Dept of Medicine

THE UNIVERSITY OF HONG KONG
Research and Scholarship 2004

DEPARTMENT OF MEDICINE

Researcher : Ambekar CS

List of Research Outputs

Ambekar C.S., Kumana C.R., Liang R.H.S. and Cheung B.M.Y., Chloramphenicol succinate as a competitive substrate and inhibitor of succinate dehydrogenase: relation to its mechanisms of toxicity, Hong Kong Medical Journal. 2003, 9(1) Suppl: 64.

Ambekar C.S., Lee J.S.K., Cheung B.M.Y., Chan L.C., Liang R.H.S. and Kumana C.R., Chloramphenicol succinate, a competitive substrate and inhibitor of succinate dehdrogenase : possible reason for its toxicity., Toxicology in Vitro. 2004, 18: 441-447.

Ambekar C.S., Kumana C.R., Liang R.H.S. and Cheung B.M.Y., Traditional Chinese medicine: effect on bone marrow and peripheral blood cell counts and enzyme induction, Hong Kong Medical Journal. 2003, 9(1) Suppl: 63.

Researcher : Au WY

List of Research Outputs

Au W.Y., Lie A.K.W., Liang R.H.S., Kwong Y.L., Yau C.C., Cheung M.M.C., Ngan K.C., Lau W.H., Wong K.H., Yiu H.Y., Cheng H.C., Au K.H. and Chang J.K.C., Autologous stem cell transplantation for nasal NK/T-cell lymphoma: a progress report on its value, Annals of Oncology. 2003, 14: 1673-1676.

Au W.Y., Ooi C.G.C., Yau W.F., Ma E.S.K., Wan T.S.K. and Kwong Y.L., Chronic myeloid leukemia in an adolescent with Ollier’s diease after intensive X ray exposure, Leukemia and Lymphoma. 2004, 45: 613-616.

Au W.Y., Wong R.W.M., Khoo U.S. and Liang R.H.S., Concurrent aggressive gastrointestinal stromal tumour (GIST) and Burkitt’s lymphoma., Journal of Clinical Oncology. 2003, 21: 1417 – 1418.

Au W.Y., Tsang J., Cheng T.S..., Chow W.S., Woo Y.C., Ma E.S.K. and Tam S.C.F., Cough mixture abuse as a novel cause of megaloblastic anemia and peripheral neuropathy, British Journal of Haematology. 2003, 123: 956-958.

Au W.Y., Ma S.Y., Ooi C.G.C. and Lie A.K.W., Disseminated zoster, hyponatremia, severe abdominal pain and leukemia relapse: an extended clinical quartet after bone marrow transplantation, British Journal of Dermatology. 2003, 148: 862-865.

Au W.Y., Fung A., Chim J.C.S., Lie A.K.W., Liang R.H.S., Ma E.S.K., Chan C.H., Wong K.F. and Kwong Y.L., FLT-3 aberrations in acute promyelocytic leukaemia: clinicopathological associations and prognostic impact, British Journal of Haematology. 2004, 125(4): 463-469.

Au W.Y., Gascoyne R.D., Gallaghar R.E., Nhu L., Klasa R.D., Liang R.H.S., Choy C.K.W., Foo W. and Connors J.M., Hodgkin's disease in Chinese migrants to British Columbia: a 25-year survey, Annals of Oncology. 2004, 15: 626-630.

Au W.Y., Lie A.K.W., Ma E.S.K., Lau G., Chan C. and Kwong Y.L., Late onset pure red cell aplasia due to delayed lymphoid engraftment complicating ABO mismatched hematopoietic stem cell transplantaion, Transfusion. 2004, 44: 946-947.

Au W.Y., Fung T.K., Ma E.S.K., Liang R.H.S. and Kwong Y.L., Low frequency of FLT3 gene internal tandem duplication and activating loop mutation in therapy-related acute myelocyticleukemia and myelodysplastic syndrome, Cancer Genetics and Cytogenetics. 2004, 149(2): 169-172.

Au W.Y., Cheng V.C.C., Ho P.L., Yuen K.Y., Hung I., Ma S.Y., Lie A.K.W., Liang R.H.S. and Kwong Y.L., Non tuberculous mycobacterial infections in Chinese hematopoietic stem cell transplantation recipients., Bone Marrow Transplantation. 2003, 32: 709-714.

Au W.Y., Kumana C.R., Kou M., Mak R., Chan G.C.F., Lam C.W. and Kwong Y.L., Oral arsenic trioxide in the treatment of relapsed acute promyelocytic leukemia, Blood. Washington, American Society of Hematology, 2003, 102(1): 407-408.

Au W.Y., Ho K.S. and Shek T.W.H., Papillary renal cell carcinoma and gastrointestinal stromal tumor: a novel association, Annals of Oncology. 2004, 15: 843-844.

Au W.Y., Ma E.S.K., Wan T.S.K., Man C.W.Y. and Kwong Y.L., Pentasomy 8q after cyclophosphamide therapy for fibrosing alveolitis: case report and review, Cancer Genetics and Cytogenetics. 2003, 141: 79-82.

Au W.Y., Chan C.P., Chung L.P. and Choy C.K.W., Primary B-Cell lymphoma and lymphoma-like lesions of the uterine cervix, American Journal of Hematology. 2003, 73: 176-179.

Au W.Y., Pang A.W.K., Choy C.K.W., Chim J.C.S. and Kwong Y.L., Quantification of circulating Epstein-Barr virus (EBV) DNA in the diagnosis and monitoring of natural killer cell and EBV-positive lymphomas in immunocompetent patients, Blood. 2004, 104(1): 243-9.

Au W.Y., Wong R.W.M., Wong B.C.Y., Lie A.K.W., Liang R.H.S., Leung A.Y.H. and Kwong Y.L., Reduced incidence of acute graft versus host disease of the gut in Chinese carriers of Helicobacter pylori during allogeneic bone marrow transplantation, Annals of Hematology. 2004, 83: 34-37.

Au W.Y., Lam C.C.K. and Kwong Y.L., Successful treatment of acquired factor VIII inhibitor with cyclosporine, Haemophilia. 2004, 10: 98-100.

Au W.Y., Lam C.C.K., Lie A.K.W., Pang A.W.K. and Kwong Y.L., T-cell large granular lymphocyte leukemia of donor origin after allogeneic bone marrow transplantation, Americal Journal of Clinical Pathology. 2003, 120: 626-30.

Au W.Y., Gascoyne R.D., Klasa R.J., Viswanatha D.S., Horsman D.E. and Connors J.M., The spectrum of lymphoma with 8q24 aberrations: a clinical, pathological and cytogenetic study of 87 consecutive cases, Leukemia & lymphoma. 2004, 45: 519-528.

Au W.Y., Lie A.K.W., Siu L.L.P., Chan C., Ooi C.G.C., Leung A.Y.H., Liang R.H.S. and Kwong Y.L., Treatment of lymphoma relapses after allogeneic hematopoietic stem cell transplantation with intensive chemotherapy followed by infusion of hematopoietic stem cell from the original donor, Annals of Hematology. 2003, 82(9): 548-551.

Au W.Y., Lie A.K.W., Chan C., Pang A.W.K., Liang R.H.S., Ma E.S.K., Choy C.K.W. and Kwong Y.L., Treatment of post-renal transplantation lymphoproliferative disease manifesting as plasmacytoma with non-myeloablative hematopoietic stem cell transplantation from the same kidney donor, American Journal of Hematology. 2003, 74: 283-6.

Au W.Y., Cheung W.C., Lam C.C.K. and Kwong Y.L., Two factor XI gene mutations in a Chinese family with factor XI deficiency, American Journal of Hematology. 2003, 74: 136-8.

Au W.Y., Lam C.C.K., Lam C.C.K., Lam C.C.K., Cheung W.C. and Kwong Y.L., Two novel factor X deficiency mutations in a Chinese family, Annals of Hematology. 2004, 83: 304-306.

Chan G.S.W., Lam M.F., Au W.Y. and Chan K.W., Pathologic quiz case: renal impairment after bone marrow transplantation. Bone marrow transplant nephropathy, Archives of Pathology and Laboratory Medicine. 2004, 128(2): 233–234.

Chen Y.W., Liang A.C.T., Au W.Y., Chu K.M., Wong K.Y., Hu X., Lu L., Tang J.C.O., Chan K.W., Beh S.L., Kwong Y.L., Liang R.H.S. and Srivastava G., Multiple BCL6 translocation partners in individual cases of gastric lymphoma, Blood. 2003, 102: 1931-1932.

Cheung T.Y.G., Yuen W.H., Kwong Y.L., Au W.Y., Man R.Y.K., Wong W.I. and Kumana C.R., Monitoring blood arsenic in outpatients with acute promyelocytic leukemia receiving oral arsenic trioxide, The 9th Southeast Asian-Western Pacific Regional Meeting of Pharmacologists. 2003, 7, Suppl. 1: 99.

Chim J.C.S., Ma A.Y., Au W.Y., Choy C.K.W., Lie A.K.W., Liang R.H.S., Yau C.C. and Kwong Y.L., Primary nasal natural killer cell lymphoma : long term treatment outcome and relationship with the international prognostic index., Blood. 2004, 103: 216-221.

Hon C., Au W.Y., Chung L.P. and Choy C.K.W., Allogeneic stem cell transplantation for therapy related leukemia after bilateral retinoblastoma in a girl with del(13q) syndrome, Annals of Hematology. 2004, 75: 115-6.

Hon C., Chan G.C.F., Ha S.Y., Ma E.S.K., Wong K.F. and Au W.Y., Bone marrow transplantation for therapy-related acute myeloid leukemia in congenital retinoblastoma associated with 13q deletion syndrome, Annals of Hematology. Springer-Verlag, 2004, 83: 481-483.

Hon C., Au W.Y., Shek T.W.H. and Shek T.W.H., Isolated sphenoid plasmacytoma presenting as painful ophthalmoplegia, Haematologica. 2003, 88:(08): EIM10.

Hon C., Kwok A.K., Shek T.W.H. and Au W.Y., Unusual locations of involvement by malignancies: Case 4. Bilateral hypopyon heralding CNS relapse of cutaneous natural killer cell lymphoma, Journal of Clinical Oncology. 2003, 21(17): 3373-4.

Khong P.L., Chan G.C.F., Lee S.L., Au W.Y., Fong D.Y.T., Tsang K.W.T. and Ooi C.G.C., b-Thalassemia Major: Thin-Section CT Features and Correlation with Pulmonary Function and Iron Overload, Radiology. 2003, 229: 507-512.

Kumana C.R., Au W.Y., Lee N.S., Kou M., Mak R.W.M., Lam C.W. and Kwong Y.L., Bioavailability of arsenic trioxide solubalised for oral administration to patients with haemic malignancies (P-11), In: FC Tuluney, M Orme, Sixth Congress of European Association of Clinical Pharmacology adn Therapeutics - European Collaboration: Towards Drug Development and Rational Drug Therapy. 2003, 73.

Lam M.F., Tse K.C., Chan K.W. and Au W.Y., Acute renal tubular necrosis due to grass carp ingestion in a myeloma patient after allogeneic stem cell transplantation, Bone Marrow Transplantation. 2004, 33: 669-670.

Lau G., Yiu H.H.Y., Fong D.Y.T., Cheng H.C., Au W.Y., Lai L.S.F., Cheung M., Zhang H.Y., Lie A.K.W., Ngan K.C. and Liang R.H.S., Early Is Superior to Deferred Preemptive Lamivudine Therapy for Hepatitis B Patients Undergoing Chemotherapy, Gastroenterology. 2003, 125: 1742-1749.

Lee C.K., Ma E.S.K., Shek T.W.H., Lam C.C.K., Au W.Y., Wan T.S.K. and Chan L.C., Plasmablastic transformation of multiple myeloma, Human Pathology. 2003, 34(7): 710-714.

Ma E.S.K., Au W.Y., Lie A.K.W., Ng I.O.L., Leung A.Y.H., Tse E.W.C., Liang R.H.S., Lau G. and Kwong Y.L., Liver graft-versus-host disease after donor lymphocyte infusion for relapses of hematologic malignancies post allogeneic hematopoietic stem cell transplantation, Bone Marrow Transplantation. 2004, 34: 57-61.

Ma S.Y., Au W.Y., Chim J.C.S., Lie A.K.W., Lam C.C.K., Tse E.W.C., Leung A.Y.H., Liang R.H.S. and Kwong Y.L., Fludarabine, mitoxantrone and dexamethasone in the treatment of indolent B-and T-cell lymphoid malignancies Chinese patients, British Journal of Haematology. 2004, 124: 754-761.

Ma S.Y., Au W.Y., Ng I.O.L., Lie A.K.W., Liang R.H.S., Lau G. and Kwong Y.L., Hepatitic graft-versus-host disease after hematopoietic stem cell transplantation : clinicopathologic features and prognostic implication, Transplantation. 2004, 77: 1252-1259.

Ma S.Y., Lie A.K.W., Au W.Y., Chim J.C.S., Kwong Y.L. and Liang R.H.S., Non-myeloablative allogeneic peripheral stem cell transplantation for multiple myeloma, Hong Kong Medical Journal. 2004, 10: 77-83.

Shen L., Liang A.C.T., Lu L., Au W.Y., Wong K.Y., Tin P.C., Chan K.W., Ko K.H., Chen W.Y.W., Beh S.L., Shimizu N., Tsuchiyama T., Tang J.C.O., Kwong Y.L., Liang R.H.S. and Srivastava G., Aberrant BCL10 nuclear expression in nasal NK/T-cell lymphoma, Blood. 2003, 102(4): 1553-1554.

Shen L., Liang A.C.T., Au W.Y., Lu L., Chen W.Y.W., Wong K.Y., Tang J.C.O., Chan K.W., Beh S.L., Kwong Y.L., Liang R.H.S. and Srivastava G., BCL10 mutations are irrelevant to its aberrant nuclear localization in nasal NK/T-cell lymphoma, Leukemia. 2003, 17(11): 2240-2242.

Wan T.S.K., Ma E.S.K., Lam C.C.K., Chan L.C., Lee K.K. and Au W.Y., Deletion 9q as the sole karyotypic abnormality in myelocytic disorders: a new case of myelodysplastic syndrome and its prognostic implications in acute myelocytic leukemia, Cancer Genetics and Cytogenetics. 2003, 145(2): 184-186.

Researcher : Chan C

List of Research Outputs

Au W.Y., Lie A.K.W., Ma E.S.K., Lau G., Chan C. and Kwong Y.L., Late onset pure red cell aplasia due to delayed lymphoid engraftment complicating ABO mismatched hematopoietic stem cell transplantaion, Transfusion. 2004, 44: 946-947.

Au W.Y., Lie A.K.W., Siu L.L.P., Chan C., Ooi C.G.C., Leung A.Y.H., Liang R.H.S. and Kwong Y.L., Treatment of lymphoma relapses after allogeneic hematopoietic stem cell transplantation with intensive chemotherapy followed by infusion of hematopoietic stem cell from the original donor, Annals of Hematology. 2003, 82(9): 548-551.

Au W.Y., Lie A.K.W., Chan C., Pang A.W.K., Liang R.H.S., Ma E.S.K., Choy C.K.W. and Kwong Y.L., Treatment of post-renal transplantation lymphoproliferative disease manifesting as plasmacytoma with non-myeloablative hematopoietic stem cell transplantation from the same kidney donor, American Journal of Hematology. 2003, 74: 283-6.

Researcher : Chan CH

List of Research Outputs

Au W.Y., Fung A., Chim J.C.S., Lie A.K.W., Liang R.H.S., Ma E.S.K., Chan C.H., Wong K.F. and Kwong Y.L., FLT-3 aberrations in acute promyelocytic leukaemia: clinicopathological associations and prognostic impact, British Journal of Haematology. 2004, 125(4): 463-469.

Researcher : Chan CK

List of Research Outputs

Chow W.S., So T., Tan K.C.B., Choy A., Hung V., Hui C.K., Chu D., Chan C.K. and Lam K.S.L., An evaluation of the effectiveness of a step-down clinic for diabetes in Hong Kong, 18th Congress of International Diabetes Federation, 24-29 Aug 2003, Paris, France. 2003, A103(286).

Hui C.K., Lai K.C., Yuen M.F., Ng M.M.T., Chan C.K., Hu H.C., Wong R.W.M., Lai C.L. and Wong B.C.Y., Does the Addition of Endoscopic Sphincterotomy to Stent Insertion Improve Drainage of the Bile Duct in Acute Suppurative Cholangitis?, Gastrointestinal Endoscopy. 2003, 58(4): 500-4.

Hui C.K., Lai K.C., Yuen M.F., Wong R.W.M., Chan O.O., Ng M.M.T., Chan C.K., Cheung W.W., Lam S.K., Lai C.L. and Wong B.C.Y., The Role of Cholecystectomy in Reducing Recurrent Gallstone Pancreatitis, Endoscopy. 2004, 36(3): 206-11.

Lai K.C., Lam S.K., Chu K.M., Hui W.M., Kwok K.F., Wong B.C.Y., Hu H.C., Wong R.W.M., Chan O.O. and Chan C.K., Lansoprazole Reduces Ulcer Relapse after Eradication of Helicobacter pylori in Nonsteroidal Anti-Inflammatory Drug Users--a Randomized Trial, Alimentary Pharmacology and Therapeutics. 2003, 18(8): 829-36.

Wong B.C.Y., Wong R.W.M., Cheung K.L., Tong S.M., Rozen P., Young G.P., Chu K.W., Ho J.W.C., Law W.L., Tung H.M., Lai K.C., Hu H.C., Chan C.K. and Lam S.K., A Sensitive Guaiac Fecal Occult Blood Test is Less Useful than an Immunochemical Test for Colorectal Cancer Screening in a Chinese Population , Alimentary Pharmacology and Therapeutics. 2003, 18(9): 941-946.

Wong R.W.M., Lam K.F., Cheng C., Hui W.M., Xia H.H.X., Lai K.C., Hu H.C., Huang J., Lam C.L.K., Chan C.K., Chan O.O., Lam S.K. and Wong B.C.Y., Population Based Study of Noncardiac Chest Pain in Southern Chinese: Prevalence, Psychosocial Factors and Health Care Utilization, World Journal of Gastroenterology. 2004, 10(5): 707-712.

Wong W.M., Gu Q., Wang W., Fung F.M.Y., Berg D.E., Lai K.C., Xia H.H.X., Hu H.C., Chan C.K., Chan O.O., Yuen M.F., Hui C.K., Lam S.K. and Wong B.C.Y., Effects of Primary Metronidazole and Clarithromycin Resistance to Helicobacter pylori on Omeprazole, Metronidazole, and Clarithromycin Triple-Therapy Regimen in a Region with High Rates of Metronidazole Resistance, Clinical Infectious Diseases. 2003, 37(7): 882-9.

Wong W.M., Lam S.K., Tong S.M., Cheung K.L., Tang V.S.Y., Xia H.H.X., Lai K.C., Hu H.C., Chan C.K., Yuen M.F., Chan O.O. and Wong B.C.Y., Evaluation of a Rapid Stool Antigen Test for the Diagnosis of Helicobacter pylori Infection in Chinese Patients, Chinese Journal of Digestive Diseases. 2003, 4: 132-135.

Wong W.M., Lai K.C., Lam K.F., Hui W.M., Hu H.C., Lam C.L.K., Xia H.H.X., Huang J., Chan C.K., Lam S.K. and Wong B.C.Y., Prevalence, Clinical Spectrum and Health Care Utilization of Gastro-Oesophageal Reflux Disease in a Chinese Population: a Population-Based Study, Alimentary Pharmacology and Therapeutics. 2003, 18(6): 595-604.

Researcher : Chan CY

List of Research Outputs

Zhang Q., Yung S.S.Y., Leung J.K.H. and Chan C.Y., Alpha-actinin and F-actin expression is modulated by elevated glucose concentration in human mesangial cells, 9th Medical Research Conference. 7-8 February . 2004, Abstract NP-05.

Researcher : Chan DTM

Project Title:	Internalization of human anti-DNA antibodies by mesangial cells - the role of a-actinin and actin
Investigator(s):	Prof. Chan D.T.M., Dr. Yung S.S.Y.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2002

Abstract:

To examine the role of a-actinin and actin in the binding and internalization of anti-DNA antibodies by HMC; to investigate the synthesis of a-actinin and actin in HMC after this process; to determine the effect of anti-DNA antibody internalization on HMC morphology, proliferation, and viability, and its synthesis and secretion of IL-1b, IL-6 and TNF-a.

Project Title:	Internalization of anti-DNA antibodies from patients with lupus nephritis by human mesangial cells
Investigator(s):	Prof. Chan D.T.M., Dr. Yung S.S.Y.
Department:	Medicine
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	11/2003

Abstract:

To characterize HMC membrane and intracellular molecules responsible for binding to anti-DNA antibodies-by trypsin, papain, or pepsin digestion, Western blotting, and protein sequencing; to examine the relationship between the properties of human anti-dsDNA antibodies (isoelectric point, binding to HMC, cellular internalization), their correlation with clinical disease activity, and their effects on cell function, morphology, proliferation, and apoptosis; to elucidate the mechanisms by which anti-dsDNA antibodies bind and penetrate plasma membrane, traverse the cytoplasm, and enter the nucleus of HMC. This will be achieved by kinetic studies using timed flow cytometry, immunohistochemistry, and confocal microscopy. The latter will also be used to investigate the binding between anti-dsDNA antibodies and cytoskeletal structures including myosin. The effects of anti-dsDNA antibodies in the presence or absence of DNA and histones on the synthesis of cytoskeletal molecules will be examined by radiolabelling and immunoprecipitation.

Project Title:	Internalization of anti-DNA antibodies from patients with lupus nephritis by human mesangial cells
Investigator(s):	Prof. Chan D.T.M., Dr. Yung S.S.Y.
Department:	Medicine
Source(s) of Funding:	RGC Projects (Block Grant Funded)
Start Date:	11/2003

Abstract:

Project Title:	Modulation of human mesangial cell F-actin and focal adhesion plaque synthesis in diabetic nephropathy
Investigator(s):	Prof. Chan D.T.M., Dr. Yung S.S.Y.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2003

Abstract:

To examine the effect of physiological (5mM) and elevated (10mM and 30mM) D-glucose concentrations on cultured human mesangial cells (HMC) viability, proliferation, and activation - the latter will be determined by a-smooth muscle actin staining; to determine how physiological and elevated glucose concentrations modulate F-actin, a-actinin, vinculin and PKC expression; to determine the morphological changes of HMC cytoskeletal components by scanning and transmission electron microscopy.

List of Research Outputs

Chan D.T.M., Tsang R.C.W., Leung J.K.H. and Yung S.S.Y., Modulation of hyaluronan synthesis in human mesangial cells after stimulation with Anti-DNA antibodies from patients with lupus nephritis, Journal of American Society of Nephrology. 2003, 14: 594A.

Chan D.T.M., Systemic Luplus Erythematosus - Recent Progress in Clinical and Basic Research, Sir David Todd Lecuture, Nov. 2003.

Chan L.Y., Leung J.C.K., Tsang W.L., Chan D.T.M., Tang S.C.W. and Lai K.N., Activation Of Human Proximal Renal Tubular Epithelial Cells By Mediators Released From Mesangial Cells Cultured With IgA, Journal of the American Society of Nephrology. 2003, 14: 375A.

Chong W.P., Ip E.W.K., Lau W.C.S., Chan D.T.M., Padyukov L. and Lau Y.L., Common NOD2 polymorphisms in Hong Kong Chinese patients with systemic lupus erythematosus, Rheumatology. 2004, 43: 104-105.

Choy C.B.Y., Chan D.T.M., Lo R.S.K., Lo W.K. and Lai K.N., Renal transplantation in patients with primary immunoglobulin A nephropathy, Nephrology Dialysis Transplantation. 2003, 18: 2399-2404.

Guo H., Leung J.C.K., Chan L.Y., Chan D.T.M. and Lai K.N., The pathogenetic role of immunoglobulin G from patients with systemic lupus erythematosus in the development of lupus pleuritis, Rheumatology. 2004, 43: 286-293.

Kong E.K.P., Prokunina L., Chan D.T.M., Lau W.C.S., Alarcon-Riquelme M.E. and Lau Y.L., Analysis of a new potentially regulatory polymorphism in the PDCD1 gene in systemic lupus erythematosus, Human Genome Meeting. 2004, Poster Number 92.

Kumana C.R., Tong M.K.L., Li C.S., Lauder I.J., Lee J.S.K., Kou M., Walley T., Haycox A. and Chan D.T.M., Diltiazem co-treatment in renal transplant patients receiving microemulsion cyclosporin, British Journal of Clinical Pharmacology. Blackwell Publishing, 2003, 56(6): 670-678.

Lam M.F., Lo W.K., Lui S.L., Li F.K., Chan D.T.M. and Lai K.N., Eosinophilic Peritonitis Has Deleterious Effect On Peritoneal Dialysis Patients Survival, Journal of the American Society of Nephrology. 2003, 14: 862A.

Li F.K., Lai C.K., Poon W.T., Chan A.Y.W., Chan K.W., Tse K.C., Chan D.T.M. and Lai K.N., Aggravation of non-steroidal anti-inflammatory drug-induced hepatitis and acute renal failure by slimming drug containing anthraquinones, Nephrology Dialysis Transplantation. 2004, 19(7): 1916-1917.

Li F.K., Yip T., Tse K.C., Chan D.T.M. and Lai K.N., Artificial Stiffness And Central Aortic Blood Pressure As Determined By Pulse Wave Analysis In Chronic Dialysis And Post-Renal Transplant Patients, Journal of the American Society of Nephrology. 2003, 14: 535A.

Li F.K., Tse K.C., Lam M.F., Yip T.P.S., Lui S.L., Chan G.S.W., Chan K.W., Chan E.Y.T., Choy C.B.Y., Lo W.K., Chan D.T.M. and Lai K.N., Incidence and outcome of antiglomerular basement membrane disease in Chinese, Nephrology (Carlton). 2004, 9: 100-104.

Lui S.F., Li F.K., Choy C.B.Y., Chan D.T.M., Lo W.K. and Lai K.N., Long-term Outcome of Isoniazid Prophylaxis Against Tuberculosis in Chinese Renal Transplant Recipients. , Transplant Infectious Disease. 2004, 6: 55-56.

Lui S.L., Chan D.T.M., Lo W.K. and Lai K.N., Chronic inflammatory demyelinating polyneuropathy after initiation of peritoneal dialysis--a distinct clinical entity?, International Journal of Artificial Organs. 2003, 26: 969-971.

Mok T.M.Y., Lao T.T.H., Collins R.J., Leung T.Y., Leung P.Y., Chan D.T.M., Wong R.W.S. and Lau W.C.S., Cervical dysplasia in patients with systemic lupus erythematosus, 7th International Congress on SLE and Related Condidtions, New York. 2004.

Mok T.M.Y., Lao T.T.H., Collins R.J., Leung T.Y., Leung P.Y., Lo Y., Chan D.T.M., Wong R.W.S. and Lau W.C.S., Cervical dysplasia in patients with systemic lupus erythematosus, The Hong Kong Practitioner. 2004, 2: RI-05.

Mok T.M.Y., Leung P.Y., Lao T.T.H., Lo Y., Chan D.T.M., Wong R.W.S. and Lau W.C.S., Clinical predictors of fetal and maternal outcome in Chinese patients with systemic lupus erythematosus, 7th International Congress on SLE and Related Conditions, New York. 2004.

Mok T.M.Y., Leung P.Y., Lao T.T.H., Chan D.T.M., Wong R.W.S. and Lau W.C.S., Clinical predictors of fetal and maternal outcome in Chinese patients with systemic lupus erythematosus, The Hong Kong Practitioner. 2004, 2: RI-053.

Mok T.M.Y., Lo Y., Chan D.T.M., Wong R.W.S. and Lau W.C.S., Efficacy of chemotherapy for tuberculosis infection in patients with systemic lupus erythematosus in an endemic area, The Hong Kong Practitioner. 2003, 9(Suppl 1): 65.

Tang S.C.W., Leung J.C.K., Tang A., Ho Y.W., Chan L.Y., Chan D.T.M. and Lai K.N., A Prospective, Randomized, Case-Controlled Study On The Efficacy Of Mycophenolate Mofetil For IgA Nephropathy Patients With Persistent Proteinuria Despite Angiotensin Blockade, Journal of the American Society of Nephrology. 2003, 14: 752A.

Tang S.C.W., Lui S.L., Lo C.Y., Lo W.K., Cheng I.K.P., Lai K.N. and Chan D.T.M., Spousal renal donor transplantation in Chinese subjects: a 10 year experience from a single centre, Nephrology Dialysis Transplantation. 2004, 19: 203-206.

Tang S.C.W., Cheng I.K.P., Leung V.K.S., Kuok U.I., Tang A.W.C., Ho Y.W., Lai K.N. and Chan D.T.M., Successful treatment of hepatitis C after kidney transplantation with combined interferon alpha-2b and ribavirin, Journal of Hepatology. 2003, 39: 875-878.

Tse K.C., Lam M.F., Yip P.S., Li F.K., Lai K.N. and Chan D.T.M., A long-term study on hyperlipidemia in stable renal transplant recipients, Clinical Transplantation. 2004, 18: 274-280.

Tse K.C., Chan D.T.M., Wong S.S.Y., Chan K.W., Lam M.F., Chan K.H.N., Li F.K., Chung B.C.Y. and Lai K.N., Granulomatous interstitial nephritis of the allograft kidney associated with rhodococcal pulmonary infection. Nephrol Dial Transplant, Nephrology Dialysis Transplantation. 2004, 19: 486-490.

Tse K.C., Lam M.F., Yip P.S., Li F.K., Choy C.B.Y., Lai K.N. and Chan D.T.M., Idiopathic Minimal Change Nephrotic Syndrome In Older Adults: Steroid Responsiveness And Pattern Of Relapses, Nephrology, Dialysis and Transplantation. 2003, 18: 1316-1320.

Tse K.C., Li F.K., Chan D.T.M. and Lai K.N., Listeria Monocytogenes Peritonitis Complicated By Septic Shock In A Patient On Continuous Ambulatory Peritoneal Dialysis, Clinical Nephrology. 2003, 60: 61-62.

Tse K.C., Yip P.S., Lam M.F., Choy C.B.Y., Li F.K., Lui S.L., Lo W.K., Chan D.T.M. and Lai K.N., Star Fruit Intoxication In Uraemic Patients: Case Series And Review Of The Literature, Internal Medicine Journal. 2003, 33: 314-316.

Wang T.K.F., Chiu W., Chim S., Chan D.T.M. and Wong S.S.Y., Disseminated ochroconis gallopavum infection in a renal transplant recipient: the first reported case and a review of the literature, Clinical Nephrology. 2003, 2003; 60(6): 415-23.

Yung S.S.Y., Leung J.K.H., Liu Z.H., Li L.S. and Chan D.T.M., Emodin abrogates peritoneal dialysate induction of pro-inflammatory/fibrotic mediators and morphological changes in human peritoneal mesothelial cells, 9th Medical Reserach Conference. 7-8 February. 2004, Abstract NP-01.

Yung S.S.Y., Leung J.K.H., Liu Z.H., Li L.S. and Chan D.T.M., Emodin abrogates peritoneal dialysis fluid induction of matrix protein synthesis and morphologic changes in human peritoneal mesothelial cells, Journal of American Society of Nephrology. 2003, 14: 645A.

Yung S.S.Y. and Chan D.T.M., Preventing peritoneal fibrosis - Insights from the laboratory, Peritoneal Dialysis International. 2003, 23: S37-S41.

Yung S.S.Y., Chen X., Tsang R.C.W., Zhang Q. and Chan D.T.M., Reduction of perlecan synthesis and induction of TGF-beta 1 in human peritoneal mesothelial cells due to high glucose concentration - implication in peritoneal dialysis, Journal of American Society of Nephrology. 2004, May 15 (5): 1178-1188.

Researcher : Chan HHL

Project Title:	The role of epidermal cooling in improving the outcome of laser therapy in the treatment of Nevus of Ota
Investigator(s):	Dr. Chan H.H.L., Dr. Lam L.K.
Department:	Medicine
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	12/2000

Abstract:

To assess whether epidermal cooling would reduce pain, swelling, complications but improve clinical response and reduce the number of session required for laser treatment for Nevus of Ota.

Project Title:	The use of vascular lasers in the treatment of port wine stain in chinese
Investigator(s):	Dr. Chan H.H.L., Prof. Wei W.I.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2001

Abstract:

To establish the importance of epidermal cooling when 585nm pulse dye laser is used for the treatment of port wine stain in Chinese; to compare the clinical efficacy, patients' tolerability and complications of two commerical available vascular lasers that are equipped with different cooling devices in the treatment of port wine stain in Chinese.

List of Research Outputs

Chan H.H.L., Lam L.K., Wong S.Y. and Wei W.I., Role of skin cooling in improving patient tolerability of Q-switched Alexandrite (QS Alex) laser in nervus of Ota treatment, Lasers in Surgery and Medicine. 2003, 32: 148-151.

Chan H.H.L., Lam L.K., Wong S.Y., Kono T. and Trendall-Smith N., Use of 1,320 nm Nd:YAG laser for wrinkle reduction and the treatment of atrophic acne scarring in Asians, Lasers in Surgery and Medicine. 2004, 34: 98-103.

Researcher : Chan JCK

Project Title:	Application of the APACHE II and III prognostic scoring methods in the 14-bed Intensive Care Unit at Queen Mary Hospital
Investigator(s):	Dr. Chan J.C.K., Prof. Lam W.K.
Department:	Medicine
Source(s) of Funding:	Health Services Research Fund
Start Date:	07/1995

Abstract:

To evaluate the usefulness of the APACHE II and III prognostic scoring methods in the 14-bed ICU at Queen Mary Hospital; to compare our ICU performance in terms of actual mortality with the predicted mortality based on the APACHE II predictive equation; to correlate the APACHE II and III severity scores. As the mortality prediction equation for APACHE III is only commercially available, a close correlation between APACHE II and III scores would support using the APACHE II scoring and prediction method as the standard method rather than financially investing in the APACHE III system.

Project Title:	Application of the APACHE II and III prognostic scoring methods in the 14-bed Intensive Care Unit at Queen Mary Hospital
Investigator(s):	Dr. Chan J.C.K., Prof. Lam W.K.
Department:	Medicine
Source(s) of Funding:	Queen Mary Hospital Charitable Trust Training and Research Assistance Scheme
Start Date:	07/1995

Abstract:

Researcher : Chan K

List of Research Outputs

Chan K., Wong M.S., Chan T.K. and Chan V.N.Y., A Thalassaemia Array For Southeast Asia, British Journal of Haematology. 2004, 124: 232-239.

Researcher : Chan KW

List of Research Outputs

Xu A., Yin S., Wong L.C., Chan K.W. and Lam K.S.L., Adiponectin ameliorates dyslipidemia induced by the human immunodeficiency virus protease inhibitor ritonavir in mice, Endocrinology . 2004, 145: 487-94.

Xu A., Yin S., Wong L.C., Chan K.W. and Lam K.S.L., The fat-derived hormone adiponectin ameliorates dyslipidemia induced by HIV protease inhibitors, 13th International Symposium on Atherosclerosis, September 28 – October 2, 2003, Kyoto, Japan. 2003.

Xu A., Yin S., Wong L.C., Chan K.W. and Lam K.S.L., The fat-derived hormone adiponectin ameliorates dyslipidemia induced by HIV protease inhibitors, 15th Annual Scientific Meeting of Hong Kong Society of Endocrinology, Metabolism and Reproduction, October 2003, Hong Kong. 2003.

Researcher : Chan LY

List of Research Outputs

Chan L.Y., Leung J.C.K., Tsang W.L., Chan D.T.M., Tang S.C.W. and Lai K.N., Activation Of Human Proximal Renal Tubular Epithelial Cells By Mediators Released From Mesangial Cells Cultured With IgA, Journal of the American Society of Nephrology. 2003, 14: 375A.

Guo H., Leung J.C.K., Chan L.Y., Chan D.T.M. and Lai K.N., The pathogenetic role of immunoglobulin G from patients with systemic lupus erythematosus in the development of lupus pleuritis, Rheumatology. 2004, 43: 286-293.

Lai K.N., Tang S.C.W., Guh J.Y., Chuang T.D., Lam M.F., Chan L.Y., Tsang W.L. and Leung J.C.K., Polymeric IgA1 from patients with IgA nephropathy upregulates transforming growth factor-beta synthesis and signal transduction in human mesangial cells via the renin-angiotensin system, Journal of American Society of Nephrology. 2003, 14: 3127-3137.

Leung J.C.K., Chan L.Y., Tsang W.L., Tang S.C.W. and Lai K.N., Anti-Macrophage Migration Inhibitory Factor Reduces Transforming Growth Factor-1b Expression In Experimental IgA Nephropathy, Journal of the American Society of Nephrology. 2003, 14: 408A.

Tang S.C.W., Leung J.C.K., Tang A., Ho Y.W., Chan L.Y., Chan D.T.M. and Lai K.N., A Prospective, Randomized, Case-Controlled Study On The Efficacy Of Mycophenolate Mofetil For IgA Nephropathy Patients With Persistent Proteinuria Despite Angiotensin Blockade, Journal of the American Society of Nephrology. 2003, 14: 752A.

Tang S.C.W., Leung J.C.K., Chan L.Y., Tsang W.L., Chen X., Zhou W., Lai K.N. and Sacks S.H., Regulation of complement C3 and C4 synthesis in human peritoneal mesothelial cells by peritoneal dialysis fluid, Clinical & Experimental Immunology. 2004, 136: 85-94.

Researcher : Chan MMW

Project Title:	Transmission of tuberculosis in Hong Kong using both molecular and conventional epidemiological methods
Investigator(s):	Prof. Chan M.M.W., Dr. Kam K.M., Dr. Tam C.M.
Department:	Medicine
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	09/2000
Completion Date:	02/2004

Abstract:

To conduct a molecular and conventional epidemiological study on all bacteriologically proven active cases of tuberculosis in Hong Kong Island over a period of 24 consecutive months.

Project Title:	Candidate gene polymorphisms associated with asthma and allergy in Hong Kong
Investigator(s):	Prof. Chan M.M.W., Prof. Ip M.S.M., Dr. Tan-Un K.C.
Department:	Medicine
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	09/2001

Abstract:

To recruit 150 Chinese patients with asthmas from the Asthma Clinic at the Queen Mary Hospital in Hong Kong; to phenotype these patients according to their asthma severity and atopic status; to determine the prevalence of some of the specific polymorphisms of genes associated with allergy and asthma; to recruit an equal number of controls without asthma and to determine the prevalence of specific polymorphisms of genes associated with allergy and asthma.

Project Title:	A surveillance program of tuberculosis in old age homes in Hong Kong
Investigator(s):	Prof. Chan M.M.W., Dr. Chu L.W., Dr. Dai D.L.K., Dr. Kam K.M., Prof. Lam W.K., Dr. Wong C.P.
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation Grant
Start Date:	11/2001

Abstract:

To conduct a cross-sectional screening examination for tuberculosis in old age homes in several districts in Hong Kong, SAR; to ensure that directly observed therapy (DOT) is given to those with active disease diagnosed through the screening program in collaboration with the Hong Kong Government Tuberculosis and Chest Service (Chest Service); to provide a screening examination for tuberculosis for new residents on entry to the old age homes participating in the program; to participate, in collaboration with the Chest Service, in contact examination on residents in the same home from which an active case of tuberculosis is being diagnosed; to provide education to the staff of old age homes on early recognition of tuberculosis, its treatment and possible side effects to evaluate the effectiveness of the program.

Project Title:	A surveillance program of tuberculosis in old age homes in Hong Kong
Investigator(s):	Prof. Chan M.M.W., Dr. Chu L.W., Dr. Dai D.L.K., Dr. Kam K.M., Prof. Lam W.K., Dr. Wong C.P.
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation Grant
Start Date:	01/2004

Abstract:

To conduct a cross-sectional screening examination for tuberculosis in old age homes in several districts in Hong Kong, SAR; to ensure that directly observed therapy (DOT) is given to those with active disease diagnosed through the screening program in collaboration with the Hong Kong Tuberculosis and Chest Service, Department of Health (Chest Service); to provide a screening examination for tuberculosis for new residents on entry to the old age homes participating in the program; to participate, in collaboration with the Chest Service, in contact examination on residents in the same home from which an active case of tuberculosis is being diagnosed; to provide education to the staff of old age homes on early recognition of tuberculosis, its treatment and possible side effects; to evaluate the effectiveness of the program.

List of Research Outputs

Becker A., Watson W., Ferguson A., Dimich-Ward H. and Chan M.M.W., The Canadian asthma primary prevention study: outcomes at 2 years of age, Journal of Allergy and Clinical Immunology . 2004, 113(4): 650-6.

Beyers N. and Chan M.M.W., From Africa to Asia., International Journal of Tuberculosis and Lung Disease. 2003, 7: 1-2.

Beyers N., Chan M.M.W. and Pierad C., Where do we go from here?, International Journal of Tuberculosis and Lung Disease. 2004, 8(1): 1-1(1).

Bresnitz E.A., Beckett W., Chan M.M.W. and Harber P., Guidelines for assessing and managing asthma risk at work, school and recreation., American Journal of Respiratory and Critical Care Medicine. 2004, 169(7): 873-81.

Chan M.M.W., 2003 Christie Memorial lecture. Occupational asthma - the past 50 years., Canadian Respiratory Journal. 2004, 11(1): 21-6.

Chan M.M.W., Ait-Khaled N., White N., Tsang K.W.T. and Tan W.C., Management of chronic obstructive pulmonary disease in Asia and Africa., International Journal of Tuberculosis and Lung Disease. 2004, 8(2): 159-70.

Chan M.M.W., Occupational asthma - global perspective., ACI International. 2003, 15: 203-207.

Chan M.M.W., Lam W.K., Mak J.C.W., Ho S.P., Chan R.H.W., Tsang K.W.T., Ip M.S.M., Ho J.C.M., Wong M.P. and Tan-Un K.C., Polymorphisms of CYP and GST genes, passive smoke and lung cancer risk in Hong Kong Chinese, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-11.

Chan M.M.W., Noertjojo K., Leung C.C., Chan S.L. and Tam C.M., Prevalence And Predictors Of Default From Tuberculosis Treatment In Hong Kong., Hong Kong Medical Journal. 2003, 9: 263-8.

Chan M.M.W. and Xu R.H., SARS: epidemiology., Respirology. 2003, 8 Suppl: S9-14.

Chan M.M.W., Severe Acute Respiratory Syndrome., Newsletter. Hong Kong Thoracic Society and ACCP (HK and Macau Chapter) . 2003, 13: 15-20.

Chan M.M.W., Seto W.H., Sung J.J., Lai T.S.T., Yee W., Yam L.Y.C., Tsang K.W.T., Ip M.S.M., Lam W.K. and Lai K.N., Severe Acute Respiratory Syndrome: Patients Were Epidemiologically Linked, British Medical Journal. 2003, 326: 1393.

Chan M.M.W., Ooi C.G.C., Hui D.S., Ho P.L. and Tsang K.W.T., Severe acute respiratory syndrome., International Journal of Tuberculosis and Lung Disease. 2003, 7(12): 1117-30.

Chan M.M.W., Ait-Khaled N., White N., Ip M.S.M. and Tan W.C., The burden and impact of COPD in Asia an Africa., International Journal of Tuberculosis and Lung Disease. 2004, 8(1): 2-14.

He J.Q., Chan M.M.W., Becker A.B., Dimich-Ward H., Ferguson A., Manfreda J., Watson W., Pare P. and Sandford A., Genetic variants of the IL13 and IL4 and the development of atopy and atopic diseases during the first two years of life in at risk children., Genes and Immunity: Genetics, Genomics and Function. 2003, 4: 385-389.

Ho A.S., Sung J.J.Y. and Chan M.M.W., An outbreak of severe acute respiratory syndrome (SARS) among hospital workers in a community hospital in Hong Kong., Annals of Internal Medicine. 2003, 139(7): 564-7.

Ho J.C.M., Lam W.K., Yan C.P.K., Ip S., Wong M., Lam J., Wang J., Lam C.L., Lam B., Chan M.M.W., Ip M.S.M. and Tsang K.W.T., A phase II study of vinorelbine monotherapy in the treatment of advanced nob-small cell lung cancer in the elderly, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-06.

Ho J.C.M., Ooi C.G.C., Mok T.Y., Chan J.W., Hung I., Lam B., Wong P.C., Li P.C., Ho P.L., Lam W.K., Ng C.K., Ip M.S.M., Lai K.N., Chan M.M.W. and Tsang K.W.T., High-dose pulse versus nonpulse corticosteroid regimens in severe acute respiratory syndrome, American Journal of Respiratory and Critical Care Medicine. 2003, 168: 1449-1456.

Ho J.C.M., Ooi C.G.C., Mok T.Y.M., Ho P.L., Chan M.M.W., Ip M.S.M., Lam W.K. and Tsang K.W.T., Initial pulse or non-pulse steroid therapy in patients with deteriorating severe acute respiratory syndrome, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia,2003. Abstract book PP6-14: p.193.

Ho J.C.M., Lam W.K., Ip S., Wong M. and Chan M.M.W., Local experience in the treatment of advanced lymphoepithelioma-like carcinoma of the lung, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-07.

Ho J.C.M., Ho S.P., Chan M.M.W., Mak J.C.W., Ip M.S.M., Wong M.P., Tsang K.W.T. and Lam W.K., Non-small cell lung cancer in Chinese is associated with disturbance in systemic antioxidants profiles , 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-03.

Ho J.C.M., Wu A.Y.Y., Ooi C.G.C., Lam B., Ho P.L., Chan M.M.W., Ip M.S.M., Lam W.K. and Tsang K.W.T., Pentaglobin as rescue therapy in patients with severe acute respiratory syndrome, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-04.

Ho J.C.M., Ooi C.G.C., Mok T.Y., Ho P.L., Chan M.M.W., Ip M.S.M., Lam W.K. and Tsang K.W.T., Pulse corticosteroid therapy in patients with severe acute respiratory syndrome, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-05.

Ho J.C.M., Ho S.P., Chan M.M.W., Ip M.S.M., Wong M.P., Tsang K.W.T. and Lam W.K., Systemic antioxidant profiles in non-small cell lung cancer in Chinese, The Journal of the Japanese Respiratory Society. 2004, 42 (suppl): 69.

Lam B., Ooi C.G.C., Wong M.P., Lee R., Ip M.S.M., Chan M.M.W., Lam W.K. and Tsang K.W.T., Extrapulmonary presentation of asymptomatic pulmonary lymphangioleiomyomatosis, Respirology. 2003, 8(4): 544-547.

Mak J.C.W., Ho S.P., Tsang K.W.T., Ip M.S.M., Yu W.C., Yew W.W. and Chan M.M.W., Increased transforming growth factor-beta 1 (TGF-beta 1) plasma level in Chinese patients with chronic obstructive pulmonary disease (COPD), American Thoracic Society International Conference, Orlando, USA. May 2004. 169(7): A838.

Manfreda J., Sears M.R., Becklake M.R., Chan M.M.W., Dimich-Ward H., Siersted H.C., Ernst P., Sweet L., Van Til L., Bowie D.M. and Anthonisen N.R., Geographic and gender variability in the prevlence of bronchial responsiveness in Canada., Chest. 2004, 125(5): 1657-64.

Ooi C.G.C., Tsang K.W.T., Cheung R.T.F., Khong P.L., Ho I.W.T., Ip M.S.M., Tan C.M., Ngan H., Lam W.K., Chan F.L. and Chan M.M.W., Silicosis in 76 men: qualitative and quantitative CT evaluation - clinical-radiologic correlative study., Radiology . 2003, 228(3): 816-25.

Sandford A.J., Chan H.W., Wong G.W., Lai C.K. and Chan M.M.W., Candidate genetic polymorphisms for asthma in Chinese schoolchildren from Hong Kong., International Journal of Tuberculosis and Lung Disease. 2004, 8(5): 519-27.

Tan-Un K.C., Chang K.R. and Chan M.M.W., Use of a food frequency questionnaire on Chinese diet to assess antioxidant status in individuals with asthma, Nutrition Research. 2004, 24: 509-519.

Tsang K.W.T., Ho P.L., Tan K.C., Ooi C.G.C., Ho J.C.M., Tipoe G.L., Lam W.K. and Chan M.M.W., Efficacy of 12-month treatment with inhaled corticosteroid in bronchiectasis, European Respiratory Journal. 2003, suppl 22(45): P3213.

Wong M.P., Tipoe G.L., Sun J.Z., Mak J.C.W., Ooi C.G.C., Ip M.S.M., Chan M.M.W., Lam W.K. and Tsang K.W.T., Clinical significance of ciliary abnormalities in bronchiectasis, Annual Scientific Meeting, Hong Kong Thoracic Society & American College of Chest Physicians, 2003. Abstract pp.30.

Wu A.Y.Y., Ooi C.G.C., Lam B., Mok T.Y.M., Ho P.L., Chan M.M.W., Ip M.S.M., Lam W.K. and Tsang K.W.T., The use of pentaglobin in patients with deteriorating severe acute respiratory syndrome, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia . 2003, Abstract Book PP6-15: p.194.

Researcher : Chan OO

List of Research Outputs

Chan O.O., Ng I.O.L., Lam C.M., Shek T.W.H. and Lai C.L., Cholestatic jaundice caused by sequential carbimazole and propylthiouracil treatment for thyrotoxicosis, Hong Kong Medical Journal. 2003, 9(5): 377-380.

Chan O.O., Yuen M.F., Lam C.M., Fong C.Y., Wong B.C.Y. and Lai C.L., Prevalence and Characteristics of Familial Hepatocellular Carcinoma Caused by Chronic Hepatitis B Infection in Hong Kong, Alimentary Pharmacology and Therapeutics. 2004, 19(4): 401-6.

Chan O.O., Wong W.M., Lam S.K. and Wong B.C.Y., Prevention of Gastric Cancer, Chinese Journal of Digestive Diseases. 2003, 4: 100-104.

Chan O.O., Peng J., Lam S.K., Hui W.M., Wong R.W.M., Yuen M.F., Kwong Y.L., Rashid A. and Wong B.C.Y., Reveral of E-Cadherin Promoter Hypermethylation Status after Helicobacter pylori Eradication, Gastroenterology. 2004, 126 (4 Suppl 2): 333.

Hui C.K., Liu C.L., Lai K.C., Chan S.C., Hu H.C., Wong R.W.M., Cheung W.W., Ng M.M.T., Yuen M.F., Chan O.O., Lo C.M., Fan S.T. and Wong B.C.Y., Outcome of emergency ERCP for acute cholangitis in patients 90 years of age and older, Alimentary Pharmacology and Therapeutics. 2004, 19(11): 1153-1158.

Hui C.K., Lai K.C., Yuen M.F., Wong R.W.M., Chan O.O., Ng M.M.T., Chan C.K., Cheung W.W., Lam S.K., Lai C.L. and Wong B.C.Y., The Role of Cholecystectomy in Reducing Recurrent Gallstone Pancreatitis, Endoscopy. 2004, 36(3): 206-11.

Lai K.C., Lam S.K., Chu K.M., Hui W.M., Kwok K.F., Wong B.C.Y., Hu H.C., Wong R.W.M., Chan O.O. and Chan C.K., Lansoprazole Reduces Ulcer Relapse after Eradication of Helicobacter pylori in Nonsteroidal Anti-Inflammatory Drug Users--a Randomized Trial, Alimentary Pharmacology and Therapeutics. 2003, 18(8): 829-36.

Lam C.M., Chan O.O., Ho P., Ng I.O.L., Lo C.M., Liu C.L., Poon R.T.P. and Fan S.T., Different presentation of hepatitis B-related hepatocellular carcinoma in a cohort of 1863 young and old patients - implications for screening, Alimentary Pharmacology and Therapeutics. 2004, 19(7): 771-777.

Preston S.L., Wong W.M., Chan O.O., Poulsom R., Jeffrey R., Goodlad R.A., Mandir N., Elia G., Novelli M., Bodmer W.F., Tomlinson I.P. and Wright N., Bottom-up Histogenesis of Colorectal Adenomas: Origin in the Monocryptal Adenoma and Initial Expansion by Crypt Fission, Cancer Research. 2003, 63: 3819-25.

Tu S., Chan O.O., Lin M.C., Jiang X., Lam S.K., Kung H. and Wong B.C.Y., Livin, a Novel Member of Inhibitor of Apoptosis, Is Marker of Poor Prognosis in Gastric Cancer, Gastroenterology. 2004, 126 (4 Suppl 2): T1256.

Tu S., Jiang X., Lin M.C., Cui J., Yang Y., Lum C.T., Zou B., Zhu Y.B., Jiang S.H., Wong W.M., Chan O.O., Yuen M.F., Lam S.K., Kung H. and Wong B.C.Y., Suppression of Survivin Expression Inhibits in vivo Tumorigenicity and Angiogenesis in Gastric Cancer, Cancer Research. 2003, 63(22): 7724-7732.

Wong R.W.M., Lai K.C., Hui W.M., Lam K.F., Huang J., Hu H.C., Wong Y.H., Lam C.L.K., Xia H.H.X., Chan O.O., Lam S.K. and Wong B.C.Y., Double-blind, Randomized Controlled Study to Assess the Effects of Lansoprazole 30 mg and Lansoprazole 15 mg on 24-h Oesophageal and Intragastric pH in Chinese Subjects with Gastro-Oesophageal Reflux Disease, Alimentary Pharmacology and Therapeutics. 2004, 19(4): 455-62.

Wong R.W.M., Lai K.C., Hui W.M., Hu H.C., Huang J., Wong Y.H., Xia H.H.X., Chan O.O., Lam S.K. and Wong B.C.Y., Pathophysiology of Gastro-oesophageal Reflux Diseases in Chinese – Role of Transient Lower Oesophageal Sphincter Relaxation and Oesophageal Motor Dysfunction, Gastroenterology. 2004, 126 (4 Suppl 2): T1724.

Wong R.W.M., Lam K.F., Cheng C., Hui W.M., Xia H.H.X., Lai K.C., Hu H.C., Huang J., Lam C.L.K., Chan C.K., Chan O.O., Lam S.K. and Wong B.C.Y., Population Based Study of Noncardiac Chest Pain in Southern Chinese: Prevalence, Psychosocial Factors and Health Care Utilization, World Journal of Gastroenterology. 2004, 10(5): 707-712.

Wong W.M., Lam S.K., Tong S.M., Cheung K.L., Tang V.S.Y., Xia H.H.X., Lai K.C., Hu H.C., Chan C.K., Yuen M.F., Chan O.O. and Wong B.C.Y., Evaluation of a Rapid Stool Antigen Test for the Diagnosis of Helicobacter pylori Infection in Chinese Patients, Chinese Journal of Digestive Diseases. 2003, 4: 132-135.

Yuen M.F., Kato T., Mizokami M., Chan O.O., Yuen J.C.H., Yuan H., Wong D.K.H., Sum S.M., Ng I.O.L., Fan S.T. and Lai C.L., Clinical outcome and virologic profiles of severe hepatitis B exacerbation due to YMDD mutations, Journal of Hepatology. 2003, 39(5): 850-855.

Yuen M.F., Wong D.K.H., Sablon E., Yuan H., Sum S.M., Hui C.K., Chan O.O., Wong B.C.Y. and Lai C.L., Hepatitis B Virus Genotypes B and C Do Not Affect The Antiviral Response To Lamivudine, Antiviral Therapy. 2003, 8: 531-534.

Yuen M.F., Sablon E., Wong K.H.D., Yuan H., Wong B.C.Y., Chan O.O. and Lai C.L., Role of Hepatitis B Virus Genotypes in Chronic Hepatitis B Exacerbation, Clinical Infectious Diseases. 2003, 37: 593-7.

Researcher : Chan PS

List of Research Outputs

Chan P.S., Shen J., Fung P.C.W. and Cheung R.T.F., Overproduction of nitric oxide from neuronal nitric oxide synthase during ischemia is partly mediated via activation of neuropeptide Y Y1 receptors, Neurology. 2004, 62(Suppl 5): A144.

Chan P.S., Shen J., Fung P.C.W. and Cheung R.T.F., Overproduction of nitric oxide from neuronal nitric oxide synthase during ischemia is partly mediated via activation of neuropeptide Y-Y1 receptors, 9th Medical Research Conference. 2004.

Researcher : Chan RHW

List of Research Outputs

Chan M.M.W., Lam W.K., Mak J.C.W., Ho S.P., Chan R.H.W., Tsang K.W.T., Ip M.S.M., Ho J.C.M., Wong M.P. and Tan-Un K.C., Polymorphisms of CYP and GST genes, passive smoke and lung cancer risk in Hong Kong Chinese, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-11.

Researcher : Chan TK

List of Research Outputs

Chan K., Wong M.S., Chan T.K. and Chan V.N.Y., A Thalassaemia Array For Southeast Asia, British Journal of Haematology. 2004, 124: 232-239.

Chan V.N.Y., Au P., Yip P.C. and Chan T.K., A New Cross-over Region For Hemoglobin-Lepore-Hollandia, Haematologica. 2004, 89: 610-611.

Researcher : Chan VNY

Project Title:	Development of a microarray based assay to study epigenomic alternation in breast cancer using comparative methylation hybridization
Investigator(s):	Prof. Chan V.N.Y., Dr. Chow L.W.C., Dr. Lee S.M.Y.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2002

Abstract:

To make use of the microarray techology to develop an assay that will generate the methylation profile of breast tumours that can be used for either diagnostic or prognostic evaluation in clinics.

Project Title:	Localisation of the disease or disease-susceptibility gene for adolescent idiopathic scoliosis
Investigator(s):	Prof. Chan V.N.Y., Dr. Chan K.M., Dr. Lee S.M.Y., Prof. Luk K.D.K.
Department:	Medicine
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	11/2003

Abstract:

To identify genes along the mouse chromosome 17 (which is in synteny to human chromosome 19p), that are expressed in tissues associated with AIS phenotype, such as muscle, bone, cartilage, tendon, etc; to identify by differential gene expression analysis those genes along human chromosome 19p13, expressed (differently- decreased or increased) in AIS patients compared to human control subjects; to sequence those genes of interest in genomic DNA of the indexed patients in the relevant AIS families, in order to identify the causative mutations.

Project Title:	Localisation of the disease or disease-susceptibility gene for adolescent idiopathic scoliosis
Investigator(s):	Prof. Chan V.N.Y., Dr. Chan K.M., Dr. Lee S.M.Y., Prof. Luk K.D.K.
Department:	Medicine
Source(s) of Funding:	RGC Projects (Block Grant Funded)
Start Date:	11/2003

Abstract:

List of Research Outputs

Chan K., Wong M.S., Chan T.K. and Chan V.N.Y., A Thalassaemia Array For Southeast Asia, British Journal of Haematology. 2004, 124: 232-239.

Chan V.N.Y., Au P., Yip P.C. and Chan T.K., A New Cross-over Region For Hemoglobin-Lepore-Hollandia, Haematologica. 2004, 89: 610-611.

Chan V.N.Y., Advances In The Diagnosis Of Common Genetic Diseases, Invited Speaker at the Frontiers in Biomedical Research, HKU. 2003.

Chan V.N.Y., Chairman of Symposium on Thalassaemia, 11th Asian Congress of Pediatrics and 1st Asian Congress on Pediatric Nursing, Thailand. 2003.

Chan V.N.Y., Guidelines of Antenatal Thalassaemia Screening, Hong Kong College of Obstetrics & Gynaecology Guidelines No. 8. 2003.

Chan V.N.Y., Innovative Technologies In Diagnosis And Treatment Of Thalassemia, Li Po Chun Charitable Trust Fund. 2003.

Chan V.N.Y., Member of International Advisory Board, XIXth International Congress of the International Society of Thrombosis & Haemostasis, United Kingdom. 2003.

Chan V.N.Y., Molecular Mechanism And Diagnosis Of a And b Thalassemias In Asia, Symposium Speaker, 11th Asian Congress of Pediatrics and 1st Asian Congress on Pediatric Nursing, Thailand. 2003.

Chan V.N.Y., Molecular Pathology And Diagnosis Of Thalassemias, Symposium Speaker at the Sixth Chinese Laboratory Medicine Conference, Hong Kong. 2003.

Chan V.N.Y., Preimplantation Diagnosis of Homozygous a^o Thalassemia, International Seminar on Preimplantation HLA Typing & Stem-Cell Transplantation, Limassole, Cyprus. 2004.

Chan V.N.Y., Reviewer, British Journal of Haematology. 2003.

Chan V.N.Y., Reviewer, International Journal of Haematology. 2003.

Chan V.N.Y., Thalassemia: Diagnosis To Treatment, Inaugural Meeting of the Hong Kong Society for Study of Thalassemia. 2004.

Kung A.W.C., Lau K.S. and Chan V.N.Y., Association of a novel single nucleotide polymorphism in the calcium channel a subunit gene (Cav1.1) and thyrotoxic periodic paralysis, Journal of Clinical Endocrinology & Metabolism. 2004, 89(3): 1340-5.

Kung A.W.C., Ng M.Y.M., Lau H.L., Paterson A.D., Bulman D., Luk K.D.K. and Chan V.N.Y., Association of low bone mineral density to microsatellite marker on chromosome 16 in Southern Chinese families, 4th International Meeting on the Genetic Epidemiology of complex Traits, 4-7 April 2004, Churchill College, Cambridge, UK. 2004.

Kung A.W.C., Lau K.S., Fong C.Y. and Chan V.N.Y., Association of novel single-nucleotide polymorphisms in the dihydropyridine sensitive L-type a-3 calcium channel (CACNL1a3) and thyrotoxic periodic paralysis (TPP) , American thyroid Association 75th Annual Meeting, 16-21 September 2003, Palm Beach, USA. Thyroid. 2003, 13(7): 672.

Xu J., Dan Q., Chan V.N.Y., Wat N.M.S., Tam S.C.F., Tiu S.C., Lee K.F., Siu S.C., Tsang M.W., Fung L.M., Chan K.W. and Lam K.S.L., Genetic and clinical characteristics of maturity-onset diabetes of the young in Chinese patient, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Researcher : Chan WK

List of Research Outputs

Jin O., Chan W.K., Mok T.M.Y., Sun L.Y. and Lau W.C.S., Serum levels of osteopontin and matrix metalloproteinase-3 in systemic lupus erythematosus (SLE), 7th International Congress on SLE & Related Conditions, New York. 2004.

Kumar S., Lau W.C.S., Chan W.K., Yang D., Cheung H.Y., Chen F. and Hyde K.D., Immunomodulatory activity of an endophytic fungus isolated from Tripterygium wilfordii, 2nd International Conference on Medicinal Mushroom and the International Conference on Biodiversity and Bioactive Compounds. 2003, 367-373.

Mok T.M.Y., Yeung J.S.L., Jin O., Chan W.K., Lo Y. and Lau W.C.S., Anti-beta2 glycoprotein I antibodies facilitates phagocytosis of apoptotic neutrophils in patients with systemic lupus erythematosus, The Hong Kong Practitioner. 2003, 9(Suppl 1): 65.

Mok T.M.Y., Yeung J.S.L., Chan W.K., Leung P.Y., Lo Y. and Lau W.C.S., Sex hormones and apoptosis and immunoglobulin production in systemic lupus erythematosus, The Hong Kong Practitioner. 2003, 9(Suppl 1): 66.

Ren Y., Tang J.L., Mok T.M.Y., Chan W.K., Wu A.Y.Y. and Lau W.C.S., Increased apoptotic neutrophils and macrophages and impaired macrophage phagocytic clearance of apoptotic neutrophils in systemic lupus erythematosus, Arthritis & Rheumatism. 2003, 48: 2888-97.

Xu A., Yiu S., Wong L.Y.F., Chan W.K. and Lam K.S.L., The fat-derived hormone adiponectin ameliorates dyslipidemia induced by HIV protease inhibitors, XIII International Symposium on Atherosclerosis, September 28-October 2, 2003, Kyoto, Japan . The European Atherosclerosis Society, 2003, Sep 2003: 242 (3P-0821*).

Researcher : Chan YL

List of Research Outputs

Lam T.P., Cheng Y.H. and Chan Y.L., Low literacy Chinese patients: how do they cope? A qualitative study, BioMed Central Public Health. 2004, 4: 14.

Researcher : Chang PCM

List of Research Outputs

Ng F.H., Wong B.C.Y., Wong S.Y., Chen W.H. and Chang P.C.M., Clopidogrel plus Omeprazole Compared with Aspirin plus Omeprazole for Aspirin-Induced Symptomatic Peptic Ulcers/Erosions with Low to Moderate Bleeding/Re-Bleeding Risk -- a Single-Blind, Randomized Controlled Study, Alimentary Pharmacology and Therapeutics. 2004, 19(3): 359-65.

Ng F.H., Wong S.Y., Chang P.C.M., Chen W.H., Kng N., Lanas A.I. and Wong B.C.Y., High Incidence of Clopidogrel-Associated Gastrointestinal Bleeding in Patients with Previous Peptic Ulcer Disease, Alimentary Pharmacology and Therapeutics. 2003, 18(4): 443-9.

Researcher : Chau FY

List of Research Outputs

Cheung B.M.Y., Lam T.H., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Man Y.B., Cheng C.H., Kumana C.R. and Lau C.P., Follow Up of the Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort (CP17), Seventh Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine: Journal of the Hong Kong College of Cardiology . 2003, 11 (Suppl 1).

Cheung B.M.Y., Lam T.H., Lam K.S.L., Tam S.C.F., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Man Y.B., Cheng C.H., Kumana C.R. and Lau C.P., Follow up of the Hong Kong Cardiovascular risk factor prevalence survey cohort, Hong Kong Medical Journal. 2003, 9(1) Suppl: 27.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., High blood pressure is related to obesity in Hong Kong, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., High blood pressure is related to obesity in Hong Kong, Hong Kong Medical Journal. 2003, 9(1) Suppl: 35.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Lipid profile of the Hong Kong cardiovascular risk factor prevalence study cohort, Hong Kong Medical Journal. 2003, 9(1) Suppl: 22.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Obesity in the Hong Kong cardiovascular risk factor prevalence survey-2 (CRISPS2) cohort, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Cheung B.M.Y., Man Y.B., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of Diabetes Mellitus (DM) in the Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort (P16), Seventh Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine: Journal of the Hong Kong College of Cardiology . 2003, 11 (Suppl 1).

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of diabetes mellitus (DM) in the Hong Kong Cardiovascular risk factor prevalence study cohort, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Cheung B.M.Y., Man Y.B., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of diabetes mellitus (DM) in the Hong Kong Cardiovascular risk factor prevalence study cohort, Hong Kong Medical Journal. 2003, 9(1) Suppl: 19.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of obesity in the Hong Kong Cardiovascular risk factor prevalence survey-2 (CRISPS2), Hong Kong Medical Journal. 2003, 9(1) Suppl: 23.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Relationship between Hypertension and Obesity in Hong Kong, 3rd Asian-Pacific Congress of Hypertension. 2004.

Man Y.B., Cheung B.M.Y., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of hypertension in the Hong Kong cardiovascular risk factor prevalence study cohort, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Researcher : Chen WH

Project Title:	A randomized placebo-controlled trial to test whether abciximab can reduce in-stent restonosis in diabetic patients after intra coronary stenting
Investigator(s):	Dr. Chen W.H., Dr. Lau Y.K., Prof. Lau C.P., Dr. Leung W.S.
Department:	Medicine
Source(s) of Funding:	Eli Lilly Asia Inc.
Start Date:	01/2001

Abstract:

To investigate whether abciximab can reduce in-stent restenosis in diabetic patients after intra coronary stenting.

Project Title:	A randomized placebo-controlled trial to test whether abciximab can reduce in-stent restonosis in diabetic patients after intra coronary stenting
Investigator(s):	Dr. Chen W.H., Dr. Lau Y.K., Prof. Lau C.P., Dr. Leung W.S.
Department:	Medicine
Source(s) of Funding:	Guidant Hong Kong Ltd.
Start Date:	01/2001

Abstract:

To investigate whether abciximab can reduce in-stent restenosis in diabetic patients after intra coronary stenting.

Project Title:	A prospective study to investigate the determinants of the quantity of embolized debris during native vessel percutaneous coronary intervention
Investigator(s):	Dr. Chen W.H., Prof. Lau C.P.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2002

Abstract:

To identity the clinical and lesion characteristics that determine the quantity of embolized debris captured by a distal protection device during native vessel PCI.

Project Title:	A prospective study to evaluate the relation between aspirin resistance and the incidence and magnitude of myonecrosis after percutaneous coronary intervention
Investigator(s):	Dr. Chen W.H., Prof. Lau C.P.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2003

Abstract:

To compare the incidence and magnitude of myoecrosis between aspirin-sensitive and -resistant patients undergoing PCI.

List of Research Outputs

Chen W.H. and Lau C.P., Advances in antithrombin therapy for ST-elevation myocardiac infarction, Chin Med J (Engl)2003. 2003, 116(11): 1760-3. Review.

Chen W.H., Tse H.F., Lau C.P., Lee P.Y. and Ng W., Aspirin resistance is associated with a high incidence of myonecrosis after non-urgent percutaneous coronary intervention despite clopidogrel pretreatment, J Am Coll Cardiol . 2004, 43(6): 1122-6.

Chen W.H., Lau C.P., Lee P.Y. and Ng W., Percutaneous recanalization of chronic subclavian artery occlusion using optical coherence reflectometry-guided radiofrequency ablation guidewire, Catheter Cardiovasc Interv 2003 Dec. 2003, 60(4): 558-61.

Chen W.H., Lau C.P., Lee P.Y. and Ng W., Safety and feasibility of the use of a distal filter protection device in percutaneous revascularization of small coronary arteries, Catheter Cardiovasc Interv 2004. 2004, 61(3): 360-3.

Lee P.Y., Ng W. and Chen W.H., Concomitant coronary and subclavian steal caused by ipsilateral subclavian artery stenosis and arteriovenous fistula in a hemodialysis patient., Catheter Cardiovasc Interv . 2004, 62(2): 244-8.

Ng F.H., Wong B.C.Y., Wong S.Y., Chen W.H. and Chang P.C.M., Clopidogrel plus Omeprazole Compared with Aspirin plus Omeprazole for Aspirin-Induced Symptomatic Peptic Ulcers/Erosions with Low to Moderate Bleeding/Re-Bleeding Risk -- a Single-Blind, Randomized Controlled Study, Alimentary Pharmacology and Therapeutics. 2004, 19(3): 359-65.

Ng F.H., Wong S.Y., Chang P.C.M., Chen W.H., Kng N., Lanas A.I. and Wong B.C.Y., High Incidence of Clopidogrel-Associated Gastrointestinal Bleeding in Patients with Previous Peptic Ulcer Disease, Alimentary Pharmacology and Therapeutics. 2003, 18(4): 443-9.

Ng W., Chen W.H., Lee P.Y. and Lau C.P., Initial experience and safety in the treatment of chronic total coronary occlusions with a new optical coherent reflectometry-guided radiofreqency ablation guideline., Am J Cardiol.. 2003, 92 (6): 732-4.

Tse H.F., Thambar S., Kwong Y.L., Chen W.H., Lau C.P., Chan J.K.F., Lo G., Lai C.L. and Bellan G., Long-Term clinical outcome of catheter-based intramyocardial autologous bone marrow cells implanation in patients with end-stage coronary artery disease, J Am Coll Cardiol. 2004, 43: 39A.

Researcher : Chen X (Chen Xuehua)

List of Research Outputs

Tang S.C.W., Leung J.C.K., Chan L.Y., Tsang W.L., Chen X., Zhou W., Lai K.N. and Sacks S.H., Regulation of complement C3 and C4 synthesis in human peritoneal mesothelial cells by peritoneal dialysis fluid, Clinical & Experimental Immunology. 2004, 136: 85-94.

Researcher : Chen X (Chen Xiaorui)

List of Research Outputs

Yung S.S.Y., Chen X., Tsang R.C.W., Zhang Q. and Chan D.T.M., Reduction of perlecan synthesis and induction of TGF-beta 1 in human peritoneal mesothelial cells due to high glucose concentration - implication in peritoneal dialysis, Journal of American Society of Nephrology. 2004, May 15 (5): 1178-1188.

Researcher : Cheng C

List of Research Outputs

Cheng C., Chan O.O., Hui W.M. and Lam S.K., Coping Strategies, Illness Perception, Anxiety and Depression of Patients with Idiopathic Constipation: a Population-Based Study, Alimentary Pharmacology and Therapeutics. 2003, 18(3): 319-26.

Wong R.W.M., Cheng C. and Wong B.C.Y., Constipation, Medical Progress. 2004, 31(4): 201-207.

Wong R.W.M., Cheng C., Hui W.M. and Wong B.C.Y., Irritable Bowel Syndrome, Medical Progress. 2003, 30(8): 50-55.

Wong R.W.M., Lam K.F., Cheng C., Hui W.M., Xia H.H.X., Lai K.C., Hu H.C., Huang J., Lam C.L.K., Chan C.K., Chan O.O., Lam S.K. and Wong B.C.Y., Population Based Study of Noncardiac Chest Pain in Southern Chinese: Prevalence, Psychosocial Factors and Health Care Utilization, World Journal of Gastroenterology. 2004, 10(5): 707-712.

Researcher : Cheng CH

List of Research Outputs

Cheung B.M.Y., Lam T.H., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Man Y.B., Cheng C.H., Kumana C.R. and Lau C.P., Follow Up of the Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort (CP17), Seventh Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine: Journal of the Hong Kong College of Cardiology . 2003, 11 (Suppl 1).

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., High blood pressure is related to obesity in Hong Kong, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Lipid profile of the Hong Kong cardiovascular risk factor prevalence study cohort, Hong Kong Medical Journal. 2003, 9(1) Suppl: 22.

Cheung B.M.Y., Man Y.B., Lam K.S.L., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Lipid profile of the Hong Kong cardiovascular risk factor prevalence survey cohort, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Obesity in the Hong Kong cardiovascular risk factor prevalence survey-2 (CRISPS2) cohort, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Cheung B.M.Y., Man Y.B., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of Diabetes Mellitus (DM) in the Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort (P16), Seventh Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine: Journal of the Hong Kong College of Cardiology . 2003, 11 (Suppl 1).

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of diabetes mellitus (DM) in the Hong Kong Cardiovascular risk factor prevalence study cohort, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Cheung B.M.Y., Man Y.B., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of diabetes mellitus (DM) in the Hong Kong Cardiovascular risk factor prevalence study cohort, Hong Kong Medical Journal. 2003, 9(1) Suppl: 19.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of obesity in the Hong Kong Cardiovascular risk factor prevalence survey-2 (CRISPS2), Hong Kong Medical Journal. 2003, 9(1) Suppl: 23.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Relationship between Hypertension and Obesity in Hong Kong, 3rd Asian-Pacific Congress of Hypertension. 2004.

Man Y.B., Cheung B.M.Y., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of hypertension in the Hong Kong cardiovascular risk factor prevalence study cohort, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Researcher : Cheng IKP

List of Research Outputs

Tang S.C.W., Lui S.L., Lo C.Y., Lo W.K., Cheng I.K.P., Lai K.N. and Chan D.T.M., Spousal renal donor transplantation in Chinese subjects: a 10 year experience from a single centre, Nephrology Dialysis Transplantation. 2004, 19: 203-206.

Tang S.C.W., Cheng I.K.P., Leung V.K.S., Kuok U.I., Tang A.W.C., Ho Y.W., Lai K.N. and Chan D.T.M., Successful treatment of hepatitis C after kidney transplantation with combined interferon alpha-2b and ribavirin, Journal of Hepatology. 2003, 39: 875-878.

Researcher : Cheng KY

List of Research Outputs

Dan Q., Xu A., Cheng K.Y., Xu J. and Lam K.S.L., Adiponectin suppresses the proliferation of human aortic smooth muscle cells induced by advanced glycation and end products, The 3rd International Huaxia Congress of Endocrinology, May 25 – 28, 2004, Shanghai, China. 2004.

Dan Q., Wong L.C., Cheng K.Y., Chung S.S.M., Chung S.K. and Lam K.S.L., The polyol pathway and diabetic atherosclerosis, The 3rd International Huaxia Congress of Endocrinology, May 25 – 28, 2004, Shanghai, China. 2004.

Tao A.W.K., Wat N.M.S., Xu A., Rong R., Cheng K.Y., Fong H.Y., Janus E.D. and Lam K.S.L., The adiponectin gene T45G polymorphism is associated with central obesity and glucose intolerance in southern Chinese, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Researcher : Cheung BMY

Project Title:	The role of adrenomedullin in inflammation
Investigator(s):	Dr. Cheung B.M.Y., Dr. Lan H.Y., Prof. Lau W.C.S., Prof. Tang F., Dr. Tsang K.W.T.
Department:	Medicine
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	10/2000

Abstract:

To investigate whether human adrenomedullin (AM) is an inflammatory or anti-inflammatory cytokine in vitro and in vivo. For patients with systemic lupus erythematosus (SLE), the project will study the changes in AM level during relapses and remissions, and after immunosuppressive therapy. The research will lead to new strategies to treat systemic inflammatory conditions, and pave way for the development of anti-inflammatory and immunosuppressive agents with fewer adverse effects.

Project Title:	Hong Kong cardiovascular risk factor prevalence study-2 (CRISPS-2)
Investigator(s):	Dr. Cheung B.M.Y., Dr. Cheng C.H., Prof. Lam K.S.L., Prof. Lam T.H., Prof. Lau C.P., Prof. Tam S.C.F., Dr. Wat N.M.S.
Department:	Medicine
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	10/2001

Abstract:

To determine the cumulative incidence of hypertension and diabetes, which are risk factors for cardiovascular diseases, in the cohort of subjects recruited in the Hong Kong Cardiovascular Risk Factor Prevalence Study in 1995-6; to determine the incidence of cardiovascular and non-cardiovascular diseases since the Hong Kong Cardiovascular Risk Factor Prevalence Study in 1995-6; to analyse the baseline factors to see if they are predictors of hypertension and diabetes, and if so, to quantify the risk and to study their interactions; to measure changes in baseline risk factors, which may have important consequences on public health.

Project Title:	Hypertension genes in Hong Kong Chinese
Investigator(s):	Dr. Cheung B.M.Y., Prof. Lau C.P.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2001

Abstract:

To study several new candidate genes that have been identified in whole genome search. By targeting specific candidate genes in our large bank of accurately defined hypertensive patients and normal controls, we can achieve high power in either confirming or refuting their association with hypertension in a Chinese population.

Project Title:	Advantages of blood pressure optimisation
Investigator(s):	Dr. Cheung B.M.Y., Prof. Lau C.P., Dr. Tse H.F.
Department:	Medicine
Source(s) of Funding:	RGC Projects (Block Grant Funded)
Start Date:	07/2003

Abstract:

To compare optimal blood pressure control with conventional blood pressure targets in hypertensive patients in terms of target organ damage and tolerability.

Project Title:	Does urotensin II, the most potent vasoconstrictor known, cause high blood pressure?
Investigator(s):	Dr. Cheung B.M.Y.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2003

Abstract:

To confirm that plasma urotensin II is raised in hypertension in man and to identify the factors leading to its elevation in vivo; to study the promoter region of the urotensin II gene, identify single nucleotide polymorphisms in Hong Kong Chinese and correlate these with plasma urotensin II level and blood pressure; to study in vitro, in a cell culture model, how the gene expression of urotensin II is altered by factors known to be important in hypetension.

List of Research Outputs

Ambekar C.S., Kumana C.R., Liang R.H.S. and Cheung B.M.Y., Chloramphenicol succinate as a competitive substrate and inhibitor of succinate dehydrogenase: relation to its mechanisms of toxicity, Hong Kong Medical Journal. 2003, 9(1) Suppl: 64.

Ambekar C.S., Lee J.S.K., Cheung B.M.Y., Chan L.C., Liang R.H.S. and Kumana C.R., Chloramphenicol succinate, a competitive substrate and inhibitor of succinate dehdrogenase : possible reason for its toxicity., Toxicology in Vitro. 2004, 18: 441-447.

Ambekar C.S., Kumana C.R., Liang R.H.S. and Cheung B.M.Y., Traditional Chinese medicine: effect on bone marrow and peripheral blood cell counts and enzyme induction, Hong Kong Medical Journal. 2003, 9(1) Suppl: 63.

Cheung B.M.Y., Wong L.Y.F., Li C.Y.Y., Hwang I.S.S. and Tang F., Adrenomedullin expression and cytokine response in experimentally induced endotoxaemia, Joint International Symposium on Calcitonin Gene-Related Peptide, Amylin and Calcitonin/4th Symposium on adrenomedullin and Proadrenomedullin N-20 Peptide. Zurich, Switzerland. 2004, P16.

Cheung B.M.Y., Wong L.Y.F., Li Y.Y., Hwang I.S.S. and Tang F., Adrenomedullin expression and cytokine response in experimentally induced endotoxaemia, Neuropeptides. 2004, 38: 126.

Cheung B.M.Y., Lau C.P. and Kumana C.R., Combination therapy for hypertension, Hong Kong Medical Journal. 2003, 9: 224-6.

Cheung B.M.Y., Ansari M.T., Fong D.Y.T., Thorburn J., Ma E.S.K. and Karlberg J.P.E., Earthworm extract as a fibrinolytic agent in healthy men: a randomised, double-blind, placebo-controlled study, Hong Kong Medical Journal. 2003, 9(1) Suppl: 22.

Cheung B.M.Y., Lo L.F., Chan S.K., Chan M.Y., Fong D.Y.T., Leung R.K.W., Wong S., Wong V., Lam K.S.L., Lau C.P., Lee P.W.H. and Karlberg J.P.E., Effect of qigong on hypertension: a randomised controlled study, Hong Kong Medical Journal. 2003, 9(1) Suppl: 21.

Cheung B.M.Y., Lauder I.J. and Kumana C.R., Effectiveness and Safety of Statins Reappraised: Updated Meta-Analysis with 5 New Trials (P17), Seventh Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine: Journal of the Hong Kong College of Cardiology. 2003, 11 (Suppl 1).

Cheung B.M.Y. and Kumana C.R., Effectiveness of lipid lowering drugs in general practice: study had two major flaws, British Medical Journal. London, BMJ Publishing Group, 2003, 347(7405): 51.

Cheung B.M.Y., Lam T.H., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Man Y.B., Cheng C.H., Kumana C.R. and Lau C.P., Follow Up of the Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort (CP17), Seventh Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine: Journal of the Hong Kong College of Cardiology . 2003, 11 (Suppl 1).

Cheung B.M.Y., Lam T.H., Lam K.S.L., Tam S.C.F., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Man Y.B., Cheng C.H., Kumana C.R. and Lau C.P., Follow up of the Hong Kong Cardiovascular risk factor prevalence survey cohort, Hong Kong Medical Journal. 2003, 9(1) Suppl: 27.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., High blood pressure is related to obesity in Hong Kong, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., High blood pressure is related to obesity in Hong Kong, Hong Kong Medical Journal. 2003, 9(1) Suppl: 35.

Cheung B.M.Y., Hwang I.S.S., Li Y.Y., O W.S., Tsang K.W.T., Leung Y.H., Kumana C.R. and Tang F., Increased adrenomedullin expression in lungs in endotoxaemia, Journal of Endocrinology. Bristol, Society for Endocrinology, 2004, 181(2): 339-345.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Lipid profile of the Hong Kong cardiovascular risk factor prevalence study cohort, Hong Kong Medical Journal. 2003, 9(1) Suppl: 22.

Cheung B.M.Y., Man Y.B., Lam K.S.L., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Lipid profile of the Hong Kong cardiovascular risk factor prevalence survey cohort, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Cheung B.M.Y., Lauder I.J., Lau C.P. and Kumana C.R., Meta-analysis of large randomized controlled trials to evaluate the impact of statins on cardiovascular outcomes, British Journal of Clinical Pharmacology. Blackwell Publishing, 2004, 57(5): 640-651.

Cheung B.M.Y. and Lau C.P., New opportunities and challenges in heart protection, Journal of Hong Kong College of Cardiology. 2003, 11: 1-3.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Obesity in the Hong Kong cardiovascular risk factor prevalence survey-2 (CRISPS2) cohort, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Cheung B.M.Y., Man Y.B., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of Diabetes Mellitus (DM) in the Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort (P16), Seventh Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine: Journal of the Hong Kong College of Cardiology . 2003, 11 (Suppl 1).

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of diabetes mellitus (DM) in the Hong Kong Cardiovascular risk factor prevalence study cohort, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Cheung B.M.Y., Man Y.B., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of diabetes mellitus (DM) in the Hong Kong Cardiovascular risk factor prevalence study cohort, Hong Kong Medical Journal. 2003, 9(1) Suppl: 19.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of obesity in the Hong Kong Cardiovascular risk factor prevalence survey-2 (CRISPS2), Hong Kong Medical Journal. 2003, 9(1) Suppl: 23.

Cheung B.M.Y., Law C.Y., Ho G.Y.Y., Ng P.P.Y., Kumana C.R. and Lau C.P., Randomised Controlled Trial of Low Salt Diet in the Treatment of Hypertension (P-229), In: FC Tuluney, M Orme, Sixth Congress of European Association of Clinical Pharmacology adn Therapeutics - European Collaboration: Towards Drug Development and Rational Drug Therapy. 2003, 132.

Cheung B.M.Y., Law C.Y., Fung P.C.W., Tsang K.W.T., Tan K.C.B., Kumana C.R. and Lau C.P., Randomised Trial of Candesartan and Enalapril (RACE) in the treatment of hypertension (P-215), In: FC Tuluney, M Orme, Sixth Congress of European Association of Clinical Pharmacology adn Therapeutics - European Collaboration: Towards Drug Development and Rational Drug Therapy . 2003, 128.

Cheung B.M.Y., Law C.Y., Ho G.Y.Y., Ng P.P.Y., Kumana C.R. and Lau C.P., Randomised controlled trial of low salt diet in the treatment of hypertension, Hong Kong Medical Journal. 2003, 9(1) Suppl: 23.

Cheung B.M.Y., Law C.Y., Fung P.C.W., Tsang K.W.T., Tan K.C.B., Kumana C.R. and Lau C.P., Randomised trial of candesartan and enalapril (RACE) in the treatment of hypertension-final results, Hong Kong Medical Journal. 2003, 9(1) Suppl: 24.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Relationship between Hypertension and Obesity in Hong Kong, 3rd Asian-Pacific Congress of Hypertension. 2004.

Cheung B.M.Y., Wong L.Y.F., Li Y.Y. and Tang F., The cytokine response of rat macrophages to lipopolysaccharide is modulated by adrenomedullin, Hong Kong Medical Journal. 2003, 9(1) Suppl: 26.

Cheung B.M.Y., The renin-angiotensin system, Doctor. 2003, 4(1): 8-9.

Cheung B.M.Y., Leung Y.H., Wong L.Y.F., Man Y.B., Lau C.P. and Kumana C.R., Urotensin II in hypertension, Hong Kong Medical Journal. 2003, 9(1) Suppl: 24.

Kumana C.R., Cheung B.M.Y. and Lauder I.J., Rhythm Control for Atrial Fibrillation Reanalysed by NNT, 8th International Workshop on Cardiac Arrhythmias . 2003.

Kumana C.R., Cheung B.M.Y. and Lauder I.J., The burden of rate control in atrial fibrillation, Journal of Cardiovascular Pharmacology and Therapeutics. 2003, 8(3): 247-248.

Kuong Y.L., Woo Y.M., Kou K.O., Lai K.W., Leow P.L., Tam P.K., Tse K.S., Tung Y.L., Lee K., Irwin M.G., Chau Y.K. and Cheung B.M.Y., Public knowledge in Hong Kong towards cardiopulmonary resuscitation, Hong Kong Medical Journal. 2003, 9(1) Suppl: 25.

Lam T.C., Cheung B.M.Y., Ko B.C.K., Chung S.S.M. and Lau C.P., Genetic linkage of beta and gamma subunits of epithelial sodium channel to systolic blood pressure in southern Chinese, Hong Kong Medical Journal. 2003, 9(1) Suppl: 25.

Li Y.Y., Tang F. and Cheung B.M.Y., Endotoxin increases adrenomedullin expression in heart, lung and mesenteric artery, Hong Kong Medical Journal. 2003, 9(1) Suppl: 30.

Li Y.Y., Tang F. and Cheung B.M.Y., Increased adrenomedullin expression in the heart, the lung and the mesenteric artery by endotoxin, Hong Medical Journal. 2003, 9(1) Suppl: 26.

Man Y.B., Cheung B.M.Y., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of hypertension in the Hong Kong cardiovascular risk factor prevalence study cohort, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Pederson B., Cheung B.M.Y., Lauder I.J. and Kumana C.R., Rhythm Control of Atrial Fibrillation Analysed by Number Needed to Treat (P19), Seventh Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine: Journal of the Hong Kong College of Cardiology . 2003, 11 (Suppl 1).

Rong R., Tao A.W.K., Xu A., Cheung G.C.N., Yeung C., Cheung B.M.Y. and Lam K.S.L., Hypoadiponectinaemia is a risk factor of the metabolic syndrome, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Rong R., Xu A., Cheung B.M.Y., Cheung G.C.N. and Lam K.S.L., Identification of three novel missense mutations of the human melanocortin-4 receptor gene in a Chinese obesity population, ENDO 2004, New Orleans, USA, 16-19 June 2004.

Wong L.Y.F., Cheung B.M.Y., Li Y.Y. and Tang F., Adrenomedullin expression and its effects on cytokine response of rat macrophages to lipopolysaccharide, Neuropeptides. 2004, 38: 117.

Wong L.Y.F., Cheung B.M.Y., Li C.Y.Y. and Tang F., Adrenomedullin expression and its effects on cytokine response of rat macrophages to lipopolysaccharides, Joint International Symposium on Calcitonin Gene-Related Peptide, Amylin and Calcitonin/4th Symposium on adrenomedullin and Proadrenomedullin N-20 Peptide. Zurich, Switzerland. 2004, S20.

Wong L.Y.F., Cheung B.M.Y., Li Y.Y. and Tang F., Adrenomedullin suppresses MIF production and cytokine response of rat macrophages to lipopolysaccharide, Journal of Hong Kong College of Cardiology. 2003, 11(Suppl 1): A17.

Wong L.Y.F., Cheung B.M.Y., Li Y.Y., Tang F. and Lan H.Y., Adrenomedullin suppresses migration inhibitory factor production and cytokine response of rat macrophages to lipopolysaccharide, Hong Kong Medical Journal. 2003, 9(1) Suppl: 29.

Wong L.Y.F., Cheung B.M.Y., Li C.Y.Y. and Tang F., The role of adrenomedullin in the cardiovascular system, Journal of Hong Kong College of Cardiology. 2004, 12: 1-7.

Researcher : Cheung GCN

List of Research Outputs

Rong R., Tao A.W.K., Xu A., Cheung G.C.N., Yeung C., Cheung B.M.Y. and Lam K.S.L., Hypoadiponectinaemia is a risk factor of the metabolic syndrome, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Rong R., Xu A., Cheung B.M.Y., Cheung G.C.N. and Lam K.S.L., Identification of three novel missense mutations of the human melanocortin-4 receptor gene in a Chinese obesity population, ENDO 2004, New Orleans, USA, 16-19 June 2004.

Researcher : Cheung GTY

List of Research Outputs

Cheung G.T.Y., Lau W.C.S. and Kumana C.R., Phosphodiesterase-5 inhibitors relieve symptoms of severe Raynaud's phenomenon, The European League Against Rheumatism (EULAR) Annual Congress for Rheumatology, Berlin, Germany. 2004.

Kumana C.R., Cheung G.T.Y., Lauder I.J. and Chan L.S., Screening for Fever by Means of Infrared Thermographic Camera (S110), 11th Ineternational Congress of infectious diseases – Mexico 2004: International Journal of Infectious Diseases. 2004, 8 (Suppl 1).

Researcher : Cheung KL

List of Research Outputs

Wong B.C.Y., Wong R.W.M., Cheung K.L., Tong S.M., Rozen P., Young G.P., Chu K.W., Ho J.W.C., Law W.L., Tung H.M., Lai K.C., Hu H.C., Chan C.K. and Lam S.K., A Sensitive Guaiac Fecal Occult Blood Test is Less Useful than an Immunochemical Test for Colorectal Cancer Screening in a Chinese Population , Alimentary Pharmacology and Therapeutics. 2003, 18(9): 941-946.

Wong W.M., Lam S.K., Tong S.M., Cheung K.L., Tang V.S.Y., Xia H.H.X., Lai K.C., Hu H.C., Chan C.K., Yuen M.F., Chan O.O. and Wong B.C.Y., Evaluation of a Rapid Stool Antigen Test for the Diagnosis of Helicobacter pylori Infection in Chinese Patients, Chinese Journal of Digestive Diseases. 2003, 4: 132-135.

Researcher : Cheung RTF

Project Title:	Further studies on neuroprotection of melatonin against focal cerebral ischaemia in rats
Investigator(s):	Dr. Cheung R.T.F.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2001
Completion Date:	10/2003

Abstract:

To examine the neuroprotective potential of melatonin in a rat middle cerebral artery occlusion (MCAO) stroke model.

Project Title:	Neuroprotective potential of neuropeptide Y-Y1 receptor inhibition
Investigator(s):	Dr. Cheung R.T.F.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2002
Completion Date:	10/2004

Abstract:

To explore the neuroprotective potential of NPY-Y1 receptor inhibition in both in vivo and in vitro stroke models.

Project Title:	Cognitive impairment and dementia among stroke patients in Hong Kong
Investigator(s):	Dr. Cheung R.T.F.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2003

Abstract:

To study: (1) the prevalence and risk factors of vascular cognitive impairment and dementia in Chinese stroke patients and (2) the incidence and risk factors of vascular cognitive impairment and dementia upon follow up of Chinese stroke patients without dementia during initial assessment.

List of Research Outputs

Bonovich D., Tsoi T.H. and Cheung R.T.F., Workshop VI: NIHSS training and certification, Hong Kong Stroke Symposium & Workshop. 2003.

Chan K.H., Cheung R.T.F., Mak W., Au Yeung K.M. and Ho S.L., Cerebral venous thrombosis presenting as unilateral headache plus visual blurring in a man with nephrotic syndrome, Hospital Medicine. 2004, 65: 54-55.

Chan K.H., Cheung R.T.F., Fong G.C.Y., Tsang K.L., Mak W. and Ho S.L., Clinical relevance of hydrocephalus as a presenting feature of tuberculous meningitis., Quarterly Journal of Medicine. . 2003, 96: 643-648.

Chan K.H., Mak W., Tsang K.L., Fong C.Y.G., Cheng T.S., Cheung R.T.F. and Ho S.L., Idiopathic relapsing transverse myelitis: experience of a regional hospital, 9th Medical Research Conference. 2004.

Chan K.H., Cheung R.T.F., Mak W., Fong C.Y.G., Tsang K.L., Cheng T.S. and Ho S.L., Predictive factors for ischemic strokes complicating tuberculous meningitis, Hong Kong Medical Journal. 2004, 10(Suppl 1): 34.

Chan K.H., Ho P.L., Cheung R.T.F., Tsang K.L., Fong G.C.Y., Cheng P.W. and Ho S.L., Tuberculous meningitis with tuberculomata presenting as postpartum pyrexia of unknown origin. , Hospital Medicine. 2003, 64: 306-307.

Chan P.S., Shen J., Fung P.C.W. and Cheung R.T.F., Overproduction of nitric oxide from neuronal nitric oxide synthase during ischemia is partly mediated via activation of neuropeptide Y Y1 receptors, Neurology. 2004, 62(Suppl 5): A144.

Chan P.S., Shen J., Fung P.C.W. and Cheung R.T.F., Overproduction of nitric oxide from neuronal nitric oxide synthase during ischemia is partly mediated via activation of neuropeptide Y-Y1 receptors, 9th Medical Research Conference. 2004.

Cheng T.S., Mak W., Fong C.Y.G., Chan K.H., Ho S.L. and Cheung R.T.F., Clinical relevance of severe initial hypertension in acute intracerebral haemorrhage, Hong Kong Medical Journal. 2004, 10(Suppl 1): 34.

Cheung R.T.F., Au Yeung K.M., Lee T.Y. and Chan K.H., A dynamic computed tomographic study of cerebral perfusion parameters in acute middle cerebral artery territory ischemic infarction, Neurology. 2004, 62(Suppl 5): A137.

Cheung R.T.F., Au Yeung K.M. and Lee T.Y., A dynamic computed tomographic study of cerebral perfusion parameters in subacute middle cerebral artery territory ischemic infarction, Cerebrovascular Diseases. 2004, 17(Suppl 5): 98.

Cheung R.T.F., Zou L., Cheng P.W. and Lee T.Y., A dynamic computed tomographic study of chronic ischemia in patients with unilateral or bilateral severe stenosis or unilateral moderate stenosis of the internal carotid artery, Cerebrovascular Diseases. 2004, 17(Suppl 5): 55.

Cheung R.T.F., Board Member, Specialty Board in Neurology, Hong Kong College of Physicians. 2004.

Cheung R.T.F., Board Member, Stroke Advisory Board. 2004.

Cheung R.T.F. and Hachinski V., Cardiac effects of stroke, Current Treatment Options in Cardiovascular Medicine. 2004, 6: 199-207.

Cheung R.T.F., Editorial Advisory Board Member, MIMS Neurology & Psychiatry Guide. 2004.

Cheung R.T.F., Hong Kong Stroke Symposium & Workshop Program Book. 2003.

Cheung R.T.F., Honorary Secretary, Hong Kong Stroke Society. 2004.

Cheung R.T.F., Medical Editorial Board Member, Doctor. 2004.

Cheung R.T.F., Professional Advisor, The Hong Kong Neuro-Muscular Disease Association. 2004.

Cheung R.T.F., Professional Advisor, The Hong Kong Society for Rehabilitation. 2004.

Cheung R.T.F., Eliasziw M., Meldrum H.E., Fox A.J. and Barnett H.J., Risk, types, and severity of intracranial hemorrhage in patients with symptomatic carotid artery stenosis, Stroke. 2003, 34: 1847-1851.

Cheung R.T.F. and Fung P.C.W., Role of free radicals in developing drugs for stroke, Drug Medi-Bank: Hong Kong. 2004, 1: 4-7.

Cheung R.T.F., Stroke prevention in clinical practice for primary care physicians, Hong Kong Practitioner. 2004, 26: 81-92.

Cheung R.T.F. and Zou L., Use of the original, modified, or new intracerebral hemorrhage score to predict mortality and morbidity after intracerebral hemorrhage, Stroke. 2003, 2003: 1717-1722.

Cheung R.T.F., Vice-Chairman, The Hong Kong Brain Foundation. 2004.

Cheung R.T.F., Vice-President, The Hong Kong Neurological Society. 2004.

Lee R., Cheung R.T.F., Hung K.N., Au Yeung K.M., Leong Fung L.L.Y., Chan F.L. and Lee T.Y., Use of CT perfusion to differentiate between brain tumor and cerebral infarction, Cerebrovascular Diseases. 2004, 18: 77-83.

Li G., Cheung R.T.F., Au Yeung K.M. and Yang E.S., A fMRI study of language-implicated acupoint in stroke patients with expressive aphasia, Society for Neuroscience 2003 Annual Meeting. 2003.

Li G., Cheung R.T.F., Au Yeung K.M. and Yang E.S., A fMRI study on activation of principal and non-principal sites during acupuncture of the hands in stroke patients with expressive aphasia, The 11th Chinese Congress of Radiology. 2003.

Li G., Cheung R.T.F., Au Yeung K.M. and Yang E.S., A functional magnetic resonance imaging study of sensory-deficit-related acupoints in stroke patients with persistent sensory deficits, Neurology. 2004, 62(Suppl 5): A536.

Li G., Cheung R.T.F., Lee T.M.C. and Yang E.S., An fMRI Study of Neural Activations in the Aged and Illiterates, ISMRM, 12th Scientific Meeting & Exhibition. Kyoto, Japan, 2004, 1156.

Li G., Huang L., Cheung R.T.F., Liu S.R., Ma Q. and Yang E.S., Cortical activations upon stimulation of the sensorimotor-implicated acupoints, Magnetic Resonance Imaging. 2004, 22: 639-644.

Mak W., Cheng T.S., Fong C.Y.G., Tsang K.L., Chan K.H., Cheung R.T.F. and Ho S.L., Re-exploring the cerebrospinal fluid (CSF) to serum glucose ratio, 9th Medical Research Conference. 2004.

Ng P.W., Huang C.Y., Cheung R.T.F., Wong K.S., Wong C.K. and Lam J.M., Consensus statements on ischaemic stroke care, Hong Kong Medical Journal. 2004, 10: 124-129.

Ooi C.G.C., Tsang K.W.T., Cheung R.T.F., Khong P.L., Ho I.W.T., Ip M.S.M., Tan C.M., Ngan H., Lam W.K., Chan F.L. and Chan M.M.W., Silicosis in 76 men: qualitative and quantitative CT evaluation - clinical-radiologic correlative study., Radiology . 2003, 228(3): 816-25.

Yu Y.L., Fong K.Y., Ho S.L. and Cheung R.T.F., [Total of 18 chapters- contribution about 1/4: preface, four chapters and 2 half-chapters], Neurology in Practice. Hong Kong, Hong Kong University Press, 2003, 3rd edition.

Zou L., Tang F. and Cheung R.T.F., Mice overexpressing amyloid precursor protein (APP) and harbouring presenilin-1 (PS1) gene are more susceptible to photothrombotic stroke and post-stroke memory impairment than APP transgenic mice, Society for Neuroscience Annual Meeting. 2003.

Zou L., Tang F. and Cheung R.T.F., Presenilin-1 (PS1) increased susceptibility to photothrombotic stroke and post-stroke memory impairment in transgenic mice overexpressing amyloid precursor protein (APP), 9th Medical Research Conference. 2004.

Researcher : Cheung WC

List of Research Outputs

Au W.Y., Cheung W.C., Lam C.C.K. and Kwong Y.L., Two factor XI gene mutations in a Chinese family with factor XI deficiency, American Journal of Hematology. 2003, 74: 136-8.

Au W.Y., Lam C.C.K., Lam C.C.K., Lam C.C.K., Cheung W.C. and Kwong Y.L., Two novel factor X deficiency mutations in a Chinese family, Annals of Hematology. 2004, 83: 304-306.

Chim J.C.S., Fung T.K., Cheung W.C., Liang R.H.S. and Kwong Y.L., SOCS1 and SHP1 Hypermethylation in Multiple Myeloma: Implications for Epigenetic Activation of the Jak/STAT pathway, Blood. 2004, 103: 4630-4635.

Researcher : Cheung WMW

List of Research Outputs

Chu W.K., Cheung W.M.W. and Kwong Y.L., Differential effects of 9-cis, 13-cis and all-trans retinoic acids on the neuronal differentiation of human neuroblastoma cells, Neuroreport. 2003, 14(15): 1935-1939.

Researcher : Chim JCS

List of Research Outputs

Au W.Y., Fung A., Chim J.C.S., Lie A.K.W., Liang R.H.S., Ma E.S.K., Chan C.H., Wong K.F. and Kwong Y.L., FLT-3 aberrations in acute promyelocytic leukaemia: clinicopathological associations and prognostic impact, British Journal of Haematology. 2004, 125(4): 463-469.

Au W.Y., Pang A.W.K., Choy C.K.W., Chim J.C.S. and Kwong Y.L., Quantification of circulating Epstein-Barr virus (EBV) DNA in the diagnosis and monitoring of natural killer cell and EBV-positive lymphomas in immunocompetent patients, Blood. 2004, 104(1): 243-9.

Chan S., Huang F., Chim J.C.S., Ma E.S.K., Law H.K.W., Lau Y.L. and Chan G.C.F., Dendritic cells (DBS) can be induced from marrows of both newly diagnosed lymphoid and myeloid leukaemia but they demonstrated different morphological and immunological behaviours, Joint Annual Scientific Meeting 2003 of the Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association Limited, QEH, Hong Kong, 13 December 2003. 119.

Chim J.C.S., Wong A.S.Y. and Liang R.H.S., Aberrant gene promoter methylation in acute promyelocytic leukaemia: profile and prognostic significance, British Journal of Haematology. 2003, 122(4): 571-578.

Chim J.C.S., Wong A.S.Y. and Kwong Y.L., Aberrant methylation in acute promyelocytic leukemia: profile and prognostic significance, British Journal of Haematology. 2003, 122: 571-578.

Chim J.C.S., Wong A.S.Y. and Kwong Y.L., Absence of p300 gene promoter methylation in acute leukemia, Cancer Genetics and Cytogenetics. 2004, 150: 164-7.

Chim J.C.S. and Ooi C.G.C., Bull neck in Hodgkin’s disease, Haematologica. 2004, 89(5): EIM11.

Chim J.C.S., Li F.K. and Chan K.W., Cast nephropathy in multiple myeloma, Haematologica. 2004, 89(4): EIM08.

Chim J.C.S., Fung T.K. and Liang R.H.S., Disruption of INK4/CDK/Rb Cell cycle pathway by gene hypermethylation in multiple myeloma and MGUS., Leukemia. 2003, 76: 169-176.

Chim J.C.S., Cheung N.T., Wong K.C. and Hong F., Electronic clinical practice guidelines: current status and future prospects in Hong Kong, Hong Kong Medical Journal. 2003, 9: 299-301.

Chim J.C.S., Wong A.S.Y. and Kwong Y.L., Epigenetic dysregulation of the Jak/STAT pathway by frequent aberrant methylation of SHP1 but not SOCS1 in acute leukaemias, Annals of Hematology. 2004, 83(8): 527-32.

Chim J.C.S., Wong A.S.Y. and Kwong Y.L., Epigenetic inactivation of INK4/CDK/RB cell cycle pathway in acute leukemias, Annals of Hematology . 2003, 82(12): 738-42.

Chim J.C.S., Hu W.H., Loong F., Ooi C.G.C. and Liang R.H.S., Gastrointestinal manifestations of mantle cell lymphoma, Gastrointestinal Endoscopy. 2003, 59: 931-933.

Chim J.C.S., Loong F. and Chu K.M., MALT lymphoma of small bowel: an elusive cause of recurrent upper GIB, Leuk lymphoma. 2004, 45(2): 405-7.

Chim J.C.S., Ma E.S.K. and Ooi C.G.C., Magnetic Resonance (MR) Imaging of Leptomeningeal Lymphoma, British Journal of Haematology. 2004, 124(5): 566.

Chim J.C.S., Loong F., Ooi C.G.C. and Liang R.H.S., Mantle cell lymphoma of prostate gland, Journal of Clinical Oncology. 2003, 21: 4456-4458.

Chim J.C.S., Kwong Y.L., Fung T.K. and Liang R.H.S., Methylation profiling in multiple myeloma, Leukemia Research. 2004, 28: 379-385.

Chim J.C.S., Shek T.W.H., Chung L.P. and Liang R.H.S., Multiple lymphomatous polyposis in lymphoma of colon, Journal of Clinical Oncology. 2003, 953 – 955.

Chim J.C.S., Ma A.Y., Au W.Y., Choy C.K.W., Lie A.K.W., Liang R.H.S., Yau C.C. and Kwong Y.L., Primary nasal natural killer cell lymphoma : long term treatment outcome and relationship with the international prognostic index., Blood. 2004, 103: 216-221.

Chim J.C.S., Fung T.K., Cheung W.C., Liang R.H.S. and Kwong Y.L., SOCS1 and SHP1 Hypermethylation in Multiple Myeloma: Implications for Epigenetic Activation of the Jak/STAT pathway, Blood. 2004, 103: 4630-4635.

Chim J.C.S., Wong K.Y., Loong F. and Srivastava G., SOCS1 and SHP1 hypermethylation in mantle cell lymphoma and follicular lymphoma: implications for epigenetic activation of the Jak/STAT pathway, Leukemia. 2004, 18(2): 356-372.

Chim J.C.S., Ooi C.G.C., Loong F. and Liang R.H.S., Solitary bone plasmacytoma : Role of MRI and PET, Journal of Clinical Oncology. 2004, 22: 1328-1330.

Ma S.Y., Au W.Y., Chim J.C.S., Lie A.K.W., Lam C.C.K., Tse E.W.C., Leung A.Y.H., Liang R.H.S. and Kwong Y.L., Fludarabine, mitoxantrone and dexamethasone in the treatment of indolent B-and T-cell lymphoid malignancies Chinese patients, British Journal of Haematology. 2004, 124: 754-761.

Ma S.Y., Lie A.K.W., Au W.Y., Chim J.C.S., Kwong Y.L. and Liang R.H.S., Non-myeloablative allogeneic peripheral stem cell transplantation for multiple myeloma, Hong Kong Medical Journal. 2004, 10: 77-83.

Researcher : Ching CK

List of Research Outputs

Wong B.C.Y., Lam S.K., Wong R.W.M., Chen J.S., Zheng T., Feng R., Lai K.C., Hu H.C., Yuen S.T., Leung S.Y., Fong D.Y.T., Ho J.C.Y., Ching C.K. and Chen J.S., Helicobacter pylori Eradication to Prevent Gastric Cancer in a High-Risk Region of China: a Randomized Controlled Trial, The Journal of American Medical Association. 2004, 291(2): 187-194.

Wong B.C.Y., Lam S.K., Wong R.W.M., Chen J.S., Zheng T., Feng R., Lai K.C., Hu H.C., Yuen S.T., Leung S.Y., Fong D.Y.T., Ho J.W.C. and Ching C.K., Helicobacter pylori eradication to prevent gastric cancer in a high-risk region in China: A randomized controlled trial, JAMA. 2004, 291(2): 187-194.

Researcher : Chiu EKW

Project Title:	Bone marrow transplantation in Hong Kong
Investigator(s):	Dr. Chiu E.K.W., Prof. Chan T.K., Prof. Liang R.H.S., Prof. Todd D.
Department:	Medicine
Source(s) of Funding:	Blood Cancer Research Fund
Start Date:	05/1990

Abstract:

To study prospectively the clinical results of bone marrow transplantation in Hong Kong Chinese patients with haematological malignancies.

Project Title:	Bone marrow transplantation in Hong Kong
Investigator(s):	Dr. Chiu E.K.W., Prof. Chan T.K., Prof. Liang R.H.S., Prof. Todd D.
Department:	Medicine
Source(s) of Funding:	Pfizer Asia Corporation
Start Date:	05/1990

Abstract:

To study prospectively the clinical results of bone marrow transplantation in Hong Kong Chinese patients with haematological malignancies.

Project Title:	G-CSF trial
Investigator(s):	Dr. Chiu E.K.W.
Department:	Medicine
Source(s) of Funding:	Roche Pharmaceuticals and Chemicals Ltd.
Start Date:	01/1992

Abstract:

To study G-CSF trial.

Researcher : Chow WS

List of Research Outputs

Au W.Y., Tsang J., Cheng T.S..., Chow W.S., Woo Y.C., Ma E.S.K. and Tam S.C.F., Cough mixture abuse as a novel cause of megaloblastic anemia and peripheral neuropathy, British Journal of Haematology. 2003, 123: 956-958.

Chow W.S., So T., Tan K.C.B., Choy A., Hung V., Hui C.K., Chu D., Chan C.K. and Lam K.S.L., An evaluation of the effectiveness of a step-down clinic for diabetes in Hong Kong, 18th Congress of International Diabetes Federation, 24-29 Aug 2003, Paris, France. 2003, A103(286).

Chow W.S., Tse H.F., Tan K.C.B., Lo K.W., Lee K.F. and Lam K.S.L., Effect of intensifying glycemic control on vasomotor functions in subjects with type 1 diabetes mellitus, American Diabetes Association 64th Scientific Sessions, Orlando , June 2004.

Chow W.S., Tan K.C.B., Xu A., Ai V.H.G., Tam S.C.F. and Lam K.S.L., Hypoadiponectinemia is associated with endothelial dysfunction, 5th Annual Scientific Meeting of Hong Kong Society of Endocrinology, Metabolism and Reproduction, October 2003, Hong Kong. 2003.

Chow W.S., Tan K.C.B., Xu A., Lam C.W., Ai V.H.G., Tam S.C.F. and Lam K.S.L., Hypoadiponectinemia is associated with impaired endothelial vasomotor function, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Lam K.S.L., Wat N.M.S., Chow W.S., Tso A.W.K., Thomas G.N. and Lam T.H., The Metabolic Syndrome: clinical implications and managements, Journal of the HK College of Cardiology . 2003, 11(Suppl 2): B39-42.

Leung G.K.K., Chow W.S., Tan K.C.B., Fan Y.W. and Lam K.S.L., Metastatic melanoma of the pituitary gland, Journal of Neurosurgery. 2003, 99(5): 913-915.

Tan K.C.B., Chow W.S., Tam S.C.F., Bucala R. and Betteridge D.J., Association between acute phase reactants and advanced glycation end products in type 2 diabetes mellitus, Diabetes Care. 2004, 27: 223-228.

Tan K.C.B., Xu A., Chow W.S., Ai V.H.G., Tam S.C.F. and Lam K.S.L., Association between adiponectin and endothelial dysfunction, XIIIth International Symposium on Atherosclerosis, Sep 28-oct 2, 2003, Kyoto, Japan. European Atherosclerosis Society, 2003, 1P-0167.

Tan K.C.B., Tso A.W.K., Chow W.S., Ma O.C.K., Pang W.C., Tam S.C.F. and Lam K.S.L., Determinants of postprandial triglyceride and remnant-like lipoproteins in type 2 diabetes, he 4th Congress of Asian Pacific Society of Atherosclerosis and Vascular Diseases. Bali, May 2004 . 2004.

Tan K.C.B., Chow W.S., Wong Y., Shiu S.W.M. and Tam S.C.F., Effect of losartan on plasma C-reative protein in type 2 diabetic patients with microalbuminuria., In: Tan KCB, Chow WS, Wong Y, Shiu SWM, Tam SCF., Diabetes Care. 2003, 25: 1254.

Tan K.C.B., Xu A., Chow W.S., Lam C.W., Ai V.H.G. and Tam S.C.F., Hypoadiponectinemia is associated with impaired endothelial vasomotor function, Journal of Clinical Endocrinology and Metabablism. 2004, 89: 765-769.

Tan K.C.B., Xu A., Chow W.S., Ai V.H.G., Tam S.C.F. and Lam K.S.L., Hypoadiponectinemia is associated with impaired endothelium-dependent vasodilatation, Journal of Endocrinology and Metabolism. 2004, 89: 765-9.

Researcher : Choy CBY

List of Research Outputs

Choy C.B.Y., Chan D.T.M., Lo R.S.K., Lo W.K. and Lai K.N., Renal transplantation in patients with primary immunoglobulin A nephropathy, Nephrology Dialysis Transplantation. 2003, 18: 2399-2404.

Li F.K., Tse K.C., Lam M.F., Yip T.P.S., Lui S.L., Chan G.S.W., Chan K.W., Chan E.Y.T., Choy C.B.Y., Lo W.K., Chan D.T.M. and Lai K.N., Incidence and outcome of antiglomerular basement membrane disease in Chinese, Nephrology (Carlton). 2004, 9: 100-104.

Lui S.F., Li F.K., Choy C.B.Y., Chan D.T.M., Lo W.K. and Lai K.N., Long-term Outcome of Isoniazid Prophylaxis Against Tuberculosis in Chinese Renal Transplant Recipients. , Transplant Infectious Disease. 2004, 6: 55-56.

Tse K.C., Lam M.F., Yip P.S., Li F.K., Choy C.B.Y., Lai K.N. and Chan D.T.M., Idiopathic Minimal Change Nephrotic Syndrome In Older Adults: Steroid Responsiveness And Pattern Of Relapses, Nephrology, Dialysis and Transplantation. 2003, 18: 1316-1320.

Tse K.C., Yip P.S., Lam M.F., Choy C.B.Y., Li F.K., Lui S.L., Lo W.K., Chan D.T.M. and Lai K.N., Star Fruit Intoxication In Uraemic Patients: Case Series And Review Of The Literature, Internal Medicine Journal. 2003, 33: 314-316.

Researcher : Chu LW

Project Title:	A dementia outreach programme in Central, Western and Southern districts of Hong Kong
Investigator(s):	Dr. Chu L.W., Prof. Lam K.S.L., Prof. Lee P.W.H.
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation Grant
Start Date:	09/2003

Abstract:

To achieve early detection of dementia, through an outreach dementia-screening programme.

Researcher : Chu WK

List of Research Outputs

Chu W.K., Cheung W.M.W. and Kwong Y.L., Differential effects of 9-cis, 13-cis and all-trans retinoic acids on the neuronal differentiation of human neuroblastoma cells, Neuroreport. 2003, 14(15): 1935-1939.

Researcher : Chung BCY

List of Research Outputs

Tse K.C., Chan D.T.M., Wong S.S.Y., Chan K.W., Lam M.F., Chan K.H.N., Li F.K., Chung B.C.Y. and Lai K.N., Granulomatous interstitial nephritis of the allograft kidney associated with rhodococcal pulmonary infection. Nephrol Dial Transplant, Nephrology Dialysis Transplantation. 2004, 19: 486-490.

Researcher : Cui J

List of Research Outputs

Li G., Xia H.H.X., Chen M.H., Peng J., Gu Q., Cui J., Cho C.H., Lam S.K., Lin M.C., Berg D.E., Feng Z., Langenbach R., Kung H. and Wong B.C.Y., Cyclooxygenase-2 Gene Disruption Enhances Gastric Inflammation but Inhibits Gastric Epithelial Proliferation Induced by H. pylori Infection, Gastroenterology. 2004, 126 (4 Suppl 2): W907.

Tu S., Jiang X., Lin M.C., Cui J., Yang Y., Lum C.T., Zou B., Zhu Y.B., Jiang S.H., Wong W.M., Chan O.O., Yuen M.F., Lam S.K., Kung H. and Wong B.C.Y., Suppression of Survivin Expression Inhibits in vivo Tumorigenicity and Angiogenesis in Gastric Cancer, Cancer Research. 2003, 63(22): 7724-7732.

Wong B.C.Y., Jiang X., Lin M.C., Tu S., Cui J., Jiang S.H., Wong R.W.M., Yuen M.F., Lam S.K. and Kung H., Cyclooxygenase-2 Inhibitor (SC-236) Suppresses Activator Protein-1 through c-Jun NH2-Terminal Kinase, Gastroenterology. 2004, 126: 136-147.

Researcher : Dan Q

List of Research Outputs

Dan Q., Xu A., Cheng K.Y., Xu J. and Lam K.S.L., Adiponectin suppresses the proliferation of human aortic smooth muscle cells induced by advanced glycation and end products, The 3rd International Huaxia Congress of Endocrinology, May 25 – 28, 2004, Shanghai, China. 2004.

Dan Q., Yin S., Chung S.K., Chung S.S.M. and Lam K.S.L., Interaction between the polyol pathway and non-enzymatic glycation on aortic smooth muscle cell migration and monocyte adhesion in a transgenic mouse model, 13th International Symposium on Atherosclerosis, September 28 – October 2, 2003, Kyoto, Japan. 2003.

Dan Q., Yin S., Wong L.C., Chung S.K., Chung S.S.M. and Lam K.S.L., Interaction between the polyol pathway and non-enzymatic glycation on aortic smooth muscle cell migration and monocyte adhesion in a transgenic mouse model, 15th Annual Scientific Meeting of Hong Kong Society of Endocrinology, Metabolism and Reproduction, October 2003, Hong Kon. 2003.

Dan Q., Yin S., Wong L.C., Chung S.K., Chung S.S.M. and Lam K.S.L., Interaction between the polyol pathway and non-enzymatic glycation on aortic smooth muscle cell migration and monocyte adhesion in a transgenic mouse model, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Dan Q., Yin S., Wong L.C., Chung S.K., Chung S.S.M. and Lam K.S.L., Interaction between the polyol pathway and non-enzymatic glycation on aortic smooth muscle cell mirgration and moncyte adhesion in a transgenic mouse model, XIIIth International Symposium on Atherosclerosis, Sep 28-Oct 2, 2003, Kyoto, Japan. European Atherosclerosis Society, 2003, 1P-0137.

Dan Q., Wong L.C., Cheng K.Y., Chung S.S.M., Chung S.K. and Lam K.S.L., The polyol pathway and diabetic atherosclerosis, The 3rd International Huaxia Congress of Endocrinology, May 25 – 28, 2004, Shanghai, China. 2004.

Lam K.S.L., Dan Q., Yin S., Wong L.C., Chung S.K. and Chung S.S.M., Interaction between non-enzymatic glycation and the polyol pathway on mesangial cell gene expression in an aldose reductase transgenic mouse model, The 18th International Diabetes Federation Congress, August 24-29, 2003, Paris, France. 2003.

Xu J., Dan Q., Chan V.N.Y., Wat N.M.S., Tam S.C.F., Tiu S.C., Lee K.F., Siu S.C., Tsang M.W., Fung L.M., Chan K.W. and Lam K.S.L., Genetic and clinical characteristics of maturity-onset diabetes of the young in Chinese patient, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Researcher : Du X

List of Research Outputs

Du X., Gao Z., Lau C.P., Chiu S.W., Tse H.F., Baumgarten C.M. and Li G.R., Differential effects of tyrosine kinase inhibitors on volume-sensitive chloride current in human atrial myocytes: evidence for dual regulation by Src and EGFR kinases, Journal of General Physiology. 2004, 123: 427-39.

Researcher : Epstein R

Project Title:	Evolutionarily conserved patterns of synonymous codon bias in wild-type orthologous and paralogous gene sequences, and comparison with patterns of bias in human tumour genomes
Investigator(s):	Prof. Epstein R.J.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	09/2003

Abstract:

To clarify whether these evident associations of synonymous codon bias with function and/or with methylation are interdependent or independent.

List of Research Outputs

Cheung Y.B., Khoo K.S., Wong Z.W., See H.T., Toh H.C., Epstein R., Ng G.Y. and Tan S.B., Quick-FLIC: a short questionnaire for assessing quality of life of cancer patients., Acta Oncologica. 2003, 42(1): 36-42.

Epstein R., Human Molecular Biology. Cambridge, Cambridge University Press, 2003, 623 pp.

Epstein R., Learning from the problems of problem-based learning., BMC Medical Education. 2004, 4: 1.

Epstein R., Medicine for Examination. 4th ed.. Edinburgh, Churchill Livingstone, Elsevier, 2003, 432 pp.

Epstein R., Pathogenesis of cancer., In: Ong YY, Tan P et al (eds), A clinical Approach to Medicine. 2nd Ed.. World Scientific, 2004.

Lim Y.P., Diong L.S., Qi R., Druker B.J. and Epstein R., Phosphoproteomic fingerprinting of growth factor signaling and anticancer drug action in human tumor cells., Molecular Cancer Therapeutics. 2003, 2(12): 1369-77.

Lim Y.P., Wong C.Y., Ooi L.L., Druker B.J. and Epstein R., Selective tyrosine hyperphosphorylation of cytoskeletal and stress proteins in primary human breast cancers: Implications for adjuvant use of kinase-inhibitory drugs, Clinical Cancer Research. 2004, 10: 3980-7.

Lin K., Tan S.B., Kolatkar P.R. and Epstein R., Nonrandom intragenic variations in patterns of codon bias implicate a sequential interplay between transitional genetic drift and funcitonal amino acid selection., Journal of Molecular Evolution. 2003, 57: 538-545.

Yau T. and Epstein R., Radiotherapy and tamoxifen in women with completely excised ductal carcinoma in situ., Lancet. 2003, 362(9390): 1154-5.

Researcher : Feng R

List of Research Outputs

Wong B.C.Y., Lam S.K., Wong R.W.M., Chen J.S., Zheng T., Feng R., Lai K.C., Hu H.C., Yuen S.T., Leung S.Y., Fong D.Y.T., Ho J.C.Y., Ching C.K. and Chen J.S., Helicobacter pylori Eradication to Prevent Gastric Cancer in a High-Risk Region of China: a Randomized Controlled Trial, The Journal of American Medical Association. 2004, 291(2): 187-194.

Wong B.C.Y., Lam S.K., Wong R.W.M., Chen J.S., Zheng T., Feng R., Lai K.C., Hu H.C., Yuen S.T., Leung S.Y., Fong D.Y.T., Ho J.W.C. and Ching C.K., Helicobacter pylori eradication to prevent gastric cancer in a high-risk region in China: A randomized controlled trial, JAMA. 2004, 291(2): 187-194.

Researcher : Feng Z

List of Research Outputs

Li G., Xia H.H.X., Chen M.H., Peng J., Gu Q., Cui J., Cho C.H., Lam S.K., Lin M.C., Berg D.E., Feng Z., Langenbach R., Kung H. and Wong B.C.Y., Cyclooxygenase-2 Gene Disruption Enhances Gastric Inflammation but Inhibits Gastric Epithelial Proliferation Induced by H. pylori Infection, Gastroenterology. 2004, 126 (4 Suppl 2): W907.

Researcher : Fong CY

List of Research Outputs

Chan O.O., Yuen M.F., Lam C.M., Fong C.Y., Wong B.C.Y. and Lai C.L., Prevalence and Characteristics of Familial Hepatocellular Carcinoma Caused by Chronic Hepatitis B Infection in Hong Kong, Alimentary Pharmacology and Therapeutics. 2004, 19(4): 401-6.

Kung A.W.C., Lau K.S., Fong C.Y. and Chan V.N.Y., Association of novel single-nucleotide polymorphisms in the dihydropyridine sensitive L-type a-3 calcium channel (CACNL1a3) and thyrotoxic periodic paralysis (TPP) , American thyroid Association 75th Annual Meeting, 16-21 September 2003, Palm Beach, USA. Thyroid. 2003, 13(7): 672.

Researcher : Fong CYG

List of Research Outputs

Chan K.H., Mak W., Tsang K.L., Fong C.Y.G., Cheng T.S., Cheung R.T.F. and Ho S.L., Idiopathic relapsing transverse myelitis: experience of a regional hospital, 9th Medical Research Conference. 2004.

Chan K.H., Cheung R.T.F., Mak W., Fong C.Y.G., Tsang K.L., Cheng T.S. and Ho S.L., Predictive factors for ischemic strokes complicating tuberculous meningitis, Hong Kong Medical Journal. 2004, 10(Suppl 1): 34.

Cheng T.S., Mak W., Fong C.Y.G., Chan K.H., Ho S.L. and Cheung R.T.F., Clinical relevance of severe initial hypertension in acute intracerebral haemorrhage, Hong Kong Medical Journal. 2004, 10(Suppl 1): 34.

Mak W., Cheng T.S., Fong C.Y.G., Tsang K.L., Chan K.H., Cheung R.T.F. and Ho S.L., Re-exploring the cerebrospinal fluid (CSF) to serum glucose ratio, 9th Medical Research Conference. 2004.

Researcher : Fong HY

List of Research Outputs

Tao A.W.K., Wat N.M.S., Xu A., Rong R., Cheng K.Y., Fong H.Y., Janus E.D. and Lam K.S.L., The adiponectin gene T45G polymorphism is associated with central obesity and glucose intolerance in southern Chinese, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Researcher : Fong KY

List of Research Outputs

Yu Y.L., Fong K.Y., Ho S.L. and Cheung R.T.F., [Total of 18 chapters- contribution about 1/4: preface, four chapters and 2 half-chapters], Neurology in Practice. Hong Kong, Hong Kong University Press, 2003, 3rd edition.

Researcher : Fung FMY

List of Research Outputs

Wong W.M., Gu Q., Wang W., Fung F.M.Y., Berg D.E., Lai K.C., Xia H.H.X., Hu H.C., Chan C.K., Chan O.O., Yuen M.F., Hui C.K., Lam S.K. and Wong B.C.Y., Effects of Primary Metronidazole and Clarithromycin Resistance to Helicobacter pylori on Omeprazole, Metronidazole, and Clarithromycin Triple-Therapy Regimen in a Region with High Rates of Metronidazole Resistance, Clinical Infectious Diseases. 2003, 37(7): 882-9.

Researcher : Fung PCW

Project Title:	Detection of superoxide on organs of animal models
Investigator(s):	Prof. Fung P.C.W.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2001
Completion Date:	10/2003

Abstract:

To use the Relative New Spin trap EMPO, detect the concentrations of superoxide (and hydroxyl) free radical in organs suffered from ischemia injury using Electron Paramagnetic Resonance Spectronscopy (EPR).

Project Title:	Development of a novel natural antioxidant with strong anti-aging and protective properties for skin
Investigator(s):	Prof. Fung P.C.W., Dr. Shen J.G.
Department:	Medicine
Source(s) of Funding:	RGC Projects (Block Grant Funded)
Start Date:	07/2002

Abstract:

To develop a novel antioxidants from herbal products which can scavenge superoxide, hydroxyl and lipid peroxide free radicals in skin.

Project Title:	Roles of plasma membrane cholesterol homeostasis in regulating neuronal oxidative damage of ischemic stroke
Investigator(s):	Prof. Fung P.C.W., Dr. Shen J.G.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2003

Abstract:

To understand the roles of plasma membrane cholesterol homeostasis in protecting neuronal cells from oxidative damage during ischemic stroke.

List of Research Outputs

Chan P.S., Shen J., Fung P.C.W. and Cheung R.T.F., Overproduction of nitric oxide from neuronal nitric oxide synthase during ischemia is partly mediated via activation of neuropeptide Y Y1 receptors, Neurology. 2004, 62(Suppl 5): A144.

Chan P.S., Shen J., Fung P.C.W. and Cheung R.T.F., Overproduction of nitric oxide from neuronal nitric oxide synthase during ischemia is partly mediated via activation of neuropeptide Y-Y1 receptors, 9th Medical Research Conference. 2004.

Cheung B.M.Y., Law C.Y., Fung P.C.W., Tsang K.W.T., Tan K.C.B., Kumana C.R. and Lau C.P., Randomised Trial of Candesartan and Enalapril (RACE) in the treatment of hypertension (P-215), In: FC Tuluney, M Orme, Sixth Congress of European Association of Clinical Pharmacology adn Therapeutics - European Collaboration: Towards Drug Development and Rational Drug Therapy . 2003, 128.

Cheung B.M.Y., Law C.Y., Fung P.C.W., Tsang K.W.T., Tan K.C.B., Kumana C.R. and Lau C.P., Randomised trial of candesartan and enalapril (RACE) in the treatment of hypertension-final results, Hong Kong Medical Journal. 2003, 9(1) Suppl: 24.

Cheung R.T.F. and Fung P.C.W., Role of free radicals in developing drugs for stroke, Drug Medi-Bank: Hong Kong. 2004, 1: 4-7.

Fung P.C.W., Shen J., Xin W.J. and Zhao B.L., Ginkgo bilobia extract (EGB 761) against hypoxia-reoxygenated induced cardiomyocyte apoptosis via inhibiting NO/ONOO-pathway and adjusting bcl-2,p53 and p21/wafl/cipl expressions., Free Radical Bio Med. 2003, 33 Suppl.1: 213.

Ho K.M.T., Shen J., Fung P.C.W., Lee F.C.W. and Tam P.C., Effect of ischemia-reperfusion on nitric oxide production in the pig-bladder (Abstract), European Urology. 2003, No. 1, Supplements 2: 170.

Khan N., Shen J., Chang T...Y..., Chang C...Y..., Fung P.C.W., Grinberg O., Demidenko E. and Swartz H., Plasma membrance cholesterol: A possible barrier to intracellular oxygen in CHO cells and their mutants,, Biochemistry. 2003, 42: 23-29.

Li H., Yu T.F. and Fung P.C.W., The positive magnetic susceptibility for Rb₃C₆₀ superconductor and the differential paramagnetic effect, Journal of Superconductivity. Plenum Pub. Corp., 2004, 17: 369-372.

Peng Y., Yang P., Guo Y., Ng S.M., Liu J., Fung P.C.W., Tay D.K.C., Ge J., He M.L., Kung H. and Lin M.C., Catalase and peroxiredoxin 5 protect xenopus embryos against alcohol-induced ocular anomalies, Investigative Ophthalmology & Visual Science. 2004, 45 No. 1: 23-29.

Ren J., Chang C., Fung P.C.W., Shen J. and Chan F.H.Y., Free Radical EPR Spectroscopy Analysis using blind source separation, Journal of Magnetic Resonance . 2004, 166(1): 82-91.

Ren J., Shen J., Chang C., Fung P.C.W. and Chan F.H.Y., Identification of Superoxide and Hydroxy1 Radicals EPR Spectra From Complex Spectra Using Blind Source Separation Method, World Congress on Medical Physics and Biomedical Engineering. Sydney, Australia, IFBME, 2003, 4 pages.

Shen J., Lee W.S. and Fung P.C.W., Cellular cholesterol ester accumulation promotes productions of reactive oxygen species and nitric oxide and apoptotic cell death in Chinese hamster ovary (CHO) cells under oxidative stress, 9th Hong Kong Medical Research Conference. 2004, 12.

Shen J., Tong L., Liao C.L. and Fung P.C.W., Evaluation of Buyang-Huanwu Decoction (BYHWD), a traditional Chinese Medicinal Formula, against ischemic brain injury in vivo and in vitro., 9th Hong Kong Medical Research Conference . 2004, 13.

Shen J., Fung P.C.W. and Chang T.Y., Plasma membrane cholesterol homeostasis is essential for preventing oxidative damage in Chinese hamster ovary cells. , Hong Kong Medical Journal. 2003, 9(suppl.): 40.

Shen J., Lee W.S. and Fung P.C.W., Reactive oxygen species mediate intracellular cholesterol accumulation via modulating caveolin-1 expression in Chinese hamster ovary cells. , Stress, Signalling and Control. 679th Biochemical Society Meeting at University of Essex, UK, . 2003, 63.

Shen J., Lu G., Fung P.C.W. and Chu K...W..., Ultrastructural changes of mitochondria in colorectal adenocarcinoma patients, 9th Hong Kong Medical Research Conference 1. 2004.

Ting K.H., Shen M.F., Fung P.C.W. and Chan F.H.Y., Multi-channel Fourier Packet Transform of EEG: Optimal Representation and Time-Varying Coherence, IEEE-EMBS-APBME 2003 Asian-Pacific Conference on Biomedical Engineering. Kyoto-Osaka-Nara, Japan, IEEE, 2003, 120-121.

Ting K.H., Shen M., Fung P.C.W. and Chan F.H.Y., Multi-channel fourier packet transform of EEG: optimal representation and time-varying coherence, Proceedings of IEEE-EMBS-APBME 2003 Asian-Pacific Conference on Biomedical Engineering, Kyoto-Osaka-Nara, Japan. 2003.

Ting K.H., Chang C., Leung A., Chan C.C.H., Fung P.C.W. and Chan F.H.Y., Second Order Statistics Based Blind Source Separation for Artiface Correction of Short ERP Epochs, IEEE-EMBS-APBME 2003 Asian-Pacific Conference on Biomedical Engineering. Kyoto-Osaka-Nara, Japan, IEEE, 2003, 186-187.

Ting K.H., Chang C., Leung A.W.S., Chan C.C.H., Fung P.C.W. and Chan F.H.Y., Second order statistics based blind source separation for artifact correction of short ERP epochs, Proceedings of IEEE-EMBS-APBME 2003 Asian-Pacific Conference on Biomedical Enginerring, Kyoto-Osaka-Nara, Japan. 2003.

Ting K.H., Qiu W., Shen M.F., Fung P.C.W. and Chan F.H.Y., Tracking P300 in Single-Trial Oddball ERP with Adaptive Filtering and Radial-Basis-Function Network, World Congress on Medical Physics and Biomedical Engineering. Sydney, Australia, IFBME, 2003, 4 pages.

Ting K.H., Qiu W., Shen M., Fung P.C.W. and Chan F.H.Y., Tracking P300 in single-trial oddball ERP with adaptive filtering and radial-basis-function network, Proceedings of WC2003 World Congress on Medical Physics and Biomedical Engineering, Sydney, Australia. 2003.

Xu R., Li X. and Fung P.C.W., U.S. patent, "Composition and methods preventing and treating liver cirrhosis", 2003.

Xu W...C..., Tse H.F., Chan F.H.Y., Fung P.C.W. and Lau C.P., U.S. Patent, "A bayesian discriminator for rapidly detecting arrhythmias", 2003.

Zheng Z., Li D., Fung P.C.W., Pei Z., Ramsden D...B... and Ho S.L., COX-2-deficient mice are less prone to MPRP-neurotoxicity than wild-type mice, , Molecular Neuroscience. 2003, 14: 1927-1929.

Researcher : Fung TK

List of Research Outputs

Au W.Y., Fung T.K., Ma E.S.K., Liang R.H.S. and Kwong Y.L., Low frequency of FLT3 gene internal tandem duplication and activating loop mutation in therapy-related acute myelocyticleukemia and myelodysplastic syndrome, Cancer Genetics and Cytogenetics. 2004, 149(2): 169-172.

Chim J.C.S., Fung T.K. and Liang R.H.S., Disruption of INK4/CDK/Rb Cell cycle pathway by gene hypermethylation in multiple myeloma and MGUS., Leukemia. 2003, 76: 169-176.

Chim J.C.S., Kwong Y.L., Fung T.K. and Liang R.H.S., Methylation profiling in multiple myeloma, Leukemia Research. 2004, 28: 379-385.

Chim J.C.S., Fung T.K., Cheung W.C., Liang R.H.S. and Kwong Y.L., SOCS1 and SHP1 Hypermethylation in Multiple Myeloma: Implications for Epigenetic Activation of the Jak/STAT pathway, Blood. 2004, 103: 4630-4635.

Researcher : Gao Z

List of Research Outputs

Du X., Gao Z., Lau C.P., Chiu S.W., Tse H.F., Baumgarten C.M. and Li G.R., Differential effects of tyrosine kinase inhibitors on volume-sensitive chloride current in human atrial myocytes: evidence for dual regulation by Src and EGFR kinases, Journal of General Physiology. 2004, 123: 427-39.

Gao Z., Lau C.P., Chiu S.W. and Li G.R., A novel ionic mechanism of verapamil in human atrial myocytes, Biophysical Journal/48th Biophysical Society, Baltimore, MD, USA. 2004, 86: 719.

Gao Z., Lau C.P., Chiu S.W. and Li G.R., Effects of Verapamil on Transient Outward and Ultra-rapid Delayed Rectifier Potassium Current in Human Atrial Myocytes , Journal of the Hong Kong College of Cardiology/The 7th Annual Meeting, Institute of Cardiovascular Science and Medicine. 2003, 11 (suppl 1): A14.

Gao Z., Lau C.P., Chiu S.W. and Li G.R., Inhibition of ultra-rapid delayed rectifier K+ current by verapamil in human atrial myocytes, Journal of Molecular and Cellular Cardiology . 2004, 36: 257-263.

Gao Z., Lau C.P., Wong T.M. and Li G.R., Protein tyrosine kinase-dependent modulation of voltage-dependent potassium channels by genistein in rat cardiac ventricular myocytes, Cellular Signaling. 2004, 16: 333-341.

Researcher : Gascoyne RD

List of Research Outputs

Au W.Y., Gascoyne R.D., Klasa R.J., Viswanatha D.S., Horsman D.E. and Connors J.M., The spectrum of lymphoma with 8q24 aberrations: a clinical, pathological and cytogenetic study of 87 consecutive cases, Leukemia & lymphoma. 2004, 45: 519-528.

Researcher : Gu Q

List of Research Outputs

Li G., Xia H.H.X., Chen M.H., Peng J., Gu Q., Cui J., Cho C.H., Lam S.K., Lin M.C., Berg D.E., Feng Z., Langenbach R., Kung H. and Wong B.C.Y., Cyclooxygenase-2 Gene Disruption Enhances Gastric Inflammation but Inhibits Gastric Epithelial Proliferation Induced by H. pylori Infection, Gastroenterology. 2004, 126 (4 Suppl 2): W907.

Wang J., Gu Q., Xia H.H.X., Tu S., Peng J., Yang Y., Zou B., Lin M.C., Kung H., Lam S.K. and Wong B.C.Y., JNK1 Up-Regulates the Expression of XIAP-Associated Factor 1 (XAF1) by a P53-Dependent Pathway in Gastrointestinal Cancer, Gastroenterology. 2004, 126 (4 Suppl 2): M946.

Wong W.M., Gu Q., Wang W., Fung F.M.Y., Berg D.E., Lai K.C., Xia H.H.X., Hu H.C., Chan C.K., Chan O.O., Yuen M.F., Hui C.K., Lam S.K. and Wong B.C.Y., Effects of Primary Metronidazole and Clarithromycin Resistance to Helicobacter pylori on Omeprazole, Metronidazole, and Clarithromycin Triple-Therapy Regimen in a Region with High Rates of Metronidazole Resistance, Clinical Infectious Diseases. 2003, 37(7): 882-9.

Yang Y., Lin M.C., Ching Y.P., Lam S.K., Xia H.H.X., Tu S., Zou B., Wang J., Li G., He H., Gu Q., Peng J., Kung H. and Wong B.C.Y., FHL2 As a Co-Factor of XAF1 in the Induction of Apoptosis, Gastroenterology. 2004, 126 (4 Suppl 2): S938.

Researcher : Guo H

List of Research Outputs

Guo H., Leung J.C.K., Chan L.Y., Chan D.T.M. and Lai K.N., The pathogenetic role of immunoglobulin G from patients with systemic lupus erythematosus in the development of lupus pleuritis, Rheumatology. 2004, 43: 286-293.

Researcher : He H

List of Research Outputs

Yang Y., Lin M.C., Ching Y.P., Lam S.K., Xia H.H.X., Tu S., Zou B., Wang J., Li G., He H., Gu Q., Peng J., Kung H. and Wong B.C.Y., FHL2 As a Co-Factor of XAF1 in the Induction of Apoptosis, Gastroenterology. 2004, 126 (4 Suppl 2): S938.

Zou B., Lin M.C., Lam S.K., Tu S., Yang Y., Wang J., He H., Peng J., Kung H. and Wong B.C.Y., Hypermethylation Status Around Exon 1 of XIAP-Associated Factor 1 in Human Gastric and Colon Cancer Cell Lines, Gastroenterology. 2004, 126 (4 Suppl 2): T981.

Researcher : Ho CME

List of Research Outputs

Chung S.S.M., Ho C.M.E., Lam K.S.L., Lam K.S.L. and Chung S.K., Oxidative stress and diabetic complications, The 3rd International Huaxia Congress of Endocrinology, May 25 – 28, 2004, Shanghai, China. 2004.

Researcher : Ho JCM

List of Research Outputs

Chan M.M.W., Lam W.K., Mak J.C.W., Ho S.P., Chan R.H.W., Tsang K.W.T., Ip M.S.M., Ho J.C.M., Wong M.P. and Tan-Un K.C., Polymorphisms of CYP and GST genes, passive smoke and lung cancer risk in Hong Kong Chinese, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-11.

Ho J.C.M., Lam W.K., Yan C.P.K., Ip S., Wong M., Lam J., Wang J., Lam C.L., Lam B., Chan M.M.W., Ip M.S.M. and Tsang K.W.T., A phase II study of vinorelbine monotherapy in the treatment of advanced nob-small cell lung cancer in the elderly, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-06.

Ho J.C.M., Lam W.K., Lam B., Wong M.P. and Tsang K.W.T., Clinical outcome for lymphoepithelioma-like carcinoma of the lung cancer after chemoradiotherapy, Lung Cancer. 2003, 41 (suppl 2): S146.

Ho J.C.M., Wong R.W.M., Ooi C.G.C., Mok T.Y., Hung I.F., Ng W., Lam Y.M., Tam W.O., Wong P.C., Ho P.L., Lai C.L., Lam W.K., Lam S.K. and Tsang K.W.T., Correlation of Liver Dysfunction And Disease Activity In Patients With Severe Acute Respiratory Syndrome, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-08.

Ho J.C.M., Ooi C.G.C., Mok T.Y., Chan J.W., Hung I., Lam B., Wong P.C., Li P.C., Ho P.L., Lam W.K., Ng C.K., Ip M.S.M., Lai K.N., Chan M.M.W. and Tsang K.W.T., High-dose pulse versus nonpulse corticosteroid regimens in severe acute respiratory syndrome, American Journal of Respiratory and Critical Care Medicine. 2003, 168: 1449-1456.

Ho J.C.M., Tipoe G.L., Zheng L., Leung T.M., Tsang K.W.T., Shum D.K.Y., Lau W.C.S., Mak J.C.W., Lam W.K. and Ip M.S.M., In vitro study of regulation of IL-6 production in bronchiectasis, Respiratory Medicine. 2004, 98: 334-341.

Ho J.C.M., Ooi C.G.C., Mok T.Y.M., Ho P.L., Chan M.M.W., Ip M.S.M., Lam W.K. and Tsang K.W.T., Initial pulse or non-pulse steroid therapy in patients with deteriorating severe acute respiratory syndrome, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia,2003. Abstract book PP6-14: p.193.

Ho J.C.M., Lam W.K., Ip S., Wong M. and Chan M.M.W., Local experience in the treatment of advanced lymphoepithelioma-like carcinoma of the lung, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-07.

Ho J.C.M., Lam W.K., Ooi C.G.C., Wong M.P., Lam J.C., Ip M.S.M. and Tsang K.W.T., Lymphoepithelioma-like carcinoma of the lung in a patient with silicosis, European Respiratory Journal . 2003, 22(2): 383-386.

Ho J.C.M., Ho S.P., Chan M.M.W., Mak J.C.W., Ip M.S.M., Wong M.P., Tsang K.W.T. and Lam W.K., Non-small cell lung cancer in Chinese is associated with disturbance in systemic antioxidants profiles , 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-03.

Ho J.C.M., Wu A.Y.Y., Ooi C.G.C., Lam B., Ho P.L., Chan M.M.W., Ip M.S.M., Lam W.K. and Tsang K.W.T., Pentaglobin as rescue therapy in patients with severe acute respiratory syndrome, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-04.

Ho J.C.M., Ooi C.G.C., Mok T.Y., Ho P.L., Chan M.M.W., Ip M.S.M., Lam W.K. and Tsang K.W.T., Pulse corticosteroid therapy in patients with severe acute respiratory syndrome, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-05.

Ho J.C.M., Ho S.P., Chan M.M.W., Ip M.S.M., Wong M.P., Tsang K.W.T. and Lam W.K., Systemic antioxidant profiles in non-small cell lung cancer in Chinese, The Journal of the Japanese Respiratory Society. 2004, 42 (suppl): 69.

Jones B.M., Ma E.S.K., Peiris J.S.M., Wong P.C., Ho J.C.M., Lam B., Lai K.N. and Tsang K.W.T., Prolonged disturbances of in vitro cytokine production in patients with severe acute respiratory syndrome (SARS) treated with ribavirin and steroids, Clinical & Experimental Immunology. 2004, 135: 467-473.

Lam M.F., Ooi C.G.C., Lam B., Ho J.C.M., Seto W.H., Ho P.L., Wong P.C., Liang R.H.S., Lam W.K. and Tsang K.W.T., An indolent case of severe acute respiratory syndrome, American Journal of Respiratory and Critical Care Medicine. 2004, 169(1): 125-128.

Lam W.K., Ho J.C.M., Lam B. and Tsang K.W.T., Severe acute respiratory syndrome (SARS) and impacts on travel, Internal Medicine Journal of Thailand. 2003, 19: 279-286.

Ooi C.G.C., Khong P.L., Lam B., Ho J.C.M., Yiu W.C., Wong R.W.M., Wang T., Ho P.L., Wong P.C., Chan R.H., Lam W.K., Lai K.N. and Tsang K.W.T., Relationship between radiological and clinical parameters in SARS, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia, 2003. Abstract Book: OP2-01, p.73.

Ooi C.G.C., Khong P.L., Muller N.L., Zhou L.J., Ho J.C.M., Lam B., Nicolaou S. and Tsang K.W.T., Sequential HRCT findings in SARS., The 8th Asian Pacific Society of Respirology Congress.. 2003.

Ooi C.G.C., Khong P.L., Lam B., Ho J.C.M., Yiu W.C., Wong R.W.M., Wang T., Ho P.L., Chan R.H., Lam W.K., Lai K.N. and Tsang K.W.T., Severe acute respiratory syndrome : Relationship between radiological and clinical parameters, Radiology. 2003, 229: 492-499.

Ooi C.G.C., Khong P.L., Ho J.C.M., Lam B., Wong R.W.M., Yiu M.W.C., Wong P.C., Wong C.F., Lai K.N. and Tsang K.W.T., Severe acute respiratory syndrome: radiographic evaluation and clinical outcome measures, Radiology. 2003, 229: 500-506.

Ooi C.G.C., Khong P.L., Muller N.L., Yiu W.C., Zhou L.J., Ho J.C.M., Lam B., Nicolaou S. and Tsang K.W.T., Severe acute respiratory syndrome: temporal lung changes at thin-section CT in 30 patients, Radiology. 2004, 230: 836-844.

Tsang K.W.T., Tipoe G.L., Sun J.Z., Mak J.C.W., Leung Y.H., Yan C.P.K., Ko K.W., Ooi C.G.C., Ho P.L., Ho J.C.M. and Lam W.K., Central microtubular ciliary defects are of clinical significance in bronchiectasis, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia. 2003, Abstract Book PP6-20: p.199.

Tsang K.W.T., Tipoe G.L., Sun J.Z., Mak J.C.W., Leung Y.H., Yan C.P.K., Ko K.W., Ooi C.G.C., Ho P.L., Ho J.C.M. and Lam W.K., Ciliary central microtubular orientation is of no clinical significance in bronchiectasis, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia. 2003, Abstract Book PP6-21: p.200.

Tsang K.W.T., Ho P.L., Tan K.C., Ooi C.G.C., Ho J.C.M., Tipoe G.L., Lam W.K. and Chan M.M.W., Efficacy of 12-month treatment with inhaled corticosteroid in bronchiectasis, European Respiratory Journal. 2003, suppl 22(45): P3213.

Wong W.M., Ho J.C.M., Hung I.F., Ng W., Lam Y.M., Tam W.O., Wong B.C.Y., Wong P.C., Lai C.L., Lam W.K., Lam S.K., Tsang K.W.T., Ooi C.G.C., Ho P.L., Mok T. and Chan J., Temporal Patterns of Hepatic Dysfunction and Disease Severity in Patients with SARS, Journal of the American Medical Association Southeast Asia (JAMA). 2003, 290(20): 2663-2665.

Researcher : Ho SL

Project Title:	Search for a new gene in familial amyotrophic lateral sclerosis
Investigator(s):	Dr. Ho S.L., Dr. Fong G.C.Y., Dr. Ramsden D.B.
Department:	Medicine
Source(s) of Funding:	RGC Projects (Block Grant Funded)
Start Date:	07/2003

Abstract:

To carry out more detailed genetic screening of family members and appropriate controls to elucidate whether the theoretical gene and/or any other within this region of the chromosome is associated with the disease; to elucidate expression of this novel protein in healthy human subjects; to investigate whether genetic mutation/s in this gene may be the causal defects in sporadic ALS, which form the large majority of case and for which there is no known cause.

List of Research Outputs

Chan K.H., Cheung R.T.F., Mak W., Au Yeung K.M. and Ho S.L., Cerebral venous thrombosis presenting as unilateral headache plus visual blurring in a man with nephrotic syndrome, Hospital Medicine. 2004, 65: 54-55.

Chan K.H., Cheung R.T.F., Fong G.C.Y., Tsang K.L., Mak W. and Ho S.L., Clinical relevance of hydrocephalus as a presenting feature of tuberculous meningitis., Quarterly Journal of Medicine. . 2003, 96: 643-648.

Chan K.H., Mak W., Tsang K.L., Fong C.Y.G., Cheng T.S., Cheung R.T.F. and Ho S.L., Idiopathic relapsing transverse myelitis: experience of a regional hospital, 9th Medical Research Conference. 2004.

Chan K.H., Cheung R.T.F., Mak W., Fong C.Y.G., Tsang K.L., Cheng T.S. and Ho S.L., Predictive factors for ischemic strokes complicating tuberculous meningitis, Hong Kong Medical Journal. 2004, 10(Suppl 1): 34.

Chan K.H., Ho P.L., Cheung R.T.F., Tsang K.L., Fong G.C.Y., Cheng P.W. and Ho S.L., Tuberculous meningitis with tuberculomata presenting as postpartum pyrexia of unknown origin. , Hospital Medicine. 2003, 64: 306-307.

Cheng T.S., Mak W., Fong C.Y.G., Chan K.H., Ho S.L. and Cheung R.T.F., Clinical relevance of severe initial hypertension in acute intracerebral haemorrhage, Hong Kong Medical Journal. 2004, 10(Suppl 1): 34.

Fong G.C.Y., Mak W., Cheng T.S., Chan K.H., Fong J.K.Y. and Ho S.L., A prevalence study of Epilepsy in HKSAR, China. , Hong Kong Medical Journal. . 2003, 9(4): 252-257.

Mak W., Cheng T.S., Fong C.Y.G., Tsang K.L., Chan K.H., Cheung R.T.F. and Ho S.L., Re-exploring the cerebrospinal fluid (CSF) to serum glucose ratio, 9th Medical Research Conference. 2004.

Yip J.T.H., Lee T.M.C., Ho S.L., Tsang T.K.L. and Li L.S.W., Emotion recognition in patients with idiopathic Parkinson's disease., Movement Disorders. New York, USA, John-Wiley & Sons, Inc, 2003, 18(10): 1115-1122.

Yu Y.L., Fong K.Y., Ho S.L. and Cheung R.T.F., [Total of 18 chapters- contribution about 1/4: preface, four chapters and 2 half-chapters], Neurology in Practice. Hong Kong, Hong Kong University Press, 2003, 3rd edition.

Zheng Z., Li D., Fung P.C.W., Pei Z., Ramsden D...B... and Ho S.L., COX-2-deficient mice are less prone to MPRP-neurotoxicity than wild-type mice, , Molecular Neuroscience. 2003, 14: 1927-1929.

Researcher : Ho SP

List of Research Outputs

Chan M.M.W., Lam W.K., Mak J.C.W., Ho S.P., Chan R.H.W., Tsang K.W.T., Ip M.S.M., Ho J.C.M., Wong M.P. and Tan-Un K.C., Polymorphisms of CYP and GST genes, passive smoke and lung cancer risk in Hong Kong Chinese, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-11.

Ho J.C.M., Ho S.P., Chan M.M.W., Mak J.C.W., Ip M.S.M., Wong M.P., Tsang K.W.T. and Lam W.K., Non-small cell lung cancer in Chinese is associated with disturbance in systemic antioxidants profiles , 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-03.

Ho J.C.M., Ho S.P., Chan M.M.W., Ip M.S.M., Wong M.P., Tsang K.W.T. and Lam W.K., Systemic antioxidant profiles in non-small cell lung cancer in Chinese, The Journal of the Japanese Respiratory Society. 2004, 42 (suppl): 69.

Mak J.C.W., Ho S.P., Tsang K.W.T., Ip M.S.M., Yu W.C., Yew W.W. and Chan M.M.W., Increased transforming growth factor-beta 1 (TGF-beta 1) plasma level in Chinese patients with chronic obstructive pulmonary disease (COPD), American Thoracic Society International Conference, Orlando, USA. May 2004. 169(7): A838.

Researcher : Hu HC

Project Title:	A study to validate a symptom severity questionnaire for patents with functional dyspepsia
Investigator(s):	Dr. Hu W.H.C., Dr. Lam C.L.K.
Department:	Medicine
Source(s) of Funding:	Health Services Research Fund
Start Date:	10/1998

Abstract:

To develop and validate an instrument to measure the severity of symptoms in patients with functional dyspepsia.

List of Research Outputs

Hui C.K., Lai K.C., Yuen M.F., Ng M.M.T., Chan C.K., Hu H.C., Wong R.W.M., Lai C.L. and Wong B.C.Y., Does the Addition of Endoscopic Sphincterotomy to Stent Insertion Improve Drainage of the Bile Duct in Acute Suppurative Cholangitis?, Gastrointestinal Endoscopy. 2003, 58(4): 500-4.

Hui C.K., Liu C.L., Lai K.C., Chan S.C., Hu H.C., Wong R.W.M., Cheung W.W., Ng M.M.T., Yuen M.F., Chan O.O., Lo C.M., Fan S.T. and Wong B.C.Y., Outcome of emergency ERCP for acute cholangitis in patients 90 years of age and older, Alimentary Pharmacology and Therapeutics. 2004, 19(11): 1153-1158.

Lai K.C., Lam S.K., Chu K.M., Hui W.M., Kwok K.F., Wong B.C.Y., Hu H.C., Wong R.W.M., Chan O.O. and Chan C.K., Lansoprazole Reduces Ulcer Relapse after Eradication of Helicobacter pylori in Nonsteroidal Anti-Inflammatory Drug Users--a Randomized Trial, Alimentary Pharmacology and Therapeutics. 2003, 18(8): 829-36.

Wong B.C.Y., Wong R.W.M., Cheung K.L., Tong S.M., Rozen P., Young G.P., Chu K.W., Ho J.W.C., Law W.L., Tung H.M., Lai K.C., Hu H.C., Chan C.K. and Lam S.K., A Sensitive Guaiac Fecal Occult Blood Test is Less Useful than an Immunochemical Test for Colorectal Cancer Screening in a Chinese Population , Alimentary Pharmacology and Therapeutics. 2003, 18(9): 941-946.

Wong B.C.Y., Lam S.K., Wong R.W.M., Chen J.S., Zheng T., Feng R., Lai K.C., Hu H.C., Yuen S.T., Leung S.Y., Fong D.Y.T., Ho J.C.Y., Ching C.K. and Chen J.S., Helicobacter pylori Eradication to Prevent Gastric Cancer in a High-Risk Region of China: a Randomized Controlled Trial, The Journal of American Medical Association. 2004, 291(2): 187-194.

Wong B.C.Y., Lam S.K., Wong R.W.M., Chen J.S., Zheng T., Feng R., Lai K.C., Hu H.C., Yuen S.T., Leung S.Y., Fong D.Y.T., Ho J.W.C. and Ching C.K., Helicobacter pylori eradication to prevent gastric cancer in a high-risk region in China: A randomized controlled trial, JAMA. 2004, 291(2): 187-194.

Wong R.W.M., Lai K.C., Hui W.M., Lam K.F., Huang J., Hu H.C., Wong Y.H., Lam C.L.K., Xia H.H.X., Chan O.O., Lam S.K. and Wong B.C.Y., Double-blind, Randomized Controlled Study to Assess the Effects of Lansoprazole 30 mg and Lansoprazole 15 mg on 24-h Oesophageal and Intragastric pH in Chinese Subjects with Gastro-Oesophageal Reflux Disease, Alimentary Pharmacology and Therapeutics. 2004, 19(4): 455-62.

Wong R.W.M., Lai K.C., Hui W.M., Hu H.C., Huang J., Wong Y.H., Xia H.H.X., Chan O.O., Lam S.K. and Wong B.C.Y., Pathophysiology of Gastro-oesophageal Reflux Diseases in Chinese – Role of Transient Lower Oesophageal Sphincter Relaxation and Oesophageal Motor Dysfunction, Gastroenterology. 2004, 126 (4 Suppl 2): T1724.

Wong R.W.M., Lam K.F., Cheng C., Hui W.M., Xia H.H.X., Lai K.C., Hu H.C., Huang J., Lam C.L.K., Chan C.K., Chan O.O., Lam S.K. and Wong B.C.Y., Population Based Study of Noncardiac Chest Pain in Southern Chinese: Prevalence, Psychosocial Factors and Health Care Utilization, World Journal of Gastroenterology. 2004, 10(5): 707-712.

Wong W.M., Gu Q., Wang W., Fung F.M.Y., Berg D.E., Lai K.C., Xia H.H.X., Hu H.C., Chan C.K., Chan O.O., Yuen M.F., Hui C.K., Lam S.K. and Wong B.C.Y., Effects of Primary Metronidazole and Clarithromycin Resistance to Helicobacter pylori on Omeprazole, Metronidazole, and Clarithromycin Triple-Therapy Regimen in a Region with High Rates of Metronidazole Resistance, Clinical Infectious Diseases. 2003, 37(7): 882-9.

Wong W.M., Lam S.K., Tong S.M., Cheung K.L., Tang V.S.Y., Xia H.H.X., Lai K.C., Hu H.C., Chan C.K., Yuen M.F., Chan O.O. and Wong B.C.Y., Evaluation of a Rapid Stool Antigen Test for the Diagnosis of Helicobacter pylori Infection in Chinese Patients, Chinese Journal of Digestive Diseases. 2003, 4: 132-135.

Wong W.M., Lai K.C., Lam K.F., Hui W.M., Hu H.C., Lam C.L.K., Xia H.H.X., Huang J., Chan C.K., Lam S.K. and Wong B.C.Y., Prevalence, Clinical Spectrum and Health Care Utilization of Gastro-Oesophageal Reflux Disease in a Chinese Population: a Population-Based Study, Alimentary Pharmacology and Therapeutics. 2003, 18(6): 595-604.

Researcher : Huang CY

List of Research Outputs

Ng P.W., Huang C.Y., Cheung R.T.F., Wong K.S., Wong C.K. and Lam J.M., Consensus statements on ischaemic stroke care, Hong Kong Medical Journal. 2004, 10: 124-129.

Researcher : Hui CK

List of Research Outputs

Yuen M.F., Wong D.K.H., Sablon E., Yuan H., Sum S.M., Hui C.K., Wong B.C.Y. and Lai C.L., Hepatitis B Virus Genotypes B and C Do Not Affect the Anti-viral Response to Lamivudine, Hepatology. 2003, 38, No. 4, Suppl. 1: 723A.

Researcher : Hui WM

List of Research Outputs

Chan O.O., Peng J., Lam S.K., Hui W.M., Wong R.W.M., Yuen M.F., Kwong Y.L., Rashid A. and Wong B.C.Y., Reveral of E-Cadherin Promoter Hypermethylation Status after Helicobacter pylori Eradication, Gastroenterology. 2004, 126 (4 Suppl 2): 333.

Cheng C., Chan O.O., Hui W.M. and Lam S.K., Coping Strategies, Illness Perception, Anxiety and Depression of Patients with Idiopathic Constipation: a Population-Based Study, Alimentary Pharmacology and Therapeutics. 2003, 18(3): 319-26.

Lai K.C., Lam S.K., Chu K.M., Hui W.M., Kwok K.F., Wong B.C.Y., Hu H.C., Wong R.W.M., Chan O.O. and Chan C.K., Lansoprazole Reduces Ulcer Relapse after Eradication of Helicobacter pylori in Nonsteroidal Anti-Inflammatory Drug Users--a Randomized Trial, Alimentary Pharmacology and Therapeutics. 2003, 18(8): 829-36.

Wong R.W.M., Hui W.M. and Wong B.C.Y., Asia-Pacific Consensus on Gastroesophageal Reflux Disease, Journal of Gastroenterology and Hepatology. 2004, 19(4): 353-6.

Wong R.W.M., Lai K.C., Hui W.M., Lam K.F., Huang J., Hu H.C., Wong Y.H., Lam C.L.K., Xia H.H.X., Chan O.O., Lam S.K. and Wong B.C.Y., Double-blind, Randomized Controlled Study to Assess the Effects of Lansoprazole 30 mg and Lansoprazole 15 mg on 24-h Oesophageal and Intragastric pH in Chinese Subjects with Gastro-Oesophageal Reflux Disease, Alimentary Pharmacology and Therapeutics. 2004, 19(4): 455-62.

Wong R.W.M., Hui W.M. and Wong B.C.Y., Gastro-Oesophageal Reflux Disease – An Update, Medical Progress. 2003, 30(10): 41-48.

Wong R.W.M., Cheng C., Hui W.M. and Wong B.C.Y., Irritable Bowel Syndrome, Medical Progress. 2003, 30(8): 50-55.

Wong R.W.M., Hui W.M. and Wong B.C.Y., Non-Erosive Reflux Disease, Medical Progress. 2003, 30(11): 41-47.

Wong R.W.M., Lai K.C., Hui W.M., Hu H.C., Huang J., Wong Y.H., Xia H.H.X., Chan O.O., Lam S.K. and Wong B.C.Y., Pathophysiology of Gastro-oesophageal Reflux Diseases in Chinese – Role of Transient Lower Oesophageal Sphincter Relaxation and Oesophageal Motor Dysfunction, Gastroenterology. 2004, 126 (4 Suppl 2): T1724.

Wong R.W.M., Lam K.F., Cheng C., Hui W.M., Xia H.H.X., Lai K.C., Hu H.C., Huang J., Lam C.L.K., Chan C.K., Chan O.O., Lam S.K. and Wong B.C.Y., Population Based Study of Noncardiac Chest Pain in Southern Chinese: Prevalence, Psychosocial Factors and Health Care Utilization, World Journal of Gastroenterology. 2004, 10(5): 707-712.

Wong W.M., Lai K.C., Lam K.F., Hui W.M., Hu H.C., Lam C.L.K., Xia H.H.X., Huang J., Chan C.K., Lam S.K. and Wong B.C.Y., Prevalence, Clinical Spectrum and Health Care Utilization of Gastro-Oesophageal Reflux Disease in a Chinese Population: a Population-Based Study, Alimentary Pharmacology and Therapeutics. 2003, 18(6): 595-604.

Researcher : Hui WS

List of Research Outputs

Mak J.C.W., Hui W.S., Lam W.K. and Tsang K.W.T., Role of pseudomonas aeruginosa pyocyanin in mediating cytokine release in human airway epithelial cells in vitro , 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia. 2003, Abstract Book PP7-05: p.220.

Mak J.C.W., Hui W.S., Pan N.Y., Lam W.K. and Tsang K.W.T., Role of pseudomonas aeruginosa pyocyanin in mediating cytokine release in human airway epithelial cells in vitro, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-02.

Researcher : Ip MSM

Project Title:	Role of cytokines and adhesion molecules in the inflammatory response of bronchiectasis
Investigator(s):	Prof. Ip M.S.M., Prof. Lam W.K., Dr. Shum D.K.Y., Dr. Tsang K.W.T.
Department:	Medicine
Source(s) of Funding:	Lee Wing Tat Cardiothoracic Research and Education Fund
Start Date:	01/1996

Abstract:

To study the profile and actions of cytokines and cell adhesion molecules in the chronic and acute on chronic inflammatory response in bronchiectasis.

Project Title:	Study of the mechanisms of vascular homeostasis in obstructive sleep apnoea
Investigator(s):	Prof. Ip M.S.M., Prof. Kwong Y.L., Prof. Lam W.K., Dr. Tsang K.W.T., Dr. Tse H.F.
Department:	Medicine
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	12/2000

Abstract:

To evaluate some basic mechanisms with a study protocol that examines changes in vascular mediators, platelet activity, vascular reactivity and haemodynamic/breathing profile during sleep in obstructive sleep apnoea (OSA) subjects compared to normal controls as well as in OSA subjects before and after treatment with nasal continuous positive airway pressure (nCPAP).

Project Title:	Role of adiponectin in obstructive sleep apnoea
Investigator(s):	Prof. Ip M.S.M., Dr. Lam J., Prof. Lam K.S.L.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2002

Abstract:

To investigate serum adiponectin levels in OSA patients with a spectrum of body mass index (BMI) and sleep disordered breathing (no OSA to severe OSA) and define correlative parameters; to investigate for any difference in adiponectin levels in patients with OSA and BMI-matched subjects with no OSA (3) the impact of nasal Continuous Positive Airway pressure (nCPAP) treatment on adiponectin secretion in subjects with OSA.

List of Research Outputs

Chan C.H., Shum D.K.Y. and Ip M.S.M., Sputum sol neutrophil elastase activity in bronchiectasis: differential modulation by syndecan-1 , American Journal of Respiratory and Critical Care Medicine. 2003, 168(2): 192-198.

Chan K.S., Zheng J.P., Mok Y.W., Li Y.W., Liu Y.N., Chu C.M. and Ip M.S.M., SARS : prognosis, outcome and sequelae, Respirology. 2003, 8 (suppl): S36-40.

Chan M.M.W., Lam W.K., Mak J.C.W., Ho S.P., Chan R.H.W., Tsang K.W.T., Ip M.S.M., Ho J.C.M., Wong M.P. and Tan-Un K.C., Polymorphisms of CYP and GST genes, passive smoke and lung cancer risk in Hong Kong Chinese, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-11.

Chan M.M.W., Seto W.H., Sung J.J., Lai T.S.T., Yee W., Yam L.Y.C., Tsang K.W.T., Ip M.S.M., Lam W.K. and Lai K.N., Severe Acute Respiratory Syndrome: Patients Were Epidemiologically Linked, British Medical Journal. 2003, 326: 1393.

Chan M.M.W., Ait-Khaled N., White N., Ip M.S.M. and Tan W.C., The burden and impact of COPD in Asia an Africa., International Journal of Tuberculosis and Lung Disease. 2004, 8(1): 2-14.

Ho J.C.M., Lam W.K., Yan C.P.K., Ip S., Wong M., Lam J., Wang J., Lam C.L., Lam B., Chan M.M.W., Ip M.S.M. and Tsang K.W.T., A phase II study of vinorelbine monotherapy in the treatment of advanced nob-small cell lung cancer in the elderly, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-06.

Ho J.C.M., Ooi C.G.C., Mok T.Y., Chan J.W., Hung I., Lam B., Wong P.C., Li P.C., Ho P.L., Lam W.K., Ng C.K., Ip M.S.M., Lai K.N., Chan M.M.W. and Tsang K.W.T., High-dose pulse versus nonpulse corticosteroid regimens in severe acute respiratory syndrome, American Journal of Respiratory and Critical Care Medicine. 2003, 168: 1449-1456.

Ho J.C.M., Tipoe G.L., Zheng L., Leung T.M., Tsang K.W.T., Shum D.K.Y., Lau W.C.S., Mak J.C.W., Lam W.K. and Ip M.S.M., In vitro study of regulation of IL-6 production in bronchiectasis, Respiratory Medicine. 2004, 98: 334-341.

Ho J.C.M., Ooi C.G.C., Mok T.Y.M., Ho P.L., Chan M.M.W., Ip M.S.M., Lam W.K. and Tsang K.W.T., Initial pulse or non-pulse steroid therapy in patients with deteriorating severe acute respiratory syndrome, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia,2003. Abstract book PP6-14: p.193.

Ho J.C.M., Lam W.K., Ooi C.G.C., Wong M.P., Lam J.C., Ip M.S.M. and Tsang K.W.T., Lymphoepithelioma-like carcinoma of the lung in a patient with silicosis, European Respiratory Journal . 2003, 22(2): 383-386.

Ho J.C.M., Ho S.P., Chan M.M.W., Mak J.C.W., Ip M.S.M., Wong M.P., Tsang K.W.T. and Lam W.K., Non-small cell lung cancer in Chinese is associated with disturbance in systemic antioxidants profiles , 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-03.

Ho J.C.M., Wu A.Y.Y., Ooi C.G.C., Lam B., Ho P.L., Chan M.M.W., Ip M.S.M., Lam W.K. and Tsang K.W.T., Pentaglobin as rescue therapy in patients with severe acute respiratory syndrome, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-04.

Ho J.C.M., Ooi C.G.C., Mok T.Y., Ho P.L., Chan M.M.W., Ip M.S.M., Lam W.K. and Tsang K.W.T., Pulse corticosteroid therapy in patients with severe acute respiratory syndrome, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-05.

Ho J.C.M., Ho S.P., Chan M.M.W., Ip M.S.M., Wong M.P., Tsang K.W.T. and Lam W.K., Systemic antioxidant profiles in non-small cell lung cancer in Chinese, The Journal of the Japanese Respiratory Society. 2004, 42 (suppl): 69.

Ip M.S.M., Lam B., Tang L.C., Lauder I.J., Ip T.Y. and Lam W.K., A community study of sleep-disordered breathing in middle-aged Chinese women in Hong Kong - prevalence and gender differences, Chest. 2004, 125: 127-134.

Ip M.S.M., Cardiovascular morbidity in sleep breathing disordered, 8th Congress of Asian Pacific Society of Respirology, Kuala Lumpur, Malaysia. 2003, Abstract Book: Symposium SIB-3, p.9.

Ip M.S.M., Tse H.F., Lam B., Tsang K.W.T. and Lam W.K., Endothelial function in obstructive sleep apnea and response to treatment, American Journal of Respiratory and Critical Care Medicine. 2004, 169: 348-353.

Ip M.S.M., Hypersomnolence, 10th Annual Scientific Meeting, Hong Kong Society of Sleep Medicine, September 2003. 2003.

Lam B., Ooi C.G.C., Peh W.C.G., Lauder I.J., Tsang K.W.T., Lam W.K. and Ip M.S.M., Computed tomographic evaluation of the role of craniofacial and upper airway morphology obstructive sleep apnea in Chinese, Respiratory Medicine. 2004, 98: 301-307.

Lam B., Ooi C.G.C., Wong M.P., Lee R., Ip M.S.M., Chan M.M.W., Lam W.K. and Tsang K.W.T., Extrapulmonary presentation of asymptomatic pulmonary lymphangioleiomyomatosis, Respirology. 2003, 8(4): 544-547.

Lam K.S.L., Xu A., Wat N.M.S., Tso A.W.K. and Ip M.S.M., Obesity as the key player in the Metabolic Syndrome, 13th International Symposium on Atherosclerosis, September 28 – October 2, 2003, Kyoto, Japan.. 2003.

Lam K.S.L., Xu A., Wat N.M.S., Tso A.W.K. and Ip M.S.M., Obesity as the key player in the metabolic syndrome, International Congress Series. 2004, 1262: 542-5.

Mak J.C.W., Ho S.P., Tsang K.W.T., Ip M.S.M., Yu W.C., Yew W.W. and Chan M.M.W., Increased transforming growth factor-beta 1 (TGF-beta 1) plasma level in Chinese patients with chronic obstructive pulmonary disease (COPD), American Thoracic Society International Conference, Orlando, USA. May 2004. 169(7): A838.

Mok W.Y.W., Lam C.L.K., Lam B., Cheung M.T., Yam L.Y.C. and Ip M.S.M., A Chinese version of the Sleep Apnea Quality of Life Index : reliability, validity and responsiveness, Journal of Clinical Epidemiology. 2004, 57(5): 470-478.

Ooi C.G.C., Tsang K.W.T., Cheung R.T.F., Khong P.L., Ho I.W.T., Ip M.S.M., Tan C.M., Ngan H., Lam W.K., Chan F.L. and Chan M.M.W., Silicosis in 76 men: qualitative and quantitative CT evaluation - clinical-radiologic correlative study., Radiology . 2003, 228(3): 816-25.

Shum D.K.Y. and Ip M.S.M., Degradation of lung matrix proteoglycans in bronchiectasis, In: HG Garg, PJ roughley and CA Hales , Proteoglycans and Lung Disease in "Lung Biology in Health and Disease" Series. New York, Marcel Dekker, 2003, 323-333.

Wat A.L.O., Shum D.K.Y. and Ip M.S.M., Characterization of heparan sulphate proteoglycan recovered from cultures pf human bronchial epithelial cells, 8th Research Postgraduate Symposium, Faculty of Medicine, HKU. 2003, Abstract Book: p.68.

Wong M.P., Tipoe G.L., Sun J.Z., Mak J.C.W., Ooi C.G.C., Ip M.S.M., Chan M.M.W., Lam W.K. and Tsang K.W.T., Clinical significance of ciliary abnormalities in bronchiectasis, Annual Scientific Meeting, Hong Kong Thoracic Society & American College of Chest Physicians, 2003. Abstract pp.30.

Wu A.Y.Y., Ooi C.G.C., Lam B., Mok T.Y.M., Ho P.L., Chan M.M.W., Ip M.S.M., Lam W.K. and Tsang K.W.T., The use of pentaglobin in patients with deteriorating severe acute respiratory syndrome, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia . 2003, Abstract Book PP6-15: p.194.

Researcher : Jiang X

List of Research Outputs

Jiang X. and Wong B.C.Y., Cyclooxygenase-2 Inhibition and Gastric Cancer, Current Pharmaceutical Design. 2003, 9(27): 2281-8.

Tu S., Chan O.O., Lin M.C., Jiang X., Lam S.K., Kung H. and Wong B.C.Y., Livin, a Novel Member of Inhibitor of Apoptosis, Is Marker of Poor Prognosis in Gastric Cancer, Gastroenterology. 2004, 126 (4 Suppl 2): T1256.

Tu S., Jiang X., Lin M.C., Cui J., Yang Y., Lum C.T., Zou B., Zhu Y.B., Jiang S.H., Wong W.M., Chan O.O., Yuen M.F., Lam S.K., Kung H. and Wong B.C.Y., Suppression of Survivin Expression Inhibits in vivo Tumorigenicity and Angiogenesis in Gastric Cancer, Cancer Research. 2003, 63(22): 7724-7732.

Wong B.C.Y., Jiang X., Lin M.C., Tu S., Cui J., Jiang S.H., Wong R.W.M., Yuen M.F., Lam S.K. and Kung H., Cyclooxygenase-2 Inhibitor (SC-236) Suppresses Activator Protein-1 through c-Jun NH2-Terminal Kinase, Gastroenterology. 2004, 126: 136-147.

Researcher : Jin C

List of Research Outputs

Zhang H., Tsao G.S.W., Jin C., Stromback B., Yuen P.W., Kwong Y.L. and Jin Y., Sequential Cytogenetic and Molecular Cytogenetic Characterization of an SV40T Immortalized Nasopharyngeal Cell Line transformed by Epstein-Barr virus latent membrane protein-1 gene, Cancer Genetics and Cytogenetics . 2004, 150: 144-52.

Researcher : Jin O

List of Research Outputs

Jin O., Tan K.C., Yeung J.S.L., Tam S.C.F. and Lau W.C.S., Influence on hyperlipidaemia on macrophage phagocytosis of apoptotic cells, 7th International Congress on SLE & Related Conditions, New York. 2004.

Jin O., Sun L.Y., Zhou K.X., Zhang X.S., Feng X.B., Mok T.M.Y. and Lau W.C.S., Lymphocyte apoptosis and macrophage function correlation with disease activity in systemic lupus erythematosus, 7th International Congress on SLE & Related Conditions, New York. 2004.

Jin O., Sun L., Zhou K., Zhan X., Mok T.M.Y. and Lau W.C.S., Lymphocyte apoptosis, macrophage function and disease activity in systemic lupus erythematosus, Annals of the Rheumatic Diseaes, The EULAR Journal. 2003, 62(suppl I): 198.

Jin O., Chan W.K., Mok T.M.Y., Sun L.Y. and Lau W.C.S., Serum levels of osteopontin and matrix metalloproteinase-3 in systemic lupus erythematosus (SLE), 7th International Congress on SLE & Related Conditions, New York. 2004.

Mok T.M.Y., Yeung J.S.L., Jin O., Chan W.K., Lo Y. and Lau W.C.S., Anti-beta2 glycoprotein I antibodies facilitates phagocytosis of apoptotic neutrophils in patients with systemic lupus erythematosus, The Hong Kong Practitioner. 2003, 9(Suppl 1): 65.

Sun L.Y., Gu N.Y., Jin O. and Lau W.C.S., Biological characteristics and hematopoietic cytokine expression of human bone marrow-derived mesenchymal stem cells in systemic lupus erythematosus, 7th International Congress on SLE & Related Condition, New York. 2004.

Researcher : Jin Y

Project Title:	Cytogenetic and molecular genetic characterization of esophageal carcinomas
Investigator(s):	Dr. Jin Y.S., Prof. Kwong Y.L., Prof. Tsao G.S.W.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	10/2002

Abstract:

To identify, by cytogenetic, fluorescence in situ hybridization (FISH), and molecular genetic approaches, the genetic changes that are important in the malignant transformation of esophageal epithelium; to investigate genetic differences and similarity between immortalized, preneoplastic esophageal epithelial cells and aquamous cell carcinoma (SCC) of the esophagus.

List of Research Outputs

Jin Y., Zhang H., Tsao G.S.W., Jin C., Lv M., Strombeck B., Wiegant J., Wan T.S.K., Yuen P.W. and Kwong Y.L., Cytogenetic and molecular genetic characterization of immortalized human ovarian surface epithelial cell lines: consistent loss of chromosome 13 and amplification of chromosome 20, Gynecologic Oncology. 2004, 92: 183-191.

Zhang H., Tsao G.S.W., Jin C., Stromback B., Yuen P.W., Kwong Y.L. and Jin Y., Sequential Cytogenetic and Molecular Cytogenetic Characterization of an SV40T Immortalized Nasopharyngeal Cell Line transformed by Epstein-Barr virus latent membrane protein-1 gene, Cancer Genetics and Cytogenetics . 2004, 150: 144-52.

Researcher : Ko KW

List of Research Outputs

Tsang K.W.T., Tipoe G.L., Sun J.Z., Mak J.C.W., Leung Y.H., Yan C.P.K., Ko K.W., Ooi C.G.C., Ho P.L., Ho J.C.M. and Lam W.K., Central microtubular ciliary defects are of clinical significance in bronchiectasis, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia. 2003, Abstract Book PP6-20: p.199.

Tsang K.W.T., Tipoe G.L., Sun J.Z., Mak J.C.W., Leung Y.H., Yan C.P.K., Ko K.W., Ooi C.G.C., Ho P.L., Ho J.C.M. and Lam W.K., Ciliary central microtubular orientation is of no clinical significance in bronchiectasis, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia. 2003, Abstract Book PP6-21: p.200.

Tsang K.W.T., Tipoe G.L., Sun J.Z., Mak J.C.W., Leung Y.H., Yan C.P.K., Ko K.W., Ooi C.G.C. and Lam W.K., Clinical significance of ciliary abnormalities in bronchiectasis, European Respiratory Journal. 2003, suppl 22(45): P559.

Researcher : Kou M

List of Research Outputs

Au W.Y., Kumana C.R., Kou M., Mak R., Chan G.C.F., Lam C.W. and Kwong Y.L., Oral arsenic trioxide in the treatment of relapsed acute promyelocytic leukemia, Blood. Washington, American Society of Hematology, 2003, 102(1): 407-408.

Kumana C.R., Au W.Y., Lee N.S., Kou M., Mak R.W.M., Lam C.W. and Kwong Y.L., Bioavailability of arsenic trioxide solubalised for oral administration to patients with haemic malignancies (P-11), In: FC Tuluney, M Orme, Sixth Congress of European Association of Clinical Pharmacology adn Therapeutics - European Collaboration: Towards Drug Development and Rational Drug Therapy. 2003, 73.

Kumana C.R., Tong M.K.L., Li C.S., Lauder I.J., Lee J.S.K., Kou M., Walley T., Haycox A. and Chan D.T.M., Diltiazem co-treatment in renal transplant patients receiving microemulsion cyclosporin, British Journal of Clinical Pharmacology. Blackwell Publishing, 2003, 56(6): 670-678.

Researcher : Kumana CR

List of Research Outputs

Ambekar C.S., Kumana C.R., Liang R.H.S. and Cheung B.M.Y., Chloramphenicol succinate as a competitive substrate and inhibitor of succinate dehydrogenase: relation to its mechanisms of toxicity, Hong Kong Medical Journal. 2003, 9(1) Suppl: 64.

Ambekar C.S., Lee J.S.K., Cheung B.M.Y., Chan L.C., Liang R.H.S. and Kumana C.R., Chloramphenicol succinate, a competitive substrate and inhibitor of succinate dehdrogenase : possible reason for its toxicity., Toxicology in Vitro. 2004, 18: 441-447.

Ambekar C.S., Kumana C.R., Liang R.H.S. and Cheung B.M.Y., Traditional Chinese medicine: effect on bone marrow and peripheral blood cell counts and enzyme induction, Hong Kong Medical Journal. 2003, 9(1) Suppl: 63.

Au W.Y., Kumana C.R., Kou M., Mak R., Chan G.C.F., Lam C.W. and Kwong Y.L., Oral arsenic trioxide in the treatment of relapsed acute promyelocytic leukemia, Blood. Washington, American Society of Hematology, 2003, 102(1): 407-408.

Cheung B.M.Y., Lau C.P. and Kumana C.R., Combination therapy for hypertension, Hong Kong Medical Journal. 2003, 9: 224-6.

Cheung B.M.Y., Lauder I.J. and Kumana C.R., Effectiveness and Safety of Statins Reappraised: Updated Meta-Analysis with 5 New Trials (P17), Seventh Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine: Journal of the Hong Kong College of Cardiology. 2003, 11 (Suppl 1).

Cheung B.M.Y. and Kumana C.R., Effectiveness of lipid lowering drugs in general practice: study had two major flaws, British Medical Journal. London, BMJ Publishing Group, 2003, 347(7405): 51.

Cheung B.M.Y., Lam T.H., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Man Y.B., Cheng C.H., Kumana C.R. and Lau C.P., Follow Up of the Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort (CP17), Seventh Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine: Journal of the Hong Kong College of Cardiology . 2003, 11 (Suppl 1).

Cheung B.M.Y., Lam T.H., Lam K.S.L., Tam S.C.F., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Man Y.B., Cheng C.H., Kumana C.R. and Lau C.P., Follow up of the Hong Kong Cardiovascular risk factor prevalence survey cohort, Hong Kong Medical Journal. 2003, 9(1) Suppl: 27.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., High blood pressure is related to obesity in Hong Kong, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., High blood pressure is related to obesity in Hong Kong, Hong Kong Medical Journal. 2003, 9(1) Suppl: 35.

Cheung B.M.Y., Hwang I.S.S., Li Y.Y., O W.S., Tsang K.W.T., Leung Y.H., Kumana C.R. and Tang F., Increased adrenomedullin expression in lungs in endotoxaemia, Journal of Endocrinology. Bristol, Society for Endocrinology, 2004, 181(2): 339-345.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Lipid profile of the Hong Kong cardiovascular risk factor prevalence study cohort, Hong Kong Medical Journal. 2003, 9(1) Suppl: 22.

Cheung B.M.Y., Man Y.B., Lam K.S.L., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Lipid profile of the Hong Kong cardiovascular risk factor prevalence survey cohort, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Cheung B.M.Y., Lauder I.J., Lau C.P. and Kumana C.R., Meta-analysis of large randomized controlled trials to evaluate the impact of statins on cardiovascular outcomes, British Journal of Clinical Pharmacology. Blackwell Publishing, 2004, 57(5): 640-651.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Obesity in the Hong Kong cardiovascular risk factor prevalence survey-2 (CRISPS2) cohort, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Cheung B.M.Y., Man Y.B., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of Diabetes Mellitus (DM) in the Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort (P16), Seventh Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine: Journal of the Hong Kong College of Cardiology . 2003, 11 (Suppl 1).

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of diabetes mellitus (DM) in the Hong Kong Cardiovascular risk factor prevalence study cohort, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Cheung B.M.Y., Man Y.B., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of diabetes mellitus (DM) in the Hong Kong Cardiovascular risk factor prevalence study cohort, Hong Kong Medical Journal. 2003, 9(1) Suppl: 19.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of obesity in the Hong Kong Cardiovascular risk factor prevalence survey-2 (CRISPS2), Hong Kong Medical Journal. 2003, 9(1) Suppl: 23.

Cheung B.M.Y., Law C.Y., Ho G.Y.Y., Ng P.P.Y., Kumana C.R. and Lau C.P., Randomised Controlled Trial of Low Salt Diet in the Treatment of Hypertension (P-229), In: FC Tuluney, M Orme, Sixth Congress of European Association of Clinical Pharmacology adn Therapeutics - European Collaboration: Towards Drug Development and Rational Drug Therapy. 2003, 132.

Cheung B.M.Y., Law C.Y., Fung P.C.W., Tsang K.W.T., Tan K.C.B., Kumana C.R. and Lau C.P., Randomised Trial of Candesartan and Enalapril (RACE) in the treatment of hypertension (P-215), In: FC Tuluney, M Orme, Sixth Congress of European Association of Clinical Pharmacology adn Therapeutics - European Collaboration: Towards Drug Development and Rational Drug Therapy . 2003, 128.

Cheung B.M.Y., Law C.Y., Ho G.Y.Y., Ng P.P.Y., Kumana C.R. and Lau C.P., Randomised controlled trial of low salt diet in the treatment of hypertension, Hong Kong Medical Journal. 2003, 9(1) Suppl: 23.

Cheung B.M.Y., Law C.Y., Fung P.C.W., Tsang K.W.T., Tan K.C.B., Kumana C.R. and Lau C.P., Randomised trial of candesartan and enalapril (RACE) in the treatment of hypertension-final results, Hong Kong Medical Journal. 2003, 9(1) Suppl: 24.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Relationship between Hypertension and Obesity in Hong Kong, 3rd Asian-Pacific Congress of Hypertension. 2004.

Cheung B.M.Y., Leung Y.H., Wong L.Y.F., Man Y.B., Lau C.P. and Kumana C.R., Urotensin II in hypertension, Hong Kong Medical Journal. 2003, 9(1) Suppl: 24.

Cheung G.T.Y., Lau W.C.S. and Kumana C.R., Phosphodiesterase-5 inhibitors relieve symptoms of severe Raynaud's phenomenon, The European League Against Rheumatism (EULAR) Annual Congress for Rheumatology, Berlin, Germany. 2004.

Cheung T.Y.G., Yuen W.H., Kwong Y.L., Au W.Y., Man R.Y.K., Wong W.I. and Kumana C.R., Monitoring blood arsenic in outpatients with acute promyelocytic leukemia receiving oral arsenic trioxide, The 9th Southeast Asian-Western Pacific Regional Meeting of Pharmacologists. 2003, 7, Suppl. 1: 99.

Kumana C.R., Au W.Y., Lee N.S., Kou M., Mak R.W.M., Lam C.W. and Kwong Y.L., Bioavailability of arsenic trioxide solubalised for oral administration to patients with haemic malignancies (P-11), In: FC Tuluney, M Orme, Sixth Congress of European Association of Clinical Pharmacology adn Therapeutics - European Collaboration: Towards Drug Development and Rational Drug Therapy. 2003, 73.

Kumana C.R., Changing Strategy Toward Long-term Management of Atrial Fibrillation, The forth congress of the asian pacific society of atherosclerosis and vascular diseases . 2004.

Kumana C.R., Tong M.K.L., Li C.S., Lauder I.J., Lee J.S.K., Kou M., Walley T., Haycox A. and Chan D.T.M., Diltiazem co-treatment in renal transplant patients receiving microemulsion cyclosporin, British Journal of Clinical Pharmacology. Blackwell Publishing, 2003, 56(6): 670-678.

Kumana C.R., Cheung B.M.Y. and Lauder I.J., Rhythm Control for Atrial Fibrillation Reanalysed by NNT, 8th International Workshop on Cardiac Arrhythmias . 2003.

Kumana C.R., Cheung G.T.Y., Lauder I.J. and Chan L.S., Screening for Fever by Means of Infrared Thermographic Camera (S110), 11th Ineternational Congress of infectious diseases – Mexico 2004: International Journal of Infectious Diseases. 2004, 8 (Suppl 1).

Kumana C.R., Cheung B.M.Y. and Lauder I.J., The burden of rate control in atrial fibrillation, Journal of Cardiovascular Pharmacology and Therapeutics. 2003, 8(3): 247-248.

Lee N., Yuen K.Y. and Kumana C.R., Clinical role of beta-lactam/beta-lactamase inhibitor combinations, Drugs. Adis International, 2003, 63(14): 1511-24.

Man Y.B., Cheung B.M.Y., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of hypertension in the Hong Kong cardiovascular risk factor prevalence study cohort, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Pederson B., Cheung B.M.Y., Lauder I.J. and Kumana C.R., Rhythm Control of Atrial Fibrillation Analysed by Number Needed to Treat (P19), Seventh Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine: Journal of the Hong Kong College of Cardiology . 2003, 11 (Suppl 1).

Researcher : Kung AWC

Project Title:	To determine the factors affecting the rate of bone loss in southern Chinese
Investigator(s):	Prof. Kung A.W.C., Dr. Ho A.Y.Y., Prof. Tang G.W.K.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2002

Abstract:

To measure the rate of bone loss in southern Chinese men and women aged between 45 to 70 by measure BMD at baseline and 2 years later; to determine the environmental and demographic factors that affect the rate of bone loss in southern Chinese men and women; to determine the association of collagen Ia1 gene, estrogen receptor a and b gene with bone mineral density and rate of bone loss in southern Chinese men and women.

Project Title:	Evaluation of maternal and fetal modulators in the development of postpartum autoimmune thyroiditis in a murine model of experimental autoimmune thyroiditis induced by thyroid peroxidase
Investigator(s):	Prof. Kung A.W.C., Prof. Banga J.P.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2003

Abstract:

To determine the incidence of pregnancy outcome in a murine model of AITD induced by immunizing C57B/6(H2[b]) mice with homologous mouse TPO, and to determine the pathogenicity of anti-TPO Ab against placental and fetal antigen; to determine the severity of postpartum thyroiditis in allogeneic C57B/6(H2[b]) x CBA/J(H2[d]) versus synergeneic C57B/6(H2[b]) x C57B/6(H2[b]) and CBA/J(H2[d]) x CBA/J(H2[d]) animals; to determine the cytokine profile in the above animals during pregnancy and postpartum period

List of Research Outputs

But B., Chan C.W., Chan F., Chan K.W., Cheng A.W.F., Cheung P., Choi K.L., Chow C.B., Chow F.C.C., Eastman C., Fok T.F., Fung L.M., Gomes C., Huen K.F., Ip T.P., Kung A.W.C., Lam K.S.L., Lam Y.Y., Lao T.T.H., Lee C.Y., Lee K.F., Leung J., Leung N.K., Li D., Li J., Lo K.W., Low L.C.K., Ng K.L., Siu S.C., Tam S.C.F., Tan K.C.B., Tiu S.C., Tse H.Y., Tse W., Wong G., Wong S., Wong W., Yeung V.T.F., Young R., Yu C.M. and Yu R., Consensus statement on iodine deficiency disorders in Hong Kong, Hong Kong Medical Journal. 2003, 9: 446-453.

Cheung E.Y.N., Ho A.Y.Y., Lam K.F., Tam S.C.F. and Kung A.W.C., Bioavailable testosterone is a risk factor for osteoporotic fracture while bioavailable estradiol is a risk factor for low bone mineral density in men, ENDO 2004, The Endocrine Society’s 86th Annual Meeting, June 16-19, 2004 New Orleans, USA. 2004, P2-53.

Cheung E.Y.N., Ho A.Y.Y. and Kung A.W.C., Lifestyle and hormonal predictors of bone mineral density in Asian men, 25th Annual Meeting of the American Society for Bone and Mineral Research, 19-23 September 2003, Minnesota, USA. Journal of Bone and Mineral Research . 2003, 18(Suppl 2): M288.

Cheung E.Y.N., Ho A.Y.Y. and Kung A.W.C., Lifestyle and hormonal risk factors for bone mineral density in Chinese men, 2nd Asian Regional International Osteoporosis Foundation Conference on Osteoporosis, 16-18 January 2004, Hong Kong. 2004.

Ho A.Y.Y. and Kung A.W.C., Determinants of peak bone bass in Southern Chinese women, 2nd Asian Regional International Osteoporosis Foundation Conference on Osteoporosis, 16-18 January 2004, Hong Kong. 2004.

Ip T.P., Lam C.L.K. and Kung A.W.C., Awareness and pattern of management of osteoporosis among medical practitioners in Hong Kong, 2nd Asian Regional International Osteoporosis Foundation Conference on Osteoporosis, 16-18 January 2004, Hong Kong. 2004.

Ip T.P., Lam C.L.K. and Kung A.W.C., Awareness of osteoporosis among physicians in China, Osteoporosis International . 2004, 15(4): 329-34.

Khan A.A., Bilezikian J.P., Kung A.W.C., Ahmed M.M., Dubois S.J., Ho A.Y.Y., Shaikh A., Rubin M., Silverberg S.J., Standish T.I. and Syed Z.A., A double blind randomized placebo controlled trial of alendronate in primary hyperparathyroidism, 25th Annual Meeting of the American Society for Bone and Mineral Research, 19-23 September 2003, Minnesota, USA. Journal of Bone and Mineral Research . 2003, 18(Suppl 2): F421.

Kung A.W.C., In: Mazzaferri EL (ed), 2003 Year Book of Endocrinology. The effect of pregnancy on thyroid nodule formation. Mosby-Year Book, Inc., 2003.

Kung A.W.C., Ip T.P., Leung J., Lee G. and Ho A.Y.Y., A multi-centered, randomized, double-blind placebo controlled study of risedronate on bone mineral density and bone turnover markers in osteoporotic Chinese women, IOF World Congress on Osteoporosis, 14-18 May 2004, Rio de Janeiro, Brazil. Osteoporosis International . 2004, 15(Supl 1): S96.

Kung A.W.C., Ip T.P., Leung J. and Lee G., A multi-centred, randomized, double-blind placebo controlled study of risedronate on bone mineral density and bone turnover markers in osteoporotic Chinese women, 2nd Asian Regional International Osteoporosis Foundation Conference on Osteoporosis, 16-18 January 2004, Hong Kong . 2004.

Kung A.W.C., Lau K.S. and Chan V.N.Y., Association of a novel single nucleotide polymorphism in the calcium channel a subunit gene (Cav1.1) and thyrotoxic periodic paralysis, Journal of Clinical Endocrinology & Metabolism. 2004, 89(3): 1340-5.

Kung A.W.C., Ng M.Y.M., Lau H.L., Paterson A.D., Bulman D., Luk K.D.K. and Chan V.N.Y., Association of low bone mineral density to microsatellite marker on chromosome 16 in Southern Chinese families, 4th International Meeting on the Genetic Epidemiology of complex Traits, 4-7 April 2004, Churchill College, Cambridge, UK. 2004.

Kung A.W.C., Lau K.S., Fong C.Y. and Chan V.N.Y., Association of novel single-nucleotide polymorphisms in the dihydropyridine sensitive L-type a-3 calcium channel (CACNL1a3) and thyrotoxic periodic paralysis (TPP) , American thyroid Association 75th Annual Meeting, 16-21 September 2003, Palm Beach, USA. Thyroid. 2003, 13(7): 672.

Kung A.W.C., Biochemical Bone Markers – How useful are they?, 4th Annual Meeting of the Malaysia Society of Osteoporosis, 17-19 October 2003, Penang, Malaysia. 2003.

Kung A.W.C., Ho A.Y.Y., Sedrive W.B., Reginster J.Y. and Ross P.D., Comparison of a simple clinical risk index and quantitative bone ultrasound for identifying women at increased risk of osteoporosis, Osteoporosis International. 2003, 14: 716-21.

Kung A.W.C., Determinants of Bone Mass (Plenary Lecture), 3rd International Huaxia Congress of Endocrinology, 25 - 27 May, Shanghai, China. 2004.

Kung A.W.C., Chao H.T., Huang K.E., Need A.G., Taechakraichana N., Loh F.H., Gonzaga F., Sriram U., Ismail N.M., Farooqi A., Rachman I.A., Crans G.G., Wong M. and Thiebaud D., Efficacy and safety of raloxifene 60 milligrams/day in postmenopausal Asian women, Journal of Clinical Endocrinology and Metabolism. 2003, 88(7): 3130-3136.

Kung A.W.C., Epidemiology and diagnostic approaches to vertebral fractures in Asia (Review), Journal of Bone and Mineral Metabolism. 2004, 22(3): 170-5.

Kung A.W.C., Epidemiology of Osteoporosis, 4th Annual Meeting of the Malaysia Society of Osteoporosis, 17-19 October 2003, Penang, Malaysia. 2003.

Kung A.W.C. and Ng H.P., Evidence for intermolecular B-cell epitope spreading from TPO to Tg in a murine EAT model induced with recombinant mouse thyroperoxidase, ENDO 2004, The Endocrine Society’s 86th Annual Meeting, June 16-19, 2004 New Orleans, USA. 2004, P2-500.2.

Kung A.W.C., Heritability of Bone Mass in Chinese (Plenary Lecture), International Meeting on Osteoporosis and Bone Mineral Research, 10-14 October 2003, Beijing, China. 2003.

Kung A.W.C., How to Improve Your Bone Health, Annual Meeting of Chinese Medical Association. 2004.

Kung A.W.C., Iodine Insufficiency in Hong Kong, International Council for the Control of Iodine Deficient Disease Conference, 1 December 2003, Singapore. 2003.

Kung A.W.C., Long Term Efficacy of Bisphosphonates, St Paul’s Doctors Association Meeting. 2004.

Kung A.W.C., Thyroid Antibodies in Pregnancy, 12th Asian-Oceania thyroid Congress, 3-4 December 2003, Singapore. 2003.

Kung A.W.C., Treatment Strategy of Osteoporosis, Hong Kong Orthopaedic Forum. 2004.

Kung A.W.C., Treatment of Osteoporosis: An Update, Hong Kong Doctors Union Meeting. 2003.

Kung A.W.C., 骨質疏鬆症預防與治療, 2003.

Lau H.L., Ho A.Y.Y., Luk K.D.K. and Kung A.W.C., Association of 12 genetic loci and environmental risk factors with bone mineral density in Chinese, 2nd Asian Regional International Osteoporosis Foundation Conference on Osteoporosis, 16-18 January 2004, Hong Kong . 2004.

Lau H.L., Ho A.Y.Y., Luk K.D.K. and Kung A.W.C., Genetic and envorinmental determinants of bone mineral density in Chinese women, 25th Annual Meeting of the American Society for Bone and Mineral Research, 19-23 September 2003, Minnesota, USA. Journal of Bone and Mineral Research . 2003, 18(Suppl 2): M126.

Lau H.L., Ho A.Y.Y., Luk K.D.K. and Kung A.W.C., Site and age specificity of genetic and environmental determinants of bone mineral density, 8th Research Postgraduate Symposium organised by the Faculty of Medicine, The University of Hong Kong, Hong Kong, December 13, 2003.

Lau H.L., Paterson A., Luk K.D.K. and Kung A.W.C., Test of linkage and/or association of genes and bone mineral density in Chinese, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.. 2004.

Lau H.L., Ho A.Y.Y., Luk K.D.K. and Kung A.W.C., Transforming growth factor-b1 gene polymorphisms and bone turnover, bone mineral density and fracture risk in Southern Chinese women , Calcified Tissue International. 2004, online.

Lo C.Y., Chan W.F., Kung A.W.C., Lam K.Y., Tam S.C.F. and Lam K.S.L., Surgical treatment for primary hyperparathyroidism in Hong Kong: Changes in clinical pattern over 3 decades, Archives of Surgery. 2004, 139(1): 77-82.

Ng H.P., Bang J.P. and Kung A.W.C., Development of a murine model of autoimmune thyroiditis induced with homologous mouse thyroid peroxidase, Endocrinology . 2004, 145(2): 809-16.

Ng H.P. and Kung A.W.C., Promiscuous thymic and spleenic expression of thyroid peroxidase and predisposition to autoimmune thyroiditis in mouse model, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.. 2004.

Ng H.P., Banga J.P. and Kung A.W.C., Promiscuous thymic and spleenic expression of thyroid peroxidase and predisposition to autoimmune thyroiditis in mouse model, American thyroid Association 75th Annual Meeting, 16-21 September 2003, Palm Beach, USA. Thyroid . 2003, 13(7): 703.

Researcher : Kuok UI

List of Research Outputs

Tang S.C.W., Cheng I.K.P., Leung V.K.S., Kuok U.I., Tang A.W.C., Ho Y.W., Lai K.N. and Chan D.T.M., Successful treatment of hepatitis C after kidney transplantation with combined interferon alpha-2b and ribavirin, Journal of Hepatology. 2003, 39: 875-878.

Researcher : Kwong YL

Project Title:	Provision of purine analogues for the treatment of patients with chronic lymphoid malignancies
Investigator(s):	Prof. Kwong Y.L., Prof. Liang R.H.S.
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation Grant
Start Date:	07/1997

Abstract:

To provide purine analogues for the treatment of patients with chronic lymphoid malignancies who cannot otherwise afford the drugs.

Project Title:	Molecular mechanisms and consequences of downregulation of p73 in natural killer cell lymphoma
Investigator(s):	Prof. Kwong Y.L., Ms Siu L.L.P.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2002

Abstract:

To define if p73 acts as a tumor suppressor gene in natural killer (NK) cell lymphomas; to define the biologic significance of re-expression of p73 in NK lumphoma cells that have p73 inactivated due to aberrant promoter methylation; to define the potential significance of p21 inactivation in NK lymphoma cells.

Project Title:	Molecular basis of arsenic resistance in tumours
Investigator(s):	Prof. Kwong Y.L., Dr. Tse E.W.C.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2003

Abstract:

To define the molecular basis of arsenic resistance in tumour cells.

List of Research Outputs

Au W.Y., Lie A.K.W., Liang R.H.S., Kwong Y.L., Yau C.C., Cheung M.M.C., Ngan K.C., Lau W.H., Wong K.H., Yiu H.Y., Cheng H.C., Au K.H. and Chang J.K.C., Autologous stem cell transplantation for nasal NK/T-cell lymphoma: a progress report on its value, Annals of Oncology. 2003, 14: 1673-1676.

Au W.Y., Ooi C.G.C., Yau W.F., Ma E.S.K., Wan T.S.K. and Kwong Y.L., Chronic myeloid leukemia in an adolescent with Ollier’s diease after intensive X ray exposure, Leukemia and Lymphoma. 2004, 45: 613-616.

Au W.Y., Fung A., Chim J.C.S., Lie A.K.W., Liang R.H.S., Ma E.S.K., Chan C.H., Wong K.F. and Kwong Y.L., FLT-3 aberrations in acute promyelocytic leukaemia: clinicopathological associations and prognostic impact, British Journal of Haematology. 2004, 125(4): 463-469.

Au W.Y., Lie A.K.W., Ma E.S.K., Lau G., Chan C. and Kwong Y.L., Late onset pure red cell aplasia due to delayed lymphoid engraftment complicating ABO mismatched hematopoietic stem cell transplantaion, Transfusion. 2004, 44: 946-947.

Au W.Y., Fung T.K., Ma E.S.K., Liang R.H.S. and Kwong Y.L., Low frequency of FLT3 gene internal tandem duplication and activating loop mutation in therapy-related acute myelocyticleukemia and myelodysplastic syndrome, Cancer Genetics and Cytogenetics. 2004, 149(2): 169-172.

Au W.Y., Cheng V.C.C., Ho P.L., Yuen K.Y., Hung I., Ma S.Y., Lie A.K.W., Liang R.H.S. and Kwong Y.L., Non tuberculous mycobacterial infections in Chinese hematopoietic stem cell transplantation recipients., Bone Marrow Transplantation. 2003, 32: 709-714.

Au W.Y., Kumana C.R., Kou M., Mak R., Chan G.C.F., Lam C.W. and Kwong Y.L., Oral arsenic trioxide in the treatment of relapsed acute promyelocytic leukemia, Blood. Washington, American Society of Hematology, 2003, 102(1): 407-408.

Au W.Y., Ma E.S.K., Wan T.S.K., Man C.W.Y. and Kwong Y.L., Pentasomy 8q after cyclophosphamide therapy for fibrosing alveolitis: case report and review, Cancer Genetics and Cytogenetics. 2003, 141: 79-82.

Au W.Y., Pang A.W.K., Choy C.K.W., Chim J.C.S. and Kwong Y.L., Quantification of circulating Epstein-Barr virus (EBV) DNA in the diagnosis and monitoring of natural killer cell and EBV-positive lymphomas in immunocompetent patients, Blood. 2004, 104(1): 243-9.

Au W.Y., Wong R.W.M., Wong B.C.Y., Lie A.K.W., Liang R.H.S., Leung A.Y.H. and Kwong Y.L., Reduced incidence of acute graft versus host disease of the gut in Chinese carriers of Helicobacter pylori during allogeneic bone marrow transplantation, Annals of Hematology. 2004, 83: 34-37.

Au W.Y., Lam C.C.K. and Kwong Y.L., Successful treatment of acquired factor VIII inhibitor with cyclosporine, Haemophilia. 2004, 10: 98-100.

Au W.Y., Lam C.C.K., Lie A.K.W., Pang A.W.K. and Kwong Y.L., T-cell large granular lymphocyte leukemia of donor origin after allogeneic bone marrow transplantation, Americal Journal of Clinical Pathology. 2003, 120: 626-30.

Au W.Y., Lie A.K.W., Siu L.L.P., Chan C., Ooi C.G.C., Leung A.Y.H., Liang R.H.S. and Kwong Y.L., Treatment of lymphoma relapses after allogeneic hematopoietic stem cell transplantation with intensive chemotherapy followed by infusion of hematopoietic stem cell from the original donor, Annals of Hematology. 2003, 82(9): 548-551.

Au W.Y., Lie A.K.W., Chan C., Pang A.W.K., Liang R.H.S., Ma E.S.K., Choy C.K.W. and Kwong Y.L., Treatment of post-renal transplantation lymphoproliferative disease manifesting as plasmacytoma with non-myeloablative hematopoietic stem cell transplantation from the same kidney donor, American Journal of Hematology. 2003, 74: 283-6.

Au W.Y., Cheung W.C., Lam C.C.K. and Kwong Y.L., Two factor XI gene mutations in a Chinese family with factor XI deficiency, American Journal of Hematology. 2003, 74: 136-8.

Au W.Y., Lam C.C.K., Lam C.C.K., Lam C.C.K., Cheung W.C. and Kwong Y.L., Two novel factor X deficiency mutations in a Chinese family, Annals of Hematology. 2004, 83: 304-306.

Chan A.C.L., Chan J.K.C., Yan K.W. and Kwong Y.L., Anaplastic large cell lymphoma presenting as a pleural effusion and mimicking primary effusion lymphoma. A report of 2 cases, Acta Cytologica . 2003, 47(5): 809-816.

Chan O.O., Peng J., Lam S.K., Hui W.M., Wong R.W.M., Yuen M.F., Kwong Y.L., Rashid A. and Wong B.C.Y., Reveral of E-Cadherin Promoter Hypermethylation Status after Helicobacter pylori Eradication, Gastroenterology. 2004, 126 (4 Suppl 2): 333.

Chen Y.W., Liang A.C.T., Au W.Y., Chu K.M., Wong K.Y., Hu X., Lu L., Tang J.C.O., Chan K.W., Beh S.L., Kwong Y.L., Liang R.H.S. and Srivastava G., Multiple BCL6 translocation partners in individual cases of gastric lymphoma, Blood. 2003, 102: 1931-1932.

Cheung T.Y.G., Yuen W.H., Kwong Y.L., Au W.Y., Man R.Y.K., Wong W.I. and Kumana C.R., Monitoring blood arsenic in outpatients with acute promyelocytic leukemia receiving oral arsenic trioxide, The 9th Southeast Asian-Western Pacific Regional Meeting of Pharmacologists. 2003, 7, Suppl. 1: 99.

Chim J.C.S., Wong A.S.Y. and Kwong Y.L., Aberrant methylation in acute promyelocytic leukemia: profile and prognostic significance, British Journal of Haematology. 2003, 122: 571-578.

Chim J.C.S., Wong A.S.Y. and Kwong Y.L., Absence of p300 gene promoter methylation in acute leukemia, Cancer Genetics and Cytogenetics. 2004, 150: 164-7.

Chim J.C.S., Wong A.S.Y. and Kwong Y.L., Epigenetic dysregulation of the Jak/STAT pathway by frequent aberrant methylation of SHP1 but not SOCS1 in acute leukaemias, Annals of Hematology. 2004, 83(8): 527-32.

Chim J.C.S., Wong A.S.Y. and Kwong Y.L., Epigenetic inactivation of INK4/CDK/RB cell cycle pathway in acute leukemias, Annals of Hematology . 2003, 82(12): 738-42.

Chim J.C.S., Kwong Y.L., Fung T.K. and Liang R.H.S., Methylation profiling in multiple myeloma, Leukemia Research. 2004, 28: 379-385.

Chim J.C.S., Ma A.Y., Au W.Y., Choy C.K.W., Lie A.K.W., Liang R.H.S., Yau C.C. and Kwong Y.L., Primary nasal natural killer cell lymphoma : long term treatment outcome and relationship with the international prognostic index., Blood. 2004, 103: 216-221.

Chim J.C.S., Fung T.K., Cheung W.C., Liang R.H.S. and Kwong Y.L., SOCS1 and SHP1 Hypermethylation in Multiple Myeloma: Implications for Epigenetic Activation of the Jak/STAT pathway, Blood. 2004, 103: 4630-4635.

Chu W.K., Cheung W.M.W. and Kwong Y.L., Differential effects of 9-cis, 13-cis and all-trans retinoic acids on the neuronal differentiation of human neuroblastoma cells, Neuroreport. 2003, 14(15): 1935-1939.

Jin Y., Jin C., Law S.Y.K., Chu K.M., Zhang H., Stromback B., Yuen P.W. and Kwong Y.L., Cytogenetic and fluorescence in situ hybridization characterization of clonal chromosomal aberrations and CCND1 amplification in esophageal carcinomas, Cancer Genetics Cytogenetics. 2004, 148(1): 21-28.

Jin Y., Zhang H., Tsao G.S.W., Jin C., Lv M., Strombeck B., Wiegant J., Wan T.S.K., Yuen P.W. and Kwong Y.L., Cytogenetic and molecular genetic characterization of immortalized human ovarian surface epithelial cell lines: consistent loss of chromosome 13 and amplification of chromosome 20, Gynecologic Oncology. 2004, 92: 183-191.

Kumana C.R., Au W.Y., Lee N.S., Kou M., Mak R.W.M., Lam C.W. and Kwong Y.L., Bioavailability of arsenic trioxide solubalised for oral administration to patients with haemic malignancies (P-11), In: FC Tuluney, M Orme, Sixth Congress of European Association of Clinical Pharmacology adn Therapeutics - European Collaboration: Towards Drug Development and Rational Drug Therapy. 2003, 73.

Kwong Y.L., Transient leukaemia in infants with trisomy 21, British Journal of Haematology. 2003, 122: 686-687.

Ma E.S.K., Au W.Y., Lie A.K.W., Ng I.O.L., Leung A.Y.H., Tse E.W.C., Liang R.H.S., Lau G. and Kwong Y.L., Liver graft-versus-host disease after donor lymphocyte infusion for relapses of hematologic malignancies post allogeneic hematopoietic stem cell transplantation, Bone Marrow Transplantation. 2004, 34: 57-61.

Ma S.Y., Au W.Y., Chim J.C.S., Lie A.K.W., Lam C.C.K., Tse E.W.C., Leung A.Y.H., Liang R.H.S. and Kwong Y.L., Fludarabine, mitoxantrone and dexamethasone in the treatment of indolent B-and T-cell lymphoid malignancies Chinese patients, British Journal of Haematology. 2004, 124: 754-761.

Ma S.Y., Au W.Y., Ng I.O.L., Lie A.K.W., Liang R.H.S., Lau G. and Kwong Y.L., Hepatitic graft-versus-host disease after hematopoietic stem cell transplantation : clinicopathologic features and prognostic implication, Transplantation. 2004, 77: 1252-1259.

Ma S.Y., Lie A.K.W., Au W.Y., Chim J.C.S., Kwong Y.L. and Liang R.H.S., Non-myeloablative allogeneic peripheral stem cell transplantation for multiple myeloma, Hong Kong Medical Journal. 2004, 10: 77-83.

Ma S.Y., Au W.Y., Ng I.O.L., Lie A.K., Leung A.Y., Liang R.H.S., Lau G. and Kwong Y.L., Role of liver biopsy in the management of liver dysfunction after hematopoietic stem-cell transplantation in a hepatitis B virus-prevalent patient population, Transplantation. 2003, 7691): 169-176.

Pang A., Ng I.O.L., Fan S.T. and Kwong Y.L., Clinicopathologic significance of genetic alterations in hepatocellular carcinoma, Cancer Genetics and Cytogenetics. 2003, 146(1): 8-15.

Pang A.W.K., Yuen M.F., Yuan H., Lai C.L. and Kwong Y.L., Real-time quantification of hepatitis B virus core-promoter and pre-core mutants during hepatitis E antigen seroconversion, Journal of Hepatology. 2004, 40: 1008-1017.

Pang R., Yuen J., Yuen M.F., Lai C.L., Lee K.W., Man K., Poon R.T.P., Fan S.T., Wong C.M., Ng I.O.L., Kwong Y.L. and Tse E., PIN1 over-expression and b-catenin gene mutations are distinct oncologic events in human hepatocarcinogenesis (Oral Presentation), The 8th Research Postgraduate Symposium, The University of Hong Kong, Hong Kong, 13 December 2003.

Pang R.W.C., Yuen J.C.H., Yuen M.F., Lai C.L., Lee K.W., Man K., Poon R.T.P., Fan S.T., Wong C.M., Ng I.O.L., Kwong Y.L. and Tse E.W.C., PIN1 over-expression and β-catenin gene mutations are distinct oncogenic events in human hepatocellular carcinoma, Oncogene. 2004, 23(23): 4182-6.

Shen L., Liang A.C.T., Lu L., Au W.Y., Wong K.Y., Tin P.C., Chan K.W., Ko K.H., Chen W.Y.W., Beh S.L., Shimizu N., Tsuchiyama T., Tang J.C.O., Kwong Y.L., Liang R.H.S. and Srivastava G., Aberrant BCL10 nuclear expression in nasal NK/T-cell lymphoma, Blood. 2003, 102(4): 1553-1554.

Shen L., Liang A.C.T., Au W.Y., Lu L., Chen W.Y.W., Wong K.Y., Tang J.C.O., Chan K.W., Beh S.L., Kwong Y.L., Liang R.H.S. and Srivastava G., BCL10 mutations are irrelevant to its aberrant nuclear localization in nasal NK/T-cell lymphoma, Leukemia. 2003, 17(11): 2240-2242.

Tse H.F., Thambar S., Kwong Y.L., Chen W.H., Lau C.P., Chan J.K.F., Lo G., Lai C.L. and Bellan G., Long-Term clinical outcome of catheter-based intramyocardial autologous bone marrow cells implanation in patients with end-stage coronary artery disease, J Am Coll Cardiol. 2004, 43: 39A.

Tse H.F., Kwong Y.L., Chan J.K.F., Lo R., Ho C.L., Yeung D.W. and Lau C.P., Therapeutic angiogenesis of human ischemic myocardium by catheter-based intramyocardial autologous bone marrow cell implantation, Lancet. 2003, 361: 47-9.

Wong T.S., Kwong D.L.W., Sham J.S.T., Wei W.I., Kwong Y.L. and Yuen P.W., Clinicopathologic significance of plasma matrix metalloproteinase-2 and -9 levels in patients with undifferentiated nasopharyngeal carcinoma, European Journal of Surgical Oncology. 2004, 30(5): 560-564.

Wong T.S., Kwong D.L.W., Sham J.S.T., Tsao G.S.W., Wei W.I., Kwong Y.L. and Yuen P.W., Promoter Hypermethylation Of High-in-normal 1 Gene In Primary Nasopharyngeal Carcinoma, Clinical Cancer Research. 2003, 9: 3042-3046.

Wong T.S., Kwong D.L.W., Sham J.S.T., Wei W.I., Kwong Y.L. and Yuen P.W., Quantitative plasma hypermethylated DNA markers of undifferentiated nasopharyngeal carcinoma, Clinical Cancer Research. 2004, 10(7): 2401-2406.

Wong T.S., Man M., Lam A.K.Y., Wei W.I., Kwong Y.L. and Yuen P.W., The study of p16 and p15 gene methylation in head and neck squamous cell carcinoma and their quantitative evaluation in plasma by real-time PCR, European Journal of Cancer. 2003, 39(13): 1881-1887.

Zhang H., Tsao G.S.W., Jin C., Stromback B., Yuen P.W., Kwong Y.L. and Jin Y., Sequential Cytogenetic and Molecular Cytogenetic Characterization of an SV40T Immortalized Nasopharyngeal Cell Line transformed by Epstein-Barr virus latent membrane protein-1 gene, Cancer Genetics and Cytogenetics . 2004, 150: 144-52.

Researcher : Lai CL

List of Research Outputs

Chan O.O., Ng I.O.L., Lam C.M., Shek T.W.H. and Lai C.L., Cholestatic jaundice caused by sequential carbimazole and propylthiouracil treatment for thyrotoxicosis, Hong Kong Medical Journal. 2003, 9(5): 377-380.

Chan O.O., Yuen M.F., Lam C.M., Fong C.Y., Wong B.C.Y. and Lai C.L., Prevalence and Characteristics of Familial Hepatocellular Carcinoma Caused by Chronic Hepatitis B Infection in Hong Kong, Alimentary Pharmacology and Therapeutics. 2004, 19(4): 401-6.

Chau T.N., Lee K.C., Yao H., Tsang T.Y., Chow T.C., Yeung Y.C., Choi K.W., Tso Y.K., Lau T., Lai T.S.T. and Lai C.L., SARS-associated Viral Hepatitis Caused By A Novel Coronavirus: Report Of Three Cases, Hepatology. 2004, 39: 302-310.

Ho J.C.M., Wong R.W.M., Ooi C.G.C., Mok T.Y., Hung I.F., Ng W., Lam Y.M., Tam W.O., Wong P.C., Ho P.L., Lai C.L., Lam W.K., Lam S.K. and Tsang K.W.T., Correlation of Liver Dysfunction And Disease Activity In Patients With Severe Acute Respiratory Syndrome, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-08.

Hui C.K., Lai K.C., Yuen M.F., Ng M.M.T., Chan C.K., Hu H.C., Wong R.W.M., Lai C.L. and Wong B.C.Y., Does the Addition of Endoscopic Sphincterotomy to Stent Insertion Improve Drainage of the Bile Duct in Acute Suppurative Cholangitis?, Gastrointestinal Endoscopy. 2003, 58(4): 500-4.

Hui C.K., Yuen M.F., Wong W.M., Lam S.K. and Lai C.L., Mirtazapine Induced Hepatotoxicity, Journal of Clinical Gastroenterology. 2003, 35(3): 270-271.

Hui C.K., Lai K.C., Yuen M.F., Wong R.W.M., Chan O.O., Ng M.M.T., Chan C.K., Cheung W.W., Lam S.K., Lai C.L. and Wong B.C.Y., The Role of Cholecystectomy in Reducing Recurrent Gallstone Pancreatitis, Endoscopy. 2004, 36(3): 206-11.

Lai C.L., Chairman, BMS Symposium at Hong Kong-Shanghai International Liver Congress 2004. 2004.

Lai C.L., Co-chaired an Oral Session , 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004.

Lai C.L., Guest speaker on "Overview of New Antiviral Agents for Chronic Hepatitis B, First International Liver Symposium for Evolving Issue in Asia-Pacific Countries on "Antiviral Therapy for Hepatitis B; Past, Present and Future" held in Seoul, Korea. 2004.

Lai C.L., Invited lecture on "Clinical challenge 4: Managing Expectations from Therapy: What Is The Duration of Response And When Should Therapy Be Stopped?", CME-accredited Symposium "Unanswered Questions in the Treatment of Chronic Hepatitis B" jointly organized by CME Consultants, Inc. and Bristol-Myers Squibb Company in Boston, Massachusetts, USA.. 2003.

Lai C.L., Invited lecture on "Current Antiviral Therapy For Hepatitis B: The Perspective From Asia", CME Satellite Symposium "Optmizing the Management of Hepatitis B 2003" sponsored by Ochsner Clinic Foundation, L.L.C. and jointly supported by Idenix Pharmaceuticals Inc and Novartis Pharmaceucials Corporation in Boston, Massachusetts, USA. 2003.

Lai C.L., Invited lecture on "Treatment of Chronic Hepatitis B", Hong Kong College of Family Physicians. 2003.

Lai C.L., Invited lecture on "Update on Non A Hepatitis", CME Luncheon Meeting of The Private Practising Paediatricians Study Group. 2003.

Lai C.L., Invited lecture on "Use of Nucleoside Analogues in Chronic Hepatitis B Virus Infection", Hong Kong-Shanghai International Liver Congress 2004, Hong Kong. 2004.

Lai C.L., Invited speaker on "New Insights in antiviral Treatment of Chronic Hepatitis B" at the "Advances in Medicine 2004", Faculty of Medicine, The Chinese University of Hong Kong in Hong Kong Convention and Exhibition Centre. 2004.

Lai C.L., Invtied moderator for the Poster Discussion on "Viral Hepatitis", Biennial Scientific Meeting of the International Association for the Study of the Liver in Salvador, Bahia. 2004.

Lai C.L., Lecture on "Entecavir is Superior to Lamivudine in Reducing Hepatitis B Virus DNA in Patients with Chronic Hepatitis B Infection", Hong Kong-Shanghai International Liver Congress 2004, Hong Kong. 2004.

Lai C.L., Lecture on "What Should be the Endpoint of Chronic Hepatitis B Treatment", Plenary Session II, the 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004.

Lai C.L., Lecture on the "Treatment of HBV infection", Seminar on Viral Hepatitis for Nurses 2004 in the Lecture Theatre of Hong Kong Central Library. 2004.

Lai C.L., Member of the Editorial Board, European Review for Medical and Pharmacological Sciences. 2004.

Lai C.L., Member of the International Advisory Board, 20th Edition of Davidson's Principles and Practice of Medicine. 2004.

Lai C.L., President, Medical Society, Hong Kong University Students' Union. 2003.

Lai C.L., Leung N.W.Y., Teo E.K., Tong M., Wong F., Hann H.W., Han S., Poynard T., Myers M., Chao G., Lloyd D. and Brown N., Results of a One-year International Phase IIB Comparative Trial of Telbivudine, Lamivudine, and the Combination, in Patients with Chronic Hepatitis B, Hepatology. 2003, 38, No. 4, Suppl. 1: 262A.

Lai C.L., Reviewer, Digestive and Liver Disease formerly The Italian Journal of Gastroenterology and Hepatology. 2004.

Lai C.L., Reviewer, Liver International. 2003.

Lai C.L., Talk on "Chronic Hepatitis B – Durability of Response to Therapy and Therapeutic End-points", International Symposium on Hepatology 2003 organised by The Hong Kong Association for the Study of Liver Diseases. 2003.

Lai C.L., Talk on "Do Nucleoside/Nucleotide Analogues Meet the Management Challenge?", GSK Symposium at the Hong Kong-Shanghai International Liver Congress 2004, Hong Kong. 2004.

Lai C.L., Talk on "L-thymidine and Related Compounds", Next Generation of HBV Inhibitors Session of the "HEP DART 2003: Frontiers in Drug Development for Viral Hepatitis" in Hawaii, USA. 2003.

Lai C.L., Talk on "Newer Developments of the Hepatitis B Virus - Precore Mutations and HBV Genotype", Colloquium of Bristol-Myers Squibb Company in New York, USA. 2003.

Lai C.L., Talk on "Treatment of Chronic Hepatitis B", Hong Kong College of Family Physicians. 2003.

Lai C.L., Therapeutic Advances in Chronic Hepatitis B , Journal of Gastroenterology and Hepatology. 2004, 19 Suppl: S5-9.

Lai C.L., Ratziu V., Yuen M.F. and Poynard T., Viral Hepatitis B, Lancet. 2003, 362: 2089-2094.

Liu C.L., Fan S.T., Lo C.M., Chan S.C., Ng I.O.L., Lai C.L. and Wong J., Interleukin-2 receptor antibody (basiliximab) for immunosuppressive induction therapy after liver transplantation: a protocol with early elimination of steroids and reduction of tacrolimus dosage, Liver Transplantation. 2004, 10(6): 728-733.

Liu C.L., Fan S.T., Lo C.M., Wei W.I., Yong B.H., Lai C.L. and Wong J., Live-donor liver transplantation for acute-on-chronic hepatitis B liver failure, Transplantation. 2003, 76: 1174-1179.

Lo C.M., Cheung S.T., Ng I.O.L., Liu C.L., Lai C.L. and Fan S.T., Fibrosing cholestatic hepatitis secondary to precore/core promoter hepatitis B variant with lamivudine resistance: successful retransplantation with combination adefovir dipivoxil and hepatitis B immunoglobulin, Liver Transplantation. 2004, 10(4): 557-563.

Lok A.S., Lai C.L., Leung N., Yao G.B., Cui Z.Y., Schiff E.R., Dienstag J.L., Heathcote J., Little N.R., Griffiths D.A., Gardner S.D. and Castiglia M., 5-year Follow-up of 998 Chronic Hepatitis B Patients to Determine Long-term Safety of Lamivudine and clinical Consequences of Lamivudine-Resistant Mutations, Hepatology. 2003, 38, No. 4, Suppl. 1: 708A.

Lok A.S.F., Lai C.L., Leung N., Yao G.B., Cui Z.Y., Schiff E.R., Dienstag J.L., Heathcote E.J., Little N.R., Griffiths D.A., Gardner S.D. and Castiglia M., Long-term Safety Of Lamivudine Treatment In Patients With Chronic Hepatitis B, Gastroenterology. 2003, 125: 1714-1722.

Pang A.W.K., Yuen M.F., Yuan H., Lai C.L. and Kwong Y.L., Real-time quantification of hepatitis B virus core-promoter and pre-core mutants during hepatitis E antigen seroconversion, Journal of Hepatology. 2004, 40: 1008-1017.

Pang R., Yuen J., Yuen M.F., Lai C.L., Lee K.W., Man K., Poon R.T.P., Fan S.T., Wong C.M., Ng I.O.L., Kwong Y.L. and Tse E., PIN1 over-expression and b-catenin gene mutations are distinct oncologic events in human hepatocarcinogenesis (Oral Presentation), The 8th Research Postgraduate Symposium, The University of Hong Kong, Hong Kong, 13 December 2003.

Pang R.W.C., Yuen J.C.H., Yuen M.F., Lai C.L., Lee K.W., Man K., Poon R.T.P., Fan S.T., Wong C.M., Ng I.O.L., Kwong Y.L. and Tse E.W.C., PIN1 over-expression and β-catenin gene mutations are distinct oncogenic events in human hepatocellular carcinoma, Oncogene. 2004, 23(23): 4182-6.

Poynard T., Yuen M.F., Ratziu V. and Lai C.L., Viral Hepatitis C, Lancet. 2003, 362: 2095-2100.

Schiff E., Lai C.L., Hadziyannis S., Neuhaus P., Terrault N., Lampertico P., Tillmann H., Didier S., Lama N., James C., Currie G. and Brosgart C.L., Adefovir Dipivoxil 10mg (ADV) for the Treatment of Chronic Hepatitis B in Patients Pre-liver Transplantation with Lamivudine-resistant Patients, Hepatology. 2003, 38, No. 4, Supp 1: 161A.

Schiff E.R., Lai C.L., Hadziyannis S., Neuhaus P., Terrault N., Colombo M., Tillmann H.L., Samuel D., Zeuzem S., Lilly L., Rendina M., Villeneuve J.P., Lama N., James C., Wulfsohn M.S., Namini H., Westland C., Xiong S., Choy G.S., Van Doren S., Fry J. and Brogart C.L., Adefovir Dipivoxil Therapy For Lamivudine-Resistant Hepatitis B In Pre- And Post-Liver Transplantation Patients, Hepatology. 2003, 38: 1419-1427.

Wong W.M., Ho J.C.M., Hung I.F., Ng W., Lam Y.M., Tam W.O., Wong B.C.Y., Wong P.C., Lai C.L., Lam W.K., Lam S.K., Tsang K.W.T., Ooi C.G.C., Ho P.L., Mok T. and Chan J., Temporal Patterns of Hepatic Dysfunction and Disease Severity in Patients with SARS, Journal of the American Medical Association Southeast Asia (JAMA). 2003, 290(20): 2663-2665.

Yuan H., Yuen M.F., Wong D.K.H., Sum S.M., Doutreloigne J., Sablon E. and Lai C.L., Determinants for the Occurrence of Acute Exacerbation after HBeAg Seroclearance in Chinese Patients, Hepatology. 2003, 38, No. 4, Suppl. 1: 623A.

Yuen M.F., Kato T., Mizokami M., Chan O.O., Yuen J.C.H., Yuan H., Wong D.K.H., Sum S.M., Ng I.O.L., Fan S.T. and Lai C.L., Clinical outcome and virologic profiles of severe hepatitis B exacerbation due to YMDD mutations, Journal of Hepatology. 2003, 39(5): 850-855.

Yuen M.F., Wong D.K.H., Sablon E., Tse E.W.C., Ng I.O.L., Yuan H., Siu C.W., Sander T.J., Bourne E.J., Hall J.G., Condreay L.D. and Lai C.L., HBsAg seroclearance in chronic hepatitis B in the Chinese: Virological, histological, and clinical aspects, Hepatology. 2004, 39(6): 1694-1701.

Yuen M.F., Tanaka Y. and Lai C.L., Hepatitis B Genotypes in Chronic Hepatitis B And Lamivudine Therapy, Intervirology. 2003, 46: 373-376.

Yuen M.F., Wong D.K.H., Sablon E., Yuan H., Sum S.M., Hui C.K., Chan O.O., Wong B.C.Y. and Lai C.L., Hepatitis B Virus Genotypes B and C Do Not Affect The Antiviral Response To Lamivudine, Antiviral Therapy. 2003, 8: 531-534.

Yuen M.F., Wong D.K.H., Sablon E., Yuan H., Sum S.M., Hui C.K., Wong B.C.Y. and Lai C.L., Hepatitis B Virus Genotypes B and C Do Not Affect the Anti-viral Response to Lamivudine, Hepatology. 2003, 38, No. 4, Suppl. 1: 723A.

Yuen M.F., Sablon E., Wong K.H.D., Yuan H., Wong B.C.Y., Chan O.O. and Lai C.L., Role of Hepatitis B Virus Genotypes in Chronic Hepatitis B Exacerbation, Clinical Infectious Diseases. 2003, 37: 593-7.

Yuen M.F. and Lai C.L., Screening For Hepatocellular Carcinoma: Survival Benefit And Cost-effectiveness, Annals of Oncology. 2003, 14: 1463-1467.

Yuen M.F. and Lai C.L., Specific Considerations In The Design Of Hepatitis B Virus Clinical Studies In The Far East, In: Humana Press, Totowa, New Jersey, USA, Ed. Hamatake RK, Lau JYN., Hepatitis B and D Protocols. Volume II: Immunology, Model Systems and Clinical Studies. Humana Press Inc., 2004, II: 457-464.

Researcher : Lai KC

List of Research Outputs

Hui C.K., Lai K.C., Yuen M.F., Ng M.M.T., Chan C.K., Hu H.C., Wong R.W.M., Lai C.L. and Wong B.C.Y., Does the Addition of Endoscopic Sphincterotomy to Stent Insertion Improve Drainage of the Bile Duct in Acute Suppurative Cholangitis?, Gastrointestinal Endoscopy. 2003, 58(4): 500-4.

Hui C.K., Liu C.L., Lai K.C., Chan S.C., Hu H.C., Wong R.W.M., Cheung W.W., Ng M.M.T., Yuen M.F., Chan O.O., Lo C.M., Fan S.T. and Wong B.C.Y., Outcome of emergency ERCP for acute cholangitis in patients 90 years of age and older, Alimentary Pharmacology and Therapeutics. 2004, 19(11): 1153-1158.

Hui C.K., Lai K.C., Yuen M.F., Wong R.W.M., Chan O.O., Ng M.M.T., Chan C.K., Cheung W.W., Lam S.K., Lai C.L. and Wong B.C.Y., The Role of Cholecystectomy in Reducing Recurrent Gallstone Pancreatitis, Endoscopy. 2004, 36(3): 206-11.

Lai K.C., Lam S.K., Chu K.M., Hui W.M., Kwok K.F., Wong B.C.Y., Hu H.C., Wong R.W.M., Chan O.O. and Chan C.K., Lansoprazole Reduces Ulcer Relapse after Eradication of Helicobacter pylori in Nonsteroidal Anti-Inflammatory Drug Users--a Randomized Trial, Alimentary Pharmacology and Therapeutics. 2003, 18(8): 829-36.

Wong B.C.Y., Wong R.W.M., Cheung K.L., Tong S.M., Rozen P., Young G.P., Chu K.W., Ho J.W.C., Law W.L., Tung H.M., Lai K.C., Hu H.C., Chan C.K. and Lam S.K., A Sensitive Guaiac Fecal Occult Blood Test is Less Useful than an Immunochemical Test for Colorectal Cancer Screening in a Chinese Population , Alimentary Pharmacology and Therapeutics. 2003, 18(9): 941-946.

Wong B.C.Y., Lam S.K., Wong R.W.M., Chen J.S., Zheng T., Feng R., Lai K.C., Hu H.C., Yuen S.T., Leung S.Y., Fong D.Y.T., Ho J.C.Y., Ching C.K. and Chen J.S., Helicobacter pylori Eradication to Prevent Gastric Cancer in a High-Risk Region of China: a Randomized Controlled Trial, The Journal of American Medical Association. 2004, 291(2): 187-194.

Wong B.C.Y., Lam S.K., Wong R.W.M., Chen J.S., Zheng T., Feng R., Lai K.C., Hu H.C., Yuen S.T., Leung S.Y., Fong D.Y.T., Ho J.W.C. and Ching C.K., Helicobacter pylori eradication to prevent gastric cancer in a high-risk region in China: A randomized controlled trial, JAMA. 2004, 291(2): 187-194.

Wong R.W.M., Lai K.C., Hui W.M., Lam K.F., Huang J., Hu H.C., Wong Y.H., Lam C.L.K., Xia H.H.X., Chan O.O., Lam S.K. and Wong B.C.Y., Double-blind, Randomized Controlled Study to Assess the Effects of Lansoprazole 30 mg and Lansoprazole 15 mg on 24-h Oesophageal and Intragastric pH in Chinese Subjects with Gastro-Oesophageal Reflux Disease, Alimentary Pharmacology and Therapeutics. 2004, 19(4): 455-62.

Wong R.W.M., Lai K.C., Hui W.M., Hu H.C., Huang J., Wong Y.H., Xia H.H.X., Chan O.O., Lam S.K. and Wong B.C.Y., Pathophysiology of Gastro-oesophageal Reflux Diseases in Chinese – Role of Transient Lower Oesophageal Sphincter Relaxation and Oesophageal Motor Dysfunction, Gastroenterology. 2004, 126 (4 Suppl 2): T1724.

Wong R.W.M., Lam K.F., Cheng C., Hui W.M., Xia H.H.X., Lai K.C., Hu H.C., Huang J., Lam C.L.K., Chan C.K., Chan O.O., Lam S.K. and Wong B.C.Y., Population Based Study of Noncardiac Chest Pain in Southern Chinese: Prevalence, Psychosocial Factors and Health Care Utilization, World Journal of Gastroenterology. 2004, 10(5): 707-712.

Wong W.M., Gu Q., Wang W., Fung F.M.Y., Berg D.E., Lai K.C., Xia H.H.X., Hu H.C., Chan C.K., Chan O.O., Yuen M.F., Hui C.K., Lam S.K. and Wong B.C.Y., Effects of Primary Metronidazole and Clarithromycin Resistance to Helicobacter pylori on Omeprazole, Metronidazole, and Clarithromycin Triple-Therapy Regimen in a Region with High Rates of Metronidazole Resistance, Clinical Infectious Diseases. 2003, 37(7): 882-9.

Wong W.M., Lam S.K., Tong S.M., Cheung K.L., Tang V.S.Y., Xia H.H.X., Lai K.C., Hu H.C., Chan C.K., Yuen M.F., Chan O.O. and Wong B.C.Y., Evaluation of a Rapid Stool Antigen Test for the Diagnosis of Helicobacter pylori Infection in Chinese Patients, Chinese Journal of Digestive Diseases. 2003, 4: 132-135.

Wong W.M., Lai K.C., Lam K.F., Hui W.M., Hu H.C., Lam C.L.K., Xia H.H.X., Huang J., Chan C.K., Lam S.K. and Wong B.C.Y., Prevalence, Clinical Spectrum and Health Care Utilization of Gastro-Oesophageal Reflux Disease in a Chinese Population: a Population-Based Study, Alimentary Pharmacology and Therapeutics. 2003, 18(6): 595-604.

Researcher : Lai KN

Project Title:	Establishment of immortalized B-lymphocyte cell lines for subsequent development of monoclonal antibodies against SARS-associated Coronavirus with clinical application in early diagnosis and future treatment
Investigator(s):	Prof. Lai K.N., Prof. Kwong Y.L., Dr. Tsang K.W.T.
Department:	Medicine
Source(s) of Funding:	SARS Research Fund
Start Date:	07/2003

Abstract:

To explore the therapeutic value of these monoclonal antibodies as an adjuvant immuno-modulating therapy.

Project Title:	Development of monoclonal antibodies against SARS-associated coronavirus: specific targeting for early diagnosis and future treatment
Investigator(s):	Prof. Lai K.N., Dr. Chung S.S.M., Prof. Kwong Y.L., Prof. Tam J.S.L., Dr. Tsang K.W.T.
Department:	Medicine
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	08/2003

Abstract:

To produce immortal B lymphocyte clones from these subjects recovering from SARS; to develop specific hybridomas from these human immortalized B lymphocytes that produce antibodies against SARS-related coronavirus; to determine the specificities of different monoclonal antibodies from the hybridomas against different protein components of the virus; to determine the application of these monoclonal antibodies for rapid diagnosis by using serum and/or tissue collected from patients at different stages of their illness; to explore the therapeutic value of these monoclonal antibodies as an adjuvant immuno-modulating therapy.

Project Title:	Chemokine production and T cell interaction in chronic glomerulo-nephritides and interstitial nephritis: exploration of tubulo-glomerular communication
Investigator(s):	Prof. Lai K.N., Dr. Leung J.C.K., Dr. Tang S.C.W.
Department:	Medicine
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	10/2003

Abstract:

To study tubulo-glomerular crosstalk in the presence of proteinuria. Activated PTEC induce proliferation and matrix formation in mesangial cells via soluble factors (alone or with participation of infiltrating T cells/monocytes); to determine whether PTEC may undergo epithelial-mesenchymal transidfferentiation under the influence of glomerulopathic proteins (alone or with participation of infiltrating T cells/monocytes); to examine whether activated mesangial cells (HMC) induce tubular expression of proinflammatory mediators (complement, chemokine, and growth factor) and the subsequent development of tubular epithelial-mesenchymal transdifferentiation via soluble factors (alone or with participation of infiltrating T cells/monocytes).

Project Title:	Chemokine production and T cell interaction in chronic glomerulo-nephritides and interstitial nephritis: exploration of tubulo-glomerular communication
Investigator(s):	Prof. Lai K.N., Dr. Leung J.C.K., Dr. Tang S.C.W.
Department:	Medicine
Source(s) of Funding:	RGC Projects (Block Grant Funded)
Start Date:	10/2003

Abstract:

Project Title:	The role of the renin-angiotensin system in the tubulointerstitial injury of IgA nephropathy (IgAN)
Investigator(s):	Prof. Lai K.N., Dr. Leung J.C.K.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	02/2004

Abstract:

To define the role of RAS in inducing PTEC/MC damage and; to elucidate the cross-talk between resident cells and infiltrating cells (T-cells/monocytes).

List of Research Outputs

Chan L.Y., Leung J.C.K., Tsang W.L., Chan D.T.M., Tang S.C.W. and Lai K.N., Activation Of Human Proximal Renal Tubular Epithelial Cells By Mediators Released From Mesangial Cells Cultured With IgA, Journal of the American Society of Nephrology. 2003, 14: 375A.

Chan M.M.W., Seto W.H., Sung J.J., Lai T.S.T., Yee W., Yam L.Y.C., Tsang K.W.T., Ip M.S.M., Lam W.K. and Lai K.N., Severe Acute Respiratory Syndrome: Patients Were Epidemiologically Linked, British Medical Journal. 2003, 326: 1393.

Choy C.B.Y., Chan D.T.M., Lo R.S.K., Lo W.K. and Lai K.N., Renal transplantation in patients with primary immunoglobulin A nephropathy, Nephrology Dialysis Transplantation. 2003, 18: 2399-2404.

Guo H., Leung J.C.K., Chan L.Y., Chan D.T.M. and Lai K.N., The pathogenetic role of immunoglobulin G from patients with systemic lupus erythematosus in the development of lupus pleuritis, Rheumatology. 2004, 43: 286-293.

Ho J.C.M., Ooi C.G.C., Mok T.Y., Chan J.W., Hung I., Lam B., Wong P.C., Li P.C., Ho P.L., Lam W.K., Ng C.K., Ip M.S.M., Lai K.N., Chan M.M.W. and Tsang K.W.T., High-dose pulse versus nonpulse corticosteroid regimens in severe acute respiratory syndrome, American Journal of Respiratory and Critical Care Medicine. 2003, 168: 1449-1456.

Jones B.M., Ma E.S.K., Peiris J.S.M., Wong P.C., Ho J.C.M., Lam B., Lai K.N. and Tsang K.W.T., Prolonged disturbances of in vitro cytokine production in patients with severe acute respiratory syndrome (SARS) treated with ribavirin and steroids, Clinical & Experimental Immunology. 2004, 135: 467-473.

Lai K.N., Advisor, Royal Australasian College of Physicians. 2003.

Lai K.N., Advisor, Royal College of Physicians, London, United Kingdom. 2003.

Lai K.N., Board of Consultant, International Journal of Artifial Organs. 2003.

Lai K.N., Chair, Abstract Reviewing Panel, Peritoneal Dialysis Section, 36th Annual Scientific Meeting of the American Society of Nephrology, San Diego, USA. 2003.

Lai K.N., Tsang K.W.T., Seto W.H. and Ooi C.G.C., Clinical, Laboratory, and Radiologic Manifestation of SARS, Current Infectious Disease Reports. 2004, 6: 213-219.

Lai K.N., Editor, Nephrology. 2003.

Lai K.N., Editorial Board, Chinese Journal of Nephrology, Dialysis and Transplantation. 2003.

Lai K.N., Editorial Board, Kidney International. 2003.

Lai K.N., Interesting issues of systemic lupus erythematosus, 20th Anniversary Meeting of the Taiwan Society of Nephrology, Kaohsiung, Taiwan. 2003.

Lai K.N., Journal Advisory Board, Journal of Internal Medicine. 2003.

Lai K.N., Management of Hepatitis in End-stage Renal Diseases, American Journal of Nephrology. 2004, 24: 79.

Lai K.N., Management of hepatitis in end-stage renal failure, NephroAsia 2004, Singapore. 2004.

Lai K.N., Member of the Ethics Committee, Hong Kong Sanatorium & Hospital, Limited. 2003.

Lai K.N., Member of the Ethics Committee, Princess Margaret Hospital. 2003.

Lai K.N., New Therapeutic Approaches For Lupus Nephritis, American Journal of Nephrology. 2004, 24: 78-79.

Lai K.N., New therapeutic approach to lupus nephritis, NephroAsia 2004, Singapore. 2004.

Lai K.N., Lam M.F. and Leung J.C.K., Peritoneal function: the role of aquaporins, Peritoneal Dialysis International. 2003, 23 (Suppl 2): S20-S25.

Lai K.N., Tang S.C.W., Guh J.Y., Chuang T.D., Lam M.F., Chan L.Y., Tsang W.L. and Leung J.C.K., Polymeric IgA1 from patients with IgA nephropathy upregulates transforming growth factor-beta synthesis and signal transduction in human mesangial cells via the renin-angiotensin system, Journal of American Society of Nephrology. 2003, 14: 3127-3137.

Lai K.N., Visitor Professor, Kaohsiung Medical College, Taiwan. 2003.

Lam M.F., Lo W.K., Li C.S., Wong A., Cheung K.O., Tong K.L. and Lai K.N., A Multi-Center Prospective Study For Adequacy Of Dialysis Of Asian Patients In Long-Term Peritoneal Dialysis, Journal of the American Society of Nephrology. 2003, 14: 209A.

Lam M.F., Tang S.C.W. and Lai K.N., Dialysis-related amyloidosis revisited, International Journal of Artificial Organs. 2003, 26: 892-896.

Lam M.F., Lo W.K., Lui S.L., Li F.K., Chan D.T.M. and Lai K.N., Eosinophilic Peritonitis Has Deleterious Effect On Peritoneal Dialysis Patients Survival, Journal of the American Society of Nephrology. 2003, 14: 862A.

Leung J.C.K., Chan L.Y., Tsang W.L., Tang S.C.W. and Lai K.N., Anti-Macrophage Migration Inhibitory Factor Reduces Transforming Growth Factor-1b Expression In Experimental IgA Nephropathy, Journal of the American Society of Nephrology. 2003, 14: 408A.

Li F.K., Lai C.K., Poon W.T., Chan A.Y.W., Chan K.W., Tse K.C., Chan D.T.M. and Lai K.N., Aggravation of non-steroidal anti-inflammatory drug-induced hepatitis and acute renal failure by slimming drug containing anthraquinones, Nephrology Dialysis Transplantation. 2004, 19(7): 1916-1917.

Li F.K., Yip T., Tse K.C., Chan D.T.M. and Lai K.N., Artificial Stiffness And Central Aortic Blood Pressure As Determined By Pulse Wave Analysis In Chronic Dialysis And Post-Renal Transplant Patients, Journal of the American Society of Nephrology. 2003, 14: 535A.

Li F.K., Tse K.C., Lam M.F., Yip T.P.S., Lui S.L., Chan G.S.W., Chan K.W., Chan E.Y.T., Choy C.B.Y., Lo W.K., Chan D.T.M. and Lai K.N., Incidence and outcome of antiglomerular basement membrane disease in Chinese, Nephrology (Carlton). 2004, 9: 100-104.

Lui S.F., Li F.K., Choy C.B.Y., Chan D.T.M., Lo W.K. and Lai K.N., Long-term Outcome of Isoniazid Prophylaxis Against Tuberculosis in Chinese Renal Transplant Recipients. , Transplant Infectious Disease. 2004, 6: 55-56.

Lui S.L., Chan D.T.M., Lo W.K. and Lai K.N., Chronic inflammatory demyelinating polyneuropathy after initiation of peritoneal dialysis--a distinct clinical entity?, International Journal of Artificial Organs. 2003, 26: 969-971.

Mok C.C., Wong R.W.S. and Lai K.N., Treatment of severe proliferative lupus nephritis: the current state, Annals of the Rheumatic Diseases. 2003, 62: 799-804.

Ooi C.G.C., Khong P.L., Lam B., Ho J.C.M., Yiu W.C., Wong R.W.M., Wang T., Ho P.L., Wong P.C., Chan R.H., Lam W.K., Lai K.N. and Tsang K.W.T., Relationship between radiological and clinical parameters in SARS, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia, 2003. Abstract Book: OP2-01, p.73.

Ooi C.G.C., Khong P.L., Lam B., Ho J.C.M., Yiu W.C., Wong R.W.M., Wang T., Ho P.L., Chan R.H., Lam W.K., Lai K.N. and Tsang K.W.T., Severe acute respiratory syndrome : Relationship between radiological and clinical parameters, Radiology. 2003, 229: 492-499.

Ooi C.G.C., Khong P.L., Ho J.C.M., Lam B., Wong R.W.M., Yiu M.W.C., Wong P.C., Wong C.F., Lai K.N. and Tsang K.W.T., Severe acute respiratory syndrome: radiographic evaluation and clinical outcome measures, Radiology. 2003, 229: 500-506.

Tang S.C.W., Leung J.C.K., Tang A., Ho Y.W., Chan L.Y., Chan D.T.M. and Lai K.N., A Prospective, Randomized, Case-Controlled Study On The Efficacy Of Mycophenolate Mofetil For IgA Nephropathy Patients With Persistent Proteinuria Despite Angiotensin Blockade, Journal of the American Society of Nephrology. 2003, 14: 752A.

Tang S.C.W. and Lai K.N., Acute Hydrothorax In A Peritoneal Dialysis Patient: Long Term Efficacy Of Autologous Blood Cell Pleurodesis Associated With Small-Volume Peritoneal Exchange, Nephrology, Dialysis and Transplantation. 2003, 18: 2452.

Tang S.C.W. and Lai K.N., Acute Hydrothorax In Peritoneal Dialysis Patients: Diagnosis And Treatment Options, Nephrology, Dialysis and Transplantation. 2003, 18: 2452.

Tang S.C.W., Leung J.C.K., Chan L.Y., Tsang W.L., Chen X., Zhou W., Lai K.N. and Sacks S.H., Regulation of complement C3 and C4 synthesis in human peritoneal mesothelial cells by peritoneal dialysis fluid, Clinical & Experimental Immunology. 2004, 136: 85-94.

Tang S.C.W., Lui S.L., Lo C.Y., Lo W.K., Cheng I.K.P., Lai K.N. and Chan D.T.M., Spousal renal donor transplantation in Chinese subjects: a 10 year experience from a single centre, Nephrology Dialysis Transplantation. 2004, 19: 203-206.

Tang S.C.W., Cheng I.K.P., Leung V.K.S., Kuok U.I., Tang A.W.C., Ho Y.W., Lai K.N. and Chan D.T.M., Successful treatment of hepatitis C after kidney transplantation with combined interferon alpha-2b and ribavirin, Journal of Hepatology. 2003, 39: 875-878.

Tse K.C., Lam M.F., Yip P.S., Li F.K., Lai K.N. and Chan D.T.M., A long-term study on hyperlipidemia in stable renal transplant recipients, Clinical Transplantation. 2004, 18: 274-280.

Tse K.C., Chan D.T.M., Wong S.S.Y., Chan K.W., Lam M.F., Chan K.H.N., Li F.K., Chung B.C.Y. and Lai K.N., Granulomatous interstitial nephritis of the allograft kidney associated with rhodococcal pulmonary infection. Nephrol Dial Transplant, Nephrology Dialysis Transplantation. 2004, 19: 486-490.

Tse K.C., Lam M.F., Yip P.S., Li F.K., Choy C.B.Y., Lai K.N. and Chan D.T.M., Idiopathic Minimal Change Nephrotic Syndrome In Older Adults: Steroid Responsiveness And Pattern Of Relapses, Nephrology, Dialysis and Transplantation. 2003, 18: 1316-1320.

Tse K.C., Li F.K., Chan D.T.M. and Lai K.N., Listeria Monocytogenes Peritonitis Complicated By Septic Shock In A Patient On Continuous Ambulatory Peritoneal Dialysis, Clinical Nephrology. 2003, 60: 61-62.

Tse K.C., Yip P.S., Lam M.F., Choy C.B.Y., Li F.K., Lui S.L., Lo W.K., Chan D.T.M. and Lai K.N., Star Fruit Intoxication In Uraemic Patients: Case Series And Review Of The Literature, Internal Medicine Journal. 2003, 33: 314-316.

Wang Y., Du Y., Leung J.C.K., Maxwell P., Lai K.N. and Li Y., Megsin 2093TT Genotype Is Associated With A Protective Role In Iga Nephropathy, Journal of the American Society of Nephrology. 2003, 14: 104A.

Yu C.M., Lai K.W.H., Li P.S., Lam K.Y., Leung J.C.K. and Lai K.N., Normalization of renal aquaporin-2 water channel expression by fosinopril, valsartan, and combination therapy in congestive heart failure: a new mechanism of action, Journal of Molecular and Cellular Cardiology. 2004, 36: 445-453.

Researcher : Lai KWH

List of Research Outputs

Yu C.M., Lai K.W.H., Li P.S., Lam K.Y., Leung J.C.K. and Lai K.N., Normalization of renal aquaporin-2 water channel expression by fosinopril, valsartan, and combination therapy in congestive heart failure: a new mechanism of action, Journal of Molecular and Cellular Cardiology. 2004, 36: 445-453.

Researcher : Lai TST

List of Research Outputs

Chan M.M.W., Seto W.H., Sung J.J., Lai T.S.T., Yee W., Yam L.Y.C., Tsang K.W.T., Ip M.S.M., Lam W.K. and Lai K.N., Severe Acute Respiratory Syndrome: Patients Were Epidemiologically Linked, British Medical Journal. 2003, 326: 1393.

Chau T.N., Lee K.C., Yao H., Tsang T.Y., Chow T.C., Yeung Y.C., Choi K.W., Tso Y.K., Lau T., Lai T.S.T. and Lai C.L., SARS-associated Viral Hepatitis Caused By A Novel Coronavirus: Report Of Three Cases, Hepatology. 2004, 39: 302-310.

Researcher : Lam B

List of Research Outputs

Ho J.C.M., Lam W.K., Yan C.P.K., Ip S., Wong M., Lam J., Wang J., Lam C.L., Lam B., Chan M.M.W., Ip M.S.M. and Tsang K.W.T., A phase II study of vinorelbine monotherapy in the treatment of advanced nob-small cell lung cancer in the elderly, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-06.

Ho J.C.M., Lam W.K., Lam B., Wong M.P. and Tsang K.W.T., Clinical outcome for lymphoepithelioma-like carcinoma of the lung cancer after chemoradiotherapy, Lung Cancer. 2003, 41 (suppl 2): S146.

Ho J.C.M., Ooi C.G.C., Mok T.Y., Chan J.W., Hung I., Lam B., Wong P.C., Li P.C., Ho P.L., Lam W.K., Ng C.K., Ip M.S.M., Lai K.N., Chan M.M.W. and Tsang K.W.T., High-dose pulse versus nonpulse corticosteroid regimens in severe acute respiratory syndrome, American Journal of Respiratory and Critical Care Medicine. 2003, 168: 1449-1456.

Ho J.C.M., Wu A.Y.Y., Ooi C.G.C., Lam B., Ho P.L., Chan M.M.W., Ip M.S.M., Lam W.K. and Tsang K.W.T., Pentaglobin as rescue therapy in patients with severe acute respiratory syndrome, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-04.

Ip M.S.M., Lam B., Tang L.C., Lauder I.J., Ip T.Y. and Lam W.K., A community study of sleep-disordered breathing in middle-aged Chinese women in Hong Kong - prevalence and gender differences, Chest. 2004, 125: 127-134.

Ip M.S.M., Tse H.F., Lam B., Tsang K.W.T. and Lam W.K., Endothelial function in obstructive sleep apnea and response to treatment, American Journal of Respiratory and Critical Care Medicine. 2004, 169: 348-353.

Jones B.M., Ma E.S.K., Peiris J.S.M., Wong P.C., Ho J.C.M., Lam B., Lai K.N. and Tsang K.W.T., Prolonged disturbances of in vitro cytokine production in patients with severe acute respiratory syndrome (SARS) treated with ribavirin and steroids, Clinical & Experimental Immunology. 2004, 135: 467-473.

Lam B., Ooi C.G.C., Peh W.C.G., Lauder I.J., Tsang K.W.T., Lam W.K. and Ip M.S.M., Computed tomographic evaluation of the role of craniofacial and upper airway morphology obstructive sleep apnea in Chinese, Respiratory Medicine. 2004, 98: 301-307.

Lam B., Ooi C.G.C., Wong M.P., Lee R., Ip M.S.M., Chan M.M.W., Lam W.K. and Tsang K.W.T., Extrapulmonary presentation of asymptomatic pulmonary lymphangioleiomyomatosis, Respirology. 2003, 8(4): 544-547.

Lam M.F., Ooi C.G.C., Lam B., Ho J.C.M., Seto W.H., Ho P.L., Wong P.C., Liang R.H.S., Lam W.K. and Tsang K.W.T., An indolent case of severe acute respiratory syndrome, American Journal of Respiratory and Critical Care Medicine. 2004, 169(1): 125-128.

Lam W.K., Ho J.C.M., Lam B. and Tsang K.W.T., Severe acute respiratory syndrome (SARS) and impacts on travel, Internal Medicine Journal of Thailand. 2003, 19: 279-286.

Mok W.Y.W., Lam C.L.K., Lam B., Cheung M.T., Yam L.Y.C. and Ip M.S.M., A Chinese version of the Sleep Apnea Quality of Life Index : reliability, validity and responsiveness, Journal of Clinical Epidemiology. 2004, 57(5): 470-478.

Ooi C.G.C., Khong P.L., Lam B., Ho J.C.M., Yiu W.C., Wong R.W.M., Wang T., Ho P.L., Wong P.C., Chan R.H., Lam W.K., Lai K.N. and Tsang K.W.T., Relationship between radiological and clinical parameters in SARS, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia, 2003. Abstract Book: OP2-01, p.73.

Ooi C.G.C., Khong P.L., Muller N.L., Zhou L.J., Ho J.C.M., Lam B., Nicolaou S. and Tsang K.W.T., Sequential HRCT findings in SARS., The 8th Asian Pacific Society of Respirology Congress.. 2003.

Ooi C.G.C., Khong P.L., Lam B., Ho J.C.M., Yiu W.C., Wong R.W.M., Wang T., Ho P.L., Chan R.H., Lam W.K., Lai K.N. and Tsang K.W.T., Severe acute respiratory syndrome : Relationship between radiological and clinical parameters, Radiology. 2003, 229: 492-499.

Ooi C.G.C., Khong P.L., Ho J.C.M., Lam B., Wong R.W.M., Yiu M.W.C., Wong P.C., Wong C.F., Lai K.N. and Tsang K.W.T., Severe acute respiratory syndrome: radiographic evaluation and clinical outcome measures, Radiology. 2003, 229: 500-506.

Ooi C.G.C., Khong P.L., Muller N.L., Yiu W.C., Zhou L.J., Ho J.C.M., Lam B., Nicolaou S. and Tsang K.W.T., Severe acute respiratory syndrome: temporal lung changes at thin-section CT in 30 patients, Radiology. 2004, 230: 836-844.

Wu A.Y.Y., Ooi C.G.C., Lam B., Mok T.Y.M., Ho P.L., Chan M.M.W., Ip M.S.M., Lam W.K. and Tsang K.W.T., The use of pentaglobin in patients with deteriorating severe acute respiratory syndrome, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia . 2003, Abstract Book PP6-15: p.194.

Researcher : Lam CLK

Project Title:	Development of the Chinese (HK) SF-8 health survey
Investigator(s):	Dr. Lam C.L.K., Ms Gandek B.
Department:	Family Medicine Unit of the Department of Medicine
Source(s) of Funding:	Health Assessment Laboratory, U.S.A.
Start Date:	06/2001

Abstract:

To translate the SF-8 health survey to Chinese; to evaluate the equivalence of the meaning of the Chinese SF-8 to those of the original SF-8.

Project Title:	A randomised controlled trial on the effectiveness of screening and brief problem-solving counselling for elderly patients with undiagnosed psychological problems in primary care
Investigator(s):	Dr. Lam C.L.K., Dr. Fong D.Y.T., Dr. Lam T.P., Prof. Lee P.W.H.
Department:	Family Medicine Unit of the Department of Medicine
Source(s) of Funding:	Health Care and Promotion Fund
Start Date:	09/2002

Abstract:

To test if screening followed by brief problem-solving counselling by primary care doctors can improve the health-related quality of life (HRQOL) of elderly patients with previously undiagnosed psychological problems; to find out the effects of undiagnosed psychological problems on HRQOL and consultation rates of elderly patients.

Project Title:	Pilot test on the world health organization quality of life assessment form - OLD module
Investigator(s):	Dr. Lam C.L.K., Dr. Chan A., Mr. Leung K.F.
Department:	Family Medicine Unit of the Department of Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2002
Completion Date:	10/2003

Abstract:

To assess the feasibility and acceptability of QOL assessment by elderly Chinese in Hong Kong; to collect data for psychometric testing in order to identify items that are most discriminative for the measurement of QOL of the elderly; to develop an elderly specific WHOQOL assessment form - the WHOQOL_OLD.

List of Research Outputs

Fraser R...C., Lee R...S...Y., Yiu Y...K., Lam C.L.K., McKinley R...K. and Van de Vleuten C...P...M., Regulatory assessment of the consultation competence of Family Physicians in Hong Kong, Hong Kong Practitioner. Hong Kong, 2004, 26 (1): 5-15.

Ip T...P., Lam C.L.K. and Kung A...W...C., Awareness of osteoporosis among physicians in China, Osteoporosis. 2004, 15: 329-334.

Lam C.L.K., Book Review - The new consultation: developing doctor-patient communication, Family Practice. 2004, 21(1): 117.

Lam C.L.K., Cross-cultural validation and norming of the MOS 36-item Short-form Health Survey (SF-36) on Chinese adults in Hong Kong, Doctor of Medicine Thesis, The University of Hong Kong. Hong Kong, 2003.

Lam C.L.K., Paper on 'The Role of Culture in Quality of Life Assessment: A View from Hong Kong' , 10th International Society for Quality of Life Research (ISOQOL) Annual Meeting. Prague, Czech Republic, 2003.

Lam C.L.K., Plenary paper on 'Criterion-based Assessment of Performance as Summative Assessment of Vocational Training in Family Medicine'., 13th WONCA Asia Pacific Regional Conference, Organized by the National Society of General Practice, China.. Beijing, China, 2003.

Lam C.L.K., Plenary paper on 'Family Medicine Research-Shaping the Future., Family Medicine Symposium 2003, the Chinese University of Hong Kong. Hong Kong, 2003.

Lam C.L.K., Reliability and construct validity of the Chinese (Hong Kong) SF-36 for patients in primary care., Hong Kong Practitioner. Hong Kong, 2003, 25 (10): 468-475.

Lam C.L.K., The 21st Century: The age of family medicine research, Annals of Family Medicine. 2004, 2 (suppl): S50 - S54.

Lam C.L.K. and Lee W.Y., The family may be the rescue when your heart starts to sink., Hong Kong Practitoner. Hong Kong, 2004, 26 (2): 57-58.

Lam C.L.K., The price of cancer screening, Hong Kong Practitioner. Hong Kong, 2004, 26 (3): 142-145.

Lau K.C.J., Fraser R...C. and Lam C.L.K., Establishing the content validity in Hong Kong of the prioritized criteria of consultation competence in the Leicester Assessment Package (LAP), Hong Kong Practitioner. Hong Kong, 2003, 25 (12): 596-602.

Lee R...S...Y., Fraser R...C., Lam C.L.K., Ho K...S. and Li K.T., Effects of SARS on consultations in primary care in Hong Kong., Hong Kong Practitioner. Hong Kong, 2003, 25 (11): 532-541.

Mok W.Y.W., Lam C.L.K., Lam B., Cheung M.T., Yam L.Y.C. and Ip M.S.M., A Chinese version of the Sleep Apnea Quality of Life Index : reliability, validity and responsiveness, Journal of Clinical Epidemiology. 2004, 57(5): 470-478.

Wong R.W.M., Lai K.C., Hui W.M., Lam K.F., Huang J., Hu H.C., Wong Y.H., Lam C.L.K., Xia H.H.X., Chan O.O., Lam S.K. and Wong B.C.Y., Double-blind, Randomized Controlled Study to Assess the Effects of Lansoprazole 30 mg and Lansoprazole 15 mg on 24-h Oesophageal and Intragastric pH in Chinese Subjects with Gastro-Oesophageal Reflux Disease, Alimentary Pharmacology and Therapeutics. 2004, 19(4): 455-62.

Wong R.W.M., Lam K.F., Cheng C., Hui W.M., Xia H.H.X., Lai K.C., Hu H.C., Huang J., Lam C.L.K., Chan C.K., Chan O.O., Lam S.K. and Wong B.C.Y., Population Based Study of Noncardiac Chest Pain in Southern Chinese: Prevalence, Psychosocial Factors and Health Care Utilization, World Journal of Gastroenterology. 2004, 10(5): 707-712.

Wong W.M., Lai K.C., Lam K.F., Hui W.M., Hu H.C., Lam C.L.K., Xia H.H.X., Huang J., Chan C.K., Lam S.K. and Wong B.C.Y., Prevalence, Clinical Spectrum and Health Care Utilization of Gastro-Oesophageal Reflux Disease in a Chinese Population: a Population-Based Study, Alimentary Pharmacology and Therapeutics. 2003, 18(6): 595-604.

Researcher : Lam CW

List of Research Outputs

Chow W.S., Tan K.C.B., Xu A., Lam C.W., Ai V.H.G., Tam S.C.F. and Lam K.S.L., Hypoadiponectinemia is associated with impaired endothelial vasomotor function, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Tan K.C.B., Xu A., Chow W.S., Lam C.W., Ai V.H.G. and Tam S.C.F., Hypoadiponectinemia is associated with impaired endothelial vasomotor function, Journal of Clinical Endocrinology and Metabablism. 2004, 89: 765-769.

Researcher : Lam KSL

Project Title:	Losartan renal protection study
Investigator(s):	Prof. Lam K.S.L., Dr. Wat N.M.S.
Department:	Medicine
Source(s) of Funding:	Merck Research Laboratories, U.S.A.
Start Date:	01/1997

Abstract:

To study the beneficial effect of angiotensin II receptor blockade on renal function of NIDDM patients with moderately severe, diabetic nephropathy.

Project Title:	Genetic and hormonal influences on phenotypic expression of apolipoprotein (a)
Investigator(s):	Prof. Lam K.S.L.
Department:	Medicine
Source(s) of Funding:	Outstanding Researcher Award, Vice-Chancellor's Development Fund
Start Date:	11/1998

Abstract:

To enhance research level.

Project Title:	The role of aldose reductase in the pathogenesis of diabetic nephropathy and atherosclerosis: interaction of polyol pathway with non-enzymatic glycation
Investigator(s):	Prof. Lam K.S.L., Dr. Dan Q.H.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2002

Abstract:

To demonstrate whether aldose reductase (AR) is involved in the pathogenesis of diabetic nephropathy and atherosclerosis; to explore the interaction between polyol pathway and non-enzymatic glycation in the development of (a) diabetic nephropathy and (b) diabetic atherosclerosis.

Project Title:	Clinical, genetic and functional studies of two novel fat-derived hormones
Investigator(s):	Prof. Lam K.S.L., Dr. Wat N.M.S., Dr. Xu A.M.
Department:	Medicine
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	08/2003

Abstract:

To conduct a systematic analysis of the polymorphisms and mutations in the resistin and adiponectin genes in Southern Chinese and to investigate, in cross-sectional and prospective studies, their association with insulin resistance and related disorders including obesity, impaired glucose tolerance, type 2 diabetes, hypertension, dyslipidaemia and carotid atherosclerosis; to determine the relationship of serum resistin to indices of insulin resistance in population studies; to investigate whether circulating adiponectin levels and isoforms, and resistin levels are genetically determined, whether they are predictive of the development of diabetes and hypertension in a 5-year prospective study, and whether they are associated with the development of carotid atherosclerosis; to examine the relationship of circulating adiponectin and resistin to other causes of insulin resistance including age, growth hormone excess and presence of chronic systemic inflammation; to elucidate how the genetic mutations/polymorphisms lead to altered expression and/or functions of resistin and adiponectin using site-directed mutagenesis and functional studies. To investigate whether circulating adiponectin and resistin levels are genetically determined, whether they are predictive of the development of diabetes and hypertension in a 5-year prospective study, and whether they are associated with the development of carotid atherosclerosis.

Project Title:	Clinical, genetic and functional studies of two novel fat-derived hormones
Investigator(s):	Prof. Lam K.S.L., Dr. Wat N.M.S., Dr. Xu A.M.
Department:	Medicine
Source(s) of Funding:	RGC Projects (Block Grant Funded)
Start Date:	08/2003

Abstract:

Project Title:	Adiponectin as a novel diagnostic marker and therapeutic target for the treatment of diabetes, steatohepatitis and other metabolic disorders
Investigator(s):	Prof. Lam K.S.L., Dr. Chao Y.S., Dr. Shen J.G., Dr. Xu A.M.
Department:	Medicine
Source(s) of Funding:	GlaxoSmithKline Ltd.
Start Date:	11/2003

Abstract:

To develop, standardize and evaluate an ultra sensitive and rapid adiponectin assay kit for prognostic assessment of these metabolic disorders in obese populations, for selecting the most effective therapeutic drugs for patients with these health problems; and for monitoring their response to tailored treatment; to use our recently established high-throughout adiponectin promoter assay system to screen for novel drugs from tradtional Chinese medicine and other chemical libraries that can enhance the production of the subject's endogenous adiponectin, which can be used for the treatment of the Metabolic Syndrome (type 2 diabetes, dyslipidemia, fatty liver and atherosclerosis), alcoholic liver injury, and metabolic disorders associated with treatment for HIV infections.

Project Title:	Adiponectin as a novel diagnostic marker and therapeutic target for the treatment of diabetes, steatohepatitis and other metabolic disorders
Investigator(s):	Prof. Lam K.S.L., Dr. Chao Y.S., Dr. Shen J.G., Dr. Xu A.M.
Department:	Medicine
Source(s) of Funding:	Innovation and Technology Fund, Innovation and Technology Commission of Hong Kong Government
Start Date:	11/2003

Abstract:

Project Title:	Autocrine functions of adipokines
Investigator(s):	Prof. Lam K.S.L., Dr. Xu A.M., Dr. Xu J.Y.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2003

Abstract:

To establish a system to stably and efficiently suppress the expression of resistin, adiponectin and adipocyspin in mouse adipocytes using RNA interference; to investigate the autocrine function of these adipolines on adipogenesis, lipolysis, lipogenesis and insulin sensitivity in the gene-knock down cell models.

List of Research Outputs

But B., Chan C.W., Chan F., Chan K.W., Cheng A.W.F., Cheung P., Choi K.L., Chow C.B., Chow F.C.C., Eastman C., Fok T.F., Fung L.M., Gomes C., Huen K.F., Ip T.P., Kung A.W.C., Lam K.S.L., Lam Y.Y., Lao T.T.H., Lee C.Y., Lee K.F., Leung J., Leung N.K., Li D., Li J., Lo K.W., Low L.C.K., Ng K.L., Siu S.C., Tam S.C.F., Tan K.C.B., Tiu S.C., Tse H.Y., Tse W., Wong G., Wong S., Wong W., Yeung V.T.F., Young R., Yu C.M. and Yu R., Consensus statement on iodine deficiency disorders in Hong Kong, Hong Kong Medical Journal. 2003, 9: 446-453.

Chan J.C., Wat N.M.S., So W.Y., Lam K.S.L., Chau C.T., Wong K.S., Morad Z., Dickson T.Z., Hille D., Zhang Z., Cooper M.E., Shahinfar S., Brenner B.M. and Kurokawa K., Rennin angiotensin aldosterone system blockade and renal disease in patients with type 2 diabetes: an Asian perspective from the RENAAL study, Diabetes Care. 2004, 27: 874-9.

Chang A., Chan W.F., Lo C.Y. and Lam K.S.L., Multiple endocrine neoplasia type 2B in a Chinese patient, Hong Kong Medical Journal. 2004, 10(3): 206-209.

Cheung B.M.Y., Lo L.F., Chan S.K., Chan M.Y., Fong D.Y.T., Leung R.K.W., Wong S., Wong V., Lam K.S.L., Lau C.P., Lee P.W.H. and Karlberg J.P.E., Effect of qigong on hypertension: a randomised controlled study, Hong Kong Medical Journal. 2003, 9(1) Suppl: 21.

Cheung B.M.Y., Lam T.H., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Man Y.B., Cheng C.H., Kumana C.R. and Lau C.P., Follow Up of the Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort (CP17), Seventh Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine: Journal of the Hong Kong College of Cardiology . 2003, 11 (Suppl 1).

Cheung B.M.Y., Lam T.H., Lam K.S.L., Tam S.C.F., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Man Y.B., Cheng C.H., Kumana C.R. and Lau C.P., Follow up of the Hong Kong Cardiovascular risk factor prevalence survey cohort, Hong Kong Medical Journal. 2003, 9(1) Suppl: 27.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., High blood pressure is related to obesity in Hong Kong, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., High blood pressure is related to obesity in Hong Kong, Hong Kong Medical Journal. 2003, 9(1) Suppl: 35.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Lipid profile of the Hong Kong cardiovascular risk factor prevalence study cohort, Hong Kong Medical Journal. 2003, 9(1) Suppl: 22.

Cheung B.M.Y., Man Y.B., Lam K.S.L., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Lipid profile of the Hong Kong cardiovascular risk factor prevalence survey cohort, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Obesity in the Hong Kong cardiovascular risk factor prevalence survey-2 (CRISPS2) cohort, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Cheung B.M.Y., Man Y.B., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of Diabetes Mellitus (DM) in the Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort (P16), Seventh Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine: Journal of the Hong Kong College of Cardiology . 2003, 11 (Suppl 1).

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of diabetes mellitus (DM) in the Hong Kong Cardiovascular risk factor prevalence study cohort, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Cheung B.M.Y., Man Y.B., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of diabetes mellitus (DM) in the Hong Kong Cardiovascular risk factor prevalence study cohort, Hong Kong Medical Journal. 2003, 9(1) Suppl: 19.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of obesity in the Hong Kong Cardiovascular risk factor prevalence survey-2 (CRISPS2), Hong Kong Medical Journal. 2003, 9(1) Suppl: 23.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Relationship between Hypertension and Obesity in Hong Kong, 3rd Asian-Pacific Congress of Hypertension. 2004.

Choi K.L., Wang Y., Tse C.A., Lam K.S.L. and Cooper G.J.S., Proteomic analysis of adipocyte differentiation: Evidence that a2 macroglobulin is involved in the adipose conversion of 3T3 L1 preadipocytes, Proteomics Journal. 2004, 4: 1840-8.

Chow W.S., So T., Tan K.C.B., Choy A., Hung V., Hui C.K., Chu D., Chan C.K. and Lam K.S.L., An evaluation of the effectiveness of a step-down clinic for diabetes in Hong Kong, 18th Congress of International Diabetes Federation, 24-29 Aug 2003, Paris, France. 2003, A103(286).

Chow W.S., Tse H.F., Tan K.C.B., Lo K.W., Lee K.F. and Lam K.S.L., Effect of intensifying glycemic control on vasomotor functions in subjects with type 1 diabetes mellitus, American Diabetes Association 64th Scientific Sessions, Orlando , June 2004.

Chow W.S., Tan K.C.B., Xu A., Ai V.H.G., Tam S.C.F. and Lam K.S.L., Hypoadiponectinemia is associated with endothelial dysfunction, 5th Annual Scientific Meeting of Hong Kong Society of Endocrinology, Metabolism and Reproduction, October 2003, Hong Kong. 2003.

Chow W.S., Tan K.C.B., Xu A., Lam C.W., Ai V.H.G., Tam S.C.F. and Lam K.S.L., Hypoadiponectinemia is associated with impaired endothelial vasomotor function, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Chung S.S.M., Ho C.M.E., Lam K.S.L., Lam K.S.L. and Chung S.K., Oxidative stress and diabetic complications, The 3rd International Huaxia Congress of Endocrinology, May 25 – 28, 2004, Shanghai, China. 2004.

Dan Q., Xu A., Cheng K.Y., Xu J. and Lam K.S.L., Adiponectin suppresses the proliferation of human aortic smooth muscle cells induced by advanced glycation and end products, The 3rd International Huaxia Congress of Endocrinology, May 25 – 28, 2004, Shanghai, China. 2004.

Dan Q., Yin S., Chung S.K., Chung S.S.M. and Lam K.S.L., Interaction between the polyol pathway and non-enzymatic glycation on aortic smooth muscle cell migration and monocyte adhesion in a transgenic mouse model, 13th International Symposium on Atherosclerosis, September 28 – October 2, 2003, Kyoto, Japan. 2003.

Dan Q., Yin S., Wong L.C., Chung S.K., Chung S.S.M. and Lam K.S.L., Interaction between the polyol pathway and non-enzymatic glycation on aortic smooth muscle cell migration and monocyte adhesion in a transgenic mouse model, 15th Annual Scientific Meeting of Hong Kong Society of Endocrinology, Metabolism and Reproduction, October 2003, Hong Kon. 2003.

Dan Q., Yin S., Wong L.C., Chung S.K., Chung S.S.M. and Lam K.S.L., Interaction between the polyol pathway and non-enzymatic glycation on aortic smooth muscle cell migration and monocyte adhesion in a transgenic mouse model, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Dan Q., Yin S., Wong L.C., Chung S.K., Chung S.S.M. and Lam K.S.L., Interaction between the polyol pathway and non-enzymatic glycation on aortic smooth muscle cell mirgration and moncyte adhesion in a transgenic mouse model, XIIIth International Symposium on Atherosclerosis, Sep 28-Oct 2, 2003, Kyoto, Japan. European Atherosclerosis Society, 2003, 1P-0137.

Dan Q., Wong L.C., Cheng K.Y., Chung S.S.M., Chung S.K. and Lam K.S.L., The polyol pathway and diabetic atherosclerosis, The 3rd International Huaxia Congress of Endocrinology, May 25 – 28, 2004, Shanghai, China. 2004.

Fong D.Y.T., Kwan C.W., Lam K.F. and Lam K.S.L., Use of the Sign Test for the Median in the Presence of Ties, The American Statistician. 2003, 57(4): 237-240.

Lam K.S.L., Co-Chairman, Scientific Committee, 3rd International Huaxia Congress of Endocrinology. 2004.

Lam K.S.L., Fat Cells, Metabolic syndrome and heart disease, The 3rd International Huaxia Congress of Endocrinology, May 25 – 28, 2004, Shanghai, China. 2004.

Lam K.S.L., Fat cells, metabolic syndrome & heart disease” Plenary lecture, 3rd International Huaxia Congress of Endocrinology, Shanghai, China. 2004.

Lam K.S.L., Identifying cardiovascular risk in patients: the Asian experience with diabetes, MSD Speakers Forum, Bangkok, Thailand. 2003.

Lam K.S.L., Dan Q., Yin S., Wong L.C., Chung S.K. and Chung S.S.M., Interaction between non-enzymatic glycation and the polyol pathway on mesangial cell gene expression in an aldose reductase transgenic mouse model, The 18th International Diabetes Federation Congress, August 24-29, 2003, Paris, France. 2003.

Lam K.S.L., Linking the Metabolic Syndrome to cardiovascular diseases, 15th Annual Scientific Meeting of Hong Kong Society of Endocrinology, Metabolism and Reproduction, October 2003, Hong Kong. 2003.

Lam K.S.L., Obesity as a key player in the Metabolic Syndrome, 13th International Symposium on Atherosclerosis, Kyoto, Japan. 2003.

Lam K.S.L., Xu A., Wat N.M.S., Tso A.W.K. and Ip M.S.M., Obesity as the key player in the Metabolic Syndrome, 13th International Symposium on Atherosclerosis, September 28 – October 2, 2003, Kyoto, Japan.. 2003.

Lam K.S.L., Xu A., Wat N.M.S., Tso A.W.K. and Ip M.S.M., Obesity as the key player in the metabolic syndrome, International Congress Series. 2004, 1262: 542-5.

Lam K.S.L. and Tan K.C.B., Organisation of Care: the 'at risk' person in the community, In: E Ferranini, P Zimmet, R Defronzo and H Keen, International Textbook of Diabetes Mellitus. John Wiley & Son, 2003, 3rd Edition: 1777-1784.

Lam K.S.L., Wat N.M.S., Chow W.S., Tso A.W.K., Thomas G.N. and Lam T.H., The Metabolic Syndrome: clinical implications and managements, Journal of the HK College of Cardiology . 2003, 11(Suppl 2): B39-42.

Lam K.S.L., The metabolic syndrome: Clinical implications and management, 8th Asian Pacific Congress of Cardiac Rehabilitation, Hong Kong. 2003.

Lee K.K., Xu A., Tan K.C.B., Wong L.C., Tiu S.C., Tam S.C.F. and Lam K.S.L., Serum adiponectin is reduced in acromegaly and normalized after correction of growth hormone excess, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Leung G.K.K., Chow W.S., Tan K.C.B., Fan Y.W. and Lam K.S.L., Metastatic melanoma of the pituitary gland, Journal of Neurosurgery. 2003, 99(5): 913-915.

Lo C.Y., Wat N.M.S., Lam K.Y., Tiu S.C., Chan J.K.Y. and Lam K.S.L., Multiple endocrine neoplasia type 2 in Chinese families, Clinical Endocrinology. 2003, 58: 528.

Lo C.Y., Chan W.F., Kung A.W.C., Lam K.Y., Tam S.C.F. and Lam K.S.L., Surgical treatment for primary hyperparathyroidism in Hong Kong: Changes in clinical pattern over 3 decades, Archives of Surgery. 2004, 139(1): 77-82.

Mak C.M., Lam K.S.L., Tan K.C.B., Ma O.C. and Tam S.C.F., Cerebrotendinous xanthomatosis in a Hong Kong Chinese kinship with a novel splicing site mutation IVS6-1 G>T in the sterol 27 hydroxylase gene, Molecular Genetics and Metabolism. 2004, 81: 144-6.

Mak M., Lam K.S.L., Ma O.C., Tso A.W.K. and Tam S.C.F., A novel insprtion 110_111insG creating a stop codon D194x in a Chinese family with X-linked adrenoleukodystrophy, 15th Annual Scientific Meeting of Hong Kong Society of Endocrinology, Metabolism and Reproduction, October 2003, Hong Kong. 2003.

Man Y.B., Cheung B.M.Y., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of hypertension in the Hong Kong cardiovascular risk factor prevalence study cohort, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Rong R., Tao A.W.K., Xu A., Cheung G.C.N., Yeung C., Cheung B.M.Y. and Lam K.S.L., Hypoadiponectinaemia is a risk factor of the metabolic syndrome, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Rong R., Xu A., Cheung B.M.Y., Cheung G.C.N. and Lam K.S.L., Identification of three novel missense mutations of the human melanocortin-4 receptor gene in a Chinese obesity population, ENDO 2004, New Orleans, USA, 16-19 June 2004.

Tam S.C.F., Tan K.C.B., Wat N.M.S., Janus E.D., Lam T.H. and Lam K.S.L., C-reactive protein predicts the deterioration of glycemia in Chinese subjects with impaired glucose tolerance, 18th International Diabetes Federation Congress, Paris, August 2003.

Tan K.C.B., Xu A., Chow W.S., Ai V.H.G., Tam S.C.F. and Lam K.S.L., Association between adiponectin and endothelial dysfunction, XIIIth International Symposium on Atherosclerosis, Sep 28-oct 2, 2003, Kyoto, Japan. European Atherosclerosis Society, 2003, 1P-0167.

Tan K.C.B., Xu A., Shiu S.W.M. and Lam K.S.L., Association between adiponectin and hepatic lipase activity, American Diabetes Association 64th Scientific Sessions, Orlando , June 2004.

Tan K.C.B., Wat N.M.S., Tam S.C.F., Janus E.D., Lam T.H. and Lam K.S.L., C-reactive protein predicts the deterioration of glycaemia in Chinese subjects with impaired glucose tolerance, Diabetes Care. 2003, 26: 2323-2328.

Tan K.C.B., Tso A.W.K., Chow W.S., Ma O.C.K., Pang W.C., Tam S.C.F. and Lam K.S.L., Determinants of postprandial triglyceride and remnant-like lipoproteins in type 2 diabetes, he 4th Congress of Asian Pacific Society of Atherosclerosis and Vascular Diseases. Bali, May 2004 . 2004.

Tan K.C.B., Pang R.W.C., Tiu S.C. and Lam K.S.L., Effects of treatment with Sandostatin LAR on lipoprotein metabolism in patients with acromegaly, Clinical Endocrinology. 2003, 59: 558-564.

Tan K.C.B., Xu A., Chow W.S., Ai V.H.G., Tam S.C.F. and Lam K.S.L., Hypoadiponectinemia is associated with impaired endothelium-dependent vasodilatation, Journal of Endocrinology and Metabolism. 2004, 89: 765-9.

Tao A.W.K., Wat N.M.S., Xu A., Rong R., Cheng K.Y., Fong H.Y., Janus E.D. and Lam K.S.L., The adiponectin gene T45G polymorphism is associated with central obesity and glucose intolerance in southern Chinese, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Tso A.W.K., Wat N.M.S., Janus E.D., Wong L.C., Tan K.C.B. and Lam K.S.L., Effect of endothelial nitric oxide synthase polymorphism (GLU298Asp) on the progression of glycaemia in Chinese subjects with impaired glucose tolerance, 15th Annual Scientific Meeting of Hong Kong Society of Endocrinology, Metabolism and Reproduction, October 2003, Hong Kong. 2003.

Tso A.W.K., Wat N.M.S., Janus E.D., Wong L.C., Tan K.C.B. and Lam K.S.L., Effect of endothelial nitric oxide synthase polymorphism (Glu298Asp) on the progression of glycaemia in Chinese subjects with impaired glucose tolerance, 18th International Diabetes Federation Congress, Paris, August 2003.

Tso A.W.K., Rong R., Lo C.Y., Tan K.C.B., Tiu S.C., Wat N.M.S., Xu J., Villablanca A., Larsson C., Teh B.T. and Lam K.S.L., Multiple endocrine neoplasia type 1 (MEN 1): genetic and clinical analysis in Southern Chinese, Clinical Endocrinology. 2003, 59: 129-35.

Xu A., Yin S., Wong L.C., Chan K.W. and Lam K.S.L., Adiponectin ameliorates dyslipidemia induced by the human immunodeficiency virus protease inhibitor ritonavir in mice, Endocrinology . 2004, 145: 487-94.

Xu A., Wong L.C. and Lam K.S.L., Growth hormone enhances adiponectin gene expression via P38 MAP kinase pathway in 3T3-L1 adipocytes, ENDO 2004, New Orleans, USA, 16-19 June 2004.. 2004.

Xu A., Lam K.S.L., Wang Y., Choi L.U.K. and Cooper G...S., Proteomic Analysis Of Adipocyte Differentiation: Evidence That Alpha2 Macroglobulin Is Involved In The Adipose Conversion Of 3t3 L1 Preadipocytes, Proteomics. 2004, 4: 1840-1848.

Xu A., Wong W., Wang Y., Cooper G.J.S. and Lam K.S.L., Proteomic and functional characterization of endogenous adiponectin purified from fetal bovine serum, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Xu A., Yin S., Wong L.C., Chan K.W. and Lam K.S.L., The fat-derived hormone adiponectin ameliorates dyslipidemia induced by HIV protease inhibitors, 13th International Symposium on Atherosclerosis, September 28 – October 2, 2003, Kyoto, Japan. 2003.

Xu A., Yin S., Wong L.C., Chan K.W. and Lam K.S.L., The fat-derived hormone adiponectin ameliorates dyslipidemia induced by HIV protease inhibitors, 15th Annual Scientific Meeting of Hong Kong Society of Endocrinology, Metabolism and Reproduction, October 2003, Hong Kong. 2003.

Xu A., Yiu S., Wong L.Y.F., Chan W.K. and Lam K.S.L., The fat-derived hormone adiponectin ameliorates dyslipidemia induced by HIV protease inhibitors, XIII International Symposium on Atherosclerosis, September 28-October 2, 2003, Kyoto, Japan . The European Atherosclerosis Society, 2003, Sep 2003: 242 (3P-0821*).

Xu J., Dan Q., Chan V.N.Y., Wat N.M.S., Tam S.C.F., Tiu S.C., Lee K.F., Siu S.C., Tsang M.W., Fung L.M., Chan K.W. and Lam K.S.L., Genetic and clinical characteristics of maturity-onset diabetes of the young in Chinese patient, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Yin S., Pan C., Xu A. and Lam K.S.L., C/EBP play an important role in adiponectin gene expression, The 3rd International Huaxia Congress of Endocrinology, May 25 – 28, 2004, Shanghai, China. 2004.

Researcher : Lam KY

List of Research Outputs

Yu C.M., Lai K.W.H., Li P.S., Lam K.Y., Leung J.C.K. and Lai K.N., Normalization of renal aquaporin-2 water channel expression by fosinopril, valsartan, and combination therapy in congestive heart failure: a new mechanism of action, Journal of Molecular and Cellular Cardiology. 2004, 36: 445-453.

Researcher : Lam SK

Project Title:	To measure the gastroduodenal mucosal blood flow, nitric oxide and prostaglandin content of the gastric mucosa at different phases of healing of duodenal ulcer, before and after eradication of Helicobacter pylori (HP)
Investigator(s):	Prof. Lam S.K., Dr. Cho C.H., Dr. Hui W.M., Dr. Lau K.K.
Department:	Faculty of Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	07/1996

Abstract:

To measure the gastroduodenal mucosal blood flow, nitrous oxide and prostaglandin content of the gastric mucosa at different phases of healing of duodenal ulcer, before and after eradication of Helicobacter pylori (HP).

Project Title:	Chemoprevention of gastric cancer by intervention with Helicobacter pylori and cyclooxygenase pathway
Investigator(s):	Prof. Lam S.K., Dr. Wong B.C.Y., Prof. Xu G.W.
Department:	Faculty of Medicine
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	12/2001

Abstract:

To assess if the combination of treatment of Helicobacter pylori infection and use of specific cyclooxygenase-2 inhibitors in asymptomatic individuals can reduce the incidence of gastric cancer in a high risk area over a five to ten year period; to assess if the combination of treatment of Helicobacter pylori infection and use of specific cyclooxygenase-2 inhibitors will lead to progression or regression of various precancerous gastric conditions including gastric atrophy, intestinal metaplasia and dysplasia over a three year period; to assess the long term sequelae of Helicobacter pylori eradication and use of specific cyclooxygenase-2 inhibitors histologically, including changes in cell proliferation, apoptosis and oncogene expressions.

Project Title:	Gene therapy for GI cancer by targeting survivin with adeno-associated virus
Investigator(s):	Prof. Lam S.K., Dr. Tu S.P., Dr. Wong B.C.Y.
Department:	Faculty of Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	01/2003

Abstract:

To study on the effect of rAAv-Survivin.As and rAAV-mutant Survivin on apoptosis and tumor growth in digestive cancers.

Project Title:	Biotech Company in the Faculty of Medicine, The University of Hong Kong
Investigator(s):	Prof. Lam S.K.
Department:	Faculty of Medicine
Source(s) of Funding:	HKU Foundation Seed Grant
Start Date:	07/2003

Abstract:

To enable the Faculty of Medicine of The University of Hong Kong to establish itself as the regional centre of excellence in the provision of complete solutions to industry from laboratory research services to clinical trials, setting standards and quality benchmarks comparable to the best international practices for other similar centres in the region to follow.

Project Title:	c-Jun NH2-terminal kinase 1 modulates apoptosis of gastric cancer cells through the upregulation of XAF1
Investigator(s):	Prof. Lam S.K., Dr. Wong B.C.Y.
Department:	Faculty of Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	02/2004

Abstract:

To elucidate the regulation of XAF1 expression in cancer cells by JNK1; to define the role of JNK1 in the upregulations of XAF1 of cancer cells induced by various stimuli; to provide insight into the role of the interaction between JNK1 and IAP family proteins in the occurrence of apoptosis of cancer cells.

List of Research Outputs

Chan O.O., Wong W.M., Lam S.K. and Wong B.C.Y., Prevention of Gastric Cancer, Chinese Journal of Digestive Diseases. 2003, 4: 100-104.

Chan O.O., Peng J., Lam S.K., Hui W.M., Wong R.W.M., Yuen M.F., Kwong Y.L., Rashid A. and Wong B.C.Y., Reveral of E-Cadherin Promoter Hypermethylation Status after Helicobacter pylori Eradication, Gastroenterology. 2004, 126 (4 Suppl 2): 333.

Cheng C., Chan O.O., Hui W.M. and Lam S.K., Coping Strategies, Illness Perception, Anxiety and Depression of Patients with Idiopathic Constipation: a Population-Based Study, Alimentary Pharmacology and Therapeutics. 2003, 18(3): 319-26.

Ho J.C.M., Wong R.W.M., Ooi C.G.C., Mok T.Y., Hung I.F., Ng W., Lam Y.M., Tam W.O., Wong P.C., Ho P.L., Lai C.L., Lam W.K., Lam S.K. and Tsang K.W.T., Correlation of Liver Dysfunction And Disease Activity In Patients With Severe Acute Respiratory Syndrome, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-08.

Hui C.K., Yuen M.F., Wong W.M., Lam S.K. and Lai C.L., Mirtazapine Induced Hepatotoxicity, Journal of Clinical Gastroenterology. 2003, 35(3): 270-271.

Hui C.K., Lai K.C., Yuen M.F., Wong R.W.M., Chan O.O., Ng M.M.T., Chan C.K., Cheung W.W., Lam S.K., Lai C.L. and Wong B.C.Y., The Role of Cholecystectomy in Reducing Recurrent Gallstone Pancreatitis, Endoscopy. 2004, 36(3): 206-11.

Lai K.C., Lam S.K., Chu K.M., Hui W.M., Kwok K.F., Wong B.C.Y., Hu H.C., Wong R.W.M., Chan O.O. and Chan C.K., Lansoprazole Reduces Ulcer Relapse after Eradication of Helicobacter pylori in Nonsteroidal Anti-Inflammatory Drug Users--a Randomized Trial, Alimentary Pharmacology and Therapeutics. 2003, 18(8): 829-36.

Lam S.K., Asian Pacific Consensus Meeting on GERD: Pathogenesis of GERD, Asian Pacific Digestive Week, Singapore (September 27-30, 2003). 2003.

Lam S.K., Can Our Nation Become Gastric-Cancer Free?, 6th National Conference of Gastric Disease of China, Xiamen (March 5-7, 2004). 2004.

Lam S.K., Eisai Satellite Symposium, Asian Pacific Digestive Week, Singapore (September 27-30, 2003). 2003.

Lam S.K., Interventional Studies in GCA, Annual Scientific Meeting of the Malaysian Society of Gastroenterology & Hepatology, Penang (June 24-27, 2004). 2004.

Lam S.K., Pathogenesis of Gastric Cancer – a Unifying Concept, Annual Scientific Meeting of the Malaysian Society of Gastroenterology & Hepatology, Penang (June 24-27, 2004). 2004.

Lam S.K., Pathogenesis of Gastric Cancer, 1st Beijing Digestive Disease Forum, Beijing (June 17-20, 2004). 2004.

Lam S.K., Presidential Paper Oral Presentation, Asian Pacific Digestive Week, Singapore (September 27-30, 2003). 2003.

Lam S.K., The Okuda Lecture: The Role of Cyclo-oxygenase (COX) in GI Diseases, Asian Pacific Digestive Week, Singapore (September 27-30, 2003). 2003.

Lam S.K. and Wong B.C.Y., The Role of Cyclooxygenase in Gastrointestinal Diseases, Journal of Gastroenterology and Hepatology. 2003, 18(Suppl): A5.

Lam S.K., Young Investigator's Award Presentation, Asian Pacific Digestive Week, Singapore (September 27-30, 2003). 2003.

Li G., Xia H.H.X., Chen M.H., Peng J., Gu Q., Cui J., Cho C.H., Lam S.K., Lin M.C., Berg D.E., Feng Z., Langenbach R., Kung H. and Wong B.C.Y., Cyclooxygenase-2 Gene Disruption Enhances Gastric Inflammation but Inhibits Gastric Epithelial Proliferation Induced by H. pylori Infection, Gastroenterology. 2004, 126 (4 Suppl 2): W907.

Tu S., Chan O.O., Lin M.C., Jiang X., Lam S.K., Kung H. and Wong B.C.Y., Livin, a Novel Member of Inhibitor of Apoptosis, Is Marker of Poor Prognosis in Gastric Cancer, Gastroenterology. 2004, 126 (4 Suppl 2): T1256.

Tu S., Jiang X., Lin M.C., Cui J., Yang Y., Lum C.T., Zou B., Zhu Y.B., Jiang S.H., Wong W.M., Chan O.O., Yuen M.F., Lam S.K., Kung H. and Wong B.C.Y., Suppression of Survivin Expression Inhibits in vivo Tumorigenicity and Angiogenesis in Gastric Cancer, Cancer Research. 2003, 63(22): 7724-7732.

Wang J., Gu Q., Xia H.H.X., Tu S., Peng J., Yang Y., Zou B., Lin M.C., Kung H., Lam S.K. and Wong B.C.Y., JNK1 Up-Regulates the Expression of XIAP-Associated Factor 1 (XAF1) by a P53-Dependent Pathway in Gastrointestinal Cancer, Gastroenterology. 2004, 126 (4 Suppl 2): M946.

Wang W., Huang J., Zheng G., Lam S.K., Karlberg J.P.E. and Wong B.C.Y., Non-Steroidal Anti-Inflammatory Drug Use and the Risk of Gastric Cancer: A Systematic Review and Meta-Analysis, Journal of the National Cancer Institute. 2003, 95(23): 1784-1791.

Wong B.C.Y., Wong R.W.M., Cheung K.L., Tong S.M., Rozen P., Young G.P., Chu K.W., Ho J.W.C., Law W.L., Tung H.M., Lai K.C., Hu H.C., Chan C.K. and Lam S.K., A Sensitive Guaiac Fecal Occult Blood Test is Less Useful than an Immunochemical Test for Colorectal Cancer Screening in a Chinese Population , Alimentary Pharmacology and Therapeutics. 2003, 18(9): 941-946.

Wong B.C.Y., Jiang X., Lin M.C., Tu S., Cui J., Jiang S.H., Wong R.W.M., Yuen M.F., Lam S.K. and Kung H., Cyclooxygenase-2 Inhibitor (SC-236) Suppresses Activator Protein-1 through c-Jun NH2-Terminal Kinase, Gastroenterology. 2004, 126: 136-147.

Wong B.C.Y., Lam S.K., Wong R.W.M., Chen J.S., Zheng T., Feng R., Lai K.C., Hu H.C., Yuen S.T., Leung S.Y., Fong D.Y.T., Ho J.C.Y., Ching C.K. and Chen J.S., Helicobacter pylori Eradication to Prevent Gastric Cancer in a High-Risk Region of China: a Randomized Controlled Trial, The Journal of American Medical Association. 2004, 291(2): 187-194.

Wong B.C.Y., Lam S.K., Wong R.W.M., Chen J.S., Zheng T., Feng R., Lai K.C., Hu H.C., Yuen S.T., Leung S.Y., Fong D.Y.T., Ho J.W.C. and Ching C.K., Helicobacter pylori eradication to prevent gastric cancer in a high-risk region in China: A randomized controlled trial, JAMA. 2004, 291(2): 187-194.

Wong R.W.M., Lai K.C., Hui W.M., Lam K.F., Huang J., Hu H.C., Wong Y.H., Lam C.L.K., Xia H.H.X., Chan O.O., Lam S.K. and Wong B.C.Y., Double-blind, Randomized Controlled Study to Assess the Effects of Lansoprazole 30 mg and Lansoprazole 15 mg on 24-h Oesophageal and Intragastric pH in Chinese Subjects with Gastro-Oesophageal Reflux Disease, Alimentary Pharmacology and Therapeutics. 2004, 19(4): 455-62.

Wong R.W.M., Lai K.C., Hui W.M., Hu H.C., Huang J., Wong Y.H., Xia H.H.X., Chan O.O., Lam S.K. and Wong B.C.Y., Pathophysiology of Gastro-oesophageal Reflux Diseases in Chinese – Role of Transient Lower Oesophageal Sphincter Relaxation and Oesophageal Motor Dysfunction, Gastroenterology. 2004, 126 (4 Suppl 2): T1724.

Wong R.W.M., Lam K.F., Cheng C., Hui W.M., Xia H.H.X., Lai K.C., Hu H.C., Huang J., Lam C.L.K., Chan C.K., Chan O.O., Lam S.K. and Wong B.C.Y., Population Based Study of Noncardiac Chest Pain in Southern Chinese: Prevalence, Psychosocial Factors and Health Care Utilization, World Journal of Gastroenterology. 2004, 10(5): 707-712.

Wong W.M., Gu Q., Wang W., Fung F.M.Y., Berg D.E., Lai K.C., Xia H.H.X., Hu H.C., Chan C.K., Chan O.O., Yuen M.F., Hui C.K., Lam S.K. and Wong B.C.Y., Effects of Primary Metronidazole and Clarithromycin Resistance to Helicobacter pylori on Omeprazole, Metronidazole, and Clarithromycin Triple-Therapy Regimen in a Region with High Rates of Metronidazole Resistance, Clinical Infectious Diseases. 2003, 37(7): 882-9.

Wong W.M., Lam S.K., Tong S.M., Cheung K.L., Tang V.S.Y., Xia H.H.X., Lai K.C., Hu H.C., Chan C.K., Yuen M.F., Chan O.O. and Wong B.C.Y., Evaluation of a Rapid Stool Antigen Test for the Diagnosis of Helicobacter pylori Infection in Chinese Patients, Chinese Journal of Digestive Diseases. 2003, 4: 132-135.

Wong W.M., Lai K.C., Lam K.F., Hui W.M., Hu H.C., Lam C.L.K., Xia H.H.X., Huang J., Chan C.K., Lam S.K. and Wong B.C.Y., Prevalence, Clinical Spectrum and Health Care Utilization of Gastro-Oesophageal Reflux Disease in a Chinese Population: a Population-Based Study, Alimentary Pharmacology and Therapeutics. 2003, 18(6): 595-604.

Wong W.M., Ho J.C.M., Hung I.F., Ng W., Lam Y.M., Tam W.O., Wong B.C.Y., Wong P.C., Lai C.L., Lam W.K., Lam S.K., Tsang K.W.T., Ooi C.G.C., Ho P.L., Mok T. and Chan J., Temporal Patterns of Hepatic Dysfunction and Disease Severity in Patients with SARS, Journal of the American Medical Association Southeast Asia (JAMA). 2003, 290(20): 2663-2665.

Yang Y., Lin M.C., Ching Y.P., Lam S.K., Xia H.H.X., Tu S., Zou B., Wang J., Li G., He H., Gu Q., Peng J., Kung H. and Wong B.C.Y., FHL2 As a Co-Factor of XAF1 in the Induction of Apoptosis, Gastroenterology. 2004, 126 (4 Suppl 2): S938.

Zou B., Lin M.C., Lam S.K., Tu S., Yang Y., Wang J., He H., Peng J., Kung H. and Wong B.C.Y., Hypermethylation Status Around Exon 1 of XIAP-Associated Factor 1 in Human Gastric and Colon Cancer Cell Lines, Gastroenterology. 2004, 126 (4 Suppl 2): T981.

Researcher : Lam TP

Project Title:	What are the effects of the new medical curriculum on our students?
Investigator(s):	Dr. Lam T.P., Prof. Chan Y.S., Dr. Cheng Y.H., Dr. Khoo U.S.
Department:	Family Medicine Unit of the Department of Medicine
Source(s) of Funding:	Run Run Shaw Research and Teaching Endowment Fund
Start Date:	01/2002

Abstract:

To examine teachers' perceptions of final year medical students before and after curriculum reform at the University of Hong Kong.

Project Title:	Why do primary care doctors undertake postgraduate studies in Hong Kong?
Investigator(s):	Dr. Lam T.P., Dr. Lam K.F., Dr. Tse E.Y.Y.
Department:	Family Medicine Unit of the Department of Medicine
Source(s) of Funding:	Run Run Shaw Research and Teaching Endowment Fund
Start Date:	11/2003

Abstract:

To examine the factors which motivate primary care doctors to undertake postgraduate courses in Hong Kong.

List of Research Outputs

Chung J., Wun Y.T. and Lam T.P., Vocational Training in Family Medicine: the Trainers' Perspectives, Hong Kong Practitioner. 2004, 26: 181-186.

Lam T.P., "Medical writing", A workshop presentation together with Prof Barry Weiss, Dr Lyn Clearihen and Prof Zorayda Leopando at Wonca Asia Pacific Regional Conference. Beijing, 2003.

Lam T.P., Co-Editor of Asia Pacific Family Medicine - the Official Journal of Wonca Asia Pacific. 2004.

Lam T.P., Learning after medical school, Hong Kong Practitioner. 2004, 26: 169-170.

Lam T.P., Cheng Y.H. and Chan Y.L., Low literacy Chinese patients: how do they cope? A qualitative study, BioMed Central Public Health. 2004, 4: 14.

Lam T.P., Member of Expert Committee on Regulation of Health Claims, Department of Health, Hong Kong SAR Government. 2003.

Lam T.P., The first batch of graduates of a new medical curriculum in Asia: how do the teachers see them?, 9th Medical Research Conference, The University of Hong Kong. 2004.

Lam T.P., Clearihan L. and Leopando Z., The moving on of Asia Pacific Family Medicine, Asia Pacific Family Medicine. 2003, 2: 187.

Lam T.P., The setting up of a diploma course in community psychological medicine for primary care doctors, Wonca Asia Pacific Regional Conference. Beijing, 2003.

Takemura Y. and Lam T.P., The education of family medicine in Hong Kong, Japanese Journal of Family Practice. 2003, 10(2): 68-69.

Researcher : Lam WK

List of Research Outputs

Cai K., Sham M.H., Tam P.K.H., Lam W.K. and Xu R., Lung cancer gene therapy, Gene Therapy and Molecular Biology. 2003, 7: 245-262.

Chan M.M.W., Lam W.K., Mak J.C.W., Ho S.P., Chan R.H.W., Tsang K.W.T., Ip M.S.M., Ho J.C.M., Wong M.P. and Tan-Un K.C., Polymorphisms of CYP and GST genes, passive smoke and lung cancer risk in Hong Kong Chinese, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-11.

Chan M.M.W., Seto W.H., Sung J.J., Lai T.S.T., Yee W., Yam L.Y.C., Tsang K.W.T., Ip M.S.M., Lam W.K. and Lai K.N., Severe Acute Respiratory Syndrome: Patients Were Epidemiologically Linked, British Medical Journal. 2003, 326: 1393.

Choi K.C., Wong M.P., Tam Y.S.I., Lam C.L., Lam W.K., Wang E., Chau W.S., Chiu S.W. and Chung L.P., Angiogenic activity and angiogenesis-related factor expression in non-small cell lung cancers, Proceedings of the 10th Hong Kong International Cancer Congress, 19-21 November 2003.

Ho J.C.M., Lam W.K., Yan C.P.K., Ip S., Wong M., Lam J., Wang J., Lam C.L., Lam B., Chan M.M.W., Ip M.S.M. and Tsang K.W.T., A phase II study of vinorelbine monotherapy in the treatment of advanced nob-small cell lung cancer in the elderly, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-06.

Ho J.C.M., Lam W.K., Lam B., Wong M.P. and Tsang K.W.T., Clinical outcome for lymphoepithelioma-like carcinoma of the lung cancer after chemoradiotherapy, Lung Cancer. 2003, 41 (suppl 2): S146.

Ho J.C.M., Wong R.W.M., Ooi C.G.C., Mok T.Y., Hung I.F., Ng W., Lam Y.M., Tam W.O., Wong P.C., Ho P.L., Lai C.L., Lam W.K., Lam S.K. and Tsang K.W.T., Correlation of Liver Dysfunction And Disease Activity In Patients With Severe Acute Respiratory Syndrome, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-08.

Ho J.C.M., Ooi C.G.C., Mok T.Y., Chan J.W., Hung I., Lam B., Wong P.C., Li P.C., Ho P.L., Lam W.K., Ng C.K., Ip M.S.M., Lai K.N., Chan M.M.W. and Tsang K.W.T., High-dose pulse versus nonpulse corticosteroid regimens in severe acute respiratory syndrome, American Journal of Respiratory and Critical Care Medicine. 2003, 168: 1449-1456.

Ho J.C.M., Tipoe G.L., Zheng L., Leung T.M., Tsang K.W.T., Shum D.K.Y., Lau W.C.S., Mak J.C.W., Lam W.K. and Ip M.S.M., In vitro study of regulation of IL-6 production in bronchiectasis, Respiratory Medicine. 2004, 98: 334-341.

Ho J.C.M., Ooi C.G.C., Mok T.Y.M., Ho P.L., Chan M.M.W., Ip M.S.M., Lam W.K. and Tsang K.W.T., Initial pulse or non-pulse steroid therapy in patients with deteriorating severe acute respiratory syndrome, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia,2003. Abstract book PP6-14: p.193.

Ho J.C.M., Lam W.K., Ip S., Wong M. and Chan M.M.W., Local experience in the treatment of advanced lymphoepithelioma-like carcinoma of the lung, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-07.

Ho J.C.M., Lam W.K., Ooi C.G.C., Wong M.P., Lam J.C., Ip M.S.M. and Tsang K.W.T., Lymphoepithelioma-like carcinoma of the lung in a patient with silicosis, European Respiratory Journal . 2003, 22(2): 383-386.

Ho J.C.M., Ho S.P., Chan M.M.W., Mak J.C.W., Ip M.S.M., Wong M.P., Tsang K.W.T. and Lam W.K., Non-small cell lung cancer in Chinese is associated with disturbance in systemic antioxidants profiles , 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-03.

Ho J.C.M., Wu A.Y.Y., Ooi C.G.C., Lam B., Ho P.L., Chan M.M.W., Ip M.S.M., Lam W.K. and Tsang K.W.T., Pentaglobin as rescue therapy in patients with severe acute respiratory syndrome, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-04.

Ho J.C.M., Ooi C.G.C., Mok T.Y., Ho P.L., Chan M.M.W., Ip M.S.M., Lam W.K. and Tsang K.W.T., Pulse corticosteroid therapy in patients with severe acute respiratory syndrome, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-05.

Ho J.C.M., Ho S.P., Chan M.M.W., Ip M.S.M., Wong M.P., Tsang K.W.T. and Lam W.K., Systemic antioxidant profiles in non-small cell lung cancer in Chinese, The Journal of the Japanese Respiratory Society. 2004, 42 (suppl): 69.

Ip M.S.M., Lam B., Tang L.C., Lauder I.J., Ip T.Y. and Lam W.K., A community study of sleep-disordered breathing in middle-aged Chinese women in Hong Kong - prevalence and gender differences, Chest. 2004, 125: 127-134.

Ip M.S.M., Tse H.F., Lam B., Tsang K.W.T. and Lam W.K., Endothelial function in obstructive sleep apnea and response to treatment, American Journal of Respiratory and Critical Care Medicine. 2004, 169: 348-353.

Lam B., Ooi C.G.C., Peh W.C.G., Lauder I.J., Tsang K.W.T., Lam W.K. and Ip M.S.M., Computed tomographic evaluation of the role of craniofacial and upper airway morphology obstructive sleep apnea in Chinese, Respiratory Medicine. 2004, 98: 301-307.

Lam B., Ooi C.G.C., Wong M.P., Lee R., Ip M.S.M., Chan M.M.W., Lam W.K. and Tsang K.W.T., Extrapulmonary presentation of asymptomatic pulmonary lymphangioleiomyomatosis, Respirology. 2003, 8(4): 544-547.

Lam C.L., Wong M.P., Lam W.K., Chung L.P., Chiu S.W., Chau W.S., Ho K.K. and Minna J.D., Quantitative comparison of expression of nicotinic acetylcholine receptor (nAChR)subunits between non-small cell lung cancers (NSCLCs) arising in life-time never-smokers and smokers in Chinese patients , Research Postgraduate Symposium Presentation, The University of Hong Kong. 2003, Abstract Book.

Lam D.C.L., Wong M.P., Chung L.P., Girard L., Lam W.K. and Minna J.D., Expression profiling with microarray in studying differential gene expression in different primary lung cancer cell lines newly established from local Chinese patients, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-15.

Lam D.C.L., Wong M.P., Lam W.K., Chung L.P., Chiu S.W., Chau W.S., Ho K.K. and Minna J.D., Quantitative comparison of expression of nicotinic acetylcholine receptor (nAChR)subunits between non-small cell lung cancer (NSCLC) arising in life-time never-smokers in Chinese patients , Lung Cancer. 2003, 41 (suppl 2): S89.

Lam D.C.L., Wong M.P., Lam W.K., Chung L.P., Chiu S.W., Chau W.S., Ho K.K. and Minna J.D., Quantitative comparison of nicotinic acetylcholine receptor subunit expression level reveals differences in non-small cell lung cancer arising fron life-time never-smokers and smokers, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-14.

Lam M.F., Ooi C.G.C., Lam B., Ho J.C.M., Seto W.H., Ho P.L., Wong P.C., Liang R.H.S., Lam W.K. and Tsang K.W.T., An indolent case of severe acute respiratory syndrome, American Journal of Respiratory and Critical Care Medicine. 2004, 169(1): 125-128.

Lam W.K., After SARS, Asian Pacific Society of Respirology Newsletter. 2003, 12(2): 3-4.

Lam W.K., GOLD : Global Initiative for Obstructive Lung Diseases Executive Summary (Revised), GOLD 2003 World COPD Day CD-ROM Preface. 2003. 2003.

Lam W.K., Lung Cancer (in Chinese), Anti-Cancer Society. 2003, (8-page leaflet).

Lam W.K., Lung Cancer in Women : the Asian Perspective, The Journal of the Japanese Respiratory Society. 2004, 42 (suppl): 44.

Lam W.K., Message from the President, Asian Pacific Society of Respirology Newsletter. 2003, 12(1): 1.

Lam W.K., New strategies in the diagnosis and staging of lung cancer, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia . 2003, Symposium S7A-3: p.51.

Lam W.K., New strategies in the mediastinal staging of non-small cell lung cancer, Proceedings of the 8th Congress of the Asian Pacific Society of Respirology. Blackwell Publishing Asia, 2003, p.41-44.

Lam W.K., Zhong N.S. and Tang W.C., Overview on Severe Acute Respiratory Syndrome in Asia and the world, Respirology. 2003, 8: S2-S5.

Lam W.K., Ho J.C.M., Lam B. and Tsang K.W.T., Severe acute respiratory syndrome (SARS) and impacts on travel, Internal Medicine Journal of Thailand. 2003, 19: 279-286.

Lam W.K. and Tsang K.W.T., Severe acute respiratory syndrome : what lessons have been learnt?, e-Bulletin of The Royal College of Physicians of Edinburgh (www.rcpe.ac.uk/fellows/Bulletin/breaking news/bn_extra_SARS lessons.html). 2004.

Lam W.K., The Michiyoshi Harasawa and Ann J Woolcock memorial lectures, Respirology. 2003, 8: 118.

Lam W.K. and Tsang K.W.T., The severe acute respiratory syndrome (SARS) outbreak - what lessons have been learnt? , Journal of the Royal College of Physicians of Edinburgh. 2004, 34: 90-93.

Leung W.C.H., Ooi C.G.C., Mak J.C.W., Leung Y.H., Leung K.M., Lam W.K., Tsang K.W.T. and Tipoe G.L., Animal model of bronchiectasis, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: A-06.

Li T.C., Wong M.P., Tam Y.S.I., Lam C.L., Lam W.K., Wang E., Chau W.S., Chiu S.W. and Chung L.P., Promoter hypermethylation of MGMT, RARB, DAPK and CDH13 genes in non-small cell lung cancers (NSCLC) in Hong Kong, Proceedings of the 10th Hong Kong International Cancer Congress, 19-21 November 2003.

Mak J.C.W., Hui W.S., Lam W.K. and Tsang K.W.T., Role of pseudomonas aeruginosa pyocyanin in mediating cytokine release in human airway epithelial cells in vitro , 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia. 2003, Abstract Book PP7-05: p.220.

Mak J.C.W., Hui W.S., Pan N.Y., Lam W.K. and Tsang K.W.T., Role of pseudomonas aeruginosa pyocyanin in mediating cytokine release in human airway epithelial cells in vitro, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-02.

Ooi C.G.C., Khong P.L., Lam B., Ho J.C.M., Yiu W.C., Wong R.W.M., Wang T., Ho P.L., Wong P.C., Chan R.H., Lam W.K., Lai K.N. and Tsang K.W.T., Relationship between radiological and clinical parameters in SARS, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia, 2003. Abstract Book: OP2-01, p.73.

Ooi C.G.C., Khong P.L., Lam B., Ho J.C.M., Yiu W.C., Wong R.W.M., Wang T., Ho P.L., Chan R.H., Lam W.K., Lai K.N. and Tsang K.W.T., Severe acute respiratory syndrome : Relationship between radiological and clinical parameters, Radiology. 2003, 229: 492-499.

Ooi C.G.C., Tsang K.W.T., Cheung R.T.F., Khong P.L., Ho I.W.T., Ip M.S.M., Tan C.M., Ngan H., Lam W.K., Chan F.L. and Chan M.M.W., Silicosis in 76 men: qualitative and quantitative CT evaluation - clinical-radiologic correlative study., Radiology . 2003, 228(3): 816-25.

Tsang K.W.T., Tipoe G.L., Sun J.Z., Mak J.C.W., Leung Y.H., Yan C.P.K., Ko K.W., Ooi C.G.C., Ho P.L., Ho J.C.M. and Lam W.K., Central microtubular ciliary defects are of clinical significance in bronchiectasis, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia. 2003, Abstract Book PP6-20: p.199.

Tsang K.W.T., Tipoe G.L., Sun J.Z., Mak J.C.W., Leung Y.H., Yan C.P.K., Ko K.W., Ooi C.G.C., Ho P.L., Ho J.C.M. and Lam W.K., Ciliary central microtubular orientation is of no clinical significance in bronchiectasis, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia. 2003, Abstract Book PP6-21: p.200.

Tsang K.W.T., Tipoe G.L., Sun J.Z., Mak J.C.W., Leung Y.H., Yan C.P.K., Ko K.W., Ooi C.G.C. and Lam W.K., Clinical significance of ciliary abnormalities in bronchiectasis, European Respiratory Journal. 2003, suppl 22(45): P559.

Tsang K.W.T., Ho P.L., Tan K.C., Ooi C.G.C., Ho J.C.M., Tipoe G.L., Lam W.K. and Chan M.M.W., Efficacy of 12-month treatment with inhaled corticosteroid in bronchiectasis, European Respiratory Journal. 2003, suppl 22(45): P3213.

Tsang K.W.T., Tipoe G.L., Sun J.Z., Leung Y.H., Ho P.L., Yuen K.Y., Mak J.C.W. and Lam W.K., Helicobacter pylori exotoxin disrupts ciliary beating and ultrastructure of human airway mucosa, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia. 2003, Abstract Book PP6-22: p.201.

Wong M.P., Tipoe G.L., Sun J.Z., Mak J.C.W., Ooi C.G.C., Ip M.S.M., Chan M.M.W., Lam W.K. and Tsang K.W.T., Clinical significance of ciliary abnormalities in bronchiectasis, Annual Scientific Meeting, Hong Kong Thoracic Society & American College of Chest Physicians, 2003. Abstract pp.30.

Wong W.M., Ho J.C.M., Hung I.F., Ng W., Lam Y.M., Tam W.O., Wong B.C.Y., Wong P.C., Lai C.L., Lam W.K., Lam S.K., Tsang K.W.T., Ooi C.G.C., Ho P.L., Mok T. and Chan J., Temporal Patterns of Hepatic Dysfunction and Disease Severity in Patients with SARS, Journal of the American Medical Association Southeast Asia (JAMA). 2003, 290(20): 2663-2665.

Wu A.Y.Y., Ooi C.G.C., Lam B., Mok T.Y.M., Ho P.L., Chan M.M.W., Ip M.S.M., Lam W.K. and Tsang K.W.T., The use of pentaglobin in patients with deteriorating severe acute respiratory syndrome, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia . 2003, Abstract Book PP6-15: p.194.

Zhu H., Wong M.P., Lam C.L., Cai W.W., Chau W.S., Wang E., Lam W.K., Chiu S.W. and Chung L.P., Genome-wide screening of chromosomal imbalance in NSCLC by array-based comparative genomic hybridization (array-CGH), Proceedings of the 95th Annual Meeting of American Association for Cancer Research, Orlando, Florida, USA, March 2004.

Researcher : Lam YM

List of Research Outputs

Ho J.C.M., Wong R.W.M., Ooi C.G.C., Mok T.Y., Hung I.F., Ng W., Lam Y.M., Tam W.O., Wong P.C., Ho P.L., Lai C.L., Lam W.K., Lam S.K. and Tsang K.W.T., Correlation of Liver Dysfunction And Disease Activity In Patients With Severe Acute Respiratory Syndrome, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-08.

Lau C.P., Lam Y.M., Lee K.L.F., Tse H.F., Siu D., Fan K. and Yung C., A rapid ultrasonic cardiac output monitor method for optimization of atrioventricular interval in cardiac resynchronization, Heart Rhythm 2004. 1: S279.

Wong W.M., Ho J.C.M., Hung I.F., Ng W., Lam Y.M., Tam W.O., Wong B.C.Y., Wong P.C., Lai C.L., Lam W.K., Lam S.K., Tsang K.W.T., Ooi C.G.C., Ho P.L., Mok T. and Chan J., Temporal Patterns of Hepatic Dysfunction and Disease Severity in Patients with SARS, Journal of the American Medical Association Southeast Asia (JAMA). 2003, 290(20): 2663-2665.

Researcher : Lan HY

List of Research Outputs

Wong L.Y.F., Cheung B.M.Y., Li Y.Y., Tang F. and Lan H.Y., Adrenomedullin suppresses migration inhibitory factor production and cytokine response of rat macrophages to lipopolysaccharide, Hong Kong Medical Journal. 2003, 9(1) Suppl: 29.

Researcher : Lau CP

Project Title:	Roles of macrophage migration inhibitory factor (MIF) in acute myocardial infarction
Investigator(s):	Prof. Lau C.P., Dr. Lan H.Y., Dr. Yu C.M.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2000

Abstract:

To investigate the pathogenic role and mechanism of macrophage migration inhibitory factor (MIF) after myocardial infarction (AMI).

Project Title:	Role of nitric oxide synthase and cyclooxygenase2 in angiogenesis after acute myocardial infarction - therapeutic implication by L-arginine
Investigator(s):	Prof. Lau C.P., Dr. Ho D.S.W., Mr. Lai K.W.H., Dr. Tipoe G.L., Dr. Tse H.F., Dr. Yu C.M.
Department:	Medicine
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	12/2000

Abstract:

Acute myocardial infarction (AMI) is the second commonest killer worldwide. The present study is to investigate the role of two cellular and molecular pathways that hypothesized to play a major role in angiogenesis in the heart muscles after AMI, namely the production of nitric oxide (NO) by its key enzyme nitric oxide synthase (NOS) and the synthesis of prostanoids by cyclooxygenase (COX).

List of Research Outputs

Barold S.S., Lau C.P., Tse H.F. and Hess M., Shortening of the Sensed AV Delay of a Dual Chamber Pacemaker During Normal Sinus Rhythm., J Interv Card Electrophysiol. 2003, 9: 29-34.

Chan C.C., Chan S.S.C., Lam T.H. and Lau C.P., A randomized controlled trial of a nurse delivered stage-matched smoking cessation intervention to promote heart health of cardiac patients, Book of Abstracts. 8th Postgraduate Symposium, Faculty of Medicine, University of Hong Kong. 2003.

Chan S.S.C., Lam T.H., Lau C.P. and Chan S.C.C., Characteristics of Chinese cardiac patients participated in a randomised controlled trial of a stage-matched smoking cessation intervention, Book of Abstracts. 12th World Conference on Tobacco or Health - Global action for a tobacco free future. Helsinki, Finland, 12th World Conference on Tobacco or Health Organizing Com, 2003, 110.

Chen W.H. and Lau C.P., Advances in antithrombin therapy for ST-elevation myocardiac infarction, Chin Med J (Engl)2003. 2003, 116(11): 1760-3. Review.

Chen W.H., Tse H.F., Lau C.P., Lee P.Y. and Ng W., Aspirin resistance is associated with a high incidence of myonecrosis after non-urgent percutaneous coronary intervention despite clopidogrel pretreatment, J Am Coll Cardiol . 2004, 43(6): 1122-6.

Chen W.H., Lau C.P., Lee P.Y. and Ng W., Percutaneous recanalization of chronic subclavian artery occlusion using optical coherence reflectometry-guided radiofrequency ablation guidewire, Catheter Cardiovasc Interv 2003 Dec. 2003, 60(4): 558-61.

Chen W.H., Lau C.P., Lee P.Y. and Ng W., Safety and feasibility of the use of a distal filter protection device in percutaneous revascularization of small coronary arteries, Catheter Cardiovasc Interv 2004. 2004, 61(3): 360-3.

Cheung B.M.Y., Lau C.P. and Kumana C.R., Combination therapy for hypertension, Hong Kong Medical Journal. 2003, 9: 224-6.

Cheung B.M.Y., Lo L.F., Chan S.K., Chan M.Y., Fong D.Y.T., Leung R.K.W., Wong S., Wong V., Lam K.S.L., Lau C.P., Lee P.W.H. and Karlberg J.P.E., Effect of qigong on hypertension: a randomised controlled study, Hong Kong Medical Journal. 2003, 9(1) Suppl: 21.

Cheung B.M.Y., Lam T.H., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Man Y.B., Cheng C.H., Kumana C.R. and Lau C.P., Follow Up of the Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort (CP17), Seventh Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine: Journal of the Hong Kong College of Cardiology . 2003, 11 (Suppl 1).

Cheung B.M.Y., Lam T.H., Lam K.S.L., Tam S.C.F., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Man Y.B., Cheng C.H., Kumana C.R. and Lau C.P., Follow up of the Hong Kong Cardiovascular risk factor prevalence survey cohort, Hong Kong Medical Journal. 2003, 9(1) Suppl: 27.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., High blood pressure is related to obesity in Hong Kong, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., High blood pressure is related to obesity in Hong Kong, Hong Kong Medical Journal. 2003, 9(1) Suppl: 35.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Lipid profile of the Hong Kong cardiovascular risk factor prevalence study cohort, Hong Kong Medical Journal. 2003, 9(1) Suppl: 22.

Cheung B.M.Y., Man Y.B., Lam K.S.L., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Lipid profile of the Hong Kong cardiovascular risk factor prevalence survey cohort, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Cheung B.M.Y., Lauder I.J., Lau C.P. and Kumana C.R., Meta-analysis of large randomized controlled trials to evaluate the impact of statins on cardiovascular outcomes, British Journal of Clinical Pharmacology. Blackwell Publishing, 2004, 57(5): 640-651.

Cheung B.M.Y. and Lau C.P., New opportunities and challenges in heart protection, Journal of Hong Kong College of Cardiology. 2003, 11: 1-3.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Obesity in the Hong Kong cardiovascular risk factor prevalence survey-2 (CRISPS2) cohort, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Cheung B.M.Y., Man Y.B., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of Diabetes Mellitus (DM) in the Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort (P16), Seventh Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine: Journal of the Hong Kong College of Cardiology . 2003, 11 (Suppl 1).

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of diabetes mellitus (DM) in the Hong Kong Cardiovascular risk factor prevalence study cohort, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Cheung B.M.Y., Man Y.B., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of diabetes mellitus (DM) in the Hong Kong Cardiovascular risk factor prevalence study cohort, Hong Kong Medical Journal. 2003, 9(1) Suppl: 19.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of obesity in the Hong Kong Cardiovascular risk factor prevalence survey-2 (CRISPS2), Hong Kong Medical Journal. 2003, 9(1) Suppl: 23.

Cheung B.M.Y., Law C.Y., Ho G.Y.Y., Ng P.P.Y., Kumana C.R. and Lau C.P., Randomised Controlled Trial of Low Salt Diet in the Treatment of Hypertension (P-229), In: FC Tuluney, M Orme, Sixth Congress of European Association of Clinical Pharmacology adn Therapeutics - European Collaboration: Towards Drug Development and Rational Drug Therapy. 2003, 132.

Cheung B.M.Y., Law C.Y., Fung P.C.W., Tsang K.W.T., Tan K.C.B., Kumana C.R. and Lau C.P., Randomised Trial of Candesartan and Enalapril (RACE) in the treatment of hypertension (P-215), In: FC Tuluney, M Orme, Sixth Congress of European Association of Clinical Pharmacology adn Therapeutics - European Collaboration: Towards Drug Development and Rational Drug Therapy . 2003, 128.

Cheung B.M.Y., Law C.Y., Ho G.Y.Y., Ng P.P.Y., Kumana C.R. and Lau C.P., Randomised controlled trial of low salt diet in the treatment of hypertension, Hong Kong Medical Journal. 2003, 9(1) Suppl: 23.

Cheung B.M.Y., Law C.Y., Fung P.C.W., Tsang K.W.T., Tan K.C.B., Kumana C.R. and Lau C.P., Randomised trial of candesartan and enalapril (RACE) in the treatment of hypertension-final results, Hong Kong Medical Journal. 2003, 9(1) Suppl: 24.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Relationship between Hypertension and Obesity in Hong Kong, 3rd Asian-Pacific Congress of Hypertension. 2004.

Cheung B.M.Y., Leung Y.H., Wong L.Y.F., Man Y.B., Lau C.P. and Kumana C.R., Urotensin II in hypertension, Hong Kong Medical Journal. 2003, 9(1) Suppl: 24.

Du X., Gao Z., Lau C.P., Chiu S.W., Tse H.F., Baumgarten C.M. and Li G.R., Differential effects of tyrosine kinase inhibitors on volume-sensitive chloride current in human atrial myocytes: evidence for dual regulation by Src and EGFR kinases, Journal of General Physiology. 2004, 123: 427-39.

Gao Z., Lau C.P., Chiu S.W. and Li G.R., A novel ionic mechanism of verapamil in human atrial myocytes, Biophysical Journal/48th Biophysical Society, Baltimore, MD, USA. 2004, 86: 719.

Gao Z., Lau C.P., Chiu S.W. and Li G.R., Effects of Verapamil on Transient Outward and Ultra-rapid Delayed Rectifier Potassium Current in Human Atrial Myocytes , Journal of the Hong Kong College of Cardiology/The 7th Annual Meeting, Institute of Cardiovascular Science and Medicine. 2003, 11 (suppl 1): A14.

Gao Z., Lau C.P., Chiu S.W. and Li G.R., Inhibition of ultra-rapid delayed rectifier K+ current by verapamil in human atrial myocytes, Journal of Molecular and Cellular Cardiology . 2004, 36: 257-263.

Gao Z., Lau C.P., Wong T.M. and Li G.R., Protein tyrosine kinase-dependent modulation of voltage-dependent potassium channels by genistein in rat cardiac ventricular myocytes, Cellular Signaling. 2004, 16: 333-341.

Ho H.H., Lee K.L.F., Lau C.P. and Tse H.F., Clinical characteristics of and long-term outcome in Chinese patients with hypertrophic cardiomyopathy , American Journal of Medicine. 2004, 116(1): 19-23.

Kwok K.M., Lee K.L.F., Lau C.P. and Tse H.F., Sudden cardiac death: prevention and treatment , Hong Kong Medical Journal. 2003, 9(5): 357-62.

Lam T.C., Cheung B.M.Y., Ko B.C.K., Chung S.S.M. and Lau C.P., Genetic linkage of beta and gamma subunits of epithelial sodium channel to systolic blood pressure in southern Chinese, Hong Kong Medical Journal. 2003, 9(1) Suppl: 25.

Lau C.P., Lam Y.M., Lee K.L.F., Tse H.F., Siu D., Fan K. and Yung C., A rapid ultrasonic cardiac output monitor method for optimization of atrioventricular interval in cardiac resynchronization, Heart Rhythm 2004. 1: S279.

Lau C.P., Tse H.F., Lee K.L.F., Barold S., Chan H.W., Fan K., Chau E. and Yu C.M., Advances in devices for cardiac resynchronization in heart failure., Journal of Cardiovascular Electrophysiology. 2003, 9(2): 167-81.

Lau C.P., Tse H.F., Lee K.L.F. and Barold S.S., Unusual indication for cardiac pacing. Barold SS, Mugica J(eds). , In: The Fifth Decade of Cardiac Pacing. Armonk NY. Futura Publishing Co, Inc, 2004, 2004: 32-43.

Li G.R., Sun H., To J.Y.T., Tse H.F. and Lau C.P., Demonstration of calcium-activated transient outward chloride current and delayed rectifier potassium currents in Swine atrial myocytes, Journal of Molecular and Cellular Cardiology . 2004, 36: 495-504.

Man Y.B., Cheung B.M.Y., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of hypertension in the Hong Kong cardiovascular risk factor prevalence study cohort, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Ng W., Chen W.H., Lee P.Y. and Lau C.P., Initial experience and safety in the treatment of chronic total coronary occlusions with a new optical coherent reflectometry-guided radiofreqency ablation guideline., Am J Cardiol.. 2003, 92 (6): 732-4.

Siu C.W., Lau C.P. and Tse H.F., Prevention of atrial fibrillation recurrence by statin therapy in patients with lone atrial fibrillation after successful cardioversion, American Journal of Cardiology. 2003, 92(11): 1343-5.

Tse H.F., Lau C.P. and Lee P.Y., Bone Marrow Cell Transplantation for Myocardial Regeneration and Therapeutic Angiogenesis, In: Angiogenesis and Direct Myocardial Revascularization. Totowa, NJ: Human Press Inc, 2004(in press). Humana Press Inc, 2004, 2004.

Tse H.F. and Lau C.P., Clinical Predictors and Time Course of Arrhythmia Recurrence in Patients with Early Reinitiation of Atrial Fibrillation After Successful Internal Cardioversion., Pacing Clin Electrophysiol.. 2003, 26 (9): 1809-1814.

Tse H.F., Siu C...W..., Ripley K...L. and Lau C.P., Determinants of lesion dimension during catheter cryoablation: effects of tip electrode temperature and size, Heart Rhythm 2004. 1: S111.

Tse H.F. and Lau C.P., Does sinus rhythm beget sinus rhythm? Effects of prompt cardioversion the frequency and persistence of recurrent atrial fibrillation, Cardiac Electrophysiology Review. 2003, 7(4): 359-65.

Tse H.F., Yu K.M.C., Paul V.E., Boriani G., Schuchert A., Del Ojo J.L., Malinowski K., Blanc J.J. and Lau C.P., Effect of left ventricular function on long-term left ventricular pacing and sensing threshold., J Interv Card Electrophysiol. 2003, 9 (1): 21-4.

Tse H.F. and Lau C.P., Future prospects for implantable devices for atrial defibrillation, Cardiology Clinics. 2004, 22(1): 87-100.

Tse H.F., Thambar S., Kwong Y.L., Chen W.H., Lau C.P., Chan J.K.F., Lo G., Lai C.L. and Bellan G., Long-Term clinical outcome of catheter-based intramyocardial autologous bone marrow cells implanation in patients with end-stage coronary artery disease, J Am Coll Cardiol. 2004, 43: 39A.

Tse H.F., Reek S., Timmermans C., Lee K.L.F., Geller J.C., Rodriguez L.M., Ghaye B., Ayers G.M., Crijns H.J., Klein H.U. and Lau C.P., Pulmonary vein isolation using transvenous catheter cryoablation for treatment of atrial fibrillation without risk of pulmonary vein stenosis., J Am Coll Cardiol.. 2003, 42 (4): 752-8.

Tse H.F. and Lau C.P., Recurrence of atrial fibrillation after pulmonary vein isolation., J Cardiovasc Electrophysiol.. 2003, 14 (7): 691-2.

Tse H.F. and Lau C.P., Reply to the Editor, Journal of Cardiovascular Electrophysiology. 2003, 14(8): 899 -900.

Tse H.F., Kwong Y.L., Chan J.K.F., Lo R., Ho C.L., Yeung D.W. and Lau C.P., Therapeutic angiogenesis of human ischemic myocardium by catheter-based intramyocardial autologous bone marrow cell implantation, Lancet. 2003, 361: 47-9.

Wang X., Fielding R., Lau C.P., Leung K.K., Shi Q.J. and Li X.Q., Depression in Chinese CAD patients validation of Chinese version of BDI-II and HADS, 8th Research Postgraduate Symposium, The University of Hong Kong, 13 December 2003, Hong Kong (Abstract). 2003, 85.

Xu W...C..., Tse H.F., Chan F.H.Y., Fung P.C.W. and Lau C.P., U.S. Patent, "A bayesian discriminator for rapidly detecting arrhythmias", 2003.

Researcher : Lau GKK

Project Title:	Hepatitis B virus specific T cell determinants of liver damages during the immuneclearance phase of chronic HBV infection
Investigator(s):	Dr. Lau G.K.K., Dr. He M.L.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	10/2002
Completion Date:	09/2003

Abstract:

To study the T cell determinants of liver damages during the immune-clearance phase of chronic HBV infection

Project Title:	Role of intrahepatic close-circular covalent (ccc) DNA in HBV reactivation in hepatitis B surface antigen positive subjects who received chemotherapy
Investigator(s):	Dr. Lau G.K.K., Dr. He M.L., Prof. Liang R.H.S.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2002

Abstract:

To study the T cell determinants of liver damages during the immune-clearance phase of chronic HBV infection.

Project Title:	Characterization of the HBV-specific cytotoxic T lymphocyte (CTL) activities associated with a sustained remission after anti-HBV therapy in Chinese with chronic HBV infection
Investigator(s):	Dr. Lau G.K.K., Dr. Lin C.L., Dr. Zhang H.Y.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	02/2004

Abstract:

To compare the frequency and phenotype of the end-of-therapy virus-specific CD8+ T cells in chronic HBV patients who had sustained response to anti-HBV therapy with those who relapse; to compare the characteristics of end-of-therapy HBV-specific CD8+ T cells in those who were treated with nucleoside analogues, such as lamivudine, and those treated with immune therapy, such as pegylated interferon.

List of Research Outputs

Au W.Y., Lie A.K.W., Ma E.S.K., Lau G., Chan C. and Kwong Y.L., Late onset pure red cell aplasia due to delayed lymphoid engraftment complicating ABO mismatched hematopoietic stem cell transplantaion, Transfusion. 2004, 44: 946-947.

Cheng V.C., Lo C.M. and Lau G., Current issues and treatment of fulminant hepatic failure including transplantation in Hong Kong and the Far East, Seminars in Liver Disease. 2003, 23(3): 239-250.

Chow L.W.C. and Lau G., Preoperative chemotherapy for breast cancer based on chemosensitivity assay, Asian Breast Cancer Conference, Taipei, Taiwan, February 2004.

Lau G., Werle B., Wursthorn K. and Pertersen J., EASL Jury, EASL International Consensus Conference on Hepatitis , Journal of Hepatology. 2003, 38(4): 533-540.

Lau G., Yiu H.H.Y., Fong D.Y.T., Cheng H.C., Au W.Y., Lai L.S.F., Cheung M., Zhang H.Y., Lie A.K.W., Ngan K.C. and Liang R.H.S., Early Is Superior to Deferred Preemptive Lamivudine Therapy for Hepatitis B Patients Undergoing Chemotherapy, Gastroenterology. 2003, 125: 1742-1749.

Lau G., 新藥聚乙二醇干擾素乙型肝炎病者新希望, METRO DAILY. 2004, 23.

Lau G., New hepatitis B vaccine launched , The Standard . 2003, B2 .

Lau G., Zhang H.Y., Luk J.M.C., Locarnini S. and Liang R.H.S., Pre-emptive use of lamivudine reduces hepatitis B exacerbation after allogeneic hematopoietic cell transplantation, Hepatology. 2004, 39: 867-868.

Lau G., Lie A.K.W. and Liang R.H.S., Preemptive lamivudine in hepatitis B patients undergoing chemotherapy, Gastroenterology. 2004, 126(7): 1924-5.

Lau G., 港大研乙肝新藥治癒率增四倍 , 經濟日報 , 2003, A25 .

Lau G., 服半年可停藥乙肝新藥副作用少 , 星島日報 , 2003, A10 .

Lau G., 丙肝藥物可治乙肝 , 東方日報 , 2003, A16 .

Lau G., 粵公布防炎新藥方案 , 東方日報 , 2003.

Lau G., 港引入第三代乙肝疫苗 , 東方日報 , 2003, A11 .

Lo C.M., Cheung S.T., Lau G., Yuen M.F., Liu C.L., Fan S.T. and Wong J., Significance of hepatitis B virus genotype in liver transplantation for chronic hepatitis B (Invited Lecture), Digestive Disease Week, New Orleans, U.S.A., 15-20 May 2004.

Lo C.M., Cheung S.T., Lau G., Yuen M.F., Liu C.L., Fan S.T. and Wong J., Significance of hepatitis B virus genotype in liver transplantation for chronic hepatitis B (Invited Lecture), The 5th Joint Annual Meeting of the American Society of Transplant Surgeons and the American Society of Transplantation, Boston, U.S.A., 14-19 May 2004.

Luo Y., Lo C.M., Cheung C.K.Y., Lau G., Fan S.T. and Wong J., Hepatitis B virus (HBV)-specific immune response after liver transplantation for chronic hepatitis B (Abstract), Liver Transplantation. 2004, 10(6): C42.

Luo Y., Lo C.M., Cheung C.K.Y., Lau G., Fan S.T. and Wong J., Identification of hepatitis B virus (HBV)-specific lymphocytes in human liver allografts from HBV immune donors (Abstract), The 5th Joint Annual Meeting of the American Society of Transplant Surgeons and the American Society of Transplantation, Boston, U.S.A., 15-19 May 2004.

Ma E.S.K., Au W.Y., Lie A.K.W., Ng I.O.L., Leung A.Y.H., Tse E.W.C., Liang R.H.S., Lau G. and Kwong Y.L., Liver graft-versus-host disease after donor lymphocyte infusion for relapses of hematologic malignancies post allogeneic hematopoietic stem cell transplantation, Bone Marrow Transplantation. 2004, 34: 57-61.

Ma S.Y., Au W.Y., Ng I.O.L., Lie A.K.W., Liang R.H.S., Lau G. and Kwong Y.L., Hepatitic graft-versus-host disease after hematopoietic stem cell transplantation : clinicopathologic features and prognostic implication, Transplantation. 2004, 77: 1252-1259.

Ma S.Y., Lau G., Cheng V.C.C. and Liang R.H.S., Hepatitis B reactivation in patients positive for hepatitis B surface antigen undergoing autologous hematopoietic cell transplantation, Leukemia and Lymphoma. 2003, 44(8): 1281-5.

Ma S.Y., Au W.Y., Ng I.O.L., Lie A.K., Leung A.Y., Liang R.H.S., Lau G. and Kwong Y.L., Role of liver biopsy in the management of liver dysfunction after hematopoietic stem-cell transplantation in a hepatitis B virus-prevalent patient population, Transplantation. 2003, 7691): 169-176.

Werle B., Wursthorn K., Pertersen J., Boweden S., Locarnini S., Lau G., Trepo C., James C., Brosgart C., Delaney W., Gibbs C. and Zoulim F., Reductions in Serum Hepatitis B Surface Antigen (HBsAg) Occur in Parallel with Reductions in Intrahepatic HBV Covalently Closed Circular (ccc) DNA in Chronic Hepatitis B (CH-B) Patients Receiving Adefovir Dipivoxil (ADV). , Gastroenterology. 2004, 126: 1750-8.

Researcher : Lau HL

List of Research Outputs

Kung A.W.C., Ng M.Y.M., Lau H.L., Paterson A.D., Bulman D., Luk K.D.K. and Chan V.N.Y., Association of low bone mineral density to microsatellite marker on chromosome 16 in Southern Chinese families, 4th International Meeting on the Genetic Epidemiology of complex Traits, 4-7 April 2004, Churchill College, Cambridge, UK. 2004.

Lau H.L., Ho A.Y.Y., Luk K.D.K. and Kung A.W.C., Association of 12 genetic loci and environmental risk factors with bone mineral density in Chinese, 2nd Asian Regional International Osteoporosis Foundation Conference on Osteoporosis, 16-18 January 2004, Hong Kong . 2004.

Lau H.L., Ho A.Y.Y., Luk K.D.K. and Kung A.W.C., Genetic and envorinmental determinants of bone mineral density in Chinese women, 25th Annual Meeting of the American Society for Bone and Mineral Research, 19-23 September 2003, Minnesota, USA. Journal of Bone and Mineral Research . 2003, 18(Suppl 2): M126.

Lau H.L., Ho A.Y.Y., Luk K.D.K. and Kung A.W.C., Site and age specificity of genetic and environmental determinants of bone mineral density, 8th Research Postgraduate Symposium organised by the Faculty of Medicine, The University of Hong Kong, Hong Kong, December 13, 2003.

Lau H.L., Paterson A., Luk K.D.K. and Kung A.W.C., Test of linkage and/or association of genes and bone mineral density in Chinese, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.. 2004.

Lau H.L., Ho A.Y.Y., Luk K.D.K. and Kung A.W.C., Transforming growth factor-b1 gene polymorphisms and bone turnover, bone mineral density and fracture risk in Southern Chinese women , Calcified Tissue International. 2004, online.

Researcher : Lau KCJ

List of Research Outputs

Lau K.C.J., Fraser R...C. and Lam C.L.K., Establishing the content validity in Hong Kong of the prioritized criteria of consultation competence in the Leicester Assessment Package (LAP), Hong Kong Practitioner. Hong Kong, 2003, 25 (12): 596-602.

Researcher : Lau KS

List of Research Outputs

Kung A.W.C., Lau K.S. and Chan V.N.Y., Association of a novel single nucleotide polymorphism in the calcium channel a subunit gene (Cav1.1) and thyrotoxic periodic paralysis, Journal of Clinical Endocrinology & Metabolism. 2004, 89(3): 1340-5.

Kung A.W.C., Lau K.S., Fong C.Y. and Chan V.N.Y., Association of novel single-nucleotide polymorphisms in the dihydropyridine sensitive L-type a-3 calcium channel (CACNL1a3) and thyrotoxic periodic paralysis (TPP) , American thyroid Association 75th Annual Meeting, 16-21 September 2003, Palm Beach, USA. Thyroid. 2003, 13(7): 672.

Researcher : Lau WCS

Project Title:	Effects of sex hormones on lymphocyte function in systemic lupus erythematosus
Investigator(s):	Prof. Lau W.C.S., Dr. Mok T.M.Y.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2002

Abstract:

To examine the effects of estrogen, testrogen, testosterone and prolactin on SLE peripheral T- and B-lymphocyte apoptosis and function. Menstruating and postmenopausal female patients and male patients will be studied.

Project Title:	A study to evaluate the immunopathology of Severe Acute Respiratory Syndrome
Investigator(s):	Prof. Lau W.C.S., Dr. Chan E.Y.T., Dr. Cheung B.M.Y.
Department:	Medicine
Source(s) of Funding:	SARS Research Fund
Start Date:	07/2003

Abstract:

To investigate the time course of changes in cytokines in patients with SARS; to investigate the relationship between clinical deterioration and changes in the serum/plasma levels of cytokines; to evaluate the cytokine expression in post-mortem lung tissues of patients with SARS will be studied.

Project Title:	Osteopontin and rheumatoid arthritis
Investigator(s):	Prof. Lau W.C.S., Dr. Chiu P.K.Y., Prof. Fung P.C.W., Dr. Tang W.M., Dr. Tsang K.W.T.
Department:	Medicine
Source(s) of Funding:	RGC Projects (Block Grant Funded)
Start Date:	07/2003

Abstract:

To confirm that OPN expression is increased in rheumatoid synovium; to determine if T cell activation is associated with increased OPN synthesis; to study the effects of macrophage derived cytokines and IL-10, an anti-inflammatory cytokine, on synovial cell OPN expression; to evaluate the effects of OPN on rheumatoid synovial cell function, including free radical production, cytokine production and MMP expression.

Project Title:	Evaluation of the effects of sex hormones on neutrophils and macrophage apoptosis and macrophage phagocytic clearance of apoptotic neutrophils in systemic lupus erythematosus
Investigator(s):	Prof. Lau W.C.S.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2003

Abstract:

To study the effects of oestrogen and progesterone on the rate of apoptosis and secondary necrosis of PMN and Mf in SLE patients and controls; to study the effects of oestrogen and progesterone on the ability of phagocytic Mf to clear apoptotic bodies in patients with SLE and controls.

List of Research Outputs

Cheung G.T.Y., Lau W.C.S. and Kumana C.R., Phosphodiesterase-5 inhibitors relieve symptoms of severe Raynaud's phenomenon, The European League Against Rheumatism (EULAR) Annual Congress for Rheumatology, Berlin, Germany. 2004.

Chong W.P., Ip E.W.K., Lau W.C.S., Chan D.T.M., Padyukov L. and Lau Y.L., Common NOD2 polymorphisms in Hong Kong Chinese patients with systemic lupus erythematosus, Rheumatology. 2004, 43: 104-105.

Chu E.M., Chiu P.K.Y., Wong R.W., Tang W.M. and Lau W.C.S., Translation and validation of arthritis impact measurement scales 2 into Chinese: CAIMS2, Arthritis and Rheumatism (Arthritis Care & Research). 2004, 51: 20-27.

Ho J.C.M., Tipoe G.L., Zheng L., Leung T.M., Tsang K.W.T., Shum D.K.Y., Lau W.C.S., Mak J.C.W., Lam W.K. and Ip M.S.M., In vitro study of regulation of IL-6 production in bronchiectasis, Respiratory Medicine. 2004, 98: 334-341.

Ho Y.W., Man R.Y.K. and Lau W.C.S., Effects of ganoderm lucidium (Lingzhi) on proliferation and cytokine production of synovial fibroblasts from rheumatoid arthritis patients, Annals of the Rheumatic Diseases, The EULAR Journal. 2003, 62(suppl I): 409.

Jin O., Tan K.C., Yeung J.S.L., Tam S.C.F. and Lau W.C.S., Influence on hyperlipidaemia on macrophage phagocytosis of apoptotic cells, 7th International Congress on SLE & Related Conditions, New York. 2004.

Jin O., Sun L.Y., Zhou K.X., Zhang X.S., Feng X.B., Mok T.M.Y. and Lau W.C.S., Lymphocyte apoptosis and macrophage function correlation with disease activity in systemic lupus erythematosus, 7th International Congress on SLE & Related Conditions, New York. 2004.

Jin O., Sun L., Zhou K., Zhan X., Mok T.M.Y. and Lau W.C.S., Lymphocyte apoptosis, macrophage function and disease activity in systemic lupus erythematosus, Annals of the Rheumatic Diseaes, The EULAR Journal. 2003, 62(suppl I): 198.

Jin O., Chan W.K., Mok T.M.Y., Sun L.Y. and Lau W.C.S., Serum levels of osteopontin and matrix metalloproteinase-3 in systemic lupus erythematosus (SLE), 7th International Congress on SLE & Related Conditions, New York. 2004.

Kong E.K.P., Prokunina L., Chan D.T.M., Lau W.C.S., Alarcon-Riquelme M.E. and Lau Y.L., Analysis of a new potentially regulatory polymorphism in the PDCD1 gene in systemic lupus erythematosus, Human Genome Meeting. 2004, Poster Number 92.

Kong K.P., Chan T.M., Lau W.C.S. and Lau Y.L., Association of PDCD1 polymorphisms with systemic lupus erythematosus, 8^th Research Postgraduate Symposium, Hong Kong, 13 December 2003. 73.

Kumar S., Lau W.C.S., Chan W.K., Yang D., Cheung H.Y., Chen F. and Hyde K.D., Immunomodulatory activity of an endophytic fungus isolated from Tripterygium wilfordii, 2nd International Conference on Medicinal Mushroom and the International Conference on Biodiversity and Bioactive Compounds. 2003, 367-373.

Lau W.C.S., An overview of the pathogenesis and treatment of pulmonary hypertension: Part 1, Hong Kong Bulletin on Rheumatic Diseases. 2004, 4(1): 19-25.

Lau W.C.S., Approach to Connective Tissue Diseases, Hong Kong Doctors' Union CME Programme. 2003.

Lau W.C.S., Current status in the medical treatment of osteoarthritis, The First Hong Kong International Orthopaedic Forum, Hong Kong. 2004.

Lau W.C.S., Diagnosis and Early Treatment of Common Arthritis, Solar-Med Limited and Genzyme Corporation Limited. 2003.

Lau W.C.S. and Kumar S., Immunomodulatory Activity of an Endophytic Fungus from Tripterygium Wilfordii, a Chinese Medical Plant, Marine Biotechnology Conference. 2003, 8010.

Lau W.C.S., International Perspective and HKU - Assessment: UK Perspective Similarities and Differences with the HKU Cirricumlum, Frontiers in Biomedical Research, The University of Hong Kong. 2003.

Lau W.C.S., Logical Emergencies, 16th Annual Scientific Meeting, Hong Kong Society of Rheumatology. 2003.

Lau W.C.S., Management of systemic lupus erythematosus, Hong Kong Doctors' Union, Semi-Annual CME Bulletin. 2004.

Lau W.C.S. and Lau W.C.S., Novel Therapies for Osteoarthritis, Hong Kong Medical Forum. 2003.

Lau W.C.S., Rheumatic Disease and the Eye, Annual Scientific Meeting, Hong Kong Ophthalmological Symposium 2003.

Lau W.C.S., The usefulness of autoantibody tests in the diagnosis and management of systemic lupus erythematosus, Hong Kong Doctors' Union, Semi-Annual CME Bulletin. 2004.

Lau W.C.S., Treatment of difficult lupus nephritis, 9th Annual Scientific Meeting, Chinese Rheuamtology Association, Chengdu, China. 2003.

Lau W.C.S., Treatment of difficult lupus nephritis, In: CS Lau, 9th Annual Scientific Meeting, Chinese Rheumatology Association. 2003.

Lau W.C.S., Treatment of knee osteoarthritis (OA) with Lyprinol(R), lipid extract of the green-lipped mussel - a double-blind placebo-controlled study, 9th Medical Research Conference, Hong Kong. 2004.

Lau W.C.S., Who's afraid of the big bad wolf? Fifth Tay Chong Hai Lecture of the National Arthritis Foundation of Singapore, APLAR Journal of Rheumatology. 2004, 7: 83-89.

Lau Y.L., Ip E.W.K., Chong W.P., Kong K.P., Chan T.M. and Lau W.C.S., Genetics of SLE, The 11th Asian Congress of Pediatrics & The 1st Asian Congress on Pediatric Nursing, Bangkok, Thailand, 2-7 November 2003.

Lee K.K. and Lau W.C.S., Early diagnosis and treatment of rheumatoid arthritis, Hong Kong Doctors' Union Bulletins on Self Study CME Series. 2003.

Mok C.C., Ying S.K.Y., Lau W.C.S., Yim C.W., Ng W.L., Wong R.W.S. and Au T.C., An open-label study of combined prednisone and azathioprine in the treatment of pure membranous lupus nephropathy, 7th International Congress on SLE and Related Conditions, New York. 2004.

Mok C.C. and Lau W.C.S., Pathogenesis of systemic lupus erythematosus, Journal of Clinical Pathology. 2003, 481-490.

Mok C.C., Ying S.K.Y., Tang S.S.K., Leung C.Y., Lee K.W., Ng W.L., Wong R.W.S. and Lau W.C.S., Predictors and outcome of renal flares after successful cyclophosphamide treatment for diffuse proliferative lupus glomerulonephritis, The European League Against Rheumatism (EULAR) Annual Congress for Rheumatology, Berlin, Germany. 2004.

Mok T.M.Y., Yeung J.S.L., Jin O., Chan W.K., Lo Y. and Lau W.C.S., Anti-beta2 glycoprotein I antibodies facilitates phagocytosis of apoptotic neutrophils in patients with systemic lupus erythematosus, The Hong Kong Practitioner. 2003, 9(Suppl 1): 65.

Mok T.M.Y., Chan E.Y.T., Leung K., Lo Y., Wong R.W.S. and Lau W.C.S., Antiphospholipid antibody profiles in Chinese patients with systemic lupus erythematosus, The Hong Kong Practitioner. 2004, 2: RI-04.

Mok T.M.Y., Lao T.T.H., Collins R.J., Leung T.Y., Leung P.Y., Chan D.T.M., Wong R.W.S. and Lau W.C.S., Cervical dysplasia in patients with systemic lupus erythematosus, 7th International Congress on SLE and Related Condidtions, New York. 2004.

Mok T.M.Y., Lao T.T.H., Collins R.J., Leung T.Y., Leung P.Y., Lo Y., Chan D.T.M., Wong R.W.S. and Lau W.C.S., Cervical dysplasia in patients with systemic lupus erythematosus, The Hong Kong Practitioner. 2004, 2: RI-05.

Mok T.M.Y., Leung P.Y., Lao T.T.H., Lo Y., Chan D.T.M., Wong R.W.S. and Lau W.C.S., Clinical predictors of fetal and maternal outcome in Chinese patients with systemic lupus erythematosus, 7th International Congress on SLE and Related Conditions, New York. 2004.

Mok T.M.Y., Leung P.Y., Lao T.T.H., Chan D.T.M., Wong R.W.S. and Lau W.C.S., Clinical predictors of fetal and maternal outcome in Chinese patients with systemic lupus erythematosus, The Hong Kong Practitioner. 2004, 2: RI-053.

Mok T.M.Y., Lo Y., Chan D.T.M., Wong R.W.S. and Lau W.C.S., Efficacy of chemotherapy for tuberculosis infection in patients with systemic lupus erythematosus in an endemic area, The Hong Kong Practitioner. 2003, 9(Suppl 1): 65.

Mok T.M.Y., Yeung J.S.L., Chan W.K., Leung P.Y., Lo Y. and Lau W.C.S., Sex hormones and apoptosis and immunoglobulin production in systemic lupus erythematosus, The Hong Kong Practitioner. 2003, 9(Suppl 1): 66.

Ren Y., Tang J., Mok T.M.Y., Chan A.W., Wu A.Y.Y. and Lau W.C.S., Increased apoptotic blood neutrophils and macrophages and decreased clearance of apoptotic neutrophils in systemic lupus erythematosus, Arthritis & Rheumatism. 2003, 48(10): 2888 - 2897.

Ren Y., Tang J.L., Mok T.M.Y., Chan W.K., Wu A.Y.Y. and Lau W.C.S., Increased apoptotic neutrophils and macrophages and impaired macrophage phagocytic clearance of apoptotic neutrophils in systemic lupus erythematosus, Arthritis & Rheumatism. 2003, 48: 2888-97.

Sun L.Y., Gu N.Y., Jin O. and Lau W.C.S., Biological characteristics and hematopoietic cytokine expression of human bone marrow-derived mesenchymal stem cells in systemic lupus erythematosus, 7th International Congress on SLE & Related Condition, New York. 2004.

Woo J., Lau E., Lau W.C.S., Lee P., Zhang J., Kwok T., Chan C., Chiu P., Chan K.M., Chan A. and Lam D., Socioeconomic impact of osteoarthritis in Hong Kong: Utilisation of health and social services, and direct and indirect costs, Arthritis & Rheumatism (Arthritis Care & Research). 2003, 49(4): 526-534.

Researcher : Law CY

List of Research Outputs

Cheung B.M.Y., Lam T.H., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Man Y.B., Cheng C.H., Kumana C.R. and Lau C.P., Follow Up of the Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort (CP17), Seventh Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine: Journal of the Hong Kong College of Cardiology . 2003, 11 (Suppl 1).

Cheung B.M.Y., Lam T.H., Lam K.S.L., Tam S.C.F., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Man Y.B., Cheng C.H., Kumana C.R. and Lau C.P., Follow up of the Hong Kong Cardiovascular risk factor prevalence survey cohort, Hong Kong Medical Journal. 2003, 9(1) Suppl: 27.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., High blood pressure is related to obesity in Hong Kong, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., High blood pressure is related to obesity in Hong Kong, Hong Kong Medical Journal. 2003, 9(1) Suppl: 35.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Lipid profile of the Hong Kong cardiovascular risk factor prevalence study cohort, Hong Kong Medical Journal. 2003, 9(1) Suppl: 22.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Obesity in the Hong Kong cardiovascular risk factor prevalence survey-2 (CRISPS2) cohort, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Cheung B.M.Y., Man Y.B., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of Diabetes Mellitus (DM) in the Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort (P16), Seventh Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine: Journal of the Hong Kong College of Cardiology . 2003, 11 (Suppl 1).

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of diabetes mellitus (DM) in the Hong Kong Cardiovascular risk factor prevalence study cohort, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Cheung B.M.Y., Man Y.B., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of diabetes mellitus (DM) in the Hong Kong Cardiovascular risk factor prevalence study cohort, Hong Kong Medical Journal. 2003, 9(1) Suppl: 19.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of obesity in the Hong Kong Cardiovascular risk factor prevalence survey-2 (CRISPS2), Hong Kong Medical Journal. 2003, 9(1) Suppl: 23.

Cheung B.M.Y., Law C.Y., Ho G.Y.Y., Ng P.P.Y., Kumana C.R. and Lau C.P., Randomised Controlled Trial of Low Salt Diet in the Treatment of Hypertension (P-229), In: FC Tuluney, M Orme, Sixth Congress of European Association of Clinical Pharmacology adn Therapeutics - European Collaboration: Towards Drug Development and Rational Drug Therapy. 2003, 132.

Cheung B.M.Y., Law C.Y., Fung P.C.W., Tsang K.W.T., Tan K.C.B., Kumana C.R. and Lau C.P., Randomised Trial of Candesartan and Enalapril (RACE) in the treatment of hypertension (P-215), In: FC Tuluney, M Orme, Sixth Congress of European Association of Clinical Pharmacology adn Therapeutics - European Collaboration: Towards Drug Development and Rational Drug Therapy . 2003, 128.

Cheung B.M.Y., Law C.Y., Ho G.Y.Y., Ng P.P.Y., Kumana C.R. and Lau C.P., Randomised controlled trial of low salt diet in the treatment of hypertension, Hong Kong Medical Journal. 2003, 9(1) Suppl: 23.

Cheung B.M.Y., Law C.Y., Fung P.C.W., Tsang K.W.T., Tan K.C.B., Kumana C.R. and Lau C.P., Randomised trial of candesartan and enalapril (RACE) in the treatment of hypertension-final results, Hong Kong Medical Journal. 2003, 9(1) Suppl: 24.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Relationship between Hypertension and Obesity in Hong Kong, 3rd Asian-Pacific Congress of Hypertension. 2004.

Man Y.B., Cheung B.M.Y., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of hypertension in the Hong Kong cardiovascular risk factor prevalence study cohort, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Researcher : Lee KLF

List of Research Outputs

Ho H.H., Lee K.L.F., Lau C.P. and Tse H.F., Clinical characteristics of and long-term outcome in Chinese patients with hypertrophic cardiomyopathy , American Journal of Medicine. 2004, 116(1): 19-23.

Kwok K.M., Lee K.L.F., Lau C.P. and Tse H.F., Sudden cardiac death: prevention and treatment , Hong Kong Medical Journal. 2003, 9(5): 357-62.

Lau C.P., Lam Y.M., Lee K.L.F., Tse H.F., Siu D., Fan K. and Yung C., A rapid ultrasonic cardiac output monitor method for optimization of atrioventricular interval in cardiac resynchronization, Heart Rhythm 2004. 1: S279.

Lau C.P., Tse H.F., Lee K.L.F., Barold S., Chan H.W., Fan K., Chau E. and Yu C.M., Advances in devices for cardiac resynchronization in heart failure., Journal of Cardiovascular Electrophysiology. 2003, 9(2): 167-81.

Lau C.P., Tse H.F., Lee K.L.F. and Barold S.S., Unusual indication for cardiac pacing. Barold SS, Mugica J(eds). , In: The Fifth Decade of Cardiac Pacing. Armonk NY. Futura Publishing Co, Inc, 2004, 2004: 32-43.

Tse H.F., Lee K.L.F., Wan S.H., Yu Y., Walter H., Pastore J., Pastore J., Zhu Q., Kenknight B. and Spinella J., Area of left ventricualr regional conduction delay and preserved contractility predict response to cardiac resynchronization therapy, J am Coll Cardiol 2004. 43: 130A.

Tse H.F., Reek S., Timmermans C., Lee K.L.F., Geller J.C., Rodriguez L.M., Ghaye B., Ayers G.M., Crijns H.J., Klein H.U. and Lau C.P., Pulmonary vein isolation using transvenous catheter cryoablation for treatment of atrial fibrillation without risk of pulmonary vein stenosis., J Am Coll Cardiol.. 2003, 42 (4): 752-8.

Researcher : Lee WS

List of Research Outputs

Shen J., Lee W.S. and Fung P.C.W., Cellular cholesterol ester accumulation promotes productions of reactive oxygen species and nitric oxide and apoptotic cell death in Chinese hamster ovary (CHO) cells under oxidative stress, 9th Hong Kong Medical Research Conference. 2004, 12.

Shen J., Lee W.S. and Fung P.C.W., Reactive oxygen species mediate intracellular cholesterol accumulation via modulating caveolin-1 expression in Chinese hamster ovary cells. , Stress, Signalling and Control. 679th Biochemical Society Meeting at University of Essex, UK, . 2003, 63.

Researcher : Leung AYH

Project Title:	Studies on cytochrome P450 CYP2C9 genetic polymorphism in Chinese patients receiving warfarin
Investigator(s):	Dr. Leung A.Y.H., Prof. Liang R.H.S.
Department:	Medicine
Source(s) of Funding:	Kadoorie Charitable Foundations
Start Date:	09/1999

Abstract:

To characterize the sequences of the CYP2C9 gene in Chinese patients using a polymerase chain reaction (PCR)-restriction endonuclease digestion method; to correlate the occurrence of polymorphic alleles with the dose of warfarin used for anticoagulation.

Project Title:	Adoptive transfer of cellular immunity to herpes zoster in BMT patients by vaccinating their seropositive donors with live-attenuated varicella zoster vaccine
Investigator(s):	Dr. Leung A.Y.H., Prof. Liang R.H.S.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2002

Abstract:

To prevent HZ infection in BMT patients, thereby reducing hospital admissions and preventing secondary complications in this group of patients.

Project Title:	Ex-vivo expansion of haematopoietic stem cells derived from human umbilical blood with special reference to the effects of all-trans retinoic acid (ATRA)
Investigator(s):	Dr. Leung A.Y.H., Prof. Liang R.H.S.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2003

Abstract:

To investigate if ATRA can stimulate expansion of primitive HSC in-vitro, characterized by an increase in scid repopulation; to see if the effects of ATRA are dependent on the presence of stromal feeders; to study the molecular mechnaisms underlying the effects of ATRA on haematopoietic stem/progenitor cells.

List of Research Outputs

Au W.Y., Wong R.W.M., Wong B.C.Y., Lie A.K.W., Liang R.H.S., Leung A.Y.H. and Kwong Y.L., Reduced incidence of acute graft versus host disease of the gut in Chinese carriers of Helicobacter pylori during allogeneic bone marrow transplantation, Annals of Hematology. 2004, 83: 34-37.

Au W.Y., Lie A.K.W., Siu L.L.P., Chan C., Ooi C.G.C., Leung A.Y.H., Liang R.H.S. and Kwong Y.L., Treatment of lymphoma relapses after allogeneic hematopoietic stem cell transplantation with intensive chemotherapy followed by infusion of hematopoietic stem cell from the original donor, Annals of Hematology. 2003, 82(9): 548-551.

Kwok J.S.Y., Leung A.Y.H., Lie A.K.W., Lee T.L., Lau Y.L., Chu P., Jones B.M., Hawkins B.R. and Liang R.H.S., Allo-reactive lymphocytes: Antireceipient helper and cytotoxic T-cell frequencies in bone marrow transplantation, Bone Marrow Transplantation. 2004, 34: 207-213.

Ma E.S.K., Au W.Y., Lie A.K.W., Ng I.O.L., Leung A.Y.H., Tse E.W.C., Liang R.H.S., Lau G. and Kwong Y.L., Liver graft-versus-host disease after donor lymphocyte infusion for relapses of hematologic malignancies post allogeneic hematopoietic stem cell transplantation, Bone Marrow Transplantation. 2004, 34: 57-61.

Ma S.Y., Au W.Y., Chim J.C.S., Lie A.K.W., Lam C.C.K., Tse E.W.C., Leung A.Y.H., Liang R.H.S. and Kwong Y.L., Fludarabine, mitoxantrone and dexamethasone in the treatment of indolent B-and T-cell lymphoid malignancies Chinese patients, British Journal of Haematology. 2004, 124: 754-761.

Researcher : Leung JCK

Project Title:	Role of monocyte and neutrophil in the pathogenesis of IgA nephropathy
Investigator(s):	Dr. Leung J.C.K., Prof. Lai K.N.
Department:	Medicine
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	12/2001

Abstract:

To examine the characteristics of monocyte- and neutrophil- bound IgA in patients and IgAN; to investigate in-depth the role of monocyte and neutrophil in the handling and metabolism of IgA in IgAN; to explore the pathophysiologic effect of polymeric IgA from patients on monocyte and neutrophil.

Project Title:	Characterization of differentially charged IgA in IgA nephropathy
Investigator(s):	Dr. Leung J.C.K., Prof. Lai K.N.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	01/2003
Completion Date:	12/2003

Abstract:

To characterize the glycosylation profile, size and possible components of IgA₁ molecules bearing different charges isolated from IgAN patients; to investigate the role of leucocytes and hepatocytes in the handling and metabolism of different charges of IgA₁, in IgAN.

Project Title:	Serum markers for monitoring the onset and outcome of severe acute respiratory syndrome (SARS)-associated acute respiratory distress syndrome (ARDS)
Investigator(s):	Dr. Leung J.C.K., Prof. Lai K.N., Prof. Tam S.C.F., Dr. Wu A.Y.Y.
Department:	Medicine
Source(s) of Funding:	SARS Research Fund
Start Date:	07/2003

Abstract:

To search for potential markers in the serum for predicting the onset and outcome of SARS-associated ARDS.

Project Title:	The roles of electrical charge of IgA1 in the pathogenesis of IgA nephropathy
Investigator(s):	Dr. Leung J.C.K., Prof. Lai K.N.
Department:	Medicine
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	09/2003

Abstract:

To characterize the glycosylation profile, size and possible components of IgA(1) molecules bearing different charges isolated from IgAN patients; to investigate the role of leucocytes and hepatocytes in the handling and metabolism of different charges of IgA(1) in IgAN; to explore the pathophysiologic effects of different charges of IgA(1) from IgAN patients on human mesangial cells.

Project Title:	The roles of electrical charge of IgA1 in the pathogenesis of IgA nephropathy
Investigator(s):	Dr. Leung J.C.K., Prof. Lai K.N.
Department:	Medicine
Source(s) of Funding:	RGC Projects (Block Grant Funded)
Start Date:	09/2003

Abstract:

Project Title:	The role of transforming growth factor-b and vascular endothelial growth factor in the pathogenesis of peritoneal membrane dysfunction
Investigator(s):	Dr. Leung J.C.K., Prof. Lai K.N.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	02/2004

Abstract:

To examine the pathophysiological effects of PDFs and their components on peritoneal cells; to understand the mechanism of TGF-b and VEGF expression and their regulation inperitoneal cells.

List of Research Outputs

Chan L.Y., Leung J.C.K., Tsang W.L., Chan D.T.M., Tang S.C.W. and Lai K.N., Activation Of Human Proximal Renal Tubular Epithelial Cells By Mediators Released From Mesangial Cells Cultured With IgA, Journal of the American Society of Nephrology. 2003, 14: 375A.

Guo H., Leung J.C.K., Chan L.Y., Chan D.T.M. and Lai K.N., The pathogenetic role of immunoglobulin G from patients with systemic lupus erythematosus in the development of lupus pleuritis, Rheumatology. 2004, 43: 286-293.

Lai K.N., Lam M.F. and Leung J.C.K., Peritoneal function: the role of aquaporins, Peritoneal Dialysis International. 2003, 23 (Suppl 2): S20-S25.

Lai K.N., Tang S.C.W., Guh J.Y., Chuang T.D., Lam M.F., Chan L.Y., Tsang W.L. and Leung J.C.K., Polymeric IgA1 from patients with IgA nephropathy upregulates transforming growth factor-beta synthesis and signal transduction in human mesangial cells via the renin-angiotensin system, Journal of American Society of Nephrology. 2003, 14: 3127-3137.

Leung J.C.K., Chan L.Y., Tsang W.L., Tang S.C.W. and Lai K.N., Anti-Macrophage Migration Inhibitory Factor Reduces Transforming Growth Factor-1b Expression In Experimental IgA Nephropathy, Journal of the American Society of Nephrology. 2003, 14: 408A.

Tang S.C.W., Leung J.C.K., Tang A., Ho Y.W., Chan L.Y., Chan D.T.M. and Lai K.N., A Prospective, Randomized, Case-Controlled Study On The Efficacy Of Mycophenolate Mofetil For IgA Nephropathy Patients With Persistent Proteinuria Despite Angiotensin Blockade, Journal of the American Society of Nephrology. 2003, 14: 752A.

Tang S.C.W., Leung J.C.K., Chan L.Y., Tsang W.L., Chen X., Zhou W., Lai K.N. and Sacks S.H., Regulation of complement C3 and C4 synthesis in human peritoneal mesothelial cells by peritoneal dialysis fluid, Clinical & Experimental Immunology. 2004, 136: 85-94.

Wang Y., Du Y., Leung J.C.K., Maxwell P., Lai K.N. and Li Y., Megsin 2093TT Genotype Is Associated With A Protective Role In Iga Nephropathy, Journal of the American Society of Nephrology. 2003, 14: 104A.

Yu C.M., Lai K.W.H., Li P.S., Lam K.Y., Leung J.C.K. and Lai K.N., Normalization of renal aquaporin-2 water channel expression by fosinopril, valsartan, and combination therapy in congestive heart failure: a new mechanism of action, Journal of Molecular and Cellular Cardiology. 2004, 36: 445-453.

Researcher : Leung JKH

List of Research Outputs

Chan D.T.M., Tsang R.C.W., Leung J.K.H. and Yung S.S.Y., Modulation of hyaluronan synthesis in human mesangial cells after stimulation with Anti-DNA antibodies from patients with lupus nephritis, Journal of American Society of Nephrology. 2003, 14: 594A.

Yung S.S.Y., Leung J.K.H., Liu Z.H., Li L.S. and Chan D.T.M., Emodin abrogates peritoneal dialysate induction of pro-inflammatory/fibrotic mediators and morphological changes in human peritoneal mesothelial cells, 9th Medical Reserach Conference. 7-8 February. 2004, Abstract NP-01.

Yung S.S.Y., Leung J.K.H., Liu Z.H., Li L.S. and Chan D.T.M., Emodin abrogates peritoneal dialysis fluid induction of matrix protein synthesis and morphologic changes in human peritoneal mesothelial cells, Journal of American Society of Nephrology. 2003, 14: 645A.

Zhang Q., Yung S.S.Y., Leung J.K.H. and Chan C.Y., Alpha-actinin and F-actin expression is modulated by elevated glucose concentration in human mesangial cells, 9th Medical Research Conference. 7-8 February . 2004, Abstract NP-05.

Researcher : Leung TM

List of Research Outputs

Ho J.C.M., Tipoe G.L., Zheng L., Leung T.M., Tsang K.W.T., Shum D.K.Y., Lau W.C.S., Mak J.C.W., Lam W.K. and Ip M.S.M., In vitro study of regulation of IL-6 production in bronchiectasis, Respiratory Medicine. 2004, 98: 334-341.

Researcher : Leung YH

List of Research Outputs

Cheung B.M.Y., Hwang I.S.S., Li Y.Y., O W.S., Tsang K.W.T., Leung Y.H., Kumana C.R. and Tang F., Increased adrenomedullin expression in lungs in endotoxaemia, Journal of Endocrinology. Bristol, Society for Endocrinology, 2004, 181(2): 339-345.

Cheung B.M.Y., Leung Y.H., Wong L.Y.F., Man Y.B., Lau C.P. and Kumana C.R., Urotensin II in hypertension, Hong Kong Medical Journal. 2003, 9(1) Suppl: 24.

Leung W.C.H., Ooi C.G.C., Mak J.C.W., Leung Y.H., Leung K.M., Lam W.K., Tsang K.W.T. and Tipoe G.L., Animal model of bronchiectasis, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: A-06.

Tsang K.W.T., Tipoe G.L., Sun J.Z., Mak J.C.W., Leung Y.H., Yan C.P.K., Ko K.W., Ooi C.G.C., Ho P.L., Ho J.C.M. and Lam W.K., Central microtubular ciliary defects are of clinical significance in bronchiectasis, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia. 2003, Abstract Book PP6-20: p.199.

Tsang K.W.T., Tipoe G.L., Sun J.Z., Mak J.C.W., Leung Y.H., Yan C.P.K., Ko K.W., Ooi C.G.C., Ho P.L., Ho J.C.M. and Lam W.K., Ciliary central microtubular orientation is of no clinical significance in bronchiectasis, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia. 2003, Abstract Book PP6-21: p.200.

Tsang K.W.T., Tipoe G.L., Sun J.Z., Mak J.C.W., Leung Y.H., Yan C.P.K., Ko K.W., Ooi C.G.C. and Lam W.K., Clinical significance of ciliary abnormalities in bronchiectasis, European Respiratory Journal. 2003, suppl 22(45): P559.

Tsang K.W.T., Tipoe G.L., Sun J.Z., Leung Y.H., Ho P.L., Yuen K.Y., Mak J.C.W. and Lam W.K., Helicobacter pylori exotoxin disrupts ciliary beating and ultrastructure of human airway mucosa, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia. 2003, Abstract Book PP6-22: p.201.

Researcher : Li CS

List of Research Outputs

Lam M.F., Lo W.K., Li C.S., Wong A., Cheung K.O., Tong K.L. and Lai K.N., A Multi-Center Prospective Study For Adequacy Of Dialysis Of Asian Patients In Long-Term Peritoneal Dialysis, Journal of the American Society of Nephrology. 2003, 14: 209A.

Researcher : Li FK

List of Research Outputs

Chim J.C.S., Li F.K. and Chan K.W., Cast nephropathy in multiple myeloma, Haematologica. 2004, 89(4): EIM08.

Lam M.F., Lo W.K., Lui S.L., Li F.K., Chan D.T.M. and Lai K.N., Eosinophilic Peritonitis Has Deleterious Effect On Peritoneal Dialysis Patients Survival, Journal of the American Society of Nephrology. 2003, 14: 862A.

Li F.K., Lai C.K., Poon W.T., Chan A.Y.W., Chan K.W., Tse K.C., Chan D.T.M. and Lai K.N., Aggravation of non-steroidal anti-inflammatory drug-induced hepatitis and acute renal failure by slimming drug containing anthraquinones, Nephrology Dialysis Transplantation. 2004, 19(7): 1916-1917.

Li F.K., Yip T., Tse K.C., Chan D.T.M. and Lai K.N., Artificial Stiffness And Central Aortic Blood Pressure As Determined By Pulse Wave Analysis In Chronic Dialysis And Post-Renal Transplant Patients, Journal of the American Society of Nephrology. 2003, 14: 535A.

Li F.K., Tse K.C., Lam M.F., Yip T.P.S., Lui S.L., Chan G.S.W., Chan K.W., Chan E.Y.T., Choy C.B.Y., Lo W.K., Chan D.T.M. and Lai K.N., Incidence and outcome of antiglomerular basement membrane disease in Chinese, Nephrology (Carlton). 2004, 9: 100-104.

Lui S.F., Li F.K., Choy C.B.Y., Chan D.T.M., Lo W.K. and Lai K.N., Long-term Outcome of Isoniazid Prophylaxis Against Tuberculosis in Chinese Renal Transplant Recipients. , Transplant Infectious Disease. 2004, 6: 55-56.

Tse K.C., Lam M.F., Yip P.S., Li F.K., Lai K.N. and Chan D.T.M., A long-term study on hyperlipidemia in stable renal transplant recipients, Clinical Transplantation. 2004, 18: 274-280.

Tse K.C., Chan D.T.M., Wong S.S.Y., Chan K.W., Lam M.F., Chan K.H.N., Li F.K., Chung B.C.Y. and Lai K.N., Granulomatous interstitial nephritis of the allograft kidney associated with rhodococcal pulmonary infection. Nephrol Dial Transplant, Nephrology Dialysis Transplantation. 2004, 19: 486-490.

Tse K.C., Lam M.F., Yip P.S., Li F.K., Choy C.B.Y., Lai K.N. and Chan D.T.M., Idiopathic Minimal Change Nephrotic Syndrome In Older Adults: Steroid Responsiveness And Pattern Of Relapses, Nephrology, Dialysis and Transplantation. 2003, 18: 1316-1320.

Tse K.C., Li F.K., Chan D.T.M. and Lai K.N., Listeria Monocytogenes Peritonitis Complicated By Septic Shock In A Patient On Continuous Ambulatory Peritoneal Dialysis, Clinical Nephrology. 2003, 60: 61-62.

Tse K.C., Yip P.S., Lam M.F., Choy C.B.Y., Li F.K., Lui S.L., Lo W.K., Chan D.T.M. and Lai K.N., Star Fruit Intoxication In Uraemic Patients: Case Series And Review Of The Literature, Internal Medicine Journal. 2003, 33: 314-316.

Researcher : Li G (Li Guoqing)

List of Research Outputs

Li G., Xia H.H.X., Chen M.H., Peng J., Gu Q., Cui J., Cho C.H., Lam S.K., Lin M.C., Berg D.E., Feng Z., Langenbach R., Kung H. and Wong B.C.Y., Cyclooxygenase-2 Gene Disruption Enhances Gastric Inflammation but Inhibits Gastric Epithelial Proliferation Induced by H. pylori Infection, Gastroenterology. 2004, 126 (4 Suppl 2): W907.

Xiao G., Zhou J., Cheung Y.F., Li G. and Wong T.M., Effect of U50,488H on the outward rectifier and ultra-rapid potassium currents in human atrial myocytes. , European Journal of Pharmacology. 2003, 473: 97-103.

Yang Y., Lin M.C., Ching Y.P., Lam S.K., Xia H.H.X., Tu S., Zou B., Wang J., Li G., He H., Gu Q., Peng J., Kung H. and Wong B.C.Y., FHL2 As a Co-Factor of XAF1 in the Induction of Apoptosis, Gastroenterology. 2004, 126 (4 Suppl 2): S938.

Researcher : Li G (Li Geng)

List of Research Outputs

Li G., Cheung R.T.F., Au Yeung K.M. and Yang E.S., A fMRI study of language-implicated acupoint in stroke patients with expressive aphasia, Society for Neuroscience 2003 Annual Meeting. 2003.

Li G., Cheung R.T.F., Au Yeung K.M. and Yang E.S., A fMRI study on activation of principal and non-principal sites during acupuncture of the hands in stroke patients with expressive aphasia, The 11th Chinese Congress of Radiology. 2003.

Li G., Cheung R.T.F., Au Yeung K.M. and Yang E.S., A functional magnetic resonance imaging study of sensory-deficit-related acupoints in stroke patients with persistent sensory deficits, Neurology. 2004, 62(Suppl 5): A536.

Li G., Cheung R.T.F., Lee T.M.C. and Yang E.S., An fMRI Study of Neural Activations in the Aged and Illiterates, ISMRM, 12th Scientific Meeting & Exhibition. Kyoto, Japan, 2004, 1156.

Li G., Huang L., Cheung R.T.F., Liu S.R., Ma Q. and Yang E.S., Cortical activations upon stimulation of the sensorimotor-implicated acupoints, Magnetic Resonance Imaging. 2004, 22: 639-644.

Researcher : Li GR

Project Title:	Volume-sensitive chloride current and cell volume regulation in human atrial myocytes
Investigator(s):	Dr. Li G.R., Dr. Chiu C.S.W., Prof. Lau C.P., Dr. Tse H.F.
Department:	Faculty of Medicine
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	12/2001

Abstract:

To determine the intracellular signaling pathways that regulate I_Cl.vol and cell volume in human atrium; to determine whether I_Cl.vol is persistently activated in atrial myocytes from patients with dilated atrial cardiomyopathy.

Project Title:	Effects of calcium channel blockers on repolarization potassium currents in human atrial cells
Investigator(s):	Dr. Li G.R., Dr. Chiu S.W.
Department:	Faculty of Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2003

Abstract:

To evaluate the effects of diltiazem and verapamil on I[to1] and I[Kur] in human atrial cells.

Project Title:	Ionic channels of mesenchymal stem cells from bone marrow and cell proliferation
Investigator(s):	Dr. Li G.R., Dr. Chung S.S.M., Prof. Lau C.P., Dr. Tse H.F.
Department:	Faculty of Medicine
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	12/2003

Abstract:

To analyze the molecular identities of IK(IR) and IK(DR) in MSC(s) from rat bone marrow with reverse transcript-polymeterase chain reaction (RT-PCR), immunocytochemistry, Western blot analysis, and patch clamp techniques; to test if IK(DR) and I(Na) are involved in the proliferation of rat MSC(s) by determining cell proliferation in the absence and presence of channel blockers and modulators.

Project Title:	Ionic channels of mesenchymal stem cells from bone marrow and cell proliferation
Investigator(s):	Dr. Li G.R., Dr. Chung S.S.M., Prof. Lau C.P., Dr. Tse H.F.
Department:	Faculty of Medicine
Source(s) of Funding:	RGC Projects (Block Grant Funded)
Start Date:	12/2003

Abstract:

Project Title:	Effects of the compound a from the TCM Xuelianhua on Ionic channel currents in cardiac myocytes
Investigator(s):	Dr. Li G.R., Prof. Lau C.P.
Department:	Faculty of Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	12/2003

Abstract:

To study : (1) the effects of the compound A on inward sodium current INa and calcium current (ICa); (2) effects of the compound A on outward repolarization currents, i.e. inwardly-rectifying potassium current (IK1), rapid and slow delayed rectifier potassium currents (IKr and IKs) in guinea pig and goad ventricular myocytes.

Researcher : Li KT

List of Research Outputs

Lee R...S...Y., Fraser R...C., Lam C.L.K., Ho K...S. and Li K.T., Effects of SARS on consultations in primary care in Hong Kong., Hong Kong Practitioner. Hong Kong, 2003, 25 (11): 532-541.

Researcher : Li LSW

List of Research Outputs

Yip J.T.H., Lee T.M.C., Ho S.L., Tsang T.K.L. and Li L.S.W., Emotion recognition in patients with idiopathic Parkinson's disease., Movement Disorders. New York, USA, John-Wiley & Sons, Inc, 2003, 18(10): 1115-1122.

Researcher : Li PS

List of Research Outputs

Yu C.M., Lai K.W.H., Li P.S., Lam K.Y., Leung J.C.K. and Lai K.N., Normalization of renal aquaporin-2 water channel expression by fosinopril, valsartan, and combination therapy in congestive heart failure: a new mechanism of action, Journal of Molecular and Cellular Cardiology. 2004, 36: 445-453.

Researcher : Liang RHS

Project Title:	Translational research in blood cancers and stem cell transplantation
Investigator(s):	Prof. Liang R.H.S., Prof. Kwong Y.L.
Department:	Medicine
Source(s) of Funding:	Kadoorie Charitable Foundations
Start Date:	01/1999

Abstract:

Modern molecular and cellular techniques are applied for the diagnosis and treatment of blood cancers.

Project Title:	Molecular genetics of common cancers in Hong Kong
Investigator(s):	Prof. Liang R.H.S., Prof. Kwong Y.L.
Department:	Medicine
Source(s) of Funding:	Kadoorie Charitable Foundations
Start Date:	03/2000

Abstract:

To investigate the genetic changes of the common cancers in Hong Kong.

Project Title:	Quantification of circulating Epstein Barr viral DNA in patients with malignant lymphoma: diagnostic and prognostic significance
Investigator(s):	Prof. Liang R.H.S., Dr. Au W.Y., Prof. Kwong Y.L.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2002

Abstract:

To define if circulating Epstein-Barr viral (EBV) DNA can be correlated with tumor load in patients with malignant lymphoma; to define the biologic significance and propgnostic value of circulating EBV DNA in malignant lymphoma.

Project Title:	Molecular determinants of arsenic resistance in APL and prognostic factors of APL in the post arsenic era
Investigator(s):	Prof. Liang R.H.S., Dr. Au W.Y., Prof. Kwong Y.L.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2003

Abstract:

To define the relative significance of FLT-3 mutation and aberrant p15 methylation in prognostication of acute promyelocytic leukaemia (APL) in the era of arsenic salvage; to define the molecular role of molecular transport proteins, protein kinase and tumor suppressor genes in arsenic resistant APL.

Project Title:	Adoptive transfer of herpes zoster cellular immunity to BMT patients by vaccination of seropositive donors with live-attenuated varicella zoster vaccine
Investigator(s):	Prof. Liang R.H.S., Dr. Leung A.Y.H.
Department:	Medicine
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	12/2003

Abstract:

To study whether the use of live-attenuated VZV vaccine in VZV-seropositive donors prior to BMT achieves three objectives: boosts the cellular and humoral immunity of the donors, transfers immunity to patients post BMT, and protects BMT patients from the development of HZ after transplantation.

Project Title:	Adoptive transfer of herpes zoster cellular immunity to BMT patients by vaccination of seropositive donors with live-attenuated varicella zoster vaccine
Investigator(s):	Prof. Liang R.H.S., Dr. Leung A.Y.H.
Department:	Medicine
Source(s) of Funding:	RGC Projects (Block Grant Funded)
Start Date:	12/2003

Abstract:

List of Research Outputs

Ambekar C.S., Kumana C.R., Liang R.H.S. and Cheung B.M.Y., Chloramphenicol succinate as a competitive substrate and inhibitor of succinate dehydrogenase: relation to its mechanisms of toxicity, Hong Kong Medical Journal. 2003, 9(1) Suppl: 64.

Ambekar C.S., Lee J.S.K., Cheung B.M.Y., Chan L.C., Liang R.H.S. and Kumana C.R., Chloramphenicol succinate, a competitive substrate and inhibitor of succinate dehdrogenase : possible reason for its toxicity., Toxicology in Vitro. 2004, 18: 441-447.

Ambekar C.S., Kumana C.R., Liang R.H.S. and Cheung B.M.Y., Traditional Chinese medicine: effect on bone marrow and peripheral blood cell counts and enzyme induction, Hong Kong Medical Journal. 2003, 9(1) Suppl: 63.

Au W.Y., Lie A.K.W., Liang R.H.S., Kwong Y.L., Yau C.C., Cheung M.M.C., Ngan K.C., Lau W.H., Wong K.H., Yiu H.Y., Cheng H.C., Au K.H. and Chang J.K.C., Autologous stem cell transplantation for nasal NK/T-cell lymphoma: a progress report on its value, Annals of Oncology. 2003, 14: 1673-1676.

Au W.Y., Wong R.W.M., Khoo U.S. and Liang R.H.S., Concurrent aggressive gastrointestinal stromal tumour (GIST) and Burkitt’s lymphoma., Journal of Clinical Oncology. 2003, 21: 1417 – 1418.

Au W.Y., Fung A., Chim J.C.S., Lie A.K.W., Liang R.H.S., Ma E.S.K., Chan C.H., Wong K.F. and Kwong Y.L., FLT-3 aberrations in acute promyelocytic leukaemia: clinicopathological associations and prognostic impact, British Journal of Haematology. 2004, 125(4): 463-469.

Au W.Y., Gascoyne R.D., Gallaghar R.E., Nhu L., Klasa R.D., Liang R.H.S., Choy C.K.W., Foo W. and Connors J.M., Hodgkin's disease in Chinese migrants to British Columbia: a 25-year survey, Annals of Oncology. 2004, 15: 626-630.

Au W.Y., Fung T.K., Ma E.S.K., Liang R.H.S. and Kwong Y.L., Low frequency of FLT3 gene internal tandem duplication and activating loop mutation in therapy-related acute myelocyticleukemia and myelodysplastic syndrome, Cancer Genetics and Cytogenetics. 2004, 149(2): 169-172.

Au W.Y., Cheng V.C.C., Ho P.L., Yuen K.Y., Hung I., Ma S.Y., Lie A.K.W., Liang R.H.S. and Kwong Y.L., Non tuberculous mycobacterial infections in Chinese hematopoietic stem cell transplantation recipients., Bone Marrow Transplantation. 2003, 32: 709-714.

Au W.Y., Wong R.W.M., Wong B.C.Y., Lie A.K.W., Liang R.H.S., Leung A.Y.H. and Kwong Y.L., Reduced incidence of acute graft versus host disease of the gut in Chinese carriers of Helicobacter pylori during allogeneic bone marrow transplantation, Annals of Hematology. 2004, 83: 34-37.

Au W.Y., Lie A.K.W., Siu L.L.P., Chan C., Ooi C.G.C., Leung A.Y.H., Liang R.H.S. and Kwong Y.L., Treatment of lymphoma relapses after allogeneic hematopoietic stem cell transplantation with intensive chemotherapy followed by infusion of hematopoietic stem cell from the original donor, Annals of Hematology. 2003, 82(9): 548-551.

Au W.Y., Lie A.K.W., Chan C., Pang A.W.K., Liang R.H.S., Ma E.S.K., Choy C.K.W. and Kwong Y.L., Treatment of post-renal transplantation lymphoproliferative disease manifesting as plasmacytoma with non-myeloablative hematopoietic stem cell transplantation from the same kidney donor, American Journal of Hematology. 2003, 74: 283-6.

Chen Y.W., Liang A.C.T., Au W.Y., Chu K.M., Wong K.Y., Hu X., Lu L., Tang J.C.O., Chan K.W., Beh S.L., Kwong Y.L., Liang R.H.S. and Srivastava G., Multiple BCL6 translocation partners in individual cases of gastric lymphoma, Blood. 2003, 102: 1931-1932.

Chim J.C.S., Wong A.S.Y. and Liang R.H.S., Aberrant gene promoter methylation in acute promyelocytic leukaemia: profile and prognostic significance, British Journal of Haematology. 2003, 122(4): 571-578.

Chim J.C.S., Fung T.K. and Liang R.H.S., Disruption of INK4/CDK/Rb Cell cycle pathway by gene hypermethylation in multiple myeloma and MGUS., Leukemia. 2003, 76: 169-176.

Chim J.C.S., Hu W.H., Loong F., Ooi C.G.C. and Liang R.H.S., Gastrointestinal manifestations of mantle cell lymphoma, Gastrointestinal Endoscopy. 2003, 59: 931-933.

Chim J.C.S., Loong F., Ooi C.G.C. and Liang R.H.S., Mantle cell lymphoma of prostate gland, Journal of Clinical Oncology. 2003, 21: 4456-4458.

Chim J.C.S., Kwong Y.L., Fung T.K. and Liang R.H.S., Methylation profiling in multiple myeloma, Leukemia Research. 2004, 28: 379-385.

Chim J.C.S., Shek T.W.H., Chung L.P. and Liang R.H.S., Multiple lymphomatous polyposis in lymphoma of colon, Journal of Clinical Oncology. 2003, 953 – 955.

Chim J.C.S., Ma A.Y., Au W.Y., Choy C.K.W., Lie A.K.W., Liang R.H.S., Yau C.C. and Kwong Y.L., Primary nasal natural killer cell lymphoma : long term treatment outcome and relationship with the international prognostic index., Blood. 2004, 103: 216-221.

Chim J.C.S., Fung T.K., Cheung W.C., Liang R.H.S. and Kwong Y.L., SOCS1 and SHP1 Hypermethylation in Multiple Myeloma: Implications for Epigenetic Activation of the Jak/STAT pathway, Blood. 2004, 103: 4630-4635.

Chim J.C.S., Ooi C.G.C., Loong F. and Liang R.H.S., Solitary bone plasmacytoma : Role of MRI and PET, Journal of Clinical Oncology. 2004, 22: 1328-1330.

Kwok J.S.Y., Leung A.Y.H., Lie A.K.W., Lee T.L., Lau Y.L., Chu P., Jones B.M., Hawkins B.R. and Liang R.H.S., Allo-reactive lymphocytes: Antireceipient helper and cytotoxic T-cell frequencies in bone marrow transplantation, Bone Marrow Transplantation. 2004, 34: 207-213.

Lam M.F., Ooi C.G.C., Lam B., Ho J.C.M., Seto W.H., Ho P.L., Wong P.C., Liang R.H.S., Lam W.K. and Tsang K.W.T., An indolent case of severe acute respiratory syndrome, American Journal of Respiratory and Critical Care Medicine. 2004, 169(1): 125-128.

Lau G., Yiu H.H.Y., Fong D.Y.T., Cheng H.C., Au W.Y., Lai L.S.F., Cheung M., Zhang H.Y., Lie A.K.W., Ngan K.C. and Liang R.H.S., Early Is Superior to Deferred Preemptive Lamivudine Therapy for Hepatitis B Patients Undergoing Chemotherapy, Gastroenterology. 2003, 125: 1742-1749.

Lau G., Zhang H.Y., Luk J.M.C., Locarnini S. and Liang R.H.S., Pre-emptive use of lamivudine reduces hepatitis B exacerbation after allogeneic hematopoietic cell transplantation, Hepatology. 2004, 39: 867-868.

Lau G., Lie A.K.W. and Liang R.H.S., Preemptive lamivudine in hepatitis B patients undergoing chemotherapy, Gastroenterology. 2004, 126(7): 1924-5.

Ma E.S.K., Au W.Y., Lie A.K.W., Ng I.O.L., Leung A.Y.H., Tse E.W.C., Liang R.H.S., Lau G. and Kwong Y.L., Liver graft-versus-host disease after donor lymphocyte infusion for relapses of hematologic malignancies post allogeneic hematopoietic stem cell transplantation, Bone Marrow Transplantation. 2004, 34: 57-61.

Ma S.Y., Au W.Y., Chim J.C.S., Lie A.K.W., Lam C.C.K., Tse E.W.C., Leung A.Y.H., Liang R.H.S. and Kwong Y.L., Fludarabine, mitoxantrone and dexamethasone in the treatment of indolent B-and T-cell lymphoid malignancies Chinese patients, British Journal of Haematology. 2004, 124: 754-761.

Ma S.Y., Au W.Y., Ng I.O.L., Lie A.K.W., Liang R.H.S., Lau G. and Kwong Y.L., Hepatitic graft-versus-host disease after hematopoietic stem cell transplantation : clinicopathologic features and prognostic implication, Transplantation. 2004, 77: 1252-1259.

Ma S.Y., Lau G., Cheng V.C.C. and Liang R.H.S., Hepatitis B reactivation in patients positive for hepatitis B surface antigen undergoing autologous hematopoietic cell transplantation, Leukemia and Lymphoma. 2003, 44(8): 1281-5.

Ma S.Y., Lie A.K.W., Au W.Y., Chim J.C.S., Kwong Y.L. and Liang R.H.S., Non-myeloablative allogeneic peripheral stem cell transplantation for multiple myeloma, Hong Kong Medical Journal. 2004, 10: 77-83.

Ma S.Y., Au W.Y., Ng I.O.L., Lie A.K., Leung A.Y., Liang R.H.S., Lau G. and Kwong Y.L., Role of liver biopsy in the management of liver dysfunction after hematopoietic stem-cell transplantation in a hepatitis B virus-prevalent patient population, Transplantation. 2003, 7691): 169-176.

Shen L., Liang A.C.T., Lu L., Au W.Y., Wong K.Y., Tin P.C., Chan K.W., Ko K.H., Chen W.Y.W., Beh S.L., Shimizu N., Tsuchiyama T., Tang J.C.O., Kwong Y.L., Liang R.H.S. and Srivastava G., Aberrant BCL10 nuclear expression in nasal NK/T-cell lymphoma, Blood. 2003, 102(4): 1553-1554.

Shen L., Liang A.C.T., Au W.Y., Lu L., Chen W.Y.W., Wong K.Y., Tang J.C.O., Chan K.W., Beh S.L., Kwong Y.L., Liang R.H.S. and Srivastava G., BCL10 mutations are irrelevant to its aberrant nuclear localization in nasal NK/T-cell lymphoma, Leukemia. 2003, 17(11): 2240-2242.

Researcher : Lie AKW

List of Research Outputs

Au W.Y., Lie A.K.W., Liang R.H.S., Kwong Y.L., Yau C.C., Cheung M.M.C., Ngan K.C., Lau W.H., Wong K.H., Yiu H.Y., Cheng H.C., Au K.H. and Chang J.K.C., Autologous stem cell transplantation for nasal NK/T-cell lymphoma: a progress report on its value, Annals of Oncology. 2003, 14: 1673-1676.

Au W.Y., Ma S.Y., Ooi C.G.C. and Lie A.K.W., Disseminated zoster, hyponatremia, severe abdominal pain and leukemia relapse: an extended clinical quartet after bone marrow transplantation, British Journal of Dermatology. 2003, 148: 862-865.

Au W.Y., Fung A., Chim J.C.S., Lie A.K.W., Liang R.H.S., Ma E.S.K., Chan C.H., Wong K.F. and Kwong Y.L., FLT-3 aberrations in acute promyelocytic leukaemia: clinicopathological associations and prognostic impact, British Journal of Haematology. 2004, 125(4): 463-469.

Au W.Y., Lie A.K.W., Ma E.S.K., Lau G., Chan C. and Kwong Y.L., Late onset pure red cell aplasia due to delayed lymphoid engraftment complicating ABO mismatched hematopoietic stem cell transplantaion, Transfusion. 2004, 44: 946-947.

Au W.Y., Cheng V.C.C., Ho P.L., Yuen K.Y., Hung I., Ma S.Y., Lie A.K.W., Liang R.H.S. and Kwong Y.L., Non tuberculous mycobacterial infections in Chinese hematopoietic stem cell transplantation recipients., Bone Marrow Transplantation. 2003, 32: 709-714.

Au W.Y., Wong R.W.M., Wong B.C.Y., Lie A.K.W., Liang R.H.S., Leung A.Y.H. and Kwong Y.L., Reduced incidence of acute graft versus host disease of the gut in Chinese carriers of Helicobacter pylori during allogeneic bone marrow transplantation, Annals of Hematology. 2004, 83: 34-37.

Au W.Y., Lam C.C.K., Lie A.K.W., Pang A.W.K. and Kwong Y.L., T-cell large granular lymphocyte leukemia of donor origin after allogeneic bone marrow transplantation, Americal Journal of Clinical Pathology. 2003, 120: 626-30.

Au W.Y., Lie A.K.W., Siu L.L.P., Chan C., Ooi C.G.C., Leung A.Y.H., Liang R.H.S. and Kwong Y.L., Treatment of lymphoma relapses after allogeneic hematopoietic stem cell transplantation with intensive chemotherapy followed by infusion of hematopoietic stem cell from the original donor, Annals of Hematology. 2003, 82(9): 548-551.

Au W.Y., Lie A.K.W., Chan C., Pang A.W.K., Liang R.H.S., Ma E.S.K., Choy C.K.W. and Kwong Y.L., Treatment of post-renal transplantation lymphoproliferative disease manifesting as plasmacytoma with non-myeloablative hematopoietic stem cell transplantation from the same kidney donor, American Journal of Hematology. 2003, 74: 283-6.

Chim J.C.S., Ma A.Y., Au W.Y., Choy C.K.W., Lie A.K.W., Liang R.H.S., Yau C.C. and Kwong Y.L., Primary nasal natural killer cell lymphoma : long term treatment outcome and relationship with the international prognostic index., Blood. 2004, 103: 216-221.

Kwok J.S.Y., Leung A.Y.H., Lie A.K.W., Lee T.L., Lau Y.L., Chu P., Jones B.M., Hawkins B.R. and Liang R.H.S., Allo-reactive lymphocytes: Antireceipient helper and cytotoxic T-cell frequencies in bone marrow transplantation, Bone Marrow Transplantation. 2004, 34: 207-213.

Lau G., Yiu H.H.Y., Fong D.Y.T., Cheng H.C., Au W.Y., Lai L.S.F., Cheung M., Zhang H.Y., Lie A.K.W., Ngan K.C. and Liang R.H.S., Early Is Superior to Deferred Preemptive Lamivudine Therapy for Hepatitis B Patients Undergoing Chemotherapy, Gastroenterology. 2003, 125: 1742-1749.

Lau G., Lie A.K.W. and Liang R.H.S., Preemptive lamivudine in hepatitis B patients undergoing chemotherapy, Gastroenterology. 2004, 126(7): 1924-5.

Ma E.S.K., Au W.Y., Lie A.K.W., Ng I.O.L., Leung A.Y.H., Tse E.W.C., Liang R.H.S., Lau G. and Kwong Y.L., Liver graft-versus-host disease after donor lymphocyte infusion for relapses of hematologic malignancies post allogeneic hematopoietic stem cell transplantation, Bone Marrow Transplantation. 2004, 34: 57-61.

Ma S.Y., Au W.Y., Chim J.C.S., Lie A.K.W., Lam C.C.K., Tse E.W.C., Leung A.Y.H., Liang R.H.S. and Kwong Y.L., Fludarabine, mitoxantrone and dexamethasone in the treatment of indolent B-and T-cell lymphoid malignancies Chinese patients, British Journal of Haematology. 2004, 124: 754-761.

Ma S.Y., Au W.Y., Ng I.O.L., Lie A.K.W., Liang R.H.S., Lau G. and Kwong Y.L., Hepatitic graft-versus-host disease after hematopoietic stem cell transplantation : clinicopathologic features and prognostic implication, Transplantation. 2004, 77: 1252-1259.

Ma S.Y., Lie A.K.W., Au W.Y., Chim J.C.S., Kwong Y.L. and Liang R.H.S., Non-myeloablative allogeneic peripheral stem cell transplantation for multiple myeloma, Hong Kong Medical Journal. 2004, 10: 77-83.

Researcher : Lo LF

List of Research Outputs

Cheung B.M.Y., Lo L.F., Chan S.K., Chan M.Y., Fong D.Y.T., Leung R.K.W., Wong S., Wong V., Lam K.S.L., Lau C.P., Lee P.W.H. and Karlberg J.P.E., Effect of qigong on hypertension: a randomised controlled study, Hong Kong Medical Journal. 2003, 9(1) Suppl: 21.

Cheung B.M.Y., Lam T.H., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Man Y.B., Cheng C.H., Kumana C.R. and Lau C.P., Follow Up of the Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort (CP17), Seventh Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine: Journal of the Hong Kong College of Cardiology . 2003, 11 (Suppl 1).

Cheung B.M.Y., Lam T.H., Lam K.S.L., Tam S.C.F., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Man Y.B., Cheng C.H., Kumana C.R. and Lau C.P., Follow up of the Hong Kong Cardiovascular risk factor prevalence survey cohort, Hong Kong Medical Journal. 2003, 9(1) Suppl: 27.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., High blood pressure is related to obesity in Hong Kong, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., High blood pressure is related to obesity in Hong Kong, Hong Kong Medical Journal. 2003, 9(1) Suppl: 35.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Lipid profile of the Hong Kong cardiovascular risk factor prevalence study cohort, Hong Kong Medical Journal. 2003, 9(1) Suppl: 22.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Obesity in the Hong Kong cardiovascular risk factor prevalence survey-2 (CRISPS2) cohort, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Cheung B.M.Y., Man Y.B., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of Diabetes Mellitus (DM) in the Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort (P16), Seventh Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine: Journal of the Hong Kong College of Cardiology . 2003, 11 (Suppl 1).

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of diabetes mellitus (DM) in the Hong Kong Cardiovascular risk factor prevalence study cohort, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Cheung B.M.Y., Man Y.B., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of diabetes mellitus (DM) in the Hong Kong Cardiovascular risk factor prevalence study cohort, Hong Kong Medical Journal. 2003, 9(1) Suppl: 19.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of obesity in the Hong Kong Cardiovascular risk factor prevalence survey-2 (CRISPS2), Hong Kong Medical Journal. 2003, 9(1) Suppl: 23.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Relationship between Hypertension and Obesity in Hong Kong, 3rd Asian-Pacific Congress of Hypertension. 2004.

Man Y.B., Cheung B.M.Y., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of hypertension in the Hong Kong cardiovascular risk factor prevalence study cohort, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Researcher : Lo RSK

List of Research Outputs

Choy C.B.Y., Chan D.T.M., Lo R.S.K., Lo W.K. and Lai K.N., Renal transplantation in patients with primary immunoglobulin A nephropathy, Nephrology Dialysis Transplantation. 2003, 18: 2399-2404.

Researcher : Lo WK

List of Research Outputs

Choy C.B.Y., Chan D.T.M., Lo R.S.K., Lo W.K. and Lai K.N., Renal transplantation in patients with primary immunoglobulin A nephropathy, Nephrology Dialysis Transplantation. 2003, 18: 2399-2404.

Lam M.F., Lo W.K., Li C.S., Wong A., Cheung K.O., Tong K.L. and Lai K.N., A Multi-Center Prospective Study For Adequacy Of Dialysis Of Asian Patients In Long-Term Peritoneal Dialysis, Journal of the American Society of Nephrology. 2003, 14: 209A.

Lam M.F., Lo W.K., Lui S.L., Li F.K., Chan D.T.M. and Lai K.N., Eosinophilic Peritonitis Has Deleterious Effect On Peritoneal Dialysis Patients Survival, Journal of the American Society of Nephrology. 2003, 14: 862A.

Li F.K., Tse K.C., Lam M.F., Yip T.P.S., Lui S.L., Chan G.S.W., Chan K.W., Chan E.Y.T., Choy C.B.Y., Lo W.K., Chan D.T.M. and Lai K.N., Incidence and outcome of antiglomerular basement membrane disease in Chinese, Nephrology (Carlton). 2004, 9: 100-104.

Lui S.F., Li F.K., Choy C.B.Y., Chan D.T.M., Lo W.K. and Lai K.N., Long-term Outcome of Isoniazid Prophylaxis Against Tuberculosis in Chinese Renal Transplant Recipients. , Transplant Infectious Disease. 2004, 6: 55-56.

Lui S.L., Chan D.T.M., Lo W.K. and Lai K.N., Chronic inflammatory demyelinating polyneuropathy after initiation of peritoneal dialysis--a distinct clinical entity?, International Journal of Artificial Organs. 2003, 26: 969-971.

Tang S.C.W., Lui S.L., Lo C.Y., Lo W.K., Cheng I.K.P., Lai K.N. and Chan D.T.M., Spousal renal donor transplantation in Chinese subjects: a 10 year experience from a single centre, Nephrology Dialysis Transplantation. 2004, 19: 203-206.

Tse K.C., Yip P.S., Lam M.F., Choy C.B.Y., Li F.K., Lui S.L., Lo W.K., Chan D.T.M. and Lai K.N., Star Fruit Intoxication In Uraemic Patients: Case Series And Review Of The Literature, Internal Medicine Journal. 2003, 33: 314-316.

Researcher : Lo Y

List of Research Outputs

Mok T.M.Y., Yeung J.S.L., Jin O., Chan W.K., Lo Y. and Lau W.C.S., Anti-beta2 glycoprotein I antibodies facilitates phagocytosis of apoptotic neutrophils in patients with systemic lupus erythematosus, The Hong Kong Practitioner. 2003, 9(Suppl 1): 65.

Mok T.M.Y., Chan E.Y.T., Leung K., Lo Y., Wong R.W.S. and Lau W.C.S., Antiphospholipid antibody profiles in Chinese patients with systemic lupus erythematosus, The Hong Kong Practitioner. 2004, 2: RI-04.

Mok T.M.Y., Lao T.T.H., Collins R.J., Leung T.Y., Leung P.Y., Lo Y., Chan D.T.M., Wong R.W.S. and Lau W.C.S., Cervical dysplasia in patients with systemic lupus erythematosus, The Hong Kong Practitioner. 2004, 2: RI-05.

Mok T.M.Y., Leung P.Y., Lao T.T.H., Lo Y., Chan D.T.M., Wong R.W.S. and Lau W.C.S., Clinical predictors of fetal and maternal outcome in Chinese patients with systemic lupus erythematosus, 7th International Congress on SLE and Related Conditions, New York. 2004.

Mok T.M.Y., Lo Y., Chan D.T.M., Wong R.W.S. and Lau W.C.S., Efficacy of chemotherapy for tuberculosis infection in patients with systemic lupus erythematosus in an endemic area, The Hong Kong Practitioner. 2003, 9(Suppl 1): 65.

Mok T.M.Y., Yeung J.S.L., Chan W.K., Leung P.Y., Lo Y. and Lau W.C.S., Sex hormones and apoptosis and immunoglobulin production in systemic lupus erythematosus, The Hong Kong Practitioner. 2003, 9(Suppl 1): 66.

Researcher : Lui SL

List of Research Outputs

Lam M.F., Lo W.K., Lui S.L., Li F.K., Chan D.T.M. and Lai K.N., Eosinophilic Peritonitis Has Deleterious Effect On Peritoneal Dialysis Patients Survival, Journal of the American Society of Nephrology. 2003, 14: 862A.

Li F.K., Tse K.C., Lam M.F., Yip T.P.S., Lui S.L., Chan G.S.W., Chan K.W., Chan E.Y.T., Choy C.B.Y., Lo W.K., Chan D.T.M. and Lai K.N., Incidence and outcome of antiglomerular basement membrane disease in Chinese, Nephrology (Carlton). 2004, 9: 100-104.

Lui S.L., Chan D.T.M., Lo W.K. and Lai K.N., Chronic inflammatory demyelinating polyneuropathy after initiation of peritoneal dialysis--a distinct clinical entity?, International Journal of Artificial Organs. 2003, 26: 969-971.

Tang S.C.W., Leung C.B., Wong K.M., Kwan T.H., Lui S.L., Tsang W.K., Mak S.K., Yu A.W. and Li P.K., Prevalence of kidney disease in Hong Kong: principal results from the Screening for Hong Kong Asymptomatic Renal Population and Evaluation (SHARE) programme., Hong Kong Journal Nephrology. 2004, 6: A1.

Tang S.C.W., Lui S.L., Lo C.Y., Lo W.K., Cheng I.K.P., Lai K.N. and Chan D.T.M., Spousal renal donor transplantation in Chinese subjects: a 10 year experience from a single centre, Nephrology Dialysis Transplantation. 2004, 19: 203-206.

Tse K.C., Yip P.S., Lam M.F., Choy C.B.Y., Li F.K., Lui S.L., Lo W.K., Chan D.T.M. and Lai K.N., Star Fruit Intoxication In Uraemic Patients: Case Series And Review Of The Literature, Internal Medicine Journal. 2003, 33: 314-316.

Researcher : Mak JCW

Project Title:	The role of transforming growth factor-b₁ (TGF-b₁) in the regulation of airway inflammation in bronchiectasis
Investigator(s):	Dr. Mak J.C.W., Prof. Lam W.K., Dr. Tsang K.W.T.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	10/2002
Completion Date:	01/2004

Abstract:

To determine the expression pattern and the amount of TGF-b₁ in bronchial biopsies and bronchoalveolar lavage fluid as well as sputum samples from patients with bronchiectasis.

Project Title:	Serum cytokine levels in convalescent patients with severe acute respiratory syndrome (SARS)
Investigator(s):	Dr. Mak J.C.W., Prof. Lai K.N., Prof. Lam W.K., Dr. Tsang K.W.T.
Department:	Medicine
Source(s) of Funding:	SARS Research Fund
Start Date:	07/2003

Abstract:

To measure a panel of cytokines, including the T helper 1 (Th1) cytokine interferon-gamma (INF-gamma), and the Th2 cytokines interleukin-4 (IL-4), IL-5, IL-6, and granulocyte-macrophage colony-stimulating factor (GM-CSF) in frozen sera from SARS patients in comparison to healthy control subjects.

Project Title:	Effects of pseudomonas aeruginosa pyocyanin and 1-hydroxyphenazine on the regulation of glucocorticoid receptor activation and function in airway epithelial cells in vitro
Investigator(s):	Dr. Mak J.C.W., Dr. Tsang K.W.T.
Department:	Medicine
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	11/2003

Abstract:

To evaluate the effects of Pseudomonas aeruginosa (PA) exotoxins, pyocyanin (PYO) and 1-hydroxyphenazine (1-HP), on the functional and immunological aspects of human airway epithelial cells in vitro, and examine the signaling pathways involved in PYO- or 1-HP-induced responses; to assess the efficacy of various potential novel therapeutic and chemical agents on the effects of these toxins.

Project Title:	Effects of pseudomonas aeruginosa pyocyanin and 1-hydroxyphenazine on the regulation of glucocorticoid receptor activation and function in airway epithelial cells in vitro
Investigator(s):	Dr. Mak J.C.W., Dr. Tsang K.W.T.
Department:	Medicine
Source(s) of Funding:	RGC Projects (Block Grant Funded)
Start Date:	11/2003

Abstract:

Project Title:	Is there an association between TGF-b₁ plasma levels and common polymorphisms with a risk of developing chronic obstructive pulmonary disease (COPD)?
Investigator(s):	Dr. Mak J.C.W., Prof. Chan M.M.W., Dr. Tsang K.W.T.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	02/2004

Abstract:

To study the promoter and coding regions of the TGF-b₁ gene, identify single nucleotide polymorphisms (SNP) in Hong Kong Chinese (i.e. healthy nonsmokers and smokers and patients with COPD) and correlate these with plasma TGF-b₁ level.

List of Research Outputs

Chan M.M.W., Lam W.K., Mak J.C.W., Ho S.P., Chan R.H.W., Tsang K.W.T., Ip M.S.M., Ho J.C.M., Wong M.P. and Tan-Un K.C., Polymorphisms of CYP and GST genes, passive smoke and lung cancer risk in Hong Kong Chinese, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-11.

Ho J.C.M., Tipoe G.L., Zheng L., Leung T.M., Tsang K.W.T., Shum D.K.Y., Lau W.C.S., Mak J.C.W., Lam W.K. and Ip M.S.M., In vitro study of regulation of IL-6 production in bronchiectasis, Respiratory Medicine. 2004, 98: 334-341.

Ho J.C.M., Ho S.P., Chan M.M.W., Mak J.C.W., Ip M.S.M., Wong M.P., Tsang K.W.T. and Lam W.K., Non-small cell lung cancer in Chinese is associated with disturbance in systemic antioxidants profiles , 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-03.

Leung W.C.H., Ooi C.G.C., Mak J.C.W., Leung Y.H., Leung K.M., Lam W.K., Tsang K.W.T. and Tipoe G.L., Animal model of bronchiectasis, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: A-06.

Mak J.C.W., Ho S.P., Tsang K.W.T., Ip M.S.M., Yu W.C., Yew W.W. and Chan M.M.W., Increased transforming growth factor-beta 1 (TGF-beta 1) plasma level in Chinese patients with chronic obstructive pulmonary disease (COPD), American Thoracic Society International Conference, Orlando, USA. May 2004. 169(7): A838.

Mak J.C.W., Hui W.S., Lam W.K. and Tsang K.W.T., Role of pseudomonas aeruginosa pyocyanin in mediating cytokine release in human airway epithelial cells in vitro , 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia. 2003, Abstract Book PP7-05: p.220.

Mak J.C.W., Hui W.S., Pan N.Y., Lam W.K. and Tsang K.W.T., Role of pseudomonas aeruginosa pyocyanin in mediating cytokine release in human airway epithelial cells in vitro, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-02.

Tsang K.W.T., Tipoe G.L., Sun J.Z., Mak J.C.W., Leung Y.H., Yan C.P.K., Ko K.W., Ooi C.G.C., Ho P.L., Ho J.C.M. and Lam W.K., Central microtubular ciliary defects are of clinical significance in bronchiectasis, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia. 2003, Abstract Book PP6-20: p.199.

Tsang K.W.T., Tipoe G.L., Sun J.Z., Mak J.C.W., Leung Y.H., Yan C.P.K., Ko K.W., Ooi C.G.C., Ho P.L., Ho J.C.M. and Lam W.K., Ciliary central microtubular orientation is of no clinical significance in bronchiectasis, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia. 2003, Abstract Book PP6-21: p.200.

Tsang K.W.T., Tipoe G.L., Sun J.Z., Mak J.C.W., Leung Y.H., Yan C.P.K., Ko K.W., Ooi C.G.C. and Lam W.K., Clinical significance of ciliary abnormalities in bronchiectasis, European Respiratory Journal. 2003, suppl 22(45): P559.

Tsang K.W.T., Tipoe G.L., Sun J.Z., Leung Y.H., Ho P.L., Yuen K.Y., Mak J.C.W. and Lam W.K., Helicobacter pylori exotoxin disrupts ciliary beating and ultrastructure of human airway mucosa, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia. 2003, Abstract Book PP6-22: p.201.

Wong M.P., Tipoe G.L., Sun J.Z., Mak J.C.W., Ooi C.G.C., Ip M.S.M., Chan M.M.W., Lam W.K. and Tsang K.W.T., Clinical significance of ciliary abnormalities in bronchiectasis, Annual Scientific Meeting, Hong Kong Thoracic Society & American College of Chest Physicians, 2003. Abstract pp.30.

Researcher : Mak W

List of Research Outputs

Chan K.H., Cheung R.T.F., Mak W., Au Yeung K.M. and Ho S.L., Cerebral venous thrombosis presenting as unilateral headache plus visual blurring in a man with nephrotic syndrome, Hospital Medicine. 2004, 65: 54-55.

Chan K.H., Mak W., Tsang K.L., Fong C.Y.G., Cheng T.S., Cheung R.T.F. and Ho S.L., Idiopathic relapsing transverse myelitis: experience of a regional hospital, 9th Medical Research Conference. 2004.

Chan K.H., Cheung R.T.F., Mak W., Fong C.Y.G., Tsang K.L., Cheng T.S. and Ho S.L., Predictive factors for ischemic strokes complicating tuberculous meningitis, Hong Kong Medical Journal. 2004, 10(Suppl 1): 34.

Cheng T.S., Mak W., Fong C.Y.G., Chan K.H., Ho S.L. and Cheung R.T.F., Clinical relevance of severe initial hypertension in acute intracerebral haemorrhage, Hong Kong Medical Journal. 2004, 10(Suppl 1): 34.

Mak W., Cheng T.S., Fong C.Y.G., Tsang K.L., Chan K.H., Cheung R.T.F. and Ho S.L., Re-exploring the cerebrospinal fluid (CSF) to serum glucose ratio, 9th Medical Research Conference. 2004.

Researcher : Man CWY

List of Research Outputs

Au W.Y., Ma E.S.K., Wan T.S.K., Man C.W.Y. and Kwong Y.L., Pentasomy 8q after cyclophosphamide therapy for fibrosing alveolitis: case report and review, Cancer Genetics and Cytogenetics. 2003, 141: 79-82.

Researcher : Man YB

List of Research Outputs

Cheung B.M.Y., Lam T.H., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Man Y.B., Cheng C.H., Kumana C.R. and Lau C.P., Follow Up of the Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort (CP17), Seventh Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine: Journal of the Hong Kong College of Cardiology . 2003, 11 (Suppl 1).

Cheung B.M.Y., Lam T.H., Lam K.S.L., Tam S.C.F., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Man Y.B., Cheng C.H., Kumana C.R. and Lau C.P., Follow up of the Hong Kong Cardiovascular risk factor prevalence survey cohort, Hong Kong Medical Journal. 2003, 9(1) Suppl: 27.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., High blood pressure is related to obesity in Hong Kong, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., High blood pressure is related to obesity in Hong Kong, Hong Kong Medical Journal. 2003, 9(1) Suppl: 35.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Lipid profile of the Hong Kong cardiovascular risk factor prevalence study cohort, Hong Kong Medical Journal. 2003, 9(1) Suppl: 22.

Cheung B.M.Y., Man Y.B., Lam K.S.L., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Lipid profile of the Hong Kong cardiovascular risk factor prevalence survey cohort, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Obesity in the Hong Kong cardiovascular risk factor prevalence survey-2 (CRISPS2) cohort, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Cheung B.M.Y., Man Y.B., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of Diabetes Mellitus (DM) in the Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort (P16), Seventh Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine: Journal of the Hong Kong College of Cardiology . 2003, 11 (Suppl 1).

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of diabetes mellitus (DM) in the Hong Kong Cardiovascular risk factor prevalence study cohort, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Cheung B.M.Y., Man Y.B., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of diabetes mellitus (DM) in the Hong Kong Cardiovascular risk factor prevalence study cohort, Hong Kong Medical Journal. 2003, 9(1) Suppl: 19.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of obesity in the Hong Kong Cardiovascular risk factor prevalence survey-2 (CRISPS2), Hong Kong Medical Journal. 2003, 9(1) Suppl: 23.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Relationship between Hypertension and Obesity in Hong Kong, 3rd Asian-Pacific Congress of Hypertension. 2004.

Cheung B.M.Y., Leung Y.H., Wong L.Y.F., Man Y.B., Lau C.P. and Kumana C.R., Urotensin II in hypertension, Hong Kong Medical Journal. 2003, 9(1) Suppl: 24.

Man Y.B., Cheung B.M.Y., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of hypertension in the Hong Kong cardiovascular risk factor prevalence study cohort, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Researcher : Mok TMY

List of Research Outputs

Jin O., Sun L.Y., Zhou K.X., Zhang X.S., Feng X.B., Mok T.M.Y. and Lau W.C.S., Lymphocyte apoptosis and macrophage function correlation with disease activity in systemic lupus erythematosus, 7th International Congress on SLE & Related Conditions, New York. 2004.

Jin O., Sun L., Zhou K., Zhan X., Mok T.M.Y. and Lau W.C.S., Lymphocyte apoptosis, macrophage function and disease activity in systemic lupus erythematosus, Annals of the Rheumatic Diseaes, The EULAR Journal. 2003, 62(suppl I): 198.

Jin O., Chan W.K., Mok T.M.Y., Sun L.Y. and Lau W.C.S., Serum levels of osteopontin and matrix metalloproteinase-3 in systemic lupus erythematosus (SLE), 7th International Congress on SLE & Related Conditions, New York. 2004.

Mok T.M.Y., Yeung J.S.L., Jin O., Chan W.K., Lo Y. and Lau W.C.S., Anti-beta2 glycoprotein I antibodies facilitates phagocytosis of apoptotic neutrophils in patients with systemic lupus erythematosus, The Hong Kong Practitioner. 2003, 9(Suppl 1): 65.

Mok T.M.Y., Chan E.Y.T., Leung K., Lo Y., Wong R.W.S. and Lau W.C.S., Antiphospholipid antibody profiles in Chinese patients with systemic lupus erythematosus, The Hong Kong Practitioner. 2004, 2: RI-04.

Mok T.M.Y., Lao T.T.H., Collins R.J., Leung T.Y., Leung P.Y., Chan D.T.M., Wong R.W.S. and Lau W.C.S., Cervical dysplasia in patients with systemic lupus erythematosus, 7th International Congress on SLE and Related Condidtions, New York. 2004.

Mok T.M.Y., Lao T.T.H., Collins R.J., Leung T.Y., Leung P.Y., Lo Y., Chan D.T.M., Wong R.W.S. and Lau W.C.S., Cervical dysplasia in patients with systemic lupus erythematosus, The Hong Kong Practitioner. 2004, 2: RI-05.

Mok T.M.Y., Leung P.Y., Lao T.T.H., Lo Y., Chan D.T.M., Wong R.W.S. and Lau W.C.S., Clinical predictors of fetal and maternal outcome in Chinese patients with systemic lupus erythematosus, 7th International Congress on SLE and Related Conditions, New York. 2004.

Mok T.M.Y., Leung P.Y., Lao T.T.H., Chan D.T.M., Wong R.W.S. and Lau W.C.S., Clinical predictors of fetal and maternal outcome in Chinese patients with systemic lupus erythematosus, The Hong Kong Practitioner. 2004, 2: RI-053.

Mok T.M.Y., Lo Y., Chan D.T.M., Wong R.W.S. and Lau W.C.S., Efficacy of chemotherapy for tuberculosis infection in patients with systemic lupus erythematosus in an endemic area, The Hong Kong Practitioner. 2003, 9(Suppl 1): 65.

Mok T.M.Y., Yeung J.S.L., Chan W.K., Leung P.Y., Lo Y. and Lau W.C.S., Sex hormones and apoptosis and immunoglobulin production in systemic lupus erythematosus, The Hong Kong Practitioner. 2003, 9(Suppl 1): 66.

Ren Y., Tang J., Mok T.M.Y., Chan A.W., Wu A.Y.Y. and Lau W.C.S., Increased apoptotic blood neutrophils and macrophages and decreased clearance of apoptotic neutrophils in systemic lupus erythematosus, Arthritis & Rheumatism. 2003, 48(10): 2888 - 2897.

Ren Y., Tang J.L., Mok T.M.Y., Chan W.K., Wu A.Y.Y. and Lau W.C.S., Increased apoptotic neutrophils and macrophages and impaired macrophage phagocytic clearance of apoptotic neutrophils in systemic lupus erythematosus, Arthritis & Rheumatism. 2003, 48: 2888-97.

Researcher : Mok WYW

List of Research Outputs

Mok W.Y.W., Lam C.L.K., Lam B., Cheung M.T., Yam L.Y.C. and Ip M.S.M., A Chinese version of the Sleep Apnea Quality of Life Index : reliability, validity and responsiveness, Journal of Clinical Epidemiology. 2004, 57(5): 470-478.

Researcher : Ng FH

List of Research Outputs

Ng F.H., Wong B.C.Y., Wong S.Y., Chen W.H. and Chang P.C.M., Clopidogrel plus Omeprazole Compared with Aspirin plus Omeprazole for Aspirin-Induced Symptomatic Peptic Ulcers/Erosions with Low to Moderate Bleeding/Re-Bleeding Risk -- a Single-Blind, Randomized Controlled Study, Alimentary Pharmacology and Therapeutics. 2004, 19(3): 359-65.

Ng F.H., Wong S.Y., Chang P.C.M., Chen W.H., Kng N., Lanas A.I. and Wong B.C.Y., High Incidence of Clopidogrel-Associated Gastrointestinal Bleeding in Patients with Previous Peptic Ulcer Disease, Alimentary Pharmacology and Therapeutics. 2003, 18(4): 443-9.

Researcher : Ng HP

List of Research Outputs

Kung A.W.C. and Ng H.P., Evidence for intermolecular B-cell epitope spreading from TPO to Tg in a murine EAT model induced with recombinant mouse thyroperoxidase, ENDO 2004, The Endocrine Society’s 86th Annual Meeting, June 16-19, 2004 New Orleans, USA. 2004, P2-500.2.

Ng H.P., Bang J.P. and Kung A.W.C., Development of a murine model of autoimmune thyroiditis induced with homologous mouse thyroid peroxidase, Endocrinology . 2004, 145(2): 809-16.

Ng H.P. and Kung A.W.C., Promiscuous thymic and spleenic expression of thyroid peroxidase and predisposition to autoimmune thyroiditis in mouse model, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.. 2004.

Ng H.P., Banga J.P. and Kung A.W.C., Promiscuous thymic and spleenic expression of thyroid peroxidase and predisposition to autoimmune thyroiditis in mouse model, American thyroid Association 75th Annual Meeting, 16-21 September 2003, Palm Beach, USA. Thyroid . 2003, 13(7): 703.

Researcher : Ng MMT

List of Research Outputs

Hui C.K., Lai K.C., Yuen M.F., Ng M.M.T., Chan C.K., Hu H.C., Wong R.W.M., Lai C.L. and Wong B.C.Y., Does the Addition of Endoscopic Sphincterotomy to Stent Insertion Improve Drainage of the Bile Duct in Acute Suppurative Cholangitis?, Gastrointestinal Endoscopy. 2003, 58(4): 500-4.

Hui C.K., Liu C.L., Lai K.C., Chan S.C., Hu H.C., Wong R.W.M., Cheung W.W., Ng M.M.T., Yuen M.F., Chan O.O., Lo C.M., Fan S.T. and Wong B.C.Y., Outcome of emergency ERCP for acute cholangitis in patients 90 years of age and older, Alimentary Pharmacology and Therapeutics. 2004, 19(11): 1153-1158.

Hui C.K., Lai K.C., Yuen M.F., Wong R.W.M., Chan O.O., Ng M.M.T., Chan C.K., Cheung W.W., Lam S.K., Lai C.L. and Wong B.C.Y., The Role of Cholecystectomy in Reducing Recurrent Gallstone Pancreatitis, Endoscopy. 2004, 36(3): 206-11.

Researcher : Ng MYM

List of Research Outputs

Kung A.W.C., Ng M.Y.M., Lau H.L., Paterson A.D., Bulman D., Luk K.D.K. and Chan V.N.Y., Association of low bone mineral density to microsatellite marker on chromosome 16 in Southern Chinese families, 4th International Meeting on the Genetic Epidemiology of complex Traits, 4-7 April 2004, Churchill College, Cambridge, UK. 2004.

Researcher : Pang AWK

List of Research Outputs

Au W.Y., Pang A.W.K., Choy C.K.W., Chim J.C.S. and Kwong Y.L., Quantification of circulating Epstein-Barr virus (EBV) DNA in the diagnosis and monitoring of natural killer cell and EBV-positive lymphomas in immunocompetent patients, Blood. 2004, 104(1): 243-9.

Au W.Y., Lam C.C.K., Lie A.K.W., Pang A.W.K. and Kwong Y.L., T-cell large granular lymphocyte leukemia of donor origin after allogeneic bone marrow transplantation, Americal Journal of Clinical Pathology. 2003, 120: 626-30.

Au W.Y., Lie A.K.W., Chan C., Pang A.W.K., Liang R.H.S., Ma E.S.K., Choy C.K.W. and Kwong Y.L., Treatment of post-renal transplantation lymphoproliferative disease manifesting as plasmacytoma with non-myeloablative hematopoietic stem cell transplantation from the same kidney donor, American Journal of Hematology. 2003, 74: 283-6.

Pang A.W.K., Yuen M.F., Yuan H., Lai C.L. and Kwong Y.L., Real-time quantification of hepatitis B virus core-promoter and pre-core mutants during hepatitis E antigen seroconversion, Journal of Hepatology. 2004, 40: 1008-1017.

Researcher : Pang RWC

List of Research Outputs

Pang R.W.C., Yuen J.C.H., Yuen M.F., Lai C.L., Lee K.W., Man K., Poon R.T.P., Fan S.T., Wong C.M., Ng I.O.L., Kwong Y.L. and Tse E.W.C., PIN1 over-expression and β-catenin gene mutations are distinct oncogenic events in human hepatocellular carcinoma, Oncogene. 2004, 23(23): 4182-6.

Tan K.C.B., Pang R.W.C., Tiu S.C. and Lam K.S.L., Effects of treatment with Sandostatin LAR on lipoprotein metabolism in patients with acromegaly, Clinical Endocrinology. 2003, 59: 558-564.

Researcher : Pang WC

List of Research Outputs

Tan K.C.B., Tso A.W.K., Chow W.S., Ma O.C.K., Pang W.C., Tam S.C.F. and Lam K.S.L., Determinants of postprandial triglyceride and remnant-like lipoproteins in type 2 diabetes, he 4th Congress of Asian Pacific Society of Atherosclerosis and Vascular Diseases. Bali, May 2004 . 2004.

Researcher : Peng J

List of Research Outputs

Chan O.O., Peng J., Lam S.K., Hui W.M., Wong R.W.M., Yuen M.F., Kwong Y.L., Rashid A. and Wong B.C.Y., Reveral of E-Cadherin Promoter Hypermethylation Status after Helicobacter pylori Eradication, Gastroenterology. 2004, 126 (4 Suppl 2): 333.

Li G., Xia H.H.X., Chen M.H., Peng J., Gu Q., Cui J., Cho C.H., Lam S.K., Lin M.C., Berg D.E., Feng Z., Langenbach R., Kung H. and Wong B.C.Y., Cyclooxygenase-2 Gene Disruption Enhances Gastric Inflammation but Inhibits Gastric Epithelial Proliferation Induced by H. pylori Infection, Gastroenterology. 2004, 126 (4 Suppl 2): W907.

Wang J., Gu Q., Xia H.H.X., Tu S., Peng J., Yang Y., Zou B., Lin M.C., Kung H., Lam S.K. and Wong B.C.Y., JNK1 Up-Regulates the Expression of XIAP-Associated Factor 1 (XAF1) by a P53-Dependent Pathway in Gastrointestinal Cancer, Gastroenterology. 2004, 126 (4 Suppl 2): M946.

Yang Y., Lin M.C., Ching Y.P., Lam S.K., Xia H.H.X., Tu S., Zou B., Wang J., Li G., He H., Gu Q., Peng J., Kung H. and Wong B.C.Y., FHL2 As a Co-Factor of XAF1 in the Induction of Apoptosis, Gastroenterology. 2004, 126 (4 Suppl 2): S938.

Zou B., Lin M.C., Lam S.K., Tu S., Yang Y., Wang J., He H., Peng J., Kung H. and Wong B.C.Y., Hypermethylation Status Around Exon 1 of XIAP-Associated Factor 1 in Human Gastric and Colon Cancer Cell Lines, Gastroenterology. 2004, 126 (4 Suppl 2): T981.

Researcher : Rong R

List of Research Outputs

Rong R., Tao A.W.K., Xu A., Cheung G.C.N., Yeung C., Cheung B.M.Y. and Lam K.S.L., Hypoadiponectinaemia is a risk factor of the metabolic syndrome, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Rong R., Xu A., Cheung B.M.Y., Cheung G.C.N. and Lam K.S.L., Identification of three novel missense mutations of the human melanocortin-4 receptor gene in a Chinese obesity population, ENDO 2004, New Orleans, USA, 16-19 June 2004.

Tao A.W.K., Wat N.M.S., Xu A., Rong R., Cheng K.Y., Fong H.Y., Janus E.D. and Lam K.S.L., The adiponectin gene T45G polymorphism is associated with central obesity and glucose intolerance in southern Chinese, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Tso A.W.K., Rong R., Lo C.Y., Tan K.C.B., Tiu S.C., Wat N.M.S., Xu J., Villablanca A., Larsson C., Teh B.T. and Lam K.S.L., Multiple endocrine neoplasia type 1 (MEN 1): genetic and clinical analysis in Southern Chinese, Clinical Endocrinology. 2003, 59: 129-35.

Researcher : Shen J

Project Title:	Roles of caveolins in free radical generation of the hypoxia-reoxygenated neuronal cells: implication for neuronal oxidative damage of ischemia stroke
Investigator(s):	Dr. Shen J.G., Prof. Fung P.C.W.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	01/2003
Completion Date:	12/2003

Abstract:

To clarify the roles of plasma membrane caveolae and its resident proteins caveolin-1, -2 in neuronal oxidative damage during ischemia strokes; to elucidate the correlation between the expression of caveolin-1, -2, the generation of free radicals and neuronal cell death during ischemia stroke.

Project Title:	Cholesterol homeostasis and oxidative stress: implication for neuronal oxidative damage in ischemia stroke
Investigator(s):	Dr. Shen J.G., Prof. Fung P.C.W., Dr. Liu K.J.
Department:	Medicine
Source(s) of Funding:	RGC Projects (Block Grant Funded)
Start Date:	07/2003

Abstract:

To understand the roles of plasma membrane cholesterol homeostasis in neuronal oxidative damage of ischemia stroke.

Project Title:	Effects of Buyang Huanwu Decoction on neuronal regeneration after ischemic brain injury
Investigator(s):	Dr. Shen J.G., Prof. Fung P.C.W., Prof. Tong L.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	02/2004

Abstract:

To evaluate the effects of Buyang Huanwu Decoction, a classical formula of Traditional Chinese Medicine (TCM), and its major component Astragalus membranaceus on the regeneration of neurons after ischemic brain injury.

List of Research Outputs

Chan P.S., Shen J., Fung P.C.W. and Cheung R.T.F., Overproduction of nitric oxide from neuronal nitric oxide synthase during ischemia is partly mediated via activation of neuropeptide Y Y1 receptors, Neurology. 2004, 62(Suppl 5): A144.

Chan P.S., Shen J., Fung P.C.W. and Cheung R.T.F., Overproduction of nitric oxide from neuronal nitric oxide synthase during ischemia is partly mediated via activation of neuropeptide Y-Y1 receptors, 9th Medical Research Conference. 2004.

Fung P.C.W., Shen J., Xin W.J. and Zhao B.L., Ginkgo bilobia extract (EGB 761) against hypoxia-reoxygenated induced cardiomyocyte apoptosis via inhibiting NO/ONOO-pathway and adjusting bcl-2,p53 and p21/wafl/cipl expressions., Free Radical Bio Med. 2003, 33 Suppl.1: 213.

Ho K.M.T., Shen J., Fung P.C.W., Lee F.C.W. and Tam P.C., Effect of ischemia-reperfusion on nitric oxide production in the pig-bladder (Abstract), European Urology. 2003, No. 1, Supplements 2: 170.

Khan N., Shen J., Chang T...Y..., Chang C...Y..., Fung P.C.W., Grinberg O., Demidenko E. and Swartz H., Plasma membrance cholesterol: A possible barrier to intracellular oxygen in CHO cells and their mutants,, Biochemistry. 2003, 42: 23-29.

Liao C.L., Tong L. and Shen J., Effects of Buyang Huanwu decoction (BYHWT) on nitric oxide synthase activities in mouse MCAO ischemic brain, 補陽還五湯對小鼠腦缺血后NOS活性的影響, Pharmacology and Chinese Material Medicine . 中藥藥理与臨床, 2003, 19(4): 5-7.

Liao C.L., Tong L. and Shen J., Experimental Studies of Buyang Huanwu Decoction (byhwt) Against Cerebral Ischemia Injury. , 補陽還五湯抗腦缺血的實驗研究進展, Chinese Remedies & Clinics . 中國藥物与臨床, 2003, 3: 176-178.

Qu H.D., Tong L. and Shen J., Effect of buyang huanwu decoction drug serum on expression of p53 and p21 genes in cultured rat's cerebral cortical neuron after hypoxia in vitro., 補陽還五湯含藥血清對缺氧腦皮質神經細胞p53和p21基因表達的作用, Chinese Journal of Integrate Western and Traditional Chinese Medicine . 中國中西醫結合雜志, 2004, 24(2): 133-5.

Ren J., Chang C., Fung P.C.W., Shen J. and Chan F.H.Y., Free Radical EPR Spectroscopy Analysis using blind source separation, Journal of Magnetic Resonance . 2004, 166(1): 82-91.

Ren J., Shen J., Chang C., Fung P.C.W. and Chan F.H.Y., Identification of Superoxide and Hydroxy1 Radicals EPR Spectra From Complex Spectra Using Blind Source Separation Method, World Congress on Medical Physics and Biomedical Engineering. Sydney, Australia, IFBME, 2003, 4 pages.

Shen J., Lee W.S. and Fung P.C.W., Cellular cholesterol ester accumulation promotes productions of reactive oxygen species and nitric oxide and apoptotic cell death in Chinese hamster ovary (CHO) cells under oxidative stress, 9th Hong Kong Medical Research Conference. 2004, 12.

Shen J., Tong L., Liao C.L. and Fung P.C.W., Evaluation of Buyang-Huanwu Decoction (BYHWD), a traditional Chinese Medicinal Formula, against ischemic brain injury in vivo and in vitro., 9th Hong Kong Medical Research Conference . 2004, 13.

Shen J., Fung P.C.W. and Chang T.Y., Plasma membrane cholesterol homeostasis is essential for preventing oxidative damage in Chinese hamster ovary cells. , Hong Kong Medical Journal. 2003, 9(suppl.): 40.

Shen J., Lee W.S. and Fung P.C.W., Reactive oxygen species mediate intracellular cholesterol accumulation via modulating caveolin-1 expression in Chinese hamster ovary cells. , Stress, Signalling and Control. 679th Biochemical Society Meeting at University of Essex, UK, . 2003, 63.

Shen J., Lu G., Fung P.C.W. and Chu K...W..., Ultrastructural changes of mitochondria in colorectal adenocarcinoma patients, 9th Hong Kong Medical Research Conference 1. 2004.

Researcher : Shiu SWM

List of Research Outputs

Tan K.C.B., Xu A., Shiu S.W.M. and Lam K.S.L., Association between adiponectin and hepatic lipase activity, American Diabetes Association 64th Scientific Sessions, Orlando , June 2004.

Tan K.C.B., Chow W.S., Wong Y., Shiu S.W.M. and Tam S.C.F., Effect of losartan on plasma C-reative protein in type 2 diabetic patients with microalbuminuria., In: Tan KCB, Chow WS, Wong Y, Shiu SWM, Tam SCF., Diabetes Care. 2003, 25: 1254.

Researcher : Siu LLP

List of Research Outputs

Au W.Y., Lie A.K.W., Siu L.L.P., Chan C., Ooi C.G.C., Leung A.Y.H., Liang R.H.S. and Kwong Y.L., Treatment of lymphoma relapses after allogeneic hematopoietic stem cell transplantation with intensive chemotherapy followed by infusion of hematopoietic stem cell from the original donor, Annals of Hematology. 2003, 82(9): 548-551.

Researcher : Sum SM

List of Research Outputs

Yuan H., Yuen M.F., Wong D.K.H., Sum S.M., Doutreloigne J., Sablon E. and Lai C.L., Determinants for the Occurrence of Acute Exacerbation after HBeAg Seroclearance in Chinese Patients, Hepatology. 2003, 38, No. 4, Suppl. 1: 623A.

Yuen M.F., Kato T., Mizokami M., Chan O.O., Yuen J.C.H., Yuan H., Wong D.K.H., Sum S.M., Ng I.O.L., Fan S.T. and Lai C.L., Clinical outcome and virologic profiles of severe hepatitis B exacerbation due to YMDD mutations, Journal of Hepatology. 2003, 39(5): 850-855.

Yuen M.F., Wong D.K.H., Sablon E., Yuan H., Sum S.M., Hui C.K., Chan O.O., Wong B.C.Y. and Lai C.L., Hepatitis B Virus Genotypes B and C Do Not Affect The Antiviral Response To Lamivudine, Antiviral Therapy. 2003, 8: 531-534.

Yuen M.F., Wong D.K.H., Sablon E., Yuan H., Sum S.M., Hui C.K., Wong B.C.Y. and Lai C.L., Hepatitis B Virus Genotypes B and C Do Not Affect the Anti-viral Response to Lamivudine, Hepatology. 2003, 38, No. 4, Suppl. 1: 723A.

Researcher : Sun H

List of Research Outputs

Li G.R., Sun H., To J.Y.T., Tse H.F. and Lau C.P., Demonstration of calcium-activated transient outward chloride current and delayed rectifier potassium currents in Swine atrial myocytes, Journal of Molecular and Cellular Cardiology . 2004, 36: 495-504.

Researcher : Sun JZ

List of Research Outputs

Tsang K.W.T., Tipoe G.L., Sun J.Z., Mak J.C.W., Leung Y.H., Yan C.P.K., Ko K.W., Ooi C.G.C., Ho P.L., Ho J.C.M. and Lam W.K., Central microtubular ciliary defects are of clinical significance in bronchiectasis, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia. 2003, Abstract Book PP6-20: p.199.

Tsang K.W.T., Tipoe G.L., Sun J.Z., Mak J.C.W., Leung Y.H., Yan C.P.K., Ko K.W., Ooi C.G.C., Ho P.L., Ho J.C.M. and Lam W.K., Ciliary central microtubular orientation is of no clinical significance in bronchiectasis, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia. 2003, Abstract Book PP6-21: p.200.

Tsang K.W.T., Tipoe G.L., Sun J.Z., Mak J.C.W., Leung Y.H., Yan C.P.K., Ko K.W., Ooi C.G.C. and Lam W.K., Clinical significance of ciliary abnormalities in bronchiectasis, European Respiratory Journal. 2003, suppl 22(45): P559.

Tsang K.W.T., Tipoe G.L., Sun J.Z., Leung Y.H., Ho P.L., Yuen K.Y., Mak J.C.W. and Lam W.K., Helicobacter pylori exotoxin disrupts ciliary beating and ultrastructure of human airway mucosa, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia. 2003, Abstract Book PP6-22: p.201.

Wong M.P., Tipoe G.L., Sun J.Z., Mak J.C.W., Ooi C.G.C., Ip M.S.M., Chan M.M.W., Lam W.K. and Tsang K.W.T., Clinical significance of ciliary abnormalities in bronchiectasis, Annual Scientific Meeting, Hong Kong Thoracic Society & American College of Chest Physicians, 2003. Abstract pp.30.

Researcher : Tam SCF

List of Research Outputs

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., High blood pressure is related to obesity in Hong Kong, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Cheung B.M.Y., Man Y.B., Lam K.S.L., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Lipid profile of the Hong Kong cardiovascular risk factor prevalence survey cohort, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Obesity in the Hong Kong cardiovascular risk factor prevalence survey-2 (CRISPS2) cohort, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of diabetes mellitus (DM) in the Hong Kong Cardiovascular risk factor prevalence study cohort, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Cheung E.Y.N., Ho A.Y.Y., Lam K.F., Tam S.C.F. and Kung A.W.C., Bioavailable testosterone is a risk factor for osteoporotic fracture while bioavailable estradiol is a risk factor for low bone mineral density in men, ENDO 2004, The Endocrine Society’s 86th Annual Meeting, June 16-19, 2004 New Orleans, USA. 2004, P2-53.

Chow W.S., Tan K.C.B., Xu A., Ai V.H.G., Tam S.C.F. and Lam K.S.L., Hypoadiponectinemia is associated with endothelial dysfunction, 5th Annual Scientific Meeting of Hong Kong Society of Endocrinology, Metabolism and Reproduction, October 2003, Hong Kong. 2003.

Chow W.S., Tan K.C.B., Xu A., Lam C.W., Ai V.H.G., Tam S.C.F. and Lam K.S.L., Hypoadiponectinemia is associated with impaired endothelial vasomotor function, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Lee K.K., Xu A., Tan K.C.B., Wong L.C., Tiu S.C., Tam S.C.F. and Lam K.S.L., Serum adiponectin is reduced in acromegaly and normalized after correction of growth hormone excess, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Lo C.Y., Chan W.F., Kung A.W.C., Lam K.Y., Tam S.C.F. and Lam K.S.L., Surgical treatment for primary hyperparathyroidism in Hong Kong: Changes in clinical pattern over 3 decades, Archives of Surgery. 2004, 139(1): 77-82.

Mak C.M., Lam K.S.L., Tan K.C.B., Ma O.C. and Tam S.C.F., Cerebrotendinous xanthomatosis in a Hong Kong Chinese kinship with a novel splicing site mutation IVS6-1 G>T in the sterol 27 hydroxylase gene, Molecular Genetics and Metabolism. 2004, 81: 144-6.

Mak M., Lam K.S.L., Ma O.C., Tso A.W.K. and Tam S.C.F., A novel insprtion 110_111insG creating a stop codon D194x in a Chinese family with X-linked adrenoleukodystrophy, 15th Annual Scientific Meeting of Hong Kong Society of Endocrinology, Metabolism and Reproduction, October 2003, Hong Kong. 2003.

Man Y.B., Cheung B.M.Y., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of hypertension in the Hong Kong cardiovascular risk factor prevalence study cohort, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Tam S.C.F., Tan K.C.B., Wat N.M.S., Janus E.D., Lam T.H. and Lam K.S.L., C-reactive protein predicts the deterioration of glycemia in Chinese subjects with impaired glucose tolerance, 18th International Diabetes Federation Congress, Paris, August 2003.

Tan K.C.B., Chow W.S., Tam S.C.F., Bucala R. and Betteridge D.J., Association between acute phase reactants and advanced glycation end products in type 2 diabetes mellitus, Diabetes Care. 2004, 27: 223-228.

Tan K.C.B., Xu A., Chow W.S., Ai V.H.G., Tam S.C.F. and Lam K.S.L., Association between adiponectin and endothelial dysfunction, XIIIth International Symposium on Atherosclerosis, Sep 28-oct 2, 2003, Kyoto, Japan. European Atherosclerosis Society, 2003, 1P-0167.

Tan K.C.B., Wat N.M.S., Tam S.C.F., Janus E.D., Lam T.H. and Lam K.S.L., C-reactive protein predicts the deterioration of glycaemia in Chinese subjects with impaired glucose tolerance, Diabetes Care. 2003, 26: 2323-2328.

Tan K.C.B., Tso A.W.K., Chow W.S., Ma O.C.K., Pang W.C., Tam S.C.F. and Lam K.S.L., Determinants of postprandial triglyceride and remnant-like lipoproteins in type 2 diabetes, he 4th Congress of Asian Pacific Society of Atherosclerosis and Vascular Diseases. Bali, May 2004 . 2004.

Tan K.C.B., Chow W.S., Wong Y., Shiu S.W.M. and Tam S.C.F., Effect of losartan on plasma C-reative protein in type 2 diabetic patients with microalbuminuria., In: Tan KCB, Chow WS, Wong Y, Shiu SWM, Tam SCF., Diabetes Care. 2003, 25: 1254.

Tan K.C.B., Xu A., Chow W.S., Lam C.W., Ai V.H.G. and Tam S.C.F., Hypoadiponectinemia is associated with impaired endothelial vasomotor function, Journal of Clinical Endocrinology and Metabablism. 2004, 89: 765-769.

Tan K.C.B., Xu A., Chow W.S., Ai V.H.G., Tam S.C.F. and Lam K.S.L., Hypoadiponectinemia is associated with impaired endothelium-dependent vasodilatation, Journal of Endocrinology and Metabolism. 2004, 89: 765-9.

Xu J., Dan Q., Chan V.N.Y., Wat N.M.S., Tam S.C.F., Tiu S.C., Lee K.F., Siu S.C., Tsang M.W., Fung L.M., Chan K.W. and Lam K.S.L., Genetic and clinical characteristics of maturity-onset diabetes of the young in Chinese patient, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Researcher : Tan KCB

Project Title:	Inflammation and advanced glycation end products in diabetes mellitus
Investigator(s):	Dr. Tan K.C.B.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2001
Completion Date:	10/2003

Abstract:

To investigate whether there is a relationship between plasma CRP and AGEs concentrations in patients with type 2 diabetes mellitus; to investigate the direct effects of AGEs on hepatocyte CRP production; to investigate whether CRP can modulate or potentiate the adverse effects of AGEs on endothelial cells.

Project Title:	Roles of oxidative stress in inflammation and lipid peroxidation in obstructive sleep apnoea
Investigator(s):	Dr. Tan K.C.B., Dr. Chow W.S., Prof. Ip M.S.M., Dr. Lam B.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2002

Abstract:

To investigate whether oxidative stress induces inflammation and lipid peroxidation in patients with OSA and to determine whether these abnormalities can be reversed by reducing leucocyte oxidative stress using continuous positive airway pressure (CPAP) therapy.

Project Title:	Advanced glycation end products and diabetic complications
Investigator(s):	Dr. Tan K.C.B., Prof. Betteridge J.
Department:	Medicine
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	12/2002

Abstract:

Hyperglycaemia leading to the increased formation and accumulation of advanced glycation end products (AGEs) has been implicated in causing many of the complications of diabetes. In this project, the research team plan to explore the underlying mechanisms whereby AGEs may cause defective endothelium-dependent vasodilation.

Project Title:	Effects of adiponectin on endothelial cell function
Investigator(s):	Dr. Tan K.C.B., Prof. Lam K.S.L., Dr. Xu A.M.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2003

Abstract:

To investigate whether adiponectin increases NO production by inducing eNOS expression and activity; to determine whether adiponectin phosphorylates eNOS through Akt activation.

List of Research Outputs

But B., Chan C.W., Chan F., Chan K.W., Cheng A.W.F., Cheung P., Choi K.L., Chow C.B., Chow F.C.C., Eastman C., Fok T.F., Fung L.M., Gomes C., Huen K.F., Ip T.P., Kung A.W.C., Lam K.S.L., Lam Y.Y., Lao T.T.H., Lee C.Y., Lee K.F., Leung J., Leung N.K., Li D., Li J., Lo K.W., Low L.C.K., Ng K.L., Siu S.C., Tam S.C.F., Tan K.C.B., Tiu S.C., Tse H.Y., Tse W., Wong G., Wong S., Wong W., Yeung V.T.F., Young R., Yu C.M. and Yu R., Consensus statement on iodine deficiency disorders in Hong Kong, Hong Kong Medical Journal. 2003, 9: 446-453.

Cheung B.M.Y., Law C.Y., Fung P.C.W., Tsang K.W.T., Tan K.C.B., Kumana C.R. and Lau C.P., Randomised Trial of Candesartan and Enalapril (RACE) in the treatment of hypertension (P-215), In: FC Tuluney, M Orme, Sixth Congress of European Association of Clinical Pharmacology adn Therapeutics - European Collaboration: Towards Drug Development and Rational Drug Therapy . 2003, 128.

Cheung B.M.Y., Law C.Y., Fung P.C.W., Tsang K.W.T., Tan K.C.B., Kumana C.R. and Lau C.P., Randomised trial of candesartan and enalapril (RACE) in the treatment of hypertension-final results, Hong Kong Medical Journal. 2003, 9(1) Suppl: 24.

Chow W.S., So T., Tan K.C.B., Choy A., Hung V., Hui C.K., Chu D., Chan C.K. and Lam K.S.L., An evaluation of the effectiveness of a step-down clinic for diabetes in Hong Kong, 18th Congress of International Diabetes Federation, 24-29 Aug 2003, Paris, France. 2003, A103(286).

Chow W.S., Tse H.F., Tan K.C.B., Lo K.W., Lee K.F. and Lam K.S.L., Effect of intensifying glycemic control on vasomotor functions in subjects with type 1 diabetes mellitus, American Diabetes Association 64th Scientific Sessions, Orlando , June 2004.

Chow W.S., Tan K.C.B., Xu A., Ai V.H.G., Tam S.C.F. and Lam K.S.L., Hypoadiponectinemia is associated with endothelial dysfunction, 5th Annual Scientific Meeting of Hong Kong Society of Endocrinology, Metabolism and Reproduction, October 2003, Hong Kong. 2003.

Chow W.S., Tan K.C.B., Xu A., Lam C.W., Ai V.H.G., Tam S.C.F. and Lam K.S.L., Hypoadiponectinemia is associated with impaired endothelial vasomotor function, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Lam K.S.L. and Tan K.C.B., Organisation of Care: the 'at risk' person in the community, In: E Ferranini, P Zimmet, R Defronzo and H Keen, International Textbook of Diabetes Mellitus. John Wiley & Son, 2003, 3rd Edition: 1777-1784.

Lee K.K., Xu A., Tan K.C.B., Wong L.C., Tiu S.C., Tam S.C.F. and Lam K.S.L., Serum adiponectin is reduced in acromegaly and normalized after correction of growth hormone excess, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Leung G.K.K., Chow W.S., Tan K.C.B., Fan Y.W. and Lam K.S.L., Metastatic melanoma of the pituitary gland, Journal of Neurosurgery. 2003, 99(5): 913-915.

Mak C.M., Lam K.S.L., Tan K.C.B., Ma O.C. and Tam S.C.F., Cerebrotendinous xanthomatosis in a Hong Kong Chinese kinship with a novel splicing site mutation IVS6-1 G>T in the sterol 27 hydroxylase gene, Molecular Genetics and Metabolism. 2004, 81: 144-6.

Man E., Tan K.C.B., Chan K.W., Yeung L.P.K., Kwan E.Y.W., Wong W.H.S., Low L.C.K. and Cheung P.T., Positive Corrleation of Selective IGF-I Genotypes with Idiopathic Short Stature in Chinese Children, ENDO 2004, New Orleans, USA, 16-19 June 2004. P3-449.

Man E., Tan K.C.B., Chan K.W., Yeung L.P.K., Kwan E.Y.W., Wang W., Low L.C.K. and Cheung P.T., Positive correlation of selective IGF-1 genotypes with short stature in Chinese, 86th Annual Meeting of The Endocrine Society, New Orleans, June 2004.

Tam S.C.F., Tan K.C.B., Wat N.M.S., Janus E.D., Lam T.H. and Lam K.S.L., C-reactive protein predicts the deterioration of glycemia in Chinese subjects with impaired glucose tolerance, 18th International Diabetes Federation Congress, Paris, August 2003.

Tan K.C.B., ,Members of the WHO expert consultation. Appropriate body mass index for Asian populations and its implications for policy and intervention strategies, Lancet . 2004, 363: 157-163.

Tan K.C.B., Chow W.S., Tam S.C.F., Bucala R. and Betteridge D.J., Association between acute phase reactants and advanced glycation end products in type 2 diabetes mellitus, Diabetes Care. 2004, 27: 223-228.

Tan K.C.B., Xu A., Chow W.S., Ai V.H.G., Tam S.C.F. and Lam K.S.L., Association between adiponectin and endothelial dysfunction, XIIIth International Symposium on Atherosclerosis, Sep 28-oct 2, 2003, Kyoto, Japan. European Atherosclerosis Society, 2003, 1P-0167.

Tan K.C.B., Xu A., Shiu S.W.M. and Lam K.S.L., Association between adiponectin and hepatic lipase activity, American Diabetes Association 64th Scientific Sessions, Orlando , June 2004.

Tan K.C.B., Cooper M.B., Ling K.L.E., Griffin B., Shepherd J., Packard C., Hales C.N. and Betteridge D.J., Association between serum concentrations of advanced glycation end products and C-reactive protein in type 2 diabetes mellitus, 18th International Diabetes Federation Congress, Paris, August 2003.

Tan K.C.B., Wat N.M.S., Tam S.C.F., Janus E.D., Lam T.H. and Lam K.S.L., C-reactive protein predicts the deterioration of glycaemia in Chinese subjects with impaired glucose tolerance, Diabetes Care. 2003, 26: 2323-2328.

Tan K.C.B., Clinical Experience in acromegaly management in Hong Kong, International Consensus Meeting for Management of acromegaly, Shanghai, June 2004.

Tan K.C.B., Tso A.W.K., Chow W.S., Ma O.C.K., Pang W.C., Tam S.C.F. and Lam K.S.L., Determinants of postprandial triglyceride and remnant-like lipoproteins in type 2 diabetes, he 4th Congress of Asian Pacific Society of Atherosclerosis and Vascular Diseases. Bali, May 2004 . 2004.

Tan K.C.B., Dyslipidaemia, inflammation and endothelial dysfunction in diabetes mellitus, 13th International Symposium on Atherosclerosis, September 28 – October 2, 2003, Kyoto, Japan. Atherosclerosis . 2003, 4(2): 190.

Tan K.C.B., Chow W.S., Wong Y., Shiu S.W.M. and Tam S.C.F., Effect of losartan on plasma C-reative protein in type 2 diabetic patients with microalbuminuria., In: Tan KCB, Chow WS, Wong Y, Shiu SWM, Tam SCF., Diabetes Care. 2003, 25: 1254.

Tan K.C.B., Pang R.W.C., Tiu S.C. and Lam K.S.L., Effects of treatment with Sandostatin LAR on lipoprotein metabolism in patients with acromegaly, Clinical Endocrinology. 2003, 59: 558-564.

Tan K.C.B., Xu A., Chow W.S., Lam C.W., Ai V.H.G. and Tam S.C.F., Hypoadiponectinemia is associated with impaired endothelial vasomotor function, Journal of Clinical Endocrinology and Metabablism. 2004, 89: 765-769.

Tan K.C.B., Xu A., Chow W.S., Ai V.H.G., Tam S.C.F. and Lam K.S.L., Hypoadiponectinemia is associated with impaired endothelium-dependent vasodilatation, Journal of Endocrinology and Metabolism. 2004, 89: 765-9.

Tso A.W.K., Wat N.M.S., Janus E.D., Wong L.C., Tan K.C.B. and Lam K.S.L., Effect of endothelial nitric oxide synthase polymorphism (GLU298Asp) on the progression of glycaemia in Chinese subjects with impaired glucose tolerance, 15th Annual Scientific Meeting of Hong Kong Society of Endocrinology, Metabolism and Reproduction, October 2003, Hong Kong. 2003.

Tso A.W.K., Wat N.M.S., Janus E.D., Wong L.C., Tan K.C.B. and Lam K.S.L., Effect of endothelial nitric oxide synthase polymorphism (Glu298Asp) on the progression of glycaemia in Chinese subjects with impaired glucose tolerance, 18th International Diabetes Federation Congress, Paris, August 2003.

Tso A.W.K., Rong R., Lo C.Y., Tan K.C.B., Tiu S.C., Wat N.M.S., Xu J., Villablanca A., Larsson C., Teh B.T. and Lam K.S.L., Multiple endocrine neoplasia type 1 (MEN 1): genetic and clinical analysis in Southern Chinese, Clinical Endocrinology. 2003, 59: 129-35.

Researcher : Tang SCW

List of Research Outputs

Chan L.Y., Leung J.C.K., Tsang W.L., Chan D.T.M., Tang S.C.W. and Lai K.N., Activation Of Human Proximal Renal Tubular Epithelial Cells By Mediators Released From Mesangial Cells Cultured With IgA, Journal of the American Society of Nephrology. 2003, 14: 375A.

Lai K.N., Tang S.C.W., Guh J.Y., Chuang T.D., Lam M.F., Chan L.Y., Tsang W.L. and Leung J.C.K., Polymeric IgA1 from patients with IgA nephropathy upregulates transforming growth factor-beta synthesis and signal transduction in human mesangial cells via the renin-angiotensin system, Journal of American Society of Nephrology. 2003, 14: 3127-3137.

Lam M.F., Tang S.C.W. and Lai K.N., Dialysis-related amyloidosis revisited, International Journal of Artificial Organs. 2003, 26: 892-896.

Leung J.C.K., Chan L.Y., Tsang W.L., Tang S.C.W. and Lai K.N., Anti-Macrophage Migration Inhibitory Factor Reduces Transforming Growth Factor-1b Expression In Experimental IgA Nephropathy, Journal of the American Society of Nephrology. 2003, 14: 408A.

Tang S.C.W., Leung J.C.K., Tang A., Ho Y.W., Chan L.Y., Chan D.T.M. and Lai K.N., A Prospective, Randomized, Case-Controlled Study On The Efficacy Of Mycophenolate Mofetil For IgA Nephropathy Patients With Persistent Proteinuria Despite Angiotensin Blockade, Journal of the American Society of Nephrology. 2003, 14: 752A.

Tang S.C.W. and Lai K.N., Acute Hydrothorax In A Peritoneal Dialysis Patient: Long Term Efficacy Of Autologous Blood Cell Pleurodesis Associated With Small-Volume Peritoneal Exchange, Nephrology, Dialysis and Transplantation. 2003, 18: 2452.

Tang S.C.W. and Lai K.N., Acute Hydrothorax In Peritoneal Dialysis Patients: Diagnosis And Treatment Options, Nephrology, Dialysis and Transplantation. 2003, 18: 2452.

Tang S.C.W., Leung C.B., Wong K.M., Kwan T.H., Lui S.L., Tsang W.K., Mak S.K., Yu A.W. and Li P.K., Prevalence of kidney disease in Hong Kong: principal results from the Screening for Hong Kong Asymptomatic Renal Population and Evaluation (SHARE) programme., Hong Kong Journal Nephrology. 2004, 6: A1.

Tang S.C.W., Leung J.C.K., Chan L.Y., Tsang W.L., Chen X., Zhou W., Lai K.N. and Sacks S.H., Regulation of complement C3 and C4 synthesis in human peritoneal mesothelial cells by peritoneal dialysis fluid, Clinical & Experimental Immunology. 2004, 136: 85-94.

Tang S.C.W., Lui S.L., Lo C.Y., Lo W.K., Cheng I.K.P., Lai K.N. and Chan D.T.M., Spousal renal donor transplantation in Chinese subjects: a 10 year experience from a single centre, Nephrology Dialysis Transplantation. 2004, 19: 203-206.

Tang S.C.W., Cheng I.K.P., Leung V.K.S., Kuok U.I., Tang A.W.C., Ho Y.W., Lai K.N. and Chan D.T.M., Successful treatment of hepatitis C after kidney transplantation with combined interferon alpha-2b and ribavirin, Journal of Hepatology. 2003, 39: 875-878.

Tang S.C.W., Tang A.W., Tam M.K. and Ho Y.W., Use of tacrolimus in steroid- and cyclophosphamide-resistant minimal change nephrotic syndrome. , American Journal of Kidney Diseases. 2003, 42(E21): 13-15.

Researcher : Tong SM

List of Research Outputs

Wong B.C.Y., Wong R.W.M., Cheung K.L., Tong S.M., Rozen P., Young G.P., Chu K.W., Ho J.W.C., Law W.L., Tung H.M., Lai K.C., Hu H.C., Chan C.K. and Lam S.K., A Sensitive Guaiac Fecal Occult Blood Test is Less Useful than an Immunochemical Test for Colorectal Cancer Screening in a Chinese Population , Alimentary Pharmacology and Therapeutics. 2003, 18(9): 941-946.

Wong W.M., Lam S.K., Tong S.M., Cheung K.L., Tang V.S.Y., Xia H.H.X., Lai K.C., Hu H.C., Chan C.K., Yuen M.F., Chan O.O. and Wong B.C.Y., Evaluation of a Rapid Stool Antigen Test for the Diagnosis of Helicobacter pylori Infection in Chinese Patients, Chinese Journal of Digestive Diseases. 2003, 4: 132-135.

Researcher : Tsang KWT

Project Title:	Taxotere study in lung cancer
Investigator(s):	Dr. Tsang K.W.T., Dr. Ho C.M., Prof. Ip M.S.M., Prof. Lam W.K.
Department:	Medicine
Source(s) of Funding:	Rhone-Poulenc Rorer Ltd.
Start Date:	08/1998

Abstract:

Effects of treatment on non-small cell lung cancer patients' (1) disease activity, (2) survival.

Project Title:	Bronchiectasis exacerbation treatment study
Investigator(s):	Dr. Tsang K.W.T., Prof. Ip M.S.M., Prof. Lam W.K.
Department:	Medicine
Source(s) of Funding:	Bristol-Myers-Squibb (HK)
Start Date:	11/1998

Abstract:

To compare the efficacy of cefepime vs ceftazidime on exacerbations of bronchiectasis.

Project Title:	Fluticasone in bronchiectasis
Investigator(s):	Dr. Tsang K.W.T., Prof. Ip M.S.M., Prof. Lam W.K.
Department:	Medicine
Source(s) of Funding:	Glaxo Wellcome Hong Kong Ltd.
Start Date:	12/1998

Abstract:

To determine the efficacy on (1) lung function, (2) quality of life, (3) exacerbation frequency in bronchectasis.

Project Title:	Traditional Chinese medicine in the treatment of non-small cell lung cancer
Investigator(s):	Dr. Tsang K.W.T.
Department:	Medicine
Source(s) of Funding:	The Suen Chi Sun Charitable Foundation
Start Date:	08/1999

Abstract:

To study traditional Chinese medicine in the treatment of non-small cell lung cancer.

Project Title:	Could gastro-oesphageal reflux be a cause of continued airway damage in bronchiectasis?
Investigator(s):	Dr. Tsang K.W.T., Dr. Hu W.
Department:	Medicine
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	11/2002

Abstract:

The study is to determine the prevalence and severity of gastro-oesophageal reflux (GOR) in patients with bronchiectasis, the relationship of GOR with airway inflammation parameters, and identify clinical an dother parameters which predict the presence of GOR in patients with bronchiectasis with and without upper abdominal symptoms.

Project Title:	A retrospective analysis of the efficacy of various treatment regiments in short term clinical outcome for patients with Severe Acute Respiratory Syndrome (SARS)
Investigator(s):	Dr. Tsang K.W.T., Dr. Ho P.L., Prof. Lam W.K., Dr. Mak J.C.W., Dr. Mok T., Dr. Ooi C.G.C.
Department:	Medicine
Source(s) of Funding:	SARS Research Fund
Start Date:	07/2003
Completion Date:	10/2003

Abstract:

To carry out a retrospective study when applying varied dose of methylprednisolone and steroid on patients, and evaluate its impact on the planning of future clinical practice, design of controlled clinical trials, understanding of the pathogenesis in SARS, as well as prognostic importance..

Project Title:	Are matrix metalloproteinases (MMP-8, MMP-9) responsible for the continued destruction and perpetuation of inflammation in the airways of bronchiectasis?
Investigator(s):	Dr. Tsang K.W.T., Dr. Mak J.C.W., Dr. Tipoe G.L.
Department:	Medicine
Source(s) of Funding:	RGC Projects (Block Grant Funded)
Start Date:	07/2003

Abstract:

To evaluate the hypothesis, based on our preliminary findings, that airway matrix metalloproteinase (MMP)-8 and -9, released by airway neutrophils, significantly contribute to the development of continued inflammation and tissue destruction in bronchiectasis; to study the in vitro effects of these MMPs on the functional, ultrastructural and immunological aspects of airway mucosa; to assess the in vitro efficacy of various potential novel therapeutic and chemical agents on the effects of these MMPs.

List of Research Outputs

Chan M.M.W., Ait-Khaled N., White N., Tsang K.W.T. and Tan W.C., Management of chronic obstructive pulmonary disease in Asia and Africa., International Journal of Tuberculosis and Lung Disease. 2004, 8(2): 159-70.

Chan M.M.W., Lam W.K., Mak J.C.W., Ho S.P., Chan R.H.W., Tsang K.W.T., Ip M.S.M., Ho J.C.M., Wong M.P. and Tan-Un K.C., Polymorphisms of CYP and GST genes, passive smoke and lung cancer risk in Hong Kong Chinese, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-11.

Chan M.M.W., Seto W.H., Sung J.J., Lai T.S.T., Yee W., Yam L.Y.C., Tsang K.W.T., Ip M.S.M., Lam W.K. and Lai K.N., Severe Acute Respiratory Syndrome: Patients Were Epidemiologically Linked, British Medical Journal. 2003, 326: 1393.

Chan M.M.W., Ooi C.G.C., Hui D.S., Ho P.L. and Tsang K.W.T., Severe acute respiratory syndrome., International Journal of Tuberculosis and Lung Disease. 2003, 7(12): 1117-30.

Cheung B.M.Y., Hwang I.S.S., Li Y.Y., O W.S., Tsang K.W.T., Leung Y.H., Kumana C.R. and Tang F., Increased adrenomedullin expression in lungs in endotoxaemia, Journal of Endocrinology. Bristol, Society for Endocrinology, 2004, 181(2): 339-345.

Cheung B.M.Y., Law C.Y., Fung P.C.W., Tsang K.W.T., Tan K.C.B., Kumana C.R. and Lau C.P., Randomised Trial of Candesartan and Enalapril (RACE) in the treatment of hypertension (P-215), In: FC Tuluney, M Orme, Sixth Congress of European Association of Clinical Pharmacology adn Therapeutics - European Collaboration: Towards Drug Development and Rational Drug Therapy . 2003, 128.

Cheung B.M.Y., Law C.Y., Fung P.C.W., Tsang K.W.T., Tan K.C.B., Kumana C.R. and Lau C.P., Randomised trial of candesartan and enalapril (RACE) in the treatment of hypertension-final results, Hong Kong Medical Journal. 2003, 9(1) Suppl: 24.

Gu H., Ho P.L., Tsang K.W.T., Yu C.W. and Xu B., Using biofunctional magnetic nanoparticles to capture gram-negative bacteria at an ultra-low concentration , Chemical Communications. 2003, 15: 1966-7.

Ho J.C.M., Lam W.K., Yan C.P.K., Ip S., Wong M., Lam J., Wang J., Lam C.L., Lam B., Chan M.M.W., Ip M.S.M. and Tsang K.W.T., A phase II study of vinorelbine monotherapy in the treatment of advanced nob-small cell lung cancer in the elderly, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-06.

Ho J.C.M., Lam W.K., Lam B., Wong M.P. and Tsang K.W.T., Clinical outcome for lymphoepithelioma-like carcinoma of the lung cancer after chemoradiotherapy, Lung Cancer. 2003, 41 (suppl 2): S146.

Ho J.C.M., Wong R.W.M., Ooi C.G.C., Mok T.Y., Hung I.F., Ng W., Lam Y.M., Tam W.O., Wong P.C., Ho P.L., Lai C.L., Lam W.K., Lam S.K. and Tsang K.W.T., Correlation of Liver Dysfunction And Disease Activity In Patients With Severe Acute Respiratory Syndrome, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-08.

Ho J.C.M., Ooi C.G.C., Mok T.Y., Chan J.W., Hung I., Lam B., Wong P.C., Li P.C., Ho P.L., Lam W.K., Ng C.K., Ip M.S.M., Lai K.N., Chan M.M.W. and Tsang K.W.T., High-dose pulse versus nonpulse corticosteroid regimens in severe acute respiratory syndrome, American Journal of Respiratory and Critical Care Medicine. 2003, 168: 1449-1456.

Ho J.C.M., Tipoe G.L., Zheng L., Leung T.M., Tsang K.W.T., Shum D.K.Y., Lau W.C.S., Mak J.C.W., Lam W.K. and Ip M.S.M., In vitro study of regulation of IL-6 production in bronchiectasis, Respiratory Medicine. 2004, 98: 334-341.

Ho J.C.M., Ooi C.G.C., Mok T.Y.M., Ho P.L., Chan M.M.W., Ip M.S.M., Lam W.K. and Tsang K.W.T., Initial pulse or non-pulse steroid therapy in patients with deteriorating severe acute respiratory syndrome, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia,2003. Abstract book PP6-14: p.193.

Ho J.C.M., Lam W.K., Ooi C.G.C., Wong M.P., Lam J.C., Ip M.S.M. and Tsang K.W.T., Lymphoepithelioma-like carcinoma of the lung in a patient with silicosis, European Respiratory Journal . 2003, 22(2): 383-386.

Ho J.C.M., Ho S.P., Chan M.M.W., Mak J.C.W., Ip M.S.M., Wong M.P., Tsang K.W.T. and Lam W.K., Non-small cell lung cancer in Chinese is associated with disturbance in systemic antioxidants profiles , 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-03.

Ho J.C.M., Wu A.Y.Y., Ooi C.G.C., Lam B., Ho P.L., Chan M.M.W., Ip M.S.M., Lam W.K. and Tsang K.W.T., Pentaglobin as rescue therapy in patients with severe acute respiratory syndrome, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-04.

Ho J.C.M., Ooi C.G.C., Mok T.Y., Ho P.L., Chan M.M.W., Ip M.S.M., Lam W.K. and Tsang K.W.T., Pulse corticosteroid therapy in patients with severe acute respiratory syndrome, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-05.

Ho J.C.M., Ho S.P., Chan M.M.W., Ip M.S.M., Wong M.P., Tsang K.W.T. and Lam W.K., Systemic antioxidant profiles in non-small cell lung cancer in Chinese, The Journal of the Japanese Respiratory Society. 2004, 42 (suppl): 69.

Ip M.S.M., Tse H.F., Lam B., Tsang K.W.T. and Lam W.K., Endothelial function in obstructive sleep apnea and response to treatment, American Journal of Respiratory and Critical Care Medicine. 2004, 169: 348-353.

Jones B.M., Ma E.S.K., Peiris J.S.M., Wong P.C., Ho J.C.M., Lam B., Lai K.N. and Tsang K.W.T., Prolonged disturbances of in vitro cytokine production in patients with severe acute respiratory syndrome (SARS) treated with ribavirin and steroids, Clinical & Experimental Immunology. 2004, 135: 467-473.

Khong P.L., Chan G.C.F., Lee S.L., Au W.Y., Fong D.Y.T., Tsang K.W.T. and Ooi C.G.C., b-Thalassemia Major: Thin-Section CT Features and Correlation with Pulmonary Function and Iron Overload, Radiology. 2003, 229: 507-512.

Lai K.N., Tsang K.W.T., Seto W.H. and Ooi C.G.C., Clinical, Laboratory, and Radiologic Manifestation of SARS, Current Infectious Disease Reports. 2004, 6: 213-219.

Lam B., Ooi C.G.C., Peh W.C.G., Lauder I.J., Tsang K.W.T., Lam W.K. and Ip M.S.M., Computed tomographic evaluation of the role of craniofacial and upper airway morphology obstructive sleep apnea in Chinese, Respiratory Medicine. 2004, 98: 301-307.

Lam B., Ooi C.G.C., Wong M.P., Lee R., Ip M.S.M., Chan M.M.W., Lam W.K. and Tsang K.W.T., Extrapulmonary presentation of asymptomatic pulmonary lymphangioleiomyomatosis, Respirology. 2003, 8(4): 544-547.

Lam M.F., Ooi C.G.C., Lam B., Ho J.C.M., Seto W.H., Ho P.L., Wong P.C., Liang R.H.S., Lam W.K. and Tsang K.W.T., An indolent case of severe acute respiratory syndrome, American Journal of Respiratory and Critical Care Medicine. 2004, 169(1): 125-128.

Lam W.K., Ho J.C.M., Lam B. and Tsang K.W.T., Severe acute respiratory syndrome (SARS) and impacts on travel, Internal Medicine Journal of Thailand. 2003, 19: 279-286.

Lam W.K. and Tsang K.W.T., Severe acute respiratory syndrome : what lessons have been learnt?, e-Bulletin of The Royal College of Physicians of Edinburgh (www.rcpe.ac.uk/fellows/Bulletin/breaking news/bn_extra_SARS lessons.html). 2004.

Lam W.K. and Tsang K.W.T., The severe acute respiratory syndrome (SARS) outbreak - what lessons have been learnt? , Journal of the Royal College of Physicians of Edinburgh. 2004, 34: 90-93.

Leung W.C.H., Ooi C.G.C., Mak J.C.W., Leung Y.H., Leung K.M., Lam W.K., Tsang K.W.T. and Tipoe G.L., Animal model of bronchiectasis, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: A-06.

Mak J.C.W., Ho S.P., Tsang K.W.T., Ip M.S.M., Yu W.C., Yew W.W. and Chan M.M.W., Increased transforming growth factor-beta 1 (TGF-beta 1) plasma level in Chinese patients with chronic obstructive pulmonary disease (COPD), American Thoracic Society International Conference, Orlando, USA. May 2004. 169(7): A838.

Mak J.C.W., Hui W.S., Lam W.K. and Tsang K.W.T., Role of pseudomonas aeruginosa pyocyanin in mediating cytokine release in human airway epithelial cells in vitro , 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia. 2003, Abstract Book PP7-05: p.220.

Mak J.C.W., Hui W.S., Pan N.Y., Lam W.K. and Tsang K.W.T., Role of pseudomonas aeruginosa pyocyanin in mediating cytokine release in human airway epithelial cells in vitro, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-02.

Muller N.L., Ooi C.G.C., Khong P.L., Zhou L.J., Tsang K.W.T. and Nicolaou S., High-resolution CT findings of severe acute respiratory syndrome at presentation and after admission, American Journal of Roentgenology. 2004, 182: 39-44.

Ooi C.G.C., Khong P.L., Lam B., Ho J.C.M., Yiu W.C., Wong R.W.M., Wang T., Ho P.L., Wong P.C., Chan R.H., Lam W.K., Lai K.N. and Tsang K.W.T., Relationship between radiological and clinical parameters in SARS, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia, 2003. Abstract Book: OP2-01, p.73.

Ooi C.G.C., Khong P.L., Muller N.L., Zhou L.J., Ho J.C.M., Lam B., Nicolaou S. and Tsang K.W.T., Sequential HRCT findings in SARS., The 8th Asian Pacific Society of Respirology Congress.. 2003.

Ooi C.G.C., Khong P.L., Lam B., Ho J.C.M., Yiu W.C., Wong R.W.M., Wang T., Ho P.L., Chan R.H., Lam W.K., Lai K.N. and Tsang K.W.T., Severe acute respiratory syndrome : Relationship between radiological and clinical parameters, Radiology. 2003, 229: 492-499.

Ooi C.G.C., Khong P.L., Ho J.C.M., Lam B., Wong R.W.M., Yiu M.W.C., Wong P.C., Wong C.F., Lai K.N. and Tsang K.W.T., Severe acute respiratory syndrome: radiographic evaluation and clinical outcome measures, Radiology. 2003, 229: 500-506.

Ooi C.G.C., Khong P.L., Muller N.L., Yiu W.C., Zhou L.J., Ho J.C.M., Lam B., Nicolaou S. and Tsang K.W.T., Severe acute respiratory syndrome: temporal lung changes at thin-section CT in 30 patients, Radiology. 2004, 230: 836-844.

Ooi C.G.C., Tsang K.W.T., Cheung R.T.F., Khong P.L., Ho I.W.T., Ip M.S.M., Tan C.M., Ngan H., Lam W.K., Chan F.L. and Chan M.M.W., Silicosis in 76 men: qualitative and quantitative CT evaluation - clinical-radiologic correlative study., Radiology . 2003, 228(3): 816-25.

Ooi C.G.C., Khong P.L., Muller N.L., Yiu W.C., Nicolaou S. and Tsang K.W.T., Temporal HRCT pattern of lung abnormalities in severe acute respiratory syndrome (SARS), European Congress of Radiology 2004.

Ooi C.G.C., Khong P.L., Cheng R.S.Y., Tam B., Tsang F., Lee I., Lam V.S.C., Leung K.K.Y. and Tsang K.W.T., The relationship between mediastinal lymph node attenuation with parenchymal lung parameters in silicosis, International Journal of Tuberculosis and Lung Disease. 2003, 7: 1199-1206.

Tiwari A.F.Y., Chan S.S.C., Wong A., Tai J., Cheng K., Chan J. and Tsang K.W.T., Severe Acute Respiratory Syndrome (SARS) in Hong Kong: Patients' experiences, Nursing Outlook. Mosby, Inc, 2003, 51: 212-219.

Tsang K.W.T. and Tipoe G.L., Bronchiectasis: not an orphan disease in the East, Internatiional Journal of Tuberculosis and Lung Disease. 2004, 8(6): 691-702.

Tsang K.W.T. and Tipoe G.L., Bronchiectasis: not an orphan disease in the East, International Journal of Tuberculosis and Lung Disease. 2004, Jun; 8(6): 691-702.

Tsang K.W.T., Tipoe G.L., Sun J.Z., Mak J.C.W., Leung Y.H., Yan C.P.K., Ko K.W., Ooi C.G.C., Ho P.L., Ho J.C.M. and Lam W.K., Central microtubular ciliary defects are of clinical significance in bronchiectasis, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia. 2003, Abstract Book PP6-20: p.199.

Tsang K.W.T., Tipoe G.L., Sun J.Z., Mak J.C.W., Leung Y.H., Yan C.P.K., Ko K.W., Ooi C.G.C., Ho P.L., Ho J.C.M. and Lam W.K., Ciliary central microtubular orientation is of no clinical significance in bronchiectasis, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia. 2003, Abstract Book PP6-21: p.200.

Tsang K.W.T., Tipoe G.L., Sun J.Z., Mak J.C.W., Leung Y.H., Yan C.P.K., Ko K.W., Ooi C.G.C. and Lam W.K., Clinical significance of ciliary abnormalities in bronchiectasis, European Respiratory Journal. 2003, suppl 22(45): P559.

Tsang K.W.T., Ho P.L., Tan K.C., Ooi C.G.C., Ho J.C.M., Tipoe G.L., Lam W.K. and Chan M.M.W., Efficacy of 12-month treatment with inhaled corticosteroid in bronchiectasis, European Respiratory Journal. 2003, suppl 22(45): P3213.

Tsang K.W.T., Gold standards for SARS and clinical diagnostic models, Abstract Book of Hong Kong Health Authority Convention, May. 2004, 42.

Tsang K.W.T., Tipoe G.L., Sun J.Z., Leung Y.H., Ho P.L., Yuen K.Y., Mak J.C.W. and Lam W.K., Helicobacter pylori exotoxin disrupts ciliary beating and ultrastructure of human airway mucosa, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia. 2003, Abstract Book PP6-22: p.201.

Tsang K.W.T., Other immunomodulating agents for SARS , Abstract Book of Hong Kong Health Authority Convention, May. 2004, 62.

Tsang K.W.T., Rapid action on control of SARS outbreak in Hong Kong, Abstract Book of the 2nd International Congress of the Asia Pacific Society of Infection Control March 2004 Singapore. 2004, 42.

Tsang K.W.T. and Zhong N.S., Severe acute respiratory syndrome - pharmacotherapy, Respirology. 2003, suppl 1: S25-30.

Tsang K.W.T. and Seto W.H., Severe acute respiratory syndrome - scientific and anecdotal evidence for drug treatment, Current Opinion in Investigational Drugs. 2004, 5(2): 179-185.

Tsang K.W.T., Severe acute respiratory syndrome – clinical diagnosis and management , The International Journal of Tuberculosis and Lung Disease. 2003, 7 (11) suppl 2: S113.

Tsang K.W.T., Severe acute respiratory syndrome – clinical management, Abstract Book of the Second SARS Meeting of the Chinese Medical Association, Beijing, 8-12 September. 2003, 106-111.

Tsang K.W.T., Mok T.Y., Wong P.C. and Ooi C.G.C., Severe acute respiratory syndrome – diagnosis and management for the Asian Pacific setting , Respirology. 2003, Sep; 8(3): 259-265.

Wong M.P., Tipoe G.L., Sun J.Z., Mak J.C.W., Ooi C.G.C., Ip M.S.M., Chan M.M.W., Lam W.K. and Tsang K.W.T., Clinical significance of ciliary abnormalities in bronchiectasis, Annual Scientific Meeting, Hong Kong Thoracic Society & American College of Chest Physicians, 2003. Abstract pp.30.

Wong W.M., Ho J.C.M., Hung I.F., Ng W., Lam Y.M., Tam W.O., Wong B.C.Y., Wong P.C., Lai C.L., Lam W.K., Lam S.K., Tsang K.W.T., Ooi C.G.C., Ho P.L., Mok T. and Chan J., Temporal Patterns of Hepatic Dysfunction and Disease Severity in Patients with SARS, Journal of the American Medical Association Southeast Asia (JAMA). 2003, 290(20): 2663-2665.

Wu A.Y.Y., Ooi C.G.C., Lam B., Mok T.Y.M., Ho P.L., Chan M.M.W., Ip M.S.M., Lam W.K. and Tsang K.W.T., The use of pentaglobin in patients with deteriorating severe acute respiratory syndrome, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia . 2003, Abstract Book PP6-15: p.194.

Researcher : Tsang RCW

List of Research Outputs

Chan D.T.M., Tsang R.C.W., Leung J.K.H. and Yung S.S.Y., Modulation of hyaluronan synthesis in human mesangial cells after stimulation with Anti-DNA antibodies from patients with lupus nephritis, Journal of American Society of Nephrology. 2003, 14: 594A.

Yung S.S.Y., Chen X., Tsang R.C.W., Zhang Q. and Chan D.T.M., Reduction of perlecan synthesis and induction of TGF-beta 1 in human peritoneal mesothelial cells due to high glucose concentration - implication in peritoneal dialysis, Journal of American Society of Nephrology. 2004, May 15 (5): 1178-1188.

Researcher : Tsang TKL

List of Research Outputs

Yip J.T.H., Lee T.M.C., Ho S.L., Tsang T.K.L. and Li L.S.W., Emotion recognition in patients with idiopathic Parkinson's disease., Movement Disorders. New York, USA, John-Wiley & Sons, Inc, 2003, 18(10): 1115-1122.

Researcher : Tsang WL

List of Research Outputs

Chan L.Y., Leung J.C.K., Tsang W.L., Chan D.T.M., Tang S.C.W. and Lai K.N., Activation Of Human Proximal Renal Tubular Epithelial Cells By Mediators Released From Mesangial Cells Cultured With IgA, Journal of the American Society of Nephrology. 2003, 14: 375A.

Lai K.N., Tang S.C.W., Guh J.Y., Chuang T.D., Lam M.F., Chan L.Y., Tsang W.L. and Leung J.C.K., Polymeric IgA1 from patients with IgA nephropathy upregulates transforming growth factor-beta synthesis and signal transduction in human mesangial cells via the renin-angiotensin system, Journal of American Society of Nephrology. 2003, 14: 3127-3137.

Leung J.C.K., Chan L.Y., Tsang W.L., Tang S.C.W. and Lai K.N., Anti-Macrophage Migration Inhibitory Factor Reduces Transforming Growth Factor-1b Expression In Experimental IgA Nephropathy, Journal of the American Society of Nephrology. 2003, 14: 408A.

Tang S.C.W., Leung J.C.K., Chan L.Y., Tsang W.L., Chen X., Zhou W., Lai K.N. and Sacks S.H., Regulation of complement C3 and C4 synthesis in human peritoneal mesothelial cells by peritoneal dialysis fluid, Clinical & Experimental Immunology. 2004, 136: 85-94.

Researcher : Tse EWC

Project Title:	Molecular mechanism of arsenic trioxide transport in acute promyelocytic leukaemia cells
Investigator(s):	Dr. Tse E.W.C., Prof. Kwong Y.L.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2002

Abstract:

To investigate the mechanism underlying arsenic trioxide sensitivity in acute promyelocytic leukaemia (APL); to investigate the possible role of aquaporin-9 (AQP9) in mediating the uptake of arsenic trioxide in APL and other haematological malignancies; to examine the regulation of aquaporin-9 expression in myeloid cells.

Project Title:	The role of peptidy-proply1-isomerase PIN1 in the pathogenesis of hepatocellular carcinoma
Investigator(s):	Dr. Tse E.W.C., Prof. Kwong Y.L.
Department:	Medicine
Source(s) of Funding:	RGC Projects (Block Grant Funded)
Start Date:	07/2003

Abstract:

To examine the expression of PIN1 in HCC both at the RNA and the protein levels as compared with that in paired non-cancerous liver tissue, using semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR), immunohistochemistry and Western blot analysis; to document PINI as an oncogene involved in the development of HCC by a transgenic mouse model.

Project Title:	The role of LIM-only protein, LM04, in the pathogenesis of sporadic ovarian cancer in Chinese
Investigator(s):	Dr. Tse E.W.C., Prof. Kwong Y.L.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2003

Abstract:

To assess the level of expression of LMO4 in sporadic ovarian cancer; to determine correlation between LMO4 expression and BRCA1 mutations in sporadic ovarian cancer; to determine correlation between LMO4 expression and clinical behaviour of sporadic ovarian cancer.

List of Research Outputs

Ma E.S.K., Au W.Y., Lie A.K.W., Ng I.O.L., Leung A.Y.H., Tse E.W.C., Liang R.H.S., Lau G. and Kwong Y.L., Liver graft-versus-host disease after donor lymphocyte infusion for relapses of hematologic malignancies post allogeneic hematopoietic stem cell transplantation, Bone Marrow Transplantation. 2004, 34: 57-61.

Ma S.Y., Au W.Y., Chim J.C.S., Lie A.K.W., Lam C.C.K., Tse E.W.C., Leung A.Y.H., Liang R.H.S. and Kwong Y.L., Fludarabine, mitoxantrone and dexamethasone in the treatment of indolent B-and T-cell lymphoid malignancies Chinese patients, British Journal of Haematology. 2004, 124: 754-761.

Pang R.W.C., Yuen J.C.H., Yuen M.F., Lai C.L., Lee K.W., Man K., Poon R.T.P., Fan S.T., Wong C.M., Ng I.O.L., Kwong Y.L. and Tse E.W.C., PIN1 over-expression and β-catenin gene mutations are distinct oncogenic events in human hepatocellular carcinoma, Oncogene. 2004, 23(23): 4182-6.

Tse E.W.C., Smith A.J.H., Hunt S., Lavenir I., Foster A., Warren A.J., Grutz G., Foroni L., Carlton M.B.L., Colledge W.H., Boehm T. and Rabbitts T.H., Null mutations of the Lmo4 gene or a combined null mutation of the Lmo1/ Lmo3 genes causes perinatal lethality, and Lmo4 controls neural tube development in mice, Molecular and Cellular Biochemistry. 2004, 24(5): 2063-73.

Yuen M.F., Wong D.K.H., Sablon E., Tse E.W.C., Ng I.O.L., Yuan H., Siu C.W., Sander T.J., Bourne E.J., Hall J.G., Condreay L.D. and Lai C.L., HBsAg seroclearance in chronic hepatitis B in the Chinese: Virological, histological, and clinical aspects, Hepatology. 2004, 39(6): 1694-1701.

Researcher : Tse EYY

Project Title:	Medical care of Hong Kong doctors and their families
Investigator(s):	Dr. Tse E.Y.Y., Dr. Chao D.V.K., Dr. Lam T.P., Dr. Li D.K.T.
Department:	Family Medicine Unit of the Department of Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2002
Completion Date:	10/2003

Abstract:

To study the use of medical care by Hong Kong doctors and their families.

List of Research Outputs

Tse E.Y.Y., Are we comfortable talking about sex? (Editorial), The Hong Kong Practitioner . 2003, 25(10): 465-466.

Tse E.Y.Y., Editorial Board Member (2003 - 2004), International Medical Journal. 2004.

Tse E.Y.Y., Editorial Board Member (2003 - 2004), The Hong Kong Practitioner. 2004.

Researcher : Tse HF

Project Title:	Prevention of cardiomyocyte apoptosis and myocardial fibrosis by neovascularization of ischemic myocardium by autologous bone marrow cells transplantation
Investigator(s):	Dr. Tse H.F., Prof. Kwong Y.L., Prof. Lau C.P., Dr. Nicholls J.M.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2001
Completion Date:	10/2003

Abstract:

To evaluate the effect of inducing neovascularization by using bone marrow stem cells on cardiomyocyte apoptosis, collagen deposition and myocardial function, in animal model of chronic myocardial ischemia.

Project Title:	Neovascularization of ischemic myocardium by autologous bone marrow cells transplantation
Investigator(s):	Dr. Tse H.F., Prof. Kwong Y.L., Prof. Lau C.P., Dr. Nicholls J.M.
Department:	Medicine
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	09/2002

Abstract:

The aim of this study is to compare the effect of bone marrow endothelial progenitor cells versus bone marrow mononuclear cells (MNCs) transplantation on neovascularization, cardiomyocyte apoptosis, collagen deposition and myocardial function in an animal model of chronic myocardial ischemia. The results of this study will provide important information regarding the optimal use and the basic mechanisms of autologous bone marrow transplantation for enhancement of neovascularization and improving heart function in patients with "end-stage" IHD.

Project Title:	Embryonic stem cell transplantation as a novel therapy for post-infarct left ventricular remodeling
Investigator(s):	Dr. Tse H.F., Prof. Cheah K.S.E., Prof. Lau C.P., Dr. Zhang J.C.J.L.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	10/2002

Abstract:

To establish a mouse model of myocardial infarction; to establish the system for measuring hemodynamic changes associated with heart failure in mice; to follow the fate of undifferentiated embryonic stem cell transplanted into an infarcted heart.

Project Title:	Cellular cardiomyoplasty using embryonic stem cell transplantation as a novel therapy for myocardial repair
Investigator(s):	Dr. Tse H.F., Prof. Lau C.P., Dr. Li G.R., Dr. Zhang J.C.J.L.
Department:	Medicine
Source(s) of Funding:	RGC Projects (Block Grant Funded)
Start Date:	07/2003

Abstract:

To use a murine model of myocardial infarction (MI) to address whether differentiation status of embryonic stem (ES) cells is important in salvaging heart function in chronic heart failure, and to determine the optimal timing of ES cell transplantation as a novel therapy after MI.

Project Title:	Comparative evaluation of platelet and coagulation activation between transvenous cryoablation and radiofrequency ablation for pulmonary vien isolation in patients with atrial fibrillation
Investigator(s):	Dr. Tse H.F., Prof. Kwong Y.L., Prof. Lau C.P.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	11/2003

Abstract:

To compare the potential thrombogenic risk of transvenous cryoablation versus conventional radiofrequency energy during pulmonary vein (PV) ablation procedure for treatment of atrial fibrillation (AF).

Project Title:	Direct intramyocardial implantation of autologous bone marrow cells for enhancement of neovascularization in patients with "End-Staged" coronary artery disease
Investigator(s):	Dr. Tse H.F., Prof. Kwong Y.L., Prof. Lau C.P.
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation Grant
Start Date:	01/2004

Abstract:

To determine the safety and efficacy of direct intramyocardial delivery of bone marrow cells using electromechanical guided injection; to investigate the angiogenic ability of implanting autologous bone marrow cells in patients with end-stage coronary artery disease.

List of Research Outputs

Barold S.S., Lau C.P., Tse H.F. and Hess M., Shortening of the Sensed AV Delay of a Dual Chamber Pacemaker During Normal Sinus Rhythm., J Interv Card Electrophysiol. 2003, 9: 29-34.

Chen W.H., Tse H.F., Lau C.P., Lee P.Y. and Ng W., Aspirin resistance is associated with a high incidence of myonecrosis after non-urgent percutaneous coronary intervention despite clopidogrel pretreatment, J Am Coll Cardiol . 2004, 43(6): 1122-6.

Chow W.S., Tse H.F., Tan K.C.B., Lo K.W., Lee K.F. and Lam K.S.L., Effect of intensifying glycemic control on vasomotor functions in subjects with type 1 diabetes mellitus, American Diabetes Association 64th Scientific Sessions, Orlando , June 2004.

Du X., Gao Z., Lau C.P., Chiu S.W., Tse H.F., Baumgarten C.M. and Li G.R., Differential effects of tyrosine kinase inhibitors on volume-sensitive chloride current in human atrial myocytes: evidence for dual regulation by Src and EGFR kinases, Journal of General Physiology. 2004, 123: 427-39.

Ho H.H., Lee K.L.F., Lau C.P. and Tse H.F., Clinical characteristics of and long-term outcome in Chinese patients with hypertrophic cardiomyopathy , American Journal of Medicine. 2004, 116(1): 19-23.

Ip M.S.M., Tse H.F., Lam B., Tsang K.W.T. and Lam W.K., Endothelial function in obstructive sleep apnea and response to treatment, American Journal of Respiratory and Critical Care Medicine. 2004, 169: 348-353.

Kwok K.M., Lee K.L.F., Lau C.P. and Tse H.F., Sudden cardiac death: prevention and treatment , Hong Kong Medical Journal. 2003, 9(5): 357-62.

Lau C.P., Lam Y.M., Lee K.L.F., Tse H.F., Siu D., Fan K. and Yung C., A rapid ultrasonic cardiac output monitor method for optimization of atrioventricular interval in cardiac resynchronization, Heart Rhythm 2004. 1: S279.

Lau C.P., Tse H.F., Lee K.L.F., Barold S., Chan H.W., Fan K., Chau E. and Yu C.M., Advances in devices for cardiac resynchronization in heart failure., Journal of Cardiovascular Electrophysiology. 2003, 9(2): 167-81.

Lau C.P., Tse H.F., Lee K.L.F. and Barold S.S., Unusual indication for cardiac pacing. Barold SS, Mugica J(eds). , In: The Fifth Decade of Cardiac Pacing. Armonk NY. Futura Publishing Co, Inc, 2004, 2004: 32-43.

Li G.R., Sun H., To J.Y.T., Tse H.F. and Lau C.P., Demonstration of calcium-activated transient outward chloride current and delayed rectifier potassium currents in Swine atrial myocytes, Journal of Molecular and Cellular Cardiology . 2004, 36: 495-504.

Siu C.W., Lau C.P. and Tse H.F., Prevention of atrial fibrillation recurrence by statin therapy in patients with lone atrial fibrillation after successful cardioversion, American Journal of Cardiology. 2003, 92(11): 1343-5.

Szapiro D., Ghaye B., Timmermans C., Dondelinger R.F., Ayers G., Tse H.F., Ayers G. and Rodriguez L.M., Computed tomography guided evaluation of pulmonary vein anatomy following percutaneous cryoablation: 12-month results, J Am Coll Cardiol 2004. 43: 145A.

Tse H.F., Lee K.L.F., Wan S.H., Yu Y., Walter H., Pastore J., Pastore J., Zhu Q., Kenknight B. and Spinella J., Area of left ventricualr regional conduction delay and preserved contractility predict response to cardiac resynchronization therapy, J am Coll Cardiol 2004. 43: 130A.

Tse H.F., Lau C.P. and Lee P.Y., Bone Marrow Cell Transplantation for Myocardial Regeneration and Therapeutic Angiogenesis, In: Angiogenesis and Direct Myocardial Revascularization. Totowa, NJ: Human Press Inc, 2004(in press). Humana Press Inc, 2004, 2004.

Tse H.F. and Lau C.P., Clinical Predictors and Time Course of Arrhythmia Recurrence in Patients with Early Reinitiation of Atrial Fibrillation After Successful Internal Cardioversion., Pacing Clin Electrophysiol.. 2003, 26 (9): 1809-1814.

Tse H.F. and Yiu K., Deep vein thrombosis demonstrated by contrast enhanced helical computer tomorgraphic venography, Heart. 2004, 90(3): 251.

Tse H.F., Siu C...W..., Ripley K...L. and Lau C.P., Determinants of lesion dimension during catheter cryoablation: effects of tip electrode temperature and size, Heart Rhythm 2004. 1: S111.

Tse H.F. and Lau C.P., Does sinus rhythm beget sinus rhythm? Effects of prompt cardioversion the frequency and persistence of recurrent atrial fibrillation, Cardiac Electrophysiology Review. 2003, 7(4): 359-65.

Tse H.F., Yu K.M.C., Paul V.E., Boriani G., Schuchert A., Del Ojo J.L., Malinowski K., Blanc J.J. and Lau C.P., Effect of left ventricular function on long-term left ventricular pacing and sensing threshold., J Interv Card Electrophysiol. 2003, 9 (1): 21-4.

Tse H.F. and Lau C.P., Future prospects for implantable devices for atrial defibrillation, Cardiology Clinics. 2004, 22(1): 87-100.

Tse H.F., Thambar S., Kwong Y.L., Chen W.H., Lau C.P., Chan J.K.F., Lo G., Lai C.L. and Bellan G., Long-Term clinical outcome of catheter-based intramyocardial autologous bone marrow cells implanation in patients with end-stage coronary artery disease, J Am Coll Cardiol. 2004, 43: 39A.

Tse H.F., Public health education column- coronary artery disease, Metro Daily. 2003.

Tse H.F., Reek S., Timmermans C., Lee K.L.F., Geller J.C., Rodriguez L.M., Ghaye B., Ayers G.M., Crijns H.J., Klein H.U. and Lau C.P., Pulmonary vein isolation using transvenous catheter cryoablation for treatment of atrial fibrillation without risk of pulmonary vein stenosis., J Am Coll Cardiol.. 2003, 42 (4): 752-8.

Tse H.F. and Lau C.P., Recurrence of atrial fibrillation after pulmonary vein isolation., J Cardiovasc Electrophysiol.. 2003, 14 (7): 691-2.

Tse H.F. and Lau C.P., Reply to the Editor, Journal of Cardiovascular Electrophysiology. 2003, 14(8): 899 -900.

Tse H.F., Kwong Y.L., Chan J.K.F., Lo R., Ho C.L., Yeung D.W. and Lau C.P., Therapeutic angiogenesis of human ischemic myocardium by catheter-based intramyocardial autologous bone marrow cell implantation, Lancet. 2003, 361: 47-9.

Xu W...C..., Tse H.F., Chan F.H.Y., Fung P.C.W. and Lau C.P., U.S. Patent, "A bayesian discriminator for rapidly detecting arrhythmias", 2003.

Researcher : Tsoi TH

List of Research Outputs

Bonovich D., Tsoi T.H. and Cheung R.T.F., Workshop VI: NIHSS training and certification, Hong Kong Stroke Symposium & Workshop. 2003.

Researcher : Tu S

List of Research Outputs

Tu S., Chan O.O., Lin M.C., Jiang X., Lam S.K., Kung H. and Wong B.C.Y., Livin, a Novel Member of Inhibitor of Apoptosis, Is Marker of Poor Prognosis in Gastric Cancer, Gastroenterology. 2004, 126 (4 Suppl 2): T1256.

Tu S., Jiang X., Lin M.C., Cui J., Yang Y., Lum C.T., Zou B., Zhu Y.B., Jiang S.H., Wong W.M., Chan O.O., Yuen M.F., Lam S.K., Kung H. and Wong B.C.Y., Suppression of Survivin Expression Inhibits in vivo Tumorigenicity and Angiogenesis in Gastric Cancer, Cancer Research. 2003, 63(22): 7724-7732.

Wang J., Gu Q., Xia H.H.X., Tu S., Peng J., Yang Y., Zou B., Lin M.C., Kung H., Lam S.K. and Wong B.C.Y., JNK1 Up-Regulates the Expression of XIAP-Associated Factor 1 (XAF1) by a P53-Dependent Pathway in Gastrointestinal Cancer, Gastroenterology. 2004, 126 (4 Suppl 2): M946.

Wong B.C.Y., Tu S., Kung H. and Lin M.C., A novel cocktail therapy for colon cancer: Combination of Adeno-associated virus (AAV) based survivin mutant gene therapy with chemotherapy, US Provisional patent filed June 2004. 2004.

Wong B.C.Y., Jiang X., Lin M.C., Tu S., Cui J., Jiang S.H., Wong R.W.M., Yuen M.F., Lam S.K. and Kung H., Cyclooxygenase-2 Inhibitor (SC-236) Suppresses Activator Protein-1 through c-Jun NH2-Terminal Kinase, Gastroenterology. 2004, 126: 136-147.

Yang Y., Lin M.C., Ching Y.P., Lam S.K., Xia H.H.X., Tu S., Zou B., Wang J., Li G., He H., Gu Q., Peng J., Kung H. and Wong B.C.Y., FHL2 As a Co-Factor of XAF1 in the Induction of Apoptosis, Gastroenterology. 2004, 126 (4 Suppl 2): S938.

Zou B., Lin M.C., Lam S.K., Tu S., Yang Y., Wang J., He H., Peng J., Kung H. and Wong B.C.Y., Hypermethylation Status Around Exon 1 of XIAP-Associated Factor 1 in Human Gastric and Colon Cancer Cell Lines, Gastroenterology. 2004, 126 (4 Suppl 2): T981.

Researcher : Wang J

List of Research Outputs

Wang J., Gu Q., Xia H.H.X., Tu S., Peng J., Yang Y., Zou B., Lin M.C., Kung H., Lam S.K. and Wong B.C.Y., JNK1 Up-Regulates the Expression of XIAP-Associated Factor 1 (XAF1) by a P53-Dependent Pathway in Gastrointestinal Cancer, Gastroenterology. 2004, 126 (4 Suppl 2): M946.

Yang Y., Lin M.C., Ching Y.P., Lam S.K., Xia H.H.X., Tu S., Zou B., Wang J., Li G., He H., Gu Q., Peng J., Kung H. and Wong B.C.Y., FHL2 As a Co-Factor of XAF1 in the Induction of Apoptosis, Gastroenterology. 2004, 126 (4 Suppl 2): S938.

Zou B., Lin M.C., Lam S.K., Tu S., Yang Y., Wang J., He H., Peng J., Kung H. and Wong B.C.Y., Hypermethylation Status Around Exon 1 of XIAP-Associated Factor 1 in Human Gastric and Colon Cancer Cell Lines, Gastroenterology. 2004, 126 (4 Suppl 2): T981.

Researcher : Wang W

List of Research Outputs

Wang W., Huang J., Zheng G., Lam S.K., Karlberg J.P.E. and Wong B.C.Y., Non-Steroidal Anti-Inflammatory Drug Use and the Risk of Gastric Cancer: A Systematic Review and Meta-Analysis, Journal of the National Cancer Institute. 2003, 95(23): 1784-1791.

Wong W.M., Gu Q., Wang W., Fung F.M.Y., Berg D.E., Lai K.C., Xia H.H.X., Hu H.C., Chan C.K., Chan O.O., Yuen M.F., Hui C.K., Lam S.K. and Wong B.C.Y., Effects of Primary Metronidazole and Clarithromycin Resistance to Helicobacter pylori on Omeprazole, Metronidazole, and Clarithromycin Triple-Therapy Regimen in a Region with High Rates of Metronidazole Resistance, Clinical Infectious Diseases. 2003, 37(7): 882-9.

Researcher : Wang Y (Dr Wang Yan)

List of Research Outputs

Choi K.L., Wang Y., Tse C.A., Lam K.S.L. and Cooper G.J.S., Proteomic analysis of adipocyte differentiation: Evidence that a2 macroglobulin is involved in the adipose conversion of 3T3 L1 preadipocytes, Proteomics Journal. 2004, 4: 1840-8.

Researcher : Wang Y (Ms Wang Yan)

List of Research Outputs

Wang Y., Du Y., Leung J.C.K., Maxwell P., Lai K.N. and Li Y., Megsin 2093TT Genotype Is Associated With A Protective Role In Iga Nephropathy, Journal of the American Society of Nephrology. 2003, 14: 104A.

Researcher : Wat NMS

List of Research Outputs

Chan J.C., Wat N.M.S., So W.Y., Lam K.S.L., Chau C.T., Wong K.S., Morad Z., Dickson T.Z., Hille D., Zhang Z., Cooper M.E., Shahinfar S., Brenner B.M. and Kurokawa K., Rennin angiotensin aldosterone system blockade and renal disease in patients with type 2 diabetes: an Asian perspective from the RENAAL study, Diabetes Care. 2004, 27: 874-9.

Cheung B.M.Y., Lam T.H., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Man Y.B., Cheng C.H., Kumana C.R. and Lau C.P., Follow Up of the Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort (CP17), Seventh Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine: Journal of the Hong Kong College of Cardiology . 2003, 11 (Suppl 1).

Cheung B.M.Y., Lam T.H., Lam K.S.L., Tam S.C.F., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Man Y.B., Cheng C.H., Kumana C.R. and Lau C.P., Follow up of the Hong Kong Cardiovascular risk factor prevalence survey cohort, Hong Kong Medical Journal. 2003, 9(1) Suppl: 27.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., High blood pressure is related to obesity in Hong Kong, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., High blood pressure is related to obesity in Hong Kong, Hong Kong Medical Journal. 2003, 9(1) Suppl: 35.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Lipid profile of the Hong Kong cardiovascular risk factor prevalence study cohort, Hong Kong Medical Journal. 2003, 9(1) Suppl: 22.

Cheung B.M.Y., Man Y.B., Lam K.S.L., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Lipid profile of the Hong Kong cardiovascular risk factor prevalence survey cohort, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Obesity in the Hong Kong cardiovascular risk factor prevalence survey-2 (CRISPS2) cohort, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Cheung B.M.Y., Man Y.B., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of Diabetes Mellitus (DM) in the Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort (P16), Seventh Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine: Journal of the Hong Kong College of Cardiology . 2003, 11 (Suppl 1).

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of diabetes mellitus (DM) in the Hong Kong Cardiovascular risk factor prevalence study cohort, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Cheung B.M.Y., Man Y.B., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of diabetes mellitus (DM) in the Hong Kong Cardiovascular risk factor prevalence study cohort, Hong Kong Medical Journal. 2003, 9(1) Suppl: 19.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of obesity in the Hong Kong Cardiovascular risk factor prevalence survey-2 (CRISPS2), Hong Kong Medical Journal. 2003, 9(1) Suppl: 23.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Relationship between Hypertension and Obesity in Hong Kong, 3rd Asian-Pacific Congress of Hypertension. 2004.

Lam K.S.L., Xu A., Wat N.M.S., Tso A.W.K. and Ip M.S.M., Obesity as the key player in the Metabolic Syndrome, 13th International Symposium on Atherosclerosis, September 28 – October 2, 2003, Kyoto, Japan.. 2003.

Lam K.S.L., Xu A., Wat N.M.S., Tso A.W.K. and Ip M.S.M., Obesity as the key player in the metabolic syndrome, International Congress Series. 2004, 1262: 542-5.

Lam K.S.L., Wat N.M.S., Chow W.S., Tso A.W.K., Thomas G.N. and Lam T.H., The Metabolic Syndrome: clinical implications and managements, Journal of the HK College of Cardiology . 2003, 11(Suppl 2): B39-42.

Lo C.Y., Wat N.M.S., Lam K.Y., Tiu S.C., Chan J.K.Y. and Lam K.S.L., Multiple endocrine neoplasia type 2 in Chinese families, Clinical Endocrinology. 2003, 58: 528.

Man Y.B., Cheung B.M.Y., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S.C.F., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of hypertension in the Hong Kong cardiovascular risk factor prevalence study cohort, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Tam S.C.F., Tan K.C.B., Wat N.M.S., Janus E.D., Lam T.H. and Lam K.S.L., C-reactive protein predicts the deterioration of glycemia in Chinese subjects with impaired glucose tolerance, 18th International Diabetes Federation Congress, Paris, August 2003.

Tan K.C.B., Wat N.M.S., Tam S.C.F., Janus E.D., Lam T.H. and Lam K.S.L., C-reactive protein predicts the deterioration of glycaemia in Chinese subjects with impaired glucose tolerance, Diabetes Care. 2003, 26: 2323-2328.

Tao A.W.K., Wat N.M.S., Xu A., Rong R., Cheng K.Y., Fong H.Y., Janus E.D. and Lam K.S.L., The adiponectin gene T45G polymorphism is associated with central obesity and glucose intolerance in southern Chinese, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Tso A.W.K., Wat N.M.S., Janus E.D., Wong L.C., Tan K.C.B. and Lam K.S.L., Effect of endothelial nitric oxide synthase polymorphism (GLU298Asp) on the progression of glycaemia in Chinese subjects with impaired glucose tolerance, 15th Annual Scientific Meeting of Hong Kong Society of Endocrinology, Metabolism and Reproduction, October 2003, Hong Kong. 2003.

Tso A.W.K., Wat N.M.S., Janus E.D., Wong L.C., Tan K.C.B. and Lam K.S.L., Effect of endothelial nitric oxide synthase polymorphism (Glu298Asp) on the progression of glycaemia in Chinese subjects with impaired glucose tolerance, 18th International Diabetes Federation Congress, Paris, August 2003.

Tso A.W.K., Rong R., Lo C.Y., Tan K.C.B., Tiu S.C., Wat N.M.S., Xu J., Villablanca A., Larsson C., Teh B.T. and Lam K.S.L., Multiple endocrine neoplasia type 1 (MEN 1): genetic and clinical analysis in Southern Chinese, Clinical Endocrinology. 2003, 59: 129-35.

Xu J., Dan Q., Chan V.N.Y., Wat N.M.S., Tam S.C.F., Tiu S.C., Lee K.F., Siu S.C., Tsang M.W., Fung L.M., Chan K.W. and Lam K.S.L., Genetic and clinical characteristics of maturity-onset diabetes of the young in Chinese patient, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Researcher : Wong ASY

List of Research Outputs

Chim J.C.S., Wong A.S.Y. and Liang R.H.S., Aberrant gene promoter methylation in acute promyelocytic leukaemia: profile and prognostic significance, British Journal of Haematology. 2003, 122(4): 571-578.

Chim J.C.S., Wong A.S.Y. and Kwong Y.L., Aberrant methylation in acute promyelocytic leukemia: profile and prognostic significance, British Journal of Haematology. 2003, 122: 571-578.

Chim J.C.S., Wong A.S.Y. and Kwong Y.L., Absence of p300 gene promoter methylation in acute leukemia, Cancer Genetics and Cytogenetics. 2004, 150: 164-7.

Chim J.C.S., Wong A.S.Y. and Kwong Y.L., Epigenetic dysregulation of the Jak/STAT pathway by frequent aberrant methylation of SHP1 but not SOCS1 in acute leukaemias, Annals of Hematology. 2004, 83(8): 527-32.

Chim J.C.S., Wong A.S.Y. and Kwong Y.L., Epigenetic inactivation of INK4/CDK/RB cell cycle pathway in acute leukemias, Annals of Hematology . 2003, 82(12): 738-42.

Researcher : Wong BCY

Project Title:	The role of free radicals in peptic ulcer and gastric cancer
Investigator(s):	Dr. Wong B.C.Y., Prof. Fung P.C.W., Prof. Lam S.K.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	07/1998

Abstract:

To study the role of nitric oxide in the pathogenesis of gastric diseases; to study the clinical and in vivo detection of nitric oxide or other free radicals in human gastric sytsem; to screen for and monitor new potential pharmacological agents on modification of free radical production.

Project Title:	Effect of XAF1 gene on tumor growth in gastric and colon cancer
Investigator(s):	Dr. Wong B.C.Y., Dr. Tu S.P.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	01/2003

Abstract:

To study the effect of XAF1 on tumor growth.

Project Title:	Regulation of hTERT in relation to non-steroidal anti-inflammatory drugs in gastronintestinal carcinogenesis
Investigator(s):	Dr. Wong B.C.Y., Dr. Lin M.C.M.
Department:	Medicine
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	10/2003

Abstract:

Identify the cis-element responsible for NSAIDs-mediated inhibition of hTERT transcription; charaterize the transcription factor(s) and binding sites that is responsible for NSAIDs-mediated inhibition of hTERT transcription.

Project Title:	Regulation of hTERT in relation to non-steroidal anti-inflammatory drugs in gastronintestinal carcinogenesis
Investigator(s):	Dr. Wong B.C.Y., Dr. Lin M.C.M.
Department:	Medicine
Source(s) of Funding:	RGC Projects (Block Grant Funded)
Start Date:	10/2003

Abstract:

Project Title:	Role of Bcl-2 family proteins in non-steroidal anti-inflammatory drug-induced apoptosis of gastric cancer
Investigator(s):	Dr. Wong B.C.Y., Dr. Xia H.H.X.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	02/2004

Abstract:

To clarify the role of Bcl-2 family proteins in NSAID-induced apoptosis in vitro in this proposal using gastric cancer cell lines.

List of Research Outputs

Au W.Y., Wong R.W.M., Wong B.C.Y., Lie A.K.W., Liang R.H.S., Leung A.Y.H. and Kwong Y.L., Reduced incidence of acute graft versus host disease of the gut in Chinese carriers of Helicobacter pylori during allogeneic bone marrow transplantation, Annals of Hematology. 2004, 83: 34-37.

Chan A.O.O. and Wong B.C.Y., Screening for colorectal cancer, The Hong Kong Medical Diary. 2003, 8(1): 3-5.

Chan O.O., Yuen M.F., Lam C.M., Fong C.Y., Wong B.C.Y. and Lai C.L., Prevalence and Characteristics of Familial Hepatocellular Carcinoma Caused by Chronic Hepatitis B Infection in Hong Kong, Alimentary Pharmacology and Therapeutics. 2004, 19(4): 401-6.

Chan O.O., Wong W.M., Lam S.K. and Wong B.C.Y., Prevention of Gastric Cancer, Chinese Journal of Digestive Diseases. 2003, 4: 100-104.

Chan O.O., Peng J., Lam S.K., Hui W.M., Wong R.W.M., Yuen M.F., Kwong Y.L., Rashid A. and Wong B.C.Y., Reveral of E-Cadherin Promoter Hypermethylation Status after Helicobacter pylori Eradication, Gastroenterology. 2004, 126 (4 Suppl 2): 333.

Hui C.K., Lai K.C., Yuen M.F., Ng M.M.T., Chan C.K., Hu H.C., Wong R.W.M., Lai C.L. and Wong B.C.Y., Does the Addition of Endoscopic Sphincterotomy to Stent Insertion Improve Drainage of the Bile Duct in Acute Suppurative Cholangitis?, Gastrointestinal Endoscopy. 2003, 58(4): 500-4.

Hui C.K., Liu C.L., Lai K.C., Chan S.C., Hu H.C., Wong R.W.M., Cheung W.W., Ng M.M.T., Yuen M.F., Chan O.O., Lo C.M., Fan S.T. and Wong B.C.Y., Outcome of emergency ERCP for acute cholangitis in patients 90 years of age and older, Alimentary Pharmacology and Therapeutics. 2004, 19(11): 1153-1158.

Hui C.K., Lai K.C., Yuen M.F., Wong R.W.M., Chan O.O., Ng M.M.T., Chan C.K., Cheung W.W., Lam S.K., Lai C.L. and Wong B.C.Y., The Role of Cholecystectomy in Reducing Recurrent Gallstone Pancreatitis, Endoscopy. 2004, 36(3): 206-11.

Jiang X. and Wong B.C.Y., Cyclooxygenase-2 Inhibition and Gastric Cancer, Current Pharmaceutical Design. 2003, 9(27): 2281-8.

Lai K.C., Lam S.K., Chu K.M., Hui W.M., Kwok K.F., Wong B.C.Y., Hu H.C., Wong R.W.M., Chan O.O. and Chan C.K., Lansoprazole Reduces Ulcer Relapse after Eradication of Helicobacter pylori in Nonsteroidal Anti-Inflammatory Drug Users--a Randomized Trial, Alimentary Pharmacology and Therapeutics. 2003, 18(8): 829-36.

Lam S.K. and Wong B.C.Y., The Role of Cyclooxygenase in Gastrointestinal Diseases, Journal of Gastroenterology and Hepatology. 2003, 18(Suppl): A5.

Li G., Xia H.H.X., Chen M.H., Peng J., Gu Q., Cui J., Cho C.H., Lam S.K., Lin M.C., Berg D.E., Feng Z., Langenbach R., Kung H. and Wong B.C.Y., Cyclooxygenase-2 Gene Disruption Enhances Gastric Inflammation but Inhibits Gastric Epithelial Proliferation Induced by H. pylori Infection, Gastroenterology. 2004, 126 (4 Suppl 2): W907.

Ng F.H., Wong B.C.Y., Wong S.Y., Chen W.H. and Chang P.C.M., Clopidogrel plus Omeprazole Compared with Aspirin plus Omeprazole for Aspirin-Induced Symptomatic Peptic Ulcers/Erosions with Low to Moderate Bleeding/Re-Bleeding Risk -- a Single-Blind, Randomized Controlled Study, Alimentary Pharmacology and Therapeutics. 2004, 19(3): 359-65.

Ng F.H., Wong S.Y., Chang P.C.M., Chen W.H., Kng N., Lanas A.I. and Wong B.C.Y., High Incidence of Clopidogrel-Associated Gastrointestinal Bleeding in Patients with Previous Peptic Ulcer Disease, Alimentary Pharmacology and Therapeutics. 2003, 18(4): 443-9.

Tu S., Chan O.O., Lin M.C., Jiang X., Lam S.K., Kung H. and Wong B.C.Y., Livin, a Novel Member of Inhibitor of Apoptosis, Is Marker of Poor Prognosis in Gastric Cancer, Gastroenterology. 2004, 126 (4 Suppl 2): T1256.

Tu S., Jiang X., Lin M.C., Cui J., Yang Y., Lum C.T., Zou B., Zhu Y.B., Jiang S.H., Wong W.M., Chan O.O., Yuen M.F., Lam S.K., Kung H. and Wong B.C.Y., Suppression of Survivin Expression Inhibits in vivo Tumorigenicity and Angiogenesis in Gastric Cancer, Cancer Research. 2003, 63(22): 7724-7732.

Wang J., Gu Q., Xia H.H.X., Tu S., Peng J., Yang Y., Zou B., Lin M.C., Kung H., Lam S.K. and Wong B.C.Y., JNK1 Up-Regulates the Expression of XIAP-Associated Factor 1 (XAF1) by a P53-Dependent Pathway in Gastrointestinal Cancer, Gastroenterology. 2004, 126 (4 Suppl 2): M946.

Wang W., Huang J., Zheng G., Lam S.K., Karlberg J.P.E. and Wong B.C.Y., Non-Steroidal Anti-Inflammatory Drug Use and the Risk of Gastric Cancer: A Systematic Review and Meta-Analysis, Journal of the National Cancer Institute. 2003, 95(23): 1784-1791.

Wong B.C.Y., Wong R.W.M., Cheung K.L., Tong S.M., Rozen P., Young G.P., Chu K.W., Ho J.W.C., Law W.L., Tung H.M., Lai K.C., Hu H.C., Chan C.K. and Lam S.K., A Sensitive Guaiac Fecal Occult Blood Test is Less Useful than an Immunochemical Test for Colorectal Cancer Screening in a Chinese Population , Alimentary Pharmacology and Therapeutics. 2003, 18(9): 941-946.

Wong B.C.Y., Tu S., Kung H. and Lin M.C., A novel cocktail therapy for colon cancer: Combination of Adeno-associated virus (AAV) based survivin mutant gene therapy with chemotherapy, US Provisional patent filed June 2004. 2004.

Wong B.C.Y., Jiang X., Lin M.C., Tu S., Cui J., Jiang S.H., Wong R.W.M., Yuen M.F., Lam S.K. and Kung H., Cyclooxygenase-2 Inhibitor (SC-236) Suppresses Activator Protein-1 through c-Jun NH2-Terminal Kinase, Gastroenterology. 2004, 126: 136-147.

Wong B.C.Y., H. pylori eradication: does it prevent gastric cancer?, Journal of Gastroenterology and Hepatology. 2003, 18 (9 Suppl): A5.

Wong B.C.Y., Lam S.K., Wong R.W.M., Chen J.S., Zheng T., Feng R., Lai K.C., Hu H.C., Yuen S.T., Leung S.Y., Fong D.Y.T., Ho J.C.Y., Ching C.K. and Chen J.S., Helicobacter pylori Eradication to Prevent Gastric Cancer in a High-Risk Region of China: a Randomized Controlled Trial, The Journal of American Medical Association. 2004, 291(2): 187-194.

Wong B.C.Y., Lam S.K., Wong R.W.M., Chen J.S., Zheng T., Feng R., Lai K.C., Hu H.C., Yuen S.T., Leung S.Y., Fong D.Y.T., Ho J.W.C. and Ching C.K., Helicobacter pylori eradication to prevent gastric cancer in a high-risk region in China: A randomized controlled trial, JAMA. 2004, 291(2): 187-194.

Wong R.W.M., Hui W.M. and Wong B.C.Y., Asia-Pacific Consensus on Gastroesophageal Reflux Disease, Journal of Gastroenterology and Hepatology. 2004, 19(4): 353-6.

Wong R.W.M., Cheng C. and Wong B.C.Y., Constipation, Medical Progress. 2004, 31(4): 201-207.

Wong R.W.M., Lai K.C., Hui W.M., Lam K.F., Huang J., Hu H.C., Wong Y.H., Lam C.L.K., Xia H.H.X., Chan O.O., Lam S.K. and Wong B.C.Y., Double-blind, Randomized Controlled Study to Assess the Effects of Lansoprazole 30 mg and Lansoprazole 15 mg on 24-h Oesophageal and Intragastric pH in Chinese Subjects with Gastro-Oesophageal Reflux Disease, Alimentary Pharmacology and Therapeutics. 2004, 19(4): 455-62.

Wong R.W.M., Hui W.M. and Wong B.C.Y., Gastro-Oesophageal Reflux Disease – An Update, Medical Progress. 2003, 30(10): 41-48.

Wong R.W.M., Cheng C., Hui W.M. and Wong B.C.Y., Irritable Bowel Syndrome, Medical Progress. 2003, 30(8): 50-55.

Wong R.W.M. and Wong B.C.Y., NCCP: An Asian View, Gastroenterology Clinic of North America. 2004, 33: 125-133.

Wong R.W.M., Hui W.M. and Wong B.C.Y., Non-Erosive Reflux Disease, Medical Progress. 2003, 30(11): 41-47.

Wong R.W.M., Lai K.C., Hui W.M., Hu H.C., Huang J., Wong Y.H., Xia H.H.X., Chan O.O., Lam S.K. and Wong B.C.Y., Pathophysiology of Gastro-oesophageal Reflux Diseases in Chinese – Role of Transient Lower Oesophageal Sphincter Relaxation and Oesophageal Motor Dysfunction, Gastroenterology. 2004, 126 (4 Suppl 2): T1724.

Wong R.W.M., Lam K.F., Cheng C., Hui W.M., Xia H.H.X., Lai K.C., Hu H.C., Huang J., Lam C.L.K., Chan C.K., Chan O.O., Lam S.K. and Wong B.C.Y., Population Based Study of Noncardiac Chest Pain in Southern Chinese: Prevalence, Psychosocial Factors and Health Care Utilization, World Journal of Gastroenterology. 2004, 10(5): 707-712.

Wong W.M., Gu Q., Wang W., Fung F.M.Y., Berg D.E., Lai K.C., Xia H.H.X., Hu H.C., Chan C.K., Chan O.O., Yuen M.F., Hui C.K., Lam S.K. and Wong B.C.Y., Effects of Primary Metronidazole and Clarithromycin Resistance to Helicobacter pylori on Omeprazole, Metronidazole, and Clarithromycin Triple-Therapy Regimen in a Region with High Rates of Metronidazole Resistance, Clinical Infectious Diseases. 2003, 37(7): 882-9.

Wong W.M., Lam S.K., Tong S.M., Cheung K.L., Tang V.S.Y., Xia H.H.X., Lai K.C., Hu H.C., Chan C.K., Yuen M.F., Chan O.O. and Wong B.C.Y., Evaluation of a Rapid Stool Antigen Test for the Diagnosis of Helicobacter pylori Infection in Chinese Patients, Chinese Journal of Digestive Diseases. 2003, 4: 132-135.

Wong W.M., Lai K.C., Lam K.F., Hui W.M., Hu H.C., Lam C.L.K., Xia H.H.X., Huang J., Chan C.K., Lam S.K. and Wong B.C.Y., Prevalence, Clinical Spectrum and Health Care Utilization of Gastro-Oesophageal Reflux Disease in a Chinese Population: a Population-Based Study, Alimentary Pharmacology and Therapeutics. 2003, 18(6): 595-604.

Wong W.M., Ho J.C.M., Hung I.F., Ng W., Lam Y.M., Tam W.O., Wong B.C.Y., Wong P.C., Lai C.L., Lam W.K., Lam S.K., Tsang K.W.T., Ooi C.G.C., Ho P.L., Mok T. and Chan J., Temporal Patterns of Hepatic Dysfunction and Disease Severity in Patients with SARS, Journal of the American Medical Association Southeast Asia (JAMA). 2003, 290(20): 2663-2665.

Xia H.H.X. and Wong B.C.Y., Nitric Oxide in Helicobacter pylori-Induced Apoptosis and its Significance in Gastric Carcinogenesis, Journal of Gastroenterology and Hepatology. 2003, 18(11): 1227-30.

Xia H.H.X., Yang Y. and Wong B.C.Y., Relationship between Helicobacter pylori infection and gastro-esophageal reflux disease., Chinese Journal of Digestive Diseases . 2004, 5: 1-6.

Yang Y., Lin M.C., Ching Y.P., Lam S.K., Xia H.H.X., Tu S., Zou B., Wang J., Li G., He H., Gu Q., Peng J., Kung H. and Wong B.C.Y., FHL2 As a Co-Factor of XAF1 in the Induction of Apoptosis, Gastroenterology. 2004, 126 (4 Suppl 2): S938.

Yuen M.F., Wong D.K.H., Sablon E., Yuan H., Sum S.M., Hui C.K., Chan O.O., Wong B.C.Y. and Lai C.L., Hepatitis B Virus Genotypes B and C Do Not Affect The Antiviral Response To Lamivudine, Antiviral Therapy. 2003, 8: 531-534.

Yuen M.F., Wong D.K.H., Sablon E., Yuan H., Sum S.M., Hui C.K., Wong B.C.Y. and Lai C.L., Hepatitis B Virus Genotypes B and C Do Not Affect the Anti-viral Response to Lamivudine, Hepatology. 2003, 38, No. 4, Suppl. 1: 723A.

Yuen M.F., Sablon E., Wong K.H.D., Yuan H., Wong B.C.Y., Chan O.O. and Lai C.L., Role of Hepatitis B Virus Genotypes in Chronic Hepatitis B Exacerbation, Clinical Infectious Diseases. 2003, 37: 593-7.

Zou B., Lin M.C., Lam S.K., Tu S., Yang Y., Wang J., He H., Peng J., Kung H. and Wong B.C.Y., Hypermethylation Status Around Exon 1 of XIAP-Associated Factor 1 in Human Gastric and Colon Cancer Cell Lines, Gastroenterology. 2004, 126 (4 Suppl 2): T981.

Researcher : Wong DKH

List of Research Outputs

Yuan H., Yuen M.F., Wong D.K.H., Sum S.M., Doutreloigne J., Sablon E. and Lai C.L., Determinants for the Occurrence of Acute Exacerbation after HBeAg Seroclearance in Chinese Patients, Hepatology. 2003, 38, No. 4, Suppl. 1: 623A.

Yuen M.F., Kato T., Mizokami M., Chan O.O., Yuen J.C.H., Yuan H., Wong D.K.H., Sum S.M., Ng I.O.L., Fan S.T. and Lai C.L., Clinical outcome and virologic profiles of severe hepatitis B exacerbation due to YMDD mutations, Journal of Hepatology. 2003, 39(5): 850-855.

Yuen M.F., Wong D.K.H., Sablon E., Tse E.W.C., Ng I.O.L., Yuan H., Siu C.W., Sander T.J., Bourne E.J., Hall J.G., Condreay L.D. and Lai C.L., HBsAg seroclearance in chronic hepatitis B in the Chinese: Virological, histological, and clinical aspects, Hepatology. 2004, 39(6): 1694-1701.

Yuen M.F., Wong D.K.H., Sablon E., Yuan H., Sum S.M., Hui C.K., Chan O.O., Wong B.C.Y. and Lai C.L., Hepatitis B Virus Genotypes B and C Do Not Affect The Antiviral Response To Lamivudine, Antiviral Therapy. 2003, 8: 531-534.

Yuen M.F., Wong D.K.H., Sablon E., Yuan H., Sum S.M., Hui C.K., Wong B.C.Y. and Lai C.L., Hepatitis B Virus Genotypes B and C Do Not Affect the Anti-viral Response to Lamivudine, Hepatology. 2003, 38, No. 4, Suppl. 1: 723A.

Researcher : Wong KHD

List of Research Outputs

Yuen M.F., Sablon E., Wong K.H.D., Yuan H., Wong B.C.Y., Chan O.O. and Lai C.L., Role of Hepatitis B Virus Genotypes in Chronic Hepatitis B Exacerbation, Clinical Infectious Diseases. 2003, 37: 593-7.

Researcher : Wong LC

List of Research Outputs

Dan Q., Yin S., Wong L.C., Chung S.K., Chung S.S.M. and Lam K.S.L., Interaction between the polyol pathway and non-enzymatic glycation on aortic smooth muscle cell migration and monocyte adhesion in a transgenic mouse model, 15th Annual Scientific Meeting of Hong Kong Society of Endocrinology, Metabolism and Reproduction, October 2003, Hong Kon. 2003.

Dan Q., Yin S., Wong L.C., Chung S.K., Chung S.S.M. and Lam K.S.L., Interaction between the polyol pathway and non-enzymatic glycation on aortic smooth muscle cell migration and monocyte adhesion in a transgenic mouse model, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Dan Q., Yin S., Wong L.C., Chung S.K., Chung S.S.M. and Lam K.S.L., Interaction between the polyol pathway and non-enzymatic glycation on aortic smooth muscle cell mirgration and moncyte adhesion in a transgenic mouse model, XIIIth International Symposium on Atherosclerosis, Sep 28-Oct 2, 2003, Kyoto, Japan. European Atherosclerosis Society, 2003, 1P-0137.

Dan Q., Wong L.C., Cheng K.Y., Chung S.S.M., Chung S.K. and Lam K.S.L., The polyol pathway and diabetic atherosclerosis, The 3rd International Huaxia Congress of Endocrinology, May 25 – 28, 2004, Shanghai, China. 2004.

Lam K.S.L., Dan Q., Yin S., Wong L.C., Chung S.K. and Chung S.S.M., Interaction between non-enzymatic glycation and the polyol pathway on mesangial cell gene expression in an aldose reductase transgenic mouse model, The 18th International Diabetes Federation Congress, August 24-29, 2003, Paris, France. 2003.

Lee K.K., Xu A., Tan K.C.B., Wong L.C., Tiu S.C., Tam S.C.F. and Lam K.S.L., Serum adiponectin is reduced in acromegaly and normalized after correction of growth hormone excess, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Tso A.W.K., Wat N.M.S., Janus E.D., Wong L.C., Tan K.C.B. and Lam K.S.L., Effect of endothelial nitric oxide synthase polymorphism (GLU298Asp) on the progression of glycaemia in Chinese subjects with impaired glucose tolerance, 15th Annual Scientific Meeting of Hong Kong Society of Endocrinology, Metabolism and Reproduction, October 2003, Hong Kong. 2003.

Tso A.W.K., Wat N.M.S., Janus E.D., Wong L.C., Tan K.C.B. and Lam K.S.L., Effect of endothelial nitric oxide synthase polymorphism (Glu298Asp) on the progression of glycaemia in Chinese subjects with impaired glucose tolerance, 18th International Diabetes Federation Congress, Paris, August 2003.

Xu A., Yin S., Wong L.C., Chan K.W. and Lam K.S.L., Adiponectin ameliorates dyslipidemia induced by the human immunodeficiency virus protease inhibitor ritonavir in mice, Endocrinology . 2004, 145: 487-94.

Xu A., Wong L.C. and Lam K.S.L., Growth hormone enhances adiponectin gene expression via P38 MAP kinase pathway in 3T3-L1 adipocytes, ENDO 2004, New Orleans, USA, 16-19 June 2004.. 2004.

Xu A., Yin S., Wong L.C., Chan K.W. and Lam K.S.L., The fat-derived hormone adiponectin ameliorates dyslipidemia induced by HIV protease inhibitors, 13th International Symposium on Atherosclerosis, September 28 – October 2, 2003, Kyoto, Japan. 2003.

Xu A., Yin S., Wong L.C., Chan K.W. and Lam K.S.L., The fat-derived hormone adiponectin ameliorates dyslipidemia induced by HIV protease inhibitors, 15th Annual Scientific Meeting of Hong Kong Society of Endocrinology, Metabolism and Reproduction, October 2003, Hong Kong. 2003.

Researcher : Wong LYF

List of Research Outputs

Cheung B.M.Y., Wong L.Y.F., Li Y.Y., Hwang I.S.S. and Tang F., Adrenomedullin expression and cytokine response in experimentally induced endotoxaemia, Neuropeptides. 2004, 38: 126.

Cheung B.M.Y., Wong L.Y.F., Li Y.Y. and Tang F., The cytokine response of rat macrophages to lipopolysaccharide is modulated by adrenomedullin, Hong Kong Medical Journal. 2003, 9(1) Suppl: 26.

Cheung B.M.Y., Leung Y.H., Wong L.Y.F., Man Y.B., Lau C.P. and Kumana C.R., Urotensin II in hypertension, Hong Kong Medical Journal. 2003, 9(1) Suppl: 24.

Wong L.Y.F., Cheung B.M.Y., Li Y.Y. and Tang F., Adrenomedullin expression and its effects on cytokine response of rat macrophages to lipopolysaccharide, Neuropeptides. 2004, 38: 117.

Wong L.Y.F., Cheung B.M.Y., Li Y.Y. and Tang F., Adrenomedullin suppresses MIF production and cytokine response of rat macrophages to lipopolysaccharide, Journal of Hong Kong College of Cardiology. 2003, 11(Suppl 1): A17.

Wong L.Y.F., Cheung B.M.Y., Li Y.Y., Tang F. and Lan H.Y., Adrenomedullin suppresses migration inhibitory factor production and cytokine response of rat macrophages to lipopolysaccharide, Hong Kong Medical Journal. 2003, 9(1) Suppl: 29.

Xu A., Yiu S., Wong L.Y.F., Chan W.K. and Lam K.S.L., The fat-derived hormone adiponectin ameliorates dyslipidemia induced by HIV protease inhibitors, XIII International Symposium on Atherosclerosis, September 28-October 2, 2003, Kyoto, Japan . The European Atherosclerosis Society, 2003, Sep 2003: 242 (3P-0821*).

Researcher : Wong MS

List of Research Outputs

Chan K., Wong M.S., Chan T.K. and Chan V.N.Y., A Thalassaemia Array For Southeast Asia, British Journal of Haematology. 2004, 124: 232-239.

Researcher : Wong PC

List of Research Outputs

Ho J.C.M., Wong R.W.M., Ooi C.G.C., Mok T.Y., Hung I.F., Ng W., Lam Y.M., Tam W.O., Wong P.C., Ho P.L., Lai C.L., Lam W.K., Lam S.K. and Tsang K.W.T., Correlation of Liver Dysfunction And Disease Activity In Patients With Severe Acute Respiratory Syndrome, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-08.

Ho J.C.M., Ooi C.G.C., Mok T.Y., Chan J.W., Hung I., Lam B., Wong P.C., Li P.C., Ho P.L., Lam W.K., Ng C.K., Ip M.S.M., Lai K.N., Chan M.M.W. and Tsang K.W.T., High-dose pulse versus nonpulse corticosteroid regimens in severe acute respiratory syndrome, American Journal of Respiratory and Critical Care Medicine. 2003, 168: 1449-1456.

Jones B.M., Ma E.S.K., Peiris J.S.M., Wong P.C., Ho J.C.M., Lam B., Lai K.N. and Tsang K.W.T., Prolonged disturbances of in vitro cytokine production in patients with severe acute respiratory syndrome (SARS) treated with ribavirin and steroids, Clinical & Experimental Immunology. 2004, 135: 467-473.

Lam M.F., Ooi C.G.C., Lam B., Ho J.C.M., Seto W.H., Ho P.L., Wong P.C., Liang R.H.S., Lam W.K. and Tsang K.W.T., An indolent case of severe acute respiratory syndrome, American Journal of Respiratory and Critical Care Medicine. 2004, 169(1): 125-128.

Ooi C.G.C., Khong P.L., Lam B., Ho J.C.M., Yiu W.C., Wong R.W.M., Wang T., Ho P.L., Wong P.C., Chan R.H., Lam W.K., Lai K.N. and Tsang K.W.T., Relationship between radiological and clinical parameters in SARS, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia, 2003. Abstract Book: OP2-01, p.73.

Ooi C.G.C., Khong P.L., Ho J.C.M., Lam B., Wong R.W.M., Yiu M.W.C., Wong P.C., Wong C.F., Lai K.N. and Tsang K.W.T., Severe acute respiratory syndrome: radiographic evaluation and clinical outcome measures, Radiology. 2003, 229: 500-506.

Wong W.M., Ho J.C.M., Hung I.F., Ng W., Lam Y.M., Tam W.O., Wong B.C.Y., Wong P.C., Lai C.L., Lam W.K., Lam S.K., Tsang K.W.T., Ooi C.G.C., Ho P.L., Mok T. and Chan J., Temporal Patterns of Hepatic Dysfunction and Disease Severity in Patients with SARS, Journal of the American Medical Association Southeast Asia (JAMA). 2003, 290(20): 2663-2665.

Researcher : Wong RWM

List of Research Outputs

Au W.Y., Wong R.W.M., Khoo U.S. and Liang R.H.S., Concurrent aggressive gastrointestinal stromal tumour (GIST) and Burkitt’s lymphoma., Journal of Clinical Oncology. 2003, 21: 1417 – 1418.

Au W.Y., Wong R.W.M., Wong B.C.Y., Lie A.K.W., Liang R.H.S., Leung A.Y.H. and Kwong Y.L., Reduced incidence of acute graft versus host disease of the gut in Chinese carriers of Helicobacter pylori during allogeneic bone marrow transplantation, Annals of Hematology. 2004, 83: 34-37.

Chan O.O., Peng J., Lam S.K., Hui W.M., Wong R.W.M., Yuen M.F., Kwong Y.L., Rashid A. and Wong B.C.Y., Reveral of E-Cadherin Promoter Hypermethylation Status after Helicobacter pylori Eradication, Gastroenterology. 2004, 126 (4 Suppl 2): 333.

Ho J.C.M., Wong R.W.M., Ooi C.G.C., Mok T.Y., Hung I.F., Ng W., Lam Y.M., Tam W.O., Wong P.C., Ho P.L., Lai C.L., Lam W.K., Lam S.K. and Tsang K.W.T., Correlation of Liver Dysfunction And Disease Activity In Patients With Severe Acute Respiratory Syndrome, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-08.

Hui C.K., Lai K.C., Yuen M.F., Ng M.M.T., Chan C.K., Hu H.C., Wong R.W.M., Lai C.L. and Wong B.C.Y., Does the Addition of Endoscopic Sphincterotomy to Stent Insertion Improve Drainage of the Bile Duct in Acute Suppurative Cholangitis?, Gastrointestinal Endoscopy. 2003, 58(4): 500-4.

Hui C.K., Liu C.L., Lai K.C., Chan S.C., Hu H.C., Wong R.W.M., Cheung W.W., Ng M.M.T., Yuen M.F., Chan O.O., Lo C.M., Fan S.T. and Wong B.C.Y., Outcome of emergency ERCP for acute cholangitis in patients 90 years of age and older, Alimentary Pharmacology and Therapeutics. 2004, 19(11): 1153-1158.

Hui C.K., Lai K.C., Yuen M.F., Wong R.W.M., Chan O.O., Ng M.M.T., Chan C.K., Cheung W.W., Lam S.K., Lai C.L. and Wong B.C.Y., The Role of Cholecystectomy in Reducing Recurrent Gallstone Pancreatitis, Endoscopy. 2004, 36(3): 206-11.

Lai K.C., Lam S.K., Chu K.M., Hui W.M., Kwok K.F., Wong B.C.Y., Hu H.C., Wong R.W.M., Chan O.O. and Chan C.K., Lansoprazole Reduces Ulcer Relapse after Eradication of Helicobacter pylori in Nonsteroidal Anti-Inflammatory Drug Users--a Randomized Trial, Alimentary Pharmacology and Therapeutics. 2003, 18(8): 829-36.

Ooi C.G.C., Khong P.L., Lam B., Ho J.C.M., Yiu W.C., Wong R.W.M., Wang T., Ho P.L., Wong P.C., Chan R.H., Lam W.K., Lai K.N. and Tsang K.W.T., Relationship between radiological and clinical parameters in SARS, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia, 2003. Abstract Book: OP2-01, p.73.

Ooi C.G.C., Khong P.L., Lam B., Ho J.C.M., Yiu W.C., Wong R.W.M., Wang T., Ho P.L., Chan R.H., Lam W.K., Lai K.N. and Tsang K.W.T., Severe acute respiratory syndrome : Relationship between radiological and clinical parameters, Radiology. 2003, 229: 492-499.

Ooi C.G.C., Khong P.L., Ho J.C.M., Lam B., Wong R.W.M., Yiu M.W.C., Wong P.C., Wong C.F., Lai K.N. and Tsang K.W.T., Severe acute respiratory syndrome: radiographic evaluation and clinical outcome measures, Radiology. 2003, 229: 500-506.

Wong B.C.Y., Wong R.W.M., Cheung K.L., Tong S.M., Rozen P., Young G.P., Chu K.W., Ho J.W.C., Law W.L., Tung H.M., Lai K.C., Hu H.C., Chan C.K. and Lam S.K., A Sensitive Guaiac Fecal Occult Blood Test is Less Useful than an Immunochemical Test for Colorectal Cancer Screening in a Chinese Population , Alimentary Pharmacology and Therapeutics. 2003, 18(9): 941-946.

Wong B.C.Y., Jiang X., Lin M.C., Tu S., Cui J., Jiang S.H., Wong R.W.M., Yuen M.F., Lam S.K. and Kung H., Cyclooxygenase-2 Inhibitor (SC-236) Suppresses Activator Protein-1 through c-Jun NH2-Terminal Kinase, Gastroenterology. 2004, 126: 136-147.

Wong B.C.Y., Lam S.K., Wong R.W.M., Chen J.S., Zheng T., Feng R., Lai K.C., Hu H.C., Yuen S.T., Leung S.Y., Fong D.Y.T., Ho J.C.Y., Ching C.K. and Chen J.S., Helicobacter pylori Eradication to Prevent Gastric Cancer in a High-Risk Region of China: a Randomized Controlled Trial, The Journal of American Medical Association. 2004, 291(2): 187-194.

Wong B.C.Y., Lam S.K., Wong R.W.M., Chen J.S., Zheng T., Feng R., Lai K.C., Hu H.C., Yuen S.T., Leung S.Y., Fong D.Y.T., Ho J.W.C. and Ching C.K., Helicobacter pylori eradication to prevent gastric cancer in a high-risk region in China: A randomized controlled trial, JAMA. 2004, 291(2): 187-194.

Wong R.W.M., Hui W.M. and Wong B.C.Y., Asia-Pacific Consensus on Gastroesophageal Reflux Disease, Journal of Gastroenterology and Hepatology. 2004, 19(4): 353-6.

Wong R.W.M., Cheng C. and Wong B.C.Y., Constipation, Medical Progress. 2004, 31(4): 201-207.

Wong R.W.M., Lai K.C., Hui W.M., Lam K.F., Huang J., Hu H.C., Wong Y.H., Lam C.L.K., Xia H.H.X., Chan O.O., Lam S.K. and Wong B.C.Y., Double-blind, Randomized Controlled Study to Assess the Effects of Lansoprazole 30 mg and Lansoprazole 15 mg on 24-h Oesophageal and Intragastric pH in Chinese Subjects with Gastro-Oesophageal Reflux Disease, Alimentary Pharmacology and Therapeutics. 2004, 19(4): 455-62.

Wong R.W.M., Hui W.M. and Wong B.C.Y., Gastro-Oesophageal Reflux Disease – An Update, Medical Progress. 2003, 30(10): 41-48.

Wong R.W.M., Cheng C., Hui W.M. and Wong B.C.Y., Irritable Bowel Syndrome, Medical Progress. 2003, 30(8): 50-55.

Wong R.W.M., Management of Gastroesophageal Reflux Disease, The Hong Kong Society of Physicians of Hong Kong. 2003.

Wong R.W.M. and Wong B.C.Y., NCCP: An Asian View, Gastroenterology Clinic of North America. 2004, 33: 125-133.

Wong R.W.M., Hui W.M. and Wong B.C.Y., Non-Erosive Reflux Disease, Medical Progress. 2003, 30(11): 41-47.

Wong R.W.M., Lai K.C., Hui W.M., Hu H.C., Huang J., Wong Y.H., Xia H.H.X., Chan O.O., Lam S.K. and Wong B.C.Y., Pathophysiology of Gastro-oesophageal Reflux Diseases in Chinese – Role of Transient Lower Oesophageal Sphincter Relaxation and Oesophageal Motor Dysfunction, Gastroenterology. 2004, 126 (4 Suppl 2): T1724.

Wong R.W.M., Lam K.F., Cheng C., Hui W.M., Xia H.H.X., Lai K.C., Hu H.C., Huang J., Lam C.L.K., Chan C.K., Chan O.O., Lam S.K. and Wong B.C.Y., Population Based Study of Noncardiac Chest Pain in Southern Chinese: Prevalence, Psychosocial Factors and Health Care Utilization, World Journal of Gastroenterology. 2004, 10(5): 707-712.

Wong R.W.M., Prevalence and Simplified Diagnosis of GERD in Hong Kong Chinese, Annual Scientific Meeting, Hong Kong Society of Gastrointestinal Motility. 2003.

Wong R.W.M., Prevalence, Clinical Spectrum and Health Care Utilisation of Gastro-Oesophageal Reflux Disease in Chinese Population: a Population-Based Study , 8th Research Postgraduate Symposium 2003, University of Hong Kong. 2003.

Wong R.W.M. and Wong A.T.Y., Viral Gastroenteritis - Rotavirus and Norovirus Infection, Medical Progress. 2004, 31(5): 245-9.

Researcher : Wong RWS

List of Research Outputs

Mok C.C., Ying S.K.Y., Lau W.C.S., Yim C.W., Ng W.L., Wong R.W.S. and Au T.C., An open-label study of combined prednisone and azathioprine in the treatment of pure membranous lupus nephropathy, 7th International Congress on SLE and Related Conditions, New York. 2004.

Mok C.C., Ying S.K.Y., Tang S.S.K., Leung C.Y., Lee K.W., Ng W.L., Wong R.W.S. and Lau W.C.S., Predictors and outcome of renal flares after successful cyclophosphamide treatment for diffuse proliferative lupus glomerulonephritis, The European League Against Rheumatism (EULAR) Annual Congress for Rheumatology, Berlin, Germany. 2004.

Mok C.C., Wong R.W.S. and Lai K.N., Treatment of severe proliferative lupus nephritis: the current state, Annals of the Rheumatic Diseases. 2003, 62: 799-804.

Mok T.M.Y., Chan E.Y.T., Leung K., Lo Y., Wong R.W.S. and Lau W.C.S., Antiphospholipid antibody profiles in Chinese patients with systemic lupus erythematosus, The Hong Kong Practitioner. 2004, 2: RI-04.

Mok T.M.Y., Lao T.T.H., Collins R.J., Leung T.Y., Leung P.Y., Chan D.T.M., Wong R.W.S. and Lau W.C.S., Cervical dysplasia in patients with systemic lupus erythematosus, 7th International Congress on SLE and Related Condidtions, New York. 2004.

Mok T.M.Y., Lao T.T.H., Collins R.J., Leung T.Y., Leung P.Y., Lo Y., Chan D.T.M., Wong R.W.S. and Lau W.C.S., Cervical dysplasia in patients with systemic lupus erythematosus, The Hong Kong Practitioner. 2004, 2: RI-05.

Mok T.M.Y., Leung P.Y., Lao T.T.H., Lo Y., Chan D.T.M., Wong R.W.S. and Lau W.C.S., Clinical predictors of fetal and maternal outcome in Chinese patients with systemic lupus erythematosus, 7th International Congress on SLE and Related Conditions, New York. 2004.

Mok T.M.Y., Leung P.Y., Lao T.T.H., Chan D.T.M., Wong R.W.S. and Lau W.C.S., Clinical predictors of fetal and maternal outcome in Chinese patients with systemic lupus erythematosus, The Hong Kong Practitioner. 2004, 2: RI-053.

Mok T.M.Y., Lo Y., Chan D.T.M., Wong R.W.S. and Lau W.C.S., Efficacy of chemotherapy for tuberculosis infection in patients with systemic lupus erythematosus in an endemic area, The Hong Kong Practitioner. 2003, 9(Suppl 1): 65.

Researcher : Wong SY

List of Research Outputs

Ng F.H., Wong B.C.Y., Wong S.Y., Chen W.H. and Chang P.C.M., Clopidogrel plus Omeprazole Compared with Aspirin plus Omeprazole for Aspirin-Induced Symptomatic Peptic Ulcers/Erosions with Low to Moderate Bleeding/Re-Bleeding Risk -- a Single-Blind, Randomized Controlled Study, Alimentary Pharmacology and Therapeutics. 2004, 19(3): 359-65.

Ng F.H., Wong S.Y., Chang P.C.M., Chen W.H., Kng N., Lanas A.I. and Wong B.C.Y., High Incidence of Clopidogrel-Associated Gastrointestinal Bleeding in Patients with Previous Peptic Ulcer Disease, Alimentary Pharmacology and Therapeutics. 2003, 18(4): 443-9.

Researcher : Wong WM

List of Research Outputs

Chan O.O., Wong W.M., Lam S.K. and Wong B.C.Y., Prevention of Gastric Cancer, Chinese Journal of Digestive Diseases. 2003, 4: 100-104.

Hui C.K., Yuen M.F., Wong W.M., Lam S.K. and Lai C.L., Mirtazapine Induced Hepatotoxicity, Journal of Clinical Gastroenterology. 2003, 35(3): 270-271.

Preston S.L., Wong W.M., Chan O.O., Poulsom R., Jeffrey R., Goodlad R.A., Mandir N., Elia G., Novelli M., Bodmer W.F., Tomlinson I.P. and Wright N., Bottom-up Histogenesis of Colorectal Adenomas: Origin in the Monocryptal Adenoma and Initial Expansion by Crypt Fission, Cancer Research. 2003, 63: 3819-25.

Tu S., Jiang X., Lin M.C., Cui J., Yang Y., Lum C.T., Zou B., Zhu Y.B., Jiang S.H., Wong W.M., Chan O.O., Yuen M.F., Lam S.K., Kung H. and Wong B.C.Y., Suppression of Survivin Expression Inhibits in vivo Tumorigenicity and Angiogenesis in Gastric Cancer, Cancer Research. 2003, 63(22): 7724-7732.

Wong W.M., Gu Q., Wang W., Fung F.M.Y., Berg D.E., Lai K.C., Xia H.H.X., Hu H.C., Chan C.K., Chan O.O., Yuen M.F., Hui C.K., Lam S.K. and Wong B.C.Y., Effects of Primary Metronidazole and Clarithromycin Resistance to Helicobacter pylori on Omeprazole, Metronidazole, and Clarithromycin Triple-Therapy Regimen in a Region with High Rates of Metronidazole Resistance, Clinical Infectious Diseases. 2003, 37(7): 882-9.

Wong W.M., Lam S.K., Tong S.M., Cheung K.L., Tang V.S.Y., Xia H.H.X., Lai K.C., Hu H.C., Chan C.K., Yuen M.F., Chan O.O. and Wong B.C.Y., Evaluation of a Rapid Stool Antigen Test for the Diagnosis of Helicobacter pylori Infection in Chinese Patients, Chinese Journal of Digestive Diseases. 2003, 4: 132-135.

Wong W.M., Lai K.C., Lam K.F., Hui W.M., Hu H.C., Lam C.L.K., Xia H.H.X., Huang J., Chan C.K., Lam S.K. and Wong B.C.Y., Prevalence, Clinical Spectrum and Health Care Utilization of Gastro-Oesophageal Reflux Disease in a Chinese Population: a Population-Based Study, Alimentary Pharmacology and Therapeutics. 2003, 18(6): 595-604.

Wong W.M., Ho J.C.M., Hung I.F., Ng W., Lam Y.M., Tam W.O., Wong B.C.Y., Wong P.C., Lai C.L., Lam W.K., Lam S.K., Tsang K.W.T., Ooi C.G.C., Ho P.L., Mok T. and Chan J., Temporal Patterns of Hepatic Dysfunction and Disease Severity in Patients with SARS, Journal of the American Medical Association Southeast Asia (JAMA). 2003, 290(20): 2663-2665.

Researcher : Wong Y

List of Research Outputs

Tan K.C.B., Chow W.S., Wong Y., Shiu S.W.M. and Tam S.C.F., Effect of losartan on plasma C-reative protein in type 2 diabetic patients with microalbuminuria., In: Tan KCB, Chow WS, Wong Y, Shiu SWM, Tam SCF., Diabetes Care. 2003, 25: 1254.

Researcher : Wong YH

List of Research Outputs

Wong R.W.M., Lai K.C., Hui W.M., Lam K.F., Huang J., Hu H.C., Wong Y.H., Lam C.L.K., Xia H.H.X., Chan O.O., Lam S.K. and Wong B.C.Y., Double-blind, Randomized Controlled Study to Assess the Effects of Lansoprazole 30 mg and Lansoprazole 15 mg on 24-h Oesophageal and Intragastric pH in Chinese Subjects with Gastro-Oesophageal Reflux Disease, Alimentary Pharmacology and Therapeutics. 2004, 19(4): 455-62.

Wong R.W.M., Lai K.C., Hui W.M., Hu H.C., Huang J., Wong Y.H., Xia H.H.X., Chan O.O., Lam S.K. and Wong B.C.Y., Pathophysiology of Gastro-oesophageal Reflux Diseases in Chinese – Role of Transient Lower Oesophageal Sphincter Relaxation and Oesophageal Motor Dysfunction, Gastroenterology. 2004, 126 (4 Suppl 2): T1724.

Researcher : Wu AYY

Project Title:	Effects of triptolide in an animal model of contact dermatitis
Investigator(s):	Dr. Wu A.Y.Y.
Department:	Medicine
Source(s) of Funding:	Vice-Chancellor's Development Fund on Chinese Medicine
Start Date:	03/2000

Abstract:

To determine the effectiveness of tropical triptolide using an animal model of contact dermatitis

List of Research Outputs

Ho J.C.M., Wu A.Y.Y., Ooi C.G.C., Lam B., Ho P.L., Chan M.M.W., Ip M.S.M., Lam W.K. and Tsang K.W.T., Pentaglobin as rescue therapy in patients with severe acute respiratory syndrome, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-04.

Huang F., Ma L., Wu A.Y.Y., Tian L., Chan K.W., Chan A.K., Lam A.C., Lo C.K., Ko K.H., To K.W., Chik S., Kam S.K., Fong I., Li X.S., Ng M.H. and MacPherson G.G., Systemic autoimmune disease induced by dendritic cells that have captured dying cells, Proceedings of the Frontiers in Biomedical Research, Hong Kong. 12 December 2003.

Ma L., Chan A.K., Lam A.C., Chan K.W., Lo C.K., Ko K.H., To K.W., Wu A.Y.Y., Tian L., Ng M.H. and Huang F., The role of dendritic cells in the induction of systemic autoimmune disease, Proceedings of the 8th Research Postgraduate Symposium, Hong Kong, 13 December 2003.

Ren Y., Tang J., Mok T.M.Y., Chan A.W., Wu A.Y.Y. and Lau W.C.S., Increased apoptotic blood neutrophils and macrophages and decreased clearance of apoptotic neutrophils in systemic lupus erythematosus, Arthritis & Rheumatism. 2003, 48(10): 2888 - 2897.

Ren Y., Tang J.L., Mok T.M.Y., Chan W.K., Wu A.Y.Y. and Lau W.C.S., Increased apoptotic neutrophils and macrophages and impaired macrophage phagocytic clearance of apoptotic neutrophils in systemic lupus erythematosus, Arthritis & Rheumatism. 2003, 48: 2888-97.

Wu A.Y.Y., Ooi C.G.C., Lam B., Mok T.Y.M., Ho P.L., Chan M.M.W., Ip M.S.M., Lam W.K. and Tsang K.W.T., The use of pentaglobin in patients with deteriorating severe acute respiratory syndrome, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia . 2003, Abstract Book PP6-15: p.194.

Researcher : Wun YT

List of Research Outputs

Chung J., Wun Y.T. and Lam T.P., Vocational Training in Family Medicine: the Trainers' Perspectives, Hong Kong Practitioner. 2004, 26: 181-186.

Researcher : Xia HHX

Project Title:	Topographic association of helicobacter pylori infection with apoptosis and cell proliferation in the human stomach: roles of H. pylori-induced antralization in the pathogenesis of gastric cancer
Investigator(s):	Dr. Xia H.H.X., Prof. Lam S.K., Dr. Wong B.C.Y.
Department:	Medicine
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	10/2001

Abstract:

To elucidate the carcinogenesis of H.pylori infection at the molecular and cellular levels.

Project Title:	Homeobox genes in gastric carcinogenesis: an in vivo and in vitro study
Investigator(s):	Dr. Xia H.H.X., Dr. Wong B.C.Y.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	01/2003

Abstract:

To investigate the expression of gastric-related homeobox genes in human normal, precancerous and cancerous gastric tissues in vivo, and in non-malignant and malignant gastric cancer cell lines in vitro; to determine the effect of gastric-related homeobox genes on the secretion of gastric endocrine hormones.

Project Title:	Molecular and genetic mechanisms of helicobacter pylori-induced antralization in gastric carcinogenesis
Investigator(s):	Dr. Xia H.H.X., Dr. Wong B.C.Y.
Department:	Medicine
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	12/2003

Abstract:

To explore the molecular and genetic mechanisms of H. pylori-induced antralization in gastric carcinogenesis; to identify the initial physiological changes in the process of H. pylori-induced antralization (the presence of antral-type mucosa) and precancerous lesions at the gastric incisura; to determine whether these physiological changes can be used as biomarkers for H. pylori-induced antralization and precancerous lesions at the gastric incisura; to determine whether the process of H. pylori-induced antralization and precancerous lesions at the gastric incisura involves a mutation or other genetic changes in homeobox genes.

Project Title:	Molecular and genetic mechanisms of helicobacter pylori-induced antralization in gastric carcinogenesis
Investigator(s):	Dr. Xia H.H.X., Dr. Wong B.C.Y.
Department:	Medicine
Source(s) of Funding:	RGC Projects (Block Grant Funded)
Start Date:	12/2003

Abstract:

Project Title:	Role of cyclooxygenase in helicobacter pylori-induced gastric carcinogenesis
Investigator(s):	Dr. Xia H.H.X., Dr. Wong B.C.Y.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	02/2004

Abstract:

To reveal the precise mechanism of COX and interrelationship between COX and H. pylori infection in the pathogenesis of gastric cancer; to provide insights into whether specific targets can be dealth with by new drugs, or a combination of drugs on different cellular targets to potentiate the chemoprevention effects; to develop effective strategies in the prevention of gastric cancer, for which no active agent or drug is available at present.

List of Research Outputs

Li G., Xia H.H.X., Chen M.H., Peng J., Gu Q., Cui J., Cho C.H., Lam S.K., Lin M.C., Berg D.E., Feng Z., Langenbach R., Kung H. and Wong B.C.Y., Cyclooxygenase-2 Gene Disruption Enhances Gastric Inflammation but Inhibits Gastric Epithelial Proliferation Induced by H. pylori Infection, Gastroenterology. 2004, 126 (4 Suppl 2): W907.

Wang J., Gu Q., Xia H.H.X., Tu S., Peng J., Yang Y., Zou B., Lin M.C., Kung H., Lam S.K. and Wong B.C.Y., JNK1 Up-Regulates the Expression of XIAP-Associated Factor 1 (XAF1) by a P53-Dependent Pathway in Gastrointestinal Cancer, Gastroenterology. 2004, 126 (4 Suppl 2): M946.

Wong R.W.M., Lai K.C., Hui W.M., Lam K.F., Huang J., Hu H.C., Wong Y.H., Lam C.L.K., Xia H.H.X., Chan O.O., Lam S.K. and Wong B.C.Y., Double-blind, Randomized Controlled Study to Assess the Effects of Lansoprazole 30 mg and Lansoprazole 15 mg on 24-h Oesophageal and Intragastric pH in Chinese Subjects with Gastro-Oesophageal Reflux Disease, Alimentary Pharmacology and Therapeutics. 2004, 19(4): 455-62.

Wong R.W.M., Lai K.C., Hui W.M., Hu H.C., Huang J., Wong Y.H., Xia H.H.X., Chan O.O., Lam S.K. and Wong B.C.Y., Pathophysiology of Gastro-oesophageal Reflux Diseases in Chinese – Role of Transient Lower Oesophageal Sphincter Relaxation and Oesophageal Motor Dysfunction, Gastroenterology. 2004, 126 (4 Suppl 2): T1724.

Wong R.W.M., Lam K.F., Cheng C., Hui W.M., Xia H.H.X., Lai K.C., Hu H.C., Huang J., Lam C.L.K., Chan C.K., Chan O.O., Lam S.K. and Wong B.C.Y., Population Based Study of Noncardiac Chest Pain in Southern Chinese: Prevalence, Psychosocial Factors and Health Care Utilization, World Journal of Gastroenterology. 2004, 10(5): 707-712.

Wong W.M., Gu Q., Wang W., Fung F.M.Y., Berg D.E., Lai K.C., Xia H.H.X., Hu H.C., Chan C.K., Chan O.O., Yuen M.F., Hui C.K., Lam S.K. and Wong B.C.Y., Effects of Primary Metronidazole and Clarithromycin Resistance to Helicobacter pylori on Omeprazole, Metronidazole, and Clarithromycin Triple-Therapy Regimen in a Region with High Rates of Metronidazole Resistance, Clinical Infectious Diseases. 2003, 37(7): 882-9.

Wong W.M., Lam S.K., Tong S.M., Cheung K.L., Tang V.S.Y., Xia H.H.X., Lai K.C., Hu H.C., Chan C.K., Yuen M.F., Chan O.O. and Wong B.C.Y., Evaluation of a Rapid Stool Antigen Test for the Diagnosis of Helicobacter pylori Infection in Chinese Patients, Chinese Journal of Digestive Diseases. 2003, 4: 132-135.

Wong W.M., Lai K.C., Lam K.F., Hui W.M., Hu H.C., Lam C.L.K., Xia H.H.X., Huang J., Chan C.K., Lam S.K. and Wong B.C.Y., Prevalence, Clinical Spectrum and Health Care Utilization of Gastro-Oesophageal Reflux Disease in a Chinese Population: a Population-Based Study, Alimentary Pharmacology and Therapeutics. 2003, 18(6): 595-604.

Xia H.H.X. and Wong B.C.Y., Nitric Oxide in Helicobacter pylori-Induced Apoptosis and its Significance in Gastric Carcinogenesis, Journal of Gastroenterology and Hepatology. 2003, 18(11): 1227-30.

Xia H.H.X., Yang Y. and Wong B.C.Y., Relationship between Helicobacter pylori infection and gastro-esophageal reflux disease., Chinese Journal of Digestive Diseases . 2004, 5: 1-6.

Yang Y., Lin M.C., Ching Y.P., Lam S.K., Xia H.H.X., Tu S., Zou B., Wang J., Li G., He H., Gu Q., Peng J., Kung H. and Wong B.C.Y., FHL2 As a Co-Factor of XAF1 in the Induction of Apoptosis, Gastroenterology. 2004, 126 (4 Suppl 2): S938.

Researcher : Xu A

Project Title:	The molecular mechanisms controlling the gene expression of fat-derived antidiabetic hormone adiponectin
Investigator(s):	Dr. Xu A.M., Prof. Lam K.S.L.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	01/2003
Completion Date:	12/2003

Abstract:

To elucidate the transcriptional events that determine the adipocyte-specific expression of adiponectin gene; to identify the obesity-responsive element (ORE) and nuclear factors that mediate obesity-linked repression of adiponectin gene expression; to elucidate the signal transduction pathways and transcriptional events involved in regulation of adiponectin gene by hormones and nutritional changes.

Project Title:	Adiponectin as a novel hormone for the treatment of diabetes and obesity-related metabolic syndromes
Investigator(s):	Dr. Xu A.M., Prof. Lam K.S.L.
Department:	Medicine
Source(s) of Funding:	RGC Projects (Block Grant Funded)
Start Date:	07/2003

Abstract:

To explore the physiological functions and the clinical applications of adiponectin.

Project Title:	Hepatocytes as a major therapeutic target for the anti-diabetic and anti-inflammatory hormone adiponectin
Investigator(s):	Dr. Xu A.M., Prof. Lam K.S.L.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	02/2004

Abstract:

To define the roles of two recently identified adiponectin receptors and several intracellular signaling pathways (AMP-activated protein kinase, P38 MAP kinase and PPAR_a) in mediating the multiple biological actions of adiponectin in hepatocytes; to investigate how phosphorylation modulates the activities of adiponectin receptors; to identify the membrane-proximal downstream signaling molecules of adiponectin receptors in hepatocytes.

List of Research Outputs

Chow W.S., Tan K.C.B., Xu A., Ai V.H.G., Tam S.C.F. and Lam K.S.L., Hypoadiponectinemia is associated with endothelial dysfunction, 5th Annual Scientific Meeting of Hong Kong Society of Endocrinology, Metabolism and Reproduction, October 2003, Hong Kong. 2003.

Chow W.S., Tan K.C.B., Xu A., Lam C.W., Ai V.H.G., Tam S.C.F. and Lam K.S.L., Hypoadiponectinemia is associated with impaired endothelial vasomotor function, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Dan Q., Xu A., Cheng K.Y., Xu J. and Lam K.S.L., Adiponectin suppresses the proliferation of human aortic smooth muscle cells induced by advanced glycation and end products, The 3rd International Huaxia Congress of Endocrinology, May 25 – 28, 2004, Shanghai, China. 2004.

Lam K.S.L., Xu A., Wat N.M.S., Tso A.W.K. and Ip M.S.M., Obesity as the key player in the Metabolic Syndrome, 13th International Symposium on Atherosclerosis, September 28 – October 2, 2003, Kyoto, Japan.. 2003.

Lam K.S.L., Xu A., Wat N.M.S., Tso A.W.K. and Ip M.S.M., Obesity as the key player in the metabolic syndrome, International Congress Series. 2004, 1262: 542-5.

Lee K.K., Xu A., Tan K.C.B., Wong L.C., Tiu S.C., Tam S.C.F. and Lam K.S.L., Serum adiponectin is reduced in acromegaly and normalized after correction of growth hormone excess, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Rong R., Tao A.W.K., Xu A., Cheung G.C.N., Yeung C., Cheung B.M.Y. and Lam K.S.L., Hypoadiponectinaemia is a risk factor of the metabolic syndrome, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Rong R., Xu A., Cheung B.M.Y., Cheung G.C.N. and Lam K.S.L., Identification of three novel missense mutations of the human melanocortin-4 receptor gene in a Chinese obesity population, ENDO 2004, New Orleans, USA, 16-19 June 2004.

Tan K.C.B., Xu A., Chow W.S., Ai V.H.G., Tam S.C.F. and Lam K.S.L., Association between adiponectin and endothelial dysfunction, XIIIth International Symposium on Atherosclerosis, Sep 28-oct 2, 2003, Kyoto, Japan. European Atherosclerosis Society, 2003, 1P-0167.

Tan K.C.B., Xu A., Shiu S.W.M. and Lam K.S.L., Association between adiponectin and hepatic lipase activity, American Diabetes Association 64th Scientific Sessions, Orlando , June 2004.

Tan K.C.B., Xu A., Chow W.S., Lam C.W., Ai V.H.G. and Tam S.C.F., Hypoadiponectinemia is associated with impaired endothelial vasomotor function, Journal of Clinical Endocrinology and Metabablism. 2004, 89: 765-769.

Tan K.C.B., Xu A., Chow W.S., Ai V.H.G., Tam S.C.F. and Lam K.S.L., Hypoadiponectinemia is associated with impaired endothelium-dependent vasodilatation, Journal of Endocrinology and Metabolism. 2004, 89: 765-9.

Tao A.W.K., Wat N.M.S., Xu A., Rong R., Cheng K.Y., Fong H.Y., Janus E.D. and Lam K.S.L., The adiponectin gene T45G polymorphism is associated with central obesity and glucose intolerance in southern Chinese, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Xu A., Yin S., Wong L.C., Chan K.W. and Lam K.S.L., Adiponectin ameliorates dyslipidemia induced by the human immunodeficiency virus protease inhibitor ritonavir in mice, Endocrinology . 2004, 145: 487-94.

Xu A., Wong L.C. and Lam K.S.L., Growth hormone enhances adiponectin gene expression via P38 MAP kinase pathway in 3T3-L1 adipocytes, ENDO 2004, New Orleans, USA, 16-19 June 2004.. 2004.

Xu A., Lam K.S.L., Wang Y., Choi L.U.K. and Cooper G...S., Proteomic Analysis Of Adipocyte Differentiation: Evidence That Alpha2 Macroglobulin Is Involved In The Adipose Conversion Of 3t3 L1 Preadipocytes, Proteomics. 2004, 4: 1840-1848.

Xu A., Wong W., Wang Y., Cooper G.J.S. and Lam K.S.L., Proteomic and functional characterization of endogenous adiponectin purified from fetal bovine serum, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Xu A., Yin S., Wong L.C., Chan K.W. and Lam K.S.L., The fat-derived hormone adiponectin ameliorates dyslipidemia induced by HIV protease inhibitors, 13th International Symposium on Atherosclerosis, September 28 – October 2, 2003, Kyoto, Japan. 2003.

Xu A., Yin S., Wong L.C., Chan K.W. and Lam K.S.L., The fat-derived hormone adiponectin ameliorates dyslipidemia induced by HIV protease inhibitors, 15th Annual Scientific Meeting of Hong Kong Society of Endocrinology, Metabolism and Reproduction, October 2003, Hong Kong. 2003.

Xu A., Yiu S., Wong L.Y.F., Chan W.K. and Lam K.S.L., The fat-derived hormone adiponectin ameliorates dyslipidemia induced by HIV protease inhibitors, XIII International Symposium on Atherosclerosis, September 28-October 2, 2003, Kyoto, Japan . The European Atherosclerosis Society, 2003, Sep 2003: 242 (3P-0821*).

Yin S., Pan C., Xu A. and Lam K.S.L., C/EBP play an important role in adiponectin gene expression, The 3rd International Huaxia Congress of Endocrinology, May 25 – 28, 2004, Shanghai, China. 2004.

Researcher : Xu J

List of Research Outputs

Dan Q., Xu A., Cheng K.Y., Xu J. and Lam K.S.L., Adiponectin suppresses the proliferation of human aortic smooth muscle cells induced by advanced glycation and end products, The 3rd International Huaxia Congress of Endocrinology, May 25 – 28, 2004, Shanghai, China. 2004.

Tso A.W.K., Rong R., Lo C.Y., Tan K.C.B., Tiu S.C., Wat N.M.S., Xu J., Villablanca A., Larsson C., Teh B.T. and Lam K.S.L., Multiple endocrine neoplasia type 1 (MEN 1): genetic and clinical analysis in Southern Chinese, Clinical Endocrinology. 2003, 59: 129-35.

Xu J., Dan Q., Chan V.N.Y., Wat N.M.S., Tam S.C.F., Tiu S.C., Lee K.F., Siu S.C., Tsang M.W., Fung L.M., Chan K.W. and Lam K.S.L., Genetic and clinical characteristics of maturity-onset diabetes of the young in Chinese patient, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Researcher : Yam LYC

List of Research Outputs

Chan M.M.W., Seto W.H., Sung J.J., Lai T.S.T., Yee W., Yam L.Y.C., Tsang K.W.T., Ip M.S.M., Lam W.K. and Lai K.N., Severe Acute Respiratory Syndrome: Patients Were Epidemiologically Linked, British Medical Journal. 2003, 326: 1393.

Mok W.Y.W., Lam C.L.K., Lam B., Cheung M.T., Yam L.Y.C. and Ip M.S.M., A Chinese version of the Sleep Apnea Quality of Life Index : reliability, validity and responsiveness, Journal of Clinical Epidemiology. 2004, 57(5): 470-478.

Researcher : Yan CPK

List of Research Outputs

Ho J.C.M., Lam W.K., Yan C.P.K., Ip S., Wong M., Lam J., Wang J., Lam C.L., Lam B., Chan M.M.W., Ip M.S.M. and Tsang K.W.T., A phase II study of vinorelbine monotherapy in the treatment of advanced nob-small cell lung cancer in the elderly, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-06.

Tsang K.W.T., Tipoe G.L., Sun J.Z., Mak J.C.W., Leung Y.H., Yan C.P.K., Ko K.W., Ooi C.G.C., Ho P.L., Ho J.C.M. and Lam W.K., Central microtubular ciliary defects are of clinical significance in bronchiectasis, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia. 2003, Abstract Book PP6-20: p.199.

Tsang K.W.T., Tipoe G.L., Sun J.Z., Mak J.C.W., Leung Y.H., Yan C.P.K., Ko K.W., Ooi C.G.C., Ho P.L., Ho J.C.M. and Lam W.K., Ciliary central microtubular orientation is of no clinical significance in bronchiectasis, 8th Asian Pacific Society of Respirology Congress, Kuala Lumpur, Malaysia. 2003, Abstract Book PP6-21: p.200.

Tsang K.W.T., Tipoe G.L., Sun J.Z., Mak J.C.W., Leung Y.H., Yan C.P.K., Ko K.W., Ooi C.G.C. and Lam W.K., Clinical significance of ciliary abnormalities in bronchiectasis, European Respiratory Journal. 2003, suppl 22(45): P559.

Researcher : Yang Y

List of Research Outputs

Tu S., Jiang X., Lin M.C., Cui J., Yang Y., Lum C.T., Zou B., Zhu Y.B., Jiang S.H., Wong W.M., Chan O.O., Yuen M.F., Lam S.K., Kung H. and Wong B.C.Y., Suppression of Survivin Expression Inhibits in vivo Tumorigenicity and Angiogenesis in Gastric Cancer, Cancer Research. 2003, 63(22): 7724-7732.

Wang J., Gu Q., Xia H.H.X., Tu S., Peng J., Yang Y., Zou B., Lin M.C., Kung H., Lam S.K. and Wong B.C.Y., JNK1 Up-Regulates the Expression of XIAP-Associated Factor 1 (XAF1) by a P53-Dependent Pathway in Gastrointestinal Cancer, Gastroenterology. 2004, 126 (4 Suppl 2): M946.

Xia H.H.X., Yang Y. and Wong B.C.Y., Relationship between Helicobacter pylori infection and gastro-esophageal reflux disease., Chinese Journal of Digestive Diseases . 2004, 5: 1-6.

Yang Y., Lin M.C., Ching Y.P., Lam S.K., Xia H.H.X., Tu S., Zou B., Wang J., Li G., He H., Gu Q., Peng J., Kung H. and Wong B.C.Y., FHL2 As a Co-Factor of XAF1 in the Induction of Apoptosis, Gastroenterology. 2004, 126 (4 Suppl 2): S938.

Zou B., Lin M.C., Lam S.K., Tu S., Yang Y., Wang J., He H., Peng J., Kung H. and Wong B.C.Y., Hypermethylation Status Around Exon 1 of XIAP-Associated Factor 1 in Human Gastric and Colon Cancer Cell Lines, Gastroenterology. 2004, 126 (4 Suppl 2): T981.

Researcher : Yeung JSL

List of Research Outputs

Mok T.M.Y., Yeung J.S.L., Jin O., Chan W.K., Lo Y. and Lau W.C.S., Anti-beta2 glycoprotein I antibodies facilitates phagocytosis of apoptotic neutrophils in patients with systemic lupus erythematosus, The Hong Kong Practitioner. 2003, 9(Suppl 1): 65.

Mok T.M.Y., Yeung J.S.L., Chan W.K., Leung P.Y., Lo Y. and Lau W.C.S., Sex hormones and apoptosis and immunoglobulin production in systemic lupus erythematosus, The Hong Kong Practitioner. 2003, 9(Suppl 1): 66.

Researcher : Yin S

List of Research Outputs

Dan Q., Yin S., Chung S.K., Chung S.S.M. and Lam K.S.L., Interaction between the polyol pathway and non-enzymatic glycation on aortic smooth muscle cell migration and monocyte adhesion in a transgenic mouse model, 13th International Symposium on Atherosclerosis, September 28 – October 2, 2003, Kyoto, Japan. 2003.

Dan Q., Yin S., Wong L.C., Chung S.K., Chung S.S.M. and Lam K.S.L., Interaction between the polyol pathway and non-enzymatic glycation on aortic smooth muscle cell migration and monocyte adhesion in a transgenic mouse model, 15th Annual Scientific Meeting of Hong Kong Society of Endocrinology, Metabolism and Reproduction, October 2003, Hong Kon. 2003.

Dan Q., Yin S., Wong L.C., Chung S.K., Chung S.S.M. and Lam K.S.L., Interaction between the polyol pathway and non-enzymatic glycation on aortic smooth muscle cell migration and monocyte adhesion in a transgenic mouse model, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong, 7-8 February 2004.

Dan Q., Yin S., Wong L.C., Chung S.K., Chung S.S.M. and Lam K.S.L., Interaction between the polyol pathway and non-enzymatic glycation on aortic smooth muscle cell mirgration and moncyte adhesion in a transgenic mouse model, XIIIth International Symposium on Atherosclerosis, Sep 28-Oct 2, 2003, Kyoto, Japan. European Atherosclerosis Society, 2003, 1P-0137.

Lam K.S.L., Dan Q., Yin S., Wong L.C., Chung S.K. and Chung S.S.M., Interaction between non-enzymatic glycation and the polyol pathway on mesangial cell gene expression in an aldose reductase transgenic mouse model, The 18th International Diabetes Federation Congress, August 24-29, 2003, Paris, France. 2003.

Xu A., Yin S., Wong L.C., Chan K.W. and Lam K.S.L., Adiponectin ameliorates dyslipidemia induced by the human immunodeficiency virus protease inhibitor ritonavir in mice, Endocrinology . 2004, 145: 487-94.

Xu A., Yin S., Wong L.C., Chan K.W. and Lam K.S.L., The fat-derived hormone adiponectin ameliorates dyslipidemia induced by HIV protease inhibitors, 13th International Symposium on Atherosclerosis, September 28 – October 2, 2003, Kyoto, Japan. 2003.

Xu A., Yin S., Wong L.C., Chan K.W. and Lam K.S.L., The fat-derived hormone adiponectin ameliorates dyslipidemia induced by HIV protease inhibitors, 15th Annual Scientific Meeting of Hong Kong Society of Endocrinology, Metabolism and Reproduction, October 2003, Hong Kong. 2003.

Yin S., Pan C., Xu A. and Lam K.S.L., C/EBP play an important role in adiponectin gene expression, The 3rd International Huaxia Congress of Endocrinology, May 25 – 28, 2004, Shanghai, China. 2004.

Researcher : Yip PC

List of Research Outputs

Chan V.N.Y., Au P., Yip P.C. and Chan T.K., A New Cross-over Region For Hemoglobin-Lepore-Hollandia, Haematologica. 2004, 89: 610-611.

Researcher : Yiu K

List of Research Outputs

Tse H.F. and Yiu K., Deep vein thrombosis demonstrated by contrast enhanced helical computer tomorgraphic venography, Heart. 2004, 90(3): 251.

Researcher : Yu CM

List of Research Outputs

Yu C.M., Lai K.W.H., Li P.S., Lam K.Y., Leung J.C.K. and Lai K.N., Normalization of renal aquaporin-2 water channel expression by fosinopril, valsartan, and combination therapy in congestive heart failure: a new mechanism of action, Journal of Molecular and Cellular Cardiology. 2004, 36: 445-453.

Researcher : Yu KMC

List of Research Outputs

Tse H.F., Yu K.M.C., Paul V.E., Boriani G., Schuchert A., Del Ojo J.L., Malinowski K., Blanc J.J. and Lau C.P., Effect of left ventricular function on long-term left ventricular pacing and sensing threshold., J Interv Card Electrophysiol. 2003, 9 (1): 21-4.

Researcher : Yu YL

List of Research Outputs

Yu Y.L., Fong K.Y., Ho S.L. and Cheung R.T.F., [Total of 18 chapters- contribution about 1/4: preface, four chapters and 2 half-chapters], Neurology in Practice. Hong Kong, Hong Kong University Press, 2003, 3rd edition.

Researcher : Yuan H

List of Research Outputs

Pang A.W.K., Yuen M.F., Yuan H., Lai C.L. and Kwong Y.L., Real-time quantification of hepatitis B virus core-promoter and pre-core mutants during hepatitis E antigen seroconversion, Journal of Hepatology. 2004, 40: 1008-1017.

Yuan H., Yuen M.F., Wong D.K.H., Sum S.M., Doutreloigne J., Sablon E. and Lai C.L., Determinants for the Occurrence of Acute Exacerbation after HBeAg Seroclearance in Chinese Patients, Hepatology. 2003, 38, No. 4, Suppl. 1: 623A.

Yuen M.F., Kato T., Mizokami M., Chan O.O., Yuen J.C.H., Yuan H., Wong D.K.H., Sum S.M., Ng I.O.L., Fan S.T. and Lai C.L., Clinical outcome and virologic profiles of severe hepatitis B exacerbation due to YMDD mutations, Journal of Hepatology. 2003, 39(5): 850-855.

Yuen M.F., Wong D.K.H., Sablon E., Tse E.W.C., Ng I.O.L., Yuan H., Siu C.W., Sander T.J., Bourne E.J., Hall J.G., Condreay L.D. and Lai C.L., HBsAg seroclearance in chronic hepatitis B in the Chinese: Virological, histological, and clinical aspects, Hepatology. 2004, 39(6): 1694-1701.

Yuen M.F., Wong D.K.H., Sablon E., Yuan H., Sum S.M., Hui C.K., Chan O.O., Wong B.C.Y. and Lai C.L., Hepatitis B Virus Genotypes B and C Do Not Affect The Antiviral Response To Lamivudine, Antiviral Therapy. 2003, 8: 531-534.

Yuen M.F., Wong D.K.H., Sablon E., Yuan H., Sum S.M., Hui C.K., Wong B.C.Y. and Lai C.L., Hepatitis B Virus Genotypes B and C Do Not Affect the Anti-viral Response to Lamivudine, Hepatology. 2003, 38, No. 4, Suppl. 1: 723A.

Yuen M.F., Sablon E., Wong K.H.D., Yuan H., Wong B.C.Y., Chan O.O. and Lai C.L., Role of Hepatitis B Virus Genotypes in Chronic Hepatitis B Exacerbation, Clinical Infectious Diseases. 2003, 37: 593-7.

Researcher : Yuen JCH

List of Research Outputs

Pang R.W.C., Yuen J.C.H., Yuen M.F., Lai C.L., Lee K.W., Man K., Poon R.T.P., Fan S.T., Wong C.M., Ng I.O.L., Kwong Y.L. and Tse E.W.C., PIN1 over-expression and β-catenin gene mutations are distinct oncogenic events in human hepatocellular carcinoma, Oncogene. 2004, 23(23): 4182-6.

Yuen M.F., Kato T., Mizokami M., Chan O.O., Yuen J.C.H., Yuan H., Wong D.K.H., Sum S.M., Ng I.O.L., Fan S.T. and Lai C.L., Clinical outcome and virologic profiles of severe hepatitis B exacerbation due to YMDD mutations, Journal of Hepatology. 2003, 39(5): 850-855.

Researcher : Yuen MF

List of Research Outputs

Chan O.O., Yuen M.F., Lam C.M., Fong C.Y., Wong B.C.Y. and Lai C.L., Prevalence and Characteristics of Familial Hepatocellular Carcinoma Caused by Chronic Hepatitis B Infection in Hong Kong, Alimentary Pharmacology and Therapeutics. 2004, 19(4): 401-6.

Chan O.O., Peng J., Lam S.K., Hui W.M., Wong R.W.M., Yuen M.F., Kwong Y.L., Rashid A. and Wong B.C.Y., Reveral of E-Cadherin Promoter Hypermethylation Status after Helicobacter pylori Eradication, Gastroenterology. 2004, 126 (4 Suppl 2): 333.

Hui C.K., Lai K.C., Yuen M.F., Ng M.M.T., Chan C.K., Hu H.C., Wong R.W.M., Lai C.L. and Wong B.C.Y., Does the Addition of Endoscopic Sphincterotomy to Stent Insertion Improve Drainage of the Bile Duct in Acute Suppurative Cholangitis?, Gastrointestinal Endoscopy. 2003, 58(4): 500-4.

Hui C.K., Yuen M.F., Wong W.M., Lam S.K. and Lai C.L., Mirtazapine Induced Hepatotoxicity, Journal of Clinical Gastroenterology. 2003, 35(3): 270-271.

Hui C.K., Liu C.L., Lai K.C., Chan S.C., Hu H.C., Wong R.W.M., Cheung W.W., Ng M.M.T., Yuen M.F., Chan O.O., Lo C.M., Fan S.T. and Wong B.C.Y., Outcome of emergency ERCP for acute cholangitis in patients 90 years of age and older, Alimentary Pharmacology and Therapeutics. 2004, 19(11): 1153-1158.

Hui C.K., Lai K.C., Yuen M.F., Wong R.W.M., Chan O.O., Ng M.M.T., Chan C.K., Cheung W.W., Lam S.K., Lai C.L. and Wong B.C.Y., The Role of Cholecystectomy in Reducing Recurrent Gallstone Pancreatitis, Endoscopy. 2004, 36(3): 206-11.

Lai C.L., Ratziu V., Yuen M.F. and Poynard T., Viral Hepatitis B, Lancet. 2003, 362: 2089-2094.

Lo C.M., Cheung S.T., Lau G., Yuen M.F., Liu C.L., Fan S.T. and Wong J., Significance of hepatitis B virus genotype in liver transplantation for chronic hepatitis B (Invited Lecture), Digestive Disease Week, New Orleans, U.S.A., 15-20 May 2004.

Lo C.M., Cheung S.T., Lau G., Yuen M.F., Liu C.L., Fan S.T. and Wong J., Significance of hepatitis B virus genotype in liver transplantation for chronic hepatitis B (Invited Lecture), The 5th Joint Annual Meeting of the American Society of Transplant Surgeons and the American Society of Transplantation, Boston, U.S.A., 14-19 May 2004.

Pang A.W.K., Yuen M.F., Yuan H., Lai C.L. and Kwong Y.L., Real-time quantification of hepatitis B virus core-promoter and pre-core mutants during hepatitis E antigen seroconversion, Journal of Hepatology. 2004, 40: 1008-1017.

Pang R., Yuen J., Yuen M.F., Lai C.L., Lee K.W., Man K., Poon R.T.P., Fan S.T., Wong C.M., Ng I.O.L., Kwong Y.L. and Tse E., PIN1 over-expression and b-catenin gene mutations are distinct oncologic events in human hepatocarcinogenesis (Oral Presentation), The 8th Research Postgraduate Symposium, The University of Hong Kong, Hong Kong, 13 December 2003.

Pang R.W.C., Yuen J.C.H., Yuen M.F., Lai C.L., Lee K.W., Man K., Poon R.T.P., Fan S.T., Wong C.M., Ng I.O.L., Kwong Y.L. and Tse E.W.C., PIN1 over-expression and β-catenin gene mutations are distinct oncogenic events in human hepatocellular carcinoma, Oncogene. 2004, 23(23): 4182-6.

Poynard T., Yuen M.F., Ratziu V. and Lai C.L., Viral Hepatitis C, Lancet. 2003, 362: 2095-2100.

Tu S., Jiang X., Lin M.C., Cui J., Yang Y., Lum C.T., Zou B., Zhu Y.B., Jiang S.H., Wong W.M., Chan O.O., Yuen M.F., Lam S.K., Kung H. and Wong B.C.Y., Suppression of Survivin Expression Inhibits in vivo Tumorigenicity and Angiogenesis in Gastric Cancer, Cancer Research. 2003, 63(22): 7724-7732.

Wong B.C.Y., Jiang X., Lin M.C., Tu S., Cui J., Jiang S.H., Wong R.W.M., Yuen M.F., Lam S.K. and Kung H., Cyclooxygenase-2 Inhibitor (SC-236) Suppresses Activator Protein-1 through c-Jun NH2-Terminal Kinase, Gastroenterology. 2004, 126: 136-147.

Wong W.M., Gu Q., Wang W., Fung F.M.Y., Berg D.E., Lai K.C., Xia H.H.X., Hu H.C., Chan C.K., Chan O.O., Yuen M.F., Hui C.K., Lam S.K. and Wong B.C.Y., Effects of Primary Metronidazole and Clarithromycin Resistance to Helicobacter pylori on Omeprazole, Metronidazole, and Clarithromycin Triple-Therapy Regimen in a Region with High Rates of Metronidazole Resistance, Clinical Infectious Diseases. 2003, 37(7): 882-9.

Wong W.M., Lam S.K., Tong S.M., Cheung K.L., Tang V.S.Y., Xia H.H.X., Lai K.C., Hu H.C., Chan C.K., Yuen M.F., Chan O.O. and Wong B.C.Y., Evaluation of a Rapid Stool Antigen Test for the Diagnosis of Helicobacter pylori Infection in Chinese Patients, Chinese Journal of Digestive Diseases. 2003, 4: 132-135.

Yuan H., Yuen M.F., Wong D.K.H., Sum S.M., Doutreloigne J., Sablon E. and Lai C.L., Determinants for the Occurrence of Acute Exacerbation after HBeAg Seroclearance in Chinese Patients, Hepatology. 2003, 38, No. 4, Suppl. 1: 623A.

Yuen M.F., Wong D.K.H., Sablon E., Tse E.W.C., Ng I.O.L., Yuan H., Siu C.W., Sander T.J., Bourne E.J., Hall J.G., Condreay L.D. and Lai C.L., HBsAg seroclearance in chronic hepatitis B in the Chinese: Virological, histological, and clinical aspects, Hepatology. 2004, 39(6): 1694-1701.

Yuen M.F., Tanaka Y. and Lai C.L., Hepatitis B Genotypes in Chronic Hepatitis B And Lamivudine Therapy, Intervirology. 2003, 46: 373-376.

Yuen M.F., Wong D.K.H., Sablon E., Yuan H., Sum S.M., Hui C.K., Chan O.O., Wong B.C.Y. and Lai C.L., Hepatitis B Virus Genotypes B and C Do Not Affect The Antiviral Response To Lamivudine, Antiviral Therapy. 2003, 8: 531-534.

Yuen M.F., Wong D.K.H., Sablon E., Yuan H., Sum S.M., Hui C.K., Wong B.C.Y. and Lai C.L., Hepatitis B Virus Genotypes B and C Do Not Affect the Anti-viral Response to Lamivudine, Hepatology. 2003, 38, No. 4, Suppl. 1: 723A.

Yuen M.F., Sablon E., Wong K.H.D., Yuan H., Wong B.C.Y., Chan O.O. and Lai C.L., Role of Hepatitis B Virus Genotypes in Chronic Hepatitis B Exacerbation, Clinical Infectious Diseases. 2003, 37: 593-7.

Yuen M.F. and Lai C.L., Screening For Hepatocellular Carcinoma: Survival Benefit And Cost-effectiveness, Annals of Oncology. 2003, 14: 1463-1467.

Yuen M.F. and Lai C.L., Specific Considerations In The Design Of Hepatitis B Virus Clinical Studies In The Far East, In: Humana Press, Totowa, New Jersey, USA, Ed. Hamatake RK, Lau JYN., Hepatitis B and D Protocols. Volume II: Immunology, Model Systems and Clinical Studies. Humana Press Inc., 2004, II: 457-464.

Researcher : Yung SSY

Project Title:	Effects of anti-DNA antibodies on the synthesis of hyaluronan by human mesangial cells
Investigator(s):	Dr. Yung S.S.Y., Prof. Chan D.T.M.
Department:	Medicine
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	09/2001

Abstract:

To determine the concentration and molecular weight of circulating HA in relation to disease activity in diffuse proliferative lupus nephritis; to examine histologically the expression of HA, the enzymes for HA synthesis (i.e. HAS and uridine diphosphoglucose dehydrogenase, UDPGD), HA receptor CD44, and inflammatory cytokines IL-Ib and TNF-a in renal biopsies of diffuse proliferatve lupus nephritis; to exmine the effects of anti-DNA antibodies on HA synthesis and degradation by HMC; to determine the effects of anti-DNA antibodies on the expression of UDPGD, HAS, CD44 and the above cytokines in cultured HMC.

Project Title:	The effects of amino acid-based and glucose-based peritoneal dialysis (PD) fluids on the viability, ultrastructure, and inflammatory response of human peritoneal mesothelial cell
Investigator(s):	Dr. Yung S.S.Y., Prof. Chan D.T.M.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	10/2002
Completion Date:	09/2003

Abstract:

To assay the pro-inflammatory cytokines/marker interleukin-1b (IL-1b), interleukin-6 (IL-6), and hyaluronan (HA) respectively in spent (i.e. drained) amino acid- and glucose-based PD fluids, (ii) to examine the viability of human peritoneal mesothelial cells (HPMC) in the presence of either spent amino acid- or glucose-based PDF, (iii) to examine the effects of these PD fluids on HPMC ultrastructure, and (iv) to determine IL-1b, IL-6, and HA synthase I, II and III transcription and translation in HPMC under these conditions.

Project Title:	The role of hyaluronan and cytoskeletal proteins in mediating human peritoneal mesothelial cell transdifferentiation during peritoneal dialysis
Investigator(s):	Dr. Yung S.S.Y., Prof. Chan D.T.M.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	02/2004

Abstract:

To isolate human peritoneal mesothelial cells (HPMC) in spent PD fluid obtained from patients on long-term PD, and to determine the ratio of non-transdifferentiated and transdifferentiated mesothelial cells. The cell morphology and cytoskeleton will be compared with normal HPMC isolated from omental specimens from non PD patients during abdominal surgery; to assess hyaluronan synthesis (at transcription and translation) during mesothelial cell transformation; to determine concomitant changes in the cytoskeleton (vimentin, cytokeratin, and a-smooth muscle actin), and epithelial markers (E-cadherin , occludin ZO-1).

List of Research Outputs

Chan D.T.M., Tsang R.C.W., Leung J.K.H. and Yung S.S.Y., Modulation of hyaluronan synthesis in human mesangial cells after stimulation with Anti-DNA antibodies from patients with lupus nephritis, Journal of American Society of Nephrology. 2003, 14: 594A.

Yung S.S.Y., Hausser H., Thomas G., Schaefer L., Kresse H. and Davies M., Catabolism of newly synthesized decorin in vitro by human peritoneal mesothelial cells, Peritoneal Dialysis International. 2004, 24: 147.

Yung S.S.Y., Leung J.K.H., Liu Z.H., Li L.S. and Chan D.T.M., Emodin abrogates peritoneal dialysate induction of pro-inflammatory/fibrotic mediators and morphological changes in human peritoneal mesothelial cells, 9th Medical Reserach Conference. 7-8 February. 2004, Abstract NP-01.

Yung S.S.Y., Leung J.K.H., Liu Z.H., Li L.S. and Chan D.T.M., Emodin abrogates peritoneal dialysis fluid induction of matrix protein synthesis and morphologic changes in human peritoneal mesothelial cells, Journal of American Society of Nephrology. 2003, 14: 645A.

Yung S.S.Y. and Chan D.T.M., Preventing peritoneal fibrosis - Insights from the laboratory, Peritoneal Dialysis International. 2003, 23: S37-S41.

Yung S.S.Y., Chen X., Tsang R.C.W., Zhang Q. and Chan D.T.M., Reduction of perlecan synthesis and induction of TGF-beta 1 in human peritoneal mesothelial cells due to high glucose concentration - implication in peritoneal dialysis, Journal of American Society of Nephrology. 2004, May 15 (5): 1178-1188.

Zhang Q., Yung S.S.Y., Leung J.K.H. and Chan C.Y., Alpha-actinin and F-actin expression is modulated by elevated glucose concentration in human mesangial cells, 9th Medical Research Conference. 7-8 February . 2004, Abstract NP-05.

Researcher : Zhang JCL

Project Title:	In vitro characterization of the 5' flanking region of the SM22b gene
Investigator(s):	Dr. Zhang J.C.J.L., Dr. Parmacek M.S.
Department:	Medicine
Source(s) of Funding:	Block Grant Earmarked for Research
Start Date:	01/2003
Completion Date:	12/2003

Abstract:

To understand the transcriptional regulation of SM22b in cardiovascular development; to define the promoter region of SM22b gene.

Project Title:	Functional analysis of SM22b by tissue-specific targeted deletion in mice
Investigator(s):	Dr. Zhang J.C.J.L., Prof. Cheah K.S.E., Dr. Feil R., Prof. Lau C.P., Dr. Parmacek M.S.
Department:	Medicine
Source(s) of Funding:	Hong Kong Research Grants Council Competitive Earmarked Research Grants
Start Date:	09/2003

Abstract:

To determine the general role of SM22b in a cell; to understand the specific role of SM22b in cardiovascular development.

Project Title:	Functional analysis of SM22b by tissue-specific targeted deletion in mice
Investigator(s):	Dr. Zhang J.C.J.L., Prof. Cheah K.S.E., Dr. Feil R., Prof. Lau C.P., Dr. Parmacek M.S.
Department:	Medicine
Source(s) of Funding:	RGC Projects (Block Grant Funded)
Start Date:	09/2003

Abstract:

To determine the general role of SM22b in a cell; to understand the specific role of SM22b in cardiovascular development.

List of Research Outputs

Chan K.W., Fong S.W., Mak H.S., Chan C.H., Zhang J.C.L. and Chan S.Y., Transgenic Approaches to Study the Function of NAP79, a new member of Nucleosome Assembly Proteins, 2004 Sir Edward Youde Memorial Fund Postgraduate Conference, Model Organism Research and Human Diseases, HK, 14-15 June 2004. 33.

Fong S.W., Chan K.W., Zhang J.C.L., Higgins D.A., Liang Y. and Chan S.Y., Cardiac expression of NAP79, a new membeer of Nucleosome Assembly Proteins, 2004 Sir Edward Youde Memorial Fund Postgraduate Conference, Model Organism Research and Human Diseases, HK, 14-15 June 2004. 34.

Researcher : Zhang Q

List of Research Outputs

Yung S.S.Y., Chen X., Tsang R.C.W., Zhang Q. and Chan D.T.M., Reduction of perlecan synthesis and induction of TGF-beta 1 in human peritoneal mesothelial cells due to high glucose concentration - implication in peritoneal dialysis, Journal of American Society of Nephrology. 2004, May 15 (5): 1178-1188.

Zhang Q., Yung S.S.Y., Leung J.K.H. and Chan C.Y., Alpha-actinin and F-actin expression is modulated by elevated glucose concentration in human mesangial cells, 9th Medical Research Conference. 7-8 February . 2004, Abstract NP-05.

Researcher : Zheng G

List of Research Outputs

Huang J., Zheng G., IRVINE E. .J. and Karlberg J.P.E., Assessing heterogeneity in meta-analyses of Helicobacter pylori infection-related clinical studies: a critical appraisal, Chinese Journal of Digestive Diseases. 2004, 5: 126-133.

Wang W., Huang J., Zheng G., Lam S.K., Karlberg J.P.E. and Wong B.C.Y., Non-Steroidal Anti-Inflammatory Drug Use and the Risk of Gastric Cancer: A Systematic Review and Meta-Analysis, Journal of the National Cancer Institute. 2003, 95(23): 1784-1791.

Researcher : Zheng L

List of Research Outputs

Ho J.C.M., Tipoe G.L., Zheng L., Leung T.M., Tsang K.W.T., Shum D.K.Y., Lau W.C.S., Mak J.C.W., Lam W.K. and Ip M.S.M., In vitro study of regulation of IL-6 production in bronchiectasis, Respiratory Medicine. 2004, 98: 334-341.

Researcher : Zheng T

List of Research Outputs

Wong B.C.Y., Lam S.K., Wong R.W.M., Chen J.S., Zheng T., Feng R., Lai K.C., Hu H.C., Yuen S.T., Leung S.Y., Fong D.Y.T., Ho J.C.Y., Ching C.K. and Chen J.S., Helicobacter pylori Eradication to Prevent Gastric Cancer in a High-Risk Region of China: a Randomized Controlled Trial, The Journal of American Medical Association. 2004, 291(2): 187-194.

Wong B.C.Y., Lam S.K., Wong R.W.M., Chen J.S., Zheng T., Feng R., Lai K.C., Hu H.C., Yuen S.T., Leung S.Y., Fong D.Y.T., Ho J.W.C. and Ching C.K., Helicobacter pylori eradication to prevent gastric cancer in a high-risk region in China: A randomized controlled trial, JAMA. 2004, 291(2): 187-194.

Researcher : Zou B

List of Research Outputs

Tu S., Jiang X., Lin M.C., Cui J., Yang Y., Lum C.T., Zou B., Zhu Y.B., Jiang S.H., Wong W.M., Chan O.O., Yuen M.F., Lam S.K., Kung H. and Wong B.C.Y., Suppression of Survivin Expression Inhibits in vivo Tumorigenicity and Angiogenesis in Gastric Cancer, Cancer Research. 2003, 63(22): 7724-7732.

Wang J., Gu Q., Xia H.H.X., Tu S., Peng J., Yang Y., Zou B., Lin M.C., Kung H., Lam S.K. and Wong B.C.Y., JNK1 Up-Regulates the Expression of XIAP-Associated Factor 1 (XAF1) by a P53-Dependent Pathway in Gastrointestinal Cancer, Gastroenterology. 2004, 126 (4 Suppl 2): M946.

Yang Y., Lin M.C., Ching Y.P., Lam S.K., Xia H.H.X., Tu S., Zou B., Wang J., Li G., He H., Gu Q., Peng J., Kung H. and Wong B.C.Y., FHL2 As a Co-Factor of XAF1 in the Induction of Apoptosis, Gastroenterology. 2004, 126 (4 Suppl 2): S938.

Zou B., Lin M.C., Lam S.K., Tu S., Yang Y., Wang J., He H., Peng J., Kung H. and Wong B.C.Y., Hypermethylation Status Around Exon 1 of XIAP-Associated Factor 1 in Human Gastric and Colon Cancer Cell Lines, Gastroenterology. 2004, 126 (4 Suppl 2): T981.

Researcher : Zou L

List of Research Outputs

Cheung R.T.F., Zou L., Cheng P.W. and Lee T.Y., A dynamic computed tomographic study of chronic ischemia in patients with unilateral or bilateral severe stenosis or unilateral moderate stenosis of the internal carotid artery, Cerebrovascular Diseases. 2004, 17(Suppl 5): 55.

Cheung R.T.F. and Zou L., Use of the original, modified, or new intracerebral hemorrhage score to predict mortality and morbidity after intracerebral hemorrhage, Stroke. 2003, 2003: 1717-1722.

Zou L., Tang F. and Cheung R.T.F., Mice overexpressing amyloid precursor protein (APP) and harbouring presenilin-1 (PS1) gene are more susceptible to photothrombotic stroke and post-stroke memory impairment than APP transgenic mice, Society for Neuroscience Annual Meeting. 2003.

Zou L., Tang F. and Cheung R.T.F., Presenilin-1 (PS1) increased susceptibility to photothrombotic stroke and post-stroke memory impairment in transgenic mice overexpressing amyloid precursor protein (APP), 9th Medical Research Conference. 2004.

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