DEPT OF SURGERY - OTORHINOLARYNGOLOGY UN



Researcher : Wei WI

Project Title:Intra-arterial chemoradiation for advanced head and neck cancer
Investigator(s):Wei WI, Sham JST
Department:Surgery
Source(s) of Funding:Other Funding Scheme
Start Date:07/2002
Abstract:
To see if chemotherapy and radiotherapy given can help patients with advanced head and neck cancer.


Project Title:Quantitative analysis of plasma Epstein-Barr-Virus DNA in nasopharyngeal carcinoma after salvage nasopharyngectomy
Investigator(s):Wei WI
Department:Surgery
Source(s) of Funding:Other Funding Scheme
Start Date:09/2002
Abstract:
To study early detection of recurrence after radiotherapy for nasopharyngeal cancer.


Project Title:Modifications of techniques of cochlear implantation
Investigator(s):Wei WI, Au DKK, Ho WK
Department:Surgery
Source(s) of Funding:Other Funding Scheme
Start Date:09/2002
Abstract:
To study the technique and mode of insertion of cochlear implant aiming to improve the efficacy of the implant.


Project Title:Management of snoring and OSA
Investigator(s):Wei WI, Ho WK
Department:Surgery
Source(s) of Funding:Other Funding Scheme
Start Date:09/2002
Abstract:
To find the incidence of snoring and OSA and advance their treatments.


Project Title:VEGF in nasopharyngeal cancer
Investigator(s):Wei WI, Kwong DLW, Poon RTP
Department:Surgery
Source(s) of Funding:Other Funding Scheme
Start Date:03/2003
Abstract:
To carry out early detection of nasopharyngeal cancer before radiotherapy and after treatment.


Project Title:Study the spread of aerosol during tracheostomy or intubation
Investigator(s):Wei WI, Sham JST, Irwin MG
Department:Surgery
Source(s) of Funding:Other Funding Scheme
Start Date:04/2003
Abstract:
To investigate the distance and pattern of aerosol spread during surgical procedures in application to SARS.


Project Title:Head and neck course in China - to teach techniques of contemporary operations and patient care for doctors and nurses working in underdeveloped areas in China. This will benefit those poor patients suffereing from head and neck cancer in China
Investigator(s):Wei WI, Lam LK, Hui Y, Ng WM
Department:Surgery
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:10/2003
Abstract:
To teach head and neck surgeons in China the contemporary methods of managing patients suffering from head and neck cancer and also to introduce the concept of optimal nursing care for these patients.


Project Title:Speech rehabilitation after total laryngectomy - self help and mutual help
Investigator(s):Wei WI, Ho WK
Department:Surgery
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:10/2003
Abstract:
To visit the hospitals and centres in China where total laryngectomy is performed for patients suffering from cancer of the larynx.


Project Title:Cochlear implant for 14 profoundly deaf children in China
Investigator(s):Wei WI, Au DKK, Hui Y
Department:Surgery
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:10/2003
Abstract:
To help Chinese children who are profoundly deaf in China to receive the cochlear implant, so that they will be able to hear, speak and to receive education effectively.


Project Title:Cochlear implant for 14 profoundly deaf Chinese children in China
Investigator(s):Wei WI, Hui Y, Au DKK
Department:Surgery - Otorhinolaryngology Un
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:07/2005
Abstract:
To provide profoundly deaf in China a chance to received cochlear implant so that they can learn to hear and speak, and receive normal mainstream education.


Project Title:Speech rehabilitation after total laryngectomy - self help and mutual help
Investigator(s):Wei WI, Ho LM, Kwok ICL
Department:Surgery - Otorhinolaryngology Un
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:07/2005
Abstract:
To provide coaching to another laryngectomee who has learned to speak again after surgery to teach patients to speak again.


Project Title:Head and neck course in China - to teach techniques of contemporary operations and patient care for doctors and nurses working in relatively underdeveloped areas in China
Investigator(s):Wei WI, Lam LK, Hui Y, Li GKH
Department:Surgery - Otorhinolaryngology Un
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:07/2005
Abstract:
To teach head and neck surgeons in China the contemporary methods of managing patients suffering from head and neck cancer and also to introduce the concept of optimal nursing care for these patients.


Project Title:Bone-anchored hearing aid for the severe deaf patients
Investigator(s):Wei WI, Ho WK, Au DKK
Department:Surgery - Otorhinolaryngology Un
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:07/2007
Abstract:
To improve hearing abilities of certain groups of patients who cannot be helped by conventional hearing aids and to provide hearing rehabilitation to children to enhance their speech and language development.


Project Title:Speech rehabilitation after total laryngectomy - self help and mutual help
Investigator(s):Wei WI, Kwok ICL
Department:Surgery - Otorhinolaryngology Un
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:08/2007
Abstract:
To visit the hospitals and centres in China where total laryngectomy are performed for patients suffering from advanced cancer of the larynx. During the visit, the members will introduce to patients the various methods of speech rehabilitation and to show how patients can help each other during the convalescent period.


Project Title:Head and neck course in China - to introduce techniques of contemporary operations and patient care for doctors and nurses working in relatively underdeveloped areas in China
Investigator(s):Wei WI, Ng WM, Ho WK
Department:Surgery - Otorhinolaryngology Un
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:08/2007
Abstract:
To teach head and neck surgeons in China the contemporary methods of managing patients suffering from head and neck cancer and also to introduce the concept of optimal nursing care for these patients; before, during and after operation.


Project Title:American Academy of Otolaryngology - Head and Neck Surgery 2007 Annual Meeting Nasopharyngeal cancer: early diagnosis, treatment and salvage
Investigator(s):Wei WI
Department:Surgery - Otorhinolaryngology Un
Source(s) of Funding:URC/CRCG - Conference Grants for Teaching Staff
Start Date:09/2007
Abstract:
N/A


Project Title:Three-dimensional evaluation of tumor extension patterns of nasopharyngeal carcinoma
Investigator(s):Wei WI, Wong STS
Department:Surgery - Otorhinolaryngology Un
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:03/2008
Abstract:
Nasopharyngeal cancer is a common disease in our locality. The primary treatment modality is radiation and concurrent chemotherapy. In a small number of patients the tumour unfortunately recurs after this combined mortality of treatment. The surgical salvage is now possible with the maxillary swing approach nasopharyngectomy. We however, are not sure of the exact infiltrative pattern at the primary site of these recurrent nasopharyngeal cancer. The aim of the project is to study the pattern of tumour extension in the nasopharynx; whether it involves cartilage, the prevertebral muscle, and the skull base. It is known that recurrent tumour after radiation is difficult to diagnose and as it may be well located in submusocal region. We have collected over 50 specimens of nasopharyngectomy performed for recurrent nasopharyngeal cancer after chemoradiation. We plan to perform whole specimen section of these specimens so that, we can have a three-dimensional recognition of the pattern of tumour extension. This could greatly aid the planning of surgical savage. Molecular markers such as hypermethylated CpG rich locus can also be examined on these specimen to define exactly where the margin of resection are and whether further resection is possible to achieve a better surgical clearance. Most nasopharyngeal cancer tissues were obtained through biopsies and we have a unique collection of surgical specimen to allow this type of whole specimen section with histological examination as well as with molecular tests to be carried out. This will determine clearly the pattern of tumour extension of nasopharyngeal cancer after chemoradiation.


Project Title:Head and neck course in China - to introduce current surgical techniques and patient care for doctors and nurses working in relatively underdeveloped areas in China
Investigator(s):Wei WI, Ng WM, Ho WK
Department:Surgery - Otorhinolaryngology Un
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:09/2008
Abstract:
We will conduct head and neck surgery teaching course in different cities of China for 3 to 4 days annually. Senior surgeons and nurses from other cities and provinces in China would come and get acquainted with the latest developments in surgical technique and treatment plan. The knowledge they gained will help the poor and sick patients suffering from head and neck cancer in China.




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