GENOME RESEARCH CENTRE
| Researcher : Song Y |
| Project Title: | Genetic linkage analysis of early onset degenerative disc disease in Southern Chinese |
| Investigator(s): | Song Y, Cheah KSE, Cheung KMC, Leong JCY, Chan D |
| Department: | Biochemistry |
| Source(s) of Funding: | Merit Award for RGC CERG Funded Projects |
| Start Date: | 11/2003 |
| Abstract: |
| To detect linkage associated with early onset familial DDD by performing a genome-wide scan; to define the chromosomal location of the early onset familial DDD gene; to begin preliminary work towards positional/candidate clonning. |
| Project Title: | Genetic linkage analysis of early onset degenerative disc disease in Southern Chinese |
| Investigator(s): | Song Y, Cheah KSE, Cheung KMC, Leong JCY, Chan D |
| Department: | Biochemistry |
| Source(s) of Funding: | Competitive Earmarked Research Grants (CERG) |
| Start Date: | 11/2003 |
| Abstract: |
| To detect linkage associated with early onset familial DDD by performing a genome-wide scan; to define the chromosomal location of the early onset familial DDD gene; to begin preliminary work towards positional/candidate clonning. |
| Project Title: | Genetic study of Alzheimer disease in Chinese |
| Investigator(s): | Song Y, Sham PC, Chu LW |
| Department: | Genome Research Centre |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 01/2005 |
| Abstract: |
| Refer to hard copy |
| Project Title: | Mapping and cloning a new gene on chromosome 8q24 for amyotrophic lateral sclerosis in a large Chinese family |
| Investigator(s): | Song Y, Ho SL, Fong CY, Ramsden D.B. |
| Department: | Biochemistry |
| Source(s) of Funding: | Competitive Earmarked Research Grants (CERG) |
| Start Date: | 01/2005 |
| Abstract: |
| To finely map the candidate region using recombinational and linkage disequilibrium approaches; to identify and prioritize candidate genes in this interval for mutation analysis using bioinformatics tools to assess function, Northern blot to assess expression in the nervous system and microarray/quantitative PCR methods to assess differences in candidate gene expression between affected and normal individuals; Screen pathogenic mutations are found, investigate the frequency of mutations in this gene in individuals with sporadic ALS to determine the risk for ALS attributable to this gene. |
| Project Title: | Mapping and cloning a new gene on chromosome 8q24 for amyotrophic lateral sclerosis in a large Chinese family |
| Investigator(s): | Song Y |
| Department: | Biochemistry |
| Source(s) of Funding: | Merit Award for RGC CERG Funded Projects |
| Start Date: | 01/2005 |
| Abstract: |
| Refer to hard copy |
| Researcher : Tsui LC |
| Project Title: |
To construct a haplotype map (HapMap) of 2% of the human genome |
| Investigator(s): | Tsui LC, Tam PKH, Waye MMY, Wong JTF, Mak WW, Wu MCS, Song Y, Tsui SKW, Xue HH |
| Department: | Genome Research Centre |
| Source(s) of Funding: | University Grants Committee - Other Funding Scheme |
| Start Date: | 12/2003 |
| Abstract: |
| To define and understand the common ancestral patterns of genetic variations among racial, ethnic, or geographic groups by the construction and delineation of the Haplotype Map (HapMap); to define the halotype blocks by determining the single nucleotide changes (Single Nucleotide Polymorphism, SNP) using current, sophisticated, and high-throughput technologies, on samples that are collected and distributed by the internatioal Human Haplotype Map Consortium. |
| Project Title: | To construct a haplotype map (HapMap) of 2% of the human genome |
| Investigator(s): | Tsui LC, Tam PKH, Waye MMY, Wong JTF, Mak WW, Wu MCS, Tsui SKW, Xue HH, Song Y |
| Department: | Genome Research Centre |
| Source(s) of Funding: | Innovation and Technology Support Programme |
| Start Date: | 12/2003 |
| Abstract: |
| To define and understand the common ancestral patterns of genetic variations among racial, ethnic, or geographic groups by the construction and delineation of the Haplotype Map (HapMap); to define the halotype blocks by determining the single nucleotide changes (Single Nucleotide Polymorphism, SNP) using current, sophisticated, and high-throughput technologies, on samples that are collected and distributed by the internatioal Human Haplotype Map Consortium. |
| List of Research Outputs |
| Tsui L.C., Doctor Philosophiae Honoris Causa, Tel Aviv University. 2005. |
| Tsui L.C., Honorary Fellow, Royal College of Physicians, UK. 2005. |
| Researcher : Wang Y |
| Project Title: | The role of posttranslational modifications in regulating the oligomerization and biological functions of adiponectin |
| Investigator(s): | Wang Y, Xu A |
| Department: | Genome Research Centre |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 02/2005 |
| Abstract: |
| Refer to hard copy |
| List of Research Outputs |
| Wang Y., Adiponectin (Keynote Speech), Australasian Paediatric Endocrine Group Annual Scientific Meeting. 2004. |
| Wang Y., Lam K.S.L., Xu J., Gang L., Xu L.Y., Cooper G.J. and Xu A., Adiponectin Inhibits Cell Proliferation by Interacting with Several Growth Factors in an Oligomerization-dependent Manner, The Journal of Biological Chemistry. The American Society for Biochemistry and Molecular Biology, 2005, 280: 18341-18347. |
| Wang Y., An integrated proteomic approach to characterize protein post-translational modifications and protein-protein interactions, The 3rd HONG KONG MEDICAL GENETICS CONFERENCE, The Hong Kong Society of Medical Genetics . 2005. |
| Wang Y., Lu G., Wong W.P.S., Vliegenthart J.F.G., Gerwig G.J., Lam K.S.L., Cooper G.J. and Xu A., Proteomic and Functional Characterizaion of Endogenous Adiponectin Purified from Fetal Bovine Serum, Proteomics. 2004, 4: 3933-3942. |
| Xu A., Chan K.W., Wang Y., Zhang J., Hoo R.L.C., Xu J., Chow W.S. and Lam K.S.L., Angiopoietin-like Protein 4 Decreases Blood Glucose and Improves Glucose Tolerance but Induces Hyperlipidemia and Hepatic Steatosis in Mice, Proceedings of the National Academy of Sciences of the United States of America. 2005, 102: 6086-6091. |
| Xu A., Chan K.W., Hoo R.L.C., Wang Y., Zhang J., Chen B., Cynthia T., Cooper G.J.S. and Lam K.S.L., Testosterone Selectively Reduces the High Molecular Weight Form of Adiponectin by Inhibiting Its Secretion from Adipocytes, The Journal of Biological Chemistry. 2005, 280: 18073-18080. |