THE UNIVERSITY OF HONG KONG
Research and Scholarship 2004

DEPARTMENT OF PHARMACOLOGY



Researcher : Au YKW
List of Research Outputs

Au Y.K.W., Woo W.H.C., Sung L., Yip C.W., Siow Y.L. and O K., Hyperhomocysteinemia Activates Nuclear Factor-kB in Endothelial Cells via Oxidative Stress, Circulation Research. 2004, 94: 28-36.
O K., Sung L., Au Y.K.W., Yip C.W. and Siow Y.L., Homocysteine activates nuclear factor kappa-B in endothelial cells: Role of oxidative stress, The XIIIth International Symposium on Atherosclerosis, 28 September-2 October, Japan. 2003, 2P-0375.


Researcher : Chan MMY
List of Research Outputs

Chan C.C.W., Ng E.H.Y., Chan M.M.Y., Tang F.O.S., Lau E.Y.L., Yeung W.S.B. and Ho P.C., Bioavailability of hCG after intramuscular or subcutaneous injection in obese and non-obese women, Human Reproduction. 2003, 18(11): 2294-2297.


Researcher : Chau JFL
List of Research Outputs

Guo J., Chau J.F.L., Shen X.Z., Cho C.H., Luk J.M.C. and Koo M.W.L., Over-Expression of Inducible Heat Shock Protein 70 in the Gastric Mucosa of Partially Sleep-Deprived Rats, Scandinavian Journal of Gastroenterology. 2004, 39: 510-515.


Researcher : Chen J
List of Research Outputs

Chen J., Ye Z.Q. and Koo M.W.L., Growth inhibition and cell cycle arrest effects of epigallocatechin gallate in the NBT-II bladder tumour cell line, British Journal of Urology International. 2004, 93: 1082-1086.


Researcher : Cheng CL
List of Research Outputs

Cheng C.L., Guo J., Luk J.M.C. and Koo M.W.L., The healing effects of Centella extract and asiaticoside on acetic acid induced gastric ulcers in rats, Life Sciences. 2004, 74: 2237-2249.
Guo J., Cho C.H., Wang W., Shen X., Cheng C.L. and Koo M.W.L., Expression and activities of three inducible enzymes in the healing of gastric ulcers in rats, World Journal of Gastroenterology. 2003, 9(8): 1767-1771.


Researcher : Cheung F
List of Research Outputs

Woo W.H.C., Cheung F., Chan V.W.H., Siow Y.L. and O K., Homocysteine stimulates inducible nitric oxide synthase expression in macrophages: antagonizing effect of ginkgolides and bilobalide, Molecular and Cellular Biochemistry. 2003, 243: 37-47.


Researcher : Cheung TYG
List of Research Outputs

Cheung T.Y.G., Yuen W.H., Kwong Y.L., Au W.Y., Man R.Y.K., Wong W.I. and Kumana C.R., Monitoring blood arsenic in outpatients with acute promyelocytic leukemia receiving oral arsenic trioxide, The 9th Southeast Asian-Western Pacific Regional Meeting of Pharmacologists. 2003, 7, Suppl. 1: 99.


Researcher : Cho CH
Project Title:Delineation of the co-regulatory role of cyclooxygenase-2 and 12-lipoxygenase in colorectal cancer: a causal relationship with ulcerative colitis and cigarette smoking
Investigator(s):Prof. Cho C.H., Dr. Wong B.C.Y., Dr. Yuen S.T.
Department:Pharmacology
Source(s) of Funding:Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:09/2002
Completion Date:08/2004
Abstract:
The project aims at demonstrating the following hypotheses: 1) repeated inflammation may contribute to cancer formation in the colon; 2) COX-2 and 12-LOX could play a co-regulatory role in the pathogenesis of colorectal cancer (CRC); and 3) cigarette smoking could modulate the expression of these enzymes and increase CRC carcinogenesis.


Project Title:Study of cigarette smoking on gastrointestinal cancer development in mice
Investigator(s):Prof. Cho C.H.
Department:Pharmacology
Source(s) of Funding:Block Grant Earmarked for Research
Start Date:11/2002
Completion Date:10/2003
Abstract:
To reveals the possibility of tumor development in the stomach and colon after implantation of respective human cancer cells directly into these organs in nude mice; to advances the understanding concerning the effects of cigarette smoking on tumor growth in the stomach and colon.


Project Title:Studying the ulcerogenic action of dexamethasone and its relationship with PGE2 on ulcer healing in the stomach
Investigator(s):Prof. Cho C.H.
Department:Pharmacology
Source(s) of Funding:Block Grant Earmarked for Research
Start Date:11/2003
Abstract:
To apply the non-ulcerogenic doses of dexamethasone, a potent corticosteroid, to explore its action on ulcer healing and the mechanistic pathway related to prostaglandin E[2] synthesis in a rat ulcer model in the stomach.


Project Title:Delineation of the contributory role of EGF/polyamine/K+ channel in gastric mucosal repair
Investigator(s):Prof. Cho C.H., Dr. Li G.R., Prof. Wang J.Y., Prof. Wong T.M.
Department:Pharmacology
Source(s) of Funding:Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:12/2003
Abstract:
To clarify the integrating roles of EGF and polyamines together with the KV channels and the ca2+cy+ in gastric mucosal repair; to elucidate the mechanism of how cigarette smoke and its ingredien + affect ulcer healing.


Project Title:Delineation of the contributory role of EGF/polyamine/K+ channel in gastric mucosal repair
Investigator(s):Prof. Cho C.H., Dr. Li G.R., Prof. Wang J.Y., Prof. Wong T.M.
Department:Pharmacology
Source(s) of Funding:RGC Projects (Block Grant Funded)
Start Date:12/2003
Abstract:
To clarify the integrating roles of EGF and polyamines together with the KV channels and the ca2+cy+ in gastric mucosal repair; to elucidate the mechanism of how cigarette smoke and its ingredien + affect ulcer healing.


List of Research Outputs

Cho C.H., Shin V.Y., Ye Y. and Liu S.L.E., New actions for nicotine in the gastrointestinal tract, The 9th Southeast Asian-Western Pacific Regional Meeting of Pharmacologists. 2003, 7, Suppl. 1: 40.
Cho C.H., Ko J.K.S. and Koo M.W.L., Perspectives and Clinical Significance of Eicosanoids in the Digestive System, The Eicosanoids. John Wiley & Sons Ltd, 2004, Chapter 36: 407-414.
Guo J., Wang J.Y., Cho C.H. and Koo M.W.L., Differential Effects of Selective or Non-selective Inhibitors of Nitric Oxide Synthase on the Expression and Activity of Cyclooxygenase-2 During Gastric Ulcer Healing, Gastroenterology . 2004, 126, No. 4, Suppl 2: W1326.
Guo J., Cho C.H., Wang W., Shen X., Cheng C.L. and Koo M.W.L., Expression and activities of three inducible enzymes in the healing of gastric ulcers in rats, World Journal of Gastroenterology. 2003, 9(8): 1767-1771.
Guo J., Chau J.F.L., Shen X.Z., Cho C.H., Luk J.M.C. and Koo M.W.L., Over-Expression of Inducible Heat Shock Protein 70 in the Gastric Mucosa of Partially Sleep-Deprived Rats, Scandinavian Journal of Gastroenterology. 2004, 39: 510-515.
Li G., Xia H.H.X., Chen M.H., Peng J., Gu Q., Cui J., Cho C.H., Lam S.K., Lin M.C., Berg D.E., Feng Z., Langenbach R., Kung H. and Wong B.C.Y., Cyclooxygenase-2 Gene Disruption Enhances Gastric Inflammation but Inhibits Gastric Epithelial Proliferation Induced by H. pylori Infection, Gastroenterology. 2004, 126 (4 Suppl 2): W907.
Luo J.C., Shin V.Y., Liu S.L.E., Ye Y., Wu K.K., So H.L., Chang F.Y. and Cho C.H., Dexamethasone delays ulcer healing by inhibition of angiogenesis in rat stomachs, European Journal of Pharmacology. 2004, 485: 275-281.
Luo J.C., Shin V.Y., Liu S.L.E., So H.L., Ye Y., Chang F.Y. and Cho C.H., Non-Ulcerogenic Dose of Dexamethasone Delays Gastric Ulcer Healing in Rats, The Journal of Pharmacology and Experimental Therapeutics . 2003, 307(2): 692-698.
Shang P., Qian A.R., Yang T.H., Jia M., Mei Q.B., Cho C.H., Zhao W.M. and Chen Z.N., Experimental study of anti-tumor effects of polysaccharides from Angelica sinensis , World Journal of Gastroenterology. 2003, 9 (9): 1963-1967.
Shin V.Y., Liu E.S.L., Ye Y.N., Koo M.W.L., Chu K.M. and Cho C.H., A mechanistic study of cigarette smoke and cyclooxygenase-2 on proliferation of gastric cancer cells, Toxicology and Applied Pharmacology. 2004, 195(1): 103-112.
Shin V.Y., Ye Y., Koo M.W.L. and Cho C.H., Activation of extracellular signal-regulated kinase (ERK) and cyclooxygenase-2 (COX-2) is required for nicotine-promoted gastric cancer growth, The 95th American Association for Cancer Research Meeting, March 27-31, Orlando, Florida. 2004, 2524.
Shin V.Y., Ye Y., Koo M.W.L. and Cho C.H., Cyclooxygenase-2 Modulated Cyclin D1, Cyclin-dependent Kinases (Cdks) and Promoted Cell Cycle Progression in Gastric Tumor Growth Stimulated by Nicotine, Gastroenterology. 2004, 126, No. 4, Suppl 2: A409.
Shin V.Y., Liu S.L.E., Ye Y., Koo M.W.L. and Cho C.H., Induction of cyclin D1 and cyclin-dependent kinases in gastric cancer growth induced by cigarette smoke, Program and Proceedings of the AACR-NCI-EORTC International Conference, November 17-21, Hynes Center, Boston, USA. 2003, C91.
Shin V.Y., Ye Y. and Cho C.H., Involvement of extracellular signal-regulated kinase and cyclooxygenase-2 in gastric carcinogenesis promoted by nicotine, The 8th Research Postgraduate Symposium, Faculty of Medicine, The University of Hong Kong, 13 December 2003. 54.
Wu K.K. and Cho C.H., The Pharmacological Actions of Nicotine on the Gastrointestinal Tract, Journal of Pharmacological Sciences. 2004, 94: 348-358.
Ye Y., Liu S.L.E., Shin V.Y. and Cho C.H., Involvement of 5-lipoxygenase in the colonic tumorigenesis promoted by cigarette smoke, Program and Proceedings of the AACR-NCI-EORTC International Conference, November 17-21, Hynes Center, Boston, USA. 2003, B54.
Ye Y., Liu S.L.E., Shin V.Y., Wu K.K., Luo J. and Cho C.H., Nicotine Promoted Colon Cancer Growth via Epidermal Growth Factor Receptor, c-Src, and 5-Lipoxygenase-Mediated Signal Pathway, The Journal of Pharmacology and Experimental Therapeutics. 2004, 308(1): 66-72.
Ye Y., Shin V.Y. and Cho C.H., Nicotine promoted colon cancer growth via EGFR, c-Src and 5-lipoxygenase mediated signal pathway , The 8th Research Postgraduate Symposium, Faculty of Medicine, The University of Hong Kong, 13 December 2003. 59.
Ye Y., Shin V.Y. and Cho C.H., Therapeutic role of dual inhibition of cyclooxygenase-2 and 5-lipoxygenase in the colonic tumorigenesis promoted by cigarette smoke, The 95th American Association for Cancer Research Meeting, March 27-31, Orlando, Florida. 2004, 3862.


Researcher : Guo J
List of Research Outputs

Cheng C.L., Guo J., Luk J.M.C. and Koo M.W.L., The healing effects of Centella extract and asiaticoside on acetic acid induced gastric ulcers in rats, Life Sciences. 2004, 74: 2237-2249.
Guo J., Wang J.Y., Cho C.H. and Koo M.W.L., Differential Effects of Selective or Non-selective Inhibitors of Nitric Oxide Synthase on the Expression and Activity of Cyclooxygenase-2 During Gastric Ulcer Healing, Gastroenterology . 2004, 126, No. 4, Suppl 2: W1326.
Guo J., Cho C.H., Wang W., Shen X., Cheng C.L. and Koo M.W.L., Expression and activities of three inducible enzymes in the healing of gastric ulcers in rats, World Journal of Gastroenterology. 2003, 9(8): 1767-1771.
Guo J., Chau J.F.L., Shen X.Z., Cho C.H., Luk J.M.C. and Koo M.W.L., Over-Expression of Inducible Heat Shock Protein 70 in the Gastric Mucosa of Partially Sleep-Deprived Rats, Scandinavian Journal of Gastroenterology. 2004, 39: 510-515.


Researcher : Ho YW
List of Research Outputs

Ho Y.W., Man R.Y.K. and Lau W.C.S., Effects of ganoderm lucidium (Lingzhi) on proliferation and cytokine production of synovial fibroblasts from rheumatoid arthritis patients, Annals of the Rheumatic Diseases, The EULAR Journal. 2003, 62(suppl I): 409.


Researcher : Keung WYW
List of Research Outputs

Keung W.Y.W. and Man R.Y.K., Non-Genomic Effect of 17b-Estradiol in Rat Mesenteric Arteries is Endothelium-Dependent and Involves the Cyclic AMP Cascade, Journal of the Hong Kong College of Cardiology (Abstracts of the 7th Annual Scientific Meeting ICSM, 6-7 December 2003). 2003, 11, Suppl 1: A19.
Keung W.Y.W. and Man R.Y.K., Non-Genomic Effect of 17b-Estradiol on Vascular Contraction in Rat Mesenteric Arteries, Journal of the Hong Kong College of Cardiology (Abstracts of the 7th Annual Scientific Meeting ICSM, 6-7 December 2003). 2003, 11, Suppl 1: A13.
Keung W.Y.W. and Man R.Y.K., Non-genomic effect of 17b-estradiol in rat arteries is endothelium-dependent and involves the cyclic AMP cascade, The 8th Research Postgraduate Symposium, Faculty of Medicine, The University of Hong Kong, 13 December 2003. 83.
Man R.Y.K., Leung S.W.S., Teoh H., Quan A., Keung W.Y.W. and Lee Y.K.M., Phytoestrogens and Cardiovascular Disorders, Pathophysiology of Cardiovascular Disease. USA, Kluwer Academic Publishers, 2004, 513-524.
Man R.Y.K., Leung S.W.S., Keung W.Y.W. and Teoh H., Vascular actions of the female sex hormone, 17b-estradiol, in coronary blood vessels, The 9th Southeast Asian-Western Pacific Regional Meeting of Pharmacologists. 2003, 7, Suppl. 1: 22.


Researcher : Ko JKS
List of Research Outputs

Cho C.H., Ko J.K.S. and Koo M.W.L., Perspectives and Clinical Significance of Eicosanoids in the Digestive System, The Eicosanoids. John Wiley & Sons Ltd, 2004, Chapter 36: 407-414.


Researcher : Koo MWL
Project Title:Sustained release drug delivery system and green tea on bladder cancer
Investigator(s):Dr. Koo M.W.L., Dr. Chen J.
Department:Pharmacology
Source(s) of Funding:Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:09/2001
Completion Date:02/2004
Abstract:
To examine the efficacy of HPC-MMC preparation on bladder cancer macroscopically and histologically on bladder tissues obtained from rates; to determine the expression of multiple drug resistance (MDR) genes and P-glycoprotein by in situ-hybridization and immunohistochemical studies.


Project Title:Effects of antioxidants and the roles of heat shock protein 32 on cognitive functions in aging
Investigator(s):Dr. Koo M.W.L.
Department:Pharmacology
Source(s) of Funding:Block Grant Earmarked for Research
Start Date:11/2002
Abstract:
To carify the roles of HOs in aging and its involvement in cognitive functions; to elucidate the usefulness of antioxidants in delaying cognitive function loss during aging.


Project Title:Alleviating effect of Bu-zhong-yi-qi-tang on chemotherapy-induced bone marrow suppression in mice
Investigator(s):Dr. Koo M.W.L.
Department:Pharmacology
Source(s) of Funding:Block Grant Earmarked for Research
Start Date:11/2003
Abstract:
To investigate the mechanisms of action from herbs particularly on bone marrow recovery and CSFs production.


List of Research Outputs

Chan G.C.F., Lam T.W., Chan S., Koo M.W.L., Law H.K.W. and Lau Y.L., Ganoderma Lucidum (Lingzhi, Reishi) Mycelium Extract Enhanced Leukemic Cells Proliferation but Its Spore Extract Suppressed Leukemic Cells Growth In Vitro, Blood - Journal of the American Society of Hematology (45th Annual Meeting Program and Abstracts), California, USA, 6-9 December 2003.
Chen J., Ye Z.Q. and Koo M.W.L., Growth inhibition and cell cycle arrest effects of epigallocatechin gallate in the NBT-II bladder tumour cell line, British Journal of Urology International. 2004, 93: 1082-1086.
Cheng C.L., Guo J., Luk J.M.C. and Koo M.W.L., The healing effects of Centella extract and asiaticoside on acetic acid induced gastric ulcers in rats, Life Sciences. 2004, 74: 2237-2249.
Cho C.H., Ko J.K.S. and Koo M.W.L., Perspectives and Clinical Significance of Eicosanoids in the Digestive System, The Eicosanoids. John Wiley & Sons Ltd, 2004, Chapter 36: 407-414.
Guo J., Wang J.Y., Cho C.H. and Koo M.W.L., Differential Effects of Selective or Non-selective Inhibitors of Nitric Oxide Synthase on the Expression and Activity of Cyclooxygenase-2 During Gastric Ulcer Healing, Gastroenterology . 2004, 126, No. 4, Suppl 2: W1326.
Guo J., Cho C.H., Wang W., Shen X., Cheng C.L. and Koo M.W.L., Expression and activities of three inducible enzymes in the healing of gastric ulcers in rats, World Journal of Gastroenterology. 2003, 9(8): 1767-1771.
Guo J., Chau J.F.L., Shen X.Z., Cho C.H., Luk J.M.C. and Koo M.W.L., Over-Expression of Inducible Heat Shock Protein 70 in the Gastric Mucosa of Partially Sleep-Deprived Rats, Scandinavian Journal of Gastroenterology. 2004, 39: 510-515.
Shin V.Y., Ye Y., Koo M.W.L. and Cho C.H., Activation of extracellular signal-regulated kinase (ERK) and cyclooxygenase-2 (COX-2) is required for nicotine-promoted gastric cancer growth, The 95th American Association for Cancer Research Meeting, March 27-31, Orlando, Florida. 2004, 2524.
Shin V.Y., Ye Y., Koo M.W.L. and Cho C.H., Cyclooxygenase-2 Modulated Cyclin D1, Cyclin-dependent Kinases (Cdks) and Promoted Cell Cycle Progression in Gastric Tumor Growth Stimulated by Nicotine, Gastroenterology. 2004, 126, No. 4, Suppl 2: A409.
Shin V.Y., Liu S.L.E., Ye Y., Koo M.W.L. and Cho C.H., Induction of cyclin D1 and cyclin-dependent kinases in gastric cancer growth induced by cigarette smoke, Program and Proceedings of the AACR-NCI-EORTC International Conference, November 17-21, Hynes Center, Boston, USA. 2003, C91.


Researcher : Lee YKM
List of Research Outputs

Lee Y.K.M. and Man R.Y.K., The phytoestrogen genistein enhances endothelium-independent relaxation in the porcine coronary artery, European Journal of Pharmacology. 2003, 481: 227-232.
Man R.Y.K., Leung S.W.S., Teoh H., Quan A., Keung W.Y.W. and Lee Y.K.M., Phytoestrogens and Cardiovascular Disorders, Pathophysiology of Cardiovascular Disease. USA, Kluwer Academic Publishers, 2004, 513-524.


Researcher : Leung GPH
Project Title:Adenosine: signal transduction pathways and role of nucleoside transporter re-uptake in coronary artery
Investigator(s):Dr. Leung G.P.H., Prof. Man R.Y.K.
Department:Pharmacology
Source(s) of Funding:Block Grant Earmarked for Research
Start Date:08/2004
Abstract:
To identify the signal transduction pathways of the adenosine-induced hyperpolarization in the coronary arterial smooth muscle cells and endothelial cells. We hypothesize that the adensoine-induced hyperpolarization in vascular smooth muscle cells and endothelial cells is mediated via cAMP-independent pathways and involves more than one K+ channels; to identify the mechanism of regulation of extracellular adenosine level in the coronary arterial smooth muscle cells and endothelial cells.




Researcher : Leung SWS
List of Research Outputs

Man R.Y.K., Leung S.W.S., Teoh H., Quan A., Keung W.Y.W. and Lee Y.K.M., Phytoestrogens and Cardiovascular Disorders, Pathophysiology of Cardiovascular Disease. USA, Kluwer Academic Publishers, 2004, 513-524.
Man R.Y.K., Leung S.W.S., Keung W.Y.W. and Teoh H., Vascular actions of the female sex hormone, 17b-estradiol, in coronary blood vessels, The 9th Southeast Asian-Western Pacific Regional Meeting of Pharmacologists. 2003, 7, Suppl. 1: 22.
Quan A., Leung S.W.S., Lao T.T.H. and Man R.Y.K., 5-Hydroxytryptamine and Thromboxane A2 as Physiologic Mediators of Human Umbilical Artery Closure, Journal of the Society for Gynecology Investigation. 2003, 10(8): 490-495.
Xu Y.C., Leung S.W.S. and Man R.Y.K., Kaempferol: a Flavonoid from Traditional Chinese Medicine, Potentiates Endothelium-Dependent and Independent Relaxation , Journal of the Hong Kong College of Cardiology (Abstracts of the 7th Annual Scientific Meeting ICSM, 6-7 December 2003). 2003, 11, Suppl 1: A11.


Researcher : Liu SLE
List of Research Outputs

Cho C.H., Shin V.Y., Ye Y. and Liu S.L.E., New actions for nicotine in the gastrointestinal tract, The 9th Southeast Asian-Western Pacific Regional Meeting of Pharmacologists. 2003, 7, Suppl. 1: 40.
Luo J.C., Shin V.Y., Liu S.L.E., Ye Y., Wu K.K., So H.L., Chang F.Y. and Cho C.H., Dexamethasone delays ulcer healing by inhibition of angiogenesis in rat stomachs, European Journal of Pharmacology. 2004, 485: 275-281.
Luo J.C., Shin V.Y., Liu S.L.E., So H.L., Ye Y., Chang F.Y. and Cho C.H., Non-Ulcerogenic Dose of Dexamethasone Delays Gastric Ulcer Healing in Rats, The Journal of Pharmacology and Experimental Therapeutics . 2003, 307(2): 692-698.
Shin V.Y., Liu S.L.E., Ye Y., Koo M.W.L. and Cho C.H., Induction of cyclin D1 and cyclin-dependent kinases in gastric cancer growth induced by cigarette smoke, Program and Proceedings of the AACR-NCI-EORTC International Conference, November 17-21, Hynes Center, Boston, USA. 2003, C91.
Ye Y., Liu S.L.E., Shin V.Y. and Cho C.H., Involvement of 5-lipoxygenase in the colonic tumorigenesis promoted by cigarette smoke, Program and Proceedings of the AACR-NCI-EORTC International Conference, November 17-21, Hynes Center, Boston, USA. 2003, B54.
Ye Y., Liu S.L.E., Shin V.Y., Wu K.K., Luo J. and Cho C.H., Nicotine Promoted Colon Cancer Growth via Epidermal Growth Factor Receptor, c-Src, and 5-Lipoxygenase-Mediated Signal Pathway, The Journal of Pharmacology and Experimental Therapeutics. 2004, 308(1): 66-72.


Researcher : Luo J
List of Research Outputs

Ye Y., Liu S.L.E., Shin V.Y., Wu K.K., Luo J. and Cho C.H., Nicotine Promoted Colon Cancer Growth via Epidermal Growth Factor Receptor, c-Src, and 5-Lipoxygenase-Mediated Signal Pathway, The Journal of Pharmacology and Experimental Therapeutics. 2004, 308(1): 66-72.


Researcher : Man RYK
Project Title:Effect of cholestin on cholesterol metabolism in hepatic cells
Investigator(s):Prof. Man R.Y.K., Dr. O K.
Department:Pharmacology
Source(s) of Funding:Pharmanex
Start Date:04/2000
Abstract:
To evaluate the effect of cholestin on cholesterol metabolism in human hepatoma cells (HepG2) and to compare its effect with known lipid-lowering agents i.e. statins; to elucidate the biochemical mechanisms of cholestin on lipid metabolism.


Project Title:Defining the bioactive components of Shenmai injection and their mechanisms of action
Investigator(s):Prof. Man R.Y.K., Mr. Li W.D., Dr. O K., Dr. Siow Y.L., Prof. Zhu D.Y.
Department:Pharmacology
Source(s) of Funding:Innovation and Technology Fund, Innovation and Technology Commission of Hong Kong Government
Start Date:05/2002
Abstract:
To obtain a definitive chemical fingerprint of Shen Mai injection; to isolate, identify, and associate the major bioactive components and their structures to measureable biological activities deemed beneficial to cardiovascular disease.


Project Title:The haemodynamic effects of magnesium tanshinoate B, a bioactive component of danshen, in anaesthetized rats
Investigator(s):Prof. Man R.Y.K.
Department:Pharmacology
Source(s) of Funding:Block Grant Earmarked for Research
Start Date:11/2002
Completion Date:10/2004
Abstract:
To investigate the cardiovascular effects of MTB70 in an in vivo anaesthetized rat model, the possible mechanisms underlying the cardiovascular actions of MTB70 will be examined.


Project Title:Modulatory effects of 17b-estradiol on the vascular responses of rat isolated mesenteric and pulmonary arteries
Investigator(s):Prof. Man R.Y.K.
Department:Pharmacology
Source(s) of Funding:Block Grant Earmarked for Research
Start Date:11/2003
Abstract:
To study the acute vascular effects of 17b-estradiol in male as well as female rats. In addition, the modulatory actions of long-term treatment of 17b-estradiol on arterial relaxation will be examined in ovariectomized or sham-operated rats. The possible signal transduction pathway underlying the vascular effects of 17b-estradiol will also be investigated.


List of Research Outputs

Cheung T.Y.G., Yuen W.H., Kwong Y.L., Au W.Y., Man R.Y.K., Wong W.I. and Kumana C.R., Monitoring blood arsenic in outpatients with acute promyelocytic leukemia receiving oral arsenic trioxide, The 9th Southeast Asian-Western Pacific Regional Meeting of Pharmacologists. 2003, 7, Suppl. 1: 99.
Ho Y.W., Man R.Y.K. and Lau W.C.S., Effects of ganoderm lucidium (Lingzhi) on proliferation and cytokine production of synovial fibroblasts from rheumatoid arthritis patients, Annals of the Rheumatic Diseases, The EULAR Journal. 2003, 62(suppl I): 409.
Keung W.Y.W. and Man R.Y.K., Non-Genomic Effect of 17b-Estradiol in Rat Mesenteric Arteries is Endothelium-Dependent and Involves the Cyclic AMP Cascade, Journal of the Hong Kong College of Cardiology (Abstracts of the 7th Annual Scientific Meeting ICSM, 6-7 December 2003). 2003, 11, Suppl 1: A19.
Keung W.Y.W. and Man R.Y.K., Non-Genomic Effect of 17b-Estradiol on Vascular Contraction in Rat Mesenteric Arteries, Journal of the Hong Kong College of Cardiology (Abstracts of the 7th Annual Scientific Meeting ICSM, 6-7 December 2003). 2003, 11, Suppl 1: A13.
Keung W.Y.W. and Man R.Y.K., Non-genomic effect of 17b-estradiol in rat arteries is endothelium-dependent and involves the cyclic AMP cascade, The 8th Research Postgraduate Symposium, Faculty of Medicine, The University of Hong Kong, 13 December 2003. 83.
Lee Y.K.M. and Man R.Y.K., The phytoestrogen genistein enhances endothelium-independent relaxation in the porcine coronary artery, European Journal of Pharmacology. 2003, 481: 227-232.
Man R.Y.K., Leung S.W.S., Teoh H., Quan A., Keung W.Y.W. and Lee Y.K.M., Phytoestrogens and Cardiovascular Disorders, Pathophysiology of Cardiovascular Disease. USA, Kluwer Academic Publishers, 2004, 513-524.
Man R.Y.K., Leung S.W.S., Keung W.Y.W. and Teoh H., Vascular actions of the female sex hormone, 17b-estradiol, in coronary blood vessels, The 9th Southeast Asian-Western Pacific Regional Meeting of Pharmacologists. 2003, 7, Suppl. 1: 22.
Quan A., Leung S.W.S., Lao T.T.H. and Man R.Y.K., 5-Hydroxytryptamine and Thromboxane A2 as Physiologic Mediators of Human Umbilical Artery Closure, Journal of the Society for Gynecology Investigation. 2003, 10(8): 490-495.
Xu Y.C., Leung S.W.S. and Man R.Y.K., Kaempferol: a Flavonoid from Traditional Chinese Medicine, Potentiates Endothelium-Dependent and Independent Relaxation , Journal of the Hong Kong College of Cardiology (Abstracts of the 7th Annual Scientific Meeting ICSM, 6-7 December 2003). 2003, 11, Suppl 1: A11.
Yeung K.Y. and Man R.Y.K., Puerarin, an isoflavonoid derived from radix puerariae, potentiates endothelium-independent vasorelaxation via cAMP-dependent second messenger pathway in porcine coronary artery, The 9th Southeast Asian-Western Pacific Regional Meeting of Pharmacologists. 2003, 7, Suppl. 1: 90.


Researcher : O K
Project Title:Mechanisms of enhanced monocyte binding to vascular endothelium in hyperhomocysteinemia
Investigator(s):Dr. O K.
Department:Pharmacology
Source(s) of Funding:Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:09/2002
Completion Date:08/2005
Abstract:
The project aims to investigate the effect of elevated blood homocysteine (Hcy) levels on monocyte binding to aortic endothelium in dietary-induced hyperhomocysteinemic rats as well as the underlying mechanisms. Specifically, efforts will be made to investigate the mechanisms of MCP-1 expression in endothelium and CCR2 expression in peripheral blood moncytes.


List of Research Outputs

Au Y.K.W., Woo W.H.C., Sung L., Yip C.W., Siow Y.L. and O K., Hyperhomocysteinemia Activates Nuclear Factor-kB in Endothelial Cells via Oxidative Stress, Circulation Research. 2004, 94: 28-36.
O K., Sung L., Au Y.K.W., Yip C.W. and Siow Y.L., Homocysteine activates nuclear factor kappa-B in endothelial cells: Role of oxidative stress, The XIIIth International Symposium on Atherosclerosis, 28 September-2 October, Japan. 2003, 2P-0375.
Woo W.H.C., Cheung F., Chan V.W.H., Siow Y.L. and O K., Homocysteine stimulates inducible nitric oxide synthase expression in macrophages: antagonizing effect of ginkgolides and bilobalide, Molecular and Cellular Biochemistry. 2003, 243: 37-47.
Woo W.H.C., Siow Y.L. and O K., Hyperhomocysteinemia stimulates cholesterol biosynthesis in liver, The XIIIth International Symposium on Atherosclerosis, 28 September-2 October, Japan. 2003, 2P-0376.


Researcher : Quan A
List of Research Outputs

Quan A., Leung S.W.S., Lao T.T.H. and Man R.Y.K., 5-Hydroxytryptamine and Thromboxane A2 as Physiologic Mediators of Human Umbilical Artery Closure, Journal of the Society for Gynecology Investigation. 2003, 10(8): 490-495.


Researcher : Shen X
List of Research Outputs

Guo J., Cho C.H., Wang W., Shen X., Cheng C.L. and Koo M.W.L., Expression and activities of three inducible enzymes in the healing of gastric ulcers in rats, World Journal of Gastroenterology. 2003, 9(8): 1767-1771.


Researcher : Shin VY
List of Research Outputs

Cho C.H., Shin V.Y., Ye Y. and Liu S.L.E., New actions for nicotine in the gastrointestinal tract, The 9th Southeast Asian-Western Pacific Regional Meeting of Pharmacologists. 2003, 7, Suppl. 1: 40.
Luo J.C., Shin V.Y., Liu S.L.E., Ye Y., Wu K.K., So H.L., Chang F.Y. and Cho C.H., Dexamethasone delays ulcer healing by inhibition of angiogenesis in rat stomachs, European Journal of Pharmacology. 2004, 485: 275-281.
Luo J.C., Shin V.Y., Liu S.L.E., So H.L., Ye Y., Chang F.Y. and Cho C.H., Non-Ulcerogenic Dose of Dexamethasone Delays Gastric Ulcer Healing in Rats, The Journal of Pharmacology and Experimental Therapeutics . 2003, 307(2): 692-698.
Shin V.Y., Ye Y., Koo M.W.L. and Cho C.H., Activation of extracellular signal-regulated kinase (ERK) and cyclooxygenase-2 (COX-2) is required for nicotine-promoted gastric cancer growth, The 95th American Association for Cancer Research Meeting, March 27-31, Orlando, Florida. 2004, 2524.
Shin V.Y., Ye Y., Koo M.W.L. and Cho C.H., Cyclooxygenase-2 Modulated Cyclin D1, Cyclin-dependent Kinases (Cdks) and Promoted Cell Cycle Progression in Gastric Tumor Growth Stimulated by Nicotine, Gastroenterology. 2004, 126, No. 4, Suppl 2: A409.
Shin V.Y., Liu S.L.E., Ye Y., Koo M.W.L. and Cho C.H., Induction of cyclin D1 and cyclin-dependent kinases in gastric cancer growth induced by cigarette smoke, Program and Proceedings of the AACR-NCI-EORTC International Conference, November 17-21, Hynes Center, Boston, USA. 2003, C91.
Shin V.Y., Ye Y. and Cho C.H., Involvement of extracellular signal-regulated kinase and cyclooxygenase-2 in gastric carcinogenesis promoted by nicotine, The 8th Research Postgraduate Symposium, Faculty of Medicine, The University of Hong Kong, 13 December 2003. 54.
Ye Y., Liu S.L.E., Shin V.Y. and Cho C.H., Involvement of 5-lipoxygenase in the colonic tumorigenesis promoted by cigarette smoke, Program and Proceedings of the AACR-NCI-EORTC International Conference, November 17-21, Hynes Center, Boston, USA. 2003, B54.
Ye Y., Liu S.L.E., Shin V.Y., Wu K.K., Luo J. and Cho C.H., Nicotine Promoted Colon Cancer Growth via Epidermal Growth Factor Receptor, c-Src, and 5-Lipoxygenase-Mediated Signal Pathway, The Journal of Pharmacology and Experimental Therapeutics. 2004, 308(1): 66-72.
Ye Y., Shin V.Y. and Cho C.H., Nicotine promoted colon cancer growth via EGFR, c-Src and 5-lipoxygenase mediated signal pathway , The 8th Research Postgraduate Symposium, Faculty of Medicine, The University of Hong Kong, 13 December 2003. 59.
Ye Y., Shin V.Y. and Cho C.H., Therapeutic role of dual inhibition of cyclooxygenase-2 and 5-lipoxygenase in the colonic tumorigenesis promoted by cigarette smoke, The 95th American Association for Cancer Research Meeting, March 27-31, Orlando, Florida. 2004, 3862.


Researcher : Siow YL
List of Research Outputs

Au Y.K.W., Woo W.H.C., Sung L., Yip C.W., Siow Y.L. and O K., Hyperhomocysteinemia Activates Nuclear Factor-kB in Endothelial Cells via Oxidative Stress, Circulation Research. 2004, 94: 28-36.
O K., Sung L., Au Y.K.W., Yip C.W. and Siow Y.L., Homocysteine activates nuclear factor kappa-B in endothelial cells: Role of oxidative stress, The XIIIth International Symposium on Atherosclerosis, 28 September-2 October, Japan. 2003, 2P-0375.
Woo W.H.C., Cheung F., Chan V.W.H., Siow Y.L. and O K., Homocysteine stimulates inducible nitric oxide synthase expression in macrophages: antagonizing effect of ginkgolides and bilobalide, Molecular and Cellular Biochemistry. 2003, 243: 37-47.
Woo W.H.C., Siow Y.L. and O K., Hyperhomocysteinemia stimulates cholesterol biosynthesis in liver, The XIIIth International Symposium on Atherosclerosis, 28 September-2 October, Japan. 2003, 2P-0376.


Researcher : So HL
List of Research Outputs

Luo J.C., Shin V.Y., Liu S.L.E., Ye Y., Wu K.K., So H.L., Chang F.Y. and Cho C.H., Dexamethasone delays ulcer healing by inhibition of angiogenesis in rat stomachs, European Journal of Pharmacology. 2004, 485: 275-281.
Luo J.C., Shin V.Y., Liu S.L.E., So H.L., Ye Y., Chang F.Y. and Cho C.H., Non-Ulcerogenic Dose of Dexamethasone Delays Gastric Ulcer Healing in Rats, The Journal of Pharmacology and Experimental Therapeutics . 2003, 307(2): 692-698.


Researcher : Sung L
List of Research Outputs

Au Y.K.W., Woo W.H.C., Sung L., Yip C.W., Siow Y.L. and O K., Hyperhomocysteinemia Activates Nuclear Factor-kB in Endothelial Cells via Oxidative Stress, Circulation Research. 2004, 94: 28-36.
O K., Sung L., Au Y.K.W., Yip C.W. and Siow Y.L., Homocysteine activates nuclear factor kappa-B in endothelial cells: Role of oxidative stress, The XIIIth International Symposium on Atherosclerosis, 28 September-2 October, Japan. 2003, 2P-0375.


Researcher : Tom WM
Project Title:Antioxidants in the prevention of hepatocellular damage
Investigator(s):Dr. Tom W.M.
Department:Pharmacology
Source(s) of Funding:Block Grant Earmarked for Research
Start Date:07/1998
Abstract:
To investigate the underlying mechanisms of cytokine-induced cytotoxicity in human transformed hepatoma cells.




Researcher : Vanhoutte PMGR
Project Title:Endothelial dysfunction in diabetes: role of endothelium-derived contracting factor
Investigator(s):Prof. Vanhoutte P.M.G.
Department:Pharmacology
Source(s) of Funding:Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:08/2003
Abstract:
To examine five hypotheses: a) the lack of NO favors endothelium-dependent contractions: b) the endothelium of diabetic arteries releases more vasoconstrictor breakdown products of arachidonic acid: c) endothelium-dependent contractions are due to a diffusible factor (EDCF); d) oxygen-free radicals play a key role in EDCF-mediated responses: and e) high glucose mimicks the impact of diabetes on endothelial function. These studies should yield a better understanding of the mechanisms(s) underlying diabetic endothelial dysfunction, and hence help to improve the prevention and/or therapy of one of the most feared complications of the disease.


Project Title:Endothelial dysfunction in diabetes: role of endothelium-derived contracting factor
Investigator(s):Prof. Vanhoutte P.M.G.
Department:Pharmacology
Source(s) of Funding:RGC Projects (Block Grant Funded)
Start Date:08/2003
Abstract:
To examine five hypotheses: a) the lack of NO favors endothelium-dependent contractions: b) the endothelium of diabetic arteries releases more vasoconstrictor breakdown products of arachidonic acid: c) endothelium-dependent contractions are due to a diffusible factor (EDCF); d) oxygen-free radicals play a key role in EDCF-mediated responses: and e) high glucose mimicks the impact of diabetes on endothelial function. These studies should yield a better understanding of the mechanisms(s) underlying diabetic endothelial dysfunction, and hence help to improve the prevention and/or therapy of one of the most feared complications of the disease.


Project Title:EDCF in spontaneous hypertension
Investigator(s):Prof. Vanhoutte P.M.G.
Department:Pharmacology
Source(s) of Funding:Block Grant Earmarked for Research
Start Date:11/2003
Abstract:
To explore the exact mechanism(s) underlying, and the importance of, endothelium-dependent contractions in large and small arteries of the spontaneously hypertensive rat, and to study blood vessels of the mouse in order to be able to use genetically modified animals.


List of Research Outputs

Ceuninck F.D., Allain F., Caliez A., Spik G. and Vanhoutte P.M.G.R., High Binding Capacity of Cyclophilin B to Chondrocyte Heparan Sulfate Proteoglycans and Its Release From the Cell Surface by Matrix Metalloproteinases, American College of Rheumatology. 2003, 48, No. 8: 2197-2206.
Félétou M. and Vanhoutte P.M.G.R., EDHF: new therapeutic targets?, Pharmacological Research. 2004, 49: 565-580.
Gardener M.J., Edwards G., Félétou M., Vanhoutte P.M.G.R. and Weston A.H., Effect of HEPES on EDHF responses in porcine coronary and rat mesenteric arteries, EDHF 2002. 2003, 239-247.
Kennedy S., Fournet-Bourguignon M.-.P., Breugnot C., Castedo-Delrieu M., Lesage L., Reure H., Briant C., Leonce S., Vilaine J.-.P. and Vanhoutte P.M.G.R., Cells Derived from Regenerated Endothelium of the Porcine Coronary Artery Contain More Oxidized Forms of Apolipoprotein-B-100 without a Modification in the Uptake of Oxidized LDL, Journal of Vascular Research. 2003, 40: 389-398.
O'Rourke S.T., Hammad H., Delagrange P., Scalbert E. and Vanhoutte P.M.G.R., Melatonin inhibits nitrate tolerance in isolated coronary arteries , British Journal of Pharmacology. 2003, 139: 1326-1332.
Shibano T. and Vanhoutte P.M.G.R., Low molecular weight G-proteins of rho-family mediate relaxations to bradykinin in porcine coronary arteries, Acta Pharmacologica Sinica. 2003, 24(11): 1070-1076.
Vanhoutte P.M.G.R., Endothelial dysfunction and coronary artery disease, Endothelial Dysfunction and Cardiovascular Disease Recent Insights and New Perspectives, Rome (Italy), June 4-5, 2004. 37-39.
Vanhoutte P.M.G.R., Endothelial dysfunction in cardiovascular disease, The 9th Southeast Asian-Western Pacific Regional Meeting of Pharmacologists, 19-23 August, Korea. 2003, 7, Suppl. 1: 3.
Vanhoutte P.M.G.R., Endothelial function and dysfunction, Heart and Metabolism. 2004, 22: 5-10.
Vanhoutte P.M.G.R., Endothelial function: from health to heart failure, Journal of the Hong Kong College of Cardiology (Abstracts of the 7th Annual Scientific Meeting ICSM, 6-7 December 2003) . 2003, 11, Suppl 1: A1.
Vanhoutte P.M.G.R., Endothelium-dependent hyperpolarizations: the history, Pharmacological Research. 2004, 49: 503-508.
Vanhoutte P.M.G.R., Endothelium-derived vasoactive factors: from NO to EDHF , The 3rd International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide, 24-28 May 2004, Nara, Japan. 2004, 11.
Vanhoutte P.M.G.R., Hormonal control of endothelial function revisited, The 9th Southeast Asian-Western Pacific Regional Meeting of Pharmacologists. 2003, 7, Suppl. 1: 21.
Villeneuve N., Miao C.Y., Brunel-Jacquemin C., Petit C., Gransagne D., Briant C., Vilaine J.-.P. and Vanhoutte P.M.G.R., Chronic mild hyperhomocysteinemia induces aortic endothelial dysfunction but no elevation of arterial pressure in rats, The 3rd International Conference on the Biology, Chemistry and Therapeutic Applications of Nitric Oxide, 24-28 May 2004, Nara, Japan. 2004, 173.
Yang D., Gluais P., Zhang J.N., Vanhoutte P.M.G.R. and Félétou M., Endothelium-dependent contractions to acetylcholine, ATP and the calcium ionophore A 23187 in aortas from spontaneously hypertensive and normotensive rats, Fundamental & Clinical Pharmacology. 2004, 18: 321-326.
Yang D., Gluais P., Zhang J.N., Vanhoutte P.M.G.R. and Feletou M., Nitric Oxide and Inactivation of the Endothelium-Dependent Contracting Factor Released by Acetylcholine in Spontaneously Hypertensive Rat, Journal of Cardiovascular Pharmacology. 2004, 43, No. 6: 815-820.


Researcher : Wang W
List of Research Outputs

Guo J., Cho C.H., Wang W., Shen X., Cheng C.L. and Koo M.W.L., Expression and activities of three inducible enzymes in the healing of gastric ulcers in rats, World Journal of Gastroenterology. 2003, 9(8): 1767-1771.


Researcher : Wong WI
List of Research Outputs

Cheung T.Y.G., Yuen W.H., Kwong Y.L., Au W.Y., Man R.Y.K., Wong W.I. and Kumana C.R., Monitoring blood arsenic in outpatients with acute promyelocytic leukemia receiving oral arsenic trioxide, The 9th Southeast Asian-Western Pacific Regional Meeting of Pharmacologists. 2003, 7, Suppl. 1: 99.


Researcher : Woo WHC
List of Research Outputs

Au Y.K.W., Woo W.H.C., Sung L., Yip C.W., Siow Y.L. and O K., Hyperhomocysteinemia Activates Nuclear Factor-kB in Endothelial Cells via Oxidative Stress, Circulation Research. 2004, 94: 28-36.
Woo W.H.C., Cheung F., Chan V.W.H., Siow Y.L. and O K., Homocysteine stimulates inducible nitric oxide synthase expression in macrophages: antagonizing effect of ginkgolides and bilobalide, Molecular and Cellular Biochemistry. 2003, 243: 37-47.
Woo W.H.C., Siow Y.L. and O K., Hyperhomocysteinemia stimulates cholesterol biosynthesis in liver, The XIIIth International Symposium on Atherosclerosis, 28 September-2 October, Japan. 2003, 2P-0376.


Researcher : Wu KK
List of Research Outputs

Luo J.C., Shin V.Y., Liu S.L.E., Ye Y., Wu K.K., So H.L., Chang F.Y. and Cho C.H., Dexamethasone delays ulcer healing by inhibition of angiogenesis in rat stomachs, European Journal of Pharmacology. 2004, 485: 275-281.
Wu K.K. and Cho C.H., The Pharmacological Actions of Nicotine on the Gastrointestinal Tract, Journal of Pharmacological Sciences. 2004, 94: 348-358.
Ye Y., Liu S.L.E., Shin V.Y., Wu K.K., Luo J. and Cho C.H., Nicotine Promoted Colon Cancer Growth via Epidermal Growth Factor Receptor, c-Src, and 5-Lipoxygenase-Mediated Signal Pathway, The Journal of Pharmacology and Experimental Therapeutics. 2004, 308(1): 66-72.


Researcher : Xu YC
List of Research Outputs

Xu Y.C., Leung S.W.S. and Man R.Y.K., Kaempferol: a Flavonoid from Traditional Chinese Medicine, Potentiates Endothelium-Dependent and Independent Relaxation , Journal of the Hong Kong College of Cardiology (Abstracts of the 7th Annual Scientific Meeting ICSM, 6-7 December 2003). 2003, 11, Suppl 1: A11.


Researcher : Ye Y
List of Research Outputs

Cho C.H., Shin V.Y., Ye Y. and Liu S.L.E., New actions for nicotine in the gastrointestinal tract, The 9th Southeast Asian-Western Pacific Regional Meeting of Pharmacologists. 2003, 7, Suppl. 1: 40.
Luo J.C., Shin V.Y., Liu S.L.E., Ye Y., Wu K.K., So H.L., Chang F.Y. and Cho C.H., Dexamethasone delays ulcer healing by inhibition of angiogenesis in rat stomachs, European Journal of Pharmacology. 2004, 485: 275-281.
Luo J.C., Shin V.Y., Liu S.L.E., So H.L., Ye Y., Chang F.Y. and Cho C.H., Non-Ulcerogenic Dose of Dexamethasone Delays Gastric Ulcer Healing in Rats, The Journal of Pharmacology and Experimental Therapeutics . 2003, 307(2): 692-698.
Shin V.Y., Ye Y., Koo M.W.L. and Cho C.H., Activation of extracellular signal-regulated kinase (ERK) and cyclooxygenase-2 (COX-2) is required for nicotine-promoted gastric cancer growth, The 95th American Association for Cancer Research Meeting, March 27-31, Orlando, Florida. 2004, 2524.
Shin V.Y., Ye Y., Koo M.W.L. and Cho C.H., Cyclooxygenase-2 Modulated Cyclin D1, Cyclin-dependent Kinases (Cdks) and Promoted Cell Cycle Progression in Gastric Tumor Growth Stimulated by Nicotine, Gastroenterology. 2004, 126, No. 4, Suppl 2: A409.
Shin V.Y., Liu S.L.E., Ye Y., Koo M.W.L. and Cho C.H., Induction of cyclin D1 and cyclin-dependent kinases in gastric cancer growth induced by cigarette smoke, Program and Proceedings of the AACR-NCI-EORTC International Conference, November 17-21, Hynes Center, Boston, USA. 2003, C91.
Shin V.Y., Ye Y. and Cho C.H., Involvement of extracellular signal-regulated kinase and cyclooxygenase-2 in gastric carcinogenesis promoted by nicotine, The 8th Research Postgraduate Symposium, Faculty of Medicine, The University of Hong Kong, 13 December 2003. 54.
Ye Y., Liu S.L.E., Shin V.Y. and Cho C.H., Involvement of 5-lipoxygenase in the colonic tumorigenesis promoted by cigarette smoke, Program and Proceedings of the AACR-NCI-EORTC International Conference, November 17-21, Hynes Center, Boston, USA. 2003, B54.
Ye Y., Liu S.L.E., Shin V.Y., Wu K.K., Luo J. and Cho C.H., Nicotine Promoted Colon Cancer Growth via Epidermal Growth Factor Receptor, c-Src, and 5-Lipoxygenase-Mediated Signal Pathway, The Journal of Pharmacology and Experimental Therapeutics. 2004, 308(1): 66-72.
Ye Y., Shin V.Y. and Cho C.H., Nicotine promoted colon cancer growth via EGFR, c-Src and 5-lipoxygenase mediated signal pathway , The 8th Research Postgraduate Symposium, Faculty of Medicine, The University of Hong Kong, 13 December 2003. 59.
Ye Y., Shin V.Y. and Cho C.H., Therapeutic role of dual inhibition of cyclooxygenase-2 and 5-lipoxygenase in the colonic tumorigenesis promoted by cigarette smoke, The 95th American Association for Cancer Research Meeting, March 27-31, Orlando, Florida. 2004, 3862.


Researcher : Yeung KY
List of Research Outputs

Yeung K.Y. and Man R.Y.K., Puerarin, an isoflavonoid derived from radix puerariae, potentiates endothelium-independent vasorelaxation via cAMP-dependent second messenger pathway in porcine coronary artery, The 9th Southeast Asian-Western Pacific Regional Meeting of Pharmacologists. 2003, 7, Suppl. 1: 90.


Researcher : Yip CW
List of Research Outputs

Au Y.K.W., Woo W.H.C., Sung L., Yip C.W., Siow Y.L. and O K., Hyperhomocysteinemia Activates Nuclear Factor-kB in Endothelial Cells via Oxidative Stress, Circulation Research. 2004, 94: 28-36.
O K., Sung L., Au Y.K.W., Yip C.W. and Siow Y.L., Homocysteine activates nuclear factor kappa-B in endothelial cells: Role of oxidative stress, The XIIIth International Symposium on Atherosclerosis, 28 September-2 October, Japan. 2003, 2P-0375.


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