DEPARTMENT OF PATHOLOGY
Researchers:
Beh S.L. Chan C.F. Chan E.Y.T. Chan K.L. Chan K.W.
Chan L.C. Chan Y.K. Cheung A.N.Y. Chiang A.K.S. Chiu P.M.
Chow S.N.L. Chung L.P. Collins R.J. Fong P.Y. Fung L.F.
Hawkins B.R. Higgins D.A. Ho J.C.Y. Hu Y. Huang F.
Khoo U.S. Kinoshita R.E. Lam C.C.K. Lam K.Y. Lee C.K.
Lee M.F. Lee M.Y. Leung S.Y. Liang A.C.T. Loong F.
Lu L. Ma E.S.K. Nanji A.A. Ng I.O.L. Ng S.W.
Nicholls J.M. Poon A.Y.A. Qin L. Shek T.W.H. Shen L.
So C.K.C. Srivastava G. Tam S.C.F. Tang C.O. Tin P.C.
Trendell-Smith N.J. Tsui W.Y. Wan T.S.K. Wong M.P. Xue W.
Yam J.W.P. Yuen S.T.


Researcher : Beh SL
List of Research Outputs

Beh S.L., A good problem-based tutor - how do we know?, Presented at the 2nd Asia Pacific Conference on Problem-Based Learning in Health Sciences in Kuala Lumpur, Malaysia, October. 2001.
Beh S.L., Death due to human bites and other short stories, Presented at the 7th Indo-Pacific Congress on Legal Medicine and Forensic Science in Melbourne, Australia, September. 2001.
Beh S.L., Domestic rape, Presented at the 7th Indo-Pacific Congress on Legal Medicine and Forensic Science, Melbourne, Australia, September. 2001.
Beh S.L., International Editorial Board Member, Journal of Clinical Forensic Medicine (Official Journal of the Association of Police Surgeons and the Australia and New Zealand Forensic Medicine Society). Churchill Livingstone, 2002.
Beh S.L., Persons who experienced sexual violence, Invited Member of the Planning Meeting of Study on Indicators of Quality of Medicolegal Services at the World Health Organisation in Geneva, Switzerland, February. 2002.
Beh S.L., Problem-Based Learning - An exciting way to learn forensic medicine, 7th Indo-Pacific Congress on Legal Medicine and Forensic Science in Melbourne, Australia, September. 2001.
Beh S.L., Rape - why are victims not reporting?, Presented at the 2nd Annual Symposium of Crime and its Control in Greater China Conference, Hong Kong, October. 2001.
Beh S.L., Sexual harassment on-line, The 6th World Police Medical Officers Conference in Sydney, Australia, March. 2002.
Beh S.L., Liang A., Daldrup T. and Rickert A., Toxicological analysis of hair in drug deaths - a pilot study, International Joint Congress - Challenges and Opportunities in Pathology, Hong Kong, October. 2001.
Beh S.L., Victim of rape - who cares?, Hong Kong Journal of Gynaecology, Obstetrics and Midwifery. 2002, 2: 40-44.
Broadhurst R.G., Beh S.L. and Chan C.Y., Homicide-Suicide in Hong Kong: A Preliminary Analysis of the Homicide Monitoring Data Base, 6th World Congress of Police Medical Officers, Sydney, March 17-21. 2002, Abstracts.
Chan C.Y., Beh S.L. and Broadhurst R.G., Homicide-suicide in Hong Kong, 1989-1997: a preliminary analysis, The 6th World Police Medical Officers Conference in Sydney, Australia, March. 2002.
Lee K.W., Broadhurst R.G. and Beh S.L., Gang & Triad Related Homicide in Hong Kong: A Preliminary Analysis of the Homicide Monitoring Data-Base 1989-1998, The Sixth International Conference in Clinical Forensic Medicine of the World Police Medical Officers, Australia March 17-22. 2002.
Lee K.W., Broadhurst R.G. and Beh S.L., Gang and triad related homicide in Hong Kong: a preliminary analysis of the homicide monitoring database 1989-1998, The 6th World Police Medical Officers Conference in Sydney, Australia, March. 2002.


Researcher : Chan CF
List of Research Outputs

Au W.Y., Shek T.W.H., Chan C.F., Chim J.C.S., Kwong Y.L., Ooi C.G.C. and Ho W.K., Unusual sites of involvement by hematologic malignancies: case 3. external auditory canal tumor: a rare chloroma in acute promyelocytic leukemia with a complete response to arsenic trioxide, Journal of Clinical Oncology. 2001, 19: 3993-3995.


Researcher : Chan EYT
List of Research Outputs

Au W.Y., Hawkins B.R., Lie A.K.W., Kung A.W.C., Kwong Y.L., Liang R.H.S. and Chan E.Y.T., Association of the HLA A2-B46-DR9 haplotype with atutoimmune thyroid dysfunction after bone marrow transplantation in Chinese patients., British Journal of Haematology. 2001, 115: 660-663.


Researcher : Chan KL
List of Research Outputs

Chan K.L., Lee M.F., Guan X.Y., Fan S.T. and Ng I.O.L., High-density allelotyping of chromosome 8p in hepatocellular carcinoma and clinicopathologic correlation, Cancer. 2002, 94(12): 3179-3185.


Researcher : Chan KW
Project Title:Growth and functions of human kidney tubular cells and transgenic mouse kidneys affected by mutated adult polycystic kidney disease gene, PKDl
Investigator(s):Dr. Chan K.W., Dr. Choo C.K., Dr. Chung S.K.
Department:Pathology
Source(s) of Funding:Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:September 1998
Abstract:
To find an effective treatment for APKD. In vito and in vivo models have enhanced similar researches in many other diseases. We think that the successful production of APKD models is crucial to future studies in APKD.


List of Research Outputs

Tang S.C.W., Leung J.C.K., Chan K.W., Chan Y.Y., Chan D.T.M. and Lai K.N., Induction of interleukin-8 in human proximal tubule cells: an in vitro and in vivo study. [Abstract presented at the Annual Meeting of the American Society of Nephrology, Oct 10-17, 2001, San Francisco, USA], Journal of the American Society of Nephrology. 2001, 12: 664A-665A.
Zheng B., Chan K.W., Im S.W.K., Chua D.T.T., Sham J.S.T., Tin P.C., He Z.M. and Ng M.H., Anti-tumor effects of human peripheral gamma-delta-T cells in a mouse tumor model, International Union Against Cancer. 2001, 92: 421-425.


Researcher : Chan LC
Project Title:Mechanism of leukaemic transformation by fusion genes
Investigator(s):Prof. Chan L.C., Dr. So C.W.
Department:Pathology
Source(s) of Funding:Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:September 1999
Abstract:
To understand the molecular basis of leukaemia by studying the effects of a fusion gene in leukaemia on cellular transformation and identifying interactions with candidate proteins.


Project Title:Synaptojanin-1 and tumour suppressor gene activity
Investigator(s):Prof. Chan L.C.
Department:Pathology
Source(s) of Funding:RGC Fundable Projects (Block Grant Funded)
Start Date:November 2000
Completion Date:October 2001
Abstract:
To investigate whether synaptojanin-1 has tumour suppressor gene function.


Project Title:The role of endophilin 2 in cell cycle regulation
Investigator(s):Prof. Chan L.C.
Department:Pathology
Source(s) of Funding:Block Grant Earmarked for Research
Start Date:November 2001
Abstract:
To investigate the cyclin binding motif of endophilin 2 so as to elucidate its role in cell cycle regulation.


List of Research Outputs

Au W.Y., Ma E.S.K., Chan L.C., So C.K.C., Fung L.F. and Shek T.W.H., Chromosome 11q deletion in myeloid malignancies, Leukemia and Lymphoma. 2002, 16: 953-955.
Chan L.C., Nicholls J.M. and Chan Y.S., Improving the quality of cases for problem-based learning (PBL): experience and feedback from Year 1 medical students, University of Hong Kong, Journal of Medical Education. 2002, 6(1): 95-99.
Chan L.C., Lam T.H., Li C.K., Lau Y.L., Li C.K., Yuen H.L., Lee C.W., Ha S.Y., Yuen P.M.P., Leung N.K., Patheal S.L., Greaves M.F. and Alexander F.E., Is the timing of exposure to infection a major determinant of acute lymphoblastic leukaemia in Hong Kong?, Pediatric and Perinatal Epidemiology. 2002, 16: 154-165.
Hu Y., Lam K.Y., Law S.Y.K., Wan T.S.K., Ma E.S.K., Kwong Y.L., Chan L.C., Wong J. and Srivastava G., Establishment, characterization, karyotyping, and comparative genomic hybridization analysis of HKESC-2 and HKESC-3: two newly established human esophageal squamous cell carcinoma cell lines, Cancer Genetics and Cytogenetics. 2002, 135: 120-127.
Ma E.S.K., Lee A.C.W., Chan A.Y.Y. and Chan L.C., A novel A ATAAA--> C ATAAA mutation at the polyadenylation site of the b-globin gene, British Journal of Haematology. 2001, 115(1): 230-231.
Ma E.S.K., Wan T.S.K., Au W.Y., Fung L.F., So C.K.C. and Chan L.C., Chromosome 11q deletion in myeloid malignancies, Leukemia. 2001, 16: 953-955.
Ma E.S.K., Chan A.Y.Y., Chiu E.K.W. and Chan L.C., Haemoglobin H disease due to (--SEA) a-globin gene deletion and a2-codon 30 (DGAG) mutation: a family study, Clinical and Laboratory Haematology. 2001, 23(5): 325-327.
Ma E.S.K., Chow E.Y.D., Chan A.Y.Y., Chu C.M., Lin S.Y. and Chan L.C., Low affinity and unstable hemoglobin variant caused by AAC->ATC (Asn->Ile) mutation at codon 108 of the b-globin gene, Haematologica. 2002, 87(5): 553-554.
Ma E.S.K., Chan Y.Y.A., Ha S.Y., Lau Y.L. and Chan L.C., Thalassaemia screening based on red cell indices in the Chinese, Haematologica. 2001, 86: 1310-1311.
Ma E.S.K., Chan L.C., Ha S.Y., Chan G.C.F., Chan A.Y. and Au W.Y., The (--SEA) alpha- thalassemia deletion ameliorates the clinical phenotype of beta Zero/beta plus thalassaemia but no necessarily beta zero/beta zero thalassaemia, Haematologica. 2002, 87: 4333-444.
Ma E.S.K., Chan A.Y.Y., Ha S.Y., Chan G.C.F., Au W.Y. and Chan L.C., The (--SEA) a-thalassemia (SEA) deletion ameliorates the clinical phenotype of b0 / b+ but not necessarily that of b0 / b0 thalassemia, Haematologica. 2001, 87(4): 443-444.
Ma Z., Morris S.W., Valentine V., Li M., Herbrick J., Cui X., Bouman D., Li Y., Mehta P.K., Nizetic D., Kaneko Y., Chan G.C.F., Chan L.C., Squire J., Scherer S.W. and Hitzler J.K., Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia, Nature Genetics. 2001, 28: 220-221.
Ng J.K.F., Lam C.C.K. and Chan L.C., In vivo effect of haemodilution with saline on coagulation: a randomised controlled trial, British Journal of Anaesthesia. UK, 2002, 88: 475-480.
Wan T.S.K., Ma E.S.K., Ho M.Y., Chan L.C., Yip S.F., Wong L.G. and Yeung Y.M., Cytogenetic biclonality in polycythemia vera: unusual and unrelated clones, Cancer Genetics and Cytogenetics. 2001, 131(1): 86-89.
Wan T.S.K., Yip S.F., Yeung Y.M., Chan L.C. and Ma E.S.K., Fatal diffuse alveolar damage complicating acute myeloid leukemia with abnormal eosinophils and trisomy X, Annals of Hematology. 2002, 81: 167-169.
Yusoff N.M., Abdullah W.Z., Ghazali S., Othman M.S., Baba A.A., Abdullah N., Isa M.N. and Chan L.C., The absence of factor V Leiden mutation in Malays with recurrent spontaneous abortions, Australian and New Zealand Journal of Obstetrics & Gynaecology. 2002, 42(20: 164-166.


Researcher : Chan YK
List of Research Outputs

Khoo U.S., Chan Y.K., Cheung A.N.Y., Xue W., Shen D.H., Fung K.Y., Ngan H.Y.S., Choy K.W., Pang C.P., Poon C.S.P., Poon A.Y.A. and Ozcelik H., Recurrent BRCA1 and BRCA2 germline mutations in ovarian cancer: a founder mutation of BRCA1 identified in the Chinese population, Human Mutation. 2002, 19(3): 307-308.


Researcher : Cheung ANY
Project Title:In situ analysis of tissue dynamics in gestational trophoblastic disease
Investigator(s):Dr. Cheung A.N.Y., Dr. Khoo U.S., Prof. Ngan H.Y.S.
Department:Pathology
Source(s) of Funding:Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:October 1998
Abstract:
To analyze the growth dynamics of different categories of gestational trophoblastic diseases with respect to their levels of cell proliferation and cell death. The proliferation and apoptotic markers in the various categories of GTD will be compared with each other and with the normal placenta to evaluate the role of growth dynamics in the pathogenesis of these diseases. Correlation with clinical outcome of the patients will be made to assess the prognostic significance of the markers. Possible effects from relevant oncogenes and growth factors will also be elucidated.


Project Title:Differential expression of genes in gestational trophoblastic diseases
Investigator(s):Dr. Cheung A.N.Y., Prof. Ngan H.Y.S., Dr. Tsao G.S.W.
Department:Pathology
Source(s) of Funding:Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:October 2000
Abstract:
To conduct a comprehensive investigation on gene expression in gestational trophoblastic diseases (GTD) using the cDNA array hybridization and the PCR based suppression substractive hybridzation (SSH) methods.


Project Title:Proliferative and apoptotic activities in ovarian tumour
Investigator(s):Dr. Cheung A.N.Y., Dr. Khoo U.S., Prof. Ngan H.Y.S.
Department:Pathology
Source(s) of Funding:Block Grant Earmarked for Research
Start Date:November 2000
Abstract:
To achieve a better understanding of the growth dynamics associated with the genesis and progression of the ovarian epithelial tumours.


Project Title:Genetic alterations in mitochondrial DNA in gestational trophoblastic diseases (GTD)
Investigator(s):Dr. Cheung A.N.Y., Dr. Liu V.W.S., Prof. Ngan H.Y.S.
Department:Pathology
Source(s) of Funding:Block Grant Earmarked for Research
Start Date:November 2001
Abstract:
To identify somatic mutations and polymorphisms of mitochondrial DNA (mtDNA) in hydatidiform mole (HM) using extra-long and standard polymerase chain reactions and automated DNA sequencing.


List of Research Outputs

Chan G.C.F., Lo G.M.Y.G. and Cheung A.N.Y., A Boy with Dyspepsia and Ascites, Hong Kong Journal of Paediatrics (New Series). 2002, 7: 49-50.
Khoo U.S., Chan Y.K., Cheung A.N.Y., Xue W., Shen D.H., Fung K.Y., Ngan H.Y.S., Choy K.W., Pang C.P., Poon C.S.P., Poon A.Y.A. and Ozcelik H., Recurrent BRCA1 and BRCA2 germline mutations in ovarian cancer: a founder mutation of BRCA1 identified in the Chinese population, Human Mutation. 2002, 19(3): 307-308.
Leung T.W., Cheung A.N.Y., Cheng D.K.L., Wong R.L.C. and Ngan H.Y.S., Expressions of c-erbB-2, epidermal growth factor receptor and pan-ras proto-oncogenes in adenocarcinoma of the cervix: Correlation with clinical prognosis, Oncology Reports. 2001, 8: 1159-1164.
Li H.W., Tsao G.S.W. and Cheung A.N.Y., Current understandings of the molecular genetics of gestational trophoblastic diseases, Placenta. 2002, 23: 20-31.
Liu S., Tsang B.K., Cheung A.N.Y., Xue W., Cheng D.K.L., Ng T.Y., Wong R.L.C. and Ngan H.Y.S., Anti-apoptotic proteins, apoptotic and proliferative parameters and their prognostic significance in cervical carcinoma, European Journal of Cancer. 2001, 37: 1104-1110.
Liu V.W.S., Shi H.H., Cheung A.N.Y., Chiu P.M., Leung T.W., Nagley P., Wong R.L.C. and Ngan H.Y.S., High incidence of somatic mitochondrial DNA mutations in human ovarian carcinomas, Cancer Research. 2001, 61: 5998-6001.
Ngan H.Y.S., Cheung A.N.Y., Liu S., Liu K.L. and Tsao G.S.W., Telomerase assay and HPV 16/18 typing as adjunct to conventional cytological cervical cancer screening, Tumor Biology. 2002, 23: 87-92.
Shek T.W.H., Chan G.C.F., Khong P.L., Chung L.P. and Cheung A.N.Y., Ewing Sarcoma of the Small Intestine, Journal of Pediatric Hematology/Oncology. 2001, 23(8): 530-532.
Wang X., Khoo U.S., Xue W. and Cheung A.N.Y., Cervical and peritoneal fluid cytology of uterine sarcomas, Acta Cytologica. 2002, 46(3): 465-469.
Xue W., Guan X.Y., Ngan H.Y.S., Shen D.H., Khoo U.S. and Cheung A.N.Y., Malignant placental site trophoblastic tumor: a cytogenetic study using comparative genomic hybridization and chromosome in situ hybridization, Cancer. 2002, 94(8): 2288-2294.


Researcher : Chiang AKS
Project Title:Experimental immunotherapy of tumours
Investigator(s):Dr. Chiang A.K.S.
Department:Paediatrics and Adolescent Medicine
Source(s) of Funding:Block Grant Earmarked for Research
Start Date:April 2001
Abstract:
To develop strategies in enhancing the host immune response against tumours.


Project Title:Immunstimulatory effects of different microbial components on maturation and differentiation of dendritic cell subsets
Investigator(s):Dr. Chiang A.K.S., Dr. Chan G.C.F., Dr. Lau A.S.Y.
Department:Paediatrics and Adolescent Medicine
Source(s) of Funding:Block Grant Earmarked for Research
Start Date:November 2001
Abstract:
To characterize the effects of different microbial components including nucleic acids on the maturation and survival of DC subsets, pDC1 and pDC2. The T cell polarization effect and the mechanisms of signal transduction would be further studied.


Researcher : Chiu PM
List of Research Outputs

Liu V.W.S., Shi H.H., Cheung A.N.Y., Chiu P.M., Leung T.W., Nagley P., Wong R.L.C. and Ngan H.Y.S., High incidence of somatic mitochondrial DNA mutations in human ovarian carcinomas, Cancer Research. 2001, 61: 5998-6001.


Researcher : Chow SNL
List of Research Outputs

Chow S.N.L., Investigation of Radio- and Chemosensitivity Mechanisms in Nasopharyngeal Carcinoma Cells (MPhil thesis). 2001.


Researcher : Chung LP
Project Title:Tissue specific expression and regulation of different splice variants of Vascular Endothelial Growth Factor (VEGF)
Investigator(s):Dr. Chung L.P., Dr. Leung S.Y., Dr. Wong M.P.
Department:Pathology (Hospital Pathology Services Morbid Anatomy/Cytology)
Source(s) of Funding:Block Grant Earmarked for Research
Start Date:July 1997
Abstract:
To determine the expression pattern of different splice variants of Vascular Endothelial Growth Factor (VEGF) in different cell types and to determine the regulation of this pattern by different modulators.


Project Title:Expression of angiopoietins and their receptor (Tie2) in tumours
Investigator(s):Dr. Chung L.P., Dr. Leung S.Y., Dr. Wong M.P., Dr. Yuen S.T.
Department:Pathology (Hospital Pathology Services Morbid Anatomy/Cytology)
Source(s) of Funding:Block Grant Earmarked for Research
Start Date:July 1998
Abstract:
To determine which members of the newly discovered gene family of angiopoietins are expressed in human tumours by Reverse Transcription-Polymerase Chain Reaction (RT-PCR); to identify the cellulr sources of angiopoietins in tumours by In Situ Hybridisation (ISH); to study the expression of Tie2 in tumours by RT-PCR and ISH; to compare the expression patterns of angiopoietins and Tie2, and determine the role of these molecules in tumour angiogenesis.


List of Research Outputs

Chim J.C.S., Loong F. and Chung L.P., Chronic Lymphocytic Leukemia involving the Gallbladder, British Journal of Haematology. 2002, 115: 717.
Chim J.C.S., Shek T.W.H., Chung L.P. and Ho J.C.Y., Gut perforation in MALToma of colon, Haematologica. 2002, 87(4): EIM15.
Chim J.C.S., Wong W.M., Nicholls J.M., Chung L.P. and Liang R.H.S., Hemorrhagic Gastric plasmacytoma as the Primary Presentation in Multiple myeloma., Journal of Clinical Oncology. 2002, 20: 344-347.
Chim J.C.S., Liang R.H.S., Loong F. and Chung L.P., Primary MALT lymphoma of the Gallbladder, American Journal of Medicine. 2002, 112(6): 151-157.
Shek T.W.H., Chan G.C.F., Khong P.L., Chung L.P. and Cheung A.N.Y., Ewing Sarcoma of the Small Intestine, Journal of Pediatric Hematology/Oncology. 2001, 23(8): 530-532.


Researcher : Collins RJ
Project Title:Molecular genetics in gastrointestinal polyposis syndrome
Investigator(s):Dr. Collins R.J., Dr. Chung L.P., Dr. Ho J.W.C., Dr. Yuen S.T.
Department:Pathology (Hospital Pathology Services Morbid Anatomy/Cytology)
Source(s) of Funding:Block Grant Earmarked for Research
Start Date:July 1998
Abstract:
To define the molecular genetic changes in three polyposis syndromes; to establish methods for efficiency screening of at-risk individuals within these families.


Project Title:High risk HPV subtypes other than the more common HPV 16 and 18 subtypes in Hong Kong
Investigator(s):Dr. Collins R.J., Dr. Chung L.P.
Department:Pathology (Hospital Pathology Services Morbid Anatomy/Cytology)
Source(s) of Funding:Block Grant Earmarked for Research
Start Date:July 1999
Abstract:
To determine the incidence of HPV 31, 33, 35 and 45 in cervical cancer and in atypical cervical cytological specimens.


Researcher : Fong PY
List of Research Outputs

Fong P.Y., Differential Gene Expression in Gestational Trophoblastic Disease (MPhil thesis). 2001.


Researcher : Fung LF
List of Research Outputs

Au W.Y., Ma E.S.K., Chan L.C., So C.K.C., Fung L.F. and Shek T.W.H., Chromosome 11q deletion in myeloid malignancies, Leukemia and Lymphoma. 2002, 16: 953-955.
Ma E.S.K., Wan T.S.K., Au W.Y., Fung L.F., So C.K.C. and Chan L.C., Chromosome 11q deletion in myeloid malignancies, Leukemia. 2001, 16: 953-955.


Researcher : Hawkins BR
Project Title:Maintenance of a bone marrow donor registry
Investigator(s):Dr. Hawkins B.R.
Department:Pathology (Hospital Pathology Services Immunology)
Source(s) of Funding:Hong Kong Marrow Match Foundation
Start Date:January 1992
Abstract:
To study maintenance of a bone marrow donor registry.


List of Research Outputs

Au W.Y., Hawkins B.R., Lie A.K.W., Kung A.W.C., Kwong Y.L., Liang R.H.S. and Chan E.Y.T., Association of the HLA A2-B46-DR9 haplotype with atutoimmune thyroid dysfunction after bone marrow transplantation in Chinese patients., British Journal of Haematology. 2001, 115: 660-663.
Au W.Y., Lo C.M., Hawkins B.R., Ma E.S.K., Lie A.K.W. and Kwong Y.L., Evans' syndrome complicating chronic graft versus host disease after cadaveric liver transplantation, Transplantation. 2001, 72(3): 527-528.
Au W.Y., Lie A.K.W., Kwong Y.L., Shek T.W.H., Hawkins B.R., Lai K.N., Tang S.C.W., Lo C.M., Fan S.T., Liu C.L., Chan G.C.F., Chau M.C., Chiu S.W. and Liang R.H.S., Post-transplantation lymphoproliferative disease in Chinese: the Queen Mary Hospital experience in Hong Kong, Leukemia and Lymphoma. 2002, 43: 1405-1409.
Au W.Y., Hawkins B.R., Cheng N., Lie A.K.W., Liang R.H.S. and Kwong Y.L., Risk of haematologic malignancies in HLA B27 carriers, British Journal of Haematology. 2001, 115: 320-322.
Zhou X., Ha S.Y., Chan G.C.F., Luk C.W., Chan V.N.Y., Hawkins B.R., Lam Y.H., Liang R.H.S. and Lau Y.L., Successful mismatched sibling cord blood transplant in Hb Bart's disease, Bone Marrow Transplantation. 2001, 28: 105-107.


Researcher : Higgins DA
Project Title:Molecular and phenotypic analysis of duck T and B lymphoblastoid cell lines
Investigator(s):Dr. Higgins D.A., Dr. Cheng S.H., Prof. Warr G.W.
Department:Pathology
Source(s) of Funding:Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:September 1998
Abstract:
To define the gene reorganizations that occur in the duck Ig H chain locus during the transcription and expression of Mu, Upsilon, Upsilon(~Fc) and Alpha H chain isotypes; to complete our repertoire of genetic and serological reagents defining the duck T and B cell phenotypes and subpopulations; to apply the reagents to studies of the anatidine immune system during development and in disease.


Project Title:Epidemiology of melioidosis in an oceanarium: a clinical, environmental and molecular study
Investigator(s):Dr. Higgins D.A., Dr. Kinoshita R.
Department:Pathology
Source(s) of Funding:Block Grant Earmarked for Research
Start Date:November 2000
Abstract:
(1) A descriptive epidemiological investigation of melioidosis in Ocean Park since 1975 using available data/records and pathological examination of archived tissues. (2) Environmental isolation of Burkholderia pseudomallei to define its prevalence and source within the oceanarium and perhaps extending to other areas within Hong Kong. (3) Molecular and phenotypic characterization of recent and archival clinical and enivornmental isolates from Ocean Park and other local isolates to compare and contrast strains from different species and sources.


Project Title:Evolution of the lymphocyte surface: identification and characterization of duck T cell xenoantigens
Investigator(s):Dr. Higgins D.A., Dr. Opstelten D., Prof. Warr G.W.
Department:Pathology
Source(s) of Funding:Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:January 2001
Abstract:
To complete the molecular characterization of the surface structures on duck T lymphocytes recognized by rabbit or mouse antisera.


Project Title:Monoclonal antibodies specific for duck t lymphocyte surface antigens
Investigator(s):Dr. Higgins D.A.
Department:Pathology
Source(s) of Funding:Block Grant Earmarked for Research
Start Date:November 2001
Abstract:
To determine, by cell sorting and RT-PCR analysis, the T cell phenotype specificities of panels of mouse moabs raised against duck TcRalfa/Beta or TcR(alpha)/(delta) cell lines.


List of Research Outputs

Kinoshita R.E. and Higgins D.A., Melioidosis in captive marine mammals and birds, Journal of the Japan Veterinary Medical Association . 2001, 54(9): 748-750.


Researcher : Ho JCY
List of Research Outputs

Chim J.C.S., Shek T.W.H., Chung L.P. and Ho J.C.Y., Gut perforation in MALToma of colon, Haematologica. 2002, 87(4): EIM15.
Wong B.C.Y., Lam S.K., Wong W.M., Zheng T., Chen J.S., Chen B.W., Lai K.C., Yuen S.T. and Ho J.C.Y., Eradicating Helicobacter pylori infection in general population prevents gastric cancer: 1 7 year prospective randomized placebo-controlled study, Gastroenterology. 2002, 122 (4 suppl 1): A588.
Wong B.C.Y., Lam S.K., Wong W.M., Feng R.E., Zheng T., Yuen S.T., Ho J.C.Y., Leung S.Y., Chen J.S. and Lai K.C., Eradication of Helicobacter pylori infection significantly slows down the progression of precancerous lesions in high risk population: a 5-year prospective randomized study, Gastroenterology. 2002, 122 (4 suppl 1): A588.


Researcher : Hu Y
List of Research Outputs

Hu Y., Lam A.K.Y., Law S., Wong J. and Srivastava G., Identification of differentially expressed genes in esophageal squamous cell carcinoma (ESCC) by cDNA expression array: overexpression of Fra-1, Neogenin, Id-1, and CDC25B genes in ESCC, Clinical Cancer Research. 2001, 7: 2213-2221.
Hu Y., Lam K.Y., Law S.Y.K., Wan T.S.K., Ma E.S.K., Kwong Y.L., Chan L.C., Wong J. and Srivastava G., Establishment, characterization, karyotyping, and comparative genomic hybridization analysis of HKESC-2 and HKESC-3: two newly established human esophageal squamous cell carcinoma cell lines, Cancer Genetics and Cytogenetics. 2002, 135: 120-127.
Hu Y., Molecular Pathogenesis of Oesophageal Squamous Cell Carcinoma (PhD thesis). 2001.


Researcher : Huang F
Project Title:Tracking, visualizing and characterization of normal and "auto-reactive" T and B cells in steady state and in "danger"
Investigator(s):Dr. Huang F.P., Dr. MacPherson G.G.
Department:Pathology
Source(s) of Funding:Block Grant Earmarked for Research
Start Date:February 2001
Completion Date:January 2002
Abstract:
To study mechanisms of peripheral tolerance by tracking adoptively transferred labeledT and B cells in semi-allogeneic and syngeneic rat models; to determine the effects of inflammatory stimuli on antigen presenting cells and immune effector T andB lymphocytes both in normal and in "auto-reactive" situations; to compare dendritic cell (DC) functions and allogeneic T and B cell responses between conventional and specific pathogen free (SPF) animals; to compare cytokine expression profiles (IL-10, IL-12, IFN-gamma, TGF-beta etc.) of proliferating and non-proliferating CD8+ and CD4+ T cells, and of host APC, after co-injection of bacterial product (LPS) into the animals; to characterize and to compare cells with T regulatory (Treg) phenotypes generated in the semi-allogeneic and syngeneic models after cell transfer under steady state and in the presence of inflamatory stimuli.


Project Title:The roles of regulatory dendritic cells in peripheral tolerance and autoimmunity
Investigator(s):Dr. Huang F.P., Dr. MacPherson G.G.
Department:Pathology
Source(s) of Funding:Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:September 2001
Abstract:
To create in vivo models which mimic and auto- or host-reactive environment; to visualise the fate of potential self-reactive T cells in normal and in autoimmune-prone mice; to study the role of DCreg in the generation of Treg cells; to study DC functions in autoimmune models; to generate DCreg and Treg for the treatment of autoimmune diseases.


Project Title:Effects of uptake of apoptotic and necrotic cells by dendritic cells (DC) on anti-nuclear antibody production in normal and in lupus prone mouse models
Investigator(s):Dr. Huang F.P., Dr. Wu A.Y.Y.
Department:Pathology
Source(s) of Funding:Block Grant Earmarked for Research
Start Date:November 2001
Completion Date:April 2002
Abstract:
To test the hypothesis that uptake of dying cells by DC may trigger anti-nuclear auto-antibody (ANA) responses in normal and autoimmune mouse models; to compare the effects of cell death by apoptosis and by necrosis on the induction of ANA responses; to determine the effect of apoptotic cell uptake load on DC immunogenicity in the induction of autoantibody responses; to determine whether uptake of necrotic or apoptotic dying cells by DC may accelerate or down-regulate respectively autoimmune responses in the lupus prone mice.


List of Research Outputs

Esfandiari E., McInnes I.B., Lindop G., Huang F., Field M., Komai-Koma M., Wei X.Q. and Liew F.Y., A proinflammatory role of IL-18 in the development of spontaneous autoimmune disease, The Journal of Immunology. 2001, 167: 5338-5347.
Huang F., Farquhar C.F., Mabbott N.A., Bruce M.E. and MacPherson G.G., Migrating intestinal dendritic cells transport PrPSc from the gut, Journal of General Virology. 2002, 83(1): 267-271.
MacPherson G., Wykes M., Huang F. and Jenkins C., Isolation of dendritic cells from rat intestinal lymph and spleen, Methods in Molecular Medicine: Dendritic Cell Protocols. Humana Press, 2001, Part I, Chapter 4: 64.
MacPherson G.G., Huang F. and Liu L.M., Intestinal dendritic cells, Dendritic Cells (2nd edition) - Biology and Clinical Applications. Academic Press, 2001, Chapter 25: 325-336.


Researcher : Jones BM
List of Research Outputs

Au W.Y., Chan H.H.L., Jones B.M., Ng W.M. and Yeung C.K., Recurrent pyoderma gangrenosum and myelodysplasia, Haematologica. 2001, 86: 32.


Researcher : Khoo US
Project Title:The role of BRCA1 and BRCA2 genes in the pathogenesis of sporadic ovarian cancer
Investigator(s):Dr. Khoo U.S., Dr. Cheung A.N.Y., Prof. Ngan H.Y.S.
Department:Pathology
Source(s) of Funding:Block Grant Earmarked for Research
Start Date:November 2000
Completion Date:October 2002
Abstract:
To investigate whether mechanisms involving the BRCA1 and BRCA2 genes other than coding region mutations might be involved in ovarian carcinogenesis.


Project Title:Her2 overxpression and amplification analysis by real-time polymerase chain reaction, immunhistochemical and in-situ hybridization methods
Investigator(s):Dr. Khoo U.S., Dr. Cheung A.N.Y.
Department:Pathology
Source(s) of Funding:Block Grant Earmarked for Research
Start Date:November 2001
Abstract:
To evaluate the HER2 overexpression and amplification status of breast and ovarian cancer from fine needle aspiration and touch preparation samples by the use of real-time polymerase chain reaction and to compare these results with those obtained by immunohistochemical and in-situ hybridization methods.


List of Research Outputs

Khoo U.S., Chan Y.K., Cheung A.N.Y., Xue W., Shen D.H., Fung K.Y., Ngan H.Y.S., Choy K.W., Pang C.P., Poon C.S.P., Poon A.Y.A. and Ozcelik H., Recurrent BRCA1 and BRCA2 germline mutations in ovarian cancer: a founder mutation of BRCA1 identified in the Chinese population, Human Mutation. 2002, 19(3): 307-308.
Wang X., Khoo U.S., Xue W. and Cheung A.N.Y., Cervical and peritoneal fluid cytology of uterine sarcomas, Acta Cytologica. 2002, 46(3): 465-469.
Xue W., Guan X.Y., Ngan H.Y.S., Shen D.H., Khoo U.S. and Cheung A.N.Y., Malignant placental site trophoblastic tumor: a cytogenetic study using comparative genomic hybridization and chromosome in situ hybridization, Cancer. 2002, 94(8): 2288-2294.


Researcher : Kinoshita RE
List of Research Outputs

Brook F.M., Kinoshita R.E. and Benirschke K., Histology of the ovaries of a bottlenose dolphin, TURSIOPS ADUNCUS, of known reproductive history, Marine Mammal Science. 2002, 18(2): 540-544.
Ho P.L., Cheung K.M., Kinoshita R.E., Tse C.W.S., Yuen K.Y. and Chau P.Y., Activity of five fluoroquinolones against 71 isolates of Burkholderia pseudomallei, Journal of Antimicrobial Chemotherapy. 2002, 49: 1039-1046.
Kinoshita R.E. and Higgins D.A., Melioidosis in captive marine mammals and birds, Journal of the Japan Veterinary Medical Association . 2001, 54(9): 748-750.


Researcher : Lam AKY
List of Research Outputs

Hu Y., Lam A.K.Y., Law S., Wong J. and Srivastava G., Identification of differentially expressed genes in esophageal squamous cell carcinoma (ESCC) by cDNA expression array: overexpression of Fra-1, Neogenin, Id-1, and CDC25B genes in ESCC, Clinical Cancer Research. 2001, 7: 2213-2221.
Hu Y.C., Lam A.K.Y., Law S., Wong J. and Srivastava G., Profiling of differentially expressed cancer-related genes in esophageal squamous cell carcinoma (ESCC) using human cancer cDNA arrays: overexpression of oncogene MET correlates with tumor differentiation in ESCC, Clinical Cancer Research. 2001, 7: 3519-3525.
Lam A.K.Y. and Lo C.Y., Adrenal lipomatous tumours: a 30 year clinicopathological experience at a single institution, Journal of Clinical Pathology. 2001, 54: 707-712.


Researcher : Lam CCK
List of Research Outputs

Au W.Y., Lam C.C.K. and Jim M.H., An unusual case of coronary artery disease in a patient with Christmas disease, American Journal of Hematology. 2002, 69: 152-153.
Au W.Y., Lo C.M., Liu C.L., Fan S.T. and Lam C.C.K., Life threatening ABO mediated hemolysis after cadaveric orthotopic liver transplantation, Transplantation. 2002, 74: 285-286.
Chim J.C.S., Lam C.C.K. and Chan T.K., Hemighost cell in acute hepatitis A., American Journal of Medicine. 2001, 111: 81-82.


Researcher : Lam KY
List of Research Outputs

Lam K.Y., Lo C.Y., Shek T.W.H., Ma E.S.K., Au W.Y. and Chan G.C.F., Primitive small round cell tumour of the adrenal gland presenting with fever of unknown origin and t(12;22) (q13;q12) cytogenetic finding, Journal of Clinical Pathology. 2002, 54: 966-970.
Lam K.Y., Expression of EEN (Endophilin II), a fusion partner gene in leukemia, in haemopoietic cells, MPhil Thesis. 2002.


Researcher : Lee CK
List of Research Outputs

Au W.Y., Lie A.K.W., Lee C.K., Ma E.S.K., Wan T.S.K., Shek T.W.H., Liang R.H.S. and Kwong Y.L., Late onset post-transplantation lymphoproliferative disease of recipient origin following cytogenetic relapse and occult autologous haematopoietic regeneration after allogeneic bone marrow transplantation for acute myeloid leukaemia, Bone Marrow Transplantation. 2001, 28(4): 417-419.


Researcher : Lee MF
List of Research Outputs

Chan K.L., Lee M.F., Guan X.Y., Fan S.T. and Ng I.O.L., High-density allelotyping of chromosome 8p in hepatocellular carcinoma and clinicopathologic correlation, Cancer. 2002, 94(12): 3179-3185.
Ng I.O.L., Poon R.T.P., Lee M.F., Fan S.T., Ng M.M.T. and Tso W.K., Microvessel density, vascular endothelial growth factor and its receptors Flt-1 and Flk-1/KDR in hepatocellular carcinoma, American Journal of Clinical Pathology. 2001, 116: 838-845.


Researcher : Lee MY
List of Research Outputs

Lee M.Y., Analysis on chromosome 3p in smokers and non-smokers with non-small cell lung carcinoma, MPhil Thesis. 2002.


Researcher : Leung SY
Project Title:Aberrant promoter hypermethylation of growth regulatory genes in cancers of the gastro-intestinal tract
Investigator(s):Dr. Leung S.Y., Dr. Chu K.M., Dr. Chung L.P.
Department:Pathology
Source(s) of Funding:Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:October 1999
Abstract:
To investigate the importance of aberrant promoter methylation of growth regulatory genes in the carcinogenesis of gastro-intestinal tract cancers.


Project Title:Genetic instability in early onset colorectal cancer in Hong Kong Chinese
Investigator(s):Dr. Leung S.Y., Dr. Chung L.P., Dr. Ho J.W.C., Prof. Wyllie A.H., Dr. Yuen S.T.
Department:Pathology
Source(s) of Funding:Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:October 2000
Abstract:
To examine a large cohort o fyoung patients for microsatellite instability (MSI) and mismatch repair (MMR) gene mutation. Results obtained on MMR gene will help to formulate strategy for mutation detection, prophylactic screening and management of young MSI colorectal cancer (CRC) patients and particularly their family members.


Project Title:Identification of growth regulatory genes as targets of inactivation by microsatellite instability in various organs
Investigator(s):Dr. Leung S.Y., Dr. Yuen S.T.
Department:Pathology
Source(s) of Funding:Block Grant Earmarked for Research
Start Date:November 2000
Abstract:
To look for frameshift mutation in various growth regulatory genes harbouring repeat sequences in their coding region, of microsatellite unstable (MSI) colorectal, gastric and brain cancers.


Project Title:Haplotype analysis of recurrent germline mutations in DNA mismatch repair genes in Hong Kong Chinese - a search for founder mutations
Investigator(s):Dr. Leung S.Y., Dr. Yuen S.T.
Department:Pathology
Source(s) of Funding:Block Grant Earmarked for Research
Start Date:November 2001
Abstract:
To perform haplotype analysis on unrelated kindreds with the same germline MMR gene mutation, to explore the possibility of a founder effect.


Project Title:Identification of novel differentially expressed genes in gastric cancer and their functional characterisation
Investigator(s):Dr. Leung S.Y., Dr. Chu K.M., Prof. Kung H.F., Dr. Lin M.C.M., Dr. Yuen S.T.
Department:Pathology
Source(s) of Funding:Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:December 2001
Abstract:
To identify and isolate partial cDNA sequences of genes that are differentially-expressed in various stages of gastric carcinogenesis using combined supression subtractive hybridisation and cDNA microarrays; to study cloning of full length cDNA sequences for novel genes; to study expression analysis of these genes in the mRNA and protein level in a large panel of gastric cancers, and examine their relationaship with clinico-pathological parameters, association with aetiological agents, molecular genetic changes, prognosis, response to treatment and their potential use as tujour markers; to study functional characterisation of these novel genes, with regard to their effects in cell division, mitotic activity, tranforming activity, tumourigenicity, roles in cell cycle control, apoptosis, and relationship with other signal trnsduction pathways.


List of Research Outputs

Davies H., Bignell G.R., Cox C., Stephens P., Edkins S., Clegg S., Teague J., Woffendin H., Garnett M.J., Bottomley W., Davis N., Dicks E., Ewing R., Floyd Y., Gray K., Hall S., Hawes R., Hughes J., Kosmidou V., Menzies A., Mould C., Parker A., Stevens C., Watt S., Hooper S., Wilson R., Jayatilake H., Gusterson B.A., Cooper C., Shipley J., Hargrave D., Pritchard-Jones K., Maitland N., Chenevix-Trench G., Riggins G.J., Bigner D.D., Palmieri G., Cossu A., Flanagan A., Nicholson A., Ho J.W.C., Leung S.Y., Yuen S.T., Weber B.L., Seigler H.F., Darrow T.L., Paterson H., Marais R., Marshall C.J., Wooster R., Stratton M.R. and Futreal P.A., Mutations of the BRAF gene in human cancer, Nature. 2002, 417: 949-954.
Fan X.M., Wong B.C.Y., Zhou X.M., Wang W.P., Lin M.C., Kung H., Yuen S.T., Leung S.Y. and Lam S.K., Inhibition of proteasome function induced apoptosis in gastric cancer cells, International Journal of Cancer. 2001, 93(4): 481-8.
Lin M.C., Deng Y.C., Liu X., Wang J., Leung S.Y., Kung H. and Yao L., Characterization of the N-myc downstream regulated gene 2 in human glioblastoma, Dissecting cancer through genome research. May 2002, Dublin, Ireland. Oncogenomics. 2002.
Wong B.C.Y., Lam S.K., Wong W.M., Feng R.E., Zheng T., Yuen S.T., Ho J.C.Y., Leung S.Y., Chen J.S. and Lai K.C., Eradication of Helicobacter pylori infection significantly slows down the progression of precancerous lesions in high risk population: a 5-year prospective randomized study, Gastroenterology. 2002, 122 (4 suppl 1): A588.
Wong W.M., Wong B.C.Y., Tang V.S., Lai K.C., Yuen S.T., Leung S.Y. and Hu H.C., An evaluation of the PyloriTek test for the diagnosis of Helicobacter pylori infection in Chinese patients before and after eradication therapy, Journal of Gastroenterology and Hepatology. 2001, 16(9): 976-980.
Xia H.H.X., Wong B.C.Y., Huang X.R., He X.X., Wong W.M., Leung S.Y., Yuen S.T., Lan H.Y. and Lam S.K., Expression of macrophage migration inhibitory factor in Helicobacter pylori induced gastritis and peptic ulcer disease, The Hong Kong Practitioner. 2002, 24 (2 suppl): 41.


Researcher : Liang ACT
List of Research Outputs

Shen L., Liang A.C.T., Au W.Y., Liang R.H.S. and Srivastava G., Somatic mutation of Fas gene is a common event in nasal NK/T cell lymphomas. "Lymphoma: the Next Question"., MD Anderson Cancer Center Houston, Texas, USA.. 2001.


Researcher : Loong F
List of Research Outputs

Chim J.C.S., Loong F. and Chung L.P., Chronic Lymphocytic Leukemia involving the Gallbladder, British Journal of Haematology. 2002, 115: 717.
Chim J.C.S., Liang R.H.S., Loong F. and Chung L.P., Primary MALT lymphoma of the Gallbladder, American Journal of Medicine. 2002, 112(6): 151-157.


Researcher : Lu L
Project Title:The role of caspases during B cell apoptosis
Investigator(s):Dr. Lu L.W.
Department:Pathology
Source(s) of Funding:Block Grant Earmarked for Research
Start Date:November 2000
Abstract:
To examine: a) the role of caspases during B cell apoptosis; b) the regulation of caspase activation in B cell death.


Project Title:The regulatory role of tumor suppressor gene Pten in B cell development and neoplasia
Investigator(s):Dr. Lu L.W., Prof. Wu G.E.
Department:Pathology
Source(s) of Funding:Block Grant Earmarked for Research
Start Date:November 2001
Abstract:
To examine the role of Pten in regulating B cell growth and survival; to examine the effect of Pten insufficiency on B cell development and neoplasia in Pten +/- mice


Researcher : Ma ESK
Project Title:Characterisation of complex and cryptic cytogenetic changes in leukaemia by multicolour karyotyping
Investigator(s):Dr. Ma E.S.K., Prof. Chan L.C., Dr. Wan T.S.K.
Department:Pathology
Source(s) of Funding:Block Grant Earmarked for Research
Start Date:November 2000
Abstract:
To employ the new technique of multicolour karyotyping to decipher complex cytogenetic abnormalities in leukaemia, to characterise marker chromosomes, and to detect subtle or cryptic cytogenetic changes.


Project Title:Telomere shortening and lineage chimerism in bone marrow transplantation
Investigator(s):Dr. Ma E.S.K.
Department:Pathology
Source(s) of Funding:Block Grant Earmarked for Research
Start Date:November 2001
Abstract:
To determine the rate of telomere length shortening post-BMT with respect to age-related telomere shortening in normal individuals, in whole blood and in different cellular compartments; to correlate results with lineage chimerism data; to analyze the relationship between telomere shortening to source of stem cell, cell dose and conditioning regimen.


List of Research Outputs

Au W.Y., Kwong Y.L. and Ma E.S.K., Acute myeloid leukemia after Dengue fever in a patient with Hemoglobin H disease, Haematologica. 2001, 86: E17.
Au W.Y., Ma E.S.K., Chan L.C., So C.K.C., Fung L.F. and Shek T.W.H., Chromosome 11q deletion in myeloid malignancies, Leukemia and Lymphoma. 2002, 16: 953-955.
Au W.Y., Yuen M.F., Lai K.C., Wan T.S.K. and Ma E.S.K., Clonal marrow abnormalities after azathioprine and sulphasalazine exposure in Crohn's disease: a cautionary tale, Leukemia and Lymphoma. 2002, 43: 1679-1681.
Au W.Y., Ma E.S.K. and Kwong Y.L., Disseminated hepatosplenic mycobacterial infection masking myeloproliferative diseases as leukemoid reaction: a diagnostic pitfall, Leukemia and Lymphoma. 2001, 42(4): 805-808.
Au W.Y., Lo C.M., Hawkins B.R., Ma E.S.K., Lie A.K.W. and Kwong Y.L., Evans' syndrome complicating chronic graft versus host disease after cadaveric liver transplantation, Transplantation. 2001, 72(3): 527-528.
Au W.Y., Ma E.S.K., Lie A.K.W., Liang R.H.S., Cheng T. and Kwong Y.L., Glucose-6-phosphate dehydrogenase deficiency and hematopoietic stem cell transplantation, Bone Marrow Transplantation. 2002, 29(5): 399-402.
Au W.Y., Ma E.S.K. and Wong K.K., Hyposplenism after allogeneic bone marrow transplantation., British Journal of Haematology. 2002, 117: 488.
Au W.Y., Kwong Y.L. and Ma E.S.K., Intravenous pentamidine induced megaloblastic anemia, Haematologica. 2002, 87: ECR06.
Au W.Y., Lie A.K.W., Lee C.K., Ma E.S.K., Wan T.S.K., Shek T.W.H., Liang R.H.S. and Kwong Y.L., Late onset post-transplantation lymphoproliferative disease of recipient origin following cytogenetic relapse and occult autologous haematopoietic regeneration after allogeneic bone marrow transplantation for acute myeloid leukaemia, Bone Marrow Transplantation. 2001, 28(4): 417-419.
Au W.Y., Kwong Y.L. and Ma E.S.K., Myeloproliferatie disease masquerading as leukemoidreaction secondary to disseminated mycobacterial infection, Leukemia and Lymphoma. 2001, 42: 805-808.
Au W.Y., Lie A.K.W., Ma E.S.K., Wan T.S.K., Liang R.H.S., Leung A.Y.H. and Kwong Y.L., Philadelphia (Ph) chromosome-positive chronic myeloid leukaemia relapsing as Ph-negative leukaemia after allogeneic bone marrow transplantation, British Journal of Haematology. 2001, 114(2): 365-368.
Au W.Y., Ma E.S.K., Wan T.S.K., Man C.W.Y., Kwong Y.L. and Jim M.H., Pulmonary stenosis, demyelination and myelodysplasia with monosomy 7, Leukemia and Lymphoma. 2002, 43: 1509-1511.
Chim J.C.S. and Ma E.S.K., Acute biphenotypic leukaemia, Haematologica. 2002, 87(1): EIM03.
Chim J.C.S., Au W.Y., Liang R.H.S., Kwong Y.L., Shek T.W.H., Ma E.S.K., Ho J.C.C. and Tung H.M., Primary CD56 positive lymphomas of the fastrointestinal tract, Cancer. 2001, 91: 523-533.
Ha S.Y., Chan G.C.F., Ma E.S.K., Kwong Y.L., Liang R.H.S. and Lau Y.L., Treatment outcome and chimerism status after cord blood or bone marrow transplant in transfusion dependent thalassaemia patients., Annual meeting of European Bone Marrow Transplant Registry.. 2002, 561.
Ha S.Y., Chan G.C.F., Ma E.S.K., Liang R.H.S., Kwong Y. and Lau Y.L., Treatment outcome and chimerism status after cord blood or bone marrow transplant in transfusion-dependent thalassaemia patients, 28th Annual Meeting of the European Group for Blood and Marrow Transplantation, Montreux, Switzerland, 24-27 March 2002.
Hu Y., Lam K.Y., Law S.Y.K., Wan T.S.K., Ma E.S.K., Kwong Y.L., Chan L.C., Wong J. and Srivastava G., Establishment, characterization, karyotyping, and comparative genomic hybridization analysis of HKESC-2 and HKESC-3: two newly established human esophageal squamous cell carcinoma cell lines, Cancer Genetics and Cytogenetics. 2002, 135: 120-127.
Lam K.Y., Lo C.Y., Shek T.W.H., Ma E.S.K., Au W.Y. and Chan G.C.F., Primitive small round cell tumour of the adrenal gland presenting with fever of unknown origin and t(12;22) (q13;q12) cytogenetic finding, Journal of Clinical Pathology. 2002, 54: 966-970.
Lie A.K.W., Au W.Y., Ma E.S.K., Wan T.S.K., Liang R.H.S. and Kwong Y.L., Tynsine kinase inhibitor ST1571 in teaching Philadelphia chromosome positive leukemic relapsing from myeloablastive allogeneic., 43rd Annual Meeting of American Society of Hematology, Orlando, USA.. 2001.
Ma E.S.K., Lee A.C.W., Chan A.Y.Y. and Chan L.C., A novel A ATAAA--> C ATAAA mutation at the polyadenylation site of the b-globin gene, British Journal of Haematology. 2001, 115(1): 230-231.
Ma E.S.K., Wan T.S.K., Au W.Y., Fung L.F., So C.K.C. and Chan L.C., Chromosome 11q deletion in myeloid malignancies, Leukemia. 2001, 16: 953-955.
Ma E.S.K., Chan A.Y.Y., Chiu E.K.W. and Chan L.C., Haemoglobin H disease due to (--SEA) a-globin gene deletion and a2-codon 30 (DGAG) mutation: a family study, Clinical and Laboratory Haematology. 2001, 23(5): 325-327.
Ma E.S.K., Chow E.Y.D., Chan A.Y.Y., Chu C.M., Lin S.Y. and Chan L.C., Low affinity and unstable hemoglobin variant caused by AAC->ATC (Asn->Ile) mutation at codon 108 of the b-globin gene, Haematologica. 2002, 87(5): 553-554.
Ma E.S.K., Chan Y.Y.A., Ha S.Y., Lau Y.L. and Chan L.C., Thalassaemia screening based on red cell indices in the Chinese, Haematologica. 2001, 86: 1310-1311.
Ma E.S.K., Chan L.C., Ha S.Y., Chan G.C.F., Chan A.Y. and Au W.Y., The (--SEA) alpha- thalassemia deletion ameliorates the clinical phenotype of beta Zero/beta plus thalassaemia but no necessarily beta zero/beta zero thalassaemia, Haematologica. 2002, 87: 4333-444.
Ma E.S.K., Chan A.Y.Y., Ha S.Y., Chan G.C.F., Au W.Y. and Chan L.C., The (--SEA) a-thalassemia (SEA) deletion ameliorates the clinical phenotype of b0 / b+ but not necessarily that of b0 / b0 thalassemia, Haematologica. 2001, 87(4): 443-444.
Wan T.S.K., Ma E.S.K., Ho M.Y., Chan L.C., Yip S.F., Wong L.G. and Yeung Y.M., Cytogenetic biclonality in polycythemia vera: unusual and unrelated clones, Cancer Genetics and Cytogenetics. 2001, 131(1): 86-89.
Wan T.S.K., Yip S.F., Yeung Y.M., Chan L.C. and Ma E.S.K., Fatal diffuse alveolar damage complicating acute myeloid leukemia with abnormal eosinophils and trisomy X, Annals of Hematology. 2002, 81: 167-169.


Researcher : Nanji AA
Project Title:Cyclooxygenase-2 in inflammatory and fibrotic liver disease
Investigator(s):Prof. Nanji A.A.
Department:Pathology
Source(s) of Funding:Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:September 2000
Abstract:
To ameliorate liver injury by inhibitors of cyclooxygenase-2. The inhibitors of cyclooxygenase-2 used will include an enzyme already approved for clinical use for rheumatoid arthritis, and other traditional Eastern and Chinese herbal medicines used for treatment of inflammation and liver injury.


List of Research Outputs

Jokelaine K., Reinke L.A. and Nanji A.A., NF-KB activation is associated with free radical generation and endotoxemia and precedes pathological liver injury in experimental alcoholic liver disease, Viral. 2001, 16(1): 36-39.
Lau G., Leung A.Y.H., Au W.Y., Kwong Y.L., Lie A.K.W., Liang R.H.S., Hou J., Nanji A.A. and Fong D.Y.T., High HBV DNA viral load is the most significant risk factor for hepatitis B reactiation in hepatitis B surface antign positive patients treated with autologous hematopoietic stem cell transplantation, Blood. 2002, 99: 2324-2330.
Lau G., Suri D., Liang R.H.S., Rigopoulou E.I., Thomas M.G., Mullerova I., Nanji A.A., Yuen S.T., Williams R. and Naoumov N.V., Resolution of chronic hepatitis B and anti-HBs seroconversion in humans by adoptive transfer of immunity to hepatitis B core antigen, Gastroenterology. 2002, 122(3): 614-624.
Lau G., Nanji A.A., Hou J., Fong D.Y.T., Au W.S., Yuen S.T. and Lin M.C., Thymosin-a1 and famciclovir combination therapy activates T-cell response in patients with chronic hepatitis B virus infection in immune-tolerant phase, Journal of Viral Hepatitis. 2002, 9: 280-287.
Lau G.K.K., Leung A.Y.H., Fong D.Y.T., Au W.Y., Kwong Y.L., Lie A.K.W., Hou J.L., Wen Y.M., Nanji A.A. and Liang R.H.S., High hepatitis B virus (HBV) DNA viral load as the most important risk factor for HBV reactivation in patients positive for HBV surface antigen undergoing autologous hematopoietic cell transplantation, Blood. 2002, 99: 2324-2330.
Nanji A.A., Jokelainen K., Lau G., Rahemtulla A., Tipoe G.L., Polavarapu R. and Lalani E.N., Arginine reverses ethanol-induced inflammatory and fibrotic changes in liver despite continued ethanol administration, Journal of Pharmacology and Experimental Therapeutics. 2001, 299(3): 832-839.
Nanji A.A., Jokelainen K., Tipoe G.L., Rahemtulla A. and Dannenberg A.J., Dietary saturated fatty acids reverse inflammatory and fibrotic changes in rat liver despite continued ethanol administration, Journal of Pharmacology and Experimental Therapeutics. 2001, 299(2): 638-644.
Nanji A.A., Jokelainen K., Fotouhinia M., Rahemtulla A., Thomas P., Tipoe G.L., Su G.L. and Dannenberg A.J., Increased severity of alcoholic liver injury in female rats: role of oxidative stress, endotoxin, and chemokines, American Journal of Physiology. Gastrointestinal and Liver Physiology. 2001, 281(6): 1348-1356.
Nanji A.A., Lau G., Tipoe G.L., Yuen S.T., Chen Y.X., Thomas P. and Lan H.Y., Macrophage migration inhibitory factor expression in male and female ethanol-fed rats, Journal of Interferon and Cytokine Research. 2001, 21(12): 1055-1062.
Nanji A.A., SU G.L., Laposata M. and French S.W., Pathogenesis of alcoholic liver disease-recent advances, Alcoholism, Clinical and Experimental Research. 2002, 26(5): 731-736.
Nanji A.A., Role of Kupffer cells in alcoholic hepatitis, Alcohol. 2002, 27(1): 13-15.
Yagi Y., Kuwahara M., Nanji A.A., Birumachi J., Nishibata R., Mikami H. and Tsubone H., The difference in citric acid-induced cough in congenitally bronchial-hypersensitive (BHS) and bronchial-hyposensitive (BHR) guinea pigs, Experimental Animals. 2001, 50(5): 371-378.


Researcher : Ng IOL
Project Title:Detection of genetic alterations on chromosome 8 in liver cancer by high-throughput fluorescent in-situ hybridization on tissue microarrays and by deletion mapping
Investigator(s):Dr. Ng I.O.L., Dr. Guan X.Y.
Department:Pathology
Source(s) of Funding:Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:September 2000
Abstract:
Chromosome arm 8p has been identified as having high rates of genetic loss in many human cancers and such genetic lossess may contribute to cancer formation. The present study aims to detect genetic alterations on chromosome 8p and its association with liver cancer formation.


Project Title:Genetic progression and divergence in hepatocellular carcinoma
Investigator(s):Dr. Ng I.O.L.
Department:Pathology
Source(s) of Funding:Block Grant Earmarked for Research
Start Date:November 2000
Abstract:
To identify the genetic abnormalities at different stages of hepatocarcinogenesis (pre-neoplastic lesions, primary HCC and metastatic HCC); to identify genetic events governing tumour progression; to delineate the clinical and prognostic significance of the genetic changes in HCC with respect to tumour progression and metastasis.


Project Title:Identification and characterization of DLC-2, a candidate tumour suppressor gene on 13q frequently deleted in liver cancer
Investigator(s):Dr. Ng I.O.L., Dr. Jin D.Y.
Department:Pathology
Source(s) of Funding:Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:September 2001
Abstract:
To clone the full-length cDNA and genomic sequences of human DLC-2; to determine the accurate chromosomal localizatioin of DLC-2; to analyze the expression pattern of DLC-2 mRNA and protein in tissues and cells; to define the genotypic and phenotypic alterations of DLC-2 in HCC and hepatoma cell lines; to test the RhoGAP and tumour supressor activities of DLC-2; to characterize the signaling pathways as related to DLC-2 and cell transformation; to assess the clinical and pathological significance of DLC-2 in human HCC.


List of Research Outputs

Chan K.L., Lee M.F., Guan X.Y., Fan S.T. and Ng I.O.L., High-density allelotyping of chromosome 8p in hepatocellular carcinoma and clinicopathologic correlation, Cancer. 2002, 94(12): 3179-3185.
Chan K.L., Fan S.T., Saing H., Wei W.I., Lo C.M., Tso W.K., Yuen K.Y., Ng I.O.L., Tam P.K.H. and Wong J., Paediatric liver transplantation for biliary atresia after failed portoenterostomy, 23rd International Congress of Pediatrics, Beijing, China, 9-14 September, 2001.
Lee K.W., Lau T.C.M. and Ng I.O.L., Doxorubicin-induced apoptosis and chemosensitivity in hepatoma cell lines, Cancer Chemotherapy and Pharmacology. 2002, 49: 78-86.
Lee T.K.W., Han J.S., Fan S.T., Liang Z.D., Tian P.K., Gu J.R. and Ng I.O.L., Gene delivery using a receptor-mediated gene transfer system targeted to hepatocellular carcinoma cells, International Journal of Cancer. 2001, 93: 393-400.
Liu C.L., Fan S.T., Lo C.M., Ng I.O.L. and Wong J., Hepatic resection for combined hepatocellular cholangiocarcinoma, 5th World Congress of International Hepato-Pancreato-Biliary Association, Tokyo, 25-29 April, 2002.
Liu C.L., Fan S.T., Lo C.M., Ng I.O.L. and Wong J., Hepatic resection for mixed hepatocholangicocarcinoma (Abstract), Journal of Hepato-Biliary-Pancreatic Surgery. 2002, 9 (Suppl 1): 154.
Lo C.M., Fan S.T., Liu C.L., Yong B.H., Lai C.L., Lau G., Wei W.I., Tam P.K.H., Tsoi N.S., Ng I.O.L., Young K., Chan J.K.F., Tso W.K., Yuen K.Y. and Wong J., Ten-year experience with liver transplantation at Queen Mary Hospital, Hong Kong Medical Journal. 2002, 8: 240-244.
Ng I.O.L., Poon R.T.P. and Shek T.W., Histological activity in the noncancerous liver in patients with hepatectomy for hepatocellular carcinoma - clinicopathological correlation and survival analysis, Hepatology. Part 2, Suppl. S, 2001, 34 (4): 26.
Ng I.O.L., Poon R.T.P., Lee M.F., Fan S.T., Ng M.M.T. and Tso W.K., Microvessel density, vascular endothelial growth factor and its receptors Flt-1 and Flk-1/KDR in hepatocellular carcinoma, American Journal of Clinical Pathology. 2001, 116: 838-845.
Poon R.T.P., Ng I.O.L., Lau C., Yu W.C., Fan S.T. and Wong J., Correlation of serum basic fibroblast growth factor levels with clinicopathologic features and postoperative recurrence in hepatocellular carcinoma, American Journal of Surgery. 2001, 182(3): 298-304.
Poon R.T.P., Fan S.T., Lo C.M., Liu C.L., Ng I.O.L. and Wong J., Long-term prognosis after resection of hepatocellular carcinoma associated with hepatitis B-related cirrhosis (Classic paper and current comments: highlights of gastrointestinal cancer research), Journal of Clinical Oncology. 2002, 6: 780-788.
Qin L., Lee K.W. and Ng I.O.L., Gene expression profiling by cDNA array in human hepatoma cell line in response to cisplatin treatment, Life Sciences. 2002, 70(14): 1677-1690.
Qin L.F. and Ng I.O.L., Expression of p27KIP1 and p21WAF1/CIP1 in primary hepatocellular carcinoma: clinicopathologic correlation and survival analysis, Human Pathology. 2001, 32(8): 778-784.
Qin L.F. and Ng I.O.L., Induction of apoptosis by cisplatin and its effect on cell cycle-related proteins and cell cycle changes in hepatoma cells, Cancer Letters. 2002, 175(1): 27-38.
Saing H., Fan S.T., Lo C.M., Wei W.I., Chan K.L., Tam P.K.H., Tsoi N.S., Yuen K.Y., Ng I.O.L., Tsoi W.K. and Wong J., Paediatric liver transplantation: experience at Queen Mary Hospital, Hong Kong (1993-2001) (Abstract), 3rd Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 23-24 February, 2002.
Wong J.C.M., Fan S.T. and Ng I.O.L., b-Catenin mutation and overexpression in hepatocelluar carcinoma - clinicopathological and prognostic significance, Cancer. 2001, 92: 136-145.
Yuen M.F., Chan D.T.M., Hui C.K., Chan O.O., Ng I.O.L. and Lai C.L., Acute pancreatitis complicating acute exacerbation of chronic hepatitis B infection carries a poor prognosis, Journal of Viral Hepatitis. 2001, 8: 459-464.


Researcher : Ng SW
List of Research Outputs

Ng S.W., Population Genetics Study on the Variable Number of Tandem Repeats (VNTR) Loci of a Han Chinese Population in Hong Kong and Its Application in Human Identity (MPhil thesis). 2001.


Researcher : Nicholls JM
Project Title:A comparison of molecular changes in nasopharyngeal carciomas from Hong Kong and Northern Africa
Investigator(s):Dr. Nicholls J.M., Dr. Ooka T.
Department:Pathology
Source(s) of Funding:France/Hong Kong Joint Research Scheme
Start Date:January 2000
Completion Date:January 2002
Abstract:
To compare nasopharyngeal carcinoma biopsies from the two regions and anlyze them for changes in the cell cycle markers p53, p16 and p21.


Project Title:Detection of the deleted form of Epstein-Barr Virus (EBV) latent membrane portein 1 (LMP1) in formalin fixed biopsy samples
Investigator(s):Dr. Nicholls J.M., Dr. Graesser F.A.
Department:Pathology
Source(s) of Funding:Germany/Hong Kong Joint Research Scheme
Start Date:January 2002
Abstract:
To produce a monoclonal antibody that is able to distinguish between the wild-type LMP1 and the deleted (CAO) form; to test suitable antibodies on cell lines and tissue samples to determine if this antibody can distinguish between the wild-type and deleted forms on archival tissue; to analyze by PCR the C-terminal latent membrane protein 1 (LMP1) sequence in HK Chinese nasopharyngeal carcinomas and determine if they contain a 30 bp deletion or mutations that are different from the prototype B95-8 strain; to compare the reaction of the antibodies with the sequence in the NPC samples analyzed by PCR to identify the epitope recognized by the antibody.


List of Research Outputs

Chan L.C., Nicholls J.M. and Chan Y.S., Improving the quality of cases for problem-based learning (PBL): experience and feedback from Year 1 medical students, University of Hong Kong, Journal of Medical Education. 2002, 6(1): 95-99.
Chim J.C.S., Wong W.M., Nicholls J.M., Chung L.P. and Liang R.H.S., Hemorrhagic Gastric plasmacytoma as the Primary Presentation in Multiple myeloma., Journal of Clinical Oncology. 2002, 20: 344-347.
Fan H., Schichman S.A., Swinnen L.J., Nicholls J.M., Eagan P.A., Luther M. and Gulley M.L., Analytic validation of a competitive polymerase chain reaction assay for measuring Epstein-Barr viral load, Diagnostic Molecular Pathology. 2001, 10(4): 255-264.
Nicholls J.M., Kremmer E., Meseda C.A., Mackett M., Hahn P., Gulley M.L., Brink A., Swinnen L.J., Greenspan J., De Souza Y., Grasser F., Sham J.S.T., Ng M.H. and Arrand J.R., Comparative analysis of the expression of the Epstein-Barr virus (EBV) anti-apoptotic gene BHRF1 in nasopharyngeal carcinoma and EBV-related lymphoid diseases, Journal of Medical Virology. 2001, 65(1): 105-113.
Wei W.I., Ho W.K., Cheng C.K., Wu X., Li G., Nicholls J.M., Yuen P.W. and Sham J.S.T., Management of extensive cervical nodal metastasis in nasopharyngeal carcinoma after radiotherapy: a clinicopathological study, Archives of Otolaryngology - Head and Neck Surgery. 2001, 127(12): 1457-1462.


Researcher : Poon AYA
List of Research Outputs

Khoo U.S., Chan Y.K., Cheung A.N.Y., Xue W., Shen D.H., Fung K.Y., Ngan H.Y.S., Choy K.W., Pang C.P., Poon C.S.P., Poon A.Y.A. and Ozcelik H., Recurrent BRCA1 and BRCA2 germline mutations in ovarian cancer: a founder mutation of BRCA1 identified in the Chinese population, Human Mutation. 2002, 19(3): 307-308.


Researcher : Qin L
List of Research Outputs

Qin L., Lee K.W. and Ng I.O.L., Gene expression profiling by cDNA array in human hepatoma cell line in response to cisplatin treatment, Life Sciences. 2002, 70(14): 1677-1690.
Qin L., Significance of Cell Cycle Regulators in Human Hepatocellular Carcinoma and Gene Expression Induced by Cisplatin in Hepatoma Cell Lines (PhD thesis). 2001.


Researcher : Shek TWH
List of Research Outputs

Au W.Y., Lie A.K.W., Liang R.H.S., Liu C.L., Shek T.W.H. and Lau G., Aggressive hepatocellular carcinoma complicating pregnancy after autologous bone marrow transplantation for non-Hodgkin's lymphoma., Bone Marrow Transplantation. 2002, 29: 177-179.
Au W.Y., Ma E.S.K., Chan L.C., So C.K.C., Fung L.F. and Shek T.W.H., Chromosome 11q deletion in myeloid malignancies, Leukemia and Lymphoma. 2002, 16: 953-955.
Au W.Y., Chan H.H.L., Wong W.M., Shek T.W.H. and Yeung C.K., Cutaneous CD 30-ve T cell lymphoma with concurrent solid tumor, British Journal of Dermatology. 2002, 146: 1091-1095.
Au W.Y., Chan G.C.F., Chim J.C.S., Shek T.W.H., Ooi C.G.C., Ho W.K. and Kwong Y.L., External auditory canal tumor: a rare chloroma in acute promyelocytic leukemia with a complete response to arsenic trioxide, Journal of Clinical Oncology. 2002, 19: 3993-3995.
Au W.Y., Lie A.K.W., Shek T.W.H., Chan H.H.L. and Yeung C.K., Generalized vitiligo after lymphocyte infusion for relapsed leukemia, British Journal of Dermatology. 2001, 145: 1015-1017.
Au W.Y., Lie A.K.W., Lee C.K., Ma E.S.K., Wan T.S.K., Shek T.W.H., Liang R.H.S. and Kwong Y.L., Late onset post-transplantation lymphoproliferative disease of recipient origin following cytogenetic relapse and occult autologous haematopoietic regeneration after allogeneic bone marrow transplantation for acute myeloid leukaemia, Bone Marrow Transplantation. 2001, 28(4): 417-419.
Au W.Y., Ooi C.G.C., Shek T.W.H., Liang R.H.S. and Li K.H., Oncology emergencies: stridor in a patient with myeloma, Journal of Clinical Oncology. 2002, 20: 866-867.
Au W.Y., Lie A.K.W., Kwong Y.L., Shek T.W.H., Hawkins B.R., Lai K.N., Tang S.C.W., Lo C.M., Fan S.T., Liu C.L., Chan G.C.F., Chau M.C., Chiu S.W. and Liang R.H.S., Post-transplantation lymphoproliferative disease in Chinese: the Queen Mary Hospital experience in Hong Kong, Leukemia and Lymphoma. 2002, 43: 1405-1409.
Au W.Y., Shek T.W.H., Chan C.F., Chim J.C.S., Kwong Y.L., Ooi C.G.C. and Ho W.K., Unusual sites of involvement by hematologic malignancies: case 3. external auditory canal tumor: a rare chloroma in acute promyelocytic leukemia with a complete response to arsenic trioxide, Journal of Clinical Oncology. 2001, 19: 3993-3995.
Chan K.L., Chan G.C.F., Shek T.W.H., Li I., Ha S.Y. and Tam P.K.H., Perinatal tumours: diagnosis & results of treatment, 23rd International Congress of Pediatrics, Chinese Medical Association, Beijing, PR China, 9-14 September 2001. 111.
Chim J.C.S., Shek T.W.H., Chung L.P. and Ho J.C.Y., Gut perforation in MALToma of colon, Haematologica. 2002, 87(4): EIM15.
Chim J.C.S., Au W.Y., Liang R.H.S., Kwong Y.L., Shek T.W.H., Ma E.S.K., Ho J.C.C. and Tung H.M., Primary CD56 positive lymphomas of the fastrointestinal tract, Cancer. 2001, 91: 523-533.
Khong P.L., Chan G.C.F., Shek T.W.H., Tam P.K.H. and Chan F.L., Imaging of peripheral PNET: common and uncommon locations, Clinical Radiology. 2002, 57: 272-277.
Lam K.Y., Lo C.Y., Shek T.W.H., Ma E.S.K., Au W.Y. and Chan G.C.F., Primitive small round cell tumour of the adrenal gland presenting with fever of unknown origin and t(12;22) (q13;q12) cytogenetic finding, Journal of Clinical Pathology. 2002, 54: 966-970.
Lam Y.H., Tang M.H.Y. and Shek T.W.H., Thermocoagulation of fetal sacrococcygeal teratoma, Prenatal Diagnosis. 2002, 22: 99-101.
Shek T.W.H., Chan G.C.F., Khong P.L., Chung L.P. and Cheung A.N.Y., Ewing Sarcoma of the Small Intestine, Journal of Pediatric Hematology/Oncology. 2001, 23(8): 530-532.


Researcher : Shen L
List of Research Outputs

Shen L., Liang A.C.T., Au W.Y., Liang R.H.S. and Srivastava G., Somatic mutation of Fas gene is a common event in nasal NK/T cell lymphomas. "Lymphoma: the Next Question"., MD Anderson Cancer Center Houston, Texas, USA.. 2001.


Researcher : So CKC
List of Research Outputs

Au W.Y., Ma E.S.K., Chan L.C., So C.K.C., Fung L.F. and Shek T.W.H., Chromosome 11q deletion in myeloid malignancies, Leukemia and Lymphoma. 2002, 16: 953-955.
Ma E.S.K., Wan T.S.K., Au W.Y., Fung L.F., So C.K.C. and Chan L.C., Chromosome 11q deletion in myeloid malignancies, Leukemia. 2001, 16: 953-955.


Researcher : Srivastava G
Project Title:Mechanisms of immune evasion by the tumor cells of nasal T/NK-cell lymphoma
Investigator(s):Prof. Srivastava G., Dr. Chan A.C.L., Prof. Liang R.H.S.
Department:Pathology
Source(s) of Funding:Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:September 1998
Abstract:
1. To determine whether NL escape the immune recognition by down regulating the expression of MHC-I, MHC-II or transporter protein associated with antigen presentation-1 (TAP-1). Many viruses have evolved strategies to interfere with the process of MHC/viral peptide presentation to CTLs(called "stealth strategy"). 2. To determine whether the activated CTLs in the vicinity of NL tumor cells are inhibited by the certain immunoregulatory cytokines produced locally by either the tumor cell themselves or by the reactive influence of cytokines secreted locally, the NL tumor cells are able to proliferate by either autocrine or paracrine production of cytokines. 3. To determine whether the membrane bound Fas-L is constitutively expressed on the tumor cells of NL, and whether Fas expression is down regulated in these tumors since the Fas-L/Fas is one of the major effector systems of CTLs. The levels of Fas-L will also be determined in the sera of the patients with NL. When Fas-L expressed on the surface of tumor cells is cleaved, the soluble form of sFas-L may be released into the circulation and may cause the multi-organ failure often seen in NL patients.


Project Title:Identification and characterization of heterologous promoters which deregulate the expression of BCL-6 oncogene in gastric high-grade lymphoma of MALT-type
Investigator(s):Prof. Srivastava G., Prof. Liang R.H.S.
Department:Pathology
Source(s) of Funding:Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:September 1999
Abstract:
To identify and characterize, by employing 5' RACE technique, the heterologous promoters fused to the BCL-6 gene which deregulate the expression of BCL-6 oncogene in gastric high-grade lymphoma of MALT-type in a larger series of cases with rearranged BCL-6 genes; to study the pattern of expression of the BCL-6 partner genes by Northern blot hybridization analysis, at various stages of B-lineage differentiation and in B-cell lymphoma.


Project Title:DNA hypermethylation and mutational study of tumor suppressor gene candidates on the locus 3p21.3 in esophageal cancer
Investigator(s):Prof. Srivastava G.
Department:Pathology
Source(s) of Funding:Block Grant Earmarked for Research
Start Date:May 2002
Abstract:
To study the epigenetic and genetic alterations of the tumor suppressor gene candidates on the locus 3p21.3 since loss of heterozygosity (LOH) at the 3p21 locus is very common in ESCC.


List of Research Outputs

Fung K.L., Au W.Y., Liang R.H.S., Srivastava G. and Kwong Y.L., Aberrant methylation of gene promoters in lymphoma., 8th Hong Kong International Cancer Congress.. 2001.
Hu Y., Lam K.Y., Law S.Y.K., Wan T.S.K., Ma E.S.K., Kwong Y.L., Chan L.C., Wong J. and Srivastava G., Establishment, characterization, karyotyping, and comparative genomic hybridization analysis of HKESC-2 and HKESC-3: two newly established human esophageal squamous cell carcinoma cell lines, Cancer Genetics and Cytogenetics. 2002, 135: 120-127.
Hu Y., Lam A.K.Y., Law S., Wong J. and Srivastava G., Identification of differentially expressed genes in esophageal squamous cell carcinoma (ESCC) by cDNA expression array: overexpression of Fra-1, Neogenin, Id-1, and CDC25B genes in ESCC, Clinical Cancer Research. 2001, 7: 2213-2221.
Hu Y.C., Lam A.K.Y., Law S., Wong J. and Srivastava G., Profiling of differentially expressed cancer-related genes in esophageal squamous cell carcinoma (ESCC) using human cancer cDNA arrays: overexpression of oncogene MET correlates with tumor differentiation in ESCC, Clinical Cancer Research. 2001, 7: 3519-3525.
Shen L., Liang A.C.T., Au W.Y., Liang R.H.S. and Srivastava G., Somatic mutation of Fas gene is a common event in nasal NK/T cell lymphomas. "Lymphoma: the Next Question"., MD Anderson Cancer Center Houston, Texas, USA.. 2001.


Researcher : Tam SCF
List of Research Outputs

Cheung B.M.Y., Lo L.F., Lam T.H., Lam K.S.L., Lau C.P., Tam S.C.F., Cheng C.H. and Wat N.M.S., Changes in blood pressure after 6 years in Hong Kong cardiovascular risk factor prevalence survey cohort, Hong Kong Practitioner. 2001, 24:2(Supple): 27.
Cheung B.M.Y., Lo L.F., Lam T.H., Lam K.S.L., Lau C.P., Tam S.C.F., Wat N.M.S., Man Y.B. and Cheng C.H., Follow up of the Hong Kong cardiovascular risk factor prevalence survey cohort, J HK Coll Cardiol. 2002, 10 (Supple): 129.
Cheung B.M.Y., Law C.Y., Tam S.C.F., Kumana C.R. and Lau C.P., Plasma renin activity and aldosterone level in patients with essential hypertension, American Journal of Hypertension. 2002, 15(4): 210A.
Cheung B.M.Y., Law C.Y., Tam S.C.F., Kumana C.R. and Lau C.P., Plasma renin and aldosterone in patients with essential hypertension, 7th Scientific Meeting of the Hong Kong Pharmacology Society in Association with the Zhejiang Pharmacological Society, Hong Kong 2001.
Cheung B.M.Y., Law C.Y., Tam S.C.F., Kumana C.R. and Lau C.P., Plasma renin and aldosterone in patients with essential hypertension, Hong Kong Practitioner. 2001, 24:2(Supple): 26.
Cheung B.M.Y., Lo L.F., Lam T.H., Lam K.S.L., Lau C.P., Tam S.C.F., Wat N.M.S., Man Y.B. and Cheng C.H., Six year follow up of the Hong Kong cardiovascular risk factor prevalence survey cohort, Cardiovascular Drugs Therapeutics. 2002, 16(Supple 1): 26-27.
Chow W.S., Tan K.C.B., Tam S.C.F., Ai V.H.G., Lam C.H.L. and Lam K.S.L., Inflammation and endothelial dysfunction in patients with type 2 diabetes mellitus, 2nd International Huaxia Congress of Endocrinology. Hong Kong December, 2001. HK.
Kung A.W.C., Chau M.T., Lao T.T., Tam S.C.F. and Low L.C.K., The effect of pregnancy on thyroid nodule formation, Journal of Clinical Endocrinology & Metabolism. 2002, 87: 1010-1014.
Tan K.C.B., Chow W.S., Tam S.C.F., Ai V.H.G., Lam C.H.L. and Lam K.S.L., Atorvastatin lowers C-reactive protein and improves endothelial dysfunction in type 2 diabetes mellitus, 2nd International Huaxia Congress of Endocrinology. Hong Kong December, 2001. H.
Tan K.C.B., Chow W.S., Tam S.C.F., Ai V.H.G., Lam C.H.L. and Lam K.S.L., Atorvastatin lowers C-reactive protein and improves endothelium-dependent vasodilation in type 2 diabetes mellitus, Journal of Clinical Endocrinology and Metabolism. 2002, 87: 563-568.
Tan K.C.B., Chow W.S., Wong Y., Shiu S.W.M. and Tam S.C.F., Effects of Angiotensin II Receptor Antagonist on Plasma C-reactive Protein and Urinary Albumin Excretion in Type 2 Diabetic Patients with Microalbuminuria, American Diabetes Association 62nd Annual Meeting and Scientific Sessions. San Francisco, June 2002. USA.


Researcher : Tang CO
List of Research Outputs

Tang C.O., Cytogenetic and Molecular Study of Oesophageal Squamous Cell Carcinoma (PhD thesis). 2001.


Researcher : Tin PC
List of Research Outputs

Zheng B., Chan K.W., Im S.W.K., Chua D.T.T., Sham J.S.T., Tin P.C., He Z.M. and Ng M.H., Anti-tumor effects of human peripheral gamma-delta-T cells in a mouse tumor model, International Union Against Cancer. 2001, 92: 421-425.


Researcher : Trendell-Smith NJ
List of Research Outputs

Ooi C.G.C., Khong P.L., Lam W.K., Trendell-Smith N.J. and Tsang K.W.T., Pulmonary iron overload in thalassemia major presenting as small airway disease, Acta Haematologica. 2002, 108: 43-46.


Researcher : Tsui WY
List of Research Outputs

Tsui W.Y., Identification and characterisation of genes over-expressed in gastric adenocarcinomas, MPhil Thesis. 2002.


Researcher : Wan TSK
List of Research Outputs

Au W.Y., Yuen M.F., Lai K.C., Wan T.S.K. and Ma E.S.K., Clonal marrow abnormalities after azathioprine and sulphasalazine exposure in Crohn's disease: a cautionary tale, Leukemia and Lymphoma. 2002, 43: 1679-1681.
Au W.Y., Lie A.K.W., Lee C.K., Ma E.S.K., Wan T.S.K., Shek T.W.H., Liang R.H.S. and Kwong Y.L., Late onset post-transplantation lymphoproliferative disease of recipient origin following cytogenetic relapse and occult autologous haematopoietic regeneration after allogeneic bone marrow transplantation for acute myeloid leukaemia, Bone Marrow Transplantation. 2001, 28(4): 417-419.
Au W.Y., Lie A.K.W., Ma E.S.K., Wan T.S.K., Liang R.H.S., Leung A.Y.H. and Kwong Y.L., Philadelphia (Ph) chromosome-positive chronic myeloid leukaemia relapsing as Ph-negative leukaemia after allogeneic bone marrow transplantation, British Journal of Haematology. 2001, 114(2): 365-368.
Au W.Y., Ma E.S.K., Wan T.S.K., Man C.W.Y., Kwong Y.L. and Jim M.H., Pulmonary stenosis, demyelination and myelodysplasia with monosomy 7, Leukemia and Lymphoma. 2002, 43: 1509-1511.
Hu Y., Lam K.Y., Law S.Y.K., Wan T.S.K., Ma E.S.K., Kwong Y.L., Chan L.C., Wong J. and Srivastava G., Establishment, characterization, karyotyping, and comparative genomic hybridization analysis of HKESC-2 and HKESC-3: two newly established human esophageal squamous cell carcinoma cell lines, Cancer Genetics and Cytogenetics. 2002, 135: 120-127.
Lie A.K.W., Au W.Y., Ma E.S.K., Wan T.S.K., Liang R.H.S. and Kwong Y.L., Tynsine kinase inhibitor ST1571 in teaching Philadelphia chromosome positive leukemic relapsing from myeloablastive allogeneic., 43rd Annual Meeting of American Society of Hematology, Orlando, USA.. 2001.
Ma E.S.K., Wan T.S.K., Au W.Y., Fung L.F., So C.K.C. and Chan L.C., Chromosome 11q deletion in myeloid malignancies, Leukemia. 2001, 16: 953-955.
Wan T.S.K., Ma E.S.K., Ho M.Y., Chan L.C., Yip S.F., Wong L.G. and Yeung Y.M., Cytogenetic biclonality in polycythemia vera: unusual and unrelated clones, Cancer Genetics and Cytogenetics. 2001, 131(1): 86-89.
Wan T.S.K., Yip S.F., Yeung Y.M., Chan L.C. and Ma E.S.K., Fatal diffuse alveolar damage complicating acute myeloid leukemia with abnormal eosinophils and trisomy X, Annals of Hematology. 2002, 81: 167-169.


Researcher : Wong MP
Project Title:A study on the pathogenetic role of tumour suppressor genes in non-small cell lung cancer in Hong Kong and Shanghai Chinese female
Investigator(s):Dr. Wong M.P., Dr. Chiu C.S.W., Dr. Chung L.P., Dr. Fu K.H., Prof. Lam W.K., Dr. Yew W.W.
Department:Pathology
Source(s) of Funding:Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:October 1998
Abstract:
To investigate the pathogenetic role of tumour suppressor genes in non-small cell lung carcinoma (NSCLC) in Hong Kong and Shanghai Chinese females.


Project Title:A study of the angiogenesis pathway in primary carcinoma of the lung
Investigator(s):Dr. Wong M.P., Dr. Chung L.P.
Department:Pathology
Source(s) of Funding:Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:November 1999
Abstract:
To evaluate the profile of expression of ARF involved in the regulation of angiogenic pathways in lung carcinomas, including up-regulated or down-regulated molecules compared to normal lung; to identify the source of expression of the ARF with altered expression levels; to determine whether there is any association between the pattern of expression of the ARF and the patients' profile, histological type, growth pattern, microvessel density, stage and prognostic indices of the tumours.


Project Title:Genetic and epigenetic changes of RASSF1 in lymphoepithelioma-like carcinoma of lung
Investigator(s):Dr. Wong M.P., Dr. Chung L.P.
Department:Pathology
Source(s) of Funding:Block Grant Earmarked for Research
Start Date:November 2001
Abstract:
To study the genetic and epigenetic changes of the tumour suppressor gene, RASSF1, in primary lymphoepithelioma-like carcinomas (LELC) of the lung.


Project Title:Analysis of genetic changes in non-small cell lung cancers from non-smokers in Hong Kong
Investigator(s):Dr. Wong M.P., Dr. Chiu S.W., Dr. Chung L.P., Prof. Lam W.K.
Department:Pathology
Source(s) of Funding:Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:January 2002
Abstract:
To identify loci of significant DNA gain, implicating the presence of potential oncogences, or loss, implicating the presence of potential tumour suppressor genes (TSG) in NSCLC from non-smokers; to identify genes or DNA sequences that show up -or down- regulated expression levels in NSCLC of non-smokers compared to normal lung; to identify and analyse candidate oncogenes or TSG for activating mutations or inactivating genetic or epigenetic alterations.


List of Research Outputs

Ho J.C.M., Lam C.L., Ip S., Wong M.P., Lam W.K. and Tsang K.W.T., Exhaled nitric oxide predicts lung function but not quality of life in subjects with non-small cell lung cancer, Medical Research Conference, University Department of Medicine, Hong Kong, 2002. The Hong Kong Practitioner. 2002, 24 (2): 57 (C-RC-7).
Lam B., Lam W.K., Lam C.L., Ooi C.G.C., Ho J.C.M., Wong M.P. and Tsang K.W.T., Adenocarcinoma of the lung in Chinese patients: a revisit and some perspectives from the literature, Postgraduate Medical Journal. 2001, 77(913): 708-712.
Lam C.L., Lam W.K., Wong M.P., Chung L.P., Ip M.S.M., Tsang K.W.T., Chau W.S., Suen W.S. and Chiu S.W., Establishment and application of primary lung cancer cell lines (The HKULC Series) with local Chinese characteristics in Hong Kong, Joint Annual Scientific Meeting, Hong Kong Thoracic Society, Chinese Thoracic Society and American College of Chest Physicians, Hong Kong. 2002. Abstract pp.26.
Lam C.L., Lam W.K., Wong M.P., Chung L.P., Chiu S.W. and Chau W.S., Establishment of HKU lung cancer lines in Hong Kong - an ongoing conjoint effort and progress report, Medical Research Conference, University Department of Medicine, Hong Kong, 2002. The Hong Kong Practitioner. 2002, 24 (2): 55 (C-RC-2).
Lam C.L., Lam W.K., Wong M.P., Chung L.P., Chiu S.W., Chau W.S. and Ho K.K., Promotor hypermethylation of the CpG Islands of human Ras Association Domain Family 1A gene (RASSF1A) in adenocarcinoma of lung in Hong Kong Chinese - a comparison between smokers and non-smokers, Medical Research Conference, University Department of Medicine, Hong Kong, 2002. The Hong Kong Practitioner. 2002, 24 (2): 54 (C-RC-1).
Lam C.L., Lam W.K., Wong Y., Ooi C.G.C., Wong M.P., Ho J.C.M., Lam B. and Tsang K.W.T., Pulmonary cryptococcosis : a case report and review of the Asian-Pacific experience, Respirology. 2001, 6: 351-355.
Wong M.P., Chung P.L., Lam W.K., Chiu S.W. and Fu K.H., Allelic imbalance in chromosomes 3, 9 and 17 in lung cancers of non-smokers in Hong Kong, Proceedings of the American Association for Cancer Research. 2001, 42: 633(#3404).
Wong M.P., Chung L.P., Lam W.K., Chiu S.W. and Fu K.H., Allelic imbalance in lung cancers of non-smokers in Hong Kong, Oncogenomics Conference of the American Association for Cancer Research, Tucson, USA. 2001, Proceedings 2001: 48.


Researcher : Xue W
List of Research Outputs

Khoo U.S., Chan Y.K., Cheung A.N.Y., Xue W., Shen D.H., Fung K.Y., Ngan H.Y.S., Choy K.W., Pang C.P., Poon C.S.P., Poon A.Y.A. and Ozcelik H., Recurrent BRCA1 and BRCA2 germline mutations in ovarian cancer: a founder mutation of BRCA1 identified in the Chinese population, Human Mutation. 2002, 19(3): 307-308.
Liu S., Tsang B.K., Cheung A.N.Y., Xue W., Cheng D.K.L., Ng T.Y., Wong R.L.C. and Ngan H.Y.S., Anti-apoptotic proteins, apoptotic and proliferative parameters and their prognostic significance in cervical carcinoma, European Journal of Cancer. 2001, 37: 1104-1110.
Xue W., Guan X.Y., Ngan H.Y.S., Shen D.H., Khoo U.S. and Cheung A.N.Y., Malignant placental site trophoblastic tumor: a cytogenetic study using comparative genomic hybridization and chromosome in situ hybridization, Cancer. 2002, 94(8): 2288-2294.
Wang X., Khoo U.S., Xue W. and Cheung A.N.Y., Cervical and peritoneal fluid cytology of uterine sarcomas, Acta Cytologica. 2002, 46(3): 465-469.


Researcher : Yam JWP
List of Research Outputs

Wong S.C.C., Lo S.F.E., Lee K.C., Yam J.W.P., Chan J.K.C. and Hsiao W.W.L., Expression of frizzled-related protein and Wnt-signalling molecules in invasive human breast tumours, Journal of Pathology. 2002, 196: 145-153.


Researcher : Yuen ST
List of Research Outputs

Davies H., Bignell G.R., Cox C., Stephens P., Edkins S., Clegg S., Teague J., Woffendin H., Garnett M.J., Bottomley W., Davis N., Dicks E., Ewing R., Floyd Y., Gray K., Hall S., Hawes R., Hughes J., Kosmidou V., Menzies A., Mould C., Parker A., Stevens C., Watt S., Hooper S., Wilson R., Jayatilake H., Gusterson B.A., Cooper C., Shipley J., Hargrave D., Pritchard-Jones K., Maitland N., Chenevix-Trench G., Riggins G.J., Bigner D.D., Palmieri G., Cossu A., Flanagan A., Nicholson A., Ho J.W.C., Leung S.Y., Yuen S.T., Weber B.L., Seigler H.F., Darrow T.L., Paterson H., Marais R., Marshall C.J., Wooster R., Stratton M.R. and Futreal P.A., Mutations of the BRAF gene in human cancer, Nature. 2002, 417: 949-954.
Lau G., Suri D., Liang R.H.S., Rigoponlon E.I., Thomas M.G., Mullerova , Yuen S.T., Williams R. and Naoumov N.V., Adoptive transfer of immunity to hepatitis B virus nucleocapsid protein terminates chronic HBV infection., Gastroenterology. 2002, 122: 614-624.
Lau G., Suri D., Liang R.H.S., Rigopoulou E.I., Thomas M.G., Mullerova I., Nanji A.A., Yuen S.T., Williams R. and Naoumov N.V., Resolution of chronic hepatitis B and anti-HBs seroconversion in humans by adoptive transfer of immunity to hepatitis B core antigen, Gastroenterology. 2002, 122(3): 614-624.
Lau G., Nanji A.A., Hou J., Fong D.Y.T., Au W.S., Yuen S.T. and Lin M.C., Thymosin-a1 and famciclovir combination therapy activates T-cell response in patients with chronic hepatitis B virus infection in immune-tolerant phase, Journal of Viral Hepatitis. 2002, 9: 280-287.
Nanji A.A., Lau G., Tipoe G.L., Yuen S.T., Chen Y.X., Thomas P. and Lan H.Y., Macrophage migration inhibitory factor expression in male and female ethanol-fed rats, Journal of Interferon and Cytokine Research. 2001, 21(12): 1055-1062.
Wong B.C.Y., Lam S.K., Wong W.M., Zheng T., Chen J.S., Chen B.W., Lai K.C., Yuen S.T. and Ho J.C.Y., Eradicating Helicobacter pylori infection in general population prevents gastric cancer: 1 7 year prospective randomized placebo-controlled study, Gastroenterology. 2002, 122 (4 suppl 1): A588.
Wong B.C.Y., Lam S.K., Wong W.M., Feng R.E., Zheng T., Yuen S.T., Ho J.C.Y., Leung S.Y., Chen J.S. and Lai K.C., Eradication of Helicobacter pylori infection significantly slows down the progression of precancerous lesions in high risk population: a 5-year prospective randomized study, Gastroenterology. 2002, 122 (4 suppl 1): A588.
Wong W.M., Wong B.C.Y., Tang V.S., Lai K.C., Yuen S.T., Leung S.Y. and Hu H.C., An evaluation of the PyloriTek test for the diagnosis of Helicobacter pylori infection in Chinese patients before and after eradication therapy, Journal of Gastroenterology and Hepatology. 2001, 16(9): 976-980.
Xia H.H.X., Wong B.C.Y., Huang X.R., He X.X., Wong W.M., Leung S.Y., Yuen S.T., Lan H.Y. and Lam S.K., Expression of macrophage migration inhibitory factor in Helicobacter pylori induced gastritis and peptic ulcer disease, The Hong Kong Practitioner. 2002, 24 (2 suppl): 41.


-- End of Listing --
 

For enquiry, please contact rssdata@hkusua.hku.hk
Copyright (c) 2002 The University of Hong Kong. All rights reserved.