CENTRE FOR THE STUDY OF LIVER DISEASE
| Researcher : Ho JCY |
| Project Title: | Functional characterization of Glycosyl-phosphatidylinositol (GPI) anchor attachment protein 1 (GAA1) in liver cancer |
| Investigator(s): | Ho JCY, Fan ST, Cheung ST |
| Department: | Centre for the Study of Liver Disease |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2004 |
| Completion Date: | 10/2005 |
| Abstract: |
| To determine the expression level of GAA1 in HCC; to elucidate the function of GAA1 in liver cancer. |
| List of Research Outputs |
| Researcher : Ho JWY |
| Project Title: | Study on circulating endothelial progenitor cell in hepatocellular carcinoma - potential biomarker of tumor angiogenesis and target for anti-angiogenic therapy |
| Investigator(s): | Ho JWY, Poon RTP, Fan ST |
| Department: | Centre for the Study of Liver Disease |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2004 |
| Completion Date: | 04/2006 |
| Abstract: |
| To assess the levels of circulating endothelial progenitor cells in hepatocellular carcinoma (HCC). |
| List of Research Outputs |
| Researcher : Yang Z |
| Project Title: | Evaluation of HIF-1α and VEGF expression after hypoxia and chemotherapy in hepatocellular carcinoma |
| Investigator(s): | Yang Z, Fan ST, Poon RTP |
| Department: | Centre for the Study of Liver Disease |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2004 |
| Completion Date: | 10/2005 |
| Abstract: |
| To investigate the expression pattern of HIF-1α and VEGF in serially collected tissue and plasma samples after hypoxia and chemotherapy in an orthotopic HCC model in rat. |
| Project Title: | Combination of mTOR inhibitor with chemo-cytotoxic agent for the treatment of hepatocellular carcinoma |
| Investigator(s): | Yang Z, Poon RTP |
| Department: | Surgery |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 01/2006 |
| Completion Date: | 12/2006 |
| Abstract: |
| Objective: Hepatocellular carcinoma (HCC) ranks fifth in frequency worldwide among all malignancies and causes one million deaths annually. Hepatic resection and liver transplantation are the only two approaches that may cure HCC, but the majority of patients present with an advanced stage beyond surgical treatment. Chemotherapy is widely employed to treat unresectable HCC, but the efficacy is not satisfactory due to the resistance of tumor cells to the chemo-cytotoxic agents. The mammalian target of rapamycin (mTOR) has been demonstrated to play an important role in the chemo-resistant pathways in some tumors. Therefore, we design the present study to evaluate the therapeutic potential of mTOR inhibition on enhancement of chemo-sensitivity of HCC tumor cells to chemo-cytotoxic agents. |
| List of Research Outputs |