DEPT OF MEDICINE

Researcher : Au WY



List of Research Outputs

 

Au W.Y., Lam C.C.K., Chim J.C.S., Pang A.W.K. and Kwong Y.L., Alemtuzumab induced complete remission of therapy-resistant pure red cell aplasia , Leukemia Research . 2005, 29, Issue 10: 1213-1215.

 

Au W.Y., Cheng T.S., Siu T.S. and Yuen K.Y., Cerebellar degeneration and folate deficiency due to cough misture abuse, Haematologica. 2005, 90:(ECR)28: Epub.

 

Au W.Y., Pang A.W.K., Wan T.S.K., Ma E.S.K., Cheng L.C. and Kwong Y.L., Concomitant post-transplantation lymphoproliferative disease and therapy-related myelodysplastic syndrome after lung transplantation , The Journal of Heart and Lung Transplantation . 2006, 25(2): 259-260.

 

Au W.Y., Tam S., Fong B.M. and Kwong Y.L., Elemental arsenic entered the cerebrospinal fluid during oral arsenic trioxide treatment of meningeal relapse of acute promyelocytic leukemia , Blood. 2006, 107(7): 3012-3013.

 

Au W.Y., Pang A.W.K., Chan C., Chu K.M., Shek T.W.H. and Kwong Y.L., Epstein-barr virus-related gastric adenocarcinoma: an early secondary cancer post hemopoietic stem cell transplantation, Gastroenterology. 2005, 129(6): 2058-63.

 

Au W.Y. and Kwong Y.L., Frequent varicella zoster reactivation associated with therapeutic use of arsenic trioxide: portents of an old scourge, Journal of the American Academy of Dermatology. 2005, 53(5): 890-2.

 

Au W.Y., Kwong Y.L. and Yuen K.Y., Hemophagocytosis in the peripheral blood due to tuberculosis mycobacteremia, American Journal of Medicine. 2005, 118(11): 1298-9.

 

Au W.Y., Lam C.C.K., Liu C.L. and Yuen R.M.F., Hepatitis C virus infection in adult Chinese hemophilia patients negative for the human immunodeficiency virus: treatment results with interferon and ribavirin, International Journal of Hematology. 2005, 82(3): 259-261.

 

Au W.Y., Cheung W.C., Hu H.C., Chan G.C.F., Ha S.Y., Khong P.L., Ma E.S.K. and Liang R.H.S., Hyperbilirubinaemia and cholelithiasis in Chinese patients with hemoglobin H disease., Annals of Hematology. 2005, 84(10): 671-674.

 

Au W.Y., Liu C.L., Lo C.M., Fan S.T. and Lam C.C.K., Living donor liver transplantation for hepatitis C related hepatocellular carcinoma in a haemophilia A patient (Case Report), Haemophilia. 2005, 11(4): 405-407.

 

Au W.Y., Lie A.K.W., Cheng J.W., Liang R.H.S. and Kwong Y.L., Long-term donor health and its relationship with outcome of allogeneic hematopoietic stem cell transplantation, Bone Marrow Transplantation. 2006, 37(5): 451-3.

 

Au W.Y. and Lau L.S., Massive haemolysis because of Clostridium perfringes liver abscess in a patient on peritoneal dialysis, British Journal of Haematology. 2005, 131: 2.

 

Au W.Y., Fung T.K. and Liang R.H.S., Molecular epidemiology of follicular lymphoma in Chinese: relationship with bcl-2IgH translocation and bcl-6 397G/C polymorphism, Annals of Hematology. 2005, 84(8): 506-9.

 

Au W.Y., Chan L.C., Liang R.H.S. and Kwong Y.L., Myelodysplastic syndrome and acute myeloid leukemia after treatment with fludarabine, mitoxantrone, and dexamethasone, American Journal of Hematology. 2006, 81(6): 471-3.

 

Au W.Y. and Kwong Y.L., Peripartum pulmonary embolism in a patient with concomitant hemoglobin Newcastle, hemoglobin Constant Spring, and hereditary spherocytosis, American Journal of Hematology. 2005, 80(2): 166.

 

Au W.Y., Fung T.K., Ma E.S.K., Chan C.H., Wong K.F., Chim J.C.S., Liang R.H.S. and Kwong Y.L., Serial studies of methylation of CDKN2B and CDKN2A in relapsed acute promyelocytic leukaemia treated with arsenic trioxide, British Journal of Haematology. 2005, 131: 632.

 

Au W.Y., Hung K.N., Shek T.W.H. and Ma E.S.K., Side effects related to cancer treatment: CASE 3. Primary cerebral lymphoma after radiotherapy for recurrent meningioma, Journal of Clinical Oncology. 2005, 23(33): 8535-6.

 

Au W.Y., Kumana C.R., Lam C.W., Cheng V.C.C., Shek T.W.H., Chan E.Y.T., Liu K.Y. and Kwong Y.L., Solid tumors subsequent to arsenic trioxide treatment for acute promyelocytic leukemia, Leukemia Research. 2006.

 

Au W.Y., Ma E.S.K., Choy C., Chung L.P., Fung T.K., Liang R.H.S. and Kwong Y.L., Therapy-related lymphomas in patients with autoimmune diseases after treatment with disease-modifying anti-rheumatic drugs, American Journal of Hematology. 2005, 81(1): 5-11.

 

Au W.Y., Cheng V.C.C. and Lie A.K.W., Toxoplasma Gondii Serology and Stem Cell Transplantation in Chinese, Transplantation. 2005, 37(10): 4497-4499.

 

Chen W.Y.W., Hu X., Liang A.C.T., Au W.Y., So J.C.C., Wong M.L.Y., Shen L., Tao Q., Chu K.M., Kwong Y.L., Liang R.H.S. and Srivastava G., High BCL6 expression predicts better prognosis, independent of BCL6 translocation status, translocation partner, or BCL6 deregulating mutations, in gastric lymphoma, Blood. 2006, 108(7): 2373-83.

 

Hon C., Ma E.S.K. and Au W.Y., A patient with anophthalmia, hemifacial microsomia, and hemoglobin anti-Lepore, Annals of Hematology. 2005, 84(9): 623-4.

 

Hon C., Chan R.T., Ma E.S.K., Shek T.W.H., Yau K. and Au W.Y., Lymphomatous proptosis as a novel featur of mantle cell lymphoma, Leukemia & Lymphoma. 2006, 47(1): 71-5.

 

Hon C., Au W.Y. and Cheng V.C.C., Ophthalmic zoster sine herpete presenting as oculomotor palsy after marrow transplantation for acute myeloid leukemia, Haematologica. 2005, 90(12Suppl): EIM04.

 

Hon C., Chui W.H., Cheng L.C., Shek T.W.H., Jones B.M. and Au W.Y., Thymoma associated with keratoconjunctivitis, lichen planus, hypogammaglobinemia, and absent circulating B cells, Journal of Clinical Oncology. 2006, 24(18): 2960-1.

 

Hu X., Liang A.C.T., Chen W.Y.W., Tao Q., Wong M.L.Y., Shen L., Wong K.Y., Au W.Y., Cheung W.L., Chu K.M., Kwong Y.L., Liang R.H.S. and Srivastava G., CD44 expression is regulated by translocation and promoter hypermethylation in gastric lymphoma, Proceedings of the 12th Hong Kong International Cancer Congress and 2nd Annual Meeting of Centre for Cancer Research, Hong Kong SAR, China, December 2005.

 

Hu X., Liang A.C.T., Chen W.Y.W., Tao Q., Au W.Y., Wong M.L.Y., Shen L., Wong K.Y., Wan T.S.K., Cheung W.L., Chu K.M., Chan L.C., Kwong Y.L., Liang R.H.S. and Srivastava G., CD44 expression is regulated by translocation and promoter hypermethylation in gastric lymphoma, Proceedings of 97th Annual Meeting of American Association for Cancer Research (AACR), Washington D.C., USA, April 2006 . 2006.

 

Hui C.K., Lie A.K.W., Au W.Y., Leung A.Y.H., Ma S.Y., Cheung W.W., Zhang H., Chim J.C.S., Kwong Y.L., Liang R.H.S. and Lau G., A long-term follow-up study on hepatitis B surface antigen-positive patients undergoing allogeneic hematopoietic stem cell transplantation, Blood. 2005, 106(2): 464-9.

 

Hui C.K., Cheung W., Au W.Y., Lie A.K.W., Zhang H., Yueng Y.H., Wong B.C.Y., Leung N., Kwong Y.L., Liang R.H.S. and Lau G., Hepatitis B reactivation after withdrawal of preemptive lamivudine in patients with hematological malignancy upon completion of cytotoxic chemotherapy, Liver International 2005. 2005, Oct: 182.

 

Hui C.K., Ma S.Y., Sun J., Au W.Y., Lie A.K.W., Chim J.C.S., Kwong Y.L., Liang R.H.S. and Lau G., Hepatitis B reactivation in patient with occult HBV infection after chemotherapy, J Hepatol. 2005, 42(6): 813-19.

 

Hui C.K., Cheung W.W., Zhang H., Au W.Y., Yueng Y.H., Leung A.Y.H., Leung N., Luk J.M.C., Lie A.K.W., Kwong Y.L., Liang R.H.S. and Lau G., Kinetics and risk of de novo hepatitis B infection in HBsAg negative patients undergoing cytotoxic chemotherapy, Gastroenterology. 2006, 131: 59-68.

 

Hui C.K., Cheung W.W., Zhang H., Au W.Y., Yueng Y.H., Leung A.Y.H., Leung N., Luk J.M.C., Lie A.K.W., Kwong Y.L., Liang R.H.S. and Lau G., Rituximab increases the Risk of De Novo hepatitis B infection in Hepatitis B Surface Antigen Negative Patients Undergoing Cytotoxic Chemotherapy, J Gastroenterol and Hepatol. 2006, 21(2): A73.

 

Kwong Y.L., Chow C., Kumana C.R., Srivastava G. and Au W.Y., Arsenic trioxide in mantle cell lymphoma, Blood (American Society of Hematology 2005 Annual Meeting Abstracts) . 2005, 106 (11): 283B-284B 4814 Part 2 Nov 16 2005.

 

Leung R., Chou E.E., Au W.Y., Chow C., Kwong Y.L., Lin S.Y., Ma E.S.K., Wan T.S.K. and Wong K.F., CD4+/CD56+ hematologic malignancy with rearranged MLL gene, Human Pathology . 2006, 37(2): 247-249.

 

Ooi C.G.C., Chim J.C.S., Au W.Y. and Khong P.L., Radiologic Manifestations of Primary Solitary Extramedullary and Multiple Solitary Plasmacytomas , AJR. American journal of roentgenology. 2006, 186(3): 821-7.

 

Yip B.H., Guo T., Hu X., Wong K.Y., Chen W.Y.W., Au W.Y., Chu K.M., Kwong Y.L., Liang R.H.S. and Srivastava G., Identification of two novel translocations t(14;20)(q32;q12) and t(2;14)(q23;q32) in gastric lymphoma, Proceedings of the 12th Hong Kong International Cancer Congress and 2nd Annual Meeting of Centre for Cancer Research, Hong Kong SAR, China, December 2005.

 

Yip B.H., Guo T., Hu X., Au W.Y., Wong K.Y., Wan T.S.K., Chen W.Y.W., Chu K.M., Chan L.C., Kwong Y.L., Liang R.H.S. and Srivastava G., Identification of two novel translocations t(14;20)(q32;q12) and t(2;14)(q23;q32) involving immunoglobulin heavy chain gene locus in gastric lymphoma, Proceedings of 97th Annual Meeting of American Association for Cancer Research (AACR), Washington D.C., USA, April 2006.

 

Researcher : Au WY



List of Research Outputs

 

Au W.Y., Lam C.C.K., Chim J.C.S., Pang A.W.K. and Kwong Y.L., Alemtuzumab induced complete remission of therapy-resistant pure red cell aplasia , Leukemia Research . 2005, 29, Issue 10: 1213-1215.

 

Au W.Y., Cheng T.S., Siu T.S. and Yuen K.Y., Cerebellar degeneration and folate deficiency due to cough misture abuse, Haematologica. 2005, 90:(ECR)28: Epub.

 

Au W.Y., Pang A.W.K., Wan T.S.K., Ma E.S.K., Cheng L.C. and Kwong Y.L., Concomitant post-transplantation lymphoproliferative disease and therapy-related myelodysplastic syndrome after lung transplantation , The Journal of Heart and Lung Transplantation . 2006, 25(2): 259-260.

 

Au W.Y., Tam S., Fong B.M. and Kwong Y.L., Elemental arsenic entered the cerebrospinal fluid during oral arsenic trioxide treatment of meningeal relapse of acute promyelocytic leukemia , Blood. 2006, 107(7): 3012-3013.

 

Au W.Y., Pang A.W.K., Chan C., Chu K.M., Shek T.W.H. and Kwong Y.L., Epstein-barr virus-related gastric adenocarcinoma: an early secondary cancer post hemopoietic stem cell transplantation, Gastroenterology. 2005, 129(6): 2058-63.

 

Au W.Y. and Kwong Y.L., Frequent varicella zoster reactivation associated with therapeutic use of arsenic trioxide: portents of an old scourge, Journal of the American Academy of Dermatology. 2005, 53(5): 890-2.

 

Au W.Y., Kwong Y.L. and Yuen K.Y., Hemophagocytosis in the peripheral blood due to tuberculosis mycobacteremia, American Journal of Medicine. 2005, 118(11): 1298-9.

 

Au W.Y., Lam C.C.K., Liu C.L. and Yuen R.M.F., Hepatitis C virus infection in adult Chinese hemophilia patients negative for the human immunodeficiency virus: treatment results with interferon and ribavirin, International Journal of Hematology. 2005, 82(3): 259-261.

 

Au W.Y., Cheung W.C., Hu H.C., Chan G.C.F., Ha S.Y., Khong P.L., Ma E.S.K. and Liang R.H.S., Hyperbilirubinaemia and cholelithiasis in Chinese patients with hemoglobin H disease., Annals of Hematology. 2005, 84(10): 671-674.

 

Au W.Y., Liu C.L., Lo C.M., Fan S.T. and Lam C.C.K., Living donor liver transplantation for hepatitis C related hepatocellular carcinoma in a haemophilia A patient (Case Report), Haemophilia. 2005, 11(4): 405-407.

 

Au W.Y., Lie A.K.W., Cheng J.W., Liang R.H.S. and Kwong Y.L., Long-term donor health and its relationship with outcome of allogeneic hematopoietic stem cell transplantation, Bone Marrow Transplantation. 2006, 37(5): 451-3.

 

Au W.Y. and Lau L.S., Massive haemolysis because of Clostridium perfringes liver abscess in a patient on peritoneal dialysis, British Journal of Haematology. 2005, 131: 2.

 

Au W.Y., Fung T.K. and Liang R.H.S., Molecular epidemiology of follicular lymphoma in Chinese: relationship with bcl-2IgH translocation and bcl-6 397G/C polymorphism, Annals of Hematology. 2005, 84(8): 506-9.

 

Au W.Y., Chan L.C., Liang R.H.S. and Kwong Y.L., Myelodysplastic syndrome and acute myeloid leukemia after treatment with fludarabine, mitoxantrone, and dexamethasone, American Journal of Hematology. 2006, 81(6): 471-3.

 

Au W.Y. and Kwong Y.L., Peripartum pulmonary embolism in a patient with concomitant hemoglobin Newcastle, hemoglobin Constant Spring, and hereditary spherocytosis, American Journal of Hematology. 2005, 80(2): 166.

 

Au W.Y., Fung T.K., Ma E.S.K., Chan C.H., Wong K.F., Chim J.C.S., Liang R.H.S. and Kwong Y.L., Serial studies of methylation of CDKN2B and CDKN2A in relapsed acute promyelocytic leukaemia treated with arsenic trioxide, British Journal of Haematology. 2005, 131: 632.

 

Au W.Y., Hung K.N., Shek T.W.H. and Ma E.S.K., Side effects related to cancer treatment: CASE 3. Primary cerebral lymphoma after radiotherapy for recurrent meningioma, Journal of Clinical Oncology. 2005, 23(33): 8535-6.

 

Au W.Y., Kumana C.R., Lam C.W., Cheng V.C.C., Shek T.W.H., Chan E.Y.T., Liu K.Y. and Kwong Y.L., Solid tumors subsequent to arsenic trioxide treatment for acute promyelocytic leukemia, Leukemia Research. 2006.

 

Au W.Y., Ma E.S.K., Choy C., Chung L.P., Fung T.K., Liang R.H.S. and Kwong Y.L., Therapy-related lymphomas in patients with autoimmune diseases after treatment with disease-modifying anti-rheumatic drugs, American Journal of Hematology. 2005, 81(1): 5-11.

 

Au W.Y., Cheng V.C.C. and Lie A.K.W., Toxoplasma Gondii Serology and Stem Cell Transplantation in Chinese, Transplantation. 2005, 37(10): 4497-4499.

 

Chen W.Y.W., Hu X., Liang A.C.T., Au W.Y., So J.C.C., Wong M.L.Y., Shen L., Tao Q., Chu K.M., Kwong Y.L., Liang R.H.S. and Srivastava G., High BCL6 expression predicts better prognosis, independent of BCL6 translocation status, translocation partner, or BCL6 deregulating mutations, in gastric lymphoma, Blood. 2006, 108(7): 2373-83.

 

Hon C., Ma E.S.K. and Au W.Y., A patient with anophthalmia, hemifacial microsomia, and hemoglobin anti-Lepore, Annals of Hematology. 2005, 84(9): 623-4.

 

Hon C., Chan R.T., Ma E.S.K., Shek T.W.H., Yau K. and Au W.Y., Lymphomatous proptosis as a novel featur of mantle cell lymphoma, Leukemia & Lymphoma. 2006, 47(1): 71-5.

 

Hon C., Au W.Y. and Cheng V.C.C., Ophthalmic zoster sine herpete presenting as oculomotor palsy after marrow transplantation for acute myeloid leukemia, Haematologica. 2005, 90(12Suppl): EIM04.

 

Hon C., Chui W.H., Cheng L.C., Shek T.W.H., Jones B.M. and Au W.Y., Thymoma associated with keratoconjunctivitis, lichen planus, hypogammaglobinemia, and absent circulating B cells, Journal of Clinical Oncology. 2006, 24(18): 2960-1.

 

Hu X., Liang A.C.T., Chen W.Y.W., Tao Q., Wong M.L.Y., Shen L., Wong K.Y., Au W.Y., Cheung W.L., Chu K.M., Kwong Y.L., Liang R.H.S. and Srivastava G., CD44 expression is regulated by translocation and promoter hypermethylation in gastric lymphoma, Proceedings of the 12th Hong Kong International Cancer Congress and 2nd Annual Meeting of Centre for Cancer Research, Hong Kong SAR, China, December 2005.

 

Hu X., Liang A.C.T., Chen W.Y.W., Tao Q., Au W.Y., Wong M.L.Y., Shen L., Wong K.Y., Wan T.S.K., Cheung W.L., Chu K.M., Chan L.C., Kwong Y.L., Liang R.H.S. and Srivastava G., CD44 expression is regulated by translocation and promoter hypermethylation in gastric lymphoma, Proceedings of 97th Annual Meeting of American Association for Cancer Research (AACR), Washington D.C., USA, April 2006 . 2006.

 

Hui C.K., Lie A.K.W., Au W.Y., Leung A.Y.H., Ma S.Y., Cheung W.W., Zhang H., Chim J.C.S., Kwong Y.L., Liang R.H.S. and Lau G., A long-term follow-up study on hepatitis B surface antigen-positive patients undergoing allogeneic hematopoietic stem cell transplantation, Blood. 2005, 106(2): 464-9.

 

Hui C.K., Cheung W., Au W.Y., Lie A.K.W., Zhang H., Yueng Y.H., Wong B.C.Y., Leung N., Kwong Y.L., Liang R.H.S. and Lau G., Hepatitis B reactivation after withdrawal of preemptive lamivudine in patients with hematological malignancy upon completion of cytotoxic chemotherapy, Liver International 2005. 2005, Oct: 182.

 

Hui C.K., Ma S.Y., Sun J., Au W.Y., Lie A.K.W., Chim J.C.S., Kwong Y.L., Liang R.H.S. and Lau G., Hepatitis B reactivation in patient with occult HBV infection after chemotherapy, J Hepatol. 2005, 42(6): 813-19.

 

Hui C.K., Cheung W.W., Zhang H., Au W.Y., Yueng Y.H., Leung A.Y.H., Leung N., Luk J.M.C., Lie A.K.W., Kwong Y.L., Liang R.H.S. and Lau G., Kinetics and risk of de novo hepatitis B infection in HBsAg negative patients undergoing cytotoxic chemotherapy, Gastroenterology. 2006, 131: 59-68.

 

Hui C.K., Cheung W.W., Zhang H., Au W.Y., Yueng Y.H., Leung A.Y.H., Leung N., Luk J.M.C., Lie A.K.W., Kwong Y.L., Liang R.H.S. and Lau G., Rituximab increases the Risk of De Novo hepatitis B infection in Hepatitis B Surface Antigen Negative Patients Undergoing Cytotoxic Chemotherapy, J Gastroenterol and Hepatol. 2006, 21(2): A73.

 

Kwong Y.L., Chow C., Kumana C.R., Srivastava G. and Au W.Y., Arsenic trioxide in mantle cell lymphoma, Blood (American Society of Hematology 2005 Annual Meeting Abstracts) . 2005, 106 (11): 283B-284B 4814 Part 2 Nov 16 2005.

 

Leung R., Chou E.E., Au W.Y., Chow C., Kwong Y.L., Lin S.Y., Ma E.S.K., Wan T.S.K. and Wong K.F., CD4+/CD56+ hematologic malignancy with rearranged MLL gene, Human Pathology . 2006, 37(2): 247-249.

 

Ooi C.G.C., Chim J.C.S., Au W.Y. and Khong P.L., Radiologic Manifestations of Primary Solitary Extramedullary and Multiple Solitary Plasmacytomas , AJR. American journal of roentgenology. 2006, 186(3): 821-7.

 

Yip B.H., Guo T., Hu X., Wong K.Y., Chen W.Y.W., Au W.Y., Chu K.M., Kwong Y.L., Liang R.H.S. and Srivastava G., Identification of two novel translocations t(14;20)(q32;q12) and t(2;14)(q23;q32) in gastric lymphoma, Proceedings of the 12th Hong Kong International Cancer Congress and 2nd Annual Meeting of Centre for Cancer Research, Hong Kong SAR, China, December 2005.

 

Yip B.H., Guo T., Hu X., Au W.Y., Wong K.Y., Wan T.S.K., Chen W.Y.W., Chu K.M., Chan L.C., Kwong Y.L., Liang R.H.S. and Srivastava G., Identification of two novel translocations t(14;20)(q32;q12) and t(2;14)(q23;q32) involving immunoglobulin heavy chain gene locus in gastric lymphoma, Proceedings of 97th Annual Meeting of American Association for Cancer Research (AACR), Washington D.C., USA, April 2006.

 

Researcher : Au WY



List of Research Outputs

 

Au W.Y., Lam C.C.K., Chim J.C.S., Pang A.W.K. and Kwong Y.L., Alemtuzumab induced complete remission of therapy-resistant pure red cell aplasia , Leukemia Research . 2005, 29, Issue 10: 1213-1215.

 

Au W.Y., Cheng T.S., Siu T.S. and Yuen K.Y., Cerebellar degeneration and folate deficiency due to cough misture abuse, Haematologica. 2005, 90:(ECR)28: Epub.

 

Au W.Y., Pang A.W.K., Wan T.S.K., Ma E.S.K., Cheng L.C. and Kwong Y.L., Concomitant post-transplantation lymphoproliferative disease and therapy-related myelodysplastic syndrome after lung transplantation , The Journal of Heart and Lung Transplantation . 2006, 25(2): 259-260.

 

Au W.Y., Tam S., Fong B.M. and Kwong Y.L., Elemental arsenic entered the cerebrospinal fluid during oral arsenic trioxide treatment of meningeal relapse of acute promyelocytic leukemia , Blood. 2006, 107(7): 3012-3013.

 

Au W.Y., Pang A.W.K., Chan C., Chu K.M., Shek T.W.H. and Kwong Y.L., Epstein-barr virus-related gastric adenocarcinoma: an early secondary cancer post hemopoietic stem cell transplantation, Gastroenterology. 2005, 129(6): 2058-63.

 

Au W.Y. and Kwong Y.L., Frequent varicella zoster reactivation associated with therapeutic use of arsenic trioxide: portents of an old scourge, Journal of the American Academy of Dermatology. 2005, 53(5): 890-2.

 

Au W.Y., Kwong Y.L. and Yuen K.Y., Hemophagocytosis in the peripheral blood due to tuberculosis mycobacteremia, American Journal of Medicine. 2005, 118(11): 1298-9.

 

Au W.Y., Lam C.C.K., Liu C.L. and Yuen R.M.F., Hepatitis C virus infection in adult Chinese hemophilia patients negative for the human immunodeficiency virus: treatment results with interferon and ribavirin, International Journal of Hematology. 2005, 82(3): 259-261.

 

Au W.Y., Cheung W.C., Hu H.C., Chan G.C.F., Ha S.Y., Khong P.L., Ma E.S.K. and Liang R.H.S., Hyperbilirubinaemia and cholelithiasis in Chinese patients with hemoglobin H disease., Annals of Hematology. 2005, 84(10): 671-674.

 

Au W.Y., Liu C.L., Lo C.M., Fan S.T. and Lam C.C.K., Living donor liver transplantation for hepatitis C related hepatocellular carcinoma in a haemophilia A patient (Case Report), Haemophilia. 2005, 11(4): 405-407.

 

Au W.Y., Lie A.K.W., Cheng J.W., Liang R.H.S. and Kwong Y.L., Long-term donor health and its relationship with outcome of allogeneic hematopoietic stem cell transplantation, Bone Marrow Transplantation. 2006, 37(5): 451-3.

 

Au W.Y. and Lau L.S., Massive haemolysis because of Clostridium perfringes liver abscess in a patient on peritoneal dialysis, British Journal of Haematology. 2005, 131: 2.

 

Au W.Y., Fung T.K. and Liang R.H.S., Molecular epidemiology of follicular lymphoma in Chinese: relationship with bcl-2IgH translocation and bcl-6 397G/C polymorphism, Annals of Hematology. 2005, 84(8): 506-9.

 

Au W.Y., Chan L.C., Liang R.H.S. and Kwong Y.L., Myelodysplastic syndrome and acute myeloid leukemia after treatment with fludarabine, mitoxantrone, and dexamethasone, American Journal of Hematology. 2006, 81(6): 471-3.

 

Au W.Y. and Kwong Y.L., Peripartum pulmonary embolism in a patient with concomitant hemoglobin Newcastle, hemoglobin Constant Spring, and hereditary spherocytosis, American Journal of Hematology. 2005, 80(2): 166.

 

Au W.Y., Fung T.K., Ma E.S.K., Chan C.H., Wong K.F., Chim J.C.S., Liang R.H.S. and Kwong Y.L., Serial studies of methylation of CDKN2B and CDKN2A in relapsed acute promyelocytic leukaemia treated with arsenic trioxide, British Journal of Haematology. 2005, 131: 632.

 

Au W.Y., Hung K.N., Shek T.W.H. and Ma E.S.K., Side effects related to cancer treatment: CASE 3. Primary cerebral lymphoma after radiotherapy for recurrent meningioma, Journal of Clinical Oncology. 2005, 23(33): 8535-6.

 

Au W.Y., Kumana C.R., Lam C.W., Cheng V.C.C., Shek T.W.H., Chan E.Y.T., Liu K.Y. and Kwong Y.L., Solid tumors subsequent to arsenic trioxide treatment for acute promyelocytic leukemia, Leukemia Research. 2006.

 

Au W.Y., Ma E.S.K., Choy C., Chung L.P., Fung T.K., Liang R.H.S. and Kwong Y.L., Therapy-related lymphomas in patients with autoimmune diseases after treatment with disease-modifying anti-rheumatic drugs, American Journal of Hematology. 2005, 81(1): 5-11.

 

Au W.Y., Cheng V.C.C. and Lie A.K.W., Toxoplasma Gondii Serology and Stem Cell Transplantation in Chinese, Transplantation. 2005, 37(10): 4497-4499.

 

Chen W.Y.W., Hu X., Liang A.C.T., Au W.Y., So J.C.C., Wong M.L.Y., Shen L., Tao Q., Chu K.M., Kwong Y.L., Liang R.H.S. and Srivastava G., High BCL6 expression predicts better prognosis, independent of BCL6 translocation status, translocation partner, or BCL6 deregulating mutations, in gastric lymphoma, Blood. 2006, 108(7): 2373-83.

 

Hon C., Ma E.S.K. and Au W.Y., A patient with anophthalmia, hemifacial microsomia, and hemoglobin anti-Lepore, Annals of Hematology. 2005, 84(9): 623-4.

 

Hon C., Chan R.T., Ma E.S.K., Shek T.W.H., Yau K. and Au W.Y., Lymphomatous proptosis as a novel featur of mantle cell lymphoma, Leukemia & Lymphoma. 2006, 47(1): 71-5.

 

Hon C., Au W.Y. and Cheng V.C.C., Ophthalmic zoster sine herpete presenting as oculomotor palsy after marrow transplantation for acute myeloid leukemia, Haematologica. 2005, 90(12Suppl): EIM04.

 

Hon C., Chui W.H., Cheng L.C., Shek T.W.H., Jones B.M. and Au W.Y., Thymoma associated with keratoconjunctivitis, lichen planus, hypogammaglobinemia, and absent circulating B cells, Journal of Clinical Oncology. 2006, 24(18): 2960-1.

 

Hu X., Liang A.C.T., Chen W.Y.W., Tao Q., Wong M.L.Y., Shen L., Wong K.Y., Au W.Y., Cheung W.L., Chu K.M., Kwong Y.L., Liang R.H.S. and Srivastava G., CD44 expression is regulated by translocation and promoter hypermethylation in gastric lymphoma, Proceedings of the 12th Hong Kong International Cancer Congress and 2nd Annual Meeting of Centre for Cancer Research, Hong Kong SAR, China, December 2005.

 

Hu X., Liang A.C.T., Chen W.Y.W., Tao Q., Au W.Y., Wong M.L.Y., Shen L., Wong K.Y., Wan T.S.K., Cheung W.L., Chu K.M., Chan L.C., Kwong Y.L., Liang R.H.S. and Srivastava G., CD44 expression is regulated by translocation and promoter hypermethylation in gastric lymphoma, Proceedings of 97th Annual Meeting of American Association for Cancer Research (AACR), Washington D.C., USA, April 2006 . 2006.

 

Hui C.K., Lie A.K.W., Au W.Y., Leung A.Y.H., Ma S.Y., Cheung W.W., Zhang H., Chim J.C.S., Kwong Y.L., Liang R.H.S. and Lau G., A long-term follow-up study on hepatitis B surface antigen-positive patients undergoing allogeneic hematopoietic stem cell transplantation, Blood. 2005, 106(2): 464-9.

 

Hui C.K., Cheung W., Au W.Y., Lie A.K.W., Zhang H., Yueng Y.H., Wong B.C.Y., Leung N., Kwong Y.L., Liang R.H.S. and Lau G., Hepatitis B reactivation after withdrawal of preemptive lamivudine in patients with hematological malignancy upon completion of cytotoxic chemotherapy, Liver International 2005. 2005, Oct: 182.

 

Hui C.K., Ma S.Y., Sun J., Au W.Y., Lie A.K.W., Chim J.C.S., Kwong Y.L., Liang R.H.S. and Lau G., Hepatitis B reactivation in patient with occult HBV infection after chemotherapy, J Hepatol. 2005, 42(6): 813-19.

 

Hui C.K., Cheung W.W., Zhang H., Au W.Y., Yueng Y.H., Leung A.Y.H., Leung N., Luk J.M.C., Lie A.K.W., Kwong Y.L., Liang R.H.S. and Lau G., Kinetics and risk of de novo hepatitis B infection in HBsAg negative patients undergoing cytotoxic chemotherapy, Gastroenterology. 2006, 131: 59-68.

 

Hui C.K., Cheung W.W., Zhang H., Au W.Y., Yueng Y.H., Leung A.Y.H., Leung N., Luk J.M.C., Lie A.K.W., Kwong Y.L., Liang R.H.S. and Lau G., Rituximab increases the Risk of De Novo hepatitis B infection in Hepatitis B Surface Antigen Negative Patients Undergoing Cytotoxic Chemotherapy, J Gastroenterol and Hepatol. 2006, 21(2): A73.

 

Kwong Y.L., Chow C., Kumana C.R., Srivastava G. and Au W.Y., Arsenic trioxide in mantle cell lymphoma, Blood (American Society of Hematology 2005 Annual Meeting Abstracts) . 2005, 106 (11): 283B-284B 4814 Part 2 Nov 16 2005.

 

Leung R., Chou E.E., Au W.Y., Chow C., Kwong Y.L., Lin S.Y., Ma E.S.K., Wan T.S.K. and Wong K.F., CD4+/CD56+ hematologic malignancy with rearranged MLL gene, Human Pathology . 2006, 37(2): 247-249.

 

Ooi C.G.C., Chim J.C.S., Au W.Y. and Khong P.L., Radiologic Manifestations of Primary Solitary Extramedullary and Multiple Solitary Plasmacytomas , AJR. American journal of roentgenology. 2006, 186(3): 821-7.

 

Yip B.H., Guo T., Hu X., Wong K.Y., Chen W.Y.W., Au W.Y., Chu K.M., Kwong Y.L., Liang R.H.S. and Srivastava G., Identification of two novel translocations t(14;20)(q32;q12) and t(2;14)(q23;q32) in gastric lymphoma, Proceedings of the 12th Hong Kong International Cancer Congress and 2nd Annual Meeting of Centre for Cancer Research, Hong Kong SAR, China, December 2005.

 

Yip B.H., Guo T., Hu X., Au W.Y., Wong K.Y., Wan T.S.K., Chen W.Y.W., Chu K.M., Chan L.C., Kwong Y.L., Liang R.H.S. and Srivastava G., Identification of two novel translocations t(14;20)(q32;q12) and t(2;14)(q23;q32) involving immunoglobulin heavy chain gene locus in gastric lymphoma, Proceedings of 97th Annual Meeting of American Association for Cancer Research (AACR), Washington D.C., USA, April 2006.

 

Researcher : Chan C



List of Research Outputs

 

Au W.Y., Pang A.W.K., Chan C., Chu K.M., Shek T.W.H. and Kwong Y.L., Epstein-barr virus-related gastric adenocarcinoma: an early secondary cancer post hemopoietic stem cell transplantation, Gastroenterology. 2005, 129(6): 2058-63.

 

Researcher : Chan CK



List of Research Outputs

 

Chan O.O., Hui W.M., Chan C.K., Lai K.C., Hu H.C., Yuen R.M.F., Wong R.W.M., Lau G., Hui C.K., Lam S.K. and Wong B.C.Y., Colonoscopy Demand and Practice in a Regional Hospital over 9 Years in Hong Kong: Resource Implication for Cancer Screening, Gastroenterology. 2006, 130 (4 Suppl 2): A-618.

 

Chan O.O., Hui W.M., Chan C.K., Lai K.C., Hu H.C., Yuen R.M.F., Wong R.W.M., Lau G., Hui C.K., Lam S.K. and Wong B.C.Y., Colonoscopy demand and practice in a regional hospital over 9 years in Hong Kong: Resource implication for cancer screening, Digestion. 2006, 73(2-3): 84-88.

 

Chan O.O., Peng J., Lam S.K., Lai K.C., Yuen R.M.F., Cheung K.L., Kwong Y.L., Rashid A., Chan C.K. and Wong B.C.Y., Eradication of Helicobacter pylori Infection Reverses E-cadherin Promoter Hypermethylation, Gut. 2006, 55: 463-468.

 

Chan O.O., Hui W.M., Hu H.C., Leung G., Chan C.K., Yuen R.M.F., Lam S.K. and Wong B.C.Y., Familial Aggregation in Constipated Subjects in a Tertiary Referral Center, Gastroenterology. 2006, 130 (4 Suppl 2): A-159.

 

Chan O.O., Jim M.H., Lam K.F., Siu D.C.W., Tong S.M., Ng F.H., Hui W.M., Chan C.K., Lai K.C., Hu H.C., Yuen R.M.F., Lau Y.K., Lee S.W.L., Lam S.K. and Wong B.C.Y., Patients with Coronary Artery Disease are at High Risk for Developing Colorectal Cancer and Adenoma: An Interim Analysis of a Prospective Study, Gastroenterology. 2006, 130 (4 Supp 2): A-36.

 

Chan O.O., Hui W.M., Lam K.F., Leung G., Hu H.C., Chan C.K., Yuen R.M.F., Lam S.K. and Wong B.C.Y., The Clinical Characteristics of Patients with Idiopathic Constipation with a Positive Family History, Gastroenterology. 2006, 130 (4 Suppl 2): A-158.

 

Chan O.O., Lam K.F., Hui W.M., Hu W.H., Li J., Lai K.C., Chan C.K., Yuen R.M.F., Lam S.K. and Wong B.C.Y., Validated questionnaire on diagnosis and symptom severity for functional constipation in the Chinese population, Alimentary Pharmacology and Therapeutics. Blackwell Publishing Ltd, 2005, 22: 483-488.

 

Gu Q., Xia H.H.X., Wang J., Wong R.W.M., Chan O.O., Lai K.C., Chan C.K., Yuen R.M.F., Fung F.M.Y., Wong K.W., Lam S.K. and Wong B.C.Y., Update on clarithromycin resistance in Helicobacter pylori in Hong Kong and its effect on clarithromycin-based triple therapy., Digestion. 2006, 72(2-3): 101-106.

 

Wong W.M.R., Gu Q., Chu K.M., Yee Y.K., Fung F.M.Y., Tong S.M., Chan O.O.A., Lai K.C., Chan C.K. and Wong B.C.Y., Lansoprazole, levofloxacin and amoxicillin triple therapy versus quadruple therapy as second-line treatment of resistant Helicobacter pylori infection, Alimentary Pharmacology & Therapeutics. 2006, 23: 421-427.

 

Xia B., Xia H.H.X., Ma C.W., Wong K.W., Fung F.M.Y., Hui C.K., Chan C.K., Chan O.O., Lai K.C., Yuen R.M.F. and Wong B.C.Y., Trends in the prevalence of peptic ulcer disease and Helicobacter pylori infection in family physician-referred uninvestigated dyspeptic patients in Hong Kong. , Alimentary Pharmacology and Therapeutics. 2005, 22(3): 243-9.

 

Xia H.H.X., Wong R.W.M., Chan O.O., Lam S.K., Lai K.C., Chan C.K., Cheung K.L., Fung F.M.Y., Wong K.W. and Wong B.C.Y., Natural acquisition of Helicobacter pylori in adult dyspeptic patients with or without previous infection – a 7-year follow-up study. Australian Gastroenterology Week 2005, 19 October 2005, Australia. , Journal of Gastroenterology and Hepatology. 2005, 20: Supp A112.

 

Researcher : Chan DTM



Project Title:

Internalization of anti-DNA antibodies from patients with lupus nephritis by human mesangial cells

Investigator(s):

Chan DTM, Yung SSY

Department:

Medicine

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

11/2003

 

Abstract:

To characterize HMC membrane and intracellular molecules responsible for binding to anti-DNA antibodies-by trypsin, papain, or pepsin digestion, Western blotting, and protein sequencing; to examine the relationship between the properties of human anti-dsDNA antibodies (isoelectric point, binding to HMC, cellular internalization), their correlation with clinical disease activity, and their effects on cell function, morphology, proliferation, and apoptosis; to elucidate the mechanisms by which anti-dsDNA antibodies bind and penetrate plasma membrane, traverse the cytoplasm, and enter the nucleus of HMC. This will be achieved by kinetic studies using timed flow cytometry, immunohistochemistry, and confocal microscopy. The latter will also be used to investigate the binding between anti-dsDNA antibodies and cytoskeletal structures including myosin. The effects of anti-dsDNA antibodies in the presence or absence of DNA and histones on the synthesis of cytoskeletal molecules will be examined by radiolabelling and immunoprecipitation.

 

Project Title:

Modulation of human mesangial cell F-actin and focal adhesion plaque synthesis in diabetic nephropathy

Investigator(s):

Chan DTM, Yung SSY

Department:

Medicine

Source(s) of Funding:

Small Project Funding

Start Date:

11/2003

Completion Date:

10/2005

 

Abstract:

To examine the effect of physiological (5mM) and elevated (10mM and 30mM) D-glucose concentrations on cultured human mesangial cells (HMC) viability, proliferation, and activation - the latter will be determined by [alpha]-smooth muscle actin staining; to determine how physiological and elevated glucose concentrations modulate F-actin, [alpha]-actinin, vinculin and PKC expression; to determine the morphological changes of HMC cytoskeletal components by scanning and transmission electron microscopy.

 

Project Title:

Internalization of anti-DNA antibodies from patients with lupus nephritis by human mesangial cells

Investigator(s):

Chan DTM, Yung SSY

Department:

Medicine

Source(s) of Funding:

Merit Award for RGC CERG Funded Projects

Start Date:

11/2003

 

Abstract:

N/A

 

Project Title:

The effect of anti-DNA antibodies on the synthesis of pro-fibrotic cytokines, growth factors and matrix proteins in proximal tubular epithelial cells during lupus nephritis

Investigator(s):

Chan DTM, Yung SSY

Department:

Medicine

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

Completion Date:

10/2006

 

Abstract:

To isolate paired polyclonal anti-DNA antibodies from 12 patients with a history of clinically severe lupus nephritis during disease flare and remission; to determine the effect of human polyclonal anti-DNA antibodies on PTEC viability, proliferation and activation; to determine the effect of anti-DNA antibodies on PTEC secretion of cytokines; to investigate how anti-DNA-mediated alterations of cytokines and growth factors modulate changes in matrix synthesis and deposition.

 

Project Title:

Effects of mycophenolate mofetil and cyclophosphamide on mesangial cell proliferation and function in MRL/1pr mice with lupus nephritis

Investigator(s):

Chan DTM, Yung SSY

Department:

Medicine

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

12/2004

 

Abstract:

To assess the clinical effects of mycophenolate mofetil (MMF) and cyclophosphamide on disease manifestations in MRL/1pr mice with lupus nephritis; to determine the effects of MMF and cyclophosphamide on serum levels of anti-DNA antibodies, pro-inflammatory mediators, and markers of fibrosis; to examine the effects of MMF and cyclophosphamide on kidney histopathology in MRL/1pr mice with lupus nephritis, focusing on mesangial cell proliferation, synthesis of inflammatory/fibrosis mediators, and production of matrix components. The data will be analyzed in relation to corresponding changes in the parameters indicating disease activity, inflammatory cell infiltration, and immune complex deposition; to isolate mesangial cells from treated and control mice, and to assess in vitro mesangial cell activation and synthesis of inflammatory/fibrosis mediators and matrix components; to investigate whether the actions of MMF or cyclophosphamide on mesangial cells are mediated via the protein kinase C (PKC) pathway.

 

Project Title:

Effects of mycophenolate mofetil and cyclophosphamide on mesangial cell proliferation and function in MRL/1pr mice with lupus nephritis

Investigator(s):

Chan DTM

Department:

Medicine

Source(s) of Funding:

Merit Award for RGC CERG Funded Projects

Start Date:

01/2005

 

Abstract:

N/A

 

Project Title:

Interaction between anti-DNA antibodies and renal tubular epithelial cells in the pathogenesis of tubulo-interstitial damage in lupus nephritis

Investigator(s):

Chan DTM

Department:

Medicine

Source(s) of Funding:

Incentive Award for RGC CERG Fundable But Not Funded Projects

Start Date:

07/2005

Completion Date:

06/2006

 

Abstract:

N/A

 

Project Title:

TGF-beta1 bioactivation in human peritoneal mesothelial cells under elevated glucose concentration - the role of thrombospondin-1

Investigator(s):

Chan DTM, Yung SSY

Department:

Medicine

Source(s) of Funding:

Small Project Funding

Start Date:

12/2005

 

Abstract:

Background In Hong Kong, 80% of patients with end stage renal failure are managed with peritoneal dialysis (PD). Normal structure and function of the peritoneum are essential to ensure optimal long-term clinical outcome. Many patients on long-term PD however, develop progressive thickening of the peritoneal membrane with altered transport function. The peritoneum is the most extensive serous membrane in the body, covering the visceral organs and lining the abdominal cavity. It comprises a monolayer of mesothelial cells resting upon a thin basal lamina, underneath which is the interstitium that contains a capillary network and fibroblasts (1). Mesothelial cells are specialized epithelial cells that provide an anatomical barrier and a frictionless interface for the movement of organs and tissues (2). They also play a critical role in the control of peritoneal homeostasis, permselectivity, inflammation and fibrosis. Moreover, mesothelial cells synthesize and secrete multifunctional molecules including matrix proteins and glycosaminoglycans including hyaluronan (HA) (3). During PD a hyperosmolar dialysis solution is allowed to dwell in the peritoneal cavity for several hours. Metabolic waste, electrolytes, and excessive water are removed from the circulation by diffusion or convection across the peritoneal membrane (4, 5). Conventional PD solutions utilize dextrose at high concentrations, usually 15 to 40 times that of physiological levels, to provide the osmotic drive for free water removal. This ‘bio-incompatible’ glucose milieu is a major insult to the structural and functional integrity of the peritoneal membrane (6, 7). The peritoneum in long-term PD exhibits re-duplication of the basal lamina, increased synthesis and deposition of matrix within the submesothelium, and progressive subendothelial hyalinization, with narrowing or obliteration of the vascular lumen (6-8). These structural changes are accompanied by deranged transport properties. In vitro studies have shown that high glucose concentrations alter cellular proliferation and viability, and induce growth factor, cytokine and matrix protein synthesis in human peritoneal mesothelial cells (HPMC) (9-13). Repeated chemical or bacterial injury to the peritoneal mesothelium triggers inflammatory responses and initiates a multitude of reparative processes that aim to heal but which often result in fibrosis. The mechanisms leading to the different outcomes are under intense investigation. In vitro studies have demonstrated that high glucose concentration can modulate cell proliferation and up-regulate matrix synthesis in HPMC. These changes are mediated through protein kinase C, and bioactivation of TGF-beta1. TGF-beta1 is normally synthesized and secreted in its latent form, and must be activated before it can bind to its receptors and elicit functional changes to the cells. Therefore, changes in the expression of latent TGF-beta1 will have no biological effect on HPMC unless mechanisms are present to convert it to its active form. Studies utilizing platelets and endothelial cells have demonstrated that physiocochemical activation of TGF-beta1 can occur by extreme pH or high temperature, limited proteolysis, or binding to various membrane or extracellular matrix components (14, 15). Activation in vivo is more complex and remains to be fully elucidated. Recent studies have demonstrated that the extracellular matrix component thrombospondin-1 (TSP-1) is a key activator of TGF-beta1 in human mesangial cells incubated with elevated concentrated of glucose (16). The mechanism by which TGF-beta1 is activated in HPMC has not been investigated and constitutes the theme of this project. The objectives of this proposal are thus: 1. To assess HPMC proliferation and cell viability under physiological (5mM) and elevated glucose concentrations (30 mM which simulates the concentration of glucose in the peritoneal cavity after equilibration of the PD solution). 2. To determine mRNA and protein synthesis of TGF-beta1, TSP-1 and matrix proteins (fibronectin, and collagen type I and III and IV). TGF-beta1 bioactivation will also be assessed and correlated with TSP-1 expression. 3. To examine the effect of exogenous TSP-1 on TGF-beta1 activity, matrix synthesis, and PKC-signaling pathway. Data will be confirmed in separate studies whereby TSP-1 blocking peptide will be used. References 1. Dobbie JW. In: Gokal R, Nolph KD, Eds. The Textbook of Peritoneal Dialysis. Kluwer Academic Publishers, Netherlands, 1994. 2. Digenis GE. Perit Dial Bull 1984; 4: 63-69. 3. Mutsaers SE. Respirology 2002; 7: 171-191. 4. Moncrief JW, Popovich RP. Kidney Int 1985; 17: S23-S25. 5. Krediet R. In: Gokal R, Khanna R, Krediet R Eds. The Textbook of Peritoneal Dialysis. Kluwer Academic Publishers, Dordrechts, 2000: 135-172. 6. Honda K, Nitta K, Horita S, Yumura W, Nihei H. Nephron 1996; 72: 171-176. 7. Williams JD, Craig KJ, Topley N, et al. J Am Soc Nephrol 2002; 13: 470-479. 8. Gotloib L, Bar-Sella P, Shostak A. Perit Dial Bull 1985; 5: 212-215. 9. Topley N, Mackenzie R, Jorres A, Coles GA, Davies M, Williams JD. Perit Dial Int 1992; 13: S282-285. 10. Ha H, Yu MR, Lee HB. Kidney Int 2001; 59: 463-470. 11. Chan TM, Leung JKH, Tsang RCW, Liu ZH, Li LS, Yung S. Kidney Int 2003; 64: 519-533. 12. Topley N, Liberek T, Davenport A, Li FK, Fear H, Williams JD. Kidney Int Suppl 1996; 56: S17-21. 13. Witowski J, Wisniewska J, Korybalska K, et al. J Am Soc Nephrol 2001; 12: 2434-2441. 14. Brown PD, Wakefield LM, Levinson AD, Sporn MB. Growth Factors. 1990; 3: 35-43. 15. Lyons R, Gentry LE, Purchio AF, Moses HL. J Cell Biol 1990; 110; 1361-1367. 16. Yevdokimova N, Abdel Wahab N, Mason RM. J Am Soc Nephrol 2001; 12: 703-712.

 

List of Research Outputs

 

Chan D.T.M., Determinants of patient survival in systemic lupus erythematosus – focusing on lupus nephritis, Ethnicity and Disease. 2006, 16(Suppl 2): 66-69.

 

Chan D.T.M., Electrolyte disorders, In Integrated Systematic Nephrology. Hong Kong, HKU Press, 2006, 3rd ed: 19-26.

 

Chan D.T.M., Hepatitis B and dialysis, In UpToDate CD-ROM and Web-based series of CME program, endorsed by American Society of Nephrology and Society of Internal Medicine, U.S.A. (since 2002). USA, ASN and SIN, 2006.

 

Chan D.T.M., Histological reclassification of lupus nephritis, Current opinion in nephrology and hypertension. 2005, 14: 561-566.

 

Chan D.T.M. and Chan M.K., Integrated Systematic Nephrology. Hong Kong, HKU Press, 2006, 3rd ed.

 

Chan D.T.M., Lupus Nephritis, In: Hai-yan Wang, 肾脏病学, 2005, TBA.

 

Chan D.T.M., Tsang R.C.W., Zhang Q. and Yung S.S.Y., Mycophenolic Acid Reduces Matrix Synthesis in Human Mesangial Cells Stimulated with Anti-DNA Antibodies, Journal of the American Society of Nephrology. 2005, 16: 420A.

 

Chan D.T.M., Normal structure and function of the kidneys, In Integrated Systematic Nephrology. Hong Kong, HKU Press, 2006, 3rd ed: 1-10.

 

Chan D.T.M. and Chan M.K., Renal transplantation, In Integrated Systematic Nephrology. Hong Kong, HKU Press, 2006, 3rd ed: 173-182.

 

Chan D.T.M., Survival in patients with lupus nephritis, Post-ICN Satellite Meeting on Renal Diseases in Ethnic Groups, July 1-2, 2005, National Kidney Foundation, Singapore. 2005.

 

Chan D.T.M., Water metabolism, hyponatraemia, and hypernatraemia, In Integrated Systematic Nephrology. Hong Kong, HKU Press, 2006, 3rd ed: 27-34.

 

Choy C.B.Y., Chan D.T.M., Tse K.C., Lam M.F. and Lai K.N., Mycophenolic acid increase risk of herpes zoster infection in renal transplant recipients, Journal of American Society of Nephrology. 2005, 16: 835A.

 

Kwong Y.L., Lau W.C.S., Ho S.L., Epstein R., Young R.T.T., Chan H.H.L., Tse H.F., Lam L., Chen W.H., Lee K.L.F., Ip M.S.M., Tsang K.W.T., Lam B., Tang S.C.W., Chan R.H.W., Lee S.W.L., Tan K.C.B., Yeung C.K., Chan D.T.M., Wong R.W.S., Choy C.B.Y., Wong B.C.Y., Li F.K., Lo W.K., Lui S.L., Cheung R.T.F., Mak W., Ho J.C.M., Mok T.M.Y., Kung A.W.C., Cheung B.M.Y., Chow W.S., Yuen R.M.F. and Wat N.M.S., In: Lau CP, Kumana CR, Lai CL, Lai KN, Lam KSL, Lam WK, Problem-Based Medical Case Management. Hong Kong, Hong Kong University Press, 2005.

 

Lam M.F., Leung J.C.K., Lo W.K., Lui S.L., Chan D.T.M. and Lai K.N., Increased serum leptin levels during peritoneal dialysis related peritonitis associated with prolonged inflammation and loss of lean body mass, Journal of American Society of Nephrology. 2005, 16: 713A.

 

Lam M.F., Leung J.C.K., Tang C.S.O., Lo W.K., Tse K.C., Yip T.P.S., Lui S.L., Chan D.T.M. and Lai K.N., Mannose binding lectin level and polymorphism in patients on long-term peritoneal dialysis, Nephrology Dialysis Transplantation. 2005, 20: 2489-2496.

 

Leung J.C.K., Chan L.Y., Li F.K., Tang S.C.W., Chan K.W., Chan D.T.M., Lam M.F., Wieslander A. and Lai K.N., Glucose degradation products downregulate ZO-1 expression in human peritoneal mesothelial cells: the role of VEGF, Nephrology Dialysis Transplantation. 2005, 20(7): 1336-1349.

 

Lui S.L., Chan K.W., Tsang R.C.W., Yung S.S.Y., Lai K.N. and Chan D.T.M., Effect of rapamycin on renal ischemia reperfusion injury, Joint symposium on extracorporeal support for multi-organ failure organized by Hong Kong College of Physicians Scientific Symposium and Hong Kong Society of Nephrology Annual Scientific Meeting, 10-11 September 2005, Hong Kong. 2005.

 

Mok T.M.Y., Wong S.Y., Chan D.T.M., Tang W.M., Wong R.W.S. and Lau W.C.S., Necrotising Fasciitis in Rheumatic Diseases, Lupus. 2006, 15: 380-3.

 

Ng M.W., Lau W.C.S., Chan D.T.M., Wong W.H.S. and Lau Y.L., Polymorphisms of the toll-like receptor 9 (TLR9) gene with systemic lupus erythematosus in Chinese., Rheumatology. 2005, 44(11): 1456-1457.

 

Tse K.C., Tang S.C.W., Tang C.S.O., Lai K.N., Li F.K. and Chan D.T.M., Angiotensin inhibition or blockade for the treatment of patients with quiescent lupus nephritis and persistent proteinuria, Lupus. 2005, 14(12): 947-952.

 

Tse K.C., Tang C.S.O., Lio W.I., Lam M.F. and Chan D.T.M., Quality of life comparison between corticosteroid-and-mycofenolate mofetil and corticosteroid-and-oral cyclophosphamide in the treatment of severe lupus nephritis, Lupus. 2006, 15(6): 371-379.

 

Wong A.K.M. and Chan D.T.M., Obstructive uropathy, In Integrated Systematic Nephrology. Hong Kong, HKU Press, 2006, 3rd ed: 47-52.

 

Yip T.P.S., Tse K.C., Lam M.F., Tang S.C.W., Li F.K., Choy C.B.Y., Lui S.L., Chan D.T.M., Lai K.N. and Lo W.K., Risk factors and outcomes of extended-spectrum beta-lactamase-producing E. coli peritonitis in CAPD patients, Peritoneal Dialysis International. 2006, 26(2): 191-197.

 

Yung S.S.Y., Zhang Q., Tsang R.C.W. and Chan D.T.M., Binding and internalisation of anti-DNA antibodies induce altered cellular functions in human mesangial cells - implications in the pathogenesis of lupus nephritis, 11th Medical Research Conference, 14 January, 2006. 49.

 

Yung S.S.Y., Tsang R.C.W., Sun Y., Leung J.K.H. and Chan D.T.M., Effect of Human Anti-DNA Antibodies on Proximal Renal Tubular Epithelial Cell Cytokine Expression: Implication on Tubulointerstitial Inflammation in Lupus Nephritis, Journal of the American Society of Nephrology. 2005, 16: 3281-3294.

 

Yung S.S.Y., Lee Y.Y.C., Zhang Q., Leung J.K.H., Lau S.K., Tsang R.C.W. and Chan D.T.M., Elevated glucose concentrations induce thrombospondin-1 synthesis in proximal renal tubular epithelial cells thereby stimulating fibronectin synthesis through TGF-b1 dependent and TGF-b1 independent pathways, Nephrology Dialysis Transplantation. 2006, 21: 1504-1513.

 

Yung S.S.Y. and Chan D.T.M., Glucose degradation products and the peritoneum - how sweet things can turn bitter, Peritoneal Dialysis International. 2006, 26: 309-313.

 

Yung S.S.Y., Tsang R.C.W., Leung J.K.H. and Chan D.T.M., Increased mesangial cell hyaluronan expression during active lupus nephritis is mediated by anti-DNA antibody-induced IL-1beta, Kidney International. 2006, 69(2): 272-280.

 

Yung S.S.Y., Li F.K. and Chan D.T.M., Peritoneal mesothelial cell culture and biology, Peritoneal Dialysis International. 2006, 26(2): 162-173.

 

Yung S.S.Y., Lee Y.Y.C., Zhang Q., Tsang R.C.W. and Chan D.T.M., Thrombospondin-1 Induced by High Glucose Concentration Mediates Fibronectin Synthesis in Proximal Renal Tubular Epithelial Cells Through Both TGF-beta1 Dependent and TGF-beta1 Independent Pathways, Journal of the American Society of Nephrology. 2005, 16: 662A.

 

Researcher : Chan FHW



List of Research Outputs

 

Chan M.M.W., Chan F.H.W., Cheung A.H.K., Dai D.L., Chu L.W., Lam W.K., Leung C.C., Kam K.M. and Tam C.M., Prevalence of tuberculous infection and active tuberculosis in old age homes in Hong Kong., Journal of the American Geriatrics Society. 2006, 54: 1334-40.

 

Researcher : Chan H



List of Research Outputs

 

Tse H.F., Siu C.W.D., Lee K.L.F., Fan K., Chan H., Tang M.O., Tsang V.Y.C., Lee S.W.L. and Lau C.P., The incremental benefit of rate-adaptive pacing on exercise performance during cardiac resynchronization therapy., J Am Coll Cardiol . 2005, 46(12): 2292-7.

 

Researcher : Chan HHL



Project Title:

The role of epidermal cooling in improving the outcome of laser therapy in the treatment of Nevus of Ota

Investigator(s):

Chan HHL, Lam LK

Department:

Medicine

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

12/2000

 

Abstract:

To assess whether epidermal cooling would reduce pain, swelling, complications but improve clinical response and reduce the number of session required for laser treatment for Nevus of Ota.

 

Project Title:

The use of vascular lasers in the treatment of port wine stain in chinese

Investigator(s):

Chan HHL, Wei WI

Department:

Medicine

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

11/2001

 

Abstract:

To establish the importance of epidermal cooling when 585nm pulse dye laser is used for the treatment of port wine stain in Chinese; to compare the clinical efficacy, patients' tolerability and complications of two commerical available vascular lasers that are equipped with different cooling devices in the treatment of port wine stain in Chinese.

 

List of Research Outputs

 

Kwong Y.L., Lau W.C.S., Ho S.L., Epstein R., Young R.T.T., Chan H.H.L., Tse H.F., Lam L., Chen W.H., Lee K.L.F., Ip M.S.M., Tsang K.W.T., Lam B., Tang S.C.W., Chan R.H.W., Lee S.W.L., Tan K.C.B., Yeung C.K., Chan D.T.M., Wong R.W.S., Choy C.B.Y., Wong B.C.Y., Li F.K., Lo W.K., Lui S.L., Cheung R.T.F., Mak W., Ho J.C.M., Mok T.M.Y., Kung A.W.C., Cheung B.M.Y., Chow W.S., Yuen R.M.F. and Wat N.M.S., In: Lau CP, Kumana CR, Lai CL, Lai KN, Lam KSL, Lam WK, Problem-Based Medical Case Management. Hong Kong, Hong Kong University Press, 2005.

 

Nordlund J.J., Ortonne J.P., Cestari T., Grimes P. and Chan H.H.L., Confusions about color: formulating a more precise lexicon for pigmentation, pigmentary disorders, and abnormalities of "chromatics", In: Nordlund J.J., Ortonne J.P., Cestari T., Grimes P., Chan H.H.L., Journal of the American Academy of Dermatology . 2006, 54(5 Suppl 2): S291-7.

 

Researcher : Chan JCK



Project Title:

Application of the APACHE II and III prognostic scoring methods in the 14-bed Intensive Care Unit at Queen Mary Hospital

Investigator(s):

Chan JCK, Lam WK

Department:

Medicine

Source(s) of Funding:

Health Services Research Fund - Full Grants

Start Date:

07/1995

 

Abstract:

To evaluate the usefulness of the APACHE II and III prognostic scoring methods in the 14-bed ICU at Queen Mary Hospital; to compare our ICU performance in terms of actual mortality with the predicted mortality based on the APACHE II predictive equation; to correlate the APACHE II and III severity scores. As the mortality prediction equation for APACHE III is only commercially available, a close correlation between APACHE II and III scores would support using the APACHE II scoring and prediction method as the standard method rather than financially investing in the APACHE III system.

 

List of Research Outputs

 

Researcher : Chan K



List of Research Outputs

 

Chan K., Sasanakul W., Mellars G., Chuansumrit A., Perry D., Lee C.A., Wong M.S., Chan T.K. and Chan V.N.Y., Detection Of Known Haemophilia B Mutations And Carrier Testing By Microarray., Thrombosis and Haemostasis.. 2005, 94: 872-878.

 

Researcher : Chan KH



List of Research Outputs

 

Chan K.H., Mak W., Cheung R.T.F., Cheng T.S. and Ho S.L., Muscle-specific kinase autoantibody in acetylcholine receptor antibody-negative generalized acquired myasthenia gravis, 11th Medical Research Conference, Medical Science Group. 2006, 80.

 

Chan K.H., Neuromyelitis optica is more common than classical multiple sclerosis after acute transverse myelitis, European Journal of Neurology. 2005, 12: 139.

 

Fong C.Y.G., Cheng T.S., Lam K., Cheng W.K., Mok B.K.Y., Cheung C.M., Chim J.C.S., Mak W., Chan K.H., Tsang K.L., Kwan M.C., Tsoi T.H., Cheung R.T.F. and Ho S.L., An epidemiological study of motor neuron disease in Hong Kong, Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. 168, 2005, 6: 164.

 

Hui S.L., Chu L.W., Peiris J.S.M., Chan K.H., Chu D. and Tsui W., Immune response to influenza vaccination in community-dwelling Chinese elderly persons., Vaccine. 2006, 24(25): 5371-80.

 

Mak W., Kwan M.W., Cheng T.S., Chan K.H., Cheung R.T.F. and Ho S.L., Cerebrospinal fluid to serum glucose ratio in non-hypoglycorrhachic conditions, Hong Kong Medical Journal. 2005, 11: 457-462.

 

Mak W., Kwan M.W.M., Cheng T.S., Chan K.H., Cheung R.T.F. and Ho S.L., Myopia as a latent phenotype of a pleiotropic gene positively selected for facilitating neurocognitive development, and the effects of environmental factors in its expression, Medical Hypotheses. 2006, 6: 1209-1215.

 

Ng M.C., Ho J.T., Ho S.L., Lee R., Li G., Song Y., Chan K.H., Cheng T.S., Yang E.S. and Leong L.Y., Asymptomatic members with SOD1 mutation in a large kindred with familial amyotrophic lateral sclerosis have abnormal water diffusion characterisitcs., The International Society for Magnetic Resonance in Medicine (ISMRM2006). 6-12 May 2006, Seattle, Washington, USA. 2006.

 

Researcher : Chan KH



List of Research Outputs

 

Chan K.H., Mak W., Cheung R.T.F., Cheng T.S. and Ho S.L., Muscle-specific kinase autoantibody in acetylcholine receptor antibody-negative generalized acquired myasthenia gravis, 11th Medical Research Conference, Medical Science Group. 2006, 80.

 

Chan K.H., Neuromyelitis optica is more common than classical multiple sclerosis after acute transverse myelitis, European Journal of Neurology. 2005, 12: 139.

 

Fong C.Y.G., Cheng T.S., Lam K., Cheng W.K., Mok B.K.Y., Cheung C.M., Chim J.C.S., Mak W., Chan K.H., Tsang K.L., Kwan M.C., Tsoi T.H., Cheung R.T.F. and Ho S.L., An epidemiological study of motor neuron disease in Hong Kong, Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. 168, 2005, 6: 164.

 

Hui S.L., Chu L.W., Peiris J.S.M., Chan K.H., Chu D. and Tsui W., Immune response to influenza vaccination in community-dwelling Chinese elderly persons., Vaccine. 2006, 24(25): 5371-80.

 

Mak W., Kwan M.W., Cheng T.S., Chan K.H., Cheung R.T.F. and Ho S.L., Cerebrospinal fluid to serum glucose ratio in non-hypoglycorrhachic conditions, Hong Kong Medical Journal. 2005, 11: 457-462.

 

Mak W., Kwan M.W.M., Cheng T.S., Chan K.H., Cheung R.T.F. and Ho S.L., Myopia as a latent phenotype of a pleiotropic gene positively selected for facilitating neurocognitive development, and the effects of environmental factors in its expression, Medical Hypotheses. 2006, 6: 1209-1215.

 

Ng M.C., Ho J.T., Ho S.L., Lee R., Li G., Song Y., Chan K.H., Cheng T.S., Yang E.S. and Leong L.Y., Asymptomatic members with SOD1 mutation in a large kindred with familial amyotrophic lateral sclerosis have abnormal water diffusion characterisitcs., The International Society for Magnetic Resonance in Medicine (ISMRM2006). 6-12 May 2006, Seattle, Washington, USA. 2006.

 

Researcher : Chan KKC



List of Research Outputs

 

Lee P.W.H., Stewart S.M. and Chan K.K.C., Hong Kong, SAR China: transitions and return to the motherland, In: James Georgas, John W Berry, Fons J R van de Vijver, Cigdem Kagitcibasi, and Ype H Poortinga, Families Across Cultures, A 30-Nation Psychological Study. Cambridge University Press, 2006, 353-361.

 

Wong J.G.W.S., Cheung E.P.T., Chan K.K.C., Ma K.K.M. and Tang S.W., Web-based survey of depression, anxiety and stress in first-year tertiary education students in Hong Kong., Australian and New Zealand Journal of Psychiatry. 2006, 40: 777-782.

 

Researcher : Chan KW



List of Research Outputs

 

Wang Y., Lam K.S.L., Chan L., Chan K.W., Lam J.B.B., Lam C.W., Hoo R.L.C., Mak W.W., Cooper G.J. and Xu A., Post-translational modifications of the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high molecular weight oligomeric complex, J Biol Chem. 2006, 281: 16391-400.

 

Wang Y., Lam K.S.L., Chan L., Chan K.W., Lam J.B.B., Lam C.W., Hoo R.L.C., Mak W.W., Cooper G.J.S. and Xu A., Posttranslational modifications on the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high-molecular-weight oligomeric complex, J Biol Chem. 2006.

 

Researcher : Chan KY



List of Research Outputs

 

Tam T.C., Chan K.Y., Ho S.L., Luk J.K.H. and Chu L.W., Herpetic shoulder paresis in a Chinese elderly patient., Hong Kong Medical Journal. 2005, 11: 399-402.

 

Researcher : Chan LY



List of Research Outputs

 

Chan L.Y., Leung J.C.K., Tang S.C.W. and Lai K.N., Glucose modulates leptin and adiponectin synthesis by human peritoneal omental adipocyte, Journal of American Society of Nephrology. 2005, 16: 791A.

 

Chan L.Y., Leung J.C.K., Tang S.C.W., Choy C.B.Y. and Lai K.N., Tubular expression of angiotensin II receptors and their regulation in IgA nephropathy, Journal of American Society of Nephrology. 2005, 16(8): 2306-2317.

 

Guo H., Leung J.C.K., Chan L.Y., Lui S.L., Tsang W.L. and Lai K.N., Modulation of intra-pulmonary TGF-beta expression by mycophenolate mofetil in lupus prone MRL/lpr mice, Lupus. 2005, 14(8): 583-592.

 

Lai K.N., Tang S.C.W., Chan L.Y. and Leung J.C.K., Monocytes/T cells modulate chemokine release and chemokine receptor expression in proximal tubular epithelial cells in proteinuric state, Journal of American Society of Nephrology. 2005, 16: 642A.

 

Leung J.C.K., Chan L.Y., Li F.K., Tang S.C.W., Chan K.W., Chan D.T.M., Lam M.F., Wieslander A. and Lai K.N., Glucose degradation products downregulate ZO-1 expression in human peritoneal mesothelial cells: the role of VEGF, Nephrology Dialysis Transplantation. 2005, 20(7): 1336-1349.

 

Leung J.C.K., Chan L.Y., Tang S.C.W. and Lai K.N., Glycosylation profile of anionic polymeric IgA and their binding characteristics to cultured mesangial cells in IgA nephropathy, Journal of American Society of Nephrology. 2005, 16: 49A.

 

Tang S.C.W., Leung J.C.K., Chan L.Y., Lui Y.H., Tang C.S.O., Kan C.H., Ho Y.W. and Lai K.N., Mycophenolate mofetil alleviates persistent proteinuria in IgA nephropathy, Kidney International. 2005, 68(2): 802-812.

 

Tang S.C.W., Leung J.C.K., Chan L.Y., Tsang W.L. and Lai K.N., Role of PPAR-g agonist in diabetic nephropathy: An in vivo study, Journal of American Society of Nephrology. 2005, 16: 613A.

 

Zhong Q., Leung J.C.K., Chan L.Y., Tsang W.L., Chen X. and Lai K.N., The study of Chinese medicinal herbal formula Shen San Fang in the treatment of experimental IgA nephropathy, the American Journal Of Chinese Medicine. 2005, 33(4): 613-626.

 

Researcher : Chan MMW



Project Title:

A surveillance program of tuberculosis in old age homes in Hong Kong

Investigator(s):

Chan MMW, Chu LW, Lam WK, Wong C.P., Kam K.M., Dai D.L.K.

Department:

Medicine

Source(s) of Funding:

S.K. Yee Medical Foundation - General Award

Start Date:

11/2001

 

Abstract:

To conduct a cross-sectional screening examination for tuberculosis in old age homes in several districts in Hong Kong, SAR; to ensure that directly observed therapy (DOT) is given to those with active disease diagnosed through the screening program in collaboration with the Hong Kong Government Tuberculosis and Chest Service (Chest Service); to provide a screening examination for tuberculosis for new residents on entry to the old age homes participating in the program; to participate, in collaboration with the Chest Service, in contact examination on residents in the same home from which an active case of tuberculosis is being diagnosed; to provide education to the staff of old age homes on early recognition of tuberculosis, its treatment and possible side effects to evaluate the effectiveness of the program.

 

Project Title:

A surveillance program of tuberculosis in old age homes in Hong Kong

Investigator(s):

Chan MMW, Chu LW, Lam WK, Dai D.L.K., Wong C.P., Kam K.M.

Department:

Medicine

Source(s) of Funding:

S.K. Yee Medical Foundation - General Award

Start Date:

01/2004

 

Abstract:

To conduct a cross-sectional screening examination for tuberculosis in old age homes in several districts in Hong Kong, SAR; to ensure that directly observed therapy (DOT) is given to those with active disease diagnosed through the screening program in collaboration with the Hong Kong Tuberculosis and Chest Service, Department of Health (Chest Service); to provide a screening examination for tuberculosis for new residents on entry to the old age homes participating in the program; to participate, in collaboration with the Chest Service, in contact examination on residents in the same home from which an active case of tuberculosis is being diagnosed; to provide education to the staff of old age homes on early recognition of tuberculosis, its treatment and possible side effects; to evaluate the effectiveness of the program.

 

List of Research Outputs

 

Becker A., Gie R.P. and Chan M.M.W., Management of childhood asthma. , International Journal of Tuberculosis and Lung Disease. 2006, 10(6): 592-9.

 

Bernstein I.L., Chan M.M.W., Malo J.L. and Berstein D.I., Asthma in Workplace, 3rd edition. New York, Francis and Taylor, 2006.

 

Beyers N. and Chan M.M.W., The IJTLD - Open Access - 2005, International Journal of Tuberculosis and Lung Disease. 2006, 10: 2.

 

Beyers N., Pierard C., Enarson D.A. and Chan M.M.W., What new knowledge did we gain through the International Journal of Tuberculosis and Lung Disease in 2005? , International Journal of Tuberculosis and Lung Disease. 2006, 10(2): 119-23.

 

Bouayad Z., Aichane A., Afif A., Benouhoud N., Trombati N., Chan M.M.W. and Ait-Khaled N., Prevalence and trend of self-reported asthma and other allergic disease symptoms in Morocco: ISAAC phase I and III. , International Journal of Tuberculosis and Lung Disease. 2006, 10(4): 371-7.

 

Chan M.M.W. and FitzGerald J.M., A framework for achieving better asthma control: introducing two new series in the journal. , International Journal of Tuberculosis and Lung Disease. 2006, 10(2): 124.

 

Chan M.M.W., Chan F.H.W., Cheung A.H.K., Dai D.L., Chu L.W., Lam W.K., Leung C.C., Kam K.M. and Tam C.M., Prevalence of tuberculous infection and active tuberculosis in old age homes in Hong Kong., Journal of the American Geriatrics Society. 2006, 54: 1334-40.

 

Chan M.M.W. and Becker A., Primary prevention of childhood asthma and allergic disorders. , Curr Opin Allergy Cin Immunol. 2006, 6(3): 146-51.

 

Chan M.M.W., Yeh A.G.O., Tam C.M., Kam K.M., Leung C.C., Yew W.W. and Lam C.W., Socio-demographic and geographic indicators and distribution of tuberculosis in Hong Kong: a spatial analysis. , International Journal of Tuberculosis and Lung Disease. 2005, 9(12): 1320-6.

 

Ho J.C.M., Mak J.C.W., Ho S., Ip M.S.M., Tsang K.W.T., Lam W.K. and Chan M.M.W., Manganese superoxide dismutase and catalase genetic polymorphisms, activity levels and lung cancer risk in Chinese in Hong Kong. 11th World Conference on Lung Cancer , Lung Cancer. 2005, 49(Suppl 2): S191.

 

Ip M.S.M., Ko F.W., Lau C.W., Yu W.C., Choo K., Tang K.S. and Chan M.M.W., Update reference values of spirometry for adult Chinese in Hong Kong and implications on clinical ulilisation, Chest. 2006, 129: 384-392.

 

Ko F. and Chan M.M.W., Tobacco Control in Hong Kong., Newsletter. Hong Kong Thoracic Society and AACP (HK and Macau Chapter). 2005, 14.

 

Mak J.C.W., Leung C.M., Ho S.P., Law K.W., Ho A.S.S., Lam W.K., Ip M.S.M. and Chan M.M.W., Analysis of transforming growth factor-beta(1) gene polymorphisms in Hong Kong Chinese asthmatic patients, Journal of Allergy and Clinical Immunology. 2006, 117: 92-96.

 

Mak J.C.W., Leung C.M., Ho S.P., Law K.W., Tsang K.W.T., Lam W.K., Ip M.S.M. and Chan M.M.W., Best Poster - Genetic Susceptibility Of Transforming Growth Factor-beta1 Common Polymorphisms To Chinese Patients With Asthma, Hong Kong Allergy Convention 2005 . 2005.

 

Mak J.C.W., Leung C.M., Ho S.P., Law K.W., Tsang K.W.T., Lam W.K., Ip M.S.M. and Chan M.M.W., Genetic susceptibility of transforming growth factor-beta(1) common polymorphisms to Chinese patients with asthma, Hong Kong Allergy Convention, Hong Kong. 2005, Abstract AB25: p.54.

 

Mak J.C.W., Ho S.P., Leung C.M., Lam W.K., Ip M.S.M. and Chan M.M.W., Genetic susceptibility to chronic obstructive pulmonary disease (COPD) : Transforming growth factor-beta common polymorphisms and plasma levels, American Journal of Respiratory and Critical Care Medicine. 2006, 173(3): A624.

 

Mak J.C.W., Ho S.P., Leung C.M., Lam W.K., Ip M.S.M. and Chan M.M.W., Genetic susceptibility to chronic obstructive pulmonary disease (COPD) : transforming growth factor-beta(1) common polymorphisms and plasma levels, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong, January 2006. Abstract Book 089: pp.56.

 

Mak J.C.W., Hui W.S., Ho S.P., So W.H.L., Chan M.M.W., Cho C.H. and Lam W.K., Inducation of CINC-1 in the lung tissue from rats exposed to cigarette smoke, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2006, Abstract Book 088: pp. 55.

 

Mak J.C.W., Hui W.S., Ho S.P., So W.H., Chan M.M.W., Cho C.H. and Lam W.K., Induction of CINC-1 in the lung tissue from rats exposed to cigarette smoke, American Journal of Respiratory and Critical Care Medicine. 2006, 173(3): A634.

 

Mak J.C.W., Leung C.M., Ho S.P., Ko F.W.S., Cheung A.H.K., Ip M.S.M. and Chan M.M.W., Polymorphisms in manganese superoxide dismutase and catalase genes - functional study in Hong Kong Chinese asthma patients , Clinical and Experimental Allergy. 2006, 36: 440-447.

 

Mak J.C.W., Ho J.C.M., Ho S.P., Leung C.M., Law K.W., Lam W.K., Ip M.S.M. and Chan M.M.W., Polymorphisms in superoxide dismutase (SOD) and catalase genes - functional study in Chinese patients with asthma, Hong Kong Allergy Convention, Hong Kong. 2005, Abstract AB26: p.54.

 

Mak J.C.W. and Chan M.M.W., Reactive oxidant species in asthma. , Current Opinion in Pulmonary Medicine. 2006, 12(1): 7-11.

 

Mak J.C.W., Ho S.P., Wong M.P., Tsang K.W.T., Ip M.S.M., Lam W.K. and Chan M.M.W., Transforming growth factor (TGF)-b[sub]1[/sub] gene common polymorphisms and plasma TGF-b[sub]1[/sub] levels in patients with lung cancer, European Respiratory Journal. 2005, 26 (Suppl 49): 435S (#2797).

 

Mo H., Zeng G., Ren X., Li H., Ke C., Tan Y., Cai C., Lai K., Chen R., Chan M.M.W. and Zhong N., Longitudinal profile of antibodies against SARS-coronavirus in SARS patients and their clinical significance. , Respirology. 2006, 11(1): 49-53.

 

Wang J., Ho J.C.M., Lam W.K., Ip M.S.M., Chan M.M.W. and Tsang K.W.T., Lymphoepithelioma-like-carcinoma of the lung : experience with 13 cases, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2006, Abstract Book 104: pp. 59.

 

Researcher : Chan OO



List of Research Outputs

 

Chan O.O. and Lai K.C., A patient with long-standing iron-deficient anemia, Nature Clinical Practice. Gastroenterology & Hepatology. 2006, 3(2): 112-116.

 

Chan O.O. and Wong B.C.Y., Chemoprevention of colorectal cancer, Proceedings, 5th Shanghai International Conference of Gastroenterology, 7-9 July 2006, Shanghai, PR China. 2005, 126.

 

Chan O.O., Hui W.M., Chan C.K., Lai K.C., Hu H.C., Yuen R.M.F., Wong R.W.M., Lau G., Hui C.K., Lam S.K. and Wong B.C.Y., Colonoscopy Demand and Practice in a Regional Hospital over 9 Years in Hong Kong: Resource Implication for Cancer Screening, Gastroenterology. 2006, 130 (4 Suppl 2): A-618.

 

Chan O.O., Hui W.M., Chan C.K., Lai K.C., Hu H.C., Yuen R.M.F., Wong R.W.M., Lau G., Hui C.K., Lam S.K. and Wong B.C.Y., Colonoscopy demand and practice in a regional hospital over 9 years in Hong Kong: Resource implication for cancer screening, Digestion. 2006, 73(2-3): 84-88.

 

Chan O.O., Soliman A.S., Zhang Q., Rashid A., Bedeir A., Houlihan P.S., Mokhtar N., Al-Masri N., Ozbek U., Yaghan R., Kandilci A., Omar S., Kapran Y., Dizdaroglu F., Bondy M.L., Amos C.I., Issa J.P., Levin B. and Hamilton S.R., Differing DNA methylation patterns and gene mutation frequencies in colorectal carcinomas from Middle Eastern countries, Clinical Cancer Research. 2005, 11(23): 8281-8217.

 

Chan O.O., Cheng C., Hui W.M., Hu H.C., Wong Y.H., Lam K.F., Wong R.W.M., Lai K.C., Lam S.K. and Wong B.C.Y., Differing coping mechanisms, stress level and anorectal physiology in patients with functional constipation, World Journal of Gastroenterology. The WJG Press and Elsevier Inc., 2005, 11(34): 5362-5366.

 

Chan O.O., E-cadherin in gastric cancer, World Journal of Gastroenterology. 2006, 12(2): 199-203.

 

Chan O.O., Chu K.M., Lam S.K., Cheung K.L., Law S.Y.K., Kwok K.F., Wong R.W.M., Yuen R.M.F. and Wong B.C.Y., Early prediction of tumor recurrence after curative resection of gastric carcinoma by measuring soluble E-cadherin, Cancer. 2005, 104(4): 740-6.

 

Chan O.O., Peng J., Lam S.K., Lai K.C., Yuen R.M.F., Cheung K.L., Kwong Y.L., Rashid A., Chan C.K. and Wong B.C.Y., Eradication of Helicobacter pylori Infection Reverses E-cadherin Promoter Hypermethylation, Gut. 2006, 55: 463-468.

 

Chan O.O., Hui W.M., Hu H.C., Leung G., Chan C.K., Yuen R.M.F., Lam S.K. and Wong B.C.Y., Familial Aggregation in Constipated Subjects in a Tertiary Referral Center, Gastroenterology. 2006, 130 (4 Suppl 2): A-159.

 

Chan O.O. and Wong B.C.Y., General Mechanisms of Cancer. Edited by: Cho CH and Purohit V , In: Alcohol, Tobacco and Cancer. . Basel, Switzerland, Karger, 2006, 1-12.

 

Chan O.O., Chu K.M., Leung S.Y., Huang C., Sun Y.W., Ko S., Yuen R.M.F., Xia H.H.X., Cho C.H., Hui W.M., Lam S.K., Rashid A. and Wong B.C.Y., Helicobacter pylori infection, interleukin 1 beta polymorphism and predisposition to gastric cancer through the CpG island methylation pathway, Presented at 11th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong, 14 January 2006.

 

Chan O.O., Jim M.H., Lam K.F., Siu D.C.W., Tong S.M., Ng F.H., Hui W.M., Chan C.K., Lai K.C., Hu H.C., Yuen R.M.F., Lau Y.K., Lee S.W.L., Lam S.K. and Wong B.C.Y., Patients with Coronary Artery Disease are at High Risk for Developing Colorectal Cancer and Adenoma: An Interim Analysis of a Prospective Study, Gastroenterology. 2006, 130 (4 Supp 2): A-36.

 

Chan O.O., Hui W.M., Lam K.F., Leung G., Hu H.C., Chan C.K., Yuen R.M.F., Lam S.K. and Wong B.C.Y., The Clinical Characteristics of Patients with Idiopathic Constipation with a Positive Family History, Gastroenterology. 2006, 130 (4 Suppl 2): A-158.

 

Chan O.O., Chu K.M., Sun Y.W., Cheung H.K.L., Lam S.K., Yuen R.M.F., Hui W.M. and Wong B.C.Y., The association between interleukin 1 beta polymorphism and hypermethylation at tumor suppressor genes in gastric cancer. , Gastroenterology. 2005, 128 (Suppl 2): 1399-400.

 

Chan O.O., Lam K.F., Hui W.M., Hu W.H., Li J., Lai K.C., Chan C.K., Yuen R.M.F., Lam S.K. and Wong B.C.Y., Validated questionnaire on diagnosis and symptom severity for functional constipation in the Chinese population, Alimentary Pharmacology and Therapeutics. Blackwell Publishing Ltd, 2005, 22: 483-488.

 

Chan O.O., Chu K.M., Leung S.Y., Huang C., Sun Y., Ko S., Yuen R.M.F., Xia H.H.X., Cho C.H., Hui W.M., Lam S.K., Rashid A. and Wong B.C.Y., Helicobacter pylori Infection, Interleukin 1 Beta Polymorphism and Predisposition to Gastric Cancer Through the Cpg Island Methylation, Gastroenterology. 2006, 130 (4 Suppl 2): A-717.

 

Fan X.M., Jiang X., Gu Q., Ching Y.P., He H., Xia H.H.X., Lin M.C., Chan O.O., Yuen R.M.F., Kung H.F. and Wong B.C.Y., Inhibition of Akt/PKB by a COX-2 Inhibitor Induces Apoptosis in Gastric Cancer Cells, Digestion. 2006, 73(2-3): 75-83.

 

Fischbach W., Chan O.O. and Wong B.C.Y., Helicobacter pylori and gastric malignancy, Helicobacter. 2005, 10 Suppl 1: 34-39.

 

Gu Q., Xia H.H.X., Wang J., Wong R.W.M., Chan O.O., Lai K.C., Chan C.K., Yuen R.M.F., Fung F.M.Y., Wong K.W., Lam S.K. and Wong B.C.Y., Update on clarithromycin resistance in Helicobacter pylori in Hong Kong and its effect on clarithromycin-based triple therapy., Digestion. 2006, 72(2-3): 101-106.

 

Gu Q., Xia H.H.X., Wang J., Chan O.O., Lai K.C., Fung F.M.Y., Wong K.W., Cheung K.L., Kung H. and Wong B.C.Y., Update on clarithromycin resistance in Helicobacter pylori in Hong Kong and its effect on clarithromycin-based triple therapy., In: Gu Q, Xia HHX, Wang JD, Chan AOO, Lai KC, Chan CK, Yuen MF, Fung FMY, Wong KW, Cheung HKL, H.F. Kung HF, B.C.Y. Wong BCY.. , J Gastroenterol Hepatol . 2005, 20 (Suppl.): A160.

 

He H., Xia H.H.X., Wang J., Gu Q., Lin M.C., Zou B., Lam S.K., Chan O.O., Yuen R.M.F., Kung H.F. and Wong B.C.Y., Inhibition of human telomerase reverse transcriptase by nonsteroidal antiinflammatory drugs in colon carcinoma, Cancer. 2006, 106(6): 1243-9.

 

Lam C.M., Yong J.L., Chan O.O., Ng K.K.C., Poon R.T.P., Liu C.L., Lo C.M. and Fan S.T., Better survival in female patients with hepatocellular carcinoma: oral contraceptive pills related?, Journal of Clinical Gastroenterology. 2005, 39(6): 533-539.

 

Li G., Xia H.H.X., Chen M., Gu Q., Wang J., Peng J., Chan O.O., Cho C.H., So H.L., Lam S.K., Hu P.J., Liang Y.J., Lin H., Berg D.E., Feng Z.H., Langenback R. and Wong B.C.Y., Effects of Cyclooxygenase-1 and -2 Gene Disruption on Helicobacter pylori-Induced Inflammation, Journal of Infectious Diseases. 2006, 193(7): 1037-1046.

 

Tang L.P., Cho C.H., Hui W.M., Huang F.Y., Lai C.L., Xia H.H.X., Lam S.K., Rashid A., Wong B.C.Y. and Chan O.O., A negative correlation between IL-6 and DNA methylation in patients with gastric cancer, Supplement to Gastroenterology - Digestive Disease Week and the 107th Annual Meeting of the American Gastroenterological Association Institute, May 20-25, 2006, Los Angeles, CA. 2006, 130:4 Suppl 2: A-717.

 

Wang J., Peng Y., Sun Y., He H., Zhu S., An X.M., Li M., Lin M.C., Zou B., Xia H.H.X., Jiang B., Chan O.O., Yuen R.M.F., Kung H.F. and Wong B.C.Y., All-Trans Retinoic Acid Induces XAF1 Expression Through an Interferon Regulatory Factor-1 Element in Colon Cancer, Gastroenterology. 2006, 130(3): 747-758.

 

Wong B.C.Y., Chan O.O., Wong R.W.M., Hui W.M., Kung H. and Lam S.K., Attitudes and knowledge of colorectal cancer and screening in Hong Kong – A population-based study, Journal of Gastroenterology and Hepatology. 2006, 21(1 Pt 1): 41-46.

 

Xia B., Xia H.H.X., Ma C.W., Wong K.W., Fung F.M.Y., Hui C.K., Chan C.K., Chan O.O., Lai K.C., Yuen R.M.F. and Wong B.C.Y., Trends in the prevalence of peptic ulcer disease and Helicobacter pylori infection in family physician-referred uninvestigated dyspeptic patients in Hong Kong. , Alimentary Pharmacology and Therapeutics. 2005, 22(3): 243-9.

 

Xia H.H.X., He H., Wang J., Gu Q., Lin M.C., Zou B., Yu L., Sun Y., Chan O.O., Kung H.F. and Wong B.C.Y., Induction of apoptosis and cell cycle arrest by a specific c-Jun NH(2)-terminal kinase (JNK) inhibitor, SP-600125, in gastrointestinal cancers., Cancer Letters. 2005, 241(2): 268-74.

 

Xia H.H.X., Wong R.W.M., Chan O.O., Lam S.K., Lai K.C., Chan C.K., Cheung K.L., Fung F.M.Y., Wong K.W. and Wong B.C.Y., Natural acquisition of Helicobacter pylori in adult dyspeptic patients with or without previous infection – a 7-year follow-up study. Australian Gastroenterology Week 2005, 19 October 2005, Australia. , Journal of Gastroenterology and Hepatology. 2005, 20: Supp A112.

 

Yuen R.M.F., Tanaka Y., Ng I.O.L., Mizokami M., Yuen J.C.H., Wong D.K.H., Yuan H., Sum S.M., Chan O.O. and Lai C.L., Hepatic necroinflammation and fibrosis in patients with genotypes Ba and C, core-promoter and precore mutations, Journal of Viral Hepatitis . 2005, 12(5): 513-8.

 

Yuen R.M.F., Yuan H., Wong D.K.H., Yuen J.C.H., Wong R.W.M., Chan O.O., Wong B.C.Y., Lai K.C. and Lai C.L., Prognostic determinants for chronic hepatitis B in Asians: therapeutic implications. , Gut. 2005, 54(11): 1610-4.

 

Researcher : Chan OOA



List of Research Outputs

 

Lai K.C., Chu K.M., Hui W.M., Wong B.C.Y., Hu H.C., Wong W.M.R., Chan O.O.A., Wong J. and Lam S.K., Celecoxib compared with lansoprazole and naprosyn to prevent gastrointestinal ulcer complications, American Journal of Medicine. 2005, 118: 1271-1278.

 

Wong W.M.R., Gu Q., Chu K.M., Yee Y.K., Fung F.M.Y., Tong S.M., Chan O.O.A., Lai K.C., Chan C.K. and Wong B.C.Y., Lansoprazole, levofloxacin and amoxicillin triple therapy versus quadruple therapy as second-line treatment of resistant Helicobacter pylori infection, Alimentary Pharmacology & Therapeutics. 2006, 23: 421-427.

 

Researcher : Chan PS



List of Research Outputs

 

Chan P.S., Shen J., Fung P.C.W. and Cheung R.T.F., NPY acts on its Y1 receptor via Ca2+ as the second messenger to cause NO overproduction and mediate cell injury following oxygen and glucose deprivation in SK-N-MC cells, 11th Medical Research Conference, Medical Science Group. 2006, 81.

 

Researcher : Chan RHW



List of Research Outputs

 

Kwong Y.L., Lau W.C.S., Ho S.L., Epstein R., Young R.T.T., Chan H.H.L., Tse H.F., Lam L., Chen W.H., Lee K.L.F., Ip M.S.M., Tsang K.W.T., Lam B., Tang S.C.W., Chan R.H.W., Lee S.W.L., Tan K.C.B., Yeung C.K., Chan D.T.M., Wong R.W.S., Choy C.B.Y., Wong B.C.Y., Li F.K., Lo W.K., Lui S.L., Cheung R.T.F., Mak W., Ho J.C.M., Mok T.M.Y., Kung A.W.C., Cheung B.M.Y., Chow W.S., Yuen R.M.F. and Wat N.M.S., In: Lau CP, Kumana CR, Lai CL, Lai KN, Lam KSL, Lam WK, Problem-Based Medical Case Management. Hong Kong, Hong Kong University Press, 2005.

 

Lau E.O.Y., Tse H.F., Chan R.H.W., Chen W.H., Lee P.Y., Lee S.W.L., Chwang A.T.Y. and Lau C.P., Prediction of aortic augmentation index using radial pulse transmission-wave analysis, Journal of Hypertension. Lippincott Williams & Wilkins, 2006, 24(4): 723-730.

 

Yiu K.H., Siu C.W.D., Lee K.L.F., Lam L., Chan R.H.W., Lee S.W.L., Lau C.P. and Tse H.F., Adverse Clinical Outcomes in Left-sided Infective Endocarditis Complicated Intravenous drug addict, JACC . 2006, 47: 281A.

 

Yiu K.H., Siu C.W.D., Lee K.L.F., Lam L., Chan R.H.W., Lee S.W.L., Lau C.P. and Tse H.F., Temporal Trend of Infective Endocarditis in Chinese: A Population Based Study Over 10 Years Period, JACC. 2006, 984-24.

 

Researcher : Chan SHC



List of Research Outputs

 

Lo C.M., Cheung C.K.Y., Lau G., Yuen R.M.F., Liu C.L., Chan S.H.C., Fan S.T. and Wong J., Significance of hepatitis B virus genotype in liver transplantation for chronic hepatitis B, American Journal of Transplantation. Blackwell, 2005, 5: 1893-900.

 

Researcher : Chan TK



List of Research Outputs

 

Chan J.C.W., Chim J.C.S., Ooi C.G.C., Cheung B.M.Y., Liang R.H.S., Chan T.K. and Chan V.N.Y., Use of the oral chelator deferiprone in the treatment of iron overload in patients with Hb H disease, British Journal of Haematology. 2006, 133(2): 198-205.

 

Chan K., Sasanakul W., Mellars G., Chuansumrit A., Perry D., Lee C.A., Wong M.S., Chan T.K. and Chan V.N.Y., Detection Of Known Haemophilia B Mutations And Carrier Testing By Microarray., Thrombosis and Haemostasis.. 2005, 94: 872-878.

 

Chan V.N.Y., Ha S.Y., Au P., Lam C.C.K. and Chan T.K., A Chinese Family With Hemophilia B Leyden Due To T-->A Transition At Position +6 Of The FIX Gene, American Journal of Hematology. 2006, 81(4): 300-301.

 

Chan V.N.Y., Chan J.C.W., Chim J.C.S., Ooi C.G.C., Cheung B.M.Y., Liang R.H.S. and Chan T.K., Deferiprone in the treatment of iron overload in patients with Hb H disease, XXXth World Congress of the International Society of Hematology, Istanbul, Turkey. Istanbul, Turkey, 2005.

 

Cheng C.K., Chow L.W.C., Loo T.Y., Chan T.K. and Chan V.N.Y., The cell cycle checkpoint gene Rad9 is a novel oncogene activated by 11q13 amplification and DNA methylation in breast cancer, Cancer Research. 2005, 65: 8646-8654.

 

Researcher : Chan VNY



Project Title:

Localisation of the disease or disease-susceptibility gene for adolescent idiopathic scoliosis

Investigator(s):

Chan VNY, Chan K, Luk KDK, Cheng CK

Department:

Medicine

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

11/2003

 

Abstract:

To identify genes along the mouse chromosome 17 (which is in synteny to human chromosome 19p), that are expressed in tissues associated with AIS phenotype, such as muscle, bone, cartilage, tendon, etc; to identify by differential gene expression analysis those genes along human chromosome 19p13, expressed (differently- decreased or increased) in AIS patients compared to human control subjects; to sequence those genes of interest in genomic DNA of the indexed patients in the relevant AIS families, in order to identify the causative mutations.

 

Project Title:

Localisation of the disease or disease-susceptibility gene for adolescent idiopathic scoliosis

Investigator(s):

Chan VNY, Chan K, Lee SMY, Luk KDK

Department:

Medicine

Source(s) of Funding:

Merit Award for RGC CERG Funded Projects

Start Date:

11/2003

 

Abstract:

N/A

 

Project Title:

Epigenetic and genetic regulation of the AMIGO3 gene in carcinoma of the breast

Investigator(s):

Chan VNY, Chow LWC, Suen TK

Department:

Medicine

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

03/2006

 

Abstract:

We have identified in breast tumours several aberrantly methylated DNA fragments, one of which corresponds to the 5' flanking region of the amphoterin-induced gene and ORF3 (AMIGO3). It is a member of a novel family of transmembrane proteins containing six leucine rich repeats and one immunoglobulin-like domain [1]. We observed that AMIGO3 5' flanking region is frequently methylated in primary breast cancers (40.4%) and in 4 breast cancer cell lines. Furthermore, AMIGO3 5' flanking region methylation is associated with over-expression of mRNA and correlated positively with lymph node metastasis (p=0.037). The mechanism for this unexpected epigenetic or genetic effects required further elucidation. Recently another member of this family, AMIGO2 has been found to be associated with human gastric adenocarcinoma, with effects on ploidy, chromosomal stability, cell adhesion/migration and tumorigenicity [2]. A homophilic and heterophilic binding mechanism exists between the members of the AMIGO family. AMIGO expression can be induced by ligation of the Ig superfamily protein RAGE by amphoterin[1]. Since RAGE is known to play a role in tissue injury and in regulation of cell motility [3,4], it is possible that AMIGO3 plays a significant role in cancer cell metastasis. We hope to study the epigenetic and genetic regulation of AMIGO3 and explore its usefulness as a possible molecular marker in breast cancer. References:- [1] Kuja-Panula J, Kiiltomaki M, Yamashiro T, Rouhiainen A, Rauvala H. AMIGO, a transmembrane protein implicated in axon tract development, defines a novel protein family with leucine-rich repeats. J Cell Biol 2003; 160:963-973. [2] Rabenau KE, O'Toole JM, Bassi R, Kotanides H, Witte L, Ludwig DL, Pereira DS. DEGA/AMIGO-2, a leucine-rich repeat family member, differentially expressed in human gastric adenocarcinoma: effects on ploidy, chromosomal stability, cell adhesion/migration and tumorigenicity. Oncogene 2004; 23:5056-5067. [3] Rauvala H, Huttunen HJ, Fages C, Kaksonen M, Kinnunen T, Imai S, Raulo E, Kilpelainen I. Heparin-binding proteins HB-GAM (pleiotrophin) and amphoterin in the regulation of cell motility. Matrix Biol 2000; 19:377-387. [4] Schmidt AM, Yan SD, Yan SF, Stern DM. The biology of the receptor for advanced glycation end products and its ligands. Biochim Biophys Acta 2000;1498:99-111.

 

List of Research Outputs

 

Chan J.C.W., Chim J.C.S., Ooi C.G.C., Cheung B.M.Y., Liang R.H.S., Chan T.K. and Chan V.N.Y., Use of the oral chelator deferiprone in the treatment of iron overload in patients with Hb H disease, British Journal of Haematology. 2006, 133(2): 198-205.

 

Chan K., Sasanakul W., Mellars G., Chuansumrit A., Perry D., Lee C.A., Wong M.S., Chan T.K. and Chan V.N.Y., Detection Of Known Haemophilia B Mutations And Carrier Testing By Microarray., Thrombosis and Haemostasis.. 2005, 94: 872-878.

 

Chan V.N.Y., Invited Keynote Speaker "New Methods for Thalassaemia Diagnosis in the Embryo, the Foetus and the Adult", Hong Kong Institute of Medical Laboratory Sciences, Haematology Symposium on "New Developments in Diagnosis and Treatment of Thalassaemias and Haemoglobin Disorders", October. 2005.

 

Chan V.N.Y., Ha S.Y., Au P., Lam C.C.K. and Chan T.K., A Chinese Family With Hemophilia B Leyden Due To T-->A Transition At Position +6 Of The FIX Gene, American Journal of Hematology. 2006, 81(4): 300-301.

 

Chan V.N.Y., Chan J.C.W., Chim J.C.S., Ooi C.G.C., Cheung B.M.Y., Liang R.H.S. and Chan T.K., Deferiprone in the treatment of iron overload in patients with Hb H disease, XXXth World Congress of the International Society of Hematology, Istanbul, Turkey. Istanbul, Turkey, 2005.

 

Chan V.N.Y., Invited Speaker, "Preimplantation Genetic Diagnosis of Thalassemias", Annual Scientific Meeting of Hong Kong Institute of Medical Laboratory Sciences, Hong Kong, July. 2005.

 

Chan V.N.Y., Invited Speaker, Asian Network for Thalassemia Control Meeting, Bangkok, July. 2005.

 

Cheng C.K., Chow L.W.C., Loo T.Y., Chan T.K. and Chan V.N.Y., The cell cycle checkpoint gene Rad9 is a novel oncogene activated by 11q13 amplification and DNA methylation in breast cancer, Cancer Research. 2005, 65: 8646-8654.

 

Cheung C.L., Ng W.W., Lai M.H., Chan V.N.Y. and Kung A.W.C., Association of a single nucleotide polymorphism in low-density lipoprotein receptor-related protein 5 (LRP5) gene promoter region with peak bone mineral density: A case-control study, 27th Annual Meeting of the American Society for Bone & Mineral Research, 23-27 September 2005, Nashville, USA. 2005.

 

Gu J., Lai M.H., Chan V.N.Y. and Kung A.W.C., Association of estrogen receptor beta gene polymorphisms and rate of bone loss in perimenopausal women, 27th Annual Meeting of the American Society for Bone & Mineral Research, 23-27 September 2005, Nashville, USA. 2005.

 

Kung A.W.C., Lai M.H., Ng M.Y.M., Cheung W.M.W., Chan V.N.Y. and Sham P.C., Estrogen receptor beta polymorphisms predict risks of osteoporosis in men and women: A linkage and association study, 27th Annual Meeting of the American Society for Bone & Mineral Research, 23-27 September 2005, Nashville, USA. 2005.

 

Kung A.W.C., Lai M.H., Ng M.Y.M., Chan V.N.Y. and Sham P.C., T-1213C polymorphism of estrogen receptor beta is associated with low bone mineral density and osteoporotic fractures, Bone. 2006.

 

Kung A.W.C., Lau K.S., Cheung W.M.W. and Chan V.N.Y., Thyrotoxic periodic paralysis and polymorphisms of sodium-potassium ATPase genes, Clin Endocrinol (Oxf). 2006, 64: 158-61.

 

Lau H.L., Ng M.Y.M., Cheung W.M.W., Paterson A.D., Sham P.C., Luk K.D.K., Chan V.N.Y. and Kung A.W.C., Assessment of linkage and association of 13 genetic loci with bone mineral density, Journal of Bone and Mineral Metabolism. 2006, 24: 226-34.

 

Lau H.L., Ng M.Y.M., Jin L., Paterson A., Sham P.C., Luk K.D.K., Chan V.N.Y. and Kung A.W.C., Test of linkage and association of 14 genetic loci with bone size, 27th Annual Meeting of the American Society for Bone & Mineral Research, 23-27 September 2005, Nashville, USA. 2005.

 

Tse K.Y., Leung W.C., Leung K.Y., Lee C.P., Ng L.K.L., Lau E.T., Chan V.N.Y. and Tang M.H.Y., Full karyotyping, rapid aneuploidy diagnosis or both when invasive prenatal testing is performed for diagnosis of thalassaemia?, Molecular Human Reproduction. 2006, 12(1): 55-59.

 

Researcher : Chan WM



List of Research Outputs

 

Kung A.W.C., Chan W.M. and Lee K.K., Risk factors for hip fractures in Chinese postmenopausal women: a prospective study, The IOF World Congress on Osteoporosis, 2-6 June 2006, Toronto, Canada. 2006.

 

Researcher : Chan WWL



List of Research Outputs

 

Chim J.C.S., Chan W.W.L., Pang A.W.K. and Kwong Y.L., Preferential methylation of Wnt inhibitory factor-1 in acute promyelocytic leukemia: an independent poor prognostic factor, Leukemia. 2006, 20(5): 907-9.

 

Researcher : Chan YH



List of Research Outputs

 

Chan Y.H., Lau K.K., Li S.W., Shu X.O., Lau C.P. and Tse H.F., Lower level of phytoestrogen intake correlates with poorer vascular endothelial function in patients with high risk for cardiovascular events, European Heart Journal. 2006, 27: 291.

 

Researcher : Chan YY



List of Research Outputs

 

Leung A.Y.H., Leung J.C.K., Chan Y.Y., Ma E.S.K., Kwan T.F., Lai K.N., Meng A. and Liang R.H.S., Proliferating cell nuclear antigen (PCNA) as a proliferative marker during embryonic and adult zebrafish hematopoiesis, Histochemistry and Cell Biology. 2005, 124(2): 105-11.

 

Leung J.C.K., Chan Y.Y., Tang S.C.W., Chu K.M. and Lai K.N., Leptin induces TGF-b synthesis through functional leptin receptor expressed by human peritoneal meoshtelial cell, Kidney International. 2006, 69: 2078-2086.

 

Researcher : Chau MC



List of Research Outputs

 

Siu C.W.D., Jim M.H., Tse H.F., Fan K., Chau M.C. and Chow W.H., Comparison of the efficacy and safety profiles fo intravenuous vitamin K and fresh frozen plasma as treatment of warfarin-related over-anticoagulation in patients with mechanical heart valves, Am J Cardiol. 2006, 97(3): 409-11.

 

Researcher : Chen B



List of Research Outputs

 

Chen B., Lam K.S.L., Wang Y., Wu D., Lam C.W., Shen J., Wong L.C., Hoo R.L.C., Zhang J. and Xu A., Hypoxia dysregulates the production of adiponectin and plasminogen activator inhibitor-1 independent of reactive oxygen species in adipocytes, Biochem Biophys Res Commun. 2006, 341: 549-56.

 

Researcher : Chen J



List of Research Outputs

 

Liu B., Wang J., Chan K.M., Tjia W.M., Deng W., Guan X., Huang J.D., Li K.M., Chau P.Y., Chen D.J., Pei D., Pendas A.M., Cadinanos J., Lopez O.T.I.N. .C., Hutchison C., Chen J., Cao Y., Cheah K.S., Tryggvason K. and Zhou Z., Genomic instability in laminopathy-based permature aging., Nat Med 2005. 2005, 11(7): 780-5.

 

Researcher : Chen M



List of Research Outputs

 

Li G., Xia H.H.X., Chen M., Gu Q., Wang J., Peng J., Chan O.O., Cho C.H., So H.L., Lam S.K., Hu P.J., Liang Y.J., Lin H., Berg D.E., Feng Z.H., Langenback R. and Wong B.C.Y., Effects of Cyclooxygenase-1 and -2 Gene Disruption on Helicobacter pylori-Induced Inflammation, Journal of Infectious Diseases. 2006, 193(7): 1037-1046.

 

Researcher : Chen S



List of Research Outputs

 

Lai C.L., Chen S., Wong B.C.Y. and Yuen R.M.F., Gastroenterology and Hepatology., In: Lau CP, Chen MZ, Kumana CR, Lai CL, Lai KN, Lam KSL, Lam WK ed., Problem-Based Medical Cases Management. Hong Kong University Press, 2005, 75-107.

 

Researcher : Chen WH



Project Title:

Enoxaparin combined with epitfibatide or abciximab versus unfractionated heparin combined with epitfibatide or abciximab in percutaneous coronary intervention: obersvations on efficacy, safety, anticoagulation profile, and level of platelet inhibition

Investigator(s):

Chen WH, Lau CP

Department:

Medicine

Source(s) of Funding:

Other Funding Scheme

Start Date:

06/2001

 

Abstract:

To compare the safety, efficacy, anticoagulation profile and level of platelet inhibition in patients undergoing percutaneous coronary intervention using enoxaparin/eptifibatide, unfractionated heparin/epitfibatide, enoxaparin/abciximab, and unfractionated heparin/abciximab.

 

Project Title:

A prospective study to investigate the determinants of the quantity of embolized debris during native vessel percutaneous coronary intervention

Investigator(s):

Chen WH, Lau CP

Department:

Medicine

Source(s) of Funding:

Small Project Funding

Start Date:

11/2002

 

Abstract:

To identity the clinical and lesion characteristics that determine the quantity of embolized debris captured by a distal protection device during native vessel PCI.

 

Project Title:

A prospective study to evaluate the relation between aspirin resistance and the incidence and magnitude of myonecrosis after percutaneous coronary intervention

Investigator(s):

Chen WH, Lau CP

Department:

Medicine

Source(s) of Funding:

Small Project Funding

Start Date:

11/2003

 

Abstract:

To compare the incidence and magnitude of myoecrosis between aspirin-sensitive and -resistant patients undergoing PCI.

 

List of Research Outputs

 

Chen W.H., Kaul U., Leung S.K., Lau Y.K., Tan H.C., Leung A.W., Lee M.K., Li S.K., Ng W., Lee P.Y., Lam K.F., Tse H.F. and Lau C.P., A randomized, double-blind, placebo-controlled trial of abciximab for prevention of in-stent restenosis in diabetic patients after coronary stenting: results of the ASIAD (Abciximab in Stenting Inhibitis restenosis Among Diabetics) Trial, J Invasive Cardiol. 2005, 17(10): 534-8.

 

Chen W.H., Left anterior descending artery-to-right ventricle fistula and left ventricular free wall perforation after rotational atherectomy and stent implantation, In: Lee PY, Wang EP, J Invasive Cardiol.. 2005, 17(8): 450-1.

 

Kwong Y.L., Lau W.C.S., Ho S.L., Epstein R., Young R.T.T., Chan H.H.L., Tse H.F., Lam L., Chen W.H., Lee K.L.F., Ip M.S.M., Tsang K.W.T., Lam B., Tang S.C.W., Chan R.H.W., Lee S.W.L., Tan K.C.B., Yeung C.K., Chan D.T.M., Wong R.W.S., Choy C.B.Y., Wong B.C.Y., Li F.K., Lo W.K., Lui S.L., Cheung R.T.F., Mak W., Ho J.C.M., Mok T.M.Y., Kung A.W.C., Cheung B.M.Y., Chow W.S., Yuen R.M.F. and Wat N.M.S., In: Lau CP, Kumana CR, Lai CL, Lai KN, Lam KSL, Lam WK, Problem-Based Medical Case Management. Hong Kong, Hong Kong University Press, 2005.

 

Lau E.O.Y., Tse H.F., Chan R.H.W., Chen W.H., Lee P.Y., Lee S.W.L., Chwang A.T.Y. and Lau C.P., Prediction of aortic augmentation index using radial pulse transmission-wave analysis, Journal of Hypertension. Lippincott Williams & Wilkins, 2006, 24(4): 723-730.

 

Lee P.Y., Chen W.H., Ng W., Cheng X., Tse H.F., Lau C.P. and Kwong J.Y., Low-dose aspirin increase aspirin resistance in patients wtih coronary artery disease, Am J Med 2005. 2005, 118: 723-7.

 

Ng W., Wong R.W.M., Chen W.H., Tse H.F., Lee P.Y., Lai K.C., Li L.S.W., Ng M.M.T., Lam K.F., Cheng X. and Lau C.P., Incidence and predictors of upper gastrointestinal bleeding in patients receiving low-dose aspirin for secondary prevention of cardiovascular events in patients with coronary artery disease, World Journal of Gastroenterology. Beijing, China, The WJG Press, 2006, 12(18): 2923-2927.

 

Researcher : Chen X



List of Research Outputs

 

Zhang H., Jin Y., Chen X., Jin C., Law S.Y.K., Tsao G.S.W. and Kwong Y.L., Cytogenetic aberrations in immortalization of esophageal epithelial cells, Cancer Genetics and Cytogenetics. 2006, 165(1): 25-35.

 

Zhong Q., Leung J.C.K., Chan L.Y., Tsang W.L., Chen X. and Lai K.N., The study of Chinese medicinal herbal formula Shen San Fang in the treatment of experimental IgA nephropathy, the American Journal Of Chinese Medicine. 2005, 33(4): 613-626.

 

Researcher : Chen X



List of Research Outputs

 

Zhang H., Jin Y., Chen X., Jin C., Law S.Y.K., Tsao G.S.W. and Kwong Y.L., Cytogenetic aberrations in immortalization of esophageal epithelial cells, Cancer Genetics and Cytogenetics. 2006, 165(1): 25-35.

 

Zhong Q., Leung J.C.K., Chan L.Y., Tsang W.L., Chen X. and Lai K.N., The study of Chinese medicinal herbal formula Shen San Fang in the treatment of experimental IgA nephropathy, the American Journal Of Chinese Medicine. 2005, 33(4): 613-626.

 

Researcher : Cheng C



Project Title:

Cultural differences in adaptation to the changing environment: A cultural-moderational model of coping flexibility

Investigator(s):

Cheng C, Tong YY

Department:

Psychology

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

01/2005

 

Abstract:

To expand the scope of the current conceptualization of coping flexibility from an intra-personal to an interpersonal perspective; to formulate a new conceptual model to explicate cultural differences in coping flexibility and why such cultural differences exist; to develop and validate the various constructs of the proposed model; to adopt a multimethod approach for testing the assumptions and hypotheses of the new model with sophisticated methods.

 

List of Research Outputs

 

Researcher : Cheng CK



Project Title:

Epigenetic and genetic regulation of the cell cycle checkpoint protein Rad9 in breast cancer

Investigator(s):

Cheng CK, Chan VNY, Chow LWC

Department:

Medicine

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

Completion Date:

04/2006

 

Abstract:

To explore the potential usefulness of Rad9 as a molecular marker for breast cancer.

 

List of Research Outputs

 

Cheng C.K., Chow L.W.C., Loo T.Y., Chan T.K. and Chan V.N.Y., The cell cycle checkpoint gene Rad9 is a novel oncogene activated by 11q13 amplification and DNA methylation in breast cancer, Cancer Research. 2005, 65: 8646-8654.

 

Researcher : Cheng KY



List of Research Outputs

 

Cheng K.Y., Lam K.S.L. and Xu A., Receptor and postreceptor signalling pathways that mediate adiponectin-induced Akt activation in endothelial cells, 11th Medical Research Conference, HKU, Jan 2006.

 

Researcher : Cheng SW



List of Research Outputs

 

Lui S.L., Cheng S.W., Ng F.S.K., Ng S.Y., Wan K.M., Yip T., Tse K.C., Lam M.F., Lai K.N. and Lo W.K., Cefazolin plus netilmicin versus cefazolin plus ceftazidime for treating CAPD peritonitis: effect on residual renal function, Kidney International. 2005, 68(5): 2375-2380.

 

Researcher : Cheng X



List of Research Outputs

 

Lee P.Y., Chen W.H., Ng W., Cheng X., Tse H.F., Lau C.P. and Kwong J.Y., Low-dose aspirin increase aspirin resistance in patients wtih coronary artery disease, Am J Med 2005. 2005, 118: 723-7.

 

Ng W., Wong R.W.M., Chen W.H., Tse H.F., Lee P.Y., Lai K.C., Li L.S.W., Ng M.M.T., Lam K.F., Cheng X. and Lau C.P., Incidence and predictors of upper gastrointestinal bleeding in patients receiving low-dose aspirin for secondary prevention of cardiovascular events in patients with coronary artery disease, World Journal of Gastroenterology. Beijing, China, The WJG Press, 2006, 12(18): 2923-2927.

 

Researcher : Cheng X



List of Research Outputs

 

Lee P.Y., Chen W.H., Ng W., Cheng X., Tse H.F., Lau C.P. and Kwong J.Y., Low-dose aspirin increase aspirin resistance in patients wtih coronary artery disease, Am J Med 2005. 2005, 118: 723-7.

 

Ng W., Wong R.W.M., Chen W.H., Tse H.F., Lee P.Y., Lai K.C., Li L.S.W., Ng M.M.T., Lam K.F., Cheng X. and Lau C.P., Incidence and predictors of upper gastrointestinal bleeding in patients receiving low-dose aspirin for secondary prevention of cardiovascular events in patients with coronary artery disease, World Journal of Gastroenterology. Beijing, China, The WJG Press, 2006, 12(18): 2923-2927.

 

Researcher : Cheung AHK



List of Research Outputs

 

Chan M.M.W., Chan F.H.W., Cheung A.H.K., Dai D.L., Chu L.W., Lam W.K., Leung C.C., Kam K.M. and Tam C.M., Prevalence of tuberculous infection and active tuberculosis in old age homes in Hong Kong., Journal of the American Geriatrics Society. 2006, 54: 1334-40.

 

Mak J.C.W., Leung C.M., Ho S.P., Ko F.W.S., Cheung A.H.K., Ip M.S.M. and Chan M.M.W., Polymorphisms in manganese superoxide dismutase and catalase genes - functional study in Hong Kong Chinese asthma patients , Clinical and Experimental Allergy. 2006, 36: 440-447.

 

Researcher : Cheung BMY



Project Title:

A gene locus for hypertension and obesity on chromosome 17

Investigator(s):

Cheung BMY

Department:

Medicine

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

Completion Date:

10/2005

 

Abstract:

To identify single nucleotide Polymorphisms in the 17p12 region of chromosome 17 associated with hypertension and obesity; to assess their functional significance in relation to blood pressure, obesity and relevant metabolic and hormonal variables.

 

Project Title:

Detection of human body temperature with infrared thermographic imaging: accuracy and feasibility in detection of fever in human subjects

Investigator(s):

Cheung BMY, Chan LS, Kumana CR

Department:

Medicine

Source(s) of Funding:

Research Fund for the Control of Infectious Diseases - Full Grants

Start Date:

09/2005

 

Abstract:

The study will provide crucially needed information for the refinement and optimization of the application of the infrared thermography (IRT) technique as a fever screening mechanism.

 

List of Research Outputs

 

Ansari M.T., Cheung B.M.Y. and Karlberg J.P.E., Prolonged Seated Immobility-associated Venous Coagulability in a Factor V Leiden Heterozygote:a Case-comparative Study, Blood Coagulation and Fibrinolysis. 2006, 17: 187-191.

 

Chan J.C.W., Chim J.C.S., Ooi C.G.C., Cheung B.M.Y., Liang R.H.S., Chan T.K. and Chan V.N.Y., Use of the oral chelator deferiprone in the treatment of iron overload in patients with Hb H disease, British Journal of Haematology. 2006, 133(2): 198-205.

 

Chan V.N.Y., Chan J.C.W., Chim J.C.S., Ooi C.G.C., Cheung B.M.Y., Liang R.H.S. and Chan T.K., Deferiprone in the treatment of iron overload in patients with Hb H disease, XXXth World Congress of the International Society of Hematology, Istanbul, Turkey. Istanbul, Turkey, 2005.

 

Cheung B.M.Y., Manil Y.B., Tse H.F., Kumana C.R. and Lau C.P., Advantages of blood pressure optimization, Adv Ther. 2005, 22(4): 285-96.

 

Cheung B.M.Y., Leung R.Y.H., Man Y.B., Ong K.L., Wong L.Y.F., Lau C.P. and Lam K.S.L., Association of hypertension with single nucleotide polymorphisms in the quantitative trait locus for abdominal obesity-metabolic syndrome on chromosome 17, J Hum Hyperten. 2006.

 

Cheung B.M.Y., Wong Y.L. and Lau C.P., British Journal of Clinical Pharmacology, Queen Mary Utilisation of Antihypertensive Drugs Study: Use of Antihypertensive Drug Classes in the Hypertension Clinic 1996-2004. 2005, 30: 391-399.

 

Cheung B.M.Y., Chau J., McGhee S.M., Lauder I.J., Lau C.P. and Kumana C.R., Cost-effectiveness of Statins for Coronary Heart Disease Patients with Hypercholesterolaemia, Hong Kong Medical Journal. China, Scientific Communications International, Ltd., 2006, 12(2) Supplement: 20-23.

 

Cheung B.M.Y., Cheung G.T.Y., Lauder I.J., Lau C.P. and Kumana C.R., Meta-analysis of Large Outcome Trials of Angiotensin Receptor Blockers in Hypertension, Journal of Human Hypertension. 2006, 20(1): 37-43.

 

Cheung B.M.Y., Outstanding Teacher Award, University of Hong Kong School of Professional and Continuing Education. 2006.

 

Cheung B.M.Y., Ong K.L., Man Y.B., Lam K.S.L. and Lau C.P., Prevalence, Awareness, Treatment, and Control of Hypertension: United States National Health and Nutrition Examination Survey 2001-2, Journal of Clinical Hypertension. United States, Elsevier, 2006, 8: 93-98.

 

Cheung B.M.Y., Lo J.L., Fong H.Y., Chan M.Y., Wong S.H., Wong C.M., Lam K.S.L., Lau C.P. and Karlberg J.P.E., Randomised controlled trial of qigong in the treatment of mild essential hypertension, J Hum Hypertens. 2005, 19: 697-704.

 

Cheung B.M.Y., The Metabolic Syndrome in China , British Journal of Clinical Pharmacology. England, Blackwell Scientific Publications, 2006, (In press): (In press).

 

Cheung B.M.Y., The New Cardiovascular Continuum, Hong Kong Medical Journal. Hong Kong, 2006, 12(2): 161-163.

 

Cheung B.M.Y., The Therapeutic Potential of Angiotensin Receptor Blockers for Hypertension, Expert Opinion on Investigational Drugs. England, Ashley Publications Ltd., 2006, 15(6): 625-635.

 

Hung I.F.N., Wu A.K.L., Cheng V.C.C., Tang S.F., To K.K.W., Yeung C.K., Woo P.C.Y., Lau S.K.P., Cheung B.M.Y. and Yuen K.Y., Fatal interaction between clarithromycin and colchicine in patients with renal insufficiency: a retrospective study., Clinical infectious diseases. 2005, 41(3): 291-300.

 

Kumana C.R., Cheung B.M.Y., Cheung G.T.Y., Ovedal T. and Pederson B., Rhythm vs rate control of atrial fibrillation meta-analysed by number needed to treat., Br J clin Pharmacol. 2005, 60(4): 347-54.

 

Kwong Y.L., Lau W.C.S., Ho S.L., Epstein R., Young R.T.T., Chan H.H.L., Tse H.F., Lam L., Chen W.H., Lee K.L.F., Ip M.S.M., Tsang K.W.T., Lam B., Tang S.C.W., Chan R.H.W., Lee S.W.L., Tan K.C.B., Yeung C.K., Chan D.T.M., Wong R.W.S., Choy C.B.Y., Wong B.C.Y., Li F.K., Lo W.K., Lui S.L., Cheung R.T.F., Mak W., Ho J.C.M., Mok T.M.Y., Kung A.W.C., Cheung B.M.Y., Chow W.S., Yuen R.M.F. and Wat N.M.S., In: Lau CP, Kumana CR, Lai CL, Lai KN, Lam KSL, Lam WK, Problem-Based Medical Case Management. Hong Kong, Hong Kong University Press, 2005.

 

Li Y., Leung W.C.W., Chen Y., Cheung B.M.Y., Liang R.Y.H., Yik P.Y., Hui K.C., Ng P.K.M., Mak W.W., Jin D. and Song Y., Association of the cholesterol 24S-hydroxylase polymorphism with Alzheimer's disease in Chinese, HUGO 2006 Helsinki, Finland, 31 May-03 June 2006 . 2006.

 

Li Y., Leung W.C.W., Chen Y., Cheung B.M.Y., Liang R.Y.H., Yik P.Y., Ng K.M., Mak W., Jin D., st. George-Hyslop P. and Song Y., Intron 2 (T/C) CYP46 polymorphism is associated with Alzheimer's disease in Chinese. , Dement Geriatr Cogn Disord. 2006, 22: 399-404.

 

Li Y.Y., Cheung B.M.Y., Wong L.Y.F., Hwang I.S.S., Kumana C.R. and Tang F., Adrenomedullin gene expression and levels in the cardiovascular system after treatment with lipopolysaccharide, Neuropeptides. 2005, 39: 73-80.

 

Li Y.Y., Wong L.Y.F., Cheung B.M.Y., Hwang I.S.S. and Tang F., Differential Induction of Adrenomedullin, Interleukins and Tumour Necrosis Factor-aby Lipopolysaccharide in Rat Tissues in Vivo, Clinical and Experimental Pharmacology and Physiology. Australia, Blackwell Science Asia, 2005, 32(12): 1110-1118.

 

Li Y.Y., Wong L.Y.F., Cheung B.M.Y., Hwang I.S.S. and Tang F., Differential induction of adrenomedullin, interleukins and tumour necrosis factor-alpha by lipopolysaccharide in rat tissues in vivo. , Clinical and Experimental Pharmacology and Physiology. 2005, 32: 1110-1118.

 

McGhee S.M., Lam C.L.K., Lam T.P., Cheung B.M.Y., Schooling C.M. and McInnes G.T., An investigation into the current management of hypertension in Hong Kong: A two-phase study (Research dissemination report), Hong Kong Medical Journal. 2006, 12(2) Suppl 1: 24-27.

 

Thomas G.N., Schooling C.M., McGhee S.M., Ho D.S.Y., Cheung B.M.Y., Wat N.M.S., Janus E.D., Lam K.S.L. and Lam T.H., Smoking effect modification on all-cause and vascular mortality associated with the metabolic syndrome: The Hong Kong cardiovascular risk factor study (abstract), 4th Annual Conference of the International Society for the Prevention of Tobacco Induced Disease, 30 September - 2 October 2005, Athens, Greece. Athens, Greece, Int'l Society for the Prevention of Tobacco Induced Disease, 2005.

 

Researcher : Cheung CL



List of Research Outputs

 

Cheung C.L., Ng W.W., Lai M.H., Chan V.N.Y. and Kung A.W.C., Association of a single nucleotide polymorphism in low-density lipoprotein receptor-related protein 5 (LRP5) gene promoter region with peak bone mineral density: A case-control study, 27th Annual Meeting of the American Society for Bone & Mineral Research, 23-27 September 2005, Nashville, USA. 2005.

 

Researcher : Cheung GTY



List of Research Outputs

 

Cheung B.M.Y., Cheung G.T.Y., Lauder I.J., Lau C.P. and Kumana C.R., Meta-analysis of Large Outcome Trials of Angiotensin Receptor Blockers in Hypertension, Journal of Human Hypertension. 2006, 20(1): 37-43.

 

Kumana C.R., Cheung B.M.Y., Cheung G.T.Y., Ovedal T. and Pederson B., Rhythm vs rate control of atrial fibrillation meta-analysed by number needed to treat., Br J clin Pharmacol. 2005, 60(4): 347-54.

 

Researcher : Cheung KF



List of Research Outputs

 

Lu L., Hui C.K., Zhang H., Yueng Y.H., Cheung K.F. and Lau G., Quantification and Correlation of HBV DNA and RNA inPeripheral Blood Mononuclear Cells adn HBV DNA in Serum in Chronic Hepatitis B, J Gastroenterol and Hepatol. 2006, 21(2): A77.

 

Researcher : Cheung KL



List of Research Outputs

 

Chan O.O., Chu K.M., Lam S.K., Cheung K.L., Law S.Y.K., Kwok K.F., Wong R.W.M., Yuen R.M.F. and Wong B.C.Y., Early prediction of tumor recurrence after curative resection of gastric carcinoma by measuring soluble E-cadherin, Cancer. 2005, 104(4): 740-6.

 

Chan O.O., Peng J., Lam S.K., Lai K.C., Yuen R.M.F., Cheung K.L., Kwong Y.L., Rashid A., Chan C.K. and Wong B.C.Y., Eradication of Helicobacter pylori Infection Reverses E-cadherin Promoter Hypermethylation, Gut. 2006, 55: 463-468.

 

Gu Q., Xia H.H.X., Wang J., Chan O.O., Lai K.C., Fung F.M.Y., Wong K.W., Cheung K.L., Kung H. and Wong B.C.Y., Update on clarithromycin resistance in Helicobacter pylori in Hong Kong and its effect on clarithromycin-based triple therapy., In: Gu Q, Xia HHX, Wang JD, Chan AOO, Lai KC, Chan CK, Yuen MF, Fung FMY, Wong KW, Cheung HKL, H.F. Kung HF, B.C.Y. Wong BCY. , J Gastroenterol Hepatol . 2005, 20 (Suppl.): A160.

 

Xia H.H.X., Wong R.W.M., Chan O.O., Lam S.K., Lai K.C., Chan C.K., Cheung K.L., Fung F.M.Y., Wong K.W. and Wong B.C.Y., Natural acquisition of Helicobacter pylori in adult dyspeptic patients with or without previous infection – a 7-year follow-up study. Australian Gastroenterology Week 2005, 19 October 2005, Australia. , Journal of Gastroenterology and Hepatology. 2005, 20: Supp A112.

 

Researcher : Cheung RTF



Project Title:

Cognitive impairment and dementia among stroke patients in Hong Kong

Investigator(s):

Cheung RTF

Department:

Medicine

Source(s) of Funding:

Small Project Funding

Start Date:

11/2003

Completion Date:

10/2005

 

Abstract:

To study: (1) the prevalence and risk factors of vascular cognitive impairment and dementia in Chinese stroke patients and (2) the incidence and risk factors of vascular cognitive impairment and dementia upon follow up of Chinese stroke patients without dementia during initial assessment.

 

Project Title:

Use of functional magnetic resonance imaging to predict benefits of acupuncture for stroke patients with persistent motor or language deficits

Investigator(s):

Cheung RTF, Li LSW, Yang ES, Leung KP, Li G, Au Yeung K.M.

Department:

Medicine

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

10/2004

 

Abstract:

To use functional magnetic resonance imaging (MRI) to identify stroke patients with or without activations of brain sites relevant to their persistent arm paralysis or language impairment during stimulation of the deficit-implicated acupoints and then apply randomized, double-blinded, acupoint-controlled clinical trials to confirm the benefits of acupuncture in post-stroke rehabilitation of the deficit. The results will confirm the value of functional MRI in identifying responders to acupuncture in post-stroke motor or language rehabilitation and reveal the benefit of acupuncture treatment over certain disease-implicated acupoints.

 

Project Title:

Role of ischemia in Alzheimer's disease - an experimental study in transgenic mice

Investigator(s):

Cheung RTF

Department:

Medicine

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

 

Abstract:

To study (1) the influence of genotype on the cerebral blood flow and infarct volume of transgenic mice overexpressing amyloid precursor protein (APP) alone or with human mutant presenilin-1 (PS-1) gene following photothrombotic stroke, and to study (2) the effects of photothrombotic stroke on the sensorimotor functions and visuospatial memory in the APP transgenic mice and APP/PS-1 double transgenic mice.

 

Project Title:

Use of functional magnetic resonance imaging to predict benefits of acupuncture for stroke patients with persistent motor or language deficits

Investigator(s):

Cheung RTF

Department:

Medicine

Source(s) of Funding:

Merit Award for RGC CERG Funded Projects

Start Date:

01/2005

 

Abstract:

N/A

 

Project Title:

Development of Chinese-language versions of internationally-accepted stroke training materials for healthcare professionals treating Chinese stroke patients

Investigator(s):

Cheung RTF, Lyden PD, Jackson CM, Tsoi T.H.

Department:

Medicine

Source(s) of Funding:

S.K. Yee Medical Foundation - General Award

Start Date:

04/2005

 

Abstract:

To develop Chinese-language versions of internationally-accepted stroke training materials, and to make them available to healthcare professionals treating Chinese stroke patients.

 

Project Title:

Effects of neuropeptide Y-Y1 and Y2 receptor activation or inhibition on free radical generation and intracellular calcium concentration

Investigator(s):

Cheung RTF

Department:

Medicine

Source(s) of Funding:

Small Project Funding

Start Date:

12/2005

 

Abstract:

Purpose (1) To study the effects of neuropeptide Y (NPY) and its Y1 or Y2 agonists and antagonists on generation of nitric oxide (NO) and superoxide anion as well as intracellular calcium ion concentration in in vivo and in vitro stroke models (2) To study the interactions of NPY and its Y1 or Y2 agonists and antagonists with inhibitors of NO synthase or NO donor in in vivo and in vitro stroke models Key Issues There is evidence that NPY mediates ischemic damage via its Y1 receptors during focal cerebral ischemia and that inhibition of the Y1 receptors may confer neuroprotection against ischemic injury. The underlying mechanisms are unknown, and preliminary information suggests that the opposite actions of NPY on neuronal and endothelial NO synthase may be relevant. According to the literature, generation of free radicals, such as NO and superoxide anion, mediates ischemic injury. Elevation of intracellular calicum concentration also lead to ischemic damage via activation of intracellular enzymes, including neuronal NOS. On the other hand, activation of endothelial NOS maintains microcirculation and lessens the ischemic injury. Problems being addressed (1) Ability of NPY Y1 or Y2 agonist/antagonist to attenuate/augment ischemia-stimulated increase in brain levels of NO and superoxide anion (2) Ability of NPY Y1 or Y2 agonist/antagonist to attenuate/augment ischemia-stimulated rise in intracellular calcium ion concentration (3) Interactions between NPY Y1 or Y2 agonist/antagonist and NO donor or NO synthase inhibitor in stroke models

 

List of Research Outputs

 

Chan K.H., Mak W., Cheung R.T.F., Cheng T.S. and Ho S.L., Muscle-specific kinase autoantibody in acetylcholine receptor antibody-negative generalized acquired myasthenia gravis, 11th Medical Research Conference, Medical Science Group. 2006, 80.

 

Chan P.S., Shen J., Fung P.C.W. and Cheung R.T.F., NPY acts on its Y1 receptor via Ca2+ as the second messenger to cause NO overproduction and mediate cell injury following oxygen and glucose deprivation in SK-N-MC cells, 11th Medical Research Conference, Medical Science Group. 2006, 81.

 

Cheung R.T.F., A Review of Reversible Dementia, Symposium on Neurodegenerative Disorders, Hong Kong Medical Forum 2005. 2005.

 

Cheung R.T.F., A review of reversible dementia, 10th Hong Kong Medical Forum. 2005, 21.

 

Cheung R.T.F., Case Presentation From QMH, Interactive Case Presentation, Quarterly Scientific Meeting 2005, Hong Kong Stroke Society. 2005.

 

Cheung R.T.F., Comment on Guillain Barre Syndrome, and comment on spinal epidural abscess, 簡介格巴二氏綜合症和脊髓硬膜外膿腫, 腦有所醫:二十二個為「腦」力而加油的感人故事, ET Press, 2006, 179-180.

 

Cheung R.T.F., Comment on relationships between cardiac diseases and stroke, and comment on infective endocarditis, 簡介心臟病和中風的關係、感染性心內膜炎症, 腦有所醫:二十二個為「腦」力而加油的感人故事, ET Press, 2006, 83-85.

 

Cheung R.T.F., Comment on stroke, 簡介中風症, 腦有所醫:二十二個為「腦」力而加油的感人故事, ET Press, 2006, 189-191.

 

Cheung R.T.F., Editorial, 編者的話, 腦有所醫:二十二個為「腦」力而加油的感人故事, ET Press, 2006, 11-12.

 

Cheung R.T.F., Migraine Assessment for Prophylaxis (MAP) in Hong Kong: a Multicentre Study, Hong Kong Medical Journal. 2005, 11: 18.

 

Cheung R.T.F., Official Chinese translation for Slide-Kit 2003/2004 of EUSI Recommendations, EUSI Website. 2005.

 

Cheung R.T.F., Sir David Todd Lecture: Functional CT and MRI studies in stroke, Annual Scientific Meeting, Hong Kong College of Physicians, Synapse. 2005, 22-23.

 

Cheung R.T.F., Sir David Todd Lectureship, Hong Kong College of Physicians. 2005.

 

Cheung R.T.F., Stroke Management – The Latest Version, Public Lecture Series, Hong Kong Neurological Society, St. James’s Settlement. 2005.

 

Cheung R.T.F., Use of functional MRI to evaluate response to acupuncture, 4th World Congress for NeuroRehabilitation. 2006, 20: 82-83.

 

Cheung R.T.F., Use of functional magnetic resonance imaging in stroke treatment, Cerebrovascular and Cardiovascular Diseases – Integrating Chinese and Western Medicine Scientific Seminar. 2006, 305.

 

Cheung R.T.F., Chan H.M., Tsoi T.H., Ng P.W., Ng K.K. and Yeung H.M., 腦有所醫:二十二個為「腦」力而加油的感人故事, 2006, 1-216.

 

Fong C.Y.G., Cheng T.S., Lam K., Cheng W.K., Mok B.K.Y., Cheung C.M., Chim J.C.S., Mak W., Chan K.H., Tsang K.L., Kwan M.C., Tsoi T.H., Cheung R.T.F. and Ho S.L., An epidemiological study of motor neuron disease in Hong Kong, Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. 168, 2005, 6: 164.

 

Ji J., So R.H.Y., Lor F., Cheung R.T.F., Howarth P. and Stanney K., A search for possible neural pathways leading to visually induced motion sickness, Vision. 2005, 17: 131-134.

 

Kay R. and Cheung R.T.F., Comment on spinocerebellar ataxias, 簡介小腦萎縮症, 腦有所醫:二十二個為「腦」力而加油的感人故事, 2006, 105.

 

Kwong Y.L., Lau W.C.S., Ho S.L., Epstein R., Young R.T.T., Chan H.H.L., Tse H.F., Lam L., Chen W.H., Lee K.L.F., Ip M.S.M., Tsang K.W.T., Lam B., Tang S.C.W., Chan R.H.W., Lee S.W.L., Tan K.C.B., Yeung C.K., Chan D.T.M., Wong R.W.S., Choy C.B.Y., Wong B.C.Y., Li F.K., Lo W.K., Lui S.L., Cheung R.T.F., Mak W., Ho J.C.M., Mok T.M.Y., Kung A.W.C., Cheung B.M.Y., Chow W.S., Yuen R.M.F. and Wat N.M.S., In: Lau CP, Kumana CR, Lai CL, Lai KN, Lam KSL, Lam WK, Problem-Based Medical Case Management. Hong Kong, Hong Kong University Press, 2005.

 

Lee T.M.C., Zhang J.X., Chan C.H., Yuen S.L., Chu L.W., Cheung R.T.F., Chan Y.S., Fox P.T. and Gao J.H., Age-related differences in response regulation as revealed by functional MRI, Brain Research. 2006, 1076(1): 171-176.

 

Li G., Cheung R.T.F., Gao J.H., Lee T.M.C., Tan L.H., Fox P., Jack Jr C.R. and Yang E.S., Cognitive Processing In Chinese Literate And Illiterate Subjects: An fMRI Study , In: Peter Fox, Hum Brain Mapp . 2005, 27: 144-152.

 

Luk J.K.H., Cheung R.T.F., Ho S.L. and Li L.S.W., Does age predict outcome in stroke rehabilitation? A study of 878 Chinese subjects, 4th World Congress for NeuroRehabilitation. 2006, 20: 174.

 

Luk J.K.H., Cheung R.T.F., Ho S.L. and Li L.S.W., Does age predict outcome in stroke rehabilitation? A study of 878 Chinese subjects, Cerebrovascular Diseases. 2006, 21: 229-234.

 

Mak W., Cheng T.S., Chan K.H., Cheung R.T.F. and Ho S.L., A possible explanation for the racial difference in distribution of large-arterial cerebrovascular disease: Ancestral European settlers evolved genetic resistance to atherosclerosis, but confined to the intracranial arteries, Medical Hypotheses. 2005, 65: 637-648.

 

Mak W., Kwan M.W., Cheng T.S., Chan K.H., Cheung R.T.F. and Ho S.L., Cerebrospinal fluid to serum glucose ratio in non-hypoglycorrhachic conditions, Hong Kong Medical Journal. 2005, 11: 457-462.

 

Mak W., Kwan M.W.M., Cheng T.S., Chan K.H., Cheung R.T.F. and Ho S.L., Myopia as a latent phenotype of a pleiotropic gene positively selected for facilitating neurocognitive development, and the effects of environmental factors in its expression, Medical Hypotheses. 2006, 6: 1209-1215.

 

Ravishankar K., Siow C., Wang S.J., Chung C.S., Cheung R.T.F., Chankrachang R., Merican J.S. and Sakai F., Asian Headache Foundation (AHF) – launch of a new headache organization, Cephalagia. 2005, 25: 983.

 

Shen J., Ma S.K.Y., Chan P., Lee W., Fung P.C.W., Cheung R.T.F., Tong Y. and Liu K.J., Nitric oxide down-regulates caveolin-1 expression in rat brains during focal cerebral ischemia and reperfusion injury, Journal of Neurochemistry. 2006, 96(4): 1078-89.

 

Wang S.J., Chankrachang S., Siow C., Chung C.S., Cheung R.T.F., Ravishankar K., Merican J.S. and Sakai F., Migraine disability awareness campaign in Asia: Migraine Assessment for Prophylaxis (MAP), Cephalalgia. 2005, 25: 974.

 

Researcher : Cheung WC



List of Research Outputs

 

Au W.Y., Cheung W.C., Hu H.C., Chan G.C.F., Ha S.Y., Khong P.L., Ma E.S.K. and Liang R.H.S., Hyperbilirubinaemia and cholelithiasis in Chinese patients with hemoglobin H disease., Annals of Hematology. 2005, 84(10): 671-674.

 

Researcher : Cheung WMW



Project Title:

Setting up in vitro model systems for studying the functional roles of nuclear receptor PPARgamma during osteoblastogenesis

Investigator(s):

Cheung WMW, Kung AWC

Department:

Medicine

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

09/2004

Completion Date:

10/2005

 

Abstract:

To identify the correlation between expression level of PPARγ and the stages of osteoblastogenesis; to set up in vitro cell models for studying the functional role(s) of PPARγ during osteoblastogenesis; to identify the effect of PPARγ blockage on the induction of osteoblastogenesis in mesenchymal stem cells.

 

Project Title:

Probing the functions of PPAR-gamma during osteoblastogenic differentiation

Investigator(s):

Cheung WMW

Department:

Medicine

Source(s) of Funding:

Incentive Award for RGC CERG Fundable But Not Funded Projects

Start Date:

07/2005

Completion Date:

06/2006

 

Abstract:

N/A

 

List of Research Outputs

 

Cheung W.M.W., Ng W.S. and Kung A.W.C., Dimethyl Sulfoxide enhances osteoblastic differentiation of murine pre-osteoblast cells, 27th Annual Meeting of the American Society for Bone & Mineral Research, September 23-27, 2005, Tennessee, USA. Journal of Bone and Mineral Research, M208. 2005.

 

Cheung W.M.W., Ng W.S. and Kung A.W.C., Dimethyl sulfoxide as an inducer of differentiation in preosteoblast MC3T3-E1 cells, FEBS Letter. 2006, 580: 121-6.

 

Cheung W.M.W., Chu W.K. and Kwong Y.L., Effects of arsenic trioxide on the cellular proliferation, apoptosis and differentiation of human neuroblastoma cells, Cancer Letters. 2006.

 

Kung A.W.C., Lai M.H., Ng M.Y.M., Cheung W.M.W., Chan V.N.Y. and Sham P.C., Estrogen receptor beta polymorphisms predict risks of osteoporosis in men and women: A linkage and association study, 27th Annual Meeting of the American Society for Bone & Mineral Research, 23-27 September 2005, Nashville, USA. 2005.

 

Kung A.W.C., Lau K.S., Cheung W.M.W. and Chan V.N.Y., Thyrotoxic periodic paralysis and polymorphisms of sodium-potassium ATPase genes, Clin Endocrinol (Oxf). 2006, 64: 158-61.

 

Lau H.L., Ng M.Y.M., Cheung W.M.W., Paterson A.D., Sham P.C., Luk K.D.K., Chan V.N.Y. and Kung A.W.C., Assessment of linkage and association of 13 genetic loci with bone mineral density, Journal of Bone and Mineral Metabolism. 2006, 24: 226-34.

 

Researcher : Chik SCC



List of Research Outputs

 

Ma L., Chan K.W., Trendell-Smith N.J., Wu A.Y.Y., Tian L., Lam A.C., Lo C.K., Chik S.C.C., Ko K.H., To K.W., Kam C.S.K., Li X., Yang C., Leung S.Y., Ng M.H. and Huang F., Systemic autoimmune disease induced by dendritic cells that have captured necrotic but not apoptotic cells in susceptible mouse strains, In: Ma L, Chan KW, Trendell-Smith NJ, Wu A, Tian L, Lam AC, Chan AK, Lo CK, Chik S, Ko KH, To CK, Kam SK, Li XS, Yang CH, Leung SY, Ng MH, Stott DI, MacPherson GG, Huang FP, European Journal of Immunology (In This Issue highlight, Editorial Comments). 2005, 35(11): 3364-75.

 

Researcher : Chim JCS



List of Research Outputs

 

Au W.Y., Lam C.C.K., Chim J.C.S., Pang A.W.K. and Kwong Y.L., Alemtuzumab induced complete remission of therapy-resistant pure red cell aplasia , Leukemia Research . 2005, 29, Issue 10: 1213-1215.

 

Au W.Y., Fung T.K., Ma E.S.K., Chan C.H., Wong K.F., Chim J.C.S., Liang R.H.S. and Kwong Y.L., Serial studies of methylation of CDKN2B and CDKN2A in relapsed acute promyelocytic leukaemia treated with arsenic trioxide, British Journal of Haematology. 2005, 131: 632.

 

Chan J.C.W., Chim J.C.S., Ooi C.G.C., Cheung B.M.Y., Liang R.H.S., Chan T.K. and Chan V.N.Y., Use of the oral chelator deferiprone in the treatment of iron overload in patients with Hb H disease, British Journal of Haematology. 2006, 133(2): 198-205.

 

Chan V.N.Y., Chan J.C.W., Chim J.C.S., Ooi C.G.C., Cheung B.M.Y., Liang R.H.S. and Chan T.K., Deferiprone in the treatment of iron overload in patients with Hb H disease, XXXth World Congress of the International Society of Hematology, Istanbul, Turkey. Istanbul, Turkey, 2005.

 

Chim J.C.S., Liang R.H.S., Leung S.M.H., Yip S.F. and Kwong Y.L., Aberrant gene promoter methylation marking disease progression in multiple myeloma, Leukemia. 2006, 20(6): 1190-2.

 

Chim J.C.S., Wong A.S.P., Pang A.W.K., Chu P., Lau J.S., Wong K.F. and Kwong Y.L., Aberrant promoter methylation of the retinoic acid receptor alpha gene in acute promyelocytic leukemia, Leukemia. 2005, 19(22): 2241-6.

 

Chim J.C.S. and Kwong Y.L., Adverse prognostic impact of CDKN2B hyper-methylationin acute promyelocytic leukemia , Leukemia & Lymphoma . 2006, 47(5): 815-25.

 

Chim J.C.S. and Ooi C.G.C., Bulbar palsy in multiple myeloma, Haematologica. 2005, 90(12Suppl): ECF42.

 

Chim J.C.S., PANG Y.Y., Ooi G.C., Mok T.M.Y. and SHEK T.W., EBV-associated synovial lymphoma in a Chronically Inflamed Joint in Rheumatoid Arthritis Receiving Prolonged Methotrexate Treatment, Haematologica. 2006, 91: 8 suppl.

 

Chim J.C.S., Wong A.S.Y. and Kwong Y.L., Epigenetic inactivation of the CIP/KIP cell-cycle control pathway in acute leukemias, American Journal of Hematology. 2005, 80(4): 282-7.

 

Chim J.C.S., Kwong Y.L., Lie A.K.W., Ma E.S.K., Chan C.C., Wong L.G., Kho B.C., Lee H.K., Sim J.P., Chan C.H., Chan J.C., Yeung Y.M., Law W. and Liang R.H.S., Long-term Outcome of 231 Patients With Essential Thrombocythemia , Archives of Internal Medicine. 2005, 165(22): 2651-8.

 

Chim J.C.S., Fung T.K., Wong K.F., Lau J.S., Law M. and Liang R.H.S., Methylation of INK4 and CIP/KIP families of cyclin-dependent kinase inhibitor in chronic lymphocytic leukaemia in Chinese patients, Journal of clinical pathology. 2006, 59(9): 921-6.

 

Chim J.C.S., Chan W.W.L., Pang A.W.K. and Kwong Y.L., Preferential methylation of Wnt inhibitory factor-1 in acute promyelocytic leukemia: an independent poor prognostic factor, Leukemia. 2006, 20(5): 907-9.

 

Chim J.C.S. and Shek T.W.H., Primary gastrointestinal lymphoma of the colo, Haematologica. 2005, 90: Suppl:EIM01.

 

Chim J.C.S., Yuen W.K., Loong F., Hu H.C. and Ooi C.G.C., Primary large B-cell lymphoma of the ampulla of vater, Haematologica. 2006, 91(3): ECR06.

 

Fong C.Y.G., Cheng T.S., Lam K., Cheng W.K., Mok B.K.Y., Cheung C.M., Chim J.C.S., Mak W., Chan K.H., Tsang K.L., Kwan M.C., Tsoi T.H., Cheung R.T.F. and Ho S.L., An epidemiological study of motor neuron disease in Hong Kong, Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. 168, 2005, 6: 164.

 

Hui C.K., Lie A.K.W., Au W.Y., Leung A.Y.H., Ma S.Y., Cheung W.W., Zhang H., Chim J.C.S., Kwong Y.L., Liang R.H.S. and Lau G., A long-term follow-up study on hepatitis B surface antigen-positive patients undergoing allogeneic hematopoietic stem cell transplantation, Blood. 2005, 106(2): 464-9.

 

Hui C.K., Ma S.Y., Sun J., Au W.Y., Lie A.K.W., Chim J.C.S., Kwong Y.L., Liang R.H.S. and Lau G., Hepatitis B reactivation in patient with occult HBV infection after chemotherapy, J Hepatol. 2005, 42(6): 813-19.

 

Leung W.H., Tsang S.F. and Chim J.C.S., Extrapulmonary tuberculous abscess in chronic lymphocytic leukaemia (CLL) treated with fludarabine: Case report and review of literature, American Journal of Hematology. 2005, 79(3): 1437-45.

 

Ooi C.G.C., Chim J.C.S., Au W.Y. and Khong P.L., Radiologic Manifestations of Primary Solitary Extramedullary and Multiple Solitary Plasmacytomas , AJR. American journal of roentgenology. 2006, 186(3): 821-7.

 

Zou B., Chim J.C.S., Lin M.C., Zeng H., He H., Yu L., Sun Y., Jiang S.H. and Wong B.C.Y., Correlation between the single-site CpG mutation within the gene promoter and the expression silencing of XIAP -Associated Factor 1 (XAF1) in human colon cancer cell lines. Asian Pacific Digestive Week, Sept. 25-28, 2005, Seoul, Korea., Journal of Gastroenterology and Hepatology. 2005, 20: Supp A253.

 

Zou B., Chim J.C.S., Lin M.C., Zeng H., He H., Yu L., Sun Y., Jiang S.H. and Wong B.C.Y., Distinguished Poster Award, "Correlation between the single-site CpG mutation within the gene promoter and the expression silencing of XIAP -Associated Factor 1 (XAF1) in human colon cancer cell lines" , Asian Pacific Digestive Week, Sept. 25-28, Seoul, Korea. 2005.

 

Researcher : Chiu PKC



List of Research Outputs

 

Wong C.P., Chiu P.K.C. and Chu L.W., Zoplicone withdrawal-an unusual cause of delirium in elderly., Age Ageing. 2005, 34: 526-527.

 

Researcher : Chow C



List of Research Outputs

 

Kwong Y.L., Chow C., Kumana C.R., Srivastava G. and Au W.Y., Arsenic trioxide in mantle cell lymphoma, Blood (American Society of Hematology 2005 Annual Meeting Abstracts) . 2005, 106 (11): 283B-284B 4814 Part 2 Nov 16 2005.

 

Leung R., Chou E.E., Au W.Y., Chow C., Kwong Y.L., Lin S.Y., Ma E.S.K., Wan T.S.K. and Wong K.F., CD4+/CD56+ hematologic malignancy with rearranged MLL gene, Human Pathology . 2006, 37(2): 247-249.

 

Researcher : Chow WH



List of Research Outputs

 

Siu C.W.D., Jim M.H., Tse H.F., Fan K., Chau M.C. and Chow W.H., Comparison of the efficacy and safety profiles fo intravenuous vitamin K and fresh frozen plasma as treatment of warfarin-related over-anticoagulation in patients with mechanical heart valves, Am J Cardiol. 2006, 97(3): 409-11.

 

Researcher : Chow WS



List of Research Outputs

 

Chow W.S., Tan K.C.B., Lam J.C.M., Lam B., Bucala R., Betteridge D.J. and Ip M.S.M., Advanced glycation end products are increased in non-diabetic patients with obstructive sleep apnea but to a lesser degree than type 2 diabetic patients, 11th Medical Research Conference of Department of Medicine, HKU. 2006.

 

Kwong Y.L., Lau W.C.S., Ho S.L., Epstein R., Young R.T.T., Chan H.H.L., Tse H.F., Lam L., Chen W.H., Lee K.L.F., Ip M.S.M., Tsang K.W.T., Lam B., Tang S.C.W., Chan R.H.W., Lee S.W.L., Tan K.C.B., Yeung C.K., Chan D.T.M., Wong R.W.S., Choy C.B.Y., Wong B.C.Y., Li F.K., Lo W.K., Lui S.L., Cheung R.T.F., Mak W., Ho J.C.M., Mok T.M.Y., Kung A.W.C., Cheung B.M.Y., Chow W.S., Yuen R.M.F. and Wat N.M.S., In: Lau CP, Kumana CR, Lai CL, Lai KN, Lam KSL, Lam WK, Problem-Based Medical Case Management. Hong Kong, Hong Kong University Press, 2005.

 

Tan K.C.B., Chow W.S., Lam J.C.M., Lam B., Bucala R., Betteridge D.J. and Ip M.S.M., Advanced glycation end products are increased in non-diabetic patients with obstructive sleep apnea but to a lesser degree than type 2 diabetic patients, 41st European Association for the Study of Diabetes Annual Meeting, Athens, Sept 2005.

 

Tan K.C.B., Chow W.S., Lam J.C.M., Lam B., Bucala R., Betteridge D.J. and Ip M.S.M., Advanced glycation end products in non-diabetic patients with obstructive sleep apnea, Sleep . 2006, 29: 329-33.

 

Tan K.C.B., Chow W.S., Lam J.C.M., Lam B., Wong W.K., Tam S. and Ip M.S.M., HDL dysfunction in obstructive sleep apnea, Atherosclerosis. 2006, 184(2): 377-82.

 

Tan K.C.B., Chow W.S., Shiu S.W.M., Bucala R. and Betteridge D.J., Increased serum level of soluble receptor for advanced glycation end products in type 2 diabetic patients with nephropathy, International Symposium on Healthy Aging, Hong Kong. 2006.

 

Tan K.C.B., Chow W.S., Shiu S.W.M., Bucala R. and Betteridge D.J., Serum level of soluble receptor for advanced glcyation end products is associated with circulating advanced glycation end products in type 2 diabetes, XIV International Symposium on Atherosclerosis, Rome. 2006.

 

Zhou H., Tan K.C.B., Chow W.S., Bucala R. and Betteridge D.J., Association between advanced glycation end products and serum cholesterol efflux capacity in type 2 diabetes mellitus, The 6th International Diabetes Federation Western Pacific Region Congress, Bangkok, Oct 2005.

 

Researcher : Choy CBY



List of Research Outputs

 

Chan L.Y., Leung J.C.K., Tang S.C.W., Choy C.B.Y. and Lai K.N., Tubular expression of angiotensin II receptors and their regulation in IgA nephropathy, Journal of American Society of Nephrology. 2005, 16(8): 2306-2317.

 

Choy C.B.Y., Chan D.T.M., Tse K.C., Lam M.F. and Lai K.N., Mycophenolic acid increase risk of herpes zoster infection in renal transplant recipients, Journal of American Society of Nephrology. 2005, 16: 835A.

 

Kwong Y.L., Lau W.C.S., Ho S.L., Epstein R., Young R.T.T., Chan H.H.L., Tse H.F., Lam L., Chen W.H., Lee K.L.F., Ip M.S.M., Tsang K.W.T., Lam B., Tang S.C.W., Chan R.H.W., Lee S.W.L., Tan K.C.B., Yeung C.K., Chan D.T.M., Wong R.W.S., Choy C.B.Y., Wong B.C.Y., Li F.K., Lo W.K., Lui S.L., Cheung R.T.F., Mak W., Ho J.C.M., Mok T.M.Y., Kung A.W.C., Cheung B.M.Y., Chow W.S., Yuen R.M.F. and Wat N.M.S., In: Lau CP, Kumana CR, Lai CL, Lai KN, Lam KSL, Lam WK, Problem-Based Medical Case Management. Hong Kong, Hong Kong University Press, 2005.

 

Yip T.P.S., Tse K.C., Lam M.F., Tang S.C.W., Li F.K., Choy C.B.Y., Lui S.L., Chan D.T.M., Lai K.N. and Lo W.K., Risk factors and outcomes of extended-spectrum beta-lactamase-producing E. coli peritonitis in CAPD patients, Peritoneal Dialysis International. 2006, 26(2): 191-197.

 

Researcher : Chu ACY



List of Research Outputs

 

Ho P.W.L., Chu A.C.Y., Kwok K.H.H., Kung M.H.W. and Ramsden D.B., Knock-down of uncoupling protein-5 (UCP5) in neuronal cells reduces mitochondrial membrane depolarization and increases oxidative stress induced by MPP+., World Parksinson Congress, Washington DC, USA. 2006, Suppl 13:: 54.

 

Pawade T., Ho W.L., Kwok H.H., Chu A.C.Y., Ho S.L. and Ramsden D.B., Uncoupling Proteins: Targets Of Endocrine Disruptors?, In: I.T. Huhtaniemi, W.E. Rainey , R.J. Rodgers , Molecular and Cellular Endocrinology. Ireland, Elsevier, 2005, 244: 79-86.

 

Song Y., Ho W.L., Kwok H.H., Chu A.C.Y., Li Y. and Ho S.L., Genetic study of a large Chinese amyotrophic lateral sclerosis family., The 55th American society of Human Genetics meeting, October 25-29, 2005, Salt Lake City Utah, USA . 2005.

 

Researcher : Chu CYA



List of Research Outputs

 

Ho W.L., Kwok H.H., Chu C.Y.A., Ho W.M., Kung M.H.W., Ramsden D.B. and Ho S.L., Silencing Of Ucp5 Enhances Mpp+-induced Neurotoxicity In Sh-sy5y Cells. , Mov Disorders. 2006, 20(10): 14.

 

Researcher : Chu LW



Project Title:

A dementia outreach programme in Central, Western and Southern districts of Hong Kong

Investigator(s):

Chu LW, Lam KSL, Lee PWH

Department:

Medicine

Source(s) of Funding:

S.K. Yee Medical Foundation - General Award

Start Date:

09/2003

 

Abstract:

To achieve early detection of dementia, through an outreach dementia-screening programme.

 

List of Research Outputs

 

Chan M.M.W., Chan F.H.W., Cheung A.H.K., Dai D.L., Chu L.W., Lam W.K., Leung C.C., Kam K.M. and Tam C.M., Prevalence of tuberculous infection and active tuberculosis in old age homes in Hong Kong., Journal of the American Geriatrics Society. 2006, 54: 1334-40.

 

Chu L.W., Geriatric Medicine in China. In: Pathy J, Morley JE, eds. Textbook in Geriatric Medicine (4th Edition). Chichester, England & New York, USA., John Wiley & Sons.. 2006, 1953-1964.

 

Chu L.W., Chi I. and Chiu A., Impact of Falls on the Balance, Gait, and Activities of Daily Living Functioning in Community-Dwelling Chinese Older Adults., Journal of Gerontol Series & Medical Science. 2006, 61(4): 399-404.

 

Chu L.W., Indications and interpretations of laboratory investigations in old age. In: Hong Kong TK, eds. Hong Kong., The HKGS Core Curriculum in Geriatric Medicine. 2006.

 

Hui S.L., Chu L.W., Peiris J.S.M., Chan K.H., Chu D. and Tsui W., Immune response to influenza vaccination in community-dwelling Chinese elderly persons., Vaccine. 2006, 24(25): 5371-80.

 

Lee T.M.C., Zhang J.X., Chan C.H., Yuen S.L., Chu L.W., Cheung R.T.F., Chan Y.S., Fox P.T. and Gao J.H., Age-related differences in response regulation as revealed by functional MRI, Brain Research. 2006, 1076(1): 171-176.

 

Tam T.C., Chan K.Y., Ho S.L., Luk J.K.H. and Chu L.W., Herpetic shoulder paresis in a Chinese elderly patient., Hong Kong Medical Journal. 2005, 11: 399-402.

 

Wong C.P., Chiu P.K.C. and Chu L.W., Zoplicone withdrawal-an unusual cause of delirium in elderly., Age Ageing. 2005, 34: 526-527.

 

Researcher : Chu WK



List of Research Outputs

 

Cheung W.M.W., Chu W.K. and Kwong Y.L., Effects of arsenic trioxide on the cellular proliferation, apoptosis and differentiation of human neuroblastoma cells, Cancer Letters. 2006.

 

Researcher : Chung SSM



Project Title:

Osmoregulation in lens

Investigator(s):

Chung SSM

Department:

Institute of Molecular Biology

Source(s) of Funding:

Outstanding RGC Projects

Start Date:

09/1998

 

Abstract:

It is imperative to have a better understanding of the mechanisms leading to various cataracts such that preventive measures can be developed. Since maintaining the ionic strength and ionic composition in the lens is essential for the transparency of the lens, we plan to study the mechanism of osmoregulation in this organ. Transgenic mice that over-express aldose reductase and sodium dependent myoinositol transporter in their lenses will be used to increase the lens' level of sorbitol and myoinositol, respectively. We will determine if high level of these osmolytes causes cataract development, and see when the level of one osmolyte is high, will the lens compensate by reducing the level of other osmolytes. We will also determine whether high intracellular osmotic pressure affects the regulation of expression of genes that control the level of osmolytes such as aldose reductase, sodium dependent myoinositol transporter, and taurine transporter.

 

Project Title:

Effects of early postnatal feeding on fatty acid metabolism

Investigator(s):

Chung SSM, Sheng HP

Department:

Institute of Molecular Biology

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

11/2002

 

Abstract:

Both epidemiological studies and animal studies have shown that prenatal and early postnatal nutrition not only affects infant growth and development, it also predetermines future metabolism, performance adn morbidity. This study addresses the problems of nutritional environment during the sucking period on lipid metabolism and later-life obesity.

 

Project Title:

Polyol pathway in diabetic dyslipidemia

Investigator(s):

Chung SSM

Department:

Institute of Molecular Biology

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

01/2003

 

Abstract:

To determine if AR null mutation reduces plasma TG levels in diabetic mice; to determine if ARI reduces plasma TG in diabetic mice; to determine if AR null mutation or ARI nor ARI normalizes LDL and HDL leviabetic mice.

 

Project Title:

Mechanism of Nogo-A inhibition of axonal regeneration

Investigator(s):

Chung SSM, Chung SK, Ju G.

Department:

Institute of Molecular Biology

Source(s) of Funding:

NSFC/RGC Joint Research Scheme

Start Date:

01/2003

 

Abstract:

To develop Nogo gene knockout mice to determine the role of this gene in the inhibition of axonal regeneration and its physiological functions; to develop transgenic mice that overexpress Nogo-A in their Schwann cells to determine if that would make their PNS non-permissive for axonal regeneraton; to develop transgenic mice that overexpress mutant Nogo-A with the Nogo-66 or aa623-640 region deleted to determine which domain is responsible for the inhibitory effect of Nogo-A.

 

Project Title:

The polyol pathway as a thrifty pathway promoting energy storage

Investigator(s):

Chung SSM

Department:

Physiology

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

09/2003

 

Abstract:

To determine the in vivo conversion of glucose to fatty acids and triglycerides in normal mice and mice deficient in AR; to determine if AR deficiency affects the activities of lipogenic/adipogenic transcriptional factors including ADD1/SREBP-1 and CHOP-C/EBP-[alpha], anti-obesity transcriptional factor FOXC2, and enzymes fatty acid synthase (FAS) and stearoyl CoA desaturase (SCD); to assess whether administration of inhibitors of aldose reductase (ARI) will affect obesity and improve glucose tolerance in the agouti yellow mice; to determine whether the effects of aldose reductase deficiency on agouti-induced lipogenesis and obesity can be duplicated in diet-induced obesity models.

 

Project Title:

The polyol pathway as a thrifty pathway promoting energy storage

Investigator(s):

Chung SSM

Department:

Physiology

Source(s) of Funding:

Merit Award for RGC CERG Funded Projects

Start Date:

09/2003

 

Abstract:

N/A

 

Project Title:

Aldose reductase in diabetic cataract

Investigator(s):

Chung SSM

Department:

Institute of Molecular Biology

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

10/2004

 

Abstract:

To determine if the antioxidant can prevent AR-induced slow-developing cataract; to determine the osmolyte content and oxidative status of the slow-developing cataract; to compare the morphological changes in the acute diabetic cataract and the slow developing cataract; to determine if there is apoptosis in the epithelial cells of the precataractous lenses.

 

Project Title:

Aldose reductase in diabetic cataract

Investigator(s):

Chung SSM

Department:

Institute of Molecular Biology

Source(s) of Funding:

Merit Award for RGC CERG Funded Projects

Start Date:

01/2005

 

Abstract:

N/A

 

Project Title:

The role of OREBP in renal osmoprotection and its contribution to chronic cyclosporine A nephrotoxicity

Investigator(s):

Chung SSM

Department:

Institute of Molecular Biology

Source(s) of Funding:

Incentive Award for RGC CERG Fundable But Not Funded Projects

Start Date:

07/2005

Completion Date:

06/2006

 

Abstract:

N/A

 

List of Research Outputs

 

Researcher : Deng X



List of Research Outputs

 

Deng X., Lau C.P. and Li G.R., Cell-cycling dependent expression of potassium channels of rat mesenchymal stem cells from bone marrow., Journal of Hong Kong College Cardiology/The 9th Institute of Cardiovascular Science and Medicine & the 5th Scientific Conference on Cardiovascular Science Across the Strait. 2005, 13: 99-OP14.

 

Deng X., Sun H., Lau C.P. and Li G.R., Modulation of voltage-gated delayed rectifier potassium channels by EGFR-mediated kinase and relation to cell proliferation in mesenchymal stem cells from rat bone marrow, 11th Medical Research Conference, The University of Hong Kong/Queen Mary Hospital . 2006.

 

Li G.R., Deng X., Sun H., Chung S.S.M., Tse H.F. and Lau C.P., Ion channels in mesenchymal stem cells from rat bone marrow. , Stem Cells. 2006, 24: 1519-1528.

 

Researcher : Dong M



List of Research Outputs

 

Dong M., Lau C.P., Gao Z., Tseng G.N. and Li G.R., Characterization of recombinant human cardiac KCNQ1/KCNE1 channels (I (Ks)) stably expressed in HEK 293 cells, In: 2006 Apr;Epub 2006 Aug 14., J Membr Biol.. 2006, 210: 183-192.

 

Tian M., Dong M., Chiu S.W., Lau C.P. and Li G.R., Effects of the antifungal antibiotic clotrimazole on human cardiac repolarization potassium currents. , British Journal of Pharmacology. 2006, 147: 289-297.

 

Researcher : Epstein R



Project Title:

Evolutionarily conserved patterns of synonymous codon bias in wild-type orthologous and paralogous gene sequences, and comparison with patterns of bias in human tumour genomes

Investigator(s):

Epstein R

Department:

Medicine

Source(s) of Funding:

Seed Funding for New Staff

Start Date:

09/2003

 

Abstract:

To clarify whether these evident associations of synonymous codon bias with function and/or with methylation are interdependent or independent.

 

Project Title:

Environmental and therapeutic modulation of tumour suppressor gene methylation

Investigator(s):

Epstein R, Smith DK

Department:

Medicine

Source(s) of Funding:

Small Project Funding

Start Date:

09/2005

 

Abstract:

Lifestyle changes in Hong Kong have been associated with a rapid rise in incidence of certain cancer types, particularly breast, colorectal and prostate cancer. The implicated lifestyle variables (diet and exercise) are not known to cause genetic mutations; it is therefore reasonable to hypothesise: 1. That environmentally induced changes in DNA methylation may contribute to this epidemiologic shift, and if so, that such inducible changes (e.g. caused by high glucose or insulin) in methylation may be detectable by appropriate in vitro model systems. A related observation is that adjuvant (preventive) anticancer treatments are uniquely effective in reducing recurrences of these same lifestyle cancers, raising the possibility that such treatments could act in part via reversing TSG methylation. In this respect it is salient to note that fluoropyrimidine drugs such as 5-fluorouracil are part of the cytotoxic regimens (CMF, FAC, 5FU/FA) for such lifestyle cancers, and that these antimetabolites are chemically related to the potent in vitro hypomethylating agent 5-azacytidine. Hence, a further hypothesis to be tested here is: 2. That TSG promoter methylation in cancer cell lines may be affected by exposures to fluoropyrimidine drugs, and if so, that this finding is relevant to the future development of more effective adjuvant cancer treatments. By providing preliminary data in support of one or other of these hypotheses, this small project grant aims to provide a basis for RGC grant applications in 2006.

 

List of Research Outputs

 

Ang K.L., Diong L.S., Wong W.K. and Epstein R., Upregulated Akt signaling adjacent to gastric cancers: implications for screening and chemoprevention., Cancer Letters. 2005, 225(1): 53-9.

 

Epstein R., "Leaving town" versus "taking leave": the case for re-thinking academic leave restrictions., Postgraduate Medical Journal. 2005, 81(962): 732-3.

 

Epstein R., Maintenance therapy to suppress micrometastasis: the new challenge for adjuvant cancer treatment. , Clinical Cancer Research. 2005, 11(15): 5337-41.

 

Epstein R., Leung T.W.T. and Cheung P.S.Y., Panmucositis and chemosensitisation associated with betel quid chewing during dose-dense adjuvant breast cancer chemotherapy. Epub 2006 Mar 11. , Cancer Chemother Pharmacol. 2006, 58(6): 835-7.

 

Epstein R., Primary prevention of human papillomavirus-dependent neoplasia: no condom, no sex. , European Journal of Cancer. 2005, 41(17): 2595-600.

 

Epstein R. and Zhao Y., Programmed Genetic Instability Revealed By Adaptive Evolution Of Caretaker Tumour Suppressor Genes, 97th Annual Meeting, American Association For Cancer Research, Washington, DC. 2006.

 

Epstein R. and Zhao Y., Racial Differences In Lung Cancer, The New England Journal Of Medicine. USA, Massachusetts Medical Society, 2006, 354: 1951-1952.

 

Epstein R., Leung T.W.T., Mak J. and Cheung P.S.Y., Utility of a web-based breast cancer predictive algorithm for adjuvant chemotherapeutic decision making in a multidisciplinary oncology center. , Cancer Investigation. Taylor & Francis, 2006, 24(4): 367-373.

 

Kwong Y.L., Lau W.C.S., Ho S.L., Epstein R., Young R.T.T., Chan H.H.L., Tse H.F., Lam L., Chen W.H., Lee K.L.F., Ip M.S.M., Tsang K.W.T., Lam B., Tang S.C.W., Chan R.H.W., Lee S.W.L., Tan K.C.B., Yeung C.K., Chan D.T.M., Wong R.W.S., Choy C.B.Y., Wong B.C.Y., Li F.K., Lo W.K., Lui S.L., Cheung R.T.F., Mak W., Ho J.C.M., Mok T.M.Y., Kung A.W.C., Cheung B.M.Y., Chow W.S., Yuen R.M.F. and Wat N.M.S., In: Lau CP, Kumana CR, Lai CL, Lai KN, Lam KSL, Lam WK, Problem-Based Medical Case Management. Hong Kong, Hong Kong University Press, 2005.

 

Yau T.C., Chu K.W., Mok T.M.Y., Liang R.H.S. and Epstein R., Acute presentation of rheumatoid arthritis following cancer chemotherapy using the topoisomerase I inhibitor irinotecan. , Acta Oncologica. 2005, 44(7): 771-772.

 

Researcher : Fong CYG



List of Research Outputs

 

Fong C.Y.G., Cheng T.S., Lam K., Cheng W.K., Mok B.K.Y., Cheung C.M., Chim J.C.S., Mak W., Chan K.H., Tsang K.L., Kwan M.C., Tsoi T.H., Cheung R.T.F. and Ho S.L., An epidemiological study of motor neuron disease in Hong Kong, Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. 168, 2005, 6: 164.

 

Researcher : Fong HY



List of Research Outputs

 

Cheung B.M.Y., Lo J.L., Fong H.Y., Chan M.Y., Wong S.H., Wong C.M., Lam K.S.L., Lau C.P. and Karlberg J.P.E., Randomised controlled trial of qigong in the treatment of mild essential hypertension, J Hum Hypertens. 2005, 19: 697-704.

 

Tso A.W.K., Wat N.M.S., Xu A., Tam S., Fong H.Y., Janus E.D., Tan K.C.B. and Lam K.S.L., Adiponectin/C-reactive protein ratio is an independent surrogate marker predictive of the development of metabolic risks and the metabolic syndrome over 5 years in Chinese, The 6th International Diabetes Federation Western Pacific Region Congress, Bangkok, Oct 2005.

 

Researcher : Fung FMY



List of Research Outputs

 

Gu Q., Xia H.H.X., Wang J., Wong R.W.M., Chan O.O., Lai K.C., Chan C.K., Yuen R.M.F., Fung F.M.Y., Wong K.W., Lam S.K. and Wong B.C.Y., Update on clarithromycin resistance in Helicobacter pylori in Hong Kong and its effect on clarithromycin-based triple therapy., Digestion. 2006, 72(2-3): 101-106.

 

Gu Q., Xia H.H.X., Wang J., Chan O.O., Lai K.C., Fung F.M.Y., Wong K.W., Cheung K.L., Kung H. and Wong B.C.Y., Update on clarithromycin resistance in Helicobacter pylori in Hong Kong and its effect on clarithromycin-based triple therapy., In: Gu Q, Xia HHX, Wang JD, Chan AOO, Lai KC, Chan CK, Yuen MF, Fung FMY, Wong KW, Cheung HKL, H.F. Kung HF, B.C.Y. Wong BCY.. , J Gastroenterol Hepatol . 2005, 20 (Suppl.): A160.

 

Wong W.M.R., Gu Q., Chu K.M., Yee Y.K., Fung F.M.Y., Tong S.M., Chan O.O.A., Lai K.C., Chan C.K. and Wong B.C.Y., Lansoprazole, levofloxacin and amoxicillin triple therapy versus quadruple therapy as second-line treatment of resistant Helicobacter pylori infection, Alimentary Pharmacology & Therapeutics. 2006, 23: 421-427.

 

Xia B., Xia H.H.X., Ma C.W., Wong K.W., Fung F.M.Y., Hui C.K., Chan C.K., Chan O.O., Lai K.C., Yuen R.M.F. and Wong B.C.Y., Trends in the prevalence of peptic ulcer disease and Helicobacter pylori infection in family physician-referred uninvestigated dyspeptic patients in Hong Kong. , Alimentary Pharmacology and Therapeutics. 2005, 22(3): 243-9.

 

Xia H.H.X., Wong R.W.M., Chan O.O., Lam S.K., Lai K.C., Chan C.K., Cheung K.L., Fung F.M.Y., Wong K.W. and Wong B.C.Y., Natural acquisition of Helicobacter pylori in adult dyspeptic patients with or without previous infection – a 7-year follow-up study. Australian Gastroenterology Week 2005, 19 October 2005, Australia. , Journal of Gastroenterology and Hepatology. 2005, 20: Supp A112.

 

Researcher : Fung JYY



List of Research Outputs

 

Yuen R.M.F., Sablon E., Libbrecht E., Van de Velde H., Wong D.K.H., Fung J.Y.Y., Wong B.C.Y. and Lai C.L., Significance of HBV DNA, core promoter/precore mutations, genotypes, specific sequences of polymerase gene on three-year lamivudine treatment: A predictive model for antiviral therapy, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2006, 44 (Suppl 2): S194.

 

Researcher : Fung PCW



Project Title:

Development of a novel natural antioxidant with strong anti-aging and protective properties for skin

Investigator(s):

Fung PCW, Shen J

Department:

Medicine

Source(s) of Funding:

Seed Funding Programme for Applied Research

Start Date:

07/2002

 

Abstract:

To develop a novel antioxidants from herbal products which can scavenge superoxide, hydroxyl and lipid peroxide free radicals in skin.

 

Project Title:

Roles of plasma membrane cholesterol homeostasis in regulating neuronal oxidative damage of ischemic stroke

Investigator(s):

Fung PCW, Shen J

Department:

Medicine

Source(s) of Funding:

Small Project Funding

Start Date:

11/2003

 

Abstract:

To understand the roles of plasma membrane cholesterol homeostasis in protecting neuronal cells from oxidative damage during ischemic stroke.

 

Project Title:

High level brain activity studies and applications

Investigator(s):

Fung PCW, Chang C, Gao S.K., Gao X.R., Zhang Z.G., Yang F.S., Poon P.W.F., Chan FHY

Department:

Medicine

Source(s) of Funding:

NSFC/RGC Joint Research Scheme

Start Date:

01/2004

 

Abstract:

To better understand and utilize the functioning of the brain.

 

List of Research Outputs

 

Chan P.S., Shen J., Fung P.C.W. and Cheung R.T.F., NPY acts on its Y1 receptor via Ca2+ as the second messenger to cause NO overproduction and mediate cell injury following oxygen and glucose deprivation in SK-N-MC cells, 11th Medical Research Conference, Medical Science Group. 2006, 81.

 

Chang C., Hung Y.S., Fung P.C.W. and Ding Z., Network component analysis for blind source separation, 2006 International Conference on Communications, Circuits and Systems. Guilin, China, UESTC, 2006, I: 323-326.

 

Chang C., Xu W., Hung Y.S. and Fung P.C.W., Nonlinear Dynamic Characterization of Intra-atrial ECG Signals, European Study Group on Cardiovascular Oscillations, 2006, Jena, Germany. 2006.

 

Chang C., Fung P.C.W. and Hung Y.S., On a sparse component analysis approach to blind source separation, Independent Component Analysis and Blind Signal Separation: 6th Internal Conference ICA 2006, Charleston, SC, USA. 2006, 3889: 765-772.

 

Leung Y.Y., Chang C., Hung Y.S. and Fung P.C.W., Gene Selection in Microarray Data Analysis for Brain Cancer Classification, IEEE International Workshop on Genomic Signal Processing and Statistics (GENSIPS 2006), Texas A&M University, USA. 2006.

 

Shen J., Ma S.K.Y., Chan P., Lee W., Fung P.C.W., Cheung R.T.F., Tong Y. and Liu K.J., Nitric oxide down-regulates caveolin-1 expression in rat brains during focal cerebral ischemia and reperfusion injury, Journal of Neurochemistry. 2006, 96(4): 1078-89.

 

Xu R., Rahimi M., Ma H., Fung P.C.W., Chang C., Xu S. and During M., Stability of infectious recombinant adeno-associated viral vector in gene delivery, Medical Science Monitor. 2005, 11: 305-308.

 

Researcher : Fung TK



List of Research Outputs

 

Au W.Y., Fung T.K. and Liang R.H.S., Molecular epidemiology of follicular lymphoma in Chinese: relationship with bcl-2IgH translocation and bcl-6 397G/C polymorphism, Annals of Hematology. 2005, 84(8): 506-9.

 

Au W.Y., Fung T.K., Ma E.S.K., Chan C.H., Wong K.F., Chim J.C.S., Liang R.H.S. and Kwong Y.L., Serial studies of methylation of CDKN2B and CDKN2A in relapsed acute promyelocytic leukaemia treated with arsenic trioxide, British Journal of Haematology. 2005, 131: 632.

 

Au W.Y., Ma E.S.K., Choy C., Chung L.P., Fung T.K., Liang R.H.S. and Kwong Y.L., Therapy-related lymphomas in patients with autoimmune diseases after treatment with disease-modifying anti-rheumatic drugs, American Journal of Hematology. 2005, 81(1): 5-11.

 

Chim J.C.S., Fung T.K., Wong K.F., Lau J.S., Law M. and Liang R.H.S., Methylation of INK4 and CIP/KIP families of cyclin-dependent kinase inhibitor in chronic lymphocytic leukaemia in Chinese patients, Journal of clinical pathology. 2006, 59(9): 921-6.

 

Researcher : Gao Z



List of Research Outputs

 

Dong M., Lau C.P., Gao Z., Tseng G.N. and Li G.R., Characterization of recombinant human cardiac KCNQ1/KCNE1 channels (I (Ks)) stably expressed in HEK 293 cells, In: 2006 Apr;Epub 2006 Aug 14., J Membr Biol.. 2006, 210: 183-192.

 

Researcher : Gu J



List of Research Outputs

 

Gu J., Lai M.H., Chan V.N.Y. and Kung A.W.C., Association of estrogen receptor beta gene polymorphisms and rate of bone loss in perimenopausal women, 27th Annual Meeting of the American Society for Bone & Mineral Research, 23-27 September 2005, Nashville, USA. 2005.

 

Researcher : Gu Q



List of Research Outputs

 

Fan X.M., Jiang X., Gu Q., Ching Y.P., He H., Xia H.H.X., Lin M.C., Chan O.O., Yuen R.M.F., Kung H.F. and Wong B.C.Y., Inhibition of Akt/PKB by a COX-2 Inhibitor Induces Apoptosis in Gastric Cancer Cells, Digestion. 2006, 73(2-3): 75-83.

 

Gu Q., Xia H.H.X., Wang J., Wong R.W.M., Chan O.O., Lai K.C., Chan C.K., Yuen R.M.F., Fung F.M.Y., Wong K.W., Lam S.K. and Wong B.C.Y., Update on clarithromycin resistance in Helicobacter pylori in Hong Kong and its effect on clarithromycin-based triple therapy., Digestion. 2006, 72(2-3): 101-106.

 

Gu Q., Xia H.H.X., Wang J., Chan O.O., Lai K.C., Fung F.M.Y., Wong K.W., Cheung K.L., Kung H. and Wong B.C.Y., Update on clarithromycin resistance in Helicobacter pylori in Hong Kong and its effect on clarithromycin-based triple therapy., In: Gu Q, Xia HHX, Wang JD, Chan AOO, Lai KC, Chan CK, Yuen MF, Fung FMY, Wong KW, Cheung HKL, H.F. Kung HF, B.C.Y. Wong BCY.. , J Gastroenterol Hepatol . 2005, 20 (Suppl.): A160.

 

He H., Xia H.H.X., Wang J., Gu Q., Lin M.C., Zou B., Lam S.K., Chan O.O., Yuen R.M.F., Kung H.F. and Wong B.C.Y., Inhibition of human telomerase reverse transcriptase by nonsteroidal antiinflammatory drugs in colon carcinoma, Cancer. 2006, 106(6): 1243-9.

 

Li G., Xia H.H.X., Chen M., Gu Q., Wang J., Peng J., Chan O.O., Cho C.H., So H.L., Lam S.K., Hu P.J., Liang Y.J., Lin H., Berg D.E., Feng Z.H., Langenback R. and Wong B.C.Y., Effects of Cyclooxygenase-1 and -2 Gene Disruption on Helicobacter pylori-Induced Inflammation, Journal of Infectious Diseases. 2006, 193(7): 1037-1046.

 

Wang J., He H., Yu L., Xia H.H.X., Lin M.C., Gu Q., Li M., Zou B., An X.M., Jiang B., Kung H.F. and Wong B.C.Y., HSF1 down-regulates XAF1 through transcriptional regulation, Journal of Biological Chemistry. 2006, 281(5): 2451-2459.

 

Wong W.M.R., Gu Q., Chu K.M., Yee Y.K., Fung F.M.Y., Tong S.M., Chan O.O.A., Lai K.C., Chan C.K. and Wong B.C.Y., Lansoprazole, levofloxacin and amoxicillin triple therapy versus quadruple therapy as second-line treatment of resistant Helicobacter pylori infection, Alimentary Pharmacology & Therapeutics. 2006, 23: 421-427.

 

Xia H.H.X., He H., Wang J., Gu Q., Lin M.C., Zou B., Yu L., Sun Y., Chan O.O., Kung H.F. and Wong B.C.Y., Induction of apoptosis and cell cycle arrest by a specific c-Jun NH(2)-terminal kinase (JNK) inhibitor, SP-600125, in gastrointestinal cancers., Cancer Letters. 2005, 241(2): 268-74.

 

Researcher : Gu Q



List of Research Outputs

 

Fan X.M., Jiang X., Gu Q., Ching Y.P., He H., Xia H.H.X., Lin M.C., Chan O.O., Yuen R.M.F., Kung H.F. and Wong B.C.Y., Inhibition of Akt/PKB by a COX-2 Inhibitor Induces Apoptosis in Gastric Cancer Cells, Digestion. 2006, 73(2-3): 75-83.

 

Gu Q., Xia H.H.X., Wang J., Wong R.W.M., Chan O.O., Lai K.C., Chan C.K., Yuen R.M.F., Fung F.M.Y., Wong K.W., Lam S.K. and Wong B.C.Y., Update on clarithromycin resistance in Helicobacter pylori in Hong Kong and its effect on clarithromycin-based triple therapy., Digestion. 2006, 72(2-3): 101-106.

 

Gu Q., Xia H.H.X., Wang J., Chan O.O., Lai K.C., Fung F.M.Y., Wong K.W., Cheung K.L., Kung H. and Wong B.C.Y., Update on clarithromycin resistance in Helicobacter pylori in Hong Kong and its effect on clarithromycin-based triple therapy., In: Gu Q, Xia HHX, Wang JD, Chan AOO, Lai KC, Chan CK, Yuen MF, Fung FMY, Wong KW, Cheung HKL, H.F. Kung HF, B.C.Y. Wong BCY.. , J Gastroenterol Hepatol . 2005, 20 (Suppl.): A160.

 

He H., Xia H.H.X., Wang J., Gu Q., Lin M.C., Zou B., Lam S.K., Chan O.O., Yuen R.M.F., Kung H.F. and Wong B.C.Y., Inhibition of human telomerase reverse transcriptase by nonsteroidal antiinflammatory drugs in colon carcinoma, Cancer. 2006, 106(6): 1243-9.

 

Li G., Xia H.H.X., Chen M., Gu Q., Wang J., Peng J., Chan O.O., Cho C.H., So H.L., Lam S.K., Hu P.J., Liang Y.J., Lin H., Berg D.E., Feng Z.H., Langenback R. and Wong B.C.Y., Effects of Cyclooxygenase-1 and -2 Gene Disruption on Helicobacter pylori-Induced Inflammation, Journal of Infectious Diseases. 2006, 193(7): 1037-1046.

 

Wang J., He H., Yu L., Xia H.H.X., Lin M.C., Gu Q., Li M., Zou B., An X.M., Jiang B., Kung H.F. and Wong B.C.Y., HSF1 down-regulates XAF1 through transcriptional regulation, Journal of Biological Chemistry. 2006, 281(5): 2451-2459.

 

Wong W.M.R., Gu Q., Chu K.M., Yee Y.K., Fung F.M.Y., Tong S.M., Chan O.O.A., Lai K.C., Chan C.K. and Wong B.C.Y., Lansoprazole, levofloxacin and amoxicillin triple therapy versus quadruple therapy as second-line treatment of resistant Helicobacter pylori infection, Alimentary Pharmacology & Therapeutics. 2006, 23: 421-427.

 

Xia H.H.X., He H., Wang J., Gu Q., Lin M.C., Zou B., Yu L., Sun Y., Chan O.O., Kung H.F. and Wong B.C.Y., Induction of apoptosis and cell cycle arrest by a specific c-Jun NH(2)-terminal kinase (JNK) inhibitor, SP-600125, in gastrointestinal cancers., Cancer Letters. 2005, 241(2): 268-74.

 

Researcher : Guo H



List of Research Outputs

 

Guo H., Leung J.C.K., Chan L.Y., Lui S.L., Tsang W.L. and Lai K.N., Modulation of intra-pulmonary TGF-beta expression by mycophenolate mofetil in lupus prone MRL/lpr mice, Lupus. 2005, 14(8): 583-592.

 

Researcher : He H



List of Research Outputs

 

Fan X.M., Jiang X., Gu Q., Ching Y.P., He H., Xia H.H.X., Lin M.C., Chan O.O., Yuen R.M.F., Kung H.F. and Wong B.C.Y., Inhibition of Akt/PKB by a COX-2 Inhibitor Induces Apoptosis in Gastric Cancer Cells, Digestion. 2006, 73(2-3): 75-83.

 

He H., Xia H.H.X., Wang J., Gu Q., Lin M.C., Zou B., Lam S.K., Chan O.O., Yuen R.M.F., Kung H.F. and Wong B.C.Y., Inhibition of human telomerase reverse transcriptase by nonsteroidal antiinflammatory drugs in colon carcinoma, Cancer. 2006, 106(6): 1243-9.

 

Wang J., Peng Y., Sun Y., He H., Zhu S., An X.M., Li M., Lin M.C., Zou B., Xia H.H.X., Jiang B., Chan O.O., Yuen R.M.F., Kung H.F. and Wong B.C.Y., All-Trans Retinoic Acid Induces XAF1 Expression Through an Interferon Regulatory Factor-1 Element in Colon Cancer, Gastroenterology. 2006, 130(3): 747-758.

 

Wang J., He H., Yu L., Xia H.H.X., Lin M.C., Gu Q., Li M., Zou B., An X.M., Jiang B., Kung H.F. and Wong B.C.Y., HSF1 down-regulates XAF1 through transcriptional regulation, Journal of Biological Chemistry. 2006, 281(5): 2451-2459.

 

Xia H.H.X., He H., Wang J., Gu Q., Lin M.C., Zou B., Yu L., Sun Y., Chan O.O., Kung H.F. and Wong B.C.Y., Induction of apoptosis and cell cycle arrest by a specific c-Jun NH(2)-terminal kinase (JNK) inhibitor, SP-600125, in gastrointestinal cancers., Cancer Letters. 2005, 241(2): 268-74.

 

Zou B., Chim J.C.S., Lin M.C., Zeng H., He H., Yu L., Sun Y., Jiang S.H. and Wong B.C.Y., Correlation between the single-site CpG mutation within the gene promoter and the expression silencing of XIAP -Associated Factor 1 (XAF1) in human colon cancer cell lines. Asian Pacific Digestive Week, Sept. 25-28, 2005, Seoul, Korea., Journal of Gastroenterology and Hepatology. 2005, 20: Supp A253.

 

Zou B., Chim J.C.S., Lin M.C., Zeng H., He H., Yu L., Sun Y., Jiang S.H. and Wong B.C.Y., Distinguished Poster Award, "Correlation between the single-site CpG mutation within the gene promoter and the expression silencing of XIAP -Associated Factor 1 (XAF1) in human colon cancer cell lines" , Asian Pacific Digestive Week, Sept. 25-28, Seoul, Korea. 2005.

 

Zou B., Lin M.C., Lam S.K., Tu S., Zeng H., Yang Y., Wang J., He H., Jiang S.H., Kung H. and Wong B.C.Y., Distinguished Poster Award, "Hypermethylation status around exon 1 of XIAP-Associated Factor 1(XAF1) in human gastric and colon cancer cell line.", Asian Pacific Digestive Week, Sept. 25-28, Seoul, Korea.. 2005.

 

Zou B., Lin M.C., Lam S.K., Tu S., Zeng H., Yang Y., Wang J., He H., Jiang S.H., Kung H. and Wong B.C.Y., Hypermethylation status around exon 1 of XIAP-Associated Factor 1(XAF1) in human gastric and colon cancer cell line. Asian Pacific Digestive Week, Sept. 25-28, 2005, Seoul, Korea. , Journal of Gastroenterology and Hepatology. 2005, 20: Supp A370.

 

Researcher : He H



List of Research Outputs

 

Fan X.M., Jiang X., Gu Q., Ching Y.P., He H., Xia H.H.X., Lin M.C., Chan O.O., Yuen R.M.F., Kung H.F. and Wong B.C.Y., Inhibition of Akt/PKB by a COX-2 Inhibitor Induces Apoptosis in Gastric Cancer Cells, Digestion. 2006, 73(2-3): 75-83.

 

He H., Xia H.H.X., Wang J., Gu Q., Lin M.C., Zou B., Lam S.K., Chan O.O., Yuen R.M.F., Kung H.F. and Wong B.C.Y., Inhibition of human telomerase reverse transcriptase by nonsteroidal antiinflammatory drugs in colon carcinoma, Cancer. 2006, 106(6): 1243-9.

 

Wang J., Peng Y., Sun Y., He H., Zhu S., An X.M., Li M., Lin M.C., Zou B., Xia H.H.X., Jiang B., Chan O.O., Yuen R.M.F., Kung H.F. and Wong B.C.Y., All-Trans Retinoic Acid Induces XAF1 Expression Through an Interferon Regulatory Factor-1 Element in Colon Cancer, Gastroenterology. 2006, 130(3): 747-758.

 

Wang J., He H., Yu L., Xia H.H.X., Lin M.C., Gu Q., Li M., Zou B., An X.M., Jiang B., Kung H.F. and Wong B.C.Y., HSF1 down-regulates XAF1 through transcriptional regulation, Journal of Biological Chemistry. 2006, 281(5): 2451-2459.

 

Xia H.H.X., He H., Wang J., Gu Q., Lin M.C., Zou B., Yu L., Sun Y., Chan O.O., Kung H.F. and Wong B.C.Y., Induction of apoptosis and cell cycle arrest by a specific c-Jun NH(2)-terminal kinase (JNK) inhibitor, SP-600125, in gastrointestinal cancers., Cancer Letters. 2005, 241(2): 268-74.

 

Zou B., Chim J.C.S., Lin M.C., Zeng H., He H., Yu L., Sun Y., Jiang S.H. and Wong B.C.Y., Correlation between the single-site CpG mutation within the gene promoter and the expression silencing of XIAP -Associated Factor 1 (XAF1) in human colon cancer cell lines. Asian Pacific Digestive Week, Sept. 25-28, 2005, Seoul, Korea., Journal of Gastroenterology and Hepatology. 2005, 20: Supp A253.

 

Zou B., Chim J.C.S., Lin M.C., Zeng H., He H., Yu L., Sun Y., Jiang S.H. and Wong B.C.Y., Distinguished Poster Award, "Correlation between the single-site CpG mutation within the gene promoter and the expression silencing of XIAP -Associated Factor 1 (XAF1) in human colon cancer cell lines" , Asian Pacific Digestive Week, Sept. 25-28, Seoul, Korea. 2005.

 

Zou B., Lin M.C., Lam S.K., Tu S., Zeng H., Yang Y., Wang J., He H., Jiang S.H., Kung H. and Wong B.C.Y., Distinguished Poster Award, "Hypermethylation status around exon 1 of XIAP-Associated Factor 1(XAF1) in human gastric and colon cancer cell line.", Asian Pacific Digestive Week, Sept. 25-28, Seoul, Korea.. 2005.

 

Zou B., Lin M.C., Lam S.K., Tu S., Zeng H., Yang Y., Wang J., He H., Jiang S.H., Kung H. and Wong B.C.Y., Hypermethylation status around exon 1 of XIAP-Associated Factor 1(XAF1) in human gastric and colon cancer cell line. Asian Pacific Digestive Week, Sept. 25-28, 2005, Seoul, Korea. , Journal of Gastroenterology and Hepatology. 2005, 20: Supp A370.

 

Researcher : Ho JCM



List of Research Outputs

 

Ho J.C.M., Advances in non-small cell lung cancer treatment, 11th Hong Kong Medical Forum, HKU, 4 June. 2006.

 

Ho J.C.M., An advanced approach in managing asthma exacerbation, QualityHealth Care CME programme, 16 August. 2005.

 

Ho J.C.M., Bronchogenic carcinoma: epidemiology, investigations and treatment, Post-registration certificate course in respiratory nursing. Institute of Advanced Nursing Studies, Hospital Authority. 2 May. 2006.

 

Ho J.C.M., Lung cancer screening, Lung cancer screening. Hong Kong Thoracic Society Annual Scientific Meeting, 19 March. 2006.

 

Ho J.C.M., Lung cancer screening, The Society of Physicians of Hong Kong, Sunday symposium, 11 December. 2005.

 

Ho J.C.M., Wong M.P. and Lam W.K., Lymphoepithelioma-like carcinoma of the lung, Respirology. 2006, 11: 539-545.

 

Ho J.C.M., Mak J.C.W., Ho S., Ip M.S.M., Tsang K.W.T., Lam W.K. and Chan M.M.W., Manganese superoxide dismutase and catalase genetic polymorphisms, activity levels and lung cancer risk in Chinese in Hong Kong. 11th World Conference on Lung Cancer , Lung Cancer. 2005, 49(Suppl 2): S191.

 

Ho J.C.M., Chua D.T.T., Cheng A.C., Sham J.S.T., Lam W.K. and Wong M.P., Predictive role of mutational status of epidermal growth factor receptor in clinical response to gefitinib in advanced non-small cell lung cancer, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong . 2006, Abstract Book: pp. 58.

 

Ho J.C.M., Tsang K.W.T. and Lam W.K., Respiratory Medicine-Long Cases , in CP Lau (eds), Problem-based medical case mangement. Hong Kong, Hong Kong University Press, 2006, 215-230.

 

Ho J.C.M., Tsang K.W.T. and Lam W.K., Respiratory Medicine-Short Cases , in CP Lau (eds), Problem-based medical case management. Hong Kong, Hong Kong University Press, 2006, 193-214.

 

Ho P.L., Chau P.H., Yip P.S.F., Ooi C.G.C., Khong P.L., Ho J.C.M., Wong P.C., Ko C.F., Yan C.P.K. and Tsang K.W.T., A prediction rule for clinical diagnosis of severe acute respiratory syndrome, European Respiratory Journal. 2005, 26(3): 474-9.

 

Kwong Y.L., Lau W.C.S., Ho S.L., Epstein R., Young R.T.T., Chan H.H.L., Tse H.F., Lam L., Chen W.H., Lee K.L.F., Ip M.S.M., Tsang K.W.T., Lam B., Tang S.C.W., Chan R.H.W., Lee S.W.L., Tan K.C.B., Yeung C.K., Chan D.T.M., Wong R.W.S., Choy C.B.Y., Wong B.C.Y., Li F.K., Lo W.K., Lui S.L., Cheung R.T.F., Mak W., Ho J.C.M., Mok T.M.Y., Kung A.W.C., Cheung B.M.Y., Chow W.S., Yuen R.M.F. and Wat N.M.S., In: Lau CP, Kumana CR, Lai CL, Lai KN, Lam KSL, Lam WK, Problem-Based Medical Case Management. Hong Kong, Hong Kong University Press, 2005.

 

Mak J.C.W., Ho J.C.M., Ho S.P., Leung C.M., Law K.W., Lam W.K., Ip M.S.M. and Chan M.M.W., Polymorphisms in superoxide dismutase (SOD) and catalase genes - functional study in Chinese patients with asthma, Hong Kong Allergy Convention, Hong Kong. 2005, Abstract AB26: p.54.

 

Ooi C.G.C., Ho J.C.M., Lam B., Lai A.Y.K., Tsang K.W.T. and Lam W.K., Relationship between MR intra-abdominal fat parameters and cardiovascular risk parameters in obstructive sleep apnoea, Respirology. 2005, 10 (Suppl): A176 (#366).

 

Wang J., Ho J.C.M., Lam W.K., Ip M.S.M., Chan M.M.W. and Tsang K.W.T., Lymphoepithelioma-like-carcinoma of the lung : experience with 13 cases, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2006, Abstract Book 104: pp. 59.

 

Wong M.P., Chua D.T.T., Ho J.C.M., Tam I.Y.S., Lam W.K. and Chung L.P., Mutational status of epidermal growth factor receptor is the only predictor of clinical response to gefitinib treatment in non-small cell lung cancer, 97th AACR Annual Meeting, Washington, DC, April 1-5, 2006 . 2006.

 

Researcher : Ho SL



List of Research Outputs

 

Chan K.H., Mak W., Cheung R.T.F., Cheng T.S. and Ho S.L., Muscle-specific kinase autoantibody in acetylcholine receptor antibody-negative generalized acquired myasthenia gravis, 11th Medical Research Conference, Medical Science Group. 2006, 80.

 

Fong C.Y.G., Cheng T.S., Lam K., Cheng W.K., Mok B.K.Y., Cheung C.M., Chim J.C.S., Mak W., Chan K.H., Tsang K.L., Kwan M.C., Tsoi T.H., Cheung R.T.F. and Ho S.L., An epidemiological study of motor neuron disease in Hong Kong, Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. 168, 2005, 6: 164.

 

Ho W.L., Kwok H.H., Chu C.Y.A., Ho W.M., Kung M.H.W., Ramsden D.B. and Ho S.L., Silencing Of Ucp5 Enhances Mpp+-induced Neurotoxicity In Sh-sy5y Cells. , Mov Disorders. 2006, 20(10): 14.

 

Kwong Y.L., Lau W.C.S., Ho S.L., Epstein R., Young R.T.T., Chan H.H.L., Tse H.F., Lam L., Chen W.H., Lee K.L.F., Ip M.S.M., Tsang K.W.T., Lam B., Tang S.C.W., Chan R.H.W., Lee S.W.L., Tan K.C.B., Yeung C.K., Chan D.T.M., Wong R.W.S., Choy C.B.Y., Wong B.C.Y., Li F.K., Lo W.K., Lui S.L., Cheung R.T.F., Mak W., Ho J.C.M., Mok T.M.Y., Kung A.W.C., Cheung B.M.Y., Chow W.S., Yuen R.M.F. and Wat N.M.S., In: Lau CP, Kumana CR, Lai CL, Lai KN, Lam KSL, Lam WK, Problem-Based Medical Case Management. Hong Kong, Hong Kong University Press, 2005.

 

Leung K.P., Kwok T.K., Li L.S.W. and Ho S.L., Autonomic studies on two patients with advanced motor neuron disease and unexplained resting tachycardia., World Congress of Neurological Rehabilitation, Hong Kong. 2006.

 

Luk J.K.H., Cheung R.T.F., Ho S.L. and Li L.S.W., Does age predict outcome in stroke rehabilitation? A study of 878 Chinese subjects, 4th World Congress for NeuroRehabilitation. 2006, 20: 174.

 

Luk J.K.H., Cheung R.T.F., Ho S.L. and Li L.S.W., Does age predict outcome in stroke rehabilitation? A study of 878 Chinese subjects, Cerebrovascular Diseases. 2006, 21: 229-234.

 

Mak W., Cheng T.S., Chan K.H., Cheung R.T.F. and Ho S.L., A possible explanation for the racial difference in distribution of large-arterial cerebrovascular disease: Ancestral European settlers evolved genetic resistance to atherosclerosis, but confined to the intracranial arteries, Medical Hypotheses. 2005, 65: 637-648.

 

Mak W., Kwan M.W., Cheng T.S., Chan K.H., Cheung R.T.F. and Ho S.L., Cerebrospinal fluid to serum glucose ratio in non-hypoglycorrhachic conditions, Hong Kong Medical Journal. 2005, 11: 457-462.

 

Mak W., Kwan M.W.M., Cheng T.S., Chan K.H., Cheung R.T.F. and Ho S.L., Myopia as a latent phenotype of a pleiotropic gene positively selected for facilitating neurocognitive development, and the effects of environmental factors in its expression, Medical Hypotheses. 2006, 6: 1209-1215.

 

Mak W., Cheng T.S., Leung K.P., Li L.S.W. and Ho S.L., PBL video trigger on "Motor Neuron Disease", TDG projectVirtual Reality Teaching and Learning Resource Bank for Medical Education.. 2006.

 

Ng M.C., Ho J.T., Ho S.L., Lee R., Li G., Song Y., Chan K.H., Cheng T.S., Yang E.S. and Leong L.Y., Asymptomatic members with SOD1 mutation in a large kindred with familial amyotrophic lateral sclerosis have abnormal water diffusion characterisitcs., The International Society for Magnetic Resonance in Medicine (ISMRM2006). 6-12 May 2006, Seattle, Washington, USA. 2006.

 

Pawade T., Ho W.L., Kwok H.H., Chu A.C.Y., Ho S.L. and Ramsden D.B., Uncoupling Proteins: Targets Of Endocrine Disruptors?, In: I.T. Huhtaniemi, W.E. Rainey , R.J. Rodgers , Molecular and Cellular Endocrinology. Ireland, Elsevier, 2005, 244: 79-86.

 

Salama A.S., Ho S.L., Wang H.Q., Tenhunen J. and AI-Hendy A., Hormonal regulation of catechol-O-methyltransferase activity in uterine leimyoma., 52nd Annual Scientific Meeting, Society of Gynaecologic Investigations, Los Angeles, USA.. 2005.

 

Song Y., Ho W.L., Kwok H.H., Chu A.C.Y., Li Y. and Ho S.L., Genetic study of a large Chinese amyotrophic lateral sclerosis family., The 55th American society of Human Genetics meeting, October 25-29, 2005, Salt Lake City Utah, USA . 2005.

 

Tam T.C., Chan K.Y., Ho S.L., Luk J.K.H. and Chu L.W., Herpetic shoulder paresis in a Chinese elderly patient., Hong Kong Medical Journal. 2005, 11: 399-402.

 

Researcher : Ho SP



List of Research Outputs

 

Mak J.C.W., Leung C.M., Ho S.P., Law K.W., Ho A.S.S., Lam W.K., Ip M.S.M. and Chan M.M.W., Analysis of transforming growth factor-beta(1) gene polymorphisms in Hong Kong Chinese asthmatic patients, Journal of Allergy and Clinical Immunology. 2006, 117: 92-96.

 

Mak J.C.W., Leung C.M., Ho S.P., Law K.W., Tsang K.W.T., Lam W.K., Ip M.S.M. and Chan M.M.W., Best Poster - Genetic Susceptibility Of Transforming Growth Factor-beta1 Common Polymorphisms To Chinese Patients With Asthma, Hong Kong Allergy Convention 2005 . 2005.

 

Mak J.C.W., Ho S.P., Leung Y.H., Ho P.L., Ooi C.G.C., Tipoe G.L., Yan C.P.K., Ip M.S.M., Lam W.K. and Tsang K.W.T., Elevated levels of transforming growth factor-beta(1) in serum of patients with stable bronchiectasis, Respiratory Medicine. 2005, 99: 1223-1228.

 

Mak J.C.W., Leung C.M., Ho S.P., Law K.W., Tsang K.W.T., Lam W.K., Ip M.S.M. and Chan M.M.W., Genetic susceptibility of transforming growth factor-beta(1) common polymorphisms to Chinese patients with asthma, Hong Kong Allergy Convention, Hong Kong. 2005, Abstract AB25: p.54.

 

Mak J.C.W., Ho S.P., Leung C.M., Lam W.K., Ip M.S.M. and Chan M.M.W., Genetic susceptibility to chronic obstructive pulmonary disease (COPD) : Transforming growth factor-beta common polymorphisms and plasma levels, American Journal of Respiratory and Critical Care Medicine. 2006, 173(3): A624.

 

Mak J.C.W., Ho S.P., Leung C.M., Lam W.K., Ip M.S.M. and Chan M.M.W., Genetic susceptibility to chronic obstructive pulmonary disease (COPD) : transforming growth factor-beta(1) common polymorphisms and plasma levels, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong, January 2006. Abstract Book 089: pp.56.

 

Mak J.C.W., Hui W.S., Ho S.P., So W.H.L., Chan M.M.W., Cho C.H. and Lam W.K., Inducation of CINC-1 in the lung tissue from rats exposed to cigarette smoke, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2006, Abstract Book 088: pp. 55.

 

Mak J.C.W., Hui W.S., Ho S.P., So W.H., Chan M.M.W., Cho C.H. and Lam W.K., Induction of CINC-1 in the lung tissue from rats exposed to cigarette smoke, American Journal of Respiratory and Critical Care Medicine. 2006, 173(3): A634.

 

Mak J.C.W., Leung C.M., Ho S.P., Ko F.W.S., Cheung A.H.K., Ip M.S.M. and Chan M.M.W., Polymorphisms in manganese superoxide dismutase and catalase genes - functional study in Hong Kong Chinese asthma patients , Clinical and Experimental Allergy. 2006, 36: 440-447.

 

Mak J.C.W., Ho J.C.M., Ho S.P., Leung C.M., Law K.W., Lam W.K., Ip M.S.M. and Chan M.M.W., Polymorphisms in superoxide dismutase (SOD) and catalase genes - functional study in Chinese patients with asthma, Hong Kong Allergy Convention, Hong Kong. 2005, Abstract AB26: p.54.

 

Mak J.C.W., Ho S.P., Wong M.P., Tsang K.W.T., Ip M.S.M., Lam W.K. and Chan M.M.W., Transforming growth factor (TGF)-b[sub]1[/sub] gene common polymorphisms and plasma TGF-b[sub]1[/sub] levels in patients with lung cancer, European Respiratory Journal. 2005, 26 (Suppl 49): 435S (#2797).

 

Researcher : Ho WL



List of Research Outputs

 

Ho W.L., Kwok H.H., Chu C.Y.A., Ho W.M., Kung M.H.W., Ramsden D.B. and Ho S.L., Silencing Of Ucp5 Enhances Mpp+-induced Neurotoxicity In Sh-sy5y Cells. , Mov Disorders. 2006, 20(10): 14.

 

Pawade T., Ho W.L., Kwok H.H., Chu A.C.Y., Ho S.L. and Ramsden D.B., Uncoupling Proteins: Targets Of Endocrine Disruptors?, In: I.T. Huhtaniemi, W.E. Rainey , R.J. Rodgers , Molecular and Cellular Endocrinology. Ireland, Elsevier, 2005, 244: 79-86.

 

Song Y., Ho W.L., Kwok H.H., Chu A.C.Y., Li Y. and Ho S.L., Genetic study of a large Chinese amyotrophic lateral sclerosis family., The 55th American society of Human Genetics meeting, October 25-29, 2005, Salt Lake City Utah, USA . 2005.

 

Researcher : Ho WL



List of Research Outputs

 

Ho W.L., Kwok H.H., Chu C.Y.A., Ho W.M., Kung M.H.W., Ramsden D.B. and Ho S.L., Silencing Of Ucp5 Enhances Mpp+-induced Neurotoxicity In Sh-sy5y Cells. , Mov Disorders. 2006, 20(10): 14.

 

Pawade T., Ho W.L., Kwok H.H., Chu A.C.Y., Ho S.L. and Ramsden D.B., Uncoupling Proteins: Targets Of Endocrine Disruptors?, In: I.T. Huhtaniemi, W.E. Rainey , R.J. Rodgers , Molecular and Cellular Endocrinology. Ireland, Elsevier, 2005, 244: 79-86.

 

Song Y., Ho W.L., Kwok H.H., Chu A.C.Y., Li Y. and Ho S.L., Genetic study of a large Chinese amyotrophic lateral sclerosis family., The 55th American society of Human Genetics meeting, October 25-29, 2005, Salt Lake City Utah, USA . 2005.

 

Researcher : Ho WM



List of Research Outputs

 

Ho W.L., Kwok H.H., Chu C.Y.A., Ho W.M., Kung M.H.W., Ramsden D.B. and Ho S.L., Silencing Of Ucp5 Enhances Mpp+-induced Neurotoxicity In Sh-sy5y Cells. , Mov Disorders. 2006, 20(10): 14.

 

Researcher : Hoo RLC



Project Title:

Role of adiponectin in mediating the therapeutic actions of the anti-diabetic drug thiazolidinediones

Investigator(s):

Hoo RLC, Xu A, Lam KSL

Department:

Medicine

Source(s) of Funding:

Small Project Funding

Start Date:

11/2005

 

Abstract:

Thiazolidinediones (TZDs), such as rosiglitazone and pioglitazone, are peroxisome-proliferator-activated receptor gamma (PPAR-gamma) agonists widely used in the treatment of type 2 diabetes. The cellular mechanism of action of TZDs involves binding to the PPAR-gamma, thus altering the expression of PPAR-gamma responsive gene in fat cells, as well as other cell types such as endothelial cells, macrophage, monocytes, vascular smooth cells (1,2). We and others have shown that they can reduce insulin resistance, hyperglycaemia, and endothelial dysfunction, an early change in atherosclerosis (3-6). However, the mechanism underlying the ability of PPAR-gamma agonists to improve in vivo hyperglycemia and insulin resistance is not well understood. Adipose tissue is now recognized as an important endocrine organ as it can secrete a variety of biologically active peptides such as adiponectin, plasminogen activated inhibitor I (PAI-1), resistin, leptin, TNF-alpha and IL-6. These adipokines are suggested to be critically involved in regulating systemic energy metabolism, insulin sensitivity, cardiovascular tone and immune response (6,7). Our group has been actively studying the regulation and function of adiponectin in recent years. We have shown that treatment with adiponectin can result in direct beneficial effects on insulin resistance, hyperglycaemia, dyslipidaemia and atherogenesis. Many pharmacological studies showed that TZDs, including rosiglitazone, can elevate the mRNA expression and plasma levels of adiponectin in animals and in patients with type 2 diabetes (10,11). However, whether adiponectin mediates the TZD's metabolic effects in T2DM and its related metabolic syndrome remains uncertain. Therefore, in the present study, we seek to investigate the mechanism of metabolic action of a potent TZD, rosiglitazone, in the presence or absence of adiponectin, by using a genetically modified mouse model that lacks both the adiponectin gene and leptin receptor. Major Objectives: The major aim of this study is to elucidate the involvement of adiponectin in the therapeutic function of the potent TZD, rosigltiazone, in the treatment of T2DM. The specific objectives are: 1. To knockout the adiponectin gene from the db/db diabetic mouse model. 2. To use the double knockout mice generated in Objective 1 to investigate whether adiponectin is required for the anti-diabetic action of rosiglitazone.

 

List of Research Outputs

 

Chen B., Lam K.S.L., Wang Y., Wu D., Lam C.W., Shen J., Wong L.C., Hoo R.L.C., Zhang J. and Xu A., Hypoxia dysregulates the production of adiponectin and plasminogen activator inhibitor-1 independent of reactive oxygen species in adipocytes, Biochem Biophys Res Commun. 2006, 341: 549-56.

 

Wang Y., Lam K.S.L., Chan L., Chan K.W., Lam J.B.B., Lam C.W., Hoo R.L.C., Mak W.W., Cooper G.J. and Xu A., Post-translational modifications of the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high molecular weight oligomeric complex, J Biol Chem. 2006, 281: 16391-400.

 

Wang Y., Lam K.S.L., Chan L., Chan K.W., Lam J.B.B., Lam C.W., Hoo R.L.C., Mak W.W., Cooper G.J.S. and Xu A., Posttranslational modifications on the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high-molecular-weight oligomeric complex, J Biol Chem. 2006.

 

Researcher : Hu HC



Project Title:

A study to validate a symptom severity questionnaire for patents with functional dyspepsia

Investigator(s):

Hu HC, Lam CLK

Department:

Medicine

Source(s) of Funding:

Health Services Research Fund - Full Grants

Start Date:

10/1998

 

Abstract:

To develop and validate an instrument to measure the severity of symptoms in patients with functional dyspepsia.

 

List of Research Outputs

 

Au W.Y., Cheung W.C., Hu H.C., Chan G.C.F., Ha S.Y., Khong P.L., Ma E.S.K. and Liang R.H.S., Hyperbilirubinaemia and cholelithiasis in Chinese patients with hemoglobin H disease., Annals of Hematology. 2005, 84(10): 671-674.

 

Chan O.O., Hui W.M., Chan C.K., Lai K.C., Hu H.C., Yuen R.M.F., Wong R.W.M., Lau G., Hui C.K., Lam S.K. and Wong B.C.Y., Colonoscopy Demand and Practice in a Regional Hospital over 9 Years in Hong Kong: Resource Implication for Cancer Screening, Gastroenterology. 2006, 130 (4 Suppl 2): A-618.

 

Chan O.O., Hui W.M., Chan C.K., Lai K.C., Hu H.C., Yuen R.M.F., Wong R.W.M., Lau G., Hui C.K., Lam S.K. and Wong B.C.Y., Colonoscopy demand and practice in a regional hospital over 9 years in Hong Kong: Resource implication for cancer screening, Digestion. 2006, 73(2-3): 84-88.

 

Chan O.O., Cheng C., Hui W.M., Hu H.C., Wong Y.H., Lam K.F., Wong R.W.M., Lai K.C., Lam S.K. and Wong B.C.Y., Differing coping mechanisms, stress level and anorectal physiology in patients with functional constipation, World Journal of Gastroenterology. The WJG Press and Elsevier Inc., 2005, 11(34): 5362-5366.

 

Chan O.O., Hui W.M., Hu H.C., Leung G., Chan C.K., Yuen R.M.F., Lam S.K. and Wong B.C.Y., Familial Aggregation in Constipated Subjects in a Tertiary Referral Center, Gastroenterology. 2006, 130 (4 Suppl 2): A-159.

 

Chan O.O., Jim M.H., Lam K.F., Siu D.C.W., Tong S.M., Ng F.H., Hui W.M., Chan C.K., Lai K.C., Hu H.C., Yuen R.M.F., Lau Y.K., Lee S.W.L., Lam S.K. and Wong B.C.Y., Patients with Coronary Artery Disease are at High Risk for Developing Colorectal Cancer and Adenoma: An Interim Analysis of a Prospective Study, Gastroenterology. 2006, 130 (4 Supp 2): A-36.

 

Chan O.O., Hui W.M., Lam K.F., Leung G., Hu H.C., Chan C.K., Yuen R.M.F., Lam S.K. and Wong B.C.Y., The Clinical Characteristics of Patients with Idiopathic Constipation with a Positive Family History, Gastroenterology. 2006, 130 (4 Suppl 2): A-158.

 

Chim J.C.S., Yuen W.K., Loong F., Hu H.C. and Ooi C.G.C., Primary large B-cell lymphoma of the ampulla of vater, Haematologica. 2006, 91(3): ECR06.

 

Lai K.C., Chu K.M., Hui W.M., Wong B.C.Y., Hu H.C., Wong W.M.R., Chan O.O.A., Wong J. and Lam S.K., Celecoxib compared with lansoprazole and naprosyn to prevent gastrointestinal ulcer complications, American Journal of Medicine. 2005, 118: 1271-1278.

 

Researcher : Hu R



List of Research Outputs

 

Hu R., Lee P.Y., Lau C.P. and Tse H.F., Impaired Nitrate-Medicated Dilatation Could Reflect Nitrate Tolerance and Predicted Need of Revascularization, JACC. 2006, 1000-159.

 

Hu R., Zhang X.X., Wang W.Q., Lau C.P. and Tse H.F., Smoking, homocysteine and degree of arteriolar retinopathy., Atherosclerosis . 2005, 183(1): 95-100.

 

Researcher : Hu R



List of Research Outputs

 

Hu R., Lee P.Y., Lau C.P. and Tse H.F., Impaired Nitrate-Medicated Dilatation Could Reflect Nitrate Tolerance and Predicted Need of Revascularization, JACC. 2006, 1000-159.

 

Hu R., Zhang X.X., Wang W.Q., Lau C.P. and Tse H.F., Smoking, homocysteine and degree of arteriolar retinopathy., Atherosclerosis . 2005, 183(1): 95-100.

 

Researcher : Huang FY



List of Research Outputs

 

Tang L.P., Cho C.H., Hui W.M., Huang F.Y., Lai C.L., Xia H.H.X., Lam S.K., Rashid A., Wong B.C.Y. and Chan O.O., A negative correlation between IL-6 and DNA methylation in patients with gastric cancer, Supplement to Gastroenterology - Digestive Disease Week and the 107th Annual Meeting of the American Gastroenterological Association Institute, May 20-25, 2006, Los Angeles, CA. 2006, 130:4 Suppl 2: A-717.

 

Researcher : Huang J



Project Title:

Hepatitis B or Hepatitis C viral infection and genotypes - which subgroup is more prone to the development of hepatocellular carcinoma? A systematic review

Investigator(s):

Huang J, Wong BCY, Lai CL, Yuen RMF

Department:

Clinical Trials Ctr

Source(s) of Funding:

Health and Health Services Research Fund - Full Grants

Start Date:

01/2004

 

Abstract:

To identify which subgroups of population infected with HBV/HCV are at higher risk for developing hepatocellular carcinoma (HCC).

 

Project Title:

Long-term use of non-steroidal anti-inflammatory drugs and development of colorectal tumours: a systematic review and meta-analysis

Investigator(s):

Huang J, Wong BCY

Department:

Clinical Trials Ctr

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

02/2004

Completion Date:

01/2006

 

Abstract:

To systematically and critically review the literature on the relationship between long-term use of NSAIDs and development of colorectal tumors, and to estimate the magnitude of protection on colorectal polyps and cancer in people taking long-term NSAIDs.

 

List of Research Outputs

 

Wang W., Huang J., Zheng G., Xia H.H.X., Wong R.W.M., Lam S.K. and Wong B.C.Y., Head-to-Head Comparison of H2-Receptor Antagonists and Proton Pump Inhibitors in the Treatment of Erosive Esophagitis: A Meta-Analysis, World Journal of Gastroenterology. 2005, 11(26): 4067-4077.

 

Researcher : Huang Q



Project Title:

Powerful and robust association studies of six positional and functional candidate genes with bone mass in Southern Chinese

Investigator(s):

Huang Q, Kung AWC

Department:

Medicine

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

01/2006

 

Abstract:

Background Osteoporosis is a skeletal disease characterized by low bone mineral density (BMD) and microarchitectural deterioration of bone tissue, with a consequent increase in bone fragility and susceptibility to fracture. The most common clinical outcomes of osteoporosis are fracture of the spine, hip and wrist. Of these, hip fractures are the most severe, leading to a 12-20% reduction of expected survival. The direct cost for hip fractures was around $13.8 billion in the US in 1995 (Ray et al. 1995), and £942 million in the UK in 1998 (Torgerson and Cooper, 1998). At present, osteoporosis affects 200,000 females and 100,000 males in Hong Kong. It is projected that by 2050, more than 50% of the world’s hip fractures will occur in Asia, mainly in China. It is well established that BMD and osteoporosis are under strong genetic control. However, identification of the genetic variants that cause osteoporosis still remains a daunting task for geneticists due to its genetic complexity [1]. Chromosomal regions 1p36, 12q23-24, and 20p12 are linked to osteoporosis in multiple genome-wide linkage studies [2-10]. CNR2, TNFR2, MTHFR, PLOD, IGF1, and BMP2 genes, which have demonstrated biological functional importance in bone metabolism, are located in these regions. Therefore, they are excellent positional and functional candidate genes for osteoporosis. However, whether or not they are associated with bone mass variation in Southern Chinese has not been established. Extensive regular association studies using a limited few markers have generated controversies for prominent candidate genes studied. The International Hapmap project has already been completed [11]. Screening multiple markers ulilizing this new resources is necessary for testing the significance of candidate genes systematically. In this project, we will conduct powerful and robust association studies of six positional and functional candidate genes and bone mass in Sourthern Chinese by using tag SNPs from the International Hapmap project. Objectives 1) To investigate whether genetic variability in six positional and functional candidate genes is associated with bone mass variation. 2) To determine the pattern of linkage disequilibrium, and estimate haplotype distribution at these genes in large Sourthern Chinese populations.

 

List of Research Outputs

 

Researcher : Hui CK



List of Research Outputs

 

Chan O.O., Hui W.M., Chan C.K., Lai K.C., Hu H.C., Yuen R.M.F., Wong R.W.M., Lau G., Hui C.K., Lam S.K. and Wong B.C.Y., Colonoscopy Demand and Practice in a Regional Hospital over 9 Years in Hong Kong: Resource Implication for Cancer Screening, Gastroenterology. 2006, 130 (4 Suppl 2): A-618.

 

Chan O.O., Hui W.M., Chan C.K., Lai K.C., Hu H.C., Yuen R.M.F., Wong R.W.M., Lau G., Hui C.K., Lam S.K. and Wong B.C.Y., Colonoscopy demand and practice in a regional hospital over 9 years in Hong Kong: Resource implication for cancer screening, Digestion. 2006, 73(2-3): 84-88.

 

Hui C.K., Lai L.S., Lam P., Zhang H., Fung T.T., Lai S.T., Wong W.M., Lo C.M., Fan S.T., Leung N. and Lau G., 48 weeks pegylated interferon alpha-2a is superior to 24 weeks of pegylated interferon alpha-2b in achieving hepatitis B e antigen seroconversion in chronic hepatitis B infection, Alimentary Pharmacology and Therapeutics. 2006, 23(8): 1171-1178.

 

Hui C.K., Lie A.K.W., Au W.Y., Leung A.Y.H., Ma S.Y., Cheung W.W., Zhang H., Chim J.C.S., Kwong Y.L., Liang R.H.S. and Lau G., A long-term follow-up study on hepatitis B surface antigen-positive patients undergoing allogeneic hematopoietic stem cell transplantation, Blood. 2005, 106(2): 464-9.

 

Hui C.K. and Lau G., Advances in immunomodulating therapy of HBV infection, International J Medical Sciences. 2005, 2: 24-29.

 

Hui C.K. and Lau G., Clevudine For Treatment Of Chronic Hepatitis B Virus Infection, Expert Opinion on Investigational Drugs. 2005, 14: 1277-1284.

 

Hui C.K. and Lau G., Clevudine for the treatment of chronic hepatitis B virus infection, Expert Opin Investig Drugs. 2005, 14(10): 1277-84.

 

Hui C.K., Bowden S., Zhang H., Wong A., Lewin S., Rousseau F., Mommeja-Marin H., Lee N.P., Luk J.M., Leung N., Naoumov N.V. and Lau G., Comparison of Real-Time PCR Assays for Monitoring serum HBV DNA levels during Antiviral Therapy, Journal of Clincial Microbiology. 2006, 44: 2983-2987.

 

Hui C.K. and Lau G., Current issues and future directions in treatment, Semin Liver Dis. 2006, 26(2): 192-7.

 

Hui C.K., Lau E., Kim M., Monto A., Luk J.M., Leung N., Lo C.M., Fan S.T., Wright T.L. and Lau G., Fibrosis Porgression in Patients with Recurrent Chronic Hepatitis C Virus and Occult Hepatitis B Co-Infection After Liver transplantation, J Gastroenterol and Hepatol. 2006, 21(2): A80.

 

Hui C.K., Lau E., Wu H., Monto A., Kim M., Luk J.M.C., Lau G. and Wright T.L., Fibrosis progression in chronic hepatitis C patients with occult hepatitis b co-infection, J Clin Virol . 2005, 35: 185-192.

 

Hui C.K., Lau E., Kim M., Monto A., Luk J.M.C., Leung N., Lo C.M., Fan S.T., Wright T.L. and Lau G., Fibrosis progression in patients with recurrent chronic hepatitis C virus and occult hepatitis B co-infection after liver transplantation (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A80.

 

Hui C.K., Cheung W., Au W.Y., Lie A.K.W., Zhang H., Yueng Y.H., Wong B.C.Y., Leung N., Kwong Y.L., Liang R.H.S. and Lau G., Hepatitis B reactivation after withdrawal of preemptive lamivudine in patients with hematological malignancy upon completion of cytotoxic chemotherapy, Liver International 2005. 2005, Oct: 182.

 

Hui C.K., Ma S.Y., Sun J., Au W.Y., Lie A.K.W., Chim J.C.S., Kwong Y.L., Liang R.H.S. and Lau G., Hepatitis B reactivation in patient with occult HBV infection after chemotherapy, J Hepatol. 2005, 42(6): 813-19.

 

Hui C.K. and Lau G., Immune system and hepatitis B virus infection, J Clin Virol. 2005, S44-8.

 

Hui C.K., Cheung W.W., Zhang H., Au W.Y., Yueng Y.H., Leung A.Y.H., Leung N., Luk J.M.C., Lie A.K.W., Kwong Y.L., Liang R.H.S. and Lau G., Kinetics and risk of de novo hepatitis B infection in HBsAg negative patients undergoing cytotoxic chemotherapy, Gastroenterology. 2006, 131: 59-68.

 

Hui C.K., Lau E., Monto A., Kim M., Luk J.M.C., Poon R.T.P., Leung N., Lo C.M., Fan S.T. and Lau G., Natural history of patients with recurrent chronic hepatitis C virus and occult hepatitis B co-infection after liver transplanation, AM J Transplanation. 2006, 6(7): 1600-8.

 

Hui C.K. and Lau G., Peginterferon-alpha2a (40kDa) (Pegasys) for hepatitis B, Expert Rev Anti Infect Ther. UK, Future Drugs, 2005, 3: 495-504.

 

Hui C.K., Cheung W.W., Zhang H., Au W.Y., Yueng Y.H., Leung A.Y.H., Leung N., Luk J.M.C., Lie A.K.W., Kwong Y.L., Liang R.H.S. and Lau G., Rituximab increases the Risk of De Novo hepatitis B infection in Hepatitis B Surface Antigen Negative Patients Undergoing Cytotoxic Chemotherapy, J Gastroenterol and Hepatol. 2006, 21(2): A73.

 

Hui C.K. and Lau G., The present and future therapy for chronic hepatitis B infection, Seminar in Liver Diseases (invited review). 2006, 26(2): 192-7.

 

Hui C.K., Bowden S., Lewin S., Locarnini S., Naoumov N.V. and Lau G., The use of Real-Time PCR Assays for Monitoring Hepatitis B Virus DNA Response ot Antiviral Therapy, J Clinical Microbiology. 2006, 44(8): 2983-7.

 

Hui C.K. and Lau G., Therapies for chronic hepatitis B virus infection, Hong Kong Pharmaceutical Journal. 2005, 14: 18-21.

 

Hui C.K., Zhan H.Y., Lee N.P., Yueng Y.H., Lu L., Leung N., Wong B.C., Lo C.M., Fan S.T., Luk J.M.C. and Lau G., Upregulation of toll-like receptor 7 is essential for serological clearance of hepatitis B surface antigen in chronic hepatitis B (HBV) infection, Hepatology. 2005, 42(4): 707A-708A, Suppl 1.

 

Hui C.K., Zhang H., Lee N.W., Lu L., Leung N., Wong B.C.Y., Lo C.M., Fan S.T., Luk J.M.C. and Lau G., Upregulation of toll-like receptor 7 is essential for serological clearance of hepatitis B surface antigen in chronic hepatitis B virus (HBV) infection, Liver International 2005. 2005, Oct: 196.

 

Lai L.S.W., Fung T.T., Lai S.T., Yiu J., Lam P., Zhang H., Wong W.M., Lo C.M., Fan S.T., Hui C.K., Leung N. and Lau G., 48 weeks pegylated interferon alfa-2a is superior to 24 weeks of pegylated interferon alfa-2b in achieving HBeAg seroconversion in chronic hepatitis B infection (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A90.

 

Lin M.C., Lee P.Y., Zheng N., Yang P., Wong O.G., Kung H.F., Hui C.K., Luk J.M.C. and Lau G., Tumor necrosis factor-a-induced protein 1 and immunity to hepatitis B virus, World Journal of Gastroenterology. 2005, 11(48): 7564-8.

 

Lu L., Hui C.K., Zhang H., Yueng Y.H., Cheung K.F. and Lau G., Quantification and Correlation of HBV DNA and RNA inPeripheral Blood Mononuclear Cells adn HBV DNA in Serum in Chronic Hepatitis B, J Gastroenterol and Hepatol. 2006, 21(2): A77.

 

Luk J.M.C., Chen L., Lam B.K.Y., Ho D.W.Y., Peng J.R., Leng X.S., Hui C.K., Lau G., Yip T.T. and Fan S.T., Comparing serum alpha-fetoprotein level and SELDI-TOF-MS profiling for diagnosis of hepatocellular carcinoma (Abstract), The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2-3 December 2005.

 

Luk J.M.C., Chen L., Lam B., Ho D., Peng J., Leng J., Leng X., Hui C.K., Lau G., Yip T.T. and Fan S.T., Comparing serum alpha-fetoprotein level and SELDI-TOF-MS profilling for diagnosis of hepatocellular carcinoma. The 4th JSH Single Topic conference on hepatocellular carcinoma. , Hoyogo, Japan. 2005, Dec2-3, 05.

 

Luk J.M.C., Wang X., Garcia-Barcelo M.M., Leung P.P., Lam B.K.Y., Ho D.W.Y., Yu W.C., Hui C.K. and Lau G., Genetic polymorphisms of liver intestine-cadherin CDH17 are associated with alternative mRNA splicing and increased risk of hepatocellular carcinoma (Abstract), Hepatology. 2005, 42(4): 307A-308A Suppl 1.

 

Xia B., Xia H.H.X., Ma C.W., Wong K.W., Fung F.M.Y., Hui C.K., Chan C.K., Chan O.O., Lai K.C., Yuen R.M.F. and Wong B.C.Y., Trends in the prevalence of peptic ulcer disease and Helicobacter pylori infection in family physician-referred uninvestigated dyspeptic patients in Hong Kong. , Alimentary Pharmacology and Therapeutics. 2005, 22(3): 243-9.

 

Zhang H., Hui C.K., Wong A., Lee N.P., Leung N., Luk J.M.C. and Lau G., Comparison of Real-Time PCR Assays for monitoring Serum HBV DNA Levels During Antiviral Therapy, J Gastroenterol and Hepatol. 2006, 21(2): A140.

 

Researcher : Hui CK



List of Research Outputs

 

Chan O.O., Hui W.M., Chan C.K., Lai K.C., Hu H.C., Yuen R.M.F., Wong R.W.M., Lau G., Hui C.K., Lam S.K. and Wong B.C.Y., Colonoscopy Demand and Practice in a Regional Hospital over 9 Years in Hong Kong: Resource Implication for Cancer Screening, Gastroenterology. 2006, 130 (4 Suppl 2): A-618.

 

Chan O.O., Hui W.M., Chan C.K., Lai K.C., Hu H.C., Yuen R.M.F., Wong R.W.M., Lau G., Hui C.K., Lam S.K. and Wong B.C.Y., Colonoscopy demand and practice in a regional hospital over 9 years in Hong Kong: Resource implication for cancer screening, Digestion. 2006, 73(2-3): 84-88.

 

Hui C.K., Lai L.S., Lam P., Zhang H., Fung T.T., Lai S.T., Wong W.M., Lo C.M., Fan S.T., Leung N. and Lau G., 48 weeks pegylated interferon alpha-2a is superior to 24 weeks of pegylated interferon alpha-2b in achieving hepatitis B e antigen seroconversion in chronic hepatitis B infection, Alimentary Pharmacology and Therapeutics. 2006, 23(8): 1171-1178.

 

Hui C.K., Lie A.K.W., Au W.Y., Leung A.Y.H., Ma S.Y., Cheung W.W., Zhang H., Chim J.C.S., Kwong Y.L., Liang R.H.S. and Lau G., A long-term follow-up study on hepatitis B surface antigen-positive patients undergoing allogeneic hematopoietic stem cell transplantation, Blood. 2005, 106(2): 464-9.

 

Hui C.K. and Lau G., Advances in immunomodulating therapy of HBV infection, International J Medical Sciences. 2005, 2: 24-29.

 

Hui C.K. and Lau G., Clevudine For Treatment Of Chronic Hepatitis B Virus Infection, Expert Opinion on Investigational Drugs. 2005, 14: 1277-1284.

 

Hui C.K. and Lau G., Clevudine for the treatment of chronic hepatitis B virus infection, Expert Opin Investig Drugs. 2005, 14(10): 1277-84.

 

Hui C.K., Bowden S., Zhang H., Wong A., Lewin S., Rousseau F., Mommeja-Marin H., Lee N.P., Luk J.M., Leung N., Naoumov N.V. and Lau G., Comparison of Real-Time PCR Assays for Monitoring serum HBV DNA levels during Antiviral Therapy, Journal of Clincial Microbiology. 2006, 44: 2983-2987.

 

Hui C.K. and Lau G., Current issues and future directions in treatment, Semin Liver Dis. 2006, 26(2): 192-7.

 

Hui C.K., Lau E., Kim M., Monto A., Luk J.M., Leung N., Lo C.M., Fan S.T., Wright T.L. and Lau G., Fibrosis Porgression in Patients with Recurrent Chronic Hepatitis C Virus and Occult Hepatitis B Co-Infection After Liver transplantation, J Gastroenterol and Hepatol. 2006, 21(2): A80.

 

Hui C.K., Lau E., Wu H., Monto A., Kim M., Luk J.M.C., Lau G. and Wright T.L., Fibrosis progression in chronic hepatitis C patients with occult hepatitis b co-infection, J Clin Virol . 2005, 35: 185-192.

 

Hui C.K., Lau E., Kim M., Monto A., Luk J.M.C., Leung N., Lo C.M., Fan S.T., Wright T.L. and Lau G., Fibrosis progression in patients with recurrent chronic hepatitis C virus and occult hepatitis B co-infection after liver transplantation (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A80.

 

Hui C.K., Cheung W., Au W.Y., Lie A.K.W., Zhang H., Yueng Y.H., Wong B.C.Y., Leung N., Kwong Y.L., Liang R.H.S. and Lau G., Hepatitis B reactivation after withdrawal of preemptive lamivudine in patients with hematological malignancy upon completion of cytotoxic chemotherapy, Liver International 2005. 2005, Oct: 182.

 

Hui C.K., Ma S.Y., Sun J., Au W.Y., Lie A.K.W., Chim J.C.S., Kwong Y.L., Liang R.H.S. and Lau G., Hepatitis B reactivation in patient with occult HBV infection after chemotherapy, J Hepatol. 2005, 42(6): 813-19.

 

Hui C.K. and Lau G., Immune system and hepatitis B virus infection, J Clin Virol. 2005, S44-8.

 

Hui C.K., Cheung W.W., Zhang H., Au W.Y., Yueng Y.H., Leung A.Y.H., Leung N., Luk J.M.C., Lie A.K.W., Kwong Y.L., Liang R.H.S. and Lau G., Kinetics and risk of de novo hepatitis B infection in HBsAg negative patients undergoing cytotoxic chemotherapy, Gastroenterology. 2006, 131: 59-68.

 

Hui C.K., Lau E., Monto A., Kim M., Luk J.M.C., Poon R.T.P., Leung N., Lo C.M., Fan S.T. and Lau G., Natural history of patients with recurrent chronic hepatitis C virus and occult hepatitis B co-infection after liver transplanation, AM J Transplanation. 2006, 6(7): 1600-8.

 

Hui C.K. and Lau G., Peginterferon-alpha2a (40kDa) (Pegasys) for hepatitis B, Expert Rev Anti Infect Ther. UK, Future Drugs, 2005, 3: 495-504.

 

Hui C.K., Cheung W.W., Zhang H., Au W.Y., Yueng Y.H., Leung A.Y.H., Leung N., Luk J.M.C., Lie A.K.W., Kwong Y.L., Liang R.H.S. and Lau G., Rituximab increases the Risk of De Novo hepatitis B infection in Hepatitis B Surface Antigen Negative Patients Undergoing Cytotoxic Chemotherapy, J Gastroenterol and Hepatol. 2006, 21(2): A73.

 

Hui C.K. and Lau G., The present and future therapy for chronic hepatitis B infection, Seminar in Liver Diseases (invited review). 2006, 26(2): 192-7.

 

Hui C.K., Bowden S., Lewin S., Locarnini S., Naoumov N.V. and Lau G., The use of Real-Time PCR Assays for Monitoring Hepatitis B Virus DNA Response ot Antiviral Therapy, J Clinical Microbiology. 2006, 44(8): 2983-7.

 

Hui C.K. and Lau G., Therapies for chronic hepatitis B virus infection, Hong Kong Pharmaceutical Journal. 2005, 14: 18-21.

 

Hui C.K., Zhan H.Y., Lee N.P., Yueng Y.H., Lu L., Leung N., Wong B.C., Lo C.M., Fan S.T., Luk J.M.C. and Lau G., Upregulation of toll-like receptor 7 is essential for serological clearance of hepatitis B surface antigen in chronic hepatitis B (HBV) infection, Hepatology. 2005, 42(4): 707A-708A, Suppl 1.

 

Hui C.K., Zhang H., Lee N.W., Lu L., Leung N., Wong B.C.Y., Lo C.M., Fan S.T., Luk J.M.C. and Lau G., Upregulation of toll-like receptor 7 is essential for serological clearance of hepatitis B surface antigen in chronic hepatitis B virus (HBV) infection, Liver International 2005. 2005, Oct: 196.

 

Lai L.S.W., Fung T.T., Lai S.T., Yiu J., Lam P., Zhang H., Wong W.M., Lo C.M., Fan S.T., Hui C.K., Leung N. and Lau G., 48 weeks pegylated interferon alfa-2a is superior to 24 weeks of pegylated interferon alfa-2b in achieving HBeAg seroconversion in chronic hepatitis B infection (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A90.

 

Lin M.C., Lee P.Y., Zheng N., Yang P., Wong O.G., Kung H.F., Hui C.K., Luk J.M.C. and Lau G., Tumor necrosis factor-a-induced protein 1 and immunity to hepatitis B virus, World Journal of Gastroenterology. 2005, 11(48): 7564-8.

 

Lu L., Hui C.K., Zhang H., Yueng Y.H., Cheung K.F. and Lau G., Quantification and Correlation of HBV DNA and RNA inPeripheral Blood Mononuclear Cells adn HBV DNA in Serum in Chronic Hepatitis B, J Gastroenterol and Hepatol. 2006, 21(2): A77.

 

Luk J.M.C., Chen L., Lam B.K.Y., Ho D.W.Y., Peng J.R., Leng X.S., Hui C.K., Lau G., Yip T.T. and Fan S.T., Comparing serum alpha-fetoprotein level and SELDI-TOF-MS profiling for diagnosis of hepatocellular carcinoma (Abstract), The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2-3 December 2005.

 

Luk J.M.C., Chen L., Lam B., Ho D., Peng J., Leng J., Leng X., Hui C.K., Lau G., Yip T.T. and Fan S.T., Comparing serum alpha-fetoprotein level and SELDI-TOF-MS profilling for diagnosis of hepatocellular carcinoma. The 4th JSH Single Topic conference on hepatocellular carcinoma. , Hoyogo, Japan. 2005, Dec2-3, 05.

 

Luk J.M.C., Wang X., Garcia-Barcelo M.M., Leung P.P., Lam B.K.Y., Ho D.W.Y., Yu W.C., Hui C.K. and Lau G., Genetic polymorphisms of liver intestine-cadherin CDH17 are associated with alternative mRNA splicing and increased risk of hepatocellular carcinoma (Abstract), Hepatology. 2005, 42(4): 307A-308A Suppl 1.

 

Xia B., Xia H.H.X., Ma C.W., Wong K.W., Fung F.M.Y., Hui C.K., Chan C.K., Chan O.O., Lai K.C., Yuen R.M.F. and Wong B.C.Y., Trends in the prevalence of peptic ulcer disease and Helicobacter pylori infection in family physician-referred uninvestigated dyspeptic patients in Hong Kong. , Alimentary Pharmacology and Therapeutics. 2005, 22(3): 243-9.

 

Zhang H., Hui C.K., Wong A., Lee N.P., Leung N., Luk J.M.C. and Lau G., Comparison of Real-Time PCR Assays for monitoring Serum HBV DNA Levels During Antiviral Therapy, J Gastroenterol and Hepatol. 2006, 21(2): A140.

 

Researcher : Hui WM



List of Research Outputs

 

Chan O.O., Hui W.M., Chan C.K., Lai K.C., Hu H.C., Yuen R.M.F., Wong R.W.M., Lau G., Hui C.K., Lam S.K. and Wong B.C.Y., Colonoscopy Demand and Practice in a Regional Hospital over 9 Years in Hong Kong: Resource Implication for Cancer Screening, Gastroenterology. 2006, 130 (4 Suppl 2): A-618.

 

Chan O.O., Hui W.M., Chan C.K., Lai K.C., Hu H.C., Yuen R.M.F., Wong R.W.M., Lau G., Hui C.K., Lam S.K. and Wong B.C.Y., Colonoscopy demand and practice in a regional hospital over 9 years in Hong Kong: Resource implication for cancer screening, Digestion. 2006, 73(2-3): 84-88.

 

Chan O.O., Cheng C., Hui W.M., Hu H.C., Wong Y.H., Lam K.F., Wong R.W.M., Lai K.C., Lam S.K. and Wong B.C.Y., Differing coping mechanisms, stress level and anorectal physiology in patients with functional constipation, World Journal of Gastroenterology. The WJG Press and Elsevier Inc., 2005, 11(34): 5362-5366.

 

Chan O.O., Hui W.M., Hu H.C., Leung G., Chan C.K., Yuen R.M.F., Lam S.K. and Wong B.C.Y., Familial Aggregation in Constipated Subjects in a Tertiary Referral Center, Gastroenterology. 2006, 130 (4 Suppl 2): A-159.

 

Chan O.O., Chu K.M., Leung S.Y., Huang C., Sun Y.W., Ko S., Yuen R.M.F., Xia H.H.X., Cho C.H., Hui W.M., Lam S.K., Rashid A. and Wong B.C.Y., Helicobacter pylori infection, interleukin 1 beta polymorphism and predisposition to gastric cancer through the CpG island methylation pathway, Presented at 11th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong, 14 January 2006.

 

Chan O.O., Jim M.H., Lam K.F., Siu D.C.W., Tong S.M., Ng F.H., Hui W.M., Chan C.K., Lai K.C., Hu H.C., Yuen R.M.F., Lau Y.K., Lee S.W.L., Lam S.K. and Wong B.C.Y., Patients with Coronary Artery Disease are at High Risk for Developing Colorectal Cancer and Adenoma: An Interim Analysis of a Prospective Study, Gastroenterology. 2006, 130 (4 Supp 2): A-36.

 

Chan O.O., Hui W.M., Lam K.F., Leung G., Hu H.C., Chan C.K., Yuen R.M.F., Lam S.K. and Wong B.C.Y., The Clinical Characteristics of Patients with Idiopathic Constipation with a Positive Family History, Gastroenterology. 2006, 130 (4 Suppl 2): A-158.

 

Chan O.O., Chu K.M., Sun Y.W., Cheung H.K.L., Lam S.K., Yuen R.M.F., Hui W.M. and Wong B.C.Y., The association between interleukin 1 beta polymorphism and hypermethylation at tumor suppressor genes in gastric cancer. , Gastroenterology. 2005, 128 (Suppl 2): 1399-400.

 

Chan O.O., Lam K.F., Hui W.M., Hu W.H., Li J., Lai K.C., Chan C.K., Yuen R.M.F., Lam S.K. and Wong B.C.Y., Validated questionnaire on diagnosis and symptom severity for functional constipation in the Chinese population, Alimentary Pharmacology and Therapeutics. Blackwell Publishing Ltd, 2005, 22: 483-488.

 

Chan O.O., Chu K.M., Leung S.Y., Huang C., Sun Y., Ko S., Yuen R.M.F., Xia H.H.X., Cho C.H., Hui W.M., Lam S.K., Rashid A. and Wong B.C.Y., Helicobacter pylori Infection, Interleukin 1 Beta Polymorphism and Predisposition to Gastric Cancer Through the Cpg Island Methylation, Gastroenterology. 2006, 130 (4 Suppl 2): A-717.

 

Lai K.C., Chu K.M., Hui W.M., Wong B.C.Y., Hu H.C., Wong W.M.R., Chan O.O.A., Wong J. and Lam S.K., Celecoxib compared with lansoprazole and naprosyn to prevent gastrointestinal ulcer complications, American Journal of Medicine. 2005, 118: 1271-1278.

 

Wong B.C.Y., Chan O.O., Wong R.W.M., Hui W.M., Kung H. and Lam S.K., Attitudes and knowledge of colorectal cancer and screening in Hong Kong – A population-based study, Journal of Gastroenterology and Hepatology. 2006, 21(1 Pt 1): 41-46.

 

Researcher : Hui WS



List of Research Outputs

 

Mak J.C.W., Hui W.S., Ho S.P., So W.H.L., Chan M.M.W., Cho C.H. and Lam W.K., Inducation of CINC-1 in the lung tissue from rats exposed to cigarette smoke, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2006, Abstract Book 088: pp. 55.

 

Mak J.C.W., Hui W.S., Ho S.P., So W.H., Chan M.M.W., Cho C.H. and Lam W.K., Induction of CINC-1 in the lung tissue from rats exposed to cigarette smoke, American Journal of Respiratory and Critical Care Medicine. 2006, 173(3): A634.

 

Mak J.C.W., Hui W.S., Tipoe G.L., Lam W.K. and Tsang K.W.T., Regulation of cytokine- and phorbol ester-mediated interleukin (IL)-8 expression in the absence of presence of pyocyanin in human bronchial epithelial cell line: roles of protein kinase C and mitogen-activated protein kinases, European Respiratory Journal. 2005, 26 (Suppl 49): 99S (#709).

 

Pan N.Y., Hui W.S., Tipoe G.L., Lam W.K., Tsang K.W.T. and Mak J.C.W., Effects of glucocorticosteroids and antimicrobial drugs on inhibition of IL-1-beta and PDBu-induced IL-8 release in the presence of pyocyanin in bronchial epithelial cell line, European Respiratory Journal. 2005, 26(Suppl 49): 99s.

 

Researcher : Ip MSM



Project Title:

The efficacy of the modified oral appliance in the treatment of mild and moderate obstructive Sleep Apnoea

Investigator(s):

Ip MSM

Department:

Medicine

Source(s) of Funding:

Other Funding Scheme

Start Date:

02/1997

 

Abstract:

To assess the efficacy, side effects and patient acceptance of an oral appliance in the treatment of obstructive sleep apnoea; to define the clinical, anthropometric, polysomnographic and cephalometric characteristics that determine treatment response.

 

Project Title:

The effect of oral appliance (OA) in treatment of obstructive sleep apnoea

Investigator(s):

Ip MSM, Peh WCG, Cooke MS, Kim S.

Department:

Medicine

Source(s) of Funding:

Other Funding Scheme

Start Date:

06/1997

 

Abstract:

To study the efficacy of OA in teatment of mild/moderate OSA; to study the safety profile of OA.

 

Project Title:

Role of adiponectin in obstructive sleep apnoea

Investigator(s):

Ip MSM, Lam KSL, Lam J.

Department:

Medicine

Source(s) of Funding:

Small Project Funding

Start Date:

11/2002

 

Abstract:

To investigate serum adiponectin levels in OSA patients with a spectrum of body mass index (BMI) and sleep disordered breathing (no OSA to severe OSA) and define correlative parameters; to investigate for any difference in adiponectin levels in patients with OSA and BMI-matched subjects with no OSA (3) the impact of nasal Continuous Positive Airway pressure (nCPAP) treatment on adiponectin secretion in subjects with OSA.

 

Project Title:

Candidate genes of obstructive sleep apnoea syndrome in Hong Kong Chinese

Investigator(s):

Ip MSM, Lam KSL, Song Y, Sham PC, Lam CL

Department:

Medicine

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

01/2005

 

Abstract:

The main objectives of this project are: 1) To study the presence and role of genetic polymorphism of selected candidate genes relating to the obesity phenotypes in the OSA patients in Hong Kong 2) As an initiating project, to provide pilot data on the role of genetic changes in selected candidate genes in Chinese OSA patients, and to prepare for future in-depth studies in family cohorts

 

List of Research Outputs

 

Chan C.H., Ip M.S.M. and Shum D.K.Y., Heparan Sulfate/Syndecan-1 Modulates the Balance between Proteinase and Anti-Proteinase in Bronchiectasis, Proteoglycans in Signaling Stockholm (Runo), Sweden, September 7-11,2005.

 

Chow W.S., Tan K.C.B., Lam J.C.M., Lam B., Bucala R., Betteridge D.J. and Ip M.S.M., Advanced glycation end products are increased in non-diabetic patients with obstructive sleep apnea but to a lesser degree than type 2 diabetic patients, 11th Medical Research Conference of Department of Medicine, HKU. 2006.

 

Ho J.C.M., Mak J.C.W., Ho S., Ip M.S.M., Tsang K.W.T., Lam W.K. and Chan M.M.W., Manganese superoxide dismutase and catalase genetic polymorphisms, activity levels and lung cancer risk in Chinese in Hong Kong. 11th World Conference on Lung Cancer , Lung Cancer. 2005, 49(Suppl 2): S191.

 

Hou H.M., Sam K., Hagg E.U.O., Rabie A.B.M., Bendeus S.A.M., Yam L.Y.C. and Ip M.S.M., Long-term dento-facial changes in Chinese OSA patients following treatment with a mandibular advancement device, The Angle Orthodontist. 2006, 76: 432-440.

 

Ip M.S.M., Adopokines and sleep related breathing disorders, World Federation of Sleep Research & Sleep Medicine Societies Second Interim Congress, New Delhi, India, September . 2005.

 

Ip M.S.M. and Lam J.C.M., American Thoracic Society International Trainee Travel Award, American Thoracic Society 2006, San Diego, USA. 2006.

 

Ip M.S.M., COPD epidemiology : Asia-Pacific perspective , Annual Scientific Meeting, Hong Kong Thoracic Society and American College of Chest Physicians, November,. 2005.

 

Ip M.S.M., Cardiovascular complications of sleep apnoea, Hong Kong Allergy Convention, August 2005. 2005.

 

Ip M.S.M., Chairman, Free Paper Session (Clinical Curriculum), 3rd Congress of Asian Medical Education Association, Seoul, Korea, October 2005. 2005.

 

Ip M.S.M., Current understanding in sleep apnea, "Update on Respiratory Medicine", Hong Kong College of Family Physicians Annual Seminar, November 2005. 2005.

 

Ip M.S.M., Facilitator, Workshop on "What makes a good medical school", Institute of Medical and Health Sciences Education (IMHSE), Faculty of Medicine, The University of Hong Kong, May. 2006.

 

Ip M.S.M., Facilitator, Workshop on Curriculum and Programme Management, Institute of Medical and Health Sciences Education (IMHSE), Faculty of Medicine, The University of Hong Kong, November. 2005.

 

Ip M.S.M., Insulin resistance, fat and obstructive sleep apnea, American Thoracic Society Conference 2006, San Diego, USA, May, 2006. 2006.

 

Ip M.S.M., Management of obstructive sleep apnoea - why and how?, Annual Chest Convention, Philippine College of Chest Physicians, Manila, Philippine, February 2006. 2006.

 

Ip M.S.M., Ko F.W., Lau C.W., Yu W.C., Choo K., Tang K.S. and Chan M.M.W., Update reference values of spirometry for adult Chinese in Hong Kong and implications on clinical ulilisation, Chest. 2006, 129: 384-392.

 

Kwong Y.L., Lau W.C.S., Ho S.L., Epstein R., Young R.T.T., Chan H.H.L., Tse H.F., Lam L., Chen W.H., Lee K.L.F., Ip M.S.M., Tsang K.W.T., Lam B., Tang S.C.W., Chan R.H.W., Lee S.W.L., Tan K.C.B., Yeung C.K., Chan D.T.M., Wong R.W.S., Choy C.B.Y., Wong B.C.Y., Li F.K., Lo W.K., Lui S.L., Cheung R.T.F., Mak W., Ho J.C.M., Mok T.M.Y., Kung A.W.C., Cheung B.M.Y., Chow W.S., Yuen R.M.F. and Wat N.M.S., In: Lau CP, Kumana CR, Lai CL, Lai KN, Lam KSL, Lam WK, Problem-Based Medical Case Management. Hong Kong, Hong Kong University Press, 2005.

 

Lam B., Tam C.M., Lam S.Y., Wong M.P., Ooi C.G.C., Fung S.L., Lam D.C.L., Ip M.S.M. and Lam W.K., Detection of early lung cancer in high risk population: A prospective study. 11th World Conference on Lung Cancer, Lung Cancer. 2005, 49 (Suppl 2): S182 (P-257).

 

Lam B., Wong M.P., Fung S.L., Lam D.C.L., Wong P.C., Mok T.Y.W., Lam F.M., Ip M.S.M., Ooi C.G.C. and Lam W.K., The clinical value of autofluorescence bronchoscopy for the diagnosis of lung cancer, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2006, Abstract Book 094: pp. 58.

 

Lam J.C.M., Lam B., Tang S.C.W. and Ip M.S.M., A sleep study with positional hypoxemia, Sleep Medicine. 2006, 7: 383-384.

 

Lam J.C.M., Lam B., Lam C.L., Fong D.Y.T., Wang J., Tse H.F., Lam K.S.L. and Ip M.S.M., Obstructive sleep apnoea and the metabolic syndrome in community based Chinese adults in Hong Kong, Respiratory Medicine. 2006, 100: 980-987.

 

Lam J.C.M., Lam B., Lam C.L.K., Fong D.Y.T., Wang J.K.L., Tse H.F., Lam K.S.L. and Ip M.S.M., Obstructive sleep apnoea and the metabolic syndrome in community-based, Chinese Adults in Hong Kong Resp Med . 2006, 100: 980-987.

 

Mak J.C.W., Leung C.M., Ho S.P., Law K.W., Ho A.S.S., Lam W.K., Ip M.S.M. and Chan M.M.W., Analysis of transforming growth factor-beta(1) gene polymorphisms in Hong Kong Chinese asthmatic patients, Journal of Allergy and Clinical Immunology. 2006, 117: 92-96.

 

Mak J.C.W., Leung C.M., Ho S.P., Law K.W., Tsang K.W.T., Lam W.K., Ip M.S.M. and Chan M.M.W., Best Poster - Genetic Susceptibility Of Transforming Growth Factor-beta1 Common Polymorphisms To Chinese Patients With Asthma, Hong Kong Allergy Convention 2005 . 2005.

 

Mak J.C.W., Ho S.P., Leung Y.H., Ho P.L., Ooi C.G.C., Tipoe G.L., Yan C.P.K., Ip M.S.M., Lam W.K. and Tsang K.W.T., Elevated levels of transforming growth factor-beta(1) in serum of patients with stable bronchiectasis, Respiratory Medicine. 2005, 99: 1223-1228.

 

Mak J.C.W., Leung C.M., Ho S.P., Law K.W., Tsang K.W.T., Lam W.K., Ip M.S.M. and Chan M.M.W., Genetic susceptibility of transforming growth factor-beta(1) common polymorphisms to Chinese patients with asthma, Hong Kong Allergy Convention, Hong Kong. 2005, Abstract AB25: p.54.

 

Mak J.C.W., Ho S.P., Leung C.M., Lam W.K., Ip M.S.M. and Chan M.M.W., Genetic susceptibility to chronic obstructive pulmonary disease (COPD) : Transforming growth factor-beta common polymorphisms and plasma levels, American Journal of Respiratory and Critical Care Medicine. 2006, 173(3): A624.

 

Mak J.C.W., Ho S.P., Leung C.M., Lam W.K., Ip M.S.M. and Chan M.M.W., Genetic susceptibility to chronic obstructive pulmonary disease (COPD) : transforming growth factor-beta(1) common polymorphisms and plasma levels, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong, January 2006. Abstract Book 089: pp.56.

 

Mak J.C.W., Leung C.M., Ho S.P., Ko F.W.S., Cheung A.H.K., Ip M.S.M. and Chan M.M.W., Polymorphisms in manganese superoxide dismutase and catalase genes - functional study in Hong Kong Chinese asthma patients , Clinical and Experimental Allergy. 2006, 36: 440-447.

 

Mak J.C.W., Ho J.C.M., Ho S.P., Leung C.M., Law K.W., Lam W.K., Ip M.S.M. and Chan M.M.W., Polymorphisms in superoxide dismutase (SOD) and catalase genes - functional study in Chinese patients with asthma, Hong Kong Allergy Convention, Hong Kong. 2005, Abstract AB26: p.54.

 

Mak J.C.W., Ho S.P., Wong M.P., Tsang K.W.T., Ip M.S.M., Lam W.K. and Chan M.M.W., Transforming growth factor (TGF)-b[sub]1[/sub] gene common polymorphisms and plasma TGF-b[sub]1[/sub] levels in patients with lung cancer, European Respiratory Journal. 2005, 26 (Suppl 49): 435S (#2797).

 

Sam K., Lam B., Ooi C.G.C., Cooke M.S. and Ip M.S.M., Effect of a fixed oral appliance on upper airway morphology in obstructive sleep apnea, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong, January 2006. Abstract Book 095: pp.59.

 

Sam K., Lam B., Ooi C.G.C., Cooke M.S. and Ip M.S.M., Effect of a non-adjustable oral appliance on upper airway morphology in obstructive sleep apnea, Respiratory Medicine. 2006, 100: 897-902.

 

Tan K.C.B., Chow W.S., Lam J.C.M., Lam B., Bucala R., Betteridge D.J. and Ip M.S.M., Advanced glycation end products are increased in non-diabetic patients with obstructive sleep apnea but to a lesser degree than type 2 diabetic patients, 41st European Association for the Study of Diabetes Annual Meeting, Athens, Sept 2005.

 

Tan K.C.B., Chow W.S., Lam J.C.M., Lam B., Bucala R., Betteridge D.J. and Ip M.S.M., Advanced glycation end products in non-diabetic patients with obstructive sleep apnea, Sleep . 2006, 29: 329-33.

 

Tan K.C.B., Chow W.S., Lam J.C.M., Lam B., Wong W.K., Tam S. and Ip M.S.M., HDL dysfunction in obstructive sleep apnea, Atherosclerosis. 2006, 184(2): 377-82.

 

Tang S.C.W., Lam B., Leung H., Ip M.S.M. and Lai K.N., Impact of nocturnal peritoneal dialysis on the severity of sleep apnoea and the duration of hypoxemia during sleep: A cross-over study, Journal of American Society of Nephrology. 2005, 16: 852A.

 

Wang J., Ho J.C.M., Lam W.K., Ip M.S.M., Chan M.M.W. and Tsang K.W.T., Lymphoepithelioma-like-carcinoma of the lung : experience with 13 cases, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2006, Abstract Book 104: pp. 59.

 

Wong M., Yasufuku K., Nakajima T., Motohashi S., Iyoda A., Suzuki M., Sekine Y., Shibuya K., Iizasa T., Hiroshima K., Tsang K.W.T., Ip M.S.M., Lam W.K. and Fujisawa T., Endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA) in the diagnosis of sarcoidosis, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2006, Abstract Book 092: pp. 57.

 

Yiu K.H., Miu R., Lee K.L.F., Yung L.Y., Siu C.W.D., Tse H.F., Lam B., Lam J., Ip M.S.M. and Lau C.P., Improvement of sleep Apnea in heart failure patients after cardiac resynchronization therapy is associated with a significant dop in pulmonary arterial pressure, Heart Rhythm. 2006, 3, No. 5: S87.

 

Yiu K.H., Lee K.L.F., Tse H.F., Siu C.W.D., Lam B., Ip M.S.M. and Lau C.P., Improvement of sleep apnea in heart failure patients after cardiac resynchronization therapy is caused by relief of pulmonary congestion as reflected by a drop of pulmonary arterial pressure, Europace. 2006, 10/6.

 

Yiu K.H., Miu K.M., Lee K.L.F., Tse H.F., Siu C.W.D., Lam K., Lam B., Ip M.S.M. and Lau C.P., Improvement of sleep apnea in heart failure patients after cardiac resynchronization therapy is caused by relief of pulmonary congestion sa reflected by a drop of pulmonary congestion as reflected by a drop of pulmonary arterial pressure, Europace . 2006, 8 Supplement 1: 10/6.

 

Zielinski J., Bedarek M., Gorecka D., Viegi G., Hurd S.S., Fukuchi Y., Lai C.K.W., Ran P.X., Ko F.W.S., Liu S.M., Zhang J.P., Zhong N.S., Ip M.S.M. and Vermeire P.A., Increasing COPD awareness, European Respiratory Journal. 2006, 27: 833-852.

 

Researcher : Jiang X



List of Research Outputs

 

Fan X.M., Jiang X., Gu Q., Ching Y.P., He H., Xia H.H.X., Lin M.C., Chan O.O., Yuen R.M.F., Kung H.F. and Wong B.C.Y., Inhibition of Akt/PKB by a COX-2 Inhibitor Induces Apoptosis in Gastric Cancer Cells, Digestion. 2006, 73(2-3): 75-83.

 

Researcher : Jiang Y



List of Research Outputs

 

Jiang Y., Xia B., Jiang L., Lv M., Guo Q., Chen M., Li J., Xia H.H.X. and Wong B.C.Y., Association of CTLA-4 gene microsatellite polymorphism with ulcerative colitis in Chinese patients., Inflammatory bowel disease. 2006, 12(5): 369-373.

 

Researcher : Jim MH



List of Research Outputs

 

Siu C.W.D., Jim M.H., Tse H.F., Fan K., Chau M.C. and Chow W.H., Comparison of the efficacy and safety profiles fo intravenuous vitamin K and fresh frozen plasma as treatment of warfarin-related over-anticoagulation in patients with mechanical heart valves, Am J Cardiol. 2006, 97(3): 409-11.

 

Siu C.W.D., Jim M.H., Kung A.W.C., Lau C.P. and Tse H.F., The Outcomes of Thyrotoxicosis Related New-Onset Atrial Fibrillation, JACC. 2006, 47: 10A.

 

Researcher : Jin C



List of Research Outputs

 

Zhang H., Jin Y., Chen X., Jin C., Law S.Y.K., Tsao G.S.W. and Kwong Y.L., Cytogenetic aberrations in immortalization of esophageal epithelial cells, Cancer Genetics and Cytogenetics. 2006, 165(1): 25-35.

 

Researcher : Jin L



List of Research Outputs

 

Lau H.L., Ng M.Y.M., Jin L., Paterson A., Sham P.C., Luk K.D.K., Chan V.N.Y. and Kung A.W.C., Test of linkage and association of 14 genetic loci with bone size, 27th Annual Meeting of the American Society for Bone & Mineral Research, 23-27 September 2005, Nashville, USA. 2005.

 

Researcher : Jin Y



Project Title:

Cytogenetic and molecular genetic characterization of esophageal carcinomas

Investigator(s):

Jin Y, Kwong YL, Tsao GSW

Department:

Medicine

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

10/2002

 

Abstract:

To identify, by cytogenetic, fluorescence in situ hybridization (FISH), and molecular genetic approaches, the genetic changes that are important in the malignant transformation of esophageal epithelium; to investigate genetic differences and similarity between immortalized, preneoplastic esophageal epithelial cells and aquamous cell carcinoma (SCC) of the esophagus.

 

List of Research Outputs

 

Jin Y., Feng H., Deng W., Zhang H., Lu M., Jin C., Tsao G.S.W. and Kwong Y.L., Immortalization of human extravillous cytotrophoblasts by human papilloma virus gene E6E7: sequential cytogenetic and molecular genetic characterization, Cancer Genetics and Cytogenetics. 2005, 163: 30-37.

 

Li H.M., Man C.W.Y., Jin Y., Deng W., Yip Y.L., Feng H., Cheung Y.C., Lo K.W., Meltzer P.S., Wu Z.G., Kwong Y.L., Yuen P.W. and Tsao G.S.W., Molecular and cytogenetic changes involved in the immortalization of nasopharyngeal epithelial cells by telomerase, International Journal of Cancer. 2006, 119: 1567-1576.

 

Zhang H., Jin Y., Chen X., Jin C., Law S.Y.K., Tsao G.S.W. and Kwong Y.L., Cytogenetic aberrations in immortalization of esophageal epithelial cells, Cancer Genetics and Cytogenetics. 2006, 165(1): 25-35.

 

Researcher : Ko CF



List of Research Outputs

 

Ho P.L., Chau P.H., Yip P.S.F., Ooi C.G.C., Khong P.L., Ho J.C.M., Wong P.C., Ko C.F., Yan C.P.K. and Tsang K.W.T., A prediction rule for clinical diagnosis of severe acute respiratory syndrome, European Respiratory Journal. 2005, 26(3): 474-9.

 

Researcher : Ko KW



List of Research Outputs

 

Kwok R.P., Leung Y.H., Sun J.Z., Yan C.P.K., Ko K.W., Ooi C.G.C., Ho P.L., Tipoe G.L., Lam W.K. and Tsang K.W.T., The effects of myrtol standardized on human ciliary beat frequency in vitro, European Respiratory Medicine. 2005, 26 (Suppl 49): 100S (#714).

 

Researcher : Kumana CR



List of Research Outputs

 

Au W.Y., Kumana C.R., Lam C.W., Cheng V.C.C., Shek T.W.H., Chan E.Y.T., Liu K.Y. and Kwong Y.L., Solid tumors subsequent to arsenic trioxide treatment for acute promyelocytic leukemia, Leukemia Research. 2006.

 

Cheung B.M.Y., Manil Y.B., Tse H.F., Kumana C.R. and Lau C.P., Advantages of blood pressure optimization, Adv Ther. 2005, 22(4): 285-96.

 

Cheung B.M.Y., Chau J., McGhee S.M., Lauder I.J., Lau C.P. and Kumana C.R., Cost-effectiveness of Statins for Coronary Heart Disease Patients with Hypercholesterolaemia, Hong Kong Medical Journal. China, Scientific Communications International, Ltd., 2006, 12(2) Supplement: 20-23.

 

Cheung B.M.Y., Cheung G.T.Y., Lauder I.J., Lau C.P. and Kumana C.R., Meta-analysis of Large Outcome Trials of Angiotensin Receptor Blockers in Hypertension, Journal of Human Hypertension. 2006, 20(1): 37-43.

 

Kumana C.R. and Kay R., Medical professionalism in a changing SAR., Hong Kong Medical Journal. 2006, 12(3): 172-3.

 

Kumana C.R., Cheung B.M.Y., Cheung G.T.Y., Ovedal T. and Pederson B., Rhythm vs rate control of atrial fibrillation meta-analysed by number needed to treat., Br J clin Pharmacol. 2005, 60(4): 347-54.

 

Kwong Y.L., Chow C., Kumana C.R., Srivastava G. and Au W.Y., Arsenic trioxide in mantle cell lymphoma, Blood (American Society of Hematology 2005 Annual Meeting Abstracts) . 2005, 106 (11): 283B-284B 4814 Part 2 Nov 16 2005.

 

Li Y.Y., Cheung B.M.Y., Wong L.Y.F., Hwang I.S.S., Kumana C.R. and Tang F., Adrenomedullin gene expression and levels in the cardiovascular system after treatment with lipopolysaccharide, Neuropeptides. 2005, 39: 73-80.

 

Researcher : Kung AWC



Project Title:

Evaluation of maternal and fetal modulators in the development of postpartum autoimmune thyroiditis in a murine model of experimental autoimmune thyroiditis induced by thyroid peroxidase

Investigator(s):

Kung AWC, Banga J.P.

Department:

Medicine

Source(s) of Funding:

Small Project Funding

Start Date:

11/2003

 

Abstract:

To determine the incidence of pregnancy outcome in a murine model of AITD induced by immunizing C57B/6(H2[b]) mice with homologous mouse TPO, and to determine the pathogenicity of anti-TPO Ab against placental and fetal antigen; to determine the severity of postpartum thyroiditis in allogeneic C57B/6(H2[b]) x CBA/J(H2[d]) versus synergeneic C57B/6(H2[b]) x C57B/6(H2[b]) and CBA/J(H2[d]) x CBA/J(H2[d]) animals; to determine the cytokine profile in the above animals during pregnancy and postpartum period

 

Project Title:

An association screen for osteoporosis susceptibility loci in chromosome 3p

Investigator(s):

Kung AWC, Sham PC, Chan VNY

Department:

Medicine

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

Completion Date:

10/2006

 

Abstract:

To identify novel susceptible loci for osteoporosis using BMD as a quantitative trait by conducting a high-density SNP screen in the gene-rich zone of chromosome 3p.

 

Project Title:

To discover new genes in chromosome 14q11-32 for the determination of osteoporosis and boen mineral density

Investigator(s):

Kung AWC

Department:

Medicine

Source(s) of Funding:

Merit Award for RGC CERG Funded Projects

Start Date:

08/2005

 

Abstract:

N/A

 

Project Title:

To discover new genes in chromosome 14q11-32 for the determination of osteoporosis and boen mineral density

Investigator(s):

Kung AWC, Luk KDK, Chan VNY, Paterson A, Sham PC

Department:

Medicine

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

08/2005

 

Abstract:

Phase I: to determine the linkage and association of markers in the chromosomal region 14q11-32 with bone mineral density (BMD) at the spine and hip using two approaches: (1) linkage analysis by multipoint allele-sharing methods in 250 extended southern Chinese families. (2) case-control association study using haploytpe-tagging SNPs in southern Chinese subjects. Phase II: to identify the candidate gene(s) by differential gene expression method.

 

Project Title:

To evaluate the role of Estrogen Receptor Alpha CA repeat Polymorphism as a Predictor of Osteoporosis and Facture Risk and To determine the Functional Mechanism of this Polymorphism in Human Bone Cells

Investigator(s):

Kung AWC, Luk KDK

Department:

Medicine

Source(s) of Funding:

Small Project Funding

Start Date:

12/2005

Completion Date:

02/2007

 

Abstract:

Estrogen deficiency is the major cause of post-menopausal osteoporosis [1]. Current evidence strongly supports that estrogen receptor alpha (ERα) is the main mediator of estrogenic action in bone [2-4]. Both in vitro [5-7] and animal studies [8, 9] have shown that ERα deficiency, as similar to estrogen deficiency, gives rise to low bone mineral density (BMD), rapid bone loss and increased fracture risk [10, 11]. Indeed, the association of low bone mass and delayed skeletal maturation in a young man with mutation of ERα resulting in estrogen resistance confirms the importance of this receptor in bone metabolism in both sexes [12]. ERα is mediated by the ESR1 gene which is located at chromosome 6q25.1 [13]. Previous studies have shown that ESR1 is a susceptibility gene for low bone mass and osteoporotic fractures. A number of intronic polymorphisms such as the XbaI, PvuII, TA repeats of ESR1 are reported to be associated with fracture risk [11, 14] and bone loss [15, 16]. However, the functionality of these intronic polymorphisms is unclear and the mechanism for the association with osteoporosis is ill defined [10]. We hypothesized that other functional polymorphisms of the ESR1 gene is likely to explain the association of ESR1 gene and osteoporosis clinical endpoints. D6S440 is a dinucleotide CA repeat polymorphism recently identified in intron 5 of ESR1. This locus is located 200 kb from the transcription start site of the gene but the importance of this polymorphism has not been studied. In the past, intronic dinucleotide repeat polymorphisms of such distance from the promoter were not considered to have any functional significance. However, recent reports on the intronic CA repeat polymorphism of the endothelial nitric oxide synthase (eNOS) gene has shown that CA repeats near 5' splicing sites may act as splicing enhancers affecting mRNA splicing efficiency [17]. As D6S440 is located 235 base-pairs downstream of the 5' splicing site of exon 5 in the ESR1 gene, we suspected that D6S440 may also be a potential polymorphic site for mRNA splicing modulation. The objective of this study was first, to investigate the role of this locus as a genetic marker for predicting BMD, fracture risk and rate of bone loss and second, to study the relation between CA repeat allele size and ESR1 mRNA transcript levels. Reference: 1. Albright F, et al. Post-menopausal osteoporosis. Trans Assoc Am Physicians. 1940;55:298-305. 2. Penolazzi, L., et al., Methylation analysis of the promoter F of estrogen receptor alpha gene: effects on the level of transcription on human osteoblastic cells. J Steroid Biochem Mol Biol, 2004. 91(1-2): p. 1-9. 3. Lee, K., et al., Endocrinology: bone adaptation requires oestrogen receptor-alpha. Nature, 2003. 424(6947): p. 389. 4. Waters, K.M., et al., Estrogen regulation of human osteoblast function is determined by the stage of differentiation and the estrogen receptor isoform. J Cell Biochem, 2001. 83(3): p. 448-62. 5. Cheng, M.Z., et al., Human osteoblasts' proliferative responses to strain and 17beta-estradiol are mediated by the estrogen receptor and the receptor for insulin-like growth factor I. J Bone Miner Res, 2002. 17(4): p. 593-602. 6. Jessop, H.L., et al., Osteoblast-like cells from estrogen receptor alpha knockout mice have deficient responses to mechanical strain. J Bone Miner Res, 2004. 19(6): p. 938-46. 7. Di Gregorio, G.B., et al., Attenuation of the self-renewal of transit-amplifying osteoblast progenitors in the murine bone marrow by 17 beta-estradiol. J Clin Invest, 2001. 107(7): p. 803-12. 8. Syed, F. and S. Khosla, Mechanisms of sex steroid effects on bone. Biochem Biophys Res Commun, 2005. 328(3): p. 688-96. 9. Gallagher, A., T.J. Chambers, and J.H. Tobias, The estrogen antagonist ICI 182,780 reduces cancellous bone volume in female rats. Endocrinology, 1993. 133(6): p. 2787-91. 10. Gennari, L., et al., Estrogen receptor gene polymorphisms and the genetics of osteoporosis: a HuGE review. Am J Epidemiol, 2005. 161(4): p. 307-20. 11. Ioannidis, J.P., et al., Differential genetic effects of ESR1 gene polymorphisms on osteoporosis outcomes. JAMA, 2004. 292(17): p. 2105-14. 12. Smith, E.P., et al., Estrogen resistance caused by a mutation in the estrogen-receptor gene in a man. N Engl J Med, 1994. 331(16): p. 1056-61. 13. Menasce, L.P., et al., Localization of the estrogen receptor locus (ESR) to chromosome 6q25.1 by FISH and a simple post-FISH banding technique. Genomics, 1993. 17(1): p. 263-5. 14. Langdahl, B.L., et al., A TA repeat polymorphism in the estrogen receptor gene is associated with osteoporotic fractures but polymorphisms in the first exon and intron are not. J Bone Miner Res, 2000. 15(11): p. 2222-30. 15. Kobayashi, N., et al., Estrogen receptor alpha polymorphism as a genetic marker for bone loss, vertebral fractures and susceptibility to estrogen. Maturitas, 2002. 41(3): p. 193-201. 16. Sowers, M., et al., Estrogen receptor genotypes and their association with the 10-year changes in bone mineral density and osteocalcin concentrations. J Clin Endocrinol Metab, 2004. 89(2): p. 733-9. 17. Hui, J., et al., HnRNP L stimulates splicing of the eNOS gene by binding to variable-length CA repeats. Nat Struct Biol, 2003. 10(1): p. 33-7.

 

List of Research Outputs

 

Cheung C.L., Ng W.W., Lai M.H., Chan V.N.Y. and Kung A.W.C., Association of a single nucleotide polymorphism in low-density lipoprotein receptor-related protein 5 (LRP5) gene promoter region with peak bone mineral density: A case-control study, 27th Annual Meeting of the American Society for Bone & Mineral Research, 23-27 September 2005, Nashville, USA. 2005.

 

Cheung E.Y.N., Ho A.Y.Y., Lam K.F., Tam S. and Kung A.W.C., Determinants of bone mineral density in Chinese men, Osteoporosis International. Springer London, 2005, 16: 1481-1486.

 

Cheung W.M.W., Ng W.S. and Kung A.W.C., Dimethyl Sulfoxide enhances osteoblastic differentiation of murine pre-osteoblast cells, 27th Annual Meeting of the American Society for Bone & Mineral Research, September 23-27, 2005, Tennessee, USA. Journal of Bone and Mineral Research, M208. 2005.

 

Cheung W.M.W., Ng W.S. and Kung A.W.C., Dimethyl sulfoxide as an inducer of differentiation in preosteoblast MC3T3-E1 cells, FEBS Letter. 2006, 580: 121-6.

 

Gu J., Lai M.H., Chan V.N.Y. and Kung A.W.C., Association of estrogen receptor beta gene polymorphisms and rate of bone loss in perimenopausal women, 27th Annual Meeting of the American Society for Bone & Mineral Research, 23-27 September 2005, Nashville, USA. 2005.

 

Ku C.F., Lo C.Y., Chan W.F., Kung A.W.C. and Lam K.S.L., Total thyroidectomy replaces subtotal thyroidectomy as the preferred surgical treatment for Graves' disease, ANZ J Surg. 2005, 75(7):: 528-31.

 

Kung A.W.C., Pasion E.G., Sofiyan M., Lau E.M.C., Tay B.K., Lam K.S., Wilawan K., Ongpipadhanakul B. and Thiebaud D., A comparison of teriparatide and calcitonin therapy in postmenopausal Asian women with osteoporosis: a 6-month study, Curr Med Res Opin. 2006, 22: 929-37.

 

Kung A.W.C., Ho A.Y.Y., Ross P.D. and Reginster J.Y., Development of a clinical assessment tool in identifying Asian men with low bone mineral density and comparison of its usefulness to quantitative bone ultrasound, Osteoporos Int. 2005, 16: 849-55.

 

Kung A.W.C., Diagnosis & fracture risk assessment (Plenary Session), 5th Scientific Meeting 2006 of Malaysian Osteoporosis Society, 13-15 Jan 2006, Kuala Lumpur, Malaysia. 2006.

 

Kung A.W.C., Editor, MIMS Endocrinology Guide, Singapore. 2005.

 

Kung A.W.C., Editorial Board Member of Osteoporosis International, Chinese Medical Journal, and China Osteoporosis Journal. 2006.

 

Kung A.W.C., Effects of Estrogen and Androgen on Bone, In: Deng HW & YZ Liu , Current Topics in Bone Biology . World Scientific Press, 2006, 213-250.

 

Kung A.W.C., Geusens P., Walliser J., Rovayo R., Shivaprakash M., Verbruggen N., Wehren L.E. and Melton M.E., Effects of once-monthly oral ibandronate on serum ctx levels: results of a 3-month randomized trial, The IOF World Congress on Osteoporosis, 2-6 June 2006, Toronto, Canada. 2006.

 

Kung A.W.C., Lai M.H., Ng M.Y.M., Cheung W.M.W., Chan V.N.Y. and Sham P.C., Estrogen receptor beta polymorphisms predict risks of osteoporosis in men and women: A linkage and association study, 27th Annual Meeting of the American Society for Bone & Mineral Research, 23-27 September 2005, Nashville, USA. 2005.

 

Kung A.W.C., HRT / SERMS, 5th Scientific Meeting 2006 of Malaysian Osteoporosis Society, 13-15 Jan 2006, Kuala Lumpur, Malaysia. 2006.

 

Kung A.W.C., Medical management of osteoporosis, Advances in Medicine 2006, 10-11 June, Hong Kong. 2006.

 

Kung A.W.C., Oral Symposium (Chairman), The 2nd International Conference on Osteoporosis and Bone Research, 19-23, Oct 2005, Chengdu, China. 2005.

 

Kung A.W.C., Osteoporosis, clinical assessment and management, Macau Continuous Medical Education in Internal Medicine 2004/05, 6 August 2005.

 

Kung A.W.C., Osteoporosis: management and monitoring (Plenary Session), 5th Scientific Meeting 2006 of Malaysian Osteoporosis Society, 13-15 Jan 2006, Kuala Lumpur, Malaysia. 2006.

 

Kung A.W.C., Prevalence of vitamin D deficiency in Hong Kong adults, '2 in 1’ Therapy in Concert. 2005.

 

Kung A.W.C., Prevalence of vitamin D deficiency in Hong Kong adults, Scientific Meeting of Osteoporosis Society of Hong Kong, 17 December 2005. 2005.

 

Kung A.W.C. and Lee K.K., Prior use of alendronate in patients with primary hyperparathyroidism did not affect bone mineral density improvement after parathyroidectomy, Endocrine Society Annual Meeting, 24-27 June 2006, Boston, USA. 2006.

 

Kung A.W.C., Rovayo R., Geusens P., Walliser J., Verbruggen N., Shivaprakash M., Wehren L.E. and Melton M.E., Results of a 3-month randomized trial to examine week-by-week effects of monthly ibandronate on biochemical markers of bone resorption, The IOF World Congress on Osteoporosis, 2-6 June 2006, Toronto, Canada. 2006.

 

Kung A.W.C., Reviewer for abstracts , 29th Scientific Meeting of American Society of Bone and Mineral Research, 2006. 2006.

 

Kung A.W.C., Chan W.M. and Lee K.K., Risk factors for hip fractures in Chinese postmenopausal women: a prospective study, The IOF World Congress on Osteoporosis, 2-6 June 2006, Toronto, Canada. 2006.

 

Kung A.W.C., Secondary osteoporosis, Hong Kong Allergy Convention, 7 August 2005.

 

Kung A.W.C., Lai M.H., Ng M.Y.M., Chan V.N.Y. and Sham P.C., T-1213C polymorphism of estrogen receptor beta is associated with low bone mineral density and osteoporotic fractures, Bone. 2006.

 

Kung A.W.C., Lau K.S., Cheung W.M.W. and Chan V.N.Y., Thyrotoxic periodic paralysis and polymorphisms of sodium-potassium ATPase genes, Clin Endocrinol (Oxf). 2006, 64: 158-61.

 

Kwong Y.L., Lau W.C.S., Ho S.L., Epstein R., Young R.T.T., Chan H.H.L., Tse H.F., Lam L., Chen W.H., Lee K.L.F., Ip M.S.M., Tsang K.W.T., Lam B., Tang S.C.W., Chan R.H.W., Lee S.W.L., Tan K.C.B., Yeung C.K., Chan D.T.M., Wong R.W.S., Choy C.B.Y., Wong B.C.Y., Li F.K., Lo W.K., Lui S.L., Cheung R.T.F., Mak W., Ho J.C.M., Mok T.M.Y., Kung A.W.C., Cheung B.M.Y., Chow W.S., Yuen R.M.F. and Wat N.M.S., In: Lau CP, Kumana CR, Lai CL, Lai KN, Lam KSL, Lam WK, Problem-Based Medical Case Management. Hong Kong, Hong Kong University Press, 2005.

 

Lai M.H. and Kung A.W.C., Dinucleotide CA repeat polymorphisms in ESR1 gene are associated with increased risk of low BMD and osteoporotic fractures, 27th Annual Meeting of the American Society for Bone & Mineral Research, 23-27 September 2005, Nashville, USA. 2005.

 

Lai M.H., Luk K.D.K. and Kung A.W.C., ESR1 CA(n) repeat polymorphism is associated with increased risk of osteoporotic fractures and estrogen receptor alpha: mrna expression in bone, The IOF World Congress on Osteoporosis, 2-6 June 2006, Toronto, Canada. 2006.

 

Lau H.L., Ng M.Y.M., Cheung W.M.W., Paterson A.D., Sham P.C., Luk K.D.K., Chan V.N.Y. and Kung A.W.C., Assessment of linkage and association of 13 genetic loci with bone mineral density, Journal of Bone and Mineral Metabolism. 2006, 24: 226-34.

 

Lau H.L., Ng M.Y.M., Jin L., Paterson A., Sham P.C., Luk K.D.K., Chan V.N.Y. and Kung A.W.C., Test of linkage and association of 14 genetic loci with bone size, 27th Annual Meeting of the American Society for Bone & Mineral Research, 23-27 September 2005, Nashville, USA. 2005.

 

Siu C.W.D., Jim M.H., Kung A.W.C., Lau C.P. and Tse H.F., The Outcomes of Thyrotoxicosis Related New-Onset Atrial Fibrillation, JACC. 2006, 47: 10A.

 

Siu D.C.H., Yeung C.Y., Kung A.W.C., Lau C.P. and Tse H.F., Prevalence, clinical characteristics and outcomes of thyrotoxic dilated cardiomyopathy as the initial presentation in patients with thyrotoxicosis, American Heart Association Annual Scientific Meeting, 13-16 November 2005, Dallas, USA. 2005.

 

Researcher : Kung MHW



List of Research Outputs

 

Ho W.L., Kwok H.H., Chu C.Y.A., Ho W.M., Kung M.H.W., Ramsden D.B. and Ho S.L., Silencing Of Ucp5 Enhances Mpp+-induced Neurotoxicity In Sh-sy5y Cells. , Mov Disorders. 2006, 20(10): 14.

 

Researcher : Kwan TF



List of Research Outputs

 

Kwan T.F., Liang R.H.S., Verfaillie C.M., Ekker S.C., Chan L.C., Lin S. and Leung A.Y.H., Regulation of primitive hematopoiesis in zebrafish embryos by the death receptor gene, Experimental Hematology . 2006, 34(1): 27-34.

 

Leung A.Y.H., Leung J.C.K., Chan Y.Y., Ma E.S.K., Kwan T.F., Lai K.N., Meng A. and Liang R.H.S., Proliferating cell nuclear antigen (PCNA) as a proliferative marker during embryonic and adult zebrafish hematopoiesis, Histochemistry and Cell Biology. 2005, 124(2): 105-11.

 

Researcher : Kwok CL



List of Research Outputs

 

Wong D.K.H., Yuen R.M.F., Tanaka Y., Lai C.L., Kwok C.L. and Mizokami M., Correlation between Hepatitis B virus core-related antigens and intrahepatic covalently closed circular DNA levels, Hepatology. 2005, 42 (Suppl 1): 712A.

 

Researcher : Kwok HH



List of Research Outputs

 

Ho W.L., Kwok H.H., Chu C.Y.A., Ho W.M., Kung M.H.W., Ramsden D.B. and Ho S.L., Silencing Of Ucp5 Enhances Mpp+-induced Neurotoxicity In Sh-sy5y Cells. , Mov Disorders. 2006, 20(10): 14.

 

Pawade T., Ho W.L., Kwok H.H., Chu A.C.Y., Ho S.L. and Ramsden D.B., Uncoupling Proteins: Targets Of Endocrine Disruptors?, In: I.T. Huhtaniemi, W.E. Rainey , R.J. Rodgers , Molecular and Cellular Endocrinology. Ireland, Elsevier, 2005, 244: 79-86.

 

Song Y., Ho W.L., Kwok H.H., Chu A.C.Y., Li Y. and Ho S.L., Genetic study of a large Chinese amyotrophic lateral sclerosis family., The 55th American society of Human Genetics meeting, October 25-29, 2005, Salt Lake City Utah, USA . 2005.

 

Researcher : Kwok HH



List of Research Outputs

 

Ho W.L., Kwok H.H., Chu C.Y.A., Ho W.M., Kung M.H.W., Ramsden D.B. and Ho S.L., Silencing Of Ucp5 Enhances Mpp+-induced Neurotoxicity In Sh-sy5y Cells. , Mov Disorders. 2006, 20(10): 14.

 

Pawade T., Ho W.L., Kwok H.H., Chu A.C.Y., Ho S.L. and Ramsden D.B., Uncoupling Proteins: Targets Of Endocrine Disruptors?, In: I.T. Huhtaniemi, W.E. Rainey , R.J. Rodgers , Molecular and Cellular Endocrinology. Ireland, Elsevier, 2005, 244: 79-86.

 

Song Y., Ho W.L., Kwok H.H., Chu A.C.Y., Li Y. and Ho S.L., Genetic study of a large Chinese amyotrophic lateral sclerosis family., The 55th American society of Human Genetics meeting, October 25-29, 2005, Salt Lake City Utah, USA . 2005.

 

Researcher : Kwong YL



Project Title:

Provision of purine analogues for the treatment of patients with chronic lymphoid malignancies

Investigator(s):

Kwong YL, Liang RHS

Department:

Medicine

Source(s) of Funding:

S.K. Yee Medical Foundation - General Award

Start Date:

07/1997

 

Abstract:

To provide purine analogues for the treatment of patients with chronic lymphoid malignancies who cannot otherwise afford the drugs.

 

Project Title:

Molecular mechanisms and consequences of downregulation of p73 in natural killer cell lymphoma

Investigator(s):

Kwong YL, Siu L.L.P.

Department:

Medicine

Source(s) of Funding:

Small Project Funding

Start Date:

11/2002

 

Abstract:

To define if p73 acts as a tumor suppressor gene in natural killer (NK) cell lymphomas; to define the biologic significance of re-expression of p73 in NK lumphoma cells that have p73 inactivated due to aberrant promoter methylation; to define the potential significance of p21 inactivation in NK lymphoma cells.

 

Project Title:

Molecular basis of arsenic resistance in tumours

Investigator(s):

Kwong YL, Tse EWC

Department:

Medicine

Source(s) of Funding:

Small Project Funding

Start Date:

11/2003

 

Abstract:

To define the molecular basis of arsenic resistance in tumour cells.

 

Project Title:

Activation of the JAK/STAT pathways in the molecular pathogenesis of natural killer cell lymphomas

Investigator(s):

Kwong YL

Department:

Medicine

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

Completion Date:

10/2006

 

Abstract:

To define the involvement of JAK/STAT, MEK/ERK and PI3-K/Akt signaling pathways in the pathogenesis of natural killer (NK) cell lymphomas.

 

Project Title:

Provision of free cytogenetic and molecular testing for monitoring of disease relapse after bone marrow transplantation

Investigator(s):

Kwong YL, Liang RHS, Lie AKW, Au WY

Department:

Medicine

Source(s) of Funding:

S.K. Yee Medical Foundation - General Award

Start Date:

11/2004

 

Abstract:

To establish provisions of (a) free molecular / cytogenetic tests for monitoring of BMT patients, (b) free molecular / cytogenetic tests for BMT patients who have relapsed, so that their treatment can be guided and optimized, (c) free molecular / cytogenetic tests for referral patients from other hospitals.

 

List of Research Outputs

 

Au W.Y., Lam C.C.K., Chim J.C.S., Pang A.W.K. and Kwong Y.L., Alemtuzumab induced complete remission of therapy-resistant pure red cell aplasia , Leukemia Research . 2005, 29, Issue 10: 1213-1215.

 

Au W.Y., Pang A.W.K., Wan T.S.K., Ma E.S.K., Cheng L.C. and Kwong Y.L., Concomitant post-transplantation lymphoproliferative disease and therapy-related myelodysplastic syndrome after lung transplantation , The Journal of Heart and Lung Transplantation . 2006, 25(2): 259-260.

 

Au W.Y., Tam S., Fong B.M. and Kwong Y.L., Elemental arsenic entered the cerebrospinal fluid during oral arsenic trioxide treatment of meningeal relapse of acute promyelocytic leukemia , Blood. 2006, 107(7): 3012-3013.

 

Au W.Y., Pang A.W.K., Chan C., Chu K.M., Shek T.W.H. and Kwong Y.L., Epstein-barr virus-related gastric adenocarcinoma: an early secondary cancer post hemopoietic stem cell transplantation, Gastroenterology. 2005, 129(6): 2058-63.

 

Au W.Y. and Kwong Y.L., Frequent varicella zoster reactivation associated with therapeutic use of arsenic trioxide: portents of an old scourge, Journal of the American Academy of Dermatology. 2005, 53(5): 890-2.

 

Au W.Y., Kwong Y.L. and Yuen K.Y., Hemophagocytosis in the peripheral blood due to tuberculosis mycobacteremia, American Journal of Medicine. 2005, 118(11): 1298-9.

 

Au W.Y., Lie A.K.W., Cheng J.W., Liang R.H.S. and Kwong Y.L., Long-term donor health and its relationship with outcome of allogeneic hematopoietic stem cell transplantation, Bone Marrow Transplantation. 2006, 37(5): 451-3.

 

Au W.Y., Chan L.C., Liang R.H.S. and Kwong Y.L., Myelodysplastic syndrome and acute myeloid leukemia after treatment with fludarabine, mitoxantrone, and dexamethasone, American Journal of Hematology. 2006, 81(6): 471-3.

 

Au W.Y. and Kwong Y.L., Peripartum pulmonary embolism in a patient with concomitant hemoglobin Newcastle, hemoglobin Constant Spring, and hereditary spherocytosis, American Journal of Hematology. 2005, 80(2): 166.

 

Au W.Y., Fung T.K., Ma E.S.K., Chan C.H., Wong K.F., Chim J.C.S., Liang R.H.S. and Kwong Y.L., Serial studies of methylation of CDKN2B and CDKN2A in relapsed acute promyelocytic leukaemia treated with arsenic trioxide, British Journal of Haematology. 2005, 131: 632.

 

Au W.Y., Kumana C.R., Lam C.W., Cheng V.C.C., Shek T.W.H., Chan E.Y.T., Liu K.Y. and Kwong Y.L., Solid tumors subsequent to arsenic trioxide treatment for acute promyelocytic leukemia, Leukemia Research. 2006.

 

Au W.Y., Ma E.S.K., Choy C., Chung L.P., Fung T.K., Liang R.H.S. and Kwong Y.L., Therapy-related lymphomas in patients with autoimmune diseases after treatment with disease-modifying anti-rheumatic drugs, American Journal of Hematology. 2005, 81(1): 5-11.

 

Chan O.O., Peng J., Lam S.K., Lai K.C., Yuen R.M.F., Cheung K.L., Kwong Y.L., Rashid A., Chan C.K. and Wong B.C.Y., Eradication of Helicobacter pylori Infection Reverses E-cadherin Promoter Hypermethylation, Gut. 2006, 55: 463-468.

 

Chen W.Y.W., Hu X., Liang A.C.T., Au W.Y., So J.C.C., Wong M.L.Y., Shen L., Tao Q., Chu K.M., Kwong Y.L., Liang R.H.S. and Srivastava G., High BCL6 expression predicts better prognosis, independent of BCL6 translocation status, translocation partner, or BCL6 deregulating mutations, in gastric lymphoma, Blood. 2006, 108(7): 2373-83.

 

Cheung W.M.W., Chu W.K. and Kwong Y.L., Effects of arsenic trioxide on the cellular proliferation, apoptosis and differentiation of human neuroblastoma cells, Cancer Letters. 2006.

 

Cheung W.W., Hwang G.Y.Y., Tse E.W.C. and Kwong Y.L., Alemtuzumab induced complete remission of autoimmune hemolytic anemia refractory to corticosteroids, splenectomy and rituximab, Haematologica. 2006, 91(5suppl): ECR13.

 

Chim J.C.S., Liang R.H.S., Leung S.M.H., Yip S.F. and Kwong Y.L., Aberrant gene promoter methylation marking disease progression in multiple myeloma, Leukemia. 2006, 20(6): 1190-2.

 

Chim J.C.S., Wong A.S.P., Pang A.W.K., Chu P., Lau J.S., Wong K.F. and Kwong Y.L., Aberrant promoter methylation of the retinoic acid receptor alpha gene in acute promyelocytic leukemia, Leukemia. 2005, 19(22): 2241-6.

 

Chim J.C.S. and Kwong Y.L., Adverse prognostic impact of CDKN2B hyper-methylationin acute promyelocytic leukemia , Leukemia & Lymphoma . 2006, 47(5): 815-25.

 

Chim J.C.S., Wong A.S.Y. and Kwong Y.L., Epigenetic inactivation of the CIP/KIP cell-cycle control pathway in acute leukemias, American Journal of Hematology. 2005, 80(4): 282-7.

 

Chim J.C.S., Kwong Y.L., Lie A.K.W., Ma E.S.K., Chan C.C., Wong L.G., Kho B.C., Lee H.K., Sim J.P., Chan C.H., Chan J.C., Yeung Y.M., Law W. and Liang R.H.S., Long-term Outcome of 231 Patients With Essential Thrombocythemia , Archives of Internal Medicine. 2005, 165(22): 2651-8.

 

Chim J.C.S., Chan W.W.L., Pang A.W.K. and Kwong Y.L., Preferential methylation of Wnt inhibitory factor-1 in acute promyelocytic leukemia: an independent poor prognostic factor, Leukemia. 2006, 20(5): 907-9.

 

Hu X., Liang A.C.T., Chen W.Y.W., Tao Q., Wong M.L.Y., Shen L., Wong K.Y., Au W.Y., Cheung W.L., Chu K.M., Kwong Y.L., Liang R.H.S. and Srivastava G., CD44 expression is regulated by translocation and promoter hypermethylation in gastric lymphoma, Proceedings of the 12th Hong Kong International Cancer Congress and 2nd Annual Meeting of Centre for Cancer Research, Hong Kong SAR, China, December 2005.

 

Hu X., Liang A.C.T., Chen W.Y.W., Tao Q., Au W.Y., Wong M.L.Y., Shen L., Wong K.Y., Wan T.S.K., Cheung W.L., Chu K.M., Chan L.C., Kwong Y.L., Liang R.H.S. and Srivastava G., CD44 expression is regulated by translocation and promoter hypermethylation in gastric lymphoma, Proceedings of 97th Annual Meeting of American Association for Cancer Research (AACR), Washington D.C., USA, April 2006 . 2006.

 

Hui C.K., Lie A.K.W., Au W.Y., Leung A.Y.H., Ma S.Y., Cheung W.W., Zhang H., Chim J.C.S., Kwong Y.L., Liang R.H.S. and Lau G., A long-term follow-up study on hepatitis B surface antigen-positive patients undergoing allogeneic hematopoietic stem cell transplantation, Blood. 2005, 106(2): 464-9.

 

Hui C.K., Cheung W., Au W.Y., Lie A.K.W., Zhang H., Yueng Y.H., Wong B.C.Y., Leung N., Kwong Y.L., Liang R.H.S. and Lau G., Hepatitis B reactivation after withdrawal of preemptive lamivudine in patients with hematological malignancy upon completion of cytotoxic chemotherapy, Liver International 2005. 2005, Oct: 182.

 

Hui C.K., Ma S.Y., Sun J., Au W.Y., Lie A.K.W., Chim J.C.S., Kwong Y.L., Liang R.H.S. and Lau G., Hepatitis B reactivation in patient with occult HBV infection after chemotherapy, J Hepatol. 2005, 42(6): 813-19.

 

Hui C.K., Cheung W.W., Zhang H., Au W.Y., Yueng Y.H., Leung A.Y.H., Leung N., Luk J.M.C., Lie A.K.W., Kwong Y.L., Liang R.H.S. and Lau G., Kinetics and risk of de novo hepatitis B infection in HBsAg negative patients undergoing cytotoxic chemotherapy, Gastroenterology. 2006, 131: 59-68.

 

Hui C.K., Cheung W.W., Zhang H., Au W.Y., Yueng Y.H., Leung A.Y.H., Leung N., Luk J.M.C., Lie A.K.W., Kwong Y.L., Liang R.H.S. and Lau G., Rituximab increases the Risk of De Novo hepatitis B infection in Hepatitis B Surface Antigen Negative Patients Undergoing Cytotoxic Chemotherapy, J Gastroenterol and Hepatol. 2006, 21(2): A73.

 

Jin Y., Feng H., Deng W., Zhang H., Lu M., Jin C., Tsao G.S.W. and Kwong Y.L., Immortalization of human extravillous cytotrophoblasts by human papilloma virus gene E6E7: sequential cytogenetic and molecular genetic characterization, Cancer Genetics and Cytogenetics. 2005, 163: 30-37.

 

Kwong Y.L., Chow C., Kumana C.R., Srivastava G. and Au W.Y., Arsenic trioxide in mantle cell lymphoma, Blood (American Society of Hematology 2005 Annual Meeting Abstracts) . 2005, 106 (11): 283B-284B 4814 Part 2 Nov 16 2005.

 

Kwong Y.L., Natural killer cell lymphoma: diagnosis and treatment, Leukemia. 2005.

 

Kwong Y.L., Lau W.C.S., Ho S.L., Epstein R., Young R.T.T., Chan H.H.L., Tse H.F., Lam L., Chen W.H., Lee K.L.F., Ip M.S.M., Tsang K.W.T., Lam B., Tang S.C.W., Chan R.H.W., Lee S.W.L., Tan K.C.B., Yeung C.K., Chan D.T.M., Wong R.W.S., Choy C.B.Y., Wong B.C.Y., Li F.K., Lo W.K., Lui S.L., Cheung R.T.F., Mak W., Ho J.C.M., Mok T.M.Y., Kung A.W.C., Cheung B.M.Y., Chow W.S., Yuen R.M.F. and Wat N.M.S., In: Lau CP, Kumana CR, Lai CL, Lai KN, Lam KSL, Lam WK, Problem-Based Medical Case Management. Hong Kong, Hong Kong University Press, 2005.

 

Leung A.Y.H., Yuen K.Y. and Kwong Y.L., Polyma BK virus and haemorrhagic cystitis in haematopoietic stem cell transplantation - a changing paradigm, Bone Marrow Transplantation. 2005.

 

Leung A.Y.H., Yuen K.Y. and Kwong Y.L., Polyoma BK virus and haemorrhagic cystitis in haematopoietic stem cell transplantation: a changing paradigm, Bone Marrow Transplantation. 2005, 36(11): 929-37.

 

Leung A.Y.H., Wong A.S.Y., Chan G.C.F., Yuen K.Y. and Kwong Y.L., Urinary reactivation of polyoma BK virus but not adenovirus in paediatric and adolescent patients after haematopoietic stem cell transplantation, Bone Marrow Transplantation. 2006, 37(6): 621-3.

 

Leung R., Chou E.E., Au W.Y., Chow C., Kwong Y.L., Lin S.Y., Ma E.S.K., Wan T.S.K. and Wong K.F., CD4+/CD56+ hematologic malignancy with rearranged MLL gene, Human Pathology . 2006, 37(2): 247-249.

 

Li H.M., Man C.W.Y., Jin Y., Deng W., Yip Y.L., Feng H., Cheung Y.C., Lo K.W., Meltzer P.S., Wu Z.G., Kwong Y.L., Yuen P.W. and Tsao G.S.W., Molecular and cytogenetic changes involved in the immortalization of nasopharyngeal epithelial cells by telomerase, International Journal of Cancer. 2006, 119: 1567-1576.

 

Man C.W.Y., Rosa J., Wu Z.Q., Akira H., Jin D., Ling M.T., Cheung A., Kwong Y.L., Doxsey S. and Tsao G.S.W., ID1 Upregulates Aurora Kinase A, Induces Centrosome abnormalities, Polyploidy and Disrupts Microtubule Integrity, 10th Research Postgraduate Symposium, Faculty of Medicine, HKU, December 3, 2005 . 2005.

 

Man C.W.Y., Rosa J., Lee T.O., Lee H.Y.V., Chow B.K.C., Lo K.W., Doxsey S., Wu Z.G., Kwong Y.L., Jin D., Cheung A. and Tsao G.S.W., Latent membrane protein 1 suppresses RASSFIA expression, disrupts microtubule structures and induces chromosomal aberrations in human epithelial cells, Oncogene. 2006, 1-12.

 

Pang R.W.C., Poon R.T.P., Lee K.W., Fan S.T., Kwong Y.L. and Tse E.W.C., PIN1 interacts with a specific serine-proline motif of hepatitis B virus X protein to enhance hepatocarcinogenesis (Abstract), The 97th Annual Meeting of the American Association of Cancer Research, Washington D.C., U.S.A., 1 - 5 April 2006.

 

Tse E.W.C., Yip S.F., Ooi C.G.C. and Kwong Y.L., Subarachnoid haemorrhage: more than meets the eye, British Journal of Haematology. 2006, 132(4): 383.

 

Yip B.H., Guo T., Hu X., Wong K.Y., Chen W.Y.W., Au W.Y., Chu K.M., Kwong Y.L., Liang R.H.S. and Srivastava G., Identification of two novel translocations t(14;20)(q32;q12) and t(2;14)(q23;q32) in gastric lymphoma, Proceedings of the 12th Hong Kong International Cancer Congress and 2nd Annual Meeting of Centre for Cancer Research, Hong Kong SAR, China, December 2005.

 

Yip B.H., Guo T., Hu X., Au W.Y., Wong K.Y., Wan T.S.K., Chen W.Y.W., Chu K.M., Chan L.C., Kwong Y.L., Liang R.H.S. and Srivastava G., Identification of two novel translocations t(14;20)(q32;q12) and t(2;14)(q23;q32) involving immunoglobulin heavy chain gene locus in gastric lymphoma, Proceedings of 97th Annual Meeting of American Association for Cancer Research (AACR), Washington D.C., USA, April 2006.

 

Zhang H., Jin Y., Chen X., Jin C., Law S.Y.K., Tsao G.S.W. and Kwong Y.L., Cytogenetic aberrations in immortalization of esophageal epithelial cells, Cancer Genetics and Cytogenetics. 2006, 165(1): 25-35.

 

Researcher : Lai AYK



List of Research Outputs

 

Ooi C.G.C., Ho J.C.M., Lam B., Lai A.Y.K., Tsang K.W.T. and Lam W.K., Relationship between MR intra-abdominal fat parameters and cardiovascular risk parameters in obstructive sleep apnoea, Respirology. 2005, 10 (Suppl): A176 (#366).

 

Researcher : Lai CL



List of Research Outputs

 

Chan H.L.Y., Lai C.L., Cho M., Heathcote J., Moon Y.-.M., Chao Y.-.C., Myers R., Minuk G., Marcellin P., Jeffers L., Sievert W., Kaiser R., Chao G. and Brown N., A randomized trial of telbivudine (LDT) vs. adefovir for HBeAg-positive chronic hepatitis B: Results of the primary week 24 analysis, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2006, 44 (Suppl 2): S24-25.

 

Chong W.P., To Y.F., Ip W.K.E., Yuen R.M.F., Poon R.T.P., Wong W.H.S., Lai C.L. and Lau Y.L., Mannose-binding lectin in chronic hepatitis B virus infection, Hepatology. 2005, 42(5): 1037-1045.

 

Gane E., Lai C.L., Liaw Y.F., Thongsawat S., Wang Y.M., Cheng Y., Heathcote J., Rasenack J., Bzowej N., Naoumov N., Chao G., Fielman B. and Brown N., Phase III comparison of telbivudine vs lamivudine in HBeAg-positive patients with chronic hepatitis B: Efficacy, safety, and predictors of response at 1 year, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2006, 44 (Suppl 2): S183-184.

 

Ito K., Tanaka Y., Orito E., Sugiyama M., Fujiwara K., Sugauchi F., Kato T., Tokita H., Izumi N., Kato M., Yuen R.M.F., Lai C.L., Gish R.G., Ueda R. and Mizokami M., T1653 Mutation in the Box Alpha Increases the Risk of Hepatocellular Carcinoma in Patients with Chronic Hepatitis B Virus Genotype C Infection, Clinical Infectious Disease. 2006, 42: 1-7.

 

Ito K., Tanaka Y., Sugiyama M., Fujiwara K., Sugauchi F., Orito E., Asahina Y., Tokita H., Yuen R.M.F., Lai C.L., Acharya S.A., Gish R. and Mizokami M., T1653 mutation in the box alpha increases the risk of hepatocellular carcinoma in patients with chronic hepatitis B virus infection, Hepatology. 2005, 42 (Suppl 1): 720A.

 

Lai C.L., "Treatment of chronic hepatitis B : New antiviral agents" and "Management of Chronic Hepatitis B and Update on Entecavir Global Studies", 2005 Entecavir National Train-the-Trainer Seminar in Jiu Zhai Gou, China, July 29. 2005.

 

Lai C.L., Leung N., Teo E.K., Tong M., Wong F., Hann H.W., Han S., Poynard T., Myers M., Chao G., Lloyd D., Brown N.A. and Telbivudine Phase II Investigator Group .., A 1-year trial of telbivudine, lamivudine, and the combination in patients with hepatitis B e antigen-positive chronic hepatitis B. , Gastroenterology. 2005, 129: 528-536.

 

Lai C.L., A phase III comparative trial of telbivudine (LdT) vs. lamivudine for chronic hepatitis B: First-year results from the large international GLOBE trial, Idenix/Novartis "Telbivudine Phase III GLOBE – US HBV Experts Forum" held in Hawaii, USA, December 15. 2005.

 

Lai C.L., BMS Satellite Symposium 'Time to ACT in Hepatitis B – Earlier intervention for a progressive diseases' on "A new treatment option for chronic hepatitis B infection: An update on entecavir", 15th Asian Pacific Association for the Study of the Liver, Bali, Indonesia, August 18-21. 2005.

 

Lai C.L., Chemoprophylaxis for Hepatocellulcar Carcinoma, 5th Shanghai International Conference on Gastroenterology, Shanghai, China, July 7. 2005.

 

Lai C.L., Co-chairman, A parallel session on "Cancer: Scientific Meeting of the Centre for Cancer Research" at the Frontiers in Biomedical Research 2005 organized by Faculty of Medicine, The University of Hong Kong on December 2. 2005.

 

Lai C.L., Co-chairman, Session on 'Haematology & Hepatology' at the 11th Hong Kong Medical Forum, Department of Medicine on June 4. 2006.

 

Lai C.L., Co-chairman, ShanghaiHong Kong International Liver Congress 2006. 2006.

 

Lai C.L., Current and Future Antivirals in the Management of CHB, Satellite Symosium (II) of the 2006 Spring Convention of Gastroenterological Society of Taiwan, March 17. 2006.

 

Lai C.L., Debate I: "Entecavir as first line treatment for CHB: Pro & Cons" , 15th Asian Pacific Association for the Study of the Liver, Bali, Indonesia, August 18-21. 2005.

 

Lai C.L., Duration of Therapy — How Long Do You Treat?, BMS Satellite Symposium entitled 'Expert Perspectives: Refining the HBV Treatment Paradigm' in the Digestive Disease Week, LA, USA between May 20-25. 2006.

 

Lai C.L., Editor for Hepatology, Journal of Gastroenterology and Hepatology. 2006.

 

Lai C.L., Shouval D., Lok A.S., Chang T.T., Cheinquer H., Goodman Z., DeHertogh D., Wilber R., Zink R.C., Cross A., Colonno R., Fernandes L. and BEHoLD AI463027 Study Group .., Entecavir Versus Lamivudine for Patients with HBeAg-Negative Chronic Hepatitis B, New England Journal of Medicine. 2006, 354: 1011-1020.

 

Lai C.L., Entecavir, other new oral antiviral drugs and future prospects for therapy of CHB, Symposium on ‘Current Management of Chronic Hepatitis B’ at the 14th Indian Association for the Study of the Liver Conference (INASL 2006) held in Nagpur, India, February 26. 2006.

 

Lai C.L., Chen S., Wong B.C.Y. and Yuen R.M.F., Gastroenterology and Hepatology., In: Lau CP, Chen MZ, Kumana CR, Lai CL, Lai KN, Lam KSL, Lam WK ed., Problem-Based Medical Cases Management. Hong Kong University Press, 2005, 75-107.

 

Lai C.L., HBV Genotypes: Implications in Management, Scientific Session 'Clinical Symposium 9: Viral Genotyping' at the 16th Asian Pacific Association for the Study of the Liver (APASL) in Manila, Philippines, March 7. 2006.

 

Lai C.L., HBV genotypes, Colloquium of Bristol-Myers Squibb Infectious Diseases Colloquium in New York, USA, October 20. 2005.

 

Lai C.L., HBV subtypes, genotypes and replicative states: What do they mean?, State-of-the-Art (IASL) lecture in the World Congress of Gastroenterology 2005 Meeting, Montreal, Canada, September 12-14. 2005.

 

Lai C.L., Hepatitis B Virus Subtypes, Genotypes and Replicative States: What Do They Mean? , State-of-the-Art-Lecture at the 7th Annual Scientific Meeting of the Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, January 21. 2006.

 

Lai C.L., Invited lecture on "Cost Effectiveness of Screening for Hepatocellular Carcinoma", Symposium for Medical & Health Professionals Liver Cancer: Prevention & Cure in 21st Century on "Screening and Prevention of Liver Cancer" organized by The Hong Kong Anti-Cancer Society. 2005.

 

Lai C.L., Management of Chronic Hepatitis B: Consensum and Controversies, BMS Symposium on 'Time to Act in Hepatitis B: Earlier Intervention for a Progressive Disease' held in Malaysia, April 20. 2006.

 

Lai C.L., Management of Chronic Hepatitis B: Consensus and Controversies, BMS Satellite symposium at the 16th Asian Pacific Association for the Study of the Liver (APASL) in Manila, Philippines, March 6. 2006.

 

Lai C.L., Management of Chronic Hepatitis B: Consensus and Controversies, BMS Symposium 'Time, Triggers and Treatment: Turning the Tide of Hepatitis B' in the Shanghai-Hong Kong International Liver Congress, Shanghai, China, March 26. 2006.

 

Lai C.L., Management of hepatitis B & update on entecavir global studies, Seminar organized by Associação Chinesa dos Profissionalis de Medicina de Macau, August 30. 2005.

 

Lai C.L., Maximal Early HBV Suppression is Predictive of Optimal Virologic and Clinical Efficacy in Nucleoside-Treated Hepatitis B Patients: Scientific Observations from A Large Multinational Trial (the GLOBE Study), 56th AASLD Annual Meeting in San Francisco, USA, November 11-15. 2005.

 

Lai C.L., Gane E., Liaw Y.F., Thongsawat S., Wang Y.M., Chen Y., Heathcote J., Rasenack J., Bzowej N., Naoumov N., Chao G., Fielman B., Brown N. and and the GLOBE Study Group .., Maximal early HBV suppression is predictive of optimal virologic and clinical efficacy in nucleoside-treated hepatitis B patients: scientific observations from a large multinational trial (the GLOBE study), Hepatology. 2005, 42 (Suppl 1): 232A.

 

Lai C.L., Member of the Editorial Advisory Board, Journal of Infectious Diseases. 2006.

 

Lai C.L., Member of the Editorial Board, Rawal Medical Journal, The Journal of the Pakistan Medical Association. 2006.

 

Lai C.L., Member of the Editorial Board, The Primary Care Clinic, CMPMedica, Hong Kong. 2006.

 

Lai C.L., New and Future Treatment Options for Chronic Hepatitis B, 11th Hong Kong Medical Forum, Department of Medicine on June 4. 2006.

 

Lai C.L., New and Future Treatment Options for Chronic Hepatitis B, 56th AASLD Annual Meeting in San Francisco, USA, November 11-15. 2005.

 

Lai C.L., Oral presentation on "Phase II, Multi-centre, Dose-escalating Study of LH80380 (ANA 380) in Hepatitis B Patients with Lamivudine-resistant YMDD Mutant HBV", 41st Annual Meeting of the European Association for the Study of the Liver held in Vienna, Austria, April 27. 2006.

 

Lai C.L., Oral presentation on "Telbivudine Displays Consistent Antiviral Efficacy Across Patients Subgroups for the Treatment of Chronic Hepatitis B: Results from the Globe Study", 16th Asian Pacific Association for the Study of the Liver (APASL) in Manila, Philippines, March 6. 2006.

 

Lai C.L., Han K.H., Yoon S.K., Um S.H., Yuen R.M.F., Kim H.S., Kim H.R., Chung H.C., Kim C.R., Hsyu P., Averett D., Worland S. and Kim J., Phase II, multi-centre, dose-escalating study of LB80380 (ANA380) in hepatitis B patients with lamivudine-resistant YMDD mutant HBV, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2006, 44 (Suppl 2): S5.

 

Lai C.L., Predictors of Viral Resistance: Conclusions from RCTs, Scientific Session 'Clinical Symposium 4: Chronic Hepatitis B: Viral Resistance' at the 16th Asian Pacific Association for the Study of the Liver (APASL) in Manila, Philippines, March 6. 2006.

 

Lai C.L., Relevance of Viral Load in the Management of Chronic Hepatitis B, BMS 'Meet-the-Experts Sessions' in the 41st Annual Meeting of the European Association for the Study of the Liver held in Vienna, Austria, April 26-30. 2006.

 

Lai C.L., Rising to the challenge in chronic hepatitis B management, BMS Symposium held under the auspices of Chatper of Gastroenterologists, College of Physicians, Singapore and Gastroenterological Society of Singapore, Singapore, March 1. 2006.

 

Lai C.L., Role of antiviral treatment for patients with hepatitis B related hepatocellular carcinoma, Singapore General Hospital, Singapore, March 1. 2006.

 

Lai C.L., Screening and Prevention of Liver Cancer, Symposium for Medical & Health Professionals Liver Cancer: Prevention & Cure in 21st Century organized by The Hong Kong Anti-Cancer Society, August 27. 2005.

 

Lai C.L., Telbivudine (LdT) vs. Lamivudine for Chronic Hepatitis B: First-Year Results from the International Phase III GLOBE Trial, 56th AASLD Annual Meeting in San Francisco, USA, November 11-15. 2005.

 

Lai C.L., Gane E., Liaw Y.F., Thongsawat S., Wang Y.M., Chen Y., Heathcote J., Rasenack J., Bzowej N., Naoumov N., Chao G., Fielman B., Brown N. and and the GLOBE Study Group .., Telbivudine (LdT) vs. lmivudine for chronic Hepatitis B: First-year results from the international phase III GLOBE trial, Hepatology. 2005, 42 (Suppl 1): 748A.

 

Lai C.L., The Natural History and Treatment of Chronic Hepatitis B: the Asian Perspective, BMS Scientific Meeting 'Viral Load and the Management of Chronic Hepatitis B: What can we learn from Cohort Studies' in the 41st Annual Meeting of the European Association for the Study of the Liver held in Vienna, Austria, April 28. 2006.

 

Lai C.L., The Natural History and Treatment of Chronic Hepatitis B: Consensus and Controversies, International Symposium on Hepatology 2005 organized by HKASLD in Hong Kong, November 25-26. 2005.

 

Lai C.L., The Natural History and Treatment of Chronic Hepatitis B: Consensus and Controversies, Leon Schiff State-of-the-Art Lecture at the 56th AASLD Annual Meeting in San Francisco, USA, November 11-15. 2005.

 

Lai C.L., The natural history and treatment of chronic hepatitis B: Consensus and controversies, BMS Chronic Hepatitis B Global Advisory Board held in Madrid, Spain, February 10. 2006.

 

Lai C.L., The role of Virus Level Reduction in Hepatitis B Management, Updates and New Treatment Options , Press Briefing presentation at the BMS Stand-Alone Meeting in Singapore, March 1. 2006.

 

Lai C.L., Treatment of Chronic Hepatitis B, 5th Shanghai International Conference on Gastroenterology, Shanghai, China, July 8. 2005.

 

Lai C.L., Treatment of Chronic Viral Hepatitis B & C, Seminar on Viral Hepatitis for Nurses 2006 held by Centre for Health Protection, Department of Health, Hong Kong on April 8. 2006.

 

Lai C.L., Treatment of HBeAg-positive chronic hepatitis B patients , 6th International Meeting on Therapy in Liver Diseases, Barcelona, Spain, September 28-30. 2005.

 

Lai C.L. and Yuen R.M.F., Treatment of HBeAg-positive chronic hepatitis B patients., In: Arroyo V, Navasa M, Forns X, Bataller R, Sanchez-Fueyo A, Rodes M ed., Update in treatment of liver disease. Ars Medica, Barcelona, Spain., 2005, 227-233.

 

Lim S.G., Lai C.L., Myers M., Yuen R.M.F., Wai C.T., Lyoyd D., Pietropaolo K., Zhou X.J., Chao G. and Brown N.A., Final results of a phase I/II dose escalation trial of valtorcitabine in patients with chronic hepatitis B., Journal of hepatology : the journal of the European Association for the Study of the Liver. 2005, 42 (Suppl 2): 16.

 

Naoumov N., Lai C.L., Gane E., Liaw Y.F., Thongsawat S., Wang Y.M., Heathcote E.J., Rasenack J., Bzowej N., Chao G. and Brown N., Effect of core promoter/precore mutation pattern and early virologic response on efficacy outcomes with telbivudine in HBeAg-negative chronic hepatitis B, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2006, 44 (Suppl 2): S276-277.

 

Orito E., Fujiwara K., Tanaka Y., Yuen R.M.F., Lai C.L., Kato T., Sugauchi F., Kusakabe A., Sata M., Okanoue T., Niitsuma H., Sakugawa H., Hasegawa I. and Mizokami M., A case-control study of response to lamivudine therapy for 2 years in Japanese and Chinese patients chronically infected with hepatitis B virus of genotypes Bj, Ba and C, Hepatology Research. 2006, 35: 127-134.

 

Schiff E., Lai C.L., Neuhaus P., Tillman H., Samuel D., Villeneuve J.P., Hadziyanni S., Arterburn S., Mommeja-Marin H. and Chuck S., Safety and efficacy of adefovir dipivoxil in patients with lamivudine-resistant chronic hepatitis B undergoing liver transplantation, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2006, 44 (Suppl 2): S3.

 

Shouval D., Akarca U.S., Hatzis G., Kitis G., Lai C.L., Cheinquer H., Chang T.T., Zink R., Zhu J. and Brett-Smith H., Continued virologic and biochemical improvement through 96 weeks of entecavir treatment in HBeAg() chronic hepatitis B patients (study ETV-027), Journal of hepatology : the journal of the European Association for the Study of the Liver. 2006, 44 (Suppl 2): S21-22.

 

Standring D.N., Seifer N., Patty A., Chapron C., Van Doorn L.J., Chao G., Brown N. and Lai C.L., HBV resistance determination from the telbivudine globe registration trial, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2006, 44 (Suppl 2): S191.

 

Sum S.M., Wong D.K.H., Yuen J.C.H., Lai C.L. and Yuen R.M.F., Comparison of the COBAS TaqMan HBV Test with the COBAS Amplicor Monitor Test for Measurement of Hepatitis B Virus DNA in Serum, Journal of Medical Virology. 2005, 77: 486-490.

 

Tanaka Y., Kurbanov F., Mano S., Orito E., Vargas V., Esteban J.I., Yuen R.M.F., Lai C.L., Kramvis A., Kew M.C., Smuts H.E., Netesov S.V., Alter H.J. and Mizokami M., Molecular Tracing of the Global Hepatitis C Virus Epidemic Predicts Regional Patterns of Hepatocellular Carcinoma Mortality, Gastroenterology. 2006, 130: 703-714.

 

Tanaka Y., Kurbanov F., Vargas V., Esteban J., Yuen R.M.F., Lai C.L., Kramvis A., Kew M., Alter H.J. and Mizokami M., Molecular tracing of the global hepatitis C virus epidemic predicts regional patterns of hepatocellular carcinoma mortality, Hepatology. 2005, 42 (Suppl 1): 434A.

 

Tanaka Y., Orito E., Yuen R.M.F., Mukaide M., Sugauchi F., Ito K., Ozasa A., Sakamoto T., Kurbanov F., Lai C.L. and Mizokami M., Two Subtypes (Subgenotypes) of Hepatitis B Virus Genotype C: A Novel Subtyping Assay Based on Restriction Fragment Length Polymorphism, Hepatology Research. 2005, 33: 216-224.

 

Tang L.P., Cho C.H., Hui W.M., Huang F.Y., Lai C.L., Xia H.H.X., Lam S.K., Rashid A., Wong B.C.Y. and Chan O.O., A negative correlation between IL-6 and DNA methylation in patients with gastric cancer, Supplement to Gastroenterology - Digestive Disease Week and the 107th Annual Meeting of the American Gastroenterological Association Institute, May 20-25, 2006, Los Angeles, CA. 2006, 130:4 Suppl 2: A-717.

 

Thongsawat S., Lai C.L., Gane E., Chao G., Fielman B., Brown N. and GLOBE Investigator Group .., Telbivudine displays consistent antiviral efficacy across patient subgroups for the treatment of chronic hepatitis B: Results from the GLOBE study, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2006, 44 (Suppl 2): S49.

 

Wong D.K.H., Yuen R.M.F., Tanaka Y., Lai C.L., Kwok C.L. and Mizokami M., Correlation between Hepatitis B virus core-related antigens and intrahepatic covalently closed circular DNA levels, Hepatology. 2005, 42 (Suppl 1): 712A.

 

Wong D.K.H., Tanaka Y., Lai C.L., Mizokami M. and Yuen R.M.F., Detection of hepatitis B virus core-related antigens as a marker for the monitoring of viral activity during nucleoside analogue therapy, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2006, 44 (Suppl 2): S192.

 

Wong D.K.H., Yuen R.M.F., Ngai W.S. and Lai C.L., One-year treatment of entecavir results in reduction in intrahepatic covalently closed circular DNA level, Hepatology. 2005, 42(Suppl 1): 573A.

 

Yuan H., Yuen R.M.F., Wong D.K.H., Sum S.M., Sablon E., Ng I.O.L. and Lai C.L., Impact of Precore and Core Promoter Mutations on Hepatic Histology in Patients with Chronic Hepatitis B, Alimentary Pharmacology and Therapeutics. 2005, 22: 301-307.

 

Yuan H.J., Yuen R.M.F., Wong D.K.H., Sablon E. and Lai C.L., The relationship between HBV-DNA levels and cirrhosis-related complications in Chinese with chronic hepatitis B, Journal of Viral Hepatitis. 2005, 12: 373-379.

 

Yuen R.M.F., Tanaka Y., Ng I.O.L., Mizokami M., Yuen J.C.H., Wong D.K.H., Yuan H., Sum S.M., Chan O.O. and Lai C.L., Hepatic necroinflammation and fibrosis in patients with genotypes Ba and C, core-promoter and precore mutations, Journal of Viral Hepatitis . 2005, 12(5): 513-8.

 

Yuen R.M.F., Wong D.K.H., Chan C.C.S., Zheng B.J., Yuen J.C.H. and Lai C.L., Immune response during immunoclearance phase of Chinese patients with HBV genotypes B and C., Journal of hepatology : the journal of the European Association for the Study of the Liver. 2005, 42 (Suppl 2): 152.

 

Yuen R.M.F., Seto W.K., Chow D.H.F., Tsui K., Wong D.K.H., Chan P., But D. and Lai C.L., Long-term beneficial outcome of Chinese asymptomatic patients with HBeAg-positive chronic hepatitis B on continuous lamivudine therapy: 7-year experience., Hepatology. 2005, 42 (4 Suppl 1): 583A.

 

Yuen R.M.F., Yuan H., Wong D.K.H., Yuen J.C.H., Wong R.W.M., Chan O.O., Wong B.C.Y., Lai K.C. and Lai C.L., Prognostic determinants for chronic hepatitis B in Asians: therapeutic implications. , Gut. 2005, 54(11): 1610-4.

 

Yuen R.M.F. and Lai C.L., Response to combined interferon and ribavirin is better in patients infected with hepatitis C virus genotype 6 than genotype 1 in Hong Kong. , Intervirology. 2006, 49(1-2): 96-8.

 

Yuen R.M.F., Sablon E., Libbrecht E., Van de Velde H., Wong D.K.H., Fung J.Y.Y., Wong B.C.Y. and Lai C.L., Significance of HBV DNA, core promoter/precore mutations, genotypes, specific sequences of polymerase gene on three-year lamivudine treatment: A predictive model for antiviral therapy, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2006, 44 (Suppl 2): S194.

 

Yuen R.M.F. and Lai C.L., Telbivudine: an upcoming agent for chronic hepatitis B. , Expert Rev Anti Infect Ther. 2005, 3(4): 489-94.

 

Zeuzem S., Lai C.L., Gane E., Liaw Y.F., Thongsawat S., Wang Y.M., Chen Y., Heathcote J., Rasenack J., Bzowej N., Naoumov N., Chao G., Fielman B. and Brown N., Optimal virologic and clinical efficacy at one year is associated with maximal early HBV suppression in nucleoside-treated hepatitis B patients, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2006, 44 (Suppl 2): S24.

 

Zhou X.J., Lim S.G., Lloyd D.M., Chao G.C., Brown N.A. and Lai C.L., Pharmacokinetics of Telbivudine Following Oral Administration of Escalating Single and Multiple Doses in Patients with Chronic Hepatitis B Virus Infection: Pharmacodynamic Implications , Antimicrobial Agents and Chemotherapy . 2006, 50: 874-879.

 

Researcher : Lai KC



List of Research Outputs

 

Chan O.O. and Lai K.C., A patient with long-standing iron-deficient anemia, Nature Clinical Practice. Gastroenterology & Hepatology. 2006, 3(2): 112-116.

 

Chan O.O., Hui W.M., Chan C.K., Lai K.C., Hu H.C., Yuen R.M.F., Wong R.W.M., Lau G., Hui C.K., Lam S.K. and Wong B.C.Y., Colonoscopy Demand and Practice in a Regional Hospital over 9 Years in Hong Kong: Resource Implication for Cancer Screening, Gastroenterology. 2006, 130 (4 Suppl 2): A-618.

 

Chan O.O., Hui W.M., Chan C.K., Lai K.C., Hu H.C., Yuen R.M.F., Wong R.W.M., Lau G., Hui C.K., Lam S.K. and Wong B.C.Y., Colonoscopy demand and practice in a regional hospital over 9 years in Hong Kong: Resource implication for cancer screening, Digestion. 2006, 73(2-3): 84-88.

 

Chan O.O., Cheng C., Hui W.M., Hu H.C., Wong Y.H., Lam K.F., Wong R.W.M., Lai K.C., Lam S.K. and Wong B.C.Y., Differing coping mechanisms, stress level and anorectal physiology in patients with functional constipation, World Journal of Gastroenterology. The WJG Press and Elsevier Inc., 2005, 11(34): 5362-5366.

 

Chan O.O., Peng J., Lam S.K., Lai K.C., Yuen R.M.F., Cheung K.L., Kwong Y.L., Rashid A., Chan C.K. and Wong B.C.Y., Eradication of Helicobacter pylori Infection Reverses E-cadherin Promoter Hypermethylation, Gut. 2006, 55: 463-468.

 

Chan O.O., Jim M.H., Lam K.F., Siu D.C.W., Tong S.M., Ng F.H., Hui W.M., Chan C.K., Lai K.C., Hu H.C., Yuen R.M.F., Lau Y.K., Lee S.W.L., Lam S.K. and Wong B.C.Y., Patients with Coronary Artery Disease are at High Risk for Developing Colorectal Cancer and Adenoma: An Interim Analysis of a Prospective Study, Gastroenterology. 2006, 130 (4 Supp 2): A-36.

 

Chan O.O., Lam K.F., Hui W.M., Hu W.H., Li J., Lai K.C., Chan C.K., Yuen R.M.F., Lam S.K. and Wong B.C.Y., Validated questionnaire on diagnosis and symptom severity for functional constipation in the Chinese population, Alimentary Pharmacology and Therapeutics. Blackwell Publishing Ltd, 2005, 22: 483-488.

 

Gu Q., Xia H.H.X., Wang J., Wong R.W.M., Chan O.O., Lai K.C., Chan C.K., Yuen R.M.F., Fung F.M.Y., Wong K.W., Lam S.K. and Wong B.C.Y., Update on clarithromycin resistance in Helicobacter pylori in Hong Kong and its effect on clarithromycin-based triple therapy., Digestion. 2006, 72(2-3): 101-106.

 

Gu Q., Xia H.H.X., Wang J., Chan O.O., Lai K.C., Fung F.M.Y., Wong K.W., Cheung K.L., Kung H. and Wong B.C.Y., Update on clarithromycin resistance in Helicobacter pylori in Hong Kong and its effect on clarithromycin-based triple therapy., In: Gu Q, Xia HHX, Wang JD, Chan AOO, Lai KC, Chan CK, Yuen MF, Fung FMY, Wong KW, Cheung HKL, H.F. Kung HF, B.C.Y. Wong BCY.. , J Gastroenterol Hepatol . 2005, 20 (Suppl.): A160.

 

Lai K.C., Chu K.M., Hui W.M., Wong B.C.Y., Hu H.C., Wong W.M.R., Chan O.O.A., Wong J. and Lam S.K., Celecoxib compared with lansoprazole and naprosyn to prevent gastrointestinal ulcer complications, American Journal of Medicine. 2005, 118: 1271-1278.

 

Ng W., Wong R.W.M., Chen W.H., Tse H.F., Lee P.Y., Lai K.C., Li L.S.W., Ng M.M.T., Lam K.F., Cheng X. and Lau C.P., Incidence and predictors of upper gastrointestinal bleeding in patients receiving low-dose aspirin for secondary prevention of cardiovascular events in patients with coronary artery disease, World Journal of Gastroenterology. Beijing, China, The WJG Press, 2006, 12(18): 2923-2927.

 

Wong W.M.R., Gu Q., Chu K.M., Yee Y.K., Fung F.M.Y., Tong S.M., Chan O.O.A., Lai K.C., Chan C.K. and Wong B.C.Y., Lansoprazole, levofloxacin and amoxicillin triple therapy versus quadruple therapy as second-line treatment of resistant Helicobacter pylori infection, Alimentary Pharmacology & Therapeutics. 2006, 23: 421-427.

 

Xia B., Xia H.H.X., Ma C.W., Wong K.W., Fung F.M.Y., Hui C.K., Chan C.K., Chan O.O., Lai K.C., Yuen R.M.F. and Wong B.C.Y., Trends in the prevalence of peptic ulcer disease and Helicobacter pylori infection in family physician-referred uninvestigated dyspeptic patients in Hong Kong. , Alimentary Pharmacology and Therapeutics. 2005, 22(3): 243-9.

 

Xia H.H.X., Wong R.W.M., Chan O.O., Lam S.K., Lai K.C., Chan C.K., Cheung K.L., Fung F.M.Y., Wong K.W. and Wong B.C.Y., Natural acquisition of Helicobacter pylori in adult dyspeptic patients with or without previous infection – a 7-year follow-up study. Australian Gastroenterology Week 2005, 19 October 2005, Australia. , Journal of Gastroenterology and Hepatology. 2005, 20: Supp A112.

 

Yuen R.M.F., Yuan H., Wong D.K.H., Yuen J.C.H., Wong R.W.M., Chan O.O., Wong B.C.Y., Lai K.C. and Lai C.L., Prognostic determinants for chronic hepatitis B in Asians: therapeutic implications. , Gut. 2005, 54(11): 1610-4.

 

Researcher : Lai KC



List of Research Outputs

 

Chan O.O. and Lai K.C., A patient with long-standing iron-deficient anemia, Nature Clinical Practice. Gastroenterology & Hepatology. 2006, 3(2): 112-116.

 

Chan O.O., Hui W.M., Chan C.K., Lai K.C., Hu H.C., Yuen R.M.F., Wong R.W.M., Lau G., Hui C.K., Lam S.K. and Wong B.C.Y., Colonoscopy Demand and Practice in a Regional Hospital over 9 Years in Hong Kong: Resource Implication for Cancer Screening, Gastroenterology. 2006, 130 (4 Suppl 2): A-618.

 

Chan O.O., Hui W.M., Chan C.K., Lai K.C., Hu H.C., Yuen R.M.F., Wong R.W.M., Lau G., Hui C.K., Lam S.K. and Wong B.C.Y., Colonoscopy demand and practice in a regional hospital over 9 years in Hong Kong: Resource implication for cancer screening, Digestion. 2006, 73(2-3): 84-88.

 

Chan O.O., Cheng C., Hui W.M., Hu H.C., Wong Y.H., Lam K.F., Wong R.W.M., Lai K.C., Lam S.K. and Wong B.C.Y., Differing coping mechanisms, stress level and anorectal physiology in patients with functional constipation, World Journal of Gastroenterology. The WJG Press and Elsevier Inc., 2005, 11(34): 5362-5366.

 

Chan O.O., Peng J., Lam S.K., Lai K.C., Yuen R.M.F., Cheung K.L., Kwong Y.L., Rashid A., Chan C.K. and Wong B.C.Y., Eradication of Helicobacter pylori Infection Reverses E-cadherin Promoter Hypermethylation, Gut. 2006, 55: 463-468.

 

Chan O.O., Jim M.H., Lam K.F., Siu D.C.W., Tong S.M., Ng F.H., Hui W.M., Chan C.K., Lai K.C., Hu H.C., Yuen R.M.F., Lau Y.K., Lee S.W.L., Lam S.K. and Wong B.C.Y., Patients with Coronary Artery Disease are at High Risk for Developing Colorectal Cancer and Adenoma: An Interim Analysis of a Prospective Study, Gastroenterology. 2006, 130 (4 Supp 2): A-36.

 

Chan O.O., Lam K.F., Hui W.M., Hu W.H., Li J., Lai K.C., Chan C.K., Yuen R.M.F., Lam S.K. and Wong B.C.Y., Validated questionnaire on diagnosis and symptom severity for functional constipation in the Chinese population, Alimentary Pharmacology and Therapeutics. Blackwell Publishing Ltd, 2005, 22: 483-488.

 

Gu Q., Xia H.H.X., Wang J., Wong R.W.M., Chan O.O., Lai K.C., Chan C.K., Yuen R.M.F., Fung F.M.Y., Wong K.W., Lam S.K. and Wong B.C.Y., Update on clarithromycin resistance in Helicobacter pylori in Hong Kong and its effect on clarithromycin-based triple therapy., Digestion. 2006, 72(2-3): 101-106.

 

Gu Q., Xia H.H.X., Wang J., Chan O.O., Lai K.C., Fung F.M.Y., Wong K.W., Cheung K.L., Kung H. and Wong B.C.Y., Update on clarithromycin resistance in Helicobacter pylori in Hong Kong and its effect on clarithromycin-based triple therapy., In: Gu Q, Xia HHX, Wang JD, Chan AOO, Lai KC, Chan CK, Yuen MF, Fung FMY, Wong KW, Cheung HKL, H.F. Kung HF, B.C.Y. Wong BCY.. , J Gastroenterol Hepatol . 2005, 20 (Suppl.): A160.

 

Lai K.C., Chu K.M., Hui W.M., Wong B.C.Y., Hu H.C., Wong W.M.R., Chan O.O.A., Wong J. and Lam S.K., Celecoxib compared with lansoprazole and naprosyn to prevent gastrointestinal ulcer complications, American Journal of Medicine. 2005, 118: 1271-1278.

 

Ng W., Wong R.W.M., Chen W.H., Tse H.F., Lee P.Y., Lai K.C., Li L.S.W., Ng M.M.T., Lam K.F., Cheng X. and Lau C.P., Incidence and predictors of upper gastrointestinal bleeding in patients receiving low-dose aspirin for secondary prevention of cardiovascular events in patients with coronary artery disease, World Journal of Gastroenterology. Beijing, China, The WJG Press, 2006, 12(18): 2923-2927.

 

Wong W.M.R., Gu Q., Chu K.M., Yee Y.K., Fung F.M.Y., Tong S.M., Chan O.O.A., Lai K.C., Chan C.K. and Wong B.C.Y., Lansoprazole, levofloxacin and amoxicillin triple therapy versus quadruple therapy as second-line treatment of resistant Helicobacter pylori infection, Alimentary Pharmacology & Therapeutics. 2006, 23: 421-427.

 

Xia B., Xia H.H.X., Ma C.W., Wong K.W., Fung F.M.Y., Hui C.K., Chan C.K., Chan O.O., Lai K.C., Yuen R.M.F. and Wong B.C.Y., Trends in the prevalence of peptic ulcer disease and Helicobacter pylori infection in family physician-referred uninvestigated dyspeptic patients in Hong Kong. , Alimentary Pharmacology and Therapeutics. 2005, 22(3): 243-9.

 

Xia H.H.X., Wong R.W.M., Chan O.O., Lam S.K., Lai K.C., Chan C.K., Cheung K.L., Fung F.M.Y., Wong K.W. and Wong B.C.Y., Natural acquisition of Helicobacter pylori in adult dyspeptic patients with or without previous infection – a 7-year follow-up study. Australian Gastroenterology Week 2005, 19 October 2005, Australia. , Journal of Gastroenterology and Hepatology. 2005, 20: Supp A112.

 

Yuen R.M.F., Yuan H., Wong D.K.H., Yuen J.C.H., Wong R.W.M., Chan O.O., Wong B.C.Y., Lai K.C. and Lai C.L., Prognostic determinants for chronic hepatitis B in Asians: therapeutic implications. , Gut. 2005, 54(11): 1610-4.

 

Researcher : Lai KN



Project Title:

Chemokine production and T cell interaction in chronic glomerulo-nephritides and interstitial nephritis: exploration of tubulo-glomerular communication

Investigator(s):

Lai KN, Leung JCK, Tang S.C.W.

Department:

Medicine

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

10/2003

Completion Date:

09/2006

 

Abstract:

To study tubulo-glomerular crosstalk in the presence of proteinuria. Activated PTEC induce proliferation and matrix formation in mesangial cells via soluble factors (alone or with participation of infiltrating T cells/monocytes); to determine whether PTEC may undergo epithelial-mesenchymal transidfferentiation under the influence of glomerulopathic proteins (alone or with participation of infiltrating T cells/monocytes); to examine whether activated mesangial cells (HMC) induce tubular expression of proinflammatory mediators (complement, chemokine, and growth factor) and the subsequent development of tubular epithelial-mesenchymal transdifferentiation via soluble factors (alone or with participation of infiltrating T cells/monocytes).

 

Project Title:

The role of the renin-angiotensin system in the tubulointerstitial injury of IgA nephropathy (IgAN)

Investigator(s):

Lai KN, Leung JCK

Department:

Medicine

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

02/2004

 

Abstract:

To define the role of RAS in inducing PTEC/MC damage and; to elucidate the cross-talk between resident cells and infiltrating cells (T-cells/monocytes).

 

Project Title:

The role of the renin-angiotensin system in the tubulointerstitial injury of IgA nephropathy (IgAN)

Investigator(s):

Lai KN

Department:

Medicine

Source(s) of Funding:

Merit Award for RGC CERG Funded Projects

Start Date:

01/2005

 

Abstract:

N/A

 

Project Title:

The role of the renin-angiotensin system in the tubulointerstitial injury of IgA nephropathy (IgAN)

Investigator(s):

Lai KN, Leung JCK

Department:

Medicine

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

01/2005

 

Abstract:

To determine whether there are known IgA receptors in the renal tubules; to determine the presence of any specific binding of pIgA from patients with IgAN to renal tubular epithelial cells; if there is no specific binding of IgA from IgAN to renal tubular epithelial cells, to find out where there are humoral or soluble factors from activated mesangial cells that induce tubular expression of proinflammatory mediators and the subsequent development of tubular epithelial-mesenchymal transdifferentiation; to explore which receptors for these proinflammatory mediators are present in renal tubules; to find out whether tubular damage is mediated via soluble factors alone or infiltrating T-cells/monocytes are also required.

 

Project Title:

Development of monoclonal antibodies against SARS-associated coronavirus: specific targeting for early diagnosis and future treatment

Investigator(s):

Lai KN, Kwong YL, Chung SSM

Department:

Medicine

Source(s) of Funding:

Research Fund for the Control of Infectious Diseases - Full Grants

Start Date:

01/2005

Completion Date:

09/2006

 

Abstract:

In this project, we propose to express the coronaviral proteins in vitro. B lymphocytes from patients with immunity to the coronavirus will be used to produce specific antibodies against coronaviral anitgens. These monoclonal antibodies will be of tremendous value in providing a safe and rapid serum and tissue diagnosis of SARS-related coronavirus infection. Therapeutic potentials are also possible for these antibodies as an adjuvant immuno-modulatory therapy.

 

Project Title:

Crosstalk between Podocytes and Mesangial Cells in IgAN

Investigator(s):

Lai KN

Department:

Medicine

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

03/2006

 

Abstract:

IgA nephropathy (IgAN) is the major leading cause of kidney failure worldwide. The disease is characterized by the deposition of "pathogenetic" polymeric immunoglobulin A (pIgA) in the glomerular mesangium followed by proliferation of the mesangial cell (HMC) and infiltration of immunocompetent cells including T-cells and monocytes. [1] IgAN runs a highly variable clinical course that is often associated with progressive tubulointerstitial damage and subsequent renal failure. The severity of tubulo- interstitial damage is a better prognostic indicator of renal function than glomerular sclerosis, yet IgA deposits are seldom detected in the tubulointerstitium. Although high-grade proteinuria can lead to tubulointerstitial damage and progressive kidney failure in glomerular disease, heavy proteinuria, notably, is not a common feature of IgAN. Hence, the puzzling question is how do IgA deposits in glomerular mesangial cells lead to subsequent tubulointerstitial damage and result in terminal renal failure. Although the causes of kidney failure are diverse, the glomerular filtration barrier is often the target of injury. This barrier separates the blood from urinary spaces, and selectivity permits the removal of excess water and solute while preventing the loss of critical blood proteins such as albumin, immunoglobulins and clotting factors. The filtration barrier consists of glomerular visceral epithelial cells (podocytes) that are in intimate association with fenestrated glomerular capillary endothelial cells, and are separated from each other by a thin glomerular basement membrane (GBM) that measures only 0.3 micron. Glomerular podocytes are highly differentiated cells that play a key role in maintaining the integrity of the glomerular filtration barrier. Their interdigitating foot processes cover the exterior surface of the glomerular basement membrane and, in turn, stabilize the glomerular architecture. In glomerular diseases, podocyte damage is associated with proteinuria and progressive loss of kidney function. [2] Recent genetic studies have highlighted the importance of the podocyte in disease processes that affect the glomerulus. A number of podocyte proteins have been identified and genetic mutations of these podocyte proteins are associated with congenital forms of nephrotic syndrome.[3,4] These genetic breakthroughs have stimulated renewed interest in glomerular epithelial cell biology, both in normal, congenital and acquired disease states. As a consequence of the high degree of differentiation of podocytes in analogy to neurons, these cells are unable to proliferate. An inability to repopulate a damaged glomerulus with functional podocytes corresponds with the progressive ultrastructural lesions seen in podocyte during filtration barrier failure. Investigators from Hong Kong first reported necrosis and detachment of the podocytes from the GBM in IgAN in 1984.[5] Subepithelial accumulation of proteinaceous material from the mesangium leads to degeneration and exfoliation of podocytes. [6] Those IgAN patients with the most severe glomerular dysfunction have a reduced number of podocytes per glomerulus. [7] The degree of podocytopenia is related to the extent of glomerular sclerosis and of impairment of permeability and glomerular filtration rate. Urinary excretion of podocytes is increased in IgAN [8] and this observation complements the histologic finding of podocytopenia. The urinary excretion of podocytes reflects disease activity and the excretion decreases following treatment with either angiotensin-converting enzyme (ACE) inhibitors or statins. [9,10] Despite IgAN being the most common glomerulonephritis worldwide and the abundance of literature on the structural and immunoregulatory abnormalities in IgAN, information on podocyte biology in IgAN is scarce. Our research proposal will examine the following issues: (i) Is there a specific binding of pIgA from patients with IgAN to podocytes? (ii) How does mesangial deposition of IgA lead to glomerular filtration barrier failure in IgAN? Hypothesis and Specific Aims: Our working hypothesis is that the natural progression of tubulointerstitial injury in IgAN is mediated through a "glomerulo-tubular" cross-talk. We postulate that soluble factors are released from glomerular mesangial cells following initial deposition of "pathogenetic" pIgA. A cross-talk network initiated by these soluble factors will orchestrate interactions between infiltrating immunocompetent cells and the resident renal cells, forming a major driving force of tubulointerstitial injury. These humoral factors from mesangial cells (HMC) may reach the tubulointerstitium either by glomerular filtration or by transportation via the post-glomerular capillaries. Podocytes in the Bowen's capsule must play a pivotal controlling role of the traffic of these humoral factors between the glomerular mesangial cells and tubular epithelial cells. We hypothesize that functional and structural changes occur to podocytes in IgAN and thus lead to dysfunction of the filtration barrier. Our present proposal will examine functional and structural abnormalities of podocytes following mesangial IgA deposition. The research also aims to dissect the interaction between podocytes and other renal resident cells in IgAN. References 1. Lai KN, Chan LY, Leung JC: Kidney Int Suppl 2005:S110-115. 2. Kriz W: Pediatr Nephrol 2003; 18: 617-622 3. Kestila M, Lenkkeri U, Mannikko M, et al: Mol Cell 1998; 1: 575-582. 4. Boute N, Gribouval O, Roselli S: Nat Genet 2000; 24: 349-354. 5. Ng WL, Chan KW, Yeung CK, Kwan S: Pathology 1984; 16: 324-330. 6. Shigematsu H, Kobayashi Y, Hiki Y: Ultrastruct Pathol 1990; 14: 129-139. 7. Lemley KV, Lafayette RA, Safai M, et al: Kidney Int 2002; 61: 1475-1485. 8. Hara M, Yanagihara T, Takada T, et al: Am J Nephrol 1998; 18: 35-41. 9. Nakamura T, Ushiyama C, Suzuki C, et al: Am J Nephrol 2000; 20: 373-373339. 10. Nakamura T, Ushiyama C, Hirokawa K, et al: Nephrol Dial Transplant 2002; 17: 798-802.

 

List of Research Outputs

 

Chan L.Y., Leung J.C.K., Tang S.C.W. and Lai K.N., Glucose modulates leptin and adiponectin synthesis by human peritoneal omental adipocyte, Journal of American Society of Nephrology. 2005, 16: 791A.

 

Chan L.Y., Leung J.C.K., Tang S.C.W., Choy C.B.Y. and Lai K.N., Tubular expression of angiotensin II receptors and their regulation in IgA nephropathy, Journal of American Society of Nephrology. 2005, 16(8): 2306-2317.

 

Choy C.B.Y., Chan D.T.M., Tse K.C., Lam M.F. and Lai K.N., Mycophenolic acid increase risk of herpes zoster infection in renal transplant recipients, Journal of American Society of Nephrology. 2005, 16: 835A.

 

Guo H., Leung J.C.K., Chan L.Y., Lui S.L., Tsang W.L. and Lai K.N., Modulation of intra-pulmonary TGF-beta expression by mycophenolate mofetil in lupus prone MRL/lpr mice, Lupus. 2005, 14(8): 583-592.

 

Lai A.S. and Lai K.N., Molecular basis of IgA nephropathy, Current Molecular Medicine. 2005, 5(5): 475-487.

 

Lai A.S. and Lai K.N., Viral nephropathy, Nature Clinical Practice. Nephrology. 2006, 2(5): 254-262.

 

Lai K.N., Associate Editor, American Journal of Kidney Diseases. 2005.

 

Lai K.N., Chapter: "IgA nephropathy", In: Kurma and Clark, Online appendix in Textbook of Medicine, 6th Edition. Edinburgh, Elservier Saunders, 2005.

 

Lai K.N., Chapter: "Severe acute respiratory syndrome", In: Kurma and Clark, Online appendix in Textbook of Medicine, 6th Edition. Edinburgh, Elservier Saunders, Edinburgh, 2005.

 

Lai K.N., Chan L.Y., Tang S.C.W. and Leung J.C.K., Ganoderma extract prevents albumin-induced oxidative damage and chemokines synthesis in cultured human proximal tubular epithelial cells, Nephrology Dialysis Transplantation. 2006, 21(5): 1188-1197.

 

Lai K.N., Managing Editor, Nephrology [Blackwell]. 2005.

 

Lai K.N., Tang S.C.W., Chan L.Y. and Leung J.C.K., Monocytes/T cells modulate chemokine release and chemokine receptor expression in proximal tubular epithelial cells in proteinuric state, Journal of American Society of Nephrology. 2005, 16: 642A.

 

Lai K.N., Outstanding Research Student Supervisor Award, Excellence in Teaching and Research 2005, The University of Hong Kong. 2005.

 

Lai K.N., Pathogenic IgA in IgA nephropathy: still the blind men and the elephant?, Kidney International. 2006, 69(7): 1102-1103.

 

Lai K.N., Viral-induced acute renal failure, Acute renal failure from bench to bedside: 3rd World Congress of Nephrology Post-Congress Satellite Symposium, Penang, Malaysia, July 1-3. 2005.

 

Lam M.F., Leung J.C.K., Lo W.K., Lui S.L., Chan D.T.M. and Lai K.N., Increased serum leptin levels during peritoneal dialysis related peritonitis associated with prolonged inflammation and loss of lean body mass, Journal of American Society of Nephrology. 2005, 16: 713A.

 

Lam M.F., Leung J.C.K., Tang C.S.O., Lo W.K., Tse K.C., Yip T.P.S., Lui S.L., Chan D.T.M. and Lai K.N., Mannose binding lectin level and polymorphism in patients on long-term peritoneal dialysis, Nephrology Dialysis Transplantation. 2005, 20: 2489-2496.

 

Leung A.Y.H., Leung J.C.K., Chan Y.Y., Ma E.S.K., Kwan T.F., Lai K.N., Meng A. and Liang R.H.S., Proliferating cell nuclear antigen (PCNA) as a proliferative marker during embryonic and adult zebrafish hematopoiesis, Histochemistry and Cell Biology. 2005, 124(2): 105-11.

 

Leung J.C.K., Chan L.Y., Li F.K., Tang S.C.W., Chan K.W., Chan D.T.M., Lam M.F., Wieslander A. and Lai K.N., Glucose degradation products downregulate ZO-1 expression in human peritoneal mesothelial cells: the role of VEGF, Nephrology Dialysis Transplantation. 2005, 20(7): 1336-1349.

 

Leung J.C.K., Chan L.Y., Tang S.C.W. and Lai K.N., Glycosylation profile of anionic polymeric IgA and their binding characteristics to cultured mesangial cells in IgA nephropathy, Journal of American Society of Nephrology. 2005, 16: 49A.

 

Leung J.C.K., Chan Y.Y., Tang S.C.W., Chu K.M. and Lai K.N., Leptin induces TGF-b synthesis through functional leptin receptor expressed by human peritoneal meoshtelial cell, Kidney International. 2006, 69: 2078-2086.

 

Lui S.L., Cheng S.W., Ng F.S.K., Ng S.Y., Wan K.M., Yip T., Tse K.C., Lam M.F., Lai K.N. and Lo W.K., Cefazolin plus netilmicin versus cefazolin plus ceftazidime for treating CAPD peritonitis: effect on residual renal function, Kidney International. 2005, 68(5): 2375-2380.

 

Lui S.L., Chan K.W., Tsang R.C.W., Yung S.S.Y., Lai K.N. and Chan D.T.M., Effect of rapamycin on renal ischemia reperfusion injury, Joint symposium on extracorporeal support for multi-organ failure organized by Hong Kong College of Physicians Scientific Symposium and Hong Kong Society of Nephrology Annual Scientific Meeting, 10-11 September 2005, Hong Kong. 2005.

 

Lui S.L., Yip T., Tse K.C., Lam M.F., Lai K.N. and Lo W.K., Treatment of refractory pseudomonas aeruginosa exit-site infection by simultaneous removal and reinsertion of peritoneal dialysis catheter, Peritoneal Dialysis International. 2005, 25(6): 560-563.

 

Tang S., Lai F.M., Lui R.Y.H., Tang C.S.O., Kung N.N.S., Ho Y.W., Chan K.W., Leung J.C.K. and Lai K.N., Lamivudine in hepatitis B-associated membranous nephropathy, Joint symposium on extracorporeal support for multi-organ failure organized by Hong Kong College of Physicians Scientific Symposium and Hong Kong Society of Nephrology Annual Scientific Meeting, 10-11 September 2005, Hong Kong. 2005.

 

Tang S.C.W., Leung J.C.K., Chan L.Y., Tsang W.L. and Lai K.N., Activation of tubular epithelial cells in diabetic nephropathy and the role of the peroxisome proliferator-activated receptor-gamma agonist, Journal of American Society of Nephrology. 2006, 17(6): 1633-1643.

 

Tang S.C.W. and Lai K.N., Chapter : "Glomerulonephritis", In: T.M. Chan and M.K. Chan, Integrated Systemic Nephrology, 3rd Edition. Hong Kong, The University of Hong Kong, 2006, 63-70.

 

Tang S.C.W. and Lai K.N., Chapter : "Hypertension and the kidney", In: T.M. Chan and M.K. Chan, Integrated Systemic Nephrology, 3rd Edition. Hong Kong, The University of Hong Kong, 2006, 93-102.

 

Tang S.C.W. and Lai K.N., Chapter : "Some specific glomerulonephritides", In: T.M. Chan and M.K. Chan, Integrated Systemic Nephrology, 3rd Edition. Hong Kong, The University of Hong Kong, 2006, 71-80.

 

Tang S.C.W., Lam B., Leung H., Ip M.S.M. and Lai K.N., Impact of nocturnal peritoneal dialysis on the severity of sleep apnoea and the duration of hypoxemia during sleep: A cross-over study, Journal of American Society of Nephrology. 2005, 16: 852A.

 

Tang S.C.W., Lai F.M., Lui Y.H., Tang C.S.O., Kung N.N., Ho Y.W., Chan K.W., Leung J.C.K. and Lai K.N., Lamivudine in hepatitis B-associated membranous nephropathy, Kidney International. 2005, 68(4): 1750-1758.

 

Tang S.C.W., Leung J.C.K., Chan L.Y., Lui Y.H., Tang C.S.O., Kan C.H., Ho Y.W. and Lai K.N., Mycophenolate mofetil alleviates persistent proteinuria in IgA nephropathy, Kidney International. 2005, 68(2): 802-812.

 

Tang S.C.W., Ho Y.W., Leung J.C.K. and Lai K.N., Mycophenolate mofetil in the treatment of steroid-resistant primary focal segmental glomerulosclerosis, Journal of Nephrology. 2005, 18(4): 429-432.

 

Tang S.C.W., Leung J.C.K., Chan L.Y., Tsang W.L. and Lai K.N., Role of PPAR-g agonist in diabetic nephropathy: An in vivo study, Journal of American Society of Nephrology. 2005, 16: 613A.

 

Tang S.C.W., Ho Y.W., Chan C.S. and Lai K.N., Rupture of the left kidney, American Journal of Kidney Diseases. 2006, 47(2): A31, e21-2.

 

Tse K.C., Tang S.C.W., Tang C.S.O., Lai K.N., Li F.K. and Chan D.T.M., Angiotensin inhibition or blockade for the treatment of patients with quiescent lupus nephritis and persistent proteinuria, Lupus. 2005, 14(12): 947-952.

 

Wang A.Y.M. and Lai K.N., The importance of residual renal function in dialysis patients, Kidney International. 2006, 69(10): 1726-1732.

 

Xia Y., Li Y., Du Y., Yang N., Li C., Leung J.C.K., Lam M.F., Huang W., Chen S., Maxwell P.H., Lai K.N. and Wang Y.M., Association of MEGSIN 2093C-2180T haplotype at the 3' untranslated region with disease severity and progression of IgA nephropathy, Nephrology Dialysis Transplantation. 2006, 21(6): 1570-1574.

 

Yip T.P.S., Tse K.C., Lam M.F., Tang S.C.W., Li F.K., Choy C.B.Y., Lui S.L., Chan D.T.M., Lai K.N. and Lo W.K., Risk factors and outcomes of extended-spectrum beta-lactamase-producing E. coli peritonitis in CAPD patients, Peritoneal Dialysis International. 2006, 26(2): 191-197.

 

Zhong Q., Leung J.C.K., Chan L.Y., Tsang W.L., Chen X. and Lai K.N., The study of Chinese medicinal herbal formula Shen San Fang in the treatment of experimental IgA nephropathy, the American Journal Of Chinese Medicine. 2005, 33(4): 613-626.

 

Researcher : Lai KWH



List of Research Outputs

 

Wang K., Xue T., Tsang S.Y., Huizen R.V., Wong C.W., Lai K.W.H., Ye Z., Cheng L., Zhang J.C.L., Li G.R., Lau C.P., Tse H.F. and Li R.A., Electrophysiological Properties of Pluripotent Human and Mouse Embryonic Stem Cells, Stem Cells. 2005, 23: 1526-1534.

 

Researcher : Lai MH



List of Research Outputs

 

Cheung C.L., Ng W.W., Lai M.H., Chan V.N.Y. and Kung A.W.C., Association of a single nucleotide polymorphism in low-density lipoprotein receptor-related protein 5 (LRP5) gene promoter region with peak bone mineral density: A case-control study, 27th Annual Meeting of the American Society for Bone & Mineral Research, 23-27 September 2005, Nashville, USA. 2005.

 

Gu J., Lai M.H., Chan V.N.Y. and Kung A.W.C., Association of estrogen receptor beta gene polymorphisms and rate of bone loss in perimenopausal women, 27th Annual Meeting of the American Society for Bone & Mineral Research, 23-27 September 2005, Nashville, USA. 2005.

 

Kung A.W.C., Lai M.H., Ng M.Y.M., Cheung W.M.W., Chan V.N.Y. and Sham P.C., Estrogen receptor beta polymorphisms predict risks of osteoporosis in men and women: A linkage and association study, 27th Annual Meeting of the American Society for Bone & Mineral Research, 23-27 September 2005, Nashville, USA. 2005.

 

Kung A.W.C., Lai M.H., Ng M.Y.M., Chan V.N.Y. and Sham P.C., T-1213C polymorphism of estrogen receptor beta is associated with low bone mineral density and osteoporotic fractures, Bone. 2006.

 

Lai M.H. and Kung A.W.C., Dinucleotide CA repeat polymorphisms in ESR1 gene are associated with increased risk of low BMD and osteoporotic fractures, 27th Annual Meeting of the American Society for Bone & Mineral Research, 23-27 September 2005, Nashville, USA. 2005.

 

Lai M.H., Luk K.D.K. and Kung A.W.C., ESR1 CA(n) repeat polymorphism is associated with increased risk of osteoporotic fractures and estrogen receptor alpha: mrna expression in bone, The IOF World Congress on Osteoporosis, 2-6 June 2006, Toronto, Canada. 2006.

 

Researcher : Lam B



List of Research Outputs

 

Chow W.S., Tan K.C.B., Lam J.C.M., Lam B., Bucala R., Betteridge D.J. and Ip M.S.M., Advanced glycation end products are increased in non-diabetic patients with obstructive sleep apnea but to a lesser degree than type 2 diabetic patients, 11th Medical Research Conference of Department of Medicine, HKU. 2006.

 

Kwong Y.L., Lau W.C.S., Ho S.L., Epstein R., Young R.T.T., Chan H.H.L., Tse H.F., Lam L., Chen W.H., Lee K.L.F., Ip M.S.M., Tsang K.W.T., Lam B., Tang S.C.W., Chan R.H.W., Lee S.W.L., Tan K.C.B., Yeung C.K., Chan D.T.M., Wong R.W.S., Choy C.B.Y., Wong B.C.Y., Li F.K., Lo W.K., Lui S.L., Cheung R.T.F., Mak W., Ho J.C.M., Mok T.M.Y., Kung A.W.C., Cheung B.M.Y., Chow W.S., Yuen R.M.F. and Wat N.M.S., In: Lau CP, Kumana CR, Lai CL, Lai KN, Lam KSL, Lam WK, Problem-Based Medical Case Management. Hong Kong, Hong Kong University Press, 2005.

 

Lam B., Tam C.M., Lam S.Y., Wong M.P., Ooi C.G.C., Fung S.L., Lam D.C.L., Ip M.S.M. and Lam W.K., Detection of early lung cancer in high risk population: A prospective study. 11th World Conference on Lung Cancer, Lung Cancer. 2005, 49 (Suppl 2): S182 (P-257).

 

Lam B., Wong M.P., Fung S.L., Lam D.C.L., Wong P.C., Mok T.Y.W., Lam F.M., Ip M.S.M., Ooi C.G.C. and Lam W.K., The clinical value of autofluorescence bronchoscopy for the diagnosis of lung cancer, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2006, Abstract Book 094: pp. 58.

 

Lam J.C.M., Lam B., Tang S.C.W. and Ip M.S.M., A sleep study with positional hypoxemia, Sleep Medicine. 2006, 7: 383-384.

 

Lam J.C.M., Lam B., Lam C.L., Fong D.Y.T., Wang J., Tse H.F., Lam K.S.L. and Ip M.S.M., Obstructive sleep apnoea and the metabolic syndrome in community based Chinese adults in Hong Kong, Respiratory Medicine. 2006, 100: 980-987.

 

Lam J.C.M., Lam B., Lam C.L.K., Fong D.Y.T., Wang J.K.L., Tse H.F., Lam K.S.L. and Ip M.S.M., Obstructive sleep apnoea and the metabolic syndrome in community-based, Chinese Adults in Hong Kong Resp Med . 2006, 100: 980-987.

 

Luk J.M.C., Chen L., Lam B., Ho D., Peng J., Leng J., Leng X., Hui C.K., Lau G., Yip T.T. and Fan S.T., Comparing serum alpha-fetoprotein level and SELDI-TOF-MS profilling for diagnosis of hepatocellular carcinoma. The 4th JSH Single Topic conference on hepatocellular carcinoma. , Hoyogo, Japan. 2005, Dec2-3, 05.

 

Ooi C.G.C., Ho J.C.M., Lam B., Lai A.Y.K., Tsang K.W.T. and Lam W.K., Relationship between MR intra-abdominal fat parameters and cardiovascular risk parameters in obstructive sleep apnoea, Respirology. 2005, 10 (Suppl): A176 (#366).

 

Sam K., Lam B., Ooi C.G.C., Cooke M.S. and Ip M.S.M., Effect of a fixed oral appliance on upper airway morphology in obstructive sleep apnea, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong, January 2006. Abstract Book 095: pp.59.

 

Sam K., Lam B., Ooi C.G.C., Cooke M.S. and Ip M.S.M., Effect of a non-adjustable oral appliance on upper airway morphology in obstructive sleep apnea, Respiratory Medicine. 2006, 100: 897-902.

 

Tan K.C.B., Chow W.S., Lam J.C.M., Lam B., Bucala R., Betteridge D.J. and Ip M.S.M., Advanced glycation end products are increased in non-diabetic patients with obstructive sleep apnea but to a lesser degree than type 2 diabetic patients, 41st European Association for the Study of Diabetes Annual Meeting, Athens, Sept 2005.

 

Tan K.C.B., Chow W.S., Lam J.C.M., Lam B., Bucala R., Betteridge D.J. and Ip M.S.M., Advanced glycation end products in non-diabetic patients with obstructive sleep apnea, Sleep . 2006, 29: 329-33.

 

Tan K.C.B., Chow W.S., Lam J.C.M., Lam B., Wong W.K., Tam S. and Ip M.S.M., HDL dysfunction in obstructive sleep apnea, Atherosclerosis. 2006, 184(2): 377-82.

 

Tang S.C.W., Lam B., Leung H., Ip M.S.M. and Lai K.N., Impact of nocturnal peritoneal dialysis on the severity of sleep apnoea and the duration of hypoxemia during sleep: A cross-over study, Journal of American Society of Nephrology. 2005, 16: 852A.

 

Yiu K.H., Miu R., Lee K.L.F., Yung L.Y., Siu C.W.D., Tse H.F., Lam B., Lam J., Ip M.S.M. and Lau C.P., Improvement of sleep Apnea in heart failure patients after cardiac resynchronization therapy is associated with a significant dop in pulmonary arterial pressure, Heart Rhythm. 2006, 3, No. 5: S87.

 

Yiu K.H., Lee K.L.F., Tse H.F., Siu C.W.D., Lam B., Ip M.S.M. and Lau C.P., Improvement of sleep apnea in heart failure patients after cardiac resynchronization therapy is caused by relief of pulmonary congestion as reflected by a drop of pulmonary arterial pressure, Europace. 2006, 10/6.

 

Yiu K.H., Miu K.M., Lee K.L.F., Tse H.F., Siu C.W.D., Lam K., Lam B., Ip M.S.M. and Lau C.P., Improvement of sleep apnea in heart failure patients after cardiac resynchronization therapy is caused by relief of pulmonary congestion sa reflected by a drop of pulmonary congestion as reflected by a drop of pulmonary arterial pressure, Europace . 2006, 8 Supplement 1: 10/6.

 

Researcher : Lam CLK



Project Title:

A randomised controlled trial on the effectiveness of screening and brief problem-solving counselling for elderly patients with undiagnosed psychological problems in primary care

Investigator(s):

Lam CLK, Fong DYT, Lam TP, Lee PWH

Department:

Med - Family Medicine Unit

Source(s) of Funding:

Health Care and Promotion Fund - Research Grant Projects

Start Date:

08/2002

Completion Date:

06/2006

 

Abstract:

To test if screening followed by brief problem-solving counselling by primary care doctors can improve the health-related quality of life (HRQOL) of elderly patients with previously undiagnosed psychological problems; to find out the effects of undiagnosed psychological problems on HRQOL and consultation rates of elderly patients.

 

Project Title:

Effectiveness of Traditional Chinese Medicine in Primary Care

Investigator(s):

Lam CLK, Wong Wendy, Zhao , Leung

Department:

Med - Family Medicine Unit

Source(s) of Funding:

Small Project Funding

Start Date:

12/2005

 

Abstract:

Primary health care has important contributions to the health of the population by managing over 90%of the illnesses of the population. Although Western medicine is the established system of health care in Hong Kong, 50 to 60% of people in Hong Kong have consulted Traditional Chinese medicine (TCM) practitioners and 13.5% of the people consult TCM frequently or occasionally (1). There are 7707 registered TCM practitioners serving a population of 6.8 million in Hong Kong, most of them provide primary care. Despite the popularity of TCM in primary care in Hong Kong, there are not many research data on its effectiveness. Evidence on the effectiveness of TCM is important to inform the public in their choice of primary care . The evaluation of the effectiveness of TCM needs to use appropriate outcome measures. The outcome measures of TCM should be coherent with its underlying philosophy and theory. Health related quality of life (HRQOL) is probably the most suitable outcome measure of TCM because it matches the latter's emphasis on the enhancement of physical, social and psychological well being. HRQOL has been shown to be a reliable and valid outcome measure of health, illness and treatment in Western medicine. It has also been used as an outcome measure in several TCM clinical trials on cancer, geriatrics, and rehabilitation (2-5). Most of the studies were able to show with HRQOL measures that TCM had an effect on patient's psychological well-being. However, many authors have raised the concern that HRQOL measures developed for Western medicine may not evaluate the effectiveness of TCM adequately because they do not capture all the health concept of TCM. A HRQOL measure specific to the concepts of TCM may be more sensitive and responsive to its treatment effects (5-7). The Chinese Quality of Life Instrument (ChQOL) was developed recently in China for assessing HRQOL based on the philosophy and theory of TCM. It is intended for the monitoring the patient's subjective perception during illness and treatment. The ChQOL has been validated and pilot tested on Chinese populations in Guangzhou and Hong Kong (8). Many Chinese medicine interventions have claimed to improve quality of life but few have been substantiated by research studies measuring HRQOL as the primary outcome and with standard validated measures. The aim of the present study is to evaluate the effectiveness of TCM in enhancing patients' quality of life in primary care by the use of a widely used generic and a TCM-specific HRQOL measures. The study would also determine the psychometric properties of these measures for the evaluation of the effectiveness of TCM in the primary care. Research objectives 1) To investigate whether TCM can improve HRQOL of patients in primary care. 2) To investigate the correlation between HRQOL evaluations and the clinical assessment by TCM practitioners. 3) To investigate whether a TCM specific HQOL measure is more sensitive and responsive than a generic HRQOL measure to evaluate the effectiveness of TCM.

 

Project Title:

A randomized, double blind, placebo-controlled clinical trial of Chinese herbal medicine in the treatment of acute upper respiratory infections

Investigator(s):

Lam CLK, Wong W, Fong DYT

Department:

Med - Family Medicine Unit

Source(s) of Funding:

Research Fund for the Control of Infectious Diseases - Full Grants

Start Date:

01/2006

 

Abstract:

The aim of this study is to test if Chinese herbal medicine (CHM) guided by Traditional Chinese medicine (TCM) diagnosis will significantly increase recovery rate, and reduce the duration and/or severity of symptoms, and improve the quality of life of patients with URTIs in primary care.

 

List of Research Outputs

 

Gandek B. and Lam C.L.K., Evaluating the SF-36V2 in Hong Kong., Quality of Life Research. 2005, 14(9): 2098.

 

Lam C.L.K., 17th Dr. Sun Yat Sen Oration "Life is Short, Art is Long"., Hong Kong College of Family Physicians. Hong Kong, 2006.

 

Lam C.L.K., Dr. Sun Yat Sen Oration - Life is short, art is long., Hong Kong Practitioner. 2006, 28: 266-271.

 

Lam C.L.K., Plenary Lecture on "家庭醫學專業資格評核" (Professional Assessment in Family Medicine)., Four Parties Conference on Family Medicine. 2006年海峽兩岸四地全科/家庭醫學學術大會, Beijing, 2006.

 

Lam C.L.K., Lecture on "Health-related Quality of Life - the Ultimate Health Outcome Measure"., Frontiers in Biomedical Research, The University of Hong Kong. Hong Kong, 2005.

 

Lam C.L.K., Symposium paper on "Equivalence in Cross-Cultural Health-Related Quality of Life (Hrqol) Measures"., Conference on Quality of Life Research in Asia. Hong Kong Society for Quality of Life. Hong Kong, 2006.

 

Lam C.L.K., Tse E.Y.Y., Gandek B. and Fong D.Y.T., The SF-36 Summary Scales is Valid, Reliable, and Equivalent in a Chinese Population, Journal of Clinical Epidemiology. 2005, 58(8): 815-822.

 

Lam C.L.K., The role of the family doctor in building a healthy tomorrow., Hong Kong Practitioner. 2005, 27: 363-367.

 

Lam C.L.K., Workshop on Consultation in Family Medicine. 第二届全國全科醫生骨幹短期培訓班. 衛生部全科醫學培訓中心 / 中國醫師協會全科醫師分會主辨, Hong Kong, 2005.

 

Lam J.C.M., Lam B., Lam C.L.K., Fong D.Y.T., Wang J.K.L., Tse H.F., Lam K.S.L. and Ip M.S.M., Obstructive sleep apnoea and the metabolic syndrome in community-based, Chinese Adults in Hong Kong Resp Med . 2006, 100: 980-987.

 

Lam S.P., Tsui E., Chan K.S., Lam C.L.K. and So H.P., The validity and reliability of the functional impairment checklist (FIC) in the evaluation of functional consequences of severe acute respiratory distress syndrome (SARS)., Quality of Life Research. 2006, 15: 217-231.

 

Law C.W., Chen E.Y.H., Cheung E.F.C., Chan R.C.K., Wong J.G.W.S., Lam C.L.K., Leung K.F. and Lo M.S.M., Impact of Untreated Psychosis on Quality of Life in Patients with First-episode Schizophrenia, Quality of Life Research. 2005, 14: 1803-1811.

 

McGhee S.M., Lam C.L.K., Lam T.P., Cheung B.M.Y., Schooling C.M. and McInnes G.T., An investigation into the current management of hypertension in Hong Kong: A two-phase study (Research dissemination report), Hong Kong Medical Journal. 2006, 12(2) Suppl 1: 24-27.

 

McMillan A.S., Wong M.C.M., Zheng J. and Lam C.L.K., Prevalence of oro-facial pain and treatment seeking in Hong Kong Chinese., Journal of Orofacial Pain. 2006, 20: 218-225.

 

Wong L.C., Lam C.L.K., Brazier J. and McGhee S.M., A utility measure algorithm from teh SR-36 in Hong Kong (Abstract), Hong Kong College of Community Medicine Annual Scientific Meeting, 25 June 2006, Hong Kong. Hong Kong, Hong Kong College of Community Medicine, 2006, Poster 5.

 

Wong O.L., Kuntz K.M., Cowling B.J., Lam C.L.K. and Leung G.M., Cost-effectiveness of mammograpny screening for Hong Kong Chinese women (Abstract), Hong Kong College of Community Medicine Annual Scientific Meeting, 25 June 2006, Hong Kong. Hong Kong, Hong Kong College of Community Medicine, 2006, Free paper 5.

 

Researcher : Lam CW



List of Research Outputs

 

Chen B., Lam K.S.L., Wang Y., Wu D., Lam C.W., Shen J., Wong L.C., Hoo R.L.C., Zhang J. and Xu A., Hypoxia dysregulates the production of adiponectin and plasminogen activator inhibitor-1 independent of reactive oxygen species in adipocytes, Biochem Biophys Res Commun. 2006, 341: 549-56.

 

Wang Y., Lam K.S.L., Chan L., Chan K.W., Lam J.B.B., Lam C.W., Hoo R.L.C., Mak W.W., Cooper G.J. and Xu A., Post-translational modifications of the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high molecular weight oligomeric complex, J Biol Chem. 2006, 281: 16391-400.

 

Wang Y., Lam K.S.L., Chan L., Chan K.W., Lam J.B.B., Lam C.W., Hoo R.L.C., Mak W.W., Cooper G.J.S. and Xu A., Posttranslational modifications on the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high-molecular-weight oligomeric complex, J Biol Chem. 2006.

 

Researcher : Lam CW



List of Research Outputs

 

Chen B., Lam K.S.L., Wang Y., Wu D., Lam C.W., Shen J., Wong L.C., Hoo R.L.C., Zhang J. and Xu A., Hypoxia dysregulates the production of adiponectin and plasminogen activator inhibitor-1 independent of reactive oxygen species in adipocytes, Biochem Biophys Res Commun. 2006, 341: 549-56.

 

Wang Y., Lam K.S.L., Chan L., Chan K.W., Lam J.B.B., Lam C.W., Hoo R.L.C., Mak W.W., Cooper G.J. and Xu A., Post-translational modifications of the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high molecular weight oligomeric complex, J Biol Chem. 2006, 281: 16391-400.

 

Wang Y., Lam K.S.L., Chan L., Chan K.W., Lam J.B.B., Lam C.W., Hoo R.L.C., Mak W.W., Cooper G.J.S. and Xu A., Posttranslational modifications on the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high-molecular-weight oligomeric complex, J Biol Chem. 2006.

 

Researcher : Lam KSL



Project Title:

Genetic and hormonal influences on phenotypic expression of apolipoprotein (a)

Investigator(s):

Lam KSL

Department:

Medicine

Source(s) of Funding:

Outstanding RGC Projects

Start Date:

11/1998

 

Abstract:

To enhance research level.

 

Project Title:

Clinical, genetic and functional studies of two novel fat-derived hormones

Investigator(s):

Lam KSL, Wat NMS, Xu A

Department:

Medicine

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

08/2003

Completion Date:

07/2005

 

Abstract:

To conduct a systematic analysis of the polymorphisms and mutations in the resistin and adiponectin genes in Southern Chinese and to investigate, in cross-sectional and prospective studies, their association with insulin resistance and related disorders including obesity, impaired glucose tolerance, type 2 diabetes, hypertension, dyslipidaemia and carotid atherosclerosis; to determine the relationship of serum resistin to indices of insulin resistance in population studies; to investigate whether circulating adiponectin levels and isoforms, and resistin levels are genetically determined, whether they are predictive of the development of diabetes and hypertension in a 5-year prospective study, and whether they are associated with the development of carotid atherosclerosis; to examine the relationship of circulating adiponectin and resistin to other causes of insulin resistance including age, growth hormone excess and presence of chronic systemic inflammation; to elucidate how the genetic mutations/polymorphisms lead to altered expression and/or functions of resistin and adiponectin using site-directed mutagenesis and functional studies. To investigate whether circulating adiponectin and resistin levels are genetically determined, whether they are predictive of the development of diabetes and hypertension in a 5-year prospective study, and whether they are associated with the development of carotid atherosclerosis.

 

Project Title:

Clinical, genetic and functional studies of two novel fat-derived hormones

Investigator(s):

Lam KSL, Wat NMS, Xu A

Department:

Medicine

Source(s) of Funding:

Merit Award for RGC CERG Funded Projects

Start Date:

08/2003

 

Abstract:

N/A

 

Project Title:

Autocrine functions of adipokines

Investigator(s):

Lam KSL, Xu J, Xu A

Department:

Medicine

Source(s) of Funding:

Small Project Funding

Start Date:

11/2003

Completion Date:

10/2005

 

Abstract:

To establish a system to stably and efficiently suppress the expression of resistin, adiponectin and adipocyspin in mouse adipocytes using RNA interference; to investigate the autocrine function of these adipolines on adipogenesis, lipolysis, lipogenesis and insulin sensitivity in the gene-knock down cell models.

 

Project Title:

Adiponectin as a novel diagnostic marker and therapeutic target for the treatment of diabetes, steatohepatitis and other metabolic disorders

Investigator(s):

Lam KSL, Xu A, Shen J, Chao Y.S.

Department:

Medicine

Source(s) of Funding:

Innovation and Technology Support Programme

Start Date:

11/2003

Completion Date:

04/2006

 

Abstract:

To develop, standardize and evaluate an ultra sensitive and rapid adiponectin assay kit for prognostic assessment of these metabolic disorders in obese populations, for selecting the most effective therapeutic drugs for patients with these health problems; and for monitoring their response to tailored treatment; to use our recently established high-throughout adiponectin promoter assay system to screen for novel drugs from tradtional Chinese medicine and other chemical libraries that can enhance the production of the subject's endogenous adiponectin, which can be used for the treatment of the Metabolic Syndrome (type 2 diabetes, dyslipidemia, fatty liver and atherosclerosis), alcoholic liver injury, and metabolic disorders associated with treatment for HIV infections.

 

Project Title:

Linking the metabolic syndrome with progressive atherosclerosis: role of fat-derived hormones

Investigator(s):

Lam KSL, Chau MT, Wat NMS, Xu A

Department:

Medicine

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

09/2004

 

Abstract:

To determine whether serum levels of adiponectin are predictive of progressive atherosclerosis in man in a 5-year prospective study; to establish a sensitive ELISA method for accurate quantification of human PGAR and investigate the relationship of serum PGAR levels with obesity, insulin resistance, glucose tolerance, blood pressure, lipid levels and progression in carotid atherosclerosis; to investigate the effects of adenovirus-mediated chronic administration of adiponectin or PGAR on glucose and lipid metabolism, and development of atherosclerosis in db/db mice, an animal model of the metabolic syndrome.

 

Project Title:

Adiponectin as a novel diagnostic marker and therapeutic target for the treatment of diabetes, steatohepatitis and other metabolic disorders

Investigator(s):

Lam KSL

Department:

Medicine

Source(s) of Funding:

Innovation and Technology Fund Internship Programme

Start Date:

11/2004

Completion Date:

10/2005

 

Abstract:

The main objectives of this project are: 1) To develop, standardize and evaluate an ultra sensitive and rapid adiponectin assay kit for projnostic assessment of these metabolic disorders in obese populations, for selecting the most effective therapeutic drugs for patients with these health problems; and for monitoring their response to tailored treatment; and 2) To use our recently established high-throughout adiponectin promoter assay system to screen for novel drugs from traditional Chinese medicine and other chemical libraries that can enhance the production of the subject's endogenous adiponectin, which can be used for the treatment of the Metabolic Syndrome (type 2 diabetes, dyslipidemia, fatty liver and atherosclerosis), alcoholic liver injury, and metabolic disorders associated with treatment for HIV infections.

 

Project Title:

Linking the metabolic syndrome with progressive atherosclerosis: role of fat-derived hormones

Investigator(s):

Lam KSL

Department:

Medicine

Source(s) of Funding:

Merit Award for RGC CERG Funded Projects

Start Date:

01/2005

 

Abstract:

N/A

 

Project Title:

Application for seed fund for the strategic theme on healthy ageing

Investigator(s):

Lam KSL, Che CM, Lee TMC, Lee WWM, McMillan AS, Chen SF

Department:

Medicine

Source(s) of Funding:

Seed Funding for Strategic Research Theme

Start Date:

05/2005

 

Abstract:

To integrate the existing strengths in aging related research within HKU through the identification of important themes of common interest; to provide core platforms for interdisciplinary research on aging diseases; to develop novel therapeutic approaches for the promotion of healthy aging.

 

Project Title:

Macrophage-adipocyte cross-talk in the initiation of obesity-related insulin resistance and type 2 diabetes: role of adiponectin

Investigator(s):

Lam KSL

Department:

Medicine

Source(s) of Funding:

Merit Award for RGC CERG Funded Projects

Start Date:

09/2005

 

Abstract:

N/A

 

Project Title:

Macrophage-adipocyte cross-talk in the initiation of obesity-related insulin resistance and type 2 diabetes: role of adiponectin

Investigator(s):

Lam KSL, Xu A, Lao TTH

Department:

Medicine

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

09/2005

 

Abstract:

To determine the time course and magnitude of macrophage infiltration in fat tissue, changes in the blood and fat tissue levels of adiponectin, pro-inflammatory cytokines and other adipocyte-derived hormones, in relation to changes in glucose tolerance and insulin sensitivity, in db/db mice; to investigate, in db/db mice, an animal model of genetically predisposed obesity and type 2 diabetes, whether the therapeutic use of adiponectin can prevent or reduce the above pro-inflammatory changes, insulin resistance and/or type 2 diabetes; to confirm whether the inflammatory and hormonal changes in the blood and fat tissue of obese mice, and their correlation with glucose tolerance and insulin sensitivity, are also observed in overweight or obese Chinese subjects; to determine, in type 2 diabetic patients, the contribution of changes in circulating adiponectin to the anti-inflammatory and insulin-sensitizing actions of rosiglitazone, a PPAR-γ agonist which can increase adiponectin expression

 

Project Title:

Human ANGPTL4 Gene: Molecular Scanning and Evaluation of Association with Insulin Resistance and Type 2 diabetes in Chinese

Investigator(s):

Lam KSL, Xu J, Xu A

Department:

Medicine

Source(s) of Funding:

Small Project Funding

Start Date:

10/2005

 

Abstract:

The angiopoietin like protein-4 (ANGPTL4) is a hormone, predominantly derived from fat cells, which has been recently shown by our group to decrease blood glucose and hepatic insulin resistance in rodents. The purpose of this project is to determine whether the ANGPTL4 gene plays a significant role in the genetic susceptibility to diabetes and other insulin resistance related traits in humans, using blood and DNA samples collected from on-going cross-sectional and prospective studies. Objectives 1. To systematically search for polymorphisms in the human ANGPTL4 gene in southern Chinese 2. To perform case control association studies of ANGPTL4 polymorphisms and haplotypes with the risk of T2DM, obesity, insulin resistance, and hyperlipidemia 3. To investigate the role of ANGPTL4 polymorphisms and haplotypes in predicting the development of diabetes in a 10- year prospective follow-up study of 600 non-diabetic subjects 4. To determine the role of genetic polymorphisms in regulating circulating ANGPTL4 levels

 

List of Research Outputs

 

Chen B., Lam K.S.L., Wang Y., Wu D., Lam C.W., Shen J., Wong L.C., Hoo R.L.C., Zhang J. and Xu A., Hypoxia dysregulates the production of adiponectin and plasminogen activator inhibitor-1 independent of reactive oxygen species in adipocytes, Biochem Biophys Res Commun. 2006, 341: 549-56.

 

Cheng K.Y., Lam K.S.L. and Xu A., Receptor and postreceptor signalling pathways that mediate adiponectin-induced Akt activation in endothelial cells, 11th Medical Research Conference, HKU, Jan 2006.

 

Cheung B.M.Y., Leung R.Y.H., Man Y.B., Ong K.L., Wong L.Y.F., Lau C.P. and Lam K.S.L., Association of hypertension with single nucleotide polymorphisms in the quantitative trait locus for abdominal obesity-metabolic syndrome on chromosome 17, J Hum Hyperten. 2006.

 

Cheung B.M.Y., Ong K.L., Man Y.B., Lam K.S.L. and Lau C.P., Prevalence, Awareness, Treatment, and Control of Hypertension: United States National Health and Nutrition Examination Survey 2001-2, Journal of Clinical Hypertension. United States, Elsevier, 2006, 8: 93-98.

 

Cheung B.M.Y., Lo J.L., Fong H.Y., Chan M.Y., Wong S.H., Wong C.M., Lam K.S.L., Lau C.P. and Karlberg J.P.E., Randomised controlled trial of qigong in the treatment of mild essential hypertension, J Hum Hypertens. 2005, 19: 697-704.

 

Fong D.Y.T. and Lam K.S.L., Use of multiple imputation on linear mixed model and generalized estimating equations for longitudinal data analysis, The XVII IEA World Congress of Epidemiology. Bangkok, Thailand, 2005.

 

Ku C.F., Lo C.Y., Chan W.F., Kung A.W.C. and Lam K.S.L., Total thyroidectomy replaces subtotal thyroidectomy as the preferred surgical treatment for Graves' disease, ANZ J Surg. 2005, 75(7):: 528-31.

 

Lam A.K.Y., Lo C.Y. and Lam K.S.L., Papillary carcinoma of thyroid: A 30-yr clinicopathological review of the histological variants, In: Tischeler Arthur S, Endocrine Pathology. 2005, 16(4): 323-330.

 

Lam J.C.M., Lam B., Lam C.L., Fong D.Y.T., Wang J., Tse H.F., Lam K.S.L. and Ip M.S.M., Obstructive sleep apnoea and the metabolic syndrome in community based Chinese adults in Hong Kong, Respiratory Medicine. 2006, 100: 980-987.

 

Lam J.C.M., Lam B., Lam C.L.K., Fong D.Y.T., Wang J.K.L., Tse H.F., Lam K.S.L. and Ip M.S.M., Obstructive sleep apnoea and the metabolic syndrome in community-based, Chinese Adults in Hong Kong Resp Med . 2006, 100: 980-987.

 

Lam K.S.L. and Xu A., Adiponectin: Protection Of The Endothelium. , Curr Diab Rep. 2005, 4: 254-9.

 

Lam K.S.L., Current Diabetes Management in Asia: New Concepts, New Tools, Asean Federation of Endocrine Societies (AFES) Congress 2005, Manila, Philippines. 2005.

 

Lam K.S.L., Discovery of novel metabolites from marine actinomycetes ( Review), Curr Opin Microbiol. 2006, 9: 245-51.

 

Lam K.S.L., Pleuripotency of Adiponectin – insights from animal studies, 7th Molecular Diabetology in Asia, Hong Kong. 2005.

 

Lam K.S.L., Role of Incretins in Glucose Homeostasis and β-cell Function, Asean Federation of Endocrine Societies (AFES) Congress 2005, Manila, Philippines. 2005.

 

Man K., Zhao Y., Xu A., Lo C.M., Lam K.S.L., Ng T.P., Ho J.W.Y., Sun K.W., Lee K.W., Li X. and Fan S.T., Fat-derived hormone adiponectin combined with FTY720 significantly improves small-for-size fatty liver graft survival, American Journal of Transplantation. 2006, 6(3): 467-476.

 

Pang R.W.C., Tam S., Janus E.D., Siu S.T.S., Ma O.C.K., Lam T.H. and Lam K.S.L., Plasma lipid, lipoprotein and apolipoprotein levels in a random population sample of 2875 Hong Kong Chinese adults and their implications (NCEP ATP-III, 2001 guidelines) on cardiovascular risk assessment, Atherosclerosis. 2006, 184: 438-445.

 

Thomas G.N., McGhee S.M., Schooling C.M., Ho D.S.Y., Lam K.S.L., Janus E.D. and Lam T.H., Determinants of normoglycemia and contribution to cardiovascular risk factors in a Chinese population: The Hong Kong cardiovascular risk factor study, Journal of Endocrinological Investigation. 2006, 29: 528-535.

 

Thomas G.N., McGhee S.M., Schooling C.M., Ho D.S.Y., Lam K.S.L., Janus E.D. and Lam T.H., Impact of sex-specific body composition on cardiovascular risk factors: The Hong Kong cardiovascular risk factor study, Metabolism, Clinical and Experimental . 2006, 55: 563-569.

 

Thomas G.N., Schooling C.M., McGhee S.M., Ho D.S.Y., Cheung B.M.Y., Wat N.M.S., Janus E.D., Lam K.S.L. and Lam T.H., Smoking effect modification on all-cause and vascular mortality associated with the metabolic syndrome: The Hong Kong cardiovascular risk factor study (abstract), 4th Annual Conference of the International Society for the Prevention of Tobacco Induced Disease, 30 September - 2 October 2005, Athens, Greece. Athens, Greece, Int'l Society for the Prevention of Tobacco Induced Disease, 2005.

 

Tso A.W.K., Wat N.M.S., Xu A., Tam S., Fong H.Y., Janus E.D., Tan K.C.B. and Lam K.S.L., Adiponectin/C-reactive protein ratio is an independent surrogate marker predictive of the development of metabolic risks and the metabolic syndrome over 5 years in Chinese, The 6th International Diabetes Federation Western Pacific Region Congress, Bangkok, Oct 2005.

 

Wang Y., Lam K.S.L., Leung T.Y. and Xu A., Overexpression of Angiopoietin-like Protein 4 Alters the Protein Expression Profiles of the Liver Tissue in DB/DB Diabetic Mice, Molecular & Cellular Proteomics. HUPO 4th Annual Congress, 2005, 4 (S1): S200.

 

Wang Y., Lam K.S.L., Lam M. and Xu A., Overexpression of Angiopoietin-like protein 4 alters the protein expression profiles of the liver tissue in db/db diabetic mice, HUPO 4th Annual World Congress. 2005, 4: S200.

 

Wang Y., Lam K.S.L., Chan L., Chan K.W., Lam J.B.B., Lam C.W., Hoo R.L.C., Mak W.W., Cooper G.J. and Xu A., Post-translational modifications of the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high molecular weight oligomeric complex, J Biol Chem. 2006, 281: 16391-400.

 

Wang Y., Lam K.S.L., Chan L., Chan K.W., Lam J.B.B., Lam C.W., Hoo R.L.C., Mak W.W., Cooper G.J.S. and Xu A., Posttranslational modifications on the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high-molecular-weight oligomeric complex, J Biol Chem. 2006.

 

Wang Y., Lam K.S.L., Cooper G.J. and Xu A., Structural and functional relationship of Adiponectin as an anti-aging hormone, Frontiers in Biomedical Research. 2005, 62.

 

Xu A., Wang Y., Xu J., Stejskal D., Tam S., Zhang J., Wat N.M.S., Wong W.K. and Lam K.S.L., Adipocyte fatty acid-binding protein is a plasma biomarker closely associated with obesity and metabolic syndrome, Clinical Chemistry. 2006, 52: 405-413.

 

Xu R., Ma H., Li H., Sham M.H., Li E.T.S., Tam P.K.H. and Lam K.S.L., Oral viral vector gene delivery, In: Redberry GW (ed). Trends in Gene Therapy Research. New York, U.S.A., Nova Sciecen Publishers, Inc., 2005, 191-221.

 

Researcher : Lam L



List of Research Outputs

 

Kwong Y.L., Lau W.C.S., Ho S.L., Epstein R., Young R.T.T., Chan H.H.L., Tse H.F., Lam L., Chen W.H., Lee K.L.F., Ip M.S.M., Tsang K.W.T., Lam B., Tang S.C.W., Chan R.H.W., Lee S.W.L., Tan K.C.B., Yeung C.K., Chan D.T.M., Wong R.W.S., Choy C.B.Y., Wong B.C.Y., Li F.K., Lo W.K., Lui S.L., Cheung R.T.F., Mak W., Ho J.C.M., Mok T.M.Y., Kung A.W.C., Cheung B.M.Y., Chow W.S., Yuen R.M.F. and Wat N.M.S., In: Lau CP, Kumana CR, Lai CL, Lai KN, Lam KSL, Lam WK, Problem-Based Medical Case Management. Hong Kong, Hong Kong University Press, 2005.

 

Yiu K.H., Siu C.W.D., Lee K.L.F., Lam L., Chan R.H.W., Lee S.W.L., Lau C.P. and Tse H.F., Adverse Clinical Outcomes in Left-sided Infective Endocarditis Complicated Intravenous drug addict, JACC . 2006, 47: 281A.

 

Yiu K.H., Siu C.W.D., Lee K.L.F., Lam L., Chan R.H.W., Lee S.W.L., Lau C.P. and Tse H.F., Temporal Trend of Infective Endocarditis in Chinese: A Population Based Study Over 10 Years Period, JACC. 2006, 984-24.

 

Researcher : Lam SK



Project Title:

Chemoprevention of gastric cancer by intervention with Helicobacter pylori and cyclooxygenase pathway

Investigator(s):

Lam SK, Wong BCY, Xu G.W.

Department:

Medicine

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

12/2001

 

Abstract:

To assess if the combination of treatment of Helicobacter pylori infection and use of specific cyclooxygenase-2 inhibitors in asymptomatic individuals can reduce the incidence of gastric cancer in a high risk area over a five to ten year period; to assess if the combination of treatment of Helicobacter pylori infection and use of specific cyclooxygenase-2 inhibitors will lead to progression or regression of various precancerous gastric conditions including gastric atrophy, intestinal metaplasia and dysplasia over a three year period; to assess the long term sequelae of Helicobacter pylori eradication and use of specific cyclooxygenase-2 inhibitors histologically, including changes in cell proliferation, apoptosis and oncogene expressions.

 

Project Title:

Biotech Company in the Faculty of Medicine, The University of Hong Kong

Investigator(s):

Lam SK

Department:

Medicine

Source(s) of Funding:

The University of Hong Kong Foundation Seed Grant

Start Date:

07/2003

 

Abstract:

To enable the Faculty of Medicine of The University of Hong Kong to establish itself as the regional centre of excellence in the provision of complete solutions to industry from laboratory research services to clinical trials, setting standards and quality benchmarks comparable to the best international practices for other similar centres in the region to follow.

 

Project Title:

Treatment of gastrointestinal cancer by targeting survivin using adeno-associated virus gene delivery system

Investigator(s):

Lam SK, Wong BCY, Lin MC

Department:

Medical Faculty

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

09/2004

 

Abstract:

To elucidate the molecular mechanisms of survivin in tumor angiogenesis, to will investigater the effect of overexpression of survivin on the migration and capillary tuber-like networks of endothelial cells, expression of angiogenic factors in gastrointestinal cancer cells and angiogenesis in Chorioallantoic membrane angiogenesis (CAM) model and nude mice xenograft; to establish a novel gene therapy for gastrointestinal cancer by targeting survivin gene with adeno-associated virus vector. We will further study the therapeutic effect of rAAV-mediated survivin mutant on gastrointestinal cancer in vivo and evaluate long-term effect and safety of the rAAV virus.

 

Project Title:

The prevalence of Obstructive Sleep Apnea Syndrome (OSAS) in patients with gastro-oesophageal reflux disease (GERD) and the effects of proton pump inhibitor therapy on OSAS and quality of sleep in Hong Kong Chinese

Investigator(s):

Lam SK, Wong RWM, Ip MSM

Department:

Medical Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

 

Abstract:

To study the prevalence of Obstructive Sleep Apnea Syndrome (OSAS) in Chinese patients with gastro-oesophageal reflux disease (GERD) and the effects of proton pump inhibitor therapy on OSAS and quality of sleep in patients with GERD.

 

Project Title:

Treatment of gastrointestinal cancer by targeting survivin using adeno-associated virus gene delivery system

Investigator(s):

Lam SK

Department:

Medical Faculty

Source(s) of Funding:

Merit Award for RGC CERG Funded Projects

Start Date:

01/2005

 

Abstract:

N/A

 

Project Title:

Characterization of the role of FHL2 in the induction of apoptosis and therapy of GI cancers

Investigator(s):

Lam SK

Department:

Medical Faculty

Source(s) of Funding:

Incentive Award for RGC CERG Fundable But Not Funded Projects

Start Date:

07/2005

Completion Date:

06/2006

 

Abstract:

N/A

 

List of Research Outputs

 

Chan O.O., Hui W.M., Chan C.K., Lai K.C., Hu H.C., Yuen R.M.F., Wong R.W.M., Lau G., Hui C.K., Lam S.K. and Wong B.C.Y., Colonoscopy Demand and Practice in a Regional Hospital over 9 Years in Hong Kong: Resource Implication for Cancer Screening, Gastroenterology. 2006, 130 (4 Suppl 2): A-618.

 

Chan O.O., Hui W.M., Chan C.K., Lai K.C., Hu H.C., Yuen R.M.F., Wong R.W.M., Lau G., Hui C.K., Lam S.K. and Wong B.C.Y., Colonoscopy demand and practice in a regional hospital over 9 years in Hong Kong: Resource implication for cancer screening, Digestion. 2006, 73(2-3): 84-88.

 

Chan O.O., Cheng C., Hui W.M., Hu H.C., Wong Y.H., Lam K.F., Wong R.W.M., Lai K.C., Lam S.K. and Wong B.C.Y., Differing coping mechanisms, stress level and anorectal physiology in patients with functional constipation, World Journal of Gastroenterology. The WJG Press and Elsevier Inc., 2005, 11(34): 5362-5366.

 

Chan O.O., Chu K.M., Lam S.K., Cheung K.L., Law S.Y.K., Kwok K.F., Wong R.W.M., Yuen R.M.F. and Wong B.C.Y., Early prediction of tumor recurrence after curative resection of gastric carcinoma by measuring soluble E-cadherin, Cancer. 2005, 104(4): 740-6.

 

Chan O.O., Peng J., Lam S.K., Lai K.C., Yuen R.M.F., Cheung K.L., Kwong Y.L., Rashid A., Chan C.K. and Wong B.C.Y., Eradication of Helicobacter pylori Infection Reverses E-cadherin Promoter Hypermethylation, Gut. 2006, 55: 463-468.

 

Chan O.O., Hui W.M., Hu H.C., Leung G., Chan C.K., Yuen R.M.F., Lam S.K. and Wong B.C.Y., Familial Aggregation in Constipated Subjects in a Tertiary Referral Center, Gastroenterology. 2006, 130 (4 Suppl 2): A-159.

 

Chan O.O., Chu K.M., Leung S.Y., Huang C., Sun Y.W., Ko S., Yuen R.M.F., Xia H.H.X., Cho C.H., Hui W.M., Lam S.K., Rashid A. and Wong B.C.Y., Helicobacter pylori infection, interleukin 1 beta polymorphism and predisposition to gastric cancer through the CpG island methylation pathway, Presented at 11th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong, 14 January 2006.

 

Chan O.O., Jim M.H., Lam K.F., Siu D.C.W., Tong S.M., Ng F.H., Hui W.M., Chan C.K., Lai K.C., Hu H.C., Yuen R.M.F., Lau Y.K., Lee S.W.L., Lam S.K. and Wong B.C.Y., Patients with Coronary Artery Disease are at High Risk for Developing Colorectal Cancer and Adenoma: An Interim Analysis of a Prospective Study, Gastroenterology. 2006, 130 (4 Supp 2): A-36.

 

Chan O.O., Hui W.M., Lam K.F., Leung G., Hu H.C., Chan C.K., Yuen R.M.F., Lam S.K. and Wong B.C.Y., The Clinical Characteristics of Patients with Idiopathic Constipation with a Positive Family History, Gastroenterology. 2006, 130 (4 Suppl 2): A-158.

 

Chan O.O., Chu K.M., Sun Y.W., Cheung H.K.L., Lam S.K., Yuen R.M.F., Hui W.M. and Wong B.C.Y., The association between interleukin 1 beta polymorphism and hypermethylation at tumor suppressor genes in gastric cancer. , Gastroenterology. 2005, 128 (Suppl 2): 1399-400.

 

Chan O.O., Lam K.F., Hui W.M., Hu W.H., Li J., Lai K.C., Chan C.K., Yuen R.M.F., Lam S.K. and Wong B.C.Y., Validated questionnaire on diagnosis and symptom severity for functional constipation in the Chinese population, Alimentary Pharmacology and Therapeutics. Blackwell Publishing Ltd, 2005, 22: 483-488.

 

Chan O.O., Chu K.M., Leung S.Y., Huang C., Sun Y., Ko S., Yuen R.M.F., Xia H.H.X., Cho C.H., Hui W.M., Lam S.K., Rashid A. and Wong B.C.Y., Helicobacter pylori Infection, Interleukin 1 Beta Polymorphism and Predisposition to Gastric Cancer Through the Cpg Island Methylation, Gastroenterology. 2006, 130 (4 Suppl 2): A-717.

 

Gu Q., Xia H.H.X., Wang J., Wong R.W.M., Chan O.O., Lai K.C., Chan C.K., Yuen R.M.F., Fung F.M.Y., Wong K.W., Lam S.K. and Wong B.C.Y., Update on clarithromycin resistance in Helicobacter pylori in Hong Kong and its effect on clarithromycin-based triple therapy., Digestion. 2006, 72(2-3): 101-106.

 

He H., Xia H.H.X., Wang J., Gu Q., Lin M.C., Zou B., Lam S.K., Chan O.O., Yuen R.M.F., Kung H.F. and Wong B.C.Y., Inhibition of human telomerase reverse transcriptase by nonsteroidal antiinflammatory drugs in colon carcinoma, Cancer. 2006, 106(6): 1243-9.

 

Lai K.C., Chu K.M., Hui W.M., Wong B.C.Y., Hu H.C., Wong W.M.R., Chan O.O.A., Wong J. and Lam S.K., Celecoxib compared with lansoprazole and naprosyn to prevent gastrointestinal ulcer complications, American Journal of Medicine. 2005, 118: 1271-1278.

 

Lam S.K., Cheng Si Yuan Memorial Lecture, Shanghai-HK Int’l Liver Congress, Shanghai (March 25-28, 2006). 2006.

 

Lam S.K., Cox1, Cox2 and H. pylori-induced Gastric Inflammation, 4th International Symposium on Cell/Tissue Injury and Cytoprotection /Organoprotection (Focus on GI Tract), Long Beach (May 17-19, 2006). 2006.

 

Lam S.K., Eradication of Helicobacter pylori and Gastric Cancer: Experience in Fujian Province of China, Chinese Journal of Digestive Diseases. 2005, 6: 116-118.

 

Lam S.K., GERD and Barrett's Esophagus, 5th Shanghai International Conference of Gastroenterology, Shanghai (July 7-9, 2005). 2005.

 

Lam S.K., H. pylori and Upper Gastrointestinal Symptoms, World Congress of Gastroenterology, Montreal (September 12-14, 2005). 2005.

 

Lam S.K., Jiang Shao-Ji Lecture: Gastroesophageal Reflux Disease in the Asian Pacific-The Birth of a New Disease, 5th Shanghai International Conference of Gastroenterology, Shanghai (July 7-9, 2005). 2005.

 

Lam S.K., Nanogastroenterology: the Way to Reinvent Ourselves, 3rd Beijing International Digestive Disease Forum, Beijing (May 27-29, 2006). 2006.

 

Lam S.K., Nanogastroenterology: the Way to Reinvent Ourselves, Asian Pacific Digestive Week, Seoul (September 26-28, 2005). 2005.

 

Lam S.K., Potential Biomarkers in New Drug Development, World Congress of Gastroenterology, Montreal (September 12-14, 2005). 2005.

 

Lam S.K., Stem Cells and Tissue Regeneration, 4th International Symposium on Cell/Tissue Injury and Cytoprotection/Organoprotection (Focus on GI Tract), Long Beach (May 17-19, 2006). 2006.

 

Lam S.K., Symposium on IBS, 5th Shanghai International Conference of Gastroenterology, Shanghai (July 7-9, 2005). 2005.

 

Li G., Xia H.H.X., Chen M., Gu Q., Wang J., Peng J., Chan O.O., Cho C.H., So H.L., Lam S.K., Hu P.J., Liang Y.J., Lin H., Berg D.E., Feng Z.H., Langenback R. and Wong B.C.Y., Effects of Cyclooxygenase-1 and -2 Gene Disruption on Helicobacter pylori-Induced Inflammation, Journal of Infectious Diseases. 2006, 193(7): 1037-1046.

 

Tang L.P., Cho C.H., Hui W.M., Huang F.Y., Lai C.L., Xia H.H.X., Lam S.K., Rashid A., Wong B.C.Y. and Chan O.O., A negative correlation between IL-6 and DNA methylation in patients with gastric cancer, Supplement to Gastroenterology - Digestive Disease Week and the 107th Annual Meeting of the American Gastroenterological Association Institute, May 20-25, 2006, Los Angeles, CA. 2006, 130:4 Suppl 2: A-717.

 

Wang W., Huang J., Zheng G., Xia H.H.X., Wong R.W.M., Lam S.K. and Wong B.C.Y., Head-to-Head Comparison of H2-Receptor Antagonists and Proton Pump Inhibitors in the Treatment of Erosive Esophagitis: A Meta-Analysis, World Journal of Gastroenterology. 2005, 11(26): 4067-4077.

 

Wong B.C.Y., Chan O.O., Wong R.W.M., Hui W.M., Kung H. and Lam S.K., Attitudes and knowledge of colorectal cancer and screening in Hong Kong – A population-based study, Journal of Gastroenterology and Hepatology. 2006, 21(1 Pt 1): 41-46.

 

Xia H.H.X., Wong R.W.M., Chan O.O., Lam S.K., Lai K.C., Chan C.K., Cheung K.L., Fung F.M.Y., Wong K.W. and Wong B.C.Y., Natural acquisition of Helicobacter pylori in adult dyspeptic patients with or without previous infection – a 7-year follow-up study. Australian Gastroenterology Week 2005, 19 October 2005, Australia. , Journal of Gastroenterology and Hepatology. 2005, 20: Supp A112.

 

Zou B., Lin M.C., Lam S.K., Tu S., Zeng H., Yang Y., Wang J., He H., Jiang S.H., Kung H. and Wong B.C.Y., Distinguished Poster Award, "Hypermethylation status around exon 1 of XIAP-Associated Factor 1(XAF1) in human gastric and colon cancer cell line.", Asian Pacific Digestive Week, Sept. 25-28, Seoul, Korea.. 2005.

 

Zou B., Lin M.C., Lam S.K., Tu S., Zeng H., Yang Y., Wang J., He H., Jiang S.H., Kung H. and Wong B.C.Y., Hypermethylation status around exon 1 of XIAP-Associated Factor 1(XAF1) in human gastric and colon cancer cell line. Asian Pacific Digestive Week, Sept. 25-28, 2005, Seoul, Korea. , Journal of Gastroenterology and Hepatology. 2005, 20: Supp A370.

 

Researcher : Lam TP



Project Title:

Are mental health problems common among medical interns? - the sources of their distress and the support they need

Investigator(s):

Lam TP, Wong JGWS, Ip MSM

Department:

Med - Family Medicine Unit

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

Completion Date:

10/2005

 

Abstract:

To examine if mental health problems are common among medical interns, as well as the sources of their distress and the kind of support they need in Hong Kong.

 

Project Title:

Use of antibiotics by primary care doctors in Hong Kong

Investigator(s):

Lam TP, Ho PL, Lam KF, Choi

Department:

Med - Family Medicine Unit

Source(s) of Funding:

Small Project Funding

Start Date:

11/2005

Completion Date:

11/2006

 

Abstract:

Overuse of antibiotics is a worldwide phenomenon (1, 2) and it contributes to the emergence of antimicrobial resistance (3, 4, 5). Unnecessary use of antibiotics also leads to an increased risk of side effects (6), high costs (7) and medicalising effects (8). In the Fifty-eighth World Health Assembly held in May 2005, it was resolved and agreed by more than 60 countries (including Hong Kong and China) that the containment of antimicrobial resistance is one of the internationally agreed health-related goals but the strategy for it has not been widely implemented. It urges Member States (a) to enhance rational use of antimicrobial agents, including through development and enforcement of national standard practice guidelines for common infections, in public and private health sectors, (b) to monitor regularly the use of antimicrobial agents and the level of antimicrobial resistance in all relevant sectors, and (c) to share actively knowledge andexperience on best practices in promoting the rational use of antimicrobial agents. Primary care doctors prescribe most of all antibiotics and many of these are for infections of the respiratory tract (9) despite research studies demonstrating little or no clinical benefits (10-17). Surveys done by Lam & Lam revealed that antibiotics are frequently used in patients with respiratory tract infections in Hong Kong (18) and many doctors also acknowledged that they might be prescribing antibiotics too often for upper respiratory tract infections (URTI) (19). There are many possible reasons why primary care doctors in Hong Kong are prescribing antibiotics for URTI, for example, their misconceptions about the significance of fever, discoloured sputum or nasal discharge, exudates and lymphadenopathy (18), as well as patients' expectations (19). These findings were based on the primary care doctors' report of their clinical behaviours. They may therefore under estimate or even over estimate their use of antibiotics in these previous studies. There is otherwise no current information available on the actual usage of antibiotics by primary care doctors in Hong Kong. The proposed study represents a step forward in the understanding of the use of antibiotics by primary care doctors in Hong Kong. It aims to examine the primary care doctors' clinical behaviour in the use of antibiotics by detailing the type of antibiotics they use, including the dosage and duration, and the illnesses that they use the antibiotics. Similar study provided useful information to help reduce antibiotics use in Scadinavia (20). Objectives of the proposed study: 1. To document the level of use of antibiotics by primary care doctors in Hong Kong, including the types of antibiotics, dosage and duration. 2. To examine the primary care doctors' use of antibitocs and its relation to common infections in the community. 3. To examine the relationship between patients' expectation of antibiotics and the prescription of antibiotics by primary care doctors. 4. To identify the characteristics of primary care doctors e.g. age, gender, vocational training in general practice/family medicine and the use of antibiotics in the community. Hypotheses It is hypothesized that: 1. Antibiotics are too frequently used for common infections in primary care setting in Hong Kong. 2. Patients' expectation of antibiotics are associated with higher level of use of antibiotics by primary care doctors. 3. There is a close association between the level of use of antibiotics and certain characteristics of primary care doctors e.g. age, gender and vocational training experience. 1. Arroll B, Goodyear-Smith F. General practitioner management of upper respiratory tract infections: when are antibiotics prescribed? New Zealand Medical Journal 2000;113(1122):493-496. 2. Wang EE, Einarson TR, Kellner JD, Conly JM. Antibiotics prescribing for Canadian preschool children: evidence of overprescribing for viral respiratory infections. Clinical Infectious Disease 1999;29(1):155-160. 3. Schwartz B, Bell DM, Hughes JM, et al. Preventing the emergence of antimicrobial resistance. JAMA 1997;278:944-945. 4. Belongia EA, Schwartz B. Strategies for promoting judicious use of antibiotics by doctors and patients. BMJ 1998;317:668-671. 5. Seppala H, Klaukka T, Vuopio-Varkula J, Muotiala A, Helenius H, Lager K, et al. The effect of changes in the consumption of macrolide antibiotics on erythromycin resistance in group A streptococci in Finland. N Eng J Med 1997;337:441-6. 6. Arroll B, Kenealy T. Antibiotics for the common cold. Cochrane Database Syst Rev 2000;(2):CD000247. 7. Mainous III G, Hueston WJ. The cost of antibiotics in treating upper respiratory tract infections in a Medicaid population. Arch Fam Med 1999;7:45-9. 8. Little P, Gould C, Williamsen I, Warner G, Gantly M, Kinmonth AL. Reattendance and complications in a randomised trial of prescribing strategies for sore throat: the medicalising effect of prescribing antibiotics. BMJ 1997;315:350-2. 9. De Melker RA, Kuyvenhoven MM. Management of upper respiratory tract infections in Dutch family practice. J Fam Pract. 1994;38:353-7. 10. Little P, Williamson I, Warner G, et al. Open randomised trial of prescribing strategies in managing sore thoat. BMJ 1997;314:722-727. 11. Orr PH, Scherer K, MacDonald A, et al. Randomized placebo-controlled trials of antibiotics for acute bronchitis: a critical review of the Literature. J Fam Pract. 1993;36:507-512. 12. Gonzales R, Sande M. What will it take to stop physicians from prescribing antibiotics in acute bronchitis? Lancet 1995;345:665-666. 13. Verjeij TJM, Hermans J, Mulder JD. Effects of doxycycline in patients with acute cough and purulent sputum: a double-blind, placebo-controlled trial. Br J Gen Pract 1994;44:400-404. 14. Dunlay J, Reinhardt R, Roy LD. A placebo-controlled, double-blind trial of erythromycin in adults with acute bronchitis. J Fam Pract 1987;25:137-141. 15. King DE, Williams WC, Bishop L, et al. Effectiveness of erythromycin in the treatment of acute bronchitis. J Fam Pract 1996;42:601-605. 16. Heikkinen T, Ruuskanen O, Ziegler T, et al. Short-term use of amoxicillin-clavulanate during upper respiratory tract infection for prevention of acute otitis media. J Paediatr 1995;126:313-316. 17. Kaiser L, Lew D, Hirschel B, et al. Effects of antibiotic treatment in the subset of common-cold patients who have bacteria in nasopharyngeal secretions. Lancet 1996;347:1507-1510. 18. Lam TP, Lam KF. Why do family doctors prescribe antibiotics for upper respiratory tract infection? International Journal of Clinical Practice 2003:57(3):167-169 19. Lam TP, Lam KF. What are the non-biomedical reasons which make family doctors over-prescribe antibiotics for upper respiratory tract infection in a mixed private/public Asian setting? Journal of Clinical Pharmacy and Therapeutics. 2003;28:197-201. 20. Mikstra Programme - antimicrobial treatment strategies (Accessed in June 2005 http://www.stakes.fi/mikstra/e/)

 

List of Research Outputs

 

Chi I., Chou K.L., Kwan C.W., Lam K.F. and Lam T.P., Use of the Minimum Data Set - Home Care: A cluster randomized controlled trial among the Chinese older adults, Aging & Mental Health. Taylor & Francis, 2006, 10(1): 33-39.

 

Lam T.P., Are you looking after patients with low literacy level?, Hong Kong Practitioner. 2005, 27: 401-402.

 

Lam T.P., Co-Editor of Asia Pacific Family Medicine - the Official Journal of Wonca Asia Pacific. 2006.

 

Lam T.P., Factors affecting primary care doctors' decision to undertake postgraduate diploma studies., 11th Medical Research Conference, The University of Hong Kong. 2006.

 

Lam T.P., How to get started with a research project in primary care setting., Hong Kong Community Psychological Medicine Association. Hong Kong, 2006.

 

Lam T.P., Preventive Geriatrics, In: Kong TK (ed.), The Geriatric Curriculum. The Hong Kong Geriatric Society, 2005, Chapter 5.

 

Lam T.P., The origin of Problem Based Learning. (Letter), Medical Teacher. 2005, 27: 473.

 

Lam T.P., Thesis entitled: "A study of curriculum reform in an Asian medical school and the implications for medical education.", Doctor of Medicine, The University of Hong Kong. 2006.

 

Lam T.P., Lam K.F. and Tse E.Y.Y., Why do primary care doctors undertake postgraduate diploma studies in a mixed private/public Asian setting?, Postgraduate Medical Journal. BMJ Publ. Group Ltd & the Fellowship of Postgraduate Med., 2006, 82: 400-403.

 

McCall L., Klein B., Piterman L. and Lam T.P., Learning style preferences for Hong Kong general practitioners recruited in a distant-learning course., Hong Kong Practitioner. 2005, 27: 261-267.

 

McGhee S.M., Lam C.L.K., Lam T.P., Cheung B.M.Y., Schooling C.M. and McInnes G.T., An investigation into the current management of hypertension in Hong Kong: A two-phase study (Research dissemination report), Hong Kong Medical Journal. 2006, 12(2) Suppl 1: 24-27.

 

Researcher : Lam WK



List of Research Outputs

 

Chan M.M.W., Chan F.H.W., Cheung A.H.K., Dai D.L., Chu L.W., Lam W.K., Leung C.C., Kam K.M. and Tam C.M., Prevalence of tuberculous infection and active tuberculosis in old age homes in Hong Kong., Journal of the American Geriatrics Society. 2006, 54: 1334-40.

 

Chang K.C., Leung C.C., Tam C.M., Yu W.C., Hui D.S. and Lam W.K., Malignant mesothelioma in Hong Kong, Respiratory Medicine. 2006, 100: 75-82.

 

Ho J.C.M., Wong M.P. and Lam W.K., Lymphoepithelioma-like carcinoma of the lung, Respirology. 2006, 11: 539-545.

 

Ho J.C.M., Mak J.C.W., Ho S., Ip M.S.M., Tsang K.W.T., Lam W.K. and Chan M.M.W., Manganese superoxide dismutase and catalase genetic polymorphisms, activity levels and lung cancer risk in Chinese in Hong Kong. 11th World Conference on Lung Cancer , Lung Cancer. 2005, 49(Suppl 2): S191.

 

Ho J.C.M., Chua D.T.T., Cheng A.C., Sham J.S.T., Lam W.K. and Wong M.P., Predictive role of mutational status of epidermal growth factor receptor in clinical response to gefitinib in advanced non-small cell lung cancer, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong . 2006, Abstract Book: pp. 58.

 

Ho J.C.M., Tsang K.W.T. and Lam W.K., Respiratory Medicine-Long Cases , in CP Lau (eds), Problem-based medical case mangement. Hong Kong, Hong Kong University Press, 2006, 215-230.

 

Ho J.C.M., Tsang K.W.T. and Lam W.K., Respiratory Medicine-Short Cases , in CP Lau (eds), Problem-based medical case management. Hong Kong, Hong Kong University Press, 2006, 193-214.

 

Kwok R.P., Sun J.Z., Tipoe G.L., Leung Y.H., Yan C.P.K., Ooi C.G.C., Ho P.L., Mak J.C.W., Lam W.K. and Tsang K.W.T., Pseudomonas aeruginosa pyocyanin : discruption of ultrastructure of human respiratory mucosa in vitro, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong,. 2006, Abstract Book 087: pp. 55.

 

Kwok R.P., Sun J.Z., Tipoe G.L., Leung Y.H., Yan C.P.K., Ooi C.G.C., Ho P.L., Mak J.C.W., Lam W.K. and Tsang K.W.T., Pseudomonas aeruginosa pyocyanin : discruption of ultrastructure of human respiratory mucosa in vitro, Respirology. 2005, 10 (Suppl): A126 (#170).

 

Kwok R.P., Leung Y.H., Sun J.Z., Yan C.P.K., Ooi C.G.C., Ho P.L., Tipoe G.L., Lam W.K. and Tsang K.W.T., The effects of gelomyrtol ForteÒ on human ciliary beat frequency in bronchiectasis subjects in vitro, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2006, Abstract Book 086: pp.54.

 

Kwok R.P., Leung Y.H., Sun J.Z., Yan C.P.K., Ooi C.G.C., Ho P.L., Tipoe G.L., Lam W.K. and Tsang K.W.T., The effects of gelomyrtol forteÒ on human ciliary beat frequency in bronchiectasis subjects in vitro, Respirology. 2005, 10 (Suppl): A126 (#169).

 

Kwok R.P., Leung Y.H., Sun J.Z., Yan C.P.K., Ko K.W., Ooi C.G.C., Ho P.L., Tipoe G.L., Lam W.K. and Tsang K.W.T., The effects of myrtol standardized on human ciliary beat frequency in vitro, European Respiratory Medicine. 2005, 26 (Suppl 49): 100S (#714).

 

Lam B., Tam C.M., Lam S.Y., Wong M.P., Ooi C.G.C., Fung S.L., Lam D.C.L., Ip M.S.M. and Lam W.K., Detection of early lung cancer in high risk population: A prospective study. 11th World Conference on Lung Cancer, Lung Cancer. 2005, 49 (Suppl 2): S182 (P-257).

 

Lam B., Wong M.P., Fung S.L., Lam D.C.L., Wong P.C., Mok T.Y.W., Lam F.M., Ip M.S.M., Ooi C.G.C. and Lam W.K., The clinical value of autofluorescence bronchoscopy for the diagnosis of lung cancer, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2006, Abstract Book 094: pp. 58.

 

Lam C.L., Wong M.P., Girard L., Chung L.P., Chiu W.S., Suen W.S., Lam W.K. and Minna J.D., Gene expression profiling in lung adenocarcinomas reveals molecular signatures with respect to gender, smoking, histological grading and disease-free survival. 11th World Conference on Lung Cancer, Lung Cancer. 2005, 49 (Suppl 2): S133 (P-072).

 

Lam D.C.L., Wong M.P., Girard L., Chung L.P., Suen W.S., Lam W.K. and Minna J.D., Gene expression profiling in lung adenocarcinomas reveals molecular signatures correlating with clinical significance, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2006, Abstract Book 090: pp. 56.

 

Lam D.C.L., Girard L., Ramirez R.D., Lam W.K. and Minna J.D., Nicotine exposure in normal human bronchial epithelial cell lines leads to significant expression of specific nicotine acetylcholine receptor (nAChR) subunit genes, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong . 2006, Abstract Book 091: pp. 57.

 

Lam W.K., 10th Congress of the Asian Pacific Society of Respirology & 1st Joint Congress of the Asian Pacific Society of Respirology/American College of Chest Physicians, Guangzhou, China. 2005.

 

Lam W.K., Ambient air pollution and the lung, 10th Congress of the Asian Pacific Society of Respirology & Joint 1st Conference of the Asian Pacific Society of Respirology and American College of Chest Physicians, Guangzhou, China. 2005, Programme & Synpsosis Book: p. 55.

 

Lam W.K., Lung Cancer (in Chinese), Anti-Cancer Society. 2006, 10-page leaflet.

 

Lam W.K., Lung cancer in Asian women - the environment and genes, Respirology. 2005, 10: 408-417.

 

Lam W.K. and Tsang K.W.T., Severe acute respiratory syndrome : what lessons have been learnt? - an update, e-Bulletin of the Royal College of Physicians of Edinburgh. 2006.

 

Mak J.C.W., Leung C.M., Ho S.P., Law K.W., Ho A.S.S., Lam W.K., Ip M.S.M. and Chan M.M.W., Analysis of transforming growth factor-beta(1) gene polymorphisms in Hong Kong Chinese asthmatic patients, Journal of Allergy and Clinical Immunology. 2006, 117: 92-96.

 

Mak J.C.W., Leung C.M., Ho S.P., Law K.W., Tsang K.W.T., Lam W.K., Ip M.S.M. and Chan M.M.W., Best Poster - Genetic Susceptibility Of Transforming Growth Factor-beta1 Common Polymorphisms To Chinese Patients With Asthma, Hong Kong Allergy Convention 2005 . 2005.

 

Mak J.C.W., Ho S.P., Leung Y.H., Ho P.L., Ooi C.G.C., Tipoe G.L., Yan C.P.K., Ip M.S.M., Lam W.K. and Tsang K.W.T., Elevated levels of transforming growth factor-beta(1) in serum of patients with stable bronchiectasis, Respiratory Medicine. 2005, 99: 1223-1228.

 

Mak J.C.W., Leung C.M., Ho S.P., Law K.W., Tsang K.W.T., Lam W.K., Ip M.S.M. and Chan M.M.W., Genetic susceptibility of transforming growth factor-beta(1) common polymorphisms to Chinese patients with asthma, Hong Kong Allergy Convention, Hong Kong. 2005, Abstract AB25: p.54.

 

Mak J.C.W., Ho S.P., Leung C.M., Lam W.K., Ip M.S.M. and Chan M.M.W., Genetic susceptibility to chronic obstructive pulmonary disease (COPD) : Transforming growth factor-beta common polymorphisms and plasma levels, American Journal of Respiratory and Critical Care Medicine. 2006, 173(3): A624.

 

Mak J.C.W., Ho S.P., Leung C.M., Lam W.K., Ip M.S.M. and Chan M.M.W., Genetic susceptibility to chronic obstructive pulmonary disease (COPD) : transforming growth factor-beta(1) common polymorphisms and plasma levels, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong, January 2006. Abstract Book 089: pp.56.

 

Mak J.C.W., Hui W.S., Ho S.P., So W.H.L., Chan M.M.W., Cho C.H. and Lam W.K., Inducation of CINC-1 in the lung tissue from rats exposed to cigarette smoke, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2006, Abstract Book 088: pp. 55.

 

Mak J.C.W., Hui W.S., Ho S.P., So W.H., Chan M.M.W., Cho C.H. and Lam W.K., Induction of CINC-1 in the lung tissue from rats exposed to cigarette smoke, American Journal of Respiratory and Critical Care Medicine. 2006, 173(3): A634.

 

Mak J.C.W., Ho J.C.M., Ho S.P., Leung C.M., Law K.W., Lam W.K., Ip M.S.M. and Chan M.M.W., Polymorphisms in superoxide dismutase (SOD) and catalase genes - functional study in Chinese patients with asthma, Hong Kong Allergy Convention, Hong Kong. 2005, Abstract AB26: p.54.

 

Mak J.C.W., Hui W.S., Tipoe G.L., Lam W.K. and Tsang K.W.T., Regulation of cytokine- and phorbol ester-mediated interleukin (IL)-8 expression in the absence of presence of pyocyanin in human bronchial epithelial cell line: roles of protein kinase C and mitogen-activated protein kinases, European Respiratory Journal. 2005, 26 (Suppl 49): 99S (#709).

 

Mak J.C.W., Ho S.P., Wong M.P., Tsang K.W.T., Ip M.S.M., Lam W.K. and Chan M.M.W., Transforming growth factor (TGF)-b[sub]1[/sub] gene common polymorphisms and plasma TGF-b[sub]1[/sub] levels in patients with lung cancer, European Respiratory Journal. 2005, 26 (Suppl 49): 435S (#2797).

 

Ooi C.G.C., Ho J.C.M., Lam B., Lai A.Y.K., Tsang K.W.T. and Lam W.K., Relationship between MR intra-abdominal fat parameters and cardiovascular risk parameters in obstructive sleep apnoea, Respirology. 2005, 10 (Suppl): A176 (#366).

 

Pan N.Y., Hui W.S., Tipoe G.L., Lam W.K., Tsang K.W.T. and Mak J.C.W., Effects of glucocorticosteroids and antimicrobial drugs on inhibition of IL-1-beta and PDBu-induced IL-8 release in the presence of pyocyanin in bronchial epithelial cell line, European Respiratory Journal. 2005, 26(Suppl 49): 99s.

 

Tam I.Y.S., Chung L.P., Suen W.S., Wang E., Wong M.C.M., Ho K.K., Lam W.K., Chiu S.W., Girard L., Minna J.D., Gazdar A.F. and Wong M.P., Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features, Clinical Cancer Research. 2006, 12(5): 1647-53.

 

Tsang K.W.T., Eng P., Liam C.K., Shim Y.S. and Lam W.K., H5N1 influenza pandemic: contingency plans, Lancet (London, England : Online). 2005, 366(9485): 533-534.

 

Tsang K.W.T., Shim Y.S., Wong T.K., Liam C.K., Eng P., Lam W.K. and Seto W.H., Possible case scenarios and logistic issues in H5N1 pandemic, Respirology. 2006, 11: 520-522.

 

Wang J., Ho J.C.M., Lam W.K., Ip M.S.M., Chan M.M.W. and Tsang K.W.T., Lymphoepithelioma-like-carcinoma of the lung : experience with 13 cases, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2006, Abstract Book 104: pp. 59.

 

Wong M., Yasufuku K., Nakajima T., Motohashi S., Iyoda A., Suzuki M., Sekine Y., Shibuya K., Iizasa T., Hiroshima K., Tsang K.W.T., Ip M.S.M., Lam W.K. and Fujisawa T., Endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA) in the diagnosis of sarcoidosis, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2006, Abstract Book 092: pp. 57.

 

Wong M., Yasufuku K., Nakajima T., Motohashi S., Iyoda A., Suzuki M., Sekine Y., Shibuya K., Iizasa T., Hiroshima K., Tsang K.W.T., Lam W.K. and Fujisawa T., Endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA) in the diagnosis of sarcoidosis, American Journal of Respiratory and Critical Care Medicine. 2006, 173(3): A610.

 

Wong M.P., Chua D.T.T., Ho J.C.M., Tam I.Y.S., Lam W.K. and Chung L.P., Mutational status of epidermal growth factor receptor is the only predictor of clinical response to gefitinib treatment in non-small cell lung cancer, 97th AACR Annual Meeting, Washington, DC, April 1-5, 2006 . 2006.

 

Zhu H., Lam D.C., Han K.C., Tin P.C., Suen W.S., Wang E., Lam W.K., Cai W.W., Chung L.P. and Wong M.P., High resolution analysis of genomic aberrations by metaphase and array comparative genomic hybridization identifies candidate tumour genes in lung cancer cell lines, Cancer Letters. 2006.

 

Researcher : Lan HY



Project Title:

Role of smad signaling in regulation of CTGF expression under diabetic conditions

Investigator(s):

Lan HY

Department:

Medicine

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

05/2006

 

Abstract:

The main objectives of this project are to: (1) examine the regulating role of Smad signaling in CTGF expression under diabetic; (2) dissect the specific role of Smad2 and Smad3 in regulating CTGF expression under diabetic conditions.

 

List of Research Outputs

 

Researcher : Lau CP



Project Title:

Evaluation of the antianginal efficacy and safety of oral chronic administration of ivabradine (5mg b.i.d. then 7.5mg b.i.d or 10mg b.i.d) compared to atenolol (50mg o.d then 100mg o.d), in patients with stable effort angina pectorals

Investigator(s):

Lau CP, Lee KLF, Lee P.Y.

Department:

Medicine

Source(s) of Funding:

Other Funding Scheme

Start Date:

05/2000

 

Abstract:

To demonstrate the non-inferiority of invabradine 7.5mg b.i.d then 10mg b.i.d in improving exercise capacity in comparison to atenolol given by oral route for 4 and a half months to out-patients with chronic stable angina; to determine pharmacokinetic parameters.

 

Project Title:

Roles of macrophage migration inhibitory factor (MIF) in acute myocardial infarction

Investigator(s):

Lau CP, Yu CM, Lan HY

Department:

Medicine

Source(s) of Funding:

Low Budget High Impact Programme

Start Date:

11/2000

 

Abstract:

To investigate the pathogenic role and mechanism of macrophage migration inhibitory factor (MIF) after myocardial infarction (AMI).

 

List of Research Outputs

 

Chan Y.H., Lau K.K., Li S.W., Shu X.O., Lau C.P. and Tse H.F., Lower level of phytoestrogen intake correlates with poorer vascular endothelial function in patients with high risk for cardiovascular events, European Heart Journal. 2006, 27: 291.

 

Chen W.H., Kaul U., Leung S.K., Lau Y.K., Tan H.C., Leung A.W., Lee M.K., Li S.K., Ng W., Lee P.Y., Lam K.F., Tse H.F. and Lau C.P., A randomized, double-blind, placebo-controlled trial of abciximab for prevention of in-stent restenosis in diabetic patients after coronary stenting: results of the ASIAD (Abciximab in Stenting Inhibitis restenosis Among Diabetics) Trial, J Invasive Cardiol. 2005, 17(10): 534-8.

 

Cheung B.M.Y., Manil Y.B., Tse H.F., Kumana C.R. and Lau C.P., Advantages of blood pressure optimization, Adv Ther. 2005, 22(4): 285-96.

 

Cheung B.M.Y., Leung R.Y.H., Man Y.B., Ong K.L., Wong L.Y.F., Lau C.P. and Lam K.S.L., Association of hypertension with single nucleotide polymorphisms in the quantitative trait locus for abdominal obesity-metabolic syndrome on chromosome 17, J Hum Hyperten. 2006.

 

Cheung B.M.Y., Wong Y.L. and Lau C.P., British Journal of Clinical Pharmacology, Queen Mary Utilisation of Antihypertensive Drugs Study: Use of Antihypertensive Drug Classes in the Hypertension Clinic 1996-2004. 2005, 30: 391-399.

 

Cheung B.M.Y., Chau J., McGhee S.M., Lauder I.J., Lau C.P. and Kumana C.R., Cost-effectiveness of Statins for Coronary Heart Disease Patients with Hypercholesterolaemia, Hong Kong Medical Journal. China, Scientific Communications International, Ltd., 2006, 12(2) Supplement: 20-23.

 

Cheung B.M.Y., Cheung G.T.Y., Lauder I.J., Lau C.P. and Kumana C.R., Meta-analysis of Large Outcome Trials of Angiotensin Receptor Blockers in Hypertension, Journal of Human Hypertension. 2006, 20(1): 37-43.

 

Cheung B.M.Y., Ong K.L., Man Y.B., Lam K.S.L. and Lau C.P., Prevalence, Awareness, Treatment, and Control of Hypertension: United States National Health and Nutrition Examination Survey 2001-2, Journal of Clinical Hypertension. United States, Elsevier, 2006, 8: 93-98.

 

Cheung B.M.Y., Lo J.L., Fong H.Y., Chan M.Y., Wong S.H., Wong C.M., Lam K.S.L., Lau C.P. and Karlberg J.P.E., Randomised controlled trial of qigong in the treatment of mild essential hypertension, J Hum Hypertens. 2005, 19: 697-704.

 

Deng X., Lau C.P. and Li G.R., Cell-cycling dependent expression of potassium channels of rat mesenchymal stem cells from bone marrow., Journal of Hong Kong College Cardiology/The 9th Institute of Cardiovascular Science and Medicine & the 5th Scientific Conference on Cardiovascular Science Across the Strait. 2005, 13: 99-OP14.

 

Deng X., Sun H., Lau C.P. and Li G.R., Modulation of voltage-gated delayed rectifier potassium channels by EGFR-mediated kinase and relation to cell proliferation in mesenchymal stem cells from rat bone marrow, 11th Medical Research Conference, The University of Hong Kong/Queen Mary Hospital . 2006.

 

Dong M., Lau C.P., Gao Z., Tseng G.N. and Li G.R., Characterization of recombinant human cardiac KCNQ1/KCNE1 channels (I (Ks)) stably expressed in HEK 293 cells, In: 2006 Apr;Epub 2006 Aug 14., J Membr Biol.. 2006, 210: 183-192.

 

Hu R., Lee P.Y., Lau C.P. and Tse H.F., Impaired Nitrate-Medicated Dilatation Could Reflect Nitrate Tolerance and Predicted Need of Revascularization, JACC. 2006, 1000-159.

 

Hu R., Zhang X.X., Wang W.Q., Lau C.P. and Tse H.F., Smoking, homocysteine and degree of arteriolar retinopathy., Atherosclerosis . 2005, 183(1): 95-100.

 

Lau C.P., " Joint Clinical Symposium " New Diagnostic & Therapeutic Techniques for Aging Diseases" Topic: Prevention of atherosclerosis in the 21st century: What have we learned from recent clinical trials? , Research Centre on Heart, Brain, Hormone and Healthy Aging and Mayo Clinic, HKU. Hong Kong, 2005.

 

Lau C.P., DEVICES XIV: Pacing New Technologies and Clinical Insights, 27th Annual Scientific Meeting Heart Rhythm Society . 2006.

 

Lau C.P., Lee K.L.F., Tse H.F., Echt D., Heaven D., Smith W. and Hood A., First Acute demonstration leadless pacing in patients using acoustic energy, Heart Rhythm. 2006, 3: S102.

 

Lau C.P., Lee K.L.F., Tse H.F., Echt D., Heaven D., Smith W. and Hood M., First acute demonstration of leadless pacing in patients using acoustic energy, Europace. 2006, 3/5.

 

Lau C.P., New energy sources for AF ablation, The 8th South China International Congress of Cardiology. 2006.

 

Lau C.P., Statin’ in ‘Andiotensin, Fat and Nerves: New Targets for Atrial Antiarrhythmic Therapy’ “The Approach in the Pacific Rim “ in “Primary Prevention of Sudden Cardiac Death: An International Perspective : The Approach in the Pacific Rim”, 27th Annual Scientific Meeting Heart Rhythm Society . 2006.

 

Lau C.P., Syncope in the Elderly: Diagnosis and Management, 11th Hong Kong Medical Forum. 2006.

 

Lau C.P., The appropriate site of RV pacing, The 38th Annual Scientific Meeting of The Heart Association of Thailand under the Royal Patronage. 2006.

 

Lau E.O.Y., Tse H.F., Chan R.H.W., Chen W.H., Lee P.Y., Lee S.W.L., Chwang A.T.Y. and Lau C.P., Prediction of aortic augmentation index using radial pulse transmission-wave analysis, Journal of Hypertension. Lippincott Williams & Wilkins, 2006, 24(4): 723-730.

 

Lee K.L.F., Tse H.F., Mullen T.J., Burnes J.E. and Lau C.P., LV pacing before intrinsic RV conduction results in improved RV hemodynamics, Europace. 2006, 18P/21.

 

Lee P.Y., Chen W.H., Ng W., Cheng X., Tse H.F., Lau C.P. and Kwong J.Y., Low-dose aspirin increase aspirin resistance in patients wtih coronary artery disease, Am J Med 2005. 2005, 118: 723-7.

 

Li G.R., Deng X., Sun H., Chung S.S.M., Tse H.F. and Lau C.P., Ion channels in mesenchymal stem cells from rat bone marrow. , Stem Cells. 2006, 24: 1519-1528.

 

Li G.R., Liu H. and Lau C.P., Modulation of cardiac voltage-gated sodium current by the interplay of protein tyrosine kinase and phosphatases, Biophyscal Journal. 2006, 90: 435a-436a.

 

Liu H., Jin M.W., Xiang J.Z., Huang Y., Chiu S.W., Lau C.P. and Li G.R., Effects of raloxifene on action potential, transient outward and ultra-rapid delayed rectifier potassium current in human atrial myocytes., Journal of Hong Kong College Cardiology/The 9th Institute of Cardiovascular Science and Medicine & the 5th Scientific Conference on Cardiovascular Science Across the Strait. 2005, 13:111-OP60.

 

Ng W., Wong R.W.M., Chen W.H., Tse H.F., Lee P.Y., Lai K.C., Li L.S.W., Ng M.M.T., Lam K.F., Cheng X. and Lau C.P., Incidence and predictors of upper gastrointestinal bleeding in patients receiving low-dose aspirin for secondary prevention of cardiovascular events in patients with coronary artery disease, World Journal of Gastroenterology. Beijing, China, The WJG Press, 2006, 12(18): 2923-2927.

 

Siu C.W.D., Jim M.H., Kung A.W.C., Lau C.P. and Tse H.F., The Outcomes of Thyrotoxicosis Related New-Onset Atrial Fibrillation, JACC. 2006, 47: 10A.

 

Siu D.C.H., Yeung C.Y., Kung A.W.C., Lau C.P. and Tse H.F., Prevalence, clinical characteristics and outcomes of thyrotoxic dilated cardiomyopathy as the initial presentation in patients with thyrotoxicosis, American Heart Association Annual Scientific Meeting, 13-16 November 2005, Dallas, USA. 2005.

 

Tao R., Lau C.P. and Li G.R., Functional ion channel expression in mouse bone marrow derived mesenchymal stem cells, Journal of Hong Kong College Cardiology/The 9th Institute of Cardiovascular Science and Medicine & the 5th Scientific Conference on Cardiovascular Science Across the Strait. 2005, 13:120-OP94.

 

Tao R., Lau C.P. and Li G.R., InsP3 receptor-mediated calcium oscillation regulates proliferation and differentiation of human mesenchymal stem cells from bone marrow, 11th Medical Research Conference, The University of Hong Kong/Queen Mary Hospital. 2006.

 

Tao R., Lau C.P. and Li G.R., Ion channels in mouse bone marrow derived mesenchymal stem cells, 10th Research Postgraduate Symposium, Faculty of Medicine, HKU. 2005.

 

Tian M., Dong M., Chiu S.W., Lau C.P. and Li G.R., Effects of the antifungal antibiotic clotrimazole on human cardiac repolarization potassium currents. , British Journal of Pharmacology. 2006, 147: 289-297.

 

Tse H.F., Lee K.L.F., Wan S.H., Yu Y., Walter H., Pastore J., Zhu Q., Kenknight B., Spinelli J. and Lau C.P., Area of left ventricular regional conduction delay and preserved myocardium predict response to cardiac resynchronization therapy., J Cardiovasc Electrophysiol. 2005, 16: 690-5.

 

Tse H.F., Lam Y.M., Tang M.O., Tsang V.Y.C., Siu C.W.D. and Lau C.P., Avoidance of Left Ventricularof Dyssnchrony Detected by Tissue Doppler Echocardiography by Permanent Right Ventricular Septal Pacing in Patients with High Grade atrioventricular block, JACC. 2006, 47: 23A.

 

Tse H.F., Xue T., Lau C.P., Siu C.W.D., Wang K., Zhang Q.Y., Tomaselli G.F., Akar F.G. and Li R.A., Bioartifical sinus node constructed via in vivo gene transfer of an engineered pacemaker HCN channel reduces the dependence on electronic pacemaker in a sick sinus syndrome model, Circulation. 2006, 114: 1000-1011.

 

Tse H.F. and Lau C.P., Catheter ablation for persistent atrial firillation: are we ready for "prime time"?, J Cardiovasc electrophysiol. 2005, 16(11): 1148-9.

 

Tse H.F., Hettrick D.A., Mehra R. and Lau C.P., Improved atrial mechanical efficiency during alternate-and multiple site atrial pacing compared with conventional right atrial appendage pacing: implications for selective site pacing to prevent atrial fibrillation, J Am Coll Cardiol . 2006, 47(1): 209-12.

 

Tse H.F., Garg A., Bohn D., Lee Y.L. and Lau C.P., Muscle noise effects on atrial evoked response sensing: implication on atrial auto threshold, Europace. 2006, 8 Supplement 1: 43/5.

 

Tse H.F. and Lau C.P., Selection of permanent ventricular pacing site: how far should we go?, J Am Coll Cardiol 2006. 2006, 48: 1649-1651.

 

Tse H.F., Siu C.W.D., Lee K.L.F., Fan K., Chan H., Tang M.O., Tsang V.Y.C., Lee S.W.L. and Lau C.P., The incremental benefit of rate-adaptive pacing on exercise performance during cardiac resynchronization therapy., J Am Coll Cardiol . 2005, 46(12): 2292-7.

 

Tse H.F., Lau C.P., Bloomfield D.M., Park E., Bornzin G.A., Benser M.E., Padeletti L. and Yu C., Transient overdrive pacing prevents orthostatic hypotension in elderly pacemaker patients with chronotropic incompetence, Heart Rhythm. 2006, 3: S246.

 

Wang K., Xue T., Tsang S.Y., Huizen R.V., Wong C.W., Lai K.W.H., Ye Z., Cheng L., Zhang J.C.L., Li G.R., Lau C.P., Tse H.F. and Li R.A., Electrophysiological Properties of Pluripotent Human and Mouse Embryonic Stem Cells, Stem Cells. 2005, 23: 1526-1534.

 

Wang S.L., Ooi C.G., Siu C.W., Yiu M.W., Pang C. and Lau C.P., Pacing Clin Electrophysiol, Endocardial visualization of esophageal-left atrial anatomic relationship by three-dimensional multidetector computed tomography "navigator imaging". 2006, 29(5): 502-8.

 

Yiu K.H., Siu C.W.D., Lee K.L.F., Lam L., Chan R.H.W., Lee S.W.L., Lau C.P. and Tse H.F., Adverse Clinical Outcomes in Left-sided Infective Endocarditis Complicated Intravenous drug addict, JACC . 2006, 47: 281A.

 

Yiu K.H., Lau C.P., Lee K.L.F. and Tse H.F., Emerging energy sources for catheter ablation of atrial fibrillation, J Cardiovasc Electrophysiol. 2006, 17: S56-61.

 

Yiu K.H., Miu R., Lee K.L.F., Yung L.Y., Siu C.W.D., Tse H.F., Lam B., Lam J., Ip M.S.M. and Lau C.P., Improvement of sleep Apnea in heart failure patients after cardiac resynchronization therapy is associated with a significant dop in pulmonary arterial pressure, Heart Rhythm. 2006, 3, No. 5: S87.

 

Yiu K.H., Lee K.L.F., Tse H.F., Siu C.W.D., Lam B., Ip M.S.M. and Lau C.P., Improvement of sleep apnea in heart failure patients after cardiac resynchronization therapy is caused by relief of pulmonary congestion as reflected by a drop of pulmonary arterial pressure, Europace. 2006, 10/6.

 

Yiu K.H., Miu K.M., Lee K.L.F., Tse H.F., Siu C.W.D., Lam K., Lam B., Ip M.S.M. and Lau C.P., Improvement of sleep apnea in heart failure patients after cardiac resynchronization therapy is caused by relief of pulmonary congestion sa reflected by a drop of pulmonary congestion as reflected by a drop of pulmonary arterial pressure, Europace . 2006, 8 Supplement 1: 10/6.

 

Yiu K.H., Siu C.W.D., Lee K.L.F., Lam L., Chan R.H.W., Lee S.W.L., Lau C.P. and Tse H.F., Temporal Trend of Infective Endocarditis in Chinese: A Population Based Study Over 10 Years Period, JACC. 2006, 984-24.

 

Zhan H., Tse H.F., Cao J.M. and Lau C.P., Comparative study on characteristics of congestive heart failure patietns with preserved versus abnormal left ventricular systolic function and evaluation effects of therapy, Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. . 2006, 18(4): 210-5.

 

Zhang D., Lau C.P. and Li G.R., A depolarization-induced transient outward component in inward-rectifier potassium current is regulated by intracellular Mg2+ and spermine. , Journal of Hong Kong College Cardiology/The 9th Institute of Cardiovascular Science and Medicine & the 5th Scientific Conference on Cardiovascular Science Across the Strait. 2005, 13:130-OP130.

 

Zhang D., Lau C.P. and Li G.R., A depolirization-activated transient outward current is contributed by recombinant human cardiac Kir2.1 channels expressed in HEK 293 cells , 10th Research Postgraduate Symposium, Faculty of Medicine, HKU. 2005.

 

Zhang D., Lau C.P. and Li G.R., Regulation of human cardiac inwardly-rectifying Kir2.1 channels by tyrosine kinase phosphorylation, 11th Medical Research Conference, The University of Hong Kong/Queen Mary Hospital. 2006.

 

Zhang Q.Y., Wei M., Ge J.B., Qian J.Y. and., Lau C.P., Tse H.F., Increased mast cell accumulation and activity contribute to angiogenesis and preserve microvascular function after coronary microembilization, European Heart Journal. 2006, 27:291: 926.

 

Zhang Q.Y., Ge J.B., Chen J.Z., Zhu J.H., Zhang L.H., Lau C.P. and Tse H.F., Mast Cell Contributes to Cardiomyocyte Apoptosis after Coronary microembolization, J Histochem Cyochem. 2005, 54(5): 515-23.

 

Researcher : Lau G


Project Title:

Role of intrahepatic close-circular covalent (ccc) DNA in HBV reactivation in hepatitis B surface antigen positive subjects who received chemotherapy

Investigator(s):

Lau G, Liang RHS, He ML

Department:

Medicine

Source(s) of Funding:

Seed Funding Programme for Applied Research

Start Date:

11/2002

 

Abstract:

To study the T cell determinants of liver damages during the immune-clearance phase of chronic HBV infection.

 

Project Title:

Characterization of the HBV-specific cytotoxic T lymphocyte (CTL) activities associated with a sustained remission after anti-HBV therapy in Chinese with chronic HBV infection

Investigator(s):

Lau G, Lin CL, Zhang H

Department:

Medicine

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

02/2004

 

Abstract:

To compare the frequency and phenotype of the end-of-therapy virus-specific CD8+ T cells in chronic HBV patients who had sustained response to anti-HBV therapy with those who relapse; to compare the characteristics of end-of-therapy HBV-specific CD8+ T cells in those who were treated with nucleoside analogues, such as lamivudine, and those treated with immune therapy, such as pegylated interferon.

 

Project Title:

Prevalence and Natural History of Non-Alcoholic Fatty Liver Diseases in Hong Kong Chinese

Investigator(s):

Lau G

Department:

Medicine

Source(s) of Funding:

Hong Kong Liver Foundation - General Award

Start Date:

02/2005

 

Abstract:

To define teh prevalence of non-alcoholic fatty liver diseases (NAFLD) in Hong Kong Chinese; to charaterize the natural history of NAFLD in patients with and without chronic HBV infection.

 

List of Research Outputs

 

Behrsing H., Tam J., Park Y., Yun H., Do A., Gray B., Zhao D., Gropper C., Jung J., Gish R., Micguire B., Panoskaltsis-mortari A., Lau G., Yim Y.S., Lee H.C., Suh D.J. and Park S.P., In Virto Assessment of a Novel Porcine Liver Slice-Filled Bioartificial Liver (BAL) for Dialysis of Liver Failure Patients, J Gastroenterol and Hepatol. 2006, 21(2): A91.

 

Chan O.O., Hui W.M., Chan C.K., Lai K.C., Hu H.C., Yuen R.M.F., Wong R.W.M., Lau G., Hui C.K., Lam S.K. and Wong B.C.Y., Colonoscopy Demand and Practice in a Regional Hospital over 9 Years in Hong Kong: Resource Implication for Cancer Screening, Gastroenterology. 2006, 130 (4 Suppl 2): A-618.

 

Chan O.O., Hui W.M., Chan C.K., Lai K.C., Hu H.C., Yuen R.M.F., Wong R.W.M., Lau G., Hui C.K., Lam S.K. and Wong B.C.Y., Colonoscopy demand and practice in a regional hospital over 9 years in Hong Kong: Resource implication for cancer screening, Digestion. 2006, 73(2-3): 84-88.

 

Cooksley G., Lau G., Marcellin P., Piratvisuth T., Bonino F., Luo K.X., Hadziyannis S., Jin R., Button P. and Pluck N., Peginterferon Alpha-2az (40KD) (Pegasys) Reverses Cirrhosis, Improve Fibrosis and Slows Progression Of Fibrosis in Patients with HBe-Ag-Positive or HBeAg-Negative Chronic Hepatitis B (CHB), J Hepato. 2006, 44(2): S182.

 

Crooksley G., Chow W.C., Piratvisuth T., Lau G. and Mccloud P., Predicting Response to Peginterferon Alfa-2a (40KD)(PEGASYS) in Asian Patients with HBe-Ag - Positive Chronic Hepatitis B, J Gastroenterol and Hepatol. 2006, 21(2): A108.

 

Fried M.W., Liaw Y.F., Luo K.X., Lau G., Piratvisuth T., Cooksley G., Marcellin P., Flisiak R., Popescu M. and Button P., HBeAg and HBV Kinetics in HBsAg Clearance with Peginterferon Alpha-sa(40KD) (Pegasys) Treatment for HBeAg-Positive Chronic Hepatitis B (CHB), J Hepato. 2006, 44(2): S183.

 

Fried M.W., Lau G., Liaw Y.F., Luo K.X., Piratvisuth T., Cooksley G., Marcellin P., Thongsawat S. and Button P., Role of Baseline and on-treatment Quantitiative HBeAg in Prediciting Response to Peginterferon Alfra-2a (40KD) Monotherapy in Chronic Hepatitis B, J Gastroenterol and Hepatol. 2006, 21(2): A72.

 

Hui C.K., Lai L.S., Lam P., Zhang H., Fung T.T., Lai S.T., Wong W.M., Lo C.M., Fan S.T., Leung N. and Lau G., 48 weeks pegylated interferon alpha-2a is superior to 24 weeks of pegylated interferon alpha-2b in achieving hepatitis B e antigen seroconversion in chronic hepatitis B infection, Alimentary Pharmacology and Therapeutics. 2006, 23(8): 1171-1178.

 

Hui C.K., Lie A.K.W., Au W.Y., Leung A.Y.H., Ma S.Y., Cheung W.W., Zhang H., Chim J.C.S., Kwong Y.L., Liang R.H.S. and Lau G., A long-term follow-up study on hepatitis B surface antigen-positive patients undergoing allogeneic hematopoietic stem cell transplantation, Blood. 2005, 106(2): 464-9.

 

Hui C.K. and Lau G., Advances in immunomodulating therapy of HBV infection, International J Medical Sciences. 2005, 2: 24-29.

 

Hui C.K. and Lau G., Clevudine For Treatment Of Chronic Hepatitis B Virus Infection, Expert Opinion on Investigational Drugs. 2005, 14: 1277-1284.

 

Hui C.K. and Lau G., Clevudine for the treatment of chronic hepatitis B virus infection, Expert Opin Investig Drugs. 2005, 14(10): 1277-84.

 

Hui C.K., Bowden S., Zhang H., Wong A., Lewin S., Rousseau F., Mommeja-Marin H., Lee N.P., Luk J.M., Leung N., Naoumov N.V. and Lau G., Comparison of Real-Time PCR Assays for Monitoring serum HBV DNA levels during Antiviral Therapy, Journal of Clincial Microbiology. 2006, 44: 2983-2987.

 

Hui C.K. and Lau G., Current issues and future directions in treatment, Semin Liver Dis. 2006, 26(2): 192-7.

 

Hui C.K., Lau E., Kim M., Monto A., Luk J.M., Leung N., Lo C.M., Fan S.T., Wright T.L. and Lau G., Fibrosis Porgression in Patients with Recurrent Chronic Hepatitis C Virus and Occult Hepatitis B Co-Infection After Liver transplantation, J Gastroenterol and Hepatol. 2006, 21(2): A80.

 

Hui C.K., Lau E., Wu H., Monto A., Kim M., Luk J.M.C., Lau G. and Wright T.L., Fibrosis progression in chronic hepatitis C patients with occult hepatitis b co-infection, J Clin Virol . 2005, 35: 185-192.

 

Hui C.K., Lau E., Kim M., Monto A., Luk J.M.C., Leung N., Lo C.M., Fan S.T., Wright T.L. and Lau G., Fibrosis progression in patients with recurrent chronic hepatitis C virus and occult hepatitis B co-infection after liver transplantation (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A80.

 

Hui C.K., Cheung W., Au W.Y., Lie A.K.W., Zhang H., Yueng Y.H., Wong B.C.Y., Leung N., Kwong Y.L., Liang R.H.S. and Lau G., Hepatitis B reactivation after withdrawal of preemptive lamivudine in patients with hematological malignancy upon completion of cytotoxic chemotherapy, Liver International 2005. 2005, Oct: 182.

 

Hui C.K., Ma S.Y., Sun J., Au W.Y., Lie A.K.W., Chim J.C.S., Kwong Y.L., Liang R.H.S. and Lau G., Hepatitis B reactivation in patient with occult HBV infection after chemotherapy, J Hepatol. 2005, 42(6): 813-19.

 

Hui C.K. and Lau G., Immune system and hepatitis B virus infection, J Clin Virol. 2005, S44-8.

 

Hui C.K., Cheung W.W., Zhang H., Au W.Y., Yueng Y.H., Leung A.Y.H., Leung N., Luk J.M.C., Lie A.K.W., Kwong Y.L., Liang R.H.S. and Lau G., Kinetics and risk of de novo hepatitis B infection in HBsAg negative patients undergoing cytotoxic chemotherapy, Gastroenterology. 2006, 131: 59-68.

 

Hui C.K., Lau E., Monto A., Kim M., Luk J.M.C., Poon R.T.P., Leung N., Lo C.M., Fan S.T. and Lau G., Natural history of patients with recurrent chronic hepatitis C virus and occult hepatitis B co-infection after liver transplanation, AM J Transplanation. 2006, 6(7): 1600-8.

 

Hui C.K. and Lau G., Peginterferon-alpha2a (40kDa) (Pegasys) for hepatitis B, Expert Rev Anti Infect Ther. UK, Future Drugs, 2005, 3: 495-504.

 

Hui C.K., Cheung W.W., Zhang H., Au W.Y., Yueng Y.H., Leung A.Y.H., Leung N., Luk J.M.C., Lie A.K.W., Kwong Y.L., Liang R.H.S. and Lau G., Rituximab increases the Risk of De Novo hepatitis B infection in Hepatitis B Surface Antigen Negative Patients Undergoing Cytotoxic Chemotherapy, J Gastroenterol and Hepatol. 2006, 21(2): A73.

 

Hui C.K. and Lau G., The present and future therapy for chronic hepatitis B infection, Seminar in Liver Diseases (invited review). 2006, 26(2): 192-7.

 

Hui C.K., Bowden S., Lewin S., Locarnini S., Naoumov N.V. and Lau G., The use of Real-Time PCR Assays for Monitoring Hepatitis B Virus DNA Response ot Antiviral Therapy, J Clinical Microbiology. 2006, 44(8): 2983-7.

 

Hui C.K. and Lau G., Therapies for chronic hepatitis B virus infection, Hong Kong Pharmaceutical Journal. 2005, 14: 18-21.

 

Hui C.K., Zhan H.Y., Lee N.P., Yueng Y.H., Lu L., Leung N., Wong B.C., Lo C.M., Fan S.T., Luk J.M.C. and Lau G., Upregulation of toll-like receptor 7 is essential for serological clearance of hepatitis B surface antigen in chronic hepatitis B (HBV) infection, Hepatology. 2005, 42(4): 707A-708A, Suppl 1.

 

Hui C.K., Zhang H., Lee N.W., Lu L., Leung N., Wong B.C.Y., Lo C.M., Fan S.T., Luk J.M.C. and Lau G., Upregulation of toll-like receptor 7 is essential for serological clearance of hepatitis B surface antigen in chronic hepatitis B virus (HBV) infection, Liver International 2005. 2005, Oct: 196.

 

Janssen H.L. and Lau G., Chronic hepatitis B:HBeAg seroconversion after pegylated interferon and nucleos(t) ide analogs, Hepatology. 2005, 42(6): author reply 1459-60.

 

Jia J.D., Piratvisuth T., Lau G., Luo K.X., Jin R., Lu Z.M., Marcellin P., Popescu M. and Button P., Asian Patients with HBeAg- Negative Chronic Hepatitis B Respond Well to Peginterferon Alra-2A (PEGASYS) Treatment, J Gastroenterol and Hepatol. 2006, 21(2): A88.

 

Lai L.S.W., Fung T.T., Lai S.T., Yiu J., Lam P., Zhang H., Wong W.M., Lo C.M., Fan S.T., Hui C.K., Leung N. and Lau G., 48 weeks pegylated interferon alfa-2a is superior to 24 weeks of pegylated interferon alfa-2b in achieving HBeAg seroconversion in chronic hepatitis B infection (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A90.

 

Lai S.W., Fung S.T., Lai S.T., Yiu J., Lam P., Zhang H.Y., Wong W.M., Lo C.M., Fan S.T., Leung N. and Lau G., 48 Weeks Pegylated Interferon Alfa-2a is superior to 24 Weeks of Pegylated interferon Alfa-2b in Achieving HBeAg seroconversion in Chronic Hepatitis Infection, J Gastronenterol and Hepatol. 2006, 21(2): A90.

 

Lau G., "IFN therapy (Standard and pegdylated interferons) and IFN-based combination therapies, Monothematic Conference "From Viral Pathobiology to the treatment of Hepatitis B virus infection of the European Assoication for the Study of the Liver (EASL) 6-8 Oct 2005, Turkey. 2005.

 

Lau G., "Overview of Current Options for HBV Treatment, CME Regional Conference - Emerging Treatments for Liver Disease and Complex GI Diseases. 2005.

 

Lau G., Annual Scientific meeting and National Endoscopy workshop, GIHep Singapore 2006, 2006.

 

Lau G., Asia Pacific Viral Hepatitis B Forum , Introducing PEGASYS – the new choice for lasting remission in patients with chronic hepatitis B. 2005.

 

Lau G., Bone Marrow Transplantation and Chemotherapy , Management of Chronic Hepatits B: 2006 by the National Instiute of Health (6-8 April 2006 Bethesda, USA). 2006.

 

Lau G., Chairman, Hepatitis B Session, American Association for the study of liver diseases 2005 (San Fancisco, USA 14th Nov 2005). 2005.

 

Lau G., Chairperson, 16th Asian Pacific Assocation for the Study of the Liver (APASL) 2006 Manila Philippines. 2006.

 

Lau G., Chairperson, Bridging the Sciences 2006: HIV/HBV/HCV Infections and Emerging Virsus (31st May -3rd June 2006, Paris, France). 2006.

 

Lau G., Chairperson, Hong Kong Shanghai International Liver Congress 2006 (25-28 Mar, 2006, Shanghai). 2006.

 

Lau G., Chairperson, The Fourth Consortium meeting for globalization of Chinese medicine (National Health researach Institutes, Taiwan 27-29 Aug 2005). 2005.

 

Lau G., Charman, Hong Kong Association for the study of the Liver 2005 Annual Meeting (25-26 Nov 2005). 2005.

 

Lau G., Chronic Hepatitis B: Consolidating clinical knowledge for improved outcomes, American Assoication for the Study of Liver Diseases 2005 (11th-12 Nov, 05) San Franciso, USA. 2005.

 

Lau G., Piratvisuth T., Luo K.X., Marcellin P., Thongsawat S., Cooksley G., Gane E., Fried M.W., Popescu M. and Wu J., Durability of Response and occurrence of Late Response to Peginterferon Alpha-2A(40KD) (Pegasys) One year Post-Treatment in Patients with HBe-Ag-Positive Chronic Hepatitis B, J Hepato. 2006, 44(2): S23.

 

Lau G., Luo K.X., Paik S.W., Chang W.Y., Piratvisuth T., Chutaputti A., Yin Y.K. and McCloud P., Effect of age, gender, prior anti-HBV therapy and drug exposure on sustained response in Asian patients enrolled in a large multinational study peginterferon alfa-2a (40KD)+/- lamivudine for chronic hepatitis B, Liver International 2005. 2005, Oct: 200.

 

Lau G., HBV DNA Kinetics: Can we apply a prediction rule, The 16th Conference of the Asian Pacific Association for the study of the Liver (5-8th March 2006, Manila, Philippines). 2006.

 

Lau G., I. Chronic hepatitis B-initiating treatment nowadays II. Therapy of chronic hepatitis B in immunosuppressed patients (State-of-the-Art lecture) III. New therapeutic agents in the control of hepatitis B , XVIII Congress Brasileiro de Hepatologia-Ca 2005. 2005.

 

Lau G., I. The Arrival of PEGASYS for CHB – the New Choice for Lasting Remission II. Debate IV: Hepatitis C Treatment with Normal ALT Pro & Con III. Reactivation of Hepatitis B: Current Issues and Management, 15th Conference of Asian Pacific Association for the Study of the Liver (APASL) . 2005.

 

Lau G., Immunological issues in HBV viral clearance, Center for study of liver Diseases (21st Jan 2006). 2006.

 

Lau G., Plenary lecture"Suppressing HBV replication with new drugs and combinations, Bridging the Sciences 2006: HIV/HBV/HCV infections and emerging viruses (31May - 3rd June, 2006, Paris, France). 2006.

 

Lau G., Plenary lecture: Chronic hepatitis B treatment-an-updates, 2006 Romanian National Gastroenterology and Hepatology Congress (14-17 June, 2006 Poiana Brasov Romania). 2006.

 

Lau G., Pre-emptive therapy for hepatitis B prior to chemotherapy, Asian Pacific Association for the Study of the Liver (APASL) 2004. 2005.

 

Lau G., The update of Peginterferon alfa-2a in HBeAf positive CHB, 2006 Chinese Hepatology Annual Meeting (11th - 12nd May 2006 Daliang, China). 2006.

 

Lau G., Therapy of HBV infection, Phoenix Society of Gastroenterology 2005. 2005.

 

Lau G., Treatment of Hepatitis B Antigen Positive Diseases , Hong Kong - Shanghai International Liver Congress 2006 (25th - 28th Mar 2006, Shanghai). 2006.

 

Lau G., Treatment of chronic hepatitis B in immunosuppressed patients, 6th liver update by Malaysian Liver Foundation (21-24th July 2005, Kuala Lumpur, Malaysia). 2005.

 

Lau G., Treatment of chronic hepatitis B: new data on Pegasys", Hong Kong Medical Forum (July 2005). 2005.

 

Lau G., 八成肝癌源於乙型肝炎, 明報, 2005.

 

Lau G., 乙型肝炎治療新突破, 都市日報, 2005.

 

Lee P.Y., Leung K.W., Sham P.C., Lau G., Fan S.T. and Luk J.M., Proteomic Expression Clustering of Mourse Liver Development Stages, J Gastroenterol and Hepatol . 2006, 21(2): A218.

 

Lee P.Y., Leung K.W., Sham P.C., Lau G., Fan S.T. and Luk J.M.C., Proteomic expression clustering of mouse liver developmental stages (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A218.

 

Lin M.C., Lee P.Y., Zheng N., Yang P., Wong O.G., Kung H.F., Hui C.K., Luk J.M.C. and Lau G., Tumor necrosis factor-a-induced protein 1 and immunity to hepatitis B virus, World Journal of Gastroenterology. 2005, 11(48): 7564-8.

 

Lo C.M., Liu C.L., Lau G., Fan S.T. and Chan S.C., Failure of hepatitis B vaccination in patients receiving lamivudine prophylaxis after liver transplantation for chronic hepatitis B, Journal of Hepatology. 2005, 43(2): 283-287.

 

Lo C.M., Cheung C.K.Y., Lau G., Yuen R.M.F., Liu C.L., Chan S.H.C., Fan S.T. and Wong J., Significance of hepatitis B virus genotype in liver transplantation for chronic hepatitis B, American Journal of Transplantation. Blackwell, 2005, 5: 1893-900.

 

Lu L., Hui C.K., Zhang H., Yueng Y.H., Cheung K.F. and Lau G., Quantification and Correlation of HBV DNA and RNA inPeripheral Blood Mononuclear Cells adn HBV DNA in Serum in Chronic Hepatitis B, J Gastroenterol and Hepatol. 2006, 21(2): A77.

 

Luk J.M.C., Chen L., Lam B.K.Y., Ho D.W.Y., Peng J.R., Leng X.S., Hui C.K., Lau G., Yip T.T. and Fan S.T., Comparing serum alpha-fetoprotein level and SELDI-TOF-MS profiling for diagnosis of hepatocellular carcinoma (Abstract), The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2-3 December 2005.

 

Luk J.M.C., Chen L., Lam B., Ho D., Peng J., Leng J., Leng X., Hui C.K., Lau G., Yip T.T. and Fan S.T., Comparing serum alpha-fetoprotein level and SELDI-TOF-MS profilling for diagnosis of hepatocellular carcinoma. The 4th JSH Single Topic conference on hepatocellular carcinoma. , Hoyogo, Japan. 2005, Dec2-3, 05.

 

Luk J.M.C., Wang X., Garcia-Barcelo M.M., Leung P.P., Lam B.K.Y., Ho D.W.Y., Yu W.C., Hui C.K. and Lau G., Genetic polymorphisms of liver intestine-cadherin CDH17 are associated with alternative mRNA splicing and increased risk of hepatocellular carcinoma (Abstract), Hepatology. 2005, 42(4): 307A-308A Suppl 1.

 

Luk J.M.C., Zhang Q., Wo J., Leung P.P., Hu M.Y., Lau G. and Fan S.T., Hepatic stellate cell-targeted delivery of 18beta-glycyrrhetinic acid modulates bile duct ligation-induced fibrosis in rat liver, Hepatology. 2005, 42(4): 266A-266A Suppl 1.

 

Marcellin P., Lau G., Piratvisuth T., Jin R., Lu Z.M., Lai M.Y., Thongsawat S., Ramakrishnan B. and Popescu M., Responses to Peginterferon Alfa-2a (40KD) (PEGASYS) treatment are durable in Asian Patients with HBeAg-Negative CHB: 12 month Follow-Up Data from a large Randomised Study, J Gastroenterol and Hepatol. 2006, 21(2): A140.

 

Marcellin P., Bonino F., Lau G., Farci P., Yurdaydin C., Piratvisuth T., Jin R., Gurel S., Hadziyannis S., Lu Z.M. and Popsesu M., The Majority of Patients with HBeAg-Negative Chronic Hepatitis B Treated with Peginterferon Alpha-2a (40KD) (Pegasys) Sustain Responses 2 Years Post-Treatment, J Hepato. 2006, 44(2): S275.

 

Piratvisuth T., Lau G., Marcellin P., Chow W.C., Cooksley G., Fried M.W., Paik S.W., Liaw Y.F., Popescu M. and Button P., Association between HBe-Ag Seroconversion and Sustained HBV-DNA Suppression in Patients treated with Peginterferon Alpha-2a(40KD) (Pegasys) for HBeAg-Positive Chronic Hepatitis B (CHB), J Hepato. 2006, 44(2): S23.

 

Song K., Rajvanshi P., Orlent H. and Lau G., Treatment of HBeAg-Positive Hepatitis B with Peginterferon and Lamivudine, N Engl J Med. 2005, 353: 1630-31.

 

Wang Z., Lau G., Zhu W. and Chao C., Influence of test capacitor features on piezoelectric and dielectric measurement of ferroelectric films, IEEE Trans ultrason Ferroelectr Freq Control. 2006, 53(1): 15-22.

 

Zhang H., Hui C.K., Wong A., Lee N.P., Leung N., Luk J.M.C. and Lau G., Comparison of Real-Time PCR Assays for monitoring Serum HBV DNA Levels During Antiviral Therapy, J Gastroenterol and Hepatol. 2006, 21(2): A140.

 

Zhu R., Lau G., Chiu J. and He Q., Proteomics profiling of human serum for biomarker detection of the progression from hepatitis B virus to hepatocellular carcinoma, The 230th National Meeting of the American Chemical Society, Washington DC., Aug 28 - Sept 1. 2005.

 

Researcher : Lau GKK



Project Title:

Role of intrahepatic close-circular covalent (ccc) DNA in HBV reactivation in hepatitis B surface antigen positive subjects who received chemotherapy

Investigator(s):

Lau G, Liang RHS, He ML

Department:

Medicine

Source(s) of Funding:

Seed Funding Programme for Applied Research

Start Date:

11/2002

 

Abstract:

To study the T cell determinants of liver damages during the immune-clearance phase of chronic HBV infection.

 

Project Title:

Characterization of the HBV-specific cytotoxic T lymphocyte (CTL) activities associated with a sustained remission after anti-HBV therapy in Chinese with chronic HBV infection

Investigator(s):

Lau G, Lin CL, Zhang H

Department:

Medicine

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

02/2004

 

Abstract:

To compare the frequency and phenotype of the end-of-therapy virus-specific CD8+ T cells in chronic HBV patients who had sustained response to anti-HBV therapy with those who relapse; to compare the characteristics of end-of-therapy HBV-specific CD8+ T cells in those who were treated with nucleoside analogues, such as lamivudine, and those treated with immune therapy, such as pegylated interferon.

 

Project Title:

Prevalence and Natural History of Non-Alcoholic Fatty Liver Diseases in Hong Kong Chinese

Investigator(s):

Lau G

Department:

Medicine

Source(s) of Funding:

Hong Kong Liver Foundation - General Award

Start Date:

02/2005

 

Abstract:

To define teh prevalence of non-alcoholic fatty liver diseases (NAFLD) in Hong Kong Chinese; to charaterize the natural history of NAFLD in patients with and without chronic HBV infection.

 

List of Research Outputs

 

Researcher : Lau HL



List of Research Outputs

 

Lau H.L., Ng M.Y.M., Cheung W.M.W., Paterson A.D., Sham P.C., Luk K.D.K., Chan V.N.Y. and Kung A.W.C., Assessment of linkage and association of 13 genetic loci with bone mineral density, Journal of Bone and Mineral Metabolism. 2006, 24: 226-34.

 

Lau H.L., Ng M.Y.M., Jin L., Paterson A., Sham P.C., Luk K.D.K., Chan V.N.Y. and Kung A.W.C., Test of linkage and association of 14 genetic loci with bone size, 27th Annual Meeting of the American Society for Bone & Mineral Research, 23-27 September 2005, Nashville, USA. 2005.

 

Researcher : Lau HL



List of Research Outputs

 

Lau H.L., Ng M.Y.M., Cheung W.M.W., Paterson A.D., Sham P.C., Luk K.D.K., Chan V.N.Y. and Kung A.W.C., Assessment of linkage and association of 13 genetic loci with bone mineral density, Journal of Bone and Mineral Metabolism. 2006, 24: 226-34.

 

Lau H.L., Ng M.Y.M., Jin L., Paterson A., Sham P.C., Luk K.D.K., Chan V.N.Y. and Kung A.W.C., Test of linkage and association of 14 genetic loci with bone size, 27th Annual Meeting of the American Society for Bone & Mineral Research, 23-27 September 2005, Nashville, USA. 2005.

 

Researcher : Lau KK



List of Research Outputs

 

Chan Y.H., Lau K.K., Li S.W., Shu X.O., Lau C.P. and Tse H.F., Lower level of phytoestrogen intake correlates with poorer vascular endothelial function in patients with high risk for cardiovascular events, European Heart Journal. 2006, 27: 291.

 

Researcher : Lau KS



List of Research Outputs

 

Kung A.W.C., Lau K.S., Cheung W.M.W. and Chan V.N.Y., Thyrotoxic periodic paralysis and polymorphisms of sodium-potassium ATPase genes, Clin Endocrinol (Oxf). 2006, 64: 158-61.

 

Researcher : Lau SK



List of Research Outputs

 

Yung S.S.Y., Lee Y.Y.C., Zhang Q., Leung J.K.H., Lau S.K., Tsang R.C.W. and Chan D.T.M., Elevated glucose concentrations induce thrombospondin-1 synthesis in proximal renal tubular epithelial cells thereby stimulating fibronectin synthesis through TGF-b1 dependent and TGF-b1 independent pathways, Nephrology Dialysis Transplantation. 2006, 21: 1504-1513.

 

Researcher : Lau WCS



Project Title:

Prospective study of the clinical pattern of systemic lupus erythematosus in Hong Kong

Investigator(s):

Lau WCS

Department:

Medicine

Source(s) of Funding:

Other Funding Scheme

Start Date:

01/1993

 

Abstract:

To study the clinical pattern of systemic lupus erythematosus in Hong Kong.

 

Project Title:

Effects of sex hormones on lymphocyte function in systemic lupus erythematosus

Investigator(s):

Lau WCS, Mok TMY

Department:

Medicine

Source(s) of Funding:

Small Project Funding

Start Date:

11/2002

 

Abstract:

To examine the effects of estrogen, testrogen, testosterone and prolactin on SLE peripheral T- and B-lymphocyte apoptosis and function. Menstruating and postmenopausal female patients and male patients will be studied.

 

Project Title:

A study to evaluate the immunopathology of Severe Acute Respiratory Syndrome

Investigator(s):

Lau WCS, Chan EYT, Cheung BMY

Department:

Medicine

Source(s) of Funding:

VCO SARS Research Fund

Start Date:

07/2003

 

Abstract:

To investigate the time course of changes in cytokines in patients with SARS; to investigate the relationship between clinical deterioration and changes in the serum/plasma levels of cytokines; to evaluate the cytokine expression in post-mortem lung tissues of patients with SARS will be studied.

 

Project Title:

Evaluation of the effects of sex hormones on neutrophils and macrophage apoptosis and macrophage phagocytic clearance of apoptotic neutrophils in systemic lupus erythematosus

Investigator(s):

Lau WCS

Department:

Medicine

Source(s) of Funding:

Small Project Funding

Start Date:

11/2003

 

Abstract:

To study the effects of oestrogen and progesterone on the rate of apoptosis and secondary necrosis of PMN and M[phi] in SLE patients and controls; to study the effects of oestrogen and progesterone on the ability of phagocytic M[phi] to clear apoptotic bodies in patients with SLE and controls.

 

Project Title:

Complement deficiency and dendritic cell function in the pathogenesis of systemic lupus erythematosus

Investigator(s):

Lau WCS

Department:

Medicine

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

10/2004

 

Abstract:

To determine their phenotypic expression i.e. stage of maturity; to study their functional activity through intracellular cytokine detection; to study their capability to phagocytose apoptotic cells and their subsequent functional changes; to evaluate the effects of various complement factors including C1q, C2, C3, C4 and mannose binding lectin on their uptake of apoptotic cells; to determine their interactions with T-cells following ingestion of apoptotic cells and to delineate the subsequent changes in T-cell activity through intracellular cytokine detection.

 

Project Title:

Complement deficiency and dendritic cell function in the pathogenesis of systemic lupus erythematosus

Investigator(s):

Lau WCS

Department:

Medicine

Source(s) of Funding:

Merit Award for RGC CERG Funded Projects

Start Date:

01/2005

 

Abstract:

N/A

 

Project Title:

Dendritic cell function and their effects on B cell activation in systemic lupus erythematosus

Investigator(s):

Lau WCS

Department:

Medicine

Source(s) of Funding:

Small Project Funding

Start Date:

12/2005

 

Abstract:

Disturbances in the process of apoptosis and the clearance of apoptotic cells, a major source of auto-antigens, have been suggested as the fundamental pathoaetiological mechanism of systemic lupus erythematosus (SLE) which is characterised by T and B cell activation. Excess apoptotic cells may be captured by dendritic cells (DCs) which may then undergo functional changes and influence the activity of other immune cells, particularly T cells. Previous studies on DCs in SLE have yielded conflicting results with some demonstrating a deficiency in DC function, particularly CD11c+ cells, while others showing SLE serum was capable of inducing DC differentiation and presentation of dying cells to CD4+ T cells. These discrepancies are probably related to the fact that (1) peripheral blood DCs exist in different subtypes with different roles in immune regulation; and (2) previous studies have generally generated DCs from peripheral blood mononuclear cells (PBMCs) cultured with granulocyte-macrophage colony-stimulating factor and interleukin-4, and stimulation with lipopolysaccharide. DCs generated and isolated by this method are not representative of circulating DCs. We now know that there are two main subtypes of peripheral blood DCs - plasmacytoid DCs (pDCs) and myeloid DCs (mDCs). pDCs are characterised by cell surface expression of CD4+, Lin-, CD11C-, CD123bright, CD45RA+, CD2- and BDCA-2+1, while mDCs have cell surface expression of CD4+, CD11cbright, CD123dim, CD45RO+ and CD2+. It is now possible to isolate pDCs and mDCs by positive selection. In one of our recent studies, we showed that mDCs were responsible for the maintenance of immune homoestasis by inducing Th-1 cytokine response, and pDCs in the induction of tolerance in healthy subjects. The number and functional activities of these 2 types of DCs appeared to be altered in SLE. SLE blood had a lower % of mDCs and higher % of pDCs of PBMCs, and SLE mDCs had lower surface CD83 expression when compared with controls. Unlike in healthy subjects, mDCs from SLE patients were less able to present non-self antigens to autologous T cells. On the other hand, SLE pDCs were capable of stimulating T cells in SLE. These results suggest that SLE pDCs have increased activity and this may contribute to the development of autoimmunity in this condition. Recent investigations have also shown DCs may directly interact with B cells in healthy subjects. However, this has not been studied in SLE. The primary objective of this investigation is to evaluate if DCs are capable of interacting directly with B-cells in the absence of T-cells in patients with SLE.

 

List of Research Outputs

 

Kumar D.S.S., Lau W.C.S., Wan J.M.F., Yang D. and Hyde K.D., Immunomodulatory compounds from Pestalotiopsis leucothës, an endophytic fungus from Tripterygium wilfordii, Life Sciences. 2005, 78: 147-156.

 

Kwong Y.L., Lau W.C.S., Ho S.L., Epstein R., Young R.T.T., Chan H.H.L., Tse H.F., Lam L., Chen W.H., Lee K.L.F., Ip M.S.M., Tsang K.W.T., Lam B., Tang S.C.W., Chan R.H.W., Lee S.W.L., Tan K.C.B., Yeung C.K., Chan D.T.M., Wong R.W.S., Choy C.B.Y., Wong B.C.Y., Li F.K., Lo W.K., Lui S.L., Cheung R.T.F., Mak W., Ho J.C.M., Mok T.M.Y., Kung A.W.C., Cheung B.M.Y., Chow W.S., Yuen R.M.F. and Wat N.M.S., In: Lau CP, Kumana CR, Lai CL, Lai KN, Lam KSL, Lam WK, Problem-Based Medical Case Management. Hong Kong, Hong Kong University Press, 2005.

 

Mok T.M.Y., Wong S.Y., Chan D.T.M., Tang W.M., Wong R.W.S. and Lau W.C.S., Necrotising Fasciitis in Rheumatic Diseases, Lupus. 2006, 15: 380-3.

 

Ng M.W., Lau W.C.S., Chan D.T.M., Wong W.H.S. and Lau Y.L., Polymorphisms of the toll-like receptor 9 (TLR9) gene with systemic lupus erythematosus in Chinese., Rheumatology. 2005, 44(11): 1456-1457.

 

Researcher : Lau YK



List of Research Outputs

 

Chan O.O., Jim M.H., Lam K.F., Siu D.C.W., Tong S.M., Ng F.H., Hui W.M., Chan C.K., Lai K.C., Hu H.C., Yuen R.M.F., Lau Y.K., Lee S.W.L., Lam S.K. and Wong B.C.Y., Patients with Coronary Artery Disease are at High Risk for Developing Colorectal Cancer and Adenoma: An Interim Analysis of a Prospective Study, Gastroenterology. 2006, 130 (4 Supp 2): A-36.

 

Chen W.H., Kaul U., Leung S.K., Lau Y.K., Tan H.C., Leung A.W., Lee M.K., Li S.K., Ng W., Lee P.Y., Lam K.F., Tse H.F. and Lau C.P., A randomized, double-blind, placebo-controlled trial of abciximab for prevention of in-stent restenosis in diabetic patients after coronary stenting: results of the ASIAD (Abciximab in Stenting Inhibitis restenosis Among Diabetics) Trial, J Invasive Cardiol. 2005, 17(10): 534-8.

 

Researcher : Lauder IJ



List of Research Outputs

 

Cheung B.M.Y., Chau J., McGhee S.M., Lauder I.J., Lau C.P. and Kumana C.R., Cost-effectiveness of Statins for Coronary Heart Disease Patients with Hypercholesterolaemia, Hong Kong Medical Journal. China, Scientific Communications International, Ltd., 2006, 12(2) Supplement: 20-23.

 

Cheung B.M.Y., Cheung G.T.Y., Lauder I.J., Lau C.P. and Kumana C.R., Meta-analysis of Large Outcome Trials of Angiotensin Receptor Blockers in Hypertension, Journal of Human Hypertension. 2006, 20(1): 37-43.

 

Researcher : Law KW



List of Research Outputs

 

Mak J.C.W., Leung C.M., Ho S.P., Law K.W., Ho A.S.S., Lam W.K., Ip M.S.M. and Chan M.M.W., Analysis of transforming growth factor-beta(1) gene polymorphisms in Hong Kong Chinese asthmatic patients, Journal of Allergy and Clinical Immunology. 2006, 117: 92-96.

 

Mak J.C.W., Leung C.M., Ho S.P., Law K.W., Tsang K.W.T., Lam W.K., Ip M.S.M. and Chan M.M.W., Best Poster - Genetic Susceptibility Of Transforming Growth Factor-beta1 Common Polymorphisms To Chinese Patients With Asthma, Hong Kong Allergy Convention 2005 . 2005.

 

Mak J.C.W., Leung C.M., Ho S.P., Law K.W., Tsang K.W.T., Lam W.K., Ip M.S.M. and Chan M.M.W., Genetic susceptibility of transforming growth factor-beta(1) common polymorphisms to Chinese patients with asthma, Hong Kong Allergy Convention, Hong Kong. 2005, Abstract AB25: p.54.

 

Mak J.C.W., Ho J.C.M., Ho S.P., Leung C.M., Law K.W., Lam W.K., Ip M.S.M. and Chan M.M.W., Polymorphisms in superoxide dismutase (SOD) and catalase genes - functional study in Chinese patients with asthma, Hong Kong Allergy Convention, Hong Kong. 2005, Abstract AB26: p.54.

 

Researcher : Lee KLF



List of Research Outputs

 

Kwong Y.L., Lau W.C.S., Ho S.L., Epstein R., Young R.T.T., Chan H.H.L., Tse H.F., Lam L., Chen W.H., Lee K.L.F., Ip M.S.M., Tsang K.W.T., Lam B., Tang S.C.W., Chan R.H.W., Lee S.W.L., Tan K.C.B., Yeung C.K., Chan D.T.M., Wong R.W.S., Choy C.B.Y., Wong B.C.Y., Li F.K., Lo W.K., Lui S.L., Cheung R.T.F., Mak W., Ho J.C.M., Mok T.M.Y., Kung A.W.C., Cheung B.M.Y., Chow W.S., Yuen R.M.F. and Wat N.M.S., In: Lau CP, Kumana CR, Lai CL, Lai KN, Lam KSL, Lam WK, Problem-Based Medical Case Management. Hong Kong, Hong Kong University Press, 2005.

 

Lau C.P., Lee K.L.F., Tse H.F., Echt D., Heaven D., Smith W. and Hood A., First Acute demonstration leadless pacing in patients using acoustic energy, Heart Rhythm. 2006, 3: S102.

 

Lau C.P., Lee K.L.F., Tse H.F., Echt D., Heaven D., Smith W. and Hood M., First acute demonstration of leadless pacing in patients using acoustic energy, Europace. 2006, 3/5.

 

Lee K.L.F., Tse H.F., Mullen T.J., Burnes J.E. and Lau C.P., LV pacing before intrinsic RV conduction results in improved RV hemodynamics, Europace. 2006, 18P/21.

 

Tse H.F., Lee K.L.F., Wan S.H., Yu Y., Walter H., Pastore J., Zhu Q., Kenknight B., Spinelli J. and Lau C.P., Area of left ventricular regional conduction delay and preserved myocardium predict response to cardiac resynchronization therapy., J Cardiovasc Electrophysiol. 2005, 16: 690-5.

 

Tse H.F., Siu C.W.D., Lee K.L.F., Fan K., Chan H., Tang M.O., Tsang V.Y.C., Lee S.W.L. and Lau C.P., The incremental benefit of rate-adaptive pacing on exercise performance during cardiac resynchronization therapy., J Am Coll Cardiol . 2005, 46(12): 2292-7.

 

Yiu K.H., Siu C.W.D., Lee K.L.F., Lam L., Chan R.H.W., Lee S.W.L., Lau C.P. and Tse H.F., Adverse Clinical Outcomes in Left-sided Infective Endocarditis Complicated Intravenous drug addict, JACC . 2006, 47: 281A.

 

Yiu K.H., Lau C.P., Lee K.L.F. and Tse H.F., Emerging energy sources for catheter ablation of atrial fibrillation, J Cardiovasc Electrophysiol. 2006, 17: S56-61.

 

Yiu K.H., Miu R., Lee K.L.F., Yung L.Y., Siu C.W.D., Tse H.F., Lam B., Lam J., Ip M.S.M. and Lau C.P., Improvement of sleep Apnea in heart failure patients after cardiac resynchronization therapy is associated with a significant dop in pulmonary arterial pressure, Heart Rhythm. 2006, 3, No. 5: S87.

 

Yiu K.H., Lee K.L.F., Tse H.F., Siu C.W.D., Lam B., Ip M.S.M. and Lau C.P., Improvement of sleep apnea in heart failure patients after cardiac resynchronization therapy is caused by relief of pulmonary congestion as reflected by a drop of pulmonary arterial pressure, Europace. 2006, 10/6.

 

Yiu K.H., Miu K.M., Lee K.L.F., Tse H.F., Siu C.W.D., Lam K., Lam B., Ip M.S.M. and Lau C.P., Improvement of sleep apnea in heart failure patients after cardiac resynchronization therapy is caused by relief of pulmonary congestion sa reflected by a drop of pulmonary congestion as reflected by a drop of pulmonary arterial pressure, Europace . 2006, 8 Supplement 1: 10/6.

 

Yiu K.H., Siu C.W.D., Lee K.L.F., Lam L., Chan R.H.W., Lee S.W.L., Lau C.P. and Tse H.F., Temporal Trend of Infective Endocarditis in Chinese: A Population Based Study Over 10 Years Period, JACC. 2006, 984-24.

 

Researcher : Lee SWL



List of Research Outputs

 

Chan O.O., Jim M.H., Lam K.F., Siu D.C.W., Tong S.M., Ng F.H., Hui W.M., Chan C.K., Lai K.C., Hu H.C., Yuen R.M.F., Lau Y.K., Lee S.W.L., Lam S.K. and Wong B.C.Y., Patients with Coronary Artery Disease are at High Risk for Developing Colorectal Cancer and Adenoma: An Interim Analysis of a Prospective Study, Gastroenterology. 2006, 130 (4 Supp 2): A-36.

 

Kwong Y.L., Lau W.C.S., Ho S.L., Epstein R., Young R.T.T., Chan H.H.L., Tse H.F., Lam L., Chen W.H., Lee K.L.F., Ip M.S.M., Tsang K.W.T., Lam B., Tang S.C.W., Chan R.H.W., Lee S.W.L., Tan K.C.B., Yeung C.K., Chan D.T.M., Wong R.W.S., Choy C.B.Y., Wong B.C.Y., Li F.K., Lo W.K., Lui S.L., Cheung R.T.F., Mak W., Ho J.C.M., Mok T.M.Y., Kung A.W.C., Cheung B.M.Y., Chow W.S., Yuen R.M.F. and Wat N.M.S., In: Lau CP, Kumana CR, Lai CL, Lai KN, Lam KSL, Lam WK, Problem-Based Medical Case Management. Hong Kong, Hong Kong University Press, 2005.

 

Lau E.O.Y., Tse H.F., Chan R.H.W., Chen W.H., Lee P.Y., Lee S.W.L., Chwang A.T.Y. and Lau C.P., Prediction of aortic augmentation index using radial pulse transmission-wave analysis, Journal of Hypertension. Lippincott Williams & Wilkins, 2006, 24(4): 723-730.

 

Tse H.F., Siu C.W.D., Lee K.L.F., Fan K., Chan H., Tang M.O., Tsang V.Y.C., Lee S.W.L. and Lau C.P., The incremental benefit of rate-adaptive pacing on exercise performance during cardiac resynchronization therapy., J Am Coll Cardiol . 2005, 46(12): 2292-7.

 

Yiu K.H., Siu C.W.D., Lee K.L.F., Lam L., Chan R.H.W., Lee S.W.L., Lau C.P. and Tse H.F., Adverse Clinical Outcomes in Left-sided Infective Endocarditis Complicated Intravenous drug addict, JACC . 2006, 47: 281A.

 

Yiu K.H., Siu C.W.D., Lee K.L.F., Lam L., Chan R.H.W., Lee S.W.L., Lau C.P. and Tse H.F., Temporal Trend of Infective Endocarditis in Chinese: A Population Based Study Over 10 Years Period, JACC. 2006, 984-24.

 

Researcher : Lee YYC



List of Research Outputs

 

Yung S.S.Y., Lee Y.Y.C., Zhang Q., Leung J.K.H., Lau S.K., Tsang R.C.W. and Chan D.T.M., Elevated glucose concentrations induce thrombospondin-1 synthesis in proximal renal tubular epithelial cells thereby stimulating fibronectin synthesis through TGF-b1 dependent and TGF-b1 independent pathways, Nephrology Dialysis Transplantation. 2006, 21: 1504-1513.

 

Yung S.S.Y., Lee Y.Y.C., Zhang Q., Tsang R.C.W. and Chan D.T.M., Thrombospondin-1 Induced by High Glucose Concentration Mediates Fibronectin Synthesis in Proximal Renal Tubular Epithelial Cells Through Both TGF-beta1 Dependent and TGF-beta1 Independent Pathways, Journal of the American Society of Nephrology. 2005, 16: 662A.

 

Researcher : Leung AYH



Project Title:

Ex-vivo expansion of haematopoietic stem cells derived from human umbilical blood with special reference to the effects of all-trans retinoic acid (ATRA)

Investigator(s):

Leung AYH, Liang RHS

Department:

Medicine

Source(s) of Funding:

Small Project Funding

Start Date:

11/2003

Completion Date:

02/2007

 

Abstract:

To investigate if ATRA can stimulate expansion of primitive HSC in-vitro, characterized by an increase in scid repopulation; to see if the effects of ATRA are dependent on the presence of stromal feeders; to study the molecular mechnaisms underlying the effects of ATRA on haematopoietic stem/progenitor cells.

 

Project Title:

A study of normal and deregulated haematopoiesis in zebrafish, with special reference to the role of BMP signaling in haematopoietic stem cell proliferation

Investigator(s):

Leung AYH, Liang RHS, Kung H

Department:

Medicine

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

07/2004

 

Abstract:

To characterize the cellular features of expanded haematopoietic cells, i.e. do they contain HSC or lineage-committed progenitors or do they contain both? to understand the key signal(s) that drive(s) haematopoietic cell proliferation in the developing embryos in relation to a heightened BMP signaling due to reduced antagonism by chordin.

 

Project Title:

Function of survivin during embryonichemoatopoiesis and vascular formation in a zebrafish model

Investigator(s):

Leung AYH

Department:

Medicine

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

Completion Date:

10/2006

 

Abstract:

To characterize the spatial and temporal expression of survivin in normal zebrafish embryos: is survivin expressed exclusively in hematopoietic or vascular tissues or is it expressed in both tissues? To investigate the effects of survivin knock-down in wild-type zebrafish embryos using anti-sense morpholino and dominant negative survivin mRNA injection: what would be the effect(s) on primitive hematopoiesis, vasculogenesis and angiogenesis?

 

Project Title:

A study of normal and deregulated haematopoiesis in zebrafish, with special reference to the role of BMP signaling in haematopoietic stem cell proliferation

Investigator(s):

Leung AYH

Department:

Medicine

Source(s) of Funding:

Merit Award for RGC CERG Funded Projects

Start Date:

01/2005

 

Abstract:

N/A

 

Project Title:

Function of survivin during embryonic angiogenesis and haematopoiesis in a zebrafish model

Investigator(s):

Leung AYH

Department:

Medicine

Source(s) of Funding:

Incentive Award for RGC CERG Fundable But Not Funded Projects

Start Date:

07/2005

Completion Date:

06/2006

 

Abstract:

N/A

 

List of Research Outputs

 

Hui C.K., Lie A.K.W., Au W.Y., Leung A.Y.H., Ma S.Y., Cheung W.W., Zhang H., Chim J.C.S., Kwong Y.L., Liang R.H.S. and Lau G., A long-term follow-up study on hepatitis B surface antigen-positive patients undergoing allogeneic hematopoietic stem cell transplantation, Blood. 2005, 106(2): 464-9.

 

Hui C.K., Cheung W.W., Zhang H., Au W.Y., Yueng Y.H., Leung A.Y.H., Leung N., Luk J.M.C., Lie A.K.W., Kwong Y.L., Liang R.H.S. and Lau G., Kinetics and risk of de novo hepatitis B infection in HBsAg negative patients undergoing cytotoxic chemotherapy, Gastroenterology. 2006, 131: 59-68.

 

Hui C.K., Cheung W.W., Zhang H., Au W.Y., Yueng Y.H., Leung A.Y.H., Leung N., Luk J.M.C., Lie A.K.W., Kwong Y.L., Liang R.H.S. and Lau G., Rituximab increases the Risk of De Novo hepatitis B infection in Hepatitis B Surface Antigen Negative Patients Undergoing Cytotoxic Chemotherapy, J Gastroenterol and Hepatol. 2006, 21(2): A73.

 

Kwan T.F., Liang R.H.S., Verfaillie C.M., Ekker S.C., Chan L.C., Lin S. and Leung A.Y.H., Regulation of primitive hematopoiesis in zebrafish embryos by the death receptor gene, Experimental Hematology . 2006, 34(1): 27-34.

 

Leung A.Y.H., Haematopoietic stem cell transplantation from Biology to the Clinics , Hong Kong International Cancer Congress . 2005.

 

Leung A.Y.H., Yuen K.Y. and Kwong Y.L., Polyma BK virus and haemorrhagic cystitis in haematopoietic stem cell transplantation - a changing paradigm, Bone Marrow Transplantation. 2005.

 

Leung A.Y.H., Yuen K.Y. and Kwong Y.L., Polyoma BK virus and haemorrhagic cystitis in haematopoietic stem cell transplantation: a changing paradigm, Bone Marrow Transplantation. 2005, 36(11): 929-37.

 

Leung A.Y.H., Leung J.C.K., Chan Y.Y., Ma E.S.K., Kwan T.F., Lai K.N., Meng A. and Liang R.H.S., Proliferating cell nuclear antigen (PCNA) as a proliferative marker during embryonic and adult zebrafish hematopoiesis, Histochemistry and Cell Biology. 2005, 124(2): 105-11.

 

Leung A.Y.H., Wong A.S.Y., Chan G.C.F., Yuen K.Y. and Kwong Y.L., Urinary reactivation of polyoma BK virus but not adenovirus in paediatric and adolescent patients after haematopoietic stem cell transplantation, Bone Marrow Transplantation. 2006, 37(6): 621-3.

 

Leung A.Y.H., Viral reactivation after haematopoietic stem cell transplantation – the BKV paradigm, 10th Hong Kong Medical Forum 2005. 2005.

 

Researcher : Leung CM



List of Research Outputs

 

Mak J.C.W., Leung C.M., Ho S.P., Law K.W., Ho A.S.S., Lam W.K., Ip M.S.M. and Chan M.M.W., Analysis of transforming growth factor-beta(1) gene polymorphisms in Hong Kong Chinese asthmatic patients, Journal of Allergy and Clinical Immunology. 2006, 117: 92-96.

 

Mak J.C.W., Leung C.M., Ho S.P., Law K.W., Tsang K.W.T., Lam W.K., Ip M.S.M. and Chan M.M.W., Best Poster - Genetic Susceptibility Of Transforming Growth Factor-beta1 Common Polymorphisms To Chinese Patients With Asthma, Hong Kong Allergy Convention 2005 . 2005.

 

Mak J.C.W., Leung C.M., Ho S.P., Law K.W., Tsang K.W.T., Lam W.K., Ip M.S.M. and Chan M.M.W., Genetic susceptibility of transforming growth factor-beta(1) common polymorphisms to Chinese patients with asthma, Hong Kong Allergy Convention, Hong Kong. 2005, Abstract AB25: p.54.

 

Mak J.C.W., Ho S.P., Leung C.M., Lam W.K., Ip M.S.M. and Chan M.M.W., Genetic susceptibility to chronic obstructive pulmonary disease (COPD) : Transforming growth factor-beta common polymorphisms and plasma levels, American Journal of Respiratory and Critical Care Medicine. 2006, 173(3): A624.

 

Mak J.C.W., Ho S.P., Leung C.M., Lam W.K., Ip M.S.M. and Chan M.M.W., Genetic susceptibility to chronic obstructive pulmonary disease (COPD) : transforming growth factor-beta(1) common polymorphisms and plasma levels, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong, January 2006. Abstract Book 089: pp.56.

 

Mak J.C.W., Leung C.M., Ho S.P., Ko F.W.S., Cheung A.H.K., Ip M.S.M. and Chan M.M.W., Polymorphisms in manganese superoxide dismutase and catalase genes - functional study in Hong Kong Chinese asthma patients , Clinical and Experimental Allergy. 2006, 36: 440-447.

 

Mak J.C.W., Ho J.C.M., Ho S.P., Leung C.M., Law K.W., Lam W.K., Ip M.S.M. and Chan M.M.W., Polymorphisms in superoxide dismutase (SOD) and catalase genes - functional study in Chinese patients with asthma, Hong Kong Allergy Convention, Hong Kong. 2005, Abstract AB26: p.54.

 

Researcher : Leung JCK



Project Title:

The roles of electrical charge of IgA1 in the pathogenesis of IgA nephropathy

Investigator(s):

Leung JCK, Lai KN

Department:

Medicine

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

09/2003

Completion Date:

08/2005

 

Abstract:

To characterize the glycosylation profile, size and possible components of IgA(1) molecules bearing different charges isolated from IgAN patients; to investigate the role of leucocytes and hepatocytes in the handling and metabolism of different charges of IgA(1) in IgAN; to explore the pathophysiologic effects of different charges of IgA(1) from IgAN patients on human mesangial cells.

 

Project Title:

The roles of electrical charge of IgA1 in the pathogenesis of IgA nephropathy

Investigator(s):

Leung JCK, Lai KN

Department:

Medicine

Source(s) of Funding:

Merit Award for RGC CERG Funded Projects

Start Date:

09/2003

Completion Date:

08/2005

 

Abstract:

N/A

 

Project Title:

Peritoneal membrane dysfunction in continuous ambulatory peritoneal dialysis (CAPD): the role of connective tissue growth factor (CTGF)

Investigator(s):

Leung JCK

Department:

Medicine

Source(s) of Funding:

Merit Award for RGC CERG Funded Projects

Start Date:

01/2005

 

Abstract:

N/A

 

Project Title:

Peritoneal membrane dysfunction in continuous ambulatory peritoneal dialysis (CAPD): the role of connective tissue growth factor (CTGF)

Investigator(s):

Leung JCK, Li FK, Lai KN

Department:

Medicine

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

01/2005

 

Abstract:

To examine the pathophysiological effects of PDFs and their components on peritoneal cells; to understand the mechanism of CTGF expression and its regulation in peritoneal cells; to explore the feasibility of treating peritoneal membrane dysfunction by blocking CTGF.

 

Project Title:

Is there a reno-protective role of bone morphogenetic protein-7 in IgA nephropathy?

Investigator(s):

Leung JCK

Department:

Medicine

Source(s) of Funding:

Merit Award for RGC CERG Funded Projects

Start Date:

01/2006

 

Abstract:

N/A

 

Project Title:

Is there a reno-protective role of bone morphogenetic protein-7 in IgA nephropathy?

Investigator(s):

Leung JCK, Lai KN

Department:

Medicine

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

01/2006

 

Abstract:

To examine the renal expression and regulation of BMP-7 and its receptors in human IgAN; to explore the mechanism of BMP-7 in protecting and reversing pIgA-induced renal injury in IgAN.

 

Project Title:

The role of leptin on peritoneal mesothelial cell under high glucose

Investigator(s):

Leung JCK, Lai KN

Department:

Medicine

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

03/2006

 

Abstract:

Continuous ambulatory peritoneal dialysis (CAPD) is an important treatment modality of the renal replacement therapy. Unfortunately, the peritoneal membrane frequently exhibits structural and functional changes following long-term dialysis [1]. During CAPD, peritoneal cells are repeatedly exposed to a non-physiological hypertonic environment that may lead to peritoneal fibrosis and, ultimately, ultrafiltration failure [2]. Peritoneal adipocytes, previously regarded as of less importance in peritoneal physiology during CAPD, are ubiquitously found in peritoneal tissues. Contrary to the prevailing view that adipose tissues merely function as energy storage depot, there is now compelling evidence suggesting adipocytes can mediate various physiologic processes through secretion of an array of adipokines including leptin, adiponectin, resistin, tumour necrosis factor-alpha (TNF-alpha), interleukin (IL)-6, transforming growth factor-beta (TGF-beta), tissue factors and other growth factors [3, 4]. Adipocytes also express receptors for leptin, insulin growth factor-1 (IGF-1), TNF-alpha, IL-6, TGF-beta that orchestrate a network of autocrine, paracrine and endocrine signals [4]. In parietal peritoneum, adipocytes lie deep underneath the mesothelium and connective tissue. During the fluid dwell in CAPD, solutes in peritoneal dialysis fluid (PDF) are transported by passive diffusion through the peritoneal barrier and come into contact with the adipocytes. In the omentum, adipocytes are in close contact with mesothelial cells. Ultrastructural study reveals that a portion of adipocytes are protruded from the mesothelial surface suggesting that omental adipocytes may be directly exposed to dialysate [5]. In addition, dialysate can also reach the parietal adipose tissue when there is junctional damage or denudation of the mesothelial monolayer. It is therefore logical to postulate that under repeated exposure to PDF and the continuous changes of the physiologic milieu of the peritoneal cavity during CAPD, peritoneal adipocytes will inevitably be "activated". Yet, study on any impact of CAPD on peritoneal adipocytes is scarce. Leptin, an adipocytes-derived 16-kDa hormone, exerts many biological effects through leptin receptor including regulation of food intake, modification of insulin action, induction of angiogenesis and modulation of the immune system [4, 6]. Leptin receptors belong to the class I cytokine family with six spliced isoforms (Ob-Ra to Ob-Rf) [4]. Only the full-length isoform, Ob-Rb, contains the intracellular motifs essential for the Janus kinase-signal transducers and activation (JAK-STAT) signal transduction pathway [4, 7]. Accumulating evidence for systemic effects of leptin on specific tissues and metabolic pathways indicates that leptin operates both directly and indirectly to orchestrate complex pathophysiological processes [6, 8]. Leptin is cleared principally by the kidney and the serum leptin concentration is increased in patients with chronic renal failure or undergoing dialysis [9]. Marked increase in leptin concentration in serum as well as spent peritoneal dialysate has been reported following CAPD treatment [10]. It is now clear that leptin in peritoneal dialysate is derived not only from plasma but also locally from peritoneal adipose tissue. In vitro experiments using murine adipocyte cell line 3T3-L1 showed glucose-based PDFs induce a higher leptin secretion [11]. The present proposal was designed to determine whether functional leptin receptor is expressed by human peritoneal mesothelial cells (HPMC) and if so, the possible implication in CAPD. We set out to determine whether functional leptin receptors are expressed by HPMC and if so, whether these mesothelial leptin receptors could be triggered by leptin to modulate local TGF-beta production. We hypothesize that: a) Exposure of the peritoneum to PDF and its components will increase leptin synthesis by peritoneal adipocytes. b) Leptin, once released from adipocytes, will act on specific leptin receptors on mesothelial cells or adipocytes and trigger TGF-beta production by means of a specific signal transduction pathway. Specific aims: (i) To examine the pathophysiological effects of glucose on leptin synthesis by peritoneal adipocytes. (ii) To understand the mechanism of leptin regulation and its signaling pathways in peritoneal adipocytes under high glucose. References 1. Di Paolo N, Sacchi G, De Mia M, Gaggiotti E, Capotondo L, Rossi P, Bernini M, Pucci AM, Ibba L, Sabatelli P, et al.: Morphology of the peritoneal membrane during continuous ambulatory peritoneal dialysis. Nephron 44:204-211, 1986 2. Rubin J, Herrera GA, Collins D: An autopsy study of the peritoneal cavity from patients on continuous ambulatory peritoneal dialysis. Am J Kidney Dis 18:97-102, 1991 3. Friedman JM: Obesity in the new millennium. Nature 404:632-634, 2000 4. Myers MG, Jr.: Leptin receptor signaling and the regulation of mammalian physiology. Recent Prog Horm Res 59:287-304, 2004 5. Di Paolo N, Sacchi G: Atlas of peritoneal histology. Perit Dial Int 20 Suppl 3:S5-96, 2000 6. Pond CM: Adipose tissue and the immune system. Prostaglandins Leukot Essent Fatty Acids 73:17-30, 2005 7. Ahima RS, Osei SY: Leptin signaling. Physiol Behav 81:223-241, 2004 8. Fruhbeck G, Gomez-Ambrosi J, Muruzabal FJ, Burrell MA: The adipocyte: a model for integration of endocrine and metabolic signaling in energy metabolism regulation. Am J Physiol Endocrinol Metab 280:E827-847, 2001 9. Wolf G, Chen S, Han DC, Ziyadeh FN: Leptin and renal disease. Am J Kidney Dis 39:1-11, 2002 10. Tsujimoto Y, Shoji T, Tabata T, Morita A, Emoto M, Nishizawa Y, Morii H: Leptin in peritoneal dialysate from continuous ambulatory peritoneal dialysis patients. Am J Kidney Dis 34:832-838, 1999 11. Teta D, Tedjani A, Burnier M, Bevington A, Brown J, Harris K: Glucose-containing peritoneal dialysis fluids regulate leptin secretion from 3T3-L1 adipocytes. Nephrol Dial Transplant 20:1329-1335, 2005

 

List of Research Outputs

 

Chan L.Y., Leung J.C.K., Tang S.C.W. and Lai K.N., Glucose modulates leptin and adiponectin synthesis by human peritoneal omental adipocyte, Journal of American Society of Nephrology. 2005, 16: 791A.

 

Chan L.Y., Leung J.C.K., Tang S.C.W., Choy C.B.Y. and Lai K.N., Tubular expression of angiotensin II receptors and their regulation in IgA nephropathy, Journal of American Society of Nephrology. 2005, 16(8): 2306-2317.

 

Guo H., Leung J.C.K., Chan L.Y., Lui S.L., Tsang W.L. and Lai K.N., Modulation of intra-pulmonary TGF-beta expression by mycophenolate mofetil in lupus prone MRL/lpr mice, Lupus. 2005, 14(8): 583-592.

 

Lai K.N., Chan L.Y., Tang S.C.W. and Leung J.C.K., Ganoderma extract prevents albumin-induced oxidative damage and chemokines synthesis in cultured human proximal tubular epithelial cells, Nephrology Dialysis Transplantation. 2006, 21(5): 1188-1197.

 

Lai K.N., Tang S.C.W., Chan L.Y. and Leung J.C.K., Monocytes/T cells modulate chemokine release and chemokine receptor expression in proximal tubular epithelial cells in proteinuric state, Journal of American Society of Nephrology. 2005, 16: 642A.

 

Lam M.F., Leung J.C.K., Lo W.K., Lui S.L., Chan D.T.M. and Lai K.N., Increased serum leptin levels during peritoneal dialysis related peritonitis associated with prolonged inflammation and loss of lean body mass, Journal of American Society of Nephrology. 2005, 16: 713A.

 

Lam M.F., Leung J.C.K., Tang C.S.O., Lo W.K., Tse K.C., Yip T.P.S., Lui S.L., Chan D.T.M. and Lai K.N., Mannose binding lectin level and polymorphism in patients on long-term peritoneal dialysis, Nephrology Dialysis Transplantation. 2005, 20: 2489-2496.

 

Leung A.Y.H., Leung J.C.K., Chan Y.Y., Ma E.S.K., Kwan T.F., Lai K.N., Meng A. and Liang R.H.S., Proliferating cell nuclear antigen (PCNA) as a proliferative marker during embryonic and adult zebrafish hematopoiesis, Histochemistry and Cell Biology. 2005, 124(2): 105-11.

 

Leung J.C.K., Chan L.Y., Li F.K., Tang S.C.W., Chan K.W., Chan D.T.M., Lam M.F., Wieslander A. and Lai K.N., Glucose degradation products downregulate ZO-1 expression in human peritoneal mesothelial cells: the role of VEGF, Nephrology Dialysis Transplantation. 2005, 20(7): 1336-1349.

 

Leung J.C.K., Chan L.Y., Tang S.C.W. and Lai K.N., Glycosylation profile of anionic polymeric IgA and their binding characteristics to cultured mesangial cells in IgA nephropathy, Journal of American Society of Nephrology. 2005, 16: 49A.

 

Leung J.C.K., Chan Y.Y., Tang S.C.W., Chu K.M. and Lai K.N., Leptin induces TGF-b synthesis through functional leptin receptor expressed by human peritoneal meoshtelial cell, Kidney International. 2006, 69: 2078-2086.

 

Tang S., Lai F.M., Lui R.Y.H., Tang C.S.O., Kung N.N.S., Ho Y.W., Chan K.W., Leung J.C.K. and Lai K.N., Lamivudine in hepatitis B-associated membranous nephropathy, Joint symposium on extracorporeal support for multi-organ failure organized by Hong Kong College of Physicians Scientific Symposium and Hong Kong Society of Nephrology Annual Scientific Meeting, 10-11 September 2005, Hong Kong. 2005.

 

Tang S.C.W., Leung J.C.K., Chan L.Y., Tsang W.L. and Lai K.N., Activation of tubular epithelial cells in diabetic nephropathy and the role of the peroxisome proliferator-activated receptor-gamma agonist, Journal of American Society of Nephrology. 2006, 17(6): 1633-1643.

 

Tang S.C.W., Lai F.M., Lui Y.H., Tang C.S.O., Kung N.N., Ho Y.W., Chan K.W., Leung J.C.K. and Lai K.N., Lamivudine in hepatitis B-associated membranous nephropathy, Kidney International. 2005, 68(4): 1750-1758.

 

Tang S.C.W., Leung J.C.K., Chan L.Y., Lui Y.H., Tang C.S.O., Kan C.H., Ho Y.W. and Lai K.N., Mycophenolate mofetil alleviates persistent proteinuria in IgA nephropathy, Kidney International. 2005, 68(2): 802-812.

 

Tang S.C.W., Ho Y.W., Leung J.C.K. and Lai K.N., Mycophenolate mofetil in the treatment of steroid-resistant primary focal segmental glomerulosclerosis, Journal of Nephrology. 2005, 18(4): 429-432.

 

Tang S.C.W., Leung J.C.K., Chan L.Y., Tsang W.L. and Lai K.N., Role of PPAR-g agonist in diabetic nephropathy: An in vivo study, Journal of American Society of Nephrology. 2005, 16: 613A.

 

Xia Y., Li Y., Du Y., Yang N., Li C., Leung J.C.K., Lam M.F., Huang W., Chen S., Maxwell P.H., Lai K.N. and Wang Y.M., Association of MEGSIN 2093C-2180T haplotype at the 3' untranslated region with disease severity and progression of IgA nephropathy, Nephrology Dialysis Transplantation. 2006, 21(6): 1570-1574.

 

Zhong Q., Leung J.C.K., Chan L.Y., Tsang W.L., Chen X. and Lai K.N., The study of Chinese medicinal herbal formula Shen San Fang in the treatment of experimental IgA nephropathy, the American Journal Of Chinese Medicine. 2005, 33(4): 613-626.

 

Researcher : Leung JKH



List of Research Outputs

 

Yung S.S.Y., Tsang R.C.W., Sun Y., Leung J.K.H. and Chan D.T.M., Effect of Human Anti-DNA Antibodies on Proximal Renal Tubular Epithelial Cell Cytokine Expression: Implication on Tubulointerstitial Inflammation in Lupus Nephritis, Journal of the American Society of Nephrology. 2005, 16: 3281-3294.

 

Yung S.S.Y., Lee Y.Y.C., Zhang Q., Leung J.K.H., Lau S.K., Tsang R.C.W. and Chan D.T.M., Elevated glucose concentrations induce thrombospondin-1 synthesis in proximal renal tubular epithelial cells thereby stimulating fibronectin synthesis through TGF-b1 dependent and TGF-b1 independent pathways, Nephrology Dialysis Transplantation. 2006, 21: 1504-1513.

 

Yung S.S.Y., Tsang R.C.W., Leung J.K.H. and Chan D.T.M., Increased mesangial cell hyaluronan expression during active lupus nephritis is mediated by anti-DNA antibody-induced IL-1beta, Kidney International. 2006, 69(2): 272-280.

 

Researcher : Leung SK



List of Research Outputs

 

Chen W.H., Kaul U., Leung S.K., Lau Y.K., Tan H.C., Leung A.W., Lee M.K., Li S.K., Ng W., Lee P.Y., Lam K.F., Tse H.F. and Lau C.P., A randomized, double-blind, placebo-controlled trial of abciximab for prevention of in-stent restenosis in diabetic patients after coronary stenting: results of the ASIAD (Abciximab in Stenting Inhibitis restenosis Among Diabetics) Trial, J Invasive Cardiol. 2005, 17(10): 534-8.

 

Researcher : Leung SMH



List of Research Outputs

 

Chim J.C.S., Liang R.H.S., Leung S.M.H., Yip S.F. and Kwong Y.L., Aberrant gene promoter methylation marking disease progression in multiple myeloma, Leukemia. 2006, 20(6): 1190-2.

 

Researcher : Leung TWT



List of Research Outputs

 

Epstein R., Leung T.W.T. and Cheung P.S.Y., Panmucositis and chemosensitisation associated with betel quid chewing during dose-dense adjuvant breast cancer chemotherapy. Epub 2006 Mar 11. , Cancer Chemother Pharmacol. 2006, 58(6): 835-7.

 

Epstein R., Leung T.W.T., Mak J. and Cheung P.S.Y., Utility of a web-based breast cancer predictive algorithm for adjuvant chemotherapeutic decision making in a multidisciplinary oncology center. , Cancer Investigation. Taylor & Francis, 2006, 24(4): 367-373.

 

Researcher : Leung WCW



List of Research Outputs

 

Li Y., Leung W.C.W., Chen Y., Cheung B.M.Y., Liang R.Y.H., Yik P.Y., Hui K.C., Ng P.K.M., Mak W.W., Jin D. and Song Y., Association of the cholesterol 24S-hydroxylase polymorphism with Alzheimer's disease in Chinese, HUGO 2006 Helsinki, Finland, 31 May-03 June 2006 . 2006.

 

Li Y., Leung W.C.W., Chen Y., Cheung B.M.Y., Liang R.Y.H., Yik P.Y., Ng K.M., Mak W., Jin D., st. George-Hyslop P. and Song Y., Intron 2 (T/C) CYP46 polymorphism is associated with Alzheimer's disease in Chinese. , Dement Geriatr Cogn Disord. 2006, 22: 399-404.

 

Researcher : Leung WH



List of Research Outputs

 

Leung W.H., Tsang S.F. and Chim J.C.S., Extrapulmonary tuberculous abscess in chronic lymphocytic leukaemia (CLL) treated with fludarabine: Case report and review of literature, American Journal of Hematology. 2005, 79(3): 1437-45.

 

Researcher : Leung YH



List of Research Outputs

 

Kwok R.P., Sun J.Z., Tipoe G.L., Leung Y.H., Yan C.P.K., Ooi C.G.C., Ho P.L., Mak J.C.W., Lam W.K. and Tsang K.W.T., Pseudomonas aeruginosa pyocyanin : discruption of ultrastructure of human respiratory mucosa in vitro, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong,. 2006, Abstract Book 087: pp. 55.

 

Kwok R.P., Sun J.Z., Tipoe G.L., Leung Y.H., Yan C.P.K., Ooi C.G.C., Ho P.L., Mak J.C.W., Lam W.K. and Tsang K.W.T., Pseudomonas aeruginosa pyocyanin : discruption of ultrastructure of human respiratory mucosa in vitro, Respirology. 2005, 10 (Suppl): A126 (#170).

 

Kwok R.P., Leung Y.H., Sun J.Z., Yan C.P.K., Ooi C.G.C., Ho P.L., Tipoe G.L., Lam W.K. and Tsang K.W.T., The effects of gelomyrtol ForteÒ on human ciliary beat frequency in bronchiectasis subjects in vitro, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2006, Abstract Book 086: pp.54.

 

Kwok R.P., Leung Y.H., Sun J.Z., Yan C.P.K., Ooi C.G.C., Ho P.L., Tipoe G.L., Lam W.K. and Tsang K.W.T., The effects of gelomyrtol forteÒ on human ciliary beat frequency in bronchiectasis subjects in vitro, Respirology. 2005, 10 (Suppl): A126 (#169).

 

Kwok R.P., Leung Y.H., Sun J.Z., Yan C.P.K., Ko K.W., Ooi C.G.C., Ho P.L., Tipoe G.L., Lam W.K. and Tsang K.W.T., The effects of myrtol standardized on human ciliary beat frequency in vitro, European Respiratory Medicine. 2005, 26 (Suppl 49): 100S (#714).

 

Mak J.C.W., Ho S.P., Leung Y.H., Ho P.L., Ooi C.G.C., Tipoe G.L., Yan C.P.K., Ip M.S.M., Lam W.K. and Tsang K.W.T., Elevated levels of transforming growth factor-beta(1) in serum of patients with stable bronchiectasis, Respiratory Medicine. 2005, 99: 1223-1228.

 

Researcher : Li FK



List of Research Outputs

 

Kwong Y.L., Lau W.C.S., Ho S.L., Epstein R., Young R.T.T., Chan H.H.L., Tse H.F., Lam L., Chen W.H., Lee K.L.F., Ip M.S.M., Tsang K.W.T., Lam B., Tang S.C.W., Chan R.H.W., Lee S.W.L., Tan K.C.B., Yeung C.K., Chan D.T.M., Wong R.W.S., Choy C.B.Y., Wong B.C.Y., Li F.K., Lo W.K., Lui S.L., Cheung R.T.F., Mak W., Ho J.C.M., Mok T.M.Y., Kung A.W.C., Cheung B.M.Y., Chow W.S., Yuen R.M.F. and Wat N.M.S., In: Lau CP, Kumana CR, Lai CL, Lai KN, Lam KSL, Lam WK, Problem-Based Medical Case Management. Hong Kong, Hong Kong University Press, 2005.

 

Leung J.C.K., Chan L.Y., Li F.K., Tang S.C.W., Chan K.W., Chan D.T.M., Lam M.F., Wieslander A. and Lai K.N., Glucose degradation products downregulate ZO-1 expression in human peritoneal mesothelial cells: the role of VEGF, Nephrology Dialysis Transplantation. 2005, 20(7): 1336-1349.

 

Tse K.C., Tang S.C.W., Tang C.S.O., Lai K.N., Li F.K. and Chan D.T.M., Angiotensin inhibition or blockade for the treatment of patients with quiescent lupus nephritis and persistent proteinuria, Lupus. 2005, 14(12): 947-952.

 

Yip T.P.S., Tse K.C., Lam M.F., Tang S.C.W., Li F.K., Choy C.B.Y., Lui S.L., Chan D.T.M., Lai K.N. and Lo W.K., Risk factors and outcomes of extended-spectrum beta-lactamase-producing E. coli peritonitis in CAPD patients, Peritoneal Dialysis International. 2006, 26(2): 191-197.

 

Yung S.S.Y., Li F.K. and Chan D.T.M., Peritoneal mesothelial cell culture and biology, Peritoneal Dialysis International. 2006, 26(2): 162-173.

 

Researcher : Li G



Project Title:

The Neuroprotective Effect of Coenzyme Q10 in AD mice model

Investigator(s):

Li G, Yang ES, Yang YiHong, Jack Jr. Clifford

Department:

Medical Faculty

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

03/2006

 

Abstract:

Alzheimer's disease (AD) and ischemic cerebrovascular disease are two main causes of dementia in elderly people. Recent basic and clinical investigations demonstrate that AD and vascular dementia (VaD), traditionally considered two independent neurological disorders, may interact in an additive manner. In clinical studies, the presence of ischemic lesions enhances the cognitive deficits in patients with AD pathology. Mutations in the genes of beta-amyloid precursor protein (APP), presenilin 1 (PS1) and presenilin 2 (PS2) cause familial AD. In transgenic mice with overexpressed APP, susceptibility to ischemic brain damage caused by middle cerebral artery occlusion (MCAO) is increased. In AD patients, the extent of AD pathology is increased if ischemic stroke coexists. Elderly subjects are more likely to have been demented in life if both AD pathology and ischemic cerebrovascular disease are present at autopsy than if either is pathology is found in isolation. Several studies suggest a possible role of increased oxidative stress and impairment of mitochondrial energy metabolism in the pathogenesis of both AD and stroke. A number of investigators have identified a deficiency in the complex VI, cytochrome c oxidase (COX) of the mitochondrial electron transport chain in AD patients and a reduced activity of complexes I and III in ischemic conditions. Coenzyme Q10 (CoQ10) is an essential biological cofactor produced endogenously in the body and provided in the food chain. As the electron acceptor for mitochondrial complexes I and II, it has an essential role in cellular energy production as an electron and proton carrier. Complex I or II dysfunction are found in neurological disorders such as Parkinson’s disease and Huntington disease. Shults et al. reported a correlation between mitochondrial CoQ10 level and the biological activity of complexes I - IV Parkinson’s disease patients who were administered the highest dose of CoQ10 showed the greatest clinical benefit. Oral CoQ10 supplementation increases brain mitochondrial concentrations and exerts neuroprotective effects. A neuroprotective effect of CoQ10 has been found in various animal models of stroke and this has been attributed to its role as a potent antioxidant and an oxygen derived free radical scavenger. This finding has not been universally replicated, however, as Li and his colleagues found that immediate treatment with CoQ10 via intraperitoneal injection did not prevent neuronal injuries following global and focal ischemia. Mitochondrial abnormalities have been found in human AD patients, and there are a few reports about the therapeutic effect of CoQ10 in AD patients. Results have been mixed however, for example, de Bustos et al. investigated serum levels of CoQ10 in patients with AD and found no relationship with the risk of AD and vascular dementia. CoQ10 has been shown to have a neuroprotective effect in other neurodegenerative diseases, such as Parkinson’s and Huntington’s diseases. In this study, we address the effects of CoQ10 on AD and cerebral ischemia using volume magnetic resonance imaging (MRI) in transgenic animal models. APP/PS1, APP and PS1 transgenic mice with ischemic stroke will be treated with high-dose CoQ10 for 28 days, and then their brain specimens will be examined by MRI to investigate the neuroprotective effects of CoQ10, compared to the non-treated counterparts. Transgenic rather than wild type mice will be employed in order to amplify the destructive effects of stroke in the experimental animals.

 

List of Research Outputs

 

Li G., Xia H.H.X., Chen M., Gu Q., Wang J., Peng J., Chan O.O., Cho C.H., So H.L., Lam S.K., Hu P.J., Liang Y.J., Lin H., Berg D.E., Feng Z.H., Langenback R. and Wong B.C.Y., Effects of Cyclooxygenase-1 and -2 Gene Disruption on Helicobacter pylori-Induced Inflammation, Journal of Infectious Diseases. 2006, 193(7): 1037-1046.

 

Researcher : Li G



List of Research Outputs

 

Li G., Xia H.H.X., Chen M., Gu Q., Wang J., Peng J., Chan O.O., Cho C.H., So H.L., Lam S.K., Hu P.J., Liang Y.J., Lin H., Berg D.E., Feng Z.H., Langenback R. and Wong B.C.Y., Effects of Cyclooxygenase-1 and -2 Gene Disruption on Helicobacter pylori-Induced Inflammation, Journal of Infectious Diseases. 2006, 193(7): 1037-1046.

 

Researcher : Li GR



Project Title:

Volume-sensitive chloride current and cell volume regulation in human atrial myocytes

Investigator(s):

Li GR, Lau CP, Chiu SW, Tse HF

Department:

Medicine

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

12/2001

 

Abstract:

To determine the intracellular signaling pathways that regulate ICl.vol and cell volume in human atrium; to determine whether ICl.vol is persistently activated in atrial myocytes from patients with dilated atrial cardiomyopathy.

 

Project Title:

Ionic channels of mesenchymal stem cells from bone marrow and cell proliferation

Investigator(s):

Li GR, Lau CP, Chung SSM, Tse HF

Department:

Medicine

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

12/2003

Completion Date:

07/2006

 

Abstract:

To analyze the molecular identities of IKDR, IKCa, and INa in MSCs from rat bone marrow with semi-quantitative reverse transcript-polymeterase chain reaction (RT-PCR) and patch clamp techniques; to test the hypothesis that the three types of channels (IKDR, IKCa and INa) are involved in the proliferation of rat MSCs by determining cell proliferation in the absence and presence of channel blockers and modulators.

 

Project Title:

Ionic channels of mesenchymal stem cells from bone marrow and cell proliferation

Investigator(s):

Li GR, Lau CP, Chung SSM, Tse HF

Department:

Medicine

Source(s) of Funding:

Merit Award for RGC CERG Funded Projects

Start Date:

12/2003

Completion Date:

11/2005

 

Abstract:

N/A

 

Project Title:

Modulation of cloned human cardiac potassium channel by protein tyrosine kinase

Investigator(s):

Li GR

Department:

Medical Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

Completion Date:

10/2005

 

Abstract:

To clarify specific PTK pathway that is involved in the modulation of IKs channels.

 

Project Title:

Ion channels of preadipocytes and cell proliferation and differentiation

Investigator(s):

Li GR

Department:

Medical Faculty

Source(s) of Funding:

Incentive Award for RGC CERG Fundable But Not Funded Projects

Start Date:

07/2005

Completion Date:

06/2006

 

Abstract:

N/A

 

Project Title:

Studies on Ion Channels in Human Pre-adipocytes

Investigator(s):

Li GR, Lau CP

Department:

Medical Faculty

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

05/2006

 

Abstract:

Ion channels play an important role in the physiological activities of many types of cells. In excitable cells, activation of ion channels generates action potentials and participates in excitation-contraction (muscles), excitation-secretion (glands), and impulse conduction (nerve and muscles), as well as repolarizing cell membrane potential. In proliferative cells, ion channels are found to be required for cell proliferation. Recent studies have demonstrated that several K channels, eg. inward rectifier K channels (IKir), delayed rectifier K channels (IKDR), ATP-sensitive K channel (IKATP), are involved in the cell cycling of lymphocytes, neuronal glial cells (e.g. astrocytes), epithelial cells, and cancer cells. Blockade of IKDR is believed to inhibit cell proliferation, whereas inhibition of IKIR promotes proliferation in rat spinal cord astrocytes. In addition, volume-sensitive chloride current (ICl.vol) is involved in the proliferation of several types of cells including vascular smooth muscle and endothelial cells, cancer cells etc. These studies indicate an important relationship between ion channels and cell proliferation. There has been a dramatic increase in the incidence of obesity resulting from an excess of white adipose tissue. Obesity is a prevalent health hazard in industrial countries, and is closely associated with the occurrence of type 2 diabetes and cardiovascular disease. Preadipocytes are the origin of fat cells of white adipose tissue. For the past two decades, in vitro systems have been extensively used to study adipocyte differentiation with preadipocytes. Although significant progress has been made in the dissection of the molecular and cellular events taking place during the transition from undifferentiated preadipocytes into mature round fat cells, control of adipocyte differentiation is not completely understood, especially ion channels and thire physiological roles in proliferation/differentiation have not been studied. The present proposal was to study ion channel expression and thire molecular identidies in human pre-adipocytes commercially obtained from CellSicence using whole-cell patch clamp and RT-PCR techniques, and to provide the experimental data for obtaining external RGC grant to further study whether/how ion channels are involved in proliferation/differentiation in human pre-adipocytes.

 

List of Research Outputs

 

Dong M., Lau C.P., Gao Z., Tseng G.N. and Li G.R., Characterization of recombinant human cardiac KCNQ1/KCNE1 channels (I (Ks)) stably expressed in HEK 293 cells, In: 2006 Apr;Epub 2006 Aug 14., J Membr Biol.. 2006, 210: 183-192.

 

Loo T.Y., Jin L.J. and Li G.R., Detection of Bacteroides forsythus and Porphyromonas gingivalis from root canals, Journal of Dental Research. 2006, 85 (Spec Iss B): 297.

 

Wang K., Xue T., Tsang S.Y., Huizen R.V., Wong C.W., Lai K.W.H., Ye Z., Cheng L., Zhang J.C.L., Li G.R., Lau C.P., Tse H.F. and Li R.A., Electrophysiological Properties of Pluripotent Human and Mouse Embryonic Stem Cells, Stem Cells. 2005, 23: 1526-1534.

 

Researcher : Li LSW



List of Research Outputs

 

Cheung C.Y.C., Lee T.M.C., Yip J.T.H., King K.E. and Li L.S.W., The differential effects of thalamus and basal ganglia on facial emotion recognition, Brain and Cognition. 2006, 61: 262-268.

 

Luk J.K.H., Cheung R.T.F., Ho S.L. and Li L.S.W., Does age predict outcome in stroke rehabilitation? A study of 878 Chinese subjects, 4th World Congress for NeuroRehabilitation. 2006, 20: 174.

 

Luk J.K.H., Cheung R.T.F., Ho S.L. and Li L.S.W., Does age predict outcome in stroke rehabilitation? A study of 878 Chinese subjects, Cerebrovascular Diseases. 2006, 21: 229-234.

 

Ng W., Wong R.W.M., Chen W.H., Tse H.F., Lee P.Y., Lai K.C., Li L.S.W., Ng M.M.T., Lam K.F., Cheng X. and Lau C.P., Incidence and predictors of upper gastrointestinal bleeding in patients receiving low-dose aspirin for secondary prevention of cardiovascular events in patients with coronary artery disease, World Journal of Gastroenterology. Beijing, China, The WJG Press, 2006, 12(18): 2923-2927.

 

Researcher : Li RA



List of Research Outputs

 

Tse H.F., Xue T., Lau C.P., Siu C.W.D., Wang K., Zhang Q.Y., Tomaselli G.F., Akar F.G. and Li R.A., Bioartifical sinus node constructed via in vivo gene transfer of an engineered pacemaker HCN channel reduces the dependence on electronic pacemaker in a sick sinus syndrome model, Circulation. 2006, 114: 1000-1011.

 

Wang K., Xue T., Tsang S.Y., Huizen R.V., Wong C.W., Lai K.W.H., Ye Z., Cheng L., Zhang J.C.L., Li G.R., Lau C.P., Tse H.F. and Li R.A., Electrophysiological Properties of Pluripotent Human and Mouse Embryonic Stem Cells, Stem Cells. 2005, 23: 1526-1534.

 

Researcher : Liang RHS



Project Title:

Quantification of circulating Epstein Barr viral DNA in patients with malignant lymphoma: diagnostic and prognostic significance

Investigator(s):

Liang RHS, Kwong YL, Au WY

Department:

Medicine

Source(s) of Funding:

Small Project Funding

Start Date:

11/2002

 

Abstract:

To define if circulating Epstein-Barr viral (EBV) DNA can be correlated with tumor load in patients with malignant lymphoma; to define the biologic significance and propgnostic value of circulating EBV DNA in malignant lymphoma.

 

Project Title:

Molecular determinants of arsenic resistance in APL and prognostic factors of APL in the post arsenic era

Investigator(s):

Liang RHS, Kwong YL, Au WY

Department:

Medicine

Source(s) of Funding:

Small Project Funding

Start Date:

11/2003

 

Abstract:

To define the relative significance of FLT-3 mutation and aberrant p15 methylation in prognostication of acute promyelocytic leukaemia (APL) in the era of arsenic salvage; to define the molecular role of molecular transport proteins, protein kinase and tumor suppressor genes in arsenic resistant APL.

 

Project Title:

Adoptive transfer of herpes zoster cellular immunity to BMT patients by vaccination of seropositive donors with live-attenuated varicella zoster vaccine

Investigator(s):

Liang RHS, Leung AYH

Department:

Medicine

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

12/2003

 

Abstract:

To study whether the use of live-attenuated VZV vaccine in VZV-seropositive donors prior to BMT achieves three objectives: boosts the cellular and humoral immunity of the donors, transfers immunity to patients post BMT, and protects BMT patients from the development of HZ after transplantation.

 

Project Title:

Adoptive transfer of herpes zoster cellular immunity to BMT patients by vaccination of seropositive donors with live-attenuated varicella zoster vaccine

Investigator(s):

Liang RHS, Leung AYH

Department:

Medicine

Source(s) of Funding:

Merit Award for RGC CERG Funded Projects

Start Date:

12/2003

 

Abstract:

N/A

 

Project Title:

Roles of survivin in the pathogenesis of multiple myeloma and the therapeutic implication of dominant negative survivin in a murine model of human multiple myeloma

Investigator(s):

Liang RHS

Department:

Medicine

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

01/2006

 

Abstract:

Background: Multiple myeloma (MM) is a common blood cancer to which there is no effective cure at present. It is characterized by the presence of abnormal plasma cells which are resistant to apoptotic signals. Angiogenesis in the tumor is also increased. The pathogenesis of MM involves multiple ligand (from microenvironment) and receptors\ (on MM cell surface) interactions, resulting in activation of major signaling pathways, notably the STAT-3, PI3K/Akt and NFkB pathways. These pathways overlap to a considerable extend and targeting any one of them may not impact significantly to the eradication of disease. These have led us to investigate whether a downstream component common to these pathways may provide us with an alternative therapeutic target. In particular, survivin, a member of the inhibitor of apoptotic gene family, is one of the downstream mediators of these pathways and may endow MM cells both with their resistance to apoptosis and increased angiogenesis. Preliminary studies showed that survivin is robustly expressed in both primary MM tissues as well as in a MM cell-line U266. The proposed studies have the following objectives: 1. Investigate the effects of transducing myeloma cells with a dominant negative form of survivin (SurDN) with particular reference to apoptosis and cell-cycle status. Recombinant adeno-associated virus (rAAV) will be used for viral transduction. 2. Establish an in-vivo xenogeneic transplantation model in which eGFP+ MM cells are transplanted into NOD/SCID mice via an intra-femoral route. 3. Investigate the effects of injecting rAAV carrying SurDN on the tumorigenesis of MM cells in this model. Information derived from this project will enable us to address the following issues: 1. Is survivin involved in the pathogenesis of MM, if so, how? 2. Is anti-survivin strategy feasible and efficacious in the treatment of this condition? Results of this project will have important impacts on the following aspects: 1. Explore the therapeutic potential of anti-survivin strategy in the treatment of MM 2. Establish a xenogeneic MM transplantation model that is also important for various therapeutic trials for the treatment of this condition.

 

Project Title:

Effects of all-trans retinoic acid (ATRA) on stromal cells and haematopoietic stem cell engraftment

Investigator(s):

Liang RHS

Department:

Medicine

Source(s) of Funding:

Merit Award for RGC CERG Funded Projects

Start Date:

01/2006

 

Abstract:

N/A

 

Project Title:

Effects of all-trans retinoic acid (ATRA) on stromal cells and haematopoietic stem cell engraftment

Investigator(s):

Liang RHS, Leung AYH

Department:

Medicine

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

01/2006

 

Abstract:

To focus on AFT024 stromal cells but not primary bone marrow stromal cells; to perform one set of microarray and conform the gene expression profile using RT-PCR for those that show differential expression; to focus on the effects of ATRA on human bone marrow cell engraftment in the NOD/SCID mouse model.

 

List of Research Outputs

 

Au W.Y., Cheung W.C., Hu H.C., Chan G.C.F., Ha S.Y., Khong P.L., Ma E.S.K. and Liang R.H.S., Hyperbilirubinaemia and cholelithiasis in Chinese patients with hemoglobin H disease., Annals of Hematology. 2005, 84(10): 671-674.

 

Au W.Y., Lie A.K.W., Cheng J.W., Liang R.H.S. and Kwong Y.L., Long-term donor health and its relationship with outcome of allogeneic hematopoietic stem cell transplantation, Bone Marrow Transplantation. 2006, 37(5): 451-3.

 

Au W.Y., Fung T.K. and Liang R.H.S., Molecular epidemiology of follicular lymphoma in Chinese: relationship with bcl-2IgH translocation and bcl-6 397G/C polymorphism, Annals of Hematology. 2005, 84(8): 506-9.

 

Au W.Y., Chan L.C., Liang R.H.S. and Kwong Y.L., Myelodysplastic syndrome and acute myeloid leukemia after treatment with fludarabine, mitoxantrone, and dexamethasone, American Journal of Hematology. 2006, 81(6): 471-3.

 

Au W.Y., Fung T.K., Ma E.S.K., Chan C.H., Wong K.F., Chim J.C.S., Liang R.H.S. and Kwong Y.L., Serial studies of methylation of CDKN2B and CDKN2A in relapsed acute promyelocytic leukaemia treated with arsenic trioxide, British Journal of Haematology. 2005, 131: 632.

 

Au W.Y., Ma E.S.K., Choy C., Chung L.P., Fung T.K., Liang R.H.S. and Kwong Y.L., Therapy-related lymphomas in patients with autoimmune diseases after treatment with disease-modifying anti-rheumatic drugs, American Journal of Hematology. 2005, 81(1): 5-11.

 

Chan J.C.W., Chim J.C.S., Ooi C.G.C., Cheung B.M.Y., Liang R.H.S., Chan T.K. and Chan V.N.Y., Use of the oral chelator deferiprone in the treatment of iron overload in patients with Hb H disease, British Journal of Haematology. 2006, 133(2): 198-205.

 

Chan V.N.Y., Chan J.C.W., Chim J.C.S., Ooi C.G.C., Cheung B.M.Y., Liang R.H.S. and Chan T.K., Deferiprone in the treatment of iron overload in patients with Hb H disease, XXXth World Congress of the International Society of Hematology, Istanbul, Turkey. Istanbul, Turkey, 2005.

 

Chen W.Y.W., Hu X., Liang A.C.T., Au W.Y., So J.C.C., Wong M.L.Y., Shen L., Tao Q., Chu K.M., Kwong Y.L., Liang R.H.S. and Srivastava G., High BCL6 expression predicts better prognosis, independent of BCL6 translocation status, translocation partner, or BCL6 deregulating mutations, in gastric lymphoma, Blood. 2006, 108(7): 2373-83.

 

Chim J.C.S., Liang R.H.S., Leung S.M.H., Yip S.F. and Kwong Y.L., Aberrant gene promoter methylation marking disease progression in multiple myeloma, Leukemia. 2006, 20(6): 1190-2.

 

Chim J.C.S., Kwong Y.L., Lie A.K.W., Ma E.S.K., Chan C.C., Wong L.G., Kho B.C., Lee H.K., Sim J.P., Chan C.H., Chan J.C., Yeung Y.M., Law W. and Liang R.H.S., Long-term Outcome of 231 Patients With Essential Thrombocythemia , Archives of Internal Medicine. 2005, 165(22): 2651-8.

 

Chim J.C.S., Fung T.K., Wong K.F., Lau J.S., Law M. and Liang R.H.S., Methylation of INK4 and CIP/KIP families of cyclin-dependent kinase inhibitor in chronic lymphocytic leukaemia in Chinese patients, Journal of clinical pathology. 2006, 59(9): 921-6.

 

Hu X., Liang A.C.T., Chen W.Y.W., Tao Q., Wong M.L.Y., Shen L., Wong K.Y., Au W.Y., Cheung W.L., Chu K.M., Kwong Y.L., Liang R.H.S. and Srivastava G., CD44 expression is regulated by translocation and promoter hypermethylation in gastric lymphoma, Proceedings of the 12th Hong Kong International Cancer Congress and 2nd Annual Meeting of Centre for Cancer Research, Hong Kong SAR, China, December 2005.

 

Hu X., Liang A.C.T., Chen W.Y.W., Tao Q., Au W.Y., Wong M.L.Y., Shen L., Wong K.Y., Wan T.S.K., Cheung W.L., Chu K.M., Chan L.C., Kwong Y.L., Liang R.H.S. and Srivastava G., CD44 expression is regulated by translocation and promoter hypermethylation in gastric lymphoma, Proceedings of 97th Annual Meeting of American Association for Cancer Research (AACR), Washington D.C., USA, April 2006 . 2006.

 

Hui C.K., Lie A.K.W., Au W.Y., Leung A.Y.H., Ma S.Y., Cheung W.W., Zhang H., Chim J.C.S., Kwong Y.L., Liang R.H.S. and Lau G., A long-term follow-up study on hepatitis B surface antigen-positive patients undergoing allogeneic hematopoietic stem cell transplantation, Blood. 2005, 106(2): 464-9.

 

Hui C.K., Cheung W., Au W.Y., Lie A.K.W., Zhang H., Yueng Y.H., Wong B.C.Y., Leung N., Kwong Y.L., Liang R.H.S. and Lau G., Hepatitis B reactivation after withdrawal of preemptive lamivudine in patients with hematological malignancy upon completion of cytotoxic chemotherapy, Liver International 2005. 2005, Oct: 182.

 

Hui C.K., Ma S.Y., Sun J., Au W.Y., Lie A.K.W., Chim J.C.S., Kwong Y.L., Liang R.H.S. and Lau G., Hepatitis B reactivation in patient with occult HBV infection after chemotherapy, J Hepatol. 2005, 42(6): 813-19.

 

Hui C.K., Cheung W.W., Zhang H., Au W.Y., Yueng Y.H., Leung A.Y.H., Leung N., Luk J.M.C., Lie A.K.W., Kwong Y.L., Liang R.H.S. and Lau G., Kinetics and risk of de novo hepatitis B infection in HBsAg negative patients undergoing cytotoxic chemotherapy, Gastroenterology. 2006, 131: 59-68.

 

Hui C.K., Cheung W.W., Zhang H., Au W.Y., Yueng Y.H., Leung A.Y.H., Leung N., Luk J.M.C., Lie A.K.W., Kwong Y.L., Liang R.H.S. and Lau G., Rituximab increases the Risk of De Novo hepatitis B infection in Hepatitis B Surface Antigen Negative Patients Undergoing Cytotoxic Chemotherapy, J Gastroenterol and Hepatol. 2006, 21(2): A73.

 

Kwan T.F., Liang R.H.S., Verfaillie C.M., Ekker S.C., Chan L.C., Lin S. and Leung A.Y.H., Regulation of primitive hematopoiesis in zebrafish embryos by the death receptor gene, Experimental Hematology . 2006, 34(1): 27-34.

 

Leung A.Y.H., Leung J.C.K., Chan Y.Y., Ma E.S.K., Kwan T.F., Lai K.N., Meng A. and Liang R.H.S., Proliferating cell nuclear antigen (PCNA) as a proliferative marker during embryonic and adult zebrafish hematopoiesis, Histochemistry and Cell Biology. 2005, 124(2): 105-11.

 

Liang R.H.S., Bone Marrow Transplantation In Hong Kong, Second China-International Leukaemia/Lymphoma Workshop. Guangzhou, 2005.

 

Liang R.H.S., Nasal Nk Cell Lymphoma, Pan-Pacific Lymphoma Conference. Hawaii, USA, 2005.

 

Liang R.H.S., Peripheral T-cell Lymphoma, 4th International Workshop On Non-hodgkin's Lymphoma. Miami, Florida, 2005.

 

Liang R.H.S., T-cell And Natural Killer Cell Lymphoma, 2005t Annual Meeting Of The Korean Cancer Association And The 4th Roche Asian Oncology Forum. Che-Ju, Korea, 2005.

 

Yau T.C., Chu K.W., Mok T.M.Y., Liang R.H.S. and Epstein R., Acute presentation of rheumatoid arthritis following cancer chemotherapy using the topoisomerase I inhibitor irinotecan. , Acta Oncologica. 2005, 44(7): 771-772.

 

Yip B.H., Guo T., Hu X., Wong K.Y., Chen W.Y.W., Au W.Y., Chu K.M., Kwong Y.L., Liang R.H.S. and Srivastava G., Identification of two novel translocations t(14;20)(q32;q12) and t(2;14)(q23;q32) in gastric lymphoma, Proceedings of the 12th Hong Kong International Cancer Congress and 2nd Annual Meeting of Centre for Cancer Research, Hong Kong SAR, China, December 2005.

 

Yip B.H., Guo T., Hu X., Au W.Y., Wong K.Y., Wan T.S.K., Chen W.Y.W., Chu K.M., Chan L.C., Kwong Y.L., Liang R.H.S. and Srivastava G., Identification of two novel translocations t(14;20)(q32;q12) and t(2;14)(q23;q32) involving immunoglobulin heavy chain gene locus in gastric lymphoma, Proceedings of 97th Annual Meeting of American Association for Cancer Research (AACR), Washington D.C., USA, April 2006.

 

Researcher : Lie AKW



List of Research Outputs

 

Au W.Y., Lie A.K.W., Cheng J.W., Liang R.H.S. and Kwong Y.L., Long-term donor health and its relationship with outcome of allogeneic hematopoietic stem cell transplantation, Bone Marrow Transplantation. 2006, 37(5): 451-3.

 

Au W.Y., Cheng V.C.C. and Lie A.K.W., Toxoplasma Gondii Serology and Stem Cell Transplantation in Chinese, Transplantation. 2005, 37(10): 4497-4499.

 

Chim J.C.S., Kwong Y.L., Lie A.K.W., Ma E.S.K., Chan C.C., Wong L.G., Kho B.C., Lee H.K., Sim J.P., Chan C.H., Chan J.C., Yeung Y.M., Law W. and Liang R.H.S., Long-term Outcome of 231 Patients With Essential Thrombocythemia , Archives of Internal Medicine. 2005, 165(22): 2651-8.

 

Hui C.K., Lie A.K.W., Au W.Y., Leung A.Y.H., Ma S.Y., Cheung W.W., Zhang H., Chim J.C.S., Kwong Y.L., Liang R.H.S. and Lau G., A long-term follow-up study on hepatitis B surface antigen-positive patients undergoing allogeneic hematopoietic stem cell transplantation, Blood. 2005, 106(2): 464-9.

 

Hui C.K., Cheung W., Au W.Y., Lie A.K.W., Zhang H., Yueng Y.H., Wong B.C.Y., Leung N., Kwong Y.L., Liang R.H.S. and Lau G., Hepatitis B reactivation after withdrawal of preemptive lamivudine in patients with hematological malignancy upon completion of cytotoxic chemotherapy, Liver International 2005. 2005, Oct: 182.

 

Hui C.K., Ma S.Y., Sun J., Au W.Y., Lie A.K.W., Chim J.C.S., Kwong Y.L., Liang R.H.S. and Lau G., Hepatitis B reactivation in patient with occult HBV infection after chemotherapy, J Hepatol. 2005, 42(6): 813-19.

 

Hui C.K., Cheung W.W., Zhang H., Au W.Y., Yueng Y.H., Leung A.Y.H., Leung N., Luk J.M.C., Lie A.K.W., Kwong Y.L., Liang R.H.S. and Lau G., Kinetics and risk of de novo hepatitis B infection in HBsAg negative patients undergoing cytotoxic chemotherapy, Gastroenterology. 2006, 131: 59-68.

 

Hui C.K., Cheung W.W., Zhang H., Au W.Y., Yueng Y.H., Leung A.Y.H., Leung N., Luk J.M.C., Lie A.K.W., Kwong Y.L., Liang R.H.S. and Lau G., Rituximab increases the Risk of De Novo hepatitis B infection in Hepatitis B Surface Antigen Negative Patients Undergoing Cytotoxic Chemotherapy, J Gastroenterol and Hepatol. 2006, 21(2): A73.

 

Yip S.F., Wan T.S.K., Lie A.K.W., Liu H.S.Y. and Chan L.C., Monitoring of chronic myeloid leukemia (CML) imatinib response by fluorescence-in-situ-hybridization (FISH), American Society of Hematology, Atlanta, Georgia. December 10-13, 2005. Abstract No. 4837. Blood. 2005, 106(11) Part 2: 289b.

 

Researcher : Lin H



List of Research Outputs

 

Li G., Xia H.H.X., Chen M., Gu Q., Wang J., Peng J., Chan O.O., Cho C.H., So H.L., Lam S.K., Hu P.J., Liang Y.J., Lin H., Berg D.E., Feng Z.H., Langenback R. and Wong B.C.Y., Effects of Cyclooxygenase-1 and -2 Gene Disruption on Helicobacter pylori-Induced Inflammation, Journal of Infectious Diseases. 2006, 193(7): 1037-1046.

 

Researcher : Lio WI



List of Research Outputs

 

Tse K.C., Tang C.S.O., Lio W.I., Lam M.F. and Chan D.T.M., Quality of life comparison between corticosteroid-and-mycofenolate mofetil and corticosteroid-and-oral cyclophosphamide in the treatment of severe lupus nephritis, Lupus. 2006, 15(6): 371-379.

 

Researcher : Liu H



List of Research Outputs

 

Li G.R., Liu H. and Lau C.P., Modulation of cardiac voltage-gated sodium current by the interplay of protein tyrosine kinase and phosphatases, Biophyscal Journal. 2006, 90: 435a-436a.

 

Liu H., Jin M.W., Xiang J.Z., Huang Y., Chiu S.W., Lau C.P. and Li G.R., Effects of raloxifene on action potential, transient outward and ultra-rapid delayed rectifier potassium current in human atrial myocytes., Journal of Hong Kong College Cardiology/The 9th Institute of Cardiovascular Science and Medicine & the 5th Scientific Conference on Cardiovascular Science Across the Strait. 2005, 13:111-OP60.

 

Researcher : Lo WK



List of Research Outputs

 

Kwong Y.L., Lau W.C.S., Ho S.L., Epstein R., Young R.T.T., Chan H.H.L., Tse H.F., Lam L., Chen W.H., Lee K.L.F., Ip M.S.M., Tsang K.W.T., Lam B., Tang S.C.W., Chan R.H.W., Lee S.W.L., Tan K.C.B., Yeung C.K., Chan D.T.M., Wong R.W.S., Choy C.B.Y., Wong B.C.Y., Li F.K., Lo W.K., Lui S.L., Cheung R.T.F., Mak W., Ho J.C.M., Mok T.M.Y., Kung A.W.C., Cheung B.M.Y., Chow W.S., Yuen R.M.F. and Wat N.M.S., In: Lau CP, Kumana CR, Lai CL, Lai KN, Lam KSL, Lam WK, Problem-Based Medical Case Management. Hong Kong, Hong Kong University Press, 2005.

 

Lam M.F., Leung J.C.K., Lo W.K., Lui S.L., Chan D.T.M. and Lai K.N., Increased serum leptin levels during peritoneal dialysis related peritonitis associated with prolonged inflammation and loss of lean body mass, Journal of American Society of Nephrology. 2005, 16: 713A.

 

Lam M.F., Leung J.C.K., Tang C.S.O., Lo W.K., Tse K.C., Yip T.P.S., Lui S.L., Chan D.T.M. and Lai K.N., Mannose binding lectin level and polymorphism in patients on long-term peritoneal dialysis, Nephrology Dialysis Transplantation. 2005, 20: 2489-2496.

 

Lui S.L., Cheng S.W., Ng F.S.K., Ng S.Y., Wan K.M., Yip T., Tse K.C., Lam M.F., Lai K.N. and Lo W.K., Cefazolin plus netilmicin versus cefazolin plus ceftazidime for treating CAPD peritonitis: effect on residual renal function, Kidney International. 2005, 68(5): 2375-2380.

 

Lui S.L., Yip T., Tse K.C., Lam M.F., Lai K.N. and Lo W.K., Treatment of refractory pseudomonas aeruginosa exit-site infection by simultaneous removal and reinsertion of peritoneal dialysis catheter, Peritoneal Dialysis International. 2005, 25(6): 560-563.

 

Yip T.P.S., Tse K.C., Lam M.F., Tang S.C.W., Li F.K., Choy C.B.Y., Lui S.L., Chan D.T.M., Lai K.N. and Lo W.K., Risk factors and outcomes of extended-spectrum beta-lactamase-producing E. coli peritonitis in CAPD patients, Peritoneal Dialysis International. 2006, 26(2): 191-197.

 

Researcher : Lu L



List of Research Outputs

 

Lu L., Hui C.K., Zhang H., Yueng Y.H., Cheung K.F. and Lau G., Quantification and Correlation of HBV DNA and RNA inPeripheral Blood Mononuclear Cells adn HBV DNA in Serum in Chronic Hepatitis B, J Gastroenterol and Hepatol. 2006, 21(2): A77.

 

Researcher : Lu M



List of Research Outputs

 

Jin Y., Feng H., Deng W., Zhang H., Lu M., Jin C., Tsao G.S.W. and Kwong Y.L., Immortalization of human extravillous cytotrophoblasts by human papilloma virus gene E6E7: sequential cytogenetic and molecular genetic characterization, Cancer Genetics and Cytogenetics. 2005, 163: 30-37.

 

Researcher : Lui RYH



List of Research Outputs

 

Tang S., Lai F.M., Lui R.Y.H., Tang C.S.O., Kung N.N.S., Ho Y.W., Chan K.W., Leung J.C.K. and Lai K.N., Lamivudine in hepatitis B-associated membranous nephropathy, Joint symposium on extracorporeal support for multi-organ failure organized by Hong Kong College of Physicians Scientific Symposium and Hong Kong Society of Nephrology Annual Scientific Meeting, 10-11 September 2005, Hong Kong. 2005.

 

Researcher : Lui SL



List of Research Outputs

 

Guo H., Leung J.C.K., Chan L.Y., Lui S.L., Tsang W.L. and Lai K.N., Modulation of intra-pulmonary TGF-beta expression by mycophenolate mofetil in lupus prone MRL/lpr mice, Lupus. 2005, 14(8): 583-592.

 

Kwong Y.L., Lau W.C.S., Ho S.L., Epstein R., Young R.T.T., Chan H.H.L., Tse H.F., Lam L., Chen W.H., Lee K.L.F., Ip M.S.M., Tsang K.W.T., Lam B., Tang S.C.W., Chan R.H.W., Lee S.W.L., Tan K.C.B., Yeung C.K., Chan D.T.M., Wong R.W.S., Choy C.B.Y., Wong B.C.Y., Li F.K., Lo W.K., Lui S.L., Cheung R.T.F., Mak W., Ho J.C.M., Mok T.M.Y., Kung A.W.C., Cheung B.M.Y., Chow W.S., Yuen R.M.F. and Wat N.M.S., In: Lau CP, Kumana CR, Lai CL, Lai KN, Lam KSL, Lam WK, Problem-Based Medical Case Management. Hong Kong, Hong Kong University Press, 2005.

 

Lam M.F., Leung J.C.K., Lo W.K., Lui S.L., Chan D.T.M. and Lai K.N., Increased serum leptin levels during peritoneal dialysis related peritonitis associated with prolonged inflammation and loss of lean body mass, Journal of American Society of Nephrology. 2005, 16: 713A.

 

Lam M.F., Leung J.C.K., Tang C.S.O., Lo W.K., Tse K.C., Yip T.P.S., Lui S.L., Chan D.T.M. and Lai K.N., Mannose binding lectin level and polymorphism in patients on long-term peritoneal dialysis, Nephrology Dialysis Transplantation. 2005, 20: 2489-2496.

 

Lui S.L., Cheng S.W., Ng F.S.K., Ng S.Y., Wan K.M., Yip T., Tse K.C., Lam M.F., Lai K.N. and Lo W.K., Cefazolin plus netilmicin versus cefazolin plus ceftazidime for treating CAPD peritonitis: effect on residual renal function, Kidney International. 2005, 68(5): 2375-2380.

 

Lui S.L., Chan K.W., Tsang R.C.W., Yung S.S.Y., Lai K.N. and Chan D.T.M., Effect of rapamycin on renal ischemia reperfusion injury, Joint symposium on extracorporeal support for multi-organ failure organized by Hong Kong College of Physicians Scientific Symposium and Hong Kong Society of Nephrology Annual Scientific Meeting, 10-11 September 2005, Hong Kong. 2005.

 

Lui S.L., Yip T., Tse K.C., Lam M.F., Lai K.N. and Lo W.K., Treatment of refractory pseudomonas aeruginosa exit-site infection by simultaneous removal and reinsertion of peritoneal dialysis catheter, Peritoneal Dialysis International. 2005, 25(6): 560-563.

 

Yip T.P.S., Tse K.C., Lam M.F., Tang S.C.W., Li F.K., Choy C.B.Y., Lui S.L., Chan D.T.M., Lai K.N. and Lo W.K., Risk factors and outcomes of extended-spectrum beta-lactamase-producing E. coli peritonitis in CAPD patients, Peritoneal Dialysis International. 2006, 26(2): 191-197.

 

Researcher : Luk JKH



List of Research Outputs

 

Luk J.K.H., Cheung R.T.F., Ho S.L. and Li L.S.W., Does age predict outcome in stroke rehabilitation? A study of 878 Chinese subjects, 4th World Congress for NeuroRehabilitation. 2006, 20: 174.

 

Luk J.K.H., Cheung R.T.F., Ho S.L. and Li L.S.W., Does age predict outcome in stroke rehabilitation? A study of 878 Chinese subjects, Cerebrovascular Diseases. 2006, 21: 229-234.

 

Tam T.C., Chan K.Y., Ho S.L., Luk J.K.H. and Chu L.W., Herpetic shoulder paresis in a Chinese elderly patient., Hong Kong Medical Journal. 2005, 11: 399-402.

 

Researcher : Mak JCW



Project Title:

Effects of pseudomonas aeruginosa pyocyanin and 1-hydroxyphenazine on the regulation of glucocorticoid receptor activation and function in airway epithelial cells in vitro

Investigator(s):

Mak JCW, Tsang KWT

Department:

Medicine

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

11/2003

 

Abstract:

To evaluate the effects of Pseudomonas aeruginosa (PA) exotoxins, pyocyanin (PYO) and 1-hydroxyphenazine (1-HP), on the functional and immunological aspects of human airway epithelial cells in vitro, and examine the signaling pathways involved in PYO- or 1-HP-induced responses; to assess the efficacy of various potential novel therapeutic and chemical agents on the effects of these toxins.

 

Project Title:

Effects of pseudomonas aeruginosa pyocyanin and 1-hydroxyphenazine on the regulation of glucocorticoid receptor activation and function in airway epithelial cells in vitro

Investigator(s):

Mak JCW, Tsang KWT

Department:

Medicine

Source(s) of Funding:

Merit Award for RGC CERG Funded Projects

Start Date:

11/2003

 

Abstract:

N/A

 

Project Title:

Is there an association between TGF-[beta]1 plasma levels and common polymorphisms with a risk of developing chronic obstructive pulmonary disease (COPD)?

Investigator(s):

Mak JCW, Tsang KWT, Chan MMW

Department:

Medicine

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

02/2004

Completion Date:

07/2005

 

Abstract:

To study the promoter and coding regions of the TGF-[beta]1 gene, identify single nucleotide polymorphisms (SNP) in Hong Kong Chinese (i.e. healthy nonsmokers and smokers and patients with COPD) and correlate these with plasma TGF-[beta]1 level.

 

Project Title:

Role of transforming growth factor-beta1 variants in susceptibility to tuberculosis in Hong Kong Chinese population

Investigator(s):

Mak JCW, Chan MMW

Department:

Medicine

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

02/2005

 

Abstract:

i) To study the role of two common single nucleotide polymorphisms (SNPs) at the promoter (C-509T) and coding regions (T869C) of the TGF-beta1 gene in conferring susceptibility to the development of tuberculosis (TB) in Hong Kong Chinese population. ii) To perform functional analysis in correlating the associated polymorphisms with the plasma level of TGF-beta1 in TB patients and healthy controls. iii) To conduct a study in determining the proportion of patients with chronic obstructive pulmonary disease (COPD) with a past history of tuberculosis since COPD is a major cause of respiratory disability in Hong Kong.

 

List of Research Outputs

 

Ho J.C.M., Mak J.C.W., Ho S., Ip M.S.M., Tsang K.W.T., Lam W.K. and Chan M.M.W., Manganese superoxide dismutase and catalase genetic polymorphisms, activity levels and lung cancer risk in Chinese in Hong Kong. 11th World Conference on Lung Cancer , Lung Cancer. 2005, 49(Suppl 2): S191.

 

Kwok R.P., Sun J.Z., Tipoe G.L., Leung Y.H., Yan C.P.K., Ooi C.G.C., Ho P.L., Mak J.C.W., Lam W.K. and Tsang K.W.T., Pseudomonas aeruginosa pyocyanin : discruption of ultrastructure of human respiratory mucosa in vitro, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong,. 2006, Abstract Book 087: pp. 55.

 

Kwok R.P., Sun J.Z., Tipoe G.L., Leung Y.H., Yan C.P.K., Ooi C.G.C., Ho P.L., Mak J.C.W., Lam W.K. and Tsang K.W.T., Pseudomonas aeruginosa pyocyanin : discruption of ultrastructure of human respiratory mucosa in vitro, Respirology. 2005, 10 (Suppl): A126 (#170).

 

Mak J.C.W., Leung C.M., Ho S.P., Law K.W., Ho A.S.S., Lam W.K., Ip M.S.M. and Chan M.M.W., Analysis of transforming growth factor-beta(1) gene polymorphisms in Hong Kong Chinese asthmatic patients, Journal of Allergy and Clinical Immunology. 2006, 117: 92-96.

 

Mak J.C.W., Leung C.M., Ho S.P., Law K.W., Tsang K.W.T., Lam W.K., Ip M.S.M. and Chan M.M.W., Best Poster - Genetic Susceptibility Of Transforming Growth Factor-beta1 Common Polymorphisms To Chinese Patients With Asthma, Hong Kong Allergy Convention 2005 . 2005.

 

Mak J.C.W., Ho S.P., Leung Y.H., Ho P.L., Ooi C.G.C., Tipoe G.L., Yan C.P.K., Ip M.S.M., Lam W.K. and Tsang K.W.T., Elevated levels of transforming growth factor-beta(1) in serum of patients with stable bronchiectasis, Respiratory Medicine. 2005, 99: 1223-1228.

 

Mak J.C.W., Leung C.M., Ho S.P., Law K.W., Tsang K.W.T., Lam W.K., Ip M.S.M. and Chan M.M.W., Genetic susceptibility of transforming growth factor-beta(1) common polymorphisms to Chinese patients with asthma, Hong Kong Allergy Convention, Hong Kong. 2005, Abstract AB25: p.54.

 

Mak J.C.W., Ho S.P., Leung C.M., Lam W.K., Ip M.S.M. and Chan M.M.W., Genetic susceptibility to chronic obstructive pulmonary disease (COPD) : Transforming growth factor-beta common polymorphisms and plasma levels, American Journal of Respiratory and Critical Care Medicine. 2006, 173(3): A624.

 

Mak J.C.W., Ho S.P., Leung C.M., Lam W.K., Ip M.S.M. and Chan M.M.W., Genetic susceptibility to chronic obstructive pulmonary disease (COPD) : transforming growth factor-beta(1) common polymorphisms and plasma levels, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong, January 2006. Abstract Book 089: pp.56.

 

Mak J.C.W., Hui W.S., Ho S.P., So W.H.L., Chan M.M.W., Cho C.H. and Lam W.K., Inducation of CINC-1 in the lung tissue from rats exposed to cigarette smoke, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2006, Abstract Book 088: pp. 55.

 

Mak J.C.W., Hui W.S., Ho S.P., So W.H., Chan M.M.W., Cho C.H. and Lam W.K., Induction of CINC-1 in the lung tissue from rats exposed to cigarette smoke, American Journal of Respiratory and Critical Care Medicine. 2006, 173(3): A634.

 

Mak J.C.W., Leung C.M., Ho S.P., Ko F.W.S., Cheung A.H.K., Ip M.S.M. and Chan M.M.W., Polymorphisms in manganese superoxide dismutase and catalase genes - functional study in Hong Kong Chinese asthma patients , Clinical and Experimental Allergy. 2006, 36: 440-447.

 

Mak J.C.W., Ho J.C.M., Ho S.P., Leung C.M., Law K.W., Lam W.K., Ip M.S.M. and Chan M.M.W., Polymorphisms in superoxide dismutase (SOD) and catalase genes - functional study in Chinese patients with asthma, Hong Kong Allergy Convention, Hong Kong. 2005, Abstract AB26: p.54.

 

Mak J.C.W. and Chan M.M.W., Reactive oxidant species in asthma. , Current Opinion in Pulmonary Medicine. 2006, 12(1): 7-11.

 

Mak J.C.W., Hui W.S., Tipoe G.L., Lam W.K. and Tsang K.W.T., Regulation of cytokine- and phorbol ester-mediated interleukin (IL)-8 expression in the absence of presence of pyocyanin in human bronchial epithelial cell line: roles of protein kinase C and mitogen-activated protein kinases, European Respiratory Journal. 2005, 26 (Suppl 49): 99S (#709).

 

Mak J.C.W., Ho S.P., Wong M.P., Tsang K.W.T., Ip M.S.M., Lam W.K. and Chan M.M.W., Transforming growth factor (TGF)-b[sub]1[/sub] gene common polymorphisms and plasma TGF-b[sub]1[/sub] levels in patients with lung cancer, European Respiratory Journal. 2005, 26 (Suppl 49): 435S (#2797).

 

Pan N.Y., Hui W.S., Tipoe G.L., Lam W.K., Tsang K.W.T. and Mak J.C.W., Effects of glucocorticosteroids and antimicrobial drugs on inhibition of IL-1-beta and PDBu-induced IL-8 release in the presence of pyocyanin in bronchial epithelial cell line, European Respiratory Journal. 2005, 26(Suppl 49): 99s.

 

Researcher : Mak W



List of Research Outputs

 

Chan K.H., Mak W., Cheung R.T.F., Cheng T.S. and Ho S.L., Muscle-specific kinase autoantibody in acetylcholine receptor antibody-negative generalized acquired myasthenia gravis, 11th Medical Research Conference, Medical Science Group. 2006, 80.

 

Fong C.Y.G., Cheng T.S., Lam K., Cheng W.K., Mok B.K.Y., Cheung C.M., Chim J.C.S., Mak W., Chan K.H., Tsang K.L., Kwan M.C., Tsoi T.H., Cheung R.T.F. and Ho S.L., An epidemiological study of motor neuron disease in Hong Kong, Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. 168, 2005, 6: 164.

 

Kwong Y.L., Lau W.C.S., Ho S.L., Epstein R., Young R.T.T., Chan H.H.L., Tse H.F., Lam L., Chen W.H., Lee K.L.F., Ip M.S.M., Tsang K.W.T., Lam B., Tang S.C.W., Chan R.H.W., Lee S.W.L., Tan K.C.B., Yeung C.K., Chan D.T.M., Wong R.W.S., Choy C.B.Y., Wong B.C.Y., Li F.K., Lo W.K., Lui S.L., Cheung R.T.F., Mak W., Ho J.C.M., Mok T.M.Y., Kung A.W.C., Cheung B.M.Y., Chow W.S., Yuen R.M.F. and Wat N.M.S., In: Lau CP, Kumana CR, Lai CL, Lai KN, Lam KSL, Lam WK, Problem-Based Medical Case Management. Hong Kong, Hong Kong University Press, 2005.

 

Li Y., Leung W.C.W., Chen Y., Cheung B.M.Y., Liang R.Y.H., Yik P.Y., Ng K.M., Mak W., Jin D., st. George-Hyslop P. and Song Y., Intron 2 (T/C) CYP46 polymorphism is associated with Alzheimer's disease in Chinese. , Dement Geriatr Cogn Disord. 2006, 22: 399-404.

 

Mak W., Cheng T.S., Chan K.H., Cheung R.T.F. and Ho S.L., A possible explanation for the racial difference in distribution of large-arterial cerebrovascular disease: Ancestral European settlers evolved genetic resistance to atherosclerosis, but confined to the intracranial arteries, Medical Hypotheses. 2005, 65: 637-648.

 

Mak W., Kwan M.W., Cheng T.S., Chan K.H., Cheung R.T.F. and Ho S.L., Cerebrospinal fluid to serum glucose ratio in non-hypoglycorrhachic conditions, Hong Kong Medical Journal. 2005, 11: 457-462.

 

Mak W., Kwan M.W.M., Cheng T.S., Chan K.H., Cheung R.T.F. and Ho S.L., Myopia as a latent phenotype of a pleiotropic gene positively selected for facilitating neurocognitive development, and the effects of environmental factors in its expression, Medical Hypotheses. 2006, 6: 1209-1215.

 

Mak W., Cheng T.S., Leung K.P., Li L.S.W. and Ho S.L., PBL video trigger on "Motor Neuron Disease", TDG projectVirtual Reality Teaching and Learning Resource Bank for Medical Education.. 2006.

 

Researcher : Man YB



List of Research Outputs

 

Cheung B.M.Y., Leung R.Y.H., Man Y.B., Ong K.L., Wong L.Y.F., Lau C.P. and Lam K.S.L., Association of hypertension with single nucleotide polymorphisms in the quantitative trait locus for abdominal obesity-metabolic syndrome on chromosome 17, J Hum Hyperten. 2006.

 

Cheung B.M.Y., Ong K.L., Man Y.B., Lam K.S.L. and Lau C.P., Prevalence, Awareness, Treatment, and Control of Hypertension: United States National Health and Nutrition Examination Survey 2001-2, Journal of Clinical Hypertension. United States, Elsevier, 2006, 8: 93-98.

 

Researcher : Mok BKY



List of Research Outputs

 

Fong C.Y.G., Cheng T.S., Lam K., Cheng W.K., Mok B.K.Y., Cheung C.M., Chim J.C.S., Mak W., Chan K.H., Tsang K.L., Kwan M.C., Tsoi T.H., Cheung R.T.F. and Ho S.L., An epidemiological study of motor neuron disease in Hong Kong, Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. 168, 2005, 6: 164.

 

Researcher : Mok TMY



List of Research Outputs

 

Chim J.C.S., PANG Y.Y., Ooi G.C., Mok T.M.Y. and SHEK T.W., EBV-associated synovial lymphoma in a Chronically Inflamed Joint in Rheumatoid Arthritis Receiving Prolonged Methotrexate Treatment, Haematologica. 2006, 91: 8 suppl.

 

Kwong Y.L., Lau W.C.S., Ho S.L., Epstein R., Young R.T.T., Chan H.H.L., Tse H.F., Lam L., Chen W.H., Lee K.L.F., Ip M.S.M., Tsang K.W.T., Lam B., Tang S.C.W., Chan R.H.W., Lee S.W.L., Tan K.C.B., Yeung C.K., Chan D.T.M., Wong R.W.S., Choy C.B.Y., Wong B.C.Y., Li F.K., Lo W.K., Lui S.L., Cheung R.T.F., Mak W., Ho J.C.M., Mok T.M.Y., Kung A.W.C., Cheung B.M.Y., Chow W.S., Yuen R.M.F. and Wat N.M.S., In: Lau CP, Kumana CR, Lai CL, Lai KN, Lam KSL, Lam WK, Problem-Based Medical Case Management. Hong Kong, Hong Kong University Press, 2005.

 

Mok T.M.Y., Wong S.Y., Chan D.T.M., Tang W.M., Wong R.W.S. and Lau W.C.S., Necrotising Fasciitis in Rheumatic Diseases, Lupus. 2006, 15: 380-3.

 

Yau T.C., Chu K.W., Mok T.M.Y., Liang R.H.S. and Epstein R., Acute presentation of rheumatoid arthritis following cancer chemotherapy using the topoisomerase I inhibitor irinotecan. , Acta Oncologica. 2005, 44(7): 771-772.

 

Researcher : Ng FH



List of Research Outputs

 

Chan O.O., Jim M.H., Lam K.F., Siu D.C.W., Tong S.M., Ng F.H., Hui W.M., Chan C.K., Lai K.C., Hu H.C., Yuen R.M.F., Lau Y.K., Lee S.W.L., Lam S.K. and Wong B.C.Y., Patients with Coronary Artery Disease are at High Risk for Developing Colorectal Cancer and Adenoma: An Interim Analysis of a Prospective Study, Gastroenterology. 2006, 130 (4 Supp 2): A-36.

 

Researcher : Ng FSK



List of Research Outputs

 

Lui S.L., Cheng S.W., Ng F.S.K., Ng S.Y., Wan K.M., Yip T., Tse K.C., Lam M.F., Lai K.N. and Lo W.K., Cefazolin plus netilmicin versus cefazolin plus ceftazidime for treating CAPD peritonitis: effect on residual renal function, Kidney International. 2005, 68(5): 2375-2380.

 

Researcher : Ng MMT



List of Research Outputs

 

Ng W., Wong R.W.M., Chen W.H., Tse H.F., Lee P.Y., Lai K.C., Li L.S.W., Ng M.M.T., Lam K.F., Cheng X. and Lau C.P., Incidence and predictors of upper gastrointestinal bleeding in patients receiving low-dose aspirin for secondary prevention of cardiovascular events in patients with coronary artery disease, World Journal of Gastroenterology. Beijing, China, The WJG Press, 2006, 12(18): 2923-2927.

 

Researcher : Ng MYM



List of Research Outputs

 

Kung A.W.C., Lai M.H., Ng M.Y.M., Cheung W.M.W., Chan V.N.Y. and Sham P.C., Estrogen receptor beta polymorphisms predict risks of osteoporosis in men and women: A linkage and association study, 27th Annual Meeting of the American Society for Bone & Mineral Research, 23-27 September 2005, Nashville, USA. 2005.

 

Kung A.W.C., Lai M.H., Ng M.Y.M., Chan V.N.Y. and Sham P.C., T-1213C polymorphism of estrogen receptor beta is associated with low bone mineral density and osteoporotic fractures, Bone. 2006.

 

Lau H.L., Ng M.Y.M., Cheung W.M.W., Paterson A.D., Sham P.C., Luk K.D.K., Chan V.N.Y. and Kung A.W.C., Assessment of linkage and association of 13 genetic loci with bone mineral density, Journal of Bone and Mineral Metabolism. 2006, 24: 226-34.

 

Lau H.L., Ng M.Y.M., Jin L., Paterson A., Sham P.C., Luk K.D.K., Chan V.N.Y. and Kung A.W.C., Test of linkage and association of 14 genetic loci with bone size, 27th Annual Meeting of the American Society for Bone & Mineral Research, 23-27 September 2005, Nashville, USA. 2005.

 

Researcher : Ng WS



List of Research Outputs

 

Cheung W.M.W., Ng W.S. and Kung A.W.C., Dimethyl Sulfoxide enhances osteoblastic differentiation of murine pre-osteoblast cells, 27th Annual Meeting of the American Society for Bone & Mineral Research, September 23-27, 2005, Tennessee, USA. Journal of Bone and Mineral Research, M208. 2005.

 

Cheung W.M.W., Ng W.S. and Kung A.W.C., Dimethyl sulfoxide as an inducer of differentiation in preosteoblast MC3T3-E1 cells, FEBS Letter. 2006, 580: 121-6.

 

Researcher : Ngai WS



List of Research Outputs

 

Wong D.K.H., Yuen R.M.F., Ngai W.S. and Lai C.L., One-year treatment of entecavir results in reduction in intrahepatic covalently closed circular DNA level, Hepatology. 2005, 42(Suppl 1): 573A.

 

Researcher : Ong KL



List of Research Outputs

 

Cheung B.M.Y., Leung R.Y.H., Man Y.B., Ong K.L., Wong L.Y.F., Lau C.P. and Lam K.S.L., Association of hypertension with single nucleotide polymorphisms in the quantitative trait locus for abdominal obesity-metabolic syndrome on chromosome 17, J Hum Hyperten. 2006.

 

Cheung B.M.Y., Ong K.L., Man Y.B., Lam K.S.L. and Lau C.P., Prevalence, Awareness, Treatment, and Control of Hypertension: United States National Health and Nutrition Examination Survey 2001-2, Journal of Clinical Hypertension. United States, Elsevier, 2006, 8: 93-98.

 

Researcher : Ong KL



List of Research Outputs

 

Cheung B.M.Y., Leung R.Y.H., Man Y.B., Ong K.L., Wong L.Y.F., Lau C.P. and Lam K.S.L., Association of hypertension with single nucleotide polymorphisms in the quantitative trait locus for abdominal obesity-metabolic syndrome on chromosome 17, J Hum Hyperten. 2006.

 

Cheung B.M.Y., Ong K.L., Man Y.B., Lam K.S.L. and Lau C.P., Prevalence, Awareness, Treatment, and Control of Hypertension: United States National Health and Nutrition Examination Survey 2001-2, Journal of Clinical Hypertension. United States, Elsevier, 2006, 8: 93-98.

 

Researcher : Ooi GC



List of Research Outputs

 

Chim J.C.S., PANG Y.Y., Ooi G.C., Mok T.M.Y. and SHEK T.W., EBV-associated synovial lymphoma in a Chronically Inflamed Joint in Rheumatoid Arthritis Receiving Prolonged Methotrexate Treatment, Haematologica. 2006, 91: 8 suppl.

 

Researcher : Pan NY



List of Research Outputs

 

Pan N.Y., Hui W.S., Tipoe G.L., Lam W.K., Tsang K.W.T. and Mak J.C.W., Effects of glucocorticosteroids and antimicrobial drugs on inhibition of IL-1-beta and PDBu-induced IL-8 release in the presence of pyocyanin in bronchial epithelial cell line, European Respiratory Journal. 2005, 26(Suppl 49): 99s.

 

Researcher : Pang AWK



List of Research Outputs

 

Au W.Y., Lam C.C.K., Chim J.C.S., Pang A.W.K. and Kwong Y.L., Alemtuzumab induced complete remission of therapy-resistant pure red cell aplasia , Leukemia Research . 2005, 29, Issue 10: 1213-1215.

 

Au W.Y., Pang A.W.K., Wan T.S.K., Ma E.S.K., Cheng L.C. and Kwong Y.L., Concomitant post-transplantation lymphoproliferative disease and therapy-related myelodysplastic syndrome after lung transplantation , The Journal of Heart and Lung Transplantation . 2006, 25(2): 259-260.

 

Au W.Y., Pang A.W.K., Chan C., Chu K.M., Shek T.W.H. and Kwong Y.L., Epstein-barr virus-related gastric adenocarcinoma: an early secondary cancer post hemopoietic stem cell transplantation, Gastroenterology. 2005, 129(6): 2058-63.

 

Chim J.C.S., Wong A.S.P., Pang A.W.K., Chu P., Lau J.S., Wong K.F. and Kwong Y.L., Aberrant promoter methylation of the retinoic acid receptor alpha gene in acute promyelocytic leukemia, Leukemia. 2005, 19(22): 2241-6.

 

Chim J.C.S., Chan W.W.L., Pang A.W.K. and Kwong Y.L., Preferential methylation of Wnt inhibitory factor-1 in acute promyelocytic leukemia: an independent poor prognostic factor, Leukemia. 2006, 20(5): 907-9.

 

Researcher : Pang RWC



List of Research Outputs

 

Pang R.W.C., Poon R.T.P., Lee K.W., Fan S.T., Kwong Y.L. and Tse E.W.C., PIN1 interacts with a specific serine-proline motif of hepatitis B virus X protein to enhance hepatocarcinogenesis (Abstract), The 97th Annual Meeting of the American Association of Cancer Research, Washington D.C., U.S.A., 1 - 5 April 2006.

 

Researcher : Peng J



List of Research Outputs

 

Chan O.O., Peng J., Lam S.K., Lai K.C., Yuen R.M.F., Cheung K.L., Kwong Y.L., Rashid A., Chan C.K. and Wong B.C.Y., Eradication of Helicobacter pylori Infection Reverses E-cadherin Promoter Hypermethylation, Gut. 2006, 55: 463-468.

 

Li G., Xia H.H.X., Chen M., Gu Q., Wang J., Peng J., Chan O.O., Cho C.H., So H.L., Lam S.K., Hu P.J., Liang Y.J., Lin H., Berg D.E., Feng Z.H., Langenback R. and Wong B.C.Y., Effects of Cyclooxygenase-1 and -2 Gene Disruption on Helicobacter pylori-Induced Inflammation, Journal of Infectious Diseases. 2006, 193(7): 1037-1046.

 

Researcher : Ren Y



Project Title:

Proteomics computational analysis of Severe Acute Respiratory Syndrome

Investigator(s):

Ren Y, Tam PKH, Peiris JSM, He Q, Fan J.Q.

Department:

Surgery

Source(s) of Funding:

VCO SARS Research Fund

Start Date:

07/2003

 

Abstract:

To investigate by using proteomics approach, combining Western blotting and ELISA: (a) identification of specific pattern in serum for the diagnosis and prognosis, (b) detection of immune-relevant proteins in SARS, (c) detection of proteins in different stages of SARS patients, (d) proteome analysis of SCV (proteome maps), (e) detection of expression patterns in virus infected cells.

 

List of Research Outputs

 

Researcher : Shen J



Project Title:

Effects of Buyang Huanwu Decoction on neuronal regeneration after ischemic brain injury

Investigator(s):

Shen J, Fung PCW, Tong L.

Department:

Medicine

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

02/2004

 

Abstract:

To evaluate the effects of Buyang Huanwu Decoction, a classical formula of Traditional Chinese Medicine (TCM), and its major component Astragalus membranaceus on the regeneration of neurons after ischemic brain injury.

 

Project Title:

Plasma membrane cholesterol homeostasis and oxidative stress: implication for neuronal oxidative damage in ischemia stroke

Investigator(s):

Shen J

Department:

Medicine

Source(s) of Funding:

Merit Award for RGC CERG Funded Projects

Start Date:

01/2005

Completion Date:

10/2005

 

Abstract:

N/A

 

Project Title:

Plasma membrane cholesterol homeostasis and oxidative stress: implication for neuronal oxidative damage in ischemia stroke

Investigator(s):

Shen J, Cheung RTF, Fung PCW, Liu K.J.

Department:

Medicine

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

01/2005

Completion Date:

12/2006

 

Abstract:

To investigate the reole of plasma membrane cholesterol in regulating cellular oxygen supply and ROS production in MCAO ischemia-reperfused model; to investigate which cholesterol pools, free cholesterol, choelsterol ester or oxysterols, would aggravate neuronal oxidative damage in ischemia-reperfused neuronal cells; to test the hypothesis that caveolin-1 may be a important target protein linking with neuronal oxidative damage and abnormal choletserol metabolism.

 

List of Research Outputs

 

Chan P.S., Shen J., Fung P.C.W. and Cheung R.T.F., NPY acts on its Y1 receptor via Ca2+ as the second messenger to cause NO overproduction and mediate cell injury following oxygen and glucose deprivation in SK-N-MC cells, 11th Medical Research Conference, Medical Science Group. 2006, 81.

 

Researcher : Shiu SWM



List of Research Outputs

 

Lee K.K., Shiu S.W.M., Wong Y., Wong W.K. and Tam S., Plasma apolipoprotein E is a major determinant of phospholipid transfer protein activity in type 2 diabetes mellitus, The 6th International Diabetes Federation Western Pacific Region Congress, Bangkok, Oct 2005.

 

Tan K.C.B., Chow W.S., Shiu S.W.M., Bucala R. and Betteridge D.J., Increased serum level of soluble receptor for advanced glycation end products in type 2 diabetic patients with nephropathy, International Symposium on Healthy Aging, Hong Kong. 2006.

 

Tan K.C.B., Shiu S.W.M., Wong Y., Wong W.K. and Tam S., Plasma apolipoprotein E concentration is an important determinant of phospholipid transfer protein activiity in type 2 diabetes mellitus, Diabetes Metab Res Rev. 2006.

 

Tan K.C.B., Chow W.S., Shiu S.W.M., Bucala R. and Betteridge D.J., Serum level of soluble receptor for advanced glcyation end products is associated with circulating advanced glycation end products in type 2 diabetes, XIV International Symposium on Atherosclerosis, Rome. 2006.

 

Zhou H., Shiu S.W.M., Wong Y. and Tan K.C.B., Association between advanced glycation end products and reduced activity of HDL to protect LDL against oxidation in type 2 diabetes mellitus, American Diabetes Association 66th Scientific Sessions, Washington. 2006.

 

Zhou H., Shiu S.W.M., Wong Y. and Tan K.C.B., Decreased activity of HDL to protect LDL against oxidation in type 2 diabetic patients with nephropathy, 5th Congress of Asian Pacific Society of Atherosclerosis and Vascular Diseases. 2006.

 

Zhou H., Shiu S.W.M., Wong Y. and Tan K.C.B., HDL dysfunction in type 2 diabetic patients with nephropathy, International Symposium on Healthy Aging, Hong Kong. 2006.

 

Researcher : Siu CWD



List of Research Outputs

 

Siu C.W.D., Jim M.H., Tse H.F., Fan K., Chau M.C. and Chow W.H., Comparison of the efficacy and safety profiles fo intravenuous vitamin K and fresh frozen plasma as treatment of warfarin-related over-anticoagulation in patients with mechanical heart valves, Am J Cardiol. 2006, 97(3): 409-11.

 

Siu C.W.D., Jim M.H., Kung A.W.C., Lau C.P. and Tse H.F., The Outcomes of Thyrotoxicosis Related New-Onset Atrial Fibrillation, JACC. 2006, 47: 10A.

 

Tse H.F., Lam Y.M., Tang M.O., Tsang V.Y.C., Siu C.W.D. and Lau C.P., Avoidance of Left Ventricularof Dyssnchrony Detected by Tissue Doppler Echocardiography by Permanent Right Ventricular Septal Pacing in Patients with High Grade atrioventricular block, JACC. 2006, 47: 23A.

 

Tse H.F., Xue T., Lau C.P., Siu C.W.D., Wang K., Zhang Q.Y., Tomaselli G.F., Akar F.G. and Li R.A., Bioartifical sinus node constructed via in vivo gene transfer of an engineered pacemaker HCN channel reduces the dependence on electronic pacemaker in a sick sinus syndrome model, Circulation. 2006, 114: 1000-1011.

 

Tse H.F., Siu C.W.D., Lee K.L.F., Fan K., Chan H., Tang M.O., Tsang V.Y.C., Lee S.W.L. and Lau C.P., The incremental benefit of rate-adaptive pacing on exercise performance during cardiac resynchronization therapy., J Am Coll Cardiol . 2005, 46(12): 2292-7.

 

Yiu K.H., Siu C.W.D., Lee K.L.F., Lam L., Chan R.H.W., Lee S.W.L., Lau C.P. and Tse H.F., Adverse Clinical Outcomes in Left-sided Infective Endocarditis Complicated Intravenous drug addict, JACC . 2006, 47: 281A.

 

Yiu K.H., Miu R., Lee K.L.F., Yung L.Y., Siu C.W.D., Tse H.F., Lam B., Lam J., Ip M.S.M. and Lau C.P., Improvement of sleep Apnea in heart failure patients after cardiac resynchronization therapy is associated with a significant dop in pulmonary arterial pressure, Heart Rhythm. 2006, 3, No. 5: S87.

 

Yiu K.H., Lee K.L.F., Tse H.F., Siu C.W.D., Lam B., Ip M.S.M. and Lau C.P., Improvement of sleep apnea in heart failure patients after cardiac resynchronization therapy is caused by relief of pulmonary congestion as reflected by a drop of pulmonary arterial pressure, Europace. 2006, 10/6.

 

Yiu K.H., Miu K.M., Lee K.L.F., Tse H.F., Siu C.W.D., Lam K., Lam B., Ip M.S.M. and Lau C.P., Improvement of sleep apnea in heart failure patients after cardiac resynchronization therapy is caused by relief of pulmonary congestion sa reflected by a drop of pulmonary congestion as reflected by a drop of pulmonary arterial pressure, Europace . 2006, 8 Supplement 1: 10/6.

 

Yiu K.H., Siu C.W.D., Lee K.L.F., Lam L., Chan R.H.W., Lee S.W.L., Lau C.P. and Tse H.F., Temporal Trend of Infective Endocarditis in Chinese: A Population Based Study Over 10 Years Period, JACC. 2006, 984-24.

 

Researcher : Sum SM



List of Research Outputs

 

Sum S.M., Wong D.K.H., Yuen J.C.H., Lai C.L. and Yuen R.M.F., Comparison of the COBAS TaqMan HBV Test with the COBAS Amplicor Monitor Test for Measurement of Hepatitis B Virus DNA in Serum, Journal of Medical Virology. 2005, 77: 486-490.

 

Yuan H., Yuen R.M.F., Wong D.K.H., Sum S.M., Sablon E., Ng I.O.L. and Lai C.L., Impact of Precore and Core Promoter Mutations on Hepatic Histology in Patients with Chronic Hepatitis B, Alimentary Pharmacology and Therapeutics. 2005, 22: 301-307.

 

Yuen R.M.F., Tanaka Y., Ng I.O.L., Mizokami M., Yuen J.C.H., Wong D.K.H., Yuan H., Sum S.M., Chan O.O. and Lai C.L., Hepatic necroinflammation and fibrosis in patients with genotypes Ba and C, core-promoter and precore mutations, Journal of Viral Hepatitis . 2005, 12(5): 513-8.

 

Researcher : Sun H



List of Research Outputs

 

Deng X., Sun H., Lau C.P. and Li G.R., Modulation of voltage-gated delayed rectifier potassium channels by EGFR-mediated kinase and relation to cell proliferation in mesenchymal stem cells from rat bone marrow, 11th Medical Research Conference, The University of Hong Kong/Queen Mary Hospital . 2006.

 

Li G.R., Deng X., Sun H., Chung S.S.M., Tse H.F. and Lau C.P., Ion channels in mesenchymal stem cells from rat bone marrow. , Stem Cells. 2006, 24: 1519-1528.

 

Researcher : Sun JZ



List of Research Outputs

 

Kwok R.P., Sun J.Z., Tipoe G.L., Leung Y.H., Yan C.P.K., Ooi C.G.C., Ho P.L., Mak J.C.W., Lam W.K. and Tsang K.W.T., Pseudomonas aeruginosa pyocyanin : discruption of ultrastructure of human respiratory mucosa in vitro, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong,. 2006, Abstract Book 087: pp. 55.

 

Kwok R.P., Sun J.Z., Tipoe G.L., Leung Y.H., Yan C.P.K., Ooi C.G.C., Ho P.L., Mak J.C.W., Lam W.K. and Tsang K.W.T., Pseudomonas aeruginosa pyocyanin : discruption of ultrastructure of human respiratory mucosa in vitro, Respirology. 2005, 10 (Suppl): A126 (#170).

 

Kwok R.P., Leung Y.H., Sun J.Z., Yan C.P.K., Ooi C.G.C., Ho P.L., Tipoe G.L., Lam W.K. and Tsang K.W.T., The effects of gelomyrtol ForteÒ on human ciliary beat frequency in bronchiectasis subjects in vitro, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2006, Abstract Book 086: pp.54.

 

Kwok R.P., Leung Y.H., Sun J.Z., Yan C.P.K., Ooi C.G.C., Ho P.L., Tipoe G.L., Lam W.K. and Tsang K.W.T., The effects of gelomyrtol forteÒ on human ciliary beat frequency in bronchiectasis subjects in vitro, Respirology. 2005, 10 (Suppl): A126 (#169).

 

Kwok R.P., Leung Y.H., Sun J.Z., Yan C.P.K., Ko K.W., Ooi C.G.C., Ho P.L., Tipoe G.L., Lam W.K. and Tsang K.W.T., The effects of myrtol standardized on human ciliary beat frequency in vitro, European Respiratory Medicine. 2005, 26 (Suppl 49): 100S (#714).

 

Researcher : Sun Y



List of Research Outputs

 

Chan O.O., Chu K.M., Leung S.Y., Huang C., Sun Y., Ko S., Yuen R.M.F., Xia H.H.X., Cho C.H., Hui W.M., Lam S.K., Rashid A. and Wong B.C.Y., Helicobacter pylori Infection, Interleukin 1 Beta Polymorphism and Predisposition to Gastric Cancer Through the Cpg Island Methylation, Gastroenterology. 2006, 130 (4 Suppl 2): A-717.

 

Sun Y., Wang J., Xia H.H.X., Zou B., Lin M.C., Kung H. and Wong B.C.Y., Interferon-β-induced expression of XAF1 requires phosphorylation of STAT1 and a sequential activation of protein kinase C and JNK in colon cancer. Digestive Disease Week 2006, 20-25 May, Los Angeles, USA , Gastroenterology. 2006, 4 Suppl 2: A671.

 

Sun Y., Xia H.H.X., Zhu S., Zou B., Lin M.C., Kung H. and Wong B.C.Y., Novel interaction between xiap-associated factor 1 (XAF1) and nuclear coactivator CBP in colon cancer. Digestive Disease Week 2006, 20-25 May, Los Angeles, USA , Gastroenterology. 2006, 4 Suppl 2: A680.

 

Wang J., Peng Y., Sun Y., He H., Zhu S., An X.M., Li M., Lin M.C., Zou B., Xia H.H.X., Jiang B., Chan O.O., Yuen R.M.F., Kung H.F. and Wong B.C.Y., All-Trans Retinoic Acid Induces XAF1 Expression Through an Interferon Regulatory Factor-1 Element in Colon Cancer, Gastroenterology. 2006, 130(3): 747-758.

 

Xia H.H.X., He H., Wang J., Gu Q., Lin M.C., Zou B., Yu L., Sun Y., Chan O.O., Kung H.F. and Wong B.C.Y., Induction of apoptosis and cell cycle arrest by a specific c-Jun NH(2)-terminal kinase (JNK) inhibitor, SP-600125, in gastrointestinal cancers., Cancer Letters. 2005, 241(2): 268-74.

 

Yung S.S.Y., Tsang R.C.W., Sun Y., Leung J.K.H. and Chan D.T.M., Effect of Human Anti-DNA Antibodies on Proximal Renal Tubular Epithelial Cell Cytokine Expression: Implication on Tubulointerstitial Inflammation in Lupus Nephritis, Journal of the American Society of Nephrology. 2005, 16: 3281-3294.

 

Zou B., Chim J.C.S., Lin M.C., Zeng H., He H., Yu L., Sun Y., Jiang S.H. and Wong B.C.Y., Correlation between the single-site CpG mutation within the gene promoter and the expression silencing of XIAP -Associated Factor 1 (XAF1) in human colon cancer cell lines. Asian Pacific Digestive Week, Sept. 25-28, 2005, Seoul, Korea., Journal of Gastroenterology and Hepatology. 2005, 20: Supp A253.

 

Zou B., Chim J.C.S., Lin M.C., Zeng H., He H., Yu L., Sun Y., Jiang S.H. and Wong B.C.Y., Distinguished Poster Award, "Correlation between the single-site CpG mutation within the gene promoter and the expression silencing of XIAP -Associated Factor 1 (XAF1) in human colon cancer cell lines" , Asian Pacific Digestive Week, Sept. 25-28, Seoul, Korea. 2005.

 

Researcher : Sun Y



List of Research Outputs

 

Chan O.O., Chu K.M., Leung S.Y., Huang C., Sun Y., Ko S., Yuen R.M.F., Xia H.H.X., Cho C.H., Hui W.M., Lam S.K., Rashid A. and Wong B.C.Y., Helicobacter pylori Infection, Interleukin 1 Beta Polymorphism and Predisposition to Gastric Cancer Through the Cpg Island Methylation, Gastroenterology. 2006, 130 (4 Suppl 2): A-717.

 

Sun Y., Wang J., Xia H.H.X., Zou B., Lin M.C., Kung H. and Wong B.C.Y., Interferon-β-induced expression of XAF1 requires phosphorylation of STAT1 and a sequential activation of protein kinase C and JNK in colon cancer. Digestive Disease Week 2006, 20-25 May, Los Angeles, USA , Gastroenterology. 2006, 4 Suppl 2: A671.

 

Sun Y., Xia H.H.X., Zhu S., Zou B., Lin M.C., Kung H. and Wong B.C.Y., Novel interaction between xiap-associated factor 1 (XAF1) and nuclear coactivator CBP in colon cancer. Digestive Disease Week 2006, 20-25 May, Los Angeles, USA , Gastroenterology. 2006, 4 Suppl 2: A680.

 

Wang J., Peng Y., Sun Y., He H., Zhu S., An X.M., Li M., Lin M.C., Zou B., Xia H.H.X., Jiang B., Chan O.O., Yuen R.M.F., Kung H.F. and Wong B.C.Y., All-Trans Retinoic Acid Induces XAF1 Expression Through an Interferon Regulatory Factor-1 Element in Colon Cancer, Gastroenterology. 2006, 130(3): 747-758.

 

Xia H.H.X., He H., Wang J., Gu Q., Lin M.C., Zou B., Yu L., Sun Y., Chan O.O., Kung H.F. and Wong B.C.Y., Induction of apoptosis and cell cycle arrest by a specific c-Jun NH(2)-terminal kinase (JNK) inhibitor, SP-600125, in gastrointestinal cancers., Cancer Letters. 2005, 241(2): 268-74.

 

Yung S.S.Y., Tsang R.C.W., Sun Y., Leung J.K.H. and Chan D.T.M., Effect of Human Anti-DNA Antibodies on Proximal Renal Tubular Epithelial Cell Cytokine Expression: Implication on Tubulointerstitial Inflammation in Lupus Nephritis, Journal of the American Society of Nephrology. 2005, 16: 3281-3294.

 

Zou B., Chim J.C.S., Lin M.C., Zeng H., He H., Yu L., Sun Y., Jiang S.H. and Wong B.C.Y., Correlation between the single-site CpG mutation within the gene promoter and the expression silencing of XIAP -Associated Factor 1 (XAF1) in human colon cancer cell lines. Asian Pacific Digestive Week, Sept. 25-28, 2005, Seoul, Korea., Journal of Gastroenterology and Hepatology. 2005, 20: Supp A253.

 

Zou B., Chim J.C.S., Lin M.C., Zeng H., He H., Yu L., Sun Y., Jiang S.H. and Wong B.C.Y., Distinguished Poster Award, "Correlation between the single-site CpG mutation within the gene promoter and the expression silencing of XIAP -Associated Factor 1 (XAF1) in human colon cancer cell lines" , Asian Pacific Digestive Week, Sept. 25-28, Seoul, Korea. 2005.

 

Researcher : Tam S



List of Research Outputs

 

Cheung E.Y.N., Ho A.Y.Y., Lam K.F., Tam S. and Kung A.W.C., Determinants of bone mineral density in Chinese men, Osteoporosis International. Springer London, 2005, 16: 1481-1486.

 

Lee K.K., Shiu S.W.M., Wong Y., Wong W.K. and Tam S., Plasma apolipoprotein E is a major determinant of phospholipid transfer protein activity in type 2 diabetes mellitus, The 6th International Diabetes Federation Western Pacific Region Congress, Bangkok, Oct 2005.

 

Tan K.C.B., Chow W.S., Lam J.C.M., Lam B., Wong W.K., Tam S. and Ip M.S.M., HDL dysfunction in obstructive sleep apnea, Atherosclerosis. 2006, 184(2): 377-82.

 

Tan K.C.B., Shiu S.W.M., Wong Y., Wong W.K. and Tam S., Plasma apolipoprotein E concentration is an important determinant of phospholipid transfer protein activiity in type 2 diabetes mellitus, Diabetes Metab Res Rev. 2006.

 

Tso A.W.K., Wat N.M.S., Xu A., Tam S., Fong H.Y., Janus E.D., Tan K.C.B. and Lam K.S.L., Adiponectin/C-reactive protein ratio is an independent surrogate marker predictive of the development of metabolic risks and the metabolic syndrome over 5 years in Chinese, The 6th International Diabetes Federation Western Pacific Region Congress, Bangkok, Oct 2005.

 

Xu A., Wang Y., Xu J., Stejskal D., Tam S., Zhang J., Wat N.M.S., Wong W.K. and Lam K.S.L., Adipocyte fatty acid-binding protein is a plasma biomarker closely associated with obesity and metabolic syndrome, Clinical Chemistry. 2006, 52: 405-413.

 

Researcher : Tam TC



List of Research Outputs

 

Tam T.C., Chan K.Y., Ho S.L., Luk J.K.H. and Chu L.W., Herpetic shoulder paresis in a Chinese elderly patient., Hong Kong Medical Journal. 2005, 11: 399-402.

 

Researcher : Tan KCB



Project Title:

Advanced glycation end products and diabetic complications

Investigator(s):

Tan KCB, Betteridge J.

Department:

Medicine

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

12/2002

 

Abstract:

Hyperglycaemia leading to the increased formation and accumulation of advanced glycation end products (AGEs) has been implicated in causing many of the complications of diabetes. In this project, the research team plan to explore the underlying mechanisms whereby AGEs may cause defective endothelium-dependent vasodilation.

 

Project Title:

Effects of adiponectin on endothelial cell function

Investigator(s):

Tan KCB, Lam KSL, Xu A

Department:

Medicine

Source(s) of Funding:

Small Project Funding

Start Date:

11/2003

Completion Date:

10/2005

 

Abstract:

To investigate whether adiponectin increases NO production by inducing eNOS expression and activity; to determine whether adiponectin phosphorylates eNOS through Akt activation.

 

Project Title:

Endothelial lipase activity in diabetes

Investigator(s):

Tan KCB

Department:

Medicine

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

Completion Date:

10/2006

 

Abstract:

To determine whether the expression of EL is increased in diabetes; to investigate the regulation of EL in vitro.

 

Project Title:

HDL dysfunction and diabetes mellitus

Investigator(s):

Tan KCB

Department:

Medicine

Source(s) of Funding:

Small Project Funding

Start Date:

12/2005

 

Abstract:

Background Epidemiological studies have shown that plasma HDL cholesterol levels are strongly inversely associated with cardiovascular disease and HDL is thought to play a protective role against atherosclerosis. The antiatherogenic properties of HDL include promotion of cellular cholesterol efflux and reverse cholesterol transport, as well as antioxidant, anti-inflammatory and anticoagulant properties (1). In addition to promoting efflux of excess cholesterol from cells in the arterial wall and returning cholesterol to the liver for excretion into the bile, HDL inhibits lipid oxidation, reduces the inflammatory response of endothelial cells, promotes the availability of nitric oxide, and inhibits the coagulation pathway. The magnitude of these protective effects of HDL are determined not only by its circulating levels, but also in part by the qualitative function of the HDL species (1,2), and compositional changes in HDL can result in a loss of many of its antiatherogenic properties (3). Functional assays have recently been developed to determine the antiatherogenic profile of an individual’s HDL by measuring the ability of HDL to inactivate and/or to prevent the formation of oxidized lipids (4). HDL dysfunction has been reported in subjects with coronary heart disease (5) and we have recently demonstrated HDL dysfunction in subjects with obstructive sleep apnoea (6). Problems to be addressed and objectives: Patients with type 2 diabetes mellitus frequently have low HDL cholesterol levels and studies involving small number of diabetic subjects have suggested that HDL is dysfunctional in diabetes mellitus. Gowri et al showed that HDL2 exhibited decreased protection against THP1 macrophage-mediated LDL oxidation in 10 poorly controlled type 2 diabetic patients (7), whereas Nobecourt et al reported that it was the antioxidative activity of small dense HDL3 (and not HDL2) that was deficient in 20 well-controlled type 2 diabetic patients (8). What accounts for the observed differences between these studies is not clear and whether HDL dysfunction is related to glycaemic control and/or to the presence of diabetic complications has not been investigated. Functional abnormalities in HDL have also been described in non-diabetic patients with chronic kidney disease (9). Hence, the objectives of this study are (i) to determine whether HDL dysfunction is related to the presence of diabetic nephropathy (both incipient and overt) and its association with the degree of albuminuria. If HDL dysfunction is found to relate to the severity of diabetic nephropathy, does HDL dysfunction improve when diabetic nephropathy is being treated with agents that block the renin-angiotensin system? (ii) Is HDL dysfunction more severe in poorly controlled type 2 diabetic patients? Can it be reversed by improving glycaemic control and is HDL dysfunction due to abnormalities in the intrinsic physicochemical properties of HDL and/or to changes in HDL associated enzymes such as paraoxonase and platelet-activating factor acetylhydrolase which are involved in catalyzing the breakdown of oxidized phospholipids? References: 1) Wang M, Briggs MR. HDL: The metabolism, function, and the therapeutic importance. Chem Rev 2004;104:119-37 2) Rohrer L, Hersberger M, von Eckardstein A. High density lipoproteins in the intersection of diabetes mellitus, inflammation and cardiovascular disease. Curr Opin Lipidol. 2004;15:269-78. 3) Van Lenten BJ, Hama SY, de Beer FC et al. Anti-inflammatory HDL becomes pro-inflammatory during the acute phase response. Loss of protective effect of HDL against LDL oxidation in aortic wall cell cocultures. J Clin Invest. 1995;96:2758-67. 4) Navab M, Hama SY, Hough GP et al. A cell-free assay for detecting HDL that is dysfunctional in preventing the formation of or inactivating oxidized phospholipids. J Lipid Res. 2001;42:1308-17. 5) Ansell BJ, Navab M, Hama S et al. Inflammatory/antiinflammatory properties of high-density lipoprotein distinguish patients from control subjects better than high-density lipoprotein cholesterol levels and are favorably affected by simvastatin treatment. Circulation. 2003;108:2751-6. 6) Tan KCB, Chow WS, Lam JCM et al. HDL dysfunction in obstructive sleep apnea. Atherosclerosis, in press. 7) Gowri MS, Van der Westhuyzen DR, Bridges SR, Anderson JW. Decreased protection by HDL from porly controlled type 2 diabetic subjects against LDL oxidation may be due to the abnormal composition of HDL. Arterioscler Thromb Vasc Biol. 1999;19:2226-2233. 8) Nobecourt E, Jacqueminet S, Hansel B et al. Defective antioxidative activity of small dense HDL3 particles in type 2 diabetes: relationship to elevated oxidative stress and hyperglycaemia. Diabetologia. 2005;48:529-538. 9) Kaysen GA, Eiserich JP. The role of oxidative stress-altered lipoprotein structure and function and microinflammation on cardiovascular risk in patients with minor renal dysfunction, J Am Soc Nephrol 2004;15:538-548.

 

Project Title:

Glycosidized LDL and atherosclerosis

Investigator(s):

Tan KCB

Department:

Medicine

Source(s) of Funding:

Merit Award for RGC CERG Funded Projects

Start Date:

12/2005

 

Abstract:

N/A

 

Project Title:

Glycosidized LDL and atherosclerosis

Investigator(s):

Tan KCB, Tam S, Bucala RJ

Department:

Medicine

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

12/2005

 

Abstract:

To investigate the effects of glycosidized LDL on foam cell formation and reverse cholesterol transport; to evaluate glycosidized LDL as an inflammatory stimulus; to test clinical strategies to lower glycosidized LDL.

 

List of Research Outputs

 

Chow W.S., Tan K.C.B., Lam J.C.M., Lam B., Bucala R., Betteridge D.J. and Ip M.S.M., Advanced glycation end products are increased in non-diabetic patients with obstructive sleep apnea but to a lesser degree than type 2 diabetic patients, 11th Medical Research Conference of Department of Medicine, HKU. 2006.

 

Kwong Y.L., Lau W.C.S., Ho S.L., Epstein R., Young R.T.T., Chan H.H.L., Tse H.F., Lam L., Chen W.H., Lee K.L.F., Ip M.S.M., Tsang K.W.T., Lam B., Tang S.C.W., Chan R.H.W., Lee S.W.L., Tan K.C.B., Yeung C.K., Chan D.T.M., Wong R.W.S., Choy C.B.Y., Wong B.C.Y., Li F.K., Lo W.K., Lui S.L., Cheung R.T.F., Mak W., Ho J.C.M., Mok T.M.Y., Kung A.W.C., Cheung B.M.Y., Chow W.S., Yuen R.M.F. and Wat N.M.S., In: Lau CP, Kumana CR, Lai CL, Lai KN, Lam KSL, Lam WK, Problem-Based Medical Case Management. Hong Kong, Hong Kong University Press, 2005.

 

Tan K.C.B., 5th Scientific Conference on Cardiovascular Sciences across the Strait, Dec 2005, Hong Kong, Prevention of Cardiovascular Disease in Diabetes. 2005.

 

Tan K.C.B., 7th Symposium on Molecular Diabetology in Asia, Dec 2005, Hong Kong, Metabolic and inflammatory determinants of endothelial dysfunction. 2005.

 

Tan K.C.B., Chow W.S., Lam J.C.M., Lam B., Bucala R., Betteridge D.J. and Ip M.S.M., Advanced glycation end products are increased in non-diabetic patients with obstructive sleep apnea but to a lesser degree than type 2 diabetic patients, 41st European Association for the Study of Diabetes Annual Meeting, Athens, Sept 2005.

 

Tan K.C.B., Chow W.S., Lam J.C.M., Lam B., Bucala R., Betteridge D.J. and Ip M.S.M., Advanced glycation end products in non-diabetic patients with obstructive sleep apnea, Sleep . 2006, 29: 329-33.

 

Tan K.C.B., Can cardiovascular disease be prevented in diabetes?, Med Progress. 2005, 32: 435-8.

 

Tan K.C.B., Certificate Course on Update on Diabetes Management, Nov 2005, Hong Kong, Update on Management of Diabetic Dyslipidaemia. 2005.

 

Tan K.C.B., Chairman of symposium "Cardiovascular complications in diabetes", The 5th Sciencific Conference on Cardiovascular Science Across the Strait, Hong Kong, Dec 2005. 2005.

 

Tan K.C.B., Chairman of symposium "Hong Kong Atheroslcerosis Society Symposium", The 7th Hong Kong Diabetes and Cardiovascular Risk Factors - East Meets West Symposium, Hong Kong, Oct 2005. 2005.

 

Tan K.C.B., Chairman of symposium "Past, present and future of diabetes in Hong Kong", ABC Series of Symposia on Diabetes, Hong Kong, Nov 2005. 2005.

 

Tan K.C.B., Chapter 3: Endocrinology short cases, In: Lau CP, Chen MZ, Kumana CR, Lai CL, Lai KN, Lam KSL and Lam WK (Eds), Problem-Based Medical Case Management. Hong Kong, Hong Kong University Press, 2005, pp45 - 61.

 

Tan K.C.B., Chapter 4: Endocrinology long cases, In: Lau CP, Chen MZ, Kumana CR, Lai CL, Lai KN, Lam KSL and Lam WK (Eds), Problem-Based Medical Case Management. Hong Kong University Press, 2005, 63-71.

 

Tan K.C.B., Chariman of Symposium, "hsCRP: marker or mediator of cardiovascular risk?", Hong Kong, Sept 2005. 2005.

 

Tan K.C.B., Co-Chairman of the Scientific Committe, The 4th International Huaxia Congress of Endocrinology, Dec 2006. 2005.

 

Tan K.C.B., Definition, classification and diagnosis of diabetes and other dysglycemia categories, Diabetes Hongkong 2005 Position Statements on Diabetes Management. 2005.

 

Tan K.C.B., Diabetes Care Guideline Statement: Difinition, classification and diagnosis of diabetes and other dysglycemia categories, 2005.

 

Tan K.C.B., Chow W.S., Lam J.C.M., Lam B., Wong W.K., Tam S. and Ip M.S.M., HDL dysfunction in obstructive sleep apnea, Atherosclerosis. 2006, 184(2): 377-82.

 

Tan K.C.B., Chow W.S., Shiu S.W.M., Bucala R. and Betteridge D.J., Increased serum level of soluble receptor for advanced glycation end products in type 2 diabetic patients with nephropathy, International Symposium on Healthy Aging, Hong Kong. 2006.

 

Tan K.C.B., Member of the Organising Committee, The 4th International Huaxia Congress of Endocrinology, Dec 2006. 2005.

 

Tan K.C.B., Metabolic and inflammatory determinants of endothelial dysfunction, The 7th Symposium on Molecular Diabetology in Asia, Hong Kong, Dec 2005. 2005.

 

Tan K.C.B., Pharmacological intervention of diabetic dyslipidaemia, Post-registration Course in Daibetes Nursing, Hong Kong, Sept 2005. 2005.

 

Tan K.C.B., Shiu S.W.M., Wong Y., Wong W.K. and Tam S., Plasma apolipoprotein E concentration is an important determinant of phospholipid transfer protein activiity in type 2 diabetes mellitus, Diabetes Metab Res Rev. 2006.

 

Tan K.C.B., Post-registration Course in Diabetes Nursing, Sept 2005, Hong Kong, Pharmacological Intervention for Diabetes. 2005.

 

Tan K.C.B., Prevention of cardiovascular disease in diabetes, The 5th Scientific Conference on Cardiovascular Sciences Across the Strait, Hong Kong, Dec 2005. 2005.

 

Tan K.C.B., Reviewer, Diabetic Medicine. 2006.

 

Tan K.C.B., Reviewer, Atheroscleorsis. 2006.

 

Tan K.C.B., Reviewer, Britiah Journal of Clinical Pharmacology. 2006.

 

Tan K.C.B., Reviewer, Circulation. 2006.

 

Tan K.C.B., Reviewer, Clinical Chemistry. 2006.

 

Tan K.C.B., Reviewer, Diabetes. 2006.

 

Tan K.C.B., Reviewer, Diabetes Care. 2006.

 

Tan K.C.B., Reviewer, Diabetes Research and Clinical Practice. 2006.

 

Tan K.C.B., Reviewer, Diabetes, Obesity and Metabolism. 2006.

 

Tan K.C.B., Reviewer, Hong Kong Medcial Journal. 2006.

 

Tan K.C.B., Reviewer, Hong Kong Practitioner. 2006.

 

Tan K.C.B., Reviewer, Journal of American Medical Association (South East Asia). 2006.

 

Tan K.C.B., Reviewer, Journal of Clincial Endocrinology and Metabolism. 2006.

 

Tan K.C.B., Reviewer, Medical Progress. 2006.

 

Tan K.C.B., Reviewer, QJM - An International Journal of Medicine. 2006.

 

Tan K.C.B., Chow W.S., Shiu S.W.M., Bucala R. and Betteridge D.J., Serum level of soluble receptor for advanced glcyation end products is associated with circulating advanced glycation end products in type 2 diabetes, XIV International Symposium on Atherosclerosis, Rome. 2006.

 

Tan K.C.B., Update on cardiovascular disease in diabetes, Certificate Course on Update on Diabetes Management, Hong Kong, Nov 2005. 2005.

 

Tan K.C.B., 糖尿病併發症及其預防方法, In: 蔡祥熙、簡靜兒(Eds), 糖糖正正-正確正視糖尿病, 香港內分泌學會、明窗出版社, 2005.

 

Tso A.W.K., Wat N.M.S., Xu A., Tam S., Fong H.Y., Janus E.D., Tan K.C.B. and Lam K.S.L., Adiponectin/C-reactive protein ratio is an independent surrogate marker predictive of the development of metabolic risks and the metabolic syndrome over 5 years in Chinese, The 6th International Diabetes Federation Western Pacific Region Congress, Bangkok, Oct 2005.

 

Zhou H., Shiu S.W.M., Wong Y. and Tan K.C.B., Association between advanced glycation end products and reduced activity of HDL to protect LDL against oxidation in type 2 diabetes mellitus, American Diabetes Association 66th Scientific Sessions, Washington. 2006.

 

Zhou H., Tan K.C.B., Chow W.S., Bucala R. and Betteridge D.J., Association between advanced glycation end products and serum cholesterol efflux capacity in type 2 diabetes mellitus, The 6th International Diabetes Federation Western Pacific Region Congress, Bangkok, Oct 2005.

 

Zhou H., Shiu S.W.M., Wong Y. and Tan K.C.B., Decreased activity of HDL to protect LDL against oxidation in type 2 diabetic patients with nephropathy, 5th Congress of Asian Pacific Society of Atherosclerosis and Vascular Diseases. 2006.

 

Zhou H., Shiu S.W.M., Wong Y. and Tan K.C.B., HDL dysfunction in type 2 diabetic patients with nephropathy, International Symposium on Healthy Aging, Hong Kong. 2006.

 

Researcher : Tang CSO



List of Research Outputs

 

Lam M.F., Leung J.C.K., Tang C.S.O., Lo W.K., Tse K.C., Yip T.P.S., Lui S.L., Chan D.T.M. and Lai K.N., Mannose binding lectin level and polymorphism in patients on long-term peritoneal dialysis, Nephrology Dialysis Transplantation. 2005, 20: 2489-2496.

 

Tang S., Lai F.M., Lui R.Y.H., Tang C.S.O., Kung N.N.S., Ho Y.W., Chan K.W., Leung J.C.K. and Lai K.N., Lamivudine in hepatitis B-associated membranous nephropathy, Joint symposium on extracorporeal support for multi-organ failure organized by Hong Kong College of Physicians Scientific Symposium and Hong Kong Society of Nephrology Annual Scientific Meeting, 10-11 September 2005, Hong Kong. 2005.

 

Tang S.C.W., Lai F.M., Lui Y.H., Tang C.S.O., Kung N.N., Ho Y.W., Chan K.W., Leung J.C.K. and Lai K.N., Lamivudine in hepatitis B-associated membranous nephropathy, Kidney International. 2005, 68(4): 1750-1758.

 

Tang S.C.W., Leung J.C.K., Chan L.Y., Lui Y.H., Tang C.S.O., Kan C.H., Ho Y.W. and Lai K.N., Mycophenolate mofetil alleviates persistent proteinuria in IgA nephropathy, Kidney International. 2005, 68(2): 802-812.

 

Tse K.C., Tang S.C.W., Tang C.S.O., Lai K.N., Li F.K. and Chan D.T.M., Angiotensin inhibition or blockade for the treatment of patients with quiescent lupus nephritis and persistent proteinuria, Lupus. 2005, 14(12): 947-952.

 

Tse K.C., Tang C.S.O., Lio W.I., Lam M.F. and Chan D.T.M., Quality of life comparison between corticosteroid-and-mycofenolate mofetil and corticosteroid-and-oral cyclophosphamide in the treatment of severe lupus nephritis, Lupus. 2006, 15(6): 371-379.

 

Researcher : Tang CW


Project Title:

Regulation of albumin-induced chemokine expression in human proximal tubular epithelial cells by angiotensin antagonists and HMG-CoA reductase inhibitors

Investigator(s):

Tang SCW

Department:

Medicine

Source(s) of Funding:

Merit Award for RGC CERG Funded Projects

Start Date:

01/2005

 

Abstract:

N/A

 

Project Title:

Regulation of albumin-induced chemokine expression in human proximal tubular epithelial cells by angiotensin antagonists and HMG-CoA reductase inhibitors

Investigator(s):

Tang SCW

Department:

Medicine

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

01/2005

 

Abstract:

To explore in vitro the effect of ACEI, ARB, and statins, either singly or in combination, on albumin-induced expression of IL-8, MCP-1 RANTES, and MIF incultured human PTEC; to dissect the intracellular signal transduction pathway governing the anti-inflammatory effects of these pharmacological agents; to investigate the I>in vitro impact of applying combined a ngiotensin II b blockade and statin treatment on enphrotic mice.

 

List of Research Outputs

 

Researcher : Tang MO



List of Research Outputs

 

Tse H.F., Lam Y.M., Tang M.O., Tsang V.Y.C., Siu C.W.D. and Lau C.P., Avoidance of Left Ventricularof Dyssnchrony Detected by Tissue Doppler Echocardiography by Permanent Right Ventricular Septal Pacing in Patients with High Grade atrioventricular block, JACC. 2006, 47: 23A.

 

Tse H.F., Siu C.W.D., Lee K.L.F., Fan K., Chan H., Tang M.O., Tsang V.Y.C., Lee S.W.L. and Lau C.P., The incremental benefit of rate-adaptive pacing on exercise performance during cardiac resynchronization therapy., J Am Coll Cardiol . 2005, 46(12): 2292-7.

 

Researcher : Tang S



List of Research Outputs

 

Tang S., Lai F.M., Lui R.Y.H., Tang C.S.O., Kung N.N.S., Ho Y.W., Chan K.W., Leung J.C.K. and Lai K.N., Lamivudine in hepatitis B-associated membranous nephropathy, Joint symposium on extracorporeal support for multi-organ failure organized by Hong Kong College of Physicians Scientific Symposium and Hong Kong Society of Nephrology Annual Scientific Meeting, 10-11 September 2005, Hong Kong. 2005.

 

Researcher : Tang SCW



Project Title:

Regulation of albumin-induced chemokine expression in human proximal tubular epithelial cells by angiotensin antagonists and HMG-CoA reductase inhibitors

Investigator(s):

Tang SCW

Department:

Medicine

Source(s) of Funding:

Merit Award for RGC CERG Funded Projects

Start Date:

01/2005

 

Abstract:

N/A

 

Project Title:

Regulation of albumin-induced chemokine expression in human proximal tubular epithelial cells by angiotensin antagonists and HMG-CoA reductase inhibitors

Investigator(s):

Tang SCW

Department:

Medicine

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

01/2005

 

Abstract:

To explore in vitro the effect of ACEI, ARB, and statins, either singly or in combination, on albumin-induced expression of IL-8, MCP-1 RANTES, and MIF incultured human PTEC; to dissect the intracellular signal transduction pathway governing the anti-inflammatory effects of these pharmacological agents; to investigate the I>in vitro impact of applying combined a ngiotensin II b blockade and statin treatment on enphrotic mice.

 

List of Research Outputs

 

Chan K.W., Chan G.S.W. and Tang S.C.W., Glomerular pathology of allograft kidneys in Hong Kong , Transplantation Proceedings. 2005, 37(10): 4293-6.

 

Chan L.Y., Leung J.C.K., Tang S.C.W. and Lai K.N., Glucose modulates leptin and adiponectin synthesis by human peritoneal omental adipocyte, Journal of American Society of Nephrology. 2005, 16: 791A.

 

Chan L.Y., Leung J.C.K., Tang S.C.W., Choy C.B.Y. and Lai K.N., Tubular expression of angiotensin II receptors and their regulation in IgA nephropathy, Journal of American Society of Nephrology. 2005, 16(8): 2306-2317.

 

Kwong Y.L., Lau W.C.S., Ho S.L., Epstein R., Young R.T.T., Chan H.H.L., Tse H.F., Lam L., Chen W.H., Lee K.L.F., Ip M.S.M., Tsang K.W.T., Lam B., Tang S.C.W., Chan R.H.W., Lee S.W.L., Tan K.C.B., Yeung C.K., Chan D.T.M., Wong R.W.S., Choy C.B.Y., Wong B.C.Y., Li F.K., Lo W.K., Lui S.L., Cheung R.T.F., Mak W., Ho J.C.M., Mok T.M.Y., Kung A.W.C., Cheung B.M.Y., Chow W.S., Yuen R.M.F. and Wat N.M.S., In: Lau CP, Kumana CR, Lai CL, Lai KN, Lam KSL, Lam WK, Problem-Based Medical Case Management. Hong Kong, Hong Kong University Press, 2005.

 

Lai K.N., Chan L.Y., Tang S.C.W. and Leung J.C.K., Ganoderma extract prevents albumin-induced oxidative damage and chemokines synthesis in cultured human proximal tubular epithelial cells, Nephrology Dialysis Transplantation. 2006, 21(5): 1188-1197.

 

Lai K.N., Tang S.C.W., Chan L.Y. and Leung J.C.K., Monocytes/T cells modulate chemokine release and chemokine receptor expression in proximal tubular epithelial cells in proteinuric state, Journal of American Society of Nephrology. 2005, 16: 642A.

 

Lam J.C.M., Lam B., Tang S.C.W. and Ip M.S.M., A sleep study with positional hypoxemia, Sleep Medicine. 2006, 7: 383-384.

 

Leung J.C.K., Chan L.Y., Li F.K., Tang S.C.W., Chan K.W., Chan D.T.M., Lam M.F., Wieslander A. and Lai K.N., Glucose degradation products downregulate ZO-1 expression in human peritoneal mesothelial cells: the role of VEGF, Nephrology Dialysis Transplantation. 2005, 20(7): 1336-1349.

 

Leung J.C.K., Chan L.Y., Tang S.C.W. and Lai K.N., Glycosylation profile of anionic polymeric IgA and their binding characteristics to cultured mesangial cells in IgA nephropathy, Journal of American Society of Nephrology. 2005, 16: 49A.

 

Leung J.C.K., Chan Y.Y., Tang S.C.W., Chu K.M. and Lai K.N., Leptin induces TGF-b synthesis through functional leptin receptor expressed by human peritoneal meoshtelial cell, Kidney International. 2006, 69: 2078-2086.

 

Tang S.C.W., Leung J.C.K., Chan L.Y., Tsang W.L. and Lai K.N., Activation of tubular epithelial cells in diabetic nephropathy and the role of the peroxisome proliferator-activated receptor-gamma agonist, Journal of American Society of Nephrology. 2006, 17(6): 1633-1643.

 

Tang S.C.W. and Lai K.N., Chapter : "Glomerulonephritis", In: T.M. Chan and M.K. Chan, Integrated Systemic Nephrology, 3rd Edition. Hong Kong, The University of Hong Kong, 2006, 63-70.

 

Tang S.C.W. and Lai K.N., Chapter : "Hypertension and the kidney", In: T.M. Chan and M.K. Chan, Integrated Systemic Nephrology, 3rd Edition. Hong Kong, The University of Hong Kong, 2006, 93-102.

 

Tang S.C.W. and Lai K.N., Chapter : "Some specific glomerulonephritides", In: T.M. Chan and M.K. Chan, Integrated Systemic Nephrology, 3rd Edition. Hong Kong, The University of Hong Kong, 2006, 71-80.

 

Tang S.C.W., Lam B., Leung H., Ip M.S.M. and Lai K.N., Impact of nocturnal peritoneal dialysis on the severity of sleep apnoea and the duration of hypoxemia during sleep: A cross-over study, Journal of American Society of Nephrology. 2005, 16: 852A.

 

Tang S.C.W., Lai F.M., Lui Y.H., Tang C.S.O., Kung N.N., Ho Y.W., Chan K.W., Leung J.C.K. and Lai K.N., Lamivudine in hepatitis B-associated membranous nephropathy, Kidney International. 2005, 68(4): 1750-1758.

 

Tang S.C.W., Leung J.C.K., Chan L.Y., Lui Y.H., Tang C.S.O., Kan C.H., Ho Y.W. and Lai K.N., Mycophenolate mofetil alleviates persistent proteinuria in IgA nephropathy, Kidney International. 2005, 68(2): 802-812.

 

Tang S.C.W., Ho Y.W., Leung J.C.K. and Lai K.N., Mycophenolate mofetil in the treatment of steroid-resistant primary focal segmental glomerulosclerosis, Journal of Nephrology. 2005, 18(4): 429-432.

 

Tang S.C.W., Leung J.C.K., Chan L.Y., Tsang W.L. and Lai K.N., Role of PPAR-g agonist in diabetic nephropathy: An in vivo study, Journal of American Society of Nephrology. 2005, 16: 613A.

 

Tang S.C.W., Ho Y.W., Chan C.S. and Lai K.N., Rupture of the left kidney, American Journal of Kidney Diseases. 2006, 47(2): A31, e21-2.

 

Tse K.C., Tang S.C.W., Tang C.S.O., Lai K.N., Li F.K. and Chan D.T.M., Angiotensin inhibition or blockade for the treatment of patients with quiescent lupus nephritis and persistent proteinuria, Lupus. 2005, 14(12): 947-952.

 

Yip T.P.S., Tse K.C., Lam M.F., Tang S.C.W., Li F.K., Choy C.B.Y., Lui S.L., Chan D.T.M., Lai K.N. and Lo W.K., Risk factors and outcomes of extended-spectrum beta-lactamase-producing E. coli peritonitis in CAPD patients, Peritoneal Dialysis International. 2006, 26(2): 191-197.

 

Researcher : Tao R



List of Research Outputs

 

Tao R., Lau C.P. and Li G.R., Functional ion channel expression in mouse bone marrow derived mesenchymal stem cells, Journal of Hong Kong College Cardiology/The 9th Institute of Cardiovascular Science and Medicine & the 5th Scientific Conference on Cardiovascular Science Across the Strait. 2005, 13:120-OP94.

 

Tao R., Lau C.P. and Li G.R., InsP3 receptor-mediated calcium oscillation regulates proliferation and differentiation of human mesenchymal stem cells from bone marrow, 11th Medical Research Conference, The University of Hong Kong/Queen Mary Hospital. 2006.

 

Tao R., Lau C.P. and Li G.R., Ion channels in mouse bone marrow derived mesenchymal stem cells, 10th Research Postgraduate Symposium, Faculty of Medicine, HKU. 2005.

 

Researcher : Tian M



List of Research Outputs

 

Tian M., Dong M., Chiu S.W., Lau C.P. and Li G.R., Effects of the antifungal antibiotic clotrimazole on human cardiac repolarization potassium currents. , British Journal of Pharmacology. 2006, 147: 289-297.

 

Researcher : Tong SM



List of Research Outputs

 

Chan O.O., Jim M.H., Lam K.F., Siu D.C.W., Tong S.M., Ng F.H., Hui W.M., Chan C.K., Lai K.C., Hu H.C., Yuen R.M.F., Lau Y.K., Lee S.W.L., Lam S.K. and Wong B.C.Y., Patients with Coronary Artery Disease are at High Risk for Developing Colorectal Cancer and Adenoma: An Interim Analysis of a Prospective Study, Gastroenterology. 2006, 130 (4 Supp 2): A-36.

 

Wong W.M.R., Gu Q., Chu K.M., Yee Y.K., Fung F.M.Y., Tong S.M., Chan O.O.A., Lai K.C., Chan C.K. and Wong B.C.Y., Lansoprazole, levofloxacin and amoxicillin triple therapy versus quadruple therapy as second-line treatment of resistant Helicobacter pylori infection, Alimentary Pharmacology & Therapeutics. 2006, 23: 421-427.

 

Researcher : Tsang KWT



Project Title:

Could gastro-oesphageal reflux be a cause of continued airway damage in bronchiectasis?

Investigator(s):

Tsang KWT, Hu W.

Department:

Medicine

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

11/2002

 

Abstract:

The study is to determine the prevalence and severity of gastro-oesophageal reflux (GOR) in patients with bronchiectasis, the relationship of GOR with airway inflammation parameters, and identify clinical an dother parameters which predict the presence of GOR in patients with bronchiectasis with and without upper abdominal symptoms.

 

List of Research Outputs

 

Ho J.C.M., Mak J.C.W., Ho S., Ip M.S.M., Tsang K.W.T., Lam W.K. and Chan M.M.W., Manganese superoxide dismutase and catalase genetic polymorphisms, activity levels and lung cancer risk in Chinese in Hong Kong. 11th World Conference on Lung Cancer , Lung Cancer. 2005, 49(Suppl 2): S191.

 

Ho J.C.M., Tsang K.W.T. and Lam W.K., Respiratory Medicine-Long Cases , in CP Lau (eds), Problem-based medical case mangement. Hong Kong, Hong Kong University Press, 2006, 215-230.

 

Ho J.C.M., Tsang K.W.T. and Lam W.K., Respiratory Medicine-Short Cases , in CP Lau (eds), Problem-based medical case management. Hong Kong, Hong Kong University Press, 2006, 193-214.

 

Ho P.L., Chau P.H., Yip P.S.F., Ooi C.G.C., Khong P.L., Ho J.C.M., Wong P.C., Ko C.F., Yan C.P.K. and Tsang K.W.T., A prediction rule for clinical diagnosis of severe acute respiratory syndrome, European Respiratory Journal. 2005, 26(3): 474-9.

 

Ho P.L., Que T.L., Ng T.K., Chiu S.S.S., Yung R.W.H. and Tsang K.W.T., Clinical outcomes of bacteremic pneumococcal infections in an area with high resistance, European Journal of Clinical Microbiology and Infectious Diseases. 2006, 25(5): 323-7.

 

Kwok R.P., Sun J.Z., Tipoe G.L., Leung Y.H., Yan C.P.K., Ooi C.G.C., Ho P.L., Mak J.C.W., Lam W.K. and Tsang K.W.T., Pseudomonas aeruginosa pyocyanin : discruption of ultrastructure of human respiratory mucosa in vitro, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong,. 2006, Abstract Book 087: pp. 55.

 

Kwok R.P., Sun J.Z., Tipoe G.L., Leung Y.H., Yan C.P.K., Ooi C.G.C., Ho P.L., Mak J.C.W., Lam W.K. and Tsang K.W.T., Pseudomonas aeruginosa pyocyanin : discruption of ultrastructure of human respiratory mucosa in vitro, Respirology. 2005, 10 (Suppl): A126 (#170).

 

Kwok R.P., Leung Y.H., Sun J.Z., Yan C.P.K., Ooi C.G.C., Ho P.L., Tipoe G.L., Lam W.K. and Tsang K.W.T., The effects of gelomyrtol ForteÒ on human ciliary beat frequency in bronchiectasis subjects in vitro, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2006, Abstract Book 086: pp.54.

 

Kwok R.P., Leung Y.H., Sun J.Z., Yan C.P.K., Ooi C.G.C., Ho P.L., Tipoe G.L., Lam W.K. and Tsang K.W.T., The effects of gelomyrtol forteÒ on human ciliary beat frequency in bronchiectasis subjects in vitro, Respirology. 2005, 10 (Suppl): A126 (#169).

 

Kwok R.P., Leung Y.H., Sun J.Z., Yan C.P.K., Ko K.W., Ooi C.G.C., Ho P.L., Tipoe G.L., Lam W.K. and Tsang K.W.T., The effects of myrtol standardized on human ciliary beat frequency in vitro, European Respiratory Medicine. 2005, 26 (Suppl 49): 100S (#714).

 

Kwong Y.L., Lau W.C.S., Ho S.L., Epstein R., Young R.T.T., Chan H.H.L., Tse H.F., Lam L., Chen W.H., Lee K.L.F., Ip M.S.M., Tsang K.W.T., Lam B., Tang S.C.W., Chan R.H.W., Lee S.W.L., Tan K.C.B., Yeung C.K., Chan D.T.M., Wong R.W.S., Choy C.B.Y., Wong B.C.Y., Li F.K., Lo W.K., Lui S.L., Cheung R.T.F., Mak W., Ho J.C.M., Mok T.M.Y., Kung A.W.C., Cheung B.M.Y., Chow W.S., Yuen R.M.F. and Wat N.M.S., In: Lau CP, Kumana CR, Lai CL, Lai KN, Lam KSL, Lam WK, Problem-Based Medical Case Management. Hong Kong, Hong Kong University Press, 2005.

 

Lam W.K. and Tsang K.W.T., Severe acute respiratory syndrome : what lessons have been learnt? - an update, e-Bulletin of the Royal College of Physicians of Edinburgh. 2006.

 

Mak J.C.W., Leung C.M., Ho S.P., Law K.W., Tsang K.W.T., Lam W.K., Ip M.S.M. and Chan M.M.W., Best Poster - Genetic Susceptibility Of Transforming Growth Factor-beta1 Common Polymorphisms To Chinese Patients With Asthma, Hong Kong Allergy Convention 2005 . 2005.

 

Mak J.C.W., Ho S.P., Leung Y.H., Ho P.L., Ooi C.G.C., Tipoe G.L., Yan C.P.K., Ip M.S.M., Lam W.K. and Tsang K.W.T., Elevated levels of transforming growth factor-beta(1) in serum of patients with stable bronchiectasis, Respiratory Medicine. 2005, 99: 1223-1228.

 

Mak J.C.W., Leung C.M., Ho S.P., Law K.W., Tsang K.W.T., Lam W.K., Ip M.S.M. and Chan M.M.W., Genetic susceptibility of transforming growth factor-beta(1) common polymorphisms to Chinese patients with asthma, Hong Kong Allergy Convention, Hong Kong. 2005, Abstract AB25: p.54.

 

Mak J.C.W., Hui W.S., Tipoe G.L., Lam W.K. and Tsang K.W.T., Regulation of cytokine- and phorbol ester-mediated interleukin (IL)-8 expression in the absence of presence of pyocyanin in human bronchial epithelial cell line: roles of protein kinase C and mitogen-activated protein kinases, European Respiratory Journal. 2005, 26 (Suppl 49): 99S (#709).

 

Mak J.C.W., Ho S.P., Wong M.P., Tsang K.W.T., Ip M.S.M., Lam W.K. and Chan M.M.W., Transforming growth factor (TGF)-b[sub]1[/sub] gene common polymorphisms and plasma TGF-b[sub]1[/sub] levels in patients with lung cancer, European Respiratory Journal. 2005, 26 (Suppl 49): 435S (#2797).

 

Ooi C.G.C., Ho J.C.M., Lam B., Lai A.Y.K., Tsang K.W.T. and Lam W.K., Relationship between MR intra-abdominal fat parameters and cardiovascular risk parameters in obstructive sleep apnoea, Respirology. 2005, 10 (Suppl): A176 (#366).

 

Pan N.Y., Hui W.S., Tipoe G.L., Lam W.K., Tsang K.W.T. and Mak J.C.W., Effects of glucocorticosteroids and antimicrobial drugs on inhibition of IL-1-beta and PDBu-induced IL-8 release in the presence of pyocyanin in bronchial epithelial cell line, European Respiratory Journal. 2005, 26(Suppl 49): 99s.

 

SN L.E.E., CY T.A.M. and Tsang K.W.T., Tuberculin skin test, In: Tuberculosis Manual. Edited by CM Tam and CC Leung. Hong Kong, Department of Health, HKSAR, 2006, 92-98.

 

Tsang K.W.T., Chest X-Ray, In: Problem-based Medical Case Management. Edited by CP Lau. Hong Kong, Hong Kong University Press, 2006, 281-297.

 

Tsang K.W.T., Frequent exacerbations of bronchiectasis, at American Thoracic Society International Conference on "Difficult pulmonary infections" in San Diego, USA 19-24 May. 2006.

 

Tsang K.W.T., Eng P., Liam C.K., Shim Y.S. and Lam W.K., H5N1 influenza pandemic: contingency plans, Lancet (London, England : Online). 2005, 366(9485): 533-534.

 

Tsang K.W.T., Non-antibiotic strategy for pulmonary infection, at 'International Symposium' at the 46th Annual Meeting of the Japanese Respiratory Society in Takyo, Japan 1-3 June. 2006.

 

Tsang K.W.T., Novel targeted therapies, Invited Distinguished Speaker at "10th Hong Kong Medical Forum', Hong Kong, 16-17 July. 2005.

 

Tsang K.W.T., Shim Y.S., Wong T.K., Liam C.K., Eng P., Lam W.K. and Seto W.H., Possible case scenarios and logistic issues in H5N1 pandemic, Respirology. 2006, 11: 520-522.

 

Tsang K.W.T., Shortness of breath and COPD, Abstract Book of Hong Kong College of Phycians Annual Scientific Meeting, 5-6 Nov. 2005, 20.

 

Tsang K.W.T., Spring Meeting of Korean Academy of Tuberculosis and Respiratory Disease, Daejeon, Korea. 2006.

 

Tsang K.W.T., Target therapy in non-small lung cancer (NSCLC), Invited Speaker at "10th Hong Kong Medical Forum", Hong Kong 16-17 July, Programme Book. 2005, 22.

 

Wang J., Ho J.C.M., Lam W.K., Ip M.S.M., Chan M.M.W. and Tsang K.W.T., Lymphoepithelioma-like-carcinoma of the lung : experience with 13 cases, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2006, Abstract Book 104: pp. 59.

 

Wong M., Yasufuku K., Nakajima T., Motohashi S., Iyoda A., Suzuki M., Sekine Y., Shibuya K., Iizasa T., Hiroshima K., Tsang K.W.T., Ip M.S.M., Lam W.K. and Fujisawa T., Endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA) in the diagnosis of sarcoidosis, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2006, Abstract Book 092: pp. 57.

 

Wong M., Yasufuku K., Nakajima T., Motohashi S., Iyoda A., Suzuki M., Sekine Y., Shibuya K., Iizasa T., Hiroshima K., Tsang K.W.T., Lam W.K. and Fujisawa T., Endobronchial ultrasound guided transbronchial needle aspiration (EBUS-TBNA) in the diagnosis of sarcoidosis, American Journal of Respiratory and Critical Care Medicine. 2006, 173(3): A610.

 

Yip P.S.F., Lam K.F., Lau E.H.Y., Chau P.H. and Tsang K.W.T., A comparison study of real time fatality rate: SARS in Hong Kong, Singapore, Taiwan, Toronto and Beijing, China, Journal of the Royal Statistical Society . Series A, , Statistics in society. 2005, 168 part I: 233-243.

 

Researcher : Tsang RCW



List of Research Outputs

 

Chan D.T.M., Tsang R.C.W., Zhang Q. and Yung S.S.Y., Mycophenolic Acid Reduces Matrix Synthesis in Human Mesangial Cells Stimulated with Anti-DNA Antibodies, Journal of the American Society of Nephrology. 2005, 16: 420A.

 

Lui S.L., Chan K.W., Tsang R.C.W., Yung S.S.Y., Lai K.N. and Chan D.T.M., Effect of rapamycin on renal ischemia reperfusion injury, Joint symposium on extracorporeal support for multi-organ failure organized by Hong Kong College of Physicians Scientific Symposium and Hong Kong Society of Nephrology Annual Scientific Meeting, 10-11 September 2005, Hong Kong. 2005.

 

Yung S.S.Y., Zhang Q., Tsang R.C.W. and Chan D.T.M., Binding and internalisation of anti-DNA antibodies induce altered cellular functions in human mesangial cells - implications in the pathogenesis of lupus nephritis, 11th Medical Research Conference, 14 January, 2006. 49.

 

Yung S.S.Y., Tsang R.C.W., Sun Y., Leung J.K.H. and Chan D.T.M., Effect of Human Anti-DNA Antibodies on Proximal Renal Tubular Epithelial Cell Cytokine Expression: Implication on Tubulointerstitial Inflammation in Lupus Nephritis, Journal of the American Society of Nephrology. 2005, 16: 3281-3294.

 

Yung S.S.Y., Lee Y.Y.C., Zhang Q., Leung J.K.H., Lau S.K., Tsang R.C.W. and Chan D.T.M., Elevated glucose concentrations induce thrombospondin-1 synthesis in proximal renal tubular epithelial cells thereby stimulating fibronectin synthesis through TGF-b1 dependent and TGF-b1 independent pathways, Nephrology Dialysis Transplantation. 2006, 21: 1504-1513.

 

Yung S.S.Y., Tsang R.C.W., Leung J.K.H. and Chan D.T.M., Increased mesangial cell hyaluronan expression during active lupus nephritis is mediated by anti-DNA antibody-induced IL-1beta, Kidney International. 2006, 69(2): 272-280.

 

Yung S.S.Y., Lee Y.Y.C., Zhang Q., Tsang R.C.W. and Chan D.T.M., Thrombospondin-1 Induced by High Glucose Concentration Mediates Fibronectin Synthesis in Proximal Renal Tubular Epithelial Cells Through Both TGF-beta1 Dependent and TGF-beta1 Independent Pathways, Journal of the American Society of Nephrology. 2005, 16: 662A.

 

Researcher : Tsang VYC



List of Research Outputs

 

Tse H.F., Lam Y.M., Tang M.O., Tsang V.Y.C., Siu C.W.D. and Lau C.P., Avoidance of Left Ventricularof Dyssnchrony Detected by Tissue Doppler Echocardiography by Permanent Right Ventricular Septal Pacing in Patients with High Grade atrioventricular block, JACC. 2006, 47: 23A.

 

Tse H.F., Siu C.W.D., Lee K.L.F., Fan K., Chan H., Tang M.O., Tsang V.Y.C., Lee S.W.L. and Lau C.P., The incremental benefit of rate-adaptive pacing on exercise performance during cardiac resynchronization therapy., J Am Coll Cardiol . 2005, 46(12): 2292-7.

 

Researcher : Tsang WL



List of Research Outputs

 

Guo H., Leung J.C.K., Chan L.Y., Lui S.L., Tsang W.L. and Lai K.N., Modulation of intra-pulmonary TGF-beta expression by mycophenolate mofetil in lupus prone MRL/lpr mice, Lupus. 2005, 14(8): 583-592.

 

Tang S.C.W., Leung J.C.K., Chan L.Y., Tsang W.L. and Lai K.N., Activation of tubular epithelial cells in diabetic nephropathy and the role of the peroxisome proliferator-activated receptor-gamma agonist, Journal of American Society of Nephrology. 2006, 17(6): 1633-1643.

 

Tang S.C.W., Leung J.C.K., Chan L.Y., Tsang W.L. and Lai K.N., Role of PPAR-g agonist in diabetic nephropathy: An in vivo study, Journal of American Society of Nephrology. 2005, 16: 613A.

 

Zhong Q., Leung J.C.K., Chan L.Y., Tsang W.L., Chen X. and Lai K.N., The study of Chinese medicinal herbal formula Shen San Fang in the treatment of experimental IgA nephropathy, the American Journal Of Chinese Medicine. 2005, 33(4): 613-626.

 

Researcher : Tse EWC



Project Title:

The role of LIM-only protein, LM04, in the pathogenesis of sporadic ovarian cancer in Chinese

Investigator(s):

Tse EWC, Kwong YL

Department:

Medicine

Source(s) of Funding:

Small Project Funding

Start Date:

11/2003

 

Abstract:

To assess the level of expression of LMO4 in sporadic ovarian cancer; to determine correlation between LMO4 expression and BRCA1 mutations in sporadic ovarian cancer; to determine correlation between LMO4 expression and clinical behaviour of sporadic ovarian cancer.

 

Project Title:

The study of PIN1 over-expression in multiple myeloma

Investigator(s):

Tse EWC, Kwong YL

Department:

Medicine

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

Completion Date:

10/2006

 

Abstract:

To investigate if PIN1 is over-expressed in myeloma cells; to study the effect of PIN1 down-regulation on the proliferation of myeloma cells.

 

Project Title:

Characterization of the interaction between Pin1 and HBx in human hepatocellular carcinoma

Investigator(s):

Tse EWC

Department:

Medicine

Source(s) of Funding:

Merit Award for RGC CERG Funded Projects

Start Date:

01/2006

 

Abstract:

N/A

 

Project Title:

Characterization of the interaction between Pin1 and HBx in human hepatocellular carcinoma

Investigator(s):

Tse EWC, Wong KB, Kwong YL

Department:

Medicine

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

01/2006

 

Abstract:

To characterize the interaction between Pin1 and HBx; to investigate the role of this interaction in the pathogenesis of HCC; to understand the structural basis of this interaction.

 

List of Research Outputs

 

Cheung W.W., Hwang G.Y.Y., Tse E.W.C. and Kwong Y.L., Alemtuzumab induced complete remission of autoimmune hemolytic anemia refractory to corticosteroids, splenectomy and rituximab, Haematologica. 2006, 91(5suppl): ECR13.

 

Pang R.W.C., Poon R.T.P., Lee K.W., Fan S.T., Kwong Y.L. and Tse E.W.C., PIN1 interacts with a specific serine-proline motif of hepatitis B virus X protein to enhance hepatocarcinogenesis (Abstract), The 97th Annual Meeting of the American Association of Cancer Research, Washington D.C., U.S.A., 1 - 5 April 2006.

 

Tse E.W.C., Best Thesis Award- Gold Award, Hong Kong College of Physicians. 2005.

 

Tse E.W.C., Yip S.F., Ooi C.G.C. and Kwong Y.L., Subarachnoid haemorrhage: more than meets the eye, British Journal of Haematology. 2006, 132(4): 383.

 

Researcher : Tse EYY



List of Research Outputs

 

Lam C.L.K., Tse E.Y.Y., Gandek B. and Fong D.Y.T., The SF-36 Summary Scales is Valid, Reliable, and Equivalent in a Chinese Population, Journal of Clinical Epidemiology. 2005, 58(8): 815-822.

 

Lam T.P., Lam K.F. and Tse E.Y.Y., Why do primary care doctors undertake postgraduate diploma studies in a mixed private/public Asian setting?, Postgraduate Medical Journal. BMJ Publ. Group Ltd & the Fellowship of Postgraduate Med., 2006, 82: 400-403.

 

Researcher : Tse HF



Project Title:

Neovascularization of ischemic myocardium by autologous bone marrow cells transplantation

Investigator(s):

Tse HF, Lau CP, Kwong YL, Nicholls JM

Department:

Medicine

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

09/2002

Completion Date:

08/2005

 

Abstract:

The aim of this study is to compare the effect of bone marrow endothelial progenitor cells versus bone marrow mononuclear cells (MNCs) transplantation on neovascularization, cardiomyocyte apoptosis, collagen deposition and myocardial function in an animal model of chronic myocardial ischemia. The results of this study will provide important information regarding the optimal use and the basic mechanisms of autologous bone marrow transplantation for enhancement of neovascularization and improving heart function in patients with "end-stage" IHD.

 

Project Title:

Comparative evaluation of platelet and coagulation activation between transvenous cryoablation and radiofrequency ablation for pulmonary vien isolation in patients with atrial fibrillation

Investigator(s):

Tse HF, Lau CP, Kwong YL

Department:

Medicine

Source(s) of Funding:

Small Project Funding

Start Date:

11/2003

Completion Date:

10/2005

 

Abstract:

To compare the potential thrombogenic risk of transvenous cryoablation versus conventional radiofrequency energy during pulmonary vein (PV) ablation procedure for treatment of atrial fibrillation (AF).

 

Project Title:

Direct intramyocardial implantation of autologous bone marrow cells for enhancement of neovascularization in patients with "End-Staged" coronary artery disease

Investigator(s):

Tse HF, Lau CP, Kwong YL

Department:

Medicine

Source(s) of Funding:

S.K. Yee Medical Foundation - General Award

Start Date:

01/2004

 

Abstract:

To determine the safety and efficacy of direct intramyocardial delivery of bone marrow cells using electromechanical guided injection; to investigate the angiogenic ability of implanting autologous bone marrow cells in patients with end-stage coronary artery disease.

 

Project Title:

Functional role of pacemaker current, I(f) in sinoatrial node probed by somatic gene transfer of bioengineered HCN channels in swine

Investigator(s):

Tse HF, Lau CP, Li GR, Li R.

Department:

Medicine

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

09/2004

Completion Date:

09/2006

 

Abstract:

To demonstrate the efficacy of gene transfer technique to SA node of pigs in vivo by delivering of adenoviral vectors encoding the green fluorescent protein (GFP); to modulate the pacing activity of native endogenous pacemaker cells (SA nodal cells) via dominant-negative suppression by HCNI-AAA or overexpression of HCN constructs with distinct activation profiles using adenoviral vectors.

 

Project Title:

Relationship between endothelial progenitor cells and markers of thrombogenesis and platelet activation in atrial fibrillation

Investigator(s):

Tse HF, Lip GYH, Lau CP, Kwong YL

Department:

Medicine

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

 

Abstract:

We hypothesise a relationship between the numbers of circulating EPCs and the markers of coagulation, platelet activiation and inflammation in patients with AF; we hypothesis that the numbers of circulating EPCs and vascular endothelial function predicts the outcome of cardioversion for AF.

 

Project Title:

Functional role of pacemaker current, I(f) in sinoatrial node probed by somatic gene transfer of bioengineered HCN channels in swine

Investigator(s):

Tse HF

Department:

Medicine

Source(s) of Funding:

Merit Award for RGC CERG Funded Projects

Start Date:

01/2005

Completion Date:

12/2006

 

Abstract:

N/A

 

Project Title:

Relationship between Endothelial Progenitor Cells and Initiation, Progression and Clinical Manifestation of Atherosclerosis

Investigator(s):

Tse HF, Lau CP, Kwong YL

Department:

Medicine

Source(s) of Funding:

Small Project Funding

Start Date:

01/2006

 

Abstract:

Background: - Cardiovascular risk factors, such as hypertension and smoking, induce endothelial injury and inflammatory response, leading to formation of atherosclerotic lesions. The erosion and rupture of atherosclerotic plaque cause myocardial infarction, sudden cardoiac death and stroke. - Endothelial dysfunction and cell loss are prominent features in atherosclerosis (1). Therefore, maintenance of endothelial integrity is critical for the prevention of athersclerotic diseases. - Endothelial progenitor cells (EPCs) originating from the bone marrow derived cells, which express a variety of endothelial cell markers (2), play a significant role in repair (re-endothelialization) of injured blood vessels (3-5) and neovascularization of ischemic tissues (6-8). - Recent clinical studies demonstrated that cardiovacular risk factors are associated with reduced levels of circulating EPC (9), and the functional integrity of the endothelium correlated with the activities of EPCs (10). - Furthermore, continuous endothelial depletion or exhaustion of a presumed finite supply of EPC in patients with chronic diseases may reduce the number of circulating EPC. Indeed, in patients with chronic diseases, such as heart failure or diabetes, the number of EPC decreased and their function were impaired (9). - Circulating EPC provide an endogenous repair mechanism to counteract ongoing endothelial injury induced by atherosclerotic risk factor and to replace dysfunctional endothelium to prevent the progression of atherosclerosis. - On the other hand, the level of circulating mature endothelial cells may reflect the degree of ongoing endothelium loss from the damage vasculture. - Therefore, detection and quantification of circulating EPCs and mature endothelial cells may provide a novel marker for vascular function in patients with cardiovascular diseases. Whether this novel index of EPCs count reflects the atherosclerotic burden remains not clear. Objective: The aim of this study are - to investigate whether the ratio of the levels of circulating EPCs versus the level of circulating endothlial cells correlate with the amount of atherosclerotic burdens. - to evulate the interaction between atherosclerotic burden and systemic platelet and coagulation activation and inflammation in patients with cardiovascular diseases. References: 1. Drexler H, et al. J Mol Cell Cardiol. 1999;31:51-60. 2. Peichev M, et al. Blood 2000;95:952-8. 3. Kong D, et al. Circulation 2004;110:2039-46. 4. Fuujiyama S, et al. Circ Res. 2003;93:980-9. 5. Werner N, et al. Circ Res. 2003;93:e17-24. 6. Raffi S, et al. Nat Med 2003;9:702-12. 7. Takahashi T, et al. Nat Med. 1999;5:434-8. 8. Dzau VJ, et al. Hypertension 2005/46:7-18. 9. Vasa M, et al. Circ Res 2001;89:e1-7. 10. Hill JM, et al. N Engl J Med 2003;348:593-600.

 

Project Title:

Hypoxia-mediated differentiation of murine and human embryonic stem cells into cardiomyocytes: mechanistic roles of calcium and ion channels

Investigator(s):

Tse HF, Yang HT, Li RA, Fung ML, Wong TM, Lau CP

Department:

Medicine

Source(s) of Funding:

NSFC/RGC Joint Research Scheme

Start Date:

01/2006

 

Abstract:

The main objectives of this project are: 1/ To determine whether hypoxia is a critical physiological stimulus for the differentiation of CMCs 2/ To determine the role of calcium and its key regulatory protein RyR2 in hypoxia-mediated differentiation of ESCs 3/ To investigate the effect of hypoxia on the development changes of ionic channels during cardiac differentiation of ESCs

 

Project Title:

Embryonic stem cell transplantation as a novel therapy for post-infarct left ventricular remodeling

Investigator(s):

Tse HF

Department:

Medicine

Source(s) of Funding:

Merit Award for RGC CERG Funded Projects

Start Date:

01/2006

 

Abstract:

N/A

 

Project Title:

Embryonic stem cell transplantation as a novel therapy for post-infarct left ventricular remodeling

Investigator(s):

Tse HF, Li R, Li GR, Lau CP

Department:

Medicine

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

01/2006

 

Abstract:

To determine whether the differentiation status of embryonic stem cells is important in salvaging heart function in chronic heart failure; to determine whether the timing of embryonic stem cell transplantation is important in salvaging heart function in chronic heart failure.

 

List of Research Outputs

 

Chan Y.H., Lau K.K., Li S.W., Shu X.O., Lau C.P. and Tse H.F., Lower level of phytoestrogen intake correlates with poorer vascular endothelial function in patients with high risk for cardiovascular events, European Heart Journal. 2006, 27: 291.

 

Chen W.H., Kaul U., Leung S.K., Lau Y.K., Tan H.C., Leung A.W., Lee M.K., Li S.K., Ng W., Lee P.Y., Lam K.F., Tse H.F. and Lau C.P., A randomized, double-blind, placebo-controlled trial of abciximab for prevention of in-stent restenosis in diabetic patients after coronary stenting: results of the ASIAD (Abciximab in Stenting Inhibitis restenosis Among Diabetics) Trial, J Invasive Cardiol. 2005, 17(10): 534-8.

 

Cheung B.M.Y., Manil Y.B., Tse H.F., Kumana C.R. and Lau C.P., Advantages of blood pressure optimization, Adv Ther. 2005, 22(4): 285-96.

 

Hu R., Lee P.Y., Lau C.P. and Tse H.F., Impaired Nitrate-Medicated Dilatation Could Reflect Nitrate Tolerance and Predicted Need of Revascularization, JACC. 2006, 1000-159.

 

Hu R., Zhang X.X., Wang W.Q., Lau C.P. and Tse H.F., Smoking, homocysteine and degree of arteriolar retinopathy., Atherosclerosis . 2005, 183(1): 95-100.

 

Kwong Y.L., Lau W.C.S., Ho S.L., Epstein R., Young R.T.T., Chan H.H.L., Tse H.F., Lam L., Chen W.H., Lee K.L.F., Ip M.S.M., Tsang K.W.T., Lam B., Tang S.C.W., Chan R.H.W., Lee S.W.L., Tan K.C.B., Yeung C.K., Chan D.T.M., Wong R.W.S., Choy C.B.Y., Wong B.C.Y., Li F.K., Lo W.K., Lui S.L., Cheung R.T.F., Mak W., Ho J.C.M., Mok T.M.Y., Kung A.W.C., Cheung B.M.Y., Chow W.S., Yuen R.M.F. and Wat N.M.S., In: Lau CP, Kumana CR, Lai CL, Lai KN, Lam KSL, Lam WK, Problem-Based Medical Case Management. Hong Kong, Hong Kong University Press, 2005.

 

Lam J.C.M., Lam B., Lam C.L., Fong D.Y.T., Wang J., Tse H.F., Lam K.S.L. and Ip M.S.M., Obstructive sleep apnoea and the metabolic syndrome in community based Chinese adults in Hong Kong, Respiratory Medicine. 2006, 100: 980-987.

 

Lam J.C.M., Lam B., Lam C.L.K., Fong D.Y.T., Wang J.K.L., Tse H.F., Lam K.S.L. and Ip M.S.M., Obstructive sleep apnoea and the metabolic syndrome in community-based, Chinese Adults in Hong Kong Resp Med . 2006, 100: 980-987.

 

Lau C.P., Lee K.L.F., Tse H.F., Echt D., Heaven D., Smith W. and Hood A., First Acute demonstration leadless pacing in patients using acoustic energy, Heart Rhythm. 2006, 3: S102.

 

Lau C.P., Lee K.L.F., Tse H.F., Echt D., Heaven D., Smith W. and Hood M., First acute demonstration of leadless pacing in patients using acoustic energy, Europace. 2006, 3/5.

 

Lau E.O.Y., Tse H.F., Chan R.H.W., Chen W.H., Lee P.Y., Lee S.W.L., Chwang A.T.Y. and Lau C.P., Prediction of aortic augmentation index using radial pulse transmission-wave analysis, Journal of Hypertension. Lippincott Williams & Wilkins, 2006, 24(4): 723-730.

 

Lee K.L.F., Tse H.F., Mullen T.J., Burnes J.E. and Lau C.P., LV pacing before intrinsic RV conduction results in improved RV hemodynamics, Europace. 2006, 18P/21.

 

Lee M.Y.K., Tse H.F., Man R.Y.K. and Vanhoutte P.M.G.R., Genomic changes in cultured porcine regenerated coronary endothelial cells, 11th International Vascular Neuroeffector Mechanisms and Cardiovascular Pharmacology and Medicine Symposia, Shanghai-Suzhou 2006, 26-29 June 2006. 21.

 

Lee P.Y., Chen W.H., Ng W., Cheng X., Tse H.F., Lau C.P. and Kwong J.Y., Low-dose aspirin increase aspirin resistance in patients wtih coronary artery disease, Am J Med 2005. 2005, 118: 723-7.

 

Lee Y.K.M., Tse H.F., Man R.Y.K. and Vanhoutte P.M.G.R., Genomic changes in culltured porcine regenrated coronary endothelial cells, International Symposium on Healthy Aging: A Global Challenge for the 21st Century, Hong Kong March 4-5, 2006. 53, OP15.

 

Li G.R., Deng X., Sun H., Chung S.S.M., Tse H.F. and Lau C.P., Ion channels in mesenchymal stem cells from rat bone marrow. , Stem Cells. 2006, 24: 1519-1528.

 

Liu B., Wang J., Chan K.M.J., Tjia W.M., Deng W., Guan X.Y., Huang J., Li S.K.M., Chau P.Y.P., Chen D., Pei D., Pendas A., Cadiñanos J., López-Otín C., Tse H.F., Hutchison C., Chen J., Cao Y., Cheah K.S.E., Tryggvason K. and Zhou Z., Genomic Instability In Laminopathy-based Premature Aging, Nature Medicine. 2005, 11 (7): 780-785.

 

Ng W., Wong R.W.M., Chen W.H., Tse H.F., Lee P.Y., Lai K.C., Li L.S.W., Ng M.M.T., Lam K.F., Cheng X. and Lau C.P., Incidence and predictors of upper gastrointestinal bleeding in patients receiving low-dose aspirin for secondary prevention of cardiovascular events in patients with coronary artery disease, World Journal of Gastroenterology. Beijing, China, The WJG Press, 2006, 12(18): 2923-2927.

 

Ripley K.L., Tse H.F., Vleet J.F.V.A.N. and Pelkey W.L., Cryoablation of skeletal muscle: the effect of contact force and application duration on lesion size, European Heart Journal. 2006, 27:291: P2084.

 

Ripley K.L., Tse H.F., Vleet J.V. and Pelkey W.L., Effect of contact and duration on cryoablation lesion size, Europace . 2006, 8 Supplement 1: 229/2.

 

Ripley K.L., Tse H.F., Vleet J.F.V.A.N., Gage A.A. and Pelkey W.L., The effects of docetaxil and sirolimus on cryoablation lesions in normal skeletal muscle, European Heart Journal . 2006, 27: 291.

 

Ripley L., Tse H.F., Vleet J.F., Gage A.A. and Pelkey W.L., Role of pharmacologic agents in cryoablation of skeletal muscle, Europace. 2006, 8 Supplement 1: 229/3.

 

Siu C.W.D., Jim M.H., Tse H.F., Fan K., Chau M.C. and Chow W.H., Comparison of the efficacy and safety profiles fo intravenuous vitamin K and fresh frozen plasma as treatment of warfarin-related over-anticoagulation in patients with mechanical heart valves, Am J Cardiol. 2006, 97(3): 409-11.

 

Siu C.W.D., Jim M.H., Kung A.W.C., Lau C.P. and Tse H.F., The Outcomes of Thyrotoxicosis Related New-Onset Atrial Fibrillation, JACC. 2006, 47: 10A.

 

Siu D.C.H., Yeung C.Y., Kung A.W.C., Lau C.P. and Tse H.F., Prevalence, clinical characteristics and outcomes of thyrotoxic dilated cardiomyopathy as the initial presentation in patients with thyrotoxicosis, American Heart Association Annual Scientific Meeting, 13-16 November 2005, Dallas, USA. 2005.

 

Tse H.F., ATV 時事追擊 “Stem Cell”, 2006.

 

Tse H.F., Advising Patients on Risk Factors Management of CV Diseases- AstraZeneca Hong Kong Limited, 2005.

 

Tse H.F., Lee K.L.F., Wan S.H., Yu Y., Walter H., Pastore J., Zhu Q., Kenknight B., Spinelli J. and Lau C.P., Area of left ventricular regional conduction delay and preserved myocardium predict response to cardiac resynchronization therapy., J Cardiovasc Electrophysiol. 2005, 16: 690-5.

 

Tse H.F., Atrial Fibrillation: from pathophysiology to catheter ablation, Heart Rhythm. 2006, 3: 896-7.

 

Tse H.F., Lam Y.M., Tang M.O., Tsang V.Y.C., Siu C.W.D. and Lau C.P., Avoidance of Left Ventricularof Dyssnchrony Detected by Tissue Doppler Echocardiography by Permanent Right Ventricular Septal Pacing in Patients with High Grade atrioventricular block, JACC. 2006, 47: 23A.

 

Tse H.F., Xue T., Lau C.P., Siu C.W.D., Wang K., Zhang Q.Y., Tomaselli G.F., Akar F.G. and Li R.A., Bioartifical sinus node constructed via in vivo gene transfer of an engineered pacemaker HCN channel reduces the dependence on electronic pacemaker in a sick sinus syndrome model, Circulation. 2006, 114: 1000-1011.

 

Tse H.F. and Lau C.P., Catheter ablation for persistent atrial firillation: are we ready for "prime time"?, J Cardiovasc electrophysiol. 2005, 16(11): 1148-9.

 

Tse H.F., Chairman, Organizing Committee, International Symposium on Healthy Aging: A Global challenge for the 21st century Mar4-5, 2006. 2006.

 

Tse H.F., Co-Chairmen of Local Organizing Commmittee, The Institute of Cardiovascular Science & Medicine , 9th Scientific Meeting. 2005.

 

Tse H.F., Expert Panelist "Therapeutic Role of Endothelial Progenitor Cells in Cardiovascular Diseases", 14th Annual Scientific Congress Hong Kong College of Cardiolgoy. 2006.

 

Tse H.F., Hypertension in Patients with Concomitant Cardiac Disorders: Heart Failure, Atrial Fibrillation and Coronary Heart Disease., In: Lip GYH, Hall JE(eds)., In: Comprehensive Hypertension. New York, NY. New York, NY, Elsevier, Inc, 2006.

 

Tse H.F., Hettrick D.A., Mehra R. and Lau C.P., Improved atrial mechanical efficiency during alternate-and multiple site atrial pacing compared with conventional right atrial appendage pacing: implications for selective site pacing to prevent atrial fibrillation, J Am Coll Cardiol . 2006, 47(1): 209-12.

 

Tse H.F., International Press Releases: - ACC 06, USA Affiliation: Research Centre of Heart, Brain, Hormone and Healthy Aging, University of Hong Kong "Prospective Randomized Trial of Direct Endomyocardial Implantation of Bone Marrow Cells for Therapeutic Angiogenesis in Coronary Artery Diseases (PROTECT-CAD) , 2006.

 

Tse H.F., Invited Speaker " ECG Interpretation", Hong Kong Doctors Union. 2006.

 

Tse H.F., Invited Speaker " How to mend a broken heart?", The 8th South China International Congress of Cardiology, Guangzhou, 30 Mar - 2 Apr, 2006. 2006.

 

Tse H.F., Invited Speaker " Stem Cells - From Bench to Bedside, The Federation's Annual Scientific Meeting . 2006.

 

Tse H.F., Invited Speaker "Site Selection for Atrial Pacing in Patients with Atrial Fibrillation , 15th World Congress in Cardiac Electrophysiology and cardiac Techniques, Nice, France. 2006.

 

Tse H.F., Invited Speaker : Overview of Cardiac Resynchronization Therapy" "Ventricular Dyssnchrony: Tips and Tricks for Patient Identification, Implant and Follow-up, Medtronic Ltd. 2006.

 

Tse H.F., Invited Speaker,"Ablation for Atrial Fibrillation", XiZi Forum of New Cardiovascular International Therapeutics (CIT-XIZI) May 11-14, 06, Hangzhou, China. 2006.

 

Tse H.F., Local Faculty, 5th Echo Hong Kong Nov 24-27, 05. 2005.

 

Tse H.F., Mass Media " ATV World Inside Story" Interview " (Stem Cells), ATV World. 2006.

 

Tse H.F., Member of the Editorial Board, Journal of Cardiovascular Pharmacology and Therapeutics, 2006.

 

Tse H.F., Member of the Editorial Board, Pacing and Clinical Electrophysiology, 2006.

 

Tse H.F., Member, Editorial Advisory Board of Recent Patents on Engineering, 2006.

 

Tse H.F., Members, International Symposium on Healthy Aging : A global challenge for the 21st century. 2006.

 

Tse H.F., Garg A., Bohn D., Lee Y.L. and Lau C.P., Muscle noise effects on atrial evoked response sensing: implication on atrial auto threshold, Europace. 2006, 8 Supplement 1: 43/5.

 

Tse H.F., Prospective Randomized Trial of direct Endomyocardial Implantation of Bone Marrow Cells for Therapeutic Angiogenesis in Coronary Artery Disease (PROTECT-CAD), USA, American College of Cardiology Foundation-55th Annual Scientific Session, 11-14 March 2006, Georgia World Congress Atlanta. Georgia, USA, 2006.

 

Tse H.F. and Lau C.P., Selection of permanent ventricular pacing site: how far should we go?, J Am Coll Cardiol 2006. 2006, 48: 1649-1651.

 

Tse H.F., Seminar, Guiyang Medical College, Guizhou, China, 31st Mar -1st Apr, 2006. 2006.

 

Tse H.F., 冠心病, 心臟衰竭,心瓣問題, 突發性心臟病, 心房纖維性顫動,高血壓,心律不整, TV Programme : TVB Health Channel. 2005.

 

Tse H.F., Siu C.W.D., Lee K.L.F., Fan K., Chan H., Tang M.O., Tsang V.Y.C., Lee S.W.L. and Lau C.P., The incremental benefit of rate-adaptive pacing on exercise performance during cardiac resynchronization therapy., J Am Coll Cardiol . 2005, 46(12): 2292-7.

 

Tse H.F., Lau C.P., Bloomfield D.M., Park E., Bornzin G.A., Benser M.E., Padeletti L. and Yu C., Transient overdrive pacing prevents orthostatic hypotension in elderly pacemaker patients with chronotropic incompetence, Heart Rhythm. 2006, 3: S246.

 

Wang K., Xue T., Tsang S.Y., Huizen R.V., Wong C.W., Lai K.W.H., Ye Z., Cheng L., Zhang J.C.L., Li G.R., Lau C.P., Tse H.F. and Li R.A., Electrophysiological Properties of Pluripotent Human and Mouse Embryonic Stem Cells, Stem Cells. 2005, 23: 1526-1534.

 

Yiu K.H., Siu C.W.D., Lee K.L.F., Lam L., Chan R.H.W., Lee S.W.L., Lau C.P. and Tse H.F., Adverse Clinical Outcomes in Left-sided Infective Endocarditis Complicated Intravenous drug addict, JACC . 2006, 47: 281A.

 

Yiu K.H., Lau C.P., Lee K.L.F. and Tse H.F., Emerging energy sources for catheter ablation of atrial fibrillation, J Cardiovasc Electrophysiol. 2006, 17: S56-61.

 

Yiu K.H., Miu R., Lee K.L.F., Yung L.Y., Siu C.W.D., Tse H.F., Lam B., Lam J., Ip M.S.M. and Lau C.P., Improvement of sleep Apnea in heart failure patients after cardiac resynchronization therapy is associated with a significant dop in pulmonary arterial pressure, Heart Rhythm. 2006, 3, No. 5: S87.

 

Yiu K.H., Lee K.L.F., Tse H.F., Siu C.W.D., Lam B., Ip M.S.M. and Lau C.P., Improvement of sleep apnea in heart failure patients after cardiac resynchronization therapy is caused by relief of pulmonary congestion as reflected by a drop of pulmonary arterial pressure, Europace. 2006, 10/6.

 

Yiu K.H., Miu K.M., Lee K.L.F., Tse H.F., Siu C.W.D., Lam K., Lam B., Ip M.S.M. and Lau C.P., Improvement of sleep apnea in heart failure patients after cardiac resynchronization therapy is caused by relief of pulmonary congestion sa reflected by a drop of pulmonary congestion as reflected by a drop of pulmonary arterial pressure, Europace . 2006, 8 Supplement 1: 10/6.

 

Yiu K.H., Siu C.W.D., Lee K.L.F., Lam L., Chan R.H.W., Lee S.W.L., Lau C.P. and Tse H.F., Temporal Trend of Infective Endocarditis in Chinese: A Population Based Study Over 10 Years Period, JACC. 2006, 984-24.

 

Zhan H., Tse H.F., Cao J.M. and Lau C.P., Comparative study on characteristics of congestive heart failure patietns with preserved versus abnormal left ventricular systolic function and evaluation effects of therapy, Zhongguo Wei Zhong Bing Ji Jiu Yi Xue. . 2006, 18(4): 210-5.

 

Zhang Q.Y., Wei M., Ge J.B., Qian J.Y. and., Lau C.P., Tse H.F., Increased mast cell accumulation and activity contribute to angiogenesis and preserve microvascular function after coronary microembilization, European Heart Journal. 2006, 27:291: 926.

 

Zhang Q.Y., Ge J.B., Chen J.Z., Zhu J.H., Zhang L.H., Lau C.P. and Tse H.F., Mast Cell Contributes to Cardiomyocyte Apoptosis after Coronary microembolization, J Histochem Cyochem. 2005, 54(5): 515-23.

 

Researcher : Tsoi TH



List of Research Outputs

 

Cheung R.T.F., Chan H.M., Tsoi T.H., Ng P.W., Ng K.K. and Yeung H.M., 腦有所醫:二十二個為「腦」力而加油的感人故事, 2006, 1-216.

 

Fong C.Y.G., Cheng T.S., Lam K., Cheng W.K., Mok B.K.Y., Cheung C.M., Chim J.C.S., Mak W., Chan K.H., Tsang K.L., Kwan M.C., Tsoi T.H., Cheung R.T.F. and Ho S.L., An epidemiological study of motor neuron disease in Hong Kong, Amyotrophic Lateral Sclerosis and Other Motor Neuron Disorders. 168, 2005, 6: 164.

 

Researcher : Tu S



List of Research Outputs

 

Zou B., Lin M.C., Lam S.K., Tu S., Zeng H., Yang Y., Wang J., He H., Jiang S.H., Kung H. and Wong B.C.Y., Distinguished Poster Award, "Hypermethylation status around exon 1 of XIAP-Associated Factor 1(XAF1) in human gastric and colon cancer cell line.", Asian Pacific Digestive Week, Sept. 25-28, Seoul, Korea.. 2005.

 

Zou B., Lin M.C., Lam S.K., Tu S., Zeng H., Yang Y., Wang J., He H., Jiang S.H., Kung H. and Wong B.C.Y., Hypermethylation status around exon 1 of XIAP-Associated Factor 1(XAF1) in human gastric and colon cancer cell line. Asian Pacific Digestive Week, Sept. 25-28, 2005, Seoul, Korea. , Journal of Gastroenterology and Hepatology. 2005, 20: Supp A370.

 

Researcher : Wang AYM



List of Research Outputs

 

Wang A.Y.M. and Lai K.N., The importance of residual renal function in dialysis patients, Kidney International. 2006, 69(10): 1726-1732.

 

Researcher : Wang J



List of Research Outputs

 

Gu Q., Xia H.H.X., Wang J., Wong R.W.M., Chan O.O., Lai K.C., Chan C.K., Yuen R.M.F., Fung F.M.Y., Wong K.W., Lam S.K. and Wong B.C.Y., Update on clarithromycin resistance in Helicobacter pylori in Hong Kong and its effect on clarithromycin-based triple therapy., Digestion. 2006, 72(2-3): 101-106.

 

Gu Q., Xia H.H.X., Wang J., Chan O.O., Lai K.C., Fung F.M.Y., Wong K.W., Cheung K.L., Kung H. and Wong B.C.Y., Update on clarithromycin resistance in Helicobacter pylori in Hong Kong and its effect on clarithromycin-based triple therapy., In: Gu Q, Xia HHX, Wang JD, Chan AOO, Lai KC, Chan CK, Yuen MF, Fung FMY, Wong KW, Cheung HKL, H.F. Kung HF, B.C.Y. Wong BCY.. , J Gastroenterol Hepatol . 2005, 20 (Suppl.): A160.

 

He H., Xia H.H.X., Wang J., Gu Q., Lin M.C., Zou B., Lam S.K., Chan O.O., Yuen R.M.F., Kung H.F. and Wong B.C.Y., Inhibition of human telomerase reverse transcriptase by nonsteroidal antiinflammatory drugs in colon carcinoma, Cancer. 2006, 106(6): 1243-9.

 

Li G., Xia H.H.X., Chen M., Gu Q., Wang J., Peng J., Chan O.O., Cho C.H., So H.L., Lam S.K., Hu P.J., Liang Y.J., Lin H., Berg D.E., Feng Z.H., Langenback R. and Wong B.C.Y., Effects of Cyclooxygenase-1 and -2 Gene Disruption on Helicobacter pylori-Induced Inflammation, Journal of Infectious Diseases. 2006, 193(7): 1037-1046.

 

Li M., Ng S.M., Wang J., Lai L., Leung S.Y., Franco M., Peng Y., He M.L., Kung H.F. and Lin M.C., EFA6A Enhances Glioma Cell Invasion through ADP Ribosylation Factor 6/Extracellular Signal-Regulated Kinase Signaling (Li M. and Ng S.M. are equal first authors)., Cancer Research. 2006, 66(3): 1583-1590.

 

Sun Y., Wang J., Xia H.H.X., Zou B., Lin M.C., Kung H. and Wong B.C.Y., Interferon-β-induced expression of XAF1 requires phosphorylation of STAT1 and a sequential activation of protein kinase C and JNK in colon cancer. Digestive Disease Week 2006, 20-25 May, Los Angeles, USA , Gastroenterology. 2006, 4 Suppl 2: A671.

 

Wang J., Peng Y., Sun Y., He H., Zhu S., An X.M., Li M., Lin M.C., Zou B., Xia H.H.X., Jiang B., Chan O.O., Yuen R.M.F., Kung H.F. and Wong B.C.Y., All-Trans Retinoic Acid Induces XAF1 Expression Through an Interferon Regulatory Factor-1 Element in Colon Cancer, Gastroenterology. 2006, 130(3): 747-758.

 

Wang J., He H., Yu L., Xia H.H.X., Lin M.C., Gu Q., Li M., Zou B., An X.M., Jiang B., Kung H.F. and Wong B.C.Y., HSF1 down-regulates XAF1 through transcriptional regulation, Journal of Biological Chemistry. 2006, 281(5): 2451-2459.

 

Xia H.H.X., He H., Wang J., Gu Q., Lin M.C., Zou B., Yu L., Sun Y., Chan O.O., Kung H.F. and Wong B.C.Y., Induction of apoptosis and cell cycle arrest by a specific c-Jun NH(2)-terminal kinase (JNK) inhibitor, SP-600125, in gastrointestinal cancers., Cancer Letters. 2005, 241(2): 268-74.

 

Yu L., Wang J., Zou B., Lin M.C., Wu Y.L. and Wong B.C.Y., Sulindac Metabolites Induces XAF1 Expression by Inhibition of Extracellular Signal-regulated Kinase 1/2 Phosphorylation in Human Gastric Cancer Cells. Oral presentation, Asian Pacific Digestive Week 2005, Sept. 25-28, 2005, Seoul, Korea , Journal of Gastroenterology and Hepatology. 2005, 20: Supp A299.

 

Yu L., Wang J., Zou B., Wu Y.L. and Wong B.C.Y., XAF1 mediates inhibition of extracellular signal-regulated kinase 1/2 induced apoptosis in human colon cancer cells. Digestive Disease Week 2006, 20-25 May, Los Angeles, USA , Gastroenterology. 2006, 4 Suppl 2: A531.

 

Zou B., Lin M.C., Lam S.K., Tu S., Zeng H., Yang Y., Wang J., He H., Jiang S.H., Kung H. and Wong B.C.Y., Distinguished Poster Award, "Hypermethylation status around exon 1 of XIAP-Associated Factor 1(XAF1) in human gastric and colon cancer cell line.", Asian Pacific Digestive Week, Sept. 25-28, Seoul, Korea.. 2005.

 

Zou B., Lin M.C., Lam S.K., Tu S., Zeng H., Yang Y., Wang J., He H., Jiang S.H., Kung H. and Wong B.C.Y., Hypermethylation status around exon 1 of XIAP-Associated Factor 1(XAF1) in human gastric and colon cancer cell line. Asian Pacific Digestive Week, Sept. 25-28, 2005, Seoul, Korea. , Journal of Gastroenterology and Hepatology. 2005, 20: Supp A370.

 

Researcher : Wang K



List of Research Outputs

 

Tse H.F., Xue T., Lau C.P., Siu C.W.D., Wang K., Zhang Q.Y., Tomaselli G.F., Akar F.G. and Li R.A., Bioartifical sinus node constructed via in vivo gene transfer of an engineered pacemaker HCN channel reduces the dependence on electronic pacemaker in a sick sinus syndrome model, Circulation. 2006, 114: 1000-1011.

 

Wang K., Xue T., Tsang S.Y., Huizen R.V., Wong C.W., Lai K.W.H., Ye Z., Cheng L., Zhang J.C.L., Li G.R., Lau C.P., Tse H.F. and Li R.A., Electrophysiological Properties of Pluripotent Human and Mouse Embryonic Stem Cells, Stem Cells. 2005, 23: 1526-1534.

 

Researcher : Wang K



List of Research Outputs

 

Tse H.F., Xue T., Lau C.P., Siu C.W.D., Wang K., Zhang Q.Y., Tomaselli G.F., Akar F.G. and Li R.A., Bioartifical sinus node constructed via in vivo gene transfer of an engineered pacemaker HCN channel reduces the dependence on electronic pacemaker in a sick sinus syndrome model, Circulation. 2006, 114: 1000-1011.

 

Wang K., Xue T., Tsang S.Y., Huizen R.V., Wong C.W., Lai K.W.H., Ye Z., Cheng L., Zhang J.C.L., Li G.R., Lau C.P., Tse H.F. and Li R.A., Electrophysiological Properties of Pluripotent Human and Mouse Embryonic Stem Cells, Stem Cells. 2005, 23: 1526-1534.

 

Researcher : Wang W



List of Research Outputs

 

Wang W., Huang J., Zheng G., Xia H.H.X., Wong R.W.M., Lam S.K. and Wong B.C.Y., Head-to-Head Comparison of H2-Receptor Antagonists and Proton Pump Inhibitors in the Treatment of Erosive Esophagitis: A Meta-Analysis, World Journal of Gastroenterology. 2005, 11(26): 4067-4077.

 

Researcher : Wat NMS



List of Research Outputs

 

Kwong Y.L., Lau W.C.S., Ho S.L., Epstein R., Young R.T.T., Chan H.H.L., Tse H.F., Lam L., Chen W.H., Lee K.L.F., Ip M.S.M., Tsang K.W.T., Lam B., Tang S.C.W., Chan R.H.W., Lee S.W.L., Tan K.C.B., Yeung C.K., Chan D.T.M., Wong R.W.S., Choy C.B.Y., Wong B.C.Y., Li F.K., Lo W.K., Lui S.L., Cheung R.T.F., Mak W., Ho J.C.M., Mok T.M.Y., Kung A.W.C., Cheung B.M.Y., Chow W.S., Yuen R.M.F. and Wat N.M.S., In: Lau CP, Kumana CR, Lai CL, Lai KN, Lam KSL, Lam WK, Problem-Based Medical Case Management. Hong Kong, Hong Kong University Press, 2005.

 

Thomas G.N., Schooling C.M., McGhee S.M., Ho D.S.Y., Cheung B.M.Y., Wat N.M.S., Janus E.D., Lam K.S.L. and Lam T.H., Smoking effect modification on all-cause and vascular mortality associated with the metabolic syndrome: The Hong Kong cardiovascular risk factor study (abstract), 4th Annual Conference of the International Society for the Prevention of Tobacco Induced Disease, 30 September - 2 October 2005, Athens, Greece. Athens, Greece, Int'l Society for the Prevention of Tobacco Induced Disease, 2005.

 

Tso A.W.K., Wat N.M.S., Xu A., Tam S., Fong H.Y., Janus E.D., Tan K.C.B. and Lam K.S.L., Adiponectin/C-reactive protein ratio is an independent surrogate marker predictive of the development of metabolic risks and the metabolic syndrome over 5 years in Chinese, The 6th International Diabetes Federation Western Pacific Region Congress, Bangkok, Oct 2005.

 

Xu A., Wang Y., Xu J., Stejskal D., Tam S., Zhang J., Wat N.M.S., Wong W.K. and Lam K.S.L., Adipocyte fatty acid-binding protein is a plasma biomarker closely associated with obesity and metabolic syndrome, Clinical Chemistry. 2006, 52: 405-413.

 

Researcher : Wong ASP



List of Research Outputs

 

Chim J.C.S., Wong A.S.P., Pang A.W.K., Chu P., Lau J.S., Wong K.F. and Kwong Y.L., Aberrant promoter methylation of the retinoic acid receptor alpha gene in acute promyelocytic leukemia, Leukemia. 2005, 19(22): 2241-6.

 

Researcher : Wong ASY



List of Research Outputs

 

Chim J.C.S., Wong A.S.Y. and Kwong Y.L., Epigenetic inactivation of the CIP/KIP cell-cycle control pathway in acute leukemias, American Journal of Hematology. 2005, 80(4): 282-7.

 

Leung A.Y.H., Wong A.S.Y., Chan G.C.F., Yuen K.Y. and Kwong Y.L., Urinary reactivation of polyoma BK virus but not adenovirus in paediatric and adolescent patients after haematopoietic stem cell transplantation, Bone Marrow Transplantation. 2006, 37(6): 621-3.

 

Researcher : Wong BCY



Project Title:

Effect of XAF1 gene on tumor growth in gastric and colon cancer

Investigator(s):

Wong BCY, Tu S

Department:

Medicine

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

01/2003

 

Abstract:

To study the effect of XAF1 on tumor growth.

 

Project Title:

Regulation of hTERT in relation to non-steroidal anti-inflammatory drugs in gastronintestinal carcinogenesis

Investigator(s):

Wong BCY, Lin MC

Department:

Medicine

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

10/2003

Completion Date:

09/2006

 

Abstract:

Identify the cis-element responsible for NSAIDs-mediated inhibition of hTERT transcription; charaterize the transcription factor(s) and binding sites that is responsible for NSAIDs-mediated inhibition of hTERT transcription.

 

Project Title:

Regulation of hTERT in relation to non-steroidal anti-inflammatory drugs in gastronintestinal carcinogenesis

Investigator(s):

Wong BCY, Lin MC

Department:

Medicine

Source(s) of Funding:

Merit Award for RGC CERG Funded Projects

Start Date:

10/2003

Completion Date:

09/2006

 

Abstract:

N/A

 

Project Title:

Role of Bcl-2 family proteins in non-steroidal anti-inflammatory drug-induced apoptosis of gastric cancer

Investigator(s):

Wong BCY, Xia HHX

Department:

Medicine

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

02/2004

 

Abstract:

To clarify the role of Bcl-2 family proteins in NSAID-induced apoptosis in vitro in this proposal using gastric cancer cell lines.

 

Project Title:

Helicobacter pylori infection and CpG island methylation in gastric carcinogenesis

Investigator(s):

Wong BCY, Epstein R, Chan AOO, Issa J.P., Rashid A.

Department:

Medicine

Source(s) of Funding:

Michael Kadoorie Cancer Genetics Research Fund

Start Date:

10/2004

 

Abstract:

To investigate if CpG island methylation at E-cadherin, as well as other tumor suppressor genes, in normal human gastric mucosa can be reversed by eradicating H. pylori; to establish an animal model to study the regulatory mechnaism of CpG island methylation at E-cadherin in gastirc cancer cell lines by Helicobacter pylori and interleukin 1.

 

Project Title:

Role of cyclooxygenase in helicobacter pylori-induced gastric carcinogenesis

Investigator(s):

Wong BCY

Department:

Medicine

Source(s) of Funding:

Merit Award for RGC CERG Funded Projects

Start Date:

01/2005

 

Abstract:

N/A

 

Project Title:

Role of cyclooxygenase in helicobacter pylori-induced gastric carcinogenesis

Investigator(s):

Wong BCY, Feng Z.H.

Department:

Medicine

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

01/2005

 

Abstract:

To determine the differences in gastric epithelial proliferation and apoptosis as well as in the incidence of gastric precancerous and cancerous lesions between COX deficient mice and wild-type mice after long-term infection with H. pylori; to determine the effects of NSAIDs and specific COX2 inhibitors on gastric proliferation and apoptosis, and their potential role in the prevention of gastric precancerous and cancerous lesions in H. pylori infected Mongolian gerbils.

 

List of Research Outputs

 

Chan O.O. and Wong B.C.Y., Chemoprevention of colorectal cancer, Proceedings, 5th Shanghai International Conference of Gastroenterology, 7-9 July 2006, Shanghai, PR China. 2005, 126.

 

Chan O.O., Hui W.M., Chan C.K., Lai K.C., Hu H.C., Yuen R.M.F., Wong R.W.M., Lau G., Hui C.K., Lam S.K. and Wong B.C.Y., Colonoscopy Demand and Practice in a Regional Hospital over 9 Years in Hong Kong: Resource Implication for Cancer Screening, Gastroenterology. 2006, 130 (4 Suppl 2): A-618.

 

Chan O.O., Hui W.M., Chan C.K., Lai K.C., Hu H.C., Yuen R.M.F., Wong R.W.M., Lau G., Hui C.K., Lam S.K. and Wong B.C.Y., Colonoscopy demand and practice in a regional hospital over 9 years in Hong Kong: Resource implication for cancer screening, Digestion. 2006, 73(2-3): 84-88.

 

Chan O.O., Cheng C., Hui W.M., Hu H.C., Wong Y.H., Lam K.F., Wong R.W.M., Lai K.C., Lam S.K. and Wong B.C.Y., Differing coping mechanisms, stress level and anorectal physiology in patients with functional constipation, World Journal of Gastroenterology. The WJG Press and Elsevier Inc., 2005, 11(34): 5362-5366.

 

Chan O.O., Chu K.M., Lam S.K., Cheung K.L., Law S.Y.K., Kwok K.F., Wong R.W.M., Yuen R.M.F. and Wong B.C.Y., Early prediction of tumor recurrence after curative resection of gastric carcinoma by measuring soluble E-cadherin, Cancer. 2005, 104(4): 740-6.

 

Chan O.O., Peng J., Lam S.K., Lai K.C., Yuen R.M.F., Cheung K.L., Kwong Y.L., Rashid A., Chan C.K. and Wong B.C.Y., Eradication of Helicobacter pylori Infection Reverses E-cadherin Promoter Hypermethylation, Gut. 2006, 55: 463-468.

 

Chan O.O., Hui W.M., Hu H.C., Leung G., Chan C.K., Yuen R.M.F., Lam S.K. and Wong B.C.Y., Familial Aggregation in Constipated Subjects in a Tertiary Referral Center, Gastroenterology. 2006, 130 (4 Suppl 2): A-159.

 

Chan O.O. and Wong B.C.Y., General Mechanisms of Cancer. Edited by: Cho CH and Purohit V , In: Alcohol, Tobacco and Cancer. . Basel, Switzerland, Karger, 2006, 1-12.

 

Chan O.O., Chu K.M., Leung S.Y., Huang C., Sun Y.W., Ko S., Yuen R.M.F., Xia H.H.X., Cho C.H., Hui W.M., Lam S.K., Rashid A. and Wong B.C.Y., Helicobacter pylori infection, interleukin 1 beta polymorphism and predisposition to gastric cancer through the CpG island methylation pathway, Presented at 11th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong, 14 January 2006.

 

Chan O.O., Jim M.H., Lam K.F., Siu D.C.W., Tong S.M., Ng F.H., Hui W.M., Chan C.K., Lai K.C., Hu H.C., Yuen R.M.F., Lau Y.K., Lee S.W.L., Lam S.K. and Wong B.C.Y., Patients with Coronary Artery Disease are at High Risk for Developing Colorectal Cancer and Adenoma: An Interim Analysis of a Prospective Study, Gastroenterology. 2006, 130 (4 Supp 2): A-36.

 

Chan O.O., Hui W.M., Lam K.F., Leung G., Hu H.C., Chan C.K., Yuen R.M.F., Lam S.K. and Wong B.C.Y., The Clinical Characteristics of Patients with Idiopathic Constipation with a Positive Family History, Gastroenterology. 2006, 130 (4 Suppl 2): A-158.

 

Chan O.O., Chu K.M., Sun Y.W., Cheung H.K.L., Lam S.K., Yuen R.M.F., Hui W.M. and Wong B.C.Y., The association between interleukin 1 beta polymorphism and hypermethylation at tumor suppressor genes in gastric cancer. , Gastroenterology. 2005, 128 (Suppl 2): 1399-400.

 

Chan O.O., Lam K.F., Hui W.M., Hu W.H., Li J., Lai K.C., Chan C.K., Yuen R.M.F., Lam S.K. and Wong B.C.Y., Validated questionnaire on diagnosis and symptom severity for functional constipation in the Chinese population, Alimentary Pharmacology and Therapeutics. Blackwell Publishing Ltd, 2005, 22: 483-488.

 

Chan O.O., Chu K.M., Leung S.Y., Huang C., Sun Y., Ko S., Yuen R.M.F., Xia H.H.X., Cho C.H., Hui W.M., Lam S.K., Rashid A. and Wong B.C.Y., Helicobacter pylori Infection, Interleukin 1 Beta Polymorphism and Predisposition to Gastric Cancer Through the Cpg Island Methylation, Gastroenterology. 2006, 130 (4 Suppl 2): A-717.

 

Fan X.M., Jiang X., Gu Q., Ching Y.P., He H., Xia H.H.X., Lin M.C., Chan O.O., Yuen R.M.F., Kung H.F. and Wong B.C.Y., Inhibition of Akt/PKB by a COX-2 Inhibitor Induces Apoptosis in Gastric Cancer Cells, Digestion. 2006, 73(2-3): 75-83.

 

Fass R. and Wong B.C.Y., Non cardiac chest pain and proton pump inhibitors. (Letter), Archives of Internal Medicine. 2006, 166(2): 248-249.

 

Fischbach W., Chan O.O. and Wong B.C.Y., Helicobacter pylori and gastric malignancy, Helicobacter. 2005, 10 Suppl 1: 34-39.

 

Gu Q., Xia H.H.X., Wang J., Wong R.W.M., Chan O.O., Lai K.C., Chan C.K., Yuen R.M.F., Fung F.M.Y., Wong K.W., Lam S.K. and Wong B.C.Y., Update on clarithromycin resistance in Helicobacter pylori in Hong Kong and its effect on clarithromycin-based triple therapy., Digestion. 2006, 72(2-3): 101-106.

 

Gu Q., Xia H.H.X., Wang J., Chan O.O., Lai K.C., Fung F.M.Y., Wong K.W., Cheung K.L., Kung H. and Wong B.C.Y., Update on clarithromycin resistance in Helicobacter pylori in Hong Kong and its effect on clarithromycin-based triple therapy., In: Gu Q, Xia HHX, Wang JD, Chan AOO, Lai KC, Chan CK, Yuen MF, Fung FMY, Wong KW, Cheung HKL, H.F. Kung HF, B.C.Y. Wong BCY.. , J Gastroenterol Hepatol . 2005, 20 (Suppl.): A160.

 

He H., Xia H.H.X., Wang J., Gu Q., Lin M.C., Zou B., Lam S.K., Chan O.O., Yuen R.M.F., Kung H.F. and Wong B.C.Y., Inhibition of human telomerase reverse transcriptase by nonsteroidal antiinflammatory drugs in colon carcinoma, Cancer. 2006, 106(6): 1243-9.

 

Hui C.K., Cheung W., Au W.Y., Lie A.K.W., Zhang H., Yueng Y.H., Wong B.C.Y., Leung N., Kwong Y.L., Liang R.H.S. and Lau G., Hepatitis B reactivation after withdrawal of preemptive lamivudine in patients with hematological malignancy upon completion of cytotoxic chemotherapy, Liver International 2005. 2005, Oct: 182.

 

Hui C.K., Zhang H., Lee N.W., Lu L., Leung N., Wong B.C.Y., Lo C.M., Fan S.T., Luk J.M.C. and Lau G., Upregulation of toll-like receptor 7 is essential for serological clearance of hepatitis B surface antigen in chronic hepatitis B virus (HBV) infection, Liver International 2005. 2005, Oct: 196.

 

Jiang Y., Xia B., Jiang L., Lv M., Guo Q., Chen M., Li J., Xia H.H.X. and Wong B.C.Y., Association of CTLA-4 gene microsatellite polymorphism with ulcerative colitis in Chinese patients., Inflammatory bowel disease. 2006, 12(5): 369-373.

 

Kwong Y.L., Lau W.C.S., Ho S.L., Epstein R., Young R.T.T., Chan H.H.L., Tse H.F., Lam L., Chen W.H., Lee K.L.F., Ip M.S.M., Tsang K.W.T., Lam B., Tang S.C.W., Chan R.H.W., Lee S.W.L., Tan K.C.B., Yeung C.K., Chan D.T.M., Wong R.W.S., Choy C.B.Y., Wong B.C.Y., Li F.K., Lo W.K., Lui S.L., Cheung R.T.F., Mak W., Ho J.C.M., Mok T.M.Y., Kung A.W.C., Cheung B.M.Y., Chow W.S., Yuen R.M.F. and Wat N.M.S., In: Lau CP, Kumana CR, Lai CL, Lai KN, Lam KSL, Lam WK, Problem-Based Medical Case Management. Hong Kong, Hong Kong University Press, 2005.

 

Lai C.L., Chen S., Wong B.C.Y. and Yuen R.M.F., Gastroenterology and Hepatology., In: Lau CP, Chen MZ, Kumana CR, Lai CL, Lai KN, Lam KSL, Lam WK ed., Problem-Based Medical Cases Management. Hong Kong University Press, 2005, 75-107.

 

Lai K.C., Chu K.M., Hui W.M., Wong B.C.Y., Hu H.C., Wong W.M.R., Chan O.O.A., Wong J. and Lam S.K., Celecoxib compared with lansoprazole and naprosyn to prevent gastrointestinal ulcer complications, American Journal of Medicine. 2005, 118: 1271-1278.

 

Li G., Xia H.H.X., Chen M., Gu Q., Wang J., Peng J., Chan O.O., Cho C.H., So H.L., Lam S.K., Hu P.J., Liang Y.J., Lin H., Berg D.E., Feng Z.H., Langenback R. and Wong B.C.Y., Effects of Cyclooxygenase-1 and -2 Gene Disruption on Helicobacter pylori-Induced Inflammation, Journal of Infectious Diseases. 2006, 193(7): 1037-1046.

 

Lim P.W., Goh K.L. and Wong B.C.Y., CYP2C19 genotype and the PPIs – focus on rabeprazole, Journal of Gastroenterology and Hepatology. 2005, Suppl 3: S22-S28.

 

Liu C.L., Fan S.T., Lo C.M., Tso W.K., Wong Y., Poon R.T.P., Lam C.M., Wong B.C.Y. and Wong J., Clinicobiochemical prediction of biliary cause of acute pancreatitis in the era of endoscopic ultrasonography, Alimentary Pharmacology and Therapeutics. 2005, 22(5): 423-431.

 

Liu C.L., Fan S.T., Lo C.M., Tso W.K., Wong Y., Poon R.T.P., Lam C.M., Wong B.C.Y. and Wong J., Comparison of early endoscopic ultrasonography and endoscopic retrograde cholangiopancreatography in the management of acute biliary pancreatitis: a prospective randomized study, Clinical Gastroenterology and Hepatology. 2005, 3(12): 1238-1244.

 

Sun Y., Wang J., Xia H.H.X., Zou B., Lin M.C., Kung H. and Wong B.C.Y., Interferon-β-induced expression of XAF1 requires phosphorylation of STAT1 and a sequential activation of protein kinase C and JNK in colon cancer. Digestive Disease Week 2006, 20-25 May, Los Angeles, USA , Gastroenterology. 2006, 4 Suppl 2: A671.

 

Sun Y., Xia H.H.X., Zhu S., Zou B., Lin M.C., Kung H. and Wong B.C.Y., Novel interaction between xiap-associated factor 1 (XAF1) and nuclear coactivator CBP in colon cancer. Digestive Disease Week 2006, 20-25 May, Los Angeles, USA , Gastroenterology. 2006, 4 Suppl 2: A680.

 

Tang L.P., Cho C.H., Hui W.M., Huang F.Y., Lai C.L., Xia H.H.X., Lam S.K., Rashid A., Wong B.C.Y. and Chan O.O., A negative correlation between IL-6 and DNA methylation in patients with gastric cancer, Supplement to Gastroenterology - Digestive Disease Week and the 107th Annual Meeting of the American Gastroenterological Association Institute, May 20-25, 2006, Los Angeles, CA. 2006, 130:4 Suppl 2: A-717.

 

Wang J., Peng Y., Sun Y., He H., Zhu S., An X.M., Li M., Lin M.C., Zou B., Xia H.H.X., Jiang B., Chan O.O., Yuen R.M.F., Kung H.F. and Wong B.C.Y., All-Trans Retinoic Acid Induces XAF1 Expression Through an Interferon Regulatory Factor-1 Element in Colon Cancer, Gastroenterology. 2006, 130(3): 747-758.

 

Wang J., He H., Yu L., Xia H.H.X., Lin M.C., Gu Q., Li M., Zou B., An X.M., Jiang B., Kung H.F. and Wong B.C.Y., HSF1 down-regulates XAF1 through transcriptional regulation, Journal of Biological Chemistry. 2006, 281(5): 2451-2459.

 

Wang W., Huang J., Zheng G., Xia H.H.X., Wong R.W.M., Lam S.K. and Wong B.C.Y., Head-to-Head Comparison of H2-Receptor Antagonists and Proton Pump Inhibitors in the Treatment of Erosive Esophagitis: A Meta-Analysis, World Journal of Gastroenterology. 2005, 11(26): 4067-4077.

 

Wong B.C.Y., Assicuate Editor, since 2004, Digestive Disease Watch. 2006.

 

Wong B.C.Y., Associate Editor-in-chief, since 2002, Chinese Journal of Gastroenterology. 2006.

 

Wong B.C.Y., Chan O.O., Wong R.W.M., Hui W.M., Kung H. and Lam S.K., Attitudes and knowledge of colorectal cancer and screening in Hong Kong – A population-based study, Journal of Gastroenterology and Hepatology. 2006, 21(1 Pt 1): 41-46.

 

Wong B.C.Y., Balloon invasion benefits pateints with GI problems, Medical Tribune . 2005, Oct: viii.

 

Wong B.C.Y., Belching and gas, Mingpao weekly. 3 September. 2005, 110-113.

 

Wong B.C.Y., Can we prevent gastric cancer , Symposium “H pylori, gastritis and gastric cancer”, World Congress of Gastroenterology, Montreal Canada, 12 September. 2005.

 

Wong B.C.Y., Cancer chemoprevention, Next Magazine, 16 Mar. 2006, 118-119.

 

Wong B.C.Y., Chemoprevention of gastric cancer by eradication of H .pylori infection , 2005 Taipei Forum of Gastroenterology, Taipei, Taiwan, 1 October . 2005.

 

Wong B.C.Y., Chemoprevention of gastric cancer by eradication of Helicobacter pylori infection 2005 Autum Convention & Taipei Forum of Gastroenterology, Oct 1 2005, Taipei. , Gastroenterological Journal of Taiwan. 2005, 22:3: 260.

 

Wong B.C.Y., Colon cancer prevalence in female, Apple Daily, 9 June. 2006, A14.

 

Wong B.C.Y., Colon cancer survey, Press conference on behalf of Hong Kong Digestive Foundation, 6 October. Covered by ATV, Radio Television Hong Kong, and newspapers . 2005.

 

Wong B.C.Y., Common GI diseases, 最緊要健康, TVB Jade, 7pm, 16 June, 2006.

 

Wong B.C.Y., Common GI diseases , Joint dinner meeting of Lions Club of Hong Kong (Host), Lions Club of Kwun Tong, Lions Club of Hong Kong Island, Lions Club of Silverstrand, Lions Club of Red Hill, and Lions Club of Pearl Harbour, Conrad Hotel, 17 March. 2006.

 

Wong B.C.Y., Common Gastrointestinal diseases, Seminar, Chinese General Chamber of Commerce, 4 July . 2005.

 

Wong B.C.Y., Common gastrointestinal diseses , Lunch symposium, Hong Kong Oriental Lions Club meeting, Grand Hyatt Hotel, Hong Kong, 10 January. 2006.

 

Wong B.C.Y., Common gastrointestinal diseses , Luncheon symposium, City Lions Club of Hong Kong, Conrad Hotel, Hong Kong, 8 November. 2005.

 

Wong B.C.Y., Common gastrointestinal diseses , Luncheon symposium, Lions Club of Hong Kong East, Miramar Hotel, Hong Kong, 2 December. 2005.

 

Wong B.C.Y., Common gastrointestinal diseses , Luncheon symposium, Rotary Club of the Peak, China Club, Hong Kong, 1 Nov. 2005.

 

Wong B.C.Y., Constipation, Hong Kong Economic Times, 12 July. 2005, A17.

 

Wong B.C.Y., Diagnosis and Management of liver diseases, Dinner talk at Chinese General Chamber of Commerce, 9 May . 2006.

 

Wong B.C.Y., Diagnostic tests for Helicobacter pylori, Next Magazine, 20 Apr. 2006, 120.

 

Wong B.C.Y., Diet and GI diseases , Digestive Health Awareness Coalition Program for the Family Planning Association of HK (FPA), Ma On Shan, Hong Kong, 1 April. 2006.

 

Wong B.C.Y., Diet and GI diseases, Digestive Health Awareness Coalition Program for the Family Planning Association of HK (FPA), Sheung Shui Women Club of FPA, 4 October, 2005. 2005.

 

Wong B.C.Y., Diet and GI diseases, HK Economy Times, 25 Apr. 2006, C11.

 

Wong B.C.Y., Difficulties in colon cancer screening in Hong Kong., Proceedings, 2005 Internatoina Asian Conference of Cancer Screening, Nov 21-22, 2005, Tapiei, Taiwan. 2005, 102-103.

 

Wong B.C.Y., Difficulties in colon cancer screening in Hong Kong, Second International Asian Conference of Cancer Screening, Taipei, Taiwan, 22 November . 2005.

 

Wong B.C.Y., Double Balloon Enteroscopy, CME program at St Teresa’s Hospital, Hong Kong, 11 December . 2005.

 

Wong B.C.Y., Double balloon enteroscopy, Health program, Metro FM104, 4:00-5:00pm, 6 Aug. 2005.

 

Wong B.C.Y., Dyspepsia is not a universal diagnosis for patients with epigastric pain , Proceedings: 11th Hong Kong Medical Forum, Hong Kong Convention & Exhibition Center, 3-4 June 2006, Hong Kong. 2006, 18.

 

Wong B.C.Y. and Wong B.C.Y., Dyspepsia is not a universal diagnosis for patients with epigastric pain , 11th Hong Kong Medical Forum, Convention Center, Hong Kong, 3 June. 2006.

 

Wong B.C.Y., Dyspepsia is not a universal diagnosis for patients with epigastric pain , 11th Hong Kong-China Medical Forum, Guangzhou, PR China, 6 June. 2006.

 

Wong B.C.Y., Editor, since 2003, Journal of Gastroenterology and Hepatology. 2006.

 

Wong B.C.Y., Editorial Board, since 2001, Digestive Endoscopy. 2006.

 

Wong B.C.Y., Editorial Board, since 1999, Chinese Journal of Gastroenterology. 2006.

 

Wong B.C.Y., Editorial Board, since 1999, Journal of Clinical Oncology - Chinese edition. 2006.

 

Wong B.C.Y., Editorial Board, since 2000, Journal of Gastroenterology and Hepatology. 2006.

 

Wong B.C.Y., Editorial Board, since 2002, Chinese Journal of Digestive Diseases. 2006.

 

Wong B.C.Y., Editorial Board, since 2002, MIMS Gastroenterology. 2006.

 

Wong B.C.Y., Editorial Board, since 2003, Modern Digestion and Intervention. 2006.

 

Wong B.C.Y., Editorial Board, since 2004, Alimentary Pharmacology and Therapeutics. 2006.

 

Wong B.C.Y., Editorial Board, since 2004, European Review for Medical and Pharmacological Sciences. 2006.

 

Wong B.C.Y., Editorial Board, since 2004, Gastrointestinal Endoscopy. 2006.

 

Wong B.C.Y., Editorial Board, since 2004, World Journal of Gastroenterology. 2006.

 

Wong B.C.Y., Editorial Board, since 2005, Carcinogenesis. 2006.

 

Wong B.C.Y., Epidemiology of Reflux Disease , Astrazeneca symposium “The leading edge of reflux disease”, World Congress of Gastroenterology, Montreal Canada, 12 September, 2005 . 2005.

 

Wong B.C.Y., Eradication of Helicobacter pylori to prevent gastric cancer , International Gastroenterology Conference, Shanghai, China, 8 July . 2005.

 

Wong B.C.Y., Eradication of Helicobacter pylori to prevent gastric cancer, Proceedings, 5th Shanghai International Conference of Gastroenterology, 7-9 July 2005, Shanghai, PR China . 2005, 81.

 

Wong B.C.Y., Female GERD risk factors, SingPao, 2 June. 2006, A09.

 

Wong B.C.Y., Food poisoning, Headline Daily, 26 Jan. 2006, 2.

 

Wong B.C.Y., GERD affects Hong Kong people, Oriental Daily, 2 April. 2006, A7.

 

Wong B.C.Y., GERD in Asia, 3rd Beijing International Digestive Disease Forum, PR China, 27 May . 2006.

 

Wong B.C.Y., GERD inflicts more than physical stress, Medical Tribune. 2006, Apr: 11.

 

Wong B.C.Y., Gastritis in Hong Kong, SingTao Daily, 16 June. 2006, A10.

 

Wong B.C.Y., Gastritis., Sudden Weekly Magazine, 30 June. 2006, 162.

 

Wong B.C.Y., Gastro-esophageal reflux diseases: Impact on quality of life , 5th FAST expert panel meeting, Tokyo, Japan, 10 June 2006 . 2006.

 

Wong B.C.Y., Gastroenteritis and appendicitis, Oriental Daily, 14 Nov . 2005, A24.

 

Wong B.C.Y., Gastroenteritis and appendicitis, Sun Newspaper, 14 Nov . 2005, A14.

 

Wong B.C.Y., Wong R.W.M. and Smales R.J., Gastroesophageal reflux disease and tooth erosion. Edited by: Yip KHK, Smales RJ, Kaidonis JA , In: Tooth Erosion: Prevention and Treatment. . New Delhi, India, Jaypee Brothers Medical Publishers Ltd, 2006, 47-55.

 

Wong B.C.Y., Gastroesophageal reflux disease, Hong Kong Economic Times, 26 Jan. 2006, A30.

 

Wong B.C.Y., Helicobacter pylori Infection and peptic ulcers , Ma On Shan District Elderly Community Centre, Kam Tai Court, Ma On Shan, 14 October. 2005.

 

Wong B.C.Y., Helicobacter pylori, Oriental Daily, 10 September. 2005, A20.

 

Wong B.C.Y., Helicobacter pylori and peptic ulcers, Mingpao Newspaper, 1 Dec. 2005, G3.

 

Wong B.C.Y., Helicobacter pylori prevention, Sun Newspaper, 21 Dec 2005. 2005, S5.

 

Wong B.C.Y., Helicobacter pylori., AM730, 4 October. 2005, 1.

 

Wong B.C.Y., Helicobacter pylori, Oriental Daily, 4 October. 2005, A10.

 

Wong B.C.Y., Introduction, Journal of Gastroenterology and Hepatology. 2005, Suppl 3: S1.

 

Wong B.C.Y., NSAID can cause peptic ulcer, Sun Daily, 16 June. 2006, A28.

 

Wong B.C.Y., NSAID-induced gastritis, Apple Daily, 16 June. 2006, A17.

 

Wong B.C.Y., New Imaging Technique for colon cancer screening , 12th Hong Kong International Cancer Congress, Hong Kong, 9 December. 2005.

 

Wong B.C.Y., Non cardiac chest pain , Functional GI Research Forum, GIHep Singapore 2006, 26 Feb, Singapore. 2006.

 

Wong B.C.Y., Novel endoscopic method for diagnosis and treatment of small intestinal diseases, Press conference, 3 August. Covered by electronic media (TV, radio) and all major newspapers. 2005.

 

Wong B.C.Y., PPI Failure/ Resistance – Mechanisms & Solutions, 4th FAST expert panel meeting, Eisia Co Ltd, Bangkok, Thailand, 26 Nov 2005. 2005.

 

Wong B.C.Y., Peptic Ulcer & Helicobacter pylori Infection , Digestive Health Awareness Coalition Program, Hong Kong Digestive Foundation, for the Family Planning Association of HK (FPA), FPA auditorium, Wanchai, Hong Kong, 9 September. 2005.

 

Wong B.C.Y., Perspectives of gastric cancer from Asia, Canadian Helicobacter Study Group post-WCOG meeting, Montreal, Canada, 15 September. 2005.

 

Wong B.C.Y., Prevention of Digestive Cancers: Kill the bug or take the drug , Annual General Meeting of Hong Kong Pharmacology Society, 8 December. 2005.

 

Wong B.C.Y., Prevention of NSAID gastropathy, GIHep Singapore 2006, 26 February, Singapore. 2006.

 

Wong B.C.Y., Prevention of colon cancer, Oriental Daily, 22 September . 2005, S2.

 

Wong B.C.Y., Prolonged fasting in wilderness, Singtao Daily, 20 Feb. 2006, A4.

 

Wong B.C.Y., Randomized trials in China , Proceedings, International Symposium of 92nd Annual Meeting of Japanese Society of Gastroenterology, April 20-21, 2006. 4 Suppl 2: A717.

 

Wong B.C.Y., Randomized trials in China, Symposium: Prevention of 92nd Annual scientific meeting of Japanese Society of Gastroenterology, Kikura, Japan, 20 April . 2006.

 

Wong B.C.Y., Risk factors for colon cancer, Oriental Daily, 12 July. 2005, A24.

 

Wong B.C.Y., Role of Helicobacter pylori and non steroidal anti-inflammatory drugs in prevention of gastric cancer, PhD thesis. Hong Kong, 2005, 1-178.

 

Wong B.C.Y., Stress and gastrointestinal diseses , Dinner symposium, Lions Club of Hong Kong Zone 10 joint meeting, Miramar Hotel, Hong Kong, 10 January, 2006. 2006.

 

Wong B.C.Y., Survival after prolonged fasting, Headline Daily, 20 Feb. 2006, 1.

 

Wong B.C.Y. and Kinoshita Y., Systematic review on epidemiology of gastro-oesophageal reflux disease in Asia., Clnical Gastroenterology & Hepatology. 2006, 4: 398-407.

 

Wong B.C.Y., Targeted therapies for gastrointestinal cancers, 10th Medical Forum, Department of Medicine, University of Hong Kong, 17 July. 2005.

 

Wong B.C.Y., Targeted therapies in gastrointestinal cancer, Proceedings, 10th Hong Kong Medical Forum, Department of Medicine, University of Hong Kong, 17 July 2005, Hong Kong. 2005, 26.

 

Wong B.C.Y., Update on screening and treatment of colon cancer, CME program at St Teresa’s Hospital, Hong Kong, April 2, 2006. 2006.

 

Wong B.C.Y., Use of intravenous proton pump inhibitor in acid related diseases, Round Table Discussion, Tan Tock Seng Hospital, 25 February, Singapore. 2006.

 

Wong B.C.Y., olon cancer drug trials in Hong Kong, HK Economy Times, 16 Feb. 2006, A29.

 

Wong W.M.R., Gu Q., Chu K.M., Yee Y.K., Fung F.M.Y., Tong S.M., Chan O.O.A., Lai K.C., Chan C.K. and Wong B.C.Y., Lansoprazole, levofloxacin and amoxicillin triple therapy versus quadruple therapy as second-line treatment of resistant Helicobacter pylori infection, Alimentary Pharmacology & Therapeutics. 2006, 23: 421-427.

 

Xia B., Xia H.H.X., Ma C.W., Wong K.W., Fung F.M.Y., Hui C.K., Chan C.K., Chan O.O., Lai K.C., Yuen R.M.F. and Wong B.C.Y., Trends in the prevalence of peptic ulcer disease and Helicobacter pylori infection in family physician-referred uninvestigated dyspeptic patients in Hong Kong. , Alimentary Pharmacology and Therapeutics. 2005, 22(3): 243-9.

 

Xia H.H.X., He H., Wang J., Gu Q., Lin M.C., Zou B., Yu L., Sun Y., Chan O.O., Kung H.F. and Wong B.C.Y., Induction of apoptosis and cell cycle arrest by a specific c-Jun NH(2)-terminal kinase (JNK) inhibitor, SP-600125, in gastrointestinal cancers., Cancer Letters. 2005, 241(2): 268-74.

 

Xia H.H.X., Wong R.W.M., Chan O.O., Lam S.K., Lai K.C., Chan C.K., Cheung K.L., Fung F.M.Y., Wong K.W. and Wong B.C.Y., Natural acquisition of Helicobacter pylori in adult dyspeptic patients with or without previous infection – a 7-year follow-up study. Australian Gastroenterology Week 2005, 19 October 2005, Australia. , Journal of Gastroenterology and Hepatology. 2005, 20: Supp A112.

 

Yeung Y.P., Lo C.M., Liu C.L., Wong B.C.Y., Fan S.T. and Wong J., Natural history of untreated nonsurgical hepatocellular carcinoma, American Journal of Gastroenterology. 2005, 100(9): 1995-2004.

 

Yu L., Wang J., Zou B., Lin M.C., Wu Y.L. and Wong B.C.Y., Sulindac Metabolites Induces XAF1 Expression by Inhibition of Extracellular Signal-regulated Kinase 1/2 Phosphorylation in Human Gastric Cancer Cells. Oral presentation, Asian Pacific Digestive Week 2005, Sept. 25-28, 2005, Seoul, Korea , Journal of Gastroenterology and Hepatology. 2005, 20: Supp A299.

 

Yu L., Wang J., Zou B., Wu Y.L. and Wong B.C.Y., XAF1 mediates inhibition of extracellular signal-regulated kinase 1/2 induced apoptosis in human colon cancer cells. Digestive Disease Week 2006, 20-25 May, Los Angeles, USA , Gastroenterology. 2006, 4 Suppl 2: A531.

 

Yuen R.M.F., Yuan H., Wong D.K.H., Yuen J.C.H., Wong R.W.M., Chan O.O., Wong B.C.Y., Lai K.C. and Lai C.L., Prognostic determinants for chronic hepatitis B in Asians: therapeutic implications. , Gut. 2005, 54(11): 1610-4.

 

Yuen R.M.F., Sablon E., Libbrecht E., Van de Velde H., Wong D.K.H., Fung J.Y.Y., Wong B.C.Y. and Lai C.L., Significance of HBV DNA, core promoter/precore mutations, genotypes, specific sequences of polymerase gene on three-year lamivudine treatment: A predictive model for antiviral therapy, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2006, 44 (Suppl 2): S194.

 

Zou B., Chim J.C.S., Lin M.C., Zeng H., He H., Yu L., Sun Y., Jiang S.H. and Wong B.C.Y., Correlation between the single-site CpG mutation within the gene promoter and the expression silencing of XIAP -Associated Factor 1 (XAF1) in human colon cancer cell lines. Asian Pacific Digestive Week, Sept. 25-28, 2005, Seoul, Korea., Journal of Gastroenterology and Hepatology. 2005, 20: Supp A253.

 

Zou B., Chim J.C.S., Lin M.C., Zeng H., He H., Yu L., Sun Y., Jiang S.H. and Wong B.C.Y., Distinguished Poster Award, "Correlation between the single-site CpG mutation within the gene promoter and the expression silencing of XIAP -Associated Factor 1 (XAF1) in human colon cancer cell lines" , Asian Pacific Digestive Week, Sept. 25-28, Seoul, Korea. 2005.

 

Zou B., Lin M.C., Lam S.K., Tu S., Zeng H., Yang Y., Wang J., He H., Jiang S.H., Kung H. and Wong B.C.Y., Distinguished Poster Award, "Hypermethylation status around exon 1 of XIAP-Associated Factor 1(XAF1) in human gastric and colon cancer cell line.", Asian Pacific Digestive Week, Sept. 25-28, Seoul, Korea.. 2005.

 

Zou B., Lin M.C., Lam S.K., Tu S., Zeng H., Yang Y., Wang J., He H., Jiang S.H., Kung H. and Wong B.C.Y., Hypermethylation status around exon 1 of XIAP-Associated Factor 1(XAF1) in human gastric and colon cancer cell line. Asian Pacific Digestive Week, Sept. 25-28, 2005, Seoul, Korea. , Journal of Gastroenterology and Hepatology. 2005, 20: Supp A370.

 

Researcher : Wong CP



List of Research Outputs

 

Wong C.P., Chiu P.K.C. and Chu L.W., Zoplicone withdrawal-an unusual cause of delirium in elderly., Age Ageing. 2005, 34: 526-527.

 

Researcher : Wong CW



List of Research Outputs

 

Wang K., Xue T., Tsang S.Y., Huizen R.V., Wong C.W., Lai K.W.H., Ye Z., Cheng L., Zhang J.C.L., Li G.R., Lau C.P., Tse H.F. and Li R.A., Electrophysiological Properties of Pluripotent Human and Mouse Embryonic Stem Cells, Stem Cells. 2005, 23: 1526-1534.

 

Researcher : Wong DKH



List of Research Outputs

 

Sum S.M., Wong D.K.H., Yuen J.C.H., Lai C.L. and Yuen R.M.F., Comparison of the COBAS TaqMan HBV Test with the COBAS Amplicor Monitor Test for Measurement of Hepatitis B Virus DNA in Serum, Journal of Medical Virology. 2005, 77: 486-490.

 

Wong D.K.H., Yuen R.M.F., Tanaka Y., Lai C.L., Kwok C.L. and Mizokami M., Correlation between Hepatitis B virus core-related antigens and intrahepatic covalently closed circular DNA levels, Hepatology. 2005, 42 (Suppl 1): 712A.

 

Wong D.K.H., Tanaka Y., Lai C.L., Mizokami M. and Yuen R.M.F., Detection of hepatitis B virus core-related antigens as a marker for the monitoring of viral activity during nucleoside analogue therapy, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2006, 44 (Suppl 2): S192.

 

Wong D.K.H., Yuen R.M.F., Ngai W.S. and Lai C.L., One-year treatment of entecavir results in reduction in intrahepatic covalently closed circular DNA level, Hepatology. 2005, 42(Suppl 1): 573A.

 

Yuan H., Yuen R.M.F., Wong D.K.H., Sum S.M., Sablon E., Ng I.O.L. and Lai C.L., Impact of Precore and Core Promoter Mutations on Hepatic Histology in Patients with Chronic Hepatitis B, Alimentary Pharmacology and Therapeutics. 2005, 22: 301-307.

 

Yuan H.J., Yuen R.M.F., Wong D.K.H., Sablon E. and Lai C.L., The relationship between HBV-DNA levels and cirrhosis-related complications in Chinese with chronic hepatitis B, Journal of Viral Hepatitis. 2005, 12: 373-379.

 

Yuen R.M.F., Tanaka Y., Ng I.O.L., Mizokami M., Yuen J.C.H., Wong D.K.H., Yuan H., Sum S.M., Chan O.O. and Lai C.L., Hepatic necroinflammation and fibrosis in patients with genotypes Ba and C, core-promoter and precore mutations, Journal of Viral Hepatitis . 2005, 12(5): 513-8.

 

Yuen R.M.F., Wong D.K.H., Chan C.C.S., Zheng B.J., Yuen J.C.H. and Lai C.L., Immune response during immunoclearance phase of Chinese patients with HBV genotypes B and C., Journal of hepatology : the journal of the European Association for the Study of the Liver. 2005, 42 (Suppl 2): 152.

 

Yuen R.M.F., Seto W.K., Chow D.H.F., Tsui K., Wong D.K.H., Chan P., But D. and Lai C.L., Long-term beneficial outcome of Chinese asymptomatic patients with HBeAg-positive chronic hepatitis B on continuous lamivudine therapy: 7-year experience., Hepatology. 2005, 42 (4 Suppl 1): 583A.

 

Yuen R.M.F., Yuan H., Wong D.K.H., Yuen J.C.H., Wong R.W.M., Chan O.O., Wong B.C.Y., Lai K.C. and Lai C.L., Prognostic determinants for chronic hepatitis B in Asians: therapeutic implications. , Gut. 2005, 54(11): 1610-4.

 

Yuen R.M.F., Sablon E., Libbrecht E., Van de Velde H., Wong D.K.H., Fung J.Y.Y., Wong B.C.Y. and Lai C.L., Significance of HBV DNA, core promoter/precore mutations, genotypes, specific sequences of polymerase gene on three-year lamivudine treatment: A predictive model for antiviral therapy, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2006, 44 (Suppl 2): S194.

 

Researcher : Wong KW



List of Research Outputs

 

Gu Q., Xia H.H.X., Wang J., Wong R.W.M., Chan O.O., Lai K.C., Chan C.K., Yuen R.M.F., Fung F.M.Y., Wong K.W., Lam S.K. and Wong B.C.Y., Update on clarithromycin resistance in Helicobacter pylori in Hong Kong and its effect on clarithromycin-based triple therapy., Digestion. 2006, 72(2-3): 101-106.

 

Gu Q., Xia H.H.X., Wang J., Chan O.O., Lai K.C., Fung F.M.Y., Wong K.W., Cheung K.L., Kung H. and Wong B.C.Y., Update on clarithromycin resistance in Helicobacter pylori in Hong Kong and its effect on clarithromycin-based triple therapy., In: Gu Q, Xia HHX, Wang JD, Chan AOO, Lai KC, Chan CK, Yuen MF, Fung FMY, Wong KW, Cheung HKL, H.F. Kung HF, B.C.Y. Wong BCY.. , J Gastroenterol Hepatol . 2005, 20 (Suppl.): A160.

 

Xia B., Xia H.H.X., Ma C.W., Wong K.W., Fung F.M.Y., Hui C.K., Chan C.K., Chan O.O., Lai K.C., Yuen R.M.F. and Wong B.C.Y., Trends in the prevalence of peptic ulcer disease and Helicobacter pylori infection in family physician-referred uninvestigated dyspeptic patients in Hong Kong. , Alimentary Pharmacology and Therapeutics. 2005, 22(3): 243-9.

 

Xia H.H.X., Wong R.W.M., Chan O.O., Lam S.K., Lai K.C., Chan C.K., Cheung K.L., Fung F.M.Y., Wong K.W. and Wong B.C.Y., Natural acquisition of Helicobacter pylori in adult dyspeptic patients with or without previous infection – a 7-year follow-up study. Australian Gastroenterology Week 2005, 19 October 2005, Australia. , Journal of Gastroenterology and Hepatology. 2005, 20: Supp A112.

 

Researcher : Wong LC



List of Research Outputs

 

Chen B., Lam K.S.L., Wang Y., Wu D., Lam C.W., Shen J., Wong L.C., Hoo R.L.C., Zhang J. and Xu A., Hypoxia dysregulates the production of adiponectin and plasminogen activator inhibitor-1 independent of reactive oxygen species in adipocytes, Biochem Biophys Res Commun. 2006, 341: 549-56.

 

Researcher : Wong LYF



Project Title:

Involvement of NF-κB and cAMP-dependent protein kinase pathways in adrenomedullin-induced cytokine responses in macrophages

Investigator(s):

Wong LYF, Cheung BMY

Department:

Medicine

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

 

Abstract:

To assess the involvement of NF-[kappa]B pathway as the link between AM and inflammation; to confirm that AM exerts its effect on cytokine production in macrophages through cyclic-AMP; to identify the cAMP-dependent protein kinase pathway involved in the AM-induced cytokine response in LPS-stimulated macrophages.

 

List of Research Outputs

 

Cheung B.M.Y., Leung R.Y.H., Man Y.B., Ong K.L., Wong L.Y.F., Lau C.P. and Lam K.S.L., Association of hypertension with single nucleotide polymorphisms in the quantitative trait locus for abdominal obesity-metabolic syndrome on chromosome 17, J Hum Hyperten. 2006.

 

Li Y.Y., Cheung B.M.Y., Wong L.Y.F., Hwang I.S.S., Kumana C.R. and Tang F., Adrenomedullin gene expression and levels in the cardiovascular system after treatment with lipopolysaccharide, Neuropeptides. 2005, 39: 73-80.

 

Li Y.Y., Wong L.Y.F., Cheung B.M.Y., Hwang I.S.S. and Tang F., Differential Induction of Adrenomedullin, Interleukins and Tumour Necrosis Factor-aby Lipopolysaccharide in Rat Tissues in Vivo, Clinical and Experimental Pharmacology and Physiology. Australia, Blackwell Science Asia, 2005, 32(12): 1110-1118.

 

Li Y.Y., Wong L.Y.F., Cheung B.M.Y., Hwang I.S.S. and Tang F., Differential induction of adrenomedullin, interleukins and tumour necrosis factor-alpha by lipopolysaccharide in rat tissues in vivo. , Clinical and Experimental Pharmacology and Physiology. 2005, 32: 1110-1118.

 

Researcher : Wong MS



List of Research Outputs

 

Chan K., Sasanakul W., Mellars G., Chuansumrit A., Perry D., Lee C.A., Wong M.S., Chan T.K. and Chan V.N.Y., Detection Of Known Haemophilia B Mutations And Carrier Testing By Microarray., Thrombosis and Haemostasis.. 2005, 94: 872-878.

 

Researcher : Wong PC



List of Research Outputs

 

Lam B., Wong M.P., Fung S.L., Lam D.C.L., Wong P.C., Mok T.Y.W., Lam F.M., Ip M.S.M., Ooi C.G.C. and Lam W.K., The clinical value of autofluorescence bronchoscopy for the diagnosis of lung cancer, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2006, Abstract Book 094: pp. 58.

 

Researcher : Wong RWM


Project Title:

Non-cardiac chest pain in Chinese population

Investigator(s):

Wong RWM, Lam SK, Wong BCY

Department:

Medicine

Source(s) of Funding:

Merit Award for RGC CERG Funded Projects

Start Date:

12/2003

 

Abstract:

N/A

 

List of Research Outputs

 

Chan O.O., Hui W.M., Chan C.K., Lai K.C., Hu H.C., Yuen R.M.F., Wong R.W.M., Lau G., Hui C.K., Lam S.K. and Wong B.C.Y., Colonoscopy Demand and Practice in a Regional Hospital over 9 Years in Hong Kong: Resource Implication for Cancer Screening, Gastroenterology. 2006, 130 (4 Suppl 2): A-618.

 

Chan O.O., Hui W.M., Chan C.K., Lai K.C., Hu H.C., Yuen R.M.F., Wong R.W.M., Lau G., Hui C.K., Lam S.K. and Wong B.C.Y., Colonoscopy demand and practice in a regional hospital over 9 years in Hong Kong: Resource implication for cancer screening, Digestion. 2006, 73(2-3): 84-88.

 

Chan O.O., Cheng C., Hui W.M., Hu H.C., Wong Y.H., Lam K.F., Wong R.W.M., Lai K.C., Lam S.K. and Wong B.C.Y., Differing coping mechanisms, stress level and anorectal physiology in patients with functional constipation, World Journal of Gastroenterology. The WJG Press and Elsevier Inc., 2005, 11(34): 5362-5366.

 

Chan O.O., Chu K.M., Lam S.K., Cheung K.L., Law S.Y.K., Kwok K.F., Wong R.W.M., Yuen R.M.F. and Wong B.C.Y., Early prediction of tumor recurrence after curative resection of gastric carcinoma by measuring soluble E-cadherin, Cancer. 2005, 104(4): 740-6.

 

Gu Q., Xia H.H.X., Wang J., Wong R.W.M., Chan O.O., Lai K.C., Chan C.K., Yuen R.M.F., Fung F.M.Y., Wong K.W., Lam S.K. and Wong B.C.Y., Update on clarithromycin resistance in Helicobacter pylori in Hong Kong and its effect on clarithromycin-based triple therapy., Digestion. 2006, 72(2-3): 101-106.

 

Ng W., Wong R.W.M., Chen W.H., Tse H.F., Lee P.Y., Lai K.C., Li L.S.W., Ng M.M.T., Lam K.F., Cheng X. and Lau C.P., Incidence and predictors of upper gastrointestinal bleeding in patients receiving low-dose aspirin for secondary prevention of cardiovascular events in patients with coronary artery disease, World Journal of Gastroenterology. Beijing, China, The WJG Press, 2006, 12(18): 2923-2927.

 

Wang W., Huang J., Zheng G., Xia H.H.X., Wong R.W.M., Lam S.K. and Wong B.C.Y., Head-to-Head Comparison of H2-Receptor Antagonists and Proton Pump Inhibitors in the Treatment of Erosive Esophagitis: A Meta-Analysis, World Journal of Gastroenterology. 2005, 11(26): 4067-4077.

 

Wong B.C.Y., Chan O.O., Wong R.W.M., Hui W.M., Kung H. and Lam S.K., Attitudes and knowledge of colorectal cancer and screening in Hong Kong – A population-based study, Journal of Gastroenterology and Hepatology. 2006, 21(1 Pt 1): 41-46.

 

Wong B.C.Y., Wong R.W.M. and Smales R.J., Gastroesophageal reflux disease and tooth erosion. Edited by: Yip KHK, Smales RJ, Kaidonis JA , In: Tooth Erosion: Prevention and Treatment. . New Delhi, India, Jaypee Brothers Medical Publishers Ltd, 2006, 47-55.

 

Xia H.H.X., Wong R.W.M., Chan O.O., Lam S.K., Lai K.C., Chan C.K., Cheung K.L., Fung F.M.Y., Wong K.W. and Wong B.C.Y., Natural acquisition of Helicobacter pylori in adult dyspeptic patients with or without previous infection – a 7-year follow-up study. Australian Gastroenterology Week 2005, 19 October 2005, Australia. , Journal of Gastroenterology and Hepatology. 2005, 20: Supp A112.

 

Yuen R.M.F., Yuan H., Wong D.K.H., Yuen J.C.H., Wong R.W.M., Chan O.O., Wong B.C.Y., Lai K.C. and Lai C.L., Prognostic determinants for chronic hepatitis B in Asians: therapeutic implications. , Gut. 2005, 54(11): 1610-4.

 

Researcher : Wong RWS



List of Research Outputs

 

Kwong Y.L., Lau W.C.S., Ho S.L., Epstein R., Young R.T.T., Chan H.H.L., Tse H.F., Lam L., Chen W.H., Lee K.L.F., Ip M.S.M., Tsang K.W.T., Lam B., Tang S.C.W., Chan R.H.W., Lee S.W.L., Tan K.C.B., Yeung C.K., Chan D.T.M., Wong R.W.S., Choy C.B.Y., Wong B.C.Y., Li F.K., Lo W.K., Lui S.L., Cheung R.T.F., Mak W., Ho J.C.M., Mok T.M.Y., Kung A.W.C., Cheung B.M.Y., Chow W.S., Yuen R.M.F. and Wat N.M.S., In: Lau CP, Kumana CR, Lai CL, Lai KN, Lam KSL, Lam WK, Problem-Based Medical Case Management. Hong Kong, Hong Kong University Press, 2005.

 

Mok T.M.Y., Wong S.Y., Chan D.T.M., Tang W.M., Wong R.W.S. and Lau W.C.S., Necrotising Fasciitis in Rheumatic Diseases, Lupus. 2006, 15: 380-3.

 

Researcher : Wong SY



List of Research Outputs

 

Mok T.M.Y., Wong S.Y., Chan D.T.M., Tang W.M., Wong R.W.S. and Lau W.C.S., Necrotising Fasciitis in Rheumatic Diseases, Lupus. 2006, 15: 380-3.

 

Researcher : Wong W



List of Research Outputs

 

Wong W., The content validity of Chinese Quality of Life instrument in Hong Kong., Quality of Life Research in Asia. Hong Kong, 2006.

 

Wong W., Traditional Chinese Medicine Policy in Hong Kong., 2nd Runner up in the competition for the 2005/06 Hong Kong Public Policy Innovation Award: Strategies for Sustainable Development in Hong Kong. Young Adults Section. The Hong Kong Federation of Youth Groups. 2006.

 

Researcher : Wong WM



Project Title:

Non-cardiac chest pain in Chinese population

Investigator(s):

Wong RWM, Lam SK, Wong BCY

Department:

Medicine

Source(s) of Funding:

Merit Award for RGC CERG Funded Projects

Start Date:

12/2003

 

Abstract:

N/A

 

List of Research Outputs

 

Researcher : Wong WMR



List of Research Outputs

 

Lai K.C., Chu K.M., Hui W.M., Wong B.C.Y., Hu H.C., Wong W.M.R., Chan O.O.A., Wong J. and Lam S.K., Celecoxib compared with lansoprazole and naprosyn to prevent gastrointestinal ulcer complications, American Journal of Medicine. 2005, 118: 1271-1278.

 

Wong W.M.R., Gu Q., Chu K.M., Yee Y.K., Fung F.M.Y., Tong S.M., Chan O.O.A., Lai K.C., Chan C.K. and Wong B.C.Y., Lansoprazole, levofloxacin and amoxicillin triple therapy versus quadruple therapy as second-line treatment of resistant Helicobacter pylori infection, Alimentary Pharmacology & Therapeutics. 2006, 23: 421-427.

 

Researcher : Wong WS



List of Research Outputs

 

Kwok J.S.Y., Hui K.H., Lee T.L., Wong W.H.S., Lau Y.L., Wong W.S., Kim D.L. and Jones B.M., Anti-cyclic citrullinated peptide: diagnostic and prognostic values in juvenile idiopathic arthritis and rheumatoid arthritis in a Chinese population, Scandinavian Journal of Rheumatology. 2005, 34(5): 359-366.

 

Researcher : Wong Y



List of Research Outputs

 

Lee K.K., Shiu S.W.M., Wong Y., Wong W.K. and Tam S., Plasma apolipoprotein E is a major determinant of phospholipid transfer protein activity in type 2 diabetes mellitus, The 6th International Diabetes Federation Western Pacific Region Congress, Bangkok, Oct 2005.

 

Tan K.C.B., Shiu S.W.M., Wong Y., Wong W.K. and Tam S., Plasma apolipoprotein E concentration is an important determinant of phospholipid transfer protein activiity in type 2 diabetes mellitus, Diabetes Metab Res Rev. 2006.

 

Zhou H., Shiu S.W.M., Wong Y. and Tan K.C.B., Association between advanced glycation end products and reduced activity of HDL to protect LDL against oxidation in type 2 diabetes mellitus, American Diabetes Association 66th Scientific Sessions, Washington. 2006.

 

Zhou H., Shiu S.W.M., Wong Y. and Tan K.C.B., Decreased activity of HDL to protect LDL against oxidation in type 2 diabetic patients with nephropathy, 5th Congress of Asian Pacific Society of Atherosclerosis and Vascular Diseases. 2006.

 

Zhou H., Shiu S.W.M., Wong Y. and Tan K.C.B., HDL dysfunction in type 2 diabetic patients with nephropathy, International Symposium on Healthy Aging, Hong Kong. 2006.

 

Researcher : Wong YH



List of Research Outputs

 

Chan O.O., Cheng C., Hui W.M., Hu H.C., Wong Y.H., Lam K.F., Wong R.W.M., Lai K.C., Lam S.K. and Wong B.C.Y., Differing coping mechanisms, stress level and anorectal physiology in patients with functional constipation, World Journal of Gastroenterology. The WJG Press and Elsevier Inc., 2005, 11(34): 5362-5366.

 

Researcher : Wu AYY



List of Research Outputs

 

Ma L., Chan K.W., Trendell-Smith N.J., Wu A.Y.Y., Tian L., Lam A.C., Lo C.K., Chik S.C.C., Ko K.H., To K.W., Kam C.S.K., Li X., Yang C., Leung S.Y., Ng M.H. and Huang F., Systemic autoimmune disease induced by dendritic cells that have captured necrotic but not apoptotic cells in susceptible mouse strains, In: Ma L, Chan KW, Trendell-Smith NJ, Wu A, Tian L, Lam AC, Chan AK, Lo CK, Chik S, Ko KH, To CK, Kam SK, Li XS, Yang CH, Leung SY, Ng MH, Stott DI, MacPherson GG, Huang FP, European Journal of Immunology (In This Issue highlight, Editorial Comments). 2005, 35(11): 3364-75.

 

Researcher : Xia HHX



Project Title:

Homeobox genes in gastric carcinogenesis: an in vivo and in vitro study

Investigator(s):

Xia HHX, Wong BCY

Department:

Medicine

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

01/2003

 

Abstract:

To investigate the expression of gastric-related homeobox genes in human normal, precancerous and cancerous gastric tissues in vivo, and in non-malignant and malignant gastric cancer cell lines in vitro; to determine the effect of gastric-related homeobox genes on the secretion of gastric endocrine hormones.

 

Project Title:

Molecular and genetic mechanisms of helicobacter pylori-induced antralization in gastric carcinogenesis

Investigator(s):

Xia HHX, Wong BCY

Department:

Medicine

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

12/2003

Completion Date:

12/2005

 

Abstract:

To explore the molecular and genetic mechanisms of H. pylori-induced antralization in gastric carcinogenesis; to identify the initial physiological changes in the process of H. pylori-induced antralization (the presence of antral-type mucosa) and precancerous lesions at the gastric incisura; to determine whether these physiological changes can be used as biomarkers for H. pylori-induced antralization and precancerous lesions at the gastric incisura; to determine whether the process of H. pylori-induced antralization and precancerous lesions at the gastric incisura involves a mutation or other genetic changes in homeobox genes.

 

Project Title:

Molecular and genetic mechanisms of helicobacter pylori-induced antralization in gastric carcinogenesis

Investigator(s):

Xia HHX, Wong BCY

Department:

Medicine

Source(s) of Funding:

Merit Award for RGC CERG Funded Projects

Start Date:

12/2003

 

Abstract:

N/A

 

Project Title:

Role of cyclooxygenase in helicobacter pylori-induced gastric carcinogenesis

Investigator(s):

Xia HHX, Wong BCY

Department:

Medicine

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

02/2004

 

Abstract:

To reveal the precise mechanism of COX and interrelationship between COX and H. pylori infection in the pathogenesis of gastric cancer; to provide insights into whether specific targets can be dealth with by new drugs, or a combination of drugs on different cellular targets to potentiate the chemoprevention effects; to develop effective strategies in the prevention of gastric cancer, for which no active agent or drug is available at present.

 

Project Title:

Role of macrophage migration inhibitory factor in Helicobacter pylori-induced gastric carcinogenesis

Investigator(s):

Xia HHX, Wong BCY

Department:

Medicine

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

05/2005

 

Abstract:

To determine the effect of MIF deficiency on H. pylori-induced inflammation and expression of inflammatory cytokines, cell proliferation and apoptosis and expression of related genes; to determine the difference in the incidence of gastric precancerous and cancerous lesions between MIF-knockout mice and wild-type mice after long-term infection with H. pylori.

 

Project Title:

Role of macrophage migration inhibitory factor in Helicobacter pylori-induced gastric carcinogenesis and effects of non-steroidal anti-inflammatory drugs

Investigator(s):

Xia HHX

Department:

Medicine

Source(s) of Funding:

Incentive Award for RGC CERG Fundable But Not Funded Projects

Start Date:

07/2005

Completion Date:

06/2006

 

Abstract:

N/A

 

Project Title:

Expression and role of homeobox gene PDX1 in gastric carcinogenesis

Investigator(s):

Xia HHX, Wong BCY

Department:

Medicine

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

04/2006

 

Abstract:

Homeobox genes encoding homeodomain transcription factors are involved in establishing gradients of differentiation during development of embryo and in maintaining these patterns in adult tissue [1,2]. Dysregulation of homeobox gene expression in cancer conforms to a simple rule: homeobox genes that are upregulated in cancer are normally expressed during development and/or in undifferentiated cells, whereas homeobox genes that are downregulated in cancer are normally expressed in adulthood and/or in differentiated tissues [3]. For example, two genes, CDX1 and CDX2, are normally expressed only in the intestine, and downregulation of CDX1 and CDX2 expression is associated with colorectal cancer. Pancreatic duodenal homeobox-1 protein (PDX-1), also known as IPF-1, STF1, or IDX-1 is one transcription factor in the ParaHox gene family. Generally, PDX1 gene is found normally in endocrine glands such as pancreatic beta-cells, Brunner's glands of the duodenum, and pyloric glands of the stomach [4,5]. PDX1 was confirmed to be a key regulator of pancreatic islet development and insulin gene transcription in beta-cells [6]. Recently, the association between PDX1 and gastric development is paid attention. Similar to expression of CDX2, PDX1 which is found in gastric endocrine glands, may be aberrantly expressed in hyperplasia, pancreatic or/and intestinal metaplasia and even gastric cancer. However, few recent studies involving PDX1 and gastric precancerous and cancer lesions produced different results. Whereas our previous study showed that, gastric expression of PDX1 was down-regulated in H pylori infected gastric mucosa and intestinal metaplasia with compared to normal mucosa [7], another recent study reported that PDX1 was frequently expressed in pseudopyloric glands and intestinal metaplasia [8]. Moreover, the exact regulatory function of PDX1 gene in gastric carcinogenesis is unknown. Purpose: 1. To investigate the expression of PDX1 gene in human normal, precancerous and cancerous gastric tissues in vivo; 2. To investifgate the expression of PDX1 gene in non-malignant and malignant gastric cancer cell lines in vitro. 3. To determine the effect of PDX1 gene on the secretion of gastric endocrine cells since PDX1 has been implicated in the regulation of G (gastrin-producing), D (somatostatin-producing) and EC (serotonin producing) cells in gastric antral mucosa [9]. Key issues and problems addressed 1. Whether PDX1 expression is dysregulaetd in gastric carcinogenesis; 2. Whether PDX1 plays an role in gastric carcinogenesis. Reference 1.Byrd JC, Yan P, Sternberg L, Yunker CK, Scheiman JM, Bresalier RS. Gastroenterology 1997;113:455-64. 2.Pitera JE, Smith VV, Thorogood P, Milla PJ. Gastroenterology 1999;117:1339-51. 3.Cory Abate-Shen. Nature Reviews/Cancer.2002;2:777-785. 4.Stoffers DA, Heller RS, Miller CP, et al. Endocrinology 1999;140:5374-81. 5.Larsson LI, Madsen OD, Serup P, et al. Mech Dev 1996;60:175-84. 6. Wang XP, Li Zh.J, Magnusson J, Brunicardi FC. World J. Surg. 2005;29:334-338. 7. Zhu S, Xia HHX., Lam SK, et al. Gastroenterology 2005, 128(4 Suppl 2): A598. 8. Sakai H, Eishi Y, Li XL, et al. Gut 2004;53:323-330. 9. Larsson LI, Madsen OD, Seraph P, Jonsson J, Edlundc H. Mech evelopment.1996;60:175-184.

 

List of Research Outputs

 

Chan O.O., Chu K.M., Leung S.Y., Huang C., Sun Y.W., Ko S., Yuen R.M.F., Xia H.H.X., Cho C.H., Hui W.M., Lam S.K., Rashid A. and Wong B.C.Y., Helicobacter pylori infection, interleukin 1 beta polymorphism and predisposition to gastric cancer through the CpG island methylation pathway, Presented at 11th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong, 14 January 2006.

 

Chan O.O., Chu K.M., Leung S.Y., Huang C., Sun Y., Ko S., Yuen R.M.F., Xia H.H.X., Cho C.H., Hui W.M., Lam S.K., Rashid A. and Wong B.C.Y., Helicobacter pylori Infection, Interleukin 1 Beta Polymorphism and Predisposition to Gastric Cancer Through the Cpg Island Methylation, Gastroenterology. 2006, 130 (4 Suppl 2): A-717.

 

Fan X.M., Jiang X., Gu Q., Ching Y.P., He H., Xia H.H.X., Lin M.C., Chan O.O., Yuen R.M.F., Kung H.F. and Wong B.C.Y., Inhibition of Akt/PKB by a COX-2 Inhibitor Induces Apoptosis in Gastric Cancer Cells, Digestion. 2006, 73(2-3): 75-83.

 

Gu Q., Xia H.H.X., Wang J., Wong R.W.M., Chan O.O., Lai K.C., Chan C.K., Yuen R.M.F., Fung F.M.Y., Wong K.W., Lam S.K. and Wong B.C.Y., Update on clarithromycin resistance in Helicobacter pylori in Hong Kong and its effect on clarithromycin-based triple therapy., Digestion. 2006, 72(2-3): 101-106.

 

Gu Q., Xia H.H.X., Wang J., Chan O.O., Lai K.C., Fung F.M.Y., Wong K.W., Cheung K.L., Kung H. and Wong B.C.Y., Update on clarithromycin resistance in Helicobacter pylori in Hong Kong and its effect on clarithromycin-based triple therapy., In: Gu Q, Xia HHX, Wang JD, Chan AOO, Lai KC, Chan CK, Yuen MF, Fung FMY, Wong KW, Cheung HKL, H.F. Kung HF, B.C.Y. Wong BCY.. , J Gastroenterol Hepatol . 2005, 20 (Suppl.): A160.

 

He H., Xia H.H.X., Wang J., Gu Q., Lin M.C., Zou B., Lam S.K., Chan O.O., Yuen R.M.F., Kung H.F. and Wong B.C.Y., Inhibition of human telomerase reverse transcriptase by nonsteroidal antiinflammatory drugs in colon carcinoma, Cancer. 2006, 106(6): 1243-9.

 

Jiang Y., Xia B., Jiang L., Lv M., Guo Q., Chen M., Li J., Xia H.H.X. and Wong B.C.Y., Association of CTLA-4 gene microsatellite polymorphism with ulcerative colitis in Chinese patients., Inflammatory bowel disease. 2006, 12(5): 369-373.

 

Li G., Xia H.H.X., Chen M., Gu Q., Wang J., Peng J., Chan O.O., Cho C.H., So H.L., Lam S.K., Hu P.J., Liang Y.J., Lin H., Berg D.E., Feng Z.H., Langenback R. and Wong B.C.Y., Effects of Cyclooxygenase-1 and -2 Gene Disruption on Helicobacter pylori-Induced Inflammation, Journal of Infectious Diseases. 2006, 193(7): 1037-1046.

 

Sun Y., Wang J., Xia H.H.X., Zou B., Lin M.C., Kung H. and Wong B.C.Y., Interferon-β-induced expression of XAF1 requires phosphorylation of STAT1 and a sequential activation of protein kinase C and JNK in colon cancer. Digestive Disease Week 2006, 20-25 May, Los Angeles, USA , Gastroenterology. 2006, 4 Suppl 2: A671.

 

Sun Y., Xia H.H.X., Zhu S., Zou B., Lin M.C., Kung H. and Wong B.C.Y., Novel interaction between xiap-associated factor 1 (XAF1) and nuclear coactivator CBP in colon cancer. Digestive Disease Week 2006, 20-25 May, Los Angeles, USA , Gastroenterology. 2006, 4 Suppl 2: A680.

 

Tang L.P., Cho C.H., Hui W.M., Huang F.Y., Lai C.L., Xia H.H.X., Lam S.K., Rashid A., Wong B.C.Y. and Chan O.O., A negative correlation between IL-6 and DNA methylation in patients with gastric cancer, Supplement to Gastroenterology - Digestive Disease Week and the 107th Annual Meeting of the American Gastroenterological Association Institute, May 20-25, 2006, Los Angeles, CA. 2006, 130:4 Suppl 2: A-717.

 

Wang J., Peng Y., Sun Y., He H., Zhu S., An X.M., Li M., Lin M.C., Zou B., Xia H.H.X., Jiang B., Chan O.O., Yuen R.M.F., Kung H.F. and Wong B.C.Y., All-Trans Retinoic Acid Induces XAF1 Expression Through an Interferon Regulatory Factor-1 Element in Colon Cancer, Gastroenterology. 2006, 130(3): 747-758.

 

Wang J., He H., Yu L., Xia H.H.X., Lin M.C., Gu Q., Li M., Zou B., An X.M., Jiang B., Kung H.F. and Wong B.C.Y., HSF1 down-regulates XAF1 through transcriptional regulation, Journal of Biological Chemistry. 2006, 281(5): 2451-2459.

 

Wang W., Huang J., Zheng G., Xia H.H.X., Wong R.W.M., Lam S.K. and Wong B.C.Y., Head-to-Head Comparison of H2-Receptor Antagonists and Proton Pump Inhibitors in the Treatment of Erosive Esophagitis: A Meta-Analysis, World Journal of Gastroenterology. 2005, 11(26): 4067-4077.

 

Xia B., Xia H.H.X., Ma C.W., Wong K.W., Fung F.M.Y., Hui C.K., Chan C.K., Chan O.O., Lai K.C., Yuen R.M.F. and Wong B.C.Y., Trends in the prevalence of peptic ulcer disease and Helicobacter pylori infection in family physician-referred uninvestigated dyspeptic patients in Hong Kong. , Alimentary Pharmacology and Therapeutics. 2005, 22(3): 243-9.

 

Xia H.H.X., Editorial Board, Alimentary Pharmacology & Therapeutics,. 2006.

 

Xia H.H.X., He H., Wang J., Gu Q., Lin M.C., Zou B., Yu L., Sun Y., Chan O.O., Kung H.F. and Wong B.C.Y., Induction of apoptosis and cell cycle arrest by a specific c-Jun NH(2)-terminal kinase (JNK) inhibitor, SP-600125, in gastrointestinal cancers., Cancer Letters. 2005, 241(2): 268-74.

 

Xia H.H.X., Molecular mechanisms of Helicobacter pylori induced gastric cancer., The 12th Hong Kong International Cancer Congress & the 2nd Annual Meeting of Centre for Cancer Research, Hong Kong, 8-10 December 2005.. 2005.

 

Xia H.H.X., Wong R.W.M., Chan O.O., Lam S.K., Lai K.C., Chan C.K., Cheung K.L., Fung F.M.Y., Wong K.W. and Wong B.C.Y., Natural acquisition of Helicobacter pylori in adult dyspeptic patients with or without previous infection – a 7-year follow-up study. Australian Gastroenterology Week 2005, 19 October 2005, Australia. , Journal of Gastroenterology and Hepatology. 2005, 20: Supp A112.

 

Researcher : Xu A



Project Title:

Hepatocytes as a major therapeutic target for the anti-diabetic and anti-inflammatory hormone adiponectin

Investigator(s):

Xu A, Lam KSL

Department:

Medicine

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

02/2004

Completion Date:

05/2006

 

Abstract:

To define the roles of two recently identified adiponectin receptors and several intracellular signaling pathways (AMP-activated protein kinase, P38 MAP kinase and PPAR[alpha]) in mediating the multiple biological actions of adiponectin in hepatocytes; to investigate how phosphorylation modulates the activities of adiponectin receptors; to identify the membrane-proximal downstream signaling molecules of adiponectin receptors in hepatocytes.

 

Project Title:

An adipokine- and cytokine-based antibody biochips for early diagnosis, risk detection and therapeutic monitoring of cardiovascular diseases and diabetes

Investigator(s):

Xu A, Lam KSL, Zhang W.W.

Department:

Medicine

Source(s) of Funding:

Seed Funding Programme for Applied Research

Start Date:

09/2004

Completion Date:

09/2005

 

Abstract:

To generate an antibody chips that can simultaneously detect multiple adipolines, cytolines and acute phase proteins in qualitative and quantitative ways.

 

Project Title:

Characterization of the receptor and postreceptor events that underlie the anti-atherogenic and anti-diabetic actions of adiponectin

Investigator(s):

Xu A

Department:

Medicine

Source(s) of Funding:

Merit Award for RGC CERG Funded Projects

Start Date:

01/2005

 

Abstract:

N/A

 

Project Title:

Characterization of the receptor and postreceptor events that underlie the anti-atherogenic and anti-diabetic actions of adiponectin

Investigator(s):

Xu A, Lam KSL

Department:

Medicine

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

01/2005

 

Abstract:

The proposal seeks to address the following three questions: (1) how does adiponectin activate its receptors? (2) what are the membrane proximal down-stream signaling events of adiponectin receptors? how does adiponectin exert its anti-atherogenic actions via macrophage cells?

 

Project Title:

Structural and functional characterization of angiopoietin-like protein 4 (ANGPTL4), a novel hormone involved in glucose homeostasis and insulin sensitivity

Investigator(s):

Xu A, Lam KSL

Department:

Medicine

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

03/2005

Completion Date:

03/2006

 

Abstract:

To elucidate the molecular and structural basis that underlies the glucose-lowering and insulin-sensitising functions of ANGPTL4.

 

Project Title:

Angiopoitein-like protein 4 (ANGPTL4) as a novel therapeutic target for the treatment of insulin resistance and hyperglycemia

Investigator(s):

Xu A

Department:

Medicine

Source(s) of Funding:

Merit Award for RGC CERG Funded Projects

Start Date:

12/2005

 

Abstract:

N/A

 

Project Title:

Angiopoitein-like protein 4 (ANGPTL4) as a novel therapeutic target for the treatment of insulin resistance and hyperglycemia

Investigator(s):

Xu A, Lam KSL

Department:

Medicine

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

12/2005

 

Abstract:

To investigate the direct metabolic effects of angiopoietin-like protein 4 on liver and muscle, the two major organs involved in the regulation of systemic energy metabolism and insulin sensitivity; to elucidate the detailed metabolic pathways and signal transduction events that mediate the hypoglycemia and insulin-sensitizing effects of angiopoietin-like protein 4..; to study whether oligomerization and/or proteolysis plays a role in modulating the biological activities of angiopoietin-like protein 4.

 

Project Title:

The use of adiponectin as a biomarker to identify novel anti-diabetic and anti-atherogenic agents from Chinese herbs

Investigator(s):

Xu A, Qin GW, Lam KSL, Wang HB

Department:

Medicine

Source(s) of Funding:

NSFC/RGC Joint Research Scheme

Start Date:

01/2006

 

Abstract:

To determine and optimize the chemical structures for the three bioactive compounds isolated from Rhizoma Dioscoreae and Radix Astragali; to study the molecular mechanisms by which the three bioactive compounds induce adiponectin production from fat cells; to explore the therapeutic potentials of the three bioactive compounds in the treatment of T2DM, endothelial dysfunction, atherosclerosis and other obesity-related metabolic disorders in several well-established animal models.

 

Project Title:

Inflammation in adipose tissue as a novel mechanism that link obesity with insulin reistance and type 2 diabetes

Investigator(s):

Xu A, Lam KSL, Chung SK

Department:

Medicine

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

03/2006

 

Abstract:

Obesity and its associated pathologies, including Type 2 Diabetes Mellitus (T2DM) and atherosclerosis, are chronic inflammatory diseases, characterized by elevated plasma concentrations of pro-inflammatory biomarkers, such as C-reactive proteins, TNF alpha and interleulin (IL) 6 (Bouloumie, Curat et al. 2005). Recent studies have found that adipose tissue (fat) is the predominant site that contributes to obesity-associated systemic inflammation and metabolic disorders (Wellen and Hotamisligil 2005). Macrophage infiltration and up-regulation of the inflammation-related genes in obese adipose tissue occur at the early phase of obesity and precede the development of insulin resistance (Xu, Barnes et al. 2003). It is suggested that activated macrophages in obese adipose tissue, in concert with the enlarged adipocytes, secrete a variety of pro-inflammatory adipokines/cytokines, which either act locally to perpetuate adipose tissue inflammation, or are released into the blood stream to induce systemic inflammation, insulin resistance and metabolic disorders in the periphery organs. Nevertheless, the mechanism responsible for triggering and perpetuating macrophage infiltration into obese adipose tissue remains poorly understood. It is also unclear whether inhibition of local inflammation in adipose tissue is sufficient to alleviate obesity-induced systemic inflammation and insulin resistance. Hypoxia inducible factor (HIF) 1alpha, a major transcription factor involved in the cellular response to hypoxia, has recently neen shown to be an important player in the inflammatory process (Paul, Simons et al. 2004). Studies in both human subjects and rodents have found that the expressions of HIF 1alpha in obese adipose tissue are substantially elevated (Trayhurn and Wood 2004; Cancello, Henegar et al. 2005). Weight loss, on the other hand, results in decreased expression of this transcription factor as well as reduced adipose tissue inflammation. Our in vitro studies showed that hypoxia, via induction of HIF 1alpha, could inhibit the production of the anti-inflammatory hormone adiponectin, but increase the expression of a cluster of pro-angiogenic and pro-inflammatory mediators from adipocytes, including leptin, VEGF, PAI-1 and IL6 (Chen, Wang et al.). In addition, we also demonstrated that HIF 1alpha activation could significantly enhance adipocyte-mediated adhesion and transmigration of human blood monocytes to/through the endothelial cells, the key step involved in macrophage tissue infiltration. Based on these evidences, we propose that HIF 1alpha plays a key role in initiating and/or maintaining chronic inflammation of adipose tissue and in triggering aberrant production of adipokines in obesity. As obesity develops, enlarged fat mass causes local micro-hypoxia and oxidative stress, both of which can induce HIF 1alpha accumulation and activation. Activated HIF 1alpha can decrease production of adiponectin and increase expression of macrophage attractants (such as leptin, VEGF, PAI-1, IL6, proteases and other chemokines). These changes can stimulate transport of monocytes to adipose tissue and promote adhesion and transmigration of monocytes to/through endothelial cells. Infiltrated monocytes in adipose tissue can be differentiated into macrophages by other locally produced inflammatory mediators. Activated macrophages in turn secrete a cluster of pro-inflammatory cytokines (such as IL1, TNFalpha and MCP1), which can act in a paracrine manner to induce further accumulation of HIF 1alpha in adipocytes, macrophage infiltration and aberrant production of adipokines. The macrophage-adipocyte interaction will perpetuate a viscous cycle that aggravates inflammatory responses in adipose tissue, and eventually induces systemic inflammation and insulin resistance. To test this hypothesis, the major objectives of this study are: 1. To generate the transgenic mice with adipose tissue specific over-expression of dominant negative or constitutively active forms of HIF 1alpha; 2. To investigate the role of HIF 1alpha in obesity-induced macrophage infiltration and aberrant production of adipokines in adipose tissue, systemic inflammation and insulin resistance in the transgenic mouse models; 3. To elucidate the molecular mechanisms by which HIF 1alpha induces endothelial cell activation and monocyte recruitment in adipose tissue; 4. To evaluate whether berberine, a compound with potent HIF 1alpha inhibitor activity, has therapeutic effects on obesity-associated chronic inflammation, insulin resistance and other metabolic abnormalities in mice.

 

List of Research Outputs

 

Chen B., Lam K.S.L., Wang Y., Wu D., Lam C.W., Shen J., Wong L.C., Hoo R.L.C., Zhang J. and Xu A., Hypoxia dysregulates the production of adiponectin and plasminogen activator inhibitor-1 independent of reactive oxygen species in adipocytes, Biochem Biophys Res Commun. 2006, 341: 549-56.

 

Cheng K.Y., Lam K.S.L. and Xu A., Receptor and postreceptor signalling pathways that mediate adiponectin-induced Akt activation in endothelial cells, 11th Medical Research Conference, HKU, Jan 2006.

 

Fang X., Pananivel R., Zhou X., Liu Y., Xu A., Wang Y. and Sweeney G., Hyperglycemia- And Hyperinsulinemia-induced Alteration Of Adiponectin Receptor Expression And Adiponectin Effects In L6 Myoblasts. , J Mol Endocrinol. Society for Endocrinology, 2005, 35: 465-76.

 

Lam K.S.L. and Xu A., Adiponectin: Protection Of The Endothelium. , Curr Diab Rep. 2005, 4: 254-9.

 

Man K., Zhao Y., Xu A., Lo C.M., Lam K.S.L., Ng T.P., Ho J.W.Y., Sun K.W., Lee K.W., Li X. and Fan S.T., Fat-derived hormone adiponectin combined with FTY720 significantly improves small-for-size fatty liver graft survival, American Journal of Transplantation. 2006, 6(3): 467-476.

 

Tso A.W.K., Wat N.M.S., Xu A., Tam S., Fong H.Y., Janus E.D., Tan K.C.B. and Lam K.S.L., Adiponectin/C-reactive protein ratio is an independent surrogate marker predictive of the development of metabolic risks and the metabolic syndrome over 5 years in Chinese, The 6th International Diabetes Federation Western Pacific Region Congress, Bangkok, Oct 2005.

 

Wang Y., Lam K.S.L., Leung T.Y. and Xu A., Overexpression of Angiopoietin-like Protein 4 Alters the Protein Expression Profiles of the Liver Tissue in DB/DB Diabetic Mice, Molecular & Cellular Proteomics. HUPO 4th Annual Congress, 2005, 4 (S1): S200.

 

Wang Y., Lam K.S.L., Lam M. and Xu A., Overexpression of Angiopoietin-like protein 4 alters the protein expression profiles of the liver tissue in db/db diabetic mice, HUPO 4th Annual World Congress. 2005, 4: S200.

 

Wang Y., Lam K.S.L., Chan L., Chan K.W., Lam J.B.B., Lam C.W., Hoo R.L.C., Mak W.W., Cooper G.J. and Xu A., Post-translational modifications of the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high molecular weight oligomeric complex, J Biol Chem. 2006, 281: 16391-400.

 

Wang Y., Lam K.S.L., Chan L., Chan K.W., Lam J.B.B., Lam C.W., Hoo R.L.C., Mak W.W., Cooper G.J.S. and Xu A., Posttranslational modifications on the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high-molecular-weight oligomeric complex, J Biol Chem. 2006.

 

Wang Y., Lam K.S.L., Cooper G.J. and Xu A., Structural and functional relationship of Adiponectin as an anti-aging hormone, Frontiers in Biomedical Research. 2005, 62.

 

Xu A., Wang Y., Xu J., Stejskal D., Tam S., Zhang J., Wat N.M.S., Wong W.K. and Lam K.S.L., Adipocyte fatty acid-binding protein is a plasma biomarker closely associated with obesity and metabolic syndrome, Clinical Chemistry. 2006, 52: 405-413.

 

Researcher : Xu J



Project Title:

Search for susceptibility gene loci for maturity-onset diabetes of the young in Southern Chinese

Investigator(s):

Xu J, Lam KSL, Sham PC

Department:

Medicine

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

 

Abstract:

To further study the extended MODYX families recruited from our previous project and screen for MODY loci in Southern Chinese, starting with MODY loci reported in other populations; to investigate whether there is overlap between MODY loci and reported T2DM loci in Chinese, based on studies with predilection of early onset T2DM diagnosed before 40 years of age.

 

List of Research Outputs

 

Xu A., Wang Y., Xu J., Stejskal D., Tam S., Zhang J., Wat N.M.S., Wong W.K. and Lam K.S.L., Adipocyte fatty acid-binding protein is a plasma biomarker closely associated with obesity and metabolic syndrome, Clinical Chemistry. 2006, 52: 405-413.

 

Researcher : Xue T



List of Research Outputs

 

Tse H.F., Xue T., Lau C.P., Siu C.W.D., Wang K., Zhang Q.Y., Tomaselli G.F., Akar F.G. and Li R.A., Bioartifical sinus node constructed via in vivo gene transfer of an engineered pacemaker HCN channel reduces the dependence on electronic pacemaker in a sick sinus syndrome model, Circulation. 2006, 114: 1000-1011.

 

Researcher : Yam LYC



List of Research Outputs

 

Hou H.M., Sam K., Hagg E.U.O., Rabie A.B.M., Bendeus S.A.M., Yam L.Y.C. and Ip M.S.M., Long-term dento-facial changes in Chinese OSA patients following treatment with a mandibular advancement device, The Angle Orthodontist. 2006, 76: 432-440.

 

Researcher : Yan CPK



List of Research Outputs

 

Ho P.L., Chau P.H., Yip P.S.F., Ooi C.G.C., Khong P.L., Ho J.C.M., Wong P.C., Ko C.F., Yan C.P.K. and Tsang K.W.T., A prediction rule for clinical diagnosis of severe acute respiratory syndrome, European Respiratory Journal. 2005, 26(3): 474-9.

 

Kwok R.P., Sun J.Z., Tipoe G.L., Leung Y.H., Yan C.P.K., Ooi C.G.C., Ho P.L., Mak J.C.W., Lam W.K. and Tsang K.W.T., Pseudomonas aeruginosa pyocyanin : discruption of ultrastructure of human respiratory mucosa in vitro, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong,. 2006, Abstract Book 087: pp. 55.

 

Kwok R.P., Sun J.Z., Tipoe G.L., Leung Y.H., Yan C.P.K., Ooi C.G.C., Ho P.L., Mak J.C.W., Lam W.K. and Tsang K.W.T., Pseudomonas aeruginosa pyocyanin : discruption of ultrastructure of human respiratory mucosa in vitro, Respirology. 2005, 10 (Suppl): A126 (#170).

 

Kwok R.P., Leung Y.H., Sun J.Z., Yan C.P.K., Ooi C.G.C., Ho P.L., Tipoe G.L., Lam W.K. and Tsang K.W.T., The effects of gelomyrtol ForteÒ on human ciliary beat frequency in bronchiectasis subjects in vitro, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2006, Abstract Book 086: pp.54.

 

Kwok R.P., Leung Y.H., Sun J.Z., Yan C.P.K., Ooi C.G.C., Ho P.L., Tipoe G.L., Lam W.K. and Tsang K.W.T., The effects of gelomyrtol forteÒ on human ciliary beat frequency in bronchiectasis subjects in vitro, Respirology. 2005, 10 (Suppl): A126 (#169).

 

Kwok R.P., Leung Y.H., Sun J.Z., Yan C.P.K., Ko K.W., Ooi C.G.C., Ho P.L., Tipoe G.L., Lam W.K. and Tsang K.W.T., The effects of myrtol standardized on human ciliary beat frequency in vitro, European Respiratory Medicine. 2005, 26 (Suppl 49): 100S (#714).

 

Mak J.C.W., Ho S.P., Leung Y.H., Ho P.L., Ooi C.G.C., Tipoe G.L., Yan C.P.K., Ip M.S.M., Lam W.K. and Tsang K.W.T., Elevated levels of transforming growth factor-beta(1) in serum of patients with stable bronchiectasis, Respiratory Medicine. 2005, 99: 1223-1228.

 

Researcher : Yang Y



List of Research Outputs

 

Zou B., Lin M.C., Lam S.K., Tu S., Zeng H., Yang Y., Wang J., He H., Jiang S.H., Kung H. and Wong B.C.Y., Distinguished Poster Award, "Hypermethylation status around exon 1 of XIAP-Associated Factor 1(XAF1) in human gastric and colon cancer cell line.", Asian Pacific Digestive Week, Sept. 25-28, Seoul, Korea.. 2005.

 

Zou B., Lin M.C., Lam S.K., Tu S., Zeng H., Yang Y., Wang J., He H., Jiang S.H., Kung H. and Wong B.C.Y., Hypermethylation status around exon 1 of XIAP-Associated Factor 1(XAF1) in human gastric and colon cancer cell line. Asian Pacific Digestive Week, Sept. 25-28, 2005, Seoul, Korea. , Journal of Gastroenterology and Hepatology. 2005, 20: Supp A370.

 

Researcher : Yee YK



List of Research Outputs

 

Wong W.M.R., Gu Q., Chu K.M., Yee Y.K., Fung F.M.Y., Tong S.M., Chan O.O.A., Lai K.C., Chan C.K. and Wong B.C.Y., Lansoprazole, levofloxacin and amoxicillin triple therapy versus quadruple therapy as second-line treatment of resistant Helicobacter pylori infection, Alimentary Pharmacology & Therapeutics. 2006, 23: 421-427.

 

Researcher : Yeung CK



List of Research Outputs

 

Hung I.F.N., Wu A.K.L., Cheng V.C.C., Tang S.F., To K.K.W., Yeung C.K., Woo P.C.Y., Lau S.K.P., Cheung B.M.Y. and Yuen K.Y., Fatal interaction between clarithromycin and colchicine in patients with renal insufficiency: a retrospective study., Clinical infectious diseases. 2005, 41(3): 291-300.

 

Kwong Y.L., Lau W.C.S., Ho S.L., Epstein R., Young R.T.T., Chan H.H.L., Tse H.F., Lam L., Chen W.H., Lee K.L.F., Ip M.S.M., Tsang K.W.T., Lam B., Tang S.C.W., Chan R.H.W., Lee S.W.L., Tan K.C.B., Yeung C.K., Chan D.T.M., Wong R.W.S., Choy C.B.Y., Wong B.C.Y., Li F.K., Lo W.K., Lui S.L., Cheung R.T.F., Mak W., Ho J.C.M., Mok T.M.Y., Kung A.W.C., Cheung B.M.Y., Chow W.S., Yuen R.M.F. and Wat N.M.S., In: Lau CP, Kumana CR, Lai CL, Lai KN, Lam KSL, Lam WK, Problem-Based Medical Case Management. Hong Kong, Hong Kong University Press, 2005.

 

Researcher : Yew WW



List of Research Outputs

 

Chan M.M.W., Yeh A.G.O., Tam C.M., Kam K.M., Leung C.C., Yew W.W. and Lam C.W., Socio-demographic and geographic indicators and distribution of tuberculosis in Hong Kong: a spatial analysis. , International Journal of Tuberculosis and Lung Disease. 2005, 9(12): 1320-6.

 

Researcher : Yik PY



List of Research Outputs

 

Li Y., Leung W.C.W., Chen Y., Cheung B.M.Y., Liang R. Y.H., Yik P.Y., Hui K.C., Ng P.K.M., Mak W.W., Jin D. and Song Y., Association of the cholesterol 24S-hydroxylase polymorphism with Alzheimer's disease in Chinese, HUGO 2006 Helsinki, Finland, 31 May-03 June 2006 . 2006.

 

Li Y., Leung W.C.W., Chen Y., Cheung B.M.Y., Liang R.Y.H., Yik P.Y., Ng K.M., Mak W., Jin D., st. George-Hyslop P. and Song Y., Intron 2 (T/C) CYP46 polymorphism is associated with Alzheimer's disease in Chinese. , Dement Geriatr Cogn Disord. 2006, 22: 399-404.

 

Researcher : Young RTT



List of Research Outputs

 

Kwong Y.L., Lau W.C.S., Ho S.L., Epstein R., Young R.T.T., Chan H.H.L., Tse H.F., Lam L., Chen W.H., Lee K.L.F., Ip M.S.M., Tsang K.W.T., Lam B., Tang S.C.W., Chan R.H.W., Lee S.W.L., Tan K.C.B., Yeung C.K., Chan D.T.M., Wong R.W.S., Choy C.B.Y., Wong B.C.Y., Li F.K., Lo W.K., Lui S.L., Cheung R.T.F., Mak W., Ho J.C.M., Mok T.M.Y., Kung A.W.C., Cheung B.M.Y., Chow W.S., Yuen R.M.F. and Wat N.M.S., In: Lau CP, Kumana CR, Lai CL, Lai KN, Lam KSL, Lam WK, Problem-Based Medical Case Management. Hong Kong, Hong Kong University Press, 2005.

 

Researcher : Yu L



List of Research Outputs

 

Wang J., He H., Yu L., Xia H.H.X., Lin M.C., Gu Q., Li M., Zou B., An X.M., Jiang B., Kung H.F. and Wong B.C.Y., HSF1 down-regulates XAF1 through transcriptional regulation, Journal of Biological Chemistry. 2006, 281(5): 2451-2459.

 

Xia H.H.X., He H., Wang J., Gu Q., Lin M.C., Zou B., Yu L., Sun Y., Chan O.O., Kung H.F. and Wong B.C.Y., Induction of apoptosis and cell cycle arrest by a specific c-Jun NH(2)-terminal kinase (JNK) inhibitor, SP-600125, in gastrointestinal cancers., Cancer Letters. 2005, 241(2): 268-74.

 

Yu L., Wang J., Zou B., Lin M.C., Wu Y.L. and Wong B.C.Y., Sulindac Metabolites Induces XAF1 Expression by Inhibition of Extracellular Signal-regulated Kinase 1/2 Phosphorylation in Human Gastric Cancer Cells. Oral presentation, Asian Pacific Digestive Week 2005, Sept. 25-28, 2005, Seoul, Korea , Journal of Gastroenterology and Hepatology. 2005, 20: Supp A299.

 

Yu L., Wang J., Zou B., Wu Y.L. and Wong B.C.Y., XAF1 mediates inhibition of extracellular signal-regulated kinase 1/2 induced apoptosis in human colon cancer cells. Digestive Disease Week 2006, 20-25 May, Los Angeles, USA , Gastroenterology. 2006, 4 Suppl 2: A531.

 

Zou B., Chim J.C.S., Lin M.C., Zeng H., He H., Yu L., Sun Y., Jiang S.H. and Wong B.C.Y., Correlation between the single-site CpG mutation within the gene promoter and the expression silencing of XIAP -Associated Factor 1 (XAF1) in human colon cancer cell lines. Asian Pacific Digestive Week, Sept. 25-28, 2005, Seoul, Korea., Journal of Gastroenterology and Hepatology. 2005, 20: Supp A253.

 

Zou B., Chim J.C.S., Lin M.C., Zeng H., He H., Yu L., Sun Y., Jiang S.H. and Wong B.C.Y., Distinguished Poster Award, "Correlation between the single-site CpG mutation within the gene promoter and the expression silencing of XIAP -Associated Factor 1 (XAF1) in human colon cancer cell lines" , Asian Pacific Digestive Week, Sept. 25-28, Seoul, Korea. 2005.

 

Researcher : Yuan H



List of Research Outputs

 

Yuan H., Yuen R.M.F., Wong D.K.H., Sum S.M., Sablon E., Ng I.O.L. and Lai C.L., Impact of Precore and Core Promoter Mutations on Hepatic Histology in Patients with Chronic Hepatitis B, Alimentary Pharmacology and Therapeutics. 2005, 22: 301-307.

 

Yuen R.M.F., Tanaka Y., Ng I.O.L., Mizokami M., Yuen J.C.H., Wong D.K.H., Yuan H., Sum S.M., Chan O.O. and Lai C.L., Hepatic necroinflammation and fibrosis in patients with genotypes Ba and C, core-promoter and precore mutations, Journal of Viral Hepatitis . 2005, 12(5): 513-8.

 

Yuen R.M.F., Yuan H., Wong D.K.H., Yuen J.C.H., Wong R.W.M., Chan O.O., Wong B.C.Y., Lai K.C. and Lai C.L., Prognostic determinants for chronic hepatitis B in Asians: therapeutic implications. , Gut. 2005, 54(11): 1610-4.

 

Researcher : Yuen JCH



List of Research Outputs

 

Sum S.M., Wong D.K.H., Yuen J.C.H., Lai C.L. and Yuen R.M.F., Comparison of the COBAS TaqMan HBV Test with the COBAS Amplicor Monitor Test for Measurement of Hepatitis B Virus DNA in Serum, Journal of Medical Virology. 2005, 77: 486-490.

 

Yuen R.M.F., Tanaka Y., Ng I.O.L., Mizokami M., Yuen J.C.H., Wong D.K.H., Yuan H., Sum S.M., Chan O.O. and Lai C.L., Hepatic necroinflammation and fibrosis in patients with genotypes Ba and C, core-promoter and precore mutations, Journal of Viral Hepatitis . 2005, 12(5): 513-8.

 

Yuen R.M.F., Wong D.K.H., Chan C.C.S., Zheng B.J., Yuen J.C.H. and Lai C.L., Immune response during immunoclearance phase of Chinese patients with HBV genotypes B and C., Journal of hepatology : the journal of the European Association for the Study of the Liver. 2005, 42 (Suppl 2): 152.

 

Yuen R.M.F., Yuan H., Wong D.K.H., Yuen J.C.H., Wong R.W.M., Chan O.O., Wong B.C.Y., Lai K.C. and Lai C.L., Prognostic determinants for chronic hepatitis B in Asians: therapeutic implications. , Gut. 2005, 54(11): 1610-4.

 

Researcher : Yuen RMF



List of Research Outputs

 

Au W.Y., Lam C.C.K., Liu C.L. and Yuen R.M.F., Hepatitis C virus infection in adult Chinese hemophilia patients negative for the human immunodeficiency virus: treatment results with interferon and ribavirin, International Journal of Hematology. 2005, 82(3): 259-261.

 

Chan O.O., Hui W.M., Chan C.K., Lai K.C., Hu H.C., Yuen R.M.F., Wong R.W.M., Lau G., Hui C.K., Lam S.K. and Wong B.C.Y., Colonoscopy Demand and Practice in a Regional Hospital over 9 Years in Hong Kong: Resource Implication for Cancer Screening, Gastroenterology. 2006, 130 (4 Suppl 2): A-618.

 

Chan O.O., Hui W.M., Chan C.K., Lai K.C., Hu H.C., Yuen R.M.F., Wong R.W.M., Lau G., Hui C.K., Lam S.K. and Wong B.C.Y., Colonoscopy demand and practice in a regional hospital over 9 years in Hong Kong: Resource implication for cancer screening, Digestion. 2006, 73(2-3): 84-88.

 

Chan O.O., Chu K.M., Lam S.K., Cheung K.L., Law S.Y.K., Kwok K.F., Wong R.W.M., Yuen R.M.F. and Wong B.C.Y., Early prediction of tumor recurrence after curative resection of gastric carcinoma by measuring soluble E-cadherin, Cancer. 2005, 104(4): 740-6.

 

Chan O.O., Peng J., Lam S.K., Lai K.C., Yuen R.M.F., Cheung K.L., Kwong Y.L., Rashid A., Chan C.K. and Wong B.C.Y., Eradication of Helicobacter pylori Infection Reverses E-cadherin Promoter Hypermethylation, Gut. 2006, 55: 463-468.

 

Chan O.O., Hui W.M., Hu H.C., Leung G., Chan C.K., Yuen R.M.F., Lam S.K. and Wong B.C.Y., Familial Aggregation in Constipated Subjects in a Tertiary Referral Center, Gastroenterology. 2006, 130 (4 Suppl 2): A-159.

 

Chan O.O., Chu K.M., Leung S.Y., Huang C., Sun Y.W., Ko S., Yuen R.M.F., Xia H.H.X., Cho C.H., Hui W.M., Lam S.K., Rashid A. and Wong B.C.Y., Helicobacter pylori infection, interleukin 1 beta polymorphism and predisposition to gastric cancer through the CpG island methylation pathway, Presented at 11th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong, 14 January 2006.

 

Chan O.O., Jim M.H., Lam K.F., Siu D.C.W., Tong S.M., Ng F.H., Hui W.M., Chan C.K., Lai K.C., Hu H.C., Yuen R.M.F., Lau Y.K., Lee S.W.L., Lam S.K. and Wong B.C.Y., Patients with Coronary Artery Disease are at High Risk for Developing Colorectal Cancer and Adenoma: An Interim Analysis of a Prospective Study, Gastroenterology. 2006, 130 (4 Supp 2): A-36.

 

Chan O.O., Hui W.M., Lam K.F., Leung G., Hu H.C., Chan C.K., Yuen R.M.F., Lam S.K. and Wong B.C.Y., The Clinical Characteristics of Patients with Idiopathic Constipation with a Positive Family History, Gastroenterology. 2006, 130 (4 Suppl 2): A-158.

 

Chan O.O., Chu K.M., Sun Y.W., Cheung H.K.L., Lam S.K., Yuen R.M.F., Hui W.M. and Wong B.C.Y., The association between interleukin 1 beta polymorphism and hypermethylation at tumor suppressor genes in gastric cancer. , Gastroenterology. 2005, 128 (Suppl 2): 1399-400.

 

Chan O.O., Lam K.F., Hui W.M., Hu W.H., Li J., Lai K.C., Chan C.K., Yuen R.M.F., Lam S.K. and Wong B.C.Y., Validated questionnaire on diagnosis and symptom severity for functional constipation in the Chinese population, Alimentary Pharmacology and Therapeutics. Blackwell Publishing Ltd, 2005, 22: 483-488.

 

Chan O.O., Chu K.M., Leung S.Y., Huang C., Sun Y., Ko S., Yuen R.M.F., Xia H.H.X., Cho C.H., Hui W.M., Lam S.K., Rashid A. and Wong B.C.Y., Helicobacter pylori Infection, Interleukin 1 Beta Polymorphism and Predisposition to Gastric Cancer Through the Cpg Island Methylation, Gastroenterology. 2006, 130 (4 Suppl 2): A-717.

 

Chong W.P., To Y.F., Ip W.K.E., Yuen R.M.F., Poon R.T.P., Wong W.H.S., Lai C.L. and Lau Y.L., Mannose-binding lectin in chronic hepatitis B virus infection, Hepatology. 2005, 42(5): 1037-1045.

 

Fan X.M., Jiang X., Gu Q., Ching Y.P., He H., Xia H.H.X., Lin M.C., Chan O.O., Yuen R.M.F., Kung H.F. and Wong B.C.Y., Inhibition of Akt/PKB by a COX-2 Inhibitor Induces Apoptosis in Gastric Cancer Cells, Digestion. 2006, 73(2-3): 75-83.

 

Gu Q., Xia H.H.X., Wang J., Wong R.W.M., Chan O.O., Lai K.C., Chan C.K., Yuen R.M.F., Fung F.M.Y., Wong K.W., Lam S.K. and Wong B.C.Y., Update on clarithromycin resistance in Helicobacter pylori in Hong Kong and its effect on clarithromycin-based triple therapy., Digestion. 2006, 72(2-3): 101-106.

 

He H., Xia H.H.X., Wang J., Gu Q., Lin M.C., Zou B., Lam S.K., Chan O.O., Yuen R.M.F., Kung H.F. and Wong B.C.Y., Inhibition of human telomerase reverse transcriptase by nonsteroidal antiinflammatory drugs in colon carcinoma, Cancer. 2006, 106(6): 1243-9.

 

Ito K., Tanaka Y., Orito E., Sugiyama M., Fujiwara K., Sugauchi F., Kato T., Tokita H., Izumi N., Kato M., Yuen R.M.F., Lai C.L., Gish R.G., Ueda R. and Mizokami M., T1653 Mutation in the Box Alpha Increases the Risk of Hepatocellular Carcinoma in Patients with Chronic Hepatitis B Virus Genotype C Infection, Clinical Infectious Disease. 2006, 42: 1-7.

 

Ito K., Tanaka Y., Sugiyama M., Fujiwara K., Sugauchi F., Orito E., Asahina Y., Tokita H., Yuen R.M.F., Lai C.L., Acharya S.A., Gish R. and Mizokami M., T1653 mutation in the box alpha increases the risk of hepatocellular carcinoma in patients with chronic hepatitis B virus infection, Hepatology. 2005, 42 (Suppl 1): 720A.

 

Kwong Y.L., Lau W.C.S., Ho S.L., Epstein R., Young R.T.T., Chan H.H.L., Tse H.F., Lam L., Chen W.H., Lee K.L.F., Ip M.S.M., Tsang K.W.T., Lam B., Tang S.C.W., Chan R.H.W., Lee S.W.L., Tan K.C.B., Yeung C.K., Chan D.T.M., Wong R.W.S., Choy C.B.Y., Wong B.C.Y., Li F.K., Lo W.K., Lui S.L., Cheung R.T.F., Mak W., Ho J.C.M., Mok T.M.Y., Kung A.W.C., Cheung B.M.Y., Chow W.S., Yuen R.M.F. and Wat N.M.S., In: Lau CP, Kumana CR, Lai CL, Lai KN, Lam KSL, Lam WK, Problem-Based Medical Case Management. Hong Kong, Hong Kong University Press, 2005.

 

Lai C.L., Chen S., Wong B.C.Y. and Yuen R.M.F., Gastroenterology and Hepatology., In: Lau CP, Chen MZ, Kumana CR, Lai CL, Lai KN, Lam KSL, Lam WK ed., Problem-Based Medical Cases Management. Hong Kong University Press, 2005, 75-107.

 

Lai C.L., Han K.H., Yoon S.K., Um S.H., Yuen R.M.F., Kim H.S., Kim H.R., Chung H.C., Kim C.R., Hsyu P., Averett D., Worland S. and Kim J., Phase II, multi-centre, dose-escalating study of LB80380 (ANA380) in hepatitis B patients with lamivudine-resistant YMDD mutant HBV, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2006, 44 (Suppl 2): S5.

 

Lai C.L. and Yuen R.M.F., Treatment of HBeAg-positive chronic hepatitis B patients., In: Arroyo V, Navasa M, Forns X, Bataller R, Sanchez-Fueyo A, Rodes M ed., Update in treatment of liver disease. Ars Medica, Barcelona, Spain., 2005, 227-233.

 

Lim S.G., Lai C.L., Myers M., Yuen R.M.F., Wai C.T., Lyoyd D., Pietropaolo K., Zhou X.J., Chao G. and Brown N.A., Final results of a phase I/II dose escalation trial of valtorcitabine in patients with chronic hepatitis B., Journal of hepatology : the journal of the European Association for the Study of the Liver. 2005, 42 (Suppl 2): 16.

 

Lo C.M., Cheung C.K.Y., Lau G., Yuen R.M.F., Liu C.L., Chan S.H.C., Fan S.T. and Wong J., Significance of hepatitis B virus genotype in liver transplantation for chronic hepatitis B, American Journal of Transplantation. Blackwell, 2005, 5: 1893-900.

 

Orito E., Fujiwara K., Tanaka Y., Yuen R.M.F., Lai C.L., Kato T., Sugauchi F., Kusakabe A., Sata M., Okanoue T., Niitsuma H., Sakugawa H., Hasegawa I. and Mizokami M., A case-control study of response to lamivudine therapy for 2 years in Japanese and Chinese patients chronically infected with hepatitis B virus of genotypes Bj, Ba and C, Hepatology Research. 2006, 35: 127-134.

 

Sum S.M., Wong D.K.H., Yuen J.C.H., Lai C.L. and Yuen R.M.F., Comparison of the COBAS TaqMan HBV Test with the COBAS Amplicor Monitor Test for Measurement of Hepatitis B Virus DNA in Serum, Journal of Medical Virology. 2005, 77: 486-490.

 

Tanaka Y., Kurbanov F., Mano S., Orito E., Vargas V., Esteban J.I., Yuen R.M.F., Lai C.L., Kramvis A., Kew M.C., Smuts H.E., Netesov S.V., Alter H.J. and Mizokami M., Molecular Tracing of the Global Hepatitis C Virus Epidemic Predicts Regional Patterns of Hepatocellular Carcinoma Mortality, Gastroenterology. 2006, 130: 703-714.

 

Tanaka Y., Kurbanov F., Vargas V., Esteban J., Yuen R.M.F., Lai C.L., Kramvis A., Kew M., Alter H.J. and Mizokami M., Molecular tracing of the global hepatitis C virus epidemic predicts regional patterns of hepatocellular carcinoma mortality, Hepatology. 2005, 42 (Suppl 1): 434A.

 

Tanaka Y., Orito E., Yuen R.M.F., Mukaide M., Sugauchi F., Ito K., Ozasa A., Sakamoto T., Kurbanov F., Lai C.L. and Mizokami M., Two Subtypes (Subgenotypes) of Hepatitis B Virus Genotype C: A Novel Subtyping Assay Based on Restriction Fragment Length Polymorphism, Hepatology Research. 2005, 33: 216-224.

 

Wang J., Peng Y., Sun Y., He H., Zhu S., An X.M., Li M., Lin M.C., Zou B., Xia H.H.X., Jiang B., Chan O.O., Yuen R.M.F., Kung H.F. and Wong B.C.Y., All-Trans Retinoic Acid Induces XAF1 Expression Through an Interferon Regulatory Factor-1 Element in Colon Cancer, Gastroenterology. 2006, 130(3): 747-758.

 

Wong D.K.H., Yuen R.M.F., Tanaka Y., Lai C.L., Kwok C.L. and Mizokami M., Correlation between Hepatitis B virus core-related antigens and intrahepatic covalently closed circular DNA levels, Hepatology. 2005, 42 (Suppl 1): 712A.

 

Wong D.K.H., Tanaka Y., Lai C.L., Mizokami M. and Yuen R.M.F., Detection of hepatitis B virus core-related antigens as a marker for the monitoring of viral activity during nucleoside analogue therapy, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2006, 44 (Suppl 2): S192.

 

Wong D.K.H., Yuen R.M.F., Ngai W.S. and Lai C.L., One-year treatment of entecavir results in reduction in intrahepatic covalently closed circular DNA level, Hepatology. 2005, 42(Suppl 1): 573A.

 

Xia B., Xia H.H.X., Ma C.W., Wong K.W., Fung F.M.Y., Hui C.K., Chan C.K., Chan O.O., Lai K.C., Yuen R.M.F. and Wong B.C.Y., Trends in the prevalence of peptic ulcer disease and Helicobacter pylori infection in family physician-referred uninvestigated dyspeptic patients in Hong Kong. , Alimentary Pharmacology and Therapeutics. 2005, 22(3): 243-9.

 

Yuan H., Yuen R.M.F., Wong D.K.H., Sum S.M., Sablon E., Ng I.O.L. and Lai C.L., Impact of Precore and Core Promoter Mutations on Hepatic Histology in Patients with Chronic Hepatitis B, Alimentary Pharmacology and Therapeutics. 2005, 22: 301-307.

 

Yuan H.J., Yuen R.M.F., Wong D.K.H., Sablon E. and Lai C.L., The relationship between HBV-DNA levels and cirrhosis-related complications in Chinese with chronic hepatitis B, Journal of Viral Hepatitis. 2005, 12: 373-379.

 

Yuen R.M.F., 2005 Outstanding Young Researcher Award, The University of Hong Kong. 2005.

 

Yuen R.M.F., Tanaka Y., Ng I.O.L., Mizokami M., Yuen J.C.H., Wong D.K.H., Yuan H., Sum S.M., Chan O.O. and Lai C.L., Hepatic necroinflammation and fibrosis in patients with genotypes Ba and C, core-promoter and precore mutations, Journal of Viral Hepatitis . 2005, 12(5): 513-8.

 

Yuen R.M.F., Wong D.K.H., Chan C.C.S., Zheng B.J., Yuen J.C.H. and Lai C.L., Immune response during immunoclearance phase of Chinese patients with HBV genotypes B and C., Journal of hepatology : the journal of the European Association for the Study of the Liver. 2005, 42 (Suppl 2): 152.

 

Yuen R.M.F., Seto W.K., Chow D.H.F., Tsui K., Wong D.K.H., Chan P., But D. and Lai C.L., Long-term beneficial outcome of Chinese asymptomatic patients with HBeAg-positive chronic hepatitis B on continuous lamivudine therapy: 7-year experience., Hepatology. 2005, 42 (4 Suppl 1): 583A.

 

Yuen R.M.F., Yuan H., Wong D.K.H., Yuen J.C.H., Wong R.W.M., Chan O.O., Wong B.C.Y., Lai K.C. and Lai C.L., Prognostic determinants for chronic hepatitis B in Asians: therapeutic implications. , Gut. 2005, 54(11): 1610-4.

 

Yuen R.M.F. and Lai C.L., Response to combined interferon and ribavirin is better in patients infected with hepatitis C virus genotype 6 than genotype 1 in Hong Kong. , Intervirology. 2006, 49(1-2): 96-8.

 

Yuen R.M.F., Sablon E., Libbrecht E., Van de Velde H., Wong D.K.H., Fung J.Y.Y., Wong B.C.Y. and Lai C.L., Significance of HBV DNA, core promoter/precore mutations, genotypes, specific sequences of polymerase gene on three-year lamivudine treatment: A predictive model for antiviral therapy, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2006, 44 (Suppl 2): S194.

 

Yuen R.M.F. and Lai C.L., Telbivudine: an upcoming agent for chronic hepatitis B. , Expert Rev Anti Infect Ther. 2005, 3(4): 489-94.

 

Researcher : Yueng YH



List of Research Outputs

 

Hui C.K., Cheung W., Au W.Y., Lie A.K.W., Zhang H., Yueng Y.H., Wong B.C.Y., Leung N., Kwong Y.L., Liang R.H.S. and Lau G., Hepatitis B reactivation after withdrawal of preemptive lamivudine in patients with hematological malignancy upon completion of cytotoxic chemotherapy, Liver International 2005. 2005, Oct: 182.

 

Hui C.K., Cheung W.W., Zhang H., Au W.Y., Yueng Y.H., Leung A.Y.H., Leung N., Luk J.M.C., Lie A.K.W., Kwong Y.L., Liang R.H.S. and Lau G., Kinetics and risk of de novo hepatitis B infection in HBsAg negative patients undergoing cytotoxic chemotherapy, Gastroenterology. 2006, 131: 59-68.

 

Hui C.K., Cheung W.W., Zhang H., Au W.Y., Yueng Y.H., Leung A.Y.H., Leung N., Luk J.M.C., Lie A.K.W., Kwong Y.L., Liang R.H.S. and Lau G., Rituximab increases the Risk of De Novo hepatitis B infection in Hepatitis B Surface Antigen Negative Patients Undergoing Cytotoxic Chemotherapy, J Gastroenterol and Hepatol. 2006, 21(2): A73.

 

Lu L., Hui C.K., Zhang H., Yueng Y.H., Cheung K.F. and Lau G., Quantification and Correlation of HBV DNA and RNA inPeripheral Blood Mononuclear Cells adn HBV DNA in Serum in Chronic Hepatitis B, J Gastroenterol and Hepatol. 2006, 21(2): A77.

 

Researcher : Yung LY



List of Research Outputs

 

Yiu K.H., Miu R., Lee K.L.F., Yung L.Y., Siu C.W.D., Tse H.F., Lam B., Lam J., Ip M.S.M. and Lau C.P., Improvement of sleep Apnea in heart failure patients after cardiac resynchronization therapy is associated with a significant dop in pulmonary arterial pressure, Heart Rhythm. 2006, 3, No. 5: S87.

 

Researcher : Yung SSY



Project Title:

The role of hyaluronan and cytoskeletal proteins in mediating human peritoneal mesothelial cell transdifferentiation during peritoneal dialysis

Investigator(s):

Yung SSY, Chan DTM

Department:

Medicine

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

02/2004

Completion Date:

01/2006

 

Abstract:

To isolate human peritoneal mesothelial cells (HPMC) in spent PD fluid obtained from patients on long-term PD, and to determine the ratio of non-transdifferentiated and transdifferentiated mesothelial cells. The cell morphology and cytoskeleton will be compared with normal HPMC isolated from omental specimens from non PD patients during abdominal surgery; to assess hyaluronan synthesis (at transcription and translation) during mesothelial cell transformation; to determine concomitant changes in the cytoskeleton (vimentin, cytokeratin, and [alpha]-smooth muscle actin), and epithelial markers (E-cadherin , occludin ZO-1).

 

Project Title:

The role of thrombospondin-1 in the activation of TGF-beta1, and synthesis of matrix proteins in human proximal tubular epithelial cells under elevated glucose concentrations - implications in diabetic nephropathy

Investigator(s):

Yung SSY, Chan DTM

Department:

Medicine

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

02/2005

Completion Date:

01/2007

 

Abstract:

Background Nephropathy in patients with type I and II diabetes mellitus is a rapidly increasing problem worldwide, and is the most important cause of end-stage renal failure, accounting for 40% of new patients who require renal replacement therapy (1). The incidence of diabetic nephropathy (DN) will continue to increase, attributed in part by the improved survival of type II patients as the cardiovascular mortality in this group declines (2). DN is initiated by hyperglycaemia and characterized by cell proliferation, and thickening of tubular and glomerular basement membranes due to an excessive accumulation of extracellular matrix proteins that ultimately results in progressive scarring and fibrosis of the kidney (3). Clinically, DN manifests itself by the onset of continuous microalbuminuria followed by the appearance of persistent proteinuria. This is subsequently followed by a progressive decline in glomerular filtration rate leading to end-stage renal failure (4). Although DN was traditionally considered to be primarily a glomerular disease, recent studies have demonstrated that the rate of kidney function deterioration correlates best with the degree of tubulo-interstitial fibrosis (5). This therefore suggests that although glomerular changes are predominantly observed in diabetic patients, the long-term outcome is determined by events in the tubulo-interstitium. Proximal tubular epithelial cells (PTEC) constitutes the predominant cell type within the tubulo-interstitium. Although previously considered to be mainly involved in the transport of fluid and electrolytes, there is increasing evidence that they play a critical role in the immunopathogenesis of various renal parenchymal diseases, and act as a regulator/effector of immune-mediated inflammation and fibrosis (6). Thus, PTEC are not only affected secondary to glomerular injury, but are primary targets for pathological influences in DN. Animal and in vitro studies have shown that under elevated glucose concentrations, PTEC can directly contribute to the pathogenesis of renal fibrosis by induced synthesis of extracellular matrix proteins such as collagen type I and fibronectin through the enhanced secretion of the pro-fibrotic growth factor transforming growth factor-beta1 (TGF-beta1) (7-9). TGF-beta1 is normally synthesized and secreted in its latent form, and thus must be activated before it can bind to its receptors. Thus, changes in the expression of latent TGF-beta1 will have no biologic effect on the kidney parenchyma unless mechanisms are present to convert it to the active form. In the latent form, TGF-beta1 is non-covalently associated with a disulfide-linked dimer of the N-terminal part of the TGF-beta1 molecule, referred to as the latency-associated peptide (LAP). Physicochemical activation can occur by extreme pH or high temperature (10), limited proteolysis or deglycosylation of LAP (11), or binding to various membrane or extracellular matrix components. Activation in vivo is more complex and not well understood. Studies have documented that the extracellular matrix molecule thrombospondin-1 (TSP-1) is associated with TGF-beta1 as an active complex in stimulated platelets (12). Furthermore, TSP-1 has been shown to precede the development of tubulo-interstitial fibrosis in glomerular disease, and recent studies have shown TSP-1 to be the key activator of this pro-fibrotic peptide in human mesangial cells after exposure to elevated glucose concentrations (13-15). How TGF-beta1 is activated in PTEC in DN has not been investigated. We hypothesize that TSP-1 may activate TGF-beta1 in PTEC and contribute to tubulo-interstitial fibrosis. The objectives of this project are thus: 1. To assess PTEC proliferation and viability under physiological and elevated glucose concentrations pertaining to DN. 2. To assess gene expression and protein translation of TGF-beta1, matrix proteins (fibronectin, collagen type I, III and IV) and TSP-1 under different glucose concentrations, and correlate TSP-1 synthesis with TGF-beta1 activation and matrix protein synthesis.. 3. To determine the bioactivity of TGF-beta1 secreted under control and elevated glucose concentrations. 4. To examine the effect of exogenous TSP-1 on TGF-beta1 bioactivity and matrix protein synthesis in PTEC, and to determine whether TSP-1 can directly modulate matrix synthesis or act only through induction of TGF-beta1 activation. References 1. Gilbert RE, Cooper ME. Kidney Int. 1999; 56: 1627-1637. 2. Ritz E, Stefanski A. Am J Kidney Dis. 1996; 27: 167-194. 3. Amos AF, McCarty DJ, Zimmet P. Diabet Med. 1997; 14: S1-S85. 4. Phillips AO, Steadman R. Histol Histopathol. 2002; 17: 247-252. 5. Bohle A, Wehrmann M, Bogenschutz O, Batz C, Muller CA, Muller GA. Pathol Res Pract. 1991; 187: 251-259. 6. Tang WW, Feng L, Xia Y, Wilson CB. Kidney Int. 45: 1994; 1077-1084. 7. Phillips AO, Steadman R, Topley N, Williams JD. Am J Pathol. 1995; 147: 362-374. 8. Phillips AO, Steadman R, Morrisey K, Martin J, Eynstone L, Williams JD. Kidney Int. 1997; 52: 973-984. 9. Morrisey K, Steadman R, Williams JD, Phillips AO. Kidney Int. 1999; 55: 2548-2572. 10. Brown PD, Wakefield LM, Levinson AD, Sporn MB. Growth Factors 1990; 3: 35-43. 11. Lyons R, Gentry LE, Purchio AF, Moses HL. J Cell Biol. 1990; 110: 1361-1367. 12. Murphy-Ullrich JE, Schultz-Cherry S, Hook M. Mol Biol Cell. 1992; 3: 181-188. 13. Poczatek MH, Hugo C, Darley-Usmar V, Murphy-Ullrich JE. Am J Pathol. 2000; 157: 1353-1363. 14. Yevdokimova N, Abdel Wahab N, Mason RM. J Am Soc Nephrol. 2001; 12: 703-712. 15. Hugo C, Shankland SJ, Pichler RH, Couser WG, Johnson RJ. Kidney Int. 1998; 53: 302-311.

 

List of Research Outputs

 

Chan D.T.M., Tsang R.C.W., Zhang Q. and Yung S.S.Y., Mycophenolic Acid Reduces Matrix Synthesis in Human Mesangial Cells Stimulated with Anti-DNA Antibodies, Journal of the American Society of Nephrology. 2005, 16: 420A.

 

Lui S.L., Chan K.W., Tsang R.C.W., Yung S.S.Y., Lai K.N. and Chan D.T.M., Effect of rapamycin on renal ischemia reperfusion injury, Joint symposium on extracorporeal support for multi-organ failure organized by Hong Kong College of Physicians Scientific Symposium and Hong Kong Society of Nephrology Annual Scientific Meeting, 10-11 September 2005, Hong Kong. 2005.

 

Yung S.S.Y., Zhang Q., Tsang R.C.W. and Chan D.T.M., Binding and internalisation of anti-DNA antibodies induce altered cellular functions in human mesangial cells - implications in the pathogenesis of lupus nephritis, 11th Medical Research Conference, 14 January, 2006. 49.

 

Yung S.S.Y., Tsang R.C.W., Sun Y., Leung J.K.H. and Chan D.T.M., Effect of Human Anti-DNA Antibodies on Proximal Renal Tubular Epithelial Cell Cytokine Expression: Implication on Tubulointerstitial Inflammation in Lupus Nephritis, Journal of the American Society of Nephrology. 2005, 16: 3281-3294.

 

Yung S.S.Y., Lee Y.Y.C., Zhang Q., Leung J.K.H., Lau S.K., Tsang R.C.W. and Chan D.T.M., Elevated glucose concentrations induce thrombospondin-1 synthesis in proximal renal tubular epithelial cells thereby stimulating fibronectin synthesis through TGF-b1 dependent and TGF-b1 independent pathways, Nephrology Dialysis Transplantation. 2006, 21: 1504-1513.

 

Yung S.S.Y. and Chan D.T.M., Glucose degradation products and the peritoneum - how sweet things can turn bitter, Peritoneal Dialysis International. 2006, 26: 309-313.

 

Yung S.S.Y., Tsang R.C.W., Leung J.K.H. and Chan D.T.M., Increased mesangial cell hyaluronan expression during active lupus nephritis is mediated by anti-DNA antibody-induced IL-1beta, Kidney International. 2006, 69(2): 272-280.

 

Yung S.S.Y., Li F.K. and Chan D.T.M., Peritoneal mesothelial cell culture and biology, Peritoneal Dialysis International. 2006, 26(2): 162-173.

 

Yung S.S.Y., Lee Y.Y.C., Zhang Q., Tsang R.C.W. and Chan D.T.M., Thrombospondin-1 Induced by High Glucose Concentration Mediates Fibronectin Synthesis in Proximal Renal Tubular Epithelial Cells Through Both TGF-beta1 Dependent and TGF-beta1 Independent Pathways, Journal of the American Society of Nephrology. 2005, 16: 662A.

 

Researcher : Zeng H



List of Research Outputs

 

Zou B., Chim J.C.S., Lin M.C., Zeng H., He H., Yu L., Sun Y., Jiang S.H. and Wong B.C.Y., Correlation between the single-site CpG mutation within the gene promoter and the expression silencing of XIAP -Associated Factor 1 (XAF1) in human colon cancer cell lines. Asian Pacific Digestive Week, Sept. 25-28, 2005, Seoul, Korea., Journal of Gastroenterology and Hepatology. 2005, 20: Supp A253.

 

Zou B., Chim J.C.S., Lin M.C., Zeng H., He H., Yu L., Sun Y., Jiang S.H. and Wong B.C.Y., Distinguished Poster Award, "Correlation between the single-site CpG mutation within the gene promoter and the expression silencing of XIAP -Associated Factor 1 (XAF1) in human colon cancer cell lines" , Asian Pacific Digestive Week, Sept. 25-28, Seoul, Korea. 2005.

 

Zou B., Lin M.C., Lam S.K., Tu S., Zeng H., Yang Y., Wang J., He H., Jiang S.H., Kung H. and Wong B.C.Y., Distinguished Poster Award, "Hypermethylation status around exon 1 of XIAP-Associated Factor 1(XAF1) in human gastric and colon cancer cell line.", Asian Pacific Digestive Week, Sept. 25-28, Seoul, Korea.. 2005.

 

Zou B., Lin M.C., Lam S.K., Tu S., Zeng H., Yang Y., Wang J., He H., Jiang S.H., Kung H. and Wong B.C.Y., Hypermethylation status around exon 1 of XIAP-Associated Factor 1(XAF1) in human gastric and colon cancer cell line. Asian Pacific Digestive Week, Sept. 25-28, 2005, Seoul, Korea. , Journal of Gastroenterology and Hepatology. 2005, 20: Supp A370.

 

Researcher : Zhang D



List of Research Outputs

 

Zhang D., Lau C.P. and Li G.R., A depolarization-induced transient outward component in inward-rectifier potassium current is regulated by intracellular Mg2+ and spermine. , Journal of Hong Kong College Cardiology/The 9th Institute of Cardiovascular Science and Medicine & the 5th Scientific Conference on Cardiovascular Science Across the Strait. 2005, 13:130-OP130.

 

Zhang D., Lau C.P. and Li G.R., A depolirization-activated transient outward current is contributed by recombinant human cardiac Kir2.1 channels expressed in HEK 293 cells , 10th Research Postgraduate Symposium, Faculty of Medicine, HKU. 2005.

 

Zhang D., Lau C.P. and Li G.R., Regulation of human cardiac inwardly-rectifying Kir2.1 channels by tyrosine kinase phosphorylation, 11th Medical Research Conference, The University of Hong Kong/Queen Mary Hospital. 2006.

 

Researcher : Zhang H



List of Research Outputs

 

Hui C.K., Lai L.S., Lam P., Zhang H., Fung T.T., Lai S.T., Wong W.M., Lo C.M., Fan S.T., Leung N. and Lau G., 48 weeks pegylated interferon alpha-2a is superior to 24 weeks of pegylated interferon alpha-2b in achieving hepatitis B e antigen seroconversion in chronic hepatitis B infection, Alimentary Pharmacology and Therapeutics. 2006, 23(8): 1171-1178.

 

Hui C.K., Lie A.K.W., Au W.Y., Leung A.Y.H., Ma S.Y., Cheung W.W., Zhang H., Chim J.C.S., Kwong Y.L., Liang R.H.S. and Lau G., A long-term follow-up study on hepatitis B surface antigen-positive patients undergoing allogeneic hematopoietic stem cell transplantation, Blood. 2005, 106(2): 464-9.

 

Hui C.K., Bowden S., Zhang H., Wong A., Lewin S., Rousseau F., Mommeja-Marin H., Lee N.P., Luk J.M., Leung N., Naoumov N.V. and Lau G., Comparison of Real-Time PCR Assays for Monitoring serum HBV DNA levels during Antiviral Therapy, Journal of Clincial Microbiology. 2006, 44: 2983-2987.

 

Hui C.K., Cheung W., Au W.Y., Lie A.K.W., Zhang H., Yueng Y.H., Wong B.C.Y., Leung N., Kwong Y.L., Liang R.H.S. and Lau G., Hepatitis B reactivation after withdrawal of preemptive lamivudine in patients with hematological malignancy upon completion of cytotoxic chemotherapy, Liver International 2005. 2005, Oct: 182.

 

Hui C.K., Cheung W.W., Zhang H., Au W.Y., Yueng Y.H., Leung A.Y.H., Leung N., Luk J.M.C., Lie A.K.W., Kwong Y.L., Liang R.H.S. and Lau G., Kinetics and risk of de novo hepatitis B infection in HBsAg negative patients undergoing cytotoxic chemotherapy, Gastroenterology. 2006, 131: 59-68.

 

Hui C.K., Cheung W.W., Zhang H., Au W.Y., Yueng Y.H., Leung A.Y.H., Leung N., Luk J.M.C., Lie A.K.W., Kwong Y.L., Liang R.H.S. and Lau G., Rituximab increases the Risk of De Novo hepatitis B infection in Hepatitis B Surface Antigen Negative Patients Undergoing Cytotoxic Chemotherapy, J Gastroenterol and Hepatol. 2006, 21(2): A73.

 

Hui C.K., Zhang H., Lee N.W., Lu L., Leung N., Wong B.C.Y., Lo C.M., Fan S.T., Luk J.M.C. and Lau G., Upregulation of toll-like receptor 7 is essential for serological clearance of hepatitis B surface antigen in chronic hepatitis B virus (HBV) infection, Liver International 2005. 2005, Oct: 196.

 

Jin Y., Feng H., Deng W., Zhang H., Lu M., Jin C., Tsao G.S.W. and Kwong Y.L., Immortalization of human extravillous cytotrophoblasts by human papilloma virus gene E6E7: sequential cytogenetic and molecular genetic characterization, Cancer Genetics and Cytogenetics. 2005, 163: 30-37.

 

Lai L.S.W., Fung T.T., Lai S.T., Yiu J., Lam P., Zhang H., Wong W.M., Lo C.M., Fan S.T., Hui C.K., Leung N. and Lau G., 48 weeks pegylated interferon alfa-2a is superior to 24 weeks of pegylated interferon alfa-2b in achieving HBeAg seroconversion in chronic hepatitis B infection (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A90.

 

Lu L., Hui C.K., Zhang H., Yueng Y.H., Cheung K.F. and Lau G., Quantification and Correlation of HBV DNA and RNA inPeripheral Blood Mononuclear Cells adn HBV DNA in Serum in Chronic Hepatitis B, J Gastroenterol and Hepatol. 2006, 21(2): A77.

 

Zhang H., Hui C.K., Wong A., Lee N.P., Leung N., Luk J.M.C. and Lau G., Comparison of Real-Time PCR Assays for monitoring Serum HBV DNA Levels During Antiviral Therapy, J Gastroenterol and Hepatol. 2006, 21(2): A140.

 

Zhang H., Jin Y., Chen X., Jin C., Law S.Y.K., Tsao G.S.W. and Kwong Y.L., Cytogenetic aberrations in immortalization of esophageal epithelial cells, Cancer Genetics and Cytogenetics. 2006, 165(1): 25-35.

 

Researcher : Zhang H



List of Research Outputs

 

Hui C.K., Lai L.S., Lam P., Zhang H., Fung T.T., Lai S.T., Wong W.M., Lo C.M., Fan S.T., Leung N. and Lau G., 48 weeks pegylated interferon alpha-2a is superior to 24 weeks of pegylated interferon alpha-2b in achieving hepatitis B e antigen seroconversion in chronic hepatitis B infection, Alimentary Pharmacology and Therapeutics. 2006, 23(8): 1171-1178.

 

Hui C.K., Lie A.K.W., Au W.Y., Leung A.Y.H., Ma S.Y., Cheung W.W., Zhang H., Chim J.C.S., Kwong Y.L., Liang R.H.S. and Lau G., A long-term follow-up study on hepatitis B surface antigen-positive patients undergoing allogeneic hematopoietic stem cell transplantation, Blood. 2005, 106(2): 464-9.

 

Hui C.K., Bowden S., Zhang H., Wong A., Lewin S., Rousseau F., Mommeja-Marin H., Lee N.P., Luk J.M., Leung N., Naoumov N.V. and Lau G., Comparison of Real-Time PCR Assays for Monitoring serum HBV DNA levels during Antiviral Therapy, Journal of Clincial Microbiology. 2006, 44: 2983-2987.

 

Hui C.K., Cheung W., Au W.Y., Lie A.K.W., Zhang H., Yueng Y.H., Wong B.C.Y., Leung N., Kwong Y.L., Liang R.H.S. and Lau G., Hepatitis B reactivation after withdrawal of preemptive lamivudine in patients with hematological malignancy upon completion of cytotoxic chemotherapy, Liver International 2005. 2005, Oct: 182.

 

Hui C.K., Cheung W.W., Zhang H., Au W.Y., Yueng Y.H., Leung A.Y.H., Leung N., Luk J.M.C., Lie A.K.W., Kwong Y.L., Liang R.H.S. and Lau G., Kinetics and risk of de novo hepatitis B infection in HBsAg negative patients undergoing cytotoxic chemotherapy, Gastroenterology. 2006, 131: 59-68.

 

Hui C.K., Cheung W.W., Zhang H., Au W.Y., Yueng Y.H., Leung A.Y.H., Leung N., Luk J.M.C., Lie A.K.W., Kwong Y.L., Liang R.H.S. and Lau G., Rituximab increases the Risk of De Novo hepatitis B infection in Hepatitis B Surface Antigen Negative Patients Undergoing Cytotoxic Chemotherapy, J Gastroenterol and Hepatol. 2006, 21(2): A73.

 

Hui C.K., Zhang H., Lee N.W., Lu L., Leung N., Wong B.C.Y., Lo C.M., Fan S.T., Luk J.M.C. and Lau G., Upregulation of toll-like receptor 7 is essential for serological clearance of hepatitis B surface antigen in chronic hepatitis B virus (HBV) infection, Liver International 2005. 2005, Oct: 196.

 

Jin Y., Feng H., Deng W., Zhang H., Lu M., Jin C., Tsao G.S.W. and Kwong Y.L., Immortalization of human extravillous cytotrophoblasts by human papilloma virus gene E6E7: sequential cytogenetic and molecular genetic characterization, Cancer Genetics and Cytogenetics. 2005, 163: 30-37.

 

Lai L.S.W., Fung T.T., Lai S.T., Yiu J., Lam P., Zhang H., Wong W.M., Lo C.M., Fan S.T., Hui C.K., Leung N. and Lau G., 48 weeks pegylated interferon alfa-2a is superior to 24 weeks of pegylated interferon alfa-2b in achieving HBeAg seroconversion in chronic hepatitis B infection (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A90.

 

Lu L., Hui C.K., Zhang H., Yueng Y.H., Cheung K.F. and Lau G., Quantification and Correlation of HBV DNA and RNA inPeripheral Blood Mononuclear Cells adn HBV DNA in Serum in Chronic Hepatitis B, J Gastroenterol and Hepatol. 2006, 21(2): A77.

 

Zhang H., Hui C.K., Wong A., Lee N.P., Leung N., Luk J.M.C. and Lau G., Comparison of Real-Time PCR Assays for monitoring Serum HBV DNA Levels During Antiviral Therapy, J Gastroenterol and Hepatol. 2006, 21(2): A140.

 

Zhang H., Jin Y., Chen X., Jin C., Law S.Y.K., Tsao G.S.W. and Kwong Y.L., Cytogenetic aberrations in immortalization of esophageal epithelial cells, Cancer Genetics and Cytogenetics. 2006, 165(1): 25-35.

 

Researcher : Zhang J



List of Research Outputs

 

Chen B., Lam K.S.L., Wang Y., Wu D., Lam C.W., Shen J., Wong L.C., Hoo R.L.C., Zhang J. and Xu A., Hypoxia dysregulates the production of adiponectin and plasminogen activator inhibitor-1 independent of reactive oxygen species in adipocytes, Biochem Biophys Res Commun. 2006, 341: 549-56.

 

Sae-Pang J.J., Zhang J., Chan K.T., Tsang W.H., Tsang S.L. and Sham M.H., Analysis of multiple cardiac abnormalities of a mouse mutant Hoxb3lacZ, Mechanisms of Development, 15th International Society of Developmental Biologist Congress 2005, Sydney Australia 3-7 September 2005. 2005.

 

Sae-Pang J.J., Zhang J., Chan K.T., Tsang W.H., Tsang S.L. and Sham M.H., Investigation of Cardiovascular Defects in a Mouse Mutant HOXB3LACZ, 10th Research Postgraduate Symposium, Faculty of Medicine, HKU, December 3, 2005 . 2005.

 

Xu A., Wang Y., Xu J., Stejskal D., Tam S., Zhang J., Wat N.M.S., Wong W.K. and Lam K.S.L., Adipocyte fatty acid-binding protein is a plasma biomarker closely associated with obesity and metabolic syndrome, Clinical Chemistry. 2006, 52: 405-413.

 

Researcher : Zhang JCL



Project Title:

Functional analysis of SM22[beta] by tissue-specific targeted deletion in mice

Investigator(s):

Zhang JCL, Cheah KSE, Lau CP, Feil R., Parmacek M.S.

Department:

Medicine

Source(s) of Funding:

Merit Award for RGC CERG Funded Projects

Start Date:

09/2003

Completion Date:

09/2005

 

Abstract:

N/A

 

Project Title:

Cardiovascular analysis of a novel murine model of cardiomyopathy and sudden death

Investigator(s):

Zhang JCL

Department:

Medicine

Source(s) of Funding:

Incentive Award for RGC CERG Fundable But Not Funded Projects

Start Date:

07/2004

Completion Date:

09/2005

 

Abstract:

N/A

 

List of Research Outputs

 

Cheah K.S.E., Wong S.Y.Y., Zhang J.C.L., Leung W.L., Yip M.S., Leung K.K.H., Dung W.F., Chan D., Shang C., Prall O., Mohun T.J., Harvey R.P. and Tam P.P.L., Procollagen IIA facilitates BMP signaling in heart development, Hugo, HGM2006, 31 May - 3 June 2006 Helsinki, Finland . 2006.

 

Fong S.W., Chan K.W., Zhang J.C.L. and Chan S.Y., Downregulation of Testis Specific Protein Y-encoded like 2 in neonatal heart development, 15th International Soceity of Developmental Biologists Congress 2005, Sydney, Australia, 3-7 September 2005, published in Mechanisms of Development. 2005, 122: S54.

 

Fong S.W., Chan K.W., Zhang J.C.L. and Chan S.Y., Regulation of testis specific protein Y-encoded like 2, a member of nucleosome assembly proteins, in neonatal heart development, 10th Research Postgraduate Symposium , Faculty of Medicine, HKU, 3 December 2005. 105.

 

Wang K., Xue T., Tsang S.Y., Huizen R.V., Wong C.W., Lai K.W.H., Ye Z., Cheng L., Zhang J.C.L., Li G.R., Lau C.P., Tse H.F. and Li R.A., Electrophysiological Properties of Pluripotent Human and Mouse Embryonic Stem Cells, Stem Cells. 2005, 23: 1526-1534.

 

Researcher : Zhang Q



List of Research Outputs

 

Chan D.T.M., Tsang R.C.W., Zhang Q. and Yung S.S.Y., Mycophenolic Acid Reduces Matrix Synthesis in Human Mesangial Cells Stimulated with Anti-DNA Antibodies, Journal of the American Society of Nephrology. 2005, 16: 420A.

 

Yung S.S.Y., Zhang Q., Tsang R.C.W. and Chan D.T.M., Binding and internalisation of anti-DNA antibodies induce altered cellular functions in human mesangial cells - implications in the pathogenesis of lupus nephritis, 11th Medical Research Conference, 14 January, 2006. 49.

 

Yung S.S.Y., Lee Y.Y.C., Zhang Q., Leung J.K.H., Lau S.K., Tsang R.C.W. and Chan D.T.M., Elevated glucose concentrations induce thrombospondin-1 synthesis in proximal renal tubular epithelial cells thereby stimulating fibronectin synthesis through TGF-b1 dependent and TGF-b1 independent pathways, Nephrology Dialysis Transplantation. 2006, 21: 1504-1513.

 

Yung S.S.Y., Lee Y.Y.C., Zhang Q., Tsang R.C.W. and Chan D.T.M., Thrombospondin-1 Induced by High Glucose Concentration Mediates Fibronectin Synthesis in Proximal Renal Tubular Epithelial Cells Through Both TGF-beta1 Dependent and TGF-beta1 Independent Pathways, Journal of the American Society of Nephrology. 2005, 16: 662A.

 

Researcher : Zhang Q



List of Research Outputs

 

Chan D.T.M., Tsang R.C.W., Zhang Q. and Yung S.S.Y., Mycophenolic Acid Reduces Matrix Synthesis in Human Mesangial Cells Stimulated with Anti-DNA Antibodies, Journal of the American Society of Nephrology. 2005, 16: 420A.

 

Yung S.S.Y., Zhang Q., Tsang R.C.W. and Chan D.T.M., Binding and internalisation of anti-DNA antibodies induce altered cellular functions in human mesangial cells - implications in the pathogenesis of lupus nephritis, 11th Medical Research Conference, 14 January, 2006. 49.

 

Yung S.S.Y., Lee Y.Y.C., Zhang Q., Leung J.K.H., Lau S.K., Tsang R.C.W. and Chan D.T.M., Elevated glucose concentrations induce thrombospondin-1 synthesis in proximal renal tubular epithelial cells thereby stimulating fibronectin synthesis through TGF-b1 dependent and TGF-b1 independent pathways, Nephrology Dialysis Transplantation. 2006, 21: 1504-1513.

 

Yung S.S.Y., Lee Y.Y.C., Zhang Q., Tsang R.C.W. and Chan D.T.M., Thrombospondin-1 Induced by High Glucose Concentration Mediates Fibronectin Synthesis in Proximal Renal Tubular Epithelial Cells Through Both TGF-beta1 Dependent and TGF-beta1 Independent Pathways, Journal of the American Society of Nephrology. 2005, 16: 662A.

 

Researcher : Zhao Y



Project Title:

Development of an in vitro assay for methylation-dependent genetic mutation based on linking in-frame CGA polynucleotides to the alpha-lacZ reporter gene system

Investigator(s):

Zhao Y, Epstein R

Department:

Medicine

Source(s) of Funding:

Small Project Funding

Start Date:

11/2005

 

Abstract:

CpG dinucleotides in human DNA can be uniquely modified by cytosine methyltransferases, yielding the 'fifth base' of DNA, 5-methylcytosine (5MC). 5MC residues clustered within CpG islands act as binding sites for linker proteins that recruit histone deacetylases, thus triggering chromatin condensation and transcriptional repression that is epigenetically transmissible via either germline or somatic cells. If the cell tolerates longterm transcriptional repression of such genes, 5MC residues within the coding sequence may persist in the absence of transcription-coupled repair; since oxidant deamination of 5MC yields thymidine (T), CpG methylation predisposes to a ten-fold excess of CG to TA transitional mutations within the coding sequence as a 'marker' or 'fossil' of repressed transcription (Rideout et al, 1990; Soussi, et al, 2003). Yet despite this insight, little is known as to the dynamics and function of CpG sites in the open reading frame of tumor suppressor genes (TSGs, e.g., p53; Rodin et al, 1998). Our recent work has confirmed that the CGA codon specifying arginine is specifically associated with a pronounced mutational asymmetry in TSGs associated with familial cancer syndromes, consistent with the observation that this codon is unique in its ability to undergo a single-base methylation-dependent mutation to a stop codon (viz., CGA  TGA; Table 1). Table 1 Asymmetry pattern of CGN germline mutations in human TSGs Gene CGA CGT CGC CGG TGA CAA TGT CAT TGC CAC TGG CAG APC 125** 0 0 0 1 0 3 0 TP53 10** 0 12 10 38 3 16 17 RB1 126** 0 0 0 0 0 0 0 MLH1 26** 0 0 0 0 0 0 0 VHL 18* 7 0 0 1 0 24 28 ATM 4 0 0 0 4 0 0 2 MSH2 6* 0 0 0 0 0 0 0 ** p < 0.001, p < 0.05, based on binomial distribution. Further evidence for the biological significance of the CGA codon is the finding that it is topographically clustered within TSGs such as p53, unlike other arginine-encoding codons: Table 2 Clustered CGA(CGN) codons in TP53 gene* Codons CGA CGG AGA AGG Codon position 196, 213, 306, 342 248, 267, 282 65, 209, 280 174, 249, 363 Cluster parameter h(2,4,392,18) h(3,3,392,99) h(2,3,392,145) h(2,3,392,76) and p value 0.0110 0.0157 0.2588 0.0904 h(2,4,392,37) h(2,3,392,72) h(2,3,392,114) 0.0432 0.0821 0.1797 h(4,4,392,147) h(3,3,392,216) h(3,3,392,189) 0.0193 0.1663 0.1112 (*Data calculated without assuming a hypergeometric distribution) Such CGA clustering is similarly evident in other TSGs such as RB1 and APC, with the distribution of clusters suggesting a 'mutational splicing' significance (data not shown). Hence, the position of the CGA clusters tends to separate the gene into loss-of-function subunits (e.g., in TP53, the 196/212 and 306/342 CGA clusters demarcate the DNA-binding domain, which also participates in mitochondrial apoptosis). We therefore speculate that CGA clustering represents a methylation-dependent genotype that is evolutionarily advantageous for the species (favouring adaptability) but hazardous for individuals (favouring genetic instability and, hence, loss of TSG function leading to clonal microevolution of cancer). Hence, in this small project application, we seek to explore a new hypothesis: namely, that the unique vulnerability of CGA codons to methylation-dependent nonsense (TGA) mutation can be exploited (i) to form the basis for a mutational assay based on the well-known alpha-lacZ reporter gene system used to investigate cancer and ageing in transgenic mouse models, and thus (ii) to clarify the oncogenetic role of CGA. The objectives of this funding application are: 1. To exploit the foregoing insights regarding the CGA codon to develop a useful, and potentially patentable, in vitro assay system for methylation-dependent mutation; 2. To exemplify the assay using conditions that will putatively favour or inhibit DNA methylation, forming the basis of a peer-reviewed publication in the epigenetic field; 3. To use this assay (+/- patent) and submission/publication to compete for a 2006 RGC grant in which we will propose to develop an in vivo CGA-LacZ-based transgenic mouse model system of methylation-dependent mutation and/or ageing; 4. To permit continuation of the laboratory programme over the next 12 months while awaiting publication of manuscripts to support external funding applications in 2006. References 1. Soussi T, Beroud C. (2003) Significance of TP53 mutations in human cancer: a critical analysis of mutations at CpG dinucleotides. Hum Mutat. 21(3):192-200. 2. Rideout WM 3rd, Coetzee GA, Olumi AF, Jones PA.(1990) 5-Methylcytosine as an endogenous mutagen in the human LDL receptor and p53 genes. Science. 249(4974):1288-90. 3. Rodin SN, Rodin AS.(1998) Strand asymmetry of CpG transitions as indicator of G1 phase-dependent origin of multiple p53 mutations in stem cells. Proc Natl Acad Sci U S A. 95(20):11927-32.

 

List of Research Outputs

 

Epstein R. and Zhao Y., Programmed Genetic Instability Revealed By Adaptive Evolution Of Caretaker Tumour Suppressor Genes, 97th Annual Meeting, American Association For Cancer Research, Washington, DC. 2006.

 

Epstein R. and Zhao Y., Racial Differences In Lung Cancer, The New England Journal Of Medicine. USA, Massachusetts Medical Society, 2006, 354: 1951-1952.

 

Ge L. and Zhao Y., Age estimation based on telomeric restricted fragment length of human peripheral white blood cells, The 17th Meeting of the International Association of Forensic Sciences (IAFS 2005), 21-26 August 2005, Hong Kong Convention and Exhibition Centre . Hong Kong, International Association of Forensic Sciences, 2005, P05.

 

Wang Y., Wang H., Guo H., Zhao Y. and Luo S., Analysis of ERG11 gene mutation in Candida albicans, Di Yi Jun Yi Da Xue Xue Bao. Guangzhou, South Medical University, 2005, 25: 1390-3.

 

Zhang M., Ma H., Wang B. and Zhao Y., Angiotensin II Type 2 Receptor Gene Polymorphisms And Cardioprotective Role In Essential Hypertension, Heart and Vessels. Germany, Springer-Verlag, 2006, 21: 95-101.

 

Researcher : Zheng G



List of Research Outputs

 

Wang W., Huang J., Zheng G., Xia H.H.X., Wong R.W.M., Lam S.K. and Wong B.C.Y., Head-to-Head Comparison of H2-Receptor Antagonists and Proton Pump Inhibitors in the Treatment of Erosive Esophagitis: A Meta-Analysis, World Journal of Gastroenterology. 2005, 11(26): 4067-4077.

 

Researcher : Zhou H



List of Research Outputs

 

Zhou H., Shiu S.W.M., Wong Y. and Tan K.C.B., Association between advanced glycation end products and reduced activity of HDL to protect LDL against oxidation in type 2 diabetes mellitus, American Diabetes Association 66th Scientific Sessions, Washington. 2006.

 

Zhou H., Tan K.C.B., Chow W.S., Bucala R. and Betteridge D.J., Association between advanced glycation end products and serum cholesterol efflux capacity in type 2 diabetes mellitus, The 6th International Diabetes Federation Western Pacific Region Congress, Bangkok, Oct 2005.

 

Zhou H., Shiu S.W.M., Wong Y. and Tan K.C.B., Decreased activity of HDL to protect LDL against oxidation in type 2 diabetic patients with nephropathy, 5th Congress of Asian Pacific Society of Atherosclerosis and Vascular Diseases. 2006.

 

Zhou H., Shiu S.W.M., Wong Y. and Tan K.C.B., HDL dysfunction in type 2 diabetic patients with nephropathy, International Symposium on Healthy Aging, Hong Kong. 2006.

 

Researcher : Zhu S



List of Research Outputs

 

Sun Y., Xia H.H.X., Zhu S., Zou B., Lin M.C., Kung H. and Wong B.C.Y., Novel interaction between xiap-associated factor 1 (XAF1) and nuclear coactivator CBP in colon cancer. Digestive Disease Week 2006, 20-25 May, Los Angeles, USA , Gastroenterology. 2006, 4 Suppl 2: A680.

 

Wang J., Peng Y., Sun Y., He H., Zhu S., An X.M., Li M., Lin M.C., Zou B., Xia H.H.X., Jiang B., Chan O.O., Yuen R.M.F., Kung H.F. and Wong B.C.Y., All-Trans Retinoic Acid Induces XAF1 Expression Through an Interferon Regulatory Factor-1 Element in Colon Cancer, Gastroenterology. 2006, 130(3): 747-758.

 

Researcher : Zhu W



List of Research Outputs

 

Wang Z., Lau G., Zhu W. and Chao C., Influence of test capacitor features on piezoelectric and dielectric measurement of ferroelectric films, IEEE Trans ultrason Ferroelectr Freq Control. 2006, 53(1): 15-22.

 

Researcher : Zou B



List of Research Outputs

 

He H., Xia H.H.X., Wang J., Gu Q., Lin M.C., Zou B., Lam S.K., Chan O.O., Yuen R.M.F., Kung H.F. and Wong B.C.Y., Inhibition of human telomerase reverse transcriptase by nonsteroidal antiinflammatory drugs in colon carcinoma, Cancer. 2006, 106(6): 1243-9.

 

Sun Y., Wang J., Xia H.H.X., Zou B., Lin M.C., Kung H. and Wong B.C.Y., Interferon-β-induced expression of XAF1 requires phosphorylation of STAT1 and a sequential activation of protein kinase C and JNK in colon cancer. Digestive Disease Week 2006, 20-25 May, Los Angeles, USA , Gastroenterology. 2006, 4 Suppl 2: A671.

 

Sun Y., Xia H.H.X., Zhu S., Zou B., Lin M.C., Kung H. and Wong B.C.Y., Novel interaction between xiap-associated factor 1 (XAF1) and nuclear coactivator CBP in colon cancer. Digestive Disease Week 2006, 20-25 May, Los Angeles, USA , Gastroenterology. 2006, 4 Suppl 2: A680.

 

Wang J., Peng Y., Sun Y., He H., Zhu S., An X.M., Li M., Lin M.C., Zou B., Xia H.H.X., Jiang B., Chan O.O., Yuen R.M.F., Kung H.F. and Wong B.C.Y., All-Trans Retinoic Acid Induces XAF1 Expression Through an Interferon Regulatory Factor-1 Element in Colon Cancer, Gastroenterology. 2006, 130(3): 747-758.

 

Wang J., He H., Yu L., Xia H.H.X., Lin M.C., Gu Q., Li M., Zou B., An X.M., Jiang B., Kung H.F. and Wong B.C.Y., HSF1 down-regulates XAF1 through transcriptional regulation, Journal of Biological Chemistry. 2006, 281(5): 2451-2459.

 

Xia H.H.X., He H., Wang J., Gu Q., Lin M.C., Zou B., Yu L., Sun Y., Chan O.O., Kung H.F. and Wong B.C.Y., Induction of apoptosis and cell cycle arrest by a specific c-Jun NH(2)-terminal kinase (JNK) inhibitor, SP-600125, in gastrointestinal cancers., Cancer Letters. 2005, 241(2): 268-74.

 

Yu L., Wang J., Zou B., Lin M.C., Wu Y.L. and Wong B.C.Y., Sulindac Metabolites Induces XAF1 Expression by Inhibition of Extracellular Signal-regulated Kinase 1/2 Phosphorylation in Human Gastric Cancer Cells. Oral presentation, Asian Pacific Digestive Week 2005, Sept. 25-28, 2005, Seoul, Korea , Journal of Gastroenterology and Hepatology. 2005, 20: Supp A299.

 

Yu L., Wang J., Zou B., Wu Y.L. and Wong B.C.Y., XAF1 mediates inhibition of extracellular signal-regulated kinase 1/2 induced apoptosis in human colon cancer cells. Digestive Disease Week 2006, 20-25 May, Los Angeles, USA , Gastroenterology. 2006, 4 Suppl 2: A531.

 

Zou B., Chim J.C.S., Lin M.C., Zeng H., He H., Yu L., Sun Y., Jiang S.H. and Wong B.C.Y., Correlation between the single-site CpG mutation within the gene promoter and the expression silencing of XIAP -Associated Factor 1 (XAF1) in human colon cancer cell lines. Asian Pacific Digestive Week, Sept. 25-28, 2005, Seoul, Korea., Journal of Gastroenterology and Hepatology. 2005, 20: Supp A253.

 

Zou B., Chim J.C.S., Lin M.C., Zeng H., He H., Yu L., Sun Y., Jiang S.H. and Wong B.C.Y., Distinguished Poster Award, "Correlation between the single-site CpG mutation within the gene promoter and the expression silencing of XIAP -Associated Factor 1 (XAF1) in human colon cancer cell lines" , Asian Pacific Digestive Week, Sept. 25-28, Seoul, Korea. 2005.

 

Zou B., Lin M.C., Lam S.K., Tu S., Zeng H., Yang Y., Wang J., He H., Jiang S.H., Kung H. and Wong B.C.Y., Distinguished Poster Award, "Hypermethylation status around exon 1 of XIAP-Associated Factor 1(XAF1) in human gastric and colon cancer cell line.", Asian Pacific Digestive Week, Sept. 25-28, Seoul, Korea.. 2005.

 

Zou B., Lin M.C., Lam S.K., Tu S., Zeng H., Yang Y., Wang J., He H., Jiang S.H., Kung H. and Wong B.C.Y., Hypermethylation status around exon 1 of XIAP-Associated Factor 1(XAF1) in human gastric and colon cancer cell line. Asian Pacific Digestive Week, Sept. 25-28, 2005, Seoul, Korea. , Journal of Gastroenterology and Hepatology. 2005, 20: Supp A370.



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