Dept of Surgery

DEPT OF SURGERY

Researcher : Au DKK

Project Title:	Electrical tinnitus suppression in hearing-impaired patients
Investigator(s):	Au DKK, Ho WK
Department:	Surgery
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Abstract:

To evaluate the effectiveness of electrical tinnitus suppression in patients with sensorineural hearing loss; to compare the effectiveness of high versus low electrical stimulation rate in tinnitus suppression.

List of Research Outputs

Au D.K.K., Lam B.C.C., Young B.W.Y., Yeung W. and Hui Y., AABR results on universal newborn hearing screening programme in Hong Kong, Poster Presentation, 4th Widex Congress of Paediatric Audiology, Canada. 2005.

Au D.K.K., Chairperson, Research Seminar V - Bilateral Implantation and Bimodal Fitting Symposium , "The 5th Asia Pacific Symposium on Cochlear Implant and Related Sciences 2005", CUHK. 2005.

Au D.K.K., Co-opt Member of Medical Committee (1998 - 2006), Occupational Deafness Compensation Board. 2006.

Au D.K.K., Hui Y., Hao J. and Wei W.I., Electrode Insertion Depth on Cantonese Tone Perception in Hong Kong Cochlear Implant Users, Proceedings, 5th Asia Pacific Symposium on Cochlear Implant and Related Sciences, Hong Kong. 2005, 97.

Au D.K.K., Fact and fallacy in neonatal screening, Proceedings, Advances in Deafness Management, Hong Kong. 2005, 19.

Au D.K.K., Honorary Audiologist (1998 - present), Queen Mary Hospital, HK. 2006.

Au D.K.K., Honorary Visiting Professor (2001 - present), Faculty of Medicine and Surgery, University of Santo Tomas, The Philippines. 2006.

Au D.K.K., Invited Lecturer, Development Issues in Children With and Without Disabilities, Department of Rehabilitation Sciences, Hong Kong Polytechnics University. 2005.

Au D.K.K., Invited Lecturer, Occupational Deafness, Department of Community and Family Medicine, CUHK. 2006.

Au D.K.K., Invited Lecturer, Vestibular Assessments, Department of Speech and Hearing Sciences, HKU. 2005.

Au D.K.K., Invited Panellist, Bone-anchored Hearing Aid, Symposium on "The 5th Asia Pacific Symposium on Cochlear Implant and Related Sciences 2005", Cochlear (HK) Limited. 2005.

Au D.K.K., Invited Speaker, Bimodal Hearing Fitting, Audiological Services Unit, Education & Manpower Bureau, HK. 2005.

Au D.K.K., Invited Speaker, Post Hearing Aid Fitting Care, Occupational Deafness Compensation Board. 2006.

Au D.K.K., Member of Medical Committee (2006 - present), Occupational Deafness Compensation Board. 2006.

Au D.K.K., Newspaper Interview, Noise-induced hearing loss, Hong Kong Economic Times. 2006.

Au D.K.K., Newspaper Interview, Non-organic hearing loss, Sing Pao. 2006.

Au D.K.K., Newspaper Interview, Vertigo and Imbalance, Hong Kong Economic Times. 2006.

Au D.K.K., Radio Program, Occupational Deafness Compensation, Channel 1, Radio Television Hong Kong. 2005.

Au D.K.K., Radio Program, Vertigo and Dizziness, Channel 1, Radio Television Hong Kong. 2006.

Au D.K.K., Representative of the University of Hong Kong in the Unviersitas 21, Health Sciences Group Annual Meeting, University of Lund, Sweden. 2006.

Au D.K.K., Reviewer , Ear and Hearing Journal . 2006.

Au D.K.K., Speaker & Instructor, Practical Otology for General Practitioners a. Principles of audiology and vestibular assessment b. Practicum on vestibular assessment, Divsion of ORL-HN, Department of Surgery, HKU & Institute of Health Care, Hospital Authority. 2005.

Au D.K.K., Speaker at Press Conference, The First Hospital-Based Universal Newborn Hearing Screening Programme in HK - AABR Test Effectively Identifies Hearing Impaired Infants, Queen Mary Hospital, Pamela Youde Nethersole Eastern Hospital. 2005.

Au D.K.K., TV Program, Road to Health, Noise-induced Hearing loss from Entertainment Noise, , Radio Television Hong Kong. 2006.

Au D.K.K., TV Program, Vestibular Assessment, Road to Health, Radio Television Hong Kong. 2006.

Au D.K.K., Vice-Chairman (Dec 2004 - present), Hong Kong Society for the Deaf . 2006.

Au D.K.K., Visiting Professor, Paediatric Audiology, Faculty of Medicine & Surgery, University of Santo Tomas. 2005.

Chu K.M.Y., Au D.K.K., Hui Y., Chow C.K. and Wei W.I., Short electrode insertion in cochlear implantation: speech perception performance of Cantonese-speaking subjects., Arta Otolaryngol. 2005, 125: 718-724.

Hui Y. and Au D.K.K., Revision cochlear implant, Proceedings, Advances in Deafness Management, Hong Kong. 2005, 55-56.

Hui Y., Au D.K.K. and Chow C.K., The use of BAHA for single sided deafness, Proceedings, Advances in Deafness Management, Hong Kong. 2005, 57-58.

Researcher : Cai Q

List of Research Outputs

Cai Q., Tian L., Chen Y., Chan V.S.F., Thompson P.W., Lamb J.R. and Tam P.K.H., The effect of PPAR-gamma agonist in HUVEC activation, 30th FEBS Congress & 9th IUBMB Conference, Budapest, Hungary, 2-7 July 2005.

Researcher : Cai W

List of Research Outputs

Garcia-Barcelo M.M., So M.T., Lau K.C., Leon Y.Y., Yuan Z., Cai W., Lui V.C.H., Fu M., Herbrick J.A., Gutter E., Proud V., Li L., Pierre-Louis J., Aleck K., van Heurn E., Belloni E., Scherer S.W. and Tam P.K.H., Population differences in the polyalanine domain and 6 new mutations in HLXB9 in patients with Currarino syndrome, Clinical Chemistry. 2006, 52(1): 46-52.

Researcher : Cai Z

List of Research Outputs

Cai Z., Chiu J. and He Q., Current Progresses in Sample Preparation for Two-Dimensional Electrophoresis in Proteomics, Current Proteomics. 2006, 2: 259-268.

Researcher : Chan HM

List of Research Outputs

Fan J.Q., Chen Y., Chan H.M., Tam P.K.H. and Ren Y., Removing intensity effects and identifying significant genes for Affymetrix arrays in macrophage migration inhibitory factor-suppressed neuroblastoma cells, Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2005, 102(49): 17751-17756.

Ren Y., Cao B., Law S.Y.K., Xie Y., Lee P.Y., Cheung C.M., Chen Y., Huang X., Chan H.M., Zhao P., Luk J.M.C., Vande Woude G. and Wong J., Hepatocyte growth factor promotes cancer cell migration and angiogenic factors expression: a prognostic marker of human esophageal squamous cell carcinomas, Clinical Cancer Research. 2005, 11(17): 6190-6197.

Ren Y., Chan H.M., Fan J., Xie Y., Chen Y., Li W., Jiang G., Liu Q., Meinhardt A. and Tam P.K.H., Inhibition of tumor growth and metastasis in vitro and in vivo by targeting macrophage migration inhibitory factor in human neuroblastoma, Oncogene. 2006, 25(25): 3501-3508.

Researcher : Chan HM

List of Research Outputs

Researcher : Chan KL

List of Research Outputs

Chan K.L., Tang M.H.Y., Tse H.Y., Tang R.Y.K. and Tam P.K.H., Meconium peritonitis: prenatal diagnosis, postnatal management and outcome, Prenatal Diagnosis. 2005, 25: 676-682.

Chan K.L., Hui W.C. and Tam P.K.H., Prospective, randomized, single-center, single-blind comparison of laparoscopic vs open repair of pediatric inguinal hernia, Surgical Endoscopy. 2005, 19: 927-932.

Chan K.L., Recurrences in children, 4th Suvretta Meeting 2006, 1-4 February 2006, Switzerland. 2006.

Leung K.Y., Chan K.L., Leung W.C., Lee C.P., Wong K.Y. and Tang M.H.Y., Endoscopic laser therapy for severe twin-twin transfusion syndrome: A case report, Journal of Paediatrics, Obstetrics and Gynaecology. 2005, Sep/Oct: 202-203.

Researcher : Chan MS

List of Research Outputs

Ho J.W.C., Wei R. and Chan M.S., Hereditary colorectal cancer syndromes in Hong Kong: a Registry's perspective, Hereditary Cancer in Clinical Practice. 2005, 3(4): 147-154.

Researcher : Chan PMP

List of Research Outputs

Chan P.M.P., Micrometastases of esophageal cancer, 2006.

Researcher : Chan SC

List of Research Outputs

Chan S.C., Associate Consultant, Queen Mary Hospital, Hospital Authority, Hong Kong. 2006.

Chan S.C., Donor perspective of right lobe adult-to-adult live donor liver transplantation, Master of Surgery thesis. 2005.

Chan S.C., Liu C.L., Lo C.M., Lam B.K.Y., Lee E.W.M., Wong Y. and Fan S.T., Estimating liver weight of adults by body weight and gender, World Journal of Gastroenterology. 2006, 12(14): 2217-2222.

Chan S.C., Lo C.M. and Fan S.T., Head-to-head comparison of the right and left liver graft in adult-to-adult live donor liver transplantation (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A199.

Chan S.C., Fan S.T., Lo C.M. and Liu C.L., Head-to-head comparison of the right and left liver graft in adult-to-adult live donor liver transplantation (Abstract), The 2006 Joint International Congress of the International Liver Transplantation Society (ILTS), the European Liver and Intestinal Transplant Association (ELITA), and the Liver Intensive Care Group of Europe (LICAGE), Milan, Italy, 3 - 6 May 2006. Liver Transplantation. 2006, 12: C34.

Chan S.C., Lo C.M., Wong Y., Liu C.L. and Fan S.T., Long-term biological consequences of donor right hepatectomy including the middle hepatic vein in adult-to-adult live donor liver transplantation, Liver Transplantation. 2006, 12(2): 259-263.

Chan S.C., Reviewer, Asian Journal of Surgery. 2006.

Chan S.C., Reviewer, Liver Transplantation. 2006.

Chan S.C. and Fan S.T., Right liver adult-to-adult live donor liver transplantation in Hong Kong, Transplantation Reviews. 2006, 20(1): 34-40.

Chan S.C., Fan S.T., Lo C.M. and Liu C.L., Side and size of grafts on surgical outcomes of adult-to-adult live donor liver transplantation (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Chan S.C., Lo C.M., Liu C.L., Wong Y. and Fan S.T., Versatility and viability of hepatic venoplasty in live donor liver transplantation using the right lobe with the middle hepatic vein, Hepatobiliary and Pancreatic Diseases International. 2005, 4(4): 618-621.

Fan S.T., Lo C.M., Liu C.L. and Chan S.C., First-class Award of the Chinese State Scientific and Technological Progress Award, 2005.

Fan S.T., Lo C.M., Liu C.L. and Chan S.C., Pre-transplant live liver donor evaluation and perioperative care. Protocol of Queen Mary Hospital, University of Hong Kong (Abstract), Vancouver Forum on the Medical Care of the Live Lung, Liver, Intestinal and Pancreas Donor, Vancouver, Canada, 14-16 September 2005.

Liu C.L., Fan S.T., Lo C.M., Wei W.I., Chan S.C., Yong B.H. and Wong J., Operative outcomes of adult-to-adult right lobe live donor liver transplantation: a comparative study with cadaveric whole-graft liver transplantation in a single center, Annals of Surgery. 2006, 243(3): 404-410.

Ng K.K.C., Lo C.M., Chan S.C. and Fan S.T., Increasing applicability of liver transplantation over 13 years - a single institution experience (Oral Presentation), The Annual Scientific Meeting of the Hong Kong Society of Transplantation, Hong Kong, 2 April 2006.

Tong D.K.H., Cheng C.W., Chan S.C., Wong L.N.J. and Chow L.W.C., Phase II study on an "all oral" regimen of capecitabine, idarubicin and cyclophosphamide in metastatic breast cancer: safety, efficacy and quality of life, Oncology. 2005, 68: 520-525.

Researcher : Chan SC

List of Research Outputs

Chan S.C., Associate Consultant, Queen Mary Hospital, Hospital Authority, Hong Kong. 2006.

Chan S.C., Donor perspective of right lobe adult-to-adult live donor liver transplantation, Master of Surgery thesis. 2005.

Chan S.C., Reviewer, Asian Journal of Surgery. 2006.

Chan S.C., Reviewer, Liver Transplantation. 2006.

Chan S.C. and Fan S.T., Right liver adult-to-adult live donor liver transplantation in Hong Kong, Transplantation Reviews. 2006, 20(1): 34-40.

Fan S.T., Lo C.M., Liu C.L. and Chan S.C., First-class Award of the Chinese State Scientific and Technological Progress Award, 2005.

Researcher : Chan VSF

List of Research Outputs

Cai Q., Tian L., Chen Y., Chan V.S.F., Thompson P.W., Lamb J.R. and Tam P.K.H., The effect of PPAR-gamma agonist in HUVEC activation, 30th FEBS Congress & 9th IUBMB Conference, Budapest, Hungary, 2-7 July 2005.

Chan V.S.F., Chan Y.K., Chen Y., Poon L.L.M., Cheung A.N.Y., Zheng B., Chan K.H., Mak W.W., Ngan H.Y.S., Xu X., Screaton G., Tam P.K.H., Austyn J.M., Chan L.C., Yip S.P., Peiris J.S.M., Khoo U.S. and Lin C.L., Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection. , Nature Genetics. 2006, 38: 38-46.

Khoo U.S., Chan V.S.F., Chan Y.K., Chen Y., Poon L.L.M., Cheung A.N.Y., Zheng B., Ngan H.Y.S., Tam P.K.H., Chan L.C., Yip S.P., Peiris J.S.M., Sham P.C. and Lin C.L., The protective role of homozygous L-SIGN (CLEC4M) in SARS coronavirus infection., HUGO's 11th Human Genome Meeting, Helsinki, Finland. . 2006.

Researcher : Chan VWM

List of Research Outputs

Lee P.Y., Tong M.K., Leung P.L., Chan V.W.M., Leung S.Y.L., Tam P.C., Chan K.W., Lee C.K.F., Yeung W.S.B. and Luk J.M.C., Kidney claudin-19: Localization in distal tubules and collecting ducts and dysregulation in polycystic renal disease, FEBS Letters. 2006, 580(3): 923-31.

Researcher : Chau KL

List of Research Outputs

Ting J.Y., Lam B.C.C., Ngai C.S.W., Leung W.C. and Chau K.L., Splenic rupture in a premature neonate, Hong Kong Medical Journal. 2006, 12(1): 68-70.

Researcher : Chen BLS

List of Research Outputs

Lui V.C.H., Leon Y.Y., Garcia-Barcelo M.M., Ganster R.W., Chen B.L.S., Hutson J.M. and Tam P.K.H., Novel RET mutation produces a truncated RET receptor lacking the intracellular signaling domain in a 3-generation family with Hirschsprung Disease, Clinical Chemistry. 2005, 51(8): 1552-1554.

Researcher : Chen L

List of Research Outputs

Luk J.M.C., Chen L., Lam B.K.Y., Ho D.W.Y., Peng J.R., Leng X.S., Hui C.K., Lau G., Yip T.T. and Fan S.T., Comparing serum alpha-fetoprotein level and SELDI-TOF-MS profiling for diagnosis of hepatocellular carcinoma (Abstract), The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2-3 December 2005.

Researcher : Chen Y

List of Research Outputs

Cai Q., Tian L., Chen Y., Chan V.S.F., Thompson P.W., Lamb J.R. and Tam P.K.H., The effect of PPAR-gamma agonist in HUVEC activation, 30th FEBS Congress & 9th IUBMB Conference, Budapest, Hungary, 2-7 July 2005.

Chan V.S.F., Chan Y.K., Chen Y., Poon L.L.M., Cheung A.N.Y., Zheng B., Chan K.H., Mak W.W., Ngan H.Y.S., Xu X., Screaton G., Tam P.K.H., Austyn J.M., Chan L.C., Yip S.P., Peiris J.S.M., Khoo U.S. and Lin C.L., Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection. , Nature Genetics. 2006, 38: 38-46.

Fan J.Q., Chen Y., Chan H.M., Tam P.K.H. and Ren Y., Removing intensity effects and identifying significant genes for Affymetrix arrays in macrophage migration inhibitory factor-suppressed neuroblastoma cells, Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2005, 102(49): 17751-17756.

Khoo U.S., Chan V.S.F., Chan Y.K., Chen Y., Poon L.L.M., Cheung A.N.Y., Zheng B., Ngan H.Y.S., Tam P.K.H., Chan L.C., Yip S.P., Peiris J.S.M., Sham P.C. and Lin C.L., The protective role of homozygous L-SIGN (CLEC4M) in SARS coronavirus infection., HUGO's 11th Human Genome Meeting, Helsinki, Finland. . 2006.

Liu Y., Poon R.T.P., Li L., Qian X., Chen Y., Xu Y., Sun H.C., Tang Z.Y. and Fan S.T., Synergistic inhibitory effects of PTK787/ZK222584 and interferon-alfa on hepatocellular carcinoma with metastatic potential (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A94.

Lui V.C.H., Cheng W.C., Chen Y., Sham M.H. and Tam P.K.H., Homeobox gene HOXB5 is required in the embryonic development of the enteric nervous system, 52nd Annual International Congress of British Association of Paediatric Surgeons, Dublin, Ireland, 12-15 July 2005.

Lui V.C.H., Cheng W.C., Chen Y., Sham M.H. and Tam P.K.H., Perturbation of Hoxb5 signalling in vagal neural crest cells causes defective development of the enteric nervous system, 15th International Society of Developmental Biologists Congress 2005, Sydney, Australia, 3-7 September 2005.

Ren Y., Cao B., Law S.Y.K., Xie Y., Lee P.Y., Cheung C.M., Chen Y., Huang X., Chan H.M., Zhao P., Luk J.M.C., Vande Woude G. and Wong J., Hepatocyte growth factor promotes cancer cell migration and angiogenic factors expression: a prognostic marker of human esophageal squamous cell carcinomas, Clinical Cancer Research. 2005, 11(17): 6190-6197.

Ren Y., Chan H.M., Fan J., Xie Y., Chen Y., Li W., Jiang G., Liu Q., Meinhardt A. and Tam P.K.H., Inhibition of tumor growth and metastasis in vitro and in vivo by targeting macrophage migration inhibitory factor in human neuroblastoma, Oncogene. 2006, 25(25): 3501-3508.

Researcher : Chen Y

List of Research Outputs

Researcher : Chen Y

Project Title:	TGF-beta signaling in rat gut ischemia reperfusion injury
Investigator(s):	Chen Y, Lui VCH, Tam PKH
Department:	Surgery
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2006
Completion Date:	01/2007

Abstract:

Gut ischemia reperfusion: The gut mucosa serves as the first line of both nutrition absorption and innate defense. Disruption of blood supply causes damages to the gut mucosa and its underlining tissues in surgical procedures such as abdominal aortic aneurysm surgery, cardiopulmonary bypass, and intestinal transplantation, or in pathological conditions such as strangulated hernias and neonatal necrotizing enterocolitis. Ischemic conditions due to interrupted blood supply result in hypoxic injury to the gut. Paradoxically, restoration of blood flow in reperfusion of the ischemic gut may lead to further tissue damage (reperfusion injury). Gut ischemia reperfusion injury (IRI) is not only restricted to local sites, but also can lead to remote organ damage or systematic inflammation such as sepsis or multi organ failure (MOF). Although IRI injury occurs in only a small proportion (1-2%) of gastrointestinal diseases, the mortality from IRI-associated complications is alarmingly high (60-80%). The disease therefore warrants further study. Pathological changes associated with gut IRI involve an increase of gut permeability, shortening of villi, bleeding, and bacteria translocation. Shortening of villi is accompanied by the sloughing of enterocytes and loss of globlet cells which exposes the underlining blood capillary of the villi to gut bacteria and greatly increases the risk of sepsis development. The mechanisms involved in this phenomenon have not yet been determined, but reactive oxygen spices (ROS) formation and release during reperfusion may be an important factor. Pro-inflammatory cytokines such as IL-1 and TNF-alpha also contribute to the gut IRI process. Intestinal macrophages - resident macrophages (rMphi): Inflammatory cells such as mast cells, polymorphonuclear neutrophils (PMN) and platelets have been implicated in gut IRI. Recently, gut rMphi have also been shown to be important in gut IRI injury. The gut is one of the biggest reservoirs of macrophages in the body and the mucosa lining is the largest body surface linked to the external environment. The symbiosis of the gut bacteria within the gut is maintained by the innate immune system which is composed mainly of rMphi. They are derived from blood monocytes after infiltration into the gut and display a characteristic phenotype in that they do not express many innate receptors including the receptor to bacteria LPS (CD14) but possess phagocytic and bacteriocidal activity. Their restricted reactivity to bacteria limits mucosa inflammatory responses in normal intestinal mucosa. The lack of responsiveness of rMphi is mainly mediated by the regulation of TGF-beta signaling. It is not known if stimuli such as hypoxia or stress which affect local TGF-beta production may reverse this unresponsiveness and activate rMphi, with consequent tissue damage. TGF-beta signaling: Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine involved in the regulation of proliferation, differentiation, migration, and survival of many different cell types. Three TGF-beta isoforms have been identified in mammals, TGF-beta1, 2 and 3, some of whose functions overlap. TGF-beta is secreted in a latent form, which requires activation by proteases or thrombospondin before it can bind to its specific receptors. Seven type I and five type II serine/threonine kinase receptors, also termed as Activin-receptor-like kinases (ALKs), have been identified for TGF-betas in vertebrates. After ligand binding and activation of type I receptors, signals are then transduced from the membrane to the nucleus via intracellular effectors, termed Smads (include receptor regulated Smads: Smad 1, 3, 5 and 8; Smad 4 and inhibitory Smads: Smad 6 and 7). The complexity of TGF-beta signaling is signified by differential cellular responses dependent on different cell-types and TGF-beta concentrations. In addition, cellular responses of TGF-beta also depend on other signal transduction pathways, which can either synergize or antagonize the TGF-beta signal. In line with the complexity of TGF-beta signaling, macrophages can be activated or de-activated by TGF-beta. For instance, TGF-beta deactivates sodium caseinate activated peritoneal rMphi and reduces the release of H2O2. However, the roles of TGF-beta in the activation and/or deactivation of gut rMphi and the maintenance of the unresponsive state of gut rMphi in IRI have not been investigated. Purpose: To investigate the role of TGF-beta signaling pathway in gut ischemia reperfusion injury (IRI) Work done by the PI: Our published work has shown that gut rMphi play an important role in the initiation of IRI. Pathological changes characteristic of IRI were evident in the gut well before the infiltration of PMN. In addition, depletion of rMphi by intraperitoneal injection of chlodronateliposome greatly reduced gut IRI. Preliminary data Typical progress of gut enterocytes sloughing was observed in our gut IRI model. To investigate the involvement of TGF-beta in gut IRI, rats were treated with anti-TGF-beta antibody before IR challenge. Isotype antibody injection rats were used as controls. The preliminary data showed that anti-TGF-beta antibody treated rats displayed severe enterocytes sloughing and marked villi blunting and shortening. In contrast, only mild damage in the isotype injection controls was observed. The degree of villi sloughing in the isotype control was much less than in the anti-TGF-beta treatment group (12% ±7% versus 45.5%±7% n=2 in each group).

List of Research Outputs

Researcher : Chen Y

List of Research Outputs

Researcher : Cheng LC

List of Research Outputs

Au W.Y., Pang A.W.K., Wan T.S.K., Ma E.S.K., Cheng L.C. and Kwong Y.L., Concomitant post-transplantation lymphoproliferative disease and therapy-related myelodysplastic syndrome after lung transplantation , The Journal of Heart and Lung Transplantation . 2006, 25(2): 259-260.

Researcher : Cheng Q

List of Research Outputs

Man K., Lo C.M., Xiao J.W., Ng T.P., Ng I.O.L., Sun K.W., Cheng Q. and Fan S.T., The significance of graft size on tumor recurrence/metastases after liver transplantation – Activation of cell invasion and migration pathways (Abstract), The 2006 Joint International Congress of the International Liver Transplantation Society (ILTS), the European Liver and Intestinal Transplant Association (ELITA), and the Liver Intensive Care Group of Europe (LICAGE), Milan, Italy, 3 - 6 May 2006. Liver Transplantation. 2006, 12: C30.

Researcher : Cheng SWK

Project Title:	Molecular profiling of cellular receptors and their specific ligands in abdominal aortic aneurysms and in relation to pathogenesis
Investigator(s):	Cheng SWK, Cheuk LY
Department:	Surgery
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003
Completion Date:	10/2005

Abstract:

To investigate the molecular change of a series of cellular receptors and their specific ligands in aneurysmal VSMCs, and study the mechanisms underlining the altered expression pattern.

Project Title:	Endovascular program for treating thoracic aortic dissections
Investigator(s):	Cheng SWK, Ting ACW
Department:	Surgery
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	04/2004

Abstract:

To initiate medical services for the poor and sick in the field of endovascular treatment of aortic dissections and provide equipment for such services.

Project Title:	Study of the pathological significance of COX-2 in vascular infection: implication of the therapeutic value of COX-2 inhibitor in Abdominal Aortic Aneurysm (AAA)
Investigator(s):	Cheng SWK, Cheuk LY
Department:	Surgery
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2005
Completion Date:	12/2006

Abstract:

The main objectives of this project are: 1) To test the hypothesis that vascular infection may induce vascular cell loss, which is dependent on the inflammatory COX-2 gene expression; 2) To determine whether COX-2 inhibitor has potential therapeutic value as an anti-apototic agent.

List of Research Outputs

Cheng S.W.K., AAA PTFE-cover stent (HK experience), The 2nd Taiwan Transcatheter Therapeutics (TTT) Live Course, Taiwan Society of Cardiovascular Interventions, Taipei, Taiwan, 4 December 2005. 2005.

Cheng S.W.K., Aortic aneurysms and peripheral vascular disease, Care for your Heart Association, Hong Kong, 30 July 2005. 2005.

Cheng S.W.K., Carotid stenosis in Asians: incidence and disease progression, The 6th Asian Chapter Congress of the International Union of Angiology, Bangkok, Thailand, 18-20 November 2005. 2005.

Cheng S.W.K., Chairman, Session on "Management of Complicated Hepatic Conditions", Hong Kong Surgical Forum, Hong Kong,13-14 January 2006. 2006.

Cheng S.W.K., Chairman, Session on Residents' research paper presentation, Hong Kong Surgical Forum, Hong Kong, 8-9 July 2005. 2005.

Cheng S.W.K., Charing Cross 28th International Symposium, London, UK, 8-11 April 2006. 2006.

Cheng S.W.K., Current status of endovascular aortic repair (EVAR), Annual Scientific Symposium, Cardiac Catherization & Intervention Centre, Hong Kong Sanatorium & Hospital, Hong Kong, 19 June 2006. 2006.

Cheng S.W.K., Development of endovascular stent grafts in treating aortic aneurysms, The 35th Annual Convention & Scientific Meeting of the Taiwan Society of Cardiology, Taipei, Taiwan, 20-21 August 2005. 2005.

Cheng S.W.K., EVAR for abdominal aortic aneurysm in Chinese patients, Tung Wah Group of Hospitals (TWGHs) Vascular Symposium, Department of Surgery, Kwong Wah Hospital, Hospital Authority, 6 January 2006. 2006.

Cheng S.W.K., EVAR for thoracic pathologies, Lecture organized by Cook at The American Club, Hong Kong, 29 November 2005. 2005.

Cheng S.W.K., Editor (2002 - present), Annals of the College of Surgeons of Hong Kong. 2006.

Cheng S.W.K., Editor-in-Chief (2003 - present), Asian Journal of Surgery. 2006.

Cheng S.W.K., Endovascular stent graft for aortic disease, Asian Cardiovascular & Thoracic Annals. 2006, 14(2): 91-92.

Cheng S.W.K., Endovascular stent grafts in treating aortic diseases: new initiatives, The 14th Annual Meeting of the Asian Society for Cardiovascular Surgery, Osaka, Japan, 1-3 June 2006. 2006.

Cheng S.W.K., Inivted live case demonstration: Zenith graft endovascular AAA repair, Chang Gung Memorial Hospital, Taipei, Taiwan, 21 August 2005. 2005.

Cheng S.W.K., Management of vascular complications vertebral artery and thoracolumbar big vessels, Combined Hong Kong-Taiwan AO Advance Spine Course Course, Department of Orthopaedics Surgery, Faculty of Medicine, The University of Hong Kong, Hong Kong, 21-23 September 2005. 2005.

Cheng S.W.K., Member (1996 - present), Editorial Board, Chinese Journal of Vascular Surgery. 2006.

Cheng S.W.K., Member (2002 - present), Editorial Board, Cutting Edge, College of Surgeons of Hong Kong Newsletter. 2006.

Cheng S.W.K., Membership Selection Committee Meeting for Fellowship of the American College of Surgeons, Beijing, China, 17 July 2005. 2005.

Cheng S.W.K., New treatment initiatives for aortic aneurysms and dissections: what we know and what we don't, The 6th Asian Chapter Congress of the International Union of Angiology, Bangkok, Thailand, 18-20 November 2005. 2005.

Cheng S.W.K., Reduction in deep vein reflux after concomitant subfacial endoscopic perforating vein surgery and superfical vein ablation in advanced primary chronic venous insufficiency, The 6th International Congress on Vascular & Endovascular Surgery and The 5th Congress on Budd-Chiari Syndrome, Jinan, China, 21-24 September 2005. 2005.

Cheng S.W.K., Serena Yang Professor in Vascular Surgery (April 2005 - present), Endowed Professorship, The University of Hong Kong. 2006.

Cheng S.W.K., The development of endovascular aortic stent grafts: Hong Kong experience, The 6th Asian Chapter Congress of the International Union of Angiology, Bangkok, Thailand, 18-20 November 2005. 2005.

Cheng S.W.K., The role of endovascular treatment of critical limb ischemia, The XXII World Congress of the International Union of Angiology, Lisbon, Portugal, 24-28 June 2006. 2006.

Cheng S.W.K., The training of a surgeon: an international perspective (An Asian Example), The 91st Annual Clinical Congress of the American College of Surgeons, San Francisco, USA, 16-20 October 2005. 2005.

Cheuk L.Y. and Cheng S.W.K., Differential expression of PGE2, Thromboxane A2 and Interleukin - 6 in intact and ruptured abdominal aortic aneurysms, The XIVth International Vascular Biology Meeting, Norrdwijkerhour, The Netherlands, 6-10 June 2006.

Cheuk L.Y., Cheung G.C.Y., Lau S.S.F. and Cheng S.W.K., Plasma fibrinogen level: an independent risk factor for long-term survival in Chinese patients with peripheral artery disease?, World Journal of Surgery. 2005, 29: 1263-1267.

Ho P., Cheng S.W.K., Ting A.C.W. and Poon J.T.C., Improvement of mortality of ruptured abdominal aortic aneurysm patients over 12 years and its relationship with tracheostomy, Annals of Vascular Surgery. 2006, 20(2): 175-182.

Ho P., Yiu W.K., Cheung G.C.Y., Cheng S.W.K., Ting A.C.W. and Poon J.T.C., Systemic review of clinical trials comparing open and endovascular treatment of abdominal aortic aneurysm, Surgical Practice. 2006, 10: 24-37.

Ting A.C.W., Cheng S.W.K., Ho P., Poon J.T.C., Wong Wu L.H. and Cheung G.C.Y., Reduction in deep vein reflux after concomitant subfascial endoscopic perforating vein surgery and superficial vein ablation in advanced primary chronic venous insufficiency, Journal of Vascular Surgery. 2006, 43(3): 546-550.

Researcher : Cheng WC

List of Research Outputs

Lui V.C.H., Cheng W.C., Chen Y., Sham M.H. and Tam P.K.H., Homeobox gene HOXB5 is required in the embryonic development of the enteric nervous system, 52nd Annual International Congress of British Association of Paediatric Surgeons, Dublin, Ireland, 12-15 July 2005.

Lui V.C.H., Cheng W.C., Chen Y., Sham M.H. and Tam P.K.H., Perturbation of Hoxb5 signalling in vagal neural crest cells causes defective development of the enteric nervous system, 15th International Society of Developmental Biologists Congress 2005, Sydney, Australia, 3-7 September 2005.

Researcher : Cheuk LY

Project Title:	*Detection of C. pneumoniae* by polymerase chain reaction-enzyme immunoassay (PCR-EIA) in abdominal aortic aneurysm walls and its association with rupture**
Investigator(s):	Cheuk LY, Cheng SWK, Ting ACW
Department:	Surgery
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004
Completion Date:	04/2006

Abstract:

To elucidate the possible molecular association between the endovascular presence of C. pneumoniae DNA in aneurysmal lesions and its significance in ruptured Abdominal Aortic Aneurysms.

List of Research Outputs

Cheuk L.Y. and Cheng S.W.K., Differential expression of PGE2, Thromboxane A2 and Interleukin - 6 in intact and ruptured abdominal aortic aneurysms, The XIVth International Vascular Biology Meeting, Norrdwijkerhour, The Netherlands, 6-10 June 2006.

Cheuk L.Y., Cheung G.C.Y., Lau S.S.F. and Cheng S.W.K., Plasma fibrinogen level: an independent risk factor for long-term survival in Chinese patients with peripheral artery disease?, World Journal of Surgery. 2005, 29: 1263-1267.

Researcher : Cheung CKY

List of Research Outputs

Lo C.M., Cheung C.K.Y., Lau G., Yuen R.M.F., Liu C.L., Chan S.H.C., Fan S.T. and Wong J., Significance of hepatitis B virus genotype in liver transplantation for chronic hepatitis B, American Journal of Transplantation. Blackwell, 2005, 5: 1893-900.

Luo Y., Lo C.M. and Cheung C.K.Y., Cross-sectional study on hepatitis B virus-specific CD4+ T cell immune response after liver transplantation (Abstract), The 2006 Joint International Congress of the International Liver Transplantation Society (ILTS), the European Liver and Intestinal Transplant Association (ELITA), and the Liver Intensive Care Group of Europe (LICAGE), Milan, Italy, 3 - 6 May 2006. Liver Transplantation. 2006, 12: C101.

Researcher : Cheung CM

List of Research Outputs

Ren Y., Cao B., Law S.Y.K., Xie Y., Lee P.Y., Cheung C.M., Chen Y., Huang X., Chan H.M., Zhao P., Luk J.M.C., Vande Woude G. and Wong J., Hepatocyte growth factor promotes cancer cell migration and angiogenic factors expression: a prognostic marker of human esophageal squamous cell carcinomas, Clinical Cancer Research. 2005, 11(17): 6190-6197.

Researcher : Cheung MNB

List of Research Outputs

Loo T.Y., Fong J.H.M., Cheung M.N.B. and Chow L.W.C., The efficacy of Paclitaxel on solid tumour analysed by ATP bioluminescence assay and VEGF expression: a translational research study, Biomedicine & Pharmacotherapy. 2005, 59: S337-S339.

Loo T.Y., Fong J.H.M., Zhu L., Cheung M.N.B. and Chow L.W.C., The value of bone marrow aspirates culture for the detection of bone marrow micrometastasis in breast cancer, Biomedicine & Pharmacotherapy. 2005, 59: S384-S386.

Lui E.L.H., Loo T.Y., Zhu L., Cheung M.N.B. and Chow L.W.C., DNA hypermethylation of TIMP3 gene in invasive breast ductal carcinoma, Biomedicine & Pharmacotherapy. 2005, 59: S363-S365.

Researcher : Cheung PSY

List of Research Outputs

Epstein R., Leung T.W.T. and Cheung P.S.Y., Panmucositis and chemosensitisation associated with betel quid chewing during dose-dense adjuvant breast cancer chemotherapy. Epub 2006 Mar 11. , Cancer Chemother Pharmacol. 2006, 58(6): 835-7.

Epstein R., Leung T.W.T., Mak J. and Cheung P.S.Y., Utility of a web-based breast cancer predictive algorithm for adjuvant chemotherapeutic decision making in a multidisciplinary oncology center. , Cancer Investigation. Taylor & Francis, 2006, 24(4): 367-373.

Researcher : Cheung ST

Project Title:	Characterization of the granulin/epithelin precursor gene in liver cancer
Investigator(s):	Cheung ST, Fan ST, Ng IOL
Department:	Surgery
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2003

Abstract:

To characterize the role of the granulin/epithelin precursor (GEP) gene in the development and progression of liver cancer: 1) to examine the abnormalities of the GEP gene in normal, diseased and tumor specimens of the liver; 2) to understand the clinical and pathological significance of the GEP gene: to study the growth and proliferation function of the GEP gene in liver cancer; to identify the GEP regulated genes/pathways in liver cancer.

Project Title:	Characterization of the granulin/epithelin precursor gene in liver cancer
Investigator(s):	Cheung ST, Fan ST, Ng IOL
Department:	Surgery
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	09/2003

Abstract:

N/A

Project Title:	Molecular target for liver cancer therapy
Investigator(s):	Cheung ST, Ho Jenny, Fan ST
Department:	Surgery
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2005
Completion Date:	01/2006

Abstract:

To study if GEP antibody has neutralizing function to inhibit cell proliferation, invasion and metastasis of liver cancer cells in vitro and in vivo.

Project Title:	Functional role of DNALI1 in liver cancer
Investigator(s):	Cheung ST, Ip YC, Fan ST
Department:	Surgery
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2006

Abstract:

Background: Dynein, axonemal, light intermediate polypeptide 1 (DNALI1) is the human homolog of the Chlamydomonas inner dynein arm gene, p28. The precise function of this gene is not known, however, it is a potential candidate for immotile cilia syndrome (ICS). Ultrastructural defects of the inner dynein arms are seen in patients with ICS. Immotile mutant strains of Chlamydomonas, a biflagellated algae, exhibit similar defects (SOURCE, provided by Genetics Department, Stanford University at http://smd.stanford.edu/cgi-bin/source/sourceSearch). Thus, DNALI1 is a motor protein that may regulate cell migration and motility. DNALI1 expression level was found to significantly associate with disease recurrence (hazard ratio 1.7, P=0.014) from our earlier genome-wide expression study by cDNA microarray approach on hepatocellular carcinoma (Mol Biol Cell 2002). To consolidate the prognostic significance of DNALI1 expression, we have examined the second sample set (n=50) and employed quantitative RT-PCR as an independent research method to measure the transcript level in comparison to microarray quantitation with the aim to determine the DNALI1 level. The association of a higher DNALI1 expression level with early disease recurrence was again confirmed (P=0.045). From the sequence database (Ensembl at http://www.ensembl.org/), DNALI1 revealed a polymorphism at nucleotide 194 (codon 65), which either harbored the C-allele (GCA, alanine) or T-allele (GTA, valine). We then further examined this gene polymorphism in liver cancer patients and healthy individuals. The T-allele was under-represented in liver cancer patients, and the tumor DNALI1 transcript level was significantly higher in patients with T-allele compared to patients with C-allele (unpublished data). Preliminary study: We have cloned the full-length cDNA of the DNALI1 C-allele into an expression vector pcDNA3.1 (Invitrogen, Carlsbad, CA, USA). Hepatoma cells HepG2 was transfected with DNALI1/pcDNA3.1 and empty vector, and selected under G418 for stable transfectants. Migration ability of the cells were detemined with the plain uncoated migration chamber (BD Biosciences, Bedford, MA, USA). DNALI1 transfectants (HepG2 with DNALI1 expression vector) revealed enhanced migration ability compared to the control transfectants (HepG2 with empty vector). Furthermore, DNALI1 transfectants were able to form xenografts in athymic nude mice, while control transfectants were not able to form tumors in athymic nude mice which was expected as parental HepG2 was non-tumorigenic as reported in the literatures. Thus, cells with enhanced DNALI1 expression demonstrated increased migration ability in vitro and tumorigenicity in vivo. Objectives of the present proposal: Expression of the DNALI1 C-allele transcript conferred the hepatoma cells HepG2 with enhanced migration ability in vitro and tumorigenicity in vivo from our pilot study. We therefore propose further functional studies to examine the biological roles of DNALI1. The full-length DNALI1 T-allele transcript will also be cloned into the expression vector, to compare with the DNALI1 C-allele data. Hepatoma cells HepG2 and normal liver cells Hs 399.Li will be transfected with the DNALI1 constructs with C- and T-allele, and empty vector. Transfectants will be examined for cell proliferation, invasion, migration, adhesion, transformation ability, etc. Our proposed study will help to delineate the biological roles of DNALI1 in liver cancer. This may lead to a novel approach of targeted therapy for liver cancer.

List of Research Outputs

Cheung S.T., Distinguished Scientific Award (Bronze Prize) - "Preoperative blood test for prognosis of hepatocellular carcinoma", The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2 - 3 December 2005. 2005.

Cheung S.T., Wong S.Y., Lee Y.T. and Fan S.T., GEP upregulates wild-type p53 in hepatocellular carcinoma, Oncology Reports. 2006, 15(6): 1507-1511.

Cheung S.T., Wong S.Y. and Fan S.T., Granulin-epithelin precursor and p53 in hepatocellular carcinoma (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A82.

Cheung S.T., Member of Editorial Board (January 2006 - present), Chinese Journal of Medicine. 2006.

Cheung S.T., Oral Presentation Award and Registration Award - "Granulin-epithelin precursor and p53 in hepatocellular carcinoma", Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25 - 28 March 2006. 2006.

Cheung S.T., Liu C.L., Chow J.P.H., Ng I.O.L. and Fan S.T., Preoperative blood test for prognosis of hepatocellular carcinoma (Abstract), The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2-3 December 2005.

Cheung S.T., Liu C.L., Chow J.P.H., Lee Y.T., Ip Y.C., Ho J.C.Y. and Fan S.T., Preoperative plasma transcript AA454543 level is an independent prognostic factor for hepatocellular carcinoma after partial hepatectomy, The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Ho J.C.Y., Cheung S.T. and Fan S.T., Novel serological marker for hepatocellular carcinoma (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Ip Y.C., Cheung S.T. and Fan S.T., MT1-MMP in relation to metastasis of hepatocellular carcinoma (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Ip Y.C., Cheung S.T., Leung K.L. and Fan S.T., Mechanism of metastasis by membrane type 1-matrix metalloproteinase in hepatocellular carcinoma, World Journal of Gastroenterology. 2005, 11(40): 6269-6276.

Liu C.L., Fan S.T., Cheung S.T., Lo C.M., Ng I.O.L. and Wong J., Anterior approach versus conventional approach right hepatic resection for large hepatocellular carcinoma: a prospective randomised controlled study (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Patil M.A., Gutgemann I., Zhang J., Ho C., Cheung S.T., Ginzinger D., Li R., Dykema K.J., So S., Fan S.T., Kakar S., Furge K.A., Buttner R. and Chen X., Array-based comparative genomic hybridisation reveals recurrent chromosomal aberrations and Jab1 as a potential target for 8q gain in hepatocellular carcinoma, Carcinogenesis. 2005, 26(12): 2050-2057.

Patil M.A., Zhang J., Ho C., Cheung S.T., Fan S.T. and Chen X., Hedgehog signaling in human hepatocellular carcinoma, Cancer Biology and Therapy. 2006, 5(1): 111-117.

Researcher : Chiu SW

List of Research Outputs

Liu H., Jin M.W., Xiang J.Z., Huang Y., Chiu S.W., Lau C.P. and Li G.R., Effects of raloxifene on action potential, transient outward and ultra-rapid delayed rectifier potassium current in human atrial myocytes., Journal of Hong Kong College Cardiology/The 9th Institute of Cardiovascular Science and Medicine & the 5th Scientific Conference on Cardiovascular Science Across the Strait. 2005, 13:111-OP60.

Tian M., Dong M., Chiu S.W., Lau C.P. and Li G.R., Effects of the antifungal antibiotic clotrimazole on human cardiac repolarization potassium currents. , British Journal of Pharmacology. 2006, 147: 289-297.

Researcher : Choi KM

List of Research Outputs

Choi K.M. and Choi K.M., Tumour infiltrating lymphocytes (TILS) - a prognostic factor of gastric adenocarcinoma, 2005.

Researcher : Chow CK

List of Research Outputs

Chu K.M.Y., Au D.K.K., Hui Y., Chow C.K. and Wei W.I., Short electrode insertion in cochlear implantation: speech perception performance of Cantonese-speaking subjects., Arta Otolaryngol. 2005, 125: 718-724.

Researcher : Chow JPH

List of Research Outputs

Cheung S.T., Liu C.L., Chow J.P.H., Ng I.O.L. and Fan S.T., Preoperative blood test for prognosis of hepatocellular carcinoma (Abstract), The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2-3 December 2005.

Cheung S.T., Liu C.L., Chow J.P.H., Lee Y.T., Ip Y.C., Ho J.C.Y. and Fan S.T., Preoperative plasma transcript AA454543 level is an independent prognostic factor for hepatocellular carcinoma after partial hepatectomy, The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Researcher : Chow LWC

Project Title:	Chemosensitivity study using a breast cancer cell line
Investigator(s):	Chow LWC
Department:	Surgery
Source(s) of Funding:	Other Funding Scheme
Start Date:	05/1996

Abstract:

To test the effect of combination chemotherapy on cell growth in a breast cancer cell line.

Project Title:	Radioguided surgery and breast cancer management courses and seminars
Investigator(s):	Chow LWC, Kwong A.
Department:	Surgery
Source(s) of Funding:	Professional Services Development Assistance Scheme
Start Date:	03/2003
Completion Date:	01/2006

Abstract:

To host a series of workshops and seminars, once every three months for a period of two years, on the radio guided sentinel node biopsy procedure. Other breast cancer management information and techniques will also be presented.

Project Title:	Chemosensitivity testing service for selection of chemotherapy in breast cancer patients
Investigator(s):	Chow LWC, Loo TY
Department:	Surgery
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	10/2004
Completion Date:	12/2005

Abstract:

To establish the proposed chemosensitivity assay as a service and be done for patients requiring chemotherapy.

Project Title:	Profiling DNA alterations in breast cancer by comparative genomic hybridization
Investigator(s):	Chow LWC
Department:	Surgery
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2005
Completion Date:	12/2005

Abstract:

The main objectives of this project are to: (1) study the common DNA alterations in term of CGH patterns for local Chinese population and identified the clinically important CGH patterns in term of prognosis; (2) study CGH patterns important in tumour initiation, promotion and metastasis by comparing differences in CGH patterns for different histologic stages; (3) find out the DNA changes for those breast cancer patients with multi-drug resistance.

List of Research Outputs

Anderson B.O., Shyyan R., Eniu A., Smith R.A., Yip C.H., Bese N.S., Chow L.W.C., Masood S., Ramsey S.D. and Carlson R.W., Breast cancer in limited-resource countries: an overview of the Breast Health Clobal Initiative 2005 guidelines , Breast Journal. 2006, Suppl 1: S3-15.

Bando H., Chow L.W.C., Higashimoto M., Loo W.T., Nakanishi C., Takebayashi Y. and Toi M., Correlation between Cox-2 related gene expressions and response to preoperative chemotherapy with celecoxib in primary breast cancer, Biomedicine & Pharmacotherapy. 2005, 59: S317-S318.

Cheng C.K., Chow L.W.C., Loo T.Y., Chan T.K. and Chan V.N.Y., The cell cycle checkpoint gene Rad9 is a novel oncogene activated by 11q13 amplification and DNA methylation in breast cancer, Cancer Research. 2005, 65: 8646-8654.

Chow L.W.C., Zhu L., Loo T.Y. and Lui E.L.H., Aberrant methylation of cyclooxygenase-2 in breast cancer patients, Biomedicine & Pharmacotherapy. 2005, 59: S264-S267.

Chow L.W.C., Liu K.L., CHAN C.Y., Chan T.C., Ho P.K., Lee W.Y., Leung L.H., Sy W.M., Yeung C.C. and Yung K.M., Association between body mass index and risk of formation of breast cancer in Chinese women, Asian Journal of Surgery. 2005, 28(3): 179-184.

Chow L.W.C., Loo T.Y. and Toi M., Current directions for COX-2 inhibition in breast cancer, Biomedicine & Pharmacoltherapy. 2005, 59: S281-S284.

Chow L.W.C., Cheng C.W.L., Wong J.L.N. and Toi M., Serum lipid profiles in patients receiving endocrine treatment for breast cancer - the results from the Celecoxib Anti-Aromatase Neoadjuvant (CAAN) Trial, Biomedicine & Pharmacotherapy. 2005, 59: S302-S305.

Chow L.W.C., Loo T.Y., Wai C.C.Y., Lui E.L.H., Zhu L. and Toi M., Study of COX-2, Ki67 and p53 expression to predict effectiveness of 5-flurouracil, epirubicin and cyclophosphamide with celecoxib treatment in breast cancer patients, Biomedicine & Pharmacotherapy. 2005, 59: S298-S301.

Chow L.W.C., Lui K.L., Chan J.C., Chan T.C., Ho P.K., Lee W.Y., Leung L.H., Sy W.M., Yeung C.C. and Yung A.K., The association between body mass index and the risk of breast cancer in Chinese women, Asian Journal of Surgery. 2005, 28: 179-184.

Chow L.W.C. and Toi M., Translational research in oncology comes timely (Editorial), Biomedicine & Pharmacotherapy. 2005, 59: S263.

Loo T.Y., Fong J.H.M., Cheung M.N.B. and Chow L.W.C., The efficacy of Paclitaxel on solid tumour analysed by ATP bioluminescence assay and VEGF expression: a translational research study, Biomedicine & Pharmacotherapy. 2005, 59: S337-S339.

Loo T.Y., Fong J.H.M., Zhu L., Cheung M.N.B. and Chow L.W.C., The value of bone marrow aspirates culture for the detection of bone marrow micrometastasis in breast cancer, Biomedicine & Pharmacotherapy. 2005, 59: S384-S386.

Lui E.L.H., Loo T.Y., Zhu L., Cheung M.N.B. and Chow L.W.C., DNA hypermethylation of TIMP3 gene in invasive breast ductal carcinoma, Biomedicine & Pharmacotherapy. 2005, 59: S363-S365.

Toi M., Horiguchi K., Bando H., Saji S. and Chow L.W.C., Trastuzumab: updates and future issues, Cancer Chemotherapy and Pharmacology. 2005, 1-6.

Tong D.K.H., Cheng C.W., Chan S.C., Wong L.N.J. and Chow L.W.C., Phase II study on an "all oral" regimen of capecitabine, idarubicin and cyclophosphamide in metastatic breast cancer: safety, efficacy and quality of life, Oncology. 2005, 68: 520-525.

Yip Y.S. and Chow L.W.C., Clinical experience with decetaxel for chinese breast cancer patients: hematological toxicity profiles, Breast Cancer. 2006, 13: 192-196.

Zhu L., Loo T.Y. and Chow L.W.C., Circulating tumor cells in patients with breast cancer: possible predictor of mciro-metastasis in bone marrow but not in sentinel lymph nodes, Biomedicine & Pharmacotherapy. 2005, 59: S355-S358.

Zhu L., Loo T.Y. and Chow L.W.C., Cyclooxygenase-2: possible predictor related to micrometastasis in breast cancer patients (Abstract), Biomedicine & Pharmacotherapy. 2005, 59: S318.

Zhu L., Loo W.T., Cheng C.W. and Chow L.W.C., Possible predictive markers related to micro-metastasis in breast cancer patients, Onoclogy Reports. 2006, 15: 1217-1223.

Researcher : Chu ACY

List of Research Outputs

Lee K.W., Man K., Ho J.W.Y., Wang X., Poon R.T.P., Xu Y., Ng T.P., Chu A.C.Y., Sun K.W., Ng I.O.L., Sun H.C., Tang Z.Y., Xu R. and Fan S.T., FTY720: a promising agent for treatment of metastatic hepatocellular carcinoma, Clinical Cancer Research. 2005, 11(23): 8458-8466.

Wang Y., Luk J.M.C., Chu A.C.Y., Ikeda K., Man K., Kaneda K. and Fan S.T., TNP-470 blockage of VEGF synthesis is dependent on MAPK/COX-2 signaling pathway in PDGF-BB-activated hepatic stellate cells, Biochemical and Biophysical Research Communications. 2006, 341-(1): 239-244.

Researcher : Chu KM

Project Title:	Characterization of the effect of MAPK inhibitor PD98059 on RON-activated anti-apoptotic pathway in gastric cancer
Investigator(s):	Chu KM, Ko S
Department:	Surgery
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2005
Completion Date:	02/2006

Abstract:

The objective of this study is to investigate the effect of mitogen-activated protein kinase (MAPK) inhibitor PD98059 on RON-activated anti-apoptotic pathway in gastric cancer.

List of Research Outputs

Aggarwal A., Guo D.L., Hoshida Y., Yuen S.T., Chu K.M., So S., Boussioutas A., Chen X., Bowtell D., Aburatani H., Leung S.Y. and Tan P., Topological and functional discovery in a gene coexpression meta-network of gastric cancer, Cancer Research. 2006, 66(1): 232-41.

Au W.Y., Pang A.W.K., Chan C., Chu K.M., Shek T.W.H. and Kwong Y.L., Epstein-barr virus-related gastric adenocarcinoma: an early secondary cancer post hemopoietic stem cell transplantation, Gastroenterology. 2005, 129(6): 2058-63.

Chan F.S. and Chu K.M., Predictors for therapeutic endoscopy in patients with Mallory-Weiss syndrome, 20th World Congress of Digestive Surgery, Rome, Italy, 29 November - 1 December 2006.

Chan O.O., Chu K.M., Lam S.K., Cheung K.L., Law S.Y.K., Kwok K.F., Wong R.W.M., Yuen R.M.F. and Wong B.C.Y., Early prediction of tumor recurrence after curative resection of gastric carcinoma by measuring soluble E-cadherin, Cancer. 2005, 104(4): 740-6.

Chan O.O., Chu K.M., Leung S.Y., Huang C., Sun Y.W., Ko S., Yuen R.M.F., Xia H.H.X., Cho C.H., Hui W.M., Lam S.K., Rashid A. and Wong B.C.Y., Helicobacter pylori infection, interleukin 1 beta polymorphism and predisposition to gastric cancer through the CpG island methylation pathway, Presented at 11th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong, 14 January 2006.

Chan O.O., Chu K.M., Sun Y.W., Cheung H.K.L., Lam S.K., Yuen R.M.F., Hui W.M. and Wong B.C.Y., The association between interleukin 1 beta polymorphism and hypermethylation at tumor suppressor genes in gastric cancer. , Gastroenterology. 2005, 128 (Suppl 2): 1399-400.

Chan O.O., Chu K.M., Leung S.Y., Huang C., Sun Y., Ko S., Yuen R.M.F., Xia H.H.X., Cho C.H., Hui W.M., Lam S.K., Rashid A. and Wong B.C.Y., Helicobacter pylori Infection, Interleukin 1 Beta Polymorphism and Predisposition to Gastric Cancer Through the Cpg Island Methylation, Gastroenterology. 2006, 130 (4 Suppl 2): A-717.

Chen W.Y.W., Hu X., Liang A.C.T., Au W.Y., So J.C.C., Wong M.L.Y., Shen L., Tao Q., Chu K.M., Kwong Y.L., Liang R.H.S. and Srivastava G., High BCL6 expression predicts better prognosis, independent of BCL6 translocation status, translocation partner, or BCL6 deregulating mutations, in gastric lymphoma, Blood. 2006, 108(7): 2373-83.

Chu K.M., "Common gastrointestinal disorders in Hong Kong", Lecture for Master of Science in Nursing (Course Code 53070), (Subject SN581 " Primary Care Problems of Adults I"), The Hong Kong Polytechnic University, 3 November 2005, Hong Kong. 2005.

Chu K.M., "Gastric cancer", Preparatory Course for Exit Examination in General Surgery, The College of Surgeons of Hong Kong and Department of Surgery, The University of Hong Kong, 2 September 2005, Hong Kong. 2006.

Chu K.M., "Gastrointestinal diseases", Core Module 14 "Biological Basis of Common Health Problems", Master of Medical Science, The University of Hong Kong, 23 March 2006, Hong Kong. 2006.

Chu K.M., "Gastrointestinal stromal tumour", at the 10th Shanghai/Hong Kong Surgical Convention, 11 July 2005, Shanghai, China. 2006.

Chu K.M., "Laparoscopic gastrectomy", The Hong Kong Surgical Forum, 8-9 July 2005, Hong Kong. 2005.

Chu K.M., "Oesophageal and gastric cancers", Certificate Course on Cancer Nursing for Registered and Enrolled Nurses, The Hong Kong Anti-Cancer Society, 29 September 2005, Hong Kong. 2005.

Chu K.M., "Understanding the cancer of stomach and its treatment", Cancer Counselling and Support Service, Queen Mary Hospital, 13 October 2005, Hong Kong. 2005.

Chu K.M., "Upper GI Surgery", Post-registration Certificate Course in Peri-operative Nursing, Institute of Advanced Nursing Studies, Hospital Authority, 27 May 2006, Hong Kong. 2006.

Chu K.M., Chairman for the Session on "Gastrointestinal Cancer", at the Hong Kong Surgical Forum, 8-9 July 2005, Hong Kong. 2006.

Chu K.M., Chairperson for Plenary Session on "Surgical Excellence 1", at the Joint Meeting of the 30th Annual Scientific Meeting of the Royal College of Surgeons of Thailand and the 15th Asian Congress of Surgery, 20-23 July 2005, Pattaya, Thailand. 2006.

Chu K.M., Course Director, "Critical Appraisal Skills Workshop for Surgery", Hospital Authority commissioned training, 24-25 February 2006, Hong Kong. 2006.

Chu K.M., Course Director, "Research Paper Writing Workshop for Higher Surgical Trainees", Hospital Authority commissioned training, 10 February 2006, Hong Kong. 2006.

Chu K.M., Expert Panel in Surgery for HA's Complaint & Potential Medicolegal cases (July 2001 - present), Hspital Authority, Hong Kong. 2006.

Chu K.M., Expert Reviewer (July 2000 - present), UICC Fellowships Programme, International Union against Cancer (UICC), Geneva, Switzerland. 2006.

Chu K.M., Inived referee, Surgical Practice. 2005.

Chu K.M., Invited referee (1998, 1999, 2004, 2005), Journal of Gastroenteroloogy and Hepatology. 2005.

Chu K.M., Invited referee (reviewer) , Cancer Therapy. 2006.

Chu K.M., Invited referee (reviewer) , Endoscopy. 2005.

Chu K.M., Invited referee (reviewer) , Gastroenterology. 2005.

Chu K.M., Invited referee (reviewer) , Journal of Gastroenterology and Hepatology. 2006.

Chu K.M., Invited referee (reviewer) , World Journal of Surgery. 2005.

Chu K.M., Invited referee (reviewer), Digestive & Liver Disease. 2006.

Chu K.M., Invited referee (reviewer), Digestive Surgery. 2006.

Chu K.M., Invited referee (reviewer), Hong Kong Medical Journal. 2006.

Chu K.M., Invited referee (reviewer), The Journal of Pathology. 2006.

Chu K.M., Invited referee, Asian Journal of Surgery. 2005.

Chu K.M., Invited referee, Clinical Gastroenterology and Hepatology. 2005.

Chu K.M., Member (October 2002 - present), Research Support Unit, The College of Surgeons of Hong Kong, Hong Kong. 2006.

Chu K.M., Member of Editorial Board (2006), Chinese Journal of Medicine. 2006.

Chu K.M., Membership of Editorial Board, Annals of Cancer Research and Therapy (since 2000). 2006.

Chu K.M., Membership of Editorial Board, Asian Journal of Surgery (Associate Editor) (since 2005). 2006.

Chu K.M., Membership of Editorial Board, Cancer Therapy (since 2003). 2006.

Chu K.M., Membership of Editorial Board, Cutting Edge (The College of Surgeons of Hong Kong) (since 2005). 2006.

Hu X., Liang A.C.T., Chen W.Y.W., Tao Q., Wong M.L.Y., Shen L., Wong K.Y., Au W.Y., Cheung W.L., Chu K.M., Kwong Y.L., Liang R.H.S. and Srivastava G., CD44 expression is regulated by translocation and promoter hypermethylation in gastric lymphoma, Proceedings of the 12th Hong Kong International Cancer Congress and 2nd Annual Meeting of Centre for Cancer Research, Hong Kong SAR, China, December 2005.

Hu X., Liang A.C.T., Chen W.Y.W., Tao Q., Au W.Y., Wong M.L.Y., Shen L., Wong K.Y., Wan T.S.K., Cheung W.L., Chu K.M., Chan L.C., Kwong Y.L., Liang R.H.S. and Srivastava G., CD44 expression is regulated by translocation and promoter hypermethylation in gastric lymphoma, Proceedings of 97th Annual Meeting of American Association for Cancer Research (AACR), Washington D.C., USA, April 2006 . 2006.

Lai K.C., Chu K.M., Hui W.M., Wong B.C.Y., Hu H.C., Wong W.M.R., Chan O.O.A., Wong J. and Lam S.K., Celecoxib compared with lansoprazole and naprosyn to prevent gastrointestinal ulcer complications, American Journal of Medicine. 2005, 118: 1271-1278.

Leung J.C.K., Chan Y.Y., Tang S.C.W., Chu K.M. and Lai K.N., Leptin induces TGF-b synthesis through functional leptin receptor expressed by human peritoneal meoshtelial cell, Kidney International. 2006, 69: 2078-2086.

Leung S.Y., Ho C., Tu I.P., Li R., So S., Chu K.M., Yuen S.T. and Chen X., Comprehensive analysis of 19Q12 amplicon in human gastric cancers, Modern Pathology. 2006, 19: 854-863.

Shin V.Y., Wu K.K., Chu K.M., Wong P.S.H., Lam K.Y., Tai K.K., Koo M.W.L. and Cho C.H., Nicotine induces cyclooxygenase-2 and vascular endothelial growth factor receptor-2 in association with tumor-associated invasion and angiogenesis in gastric cancer, Mol Cancer Res. 2005, 3(11): 607-15.

Tse T.F. and Chu K.M., RON activation by Macrophage Stimulating Protein decreases the cytotoxic effects of chemotherapy on gastric cancer cells via the MAP kinase pathway, Presented at 10th Research Postgraduate Symposium, Faculty of Medince, The University of Hong Kong, Hong Kong, 3 December 2005.. 2005.

Wong W.M.R., Gu Q., Chu K.M., Yee Y.K., Fung F.M.Y., Tong S.M., Chan O.O.A., Lai K.C., Chan C.K. and Wong B.C.Y., Lansoprazole, levofloxacin and amoxicillin triple therapy versus quadruple therapy as second-line treatment of resistant Helicobacter pylori infection, Alimentary Pharmacology & Therapeutics. 2006, 23: 421-427.

Yip B.H., Guo T., Hu X., Wong K.Y., Chen W.Y.W., Au W.Y., Chu K.M., Kwong Y.L., Liang R.H.S. and Srivastava G., Identification of two novel translocations t(14;20)(q32;q12) and t(2;14)(q23;q32) in gastric lymphoma, Proceedings of the 12th Hong Kong International Cancer Congress and 2nd Annual Meeting of Centre for Cancer Research, Hong Kong SAR, China, December 2005.

Yip B.H., Guo T., Hu X., Au W.Y., Wong K.Y., Wan T.S.K., Chen W.Y.W., Chu K.M., Chan L.C., Kwong Y.L., Liang R.H.S. and Srivastava G., Identification of two novel translocations t(14;20)(q32;q12) and t(2;14)(q23;q32) involving immunoglobulin heavy chain gene locus in gastric lymphoma, Proceedings of 97th Annual Meeting of American Association for Cancer Research (AACR), Washington D.C., USA, April 2006.

Researcher : Chu KW

List of Research Outputs

Law W.L. and Chu K.W., Outcomes of resection of stage IV rectal cancer with mesorectal excision, Journal of Surgical Oncology. 2006, 93(7): 523-528.

Yau T.C., Chu K.W., Mok T.M.Y., Liang R.H.S. and Epstein R., Acute presentation of rheumatoid arthritis following cancer chemotherapy using the topoisomerase I inhibitor irinotecan. , Acta Oncologica. 2005, 44(7): 771-772.

Researcher : Chu SSM

List of Research Outputs

Chu T.Y., Tam P.C., Wong C.W., Wong B., Cheung M.C., Chu S.S.M. and Leung S.Y.L., Significance of testicular microlithiasis on ultrasonography findings of symptomatic men (Abstract), Surgical Practice. 2006, 10 (Suppl.): S9.

Researcher : Chung PY

List of Research Outputs

Sun R.W.Y., Chen R., Chung P.Y., Ho C.M., Lin C.L. and Che C.M., Silver nanoparticles fabricated in hepes buffer exhibit cytoprotective activities toward HIV-1 infected cells , Chemical Communications. 2005, 5059-5061.

Wong E.L.M., Sun R.W.Y., Chung P.Y., Lin C.L., Zhu N. and Che C.M., A mixed-valent ruthenium-Oxo Oxalato cluster Na₇[Ru₄(m₃-O)₄(C₂O₄)₆] with potent anti-HIV activities, Journal of the American Chemical Society. 2006, 128: 4398-4399.

Wong S.Y., Sun R.W.Y., Chung P.Y., Lin C.L. and Che C.M., Physiologically stable vandadium (IV) porphyrins as a new class of Anti-HIV agents, Chemical Communications. 2005, 3544-3546.

Researcher : Fan ST

Project Title:	S.K. Yee Medical Foundation Fellowship in hepatobiliary surgery
Investigator(s):	Fan ST
Department:	Surgery
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	11/2000

Abstract:

To train surgeons from less developed cities in China to acquire the technique and knowledge in dealing with complex hepatobiliary problems so as to benefit patients who cannot afford the cost of receiving treatment in cities like Beijing, Shanghai and Guangzhou.

Project Title:	Differential proteomic analysis of biomarkers for primary and recurrent hepatocellular carcinoma
Investigator(s):	Fan ST, Luk JMC, Leng X.S., Peng J.R.
Department:	Surgery
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	12/2003

Abstract:

To identify potential biomarkers for HCC in liver tissues by proteomic analysis; to detect HCC-specific protein biomarkers in serum by ProteinChip; to predict proteomic analysis of HCC patients with high-risk recurrence after surgery.

Project Title:	The potential role of cytoplasmic p27^kip1 on metastatic tumor pathogenesis of hepatocellular carcinoma
Investigator(s):	Fan ST, Wang X, Poon RTP
Department:	Surgery
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2005
Completion Date:	10/2006

Abstract:

The main objectives of this project are to: (1) confim the preliminary observations that p27^kip1 was overexpressed and seemed to be cytoplasmic oncoprotein in the two established metastatic HCC cell lines; (2) determine how phosphorylation of p27^kip1, such as in which phosphorylation sites and by what regulators, mediate mislocalization of p27^kip1 in HCC metastatic cell lines; (3) investigate whether high level of cytoplasmic p27^kip1 in metastatic cell lines results in abnormal cell migration through deregulating the downstream Rho-ROCK-LIMK pathways; (4) Over-express or inhibite the sky components that result from deregulation of p27^kip1 in non-metastatic HCC cell lines to understand their roles in increasing tumor cells invasiveness; (5) explore the potential of reversing HCC metastasis phenotype using a cytoplasmic p27^kip1 silencing xenograft model.

Project Title:	The significance of focal adhesion kinase and cell adhesion kinas &beta and their C-terminal non-kinases in liver cancer invsasion and migration
Investigator(s):	Fan ST, Man K
Department:	Surgery
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2005

Abstract:

The main objective of this project is to study the significance of focal adhesion kinase(FAK) and cell adhesion kinase &beta (CAK&beta) in liver cancer progression and metastasis.

Project Title:	Strategic research theme group on Cancer
Investigator(s):	Fan ST, Ng IOL, Wan JMF, Chiu P, Siu AFM, Chan CLW
Department:	Surgery
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	07/2005

Abstract:

The theme will be on hepatocellular carcinoma (HCC, primary liver cancer) and will focus on factors and strategic leading to long-term survivors. The ultimate aim of cancer research is to detect early tumors and to prolong survival of cancer patients. The studies will focus on biological factors, dietary factors, socio-psychological factors that determine long-term survival and possible alternative medicien that leads to prolonged survival. Tissue and blood stored in the Tissue Bank of the Department of Surgery and Pathology are available for most of the studies. Tumor and blood specimens of forthcoming patients will enhance the pool for validation studies.

Project Title:	Novel Serological Marker for Liver Cancer
Investigator(s):	Fan ST, Ho CY, Cheung ST
Department:	Surgery
Source(s) of Funding:	Small Project Funding
Start Date:	09/2005

Abstract:

Hepatocellular carcinoma (HCC) is the second most common malignant cancer in Hong Kong. Surgical resection remains the treatment of choice for HCC, but unfortunately at the time of diagnosis, only 10-20% of primary HCCs are resectable. Therefore, serological markers specific for HCC are very important for early disease diagnosis especially for patients who are at risk of developing HCC, including patients who are suffering from liver cirrhosis and chronic hepatitis. In addition, the HCC specific serological markers can also facilitate subsequent monitoring of treatment responsiveness and detection of recurrence after curative treatment. To date, serum alpha-fetoprotein (AFP) is the conventional serum marker of HCC, however, it only has 60% sensitivity and 90% of specificity (at 100 ng/ml cutoff) and the sensitivity decreases to 40% for the detection of small tumors and well-differentiated HCC. A novel serological marker independent of differentiation stages for HCC is urgently required. We have performed a genome-wide expression study, in an effort to identify novel serological markers with high sensitivity and specificity for HCC. From this study, we have shown that a secretory protein - Granulin-Epithelin Precursor (GEP) is significantly up-regulated in 76% HCC tumor tissue (30% of these patients are AFP negative). GEP up-regulation is associated with large HCCs, venous infiltration and early intrahepatic recurrence (P < 0.05). Our study has shown that GEP is a novel growth factor and that it is capable of stimulating HCC cell proliferation, invasion and metastasis suggesting that GEP is a very important factor in HCC (Clinical Cancer Research 2004).

List of Research Outputs

Au W.Y., Liu C.L., Lo C.M., Fan S.T. and Lam C.C.K., Living donor liver transplantation for hepatitis C related hepatocellular carcinoma in a haemophilia A patient (Case Report), Haemophilia. 2005, 11(4): 405-407.

Chan F.S.Y., Ng K.K.C., Poon R.T.P., Yuen J.H.F. and Fan S.T., Comparison of radiofrequency ablation and hepatic re-resection for intrahepatic recurrent hepatocellular carcinoma (Abstract), The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2-3 December 2005.

Chan S.C., Liu C.L., Lo C.M., Lam B.K.Y., Lee E.W.M., Wong Y. and Fan S.T., Estimating liver weight of adults by body weight and gender, World Journal of Gastroenterology. 2006, 12(14): 2217-2222.

Chan S.C., Lo C.M. and Fan S.T., Head-to-head comparison of the right and left liver graft in adult-to-adult live donor liver transplantation (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A199.

Chan S.C., Fan S.T., Lo C.M. and Liu C.L., Head-to-head comparison of the right and left liver graft in adult-to-adult live donor liver transplantation (Abstract), The 2006 Joint International Congress of the International Liver Transplantation Society (ILTS), the European Liver and Intestinal Transplant Association (ELITA), and the Liver Intensive Care Group of Europe (LICAGE), Milan, Italy, 3 - 6 May 2006. Liver Transplantation. 2006, 12: C34.

Chan S.C., Lo C.M., Wong Y., Liu C.L. and Fan S.T., Long-term biological consequences of donor right hepatectomy including the middle hepatic vein in adult-to-adult live donor liver transplantation, Liver Transplantation. 2006, 12(2): 259-263.

Chan S.C. and Fan S.T., Right liver adult-to-adult live donor liver transplantation in Hong Kong, Transplantation Reviews. 2006, 20(1): 34-40.

Chan S.C., Fan S.T., Lo C.M. and Liu C.L., Side and size of grafts on surgical outcomes of adult-to-adult live donor liver transplantation (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Chan S.C., Lo C.M., Liu C.L., Wong Y. and Fan S.T., Versatility and viability of hepatic venoplasty in live donor liver transplantation using the right lobe with the middle hepatic vein, Hepatobiliary and Pancreatic Diseases International. 2005, 4(4): 618-621.

Cheung S.T., Wong S.Y., Lee Y.T. and Fan S.T., GEP upregulates wild-type p53 in hepatocellular carcinoma, Oncology Reports. 2006, 15(6): 1507-1511.

Cheung S.T., Wong S.Y. and Fan S.T., Granulin-epithelin precursor and p53 in hepatocellular carcinoma (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A82.

Cheung S.T., Liu C.L., Chow J.P.H., Ng I.O.L. and Fan S.T., Preoperative blood test for prognosis of hepatocellular carcinoma (Abstract), The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2-3 December 2005.

Cheung S.T., Liu C.L., Chow J.P.H., Lee Y.T., Ip Y.C., Ho J.C.Y. and Fan S.T., Preoperative plasma transcript AA454543 level is an independent prognostic factor for hepatocellular carcinoma after partial hepatectomy, The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Chiu A. and Fan S.T., The use of MARS in hepatorenal syndrome – a local perspective, Hong Kong Journal of Nephrology. 2006, 8(1): 5-9.

Chok K.S.H., Yuen W.K., Lau H., Lee F.C.W. and Fan S.T., Five-year experience of outpatient laparoscopic cholecystectomy in Hong Kong, Surgical Practice. 2005, 9(4): 143-146.

Fan S.T., Academician of the Chinese Academy of Engineering (Division of Medicine and Health), 2005.

Fan S.T., Adult-to-adult live donor liver transplantation – our current technique (Abstract), The 15th World Congress of the International Association of Surgeons and Gastroenterologists (and Oncologists), Prague, Czech Republic, 7-10 September 2005.

Fan S.T., Adult-to-adult live donor liver transplantation – our current technique (State-of-the-art Lecture), The 15th World Congress of the International Association of Surgeons and Gastroenterologists (and Oncologists), Prague, Czech Republic, 7 - 10 September 2005. 2005.

Fan S.T. and Liu C.L., Anterior approach for major right hepatic resection (Review Article), Journal of Hepato-Biliary Pancreatic Surgery. 2005, 12(5): 356-361.

Fan S.T., Anterior approach right hepatectomy for hepatocellular carcinoma (Invited Lecture), The 13th International Postgraduate Course, Athens, Greece, 8 - 10 December 2005. 2005.

Fan S.T., Associate Editor (June 2002 - present), Liver Transplantation . 2006.

Fan S.T., Chairman - Liver transplantation for HCC, The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2 - 3 December 2005. 2005.

Fan S.T., Chairman - Plenary session - HCC, The 15th World Congress of the International Association of Surgeons and Gastroenterologists (and Oncologists), Prague, Czech Republic, 7 - 10 September 2005. 2005.

Fan S.T., Chairman, Transplant Centre, Queen Mary Hospital, Hospital Authority, Hong Kong. 2006.

Fan S.T., Chairperson - Case presentations and discussion, Prograf Fukuoka Summit, Fukuoka, Japan, 4 December 2005. 2005.

Fan S.T., Co-moderator - Significance of graft venous congrestion in living donor liver transplantation, The 106th Annual Congress of Japan Surgical Society, Tokyo, Japan, 29 March 2006. 2006.

Fan S.T., Comparison of outcome of live donor liver transplantation for HCC with deceased donor liver transplantation – a single centre experience (Abstract), The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2-3 December 2005.

Fan S.T., Comparison of outcome of live donor liver transplantation for HCC with deceased donor liver transplantation – a single centre experience (Invited Lecture), The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2 - 3 December 2005. 2005.

Fan S.T., Comparison of radiofrequency ablation and resection for hepatocellular carcinoma (Invited Lecture) , Symposium "Image-guided Therapies for Hepatocellular Carcinoma", The 1st World Conference of Interventional Oncology, Lake Komo, Italy, 12 - 14 June 2006. 2006.

Fan S.T., Consultant Surgeon, Queen Mary Hospital, Hospital Authority, Hong Kong. 2006.

Fan S.T., Council Member (January 1998 - present), Hong Kong Chapter, American College of Surgeons. 2006.

Fan S.T., Current status of live donor liver transplantation (Abstract), The 14th Annual Conference of the Indian Association for the Study of the Liver, Nagpur, India, 24-26 February 2006.

Fan S.T., Current status of live donor liver transplantation (Invited Lecture), The 14th Annual Conference of the Indian Association for the Study of the Liver, Nagpur, India, 26 February 2006. 2006.

Fan S.T., Deputy Chief of Service, Department of Surgery, Queen Mary Hospital, Hospital Authority, Hong Kong. 2006.

Fan S.T., Discussant, International Consensus Meeting for the Management of Acute Cholecystitis, Cholangitis, Tokyo, Japan, 1 - 2 April 2006. 2006.

Fan S.T., Doctor of Science, The University of Hong Kong. 2005.

Fan S.T., Expert Clinician, Phoenix Alliance, U.S.A.. 2006.

Fan S.T., Lo C.M., Liu C.L. and Chan S.C., First-class Award of the Chinese State Scientific and Technological Progress Award, 2005.

Fan S.T., Harvesting right liver graft including middle hepatic vein (Abstract), The 106th Annual Congress of Japan Surgical Society, Tokyo, Japan, 29-31 March 2006.

Fan S.T., Harvesting right liver graft including middle hepatic vein (Invited Lecture), The 106th Annual Congress of Japan Surgical Society, Tokyo, Japan, 29 - 31 March 2006. 2006.

Fan S.T., Hepatocellular carcinoma – non-surgical treatment (Abstract), The 15th World Congress of the International Association of Surgeons and Gastroenterologists (and Oncologists), Prague, Czech Republic, 7-10 September 2005.

Fan S.T., Hepatocellular carcinoma – non-surgical treatment (State-of-the-art Lecture), The 15th World Congress of the International Association of Surgeons and Gastroenterologists (and Oncologists), Prague, Czech Republic, 7 - 10 September 2005. 2005.

Fan S.T., Honorary Senior Consultant (Hepatobiliary Surgery), Tung Wah Hospital, Hospital Authority, Hong Kong. 2006.

Fan S.T., How to decrease morbidity and mortality in extended liver resection (Abstract), The 15th World Congress of the International Association of Surgeons and Gastroenterologists (and Oncologists), Prague, Czech Republic, 7-10 September 2005.

Fan S.T., How to decrease morbidity and mortality in extended liver resection (State-of-the-art Lecture), The 15th World Congress of the International Association of Surgeons and Gastroenterologists (and Oncologists), Prague, Czech Republic, 7 - 10 September 2005. 2005.

Fan S.T., Invited commentary on "regeneration and function of hemiliver graft: right versus left", Surgery. 2006, 139(6): 772-773.

Fan S.T., Liver transplant in Hong Kong (Invited Lecture), Seminar on Organ Donation / Transplantation for KCC Nurses, Continuing Nursing Education, Kowloon Central Cluster, Hospital Authority, Hong Kong, 10 June 2006. 2006.

Fan S.T., Liver transplantation for HCC (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March, 2006.

Fan S.T., Liver transplantation for HCC (Presidential Lecture), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25 - 28 March 2006. 2006.

Fan S.T., Liver transplantation in the Asia Pacific Region (Abstract), The 16th Conference of the Asian Pacific Association for the Study of the Liver, Manila, Philippines, 5-8 March 2006.

Fan S.T., Liver transplantation in the Asia Pacific Region (Plenary Lecture), The 16th Conference of the Asian Pacific Association for the Study of the Liver, Manila, Philippines, 5 - 8 March 2006. 2006.

Fan S.T., Liver transplantation in the Asia Pacific region – trials and tribulations (Invited Lecture), The 4th Malaysian Liver Foundation Award in the 6th Liver Update, Kuala Lumpur, Malaysia, 21 - 24 July 2005. 2005.

Fan S.T., Liver transplantation in the Asia Pacific region – trials and tribulations, Medical Journal of Malaysia. 2005, 60(Suppl B): 1-4.

Fan S.T., Member at Large, Executive Committee, International Gastro-Surgical Club. 2006.

Fan S.T., Member of Editorial Board, 消化外科, 2006.

Fan S.T., Member of Editorial Board (1991 - present), Journal of Gastroenterology and Hepatology. 2006.

Fan S.T., Member of Editorial Board (1995 - present), Hepato-Gastroenterology. 2006.

Fan S.T., Member of Editorial Board (1998 - present), Archives of Surgery. 2006.

Fan S.T., Member of Editorial Board (2001 - present), 中國肝癌雜誌, 2006.

Fan S.T., Member of Editorial Board (December 1998 - present), Nutrition. 2006.

Fan S.T., Member of Editorial Board (December 2002 - present), 中國普外基礎與臨床雜誌, 2006.

Fan S.T., Member of Editorial Board (December 2003 - present), 中華外科治療學雜誌, 2006.

Fan S.T., Member of Editorial Board (December 2003 - present), 移植雜誌, 2006.

Fan S.T., Member of Editorial Board (January 1993 - present), Hong Kong Practitioner. 2006.

Fan S.T., Member of Editorial Board (January 1999 - present), 中華普通外科雜誌, 2006.

Fan S.T., Member of Editorial Board (January 2000 - present), 中華醫學雜誌, 2006.

Fan S.T., Member of Editorial Board (January 2000 - present), Asian Journal of Surgery. 2006.

Fan S.T., Member of Editorial Board (January 2000 - present), Journal of Hepatobiliary Pancreatic Surgery (Japan). 2006.

Fan S.T., Member of Editorial Board (January 2005 - present), Current Nutrition and Food Science. 2006.

Fan S.T., Member of Editorial Board (January 2005 - present), Transplantation. 2006.

Fan S.T., Member of Editorial Board (July 1999 - present), HPB. 2006.

Fan S.T., Member of Editorial Board (July 2001 - present), 中國實用外科雜誌, 2006.

Fan S.T., Member of Editorial Board (May 1998 - present), 中華肝膽外科雜誌, 2006.

Fan S.T., Member of Editorial Board (October 1999 - present), Digestive Surgery. 2006.

Fan S.T., Member of Editorial Board (October 2001 - present), Hepatobiliary and Pancreatic Diseases International. 2006.

Fan S.T., Member of Editorial Board (October 2004 - present), World Journal of Gastroenterology. 2006.

Fan S.T., Member of Editorial Board, British Journal of Surgery. 2006.

Fan S.T., Member of Editorial Board, Journal of Cancer Research and Clinical Oncology. 2006.

Fan S.T., Member of Subcommittee, Service Development in Surgery, Hospital Authority, Hong Kong. 2006.

Fan S.T., Moderator - ISS/SIC symposium - pancreas, International Surgical Week 2005, The 41st World Congress of Surgery of the International Society of Surgery/Société Internationale de Chirurgie, Durban, South Africa, 21 - 25 August 2005. 2005.

Fan S.T., Moderator - Session I – Overview experience of LDLT, 2006 Living Donor Liver Transplantation Symposium, Tokyo, Japan, 30 March 2006. 2006.

Fan S.T., National Delegate (April 1996 - present), International Society of Surgery (ISS) Societe Internationale de Chirurgie (SIC). 2006.

Fan S.T., Overview of surgical treatments (Invited Lecture), The 1st Lui Hac Minh Symposium – Advanced Radiation Technology for Liver Cancer, Department of Clinical Oncology, Pamela Youde Nethersole Eastern Hospital, Hong Kong, 25 March 2006. 2006.

Fan S.T., Panel Member - Symposium on HPB training worldwide – Asia Pacific, American Hepato-Pancreato-Biliary Association Annual Meeting, Miami, U.S.A., 9 - 13 March 2006. 2006.

Fan S.T., Patient assessment for improving graft survival (Abstract), Prograf Fukuoka Summit, Fukuoka, Japan, 4 December 2005.

Fan S.T., Lo C.M., Liu C.L. and Chan S.C., Pre-transplant live liver donor evaluation and perioperative care. Protocol of Queen Mary Hospital, University of Hong Kong (Abstract), Vancouver Forum on the Medical Care of the Live Lung, Liver, Intestinal and Pancreas Donor, Vancouver, Canada, 14-16 September 2005.

Fan S.T., Pre-transplant live liver donor evaluation and perioperative care. Protocol of Queen Mary Hospital, University of Hong Kong (Forum), Vancouver Forum on the Medical Care of the Live Lung, Liver, Intestinal and Pancreas Donor, The Transplantation Society, Vancouver, Canada, 16 September 2005. 2005.

Fan S.T., Prevention and treatment of HBV recurrence after liver transplantation (Abstract), The 16th Conference of the Asian Pacific Association for the Study of the Liver, Manila, Philippines, 5-8 March 2006.

Fan S.T., Prevention and treatment of HBV recurrence after liver transplantation (Invited Lecture), The 16th Conference of the Asian Pacific Association for the Study of the Liver, Manila, Philippines, 5 - 8 March 2006. 2006.

Fan S.T., Protection of liver remnant during partial hepatectomy (Invited Lecture), The 13th International Postgraduate Course, Athens, Greece, 8 - 10 December 2005. 2005.

Fan S.T., Reviewer, American Journal of Gastroenterology. 2006.

Fan S.T., Reviewer, American Journal of Surgery. 2006.

Fan S.T., Reviewer, American Journal of Transplantation. 2006.

Fan S.T., Reviewer, Annals of Surgery. 2006.

Fan S.T., Reviewer, Archives of Surgery. 2006.

Fan S.T., Reviewer, Asian Journal of Surgery. 2006.

Fan S.T., Reviewer, British Journal of Surgery. 2006.

Fan S.T., Reviewer, Digestive Surgery. 2006.

Fan S.T., Reviewer, Gut. 2006.

Fan S.T., Reviewer, HBP Surgery. 2006.

Fan S.T., Reviewer, Hepatology. 2006.

Fan S.T., Reviewer, Intensive Care Medicine. 2006.

Fan S.T., Reviewer, Journal of Cancer Research and Clinical Oncology. 2006.

Fan S.T., Reviewer, Journal of Gastroenterology and Hepatology. 2006.

Fan S.T., Reviewer, Journal of Hepato-Biliary-Pancreatic Surgery. 2006.

Fan S.T., Reviewer, Journal of Surgical Research. 2006.

Fan S.T., Reviewer, Journal of the Pancreas. 2006.

Fan S.T., Reviewer, Liver Transplantation. 2006.

Fan S.T., Reviewer, Nutrition. 2006.

Fan S.T., Reviewer, Surgery. 2006.

Fan S.T., Reviewer, Transplantation. 2006.

Fan S.T., Reviewer, World Journal of Gastroenterology. 2006.

Fan S.T., Reviewer, World Journal of Surgery. 2006.

Fan S.T., Right liver LDLT – duct-to-duct anastomosis (Invited Lecture), The 4th International Meeting on Living Donor Liver and Kidney Transplantation, Barcelona, Spain, 14 - 15 November 2005. 2005.

Fan S.T., Right liver donor evaluation and result (Invited Lecture), The 4th International Meeting on Living Donor Liver and Kidney Transplantation, Barcelona, Spain, 14 - 15 November 2005. 2005.

Fan S.T., Right liver graft and outflow reconstruction (Abstract), The 3rd Internatinoal Conference of Living Donor Abdominal Organ Transplantation: State of the Art, Cagliari, Italy, 23-24 June 2006.

Fan S.T., Right liver graft and outflow reconstruction (Invited Lecture), The 3rd Internatinoal Conference of Living Donor Abdominal Organ Transplantation: State of the Art, Cagliari, Italy, 23 - 24 June 2006. 2006.

Fan S.T., Right liver graft with or without the middle hepatic vein (Invited Lecture), The 4th International Meeting on Living Donor Liver and Kidney Transplantation, Barcelona, Spain, 14 - 15 November 2005. 2005.

Fan S.T., Surgery for cholangiocarcinoma: the Eastern experience (Invited Lecture), International Surgical Week 2005, The 41st World Congress of Surgery of the International Society of Surgery/Société Internationale de Chirurgie, Durban, South Africa, 21 - 25 August 2005. 2005.

Fan S.T., The patient assessment for improving the graft survival (Invited Lecture), Prograf Fukuoka Summit, Fukuoka, Japan, 4 December 2005. 2005.

Fan S.T., Transmission of infection from live donor to recipient (Invited Commentary), Transplantation. 2006, 81(1): 16.

Fan S.T., 肝移植, In: 鄒聲泉、龔建平, 外科學—前沿與爭論, 人民衛生出版社, 2006, 632-638.

Fan S.T., 肝葉切除術及其併發症的防治 (Abstract), 中國合肥安徽醫科大學第一附屬醫院肝膽胰手術與內鏡技術繼續教育學習班, 2005年7月1日, 2005.

Fan S.T., 肝葉切除術及其併發症的防治 (Invited Lecture), 中國合肥安徽醫科大學第一附屬醫院肝膽胰手術與內鏡技術繼續教育學習班, 2005年7月1日, 2005.

Fan S.T., 右葉活體肝移植—我們目前的技術 (Invited Lecture), 中國濟南全國外科學術會議, 2005年10月30日, 2005.

Fan S.T., 中國肝移植註冊2005年度總結 (Invited Lecture), 中國昆明第三屆全國器官移植學術會議, 2006年5月28日, 2006.

Ho J.C.Y., Cheung S.T. and Fan S.T., Novel serological marker for hepatocellular carcinoma (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Ho J.W.Y., Man K., Sun K.W., Lee K.W., Poon R.T.P. and Fan S.T., Effects of a novel immunomodulating agent, FTY720, on tumor growth and angiogenesis in hepatocellular carcinoma, Molecular Cancer Therapeutics. 2005, 4(9): 1430-1438.

Hui C.K., Lai L.S., Lam P., Zhang H., Fung T.T., Lai S.T., Wong W.M., Lo C.M., Fan S.T., Leung N. and Lau G., 48 weeks pegylated interferon alpha-2a is superior to 24 weeks of pegylated interferon alpha-2b in achieving hepatitis B e antigen seroconversion in chronic hepatitis B infection, Alimentary Pharmacology and Therapeutics. 2006, 23(8): 1171-1178.

Hui C.K., Lau E., Kim M., Monto A., Luk J.M., Leung N., Lo C.M., Fan S.T., Wright T.L. and Lau G., Fibrosis Porgression in Patients with Recurrent Chronic Hepatitis C Virus and Occult Hepatitis B Co-Infection After Liver transplantation, J Gastroenterol and Hepatol. 2006, 21(2): A80.

Hui C.K., Lau E., Kim M., Monto A., Luk J.M.C., Leung N., Lo C.M., Fan S.T., Wright T.L. and Lau G., Fibrosis progression in patients with recurrent chronic hepatitis C virus and occult hepatitis B co-infection after liver transplantation (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A80.

Hui C.K., Lau E., Monto A., Kim M., Luk J.M.C., Poon R.T.P., Leung N., Lo C.M., Fan S.T. and Lau G., Natural history of patients with recurrent chronic hepatitis C virus and occult hepatitis B co-infection after liver transplanation, AM J Transplanation. 2006, 6(7): 1600-8.

Hui C.K., Zhan H.Y., Lee N.P., Yueng Y.H., Lu L., Leung N., Wong B.C., Lo C.M., Fan S.T., Luk J.M.C. and Lau G., Upregulation of toll-like receptor 7 is essential for serological clearance of hepatitis B surface antigen in chronic hepatitis B (HBV) infection, Hepatology. 2005, 42(4): 707A-708A, Suppl 1.

Hui C.K., Zhang H., Lee N.W., Lu L., Leung N., Wong B.C.Y., Lo C.M., Fan S.T., Luk J.M.C. and Lau G., Upregulation of toll-like receptor 7 is essential for serological clearance of hepatitis B surface antigen in chronic hepatitis B virus (HBV) infection, Liver International 2005. 2005, Oct: 196.

Ip Y.C., Cheung S.T. and Fan S.T., MT1-MMP in relation to metastasis of hepatocellular carcinoma (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Ip Y.C., Cheung S.T., Leung K.L. and Fan S.T., Mechanism of metastasis by membrane type 1-matrix metalloproteinase in hepatocellular carcinoma, World Journal of Gastroenterology. 2005, 11(40): 6269-6276.

Lai L.S.W., Fung T.T., Lai S.T., Yiu J., Lam P., Zhang H., Wong W.M., Lo C.M., Fan S.T., Hui C.K., Leung N. and Lau G., 48 weeks pegylated interferon alfa-2a is superior to 24 weeks of pegylated interferon alfa-2b in achieving HBeAg seroconversion in chronic hepatitis B infection (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A90.

Lai S.W., Fung S.T., Lai S.T., Yiu J., Lam P., Zhang H.Y., Wong W.M., Lo C.M., Fan S.T., Leung N. and Lau G., 48 Weeks Pegylated Interferon Alfa-2a is superior to 24 Weeks of Pegylated interferon Alfa-2b in Achieving HBeAg seroconversion in Chronic Hepatitis Infection, J Gastronenterol and Hepatol. 2006, 21(2): A90.

Lam C.M., Yong J.L., Chan O.O., Ng K.K.C., Poon R.T.P., Liu C.L., Lo C.M. and Fan S.T., Better survival in female patients with hepatocellular carcinoma: oral contraceptive pills related?, Journal of Clinical Gastroenterology. 2005, 39(6): 533-539.

Lam C.M., Yuen A.W.C., Chik B., Wai A.C. and Fan S.T., Variation in the use of laparoscopic cholecystectomy for acute cholecystitis: a population-based study, Archives of Surgery. 2005, 140(11): 1084-1088.

Lam S., Man K., Ng T.P., Fan S.T. and Lo C.M., The significance of hepatic stellate cell activation in small-for-size fatty liver graft injury (Abstract), The 11th Congress of the International Liver Transplantation Society, Los Angeles, U.S.A., 20 - 23 July 2005.

Lee K.W., Man K., Ho J.W.Y., Wang X., Poon R.T.P., Xu Y., Ng T.P., Chu A.C.Y., Sun K.W., Ng I.O.L., Sun H.C., Tang Z.Y., Xu R. and Fan S.T., FTY720: a promising agent for treatment of metastatic hepatocellular carcinoma, Clinical Cancer Research. 2005, 11(23): 8458-8466.

Lee K.W., Poon R.T.P., Tang Z.Y., Sun H.C. and Fan S.T., Identification of L1CAM as the potential biomarker for HCC metastasis (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A78.

Lee K.W., Poon R.T.P., Man K., Guan X.Y. and Fan S.T., Identification of biomarkers for metastatic hepatocellular carcinoma (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Lee K.W., Poon R.T.P. and Fan S.T., Rac activiation is associated with HCC metastasis through upregulation of VEGF in hepatocellular carcinoma (Abstract), The 97th Annual Meeting of the American Association of Cancer Research, Washington D.C., U.S.A., 1 - 5 April 2006.

Lee P.Y., Leung K.W., Sham P.C., Lau G., Fan S.T. and Luk J.M., Proteomic Expression Clustering of Mourse Liver Development Stages, J Gastroenterol and Hepatol . 2006, 21(2): A218.

Lee P.Y., Leung K.W., Sham P.C., Lau G., Fan S.T. and Luk J.M.C., Proteomic expression clustering of mouse liver developmental stages (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A218.

Leung T.M., Tipoe G.L., Fan S.T., Liong E.C., Fung M.L. and Nanji A.A., Endothelial nitric oxide synthase is an important factor in the progression of liver fibrosis, Hepatology. 2005, 597A No.1019.

Liem M.S.L., Poon R.T.P., Lo C.M., Tso W.K. and Fan S.T., Outcome of transarterial chemoembolization in patients with inoperable hepatocellular carcinoma eligible for radiofrequency ablation, World Journal of Gastroenterology. 2005, 11(29): 4465-4471.

Liem M.S.L., Liu C.L., Tso W.K., Lo C.M., Fan S.T. and Wong J., Portal vein embolisation prior to extended right-sided hepatic resection, Hong Kong Medical Journal. 2005, 11(5): 366-372.

Liu C.L. and Fan S.T., Adult-to-adult live-donor liver transplantation: the current status (Invited Paper), Journal of Hepato-Biliary-Pancreatic Surgery. 2006, 13(2): 110-116.

Liu C.L., Fan S.T., Cheung S.T., Lo C.M., Ng I.O.L. and Wong J., Anterior approach versus conventional approach right hepatic resection for large hepatocellular carcinoma: a prospective randomised controlled study (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Liu C.L., Fan S.T., Lo C.M., Tso W.K., Wong Y., Poon R.T.P., Lam C.M., Wong B.C.Y. and Wong J., Clinicobiochemical prediction of biliary cause of acute pancreatitis in the era of endoscopic ultrasonography, Alimentary Pharmacology and Therapeutics. 2005, 22(5): 423-431.

Liu C.L., Fan S.T., Lo C.M., Tso W.K., Wong Y., Poon R.T.P., Lam C.M., Wong B.C.Y. and Wong J., Comparison of early endoscopic ultrasonography and endoscopic retrograde cholangiopancreatography in the management of acute biliary pancreatitis: a prospective randomized study, Clinical Gastroenterology and Hepatology. 2005, 3(12): 1238-1244.

Liu C.L., Fan S.T., Lo C.M., Wei W.I., Chan S.C., Yong B.H. and Wong J., Operative outcomes of adult-to-adult right lobe live donor liver transplantation: a comparative study with cadaveric whole-graft liver transplantation in a single center, Annals of Surgery. 2006, 243(3): 404-410.

Liu C.L., Lo C.M. and Fan S.T., What is the best technique for right hemiliver living donor liver transplantation? With or without the middle hepatic vein? Duct-to-duct biliary anastomosis or Roux-en-Y hepaticojejunostomy? (Invited Article), Journal of Hepatology. 2005, 43(1): 17-22.

Liu Y., Poon R.T.P., Qian X.M., Li L., Lau C.P.Y., Chen Y.J., Kok T.W. and Fan S.T., A study of the effect of vascular endothelial growth factor tyrosine kinase inhibitor PTK 787/ZK222584 on liver fibrosis (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Liu Y., Poon R.T.P., Li L., Qian X., Chen Y.J., Yang X., Sun H.C., Tang Z.Y. and Fan S.T., Synergistic inhibitory effects of PTK787/ZK222584 and interferon-alfa on hepatocellular carcinoma with metastatic potential (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25 - 28 March 2006.

Liu Y., Poon R.T.P., Li L., Qian X., Chen Y., Xu Y., Sun H.C., Tang Z.Y. and Fan S.T., Synergistic inhibitory effects of PTK787/ZK222584 and interferon-alfa on hepatocellular carcinoma with metastatic potential (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A94.

Lo C.M., Liu C.L., Lau G., Fan S.T. and Chan S.C., Failure of hepatitis B vaccination in patients receiving lamivudine prophylaxis after liver transplantation for chronic hepatitis B, Journal of Hepatology. 2005, 43(2): 283-287.

Lo C.M., Cheung C.K.Y., Lau G., Yuen R.M.F., Liu C.L., Chan S.H.C., Fan S.T. and Wong J., Significance of hepatitis B virus genotype in liver transplantation for chronic hepatitis B, American Journal of Transplantation. Blackwell, 2005, 5: 1893-900.

Luk J.M.C., Chen L., Lam B.K.Y., Ho D.W.Y., Peng J.R., Leng X.S., Hui C.K., Lau G., Yip T.T. and Fan S.T., Comparing serum alpha-fetoprotein level and SELDI-TOF-MS profiling for diagnosis of hepatocellular carcinoma (Abstract), The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2-3 December 2005.

Luk J.M.C., Chen L., Lam B., Ho D., Peng J., Leng J., Leng X., Hui C.K., Lau G., Yip T.T. and Fan S.T., Comparing serum alpha-fetoprotein level and SELDI-TOF-MS profilling for diagnosis of hepatocellular carcinoma. The 4th JSH Single Topic conference on hepatocellular carcinoma. , Hoyogo, Japan. 2005, Dec2-3, 05.

Luk J.M.C., Wang P.P., Lee C.K.F., Wang J.H. and Fan S.T., Hepatic potential of bone marrow stromal cells: development of in vitro co-culture and intra-portal transplantation models, Journal of Immunological Methods. 2005, 305(1): 39-47.

Luk J.M.C., Zhang Q., Wo J., Leung P.P., Hu M.Y., Lau G. and Fan S.T., Hepatic stellate cell-targeted delivery of 18beta-glycyrrhetinic acid modulates bile duct ligation-induced fibrosis in rat liver, Hepatology. 2005, 42(4): 266A-266A Suppl 1.

Luk J.M.C., Fan S.T., Xin Y., Peng J.R. and Leng X.S., Proteomic identification of stress-response heat shock protein markers associated with tumor recurrence in patients with hepatocellular carcinoma (Abstract), The Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A75.

Luk J.M.C., Lam C.T., Siu A.F.M., Lam B.Y.H., Ng I.O.L., Hu M.Y., Che C.M. and Fan S.T., Proteomic profiling of hepatocellular carcinoma in Chinese cohort reveals heat-shock proteins (Hsp27, Hsp70, GRP78) up-regulation and their associated prognostic values, Proteomics . 2006, 6(3): 1049-1057.

Luk J.M.C., Peng J.R., Leng X.S. and Fan S.T., Proteomics and biomarker discovery for hepatocellular carcinoma (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Lum C.T., Yang Z., Li H.Y., Sun R.W.Y., Fan S.T., Poon R.T.P., Lin M.C., Che C.M. and Kung H., Gold(III) compound is a novel chemocytotoxic agent for hepatocellular carcinoma, International Journal of Cancer. 2006, 118(6): 1527-1538.

Mak C.M., Tam S., Fan S.T., Liu C.L. and Lam C.W., Wilson's disease: a patient undiagnosed for 18 years, Hong Kong Medical Journal. 2006, 12(2): 154-158.

Man K., Zhao Y., Xu A., Lo C.M., Lam K.S.L., Ng T.P., Ho J.W.Y., Sun K.W., Lee K.W., Li X. and Fan S.T., Fat-derived hormone adiponectin combined with FTY720 significantly improves small-for-size fatty liver graft survival, American Journal of Transplantation. 2006, 6(3): 467-476.

Man K., Su M., Ng T.P., Lo C.M. and Fan S.T., Rapamycin attenuates liver graft injury in a cirrhotic rat liver transplantation model - the significance of down-regulation of Rho-ROCK pathway (Abstract), The 11th Congress of the International Liver Transplantation Society, Los Angeles, U.S.A., 20 - 23 July 2005.

Man K., Su M., Ng T.P., Lo C.M., Zhao Y., Ho J.W.Y., Sun K.W., Lee K.W. and Fan S.T., Rapamycin attenuates liver graft injury in cirrhotic recipient - the significance of down-regulation of Rho-ROCK-VEGF pathway, American Journal of Transplantation. 2006, 6(4): 697-704.

Man K., Lo C.M., Ng T.P., Sun K.W. and Fan S.T., Significant activation of cell invasion, migration and angiogenesis pathways in small-for-size grafts may potentially increase tumor recurrence after living donor liver transplantation (Abstract), The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2-3 December 2005.

Man K., Lo C.M., Ng T.P., Xiao J., Sun K.W., Su M. and Fan S.T., Significant activation of cell invasion, migration and angiogenesis pathways in small-for-size grafts may potentially increase tumour recurrence after living donor liver transplantation (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Man K., Lo C.M., Ng T.P., Ng T.P., Sun K.W. and Fan S.T., Significant activation of cell invasion, migration and angiogensis pathways in small-for-size grafts may potential increase tumor recurrence after living donor liver transplantation (Abstract), The 11th Congress of the International Liver Transplantation Society, Los Angeles, U.S.A., 20 - 23 July 2005.

Man K., Lo C.M., Ng T.P., Sun K.W. and Fan S.T., The significance of acute phase graft injury on tumor recurrence and metastases in living donor liver transplantation (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A204.

Man K., Sun K.W., Liu C.L., Ng T.P., Ho J.W.Y., Poon R.T.P. and Fan S.T., The significance of cell adhesion kinase in recurrence of hepatocellular carcinoma after curative liver resection (Abstract), The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2-3 December 2005.

Man K., Lo C.M., Xiao J.W., Ng T.P., Ng I.O.L., Sun K.W., Cheng Q. and Fan S.T., The significance of graft size on tumor recurrence/metastases after liver transplantation – Activation of cell invasion and migration pathways (Abstract), The 2006 Joint International Congress of the International Liver Transplantation Society (ILTS), the European Liver and Intestinal Transplant Association (ELITA), and the Liver Intensive Care Group of Europe (LICAGE), Milan, Italy, 3 - 6 May 2006. Liver Transplantation. 2006, 12: C30.

Ng K.K.C., Poon R.T.P., Chan F.S.Y., Yuen J.H.F., Tso W.K. and Fan S.T., Comparison of radiofrequency ablation and hepatic re-resection for intrahepatic recurrent hepatocellular carcinoma (Oral Presentation), The 106th Annual Congress of Japan Surgical Society, Tokyo, Japan, 29-31 March 2006.

Ng K.K.C., Poon R.T.P., Lam C.M., Yuen J.H.F., Tso W.K. and Fan S.T., Efficacy and safety of radiofrequency ablation for perivascular hepatocellular carcinoma without hepatic inflow occlusion, British Journal of Surgery. 2006, 93(4): 440-447.

Ng K.K.C. and Fan S.T., General Surgery Review. Makary MA (ed) Washington, D.C.: Ladner-Drysdale. 2004: 386, British Journal of Sugery. 2005, 92: 898.

Ng K.K.C., Lo C.M., Chan S.C. and Fan S.T., Increasing applicability of liver transplantation over 13 years - a single institution experience (Oral Presentation), The Annual Scientific Meeting of the Hong Kong Society of Transplantation, Hong Kong, 2 April 2006.

Ng K.K.C., Poon R.T.P., Lo C.M., Yuen J.H.F., Tso W.K. and Fan S.T., Recurrence pattern and survival outcome after radiofrequency ablation of hepatocellular carcinoma (Abstract), The 16th World Congress of the International Association of Surgeons and Gastroenterologists, Madrid, Spain, 25 - 27 May 2006.

Ng K.K.C., Lam C.M., Poon R.T.P., Shek T.W.H., Ho D.W.Y. and Fan S.T., Safety limit of large-volume hepatic radiofrequency ablation in a rat model, Archives of Surgery. 2006, 141(3): 252-258.

Ng K.K.C., Poon R.T.P., Lo C.M., Liu C.L. and Fan S.T., Survival analysis of patients with transplantable hepatocellular carcinoma: an implication for salvage transplantation (Abstract), The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2-3 December 2005.

Ng K.K.C., Poon R.T.P., Lo C.M., Liu C.L., Lam C.M. and Fan S.T., Survival analysis of patients with transplantable recurrent hepatocellular carcinoma: an implication for salvage liver transplantation (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Pang R.W.C., Poon R.T.P., Lee K.W., Fan S.T., Kwong Y.L. and Tse E.W.C., PIN1 interacts with a specific serine-proline motif of hepatitis B virus X protein to enhance hepatocarcinogenesis (Abstract), The 97th Annual Meeting of the American Association of Cancer Research, Washington D.C., U.S.A., 1 - 5 April 2006.

Patil M.A., Gutgemann I., Zhang J., Ho C., Cheung S.T., Ginzinger D., Li R., Dykema K.J., So S., Fan S.T., Kakar S., Furge K.A., Buttner R. and Chen X., Array-based comparative genomic hybridisation reveals recurrent chromosomal aberrations and Jab1 as a potential target for 8q gain in hepatocellular carcinoma, Carcinogenesis. 2005, 26(12): 2050-2057.

Patil M.A., Zhang J., Ho C., Cheung S.T., Fan S.T. and Chen X., Hedgehog signaling in human hepatocellular carcinoma, Cancer Biology and Therapy. 2006, 5(1): 111-117.

Poon R.T.P., Lee K.W., Yuen P.W., Ling M.T., Wang X., Wong Y.C., Guan X.Y., Man K. and Fan S.T., Id-1 promotes angiogenesis in hepatocellular carcinoma through HIF-1a-mediated VEGF upregulation (Abstract), The 97th Annual Meeting of the American Association of Cancer Research, Washington D.C., U.S.A., 1 - 5 April 2006.

Tam P.K.H., Poon R.T.P., Yang Z. and Fan S.T., mTOR inhibitor enhances chemosensitivity of hepatocellular carcinoma (Abstract), The 97th Annual Meeting of the American Association of Cancer Research, Washington D.C., U.S.A., 1 - 5 April 2006.

Tang C.M., Poon R.T.P. and Fan S.T., The significance of cyclooxygenase-2 expression in human hepatocellular carcinoma (Review Article), Biomedicine and Pharmacotherapy. 2005, 59(Suppl 2): S311-S316.

Tsui T.Y., Lau C.K., Ma J., Glockzin G., Obed A., Schlitt H.J. and Fan S.T., Adeno-associated virus-mediated heme oxygenase-1 gene transfer suppresses the progression of micronodular cirrhosis in rats, World Journal of Gastroenterology. 2006, 12(13): 2016-2023.

Tsui T.Y., Siu Y.T., Ho D.W.Y., Ma J., Lau C.K., Schlitt H.J. and Fan S.T., Heme oxygenase-1-derived carbon monoxide stimulates adenosine triphosphate generation in human hepatocyte, Biochemical and Biophysical Research Communications. 2005, 336(3): 898-902.

Tsui T.Y., Lau C.K., Ma J., Wu X., Wang Y., Farkas S., Xu R., Schlitt H.J. and Fan S.T., rAAV-mediated stable expression of heme oxygenase-1 in stellate cells: a new approach to attenuate liver fibrosis in rats, Hepatology. 2005, 42(2): 335-342.

Wang X., Redpath J.L., Fan S.T. and Stanbridge E.J., ATR dependent activation of Chk2 and Chk1, Journal of Cellular Physiology. 2006, 208: 613-619.

Wang X., Stanbridge E.J. and Fan S.T., Chemotherapy increases expression of stem cell marker and cell migration in hepatocellular carcinoma (Abstract), The 4th International Society for Stem Cell Research Annual Meeting, Toronto, Canada, 29 June - 1 July 2006.

Wang X. and Fan S.T., Role of Chk1 in preventing G2 checkpoint abrogation in wild type p53 cells (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Wang Y., Luk J.M.C., Chu A.C.Y., Ikeda K., Man K., Kaneda K. and Fan S.T., TNP-470 blockage of VEGF synthesis is dependent on MAPK/COX-2 signaling pathway in PDGF-BB-activated hepatic stellate cells, Biochemical and Biophysical Research Communications. 2006, 341-(1): 239-244.

Wong K.F., Fan S.T. and Luk J.M.C., Immunochemical characterization of tripterygium wifordii (triptolide, triptonide and synthetic racemic derivatives) immunosupppressive properties in allogenic mixed lymphocyte reaction (Abstract) (Best poster presentation award), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25 - 28 March 2006. 2006.

Wong K.F., Fan S.T. and Luk J.M.C., Immunochemical characterization of tripterygium wilfordii (triptolide, triptonide and synthetic racemic derivatives) immunosuppressive properties in allogenic mixed lymphocyte reaction (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A219.

Wong K.K.Y., Fan S.T. and Tam P.K.H., Pitfalls of performing Kasai portoenterostomy: a perspective from a liver transplantation centre, 39th Annual Meeting of the Pacific Association of Pediatric Surgeons, Taipei, Taiwan, 14-18 May 2006.

Wu J., Ma J., Fan S.T., Schlitt H.J. and Tsui T.Y., Bilirubin derived from heme degradation suppresses MHC class II expression in endothelial cells, Biochemical and Biophysical Research Communications. 2005, 338(2): 890-896.

Xu X., Man K., Zheng S.S., Liang T.B., Lee K.W., Ng T.P., Fan S.T. and Lo C.M., Attenuation of acute phase shear stress by somatostatin improves small-for-size liver graft survival, Liver Transplantation. 2006, 12(4): 621-627.

Yang Z., Ho D.W.Y., Lau C.K., Lam C.T., Lum C.T., Poon R.T.P. and Fan S.T., Allograft inflammatory factor-1 (AIF-1) is crucial for the survival and pro-inflammatory activity of macrophages, International Immunology. 2005, 17(11): 1391-1397.

Yang Z., Liu Y., Ho D.W.Y., Lau C.K., Poon R.T.P. and Fan S.T., Blockade of vascular endothelial growth factor (VEGF) receptor enhances the therapeutic efficacy of hypoxia and chemotherapy in hepatocellular carcinoma (Poster Presentation), The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2 - 3 December 2005.

Yang Z., Lau C.K., Ngai P.P., Ho D.W.Y., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Delayed immunosuppression induces long-term liver allograft survival through interleukin-10 (IL-10) dependent manner (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Yang Z., Poon R.T.P. and Fan S.T., Interplay between BDNF and platelet in hepatocellular carcinoma (Poster Presentation), The 97th Annual Meeting of the American Association of Cancer Research, Washington D.C., U.S.A., 1 - 5 April 2006.

Yang Z., Lau C.K., Ngai P.P., Ho D.W.Y., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Short-term cardiotrophin-1 (CT-1) rescues marginal cirrhotic liver remnant after major hepatectomy without increasing the risk of tumor recurrence (Oral Presentation), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A92.

Yang Z., Ngai P.P., Lau C.K., Tam K.H., Ho D.W.Y., To J.Y.T., Poon R.T.P. and Fan S.T., Transient production of interleukin-10 (IL-10) by residual macrophages is crucial for the ischemia/reperfusion injury and long-term allograft survival in liver transplantation (Oral Presentation), The 8th International Congress of the Cell Transplant Society, Milan, Italy, 24 - 26 May 2006.

Yeung Y.P., Lo C.M., Liu C.L., Wong B.C.Y., Fan S.T. and Wong J., Natural history of untreated nonsurgical hepatocellular carcinoma, American Journal of Gastroenterology. 2005, 100(9): 1995-2004.

Zender L., Spector M.S., Xue W., Flemming P., Cordon-Cardo C., Silke J., Fan S.T., Luk J.M.C., Wigler M., Hannon G.J., Mu D., Lucito R., Powers S. and Lowe S.W., Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach, Cell. 2006, 125(7): 1253-1267.

Researcher : Fan YW

List of Research Outputs

Leung G.K.K. and Fan Y.W., Chronic subdural haematoma associated with arachnoid cyst in autosomal dominant polycystic kidney disease (ADPKD), Journal of Clinical Neuroscience. 2005, 12(7): 817-819.

Leung G.K.K., Auyeung K.M., Lui W.M. and Fan Y.W., Emergency placement of a self-expandable covered stent for carotid artery injury during trans-sphenoidal surgery, British Journal of Neurosurgery. 2006, 20(1): 55-57.

Wei W.I., Yuen P.W., Fan Y.W., Lam L.K. and Wong L.Y., Outcome Analysis of Patients with Craniofacial Resection: Hong Kong Experience, Australia New Zealand Journal of Surgery. New Zealand, Royal Australasian College of Surgeons, 2005, 76: 313-317.

Yung A.W.Y., Leung C., Sze A., Khong P.L., Ho W.Y., Yuen S.M. and Fan Y.W., Clinical outcome in four patients after epilepsy surgery, The 50^th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, Children's Habilitation Institute, 16-17 September 2005. 49.

Researcher : Fu M

List of Research Outputs

Garcia-Barcelo M.M., So M.T., Lau K.C., Leon Y.Y., Yuan Z., Cai W., Lui V.C.H., Fu M., Herbrick J.A., Gutter E., Proud V., Li L., Pierre-Louis J., Aleck K., van Heurn E., Belloni E., Scherer S.W. and Tam P.K.H., Population differences in the polyalanine domain and 6 new mutations in HLXB9 in patients with Currarino syndrome, Clinical Chemistry. 2006, 52(1): 46-52.

Lui V.C.H., Fu M., Poon H.C., Sham M.H., Pachnis V., Hui C.C. and Tam P.K.H., Conditional knockout of PTC1 gene in vagal neural crest cells causes defective ENS development in mice, Development of the Enteric Nervous System: Cells, signals and genes, New York, U.S.A., 26-29 March 2006. 2006.

Researcher : Fu M

List of Research Outputs

Researcher : Ganster RW

List of Research Outputs

Lui V.C.H., Leon Y.Y., Garcia-Barcelo M.M., Ganster R.W., Chen B.L.S., Hutson J.M. and Tam P.K.H., Novel RET mutation produces a truncated RET receptor lacking the intracellular signaling domain in a 3-generation family with Hirschsprung Disease, Clinical Chemistry. 2005, 51(8): 1552-1554.

Researcher : Garcia JA

List of Research Outputs

Garcia J.A. and Tam P.K.H., Promoter SNPs regulate RET transcription in Hirschsprung's disease, Human Molecular Genetics. 2006.

Researcher : Garcia-Barcelo MM

Project Title:	Role of RET regulatory polymorphisms in Hirschsprung's disease
Investigator(s):	Garcia-Barcelo MM, Tam PKH, Ganster RW
Department:	Surgery
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2004
Completion Date:	01/2006

Abstract:

To identify and functionally test a RET susceptibility locus which may predispose to disease more than 60% of the Chinese HSCR patients and to replicate our findings in an extended sample.

Project Title:	RET regulatory polymorphisms and susceptibility to Hirschsprung's disease
Investigator(s):	Garcia-Barcelo MM, Tam PKH, Ganster RW, Sham P.C.
Department:	Surgery
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2004

Abstract:

To study the effect of the RET promoter SNPs on transcription, independently and in conjection with other 5' cis-regulatory elements; to identify the transcription factor functioning at the SNPs site; to investigate whether there is functional and/or physical interactions between PHOX2B and the RET promoter; to test our genetic observations on a larger sample of Chinese HSCR patients; to investigate whether there is association between the transmission of HSCR-susceptibility RET haplotypes and PHOX2B-associated polymorphisms in affected individuals.

Project Title:	Study of the molecular basis of anorectal malformations
Investigator(s):	Garcia-Barcelo MM, Tam PKH, Lui VCH
Department:	Surgery
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2005
Completion Date:	12/2005

Abstract:

The main objective of this project is: To evaluate the human SHH, GLI3, HOXD12, HOXD13, SALL1, HLXB9, EPHB2 genes as disease susceptibility loci for anorectal malformations. Data provided by mutant mice studies (mutant mice for these genes present with a phenotype resembling ARM) suggest that these genes are likely to be implicated in the pathology of ARM.

Project Title:	RET regulatory polymorphisms and susceptibility to Hirschsprung's disease
Investigator(s):	Garcia-Barcelo MM
Department:	Surgery
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

N/A

Project Title:	Study of the molecular basis of anorectal malformations
Investigator(s):	Garcia-Barcelo MM
Department:	Surgery
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2006

Abstract:

N/A

Project Title:	Study of the molecular basis of anorectal malformations
Investigator(s):	Garcia-Barcelo MM, Lui VCH, Yuan Z.W., Tam PKH
Department:	Surgery
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	01/2006

Abstract:

To evaluate in patients with isolated ARM and/or VACTERL those genes known to be implicated in ARM according to data provided by i)mutant mice studies and, ii) their role in syndromes that include ARM as part of their spectrum (SHH, GLI3, HOXD12, HOXD13, SALL1, HLXB9, EPHB2); to investigate the gene expression profile during the development of the anorectal region in both, normal and teratogen (ethylenethiourea, ETU)-induced ARMs rat fetuses; to evaluate the genes differentially expressed in the control and in the teratogen ARM-induced embryos as candidates for ARM in humans.

List of Research Outputs

Burzynski G., Amiel J., Antinolo G., Borrego, S., Ceccherini I., Emison E., Eng C., Fernandez R., Garcia-Barcelo M.M., Griseri P., Hofstra R., Kashuk C., Lantieri F., Lyonnet S., Tam P.K.H., Tullio-Pelet A. and West K., Chakravarti A., Differential liabilities of coding and non-coding mutations in complex disease , Annual Meeting of the American Society of Human Genetics. Salt Lake City, USA, October 25-29 2005.. 2005.

Emison E., Burzynski G., Amiel J., Borrego S., Ceccherini, I., Fernandez R., Garcia-Barcelo M.M., Griseri P., Hofstra R., Kashuk C.S., Lantieri F., Lyonnet S., Tam P.K.H., Pecina A., Tullio-Pelet and A., West K., Chakravarti A., Differential liabilities of rare coding and common non-coding RET mutations explain the multifactorial genetics of Hirschsprung disease. , Gordon Research Conference on Human Genetics and Genomics Salve Regina University Newport, RI, USA, July 24-29, 2005.

Garcia-Barcelo M.M., So M.T., Lau K.C., Leon Y.Y., Yuan Z., Cai W., Lui V.C.H., Fu M., Herbrick J.A., Gutter E., Proud V., Li L., Pierre-Louis J., Aleck K., van Heurn E., Belloni E., Scherer S.W. and Tam P.K.H., Population differences in the polyalanine domain and 6 new mutations in HLXB9 in patients with Currarino syndrome, Clinical Chemistry. 2006, 52(1): 46-52.

Lau K.C., Garcia-Barcelo M.M., Leon Y.Y., So M.T., Miao X., Ngan E.S.W., Lui V.C.H., Cass D.T., Croaker G.D.H. and Tam P.K.H., Evaluation of thyroid transcription factor 1 (TTF-1) as a Hirschsprung's disease (HSCR) locus by mutation analysis, 39th Annual Meeting of the Pacific Association of Pediatric Surgeons, Taipei, Taiwan, 14-18 May 2006.

Lau K.C., Garcia-Barcelo M.M., Leon Y.Y., So M.T. and Tam P.K.H., Evaluation of thyroid transcription factor 1 (TTF-1) as a Hirschsprung's disease (HSCR) locus by mutation analysis, Development of the Enteric Nervous System: Cells, signals and genes, New York, U.S.A., 26-29 March 2006.

Lui V.C.H., Leon Y.Y., Garcia-Barcelo M.M., Ganster R.W., Chen B.L.S., Hutson J.M. and Tam P.K.H., Novel RET mutation produces a truncated RET receptor lacking the intracellular signaling domain in a 3-generation family with Hirschsprung Disease, Clinical Chemistry. 2005, 51(8): 1552-1554.

Luk J.M.C., Wang X., Garcia-Barcelo M.M., Leung P.P., Lam B.K.Y., Ho D.W.Y., Yu W.C., Hui C.K. and Lau G., Genetic polymorphisms of liver intestine-cadherin CDH17 are associated with alternative mRNA splicing and increased risk of hepatocellular carcinoma (Abstract), Hepatology. 2005, 42(4): 307A-308A Suppl 1.

Ngan E.S.W., Lui V.C.H., Lau K.C., Garcia-Barcelo M.M. and Tam P.K.H., Transcriptional profiling of eneteric neural crest cells, Mechanisms of Development. 2005, 122: S179.

Ngan E.S.W., Lui V.C.H., Lau K.C., Garcia-Barcelo M.M., Sham M.H. and Tam P.K.H., Transcriptional profiling of enteric neural crest cells, 15th International Society of Developmental Biologists Congress 2005, Sydney, Australia, 3-7 September 2005.

Researcher : He Q

Project Title:	Molecular dynamics of iron transport
Investigator(s):	He Q, Sun H
Department:	Chemistry
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	12/2002
Completion Date:	11/2006

Abstract:

(1) How the chemical properties of the critical metal-binding ligands affect iron binding and release from transferrin in vitro. (2) How a depleted level of transferrin (and iron) in living cells affects the expression of related proteins in the iron-transport pathway. (3) Study the cellular trafficking of transferrin as a possible pathway for delivering drugs and nano-particles besides iron.

Project Title:	Proteomic profiling of cellular responses to chromium (Cr) cytotoxicity
Investigator(s):	He Q
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2005
Completion Date:	03/2006

Abstract:

To study the proteomic responses of lung cells treated by chromium and correlate the proteomic results with the exist data from DNA studies.

Project Title:	Functional and structural characterization of lipoprotein MtsA in MtsABC responsible for transport of iron and other metal ions in Streptococcus pyogenes
Investigator(s):	He Q
Department:	Chemistry
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	08/2005

Abstract:

N/A

Project Title:	Proteomic approach to study metastasis of esophageal squamous cell carcinoma
Investigator(s):	He Q
Department:	Chemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2006

Abstract:

Background: Esophageal squamous cell carcinoma (ESCC) is the fourth most common malignancy and still represents a great health concern in China. Most of the patients cannot survive more than one year after presenting at healthcare centers and the 5-year survival rate for ESCC remains as low as 10 percent or even less. One of the main reasons for the ominous phenomena is that neoplasms in esophagus are not detected until they have invaded the surrounding tissues or spread throughout the body (metastasis) at advanced stages. The early detection and diagnosis of esophageal malignancy is critical for its therapy and management. Tumor metastasis is the spread of cancer cells from the original site to other parts of the body. It is a very complex and multi-step process and often referred to as a cascade. The process of metastasis formation begins with some tumor cells breaking adhesions with neighboring cells and detaching from the primary tumor. Those cells then dissolve the extracellular matrix, migrate and invade surrounding tissues, and/or travel via the circulatory system, invade, survive and proliferate at distant new sites. Metastasis is by far the leading cause of death in cancer patients including ESCC, responsible for more than 90% of all cancer mortality. Lymph node metastasis is a strong and dominant prognostic aspect for ESCC. Lymphatic invasion represents a physiological predictor of lymph node metastasis in patients with ESCC and is a factor significantly influencing overall survival rate. However, the molecular mechanism underlying the lymphatic invasion of cancer cells in ESCC is still unclear. Several proteins such as HIF-1α and VEGF family have been individually studied and their expression was reported to correlate with the depth of tumor invasion, tumor stage, venous invasion, lymphatic invasion, and lymph node metastasis. However, there is still lacking systematic data showing the molecular factors and their interactions in the process of lymphatic metastasis of ESCC. Proteomics is a systematic research approach aiming to provide the global characterization of protein expression and function under given conditions. Proteomics provides an effective methodology to globally examine the different protein expressions and protein interactions in disease. Proteomic technology has been widely used in biomarker discovery, target identification and pathogenetic studies including tumor metastasis. We have used 2D-gel based proteomics to compare the protein profiles between ESCC tumor and matched surrounding tissues and to identify differently expressed proteins in the esophageal cancer. A number of tumor-associated proteins including SCCA1, transgelin, TPM, prohibitin, PRX, aB-Cryst and MnSOD was detected with altered expressions, corresponding to a complicated multi-step process involved in the initiation, formation and progression of esophageal carcinoma (Proteomics, 2005, 5:2960-2971). However, ESCC metastasis has not been investigated by proteomic approach up today. Objectives: The main objective of this proposal is to study ESCC metastasis by proteomic technology. Using our established 2DE-based proteomics, we plan to profile and compare the proteomes and sub-fractions extracted from cultured esophageal cancer cells with one bearing proved metastatic potential. We will systematically characterize the differently expressed proteins in metastatic cells and identify the molecular factors correlated to the tumor invasion and metastasis.

List of Research Outputs

Researcher : Ho CM

List of Research Outputs

Woo P.C.Y., Tse H., Lau S.K.P., Leung K.W., Woo G.K.S., Wong M.K.M., Ho C.M. and Yuen K.Y., Alkanindiges hongkongensis sp. nov. A novel Alkanindiges species isolated from a patient with parotid abscess, Systematic and Applied Microbiology . 2005, 28: 316-322.

Researcher : Ho DWY

List of Research Outputs

Luk J.M.C., Chen L., Lam B.K.Y., Ho D.W.Y., Peng J.R., Leng X.S., Hui C.K., Lau G., Yip T.T. and Fan S.T., Comparing serum alpha-fetoprotein level and SELDI-TOF-MS profiling for diagnosis of hepatocellular carcinoma (Abstract), The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2-3 December 2005.

Luk J.M.C., Wang X., Garcia-Barcelo M.M., Leung P.P., Lam B.K.Y., Ho D.W.Y., Yu W.C., Hui C.K. and Lau G., Genetic polymorphisms of liver intestine-cadherin CDH17 are associated with alternative mRNA splicing and increased risk of hepatocellular carcinoma (Abstract), Hepatology. 2005, 42(4): 307A-308A Suppl 1.

Ng K.K.C., Lam C.M., Poon R.T.P., Shek T.W.H., Ho D.W.Y. and Fan S.T., Safety limit of large-volume hepatic radiofrequency ablation in a rat model, Archives of Surgery. 2006, 141(3): 252-258.

Tsui T.Y., Siu Y.T., Ho D.W.Y., Ma J., Lau C.K., Schlitt H.J. and Fan S.T., Heme oxygenase-1-derived carbon monoxide stimulates adenosine triphosphate generation in human hepatocyte, Biochemical and Biophysical Research Communications. 2005, 336(3): 898-902.

Yang Z., Ho D.W.Y., Lau C.K., Lam C.T., Lum C.T., Poon R.T.P. and Fan S.T., Allograft inflammatory factor-1 (AIF-1) is crucial for the survival and pro-inflammatory activity of macrophages, International Immunology. 2005, 17(11): 1391-1397.

Yang Z., Liu Y., Ho D.W.Y., Lau C.K., Poon R.T.P. and Fan S.T., Blockade of vascular endothelial growth factor (VEGF) receptor enhances the therapeutic efficacy of hypoxia and chemotherapy in hepatocellular carcinoma (Poster Presentation), The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2 - 3 December 2005.

Yang Z., Lau C.K., Ngai P.P., Ho D.W.Y., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Delayed immunosuppression induces long-term liver allograft survival through interleukin-10 (IL-10) dependent manner (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Yang Z., Lau C.K., Ngai P.P., Ho D.W.Y., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Short-term cardiotrophin-1 (CT-1) rescues marginal cirrhotic liver remnant after major hepatectomy without increasing the risk of tumor recurrence (Oral Presentation), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A92.

Yang Z., Ngai P.P., Lau C.K., Tam K.H., Ho D.W.Y., To J.Y.T., Poon R.T.P. and Fan S.T., Transient production of interleukin-10 (IL-10) by residual macrophages is crucial for the ischemia/reperfusion injury and long-term allograft survival in liver transplantation (Oral Presentation), The 8th International Congress of the Cell Transplant Society, Milan, Italy, 24 - 26 May 2006.

Researcher : Ho JCY

Project Title:	Functional characterization of Glycosyl-phosphatidylinositol (GPI) anchor attachment protein 1 (GAA1) in liver cancer
Investigator(s):	Ho JCY, Fan ST, Cheung ST
Department:	Centre for the Study of Liver Disease
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004
Completion Date:	10/2005

Abstract:

To determine the expression level of GAA1 in HCC; to elucidate the function of GAA1 in liver cancer.

List of Research Outputs

Cheung S.T., Liu C.L., Chow J.P.H., Lee Y.T., Ip Y.C., Ho J.C.Y. and Fan S.T., Preoperative plasma transcript AA454543 level is an independent prognostic factor for hepatocellular carcinoma after partial hepatectomy, The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Chua C.W., Lee D.T.W., Ling M.T., Zhou C., Man K., Ho J.C.Y., Chan F.L., Wang X. and Wong Y.C., FTY720, a fungus metabolite, inhibits in vivo growth of androgen-independent prostate cancer, International Journal of Cancer. 2005, 117: 1039-1048.

Ho J.C.Y., Cheung S.T. and Fan S.T., Novel serological marker for hepatocellular carcinoma (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Shin J.A., Choi E.S., Kim HS H.S., Ho J.C.Y., Watts F.Z., Park S.D. and Jang Y.K., SUMO modification is involved in the maintenance of heterochromatin stability in fission yeast, Molecular Cell. 2005.

Researcher : Ho JWC

Project Title:	The Hereditary Gastrointestinal Cancer Registry - a programme for the people of Hong Kong
Investigator(s):	Ho JWC, Yuen ST, Chung LP, Kwan KYM
Department:	Surgery
Source(s) of Funding:	Terry Fox Fellowship
Start Date:	06/2000

Abstract:

To achieve colorectal cancer prevention in high risk families through early detection and timely treatment; to raise awareness of hereditary colorectal cancer through education of the public and the health care profession so as to ensure proper referral of these families to our Registry for the delivery of proper preventive service; to establish support services to improve psychosocial well beings of affected individuals and their at-risk family members; to improve the understanding of hereditary colorectal cancer and its management.

List of Research Outputs

Ho J.W.C., Yuen S.T. and Lam T.H., A case-control study on environmental and familial risk factors for colorectal cancer in Hong Kong: chronic illnesses, medication and family history, Hong Kong Medical Journal. 2006, 12(suppl I): S14-16.

Ho J.W.C., Yuen S.T. and Lam T.H., A case-control study on environmental and familial risk factors for colorectal cancer in Hong Kong: dietary determinants of colorectal cancer risk, Hong Kong Medical Journal. 2006, 12(Suppl 1): S11-13.

Ho J.W.C., Yuen S.T. and Lam T.H., A case-control study on environmental and familial risk factors for colorectal cancer in Hong Kong: physical activity reduces colorectal cancer risk, Hong Kong Medical Journal. 2006, 12(suppl 1): S8-10.

Ho J.W.C., Colorectal cancer, Certificate course on cancer nursing for registered and enrolled nurse, The Hong Kong Anticancer Society, Hong Kong, 21 September 2005.

Ho J.W.C., Wei R. and Chan M.S., Hereditary colorectal cancer syndromes in Hong Kong: a Registry's perspective, Hereditary Cancer in Clinical Practice. 2005, 3(4): 147-154.

Ho J.W.C., Yuen S.T. and Lam T.H., Smoking, drinking and colorectal cancer risk - a case-control study on environmental and familial risk factors for colorectal cancer in Hong Kong., Health Services Research Fund - Research Dissemination Report. 2005, 2 pp.

Ho J.W.C., Understanding colorectal cancer and its treatment, Educational talk for patient and relatives, Cancer Centre of Queen Mary Hospital, Hong Kong, 7 September 2005.

Ho J.W.C., Update on colorectal cancer screening, Hot Topics in Gastro-Hepatology; 10th Hong Kong Medical Forum, Hong Kong, 16-17 July 2005.

Iacopetta B., Russo A., Bazan V., Dardanoni G., Gebbia N., Soussi T., Kerr D., Elsaleh H., Soong R., Kandioler D., Janschek E., Kappel S., Lung M., Leung C.S., Ko J.M., Yuen S.T., Ho J.W.C., Leung S.Y., Crapez E., Duffour J., Ychou M., Leahy D.T., O'donoghue D.P., Agnese V., Cascio S., Di Fede G., Chieco-Bianchi L., Bertorelle R., Belluco C., Giaretti W., Castagnola P., Ricevuto E., Ficorella C., Bosari S., Arizzi C.D., Miyaki M., Onda M., Kampman E., Diergaarde B., Royds J., Lothe R.A., Diep C.B., Meling G.I., Ostrowski J., Trzeciak L., Guzinska-Ustymowicz K., Zalewski B., Capella G.M., Moreno V., Peinado M.A., Lonnroth C., Lundholm K., Sun X.F., Jansson A., Bouzourene H., Hsieh L.L., Tang R., Smith D.R., Allen-Mersh T.G., Khan Z.A., Shorthouse A.J., Silverman M.L., Kato S. and Ishioka C., Functional categories of TP53 mutation in colorectal cancer: results of an International Collaborative Study, Annals of Oncology. 2006, 17(5): 842-7.

Law W.L., Choi H.K., Ho J.W.C., Lee Y.M. and Seto C.L., Outcomes of surgery for mid and distal rectal cancer in the elderly , World Journal of Surgery. 2006, 30(4): 598-604.

Ng K.K.C., Law W.L., Lee Y.M., Choi H.K., Seto C.L. and Ho J.W.C., Self-expanding metallic stent as a bridge to surgery versus emergency resection for obstructing left-sided colorectal cancer: a case-matched study, Journal of Gastrointestinal Surgery. 2006, 10(6): 798-803.

Researcher : Ho JWY

Project Title:	Study on circulating endothelial progenitor cell in hepatocellular carcinoma - potential biomarker of tumor angiogenesis and target for anti-angiogenic therapy
Investigator(s):	Ho JWY, Poon RTP, Fan ST
Department:	Centre for the Study of Liver Disease
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004
Completion Date:	04/2006

Abstract:

To assess the levels of circulating endothelial progenitor cells in hepatocellular carcinoma (HCC).

List of Research Outputs

Chua C.W., Lee D.T.W., Ling M.T., Zhou C., Man K., Ho J.W.Y., Wang X. and Wong Y.C., FTY720 and its anticancer effects on androgen independent prostate cancer: an in vivo study using CWR22R xenograft., 10th Research Postgraduate Symposium, Fac. Med, HKU. 2005, 50.

Ho J.W.Y., Man K., Sun K.W., Lee K.W., Poon R.T.P. and Fan S.T., Effects of a novel immunomodulating agent, FTY720, on tumor growth and angiogenesis in hepatocellular carcinoma, Molecular Cancer Therapeutics. 2005, 4(9): 1430-1438.

Lee K.W., Man K., Ho J.W.Y., Wang X., Poon R.T.P., Xu Y., Ng T.P., Chu A.C.Y., Sun K.W., Ng I.O.L., Sun H.C., Tang Z.Y., Xu R. and Fan S.T., FTY720: a promising agent for treatment of metastatic hepatocellular carcinoma, Clinical Cancer Research. 2005, 11(23): 8458-8466.

Man K., Zhao Y., Xu A., Lo C.M., Lam K.S., Ng K.T., Ho J.W.Y., Sun C.K. and Lee K.W., FTY720 significantly improves small-for-size fatty liver graft survival, American Journal of Transplantation. 2006, 6(3): 467-476.

Man K., Zhao Y., Xu A., Lo C.M., Lam K.S.L., Ng T.P., Ho J.W.Y., Sun K.W., Lee K.W., Li X. and Fan S.T., Fat-derived hormone adiponectin combined with FTY720 significantly improves small-for-size fatty liver graft survival, American Journal of Transplantation. 2006, 6(3): 467-476.

Man K., Su M., Ng T.P., Lo C.M., Zhao Y., Ho J.W.Y., Sun K.W., Lee K.W. and Fan S.T., Rapamycin attenuates liver graft injury in cirrhotic recipient - the significance of down-regulation of Rho-ROCK-VEGF pathway, American Journal of Transplantation. 2006, 6(4): 697-704.

Man K., Sun K.W., Liu C.L., Ng T.P., Ho J.W.Y., Poon R.T.P. and Fan S.T., The significance of cell adhesion kinase in recurrence of hepatocellular carcinoma after curative liver resection (Abstract), The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2-3 December 2005.

Researcher : Ho KL

List of Research Outputs

Leung S.Y.L., Wong B.B.W., Cheung M.C., Ho K.L., Lee F.C.W. and Tam P.C., Intrarectal administration of Iidocaine gel versus plain lubricant gel for pain control during transrectal ultrasound-guided extensive 10-core prostate biopsy in Hong Kong Chinese population: prospective double-blind randomized controlled trial, Hong Kong Medical Journal. 2006, 12(2): 103-107.

Researcher : Ho P

List of Research Outputs

Ho P., Cheng S.W.K., Ting A.C.W. and Poon J.T.C., Improvement of mortality of ruptured abdominal aortic aneurysm patients over 12 years and its relationship with tracheostomy, Annals of Vascular Surgery. 2006, 20(2): 175-182.

Ho P., Monitoring of abdominal aortic aneurysm after endovascular repair: aneurysm volume or maximal diameter?, The 34th Annual Meeting of the Japanese Society for Vascular Surgery, Tokyo, Japan, 11 May 2006.

Ho P., Yiu W.K., Cheung G.C.Y., Cheng S.W.K., Ting A.C.W. and Poon J.T.C., Systemic review of clinical trials comparing open and endovascular treatment of abdominal aortic aneurysm, Surgical Practice. 2006, 10: 24-37.

Ting A.C.W., Cheng S.W.K., Ho P., Poon J.T.C., Wong Wu L.H. and Cheung G.C.Y., Reduction in deep vein reflux after concomitant subfascial endoscopic perforating vein surgery and superficial vein ablation in advanced primary chronic venous insufficiency, Journal of Vascular Surgery. 2006, 43(3): 546-550.

Researcher : Ho WK

Project Title:	Effect of chemotherapy on cochlear function
Investigator(s):	Ho WK
Department:	Surgery
Source(s) of Funding:	Other Funding Scheme
Start Date:	06/1996

Abstract:

To assess the severity of cochlear damage in patient receiving chemotherapy for cancer.

Project Title:	Evaluation of a novel electronic device in screening for obstructive sleep syndrome in snore
Investigator(s):	Ho WK, Chung KF
Department:	Surgery
Source(s) of Funding:	Other Funding Scheme
Start Date:	03/2002

Abstract:

To evaluate the accuracy of the SleepStrip as a tool for obstructive sleep apnea screening insnorers.

Project Title:	Study of changes in upper airway pressure in patients before and after upper airway surgery for sleep-related breathing disorders: identification of levels of collapse and prediction of surgical response
Investigator(s):	Ho WK, Wei WI
Department:	Surgery
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Abstract:

To evaluate the using of multi-level pressure measurements to correlate with the result of surgical treatment.

List of Research Outputs

Ho W.K. and Wei W.I., Current Concepts of Chronic Sinusitis Management and Paranasal Sinus Surgery (in press 11/2005), Medical Progress. 2005, 564-571.

Ho W.K. and Wei W.I., Current Concepts of Chronic Sinusitis Management and Paranasal Sinus Surgery, Medical Progress. 2005, 564-571.

Ho W.K. and Ng W.M., Schwannoma of the larynx , ENT Journal. 2005, 84(9): 554-555.

Ho W.K., Lo S.D. and Ng W.M., Schwannoma of the larynx, Ear Nose Throat J. 2005, 84: 336-337.

Ho W.K., Lo S.D.C. and Ng W.M., Schwannoma of the larynx, Ear, Nose & Throat Journal. 2005, 84: 9.

Ho W.K., Treatment of Snoring, Plenary Session, Annual Scientific Meeting, the Hong Kong Society of Sleep Medicine. . 2005.

Lam P.K.Y., Ho W.K., Ho A.C., Ng W.M., Yuen P.W. and Wei W.I., Long-term performance of indwelling tracheoesophagel speaking valves in Chinese patients undergoing laryngectomy, Arch Otolaryngol Head Neck Surg. 2005, 131: 954-8.

Lam P.K.Y., Wei W.I., Hui Y. and Ho W.K., Prevalence of pH-documented laryngopharyngeal reflux in Chinese patients with clinically suspected reflux laryngitis, American Journal of Otolaryngology. Elsevier, 2006, 27: 186-189.

Lund V.J., Wei W.I. and Ho W.K., Ethnic variation in sinonasal anatomy on CT-scanning, Rhinology. 2005, 43(3): 210-214.

Wei W.I., Ferlito A., Rinaldo A., Gourin C.G., Lowry J., Ho W.K., Leemans C.R., Shaha A.R., Suarez C., Clayman G.L., Robbins K.T., Bradley P.J. and Silver C.E., Management of the N0 neck-reference or preference, Oral Oncol.. 2006, 42: 115-22.

Wei W.I., Hui Y. and Ho W.K., Prevalence of pH-documented laryngopharyngeal reflux in Chinese patients with clinically suspected reflux laryngitis (in press), Am J Otolaryngol . 2005, 186-189.

Researcher : Huang C

List of Research Outputs

Chan O.O., Chu K.M., Leung S.Y., Huang C., Sun Y.W., Ko S., Yuen R.M.F., Xia H.H.X., Cho C.H., Hui W.M., Lam S.K., Rashid A. and Wong B.C.Y., Helicobacter pylori infection, interleukin 1 beta polymorphism and predisposition to gastric cancer through the CpG island methylation pathway, Presented at 11th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong, 14 January 2006.

Chan O.O., Chu K.M., Leung S.Y., Huang C., Sun Y., Ko S., Yuen R.M.F., Xia H.H.X., Cho C.H., Hui W.M., Lam S.K., Rashid A. and Wong B.C.Y., Helicobacter pylori Infection, Interleukin 1 Beta Polymorphism and Predisposition to Gastric Cancer Through the Cpg Island Methylation, Gastroenterology. 2006, 130 (4 Suppl 2): A-717.

Researcher : Huang X

List of Research Outputs

Ren Y., Cao B., Law S.Y.K., Xie Y., Lee P.Y., Cheung C.M., Chen Y., Huang X., Chan H.M., Zhao P., Luk J.M.C., Vande Woude G. and Wong J., Hepatocyte growth factor promotes cancer cell migration and angiogenic factors expression: a prognostic marker of human esophageal squamous cell carcinomas, Clinical Cancer Research. 2005, 11(17): 6190-6197.

Ren Y., Law S.Y.K., Huang X., Lee P.Y., Bacher M., Srivastava G. and Wong J., Macrophage migration inhibitory factor stimulates angiogenic factor expression and correlates with differentiation and lymph node status in patients with esophageal squamous cell carcinoma, Annals of Surgery. 2005, 242(1): 55-63.

Researcher : Hui Y

List of Research Outputs

Au D.K.K., Lam B.C.C., Young B.W.Y., Yeung W. and Hui Y., AABR results on universal newborn hearing screening programme in Hong Kong, Poster Presentation, 4th Widex Congress of Paediatric Audiology, Canada. 2005.

Au D.K.K., Hui Y., Hao J. and Wei W.I., Electrode Insertion Depth on Cantonese Tone Perception in Hong Kong Cochlear Implant Users, Proceedings, 5th Asia Pacific Symposium on Cochlear Implant and Related Sciences, Hong Kong. 2005, 97.

Chu K.M.Y., Au D.K.K., Hui Y., Chow C.K. and Wei W.I., Short electrode insertion in cochlear implantation: speech perception performance of Cantonese-speaking subjects., Arta Otolaryngol. 2005, 125: 718-724.

Hui Y., Pediatric ENT emergencies, Postgraduate Diploma in child and Adolescent Medicine Module 4: paediatric emergencies. Organized by the Department of Pediatrics and Adolescent Medicine, University of Hong Kong, July 16, 2005. 2005.

Hui Y. and Au D.K.K., Revision cochlear implant, Proceedings, Advances in Deafness Management, Hong Kong. 2005, 55-56.

Hui Y., Au D.K.K. and Chow C.K., The use of BAHA for single sided deafness, Proceedings, Advances in Deafness Management, Hong Kong. 2005, 57-58.

Hui Y., bone Anchored hearing aid, Hong Kong Society for the Deaf July 2, 2005. 2005.

Lam B.C.C., Tsao Y.C. and Hui Y., Clinical Practice Guideline on the Diagnosis and Management of Acute Otitis Media, Hong Kong Journal of Paediatrics. 2006, 11(1): 76-83.

Lam P.K.Y., Wei W.I., Hui Y. and Ho W.K., Prevalence of pH-documented laryngopharyngeal reflux in Chinese patients with clinically suspected reflux laryngitis, American Journal of Otolaryngology. Elsevier, 2006, 27: 186-189.

Ng P.K., Hui Y., Lam B.C.C., Goh W.H.S. and Yeung C.Y., Feasibility of implementing a universal neonatal hearing screening program by dpoae detection at a university hospital in Hong Kong, The 50^th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, Children's Habilitation Institute, 16-17 September 2005. 41.

Wei W.I., Hui Y. and Ho W.K., Prevalence of pH-documented laryngopharyngeal reflux in Chinese patients with clinically suspected reflux laryngitis (in press), Am J Otolaryngol . 2005, 186-189.

Researcher : Hung KN

List of Research Outputs

Au W.Y., Hung K.N., Shek T.W.H. and Ma E.S.K., Side effects related to cancer treatment: CASE 3. Primary cerebral lymphoma after radiotherapy for recurrent meningioma, Journal of Clinical Oncology. 2005, 23(33): 8535-6.

Lee T.M.C., Liu H.L., Hung K.N., Pu J., Ng Y.B., Mak K.Y., Gao J.H. and Chan C.C.H., The cerebellum’s involvement in the judgment of spatial orientation: a functional magnetic resonance imaging study, Neuropsychologia. 2005, 43: 1870-1877.

Researcher : Ip YC

List of Research Outputs

Cheung S.T., Liu C.L., Chow J.P.H., Lee Y.T., Ip Y.C., Ho J.C.Y. and Fan S.T., Preoperative plasma transcript AA454543 level is an independent prognostic factor for hepatocellular carcinoma after partial hepatectomy, The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Ip Y.C., Cheung S.T. and Fan S.T., MT1-MMP in relation to metastasis of hepatocellular carcinoma (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Ip Y.C., Cheung S.T., Leung K.L. and Fan S.T., Mechanism of metastasis by membrane type 1-matrix metalloproteinase in hepatocellular carcinoma, World Journal of Gastroenterology. 2005, 11(40): 6269-6276.

Researcher : Jiang G

List of Research Outputs

Ren Y., Chan H.M., Fan J., Xie Y., Chen Y., Li W., Jiang G., Liu Q., Meinhardt A. and Tam P.K.H., Inhibition of tumor growth and metastasis in vitro and in vivo by targeting macrophage migration inhibitory factor in human neuroblastoma, Oncogene. 2006, 25(25): 3501-3508.

Researcher : Kam CSK

List of Research Outputs

Ma L., Chan K.W., Trendell-Smith N.J., Wu A.Y.Y., Tian L., Lam A.C., Lo C.K., Chik S.C.C., Ko K.H., To K.W., Kam C.S.K., Li X., Yang C., Leung S.Y., Ng M.H. and Huang F., Systemic autoimmune disease induced by dendritic cells that have captured necrotic but not apoptotic cells in susceptible mouse strains, In: Ma L, Chan KW, Trendell-Smith NJ, Wu A, Tian L, Lam AC, Chan AK, Lo CK, Chik S, Ko KH, To CK, Kam SK, Li XS, Yang CH, Leung SY, Ng MH, Stott DI, MacPherson GG, Huang FP, European Journal of Immunology (In This Issue highlight, Editorial Comments). 2005, 35(11): 3364-75.

Researcher : Kim M

List of Research Outputs

Hui C.K., Lau E., Monto A., Kim M., Luk J.M.C., Poon R.T.P., Leung N., Lo C.M., Fan S.T. and Lau G., Natural history of patients with recurrent chronic hepatitis C virus and occult hepatitis B co-infection after liver transplanation, AM J Transplanation. 2006, 6(7): 1600-8.

Researcher : Ko S

List of Research Outputs

Chan O.O., Chu K.M., Leung S.Y., Huang C., Sun Y.W., Ko S., Yuen R.M.F., Xia H.H.X., Cho C.H., Hui W.M., Lam S.K., Rashid A. and Wong B.C.Y., Helicobacter pylori infection, interleukin 1 beta polymorphism and predisposition to gastric cancer through the CpG island methylation pathway, Presented at 11th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong, 14 January 2006.

Chan O.O., Chu K.M., Leung S.Y., Huang C., Sun Y., Ko S., Yuen R.M.F., Xia H.H.X., Cho C.H., Hui W.M., Lam S.K., Rashid A. and Wong B.C.Y., Helicobacter pylori Infection, Interleukin 1 Beta Polymorphism and Predisposition to Gastric Cancer Through the Cpg Island Methylation, Gastroenterology. 2006, 130 (4 Suppl 2): A-717.

Researcher : Kok TW

List of Research Outputs

Liu Y., Poon R.T.P., Qian X.M., Li L., Lau C.P.Y., Chen Y.J., Kok T.W. and Fan S.T., A study of the effect of vascular endothelial growth factor tyrosine kinase inhibitor PTK 787/ZK222584 on liver fibrosis (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Researcher : Lam BKY

List of Research Outputs

Chan S.C., Liu C.L., Lo C.M., Lam B.K.Y., Lee E.W.M., Wong Y. and Fan S.T., Estimating liver weight of adults by body weight and gender, World Journal of Gastroenterology. 2006, 12(14): 2217-2222.

Luk J.M.C., Chen L., Lam B.K.Y., Ho D.W.Y., Peng J.R., Leng X.S., Hui C.K., Lau G., Yip T.T. and Fan S.T., Comparing serum alpha-fetoprotein level and SELDI-TOF-MS profiling for diagnosis of hepatocellular carcinoma (Abstract), The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2-3 December 2005.

Luk J.M.C., Wang X., Garcia-Barcelo M.M., Leung P.P., Lam B.K.Y., Ho D.W.Y., Yu W.C., Hui C.K. and Lau G., Genetic polymorphisms of liver intestine-cadherin CDH17 are associated with alternative mRNA splicing and increased risk of hepatocellular carcinoma (Abstract), Hepatology. 2005, 42(4): 307A-308A Suppl 1.

Researcher : Lam BYH

List of Research Outputs

Luk J.M.C., Lam C.T., Siu A.F.M., Lam B.Y.H., Ng I.O.L., Hu M.Y., Che C.M. and Fan S.T., Proteomic profiling of hepatocellular carcinoma in Chinese cohort reveals heat-shock proteins (Hsp27, Hsp70, GRP78) up-regulation and their associated prognostic values, Proteomics . 2006, 6(3): 1049-1057.

Researcher : Lam CM

List of Research Outputs

Lam C.M., Yong J.L., Chan O.O., Ng K.K.C., Poon R.T.P., Liu C.L., Lo C.M. and Fan S.T., Better survival in female patients with hepatocellular carcinoma: oral contraceptive pills related?, Journal of Clinical Gastroenterology. 2005, 39(6): 533-539.

Lam C.M., Yuen A.W.C., Chik B., Wai A.C. and Fan S.T., Variation in the use of laparoscopic cholecystectomy for acute cholecystitis: a population-based study, Archives of Surgery. 2005, 140(11): 1084-1088.

Law W.L., Lam C.M. and Lee Y.M., Evaluation of outcome of laparoscopic colorectal resection with POSSUM, Portsmouth POSSUM and colorectal POSSUM, The British Journal of Surgery. 2006, 93(1): 94-99.

Liu C.L., Fan S.T., Lo C.M., Tso W.K., Wong Y., Poon R.T.P., Lam C.M., Wong B.C.Y. and Wong J., Clinicobiochemical prediction of biliary cause of acute pancreatitis in the era of endoscopic ultrasonography, Alimentary Pharmacology and Therapeutics. 2005, 22(5): 423-431.

Liu C.L., Fan S.T., Lo C.M., Tso W.K., Wong Y., Poon R.T.P., Lam C.M., Wong B.C.Y. and Wong J., Comparison of early endoscopic ultrasonography and endoscopic retrograde cholangiopancreatography in the management of acute biliary pancreatitis: a prospective randomized study, Clinical Gastroenterology and Hepatology. 2005, 3(12): 1238-1244.

Ng K.K.C., Poon R.T.P., Lam C.M., Yuen J.H.F., Tso W.K. and Fan S.T., Efficacy and safety of radiofrequency ablation for perivascular hepatocellular carcinoma without hepatic inflow occlusion, British Journal of Surgery. 2006, 93(4): 440-447.

Ng K.K.C., Lam C.M., Poon R.T.P., Shek T.W.H., Ho D.W.Y. and Fan S.T., Safety limit of large-volume hepatic radiofrequency ablation in a rat model, Archives of Surgery. 2006, 141(3): 252-258.

Ng K.K.C., Poon R.T.P., Lo C.M., Liu C.L., Lam C.M. and Fan S.T., Survival analysis of patients with transplantable recurrent hepatocellular carcinoma: an implication for salvage liver transplantation (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Yong J.L., Law W.L., Lo C.Y. and Lam C.M., A comparative study of routine laparoscopic versus open appendectomy, Journal of the Society of Laparoendoscopic Surgeons. 2006, 10(2): 188-192.

Researcher : Lam CT

List of Research Outputs

Luk J.M.C., Lam C.T., Siu A.F.M., Lam B.Y.H., Ng I.O.L., Hu M.Y., Che C.M. and Fan S.T., Proteomic profiling of hepatocellular carcinoma in Chinese cohort reveals heat-shock proteins (Hsp27, Hsp70, GRP78) up-regulation and their associated prognostic values, Proteomics . 2006, 6(3): 1049-1057.

Yang Z., Ho D.W.Y., Lau C.K., Lam C.T., Lum C.T., Poon R.T.P. and Fan S.T., Allograft inflammatory factor-1 (AIF-1) is crucial for the survival and pro-inflammatory activity of macrophages, International Immunology. 2005, 17(11): 1391-1397.

Yang Z., Lau C.K., Ngai P.P., Ho D.W.Y., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Delayed immunosuppression induces long-term liver allograft survival through interleukin-10 (IL-10) dependent manner (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Yang Z., Lau C.K., Ngai P.P., Ho D.W.Y., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Short-term cardiotrophin-1 (CT-1) rescues marginal cirrhotic liver remnant after major hepatectomy without increasing the risk of tumor recurrence (Oral Presentation), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A92.

Researcher : Lam LK

List of Research Outputs

Lam L.K., Basal cell carcinoma: pitfalls and surgical treatment, Reconstruction and Rehabilitation in Head and Neck Surgery - Pedicle Flaps, Hong Kong June 2005.

Wei W.I., Yuen P.W., Fan Y.W., Lam L.K. and Wong L.Y., Outcome Analysis of Patients with Craniofacial Resection: Hong Kong Experience, Australia New Zealand Journal of Surgery. New Zealand, Royal Australasian College of Surgeons, 2005, 76: 313-317.

Researcher : Lam PKY

List of Research Outputs

Lam P.K.Y. and Lo C.Y., Diffuse sclerosing variant of papillary carcinoma of the thyroid: a 35 year comparative study at a single institution, Annals of Surgical Oncology. 2006, 13: 1-6.

Lam P.K.Y., Ho W.K., Ho A.C., Ng W.M., Yuen P.W. and Wei W.I., Long-term performance of indwelling tracheoesophagel speaking valves in Chinese patients undergoing laryngectomy, Arch Otolaryngol Head Neck Surg. 2005, 131: 954-8.

Lam P.K.Y., Wei W.I., Hui Y. and Ho W.K., Prevalence of pH-documented laryngopharyngeal reflux in Chinese patients with clinically suspected reflux laryngitis, American Journal of Otolaryngology. Elsevier, 2006, 27: 186-189.

Ng W.M., Lam P.K.Y. and Wong B.Y., Insertion of Provox2 voice prosthesis using the anterograde technique immediately after the secondary tracheoesophageal puncture, J Laryngol Otol. 2005, 119: 988-990.

Researcher : Lamb JR

List of Research Outputs

Cai Q., Tian L., Chen Y., Chan V.S.F., Thompson P.W., Lamb J.R. and Tam P.K.H., The effect of PPAR-gamma agonist in HUVEC activation, 30th FEBS Congress & 9th IUBMB Conference, Budapest, Hungary, 2-7 July 2005.

Li X., Tian L., Lamb J.R. and Tam P.K.H., Anti-TGF-beta prevents chronic rejection in a rat orthotopic small bowel transplantation model, 52nd Annual International Congress of British Association of Paediatric Surgeons, Dublin, Ireland, 12-15 July 2005.

Researcher : Lang HHB

List of Research Outputs

Lang H.H.B., Cancer staging for differentiated thyroid carcinoma, 2006.

Researcher : Lau CK

List of Research Outputs

Tsui T.Y., Lau C.K., Ma J., Glockzin G., Obed A., Schlitt H.J. and Fan S.T., Adeno-associated virus-mediated heme oxygenase-1 gene transfer suppresses the progression of micronodular cirrhosis in rats, World Journal of Gastroenterology. 2006, 12(13): 2016-2023.

Tsui T.Y., Siu Y.T., Ho D.W.Y., Ma J., Lau C.K., Schlitt H.J. and Fan S.T., Heme oxygenase-1-derived carbon monoxide stimulates adenosine triphosphate generation in human hepatocyte, Biochemical and Biophysical Research Communications. 2005, 336(3): 898-902.

Tsui T.Y., Lau C.K., Ma J., Wu X., Wang Y., Farkas S., Xu R., Schlitt H.J. and Fan S.T., rAAV-mediated stable expression of heme oxygenase-1 in stellate cells: a new approach to attenuate liver fibrosis in rats, Hepatology. 2005, 42(2): 335-342.

Yang Z., Ho D.W.Y., Lau C.K., Lam C.T., Lum C.T., Poon R.T.P. and Fan S.T., Allograft inflammatory factor-1 (AIF-1) is crucial for the survival and pro-inflammatory activity of macrophages, International Immunology. 2005, 17(11): 1391-1397.

Yang Z., Liu Y., Ho D.W.Y., Lau C.K., Poon R.T.P. and Fan S.T., Blockade of vascular endothelial growth factor (VEGF) receptor enhances the therapeutic efficacy of hypoxia and chemotherapy in hepatocellular carcinoma (Poster Presentation), The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2 - 3 December 2005.

Yang Z., Lau C.K., Ngai P.P., Ho D.W.Y., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Delayed immunosuppression induces long-term liver allograft survival through interleukin-10 (IL-10) dependent manner (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Yang Z., Lau C.K., Ngai P.P., Ho D.W.Y., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Short-term cardiotrophin-1 (CT-1) rescues marginal cirrhotic liver remnant after major hepatectomy without increasing the risk of tumor recurrence (Oral Presentation), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A92.

Yang Z., Ngai P.P., Lau C.K., Tam K.H., Ho D.W.Y., To J.Y.T., Poon R.T.P. and Fan S.T., Transient production of interleukin-10 (IL-10) by residual macrophages is crucial for the ischemia/reperfusion injury and long-term allograft survival in liver transplantation (Oral Presentation), The 8th International Congress of the Cell Transplant Society, Milan, Italy, 24 - 26 May 2006.

Researcher : Lau CPY

List of Research Outputs

Liu Y., Poon R.T.P., Qian X.M., Li L., Lau C.P.Y., Chen Y.J., Kok T.W. and Fan S.T., A study of the effect of vascular endothelial growth factor tyrosine kinase inhibitor PTK 787/ZK222584 on liver fibrosis (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Researcher : Lau H

List of Research Outputs

Chok K.S.H., Lau H. and Yuen W.K., Development of outpatient laparoscopic surgery in Hong Kong, Day Surgery Journal of India. 2006, 2: 29-34.

Chok K.S.H., Yuen W.K., Lau H., Lee F.C.W. and Fan S.T., Five-year experience of outpatient laparoscopic cholecystectomy in Hong Kong, Surgical Practice. 2005, 9(4): 143-146.

Lau H., 2nd Prize (by Dr. Christain Fang), Resident Paper Contest, 15th Asian Congress of Surgery in conjunction with the 30th Annual Scientific Meeting of The Royal College of Surgeons of Thailand, Pattaya, Thailand, 20-23 July 2005. 2005.

Lau H., A good paper: a reviewer's view, Research Paper Writing Workshop (HA Commissioned Training), Queen Mary Hospital, Hong Kong, 10 February 2006. 2006.

Lau H., Chairman, Free Paper (Video) Session 13: General Surgery, 7th Asia Pacific Contress of Endoscopic Surgery ELSA 2005, Minimally Invasive Surgery - Navigating into the second decade, Hong Kong, 19 August 2005. 2005.

Lau H., Chairman, Hernia Symposium, 7th Asia Pacific Congress of Endoscopic Surgery ELSA 2005, Minimally Invasive Surgery - Navigating into the second decade, Hong Kong, 18 August 2005. 2005.

Lau H., Course Director and Faculty Member, Research Paper Writing Workshop for Higher Surgical Trainees, HA Commissioned Training, Skills Development Centre, Queen Mary Hospital and CAL Laboratory, G/F., Yu Chun Keung Medical Library, Hong Kong, 10 February 2006 . 2006.

Lau H., Patil N.G. and Yuen W.K., Day-case endoscopic totally extraperitoneal inguinal hernioplasty versus open Lichtenstein hernioplasty for unilateral primary inguinal hernia in males: a randomized trial, Surgical Endoscopy. 2006, 20(1): 76-81.

Lau H., Lo C.Y., Patil N.G. and Yuen W.K., Early versus delayed-interval laparoscopic cholecystectomy for acute cholecystitis: a metaanalysis, Surgical Endoscopy. 2006, 20(1): 82-87.

Lau H., Endoscopic totally expraperitoneal inguinal hernioplasty (Invited Lecture), Advanced Laparoscopic Surgery Course, Queen Mary Hospital, Hong Kong, 28-29 April 2006. 2006.

Lau H., Endoscopic totally extraperitoneal inguinal hernioplasty (Invited live demonstration), 7th Asia Pacific Congress of Endoscopic Surgery ELSA 2005, Minimally Invasive Surgery - Navigating into the second decade, Hong Kong, 17-19 August 2005. 2005.

Lau H., Endoscopic totally extraperitoneal inguinal hernioplasty (Invited live demonstration), Hernia Repair Live Demo day, Minimally Invasive Surgery Centre, Kwong Wah Hospital, Hong Kong, 29 September 2005. 2005.

Lau H., Endoscopic totally extraperitoneal inguinal hernioplasty: anatomical and technical considerations (Invited), Advanced Laparoscopic Surgery Course for HST, Minimal Access Surgery Training Centre, Pamela Youde Nethersole Eastern Hospital, Hong Kong, 14-15 July 2005. 2005.

Lau H., Endoscopic totally extraperitoneal inguinal hernioplasty: anatomical and technical considerations, Advanced Laparoscopic Surgery Course for HST (2005) Manual. 2005, 2-5.

Lau H., Examiner, Mock Examination for MRCS Final Assessment & FRCS Exit Examination (jointly with Kwong Wah Hospital), Hong Kong, 17 September 2005. 2005.

Lau H., Examiner, Mock Examination for MRCS Final Assessment & FRCS Exit Examination, Hong Kong, 21 January 2006. 2006.

Lau H., Examiner, Mock Examination for MRCS Final Assessment & FRCS Exit Examination, Hong Kong, 6 August 2005. 2005.

Lau H., Examiner, Preparatory Course for The Exit Examination, Tuen Mun Hospital, Hong Kong, 30 August 2005. 2005.

Lau H., Fabrin sealant versus mechanical stapling for mesh fixation during endoscopic extraperitoneal inguinal hernioplasty (Invited), 3rd International Hernia Congress, Boston, U.S.A., 8-11 June 2006.

Lau H., Faculty Member, Basic Laparoscopic Surgery Course, Pamela Youde Nethersole Eastern Hospital, 9-10 November 2005. 2005.

Lau H., Faculty Member, Advanced Laparoscopic Surgery Course for HST, Minimal Access Surgery Training Centre, Pamela Youde Nethersole Eastern Hospital, Hong Kong, 14 - 15 July 2005. 2005.

Lau H., Fellow (1995 - present), The Hong Kong College of Surgeons. 2006.

Lau H., Fellow (1995 - present), The Royal College of Surgeons of Edinburgh. 2006.

Lau H., Fellow (1998- - present), The Hong Kong Academy of Medicine. 2006.

Lau H., Fellow (1999 - present), The Royal of Australasian College of Surgeons. 2006.

Lau H., Fellow (2000 - present), Hong Kong Society of Gastroenterology. 2006.

Lau H., Fibrin sealant versus mechanical stapling for mesh fixation during endoscopic extraperitoneal inguinal hernioplasty: a randomized prospective trial, Annals of Surgery. 2005, 242(5): 670-675.

Lau H., Hernia (Invited Lecture), Recent advances in minimal access surgery: laparoscopy, endosurgery & interventional therapy, Hospital Authority, Hong Kong, 4 May 2006. 2006.

Lau H., Patil N.G. and Yuen W.K., Is endoscopic totally extraperitoneal hernioplasty justified for the repair for groin hernia in female patients?, Surgical Endoscopy. 2005, 19(12): 1544-1548.

Lau H., Laparoscopic incisional hernia repair, The Sun, 19 April 2006. 2006, A26.

Lau H., Laparoscopic treatment of perforated peptic ulcer (Invited), International Surgical Week ISW 2005, 41st World Congress of Surgery of ISS/SIC, jointly organized with the Association of Surgeons of South Africa ASSA, Durban, South Africa, 21-25 August 2005.

Lau H., Life Member (2000 - present), Endoscopic and Laparoscopic Surgeons of Asia (ELSA). 2006.

Lau H., Member (1992 - present), Hong Kong Medical Association. 2006.

Lau H., Member (1993 - present), Public Doctor Association, Hong Kong. 2006.

Lau H., Member (1996 - present), Asian Surgical Association (ASA). 2006.

Lau H., Member (1997 - present), Society for Surgery of the Alimentary Tract (SSAT). 2006.

Lau H., Member (1998 - present), Hong Kong Society of Digestive Endoscopy. 2006.

Lau H., Member (1998 - present), International Society of Surgery (ISS)/Societe Internationale de Chirurgie (SIC). 2006.

Lau H., Member (1999 - present), American Hernia Society (AHS). 2006.

Lau H., Member (1999 - present), Audit Committe, Tung Wah Hospital. 2006.

Lau H., Member (1999 - present), Hong Kong Society of Minimal Access Surgery. 2006.

Lau H., Member (1999 - present), Hospital Comunication Committee, Tung Wah Hospital. 2006.

Lau H., Member (1999 - present), Hospital Consultative Committee, Tung Wah Hospital. 2006.

Lau H., Member (1999 - present), Hospital Transfusion Committee, Tung Wah Hospital. 2006.

Lau H., Member (1999 - present), Resuscitation committee, Tung Wah Hospital. 2006.

Lau H., Member (1999 - present), Risk Management Committee, Tung Wah Hospital. 2006.

Lau H., Member (1999 - present), Tung Wah Group of Hospitals Doctor Association. 2006.

Lau H., Member (2000 - present), Society of American Gastrointestinal Endoscopic Surgeons (SAGES). 2006.

Lau H., Member (2003 - present), Cluster Specialist Out-patient Services Subcommittee, Hong Kong West Cluster, Hospital Authority. 2006.

Lau H., Member (2003 - present), Pathology Services Sub-Committee, Hong Kong West Cluster, Hospital Authority. 2006.

Lau H., Member (2004 - present), Committee for Coordination of Minimal Access Surgery Training, Hospital Authority. 2006.

Lau H., Member (2004 - present), International Society for Digestive Surgery. 2006.

Lau H., Member (2005-2006), Editorial Board of Journals, Cutting Edge, College of Surgeons of Hong Kong. 2006.

Lau H., Mesh fixation during endoscopic inguinal hernioplasty: staples versus glue (Invited), Hong Kong Surgical Forum, Hong Kong, 13-14 January 2006.

Lau H., Organizer, Advanced Laparoscopic Surgery Course with Hands-on Cadaver Dissection, in collaboration with Department of Anatomy, The University of Hong Kong, Hong Kong, 28-29 April 2006. 2006.

Lau H., Outcomes of 1,000 consecutive endoscopic totally extraperitoneal inguinal hernioplasty (Invited), 7th Asia Pacific Congress of Endoscopic Surgery ELSA 2005, Minimally Invasive Surgery - Navigating into the second decade, Hong Kong, 17-19 August 2005.

Lau H., Review of laparoscopic hernioplasty (Invited), Hernia Repair Live Demo Day, Minimally Invasive Surgery Centre, Wah Hospital, 29 September 2005. 2005.

Lau H., Reviewer, Asian Journal of Surgery. 2005.

Lau H., Reviewer, BMC Surgery. 2006.

Lau H., Reviewer, European Journal of Gasteroenterology and Hepatology. 2006.

Lau H., Reviewer, Hong Kong Medical Journal. 2006.

Lau H., Reviewer, Surgical Practice. 2006.

Lau H., Reviewer, Surgical Practice. 2005.

Lau H. and Yuen W.K., Trauma: a multi-disciplinary sub-specialty (Editorial), Surgical Practice. 2005, 9(4): 115.

Lau H., Tutor, Intercollegiate Basic Surgical Skills Course, Royal College of Surgeons of Edinburgh & Hong Kong Collegeo of Surgeons, Princess Margaret Hospital, 1 March 2006. 2006.

Lau H., Tutor, Intercollegiate Basic Surgical Skills Course, Princess Margaret Hospital, Hong Kong, 1 March 2006. 2006.

Lau H., Tutor, Intercollegiate Basic Surgical Skills Course, Princess Margaret Hospital, Hong Kong, 14 September 2005. 2005.

Lau H., 應用高嵌體伸展聚四氟乙烯二元網的腹腔鏡前腹壁疝根治術 (Invited), 中華醫學會第十五次全國外科學術會議, 中國山東, 2005年10月27日至30日, 中國山東, 2005.

Researcher : Lau KC

List of Research Outputs

Garcia-Barcelo M.M., So M.T., Lau K.C., Leon Y.Y., Yuan Z., Cai W., Lui V.C.H., Fu M., Herbrick J.A., Gutter E., Proud V., Li L., Pierre-Louis J., Aleck K., van Heurn E., Belloni E., Scherer S.W. and Tam P.K.H., Population differences in the polyalanine domain and 6 new mutations in HLXB9 in patients with Currarino syndrome, Clinical Chemistry. 2006, 52(1): 46-52.

Lau K.C., Garcia-Barcelo M.M., Leon Y.Y., So M.T., Miao X., Ngan E.S.W., Lui V.C.H., Cass D.T., Croaker G.D.H. and Tam P.K.H., Evaluation of thyroid transcription factor 1 (TTF-1) as a Hirschsprung's disease (HSCR) locus by mutation analysis, 39th Annual Meeting of the Pacific Association of Pediatric Surgeons, Taipei, Taiwan, 14-18 May 2006.

Lau K.C., Garcia-Barcelo M.M., Leon Y.Y., So M.T. and Tam P.K.H., Evaluation of thyroid transcription factor 1 (TTF-1) as a Hirschsprung's disease (HSCR) locus by mutation analysis, Development of the Enteric Nervous System: Cells, signals and genes, New York, U.S.A., 26-29 March 2006.

Ngan E.S.W., Lui V.C.H., Lau K.C., Garcia-Barcelo M.M. and Tam P.K.H., Transcriptional profiling of eneteric neural crest cells, Mechanisms of Development. 2005, 122: S179.

Ngan E.S.W., Lui V.C.H., Lau K.C., Garcia-Barcelo M.M., Sham M.H. and Tam P.K.H., Transcriptional profiling of enteric neural crest cells, 15th International Society of Developmental Biologists Congress 2005, Sydney, Australia, 3-7 September 2005.

Researcher : Law SYK

Project Title:	The use of combined Lutetium Oxyorthosilicate (LSO) Positron Emission Scan and CT scan in staging of esophageal cancer.
Investigator(s):	Law SYK, Sham JST, Ooi CGC, Kwong DLW, Wong J, Yau Y.Y., Yeung A.
Department:	Surgery
Source(s) of Funding:	Other Funding Scheme
Start Date:	03/2002

Abstract:

To analysis the use of combined Lutetium Oxyorthosilicate (LSO) Positron Emission Scan and CT scan in staging of esophageal cancer.

Project Title:	Potential Roles of RON and Its Ligand Macrophage Stimulating Protein (MSP) as Prognostic Markers in Esophageal Squamous Cell Carcinoma (ESCC)
Investigator(s):	Law SYK, Luk JMC
Department:	Surgery
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2006

Abstract:

Esophageal cancer is the sixth most frequent cause of cancer death in the world. Esophageal squamous cell carcinoma (ESCC) is the commonest histological cell type in Asia and in Hong Kong. Advances in operative techniques and peri-operative care have made esophagectomy a safe procedure in specialized centers. In spite of this and recent advances in multimodality treatments including chemotherapy and radiotherapy, the prognosis of patients with esophageal cancer remains poor because of late diagnosis, the propensity of early spread of disease, and its occurrence in a group of elderly patients with co-morbid illnesses. The identification of a sensitive and specific disease marker is important for prognostication and to guide appropriate treatment. RON (Récepteur d’Origine Nantais) is a 185kDa tyrosine kinase receptor in the MET family. It is a transmembrane protein consists of a 150kDa β-subunit and a 40kDa α-subunit which are disulfide-linked. The receptor is normally expressed on epithelial cells, macrophages, bone marrow stem cells, and osteoclasts. It mediates a broad range of biological activities including cell proliferation, cellular adhesion, invasion, motility, metastasis, epithelial to mesenchymal transition, and inhibitions of apoptosis as well as anoikis. Many of these processes are involved in carcinogenesis. Binding of RON to its ligand macrophage stimulating protein (MSP) leads to tyrosine phosphorylation of the receptor and subsequent signal transduction, such as the focal adhesion kinase (FAK) and PI3-K/Akt or Ras signaling pathways (1). MSP belongs to the plasminogen-related kringle protein family. Inactive 78kDa single-chain pro-MSP is synthesized in hepatocytes and secreted into the circulating blood. Cleavage and activation of pro-MSP in the extravascular compartments result in the formation of disulfide-linked 53kDa α chain and 25kDa β chain, which contains the kringle domains and serine protease domain respectively. MSP was recently named hepatocyte growth factor (HGF)-like protein because of its up to 45% homology to HGF (2). We have shown that serum level of HGF correlates with tumor stage and metastasis in ESCC. It may participate in tumor angiogenesis via autocrine or paracrine mechanisms. Upon binding to c-Met, HGF might play a role in promoting ESCC cell invasion, migration and tumour metastasis. Normal epithelial cells are not affected (3). We hypothesize that MSP could be detected in serum and it may have a prognostic value in ESCC. Currently, commercially available MSP antibody is not well established for the specific detection of the MSP antigen. None has been shown to be efficient and reliable. The first objective of the present proposal is to establish specific monoclonal antibodies against MSP for developing immunoassay(s) for measurement of MSP serum levels in normal subjects and ESCC patients in order to evaluate the potential usefulness of MSP as a prognostic marker. RON, together with c-Met, which is a proto-oncogene, are the only MET family members that exist in humans (4). c-Met is a receptor for hepatocyte growth factor (HGF), and is found in high levels in esophageal tumour cells (3). Co-expression of RON and c-Met has been observed in node-negative breast cancers and ovarian cancers (5,6). Over-expression of RON alone was also found to associate with tumor development and metastasis. RON over-expression and constitutive activation were observed in breast cancer, lung cancer, ovarian carcinomas, colorectal adenocarcinomas, and hepatocellular carcinomas (6-11). The increased expression of RON on cell surface favors homodimerization and receptor activation which is sufficient to induce subsequent signal transductions. Persistent RON expression and activation leading to the loss of epithelial phenotypes also correlates with cancer cells’ abilities to invade and migrate (12). In addition to the wild-type RON, splicing variants (RONΔ165, RONΔ160, RONΔ155) were detected in various malignancies including colon and gastric cancers. All the variants have the ability to induce cell scatter in a ligand-independent way (9). We hypothesize that dysregulated RON or its splicing variants’ expressions might be involved in tumorigenesis and metastasis in ESCC in a similar manner to that of c-Met, and has a potential role as a disease and prognostic marker in ESCC. Thus, the second objective of the present study is to assess the expression of RON and its variants in patients with ESCC and to correlate their levels with clinicopathological data. References: 1. Leonard EJ, Danilkovitch A. Macrophage stimulating protein. Ad Cancer Res 2000; 77: 139-67. 2. Danilkovitch-Miagkova A, Leonard EJ. Anti-apoptotic action of macrophage stimulating protein (MSP). Apoptosis 2001; 6(3): 183-90. 3. Ren Y, Cao B, Law S, et al. Hepatocyte growth factor promotes cancer cell migration and angiogenic factors expression: a prognostic marker of human esophageal squamous cell carcinomas. Clin Cancer Res 2005; 11(17): 6190-7. 4. Wang MH, Wang D, Chen YQ. Oncogenic and invasive potentials of human macrophage-stimulating protein receptor, the RON receptor tyrosine kinase. Carcinogenesis 2003; 23(8): 1291-300. 5. Lee WY, Chen HHW, Chow NH, et al. Prognostic significance of co-expression of RON and MET receptors in node-negative breast cancer patients. Clin Cancer Res 2005; 11: 2222-8. 6. Maggiora P, Lorenzato A, Fracchioli S, et al. The RON and MET oncogenes are co-expressed in human ovarian carcinomas and cooperate in activating invasiveness. Exp Cell Res 2003; 288: 382-9. 7. Maggiora P, Marchio S, Stella MC, et al. Overexpression of the RON gene in human breast carcinoma. Oncogene 1998; 16: 2927-33. 8. Willett CG, Wang MH, Emanuel RL, et al. Macrophage-stimulating protein and its receptor in non-small-cell lung tumors: Induction of receptor tyrosine phosphorylation and cell migration. Am J Respir Cell Mol Biol 1998; 18: 489-96. 9. Zhou YQ, He C, Chen YQ, et al. Altered expression of the RON receptor tyrosine kinase in primary human colorectal adenocarcinomas: generation of different splicing RON variants and their oncogenic potential. Oncogene 2003; 22: 186-97. 10. Chen YQ, Zhou YQ, Fisher JH, et al. Targeted expression of the receptor tyrosine kinase RON in distal lung epithelial cells results in multiple tumor formation: Oncogenic potential of RON in vivo. Oncogene 2002; 21: 6382-6. 11. Persons DA, Paulson RF, Loyd MR, et al. Fv2 encodes a truncated form of the Stk receptor tyrosine kinase. Nat Genet 1999; 23: 159-65. 12. Wang D, Shen Q, Chen YQ, et al. Collaborative activities of macrophage-stimulating protein and transforming growth factor-β1 in induction of epithelial to mesenchymal transition: roles of the RON receptor tyrosine kinase. Oncogene 2004; 23: 1668-80.

List of Research Outputs

Chan K.W., Lee P.Y., Lam A.K.Y., Law S.Y.K., Wong J. and Srivastava G., Clinical relevance of Fas expression in oesophageal squamous cell carcinoma, Journal of Clinical Pathology . 2006, 59(1): 101-4.

Chan K.W., Lee P.Y., Lam A.K.Y., Law S.Y.K., Wong J. and Srivastava G., Fas expression is a favorable prognostic factor in esophageal squamous cell carcinoma, The Fourth Asia-Pacific International Academy of Pathology Congress (IAP2005), 22-26 August 2005, Beijing, China. 2005.

Chan O.O., Chu K.M., Lam S.K., Cheung K.L., Law S.Y.K., Kwok K.F., Wong R.W.M., Yuen R.M.F. and Wong B.C.Y., Early prediction of tumor recurrence after curative resection of gastric carcinoma by measuring soluble E-cadherin, Cancer. 2005, 104(4): 740-6.

Cheung H.Y.S., Law S.Y.K., Wong K.H., Kwok K.F. and Wong J., Spontaneous pneumomediastinum in a scuba diver (Case Report), Hong Kong Medical Journal. 2006, 12(2): 152-153.

Fatima S., Chui C.H., Tang W.K., Hui K.S., Au H.W., Li W.Y., Wong M.M., Cheung F., Tsao G.S.W., Lam K.Y., Beh S.L., Wong J., Law S.Y.K., Srivastava G., Ho K.P., Chan A.S. and Tang J.C.O., Transforming capacity of two novel genes JS-1 and JS-2 located in chromosome 5p and their overexpression in human esophageal squamous cell carcinoma, International Journal of Molecular Medicine. 2006, 17(1): 159-170.

Ferri L.E., Law S.Y.K., Wong K.H., Kwok K.F. and Wong J., The influence of technical complications on postoperative outcome and survival after esophagectomy, Annals of Surgical Oncology. 2006, 13(4): 557-564.

Law S.Y.K., Asia's contribution to esophageal cancer surgery, The Joint Meeting of the 30th Annual Scientific Meeting of the Royal College of Surgeons of Thailand and the 15th Asian Congress of Surgery, Pattaya, Thailand, 20-23 July. 2005.

Law S.Y.K. and Wong J., Case 16: Cervical esophageal cancer, In: Khatri V.P. (eds), Clinical Scenarios in Surgery: Clinical Scenarios in Surgical Oncology . Philadelphia, USA, Lippincott Williams & Wilkins, 2006, 63-67.

Law S.Y.K. and Wong J., Case 17: Squamous cell cancer of the mid-esophagus, In: Khatri V.P. (eds), Clinical Scenarios in Surgery: Clinical Scenarios in Surgical Oncology . Philadelphia, USA, Lippincott Williams & Wilkins, 2006, 68-73.

Law S.Y.K. and Wong J., Chapter 11: Tumours of the oesophagus, In: Tjandra J.J., Clunie G.J.A., Kaye A.H, Smith J.A. (eds), Textbook of Surgery, Third Edition . Melbourne, Australia, Blackwell Publishing, 2006, 83-92.

Law S.Y.K., Chemoradiation for esophageal cancer (Abstract), 12th Hong Kong International Cancer Congress AND 2nd Annual Meeting of Centre for Cancer Research, Faculty of Medicine, The University of Hong Kong, 8-10 December. 2005.

Law S.Y.K., Chemoradiation for esophageal cancer: is there still a role for surgeons? (Abstract), 6th International Surgical Update, Department of Surgery, Royal Hospital in association with The Royal College of Surgeons Edinburgh, Sultanate of Oman, 24-26 January. 2006.

Law S.Y.K., Chemoradiation for esophageal cancer, Surgical Thoracic Tumor Board Meeting, Department of Surgery, Weill Medical College of Cornell University, New York-Presbyterian Hospital-Weill Cornell Medical Center, New York, USA, October. 2005.

Law S.Y.K., Chemoradiation for esophageal cancer, Thoracic Tumor Board Meeting, Department of Thoracic and Cardiovascular Surgery, The University of Texas M.D. Anderson Cancer Center, Houston, USA, October. 2005.

Law S.Y.K., Early squamous cell carcinoma in China: screening, surveillance and treatment options, International Surgical Week ISW 2005, Durban, South Africa, 21-25 August. 2005.

Law S.Y.K., Esophageal cancer surgery: the Asian perspective, Surgical Grand Round, Department of Surgery, Weill Medical College of Cornell University, New York-Presbyterian Hospital-Weill Cornell Medical Center, New York, USA, October. 2005.

Law S.Y.K., Laparoscopic myotomy for achalasia (video presentation), IInd National Congress & Workshop Of Indian Society Of Diseases of Esophagus (ISDE), Mumbai, India, 13-15 January. 2006.

Law S.Y.K., Lewis Tanner esophagectomy (video presentation), IInd National Congress & Workshop Of Indian Society Of Diseases of Esophagus (ISDE), Mumbai, India, 13-15 January. 2006.

Law S.Y.K., Minimizing and salvaging complications after esophagectomy (Abstract), 6th International Surgical Update, Department of Surgery, Royal Hospital in association with The Royal College of Surgeons Edinburgh, Sultanate of Oman, 24-26 January. 2006.

Law S.Y.K., Minimizing and salvaging complications after esophagectomy, Department of Surgery, Weill Medical College of Cornell University, New York-Presbyterian Hospital-Weill Cornell Medical Center, New York, USA, October. 2005.

Law S.Y.K., Kwong D.L.W., Wong K.H., Kwok K.F., Sham J.S.T. and Wong J., Neoadjuvant chemoradiation changes the relationship between pT and pN status, and their prognostic significance in esophageal cancer (Abstract), Forty-Seventh Annual Meeting of The Society for Surgery of the Alimentary Tract (DDW), Los Angeles, 20-24 May. 2006.

Law S.Y.K., Oesophageal Surgery, Post-registration Certificate Course in Perioperative Nursing, Hospital Authority, Hong Kong, 11 March. 2006.

Law S.Y.K., Prevention and management of complications in esophageal surgery for cancer, IInd National Congress & Workshop Of Indian Society Of Diseases of Esophagus (ISDE), Mumbai, India, 13-15 January. 2006.

Law S.Y.K., Technical aspects of esophagectomy, prevention and management of complications after esophagectomy, Symposium on Minimally Invasive Techniques and Complications in the Treatment of Esophageal Diseases, Lublin, Poland, 26 April. 2006.

Law S.Y.K., Kwong D.L.W., Wong K.H., Kwok K.F., Sham J.S.T. and Wong J., The effects of neoadjuvant chemoradiation on the relationship between PT and PN status, and their prognostic significance in esophageal cancer (Poster Abstract), 10th World Congress of the International Society for Diseases of the Esophagus ISDE, Adelaide, Australia, 22-25 February. 2006.

Law S.Y.K., The esophageal anastomosis (video presentation), IInd National Congress & Workshop Of Indian Society Of Diseases of Esophagus (ISDE), Mumbai, India, 13-15 January. 2006.

Law S.Y.K., Two Field lymphadenectomy (Workshop), 10th World Congress of the International Society for Diseases of the Esophagus ISDE, Adelaide, Australia, 22-25 February. 2006.

Lo P.H., Leung A.C., Kwok C.Y., Cheung W.S., Ko J.M., Yang L.C., Law S.Y.K., Wang L.D., Li J., Stanbridge E.J., Srivastava G., Tang J.C.O., Tsao G.S.W. and Lung M.L., Identification of a tumor suppressive critical region mapping to 3p14.2 in esophageal squamous cell carcinoma and studies of a candidate tumor suppressor gene, ADAMTS9, Oncogene. 2006.

Lo P.H.Y., Leung A.C.C., Xiong W., Law S.Y.K., Duh F.M., Lerman M.I., Stanbridge E.J. and Lung M.L., Expression of candidate chromosome 3p21.3 tumor suppressor genes and down-regulation of BLU in some esophageal squamous cell carcinomas, Cancer Letters. 2006, 234(2): 184-192.

Ren Y., Cao B., Law S.Y.K., Xie Y., Lee P.Y., Cheung C.M., Chen Y., Huang X., Chan H.M., Zhao P., Luk J.M.C., Vande Woude G. and Wong J., Hepatocyte growth factor promotes cancer cell migration and angiogenic factors expression: a prognostic marker of human esophageal squamous cell carcinomas, Clinical Cancer Research. 2005, 11(17): 6190-6197.

Ren Y., Law S.Y.K., Huang X., Lee P.Y., Bacher M., Srivastava G. and Wong J., Macrophage migration inhibitory factor stimulates angiogenic factor expression and correlates with differentiation and lymph node status in patients with esophageal squamous cell carcinoma, Annals of Surgery. 2005, 242(1): 55-63.

Tang W.K., Fatima S., Chui C.H., Ou T.M., Hui K.S., Wong M.M., Wong J., Law S.Y.K., Tsao G.S.W., Lam A.K.Y., Beh S.L., Srivastava G., Ho K.P. and Tang J.C.O., Oncogenic properties of a novel gene located in chromosome 5p and its overexpression in human esophageal squamous cell carcinoma, Proceedings of the 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress of Biochemistry and Molecular Biology, Kyoto, Japan, June 18-23, 2006.

Tong M., Hung W.K., Law S.Y.K., Wong K.H., Kwok K.F. and Wong J., Esophageal hematoma (Case Report), Diseases of the Esophagus. 2006, 19(3): 200-202.

Wong J. and Law S.Y.K., Anastomotic stricture following esophagectomy (Seminar), 10th World Congress of the International Society for Diseases of the Esophagus ISDE, Adelaide, Australia, 22-25 February. 2006.

Wong M.L.Y., Tao Q., Fu L., Wong K.Y., Qiu G.H., Law F.B.F., Tin P.C., Cheung W.L., Lee P.Y., Tang J.C.O., Tsao G.S.W., Lam A.K.Y., Law S.Y.K., Wong J. and Srivastava G., Aberrant promoter hypermethylation and silencing of the critical 3p21 tumour suppressor gene, RASSF1A, in Chinese oesophageal squamous cell carcinoma, International Journal of Oncology. 2006, 28(3): 767-73.

Zhang H., Jin Y., Chen X., Jin C., Law S.Y.K., Tsao G.S.W. and Kwong Y.L., Cytogenetic aberrations in immortalization of esophageal epithelial cells, Cancer Genetics and Cytogenetics. 2006, 165(1): 25-35.

Researcher : Law WL

Project Title:	Self-expanding metallic stents for the poor patients with malignant colorectal obstruction
Investigator(s):	Law WL, Chu KW
Department:	Surgery
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	04/2004

Abstract:

To provide the insertion of self-expanding metallic stents to the poor patients who cannot afford the devices.

List of Research Outputs

Law W.L., Lam C.M. and Lee Y.M., Evaluation of outcome of laparoscopic colorectal resection with POSSUM, Portsmouth POSSUM and colorectal POSSUM, The British Journal of Surgery. 2006, 93(1): 94-99.

Law W.L., Laparoscopic rectal resection for cancer, Department of Surgery, University of Toronto, Toronto, Canada, 5 August 2005.

Law W.L., Laparoscopic rectal resection for cancer, Didactic Lecture, Cleveland Clinic Foundation, Cleveland, USA, 20 July 2005.

Law W.L. and Chu K.W., Outcomes of resection of stage IV rectal cancer with mesorectal excision, Journal of Surgical Oncology. 2006, 93(7): 523-528.

Law W.L., Choi H.K., Ho J.W.C., Lee Y.M. and Seto C.L., Outcomes of surgery for mid and distal rectal cancer in the elderly , World Journal of Surgery. 2006, 30(4): 598-604.

Lo S.H. and Law W.L., Laparoscopic colorectal resection for polyps not suitable for colonoscopic removal, Surgical endoscopy. 2005, 19(9): 1252-1255.

Ng K.K.C., Law W.L., Lee Y.M., Choi H.K., Seto C.L. and Ho J.W.C., Self-expanding metallic stent as a bridge to surgery versus emergency resection for obstructing left-sided colorectal cancer: a case-matched study, Journal of Gastrointestinal Surgery. 2006, 10(6): 798-803.

Yong J.L., Law W.L., Lo C.Y. and Lam C.M., A comparative study of routine laparoscopic versus open appendectomy, Journal of the Society of Laparoendoscopic Surgeons. 2006, 10(2): 188-192.

Researcher : Lee CKF

List of Research Outputs

Luk J.M.C., Wang P.P., Lee C.K.F., Wang J.H. and Fan S.T., Hepatic potential of bone marrow stromal cells: development of in vitro co-culture and intra-portal transplantation models, Journal of Immunological Methods. 2005, 305(1): 39-47.

Researcher : Lee EWM

List of Research Outputs

Chan S.C., Liu C.L., Lo C.M., Lam B.K.Y., Lee E.W.M., Wong Y. and Fan S.T., Estimating liver weight of adults by body weight and gender, World Journal of Gastroenterology. 2006, 12(14): 2217-2222.

Researcher : Lee FCW

List of Research Outputs

Chok K.S.H., Yuen W.K., Lau H., Lee F.C.W. and Fan S.T., Five-year experience of outpatient laparoscopic cholecystectomy in Hong Kong, Surgical Practice. 2005, 9(4): 143-146.

Leung S.Y.L., Wong B.B.W., Cheung M.C., Ho K.L., Lee F.C.W. and Tam P.C., Intrarectal administration of Iidocaine gel versus plain lubricant gel for pain control during transrectal ultrasound-guided extensive 10-core prostate biopsy in Hong Kong Chinese population: prospective double-blind randomized controlled trial, Hong Kong Medical Journal. 2006, 12(2): 103-107.

Researcher : Lee KW

Project Title:	Identification of novel plasma RNA biomarkers of nasopharyngeal carcinoma for early detection of cancer
Investigator(s):	Lee KW, Yuen PW, Poon Tung Ping Ronnie
Department:	Surgery
Source(s) of Funding:	Small Project Funding
Start Date:	09/2005
Completion Date:	08/2006

Abstract:

Nasopharyngeal carcinoma (NPC) occurs sporadically in the west but is endemic in southern China (25 times higher than that in the western countries) with incidence rates of between 15 and 50 per 100,000 population (Ho, Int.J.Radiat.Oncol.Biol.Phys., 1978; 4:183-205). The median survival is less than 9 months for NPC patients presenting with distant metastasis (Teo et al., Cancer, 1991;67:434-439). More than half of patients are diagnosed late due to the absence of alarming early symptoms (Chan et al., Cancer, 1998; 82: 1003-1012). The diagnosis of NPC is often difficult because of the nonspecific nature of the clinical symptoms and difficulty in visualizing the nasopharynx. Obviously, there is an urgent need to develop a more sensitive and specific diagnostic method for early detection of NPC. Advances in molecular technology have provided us with many new tools for detecting small quantity of tumor-derived nucleic acid in the blood. The presence of DNA and RNA in plasma of cancer patients has been recognized since 1970s (Leon et al., Cancer Res.,1997; 37:646-650; Shapiro , et al., Cancer, 1983;51:2116-2120), but it was not until 1989 that neoplastic characteristics of plasma DNA in cancer patients were recognized. Five years later, Sorenson et al. (Sorenson et al., Cancer Epidemiol. Biomarkers Pre., 1997;3:67-71) reported the detection of tumor-derived oncogene mutation (k-ras) in pancreatic cancer, and Vasioukhin et al. (Vasioukhin et al., Br. J. Haematol., 1994; 86:774-779) reported N-ras mutations in myelodysplastic syndrome. These striking results provide an insight for the search of tumor marker in this non-invasive diagnostic approach. In tumor associated with viral infection, viral DNA has also been detected in plasma and serum (Yu et al., Clin. Cancer Res, 2004;10:1726-1732). Similar to the development of the circulating DNA field, the earliest efforts in the detection of circulating RNA focused on the detection of tumor-derived RNA in the plasma and serum of cancer patients. In 1999, two groups simultaneously achieved this goal by detection of tumor-derived RNA in patients with NPC and melanoma (Kopreski, Clin. Cancer Res., 1999; 5:1961-1965). One of the biggest surprises in the field of circulating RNA is that such RNA species are detectable at all in plasma or serum, considering the well-known instability of RNA. One may postulate that circulating RNA is probably protected from degradation through its association with apoptotic bodies (Lo et al, Ann.N.Y.Acad.Sci., 2004;1022:135-139). A number of RNA targets have been detected in the plasma and serum of cancer patients, including, RNA species associated with the various telomerase components and, CK19 and b-catenin gene (Silva et al., Clin. Cancer Res., 2001;7: 2821-2825; Wong et al., Clin. Cancer Res., 2004:10: 1613-1617). The stability of RNA in patients’ plasma has been confirmed by our lab. With modified RNA extraction protocol, we successfully amplified genes such as 18S and CK14. Diagnostically, the stability of circulating RNA has greatly enhanced its practicality as a molecular marker. Interestingly, patients suffering from NPC have increased levels of plasma RNA, when compared with healthy individuals. Therefore, we hypothesized that alterations of genes in patients’ plasma can be detected by cDNA microarray. cDNA microarray is a useful tool for studying genetic alterations in various cancers. However, gene expression profiling for NPC patients has not been reported due to absence of normal epithelial tissue as control. Based on the observation that increased levels of plasma RNA in NPC patients, array-based approach would be feasible for identification of novel biomarker in patients’ plasma for NPC. This part of project is designed to compare the genetic alterations in NPC patients’ blood plasma and normal healthy subjects by cDNA microarray. The main objective of this study is to identify novel tumor markers in clinical samples for early detection of NPC.

List of Research Outputs

Ho J.W.Y., Man K., Sun K.W., Lee K.W., Poon R.T.P. and Fan S.T., Effects of a novel immunomodulating agent, FTY720, on tumor growth and angiogenesis in hepatocellular carcinoma, Molecular Cancer Therapeutics. 2005, 4(9): 1430-1438.

Lee K.W., Man K., Ho J.W.Y., Wang X., Poon R.T.P., Xu Y., Ng T.P., Chu A.C.Y., Sun K.W., Ng I.O.L., Sun H.C., Tang Z.Y., Xu R. and Fan S.T., FTY720: a promising agent for treatment of metastatic hepatocellular carcinoma, Clinical Cancer Research. 2005, 11(23): 8458-8466.

Lee K.W., Poon R.T.P., Tang Z.Y., Sun H.C. and Fan S.T., Identification of L1CAM as the potential biomarker for HCC metastasis (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A78.

Lee K.W., Poon R.T.P., Man K., Guan X.Y. and Fan S.T., Identification of biomarkers for metastatic hepatocellular carcinoma (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Lee K.W., Poon R.T.P. and Fan S.T., Rac activiation is associated with HCC metastasis through upregulation of VEGF in hepatocellular carcinoma (Abstract), The 97th Annual Meeting of the American Association of Cancer Research, Washington D.C., U.S.A., 1 - 5 April 2006.

Lee K.W., Young Investigators' Award 2006, Identification of LICAM as the potential biomarker for HCC metastasis, Shanghai International Liver Congress 2006, Fifth Shanghai International Symposium, Shanghai, China, 2006. 2006.

Man K., Zhao Y., Xu A., Lo C.M., Lam K.S., Ng K.T., Ho J.W.Y., Sun C.K. and Lee K.W., FTY720 significantly improves small-for-size fatty liver graft survival, American Journal of Transplantation. 2006, 6(3): 467-476.

Man K., Zhao Y., Xu A., Lo C.M., Lam K.S.L., Ng T.P., Ho J.W.Y., Sun K.W., Lee K.W., Li X. and Fan S.T., Fat-derived hormone adiponectin combined with FTY720 significantly improves small-for-size fatty liver graft survival, American Journal of Transplantation. 2006, 6(3): 467-476.

Man K., Su M., Ng T.P., Lo C.M., Zhao Y., Ho J.W.Y., Sun K.W., Lee K.W. and Fan S.T., Rapamycin attenuates liver graft injury in cirrhotic recipient - the significance of down-regulation of Rho-ROCK-VEGF pathway, American Journal of Transplantation. 2006, 6(4): 697-704.

Pang R.W.C., Poon R.T.P., Lee K.W., Fan S.T., Kwong Y.L. and Tse E.W.C., PIN1 interacts with a specific serine-proline motif of hepatitis B virus X protein to enhance hepatocarcinogenesis (Abstract), The 97th Annual Meeting of the American Association of Cancer Research, Washington D.C., U.S.A., 1 - 5 April 2006.

Poon R.T.P., Lee K.W., Yuen P.W., Ling M.T., Wang X., Wong Y.C., Guan X.Y., Man K. and Fan S.T., Id-1 promotes angiogenesis in hepatocellular carcinoma through HIF-1a-mediated VEGF upregulation (Abstract), The 97th Annual Meeting of the American Association of Cancer Research, Washington D.C., U.S.A., 1 - 5 April 2006.

Xu X., Man K., Zheng S.S., Liang T.B., Lee K.W., Ng T.P., Fan S.T. and Lo C.M., Attenuation of acute phase shear stress by somatostatin improves small-for-size liver graft survival, Liver Transplantation. 2006, 12(4): 621-627.

Zhou C., Ling M.T., Lee K.W., Man K., Wang X. and Wong Y.C., FTY720, a fungus metabolite, inhibits invasion ability of androgen-independent prostate cancer cells through inactivation of RhoA-GTPase, Cancer Letters. 2006, 233: 36-47.

Researcher : Lee KY

List of Research Outputs

Ngan E.S.W., Lee K.Y., Yeung W.S.B., Ngan H.Y.S., Ng E.H.Y. and Ho P.C., Endocrine Gland-Derived Vascular Endothelial Growth Factor is expressed in human peri-implantation endometrium, but not in endometrial carcinoma, Endocrinology. 2006, 147: 88-95.

Researcher : Lee NW

List of Research Outputs

Hui C.K., Zhang H., Lee N.W., Lu L., Leung N., Wong B.C.Y., Lo C.M., Fan S.T., Luk J.M.C. and Lau G., Upregulation of toll-like receptor 7 is essential for serological clearance of hepatitis B surface antigen in chronic hepatitis B virus (HBV) infection, Liver International 2005. 2005, Oct: 196.

Researcher : Lee PY

List of Research Outputs

Chan K.W., Lee P.Y., Lam A.K.Y., Law S.Y.K., Wong J. and Srivastava G., Clinical relevance of Fas expression in oesophageal squamous cell carcinoma, Journal of Clinical Pathology . 2006, 59(1): 101-4.

Chan K.W., Lee P.Y., Lam A.K.Y., Law S.Y.K., Wong J. and Srivastava G., Fas expression is a favorable prognostic factor in esophageal squamous cell carcinoma, The Fourth Asia-Pacific International Academy of Pathology Congress (IAP2005), 22-26 August 2005, Beijing, China. 2005.

Lee P.Y., Tong M.K., Leung P.L., Chan V.W.M., Leung S.Y.L., Tam P.C., Chan K.W., Lee C.K.F., Yeung W.S.B. and Luk J.M.C., Kidney claudin-19: Localization in distal tubules and collecting ducts and dysregulation in polycystic renal disease, FEBS Letters. 2006, 580(3): 923-31.

Lee P.Y., Leung K.W., Sham P.C., Lau G., Fan S.T. and Luk J.M.C., Proteomic expression clustering of mouse liver developmental stages (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A218.

Lin M.C., Lee P.Y., Zheng N., Yang P., Wong O.G., Kung H.F., Hui C.K., Luk J.M.C. and Lau G., Tumor necrosis factor-a-induced protein 1 and immunity to hepatitis B virus, World Journal of Gastroenterology. 2005, 11(48): 7564-8.

Ren Y., Cao B., Law S.Y.K., Xie Y., Lee P.Y., Cheung C.M., Chen Y., Huang X., Chan H.M., Zhao P., Luk J.M.C., Vande Woude G. and Wong J., Hepatocyte growth factor promotes cancer cell migration and angiogenic factors expression: a prognostic marker of human esophageal squamous cell carcinomas, Clinical Cancer Research. 2005, 11(17): 6190-6197.

Ren Y., Law S.Y.K., Huang X., Lee P.Y., Bacher M., Srivastava G. and Wong J., Macrophage migration inhibitory factor stimulates angiogenic factor expression and correlates with differentiation and lymph node status in patients with esophageal squamous cell carcinoma, Annals of Surgery. 2005, 242(1): 55-63.

Wong M.L.Y., Tao Q., Fu L., Wong K.Y., Qiu G.H., Law F.B.F., Tin P.C., Cheung W.L., Lee P.Y., Tang J.C.O., Tsao G.S.W., Lam A.K.Y., Law S.Y.K., Wong J. and Srivastava G., Aberrant promoter hypermethylation and silencing of the critical 3p21 tumour suppressor gene, RASSF1A, in Chinese oesophageal squamous cell carcinoma, International Journal of Oncology. 2006, 28(3): 767-73.

Xia W., Wong C.H., Lee P.Y., Lee W.W.M. and Cheng C.Y., Disruption Of Sertoli-germ Cell Adhesion Function In The Seminiferous Epithelium Of The Rat Testis Can Be Limited To Adherens Junctions Without Affecting The Blood-testis Barrier Integrity: An In Vivo Study Using An Androgen Suppression Model. , Journal of Cellular Physiology. 2005, 205: 141-157.

Researcher : Lee PY

Project Title:	Tight-junction claudin-19 in kidney development and renal disease
Investigator(s):	Lee PY, Luk JMC, Tam PC
Department:	Surgery
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Abstract:

To isolate, identify and characterize a novel tight-junction molecule, claudin 19, which was initially found highly expressed in kidney.

Project Title:	Molecular analysis of a novel signaling molecule VAD1.2 highly conseved in mammalian germ cells
Investigator(s):	Lee PY, Luk Dr
Department:	Surgery
Source(s) of Funding:	Small Project Funding
Start Date:	09/2005

Abstract:

Germ cells are "stem-like" cell types capable of self-renewal and differentiation into highly specialized fertilizing cell types, resulting in the formation of spermatozoa during spermatogenesis (Cheng and Mruk, 2002). Haploid germ cells are initially resided on the basal lamina of the seminiferous epithelium in the testes and they migrate towards the lumens after passing through the tight junctions for further developments and maturations (Cheng and Mruk, 2002). In this process, the cell-cell associations and dissociations, the restructurings of the junctions and their linked underlying cytoskeletons, and the regulations of gene expressions are noted. As such, different gene expression profiles can be observed at different stages of germ cell development, making it interesting to study the arrays of gene expressions. However, it will be techically difficult and tedious to isolate germ cells originated in different stages. For instance, one can manually isolate different spermatogenic stages based on their distinct transillumination properties under stereomicroscope (Chen et al, 2003; Parvinen and Vanha-Perttula, 1972). In order to simplify the procedure for the study of gene regulations in different germ cell types in the testis, vitamin A-deficiency (VAD) and post-vitamin A replenishment (PVA) rat model and differential display reverse transcription-polymerase chain reaction (RT-PCR) are used to isolate and identify stage- or cell type-specific genes in the testis (Luk et al, 2003). In this model, adult rats are first fed with vitamin A-deficient diets, which leads to the spermatogenesis arrest and subsequent germ cell depletion from the epithelium (Luk et al, 2003; Lee et al, 2004). At that time, spermatogonia and preleptotene spermatocytes are the only two germ cell types found in the seminiferous tubules (Luk et al, 2003; Lee et al, 2004). Spermatogenesis is resumed in these rats by treating them with retinol, which can stimulate the proliferative activity of spermatogonia and their development to advanced germ cell types, resulting in the synchronization of the spermatogenic stages (van Pelt and de Rooij, 1990, 1991). Testes were isolated from different post-treatment days and subjected for differential display (Luk et al, 2003). As such, a number of differentially expressed genes, such as VAD 1.2, VAD 1.3, VAD 3.4, and VAD 28, were identified (Luk et al, 2003). Among those genes, VAD 1.2 was selected for further characterization, since it was found largely in advanced germ cell types (Luk et al, 2003). Advanced germ cells take part in several important cellular processes, such as spermiogenesis and spermiation, making them as one of the most essential cell types in coordinating these processes for turning germ cells into mature spermatozoa. The production of a mature and functional spermatozoan will be a critical step for successful fertilization. As such, the understanding of genes associated with these advanced germ cells and their functions are one of the important preliminary parameters for further understanding infertility and for the development of the its diagnosis and treatment. References:Chen YM, Lee NP, Mruk DD, Lee WM, Cheng CY (2003) Fer kinase/FerT and adherens junction dynamics in the testis: an in vitro and in vivo study. Biol Reprod 69: 656-672Cheng CY, Mruk DD (2002) Cell junction dynamics in the testis: Sertoli-germ cell interactions and male contraceptive development. Physiol Rev 82: 825-874 Lee KF, Yeung WS, Chow JF, Shum CK, Luk JM (2004) Different testicular gene expression patterns in the first spermatogenic cycle of postnatal and vitamin A-deficient rat testis. Biol Reprod 70: 1010-1017Luk JM, Mok BW, Shum CK, Yeung WS, Tam PC, Tse JY, Chow JF, Woo J, Kam K, Lee KF (2003) Identification of novel genes expressed during spermatogenesis in stage-synchronized rat testes by differential display. Biochem Biophys Res Commun 307: 782-790Parvinen M, Vanha-Perttula T (1972) Identification and enzyme quantitation of the stages of the seminiferous epithelial wave in the rat. Anat Rec 174: 435-449van Pelt AM, de Rooij DG (1990) Synchronization of the seminiferous epithelium after vitamin A replacement in vitamin A-deficient mice. Biol Reprod 43: 363-367van Pelt AM, de Rooij DG (1991) Retinoic acid is able to reinitiate spermatogenesis in vitamin A-deficient rats and high replicate doses support the full development of spermatogenic cells. Endocrinology 128: 697-704

List of Research Outputs

Researcher : Lee YM

List of Research Outputs

Law W.L., Lam C.M. and Lee Y.M., Evaluation of outcome of laparoscopic colorectal resection with POSSUM, Portsmouth POSSUM and colorectal POSSUM, The British Journal of Surgery. 2006, 93(1): 94-99.

Law W.L., Choi H.K., Ho J.W.C., Lee Y.M. and Seto C.L., Outcomes of surgery for mid and distal rectal cancer in the elderly , World Journal of Surgery. 2006, 30(4): 598-604.

Ng K.K.C., Law W.L., Lee Y.M., Choi H.K., Seto C.L. and Ho J.W.C., Self-expanding metallic stent as a bridge to surgery versus emergency resection for obstructing left-sided colorectal cancer: a case-matched study, Journal of Gastrointestinal Surgery. 2006, 10(6): 798-803.

Researcher : Lee YT

List of Research Outputs

Cheung S.T., Wong S.Y., Lee Y.T. and Fan S.T., GEP upregulates wild-type p53 in hepatocellular carcinoma, Oncology Reports. 2006, 15(6): 1507-1511.

Cheung S.T., Liu C.L., Chow J.P.H., Lee Y.T., Ip Y.C., Ho J.C.Y. and Fan S.T., Preoperative plasma transcript AA454543 level is an independent prognostic factor for hepatocellular carcinoma after partial hepatectomy, The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Researcher : Leon YY

List of Research Outputs

Garcia-Barcelo M.M., So M.T., Lau K.C., Leon Y.Y., Yuan Z., Cai W., Lui V.C.H., Fu M., Herbrick J.A., Gutter E., Proud V., Li L., Pierre-Louis J., Aleck K., van Heurn E., Belloni E., Scherer S.W. and Tam P.K.H., Population differences in the polyalanine domain and 6 new mutations in HLXB9 in patients with Currarino syndrome, Clinical Chemistry. 2006, 52(1): 46-52.

Lau K.C., Garcia-Barcelo M.M., Leon Y.Y., So M.T., Miao X., Ngan E.S.W., Lui V.C.H., Cass D.T., Croaker G.D.H. and Tam P.K.H., Evaluation of thyroid transcription factor 1 (TTF-1) as a Hirschsprung's disease (HSCR) locus by mutation analysis, 39th Annual Meeting of the Pacific Association of Pediatric Surgeons, Taipei, Taiwan, 14-18 May 2006.

Lau K.C., Garcia-Barcelo M.M., Leon Y.Y., So M.T. and Tam P.K.H., Evaluation of thyroid transcription factor 1 (TTF-1) as a Hirschsprung's disease (HSCR) locus by mutation analysis, Development of the Enteric Nervous System: Cells, signals and genes, New York, U.S.A., 26-29 March 2006.

Lui V.C.H., Leon Y.Y., Garcia-Barcelo M.M., Ganster R.W., Chen B.L.S., Hutson J.M. and Tam P.K.H., Novel RET mutation produces a truncated RET receptor lacking the intracellular signaling domain in a 3-generation family with Hirschsprung Disease, Clinical Chemistry. 2005, 51(8): 1552-1554.

Researcher : Leon YY

List of Research Outputs

Researcher : Leung GKK

Project Title:	A prospective study on platelet functions in neurosurgical patients receiving acetylsalicylic acid (aspirin).
Investigator(s):	Leung GKK, Ng JKF, Fan YW
Department:	Surgery
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	12/2005

Abstract:

OBJECTIVE To assess platelet functions in hospitalized neurosurgical patients who receive aspirin immediately prior to admission. BACKGROUND Acetylsalicylic acid, or aspirin, is commonly used for the treatment of thrombotic vascular diseases such as coronary artery disease or cerebrovascular diseases. Aspirin-users may sometimes present with concurrent neurosurgical conditions, such as brain tumours and intracranial haemorrhages. Aspirin, by impairing platelet functions, may cause clinical deterioration or severe intra-operative haemorrhages in these patients. [1-2] In stable patients, it is current neurosurgical practice to withhold aspirin and to post-pone surgery until platelet functions normalize. In unstable patients, it may be necessary to proceed with immediate surgery despite impaired platelet functions. Attempts would be made in the latter situation to improve haemostasis by means of platelet transfusion. [3] Patients on aspirin, however, represent a heterogeneous population. Although the pharmacokinetics and pharmacodynamics of aspirin have been well studied, the actual clinical effect within and between individuals may vary widely due to differences in dosage, individual response, treatment duration and compliance. For an individual taking aspirin who presents with a neurosurgical condition, there is no reliable clinical method to assess platelet functions, or to ascertain if it is safe to proceed with immediate surgery, or for how long surgery should be withheld. The clinical effects of empirical corrective measures such as platelet transfusion are also unknown. Platelet functions can be assessed quantitatively using PFA-100® analyzer, which is a newly developed and validated method for the monitoring of various platelet dysfunctions. It requires venous whole blood samples only, and unlike the template bleeding-time method, PFA-100® analysis is more accurate and reproducible, and do not leave any extra scars. Actual aspirin consumption in patients who give a drug history of aspirin usage can be verified using serum thromboxaneB2 level analysis. [4-6] We therefore design this study to address the following questions, using PFA-100® and thromboxaneB2 level analysis as quantitative assessment of platelet functions and consumption: QUESTIONS TO BE ANSWERED • To what extent do PFA-100® results vary amongst patients who give history of aspirin consumption immediately prior to hospital admission? • How do PFA-100® results change after cessation of aspirin consumption? And can the changes be formulated using clinically applicable parameters such as body size, age and aspirin dosage? • To what extent does platelet transfusion alter PFA-100® results in aspirin- users. REFERENCES 1. Palmer JD, Sparrow OC, Iannotti F. Postoperative Hematoma: A 5-Year Survey and Identification of Avoidable Risk Factors. Neurosurgery 1994;36:1061-1065. 2. Stroobandt G, Fransen P, Thauvoy C, Menato hospital enetic factors in chronic subdural haematoma and causes of recurrence after drainage. Acta Neurochir (Wien) 1995;137:6-14. 3. Harder S, Klinkhardt U, Alvarez JM. Avoidance of bleeding during surgery in patients receiving anticoagulant and/or antiplatelet therapy: pharmacokinetic and pharmacodynamic considerations. Clin Pharmacokinet 2004; 43:963-981.- 4. Goh KY, Tsoi WC, Feng CS, Wickham N, Poon WS. Haemostatic changes during surgery for primary brain tumours. J Neurol Neurosurg Psychiatry 1997; 63: 334-338. 5. Favaloro EJ. Clinical application of the PFA-100. Curr Opin Hematol 2002; 9:407-415. 6. Jacoby RC, Owings JT, Holmes J, Battistella FD, Gosselin RC, Paglieroni TG. Platelet activation and function after trauma. J Trauma 2001; 51:639-647.

List of Research Outputs

Leung G.K.K., Brain metastasis [Invited lecture], Cancer Link, Hong Kong New Horizon Club, 13 August 2005. 2005.

Leung G.K.K., Brainstem death [Invited lecture], Post-registration Certificate Course on Perioperative Nursing, Institute of Advanced Nursing Studies, 16 July 2005. 2005.

Leung G.K.K. and Fan Y.W., Chronic subdural haematoma associated with arachnoid cyst in autosomal dominant polycystic kidney disease (ADPKD), Journal of Clinical Neuroscience. 2005, 12(7): 817-819.

Leung G.K.K., Auyeung K.M., Lui W.M. and Fan Y.W., Emergency placement of a self-expandable covered stent for carotid artery injury during trans-sphenoidal surgery, British Journal of Neurosurgery. 2006, 20(1): 55-57.

Leung G.K.K., Imaging in Neurosurgery [Invited lecture], Trainees in Anaesthesiology, Department of Anaesthesiology, Queen Mary Hospital, 22 July 2005. 2005.

Leung G.K.K., Membership of Editorial Board (Associate Editor), Asian Journal of Surgery. 2006.

Leung G.K.K., Outcome of head injury patients under a "Trauma-call service - a 5-year audit", 12th Annual Scientific Meeting of Hong Kong Neurosurgical Society, Hong Kong, 9 - 10 December 2005.

Leung G.K.K., Tsang W.Y., Wong C.K., Poon S.K., Boo M.S. and Tang Y.C., Protocol-directed weaning in a neurosurgical intensive care unit, Hong Kong East & West Clusters. Joint Rehabilitation Scientific Conference 05-06, 18 March 2006.

Leung G.K.K., Stem Cells - From Bench to Bedside - Neurological Application [Invited lecture], The Federation's Annual Scientific Meeting 2006, 10 June 2006. 2006.

Researcher : Leung KL

List of Research Outputs

Ip Y.C., Cheung S.T., Leung K.L. and Fan S.T., Mechanism of metastasis by membrane type 1-matrix metalloproteinase in hepatocellular carcinoma, World Journal of Gastroenterology. 2005, 11(40): 6269-6276.

Researcher : Leung KW

List of Research Outputs

Lee P.Y., Leung K.W., Sham P.C., Lau G., Fan S.T. and Luk J.M.C., Proteomic expression clustering of mouse liver developmental stages (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A218.

Researcher : Leung PL

List of Research Outputs

Lee P.Y., Tong M.K., Leung P.L., Chan V.W.M., Leung S.Y.L., Tam P.C., Chan K.W., Lee C.K.F., Yeung W.S.B. and Luk J.M.C., Kidney claudin-19: Localization in distal tubules and collecting ducts and dysregulation in polycystic renal disease, FEBS Letters. 2006, 580(3): 923-31.

Researcher : Leung SYL

List of Research Outputs

Chu T.Y., Tam P.C., Wong C.W., Wong B., Cheung M.C., Chu S.S.M. and Leung S.Y.L., Significance of testicular microlithiasis on ultrasonography findings of symptomatic men (Abstract), Surgical Practice. 2006, 10 (Suppl.): S9.

Lee P.Y., Tong M.K., Leung P.L., Chan V.W.M., Leung S.Y.L., Tam P.C., Chan K.W., Lee C.K.F., Yeung W.S.B. and Luk J.M.C., Kidney claudin-19: Localization in distal tubules and collecting ducts and dysregulation in polycystic renal disease, FEBS Letters. 2006, 580(3): 923-31.

Leung S.Y.L., Wong B.B.W., Cheung M.C., Ho K.L., Lee F.C.W. and Tam P.C., Intrarectal administration of Iidocaine gel versus plain lubricant gel for pain control during transrectal ultrasound-guided extensive 10-core prostate biopsy in Hong Kong Chinese population: prospective double-blind randomized controlled trial, Hong Kong Medical Journal. 2006, 12(2): 103-107.

Researcher : Li L

List of Research Outputs

Liu Y., Poon R.T.P., Li L., Qian X., Chen Y.J., Yang X., Sun H.C., Tang Z.Y. and Fan S.T., Synergistic inhibitory effects of PTK787/ZK222584 and interferon-alfa on hepatocellular carcinoma with metastatic potential (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25 - 28 March 2006.

Liu Y., Poon R.T.P., Li L., Qian X., Chen Y., Xu Y., Sun H.C., Tang Z.Y. and Fan S.T., Synergistic inhibitory effects of PTK787/ZK222584 and interferon-alfa on hepatocellular carcinoma with metastatic potential (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A94.

Researcher : Li W

List of Research Outputs

Ren Y., Chan H.M., Fan J., Xie Y., Chen Y., Li W., Jiang G., Liu Q., Meinhardt A. and Tam P.K.H., Inhibition of tumor growth and metastasis in vitro and in vivo by targeting macrophage migration inhibitory factor in human neuroblastoma, Oncogene. 2006, 25(25): 3501-3508.

Researcher : Li X

List of Research Outputs

Li X., Tian L., Lamb J.R. and Tam P.K.H., Anti-TGF-beta prevents chronic rejection in a rat orthotopic small bowel transplantation model, 52nd Annual International Congress of British Association of Paediatric Surgeons, Dublin, Ireland, 12-15 July 2005.

Ma L., Chan K.W., Trendell-Smith N.J., Wu A.Y.Y., Tian L., Lam A.C., Lo C.K., Chik S.C.C., Ko K.H., To K.W., Kam C.S.K., Li X., Yang C., Leung S.Y., Ng M.H. and Huang F., Systemic autoimmune disease induced by dendritic cells that have captured necrotic but not apoptotic cells in susceptible mouse strains, In: Ma L, Chan KW, Trendell-Smith NJ, Wu A, Tian L, Lam AC, Chan AK, Lo CK, Chik S, Ko KH, To CK, Kam SK, Li XS, Yang CH, Leung SY, Ng MH, Stott DI, MacPherson GG, Huang FP, European Journal of Immunology (In This Issue highlight, Editorial Comments). 2005, 35(11): 3364-75.

Man K., Zhao Y., Xu A., Lo C.M., Lam K.S.L., Ng T.P., Ho J.W.Y., Sun K.W., Lee K.W., Li X. and Fan S.T., Fat-derived hormone adiponectin combined with FTY720 significantly improves small-for-size fatty liver graft survival, American Journal of Transplantation. 2006, 6(3): 467-476.

Researcher : Li X

List of Research Outputs

Researcher : Li X

List of Research Outputs

Researcher : Lin C

Project Title:	Discovery and clinical evaluation of novel immunogenic peptides for immunotherapy of nasopharyngeal carcinoma
Investigator(s):	Lin CL, Yu WY
Department:	Surgery
Source(s) of Funding:	Innovation and Technology Support Programme
Start Date:	06/2002
Completion Date:	11/2005

Abstract:

To prepare MAP/polyepitope of the LMP1/LMP2 native peptides; to identify highly immunogenic MAPs of the LMP1/LMP2 native peptides by in vitro immunoassays and in reactivating the CTL lines from asymptomatic carriers or NPC patients; to prepare LMP1/LMP2 templated peptide libraries; to identify highly immunogenic peptides from the synthetic peptide libraries by in vitro immunoassays and in reactivating the CTL lines from asymptomatic carriers or NPC patients; to prepare MAP/polyepitope of the synthetic peptide(s) for amplification of immunogenecity; to identify novel peptide candidates for clinical studies; to formulate studies of immunogenic peptides and MAPs; to pulse the dendritic cells from NPC patents with the lead peptides/MAP, followed by intradonal injection into the patients; to evaluate tumor growth in patients with local recurrence or metastasis.

Project Title:	The role of DC-SIGN in the regulation of dendritic cell function and T cell responses: from HIV immunopathology to the induction of peripheral T cell tolerance
Investigator(s):	Lin CL, Xu S.N., Austyn J.M.
Department:	Surgery
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	11/2002

Abstract:

The project attempts to characterize the role of DC-DIGN in the regulation of dendritic cell function, and to evaluate the inhibitory effect of DC-SIGN-modulated DC on T cell responses to primary and recall antigens in vitro and in vivo. This study will provide critical insights into the molecular mechanisms whereby DC-SIGN contributes to immunosuppression or peripheral tolerance, which may allow us to design more effective strategies for antiviral therapies and the induction of transplantation tolerance.

Project Title:	The effect of SARS-associated coronavirus Spike protein on immune regulation of SARS
Investigator(s):	Lin CL, Chan VSF
Department:	Surgery
Source(s) of Funding:	VCO SARS Research Fund
Start Date:	07/2003

Abstract:

To delineate the immune regulatory mechanisms in the afferent and efferent phases of immune responses against SARS-CoV (Severe Acute Respiratory Syndrome Coronavirus) infection.

Project Title:	Development of DNA and viral vector vaccines against Epstein-Barr virus-positive nasopharyngeal carcinoma
Investigator(s):	Lin CL, Xu X.N., Austyn J.M.
Department:	Surgery
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2003

Abstract:

To design and parpare DNA vaccine encoding EBNA1 and LMP2, and the MVA vaccine encoding the cytokine GM-CSF, the chemokine RANTES, the EBV- specific lytic antigen EBNA-1, and EBV-specific latent antigen LMP2; to identify the efficacy of these vaccines in vitro on their capacity in attracting dendritic cells and also in the induction of EBNA-1 specific CD4+T cell response and LMP2-specific CTL immunity; to verify the efficacy of these vaccines in a mouse NPC and a B cell lymphoma model, including the potency of CD4+ and CTL immunity, and also to test the effect of the dosage, route, and the effect of combinational use of both the DNA and MVA vaccines.

Project Title:	Development of DNA and viral vector vaccines against Epstein-Barr virus-positive nasopharyngeal carcinoma
Investigator(s):	Lin CL, Xu X.N., Austyn J.M.
Department:	Surgery
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	09/2003

Abstract:

N/A

Project Title:	Development and clinical evaluation of peptide vaccines for immunotherapy of Epstein-Barr virus-positive nasopharyngeal carcinoma
Investigator(s):	Lin CL, Wang XN, Tam PKH, Che CM, Guo Z.H., Zeng YX, Meng MG
Department:	Surgery
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	12/2004

Abstract:

To design and prepare peptide vaccines composed of novel peptide analogues of the Epstein-Barr virus (EBV)-specific antigen latent membrane protein 2 (LMP2), EBV-specific nuclear antigen type 1 (EBNA1), the DC-specific monocyte-derived chemokine (MDC), and the dendritic cell (DC) activator CD40 ligand; to assess the efficacy of this peptide vaccine in vitro and in vivo in a NOD/SCID mouse model in terms of the capacity in attracting DCs and inducing LMP2- and EBNA1-specific T cell immunity; to conduct a phase I clinical trial to verify in vivo the efficacy of peptide vaccine in human subjects, including the safety and toxicity, the EBV-specific CD4 and CD8 T cell responsiveness, and the effect of the dosage and regimen in boosting and maintaining the longevity of effective T cell immunity.

List of Research Outputs

Researcher : Lin CL

Project Title:	Discovery and clinical evaluation of novel immunogenic peptides for immunotherapy of nasopharyngeal carcinoma
Investigator(s):	Lin CL, Yu WY
Department:	Surgery
Source(s) of Funding:	Innovation and Technology Support Programme
Start Date:	06/2002
Completion Date:	11/2005

Abstract:

Project Title:	The role of DC-SIGN in the regulation of dendritic cell function and T cell responses: from HIV immunopathology to the induction of peripheral T cell tolerance
Investigator(s):	Lin CL, Xu S.N., Austyn J.M.
Department:	Surgery
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	11/2002

Abstract:

Project Title:	The effect of SARS-associated coronavirus Spike protein on immune regulation of SARS
Investigator(s):	Lin CL, Chan VSF
Department:	Surgery
Source(s) of Funding:	VCO SARS Research Fund
Start Date:	07/2003

Abstract:

To delineate the immune regulatory mechanisms in the afferent and efferent phases of immune responses against SARS-CoV (Severe Acute Respiratory Syndrome Coronavirus) infection.

Project Title:	Development of DNA and viral vector vaccines against Epstein-Barr virus-positive nasopharyngeal carcinoma
Investigator(s):	Lin CL, Xu X.N., Austyn J.M.
Department:	Surgery
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2003

Abstract:

Project Title:	Development of DNA and viral vector vaccines against Epstein-Barr virus-positive nasopharyngeal carcinoma
Investigator(s):	Lin CL, Xu X.N., Austyn J.M.
Department:	Surgery
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	09/2003

Abstract:

N/A

Project Title:	Development and clinical evaluation of peptide vaccines for immunotherapy of Epstein-Barr virus-positive nasopharyngeal carcinoma
Investigator(s):	Lin CL, Wang XN, Tam PKH, Che CM, Guo Z.H., Zeng YX, Meng MG
Department:	Surgery
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	12/2004

Abstract:

List of Research Outputs

Chan V.S.F., Chan Y.K., Chen Y., Poon L.L.M., Cheung A.N.Y., Zheng B., Chan K.H., Mak W.W., Ngan H.Y.S., Xu X., Screaton G., Tam P.K.H., Austyn J.M., Chan L.C., Yip S.P., Peiris J.S.M., Khoo U.S. and Lin C.L., Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection. , Nature Genetics. 2006, 38: 38-46.

Khoo U.S., Chan V.S.F., Chan Y.K., Chen Y., Poon L.L.M., Cheung A.N.Y., Zheng B., Ngan H.Y.S., Tam P.K.H., Chan L.C., Yip S.P., Peiris J.S.M., Sham P.C. and Lin C.L., The protective role of homozygous L-SIGN (CLEC4M) in SARS coronavirus infection., HUGO's 11th Human Genome Meeting, Helsinki, Finland. . 2006.

Lin C.L., Donor right hepatectomy including the middle hepatic vein (Abstract), Living Donor Liver Transplantation Symposium 2006, Tokyo, Japan, 30 March 2006.

Sun R.W.Y., Chen R., Chung P.Y., Ho C.M., Lin C.L. and Che C.M., Silver nanoparticles fabricated in hepes buffer exhibit cytoprotective activities toward HIV-1 infected cells , Chemical Communications. 2005, 5059-5061.

Wong E.L.M., Sun R.W.Y., Chung P.Y., Lin C.L., Zhu N. and Che C.M., A mixed-valent ruthenium-Oxo Oxalato cluster Na₇[Ru₄(m₃-O)₄(C₂O₄)₆] with potent anti-HIV activities, Journal of the American Chemical Society. 2006, 128: 4398-4399.

Wong K.K.Y., Chung P.H.Y., Lan L.C.L., Lin C.L. and Tam P.K.H., Trends in the prevalence of Helicobacter pylori in symptomatic children in the era of eradication, Journal of Pediatric Surgery. 2005, 40: 1844-1847.

Wong S.Y., Sun R.W.Y., Chung P.Y., Lin C.L. and Che C.M., Physiologically stable vandadium (IV) porphyrins as a new class of Anti-HIV agents, Chemical Communications. 2005, 3544-3546.

Researcher : Liu CL

Project Title:	The significance of intra-graft expression profile and ultrastructural features at early phase after liver transplantation-a prospective study of liver transplantation using cadaver and live donors
Investigator(s):	Liu CL, Man K
Department:	Surgery
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Abstract:

To investigate the gene expression profiles of the donor and graft at the early phase after liver transplantation associated with hepatic ultrastructural features in liver transplantation using cadaver and live donors; to study the correlation of graft status, gene expression patterns with early and late clinical outcome functionally and morphologically.

Project Title:	Portal vein embolization before major right hepatic resection for hepatocellular carcinoma: a prospective randomized study
Investigator(s):	Liu CL
Department:	Surgery
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2006

Abstract:

N/A

Project Title:	Portal vein embolization before major right hepatic resection for hepatocellular carcinoma: a prospective randomized study
Investigator(s):	Liu CL, Fan ST, Tso WK
Department:	Surgery
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	01/2006

Abstract:

To evaluate the role of preoperative PVE in patients undergoing major right hepatic resection for HCC, and to determine whether the treatment can result in reduction of postoperative morbidities of these patients by a prospective randomized trial.

List of Research Outputs

Au W.Y., Lam C.C.K., Liu C.L. and Yuen R.M.F., Hepatitis C virus infection in adult Chinese hemophilia patients negative for the human immunodeficiency virus: treatment results with interferon and ribavirin, International Journal of Hematology. 2005, 82(3): 259-261.

Au W.Y., Liu C.L., Lo C.M., Fan S.T. and Lam C.C.K., Living donor liver transplantation for hepatitis C related hepatocellular carcinoma in a haemophilia A patient (Case Report), Haemophilia. 2005, 11(4): 405-407.

Chan S.C., Liu C.L., Lo C.M., Lam B.K.Y., Lee E.W.M., Wong Y. and Fan S.T., Estimating liver weight of adults by body weight and gender, World Journal of Gastroenterology. 2006, 12(14): 2217-2222.

Chan S.C., Fan S.T., Lo C.M. and Liu C.L., Head-to-head comparison of the right and left liver graft in adult-to-adult live donor liver transplantation (Abstract), The 2006 Joint International Congress of the International Liver Transplantation Society (ILTS), the European Liver and Intestinal Transplant Association (ELITA), and the Liver Intensive Care Group of Europe (LICAGE), Milan, Italy, 3 - 6 May 2006. Liver Transplantation. 2006, 12: C34.

Chan S.C., Lo C.M., Wong Y., Liu C.L. and Fan S.T., Long-term biological consequences of donor right hepatectomy including the middle hepatic vein in adult-to-adult live donor liver transplantation, Liver Transplantation. 2006, 12(2): 259-263.

Chan S.C., Fan S.T., Lo C.M. and Liu C.L., Side and size of grafts on surgical outcomes of adult-to-adult live donor liver transplantation (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Chan S.C., Lo C.M., Liu C.L., Wong Y. and Fan S.T., Versatility and viability of hepatic venoplasty in live donor liver transplantation using the right lobe with the middle hepatic vein, Hepatobiliary and Pancreatic Diseases International. 2005, 4(4): 618-621.

Cheung S.T., Liu C.L., Chow J.P.H., Ng I.O.L. and Fan S.T., Preoperative blood test for prognosis of hepatocellular carcinoma (Abstract), The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2-3 December 2005.

Cheung S.T., Liu C.L., Chow J.P.H., Lee Y.T., Ip Y.C., Ho J.C.Y. and Fan S.T., Preoperative plasma transcript AA454543 level is an independent prognostic factor for hepatocellular carcinoma after partial hepatectomy, The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Fan S.T. and Liu C.L., Anterior approach for major right hepatic resection (Review Article), Journal of Hepato-Biliary Pancreatic Surgery. 2005, 12(5): 356-361.

Fan S.T., Lo C.M., Liu C.L. and Chan S.C., First-class Award of the Chinese State Scientific and Technological Progress Award, 2005.

Fan S.T., Lo C.M., Liu C.L. and Chan S.C., Pre-transplant live liver donor evaluation and perioperative care. Protocol of Queen Mary Hospital, University of Hong Kong (Abstract), Vancouver Forum on the Medical Care of the Live Lung, Liver, Intestinal and Pancreas Donor, Vancouver, Canada, 14-16 September 2005.

Lam C.M., Yong J.L., Chan O.O., Ng K.K.C., Poon R.T.P., Liu C.L., Lo C.M. and Fan S.T., Better survival in female patients with hepatocellular carcinoma: oral contraceptive pills related?, Journal of Clinical Gastroenterology. 2005, 39(6): 533-539.

Liem M.S.L., Liu C.L., Tso W.K., Lo C.M., Fan S.T. and Wong J., Portal vein embolisation prior to extended right-sided hepatic resection, Hong Kong Medical Journal. 2005, 11(5): 366-372.

Liu C.L., Acute cholangitis - a review of treatment options (Invited Lecture), Annual Scientific Meeting, St Paul's Doctors' Association, Hong Kong, 17 November 2005. 2005.

Liu C.L. and Fan S.T., Adult-to-adult live-donor liver transplantation: the current status (Invited Paper), Journal of Hepato-Biliary-Pancreatic Surgery. 2006, 13(2): 110-116.

Liu C.L., Anterior approach for right hepatectomy for large Hepatocellular carcinoma (State-of-the-Art Lecture), The 16th World Congress of the International Association of Surgeons of Gastroenterologists, Madrid, Spain, 24 - 27 May 2006. 2006.

Liu C.L., Anterior approach right hepatectomy (Video Presentation), The 16th World Congress of the International Association of Surgeons of Gastroenterologists, Madrid, Spain, 24 - 27 May 2006. 2006.

Liu C.L., Fan S.T., Cheung S.T., Lo C.M., Ng I.O.L. and Wong J., Anterior approach versus conventional approach right hepatic resection for large hepatocellular carcinoma: a prospective randomised controlled study (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Liu C.L., Anterior approach versus conventional approach right hepatic resection for larger hepatocellular carcinoma: a prospective randomized controlled study (Invited Lecture), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006. 2006.

Liu C.L., Associate Editor, Asian Journal of Surgery. 2006.

Liu C.L., Fan S.T., Lo C.M., Tso W.K., Wong Y., Poon R.T.P., Lam C.M., Wong B.C.Y. and Wong J., Clinicobiochemical prediction of biliary cause of acute pancreatitis in the era of endoscopic ultrasonography, Alimentary Pharmacology and Therapeutics. 2005, 22(5): 423-431.

Liu C.L., Fan S.T., Lo C.M., Tso W.K., Wong Y., Poon R.T.P., Lam C.M., Wong B.C.Y. and Wong J., Comparison of early endoscopic ultrasonography and endoscopic retrograde cholangiopancreatography in the management of acute biliary pancreatitis: a prospective randomized study, Clinical Gastroenterology and Hepatology. 2005, 3(12): 1238-1244.

Liu C.L., Consultant (Part-time), Department of Surgery, Queen Mary Hospital, Hong Kong. 2006.

Liu C.L., Donor right hepatectomy including the middle hepatic vein (Invited Lecture), Living Donor Liver Transplantation Symposium 2006, Tokyo, Japan, 30 March 2006. 2006.

Liu C.L., Early detection of common hepatobiliary and pancreatic cancer (Invited Lecture), Scientific Meeting, The Society of Physicians of Hong Kong, Hong Kong, 11 December 2005. 2005.

Liu C.L., Epidemiology and natural history of liver cancer (Invited Lecture), The 6th Liver Update, Selangor, Malaysia, 21 - 24 July 2005. 2005.

Liu C.L., Honorary Consultant, Hong Kong Sanatorium and Hospital. 2006.

Liu C.L., Live donor liver transplantation - Donor morbidity (Invited Lecture), The 6th Liver Update, Selangor, Malaysia, 21 - 24 July 2005. 2005.

Liu C.L., Liver cancer in Hong Kong, Public Talk on Liver Cancer, The Hong Kong Anti-Cancer Society, 27 August 2005. 2005.

Liu C.L., Liver transplantation in Hong Kong, Transplant Course for Nurses, The Association of Hong Kong Nursing Staff, 16 July 2005. 2005.

Liu C.L., Liver transplantation in Hong Kong, Transplant Course for Nurses, The Hong Kong Chinese Civil Servants' Association, 15 November 2005. 2005.

Liu C.L., Member of the Liver Donation Committee, Liver Foundation. 2006.

Liu C.L., Fan S.T., Lo C.M., Wei W.I., Chan S.C., Yong B.H. and Wong J., Operative outcomes of adult-to-adult right lobe live donor liver transplantation: a comparative study with cadaveric whole-graft liver transplantation in a single center, Annals of Surgery. 2006, 243(3): 404-410.

Liu C.L., Protection of the liver during partial hepatectomy (Invited Lecture), The 16th World Congress of the International Association of Surgeons of Gastroenterologists, Madrid, Spain, 24 - 27 May 2006 . 2006.

Liu C.L., Reviewer, European Journal of Gastroenterology and Hepatology. 2006.

Liu C.L., Reviewer, European Journal of Surgical Oncology. 2006.

Liu C.L., Reviewer, Hong Kong Medical Journal. 2006.

Liu C.L., Reviewer, Journal of Gastroenterology and Hepatology. 2006.

Liu C.L., Reviewer, Journal of the Pancreas. 2006.

Liu C.L., Reviewer, Liver International. 2006.

Liu C.L., Reviewer, Liver Transplantation. 2006.

Liu C.L., Reviewer, Surgical Practice. 2006.

Liu C.L., Reviewer, World Journal of Surgical Oncology. 2006.

Liu C.L., Right lobe live donor liver transplantation - the Hong Kong experience (Invited Lecture), The 10th Shanghai - Hong Kong Surgical Forum, Shanghai, China, 11 July 2005. 2005.

Liu C.L., Right-lobe live donor liver transplantation (Invited Lecture), Shanghai - Hong Kong International Liver Congress 2006, Shanghai, China, 25 - 28 March 2006. 2006.

Liu C.L., Right-lobe liver donor liver transplantation with the middle hepatic vein (Invited Lecture), The 15th Conference of Asia Pacific Association of the Study of the Liver, Bali, Indonesia, 18 - 21 August 2005. 2005.

Liu C.L., Should we use left or right liver (Invited Lecture), The 16th World Congress of the International Association of Surgeons of Gastroenterologists, Madrid, Spain, 24 - 27 May 2006. 2006.

Liu C.L., Staging systems of hepatocellular carcinoma with and without liver function (Invited Lecture), The 15th Conference of Asia Pacific Association of the Study of the Liver, Bali, Indonesia, 18 - 21 August 2005. 2005.

Liu C.L., Surgical management of Ca pancreas, CME Meeting for Surgeons, St. Teresa's Hospital, 7 May 2006. 2006.

Liu C.L., Surgical management of difficult biliary strictures (Invited Lecture), The 15th Conference of Asia Pacific Association of the Study of the Liver, Bali, Indonesia, 18 - 21 August 2005. 2005.

Liu C.L., Surgical management of hilar cholangiocarcinoma (Abstract), The 7th Joint Annual Scientific Meeting of the Hong Kong Society of Gastroenterology, Hong Kong Society of Digestive Endoscopy, Hong Kong Society for Coloproctology, Hong Kong Association for the Study of Liver Diseases, and Hong Kong Society of Gastrointestinal Motility, Hong Kong, 27 August 2005.

Liu C.L., Surgical management of hilar cholangiocarcinoma (Invited Lecture), The 7th Joint Annual Scientific Meeting of The Hong Kong Society of Gastroenterology, Hong Kong Society of Digestive Endoscopy, Hong Kong Society for Coloproctology, Hong Kong Association for the Study of Liver Diseases, and Hong Kong Society of Gastrointestinal Motility, 27 August 2005. 2005.

Liu C.L., Surgical treatment for liver cancer, Professional Symposium on Liver Cancer, The Hong Kong Anti-Cancer Society, 27 August 2005. 2005.

Liu C.L., 肝癌治療新發展, The New Horizon Club of Hong Kong, 10 June 2006. 2006.

Liu C.L., The role of preoperative portal vein embolization in hepatectomy for patients with liver cirrhosis (Invited Lecture), Shanghai - Hong Kong International Liver Congress 2006, Shanghai, China, 25 - 28 March 2006. 2006.

Liu C.L., Lo C.M. and Fan S.T., What is the best technique for right hemiliver living donor liver transplantation? With or without the middle hepatic vein? Duct-to-duct biliary anastomosis or Roux-en-Y hepaticojejunostomy? (Invited Article), Journal of Hepatology. 2005, 43(1): 17-22.

Lo C.M., Liu C.L., Lau G., Fan S.T. and Chan S.C., Failure of hepatitis B vaccination in patients receiving lamivudine prophylaxis after liver transplantation for chronic hepatitis B, Journal of Hepatology. 2005, 43(2): 283-287.

Lo C.M., Cheung C.K.Y., Lau G., Yuen R.M.F., Liu C.L., Chan S.H.C., Fan S.T. and Wong J., Significance of hepatitis B virus genotype in liver transplantation for chronic hepatitis B, American Journal of Transplantation. Blackwell, 2005, 5: 1893-900.

Mak C.M., Tam S., Fan S.T., Liu C.L. and Lam C.W., Wilson's disease: a patient undiagnosed for 18 years, Hong Kong Medical Journal. 2006, 12(2): 154-158.

Man K., Sun K.W., Liu C.L., Ng T.P., Ho J.W.Y., Poon R.T.P. and Fan S.T., The significance of cell adhesion kinase in recurrence of hepatocellular carcinoma after curative liver resection (Abstract), The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2-3 December 2005.

Ng K.K.C., Poon R.T.P., Lo C.M., Liu C.L. and Fan S.T., Survival analysis of patients with transplantable hepatocellular carcinoma: an implication for salvage transplantation (Abstract), The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2-3 December 2005.

Ng K.K.C., Poon R.T.P., Lo C.M., Liu C.L., Lam C.M. and Fan S.T., Survival analysis of patients with transplantable recurrent hepatocellular carcinoma: an implication for salvage liver transplantation (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

To Y.F., Sun R.W.Y., Tam P.K.H., Che C.M. and Liu C.L., Anticancer effect of gold (III) porphyrin in nasopharyngeal carcinoma., 97th Annual Meeting of American Association for Cancer Research, Washington, DC, U.S.A., 1-5 April 2006.

Yeung Y.P., Lo C.M., Liu C.L., Wong B.C.Y., Fan S.T. and Wong J., Natural history of untreated nonsurgical hepatocellular carcinoma, American Journal of Gastroenterology. 2005, 100(9): 1995-2004.

Researcher : Liu Y

Project Title:	A study of the effect of vascular endothelial growth factor tyrosine kinase inhibitor PTK 787/ZK222584 on liver fibrosis
Investigator(s):	Liu Y, Poon RTP
Department:	Centre for the Study of Liver Disease
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Abstract:

To investigate the effect of this drug on the development of liver fibrosis, which could potentially make a great contribution to the treatment of human liver fibrosis.

List of Research Outputs

Liu Y., Poon R.T.P., Qian X.M., Li L., Lau C.P.Y., Chen Y.J., Kok T.W. and Fan S.T., A study of the effect of vascular endothelial growth factor tyrosine kinase inhibitor PTK 787/ZK222584 on liver fibrosis (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Liu Y., Poon R.T.P., Li L., Qian X., Chen Y.J., Yang X., Sun H.C., Tang Z.Y. and Fan S.T., Synergistic inhibitory effects of PTK787/ZK222584 and interferon-alfa on hepatocellular carcinoma with metastatic potential (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25 - 28 March 2006.

Liu Y., Poon R.T.P., Li L., Qian X., Chen Y., Xu Y., Sun H.C., Tang Z.Y. and Fan S.T., Synergistic inhibitory effects of PTK787/ZK222584 and interferon-alfa on hepatocellular carcinoma with metastatic potential (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A94.

Yang Z., Liu Y., Ho D.W.Y., Lau C.K., Poon R.T.P. and Fan S.T., Blockade of vascular endothelial growth factor (VEGF) receptor enhances the therapeutic efficacy of hypoxia and chemotherapy in hepatocellular carcinoma (Poster Presentation), The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2 - 3 December 2005.

Researcher : Lo CM

Project Title:	Post-operative adjuvant therapy with recombinant interferon-[alpha] following curative resection of hepatocellular carcinoma: a randomised dose-response controlled trial
Investigator(s):	Lo CM, Fan ST
Department:	Surgery
Source(s) of Funding:	Other Funding Scheme
Start Date:	02/1999

Abstract:

To assess the efficacy and safety of interferon [alpha]-2b in reducing the incidence of recurrence after resection of hepatocellular carcinoma.

Project Title:	Development of anti-HBsAb in patients with chronic hepatitis B after liver transplantation using lamivudine prophylaxis: the possible role of adoptive immunity
Investigator(s):	Lo CM
Department:	Surgery
Source(s) of Funding:	Other Funding Scheme
Start Date:	01/2000

Abstract:

To investigate effects of donor immune status on the development of anti-HBsAb in patients with chronic hepatitis B after liver transplantation.

Project Title:	Hepatitis B virus-specific immune response after liver transplantation for chronic hepatitis B using lamivudine prophylaxis
Investigator(s):	Lo CM, Fan ST, Lau G
Department:	Surgery
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	10/2002

Abstract:

The project attempts to prospectively study the serial changes in HBV-specific immune response after liver transplantation for chronic hepatitis B. This HBV-specific immune response will be correlated with the donor's HBV immune status to clarify the possibility of adoptive immunity transfer through the liver graft.

Project Title:	The effect of FTY720 on hepatic ischemia-reperfusion injury in normal and cirrhotic liver
Investigator(s):	Lo CM, Man K
Department:	Surgery
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003
Completion Date:	10/2005

Abstract:

To study the effect of a novel immunosuppressive drug FTY720 on hepatic ischemia-reperfusion injury in normal and cirrhotic livers by investigation of (1) cell signalling pathways related to acute phase inflammatory responses, cell survival and apoptosis; (2) hepatic ultrastructural features; and (3) liver function.

Project Title:	The significance of hepatic stellate cell activation in marginal liver graft injury
Investigator(s):	Lo CM, Man K
Department:	Surgery
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004
Completion Date:	04/2006

Abstract:

To investigate the significance of activation of hepatic stellate cell at the early phase after liver transplantation in marginal graft injury.

Project Title:	Adoptive transfer of immunity to hepatitis B by using a pre-S containing recombinant vaccine before living donor liver transplantation
Investigator(s):	Lo CM
Department:	Surgery
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2005
Completion Date:	06/2006

Abstract:

N/A

List of Research Outputs

Au W.Y., Liu C.L., Lo C.M., Fan S.T. and Lam C.C.K., Living donor liver transplantation for hepatitis C related hepatocellular carcinoma in a haemophilia A patient (Case Report), Haemophilia. 2005, 11(4): 405-407.

Chan S.C., Liu C.L., Lo C.M., Lam B.K.Y., Lee E.W.M., Wong Y. and Fan S.T., Estimating liver weight of adults by body weight and gender, World Journal of Gastroenterology. 2006, 12(14): 2217-2222.

Chan S.C., Lo C.M. and Fan S.T., Head-to-head comparison of the right and left liver graft in adult-to-adult live donor liver transplantation (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A199.

Chan S.C., Fan S.T., Lo C.M. and Liu C.L., Head-to-head comparison of the right and left liver graft in adult-to-adult live donor liver transplantation (Abstract), The 2006 Joint International Congress of the International Liver Transplantation Society (ILTS), the European Liver and Intestinal Transplant Association (ELITA), and the Liver Intensive Care Group of Europe (LICAGE), Milan, Italy, 3 - 6 May 2006. Liver Transplantation. 2006, 12: C34.

Chan S.C., Lo C.M., Wong Y., Liu C.L. and Fan S.T., Long-term biological consequences of donor right hepatectomy including the middle hepatic vein in adult-to-adult live donor liver transplantation, Liver Transplantation. 2006, 12(2): 259-263.

Chan S.C., Fan S.T., Lo C.M. and Liu C.L., Side and size of grafts on surgical outcomes of adult-to-adult live donor liver transplantation (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Chan S.C., Lo C.M., Liu C.L., Wong Y. and Fan S.T., Versatility and viability of hepatic venoplasty in live donor liver transplantation using the right lobe with the middle hepatic vein, Hepatobiliary and Pancreatic Diseases International. 2005, 4(4): 618-621.

Fan S.T., Lo C.M., Liu C.L. and Chan S.C., First-class Award of the Chinese State Scientific and Technological Progress Award, 2005.

Fan S.T., Lo C.M., Liu C.L. and Chan S.C., Pre-transplant live liver donor evaluation and perioperative care. Protocol of Queen Mary Hospital, University of Hong Kong (Abstract), Vancouver Forum on the Medical Care of the Live Lung, Liver, Intestinal and Pancreas Donor, Vancouver, Canada, 14-16 September 2005.

Hui C.K., Lai L.S., Lam P., Zhang H., Fung T.T., Lai S.T., Wong W.M., Lo C.M., Fan S.T., Leung N. and Lau G., 48 weeks pegylated interferon alpha-2a is superior to 24 weeks of pegylated interferon alpha-2b in achieving hepatitis B e antigen seroconversion in chronic hepatitis B infection, Alimentary Pharmacology and Therapeutics. 2006, 23(8): 1171-1178.

Hui C.K., Lau E., Kim M., Monto A., Luk J.M., Leung N., Lo C.M., Fan S.T., Wright T.L. and Lau G., Fibrosis Porgression in Patients with Recurrent Chronic Hepatitis C Virus and Occult Hepatitis B Co-Infection After Liver transplantation, J Gastroenterol and Hepatol. 2006, 21(2): A80.

Hui C.K., Lau E., Kim M., Monto A., Luk J.M.C., Leung N., Lo C.M., Fan S.T., Wright T.L. and Lau G., Fibrosis progression in patients with recurrent chronic hepatitis C virus and occult hepatitis B co-infection after liver transplantation (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A80.

Hui C.K., Lau E., Monto A., Kim M., Luk J.M.C., Poon R.T.P., Leung N., Lo C.M., Fan S.T. and Lau G., Natural history of patients with recurrent chronic hepatitis C virus and occult hepatitis B co-infection after liver transplanation, AM J Transplanation. 2006, 6(7): 1600-8.

Hui C.K., Zhan H.Y., Lee N.P., Yueng Y.H., Lu L., Leung N., Wong B.C., Lo C.M., Fan S.T., Luk J.M.C. and Lau G., Upregulation of toll-like receptor 7 is essential for serological clearance of hepatitis B surface antigen in chronic hepatitis B (HBV) infection, Hepatology. 2005, 42(4): 707A-708A, Suppl 1.

Hui C.K., Zhang H., Lee N.W., Lu L., Leung N., Wong B.C.Y., Lo C.M., Fan S.T., Luk J.M.C. and Lau G., Upregulation of toll-like receptor 7 is essential for serological clearance of hepatitis B surface antigen in chronic hepatitis B virus (HBV) infection, Liver International 2005. 2005, Oct: 196.

Lai L.S.W., Fung T.T., Lai S.T., Yiu J., Lam P., Zhang H., Wong W.M., Lo C.M., Fan S.T., Hui C.K., Leung N. and Lau G., 48 weeks pegylated interferon alfa-2a is superior to 24 weeks of pegylated interferon alfa-2b in achieving HBeAg seroconversion in chronic hepatitis B infection (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A90.

Lai S.W., Fung S.T., Lai S.T., Yiu J., Lam P., Zhang H.Y., Wong W.M., Lo C.M., Fan S.T., Leung N. and Lau G., 48 Weeks Pegylated Interferon Alfa-2a is superior to 24 Weeks of Pegylated interferon Alfa-2b in Achieving HBeAg seroconversion in Chronic Hepatitis Infection, J Gastronenterol and Hepatol. 2006, 21(2): A90.

Lam C.M., Yong J.L., Chan O.O., Ng K.K.C., Poon R.T.P., Liu C.L., Lo C.M. and Fan S.T., Better survival in female patients with hepatocellular carcinoma: oral contraceptive pills related?, Journal of Clinical Gastroenterology. 2005, 39(6): 533-539.

Lam S., Man K., Ng T.P., Fan S.T. and Lo C.M., The significance of hepatic stellate cell activation in small-for-size fatty liver graft injury (Abstract), The 11th Congress of the International Liver Transplantation Society, Los Angeles, U.S.A., 20 - 23 July 2005.

Liem M.S.L., Poon R.T.P., Lo C.M., Tso W.K. and Fan S.T., Outcome of transarterial chemoembolization in patients with inoperable hepatocellular carcinoma eligible for radiofrequency ablation, World Journal of Gastroenterology. 2005, 11(29): 4465-4471.

Liem M.S.L., Liu C.L., Tso W.K., Lo C.M., Fan S.T. and Wong J., Portal vein embolisation prior to extended right-sided hepatic resection, Hong Kong Medical Journal. 2005, 11(5): 366-372.

Liu C.L., Fan S.T., Cheung S.T., Lo C.M., Ng I.O.L. and Wong J., Anterior approach versus conventional approach right hepatic resection for large hepatocellular carcinoma: a prospective randomised controlled study (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Liu C.L., Fan S.T., Lo C.M., Tso W.K., Wong Y., Poon R.T.P., Lam C.M., Wong B.C.Y. and Wong J., Clinicobiochemical prediction of biliary cause of acute pancreatitis in the era of endoscopic ultrasonography, Alimentary Pharmacology and Therapeutics. 2005, 22(5): 423-431.

Liu C.L., Fan S.T., Lo C.M., Tso W.K., Wong Y., Poon R.T.P., Lam C.M., Wong B.C.Y. and Wong J., Comparison of early endoscopic ultrasonography and endoscopic retrograde cholangiopancreatography in the management of acute biliary pancreatitis: a prospective randomized study, Clinical Gastroenterology and Hepatology. 2005, 3(12): 1238-1244.

Liu C.L., Fan S.T., Lo C.M., Wei W.I., Chan S.C., Yong B.H. and Wong J., Operative outcomes of adult-to-adult right lobe live donor liver transplantation: a comparative study with cadaveric whole-graft liver transplantation in a single center, Annals of Surgery. 2006, 243(3): 404-410.

Liu C.L., Lo C.M. and Fan S.T., What is the best technique for right hemiliver living donor liver transplantation? With or without the middle hepatic vein? Duct-to-duct biliary anastomosis or Roux-en-Y hepaticojejunostomy? (Invited Article), Journal of Hepatology. 2005, 43(1): 17-22.

Lo C.M., Advances in living donor liver transplantation (Invited Lecture), International Symposium on Recent Advances in Molecular Clinical and Social Medicine, Shantou, China, 3 - 5 December 2005. 2005.

Lo C.M., Advances in living donor liver transplantation (Plenary Presentation), The 24th Annual Meeting of the Egyptian Society of Surgeons, Cario, Egypt, 22-24 February 2006. 2006.

Lo C.M., American Journal of Transplantation, Associate Editor (2006 - present). 2006.

Lo C.M., Anti-viral therapy and active immunization for prevention of recurrent hepatitis B after liver transplantation, Asian Pacific Digestive Week 2005, Seoul, Korea, 25-28 September 2005. 2005.

Lo C.M., Approaching zero transfusion in liver transplantation (Invited Lecture), The 2nd Asian NATA Symposium on Transfusion Medicine and Alternatives, Hong Kong, 14-15 January 2006. 2006.

Lo C.M., Approaching zero transfusion in liver transplantation, 2nd Asian NATA Symposium on Transfusion Medicine and Alternatives, Hong Kong, 14-15 January 2006.

Lo C.M., Associate Director (1994 - present), Liver Transplant Centre, Queen Mary Hospital, Hospital Authority, Hong Kong. 2006.

Lo C.M., Associate Editor (2001 - present), Digestive Surgery. 2006.

Lo C.M., Associate Editor (2005 - present), World Journal of Surgery. 2006.

Lo C.M., Council Member (1997 - present), Hong Kong Society of Transplantation. 2006.

Lo C.M., Council Member (2005 - present), The College of Surgeons of Hong Kong. 2006.

Lo C.M., Evidence-based management of hepatocellular carcinoma, 24th Annual Meeting of the Egyptian Society of Surgeons, Cario, Egypt, 22-24 February 2006. 2006.

Lo C.M., Examiner in Licentiate Examination, the Licentiate Committee (1995 - present), Medical Council of Hong Kong. 2006.

Lo C.M., Executive Committee Member (1998 - present), International Society for Digestive Surgery. 2006.

Lo C.M., Liu C.L., Lau G., Fan S.T. and Chan S.C., Failure of hepatitis B vaccination in patients receiving lamivudine prophylaxis after liver transplantation for chronic hepatitis B, Journal of Hepatology. 2005, 43(2): 283-287.

Lo C.M., Guest Professor (2002 - present), The Peking University Health Science Centre, Peking University First Hospital, China. 2006.

Lo C.M., Guest Professor (2004 - present), Army Institute of Hepatobiliary Surgery, Southwest Hospital, Third Military Medical University, China . 2006.

Lo C.M., HBV, The 2006 Joint International Congress of International Liver Transplantation Society (ILTS), the European Liver and Intestinal Transplant Association (ELITA) and the Liver Intensive Care Group of Europe (LICAGE), Milan, Italy, 3-6 May 2006. 2006.

Lo C.M., Honorary Consultant (1998 - present), Queen Mary Hospital, Hospital Authority, Hong Kong. 2006.

Lo C.M., Honorary Consultant (2002 - present), King Faisal Hospital & Research Centre, Kingdom of Saudi Arabia. 2006.

Lo C.M., Honorary Consultant (2005 - present), Hong Kong Sanatorium and Hospital, Hong Kong. 2006.

Lo C.M., Honorary Senior Consultant (2002 - present), Tung Wah Hospital, Hospital Authority, Hong Kong. 2006.

Lo C.M., Living donor ECD, ILTS Consensus Development Symposium on Extended Criteria Liver Donors, Philadelphia, PA, USA, 1-2 December 2005. 2005.

Lo C.M., Living related liver transplantation in Asia (State-of-the-Art Lecture), The 2006 Joint International Congress of the International Liver Transplantation Society (ILTS), the European Liver and Intestinal Transplant Association (ELITA) and the Liver Intensive Care Group of Europe (LICAGE), Milan, Italy, 3-6 May 2006. 2006.

Lo C.M., Member of Editorial Board (2002 - present), Hepatobiliary and Pancreatic Diseases International. 2006.

Lo C.M., Member of Editorial Board (2002 - present), Surgery. 2006.

Lo C.M., Member of Editorial Board (2004 - 2005), World Journal of Surgery. 2006.

Lo C.M., Member of Editorial Board (2006 - present), Annals of Surgery. 2006.

Lo C.M., Member of Scientific Committee (1998 - present), Cheng Si Yuan China-International Hepatitis Research Foundation . 2006.

Lo C.M., Member, Board of Examiners (2002 - present), The College of Surgeons of Hong Kong. 2006.

Lo C.M., Member, Exemptions Sub-Committee, the Licentiate Committee (2003 - present), Medical Council of Hong Kong. 2006.

Lo C.M., Member, Panel of Assessors (2004 - present), Medical Council of Hong Kong. 2006.

Lo C.M., National Delegate (1998 - present), International Society for Digestive Surgery. 2006.

Lo C.M., National Editor (2005 - present), Hepato-Gastroenterology. 2006.

Lo C.M., Outstanding Researcher Award, The Universtiy of Hong Kong . 2005.

Lo C.M., Overview of experience: The University of Hong Kong, 2006 Living Donor Liver Transplantation Symposium, Tokyo, Japan, 30 March 2006. 2006.

Lo C.M., President (2003 - present), Hong Kong Society of Transplantation. 2006.

Lo C.M., President (2004 - present), International Society for Digestive Surgery. 2006.

Lo C.M., Prevention of HBV recurrence after liver transplantation, Shanghai – Hong Kong International Liver Congress, Shangha, China, 25-28 March 2006. 2006.

Lo C.M., Program Committee Member (1997 - present), International Society for Digestive Surgery. 2006.

Lo C.M., Reviewer, UICC Fellowship Selection Committee (1997 - present), Internaional Union Against Cancer. 2006.

Lo C.M., Reviewer, American Journal of Transplantation. 2006.

Lo C.M., Reviewer, Annals of Surgery. 2006.

Lo C.M., Reviewer, Annals of the College of Surgeons of Hong Kong. 2006.

Lo C.M., Reviewer, Asian Journal of Surgery. 2006.

Lo C.M., Reviewer, British Journal of Surgery. 2006.

Lo C.M., Reviewer, Endoscopy. 2006.

Lo C.M., Reviewer, Hepatology. 2006.

Lo C.M., Reviewer, Hong Kong Medical Journal. 2006.

Lo C.M., Reviewer, Liver Transplantation. 2006.

Lo C.M., Reviewer, Surgery. 2006.

Lo C.M., Cheung C.K.Y., Lau G., Yuen R.M.F., Liu C.L., Chan S.H.C., Fan S.T. and Wong J., Significance of hepatitis B virus genotype in liver transplantation for chronic hepatitis B, American Journal of Transplantation. Blackwell, 2005, 5: 1893-900.

Lo C.M., Steering Committee Member (2002 - present), Asian Pacific Digestive Week. 2006.

Lo C.M., Surgical therapies for hepatocellular carcinoma, Asian Pacific Digestive Week 2005, Seoul, Korea, 25-28 September 2005. 2005.

Lo C.M., Treatment of hepatocellular carcinoma: Surgeon’s role, The Autumn Meeting of Taiwan Surgical Society of Gastroenterology, Taiwan, 5 November 2005. 2005.

Luo Y., Lo C.M. and Cheung C.K.Y., Cross-sectional study on hepatitis B virus-specific CD4+ T cell immune response after liver transplantation (Abstract), The 2006 Joint International Congress of the International Liver Transplantation Society (ILTS), the European Liver and Intestinal Transplant Association (ELITA), and the Liver Intensive Care Group of Europe (LICAGE), Milan, Italy, 3 - 6 May 2006. Liver Transplantation. 2006, 12: C101.

Man K., Zhao Y., Xu A., Lo C.M., Lam K.S., Ng K.T., Ho J.W.Y., Sun C.K. and Lee K.W., FTY720 significantly improves small-for-size fatty liver graft survival, American Journal of Transplantation. 2006, 6(3): 467-476.

Man K., Zhao Y., Xu A., Lo C.M., Lam K.S.L., Ng T.P., Ho J.W.Y., Sun K.W., Lee K.W., Li X. and Fan S.T., Fat-derived hormone adiponectin combined with FTY720 significantly improves small-for-size fatty liver graft survival, American Journal of Transplantation. 2006, 6(3): 467-476.

Man K., Su M., Ng T.P., Lo C.M. and Fan S.T., Rapamycin attenuates liver graft injury in a cirrhotic rat liver transplantation model - the significance of down-regulation of Rho-ROCK pathway (Abstract), The 11th Congress of the International Liver Transplantation Society, Los Angeles, U.S.A., 20 - 23 July 2005.

Man K., Su M., Ng T.P., Lo C.M., Zhao Y., Ho J.W.Y., Sun K.W., Lee K.W. and Fan S.T., Rapamycin attenuates liver graft injury in cirrhotic recipient - the significance of down-regulation of Rho-ROCK-VEGF pathway, American Journal of Transplantation. 2006, 6(4): 697-704.

Man K., Lo C.M., Ng T.P., Sun K.W. and Fan S.T., Significant activation of cell invasion, migration and angiogenesis pathways in small-for-size grafts may potentially increase tumor recurrence after living donor liver transplantation (Abstract), The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2-3 December 2005.

Man K., Lo C.M., Ng T.P., Xiao J., Sun K.W., Su M. and Fan S.T., Significant activation of cell invasion, migration and angiogenesis pathways in small-for-size grafts may potentially increase tumour recurrence after living donor liver transplantation (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Man K., Lo C.M., Ng T.P., Ng T.P., Sun K.W. and Fan S.T., Significant activation of cell invasion, migration and angiogensis pathways in small-for-size grafts may potential increase tumor recurrence after living donor liver transplantation (Abstract), The 11th Congress of the International Liver Transplantation Society, Los Angeles, U.S.A., 20 - 23 July 2005.

Man K., Lo C.M., Ng T.P., Sun K.W. and Fan S.T., The significance of acute phase graft injury on tumor recurrence and metastases in living donor liver transplantation (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A204.

Man K., Lo C.M., Xiao J.W., Ng T.P., Ng I.O.L., Sun K.W., Cheng Q. and Fan S.T., The significance of graft size on tumor recurrence/metastases after liver transplantation – Activation of cell invasion and migration pathways (Abstract), The 2006 Joint International Congress of the International Liver Transplantation Society (ILTS), the European Liver and Intestinal Transplant Association (ELITA), and the Liver Intensive Care Group of Europe (LICAGE), Milan, Italy, 3 - 6 May 2006. Liver Transplantation. 2006, 12: C30.

Ng K.K.C., Lo C.M., Chan S.C. and Fan S.T., Increasing applicability of liver transplantation over 13 years - a single institution experience (Oral Presentation), The Annual Scientific Meeting of the Hong Kong Society of Transplantation, Hong Kong, 2 April 2006.

Ng K.K.C., Poon R.T.P., Lo C.M., Yuen J.H.F., Tso W.K. and Fan S.T., Recurrence pattern and survival outcome after radiofrequency ablation of hepatocellular carcinoma (Abstract), The 16th World Congress of the International Association of Surgeons and Gastroenterologists, Madrid, Spain, 25 - 27 May 2006.

Ng K.K.C., Poon R.T.P., Lo C.M., Liu C.L. and Fan S.T., Survival analysis of patients with transplantable hepatocellular carcinoma: an implication for salvage transplantation (Abstract), The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2-3 December 2005.

Ng K.K.C., Poon R.T.P., Lo C.M., Liu C.L., Lam C.M. and Fan S.T., Survival analysis of patients with transplantable recurrent hepatocellular carcinoma: an implication for salvage liver transplantation (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Xu X., Man K., Zheng S.S., Liang T.B., Lee K.W., Ng T.P., Fan S.T. and Lo C.M., Attenuation of acute phase shear stress by somatostatin improves small-for-size liver graft survival, Liver Transplantation. 2006, 12(4): 621-627.

Yeung Y.P., Lo C.M., Liu C.L., Wong B.C.Y., Fan S.T. and Wong J., Natural history of untreated nonsurgical hepatocellular carcinoma, American Journal of Gastroenterology. 2005, 100(9): 1995-2004.

Researcher : Lo CY

Project Title:	Establishment of a comprehensive service and registry for hereditary familial endocrinopathy syndromes in Hong Kong
Investigator(s):	Lo CY, Lam KSL, Tam S.C.F.
Department:	Surgery
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	01/2005

Abstract:

To provide a comprehensive clinical, genetic and counseling services for the diagnosis, management, screening and education of familial endocrinopathy syndromes; to establish a registry on all index patients as well as their family members with familial endocrinopathy syndromes in Hong Kong with respect to detailed information including the type of endocrinopathy sydromes, familial pedigrees, patients' demographics, presentation, surgical treatment, pathology of tumours, genetic changes, outcome and follow-up; to improve the standard of care for patients with familial endocrinopathy syndromes through this program; to educate the public and the medical professions advance and the role of genetics in management of these hereditary conditions; to conduct on-going research on familial endocrine diseases by establishing a tissue and serum bank from patients and relatives with familial endocrinopathy sydromes.

List of Research Outputs

Chan W.F. and Lo C.Y., Pitfalls of intraoperative neuromonitoring for predicting postoperative recurrent laryngeal nerve function during thyroidectomy, World Journal of Surgery. 2006, 30: 806-812.

Chan W.F. and Lo C.Y., Pitfalls of intraoperative neuromonitoring in predicting postoperative recurrent laryngeal nerve dysfunction during thyroidectomy (Abstract), International Associatio of Endocrine Surgeons, International Surgical Week 2005, Durban, South Africa, 21-25 August 2005.

Ku C.F., Lo C.Y., Chan W.F., Kung A.W.C. and Lam K.S.L., Total thyroidectomy replaces subtotal thyroidectomy as the preferred surgical treatment for Graves' disease, ANZ J Surg. 2005, 75(7):: 528-31.

Lam A.K.Y., Lo C.Y. and Lam K.S.L., Papillary carcinoma of thyroid: A 30-yr clinicopathological review of the histological variants, In: Tischeler Arthur S, Endocrine Pathology. 2005, 16(4): 323-330.

Lam P.K.Y. and Lo C.Y., Diffuse sclerosing variant of papillary carcinoma of the thyroid: a 35 year comparative study at a single institution, Annals of Surgical Oncology. 2006, 13: 1-6.

Lang B.H., Lo C.Y., Chan W.F., Lam K.Y. and Wan K.Y., Classical and follicular variant of papillary thryoid carcinoma: A comparative study on clinicopathologic features and long-term outcome (Abstract), International Association of Endocrine Surgeons, International Surgical Week 2005, Durban, South Africa, 21-25 August 2005.

Lang B.H. and Lo C.Y., Total thyroidectomy for multinodular goiter in the elderly, American Journal of Surgery. 2005, 190: 418-423.

Lang B.H.H., Lo C.Y., Chan W.F., Chan A.K.Y. and Wan K.Y., Classical and follicular variant of papillary thyroid carcinoma: A comparative study on clinicopathologic features and long-term outcome, World Journal of Surgery. 2006, 30: 752-758.

Lau H., Lo C.Y., Patil N.G. and Yuen W.K., Early versus delayed-interval laparoscopic cholecystectomy for acute cholecystitis: a metaanalysis, Surgical Endoscopy. 2006, 20(1): 82-87.

Lo C.Y., Ad-hoc Reviewer, Expert Review of Anticancer Therapy. 2006.

Lo C.Y., Ad-hoc reviewer, Annals of College of Surgeons of Hong Kong/Surgical Practice. 2006.

Lo C.Y., Ad-hoc reviewer, Asian Journal of Surgery. 2006.

Lo C.Y., Ad-hoc reviewer, Australasian & New Zealand Journal of Surgery. 2006.

Lo C.Y., Ad-hoc reviewer, British Journal of Surgery. 2006.

Lo C.Y., Ad-hoc reviewer, Clinical Endocrinology. 2006.

Lo C.Y., Ad-hoc reviewer, Endoscopy. 2006.

Lo C.Y., Ad-hoc reviewer, Expert Reviews of Molecular Diagnostics. 2006.

Lo C.Y., Ad-hoc reviewer, Journal of American College of Surgeons. 2006.

Lo C.Y., Ad-hoc reviewer, Surgery. 2006.

Lo C.Y., Ad-hoc reviewer, The Hong Kong Medical Journal. 2006.

Lo C.Y., Ad-hoc reviewer, The Lancet Oncology. 2006.

Lo C.Y., Ad-hoc reviewer, World Journal of Surgery. 2006.

Lo C.Y., Associate Editor (2005 - present), Asian Journal of Surgery. 2006.

Lo C.Y., Congress President, 10th Congress Asian Association of Endocrine Surgeons. 2006.

Lo C.Y., Corresponding member (1998 - present), American Association of Endocrine Surgeons. 2006.

Lo C.Y., Council Member (1996 - present), Asian Association of Endocrine Surgeons. 2006.

Lo C.Y., Council member (2005 - 2007), International Association of Endocrine Surgeons. 2006.

Lo C.Y., Council member (2005 - 2007), Society of Minimal Access Surgery in Hong Kong. 2006.

Lo C.Y., Council member (2006 - 2008), The College of Surgeons of Hong Kong. 2006.

Lo C.Y., Chan W.F., Lam K.Y. and Wan K.Y., Follicular thyroid carcinoma: The role of histology and staging systems in predicting survival, Annals of Surgery. 2005, 242: 708-715.

Lo C.Y., Honorary Consultant (2000 - present), The Junior Police Arm Force Association. 2005.

Lo C.Y., Honorary Consultant (2005 - present), Department of Surgery, Tung Wah Hospital, Hong Kong West Cluster. 2006.

Lo C.Y., Honorary Consultant (2005 - present), Hong Kong Sanatorium & Hospital. 2006.

Lo C.Y., International expert panel (2004 - present), Minimally Invasive Centre, National University Singapore. 2006.

Lo C.Y., Invited Faculty, Preparatory course for exit examination in General Surgery, The College of Surgeons of Hong Kong, Hong Kong, 29 August - 2 September 2005. 2005.

Lo C.Y., Invited Speaker: Characteristics of Medical Curriculum in Faculty of Medicine in the University of Hong Kong, Symposium in Medical Education, Faculty of Medicine in Zhijiang University, Zhijiang Province, China, 12 November 2005. 2005.

Lo C.Y., Invited keynote speaker: New frontier in endocrine surgery and laparoscopic partial pancreatectomy for islet cell tumors, Annual Scientific Meeting, Macao Surgery Association, Macau, 17-18 June 2006. 2006.

Lo C.Y., Invited speaker: Management of locally advanced thyroid carcinoma , Hong Kong Surgical Forum, 8-9 July 2005, Queen Mary Hospital, Hong Kong. 2005.

Lo C.Y., Invited speaker: Medullary thyroid carcinoma and persistent hypercalcitoninaemia, Tumour Board Meeting in Hong Kong Sanatorium & Hosptial, Hong Kong, 12 April 2006. 2006.

Lo C.Y., Management of locally advanced thyroid cancer (Invited), 57th Annual Meeting of Korean Surgical Society and Korean Association of Endocrine Surgeons, Seoul, Korea, 28 October 2005.

Lo C.Y., Management of locally advanced thyroid cancer (Invited), International Association of Endocrine Surgeons, International Surgical Week 2005, Durban, South Africa, 21-25 August 2005.

Lo C.Y., Management of locally advanced thyroid carcinoma (Invited), 10th Joint Hong Kong-Shanghai Surgical Forum, Rui Jin Hospital, Shanghai, China, 11 July 2005.

Lo C.Y., Management of locally advanced thyroid carcinoma , 10th Joint Hong Kong-Shanghai Surgical Forum, 11th July 2005, Rui Jin Hospital, Shanghai. 2005.

Lo C.Y., Member (1987 - present), Hong Kong Medical Association. 2006.

Lo C.Y., Member (1992 - present), Asian Surgical Association. 2006.

Lo C.Y., Member (1992 - present), Society of Minimal Invasive Surgery. 2006.

Lo C.Y., Member (1995 - present), International Association of Endocrine Surgoens. 2006.

Lo C.Y., Member (1995 - present), International Surgical Society. 2006.

Lo C.Y., Member (1995 - present), Public Doctors' Association. 2006.

Lo C.Y., Member (2002 - present), Continued Medical Education Subcommittee, Hong Kong Medical Association. 2006.

Lo C.Y., Member (2004 - present), Minimal Access Surgery Training Coordination Committee, The College of Surgeons of Hong Kong. 2006.

Lo C.Y., Member (2004 - present), the Task Force of Subspecialty Training in General Surgery, The College of Surgeons of Hong Kong. 2006.

Lo C.Y., Member of Editorial Board (1 February 2002 to present), Asian Journal of Surgery. 2006.

Lo C.Y., Member of Editorial Board (January 2006 - present), Chinese Journal of Medicine. 2006.

Lo C.Y., Member of International Advisory Board (2002 - present), Chinese Journal of Endocrine Surgery. 2006.

Lo C.Y., Member, Scientific Programme Committee, Conjoint Scientific Congress, The Royal College of Surgeons of Edinburgh and the College of Surgeons of Hong Kong. 2006.

Lo C.Y., Minimally Invasive Thyroid and Parathyroid Surgery. Thyroid Surgery, (盧寵猷醫生甲狀腺和甲狀旁腺的微創手術.甲狀腺外科. 人民衛生出版社2005 第二十六章: 386-390), Thyroid Surgery. People's Medical Publishing House 2005, 2005, 26 : 386-390.

Lo C.Y., National Delegate (2006 - 2010), International Surgical Society. 2006.

Lo C.Y., Chan W.F., Lang B.H.H., Chan K.Y. and Wan K.Y., Papillary microcarcinoma: Is there any difference between clinically overt and occult tumors?, World Journal of Surgery. 2006, 30: 759-765.

Lo C.Y., President (2004 - 2006), 10th Congress Asian Association of Endocrine Surgeons. 2006.

Lo C.Y., Special lecture: Management of locally advanced thyroid cancer , 57th Annual Meeting of Korean Surgical Society and Korean Association of Endocrine Surgeons, 28 October, 2005 Intercontintential Hotel, Seoul, Korea. 2005.

Lo C.Y., Transaxillary endoscopic thyroidectomy (Invited video-presentation), Annual Scientific Meeting, Macao Surgery Association, Macau, 17-18 June 2006. 2006.

Lo C.Y., Visiting lecture: Optimizing the outcome of thyroid surgery, Faculty of Medicine, Universiti Kebangsaan Malaysia, Kula Lumpur, Malaysia, 15 May 2006. 2006.

Singh N., Lo C.Y. and Chan W.F., Laparoscopic enucleation of a nonfunctioning neuroendocrine tumor at the head of the pancreas, Journal of the Laparoendoscopic Surgeons. 2006, 10(2): 259-262.

Yong J.L., Law W.L., Lo C.Y. and Lam C.M., A comparative study of routine laparoscopic versus open appendectomy, Journal of the Society of Laparoendoscopic Surgeons. 2006, 10(2): 188-192.

Yu X.M., Lo C.Y., Chan W.F., Lam K.Y., Leung P. and Luk J.M.C., Increased expression of vascular endothelial growth factor c in papillary thyroid carcinoma correlates with cervical lymph node metastases, Clinical Cancer Research. 2005, 11(22): 8063-8069.

Researcher : Loo TY

List of Research Outputs

Chen J., Loo T.Y. and Chow W., The therapeutic effect of Shugansanjie Tang on human breast tumor tissue in vitro, OOTR. 2005.

Cheng C.K., Chow L.W.C., Loo T.Y., Chan T.K. and Chan V.N.Y., The cell cycle checkpoint gene Rad9 is a novel oncogene activated by 11q13 amplification and DNA methylation in breast cancer, Cancer Research. 2005, 65: 8646-8654.

Chow L.W.C., Zhu L., Loo T.Y. and Lui E.L.H., Aberrant methylation of cyclooxygenase-2 in breast cancer patients, Biomedicine & Pharmacotherapy. 2005, 59: S264-S267.

Chow L.W.C., Loo T.Y. and Toi M., Current directions for COX-2 inhibition in breast cancer, Biomedicine & Pharmacoltherapy. 2005, 59: S281-S284.

Chow L.W.C., Loo T.Y., Wai C.C.Y., Lui E.L.H., Zhu L. and Toi M., Study of COX-2, Ki67 and p53 expression to predict effectiveness of 5-flurouracil, epirubicin and cyclophosphamide with celecoxib treatment in breast cancer patients, Biomedicine & Pharmacotherapy. 2005, 59: S298-S301.

Loo T.Y., Fong J.H.M., Cheung M.N.B. and Chow L.W.C., The efficacy of Paclitaxel on solid tumour analysed by ATP bioluminescence assay and VEGF expression: a translational research study, Biomedicine & Pharmacotherapy. 2005, 59: S337-S339.

Loo T.Y., Fong J.H.M., Zhu L., Cheung M.N.B. and Chow L.W.C., The value of bone marrow aspirates culture for the detection of bone marrow micrometastasis in breast cancer, Biomedicine & Pharmacotherapy. 2005, 59: S384-S386.

Lui E.L.H., Loo T.Y., Zhu L., Cheung M.N.B. and Chow L.W.C., DNA hypermethylation of TIMP3 gene in invasive breast ductal carcinoma, Biomedicine & Pharmacotherapy. 2005, 59: S363-S365.

Zhu L., Loo T.Y. and Chow L.W.C., Circulating tumor cells in patients with breast cancer: possible predictor of mciro-metastasis in bone marrow but not in sentinel lymph nodes, Biomedicine & Pharmacotherapy. 2005, 59: S355-S358.

Zhu L., Loo T.Y. and Chow L.W.C., Cyclooxygenase-2: possible predictor related to micrometastasis in breast cancer patients (Abstract), Biomedicine & Pharmacotherapy. 2005, 59: S318.

Researcher : Lu L

List of Research Outputs

Hui C.K., Zhan H.Y., Lee N.P., Yueng Y.H., Lu L., Leung N., Wong B.C., Lo C.M., Fan S.T., Luk J.M.C. and Lau G., Upregulation of toll-like receptor 7 is essential for serological clearance of hepatitis B surface antigen in chronic hepatitis B (HBV) infection, Hepatology. 2005, 42(4): 707A-708A, Suppl 1.

Hui C.K., Zhang H., Lee N.W., Lu L., Leung N., Wong B.C.Y., Lo C.M., Fan S.T., Luk J.M.C. and Lau G., Upregulation of toll-like receptor 7 is essential for serological clearance of hepatitis B surface antigen in chronic hepatitis B virus (HBV) infection, Liver International 2005. 2005, Oct: 196.

Researcher : Lui ELH

List of Research Outputs

Chow L.W.C., Zhu L., Loo T.Y. and Lui E.L.H., Aberrant methylation of cyclooxygenase-2 in breast cancer patients, Biomedicine & Pharmacotherapy. 2005, 59: S264-S267.

Chow L.W.C., Loo T.Y., Wai C.C.Y., Lui E.L.H., Zhu L. and Toi M., Study of COX-2, Ki67 and p53 expression to predict effectiveness of 5-flurouracil, epirubicin and cyclophosphamide with celecoxib treatment in breast cancer patients, Biomedicine & Pharmacotherapy. 2005, 59: S298-S301.

Lui E.L.H., Loo T.Y., Zhu L., Cheung M.N.B. and Chow L.W.C., DNA hypermethylation of TIMP3 gene in invasive breast ductal carcinoma, Biomedicine & Pharmacotherapy. 2005, 59: S363-S365.

Researcher : Lui VCH

Project Title:	Cre-inducible disruption of Hedgehog signaling in neural crest cell: a novel approach to study roles of Hedgehog in enteric nerous system development
Investigator(s):	Lui VCH, Tam PKH, Sham MH
Department:	Surgery
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Abstract:

To generate a DNA construct for Cre-inducible expression of a Ptc1^[Delta]loop2 protein; to generate transgenic mice carrying the Ptc1^[Delta]loop2 DNA construct by microinjection; transgenic mice will be crossed with a vagal NCC specific Cre mouse strain; to analysis of abnormal phenotypes in the devleoping ENS of the transgenic mutant mice.

Project Title:	Conditional knockout of Patched gene in enteric neural crest cells: functional study of the role of Hedgehog signaling in enteric nervous system development
Investigator(s):	Lui VCH, Tam PKH, Sham MH, Hui C.C.
Department:	Surgery
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	10/2004

Abstract:

To cross floxed Ptc1 mice with a vagal NCC specific Cre mouse strain (b3-IIIa-cre); to analyze the abnormal phenotypes in the developing ENS of the transgenic mutant mice; to analyze the effects of mesenchyme-derived factors on NCCs of the transgenic mutant mice.

Project Title:	Investigation of Hoxb5 functions in enteric neurons in late gestation and neonatal period
Investigator(s):	Lui VCH, Sham MH, Tam PKH
Department:	Surgery
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Abstract:

To investigate the functions of Homeobox gene Hoxb5 in enteric neurons.

Project Title:	Conditional knockout of Patched gene in enteric neural crest cells: functional study of the role of Hedgehog signaling in enteric nervous system development
Investigator(s):	Lui VCH
Department:	Surgery
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

N/A

Project Title:	*Functional analysis of Hoxb5* in enteric neurons in mice**
Investigator(s):	Lui VCH
Department:	Surgery
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	11/2005

Abstract:

N/A

Project Title:	*Functional analysis of Hoxb5* in enteric neurons in mice**
Investigator(s):	Lui VCH, Sham MH, Tam PKH
Department:	Surgery
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	11/2005

Abstract:

To analyse the expression pattern of Hoxb5 protein in enteric neurons in postnatal and adult mice; to induce the expression of en-hoxb5 in enteric neurons in late stage of ENS development and shall analyse the phenotypic consequence of the perturbation of hoxb5 function in the ENS of postnatal and adult mice.

List of Research Outputs

Garcia-Barcelo M.M., So M.T., Lau K.C., Leon Y.Y., Yuan Z., Cai W., Lui V.C.H., Fu M., Herbrick J.A., Gutter E., Proud V., Li L., Pierre-Louis J., Aleck K., van Heurn E., Belloni E., Scherer S.W. and Tam P.K.H., Population differences in the polyalanine domain and 6 new mutations in HLXB9 in patients with Currarino syndrome, Clinical Chemistry. 2006, 52(1): 46-52.

Lau K.C., Garcia-Barcelo M.M., Leon Y.Y., So M.T., Miao X., Ngan E.S.W., Lui V.C.H., Cass D.T., Croaker G.D.H. and Tam P.K.H., Evaluation of thyroid transcription factor 1 (TTF-1) as a Hirschsprung's disease (HSCR) locus by mutation analysis, 39th Annual Meeting of the Pacific Association of Pediatric Surgeons, Taipei, Taiwan, 14-18 May 2006.

Law M.L., Tsang W.H., Ngan E.S.W., Lui V.C.H. and Sham M.H., Abnormal enteric ganglia development in Sox 10 mouse mutant, Mechanisms of Development. Elsevier, 2005, 122: S177.

Law M.L., Tsang W.H., Ngan E.S.W., Lui V.C.H. and Sham M.H., Abnormal enteric ganglia development in a Sox10 mouse mutant generated by gene targeting , Mechanisms of Development, 15th International Society of Developmental Biologist Congress 2005, Sydney Australia 3-7 September 2005.

Lui V.C.H., Fu M., Poon H.C., Sham M.H., Pachnis V., Hui C.C. and Tam P.K.H., Conditional knockout of PTC1 gene in vagal neural crest cells causes defective ENS development in mice, Development of the Enteric Nervous System: Cells, signals and genes, New York, U.S.A., 26-29 March 2006. 2006.

Lui V.C.H., Cheng W.C., Chen Y., Sham M.H. and Tam P.K.H., Homeobox gene HOXB5 is required in the embryonic development of the enteric nervous system, 52nd Annual International Congress of British Association of Paediatric Surgeons, Dublin, Ireland, 12-15 July 2005.

Lui V.C.H., Leon Y.Y., Garcia-Barcelo M.M., Ganster R.W., Chen B.L.S., Hutson J.M. and Tam P.K.H., Novel RET mutation produces a truncated RET receptor lacking the intracellular signaling domain in a 3-generation family with Hirschsprung Disease, Clinical Chemistry. 2005, 51(8): 1552-1554.

Lui V.C.H., Cheng W.C., Chen Y., Sham M.H. and Tam P.K.H., Perturbation of Hoxb5 signalling in vagal neural crest cells causes defective development of the enteric nervous system, 15th International Society of Developmental Biologists Congress 2005, Sydney, Australia, 3-7 September 2005.

Ngan E.S.W., Lui V.C.H., Lau K.C., Garcia-Barcelo M.M. and Tam P.K.H., Transcriptional profiling of eneteric neural crest cells, Mechanisms of Development. 2005, 122: S179.

Ngan E.S.W., Lui V.C.H., Lau K.C., Garcia-Barcelo M.M., Sham M.H. and Tam P.K.H., Transcriptional profiling of enteric neural crest cells, 15th International Society of Developmental Biologists Congress 2005, Sydney, Australia, 3-7 September 2005.

Researcher : Lui WM

List of Research Outputs

Leung G.K.K., Auyeung K.M., Lui W.M. and Fan Y.W., Emergency placement of a self-expandable covered stent for carotid artery injury during trans-sphenoidal surgery, British Journal of Neurosurgery. 2006, 20(1): 55-57.

Researcher : Luk JMC

Project Title:	Prevention of endotoxin-mediated liver injury by recombinant integrin subunit (RIS), Anti-CD18 Fv and TW-PS22
Investigator(s):	Luk JMC, Fan ST
Department:	Surgery
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2002

Abstract:

The project attempts to exploit new approaches for preventing endotoxin-mediated liver injury in experimental sepsis and ischemia/reperfusion (I/R) animal models.

Project Title:	Target delivery of glyrrhetinic acid to hepatic stellate cells in liver injury
Investigator(s):	Luk JMC, Zhang QS
Department:	Surgery
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004
Completion Date:	07/2006

Abstract:

To synthesize M6P_26-HSA conjugated with GA as a carrier for HSC; to determine the organ distribution of the GA and its localization at HSCs in situ and in vitro; to evaluate the anti-fribotic activities of the neoglycoconjugate GA in HSC.

Project Title:	Development of Proteomic SELDI-based immunoassay for early detection and screening of liver malignancy
Investigator(s):	Luk JMC, Fan S T, Che CM
Department:	Surgery
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	06/2005
Completion Date:	11/2005

Abstract:

Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide, with about half a million new cases and almost as many deaths per year. Early diagnosis has been proven to be important for prognosis. However, there is no reliable diagnosis prior to late stages of disease and no hope for cure except surgery. Objectives & Deliverables: 1. To identify and characterize potential biomarkers for HCC by proteomic technology. 2. To generate monoclonal antibodies directed against biomarkers specific for cirrhotic liver and/or HCC. 3. To develop SELDI-based immuno-diagnostic test for early detection of HCC as well as for disease monitoring.

Project Title:	Aberrant expression of LI-cadherin splicing in hepatocellular carcinoma: pathogenicity and prognostic value
Investigator(s):	Luk JMC
Department:	Surgery
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2005
Completion Date:	06/2006

Abstract:

N/A

Project Title:	Investigating Liver Intestine-Cadherin Function In Hepatocellular Carcinoma
Investigator(s):	Luk JMC, Lee PY, Ng IOL, Fan ST
Department:	Surgery
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	12/2005

Abstract:

Purpose: - The purpose of this study is to investigate the functions and pathogenic roles of a novel cadherin, CDH17, recently identified in HCC, which is found to be a potential disease marker and correlated with poor prognosis. Key issues: - Cadherins are a superfamily of Ca2+-dependent cell adhesion molecules, which are important in mediating adherent junction formation and maintaining tissue integrity. LI-cadherin (CDH17) is involved in the embryonic development of liver and gastrointestinal tract, and functions as an intestinal peptide transporter. However, CDH17 is not detectable in normal adult liver. Our earlier observations, however, have shown that over-expression of LI-cadherin is found in over 80% of HCC, but not in non-cancerous tissues or normal liver tissues from these patients. Moreover, our group has identified an alternative splicing form with exon 7 skipped in the LI-cadherin gene among 50% of the HCC tumors. Expression of the LI-cadherin splice variant in HCC is significantly associated with venous infiltration and early intra-hepatic recurrence of tumor as well as shorter overall survival of HCC patients. Because of its high prevalence and association with poor clinical outcomes, LI-cadherin is suggested to be a potential disease marker for HCC. More interestingly, we did not observe the splice variant in over 100 gastric adenocarcinoma specimens that were tested, indicating that the splice variant is HCC specific. Problems to be addressed: - The functions of the LI-cadherin wild-type form or exon 7-skipped splice variant in HCC remain unknown. Will over-expression of LI-cadherin affect classical E-cadherin expression and function? Does the splice variant have a dominant-negative function to cause cell-cell disintegration, thereby promoting tumorigenesis and cancer metastasis? Our future goal is to establish a mouse model to determine what will happen if CDH17 is forcibly expressed in postnatal and adult liver, when transcription of the gene is normally repressed or silenced in these stages? To address these issues, there is a need to obtain specific antibodies that could differentiate the wild type and splicing forms of LI-cadherin, since the current commercial antibodies failed to detect the exon 7-spliced variant in HCC. The proposed study will also investigate the expression pattern and biological functions of LI-cadherin molecule in HCC using both in vitro culture and xenograft mouse models, to confirm our hypothesis of its pathogenic roles in mediating tumor invasiveness and enhancing the metastatic potentials. Specific Aims: 1. To generate and characterize monoclonal antibodies that could differentiate wild-type and exon 7-spliced form of LI-cadherin molecules; 2. To study and correlate the expression patterns of LI-cadherin and E-cadherin/catenin complexes in HCC specimens of different clinical stages and features; 3. To establish stable transfectants expressing wild-type and splice variants of LI-cadherin, and examine the tumorigenic properties in experimental invasion and intra-hepatic metastasis animal models; 4. To design and characterize anti-sense oligonucleotides to block LI-cadherin function in high metastatic HCC cell lines.

List of Research Outputs

Hui C.K., Lau E., Wu H., Monto A., Kim M., Luk J.M.C., Lau G. and Wright T.L., Fibrosis progression in chronic hepatitis C patients with occult hepatitis b co-infection, J Clin Virol . 2005, 35: 185-192.

Hui C.K., Lau E., Kim M., Monto A., Luk J.M.C., Leung N., Lo C.M., Fan S.T., Wright T.L. and Lau G., Fibrosis progression in patients with recurrent chronic hepatitis C virus and occult hepatitis B co-infection after liver transplantation (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A80.

Hui C.K., Cheung W.W., Zhang H., Au W.Y., Yueng Y.H., Leung A.Y.H., Leung N., Luk J.M.C., Lie A.K.W., Kwong Y.L., Liang R.H.S. and Lau G., Kinetics and risk of de novo hepatitis B infection in HBsAg negative patients undergoing cytotoxic chemotherapy, Gastroenterology. 2006, 131: 59-68.

Hui C.K., Lau E., Monto A., Kim M., Luk J.M.C., Poon R.T.P., Leung N., Lo C.M., Fan S.T. and Lau G., Natural history of patients with recurrent chronic hepatitis C virus and occult hepatitis B co-infection after liver transplanation, AM J Transplanation. 2006, 6(7): 1600-8.

Hui C.K., Cheung W.W., Zhang H., Au W.Y., Yueng Y.H., Leung A.Y.H., Leung N., Luk J.M.C., Lie A.K.W., Kwong Y.L., Liang R.H.S. and Lau G., Rituximab increases the Risk of De Novo hepatitis B infection in Hepatitis B Surface Antigen Negative Patients Undergoing Cytotoxic Chemotherapy, J Gastroenterol and Hepatol. 2006, 21(2): A73.

Hui C.K., Zhan H.Y., Lee N.P., Yueng Y.H., Lu L., Leung N., Wong B.C., Lo C.M., Fan S.T., Luk J.M.C. and Lau G., Upregulation of toll-like receptor 7 is essential for serological clearance of hepatitis B surface antigen in chronic hepatitis B (HBV) infection, Hepatology. 2005, 42(4): 707A-708A, Suppl 1.

Hui C.K., Zhang H., Lee N.W., Lu L., Leung N., Wong B.C.Y., Lo C.M., Fan S.T., Luk J.M.C. and Lau G., Upregulation of toll-like receptor 7 is essential for serological clearance of hepatitis B surface antigen in chronic hepatitis B virus (HBV) infection, Liver International 2005. 2005, Oct: 196.

Lee N.P., Leung K.W., Wo J.Y., Tam P.C., Yeung W.S.B. and Luk J.M.C., Blockage of testicular connexins induced apoptosis in rat seminiferous epithelium, Apoptosis. 2006, 11(7): 1215-1229.

Lee N.P., Tsang S.T.Y., Cheng R.H. and Luk J.M.C., Increased solubility of integrin betaA domain using maltose-binding protein as a fusion tag, Protein PEPT Lett. 2006, 13(5): 431-435.

Lee P.Y., Tong M.K., Leung P.L., Chan V.W.M., Leung S.Y.L., Tam P.C., Chan K.W., Lee C.K.F., Yeung W.S.B. and Luk J.M.C., Kidney claudin-19: Localization in distal tubules and collecting ducts and dysregulation in polycystic renal disease, FEBS Letters. 2006, 580(3): 923-31.

Lee P.Y., Leung K.W., Sham P.C., Lau G., Fan S.T. and Luk J.M.C., Proteomic expression clustering of mouse liver developmental stages (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A218.

Lin M.C., Lee P.Y., Zheng N., Yang P., Wong O.G., Kung H.F., Hui C.K., Luk J.M.C. and Lau G., Tumor necrosis factor-a-induced protein 1 and immunity to hepatitis B virus, World Journal of Gastroenterology. 2005, 11(48): 7564-8.

Luk J.M.C., BioTechniques. 2005.

Luk J.M.C., Brain Research. 2005.

Luk J.M.C., Comparing Serum Alpha-Fetoprotein Level and SELDI-TOF-MS Profiling for Diagnosis of Hepatocellular Carcinoma , Biomedical Proteome Research Center, Yonsei University, Seoul, Korea. 5 October 2005. 2005.

Luk J.M.C., Comparing Serum Alpha-Fetoprotein Level and SELDI-TOF-MS Profiling for Diagnosis of Hepatocellular Carcinoma, The 4th JSH Single topic conference on hepatocellular carcinoma Hoyogo, Japan, 2-3 December 2005 . 2005.

Luk J.M.C., Comparing serum alfa-fetoprotein level and SELDI-TOF-MS profiling for diagnosis of hepatocellular carcinoma, Proteome Society Fall Meeting, Hotel @ MIT, Cambridge, MA, USA, 19 October 2005. 2005.

Luk J.M.C., Chen L., Lam B.K.Y., Ho D.W.Y., Peng J.R., Leng X.S., Hui C.K., Lau G., Yip T.T. and Fan S.T., Comparing serum alpha-fetoprotein level and SELDI-TOF-MS profiling for diagnosis of hepatocellular carcinoma (Abstract), The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2-3 December 2005.

Luk J.M.C., Chen L., Lam B., Ho D., Peng J., Leng J., Leng X., Hui C.K., Lau G., Yip T.T. and Fan S.T., Comparing serum alpha-fetoprotein level and SELDI-TOF-MS profilling for diagnosis of hepatocellular carcinoma. The 4th JSH Single Topic conference on hepatocellular carcinoma. , Hoyogo, Japan. 2005, Dec2-3, 05.

Luk J.M.C., Course Coordinator and Organizer (September 2005 - present), Specialized core module: Surgical Oncology: From laboratory to clinical applications, Faculty of Medicine, The University of Hong Kong. 2005.

Luk J.M.C., Distinguished scientific award, In: Japan Society of Hepatology, 4th Single topic conference on hepatocellular carcinoma. 2005.

Luk J.M.C., Wang X., Garcia-Barcelo M.M., Leung P.P., Lam B.K.Y., Ho D.W.Y., Yu W.C., Hui C.K. and Lau G., Genetic polymorphisms of liver intestine-cadherin CDH17 are associated with alternative mRNA splicing and increased risk of hepatocellular carcinoma (Abstract), Hepatology. 2005, 42(4): 307A-308A Suppl 1.

Luk J.M.C., Gut. 2005.

Luk J.M.C., Wang P.P., Lee C.K.F., Wang J.H. and Fan S.T., Hepatic potential of bone marrow stromal cells: development of in vitro co-culture and intra-portal transplantation models, Journal of Immunological Methods. 2005, 305(1): 39-47.

Luk J.M.C., Zhang Q., Wo J., Leung P.P., Hu M.Y., Lau G. and Fan S.T., Hepatic stellate cell-targeted delivery of 18beta-glycyrrhetinic acid modulates bile duct ligation-induced fibrosis in rat liver, Hepatology. 2005, 42(4): 266A-266A Suppl 1.

Luk J.M.C., Hepatic stellate cell-targeted delivery of 18beta-glycyrrhetinic acid modulates bile duct ligation-induced fibrosis in rat liver, In: 56th Annual Meeting of the AASLD, Moscone Convention Center, San Francisco, California, November 11 15, 2005.. 2005.

Luk J.M.C., Hepatocellular carcinoma proteome of clinical correlations (Invited lecture), Hong Kong - Shanghai International Liver Congress, Shanghai, China, 28 March 2006. 2006.

Luk J.M.C., Intraportal transplantation of bone marrow stromal cell restores liver functions in hepatic injury models (Invited Distiguished Lecture), School of Medical Technology, Jiangzho University, China, 27 March 2006. 2006.

Luk J.M.C., Liver intestine-cadherin splicing and polymorphisms in hepatocellular carcinoma, 10th World Congress on Advances in Oncology and 8th International Symposium on Molecular Medicine. Creta Maris, Hersonissos, Crete, Greece. 13-15 October 2005. 2005.

Luk J.M.C. and Wong K.F., Monoclonal antibodies as targeting and therapeutic agents: prospects for liver transplantation, hepatitis and hepatocellular carcinoma, Clinical Experience of Pharmacology Physiology. 2006, 33 (5-6): 482-488.

Luk J.M.C., Oncoproteomics of hepatocellular carcinoma (Invited Lecture), The 1st International Proteomics Symposium, Hong Kong, 25 - 26 May 2006. 2006.

Luk J.M.C., Fan S.T., Xin Y., Peng J.R. and Leng X.S., Proteomic identification of stress-response heat shock protein markers associated with tumor recurrence in patients with hepatocellular carcinoma (Abstract), The Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A75.

Luk J.M.C., Lam C.T., Siu A.F.M., Lam B.Y.H., Ng I.O.L., Hu M.Y., Che C.M. and Fan S.T., Proteomic profiling of hepatocellular carcinoma in Chinese cohort reveals heat-shock proteins (Hsp27, Hsp70, GRP78) up-regulation and their associated prognostic values, Proteomics . 2006, 6(3): 1049-1057.

Luk J.M.C., Peng J.R., Leng X.S. and Fan S.T., Proteomics and biomarker discovery for hepatocellular carcinoma (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Luk J.M.C., Reviewer, American Journal of Physiology. 2006.

Luk J.M.C., Reviewer, Cancer Investigation. 2006.

Luk J.M.C., Reviewer, FEBS Letters. 2006.

Luk J.M.C., Reviewer, Gut. 2006.

Luk J.M.C., Reviewer, Hepatology. 2006.

Luk J.M.C., Reviewer, Journal of Gastroenterology & Hepatology. 2006.

Luk J.M.C., Reviewer, Journal of Hepatology. 2006.

Luk J.M.C., Reviewer, Oncogene. 2006.

Luk J.M.C., Reviewer, Proteomics. 2006.

Luk J.M.C., Reviewer, Transplantation. 2006.

Luk J.M.C., Seminar on Liver cancer biomarkers (Invited lecture), Fred Hutchinson Cance rResearch Center, Seattle, U..A., 14 March 2006. 2006.

Luk J.M.C., Seminar on Onco-proteomics of hepatocellular carcinoma (Invited lecture), Cold Spring Harbor Laboratory, Long Island, U.S.A., 17 March 2006. 2006.

Luk J.M.C., State-of-the-Art Lecture: Proteomics & biomarkers discovery for HCC, 7th Annual Scientific Meeting of The Centre for the Study of Liver Disease, Conrad Hong Kong, 21 January, 2006.. 2006.

Ren Y., Cao B., Law S.Y.K., Xie Y., Lee P.Y., Cheung C.M., Chen Y., Huang X., Chan H.M., Zhao P., Luk J.M.C., Vande Woude G. and Wong J., Hepatocyte growth factor promotes cancer cell migration and angiogenic factors expression: a prognostic marker of human esophageal squamous cell carcinomas, Clinical Cancer Research. 2005, 11(17): 6190-6197.

Wang Y., Luk J.M.C., Chu A.C.Y., Ikeda K., Man K., Kaneda K. and Fan S.T., TNP-470 blockage of VEGF synthesis is dependent on MAPK/COX-2 signaling pathway in PDGF-BB-activated hepatic stellate cells, Biochemical and Biophysical Research Communications. 2006, 341-(1): 239-244.

Wong K.F., Fan S.T. and Luk J.M.C., Immunochemical characterization of tripterygium wifordii (triptolide, triptonide and synthetic racemic derivatives) immunosupppressive properties in allogenic mixed lymphocyte reaction (Abstract) (Best poster presentation award), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25 - 28 March 2006. 2006.

Wong K.F., Fan S.T. and Luk J.M.C., Immunochemical characterization of tripterygium wilfordii (triptolide, triptonide and synthetic racemic derivatives) immunosuppressive properties in allogenic mixed lymphocyte reaction (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A219.

Yu X.M., Lo C.Y., Chan W.F., Lam K.Y., Leung P. and Luk J.M.C., Increased expression of vascular endothelial growth factor c in papillary thyroid carcinoma correlates with cervical lymph node metastases, Clinical Cancer Research. 2005, 11(22): 8063-8069.

Zender L., Spector M.S., Xue W., Flemming P., Cordon-Cardo C., Silke J., Fan S.T., Luk J.M.C., Wigler M., Hannon G.J., Mu D., Lucito R., Powers S. and Lowe S.W., Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach, Cell. 2006, 125(7): 1253-1267.

Zhang H., Hui C.K., Wong A., Lee N.P., Leung N., Luk J.M.C. and Lau G., Comparison of Real-Time PCR Assays for monitoring Serum HBV DNA Levels During Antiviral Therapy, J Gastroenterol and Hepatol. 2006, 21(2): A140.

Zhang Q., Luk J.M.C., Zhang J. and Tian G.Y., Targeting glycyrrhetinic acid to hepatic stellate cells in treating rat liver fibrosis (in chinese), Zhonghua Gan Zang Bing Za Zhi. 2005, 13(9): 664-667.

Researcher : Lund VJ

List of Research Outputs

Lund V.J., Wei W.I. and Ho W.K., Ethnic variation in sinonasal anatomy on CT-scanning, Rhinology. 2005, 43(3): 210-214.

Researcher : Luo Y

List of Research Outputs

Luo Y., Lo C.M. and Cheung C.K.Y., Cross-sectional study on hepatitis B virus-specific CD4+ T cell immune response after liver transplantation (Abstract), The 2006 Joint International Congress of the International Liver Transplantation Society (ILTS), the European Liver and Intestinal Transplant Association (ELITA), and the Liver Intensive Care Group of Europe (LICAGE), Milan, Italy, 3 - 6 May 2006. Liver Transplantation. 2006, 12: C101.

Researcher : Man K

Project Title:	The anit-cancer effect of FTY720 on liver tumors in vitro and in vivo
Investigator(s):	Man K, Fan ST, Ho JWY
Department:	Surgery
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2004
Completion Date:	07/2005

Abstract:

To investigate the anti-cancer effect of FTY720 on liver tumors in vitro and in vivo by detection of different cell signalling pathways including cell survival, apoptosis, and cell invasion and migration, as well as the comparison of tumor growth and metastasis.

Project Title:	The significance of graft size on tumor recurrence after liver transplantation
Investigator(s):	Man K, Fan ST, Lo CM
Department:	Surgery
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2004

Abstract:

To test the hypothesis that small-for-size grafts are more susceptible to tumor recurrence after liver transplantation in a rat liver transplantation model; to clarify the mechanism of tumor recurrence.

Project Title:	The effect of Rapamycin on ischemia/reperfusion injury in liver transplantation using small-for-size grafts in a cirrhotic rat model - the investigation of the hepatic stellate cell activation and ROCK pathway
Investigator(s):	Man K, Lo CM, Fan ST
Department:	Surgery
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2005
Completion Date:	12/2006

Abstract:

To explore the protective effect of an immunosuppressive drug Rapamycin on ischemia/reperfusion in jury in a rat liver transplantation model using small-for-size grafts and cirrhotic recipients by investigation of the activation of hepatic stellate cells and ROCK pathway.

Project Title:	The significance of graft size on tumor recurrence after liver transplantation
Investigator(s):	Man K
Department:	Surgery
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

N/A

Project Title:	Fat-derived hormone adiponectin as a novel therapy for fatty liver graft injury
Investigator(s):	Man K
Department:	Surgery
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	09/2005

Abstract:

N/A

Project Title:	Fat-derived hormone adiponectin as a novel therapy for fatty liver graft injury
Investigator(s):	Man K, Xu A, Fan ST
Department:	Surgery
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2005

Abstract:

To investigate the protective effect of adiponectin on fatty live-graft in a rat-liver transplant model.

Project Title:	The signifcance of hepatic ischemia/reperfuison injury of small liver remnant on liver tumor growth and metastasis
Investigator(s):	Man K, Lo CM
Department:	Surgery
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2006

Abstract:

Background (key issue and problems being addressed) The surgical stress including hepatic ischemia-reperfusion injury during liver resection promoting liver metastasis has been reported. The activation of local cytokines after partial hepatectomy also accelerated liver tumor growth and promoted distant metastasis. However, previous studies only described the phenomenon without precise investigation of the mechanism. Up to now, there has been no study investigating the impact of hepatic ischemia-reperfusion injury and major hepatectomy on the activation of tumor cell invasion and migration pathways. Small GTPases of the Rho family are pivotal regulators of several aspects of cell behavior, such as cell motility, cell proliferation and apoptosis . The over-expression of Rac, Rho and ROCK (Rho kinase) was considered to be correlated with in vitro tumor cell migration. The hemodynamic stress resulting from hepatic ischemia-reperfusion injury activated hepatic Rac over-expression . However, the effect of hemodynamic force on tumor cell itself has not been studied so far, especially on the aspect of cell invasion and migration pathways. Aim of the study In this study, we aim to investigate the impact of hepatic ischemia-reperfusion injury of small liver remnant after major hepatectomy on liver tumor growth and metastasis, and to explore the underlying molecular mechanism related to tumor cell invasion and migration pathways.

List of Research Outputs

Chua C.W., Lee D.T.W., Ling M.T., Zhou C., Man K., Ho J.W.Y., Wang X. and Wong Y.C., FTY720 and its anticancer effects on androgen independent prostate cancer: an in vivo study using CWR22R xenograft., 10th Research Postgraduate Symposium, Fac. Med, HKU. 2005, 50.

Chua C.W., Lee D.T.W., Ling M.T., Zhou C., Man K., Ho J.C.Y., Chan F.L., Wang X. and Wong Y.C., FTY720, a fungus metabolite, inhibits in vivo growth of androgen-independent prostate cancer, International Journal of Cancer. 2005, 117: 1039-1048.

Ho J.W.Y., Man K., Sun K.W., Lee K.W., Poon R.T.P. and Fan S.T., Effects of a novel immunomodulating agent, FTY720, on tumor growth and angiogenesis in hepatocellular carcinoma, Molecular Cancer Therapeutics. 2005, 4(9): 1430-1438.

Lam S., Man K., Ng T.P., Fan S.T. and Lo C.M., The significance of hepatic stellate cell activation in small-for-size fatty liver graft injury (Abstract), The 11th Congress of the International Liver Transplantation Society, Los Angeles, U.S.A., 20 - 23 July 2005.

Lee K.W., Man K., Ho J.W.Y., Wang X., Poon R.T.P., Xu Y., Ng T.P., Chu A.C.Y., Sun K.W., Ng I.O.L., Sun H.C., Tang Z.Y., Xu R. and Fan S.T., FTY720: a promising agent for treatment of metastatic hepatocellular carcinoma, Clinical Cancer Research. 2005, 11(23): 8458-8466.

Lee K.W., Poon R.T.P., Man K., Guan X.Y. and Fan S.T., Identification of biomarkers for metastatic hepatocellular carcinoma (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Li C., Li Y.X., Law G.L., Man K., Wong W.T. and Lei H., Fast water-exchange Gd³⁺-(DO3A-like) complex functionalized with aza-15-crown-5 showing prolonged residence lifetime in vivo, Bioconjugate Chemistry. 2006, 17(3): 571-574.

Man K., Distinguished Scientific Award - "Significant activation of cell invasion and migration pathways in small-for-size grafts potentially increase tumor recurrence after LDLT", The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2 - 3 December 2005. 2005.

Man K., Zhao Y., Xu A., Lo C.M., Lam K.S., Ng K.T., Ho J.W.Y., Sun C.K. and Lee K.W., FTY720 significantly improves small-for-size fatty liver graft survival, American Journal of Transplantation. 2006, 6(3): 467-476.

Man K., Zhao Y., Xu A., Lo C.M., Lam K.S.L., Ng T.P., Ho J.W.Y., Sun K.W., Lee K.W., Li X. and Fan S.T., Fat-derived hormone adiponectin combined with FTY720 significantly improves small-for-size fatty liver graft survival, American Journal of Transplantation. 2006, 6(3): 467-476.

Man K., Liver injury and liver cancer (Invited Lecture), The 4th China Society of Anti-Cancer Organization Congress, Kunming, China, 20 - 23 October 2005. 2005.

Man K., Liver transplantation using marginal graft - mechanism and treatments (Invited Lecture), Hong Kong Surgical Forum, Hong Kong, 8 - 10 July 2005. 2005.

Man K., Liver transplantation using marginal graft - mechanism of graft injury and therapeutic strategies (Invited Lecture), Zhejiang University, Hangzhou, China, 25 May 2006. 2006.

Man K., Su M., Ng T.P., Lo C.M. and Fan S.T., Rapamycin attenuates liver graft injury in a cirrhotic rat liver transplantation model - the significance of down-regulation of Rho-ROCK pathway (Abstract), The 11th Congress of the International Liver Transplantation Society, Los Angeles, U.S.A., 20 - 23 July 2005.

Man K., Su M., Ng T.P., Lo C.M., Zhao Y., Ho J.W.Y., Sun K.W., Lee K.W. and Fan S.T., Rapamycin attenuates liver graft injury in cirrhotic recipient - the significance of down-regulation of Rho-ROCK-VEGF pathway, American Journal of Transplantation. 2006, 6(4): 697-704.

Man K., Reviewer, Acta Pharmacologica Sincia. 2006.

Man K., Reviewer, British Journal of Surgery. 2006.

Man K., Reviewer, European Journal of Cancer. 2006.

Man K., Reviewer, Gut. 2006.

Man K., Reviewer, Hepatology. 2006.

Man K., Reviewer, Liver. 2006.

Man K., Reviewer, Liver International. 2006.

Man K., Reviewer, Surgery. 2006.

Man K., Reviewer, Transplantation. 2006.

Man K., Reviewer, World Journal of Surgery. 2006.

Man K., Rising Star Research Award - "The significance of graft size on tumor recurrence/metastases after liver transplantation - activation of cell invasion and migration pathways", The 2006 Joint International Congress of the International Liver Transplantation Society (ILTS), the European Liver and Intestinal Transplant Association (ELITA), and the Liver Intensive Care Group of Europe (LICAGE), Milan, Italy, 3 - 6 May 2006. 2006.

Man K., Lo C.M., Ng T.P., Sun K.W. and Fan S.T., Significant activation of cell invasion, migration and angiogenesis pathways in small-for-size grafts may potentially increase tumor recurrence after living donor liver transplantation (Abstract), The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2-3 December 2005.

Man K., Significant activation of cell invasion, migration and angiogenesis pathways in small-for-size grafts may potentially increase tumor recurrence after living donor liver transplantation, 11th International Liver Transplantation Society Conference, LA, July 20-23, 2005. 2005.

Man K., Lo C.M., Ng T.P., Xiao J., Sun K.W., Su M. and Fan S.T., Significant activation of cell invasion, migration and angiogenesis pathways in small-for-size grafts may potentially increase tumour recurrence after living donor liver transplantation (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Man K., Lo C.M., Ng T.P., Ng T.P., Sun K.W. and Fan S.T., Significant activation of cell invasion, migration and angiogensis pathways in small-for-size grafts may potential increase tumor recurrence after living donor liver transplantation (Abstract), The 11th Congress of the International Liver Transplantation Society, Los Angeles, U.S.A., 20 - 23 July 2005.

Man K., Lo C.M., Ng T.P., Sun K.W. and Fan S.T., The significance of acute phase graft injury on tumor recurrence and metastases in living donor liver transplantation (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A204.

Man K., The significance of acute phase injury on late phase tumor recurrence and metastases (Invited Lecture), The 12th Hong Kong International Cancer Congress and The 2nd Annual Scientific Meeting of Centre of Cancer Research, The University of Hong Kong, Hong Kong, 8-10 December 2005. 2005.

Man K., Sun K.W., Liu C.L., Ng T.P., Ho J.W.Y., Poon R.T.P. and Fan S.T., The significance of cell adhesion kinase in recurrence of hepatocellular carcinoma after curative liver resection (Abstract), The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2-3 December 2005.

Man K., Lo C.M., Xiao J.W., Ng T.P., Ng I.O.L., Sun K.W., Cheng Q. and Fan S.T., The significance of graft size on tumor recurrence/metastases after liver transplantation – Activation of cell invasion and migration pathways (Abstract), The 2006 Joint International Congress of the International Liver Transplantation Society (ILTS), the European Liver and Intestinal Transplant Association (ELITA), and the Liver Intensive Care Group of Europe (LICAGE), Milan, Italy, 3 - 6 May 2006. Liver Transplantation. 2006, 12: C30.

Man K., Young Investigator Award - "Significant activation of cell invasion, migration and angiogenesis pathways in small-for-size grafts may potentially increase tumor recurrence after living donor liver transplantation", The 11th Annual Congress of the International Liver Transplantation Society, Los Angeles, U.S.A., 20 - 23 July 2005. 2005.

Poon R.T.P., Lee K.W., Yuen P.W., Ling M.T., Wang X., Wong Y.C., Guan X.Y., Man K. and Fan S.T., Id-1 promotes angiogenesis in hepatocellular carcinoma through HIF-1a-mediated VEGF upregulation (Abstract), The 97th Annual Meeting of the American Association of Cancer Research, Washington D.C., U.S.A., 1 - 5 April 2006.

Wang Y., Luk J.M.C., Chu A.C.Y., Ikeda K., Man K., Kaneda K. and Fan S.T., TNP-470 blockage of VEGF synthesis is dependent on MAPK/COX-2 signaling pathway in PDGF-BB-activated hepatic stellate cells, Biochemical and Biophysical Research Communications. 2006, 341-(1): 239-244.

Xu X., Man K., Zheng S.S., Liang T.B., Lee K.W., Ng T.P., Fan S.T. and Lo C.M., Attenuation of acute phase shear stress by somatostatin improves small-for-size liver graft survival, Liver Transplantation. 2006, 12(4): 621-627.

Zhou C., Ling M.T., Lee K.W., Man K., Wang X. and Wong Y.C., FTY720, a fungus metabolite, inhibits invasion ability of androgen-independent prostate cancer cells through inactivation of RhoA-GTPase, Cancer Letters. 2006, 233: 36-47.

Researcher : Miao X

List of Research Outputs

Lau K.C., Garcia-Barcelo M.M., Leon Y.Y., So M.T., Miao X., Ngan E.S.W., Lui V.C.H., Cass D.T., Croaker G.D.H. and Tam P.K.H., Evaluation of thyroid transcription factor 1 (TTF-1) as a Hirschsprung's disease (HSCR) locus by mutation analysis, 39th Annual Meeting of the Pacific Association of Pediatric Surgeons, Taipei, Taiwan, 14-18 May 2006.

Tan W., Miao X., Wang L., Yu C., Xiong P., Liang G., Sun T., Zhou Y., Zhang X., Li H. and Lin D., Significant increase in risk of gastroesophageal cancer is associated with interaction between promoter polymorphisms in thymidylate synthase and serum folate status, Carcinogenesis. 2005, 26(8): 1430-1435.

Zhang X., Miao X., Tan W., Ning B., Liu Z., Hong Y., Song W., Guo Y., Zhang X., Shen Y., Qiang B., Kadlubar F.F. and Lin D., Identification of functional genetic variants in cyclooxygenase-2 and their association with risk of esophageal cancer, Gastroenterology. 2005, 129(2): 565-576.

Researcher : Ng KKC

List of Research Outputs

Chan F.S.Y., Ng K.K.C., Poon R.T.P., Yuen J.H.F. and Fan S.T., Comparison of radiofrequency ablation and hepatic re-resection for intrahepatic recurrent hepatocellular carcinoma (Abstract), The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2-3 December 2005.

Lam C.M., Yong J.L., Chan O.O., Ng K.K.C., Poon R.T.P., Liu C.L., Lo C.M. and Fan S.T., Better survival in female patients with hepatocellular carcinoma: oral contraceptive pills related?, Journal of Clinical Gastroenterology. 2005, 39(6): 533-539.

Ng K.K.C., Associate Consultant, Queen Mary Hospital, Hospital Authority, Hong Kong. 2006.

Ng K.K.C., Poon R.T.P., Chan F.S.Y., Yuen J.H.F., Tso W.K. and Fan S.T., Comparison of radiofrequency ablation and hepatic re-resection for intrahepatic recurrent hepatocellular carcinoma (Oral Presentation), The 106th Annual Congress of Japan Surgical Society, Tokyo, Japan, 29-31 March 2006.

Ng K.K.C., Poon R.T.P., Lam C.M., Yuen J.H.F., Tso W.K. and Fan S.T., Efficacy and safety of radiofrequency ablation for perivascular hepatocellular carcinoma without hepatic inflow occlusion, British Journal of Surgery. 2006, 93(4): 440-447.

Ng K.K.C. and Fan S.T., General Surgery Review. Makary MA (ed) Washington, D.C.: Ladner-Drysdale. 2004: 386, British Journal of Sugery. 2005, 92: 898.

Ng K.K.C., Lo C.M., Chan S.C. and Fan S.T., Increasing applicability of liver transplantation over 13 years - a single institution experience (Oral Presentation), The Annual Scientific Meeting of the Hong Kong Society of Transplantation, Hong Kong, 2 April 2006.

Ng K.K.C., Intraoperative radiofrequency ablation for malignant liver tumos (Invited Lecture), The 2nd International Symposium on Contrast Enhanced US and Interventional US, School of Oncology of Peking University and Peking Union Hospital, Beijing, China, 9 - 10 April 2006. 2006.

Ng K.K.C. and Poon R.T.P., Radiofrequency ablation for malignant liver tumor, Surgical Oncology. 2005, 14(1): 41-52.

Ng K.K.C., Poon R.T.P., Lo C.M., Yuen J.H.F., Tso W.K. and Fan S.T., Recurrence pattern and survival outcome after radiofrequency ablation of hepatocellular carcinoma (Abstract), The 16th World Congress of the International Association of Surgeons and Gastroenterologists, Madrid, Spain, 25 - 27 May 2006.

Ng K.K.C., Reviewer, Asian Journal of Surgery. 2006.

Ng K.K.C., Reviewer, British Journal of Radiology. 2006.

Ng K.K.C., Reviewer, Cytokine. 2006.

Ng K.K.C., Reviewer, Digestive Diseases and Sciences. 2006.

Ng K.K.C., Reviewer, European Surgical Research. 2006.

Ng K.K.C., Reviewer, Hong Kong Medical Journal. 2006.

Ng K.K.C., Reviewer, Journal of Gastroenterology and Hepatology. 2006.

Ng K.K.C., Reviewer, Liver International. 2006.

Ng K.K.C., Reviewer, Surgical Practice of the College of Surgeons of Hong Kong. 2006.

Ng K.K.C., Reviewer, Urology. 2006.

Ng K.K.C., Reviewer, World Journal of Surgery. 2006.

Ng K.K.C., Lam C.M., Poon R.T.P., Shek T.W.H., Ho D.W.Y. and Fan S.T., Safety limit of large-volume hepatic radiofrequency ablation in a rat model, Archives of Surgery. 2006, 141(3): 252-258.

Ng K.K.C., Law W.L., Lee Y.M., Choi H.K., Seto C.L. and Ho J.W.C., Self-expanding metallic stent as a bridge to surgery versus emergency resection for obstructing left-sided colorectal cancer: a case-matched study, Journal of Gastrointestinal Surgery. 2006, 10(6): 798-803.

Ng K.K.C., Silver Prize Award - "Survival analysis of patients with transplantable hepatocellular carcinoma: an implication for salvage transplantation", The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2-3 December 2005. 2005.

Ng K.K.C., Poon R.T.P., Lo C.M., Liu C.L. and Fan S.T., Survival analysis of patients with transplantable hepatocellular carcinoma: an implication for salvage transplantation (Abstract), The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2-3 December 2005.

Ng K.K.C., Poon R.T.P., Lo C.M., Liu C.L., Lam C.M. and Fan S.T., Survival analysis of patients with transplantable recurrent hepatocellular carcinoma: an implication for salvage liver transplantation (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Ng K.K.C., The role of laparoscopic surgery in the management of liver malignancy (Abstract), Hong Kong Surgical Forum, Hong Kong, 13 - 14 January 2006.

Ng K.K.C., The role of laparoscopic surgery in the management of liver malignancy (Abstract), The 11th Joint Shanghai/Hong Kong Surgical Convention, Shanghai, China, 9 - 11 July 2006.

Researcher : Ng TP

List of Research Outputs

Lam S., Man K., Ng T.P., Fan S.T. and Lo C.M., The significance of hepatic stellate cell activation in small-for-size fatty liver graft injury (Abstract), The 11th Congress of the International Liver Transplantation Society, Los Angeles, U.S.A., 20 - 23 July 2005.

Lee K.W., Man K., Ho J.W.Y., Wang X., Poon R.T.P., Xu Y., Ng T.P., Chu A.C.Y., Sun K.W., Ng I.O.L., Sun H.C., Tang Z.Y., Xu R. and Fan S.T., FTY720: a promising agent for treatment of metastatic hepatocellular carcinoma, Clinical Cancer Research. 2005, 11(23): 8458-8466.

Man K., Zhao Y., Xu A., Lo C.M., Lam K.S.L., Ng T.P., Ho J.W.Y., Sun K.W., Lee K.W., Li X. and Fan S.T., Fat-derived hormone adiponectin combined with FTY720 significantly improves small-for-size fatty liver graft survival, American Journal of Transplantation. 2006, 6(3): 467-476.

Man K., Su M., Ng T.P., Lo C.M. and Fan S.T., Rapamycin attenuates liver graft injury in a cirrhotic rat liver transplantation model - the significance of down-regulation of Rho-ROCK pathway (Abstract), The 11th Congress of the International Liver Transplantation Society, Los Angeles, U.S.A., 20 - 23 July 2005.

Man K., Su M., Ng T.P., Lo C.M., Zhao Y., Ho J.W.Y., Sun K.W., Lee K.W. and Fan S.T., Rapamycin attenuates liver graft injury in cirrhotic recipient - the significance of down-regulation of Rho-ROCK-VEGF pathway, American Journal of Transplantation. 2006, 6(4): 697-704.

Man K., Lo C.M., Ng T.P., Sun K.W. and Fan S.T., Significant activation of cell invasion, migration and angiogenesis pathways in small-for-size grafts may potentially increase tumor recurrence after living donor liver transplantation (Abstract), The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2-3 December 2005.

Man K., Lo C.M., Ng T.P., Xiao J., Sun K.W., Su M. and Fan S.T., Significant activation of cell invasion, migration and angiogenesis pathways in small-for-size grafts may potentially increase tumour recurrence after living donor liver transplantation (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Man K., Lo C.M., Ng T.P., Ng T.P., Sun K.W. and Fan S.T., Significant activation of cell invasion, migration and angiogensis pathways in small-for-size grafts may potential increase tumor recurrence after living donor liver transplantation (Abstract), The 11th Congress of the International Liver Transplantation Society, Los Angeles, U.S.A., 20 - 23 July 2005.

Man K., Lo C.M., Ng T.P., Sun K.W. and Fan S.T., The significance of acute phase graft injury on tumor recurrence and metastases in living donor liver transplantation (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A204.

Man K., Sun K.W., Liu C.L., Ng T.P., Ho J.W.Y., Poon R.T.P. and Fan S.T., The significance of cell adhesion kinase in recurrence of hepatocellular carcinoma after curative liver resection (Abstract), The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2-3 December 2005.

Man K., Lo C.M., Xiao J.W., Ng T.P., Ng I.O.L., Sun K.W., Cheng Q. and Fan S.T., The significance of graft size on tumor recurrence/metastases after liver transplantation – Activation of cell invasion and migration pathways (Abstract), The 2006 Joint International Congress of the International Liver Transplantation Society (ILTS), the European Liver and Intestinal Transplant Association (ELITA), and the Liver Intensive Care Group of Europe (LICAGE), Milan, Italy, 3 - 6 May 2006. Liver Transplantation. 2006, 12: C30.

Xu X., Man K., Zheng S.S., Liang T.B., Lee K.W., Ng T.P., Fan S.T. and Lo C.M., Attenuation of acute phase shear stress by somatostatin improves small-for-size liver graft survival, Liver Transplantation. 2006, 12(4): 621-627.

Researcher : Ng WM

List of Research Outputs

Ho W.K. and Ng W.M., Schwannoma of the larynx , ENT Journal. 2005, 84(9): 554-555.

Ho W.K., Lo S.D. and Ng W.M., Schwannoma of the larynx, Ear Nose Throat J. 2005, 84: 336-337.

Ho W.K., Lo S.D.C. and Ng W.M., Schwannoma of the larynx, Ear, Nose & Throat Journal. 2005, 84: 9.

Lam P.K.Y., Ho W.K., Ho A.C., Ng W.M., Yuen P.W. and Wei W.I., Long-term performance of indwelling tracheoesophagel speaking valves in Chinese patients undergoing laryngectomy, Arch Otolaryngol Head Neck Surg. 2005, 131: 954-8.

Ng W.M. and Li K.H., Broken needles, Lancet 2005. 2005, 366.

Ng W.M. and Wei W.I., Elimination of palatal fistual after the maxillary swing procedure, Head Neck . 2005, 27: 608-612.

Ng W.M., Lam P.K.Y. and Wong B.Y., Insertion of Provox2 voice prosthesis using the anterograde technique immediately after the secondary tracheoesophageal puncture, J Laryngol Otol. 2005, 119: 988-990.

Ng W.M. and Wei W.I., Quality of Life of Nasopharyngeal Carcinoma Patients Treated with Nasopharyngectomy, Arch Otolaryngol Head Neck Surg. 2006, 132: 309-316.

Ng W.M. and Wei W.I., Quality of life of patients with recurrent nasopharyngeal carcinoma treated with nasopharyngectomy using the maxillary swing approach, Archives of Otolaryngology, Head and Neck Surgery. American Medical Association, 2006, 132: 309-316.

Ng W.M., Training model for end-to-side microvascular anastomosis in rat, Surgical Practice. Hong Kong, 2006, 10: 114-116.

Researcher : Ngai PP

List of Research Outputs

Yang Z., Lau C.K., Ngai P.P., Ho D.W.Y., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Delayed immunosuppression induces long-term liver allograft survival through interleukin-10 (IL-10) dependent manner (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Yang Z., Lau C.K., Ngai P.P., Ho D.W.Y., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Short-term cardiotrophin-1 (CT-1) rescues marginal cirrhotic liver remnant after major hepatectomy without increasing the risk of tumor recurrence (Oral Presentation), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A92.

Yang Z., Ngai P.P., Lau C.K., Tam K.H., Ho D.W.Y., To J.Y.T., Poon R.T.P. and Fan S.T., Transient production of interleukin-10 (IL-10) by residual macrophages is crucial for the ischemia/reperfusion injury and long-term allograft survival in liver transplantation (Oral Presentation), The 8th International Congress of the Cell Transplant Society, Milan, Italy, 24 - 26 May 2006.

Researcher : Ngan ESW

Project Title:	Sonic hedgehog (Shh) signaling in the enteric neural crest cells
Investigator(s):	Ngan ESW, Sham MH, Lui VCH, Tam PKH
Department:	Surgery
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2005
Completion Date:	12/2006

Abstract:

The main objectives of this project are: 1) To investigate the effect of Shh on the expression profiles of BMP-2 and BMP-4 in mouse embryonic gut. 2) To study the interplay between Shh/BMPs and GDNF signaling in NCC migration. The results of this basic research would provide better understanding of the process of ENS development. This data could further extend the knowledge base regarding the etiology and our understanding of Hirschsprung's disease in human.

Project Title:	Novel Function(s) of Prokineticins in Neural Crest Stem Cells
Investigator(s):	Ngan ESW, Lui VCH, Tam PKH
Department:	Surgery
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2006

Abstract:

The mammalian enteric nervous system (ENS) is derived from the neural crest cells (NCC) which enter the foregut and colonize the entire wall of gastrointestinal tract (1). In mice, NCCs reach foregut at approximately embryonic day 9.4 (E9.5) and finish the colonization by ~E14.5. Numerous gut mesenchyme/mucosa-derived factors and their receptors on NCC are found to be crucial for NCC proliferation, differentiation and migration. They are glial cell-line derived neurotrophic factor (GDNF) and its receptors (RET, GFRA1)(2); endothelin 3 (EDN3) and its receptor (EDNRB)(3); sonic hedgehog (Shh) and its receptor (Ptc)(4). A delicate balance between these signals is a prerequisite for the proper regulation of NCCs during ENS development. Failure to completely colonize the gut results in the absence of enteric ganglia as seen in Hirschsprung’s disease in human.. Prokineticin –1 and -2 (Prok-1 and Prok-2), also referred to endocrine gland derived vascular endothelial growth factor (EG-VEGF) and Bv8, respectively, are structurally related and belong to a newly identified family of secreted proteins, AVIT protein family. These proteins are distributed widely in mammalian tissues. Prok-1 mRNA expression has been described in a variety of tissues, in steroidogenic glands such as the ovary, testis, adrenal gland and placenta, but also in the brain, colon, skeletal muscle, small intestine, spleen, thymus liver, bladder, prostate and uterus(5,6) . Prok-2, on the other hand, shows the highest expression in testis, colon, brain and peripheral blood leukocytes(7,8). These two prokineticins are known to bind to two closely related G protein-coupled receptors, PK-R1 and PK-R2. Receptor activation leads to mobilization of calcium, stimulation of phosphoinositide turnover, and activation of p44/p42 MAPK signaling pathways. Within distinct contexts, the receptors are likely differentially regulated and distinct expression patterns of Prok receptors were observed in various tissues. In the adrenal gland, only PK-R1 was detected. In the ovary, follicular cells predominantly express PK-R1, whereas corpus luteum-derived cells express high levels of both PK-R1 and PK-R2. Similarly, these two receptors are also co-existing in endometrium, but at different expression level. Therefore, it is believed that prokineticins may have different angiogenic as well as non-angiogenic functions in different tissues via acting on either PK-R1 or PK-R2. However, the exact role(s) of PK-R1 and PK-R2 remains unclear. A new appreciation for the intricacy of peptidergic GPCRs is developing, as the ligands for orphan receptors are identified and as distinct signaling and functional responses for multiple ligands and oligomerized receptors are demonstrated. Thus, the distinct or overlapping expression of prokineticins and the possible heteroligomerization of receptors may increase the functional complexity of this system (8,9). It is currently known that prokineticins possess diverse biological functions: they promote angiogenesis in ovary and testis; induce proliferation, migration and fenestration of endothelial cells derived from adrenal gland ; support neuronal survival; cause hyperalgesia of skin; promote contraction of gastrointestinal smooth muscle; and control pain sensation and behavioral circadian rhythms(8,9). More recently, these two receptors were also found in human and mouse hematopoietic stem cells and specific mature blood cells, including lymphocytes. Prokineticins can modulate growth, survival, and function of cells of the innate and adaptive immune systems, possibly through autocrine or paracrine signaling mechanisms(7). Given the reported expression patterns and activities of the mammalian orthologs in brain, reproductive tract, and cells of the immune system, the molecules seem to have subserved similar functions across evolution. In addition to being the angiogenic factors, prokineticins would be the universal survival/mitogenic factors for various cells including endothelial cells, neuronal cells, lymphocytes as well as the hematopietic stem cells. Noteworthy, prokineticins and their receptors were detected in mouse embryo as early at E7, the role(s) of these factors during embryonic development still remains to be disclosed. Our preliminary data: It is known that prokineticin-1 is expressed in mouse and human small intestine and colon. Using antibody specific to Prok-1 to perform the immunohistochemistry study, we found that Prok-1 protein is expressed in the mucosa and enteric neuronal plexus of the gut in the adult mouse. The presence of Prok-1 in neuronal plexus was subsequently confirmed by colocalization study with the neuronal marker, Tuj1 (Appendix I, Figure 1g-i). In embryonic stage, it is highly expressed in the mucosa (E12.5 and E15.5) and forms a concentration gradient across the radius of the embryonic gut (Appendix I, Figure 1a-f). Subsequent RT-PCR analysis also showed that NCCs do not express endogenous Prok-1 (data not shown). A physiological effect of Prok-1 is dependent on the presence of the ligand and the receptor, so we have also examined the expression of the receptors, PK-R1 and PK-R2. Expression study using RT-PCR showed that the PK-R1, but not PK-R2, is expressed in NCCs isolated from E11.5 embryonic gut (Appendix I, Figure 2A). Localization of PK-R1 receptor using in situ hybridization further demonstrated the existence of PK-R1 in the NCCs and NCC derived enteric neurons of the embryonic guts (E10.5-E17.5). The signal is specific because there is no fluorescent signal detected when sense probe was used (Ctrl, Appendix I, Figure 2B). Taken together, it is believed that Prok-1, probably like GDNF, EDN3 and Shh, acts as mesenchyme/mucosa-derived factors and mediate the proliferation or differentiation of NCCs during ENS development. On the other hand, it may also act as a survival factor for the enteric neurons in the adult gut, via an autocrine/paracrine mechanism. Thus, we hypothesize that Prok-1 provides an additional layer of signaling refinement to maintain survival/proliferation of NCCs and mature neurons of the developing and mature ENS, respectively. The aim of this proposed project is to elucidate the physiological role(s) of prokineticins in ENS and during its development. Objective 1: To study the temporal and spatial expression patterns of prokineticins (Prok-1 and Prok-2) and their receptors in mouse gut during ENS development. The information obtained would give a hint to delineate the potential physiological functions of these molecules. Objective 2: To elucidate the mitogenic/neuroprotective properties of prokineticins on NCCs and NCC derived neurons. The functions of prokineticins in NCCs will be examined directly using the in vitro NCC culture system. Objective 3: To examine the effect of prokineticins on the differentiation capacity of NCCs. Reference 1. D. Newgreen, H. M. Young, Pediatr. Dev. Pathol. 5, 329 (2002). 2. A. Barlow, E. de Graaff, V. Pachnis, Neuron 40, 905 (2003). 3. G. M. Kruger et al., Neuron 40, 917 (2003). 4. M. Fu, V. C. Lui, M. H. Sham, V. Pachnis, P. K. Tam, J. Cell Biol. 166, 673 (2004). 5. J. LeCouter et al., Nature 412, 877 (2001). 6. E. S .Ngan et al., Endocrinology Oct 6; [Epub ahead of print] (2005) . 7. J. LeCouter, C. Zlot, M. Tejada, F. Peale, N. Ferrara, Proc. Natl. Acad. Sci. U. S. A 101, 16813 (2004). 8. A. Kaser, et al., EMBO reports 4,469 (2003) 9. J. LeCouter, R. Lin, N. Ferrara Ann. N.Y. Acad. Sci 1014: 50(2004).

List of Research Outputs

Lau K.C., Garcia-Barcelo M.M., Leon Y.Y., So M.T., Miao X., Ngan E.S.W., Lui V.C.H., Cass D.T., Croaker G.D.H. and Tam P.K.H., Evaluation of thyroid transcription factor 1 (TTF-1) as a Hirschsprung's disease (HSCR) locus by mutation analysis, 39th Annual Meeting of the Pacific Association of Pediatric Surgeons, Taipei, Taiwan, 14-18 May 2006.

Law M.L., Tsang W.H., Ngan E.S.W., Lui V.C.H. and Sham M.H., Abnormal enteric ganglia development in Sox 10 mouse mutant, Mechanisms of Development. Elsevier, 2005, 122: S177.

Law M.L., Tsang W.H., Ngan E.S.W., Lui V.C.H. and Sham M.H., Abnormal enteric ganglia development in a Sox10 mouse mutant generated by gene targeting , Mechanisms of Development, 15th International Society of Developmental Biologist Congress 2005, Sydney Australia 3-7 September 2005.

Law M.L., Tsang W.H., Ngan E.S.W., Lui V.C.H. and Sham M.H., The Role of SOX10 in the Enteric Neural Crest Development, 10th Research Postgraduate Symposium, Faculty of Medicine, HKU, December 3, 2005 . 2005.

Ngan E.S.W., Lee K.Y., Yeung W.S.B., Ngan H.Y.S., Ng E.H.Y. and Ho P.C., Endocrine Gland-Derived Vascular Endothelial Growth Factor is expressed in human peri-implantation endometrium, but not in endometrial carcinoma, Endocrinology. 2006, 147: 88-95.

Ngan E.S.W., Lui V.C.H., Lau K.C., Garcia-Barcelo M.M. and Tam P.K.H., Transcriptional profiling of eneteric neural crest cells, Mechanisms of Development. 2005, 122: S179.

Ngan E.S.W., Lui V.C.H., Lau K.C., Garcia-Barcelo M.M., Sham M.H. and Tam P.K.H., Transcriptional profiling of enteric neural crest cells, 15th International Society of Developmental Biologists Congress 2005, Sydney, Australia, 3-7 September 2005.

Yam J.W.P., Chan K.W., Ngan E.S.W. and Hsiao W.L., Genomic structure, alternative splicing and tissue expression of rFrp/sFRP-4, the rat frizzled related protein gene., Gene. 2005, 357: 55-62.

Researcher : Patil NG

Project Title:	Audit of deaths and complications in surgical patients admitted to university surgical unit
Investigator(s):	Patil NG
Department:	Surgery
Source(s) of Funding:	Other Funding Scheme
Start Date:	01/1992

Abstract:

To assess: (1) quality and standard of care; (2) educational value; (3) reporting of complications; (4) incidence and prevalence of life threatening surgical conditions; (5) improvements in surgical techniques, investigation procedures, clinical practice and infrastructure.

Project Title:	Risk factors for inguinal hernia in adults: a case-control study
Investigator(s):	Patil NG, Lau H
Department:	Surgery
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002

Abstract:

To evaluate and identify the risk factors for the development of inguinal hernia in adults.

Project Title:	Risk factors for hernia development in patients receiving continuous ambulatory peritoneal dialysis (CAPD)
Investigator(s):	Patil NG, Lau H
Department:	Surgery
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Abstract:

To evaluate the incidence of and identify the risk factors for the development of hernia in patients who are undergoing CAPD.

List of Research Outputs

Chan L.C. and Patil N.G., Monograph 2: Problem-Based Learning (PBL) Everything you want to know and are not afraid to ask. Hong Kong, Institue of Medical and Health Sciences Education, 2006, 1-48.

Chan L.C., Lee P.P.W. and Patil N.G., Monograph 2: Problem-based Learning (PBL): Everything you want to know and are not afraid to ask, PBL - Its role and place in the medical curriculum. Institute of Medical and Health Scienced Education, HKU, 2006, 7-11.

Goldberg M.A., Sharman Z., Bell B., Ho K. and Patil N.G., E-health and the Universitas 21 organization: 4. Professional portability, Journal of Telemedicine and Telecare. 2005, 11: 230-233.

Lau H., Patil N.G. and Yuen W.K., Day-case endoscopic totally extraperitoneal inguinal hernioplasty versus open Lichtenstein hernioplasty for unilateral primary inguinal hernia in males: a randomized trial, Surgical Endoscopy. 2006, 20(1): 76-81.

Lau H., Lo C.Y., Patil N.G. and Yuen W.K., Early versus delayed-interval laparoscopic cholecystectomy for acute cholecystitis: a metaanalysis, Surgical Endoscopy. 2006, 20(1): 82-87.

Lau H., Patil N.G. and Yuen W.K., Is endoscopic totally extraperitoneal hernioplasty justified for the repair for groin hernia in female patients?, Surgical Endoscopy. 2005, 19(12): 1544-1548.

Patil N.G., Academic Surgery in crisis?, Association of University Surgeons of Asia 7th Scientific Meeting in conjunction with 15th Asian Surgical Congress, Pattaya, Thailand, 20-23 July 2005.

Patil N.G., External Examiner, School of Medicine, Universiti Malaysia Sabah, Sabah, Malaysia, 14-18 May 2006. 2006.

Patil N.G., Honorary Consultant in Surgery, Hong Kong Sanatorium & Hospital, Hong Kong. 2006.

Patil N.G., Honorary Consultant in Surgery, Tung Wah Hospital, Queen Mary Hospital. 2006.

Patil N.G., Invited Speaker, One World Medicine, An International Association for Medical Education, Amsterdam, Netherland, 30 August - 3 September 2005. 2005.

Schmidt K., Rees C., Greenfield S., Wearn A.M., Dennis J., Patil N.G., Amri H. and Boon H., Multischool, international survey of medical students' attitudes toward "Holism", Academic Medicine. 2005, 80(10): 955-963.

Tiwari A.F.Y., Chan S.S.C., Wong E.M.Y., Wong C.N., Chui Y.Y., Wong A. and Patil N.G., The effect of problem-based learning on students' approaches to learning in the context of clinical nursing education, Nurse Education Today. Elsevier, 2006, 26: 430-438.

Wong J.G.W.S., Patil N.G., Beh S.L., Cheung E.P.T., Wong V., Chan L.C. and Mak-Lieh F., Cultivating psychological well-being in Hong Kong's future doctors, Medical Teacher. 2005, 27(8): 715-9.

Researcher : Poon HC

List of Research Outputs

Lui V.C.H., Fu M., Poon H.C., Sham M.H., Pachnis V., Hui C.C. and Tam P.K.H., Conditional knockout of PTC1 gene in vagal neural crest cells causes defective ENS development in mice, Development of the Enteric Nervous System: Cells, signals and genes, New York, U.S.A., 26-29 March 2006. 2006.

Researcher : Poon RTP

Project Title:	Prospective randomized trial of radiofrequency ablation versus hepatic resection for hepatocellular carcinoma <= 5 cm
Investigator(s):	Poon RTP, Fan ST
Department:	Surgery
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	12/2002

Abstract:

The project attempts to compare the immediate and long-term outcomes between radiofrequency ablation (RFA) nad hepatic resection for patients with hepatocellular carcinoma (HCC) less than or equal to 5 cm.

Project Title:	Genetic analysis of epidermal growth factor receptor (EGFR) in hepatocellular carcinoma (HCC) and anti-cancer effect of the selective EGFR-tyrosine kinase inhibitor Iressa (ZD1839) in HCC cell lines
Investigator(s):	Poon RTP, Ho JWY
Department:	Surgery
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003
Completion Date:	10/2005

Abstract:

To analyse the genetic expression of EGFR and its receptor family in HCC, and to evaluate the anti-cancer effect of EGFR tyrosine kinase inhibitor ZD1839 (Iressa) in HCC.

Project Title:	Effects of combined drug therapy using gleveec and FTY720 on angiogenesis and tumor growth in hepatocellular carcinoma
Investigator(s):	Poon RTP, Man K, Ho JWY
Department:	Surgery
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004
Completion Date:	04/2006

Abstract:

To study the effect of combined drug therapy using Gleveec and FTY720 on tumor angiogenesis and tumor growth in hepatocellular carcinoma (HCC) using a nude mice model.

Project Title:	Identification of Rac as a novel therapeutic target in hepatocellular carcinoma metastasis
Investigator(s):	Poon RTP, Lee KW
Department:	Surgery
Source(s) of Funding:	Small Project Funding
Start Date:	09/2005
Completion Date:	08/2006

Abstract:

Hepatocellular carcinoma (HCC) is a highly malignant tumor which is characterized by active neovascularization (Poon et al., Ann. Surg., 2001;233:227-35). It is the fifth most common malignancy worldwide (Kuper et al., Hepatology, 2001;34:714-8; Tang, World J. Gastroenterol., 2001;7:445-54). The poor prognosis of HCC is commonly associated with propensity for vascular invasion and metastasis (Tang, World J. Gastroenterol., 2001;7:445-54). It has been previously shown that angiogenesis makes significant contribution to tumor growth, invasiveness, and metastatic potential of HCC (Poon et al., J. Clin. Oncol., 2001,19:1207-25; Sugimachi et al., Surgery, 2002;131:S135-41; Tanigawa et al., Hepatology, 1997;26:1216-23). The degree of angiogenesis in a tumor is the net result reflecting complex interactions of various proangiogenic factors and antiangiogenic factors, secreted by tumor cells, vascular endothelial cells, and infiltrating cells. Switching to angiogenic phenotype involves the up-regulation of proangiogenic factors, down-regulation of antiangiogenic factors, or both. Thus far, there are limited data on the role of various proangiogenic factors in HCC (Poon et al., Ann. Surg., 2003; 238:9-28). Vascular endothelial growth factor (VEGF) is a potent angiogenic factor that plays a central role in angiogenesis in various cancer types (Toi et al., Lancet Oncol., 2001;2:667-73). A previous study from our group has reported that VEGF is a potent angiogenic factor leading to HCC invasiveness (Ng et al., Am. J. Clin. Pathol., 2001;116:838-45). However, the mechanism by which VEGF is regulated is far from understood. Understanding the underlying regulatory mechanism of VEGF allows the development of novel therapies targeting at the inhibition of HCC invasiveness so that patients’ survival can be improved. Cell motility is an important factor in the progression and metastasis of HCC. Family members of the Rho-like GTPases, including Cdc42, Rac1, and RhoA, have been found to play important roles in distinct actin cytoskeleton changes that were required for cell adhesion, migration, and invasion (Hall, Science, 1998;279:509-14) Recently, we first demonstrated the significance of Rac signaling pathway in HCC cell motility (Lee et al., Carcinogenesis, 2005;26:681-7). An elevated Rac-GTP level was found in the metastatic HCC cell line compared with the primary HCC cell line. The higher level of Rac-GTP accompanied with activated SAPK/JNK pathway was correlated with HCC cell motility (Lee et al., Carcinogenesis, 2005;26:681-7). Apart from its effect on cell motility, Rac activation may play a role in angiogenesis. This hypothesis is based on the observation that there was a significant correlation between the decrease in Rac protein level and decrease in VEGF and CD34 protein expression in HCC metastatic tumor model upon administration of a novel immunosuppressive drug, FTY720 (Lee et al., Clin. Cancer Res., in press).This possible interaction between Rac and VEGF has been recently supported by our in vitro experiment showing upregulation of VEGF expression upon transfection of Rac-dominant active into Hep3B cell. To my knowledge, this is the first study showing a direct link between Rac and VEGF expression. Given a central role of VEGF in cancer angiogenesis, it is of great interest to elucidate whether Rac activation promotes cancer angiogenesis by interacting with VEGF expression. In this study, we hypothesized that Rac might promote HCC metastasis by acting as an angiogenic factor through upregulation of VEGF expression. Although the angiogenic role of Rac has been suggested, the underlying mechanism has not been studied so far. Understanding its molecular mechanism allows future development of novel therapies targeting angiogenesis in HCC. The long term goal of this project is to elucidate the molecular mechanism responsible for Rac mediated angiogenesis in HCC metastasis and eventually facilitate the development of new therapeutic strategies against HCC metastasis and recurrence. There are three mains specific objectives of this study: 1. Determine the correlation between Rac activation and VEGF expression in HCC clinical samples 2. Determine the signaling pathways of Rac medicated VEGF upregulation in HCC 3. Determine the effect of Rac inactivation on angiogenesis of HCC

Project Title:	Enhancement of therapeutic efficacy of hypoxia and chemotherapy in hepatocellular carcinoma by blockade of vascular endothelial growth factor receptors
Investigator(s):	Poon RTP
Department:	Surgery
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	09/2005

Abstract:

N/A

Project Title:	Enhancement of therapeutic efficacy of hypoxia and chemotherapy in hepatocellular carcinoma by blockade of vascular endothelial growth factor receptors
Investigator(s):	Poon RTP, Yang Z
Department:	Surgery
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2005

Abstract:

To study whether antiangiogenic therapy using a tyrosine inhibitor of VEGF receptors, PTK 787, can enhance the efficacy of chemotherapy and tumor hypoxia treatment for hepatocellular carcinoma (HCC) in a rat orthotopic HCC model. GF

Project Title:	Training courses on radiofrequency ablation for liver cancers
Investigator(s):	Poon RTP, Fan ST, Lam CM, Ng KC, Tso WK, Yuen JHF, Tung HKS, Tsang JCW
Department:	Surgery
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	12/2005

Abstract:

To provide comprehensive training courses for doctors from Hong Kong, Macau and China on treatment of liver cancers using radiofrequency ablation (RFA) before they embark on this treatment in their respective hospitals.

List of Research Outputs

Chan F.S.Y., Ng K.K.C., Poon R.T.P., Yuen J.H.F. and Fan S.T., Comparison of radiofrequency ablation and hepatic re-resection for intrahepatic recurrent hepatocellular carcinoma (Abstract), The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2-3 December 2005.

Chong W.P., To Y.F., Ip W.K.E., Yuen R.M.F., Poon R.T.P., Wong W.H.S., Lai C.L. and Lau Y.L., Mannose-binding lectin in chronic hepatitis B virus infection, Hepatology. 2005, 42(5): 1037-1045.

Ho J.W.Y., Man K., Sun K.W., Lee K.W., Poon R.T.P. and Fan S.T., Effects of a novel immunomodulating agent, FTY720, on tumor growth and angiogenesis in hepatocellular carcinoma, Molecular Cancer Therapeutics. 2005, 4(9): 1430-1438.

Hui C.K., Lau E., Monto A., Kim M., Luk J.M.C., Poon R.T.P., Leung N., Lo C.M., Fan S.T. and Lau G., Natural history of patients with recurrent chronic hepatitis C virus and occult hepatitis B co-infection after liver transplanation, AM J Transplanation. 2006, 6(7): 1600-8.

Lam C.M., Yong J.L., Chan O.O., Ng K.K.C., Poon R.T.P., Liu C.L., Lo C.M. and Fan S.T., Better survival in female patients with hepatocellular carcinoma: oral contraceptive pills related?, Journal of Clinical Gastroenterology. 2005, 39(6): 533-539.

Lee K.W., Man K., Ho J.W.Y., Wang X., Poon R.T.P., Xu Y., Ng T.P., Chu A.C.Y., Sun K.W., Ng I.O.L., Sun H.C., Tang Z.Y., Xu R. and Fan S.T., FTY720: a promising agent for treatment of metastatic hepatocellular carcinoma, Clinical Cancer Research. 2005, 11(23): 8458-8466.

Lee K.W., Poon R.T.P., Tang Z.Y., Sun H.C. and Fan S.T., Identification of L1CAM as the potential biomarker for HCC metastasis (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A78.

Lee K.W., Poon R.T.P., Man K., Guan X.Y. and Fan S.T., Identification of biomarkers for metastatic hepatocellular carcinoma (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Lee K.W., Poon R.T.P. and Fan S.T., Rac activiation is associated with HCC metastasis through upregulation of VEGF in hepatocellular carcinoma (Abstract), The 97th Annual Meeting of the American Association of Cancer Research, Washington D.C., U.S.A., 1 - 5 April 2006.

Liem M.S.L., Poon R.T.P., Lo C.M., Tso W.K. and Fan S.T., Outcome of transarterial chemoembolization in patients with inoperable hepatocellular carcinoma eligible for radiofrequency ablation, World Journal of Gastroenterology. 2005, 11(29): 4465-4471.

Liu C.L., Fan S.T., Lo C.M., Tso W.K., Wong Y., Poon R.T.P., Lam C.M., Wong B.C.Y. and Wong J., Clinicobiochemical prediction of biliary cause of acute pancreatitis in the era of endoscopic ultrasonography, Alimentary Pharmacology and Therapeutics. 2005, 22(5): 423-431.

Liu C.L., Fan S.T., Lo C.M., Tso W.K., Wong Y., Poon R.T.P., Lam C.M., Wong B.C.Y. and Wong J., Comparison of early endoscopic ultrasonography and endoscopic retrograde cholangiopancreatography in the management of acute biliary pancreatitis: a prospective randomized study, Clinical Gastroenterology and Hepatology. 2005, 3(12): 1238-1244.

Liu Y., Poon R.T.P., Qian X.M., Li L., Lau C.P.Y., Chen Y.J., Kok T.W. and Fan S.T., A study of the effect of vascular endothelial growth factor tyrosine kinase inhibitor PTK 787/ZK222584 on liver fibrosis (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Liu Y., Poon R.T.P., Li L., Qian X., Chen Y.J., Yang X., Sun H.C., Tang Z.Y. and Fan S.T., Synergistic inhibitory effects of PTK787/ZK222584 and interferon-alfa on hepatocellular carcinoma with metastatic potential (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25 - 28 March 2006.

Liu Y., Poon R.T.P., Li L., Qian X., Chen Y., Xu Y., Sun H.C., Tang Z.Y. and Fan S.T., Synergistic inhibitory effects of PTK787/ZK222584 and interferon-alfa on hepatocellular carcinoma with metastatic potential (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A94.

Lum C.T., Yang Z., Li H.Y., Sun R.W.Y., Fan S.T., Poon R.T.P., Lin M.C., Che C.M. and Kung H., Gold(III) compound is a novel chemocytotoxic agent for hepatocellular carcinoma, International Journal of Cancer. 2006, 118(6): 1527-1538.

Man K., Sun K.W., Liu C.L., Ng T.P., Ho J.W.Y., Poon R.T.P. and Fan S.T., The significance of cell adhesion kinase in recurrence of hepatocellular carcinoma after curative liver resection (Abstract), The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2-3 December 2005.

Ng K.K.C., Poon R.T.P., Chan F.S.Y., Yuen J.H.F., Tso W.K. and Fan S.T., Comparison of radiofrequency ablation and hepatic re-resection for intrahepatic recurrent hepatocellular carcinoma (Oral Presentation), The 106th Annual Congress of Japan Surgical Society, Tokyo, Japan, 29-31 March 2006.

Ng K.K.C., Poon R.T.P., Lam C.M., Yuen J.H.F., Tso W.K. and Fan S.T., Efficacy and safety of radiofrequency ablation for perivascular hepatocellular carcinoma without hepatic inflow occlusion, British Journal of Surgery. 2006, 93(4): 440-447.

Ng K.K.C. and Poon R.T.P., Radiofrequency ablation for malignant liver tumor, Surgical Oncology. 2005, 14(1): 41-52.

Ng K.K.C., Poon R.T.P., Lo C.M., Yuen J.H.F., Tso W.K. and Fan S.T., Recurrence pattern and survival outcome after radiofrequency ablation of hepatocellular carcinoma (Abstract), The 16th World Congress of the International Association of Surgeons and Gastroenterologists, Madrid, Spain, 25 - 27 May 2006.

Ng K.K.C., Lam C.M., Poon R.T.P., Shek T.W.H., Ho D.W.Y. and Fan S.T., Safety limit of large-volume hepatic radiofrequency ablation in a rat model, Archives of Surgery. 2006, 141(3): 252-258.

Ng K.K.C., Poon R.T.P., Lo C.M., Liu C.L. and Fan S.T., Survival analysis of patients with transplantable hepatocellular carcinoma: an implication for salvage transplantation (Abstract), The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2-3 December 2005.

Ng K.K.C., Poon R.T.P., Lo C.M., Liu C.L., Lam C.M. and Fan S.T., Survival analysis of patients with transplantable recurrent hepatocellular carcinoma: an implication for salvage liver transplantation (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Pang R.W.C., Poon R.T.P., Lee K.W., Fan S.T., Kwong Y.L. and Tse E.W.C., PIN1 interacts with a specific serine-proline motif of hepatitis B virus X protein to enhance hepatocarcinogenesis (Abstract), The 97th Annual Meeting of the American Association of Cancer Research, Washington D.C., U.S.A., 1 - 5 April 2006.

Pawlik T.M., Delman K.A., Vauthey J.N., Nagorney D.M., Ng I.O.L., Ikai I., Yamaoka Y., Belghiti J., Lauwers G.Y., Poon R.T.P. and Abdalla E.K., Tumor size predicts vascular invasion and histologic grade: Implications for selection of surgical treatment for hepatocellular carcinoma, Liver Transplantation. 2005, 11(9): 1086-92.

Poon R.T.P., Antiangiogenic therapy for hepatocellular carcinoma (Invited Lecture), Postgraduate Course, Shanghai-Hong Kong International Liver Congress, Shanghai, China, 25-28 March 2006. 2006.

Poon R.T.P., Associate Director (March 2005 - present), Continuous Medical Education Office, Hong Kong Academy of Medicine . 2006.

Poon R.T.P., Associate Editor (July 2003 - present), Cancer Reviews: Asia-Pacific. 2006.

Poon R.T.P., Chairman - Basic Research Symposium, Hong Kong Surgical Forum, Hong Kong, 13 January 2006. 2006.

Poon R.T.P., Chairman - Free Paper Session "Gastric and Esophageal Adenocarcinoma", The 16th World Congress of the International Association of Surgeons and Gastroenterologists, Madrid, Spain, 25 - 27 May 2006. 2006.

Poon R.T.P., Chairman - Free Paper Session "Hepatocellular Carcinoma", The 16th World Congress of the International Association of Surgeons and Gastroenterologists, Madrid, Spain, 25 - 27 May 2006. 2006.

Poon R.T.P., Chairman - State-of-the-Art Lecture "Extracorporeal high intensity ultrasound: a novel cancer treatment" by Prof. Feng Wu, The 12th Hong Kong International Cancer Congress and The 2nd Annual Scientific Meeting of Centre of Cancer Research, The University of Hong Kong, Hong Kong, 8-10 December 2005. 2005.

Poon R.T.P., Chairman - State-of-the-Art Lecture "Molecular imagings of cancer" by Dr. Edward Wu, The 12th Hong Kong International Cancer Congress and The 2nd Annual Scientific Meeting of Centre of Cancer Research, The University of Hong Kong, Hong Kong, 8-10 December 2005. 2005.

Poon R.T.P., Chairman - Symposium "Cholangiocarcinoma", International Surgical Week 2005 and The 4th World Congress of Surgery, Durban, South Africa, 21-25 August 2005. 2005.

Poon R.T.P., Chairman - Symposium "Clinical Practice Exchanges and Problems in Hepatic Nutrition Support", The 1st Meeting of Clinical Nutrition in Liver Diseases, Tokushima, Japan, 18 May 2006. 2006.

Poon R.T.P., Chairman - Symposium "New Paradigm on Cholangiocarcinoma", The 15th Conference of Asian Pacific Association for the Study of the Liver, Bali, Indonesia, 18-21 August 2005. 2005.

Poon R.T.P., Co-chairman of Organizing Committee and Scientific Committee, The 1st World Conference of Interventional Oncology, Lake Como, Italy, 12 - 16 June 2006. 2006.

Poon R.T.P., Colorectal liver metastasis: is tumor ablation an alternative to surgery or chemotherapy? (Main Session Lecture), International Surgical Week 2005 and The 4th World Congress of Surgery, Durban, South Africa, 21-25 August 2005. 2005.

Poon R.T.P., Committee Member (March 2004 - present), Chinese Chapter of International Hepato-Pancreato-Biliary Association. 2006.

Poon R.T.P., Committee Member of Research Support for Higher Surgical Trainees Committee (2003 - present), The College of Surgeons of Hong Kong. 2006.

Poon R.T.P., Current results of radiofrequency ablation for hepatocellular carcinoma (Invited Lecture), Radiofrequency Ablation Course, Department of Surgery and Department of Radiology, Queen Mary Hospital and Hong Kong Society of Interventional Radiology, Hong Kong, 17-18 March 2006. 2006.

Poon R.T.P., Deputy Chairman (2003 - present), Institutional Review Board of West Cluster Hospitals and The University of Hong Kong. 2006.

Poon R.T.P., Director of Postgraduate Course on Hepatocellular Carcinoma, Shanghai-Hong Kong International Liver Congress, Shanghai, China, 25 March 2006. 2006.

Poon R.T.P., Editor (August 2005 - present), Cutting Edge (College Newsletter), The College of Surgeons of Hong Kong. 2005.

Poon R.T.P., Editor (August 2005 - present), Journal of Pancreas. 2005.

Poon R.T.P., Epidemiology of hepatocellular carcinoma: comparison of East and West data (Invited Lecture), The 15th Conference of Asian Pacific Association for the Study of the Liver, Bali, Indonesia, 18-21 August 2005. 2005.

Poon R.T.P., Guest Editor, Theme Symposium on "Role of Minimally Invasive Surgery for Hepatobiliary Malignancies", Surgical Practice. 2005, 9.

Poon R.T.P., Hepatobiliary-pancreatic surgery (Invited Lecture), Post-graduate Certificate Course in Peri-operative Nursing, Hospital Authority, Hong Kong, 25 February 2006. 2006.

Poon R.T.P., Hepatocellular carcinoma: resection and preoperative interventions including portal vein embolization (Invited Lecture) , Liver Oncology Research Consensus Panel, Society of Interventional Radiology, Toronto, Canada, 30 March 2006. 2006.

Poon R.T.P., Honorary Advisor for Continuing Medical Education Programme (December 1999 - present), The Association of Licentiates of Medical Council of Hong Kong. 2006.

Poon R.T.P., Honorary Consultant, Hong Kong Sanatorium and Hospital, Hong Kong. 2006.

Poon R.T.P., Honorary Consultant, Queen Mary Hospital, Hospital Authority, Hong Kong. 2006.

Poon R.T.P., Honorary Consultant, Tung Wah Hospital, Hospital Authority, Hong Kong. 2006.

Poon R.T.P., Honorary Fellow, National Chapter of European Hepatobiliary-Pancreatic Association, Republic of Serbia and Montenegro. 2006.

Poon R.T.P., Lee K.W., Yuen P.W., Ling M.T., Wang X., Wong Y.C., Guan X.Y., Man K. and Fan S.T., Id-1 promotes angiogenesis in hepatocellular carcinoma through HIF-1a-mediated VEGF upregulation (Abstract), The 97th Annual Meeting of the American Association of Cancer Research, Washington D.C., U.S.A., 1 - 5 April 2006.

Poon R.T.P., Impact of radiofrequency ablation for liver cancer (Invited Lecture), The 12th Hong Kong International Cancer Congress, Hong Kong, 9-10 December 2005. 2005.

Poon R.T.P., Instructor of Advanced Trauma Life Support Course (1998 - present), American College of Surgeons. 2006.

Poon R.T.P., International Guest Scholarship 2006, American College of Surgeons. 2005.

Poon R.T.P., Introduction to clinical research (Invited Lecture), Research Paper Writing Workshop for Higher Surgical Trainees, Hosptial Authority/Queen Mary Hospital, Hong Kong, 10 February 2006. 2006.

Poon R.T.P., Laparoscopic liver resection (Invited Lecture), Advanced Laparoscopic Course, Department of Surgery, Queen Mary Hospital, Hong Kong, 27 April 2006. 2006.

Poon R.T.P., Liver resection for hepatocellular carcinoma: indications and techniques (Invited Lecture), Postgraduate Course, Shanghai-Hong Kong International Liver Congress, Shanghai, China, 25-28 March 2006. 2006.

Poon R.T.P., Member (Representative of Hong Kong West Cluster) of Selection Board for Resident Specialist in Surgery, Hospital Authority, 7 December 2005. 2005.

Poon R.T.P., Member of Editorial Board (March 2003 - present), Cancer Therapy. 2006.

Poon R.T.P., Member of Editorial Board (November 2002 - present), 消化外科, 2006.

Poon R.T.P., Member of Liver Oncology Research Panel, The Society of Interventional Radiology, U.S.A.. 2006.

Poon R.T.P., Member of Organizing Committee, Shanghai-Hong Kong International Liver Congress, Shanghai, China, 25 - 28 March 2006. 2006.

Poon R.T.P., Member of Research Committee (2005 - present), The College of Surgeons of Hong Kong. 2006.

Poon R.T.P., Non-surgical treatment of hepatocellular carcinoma (State-of-the-Art Lecture), The 7th Annual Scientific Meeting, The Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006. 2006.

Poon R.T.P., Novel therapies for hepatocellular carcinoma (Invited Lecture), The 15th Conference of Asian Pacific Association for the Study of the Liver, Bali, Indonesia, 18-21 August 2005. 2005.

Poon R.T.P., Open, percutaneous, laparoscopic or transthoracic approach of radiofrequency ablation for hepatocellular carcinoma (Keynote Lecture), The 1st World Conference of Interventional Oncology, Lake Komo, Italy, 12 - 14 June 2006. 2006.

Poon R.T.P., Pancreatic leakage after pancreatcioduodenectomy (Invited Lecture), 16th World Congress of the International Association of Surgeons and Gastroenterologists, Madrid, Spain, 25-27 May 2006. 2006.

Poon R.T.P., Permanent Committee Member (2004 - present), International Hepatocellular Carcinoma Meeting, Hong Kong. 2006.

Poon R.T.P., Prevention and management of pancreatic leakage after pancreaticoduodenectomy (Invited Lecture), Hong Kong Surgical Forum, Hong Kong, 13-14 January 2006. 2006.

Poon R.T.P., Prevention and management of pancreatic leakage after pancreaticoduodenectomy (Invited Lecture), The 3rd Joint Beijing-Hong Kong Surgical Convention, Beijing, China, 16 January 2006. 2006.

Poon R.T.P., Radiofrequency ablation of hepatocellular carcinoma (Invited Lecture), The 11th Hong Kong Medical Forum, Department of Medicine, The University of Hong Kong, Hong Kong, 4 June 2006. 2006.

Poon R.T.P., Resection, transplantation or transarterial chemoembolization for hepatocellular carcinoma. Surgeon's point of view (Invited Lecture), The 16th World Congress of the International Association of Surgeons and Gastroenterologists, Madrid, Spain, 25 - 27 May 2006. 2006.

Poon R.T.P., Reviewer, American Journal of Gastroenterology. 2006.

Poon R.T.P., Reviewer, American Journal of Surgery. 2006.

Poon R.T.P., Reviewer, Annals of Surgery. 2006.

Poon R.T.P., Reviewer, Asian Journal of Surgery. 2006.

Poon R.T.P., Reviewer, British Journal of Surgery. 2006.

Poon R.T.P., Reviewer, Cancer. 2006.

Poon R.T.P., Reviewer, Cancer Letters. 2006.

Poon R.T.P., Reviewer, European Journal of Surgery. 2006.

Poon R.T.P., Reviewer, Gene Therapy. 2006.

Poon R.T.P., Reviewer, HBP Surgery. 2006.

Poon R.T.P., Reviewer, Hepatology. 2006.

Poon R.T.P., Reviewer, International Journal of Cancer. 2006.

Poon R.T.P., Reviewer, Journal of American College of Surgeons. 2006.

Poon R.T.P., Reviewer, Journal of Biomedical Science. 2006.

Poon R.T.P., Reviewer, Journal of Clinical Oncology. 2006.

Poon R.T.P., Reviewer, Journal of Gastroenterology and Hepatology. 2006.

Poon R.T.P., Reviewer, Journal of Hepatology. 2006.

Poon R.T.P., Reviewer, Journal of National Cancer Institute. 2006.

Poon R.T.P., Reviewer, Lancet. 2006.

Poon R.T.P., Reviewer, Liver International. 2006.

Poon R.T.P., Reviewer, Liver Transplantation. 2006.

Poon R.T.P., Reviewer, Medical Science Monitor. 2006.

Poon R.T.P., Role of brain-derived neurotrophic factor in hepatocellular carcinoma (Invited Lecture), Seoul International Symposium on Hepatitis and Hepatocellular Carcinoma, Seoul, Korea, 14 April 2006. 2006.

Poon R.T.P., Supplementation of branched chain amino acids in hepatocellular carcinoma (Keynote Lecture), The 1st Meeting of Clinical Nutrition in Liver Diseases, Tokushima, Japan, 18 May 2006. 2006.

Poon R.T.P., Surgical treatment of hepatocellular carcinoma (Keynote Lecture), Annual Scientific Meeting of the Korean Study Group on Liver Cancer, Seoul, Korea, 24 June 2006. 2006.

Poon R.T.P., Survival analysis after surgical treatment of hepatocellular carcinoma (Keynote Lecture), Shanghai-Hong Kong International Liver Congress, Shanghai, China, 25-28 March 2006. 2006.

Poon R.T.P., Techniques of radiofrequency ablation (Invited Lecture), Meet-the-Expert Session, The 1st World Congress of Interventional Oncology, Lake Komo, Italy, 12 - 14 June 2006. 2006.

Poon R.T.P., The role of minimally invasive surgery for liver malignancies (Editorial), Surgical Practice. 2005, 9(3): 75-77.

Poon R.T.P., Trends in therapy for hepatocellular carcinoma (Keynote Lecture), 2005 Pan Asia Pacific Oncology Summit, Chiba, Japan, 9-10 July 2005. 2005.

Poon R.T.P., Tutor and Mock Examiner, Preparatory Course for FRCS Examination, The College of Surgeons of Hong Kong, 2 September 2005. 2005.

Tam P.K.H., Poon R.T.P., Yang Z. and Fan S.T., mTOR inhibitor enhances chemosensitivity of hepatocellular carcinoma (Abstract), The 97th Annual Meeting of the American Association of Cancer Research, Washington D.C., U.S.A., 1 - 5 April 2006.

Tang C.M., Poon R.T.P. and Fan S.T., The significance of cyclooxygenase-2 expression in human hepatocellular carcinoma (Review Article), Biomedicine and Pharmacotherapy. 2005, 59(Suppl 2): S311-S316.

Yang Z., Ho D.W.Y., Lau C.K., Lam C.T., Lum C.T., Poon R.T.P. and Fan S.T., Allograft inflammatory factor-1 (AIF-1) is crucial for the survival and pro-inflammatory activity of macrophages, International Immunology. 2005, 17(11): 1391-1397.

Yang Z., Liu Y., Ho D.W.Y., Lau C.K., Poon R.T.P. and Fan S.T., Blockade of vascular endothelial growth factor (VEGF) receptor enhances the therapeutic efficacy of hypoxia and chemotherapy in hepatocellular carcinoma (Poster Presentation), The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2 - 3 December 2005.

Yang Z., Lau C.K., Ngai P.P., Ho D.W.Y., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Delayed immunosuppression induces long-term liver allograft survival through interleukin-10 (IL-10) dependent manner (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Yang Z., Poon R.T.P. and Fan S.T., Interplay between BDNF and platelet in hepatocellular carcinoma (Poster Presentation), The 97th Annual Meeting of the American Association of Cancer Research, Washington D.C., U.S.A., 1 - 5 April 2006.

Yang Z., Lau C.K., Ngai P.P., Ho D.W.Y., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Short-term cardiotrophin-1 (CT-1) rescues marginal cirrhotic liver remnant after major hepatectomy without increasing the risk of tumor recurrence (Oral Presentation), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A92.

Yang Z., Ngai P.P., Lau C.K., Tam K.H., Ho D.W.Y., To J.Y.T., Poon R.T.P. and Fan S.T., Transient production of interleukin-10 (IL-10) by residual macrophages is crucial for the ischemia/reperfusion injury and long-term allograft survival in liver transplantation (Oral Presentation), The 8th International Congress of the Cell Transplant Society, Milan, Italy, 24 - 26 May 2006.

Researcher : Qian X

List of Research Outputs

Liu Y., Poon R.T.P., Li L., Qian X., Chen Y.J., Yang X., Sun H.C., Tang Z.Y. and Fan S.T., Synergistic inhibitory effects of PTK787/ZK222584 and interferon-alfa on hepatocellular carcinoma with metastatic potential (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25 - 28 March 2006.

Liu Y., Poon R.T.P., Li L., Qian X., Chen Y., Xu Y., Sun H.C., Tang Z.Y. and Fan S.T., Synergistic inhibitory effects of PTK787/ZK222584 and interferon-alfa on hepatocellular carcinoma with metastatic potential (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A94.

Researcher : Ren Y

Project Title:	Proteomics computational analysis of Severe Acute Respiratory Syndrome
Investigator(s):	Ren Y, Tam PKH, Peiris JSM, He Q, Fan J.Q.
Department:	Surgery
Source(s) of Funding:	VCO SARS Research Fund
Start Date:	07/2003

Abstract:

To investigate by using proteomics approach, combining Western blotting and ELISA: (a) identification of specific pattern in serum for the diagnosis and prognosis, (b) detection of immune-relevant proteins in SARS, (c) detection of proteins in different stages of SARS patients, (d) proteome analysis of SCV (proteome maps), (e) detection of expression patterns in virus infected cells.

List of Research Outputs

Fan J.Q., Chen Y., Chan H.M., Tam P.K.H. and Ren Y., Removing intensity effects and identifying significant genes for Affymetrix arrays in macrophage migration inhibitory factor-suppressed neuroblastoma cells, Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2005, 102(49): 17751-17756.

Ren Y., Xie Y. and Tam P.K.H., Dendritic cell (DC) enhances VEGF clearance from neuroblastoma - a mechanism for DC-based immunotherapy., 97th Annual Meeting of American Association for Cancer Research, Washington, DC, U.S.A., 1-5 April 2006.

Ren Y., Cao B., Law S.Y.K., Xie Y., Lee P.Y., Cheung C.M., Chen Y., Huang X., Chan H.M., Zhao P., Luk J.M.C., Vande Woude G. and Wong J., Hepatocyte growth factor promotes cancer cell migration and angiogenic factors expression: a prognostic marker of human esophageal squamous cell carcinomas, Clinical Cancer Research. 2005, 11(17): 6190-6197.

Ren Y., Chan H.M., Fan J., Xie Y., Chen Y., Li W., Jiang G., Liu Q., Meinhardt A. and Tam P.K.H., Inhibition of tumor growth and metastasis in vitro and in vivo by targeting macrophage migration inhibitory factor in human neuroblastoma, Oncogene. 2006, 25(25): 3501-3508.

Ren Y., Law S.Y.K., Huang X., Lee P.Y., Bacher M., Srivastava G. and Wong J., Macrophage migration inhibitory factor stimulates angiogenic factor expression and correlates with differentiation and lymph node status in patients with esophageal squamous cell carcinoma, Annals of Surgery. 2005, 242(1): 55-63.

Xie Y., Ren Y. and Tam P.K.H., Dendritic cells (DC) enhance VEGF clearance from neuroblastoma - a mechanism for DC-based immunotherapy, 52nd Annual International Congress of British Association of Paediatric Surgeons, Dublin, Ireland, 12-15 July 2005.

Researcher : Singh N

List of Research Outputs

Singh N., Lo C.Y. and Chan W.F., Laparoscopic enucleation of a nonfunctioning neuroendocrine tumor at the head of the pancreas, Journal of the Laparoendoscopic Surgeons. 2006, 10(2): 259-262.

Researcher : Siu YT

List of Research Outputs

Tsui T.Y., Siu Y.T., Ho D.W.Y., Ma J., Lau C.K., Schlitt H.J. and Fan S.T., Heme oxygenase-1-derived carbon monoxide stimulates adenosine triphosphate generation in human hepatocyte, Biochemical and Biophysical Research Communications. 2005, 336(3): 898-902.

Researcher : So MT

List of Research Outputs

Lau K.C., Garcia-Barcelo M.M., Leon Y.Y., So M.T., Miao X., Ngan E.S.W., Lui V.C.H., Cass D.T., Croaker G.D.H. and Tam P.K.H., Evaluation of thyroid transcription factor 1 (TTF-1) as a Hirschsprung's disease (HSCR) locus by mutation analysis, 39th Annual Meeting of the Pacific Association of Pediatric Surgeons, Taipei, Taiwan, 14-18 May 2006.

Lau K.C., Garcia-Barcelo M.M., Leon Y.Y., So M.T. and Tam P.K.H., Evaluation of thyroid transcription factor 1 (TTF-1) as a Hirschsprung's disease (HSCR) locus by mutation analysis, Development of the Enteric Nervous System: Cells, signals and genes, New York, U.S.A., 26-29 March 2006.

Researcher : Su M

List of Research Outputs

Man K., Su M., Ng T.P., Lo C.M. and Fan S.T., Rapamycin attenuates liver graft injury in a cirrhotic rat liver transplantation model - the significance of down-regulation of Rho-ROCK pathway (Abstract), The 11th Congress of the International Liver Transplantation Society, Los Angeles, U.S.A., 20 - 23 July 2005.

Man K., Su M., Ng T.P., Lo C.M., Zhao Y., Ho J.W.Y., Sun K.W., Lee K.W. and Fan S.T., Rapamycin attenuates liver graft injury in cirrhotic recipient - the significance of down-regulation of Rho-ROCK-VEGF pathway, American Journal of Transplantation. 2006, 6(4): 697-704.

Man K., Lo C.M., Ng T.P., Xiao J., Sun K.W., Su M. and Fan S.T., Significant activation of cell invasion, migration and angiogenesis pathways in small-for-size grafts may potentially increase tumour recurrence after living donor liver transplantation (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Researcher : Su YCF

Project Title:	*A reassessment of the taxonomic relationships of Petalolophus* and Pseuduvaria (Annonaceae)**
Investigator(s):	Su YCF, Saunders RMK
Department:	Ecology & Biodiversity
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004
Completion Date:	04/2006

Abstract:

To reassess the taxonomic status of Petalolophus and Pseuduvaria, which are believed to be phylogentically close.

List of Research Outputs

Researcher : Sun KW

List of Research Outputs

Ho J.W.Y., Man K., Sun K.W., Lee K.W., Poon R.T.P. and Fan S.T., Effects of a novel immunomodulating agent, FTY720, on tumor growth and angiogenesis in hepatocellular carcinoma, Molecular Cancer Therapeutics. 2005, 4(9): 1430-1438.

Lee K.W., Man K., Ho J.W.Y., Wang X., Poon R.T.P., Xu Y., Ng T.P., Chu A.C.Y., Sun K.W., Ng I.O.L., Sun H.C., Tang Z.Y., Xu R. and Fan S.T., FTY720: a promising agent for treatment of metastatic hepatocellular carcinoma, Clinical Cancer Research. 2005, 11(23): 8458-8466.

Man K., Zhao Y., Xu A., Lo C.M., Lam K.S.L., Ng T.P., Ho J.W.Y., Sun K.W., Lee K.W., Li X. and Fan S.T., Fat-derived hormone adiponectin combined with FTY720 significantly improves small-for-size fatty liver graft survival, American Journal of Transplantation. 2006, 6(3): 467-476.

Man K., Su M., Ng T.P., Lo C.M., Zhao Y., Ho J.W.Y., Sun K.W., Lee K.W. and Fan S.T., Rapamycin attenuates liver graft injury in cirrhotic recipient - the significance of down-regulation of Rho-ROCK-VEGF pathway, American Journal of Transplantation. 2006, 6(4): 697-704.

Man K., Lo C.M., Ng T.P., Sun K.W. and Fan S.T., Significant activation of cell invasion, migration and angiogenesis pathways in small-for-size grafts may potentially increase tumor recurrence after living donor liver transplantation (Abstract), The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2-3 December 2005.

Man K., Lo C.M., Ng T.P., Xiao J., Sun K.W., Su M. and Fan S.T., Significant activation of cell invasion, migration and angiogenesis pathways in small-for-size grafts may potentially increase tumour recurrence after living donor liver transplantation (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Man K., Lo C.M., Ng T.P., Ng T.P., Sun K.W. and Fan S.T., Significant activation of cell invasion, migration and angiogensis pathways in small-for-size grafts may potential increase tumor recurrence after living donor liver transplantation (Abstract), The 11th Congress of the International Liver Transplantation Society, Los Angeles, U.S.A., 20 - 23 July 2005.

Man K., Lo C.M., Ng T.P., Sun K.W. and Fan S.T., The significance of acute phase graft injury on tumor recurrence and metastases in living donor liver transplantation (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A204.

Man K., Sun K.W., Liu C.L., Ng T.P., Ho J.W.Y., Poon R.T.P. and Fan S.T., The significance of cell adhesion kinase in recurrence of hepatocellular carcinoma after curative liver resection (Abstract), The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2-3 December 2005.

Man K., Lo C.M., Xiao J.W., Ng T.P., Ng I.O.L., Sun K.W., Cheng Q. and Fan S.T., The significance of graft size on tumor recurrence/metastases after liver transplantation – Activation of cell invasion and migration pathways (Abstract), The 2006 Joint International Congress of the International Liver Transplantation Society (ILTS), the European Liver and Intestinal Transplant Association (ELITA), and the Liver Intensive Care Group of Europe (LICAGE), Milan, Italy, 3 - 6 May 2006. Liver Transplantation. 2006, 12: C30.

Researcher : Sun YW

List of Research Outputs

Chan O.O., Chu K.M., Leung S.Y., Huang C., Sun Y.W., Ko S., Yuen R.M.F., Xia H.H.X., Cho C.H., Hui W.M., Lam S.K., Rashid A. and Wong B.C.Y., Helicobacter pylori infection, interleukin 1 beta polymorphism and predisposition to gastric cancer through the CpG island methylation pathway, Presented at 11th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong, 14 January 2006.

Chan O.O., Chu K.M., Sun Y.W., Cheung H.K.L., Lam S.K., Yuen R.M.F., Hui W.M. and Wong B.C.Y., The association between interleukin 1 beta polymorphism and hypermethylation at tumor suppressor genes in gastric cancer. , Gastroenterology. 2005, 128 (Suppl 2): 1399-400.

Researcher : Tam KH

List of Research Outputs

Yang Z., Lau C.K., Ngai P.P., Ho D.W.Y., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Delayed immunosuppression induces long-term liver allograft survival through interleukin-10 (IL-10) dependent manner (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Yang Z., Lau C.K., Ngai P.P., Ho D.W.Y., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Short-term cardiotrophin-1 (CT-1) rescues marginal cirrhotic liver remnant after major hepatectomy without increasing the risk of tumor recurrence (Oral Presentation), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A92.

Yang Z., Ngai P.P., Lau C.K., Tam K.H., Ho D.W.Y., To J.Y.T., Poon R.T.P. and Fan S.T., Transient production of interleukin-10 (IL-10) by residual macrophages is crucial for the ischemia/reperfusion injury and long-term allograft survival in liver transplantation (Oral Presentation), The 8th International Congress of the Cell Transplant Society, Milan, Italy, 24 - 26 May 2006.

Researcher : Tam PC

List of Research Outputs

Chu T.Y., Tam P.C., Wong C.W., Wong B., Cheung M.C., Chu S.S.M. and Leung S.Y.L., Significance of testicular microlithiasis on ultrasonography findings of symptomatic men (Abstract), Surgical Practice. 2006, 10 (Suppl.): S9.

Lee N.P., Leung K.W., Wo J.Y., Tam P.C., Yeung W.S.B. and Luk J.M.C., Blockage of testicular connexins induced apoptosis in rat seminiferous epithelium, Apoptosis. 2006, 11(7): 1215-1229.

Lee P.Y., Tong M.K., Leung P.L., Chan V.W.M., Leung S.Y.L., Tam P.C., Chan K.W., Lee C.K.F., Yeung W.S.B. and Luk J.M.C., Kidney claudin-19: Localization in distal tubules and collecting ducts and dysregulation in polycystic renal disease, FEBS Letters. 2006, 580(3): 923-31.

Leung S.Y.L., Wong B.B.W., Cheung M.C., Ho K.L., Lee F.C.W. and Tam P.C., Intrarectal administration of Iidocaine gel versus plain lubricant gel for pain control during transrectal ultrasound-guided extensive 10-core prostate biopsy in Hong Kong Chinese population: prospective double-blind randomized controlled trial, Hong Kong Medical Journal. 2006, 12(2): 103-107.

Tam P.C., A large-scale nocturia survey in Hong Kong, Joint Urology Symposium of The Royal College of Surgeons of Edinburgh and The College of Surgeons of Hong Kong, Hong Kong, 22 October 2005.

Tam P.C., Chairman, Urology Board, The College of Surgeons of Hong Kong. 2006.

Tam P.C., Common Urological Problems, In: Chan TM, Chan MK, Integrated Systematic Nephrology. Hong Kong, Hong Kong University Press, 2006, Chapter 19, Third Edition: 119-123.

Tam P.C., Council Member (2004 - present), Asia Pacific Society of Sexual Medicine. 2006.

Tam P.C., Council Member (2005 - present), The College of Surgeons of Hong Kong. 2006.

Tam P.C., Deputy Secretary General (1996 - present), Asian Surgical Association. 2006.

Tam P.C., Examiner in Conjoint Urology Fellowship Examination, College of Surgeons of Hong Kong & Royal College of Surgeons of Edinburgh. 2006.

Tam P.C., Honorary Consultant (1996 - present), Sexual Rehabilitation Service ReHaAid. 2006.

Tam P.C., Honorary Consultant (Urology) (1998 - present), Tung Wah Hospital. 2006.

Tam P.C., Member (1990 - present), Central Renal Committee, Hospital Authority (Formerly Hospital Service Department). 2006.

Tam P.C., Member (2000 - present), Working Group on Male Sexual and Reproductive Health, The Family Planning Association of Hong Kong. 2006.

Tam P.C., Member of Editorial Board (2005 - present), Hong Kong Medical Journal. 2006.

Tam P.C., Optimizing the management of erectile dysfunction, CME Program for Physicians at Baptist Hospital, Hong Kong Baptist Hospital, Hong Kong, 4 July 2005.

Tam P.C., Radical cystectomy; refining the techniques (Invited), 15th Asian Congress of Surgery, the Royal College of Surgeons of Thailand and the Asian Surgical Association, Thailand, 20-23 July 2005.

Tam P.C., Radical retropubic prostatectomy - antegrade approach, Symposium on Prostate Carcinoma, The College of Hong Kong, Hong Kong, 28 November 2005.

Tam P.C. and Ho K.L., The overactive bladder - current concepts and pharmacology, In: Wong MYC, Approach to female Urology - Reflecting Asian Views. Singapore, Asian Society for Female Urology, 2005, 50-54.

Tam P.C., Vice-Chairman (2003 - present), Specialty Group in Urology Service, Hospital Authority. 2006.

Tam P.C., Visiting Urologist (1992 - present), MacLehose Medical Rehabilitatio Centre. 2006.

Tso W.K., Wong S., Tsang J., Tung H., Tai K.S., Tam P.C. and Leong L., Embolotherapy with a mixture of lipiodol and ethanol for renal angiomyolipoma: retrospective study, Journal of Hong Kong College of Radiologists. 2005, 8: 78-82.

Wong C.W. and Tam P.C., Serum FSH level and testicular volume as predictive factors for successful sperm recovery in nonobstructive azoospermic patients (Abstract), Surgical Practice. 2006, 10 (Suppl.): S15.

Researcher : Tam PKH

Project Title:	Transgenesis animals as bioreactors: production of a new immunosuppressive protein CTLA4Ig by transgenesis
Investigator(s):	Tam PKH, Wong NS, Cheah KSE, Dallman M.J., Sun F.Z.
Department:	Surgery
Source(s) of Funding:	Vice-Chancellor's Office - General Award
Start Date:	07/1997

Abstract:

The use of transgenic farm animals as bioreactors is a potentially powerful and important new industry for the next century. This application of transgenic technology, in combination with the recent advance in ability to clone animals from adult cells, enhances the potential of transgenic animal bioreactors as major producers of therapeutic proteins. Therefore by initiating research in this area there are immediate and long-term benefits to Hong Kong and China.

Project Title:	Establishing a "train-the-trainers" programme for paediatric surgery in China
Investigator(s):	Tam PKH, Lin CL
Department:	Surgery
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	10/1998

Abstract:

To improve the standard of surgical care of children in China through the establishment of a scheme of "train-the-trainers"; to improve our understanding of special paediatric surgical issues relevant to the Chinese population (e.g. disease patterns, transferability of western "advances" to China etc.) through systematic exchanges with major centres in China and hence enhance our ability to deliver better surgical care to children in Hong Kong.

Project Title:	Expanding the "Train-the-Trainers" programme for paediatric surgery in China
Investigator(s):	Tam PKH, Lin CL, Zhang J.Z., Wang W.L., Shi C.R.
Department:	Surgery
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	10/2000

Abstract:

To improve the standard of surgical care of children in China through the consolidation and expansion of a scheme of "Train-the-Trainers"; to improve our understanding of special paediatric surgical issues relevant to the Chinese population (e.g. disease patterns, transferability of western "advances" to China etc) through systematic exchanges with major centres in China and hence enhance our ability to deliver better surgical care to children in Hong Kong; to promote modern concepts of medical education among leaders of the new generation of doctors through the introduction of structured training, problem-based learning, life-long learning, and the use of evidence-based medicine and information technology.

Project Title:	Sonic hedgehog signalling in chronic allograft rejection
Investigator(s):	Tam PKH, Tian L, Dallman M.J., Lamb J.R.
Department:	Surgery
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2002
Completion Date:	08/2005

Abstract:

To investigates the role of Notch, Sonic hedgehog (Shh) signalling in acute and chronic graft rejection in a rat model of small bowel transplantation; to study if the blockade of Shh signalling alone or in conjunction with the use of TFG-[beta] inhibitors can ameliorate chronic rejection.

Project Title:	The role of sonic hedgehog in immune system
Investigator(s):	Tam PKH, Tian L, Chan VSF, Lamb J.R.
Department:	Surgery
Source(s) of Funding:	Other Funding Scheme
Start Date:	10/2002

Abstract:

To elucidate the role of sonic hedgehog in CD4^{+ T cells activation and to identify its downstream targets suring
T cell activation.}

Project Title:	Improving the survival and quality of life of children with cancers in China
Investigator(s):	Tam PKH, Wong IHN, Chan GCF, Ren Y, Lin CL, Li Z.Z., Zhang J.Z., Wang W.L., Shi C.R.
Department:	Surgery
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	10/2003

Abstract:

To improve the survival and quality of life of poor and sick children suffering from cancer through the establishment of a Chinese Children Cancer Consortium which will be responsible for the introduction and implementation of modern, comprehensive management protocols, and for training and educating health care workers around the country to adopt the new standard of cares for children with cancer.

Project Title:	The study of co-stimulatory function of sonic hedgehog in CD⁴⁺ lymphocytes
Investigator(s):	Tam PKH, Chan VSF, Lamb J.R.
Department:	Surgery
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Abstract:

To study the distribution of Shh and its receptors on the surface of T cells during T cell activation; to study the effect of Shh on TH1 and TH2 cell differentiation; to identify the downstream targets of Shh signaling pathway in CD⁴⁺ T lymphocytes.

Project Title:	*Evaluation of HOXB5* as a new Hirschprung's disease susceptibility locus**
Investigator(s):	Tam PKH, Lui VCH, Garcia-Barcelo MM
Department:	Surgery
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Abstract:

To evaluate the human HOXB5 gene as a new Hirschsprung's disease susceptibility locus.

Project Title:	Further expansion of the "Train-the-Trainers" programme for paediatric surgery in China
Investigator(s):	Tam PKH, Wong KKY, Chan KL, Yip KF, Wang W.L., Shi C.R., Zhang J.Z., Zhan JH, Jin XQ
Department:	Surgery
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	05/2005

Abstract:

The project aims to improve the standard of surgical care of children in China; to improve understanding of special paediatric surgical issues relevant to the Chinese population; and to promote modern concepts of medical education among leaders of the new generation of doctors in China.

Project Title:	University strategic research theme: Genomics, Proteomics & Bioinformatics
Investigator(s):	Tam PKH, Leung FCC, Chen SF, Che CM, He Q, Ng KP
Department:	Surgery
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	05/2005

Abstract:

To facilitate multidisciplinary research in the areas of genomics, proteomics and bioinformatics. The three subthemes would be created, and an additional subtheme on thical, legal and social issues (ELSI) should be created.

List of Research Outputs

Burzynski G., Amiel J., Antinolo G., Borrego, S., Ceccherini I., Emison E., Eng C., Fernandez R., Garcia-Barcelo M.M., Griseri P., Hofstra R., Kashuk C., Lantieri F., Lyonnet S., Tam P.K.H., Tullio-Pelet A. and West K., Chakravarti A., Differential liabilities of coding and non-coding mutations in complex disease , Annual Meeting of the American Society of Human Genetics. Salt Lake City, USA, October 25-29 2005.. 2005.

Cai Q., Tian L., Chen Y., Chan V.S.F., Thompson P.W., Lamb J.R. and Tam P.K.H., The effect of PPAR-gamma agonist in HUVEC activation, 30th FEBS Congress & 9th IUBMB Conference, Budapest, Hungary, 2-7 July 2005.

Chan K.L., Tang M.H.Y., Tse H.Y., Tang R.Y.K. and Tam P.K.H., Meconium peritonitis: prenatal diagnosis, postnatal management and outcome, Prenatal Diagnosis. 2005, 25: 676-682.

Chan K.L., Hui W.C. and Tam P.K.H., Prospective, randomized, single-center, single-blind comparison of laparoscopic vs open repair of pediatric inguinal hernia, Surgical Endoscopy. 2005, 19: 927-932.

Chan V.S.F., Chan Y.K., Chen Y., Poon L.L.M., Cheung A.N.Y., Zheng B., Chan K.H., Mak W.W., Ngan H.Y.S., Xu X., Screaton G., Tam P.K.H., Austyn J.M., Chan L.C., Yip S.P., Peiris J.S.M., Khoo U.S. and Lin C.L., Homozygous L-SIGN (CLEC4M) plays a protective role in SARS coronavirus infection. , Nature Genetics. 2006, 38: 38-46.

Emison E., Burzynski G., Amiel J., Borrego S., Ceccherini, I., Fernandez R., Garcia-Barcelo M.M., Griseri P., Hofstra R., Kashuk C.S., Lantieri F., Lyonnet S., Tam P.K.H., Pecina A., Tullio-Pelet and A., West K., Chakravarti A., Differential liabilities of rare coding and common non-coding RET mutations explain the multifactorial genetics of Hirschsprung disease. , Gordon Research Conference on Human Genetics and Genomics Salve Regina University Newport, RI, USA, July 24-29, 2005.

Fan J.Q., Chen Y., Chan H.M., Tam P.K.H. and Ren Y., Removing intensity effects and identifying significant genes for Affymetrix arrays in macrophage migration inhibitory factor-suppressed neuroblastoma cells, Proceedings of the National Academy of Sciences of the United States of America (PNAS). 2005, 102(49): 17751-17756.

Garcia J.A. and Tam P.K.H., Promoter SNPs regulate RET transcription in Hirschsprung's disease, Human Molecular Genetics. 2006.

Garcia-Barcelo M.M., So M.T., Lau K.C., Leon Y.Y., Yuan Z., Cai W., Lui V.C.H., Fu M., Herbrick J.A., Gutter E., Proud V., Li L., Pierre-Louis J., Aleck K., van Heurn E., Belloni E., Scherer S.W. and Tam P.K.H., Population differences in the polyalanine domain and 6 new mutations in HLXB9 in patients with Currarino syndrome, Clinical Chemistry. 2006, 52(1): 46-52.

Khoo U.S., Chan V.S.F., Chan Y.K., Chen Y., Poon L.L.M., Cheung A.N.Y., Zheng B., Ngan H.Y.S., Tam P.K.H., Chan L.C., Yip S.P., Peiris J.S.M., Sham P.C. and Lin C.L., The protective role of homozygous L-SIGN (CLEC4M) in SARS coronavirus infection., HUGO's 11th Human Genome Meeting, Helsinki, Finland. . 2006.

Lan L.C.L., Yip P.K.F., Wong K.K.Y. and Tam P.K.H., Comparison of laparaoscopic vs open pyeloplasty in children, 39th Annual Meeting of the Pacific Association of Pediatric Surgeons, Taipei, Taiwan, 14-18 May 2006.

Lau K.C., Garcia-Barcelo M.M., Leon Y.Y., So M.T., Miao X., Ngan E.S.W., Lui V.C.H., Cass D.T., Croaker G.D.H. and Tam P.K.H., Evaluation of thyroid transcription factor 1 (TTF-1) as a Hirschsprung's disease (HSCR) locus by mutation analysis, 39th Annual Meeting of the Pacific Association of Pediatric Surgeons, Taipei, Taiwan, 14-18 May 2006.

Lau K.C., Garcia-Barcelo M.M., Leon Y.Y., So M.T. and Tam P.K.H., Evaluation of thyroid transcription factor 1 (TTF-1) as a Hirschsprung's disease (HSCR) locus by mutation analysis, Development of the Enteric Nervous System: Cells, signals and genes, New York, U.S.A., 26-29 March 2006.

Li X., Tian L., Lamb J.R. and Tam P.K.H., Anti-TGF-beta prevents chronic rejection in a rat orthotopic small bowel transplantation model, 52nd Annual International Congress of British Association of Paediatric Surgeons, Dublin, Ireland, 12-15 July 2005.

Lok C.N., Ho C.M., Chen R., He Q., Yu W.Y., Sun H., Tam P.K.H., Chiu J. and Che C.M., Proteomic analysis of the mode of antibacterial action of silver nanoparticles, 13th Symposium oc Chemistry Postgraduate Research In Hong Kong, Hong Kong, April 17, 2006.

Lok C.N., Ho C.M., Chen R., He Q., Yu W.Y., Sun H., Tam P.K.H., Chiu J. and Che C.M., Proteomic analysis of the mode of antibacterial action of silver nanoparticles, Journal of Proteome Research. 2006, 5: 916-924.

Lui V.C.H., Fu M., Poon H.C., Sham M.H., Pachnis V., Hui C.C. and Tam P.K.H., Conditional knockout of PTC1 gene in vagal neural crest cells causes defective ENS development in mice, Development of the Enteric Nervous System: Cells, signals and genes, New York, U.S.A., 26-29 March 2006. 2006.

Lui V.C.H., Cheng W.C., Chen Y., Sham M.H. and Tam P.K.H., Homeobox gene HOXB5 is required in the embryonic development of the enteric nervous system, 52nd Annual International Congress of British Association of Paediatric Surgeons, Dublin, Ireland, 12-15 July 2005.

Lui V.C.H., Leon Y.Y., Garcia-Barcelo M.M., Ganster R.W., Chen B.L.S., Hutson J.M. and Tam P.K.H., Novel RET mutation produces a truncated RET receptor lacking the intracellular signaling domain in a 3-generation family with Hirschsprung Disease, Clinical Chemistry. 2005, 51(8): 1552-1554.

Lui V.C.H., Cheng W.C., Chen Y., Sham M.H. and Tam P.K.H., Perturbation of Hoxb5 signalling in vagal neural crest cells causes defective development of the enteric nervous system, 15th International Society of Developmental Biologists Congress 2005, Sydney, Australia, 3-7 September 2005.

Ng K.M., Che C.M., Wo S.K., Tam P.K.H. and Lau A.S.Y., Analytical Application of Acetate Anion in Negative Electrospray Ionization Mass Spectrometry for the Analysis of Triterpenoid Saponins - Ginsenosides , Rapid Communications in Mass Spectrometry. John Wiley and Sons, 2006, 20: 1545 - 1550.

Ngan E.S.W., Lui V.C.H., Lau K.C., Garcia-Barcelo M.M. and Tam P.K.H., Transcriptional profiling of eneteric neural crest cells, Mechanisms of Development. 2005, 122: S179.

Ngan E.S.W., Lui V.C.H., Lau K.C., Garcia-Barcelo M.M., Sham M.H. and Tam P.K.H., Transcriptional profiling of enteric neural crest cells, 15th International Society of Developmental Biologists Congress 2005, Sydney, Australia, 3-7 September 2005.

Ren Y., Xie Y. and Tam P.K.H., Dendritic cell (DC) enhances VEGF clearance from neuroblastoma - a mechanism for DC-based immunotherapy., 97th Annual Meeting of American Association for Cancer Research, Washington, DC, U.S.A., 1-5 April 2006.

Ren Y., Chan H.M., Fan J., Xie Y., Chen Y., Li W., Jiang G., Liu Q., Meinhardt A. and Tam P.K.H., Inhibition of tumor growth and metastasis in vitro and in vivo by targeting macrophage migration inhibitory factor in human neuroblastoma, Oncogene. 2006, 25(25): 3501-3508.

Tam P.K.H., A boy who prefers to drink milk [Invited Lecture], 7th International Paediatric Surgical Week: Progress in Paediatric Surgery, Kuhtai, Austria, 11-18 March 2006. 2006.

Tam P.K.H., A mass here, a mass there, a mass somewhere [Invited Lecture], 7th International Paediatric Surgical Week: Progress in Paediatric Surgery, Kuhtai, Austria, 11-18 March 2006. 2006.

Tam P.K.H., Achalasia, In: Puri P, Hollwarth M (eds) Pediatric Surgery. Dublin, Ireland, Springer Surgery Atlas Series, 2006, Chapter 7: 61-66.

Tam P.K.H., Advances in Pediatric Surgery [Invited lecture], Inauguration Ceremony of Macau Pediatric Society, Macau, 20-21 May 2006. 2006.

Tam P.K.H., Advances in neuroblastoma research [Invited lecture], The 2nd National Congress on Surgery of Pediatric Oncology and the 1st Cross Strait Symposium of Pediatric Oncology, Chongqing, China, 20-22 October 2005. 2005.

Tam P.K.H., Development of Biotechnology and Genomics - perspectives from Hong Kong [Invited Lecture- PVC], APEC Biotechnology & BioBusiness Asia 2005 Conference, Taipei, Taiwan, 19 July 2005 . 2005.

Tam P.K.H., Developmental genetics of an oligogenic disorder: Hirschsprung's disease [Invited lecture], Joint 6th Human Genome Organization (HUGO) Pacific Meeting and 7th Asia-Pacific Human Genetics Conference (HUGO-AP 2006), Taipei, Taiwan, 6-10 March 2006. 2006.

Tam P.K.H., Diagnosis and treatment of Hirschsprung's disease and related conditions [Invited Lecture], International Surgical Weeik ISW2005, Durban, South Africa, 21-25 August 2005. 2005.

Tam P.K.H., Genomics and Stem Cell in Surgery [Invited Lecture], Paediatric Surgeon of the Year 2006, Department of Paediatric Surgery, Medical University of Graz, Austria, 21 March 2006. 2006.

Tam P.K.H., Honorary Professor (June 2006 - 2009), 深圳市兒童醫院, 2006.

Tam P.K.H. and Wong K.K.Y., Infantile hypertrophic pyloric stenosis, In: DM Burge, DM Griffiths, HA Steinbrecher, RA Wheeler, Paediatric Surgery. London, U.K., Hodder Arnold, 2005, Chapter 22, 2nd Edition: 191-195.

Tam P.K.H. and Wong K.K.Y., Instruments used in rigid and flexible endoscopy, In: A Najmaldin, S Rothenberg, D Crabbe, S Beasley, Operative Endoscopy and Endoscopic Surgery in Infants and Children. London, U.K., Hodder Arnold, 2005, Chapter 5: 23-29.

Tam P.K.H., Laparoscopic hernioplasty in children [Invited Lecture], 7th International Paediatric Surgical Week: Progress in Paediatric Surgery, Kuhtai, Austria, 11-18 March 2006. 2006.

Tam P.K.H., Medical education and training [Invited Lecture - PVC], MGH-Nature-PKU Forum 2005, "Molecular Medicine and Biotechnology in China" Beijing, China, 17-18 October 2005. 2005.

Tam P.K.H., Paediatric Surgery, In: Fundamentals of Surgical Practice, Kingsnorth A, Majid A (eds). 2nd Edition. Cambridge, U.K., Cambridge Unviersity Press, 2006, Chapter 23: 493-523.

Tam P.K.H., Poon R.T.P., Yang Z. and Fan S.T., mTOR inhibitor enhances chemosensitivity of hepatocellular carcinoma (Abstract), The 97th Annual Meeting of the American Association of Cancer Research, Washington D.C., U.S.A., 1 - 5 April 2006.

The International HapMap Consortium &., Tsui L.C., Mak W.W., Sham P.C., Song Y. and Tam P.K.H., A haplotype map of the human genome. The International HapMap Consortium (Co-PI of Hong Kong Centre which responsible 2.5% of genome), Nature. 2005, 437: 1299-1319.

The International HapMap Consortium H.K.U., Tsui L.C., Mak W.W., Sham P.C., Song Y. and Tam P.K.H., A haplotype map of the human genome (Co-PI of Hong Kong Centre which responsible for 2.5% of genome), Nature. 2005, 437: 1299-1320.

To Y.F., Sun R.W.Y., Tam P.K.H., Che C.M. and Liu C.L., Anticancer effect of gold (III) porphyrin in nasopharyngeal carcinoma., 97th Annual Meeting of American Association for Cancer Research, Washington, DC, U.S.A., 1-5 April 2006.

Wong K.K.Y., Fan S.T. and Tam P.K.H., Pitfalls of performing Kasai portoenterostomy: a perspective from a liver transplantation centre, 39th Annual Meeting of the Pacific Association of Pediatric Surgeons, Taipei, Taiwan, 14-18 May 2006.

Wong K.K.Y. and Tam P.K.H., Recent advance in minimally invasive surgery in children, Current Pediatric Reviews. 2006, 2(2): 177-186.

Wong K.K.Y., Fang C. and Tam P.K.H., Selective upper endoscopy for foreign body ingestion in children: an evaluation of management protocol after 282 cases, 39th Annual Meeting of the Pacific Association of Pediatric Surgeons, Taipei, Taiwan, 14-18 May 2006.

Wong K.K.Y., Chung P.H.Y., Lan L.C.L., Lin C.L. and Tam P.K.H., Trends in the prevalence of Helicobacter pylori in symptomatic children in the era of eradication, Journal of Pediatric Surgery. 2005, 40: 1844-1847.

Xie Y., Ren Y. and Tam P.K.H., Dendritic cells (DC) enhance VEGF clearance from neuroblastoma - a mechanism for DC-based immunotherapy, 52nd Annual International Congress of British Association of Paediatric Surgeons, Dublin, Ireland, 12-15 July 2005.

Xu R., Ma H., Li H., Sham M.H., Li E.T.S., Tam P.K.H. and Lam K.S.L., Oral viral vector gene delivery, In: Redberry GW (ed). Trends in Gene Therapy Research. New York, U.S.A., Nova Sciecen Publishers, Inc., 2005, 191-221.

Yip P.K.F., Tam P.K.H. and Li M.K.W., A simple and secure method to fix laparoscopic trocars in children, Journal of Laparoendoscopic & Advanced Surgical Techniques. 2006, 16(2): 188-189.

Researcher : Tang CM

List of Research Outputs

Tang C.M., Poon R.T.P. and Fan S.T., The significance of cyclooxygenase-2 expression in human hepatocellular carcinoma (Review Article), Biomedicine and Pharmacotherapy. 2005, 59(Suppl 2): S311-S316.

Researcher : Tian L

List of Research Outputs

Cai Q., Tian L., Chen Y., Chan V.S.F., Thompson P.W., Lamb J.R. and Tam P.K.H., The effect of PPAR-gamma agonist in HUVEC activation, 30th FEBS Congress & 9th IUBMB Conference, Budapest, Hungary, 2-7 July 2005.

Li X., Tian L., Lamb J.R. and Tam P.K.H., Anti-TGF-beta prevents chronic rejection in a rat orthotopic small bowel transplantation model, 52nd Annual International Congress of British Association of Paediatric Surgeons, Dublin, Ireland, 12-15 July 2005.

Ma L., Chan K.W., Trendell-Smith N.J., Wu A.Y.Y., Tian L., Lam A.C., Lo C.K., Chik S.C.C., Ko K.H., To K.W., Kam C.S.K., Li X., Yang C., Leung S.Y., Ng M.H. and Huang F., Systemic autoimmune disease induced by dendritic cells that have captured necrotic but not apoptotic cells in susceptible mouse strains, In: Ma L, Chan KW, Trendell-Smith NJ, Wu A, Tian L, Lam AC, Chan AK, Lo CK, Chik S, Ko KH, To CK, Kam SK, Li XS, Yang CH, Leung SY, Ng MH, Stott DI, MacPherson GG, Huang FP, European Journal of Immunology (In This Issue highlight, Editorial Comments). 2005, 35(11): 3364-75.

Researcher : Ting ACW

List of Research Outputs

Ho P., Cheng S.W.K., Ting A.C.W. and Poon J.T.C., Improvement of mortality of ruptured abdominal aortic aneurysm patients over 12 years and its relationship with tracheostomy, Annals of Vascular Surgery. 2006, 20(2): 175-182.

Ho P., Yiu W.K., Cheung G.C.Y., Cheng S.W.K., Ting A.C.W. and Poon J.T.C., Systemic review of clinical trials comparing open and endovascular treatment of abdominal aortic aneurysm, Surgical Practice. 2006, 10: 24-37.

Ting A.C.W., Cheng S.W.K., Ho P., Poon J.T.C., Wong Wu L.H. and Cheung G.C.Y., Reduction in deep vein reflux after concomitant subfascial endoscopic perforating vein surgery and superficial vein ablation in advanced primary chronic venous insufficiency, Journal of Vascular Surgery. 2006, 43(3): 546-550.

Ting A.C.W., The 32nd Global Symposium Vascular and Endovascular Issues, Techniques and Horzons, New York, USA, 17-20 November 2005. 2005.

Ting A.C.W., Use of radiofrequency in the treatment of varicose vein, Tung Wah Group of Hospitals (TWGHs) Vascular Symposium, Department of Surgery, Kwong Wah Hospital, Hospital Authority, 6 January 2006. 2006.

Researcher : To JYT

List of Research Outputs

Yang Z., Ngai P.P., Lau C.K., Tam K.H., Ho D.W.Y., To J.Y.T., Poon R.T.P. and Fan S.T., Transient production of interleukin-10 (IL-10) by residual macrophages is crucial for the ischemia/reperfusion injury and long-term allograft survival in liver transplantation (Oral Presentation), The 8th International Congress of the Cell Transplant Society, Milan, Italy, 24 - 26 May 2006.

Researcher : To YF

List of Research Outputs

To Y.F., Sun R.W.Y., Tam P.K.H., Che C.M. and Liu C.L., Anticancer effect of gold (III) porphyrin in nasopharyngeal carcinoma., 97th Annual Meeting of American Association for Cancer Research, Washington, DC, U.S.A., 1-5 April 2006.

Researcher : Toi M

List of Research Outputs

Chow L.W.C., Loo T.Y. and Toi M., Current directions for COX-2 inhibition in breast cancer, Biomedicine & Pharmacoltherapy. 2005, 59: S281-S284.

Chow L.W.C., Cheng C.W.L., Wong J.L.N. and Toi M., Serum lipid profiles in patients receiving endocrine treatment for breast cancer - the results from the Celecoxib Anti-Aromatase Neoadjuvant (CAAN) Trial, Biomedicine & Pharmacotherapy. 2005, 59: S302-S305.

Chow L.W.C., Loo T.Y., Wai C.C.Y., Lui E.L.H., Zhu L. and Toi M., Study of COX-2, Ki67 and p53 expression to predict effectiveness of 5-flurouracil, epirubicin and cyclophosphamide with celecoxib treatment in breast cancer patients, Biomedicine & Pharmacotherapy. 2005, 59: S298-S301.

Chow L.W.C. and Toi M., Translational research in oncology comes timely (Editorial), Biomedicine & Pharmacotherapy. 2005, 59: S263.

Toi M., Horiguchi K., Bando H., Saji S. and Chow L.W.C., Trastuzumab: updates and future issues, Cancer Chemotherapy and Pharmacology. 2005, 1-6.

Researcher : Tong MK

List of Research Outputs

Lee P.Y., Tong M.K., Leung P.L., Chan V.W.M., Leung S.Y.L., Tam P.C., Chan K.W., Lee C.K.F., Yeung W.S.B. and Luk J.M.C., Kidney claudin-19: Localization in distal tubules and collecting ducts and dysregulation in polycystic renal disease, FEBS Letters. 2006, 580(3): 923-31.

Researcher : Tsang STY

List of Research Outputs

Lee N.P., Tsang S.T.Y., Cheng R.H. and Luk J.M.C., Increased solubility of integrin betaA domain using maltose-binding protein as a fusion tag, Protein PEPT Lett. 2006, 13(5): 431-435.

Researcher : Tse TF

List of Research Outputs

Tse T.F. and Chu K.M., RON activation by Macrophage Stimulating Protein decreases the cytotoxic effects of chemotherapy on gastric cancer cells via the MAP kinase pathway, Presented at 10th Research Postgraduate Symposium, Faculty of Medince, The University of Hong Kong, Hong Kong, 3 December 2005.. 2005.

Researcher : Tsui TY

Project Title:	Identification possible role of heme oxygenase-1 on the regulation of T cell activation
Investigator(s):	Tsui TY, Bach F.H.
Department:	Surgery
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2004

Abstract:

To identify the possible role of HO-1 in the process of T cell activation. The findings obtained from this study might be essential in the establishment of the link between cellular defense system and the T cell immunity. HO-1 and its products could be used as novel therapeutic agents to control the disorders of T cell immunity in the future.

List of Research Outputs

Tsui T.Y., Lau C.K., Ma J., Glockzin G., Obed A., Schlitt H.J. and Fan S.T., Adeno-associated virus-mediated heme oxygenase-1 gene transfer suppresses the progression of micronodular cirrhosis in rats, World Journal of Gastroenterology. 2006, 12(13): 2016-2023.

Tsui T.Y., Siu Y.T., Ho D.W.Y., Ma J., Lau C.K., Schlitt H.J. and Fan S.T., Heme oxygenase-1-derived carbon monoxide stimulates adenosine triphosphate generation in human hepatocyte, Biochemical and Biophysical Research Communications. 2005, 336(3): 898-902.

Tsui T.Y., Lau C.K., Ma J., Wu X., Wang Y., Farkas S., Xu R., Schlitt H.J. and Fan S.T., rAAV-mediated stable expression of heme oxygenase-1 in stellate cells: a new approach to attenuate liver fibrosis in rats, Hepatology. 2005, 42(2): 335-342.

Wu J., Ma J., Fan S.T., Schlitt H.J. and Tsui T.Y., Bilirubin derived from heme degradation suppresses MHC class II expression in endothelial cells, Biochemical and Biophysical Research Communications. 2005, 338(2): 890-896.

Researcher : Wang X

Project Title:	Potential mechanisms of wild type p53 in preventing G2 checkpoint abrogation
Investigator(s):	Wang X, Fan ST, Stanbridge EJ
Department:	Centre for the Study of Liver Disease
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004
Completion Date:	10/2005

Abstract:

To investigate the potential mechanisms of wild type p53 in preventing G2 checkpoint aborgation -- whether or how p53 or associated adaptors prevent G2 checkpoint abrogation through regulating chk1 activity.

Project Title:	Cdc25A deregulation checkpoint and its impact on chemotherapy sensitivity in metastatic hepatocellular carcinoma cells.
Investigator(s):	Wang X, Fan ST, Stanbridge EJ
Department:	Surgery
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	11/2005

Abstract:

Objectives: 1. To determine and confirm whether there is a defective Cdc25A-deregulation checkpoint in metastatic as compared to non-metastatic hepatocellular carcinoma (HCC) cell lines. The latter showed a downregulation of Cdc25A, whereas metastatic cells displayed an accumulation of Cdc25A to anticancer drugs in the preliminary study. 2. To understand the mechanisms and consequences of the defective Cdc25A mediated DNA damage checkpoint in metastatic HCC cells, which ultimately will decide cell fate. a) to examine DNA damage response (DDR) activation to anticancer drugs in metastatic HCC cells, such as ATM-Chk2-p53 and ATR-Chk1 pathways, which are upstream regulators of Cdc25A deregulation. b) to investigate whether G1/S checkpoint is defective in metastatic cells due to Cdc25A accumulation. c) to study whether G2/M checkpoint is defective which might be a result of Cdc25A accumulation in metastatic cells. 3. To correlate the Cdc25A mediated DNA damage checkpoint with biological cellular impact, which may undermine cellular response to anticancer treatments in HCC metastatic cells. 4. To investigate whether cancer-associated Cdc25A deregulation, especially its accumulation, may provide selective growth advantages to tumor metastasis. Rationale: The understanding of the molecular responses to anticancer drugs is still incomplete. One way to better understand and improve chemotherapy is to elucidate the pathways activated by currently used anticancer drugs and to study the impact these pathways may have on tumor cells. Cdc25A is one of the key targets of Chk1 and Chk2, and is an essential regulator within the cell cycle machinery. Cdc25A can regulate G1/S and G2/M checkpoints through its downregulation and inhibition of cyclin/CDK complex after DNA damage. Differential impact of various anticancer chemotherapeutics on the Cdc25A-degradation checkpoint pathways and sequential cell sensitivity to anticancer therapy is yet to be further elucidated. Our preliminary study showed that in response to anticancer agents, Cdc25A was accumulated in metastatic HCC cells compared with its downregulation in non-metastatic HCC cells. This phenomenon is novel and important as the deregulated Cdc25A might function on abnormal proliferation, metastatic behaviour, and therapeutic response of metastatic HCC cells. Therefore, it would be of great interest to further understand whether and which cell cycle checkpoints are defective due to deregulation of Cdc25A, and how they correlate with the biological cellular impact to metastatic HCC cells on tumor growth, metastasis, and especially sensitivity to anticancer drugs.

List of Research Outputs

Luk J.M.C., Wang X., Garcia-Barcelo M.M., Leung P.P., Lam B.K.Y., Ho D.W.Y., Yu W.C., Hui C.K. and Lau G., Genetic polymorphisms of liver intestine-cadherin CDH17 are associated with alternative mRNA splicing and increased risk of hepatocellular carcinoma (Abstract), Hepatology. 2005, 42(4): 307A-308A Suppl 1.

Wang X., Redpath J.L., Fan S.T. and Stanbridge E.J., ATR dependent activation of Chk2 and Chk1, Journal of Cellular Physiology. 2006, 208: 613-619.

Wang X., Stanbridge E.J. and Fan S.T., Chemotherapy increases expression of stem cell marker and cell migration in hepatocellular carcinoma (Abstract), The 4th International Society for Stem Cell Research Annual Meeting, Toronto, Canada, 29 June - 1 July 2006.

Wang X. and Fan S.T., Role of Chk1 in preventing G2 checkpoint abrogation in wild type p53 cells (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Researcher : Wang Y

List of Research Outputs

Tsui T.Y., Lau C.K., Ma J., Wu X., Wang Y., Farkas S., Xu R., Schlitt H.J. and Fan S.T., rAAV-mediated stable expression of heme oxygenase-1 in stellate cells: a new approach to attenuate liver fibrosis in rats, Hepatology. 2005, 42(2): 335-342.

Wang Y., Luk J.M.C., Chu A.C.Y., Ikeda K., Man K., Kaneda K. and Fan S.T., TNP-470 blockage of VEGF synthesis is dependent on MAPK/COX-2 signaling pathway in PDGF-BB-activated hepatic stellate cells, Biochemical and Biophysical Research Communications. 2006, 341-(1): 239-244.

Researcher : Wei WI

Project Title:	Intra-arterial chemoradiation for advanced head and neck cancer
Investigator(s):	Wei WI, Sham JST
Department:	Surgery
Source(s) of Funding:	Other Funding Scheme
Start Date:	07/2002

Abstract:

To see if chemotherapy and radiotherapy given can help patients with advanced head and neck cancer.

Project Title:	Modifications of techniques of cochlear implantation
Investigator(s):	Wei WI, Au DKK, Ho WK
Department:	Surgery
Source(s) of Funding:	Other Funding Scheme
Start Date:	09/2002

Abstract:

To study the technique and mode of insertion of cochlear implant aiming to improve the efficacy of the implant.

Project Title:	Management of snoring and OSA
Investigator(s):	Wei WI, Ho WK
Department:	Surgery
Source(s) of Funding:	Other Funding Scheme
Start Date:	09/2002

Abstract:

To find the incidence of snoring and OSA and advance their treatments.

Project Title:	Quantitative analysis of plasma Epstein-Barr-Virus DNA in nasopharyngeal carcinoma after salvage nasopharyngectomy
Investigator(s):	Wei WI
Department:	Surgery
Source(s) of Funding:	Other Funding Scheme
Start Date:	09/2002

Abstract:

To study early detection of recurrence after radiotherapy for nasopharyngeal cancer.

Project Title:	VEGF in nasopharyngeal cancer
Investigator(s):	Wei WI, Kwong DLW, Poon RTP
Department:	Surgery
Source(s) of Funding:	Other Funding Scheme
Start Date:	03/2003

Abstract:

To carry out early detection of nasopharyngeal cancer before radiotherapy and after treatment.

Project Title:	Study the spread of aerosol during tracheostomy or intubation
Investigator(s):	Wei WI, Sham JST, Irwin MG
Department:	Surgery
Source(s) of Funding:	Other Funding Scheme
Start Date:	04/2003

Abstract:

To investigate the distance and pattern of aerosol spread during surgical procedures in application to SARS.

Project Title:	Head and neck course in China - to teach techniques of contemporary operations and patient care for doctors and nurses working in underdeveloped areas in China. This will benefit those poor patients suffereing from head and neck cancer in China
Investigator(s):	Wei WI, Lam LK, Hui Y, Ng WM, Lo E.L.C., Fong W.W.Y., Yue S.W.
Department:	Surgery
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	10/2003

Abstract:

To teach head and neck surgeons in China the contemporary methods of managing patients suffering from head and neck cancer and also to introduce the concept of optimal nursing care for these patients.

Project Title:	Speech rehabilitation after total laryngectomy - self help and mutual help
Investigator(s):	Wei WI, Ho WK, Ng HS, Ho M.L., Kwok I.C.L.
Department:	Surgery
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	10/2003

Abstract:

To visit the hospitals and centres in China where total laryngectomy is performed for patients suffering from cancer of the larynx.

Project Title:	Cochlear implant for 14 profoundly deaf children in China
Investigator(s):	Wei WI, Au DKK, Hui Y
Department:	Surgery
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	10/2003

Abstract:

To help Chinese children who are profoundly deaf in China to receive the cochlear implant, so that they will be able to hear, speak and to receive education effectively.

Project Title:	Cochlear implant for 14 profoundly deaf Chinese children in China
Investigator(s):	Wei WI, Hui Y, Au DKK
Department:	Surgery - Otorhinolaryngology Un
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	07/2005

Abstract:

To provide profoundly deaf in China a chance to received cochlear implant so that they can learn to hear and speak, and receive normal mainstream education.

Project Title:	Speech rehabilitation after total laryngectomy - self help and mutual help
Investigator(s):	Wei WI, Lam PKY, Ho LM, Kwok ICL, Ng HS
Department:	Surgery - Otorhinolaryngology Un
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	07/2005

Abstract:

To provide coaching to another laryngectomee who has learned to speak again after surgery to teach patients to speak again.

Project Title:	Head and neck course in China - to teach techniques of contemporary operations and patient care for doctors and nurses working in relatively underdeveloped areas in China
Investigator(s):	Wei WI, Lam LK, Hui Y, Lam PKY, Li GKH, Fong WWY, Lo ELC, Yue S.W.
Department:	Surgery - Otorhinolaryngology Un
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	07/2005

Abstract:

List of Research Outputs

Au D.K.K., Hui Y., Hao J. and Wei W.I., Electrode Insertion Depth on Cantonese Tone Perception in Hong Kong Cochlear Implant Users, Proceedings, 5th Asia Pacific Symposium on Cochlear Implant and Related Sciences, Hong Kong. 2005, 97.

Chu K.M.Y., Au D.K.K., Hui Y., Chow C.K. and Wei W.I., Short electrode insertion in cochlear implantation: speech perception performance of Cantonese-speaking subjects., Arta Otolaryngol. 2005, 125: 718-724.

Ganly I., Patel S.G., Singh B., Kraus D.H., Bridger P.G., Cantu G., Cheesman A., De Sa G., Donald P., Fliss D.M., Gullane P., Janecka I., Kamata S.E., Kowalski L.P., Levine P.A., Medina Dos Santos L.P., Pradhan S., Schramm V., Snyderman C., Wei W.I. and Shah J.P., Craniofacial resection for malignant paranasal sinus tumors: Report of an International Collaborative Study, Head Neck. 2005, 27: 575-584.

Ho W.K. and Wei W.I., Current Concepts of Chronic Sinusitis Management and Paranasal Sinus Surgery (in press 11/2005), Medical Progress. 2005, 564-571.

Ho W.K. and Wei W.I., Current Concepts of Chronic Sinusitis Management and Paranasal Sinus Surgery, Medical Progress. 2005, 564-571.

Lam P.K.Y., Ho W.K., Ho A.C., Ng W.M., Yuen P.W. and Wei W.I., Long-term performance of indwelling tracheoesophagel speaking valves in Chinese patients undergoing laryngectomy, Arch Otolaryngol Head Neck Surg. 2005, 131: 954-8.

Lam P.K.Y., Wei W.I., Hui Y. and Ho W.K., Prevalence of pH-documented laryngopharyngeal reflux in Chinese patients with clinically suspected reflux laryngitis, American Journal of Otolaryngology. Elsevier, 2006, 27: 186-189.

Liu C.L., Fan S.T., Lo C.M., Wei W.I., Chan S.C., Yong B.H. and Wong J., Operative outcomes of adult-to-adult right lobe live donor liver transplantation: a comparative study with cadaveric whole-graft liver transplantation in a single center, Annals of Surgery. 2006, 243(3): 404-410.

Lund V.J., Wei W.I. and Ho W.K., Ethnic variation in sinonasal anatomy on CT-scanning, Rhinology. 2005, 43(3): 210-214.

Ng W.M. and Wei W.I., Elimination of palatal fistual after the maxillary swing procedure, Head Neck . 2005, 27: 608-612.

Ng W.M. and Wei W.I., Quality of Life of Nasopharyngeal Carcinoma Patients Treated with Nasopharyngectomy, Arch Otolaryngol Head Neck Surg. 2006, 132: 309-316.

Ng W.M. and Wei W.I., Quality of life of patients with recurrent nasopharyngeal carcinoma treated with nasopharyngectomy using the maxillary swing approach, Archives of Otolaryngology, Head and Neck Surgery. American Medical Association, 2006, 132: 309-316.

Wei W.I., Advisor (Nov 2005), The Macau Association of Otorhinolaryngology. 2006.

Wei W.I., Advisory Professor (Jun 2004 - present), 寧夏醫學院附屬醫院, 寧夏, 中國, 2006.

Wei W.I., Advisory Professor (Mar 2002 - present), Zhengzhou University, Henan, China. 2006.

Wei W.I., Alumni Member (1981 - present), Bernard O'Brien Society, The Microsurgery Research Centre, Australia. 2006.

Wei W.I., Assoicate Editor (Jan 1985 - present), Asian Surgical Journal. 2006.

Wei W.I., Audit Committee Member (Oct 2002 - present), International Federation of Oto-Rhino-Laryngological Societies. 2006.

Wei W.I., Chairman (Nov 2004 - Oct 2007), Clinical Ethics and Professional Standard Committee, Hong Kong West Cluster - Hospital Authority. 2006.

Wei W.I., Chief of Service (Nov 1994 - March 2009), Department of ENT, Queen Mary Hospital, Hong Kong. 2006.

Wei W.I., Cluster Chief of Service (Ear, Nose and Throat), Hong Kong West Cluster (Dec 2003 - March 2009), Hong Kong West Cluster, Hospital Authority. 2006.

Wei W.I., Corresonding Fellow (Apr 1995 - present), American Laryngological Association. 2006.

Wei W.I., Corresponding Member (Apr 2001 - May 2006), German Society of Otolarynogology and Head & Neck Surgery. 2006.

Wei W.I., Corresponding member (Apr 1997 - present), American Academy of Otolaryngology - Head and Neck Surgery. 2006.

Wei W.I., Corresponding member (Oct 1998 - present), American Head and Neck Society. 2006.

Wei W.I., Council Member (Nov 2005 - Oct 2007), Hong Kong College of Otorhinolaryngologists. 2006.

Wei W.I., Councilor (Nov 2005 - present), The International Academy of Oral Oncology. 2006.

Wei W.I., Current status of management of anterior skull base tumor - endoscope or scalpel, 2005 Guangdong Symposium & the 9th Annual Conference of Otolaryngology - Head & Neck Surgery of China, Guangzhou, China, 26-27 August. 2005.

Wei W.I., Editorial Board Honorary Member (1999 - present), Chinese Journal of Cancer. 2006.

Wei W.I., Editorial Board Member ( May 1997 - present), The Asean ORL Head and Neck Journal. 2006.

Wei W.I., Editorial Board Member (1996 - present), Chinese Journal of Otolaryngology. 2006.

Wei W.I., Editorial Board Member (2000 -2007), Head & Neck. 2006.

Wei W.I., Editorial Board Member (2003 - present), Medical Progress. 2006.

Wei W.I., Editorial Board Member (2005 - present), Skull Base. 2006.

Wei W.I., Editorial Board Member (Jan 1997 - present), Journal of Clinical Otorhinolaryngology (China). 2006.

Wei W.I., Editorial Board Member (Jan 2005 - Dec 2009), Auris Nasus Larynx. 2006.

Wei W.I., Editorial Board Member (Jun 1995 - present), Australian and New Zealand Journal of Surgery. 2006.

Wei W.I., Editorial Board Member (Nov 1994 - present), The American Journal of Otolaryngology. 2006.

Wei W.I., Editorial Board Member (Oct 1995 - present), Chinese Journal of Clinical Oncology. 2006.

Wei W.I., Elected Council Member (Dec 2005 - Nov 2007), Hong Kong Academy of Medicine. 2006.

Wei W.I., Evolution of mandibular reconstruction, 30th Annual Scientific Meeting of The Royal College of Surgeons of Thailand & 15th Asian Congress of Surgery, Pattaya, Thailand, 20-23 July . 2005.

Wei W.I., Executive Committee Member (Oct 2002 - present), International Federation of Oto-Rhino-Laryngological Societies. 2006.

Wei W.I., Executive Member - representing East Asia (Oct 2002 - present), International Federation of Oto-Rhino-Laryngological Societies. 2006.

Wei W.I., Expert Panel in the Surgery Specialty (Jul 2001 - Jun 2002 & Mar 2004 - Jun 2007), Hospital Authority, Hong Kong. 2006.

Wei W.I., External Assessor (Apr 1999 - Apr 2008), Department of Otorhinolaryngology, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia. 2006.

Wei W.I., Founding Member (Nov 2001 - present), Association of University Surgeons of Asia. 2006.

Wei W.I., Founding Member and Councillor (Mar 2005 - present), The International Academy of Oral Oncology. 2006.

Wei W.I., Guest Professor (Oct 2002 - present), Tongji Medical College, Huazhong University of Science & Technology, China. 2006.

Wei W.I., History of Asian Federation of Laryngectomees' Association, Visit to 哈爾濱醫科大學附屬第三醫院頭頸外科, Harbin, China 29 July - 1 August 2005.

Wei W.I., Honorary Advisor (1987 - present), The New Voice Club of Hong Kong. 2006.

Wei W.I., Honorary Advisor (Dec 1993 - 2006), Hong Kong Patients' Association of Cleft Lip and Palate Children. 2006.

Wei W.I., Honorary Advisor (Feb 1993 - present), Alliance for Patients' Mutual Help Organizations, Hong Kong. 2006.

Wei W.I., Honorary Advisor (Feb 1995 - present), Kin Lok Club, Hong Kong (Nasopharyngeal Carcinoma patient support group). 2006.

Wei W.I., Honorary Advisor (Oct 1995 - present), Driver Rehabiliatoin Service, ReHabAid Centre, Hong Kong Polytechnic University. 2006.

Wei W.I., Honorary Clinical Supervisor - Basic Trainees in Family Medicine (Dec 2004 - Dec 2006), The Hong Kong College of Family Physicians. 2006.

Wei W.I., Honorary Consultant (Dec 1991 - present), Department of Surgery, Queen Mary Hospital. 2006.

Wei W.I., Honorary Consultant in Otorhinolaryngology (Jul 2005 - present), Hong Kong Sanatorium & Hospital. 2006.

Wei W.I., Honorary Director (Dec 1997 - present), The First Medical School, West China University of Medical Sciences Chengdu, Sichuan, China. 2006.

Wei W.I., Honorary Fellow (Feb 2000 - present), Philippine Society of Otolaryngology - Head and Neck Surgery, The Philippines. 2006.

Wei W.I., Honorary Fellow (Mar 2005 - present), Hong Kong College of Otorhinolaryngologists. 2006.

Wei W.I., Honorary Fellow (May 2004 - present), Royal Australasian College of Surgeons. 2006.

Wei W.I., Honorary Fellow (May 2006 - present), German Society of Otorhinolaryngology, Head and Neck Surgery. 2006.

Wei W.I., Honorary Medical Advisor (Aug 1994 - present), The Cancer Crusade Angels Service Society of Hong Kong. 2006.

Wei W.I., Honorary Member (May 2006 - present), German Society of Otolaryngology and Head & Neck Surgery. 2006.

Wei W.I., Honorary Member (Sept 1997 - present), Philippine Academy for Head & Neck Surgery, The Philippines. 2006.

Wei W.I., Honorary Reviewer, Archives of Otolaryngology - Head & Neck Surgery, U.S.A.. 2006.

Wei W.I., Honorary Reviewer, Asian Journal of Surgery, Hong Kong. 2006.

Wei W.I., Honorary Reviewer, Bone Marrow Transplantation. 2006.

Wei W.I., Honorary Reviewer, British Journal of Surgery, U.K.. 2006.

Wei W.I., Honorary Reviewer, Cancer (Interdiscipline International Journal of the American Cancer Society), U.S.A.. 2006.

Wei W.I., Honorary Reviewer, Clinical Cancer Research, U.S.A. . 2006.

Wei W.I., Honorary Reviewer, Head & Neck (Journal for the Sciences and Specialties of the Head and Neck), U.S.A.. 2006.

Wei W.I., Honorary Reviewer, International Journal of Cancer (Official Journal of UICC), Germany. 2006.

Wei W.I., Honorary Reviewer, Oncology (International Journal of Cancer Research and Treatment), Switzerland. 2006.

Wei W.I., Honorary Reviewer, The American Journal of Rhinology, U.S.A.. 2006.

Wei W.I., Honorary Reviewer, The American Journal of Surgery, U.S.A.. 2006.

Wei W.I., Honorary Reviewer, The Hong Kong Practitioner (Journal of Hong Kong College of Family Physicians), Hong Kong. 2006.

Wei W.I., Honorary Reviewer, The Laryngoscope, U.S.A.. 2006.

Wei W.I., Honorary Treasurer (1991 - present), Hong Kong Society of Otorhinolaryngology. 2006.

Wei W.I., International Advisor Board Member, Otolaryngology Head and Neck Surgery - American Academy of Otolaryngology, Head and Neck Surgery. 2006.

Wei W.I., Ferlito A., Rinaldo A., Gourin C.G., Lowry J., Ho W.K., Leemans C.R., Shaha A.R., Suarez C., Clayman G.L., Robbins K.T., Bradley P.J. and Silver C.E., Management of the N0 neck-reference or preference, Oral Oncol.. 2006, 42: 115-22.

Wei W.I., Member (1984 - present), Association of Head & Neck Oncologists of Great Britain. 2006.

Wei W.I. and Wei W.I., Member (1984 - present), Hong Kong Society of Otorhinolaryngology. 2006.

Wei W.I., Member (1985 - present), Otorhinolaryngological Research Society of Great Britain. 2006.

Wei W.I., Member (1987 - present), Asian Oceanic Clinical Oncology Association. 2006.

Wei W.I., Member (1992 - present), Collegium Oto-Rhino-Laryngologicum Amicitiae Sacrum. 2006.

Wei W.I., Member (Jan 2004 - Jan 2007), The Medical Council of Hong Kong. 2006.

Wei W.I., Member (Mar 2003 - present), Hong Kong Adventist Hospital Foundation Children's Hearing Fund. 2006.

Wei W.I., Member (Nov 1992 - present), Hong Kong Institute of Science. 2006.

Wei W.I., Member of Ad Hoc Committee Oncology and Head and Neck Surgery (Oct 2002 - present), International Federation of Oto-Rhino-Laryngological Societies. 2006.

Wei W.I., Member, the Board of Governors (Aug 2005 - Jul 2007), Prince Philip Dental Hospital. 2006.

Wei W.I., Nasopharyngeal Cancer, Head & Neck Surgery - OTOLARYNGOLOGY. USA, Lippincott Williams & Wilkins, a Wolters Kluwer Business, 2006, 2: 1657-1671.

Wei W.I., National Delegate - Hong Kong Representative (1987 - present), Asian Federation of Laryngectomees Association. 2006.

Wei W.I., National Delegate, Newsletter Editor, International Federation of Head and Neck Oncologic Societies. 2006.

Wei W.I., Newsletter Editor (Apr 2001 - present), International Federation of Head & Neck Oncologic Societies. 2006.

Wei W.I., Obstructive sleep apnoea and rhinitis, Allergy and Asthma Convention, Beijing, China, 13 August. 2005.

Wei W.I., Yuen P.W., Fan Y.W., Lam L.K. and Wong L.Y., Outcome Analysis of Patients with Craniofacial Resection: Hong Kong Experience, Australia New Zealand Journal of Surgery. New Zealand, Royal Australasian College of Surgeons, 2005, 76: 313-317.

Wei W.I., Hui Y. and Ho W.K., Prevalence of pH-documented laryngopharyngeal reflux in Chinese patients with clinically suspected reflux laryngitis (in press), Am J Otolaryngol . 2005, 186-189.

Wei W.I., Representative of the Hong Kong Society of Otorhinolaryngology, Head and Neck Surgery (Mar 2005 - present), International Federation of Oto-rhino-laryngological Societies. 2006.

Wei W.I., Secretary General, International Federation of Head and Neck Oncologic Societies. 2006.

Wei W.I., Skull Base, Editorial Board Member 2005. 2005.

Wei W.I., Specialist Consultant, School of Otolaryngology, Capital University of Medical Sciences, Beijing, China. 2006.

Wei W.I., Surgical management of snoring, Hong Kong Allergy Convention, Hong Kong, 7 August. 2005.

Wei W.I., The medicine system in Hong Kong, Visit to 哈爾濱醫科大學附屬第三醫院頭頸外科, Harbin, China, 29 July-1 August 2005.

Wei W.I., Treasurer (1977 - present), Asian Surgical Association . 2006.

Wei W.I., Use of free flaps in head and neck surgery, Visit to 哈爾濱醫科大學附屬第三醫院頭頸外科Harbin, China, 29 July - 1 August 2005.

Wei W.I., Visiting Professor (Nov 2004 - Nov 2006), Guiyang Medical College, Guiyang City, Guizhou Province, China. 2006.

Wei W.I., 第八屆編委 (Nov 2005 - present), 中華耳鼻咽喉頭頸外科雜誌, 2006.

Wei W.I., 第三屆編委 (Jan 2006 - Dec 2009), <<中國耳鼻咽喉顱底外科>>雜誌, 2006.

Wei W.I., 第三屆學術委員會委員 (Apr 2006 - Mar 2008), 中國醫學文摘耳鼻咽喉科學, 2006.

Wong T.S., Kwong D.L., Sham J.S., Wei W.I. and Yuen P.W., Methylation status of Reprimo in head and neck carcinomas, Int J Cancer. 2005, 117: 697.

Researcher : Wong J

Project Title:	Randomised prospective trial comparing the use of neck drain after oesophagectomy with cervical anastomosis
Investigator(s):	Wong J, Law SYK
Department:	Surgery
Source(s) of Funding:	Other Funding Scheme
Start Date:	01/1994

Abstract:

To evaluate the need of routine cervical drains after oesophagectomy.

Project Title:	Thoracoscopic cardiomyotomy for achalasia
Investigator(s):	Wong J, Law SYK
Department:	Surgery
Source(s) of Funding:	Other Funding Scheme
Start Date:	01/1994

Abstract:

To study the efficacy of a new approach of surgical treatment for achalasia, using endoscopic instruments via tiny incisions into the thoracic cavity, thus avoiding the complications and discomforts if long surgical incision from traditional surgical approach.

Project Title:	Randomised prospective trial investigating the effect of preoperative chemo-radiation for resectable carcinoma of the oesophagus
Investigator(s):	Wong J, Law SYK
Department:	Surgery
Source(s) of Funding:	Other Funding Scheme
Start Date:	01/1995

Abstract:

To evaluate the use of preoperative chemo-radiation for treatment of oesophageal cancer.

Project Title:	Prospective study of the use of chemoradiotherapy in the treatment of advanced carcinoma of the oesophagus not suitable for resection
Investigator(s):	Wong J, Law SYK
Department:	Surgery
Source(s) of Funding:	Other Funding Scheme
Start Date:	01/1995

Abstract:

To evaluate the use of chemoradiotherapy in the treatment of advanced carcinoma of the oesophagus not suitable for resection.

Project Title:	Retrospective and prospective study on the use of chemotherapy and chemoradiotherapy in the treatment of recurrent disease after oesophagectomy for cancer
Investigator(s):	Wong J, Law SYK
Department:	Surgery
Source(s) of Funding:	Other Funding Scheme
Start Date:	01/1995

Abstract:

To evaluate the use of chemotherapy and spare chemoradiotherapy in the treatment of recurrent disease.

Project Title:	Thoracoscopic oesophagectomy for carcinoma of the oesophagus
Investigator(s):	Wong J, Law SYK
Department:	Surgery
Source(s) of Funding:	Other Funding Scheme
Start Date:	04/1996

Abstract:

To study the efficacy of an endoscopic approach in the resection of oesophageal carcinoma without the necessity of a conventional open thoracotomy. This would have the benefit of decreasing the incidence of pulmonary complications and deaths related to these complications associated with conventional surgery. Thoracoscopic oesophagectomy will also be compared with the transhiatal approach to see whether there are differences in morbidit, mortality and survival.

Project Title:	The use of endoscopic ultrasound in staging of esophageal cancer
Investigator(s):	Wong J, Chu KM, Law SYK
Department:	Surgery
Source(s) of Funding:	Other Funding Scheme
Start Date:	07/1996

Abstract:

To evaluate the accuracy and use of endoscopic ultrasound in the management of esophageal cancer.

Project Title:	Clinical significance of hepatocyte growth factor in esophageal squamous cell carcinoma
Investigator(s):	Wong J, Law SYK, Ren Y
Department:	Surgery
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Abstract:

To investigate whether relationships exist between serum HGF levels and angiogenic factors, clinico- pathological factors, and long-term survival; to study whether HGF correlates with angiogenic factors such as VEGF and IL-8 in patients' sera; to detect the possible sources of HGF in ESCC specimens.

List of Research Outputs

Chan K.W., Lee P.Y., Lam A.K.Y., Law S.Y.K., Wong J. and Srivastava G., Clinical relevance of Fas expression in oesophageal squamous cell carcinoma, Journal of Clinical Pathology . 2006, 59(1): 101-4.

Chan K.W., Lee P.Y., Lam A.K.Y., Law S.Y.K., Wong J. and Srivastava G., Fas expression is a favorable prognostic factor in esophageal squamous cell carcinoma, The Fourth Asia-Pacific International Academy of Pathology Congress (IAP2005), 22-26 August 2005, Beijing, China. 2005.

Cheung H.Y.S., Law S.Y.K., Wong K.H., Kwok K.F. and Wong J., Spontaneous pneumomediastinum in a scuba diver (Case Report), Hong Kong Medical Journal. 2006, 12(2): 152-153.

Fatima S., Chui C.H., Tang W.K., Hui K.S., Au H.W., Li W.Y., Wong M.M., Cheung F., Tsao G.S.W., Lam K.Y., Beh S.L., Wong J., Law S.Y.K., Srivastava G., Ho K.P., Chan A.S. and Tang J.C.O., Transforming capacity of two novel genes JS-1 and JS-2 located in chromosome 5p and their overexpression in human esophageal squamous cell carcinoma, International Journal of Molecular Medicine. 2006, 17(1): 159-170.

Ferri L.E., Law S.Y.K., Wong K.H., Kwok K.F. and Wong J., The influence of technical complications on postoperative outcome and survival after esophagectomy, Annals of Surgical Oncology. 2006, 13(4): 557-564.

Lai K.C., Chu K.M., Hui W.M., Wong B.C.Y., Hu H.C., Wong W.M.R., Chan O.O.A., Wong J. and Lam S.K., Celecoxib compared with lansoprazole and naprosyn to prevent gastrointestinal ulcer complications, American Journal of Medicine. 2005, 118: 1271-1278.

Law S.Y.K. and Wong J., Case 16: Cervical esophageal cancer, In: Khatri V.P. (eds), Clinical Scenarios in Surgery: Clinical Scenarios in Surgical Oncology . Philadelphia, USA, Lippincott Williams & Wilkins, 2006, 63-67.

Law S.Y.K. and Wong J., Case 17: Squamous cell cancer of the mid-esophagus, In: Khatri V.P. (eds), Clinical Scenarios in Surgery: Clinical Scenarios in Surgical Oncology . Philadelphia, USA, Lippincott Williams & Wilkins, 2006, 68-73.

Law S.Y.K. and Wong J., Chapter 11: Tumours of the oesophagus, In: Tjandra J.J., Clunie G.J.A., Kaye A.H, Smith J.A. (eds), Textbook of Surgery, Third Edition . Melbourne, Australia, Blackwell Publishing, 2006, 83-92.

Law S.Y.K., Kwong D.L.W., Wong K.H., Kwok K.F., Sham J.S.T. and Wong J., Neoadjuvant chemoradiation changes the relationship between pT and pN status, and their prognostic significance in esophageal cancer (Abstract), Forty-Seventh Annual Meeting of The Society for Surgery of the Alimentary Tract (DDW), Los Angeles, 20-24 May. 2006.

Law S.Y.K., Kwong D.L.W., Wong K.H., Kwok K.F., Sham J.S.T. and Wong J., The effects of neoadjuvant chemoradiation on the relationship between PT and PN status, and their prognostic significance in esophageal cancer (Poster Abstract), 10th World Congress of the International Society for Diseases of the Esophagus ISDE, Adelaide, Australia, 22-25 February. 2006.

Liem M.S.L., Liu C.L., Tso W.K., Lo C.M., Fan S.T. and Wong J., Portal vein embolisation prior to extended right-sided hepatic resection, Hong Kong Medical Journal. 2005, 11(5): 366-372.

Liu C.L., Fan S.T., Cheung S.T., Lo C.M., Ng I.O.L. and Wong J., Anterior approach versus conventional approach right hepatic resection for large hepatocellular carcinoma: a prospective randomised controlled study (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Liu C.L., Fan S.T., Lo C.M., Tso W.K., Wong Y., Poon R.T.P., Lam C.M., Wong B.C.Y. and Wong J., Clinicobiochemical prediction of biliary cause of acute pancreatitis in the era of endoscopic ultrasonography, Alimentary Pharmacology and Therapeutics. 2005, 22(5): 423-431.

Liu C.L., Fan S.T., Lo C.M., Tso W.K., Wong Y., Poon R.T.P., Lam C.M., Wong B.C.Y. and Wong J., Comparison of early endoscopic ultrasonography and endoscopic retrograde cholangiopancreatography in the management of acute biliary pancreatitis: a prospective randomized study, Clinical Gastroenterology and Hepatology. 2005, 3(12): 1238-1244.

Liu C.L., Fan S.T., Lo C.M., Wei W.I., Chan S.C., Yong B.H. and Wong J., Operative outcomes of adult-to-adult right lobe live donor liver transplantation: a comparative study with cadaveric whole-graft liver transplantation in a single center, Annals of Surgery. 2006, 243(3): 404-410.

Lo C.M., Cheung C.K.Y., Lau G., Yuen R.M.F., Liu C.L., Chan S.H.C., Fan S.T. and Wong J., Significance of hepatitis B virus genotype in liver transplantation for chronic hepatitis B, American Journal of Transplantation. Blackwell, 2005, 5: 1893-900.

Ren Y., Cao B., Law S.Y.K., Xie Y., Lee P.Y., Cheung C.M., Chen Y., Huang X., Chan H.M., Zhao P., Luk J.M.C., Vande Woude G. and Wong J., Hepatocyte growth factor promotes cancer cell migration and angiogenic factors expression: a prognostic marker of human esophageal squamous cell carcinomas, Clinical Cancer Research. 2005, 11(17): 6190-6197.

Ren Y., Law S.Y.K., Huang X., Lee P.Y., Bacher M., Srivastava G. and Wong J., Macrophage migration inhibitory factor stimulates angiogenic factor expression and correlates with differentiation and lymph node status in patients with esophageal squamous cell carcinoma, Annals of Surgery. 2005, 242(1): 55-63.

Tang W.K., Fatima S., Chui C.H., Ou T.M., Hui K.S., Wong M.M., Wong J., Law S.Y.K., Tsao G.S.W., Lam A.K.Y., Beh S.L., Srivastava G., Ho K.P. and Tang J.C.O., Oncogenic properties of a novel gene located in chromosome 5p and its overexpression in human esophageal squamous cell carcinoma, Proceedings of the 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress of Biochemistry and Molecular Biology, Kyoto, Japan, June 18-23, 2006.

Tong M., Hung W.K., Law S.Y.K., Wong K.H., Kwok K.F. and Wong J., Esophageal hematoma (Case Report), Diseases of the Esophagus. 2006, 19(3): 200-202.

Wong J. and Law S.Y.K., Anastomotic stricture following esophagectomy (Seminar), 10th World Congress of the International Society for Diseases of the Esophagus ISDE, Adelaide, Australia, 22-25 February. 2006.

Wong J., Complications of esophageal resection: inevitable but not mortal, Conference on Cancer of the Lung and Mediastinum, Kuwait, 14-16 November. 2005.

Wong J., Esophagectomy for cancer: a proposal for international best practice, CATS F.G. Pearson Lectureship, Canadian Surgery FORUM canadien de chirurgie 2005, Montreal, Quebec, 8-11 September. 2005.

Wong J., Is there a place for resection in esophageal cancer in 2016?, The 65th Scientific Meeting of the Taiwan Surgical Association, Taipei, Taiwan, 25-26 March. 2006.

Wong J., Management of resectable cancer: management of squamous cell cancer (Abstract), Post-Graduate Courses, World Congress of Gastroenterology, Canadian Surgery FORUM canadien de chirurgie 2005, Montreal, Quebec, 10-14 September. 2005.

Wong J., Squamous cell carcinoma - two-field and three-field lymphadenectomy, Progress in Esophageal Diseases - Meet the Experts, Mainz, Germany, 23-24 June. 2006.

Wong J., Surgeon versus institution: contributions to outcome after esophagectomy, Brittany Conference on Esophageal Cancer, Bretesche, France, 25-28 June. 2006.

Wong J., Surgical expertise and outcome of esophageal cancer surgery, International Surgical Week ISW 2005, Durban, South Africa, 21-25 August. 2005.

Wong J., Toward zero operative mortality: should this be the benchmark?, TWH 135th Anniversity Academic Symposium - "Quest for Excellence", Department of Surgery, University of Hong Kong Medical Centre, Tung Wah Hospital, 19-20 November. 2005.

Wong J., What has improved outcome of cancer surgery in 40 years?, 40-Year Reunion, The University of Sydney, Sydney, Australia, 27 January. 2006.

Wong J., World perspective: the epidemiology of esophageal cancer (Abstract), Post-Graduate Courses, World Congress of Gastroenterology, Canadian Surgery FORUM canadien de chirurgie 2005, Montreal, Quebec, 10-14 September. 2005.

Wong M.L.Y., Tao Q., Fu L., Wong K.Y., Qiu G.H., Law F.B.F., Tin P.C., Cheung W.L., Lee P.Y., Tang J.C.O., Tsao G.S.W., Lam A.K.Y., Law S.Y.K., Wong J. and Srivastava G., Aberrant promoter hypermethylation and silencing of the critical 3p21 tumour suppressor gene, RASSF1A, in Chinese oesophageal squamous cell carcinoma, International Journal of Oncology. 2006, 28(3): 767-73.

Yeung Y.P., Lo C.M., Liu C.L., Wong B.C.Y., Fan S.T. and Wong J., Natural history of untreated nonsurgical hepatocellular carcinoma, American Journal of Gastroenterology. 2005, 100(9): 1995-2004.

Researcher : Wong KF

List of Research Outputs

Luk J.M.C. and Wong K.F., Monoclonal antibodies as targeting and therapeutic agents: prospects for liver transplantation, hepatitis and hepatocellular carcinoma, Clinical Experience of Pharmacology Physiology. 2006, 33 (5-6): 482-488.

Wong K.F., Fan S.T. and Luk J.M.C., Immunochemical characterization of tripterygium wifordii (triptolide, triptonide and synthetic racemic derivatives) immunosupppressive properties in allogenic mixed lymphocyte reaction (Abstract) (Best poster presentation award), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25 - 28 March 2006. 2006.

Wong K.F., Fan S.T. and Luk J.M.C., Immunochemical characterization of tripterygium wilfordii (triptolide, triptonide and synthetic racemic derivatives) immunosuppressive properties in allogenic mixed lymphocyte reaction (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A219.

Researcher : Wong KKY

List of Research Outputs

Lan L.C.L., Yip P.K.F., Wong K.K.Y. and Tam P.K.H., Comparison of laparaoscopic vs open pyeloplasty in children, 39th Annual Meeting of the Pacific Association of Pediatric Surgeons, Taipei, Taiwan, 14-18 May 2006.

Tam P.K.H. and Wong K.K.Y., Infantile hypertrophic pyloric stenosis, In: DM Burge, DM Griffiths, HA Steinbrecher, RA Wheeler, Paediatric Surgery. London, U.K., Hodder Arnold, 2005, Chapter 22, 2nd Edition: 191-195.

Tam P.K.H. and Wong K.K.Y., Instruments used in rigid and flexible endoscopy, In: A Najmaldin, S Rothenberg, D Crabbe, S Beasley, Operative Endoscopy and Endoscopic Surgery in Infants and Children. London, U.K., Hodder Arnold, 2005, Chapter 5: 23-29.

Wong K.K.Y., Fan S.T. and Tam P.K.H., Pitfalls of performing Kasai portoenterostomy: a perspective from a liver transplantation centre, 39th Annual Meeting of the Pacific Association of Pediatric Surgeons, Taipei, Taiwan, 14-18 May 2006.

Wong K.K.Y. and Tam P.K.H., Recent advance in minimally invasive surgery in children, Current Pediatric Reviews. 2006, 2(2): 177-186.

Wong K.K.Y., Fang C. and Tam P.K.H., Selective upper endoscopy for foreign body ingestion in children: an evaluation of management protocol after 282 cases, 39th Annual Meeting of the Pacific Association of Pediatric Surgeons, Taipei, Taiwan, 14-18 May 2006.

Wong K.K.Y., Chung P.H.Y., Lan L.C.L., Lin C.L. and Tam P.K.H., Trends in the prevalence of Helicobacter pylori in symptomatic children in the era of eradication, Journal of Pediatric Surgery. 2005, 40: 1844-1847.

Researcher : Wong SY

List of Research Outputs

Cheung S.T., Wong S.Y., Lee Y.T. and Fan S.T., GEP upregulates wild-type p53 in hepatocellular carcinoma, Oncology Reports. 2006, 15(6): 1507-1511.

Cheung S.T., Wong S.Y. and Fan S.T., Granulin-epithelin precursor and p53 in hepatocellular carcinoma (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A82.

Researcher : Wong SY

List of Research Outputs

Cheung S.T., Wong S.Y., Lee Y.T. and Fan S.T., GEP upregulates wild-type p53 in hepatocellular carcinoma, Oncology Reports. 2006, 15(6): 1507-1511.

Researcher : Wong TS

List of Research Outputs

Wong T.S., Kwong D.L., Sham J.S., Wei W.I. and Yuen P.W., Methylation status of Reprimo in head and neck carcinomas, Int J Cancer. 2005, 117: 697.

Researcher : Wong Wu LH

List of Research Outputs

Ting A.C.W., Cheng S.W.K., Ho P., Poon J.T.C., Wong Wu L.H. and Cheung G.C.Y., Reduction in deep vein reflux after concomitant subfascial endoscopic perforating vein surgery and superficial vein ablation in advanced primary chronic venous insufficiency, Journal of Vascular Surgery. 2006, 43(3): 546-550.

Researcher : Xiao J

List of Research Outputs

Man K., Lo C.M., Ng T.P., Xiao J., Sun K.W., Su M. and Fan S.T., Significant activation of cell invasion, migration and angiogenesis pathways in small-for-size grafts may potentially increase tumour recurrence after living donor liver transplantation (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Researcher : Xie Y

List of Research Outputs

Ren Y., Xie Y. and Tam P.K.H., Dendritic cell (DC) enhances VEGF clearance from neuroblastoma - a mechanism for DC-based immunotherapy., 97th Annual Meeting of American Association for Cancer Research, Washington, DC, U.S.A., 1-5 April 2006.

Ren Y., Cao B., Law S.Y.K., Xie Y., Lee P.Y., Cheung C.M., Chen Y., Huang X., Chan H.M., Zhao P., Luk J.M.C., Vande Woude G. and Wong J., Hepatocyte growth factor promotes cancer cell migration and angiogenic factors expression: a prognostic marker of human esophageal squamous cell carcinomas, Clinical Cancer Research. 2005, 11(17): 6190-6197.

Ren Y., Chan H.M., Fan J., Xie Y., Chen Y., Li W., Jiang G., Liu Q., Meinhardt A. and Tam P.K.H., Inhibition of tumor growth and metastasis in vitro and in vivo by targeting macrophage migration inhibitory factor in human neuroblastoma, Oncogene. 2006, 25(25): 3501-3508.

Xie Y., Ren Y. and Tam P.K.H., Dendritic cells (DC) enhance VEGF clearance from neuroblastoma - a mechanism for DC-based immunotherapy, 52nd Annual International Congress of British Association of Paediatric Surgeons, Dublin, Ireland, 12-15 July 2005.

Researcher : Xie Y

List of Research Outputs

Researcher : Xu R

Project Title:	Oral gene therapy of tumors by using recombinant AAV-TRAIL viral vectors
Investigator(s):	Xu R, Kung H
Department:	Institute of Molecular Biology
Source(s) of Funding:	Matching Fund for Hi-Tech Research and Development Program of China (863 Projects)
Start Date:	05/2002

Abstract:

To study tumor therapy by using recombinant AAV.

Project Title:	Peroral transduction of hepatocytes for diabetes gene therapy
Investigator(s):	Xu R, Lam KSL
Department:	Institute of Molecular Biology
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	10/2002

Abstract:

A major goal of gene therapy for Diabetes Mellitus (DM) is to restore long-term euglycemia. This study shall focus on clarifying the adeno-associated virus (AAV) vector transportation pathway from stomach to liver after oral administration. The research team will extend their previous study further to develop chimeric glucose- and insulin-sensitive promoters and insert them into the existing AAV vector system.

Project Title:	Preclinical study of lung cancer therapy using recombinant adeno-associate virus vector
Investigator(s):	Xu R
Department:	Institute of Molecular Biology
Source(s) of Funding:	Matching Fund for Hi-Tech Research and Development Program of China (863 Projects)
Start Date:	04/2003

Abstract:

To carrry out preclinical study of lung cancer therapy using recombinant adeno-associate virus vector.

List of Research Outputs

Researcher : Xu Y

List of Research Outputs

Liu Y., Poon R.T.P., Li L., Qian X., Chen Y., Xu Y., Sun H.C., Tang Z.Y. and Fan S.T., Synergistic inhibitory effects of PTK787/ZK222584 and interferon-alfa on hepatocellular carcinoma with metastatic potential (Abstract), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A94.

Researcher : Yang Z

Project Title:	Evaluation of HIF-1α and VEGF expression after hypoxia and chemotherapy in hepatocellular carcinoma
Investigator(s):	Yang Z, Fan ST, Poon RTP
Department:	Centre for the Study of Liver Disease
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004
Completion Date:	10/2005

Abstract:

To investigate the expression pattern of HIF-1α and VEGF in serially collected tissue and plasma samples after hypoxia and chemotherapy in an orthotopic HCC model in rat.

Project Title:	Combination of mTOR inhibitor with chemo-cytotoxic agent for the treatment of hepatocellular carcinoma
Investigator(s):	Yang Z, Poon RTP
Department:	Surgery
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2006
Completion Date:	12/2006

Abstract:

Objective: Hepatocellular carcinoma (HCC) ranks fifth in frequency worldwide among all malignancies and causes one million deaths annually. Hepatic resection and liver transplantation are the only two approaches that may cure HCC, but the majority of patients present with an advanced stage beyond surgical treatment. Chemotherapy is widely employed to treat unresectable HCC, but the efficacy is not satisfactory due to the resistance of tumor cells to the chemo-cytotoxic agents. The mammalian target of rapamycin (mTOR) has been demonstrated to play an important role in the chemo-resistant pathways in some tumors. Therefore, we design the present study to evaluate the therapeutic potential of mTOR inhibition on enhancement of chemo-sensitivity of HCC tumor cells to chemo-cytotoxic agents.

List of Research Outputs

Lum C.T., Yang Z., Li H.Y., Sun R.W.Y., Fan S.T., Poon R.T.P., Lin M.C., Che C.M. and Kung H., Gold(III) compound is a novel chemocytotoxic agent for hepatocellular carcinoma, International Journal of Cancer. 2006, 118(6): 1527-1538.

Tam P.K.H., Poon R.T.P., Yang Z. and Fan S.T., mTOR inhibitor enhances chemosensitivity of hepatocellular carcinoma (Abstract), The 97th Annual Meeting of the American Association of Cancer Research, Washington D.C., U.S.A., 1 - 5 April 2006.

Yang Z., Ho D.W.Y., Lau C.K., Lam C.T., Lum C.T., Poon R.T.P. and Fan S.T., Allograft inflammatory factor-1 (AIF-1) is crucial for the survival and pro-inflammatory activity of macrophages, International Immunology. 2005, 17(11): 1391-1397.

Yang Z., Liu Y., Ho D.W.Y., Lau C.K., Poon R.T.P. and Fan S.T., Blockade of vascular endothelial growth factor (VEGF) receptor enhances the therapeutic efficacy of hypoxia and chemotherapy in hepatocellular carcinoma (Poster Presentation), The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2 - 3 December 2005.

Yang Z., Chairperson - Poster Section, The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2 - 3 December 2005. 2005.

Yang Z., Delayed immunosuppresion induces long-term liver allograft survival through interleukin-10 (IL-10) dependent manner (Invited Lecture), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006. 2006.

Yang Z., Lau C.K., Ngai P.P., Ho D.W.Y., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Delayed immunosuppression induces long-term liver allograft survival through interleukin-10 (IL-10) dependent manner (Abstract), The 7th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 21 January 2006.

Yang Z., Distinguished Scientific Award - "Blockade of vascular endothelial growth factor (VEGF) receptor enhances the therapeutic efficacy of hypoxia and chemotherapy in hepatocellular carcinoma", The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2-3 December 2005. 2005.

Yang Z., Poon R.T.P. and Fan S.T., Interplay between BDNF and platelet in hepatocellular carcinoma (Poster Presentation), The 97th Annual Meeting of the American Association of Cancer Research, Washington D.C., U.S.A., 1 - 5 April 2006.

Yang Z., Lau C.K., Ngai P.P., Ho D.W.Y., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Short-term cardiotrophin-1 (CT-1) rescues marginal cirrhotic liver remnant after major hepatectomy without increasing the risk of tumor recurrence (Oral Presentation), Shanghai-Hong Kong International Liver Congress 2006, Shanghai, China, 25-28 March 2006. Journal of Gastroenterology and Hepatology. 2006, 21(Suppl 2): A92.

Yang Z., Ngai P.P., Lau C.K., Tam K.H., Ho D.W.Y., To J.Y.T., Poon R.T.P. and Fan S.T., Transient production of interleukin-10 (IL-10) by residual macrophages is crucial for the ischemia/reperfusion injury and long-term allograft survival in liver transplantation (Oral Presentation), The 8th International Congress of the Cell Transplant Society, Milan, Italy, 24 - 26 May 2006.

Researcher : Yang ZF

Project Title:	Evaluation of HIF-1α and VEGF expression after hypoxia and chemotherapy in hepatocellular carcinoma
Investigator(s):	Yang Z, Fan ST, Poon RTP
Department:	Centre for the Study of Liver Disease
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004
Completion Date:	10/2005

Abstract:

To investigate the expression pattern of HIF-1α and VEGF in serially collected tissue and plasma samples after hypoxia and chemotherapy in an orthotopic HCC model in rat.

Project Title:	Combination of mTOR inhibitor with chemo-cytotoxic agent for the treatment of hepatocellular carcinoma
Investigator(s):	Yang Z, Poon RTP
Department:	Surgery
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2006
Completion Date:	12/2006

Abstract:

List of Research Outputs

Researcher : Yau TO

Project Title:	The role of HDPR1, a novel inhibitor of the WNT/β-catenin signalling pathway, in hepatocellular carcinoma
Investigator(s):	Yau TO, Fan ST, Ng IOL
Department:	Centre for the Study of Liver Disease
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004
Completion Date:	10/2005

Abstract:

To study the expression of HDPR1 at mRNA levels in human HCCs and HCC cell lines; to investigate the common mechanisms, such as promoter hypermethylation and loss of heterozygosity, by which the expression of HDPR1 in HCC is downregulated; to study the function of HDPR1 in HCC cell lines.

List of Research Outputs

Researcher : Yeung YP

List of Research Outputs

Yeung Y.P., Lo C.M., Liu C.L., Wong B.C.Y., Fan S.T. and Wong J., Natural history of untreated nonsurgical hepatocellular carcinoma, American Journal of Gastroenterology. 2005, 100(9): 1995-2004.

Researcher : Yip PKF

List of Research Outputs

Lan L.C.L., Yip P.K.F., Wong K.K.Y. and Tam P.K.H., Comparison of laparaoscopic vs open pyeloplasty in children, 39th Annual Meeting of the Pacific Association of Pediatric Surgeons, Taipei, Taiwan, 14-18 May 2006.

Yip P.K.F., Tam P.K.H. and Li M.K.W., A simple and secure method to fix laparoscopic trocars in children, Journal of Laparoendoscopic & Advanced Surgical Techniques. 2006, 16(2): 188-189.

Researcher : Yip YS

List of Research Outputs

Yip Y.S. and Chow L.W.C., Clinical experience with decetaxel for chinese breast cancer patients: hematological toxicity profiles, Breast Cancer. 2006, 13: 192-196.

Researcher : Yiu WK

List of Research Outputs

Ho P., Yiu W.K., Cheung G.C.Y., Cheng S.W.K., Ting A.C.W. and Poon J.T.C., Systemic review of clinical trials comparing open and endovascular treatment of abdominal aortic aneurysm, Surgical Practice. 2006, 10: 24-37.

Researcher : Yu WC

List of Research Outputs

Luk J.M.C., Wang X., Garcia-Barcelo M.M., Leung P.P., Lam B.K.Y., Ho D.W.Y., Yu W.C., Hui C.K. and Lau G., Genetic polymorphisms of liver intestine-cadherin CDH17 are associated with alternative mRNA splicing and increased risk of hepatocellular carcinoma (Abstract), Hepatology. 2005, 42(4): 307A-308A Suppl 1.

Researcher : Yuan Z

List of Research Outputs

Garcia-Barcelo M.M., So M.T., Lau K.C., Leon Y.Y., Yuan Z., Cai W., Lui V.C.H., Fu M., Herbrick J.A., Gutter E., Proud V., Li L., Pierre-Louis J., Aleck K., van Heurn E., Belloni E., Scherer S.W. and Tam P.K.H., Population differences in the polyalanine domain and 6 new mutations in HLXB9 in patients with Currarino syndrome, Clinical Chemistry. 2006, 52(1): 46-52.

Researcher : Yuen AWC

List of Research Outputs

Lam C.M., Yuen A.W.C., Chik B., Wai A.C. and Fan S.T., Variation in the use of laparoscopic cholecystectomy for acute cholecystitis: a population-based study, Archives of Surgery. 2005, 140(11): 1084-1088.

Researcher : Yuen PW

Project Title:	The identification of proteomic tumor marker of upper aerodigestive tract squamous cell carcinoma
Investigator(s):	Yuen PW, He Q, Chiu J
Department:	Surgery
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2003
Completion Date:	08/2006

Abstract:

To identify the proteomic tumor markers of UADTSCC that are differentially expressed in both UADTSCC primary tumor and sera of patients. These differentially expressed proteins can provide information on the molecular mechanism of carcinogenesis of UADTSCC and may also be used clinically for screening of cancer and monitoring recurrence after treatment.

Project Title:	The identification of proteomic tumor marker of upper aerodigestive tract squamous cell carcinoma
Investigator(s):	Yuen PW, He Q, Chiu J
Department:	Surgery
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	09/2003

Abstract:

N/A

Project Title:	The identification of a panel of methylated gene promoters as tumor markers of nasopharyngeal carcinoma
Investigator(s):	Yuen PW
Department:	Surgery
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003
Completion Date:	10/2005

Abstract:

To identify a panel of methylated genes as tumor marker of nasopharyngeal carcinoma (NPC).

Project Title:	The evaluation of the clinical application of hypermethylated promoter DNA as tumor marker of nasopharyngeal carcinoma
Investigator(s):	Yuen PW
Department:	Surgery
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

N/A

Project Title:	The evaluation of the clinical application of hypermethylated DNA as tumor marker in body fluids for screening of primary and recurrent nasopharyngeal carcinoma
Investigator(s):	Yuen PW, Sham JST, Kwong DLW, Wei WI
Department:	Surgery
Source(s) of Funding:	Michael Kadoorie Cancer Genetics Research Fund
Start Date:	01/2005

Abstract:

To identify genes that are specifically and frequently methylated in NPC; to evaluate the sensitivity and specificity of screening primary and recurrent NPC in body fluids of peripheral blood, nasopharyngeal swab and throat rinsing fluid using methylated DNA as tumor marker.

Project Title:	The evaluation of the clinical application of hypermethylated promoter DNA as tumor marker of nasopharyngeal carcinoma
Investigator(s):	Yuen PW, Kwong DLW
Department:	Surgery
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	01/2005

Abstract:

To identify the genes that are frequently methylated in NPC tumor and can be used as tumor marker in body fluids of blood, nasopharyngeal swab and throat rinsing fluid for the screening of primary NPC and residual NPC after treatment.

Project Title:	The evaluation of therapeutic application of demethylation of oral tongue carcinoma
Investigator(s):	Yuen PW
Department:	Surgery
Source(s) of Funding:	Small Project Funding
Start Date:	09/2005

Abstract:

Background: Methylation of the CG rich promoter region and histone deacethylation of many genes particularly tumor suppressor genes have been found to be common epigenetic abnormalities in many cancers including oral tongue carcinoma. Genes that are silenced due to promoter methylation can be reactivated by demethylating agents. Since gene expression profile is directly related to cellular properties, re-expression of silenced genes will alter the biologic properties of cancer cells. Epigenetic therapy using demethylating agents have been shown to result in re-expression of silenced genes to induce apoptosis, killing of cancer cells, suppression of cell proliferation and modulation of many biologic properties of cancer cells including radiosensitivity and chemosensitivity. Demethylation therapy is a promising new modality of treatment option of cancer either alone or in combination with other treatment modalities. Many demethylating agents are available recently. I have found high frequencies of methylation of many tumor suppressor genes in head and neck carcinoma including oral tongue carcinoma. I have also shown that p15, p16 and E-cadherin methylation are found in aprarently normal oral mucosa of chronic smokers and drinkers. It indicates the presence of cancerization field changes induced by tobacco and alcohol. It therefore worths to evaluate the potential to reverse the methylation in field cancerization process of premailinant stages of carcinogenesis and also treat advanced, recurrent or metastatic head and neck carcinoma with demethylating agents. The therapeutic efficacy of various epigenetic therapeutic agents in reversing epigenetic changes in head and neck carcinoma either alone or in combination with other chemotherapeutic agents are still unknown. In view of the many compounds available for possible clinical trial as monotherapy and the large number of possible regimens in combination with conventional chemotherapy, a pre-clinical evaluation of therapeutic efficacy in cell lines and mice model is therefore necessary to resolve on the best possible regimens for experimental design of subsequent clinical trials. The aim of this study is to evaluate the therapeutic afficacy of various demethylating agents in tongue carcinoma.

List of Research Outputs

Cheung H.W., Ching Y.P., Nicholls J.M., Ling M.T., Wong Y.C., Hui C.M., Cheung A., Tsao G.S.W., Wang Q., Yuen P.W., Lo K.W., Jin D. and Wang X., Epigenetic inactivation of CHFR in nasopharyngeal carcinoma through promoter methylation, Molecular Carcinogenesis. 2005, 43(4): 237-245.

Lam P.K.Y., Ho W.K., Ho A.C., Ng W.M., Yuen P.W. and Wei W.I., Long-term performance of indwelling tracheoesophagel speaking valves in Chinese patients undergoing laryngectomy, Arch Otolaryngol Head Neck Surg. 2005, 131: 954-8.

Li H.M., Man C.W.Y., Jin Y., Deng W., Yip Y.L., Feng H., Cheung Y.C., Lo K.W., Meltzer P.S., Wu Z.G., Kwong Y.L., Yuen P.W. and Tsao G.S.W., Molecular and cytogenetic changes involved in the immortalization of nasopharyngeal epithelial cells by telomerase, International Journal of Cancer. 2006, 119: 1567-1576.

Poon R.T.P., Lee K.W., Yuen P.W., Ling M.T., Wang X., Wong Y.C., Guan X.Y., Man K. and Fan S.T., Id-1 promotes angiogenesis in hepatocellular carcinoma through HIF-1a-mediated VEGF upregulation (Abstract), The 97th Annual Meeting of the American Association of Cancer Research, Washington D.C., U.S.A., 1 - 5 April 2006.

Wei W.I., Yuen P.W., Fan Y.W., Lam L.K. and Wong L.Y., Outcome Analysis of Patients with Craniofacial Resection: Hong Kong Experience, Australia New Zealand Journal of Surgery. New Zealand, Royal Australasian College of Surgeons, 2005, 76: 313-317.

Wong H.L., Wang X., Chang R.C.C., Jin D., Feng H., Wang Q., Lo K.W., Huang D.P., Yuen P.W., Wong Y.C. and Tsao G.S.W., Stable expression of EBERs in immortalized nasopharyngeal epithelial cells confers resistance to apoptotic stress., Molecular Carcinogenesis. 2005, 44: 92-101.

Wong T.S., Kwong D.L., Sham J.S., Wei W.I. and Yuen P.W., Methylation status of Reprimo in head and neck carcinomas, Int J Cancer. 2005, 117: 697.

Yuen P.W., Journal of Plastic, Reconstructive & Aesthetic Surgery, Preservation of lateral thoracic artery to improve vascular supply of distal skin without compromising pedicle length in harvesting pectoralis major myocutaneous flap. Britain, Elsevier, 2006, 59: 1433-1435.

Researcher : Yuen WK

List of Research Outputs

Chim J.C.S., Yuen W.K., Loong F., Hu H.C. and Ooi C.G.C., Primary large B-cell lymphoma of the ampulla of vater, Haematologica. 2006, 91(3): ECR06.

Chok K.S.H., Lau H. and Yuen W.K., Development of outpatient laparoscopic surgery in Hong Kong, Day Surgery Journal of India. 2006, 2: 29-34.

Chok K.S.H., Yuen W.K., Lau H., Lee F.C.W. and Fan S.T., Five-year experience of outpatient laparoscopic cholecystectomy in Hong Kong, Surgical Practice. 2005, 9(4): 143-146.

Lau H., Patil N.G. and Yuen W.K., Day-case endoscopic totally extraperitoneal inguinal hernioplasty versus open Lichtenstein hernioplasty for unilateral primary inguinal hernia in males: a randomized trial, Surgical Endoscopy. 2006, 20(1): 76-81.

Lau H., Lo C.Y., Patil N.G. and Yuen W.K., Early versus delayed-interval laparoscopic cholecystectomy for acute cholecystitis: a metaanalysis, Surgical Endoscopy. 2006, 20(1): 82-87.

Lau H., Patil N.G. and Yuen W.K., Is endoscopic totally extraperitoneal hernioplasty justified for the repair for groin hernia in female patients?, Surgical Endoscopy. 2005, 19(12): 1544-1548.

Lau H. and Yuen W.K., Trauma: a multi-disciplinary sub-specialty (Editorial), Surgical Practice. 2005, 9(4): 115.

Researcher : Zhang J

List of Research Outputs

Zhang Q., Luk J.M.C., Zhang J. and Tian G.Y., Targeting glycyrrhetinic acid to hepatic stellate cells in treating rat liver fibrosis (in chinese), Zhonghua Gan Zang Bing Za Zhi. 2005, 13(9): 664-667.

Researcher : Zhang Q

List of Research Outputs

Luk J.M.C., Zhang Q., Wo J., Leung P.P., Hu M.Y., Lau G. and Fan S.T., Hepatic stellate cell-targeted delivery of 18beta-glycyrrhetinic acid modulates bile duct ligation-induced fibrosis in rat liver, Hepatology. 2005, 42(4): 266A-266A Suppl 1.

Zhang Q., Luk J.M.C., Zhang J. and Tian G.Y., Targeting glycyrrhetinic acid to hepatic stellate cells in treating rat liver fibrosis (in chinese), Zhonghua Gan Zang Bing Za Zhi. 2005, 13(9): 664-667.

Researcher : Zhao Y

List of Research Outputs

Man K., Zhao Y., Xu A., Lo C.M., Lam K.S., Ng K.T., Ho J.W.Y., Sun C.K. and Lee K.W., FTY720 significantly improves small-for-size fatty liver graft survival, American Journal of Transplantation. 2006, 6(3): 467-476.

Man K., Zhao Y., Xu A., Lo C.M., Lam K.S.L., Ng T.P., Ho J.W.Y., Sun K.W., Lee K.W., Li X. and Fan S.T., Fat-derived hormone adiponectin combined with FTY720 significantly improves small-for-size fatty liver graft survival, American Journal of Transplantation. 2006, 6(3): 467-476.

Man K., Su M., Ng T.P., Lo C.M., Zhao Y., Ho J.W.Y., Sun K.W., Lee K.W. and Fan S.T., Rapamycin attenuates liver graft injury in cirrhotic recipient - the significance of down-regulation of Rho-ROCK-VEGF pathway, American Journal of Transplantation. 2006, 6(4): 697-704.

Researcher : Zhu L

List of Research Outputs

Chow L.W.C., Zhu L., Loo T.Y. and Lui E.L.H., Aberrant methylation of cyclooxygenase-2 in breast cancer patients, Biomedicine & Pharmacotherapy. 2005, 59: S264-S267.

Chow L.W.C., Loo T.Y., Wai C.C.Y., Lui E.L.H., Zhu L. and Toi M., Study of COX-2, Ki67 and p53 expression to predict effectiveness of 5-flurouracil, epirubicin and cyclophosphamide with celecoxib treatment in breast cancer patients, Biomedicine & Pharmacotherapy. 2005, 59: S298-S301.

Loo T.Y., Fong J.H.M., Zhu L., Cheung M.N.B. and Chow L.W.C., The value of bone marrow aspirates culture for the detection of bone marrow micrometastasis in breast cancer, Biomedicine & Pharmacotherapy. 2005, 59: S384-S386.

Lui E.L.H., Loo T.Y., Zhu L., Cheung M.N.B. and Chow L.W.C., DNA hypermethylation of TIMP3 gene in invasive breast ductal carcinoma, Biomedicine & Pharmacotherapy. 2005, 59: S363-S365.

Zhu L., Loo T.Y. and Chow L.W.C., Circulating tumor cells in patients with breast cancer: possible predictor of mciro-metastasis in bone marrow but not in sentinel lymph nodes, Biomedicine & Pharmacotherapy. 2005, 59: S355-S358.

Zhu L., Loo T.Y. and Chow L.W.C., Cyclooxygenase-2: possible predictor related to micrometastasis in breast cancer patients (Abstract), Biomedicine & Pharmacotherapy. 2005, 59: S318.

Zhu L., Loo W.T., Cheng C.W. and Chow L.W.C., Possible predictive markers related to micro-metastasis in breast cancer patients, Onoclogy Reports. 2006, 15: 1217-1223.

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