Researchers:
|
Au W.Y.,
Kwong Y.L.
and Ma E.S.K.,
Acute myeloid leukemia after Dengue fever in a patient
with Hemoglobin H disease, Haematologica. 2001,
86: E17.
|
|
Au W.Y.,
Gascoyne R.D., Connors J.M., Viswanatha D.S., Klasa
F.J. and Horsman D.E., Cytogenetic evolutio nin mantle
cell lymphoma, Leukemia and Lymphoma. 2002,
43: 783-791.
|
|
Au W.Y.,
Ma E.S.K. and
Kwong Y.L.,
Disseminated hepatosplenic mycobacterial infection
masking myeloproliferative diseases as leukemoid reaction:
a diagnostic pitfall, Leukemia and Lymphoma.
2001, 42(4): 805-808.
|
|
Au W.Y.,
Luo X., Liang R.H.S.
and Lau G.,
Hepatitis B virus reactivation after cytotoxic or immunosuppresive
therapy, pathogenesis and management, Rev Med Virol.
2001, 5: 287-299.
|
|
Au W.Y.,
Lie A.K.W.,
Hon C., Yeung C.K., Chan
H.H.L. and Ma S.Y., Keratodrema blenorrhagica,
balanitis and uveitis after HLA-B15 mismatched bone
marrow transplantation, Haematologica. 2002,
ERC13.
|
|
Au W.Y.,
Kwong Y.L.
and Ma E.S.K.,
Myeloproliferatie disease masquerading as leukemoidreaction
secondary to disseminated mycobacterial infection,
Leukemia and Lymphoma. 2001, 42: 805-808.
|
|
Au W.Y.,
Lie A.K.W.,
Kwong Y.L.,
Shek T.W.H.,
Hawkins B.R.,
Lai K.N., Tang S.C.W., Lo C.M., Fan
S.T., Liu C.L.,
Chan G.C.F.,
Chau M.C.,
Chiu S.W. and
Liang R.H.S.,
Post-transplantation lymphoproliferative disease in
Chinese: the Queen Mary Hospital experience in Hong
Kong, Leukemia and Lymphoma. 2002, 43: 1405-14September .
|
|
Au W.Y.,
Lie A.K.W.,
Liang R.H.S.,
Chan G.C.F.
and Kwong Y.L.,
Sustained and Repeated Response of Relapsed Acute Promyelocytic
Leukaemia to Intravenous or Oral Arsenic Trioxide,
7th Medical Research Conference, Hong Kong, 26-27
January 2002. 24(2): 46.
|
|
Au W.Y.,
Horsman D.E., Ohno H., Klasa F.J. and Gascoyne R.D.,
Translocation (14;19)(q32;q13) in CLL/SLL, Leukemia
and Lymphoma. 2002, 43: 813-816.
|
|
Lau G., Leung A.Y.H.,
Au W.Y.,
Kwong Y.L.,
Lie A.K.W.,
Liang R.H.S.,
Hou J., Nanji A.A.
and Fong D.Y.T.,
High HBV DNA viral load is the most significant risk
factor for hepatitis B reactiation in hepatitis B surface
antign positive patients treated with autologous hematopoietic
stem cell transplantation, Blood.
2002, 99: 2324-2330.
|
|
Lau G., Au W.Y., Lie A.K.W., Fong
D.Y.T., Kwong Y.L.
and Liang R.H.S.,
Reduction of hepatitis due to HBV reactivation in HbsAg
positive patients undergoing allogeneic bone marrow
transplantation with pre-emptive lamuvidine treatment.,
52th Annual Meeting of American Association for
study of Liver disease.. 2001.
|
|
Lau G.K.K.,
Leung A.Y.H.,
Fong D.Y.T.,
Au W.Y.,
Kwong Y.L.,
Lie A.K.W.,
Hou J.L., Wen Y.M., Nanji
A.A. and Liang
R.H.S., High hepatitis B virus (HBV) DNA viral
load as the most important risk factor for HBV reactivation
in patients positive for HBV surface antigen undergoing
autologous hematopoietic cell transplantation, Blood.
2002, 99: 2324-2330.
|
|
Ma E.S.K.,
Chan L.C.,
Ha S.Y., Chan G.C.F., Chan
A.Y. and Au
W.Y., The (--SEA) alpha- thalassemia deletion
ameliorates the clinical phenotype of beta Zero/beta
plus thalassaemia but no necessarily beta zero/beta
zero thalassaemia, Haematologica. 2002, 87:
4333-444.
|
|
Hu H.C., Wong Y.H., Lai K.C., Hui
W.M., Lam K.F.,
Wong B.C.Y.,
Xia H.H.X.,
Chan C.K.,
Wong W.M.,
Tsang K.W.T.
and Lam S.K.,
Normal 24-hour ambulatory proximal and distal gastroesophageal
reflux parameters in Chinese, Hong Kong Medical
Journal. Hong Kong, Hong Kong Academy of Medicine
and the Medical Association, 2002, 8: 168-171.
|
|
Wong W.M.,
Wong B.C.Y.,
Xia H.H.X.,
Tang V.S., Lai
K.C., Hu H.C.,
Yuen M.F.,
Chan C.K.
and Lam S.K.,
An evaluation of a rapid urine test for the diagnosis
of Helicobacter pylori infection in the Chinese population,
Alimentary
Pharmacology and Therapeutics. 2002, 16(4):
813-817.
|
|
Wong W.M.,
Wong B.C.Y.,
Tang V.S.Y., Wong K.W., Li T.M., Cheung K.L., Fung
F.M.Y., Lai
K.C., Hu H.C.,
Chan C.K.,
Xia H.H.X.
and Lam S.K.,
Evaluation of three near patient tests for the diagnosis
of Helicobacter pylori infectino in Chinese population,
The
Hong Kong Practitioner. 2002, 24 (2 suppl):
43.
|
|
Xia H.H.X.,
Wong B.C.Y.,
Wong K.W., Wong S.Y., Wong
W.M., Lai K.C.,
Hu H.C., Chan C.K.
and Lam S.K.,
Clinical and endoscopic characteristics of non-Helicobacter
pylori, non-NSAID duodenal ulcers: a long-term prospective
study, Alimentary
Pharmacology and Therapeutics. 2001, 15(12):
1875-1882.
|
|
Xia H.H.X.,
Wong B.C.Y.,
Wong W.M.,
Tang V.S., Cheung H.K., Sham F.N., Fung
F.M.Y., Lai
K.C., Hu H.C.,
Chan C.K.
and Lam S.K.,
Optimal serological tests for the detection of Helicobacter
pylori infection in the Chinese population, Alimentary
Pharmacology and Therapeutics. 2002, 16(3):
521-526.
|
| Project Title: | Binding of anti-DNA
immunoglobulins from patients wth lupus nephritis to
human proximal renal tubular epithelial cells (HPTC)
and their effects on HPTC expression of RANTES, MCP-1,
TGF-Beta1, and C3 |
| Investigator(s): | Prof.
Chan D.T.M., Dr. Tang S.C.W., Dr. Yung S.S.Y. |
| Department: | Medicine |
| Source(s) of Funding: | Hong
Kong Research Grants Council Competitive Earmarked
Research Grants |
| Start Date: | September 1999 |
| Abstract: |
| To determine the mechanisms of interaction
between anti-DNA antibodies and human proximal renal
tubular epithelial cells; to determine the effects
of anti-DNA antibodies on human proximal renal tubular
epithelial cell expression of pro-inflammatory and
pro-fibrotic cytokines and growth factors, namely RANTES,
MCP-1, TGF-beta1, and C3. |
| Project Title: | Modulation of human
mesangial cell hyaluronan synthesis and degradation
by anti-DNA antibodies in SLE |
| Investigator(s): | Prof.
Chan D.T.M., Dr. Yung S.S.Y. |
| Department: | Medicine |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | November 2000 |
| Abstract: |
| To isolate anti-DNA antibodies from patients
during both inactive and active SLE; to examine the
effects of anti-DNA antibodies on HMC HA synthesis
and degradation; to investigate the role of HA and
its fragments in pro-inflammatory cytokine stimulation
and cell proliferation. |
|
Chan D.T.M.,
Management of lupus nephritis. [Invited lecture given
at the Hong Kong Medical Forum, July 7-8, 2001, Hong
Kong Convention and Exhibition Centre], 2001.
|
|
Chan D.T.M.,
Management of viral hepatitis after kidney transplantation.
[Invited lecture given at the 7th Congress of the
Asian Society of Transplantation, March 2-6, 2002,
New Delhi, India], 2002.
|
|
Chan D.T.M.,
Leung J.K.H.,
Lai K.N. and
Yung S.S.Y.,
Mechanisms of interaction between anti-DNA antibodies
and human mesangial cells in systemic lupus erythematosus
[presented at the 33rd Annual Meeting of the American
Society of Nephrology], Journal of American Society
of Nephrology. October 11-16, Toronto, Canada,
2001, 11: A2492.
|
|
Chan D.T.M.,
Organ transplantation in Hong Kong. [Invited lecture
given at the International Conference on Transplantation,
July 22-27, 2001, Nagoya, Japan], 2001.
|
|
Chan D.T.M.,
Wong R.W.S.,
Lau W.C.S.,
Tsang E.W.K., Ji Y.L., Mok M.Y., Tong M.K.L., Wong
A.K.M. and Lai K.N.,
Prolonged follow-up of patients with diffuse proliferative
lupus nephritis (DPLN) treated with prednisolone and
mycophenolate mofetil (MMF). [Abstract presented at
the Annual Meting of the American Society of Nephrology,
Oct 10-17, 2001, San Francisco, USA], Journal of
the American Society of Nephrolgoy. 2001, 12: 195A.
|
|
Choy C.B.Y.,
Lo W.K., Chan D.T.M.,
Lui S.L., Tang S.C.W., Lam
M.F., Li F.K.
and Lai K.N.,
A randomised prospective comparison of intermittent
versus continuous dosing regimens of intraperitoneal
cefozolin and tobramycin in the treatment of CAPD preitonitis.
[Abstract presented at the Annual Meeting of the American
Society Nephrology, Oct 10-17, 2001, San Francisco,
USA], Journal of the American Society of Nephrology.
2001, 12: 425A.
|
|
Choy C.B.Y.,
Chan D.T.M.,
Li F.K., Lui S.L., Lo
W.K. and Lai
K.N., Long-term outcome of renal transplant in
patients with hepatitis B or C. [Abstract presented
at the European Dialysis and Transplantation Association
XXXIX Congress, July 14-17, 2002, Copenhagen, Denmark],
Nephrology Dialysis Transplantation. 2002, 17(Suppl
7): 314.
|
|
Leung J.C.K.,
Lan H.Y., Tang C.S.O., Chan D.T.M.
and Lai K.N.,
Polymeric IgA up-regulates macrophage migration inhibitory
factor (MIF) in human mesangial cell. [Abstract presented
at the Annual Meeting of the American Society of Nephrology,
Oct 10-17, 2001, San Francisco, USA], Journal of
the American Society of Nephrology. 2001, 12: 112A-113A.
|
|
Lo W.K., Cheng I.K.P.,
Ho Y.W., Choi K.S., Chan
D.T.M., Wong K.S. and Yu A.W.Y., Effect of
Kt/V on nutritional status and morbidity in CAPD patients
- a prospective randomized study. [Abstract presented
at the Annual Meeting of the American Society of Nephrology,
Oct 10-17, 2001, San Francisco, USA], Journal of
the American Society of Nephrology. 2001, 12: 452A-453A.
|
|
Lo W.K., Tong
K.L., Li C.S.,
Chan D.T.M.,
Wong A.K.M., Ho Y.W., Cheung K.O., Kwan T.H., Wong
K.S., Ng F.S.K.
and Cheng I.K.P.,
Relationship between adequacy of dialysis and nutritional
status and their impact on patient survival in CAPD
in Hong Kong, In: , Peritoneal
Dialysis International. 2001, 21(5): 441-447.
|
|
Lui S. .L., Tsang R., Wong D., Chan K. .W., Chan
D.T.M., Fung
P.C.W. and Lai
K.N., Effect of mycophenolate mofetil on severity
of nephritis and nitric oxide production in lupus-prone
MRL/Ipr mice, Lupus. 2002, 11: 411-418.
|
|
Tang S.C.W.,
Leung J.C.K.,
Lam C.W., Lam
M.F., Chan D.T.M.
and Lai K.N.,
In vitro studies of aquaporins 1 and 3 expression in
cultured human proximal tubular cells: upregulation
by transferrin but not albumin, American Journal
of Kidney Diseases. 2001, 38(2): 317-330.
|
|
Tang S.C.W.,
Leung J.C.K.,
Chan K.W., Chan Y.Y., Chan D.T.M.
and Lai K.N.,
Induction of interleukin-8 in human proximal tubule
cells: an in vitro and in vivo study. [Abstract presented
at the Annual Meeting of the American Society of Nephrology,
Oct 10-17, 2001, San Francisco, USA], Journal of
the American Society of Nephrology. 2001, 12: 664A-665A.
|
|
Tang S.C.W.,
Kwok T.K., Ho P.L.,
Tang W.M., Chan
D.T.M. and Lai
K.N., Necrotizing fasciitis in a renal transplant
recipient treated with FK 506: the first reported case,
Clinical Nephrology. 2001, 56(6): 481-485.
|
|
Tang S.C.W.,
Chan D.T.M.,
Li F.K., Choy C.B.Y., Tang
A., Ho Y.W. and Lai
K.N., Spousal renal donor transplantation in Chinese:
a ten-year experience from two regional hospitals in
Hong Kong. [Abstract presented at the European Dialysis
and Transplantation Association XXXIX Congress, July
14-17, 2002, Copenhagen, Denmark], Nephrology Dialysis
Transplantation. 2002, 17(Suppl 7): 320.
|
|
Yung S.S.Y.,
Liu Z.H., Li L.S., Lai
K.N. and Chan
D.T.M., Emodin ameliorates excessive fibronectin
synthesis by human peritoneal mesothelial cells (HPMC).
[Abstract presented at the Annual Meeting of the American
Society of Nephrology, Oct 10-17, 2001, San Francisco,
USA], Journal of the American Society of Nephrology.
2001, 12: 722A.
|
| Project Title: | Laser therapy of hypertrophic
scar |
| Investigator(s): | Dr.
Chan H.H.L., Dr. Chan E.S.Y., Dr. Lau J.W.Y. |
| Department: | Medicine |
| Source(s) of Funding: | Hong
Kong Research Grants Council Competitive Earmarked
Research Grants |
| Start Date: | December 1999 |
| Abstract: |
| To assess the role of pulsed dye laser therapy
in: a) treatment of chronic hypertrophic burn scars
among Asian patients; b) prevent the formation of hypertrophic
burn scar among Asian patients. |
| Project Title: | An in vitro model
to look at the effect of sub-lethal lasers damage on
human melanocytic expression of p16ink-4a |
| Investigator(s): | Dr.
Chan H.H.L., Prof. Lai K.N., Mr. Leung J.C.K. |
| Department: | Medicine |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | September 2000 |
| Abstract: |
| To assess the sub-lethal effect of Q-switched
Alexandrite and Q-switched Nd:YAG (1064nm) laser in
p16 expression of normal melanocytic and melanoma cell
lines. |
| Project Title: | The role of epidermal
cooling in improving the outcome of laser therapy in
the treatment of Nevus of Ota |
| Investigator(s): | Dr.
Chan H.H.L., Dr. Lam L.K. |
| Department: | Medicine |
| Source(s) of Funding: | Hong
Kong Research Grants Council Competitive Earmarked
Research Grants |
| Start Date: | December 2000 |
| Abstract: |
| To assess whether epidermal cooling would reduce
pain, swelling, complications but improve clinical
response and reduce the number of session required
for laser treatment for Nevus of Ota. |
| Project Title: | The use of vascular
lasers in the treatment of port wine stain in chinese |
| Investigator(s): | Dr.
Chan H.H.L., Prof. Wei W.I. |
| Department: | Medicine |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | November 2001 |
| Abstract: |
| To establish the importance of epidermal cooling
when 585nm pulse dye laser is used for the treatment
of port wine stain in Chinese; to compare the clinical
efficacy, patients' tolerability and complications
of two commerical available vascular lasers that are
equipped with different cooling devices in the treatment
of port wine stain in Chinese. |
|
Au W.Y., Hon C., Lie A.K., Yeung C.K., Ma S.Y. and
Chan H.H.L.,
Keratoderma blenorrhagica, balanitis and uveitis after
HLA-B15 mismatched bone marrow transplantation, Haematologica.
2002, 87(3): ECR10.
|
|
Au W.Y., Lie A.K.W., Hon
C., Yeung C.K., Chan
H.H.L. and Ma S.Y., Keratodrema blenorrhagica,
balanitis and uveitis after HLA-B15 mismatched bone
marrow transplantation, Haematologica. 2002,
ERC13.
|
|
Au W.Y., Ng W.M., Yeung C.K., Chan
H.H.L. and Jones B.M., Recurrent pyoderma gangrenosum
and myelodysplasia, Haematologica. 2001, 86:
E32.
|
|
Chan H.H.L.,
Yu F.W., Pei A. and Ma K.F., A study looking at the
role of food causing early and delayed aggravation
of atopic dermatitis in Chinese children, Annales
De Dermatologie et De Venereologie. 2002, 129:
1(2):1S408.
|
|
Chan H.H.L.,
Ying S.Y., Ho W.S., Wong
S.Y. and Lam
L.K., An in vivo study comparing the efficacy and
complications of Diode laser and long-pulsed Neodymium:
Yttrium-Aluminum-Garnet (Nd-YAG) laser in hair removal
among Chinese patients, Dermatologic
Surgery. 2001, 27: 950-4.
|
|
Chan H.H.L.,
Common dermatological problems in childhood, The
Hong Kong Paediatric Society. 22 November. 2001.
|
|
Chan H.H.L.,
Cutaneous laser surgery in Asians, 60th American
Academy of Dermatology Annual Meeting, New Orleans,
USA. 22-27 February. 2002.
|
|
Chan H.H.L.,
Cutaneous manifestation of rheumatic disease, Hong
Kong Society of Rheumatology Annual Scientific Meeting,
Marriot Hotel, Hong Kong. 23 September. 2001.
|
|
Chan H.H.L.,
Lam L.K., Wong S.Y. and
Wei W.I., Epidermal
cooling in improving the patient tolerability of Q-switched
laser for the treatment of nevus of Ota, Annales
De Dermatologie et De Venereologie. 2002, 129:
1(1):1S155-6.
|
|
Chan H.H.L.,
Itchy rash, Hong Kong Institute of Allergy Annual
General Meeting.. 2001.
|
|
Chan H.H.L.,
Non-ablative skin rejuvenation in Ethnic skin, Workshop
on non-ablative light and rejuvenation. 22rd Amercian
Society for Laser Medicine and Surgery Annual Meeting.
Atlanta, USA. 10-14 April. 2002.
|
|
Chan H.H.L.,
Tattoo and dermal pigment: what is new, Controversies
and conversations in cutaneous laser surgery. Ojai,
California, USA. 9-11 August. 2002.
|
|
Chan H.H.L.,
Lam L.K., Wong S.Y., Wei W.I. and Ho
W.S., The role of pulsed dye laser in the treatment
and prevention of hypertrophic scar, Annales De
Dermatologie et De Venereologie. 2002, 129: 1(1):1S155.
|
|
Chan H.H.L.,
The use of laser in the treatment of pigmented lesion
in children, Proceeding of the 4th Regional Scientific
Meeting on Pediatric Dermatology. Bangkok, Thailand.
8-10 November. 2001, 61.
|
|
Chuh A.A. and Chan
H.H.L., Prospective case-control study of atypical
bacterial infections in patients with pityriasis rosea,
European Journal of Dermatology. 2002, 12(2):
170-3.
|
|
Kono T., Nozaki M., Chan
H.H.L. and Mikashima Y., A retrospective study
looking at the long-term complication of Q-switched
ruby laser in the treatment of nevus of Ota, Lasers
in Surgery and Medicine. 2001, 29: 156-159.
|
|
Tsang K.W.T.,
Chan S., Leung R , Tan
K.C.B., Chan
H.H.L., Ho
J.C.S., Yan C., Ooi
C.G.C., Fung P.C. and Lam
W.K., Anti-inflammatory treatment increased exhaled
nitric oxide production on patients with active bronchiectasis.,
The Hong Kong Practitioner. 2002, 24(2): 59.
|
|
Tsang K.W.T.,
Leung J.C., Tipoe
G.L., Leung R., Yan C., Ooi
C.G.C., Chan
H.H.L., Fung
P.C.W., Lam
W.K. and Lai
K.N., Aquaporin 3 expression in respiratory mucosa
is down-regulated in bronchiectasis in vivo., The
Hong Kong Practitioner. 2002, 24(2): 58.
|
|
Tsang K.W.T.,
Leung J.C., Tipoe
G.L., Leung R., Yan C., Ooi
C.G.C., Chan
H.H.L., Fung
P.C.W., Lam
W.K. and Lai
K.N., Aquaporin 3 expression in respiratory mucosa
is down-regulated in bronchiectasis in vivo, The
Hong Kong Practitioner. 2002, 24: C-RC-8.
|
|
Wong G.W., Hui D.S., Tam C.M., Chan
H.H.L., Fok T.F., Chan Yeung M. and Lai C.K.,
Asthma, atopy and tuberculin responses in Chinese school
children in Hong Kong, Throax.
2001, 56: 770-773.
|
|
Xiang L., Chan
H.H.L., Leung C.K. and Lai
K.N., The effect of sub-lethal QS755nm lasers on
the expression of p16INK4a, Annales De Dermatologie
et De Venereologie. 2002, 129: 1(2):1S616.
|
|
Yeung C., Teo L., Xiang L. and Chan
H.H.L., A community-based epidemiological study
of acne vulgaris in Hong Kong adolescents, Annales
De Dermatologie et De Venereologie. 2002, 129:
1(2):1S386.
|
|
Yeung C.K., Teo L.H., Xiang L.H. and Chan
H.H.L., A community-based epidemiological study
of acne vulgaris in Hong Kong adolescents, In:
,
Acta Dermato-Venereologica. 2002, 82(2): 104-7.
|
|
Yu F.W., Pei A., Ma K.F. and Chan
H.H.L., A study looking at the role of food
causing early and delayed aggravation of atopic dermatitis
in Chinese children, The
Hong Kong Practitioner. 2002, 24: C-D-2.
|
| Project Title: | Application of the
APACHE II and III prognostic scoring methods in the
14-bed Intensive Care Unit at Queen Mary Hospital |
| Investigator(s): | Dr.
Chan J.C.K., Prof. Lam W.K. |
| Department: | Medicine |
| Source(s) of Funding: | Health
Services Research Fund |
| Start Date: | July 1995 |
| Abstract: |
| To evaluate the usefulness of the APACHE II
and III prognostic scoring methods in the 14-bed ICU
at Queen Mary Hospital; to compare our ICU performance
in terms of actual mortality with the predicted mortality
based on the APACHE II predictive equation; to correlate
the APACHE II and III severity scores. As the mortality
prediction equation for APACHE III is only commercially
available, a close correlation between APACHE II and
III scores would support using the APACHE II scoring
and prediction method as the standard method rather
than financially investing in the APACHE III system. |
| Project Title: | Application of the
APACHE II and III prognostic scoring methods in the
14-bed Intensive Care Unit at Queen Mary Hospital |
| Investigator(s): | Dr.
Chan J.C.K., Prof. Lam W.K. |
| Department: | Medicine |
| Source(s) of Funding: | Queen
Mary Hospital Charitable Trust Training and Research
Assistance Scheme |
| Start Date: | July 1995 |
| Abstract: |
| To evaluate the usefulness of the APACHE II
and III prognostic scoring methods in the 14-bed ICU
at Queen Mary Hospital; to compare our ICU performance
in terms of actual mortality with the predicted mortality
based on the APACHE II predictive equation; to correlate
the APACHE II and III severity scores. As the mortality
prediction equation for APACHE III is only commercially
available, a close correlation between APACHE II and
III scores would support using the APACHE II scoring
and prediction method as the standard method rather
than financially investing in the APACHE III system. |
|
Chan L.Y.,
Fong D., Lam C.L., Chan
M.M.W., Say J.T.K., Leung
Y.H., Zheng L., Ooi
C.G.C., Ip
M.S.M., Lam
W.K. and Tsang
K.W.T., Validation of the Hong Kong Chinese version
of St Georges' Respiratory Questionnaire, The Hong
Kong Practitioner. 2002, 23 Suppl 2: 30.
|
|
Lam C.L., Lam W.K.,
Ip T.Y., Ooi C.G.C., Lam
B., Ip S., Wang J., Ho J.C.M., Yan C., Chan
L.Y., Zheng L., Man
R.Y.K. and Tsang
K.W.T., Effects of herbal preparation, coriolus
versicolor Yun-Zhi, on non-small cell lung cancer (NSCLC),
Medical Research Conference, University Department
of Medicine, Hong Kong. 2001.
|
|
Lam C.L., Lam W.K.,
Yip T.C., Ooi C.G.C.,
Lam B., Ip S., Wang J., Ho J.C.M., Yan
C.P.K., Chan
L.Y., Zheng L., Man
R.Y.K. and Tsang
K.W.T., Effects of herbal preparation, corioulus
versicolor Yun-zhi, on non-small cell lung cancer (NSCLC),
Medical Research Conference, University Department
of Medicine, Hong Kong, 2001. The Hong Kong Practitioner.
2001, 23 (supp 2): 28 (G-RM-8).
|
|
Tsang K.W.T.,
Lam C.L., Ho J.C.M., Lam B., Chan
L.Y., Man
R.Y.K., Sham
J.S.T. and Lam
W.K., Coriolus versicolor Yun-Zhi could delay deterioration
of patients with advanced non-small cell lung cancer,
The Hong Kong Practitioner. 2002, 24(2) Suppl:
59.
|
| Project Title: | Transmission of tuberculosis
in Hong Kong using both molecular and conventional
epidemiological methods |
| Investigator(s): | Prof.
Chan M.M.W., Dr. Kam K.M., Dr. Tam C.M. |
| Department: | Medicine |
| Source(s) of Funding: | Hong
Kong Research Grants Council Competitive Earmarked
Research Grants |
| Start Date: | September 2000 |
| Abstract: |
| To conduct a molecular and conventional epidemiological
study on all bacteriologically proven active cases
of tuberculosis in Hong Kong Island over a period of
24 consecutive months. |
| Project Title: | Genetic and dietary
factors in the pathogenesis of chronic obstructive
pulmonary disease (COPD)-pilot study |
| Investigator(s): | Prof.
Chan M.M.W., Prof. Ip M.S.M., Dr. Tan-Un K.C. |
| Department: | Medicine |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | February 2001 |
| Abstract: |
| To determine the prevalence of glutathione
S-transferase (enzymes important for anti-oxidation)
GSTT1, GSTM1, and GSTP1 polymorphisms in patients with
COPD and controls. |
| Project Title: | Candidate gene polymorphisms
associated with asthma and allergy in Hong Kong |
| Investigator(s): | Prof.
Chan M.M.W., Prof. Ip M.S.M., Dr. Tan-Un K.C. |
| Department: | Medicine |
| Source(s) of Funding: | Hong
Kong Research Grants Council Competitive Earmarked
Research Grants |
| Start Date: | September /2001 |
| Abstract: |
| To recruit 150 Chinese patients with asthmas
from the Asthma Clinic at the Queen Mary Hospital in
Hong Kong; to phenotype these patients according to
their asthma severity and atopic status; to determine
the prevalence of some of the specific polymorphisms
of genes associated with allergy and asthma; to recruit
an equal number of controls without asthma and to determine
the prevalence of specific polymorphisms of genes associated
with allergy and asthma. |
| Project Title: | A surveillance program
of tuberculosis in old age homes in Hong Kong |
| Investigator(s): | Prof.
Chan M.M.W., Dr. Chu L.W., Dr. Dai D., Dr. Kam K.M.,
Prof. Lam W.K., Dr. Wong C.P. |
| Department: | Medicine |
| Source(s) of Funding: | S.K.
Yee Medical Foundation Grant |
| Start Date: | November 2001 |
| Abstract: |
| To conduct a cross-sectional screening examination
for tuberculosis in old age homes in several districts
in Hong Kong, SAR; to ensure that directly observed
therapy (DOT) is given to those with active disease
diagnosed through the screening program in collaboration
with the Hong Kong Government Tuberculosis and Chest
Service (Chest Service); to provide a screening examination
for tuberculosis for new residents on entry to the
old age homes participating in the program; to participate,
in collaboration with the Chest Service, in contact
examination on residents in the same home from which
an active case of tuberculosis is being diagnosed;
to provide education to the staff of old age homes
on early recognition of tuberculosis, its treatment
and possible side effects to evaluate the effectiveness
of the program. |
|
Aitkhaled N., Enarson D., Behbehani N., Chan
M.M.W. and Irisen E., The Asthma Workshop,
International Union Against Tuberculosis and Lung
Disease. 2001, 5: 973-977.
|
|
Chan L.Y.,
Fong D., Lam C.L., Chan
M.M.W., Say J.T.K., Leung
Y.H., Zheng L., Ooi
C.G.C., Ip
M.S.M., Lam
W.K. and Tsang
K.W.T., Validation of the Hong Kong Chinese version
of St Georges' Respiratory Questionnaire, The Hong
Kong Practitioner. 2002, 23 Suppl 2: 30.
|
|
Chan M.M.W.
and Loh C.C., Air pollution and health on website Civic-exchange,
Website Civic-exchange. 2002.
|
|
Chan M.M.W.,
Chairperson, Respiratory Disease Section, The International
Union Against Tuberculosis and Lung Disease. 2001.
|
|
Chan M.M.W.,
Co-supervisor of Dr. Julie Wang for her MSc thesis
in the McGill University "Transmission of tuberculosis
in the elderly in Hong Kong", 2001.
|
|
Chan M.M.W.,
Health effects of ETS in restaurants, Newsletter.
Hong Kong Thoracic Society and ACCP (HK and Macau
Chapter). 2001, 11: 11-14.
|
|
Chan M.M.W.,
Indoor allergens, In: Fitzgerald M, Ernst P, Boulet
LP O'Byrne BC Dekker Inc, Hamilton, In: Evidence-based
asthma. eds. 2001, 81-86.
|
|
Chan M.M.W.,
Law B., Sheung S.Y. and Lam
C.L.K., Internal consistency, reproducibility,
responsiveness, and construct validity of the Chinese
(HK) version of the asthma quality of life questionnaire,
Quality
of Life Research. The Netherlands, 2001, 10(8):
723-730.
|
|
Chan M.M.W.,
Law B., Sheung S.Y. and Lam C.S.L., Internal reliability,
reproducibility, construct validity of a Chinese questionnaire
on auality of life in patients with asthma, Quality
of Life Research. 2001, 10: 723-730.
|
|
Chan M.M.W.,
Member, Editorial Board, Chest (The official publication
of the American College of Chest Physicians). 2001.
|
|
Chan M.M.W.
and Malo J.L., Occupational asthma, UpToDate in
Pulmonary and Critical Care Medicine. American Thoracici
Society (revised version) CD-Rom publication. 2001.
|
|
Chan M.M.W.,
Boulet L.P. and Malo J.L., Pathophysiology of occupational
asthma, UpToDate in Pulmonary and Critical Care
Medicine in 2001 (revised version) CD-Rom publication.
2001.
|
|
Chan M.M.W.,
Respiratory Physiology and Lung function testing, Newsletter.
Hong Kong Thoracic society and ACCP (HK and Macau
Chapter). 2001, 11: 3-5.
|
|
Chan M.M.W.,
Respiratory health effects of exposure to ETS, In:
, Newsletter. Hong Kong Thoracic Society and
ACCP (HK and Macau Chapter). 2001, 11: 15-23.
|
|
Chan M.M.W.,
Noertjojo K., Chan S.L. and Tam C.M., Sex differences
in tuberculosis in Hong Kong, International Journal
of Tuberculosis and Lung Diseases. 2002, 6: 11-18.
|
|
Chan M.M.W.,
Zhang L.X., Li B., He G.X., Niniemen M. and Enarson
D., The prevalence of asthma and asthma-like symptoms
among adults in rural China, European Respiratory
Journal. 2002, 19: 853-8.
|
|
Chan M.M.W.,
Tuberculosis coltrol in Hong Kong. Are we doing enough?,
Synapse. Hong Kong College of Physicians. 2001.
|
|
Chan M.M.W.,
Noertjojo K., Chan S.L., Tan J. and Tam C.M., Tuberulosis
in the elderly in Hong Kong, international Journal
of Tuberculosis and Lung Disease. 2002.
|
|
Ho J.C.M., Hu H.C.,
Lam W.K., Chu L.W., Zheng
L., Tipoe G.L.,
Ooi C.G.C.,
Sun J.Z., Leung Y.H., Ip M.S.M., Chan M.M.W.
and Tsang K.W.T.,
The effect of aging on nasal mucociliary clearance,
beat frequency and ultrastructure of respiratory cilia,
Medical Research Conference, University Department
of Medicine, Hong Kong, 2001. The Hong Kong Practitioner.
2001, 23 (suppl 2): 66 (S-RM-5).
|
|
Malo J.L. and Chan
M.M.W., Diagnosis of occupational asthma, UpToDate
in Pulmonary and Critical Care Medicine in 2001 (revised
version) CD-Rom publication. 2001.
|
|
Malo J.L., Kennedy S. and Chan
M.M.W., Occupational agents, In: Barnes PJ,
Drazen JM, Rennard S, Thomson NC, In: Ashma and
COPD: Basic mechanisms and clinical management. Eds.
2001.
|
|
Malo J.L. and Chan
M.M.W., Reactive airways dysfunctional syndrome,
UpToDate in Pulmonary and Critical Care Medicine
in 2001 (revised version) CD-Rom publication. 2001.
|
|
Noertjojo K., Tam C.M., Chan S.L., Tan J. and Chan M.M.W.,
Contact examination for tuberculosis in Hong Kong is
useful, International Journal of Tuberculosis and
Lung Diseases. 2002, 6: 19-24.
|
|
Noertjojo K., Tam C.M., Chan S.L., Tan J. and Chan M.M.W.,
Extrapulmonary tuberculosis in Hong Kong, Int J
Tuberc Lung Dis. 2002, 6: 879-87.
|
|
Noertjojo K., Tam C.M., Chan S.L. and Chan
M.M.W., The outcome of contact tracing for
tuberculosis in Hong Kong, International Journal
of Tuberculosis and Lung Diseases. 2002, 6: 19-24.
|
|
Tan-Un K.C.
and Chan M.M.W.,
co-supervision of (Winnie Kwok) MSc students. Thesis:
on candidate gene polymorphism in asthma, 2001.
|
|
Tsang K.W.T.,
Ip S.K., Leung R., Tipoe G.L., Chan S.L., Shum I.H.,
Ip M.S.M.,
Yan C., Fung P.C., Chan
M.M.W. and Lam
W.K., Enhaled nitric oxide: the effects of age,
gender and body size, Lung.
2001, 179(2): 83-91.
|
|
Tsang K.W.T.,
Lam B., Ooi C.G.C.,
Ho J.C.S.,
Chan S., Yan C., Leung R., Ip
M.S.M., Chan
M.M.W. and Lam
W.K., Inhaled fluticasone therapy reduces exacerbation
frequency and sputum production in bronchiectasis (BX).,
The Hong Kong Practitioner. 2002, 24(2): 58.
|
|
Wong G., Hui D.S.C., Tam C.M., Chan H.H., Fok T.F.,
Chan M.M.W.
and Lai C.K.W., Asthma, atopy and tuberculin responses
in Chinese school children in Hong Kong, Thorax.
2001, 56: 770-773.
|
|
Wong M., Chan S., Yan C., Chan
M.M.W., Ho
J.C.S., Lam B., Ooi
C.G.C., Ip
M.S.M., Lam
W.K. and Tsang
K.W.T., Inhaled steroid therapy is associated with
improvement in quality of life among bronchiectasis
patients., The Hong Kong Practitioner. 2002,
24(2): 60.
|
| Project Title: | Application of DNA
technology in genetic diseases and blood cancers |
| Investigator(s): | Prof.
Chan V.N.Y., Prof. Chan T.K., Dr. Chiu E.K.W., Prof.
Kwong Y.L., Prof. Liang R.H.S., Prof. Wong V.C.N. |
| Department: | Medicine |
| Source(s) of Funding: | Croucher
Foundation |
| Start Date: | September 1993 |
| Abstract: |
| Studies in the molecular biology of other neurogenetic
diseases: spinal muscular atrophy (SMA) and fragile
X syndrome; development of simpler techniques in the
diagnosis of thalassaemia and haemophilias; application
of fluorescent-in-situ hybridization to (a) prenatal
diagnosis and (b) detection of minimal disease in blood
cancers; detection of mixed chimerism after bone marrow
transplantation as early detection of engraftment and/or
relapse. |
| Project Title: | Iron overload in haemoglobin
H disease |
| Investigator(s): | Prof.
Chan V.N.Y., Dr. Chim J.C.S., Prof. Liang R.H.S. |
| Department: | Medicine |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | November 2001 |
| Abstract: |
| To identify the pathogenic mechanism accounting
for iron-overload in these patients. |
|
Chan V.N.Y.,
Expert Reviewer, Thalassaemia Foundation, Hong Kong.
2002.
|
|
Chan V.N.Y.,
Reviewer, American Journal of Hematology. 2001.
|
|
Chan V.N.Y.,
Reviewer, Archives of Medical Research. 2002.
|
|
Cheung P.T.,
Chan K.W.,
Qong Z.Q., Kwan
E.Y.W., Tam S.C.F., But B., Lam
K.S.L., Chan
V.N.Y. and Low
L.C.K., Novel Mutations of ABCG5 and ABCG8 Genes
in 15 Chinese Sitosterolaemia Patients, Endo 2002,
84th Annual Meeting, Endocrine Society, San Franciso,
USA, 19-22 June 2002. 315.
|
|
Lau K.S., Chan V.N.Y.
and Kung A.W.C.,
Genetic Mapping for thyrotoxic Periodic Paralysis,
Second International Huaxia Congress of Endocrinology,
Hong Kong, December 2001.
|
|
Xu J., Zhang
W., Chan
V.N.Y. and Lam
K.S.L., Functional Analysis of Mutations in the
Hepatocyte Nuclear Factor-1 alpha Gene in Chinese MODY
Families, Sixth Research Postgraduate Symposium,
September 26-28, 2001, The University of Hong Kong,
Hong Kong. 2001.
|
|
Xu J., Zhang
W., Chan
V.N.Y. and Lam
K.S.L., Mutations in the Hepatocyte Nuclear Factor-1
alpha Gene in Chinese MODY Families: Prevalence and
Functional Analysis., Second International Huaxia
Congress of Endocrinology, December 14-17, 2001.
Hong Kong.
|
|
Zhou X., Ha S.Y., Chan
G.C.F., Luk C.W., Chan
V.N.Y., Hawkins
B.R., Lam Y.H.,
Liang R.H.S.
and Lau Y.L.,
Successful mismatched sibling cord blood transplant
in Hb Bart's disease, Bone Marrow Transplantation.
2001, 28: 105-107.
|
|
Mok C.C., Ho C.T.K.,
Chan W.K.,
Lau W.C.S.
and Wong R.W.S.,
Outcome and prognostic indicators of diffuse proliferative
lupus glomerulonephritis (SLE-DPGN) treated with sequential
oral cyclophosphamide (CYC) and azathioprine (AZA),
Arthritis & Rheumatism. 2001, 44(9 Supple):1369:
S281.
|
|
Tong T.K., Yeung
J.S.L., Yang
D., Wu A.Y.Y.,
Chan W.K.,
Chiu P.K.Y.,
Tang W.M. and
Lau W.C.S.,
Effects of triptolide, an active ingredient of trypterygium
Wilfordii Hook F (Thunder God Vine, a traditional Chinese
herb), on rheumatoid synovial fibroblast function,
The Hong Kong Practitioner. 2001, 23(2)(Supple):
33.
|
|
Tong T.K., Yeung
J.S.L., Yang
D., Wu A.Y.Y.,
Chan W.K.,
Chiu P.K.Y.,
Tang W.M. and
Lau W.C.S.,
Effects of triptolide, an active ingredient of trypterygium
Wilfordii hook F (thunder god vine, a traditional Chinese
herb), on rheumatoid synovial fibroblast function,
Annals of the Rheumatic Diseases. 2001, 8(supple):
107.
|
|
Wu A.Y.Y.,
Chan W.K.,
Chik S.C.C.,
Ren Y. and
Lau W.C.S.,
B cells from SLE patients display accelerated apoptosis
and reduced anti-apoptotic response to sIgM and CD40
ligation, The Hong Kong Practitioner. 2001,
23(2)(Supple): 33.
|
|
Tang S.C.W.,
Leung J.C.K.,
Chan K.W., Chan Y.Y.,
Chan D.T.M.
and Lai K.N.,
Induction of interleukin-8 in human proximal tubule
cells: an in vitro and in vivo study. [Abstract presented
at the Annual Meeting of the American Society of Nephrology,
Oct 10-17, 2001, San Francisco, USA], Journal of
the American Society of Nephrology. 2001, 12: 664A-665A.
|
|
Au W.Y., Lie A.K.W., Kwong Y.L., Shek T.W.H., Hawkins B.R., Lai K.N., Tang
S.C.W., Lo
C.M., Fan S.T.,
Liu C.L., Chan G.C.F., Chau M.C.,
Chiu S.W. and
Liang R.H.S.,
Post-transplantation lymphoproliferative disease in
Chinese: the Queen Mary Hospital experience in Hong
Kong, Leukemia and Lymphoma. 2002, 43: 1405-14September .
|
|
Yu C.M., Chau M.C.,
Sanderson J.E., Fan
Y.Y., Tang
M.O., Fung W.H., Lin
H., Kong S.L.,
Lam Y.M., Hill
M.R. and Lau C.P.,
Tissue Doppler echocardiographic evidence of reverse
remodeling and improved synchronicity by simultaneously
delaying regional contraction after biventricular pacing
therapy in heart failure., In: , Circulation.
2002, 105: 438-45.
|
|
Yu C.M., Tse H.F., Chau M.C.,
Fan Y.Y., Lee K.L.F., Leung
S.K., Wan S.H. and Lau
C.P., 雙心室起搏治療心力衰竭的初步經驗, In: , 中華心律失常學雜誌, 2002,
4.
|
| Project Title: | A randomized placebo-controlled
trial to test whether abciximab can reduce in-stent
restonosis in diabetic patients after intra coronary
stenting |
| Investigator(s): | Dr.
Chen W.H., Prof. Lau C.P., Dr. Lau Y.K., Dr. Leung
W.S. |
| Department: | Medicine |
| Source(s) of Funding: | Eli
Lilly Asia Inc.
Guidant
Hong Kong Ltd. |
| Start Date: | January 2001 |
| Abstract: |
| To investigate whether abciximab can reduce
in-stent restenosis in diabetic patients after intra
coronary stenting. |
| Project Title: | A pilot study to evaluate
the safety and efficacy of reperfusion therapy using
abciximab and intravenous enoxaparin in patients older
than 75 years with acute myocardial infarction |
| Investigator(s): | Dr.
Chen W.H., Prof. Lau C.P. |
| Department: | Medicine |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | June 2001 |
| Abstract: |
| To evaluate the efficacy and safety of a reperfusion
therapy using a combination of abciximab and intravenous
enoxaparin in patients age 75 years or older with acute
myocardial infarction. |
| Project Title: | Enoxaparin combined
with eptifibatide or abciximab versus unfractionated
heparin combined with eptifibatide or abciximab in
percutaneous coronary intervention: observations on
efficacy, safety, anticoagulation profile, and level
of platelet inhibition |
| Investigator(s): | Dr.
Chen W.H., Prof. Lau C.P. |
| Department: | Medicine |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | November 2001 |
| Abstract: |
| To study efficacy, safety, anticoagulation
profile, and level of platelet inhibition of enoxaparin
combined with eptifibatide or abciximab versus unfractionated
heparin combined with eptifibatide or abciximab in
percutaneous coronary intervention. |
|
Lau C.P., Tse H.F., Ng W.,
Chan K.K., Li S.K., Keung K.K., Lau Y.K., Chen
W.H., Tang Y.W. and Leung S.K., Comparison
of perindopril versus captopril for treatment of acute
myocardial infarction., Am J Cardiol. 2002,
89: 150-154.
|
|
Wong W.M.,
Lai K.C., Lau C.P., Hu
H.C., Chen
W.H., Wong
B.C.Y., Hui
W.M., Wong
Y.H., Xia H.H.X.
and Lam S.K.,
Upper gastrointestinal evaluation of Chinese Patients
with non-cardiac chest pain, Alimentary
Pharmacology and Therapeutics. 2002, 16(3):
465-471.
|
|
Wong W.M., Lai K.C., Lau
C.P., Hu W.H., Chen
W.H., Wong B.C., Hui W.M., Wong Y.H., Xia H.H.
and Leung S.K., Upper gastrointestinal evaluation of
Chinese patients with non-cardiac chest pain., Aliment
Pharmacol Ther.. 2002, 16: 465-71.
|
|
Wong W.M.,
Lai K.C., Lau C.P., Hu
H.C., Chen
W.H., Wong
B.C.Y., Hui
W.M., Wong
Y.H., Xia H.H.X.
and Lam S.K.,
Upper gastrointestinal evaluation of Chinese patients
with noncardiac chest pain, The
Hong Kong Practitioner. 2002, 24 (2 suppl):
44.
|
|
Yu C.M., Lau C.P., Lai
K.W., Huang X.R., Chen
W.H. and Lan
H.Y., Elevation of plasma level of macrophage migration
inhibitory factor in patients with acute myocardial
infarction., Am J Cardiol. 2001, 88: 774-7.
|
|
Chen X.,
Effecrts of high glucose, peritoneal dialysis fluid
and heparin on proteoglycan synthesis in human peritoneal
mesothelial cells, Hong Kong, 2001.
|
|
Lo W.K., Cheng I.K.P.,
Ho Y.W., Choi K.S., Chan
D.T.M., Wong K.S. and Yu A.W.Y., Effect of Kt/V
on nutritional status and morbidity in CAPD patients
- a prospective randomized study. [Abstract presented
at the Annual Meeting of the American Society of Nephrology,
Oct 10-17, 2001, San Francisco, USA], Journal of
the American Society of Nephrology. 2001, 12: 452A-453A.
|
|
Lo W.K., Tong
K.L., Li C.S.,
Chan D.T.M.,
Wong A.K.M., Ho Y.W., Cheung K.O., Kwan T.H., Wong
K.S., Ng F.S.K.
and Cheng I.K.P.,
Relationship between adequacy of dialysis and nutritional
status and their impact on patient survival in CAPD
in Hong Kong, In: , Peritoneal
Dialysis International. 2001, 21(5): 441-447.
|
| Project Title: | Cost implications
of new guidelines on cholesterol reduction in patients
with coronary heart disease |
| Investigator(s): | Dr.
Cheung B.M.Y., Prof. Kumana C.R., Prof. Lau C.P. |
| Department: | Medicine |
| Source(s) of Funding: | Health
Services Research Fund |
| Start Date: | June 1996 |
| Abstract: |
| To compile a database of patients with coronary
heart disease under the care of the Division of Cardiology
of Queen Mary Hospital and identify those requiring
lipid-lowering therapy; to analyse the costs, benefits,
and cost-effectiveness of treating hypercholesterolaemia
in coronary heart disease patients using statins; to
assess the cost-effectiveness of dietary classes and
interviews. |
| Project Title: | Cost-effectiveness
of low salt diet in lowering blood pressure in Hong
Kong Chinese |
| Investigator(s): | Dr.
Cheung B.M.Y., Prof. Lau C.P., Dr. McGhee S.M., Ms
Ng P.P.Y. |
| Department: | Medicine |
| Source(s) of Funding: | Health
Services Research Fund |
| Start Date: | April 1998 |
| Abstract: |
| To investigate the relationship between blood
pressure and sodium intake in the general population;
to compare the effectiveness of dietary salt reduction
with conventional treatment in lowering blood pressure;
to compare cost of low salt diet and standard drug
therapy. |
| Project Title: | The role of adrenomedullin
in inflammatory diseases of the airways - asthma and
bronchiectasis |
| Investigator(s): | Dr.
Cheung B.M.Y., Prof. Ip M.S.M., Prof. Kumana C.R.,
Dr. Tsang K.W.T. |
| Department: | Medicine |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | July 1998 |
| Abstract: |
| To test the hypothesis that adrenomedullin
level in plasma or sputum in patients with asthma and
bronchiectasis reflects inflammatory activity in the
airways. |
| Project Title: | Angiotensin-converting
enzyme, bradykinin and endothelial function |
| Investigator(s): | Dr.
Cheung B.M.Y., Prof. Fung P.C.W., Prof. He G.W., Dr.
Tan K.C.B., Dr. Tsang K.W.T. |
| Department: | Medicine |
| Source(s) of Funding: | Hong
Kong Research Grants Council Competitive Earmarked
Research Grants |
| Start Date: | December 1999 |
| Abstract: |
| To confirm the relationship between angiotensin-converting
enzyme (ACE) genotype, ACE inhibition and bradykinin
level; to assess the relationship between bradykinin
level and endothelial function (production of nitric
oxide and flow-mediated dilatation); to assess the
influence of ACE genotype on endothelial function in
vitro and in vivo. |
| Project Title: | The role of adrenomedullin
in inflammation |
| Investigator(s): | Dr.
Cheung B.M.Y., Dr. Lan H.Y., Prof. Lau W.C.S., Prof.
Tang F., Dr. Tsang K.W.T. |
| Department: | Medicine |
| Source(s) of Funding: | Hong
Kong Research Grants Council Competitive Earmarked
Research Grants |
| Start Date: | October 2000 |
| Abstract: |
| To investigate whether human adrenomedullin
(AM) is an inflammatory or anti-inflammatory cytokine
in vitro and in vivo. For patients with systemic lupus
erythematosus (SLE), the project will study the changes
in AM level during relapses and remissions, and after
immunosuppressive therapy. The research will lead
to new strategies to treat systemic inflammatory conditions,
and pave way for the development of anti-inflammatory
and immunosuppressive agents with fewer adverse effects. |
| Project Title: | Plasma homocysteine
and cardiovascular risk in Hong Kong Chinese |
| Investigator(s): | Dr.
Cheung B.M.Y., Prof. Lau C.P., Dr. O K. |
| Department: | Medicine |
| Source(s) of Funding: | RGC
Fundable Projects (Block Grant Funded) |
| Start Date: | November 2000 |
| Abstract: |
| To set up a homocysteine (HCY) assay; to determine
a reference range for men and women; to measure HCY
in patients who have developed or are at risk from
cardiovascular disease. |
| Project Title: | Hong Kong cardiovascular
risk factor prevalence study-2 (CRISPS-2) |
| Investigator(s): | Dr.
Cheung B.M.Y., Dr. Cheng C.H., Prof. Lam K.S.L., Prof.
Lam T.H., Prof. Lau C.P., Dr. Tam S.C.F., Dr. Wat N.M.S. |
| Department: | Medicine |
| Source(s) of Funding: | Hong
Kong Research Grants Council Competitive Earmarked
Research Grants |
| Start Date: | October 2001 |
| Abstract: |
| To determine the cumulative incidence of hypertension
and diabetes, which are risk factors for cardiovascular
diseases, in the cohort of subjects recruited in the
Hong Kong Cardiovascular Risk Factor Prevalence Study
in 1995-6; to determine the incidence of cardiovascular
and non-cardiovascular diseases since the Hong Kong
Cardiovascular Risk Factor Prevalence Study in 1995-6;
to analyse the baseline factors to see if they are
predictors of hypertension and diabetes, and if so,
to quantify the risk and to study their interactions;
to measure changes in baseline risk factors, which
may have important consequences on public health. |
| Project Title: | Hypertension genes
in Hong Kong Chinese |
| Investigator(s): | Dr.
Cheung B.M.Y., Prof. Lau C.P. |
| Department: | Medicine |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | November 2001 |
| Abstract: |
| To study several new candidate genes that have
been identified in whole genome search. By targeting
specific candidate genes in our large bank of accurately
defined hypertensive patients and normal controls,
we can achieve high power in either confirming or refuting
their association with hypertension in a Chinese population. |
|
Chau J., Cheung
B.M.Y., McGhee
S.M., Lauder
I.J., Lau C.P.
and Kumana C.R.,
The CARE study applied to Hong Kong patients - a cost-benefit
analysis, 7th Scientific Meeting of the Hong Kong
Pharmacology Society in Association with the Zhejiang
Pharmacological Society, Hong Kong 2001.
|
|
Cheung B.M.Y.,
Blockade of the renin-angiotensin system, Hong Kong
Medical Journal. 2002, 8: 185-91.
|
|
Cheung B.M.Y.,
Ho G.Y.Y., Ng P.P.Y., McGhee
S.M., Kumana
C.R. and Lau
C.P., Change in ambulatory blood pressure in hypertensive
patients is related to sodium intake, 2nd Congress
of Asian-Pacific Society of Hypertension, Pattaya 2001.
|
|
Cheung B.M.Y.,
Chow V., O K.
and Lau C.P.,
Elevated plasma homocysteine is associated with ischaemic
heart disease is Hong Kong Chinese, 3rd Meeting
of the Federation of the European Pharmacological Societies,
Lyons 2001.
|
|
Cheung B.M.Y.,
Lo L.F., Lam T.H., Lam
K.S.L., Lau
C.P., Tam S.C.F.,
Wat N.M.S.,
Man Y.B. and
Cheng C.H., Follow up of the Hong Kong cardiovascular
risk factor prevalence survey cohort, J HK Coll
Cardiol. 2002, 10 (Supple): 129.
|
|
Cheung B.M.Y.,
Law C.Y., O K.,
Man R.Y.K.
and Lau C.P.,
Homocysteine Levels are Elevated in Patients with Ischaemic
Heart Disease and Hypertension in Hong Kong , The
10th Annual Scientific Congress, 21-23 June, 2002.
9.
|
|
Cheung B.M.Y.,
Law C.Y., O K.,
Man R.Y.K.
and Lau C.P.,
Increased Homocysteine Levels in Patients with Ischaemic
Heart Disease and Hypertension, The 7th Medical
Research Conference dd 26 January 2002. 26.
|
|
Cheung B.M.Y.,
Law C.Y., Tam S.C.F., Kumana C.R. and
Lau C.P., Plasma
renin and aldosterone in patients with essential hypertension,
7th Scientific Meeting of the Hong Kong Pharmacology
Society in Association with the Zhejiang Pharmacological
Society, Hong Kong 2001.
|
|
Cheung B.M.Y.,
Polymorphisms affecting cardiovascular and metabolic
disease and drug responses: hypertension, 9th International
Symposium of the Pacific Rim Association for Clinical
Pharmacogenetics, Hong Kong 2001.
|
|
Cheung B.M.Y.,
Lo L.F., Lam T.H., Lam
K.S.L., Lau
C.P., Tam S.C.F.,
Wat N.M.S.,
Man Y.B. and
Cheng C.H., Six year follow up of the Hong Kong cardiovascular
risk factor prevalence survey cohort, Cardiovascular
Drugs Therapeutics. 2002, 16(Supple 1): 26-27.
|
|
Cheung B.M.Y.,
Lam T.C., Law C.Y.,
Kumana C.R.
and Lau C.P.,
The relationship between blood pressure and obesity
in Hong Kong Chinese, 2nd Congress of Asian-Pacific
Society of Hypertension, Pattaya 2001.
|
|
Cheung B.M.Y.,
Update on the treatment of hypertension, Journal
of Hong Kong College of Cardiology. 2002, 10(1):
17-20.
|
|
Kumana C.R.,
Cheung B.M.Y.
and Lauder I.J.,
Statins benefit Coronary Heart Disease Patients more
than Hypercholesterolaemic Subjects: Inferences Based
on NNT, 11th international Congress on Cardiovascular
Pharmacotherapy - Montreal Cardiovascular Drugs and
Therapy. 2002, 16(Suppl 1): 49-P310.
|
|
Lam T.C., Cheung
B.M.Y., Chung
S.S.M. and Lau
C.P., Age is a strong cardiovascular risk factor
in hypertensive patients, Hong Kong College of Cardiology.
2001, 9(Supple): 118.
|
|
Lam T.C., Cheung
B.M.Y., Chung
S.S.M. and Lau
C.P., Age is associated with high cardiovascular
risk in hypertensive patients, 7th Scientific Meeting
of the Hong Kong Pharmacology Society in Association
with the Zhejiang Pharmacological Society, Hong Kong
2001.
|
|
Lam T.C., Cheung
B.M.Y., Chung
S.S.M. and Lau
C.P., Age is the strongest predictor of systolic
blood pressure in hypertensive patients, 6th Research
Postgraduate Symposium of the University of Hong Kong
2001.
|
|
Lam T.C., Cheung
B.M.Y., Chung
S.S.M. and Lau
C.P., Aging is associated with high cardiovascular
risk in hypertensive patients, 9th International
Symposium of the Pacific Rim Association for Clinical
Pharmacogenetics, Hong Kong 2001.
|
|
Lam TC and Cheung
B.M.Y., Environmental factors of hypertension,
Medical Progress. 2001, 28(11): 8-12.
|
|
Li N., Kumana C.R.,
Cheung B.M.Y.,
Chau J., Liu C.L. and Fan
S.T., Liver volume dependent C3-dydroxylation of
diazepam metabolism, Journal of Clinical Pharmacology.
2001, 41: 1014-33.
|
|
Yu C.M., Cheung B.M.Y.,
Leung R., Wang Q., Lai W.H. and Lau
C.P., Increase in plasma adrenomedulin in patients
with heart failure characterised by diastolic dysfunction.,
Heart. 2001, 86(2): 155-160.
|
| Project Title: | Homocysteine and folate
in Chinese stroke patients |
| Investigator(s): | Dr.
Cheung R.T.F. |
| Department: | Medicine |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | November 2000 |
| Abstract: |
| To determine the serum level of folate and
plasma level of homocysteine among Chinese patients
with different types of stroke; to correlate the serum
level of folate and plasma level of homcysteine with
carotid artery atherosclerosis in Chinese patients
with different types of stroke. |
| Project Title: | Further studies on
neuroprotection of melatonin against focal cerebral
ischaemia in rats |
| Investigator(s): | Dr.
Cheung R.T.F. |
| Department: | Medicine |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | November 2001 |
| Abstract: |
| To examine the neuroprotective potential of
melatonin in a rat middle cerebral artery occlusion
(MCAO) stroke model. |
|
Li G., Liu
H.L., Cheung
R.T.F., Chan Q.C.C., Hung Y.C., Chen J.C.,
Wong K.K.,
Chou A., Wai Y.Y., Shen
G.G., Ma Q.
and Yang E.S.,
An fMRI Study of Correlation between Acupoints andj
Brain Cortical Sites. Human Brain Mapping, 2002.
|
|
Wu A.Y.Y.,
Chan W.K.,
Chik S.C.C.,
Ren Y. and
Lau W.C.S.,
B cells from SLE patients display accelerated apoptosis
and reduced anti-apoptotic response to sIgM and CD40
ligation, The Hong Kong Practitioner. 2001,
23(2)(Supple): 33.
|
|
Chim J.C.S.,
Liang R.H.S.,
Wong A.S.Y.
and Kwong Y.L.,
Methylation profiling in acute leukaemia., American
Association for Cancer Research Satellite Meeting on
cancer and chromosomal organization : Epigenetics of
Cancer. San Francisco, USA.. 2001.
|
| Project Title: | Bone marrow transplantation
in Hong Kong |
| Investigator(s): | Dr.
Chiu E.K.W., Prof. Chan T.K., Prof. Liang R.H.S., Prof.
Todd D. |
| Department: | Medicine |
| Source(s) of Funding: | Blood
Cancer Research Fund
Pfizer
Asia Corporation |
| Start Date: | May 1990 |
| Abstract: |
| To study prospectively the clinical results
of bone marrow transplantation in Hong Kong Chinese
patients with haematological malignancies. |
| Project Title: | G-CSF trial |
| Investigator(s): | Dr.
Chiu E.K.W. |
| Department: | Medicine |
| Source(s) of Funding: | Roche
Pharmaceuticals and Chemicals Ltd. |
| Start Date: | January1992 |
| Abstract: |
| To study G-CSF trial. |
|
Choi C.Y.,
Free Radicals and Bone Marrow Diseases - A Potential
Role of Nitric Oxide in Graft-Versus-Host Disease After
Bone Marrow Transplant (MPhil thesis). 2001.
|
|
Leung A.Y.H.,
Suen C., Chow
C.H., Liang
R.H.S., Lie
A.K.W. and Kwong
Y.L., Quantitative and genotypic analysis of polyoma
BK viruria during hemorrhagic cystitis complicating
bone marrow transplantation., 43rd Annual Meeting
of American Society of Hematology, Orlando, USA..
2001.
|
|
Choy C.B.Y.,
Lo W.K., Chan D.T.M., Lui S.L., Tang
S.C.W., Lam M.F., Li
F.K. and Lai
K.N., A randomised prospective comparison of intermittent
versus continuous dosing regimens of intraperitoneal
cefozolin and tobramycin in the treatment of CAPD preitonitis.
[Abstract presented at the Annual Meeting of the American
Society Nephrology, Oct 10-17, 2001, San Francisco,
USA], Journal of the American Society of Nephrology.
2001, 12: 425A.
|
|
Choy C.B.Y.,
Chan D.T.M.,
Li F.K., Lui S.L., Lo
W.K. and Lai
K.N., Long-term outcome of renal transplant in
patients with hepatitis B or C. [Abstract presented
at the European Dialysis and Transplantation Association
XXXIX Congress, July 14-17, 2002, Copenhagen, Denmark],
Nephrology Dialysis Transplantation. 2002, 17(Suppl
7): 314.
|
|
Tang S.C.W.,
Chan D.T.M.,
Li F.K., Choy C.B.Y.,
Tang A., Ho Y.W. and Lai
K.N., Spousal renal donor transplantation in Chinese:
a ten-year experience from two regional hospitals in
Hong Kong. [Abstract presented at the European Dialysis
and Transplantation Association XXXIX Congress, July
14-17, 2002, Copenhagen, Denmark], Nephrology Dialysis
Transplantation. 2002, 17(Suppl 7): 320.
|
| Project Title: | Fall and fall-related
injuries in community-dwelling elderly persons in Hong
Kong - a study on risk factors, functional decline
and health services utilization after falls |
| Investigator(s): | Dr.
Chu L.W., Prof. Chi I. |
| Department: | Medicine |
| Source(s) of Funding: | Health
Services Research Fund |
| Start Date: | March 1998 |
| Abstract: |
| To investigate the risk factors associated
with repeated falls; to investigate the risk factors
associated with a single (isolated) falls; to investigate
the effect of falls in relation to functional decline,
mortality, nursing home placement and health services
utilizations: in a sample of community-dwelling elderly
population in Hong Kong. |
|
Cheng Y.H.,
Wu L.H., Chu
L.W. and Law W.J., Job satisfaction among private
elderly home workers in Hong Kong: Effects on quality
of care (Abstract), Gerontology. 2001, 47 (Suppl
1): 81-82.
|
|
Ho J.C.M., Hu H.C.,
Lam W.K., Chu L.W.,
Zheng L., Tipoe
G.L., Ooi C.G.C.,
Sun J.Z., Leung Y.H., Ip M.S.M., Chan M.M.W. and
Tsang K.W.T.,
The effect of aging on nasal mucociliary clearance,
beat frequency and ultrastructure of respiratory cilia,
Medical Research Conference, University Department
of Medicine, Hong Kong, 2001. The Hong Kong Practitioner.
2001, 23 (suppl 2): 66 (S-RM-5).
|
|
Chuh A.A.T.,
Chiu S.S.S.
and Peiris J.S.M.,
Human Herpesvirus 6 and 7 DNA in Peripheral Blood Leucocytes
and Plasma in Patients with Pityriasis Rosea by Polymerase
Chain Reaction: A Prospective Case Control Study, Acta
Dermatology and Venereology. 2001, 81: 289-290.
|
|
Chung
S.Y., The Progression of CCl4-induced
Liver Cirrhosis of Rats and the Protective Effects
of Colchicine and Green Tea Polyphenols (MPhil thesis).
2001.
|
|
Fan Y.Y.,
Lee K.L.F.,
Chow W.H., Chau E. and Lau
C.P., Internal cardioversion of chronic atrial
fibrillation during percutaneous mitral commissurotomy:
insight into reversal of chronic stretch-induced atrial
remodeling., Circulation. 2002, 105: 2746-2752.
|
|
Tse H.F., Lee K.L.F., Fan Y.Y. and
Lau C.P., Nonfluoroscopic
magnetic electroanatomic mapping to facilitate focal
pulmonary viens ablation for paroxysmal atrial fibrillation.,
Pacing Clin Electrophysiol. 2002, 25: 57-61.
|
|
Yu C.M., Chau M.C., Sanderson
J.E., Fan Y.Y.,
Tang M.O.,
Fung W.H., Lin
H., Kong S.L.,
Lam Y.M., Hill
M.R. and Lau C.P.,
Tissue Doppler echocardiographic evidence of reverse
remodeling and improved synchronicity by simultaneously
delaying regional contraction after biventricular pacing
therapy in heart failure., In: , Circulation.
2002, 105: 438-45.
|
|
Yu C.M., Tse H.F., Chau
M.C., Fan
Y.Y., Lee
K.L.F., Leung S.K., Wan S.H. and Lau
C.P., 雙心室起搏治療心力衰竭的初步經驗, In: , 中華心律失常學雜誌, 2002,
4.
|
|
Fan X.,
Arachidonic Acid Metabolism in Apoptosis of Gastric
Cancer (PhD thesis). 2001.
|
|
Fung F.M.Y.,
Wong W.M.,
Lam S.K., Yee
Y.K., Hung W.K., Yip W.C., Szeto M.L., Tong
S.M., Lai K.C.,
Hu H.C., Hui
C.K. and Wong B.C.Y.,
Rabeprazole based 3-day and 7-day triple therapy vs
7-day omeprazole based triple therapy for the treatment
of Helicobacter pylori infection, Journal
of Gastroenterology and Hepatology. 2001, 16
(9 suppl): A127.
|
|
Gu Q., Wong
W.M., Lam S.K.,
Yin Y., Wang W.H., Fung
F.M.Y., Lai
K.C., Xia H.H.X.,
Wong B.C.Y.
and Xiao S.D., One week omeprazole, furazolidone and
amoxycillin rescue therapy after failure of Helicobacter
pylori eradication with standard triple therapies,
Gastroenterology.
2002, 122 (4 suppl 1): A586.
|
|
Wong B.C.Y.,
Wang W.P., So H.L.,
Shin V.Y.,
Wong W.M.,
Fung F.M.Y.,
Liu E.S.L.,
Hui W.M., Lam S.K. and Cho C.H., Epidermal
growth factor and its receptor in chronic active gastritis
and gastroduodenal ulcer before and after Helicobacter
pylori eradication, Alimentary
Pharmacology and Therapeutics. 2001, 15(9):
1459-1465.
|
|
Wong B.C.Y.,
Wong W.M.,
Yee Y.K., Hung W.K., Yip A.W., Seto M.L., Li K.F.,
Lau P., Fung
F.M.Y., Tong
S.M., Lai K.C.,
Hu H.C., Yuen M.F., Hui
C.K. and Lam S.K.,
Rabeprazole-based 3-day and 7-day triple therapy vs
omeprazole-based 7-day triple therapy for the treatment
of Helicobacter pylori infection, Alimentary
Pharmacology and Therapeutics. 2001, 15(12):
1959-1965.
|
|
Wong W.M.,
Wong B.C.Y.,
Tang V.S.Y., Wong K.W., Li T.M., Cheung K.L., Fung F.M.Y.,
Lai K.C., Hu H.C., Chan
C.K., Xia H.H.X.
and Lam S.K.,
Evaluation of three near patient tests for the diagnosis
of Helicobacter pylori infectino in Chinese population,
The
Hong Kong Practitioner. 2002, 24 (2 suppl):
43.
|
|
Wong W.M.,
Wong B.C.Y.,
Lu H., Gu Q.,
Yin Y., Wang W.H., Fung
F.M.Y., Lai
K.C., Xia H.H.X.,
Xiao D. and Lam
S.K., One-week omeprazole, furazolidone and amoxicillin
rescue therapy after failure of Helicobacter pylori
eradication with standard triple therapies, Alimentary
Pharmacology and Therapeutics. 2002, 16(4):
793-798.
|
|
Wong W.M.,
Gu Q., Lam
S.K., Fung
F.M.Y., Lai
K.C., Xia H.H.X.,
Hu H.C. and
Wong B.C.Y.,
Randomized controlled trial of rabeprazole, levofloxacin
and rifabutin triple therapy versus rabeprazole-based
quadruple therapy as a rescue treatment for failure
of Helicobacter pylori eradication with standard tiple
therapies, Gastroenterology.
2002, 122 (4 suppl 1): A587.
|
|
Xia H.H.X.,
Wong B.C.Y.,
Wong W.M.,
Tang V.S., Cheung H.K., Sham F.N., Fung
F.M.Y., Lai
K.C., Hu H.C.,
Chan C.K. and
Lam S.K., Optimal
serological tests for the detection of Helicobacter
pylori infection in the Chinese population, Alimentary
Pharmacology and Therapeutics. 2002, 16(3):
521-526.
|
| Project Title: | Making superoxide
microsensor for in vivo and in vitro studies in biomedical
science |
| Investigator(s): | Prof.
Fung P.C.W. |
| Department: | Medicine |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | November 2000 |
| Abstract: |
| To buildup superoxide micro-sensor by making
chemically modified electrode of size down to ~10microM;
to measure superoxide generation in diseased organs
(ischemia/reperfusion, inflammatory, dysfunctional)
of animal models in vivo. |
| Project Title: | Detection of superoxide
on organs of animal models |
| Investigator(s): | Prof.
Fung P.C.W. |
| Department: | Medicine |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | November 2001 |
| Abstract: |
| To use the Relative New Spin trap EMPO, detect
the concentrations of superoxide (and hydroxyl) free
radical in organs suffered from ischemia injury using
Electron Paramagnetic Resonance Spectronscopy (EPR). |
| Project Title: | Development of a novel
natural antioxidant with strong anti-aging and protective
properties for skin |
| Investigator(s): | Prof.
Fung P.C.W., Dr. Shen J.G. |
| Department: | Medicine |
| Source(s) of Funding: | RGC
Fundable Projects (Block Grant Funded) |
| Start Date: | July 2002 |
| Abstract: |
| To develop a novel antioxidants from herbal
products which can scavenge superoxide, hydroxyl and
lipid peroxide free radicals in skin. |
|
Au W.S., Fung P.C.W.,
Kung H. and
Lin M.C., The
hypolipidemic agent, pluronic L-81, down-regulates
the gene transcription of MTP through insulin signaling
pathway, Symposium on Molecular Technology for Drug
Discovery and Synthesis, Hong Kong, July 19-20.
2001.
|
|
Chan F.H.Y.,
Qiu W., Ting
K.H., Lam F.K.,
Wong T.K.W., Chang
C. and Fung
P.C.W., From Single Trial Evoked Potential
to Single Trial Event Related Potential (ERP), Conference
on Application of Neuro-science Technology to Educational
and Social. Hong Kong, P.R. China, HK Quality Education
Fund, 2002.
|
|
Choi C.Y., Leung
A.Y.H., Fung
P.C.W., Lie
A.K.W. and Lie
A.K.W., Plasma Nitric Oxide predicts the occurrence
of moderate to severe acute graft versus host disease
in bone marrow transplant recipients, Hematologica.
2001, 86, September -14: 972-976.
|
|
Fung P.C.W.
and Lam S.K.,
Diseases, Nitric Oxide and Related Potent Therapy,
Medical Progress. 2001, 19-22.
|
|
Fung P.C.W.,
Ting K.H.,
Shen M.F., Wong T.K.W. and Chan
F.H.Y., Some New Electroencephalogram (EEG) Results
and Interpretations of Children Learning Chinese and
English in Hong Kong, Conference on Application
of Neuro-science Technology to Educational and Social
Research. Hong Kong, P.R. China, Quality Education
Fund, 2002.
|
|
Huang X.R., Chun Hui C.W., Chen Y.X., Wong
B.C.Y., Fung
P.C.W., Metz C., Cho
C.H., Hui W.M.,
Bucala R., Lam S.K.,
Lan H.Y., Chun
B. and Wong Y., Macrophage migration inhibitory factor
is an important mediator in the pathoenesis of gastric
inflammation in rats, Gastroenterology. 2001,
121(3): 619-630.
|
|
Huang X.i.a.o. .R.u., Hui C.o.n.n.i.e. .W. .C., Chen
Y.o.n.g. .X.i.o.n.g., Wong
B.C.Y., Fung
P.C.W., Metz C.h.r.i.s.t.i.n.e., Cho C.h.i.n.
.H.i.n., Hui W.a.i. .M.o., Bucala R.i.c.h.a.r.d., Lam S.K. and Lan
H.u.i. .Y., Macrophage Migration Inhibitory Factor
is an Important Mediator in the Pathogenesis of Gastric
Inflammation, Gastroenterology.
2002, 121: 619-630.
|
|
Lam S.K. and
Fung P.C.W.,
Diseases, nitric oxide and related potent therapy,
Medical Progress. 2002, 19-22.
|
|
Li H., Fung P.C.W.,
Wu H. .S. and Yu D. .F., Experimental observation of
the relationship between the Meissner effect and the
ac magnetic susceptibility, Journal of Superconductivity.
2002, 15: 195-199.
|
|
Lui S. .L., Tsang R., Wong D., Chan K. .W., Chan
D.T.M., Fung
P.C.W. and Lai
K.N., Effect of mycophenolate mofetil on severity
of nephritis and nitric oxide production in lupus-prone
MRL/Ipr mice, Lupus. 2002, 11: 411-418.
|
|
Shen M.F., Ting
K.H., Fung
P.C.W. and Chan
F.H.Y., The Linear and Nonlinear Coherent Analysis
of Non-stationary EEG Signal, Conference on Application
of Neuro-science Technology to Educational and Social
Research. Hong Kong, P.R. China, HK Quality Education
Fund, 2002.
|
|
Shum H.Y.I.,
Zheng L., Taylor G., Lam
W.K., Fung
P.C.W., Leung
Y.H., Sun J.Z.,
Tipoe G.L.
and Tsang K.W.T.,
Pseudomonas aeruginosa 1-hycroxyphenazine stimulates
iNOS expression in human respiratory mucosa, American
Journal of Respiratory and Critical Care Medicine.
2001, 163(5): A670.
|
|
Shum H.Y.I.,
Zheng L., Taylor G., Sun
J.Z., Tipoe
G.L., Ho J.C.M., Fung
P.C.W., Lam
W.K. and Tsang
K.W.T., Upregulation of iNOS expression in human
respiratory mucosa by Pseudomonas aeruginosa 1-hydroxyphenazine,
The Hong Kong Practitioner. 2001, 23(Suppl 2):
66.
|
|
Strobel G., Ford E., Worapong J., Harper J.K., Arif
A.M., Grant D.M., Fung
P.C.W. and Chau
R.M.W., Isopestacin, an Isobenzofuranone from Pestalotiopsis
Microspora Possessing Antigungal and Antioxidant Activities,
Photochemistry. 2002, 60: 179-183.
|
|
Tham C.l.e.m.e.n.t. .C.Y., Lai J.i.m.m.y. .S. .M.,
Fung P.C.W.,
Chua J.o.h.n. .K. .H., Poon A.g.n.e.s. .S. .Y. and
Lam D.e.n.n.i.s. .S. .C., Physical Effects of Re-use
and Repeated Ethylene Oxide Sterilisation on Transscleral
Cyclophotocoagulation Laser G-probes', Journal of
Glaucoma. 2002, 11(1): 21-25.
|
|
Ting K.H.,
Fung P.C.W.
and Chan F.H.Y.,
Investigating Synchrony Between Brain Regions by Cross
Wavelet Spectrum of Electroencephalogram, Analysis
of Biomedical Signals and Images -- 16th International
EURASIP Conference Biosignal 2002 Proceedings.
Brno, Czech Republic, VUTIUM Press, 2002, 171-173.
|
|
Tsang K.W.T.,
Leung J.C., Tipoe
G.L., Leung R., Yan C., Ooi
C.G.C., Chan
H.H.L., Fung
P.C.W., Lam
W.K. and Lai
K.N., Aquaporin 3 expression in respiratory mucosa
is down-regulated in bronchiectasis in vivo., The
Hong Kong Practitioner. 2002, 24(2): 58.
|
|
Tsang K.W.T.,
Leung J.C., Tipoe
G.L., Leung R., Yan C., Ooi
C.G.C., Chan
H.H.L., Fung
P.C.W., Lam
W.K. and Lai
K.N., Aquaporin 3 expression in respiratory mucosa
is down-regulated in bronchiectasis in vivo, The
Hong Kong Practitioner. 2002, 24: C-RC-8.
|
|
Tsang K.W.T.,
Ip S.K., Leung R., Tipoe
G.L., Chan S.L., Shum I.H., Ip
M.S.M., Yan C., Fung
P.C.W., Chan-Yeung M. and Lam W., Exhaled nitric
oxide: The effects of age, gender and body size, Lung.
2001, 179: 83-91.
|
|
Wong G.W.,
Kok K.H., Kwok
K.H., Fung P.C.W.,
Kung H. and
Lin M.C., Antioxidant
enzymes and ascorbic acid protects Xenopus laevis
embryos against alcohol-induced neural injury, Symposium
on Molecular Technology for Drug Discovery and Synthesis,
Hong Kong, July 19-20. 2001.
|
|
Xu W.,
Tse H.F., Chan F.H.Y., Fung P.C.W.,
Lee K.L.F.
and Lau C.P.,
New Bayesian discriminator for detection of atrial
tachyarrhythmias, Circulation
(Journal of the American Heart Association). Philadelphia,
USA, LWW, 2002, 105 (Issue 12): 1472-1479.
|
|
Yan J.i.n., Liong E.m.i.l.y. .C., Lau T.h.o.m.a.s.
.Y.H., Fung P.C.W.,
Lung K.a. .M.a.n. and Tipoe
G.L., Overexpression of BMP-2/4, -5 and BMPR-IA
was associated with Malignancy of Oral Epithelia, Oral
Oncology. 2001, 37: 225-233.
|
|
Yao J.,
Fung P.C.W.
and Chan F.H.Y.,
Predicting the 3D Structure of the Protein Human AQPO
Using Computational Tools, Proceedings of Conference
on Biomedical Engineering BME 2002. Hong Kong,
P.R. China, HKIE Biomedical Division, 22-26.
|
|
Zheng L., Shum
H.Y.I., Lam
W.K., Tipoe
G.L., Yan C.P.K.,
Ooi C.G.C.,
Ho J.C.M., Fung
P.C.W., Ip
M.S.M. and Tsang
K.W.T., Overexpression of matrix metalloproteinase-8
(MMP-8) and-9 in bronchiectatic airways in vivo, American
Journal of Respiratiry and Critical Care Medicine.
2001, 163(5): A671.
|
|
Gu Q.,
Wong W.M.,
Lam S.K., Yin
Y., Wang W.H., Fung
F.M.Y., Lai
K.C., Xia H.H.X.,
Wong B.C.Y.
and Xiao S.D., One week omeprazole, furazolidone and
amoxycillin rescue therapy after failure of Helicobacter
pylori eradication with standard triple therapies,
Gastroenterology.
2002, 122 (4 suppl 1): A586.
|
|
Wong B.C.Y.,
Gu Q.
and Lam S.M.,
Diagnosis and treatment of Helicobacter pylori infection
in Hong Kong, Helicobacter pylori infection: basic
and clinical aspects. Chinese Science and Technology
Press, 2002, 449-455.
|
|
Wong W.M.,
Wong B.C.Y.,
Lu H., Gu Q.,
Yin Y., Wang W.H., Fung
F.M.Y., Lai
K.C., Xia H.H.X.,
Xiao D. and Lam
S.K., One-week omeprazole, furazolidone and amoxicillin
rescue therapy after failure of Helicobacter pylori
eradication with standard triple therapies, Alimentary
Pharmacology and Therapeutics. 2002, 16(4):
793-798.
|
|
Wong W.M.,
Gu Q.,
Lam S.K., Fung F.M.Y., Lai K.C., Xia
H.H.X., Hu
H.C. and Wong
B.C.Y., Randomized controlled trial of rabeprazole,
levofloxacin and rifabutin triple therapy versus rabeprazole-based
quadruple therapy as a rescue treatment for failure
of Helicobacter pylori eradication with standard tiple
therapies, Gastroenterology.
2002, 122 (4 suppl 1): A587.
|
|
Mok C.C., Ho
C.T.K., Szeto M.L. and Lau
W.C.S., Effect of menopausal status on damage in
patients with systemic lupus erythematosus (SLE), Arthritis
& Rheumatism. 2001, 44(9 supple):1424: S290.
|
|
Mok C.C., Ho
C.T.K., Chan
W.K., Lau W.C.S.
and Wong R.W.S.,
Outcome and prognostic indicators of diffuse proliferative
lupus glomerulonephritis (SLE-DPGN) treated with sequential
oral cyclophosphamide (CYC) and azathioprine (AZA),
Arthritis & Rheumatism. 2001, 44(9 Supple):1369:
S281.
|
|
Mok C.C., Ho
C.T.K., Siu Y.P., Chan K.W., Kwan T.H., Lau W.C.S., Wong R.W.S. and
Au T.C., Treatment of diffuse proliferative lupus glomerulonephritis:
a comparison of two cyclophosphamide-containing regimens,
American Journal of Kidney Diseases. 2001, 28(2):
256-64.
|
|
Chen C.N.S., Ho
D.S.W., Zhang R., Wang
Y., Santoso T. and Lim Y.L., Long Diffuse Coronary
Lesions, Course book of The Paris Course on Revascularization,
Paris. 2002.
|
|
Ho D.S.W.,
Zhang R.Y., Waser M., Shen Z.J., Wang
Y. and Ouyang P., ChoICETM
PT Wire for Recanalization of Chronically Occluded
Coronary Arteries: Multiple Wires in One?, The Journal
of Invasive Cardiology. 2002.
|
|
Tsang K.W.T.,
Chan S., Leung R , Tan
K.C.B., Chan
H.H.L., Ho
J.C.S., Yan C., Ooi
C.G.C., Fung P.C. and Lam
W.K., Anti-inflammatory treatment increased exhaled
nitric oxide production on patients with active bronchiectasis.,
The Hong Kong Practitioner. 2002, 24(2): 59.
|
|
Tsang K.W.T.,
Lam B., Ooi C.G.C.,
Ho J.C.S.,
Chan S., Yan C., Leung R., Ip
M.S.M., Chan
M.M.W. and Lam
W.K., Inhaled fluticasone therapy reduces exacerbation
frequency and sputum production in bronchiectasis (BX).,
The Hong Kong Practitioner. 2002, 24(2): 58.
|
|
Wong M., Chan S., Yan C., Chan
M.M.W., Ho
J.C.S., Lam B., Ooi
C.G.C., Ip
M.S.M., Lam
W.K. and Tsang
K.W.T., Inhaled steroid therapy is associated with
improvement in quality of life among bronchiectasis
patients., The Hong Kong Practitioner. 2002,
24(2): 60.
|
| Project Title: | Estrogenic modulation
of human catecholamine-O-methyltransferase (COMT):
its relevance in Parkinson's disease (PD) |
| Investigator(s): | Dr.
Ho S.L., Dr. Feng Z.H., Dr. Ramsden D.B., Dr. Yip H.K.F. |
| Department: | Medicine |
| Source(s) of Funding: | Hong
Kong Research Grants Council Competitive Earmarked
Research Grants |
| Start Date: | September 2000 |
| Abstract: |
| Parkinson's disease (PD) is characterized by
neurodegeneration that leads to dopamine depletion.
The cause is unknown, and gender differences appeared
in PD. The present study will explore the role of
estrogen, specifically, the hypothesis that estrogen-mediated
COMT inhibition being a contributory factor to the
gender and menstrual-related differences in PD. |
|
Feng Z.H., Guan
X.Y., Ho
S.L., Sham
J.S.T. and Wong
B.C.Y., P53 status determines nuclear factor-kapa
B response in Triptolide-induced apoptosis in gastric
cancer. Poster presentation at the 92nd Annual Meeting
of the American Association of Cancer Research, Proceedings
of American Association of Cancer Research Annual Association
of Cancer Research Annual Meeting. 2001, 42: 659.
|
|
Ho T.S.,
Effects of Anaesthetic Agent, Body Weight, Duration
of Ischaemia, and Melatonin on The Rat Middle Cerebral
Artery Occlusion Stroke Model (MPhil thesis). 2001.
|
| Project Title: | A study to validate
a symptom severity questionnaire for patents with functional
dyspepsia |
| Investigator(s): | Dr.
Hu W.H.C., Dr. Lam C.L.K. |
| Department: | Medicine |
| Source(s) of Funding: | Health
Services Research Fund |
| Start Date: | October 1998 |
| Abstract: |
| To develop and validate an instrument to measure
the severity of symptoms in patients with functional
dyspepsia. |
|
Fung F.M.Y.,
Wong W.M.,
Lam S.K., Yee
Y.K., Hung W.K., Yip W.C., Szeto M.L., Tong
S.M., Lai K.C.,
Hu H.C.,
Hui C.K. and Wong
B.C.Y., Rabeprazole based 3-day and 7-day triple
therapy vs 7-day omeprazole based triple therapy for
the treatment of Helicobacter pylori infection, Journal
of Gastroenterology and Hepatology. 2001, 16
(9 suppl): A127.
|
|
Ho J.C.M., Chan K.N., Hu
H.C., Lam
W.K., Zheng L., Tipoe
G.L., Sun J.Z.,
Leung Y.H.
and Tsang K.W.T.,
The effect of aging on nasal mucociliary clearance,
beat frequency and ultrastructure of respiratory cilia,
American
Journal of Respiratory and Critical Care Medicine.
2001, 163: 983-988.
|
|
Ho J.C.M., Hu
H.C., Lam
W.K., Chu L.W.,
Zheng L., Tipoe
G.L., Ooi C.G.C.,
Sun J.Z., Leung Y.H., Ip M.S.M., Chan M.M.W. and
Tsang K.W.T.,
The effect of aging on nasal mucociliary clearance,
beat frequency and ultrastructure of respiratory cilia,
Medical Research Conference, University Department
of Medicine, Hong Kong, 2001. The Hong Kong Practitioner.
2001, 23 (suppl 2): 66 (S-RM-5).
|
|
Hu H.C.,
Wong Y.H.,
Lai K.C., Hui W.M., Lam
K.F., Wong
B.C.Y., Xia
H.H.X., Chan
C.K., Wong
W.M., Tsang
K.W.T. and Lam
S.K., Normal 24-hour ambulatory proximal and distal
gastroesophageal reflux parameters in Chinese, Hong
Kong Medical Journal. Hong Kong, Hong Kong Academy
of Medicine and the Medical Association, 2002, 8: 168-171.
|
|
Hu H.C.,
Lam K.F., Wong Y.H., Lam C.L.K., Hui W.M., Lai
K.C., Wong
B.C.Y. and Lam
S.K., The Hong Kong index of dyspepsia: A validated
symptom severity questionnaire for patients with dyspepsia,
Journal
of Gastroenterology and Hepatology. Melbourne,
Australia, Blackwell Science, 2002, 17: 545-551.
|
|
Lai K.C., Lam S.K., Chu
K.M., Wong
B.C.Y., Hui
W.M., Hu
H.C., Lau
G., Wong W.M.,
Yuen M.F.,
Chan A.O.O., Lai
C.L. and Wong
J., Lansoprazole for the prevention of recurrences
of ulcer complications from long-term low-dose aspirin
use, New
England Journal of Medicine. 2002, 346(26):
2033-2038.
|
|
Tsang K.W.T.,
Kinoshita R., Rouke N., Yuen q., Hu
H.C. and Lam
W.K., Bronchoscopy of cetaceans, Journal of
Wildlife Diseases. 2002, 38(1): 224-227.
|
|
Wong B.C.Y.,
Wong W.M.,
Yee Y.K., Hung W.K., Yip A.W., Seto M.L., Li K.F.,
Lau P., Fung F.M.Y.,
Tong S.M.,
Lai K.C., Hu H.C., Yuen M.F., Hui
C.K. and Lam S.K.,
Rabeprazole-based 3-day and 7-day triple therapy vs
omeprazole-based 7-day triple therapy for the treatment
of Helicobacter pylori infection, Alimentary
Pharmacology and Therapeutics. 2001, 15(12):
1959-1965.
|
|
Wong W.M.,
Wong B.C.Y.,
Xia H.H.X.,
Tang V.S., Lai
K.C., Hu
H.C., Yuen
M.F., Chan
C.K. and Lam
S.K., An evaluation of a rapid urine test for the
diagnosis of Helicobacter pylori infection in the Chinese
population, Alimentary
Pharmacology and Therapeutics. 2002, 16(4):
813-817.
|
|
Wong W.M.,
Wong B.C.Y.,
Tang V.S.Y., Wong K.W., Li T.M., Cheung K.L., Fung
F.M.Y., Lai
K.C., Hu
H.C., Chan
C.K., Xia H.H.X.
and Lam S.K.,
Evaluation of three near patient tests for the diagnosis
of Helicobacter pylori infectino in Chinese population,
The
Hong Kong Practitioner. 2002, 24 (2 suppl):
43.
|
|
Wong W.M.,
Gu Q., Lam
S.K., Fung
F.M.Y., Lai
K.C., Xia H.H.X.,
Hu H.C.
and Wong B.C.Y.,
Randomized controlled trial of rabeprazole, levofloxacin
and rifabutin triple therapy versus rabeprazole-based
quadruple therapy as a rescue treatment for failure
of Helicobacter pylori eradication with standard tiple
therapies, Gastroenterology.
2002, 122 (4 suppl 1): A587.
|
|
Wong W.M.,
Lai K.C., Lau C.P., Hu H.C., Chen W.H., Wong B.C.Y., Hui W.M., Wong
Y.H., Xia H.H.X.
and Lam S.K.,
Upper gastrointestinal evaluation of Chinese Patients
with non-cardiac chest pain, Alimentary
Pharmacology and Therapeutics. 2002, 16(3):
465-471.
|
|
Wong W.M.,
Lai K.C., Lau C.P., Hu H.C., Chen W.H., Wong B.C.Y., Hui W.M., Wong
Y.H., Xia H.H.X.
and Lam S.K.,
Upper gastrointestinal evaluation of Chinese patients
with noncardiac chest pain, The
Hong Kong Practitioner. 2002, 24 (2 suppl):
44.
|
|
Xia H.H.X.,
Wong B.C.Y.,
Wong K.W., Wong S.Y., Wong
W.M., Lai K.C.,
Hu H.C.,
Chan C.K. and
Lam S.K., Clinical
and endoscopic characteristics of non-Helicobacter
pylori, non-NSAID duodenal ulcers: a long-term prospective
study, Alimentary
Pharmacology and Therapeutics. 2001, 15(12):
1875-1882.
|
|
Xia H.H.X.,
Wong B.C.Y.,
Wong W.M.,
Tang V.S., Cheung H.K., Sham F.N., Fung
F.M.Y., Lai
K.C., Hu
H.C., Chan
C.K. and Lam
S.K., Optimal serological tests for the detection
of Helicobacter pylori infection in the Chinese population,
Alimentary
Pharmacology and Therapeutics. 2002, 16(3):
521-526.
|
|
Hu H.C., Wong Y.H., Lai K.C., Hui W.M.,
Lam K.F., Wong B.C.Y., Xia H.H.X., Chan C.K., Wong W.M., Tsang K.W.T. and
Lam S.K., Normal
24-hour ambulatory proximal and distal gastroesophageal
reflux parameters in Chinese, Hong Kong Medical
Journal. Hong Kong, Hong Kong Academy of Medicine
and the Medical Association, 2002, 8: 168-171.
|
|
Hu H.C., Lam K.F., Wong
Y.H., Lam C.L.K.,
Hui W.M.,
Lai K.C., Wong B.C.Y. and
Lam S.K., The
Hong Kong index of dyspepsia: A validated symptom severity
questionnaire for patients with dyspepsia, Journal
of Gastroenterology and Hepatology. Melbourne,
Australia, Blackwell Science, 2002, 17: 545-551.
|
|
Huang X.R., Chun Hui C.W., Chen Y.X., Wong
B.C.Y., Fung
P.C.W., Metz C., Cho
C.H., Hui
W.M., Bucala R., Lam
S.K., Lan H.Y.,
Chun B. and Wong Y., Macrophage migration inhibitory
factor is an important mediator in the pathoenesis
of gastric inflammation in rats, Gastroenterology.
2001, 121(3): 619-630.
|
|
Lai K.C., Lam S.K., Chu
K.M., Wong
B.C.Y., Hui
W.M., Hu
H.C., Lau G.,
Wong W.M.,
Yuen M.F.,
Chan A.O.O., Lai
C.L. and Wong
J., Lansoprazole for the prevention of recurrences
of ulcer complications from long-term low-dose aspirin
use, New
England Journal of Medicine. 2002, 346(26):
2033-2038.
|
|
Wong B.C.Y.,
Wang W.P., So H.L.,
Shin V.Y.,
Wong W.M.,
Fung F.M.Y.,
Liu E.S.L.,
Hui W.M.,
Lam S.K. and
Cho C.H., Epidermal
growth factor and its receptor in chronic active gastritis
and gastroduodenal ulcer before and after Helicobacter
pylori eradication, Alimentary
Pharmacology and Therapeutics. 2001, 15(9):
1459-1465.
|
|
Wong B.C.Y.,
Wang W.H., Wong W.M., Lau
G., Fung F.M.Y., Kung N.N.S., Chu
K.M., Lai K.C., Hu W.H.C., Hu F.L., Liu X.G., Chan
C.K., Yuen M.F., Hui
W.M. and Lam
S.K., Three-day Lansoprazole quadruple therapy
for Helicobacter pylori-positive duodenal ulcers: a
randomized controlled study, Alimentary
Pharmcology and Therapeutics. 2001, 15: 843-850.
|
|
Wong W.M.,
Lai K.C., Lau C.P., Hu
H.C., Chen
W.H., Wong
B.C.Y., Hui
W.M., Wong
Y.H., Xia H.H.X.
and Lam S.K.,
Upper gastrointestinal evaluation of Chinese Patients
with non-cardiac chest pain, Alimentary
Pharmacology and Therapeutics. 2002, 16(3):
465-471.
|
|
Wong W.M.,
Lai K.C., Lau C.P., Hu
H.C., Chen
W.H., Wong
B.C.Y., Hui
W.M., Wong
Y.H., Xia H.H.X.
and Lam S.K.,
Upper gastrointestinal evaluation of Chinese patients
with noncardiac chest pain, The
Hong Kong Practitioner. 2002, 24 (2 suppl):
44.
|
|
Hui W.C.,
A Study on the Potential Effects of Endogenous Nitric
Oxide in the Healing of Acetic Acid-Induced Gastric
Ulcers (MPhil thesis). 2001.
|
| Project Title: | Role of cytokines
and adhesion molecules in the inflammatory response
of bronchiectasis |
| Investigator(s): | Prof.
Ip M.S.M., Prof. Lam W.K., Dr. Shum D.K.Y., Dr. Tsang
K.W.T. |
| Department: | Medicine |
| Source(s) of Funding: | Lee
Wing Tat Cardiothoracic Research and Education Fund |
| Start Date: | January1996 |
| Abstract: |
| To study the profile and actions of cytokines
and cell adhesion molecules in the chronic and acute
on chronic inflammatory response in bronchiectasis. |
| Project Title: | The interaction of
airway secretions and bronchial epithelial cells in
the regulation of airway inflammation in bronchiectasis |
| Investigator(s): | Prof.
Ip M.S.M., Prof. Lam W.K., Dr. Tsang K.W.T. |
| Department: | Medicine |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | July 1998 |
| Abstract: |
| To evaluate pro-inflammatory cytokine release
(IL-6, IL-8, GM-CSF) by bronchial epithelial cells
in the context of chronic bronchial infection; to evaluate
the modification of this release by drugs. |
| Project Title: | The role of cell adhesion
molecule in persistent neutrophil recruitment in bronchiectasis
and in-vitro evaluation of modulating effect of therapeutic
agents |
| Investigator(s): | Prof.
Ip M.S.M., Prof. Lam W.K., Dr. Tsang K.W.T., Dr. Zheng
L. |
| Department: | Medicine |
| Source(s) of Funding: | Hong
Kong Research Grants Council Competitive Earmarked
Research Grants |
| Start Date: | September 1999 |
| Abstract: |
| To investigate the mechanisms by which neutrophils
are persistently recruited into the airways of patients
with idiopathic diffuse bronchiectasis, focussing on
aspects of neutrophil cell adhesion molecule expression
by endothelial cells and epithelial cells in the context
of the biological mileau of patients; to examine the
modulatory effects of drugs on the above mechanisms. |
| Project Title: | Randomised controlled
study of the effectiveness of treatment in mild to
moderate sleep apnoea |
| Investigator(s): | Prof.
Ip M.S.M., Prof. Cooke M.S., Prof. Karlberg J.P.E.,
Dr. Lam C.L.K., Prof. Lam W.K., Dr. Tsang K.W.T., Dr.
Yam L.Y.C. |
| Department: | Medicine |
| Source(s) of Funding: | Health
Services Research Fund |
| Start Date: | December 1999 |
| Abstract: |
| To evaluate the effectiveness of active treatment
(with nasal continuous positive airway pressure or
oral appliance) versus conservative management only
in patients with mild to moderate sleep apnoea |
| Project Title: | Study of the mechanisms
of vascular homeostasis in obstructive sleep apnoea |
| Investigator(s): | Prof.
Ip M.S.M., Prof. Kwong Y.L., Prof. Lam W.K., Dr. Tsang
K.W.T., Dr. Tse H.F. |
| Department: | Medicine |
| Source(s) of Funding: | Hong
Kong Research Grants Council Competitive Earmarked
Research Grants |
| Start Date: | December 2000 |
| Abstract: |
| To evaluate some basic mechanisms with a study
protocol that examines changes in vascular mediators,
platelet activity, vascular reactivity and haemodynamic/breathing
profile during sleep in obstructive sleep apnoea (OSA)
subjects compared to normal controls as well as in
OSA subjects before and after treatment with nasal
continuous positive airway pressure (nCPAP). |
|
Chan L.Y.,
Fong D., Lam C.L., Chan
M.M.W., Say J.T.K., Leung
Y.H., Zheng L., Ooi
C.G.C., Ip
M.S.M., Lam
W.K. and Tsang
K.W.T., Validation of the Hong Kong Chinese version
of St Georges' Respiratory Questionnaire, The Hong
Kong Practitioner. 2002, 23 Suppl 2: 30.
|
|
Ho J.C.M., Hu H.C.,
Lam W.K., Chu L.W., Zheng
L., Tipoe G.L.,
Ooi C.G.C.,
Sun J.Z., Leung Y.H., Ip M.S.M.,
Chan M.M.W.
and Tsang K.W.T.,
The effect of aging on nasal mucociliary clearance,
beat frequency and ultrastructure of respiratory cilia,
Medical Research Conference, University Department
of Medicine, Hong Kong, 2001. The Hong Kong Practitioner.
2001, 23 (suppl 2): 66 (S-RM-5).
|
|
Ip M.S.M.,
Biochemical & cellular aspects of sleep apnea, European
Sleep Research Society Annual Conference, Reykjavik,
Iceland, June 2002. 2002.
|
|
Ip M.S.M.,
Cardiovascular disorders and sleep apnoea-hypopnoea,
16th Asian Pacific Congress on Diseases of the Chest,
Bombay, India, November 2001. 2001.
|
|
Ip M.S.M.,
Challenges in management of COPD in Asia, COPD Today
- Breathing New Life into a Global Problem, Hong Kong,
December 2001. 2001.
|
|
Ip M.S.M.,
Dyspnoea, cough and haemoptysis, In: Ratnaike R (ed.),
An Essential Guide to Geriatric Practice. McGraw
Hill, 2001. 2001.
|
|
Ip M.S.M.,
Lam B., Ng M.M.T.,
Lam W.K., Tsang K.W.T. and
Lam K.S.L.,
Hyperinsulinemia in obstructive sleep apnea, American
Thoracic Society International Conference, San Francisco,
USA, 2001. American Journal of Respiratory & Critical
Care Medicine. 2001, 163(5): A637.
|
|
Ip M.S.M.,
Member of Editorial Board - Chinese Journal of Respiratory
and Critical Care Medicine, 2002. 2002.
|
|
Ip M.S.M.,
Member of Editorial Board - Chinese Journal of Tuberculosis
and Respiratory Disease (China Medical Association),
2001. 2001.
|
|
Ip M.S.M.,
Member of Editorial Board, Chinese Journal of Tuberculosis
and Respiratory Disease (China Medical Association).
2001.
|
|
Ip M.S.M.,
Member of International Advisory Board to Davidson
Principles and Practice of Medicine. 19th Edition.
Churchill Livingstone.2002. 2002.
|
|
Ip M.S.M.,
Member of International Advisory Board, Davidson
Principles and Practice of Medicine. 19th Edition.
Churchill Livingstone. 2002. 2001.
|
|
Ip M.S.M.,
Non-cystic fibrosis bronchiectasis-conventional & new
innovative medical management, 16th Asian Pacific
Congress on Diseases of the Chest, Bombay, India, November
2001. 2001.
|
|
Ip M.S.M.,
Obstructive sleep apnoea and cardiovascular disease,
Annual Scientific Meeting, Hong Kong Society of
Sleep Medicine, March 2002. 2002.
|
|
Ip M.S.M.,
Pneumonia in Asian Countries, 16th Asian Pacific
Congress on Diseases of the Chest, Bombay, India, November
2001. 2001.
|
|
Ip M.S.M.,
Lam B., Mok W.Y.W.,
Ip T.Y. and
Lam W.K., Prevalence
of sleep disordered breathing in middle-aged Chinese
women in Hong Kong, American Thoracic Society International
Conference, San Francisco, USA, 2001. American Journal
of Respiratory & Critical Care Medicine. 2001,
163(5): A636.
|
|
Ip M.S.M.,
Sleep apnoea - East meets West, CHEST 2001, Philadelphia,
USA, November 2001. 2001.
|
|
Ip M.S.M.,
Sleep apnoea - the Asian Perspective, CHEST 2001,
Philadelphia, USA, November 2001. 2001.
|
|
Ip M.S.M.,
Sleep apnoea in Asia, 16th Asian Pacific Congress
on Diseases of the Chest, Bombay, India, November 2001.
2001.
|
|
Ip M.S.M.,
Sleep disordered breathing, 16th Asian Pacific Congress
on Diseases of the Chest, Bombay, India, November 2001.
2001.
|
|
Ip M.S.M.,
Tipoe G.L.,
Leung T.M.,
Zheng L., Shum D.K.Y.,
Tsang K.W.T.
and Lam W.K.,
Sputum sol in bronchiectasis stimulates IL-6 production
from bronchial epithelial cells, American Thoracic
Society International Conference, San Francisco, USA,
2001. American Journal of Respiratory & Critical Care
Medicine. 2001, 163(5): A467.
|
|
Lam B., Ooi C.G.C.,
Peh W., Lam W.K.
and Ip M.S.M.,
Do obstructive sleep apnea(OSA) subjects have smaller
upper airway?, Chest. 2001, 120(4)(Suppl): 303S.
|
|
Lam B. and Ip
M.S.M., Obstructive sleep apnoea and cardiovascular
complications, Clinical Pulmonary Medicine.
2002, 9: 171-176.
|
|
Lam B., Ooi C.G.C.,
Sam K., Lam W.K.,
Tsang K.W.T.
and Ip M.S.M.,
Upper airway change after oral appliance in obstructive
sleep apnoea patients - difference exist in good and
poor responders, Medical Research Conference, University
Department of Medicine, Hong Kong, 2001. The Hong Kong
Practitioner. 2001, 23(suppl 2): 27 (G-RM-6).
|
|
Lam C.L., Lam W.K.,
Wong M.P.,
Chung L.P., Ip
M.S.M., Tsang
K.W.T., Chau W.S., Suen W.S. and Chiu S.W., Establishment
and application of primary lung cancer cell lines (The
HKULC Series) with local Chinese characteristics in
Hong Kong, Joint Annual Scientific Meeting, Hong
Kong Thoracic Society, Chinese Thoracic Society and
American College of Chest Physicians, Hong Kong. 2002.
Abstract pp.26.
|
|
Lam C.L., Lam W.K.,
Ip M.S.M.,
Tsang K.W.T.,
Lam B., Yan C.P.K.,
Ho J.C.M., Ip S. and Wong M.K.Y., The combined use
of gemcitabine and ifosfamide in patients with Stage
III or IV non-small cell lung cancer (NSCLC), Medical
Research Conference, University Department of Medicine,
Hong Kong, 2002. The Hong Kong Practitioner. 2002,
24(2): 55 (C-RC-3).
|
|
Lam C.L., Lam W.K.,
Ip M.S.M.,
Tsang K.W.T.,
Lam B., Ho J.C.M., Ip S. and Wang J.K.L., The use of
gemcitabine and cisplatin in Chinese patients with
advanced non-small cell lung carcinoma (NSCLC), Medical
Research Conference, University Department of Medicne,
Hong Kong, 2001. The Hong Kong Practitoner. 2001,
23(suppl 2): 24(G-RM-1).
|
|
Ooi C.G.C.,
Khong P.L.,
Ho I.W.T., Cheung F.T.F., Ip
M.S.M., Lam
W.K. and Ngan H., A CT quantiative morphometric-functional
correlative study of silicosis, European Congress
of Radiology, Vienna, Austria, 1-5 March 2002.
|
|
Shum D.K.Y.
and Ip M.S.M.,
Degradation of lung matrix proteoglycans in bronchiectasis,
In: H.G. Garg, P.J. Roughley, C.H. Hales (eds), Proteoglycans
and Lung Disease. Lung Biology in Health and Disease.
New York, Marcel Dekker, 2002, 323-333.
|
|
Tan W.C., Seale P., Chaoenrantanakul S., Hardiarto
M., Ip M.S.M.,
Mahayiddin A., Zhong N.S., Schau B. and Iqbal A., Chronic
obstructive pulmonary disease (COPD) prevalence in
7 Asian Countries : projections based on the COPD prevalence
model, American Thoracic Society International Conference,
San Francisco, USA, 2001. American Journal of Respiratory
& Critical Care Medicine. 2001, 163(5): A81.
|
|
Tsang K.W.T.,
Ip S.K., Leung R., Tipoe G.L., Chan S.L., Shum I.H.,
Ip M.S.M.,
Yan C., Fung P.C., Chan
M.M.W. and Lam
W.K., Enhaled nitric oxide: the effects of age,
gender and body size, Lung.
2001, 179(2): 83-91.
|
|
Tsang K.W.T.,
Ip S.K., Leung R., Tipoe
G.L., Chan S.L., Shum I.H., Ip
M.S.M., Yan C., Fung
P.C.W., Chan-Yeung M. and Lam W., Exhaled nitric
oxide: The effects of age, gender and body size, Lung.
2001, 179: 83-91.
|
|
Tsang K.W.T.,
Lam B., Ooi C.G.C.,
Ho J.C.S.,
Chan S., Yan C., Leung R., Ip
M.S.M., Chan
M.M.W. and Lam
W.K., Inhaled fluticasone therapy reduces exacerbation
frequency and sputum production in bronchiectasis (BX).,
The Hong Kong Practitioner. 2002, 24(2): 58.
|
|
Wang J.K.L., Lam
W.K., Ho J.C.M., Ip
M.S.M. and Tsang
K.W.T., Paclitaxel and carboplatin in advanced
non-small cell lung cancer (NSCLC), Hong Kong experience,
Medical Research Conference, University Department
of Medicine, Hong Kong, 2001. The Hong Kong Practitioner.
2001, 23(suppl 2): 25 (G-RM-3).
|
|
Wong M., Chan S., Yan C., Chan
M.M.W., Ho
J.C.S., Lam B., Ooi
C.G.C., Ip
M.S.M., Lam
W.K. and Tsang
K.W.T., Inhaled steroid therapy is associated with
improvement in quality of life among bronchiectasis
patients., The Hong Kong Practitioner. 2002,
24(2): 60.
|
|
Zheng L., Lam W.K.,
Shum H.Y.I.,
Tipoe G.L.,
Yan C.P.K.,
Leung Y.H.,
Sun J.Z., Ooi C.G.C., Ip M.S.M.
and Tsang K.W.T.,
Expression of matric matelloproteinase-8 and 9 is raised
in the airways of patients with bronchiectasis in vivo,
The Hong Kong Practitioner. 2001, 23(Suppl 2):
64.
|
|
Zheng L., Lam W.K.,
Shum H.Y.I.,
Tipoe G.L.,
Yan C.P.K.,
Leung Y.H.,
Sun J.Z., Ooi C.G.C., Ip M.S.M.
and Tsang K.W.T.,
Over expression of matrix metalloproteinase-8 (MMP-8)
and -9 (MMP-9) in bronchiectatic airways in vivo, Medical
Research Conference, University Department of Medicine,
Hong Kong, 2001. The Hong Kong Practitioner. 2001,
23 (suppl 2): 64 (S-RM-1).
|
|
Zheng L., Shum
H.Y.I., Lam
W.K., Tipoe
G.L., Yan C.P.K.,
Ooi C.G.C.,
Ho J.C.M., Fung
P.C.W., Ip
M.S.M. and Tsang
K.W.T., Overexpression of matrix metalloproteinase-8
(MMP-8) and-9 in bronchiectatic airways in vivo, American
Journal of Respiratiry and Critical Care Medicine.
2001, 163(5): A671.
|
|
Ip M.S.M.,
Lam B., Mok W.Y.W.,
Ip T.Y.
and Lam W.K.,
Prevalence of sleep disordered breathing in middle-aged
Chinese women in Hong Kong, American Thoracic Society
International Conference, San Francisco, USA, 2001.
American Journal of Respiratory & Critical Care Medicine.
2001, 163(5): A636.
|
|
Lam C.L., Lam W.K.,
Ip T.Y.,
Ooi C.G.C.,
Lam B., Ip S., Wang J., Ho J.C.M., Yan C., Chan
L.Y., Zheng L., Man
R.Y.K. and Tsang
K.W.T., Effects of herbal preparation, coriolus
versicolor Yun-Zhi, on non-small cell lung cancer (NSCLC),
Medical Research Conference, University Department
of Medicine, Hong Kong. 2001.
|
|
Jiang X.,
Lam S.K., Fan
X.M., Lin M.C.,
Kung H. and
Wong B.C.Y.,
Specific COX-2 inhibitor suppresses NF-kB activation
by inhibition of RelA/p65 nuclear translocation in
gastric cancer, Gastroenterology. 2002, 122(4
Suppl 1): A240.
|
|
Jiang X.,
Lam S.K., Tu S., Lin
M.C., Kung
H. and Wong
B.C.Y., Specific COX-2 inhibitor suppresses anchorage-independent
cell growth through AP-1/MAPK pathway in gastric cancer
(oral presentation), Gastroenterology. 2002,
122(4 Suppl 1).
|
|
Wong B.C.Y.,
Jiang X.
and Lam S.K.,
Cyclooxygenase and gastric cancer, Journal of Modern
Digestion and Intervention. 2001, 6 (6): 23-25.
|
|
Wong B.C.Y.,
Jiang X.
and Lam S.K.,
Role of cyclooxygenase-2 and gastric cancer. (in Chinese),
Journal of Modern Digestion and Intervention.
2002, 7(5): 69-70.
|
|
Jiang X.,
Lam S.K., Fan
X.M., Lin M.C.,
Kung H. and
Wong B.C.Y.,
Specific COX-2 inhibitor suppresses NF-kB activation
by inhibition of RelA/p65 nuclear translocation in
gastric cancer, Gastroenterology. 2002, 122(4
Suppl 1): A240.
|
|
Jiang X.,
Lam S.K., Tu S., Lin
M.C., Kung
H. and Wong
B.C.Y., Specific COX-2 inhibitor suppresses anchorage-independent
cell growth through AP-1/MAPK pathway in gastric cancer
(oral presentation), Gastroenterology. 2002,
122(4 Suppl 1).
|
|
Wong B.C.Y.,
Jiang X.
and Lam S.K.,
Cyclooxygenase and gastric cancer, Journal of Modern
Digestion and Intervention. 2001, 6 (6): 23-25.
|
|
Wong B.C.Y.,
Jiang X.
and Lam S.K.,
Role of cyclooxygenase-2 and gastric cancer. (in Chinese),
Journal of Modern Digestion and Intervention.
2002, 7(5): 69-70.
|
|
Jiang
H., Effects of Estrogen on Human Catechol-O-Methyltransferasen
(PhD thesis). 2001.
|
|
Yu C.M., Chau M.C., Sanderson
J.E., Fan Y.Y.,
Tang M.O.,
Fung W.H., Lin
H., Kong
S.L., Lam
Y.M., Hill M.R. and Lau
C.P., Tissue Doppler echocardiographic evidence
of reverse remodeling and improved synchronicity by
simultaneously delaying regional contraction after
biventricular pacing therapy in heart failure., In:
, Circulation. 2002, 105: 438-45.
|
|
Kumana C.R.,
Tai Y.C., Kong Y., Ma E.C.W., Kou
M., Lee
R.A., Cheng
V.C.C., Chiu
S.S.S. and Seto
W.H., Curtailing unnecessary vancomycin usage in
a hospital with high rates of methicillin resistant
Staphylococcus aureus infection, British
Journal Clinical Pharmacology. 2002, 52: 427-432.
|
| Project Title: | Cyclosporin dosage
and co-treatment with diltiazem in renal transplant
patients |
| Investigator(s): | Prof.
Kumana C.R., Prof. Chan D.T.M., Prof. Janus E.D., Dr.
Lauder I.J., Dr. Li C.S., Dr. Tong M.K.L., Prof. Walley
T. |
| Department: | Medicine |
| Source(s) of Funding: | Health
Services Research Fund
Hospital
Authority |
| Start Date: | November 1997 |
| Abstract: |
| To determine whether in renal transplant patients,
co-treatment with diltiazem results in a clinically
and statistically significant reduction in cyclosporin
(Neoral-R) dosage requirement and improved overall
cost-effectiveness of treatment. |
|
Chau J., Cheung
B.M.Y., McGhee
S.M., Lauder
I.J., Lau C.P.
and Kumana C.R.,
The CARE study applied to Hong Kong patients - a cost-benefit
analysis, 7th Scientific Meeting of the Hong Kong
Pharmacology Society in Association with the Zhejiang
Pharmacological Society, Hong Kong 2001.
|
|
Cheung B.M.Y.,
Ho G.Y.Y., Ng P.P.Y., McGhee
S.M., Kumana
C.R. and Lau
C.P., Change in ambulatory blood pressure in hypertensive
patients is related to sodium intake, 2nd Congress
of Asian-Pacific Society of Hypertension, Pattaya 2001.
|
|
Cheung B.M.Y.,
Law C.Y., Tam S.C.F., Kumana C.R.
and Lau C.P.,
Plasma renin and aldosterone in patients with essential
hypertension, 7th Scientific Meeting of the Hong
Kong Pharmacology Society in Association with the Zhejiang
Pharmacological Society, Hong Kong 2001.
|
|
Cheung B.M.Y.,
Lam T.C., Law C.Y.,
Kumana C.R.
and Lau C.P.,
The relationship between blood pressure and obesity
in Hong Kong Chinese, 2nd Congress of Asian-Pacific
Society of Hypertension, Pattaya 2001.
|
|
Kumana C.R.,
Antibiotic Guidelines in Hospitals, P.D. Hinduja
National Hospital and Medical Research Centre.
2001.
|
|
Kumana C.R.,
Antibiotic Policies, Challenges and Opportunities
in Pathology. 2001.
|
|
Kumana C.R.,
Asian Clinical Trials, Drug Information Association
Meeting, The Hong Kong Academy of Medicine. 2001.
|
|
Kumana C.R.,
Chairman of the Organizing Committee, 9th International
Symposium of the Pacific Rim Association for Clinical
Pharmacogenetics, 19-20 October 2001, Hong Kong.
2002.
|
|
Kumana C.R.,
Chloramphenicol Metabolism and Bone Marrow Toxicity,
Symposium Speaker, 9th International Symposium of
the Pacific Rim Association for Clinical Pharmacogenetics,
19-20 October 2001, Hong Kong. 2001, S1.1.
|
|
Kumana C.R.,
Tai Y.C., Kong Y., Ma E.C.W., Kou
M., Lee R.A.,
Cheng V.C.C.,
Chiu S.S.S.
and Seto W.H.,
Curtailing unnecessary vancomycin usage in a hospital
with high rates of methicillin resistant Staphylococcus
aureus infection, British
Journal Clinical Pharmacology. 2002, 52: 427-432.
|
|
Kumana C.R.,
Cyclosporin A drug interaction - a friend or a foe,
Annual Scientific Meeting of Hong Kong Society of
Transplantation. 2002.
|
|
Kumana C.R.,
Invited Speaker, 2001 Final M.Med (Internal Medicine)
/ MRCP(UK) Part 2 Written & Clinical Preparatory Course,
Graduate School of Medical Studies, The National University
of Singapore, 15-28 April 2001. 2002.
|
|
Kumana C.R.,
New medications and their side effects, Recent Advances
in Diaetic Drugs English Chapter 4th Gathering.
2001.
|
|
Kumana C.R.,
Cheung B.M.Y.
and Lauder I.J.,
Statins benefit Coronary Heart Disease Patients more
than Hypercholesterolaemic Subjects: Inferences Based
on NNT, 11th international Congress on Cardiovascular
Pharmacotherapy - Montreal Cardiovascular Drugs and
Therapy. 2002, 16(Suppl 1): 49-P310.
|
|
Kumana C.R.,
Sudden Unexpected Death in Epilepsy, Hong Kong Association
of Critical Care Nurses. 2001.
|
|
Li N., Kumana
C.R., Cheung
B.M.Y., Chau J., Liu C.L. and Fan
S.T., Liver volume dependent C3-dydroxylation of
diazepam metabolism, Journal of Clinical Pharmacology.
2001, 41: 1014-33.
|
| Project Title: | To determine the genetic
determinants of bone mass and osteoporosis in southern
Chinese women |
| Investigator(s): | Prof.
Kung A.W.C., Dr. Ho A.Y.Y. |
| Department: | Medicine |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | November 2000 |
| Abstract: |
| To determine the polymorphic distribution of
collagen I-alpha1 gene and transforming growth factor
(TGF-beta1) gene in healthy southern Chinese women;
to determine the association of collagen I-alpha1 gene
and TGF-beta1 gene with bone mineral density and osteoporosis
in southern Chinese women. |
| Project Title: | To determine the effect
of phytoestrogen on bone mineral density in Southern
Chinese women |
| Investigator(s): | Prof.
Kung A.W.C., Dr. Ho A.Y.Y. |
| Department: | Medicine |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | November 2001 |
| Abstract: |
| To assess the amount of phytoestrogen intake
in Chinese women in Hong Kong; to determine the association
of phytoestrogen intake and bone mineral density (BMD)
in Chinese women in Hong Kong; to determine the effect
of supplementation of soy protein on biochemical bone
markers and BMD in Chinese women in Hong Kong. |
|
Koh L.K.H., Ben Sedrine W., Torralba T.P., Kung
A.W.C., Fujiwara S., Chau S.P., Huang Q.R.,
Rajatanavin R., Tsai K.S., Park H.M. and Reginister
J.Y., A simple tool to identify Asian women at increased
risk of osteoporosis, Osteoporosis International.
2001, 12: 699-705.
|
|
Kung A.W.C.,
A simple clinical tool to identify Asian women with
osteoporosis, J Women's Health Gender-Based Med
2001. 10(4): Abstract 406.
|
|
Kung J.W., Lao
T.T.H., Chau M.T., Tam S.C.F., Low
L.C.K. and Kung
A.W.C., Mild iodine deficiency and thyroid
disorders in Hong Kong, Hong Kong Medical Journal.
2001, 7(4): 414-420.
|
|
Lau K.S., Chan V.N.Y. and
Kung A.W.C.,
Genetic Mapping for thyrotoxic Periodic Paralysis,
Second International Huaxia Congress of Endocrinology,
Hong Kong, December 2001.
|
|
Woo Y.C., Leung J.Y.Y., Chow W.S. and Kung
A.W.C., Thrombocytopeina and thyotoxicions,
Medical Progress. 2002, 29(4): 26-27.
|
| Project Title: | Provision of purine
analogues for the treatment of patients with chronic
lymphoid malignancies |
| Investigator(s): | Prof.
Kwong Y.L., Prof. Liang R.H.S. |
| Department: | Medicine |
| Source(s) of Funding: | S.K.
Yee Medical Foundation Grant |
| Start Date: | July 1997 |
| Abstract: |
| To provide purine analogues for the treatment
of patients with chronic lymphoid malignancies who
cannot otherwise afford the drugs. |
| Project Title: | Patterns of alleleic
loss in natural killer cell lymphoma |
| Investigator(s): | Prof.
Kwong Y.L. |
| Department: | Medicine |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | November 2000 |
| Abstract: |
| To study the definition of the patterns of
alleleic loss in natural killer cell lymphoma. |
|
Au W.Y., Kwong Y.L.
and Ma E.S.K.,
Acute myeloid leukemia after Dengue fever in a patient
with Hemoglobin H disease, Haematologica. 2001,
86: E17.
|
|
Au W.Y., Ma E.S.K. and
Kwong Y.L.,
Disseminated hepatosplenic mycobacterial infection
masking myeloproliferative diseases as leukemoid reaction:
a diagnostic pitfall, Leukemia and Lymphoma.
2001, 42(4): 805-808.
|
|
Au W.Y., Kwong Y.L.
and Ma E.S.K.,
Myeloproliferatie disease masquerading as leukemoidreaction
secondary to disseminated mycobacterial infection,
Leukemia and Lymphoma. 2001, 42: 805-808.
|
|
Au W.Y., Lie A.K.W., Kwong Y.L.,
Shek T.W.H.,
Hawkins B.R.,
Lai K.N., Tang S.C.W., Lo C.M., Fan
S.T., Liu C.L.,
Chan G.C.F.,
Chau M.C.,
Chiu S.W. and
Liang R.H.S.,
Post-transplantation lymphoproliferative disease in
Chinese: the Queen Mary Hospital experience in Hong
Kong, Leukemia and Lymphoma. 2002, 43: 1405-14September .
|
|
Au W.Y., Lie A.K.W., Liang R.H.S.,
Chan G.C.F.
and Kwong Y.L.,
Sustained and Repeated Response of Relapsed Acute Promyelocytic
Leukaemia to Intravenous or Oral Arsenic Trioxide,
7th Medical Research Conference, Hong Kong, 26-27
January 2002. 24(2): 46.
|
|
Chim J.C.S.,
Liang R.H.S.,
Wong A.S.Y.
and Kwong Y.L.,
Methylation profiling in acute leukaemia., American
Association for Cancer Research Satellite Meeting on
cancer and chromosomal organization : Epigenetics of
Cancer. San Francisco, USA.. 2001.
|
|
Hu Y.,
Lam K.Y., Law S.Y.K.,
Wan T.S.K.,
Ma E.S.K.,
Kwong Y.L.,
Chan L.C.,
Wong J. and
Srivastava G.,
Establishment, characterization, karyotyping, and comparative
genomic hybridization analysis of HKESC-2 and HKESC-3:
two newly established human esophageal squamous cell
carcinoma cell lines, Cancer
Genetics and Cytogenetics. 2002, 135: 120-127.
|
|
Lau G., Leung A.Y.H.,
Au W.Y., Kwong Y.L.,
Lie A.K.W.,
Liang R.H.S.,
Hou J., Nanji A.A.
and Fong D.Y.T.,
High HBV DNA viral load is the most significant risk
factor for hepatitis B reactiation in hepatitis B surface
antign positive patients treated with autologous hematopoietic
stem cell transplantation, Blood.
2002, 99: 2324-2330.
|
|
Lau G., Au W.Y., Lie
A.K.W., Fong D.Y.T., Kwong
Y.L. and Liang
R.H.S., Reduction of hepatitis due to HBV reactivation
in HbsAg positive patients undergoing allogeneic bone
marrow transplantation with pre-emptive lamuvidine
treatment., 52th Annual Meeting of American Association
for study of Liver disease.. 2001.
|
|
Lau G.K.K.,
Leung A.Y.H.,
Fong D.Y.T.,
Au W.Y., Kwong Y.L.,
Lie A.K.W.,
Hou J.L., Wen Y.M., Nanji
A.A. and Liang
R.H.S., High hepatitis B virus (HBV) DNA viral
load as the most important risk factor for HBV reactivation
in patients positive for HBV surface antigen undergoing
autologous hematopoietic cell transplantation, Blood.
2002, 99: 2324-2330.
|
|
Leung A.Y.H.,
Suen C., Chow C.H.,
Liang R.H.S.,
Lie A.K.W.
and Kwong Y.L.,
Quantitative and genotypic analysis of polyoma BK viruria
during hemorrhagic cystitis complicating bone marrow
transplantation., 43rd Annual Meeting of American
Society of Hematology, Orlando, USA.. 2001.
|
|
Man C., Lam W.K.,
Liang R.H.S.
and Kwong Y.L.,
Genetic imbalances in lung cancer in Hong Kong by comparative
genomic hybridization, Chest. 2001, 120(4)(suppl):
317S.
|
|
Man C.W.Y.,
Lam W.K., Liang R.H.S. and
Kwong Y.L.,
Genetic imbalances in lung cancer in Hong Kong by comparative
genomic hybridisation., Annual International Conference
of American College of Chest Physicians. Philadelphia,
USA,. 2001.
|
|
Rocha K.A.,
Cheung P.T.,
Lau Y.L., Kwong Y.L.
and Chan G.C.F.,
In Vitro Study of the Effect of Arsenic Trioxide in
Childhood Neuroblastoma, Joint Annual Scientific
Meeting 2001, The Hong Kong Paediatirc Society and
Hong Kong Paediatric Nurses Association, Hong Kong,
13 October 2001. 47.
|
|
Siu L.L.P., Chan J.K.C., Wong K.F. and Kwong
Y.L., Specific patterns of gene methylation
in natural killer cell lymphomas : p73 is consistently
involved., American
Journal of Pathology. 2002, 160: 59-66.
|
|
Chan A.O.O., Yuen
M.F., Hui C.K., Tso
W.K. and Lai
C.L., A prospective study regarding the complications
of transcatheter intraarterial lipiodol chemoembolization
in patients with hepatocellular carcinoma., Cancer.
2002, 94(6): 1747-1752.
|
|
Lai C.L.,
(1) Advances in the treatment of HBV infection (2)
Natural history of chronic hepatitis B (3) Acceptance
of liver biopsies, 2nd Indian Ocean Conference on
Viral Hepatitis organised by Fremantle Hospital & Health
Services, Perth, Australia, 25 May 2002. 2002.
|
|
Lai C.L.,
Clinical application of the line probe assay, Innogenetics,
HBV Distributor Training "INNO LiPA HBV Genotyping,
Precore and Resistance Testing" organised by Innogenetics
Biotechnology for Healthcare, 24 February 2002, Bangkok,
Thailand. 2002.
|
|
Lai C.L.,
Clinical outcomes with long-term lamivudine therapy,
37th Annual Meeting of the European Association
for the Study of the Liver "The Spectrum of Chronic
Hepatitis B: Managing the Diversity of Patients", 20
April 2002, Madrid, Spain. 2002.
|
|
Lai C.L.,
Cost effectiveness of screening for hepatocellular
carcinoma, "Symposium in Medical Sciences - 21st
Century Health Care in Hong Kong: A New Era", Faculty
of Medicine, The University of Hong Kong, Hong Kong,
2 June 2002. 2002.
|
|
Lai C.L.,
HCV - assessing the risk of cirrhosis and hepatocellular
carcinoma, 4th Scientific Congress of Academy of
Insurance Medicine of Asia, 4-7 November 2001, Ho Chi
Minh City, Vietnam. 2001.
|
|
Lai C.L.,
L-nucleosides, HEP DART 2001, Frontiers in Drug
Development for Viral Hepatitis, 16-20 December 2001,
Maui, Hawaii, USA. 2001.
|
|
Lai C.L.,
Lamivudine - 5 years data, Symposium on "Chronic
Hepatitis B Management: Sharing Best Practice" organised
by the Hong Kong Association for the Study of Liver
Diseases, 9 May 2002, Hong Kong. 2002.
|
|
Lai C.L.,
New Era in Hepatitis B Management, National Congress
of the Indonesian Society of Internal Medicine, Surabaya,
Indonesia. 2001.
|
|
Lai C.L.,
Recent research on the treatment of chronic hepatitis
B, 6th Hong Kong Medical Forum, Department of Medicine,
Faculty of Medicine, The University of Hong Kong, 7-8
July 2001, Hong Kong Convention & Exhibition Centre,
Hong Kong. 2001.
|
|
Lai C.L.,
The treatment of chronic hepatitis B, 11th Annual
Bristol-Myers Squibb Award for Distinguished Achievement
in Infectious Diseases Colloquium, 15 November 2001,
Newport, USA. 2001.
|
|
Lai C.L.,
Therapeutics advances in chronic hepatitis B: update
on lamivudine therapy, 10th International Congress
on Infectious Diseases "Hepatiitis Disease Management
- Integrating Prevention, Diagnostics and Therapeutics,
11-14 March 2002, Singapore. 2002.
|
|
Lai C.L.,
Treatment of HBV infection, 2nd Asian Pacific Digestive
Week Gastroenterology Postgraduate Course "Viral Hepatitis
and Gastric Cancer in the Molecular Age" of the World
Congress of Gastroenterology, 24 February - 1 March
2002, Bankgok, Thailand. 2002.
|
|
Lai C.L.,
Treatment of HBV infection, Seminar on "Current
treatments on hepatitis B and recent development for
anti-HBV therapy" organised by LG Chem Investment Ltd.
2002.
|
|
Lai C.L.,
Treatment of chronic hepatitis B virus infection, Academic
Seminar organised by the Associacao Chinesa dos Profissionais
de Medicina de Macau, 20 January 2002, Macau. 2002.
|
|
Lai K.C., Lam S.K., Chu
K.M., Wong
B.C.Y., Hui
W.M., Hu H.C.,
Lau G., Wong W.M., Yuen M.F., Chan
A.O.O., Lai C.L.
and Wong J.,
Lansoprazole for the prevention of recurrences of ulcer
complications from long-term low-dose aspirin use,
New
England Journal of Medicine. 2002, 346(26):
2033-2038.
|
|
Liu C.L., Fan S.T., Lo
C.M., Lam B.K.Y.,
Wei W.I., Lai C.L. and
Wong J., The
use of right lobe liver grafts from living donors in
high-urgency patients (Abstract), 10th Congress
of the European Society for Organ Transplantation and
12th Congress of the European Transplant Coordinators
Organisation, Lisboa, Portugal, 6-11 October, 2001.
|
|
Lo C.M., Fan S.T., Liu
C.L., Yong B.H., Lai
C.L., Lau
G., Wei W.I.,
Tam P.K.H.,
Tsoi N.S., Ng I.O.L.,
Young K., Chan J.K.F., Tso W.K., Yuen K.Y. and Wong
J., Ten-year experience with liver transplantation
at Queen Mary Hospital, Hong Kong Medical Journal.
2002, 8: 240-244.
|
|
Ng F.H., Wong W.M.,
Wong B.C.Y.,
Kng C., Wong S.Y., Lai
K.C., Cheng C.S., Yuen W.C., Lam
S.K. and Lai
C.L., Sequential intravenous/oral antibiotic
vs. continuous intravenous antibiotic in the treatment
of pyogenic liver abscess., Alimentary
Pharmacology and Therapeutics. 2002, 16(6):
1083-1September 0.
|
|
Sugauchi F., Orito E., Ichida T., Kato H., Sakugawa
H., Kakumu S., Ishida T., Chutaputti A., Lai
C.L., Ueda R., Miyakawa Y. and Mizokami M.,
Hepatitis B virus of genotype B with or without recombination
with genotype C over the precore region plus the core
gene, Journal
of Virology. 2002, 76(12): 5985-5992.
|
|
To Y.F., Yuen M.F., Poon
R.T.P., Ip W.K., Lai
C.L. and Lau
Y.L., Mannose binding lectin polymorphisms and
hepatitis B infection in Chinese (Poster), 10th
International Congress on Infectious Disease, Singapore,
11-15 March, 2002.
|
|
To Y.F., Yuen M.F., Poon
R.T.P., Ip W.K., Lai
C.L. and Lau
Y.L., Mannose binding lectin polymorphisms and
hepatitis B infection in Chinese, 11th International
Congress of Immunology, Stockholm, Sweden. 2001.
|
|
To Y.F., Yuen M.F., Poon R.T.P., Ip E.W.K., Lai C.L. and
Lau Y.L., Mannose
binding lectin polymorphisms and hepatitis B infection
in Chinese, 11th International Congress of Immunology,
Stockholm, Sweden, 23-27 July 2001(Poster presentation;
FIMSA Travel Award). 2001, Suppl 1.
|
|
Tong T.K., Yeung
J.S.L., Fung D.M., Lai
C.L. and Lau
W.C.S., Alterations of CD8+CD28- T cells in systemic
lupus erythematosus (SLE) and rheumatoid arthritis
(RA), 20th Congress of the ILAR. 2001, W13:
79.
|
|
Yuen M.F.,
Sablon E., Hui C.K., Yuan
H., Decraemer H. and Lai
C.L., Factors associated with hepatitis B virus
DNA breakthrough in patients receiving prolonged lamivudine
therapy., Hepatology.
2001, 34(4 Pt 1): 785-791.
|
|
Yuen M.F.,
Hui C.K., Cheng C.C., Wu
C.H., Lai Y.P. and Lai
C.L., Long-term follow-up of interferon alfa
treatment in Chinese patients with chronic hepatitis
B infection: The effect on hepatitis B e antigen seroconversion
and the development of cirrhosis-related complications.,
Hepatology.
2001, 34(1): 139-145.
|
|
Yuen M.F. and
Lai C.L.,
Treatment of chronic hepatitis B., Lancet Infectious
Diseases. 2001, 1(4): 232-241.
|
|
de Man R.A., Wolters L.M., Nevens F., Chua D., Sherman
M., Lai C.L.,
Gadano A., Lee Y., Mazzotta F., Thomas N. and DeHertogh
D., Safety and efficacy of oral entecavir given for
28 days in patients with chronic hepatitis B virus
infection., Hepatology.
2001, 34(3): 578-582.
|
|
Fung F.M.Y.,
Wong W.M.,
Lam S.K., Yee
Y.K., Hung W.K., Yip W.C., Szeto M.L., Tong
S.M., Lai
K.C., Hu
H.C., Hui C.K. and Wong
B.C.Y., Rabeprazole based 3-day and 7-day triple
therapy vs 7-day omeprazole based triple therapy for
the treatment of Helicobacter pylori infection, Journal
of Gastroenterology and Hepatology. 2001, 16
(9 suppl): A127.
|
|
Gu Q., Wong
W.M., Lam S.K.,
Yin Y., Wang W.H., Fung
F.M.Y., Lai
K.C., Xia
H.H.X., Wong
B.C.Y. and Xiao S.D., One week omeprazole, furazolidone
and amoxycillin rescue therapy after failure of Helicobacter
pylori eradication with standard triple therapies,
Gastroenterology.
2002, 122 (4 suppl 1): A586.
|
|
Hu H.C., Wong Y.H., Lai K.C.,
Hui W.M., Lam K.F., Wong
B.C.Y., Xia
H.H.X., Chan
C.K., Wong
W.M., Tsang
K.W.T. and Lam
S.K., Normal 24-hour ambulatory proximal and distal
gastroesophageal reflux parameters in Chinese, Hong
Kong Medical Journal. Hong Kong, Hong Kong Academy
of Medicine and the Medical Association, 2002, 8: 168-171.
|
|
Hu H.C., Lam K.F., Wong
Y.H., Lam C.L.K.,
Hui W.M., Lai K.C.,
Wong B.C.Y.
and Lam S.K.,
The Hong Kong index of dyspepsia: A validated symptom
severity questionnaire for patients with dyspepsia,
Journal
of Gastroenterology and Hepatology. Melbourne,
Australia, Blackwell Science, 2002, 17: 545-551.
|
|
Lai K.C.,
Lam S.K., Chu K.M., Wong
B.C.Y., Hui
W.M., Hu H.C.,
Lau G., Wong W.M., Yuen M.F., Chan
A.O.O., Lai C.L.
and Wong J.,
Lansoprazole for the prevention of recurrences of ulcer
complications from long-term low-dose aspirin use,
New
England Journal of Medicine. 2002, 346(26):
2033-2038.
|
|
Ng F.H., Wong W.M.,
Wong B.C.Y.,
Kng C., Wong S.Y., Lai
K.C., Cheng C.S., Yuen W.C., Lam
S.K. and Lai
C.L., Sequential intravenous/oral antibiotic vs.
continuous intravenous antibiotic in the treatment
of pyogenic liver abscess., Alimentary
Pharmacology and Therapeutics. 2002, 16(6):
1083-1September 0.
|
|
Wong B.C.Y.,
Lam S.K., Wong W.M., Zheng T., Chen
J.S., Chen B.W., Lai
K.C., Yuen
S.T. and Ho
J.C.Y., Eradicating Helicobacter pylori infection
in general population prevents gastric cancer: 1 7
year prospective randomized placebo-controlled study,
Gstroenterology.
2002, 122 (4 suppl 1): A588.
|
|
Wong B.C.Y.,
Lam S.K., Wong W.M., Feng
R.E., Zheng T.,
Yuen S.T.,
Ho J.C.Y., Leung S.Y., Chen
J.S. and Lai
K.C., Eradication of Helicobacter pylori infection
significantly slows down the progression of precancerous
lesions in high risk population: a 5-year prospective
randomized study, Gastroenterology.
2002, 122 (4 suppl 1): A588.
|
|
Wong B.C.Y.,
Wong W.M.,
Yee Y.K., Hung W.K., Yip A.W., Seto M.L., Li K.F.,
Lau P., Fung F.M.Y.,
Tong S.M.,
Lai K.C.,
Hu H.C., Yuen M.F., Hui
C.K. and Lam S.K.,
Rabeprazole-based 3-day and 7-day triple therapy vs
omeprazole-based 7-day triple therapy for the treatment
of Helicobacter pylori infection, Alimentary
Pharmacology and Therapeutics. 2001, 15(12):
1959-1965.
|
|
Wong W.M.,
Wong B.C.Y.,
Xia H.H.X.,
Tang V.S., Lai
K.C., Hu
H.C., Yuen
M.F., Chan
C.K. and Lam
S.K., An evaluation of a rapid urine test for the
diagnosis of Helicobacter pylori infection in the Chinese
population, Alimentary
Pharmacology and Therapeutics. 2002, 16(4):
813-817.
|
|
Wong W.M.,
Wong B.C.Y.,
Tang V.S.Y., Wong K.W., Li T.M., Cheung K.L., Fung
F.M.Y., Lai
K.C., Hu
H.C., Chan
C.K., Xia H.H.X.
and Lam S.K.,
Evaluation of three near patient tests for the diagnosis
of Helicobacter pylori infectino in Chinese population,
The
Hong Kong Practitioner. 2002, 24 (2 suppl):
43.
|
|
Wong W.M.,
Wong B.C.Y.,
Lu H., Gu Q.,
Yin Y., Wang W.H., Fung
F.M.Y., Lai
K.C., Xia
H.H.X., Xiao D. and Lam
S.K., One-week omeprazole, furazolidone and amoxicillin
rescue therapy after failure of Helicobacter pylori
eradication with standard triple therapies, Alimentary
Pharmacology and Therapeutics. 2002, 16(4):
793-798.
|
|
Wong W.M.,
Gu Q., Lam
S.K., Fung
F.M.Y., Lai
K.C., Xia
H.H.X., Hu
H.C. and Wong
B.C.Y., Randomized controlled trial of rabeprazole,
levofloxacin and rifabutin triple therapy versus rabeprazole-based
quadruple therapy as a rescue treatment for failure
of Helicobacter pylori eradication with standard tiple
therapies, Gastroenterology.
2002, 122 (4 suppl 1): A587.
|
|
Wong W.M.,
Lai K.C.,
Lau C.P., Hu H.C., Chen
W.H., Wong
B.C.Y., Hui
W.M., Wong
Y.H., Xia H.H.X.
and Lam S.K.,
Upper gastrointestinal evaluation of Chinese Patients
with non-cardiac chest pain, Alimentary
Pharmacology and Therapeutics. 2002, 16(3):
465-471.
|
|
Wong W.M.,
Lai K.C.,
Lau C.P., Hu H.C., Chen
W.H., Wong
B.C.Y., Hui
W.M., Wong
Y.H., Xia H.H.X.
and Lam S.K.,
Upper gastrointestinal evaluation of Chinese patients
with noncardiac chest pain, The
Hong Kong Practitioner. 2002, 24 (2 suppl):
44.
|
|
Xia H.H.X.,
Wong B.C.Y.,
Wong K.W., Wong S.Y., Wong
W.M., Lai
K.C., Hu
H.C., Chan
C.K. and Lam
S.K., Clinical and endoscopic characteristics of
non-Helicobacter pylori, non-NSAID duodenal ulcers:
a long-term prospective study, Alimentary
Pharmacology and Therapeutics. 2001, 15(12):
1875-1882.
|
|
Xia H.H.X.,
Wong B.C.Y.,
Wong W.M.,
Tang V.S., Cheung H.K., Sham F.N., Fung
F.M.Y., Lai
K.C., Hu
H.C., Chan
C.K. and Lam
S.K., Optimal serological tests for the detection
of Helicobacter pylori infection in the Chinese population,
Alimentary
Pharmacology and Therapeutics. 2002, 16(3):
521-526.
|
| Project Title: | The mechanism of binding
of IgA to mesangial cells - the pivotal issue of the
pathogenesis of IgA nephropathy |
| Investigator(s): | Prof.
Lai K.N. |
| Department: | Medicine |
| Source(s) of Funding: | Hong
Kong Research Grants Council Competitive Earmarked
Research Grants
RGC
Fundable Projects (Block Grant Funded) |
| Start Date: | November 1998 |
| Abstract: |
| To investigate the mechanisms by which the
"pathogenetic" polymeric IgA (pIgA) from patients with
IgA nephropathy (IgAN) is taken up by the mesangial
cells of the kidney - the first and the essential step
in the development of the nephritis. Emphasis will
be focussed in the binding of pIgA either by specific
immunoglobulin or lectin receptors, or by interaction
through electrostatic charge. Interruption of the
binding will prevent the inflammatory process in the
mesangial cells and, hence, reducing the progression
of glomerular sclerosis and renal failure. |
| Project Title: | The expression of
water channels in human peritoneal and pleural mesothelial
cell in specific disease status |
| Investigator(s): | Prof.
Lai K.N. |
| Department: | Medicine |
| Source(s) of Funding: | RGC
Fundable Projects (Block Grant Funded) |
| Start Date: | November 2000 |
| Completion Date: | October 2001 |
| Abstract: |
| To study two area of mesothelial cell biology,
namely (a) peritoneal mesothelial cells in peritoneal
dialysis and (b) pleural mesothelial cells in serositis. |
| Project Title: | The effects of peritoneal
dialysis fluid on the human peritoneal mesothelium:
focus on water channels (aquaporins) and intercellular
junctions |
| Investigator(s): | Prof.
Lai K.N. |
| Department: | Medicine |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | November 2001 |
| Abstract: |
| To study the physiologic properties of the
peritoneal membrane in different pathologic settings
with special interest in transmembrane and intercellular
water transport. |
|
Au W.Y., Lie A.K.W., Kwong Y.L., Shek T.W.H., Hawkins B.R., Lai K.N., Tang S.C.W., Lo C.M., Fan
S.T., Liu C.L.,
Chan G.C.F.,
Chau M.C.,
Chiu S.W. and
Liang R.H.S.,
Post-transplantation lymphoproliferative disease in
Chinese: the Queen Mary Hospital experience in Hong
Kong, Leukemia and Lymphoma. 2002, 43: 1405-14September .
|
|
Chan D.T.M.,
Leung J.K.H.,
Lai K.N.
and Yung S.S.Y.,
Mechanisms of interaction between anti-DNA antibodies
and human mesangial cells in systemic lupus erythematosus
[presented at the 33rd Annual Meeting of the American
Society of Nephrology], Journal of American Society
of Nephrology. October 11-16, Toronto, Canada,
2001, 11: A2492.
|
|
Chan D.T.M.,
Wong R.W.S.,
Lau W.C.S.,
Tsang E.W.K., Ji Y.L., Mok M.Y., Tong M.K.L., Wong
A.K.M. and Lai
K.N., Prolonged follow-up of patients with
diffuse proliferative lupus nephritis (DPLN) treated
with prednisolone and mycophenolate mofetil (MMF).
[Abstract presented at the Annual Meting of the American
Society of Nephrology, Oct 10-17, 2001, San Francisco,
USA], Journal of the American Society of Nephrolgoy.
2001, 12: 195A.
|
|
Choy C.B.Y.,
Lo W.K., Chan D.T.M., Lui S.L., Tang
S.C.W., Lam M.F., Li
F.K. and Lai
K.N., A randomised prospective comparison of
intermittent versus continuous dosing regimens of intraperitoneal
cefozolin and tobramycin in the treatment of CAPD preitonitis.
[Abstract presented at the Annual Meeting of the American
Society Nephrology, Oct 10-17, 2001, San Francisco,
USA], Journal of the American Society of Nephrology.
2001, 12: 425A.
|
|
Choy C.B.Y.,
Chan D.T.M.,
Li F.K., Lui S.L., Lo
W.K. and Lai
K.N., Long-term outcome of renal transplant
in patients with hepatitis B or C. [Abstract presented
at the European Dialysis and Transplantation Association
XXXIX Congress, July 14-17, 2002, Copenhagen, Denmark],
Nephrology Dialysis Transplantation. 2002, 17(Suppl
7): 314.
|
|
Davison A.M., Barsoum R., Lai
K.N., Mani K., Morad Z. and Rutkowski B., Treatment
strategies for end-stage renal failure in developing
countries, Optimal treatment strategies in end-stage
renal failure (edited by C. Jacobs), Oxford University
Press, Oxford. 2002, 257-302.
|
|
Lai K.N.,
Ho K., Cheung R.C., Lit L.C., Lee S.K., Fung K.S.,
Tong M.K.L. and Lam C.W.K., Effect of low molecular
weight heparin on bone metabolism and hyperlipidemia
in patients on maintenance hemodialysis, International
Journal of Artificial Organs. 2001, 24: 447-455.
|
|
Lai K.N.,
From Handel to Strauss: Water Music, Symposium in
Medical Sciences - 21st Century Health Care in Hong
Kong: A New Era, Grand Opening of the Faculty of Medicine
Building, Faculty of Medicine, The University of Hong
Kong, 1-2 June 2002. 2002.
|
|
Lai K.N.,
IgA Nephropathy, Scientific Symposium on Recent
Advances in Management of Nephropathies by Hong Kong
Nephrology Society, Hong Kong, 18 May 2002. 2002.
|
|
Lai K.N.,
The pathogenetic role of IgA molecule in IgA nephropathy,
9th International Symposium on IgA Nephropathy,
Kyongju, Korea, 1-2 November 2001. 2001.
|
|
Lai K.N.,
The pathogenetic role of anti-dsDNA and its implication
in treatment of lupus nephritis - experience from Hong
Kong, Joint Congress "Challenges & Opportunities
in Pathology" by Royal College of Pathologists of Australasia
and Hong Kong Division of the International Academy
of Pathology, Hong Kong, 4-7 October 2001. 2001.
|
|
Leung J.C.K.,
Lan H.Y., Tang C.S.O., Chan D.T.M. and
Lai K.N.,
Polymeric IgA up-regulates macrophage migration inhibitory
factor (MIF) in human mesangial cell. [Abstract presented
at the Annual Meeting of the American Society of Nephrology,
Oct 10-17, 2001, San Francisco, USA], Journal of
the American Society of Nephrology. 2001, 12: 112A-113A.
|
|
Lui S. .L., Tsang R., Wong D., Chan K. .W., Chan
D.T.M., Fung
P.C.W. and Lai
K.N., Effect of mycophenolate mofetil on severity
of nephritis and nitric oxide production in lupus-prone
MRL/Ipr mice, Lupus. 2002, 11: 411-418.
|
|
Rees L.E., Wood N.A., Gillespie K.M., Lai
K.N., Gaston K. and Mathieson P.W., The interleukin-10-1082
G/A polymorphism: allele frequency in different populations
and functional significance, Cellular and Molecular
Life Sciences. 2002, 59(3): 560-569.
|
|
Tang S.C.W.,
Leung J.C.K.,
Lam C.W., Lam
M.F., Chan D.T.M.
and Lai K.N.,
In vitro studies of aquaporins 1 and 3 expression in
cultured human proximal tubular cells: upregulation
by transferrin but not albumin, American Journal
of Kidney Diseases. 2001, 38(2): 317-330.
|
|
Tang S.C.W.,
Leung J.C.K.,
Chan K.W., Chan Y.Y., Chan D.T.M. and
Lai K.N.,
Induction of interleukin-8 in human proximal tubule
cells: an in vitro and in vivo study. [Abstract presented
at the Annual Meeting of the American Society of Nephrology,
Oct 10-17, 2001, San Francisco, USA], Journal of
the American Society of Nephrology. 2001, 12: 664A-665A.
|
|
Tang S.C.W.,
Kwok T.K., Ho P.L.,
Tang W.M., Chan
D.T.M. and Lai
K.N., Necrotizing fasciitis in a renal transplant
recipient treated with FK 506: the first reported case,
Clinical Nephrology. 2001, 56(6): 481-485.
|
|
Tang S.C.W.,
Lai K.N.
and Sacks S.H., Role of complement in tubulointerstitial
injury from proteinuria, Kidney Blood Pressure Research.
2002, 25(2): 120-126.
|
|
Tang S.C.W.,
Chan D.T.M.,
Li F.K., Choy C.B.Y., Tang
A., Ho Y.W. and Lai
K.N., Spousal renal donor transplantation in
Chinese: a ten-year experience from two regional hospitals
in Hong Kong. [Abstract presented at the European
Dialysis and Transplantation Association XXXIX Congress,
July 14-17, 2002, Copenhagen, Denmark], Nephrology
Dialysis Transplantation. 2002, 17(Suppl 7): 320.
|
|
Tomino Y., Suzuki S., Azushima C., Shou L., Iijima
T., Yagame M., Wang L.N., Chen H.C., Lai
K.N., Tan S.Y. and Kim M.J., Asian multicenter
trials on urinary type IV collagen in patients with
diabetic nephropathy, Journal of Clinical Laboratory
Analysis. 2001, 15: 188-192.
|
|
Tsang K.W.T.,
Leung J.C., Tipoe
G.L., Leung R., Yan C., Ooi
C.G.C., Chan
H.H.L., Fung
P.C.W., Lam
W.K. and Lai
K.N., Aquaporin 3 expression in respiratory
mucosa is down-regulated in bronchiectasis in vivo.,
The Hong Kong Practitioner. 2002, 24(2): 58.
|
|
Tsang K.W.T.,
Leung J.C., Tipoe
G.L., Leung R., Yan C., Ooi
C.G.C., Chan
H.H.L., Fung
P.C.W., Lam
W.K. and Lai
K.N., Aquaporin 3 expression in respiratory
mucosa is down-regulated in bronchiectasis in vivo,
The
Hong Kong Practitioner. 2002, 24: C-RC-8.
|
|
Xiang L., Chan
H.H.L., Leung C.K. and Lai
K.N., The effect of sub-lethal QS755nm lasers
on the expression of p16INK4a, Annales De Dermatologie
et De Venereologie. 2002, 129: 1(2):1S616.
|
|
Yung S.S.Y.,
Liu Z.H., Li L.S., Lai
K.N. and Chan
D.T.M., Emodin ameliorates excessive fibronectin
synthesis by human peritoneal mesothelial cells (HPMC).
[Abstract presented at the Annual Meeting of the American
Society of Nephrology, Oct 10-17, 2001, San Francisco,
USA], Journal of the American Society of Nephrology.
2001, 12: 722A.
|
| Project Title: | Development of the
Chinese (HK) SF-8 health survey |
| Investigator(s): | Dr.
Lam C.L.K., Ms Gandek B. |
| Department: | Family
Medicine Unit of the Department of Medicine |
| Source(s) of Funding: | Health
Assessment Laboratory, U.S.A. |
| Start Date: | June 2001 |
| Abstract: |
| To translate the SF-8 health survey to Chinese;
to evaluate the equivalence of the meaning of the Chinese
SF-8 to those of the original SF-8. |
|
Chan M.M.W.,
Law B., Sheung S.Y. and Lam
C.L.K., Internal consistency, reproducibility,
responsiveness, and construct validity of the Chinese
(HK) version of the asthma quality of life questionnaire,
Quality
of Life Research. The Netherlands, 2001, 10(8):
723-730.
|
|
Hu H.C., Lam K.F., Wong
Y.H., Lam
C.L.K., Hui
W.M., Lai K.C.,
Wong B.C.Y.
and Lam S.K.,
The Hong Kong index of dyspepsia: A validated symptom
severity questionnaire for patients with dyspepsia,
Journal
of Gastroenterology and Hepatology. Melbourne,
Australia, Blackwell Science, 2002, 17: 545-551.
|
|
Lam C.L.K.,
Confucius School of Medicine: the way to great learning,
British Medical Journal. U.K., 2001, 323: 1458-1459.
|
|
Lam C.L.K.
and Gandek B., Cross-cultural adaptation of the SF-36
and SF-12 Physical and Mental Summary Scales on a Chinese
Population, Quality of Life Research
. The
Netherlands, 2001, 10(3): 283.
|
|
Lam C.L.K.,
Presentation on "HRQOL assessment for the elderly in
Hong Kong', Symposium on Quality of Life in Elderly:
Assessment and Intervention. Hong Kong Physiotherapy
Association. October 12, 2001.
|
|
Lam C.L.K.,
Presentation on 'Health-related quality of life assessment
- principles and practice', College of Nursing.
April 3, 2002. Hong Kong. 2002.
|
|
Lam C.L.K.,
Presentation on 'Quality of life measures: concepts
and selection', Second National Quality of Life
Symposium. January 13, 2002. Shenzhen, PR China.
2002.
|
|
Lam C.L.K.,
Presentation on 'Translation & cross-cultural validation
of QoL instruments: An Asian perspective', Quality
of Life Workshop: QoL Assessment in Clinical Trials
for Global Drug Development. Organized by Pharmacia
Singapore Pte Ltd., December 8, 2001, Singapore.
2001.
|
|
Lam C.L.K.,
Rational prescribing for upper respiratory tract infections
(URTI), The Hong Kong Practitioner. Hong Kong,
2002, 24(6): 298-304.
|
|
Lam C.L.K.,
全科医療中的臨床診斷與处理, 載於全科医學概論(梁万年主編),
第九章, 中國北京人民衞生出版社, 2001.
|
|
Murphy D.D. and Lam
C.L.K., Functional needs: agreement between
perception of rural patients and health professionals
in China, Occupational Therapy International.
2002, 9(2): 91-111.
|
|
Tang S.C.W.,
Leung J.C.K.,
Lam C.W.,
Lam M.F., Chan
D.T.M. and Lai
K.N., In vitro studies of aquaporins 1 and 3 expression
in cultured human proximal tubular cells: upregulation
by transferrin but not albumin, American Journal
of Kidney Diseases. 2001, 38(2): 317-330.
|
| Project Title: | Losartan renal protection
study |
| Investigator(s): | Prof.
Lam K.S.L., Dr. Wat N.M.S. |
| Department: | Medicine |
| Source(s) of Funding: | Merck
Research Laboratories, U.S.A. |
| Start Date: | January1997 |
| Abstract: |
| To study the beneficial effect of angiotensin
II receptor blockade on renal function of NIDDM patients
with moderately severe, diabetic nephropathy. |
| Project Title: | Interaction between
the polyol pathway and non-enzymatic glycation in the
pathogenesis of diabetic nephoropathy |
| Investigator(s): | Prof.
Lam K.S.L., Dr. Chung S.S.M., Dr. Chung S.K. |
| Department: | Medicine |
| Source(s) of Funding: | Hong
Kong Research Grants Council Competitive Earmarked
Research Grants |
| Start Date: | October 1998 |
| Abstract: |
| To introduce the AR gene into transgenic mice
to increase the level of this enzyme in the kidney
glomerular cells, to study the effect on the development
of diabetic kidney disease in these animals. The effect
of agents which block the binding of AGEs to its receptor
will also be studied to investigate the interaction
between these two pathways. The genetic manipulations
to change the enzyme activity circumvent the use of
chemical inhibitors which may interact with unintended
target enzymes, and should contribute to the understanding
and management of diabetic kidney disease. |
| Project Title: | Impaired glucose tolerance
as a marker for cardiovascular risk |
| Investigator(s): | Prof.
Lam K.S.L., Prof. Lam T.H., Dr. Wat N.M.S. |
| Department: | Medicine |
| Source(s) of Funding: | Health
Care and Promotion Fund |
| Start Date: | April 2000 |
| Abstract: |
| To determine the conversion rate of IGT to
type 2 diabetes (NIDDM), as compared to normal subjects,
at 5 years using the WHO (1985 and 1998) and the ADA
(1997) diagnostic criteria; to ascertain the prevalence
and incidence of increased blood pressure as well as
its associations with other cardiovascular risk factors
at 5 years among IGT subjects as compared to normal
subjects. |
| Project Title: | Mutational analysis
and genotype-phenotype correlation in Chinese patients
with multiple endocrine neoplasia type 1 |
| Investigator(s): | Prof.
Lam K.S.L., Dr. Lam K.Y., Dr. Lo C.Y. |
| Department: | Medicine |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | November 2000 |
| Abstract: |
| To conduct germ line mutation analysis of the
MEN1 gene in 11 Chinese families with multiple endocrine
neoplasia type 1 (MEN1); to investigate the pathogenesis
of the MEN1 tumours by means of somatic mutation analysis
of the MEN1 gnee and loss of heterozygosity (LOH) studies;
to determine whether there is any genotype- phenotype
correlation in these MEN1 families. |
| Project Title: | Genetics of the metabolic
syndrome: central obesity |
| Investigator(s): | Prof.
Lam K.S.L., Dr. Wat N.M.S. |
| Department: | Medicine |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | November 2001 |
| Abstract: |
| To determine whether the above genetic variants
are associated with (a) central obesity (b) insulin
resistance and (c) other components of the Metabolic
Syndrome (obesity, impaired glucose tolerance, hypertension
or dyslipidaemia) in a cross-sectional study of 644
non-diabetic Southern Chinese; to investigate in a
5-year prospective study whether these genetic variants
are predictive of the cumulative incidence of type
2 diabetes or hypertension in this cohort. |
|
Cheung B.M.Y.,
Lo L.F., Lam T.H., Lam K.S.L.,
Lau C.P., Tam S.C.F., Wat N.M.S., Man Y.B. and Cheng
C.H., Follow up of the Hong Kong cardiovascular risk
factor prevalence survey cohort, J HK Coll Cardiol.
2002, 10 (Supple): 129.
|
|
Cheung B.M.Y.,
Lo L.F., Lam T.H., Lam K.S.L.,
Lau C.P., Tam S.C.F., Wat N.M.S., Man Y.B. and Cheng
C.H., Six year follow up of the Hong Kong cardiovascular
risk factor prevalence survey cohort, Cardiovascular
Drugs Therapeutics. 2002, 16(Supple 1): 26-27.
|
|
Cheung P.T.,
Chan K.W.,
Qong Z.Q., Kwan
E.Y.W., Tam S.C.F., But B., Lam
K.S.L., Chan
V.N.Y. and Low
L.C.K., Novel Mutations of ABCG5 and ABCG8 Genes
in 15 Chinese Sitosterolaemia Patients, Endo 2002,
84th Annual Meeting, Endocrine Society, San Franciso,
USA, 19-22 June 2002. 315.
|
|
Chow W.S., Tan
K.C.B., Tam
S.C.F., Ai V.H.G., Lam C.H.L. and Lam
K.S.L., Inflammation and endothelial dysfunction
in patients with type 2 diabetes mellitus, 2nd International
Huaxia Congress of Endocrinology. Hong Kong December,
2001. HK.
|
|
Chow W.S., Tan
K.C.B., Ai V.H.G. and Lam
K.S.L., Relationship of quantitative insulin
sensitivity check index and body fat mass and distribution
in type 2 diabetes, 5th International Diabetes Federation
Western Pacific Region Congress. Beijing, May 2002.
PRC.
|
|
Ip M.S.M.,
Lam B., Ng M.M.T.,
Lam W.K., Tsang K.W.T. and
Lam K.S.L.,
Hyperinsulinemia in obstructive sleep apnea, American
Thoracic Society International Conference, San Francisco,
USA, 2001. American Journal of Respiratory & Critical
Care Medicine. 2001, 163(5): A637.
|
|
Lam K.S.L.
and Tan K.C.B.,
Dyslipidaemia and endothelial dysfunction n type 2
diabetes, 5th International Diabetes Federation
Western Pacific Region Congress. Beijing, May 2002.
PRC.
|
|
Lam K.S.L.
and Tan K.C.B.,
RENAAL: angiotensin II receptor antagonist and nephropathy
in type 2 diabetes, The First World Heart Foundation
Global Conference on Cardiovascular Clinical Trials,
Hong Kong November 2001. HK.
|
|
Tan K.C.B.,
Chow W.S., Ai V.H.G., Metz C., Bucala R. and Lam K.S.L.,
Advanced glycation end products and endothelial dysfunction
in type 2 diabetes mellitus, Diabetes
Care. 2002, 25: 1055-1059 (A).
|
|
Tan K.C.B.,
Chow W.S., Tam
S.C.F., Ai V.H.G., Lam C.H.L. and Lam
K.S.L., Atorvastatin lowers C-reactive protein
and improves endothelial dysfunction in type 2 diabetes
mellitus, 2nd International Huaxia Congress of Endocrinology.
Hong Kong December, 2001. H.
|
|
Tan K.C.B.,
Tso A.W.K., Pang
R.W.C. and Lam
K.S.L., Effects of Sandostatin LAR on lipoprotein
metabolism in patients with acromegaly - a six-month
prospective study, The Endocrine Society 83rd Annual
meeting. Denver, June 2001. 2002.
|
|
Tan K.C.B.,
Chow W.S., Ai V.H.G. and Lam
K.S.L., Effects of angiotensin II receptor
antagonist on endothelial vasomotor function and urinary
albumin excretion in type 2 diabetic patients with
microalbuminuria, Diabetes/Metabolism Research and
Reviews. 2002, 18: 71-76.
|
|
Tan K.C.B.,
Chow W.S., Ai V.H.G. and Lam
K.S.L., Effects of losartan on urinary albumin
excretion and endothelial vasomotor function in type
2 diabetic patients with microalbuminuria, 37th
Annual Meeting of the European Association for the
Study of Diabetes. Glasgow, September 2001. UK,
2002.
|
|
Tan K.C.B.,
Chow W.S., Ai V.H.G., Metz C., Bucala R. and Lam K.S.L.,
Endothelial dysfunction and advanced glycation end
products in type 2 diabetes mellitus, 3rd Congress
of the Asia Pacific Society of Atherosclerosis and
Vascular Diseases. Cebu, February, 2002. Cebu.
|
|
Tan K.C.B.,
Chow W.S., O K.,
Ai V.H.G. and Lam
K.S.L., Hyperhomocysteinaemia and endothelial
dysfunction in patients with type 2 diabetes mellitus,
The 5th European Congress of Endocrinology. Turin,
Italy. June 2001. Turin, Italy, 2002, June 2001.
|
|
Wat N.M.S.,
Lam T.H., Janus
E.D. and Lam
K.S.L., Central obesity predicts the worsening
of glycemia in southern Chinese, International Journal
of Obesity. 2001, 25: 1789-93.
|
|
Xu J., Zhang
W., Chan V.N.Y.
and Lam K.S.L.,
Functional Analysis of Mutations in the Hepatocyte
Nuclear Factor-1 alpha Gene in Chinese MODY Families,
Sixth Research Postgraduate Symposium, September
26-28, 2001, The University of Hong Kong, Hong Kong.
2001.
|
|
Xu J., Zhang
W., Chan V.N.Y.
and Lam K.S.L.,
Mutations in the Hepatocyte Nuclear Factor-1 alpha
Gene in Chinese MODY Families: Prevalence and Functional
Analysis., Second International Huaxia Congress
of Endocrinology, December 14-17, 2001. Hong Kong.
|
| Project Title: | To measure the gastroduodenal
mucosal blood flow, nitric oxide and prostaglandin
content of the gastric mucosa at different phases of
healing of duodenal ulcer, before and after eradication
of Helicobacter pylori (HP) |
| Investigator(s): | Prof.
Lam S.K., Dr. Cho C.H., Dr. Hui W.M., Dr. Lau K.K. |
| Department: | Medicine |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | July 1996 |
| Abstract: |
| To measure the gastroduodenal mucosal blood
flow, nitrous oxide and prostaglandin content of the
gastric mucosa at different phases of healing of duodenal
ulcer, before and after eradication of Helicobacter
pylori (HP). |
| Project Title: | A study on the proliferative
activity and apoptosis in gastric epithelial cells
of helicobacter pylori (HP) infected patients on non-steroidal
anti-inflammatory drugs (NSAIDs) before and after treatment
with antibiotics and misoprostol |
| Investigator(s): | Prof.
Lam S.K., Dr. Hui W.M., Dr. Lam K.C., Dr. Yuen S.T. |
| Department: | Medicine |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | July 1997 |
| Abstract: |
| To study the mechanism of gastric epithelial
injury by HP infection and NSAIDs; to study the interaction
between HP infection and NSAIDs in gastric epithelial
injury; to study the changes in gastric epithelial
injury after HP eradication and administration of cytoprotective
agents. |
| Project Title: | Macrophage migration
inhibitory factor expression in chronic gastritis and
peptic ulcer in patients with helicobacter pylori infection |
| Investigator(s): | Prof.
Lam S.K., Dr. Lan H.Y., Dr. Wong B.C.Y. |
| Department: | Medicine |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | July 1999 |
| Abstract: |
| To identify the cell type(s) responsible for
constitutive MIF expression within the human stomach;
to examine the potential role of MIF expression in
the development of human gastritis and gastric ulcer. |
| Project Title: | Chemoprevention of
gastric cancer by treatment of Helicobacter pylori
infection |
| Investigator(s): | Prof.
Lam S.K., Dr. Ho J.C.Y., Dr. Lam K.C., Dr. Wong B.C.Y.,
Dr. Yuen S.T. |
| Department: | Medicine |
| Source(s) of Funding: | Hong
Kong Research Grants Council Competitive Earmarked
Research Grants |
| Start Date: | July 1999 |
| Completion Date: | June 2002 |
| Abstract: |
| To assess if the treatment of Helicobactor
pylori infection in asymtomatic individuals can reduce
the incidence of gastric cancer in a high risk area
over a five year period; to assess if the treatment
of Helicobactor pylori infection will lead to progression
or regression of various precancerous gastric conditions
including gastric atrophy, intestinal metaplasia and
dysplasia over a five year period; to assess the long
term sequelae of Helicobacter pylori eradication both
clinically, including development of gastroesophageal
reflux, and histologically, including changes in cell
proliferation and apoptosis. |
| Project Title: | Chemoprevention of
gastric cancer by intervention with Helicobacter pylori
and cyclooxygenase pathway |
| Investigator(s): | Prof.
Lam S.K., Dr. Wong B.C.Y., Prof. Xu G.W. |
| Department: | Medicine |
| Source(s) of Funding: | Hong
Kong Research Grants Council Competitive Earmarked
Research Grants |
| Start Date: | December 2001 |
| Abstract: |
| To assess if the combination of treatment of
Helicobacter pylori infection and use of specific cyclooxygenase-2
inhibitors in asymptomatic individuals can reduce the
incidence of gastric cancer in a high risk area over
a five to ten year period; to assess if the combination
of treatment of Helicobacter pylori infection and use
of specific cyclooxygenase-2 inhibitors will lead to
progression or regression of various precancerous gastric
conditions including gastric atrophy, intestinal metaplasia
and dysplasia over a three year period; to assess the
long term sequelae of Helicobacter pylori eradication
and use of specific cyclooxygenase-2 inhibitors histologically,
including changes in cell proliferation, apoptosis
and oncogene expressions. |
|
Chan A.O.O., Wong
B.C.Y. and Lam
S.K., Gastric cancer: past, present and future,
Can J Gastroenterol. 2001, 15(7): 469-474.
|
|
Fan X.M., Wong
B.C.Y., Zhou X.M., Wang W.P., Lin
M.C., Kung
H., Yuen S.T., Leung
S.Y. and Lam
S.K., Inhibition of proteasome function induced
apoptosis in gastric cancer cells, International
Journal of Cancer. 2001, 93(4): 481-8.
|
|
Fan X.M., Wong B.C.Y., Wang W.P., Zhou X.M., Cho
C.H., Yuen S.T., Leung S.Y., Lin M.C.M., Kung
H. and Lam
S.K., Inhibition of proteasome function induced
apoptosis in gastric cancer, International
Journal of Cancer. Wiley-Liss, Inc., 2001,
93: 481-488.
|
|
Fung F.M.Y.,
Wong W.M.,
Lam S.K.,
Yee Y.K., Hung W.K., Yip W.C., Szeto M.L., Tong
S.M., Lai K.C.,
Hu H.C., Hui
C.K. and Wong B.C.Y.,
Rabeprazole based 3-day and 7-day triple therapy vs
7-day omeprazole based triple therapy for the treatment
of Helicobacter pylori infection, Journal
of Gastroenterology and Hepatology. 2001, 16
(9 suppl): A127.
|
|
Fung P.C.W.
and Lam S.K.,
Diseases, Nitric Oxide and Related Potent Therapy,
Medical Progress. 2001, 19-22.
|
|
Gu Q., Wong
W.M., Lam
S.K., Yin Y., Wang W.H., Fung
F.M.Y., Lai
K.C., Xia H.H.X.,
Wong B.C.Y.
and Xiao S.D., One week omeprazole, furazolidone and
amoxycillin rescue therapy after failure of Helicobacter
pylori eradication with standard triple therapies,
Gastroenterology.
2002, 122 (4 suppl 1): A586.
|
|
Hu H.C., Wong Y.H., Lai K.C., Hui
W.M., Lam K.F.,
Wong B.C.Y.,
Xia H.H.X.,
Chan C.K.,
Wong W.M.,
Tsang K.W.T.
and Lam S.K.,
Normal 24-hour ambulatory proximal and distal gastroesophageal
reflux parameters in Chinese, Hong Kong Medical
Journal. Hong Kong, Hong Kong Academy of Medicine
and the Medical Association, 2002, 8: 168-171.
|
|
Hu H.C., Lam K.F., Wong
Y.H., Lam C.L.K.,
Hui W.M., Lai K.C., Wong
B.C.Y. and Lam
S.K., The Hong Kong index of dyspepsia: A validated
symptom severity questionnaire for patients with dyspepsia,
Journal
of Gastroenterology and Hepatology. Melbourne,
Australia, Blackwell Science, 2002, 17: 545-551.
|
|
Huang X.R., Chun Hui C.W., Chen Y.X., Wong
B.C.Y., Fung
P.C.W., Metz C., Cho
C.H., Hui W.M.,
Bucala R., Lam
S.K., Lan
H.Y., Chun B. and Wong Y., Macrophage migration
inhibitory factor is an important mediator in the pathoenesis
of gastric inflammation in rats, Gastroenterology.
2001, 121(3): 619-630.
|
|
Huang X.i.a.o. .R.u., Hui C.o.n.n.i.e. .W. .C., Chen
Y.o.n.g. .X.i.o.n.g., Wong
B.C.Y., Fung
P.C.W., Metz C.h.r.i.s.t.i.n.e., Cho C.h.i.n. .H.i.n.,
Hui W.a.i. .M.o., Bucala R.i.c.h.a.r.d., Lam
S.K. and Lan H.u.i. .Y., Macrophage Migration
Inhibitory Factor is an Important Mediator in the Pathogenesis
of Gastric Inflammation, Gastroenterology.
2002, 121: 619-630.
|
|
Jiang X., Lam S.K., Fan
X.M., Lin M.C.,
Kung H. and
Wong B.C.Y.,
Specific COX-2 inhibitor suppresses NF-kB activation
by inhibition of RelA/p65 nuclear translocation in
gastric cancer, Gastroenterology. 2002, 122(4
Suppl 1): A240.
|
|
Jiang X., Lam S.K., Tu S., Lin
M.C., Kung
H. and Wong
B.C.Y., Specific COX-2 inhibitor suppresses anchorage-independent
cell growth through AP-1/MAPK pathway in gastric cancer
(oral presentation), Gastroenterology. 2002,
122(4 Suppl 1).
|
|
Lai K.C., Cho C.H.,
Hui W.M., Hu H.C., Wong C.Y. and Lam
S.K., A Study on the Effect of COX-2 Inhibitors
on Gastric Mucosal Prostaglandin Synthesis, The
7th Medical Research Conference, 26-27 January, 2002.
24(2).
|
|
Lai K.C., Lam S.K., Chu K.M., Wong
B.C.Y., Hui
W.M., Hu H.C.,
Lau G., Wong W.M., Yuen M.F., Chan
A.O.O., Lai C.L.
and Wong J.,
Lansoprazole for the prevention of recurrences of ulcer
complications from long-term low-dose aspirin use,
New
England Journal of Medicine. 2002, 346(26):
2033-2038.
|
|
Lam S.K.
and Fung P.C.W.,
Diseases, nitric oxide and related potent therapy,
Medical Progress. 2002, 19-22.
|
|
Ng F.H., Wong W.M.,
Wong B.C.Y.,
Kng C., Wong S.Y., Lai
K.C., Cheng C.S., Yuen W.C., Lam
S.K. and Lai
C.L., Sequential intravenous/oral antibiotic vs.
continuous intravenous antibiotic in the treatment
of pyogenic liver abscess., Alimentary
Pharmacology and Therapeutics. 2002, 16(6):
1083-1September 0.
|
|
Wong B.C.Y.,
Jiang X.
and Lam S.K.,
Cyclooxygenase and gastric cancer, Journal of Modern
Digestion and Intervention. 2001, 6 (6): 23-25.
|
|
Wong B.C.Y.,
Yin Y., Berg D.E., Xia
H.H.X., Zhang J.Z., Wang W.H., Wong
B.C.Y., Huang X.R., Tang V.S. and Lam
S.K., Distribution of distinct vacA, cagA and
iceA alleles in Helicobacter pylori in Hong Kong, Helicobacter.
2001, 6(4): 317-324.
|
|
Wong B.C.Y.,
Wang W.P., So H.L.,
Shin V.Y.,
Wong W.M.,
Fung F.M.Y.,
Liu E.S.L.,
Hui W.M., Lam S.K. and
Cho C.H., Epidermal
growth factor and its receptor in chronic active gastritis
and gastroduodenal ulcer before and after Helicobacter
pylori eradication, Alimentary
Pharmacology and Therapeutics. 2001, 15(9):
1459-1465.
|
|
Wong B.C.Y.,
Lam S.K.,
Wong W.M.,
Zheng T., Chen
J.S., Chen B.W., Lai
K.C., Yuen
S.T. and Ho
J.C.Y., Eradicating Helicobacter pylori infection
in general population prevents gastric cancer: 1 7
year prospective randomized placebo-controlled study,
Gstroenterology.
2002, 122 (4 suppl 1): A588.
|
|
Wong B.C.Y.,
Lam S.K.,
Wong W.M.,
Feng R.E., Zheng
T., Yuen S.T.,
Ho J.C.Y., Leung S.Y., Chen
J.S. and Lai K.C.,
Eradication of Helicobacter pylori infection significantly
slows down the progression of precancerous lesions
in high risk population: a 5-year prospective randomized
study, Gastroenterology.
2002, 122 (4 suppl 1): A588.
|
|
Wong B.C.Y.,
Wong W.M.,
Yee Y.K., Hung W.K., Yip A.W., Seto M.L., Li K.F.,
Lau P., Fung F.M.Y.,
Tong S.M.,
Lai K.C., Hu H.C., Yuen
M.F., Hui C.K. and Lam
S.K., Rabeprazole-based 3-day and 7-day triple
therapy vs omeprazole-based 7-day triple therapy for
the treatment of Helicobacter pylori infection, Alimentary
Pharmacology and Therapeutics. 2001, 15(12):
1959-1965.
|
|
Wong B.C.Y.,
Jiang X.
and Lam S.K.,
Role of cyclooxygenase-2 and gastric cancer. (in Chinese),
Journal of Modern Digestion and Intervention.
2002, 7(5): 69-70.
|
|
Wong B.C.Y.,
Wang W.H., Wong W.M., Lau
G., Fung F.M.Y., Kung N.N.S., Chu
K.M., Lai K.C., Hu W.H.C., Hu F.L., Liu X.G., Chan
C.K., Yuen M.F., Hui
W.M. and Lam
S.K., Three-day Lansoprazole quadruple therapy
for Helicobacter pylori-positive duodenal ulcers: a
randomized controlled study, Alimentary
Pharmcology and Therapeutics. 2001, 15: 843-850.
|
|
Wong W.M.,
Wong B.C.Y.,
Xia H.H.X.,
Tang V.S., Lai
K.C., Hu H.C.,
Yuen M.F.,
Chan C.K. and
Lam S.K.,
An evaluation of a rapid urine test for the diagnosis
of Helicobacter pylori infection in the Chinese population,
Alimentary
Pharmacology and Therapeutics. 2002, 16(4):
813-817.
|
|
Wong W.M.,
Wong B.C.Y.,
Tang V.S.Y., Wong K.W., Li T.M., Cheung K.L., Fung
F.M.Y., Lai
K.C., Hu H.C.,
Chan C.K.,
Xia H.H.X.
and Lam S.K.,
Evaluation of three near patient tests for the diagnosis
of Helicobacter pylori infectino in Chinese population,
The
Hong Kong Practitioner. 2002, 24 (2 suppl):
43.
|
|
Wong W.M.,
Mandir N., Goodlad R.A., Wong
B.C.Y., Garcia S.B., Lam
S.K. and Wright A., Histogenesis of human colorectal
adenomas and hyperplastic polyps: the role of cell
proliferation and crypt fission, Gut.
2002, 50(2): 212-217.
|
|
Wong W.M.,
Wong B.C.Y.,
Lu H., Gu Q.,
Yin Y., Wang W.H., Fung
F.M.Y., Lai
K.C., Xia H.H.X.,
Xiao D. and Lam
S.K., One-week omeprazole, furazolidone and
amoxicillin rescue therapy after failure of Helicobacter
pylori eradication with standard triple therapies,
Alimentary
Pharmacology and Therapeutics. 2002, 16(4):
793-798.
|
|
Wong W.M.,
Gu Q., Lam S.K., Fung F.M.Y., Lai K.C., Xia
H.H.X., Hu
H.C. and Wong
B.C.Y., Randomized controlled trial of rabeprazole,
levofloxacin and rifabutin triple therapy versus rabeprazole-based
quadruple therapy as a rescue treatment for failure
of Helicobacter pylori eradication with standard tiple
therapies, Gastroenterology.
2002, 122 (4 suppl 1): A587.
|
|
Wong W.M.,
Lai K.C., Lau C.P., Hu
H.C., Chen
W.H., Wong
B.C.Y., Hui
W.M., Wong
Y.H., Xia H.H.X.
and Lam S.K.,
Upper gastrointestinal evaluation of Chinese Patients
with non-cardiac chest pain, Alimentary
Pharmacology and Therapeutics. 2002, 16(3):
465-471.
|
|
Wong W.M.,
Lai K.C., Lau C.P., Hu
H.C., Chen
W.H., Wong
B.C.Y., Hui
W.M., Wong
Y.H., Xia H.H.X.
and Lam S.K.,
Upper gastrointestinal evaluation of Chinese patients
with noncardiac chest pain, The
Hong Kong Practitioner. 2002, 24 (2 suppl):
44.
|
|
Xia H.H.X.,
Wong B.C.Y.,
Wong K.W., Wong S.Y., Wong
W.M., Lai K.C.,
Hu H.C., Chan C.K. and
Lam S.K.,
Clinical and endoscopic characteristics of non-Helicobacter
pylori, non-NSAID duodenal ulcers: a long-term prospective
study, Alimentary
Pharmacology and Therapeutics. 2001, 15(12):
1875-1882.
|
|
Xia H.H.X.,
Wong B.C.Y.,
Huang X.R., He X.X., Wong
W.M., Leung
S.Y., Yuen
S.T., Lan H.Y.
and Lam S.K.,
Expression of macrophage migration inhibitory factor
in Helicobacter pylori induced gastritis and peptic
ulcer disease, The
Hong Kong Practitioner. 2002, 24 (2 suppl):
41.
|
|
Xia H.H.X.,
Wong B.C.Y.
and Lam S.K.,
Helicobacter pylori infection and gastroduodenal muscosal
damage and healing, Gastrointestinal mucosal repair
and experimental therapeutics. Front Gastrointest
Res. Switzerland, S Karger AG, 2002, 143-157.
|
|
Xia H.H.X.,
Wong B.C.Y.,
Wong W.M.,
Tang V.S., Cheung H.K., Sham F.N., Fung
F.M.Y., Lai
K.C., Hu H.C.,
Chan C.K. and
Lam S.K.,
Optimal serological tests for the detection of Helicobacter
pylori infection in the Chinese population, Alimentary
Pharmacology and Therapeutics. 2002, 16(3):
521-526.
|
|
Zhang H.B., Wong
B.C.Y., Zhou X.M., Guo X.G., Zhao S.J., Wang J.H.,
Wu K.C., Ding J., Lam
S.K. and Fan D.M., Effects of somatostatin,
octreotide and pitressin plus nitofglycerine on systemic
and protal haemodynamics in the control of acute variceal
bleeding, International Journal of Clinical Practice.
2002, 56(6).
|
|
Wong B.C.Y.,
Gu Q. and Lam S.M.,
Diagnosis and treatment of Helicobacter pylori infection
in Hong Kong, Helicobacter pylori infection: basic
and clinical aspects. Chinese Science and Technology
Press, 2002, 449-455.
|
| Project Title: | Why do family doctors
prescribe antibiotics for upper respiratory tract infection? |
| Investigator(s): | Dr.
Lam T.P., Dr. Lam K.F. |
| Department: | Family
Medicine Unit of the Department of Medicine |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | November 2000 |
| Abstract: |
| To investigate the clinical factors which may
influence family physicians' decision to prescribe
antibiotics for upper respiratory tract infections
(URTI). |
| Project Title: | What are the effects
of the new medical curriculum on our students? |
| Investigator(s): | Dr.
Lam T.P., Prof. Chan Y.S., Dr. Cheng Y.H., Dr. Khoo
U.S. |
| Department: | Family
Medicine Unit of the Department of Medicine |
| Source(s) of Funding: | Run
Run Shaw Research and Teaching Endowment Fund |
| Start Date: | January2002 |
| Abstract: |
| To examine teachers' perceptions of final year
medical students before and after curriculum reform
at the University of Hong Kong. |
|
Clearihan L., Lam
T.P. and Leopando Z., Strengthening regional
ties and enhancing family medicine - the role of our
new journal, Asia Pacific Family Medicine. 2002,
1: 1-2.
|
|
Lam T.P.,
Awarded the Hong Kong College of Family Physicians
2001 Best Research Award for the paper "Chinese fishermen's
expectations on medications", 2001.
|
|
Lam T.P.,
Doctor of Philosophy, Faculty of Medicine, University
of Sydney. 1997-2002 Thesis title: "A study of the
effects of land migration on the health of water people
in Hong Kong and the implications for clinical practice",
2002.
|
|
Lam T.P.
and Lam K.F.,
Family doctors' attitudes towards patient self-management
of upper respiratory tract infections, Hong Kong
Medical Journal. Hong Kong, 2001, 7: 146-149.
|
|
Lam T.P.
and Lam K.F.,
Management of upper respiratory tract infection by
family doctors, International Journal of Clinical
Practice. Surrey, Esher, 2001, 55(6): 358-360.
|
|
Lam T.P.,
Medical writing and preparing your research for publication,
A workshop presentation together with Dr Lyn Clearihen
and Prof Zorayda Leopando at Wonca Asia Pacific Regional
Conference. April 2002.
|
|
Lam T.P.,
The global standard of family medicine training, 25th
Japanese Association of Primary Care Physicians, Kobe,
June 2002.
|
|
Lam T.P.,
The strengths and weaknesses of Traditional Chinese
Medicine and Western Medicine in the eyes of Chinese,
Journal of Epidemiology and Community Health.
2001, 55: 762-765.
|
|
Lam T.P.,
In: Co-Editor of Asia Pacific Family Medicine - the
Official Journal of Wonca Asia Pacific - launched in
2002, 2002.
|
|
Chan L.Y.,
Fong D., Lam C.L., Chan
M.M.W., Say J.T.K., Leung
Y.H., Zheng L., Ooi
C.G.C., Ip
M.S.M., Lam
W.K. and Tsang
K.W.T., Validation of the Hong Kong Chinese version
of St Georges' Respiratory Questionnaire, The Hong
Kong Practitioner. 2002, 23 Suppl 2: 30.
|
|
Choi K. and Lam
W.K., Management of community acquired pneumonia
in the immunocompetent adult, Hong Kong Medical
Association Continuing Medical Education Bulletion.
2001, 1-6.
|
|
Ho C.T.K., Li L.S.W. and Lam
W.K., Review of the effectiveness of a 4-week
intensive pulmonary rehabilitation program in COAD
patients, Medical Research Conference, University
Department of Medicine, Hong Kong, 2002. The Hong
Kong Practitioner. 2002, 24 (2): 53 (C-R-1).
|
|
Ho J.C.M., Lam C.L., Ip S., Wong
M.P., Lam
W.K. and Tsang
K.W.T., Exhaled nitric oxide predicts lung function
but not quality of life in subjects with non-small
cell lung cancer, Medical Research Conference, University
Department of Medicine, Hong Kong, 2002. The Hong
Kong Practitioner. 2002, 24 (2): 57 (C-RC-7).
|
|
Ho J.C.M., Chan K.N., Hu
H.C., Lam
W.K., Zheng L., Tipoe
G.L., Sun J.Z.,
Leung Y.H.
and Tsang K.W.T.,
The effect of aging on nasal mucociliary clearance,
beat frequency and ultrastructure of respiratory cilia,
American
Journal of Respiratory and Critical Care Medicine.
2001, 163: 983-988.
|
|
Ho J.C.M., Hu H.C.,
Lam W.K.,
Chu L.W., Zheng
L., Tipoe G.L.,
Ooi C.G.C.,
Sun J.Z., Leung Y.H., Ip M.S.M., Chan M.M.W. and
Tsang K.W.T.,
The effect of aging on nasal mucociliary clearance,
beat frequency and ultrastructure of respiratory cilia,
Medical Research Conference, University Department
of Medicine, Hong Kong, 2001. The Hong Kong Practitioner.
2001, 23 (suppl 2): 66 (S-RM-5).
|
|
Ip M.S.M.,
Lam B., Ng M.M.T.,
Lam W.K.,
Tsang K.W.T.
and Lam K.S.L.,
Hyperinsulinemia in obstructive sleep apnea, American
Thoracic Society International Conference, San Francisco,
USA, 2001. American Journal of Respiratory & Critical
Care Medicine. 2001, 163(5): A637.
|
|
Ip M.S.M.,
Lam B., Mok W.Y.W.,
Ip T.Y. and
Lam W.K.,
Prevalence of sleep disordered breathing in middle-aged
Chinese women in Hong Kong, American Thoracic Society
International Conference, San Francisco, USA, 2001.
American Journal of Respiratory & Critical Care Medicine.
2001, 163(5): A636.
|
|
Ip M.S.M.,
Tipoe G.L.,
Leung T.M.,
Zheng L., Shum D.K.Y.,
Tsang K.W.T.
and Lam W.K.,
Sputum sol in bronchiectasis stimulates IL-6 production
from bronchial epithelial cells, American Thoracic
Society International Conference, San Francisco, USA,
2001. American Journal of Respiratory & Critical Care
Medicine. 2001, 163(5): A467.
|
|
Lam B., Ooi C.G.C.,
Peh W., Lam W.K.
and Ip M.S.M.,
Do obstructive sleep apnea(OSA) subjects have smaller
upper airway?, Chest. 2001, 120(4)(Suppl): 303S.
|
|
Lam B., Ooi C.G.C.,
Sam K., Lam W.K.,
Tsang K.W.T.
and Ip M.S.M.,
Upper airway change after oral appliance in obstructive
sleep apnoea patients - difference exist in good and
poor responders, Medical Research Conference, University
Department of Medicine, Hong Kong, 2001. The Hong Kong
Practitioner. 2001, 23(suppl 2): 27 (G-RM-6).
|
|
Lam C.L., Lam
W.K., Ip
T.Y., Ooi C.G.C.,
Lam B., Ip S., Wang J., Ho J.C.M., Yan C., Chan
L.Y., Zheng L., Man
R.Y.K. and Tsang
K.W.T., Effects of herbal preparation, coriolus
versicolor Yun-Zhi, on non-small cell lung cancer (NSCLC),
Medical Research Conference, University Department
of Medicine, Hong Kong. 2001.
|
|
Lam C.L., Lam
W.K., Yip T.C., Ooi
C.G.C., Lam B., Ip S., Wang J., Ho J.C.M., Yan
C.P.K., Chan
L.Y., Zheng L., Man
R.Y.K. and Tsang
K.W.T., Effects of herbal preparation, corioulus
versicolor Yun-zhi, on non-small cell lung cancer (NSCLC),
Medical Research Conference, University Department
of Medicine, Hong Kong, 2001. The Hong Kong Practitioner.
2001, 23 (supp 2): 28 (G-RM-8).
|
|
Lam C.L., Lam
W.K., Ho J.C.M., Yan
C.P.K., Chan S., Lam B., Zheng L., Ooi
C.G.C. and Tsang
K.W.T., Effects of yun-zhi on non-small cell lung
cancer (NSCLC), American Journal of Respiratory
Critical Care Medicine. 2001, 163(5): A67.
|
|
Lam C.L., Lam
W.K., Wong
M.P., Chung L.P., Ip
M.S.M., Tsang
K.W.T., Chau W.S., Suen W.S. and Chiu S.W., Establishment
and application of primary lung cancer cell lines (The
HKULC Series) with local Chinese characteristics in
Hong Kong, Joint Annual Scientific Meeting, Hong
Kong Thoracic Society, Chinese Thoracic Society and
American College of Chest Physicians, Hong Kong. 2002.
Abstract pp.26.
|
|
Lam C.L., Lam
W.K., Wong
M.P., Chung L.P., Chiu S.W. and Chau W.S., Establishment
of HKU lung cancer lines in Hong Kong - an ongoing
conjoint effort and progress report, Medical Research
Conference, University Department of Medicine, Hong
Kong, 2002. The Hong Kong Practitioner. 2002,
24 (2): 55 (C-RC-2).
|
|
Lam C.L., Lam
W.K., Wong
M.P., Chung L.P., Chiu S.W., Chau W.S. and Ho K.K.,
Promotor hypermethylation of the CpG Islands of human
Ras Association Domain Family 1A gene (RASSF1A) in
adenocarcinoma of lung in Hong Kong Chinese - a comparison
between smokers and non-smokers, Medical Research
Conference, University Department of Medicine, Hong
Kong, 2002. The Hong Kong Practitioner. 2002,
24 (2): 54 (C-RC-1).
|
|
Lam C.L., Lam
W.K., Ip
M.S.M., Tsang
K.W.T., Lam B., Yan
C.P.K., Ho J.C.M., Ip S. and Wong M.K.Y., The combined
use of gemcitabine and ifosfamide in patients with
Stage III or IV non-small cell lung cancer (NSCLC),
Medical Research Conference, University Department
of Medicine, Hong Kong, 2002. The Hong Kong Practitioner.
2002, 24(2): 55 (C-RC-3).
|
|
Lam C.L., Lam
W.K., Ip
M.S.M., Tsang
K.W.T., Lam B., Ho J.C.M., Ip S. and Wang J.K.L.,
The use of gemcitabine and cisplatin in Chinese patients
with advanced non-small cell lung carcinoma (NSCLC),
Medical Research Conference, University Department
of Medicne, Hong Kong, 2001. The Hong Kong Practitoner.
2001, 23(suppl 2): 24(G-RM-1).
|
|
Lam W.K.,
Acute exacerbation of COPD : predictive factors, treatment
and outcome, 3rd International Meeting on Respiratory
Care (RESPINA), Jakarta, Indonesia. 2001, T4-4:
67.
|
|
Lam W.K.,
Air pollution and the lung, International Symposium,
Japanese Respiratory Society, 41st Annual Scientific
Meeting, Tokyo, Japan 2001. 2001.
|
|
Lam W.K.,
Clinical and therapeutic significance of inflammation
and airway recmodlling in COPD, 3rd International
Meeting on Respiratory Care (RESPINA), Jakarta, Indonesia.
2001, T4-1: 64.
|
|
Lam W.K.,
Infections of the respiratory tract. McGraw Hill Book
Co., Australia Pty Ltd., Australia, Sydney, In: Ratnaike
RN, Practical Guide to Geriatric Medicine. 2002,
Chapter 50: 719-733.
|
|
Lam W.K.,
Introduction, Chemotherapy : Advanced strategies
for evaluation & medical management of lowr respiratory
tract infection. 2001, 47 (suppl 4): 1-2.
|
|
Lam W.K.,
Lung cancer - State of the Art, 4th Biennial Symposium,
Philippine Foundation for Lung Health Research & Development,
Manila, Philippines, 2001. 2001.
|
|
Lam W.K.,
Molecular epidemiology of lung cancer in Chinese :
Hong Kong experience, International Symposium on
Lung Cancer, National Taiwan University College of
Medicine, Taipei, Taiwan, 2001. 2001.
|
|
Lam W.K.,
Recent advances in the treatment and prophylaxis of
influenza, Clinical Pulmonary Medicine. 2002,
9: 145-149.
|
|
Lam W.K.,
Summary, Chemotherapy : Advanced strategies for
evaluation & medical management of lower respiratory
tract infection. 2001, 47 (suppl 4): 55-56.
|
|
Man C., Lam W.K.,
Liang R.H.S.
and Kwong Y.L.,
Genetic imbalances in lung cancer in Hong Kong by comparative
genomic hybridization, Chest. 2001, 120(4)(suppl):
317S.
|
|
Man C.W.Y.,
Lam W.K.,
Liang R.H.S.
and Kwong Y.L.,
Genetic imbalances in lung cancer in Hong Kong by comparative
genomic hybridisation., Annual International Conference
of American College of Chest Physicians. Philadelphia,
USA,. 2001.
|
|
Ooi C.G.C.,
Khong P.L.,
Ho I.W.T., Cheung F.T.F., Ip
M.S.M., Lam
W.K. and Ngan H., A CT quantiative morphometric-functional
correlative study of silicosis, European Congress
of Radiology, Vienna, Austria, 1-5 March 2002.
|
|
Ooi C.G.C.,
Ho JCM , Khong P.L., Lam
W.K. and Tsang
K.W.T., CT features of advanced primary pulmonary
lymphoepithelioma-like carcinoma (LELC), UK Radiological
Congress, Birmingham, UK, 2002.. 2002, 481.
|
|
Ooi C.G.C.,
Chan P.K., Lee J.C., Fok C.Y., Ho J.C.M., Lam B., Lam W.K. and
Tsang K.W.T.,
HRCT quantification of bronchiectasis : a functional-morphologic
study, Medical Research Conference, University Department
of Medicine, Hong Kong, 2001.The Hong Kong Practitioner.
2001, 23 (suppl 2): 28 (G-RM-9).
|
|
Ooi C.G.C.,
Chan P.K., Lee J.C., Fok C.Y., Lam
W.K. and Tsang
K.W.T., High resolution computed tomography quantification
of bronchiectasis with functional-morphologic correlation,
American Journal of Respiratory Critical Care Medicine.
2001, 163(5): A85.
|
|
Ooi C.G.C.,
Tan B.B.S., Tsang C.P., Lee I.Y.C., Leung K., Khong
P.L., Tsang
K.W.T. and Lam
W.K., Lymph node density in silicosis: its
relationship with lung function and clinical parameters.,
The Hong Kong Practitioner. 2002, 24(2): 56.
|
|
Ooi C.G.C.,
Cheng R.S., Lam V.S., Fok C.Y., Ngan
H.Y.S., Lam
W.K. and Tsang
K.W.T., Mediastinal nodal calcification pattern
on computed tomography in silicosis, American Journal
of Respiratory Critical Care Medicine. 2001, 163(5):
A168.
|
|
Ooi C.G.C.,
Kwong D.L.W.,
Ho J.C.M., Lock D.T., Chan
F.L., Lam
W.K., Ngan
H.Y.S., Au
G.K.H. and Tsang
K.W.T., Pulmonary sequalae of treatment for breast
cancer : a perspective study, International
Journal of Radiation Oncology, Biology, Physics.
2001, 50: 411-419.
|
|
Ooi C.G.C.,
Khong P.L.,
Chan-Yeung M., Ho J.C.M., Lam
W.K. and Tsang
K.W.T., The utility of HRCT in bronchiectasis:
a clinico-functional correlative study, European
Congress of Radiology, Vienna, Austria, 1-5 March 2002.
|
|
Shum H.Y.I.,
Zheng L., Taylor G., Lam
W.K., Fung
P.C.W., Leung
Y.H., Sun J.Z.,
Tipoe G.L.
and Tsang K.W.T.,
Pseudomonas aeruginosa 1-hycroxyphenazine stimulates
iNOS expression in human respiratory mucosa, American
Journal of Respiratory and Critical Care Medicine.
2001, 163(5): A670.
|
|
Shum H.Y.I.,
Zheng L., Taylor G., Sun
J.Z., Tipoe
G.L., Ho J.C.M., Fung
P.C.W., Lam
W.K. and Tsang
K.W.T., Upregulation of iNOS expression in human
respiratory mucosa by Pseudomonas aeruginosa 1-hydroxyphenazine,
The Hong Kong Practitioner. 2001, 23(Suppl 2):
66.
|
|
Tsang K.W.T.,
Chan S., Leung R , Tan
K.C.B., Chan
H.H.L., Ho
J.C.S., Yan C., Ooi
C.G.C., Fung P.C. and Lam
W.K., Anti-inflammatory treatment increased
exhaled nitric oxide production on patients with active
bronchiectasis., The Hong Kong Practitioner.
2002, 24(2): 59.
|
|
Tsang K.W.T.,
Leung J.C., Tipoe
G.L., Leung R., Yan C., Ooi
C.G.C., Chan
H.H.L., Fung
P.C.W., Lam
W.K. and Lai
K.N., Aquaporin 3 expression in respiratory mucosa
is down-regulated in bronchiectasis in vivo., The
Hong Kong Practitioner. 2002, 24(2): 58.
|
|
Tsang K.W.T.,
Leung J.C., Tipoe
G.L., Leung R., Yan C., Ooi
C.G.C., Chan
H.H.L., Fung
P.C.W., Lam
W.K. and Lai
K.N., Aquaporin 3 expression in respiratory mucosa
is down-regulated in bronchiectasis in vivo, The
Hong Kong Practitioner. 2002, 24: C-RC-8.
|
|
Tsang K.W.T.,
Kinoshita R., Rouke N., Yuen q., Hu
H.C. and Lam
W.K., Bronchoscopy of cetaceans, Journal
of Wildlife Diseases. 2002, 38(1): 224-227.
|
|
Tsang K.W.T.,
Lam C.L., Ho J.C.M., Lam B., Chan
L.Y., Man R.Y.K.,
Sham J.S.T.
and Lam W.K.,
Coriolus versicolor Yun-Zhi could delay deterioration
of patients with advanced non-small cell lung cancer,
The Hong Kong Practitioner. 2002, 24(2) Suppl:
59.
|
|
Tsang K.W.T.,
Ip S.K., Leung R., Tipoe G.L., Chan S.L., Shum I.H.,
Ip M.S.M.,
Yan C., Fung P.C., Chan
M.M.W. and Lam
W.K., Enhaled nitric oxide: the effects of
age, gender and body size, Lung.
2001, 179(2): 83-91.
|
|
Tsang K.W.T.,
Lam B., Ooi C.G.C.,
Ho J.C.S.,
Chan S., Yan C., Leung R., Ip
M.S.M., Chan
M.M.W. and Lam
W.K., Inhaled fluticasone therapy reduces exacerbation
frequency and sputum production in bronchiectasis (BX).,
The Hong Kong Practitioner. 2002, 24(2): 58.
|
|
Wang J.K.L., Lam
W.K., Ho J.C.M., Ip
M.S.M. and Tsang
K.W.T., Paclitaxel and carboplatin in advanced
non-small cell lung cancer (NSCLC), Hong Kong experience,
Medical Research Conference, University Department
of Medicine, Hong Kong, 2001. The Hong Kong Practitioner.
2001, 23(suppl 2): 25 (G-RM-3).
|
|
Wong M., Chan S., Yan C., Chan
M.M.W., Ho
J.C.S., Lam B., Ooi
C.G.C., Ip
M.S.M., Lam
W.K. and Tsang
K.W.T., Inhaled steroid therapy is associated with
improvement in quality of life among bronchiectasis
patients., The Hong Kong Practitioner. 2002,
24(2): 60.
|
|
Wong M.P.,
Chung P.L., Lam
W.K., Chiu S.W. and Fu K.H., Allelic imbalance
in chromosomes 3, 9 and 17 in lung cancers of non-smokers
in Hong Kong, Proceedings of the American Association
for Cancer Research. 2001, 42: 633(#3404).
|
|
Wong M.P.,
Chung L.P., Lam
W.K., Chiu S.W. and Fu K.H., Allelic imbalance
in lung cancers of non-smokers in Hong Kong, Oncogenomics
Conference of the American Association for Cancer Research,
Tucson, USA. 2001, Proceedings 2001: 48.
|
|
Zheng L., Lam
W.K., Shum
H.Y.I., Tipoe
G.L., Yan C.P.K.,
Leung Y.H.,
Sun J.Z., Ooi C.G.C., Ip M.S.M. and
Tsang K.W.T.,
Expression of matric matelloproteinase-8 and 9 is raised
in the airways of patients with bronchiectasis in vivo,
The Hong Kong Practitioner. 2001, 23(Suppl 2):
64.
|
|
Zheng L., Lam
W.K., Shum
H.Y.I., Tipoe
G.L., Yan C.P.K.,
Leung Y.H.,
Sun J.Z., Ooi C.G.C., Ip M.S.M. and
Tsang K.W.T.,
Over expression of matrix metalloproteinase-8 (MMP-8)
and -9 (MMP-9) in bronchiectatic airways in vivo, Medical
Research Conference, University Department of Medicine,
Hong Kong, 2001. The Hong Kong Practitioner. 2001,
23 (suppl 2): 64 (S-RM-1).
|
|
Zheng L., Lam
W.K., Tipoe
G.L., Shum
H.Y.I., Yan
C.P.K., Leung
Y.H., Sun J.Z.,
Ooi C.G.C.
and Tsang K.W.T.,
Overexpression of matrix metalloporteinase-8 and -9
in bronchiectatic airways in vivo, European Respiratory
Journal. 2002, 20: 170-176.
|
|
Zheng L., Shum
H.Y.I., Lam
W.K., Tipoe
G.L., Yan C.P.K.,
Ooi C.G.C.,
Ho J.C.M., Fung
P.C.W., Ip
M.S.M. and Tsang
K.W.T., Overexpression of matrix metalloproteinase-8
(MMP-8) and-9 in bronchiectatic airways in vivo, American
Journal of Respiratiry and Critical Care Medicine.
2001, 163(5): A671.
|
|
Yu C.M., Chau M.C., Sanderson
J.E., Fan Y.Y.,
Tang M.O.,
Fung W.H., Lin
H., Kong S.L.,
Lam Y.M.,
Hill M.R. and Lau
C.P., Tissue Doppler echocardiographic evidence
of reverse remodeling and improved synchronicity by
simultaneously delaying regional contraction after
biventricular pacing therapy in heart failure., In:
, Circulation. 2002, 105: 438-45.
|
|
Huang X.R., Chun Hui C.W., Chen Y.X., Wong
B.C.Y., Fung
P.C.W., Metz C., Cho
C.H., Hui W.M.,
Bucala R., Lam S.K.,
Lan H.Y.,
Chun B. and Wong Y., Macrophage migration inhibitory
factor is an important mediator in the pathoenesis
of gastric inflammation in rats, Gastroenterology.
2001, 121(3): 619-630.
|
|
Leung J.C.K.,
Lan H.Y.,
Tang C.S.O.,
Chan D.T.M.
and Lai K.N.,
Polymeric IgA up-regulates macrophage migration inhibitory
factor (MIF) in human mesangial cell. [Abstract presented
at the Annual Meeting of the American Society of Nephrology,
Oct 10-17, 2001, San Francisco, USA], Journal of
the American Society of Nephrology. 2001, 12: 112A-113A.
|
|
Xia H.H.X.,
Wong B.C.Y.,
Huang X.R., He X.X., Wong
W.M., Leung
S.Y., Yuen
S.T., Lan
H.Y. and Lam
S.K., Expression of macrophage migration inhibitory
factor in Helicobacter pylori induced gastritis and
peptic ulcer disease, The
Hong Kong Practitioner. 2002, 24 (2 suppl):
41.
|
|
Yu C.M., Lau C.P., Lai
K.W., Huang X.R., Chen
W.H. and Lan
H.Y., Elevation of plasma level of macrophage
migration inhibitory factor in patients with acute
myocardial infarction., Am J Cardiol. 2001,
88: 774-7.
|
|
Lau A.K.L.,
Chang C.H., Tai J.W.M., Eremenco S., Liang
R.H.S., Lie
A.K.W., Fong
D.Y.T. and Lau
C.M., Quality of life - Translation and validation
of the Functional Assessment of Cancer Therapy-Bone
Marrow Transplant (FACT-BMT) Version 4 quality of life
instrument into traditional Chinese, Bone Marrow
Transplantation. London, U.K., Macmillan Publishers
Ltd, 2002, 29: 41-49.
|
| Project Title: | Roles of macrophage
migration inhibitory factor (MIF) in acute myocardial
infarction |
| Investigator(s): | Prof.
Lau C.P., Dr. Lan H.Y., Dr. Yu C.M. |
| Department: | Medicine |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | November 2000 |
| Abstract: |
| To investigate the pathogenic role and mechanism
of macrophage migration inhibitory factor (MIF) after
myocardial infarction (AMI). |
| Project Title: | Role of nitric oxide
synthase and cyclooxygenase2 in angiogenesis after
acute myocardial infarction - therapeutic implication
by L-arginine |
| Investigator(s): | Prof.
Lau C.P., Dr. Ho D.S.W., Mr. Lai K.W.H., Dr. Tipoe
G.L., Dr. Tse H.F., Dr. Yu C.M. |
| Department: | Medicine |
| Source(s) of Funding: | Hong
Kong Research Grants Council Competitive Earmarked
Research Grants |
| Start Date: | December 2000 |
| Abstract: |
| Acute myocardial infarction (AMI) is the second
commonest killer worldwide. The present study is to
investigate the role of two cellular and molecular
pathways that hypothesized to play a major role in
angiogenesis in the heart muscles after AMI, namely
the production of nitric oxide (NO) by its key enzyme
nitric oxide synthase (NOS) and the synthesis of prostanoids
by cyclooxygenase (COX). |
| Project Title: | Role of alteration
of sodium current in human arial fibrillation |
| Investigator(s): | Prof.
Lau C.P., Dr. Chiu C.S.W., Dr. Li G.R. |
| Department: | Medicine |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | November 2001 |
| Abstract: |
| To study how the alteration of transmembrane
sodium current contributes to the slowed cardiac conduction
in patients with atrial fibrillation. |
|
Barold S.S., Israel C.W., Stroobandt R.X., Lau
C.P. and Gallardo I., Diagnosis of supraventricular
tachyarrhythmias by automatic mode switching algorithms
of dual chamber pacemakers, In: Ovsyshcher IE, New
developments in Cardiac Pacing and Electrophysiology.
Armonk, NY, Futura Publishing Co Inc, 2002, 123-136.
|
|
Chau J., Cheung
B.M.Y., McGhee
S.M., Lauder
I.J., Lau
C.P. and Kumana
C.R., The CARE study applied to Hong Kong patients
- a cost-benefit analysis, 7th Scientific Meeting
of the Hong Kong Pharmacology Society in Association
with the Zhejiang Pharmacological Society, Hong Kong
2001.
|
|
Cheung B.M.Y.,
Ho G.Y.Y., Ng P.P.Y., McGhee
S.M., Kumana
C.R. and Lau
C.P., Change in ambulatory blood pressure in
hypertensive patients is related to sodium intake,
2nd Congress of Asian-Pacific Society of Hypertension,
Pattaya 2001.
|
|
Cheung B.M.Y.,
Chow V., O K.
and Lau C.P.,
Elevated plasma homocysteine is associated with ischaemic
heart disease is Hong Kong Chinese, 3rd Meeting
of the Federation of the European Pharmacological Societies,
Lyons 2001.
|
|
Cheung B.M.Y.,
Lo L.F., Lam T.H., Lam
K.S.L., Lau
C.P., Tam
S.C.F., Wat
N.M.S., Man
Y.B. and Cheng C.H., Follow up of the Hong Kong
cardiovascular risk factor prevalence survey cohort,
J HK Coll Cardiol. 2002, 10 (Supple): 129.
|
|
Cheung B.M.Y.,
Law C.Y., O K.,
Man R.Y.K.
and Lau C.P.,
Homocysteine Levels are Elevated in Patients with Ischaemic
Heart Disease and Hypertension in Hong Kong , The
10th Annual Scientific Congress, 21-23 June, 2002.
9.
|
|
Cheung B.M.Y.,
Law C.Y., O K.,
Man R.Y.K.
and Lau C.P.,
Increased Homocysteine Levels in Patients with Ischaemic
Heart Disease and Hypertension, The 7th Medical
Research Conference dd 26 January 2002. 26.
|
|
Cheung B.M.Y.,
Law C.Y., Tam S.C.F., Kumana C.R. and
Lau C.P.,
Plasma renin and aldosterone in patients with essential
hypertension, 7th Scientific Meeting of the Hong
Kong Pharmacology Society in Association with the Zhejiang
Pharmacological Society, Hong Kong 2001.
|
|
Cheung B.M.Y.,
Lo L.F., Lam T.H., Lam
K.S.L., Lau
C.P., Tam
S.C.F., Wat
N.M.S., Man
Y.B. and Cheng C.H., Six year follow up of the
Hong Kong cardiovascular risk factor prevalence survey
cohort, Cardiovascular Drugs Therapeutics. 2002,
16(Supple 1): 26-27.
|
|
Cheung B.M.Y.,
Lam T.C., Law C.Y.,
Kumana C.R.
and Lau C.P.,
The relationship between blood pressure and obesity
in Hong Kong Chinese, 2nd Congress of Asian-Pacific
Society of Hypertension, Pattaya 2001.
|
|
Fan Y.Y., Lee K.L.F., Chow
W.H., Chau E. and Lau
C.P., Internal cardioversion of chronic atrial
fibrillation during percutaneous mitral commissurotomy:
insight into reversal of chronic stretch-induced atrial
remodeling., Circulation. 2002, 105: 2746-2752.
|
|
Lam T.C., Cheung
B.M.Y., Chung
S.S.M. and Lau
C.P., Age is a strong cardiovascular risk factor
in hypertensive patients, Hong Kong College of Cardiology.
2001, 9(Supple): 118.
|
|
Lam T.C., Cheung
B.M.Y., Chung
S.S.M. and Lau
C.P., Age is associated with high cardiovascular
risk in hypertensive patients, 7th Scientific Meeting
of the Hong Kong Pharmacology Society in Association
with the Zhejiang Pharmacological Society, Hong Kong
2001.
|
|
Lam T.C., Cheung
B.M.Y., Chung
S.S.M. and Lau
C.P., Age is the strongest predictor of systolic
blood pressure in hypertensive patients, 6th Research
Postgraduate Symposium of the University of Hong Kong
2001.
|
|
Lam T.C., Cheung
B.M.Y., Chung
S.S.M. and Lau
C.P., Aging is associated with high cardiovascular
risk in hypertensive patients, 9th International
Symposium of the Pacific Rim Association for Clinical
Pharmacogenetics, Hong Kong 2001.
|
|
Lau C.P.,
Tse H.F., Ng
W., Chan K.K., Li S.K., Keung K.K., Lau Y.K., Chen
W.H., Tang Y.W. and Leung S.K., Comparison of perindopril
versus captopril for treatment of acute myocardial
infarction., Am J Cardiol. 2002, 89: 150-154.
|
|
Lau C.P.,
Tse H.F., Yu C.M., Teo W.S.,
Kam R., Ng K.S., Huang S.S., Lin J.L., Fitts S.M.,
Hettrick D.A. and Hill M.R., Dual-site atrial pacing
for atrial fibrillation in patients without bradycardia.,
Am J Cardiol. 2001, 88: 371-5.
|
|
Lau C.P.
and Tse H.F.,
Early reinitiation of atrial fibrillation after electrical
defibrillation: a new electrphysiological phenomenon.,
Pacing and Clinical Electrophysiology. 2001,
24: 1581-1584.
|
|
Lee K.L.F.
and Lau C.P.,
Should all implantable cardioverter defibrillators
for ventricular arrhythmias be dual-chamber devices?,
Curr Cardiol Rep.. 2001, 3: 447-50.
|
|
Tse E.Y.Y.,
Lee K.L.F.
and Lau C.P.,
Adenosine triphosphate enhanced contrast pulmonary
venogram to facilitate pulmonary vein ablation., J
Cardiovasc Electrophysiol. 2002, 13: 300.
|
|
Tse H.F. and
Lau C.P.,
Advance in internal and external cardioversion., In:
Israel CW, Barold SS, Advances in the Treatment
of Atrial Tachyarrhythmias: Pacing, Cardioversion,
and Defibillation. Armonk, NY, Futura Publising
Co Inc, 2002, 419-435.
|
|
Tse H.F., Wang
Q., Yu C.M.,
Ayers G. and Lau
C.P., Effect of verapamil on prevention of
atrial fibrillation in patients implanted with an implantable
atrial defibrillator, Clin. Cardiol. 2001, 24(7):
503-505.
|
|
Tse H.F., Lau C.P.,
Rodriguez L.M., Timmermans C., Daoud E.G., Ayers G.M.
and Wellens H.J., Effects of coexisting cardiovascular
disease on the long-term efficacy and safety of the
implantable atrial defibrillator, Pacing Clin Electrophysiol.
2002, 25: 8September -15.
|
|
Tse H.F., Lee K.L.F., Fan Y.Y. and Lau C.P.,
Nonfluoroscopic magnetic electroanatomic mapping to
facilitate focal pulmonary viens ablation for paroxysmal
atrial fibrillation., Pacing Clin Electrophysiol.
2002, 25: 57-61.
|
|
Wong W.M.,
Lai K.C., Lau C.P.,
Hu H.C., Chen W.H., Wong B.C.Y., Hui W.M., Wong
Y.H., Xia H.H.X.
and Lam S.K.,
Upper gastrointestinal evaluation of Chinese Patients
with non-cardiac chest pain, Alimentary
Pharmacology and Therapeutics. 2002, 16(3):
465-471.
|
|
Wong W.M., Lai K.C., Lau
C.P., Hu W.H., Chen
W.H., Wong B.C., Hui W.M., Wong Y.H., Xia H.H.
and Leung S.K., Upper gastrointestinal evaluation of
Chinese patients with non-cardiac chest pain., Aliment
Pharmacol Ther.. 2002, 16: 465-71.
|
|
Wong W.M.,
Lai K.C., Lau C.P.,
Hu H.C., Chen W.H., Wong B.C.Y., Hui W.M., Wong
Y.H., Xia H.H.X.
and Lam S.K.,
Upper gastrointestinal evaluation of Chinese patients
with noncardiac chest pain, The
Hong Kong Practitioner. 2002, 24 (2 suppl):
44.
|
|
Xu W.,
Tse H.F., Chan F.H.Y., Fung P.C.W., Lee K.L.F. and
Lau C.P.,
New Bayesian discriminator for detection of atrial
tachyarrhythmias, Circulation
(Journal of the American Heart Association). Philadelphia,
USA, LWW, 2002, 105 (Issue 12): 1472-1479.
|
|
Yu C.M., Tipoe
G.L., Lai K.W.H. and Lau
C.P., Effects of combination of angiotensin-converting
enzyme inhibitor and angiotensin receptor antagonist
on inflammatory cellular infiltration and myocardial
interstitial fibrosis after acute myocardial infarction.,
J Am Coll Cardiol. 2001, 38: 1207-15.
|
|
Yu C.M., Lau C.P.,
Lai K.W., Huang X.R., Chen
W.H. and Lan
H.Y., Elevation of plasma level of macrophage migration
inhibitory factor in patients with acute myocardial
infarction., Am J Cardiol. 2001, 88: 774-7.
|
|
Yu C.M., Cheung B.M.Y.,
Leung R., Wang Q., Lai W.H. and Lau
C.P., Increase in plasma adrenomedulin in patients
with heart failure characterised by diastolic dysfunction.,
Heart. 2001, 86(2): 155-160.
|
|
Yu C.M. and
Lau C.P.,
Left ventricular reverse remodeling after biventricular
pacing in heart failure, In: Ovsyshcher IE, New
Developments in Cardiac Pacing and Electrophysiology.
Armonk, NY, Futura Publishing Co Inc, 2002, 221-227.
|
|
Yu C.M., Chau M.C., Sanderson
J.E., Fan Y.Y.,
Tang M.O.,
Fung W.H., Lin
H., Kong S.L.,
Lam Y.M., Hill
M.R. and Lau
C.P., Tissue Doppler echocardiographic evidence
of reverse remodeling and improved synchronicity by
simultaneously delaying regional contraction after
biventricular pacing therapy in heart failure., In:
, Circulation. 2002, 105: 438-45.
|
|
Yu C.M., Tse H.F., Chau
M.C., Fan Y.Y.,
Lee K.L.F.,
Leung S.K., Wan S.H. and Lau
C.P., 雙心室起搏治療心力衰竭的初步經驗, In: , 中華心律失常學雜誌, 2002,
4.
|
|
Au W.Y., Luo
X., Liang R.H.S.
and Lau G.,
Hepatitis B virus reactivation after cytotoxic or immunosuppresive
therapy, pathogenesis and management, Rev Med Virol.
2001, 5: 287-299.
|
|
Lai K.C., Lam S.K., Chu
K.M., Wong
B.C.Y., Hui
W.M., Hu H.C.,
Lau G.,
Wong W.M.,
Yuen M.F.,
Chan A.O.O., Lai
C.L. and Wong
J., Lansoprazole for the prevention of recurrences
of ulcer complications from long-term low-dose aspirin
use, New
England Journal of Medicine. 2002, 346(26):
2033-2038.
|
|
Lau G.,
Ngan R., He M.L., Cheung M.C., Yiu H.Y., Cheng H.C.,
Lie A.K.W.,
Kung K.F. and Liang
R.H.S., A randomised study of lamivudine for prevention
of HBV reactivation in HbsAg seropositive patients
undergoing cytotoxic chemotherapy., Annual Meeting
of the American Association for study of Liver Diseases..
2002.
|
|
Lau G.,
Suri D., Liang
R.H.S., Rigoponlon E.I., Thomas M.G., Mullerova
, Yuen S.T.,
Williams R. and Naoumov N.V., Adoptive transfer of
immunity to hepatitis B virus nucleocapsid protein
terminates chronic HBV infection., Gastroenterology.
2002, 122: 614-624.
|
|
Lau G.,
Leung A.Y.H.,
Au W.Y., Kwong Y.L., Lie A.K.W., Liang R.H.S.,
Hou J., Nanji A.A.
and Fong D.Y.T.,
High HBV DNA viral load is the most significant risk
factor for hepatitis B reactiation in hepatitis B surface
antign positive patients treated with autologous hematopoietic
stem cell transplantation, Blood.
2002, 99: 2324-2330.
|
|
Lau G.,
Au W.Y., Lie A.K.W., Fong
D.Y.T., Kwong Y.L.
and Liang R.H.S.,
Reduction of hepatitis due to HBV reactivation in HbsAg
positive patients undergoing allogeneic bone marrow
transplantation with pre-emptive lamuvidine treatment.,
52th Annual Meeting of American Association for
study of Liver disease.. 2001.
|
|
Lau G.,
Suri D., Liang
R.H.S., Rigopoulou E.I., Thomas M.G., Mullerova
I., Nanji A.A.,
Yuen S.T.,
Williams R. and Naoumov N.V., Resolution of chronic
hepatitis B and anti-HBs seroconversion in humans by
adoptive transfer of immunity to hepatitis B core antigen,
Gastroenterology.
2002, 122(3): 614-624.
|
|
Lo C.M., Fan S.T., Liu
C.L., Yong B.H., Lai
C.L., Lau
G., Wei
W.I., Tam P.K.H.,
Tsoi N.S., Ng I.O.L.,
Young K., Chan J.K.F., Tso W.K., Yuen K.Y. and Wong
J., Ten-year experience with liver transplantation
at Queen Mary Hospital, Hong Kong Medical Journal.
2002, 8: 240-244.
|
|
Nanji A.A.,
Lau G.,
Tipoe G.L.,
Yuen S.T.,
Chen Y.X., Thomas P. and Lan H.Y., Macrophage migration
inhibitory factor expression in male and female ethanol-fed
rats, Journal of Interferon and Cytokine Research.
2001, 21(12): 1055-1062.
|
|
Wong B.C.Y.,
Wang W.H., Wong W.M., Lau
G., Fung F.M.Y., Kung N.N.S., Chu
K.M., Lai K.C., Hu W.H.C., Hu F.L., Liu X.G., Chan
C.K., Yuen M.F., Hui
W.M. and Lam
S.K., Three-day Lansoprazole quadruple therapy
for Helicobacter pylori-positive duodenal ulcers: a
randomized controlled study, Alimentary
Pharmcology and Therapeutics. 2001, 15: 843-850.
|
|
Lau G.K.K.,
Leung A.Y.H.,
Fong D.Y.T.,
Au W.Y., Kwong Y.L., Lie A.K.W., Hou
J.L., Wen Y.M., Nanji
A.A. and Liang
R.H.S., High hepatitis B virus (HBV) DNA viral
load as the most important risk factor for HBV reactivation
in patients positive for HBV surface antigen undergoing
autologous hematopoietic cell transplantation, Blood.
2002, 99: 2324-2330.
|
|
Lau K.S.,
Chan V.N.Y.
and Kung A.W.C.,
Genetic Mapping for thyrotoxic Periodic Paralysis,
Second International Huaxia Congress of Endocrinology,
Hong Kong, December 2001.
|
| Project Title: | Elucidation of the
mechanism of impaired mannose binding lectin production
in systemic lupus erythematosus |
| Investigator(s): | Prof.
Lau W.C.S. |
| Department: | Medicine |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | July 1999 |
| Abstract: |
| To investigate: 1) if impaired MBL production
in SLE is associated with promoter polymorphisms of
other genes, including those of interleukin 6 (IL6),
tumour necrosis factor alpha (TNF-alpha) and heat
shock protein (HSP); 2) whether codon 54 mutation and
promoter polymorphism of the MBL gene correlate with
promoter polymorphism of the above cytokine genes;
if low serum MBL level in SLE is due to the presence
of anti-MBL antibodies. |
| Project Title: | Towards a better understanding
of the role of nitric oxide in the pathogenesis of
systemic sclerosis |
| Investigator(s): | Prof.
Lau W.C.S., Prof. Fung P.C.W., Dr. Mok T.M.Y. |
| Department: | Medicine |
| Source(s) of Funding: | RGC
Fundable Projects (Block Grant Funded) |
| Start Date: | November 2000 |
| Abstract: |
| To evaluate the role of nitric oxide (NO) in
the pathogenesis of systemic sclerosis (SSc). |
| Project Title: | A study to investigate
the handling of apoptotic cells by phagocytes in systemic
lupus erythematosus (SLE) |
| Investigator(s): | Prof.
Lau W.C.S., Dr. Ren Y. |
| Department: | Medicine |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | November 2001 |
| Abstract: |
| To evaluate the ability of macrophages to clear
apoptotic neutrophils in SLE; to evaluate whether defects
in the clearance of apoptotic cells correlate with
overall disease activity in SLE; to evaluate whether
defects in the clearance of apoptotic cells correlate
with serum levels of anti-dsDNA antibodies, interleukin-10
(IL-10), IL-10 and macrophage migration inhibitory
factor (MIF) in patients with SLE; to study whether
anti-dsDNA antibodies, IL-10 and MIF influence the
ability of SLE phagocytes to ingest apoptotic neutrophils. |
|
Chan D.T.M.,
Wong R.W.S.,
Lau W.C.S.,
Tsang E.W.K., Ji Y.L., Mok M.Y., Tong M.K.L., Wong
A.K.M. and Lai K.N.,
Prolonged follow-up of patients with diffuse proliferative
lupus nephritis (DPLN) treated with prednisolone and
mycophenolate mofetil (MMF). [Abstract presented at
the Annual Meting of the American Society of Nephrology,
Oct 10-17, 2001, San Francisco, USA], Journal of
the American Society of Nephrolgoy. 2001, 12: 195A.
|
|
Chu E.M.Y. and Lau
W.C.S., A new model of health identified through
qualitative and quantitative analysis of the Chinese
arthritis impact measurement scales 2 Cultural issues
in the translation and validation of health status
measures, Arthritis & Rheumatism. 2001, 44(9
supple):2016: S389.
|
|
Ip E.W.K.,
Lau Y.L. and
Lau W.C.S.,
Phenotypic Deficiencies of Monocyte-Derived Dendritic
Cells in Systemic Lupus Erythematosus, The Hong
Kong Practitioner. 2002, 24(2)suppl: 66.
|
|
Ip E.W.K.,
Lau W.C.S.
and Lau Y.L.,
Phenotypic deficiencies of monocyte-derived dendritic
cells in systemic lupus erythematosus, Arthritis
& Rheumatism. 2001, 44(9 Supple):47: S60.
|
|
Lau W.C.S.,
Lo Y. and Mok T.M., The
use of complementary and alternative medicines in rheumatic
diseases in Chinese, Arthritis & Rheumatism.
2001, 44(9 Supple):949: S211.
|
|
Li C.W.P., Yung P.M.B., Chu E.M.Y., Lau
W.C.S. and Leung B.P.K., The efficacy of a
combined joint protection and behavioral management
program on the functional status of patients with rheumatoid
arthritis, Arthritis & Rheumatism. 2001, 44(9
Supple):673: S165.
|
|
Mok C.C., Ho C.T.K.,
Szeto M.L. and Lau
W.C.S., Effect of menopausal status on damage
in patients with systemic lupus erythematosus (SLE),
Arthritis & Rheumatism. 2001, 44(9 supple):1424:
S290.
|
|
Mok C.C., Lau
W.C.S. and Wong
R.W.S., Neuropsychiatric manifestations and their
clinical associations in Southern Chinese patients
with systemic lupus erythematosus, Journal of Rheumatology.
2001, 28(4): 766-771.
|
|
Mok C.C., Ho C.T.K.,
Chan W.K.,
Lau W.C.S.
and Wong R.W.S.,
Outcome and prognostic indicators of diffuse proliferative
lupus glomerulonephritis (SLE-DPGN) treated with sequential
oral cyclophosphamide (CYC) and azathioprine (AZA),
Arthritis & Rheumatism. 2001, 44(9 Supple):1369:
S281.
|
|
Mok C.C., Ho C.T.K.,
Siu Y.P., Chan K.W., Kwan T.H., Lau
W.C.S., Wong
R.W.S. and Au T.C., Treatment of diffuse proliferative
lupus glomerulonephritis: a comparison of two cyclophosphamide-containing
regimens, American Journal of Kidney Diseases.
2001, 28(2): 256-64.
|
|
Mok T.M., Ip E.W.K., Lau Y.L., Lo
Y. and Lau
W.C.S., Is mannose binding lectin (MBL) gene
polymorphism predictive of damage in systemic lupus
erythematosus (SLE)?, Arthritis & Rheumatism.
2001, 44(9 Supple):1162: S246.
|
|
Tong T.K., Yeung
J.S.L., Fung D.M., Lai
C.L. and Lau
W.C.S., Alterations of CD8+CD28- T cells in
systemic lupus erythematosus (SLE) and rheumatoid arthritis
(RA), 20th Congress of the ILAR. 2001, W13:
79.
|
|
Tong T.K., Yeung
J.S.L., Yang
D., Wu A.Y.Y.,
Chan W.K.,
Chiu P.K.Y.,
Tang W.M. and
Lau W.C.S.,
Effects of triptolide, an active ingredient of trypterygium
Wilfordii Hook F (Thunder God Vine, a traditional Chinese
herb), on rheumatoid synovial fibroblast function,
The Hong Kong Practitioner. 2001, 23(2)(Supple):
33.
|
|
Tong T.K., Yeung
J.S.L., Yang
D., Wu A.Y.Y.,
Chan W.K.,
Chiu P.K.Y.,
Tang W.M. and
Lau W.C.S.,
Effects of triptolide, an active ingredient of trypterygium
Wilfordii hook F (thunder god vine, a traditional Chinese
herb), on rheumatoid synovial fibroblast function,
Annals of the Rheumatic Diseases. 2001, 8(supple):
107.
|
|
Tsao B.P., Grossman J.M., Riemekasten G., Kalsi J.,
Wallace D.J., Chen C.J. and Lau
W.C.S., Familiarity of clinical features of
SLE in affected sibpairs, Arthrits & Rheumatism.
2001, 44(9 Supple):1174: S248.
|
|
Tsao B.P., Cantor R.M., Grossman J.M., Kim S.K., Wallace
D.J., Chen C.J., Lau
W.C.S., Ginzler E.M., Goldstein R., Shen N.,
Kalunian K.C., Arnett F.C. and Hahn B.H., Interaction
of loci at 1Q23 and IBD1 may contribute to SLE susceptibility,
Arthritis & rheumatism. 2001, 44(9 Supple):1173:
S248.
|
|
Wu A.Y.Y.,
Chan W.K.,
Chik S.C.C.,
Ren Y. and
Lau W.C.S.,
B cells from SLE patients display accelerated apoptosis
and reduced anti-apoptotic response to sIgM and CD40
ligation, The Hong Kong Practitioner. 2001,
23(2)(Supple): 33.
|
|
Yeung D., Ng G., Wong
R.W.S. and Lau
W.C.S., Rehabilitation of patients with rheumatoid
arthritis by Tai Chi Chuen training, Arthritis &
Rheumatism. 2001, 44(9 Supple):947: S210.
|
|
Cheung B.M.Y.,
Law C.Y.,
Tam S.C.F.,
Kumana C.R.
and Lau C.P.,
Plasma renin and aldosterone in patients with essential
hypertension, 7th Scientific Meeting of the Hong
Kong Pharmacology Society in Association with the Zhejiang
Pharmacological Society, Hong Kong 2001.
|
|
Cheung B.M.Y.,
Lam T.C., Law
C.Y., Kumana
C.R. and Lau
C.P., The relationship between blood pressure and
obesity in Hong Kong Chinese, 2nd Congress of Asian-Pacific
Society of Hypertension, Pattaya 2001.
|
|
Fan Y.Y., Lee K.L.F.,
Chow W.H., Chau E. and Lau
C.P., Internal cardioversion of chronic atrial
fibrillation during percutaneous mitral commissurotomy:
insight into reversal of chronic stretch-induced atrial
remodeling., Circulation. 2002, 105: 2746-2752.
|
|
Lee K.L.F.
and Lau C.P.,
Should all implantable cardioverter defibrillators
for ventricular arrhythmias be dual-chamber devices?,
Curr Cardiol Rep.. 2001, 3: 447-50.
|
|
Tse E.Y.Y.,
Lee K.L.F.
and Lau C.P.,
Adenosine triphosphate enhanced contrast pulmonary
venogram to facilitate pulmonary vein ablation., J
Cardiovasc Electrophysiol. 2002, 13: 300.
|
|
Tse H.F., Lee K.L.F.,
Fan Y.Y. and
Lau C.P., Nonfluoroscopic
magnetic electroanatomic mapping to facilitate focal
pulmonary viens ablation for paroxysmal atrial fibrillation.,
Pacing Clin Electrophysiol. 2002, 25: 57-61.
|
|
Xu W.,
Tse H.F., Chan F.H.Y., Fung P.C.W., Lee K.L.F.
and Lau C.P.,
New Bayesian discriminator for detection of atrial
tachyarrhythmias, Circulation
(Journal of the American Heart Association). Philadelphia,
USA, LWW, 2002, 105 (Issue 12): 1472-1479.
|
|
Yu C.M., Tse H.F., Chau
M.C., Fan Y.Y.,
Lee K.L.F.,
Leung S.K., Wan S.H. and Lau
C.P., 雙心室起搏治療心力衰竭的初步經驗, In: , 中華心律失常學雜誌, 2002,
4.
|
| Project Title: | Studies on cytochrome
P450 CYP2C9 genetic polymorphism in Chinese patients
receiving warfarin |
| Investigator(s): | Dr.
Leung A.Y.H., Prof. Liang R.H.S. |
| Department: | Medicine |
| Source(s) of Funding: | Kadoorie
Charitable Foundations |
| Start Date: | September 1999 |
| Abstract: |
| To characterize the sequences of the CYP2C9
gene in Chinese patients using a polymerase chain reaction
(PCR)-restriction endonuclease digestion method; to
correlate the occurrence of polymorphic alleles with
the dose of warfarin used for anticoagulation. |
|
Choi C.Y., Leung
A.Y.H., Fung
P.C.W., Lie
A.K.W. and Lie
A.K.W., Plasma Nitric Oxide predicts the occurrence
of moderate to severe acute graft versus host disease
in bone marrow transplant recipients, Hematologica.
2001, 86, September -14: 972-976.
|
|
Lau G., Leung A.Y.H.,
Au W.Y., Kwong Y.L., Lie A.K.W., Liang R.H.S.,
Hou J., Nanji A.A.
and Fong D.Y.T.,
High HBV DNA viral load is the most significant risk
factor for hepatitis B reactiation in hepatitis B surface
antign positive patients treated with autologous hematopoietic
stem cell transplantation, Blood.
2002, 99: 2324-2330.
|
|
Lau G.K.K.,
Leung A.Y.H.,
Fong D.Y.T.,
Au W.Y., Kwong Y.L., Lie A.K.W., Hou
J.L., Wen Y.M., Nanji
A.A. and Liang
R.H.S., High hepatitis B virus (HBV) DNA viral
load as the most important risk factor for HBV reactivation
in patients positive for HBV surface antigen undergoing
autologous hematopoietic cell transplantation, Blood.
2002, 99: 2324-2330.
|
|
Leung A.Y.H.,
Suen C., Chow C.H.,
Liang R.H.S.,
Lie A.K.W.
and Kwong Y.L.,
Quantitative and genotypic analysis of polyoma BK viruria
during hemorrhagic cystitis complicating bone marrow
transplantation., 43rd Annual Meeting of American
Society of Hematology, Orlando, USA.. 2001.
|
| Project Title: | Mechanism of IgA-induced
glomerular and tubulointerstitutial injury: role of
macrophage migration inhibitory factor (MIF) |
| Investigator(s): | Mr.
Leung J.C.K., Prof. Lai K.N., Dr. Lan H.Y. |
| Department: | Medicine |
| Source(s) of Funding: | Hong
Kong Research Grants Council Competitive Earmarked
Research Grants |
| Start Date: | December 2000 |
| Abstract: |
| To test the hypothesis that deposition of the
polymeric IgA within the kidney may cause migration
inhibitory factor (MIF) upregulation by glomerular
mesangial cell and tubular epithelial cells. |
| Project Title: | The role of the proximal
tubular epithelial cell as a proinflammatory and profibrotic
cell in kidney disease: insight from its interaction
with monocyte |
| Investigator(s): | Mr.
Leung J.C.K., Prof. Lai K.N. |
| Department: | Medicine |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | November 2001 |
| Abstract: |
| To examine whether stimulated monocyte cocultured
with proximal tubular epithelial cells (PTEC) will
induce tubular expression of complement, chemokine,
adhesion molecule, and growth factor; to examine the
chemotactic ability of mediators derived from tubular
cells; to explore whether the presence of adjacent
T cells may aggravate fibrogenic cytokine-induced tubular
epithelial-mesenchymal transdifferentiation. |
| Project Title: | Role of monocyte and
neutrophil in the pathogenesis of IgA nephropathy |
| Investigator(s): | Mr.
Leung J.C.K., Prof. Lai K.N. |
| Department: | Medicine |
| Source(s) of Funding: | Hong
Kong Research Grants Council Competitive Earmarked
Research Grants |
| Start Date: | December 2001 |
| Abstract: |
| To examine the characteristics of monocyte-
and neutrophil- bound IgA in patients and IgAN; to
investigate in-depth the role of monocyte and neutrophil
in the handling and metabolism of IgA in IgAN; to explore
the pathophysiologic effect of polymeric IgA from patients
on monocyte and neutrophil. |
|
Leung J.C.K.,
Lan H.Y., Tang C.S.O., Chan D.T.M. and
Lai K.N., Polymeric
IgA up-regulates macrophage migration inhibitory factor
(MIF) in human mesangial cell. [Abstract presented
at the Annual Meeting of the American Society of Nephrology,
Oct 10-17, 2001, San Francisco, USA], Journal of
the American Society of Nephrology. 2001, 12: 112A-113A.
|
|
Tang S.C.W.,
Leung J.C.K.,
Lam C.W., Lam
M.F., Chan D.T.M.
and Lai K.N.,
In vitro studies of aquaporins 1 and 3 expression in
cultured human proximal tubular cells: upregulation
by transferrin but not albumin, American Journal
of Kidney Diseases. 2001, 38(2): 317-330.
|
|
Tang S.C.W.,
Leung J.C.K.,
Chan K.W., Chan Y.Y., Chan D.T.M. and
Lai K.N., Induction
of interleukin-8 in human proximal tubule cells: an
in vitro and in vivo study. [Abstract presented at
the Annual Meeting of the American Society of Nephrology,
Oct 10-17, 2001, San Francisco, USA], Journal of
the American Society of Nephrology. 2001, 12: 664A-665A.
|
|
Chan D.T.M.,
Leung J.K.H.,
Lai K.N. and
Yung S.S.Y.,
Mechanisms of interaction between anti-DNA antibodies
and human mesangial cells in systemic lupus erythematosus
[presented at the 33rd Annual Meeting of the American
Society of Nephrology], Journal of American Society
of Nephrology. October 11-16, Toronto, Canada,
2001, 11: A2492.
|
|
Ip M.S.M.,
Tipoe G.L.,
Leung T.M.,
Zheng L., Shum D.K.Y.,
Tsang K.W.T.
and Lam W.K.,
Sputum sol in bronchiectasis stimulates IL-6 production
from bronchial epithelial cells, American Thoracic
Society International Conference, San Francisco, USA,
2001. American Journal of Respiratory & Critical Care
Medicine. 2001, 163(5): A467.
|
|
Chan L.Y.,
Fong D., Lam C.L., Chan
M.M.W., Say J.T.K., Leung
Y.H., Zheng L., Ooi
C.G.C., Ip
M.S.M., Lam
W.K. and Tsang
K.W.T., Validation of the Hong Kong Chinese version
of St Georges' Respiratory Questionnaire, The Hong
Kong Practitioner. 2002, 23 Suppl 2: 30.
|
|
Ho J.C.M., Chan K.N., Hu
H.C., Lam W.K.,
Zheng L., Tipoe
G.L., Sun J.Z.,
Leung Y.H.
and Tsang K.W.T.,
The effect of aging on nasal mucociliary clearance,
beat frequency and ultrastructure of respiratory cilia,
American
Journal of Respiratory and Critical Care Medicine.
2001, 163: 983-988.
|
|
Ho J.C.M., Hu H.C.,
Lam W.K., Chu L.W., Zheng
L., Tipoe G.L.,
Ooi C.G.C.,
Sun J.Z., Leung Y.H.,
Ip M.S.M.,
Chan M.M.W.
and Tsang K.W.T.,
The effect of aging on nasal mucociliary clearance,
beat frequency and ultrastructure of respiratory cilia,
Medical Research Conference, University Department
of Medicine, Hong Kong, 2001. The Hong Kong Practitioner.
2001, 23 (suppl 2): 66 (S-RM-5).
|
|
Shum H.Y.I.,
Zheng L., Taylor G., Lam
W.K., Fung P.C.W.,
Leung Y.H.,
Sun J.Z., Tipoe G.L. and
Tsang K.W.T.,
Pseudomonas aeruginosa 1-hycroxyphenazine stimulates
iNOS expression in human respiratory mucosa, American
Journal of Respiratory and Critical Care Medicine.
2001, 163(5): A670.
|
|
Zheng L., Lam W.K.,
Shum H.Y.I.,
Tipoe G.L.,
Yan C.P.K.,
Leung Y.H.,
Sun J.Z., Ooi C.G.C., Ip M.S.M. and
Tsang K.W.T.,
Expression of matric matelloproteinase-8 and 9 is raised
in the airways of patients with bronchiectasis in vivo,
The Hong Kong Practitioner. 2001, 23(Suppl 2):
64.
|
|
Zheng L., Lam W.K.,
Shum H.Y.I.,
Tipoe G.L.,
Yan C.P.K.,
Leung Y.H.,
Sun J.Z., Ooi C.G.C., Ip M.S.M. and
Tsang K.W.T.,
Over expression of matrix metalloproteinase-8 (MMP-8)
and -9 (MMP-9) in bronchiectatic airways in vivo, Medical
Research Conference, University Department of Medicine,
Hong Kong, 2001. The Hong Kong Practitioner. 2001,
23 (suppl 2): 64 (S-RM-1).
|
|
Zheng L., Lam W.K.,
Tipoe G.L.,
Shum H.Y.I.,
Yan C.P.K.,
Leung Y.H.,
Sun J.Z., Ooi C.G.C. and
Tsang K.W.T.,
Overexpression of matrix metalloporteinase-8 and -9
in bronchiectatic airways in vivo, European Respiratory
Journal. 2002, 20: 170-176.
|
|
Lo W.K., Tong
K.L., Li C.S.,
Chan D.T.M.,
Wong A.K.M., Ho Y.W., Cheung K.O., Kwan T.H., Wong
K.S., Ng F.S.K.
and Cheng I.K.P.,
Relationship between adequacy of dialysis and nutritional
status and their impact on patient survival in CAPD
in Hong Kong, In: , Peritoneal
Dialysis International. 2001, 21(5): 441-447.
|
|
Choy C.B.Y.,
Lo W.K., Chan D.T.M., Lui S.L., Tang
S.C.W., Lam M.F., Li
F.K. and Lai
K.N., A randomised prospective comparison of intermittent
versus continuous dosing regimens of intraperitoneal
cefozolin and tobramycin in the treatment of CAPD preitonitis.
[Abstract presented at the Annual Meeting of the American
Society Nephrology, Oct 10-17, 2001, San Francisco,
USA], Journal of the American Society of Nephrology.
2001, 12: 425A.
|
|
Choy C.B.Y.,
Chan D.T.M.,
Li F.K.,
Lui S.L., Lo W.K. and Lai K.N., Long-term
outcome of renal transplant in patients with hepatitis
B or C. [Abstract presented at the European Dialysis
and Transplantation Association XXXIX Congress, July
14-17, 2002, Copenhagen, Denmark], Nephrology Dialysis
Transplantation. 2002, 17(Suppl 7): 314.
|
|
Tang S.C.W.,
Chan D.T.M.,
Li F.K.,
Choy C.B.Y.,
Tang A., Ho Y.W. and Lai
K.N., Spousal renal donor transplantation in Chinese:
a ten-year experience from two regional hospitals in
Hong Kong. [Abstract presented at the European Dialysis
and Transplantation Association XXXIX Congress, July
14-17, 2002, Copenhagen, Denmark], Nephrology Dialysis
Transplantation. 2002, 17(Suppl 7): 320.
|
|
Li G.,
Liu H.L., Cheung R.T.F., Hung Y.C., Chen J.C., Cao
G., Wong K.K.,
Chou A., Wai Y.Y., Shen
G.G., Ma Q.
and Yang E.S.,
A fMRI Study of Correlation Between Acupointsj and
Brain Cortical Sites Involved in Language Functions.
Tenth Scientific Meeting & Exhibition, Honolulu, Hawaii,
Proc. of Inter. Soc. for Magnetic Resonance in Medicine,
2002, Vol. 2: P. 1523.
|
| Project Title: | Translational research
in blood cancers and stem cell transplantation |
| Investigator(s): | Prof.
Liang R.H.S., Prof. Kwong Y.L. |
| Department: | Medicine |
| Source(s) of Funding: | Kadoorie
Charitable Foundations |
| Start Date: | January1999 |
| Abstract: |
| Modern molecular and cellular techniques are
applied for the diagnosis and treatment of blood cancers. |
| Project Title: | Molecular genetics
of common cancers in Hong Kong |
| Investigator(s): | Prof.
Liang R.H.S., Prof. Kwong Y.L. |
| Department: | Medicine |
| Source(s) of Funding: | Kadoorie
Charitable Foundations |
| Start Date: | March 2000 |
| Abstract: |
| To investigate the genetic changes of the common
cancers in Hong Kong. |
|
Au W.Y., Luo
X., Liang R.H.S.
and Lau G.,
Hepatitis B virus reactivation after cytotoxic or immunosuppresive
therapy, pathogenesis and management, Rev Med Virol.
2001, 5: 287-299.
|
|
Au W.Y., Lie A.K.W., Kwong Y.L., Shek T.W.H., Hawkins B.R., Lai K.N., Tang
S.C.W., Lo
C.M., Fan S.T.,
Liu C.L., Chan G.C.F., Chau M.C., Chiu S.W. and
Liang R.H.S.,
Post-transplantation lymphoproliferative disease in
Chinese: the Queen Mary Hospital experience in Hong
Kong, Leukemia and Lymphoma. 2002, 43: 1405-14September .
|
|
Au W.Y., Lie A.K.W., Liang R.H.S.,
Chan G.C.F.
and Kwong Y.L.,
Sustained and Repeated Response of Relapsed Acute Promyelocytic
Leukaemia to Intravenous or Oral Arsenic Trioxide,
7th Medical Research Conference, Hong Kong, 26-27
January 2002. 24(2): 46.
|
|
Chim J.C.S.,
Liang R.H.S.,
Wong A.S.Y.
and Kwong Y.L.,
Methylation profiling in acute leukaemia., American
Association for Cancer Research Satellite Meeting on
cancer and chromosomal organization : Epigenetics of
Cancer. San Francisco, USA.. 2001.
|
|
Ha S.Y., Chan G.C.F., Lee
A.C.W., Liang
R.H.S. and Lau
Y.L., Cord Blood and Marrow Transplant for Thalassaemic
Patients: A Single Centre Experience, The 23rd International
Congress of Pediatrics, Chinese Medical Association,
Beijing, PR China, 9-14 September 2001. 153.
|
|
Ha S.Y., Chan G.C.F., Ma E.S.K., Liang R.H.S.,
Kwong Y. and Lau
Y.L., Treatment outcome and chimerism status after
cord blood or bone marrow transplant in transfusion-dependent
thalassaemia patients, 28th Annual Meeting of the
European Group for Blood and Marrow Transplantation,
Montreux, Switzerland, 24-27 March 2002.
|
|
Lau A.K.L.,
Liang R.H.S.,
Lie A.K.W.,
Tai J.W.M. and Fong
D.Y.T., Cross-sectional Study of the Quality of
Life of Chinese Adult Bone Marrow Transplant Survivors,
8th Hong Kong International Cancer Congress 6th
Research Postgraduate Symposium. Hong Kong, Faculty
of Medicine, The University of Hong Kong, 2001, 11.
|
|
Lau A.K.L., Liang
R.H.S., Lie
A.K.W., Tai J.W.M. and Fong D.Y.T., Cross-sectional
study of the quality of life of Chinese adult bone
marrow transplant survivors., 8th Hong Kong International
Cancer Congress.. 2001.
|
|
Lau A.K.L.,
Chang C.H., Tai J.W.M., Eremenco S., Liang
R.H.S., Lie
A.K.W., Fong
D.Y.T. and Lau
C.M., Quality of life - Translation and validation
of the Functional Assessment of Cancer Therapy-Bone
Marrow Transplant (FACT-BMT) Version 4 quality of life
instrument into traditional Chinese, Bone Marrow
Transplantation. London, U.K., Macmillan Publishers
Ltd, 2002, 29: 41-49.
|
|
Lau G., Ngan
R., He M.L., Cheung M.C., Yiu H.Y., Cheng H.C., Lie A.K.W., Kung
K.F. and Liang
R.H.S., A randomised study of lamivudine for
prevention of HBV reactivation in HbsAg seropositive
patients undergoing cytotoxic chemotherapy., Annual
Meeting of the American Association for study of Liver
Diseases.. 2002.
|
|
Lau G., Suri
D., Liang R.H.S.,
Rigoponlon E.I., Thomas M.G., Mullerova , Yuen
S.T., Williams R. and Naoumov N.V., Adoptive transfer
of immunity to hepatitis B virus nucleocapsid protein
terminates chronic HBV infection., Gastroenterology.
2002, 122: 614-624.
|
|
Lau G., Leung A.Y.H.,
Au W.Y., Kwong Y.L., Lie A.K.W., Liang R.H.S.,
Hou J., Nanji A.A.
and Fong D.Y.T.,
High HBV DNA viral load is the most significant risk
factor for hepatitis B reactiation in hepatitis B surface
antign positive patients treated with autologous hematopoietic
stem cell transplantation, Blood.
2002, 99: 2324-2330.
|
|
Lau G., Au W.Y., Lie
A.K.W., Fong D.Y.T., Kwong
Y.L. and Liang
R.H.S., Reduction of hepatitis due to HBV reactivation
in HbsAg positive patients undergoing allogeneic bone
marrow transplantation with pre-emptive lamuvidine
treatment., 52th Annual Meeting of American Association
for study of Liver disease.. 2001.
|
|
Lau G., Suri
D., Liang R.H.S.,
Rigopoulou E.I., Thomas M.G., Mullerova I., Nanji
A.A., Yuen
S.T., Williams R. and Naoumov N.V., Resolution
of chronic hepatitis B and anti-HBs seroconversion
in humans by adoptive transfer of immunity to hepatitis
B core antigen, Gastroenterology.
2002, 122(3): 614-624.
|
|
Lau G.K.K.,
Leung A.Y.H.,
Fong D.Y.T.,
Au W.Y., Kwong Y.L., Lie A.K.W., Hou
J.L., Wen Y.M., Nanji
A.A. and Liang
R.H.S., High hepatitis B virus (HBV) DNA viral
load as the most important risk factor for HBV reactivation
in patients positive for HBV surface antigen undergoing
autologous hematopoietic cell transplantation, Blood.
2002, 99: 2324-2330.
|
|
Leung A.Y.H.,
Suen C., Chow C.H.,
Liang R.H.S.,
Lie A.K.W.
and Kwong Y.L.,
Quantitative and genotypic analysis of polyoma BK viruria
during hemorrhagic cystitis complicating bone marrow
transplantation., 43rd Annual Meeting of American
Society of Hematology, Orlando, USA.. 2001.
|
|
Liang R.H.S.,
Aggressive non-Hodgkin's lymphoma - current management
strategies., 4th Malaysian National Haematology
Scientific Meeting, Penang, Malaysia.. 2002, 63.
|
|
Liang R.H.S.,
Implication and treatment of hepatitis B in malignant
hematology., 4th Malaysian National Haematology
Scientific Meeting, penang, Malaysia.. 2002, 33.
|
|
Luo X., Chang C.H., Tai J.W.M., Eremenco S., Liang R.H.S.,
Lie A.K.W.
and Fong D.Y.T., Translation and validation of the
functional assessment of cancer therapy-bone marrow
transplant verison 4 quality of life instrument into
traditional Chinese., Bone Marrow Transplantation.
2002, 29: 41-49.
|
|
Man C., Lam W.K.,
Liang R.H.S.
and Kwong Y.L.,
Genetic imbalances in lung cancer in Hong Kong by comparative
genomic hybridization, Chest. 2001, 120(4)(suppl):
317S.
|
|
Man C.W.Y.,
Lam W.K., Liang R.H.S.
and Kwong Y.L.,
Genetic imbalances in lung cancer in Hong Kong by comparative
genomic hybridisation., Annual International Conference
of American College of Chest Physicians. Philadelphia,
USA,. 2001.
|
|
Zhou X., Ha S.Y., Chan
G.C.F., Luk C.W., Chan
V.N.Y., Hawkins
B.R., Lam Y.H.,
Liang R.H.S.
and Lau Y.L.,
Successful mismatched sibling cord blood transplant
in Hb Bart's disease, Bone Marrow Transplantation.
2001, 28: 105-107.
|
|
Au W.Y., Lie A.K.W.,
Hon C., Yeung C.K., Chan
H.H.L. and Ma S.Y., Keratodrema blenorrhagica,
balanitis and uveitis after HLA-B15 mismatched bone
marrow transplantation, Haematologica. 2002,
ERC13.
|
|
Au W.Y., Lie A.K.W.,
Kwong Y.L.,
Shek T.W.H.,
Hawkins B.R.,
Lai K.N., Tang S.C.W., Lo C.M., Fan
S.T., Liu C.L.,
Chan G.C.F.,
Chau M.C.,
Chiu S.W. and
Liang R.H.S.,
Post-transplantation lymphoproliferative disease in
Chinese: the Queen Mary Hospital experience in Hong
Kong, Leukemia and Lymphoma. 2002, 43: 1405-14September .
|
|
Au W.Y., Lie A.K.W.,
Liang R.H.S.,
Chan G.C.F.
and Kwong Y.L.,
Sustained and Repeated Response of Relapsed Acute Promyelocytic
Leukaemia to Intravenous or Oral Arsenic Trioxide,
7th Medical Research Conference, Hong Kong, 26-27
January 2002. 24(2): 46.
|
|
Choi C.Y., Leung
A.Y.H., Fung
P.C.W., Lie
A.K.W. and Lie
A.K.W., Plasma Nitric Oxide predicts the occurrence
of moderate to severe acute graft versus host disease
in bone marrow transplant recipients, Hematologica.
2001, 86, September -14: 972-976.
|
|
Lau A.K.L.,
Liang R.H.S.,
Lie A.K.W.,
Tai J.W.M. and Fong
D.Y.T., Cross-sectional Study of the Quality of
Life of Chinese Adult Bone Marrow Transplant Survivors,
8th Hong Kong International Cancer Congress 6th
Research Postgraduate Symposium. Hong Kong, Faculty
of Medicine, The University of Hong Kong, 2001, 11.
|
|
Lau A.K.L., Liang
R.H.S., Lie
A.K.W., Tai J.W.M. and Fong D.Y.T., Cross-sectional
study of the quality of life of Chinese adult bone
marrow transplant survivors., 8th Hong Kong International
Cancer Congress.. 2001.
|
|
Lau A.K.L.,
Chang C.H., Tai J.W.M., Eremenco S., Liang
R.H.S., Lie
A.K.W., Fong
D.Y.T. and Lau
C.M., Quality of life - Translation and validation
of the Functional Assessment of Cancer Therapy-Bone
Marrow Transplant (FACT-BMT) Version 4 quality of life
instrument into traditional Chinese, Bone Marrow
Transplantation. London, U.K., Macmillan Publishers
Ltd, 2002, 29: 41-49.
|
|
Lau G., Ngan
R., He M.L., Cheung M.C., Yiu H.Y., Cheng H.C., Lie A.K.W.,
Kung K.F. and Liang
R.H.S., A randomised study of lamivudine for prevention
of HBV reactivation in HbsAg seropositive patients
undergoing cytotoxic chemotherapy., Annual Meeting
of the American Association for study of Liver Diseases..
2002.
|
|
Lau G., Leung A.Y.H.,
Au W.Y., Kwong Y.L., Lie A.K.W.,
Liang R.H.S.,
Hou J., Nanji A.A.
and Fong D.Y.T.,
High HBV DNA viral load is the most significant risk
factor for hepatitis B reactiation in hepatitis B surface
antign positive patients treated with autologous hematopoietic
stem cell transplantation, Blood.
2002, 99: 2324-2330.
|
|
Lau G., Au W.Y., Lie A.K.W.,
Fong D.Y.T., Kwong
Y.L. and Liang
R.H.S., Reduction of hepatitis due to HBV reactivation
in HbsAg positive patients undergoing allogeneic bone
marrow transplantation with pre-emptive lamuvidine
treatment., 52th Annual Meeting of American Association
for study of Liver disease.. 2001.
|
|
Lau G.K.K.,
Leung A.Y.H.,
Fong D.Y.T.,
Au W.Y., Kwong Y.L., Lie A.K.W.,
Hou J.L., Wen Y.M., Nanji
A.A. and Liang
R.H.S., High hepatitis B virus (HBV) DNA viral
load as the most important risk factor for HBV reactivation
in patients positive for HBV surface antigen undergoing
autologous hematopoietic cell transplantation, Blood.
2002, 99: 2324-2330.
|
|
Leung A.Y.H.,
Suen C., Chow C.H.,
Liang R.H.S.,
Lie A.K.W.
and Kwong Y.L.,
Quantitative and genotypic analysis of polyoma BK viruria
during hemorrhagic cystitis complicating bone marrow
transplantation., 43rd Annual Meeting of American
Society of Hematology, Orlando, USA.. 2001.
|
|
Luo X., Chang C.H., Tai J.W.M., Eremenco S., Liang
R.H.S., Lie
A.K.W. and Fong D.Y.T., Translation and validation
of the functional assessment of cancer therapy-bone
marrow transplant verison 4 quality of life instrument
into traditional Chinese., Bone Marrow Transplantation.
2002, 29: 41-49.
|
|
Yu C.M., Chau M.C., Sanderson
J.E., Fan Y.Y.,
Tang M.O.,
Fung W.H., Lin
H., Kong
S.L., Lam Y.M.,
Hill M.R. and Lau
C.P., Tissue Doppler echocardiographic evidence
of reverse remodeling and improved synchronicity by
simultaneously delaying regional contraction after
biventricular pacing therapy in heart failure., In:
, Circulation. 2002, 105: 438-45.
|
|
Cheung B.M.Y.,
Lo L.F.,
Lam T.H., Lam K.S.L., Lau C.P., Tam
S.C.F., Wat
N.M.S., Man
Y.B. and Cheng C.H., Follow up of the Hong Kong
cardiovascular risk factor prevalence survey cohort,
J HK Coll Cardiol. 2002, 10 (Supple): 129.
|
|
Cheung B.M.Y.,
Lo L.F.,
Lam T.H., Lam K.S.L., Lau C.P., Tam
S.C.F., Wat
N.M.S., Man
Y.B. and Cheng C.H., Six year follow up of the
Hong Kong cardiovascular risk factor prevalence survey
cohort, Cardiovascular Drugs Therapeutics. 2002,
16(Supple 1): 26-27.
|
|
Choy C.B.Y.,
Lo W.K.,
Chan D.T.M.,
Lui S.L., Tang S.C.W., Lam
M.F., Li F.K.
and Lai K.N.,
A randomised prospective comparison of intermittent
versus continuous dosing regimens of intraperitoneal
cefozolin and tobramycin in the treatment of CAPD preitonitis.
[Abstract presented at the Annual Meeting of the American
Society Nephrology, Oct 10-17, 2001, San Francisco,
USA], Journal of the American Society of Nephrology.
2001, 12: 425A.
|
|
Choy C.B.Y.,
Chan D.T.M.,
Li F.K., Lui S.L., Lo W.K. and
Lai K.N., Long-term
outcome of renal transplant in patients with hepatitis
B or C. [Abstract presented at the European Dialysis
and Transplantation Association XXXIX Congress, July
14-17, 2002, Copenhagen, Denmark], Nephrology Dialysis
Transplantation. 2002, 17(Suppl 7): 314.
|
|
Lo W.K.,
Cheng I.K.P.,
Ho Y.W., Choi K.S., Chan
D.T.M., Wong K.S. and Yu A.W.Y., Effect of Kt/V
on nutritional status and morbidity in CAPD patients
- a prospective randomized study. [Abstract presented
at the Annual Meeting of the American Society of Nephrology,
Oct 10-17, 2001, San Francisco, USA], Journal of
the American Society of Nephrology. 2001, 12: 452A-453A.
|
|
Lo W.K.,
Tong K.L., Li C.S.,
Chan D.T.M.,
Wong A.K.M., Ho Y.W., Cheung K.O., Kwan T.H., Wong
K.S., Ng F.S.K.
and Cheng I.K.P.,
Relationship between adequacy of dialysis and nutritional
status and their impact on patient survival in CAPD
in Hong Kong, In: , Peritoneal
Dialysis International. 2001, 21(5): 441-447.
|
|
Lau W.C.S.,
Lo Y.
and Mok T.M.,
The use of complementary and alternative medicines
in rheumatic diseases in Chinese, Arthritis & Rheumatism.
2001, 44(9 Supple):949: S211.
|
|
Mok T.M., Ip E.W.K., Lau Y.L., Lo Y. and
Lau W.C.S.,
Is mannose binding lectin (MBL) gene polymorphism predictive
of damage in systemic lupus erythematosus (SLE)?, Arthritis
& Rheumatism. 2001, 44(9 Supple):1162: S246.
|
|
Choy C.B.Y.,
Lo W.K., Chan D.T.M., Lui S.L.,
Tang S.C.W.,
Lam M.F., Li F.K.
and Lai K.N.,
A randomised prospective comparison of intermittent
versus continuous dosing regimens of intraperitoneal
cefozolin and tobramycin in the treatment of CAPD preitonitis.
[Abstract presented at the Annual Meeting of the American
Society Nephrology, Oct 10-17, 2001, San Francisco,
USA], Journal of the American Society of Nephrology.
2001, 12: 425A.
|
|
Choy C.B.Y.,
Chan D.T.M.,
Li F.K., Lui S.L.,
Lo W.K. and
Lai K.N., Long-term
outcome of renal transplant in patients with hepatitis
B or C. [Abstract presented at the European Dialysis
and Transplantation Association XXXIX Congress, July
14-17, 2002, Copenhagen, Denmark], Nephrology Dialysis
Transplantation. 2002, 17(Suppl 7): 314.
|
|
Man C.W.Y.,
Lam W.K., Liang R.H.S. and
Kwong Y.L.,
Genetic imbalances in lung cancer in Hong Kong by comparative
genomic hybridisation., Annual International Conference
of American College of Chest Physicians. Philadelphia,
USA,. 2001.
|
|
Cheung B.M.Y.,
Lo L.F., Lam T.H., Lam
K.S.L., Lau
C.P., Tam S.C.F.,
Wat N.M.S.,
Man Y.B.
and Cheng C.H., Follow up of the Hong Kong cardiovascular
risk factor prevalence survey cohort, J HK Coll
Cardiol. 2002, 10 (Supple): 129.
|
|
Cheung B.M.Y.,
Lo L.F., Lam T.H., Lam
K.S.L., Lau
C.P., Tam S.C.F.,
Wat N.M.S.,
Man Y.B.
and Cheng C.H., Six year follow up of the Hong Kong
cardiovascular risk factor prevalence survey cohort,
Cardiovascular Drugs Therapeutics. 2002, 16(Supple
1): 26-27.
|
|
Lau W.C.S.,
Lo Y. and Mok T.M.,
The use of complementary and alternative medicines
in rheumatic diseases in Chinese, Arthritis & Rheumatism.
2001, 44(9 Supple):949: S211.
|
|
Mok T.M.,
Ip E.W.K.,
Lau Y.L., Lo Y. and Lau
W.C.S., Is mannose binding lectin (MBL) gene polymorphism
predictive of damage in systemic lupus erythematosus
(SLE)?, Arthritis & Rheumatism. 2001, 44(9 Supple):1162:
S246.
|
|
Ip M.S.M.,
Lam B., Mok
W.Y.W., Ip
T.Y. and Lam
W.K., Prevalence of sleep disordered breathing
in middle-aged Chinese women in Hong Kong, American
Thoracic Society International Conference, San Francisco,
USA, 2001. American Journal of Respiratory & Critical
Care Medicine. 2001, 163(5): A636.
|
|
Lo W.K., Tong
K.L., Li C.S.,
Chan D.T.M.,
Wong A.K.M., Ho Y.W., Cheung K.O., Kwan T.H., Wong
K.S., Ng F.S.K.
and Cheng I.K.P.,
Relationship between adequacy of dialysis and nutritional
status and their impact on patient survival in CAPD
in Hong Kong, In: , Peritoneal
Dialysis International. 2001, 21(5): 441-447.
|
|
Ip M.S.M.,
Lam B., Ng M.M.T.,
Lam W.K., Tsang K.W.T. and
Lam K.S.L.,
Hyperinsulinemia in obstructive sleep apnea, American
Thoracic Society International Conference, San Francisco,
USA, 2001. American Journal of Respiratory & Critical
Care Medicine. 2001, 163(5): A637.
|
|
Tan K.C.B.,
Tso A.W.K., Pang
R.W.C. and Lam
K.S.L., Effects of Sandostatin LAR on lipoprotein
metabolism in patients with acromegaly - a six-month
prospective study, The Endocrine Society 83rd Annual
meeting. Denver, June 2001. 2002.
|
|
Tan K.C.B.,
Chow W.S., Wong
Y., Shiu
S.W.M. and Tam
S.C.F., Effects of Angiotensin II Receptor Antagonist
on Plasma C-reactive Protein and Urinary Albumin Excretion
in Type 2 Diabetic Patients with Microalbuminuria,
American Diabetes Association 62nd Annual Meeting
and Scientific Sessions. San Francisco, June 2002.
USA.
|
|
Tan K.C.B.,
Shiu S.W.M.
and Chu B.Y.M., Effects of gender, hepatic lipase gene
polymorphism and type 2 diabetes mellitus on hepatic
lipase activity in Chinese, Atherosclerosis.
2001, 157: 233-239 (A)[2.89].
|
|
Tan K.C.B.,
Shiu S.W.M.
and Wong Y.,
Glycaemic control is a major determinant of plasma
phospholipid transfer protein activity in patients
with type 2 diabetes mellitus, 5th International
Diabetes Federation Western Pacific Region Congress.
Beijing, May 2002. PRC.
|
|
Shum H.Y.I.,
Zheng L., Taylor G., Lam
W.K., Fung P.C.W.,
Leung Y.H.,
Sun J.Z., Tipoe G.L. and
Tsang K.W.T.,
Pseudomonas aeruginosa 1-hycroxyphenazine stimulates
iNOS expression in human respiratory mucosa, American
Journal of Respiratory and Critical Care Medicine.
2001, 163(5): A670.
|
|
Shum H.Y.I.,
Zheng L., Taylor G., Sun
J.Z., Tipoe
G.L., Ho J.C.M., Fung
P.C.W., Lam
W.K. and Tsang
K.W.T., Upregulation of iNOS expression in human
respiratory mucosa by Pseudomonas aeruginosa 1-hydroxyphenazine,
The Hong Kong Practitioner. 2001, 23(Suppl 2):
66.
|
|
Zheng L., Lam W.K.,
Shum H.Y.I.,
Tipoe G.L.,
Yan C.P.K.,
Leung Y.H.,
Sun J.Z., Ooi C.G.C., Ip M.S.M. and
Tsang K.W.T.,
Expression of matric matelloproteinase-8 and 9 is raised
in the airways of patients with bronchiectasis in vivo,
The Hong Kong Practitioner. 2001, 23(Suppl 2):
64.
|
|
Zheng L., Lam W.K.,
Shum H.Y.I.,
Tipoe G.L.,
Yan C.P.K.,
Leung Y.H.,
Sun J.Z., Ooi C.G.C., Ip M.S.M. and
Tsang K.W.T.,
Over expression of matrix metalloproteinase-8 (MMP-8)
and -9 (MMP-9) in bronchiectatic airways in vivo, Medical
Research Conference, University Department of Medicine,
Hong Kong, 2001. The Hong Kong Practitioner. 2001,
23 (suppl 2): 64 (S-RM-1).
|
|
Zheng L., Lam W.K.,
Tipoe G.L.,
Shum H.Y.I.,
Yan C.P.K.,
Leung Y.H.,
Sun J.Z., Ooi C.G.C. and
Tsang K.W.T.,
Overexpression of matrix metalloporteinase-8 and -9
in bronchiectatic airways in vivo, European Respiratory
Journal. 2002, 20: 170-176.
|
|
Zheng L., Shum
H.Y.I., Lam
W.K., Tipoe
G.L., Yan C.P.K.,
Ooi C.G.C.,
Ho J.C.M., Fung
P.C.W., Ip
M.S.M. and Tsang
K.W.T., Overexpression of matrix metalloproteinase-8
(MMP-8) and-9 in bronchiectatic airways in vivo, American
Journal of Respiratiry and Critical Care Medicine.
2001, 163(5): A671.
|
|
Ho J.C.M., Chan K.N., Hu
H.C., Lam W.K.,
Zheng L., Tipoe
G.L., Sun
J.Z., Leung
Y.H. and Tsang
K.W.T., The effect of aging on nasal mucociliary
clearance, beat frequency and ultrastructure of respiratory
cilia, American
Journal of Respiratory and Critical Care Medicine.
2001, 163: 983-988.
|
|
Ho J.C.M., Hu H.C.,
Lam W.K., Chu L.W., Zheng
L., Tipoe G.L.,
Ooi C.G.C.,
Sun J.Z.,
Leung Y.H.,
Ip M.S.M.,
Chan M.M.W.
and Tsang K.W.T.,
The effect of aging on nasal mucociliary clearance,
beat frequency and ultrastructure of respiratory cilia,
Medical Research Conference, University Department
of Medicine, Hong Kong, 2001. The Hong Kong Practitioner.
2001, 23 (suppl 2): 66 (S-RM-5).
|
|
Shum H.Y.I.,
Zheng L., Taylor G., Lam
W.K., Fung P.C.W.,
Leung Y.H.,
Sun J.Z.,
Tipoe G.L.
and Tsang K.W.T.,
Pseudomonas aeruginosa 1-hycroxyphenazine stimulates
iNOS expression in human respiratory mucosa, American
Journal of Respiratory and Critical Care Medicine.
2001, 163(5): A670.
|
|
Shum H.Y.I.,
Zheng L., Taylor G., Sun
J.Z., Tipoe
G.L., Ho J.C.M., Fung
P.C.W., Lam
W.K. and Tsang
K.W.T., Upregulation of iNOS expression in human
respiratory mucosa by Pseudomonas aeruginosa 1-hydroxyphenazine,
The Hong Kong Practitioner. 2001, 23(Suppl 2):
66.
|
|
Zheng L., Lam W.K.,
Shum H.Y.I.,
Tipoe G.L.,
Yan C.P.K.,
Leung Y.H.,
Sun J.Z.,
Ooi C.G.C.,
Ip M.S.M. and
Tsang K.W.T.,
Expression of matric matelloproteinase-8 and 9 is raised
in the airways of patients with bronchiectasis in vivo,
The Hong Kong Practitioner. 2001, 23(Suppl 2):
64.
|
|
Zheng L., Lam W.K.,
Shum H.Y.I.,
Tipoe G.L.,
Yan C.P.K.,
Leung Y.H.,
Sun J.Z.,
Ooi C.G.C.,
Ip M.S.M. and
Tsang K.W.T.,
Over expression of matrix metalloproteinase-8 (MMP-8)
and -9 (MMP-9) in bronchiectatic airways in vivo, Medical
Research Conference, University Department of Medicine,
Hong Kong, 2001. The Hong Kong Practitioner. 2001,
23 (suppl 2): 64 (S-RM-1).
|
|
Zheng L., Lam W.K.,
Tipoe G.L.,
Shum H.Y.I.,
Yan C.P.K.,
Leung Y.H.,
Sun J.Z.,
Ooi C.G.C.
and Tsang K.W.T.,
Overexpression of matrix metalloporteinase-8 and -9
in bronchiectatic airways in vivo, European Respiratory
Journal. 2002, 20: 170-176.
|
| Project Title: | Effects of genetic
variation in microsomal triglyceride transfer protein
expression on apolipoprotein B-containing lipoproteins
in diabetes |
| Investigator(s): | Dr.
Tan K.C.B. |
| Department: | Medicine |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | November 2000 |
| Abstract: |
| To determine whether MTP genetic variation
is accociated with changes in plasma apoB-containing
lipoproteins and in particular its effect on LDL size
fractions in Oriental subjects; to evaluate the role
of genetic variation of MTP activity in diabetic dyslipidaemia;
to evaluate the impact of MTP genetic variation on
postprandial lipaemia in type 2 diabetes mellitus. |
| Project Title: | Inflammation and advanced
glycation end products in diabetes mellitus |
| Investigator(s): | Dr.
Tan K.C.B. |
| Department: | Medicine |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | November 2001 |
| Abstract: |
| To investigate whether there is a relationship
between plasma CRP and AGEs concentrations in patients
with type 2 diabetes mellitus; to investigate the direct
effects of AGEs on hepatocyte CRP production; to investigate
whether CRP can modulate or potentiate the adverse
effects of AGEs on endothelial cells. |
|
Chow W.S., Tan
K.C.B., Tam
S.C.F., Ai V.H.G., Lam C.H.L. and Lam
K.S.L., Inflammation and endothelial dysfunction
in patients with type 2 diabetes mellitus, 2nd International
Huaxia Congress of Endocrinology. Hong Kong December,
2001. HK.
|
|
Chow W.S., Tan
K.C.B., Ai V.H.G. and Lam
K.S.L., Relationship of quantitative insulin sensitivity
check index and body fat mass and distribution in type
2 diabetes, 5th International Diabetes Federation
Western Pacific Region Congress. Beijing, May 2002.
PRC.
|
|
Lam K.S.L.
and Tan K.C.B.,
Dyslipidaemia and endothelial dysfunction n type 2
diabetes, 5th International Diabetes Federation
Western Pacific Region Congress. Beijing, May 2002.
PRC.
|
|
Lam K.S.L.
and Tan K.C.B.,
RENAAL: angiotensin II receptor antagonist and nephropathy
in type 2 diabetes, The First World Heart Foundation
Global Conference on Cardiovascular Clinical Trials,
Hong Kong November 2001. HK.
|
|
Lee K.K. and Tan
K.C.B., Androgen replacement therapy (review),
Medical Progress. 2002, 29(3): 26-30.
|
|
Tan K.C.B.,
Chow W.S., Ai V.H.G., Metz C., Bucala R. and Lam
K.S.L., Advanced glycation end products and endothelial
dysfunction in type 2 diabetes mellitus, Diabetes
Care. 2002, 25: 1055-1059 (A).
|
|
Tan K.C.B.,
Chow W.S., Tam
S.C.F., Ai V.H.G., Lam C.H.L. and Lam
K.S.L., Atorvastatin lowers C-reactive protein
and improves endothelial dysfunction in type 2 diabetes
mellitus, 2nd International Huaxia Congress of Endocrinology.
Hong Kong December, 2001. H.
|
|
Tan K.C.B.,
Cholesterol and body weight management, Journal
of Hong Kong Collage of Cardiology. 2002.
|
|
Tan K.C.B.,
Chow W.S., Wong
Y., Shiu S.W.M.
and Tam S.C.F.,
Effects of Angiotensin II Receptor Antagonist on Plasma
C-reactive Protein and Urinary Albumin Excretion in
Type 2 Diabetic Patients with Microalbuminuria, American
Diabetes Association 62nd Annual Meeting and Scientific
Sessions. San Francisco, June 2002. USA.
|
|
Tan K.C.B.,
Tso A.W.K., Pang
R.W.C. and Lam
K.S.L., Effects of Sandostatin LAR on lipoprotein
metabolism in patients with acromegaly - a six-month
prospective study, The Endocrine Society 83rd Annual
meeting. Denver, June 2001. 2002.
|
|
Tan K.C.B.,
Chow W.S., Ai V.H.G. and Lam
K.S.L., Effects of angiotensin II receptor antagonist
on endothelial vasomotor function and urinary albumin
excretion in type 2 diabetic patients with microalbuminuria,
Diabetes/Metabolism Research and Reviews. 2002,
18: 71-76.
|
|
Tan K.C.B.,
Shiu S.W.M.
and Chu B.Y.M., Effects of gender, hepatic lipase gene
polymorphism and type 2 diabetes mellitus on hepatic
lipase activity in Chinese, Atherosclerosis.
2001, 157: 233-239 (A)[2.89].
|
|
Tan K.C.B.,
Chow W.S., Ai V.H.G. and Lam
K.S.L., Effects of losartan on urinary albumin
excretion and endothelial vasomotor function in type
2 diabetic patients with microalbuminuria, 37th
Annual Meeting of the European Association for the
Study of Diabetes. Glasgow, September 2001. UK,
2002.
|
|
Tan K.C.B.,
Chow W.S., Ai V.H.G., Metz C., Bucala R. and Lam
K.S.L., Endothelial dysfunction and advanced glycation
end products in type 2 diabetes mellitus, 3rd Congress
of the Asia Pacific Society of Atherosclerosis and
Vascular Diseases. Cebu, February, 2002. Cebu.
|
|
Tan K.C.B.,
Shiu S.W.M.
and Wong Y.,
Glycaemic control is a major determinant of plasma
phospholipid transfer protein activity in patients
with type 2 diabetes mellitus, 5th International
Diabetes Federation Western Pacific Region Congress.
Beijing, May 2002. PRC.
|
|
Tan K.C.B.,
Chow W.S., O K.,
Ai V.H.G. and Lam
K.S.L., Hyperhomocysteinaemia and endothelial dysfunction
in patients with type 2 diabetes mellitus, The 5th
European Congress of Endocrinology. Turin, Italy. June
2001. Turin, Italy, 2002, June 2001.
|
|
Tsang K.W.T.,
Chan S., Leung R , Tan
K.C.B., Chan
H.H.L., Ho
J.C.S., Yan C., Ooi
C.G.C., Fung P.C. and Lam
W.K., Anti-inflammatory treatment increased exhaled
nitric oxide production on patients with active bronchiectasis.,
The Hong Kong Practitioner. 2002, 24(2): 59.
|
|
Leung J.C.K.,
Lan H.Y., Tang C.S.O.,
Chan D.T.M.
and Lai K.N.,
Polymeric IgA up-regulates macrophage migration inhibitory
factor (MIF) in human mesangial cell. [Abstract presented
at the Annual Meeting of the American Society of Nephrology,
Oct 10-17, 2001, San Francisco, USA], Journal of
the American Society of Nephrology. 2001, 12: 112A-113A.
|
|
Yu C.M., Chau M.C., Sanderson
J.E., Fan Y.Y.,
Tang M.O.,
Fung W.H., Lin
H., Kong S.L.,
Lam Y.M., Hill
M.R. and Lau C.P.,
Tissue Doppler echocardiographic evidence of reverse
remodeling and improved synchronicity by simultaneously
delaying regional contraction after biventricular pacing
therapy in heart failure., In: , Circulation.
2002, 105: 438-45.
|
|
Au W.Y., Lie A.K.W., Kwong Y.L., Shek T.W.H., Hawkins B.R., Lai K.N., Tang S.C.W.,
Lo C.M., Fan S.T., Liu
C.L., Chan
G.C.F., Chau
M.C., Chiu
S.W. and Liang
R.H.S., Post-transplantation lymphoproliferative
disease in Chinese: the Queen Mary Hospital experience
in Hong Kong, Leukemia and Lymphoma. 2002, 43:
1405-14September .
|
|
Choy C.B.Y.,
Lo W.K., Chan D.T.M., Lui S.L., Tang S.C.W.,
Lam M.F., Li F.K.
and Lai K.N.,
A randomised prospective comparison of intermittent
versus continuous dosing regimens of intraperitoneal
cefozolin and tobramycin in the treatment of CAPD preitonitis.
[Abstract presented at the Annual Meeting of the American
Society Nephrology, Oct 10-17, 2001, San Francisco,
USA], Journal of the American Society of Nephrology.
2001, 12: 425A.
|
|
Tang S.C.W.,
Human Kidney as an Organ of Complement Synthesis:
Its Regulation by Tubular Protein (Doctor of Medicine).
2001.
|
|
Tang S.C.W.,
Leung J.C.K.,
Lam C.W., Lam
M.F., Chan D.T.M.
and Lai K.N.,
In vitro studies of aquaporins 1 and 3 expression in
cultured human proximal tubular cells: upregulation
by transferrin but not albumin, American Journal
of Kidney Diseases. 2001, 38(2): 317-330.
|
|
Tang S.C.W.,
Leung J.C.K.,
Chan K.W., Chan Y.Y., Chan D.T.M. and
Lai K.N., Induction
of interleukin-8 in human proximal tubule cells: an
in vitro and in vivo study. [Abstract presented at
the Annual Meeting of the American Society of Nephrology,
Oct 10-17, 2001, San Francisco, USA], Journal of
the American Society of Nephrology. 2001, 12: 664A-665A.
|
|
Tang S.C.W.,
Kwok T.K., Ho P.L.,
Tang W.M., Chan
D.T.M. and Lai
K.N., Necrotizing fasciitis in a renal transplant
recipient treated with FK 506: the first reported case,
Clinical Nephrology. 2001, 56(6): 481-485.
|
|
Tang S.C.W.,
Lai K.N. and
Sacks S.H., Role of complement in tubulointerstitial
injury from proteinuria, Kidney Blood Pressure Research.
2002, 25(2): 120-126.
|
|
Tang S.C.W.,
Chan D.T.M.,
Li F.K., Choy C.B.Y., Tang
A., Ho Y.W. and Lai
K.N., Spousal renal donor transplantation in Chinese:
a ten-year experience from two regional hospitals in
Hong Kong. [Abstract presented at the European Dialysis
and Transplantation Association XXXIX Congress, July
14-17, 2002, Copenhagen, Denmark], Nephrology Dialysis
Transplantation. 2002, 17(Suppl 7): 320.
|
|
Fung F.M.Y.,
Wong W.M.,
Lam S.K., Yee
Y.K., Hung W.K., Yip W.C., Szeto M.L., Tong
S.M., Lai
K.C., Hu H.C.,
Hui C.K. and Wong
B.C.Y., Rabeprazole based 3-day and 7-day triple
therapy vs 7-day omeprazole based triple therapy for
the treatment of Helicobacter pylori infection, Journal
of Gastroenterology and Hepatology. 2001, 16
(9 suppl): A127.
|
|
Wong B.C.Y.,
Wong W.M.,
Yee Y.K., Hung W.K., Yip A.W., Seto M.L., Li K.F.,
Lau P., Fung F.M.Y.,
Tong S.M.,
Lai K.C., Hu H.C., Yuen
M.F., Hui C.K. and Lam
S.K., Rabeprazole-based 3-day and 7-day triple
therapy vs omeprazole-based 7-day triple therapy for
the treatment of Helicobacter pylori infection, Alimentary
Pharmacology and Therapeutics. 2001, 15(12):
1959-1965.
|
| Project Title: | Ciliary function in
childhood respiratory illnesses |
| Investigator(s): | Dr.
Tsang K.W.T. |
| Department: | Medicine |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | July 1997 |
| Abstract: |
| To examine the clinical significance of ciliary
function in children with respiratory diseases. |
| Project Title: | Taxotere study in
lung cancer |
| Investigator(s): | Dr.
Tsang K.W.T., Dr. Ho C.M., Prof. Ip M.S.M., Prof. Lam
W.K. |
| Department: | Medicine |
| Source(s) of Funding: | Rhone-Poulenc
Rorer Ltd. |
| Start Date: | August 1998 |
| Abstract: |
| Effects of treatment on non-small cell lung
cancer patients' (1) disease activity, (2) survival. |
| Project Title: | A systematic clinico-ultrastructural
correlation of the ciliary structure and function in
Chinese patients who suffer from bronchiectasis |
| Investigator(s): | Dr.
Tsang K.W.T., Prof. Ip M.S.M., Prof. Lam W.K., Dr.
Wong M.P. |
| Department: | Medicine |
| Source(s) of Funding: | Hong
Kong Research Grants Council Competitive Earmarked
Research Grants |
| Start Date: | September 1998 |
| Abstract: |
| To evaluate: (1) the function, orientation
and structure of respiratory cilia in bronchiectasis
and healthy control groups; (2) the disease severity
markers, demographic details, clinical features, lung
function indices, sputum microbiology, and aetiology
in the bronchiectasis group; (3) the correlation of
(1) and (2) and hence the prognostic, biological, and
clinical values of performing ciliary assessment in
bronchiectasis. |
| Project Title: | Bronchiectasis exacerbation
treatment study |
| Investigator(s): | Dr.
Tsang K.W.T., Prof. Ip M.S.M., Prof. Lam W.K. |
| Department: | Medicine |
| Source(s) of Funding: | Bristol-Myers-Squibb
(HK) |
| Start Date: | November 1998 |
| Abstract: |
| To compare the efficacy of cefepime vs ceftazidime
on exacerbations of bronchiectasis. |
| Project Title: | Fluticasone in bronchiectasis |
| Investigator(s): | Dr.
Tsang K.W.T., Prof. Ip M.S.M., Prof. Lam W.K. |
| Department: | Medicine |
| Source(s) of Funding: | Glaxo
Wellcome Hong Kong Ltd. |
| Start Date: | December 1998 |
| Abstract: |
| To determine the efficacy on (1) lung function,
(2) quality of life, (3) exacerbation frequency in
bronchectasis. |
| Project Title: | Traditional Chinese
medicine in the treatment of non-small cell lung cancer |
| Investigator(s): | Dr.
Tsang K.W.T. |
| Department: | Medicine |
| Source(s) of Funding: | The
Suen Chi Sun Charitable Foundation |
| Start Date: | August 1999 |
| Abstract: |
| To study traditional Chinese medicine in the
treatment of non-small cell lung cancer. |
| Project Title: | The effects of Helicobacter
pylori products on human respiratory mucosa in vitro |
| Investigator(s): | Dr.
Tsang K.W.T., Prof. Lam S.K., Prof. Lam W.K., Dr. Tipoe
G.L., Prof. Yuen K.Y., Dr. Zheng L. |
| Department: | Medicine |
| Source(s) of Funding: | Hong
Kong Research Grants Council Competitive Earmarked
Research Grants |
| Start Date: | December 2000 |
| Abstract: |
| To investigate the pathological role of H.pylori
in bronchiectasis. Results will help to re-conceptualize
the treatment of bronchiectasis. |
|
Chan L.Y.,
Fong D., Lam C.L., Chan
M.M.W., Say J.T.K., Leung
Y.H., Zheng L., Ooi
C.G.C., Ip
M.S.M., Lam
W.K. and Tsang
K.W.T., Validation of the Hong Kong Chinese
version of St Georges' Respiratory Questionnaire, The
Hong Kong Practitioner. 2002, 23 Suppl 2: 30.
|
|
Chiu D.C.S., Chiu
S.S.S., Chow
C.B., Ho P.L.,
Lau Y.L., Leung
C.W., Tsang D.N.C., Tsang
K.W.T., Tsang T.H.F., Wong
S.S.Y., Yang Y.H. and Yuen
K.Y., Proceedings of The First Current Topic in
Infectious Diseases: Consensus Meeting on Conjugate
Vaccines of the Center of Infection, Faculty of Medicine,
The University of Hong Kong, Hong Kong Journal of
Paediatrics (new series). 2001, 6: 127-132.
|
|
Ho J.C.M., Lam C.L., Ip S., Wong
M.P., Lam W.K.
and Tsang K.W.T.,
Exhaled nitric oxide predicts lung function but not
quality of life in subjects with non-small cell lung
cancer, Medical Research Conference, University
Department of Medicine, Hong Kong, 2002. The Hong
Kong Practitioner. 2002, 24 (2): 57 (C-RC-7).
|
|
Ho J.C.M., Chan K.N., Hu
H.C., Lam W.K.,
Zheng L., Tipoe
G.L., Sun J.Z.,
Leung Y.H.
and Tsang K.W.T.,
The effect of aging on nasal mucociliary clearance,
beat frequency and ultrastructure of respiratory cilia,
American
Journal of Respiratory and Critical Care Medicine.
2001, 163: 983-988.
|
|
Ho J.C.M., Hu H.C.,
Lam W.K., Chu L.W., Zheng
L., Tipoe G.L.,
Ooi C.G.C.,
Sun J.Z., Leung Y.H., Ip M.S.M., Chan M.M.W. and
Tsang K.W.T.,
The effect of aging on nasal mucociliary clearance,
beat frequency and ultrastructure of respiratory cilia,
Medical Research Conference, University Department
of Medicine, Hong Kong, 2001. The Hong Kong Practitioner.
2001, 23 (suppl 2): 66 (S-RM-5).
|
|
Hu H.C., Wong Y.H., Lai K.C., Hui
W.M., Lam K.F.,
Wong B.C.Y.,
Xia H.H.X.,
Chan C.K.,
Wong W.M.,
Tsang K.W.T.
and Lam S.K.,
Normal 24-hour ambulatory proximal and distal gastroesophageal
reflux parameters in Chinese, Hong Kong Medical
Journal. Hong Kong, Hong Kong Academy of Medicine
and the Medical Association, 2002, 8: 168-171.
|
|
Ip M.S.M.,
Lam B., Ng M.M.T.,
Lam W.K., Tsang K.W.T.
and Lam K.S.L.,
Hyperinsulinemia in obstructive sleep apnea, American
Thoracic Society International Conference, San Francisco,
USA, 2001. American Journal of Respiratory & Critical
Care Medicine. 2001, 163(5): A637.
|
|
Ip M.S.M.,
Tipoe G.L.,
Leung T.M.,
Zheng L., Shum D.K.Y.,
Tsang K.W.T.
and Lam W.K.,
Sputum sol in bronchiectasis stimulates IL-6 production
from bronchial epithelial cells, American Thoracic
Society International Conference, San Francisco, USA,
2001. American Journal of Respiratory & Critical Care
Medicine. 2001, 163(5): A467.
|
|
Lam B., Ooi C.G.C.,
Sam K., Lam W.K.,
Tsang K.W.T.
and Ip M.S.M.,
Upper airway change after oral appliance in obstructive
sleep apnoea patients - difference exist in good and
poor responders, Medical Research Conference, University
Department of Medicine, Hong Kong, 2001. The Hong Kong
Practitioner. 2001, 23(suppl 2): 27 (G-RM-6).
|
|
Lam C.L., Lam W.K.,
Ip T.Y., Ooi C.G.C., Lam
B., Ip S., Wang J., Ho J.C.M., Yan C., Chan
L.Y., Zheng L., Man
R.Y.K. and Tsang
K.W.T., Effects of herbal preparation, coriolus
versicolor Yun-Zhi, on non-small cell lung cancer (NSCLC),
Medical Research Conference, University Department
of Medicine, Hong Kong. 2001.
|
|
Lam C.L., Lam W.K.,
Yip T.C., Ooi C.G.C.,
Lam B., Ip S., Wang J., Ho J.C.M., Yan
C.P.K., Chan
L.Y., Zheng L., Man
R.Y.K. and Tsang
K.W.T., Effects of herbal preparation, corioulus
versicolor Yun-zhi, on non-small cell lung cancer (NSCLC),
Medical Research Conference, University Department
of Medicine, Hong Kong, 2001. The Hong Kong Practitioner.
2001, 23 (supp 2): 28 (G-RM-8).
|
|
Lam C.L., Lam W.K.,
Ho J.C.M., Yan
C.P.K., Chan S., Lam B., Zheng L., Ooi
C.G.C. and Tsang
K.W.T., Effects of yun-zhi on non-small cell
lung cancer (NSCLC), American Journal of Respiratory
Critical Care Medicine. 2001, 163(5): A67.
|
|
Lam C.L., Lam W.K.,
Wong M.P.,
Chung L.P., Ip
M.S.M., Tsang
K.W.T., Chau W.S., Suen W.S. and Chiu S.W.,
Establishment and application of primary lung cancer
cell lines (The HKULC Series) with local Chinese characteristics
in Hong Kong, Joint Annual Scientific Meeting, Hong
Kong Thoracic Society, Chinese Thoracic Society and
American College of Chest Physicians, Hong Kong. 2002.
Abstract pp.26.
|
|
Lam C.L., Lam W.K.,
Ip M.S.M.,
Tsang K.W.T.,
Lam B., Yan C.P.K.,
Ho J.C.M., Ip S. and Wong M.K.Y., The combined use
of gemcitabine and ifosfamide in patients with Stage
III or IV non-small cell lung cancer (NSCLC), Medical
Research Conference, University Department of Medicine,
Hong Kong, 2002. The Hong Kong Practitioner. 2002,
24(2): 55 (C-RC-3).
|
|
Lam C.L., Lam W.K.,
Ip M.S.M.,
Tsang K.W.T.,
Lam B., Ho J.C.M., Ip S. and Wang J.K.L., The use of
gemcitabine and cisplatin in Chinese patients with
advanced non-small cell lung carcinoma (NSCLC), Medical
Research Conference, University Department of Medicne,
Hong Kong, 2001. The Hong Kong Practitoner. 2001,
23(suppl 2): 24(G-RM-1).
|
|
Ooi C.G.C.,
Ho JCM , Khong P.L., Lam
W.K. and Tsang
K.W.T., CT features of advanced primary pulmonary
lymphoepithelioma-like carcinoma (LELC), UK Radiological
Congress, Birmingham, UK, 2002.. 2002, 481.
|
|
Ooi C.G.C.,
Chan P.K., Lee J.C., Fok C.Y., Ho J.C.M., Lam B., Lam W.K. and Tsang K.W.T.,
HRCT quantification of bronchiectasis : a functional-morphologic
study, Medical Research Conference, University Department
of Medicine, Hong Kong, 2001.The Hong Kong Practitioner.
2001, 23 (suppl 2): 28 (G-RM-9).
|
|
Ooi C.G.C.,
Khong P.L.
and Tsang K.W.T.,
HRCT quantification of bronchiectasis with clinico-functional
correlation., 9th Annual Scientific Meeting, Hong
Kong College of Radiologists. 2001.
|
|
Ooi C.G.C.,
Chan P.K., Lee J.C., Fok C.Y., Lam
W.K. and Tsang
K.W.T., High resolution computed tomography
quantification of bronchiectasis with functional-morphologic
correlation, American Journal of Respiratory Critical
Care Medicine. 2001, 163(5): A85.
|
|
Ooi C.G.C.,
Tan B.B.S., Tsang F.C.P., Lee I.Y.C., Khong
P.L., Tsang
K.W.T. and Chan
F.L., Lymph node density in silicosis: its relationship
with lung function and clinical parameters., 9th
Annual Scientific Meeting, Hong Kong College of Radiologists.
2001.
|
|
Ooi C.G.C.,
Tan B.B.S., Tsang C.P., Lee I.Y.C., Leung K., Khong
P.L., Tsang
K.W.T. and Lam
W.K., Lymph node density in silicosis: its relationship
with lung function and clinical parameters., The
Hong Kong Practitioner. 2002, 24(2): 56.
|
|
Ooi C.G.C.,
Cheng R.S., Lam V.S., Fok C.Y., Ngan
H.Y.S., Lam
W.K. and Tsang
K.W.T., Mediastinal nodal calcification pattern
on computed tomography in silicosis, American Journal
of Respiratory Critical Care Medicine. 2001, 163(5):
A168.
|
|
Ooi C.G.C.,
Kwong D.L.W.,
Ho J.C.M., Lock D.T., Chan
F.L., Lam W.K.,
Ngan H.Y.S.,
Au G.K.H. and
Tsang K.W.T.,
Pulmonary sequalae of treatment for breast cancer :
a perspective study, International
Journal of Radiation Oncology, Biology, Physics.
2001, 50: 411-419.
|
|
Ooi C.G.C.,
Khong P.L.,
Chan-Yeung M., Ho J.C.M., Lam
W.K. and Tsang
K.W.T., The utility of HRCT in bronchiectasis:
a clinico-functional correlative study, European
Congress of Radiology, Vienna, Austria, 1-5 March 2002.
|
|
Shum H.Y.I.,
Zheng L., Taylor G., Lam
W.K., Fung P.C.W.,
Leung Y.H.,
Sun J.Z., Tipoe G.L. and
Tsang K.W.T.,
Pseudomonas aeruginosa 1-hycroxyphenazine stimulates
iNOS expression in human respiratory mucosa, American
Journal of Respiratory and Critical Care Medicine.
2001, 163(5): A670.
|
|
Shum H.Y.I.,
Zheng L., Taylor G., Sun
J.Z., Tipoe
G.L., Ho J.C.M., Fung
P.C.W., Lam
W.K. and Tsang
K.W.T., Upregulation of iNOS expression in
human respiratory mucosa by Pseudomonas aeruginosa
1-hydroxyphenazine, The Hong Kong Practitioner.
2001, 23(Suppl 2): 66.
|
|
Tsang K.W.T.,
Chan S., Leung R , Tan
K.C.B., Chan
H.H.L., Ho
J.C.S., Yan C., Ooi
C.G.C., Fung P.C. and Lam
W.K., Anti-inflammatory treatment increased exhaled
nitric oxide production on patients with active bronchiectasis.,
The Hong Kong Practitioner. 2002, 24(2): 59.
|
|
Tsang K.W.T.,
Leung J.C., Tipoe
G.L., Leung R., Yan C., Ooi
C.G.C., Chan
H.H.L., Fung
P.C.W., Lam
W.K. and Lai
K.N., Aquaporin 3 expression in respiratory mucosa
is down-regulated in bronchiectasis in vivo., The
Hong Kong Practitioner. 2002, 24(2): 58.
|
|
Tsang K.W.T.,
Leung J.C., Tipoe
G.L., Leung R., Yan C., Ooi
C.G.C., Chan
H.H.L., Fung
P.C.W., Lam
W.K. and Lai
K.N., Aquaporin 3 expression in respiratory mucosa
is down-regulated in bronchiectasis in vivo, The
Hong Kong Practitioner. 2002, 24: C-RC-8.
|
|
Tsang K.W.T.,
Kinoshita R., Rouke N., Yuen q., Hu
H.C. and Lam
W.K., Bronchoscopy of cetaceans, Journal of
Wildlife Diseases. 2002, 38(1): 224-227.
|
|
Tsang K.W.T.,
Lam C.L., Ho J.C.M., Lam B., Chan
L.Y., Man R.Y.K.,
Sham J.S.T.
and Lam W.K.,
Coriolus versicolor Yun-Zhi could delay deterioration
of patients with advanced non-small cell lung cancer,
The Hong Kong Practitioner. 2002, 24(2) Suppl:
59.
|
|
Tsang K.W.T.,
Ip S.K., Leung R., Tipoe G.L., Chan S.L., Shum I.H.,
Ip M.S.M.,
Yan C., Fung P.C., Chan
M.M.W. and Lam
W.K., Enhaled nitric oxide: the effects of age,
gender and body size, Lung.
2001, 179(2): 83-91.
|
|
Tsang K.W.T.,
Ip S.K., Leung R., Tipoe
G.L., Chan S.L., Shum I.H., Ip
M.S.M., Yan C., Fung
P.C.W., Chan-Yeung M. and Lam W., Exhaled nitric
oxide: The effects of age, gender and body size, Lung.
2001, 179: 83-91.
|
|
Tsang K.W.T.,
Lam B., Ooi C.G.C.,
Ho J.C.S.,
Chan S., Yan C., Leung R., Ip
M.S.M., Chan
M.M.W. and Lam
W.K., Inhaled fluticasone therapy reduces exacerbation
frequency and sputum production in bronchiectasis (BX).,
The Hong Kong Practitioner. 2002, 24(2): 58.
|
|
Tsang K.W.T.,
Solutions for difficult diagnostic cases of acute exacerbations
of chronic bronchitis, Chemotherapy. 2001, 47(Suppl
4): 28-38.
|
|
Tsang K.W.T.,
Treatment of bronchiectasis, Journal of Japanese
Respiratory Society. 2002, 40 Suppl: 36.
|
|
Wang J.K.L., Lam
W.K., Ho J.C.M., Ip
M.S.M. and Tsang
K.W.T., Paclitaxel and carboplatin in advanced
non-small cell lung cancer (NSCLC), Hong Kong experience,
Medical Research Conference, University Department
of Medicine, Hong Kong, 2001. The Hong Kong Practitioner.
2001, 23(suppl 2): 25 (G-RM-3).
|
|
Wong M., Chan S., Yan C., Chan
M.M.W., Ho
J.C.S., Lam B., Ooi
C.G.C., Ip
M.S.M., Lam
W.K. and Tsang
K.W.T., Inhaled steroid therapy is associated
with improvement in quality of life among bronchiectasis
patients., The Hong Kong Practitioner. 2002,
24(2): 60.
|
|
Zheng L., Lam W.K.,
Shum H.Y.I.,
Tipoe G.L.,
Yan C.P.K.,
Leung Y.H.,
Sun J.Z., Ooi C.G.C., Ip M.S.M. and
Tsang K.W.T.,
Expression of matric matelloproteinase-8 and 9 is raised
in the airways of patients with bronchiectasis in vivo,
The Hong Kong Practitioner. 2001, 23(Suppl 2):
64.
|
|
Zheng L., Lam W.K.,
Shum H.Y.I.,
Tipoe G.L.,
Yan C.P.K.,
Leung Y.H.,
Sun J.Z., Ooi C.G.C., Ip M.S.M. and
Tsang K.W.T.,
Over expression of matrix metalloproteinase-8 (MMP-8)
and -9 (MMP-9) in bronchiectatic airways in vivo, Medical
Research Conference, University Department of Medicine,
Hong Kong, 2001. The Hong Kong Practitioner. 2001,
23 (suppl 2): 64 (S-RM-1).
|
|
Zheng L., Lam W.K.,
Tipoe G.L.,
Shum H.Y.I.,
Yan C.P.K.,
Leung Y.H.,
Sun J.Z., Ooi C.G.C. and
Tsang K.W.T.,
Overexpression of matrix metalloporteinase-8 and -9
in bronchiectatic airways in vivo, European Respiratory
Journal. 2002, 20: 170-176.
|
|
Zheng L., Shum
H.Y.I., Lam
W.K., Tipoe
G.L., Yan C.P.K.,
Ooi C.G.C.,
Ho J.C.M., Fung
P.C.W., Ip
M.S.M. and Tsang
K.W.T., Overexpression of matrix metalloproteinase-8
(MMP-8) and-9 in bronchiectatic airways in vivo, American
Journal of Respiratiry and Critical Care Medicine.
2001, 163(5): A671.
|
|
Tse E.Y.Y.,
Lee K.L.F.
and Lau C.P.,
Adenosine triphosphate enhanced contrast pulmonary
venogram to facilitate pulmonary vein ablation., J
Cardiovasc Electrophysiol. 2002, 13: 300.
|
| Project Title: | Effects of changes
in site of atrial pacing and the atrioventricular interval
during dual chamber pacing on atrial electrophysiological
and mechanical properties in human |
| Investigator(s): | Dr.
Tse H.F., Prof. Lau C.P. |
| Department: | Medicine |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | November 2000 |
| Abstract: |
| To assess the effect of changes in atrial pacing
site and AV interval on atrial electrophysiology and
vulnerability for atrial fibrillation. |
| Project Title: | Prevention of cardiomyocyte
apoptosis and myocardial fibrosis by neovascularization
of ischemic myocardium by autologous bone marrow cells
transplantation |
| Investigator(s): | Dr.
Tse H.F., Prof. Kwong Y.L., Prof. Lau C.P., Dr. Nicholls
J.M. |
| Department: | Medicine |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | November 2001 |
| Abstract: |
| To evaluate the effect of inducing neovascularization
by using bone marrow stem cells on cardiomyocyte apoptosis,
collagen deposition and myocardial function, in animal
model of chronic myocardial ischemia. |
|
Lau C.P., Tse H.F.,
Ng W., Chan K.K., Li S.K., Keung K.K., Lau Y.K., Chen W.H., Tang
Y.W. and Leung S.K., Comparison of perindopril versus
captopril for treatment of acute myocardial infarction.,
Am J Cardiol. 2002, 89: 150-154.
|
|
Lau C.P., Tse H.F.,
Yu C.M., Teo
W.S., Kam R., Ng K.S., Huang S.S., Lin J.L., Fitts
S.M., Hettrick D.A. and Hill M.R., Dual-site atrial
pacing for atrial fibrillation in patients without
bradycardia., Am J Cardiol. 2001, 88: 371-5.
|
|
Lau C.P. and
Tse H.F.,
Early reinitiation of atrial fibrillation after electrical
defibrillation: a new electrphysiological phenomenon.,
Pacing and Clinical Electrophysiology. 2001,
24: 1581-1584.
|
|
Tse H.F.
and Lau C.P.,
Advance in internal and external cardioversion., In:
Israel CW, Barold SS, Advances in the Treatment
of Atrial Tachyarrhythmias: Pacing, Cardioversion,
and Defibillation. Armonk, NY, Futura Publising
Co Inc, 2002, 419-435.
|
|
Tse H.F.,
Oral H., Pelosi F., Knight B.P., Strickberger S.A.
and Morady F., Effect of gender on atrial electrophysiologic
changes induced by rapid atrial pacing and elevation
of atrial pressure, Journal of Cardiovascular Electrophysiology.
2001, 12: 986-9.
|
|
Tse H.F.,
Wang Q., Yu C.M.,
Ayers G. and Lau
C.P., Effect of verapamil on prevention of atrial
fibrillation in patients implanted with an implantable
atrial defibrillator, Clin. Cardiol. 2001, 24(7):
503-505.
|
|
Tse H.F.,
Lau C.P., Rodriguez
L.M., Timmermans C., Daoud E.G., Ayers G.M. and Wellens
H.J., Effects of coexisting cardiovascular disease
on the long-term efficacy and safety of the implantable
atrial defibrillator, Pacing Clin Electrophysiol.
2002, 25: 8September -15.
|
|
Tse H.F.
and Lam W.F., JTV-519 Japan Tobacco, Current Opinion
in Investigating Drugs. 2001, 2: 936-9.
|
|
Tse H.F.,
Lee K.L.F.,
Fan Y.Y. and
Lau C.P., Nonfluoroscopic
magnetic electroanatomic mapping to facilitate focal
pulmonary viens ablation for paroxysmal atrial fibrillation.,
Pacing Clin Electrophysiol. 2002, 25: 57-61.
|
|
Xu W.,
Tse H.F.,
Chan F.H.Y.,
Fung P.C.W.,
Lee K.L.F.
and Lau C.P.,
New Bayesian discriminator for detection of atrial
tachyarrhythmias, Circulation
(Journal of the American Heart Association). Philadelphia,
USA, LWW, 2002, 105 (Issue 12): 1472-1479.
|
|
Yu C.M., Tse H.F.,
Chau M.C.,
Fan Y.Y., Lee K.L.F., Leung
S.K., Wan S.H. and Lau
C.P., 雙心室起搏治療心力衰竭的初步經驗, In: , 中華心律失常學雜誌, 2002,
4.
|
|
Jiang X., Lam S.K., Tu S., Lin M.C., Kung
H. and Wong
B.C.Y., Specific COX-2 inhibitor suppresses anchorage-independent
cell growth through AP-1/MAPK pathway in gastric cancer
(oral presentation), Gastroenterology. 2002,
122(4 Suppl 1).
|
|
Chen C.N.S., Ho
D.S.W., Zhang R., Wang
Y., Santoso T. and Lim Y.L., Long Diffuse Coronary
Lesions, Course book of The Paris Course on Revascularization,
Paris. 2002.
|
|
Ho D.S.W.,
Zhang R.Y., Waser M., Shen Z.J., Wang
Y. and Ouyang P., ChoICETM
PT Wire for Recanalization of Chronically Occluded
Coronary Arteries: Multiple Wires in One?, The Journal
of Invasive Cardiology. 2002.
|
|
Cheung B.M.Y.,
Lo L.F., Lam T.H., Lam
K.S.L., Lau
C.P., Tam S.C.F.,
Wat N.M.S.,
Man Y.B. and
Cheng C.H., Follow up of the Hong Kong cardiovascular
risk factor prevalence survey cohort, J HK Coll
Cardiol. 2002, 10 (Supple): 129.
|
|
Cheung B.M.Y.,
Lo L.F., Lam T.H., Lam
K.S.L., Lau
C.P., Tam S.C.F.,
Wat N.M.S.,
Man Y.B. and
Cheng C.H., Six year follow up of the Hong Kong cardiovascular
risk factor prevalence survey cohort, Cardiovascular
Drugs Therapeutics. 2002, 16(Supple 1): 26-27.
|
|
Ng E.H.Y.,
Wat N.M.S.
and Ho P.C.,
Effects of metformin on ovulation rate, hormonal and
metabolic profiles in women with clomiphene resistant
polycystic ovaries: A randomized, double-blinded placebo-controlled
trial, Gynecological Endocrinology. 2001, 15
(Supplement 5): 91.
|
|
Wat N.M.S.,
Lam T.H., Janus
E.D. and Lam K.S.L.,
Central obesity predicts the worsening of glycemia
in southern Chinese, International Journal of Obesity.
2001, 25: 1789-93.
|
|
Chim J.C.S.,
Liang R.H.S.,
Wong A.S.Y.
and Kwong Y.L.,
Methylation profiling in acute leukaemia., American
Association for Cancer Research Satellite Meeting on
cancer and chromosomal organization : Epigenetics of
Cancer. San Francisco, USA.. 2001.
|
| Project Title: | The role of free radicals
in peptic ulcer and gastric cancer |
| Investigator(s): | Dr.
Wong B.C.Y., Prof. Fung P.C.W., Prof. Lam S.K. |
| Department: | Medicine |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | July 1998 |
| Abstract: |
| To study the role of nitric oxide in the pathogenesis
of gastric diseases; to study the clinical and in vivo
detection of nitric oxide or other free radicals in
human gastric sytsem; to screen for and monitor new
potential pharmacological agents on modification of
free radical production. |
| Project Title: | Induction of apoptosis
by selective protein kinase C-Beta and cyclooxygenase-2
inhibition: novel target for gastric cancer treatment |
| Investigator(s): | Dr.
Wong B.C.Y., Prof. King G.L. |
| Department: | Medicine |
| Source(s) of Funding: | Hong
Kong Research Grants Council Competitive Earmarked
Research Grants |
| Start Date: | September 1999 |
| Completion Date: | August 2002 |
| Abstract: |
| To study the role of protein kinase C (PKC)
and nonsteroidal antiinflammatory drugs (NSAID) in
apoptosis of gastric cancer; to investigate in depth
the role of PKC in gastric carcinogenesis and possible
target for intervention. |
| Project Title: | Molecular basis of
the anti-tumor activities of specific cyclooxygenase-2
inhibitors |
| Investigator(s): | Dr.
Wong B.C.Y., Prof. Kung H.F., Prof. Lam S.K., Dr. Lin
M.C.M. |
| Department: | Medicine |
| Source(s) of Funding: | Hong
Kong Research Grants Council Competitive Earmarked
Research Grants |
| Start Date: | September /2001 |
| Abstract: |
| To determine the signaling pathways leading
to SC236-induced apoptosis in gastric cancer cells;
to elucidate the molecular mechanisms leading to the
inhibitions of NF-kB and AP-1 activations; to test
the effect of SC236 in tumor transformation in JB6
mouse epidermal cells; to test the in vivo effect of
COX-2 inhibition on gastric cancer in nude mice and
COX-2 knockout mice. |
|
Chan A.O.O., Wong
B.C.Y. and Lam
S.K., Gastric cancer: past, present and future,
Can J Gastroenterol. 2001, 15(7): 469-474.
|
|
Fan X.M., Wong
B.C.Y., Zhou X.M., Wang W.P., Lin
M.C., Kung
H., Yuen S.T., Leung
S.Y. and Lam
S.K., Inhibition of proteasome function induced
apoptosis in gastric cancer cells, International
Journal of Cancer. 2001, 93(4): 481-8.
|
|
Feng Z.H., Guan
X.Y., Ho S.L.,
Sham J.S.T.
and Wong B.C.Y.,
P53 status determines nuclear factor-kapa B response
in Triptolide-induced apoptosis in gastric cancer.
Poster presentation at the 92nd Annual Meeting of
the American Association of Cancer Research, Proceedings
of American Association of Cancer Research Annual Association
of Cancer Research Annual Meeting. 2001, 42: 659.
|
|
Fung F.M.Y.,
Wong W.M.,
Lam S.K., Yee
Y.K., Hung W.K., Yip W.C., Szeto M.L., Tong
S.M., Lai K.C.,
Hu H.C., Hui
C.K. and Wong
B.C.Y., Rabeprazole based 3-day and 7-day triple
therapy vs 7-day omeprazole based triple therapy for
the treatment of Helicobacter pylori infection, Journal
of Gastroenterology and Hepatology. 2001, 16
(9 suppl): A127.
|
|
Gu Q., Wong
W.M., Lam S.K.,
Yin Y., Wang W.H., Fung
F.M.Y., Lai
K.C., Xia H.H.X.,
Wong B.C.Y.
and Xiao S.D., One week omeprazole, furazolidone and
amoxycillin rescue therapy after failure of Helicobacter
pylori eradication with standard triple therapies,
Gastroenterology.
2002, 122 (4 suppl 1): A586.
|
|
Hu H.C., Wong Y.H., Lai K.C., Hui
W.M., Lam K.F.,
Wong B.C.Y.,
Xia H.H.X.,
Chan C.K.,
Wong W.M.,
Tsang K.W.T.
and Lam S.K.,
Normal 24-hour ambulatory proximal and distal gastroesophageal
reflux parameters in Chinese, Hong Kong Medical
Journal. Hong Kong, Hong Kong Academy of Medicine
and the Medical Association, 2002, 8: 168-171.
|
|
Hu H.C., Lam K.F., Wong
Y.H., Lam C.L.K.,
Hui W.M., Lai K.C., Wong B.C.Y.
and Lam S.K.,
The Hong Kong index of dyspepsia: A validated symptom
severity questionnaire for patients with dyspepsia,
Journal
of Gastroenterology and Hepatology. Melbourne,
Australia, Blackwell Science, 2002, 17: 545-551.
|
|
Huang J., Lin M.C., Bai
Y.X., Jing D.D., Wong
B.C.Y., Han S.W., Lin J., Xu B., Huang C.F.
and Kung H.,
Ectopic expression of a C-terminal fragment of the
human telomerase reverse transcriptase leads to telomere
dysfunction and reduction of growth and tumorigenicity
in HeLa cells, Cancer
Research. 2002, 62: 3226-3232.
|
|
Huang X.R., Chun Hui C.W., Chen Y.X., Wong
B.C.Y., Fung
P.C.W., Metz C., Cho
C.H., Hui W.M.,
Bucala R., Lam S.K.,
Lan H.Y., Chun
B. and Wong Y., Macrophage migration inhibitory factor
is an important mediator in the pathoenesis of gastric
inflammation in rats, Gastroenterology. 2001,
121(3): 619-630.
|
|
Huang X.i.a.o. .R.u., Hui C.o.n.n.i.e. .W. .C., Chen
Y.o.n.g. .X.i.o.n.g., Wong
B.C.Y., Fung
P.C.W., Metz C.h.r.i.s.t.i.n.e., Cho C.h.i.n. .H.i.n.,
Hui W.a.i. .M.o., Bucala R.i.c.h.a.r.d., Lam
S.K. and Lan H.u.i. .Y., Macrophage Migration Inhibitory
Factor is an Important Mediator in the Pathogenesis
of Gastric Inflammation, Gastroenterology.
2002, 121: 619-630.
|
|
Jiang X., Lam S.K., Fan X.M.,
Lin M.C., Kung H. and Wong B.C.Y.,
Specific COX-2 inhibitor suppresses NF-kB activation
by inhibition of RelA/p65 nuclear translocation in
gastric cancer, Gastroenterology. 2002, 122(4
Suppl 1): A240.
|
|
Jiang X., Lam S.K., Tu
S., Lin M.C.,
Kung H. and
Wong B.C.Y.,
Specific COX-2 inhibitor suppresses anchorage-independent
cell growth through AP-1/MAPK pathway in gastric cancer
(oral presentation), Gastroenterology. 2002,
122(4 Suppl 1).
|
|
Lai K.C., Lam S.K., Chu
K.M., Wong
B.C.Y., Hui
W.M., Hu H.C.,
Lau G., Wong W.M., Yuen M.F., Chan
A.O.O., Lai C.L.
and Wong J.,
Lansoprazole for the prevention of recurrences of ulcer
complications from long-term low-dose aspirin use,
New
England Journal of Medicine. 2002, 346(26):
2033-2038.
|
|
Ng F.H., Wong W.M.,
Wong B.C.Y.,
Kng C., Wong S.Y., Lai
K.C., Cheng C.S., Yuen W.C., Lam
S.K. and Lai
C.L., Sequential intravenous/oral antibiotic vs.
continuous intravenous antibiotic in the treatment
of pyogenic liver abscess., Alimentary
Pharmacology and Therapeutics. 2002, 16(6):
1083-1September 0.
|
|
Wong B.C.Y.,
Jiang X.
and Lam S.K.,
Cyclooxygenase and gastric cancer, Journal of Modern
Digestion and Intervention. 2001, 6 (6): 23-25.
|
|
Wong B.C.Y.,
Gu Q. and Lam S.M., Diagnosis
and treatment of Helicobacter pylori infection in Hong
Kong, Helicobacter pylori infection: basic and clinical
aspects. Chinese Science and Technology Press,
2002, 449-455.
|
|
Wong B.C.Y.
and Wu J.,
Different approaches of incorporating TCM in treatment
of gastrointestinal diseases, Proceedings, TWGHs-HKU
Eddie Wang Chinese Medicine Symposium, 2-3 February.
2002, 47.
|
|
Wong B.C.Y.
and Wu J.,
Different approaches of incorporating traditional Chinese
medicine in the treatment of gastrointestinal diseases,
Proceedings, Symposium in Medical Sciences, 21st
Century Health Care in Hong Kong, A new era, 1-2 June.
2002.
|
|
Wong B.C.Y.,
Yin Y., Berg D.E., Xia
H.H.X., Zhang J.Z., Wang W.H., Wong
B.C.Y., Huang X.R., Tang V.S. and Lam
S.K., Distribution of distinct vacA, cagA and iceA
alleles in Helicobacter pylori in Hong Kong, Helicobacter.
2001, 6(4): 317-324.
|
|
Wong B.C.Y.,
Wang W.P., So H.L.,
Shin V.Y.,
Wong W.M.,
Fung F.M.Y.,
Liu E.S.L.,
Hui W.M., Lam S.K. and Cho C.H., Epidermal
growth factor and its receptor in chronic active gastritis
and gastroduodenal ulcer before and after Helicobacter
pylori eradication, Alimentary
Pharmacology and Therapeutics. 2001, 15(9):
1459-1465.
|
|
Wong B.C.Y.,
Lam S.K., Wong W.M., Zheng T., Chen
J.S., Chen B.W., Lai
K.C., Yuen
S.T. and Ho
J.C.Y., Eradicating Helicobacter pylori infection
in general population prevents gastric cancer: 1 7
year prospective randomized placebo-controlled study,
Gstroenterology.
2002, 122 (4 suppl 1): A588.
|
|
Wong B.C.Y.,
Lam S.K., Wong W.M., Feng
R.E., Zheng T.,
Yuen S.T.,
Ho J.C.Y., Leung S.Y., Chen
J.S. and Lai K.C.,
Eradication of Helicobacter pylori infection significantly
slows down the progression of precancerous lesions
in high risk population: a 5-year prospective randomized
study, Gastroenterology.
2002, 122 (4 suppl 1): A588.
|
|
Wong B.C.Y.,
Latest development in the management of acid-related
diseases, HKMA CME Bulletin. 2001, 12: 22-23.
|
|
Wong B.C.Y.,
Wong W.M.,
Yee Y.K., Hung W.K., Yip A.W., Seto M.L., Li K.F.,
Lau P., Fung F.M.Y.,
Tong S.M.,
Lai K.C., Hu H.C., Yuen
M.F., Hui C.K. and Lam
S.K., Rabeprazole-based 3-day and 7-day triple
therapy vs omeprazole-based 7-day triple therapy for
the treatment of Helicobacter pylori infection, Alimentary
Pharmacology and Therapeutics. 2001, 15(12):
1959-1965.
|
|
Wong B.C.Y.,
Jiang X.
and Lam S.K.,
Role of cyclooxygenase-2 and gastric cancer. (in Chinese),
Journal of Modern Digestion and Intervention.
2002, 7(5): 69-70.
|
|
Wong B.C.Y.,
Wang W.H., Wong W.M., Lau
G., Fung F.M.Y., Kung N.N.S., Chu
K.M., Lai K.C., Hu W.H.C., Hu F.L., Liu X.G., Chan
C.K., Yuen M.F., Hui
W.M. and Lam
S.K., Three-day Lansoprazole quadruple therapy
for Helicobacter pylori-positive duodenal ulcers: a
randomized controlled study, Alimentary
Pharmcology and Therapeutics. 2001, 15: 843-850.
|
|
Wong W.M.,
Wong B.C.Y.,
Xia H.H.X.,
Tang V.S., Lai
K.C., Hu H.C.,
Yuen M.F.,
Chan C.K. and
Lam S.K., An
evaluation of a rapid urine test for the diagnosis
of Helicobacter pylori infection in the Chinese population,
Alimentary
Pharmacology and Therapeutics. 2002, 16(4):
813-817.
|
|
Wong W.M.,
Wong B.C.Y.,
Tang V.S.Y., Wong K.W., Li T.M., Cheung K.L., Fung
F.M.Y., Lai
K.C., Hu H.C.,
Chan C.K.,
Xia H.H.X.
and Lam S.K.,
Evaluation of three near patient tests for the diagnosis
of Helicobacter pylori infectino in Chinese population,
The
Hong Kong Practitioner. 2002, 24 (2 suppl):
43.
|
|
Wong W.M.,
Mandir N., Goodlad R.A., Wong
B.C.Y., Garcia S.B., Lam
S.K. and Wright A., Histogenesis of human colorectal
adenomas and hyperplastic polyps: the role of cell
proliferation and crypt fission, Gut.
2002, 50(2): 212-217.
|
|
Wong W.M.,
Wong B.C.Y.,
Lu H., Gu Q.,
Yin Y., Wang W.H., Fung
F.M.Y., Lai
K.C., Xia H.H.X.,
Xiao D. and Lam
S.K., One-week omeprazole, furazolidone and amoxicillin
rescue therapy after failure of Helicobacter pylori
eradication with standard triple therapies, Alimentary
Pharmacology and Therapeutics. 2002, 16(4):
793-798.
|
|
Wong W.M.,
Gu Q., Lam
S.K., Fung
F.M.Y., Lai
K.C., Xia H.H.X.,
Hu H.C. and
Wong B.C.Y.,
Randomized controlled trial of rabeprazole, levofloxacin
and rifabutin triple therapy versus rabeprazole-based
quadruple therapy as a rescue treatment for failure
of Helicobacter pylori eradication with standard tiple
therapies, Gastroenterology.
2002, 122 (4 suppl 1): A587.
|
|
Wong W.M.,
Lai K.C., Lau C.P., Hu
H.C., Chen
W.H., Wong
B.C.Y., Hui
W.M., Wong
Y.H., Xia H.H.X.
and Lam S.K.,
Upper gastrointestinal evaluation of Chinese Patients
with non-cardiac chest pain, Alimentary
Pharmacology and Therapeutics. 2002, 16(3):
465-471.
|
|
Wong W.M.,
Lai K.C., Lau C.P., Hu
H.C., Chen
W.H., Wong
B.C.Y., Hui
W.M., Wong
Y.H., Xia H.H.X.
and Lam S.K.,
Upper gastrointestinal evaluation of Chinese patients
with noncardiac chest pain, The
Hong Kong Practitioner. 2002, 24 (2 suppl):
44.
|
|
Xia H.H.X.,
Wong B.C.Y.,
Wong K.W., Wong S.Y., Wong
W.M., Lai K.C.,
Hu H.C., Chan C.K. and
Lam S.K., Clinical
and endoscopic characteristics of non-Helicobacter
pylori, non-NSAID duodenal ulcers: a long-term prospective
study, Alimentary
Pharmacology and Therapeutics. 2001, 15(12):
1875-1882.
|
|
Xia H.H.X.,
Wong B.C.Y.,
Huang X.R., He X.X., Wong
W.M., Leung
S.Y., Yuen
S.T., Lan H.Y.
and Lam S.K.,
Expression of macrophage migration inhibitory factor
in Helicobacter pylori induced gastritis and peptic
ulcer disease, The
Hong Kong Practitioner. 2002, 24 (2 suppl):
41.
|
|
Xia H.H.X.,
Wong B.C.Y.
and Lam S.K.,
Helicobacter pylori infection and gastroduodenal muscosal
damage and healing, Gastrointestinal mucosal repair
and experimental therapeutics. Front Gastrointest
Res. Switzerland, S Karger AG, 2002, 143-157.
|
|
Xia H.H.X.,
Wong B.C.Y.,
Wong W.M.,
Tang V.S., Cheung H.K., Sham F.N., Fung
F.M.Y., Lai
K.C., Hu H.C.,
Chan C.K. and
Lam S.K., Optimal
serological tests for the detection of Helicobacter
pylori infection in the Chinese population, Alimentary
Pharmacology and Therapeutics. 2002, 16(3):
521-526.
|
|
Zhang H.B., Wong
B.C.Y., Zhou X.M., Guo X.G., Zhao S.J., Wang
J.H., Wu K.C., Ding J., Lam
S.K. and Fan D.M., Effects of somatostatin, octreotide
and pitressin plus nitofglycerine on systemic and protal
haemodynamics in the control of acute variceal bleeding,
International Journal of Clinical Practice.
2002, 56(6).
|
|
Chan D.T.M.,
Wong R.W.S.,
Lau W.C.S.,
Tsang E.W.K., Ji Y.L., Mok M.Y., Tong M.K.L., Wong
A.K.M. and Lai K.N.,
Prolonged follow-up of patients with diffuse proliferative
lupus nephritis (DPLN) treated with prednisolone and
mycophenolate mofetil (MMF). [Abstract presented at
the Annual Meting of the American Society of Nephrology,
Oct 10-17, 2001, San Francisco, USA], Journal of
the American Society of Nephrolgoy. 2001, 12: 195A.
|
|
Mok C.C., Lau W.C.S.
and Wong R.W.S.,
Neuropsychiatric manifestations and their clinical
associations in Southern Chinese patients with systemic
lupus erythematosus, Journal of Rheumatology.
2001, 28(4): 766-771.
|
|
Mok C.C., Ho C.T.K.,
Chan W.K.,
Lau W.C.S.
and Wong R.W.S.,
Outcome and prognostic indicators of diffuse proliferative
lupus glomerulonephritis (SLE-DPGN) treated with sequential
oral cyclophosphamide (CYC) and azathioprine (AZA),
Arthritis & Rheumatism. 2001, 44(9 Supple):1369:
S281.
|
|
Mok C.C., Ho C.T.K.,
Siu Y.P., Chan K.W., Kwan T.H., Lau
W.C.S., Wong
R.W.S. and Au T.C., Treatment of diffuse proliferative
lupus glomerulonephritis: a comparison of two cyclophosphamide-containing
regimens, American Journal of Kidney Diseases.
2001, 28(2): 256-64.
|
|
Yeung D., Ng G., Wong
R.W.S. and Lau
W.C.S., Rehabilitation of patients with rheumatoid
arthritis by Tai Chi Chuen training, Arthritis &
Rheumatism. 2001, 44(9 Supple):947: S210.
|
|
Fung F.M.Y.,
Wong W.M.,
Lam S.K., Yee
Y.K., Hung W.K., Yip W.C., Szeto M.L., Tong
S.M., Lai K.C.,
Hu H.C., Hui
C.K. and Wong B.C.Y.,
Rabeprazole based 3-day and 7-day triple therapy vs
7-day omeprazole based triple therapy for the treatment
of Helicobacter pylori infection, Journal
of Gastroenterology and Hepatology. 2001, 16
(9 suppl): A127.
|
|
Gu Q., Wong W.M.,
Lam S.K., Yin
Y., Wang W.H., Fung
F.M.Y., Lai
K.C., Xia H.H.X.,
Wong B.C.Y.
and Xiao S.D., One week omeprazole, furazolidone and
amoxycillin rescue therapy after failure of Helicobacter
pylori eradication with standard triple therapies,
Gastroenterology.
2002, 122 (4 suppl 1): A586.
|
|
Hu H.C., Wong Y.H., Lai K.C., Hui
W.M., Lam K.F.,
Wong B.C.Y.,
Xia H.H.X.,
Chan C.K.,
Wong W.M.,
Tsang K.W.T.
and Lam S.K.,
Normal 24-hour ambulatory proximal and distal gastroesophageal
reflux parameters in Chinese, Hong Kong Medical
Journal. Hong Kong, Hong Kong Academy of Medicine
and the Medical Association, 2002, 8: 168-171.
|
|
Lai K.C., Lam S.K., Chu
K.M., Wong
B.C.Y., Hui
W.M., Hu H.C.,
Lau G., Wong W.M.,
Yuen M.F.,
Chan A.O.O., Lai
C.L. and Wong
J., Lansoprazole for the prevention of recurrences
of ulcer complications from long-term low-dose aspirin
use, New
England Journal of Medicine. 2002, 346(26):
2033-2038.
|
|
Ng F.H., Wong
W.M., Wong
B.C.Y., Kng C., Wong S.Y., Lai
K.C., Cheng C.S., Yuen W.C., Lam
S.K. and Lai
C.L., Sequential intravenous/oral antibiotic vs.
continuous intravenous antibiotic in the treatment
of pyogenic liver abscess., Alimentary
Pharmacology and Therapeutics. 2002, 16(6):
1083-1September 0.
|
|
Wong B.C.Y.,
Wang W.P., So H.L.,
Shin V.Y.,
Wong W.M.,
Fung F.M.Y.,
Liu E.S.L.,
Hui W.M., Lam S.K. and Cho C.H., Epidermal
growth factor and its receptor in chronic active gastritis
and gastroduodenal ulcer before and after Helicobacter
pylori eradication, Alimentary
Pharmacology and Therapeutics. 2001, 15(9):
1459-1465.
|
|
Wong B.C.Y.,
Lam S.K., Wong W.M.,
Zheng T., Chen
J.S., Chen B.W., Lai
K.C., Yuen
S.T. and Ho
J.C.Y., Eradicating Helicobacter pylori infection
in general population prevents gastric cancer: 1 7
year prospective randomized placebo-controlled study,
Gstroenterology.
2002, 122 (4 suppl 1): A588.
|
|
Wong B.C.Y.,
Lam S.K., Wong W.M.,
Feng R.E., Zheng
T., Yuen S.T.,
Ho J.C.Y., Leung S.Y., Chen
J.S. and Lai K.C.,
Eradication of Helicobacter pylori infection significantly
slows down the progression of precancerous lesions
in high risk population: a 5-year prospective randomized
study, Gastroenterology.
2002, 122 (4 suppl 1): A588.
|
|
Wong B.C.Y.,
Wong W.M.,
Yee Y.K., Hung W.K., Yip A.W., Seto M.L., Li K.F.,
Lau P., Fung F.M.Y.,
Tong S.M.,
Lai K.C., Hu H.C., Yuen
M.F., Hui C.K. and Lam
S.K., Rabeprazole-based 3-day and 7-day triple
therapy vs omeprazole-based 7-day triple therapy for
the treatment of Helicobacter pylori infection, Alimentary
Pharmacology and Therapeutics. 2001, 15(12):
1959-1965.
|
|
Wong W.M.,
Wong B.C.Y.,
Xia H.H.X.,
Tang V.S., Lai
K.C., Hu H.C.,
Yuen M.F.,
Chan C.K. and
Lam S.K., An
evaluation of a rapid urine test for the diagnosis
of Helicobacter pylori infection in the Chinese population,
Alimentary
Pharmacology and Therapeutics. 2002, 16(4):
813-817.
|
|
Wong W.M.,
Wong B.C.Y.,
Tang V.S.Y., Wong K.W., Li T.M., Cheung K.L., Fung
F.M.Y., Lai
K.C., Hu H.C.,
Chan C.K.,
Xia H.H.X.
and Lam S.K.,
Evaluation of three near patient tests for the diagnosis
of Helicobacter pylori infectino in Chinese population,
The
Hong Kong Practitioner. 2002, 24 (2 suppl):
43.
|
|
Wong W.M.,
Mandir N., Goodlad R.A., Wong
B.C.Y., Garcia S.B., Lam
S.K. and Wright A., Histogenesis of human colorectal
adenomas and hyperplastic polyps: the role of cell
proliferation and crypt fission, Gut.
2002, 50(2): 212-217.
|
|
Wong W.M.,
Wong B.C.Y.,
Lu H., Gu Q.,
Yin Y., Wang W.H., Fung
F.M.Y., Lai
K.C., Xia H.H.X.,
Xiao D. and Lam
S.K., One-week omeprazole, furazolidone and amoxicillin
rescue therapy after failure of Helicobacter pylori
eradication with standard triple therapies, Alimentary
Pharmacology and Therapeutics. 2002, 16(4):
793-798.
|
|
Wong W.M.,
Gu Q., Lam
S.K., Fung
F.M.Y., Lai
K.C., Xia H.H.X.,
Hu H.C. and
Wong B.C.Y.,
Randomized controlled trial of rabeprazole, levofloxacin
and rifabutin triple therapy versus rabeprazole-based
quadruple therapy as a rescue treatment for failure
of Helicobacter pylori eradication with standard tiple
therapies, Gastroenterology.
2002, 122 (4 suppl 1): A587.
|
|
Wong W.M.,
Lai K.C., Lau C.P., Hu
H.C., Chen
W.H., Wong
B.C.Y., Hui
W.M., Wong
Y.H., Xia H.H.X.
and Lam S.K.,
Upper gastrointestinal evaluation of Chinese Patients
with non-cardiac chest pain, Alimentary
Pharmacology and Therapeutics. 2002, 16(3):
465-471.
|
|
Wong W.M.,
Lai K.C., Lau C.P., Hu
H.C., Chen
W.H., Wong
B.C.Y., Hui
W.M., Wong
Y.H., Xia H.H.X.
and Lam S.K.,
Upper gastrointestinal evaluation of Chinese patients
with noncardiac chest pain, The
Hong Kong Practitioner. 2002, 24 (2 suppl):
44.
|
|
Xia H.H.X.,
Wong B.C.Y.,
Wong K.W., Wong S.Y., Wong
W.M., Lai
K.C., Hu H.C.,
Chan C.K. and
Lam S.K., Clinical
and endoscopic characteristics of non-Helicobacter
pylori, non-NSAID duodenal ulcers: a long-term prospective
study, Alimentary
Pharmacology and Therapeutics. 2001, 15(12):
1875-1882.
|
|
Xia H.H.X.,
Wong B.C.Y.,
Huang X.R., He X.X., Wong
W.M., Leung
S.Y., Yuen
S.T., Lan H.Y.
and Lam S.K.,
Expression of macrophage migration inhibitory factor
in Helicobacter pylori induced gastritis and peptic
ulcer disease, The
Hong Kong Practitioner. 2002, 24 (2 suppl):
41.
|
|
Xia H.H.X.,
Wong B.C.Y.,
Wong W.M.,
Tang V.S., Cheung H.K., Sham F.N., Fung
F.M.Y., Lai
K.C., Hu H.C.,
Chan C.K. and
Lam S.K., Optimal
serological tests for the detection of Helicobacter
pylori infection in the Chinese population, Alimentary
Pharmacology and Therapeutics. 2002, 16(3):
521-526.
|
|
Tan K.C.B.,
Chow W.S., Wong
Y., Shiu
S.W.M. and Tam
S.C.F., Effects of Angiotensin II Receptor Antagonist
on Plasma C-reactive Protein and Urinary Albumin Excretion
in Type 2 Diabetic Patients with Microalbuminuria,
American Diabetes Association 62nd Annual Meeting
and Scientific Sessions. San Francisco, June 2002.
USA.
|
|
Tan K.C.B.,
Shiu S.W.M.
and Wong Y.,
Glycaemic control is a major determinant of plasma
phospholipid transfer protein activity in patients
with type 2 diabetes mellitus, 5th International
Diabetes Federation Western Pacific Region Congress.
Beijing, May 2002. PRC.
|
|
Hu H.C., Wong Y.H.,
Lai K.C., Hui W.M., Lam
K.F., Wong
B.C.Y., Xia
H.H.X., Chan
C.K., Wong
W.M., Tsang
K.W.T. and Lam
S.K., Normal 24-hour ambulatory proximal and distal
gastroesophageal reflux parameters in Chinese, Hong
Kong Medical Journal. Hong Kong, Hong Kong Academy
of Medicine and the Medical Association, 2002, 8: 168-171.
|
|
Hu H.C., Lam K.F., Wong Y.H.,
Lam C.L.K.,
Hui W.M., Lai K.C., Wong
B.C.Y. and Lam
S.K., The Hong Kong index of dyspepsia: A validated
symptom severity questionnaire for patients with dyspepsia,
Journal
of Gastroenterology and Hepatology. Melbourne,
Australia, Blackwell Science, 2002, 17: 545-551.
|
|
Wong W.M.,
Lai K.C., Lau C.P., Hu
H.C., Chen
W.H., Wong
B.C.Y., Hui
W.M., Wong
Y.H., Xia
H.H.X. and Lam
S.K., Upper gastrointestinal evaluation of Chinese
Patients with non-cardiac chest pain, Alimentary
Pharmacology and Therapeutics. 2002, 16(3):
465-471.
|
|
Wong W.M.,
Lai K.C., Lau C.P., Hu
H.C., Chen
W.H., Wong
B.C.Y., Hui
W.M., Wong
Y.H., Xia
H.H.X. and Lam
S.K., Upper gastrointestinal evaluation of Chinese
patients with noncardiac chest pain, The
Hong Kong Practitioner. 2002, 24 (2 suppl):
44.
|
|
Wong W.M.R.,
The Pathology, Diagnosis and Treatment of Helicobacter
pylori Infection (Doctor of Medicine). 2001.
|
| Project Title: | B cell apoptosis in
systemic lupus erythematosus |
| Investigator(s): | Dr.
Wu A.Y.Y., Prof. Lau W.C.S. |
| Department: | Medicine |
| Source(s) of Funding: | Hong
Kong Research Grants Council Competitive Earmarked
Research Grants |
| Start Date: | November 1998 |
| Abstract: |
| To identify possible defects in apoptosis during
B cell activation in patients with systemic lupus erythematosus
(SLE), and study the importance of T cell cytokine
profiles in the production of autoantibodies. The
project will also investigate the mechanisms that may
underlie such abnormalities by studying the expression
of genes associated with apoptosis. |
| Project Title: | B cell apoptosis in
systemic lupus erythematosus |
| Investigator(s): | Dr.
Wu A.Y.Y., Prof. Lau W.C.S. |
| Department: | Medicine |
| Source(s) of Funding: | RGC
Fundable Projects (Block Grant Funded) |
| Start Date: | November 1998 |
| Abstract: |
| To identify possible defects in apoptosis during
B cell activation in patients with systemic lupus erythematosus
(SLE), and study the importance of T cell cytokine
profiles in the production of autoantibodies. The
project will also investigate the mechanisms that may
underlie such abnormalities by studying the expression
of genes associated with apoptosis. |
| Project Title: | Effects of triptolide
in an animal model of contact dermatitis |
| Investigator(s): | Dr.
Wu A.Y.Y. |
| Department: | Medicine |
| Source(s) of Funding: | Vice-Chancellor's
Development Fund on Chinese Medicine |
| Start Date: | March 2000 |
| Abstract: |
| To determine the effectiveness of tropical
triptolide using an animal model of contact dermatitis |
| Project Title: | Immunological changes
in patients receiving sublingual immunotherapy for
allergic rhinitis |
| Investigator(s): | Dr.
Wu A.Y.Y., Dr. Yuen P.W. |
| Department: | Medicine |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | November 2001 |
| Abstract: |
| To investigate the clinical efficacy of HDM
SLIT in allergic rhinitis; to investigate the immunological
changes associated with the administration of SLIT. |
|
Li W. and Wu
A.Y.Y., Anti-inflammatory effects of montelukast
in a mouse model of asthma, J Allergy Clin Immunol.
2002, 1September (1 pt 2): S18.
|
|
Tong T.K., Yeung
J.S.L., Yang
D., Wu A.Y.Y.,
Chan W.K.,
Chiu P.K.Y.,
Tang W.M. and
Lau W.C.S.,
Effects of triptolide, an active ingredient of trypterygium
Wilfordii Hook F (Thunder God Vine, a traditional Chinese
herb), on rheumatoid synovial fibroblast function,
The Hong Kong Practitioner. 2001, 23(2)(Supple):
33.
|
|
Tong T.K., Yeung
J.S.L., Yang
D., Wu A.Y.Y.,
Chan W.K.,
Chiu P.K.Y.,
Tang W.M. and
Lau W.C.S.,
Effects of triptolide, an active ingredient of trypterygium
Wilfordii hook F (thunder god vine, a traditional Chinese
herb), on rheumatoid synovial fibroblast function,
Annals of the Rheumatic Diseases. 2001, 8(supple):
107.
|
|
Wong L.P., Woo
P.C.Y., Wu
A.Y.Y. and Yuen
K.Y., DNA immunization using a secreted cell wall
antigen Mp1p is protective against penicillium marneffei
infection, Vaccine.
2002, 3262: 1-9.
|
|
Wu A.Y.Y.,
Chan W.K.,
Chik S.C.C.,
Ren Y. and
Lau W.C.S.,
B cells from SLE patients display accelerated apoptosis
and reduced anti-apoptotic response to sIgM and CD40
ligation, The Hong Kong Practitioner. 2001,
23(2)(Supple): 33.
|
|
Wu A.Y.Y.,
Penicillin and cephalosporin allergies-an update, Current
Allergy Clin Immunol. 2001, 14(4): 14.
|
|
Yuen M.F.,
Hui C.K., Cheng C.C., Wu
C.H., Lai Y.P. and Lai
C.L., Long-term follow-up of interferon alfa treatment
in Chinese patients with chronic hepatitis B infection:
The effect on hepatitis B e antigen seroconversion
and the development of cirrhosis-related complications.,
Hepatology.
2001, 34(1): 139-145.
|
|
Wong B.C.Y.
and Wu J.,
Different approaches of incorporating TCM in treatment
of gastrointestinal diseases, Proceedings, TWGHs-HKU
Eddie Wang Chinese Medicine Symposium, 2-3 February.
2002, 47.
|
|
Wong B.C.Y.
and Wu J.,
Different approaches of incorporating traditional Chinese
medicine in the treatment of gastrointestinal diseases,
Proceedings, Symposium in Medical Sciences, 21st
Century Health Care in Hong Kong, A new era, 1-2 June.
2002.
|
| Project Title: | Expression of macrophage
migration inhibitory factor in response to Helicobacter
pylori and its role in regulation of inducible nitric
oxide synthase, necrosis factor-alpha and interleukin-1
in cell cultures |
| Investigator(s): | Dr.
Xia H.H.X., Dr. Wong B.C.Y. |
| Department: | Medicine |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | May 2001 |
| Abstract: |
| To determine the effect of H. pylori on the
production of macrophage MIF and the role of MIF in
up-regulation of inflammatory cytokines such as inducible
nitric oxide synthase (iNOS), tumour necrosis factor-alpha
(TNF-alpha) and interleukin-1 (IL-1) in cell culture. |
| Project Title: | Topographic association
of helicobacter pylori infection with apoptosis and
cell proliferation in the human stomach: roles of H.
pylori-induced antralization in the pathogenesis of
gastric cancer |
| Investigator(s): | Dr.
Xia H.H.X., Prof. Lam S.K., Dr. Wong B.C.Y. |
| Department: | Medicine |
| Source(s) of Funding: | Hong
Kong Research Grants Council Competitive Earmarked
Research Grants |
| Start Date: | October 2001 |
| Abstract: |
| To elucidate the carcinogenesis of H.pylori
infection at the molecular and cellular levels. |
| Project Title: | Molecular and genetic
mechanisms of Helicobacter pylori-induced antralization
in gastric carcinogenesis |
| Investigator(s): | Dr.
Xia H.H.X., Dr. Wong B.C.Y. |
| Department: | Medicine |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | February 2002 |
| Abstract: |
| To determine the expression of TFF2/hSP, MUC6,
Cdx-1 and Cdx-2 in the gastric antrum, incisura and
body in presence or absence of H. pylori infection. |
|
Gu Q., Wong
W.M., Lam S.K.,
Yin Y., Wang W.H., Fung
F.M.Y., Lai
K.C., Xia
H.H.X., Wong
B.C.Y. and Xiao S.D., One week omeprazole, furazolidone
and amoxycillin rescue therapy after failure of Helicobacter
pylori eradication with standard triple therapies,
Gastroenterology.
2002, 122 (4 suppl 1): A586.
|
|
Hu H.C., Wong Y.H., Lai K.C., Hui
W.M., Lam K.F.,
Wong B.C.Y.,
Xia H.H.X.,
Chan C.K.,
Wong W.M.,
Tsang K.W.T.
and Lam S.K.,
Normal 24-hour ambulatory proximal and distal gastroesophageal
reflux parameters in Chinese, Hong Kong Medical
Journal. Hong Kong, Hong Kong Academy of Medicine
and the Medical Association, 2002, 8: 168-171.
|
|
Wong B.C.Y.,
Yin Y., Berg D.E., Xia
H.H.X., Zhang J.Z., Wang W.H., Wong
B.C.Y., Huang X.R., Tang V.S. and Lam
S.K., Distribution of distinct vacA, cagA and iceA
alleles in Helicobacter pylori in Hong Kong, Helicobacter.
2001, 6(4): 317-324.
|
|
Wong W.M.,
Wong B.C.Y.,
Xia H.H.X.,
Tang V.S., Lai
K.C., Hu H.C.,
Yuen M.F.,
Chan C.K. and
Lam S.K., An
evaluation of a rapid urine test for the diagnosis
of Helicobacter pylori infection in the Chinese population,
Alimentary
Pharmacology and Therapeutics. 2002, 16(4):
813-817.
|
|
Wong W.M.,
Wong B.C.Y.,
Tang V.S.Y., Wong K.W., Li T.M., Cheung K.L., Fung
F.M.Y., Lai
K.C., Hu H.C.,
Chan C.K.,
Xia H.H.X.
and Lam S.K.,
Evaluation of three near patient tests for the diagnosis
of Helicobacter pylori infectino in Chinese population,
The
Hong Kong Practitioner. 2002, 24 (2 suppl):
43.
|
|
Wong W.M.,
Wong B.C.Y.,
Lu H., Gu Q.,
Yin Y., Wang W.H., Fung
F.M.Y., Lai
K.C., Xia
H.H.X., Xiao D. and Lam
S.K., One-week omeprazole, furazolidone and amoxicillin
rescue therapy after failure of Helicobacter pylori
eradication with standard triple therapies, Alimentary
Pharmacology and Therapeutics. 2002, 16(4):
793-798.
|
|
Wong W.M.,
Gu Q., Lam
S.K., Fung
F.M.Y., Lai
K.C., Xia
H.H.X., Hu
H.C. and Wong
B.C.Y., Randomized controlled trial of rabeprazole,
levofloxacin and rifabutin triple therapy versus rabeprazole-based
quadruple therapy as a rescue treatment for failure
of Helicobacter pylori eradication with standard tiple
therapies, Gastroenterology.
2002, 122 (4 suppl 1): A587.
|
|
Wong W.M.,
Lai K.C., Lau C.P., Hu
H.C., Chen
W.H., Wong
B.C.Y., Hui
W.M., Wong
Y.H., Xia
H.H.X. and Lam
S.K., Upper gastrointestinal evaluation of Chinese
Patients with non-cardiac chest pain, Alimentary
Pharmacology and Therapeutics. 2002, 16(3):
465-471.
|
|
Wong W.M.,
Lai K.C., Lau C.P., Hu
H.C., Chen
W.H., Wong
B.C.Y., Hui
W.M., Wong
Y.H., Xia
H.H.X. and Lam
S.K., Upper gastrointestinal evaluation of Chinese
patients with noncardiac chest pain, The
Hong Kong Practitioner. 2002, 24 (2 suppl):
44.
|
|
Xia H.H.X.,
Wong B.C.Y.,
Wong K.W., Wong S.Y., Wong
W.M., Lai K.C.,
Hu H.C., Chan C.K. and
Lam S.K., Clinical
and endoscopic characteristics of non-Helicobacter
pylori, non-NSAID duodenal ulcers: a long-term prospective
study, Alimentary
Pharmacology and Therapeutics. 2001, 15(12):
1875-1882.
|
|
Xia H.H.X.,
Wong B.C.Y.,
Huang X.R., He X.X., Wong
W.M., Leung
S.Y., Yuen
S.T., Lan H.Y.
and Lam S.K.,
Expression of macrophage migration inhibitory factor
in Helicobacter pylori induced gastritis and peptic
ulcer disease, The
Hong Kong Practitioner. 2002, 24 (2 suppl):
41.
|
|
Xia H.H.X.,
Wong B.C.Y.
and Lam S.K.,
Helicobacter pylori infection and gastroduodenal muscosal
damage and healing, Gastrointestinal mucosal repair
and experimental therapeutics. Front Gastrointest
Res. Switzerland, S Karger AG, 2002, 143-157.
|
|
Xia H.H.X.,
Wong B.C.Y.,
Wong W.M.,
Tang V.S., Cheung H.K., Sham F.N., Fung
F.M.Y., Lai
K.C., Hu H.C.,
Chan C.K. and
Lam S.K., Optimal
serological tests for the detection of Helicobacter
pylori infection in the Chinese population, Alimentary
Pharmacology and Therapeutics. 2002, 16(3):
521-526.
|
|
Xu J.,
Zhang W., Chan V.N.Y. and
Lam K.S.L.,
Functional Analysis of Mutations in the Hepatocyte
Nuclear Factor-1 alpha Gene in Chinese MODY Families,
Sixth Research Postgraduate Symposium, September
26-28, 2001, The University of Hong Kong, Hong Kong.
2001.
|
|
Xu J.,
Zhang W., Chan V.N.Y. and
Lam K.S.L.,
Mutations in the Hepatocyte Nuclear Factor-1 alpha
Gene in Chinese MODY Families: Prevalence and Functional
Analysis., Second International Huaxia Congress
of Endocrinology, December 14-17, 2001. Hong Kong.
|
|
Lam C.L., Lam W.K.,
Yip T.C., Ooi C.G.C.,
Lam B., Ip S., Wang J., Ho J.C.M., Yan
C.P.K., Chan
L.Y., Zheng L., Man
R.Y.K. and Tsang
K.W.T., Effects of herbal preparation, corioulus
versicolor Yun-zhi, on non-small cell lung cancer (NSCLC),
Medical Research Conference, University Department
of Medicine, Hong Kong, 2001. The Hong Kong Practitioner.
2001, 23 (supp 2): 28 (G-RM-8).
|
|
Lam C.L., Lam W.K.,
Ho J.C.M., Yan
C.P.K., Chan S., Lam B., Zheng L., Ooi
C.G.C. and Tsang
K.W.T., Effects of yun-zhi on non-small cell lung
cancer (NSCLC), American Journal of Respiratory
Critical Care Medicine. 2001, 163(5): A67.
|
|
Lam C.L., Lam W.K.,
Ip M.S.M.,
Tsang K.W.T.,
Lam B., Yan
C.P.K., Ho J.C.M., Ip S. and Wong M.K.Y., The
combined use of gemcitabine and ifosfamide in patients
with Stage III or IV non-small cell lung cancer (NSCLC),
Medical Research Conference, University Department
of Medicine, Hong Kong, 2002. The Hong Kong Practitioner.
2002, 24(2): 55 (C-RC-3).
|
|
Zheng L., Lam W.K.,
Shum H.Y.I.,
Tipoe G.L.,
Yan C.P.K.,
Leung Y.H.,
Sun J.Z., Ooi C.G.C., Ip M.S.M. and
Tsang K.W.T.,
Expression of matric matelloproteinase-8 and 9 is raised
in the airways of patients with bronchiectasis in vivo,
The Hong Kong Practitioner. 2001, 23(Suppl 2):
64.
|
|
Zheng L., Lam W.K.,
Shum H.Y.I.,
Tipoe G.L.,
Yan C.P.K.,
Leung Y.H.,
Sun J.Z., Ooi C.G.C., Ip M.S.M. and
Tsang K.W.T.,
Over expression of matrix metalloproteinase-8 (MMP-8)
and -9 (MMP-9) in bronchiectatic airways in vivo, Medical
Research Conference, University Department of Medicine,
Hong Kong, 2001. The Hong Kong Practitioner. 2001,
23 (suppl 2): 64 (S-RM-1).
|
|
Zheng L., Lam W.K.,
Tipoe G.L.,
Shum H.Y.I.,
Yan C.P.K.,
Leung Y.H.,
Sun J.Z., Ooi C.G.C. and
Tsang K.W.T.,
Overexpression of matrix metalloporteinase-8 and -9
in bronchiectatic airways in vivo, European Respiratory
Journal. 2002, 20: 170-176.
|
|
Zheng L., Shum
H.Y.I., Lam
W.K., Tipoe
G.L., Yan
C.P.K., Ooi
C.G.C., Ho J.C.M., Fung
P.C.W., Ip
M.S.M. and Tsang
K.W.T., Overexpression of matrix metalloproteinase-8
(MMP-8) and-9 in bronchiectatic airways in vivo, American
Journal of Respiratiry and Critical Care Medicine.
2001, 163(5): A671.
|
|
Tong T.K., Yeung
J.S.L., Fung D.M., Lai
C.L. and Lau
W.C.S., Alterations of CD8+CD28- T cells in systemic
lupus erythematosus (SLE) and rheumatoid arthritis
(RA), 20th Congress of the ILAR. 2001, W13:
79.
|
|
Tong T.K., Yeung
J.S.L., Yang
D., Wu A.Y.Y.,
Chan W.K.,
Chiu P.K.Y.,
Tang W.M. and
Lau W.C.S.,
Effects of triptolide, an active ingredient of trypterygium
Wilfordii Hook F (Thunder God Vine, a traditional Chinese
herb), on rheumatoid synovial fibroblast function,
The Hong Kong Practitioner. 2001, 23(2)(Supple):
33.
|
|
Tong T.K., Yeung
J.S.L., Yang
D., Wu A.Y.Y.,
Chan W.K.,
Chiu P.K.Y.,
Tang W.M. and
Lau W.C.S.,
Effects of triptolide, an active ingredient of trypterygium
Wilfordii hook F (thunder god vine, a traditional Chinese
herb), on rheumatoid synovial fibroblast function,
Annals of the Rheumatic Diseases. 2001, 8(supple):
107.
|
|
Lau C.P., Tse H.F., Yu C.M., Teo
W.S., Kam R., Ng K.S., Huang S.S., Lin J.L., Fitts
S.M., Hettrick D.A. and Hill M.R., Dual-site atrial
pacing for atrial fibrillation in patients without
bradycardia., Am J Cardiol. 2001, 88: 371-5.
|
|
Tse H.F., Wang
Q., Yu C.M.,
Ayers G. and Lau
C.P., Effect of verapamil on prevention of atrial
fibrillation in patients implanted with an implantable
atrial defibrillator, Clin. Cardiol. 2001, 24(7):
503-505.
|
|
Yu C.M.,
Tipoe G.L., Lai K.W.H. and Lau
C.P., Effects of combination of angiotensin-converting
enzyme inhibitor and angiotensin receptor antagonist
on inflammatory cellular infiltration and myocardial
interstitial fibrosis after acute myocardial infarction.,
J Am Coll Cardiol. 2001, 38: 1207-15.
|
|
Yu C.M.,
Lau C.P., Lai
K.W., Huang X.R., Chen
W.H. and Lan
H.Y., Elevation of plasma level of macrophage migration
inhibitory factor in patients with acute myocardial
infarction., Am J Cardiol. 2001, 88: 774-7.
|
|
Yu C.M.,
Cheung B.M.Y.,
Leung R., Wang Q., Lai W.H. and Lau
C.P., Increase in plasma adrenomedulin in patients
with heart failure characterised by diastolic dysfunction.,
Heart. 2001, 86(2): 155-160.
|
|
Yu C.M.
and Lau C.P.,
Left ventricular reverse remodeling after biventricular
pacing in heart failure, In: Ovsyshcher IE, New
Developments in Cardiac Pacing and Electrophysiology.
Armonk, NY, Futura Publishing Co Inc, 2002, 221-227.
|
|
Yu C.M.,
Chau M.C.,
Sanderson J.E., Fan
Y.Y., Tang
M.O., Fung W.H., Lin
H., Kong S.L.,
Lam Y.M., Hill
M.R. and Lau C.P.,
Tissue Doppler echocardiographic evidence of reverse
remodeling and improved synchronicity by simultaneously
delaying regional contraction after biventricular pacing
therapy in heart failure., In: , Circulation.
2002, 105: 438-45.
|
|
Yu C.M.,
Tse H.F., Chau M.C., Fan Y.Y., Lee
K.L.F., Leung S.K., Wan S.H. and Lau
C.P., 雙心室起搏治療心力衰竭的初步經驗, In: , 中華心律失常學雜誌, 2002,
4.
|
|
Yuen M.F.,
Sablon E., Hui C.K., Yuan
H., Decraemer H. and Lai
C.L., Factors associated with hepatitis B virus
DNA breakthrough in patients receiving prolonged lamivudine
therapy., Hepatology.
2001, 34(4 Pt 1): 785-791.
|
|
Chan A.O.O., Yuen
M.F., Hui C.K., Tso
W.K. and Lai
C.L., A prospective study regarding the complications
of transcatheter intraarterial lipiodol chemoembolization
in patients with hepatocellular carcinoma., Cancer.
2002, 94(6): 1747-1752.
|
|
Lai K.C., Lam S.K., Chu
K.M., Wong
B.C.Y., Hui
W.M., Hu H.C.,
Lau G., Wong W.M., Yuen M.F.,
Chan A.O.O., Lai
C.L. and Wong
J., Lansoprazole for the prevention of recurrences
of ulcer complications from long-term low-dose aspirin
use, New
England Journal of Medicine. 2002, 346(26):
2033-2038.
|
|
To Y.F., Yuen M.F.,
Poon R.T.P.,
Ip E.W.K.,
Lai C.L. and
Lau Y.L., Mannose
binding lectin polymorphisms and hepatitis B infection
in Chinese, 11th International Congress of Immunology,
Stockholm, Sweden, 23-27 July 2001(Poster presentation;
FIMSA Travel Award). 2001, Suppl 1.
|
|
Wong B.C.Y.,
Wong W.M.,
Yee Y.K., Hung W.K., Yip A.W., Seto M.L., Li K.F.,
Lau P., Fung F.M.Y.,
Tong S.M.,
Lai K.C., Hu H.C., Yuen M.F.,
Hui C.K. and Lam
S.K., Rabeprazole-based 3-day and 7-day triple
therapy vs omeprazole-based 7-day triple therapy for
the treatment of Helicobacter pylori infection, Alimentary
Pharmacology and Therapeutics. 2001, 15(12):
1959-1965.
|
|
Wong W.M.,
Wong B.C.Y.,
Xia H.H.X.,
Tang V.S., Lai
K.C., Hu H.C.,
Yuen M.F.,
Chan C.K. and
Lam S.K., An
evaluation of a rapid urine test for the diagnosis
of Helicobacter pylori infection in the Chinese population,
Alimentary
Pharmacology and Therapeutics. 2002, 16(4):
813-817.
|
|
Yuen M.F.,
Chronic Hepatitis B Virus Infection in Chinese Patients:
Natural History, Sequelae, Treatment and Prevention
(Doctor of Medicine). 2001.
|
|
Yuen M.F.,
Chronic hepatitis B virus infection in the Chinese:
Natural history, sequelae, treatment and prevention,
MD thesis 2001. 2001.
|
|
Yuen M.F.,
Sablon E., Hui C.K., Yuan
H., Decraemer H. and Lai
C.L., Factors associated with hepatitis B virus
DNA breakthrough in patients receiving prolonged lamivudine
therapy., Hepatology.
2001, 34(4 Pt 1): 785-791.
|
|
Yuen M.F.,
Hui C.K., Cheng C.C., Wu
C.H., Lai Y.P. and Lai
C.L., Long-term follow-up of interferon alfa treatment
in Chinese patients with chronic hepatitis B infection:
The effect on hepatitis B e antigen seroconversion
and the development of cirrhosis-related complications.,
Hepatology.
2001, 34(1): 139-145.
|
|
Yuen M.F.
and Lai C.L.,
Treatment of chronic hepatitis B., Lancet Infectious
Diseases. 2001, 1(4): 232-241.
|
| Project Title: | Mechanisms of anti-DNA
antibody internalisation by human mesangial cells |
| Investigator(s): | Dr.
Yung S.S.Y., Prof. Chan D.T.M. |
| Department: | Medicine |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | February 2001 |
| Completion Date: | January2002 |
| Abstract: |
| To further characterise HMC membrane antigens
which mediate the binding of anti-DNA immunoglobulins;
to determine whether anti-DNA antibody can be internalised
by HMC into the cytoplasm and/or nucleus; to examine
changes in HMC morphology, viability and apoptosis
following the binding and/or internalisation of anti-DNA
antibodies; to correlate these in vitro fidnings to
clinical disease activity. |
| Project Title: | Effects of anti-DNA
antibodies on the synthesis of hyaluronan by human
mesangial cells |
| Investigator(s): | Dr.
Yung S.S.Y., Prof. Chan D.T.M. |
| Department: | Medicine |
| Source(s) of Funding: | Hong
Kong Research Grants Council Competitive Earmarked
Research Grants |
| Start Date: | September /2001 |
| Abstract: |
| To determine the concentration and molecular
weight of circulating HA in relation to disease activity
in diffuse proliferative lupus nephritis; to examine
histologically the expression of HA, the enzymes for
HA synthesis (i.e. HAS and uridine diphosphoglucose
dehydrogenase, UDPGD), HA receptor CD44, and inflammatory
cytokines IL-Ibeta and TNF-alpha in renal biopsies
of diffuse proliferatve lupus nephritis; to exmine
the effects of anti-DNA antibodies on HA synthesis
and degradation by HMC; to determine the effects of
anti-DNA antibodies on the expression of UDPGD, HAS,
CD44 and the above cytokines in cultured HMC. |
| Project Title: | The effect of mycophenolate
mofetil (MMF) on the viability and apoptosis of human
mesangial cell and its synthesis of cytokines and matrix
proteins in lupus nephritis |
| Investigator(s): | Dr.
Yung S.S.Y., Prof. Chan D.T.M. |
| Department: | Medicine |
| Source(s) of Funding: | Block
Grant Earmarked for Research |
| Start Date: | November 2001 |
| Abstract: |
| To investigate the effects of MMF on: (1) human
mesangial cell (HMC) proliferation, viability, and
apoptosis; (2) the synthesis and secretion of pro-inflammatory\pro-fibrotic
cytokines interleuk-1Beta (IL-IBeta), interleukin-12
(IL-2), tumour necrosis factor-alfa (TNF-alfa), and
transforming growth factor-Beta (TGF-Beta) in HMC;
and 3. matrix proteins synthesis by HMC. |
|
Chan D.T.M.,
Leung J.K.H.,
Lai K.N. and
Yung S.S.Y.,
Mechanisms of interaction between anti-DNA antibodies
and human mesangial cells in systemic lupus erythematosus
[presented at the 33rd Annual Meeting of the American
Society of Nephrology], Journal of American Society
of Nephrology. October 11-16, Toronto, Canada,
2001, 11: A2492.
|
|
Yung S.S.Y.,
Liu Z.H., Li L.S., Lai
K.N. and Chan
D.T.M., Emodin ameliorates excessive fibronectin
synthesis by human peritoneal mesothelial cells (HPMC).
[Abstract presented at the Annual Meeting of the American
Society of Nephrology, Oct 10-17, 2001, San Francisco,
USA], Journal of the American Society of Nephrology.
2001, 12: 722A.
|
|
Xu J., Zhang W.,
Chan V.N.Y.
and Lam K.S.L.,
Functional Analysis of Mutations in the Hepatocyte
Nuclear Factor-1 alpha Gene in Chinese MODY Families,
Sixth Research Postgraduate Symposium, September
26-28, 2001, The University of Hong Kong, Hong Kong.
2001.
|
|
Xu J., Zhang W.,
Chan V.N.Y.
and Lam K.S.L.,
Mutations in the Hepatocyte Nuclear Factor-1 alpha
Gene in Chinese MODY Families: Prevalence and Functional
Analysis., Second International Huaxia Congress
of Endocrinology, December 14-17, 2001. Hong Kong.
|
|
Wong B.C.Y.,
Lam S.K., Wong W.M., Zheng T.,
Chen J.S., Chen B.W., Lai
K.C., Yuen
S.T. and Ho
J.C.Y., Eradicating Helicobacter pylori infection
in general population prevents gastric cancer: 1 7
year prospective randomized placebo-controlled study,
Gstroenterology.
2002, 122 (4 suppl 1): A588.
|
|
Wong B.C.Y.,
Lam S.K., Wong W.M., Feng
R.E., Zheng
T., Yuen
S.T., Ho J.C.Y.,
Leung S.Y.,
Chen J.S. and Lai
K.C., Eradication of Helicobacter pylori infection
significantly slows down the progression of precancerous
lesions in high risk population: a 5-year prospective
randomized study, Gastroenterology.
2002, 122 (4 suppl 1): A588.
|
-- End of Listing --
|
