Dept of Medicine

DEPARTMENT OF MEDICINE

Researcher : Ambekar CS

List of Research Outputs

Ambekar C.S., Lee J.S.K., Cheung B.M.Y., Chan L.C., Liang R.H.S. and Kumana C.R., Metabolism of Chloramphenicol Succinate, a Competitive Substrate and Inhibitor of Succinate Dehydrogenase: Possible Reason for its Toxicity, Toxicology in Vitro. 2004, 18: 441-7.

Researcher : Au WY

List of Research Outputs

Au W.Y., Lie A.K.W., Kung A.W.C., Liang R.H.S., Hawkins B.R. and Kwong Y.L., Autoimmune thyroid dysfunction after hematopoietic stem cell transplantation, Bone Marrow Transplantation. 2005, 35(4): 383-8.

Au W.Y., Ma S.Y., Chim J.C.S., Choy C., Loong F., Lie A.K.W., Lam C.C.K., Leung A.Y.H., Tse E.W.C., Yau C.C., Liang R.H.S. and Kwong Y.L., Clinicopathologic features and treatment outcome of mature T-cell and natural killer-cell lymphomas diagnosed according to the World Health Organization classification scheme: a single center experience of 10 years, Annals of Oncology. 2005, 16(2): 206-214.

Au W.Y., Hon C., Cheng V.C.C. and Ma E.S.K., Concomitant zoster myelitis and cerebral leukemia relapse after stem cell transplantation, Annals of Hematology. 2004, 84(1): 59-60.

Au W.Y., Cheung W.C. and Tung H.M., Gilbert's syndrome complicating long term parental nutrition, Journal of hepatology.. 2004, 41(1): 168-169.

Au W.Y., Ma E.S.K., Lam V.M.S., Chan L.C., Pang A.W.K. and Kwong Y.L., Glucose 6-phosphate dehydrogenase (G6PD) deficiency in elderly Chinese women heterozygous for G6PD variants, American Journal of Medical Genetics Part A. 2004, 129A(2): 208 - 211.

Au W.Y. and Liu C.L., Growth of giant hepatic hemangioma after triplet pregnancy , Hepatology. 2005, 42(5): 781.

Au W.Y. and Lo J.Y.C., HTLV-1-related lymphoma in Hong Kong Chinese, American Journal of Hematology. 2004, 78(1): 80-81.

Au W.Y., Lie A.K.W. and Cheng V.C.C., Hematopoietic progenitor cell transplantation from a donor with indeterminate human immunodeficiency virus antibody status, Transfusion. 2005, 45(5): 819-820.

Au W.Y. and Lee J.S.K., Imatinib mesylate (STI-571) and porphyria cutanea tarda in a Chinese patient, Haematologica. 2005, 90: ECR18.

Au W.Y., Gascoyne R.D., Klasa R.D., Connors J.M., Gallagher R.P., Le N.D., Loong F., Law C.K. and Liang R.H.S., Incidence and spectrum of non-Hodgkin lymphoma in Chinese migrants to British Columbia, British Journal of Haematology. 2005, 128: 792-196.

Au W.Y., Kwok J.S.Y., Chu K.M. and Ma E.S.K., Life-threatening cryoglobulinemia in HCV negative Southern Chinese and a novel association with structural aortic abnormalities, Annals of Hematology. 2005, 84: 95-98.

Au W.Y., Cheng V.C.C., Wan T.S.K. and Ma E.S.K., Myelodysplasia masquerading as parvovirus-related red cell aplasia with giant pronormoblasts, Annals of Hematology. 2004, 83(10): 670-1.

Au W.Y., Chan C., Pang A., Lie A.K.W., Liang R.H.S., Yuen P.W., Shek T.W.H., Kwong Y.L. and Pang A.W.K., Nonhematologic malignancies after allogeneic hematopoietic stem cell transplantation: incidence and molecular monitoring, Bone Marrow Transplantation. 2004, 34: 981-985.

Au W.Y., Liu C.L., Lo C.M., Fan S.T. and Ma E.S.K., Potential role for platelet apheresis for post-liver transplant thrombocytosis complicating portal vein thrombosis, Journal of Clinical Apheresis. 2004, 19(4): 192-196.

Au W.Y., Mak W., Ho S.L., Leung S.Y. and Kwong Y.L., Reversible paraneoplastic neuropathy associated with T-cell large granular lymphocyte leukemia, Neurology. 2004, 63(3): 588-589.

Au W.Y., Lie A.K.W., Liang R.H.S., Yuen P.W., Shek T.W.H. and Kwong Y.L., Secondary non-hematologic malignancies after allogeneic stem cell transplantation : incidence and molecular monitoring, 10th Congress of the International Society of hematology, Asian Pacific Division, Nagoya, Japan. Nagoya, Japan, 2004, 110.

Au W.Y., Cheung G.T.Y., Yuen W.H., Kumana C.R. and Kwong Y.L., Successful treatment of relapsed acute promyelocytic leukemia in a patient receiving continuous ambulatory peritoneal dialysis with oral arsenic trioxide, Archite Internal Medicine. 2005, 165: 1067-1068.

Au W.Y., Lie A.K.W., Kung A.W.C., Mak W. and Kwong Y.L., Thyrotoxic periodic paralysis after allogeneic haematopoietic stem cell transplantation, British Journal of Haematology. 2005, 129(1): 160.

Au W.Y., Srivastava G., Wong K.Y., Chung L.P., Ma E.S.K., Wan T.S.K. and Kwong Y.L., Transformation of diffuse large B-cell lymphoma into pre-B acute lymphoblastic leukemia: clinicopathologic features and clonal relationship, Human Pathology. 2004, 35(7): 900-903.

Au W.Y., Chim J.C.S., Lie A.K.W., Leung A.Y.H., Tse E.W.C., Ma S.Y., Liang R.H.S., Pang A.W.K., Kumana C.R. and Kwong Y.L., Treatment of relapsed acute promyelocytic leukemia by arsenic-based strategies without hematopoietic stem cell transplantation in Hong Kong: a seven-year experience, American Society of Haematology Annual Scientific Meeting. 2004.

Au W.Y., Lam P. and Shek T.W.H., Uncommon presentations of some common malignancies: Case 2. Nasopharyngeal carcinoma followed by secondary acute promyelocytic leukemia presenting with respiratory distress, Journal of Clinical Oncology. 2005, 23(6): 1314-1315.

Au W.Y., Lie A.K.W. and Cheng V.C.C., VDRL screening and haemopoietic stem cell transplantation, Bone Marrow Transplantation. 2005, 35: 1027-1028.

Au W.Y., Hon C., Chan A.C., Sano T. and Chan H.H.L., Vitiligo as a paraneoplastic syndrome preceding pituitary adenoma and subsequent acute lymphoblastic leukemia, Leukaemia & Lymphoma. 2004, 45(8): 1683-1685.

Chan G.S.W., Lam M.F., Au W.Y., Tse K.C., Chan D.T.M., Lai K.N. and Chan K.W., IgA nephropathy complicating graft-versus-host disease, another nephropathy causing nephrotic syndrome after bone marrow transplantation, Histopathology. 2004, 45(6): 648-651.

Chim J.C.S., Ooi C.G.C., Loong F., Au W.Y., Au W.Y. and Lie A.K.W., Side effects and good effects from new chemotherapeutic agents. Bortezomib in primary refractory plasmacytoma, Journal of Clinical Oncology. 2005, 23(10): 2426-8.

Chiu A., Tam S., Au W.Y., Chan S.C., Liu C.L. and Fan S.T., MARS treatment for a patient presenting with acquired hepatic glutamine synthetase deficiency after orthotopic liver transplantation (Case Report), Liver Transplantation. 2005, 11(3): 353-355.

Hon C., Law R.W., Shek T.W.H. and Au W.Y., CNS Manifestations of Malignancies CASE 1. Conjunctival Relapse of Acute Lymphoblastic Leukemia Heralding Pituitary and CNS Disease , Journal of Clinical Oncology. 2005, 23(18): 4225-4226.

Hon C., Ma E.S.K., Yau K. and Au W.Y., CNS Manifestations of Malignancies CASE 3. Leukemic Optic Neuropathy Complicating Leukemia Cutis , Journal of Clinical Oncology. 2005, 23(18): 4229-4230.

Hon C., Au W.Y. and Liang R.H.S., Conjunctival carcinoma as a novel post-stem cell transplantation malignancy, Bone Marrow Transplantation. 2004, 34(2): 181-182.

Hon C., Ho S.L., Ma E.S.K., Trendell-Smith N.J. and Au W.Y., High-grade lymphoma after azathioprine treatment for Vogt-Kaganayi-Harada syndrome, Leukemia & Lymphoma . 2005, 46: 289-292.

Hon C., Mak W., Kwok A.K.H. and Au W.Y., Immunological and electrophysiological investigations of severe ptosis after bone marrow transplantation, Bone Marrow Transplantation. 2004, 34(5): 455-458.

Hon C., Au W.Y. and Shek T.W.H., Intraocular lymphoma as a masquerade syndrome complicating cerebral lymphoma of the corpus callosum, Annals of Hematology. 2005, 84(3): 203 - 204.

Hon C., Law R.W. and Au W.Y., Scleromalacia perforans complicating graft-versus-host disease, British Journal of Haematology. 2005, 129(1): 1.

Hon C., Ma E.S.K. and Au W.Y., Unusual Sites of Metastatic Malignancy - CASE 3. Acute Leukemia Presenting As Bilateral Proptosis , Journal of Clinical Oncology. 2004, 22(24): 5015-5016.

Hui C.K., Bowden S., Jackson K., Au W.Y., Fong D.Y.T., Lie A.K.W., Chim J.C.S., Liang R.H.S. and Lau G., Clinical significance of intrahepatic hepatitis B virus covalently closed circular DNA in chronic hepatitis B patients who received cytotoxic chemotheraphy, Blood. 2005, 105(6): 2616-2617.

Hui C.K., Lie A.K.W., Au W.Y., Ma S.Y., Leung A.Y.H., Zhang H., Sun J.Z., Cheung W.W.W., Chim J.C.S., Kwong Y.L., Liang R.H.S. and Lau G., Effectiveness of prophylactic Anti-HBV therapy in allogeneic hematopoietic stem cell transplantation with HBsAg positive donors, American Journal of Transplantation. 2005, 5(6): 1437-45.

Hui C.K., Sun J., Au W.Y., Lie A.K.W., Yueng Y.H., Zhang H., Lee N.P., Hou J., Liang R.H.S. and Lau G., Occult hepatitis B virus infection in hematopoietic stem cell donors in a hepatitis B virus endemic area, Journal of Hepatology. 2005, 42(6): 813-9.

Lie A.K.W., Au W.Y., Ma S.Y., Leung A.Y.H., Tse E.W.C., Chan G.C.F., Ha S.Y., Lau Y.L., Kwong Y.L. and Liang R.H.S., Haemopoietic stem cell transplantation in Hong Kong – 14 years of experience at Queen Mary Hospital, 10th Congress of the International Society of hematology, Asian Pacific Division, Nagoya, Japan. Nagoya, Japan, 2004.

Pang A.W.K., Au W.Y. and Kwong Y.L., Caveolin-1 gene is coordinately regulated with the multidrug resistance 1 gene in normal and leukemic bone marrow , Leukemia Research . 2004, 28(9): 973-977.

Solal-Celigny P., Roy P., Colombat P., White J., Armitage J.O., Arranz-Saez R., Au W.Y., Bellei M., Brice P., Caballero D., Coiffier B., Conde-Garcia E., Doyen C., Federico M., Fisher R.I., Garcia-Conde J.F., Guglielmi C., Hagenbeek A., Haioun C., LeBlanc M., Lister A.T., Lopez-Guillermo A., McLaughlin P., Milpied N., Morel P., Mounier N., Proctor S.J., Rohatiner A., Smith P., Soubeyran P., Tilly H., Vitolo U., Zinzani P.L., Zucca E. and Montserrat E., Follicular Lymphoma International Prognostic Index, Blood. 2004, 104(5): 1258-1265.

Srivastava G., Shen L., Au W.Y., Kwong Y.L. and Liang R.H.S., Molecular pathogenesis of nasal NK/T-cell lymphoma, Abstract of the Proc of 63rd Annual Meeting of the Japanese Cancer Association, 29 September - 1 October 2004, Fukuoka, Japan. 2004.

Szeto C.H., Shek T.W.H., Lie A.K.W., Au W.Y., Yuen P.W. and Kwong Y.L., Squamous cell carcinoma of the tongue complicating chronic oral mucosal graft-versus-host disease after allogeneic hematopoietic stem cell transplantation, American Journal of Hematology. 2004, 77(2): 200-202.

Tsang S.K. and Au W.Y., Cough mixture abuse in pregnancy, folate deficiency, and neural tube defects?, American Journal of Hematology. 2005, 78(2): 163.

Yeung C.K., Ma S.Y., Chan H.H.L., Trendell-Smith N.J. and Au W.Y., Primary CD30+ve Cutaneous T-cell Lymphoma Associated with Chronic Burn Injury in a Patient with Longstanding Psoriasis, American Journal of Dermatopathology. 2004, 26(5): 394-396.

Researcher : Chan AKL

List of Research Outputs

Huang F., Ma L., Wu A.Y.Y., Tian L., Chan K.W., Trendell-Smith N.J., Lam A.C., Chan A.K.L., Lo C.K., Chik S.C.C., Ko K.H., To K.W., Kam S.K., Fong L.P., Li X.S., Leung S.Y., Ng M.H., Stott D.I., Liew F.Y. and MacPherson G.G., Systemic autoimmune disease induced by dendritic cells that have captured necrotic but not apoptotic dying cells, Proceedings of the 12th International Congress of Immunology and the 4th Annual Conference of FOCIS, Montreal, Canada, July 18-23, 2004. 2004.

Researcher : Chan ASW

List of Research Outputs

Li V.S.W., Wong C.W., Chan T.L., Chan A.S.W., Zhao W., Chu K.M., Chen X., Yuen S.T., Leung S.Y. and So S., Mutations of PIK3CA in gastric adenocarcinoma, BioMed Central Cancer. 2005, 5: 29.

Researcher : Chan C

List of Research Outputs

Au W.Y., Chan C., Pang A., Lie A.K.W., Liang R.H.S., Yuen P.W., Shek T.W.H., Kwong Y.L. and Pang A.W.K., Nonhematologic malignancies after allogeneic hematopoietic stem cell transplantation: incidence and molecular monitoring, Bone Marrow Transplantation. 2004, 34: 981-985.

Woo J., Lau E..., Lee P., Kwok T..., Lau W.C.S., Chan C., Chiu P.K.Y., Li E..., Sham A.S.K. and Lam D..., Impact of osteoarthritis on quality of life in a Hong Kong Chinese population, Journal of Rheumatology. 2004, 31: 2433-2438.

Researcher : Chan CK

List of Research Outputs

Hui C.K., Lai K.C., Wong R.W.M., Yuen R.M.F., Ng M.M.T., Chan C.K., Hu H.C., Cheung W.W., Lai C.L. and Wong B.C.Y., Outpatients Undergoing Therapeutic Endoscopic Retrograde Cholangiopancreatography: Six-hour Versus Overnight Observation , Journal of Gastroenterology and Hepatology. 2004, 19: 1163-1168.

Wong B.C.Y., Chan O.O., Wong K.W., Ching C.K., Wong R.W.M., Tam S., Lai K.C., Chan C.K., Yuen R.M.F. and Lam S.K., A pilot study of participation in faecal occult blood testing and screening colonoscopy after health education in Hong Kong, European Journal of Cancer Preview. 2005, 14(2): 181-184.

Wong R.W.M., Huang J., Xia H.H.X., Fung F.M.Y., Tong S.M., Cheung K.L., Ho Y.K., Lai K.C., Chan C.K., Chan O.O., Hui C.K., Lam S.K. and Wong B.C.Y., Low-dose rabeprazole, amoxicillin and metronidazole triple therapy for the treatment of Helicobacter pylori infection in Chinese patients , Journal of Gastroenterology and Hepatology. 2005, 20(6): 935-940.

Wong R.W.M., Xiao S.D., HU P.J., Wang W., Gu Q., Huang J., Xia H.H.X., WU S.M., LI C.J., CHEN M.H., CUI Y., Lai K.C., Hu H.C., Chan C.K., Lam S.K. and Wong B.C.Y., Standard treatment for Helicobacter pylori infection is suboptimal in non-ulcer dyspepsia compared to duodenal ulcer in Chinese, Alimentary Pharmacology and Therapeutics. 2005, 21: 73-81.

Wong W.M., Lai K.C., Lam K.F., Hui W.M., Huang J.Q., Xia H.H.X., Hu H.C., Lam C.L.K., Chan C.K., Lam S.K. and Wong B.C.Y., Onset and disappearance of Reflux Symptoms in a Chinese population: a one-year follow-up study, Alimentary Pharmacology and Therapeutics. 2004, 20: 803-812.

Researcher : Chan DTM

Project Title:	Internalization of human anti-DNA antibodies by mesangial cells - the role of [alpha]-actinin and actin
Investigator(s):	Chan DTM, Yung SSY
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002
Completion Date:	10/2004

Abstract:

To examine the role of [alpha]-actinin and actin in the binding and internalization of anti-DNA antibodies by HMC; to investigate the synthesis of [alpha]-actinin and actin in HMC after this process; to determine the effect of anti-DNA antibody internalization on HMC morphology, proliferation, and viability, and its synthesis and secretion of IL-1[beta], IL-6 and TNF-[alpha].

Project Title:	Internalization of anti-DNA antibodies from patients with lupus nephritis by human mesangial cells
Investigator(s):	Chan DTM, Yung SSY
Department:	Medicine
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	11/2003

Abstract:

To characterize HMC membrane and intracellular molecules responsible for binding to anti-DNA antibodies-by trypsin, papain, or pepsin digestion, Western blotting, and protein sequencing; to examine the relationship between the properties of human anti-dsDNA antibodies (isoelectric point, binding to HMC, cellular internalization), their correlation with clinical disease activity, and their effects on cell function, morphology, proliferation, and apoptosis; to elucidate the mechanisms by which anti-dsDNA antibodies bind and penetrate plasma membrane, traverse the cytoplasm, and enter the nucleus of HMC. This will be achieved by kinetic studies using timed flow cytometry, immunohistochemistry, and confocal microscopy. The latter will also be used to investigate the binding between anti-dsDNA antibodies and cytoskeletal structures including myosin. The effects of anti-dsDNA antibodies in the presence or absence of DNA and histones on the synthesis of cytoskeletal molecules will be examined by radiolabelling and immunoprecipitation.

Project Title:	Internalization of anti-DNA antibodies from patients with lupus nephritis by human mesangial cells
Investigator(s):	Chan DTM, Yung SSY
Department:	Medicine
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	11/2003

Abstract:

Project Title:	Modulation of human mesangial cell F-actin and focal adhesion plaque synthesis in diabetic nephropathy
Investigator(s):	Chan DTM, Yung SSY
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Abstract:

To examine the effect of physiological (5mM) and elevated (10mM and 30mM) D-glucose concentrations on cultured human mesangial cells (HMC) viability, proliferation, and activation - the latter will be determined by [alpha]-smooth muscle actin staining; to determine how physiological and elevated glucose concentrations modulate F-actin, [alpha]-actinin, vinculin and PKC expression; to determine the morphological changes of HMC cytoskeletal components by scanning and transmission electron microscopy.

Project Title:	The effect of anti-DNA antibodies on the synthesis of pro-fibrotic cytokines, growth factors and matrix proteins in proximal tubular epithelial cells during lupus nephritis
Investigator(s):	Chan DTM, Yung SSY
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Abstract:

To isolate paired polyclonal anti-DNA antibodies from 12 patients with a history of clinically severe lupus nephritis during disease flare and remission; to determine the effect of human polyclonal anti-DNA antibodies on PTEC viability, proliferation and activation; to determine the effect of anti-DNA antibodies on PTEC secretion of cytokines; to investigate how anti-DNA-mediated alterations of cytokines and growth factors modulate changes in matrix synthesis and deposition.

Project Title:	Effects of mycophenolate mofetil and cyclophosphamide on mesangial cell proliferation and function in MRL/1pr mice with lupus nephritis
Investigator(s):	Chan DTM, Yung SSY
Department:	Medicine
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	12/2004

Abstract:

To assess the clinical effects of mycophenolate mofetil (MMF) and cyclophosphamide on disease manifestations in MRL/1pr mice with lupus nephritis; to determine the effects of MMF and cyclophosphamide on serum levels of anti-DNA antibodies, pro-inflammatory mediators, and markers of fibrosis; to examine the effects of MMF and cyclophosphamide on kidney histopathology in MRL/1pr mice with lupus nephritis, focusing on mesangial cell proliferation, synthesis of inflammatory/fibrosis mediators, and production of matrix components. The data will be analyzed in relation to corresponding changes in the parameters indicating disease activity, inflammatory cell infiltration, and immune complex deposition; to isolate mesangial cells from treated and control mice, and to assess in vitro mesangial cell activation and synthesis of inflammatory/fibrosis mediators and matrix components; to investigate whether the actions of MMF or cyclophosphamide on mesangial cells are mediated via the protein kinase C (PKC) pathway.

Project Title:	Effects of mycophenolate mofetil and cyclophosphamide on mesangial cell proliferation and function in MRL/1pr mice with lupus nephritis
Investigator(s):	Chan DTM
Department:	Medicine
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

Refer to hard copy

List of Research Outputs

Chan D.T.M., Chapman J., Lee C.J., Morad Z., Ona E.T., Park K., Pingle A., Rizvi S.A., Shaheen F.A., Sumethkull V., Tang X.D. and Watarai Y., A survey on the prevalence and management of hepatitis B after renal transplantation in Asian-Pacific countries, Transplantation Proceedings. 2004, 36(7): 2126-2127.

Chan D.T.M., Antiviral therapy for hepatitis B after kidney transplantation, Transplantation Proceedings. 2004, 36(7): 2124-2125.

Chan D.T.M., Hepatitis B and Dialysis, In: Burton D Rose, UpToDate - Physician information resource available on-line and on CD-ROM. Waltham, MA 02453, U.S.A., UpToDate, 2004.

Chan D.T.M., Hepatitis C and kidney transplantation, Asian Pacific Association for the Study of Liver Diseases Scientific Meeting, 11-15 December 2004, New Delhi, India. 2004.

Chan D.T.M., Tsang R.C.W., Tsang W.S. and Yung S.S.Y., Induction of Proximal Tubular Epithelial Cell Interleukin-6 Synthesis by Anti-DNA Antibodies Varies with the Activity of Lupus Nephritis, Journal of the American Society of Nephrology. 2004, 15: 684A.

Chan D.T.M., Kidney Transplantation in Hong Kong – Recent Developments , 9th Hong Kong Medical Forum. 2004.

Chan D.T.M. and Chan M.K., Lipid disorders in renal failure, In: Nissenson AR , Fine RN, and Gentile GE, Clinical Dialysis. Conn., USA, Appleton & Lange, 2004, 4th edition.

Chan D.T.M., Lipoprotein metabolism in dialysis patients, In: Nissenson, Allen R; Fine, Richard N. , Clinical Dialysis. New York, U.S.A., McGraw-Hill Publ, 2005, Chapter 28.

Chan D.T.M., Tse K.C., Tang C.S.O., Lai K.N. and Li F.K., Long-term outcome of patients with diffuse proliferative lupus nephritis treated with prednisolone and oral cyclophosphamide followed by azathioprine. , Lupus. 2005, 14(4): 265-272.

Chan D.T.M., Tse K.C., Tang C.S.O., Mok T.M.Y., Li F.K. and Hong Kong Nephrology Study G.R.O.U.P., Long-term study of mycophenolate mofetil as continuous induction and maintenance treatment for diffuse proliferative lupus nephritis, Journal of American Society of Nephrology. 2005, 16(4): 1076-1084.

Chan D.T.M., Lupus Nephritis, MetroDaily, 27 August. Hong Kong, 2004, 22.

Chan D.T.M., Lupus nephritis: induction therapy. , Lupus. 2005, 14 Suppl 1: S27-S32.

Chan D.T.M., Preventing renal failure in patients with severe lupus nephritis, Kidney International. 2005, 67 (Suppl 94): S116-S119.

Chan D.T.M., Prevention of renal failure in lupus nephritis, International Society of Nephrology Conference on Prevention of Renal Disease Progression, June 29 to July 1, 2004, Hong Kong. 2004.

Chan D.T.M., Tse K.C., Tang C.S.O., Lai K.N. and Ho S.K.N., Prospective study on lamivudine-resistant hepatitis B in renal allograft recipients, American Journal of Transplantation. 2004, 4(7): 1103-1109.

Chan D.T.M., Systemic Lupus Erythematosus, Sing Pao, 1 September. Hong Kong, 2004, E07.

Chan D.T.M., Treatment of Severe Lupus Nephritis, World Congress of Nephrology, 24-28 June 2005, Singapore. 2005.

Chan G.S.W., Lam M.F., Au W.Y., Tse K.C., Chan D.T.M., Lai K.N. and Chan K.W., IgA nephropathy complicating graft-versus-host disease, another nephropathy causing nephrotic syndrome after bone marrow transplantation, Histopathology. 2004, 45(6): 648-651.

Lai K.N., Leung J.C.K., Chan L.Y., Li F.K., Tang S.C.W., Lam M.F., Tse K.C., Yip T., Chan D.T.M., Wieslander A. and Vlassara H., Differential expression of receptors for advanced glycation end-products in peritoneal mesothelial cells exposed to glucose degradation products, Clinical and Experimental Immunology. 2004, 138: 466-475.

Lam M.F., Yip P.S., Leung J.C.K., Chan D.T.M., Lo W.K. and Lai K.N., Mannose binding lectin gene mutation and incidence rate of peritonitis in long-term peritoneal dialysis patients, Journal of American Society of Nephrology. 2004, 15: 598A.

Lam M.F., Lo W.K., Chu F.S., Li F.K., Yip T.P., Tse K.C., Chan D.T.M. and Lai K.N., Retroperitoneal leakage as a cause of ultrafiltration failure, Peritoneal Dialysis International. 2004, 24(5): 466-470.

Lam M.F., Yip T.P.S., Tse K.C., Li F.K., Lui S.L., Lai K.N. and Chan D.T.M., Sirolimus in kidney transplantation: a pilot study in Chinese patients, Hong Kong Journal of Nephrology. Hong Kong, 2004, 6(1): 38-42.

Leung J.C.K., Chan L.Y., Tsang W.L., Guo H., Tang S.C.W., Chan D.T.M. and Lai K.N., Differential expression of aquaporins in the kidneys of streptozotocin-induced diabetic mice , Nephrology. 2005, 10: 63-72.

Leung J.C.K., Chan Y.Y., Li F.K., Tang S.C.W., Chan K.W., Chan D.T.M., Lam M.F., Wieslander A. and Lai K.N., Glucose degradation products downregulate ZO-1 expression in human peritoneal mesothelial cells: the role of VEGF, Nephrology Dialysis Transplantation. 2005, 20(7): 1336-1349.

Li F.K., Lam M.F., Yip P.S., Chan D.T.M. and Lai K.N., Refractory fluid overload in CAPD patients: management strategies and outcomes, Journal of American Society of Nephrology. 2004, 15: 637A.

Lo W.K., Lui S.L., Chan D.T.M., Li F.K., Lam M.F., Tse K.C., Tang C.S.O., Choy C.B.Y. and Lai K.N., Minimal and optimal peritoneal Kt/V targets: results of an anuric peritoneal dialysis patient's survival analysis. , Kidney International. 2005, 67(5): 2032-2038.

Lui S.L., Chan D.T.M. and Lai K.N., Au update on immunosuppressive drugs for renal transplantation, Medical Progress. Hong Kong, 2005, 32(2): 57-63.

Lui S.L., Wong R.W.M., Ng S.Y., Chan D.T.M., Lai K.N. and Lo W.K., Seroprevalence of Helicobacter pylori in Chinese patients on continuous ambulatory peritoneal dialysis , Nephrology. 2005, 10(1): 21-24.

Lui S.L., Tang S., Li F.K., Choy C.B.Y., Chan D.T.M., Lo W.K. and Lai K.N., Tuberculous infection in southern Chinese renal transplant recipients, Clinical transplantation. 2004, 18(6): 666-671.

Mok T.M.Y., Leung P.Y., Lao T.T.H., Lo Y., Chan D.T.M., Wong R.W.S. and Lau W.C.S., Clinical predictors of fetal and maternal outcome in Chinese patients with systemic lupus erythematosus, 11th APLAR Bi-annual Congress, Jeju, Korea 11-16 September 2004.

Mok T.M.Y., Leung P.Y., Lao T.T.H., Lo Y., Chan D.T.M., Wong W.S. and Lau W.C.S., Clinical predictors of fetal and maternal outcome in Chinese patients with systemic lupus erythematosus, Annals Of The Rheumatic Diseases. 2004, 63: 1705-1706.

Mok T.M.Y., Lo Y., Chan D.T.M., Wong R.W.S. and Lau W.C.S., Tuberculosis in systemic lupus erythematosus in an endemic area and the role of isoniazid prophylaxis during corticosteroid therapy. , Journal of rheumatology. 2005, 32(4): 609-615.

Tang S.C.W., Ho Y.W., Leung V.K., Leung C.Y., Chan D.T.M. and Lai K.N., Lamivudine improves renal outcome in hepatitis-B related membranous nephropathy, Journal of American Society of Nephrology. 2004, 15: 341A.

Tang S.C.W., Leung W.S., Chan V., Chu C.M., Lam B., Leung H., Lam W.O., Ho Y.W., Chan D.T.M. and Lai K.N., Sleep apnea in patients undergoing nocturnal peritoneal dialysis., Peritoneal Dialysis International. 2004, 24 (S2): S49.

Yung S.S.Y., Tsang R.C.W., Leung J.K.H. and Chan D.T.M., Anti-DNA antibodies from patients with lupus nephritis induce IL-6 expression in renal tubular epithelial cells, Nephrology. 2005, 10: A277.

Yung S.S.Y., Liu Z.H., Li L.S. and Chan D.T.M., Emodin abrogates mediators of inflammation and fibrosis and morphological changes in human peritoneal mesothelial cells induced by peritoneal dialysis fluid, Nephrology. 2005, 2005: A64.

Yung S.S.Y., Tsang R.C.W., Leung J.K.H. and Chan D.T.M., Induction of IL-6 by anti-DNA antibodies in proximal tubular epithelial cells varies with the activity of lupus nephritis, Lupus. 2005, 14: 237.

Yung S.S.Y., Tsang R.C.W., Leung J.K.H. and Chan D.T.M., Induction of IL-6 synthesis in proximal tubular epithelial cells by anti-DNA antibodies varies with lupus nephritis activity, 10th Medical Research Conference. 19-20 February 2005. Nephrology 45.

Zhang Q., Yung S.S.Y., Leung J.K.H. and Chan D.T.M., High Glucose Concentration Reduces Human Mesangial Cell alpha-actinin-1 and F-actin Expression through the induction of TGF-beta1 and PKC-alpha, Journal of the American Society of Nephrology. 2004, 15: 726A.

Zhang Q., Yung S.S.Y., Leung J.K.H. and Chan D.T.M., The effect of elevated glucose concentration on the expression of alpha-actinin-1 and F-actin in human mesangial cells, 10th Medical Research Conference. 19-20 February 2005. Nephrology 47.

Researcher : Chan HHL

Project Title:	The role of epidermal cooling in improving the outcome of laser therapy in the treatment of Nevus of Ota
Investigator(s):	Chan HHL, Lam LK
Department:	Medicine
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	12/2000

Abstract:

To assess whether epidermal cooling would reduce pain, swelling, complications but improve clinical response and reduce the number of session required for laser treatment for Nevus of Ota.

Project Title:	The use of vascular lasers in the treatment of port wine stain in chinese
Investigator(s):	Chan HHL, Wei WI
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	11/2001

Abstract:

To establish the importance of epidermal cooling when 585nm pulse dye laser is used for the treatment of port wine stain in Chinese; to compare the clinical efficacy, patients' tolerability and complications of two commerical available vascular lasers that are equipped with different cooling devices in the treatment of port wine stain in Chinese.

List of Research Outputs

Au W.Y., Hon C., Chan A.C., Sano T. and Chan H.H.L., Vitiligo as a paraneoplastic syndrome preceding pituitary adenoma and subsequent acute lymphoblastic leukemia, Leukaemia & Lymphoma. 2004, 45(8): 1683-1685.

Chan H.H.L. and Kono T., The Use Of Lasers And Intense Pulsed Light Sources For The Treatment Of Pigmentary Lesions, Skin Therapy Letter. 2004, 9(8): 5-7.

Chan H.H.L., Wong S.Y., Ho W.S., Lam L.K. and Wei W.I., The use of pulsed dye laser for the prevention and treatment of hypertrophic scars in Chinese persons, Dermatologic Surgery. 2004, 30: 987-994.

Chuh A.A.T. and Chan H.H.L., Effect On Quality Of Life In Patients With Pityriasis Rosea: Is It Associated With Rash Severity?, International Journal Of Dermatology. 2005, 44(5): 372-7.

Chuh A.A.T., Chan H.H.L. and Zawar V., Is Human Herpesvirus 7 The Causative Agent Of Pityriasis Rosea?--a Critical Review, International Journal Of Dermatology. 2004, 43(12): 870-5.

Yeung C.K., Ma S.Y., Chan H.H.L., Trendell-Smith N.J. and Au W.Y., Primary CD30+ve Cutaneous T-cell Lymphoma Associated with Chronic Burn Injury in a Patient with Longstanding Psoriasis, American Journal of Dermatopathology. 2004, 26(5): 394-396.

Researcher : Chan JCK

Project Title:	Application of the APACHE II and III prognostic scoring methods in the 14-bed Intensive Care Unit at Queen Mary Hospital
Investigator(s):	Chan JCK, Lam WK
Department:	Medicine
Source(s) of Funding:	Health Services Research Fund - Full Grants
Start Date:	07/1995

Abstract:

To evaluate the usefulness of the APACHE II and III prognostic scoring methods in the 14-bed ICU at Queen Mary Hospital; to compare our ICU performance in terms of actual mortality with the predicted mortality based on the APACHE II predictive equation; to correlate the APACHE II and III severity scores. As the mortality prediction equation for APACHE III is only commercially available, a close correlation between APACHE II and III scores would support using the APACHE II scoring and prediction method as the standard method rather than financially investing in the APACHE III system.

List of Research Outputs

Researcher : Chan K

List of Research Outputs

Chan K. and Chan V.N.Y., Microarray and diagnosis of thalassemia and haemophilia B, Xth Congress of the International Society of Hematology, Asian Pacific Division, Nagoya, Japan. 2004.

Researcher : Chan KW

List of Research Outputs

Chan K.W., Xu A., Hoo R.L.C., Tan K.C.B., Zhang J., Lam C.W. and Lam K.S.L., Selective Reduction of the High Molecular Weight Form of Adiponectin by Testosterone: A Potential Mechanism That Underlies the Sexual Dimorphism of Adiponectin Oligomeric Distribution, The Endocrine Society’s 87th Annual Meeting, June 4-7, 2005, San Diego, USA. 2005.

Chan K.W., Xu A., Hoo R.L.C., Lam C.W. and Lam K.S.L., Sexual dimorphism of adiponectin: Why do men have higher risk to diabetes and atherosclerosis than women?, 10th Medical Research Conference, The University of Hong Kong. 19-20 Feb 2005. Endocrinology 24.

Xu A., Chan K.W., Wang Y., Zhang J., Hoo R.L.C., Xu J., Chow W.S. and Lam K.S.L., Angiopoietin-like Protein 4 Decreases Blood Glucose and Improves Glucose Tolerance but Induces Hyperlipidemia and Hepatic Steatosis in Mice, Proceedings of the National Academy of Sciences of the United States of America. 2005, 102: 6086-6091.

Xu A., Lam M.C., Chan K.W., Wang Y., Zhang J.C.L., Xu J., Chen B., Chow W.S., Tso A.W. and Lam K.S.L., Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice, Proc Natl Academic Science USA. 2005, 102(17): 6086-91.

Xu A., Lam C.W., Chan K.W., Zhang J., Hoo R.L.C., Xu J., Chen B. and Lam K.S.L., Angiopoietin-like protein 4 is a novel metabolic hormone with therapeutic potentials for hyperglycemia and insulin resistance, 10th Medical Research Conference, The University of Hong Kong. 19-20 Feb 2005. Endocrinology 22.

Xu A., Chan K.W., Hoo R.L.C., Wang Y., Zhang J., Chen B., Cynthia T., Cooper G.J.S. and Lam K.S.L., Testosterone Selectively Reduces the High Molecular Weight Form of Adiponectin by Inhibiting Its Secretion from Adipocytes, The Journal of Biological Chemistry. 2005, 280: 18073-18080.

Xu A., Chan K.W., Hoo R.L.C., Wang Y., Tan K.C.B., Zhang J.C.L., Chen B., Lam M.C., Tse C., Cooper G.J. and Lam K.S.L., Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes, J Biol Chem. 2005, 280(18): 18073-80.

Researcher : Chan KW

List of Research Outputs

Researcher : Chan LY

List of Research Outputs

Chan L.Y., Leung J.C.K., Tsang W.L., Tang S.C.W. and Lai K.N., Activation of tubular epithelial cells by mesangial-derived TNF-alpha: glomerulotubular communication in IgA nephropathy , Kidney International. 2005, 67: 602-612.

Chan L.Y., Leung J.C.K. and Lai K.N., Novel mechanisms of tubulointerstitial injury in IgA nephropathy: a new therapeutic paradigm in the prevention of progressive renal failure, Clinical and Experimental Nephrology . 2004, 8: 297-303.

Lai K.N., Leung J.C.K., Chan L.Y., Li F.K., Tang S.C.W., Lam M.F., Tse K.C., Yip T., Chan D.T.M., Wieslander A. and Vlassara H., Differential expression of receptors for advanced glycation end-products in peritoneal mesothelial cells exposed to glucose degradation products, Clinical and Experimental Immunology. 2004, 138: 466-475.

Lai K.N., Chan L.Y., Tsang W.L., Tang S.C.W. and Leung J.C.K., Differential regulation of AT1 and AT2 receptors by angiotensin II in human mesangial and renal proximal tubular epithelial cells, Journal of American Society of Nephrology. 2004, 15: 841A.

Lai K.N., Chan L.Y. and Leung J.C.K., Mechanisms of tubulointerstitial injury in IgA nephropathy, Kidney International. 2005, 67(suppl 94): S110-S115.

Lai K.N., Chan L.Y., Tang S.C.W., Tsang W.L., Li F.K., Lam M.F., Lui S.L. and Leung J.C.K., Mesangial expression of angiotensin II receptor in IgA nephropathy and its regulation by polymeric IgA1 , Kidney International. 2004, 66: 1403-1416.

Lai K.N., Tang S.C.W., Tsang W.L., Chan L.Y. and Leung J.C.K., Ganaderma extract prevents albumin-induced oxidative damage and chemokine synthesis in cultured human proximal tubular epithelial cells, Journal of American Society of Nephrology. 2004, 15: 107A.

Leung J.C.K., Chan L.Y., Tsang W.L., Tang S.C.W. and Lai K.N., Anti-macrophage migration inhibitory factor reduces transforming growth factor-beta 1 expression in experimental IgA nephropathy, Nephrology Dialysis Transplantation. 2004, 19: 1976-1985.

Leung J.C.K., Chan L.Y., Tsang W.L., Guo H., Tang S.C.W., Chan D.T.M. and Lai K.N., Differential expression of aquaporins in the kidneys of streptozotocin-induced diabetic mice , Nephrology. 2005, 10: 63-72.

Leung J.C.K., Chan L.Y., Tsang W.L., Tang S.C.W. and Lai K.N., Increased synthesis of TNF-a and IL-6 by mesangial cells cultured with polymeric anionic IgA from patients with IgA nephropathy, Journal of American Society of Nephrology. 2004, 15: 224A.

Tang S.C.W., Leung J.C.K., Chan L.Y., Tsang W.L. and Lai K.N., Albumin-induced interleukin-8 expression in renal tubular cells is abrogated by angiotensin type 2 but not type 1 receptor blockade, Journal of American Society of Nephrology. 2004, 15: 847A.

Researcher : Chan MMW

Project Title:	Candidate gene polymorphisms associated with asthma and allergy in Hong Kong
Investigator(s):	Chan MMW, Ip MSM, Tan-Un KC
Department:	Medicine
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2001
Completion Date:	08/2004

Abstract:

To recruit 150 Chinese patients with asthmas from the Asthma Clinic at the Queen Mary Hospital in Hong Kong; to phenotype these patients according to their asthma severity and atopic status; to determine the prevalence of some of the specific polymorphisms of genes associated with allergy and asthma; to recruit an equal number of controls without asthma and to determine the prevalence of specific polymorphisms of genes associated with allergy and asthma.

Project Title:	A surveillance program of tuberculosis in old age homes in Hong Kong
Investigator(s):	Chan MMW, Chu LW, Lam WK, Wong C.P., Kam K.M., Dai D.L.K.
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	11/2001

Abstract:

To conduct a cross-sectional screening examination for tuberculosis in old age homes in several districts in Hong Kong, SAR; to ensure that directly observed therapy (DOT) is given to those with active disease diagnosed through the screening program in collaboration with the Hong Kong Government Tuberculosis and Chest Service (Chest Service); to provide a screening examination for tuberculosis for new residents on entry to the old age homes participating in the program; to participate, in collaboration with the Chest Service, in contact examination on residents in the same home from which an active case of tuberculosis is being diagnosed; to provide education to the staff of old age homes on early recognition of tuberculosis, its treatment and possible side effects to evaluate the effectiveness of the program.

Project Title:	A surveillance program of tuberculosis in old age homes in Hong Kong
Investigator(s):	Chan MMW, Chu LW, Lam WK, Dai D.L.K., Wong C.P., Kam K.M.
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	01/2004

Abstract:

To conduct a cross-sectional screening examination for tuberculosis in old age homes in several districts in Hong Kong, SAR; to ensure that directly observed therapy (DOT) is given to those with active disease diagnosed through the screening program in collaboration with the Hong Kong Tuberculosis and Chest Service, Department of Health (Chest Service); to provide a screening examination for tuberculosis for new residents on entry to the old age homes participating in the program; to participate, in collaboration with the Chest Service, in contact examination on residents in the same home from which an active case of tuberculosis is being diagnosed; to provide education to the staff of old age homes on early recognition of tuberculosis, its treatment and possible side effects; to evaluate the effectiveness of the program.

List of Research Outputs

Bovornkitti S., Lam W.K. and Chan M.M.W., Smoking and lung health. In Ed. Ip MSM, Chan MMW, Lam WK, Zhong NS, Respiratory Medicine : An Asian Perspective. Hong Kong University Press, Hong Kong, 2005, Chapter 20: 347-363.

Brauer M. and Chan M.M.W., Air pollution and Health, In: Ip SM, Chan MMW, Zhong NS, Lam WK, Respiratory Disease - The Asian Perspective. The University of Hong Kong Press, 2005, 327-346.

Chan M.M.W. and Wong G.K., Asthma Epidemiology, In: Ip SM, ChanMMW, Zhong NS, Lam WK, Respiratory Disease- The Asian Perspective. The University of Hong Kong Press, 2005, 3-24.

Chan M.M.W. and Ip M.S.M., Asthma Management, In: Ip SM, Chan MMW, Zhong NS, Lam WK, In: Respiratory Disease- The Asian Perspective. The University Hong Kong Press, 2005, 25-42.

Chan M.M.W. and Ip M.S.M., Asthma management. In: Ed. Ip MSM, Chan MMW, Lam WK, Zhong NS, Respiratory Medicine - An Asian Perspective. Hong Kong University Press, 2005, pp. 25-42.

Chan M.M.W., Diet, Lifestyle and Health, Impact of demographic change 2005. www.civic-exchange.org. 2005.

Chan M.M.W., Tan-Un K.C., Ip M.S.M., Tsang K.W.T., Ho S.P., Ho J.C.M., Chan H. and Lam W.K., Lung Cancer Susceptibility and Polymorphism of Glutathione-S-transferase Genes in Hong Kong, Lung Cancer. 2004, 45(2): 155-160.

Chan M.M.W. and Ng T.P., Occupational airway disease, In: Ip SM, Chan MMW, Zhong NS, Lam WK, Respiratory Disease - The Asian Perspective . The University of Hong Kong Press, 2005, 365-378.

Chan M.M.W. and Ng T.P., Occupational parenchymal disease, In: Ip SM, Chan MMW, Zhong NS, Lam WK, Respiratory Disease - The Asian Perspective. The University of Hong Kong Press, 2005, 379-400.

Chan M.M.W., Lam W.K., Mak J.C.W., Ho S.P., Chan H.W., Tsang K.W.T., Ip M.S.M., Ho J.C.M., Wong M.P. and Tan-Un K., Polymorphisms of CYP and GST genes, passive smoke and lung cancer risk in Hong Kong Chinese, European Respiratory Journal. 2004, 24: Suppl 48: 457s.

Chan M.M.W., Severe acute respiratory syndrome (SARS) and healthcare workers , Int J Occup Environ Health. 2004, 10(4): 421-7.

Chan M.M.W., Ferguson A., Dimich-Ward H., Watson W., Rousseau R., Lilley M., DyBuncio A. and Becker A., The Canadian Primary Prevention of Asthma in Childhood- outcomes at 7 years, Journal of Allergy and Clinical Immunology. 2005, 116: 49-55.

Chan M.M.W., The Medical Challenge, In: Edited by Loh C, The epi-centre- Severe Acute Respiratory Syndrome . The University of Hong Kong Press, 2004, 17-32.

Chan M.M.W. and Loh C., The coronavirus, In: Edited by Loh C, The epicentre: Severe acute respiratory syndrome. The University of Hong Kong Press, 2004, 43-54.

Dimich-Ward H., Lawson J., Hingston A. and Chan M.M.W., Impact of smoking policy on the respiratory health of food and beverage servers, Scan J Work Environ Health. 2005, 31(1): 75-81.

Dimich-Ward H., Hingstons A., Lawson J. and Chan M.M.W., Impact of workplace policy on the respiratory health of hospitality workers., Chest. 2004, 126: 1048-53.

Dimich-Ward H., Wymer M.L. and Chan M.M.W., Respiratory health survey of respiratory therapists, Chest. 2004, 126(4): 1048-53.

Ho J.C.M., Lam W.K., Wong M.P., Wong M.K., Ooi C.G.C., Ip M.S.M., Chan M.M.W. and Tsang K.W.T., Lymphoepithelioma-like carcinoma of the lung : experience with ten cases, International Journal of Tuberculosis and Lung Disease. 2004, 8(7): 890-895.

Ho J.C.M., Mak J.C.W., Ho S.P., Ip M.S.M., Tsang K.W.T., Lam W.K. and Chan M.M.W., Manganese superoxide dismutase and catalase genetic polymorphisms activity levels and lung cancer risk in Chinese in Hong Kong, 10th Medical Research Conference, Department of Medicine, The University of Hong Kong, February 2005. Abstract Book: RM 66.

Ho J.C.M., Ho S.P., Chan M.M.W., Mak J.C.W., Ip M.S.M., Ko K.W., Yan C.P.K., Wong M.P., Tsang K.W.T. and Lam W.K., Non-small cell lung cancer in Chinese is associated with disturbance in systemic antioxidant profiles, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December, 2004. Respirology. 2004, 9 (Supp): A114.

Ho J.C.M., Wu A.Y.Y., Lam B., Ooi C.G.C., Khong P.L., Ho P.L., Chan M.M.W., Zhong N.S., Ko K.W., Lam W.K. and Tsang K.W.T., Pentaglobin in steroid-resistant severe acute respiratory syndrome, International Journal of Tuberculosis and Lung Disease. 2004, 8(10): 1173-1179.

Ho S.P., Chan M.M.W., Chow K.M., Ip M.S.M. and Mak J.C.W., Antioxidant enzyme activities in healthy Chinese adults: influence of age, gender, and smoking, Respirology. 2005, 10: 305-309.

Ho S.P., Chan M.M.W., Wong M.P., Tsang K.W.T., Ip M.S.M., Lam W.K. and Mak J.C.W., Transforming growth factor (TGF)-beta 1 gene common polymorphisms and plasma TGF-beta 1 levels in patients with lung cancer, 10th Medical Research Conference, Department of Medicine, The University of Hong Kong, February 2005. Abstract Book: RM 60.

Ho S.P., Chan M.M.W., Tsang K.W.T., Ip M.S.M., Lam W.K. and Mak J.C.W., Transforming growth factor (TGF)-beta 1 gene common polymorphisms and plasma TGF-beta 1 levels in patients with lung cancer, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A120.

Ip M.S.M., Ko K.W., Lau A.C.W., Yu W.C., Tang K.S., Choo K., Ling S.O., Chan J.W. and Chan M.M.W., Reference values of spirometry for adult Chinese in Hong Kong, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A162.

Ip M.S.M., Chan M.M.W., Lam W.K. and Zhong N.S., Respiratory Medicine - An Asian Perspective. Hong Kong University Press, 2005.

Lam W.K., Tsang K.W.T., Ooi C.G.C., Ip M.S.M. and Chan M.M.W., Infections: Severe Acute Respiratory Syndrome., In: Ip M, Chan-Yeung M, Lam WK, Zhong NS, Respiratory Medicine, An Asian Perspective. Hong Kong, Hong Kong University Press, 2004, 307-323.

Lam W.K., White N.W. and Chan M.M.W., Lung cancer epidemiology and risk factors in Asia and Africa, International Journal of Tuberculosis and Lung Disease . 2004, 8: 1045-1057.

Lam W.K., Tsang K.W.T., Ooi C.G.C., Ip M.S.M. and Chan M.M.W., Severe Acute Respiratory Syndrome. In: Ed. Ip MSM, Chan MMW, Lam WK, Zhong NS, Respiratory Medicine - An Asian Perspective. Hong Kong University Press, 2005, Chapter 18: pp. 307-323.

Mak J.C.W., Leung C.M., Ho S.P., Law K.W., Tsang K.W.T., Lam W.K., Ip M.S.M. and Chan M.M.W., Genetic susceptibility of transforming growth factor beta-1 common polymorphisms to Chinese patients with asthma, American Thoracic Society International Conference, San Diego, USA. May 2005. Proceedings of the American Thoracic Society. 2005, p.A78.

Mak J.C.W., Ho J.C.M., Ho S.P., Yu W.C., Yew W.W., Tsang K.W.T., Lam W.K., Ip M.S.M. and Chan M.M.W., Increased oxidative stress and altered antioxidant status in Chinese patients with COPD, European Respiratory Journal. 2004, 24: Suppl 48: 62s.

Mak J.C.W., Ho J.C.M., Ho S.P., Leung C.M., Law K.W., Ip M.S.M. and Chan M.M.W., Polymorphisms of superoxide dismutase and catalase genes and their functional activity levels in Chinese patients with asthma, American Thoracic Society International Conference, San Diego, USA. May 2005. Proceedings of the American Thoracic Society . 2005, p.A78.

Mak J.C.W., Leung H.C., Ho S.P., Lam W.K., Tsang K.W.T., Ip M.S.M. and Chan M.M.W., Systemic antioxidant status in Chinese patients with asthma, European Respiratory Journal. 2004, 24: Suppl 48: 509s.

Mak J.C.W., Leung C.M., Ho S.P., Lam W.K., Tsang K.W.T., Ip M.S.M. and Chan M.M.W., Systemic oxidative and antioxidative status in Chinese patients with asthma, Journal of Allergy and Clinical Immunology. 2004, 114(2): 260-264.

Mo H.Y., Xu J., Ren X.L., Zeng G.Q., Tan Y.X., Chen R.C., Chan M.M.W. and Zhong N.S., Evaluation by indirect immunofluorescent assay and enzyme linked immunosorbent assay of the dynamic changes of serum antibody responses against severe acute respiratory syndrome coronavirus , Chin Med J (Engl). 2005, 118(6): 446-50.

Tarlo S. and Chan M.M.W., Occupational Asthma, In: 2nd Edition, Occupational and Environmental Medicine. Rosenstock and Cullen, 2004.

Wang J., Law K.W., Ip M.S.M., Wu A.Y.Y., Wong M.K., Lam B., Chow K.M. and Chan M.M.W., Effect of asthma self management programme on asthma morbidity and health care utilization in adult patients admitted to hospital with acute asthma in Hong Kong: A randomized controlled trial, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A91.

Yu W.C., Hui D.S. and Chan M.M.W., Antiviral agents and corticosteroids in the treatment of severe acute respiratory syndrome (SARS) , Thorax. 2004, 59(8): 643-5.

Yu W.C., Hui D.S., Chan M.M.W. and Lai C.K.W., Editorial. Antivirals and Corticosteroids in the Treatment of Severe Acute Respiratory Syndrome (SARS)., Thorax. 2004, 59: 643-5.

Researcher : Chan MTL

List of Research Outputs

Leung A.Y.H., Chan M.T.L., Yuen K.Y., Cheng V.C.C., Chan K.H., Wong L.P., Liang R.H.S., Lie A.K.W. and Kwong Y.L., Ciprofloxacin Decreased Polyoma BK Virus Load in Patients Who Underwent Allogeneic Hematopoietic Stem Cell Transplantation, Clinical Infectious Disease. 2005, 40: 528-537.

Leung A.Y.H., Chan M.T.L. and Kwong Y.L., Genotyping of the noncoding control region of BK virus in patients with haemorrhagic cystitis after allogeneic haematopoietic stem cell transplantation, Bone Marrow Transplantation. 2005, 35: 531?532.

Leung A.Y.H., Chan M.T.L., Cheng V.C.C., Lie A.K.W., Yuen K.Y. and Kwong Y.L., Polyoma BK viruria in patients undergoing autologous hematopoietic stem cell transplantation, Bone Marrow Transplantation. 2005, 35: 1029?1030.

Leung A.Y.H., Chan M.T.L., Cheng V.C.C., Yuen K.Y. and Kwong Y.L., Quantification of Adenovirus in the Lower Respiratory Tract of Patients without Clinical Adenovirus-Related Respiratory Disease, Clinical Infectious Disease. 2005, 40: 1541-1544(online).

Researcher : Chan OO

Project Title:	Association of CpG island methylation of E-cadherin gene and Helicobacter pylori in gastric carcinogenesis
Investigator(s):	Chan OO
Department:	Medicine
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2004

Abstract:

Refer to hard copy

List of Research Outputs

Chan O.O., Chu K.M., Sun Y., Cheung K.L., Lam S.K., Yuen R.M.F., Hui W.M. and Wong B.C.Y., The association between Interleukin 1 beta polymorphism and hypermethylation at tumor suppressor genes in gastric cancer. Conference paper at the Annual Meeting of the American Gastroenterology Associatoin, Digestive Diseases Week (DDW) Chicago, Illinois, USA. May 14-19, Gastroenterology. 2005, 128(4 Suppl 2): A399.

Gu Q., Wang J., Xia H.H.X., Lin M.C., He H., Zou B., Tu S., Yang Y., Liu X.G., Lam S.K., Wong R.W.M., Chan O.O., Yuen R.M.F., Kung H. and Wong B.C.Y., Activation of the Caspase-8/Bid and Bax Pathways in Aspirin-Induced Apoptosis in Gastric Cancer, Carcinogenesis. 2005, 26(3): 541-546.

Gu Q., Xia H.H.X., Wang W., Wang J., Wong R.W.M., Chan O.O., Yuen M.F., Lam S.K., Cheung K.L., Liu X.G. and Wong B.C.Y., Effect of Cyclo-Oxygenase Inhibitors on Helicobacter pylori Susceptibility to Metronidazole and Clarithromycin, Alimentary Pharmacology and Therapeutics. 2004, 20: 675-681.

Jiang X., Tu S., Cui J., Lin M.C., Xia H.H.X., Wong R.W.M., Chan O.O., Yuen M.F., Jiang S.H., Lam S.K., Kung H., Soh J.W., Weinstein I.B. and Wong B.C.Y., Antisense Targeting Protein Kinase C Alpha and Beta1 Inhibits Gastric Carcinogenesis, Cancer Research. 2004, 64: 5787-5794.

Lai K.C., Hui W.M., Wong B.C.Y., Hu H.C., Chan O.O. and Lam S.K., Lansorprazole but not Rofecoxib reduced dyspeptic symptoms of patients on NSAIDS, Gastroenterology. 2005, 128(4 Suppl 2): A24.

Li G., Xia H.H.X., Chen M.H., Chan O.O., Cho C.H., Lam S.K., Berg D., Feng Z., Langenbach R. and Wong B.C.Y., Effects of Cyclooxygenase-1 and -2 Gene Disruption on Helicobacter pylori-Induced Inflammation, Apoptosis and Proliferation, Journal of Gastroenterology and Hepatology. 2004, 19(Suppl.): A299.

Tu S., Cui J., Liston P., Jiang X., Xu R., Lin M.C., Zhu Y.B., Zou B., Ng S.M., Jiang S.H., Xia H.H.X., Wong R.W.M., Chan O.O., Yuen R.M.F., Lam S.K., Kung H. and Wong B.C.Y., Gene Therapy for Colon Cancer by Adeno-Associated Viral Vector-Mediated Transfer of Survivin Cys84Ala Mutant, Gastroenterology. 2005, 128: 361-375.

Wong B.C.Y., Chan O.O., Wong K.W., Ching C.K., Wong R.W.M., Tam S., Lai K.C., Chan C.K., Yuen R.M.F. and Lam S.K., A pilot study of participation in faecal occult blood testing and screening colonoscopy after health education in Hong Kong, European Journal of Cancer Preview. 2005, 14(2): 181-184.

Wong R.W.M., Huang J., Xia H.H.X., Fung F.M.Y., Tong S.M., Cheung K.L., Ho Y.K., Lai K.C., Chan C.K., Chan O.O., Hui C.K., Lam S.K. and Wong B.C.Y., Low-dose rabeprazole, amoxicillin and metronidazole triple therapy for the treatment of Helicobacter pylori infection in Chinese patients , Journal of Gastroenterology and Hepatology. 2005, 20(6): 935-940.

Wong R.W.M., Lai K.C., Hui W.M., Hu H.C., Huang J., Wong Y.H., Xia H.H.X., Chan O.O., Lam S.K. and Wong B.C.Y., Pathophysiology of Gastroesophageal Reflux Diseases in ChineseRole of Transient Lower Esophageal Sphincter Relaxation and Esophageal Motor Dysfunction, American Journal of Gastroenterology. 2004, 99: 2088-2093.

Xia B., Xia H.H.X., Lam S.K., Chan O.O., Lai K.C., Hu H.C. and Wong B.C.Y., Trends in prevalence of peptic ulcer disease and Helicobacter pylori infection and frequency of NSAID intake in general practitioner-referred dyspeptic patients over 6 years in Hong Kong, Gastroenterology. 2005, 128(4 Suppl 2): A230.

Xia H.H.X., Li G., Chen M.H., Chan O.O., Cho C.H., Lam S.K., Berg D., Feng Z., Langenbach R. and Wong B.C.Y., Cyclooxygenase-1 and -2 Gene Disruption Potentiate TH1 Polarization in Response to Helicobacter pylori, Journal of Gastroenterology and Hepatology. 2004, 19(Suppl.): A366.

Xia H.H.X., Lam S.K., Chan O.O., Lin M.C., Kung H., Ogura K., Berg D.E. and Wong B.C.Y., Macrophage Migration Inhibitory Factor Stimulated by Helicobacter pylori Increases Proliferation of Gastric Epithelial Cells, World Journal of Gastroenterology. 2005, 11(13): 1946-1950.

Yong J.L., Lam C.M., Chan O.O., Poon R.T.P., Liu C.L., Lo C.M. and Fan S.T., Better survival in female patients with hepatocellular carcinoma (Abstract), Asian Journal of Surgery. 2005, 28(Suppl 2): S94.

Yong J.L., Lam C.M., Chan O.O., Poon R.T.P., Liu C.L., Lo C.M. and Fan S.T., Better survival in female patients with hepatocellular carcinoma (Abstract), The 4th International Meeting on Hepatocellular Carcinoma: Eastern and Western Experiences, Hong Kong, 14-16 December 2004.

Yuen M.F., Ng I.O.L., Fan S.T., Yuan H., Wong D.K.H., Yuen J.C.H., Sum S.M., Chan O.O. and Lai C.L., Significance of HBV DNA levels in liver histology of HBeAg and anti-HBe positive patients with chronic hepatitis B, American Journal of Gastroenterology. 2004, 99(10): 2032-2037.

Yuen R.M.F., Lim W.L., Chan O.O., Wong D.K.H., Sum S.M. and Lai C.L., 18-year follow-up study of a prospective randomized trial of hepatitis B vaccinations without booster doses in children, Clinical Gastroenterology and Hepatology. 2004, 2(10): 941-5.

Yuen R.M.F., Wong D.K.H., Sum S.M., Yuan H., Yuen J.C.H., Chan O.O., Wong B.C.Y. and Lai C.L., Effect of lamivudine therapy on the serum covalently closed circular DNA of chronic hepatitis B infection., 55th Annual Meeting of the American Association for the Study of Liver Diseases, Boston, USA 29 Oct-2 Nov 2004 (Published in Hepatology). 2004, 40(4): 671A.

Yuen R.M.F., Wong D.K.H., Sum S.M., Yuan H., Yuen J.C.H., Chan O.O., Wong B.C.Y. and Lai C.L., Effect of lamivudine therapy on the serum covalently closed-circular (ccc) DNA of chronic hepatitis B infection., American Journal of Gastroenterology. 2005, 100(5): 1099-103.

Yuen R.M.F., Yuan H., Sablon E., Wong D.K.H., Chan O.O., Wong B.C.Y. and Lai C.L., Long-term follow-up study of Chinese patients with YMDD mutations: significance of hepatitis B virus genotypes and characteristics of biochemical flares, Journal of Clinical Microbiology. 2004, 42(9): 3932-6.

Yuen R.M.F., Fung S.K., Tanaka Y., Kato T., Mizokami M., Yuen J.C.H., Wong D.K.H., Yuan H., Sum S.M., Chan O.O., Wong B.C.Y. and Lai C.L., Longitudinal study of hepatitis activity and viral replication before and after HBeAg seroconversion in chronic hepatitis B patients infected with genotypes B and C., Journal of Clinical Microbiology. 2004, 42(11): 5036-40.

Yuen R.M.F., Yuan H., Wong D.K.H., Yuen J.C.H., Wong R.W.M., Chan O.O., Wong B.C.Y., Lai K.C. and Lai C.L., Prognostic determinants for chronic hepatitis B in Asians: therapeutic implications., Gut. 2005, online.

Yuen R.M.F., Tanaka K., Mizokami M., Yuen J.C.H., Hui C.K., Wong D.K.H., Yuan H., Sum S.M., Chan O.O., Wong B.C.Y., Fan S.T. and Lai C.L., Role of hepatitis B virus genotypes Ba and C, core promoter and precore mutations on hepatocellular carcinoma: a case control study, Carcinogenesis. 2004, 25(9): 1593-1598.

Zhu S., Xia H.H.X., Lam S.K., Yu L., Yang Y., Sun Y., Wang J., Chan O.O. and Wong B.C.Y., Alterations of gastric homeoprotein expression in H. Pylori infection and/or intestinal metaplasia, Gastroenterology. 2005, 128(4 Suppl 2): A598.

Zhuang Z., Tsao G.S.W., Xia H.H.X., He H., Chan O.O., Lam S.K. and Wong B.C.Y., COX-2 inhibition induces apoptosis in human esophageal epithelial cells: implication for chemoprevention, Gastroenterology. 2005, 128(4 Suppl 2): A299.

Researcher : Chan RHW

List of Research Outputs

Siu C.W., Chan R.H.W., Tse H.F., Lau C.P., Jim M.H., Ho H.H. and Chu F., Recurrent acute heart failure caused by sliding hiatus hernia. , Postgrad Med Journal. 2005, 81(954): 268-9.

Researcher : Chan SM

List of Research Outputs

Kwok C.F., Chan S.M., Lee K.K., Ho A.Y.Y., Chan Y.Y., Li P.F., Wong Y.W., Leung F., Luk K.D.K. and Kung A.W.C., An evaluation of a secondary prevention programme against osteoporosis fractures, 6th Regional Osteoporosis Conference, 21-22 May 2005, Hong Kong. 2005.

Researcher : Chan TK

List of Research Outputs

Chan V.N.Y., Yip B., Yam I.Y.L., Au P., Lin C.K., Wong V.C.N. and Chan T.K., Carrier incidence for spinal muscular atrophy in southern Chinese, Journal of Neurology. 2004, 251: 1089-1093.

Chan V.N.Y., Yam I.Y.L., Yeung W.S.B., Ng E.H.Y., Ho P.C. and Chan T.K., Preimplantation diagnosis of homozygous alpha° thalassemia, Xth Congress of the International Society of Hematology, Asian Pacific Division, Nagoya, Japan, September. 2004.

Researcher : Chan VNY

Project Title:	Development of a microarray based assay to study epigenomic alternation in breast cancer using comparative methylation hybridization
Investigator(s):	Chan VNY, Chow LWC, Lee SMY
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002

Abstract:

To make use of the microarray techology to develop an assay that will generate the methylation profile of breast tumours that can be used for either diagnostic or prognostic evaluation in clinics.

Project Title:	Localisation of the disease or disease-susceptibility gene for adolescent idiopathic scoliosis
Investigator(s):	Chan VNY, Chan K, Lee SMY, Luk KDK
Department:	Medicine
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	11/2003

Abstract:

To identify genes along the mouse chromosome 17 (which is in synteny to human chromosome 19p), that are expressed in tissues associated with AIS phenotype, such as muscle, bone, cartilage, tendon, etc; to identify by differential gene expression analysis those genes along human chromosome 19p13, expressed (differently- decreased or increased) in AIS patients compared to human control subjects; to sequence those genes of interest in genomic DNA of the indexed patients in the relevant AIS families, in order to identify the causative mutations.

Project Title:	Localisation of the disease or disease-susceptibility gene for adolescent idiopathic scoliosis
Investigator(s):	Chan VNY, Chan K, Luk KDK, Cheng CK
Department:	Medicine
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	11/2003

Abstract:

List of Research Outputs

Chan K. and Chan V.N.Y., Microarray and diagnosis of thalassemia and haemophilia B, Xth Congress of the International Society of Hematology, Asian Pacific Division, Nagoya, Japan. 2004.

Chan V.N.Y., Yip B., Yam I.Y.L., Au P., Lin C.K., Wong V.C.N. and Chan T.K., Carrier incidence for spinal muscular atrophy in southern Chinese, Journal of Neurology. 2004, 251: 1089-1093.

Chan V.N.Y., Chairman of oral session, Xth Congress of the International Society of Hematology, Asian Pacific Division, Nagoya, Japan, September. 2004.

Chan V.N.Y., Member of International Advisory Committee, Xth Congress of the International Society of Hematology, Asian Pacific Division, Nagoya, Japan. 2004.

Chan V.N.Y., Member, Asian Network Thalassemia Control. 2005.

Chan V.N.Y., Member, Faculty Health and Safety Committee, Faculty of Medicine, HKU. 2005.

Chan V.N.Y., Member, Promotion & Tenure Panel, Faculty of Science, HKU. 2005.

Chan V.N.Y., Yam I.Y.L., Yeung W.S.B., Ng E.H.Y., Ho P.C. and Chan T.K., Preimplantation diagnosis of homozygous alpha° thalassemia, Xth Congress of the International Society of Hematology, Asian Pacific Division, Nagoya, Japan, September. 2004.

Chan V.N.Y., Reviewer, Archives of Medical Research, 2002 - to date. 2005.

Chan V.N.Y., Reviewer, International Journal of Hematology, 2003 - to date. 2005.

Gu J., Chan V.N.Y. and Kung A.W.C., Determinants of bone mineral density in early postmenopausal Asian women: The significance of family history of fracture, 6th Regional Osteoporosis Conference, 21-22 May 2005, Hong Kong. 2005.

Jin L., Lau H.L., Smith D.K., Lau K.S., Cheung P.T., Kwan E.Y.W., Low L.C.K., Chan V.N.Y. and Kung A.W.C., A family with osteoporosis-pseudoglioma syndrome (OPG) due to compound heterozygous mutation of the LRP5 gene, HKU 10th Medical Research Conference. 2005.

Jin L., Lau H.L., Smith D.K., Lau K.S., Cheung P.T., Kwan E.Y.W., Low L.C.K., Chan V.N.Y. and Kung A.W.C., Family with osteoporosis Pseudolioma Syndrome due to compound heterozygosity of two novel mutations of the LRP5 gene, 6th Regional Osteoporosis Conference, 21-22 May 2005, Hong Kong. 2005.

Kung A.W.C., Lai M.H., Lau H.L. and Chan V.N.Y., Polymorphisms in the promoter region of the estrogen receptor beta gene are associated with higher risks of osteoporosis in both men and women, Osteoporosis Global Conference, 2nd Joint Meeting of European Calcified Tissue and International Bone & Mineral Society, 25-29 June 2005, Geneva, Switzerland. 2005.

Kung A.W.C., Lau H.L., Paterson A.D., Cheung W.M.W., Luk K.D.K. and Chan V.N.Y., Test of linkage and/or association of genes and bone mineral density in Chinese, 26th Annual Meeting of the American Society for Bone & Mineral Research, October 1-5, 2004, Seattle, USA. Journal of Bone and Mineral Research. 2004, 19(Supl 1): SU159.

Lai M.H., Lau H.L., Chan V.N.Y. and Kung A.W.C., Estrogen receptor beta gene polymorphisms in the promoter region are associated with higher risks of osteoporosis in both men and women, The Endocrine Society’s 87th Annual Meeting, June 4-7, 2005, San Diego, USA. 2005.

Lai M.H., Lau H.L., Chan V.N.Y. and Kung A.W.C., Polymorphisms in the promoter region of the estrogen receptor beta gene are associated with higher risks of osteoporosis in both men and women, HKU 10th Medical Research Conference. 2005.

Lai M.H., Lau H.L., Chan V.N.Y. and Kung A.W.C., Promoter polymorphisms of the estrogen receptor beta gene are associated with higher risks of osteoporosis in both men and women, 6th Regional Osteoporosis Conference, 21-22 May 2005, Hong Kong. 2005.

Leung K.Y., Lee C.P., Tang M.H.Y., Lau E.T., Ng L.K.L., Lee Y.P., Chan H.Y., Ma E.S.K. and Chan V.N.Y., Cost-effectiveness of prenatal screening for thalassaemia in Hong Kong, Prenatal Diagnosis. 2004, 24: 899-907.

Leung K.Y., Lee C.P., Tang M.H.Y., Chan H.Y. and Chan V.N.Y., Prenatal Diagnosis of Alpha-thalassemia in a Twin Pregnancy, Ultrasound in Obstetrics & Gynecology. 2005, 25: 201-202.

Xu J., Dan Q., Chan V.N.Y., Wat N.M.S., Tam S., Tiu S.C., Lee K.F., Siu S.C., Tsang M.W., Fung L.M., Chan K.W. and Lam K.S.L., Genetic and Clinical Characteristics of Maturity-onset Diabetes of the Young in Chinese Patients, European Journal of Human Genetics. 2005, 13: 422-427.

Researcher : Chan WK

List of Research Outputs

Jin O., Chan W.K., Mok T.M.Y., Sun L.Y. and Lau W.C.S., Osteopontin (OPN), matrix metalloproteinase (MMP)-3 and lupus nephritis (LN), 11th APLAR Bi-annual Congress, Jeju, Korea 11-16 September 2004.

Lau W.C.S., Yeung J.S.L., Chan W.K. and Ren Y., Diminished macrophage (Mac) clearance of apoptotic polymorphonuclear cells (PMN) in patients with rheumatoid arthritis (RA), 11th APLAR Bi-annual Congress, Jeju, Korea 11-16 Septemer 2004.

Researcher : Chan YL

List of Research Outputs

Ho W.L., Chan Y.L., Kwok H.H., Mak W., Chu A.C.Y., Kung M.H.W., Ramsden D.B. and Ho S.L., mpp+ Modulates Mitochondrial Uncoupling Protein Ucp2, Ucp4 And Ucp5 Expression In Catecholaminergic (sk-n-sh) Cells , J Neurosci Res. 2005, 81(2): 261-8.

Ho W.L., Chan Y.L., Leung K.C., Kung M.H.W., Ramsden D.B. and Ho S.L., Potential Role Of Uncoupling Proteins, Ucp2, -4, And -5, In The Neuroprotective Effects Of Estrogen On Mpp+-induced Neurotoxicity. , 8th International Congress of Parkinson's disease & Movement Disorders, Rome, Italy. 2004.

Researcher : Chan YY

List of Research Outputs

Leung J.C.K., Chan Y.Y., Li F.K., Tang S.C.W., Chan K.W., Chan D.T.M., Lam M.F., Wieslander A. and Lai K.N., Glucose degradation products downregulate ZO-1 expression in human peritoneal mesothelial cells: the role of VEGF, Nephrology Dialysis Transplantation. 2005, 20(7): 1336-1349.

Researcher : Chau FY

List of Research Outputs

Cheung B.M.Y., Lam T.H., Lam K.S.L., Tam S., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Man Y.B., Cheng C.H., Kumana C.R. and Lau C.P., Follow Up of the Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., High Blood Pressure is Related to Obesity in Hong Kong, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Lipid Profile of the Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Obesity in the Hong Kong Cardiovascular Risk Factor Prevalence Survey-2 (CRISPS2) Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of Diabetes Mellitus (DM) in the Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Wat N.M.S., Lo L.F., Chau F.Y., Lam T.H., Leung G.M., Tam S., Cheng C.H., Kumana C.R., Lau C.P. and Lam K.S.L., Prevalence of Hypertension in Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort, J Hong Kong Coll Cardiol. 2004, 12: 33.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Relationship Between Hypertension and Obesity in Hong Kong, 3rd Asian-Pacific Congress on Hypertension, Singapore 2004.

Man Y.B., Cheung B.M.Y., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of Hypertension in the Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong. 2004.

Researcher : Chau J

List of Research Outputs

Yu C.M., Lau C.P., Chau J., McGhee S.M., Kong S.L., Cheung B.M.Y. and Li L.S.W., A short course of cardiac rehabilitation program is highly cost effective in improving long-term quality of life in patients with recent myocardial infarction or percutaneous coronary intervention, Archives of Physical Medicine and Rehabilitation. 2004, 85(12): 1915-22.

Researcher : Chen B

List of Research Outputs

Chen B., Xu A., Lam C.W., Hoo R.L.C. and Lam K.S.L., Adenovirus-mediated expression of adiponectin alleviates liver fibrosis and induces apoptosis of activated hepatic stellate cells, 10th Medical Research Conference, The University of Hong Kong. 19-20 Feb 2005. Endocrinology 23.

Hoo R.L.C., Xu A., Lam C.W., Chen B., Carling D. and Lam K.S.L., Adenovirus-mediated expression of constitutively active AMP-activated protein kinase alleviates diabetes in db/db diabetic mice, 10th Medical Research Conference, The University of Hong Kong. 19-20 Feb 2005. Endocrinology 25.

Xu A., Hoo R.L.C., Hoo R.L.C., Lam C.W., Chen B. and Lam K.S.L., Adenovirus-Mediated Expression of Adiponectin Alleviates Endothelial Dysfunction and Oxidative Stress Associated with db/db Diabetic Mice, The Endocrine Society’s 87th Annual Meeting, June 4-7, 2005, San Diego, USA. 2005.

Xu A., Lam M.C., Chan K.W., Wang Y., Zhang J.C.L., Xu J., Chen B., Chow W.S., Tso A.W. and Lam K.S.L., Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice, Proc Natl Academic Science USA. 2005, 102(17): 6086-91.

Xu A., Lam C.W., Chan K.W., Zhang J., Hoo R.L.C., Xu J., Chen B. and Lam K.S.L., Angiopoietin-like protein 4 is a novel metabolic hormone with therapeutic potentials for hyperglycemia and insulin resistance, 10th Medical Research Conference, The University of Hong Kong. 19-20 Feb 2005. Endocrinology 22.

Xu A., Chan K.W., Hoo R.L.C., Wang Y., Zhang J., Chen B., Cynthia T., Cooper G.J.S. and Lam K.S.L., Testosterone Selectively Reduces the High Molecular Weight Form of Adiponectin by Inhibiting Its Secretion from Adipocytes, The Journal of Biological Chemistry. 2005, 280: 18073-18080.

Researcher : Chen S

List of Research Outputs

Chen S. and Cheung R.T.F., Neuropeptide Y-Y1 receptor agonist worsens while antagonist improves survival of cultured Y1-expressing neuronal cells following oxygen and glucose deprivation, Journal of Biomedical Science. 2004, 11: 781-788.

Cheung R.T.F. and Chen S., Neuropeptide Y and its receptor analogs differentially modulate the immunoreactivity for neuronal or endothelial nitric oxide synthase in the rat brain following focal ischemia with reperfusion, Journal of Biomedical Science. 2005, 12: 267-278.

Researcher : Chen TM

List of Research Outputs

Kong K.P., Prokunina-Olsson L., Wong W.H.S., Lau W.C.S., Chen T.M., Alarcon-Riquelme M. and Lau Y.L., A New Haplotype of PDCD1 is Associated with Rheumatoid Arthritis in Hong Kong Chinese, Arthritis & Rheumatism. 2005, 52(4): 1058-1062.

Researcher : Chen WH

Project Title:	Enoxaparin combined with epitfibatide or abciximab versus unfractionated heparin combined with epitfibatide or abciximab in percutaneous coronary intervention: obersvations on efficacy, safety, anticoagulation profile, and level of platelet inhibition
Investigator(s):	Chen WH, Lau CP
Department:	Medicine
Source(s) of Funding:	Other Funding Scheme
Start Date:	06/2001

Abstract:

To compare the safety, efficacy, anticoagulation profile and level of platelet inhibition in patients undergoing percutaneous coronary intervention using enoxaparin/eptifibatide, unfractionated heparin/epitfibatide, enoxaparin/abciximab, and unfractionated heparin/abciximab.

Project Title:	A prospective study to investigate the determinants of the quantity of embolized debris during native vessel percutaneous coronary intervention
Investigator(s):	Chen WH, Lau CP
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002

Abstract:

To identity the clinical and lesion characteristics that determine the quantity of embolized debris captured by a distal protection device during native vessel PCI.

Project Title:	A prospective study to evaluate the relation between aspirin resistance and the incidence and magnitude of myonecrosis after percutaneous coronary intervention
Investigator(s):	Chen WH, Lau CP
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Abstract:

To compare the incidence and magnitude of myoecrosis between aspirin-sensitive and -resistant patients undergoing PCI.

List of Research Outputs

Chen W.H., Lee P.Y., Ng W., Kwok J.Y.Y., Cheng X., Tse H.F. and Lau C.P., Prevalence profile, and predictors of aspirin resistance measured by the Ultegra Rapid Platelet Function Assay-ASA in patients with coronary artery disease, J Am Coll Cardiol. 2005, 45: 382A.

Quan V.H., Huynh R., Seifert P.A., Kuchela A., Chen W.H., Sutsch G., Eisenhauer A.C. and Rogers C., Morphometric analysis of particulate debris extracted by four different embolic protection devices from coronary arteries, aortocoronary saphenous vein conduits, and carotid arteries., Am J Cardiol. 2005, 95(12): 1415-9.

Researcher : Chen X

List of Research Outputs

Li V.S.W., Wong C.W., Chan T.L., Chan A.S.W., Zhao W., Chu K.M., Chen X., Yuen S.T., Leung S.Y. and So S., Mutations of PIK3CA in gastric adenocarcinoma, BioMed Central Cancer. 2005, 5: 29.

Researcher : Cheng CH

List of Research Outputs

Cheung B.M.Y., Lam T.H., Lam K.S.L., Tam S., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Man Y.B., Cheng C.H., Kumana C.R. and Lau C.P., Follow Up of the Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., High Blood Pressure is Related to Obesity in Hong Kong, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Lipid Profile of the Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Obesity in the Hong Kong Cardiovascular Risk Factor Prevalence Survey-2 (CRISPS2) Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of Diabetes Mellitus (DM) in the Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Wat N.M.S., Lo L.F., Chau F.Y., Lam T.H., Leung G.M., Tam S., Cheng C.H., Kumana C.R., Lau C.P. and Lam K.S.L., Prevalence of Hypertension in Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort, J Hong Kong Coll Cardiol. 2004, 12: 33.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Relationship Between Hypertension and Obesity in Hong Kong, 3rd Asian-Pacific Congress on Hypertension, Singapore 2004.

Cheung B.M.Y., Lam T.H., Lam K.S.L., Tam S., Wat N.M.S., Man Y.B., Cheng C.H., Kumana C.R. and Lau C.P., The Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort - Results at 7 Years, J Hypertens. 2004, 22 (Suppl 2): S268-269.

Man Y.B., Cheung B.M.Y., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of Hypertension in the Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong. 2004.

Researcher : Cheng CK

Project Title:	Epigenetic and genetic regulation of the cell cycle checkpoint protein Rad9 in breast cancer
Investigator(s):	Cheng CK, Chan VNY, Chow LWC
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004
Completion Date:	04/2006

Abstract:

To explore the potential usefulness of Rad9 as a molecular marker for breast cancer.

List of Research Outputs

Researcher : Cheng KY

List of Research Outputs

Lam K.S.L., Dan Q., Xu A., Shen J., Cheng K.Y. and Xu J., Adiponectin stimulates the production o fmaganese superoxide dismutase (SOD2) in human aortic smooth muscle cells, 12th International Congress of Endocrinology, Aug 31 – Sep 4, 2004, Lisbon, Portugal. 2004, A442(1242).

Tso A.W.K., Wat N.M.S., Xu A., Sham P.C., Rong R., Cheng K.Y., Fong H.Y., Janus E.D. and Lam K.S.L., The adiponectin gene G276T polymorphism is a risk factor for the development of the metabolic syndrome over a period of 5 years in southern Chinese, 12th International Congress of Endocrinology, Aug 31 – Sep 4, 2004, Lisbon, Portugal. 2004, 318 P949.

Wat N.M.S., Tso A.W.K., Xu A., Sham P.C., Rong R., Cheng K.Y., Fong H.Y., Janus E.D. and Lam K.S.L., The adiponectin gene T45G polymorphism is associated with central obesity and persistent glucose intolerance in high-risk Chinese subjects over 5 years, 12th International Congress of Endocrinology, Aug 31 – Sep 4, 2004, Lisbon, Portugal. 2004.

Xu J., Wat N.M.S., Xu A., Cheng K.Y., Sham P.C., Janus E.D. and Lam K.S.L., The G/G Genotype of the -420 C→G Polymorphism in the Resistin Gene Promoter Is Associated with Post-Challenge Glycaemia in Southern Chinese, The Endocrine Society’s 87th Annual Meeting, June 4-7, 2005, San Diego, USA. 2005.

Xu J., Wat N.M.S., Xu A., Cheng K.Y., Sham P.C., Janus E.D. and Lam K.S.L., The G/G genotype of the ->G polymorphism in the resistin gene promoter is associated with post-challenge glycaemia in Southern Chinese, 10th Medical Research Conference, The University of Hong Kong. 19-20 Feb 2005. Endocrinology 26.

Researcher : Cheng SW

List of Research Outputs

Lui S.L., Cheng S.W., Ng E., Yip P.S., Tse K.C., Lam M.F., Lai K.N. and Lo W.K., A randomized prospective comparison of intraperitoneal cefazolin plus netilimicin versus cefazolin plus ceftazidime in the treatment of CAPD peritonitis, Nephrology Dialysis Transplantation. 2005, 10 (suppl): A68.

Researcher : Cheng X

List of Research Outputs

Chen W.H., Lee P.Y., Ng W., Kwok J.Y.Y., Cheng X., Tse H.F. and Lau C.P., Prevalence profile, and predictors of aspirin resistance measured by the Ultegra Rapid Platelet Function Assay-ASA in patients with coronary artery disease, J Am Coll Cardiol. 2005, 45: 382A.

Researcher : Cheung BMY

Project Title:	Hong Kong cardiovascular risk factor prevalence study-2 (CRISPS-2)
Investigator(s):	Cheung BMY, Lam KSL, Lau CP, Cheng CH, Tam S, Wat NMS, Lam TH
Department:	Medicine
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	10/2001

Abstract:

To determine the cumulative incidence of hypertension and diabetes, which are risk factors for cardiovascular diseases, in the cohort of subjects recruited in the Hong Kong Cardiovascular Risk Factor Prevalence Study in 1995-6; to determine the incidence of cardiovascular and non-cardiovascular diseases since the Hong Kong Cardiovascular Risk Factor Prevalence Study in 1995-6; to analyse the baseline factors to see if they are predictors of hypertension and diabetes, and if so, to quantify the risk and to study their interactions; to measure changes in baseline risk factors, which may have important consequences on public health.

Project Title:	Hypertension genes in Hong Kong Chinese
Investigator(s):	Cheung BMY, Lau CP
Department:	Medicine
Source(s) of Funding:	Low Budget High Impact Programme
Start Date:	11/2001

Abstract:

To study several new candidate genes that have been identified in whole genome search. By targeting specific candidate genes in our large bank of accurately defined hypertensive patients and normal controls, we can achieve high power in either confirming or refuting their association with hypertension in a Chinese population.

Project Title:	Advantages of blood pressure optimisation
Investigator(s):	Cheung BMY, Lau CP, Tse HF
Department:	Medicine
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2003

Abstract:

To compare optimal blood pressure control with conventional blood pressure targets in hypertensive patients in terms of target organ damage and tolerability.

Project Title:	Does urotensin II, the most potent vasoconstrictor known, cause high blood pressure?
Investigator(s):	Cheung BMY
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003
Completion Date:	10/2004

Abstract:

To confirm that plasma urotensin II is raised in hypertension in man and to identify the factors leading to its elevation in vivo; to study the promoter region of the urotensin II gene, identify single nucleotide polymorphisms in Hong Kong Chinese and correlate these with plasma urotensin II level and blood pressure; to study in vitro, in a cell culture model, how the gene expression of urotensin II is altered by factors known to be important in hypetension.

Project Title:	A gene locus for hypertension and obesity on chromosome 17
Investigator(s):	Cheung BMY
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Abstract:

To identify single nucleotide Polymorphisms in the 17p12 region of chromosome 17 associated with hypertension and obesity; to assess their functional significance in relation to blood pressure, obesity and relevant metabolic and hormonal variables.

List of Research Outputs

Ambekar C.S., Lee J.S.K., Cheung B.M.Y., Chan L.C., Liang R.H.S. and Kumana C.R., Metabolism of Chloramphenicol Succinate, a Competitive Substrate and Inhibitor of Succinate Dehydrogenase: Possible Reason for its Toxicity, Toxicology in Vitro. 2004, 18: 441-7.

Cheung B.M.Y., Wong L.Y.F., Li Y.Y. and Tang F., Adenomedullin expression and cytokine response in experimentally induced endotoxaemia, 4th Symposium of Adrenomedullin and Proadrenomedullin N-20 peptide, Zurich. P16. 2004.

Cheung B.M.Y., Li Y.Y. and Wong L.Y.F., Adrenomedullin: Its Roles in the Cardiovascular System, Seminars Vasc Med. 2004, 4(2): 129-134.

Cheung B.M.Y., Man Y.B., Tse H.F., Kumana C.R. and Lau C.P., Advantages of Blood Pressure Optimisation Study, J Hong Kong Coll Cardiol . 2004, 12: 33.

Cheung B.M.Y., Leung Y.H., Man Y.B., Wong L.Y.F. and Lau C.P., Association of Blood Pressure and Obesity with a Single Nucleotide Polymorphism at 17p12, American Journal of Hypertension. 2005, 18(5) Suppl: A79.

Cheung B.M.Y., Leung Y.H., Man Y.B. and Lau C.P., Association of Essential Hypertension with the WNK4 Gene, the Molecular Switch Controlling Renal Sodium and Potassium Excretion, Cardiovasc Drugs Thera. 2004, 18 (Suppl) 1: 8.

Cheung B.M.Y., Man Y.B., Leung Y.H. and Wong L.Y.F., Association of Single Nucleotide Polymorphisms in the Urotensin II Gene with Plasma Insulin and Hypertension, American Journal of Hypertension. 2005, 18: 79A.

Cheung B.M.Y., Beta-Blockers a Second Rate Treatment for Hypertension?, J HK Coll Cardiol. 2005, 13: 1-3.

Cheung B.M.Y., Leung Y.H., Man Y.B. and Wong L.Y.F., Elevated Plasma Concentration of Urotensin II in Hypertension, 3rd Asian-Pacific Congress on Hypertension, Singapore 2004.

Cheung B.M.Y., Leung Y.H., Man Y.B. and Wong L.Y.F., Elevated Plasma Concentration of Urotensin II in Hypertension, J Hypertens. 2004, 22 (Suppl 2): S188.

Cheung B.M.Y., Lam T.H., Lam K.S.L., Tam S., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Man Y.B., Cheng C.H., Kumana C.R. and Lau C.P., Follow Up of the Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., High Blood Pressure is Related to Obesity in Hong Kong, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Au T.H.Y., Chan S.Y., Lam C.M., Lau S.H., Lee R.P., Lee S.F., Lo W.S., Sin E.H.F., Tang M.Y. and Tsang H.H., Hypertension is Associated with Anxiety But Not Depression in Hong Kong Chinese, 3rd Asian-Pacific Congress on Hypertension, Singapore 2004.

Cheung B.M.Y., Au T.H.Y., Chan S.Y., Lam C.M., Lau S.H., Lee R.P., Lee S.F., Lo W.S., Sin E.H.F., Tang M.Y. and Tsang H.H., Hypertension is associated with increased anxiety but not depression in Hong Kong, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong. 2004.

Cheung B.M.Y., Hwang I.S.S., Li C., Tsang K.W.T., Leung Y.H., Kumana C.R. and Tang F., Increased Adrenomedullin Expression in Lungs in Endotoxaemia, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong. 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Lipid Profile of the Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Cheung G.T.Y., Lauder I.J., Lau C.P. and Kumana C.R., Meta-analysis of Large Outcome Trials of Angiotensin Receptor Blockers in Hypertension, American Journal of Hypertension. 2005, 18(5) Suppl: A53.

Cheung B.M.Y., Lauder I.J. and Kumana C.R., Meta-analysis of Large Randomised Controlled Trials that Evaluate Cardiovascular Outcomes After Stain Treatment, 8th Scientific Meeting of the Hong Kong Pharmacology Society in Association with the Shanghai Pharmacology Society, Hong Kong 2004.

Cheung B.M.Y., Lauder I.J. and Kumana C.R., Meta-analysis of Large Randomised Controlled Trials to Evaluate the Impact of Statins on Cardiovascular Outcomes, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong. 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Obesity in the Hong Kong Cardiovascular Risk Factor Prevalence Survey-2 (CRISPS2) Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Leung Y.H., Man Y.B. and Wong L.Y.F., Plasma Concentration of Urotensin II is Raised in Hypertension, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong. 2004.

Cheung B.M.Y., Leung Y.H., Man Y.B. and Wong L.Y.F., Plasma Concentration of Urotensin II is Raised in Hypertension, J Hypertens. 2004, 22: 1341-4.

Cheung B.M.Y., Man Y.B., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of Diabetes Mellitus (DM) in the Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Wat N.M.S., Lo L.F., Chau F.Y., Lam T.H., Leung G.M., Tam S., Cheng C.H., Kumana C.R., Lau C.P. and Lam K.S.L., Prevalence of Hypertension in Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort, J Hong Kong Coll Cardiol. 2004, 12: 33.

Cheung B.M.Y., Law C.Y., Ho G.Y.Y., McGhee S.M., Man Y.B., Ng P.P.Y., Kumana C.R. and Lau C.P., Randomised Controlled Trial of Low Salt Diet Versus Drug Treatment in the Management of Mild hypertension, 8th Scientific Meeting of the Hong Kong Pharmacology Socieity in Association with the Shanghai Pharmacology Society, Hong Kong 2004.

Cheung B.M.Y., Lo L.F., Fong D.Y.T., Chan M.Y., Wong W.H.S., Lau C.P., Lam K.S.L., Wong V.C.N. and Karlberg J.P.E., Randomised Controlled Trial of Qigong in Hypertension, Cardiovasc Drugs Thera. 2004, 28 (suppl) 1: 28.

Cheung B.M.Y., Lo L.F., Fong D.Y.T., Chan M.Y., Wong W.H.S., Lau C.P., Lam K.S.L., Wong V.C.W. and Karlberg J.P.E., Randomised controlled trial of qigong in hypertension, J Hong Kong Coll Cardiol. 2004, 12: 34.

Cheung B.M.Y., Lo L.F., Fong D.Y.T., Chan M.Y., Wong S.H.T., Wong V.C.W., Lam K.S.L., Lau C.P. and Karlberg J.P.E., Randomised controlled trial of qigong in the treatment of mild essential hypertension, J Hum Hypertens. 2005, 19(9): 697-704.

Cheung B.M.Y., Law C.Y., Ho G.Y.Y., McGhee S.M., Man Y.B., Ng P.P.Y., Kumana C.R. and Lau C.P., Randomsed Controlled Trial of Low Salt Diet Versus Drug Treatment in Hypertension, Cardiovasc Drugs Thera. 2004, 18 (Suppl) 1: 15.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Relationship Between Hypertension and Obesity in Hong Kong, 3rd Asian-Pacific Congress on Hypertension, Singapore 2004.

Cheung B.M.Y., Sartans for Hypertension - Implications of the Valsartan Antihypertensive Long-Term Use Evaluation, Hong Kong Medical Journal. 2004, 10(5): 359.

Cheung B.M.Y., Lam T.H., Lam K.S.L., Tam S., Wat N.M.S., Man Y.B., Cheng C.H., Kumana C.R. and Lau C.P., The Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort - Results at 7 Years, J Hypertens. 2004, 22 (Suppl 2): S268-269.

Cheung B.M.Y., Au T.H.Y., Chan S.Y., Lam C.M., Lau S.H., Lee R.P., Lee S.F., Lo W.S., Sin E.H.F., Tang M.Y. and Tsang H.H., The Relationship Between Hypertension, Anxiety and Depression In Hong Kong Chinese, Exp Clin Cardiol. 2005, 10(1): 21-24.

Cheung B.M.Y., Law C.Y., McGhee S.M., Ng P.P.Y., Kumana C.R. and Lau C.P., The Relationship Between Sodium and Blood Pressure in Hong Kong Chinese, Clin Res Regul Aff. 2004, 21(2): 145-154.

Hui C.K., Cheung B.M.Y. and Lau G., Pharmacokinetics of pitavastatin in subjects with Child-Pugh A and B cirrhosis, Br J Clin Pharmacol. 2005, 59: 291-7.

Hung I.F.N. and Cheung B.M.Y., A Review on Lopinavir/Ritonavir, Medical Progress. 2005, 32: 345-8.

Kumana C.R., Cheung G.T.Y., Lauder I.J. and Cheung B.M.Y., Long-term combination therapy with aspirin and clopidogrel, J Cardiovasc Pharmacol Ther. 2004, 9(4): 223-5.

Kumana C.R., Cheung B.M.Y., Cheung G.T.Y., Ovedal T., Pederson B. and Lauder I.J., Rhythm vs.rate control of atrial fibrillation meta-analysed by number needed to treat, Br J Clin Pharmacol. Blackwell Publishing Ltd, 2005, 60(4): 347-54.

Man Y.B., Wong L.Y.F. and Cheung B.M.Y., Association of Urotensin II rs7367534 C>T Polymorphism with Hypertension, J HK Coll Cardiol . 2004, 12: 110.

Man Y.B., Cheung B.M.Y., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of Hypertension in the Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong. 2004.

Ong K.L., Wong L.Y.F., Man Y.B., Lam K.S.L. and Cheung B.M.Y., Hypertension is associated with a single nucleotide polymorphism in the uroteinsin II gene, 10th Medical Research Conference, The University of Hong Kong. 19-20 Feb 2005.

Ong K.L., Cheung B.M.Y. and Lam K.S.L., Urotensin II and the Circulatory System, Hong Kong J Nephrol . 2005, 7: 9-14.

Ong K.L., Lam K.S.L. and Cheung B.M.Y., Urotensin II: Its Function in Health and Its Role in Disease, Cardiovascular Drugs Therapy. 2005, 19(1): 65-75.

Rong R., Xu A., Cheung B.M.Y., Cheung G. and Lam K.S.L., Identification of Three Novel Missense Mutations of the Human Melanocortin-4 Receptor Gene in a Chinese Obesity Population, Endocrine Society's 86th Annual Meeting, New Orleans 2004.

Wong L.Y.F., Cheung B.M.Y., Li Y.Y. and Tang F., Adrenomedullin expression and its effects on cytokine response of rat macrophages to lipopolysaccharide, 4th Symposium of Adrenomedullin and Proadrenomedullin N-20 peptide, Zurich. S20. 2004.

Wong L.Y.F., Cheung B.M.Y. and Tang F., Adrenomedullin is Both Proinflammatory and Antiinflammatory: Its Effects on Gene Expression and Secretion of Cytokines and Macrophage Migration Inhibitory Factor in NR8383 Macrophage Cell Line, Endocrinology. 2005, 146: 1321-1327.

Wong L.Y.F., Cheung B.M.Y. and Tang F., Expressions of Urotensin II and Urotensin II Receptor are Up-regulated in Cardiovascular Tissues in Experimentally Induced Endotoxaemia, American Journal of hypertension. 2005, 18: 125A.

Wong L.Y.F., Man Y.B., Leung Y.H. and Cheung B.M.Y., Interleukin-6 Gene -573G>C Promoter Polymorphism is Associated with Plasma Fibrinogen Level and Hypertension in Hong Kong Chinese, American Journal of Hypertension. 2005, 18: 186A.

Wong L.Y.F., Cheung B.M.Y., Li C. and Tang F., Temporal Changes in Cytokine Levels in Plasma and Various Peripheral Tissues of Rat After Treatment with Lipopolysaccharide, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong. 2004.

Wong Y.L. and Cheung B.M.Y., Utilisation of Antihypertensive Drugs in a Hypertension Outpatient Clinic in 1998 and 2004, Cardiovasc Drugs Thera. 2004, 18 (Suppl) 1: 23.

Yu C.M., Lau C.P., Chau J., McGhee S.M., Kong S.L., Cheung B.M.Y. and Li L.S.W., A short course of cardiac rehabilitation program is highly cost effective in improving long-term quality of life in patients with recent myocardial infarction or percutaneous coronary intervention, Archives of Physical Medicine and Rehabilitation. 2004, 85(12): 1915-22.

Researcher : Cheung GTY

List of Research Outputs

Au W.Y., Cheung G.T.Y., Yuen W.H., Kumana C.R. and Kwong Y.L., Successful treatment of relapsed acute promyelocytic leukemia in a patient receiving continuous ambulatory peritoneal dialysis with oral arsenic trioxide, Archite Internal Medicine. 2005, 165: 1067-1068.

Chan L.S., Cheung G.T.Y., Lauder I.J. and Kumana C.R., Screening For Fever By Remote Sensing Infrared Thermographic Camera, Journal of Travel Medicine. 2004, 11: 273-297.

Cheung B.M.Y., Cheung G.T.Y., Lauder I.J., Lau C.P. and Kumana C.R., Meta-analysis of Large Outcome Trials of Angiotensin Receptor Blockers in Hypertension, American Journal of Hypertension. 2005, 18(5) Suppl: A53.

Kumana C.R., Cheung G.T.Y., Lauder I.J. and Cheung B.M.Y., Long-term combination therapy with aspirin and clopidogrel, J Cardiovasc Pharmacol Ther. 2004, 9(4): 223-5.

Kumana C.R., Cheung B.M.Y., Cheung G.T.Y., Ovedal T., Pederson B. and Lauder I.J., Rhythm vs.rate control of atrial fibrillation meta-analysed by number needed to treat, Br J Clin Pharmacol. Blackwell Publishing Ltd, 2005, 60(4): 347-54.

Kumana C.R., Cheung G.T.Y., Lauder I.J. and Chan L.S., Screening for Fever by Means of Infrared Thermographic Camera, 11th Ineternational Congress of infectious diseases – Mexico 2004 (Published in: International Journal of Infectious Diseases). 2004, 8(Supl 1): S110.

Kumana C.R., Cheung G.T.Y. and Lau W.C.S., Severe digital ischaemia treated with phosphodiesterase inhibitors, Annals of Rheumatic Diseases. 2004, 63: 1522-1524.

Researcher : Cheung KL

List of Research Outputs

Chan O.O., Chu K.M., Sun Y., Cheung K.L., Lam S.K., Yuen R.M.F., Hui W.M. and Wong B.C.Y., The association between Interleukin 1 beta polymorphism and hypermethylation at tumor suppressor genes in gastric cancer. Conference paper at the Annual Meeting of the American Gastroenterology Associatoin, Digestive Diseases Week (DDW) Chicago, Illinois, USA. May 14-19, Gastroenterology. 2005, 128(4 Suppl 2): A399.

Gu Q., Xia H.H.X., Wang W., Wang J., Wong R.W.M., Chan O.O., Yuen M.F., Lam S.K., Cheung K.L., Liu X.G. and Wong B.C.Y., Effect of Cyclo-Oxygenase Inhibitors on Helicobacter pylori Susceptibility to Metronidazole and Clarithromycin, Alimentary Pharmacology and Therapeutics. 2004, 20: 675-681.

Wong R.W.M., Huang J., Xia H.H.X., Fung F.M.Y., Tong S.M., Cheung K.L., Ho Y.K., Lai K.C., Chan C.K., Chan O.O., Hui C.K., Lam S.K. and Wong B.C.Y., Low-dose rabeprazole, amoxicillin and metronidazole triple therapy for the treatment of Helicobacter pylori infection in Chinese patients , Journal of Gastroenterology and Hepatology. 2005, 20(6): 935-940.

Researcher : Cheung RTF

Project Title:	Neuroprotective potential of neuropeptide Y-Y1 receptor inhibition
Investigator(s):	Cheung RTF
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002
Completion Date:	10/2004

Abstract:

To explore the neuroprotective potential of NPY-Y1 receptor inhibition in both in vivo and in vitro stroke models.

Project Title:	Cognitive impairment and dementia among stroke patients in Hong Kong
Investigator(s):	Cheung RTF
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Abstract:

To study: (1) the prevalence and risk factors of vascular cognitive impairment and dementia in Chinese stroke patients and (2) the incidence and risk factors of vascular cognitive impairment and dementia upon follow up of Chinese stroke patients without dementia during initial assessment.

Project Title:	Use of functional magnetic resonance imaging to predict benefits of acupuncture for stroke patients with persistent motor or language deficits
Investigator(s):	Cheung RTF, Li LSW, Yang ES, Leung KP, Li G, Au Yeung K.M.
Department:	Medicine
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	10/2004

Abstract:

To use functional magnetic resonance imaging (MRI) to identify stroke patients with or without activations of brain sites relevant to their persistent arm paralysis or language impairment during stimulation of the deficit-implicated acupoints and then apply randomized, double-blinded, acupoint-controlled clinical trials to confirm the benefits of acupuncture in post-stroke rehabilitation of the deficit. The results will confirm the value of functional MRI in identifying responders to acupuncture in post-stroke motor or language rehabilitation and reveal the benefit of acupuncture treatment over certain disease-implicated acupoints.

Project Title:	Role of ischemia in Alzheimer's disease - an experimental study in transgenic mice
Investigator(s):	Cheung RTF
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Abstract:

To study (1) the influence of genotype on the cerebral blood flow and infarct volume of transgenic mice overexpressing amyloid precursor protein (APP) alone or with human mutant presenilin-1 (PS-1) gene following photothrombotic stroke, and to study (2) the effects of photothrombotic stroke on the sensorimotor functions and visuospatial memory in the APP transgenic mice and APP/PS-1 double transgenic mice.

Project Title:	Use of functional magnetic resonance imaging to predict benefits of acupuncture for stroke patients with persistent motor or language deficits
Investigator(s):	Cheung RTF
Department:	Medicine
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

Refer to hard copy

List of Research Outputs

Chan K.H., Cheung R.T.F., Au Yeung K.M., Mak W., Cheng T.S. and Ho S.L., A lady with suicidal history presented with speech and walking difficulties, Journal of Clinical Neuroscience. 2005, 12: 303-305.

Chan K.H., Cheung R.T.F., Mak W., Lee R., Fong C.Y., Cheng T.S. and Ho S.L., Cerebral infarction complicating tuberculous meningitis (TBM), 17th Annual Scientific Meeting, The Hong Kong Neurological Society. 2004, 10: 8.

Chan K.H., Cheung R.T.F., Lee R., Mak W., Cheng T.S. and Ho S.L., Cerebral infarcts complicating tuberculous meningitis, Cerebrovascular Diseases. 2005, 19: 391-395.

Chan K.H., Cheung R.T.F., Lui W.M., Mak W. and Ho S.L., Cerebral venous thrombosis in a gentleman with fever, convulsion and frontotemporal haemorrhages, Journal of Clinical Neuroscience. 2005, 12: 186-188.

Chan K.H., Tsang K.L., Fong C.Y., Cheung R.T.F. and Ho S.L., Idiopathic severe recurrent transverse myelitis: a restricted variant of neuromyelitis optica, Clinical Neurology and Neurosurgery. 2005, 107: 132-135.

Chan K.H., Mak W., Cheng T.S., Cheung R.T.F. and Ho S.L., Natural course of patients with acute myelitis, 17th Annual Scientific Meeting, The Hong Kong Neurological Society. 2004, 10: 6.

Chan K.H., Cheung R.T.F., AuYeung K.M., Mak W. and Ho S.L., Wilson's Disease With Depression And Parkinsonism., J Clin Neurosci. 2005, 12(3): 303-5.

Chen S. and Cheung R.T.F., Neuropeptide Y-Y1 receptor agonist worsens while antagonist improves survival of cultured Y1-expressing neuronal cells following oxygen and glucose deprivation, Journal of Biomedical Science. 2004, 11: 781-788.

Cheung R.T.F., Acute Stroke Management, Healthy Aging: Joint Scientific Meeting of the Centre of Endocrinology & Diabetes, Institute of Cardiovascular Basic Physician Training, Hong Kong Region (West). 2004.

Cheung R.T.F., Advances in Stroke Management, Novel Treatment of Neurological Disease, Joint Scientific Meeting, Hong Kong College of Physicians and Hong Kong College of Paediatrcians. 2004.

Cheung R.T.F., Advances in stroke management, Joint Scientific Meeting on “Novel Treatment of Common Medical Disorders”, Hong Kong College of Physicians & Hong Kong College of Paediatricians. 2004, 13.

Cheung R.T.F., Cerebral Disease in Diabetes, Symposium on Neurology & Diabetes, ABC Series of Symposia on Diabetes: “N”, Diabetes Division of the Hong Kong Society of Endocrinology, Metabolism and Reproduction. 2004.

Cheung R.T.F., Cerebral Perfusion Parameters in Acute, Subacute, or Chronic Middle Cerebral Artery Territory Ischemia, Symposium A1 on Stroke Diagnosis, Sino-British Joint Conference on Neurology 2004. 2004.

Cheung R.T.F., Cerebral perfusion parameters in acute, subacute, or chronic middle cerebral artery territory ischemia, Sino-British Joint Conference on Neurology. 2004, 34-35.

Cheung R.T.F., Cerebrovascular Disease, Men’s Health, The Federation’s Annual Scientific Meeting 2004, The Federation of Medical Societies of Hong Kong. 2004.

Cheung R.T.F., Cerebrovascular disease, Men’s Health, The Federation’s Annual Scientific Meeting. 2004, 12.

Cheung R.T.F., Chairman of Organizing Committee, 17th Annual Scientific Meeting, The Hong Kong Neurological Society. 2004.

Cheung R.T.F., Chairman of Organizing Committee, The Hong Kong Stroke Symposium & Workshop 2004. 2004, 5.

Cheung R.T.F., Chairman of Scientific Session, Third Quarterly Scientific Meeting, Hong Kong Stroke Society. 2004.

Cheung R.T.F., Chairman of Session, Frontiers in Biomedical Research. 2004.

Cheung R.T.F., Chairman of Session, New Diagnostic and Therapeutic Techniques for Aging Diseases, Joint Clinical Symposium of Heart, Brain, Hormone and Healthy Aging Center of HKU and Mayo Clinic. 2004.

Cheung R.T.F., Chairman, Neurology Journal Club on The Role of Acetylcholinesterase Inhibitor in the Treatment of Vascular Dementia. 2005.

Cheung R.T.F., Chairman, Round Table Discussion on Impact of Antihypertensive and Lipid Lowering Agents on Carotid Atherosclerosis and Intima Media Thickness. 2005.

Cheung R.T.F., Chairperson of a Session, The Second Asia Pacific Conference Against Stroke. 2005.

Cheung R.T.F., Current CT & MRI Techniques in Stroke, Symposium on Up-to-date Neuroimaging of Cerebrovascular Disease, The Second Asian Pacific Congress Against Stroke, Chiangmai, Thailand. 2005.

Cheung R.T.F., Editor of Program Book, Hong Kong Stroke Symposium & Workshop 2004. 2004, 5.

Cheung R.T.F., Editorial Board, MIMS Neurology & Psychiatry Guide. 2004.

Cheung R.T.F., Editorial Board, Reviews on Recent Clinical Trials. 2005.

Cheung R.T.F., Editorial Board, Stroke. 2005.

Cheung R.T.F., European Stroke Initiative Recommendations for Stroke Management – Update 2003, Official Chinese Translation for European Stroke Initiatives. 2005.

Cheung R.T.F., Faculty Member, Chairman of Session, The First Global Conference on Cardiovascular Clinical Trials and Pharmacotherapy, The Second World Heart Federation Global Conference on Cardiovascular Clinical Trials, and the 13th International Society of Cardiovascular Pharmacotherapy Congress. 2004.

Cheung R.T.F., Functional Imaging in Cerebrovascular Disease, Symposium III on Functional Imaging, Stents and Stroke Center, Hong Kong Stroke Symposium and Workshop 2004. 2004.

Cheung R.T.F., Functional MRI and acupuncture in recovery after stroke, Frontier in Biomedical Research, HKU 2004. 52.

Cheung R.T.F., Functional MRI and acupuncture in recovery after stroke, Healthy Aging: Joint Scientific Meeting of the Centre of Endocrinology & Diabetes, Institute of Cardiovascular Science & Medicine and Neuroscience Research Centre, Frontiers in Biomedical Research. 2004.

Cheung R.T.F. and Lo G.M.Y.G., Functional imaging in cerebrovascular disease, Hong Kong Stroke Symposium & Workshop 2004. 5: 27-28.

Cheung R.T.F., Local Experience of Thrombolysis for Ischaemic Stroke, Scientific Symposium, Hong Kong Society of Critical Care Medicine. 2004.

Cheung R.T.F., Melatonin Protects Against Focal Ischemic/Reperfusion Injury in the Rat, Symposium on Physiological Basis of Melatonin Function, Shanghai International Conference on Physiological Biophysics. 2004.

Cheung R.T.F., Melatonin protects against focal ischemic/reperfusion injury in the rat, Shanghai International Conference on Physiological Biophysics. 2004, 44.

Cheung R.T.F., Member of Organizing Committee and Publicity Subcommittee, Brain Awareness Week 2005. 2005.

Cheung R.T.F., Mystery of recurrent stroke – a young lady’s case. Part II, Ming Pao Weekly (Chinese Magazine). 2005.

Cheung R.T.F., Mystery of recurrent stroke – a young lady’s case. Part I, Ming Pao Weekly (Chinese Magazine). 2005.

Cheung R.T.F. and Chen S., Neuropeptide Y and its receptor analogs differentially modulate the immunoreactivity for neuronal or endothelial nitric oxide synthase in the rat brain following focal ischemia with reperfusion, Journal of Biomedical Science. 2005, 12: 267-278.

Cheung R.T.F., Organizer and Chairman, Roundtable Meeting on Medical Management of Intracranial Artery Stenosis. 2005.

Cheung R.T.F., Organizer and Chairman, Scientific Meeting on Secondary Risk Prevention in Stroke, The Hong Kong Neurological Society. 2005.

Cheung R.T.F., Perfusion CT in acute or chronic cerebral ischemia and brain activations on functional MRI during acupuncture, Second Asian Pacific Conference Against Stroke. 2005, 83.

Cheung R.T.F., Prophylaxis and Treatment - Information for doctors in hospitals and practice - Update 2003/2004 - PDF Flyer of European Stroke Initiative, Official Chinese Translation for European Stroke Initiatives. 2005.

Cheung R.T.F., Stroke Prevention, University Health Service, University of Hong Kong. 2004.

Cheung R.T.F., Stroke – the third leading cause of death, Metro Daily (Chinese Newspaper) . 2004, 26, 41.

Cheung R.T.F., Thrombolytic Therapy For Acute Ischaemic Stroke – We Are Not Ready!, Controversies in Stroke Management, Second Quarterly Scientific Meeting 2004, Hong Kong Stroke Society. 2004.

Cheung R.T.F. and Cheng P.W., Thrombolytic and interventional therapy for acute ischaemic stroke – are we ready in Hong Kong?, 17th Annual Scientific Meeting, The Hong Kong Neurological Society. 2004, 10: 21.

Cheung R.T.F., Thrombolytic and interventional therapy for acute ischaemic stroke – are we ready in Hong Kong?, Symposium on Stroke, 17th Annual Scientific Meeting, The Hong Kong Neurological Society. 2004.

Cheung R.T.F., Update in Stroke Management, Continuous Medical Education in Internal Medicine 2004/2005, Internal Medicine Service, Centro Hospitalar C.S. Januario, Government of Macau Special Administrative Region. 2004.

Cheung R.T.F., Update on management of dementia, Medical Progress. 2004, 31: 453-460.

Khong P.L., Zhou L.J., Ooi C.G.C., Chung B.H.Y., Cheung R.T.F. and Wong V.C.N., The Evaluation of Wallerian Degeneration in Chronic Paediatric Middle Cerebral Artery Infarction Using Diffusion Tensor MR Imaging, Cerebrovascular Diseases. Karger, 2004, 18: 240-247.

Li G., Cheung R.T.F., Au Yeung K.M. and Yang E.S., An fMRI Study of sensorimotor deficit-related acupoints in stroke patients with persistent motor deficits, Society for Neuroscience 2004. 263.7.

Mak W., Tsang K.L., Tsoi T.H., AuYeung K.M.A., Chan K.H., Cheng T.S., Cheung R.T.F. and Ho S.L., Bath-related Headache, Cephalalgia. 2005, 25(3): 191-8.

Mak W., Chan K.H., Cheung R.T.F. and Ho S.L., Hypertensive encephalopathy: BP lowering complicated by posterior circulation ischemic stroke, Neurology. 2004, 63: 1131-1132.

Mak W., Cheung R.T.F. and Ho S.L., Racial/ethnic differences in cerebrovascular disease – HK perspective, Hong Kong Stroke Symposium & Workshop 2004. 5: 42-46.

Mak W., Cheung R.T.F. and Ho S.L., Riches-Cannieu anastomosis: an electrophysiology study in Hong Kong Chinese and its implications in carpal tunnel syndrome, 17th Annual Scientific Meeting, The Hong Kong Neurological Society. 2004, 10: 11.

Mak W., Cheung R.T.F. and Ho S.L., Why is intracranial large-artery steno-occlusive disease more common in Asians? A human evolutionary hypothesis and its implications, 17th Annual Scientific Meeting, The Hong Kong Neurological Society. 2004, 10: 29.

Mak W., Tsang K.L., Tsoi T.H., Au Yeung K.M., Chan K.H., Cheng T.S., Cheung R.T.F. and Ho S.L., “Thundery Shower”: a novel headache syndrome, 17th Annual Scientific Meeting, The Hong Kong Neurological Society. 2004, 10: 30.

Ng P.W., Huang C.Y., Cheung R.T.F., Wong K.S., Wong C.K. and Lam J.M., Transient ischaemic attack patients are often under-evaluated, Hong Kong Medical Journal. 2004, 10: 293-294.

Pei Z. and Cheung R.T.F., Pretreatment with melatonin exerts anti-inflammatory effects against ischemia/reperfusion injury in a rat middle cerebral artery occlusion stroke model, Journal of Pineal Research. 2004, 37: 85-91.

Tsoi T.H. and Cheung R.T.F., Workshop VI: NIHSS training and certification, Hong Kong Stroke Symposium & Workshop 2004. 5: 64-67.

Zou L., Tang F. and Cheung R.T.F., Cerebral ischemia induces neuronal damage in APP/PS1 double transgenic mice via activation of JNK/P38 pathway, Society for Neuroscience 2004. 443.6.

Researcher : Cheung WC

List of Research Outputs

Au W.Y., Cheung W.C. and Tung H.M., Gilbert's syndrome complicating long term parental nutrition, Journal of hepatology.. 2004, 41(1): 168-169.

Researcher : Cheung WMW

Project Title:	Setting up in vitro model systems for studying the functional roles of nuclear receptor PPARgamma during osteoblastogenesis
Investigator(s):	Cheung WMW, Kung AWC
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	09/2004

Abstract:

To identify the correlation between expression level of PPARγ and the stages of osteoblastogenesis; to set up in vitro cell models for studying the functional role(s) of PPARγ during osteoblastogenesis; to identify the effect of PPARγ blockage on the induction of osteoblastogenesis in mesenchymal stem cells.

List of Research Outputs

Kung A.W.C., Lau H.L., Paterson A.D., Cheung W.M.W., Luk K.D.K. and Chan V.N.Y., Test of linkage and/or association of genes and bone mineral density in Chinese, 26th Annual Meeting of the American Society for Bone & Mineral Research, October 1-5, 2004, Seattle, USA. Journal of Bone and Mineral Research. 2004, 19(Supl 1): SU159.

Researcher : Chik SCC

List of Research Outputs

Huang F., Ma L., Wu A.Y.Y., Tian L., Chan K.W., Trendell-Smith N.J., Lam A.C., Chan A.K.L., Lo C.K., Chik S.C.C., Ko K.H., To K.W., Kam S.K., Fong L.P., Li X.S., Leung S.Y., Ng M.H., Stott D.I., Liew F.Y. and MacPherson G.G., Systemic autoimmune disease induced by dendritic cells that have captured necrotic but not apoptotic dying cells, Proceedings of the 12th International Congress of Immunology and the 4th Annual Conference of FOCIS, Montreal, Canada, July 18-23, 2004. 2004.

Researcher : Chim JCS

List of Research Outputs

Au W.Y., Ma S.Y., Chim J.C.S., Choy C., Loong F., Lie A.K.W., Lam C.C.K., Leung A.Y.H., Tse E.W.C., Yau C.C., Liang R.H.S. and Kwong Y.L., Clinicopathologic features and treatment outcome of mature T-cell and natural killer-cell lymphomas diagnosed according to the World Health Organization classification scheme: a single center experience of 10 years, Annals of Oncology. 2005, 16(2): 206-214.

Au W.Y., Chim J.C.S., Lie A.K.W., Leung A.Y.H., Tse E.W.C., Ma S.Y., Liang R.H.S., Pang A.W.K., Kumana C.R. and Kwong Y.L., Treatment of relapsed acute promyelocytic leukemia by arsenic-based strategies without hematopoietic stem cell transplantation in Hong Kong: a seven-year experience, American Society of Haematology Annual Scientific Meeting. 2004.

Chim J.C.S., Wong K.Y., Loong F. and Srivastava G., Absence of ATM hypermethylation in mantle cell and follicular lymphoma, Leukemia. 2005, 19(5): 880-2.

Chim J.C.S., Wong S.S.Y., Lam C.C.K. and Chan K.W., Concurrent hyperreactive malarial splenomegaly and quartan malarial nephropathy – Plasmodium malariae revisited, Haematologica. 2004, 89(7): ECR21.

Chim J.C.S., Ma E.S.K., Loong F. and Kwong Y.L., Diagnostic cues for natural killer cell lymphoma: primary nodal presentation and the role of in situ hybridisation for Epstein-Barr virus encoded early small RNA in detecting occult bone marrow involvement, Journal of clinical pathology. 2005, 58(4): 443-5.

Chim J.C.S. and Ma E.S.K., Eosinophilic leukemic transformation in polycythemia rubra vera (PRV), Leukaemia & Lymphoma. 2005, 46(3): 447-50.

Chim J.C.S., Loong F., Ma E.S.K., Cheung W.W.W., Chim J.C.S. and Ooi C.G.C., Extramedullary cardiac plasmacytoma presenting with cardiac tamponade, Journal of Clinical Oncology. 2005, 23(13): 3140-3.

Chim J.C.S. and Kwong Y.L., How frequent is SOCS1 methylation in acute myeloid leukaemia?, British Journal of Haematology. 2004, 127(5): 609-11.

Chim J.C.S., Ho J.W.C., Ooi C.G.C., Choy C. and Liang R.H.S., Primary anaplastic large cell lymphoma of the pancreas, Leukaemia & Lymphoma. 2005, 46(3): 457-9.

Chim J.C.S., Loong F., Leung A.Y.H., Tsang J. and Ooi C.G.C., Primary follicular lymphoma of the small intestine, Leukaemia & Lymphoma. 2004, 45(7): 1463-6.

Chim J.C.S., Ooi C.G.C., Loong F., Au W.Y., Au W.Y. and Lie A.K.W., Side effects and good effects from new chemotherapeutic agents. Bortezomib in primary refractory plasmacytoma, Journal of Clinical Oncology. 2005, 23(10): 2426-8.

Hui C.K., Bowden S., Jackson K., Au W.Y., Fong D.Y.T., Lie A.K.W., Chim J.C.S., Liang R.H.S. and Lau G., Clinical significance of intrahepatic hepatitis B virus covalently closed circular DNA in chronic hepatitis B patients who received cytotoxic chemotheraphy, Blood. 2005, 105(6): 2616-2617.

Hui C.K., Lie A.K.W., Au W.Y., Ma S.Y., Leung A.Y.H., Zhang H., Sun J.Z., Cheung W.W.W., Chim J.C.S., Kwong Y.L., Liang R.H.S. and Lau G., Effectiveness of prophylactic Anti-HBV therapy in allogeneic hematopoietic stem cell transplantation with HBsAg positive donors, American Journal of Transplantation. 2005, 5(6): 1437-45.

Wong R.W.S., Loong F., Ooi C.G.C., Tse T.C. and Chim J.C.S., Primary granulocytic sarcoma of the mediastinum, Leukaemia & Lymphoma. 2004, 45(9):1931-3.

Researcher : Ching CK

List of Research Outputs

Wong B.C.Y., Chan O.O., Wong K.W., Ching C.K., Wong R.W.M., Tam S., Lai K.C., Chan C.K., Yuen R.M.F. and Lam S.K., A pilot study of participation in faecal occult blood testing and screening colonoscopy after health education in Hong Kong, European Journal of Cancer Preview. 2005, 14(2): 181-184.

Researcher : Chow KM

List of Research Outputs

Ho S.P., Chan M.M.W., Chow K.M., Ip M.S.M. and Mak J.C.W., Antioxidant enzyme activities in healthy Chinese adults: influence of age, gender, and smoking, Respirology. 2005, 10: 305-309.

Wang J., Law K.W., Ip M.S.M., Wu A.Y.Y., Wong M.K., Lam B., Chow K.M. and Chan M.M.W., Effect of asthma self management programme on asthma morbidity and health care utilization in adult patients admitted to hospital with acute asthma in Hong Kong: A randomized controlled trial, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A91.

Researcher : Chow WS

List of Research Outputs

Tan K.C.B., Chow W.S., Lam J.C.M., Lam B., Wong W.K., Tam S. and Ip M.S.M., HDL dysfunction in obstructive sleep apnea, Atherosclerosis. 2005-02-01, 2005, Epub ahead of print.

Tan K.C.B., Xu A., Chow W.S., Ai W.H.G., Tam S. and Lam K.S.L., Hypoadiponectinemia is associated with impaired endothelium-dependent vasodilatation, Journal of Clinical and Endocrinological Metabolism. 2004, 89(2): 765-9.

Xu A., Chan K.W., Wang Y., Zhang J., Hoo R.L.C., Xu J., Chow W.S. and Lam K.S.L., Angiopoietin-like Protein 4 Decreases Blood Glucose and Improves Glucose Tolerance but Induces Hyperlipidemia and Hepatic Steatosis in Mice, Proceedings of the National Academy of Sciences of the United States of America. 2005, 102: 6086-6091.

Xu A., Lam M.C., Chan K.W., Wang Y., Zhang J.C.L., Xu J., Chen B., Chow W.S., Tso A.W. and Lam K.S.L., Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice, Proc Natl Academic Science USA. 2005, 102(17): 6086-91.

Researcher : Choy CBY

List of Research Outputs

Lo W.K., Lui S.L., Chan D.T.M., Li F.K., Lam M.F., Tse K.C., Tang C.S.O., Choy C.B.Y. and Lai K.N., Minimal and optimal peritoneal Kt/V targets: results of an anuric peritoneal dialysis patient's survival analysis. , Kidney International. 2005, 67(5): 2032-2038.

Lui S.L., Tang S., Li F.K., Choy C.B.Y., Chan D.T.M., Lo W.K. and Lai K.N., Tuberculous infection in southern Chinese renal transplant recipients, Clinical transplantation. 2004, 18(6): 666-671.

Researcher : Chu ACY

List of Research Outputs

Ho W.L., Chan Y.L., Kwok H.H., Mak W., Chu A.C.Y., Kung M.H.W., Ramsden D.B. and Ho S.L., mpp+ Modulates Mitochondrial Uncoupling Protein Ucp2, Ucp4 And Ucp5 Expression In Catecholaminergic (sk-n-sh) Cells , J Neurosci Res. 2005, 81(2): 261-8.

Researcher : Chu CYA

List of Research Outputs

Ho W.L., Kwok H.H., Chu C.Y.A., Ho W.M., Kung M.H.W., Ramdsen D.B. and Ho S.L., Silencing of UCP5 enhances MPP+-induced neurotoxicity in SH-SY5Y cells., 9th International Congress of Parkinson’s disease & Movement Disorders, New Orleans, USA. 2005.

Researcher : Chu LW

Project Title:	A dementia outreach programme in Central, Western and Southern districts of Hong Kong
Investigator(s):	Chu LW, Lam KSL, Lee PWH
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	09/2003

Abstract:

To achieve early detection of dementia, through an outreach dementia-screening programme.

List of Research Outputs

Researcher : Chu MY

List of Research Outputs

Chu M.Y., Wong R.W.S., Ho R., Yeung D., Lau S.K., Kwong E. and Lau W.C.S., Utilisation of the Chinese arthritis impact measurement scales-2 (CAIMS-2): capturing clinical status changes in patients with rheumatoid arthritis (RA), 11th APLAR Bi-annual Congress, Jeju, Korea 11-16 September 2004.

Chu M.Y., Chiu P.K.Y., Cheng I., Tang W.M. and Lau W.C.S., Utilisation of the Chinese arthritis impact measurement scales-2 short form (CAIMS-2 SF) in detecting clinical status changes in osteoarthritis (OA) patients who participated in a clinical trial of green-lipped mussel extracts, 11th APLAR Bi-annual Congres, Jeju, Korea 11-16 September 2004.

Lau W.C.S., Chiu P.K.Y., Chu M.Y., Cheng I.Y.W., Tang W.M., Man R.Y.K. and Halpern G.M., Treatment of knee osteoarthritis with Lyprinol, lipid extract of the green-lipped mussel - a double-blind placebo-controlled study, Progress in Nutrition. 2004, 6(1): 17-31.

Researcher : Chuh AAT

List of Research Outputs

Chuh A.A.T. and Chan H.H.L., Effect On Quality Of Life In Patients With Pityriasis Rosea: Is It Associated With Rash Severity?, International Journal Of Dermatology. 2005, 44(5): 372-7.

Chuh A.A.T., Chan H.H.L. and Zawar V., Is Human Herpesvirus 7 The Causative Agent Of Pityriasis Rosea?--a Critical Review, International Journal Of Dermatology. 2004, 43(12): 870-5.

Researcher : Chung SSM

Project Title:	Osmoregulation in lens
Investigator(s):	Chung SSM
Department:	Institute of Molecular Biology
Source(s) of Funding:	Outstanding RGC Projects
Start Date:	09/1998

Abstract:

It is imperative to have a better understanding of the mechanisms leading to various cataracts such that preventive measures can be developed. Since maintaining the ionic strength and ionic composition in the lens is essential for the transparency of the lens, we plan to study the mechanism of osmoregulation in this organ. Transgenic mice that over-express aldose reductase and sodium dependent myoinositol transporter in their lenses will be used to increase the lens' level of sorbitol and myoinositol, respectively. We will determine if high level of these osmolytes causes cataract development, and see when the level of one osmolyte is high, will the lens compensate by reducing the level of other osmolytes. We will also determine whether high intracellular osmotic pressure affects the regulation of expression of genes that control the level of osmolytes such as aldose reductase, sodium dependent myoinositol transporter, and taurine transporter.

Project Title:	Effects of early postnatal feeding on fatty acid metabolism
Investigator(s):	Chung SSM, Sheng HP
Department:	Institute of Molecular Biology
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	11/2002

Abstract:

Both epidemiological studies and animal studies have shown that prenatal and early postnatal nutrition not only affects infant growth and development, it also predetermines future metabolism, performance adn morbidity. This study addresses the problems of nutritional environment during the sucking period on lipid metabolism and later-life obesity.

Project Title:	Mechanism of Nogo-A inhibition of axonal regeneration
Investigator(s):	Chung SSM, Chung SK, Ju G.
Department:	Institute of Molecular Biology
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2003

Abstract:

To develop Nogo gene knockout mice to determine the role of this gene in the inhibition of axonal regeneration and its physiological functions; to develop transgenic mice that overexpress Nogo-A in their Schwann cells to determine if that would make their PNS non-permissive for axonal regeneraton; to develop transgenic mice that overexpress mutant Nogo-A with the Nogo-66 or aa623-640 region deleted to determine which domain is responsible for the inhibitory effect of Nogo-A.

Project Title:	Polyol pathway in diabetic dyslipidemia
Investigator(s):	Chung SSM
Department:	Institute of Molecular Biology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2003

Abstract:

To determine if AR null mutation reduces plasma TG levels in diabetic mice; to determine if ARI reduces plasma TG in diabetic mice; to determine if AR null mutation or ARI nor ARI normalizes LDL and HDL leviabetic mice.

Project Title:	Aldose reductase in diabetic cataract
Investigator(s):	Chung SSM
Department:	Institute of Molecular Biology
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2003

Abstract:

In the slow-developing diabetic cataract, chronic AR-induced oxidative stress impairs the lens' osmoregulatory machinery such that lens can no longer accommodate modest increase in sorbitol, leading to cataract development; We planned to test this model by determing if AR-induced osmotic stress and oxidative stress are both important for the pathogenesis of the slow developing cataract; to determine if osmotic stress and oxidative stress act synergistically to cause cataract development ; to investigate how the impairment in the epithelial cells affects the protein aggregation in the underlying fiber cells to cause lens opacity; to characterize the changes in the epithelial cells during cataract development.

Project Title:	Aldose reductase in diabetic cataract
Investigator(s):	Chung SSM
Department:	Institute of Molecular Biology
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	10/2004

Abstract:

To determine if the antioxidant can prevent AR-induced slow-developing cataract; to determine the osmolyte content and oxidative status of the slow-developing cataract; to compare the morphological changes in the acute diabetic cataract and the slow developing cataract; to determine if there is apoptosis in the epithelial cells of the precataractous lenses.

Project Title:	Aldose reductase in diabetic cataract
Investigator(s):	Chung SSM
Department:	Institute of Molecular Biology
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

Refer to hard copy

List of Research Outputs

Researcher : Cui J

List of Research Outputs

Jiang X., Tu S., Cui J., Lin M.C., Xia H.H.X., Wong R.W.M., Chan O.O., Yuen M.F., Jiang S.H., Lam S.K., Kung H., Soh J.W., Weinstein I.B. and Wong B.C.Y., Antisense Targeting Protein Kinase C Alpha and Beta1 Inhibits Gastric Carcinogenesis, Cancer Research. 2004, 64: 5787-5794.

Tu S., Cui J., Liston P., Jiang X., Xu R., Lin M.C., Zhu Y.B., Zou B., Ng S.M., Jiang S.H., Xia H.H.X., Wong R.W.M., Chan O.O., Yuen R.M.F., Lam S.K., Kung H. and Wong B.C.Y., Gene Therapy for Colon Cancer by Adeno-Associated Viral Vector-Mediated Transfer of Survivin Cys84Ala Mutant, Gastroenterology. 2005, 128: 361-375.

Researcher : Dan Q

List of Research Outputs

Dan Q., Wong L.C., Chung S.K., Chung S.S.M. and Lam K.S.L., Interaction between the polyol pathway and non-enzymatic glycation on aortic smooth muscle cell migration and monocyte adhesion, Life Science. 2004, 76(4): 445-59.

Lam K.S.L., Dan Q., Xu A., Shen J., Cheng K.Y. and Xu J., Adiponectin stimulates the production o fmaganese superoxide dismutase (SOD2) in human aortic smooth muscle cells, 12th International Congress of Endocrinology, Aug 31 – Sep 4, 2004, Lisbon, Portugal. 2004, A442(1242).

Lam K.S.L., Xu A., Tan K.C.B., Wang Y., Dan Q., Chung S.K. and Chung S.S.M., Inflammation and diabetic atherosclerosis: New players in the field, Int Atherosclerosis Society 2005 Commentaries (Epub). 2005.

Xu J., Dan Q., Chan V.N.Y., Wat N.M.S., Tam S., Tiu S.C., Lee K.F., Siu S.C., Tsang M.W., Fung L.M., Chan K.W. and Lam K.S.L., Genetic and Clinical Characteristics of Maturity-onset Diabetes of the Young in Chinese Patients, European Journal of Human Genetics. 2005, 13: 422-427.

Researcher : Deng X

List of Research Outputs

Deng X., Sun H., Lau C.P. and Li G.R., Protein Tyrosine Kinase Modulates Voltage-gated Delayed Rectifier Potassium Channels In Rat Mesenchymal Stem Cells From Bone Marrow, Journal of Hong Kong College Cardiology. 2004, 12: 101(P12).

Li G.R., Sun H., Deng X. and Lau C.P., Characterization of ionic currents in human mesenchymal stem cells from bone marrow, Stem Cells. 2005, 23: 371-382.

Li G.R., Deng X., Sun H. and Lau C.P., Ion Channels And Cell Proliferation In Mesenchymal Stem Cells From Rat Bone Marrow, Biophysical Journal . 2005, 88(2/2): 547a.

Researcher : Ding H

List of Research Outputs

Ding H., Wand B.E., Jia J.D., Xia H.H.X., Wong B.C.Y., Zhao C.H. and Xu Y.L., Effects of octreotide on expression of L-type voltage-operated calcium channels and on intracellular Ca2+ in activated hepatic stellate cells, Chinese Medical Journal. 2004, 117(6): 913-916.

Researcher : Dong M

List of Research Outputs

Dong M., Lau C.P., Gao Z. and Li G.R., Effects Of Protein Tyrosine Kinase Inhibitors On Cloned Human Cardiac IKs Expressed In Hek 293 Cell Line., Journal of Hong Kong College Cardiology. 2004, 12(3/4): 93.

Tian M., Dong M., Chiu S.W., Lau C.P. and Li G.R., Effects Of Clotrimazole On Human Cardiac Repolarization Potassium Currents, Journal of Hong Kong College Cardiology. 2004, 12(3/4): 101(P11).

Wang Y., Dong M., Lau C.P. and Li G.R., Modulation of human Ehter-a-go-go-related potassium (hERG) channels by protein tyrosine kinases, Journal of Hong Kong College Cardiology. 2004, 12(3/4): 102(P15).

Researcher : Epstein R

Project Title:	Evolutionarily conserved patterns of synonymous codon bias in wild-type orthologous and paralogous gene sequences, and comparison with patterns of bias in human tumour genomes
Investigator(s):	Epstein R
Department:	Medicine
Source(s) of Funding:	Seed Funding for New Staff
Start Date:	09/2003

Abstract:

To clarify whether these evident associations of synonymous codon bias with function and/or with methylation are interdependent or independent.

Project Title:	The contribution of receptor downregulation to the efficacy of anticancer drugs targeting the catalytic activity of ErbB-family oncoproteins
Investigator(s):	Epstein R
Department:	Medicine
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2004

Abstract:

Refer to hard copy

List of Research Outputs

Cheung Y.B., Wong L.C., Tay M.H., Toh C.K., Koo W.H., Epstein R. and Goh C., Order effects in the assessment of quality of life in cancer patients, Quality of Life Research. 2004, 13(7): 1217-23.

Epstein R., Journal impact factors do not equitably reflect academic staff performance in different medical subspecialties, Journal of investigative medicine. 2004, 52(8): 531-6.

Epstein R., The CXCL12-CXCR4 chemotactic pathway as a target of adjuvant breast cancer therapies, Nature Reviews Cancer. 2004, 4 (11): 901-909.

Tsang J.W., Leung A.W., Yau T.C., Liang R.H.S., Yeung D.W., Leung T.W.T., Teo P.M., Cheung P.S. and Epstein R., Multidisciplinary management of early-stage breast cancer in the Asia-Pacific region, Medical Progress. 2004, 31: 485-96.

Researcher : Feng Z

List of Research Outputs

Li G., Xia H.H.X., Chen M.H., Chan O.O., Cho C.H., Lam S.K., Berg D., Feng Z., Langenbach R. and Wong B.C.Y., Effects of Cyclooxygenase-1 and -2 Gene Disruption on Helicobacter pylori-Induced Inflammation, Apoptosis and Proliferation, Journal of Gastroenterology and Hepatology. 2004, 19(Suppl.): A299.

Xia H.H.X., Li G., Chen M.H., Chan O.O., Cho C.H., Lam S.K., Berg D., Feng Z., Langenbach R. and Wong B.C.Y., Cyclooxygenase-1 and -2 Gene Disruption Potentiate TH1 Polarization in Response to Helicobacter pylori, Journal of Gastroenterology and Hepatology. 2004, 19(Suppl.): A366.

Researcher : Fong CY

List of Research Outputs

Chan K.H., Cheung R.T.F., Mak W., Lee R., Fong C.Y., Cheng T.S. and Ho S.L., Cerebral infarction complicating tuberculous meningitis (TBM), 17th Annual Scientific Meeting, The Hong Kong Neurological Society. 2004, 10: 8.

Chan K.H., Tsang K.L., Fong C.Y., Cheung R.T.F. and Ho S.L., Idiopathic severe recurrent transverse myelitis: a restricted variant of neuromyelitis optica, Clinical Neurology and Neurosurgery. 2005, 107: 132-135.

Lui C.H.T., Fong C.Y., Kwan P., Hui A.C.F., Fong K.Y. and Wong V.C.N., A Population-Based Epidemiological Study of Epilepsy in Hong Kong, 5th Asian & Oceanian Epilepsy Congress, Bangkok, Thailand, 28-31 August 2004. 23.

Researcher : Fong HY

List of Research Outputs

Tso A.W.K., Wat N.M.S., Xu A., Sham P.C., Rong R., Cheng K.Y., Fong H.Y., Janus E.D. and Lam K.S.L., The adiponectin gene G276T polymorphism is a risk factor for the development of the metabolic syndrome over a period of 5 years in southern Chinese, 12th International Congress of Endocrinology, Aug 31 – Sep 4, 2004, Lisbon, Portugal. 2004, 318 P949.

Wat N.M.S., Tso A.W.K., Xu A., Sham P.C., Rong R., Cheng K.Y., Fong H.Y., Janus E.D. and Lam K.S.L., The adiponectin gene T45G polymorphism is associated with central obesity and persistent glucose intolerance in high-risk Chinese subjects over 5 years, 12th International Congress of Endocrinology, Aug 31 – Sep 4, 2004, Lisbon, Portugal. 2004.

Researcher : Fong KY

List of Research Outputs

Lui C.H.T., Fong C.Y., Kwan P., Hui A.C.F., Fong K.Y. and Wong V.C.N., A Population-Based Epidemiological Study of Epilepsy in Hong Kong, 5th Asian & Oceanian Epilepsy Congress, Bangkok, Thailand, 28-31 August 2004. 23.

Researcher : Fung FMY

List of Research Outputs

Wong R.W.M., Huang J., Xia H.H.X., Fung F.M.Y., Tong S.M., Cheung K.L., Ho Y.K., Lai K.C., Chan C.K., Chan O.O., Hui C.K., Lam S.K. and Wong B.C.Y., Low-dose rabeprazole, amoxicillin and metronidazole triple therapy for the treatment of Helicobacter pylori infection in Chinese patients , Journal of Gastroenterology and Hepatology. 2005, 20(6): 935-940.

Researcher : Fung PCW

Project Title:	Development of a novel natural antioxidant with strong anti-aging and protective properties for skin
Investigator(s):	Fung PCW, Shen J
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	07/2002

Abstract:

To develop a novel antioxidants from herbal products which can scavenge superoxide, hydroxyl and lipid peroxide free radicals in skin.

Project Title:	Roles of plasma membrane cholesterol homeostasis in regulating neuronal oxidative damage of ischemic stroke
Investigator(s):	Fung PCW, Shen J
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Abstract:

To understand the roles of plasma membrane cholesterol homeostasis in protecting neuronal cells from oxidative damage during ischemic stroke.

List of Research Outputs

Chang C., Ren J., Fung P.C.W., Hung Y.S., Shen J.G. and Chan F.H.Y., Novel sparse component analysis approach to free radical EPR spectra decomposition, Journal of Magnetic Resonance. 2005, 175: 242-255.

Chen J.H., Tipoe G.L., Liong E.C., So H.S.H., Leung K.M., Tom W.M., Fung P.C.W. and Nanji A.A., Green tea polyphenols prevent toxin-induced hepatotoxicity in mice by down-regulating inducible nitric oxide-derived prooxidants, American Journal of Clinical Nutrition. 2004, 80: 742-751.

Ho K.M.T., Li A.Z., Yiu M.K., Lee K.C., Lui V.C.H., Fung P.C.W., Yiu T.F. and Tam P.K.H., Altered expression of aquaporin-2 in human explants with chronic renal allograft dysfunction, BJU International. 2005, 95: 1104-1108.

Man K., Lee K.W., Liang T.B., Lo C.M., Fung P.C.W., Tsui H.T., Li X.L., Ng T.P. and Fan S.T., FK409 ameliorates small-for-size liver graft injury by attenuation of portal hypertension and down-regulation of Egr-1 pathway, Annals of Surgery. 2004, 240(1): 159-168.

Ren J., Shen J., Xhan F. .H., Shen G.G. and Fung P.C.W., Real time detectionn of nitric oxide in the blood of rats following renal ischemia by ESR spectroscopy, 13th Annual Meeting of ISMRM, Miami, Florida. San Francesco, USA, ISMRM, 2005, 1: 2555.

Sun X., Krissansen G.W., Fung P.C.W., Xu S., Shi J., Man K., Fan S.T. and Xu R., Anti-angiogenic therapy subsequent to adeno-associated-virus-mediated immunotherapy eradicates lymphomas that disseminate to the liver, International Journal of Cancer. 2004, 113(4): 670-677.

Tang M., Chang C., Fung P.C.W., Chau K.T. and Chan F.H.Y., An effective way of distinguishing premature ventricular contraction from sinus based on analysis of chaotic feature, IEE Advances in Medical Signal and Information Processing Conference. Malta, 2004, 85-91.

Researcher : Gao Z

List of Research Outputs

Dong M., Lau C.P., Gao Z. and Li G.R., Effects Of Protein Tyrosine Kinase Inhibitors On Cloned Human Cardiac IKs Expressed In Hek 293 Cell Line., Journal of Hong Kong College Cardiology. 2004, 12(3/4): 93.

Gao Z., Sun H., Chiu S.W., Lau C.P. and Li G.R., Effects Of Diltiazem And Nifedipine On Transient Outward And Ultra-rapid Delayed Rectifier Potassium Currents In Human Atrial Myocytes, Br J Pharmacol. 2005, 144: 495-604.

Researcher : Gisselsson DL

List of Research Outputs

Gisselsson D.L., Lu M., Tsao G.S.W., Man C.W.Y., Jin C., Jin C., HOglund M., Kwong Y.L. and Jin Y., Telomere-mediated mitotic disturbances in immortalized ovarian epithelial cells reproduce chromosomal losses and breakpoints from ovarian carcinoma, Genes, Chromosomes and Cancer. 2004, 42(1): 22-23.

Researcher : Gu J

List of Research Outputs

Gu J., Lee K.K., Kwan E.Y.W., Lam K.F., Ho A.Y.Y., Tam S. and Kung A.W.C., Determinants of bone mineral density in Asian men, 26th Annual Meeting of the American Society for Bone & Mineral Research, October 1-5, 2004, Seattle, USA. Journal of Bone and Mineral Research. 2004, 19(Supl 1): SU115.

Gu J., Lee K.K., Cheung E.Y.N., Lam K.F., Ho A.Y.Y., Tam S. and Kung A.W.C., Determinants of bone mineral density in Asian men, HKU 10th Medical Research Conference. 2005.

Gu J., Chan V.N.Y. and Kung A.W.C., Determinants of bone mineral density in early postmenopausal Asian women: The significance of family history of fracture, 6th Regional Osteoporosis Conference, 21-22 May 2005, Hong Kong. 2005.

Researcher : Gu Q

List of Research Outputs

Gu Q., Wang J., Xia H.H.X., Lin M.C., He H., Zou B., Tu S., Yang Y., Liu X.G., Lam S.K., Wong R.W.M., Chan O.O., Yuen R.M.F., Kung H. and Wong B.C.Y., Activation of the Caspase-8/Bid and Bax Pathways in Aspirin-Induced Apoptosis in Gastric Cancer, Carcinogenesis. 2005, 26(3): 541-546.

Gu Q., Xia H.H.X., Wang W., Wang J., Wong R.W.M., Chan O.O., Yuen M.F., Lam S.K., Cheung K.L., Liu X.G. and Wong B.C.Y., Effect of Cyclo-Oxygenase Inhibitors on Helicobacter pylori Susceptibility to Metronidazole and Clarithromycin, Alimentary Pharmacology and Therapeutics. 2004, 20: 675-681.

Wang J., Zou B., Gu Q., Jiang B., Zhuang Z., Xia H.H.X., Lin M.C., Lam S.K., Kung H. and Wong B.C.Y., Down-regulation of XAF1 expression by its interacting protein FHL2 via p53-mediated transcription regulation, Gastroenterology. 2005, 128(4 Suppl 2): A105.

Wang J., Gu Q., He H., Jiang B., Zhuang Z., Xia H.H.X., Lin M.C., Lam S.K., Kung H. and Wong B.C.Y., Down-regulation of XIAP associated factor 1 (XAF1) through Hsf-1 binding in the promoter region, Gastroenterology. 2005, 128(4 Suppl 2): A105.

Wong R.W.M., Xiao S.D., HU P.J., Wang W., Gu Q., Huang J., Xia H.H.X., WU S.M., LI C.J., CHEN M.H., CUI Y., Lai K.C., Hu H.C., Chan C.K., Lam S.K. and Wong B.C.Y., Standard treatment for Helicobacter pylori infection is suboptimal in non-ulcer dyspepsia compared to duodenal ulcer in Chinese, Alimentary Pharmacology and Therapeutics. 2005, 21: 73-81.

Researcher : Gu Q

List of Research Outputs

Researcher : Guo H

List of Research Outputs

Leung J.C.K., Chan L.Y., Tsang W.L., Guo H., Tang S.C.W., Chan D.T.M. and Lai K.N., Differential expression of aquaporins in the kidneys of streptozotocin-induced diabetic mice , Nephrology. 2005, 10: 63-72.

Researcher : He H

List of Research Outputs

Gu Q., Wang J., Xia H.H.X., Lin M.C., He H., Zou B., Tu S., Yang Y., Liu X.G., Lam S.K., Wong R.W.M., Chan O.O., Yuen R.M.F., Kung H. and Wong B.C.Y., Activation of the Caspase-8/Bid and Bax Pathways in Aspirin-Induced Apoptosis in Gastric Cancer, Carcinogenesis. 2005, 26(3): 541-546.

He H., Anti-Tumor Mechanisms of Cyclooxygenase Inhibitors and a c-Jun-N-Terminal Kinase Inhibitor in Gastrointestinal Cancers, 2004.

Wang J., Gu Q., He H., Jiang B., Zhuang Z., Xia H.H.X., Lin M.C., Lam S.K., Kung H. and Wong B.C.Y., Down-regulation of XIAP associated factor 1 (XAF1) through Hsf-1 binding in the promoter region, Gastroenterology. 2005, 128(4 Suppl 2): A105.

Zhuang Z., Tsao G.S.W., Xia H.H.X., He H., Chan O.O., Lam S.K. and Wong B.C.Y., COX-2 inhibition induces apoptosis in human esophageal epithelial cells: implication for chemoprevention, Gastroenterology. 2005, 128(4 Suppl 2): A299.

Researcher : He H

List of Research Outputs

He H., Anti-Tumor Mechanisms of Cyclooxygenase Inhibitors and a c-Jun-N-Terminal Kinase Inhibitor in Gastrointestinal Cancers, 2004.

Researcher : Ho JCM

List of Research Outputs

Chan M.M.W., Tan-Un K.C., Ip M.S.M., Tsang K.W.T., Ho S.P., Ho J.C.M., Chan H. and Lam W.K., Lung Cancer Susceptibility and Polymorphism of Glutathione-S-transferase Genes in Hong Kong, Lung Cancer. 2004, 45(2): 155-160.

Chan M.M.W., Lam W.K., Mak J.C.W., Ho S.P., Chan H.W., Tsang K.W.T., Ip M.S.M., Ho J.C.M., Wong M.P. and Tan-Un K., Polymorphisms of CYP and GST genes, passive smoke and lung cancer risk in Hong Kong Chinese, European Respiratory Journal. 2004, 24: Suppl 48: 457s.

Ho J.C.M., Community Acquired Pneumonia in the Post SARS Era , 9th Hong Kong Medical Forum. 2004.

Ho J.C.M., Lam W.K., Wong M.P., Wong M.K., Ooi C.G.C., Ip M.S.M., Chan M.M.W. and Tsang K.W.T., Lymphoepithelioma-like carcinoma of the lung : experience with ten cases, International Journal of Tuberculosis and Lung Disease. 2004, 8(7): 890-895.

Ho J.C.M., Mak J.C.W., Ho S.P., Ip M.S.M., Tsang K.W.T., Lam W.K. and Chan M.M.W., Manganese superoxide dismutase and catalase genetic polymorphisms activity levels and lung cancer risk in Chinese in Hong Kong, 10th Medical Research Conference, Department of Medicine, The University of Hong Kong, February 2005. Abstract Book: RM 66.

Ho J.C.M., Ho S.P., Chan M.M.W., Mak J.C.W., Ip M.S.M., Ko K.W., Yan C.P.K., Wong M.P., Tsang K.W.T. and Lam W.K., Non-small cell lung cancer in Chinese is associated with disturbance in systemic antioxidant profiles, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December, 2004. Respirology. 2004, 9 (Supp): A114.

Ho J.C.M., Wu A.Y.Y., Lam B., Ooi C.G.C., Khong P.L., Ho P.L., Chan M.M.W., Zhong N.S., Ko K.W., Lam W.K. and Tsang K.W.T., Pentaglobin in steroid-resistant severe acute respiratory syndrome, International Journal of Tuberculosis and Lung Disease. 2004, 8(10): 1173-1179.

Kwok P.W., Leung Y.H., Sun J.Z., Yan C.P.K., Ooi C.G.C., Ho P.L., Ho J.C.M., Tipoe G.L., Lam W.K. and Tsang K.W.T., The Effects of Gelomyrtol Forte on Human Ciliary Beat Frequency in vitro, Abstract Book of the 10th Medical Research Conference, University Department of Medicine, The University of Hong Kong, 19-20 February. 2005, page 65.

Kwok R., Leung Y.H., Sun J.Z., Yan C.P.K., Ooi C.G.C., Ho P.L., Ho J.C.M., Tipoe G.L., Lam W.K. and Tsang K.W.T., The effects of gelomyrtol forte on human ciliary beat frequency in vitro, Respirology. 2004, 9 (Suppl): A162 (290).

Lam W.K., Ho J.C.M., Lam B. and Tsang K.W.T., SARS and impacts on travel, Textbook of Travel Medicine . Bangkok Press, Bangkok, 2004, Chapter 38: 405-414.

Mak J.C.W., Ho J.C.M., Ho S.P., Yu W.C., Yew W.W., Tsang K.W.T., Lam W.K., Ip M.S.M. and Chan M.M.W., Increased oxidative stress and altered antioxidant status in Chinese patients with COPD, European Respiratory Journal. 2004, 24: Suppl 48: 62s.

Mak J.C.W., Ho J.C.M., Ho S.P., Leung C.M., Law K.W., Ip M.S.M. and Chan M.M.W., Polymorphisms of superoxide dismutase and catalase genes and their functional activity levels in Chinese patients with asthma, American Thoracic Society International Conference, San Diego, USA. May 2005. Proceedings of the American Thoracic Society . 2005, p.A78.

Pang C., Fan S., Yiu M.W.C., Tsang K.W.T., Ho J.C.M. and Ooi C.G.C., Clinical utility of multislice CT in the investigation of haemoptysis., 1st World Congress of Thoracic Imaging, Florence, Italy.. 2005.

Tsang K.W.T., Tipoe G.L., Mak J.C.W., Sun J.Z., Wong M.P., Leung R.C.M., Tan K.C.B., MedStat C.K.M., Ho J.C.M., Ho P.L., Rutman A. and Lam W.K., Ciliary central microtubular orientation is of no clinical significance in bronchiectasis, Respiratory Medicine. 2005, 99: 290-297.

Tsang K.W.T., Tipoe G.L., Sun J.Z., Tan K.C.B., Leung Y.H., Yan C.P.K., Ko K.W., Ooi C.G.C., Ho J.C.M. and Lam W.K., Clinical value of ciliary assessment in bronchiectasis, Lung. 2005, 183(2): 73-86.

Researcher : Ho SKN

List of Research Outputs

Chan D.T.M., Tse K.C., Tang C.S.O., Lai K.N. and Ho S.K.N., Prospective study on lamivudine-resistant hepatitis B in renal allograft recipients, American Journal of Transplantation. 2004, 4(7): 1103-1109.

Researcher : Ho SL

Project Title:	Search for a new gene in familial amyotrophic lateral sclerosis
Investigator(s):	Ho SL, Fong CY, Ramsden D.B.
Department:	Medicine
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2003

Abstract:

To carry out more detailed genetic screening of family members and appropriate controls to elucidate whether the theoretical gene and/or any other within this region of the chromosome is associated with the disease; to elucidate expression of this novel protein in healthy human subjects; to investigate whether genetic mutation/s in this gene may be the causal defects in sporadic ALS, which form the large majority of case and for which there is no known cause.

List of Research Outputs

Au W.Y., Mak W., Ho S.L., Leung S.Y. and Kwong Y.L., Reversible paraneoplastic neuropathy associated with T-cell large granular lymphocyte leukemia, Neurology. 2004, 63(3): 588-589.

Cartwright L., Ramsden D.B., Smith S.W., Parsons R.B., Waring R.H., Ho S.L. and Williams A.C., Xenobiotic metabolism and idiopathic Parkinson’s disease. In: Parkinson's Disease (M Ebadi, RF Pfeiffer, Eds), New York, CRC Press Ltd, 2005, 97- 108.

Chan K.H., Cheung R.T.F., Au Yeung K.M., Mak W., Cheng T.S. and Ho S.L., A lady with suicidal history presented with speech and walking difficulties, Journal of Clinical Neuroscience. 2005, 12: 303-305.

Chan K.H., Cheung R.T.F., Mak W., Lee R., Fong C.Y., Cheng T.S. and Ho S.L., Cerebral infarction complicating tuberculous meningitis (TBM), 17th Annual Scientific Meeting, The Hong Kong Neurological Society. 2004, 10: 8.

Chan K.H., Cheung R.T.F., Lee R., Mak W., Cheng T.S. and Ho S.L., Cerebral infarcts complicating tuberculous meningitis, Cerebrovascular Diseases. 2005, 19: 391-395.

Chan K.H., Cheung R.T.F., Lui W.M., Mak W. and Ho S.L., Cerebral venous thrombosis in a gentleman with fever, convulsion and frontotemporal haemorrhages, Journal of Clinical Neuroscience. 2005, 12: 186-188.

Chan K.H., Tsang K.L., Fong C.Y., Cheung R.T.F. and Ho S.L., Idiopathic severe recurrent transverse myelitis: a restricted variant of neuromyelitis optica, Clinical Neurology and Neurosurgery. 2005, 107: 132-135.

Chan K.H., Mak W., Cheng T.S., Cheung R.T.F. and Ho S.L., Natural course of patients with acute myelitis, 17th Annual Scientific Meeting, The Hong Kong Neurological Society. 2004, 10: 6.

Chan K.H., Cheung R.T.F., AuYeung K.M., Mak W. and Ho S.L., Wilson's Disease With Depression And Parkinsonism., J Clin Neurosci. 2005, 12(3): 303-5.

Ho W.L., Chan Y.L., Kwok H.H., Mak W., Chu A.C.Y., Kung M.H.W., Ramsden D.B. and Ho S.L., mpp+ Modulates Mitochondrial Uncoupling Protein Ucp2, Ucp4 And Ucp5 Expression In Catecholaminergic (sk-n-sh) Cells , J Neurosci Res. 2005, 81(2): 261-8.

Ho W.L., Chan Y.L., Leung K.C., Kung M.H.W., Ramsden D.B. and Ho S.L., Potential Role Of Uncoupling Proteins, Ucp2, -4, And -5, In The Neuroprotective Effects Of Estrogen On Mpp+-induced Neurotoxicity. , 8th International Congress of Parkinson's disease & Movement Disorders, Rome, Italy. 2004.

Ho W.L., Kwok H.H., Chu C.Y.A., Ho W.M., Kung M.H.W., Ramdsen D.B. and Ho S.L., Silencing of UCP5 enhances MPP+-induced neurotoxicity in SH-SY5Y cells., 9th International Congress of Parkinson’s disease & Movement Disorders, New Orleans, USA. 2005.

Hon C., Ho S.L., Ma E.S.K., Trendell-Smith N.J. and Au W.Y., High-grade lymphoma after azathioprine treatment for Vogt-Kaganayi-Harada syndrome, Leukemia & Lymphoma . 2005, 46: 289-292.

Lee T.M.C., Chan C.C.H., Ho S.L. and Li L.S.W., Prose memory in patients with idiopathic Parkinson’s disease. , Parkinsonism and Related Disorders . 2005, 11: 453-458.

Mak W., Chan K.H. and Ho S.L., A Case Of Ocular Myasthenia Gravis And Miller Fisher Syndrome, Hospital Medicine. 2005, 66(2): 116-7.

Mak W., Tsang K.L., Tsoi T.H., AuYeung K.M.A., Chan K.H., Cheng T.S., Cheung R.T.F. and Ho S.L., Bath-related Headache, Cephalalgia. 2005, 25(3): 191-8.

Mak W., Chan K.H., Cheung R.T.F. and Ho S.L., Hypertensive encephalopathy: BP lowering complicated by posterior circulation ischemic stroke, Neurology. 2004, 63: 1131-1132.

Mak W., Cheung R.T.F. and Ho S.L., Racial/ethnic differences in cerebrovascular disease – HK perspective, Hong Kong Stroke Symposium & Workshop 2004. 5: 42-46.

Mak W., Cheung R.T.F. and Ho S.L., Riches-Cannieu anastomosis: an electrophysiology study in Hong Kong Chinese and its implications in carpal tunnel syndrome, 17th Annual Scientific Meeting, The Hong Kong Neurological Society. 2004, 10: 11.

Mak W., Cheung R.T.F. and Ho S.L., Why is intracranial large-artery steno-occlusive disease more common in Asians? A human evolutionary hypothesis and its implications, 17th Annual Scientific Meeting, The Hong Kong Neurological Society. 2004, 10: 29.

Mak W., Tsang K.L., Tsoi T.H., Au Yeung K.M., Chan K.H., Cheng T.S., Cheung R.T.F. and Ho S.L., “Thundery Shower”: a novel headache syndrome, 17th Annual Scientific Meeting, The Hong Kong Neurological Society. 2004, 10: 30.

Researcher : Ho SP

List of Research Outputs

Chan M.M.W., Tan-Un K.C., Ip M.S.M., Tsang K.W.T., Ho S.P., Ho J.C.M., Chan H. and Lam W.K., Lung Cancer Susceptibility and Polymorphism of Glutathione-S-transferase Genes in Hong Kong, Lung Cancer. 2004, 45(2): 155-160.

Chan M.M.W., Lam W.K., Mak J.C.W., Ho S.P., Chan H.W., Tsang K.W.T., Ip M.S.M., Ho J.C.M., Wong M.P. and Tan-Un K., Polymorphisms of CYP and GST genes, passive smoke and lung cancer risk in Hong Kong Chinese, European Respiratory Journal. 2004, 24: Suppl 48: 457s.

Ho J.C.M., Mak J.C.W., Ho S.P., Ip M.S.M., Tsang K.W.T., Lam W.K. and Chan M.M.W., Manganese superoxide dismutase and catalase genetic polymorphisms activity levels and lung cancer risk in Chinese in Hong Kong, 10th Medical Research Conference, Department of Medicine, The University of Hong Kong, February 2005. Abstract Book: RM 66.

Ho J.C.M., Ho S.P., Chan M.M.W., Mak J.C.W., Ip M.S.M., Ko K.W., Yan C.P.K., Wong M.P., Tsang K.W.T. and Lam W.K., Non-small cell lung cancer in Chinese is associated with disturbance in systemic antioxidant profiles, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December, 2004. Respirology. 2004, 9 (Supp): A114.

Ho S.P., Chan M.M.W., Chow K.M., Ip M.S.M. and Mak J.C.W., Antioxidant enzyme activities in healthy Chinese adults: influence of age, gender, and smoking, Respirology. 2005, 10: 305-309.

Ho S.P., Chan M.M.W., Wong M.P., Tsang K.W.T., Ip M.S.M., Lam W.K. and Mak J.C.W., Transforming growth factor (TGF)-beta 1 gene common polymorphisms and plasma TGF-beta 1 levels in patients with lung cancer, 10th Medical Research Conference, Department of Medicine, The University of Hong Kong, February 2005. Abstract Book: RM 60.

Ho S.P., Chan M.M.W., Tsang K.W.T., Ip M.S.M., Lam W.K. and Mak J.C.W., Transforming growth factor (TGF)-beta 1 gene common polymorphisms and plasma TGF-beta 1 levels in patients with lung cancer, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A120.

Mak J.C.W., Ho S.P., Leung Y.H., Ho P.L., Ooi C.G.C., Yan C.P.K., Ko K.W., Ip M.S.M., Lam W.K. and Tsang K.W.T., Elevated levels of transforming growth factor- beta 1 in serum of patients with stable bronchiectasis, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A134.

Mak J.C.W., Leung C.M., Ho S.P., Law K.W., Tsang K.W.T., Lam W.K., Ip M.S.M. and Chan M.M.W., Genetic susceptibility of transforming growth factor beta-1 common polymorphisms to Chinese patients with asthma, American Thoracic Society International Conference, San Diego, USA. May 2005. Proceedings of the American Thoracic Society. 2005, p.A78.

Mak J.C.W., Ho J.C.M., Ho S.P., Yu W.C., Yew W.W., Tsang K.W.T., Lam W.K., Ip M.S.M. and Chan M.M.W., Increased oxidative stress and altered antioxidant status in Chinese patients with COPD, European Respiratory Journal. 2004, 24: Suppl 48: 62s.

Mak J.C.W., Ho J.C.M., Ho S.P., Leung C.M., Law K.W., Ip M.S.M. and Chan M.M.W., Polymorphisms of superoxide dismutase and catalase genes and their functional activity levels in Chinese patients with asthma, American Thoracic Society International Conference, San Diego, USA. May 2005. Proceedings of the American Thoracic Society . 2005, p.A78.

Mak J.C.W., Leung H.C., Ho S.P., Lam W.K., Tsang K.W.T., Ip M.S.M. and Chan M.M.W., Systemic antioxidant status in Chinese patients with asthma, European Respiratory Journal. 2004, 24: Suppl 48: 509s.

Mak J.C.W., Leung C.M., Ho S.P., Lam W.K., Tsang K.W.T., Ip M.S.M. and Chan M.M.W., Systemic oxidative and antioxidative status in Chinese patients with asthma, Journal of Allergy and Clinical Immunology. 2004, 114(2): 260-264.

Researcher : Ho WL

List of Research Outputs

Ho W.L., Chan Y.L., Kwok H.H., Mak W., Chu A.C.Y., Kung M.H.W., Ramsden D.B. and Ho S.L., mpp+ Modulates Mitochondrial Uncoupling Protein Ucp2, Ucp4 And Ucp5 Expression In Catecholaminergic (sk-n-sh) Cells , J Neurosci Res. 2005, 81(2): 261-8.

Ho W.L., Chan Y.L., Leung K.C., Kung M.H.W., Ramsden D.B. and Ho S.L., Potential Role Of Uncoupling Proteins, Ucp2, -4, And -5, In The Neuroprotective Effects Of Estrogen On Mpp+-induced Neurotoxicity. , 8th International Congress of Parkinson's disease & Movement Disorders, Rome, Italy. 2004.

Ho W.L., Kwok H.H., Chu C.Y.A., Ho W.M., Kung M.H.W., Ramdsen D.B. and Ho S.L., Silencing of UCP5 enhances MPP+-induced neurotoxicity in SH-SY5Y cells., 9th International Congress of Parkinson’s disease & Movement Disorders, New Orleans, USA. 2005.

Researcher : Ho WL

List of Research Outputs

Researcher : Ho WM

List of Research Outputs

Ho W.L., Kwok H.H., Chu C.Y.A., Ho W.M., Kung M.H.W., Ramdsen D.B. and Ho S.L., Silencing of UCP5 enhances MPP+-induced neurotoxicity in SH-SY5Y cells., 9th International Congress of Parkinson’s disease & Movement Disorders, New Orleans, USA. 2005.

Researcher : Ho YK

List of Research Outputs

Wong R.W.M., Huang J., Xia H.H.X., Fung F.M.Y., Tong S.M., Cheung K.L., Ho Y.K., Lai K.C., Chan C.K., Chan O.O., Hui C.K., Lam S.K. and Wong B.C.Y., Low-dose rabeprazole, amoxicillin and metronidazole triple therapy for the treatment of Helicobacter pylori infection in Chinese patients , Journal of Gastroenterology and Hepatology. 2005, 20(6): 935-940.

Researcher : Hoo RLC

List of Research Outputs

Chan K.W., Xu A., Hoo R.L.C., Tan K.C.B., Zhang J., Lam C.W. and Lam K.S.L., Selective Reduction of the High Molecular Weight Form of Adiponectin by Testosterone: A Potential Mechanism That Underlies the Sexual Dimorphism of Adiponectin Oligomeric Distribution, The Endocrine Society’s 87th Annual Meeting, June 4-7, 2005, San Diego, USA. 2005.

Chan K.W., Xu A., Hoo R.L.C., Lam C.W. and Lam K.S.L., Sexual dimorphism of adiponectin: Why do men have higher risk to diabetes and atherosclerosis than women?, 10th Medical Research Conference, The University of Hong Kong. 19-20 Feb 2005. Endocrinology 24.

Chen B., Xu A., Lam C.W., Hoo R.L.C. and Lam K.S.L., Adenovirus-mediated expression of adiponectin alleviates liver fibrosis and induces apoptosis of activated hepatic stellate cells, 10th Medical Research Conference, The University of Hong Kong. 19-20 Feb 2005. Endocrinology 23.

Hoo R.L.C., Xu A., Lam C.W., Chen B., Carling D. and Lam K.S.L., Adenovirus-mediated expression of constitutively active AMP-activated protein kinase alleviates diabetes in db/db diabetic mice, 10th Medical Research Conference, The University of Hong Kong. 19-20 Feb 2005. Endocrinology 25.

Xu A., Hoo R.L.C., Hoo R.L.C., Lam C.W., Chen B. and Lam K.S.L., Adenovirus-Mediated Expression of Adiponectin Alleviates Endothelial Dysfunction and Oxidative Stress Associated with db/db Diabetic Mice, The Endocrine Society’s 87th Annual Meeting, June 4-7, 2005, San Diego, USA. 2005.

Xu A., Chan K.W., Wang Y., Zhang J., Hoo R.L.C., Xu J., Chow W.S. and Lam K.S.L., Angiopoietin-like Protein 4 Decreases Blood Glucose and Improves Glucose Tolerance but Induces Hyperlipidemia and Hepatic Steatosis in Mice, Proceedings of the National Academy of Sciences of the United States of America. 2005, 102: 6086-6091.

Xu A., Lam C.W., Chan K.W., Zhang J., Hoo R.L.C., Xu J., Chen B. and Lam K.S.L., Angiopoietin-like protein 4 is a novel metabolic hormone with therapeutic potentials for hyperglycemia and insulin resistance, 10th Medical Research Conference, The University of Hong Kong. 19-20 Feb 2005. Endocrinology 22.

Xu A., Chan K.W., Hoo R.L.C., Wang Y., Zhang J., Chen B., Cynthia T., Cooper G.J.S. and Lam K.S.L., Testosterone Selectively Reduces the High Molecular Weight Form of Adiponectin by Inhibiting Its Secretion from Adipocytes, The Journal of Biological Chemistry. 2005, 280: 18073-18080.

Xu A., Chan K.W., Hoo R.L.C., Wang Y., Tan K.C.B., Zhang J.C.L., Chen B., Lam M.C., Tse C., Cooper G.J. and Lam K.S.L., Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes, J Biol Chem. 2005, 280(18): 18073-80.

Researcher : Hu HC

Project Title:	A study to validate a symptom severity questionnaire for patents with functional dyspepsia
Investigator(s):	Hu HC, Lam CLK
Department:	Medicine
Source(s) of Funding:	Health Services Research Fund - Full Grants
Start Date:	10/1998

Abstract:

To develop and validate an instrument to measure the severity of symptoms in patients with functional dyspepsia.

List of Research Outputs

Hui C.K., Lai K.C., Wong R.W.M., Yuen R.M.F., Ng M.M.T., Chan C.K., Hu H.C., Cheung W.W., Lai C.L. and Wong B.C.Y., Outpatients Undergoing Therapeutic Endoscopic Retrograde Cholangiopancreatography: Six-hour Versus Overnight Observation , Journal of Gastroenterology and Hepatology. 2004, 19: 1163-1168.

Lai K.C., Hui W.M., Wong B.C.Y., Hu H.C., Chan O.O. and Lam S.K., Lansorprazole but not Rofecoxib reduced dyspeptic symptoms of patients on NSAIDS, Gastroenterology. 2005, 128(4 Suppl 2): A24.

Wong R.W.M., Lai K.C., Hui W.M., Hu H.C., Huang J., Wong Y.H., Xia H.H.X., Chan O.O., Lam S.K. and Wong B.C.Y., Pathophysiology of Gastroesophageal Reflux Diseases in ChineseRole of Transient Lower Esophageal Sphincter Relaxation and Esophageal Motor Dysfunction, American Journal of Gastroenterology. 2004, 99: 2088-2093.

Wong R.W.M., Xiao S.D., HU P.J., Wang W., Gu Q., Huang J., Xia H.H.X., WU S.M., LI C.J., CHEN M.H., CUI Y., Lai K.C., Hu H.C., Chan C.K., Lam S.K. and Wong B.C.Y., Standard treatment for Helicobacter pylori infection is suboptimal in non-ulcer dyspepsia compared to duodenal ulcer in Chinese, Alimentary Pharmacology and Therapeutics. 2005, 21: 73-81.

Wong W.M., Lai K.C., Lam K.F., Hui W.M., Huang J.Q., Xia H.H.X., Hu H.C., Lam C.L.K., Chan C.K., Lam S.K. and Wong B.C.Y., Onset and disappearance of Reflux Symptoms in a Chinese population: a one-year follow-up study, Alimentary Pharmacology and Therapeutics. 2004, 20: 803-812.

Xia B., Xia H.H.X., Lam S.K., Chan O.O., Lai K.C., Hu H.C. and Wong B.C.Y., Trends in prevalence of peptic ulcer disease and Helicobacter pylori infection and frequency of NSAID intake in general practitioner-referred dyspeptic patients over 6 years in Hong Kong, Gastroenterology. 2005, 128(4 Suppl 2): A230.

Researcher : Huang CY

List of Research Outputs

Ng P.W., Huang C.Y., Cheung R.T.F., Wong K.S., Wong C.K. and Lam J.M., Transient ischaemic attack patients are often under-evaluated, Hong Kong Medical Journal. 2004, 10: 293-294.

Researcher : Huang J

List of Research Outputs

Wong R.W.M., Lai K.C., Hui W.M., Hu H.C., Huang J., Wong Y.H., Xia H.H.X., Chan O.O., Lam S.K. and Wong B.C.Y., Pathophysiology of Gastroesophageal Reflux Diseases in ChineseRole of Transient Lower Esophageal Sphincter Relaxation and Esophageal Motor Dysfunction, American Journal of Gastroenterology. 2004, 99: 2088-2093.

Wong R.W.M., Xiao S.D., HU P.J., Wang W., Gu Q., Huang J., Xia H.H.X., WU S.M., LI C.J., CHEN M.H., CUI Y., Lai K.C., Hu H.C., Chan C.K., Lam S.K. and Wong B.C.Y., Standard treatment for Helicobacter pylori infection is suboptimal in non-ulcer dyspepsia compared to duodenal ulcer in Chinese, Alimentary Pharmacology and Therapeutics. 2005, 21: 73-81.

Researcher : Hui CK

List of Research Outputs

Hui C.K., Lie A., Au W.Y., Leung A.Y.H., Ma S.Y., Cheung W.W., Zhang H., Chim C.S., Kwong Y.L., Liang R.H.S. and Lau G., A long-term follow-up study on hepatitis B surface antigen-positive patients undergoing allogeneic hematopoietic stem cell transplantation, Blood. 2005, 106: 464-9.

Hui C.K. and Lau G., Advances in immunomodulating therapy of HBV infection, Int J Med Sci. 2005, 2: 24-29.

Hui C.K., Bowden S., Jackson K., Au W.Y., Fong D.Y.T., Lie A.K.W., Chim J.C.S., Liang R.H.S. and Lau G., Clinical significance of intrahepatic hepatitis B virus covalently closed circular DNA in chronic hepatitis B patients who received cytotoxic chemotheraphy, Blood. 2005, 105(6): 2616-2617.

Hui C.K., Lie A.K.W., Au W.Y., Ma S.Y., Leung A.Y.H., Zhang H., Sun J.Z., Cheung W.W.W., Chim J.C.S., Kwong Y.L., Liang R.H.S. and Lau G., Effectiveness of prophylactic Anti-HBV therapy in allogeneic hematopoietic stem cell transplantation with HBsAg positive donors, American Journal of Transplantation. 2005, 5(6): 1437-45.

Hui C.K., Emerging Leader in Gastroenterology. 2004.

Hui C.K., Zhang H. and Lau G., Management of chronic hepatitis B in treatment-experienced patients, Gastroenterol Clin North Am. 2004, 33: 601-16.

Hui C.K., Sun J., Au W.Y., Lie A.K.W., Yueng Y.H., Zhang H., Lee N.P., Hou J., Liang R.H.S. and Lau G., Occult hepatitis B virus infection in hematopoietic stem cell donors in a hepatitis B virus endemic area, Journal of Hepatology. 2005, 42(6): 813-9.

Hui C.K., Lai K.C., Wong R.W.M., Yuen R.M.F., Ng M.M.T., Chan C.K., Hu H.C., Cheung W.W., Lai C.L. and Wong B.C.Y., Outpatients Undergoing Therapeutic Endoscopic Retrograde Cholangiopancreatography: Six-hour Versus Overnight Observation , Journal of Gastroenterology and Hepatology. 2004, 19: 1163-1168.

Hui C.K., Cheung B.M.Y. and Lau G., Pharmacokinetics of pitavastatin in subjects with Child-Pugh A and B cirrhosis, Br J Clin Pharmacol. 2005, 59: 291-7.

Hui C.K., Yu J., Au W.Y., Zhang H., Bartholomeusz A., Locarnini S., Kwong Y.L., Liang R.H.S. and Lau G., Sexual transmission of hepatitis B infection despite the presence of hepatitis B virus immunity in recipients of allogeneic bone marrow transplantation, J Clin Virol. 2005, 32: 173-8.

Wong D.K.H., Yuen R.M.F., Tse E.W.C., Yuan H., Sum S.M., Hui C.K. and Lai C.L., Detection of Intrahepatic Hepatitis B Virus DNA and Correlation with Hepatic Necroinflammation and Fibrosis, Journal of Clinical Microbiology. 2004, 42: 3920-3924.

Wong D.K.H., Yuen R.M.F., Yuan H., Sum S.M., Hui C.K., Hall J. and Lai C.L., Quantitation of Covalently Closed Circular Hepatitis B Virus DNA in Chronic Hepatitis B Patients, Hepatology. 2004, 40: 727-737.

Wong R.W.M., Huang J., Xia H.H.X., Fung F.M.Y., Tong S.M., Cheung K.L., Ho Y.K., Lai K.C., Chan C.K., Chan O.O., Hui C.K., Lam S.K. and Wong B.C.Y., Low-dose rabeprazole, amoxicillin and metronidazole triple therapy for the treatment of Helicobacter pylori infection in Chinese patients , Journal of Gastroenterology and Hepatology. 2005, 20(6): 935-940.

Yuen R.M.F., Hon C., Hui C.K., Siu C.W. and Lai C.L., Interferon treatment for metastatic hepatocellular carcinoma. Review Series, Hepatitis. 2004, 3: 12-3.

Yuen R.M.F., Tanaka K., Mizokami M., Yuen J.C.H., Hui C.K., Wong D.K.H., Yuan H., Sum S.M., Chan O.O., Wong B.C.Y., Fan S.T. and Lai C.L., Role of hepatitis B virus genotypes Ba and C, core promoter and precore mutations on hepatocellular carcinoma: a case control study, Carcinogenesis. 2004, 25(9): 1593-1598.

Researcher : Hui WM

List of Research Outputs

Chan O.O., Chu K.M., Sun Y., Cheung K.L., Lam S.K., Yuen R.M.F., Hui W.M. and Wong B.C.Y., The association between Interleukin 1 beta polymorphism and hypermethylation at tumor suppressor genes in gastric cancer. Conference paper at the Annual Meeting of the American Gastroenterology Associatoin, Digestive Diseases Week (DDW) Chicago, Illinois, USA. May 14-19, Gastroenterology. 2005, 128(4 Suppl 2): A399.

Lai K.C., Hui W.M., Wong B.C.Y., Hu H.C., Chan O.O. and Lam S.K., Lansorprazole but not Rofecoxib reduced dyspeptic symptoms of patients on NSAIDS, Gastroenterology. 2005, 128(4 Suppl 2): A24.

Wong R.W.M., Hui W.M. and Wong B.C.Y., Diagnosis of Barrett's esophagus in the Asian population, Journal of Gastroenterology and Hepatology. 2005, 20(3): 495.

Wong R.W.M., Lai K.C., Hui W.M., Hu H.C., Huang J., Wong Y.H., Xia H.H.X., Chan O.O., Lam S.K. and Wong B.C.Y., Pathophysiology of Gastroesophageal Reflux Diseases in ChineseRole of Transient Lower Esophageal Sphincter Relaxation and Esophageal Motor Dysfunction, American Journal of Gastroenterology. 2004, 99: 2088-2093.

Wong R.W.M., Hui W.M. and Wong B.C.Y., Reply from authors, Journal of Gastroenterology and Hepatology. 2005, 20(3): 495.

Wong W.M., Lai K.C., Lam K.F., Hui W.M., Huang J.Q., Xia H.H.X., Hu H.C., Lam C.L.K., Chan C.K., Lam S.K. and Wong B.C.Y., Onset and disappearance of Reflux Symptoms in a Chinese population: a one-year follow-up study, Alimentary Pharmacology and Therapeutics. 2004, 20: 803-812.

Researcher : Hui WS

List of Research Outputs

Chan D., Yang L., Hui W.S., Chan W.C.W., Huang J., Shum D.K.Y., Cheung K.M.C., Luo Z.J. and Cheah K.S.E., A splicing mutation in the ext2 gene affects messenger RNA stability in a family with hereditary multiple exostoses, XIXth Meeting of the Federation of the European Connective Tissue Societies, Taormina-Giardini Noxos, Italy. 9-13 July 2004.

Mak J.C.W., Hui W.S., Johnson M.W., Barnes P.J. and Tsang K.W.T., Modulation of Functional Pulmonary β2-Adrenoceptor by Tansforming Growth Factor-β1 in Human Bronchial Epithelial Cells, Abstract Book of the 10th Medical Research Conference, University Department of Medicine, The University of Hong Kong, 19-20 Feb. 2005, page 61.

Pan N.Y., Hui W.S., Tipoe G.L., Tsang K.W.T. and Mak J.C.W., Effects of Glucocorticosteroids and Antimicrobial Drugs on Inhibition of IL-1β- and PDBu-induced IL-8 Release in the Presence of Pyocyanin in Bronchial Epithelial Cell Line, Abstract Book of the 10th Medical Research Conference, University Department of Medicine, The University of Hong Kong, 19-20 February. 2005, page 62.

Researcher : Ip MSM

Project Title:	The efficacy of the modified oral appliance in the treatment of mild and moderate obstructive Sleep Apnoea
Investigator(s):	Ip MSM
Department:	Medicine
Source(s) of Funding:	Other Funding Scheme
Start Date:	02/1997

Abstract:

To assess the efficacy, side effects and patient acceptance of an oral appliance in the treatment of obstructive sleep apnoea; to define the clinical, anthropometric, polysomnographic and cephalometric characteristics that determine treatment response.

Project Title:	The effect of oral appliance (OA) in treatment of obstructive sleep apnoea
Investigator(s):	Ip MSM, Peh WCG, Cooke MS, Kim S.
Department:	Medicine
Source(s) of Funding:	Other Funding Scheme
Start Date:	06/1997

Abstract:

To study the efficacy of OA in teatment of mild/moderate OSA; to study the safety profile of OA.

Project Title:	Role of adiponectin in obstructive sleep apnoea
Investigator(s):	Ip MSM, Lam KSL, Lam J.
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002

Abstract:

To investigate serum adiponectin levels in OSA patients with a spectrum of body mass index (BMI) and sleep disordered breathing (no OSA to severe OSA) and define correlative parameters; to investigate for any difference in adiponectin levels in patients with OSA and BMI-matched subjects with no OSA (3) the impact of nasal Continuous Positive Airway pressure (nCPAP) treatment on adiponectin secretion in subjects with OSA.

Project Title:	Candidate genes of obstructive sleep apnoea syndrome in Hong Kong Chinese
Investigator(s):	Ip MSM, Lam KSL, Song Y, Sham PC, Lam CL
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2005

Abstract:

Refer to hard copy

List of Research Outputs

Chan M.M.W. and Ip M.S.M., Asthma Management, In: Ip SM, Chan MMW, Zhong NS, Lam WK, In: Respiratory Disease- The Asian Perspective. The University Hong Kong Press, 2005, 25-42.

Chan M.M.W. and Ip M.S.M., Asthma management. In: Ed. Ip MSM, Chan MMW, Lam WK, Zhong NS, Respiratory Medicine - An Asian Perspective. Hong Kong University Press, 2005, pp. 25-42.

Chan M.M.W., Tan-Un K.C., Ip M.S.M., Tsang K.W.T., Ho S.P., Ho J.C.M., Chan H. and Lam W.K., Lung Cancer Susceptibility and Polymorphism of Glutathione-S-transferase Genes in Hong Kong, Lung Cancer. 2004, 45(2): 155-160.

Chan M.M.W., Lam W.K., Mak J.C.W., Ho S.P., Chan H.W., Tsang K.W.T., Ip M.S.M., Ho J.C.M., Wong M.P. and Tan-Un K., Polymorphisms of CYP and GST genes, passive smoke and lung cancer risk in Hong Kong Chinese, European Respiratory Journal. 2004, 24: Suppl 48: 457s.

Ho J.C.M., Lam W.K., Wong M.P., Wong M.K., Ooi C.G.C., Ip M.S.M., Chan M.M.W. and Tsang K.W.T., Lymphoepithelioma-like carcinoma of the lung : experience with ten cases, International Journal of Tuberculosis and Lung Disease. 2004, 8(7): 890-895.

Ho J.C.M., Mak J.C.W., Ho S.P., Ip M.S.M., Tsang K.W.T., Lam W.K. and Chan M.M.W., Manganese superoxide dismutase and catalase genetic polymorphisms activity levels and lung cancer risk in Chinese in Hong Kong, 10th Medical Research Conference, Department of Medicine, The University of Hong Kong, February 2005. Abstract Book: RM 66.

Ho J.C.M., Ho S.P., Chan M.M.W., Mak J.C.W., Ip M.S.M., Ko K.W., Yan C.P.K., Wong M.P., Tsang K.W.T. and Lam W.K., Non-small cell lung cancer in Chinese is associated with disturbance in systemic antioxidant profiles, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December, 2004. Respirology. 2004, 9 (Supp): A114.

Ho S.P., Chan M.M.W., Chow K.M., Ip M.S.M. and Mak J.C.W., Antioxidant enzyme activities in healthy Chinese adults: influence of age, gender, and smoking, Respirology. 2005, 10: 305-309.

Ho S.P., Chan M.M.W., Wong M.P., Tsang K.W.T., Ip M.S.M., Lam W.K. and Mak J.C.W., Transforming growth factor (TGF)-beta 1 gene common polymorphisms and plasma TGF-beta 1 levels in patients with lung cancer, 10th Medical Research Conference, Department of Medicine, The University of Hong Kong, February 2005. Abstract Book: RM 60.

Ho S.P., Chan M.M.W., Tsang K.W.T., Ip M.S.M., Lam W.K. and Mak J.C.W., Transforming growth factor (TGF)-beta 1 gene common polymorphisms and plasma TGF-beta 1 levels in patients with lung cancer, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A120.

Ip M.S.M., Co-chairperson in Parallel Session 2B : Chronic obstructive pulmonary disease, 9th Congress of the Asian acific Society of Respirology, December. 2004.

Ip M.S.M., Associate Editor, CHEST. 2005.

Ip M.S.M., Co-chairperson in Paraellel Session 3B : Sleep Disordered Breathing, 9th Congress of the Asian Pacific Society of Respirology, December. 2004.

Ip M.S.M., Co-chairperson in Presidential best papers presentation , 9th Congress of the Asian Pacific Society of Respirology, December. 2004.

Ip M.S.M., Current status and problems of medical treatment of asthma in Asian countries - working toward the decrease of asthma deaths and improvement in patient QOL, 15th Congress of INTERASTHMA Japan/North Asia, Tokyo, Japan, July 2004. 2004.

Ip M.S.M., Member, Programme Committee, Assembly on Respiration, Neurobiology and Sleep, American Thoracic Society Meeting, May. 2005.

Ip M.S.M., Member, The Dental Council of Hong Kong. 2004.

Ip M.S.M., OSA and the metabolic syndrome, 9th Congress of the Asian Pacific Society of Respirology, Hong Kong, December 2004. 2004.

Ip M.S.M. and Guilleminaut C.G., Obstructive sleep apnea. In: Ed. Ip MSM, Chan MMW, Lam WK, Zhong NS, Respiratory Medicine - An Asian Perspective. Hong Kong University Press, 2005, pp. 135-157.

Ip M.S.M., Obstructive sleep apnoea, obesity and metabolic syndrome, American Thoracic Society International Conference, San Diego, USA. May . 2005.

Ip M.S.M., Tse H.F. and Lam B., Rebuttal to "vascular dysfunction may be mediated by other mechanisms", American Journal of Respiratory and Critical Care Medicine. 2004, 170: 197-198.

Ip M.S.M., Ko K.W., Lau A.C.W., Yu W.C., Tang K.S., Choo K., Ling S.O., Chan J.W. and Chan M.M.W., Reference values of spirometry for adult Chinese in Hong Kong, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A162.

Ip M.S.M., Chan M.M.W., Lam W.K. and Zhong N.S., Respiratory Medicine - An Asian Perspective. Hong Kong University Press, 2005.

Lam B., Sam K., Mok W.Y.W., Lam J.C., Yam L.Y.C., Lam W.K. and Ip M.S.M., A randomized study of three non-surgical treatment options in mild to moderate obstructive sleep apnea, American Thoracic Society International Conference, San Diego, USA. May 2005. Proceedings of the American Thoracic Society. 2005, p.A303.

Lam B., Ip M.S.M., Tench E. and Ryan C.F., Cranofacial profile in Asian and while subjects with obstructive sleep apnoea, Thorax. 2005, 60(6): 504-510.

Lam B., Tam C.M., Lam S.Y., Wong M.P., Ooi C.G.C., Fung S.L., Ip M.S.M. and Lam W.K., Detection of early lung cancer in high risk population : a prospective study, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A122.

Lam J.C., Ooi C.G.C., Tam S., Lam K.S.L. and Ip M.S.M., Insulin resistance and other cardiovascular risk factors in obstructive sleep apnea, American Thoracic Society International Conference, San Diego, USA. May 2005. Proceedings of the American Thoracic Society. 2005, p.A232.

Lam J.C., Lam K.S.L., Tam S., Lam C.L. and Ip M.S.M., The determinants of blood pressure in relation to obstructive sleep apnea, American Thoracic Society International Conference, San Diego, USA. May 2005. Proceedings of the American Thoracic Society. 2005, p.A878.

Lam J.C.M., Ooi C.G.C., Tam S., Khong P.L., Lam B. and Ip M.S.M., Obesity and dyslipidemia in Chinese patients with obstructive sleep apnea, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A143.

Lam J.C.M., Lam K.S.L., Tam S., Yan S.W. and Ip M.S.M., The determinants of blood pressure in relatin to obstructive sleep apnea, 10th Medical Research Conference, Department of Medicine, The University of Hong Kong, February 2005. Abstract Book: RM 58.

Lam J.C.M., Ooi C.G.C., Lam K.S.L., Tam S., Lai A.Y.K., Tsang K.W.T., Lam W.K. and Ip M.S.M., The relationship of insulin resistance, obesity and sleep-disordered breathing , 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology . 2004, 9 (Supp): A143.

Lam J.C.M., Ooi C.G.C., Lam K.S.L., Tam S., Lai A.Y.K., Tsang K.W.T., Lam W.K. and Ip M.S.M., The relationship of insulin resistance, obesity and sleep-disordered breathing, 10th Medical Research Conference, Department of Medicine, The University of Hong Kong, February 2005. Abstract Book: RM 59.

Lam W.K., Tsang K.W.T., Ooi C.G.C., Ip M.S.M. and Chan M.M.W., Infections: Severe Acute Respiratory Syndrome., In: Ip M, Chan-Yeung M, Lam WK, Zhong NS, Respiratory Medicine, An Asian Perspective. Hong Kong, Hong Kong University Press, 2004, 307-323.

Lam W.K., Tsang K.W.T., Ooi C.G.C., Ip M.S.M. and Chan M.M.W., Severe Acute Respiratory Syndrome. In: Ed. Ip MSM, Chan MMW, Lam WK, Zhong NS, Respiratory Medicine - An Asian Perspective. Hong Kong University Press, 2005, Chapter 18: pp. 307-323.

Mak J.C.W., Ho S.P., Leung Y.H., Ho P.L., Ooi C.G.C., Yan C.P.K., Ko K.W., Ip M.S.M., Lam W.K. and Tsang K.W.T., Elevated levels of transforming growth factor- beta 1 in serum of patients with stable bronchiectasis, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A134.

Mak J.C.W., Leung C.M., Ho S.P., Law K.W., Tsang K.W.T., Lam W.K., Ip M.S.M. and Chan M.M.W., Genetic susceptibility of transforming growth factor beta-1 common polymorphisms to Chinese patients with asthma, American Thoracic Society International Conference, San Diego, USA. May 2005. Proceedings of the American Thoracic Society. 2005, p.A78.

Mak J.C.W., Ho J.C.M., Ho S.P., Yu W.C., Yew W.W., Tsang K.W.T., Lam W.K., Ip M.S.M. and Chan M.M.W., Increased oxidative stress and altered antioxidant status in Chinese patients with COPD, European Respiratory Journal. 2004, 24: Suppl 48: 62s.

Mak J.C.W., Ho J.C.M., Ho S.P., Leung C.M., Law K.W., Ip M.S.M. and Chan M.M.W., Polymorphisms of superoxide dismutase and catalase genes and their functional activity levels in Chinese patients with asthma, American Thoracic Society International Conference, San Diego, USA. May 2005. Proceedings of the American Thoracic Society . 2005, p.A78.

Mak J.C.W., Leung H.C., Ho S.P., Lam W.K., Tsang K.W.T., Ip M.S.M. and Chan M.M.W., Systemic antioxidant status in Chinese patients with asthma, European Respiratory Journal. 2004, 24: Suppl 48: 509s.

Mak J.C.W., Leung C.M., Ho S.P., Lam W.K., Tsang K.W.T., Ip M.S.M. and Chan M.M.W., Systemic oxidative and antioxidative status in Chinese patients with asthma, Journal of Allergy and Clinical Immunology. 2004, 114(2): 260-264.

Patil N.G. and Ip M.S.M., The curriculum journey - where are we now?, Curriculum Reform: Foundation to Consolidation. The University of Hong Kong, 2004, 25-34.

Tan K.C.B., Chow W.S., Lam J.C.M., Lam B., Wong W.K., Tam S. and Ip M.S.M., HDL dysfunction in obstructive sleep apnea, Atherosclerosis. 2005-02-01, 2005, Epub ahead of print.

Tan W.C., Mahayiddin A.A., Charoenratanakul S., Zhong N.S., Seal P., Ip M.S.M., de Guia T., Shim Y.S., Chiang C.H. and Mangunnegoro H., GOLD strategy for the diagnosis, management, and prevention of COPD: An Asia-Pacific Perspective. The Asia Pacific COPD Roundable Group, Respirology. 2005, 10: 9-17.

Tsang K.W.T., Ooi C.G.C. and Ip M.S.M., Airway Diseases : Bronchiectasis., In: Ip M, Chan-Yeung M, Lam WK, Zhong NS., Respiratory Medicine, An Asian Perspective.. Hong Kong, Hong Kong University Press, 2004, 43-59.

Tsang K.W.T., Ooi C.G.C. and Ip M.S.M., Bronchiectasis. In: Ed. Ip MSM, Chan MMW, Lam WK, Zhong NS , Respiratory Medicine - An Asian Perspective. Hong Kong University Press, 2005, pp. 43-59.

Wang J., Law K.W., Ip M.S.M., Wu A.Y.Y., Wong M.K., Lam B., Chow K.M. and Chan M.M.W., Effect of asthma self management programme on asthma morbidity and health care utilization in adult patients admitted to hospital with acute asthma in Hong Kong: A randomized controlled trial, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A91.

Wong J.G.W.S., Cheung E.P.T., Cheung V., Cheung C., Chan M.T.Y., Chua S.E., McAlonan G.M., Tsang K.W.T. and Ip M.S.M., Psychological responses to the SARS outbreak in healthcare students in Hong Kong, Medical Teacher. Taylor & Francis health sciences, 2005, 26 (7): 657-663.

Wong M.K., Lam J.C., Ip S.K., Ip M.S.M., Lam W.K. and Tsang K.W.T., A comparative study on the efficacy of sequential intravenous and oral levofloxacin versus ceftazidime in treatment of infective exacerbation of bronchiectasis, 10th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2005, Abstract Book: RM 64.

Wong M.K., Lam J., Ip S., Lam C.L., Ip M.S.M., Lam W.K. and Tsang K.W.T., Quality of life effect of levofloxacin compared to ceftazidime treatment in infective exacerbation of bronchiectasis, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A135.

Researcher : Ip TP

List of Research Outputs

Leung J.Y., Ho A.Y.Y., Ip T.P., Lee G. and Kung A.W.C., The efficacy and tolerability of risedronate on bone mineral density and bone turnover markers in osteoporotic Chinese women: a randomized placebo-controlled study, Bone. 2005, 36(2): 358-64.

Researcher : Jiang X

List of Research Outputs

Jiang X., Tu S., Cui J., Lin M.C., Xia H.H.X., Wong R.W.M., Chan O.O., Yuen M.F., Jiang S.H., Lam S.K., Kung H., Soh J.W., Weinstein I.B. and Wong B.C.Y., Antisense Targeting Protein Kinase C Alpha and Beta1 Inhibits Gastric Carcinogenesis, Cancer Research. 2004, 64: 5787-5794.

Tu S., Cui J., Liston P., Jiang X., Xu R., Lin M.C., Zhu Y.B., Zou B., Ng S.M., Jiang S.H., Xia H.H.X., Wong R.W.M., Chan O.O., Yuen R.M.F., Lam S.K., Kung H. and Wong B.C.Y., Gene Therapy for Colon Cancer by Adeno-Associated Viral Vector-Mediated Transfer of Survivin Cys84Ala Mutant, Gastroenterology. 2005, 128: 361-375.

Researcher : Jin L

List of Research Outputs

Jin L., Lau H.L., Smith D.K., Lau K.S., Cheung P.T., Kwan E.Y.W., Low L.C.K. and Kung A.W.C., A family with osteoporosis-pseudoglioma syndrome (OPG) due to compound heterozygous mutation of the LRO5 gene, 26th Annual Meeting of the American Society for Bone & Mineral Research, October 1-5, 2004, Seattle, USA. Journal of Bone and Mineral Research . 2004, 19(Supl 1): SA125.

Jin L., Lau H.L., Smith D.K., Lau K.S., Cheung P.T., Kwan E.Y.W., Low L.C.K., Chan V.N.Y. and Kung A.W.C., A family with osteoporosis-pseudoglioma syndrome (OPG) due to compound heterozygous mutation of the LRP5 gene, HKU 10th Medical Research Conference. 2005.

Jin L., Lau H.L., Smith D.K., Lau K.S., Cheung P.T., Kwan E.Y.W., Low L.C.K., Chan V.N.Y. and Kung A.W.C., Family with osteoporosis Pseudolioma Syndrome due to compound heterozygosity of two novel mutations of the LRP5 gene, 6th Regional Osteoporosis Conference, 21-22 May 2005, Hong Kong. 2005.

Researcher : Jin O

List of Research Outputs

Jin O., Sun L.Y., Zhou K.X., Zhang X.S., Feng X.B., Mok T.M.Y. and Lau W.C.S., Lymphocyte apoptosis and macrophage function: correlation with disease activity in systemic lupus erythematosus, Clinical Rheumatology. 2005, 24: 107-110.

Jin O., Chan W.K., Mok T.M.Y., Sun L.Y. and Lau W.C.S., Osteopontin (OPN), matrix metalloproteinase (MMP)-3 and lupus nephritis (LN), 11th APLAR Bi-annual Congress, Jeju, Korea 11-16 September 2004.

Researcher : Jin Y

Project Title:	Cytogenetic and molecular genetic characterization of esophageal carcinomas
Investigator(s):	Jin Y, Kwong YL, Tsao GSW
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	10/2002

Abstract:

To identify, by cytogenetic, fluorescence in situ hybridization (FISH), and molecular genetic approaches, the genetic changes that are important in the malignant transformation of esophageal epithelium; to investigate genetic differences and similarity between immortalized, preneoplastic esophageal epithelial cells and aquamous cell carcinoma (SCC) of the esophagus.

List of Research Outputs

Chung C.M., Man W.Y.C., Jin Y., Jin C., Guan X.Y., Wang Q., Wan T.S.K., Cheung A. and Tsao G.S.W., Amplification and overexpression of Aurora kinase A (AURKA) in immortalized human ovarian epithelial (HOSE) cells, Molecular Carcinogenesis. 2005, 43(3): 165-174.

Gisselsson D.L., Lu M., Tsao G.S.W., Man C.W.Y., Jin C., Jin C., HOglund M., Kwong Y.L. and Jin Y., Telomere-mediated mitotic disturbances in immortalized ovarian epithelial cells reproduce chromosomal losses and breakpoints from ovarian carcinoma, Genes, Chromosomes and Cancer. 2004, 42(1): 22-23.

Jin Y., Jin C., Lu M., Tsao G.S.W., Zhu J., Wennerberg J., Mertens F. and Kwong Y.L., Karyotypic evolution and tumor progression in head and neck squamous cell carcinomas , Cancer Genetics and Cytogenetics . 2005, 156(1): 1-7.

Researcher : Ko KW

List of Research Outputs

Ho J.C.M., Ho S.P., Chan M.M.W., Mak J.C.W., Ip M.S.M., Ko K.W., Yan C.P.K., Wong M.P., Tsang K.W.T. and Lam W.K., Non-small cell lung cancer in Chinese is associated with disturbance in systemic antioxidant profiles, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December, 2004. Respirology. 2004, 9 (Supp): A114.

Ho J.C.M., Wu A.Y.Y., Lam B., Ooi C.G.C., Khong P.L., Ho P.L., Chan M.M.W., Zhong N.S., Ko K.W., Lam W.K. and Tsang K.W.T., Pentaglobin in steroid-resistant severe acute respiratory syndrome, International Journal of Tuberculosis and Lung Disease. 2004, 8(10): 1173-1179.

Mak J.C.W., Ho S.P., Leung Y.H., Ho P.L., Ooi C.G.C., Yan C.P.K., Ko K.W., Ip M.S.M., Lam W.K. and Tsang K.W.T., Elevated levels of transforming growth factor- beta 1 in serum of patients with stable bronchiectasis, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A134.

Tsang K.W.T., Tipoe G.L., Sun J.Z., Tan K.C.B., Leung Y.H., Yan C.P.K., Ko K.W., Ooi C.G.C., Ho J.C.M. and Lam W.K., Clinical value of ciliary assessment in bronchiectasis, Lung. 2005, 183(2): 73-86.

Tsang K.W.T., Tan K.C.B., Ho P.L., Ooi C.G.C., Khong P.L., Leung Y.H., Mak J.C.W., Tipoe G.L., Ko K.W. and Lam W.K., Exhaled nitric oxide in bronchiectasis: the effects of inhaled corticosteroid therapy, International Journal of Tuberculosis and Lung Disease. 2004, 8(11): 1301-1307.

Researcher : Kumana CR

List of Research Outputs

Ambekar C.S., Lee J.S.K., Cheung B.M.Y., Chan L.C., Liang R.H.S. and Kumana C.R., Metabolism of Chloramphenicol Succinate, a Competitive Substrate and Inhibitor of Succinate Dehydrogenase: Possible Reason for its Toxicity, Toxicology in Vitro. 2004, 18: 441-7.

Au W.Y., Cheung G.T.Y., Yuen W.H., Kumana C.R. and Kwong Y.L., Successful treatment of relapsed acute promyelocytic leukemia in a patient receiving continuous ambulatory peritoneal dialysis with oral arsenic trioxide, Archite Internal Medicine. 2005, 165: 1067-1068.

Au W.Y., Chim J.C.S., Lie A.K.W., Leung A.Y.H., Tse E.W.C., Ma S.Y., Liang R.H.S., Pang A.W.K., Kumana C.R. and Kwong Y.L., Treatment of relapsed acute promyelocytic leukemia by arsenic-based strategies without hematopoietic stem cell transplantation in Hong Kong: a seven-year experience, American Society of Haematology Annual Scientific Meeting. 2004.

Chan L.S., Cheung G.T.Y., Lauder I.J. and Kumana C.R., Screening For Fever By Remote Sensing Infrared Thermographic Camera, Journal of Travel Medicine. 2004, 11: 273-297.

Cheung B.M.Y., Man Y.B., Tse H.F., Kumana C.R. and Lau C.P., Advantages of Blood Pressure Optimisation Study, J Hong Kong Coll Cardiol . 2004, 12: 33.

Cheung B.M.Y., Lam T.H., Lam K.S.L., Tam S., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Man Y.B., Cheng C.H., Kumana C.R. and Lau C.P., Follow Up of the Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., High Blood Pressure is Related to Obesity in Hong Kong, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Hwang I.S.S., Li C., Tsang K.W.T., Leung Y.H., Kumana C.R. and Tang F., Increased Adrenomedullin Expression in Lungs in Endotoxaemia, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong. 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Lipid Profile of the Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Cheung G.T.Y., Lauder I.J., Lau C.P. and Kumana C.R., Meta-analysis of Large Outcome Trials of Angiotensin Receptor Blockers in Hypertension, American Journal of Hypertension. 2005, 18(5) Suppl: A53.

Cheung B.M.Y., Lauder I.J. and Kumana C.R., Meta-analysis of Large Randomised Controlled Trials that Evaluate Cardiovascular Outcomes After Stain Treatment, 8th Scientific Meeting of the Hong Kong Pharmacology Society in Association with the Shanghai Pharmacology Society, Hong Kong 2004.

Cheung B.M.Y., Lauder I.J. and Kumana C.R., Meta-analysis of Large Randomised Controlled Trials to Evaluate the Impact of Statins on Cardiovascular Outcomes, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong. 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Obesity in the Hong Kong Cardiovascular Risk Factor Prevalence Survey-2 (CRISPS2) Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of Diabetes Mellitus (DM) in the Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Wat N.M.S., Lo L.F., Chau F.Y., Lam T.H., Leung G.M., Tam S., Cheng C.H., Kumana C.R., Lau C.P. and Lam K.S.L., Prevalence of Hypertension in Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort, J Hong Kong Coll Cardiol. 2004, 12: 33.

Cheung B.M.Y., Law C.Y., Ho G.Y.Y., McGhee S.M., Man Y.B., Ng P.P.Y., Kumana C.R. and Lau C.P., Randomised Controlled Trial of Low Salt Diet Versus Drug Treatment in the Management of Mild hypertension, 8th Scientific Meeting of the Hong Kong Pharmacology Socieity in Association with the Shanghai Pharmacology Society, Hong Kong 2004.

Cheung B.M.Y., Law C.Y., Ho G.Y.Y., McGhee S.M., Man Y.B., Ng P.P.Y., Kumana C.R. and Lau C.P., Randomsed Controlled Trial of Low Salt Diet Versus Drug Treatment in Hypertension, Cardiovasc Drugs Thera. 2004, 18 (Suppl) 1: 15.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Relationship Between Hypertension and Obesity in Hong Kong, 3rd Asian-Pacific Congress on Hypertension, Singapore 2004.

Cheung B.M.Y., Lam T.H., Lam K.S.L., Tam S., Wat N.M.S., Man Y.B., Cheng C.H., Kumana C.R. and Lau C.P., The Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort - Results at 7 Years, J Hypertens. 2004, 22 (Suppl 2): S268-269.

Cheung B.M.Y., Law C.Y., McGhee S.M., Ng P.P.Y., Kumana C.R. and Lau C.P., The Relationship Between Sodium and Blood Pressure in Hong Kong Chinese, Clin Res Regul Aff. 2004, 21(2): 145-154.

Kumana C.R., Cheung G.T.Y., Lauder I.J. and Cheung B.M.Y., Long-term combination therapy with aspirin and clopidogrel, J Cardiovasc Pharmacol Ther. 2004, 9(4): 223-5.

Kumana C.R., Cheung B.M.Y., Cheung G.T.Y., Ovedal T., Pederson B. and Lauder I.J., Rhythm vs.rate control of atrial fibrillation meta-analysed by number needed to treat, Br J Clin Pharmacol. Blackwell Publishing Ltd, 2005, 60(4): 347-54.

Kumana C.R., Cheung G.T.Y., Lauder I.J. and Chan L.S., Screening for Fever by Means of Infrared Thermographic Camera, 11th Ineternational Congress of infectious diseases – Mexico 2004 (Published in: International Journal of Infectious Diseases). 2004, 8(Supl 1): S110.

Kumana C.R., Cheung G.T.Y. and Lau W.C.S., Severe digital ischaemia treated with phosphodiesterase inhibitors, Annals of Rheumatic Diseases. 2004, 63: 1522-1524.

Man Y.B., Cheung B.M.Y., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of Hypertension in the Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong. 2004.

Researcher : Kung AWC

Project Title:	To determine the factors affecting the rate of bone loss in southern Chinese
Investigator(s):	Kung AWC, Tang GWK, Ho A.Y.Y.
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002
Completion Date:	10/2004

Abstract:

To measure the rate of bone loss in southern Chinese men and women aged between 45 to 70 by measure BMD at baseline and 2 years later; to determine the environmental and demographic factors that affect the rate of bone loss in southern Chinese men and women; to determine the association of collagen I[alpha]1 gene, estrogen receptor [alpha] and [beta] gene with bone mineral density and rate of bone loss in southern Chinese men and women.

Project Title:	Evaluation of maternal and fetal modulators in the development of postpartum autoimmune thyroiditis in a murine model of experimental autoimmune thyroiditis induced by thyroid peroxidase
Investigator(s):	Kung AWC, Banga J.P.
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Abstract:

To determine the incidence of pregnancy outcome in a murine model of AITD induced by immunizing C57B/6(H2[b]) mice with homologous mouse TPO, and to determine the pathogenicity of anti-TPO Ab against placental and fetal antigen; to determine the severity of postpartum thyroiditis in allogeneic C57B/6(H2[b]) x CBA/J(H2[d]) versus synergeneic C57B/6(H2[b]) x C57B/6(H2[b]) and CBA/J(H2[d]) x CBA/J(H2[d]) animals; to determine the cytokine profile in the above animals during pregnancy and postpartum period

Project Title:	Evaluation of maternal and fetal modulators in the development of postpartum autoimmune thyroiditis in a murine model of experimental autoimmune thyroiditis induced by thyroid peroxidase
Investigator(s):	Kung AWC
Department:	Medicine
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2004

Abstract:

Refer to hard copy

Project Title:	An association screen for osteoporosis susceptibility loci in chromosome 3p
Investigator(s):	Kung AWC, Sham PC, Chan VNY
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Abstract:

To identify novel susceptible loci for osteoporosis using BMD as a quantitative trait by conducting a high-density SNP screen in the gene-rich zone of chromosome 3p.

List of Research Outputs

Au W.Y., Lie A.K.W., Kung A.W.C., Liang R.H.S., Hawkins B.R. and Kwong Y.L., Autoimmune thyroid dysfunction after hematopoietic stem cell transplantation, Bone Marrow Transplantation. 2005, 35(4): 383-8.

Au W.Y., Lie A.K.W., Kung A.W.C., Mak W. and Kwong Y.L., Thyrotoxic periodic paralysis after allogeneic haematopoietic stem cell transplantation, British Journal of Haematology. 2005, 129(1): 160.

Gu J., Lee K.K., Kwan E.Y.W., Lam K.F., Ho A.Y.Y., Tam S. and Kung A.W.C., Determinants of bone mineral density in Asian men, 26th Annual Meeting of the American Society for Bone & Mineral Research, October 1-5, 2004, Seattle, USA. Journal of Bone and Mineral Research. 2004, 19(Supl 1): SU115.

Gu J., Lee K.K., Cheung E.Y.N., Lam K.F., Ho A.Y.Y., Tam S. and Kung A.W.C., Determinants of bone mineral density in Asian men, HKU 10th Medical Research Conference. 2005.

Gu J., Chan V.N.Y. and Kung A.W.C., Determinants of bone mineral density in early postmenopausal Asian women: The significance of family history of fracture, 6th Regional Osteoporosis Conference, 21-22 May 2005, Hong Kong. 2005.

Ho A.Y.Y. and Kung A.W.C., Efficacy and tolerability of Alendronate once-weekly in postmenopausal osteoportic women, 6th Regional Osteoporosis Conference, 21-22 May 2005, Hong Kong. 2005.

Jin L., Lau H.L., Smith D.K., Lau K.S., Cheung P.T., Kwan E.Y.W., Low L.C.K. and Kung A.W.C., A family with osteoporosis-pseudoglioma syndrome (OPG) due to compound heterozygous mutation of the LRO5 gene, 26th Annual Meeting of the American Society for Bone & Mineral Research, October 1-5, 2004, Seattle, USA. Journal of Bone and Mineral Research . 2004, 19(Supl 1): SA125.

Jin L., Lau H.L., Smith D.K., Lau K.S., Cheung P.T., Kwan E.Y.W., Low L.C.K., Chan V.N.Y. and Kung A.W.C., A family with osteoporosis-pseudoglioma syndrome (OPG) due to compound heterozygous mutation of the LRP5 gene, HKU 10th Medical Research Conference. 2005.

Jin L., Lau H.L., Smith D.K., Lau K.S., Cheung P.T., Kwan E.Y.W., Low L.C.K., Chan V.N.Y. and Kung A.W.C., Family with osteoporosis Pseudolioma Syndrome due to compound heterozygosity of two novel mutations of the LRP5 gene, 6th Regional Osteoporosis Conference, 21-22 May 2005, Hong Kong. 2005.

Kendler D., Kung A.W.C., Fuleihan G.E.H., Gonzalez J.G.G., Gaines K.A., Verbruggen N. and Melton M.E., Patient with osteoporosis prefer once weekly to once daily dosing with alendronate, Maturitas . 2004, 48: 243-51.

Khan A.A., Bilezikian J.P., Kung A.W.C., Ahmed M.M., Dubois S., Ho A.Y.Y., Rubin M.R., Shaikh A.M., Silverberg S.J., Standish T.I. and Syed Z.A., Alendronate in primary hyperparathyroidism: a double-blind, randomized, placebo-controlled trial, Journal of Clinical Endocrinology & Metabolism. 2004, 89: 3319-25.

Ku C.F., Lo C.Y., Chan W.F., Kung A.W.C. and Lam K.S.L., Total thyroidectomy replaces subtotal thyroidectomy as the preferred surgical treatment for Graves' disease, ANZ Journal of Surgery. 2005, 75: 528-531.

Kung A.W.C., Pasion E.G., Sofiyan M., Lau E.M.C., Tay B.K., Lam K.S., Wilawan K., Tam F. and Thiebaud D., A comparison of Teriparatide and calcitonin therapy in postmenopausal women with osteoporosis, Osteoporosis Global Conference, 2nd Joint Meeting of European Calcified Tissue and International Bone & Mineral Society, 25-29 June 2005, Geneva, Switzerland. 2005.

Kung A.W.C., Andropause: Current Concept and Management, Annual Scientific Meeting of Hong Kong Doctors’Union. 2004.

Kung A.W.C., Associate Editor, MIMS Endocrinology Guide, Singapore. 2004.

Kung A.W.C., Clinical utility of bone densitometry, 6th Regional Osteoporosis Conference, 21-22 May 2005, Hong Kong. 2005.

Kung A.W.C., Pasion E.G., Sivananthan D.K.S., Chen S., Tay B., Shah G., Tam F., Markey C.M. and Thiebaud D., Comparison of Raloxifene and Bisphosphonates on adherence, health outcomes and treatment satisfaction in postmenopausal Asian women, Osteoporosis Global Conference, 2nd Joint Meeting of European Calcified Tissue and International Bone & Mineral Society, 25-29 June 2005, Geneva, Switzerland. 2005.

Kung A.W.C., Ho A.Y.Y., Ross P.D. and Reginster J.Y., Development of a clinical assessment tool in identifying Asian men with low bone mineral density and comparison of its usefulness to quantitative bone ultrasound, Osteoporosis International. 2004, 16(7): 849-855.

Kung A.W.C., Effects of salt iodization on pregnancy and fetal outcome, World Health Organization Technical Consultative Meeting, 24-26 January 2005, Geneva, Switzerland. 2005.

Kung A.W.C., Estrogens and Androgens on Bone Metabolism, In: HW Deng & YZ Liu, Current Topics in Bone Biology. World Scientific publishing Co Pte Ltd, 2005.

Kung A.W.C., Genetic and environmental determinants of bone mass, 6th Regional Osteoporosis Conference, 21-22 May 2005, Hong Kong. 2005.

Kung A.W.C., Interpreting Abnormal Laboratory Findings: Thyroid Function , 9th Hong Kong Medical Forum. 2004.

Kung A.W.C., Issues of Testosterone in Elderly Men, Annual Meeting of Hong Kong Society of Endocrinology, Metabolism & Reproduction. 2004.

Kung A.W.C., Issues with testosterone in elderly men, 16th Annual Scientific Meeting of Hong Kong Society of Endocrinology, Metabolism and Reproduction. 2004, L1.

Kung A.W.C., Management of osteoporosis in Hong Kong, Clinical Calcium. 2004, 14(9): 108-11.

Kung A.W.C., Lai M.H., Lau H.L. and Chan V.N.Y., Polymorphisms in the promoter region of the estrogen receptor beta gene are associated with higher risks of osteoporosis in both men and women, Osteoporosis Global Conference, 2nd Joint Meeting of European Calcified Tissue and International Bone & Mineral Society, 25-29 June 2005, Geneva, Switzerland. 2005.

Kung A.W.C., Postpartum Thyroiditis (Meet the Professor Session), 12th International Congress of Endocrinology, Lisbon, Portugal, 1- 4 September 2004. 2004.

Kung A.W.C., Reviewer, American Journal of Clinical Nutrition. 2004.

Kung A.W.C., Reviewer, Asian Journal of Surgery. 2004.

Kung A.W.C., Reviewer, Asian Medical Journal. 2004.

Kung A.W.C., Reviewer, Clinical Chemistry. 2004.

Kung A.W.C., Reviewer, Endocrinology. 2004.

Kung A.W.C., Reviewer, European Journal of Clinical Nutrition . 2004.

Kung A.W.C., Reviewer, European Journal of Endocrinology. 2004.

Kung A.W.C., Reviewer, Hong Kong Medical Journal. 2004.

Kung A.W.C., Reviewer, International Journal of Obesity. 2004.

Kung A.W.C., Reviewer, Journal of Clinical Densitometry. 2004.

Kung A.W.C., Reviewer, Journal of Gastroenterology and Hepatology. 2004.

Kung A.W.C., Reviewer, Thyroid . 2004.

Kung A.W.C., Secondary Osteoporosis and Male Osteoporosis, The Family Planning Association of Hong Kong. 2005.

Kung A.W.C., Lau H.L., Paterson A.D., Cheung W.M.W., Luk K.D.K. and Chan V.N.Y., Test of linkage and/or association of genes and bone mineral density in Chinese, 26th Annual Meeting of the American Society for Bone & Mineral Research, October 1-5, 2004, Seattle, USA. Journal of Bone and Mineral Research. 2004, 19(Supl 1): SU159.

Kung A.W.C., X-Ray science, radiation safety & quality assurance, 6th Regional Osteoporosis Conference, 21-22 May 2005, Hong Kong. 2005.

Kung A.W.C., 骨質疏鬆症 II 預防與治療之運動篇 (VCD), 2004.

Kwok C.F., Chan S.M., Lee K.K., Ho A.Y.Y., Chan Y.Y., Li P.F., Wong Y.W., Leung F., Luk K.D.K. and Kung A.W.C., An evaluation of a secondary prevention programme against osteoporosis fractures, 6th Regional Osteoporosis Conference, 21-22 May 2005, Hong Kong. 2005.

Lai M.H., Lau H.L., Chan V.N.Y. and Kung A.W.C., Estrogen receptor beta gene polymorphisms in the promoter region are associated with higher risks of osteoporosis in both men and women, The Endocrine Society’s 87th Annual Meeting, June 4-7, 2005, San Diego, USA. 2005.

Lai M.H., Lau H.L., Chan V.N.Y. and Kung A.W.C., Polymorphisms in the promoter region of the estrogen receptor beta gene are associated with higher risks of osteoporosis in both men and women, HKU 10th Medical Research Conference. 2005.

Lai M.H., Lau H.L., Chan V.N.Y. and Kung A.W.C., Promoter polymorphisms of the estrogen receptor beta gene are associated with higher risks of osteoporosis in both men and women, 6th Regional Osteoporosis Conference, 21-22 May 2005, Hong Kong. 2005.

Lau H.L., Ng M.Y.M., Ho A.Y.Y., Luk K.D.K. and Kung A.W.C., Genetic and environmental determinants of bone mineral density in Chinese women, 26th Annual Meeting of the American Society for Bone & Mineral Research, October 1-5, 2004, Seattle, USA. Journal of Bone and Mineral Research. 2004, 19(Supl 1): M161.

Lau H.L., Ng M.Y.M., Ho A.Y.Y., Luk K.D.K. and Kung A.W.C., Genetic and environmental determinants of bone mineral density in Chinese women, Bone. 2005, 36(4): 700-9.

Leung J.Y., Ho A.Y.Y., Ip T.P., Lee G. and Kung A.W.C., The efficacy and tolerability of risedronate on bone mineral density and bone turnover markers in osteoporotic Chinese women: a randomized placebo-controlled study, Bone. 2005, 36(2): 358-64.

Ng H.P. and Kung A.W.C., Induction of autoimmune thyroiditis and hypothyroidism by immunization of thyroid peroxides (TPO) immunodominant peptide in a mouse model, The Endocrine Society’s 87th Annual Meeting, June 4-7, 2005, San Diego, USA. 2005.

Siu D.C.H., Yeung C.Y., Kung A.W.C., Lau C.P. and Tse H.F., Prevalence, clinical characteristics and outcomes of thyrotoxic dilated cardiomyopathy as the initial presentation in patients with thyrotoxicosis, American Heart Association Annual Scientific Meeting, November 7 - 10, 2004, New Orleans, USA. 2004.

Wat W.Z.M., Leung J.Y.Y. and Kung A.W.C., A study on the prevalence and the effect of vitamin D insufficiency in ambulatory elderly subjects in Hong Kong, 6th Regional Osteoporosis Conference, 21-22 May 2005, Hong Kong. 2005.

Researcher : Kung MHW

List of Research Outputs

Ho W.L., Chan Y.L., Kwok H.H., Mak W., Chu A.C.Y., Kung M.H.W., Ramsden D.B. and Ho S.L., mpp+ Modulates Mitochondrial Uncoupling Protein Ucp2, Ucp4 And Ucp5 Expression In Catecholaminergic (sk-n-sh) Cells , J Neurosci Res. 2005, 81(2): 261-8.

Ho W.L., Chan Y.L., Leung K.C., Kung M.H.W., Ramsden D.B. and Ho S.L., Potential Role Of Uncoupling Proteins, Ucp2, -4, And -5, In The Neuroprotective Effects Of Estrogen On Mpp+-induced Neurotoxicity. , 8th International Congress of Parkinson's disease & Movement Disorders, Rome, Italy. 2004.

Ho W.L., Kwok H.H., Chu C.Y.A., Ho W.M., Kung M.H.W., Ramdsen D.B. and Ho S.L., Silencing of UCP5 enhances MPP+-induced neurotoxicity in SH-SY5Y cells., 9th International Congress of Parkinson’s disease & Movement Disorders, New Orleans, USA. 2005.

Researcher : Kwan TF

List of Research Outputs

Leung A.Y.H., Mendenhall E.M., Kwan T.F., Liang R.H.S., Eckfeldt C., Chen E., Hammerschmidt M., Grindley S., Ekker S.C. and Verfaillie C.M., Characterization of expanded intermediate cell mass in zebrafish chordin morphant embryos, Developmental Biology. 2005, 277(1): 235-254.

Researcher : Kwok HH

List of Research Outputs

Ho W.L., Chan Y.L., Kwok H.H., Mak W., Chu A.C.Y., Kung M.H.W., Ramsden D.B. and Ho S.L., mpp+ Modulates Mitochondrial Uncoupling Protein Ucp2, Ucp4 And Ucp5 Expression In Catecholaminergic (sk-n-sh) Cells , J Neurosci Res. 2005, 81(2): 261-8.

Ho W.L., Kwok H.H., Chu C.Y.A., Ho W.M., Kung M.H.W., Ramdsen D.B. and Ho S.L., Silencing of UCP5 enhances MPP+-induced neurotoxicity in SH-SY5Y cells., 9th International Congress of Parkinson’s disease & Movement Disorders, New Orleans, USA. 2005.

Researcher : Kwok HH

List of Research Outputs

Researcher : Kwok PW

List of Research Outputs

Kwok P.W., Leung Y.H., Sun J.Z., Yan C.P.K., Ooi C.G.C., Ho P.L., Ho J.C.M., Tipoe G.L., Lam W.K. and Tsang K.W.T., The Effects of Gelomyrtol Forte on Human Ciliary Beat Frequency in vitro, Abstract Book of the 10th Medical Research Conference, University Department of Medicine, The University of Hong Kong, 19-20 February. 2005, page 65.

Researcher : Kwong YL

Project Title:	Provision of purine analogues for the treatment of patients with chronic lymphoid malignancies
Investigator(s):	Kwong YL, Liang RHS
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	07/1997

Abstract:

To provide purine analogues for the treatment of patients with chronic lymphoid malignancies who cannot otherwise afford the drugs.

Project Title:	Molecular mechanisms and consequences of downregulation of p73 in natural killer cell lymphoma
Investigator(s):	Kwong YL, Siu L.L.P.
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002

Abstract:

To define if p73 acts as a tumor suppressor gene in natural killer (NK) cell lymphomas; to define the biologic significance of re-expression of p73 in NK lumphoma cells that have p73 inactivated due to aberrant promoter methylation; to define the potential significance of p21 inactivation in NK lymphoma cells.

Project Title:	Molecular basis of arsenic resistance in tumours
Investigator(s):	Kwong YL, Tse EWC
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Abstract:

To define the molecular basis of arsenic resistance in tumour cells.

Project Title:	Activation of the JAK/STAT pathways in the molecular pathogenesis of natural killer cell lymphomas
Investigator(s):	Kwong YL
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Abstract:

To define the involvement of JAK/STAT, MEK/ERK and PI3-K/Akt signaling pathways in the pathogenesis of natural killer (NK) cell lymphomas.

Project Title:	Provision of free cytogenetic and molecular testing for monitoring of disease relapse after bone marrow transplantation
Investigator(s):	Kwong YL, Liang RHS, Lie AKW, Au WY
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	11/2004

Abstract:

To establish provisions of (a) free molecular / cytogenetic tests for monitoring of BMT patients, (b) free molecular / cytogenetic tests for BMT patients who have relapsed, so that their treatment can be guided and optimized, (c) free molecular / cytogenetic tests for referral patients from other hospitals.

List of Research Outputs

Au W.Y., Lie A.K.W., Kung A.W.C., Liang R.H.S., Hawkins B.R. and Kwong Y.L., Autoimmune thyroid dysfunction after hematopoietic stem cell transplantation, Bone Marrow Transplantation. 2005, 35(4): 383-8.

Au W.Y., Ma S.Y., Chim J.C.S., Choy C., Loong F., Lie A.K.W., Lam C.C.K., Leung A.Y.H., Tse E.W.C., Yau C.C., Liang R.H.S. and Kwong Y.L., Clinicopathologic features and treatment outcome of mature T-cell and natural killer-cell lymphomas diagnosed according to the World Health Organization classification scheme: a single center experience of 10 years, Annals of Oncology. 2005, 16(2): 206-214.

Au W.Y., Ma E.S.K., Lam V.M.S., Chan L.C., Pang A.W.K. and Kwong Y.L., Glucose 6-phosphate dehydrogenase (G6PD) deficiency in elderly Chinese women heterozygous for G6PD variants, American Journal of Medical Genetics Part A. 2004, 129A(2): 208 - 211.

Au W.Y., Chan C., Pang A., Lie A.K.W., Liang R.H.S., Yuen P.W., Shek T.W.H., Kwong Y.L. and Pang A.W.K., Nonhematologic malignancies after allogeneic hematopoietic stem cell transplantation: incidence and molecular monitoring, Bone Marrow Transplantation. 2004, 34: 981-985.

Au W.Y., Mak W., Ho S.L., Leung S.Y. and Kwong Y.L., Reversible paraneoplastic neuropathy associated with T-cell large granular lymphocyte leukemia, Neurology. 2004, 63(3): 588-589.

Au W.Y., Lie A.K.W., Liang R.H.S., Yuen P.W., Shek T.W.H. and Kwong Y.L., Secondary non-hematologic malignancies after allogeneic stem cell transplantation : incidence and molecular monitoring, 10th Congress of the International Society of hematology, Asian Pacific Division, Nagoya, Japan. Nagoya, Japan, 2004, 110.

Au W.Y., Cheung G.T.Y., Yuen W.H., Kumana C.R. and Kwong Y.L., Successful treatment of relapsed acute promyelocytic leukemia in a patient receiving continuous ambulatory peritoneal dialysis with oral arsenic trioxide, Archite Internal Medicine. 2005, 165: 1067-1068.

Au W.Y., Lie A.K.W., Kung A.W.C., Mak W. and Kwong Y.L., Thyrotoxic periodic paralysis after allogeneic haematopoietic stem cell transplantation, British Journal of Haematology. 2005, 129(1): 160.

Au W.Y., Srivastava G., Wong K.Y., Chung L.P., Ma E.S.K., Wan T.S.K. and Kwong Y.L., Transformation of diffuse large B-cell lymphoma into pre-B acute lymphoblastic leukemia: clinicopathologic features and clonal relationship, Human Pathology. 2004, 35(7): 900-903.

Au W.Y., Chim J.C.S., Lie A.K.W., Leung A.Y.H., Tse E.W.C., Ma S.Y., Liang R.H.S., Pang A.W.K., Kumana C.R. and Kwong Y.L., Treatment of relapsed acute promyelocytic leukemia by arsenic-based strategies without hematopoietic stem cell transplantation in Hong Kong: a seven-year experience, American Society of Haematology Annual Scientific Meeting. 2004.

Chim J.C.S., Ma E.S.K., Loong F. and Kwong Y.L., Diagnostic cues for natural killer cell lymphoma: primary nodal presentation and the role of in situ hybridisation for Epstein-Barr virus encoded early small RNA in detecting occult bone marrow involvement, Journal of clinical pathology. 2005, 58(4): 443-5.

Chim J.C.S. and Kwong Y.L., How frequent is SOCS1 methylation in acute myeloid leukaemia?, British Journal of Haematology. 2004, 127(5): 609-11.

Gisselsson D.L., Lu M., Tsao G.S.W., Man C.W.Y., Jin C., Jin C., HOglund M., Kwong Y.L. and Jin Y., Telomere-mediated mitotic disturbances in immortalized ovarian epithelial cells reproduce chromosomal losses and breakpoints from ovarian carcinoma, Genes, Chromosomes and Cancer. 2004, 42(1): 22-23.

Hui C.K., Lie A., Au W.Y., Leung A.Y.H., Ma S.Y., Cheung W.W., Zhang H., Chim C.S., Kwong Y.L., Liang R.H.S. and Lau G., A long-term follow-up study on hepatitis B surface antigen-positive patients undergoing allogeneic hematopoietic stem cell transplantation, Blood. 2005, 106: 464-9.

Hui C.K., Lie A.K.W., Au W.Y., Ma S.Y., Leung A.Y.H., Zhang H., Sun J.Z., Cheung W.W.W., Chim J.C.S., Kwong Y.L., Liang R.H.S. and Lau G., Effectiveness of prophylactic Anti-HBV therapy in allogeneic hematopoietic stem cell transplantation with HBsAg positive donors, American Journal of Transplantation. 2005, 5(6): 1437-45.

Hui C.K., Yu J., Au W.Y., Zhang H., Bartholomeusz A., Locarnini S., Kwong Y.L., Liang R.H.S. and Lau G., Sexual transmission of hepatitis B infection despite the presence of hepatitis B virus immunity in recipients of allogeneic bone marrow transplantation, J Clin Virol. 2005, 32: 173-8.

Jin Y., Jin C., Lu M., Tsao G.S.W., Zhu J., Wennerberg J., Mertens F. and Kwong Y.L., Karyotypic evolution and tumor progression in head and neck squamous cell carcinomas , Cancer Genetics and Cytogenetics . 2005, 156(1): 1-7.

Kwong Y.L., Association of T-cell large granular lymphocytic leukaemia with autologous haematopoietic stem cell transplantation: real or fortuitous, Bone Marrow Transplantation. 2005, 35: 625.

Kwong Y.L., Tse H.F. and Lau C.P., Comparative evaluation of platelet and coagulation activation during transvenous cryoablation and radiofrequency ablation for pulmonary veinablation in patients with atrial fibrillation, J Am Coll Cardiol 2005. 45: 120A.

Kwong Y.L., Interpreting Abnormal Laboratory Findings: Anaemia , 9th Hong Kong Medical Forum. 2004.

Kwong Y.L., Pure red cell aplasia with a clonal T-cell disorder, Annals of Hematology. 2005, 84(2): 122-123.

Kwong Y.L. and Liang R.H.S., Treatment of natural killer cell malignancies, The Lymphoid Malignancies, Editor Lan Magrath, Third Edition. 2005.

Leung A.Y.H. and Kwong Y.L., BK virus: a frequent cause of infection in transplant patients, Infection. 2005.

Leung A.Y.H., Chan M.T.L., Yuen K.Y., Cheng V.C.C., Chan K.H., Wong L.P., Liang R.H.S., Lie A.K.W. and Kwong Y.L., Ciprofloxacin Decreased Polyoma BK Virus Load in Patients Who Underwent Allogeneic Hematopoietic Stem Cell Transplantation, Clinical Infectious Disease. 2005, 40: 528-537.

Leung A.Y.H., Chan M.T.L. and Kwong Y.L., Genotyping of the noncoding control region of BK virus in patients with haemorrhagic cystitis after allogeneic haematopoietic stem cell transplantation, Bone Marrow Transplantation. 2005, 35: 531?532.

Leung A.Y.H., Chan M.T.L., Cheng V.C.C., Lie A.K.W., Yuen K.Y. and Kwong Y.L., Polyoma BK viruria in patients undergoing autologous hematopoietic stem cell transplantation, Bone Marrow Transplantation. 2005, 35: 1029?1030.

Leung A.Y.H., Chan M.T.L., Cheng V.C.C., Yuen K.Y. and Kwong Y.L., Quantification of Adenovirus in the Lower Respiratory Tract of Patients without Clinical Adenovirus-Related Respiratory Disease, Clinical Infectious Disease. 2005, 40: 1541-1544(online).

Lie A.K.W., Au W.Y., Ma S.Y., Leung A.Y.H., Tse E.W.C., Chan G.C.F., Ha S.Y., Lau Y.L., Kwong Y.L. and Liang R.H.S., Haemopoietic stem cell transplantation in Hong Kong – 14 years of experience at Queen Mary Hospital, 10th Congress of the International Society of hematology, Asian Pacific Division, Nagoya, Japan. Nagoya, Japan, 2004.

Ma S.Y., Au W.Y., Lie A.K., Ng I.O.L., Leung A.Y.H., Tse E.W.C., Liang R.H.S., Lau G. and Kwong Y.L., Liver graft-versus-host disease after donor lymphocyte infusion for relapses of hematologic malignacies post allogeneic hematopoietic stem cell transplantation, Bone Marrow Transplant. 2004, 34: 57-61.

Pang A.W.K., Au W.Y. and Kwong Y.L., Caveolin-1 gene is coordinately regulated with the multidrug resistance 1 gene in normal and leukemic bone marrow , Leukemia Research . 2004, 28(9): 973-977.

Pang R.W.C., Lee K.W., Man K., Poon R.T.P., Fan S.T., Kwong Y.L. and Tse E.W.C., RNAi-mediated silencing of PIN1 inhibits HCC tumorigenicity (Abstract) , The 96th Annual Meeting of the American Association for Cancer Research, Anaheim, California, U.S.A., 16-20 April 2005.

Pang W.C., Lee K.W., Man K., Poon R.T.P., Fan S.T., Kwong Y.L. and Tse E.W.C., Inhibition of hepatocellular carcinoma tumourigenicity by RNAi-mediated PIN1 silencing (Abstract), The 6th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 8 January 2005.

Pang W.C., Lee K.W., Man K., Poon R.T.P., Fan S.T., Kwong Y.L. and Tse E.W.C., RNAi-mediated PIN1 silencing inhibits HCC trumourigenicity (Abstract), Asian Journal of Surgery. 2005, 28(Suppl 2): S84.

Pang W.C., Lee K.W., Man K., Poon R.T.P., Fan S.T., Kwong Y.L. and Tse E.W.C., RNAi-mediated PIN1 silencing inhibits HCC tumourigenicity (Abstract), The 4th International Meeting on Hepatocellular Carcinoma: Eastern and Western Experiences, Hong Kong, 14-16 December 2004.

Pang W.C., Lee K.W., Man K., Poon R.T.P., Fan S.T., Kwong Y.L. and Tse E.W.C., RNAi-mediated silencing of PIN1 inhibits HCC tumorigenicity, The 11th Hong Kong International Cancer Congress, Hong Kong, 10-12 November, 2004.

Srivastava G., Shen L., Au W.Y., Kwong Y.L. and Liang R.H.S., Molecular pathogenesis of nasal NK/T-cell lymphoma, Abstract of the Proc of 63rd Annual Meeting of the Japanese Cancer Association, 29 September - 1 October 2004, Fukuoka, Japan. 2004.

Szeto C.H., Shek T.W.H., Lie A.K.W., Au W.Y., Yuen P.W. and Kwong Y.L., Squamous cell carcinoma of the tongue complicating chronic oral mucosal graft-versus-host disease after allogeneic hematopoietic stem cell transplantation, American Journal of Hematology. 2004, 77(2): 200-202.

Wong T.S., Kwong D.L.W., Sham J.S.T., Wei W.I., Kwong Y.L. and Yuen P.W., Elevation of plasma osteopontin level in patients with undifferentiated nasopharyngeal carcinoma, European Journal of surgical Oncology. 2005, 31: 555-558.

Researcher : Lai AYK

List of Research Outputs

Lam J.C.M., Ooi C.G.C., Lam K.S.L., Tam S., Lai A.Y.K., Tsang K.W.T., Lam W.K. and Ip M.S.M., The relationship of insulin resistance, obesity and sleep-disordered breathing , 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology . 2004, 9 (Supp): A143.

Lam J.C.M., Ooi C.G.C., Lam K.S.L., Tam S., Lai A.Y.K., Tsang K.W.T., Lam W.K. and Ip M.S.M., The relationship of insulin resistance, obesity and sleep-disordered breathing, 10th Medical Research Conference, Department of Medicine, The University of Hong Kong, February 2005. Abstract Book: RM 59.

Researcher : Lai CL

List of Research Outputs

Chang T.T., Lai C.L., Chien R.N., Guan R., Lim S.G., Lee C.M., Ng K.Y., Nicholls G.J., Dent J.C. and Leung N.W.Y., Four Years of Lamivudine Treatment in Chinese Patients with Chronic Hepatitis B. , Journal of Gastroenterology and Hepatology. 2004, 19: 1276-1282.

Hui C.K., Lai K.C., Wong R.W.M., Yuen R.M.F., Ng M.M.T., Chan C.K., Hu H.C., Cheung W.W., Lai C.L. and Wong B.C.Y., Outpatients Undergoing Therapeutic Endoscopic Retrograde Cholangiopancreatography: Six-hour Versus Overnight Observation , Journal of Gastroenterology and Hepatology. 2004, 19: 1163-1168.

Lai C.L., Lim S.G., Brown N.A., Zhou X.J., Lloyd D.M., Lee Y.M., Yuen R.M.F., Chao G.C. and Myers M.W., A Dose-finding Study of Once-daily Oral Telbivudine in HBeAg-positive Patients with Chronic Hepatitis B Virus Infection, Hepatology. 2004, 40: 719-726.

Lai C.L., Adefovir as First Line Nucleoside Analogue for Chronic Hepatitis B: PRO, Asian Pacific Association for the Study Liver -2004 Conference. 2004.

Lai C.L., Advances in Treatment of Hepatiits B Infection, Alimentary Disease Weekend. 2004.

Lai C.L., Chemoprophylaxis for Hepatocellular Carcinoma, 4th International Meeting on HCC: East & Western Experiences. 2004.

Lai C.L., Chronic B Hepatitis, Management and Research Updated, Continuous Medical Education in Internal Medicine 2004/2005 organized by Servicos de Saude of Governo da Regiao Administrativa Especial de Macau, Macau. 2005.

Lai C.L., Cirrhosis and carcinoma: what are the predictors of progression?” at the BMS supported, CME-accredited symposium “Building new strategies in chronic hepatitis B, 55th Annual Meeting of the American Association for the Study of Liver Disease . 2004.

Lai C.L. and Young R.T.T., Co-chaired the session of “Interpreting Abnormal Laboratory Findings” , 9th Hong Kong Medical Forum. 2004.

Lai C.L., Double-Blind, Placebo-Controlled Trial of Emtricitabine (FTC, EmtrivaR) Administered Once-Daily for Treatment of Chronic Hepatitis B Virus (HBV) Infection, 55th Annual Meeting of the American Association for the Study of Liver Disease. 2004.

Lai C.L., Editor for Hepatology, Journal of Gastroenterology and Hepatology. 2005.

Lai C.L., Emerging Therapeutic Problems in Chronic Hepatitis B – A New Treatment Option for HBeAg-negative Patients, Asian Pacific Association for the Study Liver -2004 conference . 2004.

Lai C.L., Han K.H., Yoon S.K., Um S.H., Yuen R.M.F., Kim H.S., Kim H.R., Chung H.C., Kim C.R., Hsyu P., Averett D. and Kim J., Interim Report for a Phase II, Multi-centre, Dose-escalating Study of LB80380/ANA380 in Hepatitis B Patients with Lamivudine-resistant YMDD Mutant HBV, Journal of Hepatology. 2005, 42 (Suppl 2): 31.

Lai C.L. and Yuen R.M.F., Interpreting Abnormal Laboratory Findings: Liver Function , 9th Hong Kong Medical Forum. 2004.

Lai C.L., Invited Co-Moderator for Symposium on “Infective Liver Disease – An Update of Epidemiology and Management” , Asian Pacific Disgestive Week 2004 . 2004.

Lai C.L., Liver cancer, Cancer Prevention and Health – Expo 2004 organised by Lions Club of Hong Kong. 2004.

Lai C.L., Liver cirrhosis and liver cancer, International Forum on Liver Fibrosis 2004. 2004.

Lai C.L., Management of Asymptomatic HBsAg-positive Subjects with Normal ALT and HBV DNA >100000 copies/ml, Asian Pacific Association for the Study Liver -2004 Conference. 2004.

Lai C.L., Management of Chronic Hepatitis B and Update on Entecaivr, BMS Satellite Symposium, KASL Spring Congress 2005. 2005.

Lai C.L., Management of Chronic Hepatitis B and Update on Entecavir Global Studies, BMS Satellite Symposium at the 12th National Congress for Viral Hepatitis and Liver Diseases . 2005.

Lai C.L., Member of the Editorial Board, World Journal of Gastroenterology. 2004.

Lai C.L., New Antiviral Agents for Chronic Hepatitis B” at the Meet-the-Expert session, Asian Pacific Association for the Study Liver -2004 conference. 2004.

Lai C.L., New Insights in Antiviral Treatment of Chronic Hepatitis B, Asian Pacific Digestive Week. 2004.

Lai C.L., Outstanding Researcher Award, The University of Hong Kong. 2004.

Lai C.L., Phase II Multi-center, Dose-escalating Study of LB80380(ANA380) in Hepatitis B Patients with Lamivudine-resistant YMDD Mutant HBV, 40th Annual Meeting of the European Association for the Study of the Liver. 2005.

Lai C.L., Phase IIb Extended-Treatment Trial of Telbivudine (LdT) vs. Lamivudine vs. Combination Treatment in Hepatitis B Patients: Two-Year Results, Digestive Disease Week. 2005.

Lai C.L., President, Medical Society, Hong Kong University Students' Union. 2005.

Lai C.L., Review/Critique of studies on natural history of hepatitis B, AASLD-APASL Research Workshop on Epidemiology and Natural History of Liver Diseases in Asia. 2004.

Lai C.L., Reviewer, Antiviral Research. 2004.

Lai C.L., Reviewer, CHBG Review. 2004.

Lai C.L., Reviewer, Carcinogenesis. 2004.

Lai C.L., Reviewer, Digestive and Liver Disease. 2004.

Lai C.L., Reviewer, Expert Opinion on Investigational Drugs. 2004.

Lai C.L., Reviewer, Gastroenterology. 2004.

Lai C.L., Reviewer, Hepatology. 2004.

Lai C.L., Reviewer, Journal of Gastroenterology and Hepatology. 2004.

Lai C.L., Reviewer, Journal of Infectious Diseases. 2004.

Lai C.L., Reviewer, Journal of Medical Virology. 2004.

Lai C.L., Reviewer, Journal of Viral Hepatitis. 2004.

Lai C.L., Reviewer, NIDDK. 2004.

Lai C.L., Reviewer, NMRC. 2004.

Lai C.L., Reviewer, New England Journal of Medicine. 2004.

Lai C.L., Reviewer, The Lancet. 2004.

Lai C.L., Reviewer, Vaccine. 2004.

Lai C.L., Treatment of HBV Infection, the seminar on viral hepatitis for nurses 2005 organized by Department of Health, Hong Kong . 2005.

Lai C.L., Update on the Nature History of Chronic Hepatitis B , 9th Hong Kong Medical Forum. 2004.

Lai C.L., Brown N.A., Yuen R.M.F., Wai C.T., Lloyd D., Pietropaolo K., Zhou X.J., Chao G. and Lim S.G., Valtorcitabine provides potent suppression of hepatitis B virus in patients with chronic hepatitis B: Results of a phase I/II clinical trial. , 55th Annual Meeting of the American Association for the Study of Liver Diseases, Boston, USA 29 Oct-2 Nov 2004 (Published in Hepatology) . 2004, 40(4): 173A.

Lai C.L., “New Insights in Antiviral Treatment of Chronic Hepatitis B” at the Continuing Education Seminar, “Lamivudine, Adefovir and New Antiviral Agents” organized by Pharmacy Central Continuing Education Committee. 2004.

Lim S.G., Lai C.L., Myers M., Yuen R.M.F., Wai C.T., Lloyd D., Pietropalolo K., Zhou X.J., Chao G. and Brown N.A., Final Results of a Phase I/II Dose Escalation Trial of Valtorcitabine in Patients with Chronic Hepatitis B, Journal of Hepatology. 2005, 42 (Suppl 2): 16.

Liu C.L., Fan S.T., Lo C.M., Wei W.I., Chan S.C., Yong B.H., Lai C.L. and Wong J., Operative outcomes of adult-to-adult right lobe live donor liver transplantation: a comparative study with cadaveric whole-graft liver transplantation in a single center (Abstract), The 20th International Congress of the Transplantation Society, Vienna, Austria, 5-10 September 2004.

Lo C.M., Fan S.T., Liu C.L., Yong B.H., Wong Y., Lau G., Lai C.L., Ng I.O.L. and Wong J., Lessons learned from one hundred right lobe living donor liver transplants, Annals of Surgery. 2004, 240(1): 151-158.

Mohamed R., Desmond P., Suh D.J., Amarapurkar D., Gane E., Guangbi Y., Hou J.L., Jafri W., Lai C.L., Lee C.H., Lee S.D., Lim S.G., Guan R., Phiet P.H., Piratvisuth T., Sollano J. and Wu J.C., Practical Difficulties in the Management of Hepatitis B in the Asia-Pacific Region, Journal of Gastroenterology and Hepatology. 2004, 19: 958-969.

Sum S.M., Wong D.K.H., Yuen R.M.F., Yuen H., Yu J., Lai C.L., Ho D. and Zhang L., Real-time PCR Assay Using Molecular Beacon for Quantitation of Hepatitis B Virus DNA, Journal of Clinical Microbiology. 2004, 42: 3438-3440.

Wong D.K.H., Yuen R.M.F., Tse E.W.C., Yuan H., Sum S.M., Hui C.K. and Lai C.L., Detection of Intrahepatic Hepatitis B Virus DNA and Correlation with Hepatic Necroinflammation and Fibrosis, Journal of Clinical Microbiology. 2004, 42: 3920-3924.

Wong D.K.H., Yuen R.M.F., Yuan H., Sum S.M., Hui C.K., Hall J. and Lai C.L., Quantitation of Covalently Closed Circular Hepatitis B Virus DNA in Chronic Hepatitis B Patients, Hepatology. 2004, 40: 727-737.

Yuan H., Yuen R.M.F., Wong D.K.H., Sum S.M. and Lai C.L., Clinical Evaluation of the Digene Hybrid Capture II Test and the COBAS AMPLICOR Monitor Test for Determination of Hepatitis B Virus DNA Levels, Journal of Clinical Microbiology. 2004, 42: 3513-3517.

Yuan H., Yuen R.M.F., Wong D.K.H., Sum S.M., Doutreloigne J., Sablon E. and Lai C.L., Determinants for the Occurrence of Acute Exacerbation of Hepatitis B Virus Infection in Chinese Patients after HBeAg Seroclearance , Journal of Clinical Microbiology. 2005, 43: 1594-1599.

Yuen M.F., Ng I.O.L., Fan S.T., Yuan H., Wong D.K.H., Yuen J.C.H., Sum S.M., Chan O.O. and Lai C.L., Significance of HBV DNA levels in liver histology of HBeAg and anti-HBe positive patients with chronic hepatitis B, American Journal of Gastroenterology. 2004, 99(10): 2032-2037.

Yuen R.M.F., Lim W.L., Chan O.O., Wong D.K.H., Sum S.M. and Lai C.L., 18-year follow-up study of a prospective randomized trial of hepatitis B vaccinations without booster doses in children, Clinical Gastroenterology and Hepatology. 2004, 2(10): 941-5.

Yuen R.M.F. and Lai C.L., Adefovir dipivoxil in chronic hepatitis B infection, Expert Opinion on Pharmacotherapy. 2004, 5(11): 2361-7.

Yuen R.M.F., Wong D.K.H., Sum S.M., Yuan H., Yuen J.C.H., Chan O.O., Wong B.C.Y. and Lai C.L., Effect of lamivudine therapy on the serum covalently closed circular DNA of chronic hepatitis B infection., 55th Annual Meeting of the American Association for the Study of Liver Diseases, Boston, USA 29 Oct-2 Nov 2004 (Published in Hepatology). 2004, 40(4): 671A.

Yuen R.M.F., Wong D.K.H., Sum S.M., Yuan H., Yuen J.C.H., Chan O.O., Wong B.C.Y. and Lai C.L., Effect of lamivudine therapy on the serum covalently closed-circular (ccc) DNA of chronic hepatitis B infection., American Journal of Gastroenterology. 2005, 100(5): 1099-103.

Yuen R.M.F., Sablon E., Tanaka Y., Kato T., Mizokami M., Doutreloigne J., Yuan H., Sum S.M. and Lai C.L., Epidemiological study of hepatitis B virus genotypes, core promoter and precore mutations of chronic hepatitis B infection in Hong Kong. , Journal of hepatology : the journal of the European Association for the Study of the Liver. 2004, 41(1): 119-25.

Yuen R.M.F., Wong D.K.H., Yuan H., Sum S.M. and Lai C.L., HBsAg seroclearance in Chinese patients receiving lamivudine therapy for chronic hepatitis B virus infection, Journal of Clinical Microbiology. 2004, 42(10): 4882-4.

Yuen R.M.F., Ip P., Ng W.K. and Lai C.L., Hepatotoxicity due to a formulation of Ganoderma lucidum (lingzhi)., Journal of hepatology : the journal of the European Association for the Study of the Liver. 2004, 41(4): 686-7.

Yuen R.M.F., Wong D.K.H., Chan C.S., Zhang Z., Yuen J.C.H. and Lai C.L., Immune Response During Immunoclearance Phase of Chinese Patients with HBV Genotypes B and C, Journal of Hepatology. 2005, 42 (Suppl 2): 152.

Yuen R.M.F., Hon C., Hui C.K., Siu C.W. and Lai C.L., Interferon treatment for metastatic hepatocellular carcinoma. Review Series, Hepatitis. 2004, 3: 12-3.

Yuen R.M.F., Chow D.H.F., Tsui K., Wong B.C.Y., Yuen J.C.H., Wong D.K.H. and Lai C.L., Liver histology of Asian patients with chronic hepatitis B on prolonged lamivudine therapy, Alimentary Pharmacology and Therapeutics. 2005, 21(7): 841-9.

Yuen R.M.F., Yuan H., Sablon E., Wong D.K.H., Chan O.O., Wong B.C.Y. and Lai C.L., Long-term follow-up study of Chinese patients with YMDD mutations: significance of hepatitis B virus genotypes and characteristics of biochemical flares, Journal of Clinical Microbiology. 2004, 42(9): 3932-6.

Yuen R.M.F., Fung S.K., Tanaka Y., Kato T., Mizokami M., Yuen J.C.H., Wong D.K.H., Yuan H., Sum S.M., Chan O.O., Wong B.C.Y. and Lai C.L., Longitudinal study of hepatitis activity and viral replication before and after HBeAg seroconversion in chronic hepatitis B patients infected with genotypes B and C., Journal of Clinical Microbiology. 2004, 42(11): 5036-40.

Yuen R.M.F., Kim J., Averett D., Wong D.K.H., Kim C.R., Kerr B., Ngai W.S., Yuen J.C.H. and Lai C.L., Phase I/II double-blind, randomized, placebo-controlled study of the novel anti-HBV agent LB80380/ANA380 in patients with chronic HBV infection., 55th Annual Meeting of the American Association for the Study of Liver Diseases, Boston, USA 29 Oct-2 Nov 2004 (Published in Hepatology). 2004, 40 (4 Suppl 1): 172A.

Yuen R.M.F., Yuan H., Wong D.K.H., Yuen J.C.H., Wong R.W.M., Chan O.O., Wong B.C.Y., Lai K.C. and Lai C.L., Prognostic determinants for chronic hepatitis B in Asians: therapeutic implications., Gut. 2005, online.

Yuen R.M.F., Tanaka K., Mizokami M., Yuen J.C.H., Hui C.K., Wong D.K.H., Yuan H., Sum S.M., Chan O.O., Wong B.C.Y., Fan S.T. and Lai C.L., Role of hepatitis B virus genotypes Ba and C, core promoter and precore mutations on hepatocellular carcinoma: a case control study, Carcinogenesis. 2004, 25(9): 1593-1598.

Yuen R.M.F. and Lai C.L., Serological markers of liver cancer., Best Practice & Research, Clinical Gastroenterology. 2005, 19(1): 91-9.

Yuen R.M.F. and Lai C.L., Treatment for hepatitis B: a public health perspective., Journal of Clinical Gastroenterology. 2004, 38(10 Suppl): 134-5.

Yuen R.M.F. and Lai C.L., Treatment of chronic hepatitis B, Medical Progress. 2005, 32(7): 349-56.

Zhang L., Chen Z., Cao Y., Yu J., Li G., Yu W., Yin N., Mei S., Li L., Balfe P., He T., Ba L., Zhang F., Lin H.H., Yuen R.M.F., Lai C.L. and Ho D.D., Molecular Characterization of Human Immunodeficiency Virus Type 1 and Hepatitis C Virus in Paid Blood Donors and Injection Drug Users in China , Journal of Virology. 2004, 78: 13591-13599.

Researcher : Lai KC

List of Research Outputs

Hui C.K., Lai K.C., Wong R.W.M., Yuen R.M.F., Ng M.M.T., Chan C.K., Hu H.C., Cheung W.W., Lai C.L. and Wong B.C.Y., Outpatients Undergoing Therapeutic Endoscopic Retrograde Cholangiopancreatography: Six-hour Versus Overnight Observation , Journal of Gastroenterology and Hepatology. 2004, 19: 1163-1168.

Lai K.C., Hui W.M., Wong B.C.Y., Hu H.C., Chan O.O. and Lam S.K., Lansorprazole but not Rofecoxib reduced dyspeptic symptoms of patients on NSAIDS, Gastroenterology. 2005, 128(4 Suppl 2): A24.

Lai K.C., Small Bowel Imaging: Capsule Endoscopy & Double Lumen Enteroscopy , 9th Hong Kong Medical Forum. 2004.

Wong B.C.Y., Chan O.O., Wong K.W., Ching C.K., Wong R.W.M., Tam S., Lai K.C., Chan C.K., Yuen R.M.F. and Lam S.K., A pilot study of participation in faecal occult blood testing and screening colonoscopy after health education in Hong Kong, European Journal of Cancer Preview. 2005, 14(2): 181-184.

Wong R.W.M., Huang J., Xia H.H.X., Fung F.M.Y., Tong S.M., Cheung K.L., Ho Y.K., Lai K.C., Chan C.K., Chan O.O., Hui C.K., Lam S.K. and Wong B.C.Y., Low-dose rabeprazole, amoxicillin and metronidazole triple therapy for the treatment of Helicobacter pylori infection in Chinese patients , Journal of Gastroenterology and Hepatology. 2005, 20(6): 935-940.

Wong R.W.M., Lai K.C., Hui W.M., Hu H.C., Huang J., Wong Y.H., Xia H.H.X., Chan O.O., Lam S.K. and Wong B.C.Y., Pathophysiology of Gastroesophageal Reflux Diseases in ChineseRole of Transient Lower Esophageal Sphincter Relaxation and Esophageal Motor Dysfunction, American Journal of Gastroenterology. 2004, 99: 2088-2093.

Wong R.W.M., Xiao S.D., HU P.J., Wang W., Gu Q., Huang J., Xia H.H.X., WU S.M., LI C.J., CHEN M.H., CUI Y., Lai K.C., Hu H.C., Chan C.K., Lam S.K. and Wong B.C.Y., Standard treatment for Helicobacter pylori infection is suboptimal in non-ulcer dyspepsia compared to duodenal ulcer in Chinese, Alimentary Pharmacology and Therapeutics. 2005, 21: 73-81.

Wong W.M., Lai K.C., Lam K.F., Hui W.M., Huang J.Q., Xia H.H.X., Hu H.C., Lam C.L.K., Chan C.K., Lam S.K. and Wong B.C.Y., Onset and disappearance of Reflux Symptoms in a Chinese population: a one-year follow-up study, Alimentary Pharmacology and Therapeutics. 2004, 20: 803-812.

Xia B., Xia H.H.X., Lam S.K., Chan O.O., Lai K.C., Hu H.C. and Wong B.C.Y., Trends in prevalence of peptic ulcer disease and Helicobacter pylori infection and frequency of NSAID intake in general practitioner-referred dyspeptic patients over 6 years in Hong Kong, Gastroenterology. 2005, 128(4 Suppl 2): A230.

Yuen R.M.F., Yuan H., Wong D.K.H., Yuen J.C.H., Wong R.W.M., Chan O.O., Wong B.C.Y., Lai K.C. and Lai C.L., Prognostic determinants for chronic hepatitis B in Asians: therapeutic implications., Gut. 2005, online.

Researcher : Lai KN

Project Title:	Establishment of immortalized B-lymphocyte cell lines for subsequent development of monoclonal antibodies against SARS-associated Coronavirus with clinical application in early diagnosis and future treatment
Investigator(s):	Lai KN, Kwong YL, Tsang KWT
Department:	Medicine
Source(s) of Funding:	VCO SARS Research Fund
Start Date:	07/2003

Abstract:

To explore the therapeutic value of these monoclonal antibodies as an adjuvant immuno-modulating therapy.

Project Title:	Development of monoclonal antibodies against SARS-associated coronavirus: specific targeting for early diagnosis and future treatment
Investigator(s):	Lai KN, Kwong YL, Chung SSM, Tsang KWT, Tam J.S.L.
Department:	Medicine
Source(s) of Funding:	Competitive Earmarked Research Grants (Special Grants for Severe Acute Respiratory Syndrome Research)
Start Date:	08/2003
Completion Date:	08/2004

Abstract:

To produce immortal B lymphocyte clones from these subjects recovering from SARS; to develop specific hybridomas from these human immortalized B lymphocytes that produce antibodies against SARS-related coronavirus; to determine the specificities of different monoclonal antibodies from the hybridomas against different protein components of the virus; to determine the application of these monoclonal antibodies for rapid diagnosis by using serum and/or tissue collected from patients at different stages of their illness; to explore the therapeutic value of these monoclonal antibodies as an adjuvant immuno-modulating therapy.

Project Title:	Chemokine production and T cell interaction in chronic glomerulo-nephritides and interstitial nephritis: exploration of tubulo-glomerular communication
Investigator(s):	Lai KN, Leung JCK, Tang S.C.W.
Department:	Medicine
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	10/2003

Abstract:

To study tubulo-glomerular crosstalk in the presence of proteinuria. Activated PTEC induce proliferation and matrix formation in mesangial cells via soluble factors (alone or with participation of infiltrating T cells/monocytes); to determine whether PTEC may undergo epithelial-mesenchymal transidfferentiation under the influence of glomerulopathic proteins (alone or with participation of infiltrating T cells/monocytes); to examine whether activated mesangial cells (HMC) induce tubular expression of proinflammatory mediators (complement, chemokine, and growth factor) and the subsequent development of tubular epithelial-mesenchymal transdifferentiation via soluble factors (alone or with participation of infiltrating T cells/monocytes).

Project Title:	Chemokine production and T cell interaction in chronic glomerulo-nephritides and interstitial nephritis: exploration of tubulo-glomerular communication
Investigator(s):	Lai KN, Leung JCK, Tang S.C.W.
Department:	Medicine
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	10/2003

Abstract:

Project Title:	The role of the renin-angiotensin system in the tubulointerstitial injury of IgA nephropathy (IgAN)
Investigator(s):	Lai KN, Leung JCK
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2004

Abstract:

To define the role of RAS in inducing PTEC/MC damage and; to elucidate the cross-talk between resident cells and infiltrating cells (T-cells/monocytes).

Project Title:	The role of the renin-angiotensin system in the tubulointerstitial injury of IgA nephropathy (IgAN)
Investigator(s):	Lai KN, Leung JCK
Department:	Medicine
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	01/2005

Abstract:

To determine whether there are known IgA receptors in the renal tubules; to determine the presence of any specific binding of pIgA from patients with IgAN to renal tubular epithelial cells; if there is no specific binding of IgA from IgAN to renal tubular epithelial cells, to find out where there are humoral or soluble factors from activated mesangial cells that induce tubular expression of proinflammatory mediators and the subsequent development of tubular epithelial-mesenchymal transdifferentiation; to explore which receptors for these proinflammatory mediators are present in renal tubules; to find out whether tubular damage is mediated via soluble factors alone or infiltrating T-cells/monocytes are also required.

Project Title:	The role of the renin-angiotensin system in the tubulointerstitial injury of IgA nephropathy (IgAN)
Investigator(s):	Lai KN
Department:	Medicine
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

Refer to hard copy

List of Research Outputs

Chan D.T.M., Tse K.C., Tang C.S.O., Lai K.N. and Li F.K., Long-term outcome of patients with diffuse proliferative lupus nephritis treated with prednisolone and oral cyclophosphamide followed by azathioprine. , Lupus. 2005, 14(4): 265-272.

Chan D.T.M., Tse K.C., Tang C.S.O., Lai K.N. and Ho S.K.N., Prospective study on lamivudine-resistant hepatitis B in renal allograft recipients, American Journal of Transplantation. 2004, 4(7): 1103-1109.

Chan G.S.W., Lam M.F., Au W.Y., Tse K.C., Chan D.T.M., Lai K.N. and Chan K.W., IgA nephropathy complicating graft-versus-host disease, another nephropathy causing nephrotic syndrome after bone marrow transplantation, Histopathology. 2004, 45(6): 648-651.

Chan L.Y., Leung J.C.K., Tsang W.L., Tang S.C.W. and Lai K.N., Activation of tubular epithelial cells by mesangial-derived TNF-alpha: glomerulotubular communication in IgA nephropathy , Kidney International. 2005, 67: 602-612.

Chan L.Y., Leung J.C.K. and Lai K.N., Novel mechanisms of tubulointerstitial injury in IgA nephropathy: a new therapeutic paradigm in the prevention of progressive renal failure, Clinical and Experimental Nephrology . 2004, 8: 297-303.

Chu K.H., Tsang W.K., Tang C.S.O., Lam M.F., Lai F.M., To K.F., Fung K.S., Tang H.L., Yan W.W., Chan H.W.H., Lai T.S.T., Tong K.L. and Lai K.N., Acute renal impairment in coronavirus-associated severe acute respiratory syndrome, Kidney International. 2005, 67: 698-705.

Lai K.N., Associate Editor, American Journal of Kidney Diseases. 2004.

Lai K.N., Clinical and pathologic aspects of IgA diseases, International Society of Nephrology - 3rd World Congress of Nephrology, Singapore, June 26-29, 2005. 2005.

Lai K.N., Leung J.C.K., Chan L.Y., Li F.K., Tang S.C.W., Lam M.F., Tse K.C., Yip T., Chan D.T.M., Wieslander A. and Vlassara H., Differential expression of receptors for advanced glycation end-products in peritoneal mesothelial cells exposed to glucose degradation products, Clinical and Experimental Immunology. 2004, 138: 466-475.

Lai K.N., Chan L.Y., Tsang W.L., Tang S.C.W. and Leung J.C.K., Differential regulation of AT1 and AT2 receptors by angiotensin II in human mesangial and renal proximal tubular epithelial cells, Journal of American Society of Nephrology. 2004, 15: 841A.

Lai K.N., Hepatitis C virus and renal diseases, International Conference on Treatment of Glomerular Diseases - Nanjing University and People's Liberation Army Medical Institute, China, September 24-27, 2004. 2004.

Lai K.N., Infection associated glomerulonephritis, International Society of Nephrology - 3rd World Congress of Nephrology, Singapore, June 26-29, 2005. 2005.

Lai K.N., Is there evidence of treatment of hepatitis C-related cryoglobulinemic glomerulonephritis?, International Society of Nephrology - 3rd World Congress of Nephrology, Singapore, June 26-29, 2005. 2005.

Lai K.N., Managing Editor, Section of Experimental Nephrology, Nephrology [Blackwell] . 2004.

Lai K.N., Chan L.Y. and Leung J.C.K., Mechanisms of tubulointerstitial injury in IgA nephropathy, Kidney International. 2005, 67(suppl 94): S110-S115.

Lai K.N., Member of the Editorial Board, Chinese Journal of Nephrology. 2004.

Lai K.N., Member of the Editorial Board, Dialysis and Transplantation. 2004.

Lai K.N., Mesangial IgA deposition in IgA nephropathy - what next?, 9th Research Forum on Progressive Renal Diseases, Nagoya, Japan, February 12, 2005. 2005.

Lai K.N., Mesangial IgA deposition in IgA nephropathy - what next?, International Conference on Treatment of Glomerular Diseases - Nanjing University and People's Liberation Army Medical Institute, China, September 24-27, 2004. 2004.

Lai K.N., Chan L.Y., Tang S.C.W., Tsang W.L., Li F.K., Lam M.F., Lui S.L. and Leung J.C.K., Mesangial expression of angiotensin II receptor in IgA nephropathy and its regulation by polymeric IgA1 , Kidney International. 2004, 66: 1403-1416.

Lai K.N., Renal issues in severe acute respiratory syndrome (SARS), Annual Scientific Meeting of the Korean Society of Nephrology, Seoul, Korea, May 20-21, 2005. 2005.

Lai K.N., The renin-angiotensin system in IgA nephropathy, Annual Scientific Meeting of the Korean Society of Nephrology, Seoul, Korea, May 20-21, 2005. 2005.

Lai K.N., Mok C.C. and Tang S.C.W., Treatment for lupus nephritis: a revisit , Nephrology. 2005, 10: 180-188.

Lai K.N., Tang S.C.W., Tsang W.L., Chan L.Y. and Leung J.C.K., Ganaderma extract prevents albumin-induced oxidative damage and chemokine synthesis in cultured human proximal tubular epithelial cells, Journal of American Society of Nephrology. 2004, 15: 107A.

Lam M.F., Yip P.S., Leung J.C.K., Chan D.T.M., Lo W.K. and Lai K.N., Mannose binding lectin gene mutation and incidence rate of peritonitis in long-term peritoneal dialysis patients, Journal of American Society of Nephrology. 2004, 15: 598A.

Lam M.F., Lo W.K., Chu F.S., Li F.K., Yip T.P., Tse K.C., Chan D.T.M. and Lai K.N., Retroperitoneal leakage as a cause of ultrafiltration failure, Peritoneal Dialysis International. 2004, 24(5): 466-470.

Lam M.F., Yip T.P.S., Tse K.C., Li F.K., Lui S.L., Lai K.N. and Chan D.T.M., Sirolimus in kidney transplantation: a pilot study in Chinese patients, Hong Kong Journal of Nephrology. Hong Kong, 2004, 6(1): 38-42.

Leung J.C.K., Chan L.Y., Tsang W.L., Tang S.C.W. and Lai K.N., Anti-macrophage migration inhibitory factor reduces transforming growth factor-beta 1 expression in experimental IgA nephropathy, Nephrology Dialysis Transplantation. 2004, 19: 1976-1985.

Leung J.C.K., Chan L.Y., Tsang W.L., Guo H., Tang S.C.W., Chan D.T.M. and Lai K.N., Differential expression of aquaporins in the kidneys of streptozotocin-induced diabetic mice , Nephrology. 2005, 10: 63-72.

Leung J.C.K., Chan Y.Y., Li F.K., Tang S.C.W., Chan K.W., Chan D.T.M., Lam M.F., Wieslander A. and Lai K.N., Glucose degradation products downregulate ZO-1 expression in human peritoneal mesothelial cells: the role of VEGF, Nephrology Dialysis Transplantation. 2005, 20(7): 1336-1349.

Leung J.C.K., Chan L.Y., Tsang W.L., Tang S.C.W. and Lai K.N., Increased synthesis of TNF-a and IL-6 by mesangial cells cultured with polymeric anionic IgA from patients with IgA nephropathy, Journal of American Society of Nephrology. 2004, 15: 224A.

Li F.K., Lam M.F., Yip P.S., Chan D.T.M. and Lai K.N., Refractory fluid overload in CAPD patients: management strategies and outcomes, Journal of American Society of Nephrology. 2004, 15: 637A.

Li P.K., Weening J.J., Dirks J., Lui S.L., Szeto C.C., Tang S.C.W., Atkins R.C., Mitch W.E., Chow K.M., D'Amico G., Freedman B.I., Harris D.C., Hooi L.S., Jong P.E., Kincaid-Smith P. and Lai K.N., A report with consensus statements of the International Society of Nephrology 2004 Consensus Workshop on Prevention of Progression of Renal Disease, Hong Kong, June 29, 2004 , Kidney International. 2005, 67(suppl 94): S2-S7.

Li Y.J., Du Y., Li C.X., Guo H., Leung J.C.K., Lam M.F., Yang N., Huang F., Chen Y., Feng J.Q., Maxwell P.H., Lai K.N. and Wang Y., Family-based association study showing that immunoglobulin A nephropathy is associated with the polymorphisms 2093C and 2180T in the 3' untranslated region of the Megsin gene , Journal of American Society of Nephrology. 2004, 15: 1739-1747.

Lo W.K., Lui S.L., Chan D.T.M., Li F.K., Lam M.F., Tse K.C., Tang C.S.O., Choy C.B.Y. and Lai K.N., Minimal and optimal peritoneal Kt/V targets: results of an anuric peritoneal dialysis patient's survival analysis. , Kidney International. 2005, 67(5): 2032-2038.

Lui S.L., Cheng S.W., Ng E., Yip P.S., Tse K.C., Lam M.F., Lai K.N. and Lo W.K., A randomized prospective comparison of intraperitoneal cefazolin plus netilimicin versus cefazolin plus ceftazidime in the treatment of CAPD peritonitis, Nephrology Dialysis Transplantation. 2005, 10 (suppl): A68.

Lui S.L., Chan D.T.M. and Lai K.N., Au update on immunosuppressive drugs for renal transplantation, Medical Progress. Hong Kong, 2005, 32(2): 57-63.

Lui S.L., Wong R.W.M., Ng S.Y., Chan D.T.M., Lai K.N. and Lo W.K., Seroprevalence of Helicobacter pylori in Chinese patients on continuous ambulatory peritoneal dialysis , Nephrology. 2005, 10(1): 21-24.

Lui S.L., Yip P.S., Tse K.C., Lam M.F., Li F.K., Lai K.N. and Lo W.K., Simultaneous removal and reinsertion of peritoneal dialysis catheters for the treatment of refractory pseudomonas exit site infection in CAPD patients, Nephrology. 2005, 10(suppl): A68.

Lui S.L., Tang S., Li F.K., Choy C.B.Y., Chan D.T.M., Lo W.K. and Lai K.N., Tuberculous infection in southern Chinese renal transplant recipients, Clinical transplantation. 2004, 18(6): 666-671.

Tang S.C.W., Leung J.C.K., Chan L.Y., Tsang W.L. and Lai K.N., Albumin-induced interleukin-8 expression in renal tubular cells is abrogated by angiotensin type 2 but not type 1 receptor blockade, Journal of American Society of Nephrology. 2004, 15: 847A.

Tang S.C.W., Tse K.C., Chan K.W., Ho Y.W. and Lai K.N., Anderson-Fabry disease, American Journal of Kidney Diseases. 2005, 45: A51, e21-22.

Tang S.C.W. and Lai K.N., Chronic viral hepatitis in hemodialysis patients, Hemodialysis Internatoinal. 2005, 9: 169-179.

Tang S.C.W., Ho Y.W., Leung V.K., Leung C.Y., Chan D.T.M. and Lai K.N., Lamivudine improves renal outcome in hepatitis-B related membranous nephropathy, Journal of American Society of Nephrology. 2004, 15: 341A.

Tang S.C.W., Ho Y.W., Tang A., Cheng A., Lam W.N. and Lai K.N., Late initiation of dialysis adversely affects short-term outcome in peritoneal dialysis subjects, Nephrology. 2005, 10(suppl): A76.

Tang S.C.W., Lui S.L. and Lai K.N., Pathogenesis of lupus nephritis: an update , Nephrology. 2005, 10: 174-179.

Tang S.C.W. and Lai K.N., Posttransplantation lymphoproliferative disorder (PTLD) involving the brain and the allograft, American Journal of Kidney Diseases. 2005, 45: A55, e61-2.

Tang S.C.W., Leung W.S., Chan V., Chu C.M., Lam B., Leung H., Lam W.O., Ho Y.W., Chan D.T.M. and Lai K.N., Sleep apnea in patients undergoing nocturnal peritoneal dialysis., Peritoneal Dialysis International. 2004, 24 (S2): S49.

Tang S.C.W. and Lai K.N., Ultrasound-guided biopsy of native and transplanted kidneys., Saudi Journal of Kideny Diseases and Transplantation. 2004, 15: 300-304.

Researcher : Lai MH

List of Research Outputs

Kung A.W.C., Lai M.H., Lau H.L. and Chan V.N.Y., Polymorphisms in the promoter region of the estrogen receptor beta gene are associated with higher risks of osteoporosis in both men and women, Osteoporosis Global Conference, 2nd Joint Meeting of European Calcified Tissue and International Bone & Mineral Society, 25-29 June 2005, Geneva, Switzerland. 2005.

Lai M.H., Lau H.L., Chan V.N.Y. and Kung A.W.C., Estrogen receptor beta gene polymorphisms in the promoter region are associated with higher risks of osteoporosis in both men and women, The Endocrine Society’s 87th Annual Meeting, June 4-7, 2005, San Diego, USA. 2005.

Lai M.H., Lau H.L., Chan V.N.Y. and Kung A.W.C., Polymorphisms in the promoter region of the estrogen receptor beta gene are associated with higher risks of osteoporosis in both men and women, HKU 10th Medical Research Conference. 2005.

Lai M.H., Lau H.L., Chan V.N.Y. and Kung A.W.C., Promoter polymorphisms of the estrogen receptor beta gene are associated with higher risks of osteoporosis in both men and women, 6th Regional Osteoporosis Conference, 21-22 May 2005, Hong Kong. 2005.

Researcher : Lai TST

List of Research Outputs

Chu K.H., Tsang W.K., Tang C.S.O., Lam M.F., Lai F.M., To K.F., Fung K.S., Tang H.L., Yan W.W., Chan H.W.H., Lai T.S.T., Tong K.L. and Lai K.N., Acute renal impairment in coronavirus-associated severe acute respiratory syndrome, Kidney International. 2005, 67: 698-705.

Researcher : Lam B

List of Research Outputs

Ho J.C.M., Wu A.Y.Y., Lam B., Ooi C.G.C., Khong P.L., Ho P.L., Chan M.M.W., Zhong N.S., Ko K.W., Lam W.K. and Tsang K.W.T., Pentaglobin in steroid-resistant severe acute respiratory syndrome, International Journal of Tuberculosis and Lung Disease. 2004, 8(10): 1173-1179.

Ip M.S.M., Tse H.F. and Lam B., Rebuttal to "vascular dysfunction may be mediated by other mechanisms", American Journal of Respiratory and Critical Care Medicine. 2004, 170: 197-198.

Lam B., Sam K., Mok W.Y.W., Lam J.C., Yam L.Y.C., Lam W.K. and Ip M.S.M., A randomized study of three non-surgical treatment options in mild to moderate obstructive sleep apnea, American Thoracic Society International Conference, San Diego, USA. May 2005. Proceedings of the American Thoracic Society. 2005, p.A303.

Lam B., Ip M.S.M., Tench E. and Ryan C.F., Cranofacial profile in Asian and while subjects with obstructive sleep apnoea, Thorax. 2005, 60(6): 504-510.

Lam B., Detection of Early Lung Cancer by Fluorescence Bronchoscopy , 9th Hong Kong Medical Forum. 2004.

Lam B., Tam C.M., Lam S.Y., Wong M.P., Ooi C.G.C., Fung S.L., Ip M.S.M. and Lam W.K., Detection of early lung cancer in high risk population : a prospective study, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A122.

Lam J.C.M., Ooi C.G.C., Tam S., Khong P.L., Lam B. and Ip M.S.M., Obesity and dyslipidemia in Chinese patients with obstructive sleep apnea, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A143.

Lam W.K., Ho J.C.M., Lam B. and Tsang K.W.T., SARS and impacts on travel, Textbook of Travel Medicine . Bangkok Press, Bangkok, 2004, Chapter 38: 405-414.

Tan K.C.B., Chow W.S., Lam J.C.M., Lam B., Wong W.K., Tam S. and Ip M.S.M., HDL dysfunction in obstructive sleep apnea, Atherosclerosis. 2005-02-01, 2005, Epub ahead of print.

Tang S.C.W., Leung W.S., Chan V., Chu C.M., Lam B., Leung H., Lam W.O., Ho Y.W., Chan D.T.M. and Lai K.N., Sleep apnea in patients undergoing nocturnal peritoneal dialysis., Peritoneal Dialysis International. 2004, 24 (S2): S49.

Wang J., Law K.W., Ip M.S.M., Wu A.Y.Y., Wong M.K., Lam B., Chow K.M. and Chan M.M.W., Effect of asthma self management programme on asthma morbidity and health care utilization in adult patients admitted to hospital with acute asthma in Hong Kong: A randomized controlled trial, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A91.

Researcher : Lam CLK

List of Research Outputs

Beasley J.W., Dovey S., Geffen L.N., Gomez-Clavelina F.J., Haq C.L., Inem V., Lam C.L.K., Nugmanova A., Pavlic D.R., Qidwai W. and Van Weel C., The contribution of family doctors to primary care research: a global perspective from the International Federation of Primary Care Research Networks (IFPCRN), Primary Health Care Research and Development. 2004, 5: 307-316.

Lam C.L.K., Tse E.Y.Y. and Gandek B., Is the standard SF-12 Health Survey valid and equivalent for a Chinese population?, Quality of Life Research. 2005, 14(2): 539-547.

Lam C.L.K., Lecture on 'Potential Research Areas in Family Medicine', Joint Research Meeting, Department of Community and Family Medicine, Chinese University of Hong Kong and Family Medicine Unit, the University of Hong Kong. Hong Kong, 2005.

Lam C.L.K., Lecture on Family Medicine Training in Hong Kong, 中?????全科??分?/香港家庭???院?? 中?深圳全?全科?生骨干短期培?班, Hong Kong, 2004.

Lam C.L.K., Lecture on ‘Potential Research Areas in Family Medicine’. , Joint Research Meeting, Department of Community and Family Medicine, Chinese University of Hong Kong and Family Medicine Unit, the University of Hong Kong. Hong Kong.. 2005.

Lam C.L.K., Paper on 'Pilot Test of the SF-6D Valuation Survey on Chinese Adults in Hong Kong', The 11th Annual Conference of the International Society for Quality of Life Research. Hong Kong, 2004.

Lam C.L.K., Paper on 'Risk Factors and Impact of Subclinical Psychological Problems of the Elderly in Primary Care', 10th Medical Research Conference. Department of Medicine, the University of Hong Kong. Hong Kong, 2005.

Lam C.L.K., Brazier J. and McGhee S.M., Pilot test of SF-6D valuation survey on Chinese adults in Hong Kong (abstract), Quality of Life Research. 2004, 13: 1509.

Lam C.L.K., Plenary Lecture on 'Family Medicine Meeting Dentistry in Primary Care', Oral Health Symposium, the University of Hong Kong. Hong Kong, 2005.

Lam C.L.K., Seminar on 'Introduction to Medical Research', Diploma in Family Medicine Course, Hong Kong College of Family Physicians. 2005.

Lam C.L.K., Seminar on “ An Introduction to Family Therapy”. , CME programme, Hong Kong Academy of Medicine. Pamela Youde Eastern Nethersole Hospital, Hong Kong. . 2005.

Lam C.L.K., The contributions of family medicine research, The Hong Kong Practitioner. Hong Kong, 2005, 27: 169-170.

Lam C.L.K., Workshop on 'Principles of Research - Qualitative or Quantitative?' , Professional Development and Quality Assurance Centre, Department of Health. Hong Kong, 2004.

Lam C.L.K., Workshop on Consultation Skills in Family Medicine, 中?????全科??分?/香港家庭???院??全?高?全科?學??培訓班. Capital University, Beijing, China, 2005.

Lam C.L.K., Workshop on Consultation Skills in Family Medicine, 中?????全科??分?/香港家庭???院?? 中?深圳全?全科?生骨干短期培?班, Shenzhen, China, 2004.

Lam C.L.K., Workshop on the Management of Common Problems and Chronic Problems in Family Medicine, 中?????全科??分?/香港家庭???院??全?高?全科?學??培訓班. Capital University, Beijing, China, 2005.

Lam C.L.K., Workshop on the Principles and Concepts of Family Medicine, 中?????全科??分?/香港家庭???院??全?高?全科?學??培訓班. Capital University, Beijing, China, 2005.

Lam C.L.K., Workshop on the Principles and Concepts of Family Medicine, 中?????全科??分?/香港家庭???院?? 中?深圳全?全科?生骨干短期培?班, Shenzhen, China, 2004.

Mok W.Y.W., Lam C.L.K., Lam B., Cheung M.T., Yam L. and Ip M.S.M., A Chinese version of the Sleep Apnea Quality of Life Index was evaluated for reliability, validity and responsiveness, Journal of Clinical Epidemiology. 2004, 57: 470-478.

Sin P.Y., Tse H.F., Siu C.W., Tsang V.Y.C., Lam C.L.K. and Lau C.P., Impairment of quality-of-life in patients with atrial fibrillation. In Tse HF, Tse TF, Lau CP, Woo KS(eds), First Global Conference on Cardiovascular Clinical Trials and Pharmacotherapy - 2nd WHF Global Conference on Cardiovascular Clinical Trials and 13th International Society of Cardiovascular Pharmacotherapy Congress. Italy, Monduzzi Editore, 2005, 45-50.

Sin P.Y., Tse H.F., Siu C.W., Tsang V.Y.C., Lam C.L.K. and Lau C.P., Successful pulmonary vein isolation using transvenous catheter cryoablation improves quality-of-life in patients with atrial fibrillation. In Tse HF, Tse TF, Lau CP, Woo KS (eds):, First Global Conference on Cardiovascular Clinical Trials and Pharmacotherapy - 2nd WHF Global Conference on Cardiovascular Clinical Trials and 13th International Society of Cardiovascular Pharmacotherapy Congress. Italy, Monduzzi Editore, 2005, 51-56.

Tse H.F., Tsang V.Y.C., Lam C.L.K., Lau C.P., Sin P.Y. and Siu C.W., Successful pulmonary vein isolation using transvenous catheter cryoablation improves quality-of-life in patients with atrial fibrillation, Pacing Clin Electrophysiol. 2005, 28(5): 421-4.

Wong J.G.W.S., Cheung E.P.T., Chen E.Y.H., Chan R.C.K., Law C.W., Lo M.S.M., Leung K.F. and Lam C.L.K., An instrument to assess mental patients' capacity to appraise and report subjective quality of life, Quality of Life Research. 2005, 14: 687-694.

Wong W.M., Lai K.C., Lam K.F., Hui W.M., Huang J.Q., Xia H.H.X., Hu H.C., Lam C.L.K., Chan C.K., Lam S.K. and Wong B.C.Y., Onset and disappearance of Reflux Symptoms in a Chinese population: a one-year follow-up study, Alimentary Pharmacology and Therapeutics. 2004, 20: 803-812.

Researcher : Lam CW

List of Research Outputs

Chan K.W., Xu A., Hoo R.L.C., Tan K.C.B., Zhang J., Lam C.W. and Lam K.S.L., Selective Reduction of the High Molecular Weight Form of Adiponectin by Testosterone: A Potential Mechanism That Underlies the Sexual Dimorphism of Adiponectin Oligomeric Distribution, The Endocrine Society’s 87th Annual Meeting, June 4-7, 2005, San Diego, USA. 2005.

Chan K.W., Xu A., Hoo R.L.C., Lam C.W. and Lam K.S.L., Sexual dimorphism of adiponectin: Why do men have higher risk to diabetes and atherosclerosis than women?, 10th Medical Research Conference, The University of Hong Kong. 19-20 Feb 2005. Endocrinology 24.

Chen B., Xu A., Lam C.W., Hoo R.L.C. and Lam K.S.L., Adenovirus-mediated expression of adiponectin alleviates liver fibrosis and induces apoptosis of activated hepatic stellate cells, 10th Medical Research Conference, The University of Hong Kong. 19-20 Feb 2005. Endocrinology 23.

Hoo R.L.C., Xu A., Lam C.W., Chen B., Carling D. and Lam K.S.L., Adenovirus-mediated expression of constitutively active AMP-activated protein kinase alleviates diabetes in db/db diabetic mice, 10th Medical Research Conference, The University of Hong Kong. 19-20 Feb 2005. Endocrinology 25.

Xu A., Hoo R.L.C., Hoo R.L.C., Lam C.W., Chen B. and Lam K.S.L., Adenovirus-Mediated Expression of Adiponectin Alleviates Endothelial Dysfunction and Oxidative Stress Associated with db/db Diabetic Mice, The Endocrine Society’s 87th Annual Meeting, June 4-7, 2005, San Diego, USA. 2005.

Xu A., Lam C.W., Chan K.W., Zhang J., Hoo R.L.C., Xu J., Chen B. and Lam K.S.L., Angiopoietin-like protein 4 is a novel metabolic hormone with therapeutic potentials for hyperglycemia and insulin resistance, 10th Medical Research Conference, The University of Hong Kong. 19-20 Feb 2005. Endocrinology 22.

Researcher : Lam KSL

Project Title:	Genetic and hormonal influences on phenotypic expression of apolipoprotein (a)
Investigator(s):	Lam KSL
Department:	Medicine
Source(s) of Funding:	Outstanding RGC Projects
Start Date:	11/1998

Abstract:

To enhance research level.

Project Title:	The role of aldose reductase in the pathogenesis of diabetic nephropathy and atherosclerosis: interaction of polyol pathway with non-enzymatic glycation
Investigator(s):	Lam KSL, Dan Q
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002
Completion Date:	10/2004

Abstract:

To demonstrate whether aldose reductase (AR) is involved in the pathogenesis of diabetic nephropathy and atherosclerosis; to explore the interaction between polyol pathway and non-enzymatic glycation in the development of (a) diabetic nephropathy and (b) diabetic atherosclerosis.

Project Title:	Clinical, genetic and functional studies of two novel fat-derived hormones
Investigator(s):	Lam KSL, Wat NMS, Xu A
Department:	Medicine
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	08/2003

Abstract:

To conduct a systematic analysis of the polymorphisms and mutations in the resistin and adiponectin genes in Southern Chinese and to investigate, in cross-sectional and prospective studies, their association with insulin resistance and related disorders including obesity, impaired glucose tolerance, type 2 diabetes, hypertension, dyslipidaemia and carotid atherosclerosis; to determine the relationship of serum resistin to indices of insulin resistance in population studies; to investigate whether circulating adiponectin levels and isoforms, and resistin levels are genetically determined, whether they are predictive of the development of diabetes and hypertension in a 5-year prospective study, and whether they are associated with the development of carotid atherosclerosis; to examine the relationship of circulating adiponectin and resistin to other causes of insulin resistance including age, growth hormone excess and presence of chronic systemic inflammation; to elucidate how the genetic mutations/polymorphisms lead to altered expression and/or functions of resistin and adiponectin using site-directed mutagenesis and functional studies. To investigate whether circulating adiponectin and resistin levels are genetically determined, whether they are predictive of the development of diabetes and hypertension in a 5-year prospective study, and whether they are associated with the development of carotid atherosclerosis.

Project Title:	Clinical, genetic and functional studies of two novel fat-derived hormones
Investigator(s):	Lam KSL, Wat NMS, Xu A
Department:	Medicine
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	08/2003

Abstract:

Project Title:	Adiponectin as a novel diagnostic marker and therapeutic target for the treatment of diabetes, steatohepatitis and other metabolic disorders
Investigator(s):	Lam KSL, Xu A, Shen J, Chao Y.S.
Department:	Medicine
Source(s) of Funding:	Innovation and Technology Support Programme
Start Date:	11/2003

Abstract:

To develop, standardize and evaluate an ultra sensitive and rapid adiponectin assay kit for prognostic assessment of these metabolic disorders in obese populations, for selecting the most effective therapeutic drugs for patients with these health problems; and for monitoring their response to tailored treatment; to use our recently established high-throughout adiponectin promoter assay system to screen for novel drugs from tradtional Chinese medicine and other chemical libraries that can enhance the production of the subject's endogenous adiponectin, which can be used for the treatment of the Metabolic Syndrome (type 2 diabetes, dyslipidemia, fatty liver and atherosclerosis), alcoholic liver injury, and metabolic disorders associated with treatment for HIV infections.

Project Title:	Autocrine functions of adipokines
Investigator(s):	Lam KSL, Xu J, Xu A
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Abstract:

To establish a system to stably and efficiently suppress the expression of resistin, adiponectin and adipocyspin in mouse adipocytes using RNA interference; to investigate the autocrine function of these adipolines on adipogenesis, lipolysis, lipogenesis and insulin sensitivity in the gene-knock down cell models.

Project Title:	Linking the metabolic syndrome with progressive atherosclerosis: role of fat-derived hormones
Investigator(s):	Lam KSL, Chau MT, Wat NMS, Xu A
Department:	Medicine
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2004

Abstract:

To determine whether serum levels of adiponectin are predictive of progressive atherosclerosis in man in a 5-year prospective study; to establish a sensitive ELISA method for accurate quantification of human PGAR and investigate the relationship of serum PGAR levels with obesity, insulin resistance, glucose tolerance, blood pressure, lipid levels and progression in carotid atherosclerosis; to investigate the effects of adenovirus-mediated chronic administration of adiponectin or PGAR on glucose and lipid metabolism, and development of atherosclerosis in db/db mice, an animal model of the metabolic syndrome.

Project Title:	Adiponectin as a novel diagnostic marker and therapeutic target for the treatment of diabetes, steatohepatitis and other metabolic disorders
Investigator(s):	Lam KSL
Department:	Medicine
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	11/2004
Completion Date:	10/2005

Abstract:

Refer to hard copy

Project Title:	Linking the metabolic syndrome with progressive atherosclerosis: role of fat-derived hormones
Investigator(s):	Lam KSL
Department:	Medicine
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

Refer to hard copy

Project Title:	Application for seed fund for the strategic theme on healthy ageing
Investigator(s):	Lam KSL, Che CM, Lee TMC, Lee WWM, McMillan AS, Chen SF
Department:	Medicine
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	05/2005

Abstract:

To integrate the existing strengths in aging related research within HKU through the identification of important themes of common interest; to provide core platforms for interdisciplinary research on aging diseases; to develop novel therapeutic approaches for the promotion of healthy aging.

List of Research Outputs

Chan K.W., Xu A., Hoo R.L.C., Tan K.C.B., Zhang J., Lam C.W. and Lam K.S.L., Selective Reduction of the High Molecular Weight Form of Adiponectin by Testosterone: A Potential Mechanism That Underlies the Sexual Dimorphism of Adiponectin Oligomeric Distribution, The Endocrine Society’s 87th Annual Meeting, June 4-7, 2005, San Diego, USA. 2005.

Chan K.W., Xu A., Hoo R.L.C., Lam C.W. and Lam K.S.L., Sexual dimorphism of adiponectin: Why do men have higher risk to diabetes and atherosclerosis than women?, 10th Medical Research Conference, The University of Hong Kong. 19-20 Feb 2005. Endocrinology 24.

Chang A., Chan W.F., Lo C.Y. and Lam K.S.L., Multiple endocrine neoplasia type 2 in Chinese families, Hong Kong Medical Journal. 2004, 10: 206-9.

Chen B., Xu A., Lam C.W., Hoo R.L.C. and Lam K.S.L., Adenovirus-mediated expression of adiponectin alleviates liver fibrosis and induces apoptosis of activated hepatic stellate cells, 10th Medical Research Conference, The University of Hong Kong. 19-20 Feb 2005. Endocrinology 23.

Cheung B.M.Y., Lam T.H., Lam K.S.L., Tam S., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Man Y.B., Cheng C.H., Kumana C.R. and Lau C.P., Follow Up of the Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., High Blood Pressure is Related to Obesity in Hong Kong, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Lipid Profile of the Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Obesity in the Hong Kong Cardiovascular Risk Factor Prevalence Survey-2 (CRISPS2) Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of Diabetes Mellitus (DM) in the Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Wat N.M.S., Lo L.F., Chau F.Y., Lam T.H., Leung G.M., Tam S., Cheng C.H., Kumana C.R., Lau C.P. and Lam K.S.L., Prevalence of Hypertension in Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort, J Hong Kong Coll Cardiol. 2004, 12: 33.

Cheung B.M.Y., Lo L.F., Fong D.Y.T., Chan M.Y., Wong W.H.S., Lau C.P., Lam K.S.L., Wong V.C.N. and Karlberg J.P.E., Randomised Controlled Trial of Qigong in Hypertension, Cardiovasc Drugs Thera. 2004, 28 (suppl) 1: 28.

Cheung B.M.Y., Lo L.F., Fong D.Y.T., Chan M.Y., Wong W.H.S., Lau C.P., Lam K.S.L., Wong V.C.W. and Karlberg J.P.E., Randomised controlled trial of qigong in hypertension, J Hong Kong Coll Cardiol. 2004, 12: 34.

Cheung B.M.Y., Lo L.F., Fong D.Y.T., Chan M.Y., Wong S.H.T., Wong V.C.W., Lam K.S.L., Lau C.P. and Karlberg J.P.E., Randomised controlled trial of qigong in the treatment of mild essential hypertension, J Hum Hypertens. 2005, 19(9): 697-704.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Relationship Between Hypertension and Obesity in Hong Kong, 3rd Asian-Pacific Congress on Hypertension, Singapore 2004.

Cheung B.M.Y., Lam T.H., Lam K.S.L., Tam S., Wat N.M.S., Man Y.B., Cheng C.H., Kumana C.R. and Lau C.P., The Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort - Results at 7 Years, J Hypertens. 2004, 22 (Suppl 2): S268-269.

Cheung S.F., Lam K.S.L. and Chung S.K., An over-expressed endothelin-1 transgenic mouse model for diabetic retinopathy study (Oral presentation), 9th Research Postgraduate Symposium, Faculty of Medicine, The University of Hong Kong, Dec 4. 2004.

Cheung S.F., Lam K.S.L., So K.F., Chung S.S.M. and Chung S.K., Transgenic mice over-expressing endothelin-1 in endothelial cells have blood-retinal barrier breakdown and lower expression of glial fibrillary acidic protein (Poster presentation), The Hong Kong Society of Neurosciences, the 24th Annual Scientific Meeting, Jan 13-14. 2005, 37 No. P-4.

Dan Q., Wong L.C., Chung S.K., Chung S.S.M. and Lam K.S.L., Interaction between the polyol pathway and non-enzymatic glycation on aortic smooth muscle cell migration and monocyte adhesion, Life Science. 2004, 76(4): 445-59.

Dan Q., Wong R.L.C., Yin S., Chung S.K., Chung S.S.M. and Lam K.S.L., Interaction between the polyol pathway and non-enzymatic glycation on mesangial cell gene expression, Nephron and Experimental Nephrology. 2004, 98: 89-99.

Hoo R.L.C., Xu A., Lam C.W., Chen B., Carling D. and Lam K.S.L., Adenovirus-mediated expression of constitutively active AMP-activated protein kinase alleviates diabetes in db/db diabetic mice, 10th Medical Research Conference, The University of Hong Kong. 19-20 Feb 2005. Endocrinology 25.

Ku C.F., Lo C.Y., Chan W.F., Chiu S.W., Fan S.T. and Lam K.S.L., Resection of phaeochromocytoma extending into the right atrium in a patient with multiple endocrine neoplasia type 2A, Hong Kong Medical Journal. 2005, 11(1): 59-62.

Ku C.F., Lo C.Y., Chan W.F., Kung A.W.C. and Lam K.S.L., Total thyroidectomy replaces subtotal thyroidectomy as the preferred surgical treatment for Graves' disease, ANZ Journal of Surgery. 2005, 75: 528-531.

Lam J.C., Ooi C.G.C., Tam S., Lam K.S.L. and Ip M.S.M., Insulin resistance and other cardiovascular risk factors in obstructive sleep apnea, American Thoracic Society International Conference, San Diego, USA. May 2005. Proceedings of the American Thoracic Society. 2005, p.A232.

Lam J.C., Lam K.S.L., Tam S., Lam C.L. and Ip M.S.M., The determinants of blood pressure in relation to obstructive sleep apnea, American Thoracic Society International Conference, San Diego, USA. May 2005. Proceedings of the American Thoracic Society. 2005, p.A878.

Lam J.C.M., Lam K.S.L., Tam S., Yan S.W. and Ip M.S.M., The determinants of blood pressure in relatin to obstructive sleep apnea, 10th Medical Research Conference, Department of Medicine, The University of Hong Kong, February 2005. Abstract Book: RM 58.

Lam J.C.M., Ooi C.G.C., Lam K.S.L., Tam S., Lai A.Y.K., Tsang K.W.T., Lam W.K. and Ip M.S.M., The relationship of insulin resistance, obesity and sleep-disordered breathing , 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology . 2004, 9 (Supp): A143.

Lam J.C.M., Ooi C.G.C., Lam K.S.L., Tam S., Lai A.Y.K., Tsang K.W.T., Lam W.K. and Ip M.S.M., The relationship of insulin resistance, obesity and sleep-disordered breathing, 10th Medical Research Conference, Department of Medicine, The University of Hong Kong, February 2005. Abstract Book: RM 59.

Lam K.S.L., Adipokines, metabolic syndrome and cardiovascular diseases, 10th SCBA (Society of Chinese Bioscientists in America) International Symposium, Beijing, China. 2004.

Lam K.S.L., Dan Q., Xu A., Shen J., Cheng K.Y. and Xu J., Adiponectin stimulates the production o fmaganese superoxide dismutase (SOD2) in human aortic smooth muscle cells, 12th International Congress of Endocrinology, Aug 31 – Sep 4, 2004, Lisbon, Portugal. 2004, A442(1242).

Lam K.S.L. and Tan K.C.B., Adiponectin: protection of the endothelium, Curr Diab Rep. 2005, 5: 254-9.

Lam K.S.L., Associate Editor, Diabetic Medicine. 2004-07-01, Blackwell, 2005.

Lam K.S.L., Editorial Board Member, Diabetes Research & Clinical Practice. Elsevier Scientific Publishers, 2005.

Lam K.S.L., Editorial Board Member, Diabetes, Obesity & Metabolism. Blackwell, 2005.

Lam K.S.L., Fat cells & heart disease, Frontiers in Biomedical Research – Clinical Application, Beijing, China. 2004.

Lam K.S.L., Xu A., Tan K.C.B., Wang Y., Dan Q., Chung S.K. and Chung S.S.M., Inflammation and diabetic atherosclerosis: New players in the field, Int Atherosclerosis Society 2005 Commentaries (Epub). 2005.

Lam K.S.L., Member, Program Organising Committee, 12th International Congress of Endocrinology. 2004.

Lam K.S.L., Reviewer, Diabetes Care. 2004.

Lam K.S.L., Rosie TT Young Endowed Professorship in Endocrinology & Metaolism , The University of Hong Kong. 2005.

Lam K.S.L., Xu A., Tan K.C.B., Wong L.C., Tiu S.C. and Tam S., Serum adiponectin is reduced in acromegaly and normalized after correction of growth hormone excess, Journal of Clinical and Endocrinological Metabablism. 2004, 89(11): 5448-53.

Lam M.C., Tan K.C.B. and Lam K.S.L., Glycoxidized low-density lipoprotein regulates the expression of scavenger receptors in THP-1 macrophages, Atherosclerosis. 2004, 177(2): 313-20.

Mak C.M., Lam K.S.L., Ma O.C., Tso A.W. and Tam S., Novel insertion 496_497insG creating a stop codon D194X in Chinese family with X-Linked adrenoleukodystrophy, Horm Res.. 2005, 63(1): 1-5.

Man Y.B., Cheung B.M.Y., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of Hypertension in the Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong. 2004.

Ong K.L., Wong L.Y.F., Man Y.B., Lam K.S.L. and Cheung B.M.Y., Hypertension is associated with a single nucleotide polymorphism in the uroteinsin II gene, 10th Medical Research Conference, The University of Hong Kong. 19-20 Feb 2005.

Ong K.L., Cheung B.M.Y. and Lam K.S.L., Urotensin II and the Circulatory System, Hong Kong J Nephrol . 2005, 7: 9-14.

Ong K.L., Lam K.S.L. and Cheung B.M.Y., Urotensin II: Its Function in Health and Its Role in Disease, Cardiovascular Drugs Therapy. 2005, 19(1): 65-75.

Rong R., Xu A., Cheung B.M.Y., Cheung G. and Lam K.S.L., Identification of Three Novel Missense Mutations of the Human Melanocortin-4 Receptor Gene in a Chinese Obesity Population, Endocrine Society's 86th Annual Meeting, New Orleans 2004.

Tan K.C.B., Tso A.W.K., Ma O.C., Pang W.C., Tam S. and Lam K.S.L., Determinants of postprandial triglyceride and remnant-like lipoproteins in type 2 diabetes, Diabetes Metabolism Research and Reviews. 2005, 21(2): 209-14.

Tan K.C.B., Xu A., Chow W.S., Ai W.H.G., Tam S. and Lam K.S.L., Hypoadiponectinemia is associated with impaired endothelium-dependent vasodilatation, Journal of Clinical and Endocrinological Metabolism. 2004, 89(2): 765-9.

Thomas G.N., Ho D.S.Y., Lam K.S.L., Janus E.D., Hedley A.J. and Lam T.H., Impact of obesity and body fat distribution on cardiovascular risk factors in Hong Kong Chinese, Obesity Research. 2004, 12(11): 1805-1813.

Thomas G.N., Ho D.S.Y., Janus E.D., Lam K.S.L., Hedley A.J. and Lam T.H., The US National Cholesterol Education Programme Adult Treatment Panel III (NCEP ATP III) prevalence of the metabolic syndrome in a Chinese population, Diabetes Research and Clinical Practice. 2005, 67(3): 251-257.

Tso A.W.K., Wat N.M.S., Xu A., Sham P.C., Rong R., Cheng K.Y., Fong H.Y., Janus E.D. and Lam K.S.L., The adiponectin gene G276T polymorphism is a risk factor for the development of the metabolic syndrome over a period of 5 years in southern Chinese, 12th International Congress of Endocrinology, Aug 31 – Sep 4, 2004, Lisbon, Portugal. 2004, 318 P949.

Wang Y., Lam K.S.L., Xu J., Gang L., Xu L.Y., Cooper G.J. and Xu A., Adiponectin Inhibits Cell Proliferation by Interacting with Several Growth Factors in an Oligomerization-dependent Manner, The Journal of Biological Chemistry. The American Society for Biochemistry and Molecular Biology, 2005, 280: 18341-18347.

Wang Y., Lam K.S.L., Xu J.Y., Lu G., Xu L.Y., Cooper G.J. and Xu A., Adiponectin inhibits cell proliferation by interacting with several growth factors in oligomerization-dependent manner , Journal of Biological Chemistry. 2005, 280(18): 18341-7.

Wang Y., Lu G., Wong W.P.S., Vliegenthart J.F.G., Gerwig G.J., Lam K.S.L., Cooper G.J. and Xu A., Proteomic and Functional Characterizaion of Endogenous Adiponectin Purified from Fetal Bovine Serum, Proteomics. 2004, 4: 3933-3942.

Wang Y., Lu G., Wong W.P., Vliegenthart J.F., Gerwig G.J., Lam K.S.L., Cooper G.J. and Xu A., Proteomic and functional characterization of endogenous adiponectin purified from fetal bovine serium, Proteomics. 2004, 4(12): 3933-42.

Wat N.M.S., Tso A.W.K., Xu A., Sham P.C., Rong R., Cheng K.Y., Fong H.Y., Janus E.D. and Lam K.S.L., The adiponectin gene T45G polymorphism is associated with central obesity and persistent glucose intolerance in high-risk Chinese subjects over 5 years, 12th International Congress of Endocrinology, Aug 31 – Sep 4, 2004, Lisbon, Portugal. 2004.

Xu A., Hoo R.L.C., Hoo R.L.C., Lam C.W., Chen B. and Lam K.S.L., Adenovirus-Mediated Expression of Adiponectin Alleviates Endothelial Dysfunction and Oxidative Stress Associated with db/db Diabetic Mice, The Endocrine Society’s 87th Annual Meeting, June 4-7, 2005, San Diego, USA. 2005.

Xu A., Wang Y., Cooper G. and Lam K.S.L., Angiopietin-like protein 4 is a negative regulator of adipogenesis in 3T3-L1 cells, 12th International Congress of Endocrinology, Aug 31 – Sep 4, 2004, Lisbon, Portugal. 2004, 318 P947.

Xu A., Chan K.W., Wang Y., Zhang J., Hoo R.L.C., Xu J., Chow W.S. and Lam K.S.L., Angiopoietin-like Protein 4 Decreases Blood Glucose and Improves Glucose Tolerance but Induces Hyperlipidemia and Hepatic Steatosis in Mice, Proceedings of the National Academy of Sciences of the United States of America. 2005, 102: 6086-6091.

Xu A., Lam M.C., Chan K.W., Wang Y., Zhang J.C.L., Xu J., Chen B., Chow W.S., Tso A.W. and Lam K.S.L., Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice, Proc Natl Academic Science USA. 2005, 102(17): 6086-91.

Xu A., Lam C.W., Chan K.W., Zhang J., Hoo R.L.C., Xu J., Chen B. and Lam K.S.L., Angiopoietin-like protein 4 is a novel metabolic hormone with therapeutic potentials for hyperglycemia and insulin resistance, 10th Medical Research Conference, The University of Hong Kong. 19-20 Feb 2005. Endocrinology 22.

Xu A., Wong L.C., Wang Y., Xu J., Cooper G.J. and Lam K.S.L., Chronic treatment with growth hormone stimulates adiponectin gene expression in 3T3-L1 adipocytes, FEBS Letters. 2004, 572(1-3): 129-34.

Xu A., Chan K.W., Hoo R.L.C., Wang Y., Zhang J., Chen B., Cynthia T., Cooper G.J.S. and Lam K.S.L., Testosterone Selectively Reduces the High Molecular Weight Form of Adiponectin by Inhibiting Its Secretion from Adipocytes, The Journal of Biological Chemistry. 2005, 280: 18073-18080.

Xu A., Chan K.W., Hoo R.L.C., Wang Y., Tan K.C.B., Zhang J.C.L., Chen B., Lam M.C., Tse C., Cooper G.J. and Lam K.S.L., Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes, J Biol Chem. 2005, 280(18): 18073-80.

Xu J., Dan Q., Chan V.N.Y., Wat N.M.S., Tam S., Tiu S.C., Lee K.F., Siu S.C., Tsang M.W., Fung L.M., Chan K.W. and Lam K.S.L., Genetic and Clinical Characteristics of Maturity-onset Diabetes of the Young in Chinese Patients, European Journal of Human Genetics. 2005, 13: 422-427.

Xu J., Wat N.M.S., Xu A., Cheng K.Y., Sham P.C., Janus E.D. and Lam K.S.L., The G/G Genotype of the -420 C→G Polymorphism in the Resistin Gene Promoter Is Associated with Post-Challenge Glycaemia in Southern Chinese, The Endocrine Society’s 87th Annual Meeting, June 4-7, 2005, San Diego, USA. 2005.

Xu J., Wat N.M.S., Xu A., Cheng K.Y., Sham P.C., Janus E.D. and Lam K.S.L., The G/G genotype of the ->G polymorphism in the resistin gene promoter is associated with post-challenge glycaemia in Southern Chinese, 10th Medical Research Conference, The University of Hong Kong. 19-20 Feb 2005. Endocrinology 26.

Xu R., Li H., Cai K., Sham M.H., Tam P.K.H. and Lam K.S.L., Distribution, pathway and dynamics intake of recombinant adeno-associated virus and gene expression in the gut after oral administration, 10th SCBA International Symposium, Beijing, China, 18-23 July 2004. P2-13-17.

Researcher : Lam SK

Project Title:	Chemoprevention of gastric cancer by intervention with Helicobacter pylori and cyclooxygenase pathway
Investigator(s):	Lam SK, Wong BCY, Xu G.W.
Department:	Medicine
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	12/2001

Abstract:

To assess if the combination of treatment of Helicobacter pylori infection and use of specific cyclooxygenase-2 inhibitors in asymptomatic individuals can reduce the incidence of gastric cancer in a high risk area over a five to ten year period; to assess if the combination of treatment of Helicobacter pylori infection and use of specific cyclooxygenase-2 inhibitors will lead to progression or regression of various precancerous gastric conditions including gastric atrophy, intestinal metaplasia and dysplasia over a three year period; to assess the long term sequelae of Helicobacter pylori eradication and use of specific cyclooxygenase-2 inhibitors histologically, including changes in cell proliferation, apoptosis and oncogene expressions.

Project Title:	Biotech Company in the Faculty of Medicine, The University of Hong Kong
Investigator(s):	Lam SK
Department:	Medicine
Source(s) of Funding:	The University of Hong Kong Foundation Seed Grant
Start Date:	07/2003

Abstract:

To enable the Faculty of Medicine of The University of Hong Kong to establish itself as the regional centre of excellence in the provision of complete solutions to industry from laboratory research services to clinical trials, setting standards and quality benchmarks comparable to the best international practices for other similar centres in the region to follow.

Project Title:	c-Jun NH2-terminal kinase 1 modulates apoptosis of gastric cancer cells through the upregulation of XAF1
Investigator(s):	Lam SK, Wong BCY
Department:	Medical Faculty
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2004
Completion Date:	01/2005

Abstract:

To elucidate the regulation of XAF1 expression in cancer cells by JNK1; to define the role of JNK1 in the upregulations of XAF1 of cancer cells induced by various stimuli; to provide insight into the role of the interaction between JNK1 and IAP family proteins in the occurrence of apoptosis of cancer cells.

Project Title:	Treatment of gastrointestinal cancer by targeting survivin using adeno-associated virus gene delivery system
Investigator(s):	Lam SK, Wong BCY, Lin MC
Department:	Medical Faculty
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2004

Abstract:

To elucidate the molecular mechanisms of survivin in tumor angiogenesis, to will investigater the effect of overexpression of survivin on the migration and capillary tuber-like networks of endothelial cells, expression of angiogenic factors in gastrointestinal cancer cells and angiogenesis in Chorioallantoic membrane angiogenesis (CAM) model and nude mice xenograft; to establish a novel gene therapy for gastrointestinal cancer by targeting survivin gene with adeno-associated virus vector. We will further study the therapeutic effect of rAAV-mediated survivin mutant on gastrointestinal cancer in vivo and evaluate long-term effect and safety of the rAAV virus.

Project Title:	The prevalence of Obstructive Sleep Apnea Syndrome (OSAS) in patients with gastro-oesophageal reflux disease (GERD) and the effects of proton pump inhibitor therapy on OSAS and quality of sleep in Hong Kong Chinese
Investigator(s):	Lam SK, Wong RWM, Ip MSM
Department:	Medical Faculty
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Abstract:

To study the prevalence of Obstructive Sleep Apnea Syndrome (OSAS) in Chinese patients with gastro-oesophageal reflux disease (GERD) and the effects of proton pump inhibitor therapy on OSAS and quality of sleep in patients with GERD.

Project Title:	Treatment of gastrointestinal cancer by targeting survivin using adeno-associated virus gene delivery system
Investigator(s):	Lam SK
Department:	Medical Faculty
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

Refer to hard copy

List of Research Outputs

Chan O.O., Chu K.M., Sun Y., Cheung K.L., Lam S.K., Yuen R.M.F., Hui W.M. and Wong B.C.Y., The association between Interleukin 1 beta polymorphism and hypermethylation at tumor suppressor genes in gastric cancer. Conference paper at the Annual Meeting of the American Gastroenterology Associatoin, Digestive Diseases Week (DDW) Chicago, Illinois, USA. May 14-19, Gastroenterology. 2005, 128(4 Suppl 2): A399.

Gu Q., Wang J., Xia H.H.X., Lin M.C., He H., Zou B., Tu S., Yang Y., Liu X.G., Lam S.K., Wong R.W.M., Chan O.O., Yuen R.M.F., Kung H. and Wong B.C.Y., Activation of the Caspase-8/Bid and Bax Pathways in Aspirin-Induced Apoptosis in Gastric Cancer, Carcinogenesis. 2005, 26(3): 541-546.

Gu Q., Xia H.H.X., Wang W., Wang J., Wong R.W.M., Chan O.O., Yuen M.F., Lam S.K., Cheung K.L., Liu X.G. and Wong B.C.Y., Effect of Cyclo-Oxygenase Inhibitors on Helicobacter pylori Susceptibility to Metronidazole and Clarithromycin, Alimentary Pharmacology and Therapeutics. 2004, 20: 675-681.

Huang J., Zheng G., Hunt R.H., Wong R.W.M., Lam S.K., Karlberg J.P.E. and Wong B.C.Y., Do patients with non-ulcer dyspepsia respond differently to Helicobacter pylorieradication treatments from those with peptic ulcer disease? A systemic review, World Journal of Gastroenterology. 2005, 11 (18): 2726-2732.

Huang J., Zheng G., Chan G.C.F., Karlberg J.P.E., Lam S.K. and Wong B.C.Y., Efficacy of Current Antiemetic Treatments for Preventing Delayed Chemotherapy-Induced Nausea and Vomiting: A Meta-Analysis of Randomized Controlled Trials, Clinical Research and Regulatory Affairs. 2004, 21 (3&4): 191-212.

Jiang X., Tu S., Cui J., Lin M.C., Xia H.H.X., Wong R.W.M., Chan O.O., Yuen M.F., Jiang S.H., Lam S.K., Kung H., Soh J.W., Weinstein I.B. and Wong B.C.Y., Antisense Targeting Protein Kinase C Alpha and Beta1 Inhibits Gastric Carcinogenesis, Cancer Research. 2004, 64: 5787-5794.

Ko J.K.S., Cho C.H. and Lam S.K., Adaptive cytoprotection through modulation of nitric oxide in ethanol-evoked gastritis, World Journal of Gastroenterology. 2004, 10(17): 2503-8.

Lai K.C., Hui W.M., Wong B.C.Y., Hu H.C., Chan O.O. and Lam S.K., Lansorprazole but not Rofecoxib reduced dyspeptic symptoms of patients on NSAIDS, Gastroenterology. 2005, 128(4 Suppl 2): A24.

Lam S.K., Asian Pacific Working Party Meeting on Inflammatory Bowel Disease, Asian Pacific Digestive Week, Beijing (October 4-7, 2004). 2004.

Lam S.K., Epidemiology of GERD in the Asian Pacific Region, 19th World Congress of International Society for Digestive Surgery, Yokohama (December 8-11, 2004). 2004.

Lam S.K., Eradication of H. pylori and Gastric Cancer Experience in Fujian Province, China, Asia Pacific Digestive Week, Beijing (October 4-7, 2004). 2004.

Lam S.K., Pathogenesis of Gastric Cancer – A Unifying Concept, Frontiers in Biomedical Research – Clinical Applications, Beijing (December 6, 2004). 2004.

Lam S.K., Presidential Paper Awards, Asian Pacific Digestive Week, Beijing (October 4-7, 2004). 2004.

Lam S.K., The Genes & Pathologies of the Gastric Cancer Assembly, Asian Pacific Digestive Week, Beijing (October 4-7, 2004). 2004.

Lam S.K., The Status and Perspective of Gastric Diseases in Asia, Asian Pacific Digestive Week, Beijing (October 4-7, 2004). 2004.

Li G., Xia H.H.X., Chen M.H., Chan O.O., Cho C.H., Lam S.K., Berg D., Feng Z., Langenbach R. and Wong B.C.Y., Effects of Cyclooxygenase-1 and -2 Gene Disruption on Helicobacter pylori-Induced Inflammation, Apoptosis and Proliferation, Journal of Gastroenterology and Hepatology. 2004, 19(Suppl.): A299.

Tu S., Cui J., Liston P., Jiang X., Xu R., Lin M.C., Zhu Y.B., Zou B., Ng S.M., Jiang S.H., Xia H.H.X., Wong R.W.M., Chan O.O., Yuen R.M.F., Lam S.K., Kung H. and Wong B.C.Y., Gene Therapy for Colon Cancer by Adeno-Associated Viral Vector-Mediated Transfer of Survivin Cys84Ala Mutant, Gastroenterology. 2005, 128: 361-375.

Wang J., Zou B., Gu Q., Jiang B., Zhuang Z., Xia H.H.X., Lin M.C., Lam S.K., Kung H. and Wong B.C.Y., Down-regulation of XAF1 expression by its interacting protein FHL2 via p53-mediated transcription regulation, Gastroenterology. 2005, 128(4 Suppl 2): A105.

Wang J., Gu Q., He H., Jiang B., Zhuang Z., Xia H.H.X., Lin M.C., Lam S.K., Kung H. and Wong B.C.Y., Down-regulation of XIAP associated factor 1 (XAF1) through Hsf-1 binding in the promoter region, Gastroenterology. 2005, 128(4 Suppl 2): A105.

Wang W.H., Huang J., Zheng G., Wong R.W.M., Lam S.K., Karlberg J.P.E., Xia H.H.X., Fass R. and Wong B.C.Y., Is Proton Pump Inhibitor Testing an Effective Approach to Diagnose Gastroesophageal Reflux Disease in Patients With Noncardiac Chest Pain?, Archives of Internal Medicine. 2005, 165: 1222-1228.

Wong B.C.Y., Chan O.O., Wong K.W., Ching C.K., Wong R.W.M., Tam S., Lai K.C., Chan C.K., Yuen R.M.F. and Lam S.K., A pilot study of participation in faecal occult blood testing and screening colonoscopy after health education in Hong Kong, European Journal of Cancer Preview. 2005, 14(2): 181-184.

Wong R.W.M., Huang J., Xia H.H.X., Fung F.M.Y., Tong S.M., Cheung K.L., Ho Y.K., Lai K.C., Chan C.K., Chan O.O., Hui C.K., Lam S.K. and Wong B.C.Y., Low-dose rabeprazole, amoxicillin and metronidazole triple therapy for the treatment of Helicobacter pylori infection in Chinese patients , Journal of Gastroenterology and Hepatology. 2005, 20(6): 935-940.

Wong R.W.M., Lai K.C., Hui W.M., Hu H.C., Huang J., Wong Y.H., Xia H.H.X., Chan O.O., Lam S.K. and Wong B.C.Y., Pathophysiology of Gastroesophageal Reflux Diseases in ChineseRole of Transient Lower Esophageal Sphincter Relaxation and Esophageal Motor Dysfunction, American Journal of Gastroenterology. 2004, 99: 2088-2093.

Wong R.W.M., Xiao S.D., HU P.J., Wang W., Gu Q., Huang J., Xia H.H.X., WU S.M., LI C.J., CHEN M.H., CUI Y., Lai K.C., Hu H.C., Chan C.K., Lam S.K. and Wong B.C.Y., Standard treatment for Helicobacter pylori infection is suboptimal in non-ulcer dyspepsia compared to duodenal ulcer in Chinese, Alimentary Pharmacology and Therapeutics. 2005, 21: 73-81.

Wong W.M., Lai K.C., Lam K.F., Hui W.M., Huang J.Q., Xia H.H.X., Hu H.C., Lam C.L.K., Chan C.K., Lam S.K. and Wong B.C.Y., Onset and disappearance of Reflux Symptoms in a Chinese population: a one-year follow-up study, Alimentary Pharmacology and Therapeutics. 2004, 20: 803-812.

Xia B., Xia H.H.X., Lam S.K., Chan O.O., Lai K.C., Hu H.C. and Wong B.C.Y., Trends in prevalence of peptic ulcer disease and Helicobacter pylori infection and frequency of NSAID intake in general practitioner-referred dyspeptic patients over 6 years in Hong Kong, Gastroenterology. 2005, 128(4 Suppl 2): A230.

Xia H.H.X., Yang Y., Lam S.K., Wong R.W.M., Leung S.Y., Yuen S.T., Elia G., Wright N.A. and Wong B.C.Y., Aberrant Epithelial Expression of Trefoil Family Factor 2 and Mucin 6 in Helicobacter pylori infected gastric antrum, incisura, and body and its association with antralisation, Journal of clinical pathology. 2004, 57: 861-866.

Xia H.H.X., Wong B.C.Y., Zhang G.S., Yang Y., Wyatt J.M., Adams S., Cheung K., Lam S.K. and Talley N.J., Antralization of Gastric Incisura is Topographically Associated with Increased Gastric Epithelial Apoptosis and Proliferation, but not with CagA Seropositivity, Journal of Gastroenterology and Hepatology. 2004, 19: 1257-1263.

Xia H.H.X., Li G., Chen M.H., Chan O.O., Cho C.H., Lam S.K., Berg D., Feng Z., Langenbach R. and Wong B.C.Y., Cyclooxygenase-1 and -2 Gene Disruption Potentiate TH1 Polarization in Response to Helicobacter pylori, Journal of Gastroenterology and Hepatology. 2004, 19(Suppl.): A366.

Xia H.H.X., Zhang S., Lam S.K., Lin M.C., Kung H. and Wong B.C.Y., Expression of Macrophage Migration Inhibitory Factor in Esophageal Squamous Cell Carcinoma and Effects of Bile Acids and NSAIDs, Carcinogenesis. 2005, 26(1): 11-15.

Xia H.H.X., Lam S.K., Chan O.O., Lin M.C., Kung H., Ogura K., Berg D.E. and Wong B.C.Y., Macrophage Migration Inhibitory Factor Stimulated by Helicobacter pylori Increases Proliferation of Gastric Epithelial Cells, World Journal of Gastroenterology. 2005, 11(13): 1946-1950.

Xia H.H.X., Lam S.K., Huang X.R., Wong R.W.M., Leung S.Y., Yuen S.T., Lan H.Y. and Wong B.C.Y., Helicobacter pylori Infection is Associated with Increased Expression of Macrophage Migratory Inhibitory Factor - by Epithelial Cells, T Cells, and Macrophages - in Gastric Mucosa, The Journal of Infectious Diseases. 2004, 190: 293-302.

Zhu S., Xia H.H.X., Lam S.K., Yu L., Yang Y., Sun Y., Wang J., Chan O.O. and Wong B.C.Y., Alterations of gastric homeoprotein expression in H. Pylori infection and/or intestinal metaplasia, Gastroenterology. 2005, 128(4 Suppl 2): A598.

Zhuang Z., Tsao G.S.W., Xia H.H.X., He H., Chan O.O., Lam S.K. and Wong B.C.Y., COX-2 inhibition induces apoptosis in human esophageal epithelial cells: implication for chemoprevention, Gastroenterology. 2005, 128(4 Suppl 2): A299.

Researcher : Lam SY

List of Research Outputs

Lam B., Tam C.M., Lam S.Y., Wong M.P., Ooi C.G.C., Fung S.L., Ip M.S.M. and Lam W.K., Detection of early lung cancer in high risk population : a prospective study, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A122.

Researcher : Lam TP

List of Research Outputs

Cheung K.L. and Lam T.P., Approach to a lump in the breast - a regional perspective., Asian Journal of Surgery. 2005, 28(1): 65-70.

Chung J.T.N., Wun Y.T. and Lam T.P., Vocational training in Family Medicine: the trainers' perspectives., Wonca World Conference in Orlando, USA. 2004.

Lam T.P., March 1995 – April 2005 Honorary Senior Lecturer, Department of Community Medicine & General Practice, Monash University, Australia. , 2005.

Lam T.P., May 2005 – To Date Honorary Associate Professor, Department of Community Medicine & General Practice, Monash University, Australia , 2005.

Lam T.P., Kong T.K., Chan F.H.W. and Wong C.P., A postgraduate diploma course in community geriatrics for primary care doctors: experience of first three years., Hong Kong Practitioner. 2004, 26: 441-446.

Lam T.P., Co-Editor of Asia Pacific Family Medicine, the Official Journal of Wonca Asia Pacific. 2005.

Lam T.P., Food for thought., Australian Universities Alumni Convention. Hong Kong, 2004.

Lam T.P., General Practice / Family Practice as a Global Standard: views from Hong Kong, Invited Symposium, 2005 Wonca Asia Pacific Regional Conference. Kyoto, Japan, 2005.

Lam T.P., Health promotion in the elderly., A seminar for the Diploma in Family Medicine run by the Hong Kong College of Family Physicians. Hong Kong, 2004.

Lam T.P. and Cheng Y.H., Low literacy Chinese patients: How are they affected with health matters?, 10th Medical Research Conference, The University of Hong Kong. Hong Kong, 2005.

Lam T.P., May 2005 – To Date Honorary Associate Professor, Department of Community Medicine & General Practice, Monash University, Australia. , 2005.

Lam T.P., Preventive geriatrics., Shatin Hospital. Hong Kong, 2004.

Lam T.P., Qualitative Research: methods and difficulties., Research Group, Department of Health. Hong Kong, 2004.

Lam T.P., Khoo U.S., Chan Y.S., Cheng Y.H. and Lam K.F., The first batch of graduates of a new medical curriculum in Asia: how their teachers see them, Medical Education. 2004, 38(9): 980-986.

Sturmberg J., Freeman G.K., Gill N., Lam T.P. and Trader J.M., Access to care and its impact on personal provider continuity., Wonca World Conference in Orlando, USA. 2004.

Researcher : Lam WK

List of Research Outputs

Bovornkitti S., Lam W.K. and Chan M.M.W., Smoking and lung health. In Ed. Ip MSM, Chan MMW, Lam WK, Zhong NS, Respiratory Medicine : An Asian Perspective. Hong Kong University Press, Hong Kong, 2005, Chapter 20: 347-363.

Chan M.M.W., Tan-Un K.C., Ip M.S.M., Tsang K.W.T., Ho S.P., Ho J.C.M., Chan H. and Lam W.K., Lung Cancer Susceptibility and Polymorphism of Glutathione-S-transferase Genes in Hong Kong, Lung Cancer. 2004, 45(2): 155-160.

Chan M.M.W., Lam W.K., Mak J.C.W., Ho S.P., Chan H.W., Tsang K.W.T., Ip M.S.M., Ho J.C.M., Wong M.P. and Tan-Un K., Polymorphisms of CYP and GST genes, passive smoke and lung cancer risk in Hong Kong Chinese, European Respiratory Journal. 2004, 24: Suppl 48: 457s.

Ho J.C.M., Lam W.K., Wong M.P., Wong M.K., Ooi C.G.C., Ip M.S.M., Chan M.M.W. and Tsang K.W.T., Lymphoepithelioma-like carcinoma of the lung : experience with ten cases, International Journal of Tuberculosis and Lung Disease. 2004, 8(7): 890-895.

Ho J.C.M., Mak J.C.W., Ho S.P., Ip M.S.M., Tsang K.W.T., Lam W.K. and Chan M.M.W., Manganese superoxide dismutase and catalase genetic polymorphisms activity levels and lung cancer risk in Chinese in Hong Kong, 10th Medical Research Conference, Department of Medicine, The University of Hong Kong, February 2005. Abstract Book: RM 66.

Ho J.C.M., Ho S.P., Chan M.M.W., Mak J.C.W., Ip M.S.M., Ko K.W., Yan C.P.K., Wong M.P., Tsang K.W.T. and Lam W.K., Non-small cell lung cancer in Chinese is associated with disturbance in systemic antioxidant profiles, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December, 2004. Respirology. 2004, 9 (Supp): A114.

Ho J.C.M., Wu A.Y.Y., Lam B., Ooi C.G.C., Khong P.L., Ho P.L., Chan M.M.W., Zhong N.S., Ko K.W., Lam W.K. and Tsang K.W.T., Pentaglobin in steroid-resistant severe acute respiratory syndrome, International Journal of Tuberculosis and Lung Disease. 2004, 8(10): 1173-1179.

Ho S.P., Chan M.M.W., Wong M.P., Tsang K.W.T., Ip M.S.M., Lam W.K. and Mak J.C.W., Transforming growth factor (TGF)-beta 1 gene common polymorphisms and plasma TGF-beta 1 levels in patients with lung cancer, 10th Medical Research Conference, Department of Medicine, The University of Hong Kong, February 2005. Abstract Book: RM 60.

Ho S.P., Chan M.M.W., Tsang K.W.T., Ip M.S.M., Lam W.K. and Mak J.C.W., Transforming growth factor (TGF)-beta 1 gene common polymorphisms and plasma TGF-beta 1 levels in patients with lung cancer, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A120.

Ip M.S.M., Chan M.M.W., Lam W.K. and Zhong N.S., Respiratory Medicine - An Asian Perspective. Hong Kong University Press, 2005.

Ip S.K., Tsang K.W.T. and Lam W.K., Idiopathic Pulmonary Fibrosis in Hong Kong SAR , Abstract Book of the 10th Medical Research Conference, University Department of Medicine, The Univeristy of Hong Kong, 19-20 February. 2005, page 63.

Ip S.K., Tsang K.W.T. and Lam W.K., Idiopathic pulmonary fibrosis in Hong Kong SAR, Respirology. 2004, 9 (suppl): A111 (274).

Kwok P.W., Leung Y.H., Sun J.Z., Yan C.P.K., Ooi C.G.C., Ho P.L., Ho J.C.M., Tipoe G.L., Lam W.K. and Tsang K.W.T., The Effects of Gelomyrtol Forte on Human Ciliary Beat Frequency in vitro, Abstract Book of the 10th Medical Research Conference, University Department of Medicine, The University of Hong Kong, 19-20 February. 2005, page 65.

Kwok R., Leung Y.H., Sun J.Z., Yan C.P.K., Ooi C.G.C., Ho P.L., Ho J.C.M., Tipoe G.L., Lam W.K. and Tsang K.W.T., The effects of gelomyrtol forte on human ciliary beat frequency in vitro, Respirology. 2004, 9 (Suppl): A162 (290).

Lam B., Sam K., Mok W.Y.W., Lam J.C., Yam L.Y.C., Lam W.K. and Ip M.S.M., A randomized study of three non-surgical treatment options in mild to moderate obstructive sleep apnea, American Thoracic Society International Conference, San Diego, USA. May 2005. Proceedings of the American Thoracic Society. 2005, p.A303.

Lam B., Tam C.M., Lam S.Y., Wong M.P., Ooi C.G.C., Fung S.L., Ip M.S.M. and Lam W.K., Detection of early lung cancer in high risk population : a prospective study, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A122.

Lam C.L., Wong M.P., Girard L., Chung L.P., Chau W.S., Chiu S.W., Lam W.K. and Minna J.D., Gene expression profiling in lung adenocarcinomas reveals molecular signatures of potential biological significance , Journal of The Japanese Respiratory Society. 2005, 43 (Suppl): 115 (EO6-3).

Lam D.C.L., Wong M.P., Girard L., Shigematsu H., Chung L.P., Gazdar A.F., Chiu S.W., Suen W.S., Lam W.K. and Minna J.D., Expression profiling in lung adenocarcinoma with or without Epidermal Growth Factor Receptor (EGFR) gene mutation at exons 18-21 reveals expression signatures related to the EGFR pathway, 96th Annual Meeting of the American Association for Cancer Research, Anaheim, CA, USA, April. 2005, P.O.CB 39: 888/B#9.

Lam D.C.L., Wong M.P., Girard L., Chung L.P., Chau W.S., Chiu S.W., Lam W.K. and Minna J.D., Gene expression profiling in lung adenocarcinomas reveals molecular signatures of potential biological significance, Respirology. 2004, 9 (Suppl): A121 (236).

Lam J.C.M., Ooi C.G.C., Lam K.S.L., Tam S., Lai A.Y.K., Tsang K.W.T., Lam W.K. and Ip M.S.M., The relationship of insulin resistance, obesity and sleep-disordered breathing , 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology . 2004, 9 (Supp): A143.

Lam J.C.M., Ooi C.G.C., Lam K.S.L., Tam S., Lai A.Y.K., Tsang K.W.T., Lam W.K. and Ip M.S.M., The relationship of insulin resistance, obesity and sleep-disordered breathing, 10th Medical Research Conference, Department of Medicine, The University of Hong Kong, February 2005. Abstract Book: RM 59.

Lam W.K., APSR Congress in Hong Kong, 2004, 9th Asian Pacific Society of Respirology Congress Brochure, December. 2004.

Lam W.K., Associate Editor, International Journal of Tuberculosis and Lung Disease. 2005.

Lam W.K., Co-chairperson in Parallel Session 2A : Radiology grand round, 9th Congress of the Asian Pacific Society of Respirology, December. 2004.

Lam W.K., Co-chairperson in Plenary Lecture 3 : Lung cancer, 9th Congress of the Asian Pacific Society of Respirology, December . 2004.

Lam W.K., Co-chairperson in Satellite Symposium 1 : A world without asthma - a goal for today , 9th Congress of the Asian Pacific Society of Respirology, December. 2004.

Lam W.K., Co-chairperson in Satellite Symposium 3 : Latest development for the treatment of lung cancer, 9th Congress of the Asian Pacific Society of Respirology, December. 2004.

Lam W.K., Tsang K.W.T., Ooi C.G.C., Ip M.S.M. and Chan M.M.W., Infections: Severe Acute Respiratory Syndrome., In: Ip M, Chan-Yeung M, Lam WK, Zhong NS, Respiratory Medicine, An Asian Perspective. Hong Kong, Hong Kong University Press, 2004, 307-323.

Lam W.K., Lung Cancer Series, Respirology. 2005.

Lam W.K. and Yang P.C., Lung cancer : diagnosis and staging. In Ed. Ip MSM, Chan MMW, Lam WK, Zhong NS, Respiratory Medicine : An Asian Perspective. Hong Kong, Hong Kong University Press, 2005, Chapter 24: 423-435.

Lam W.K. and Liao M.L., Lung cancer : epidemiology and risk factors. In Ed. Ip MSM, Chan MMW, Lam WK, Zhong NS, Respiratory Medicine : An Asian Perspective. Hong Kong University Press, Hong Kong, 2005, Chapter 23: 403-422.

Lam W.K., White N.W. and Chan M.M.W., Lung cancer epidemiology and risk factors in Asia and Africa, International Journal of Tuberculosis and Lung Disease . 2004, 8: 1045-1057.

Lam W.K., Lung cancer in Asian women - the environment and the gene, 9th Congress of the Asian Pacific Society of Respirology . 2004, Abstract Book: p.64.

Lam W.K., Member of Editoiral Board, MIMS Respiratory Guide. 2005.

Lam W.K., Member of Editorial Board, Chinese Journal of Internal Medicine. 2004.

Lam W.K., Member of Editorial Board, Chinese Journal of Internal Medicine. 2005.

Lam W.K., Member of Editorial Board, Chinese Journal of Lung Cancer. 2004.

Lam W.K., Member of Editorial Board, Chinese Journal of Lung Cancer. 2005.

Lam W.K., Member of Editorial Board, Disease Management. 2004.

Lam W.K., Member of Editorial Board, Disease Management. 2005.

Lam W.K., Member of Editorial Board, MIMS Respiratory Guide. 2004.

Lam W.K., Member of Editorial Board, Respirology. 2004.

Lam W.K., Member of Editorial Board, Respirology. 2005.

Lam W.K., Member of Honorary Advisory Board, DRUG (Indexed Medical Specialties). 2004.

Lam W.K., Member of Honorary Advisory Board, DRUG (Indexed Medical Specialties). 2005.

Lam W.K., Member of International Advisory Board, Internal Medicine. 2004.

Lam W.K., Member of International Advisory Board, Internal Medicine. 2005.

Lam W.K., Message from the President, Asian Pacific Society of Respirology Newsletter. 2004, 13(1): 1-2.

Lam W.K., Professor Yoshinosuki Fukuchi on his retirement, Professor Yoshinosuki Fukuchi Retirement Memoir. Juntendo University Press, Tokyo, Japan, 2005, 148-149.

Lam W.K., Report on the 9th Congress of the APSR, Asian Pacific Society of Respirology Newsletter . 2004, 13(2): 2-3.

Lam W.K., Ho J.C.M., Lam B. and Tsang K.W.T., SARS and impacts on travel, Textbook of Travel Medicine . Bangkok Press, Bangkok, 2004, Chapter 38: 405-414.

Lam W.K., Tsang K.W.T., Ooi C.G.C., Ip M.S.M. and Chan M.M.W., Severe Acute Respiratory Syndrome. In: Ed. Ip MSM, Chan MMW, Lam WK, Zhong NS, Respiratory Medicine - An Asian Perspective. Hong Kong University Press, 2005, Chapter 18: pp. 307-323.

Lam W.K., The Asian Pacific Society of Respirology, Respiratory Care Matters. 2004, 9: 10-11.

Mak J.C.W., Ho S.P., Leung Y.H., Ho P.L., Ooi C.G.C., Yan C.P.K., Ko K.W., Ip M.S.M., Lam W.K. and Tsang K.W.T., Elevated levels of transforming growth factor- beta 1 in serum of patients with stable bronchiectasis, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A134.

Mak J.C.W., Leung C.M., Ho S.P., Law K.W., Tsang K.W.T., Lam W.K., Ip M.S.M. and Chan M.M.W., Genetic susceptibility of transforming growth factor beta-1 common polymorphisms to Chinese patients with asthma, American Thoracic Society International Conference, San Diego, USA. May 2005. Proceedings of the American Thoracic Society. 2005, p.A78.

Mak J.C.W., Ho J.C.M., Ho S.P., Yu W.C., Yew W.W., Tsang K.W.T., Lam W.K., Ip M.S.M. and Chan M.M.W., Increased oxidative stress and altered antioxidant status in Chinese patients with COPD, European Respiratory Journal. 2004, 24: Suppl 48: 62s.

Mak J.C.W., Leung H.C., Ho S.P., Lam W.K., Tsang K.W.T., Ip M.S.M. and Chan M.M.W., Systemic antioxidant status in Chinese patients with asthma, European Respiratory Journal. 2004, 24: Suppl 48: 509s.

Mak J.C.W., Leung C.M., Ho S.P., Lam W.K., Tsang K.W.T., Ip M.S.M. and Chan M.M.W., Systemic oxidative and antioxidative status in Chinese patients with asthma, Journal of Allergy and Clinical Immunology. 2004, 114(2): 260-264.

Tam I.Y.S., Wong M.P., Chau W.S., Wang E., Lam W.K., Chiu S.W. and Chung L.P., EGFR mutations are prevalent and independent from K-RAS mutations in lung adenocarcinomas from non-smokers, 9th Research Postgraduate Symposium, The University of Hong Kong, Hong Kong, 4 December 2004.

Tam I.Y.S., Wong M.P., Suen W.S., Wang E., Lam W.K., Chiu S.W., Gazdar A., Minna J.D. and Chung L.P., EGFR mutations are prevalent and independent from k-RAS mutations in lung adenocarcinomas from non-smokers, 96th Annual Meeting of the American Association for Cancer Research, Anaheim, CA, USA, April. 2005, M.S.CL00.01: 1666.

Tsang K.W.T., Tipoe G.L., Mak J.C.W., Sun J.Z., Wong M.P., Leung R.C.M., Tan K.C.B., MedStat C.K.M., Ho J.C.M., Ho P.L., Rutman A. and Lam W.K., Ciliary central microtubular orientation is of no clinical significance in bronchiectasis, Respiratory Medicine. 2005, 99: 290-297.

Tsang K.W.T., Tipoe G.L., Sun J.Z., Tan K.C.B., Leung Y.H., Yan C.P.K., Ko K.W., Ooi C.G.C., Ho J.C.M. and Lam W.K., Clinical value of ciliary assessment in bronchiectasis, Lung. 2005, 183(2): 73-86.

Tsang K.W.T., Tan K.C.B., Ho P.L., Ooi C.G.C., Khong P.L., Leung Y.H., Mak J.C.W., Tipoe G.L., Ko K.W. and Lam W.K., Exhaled nitric oxide in bronchiectasis: the effects of inhaled corticosteroid therapy, International Journal of Tuberculosis and Lung Disease. 2004, 8(11): 1301-1307.

Tsang K.W.T., Tan K.C.B., Ho P.L., Ooi C.G.C., Ho J.C., Mak J.C.W., Tipoe G.L., Ko C., Yan C. and Lam W.K., Inhaled fluticasone in bronchiectasis: a 12 month study, Thorax. 2005, 60: 239-243.

Wong M.K., Lam J.C., Ip S.K., Ip M.S.M., Lam W.K. and Tsang K.W.T., A comparative study on the efficacy of sequential intravenous and oral levofloxacin versus ceftazidime in treatment of infective exacerbation of bronchiectasis, 10th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2005, Abstract Book: RM 64.

Wong M.K., Lam J., Ip S., Lam C.L., Ip M.S.M., Lam W.K. and Tsang K.W.T., Quality of life effect of levofloxacin compared to ceftazidime treatment in infective exacerbation of bronchiectasis, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A135.

Wong M.P., Lam D.C.L., Yap D.Y.L., Girard L., Tam I.Y.S., Chung L.P., Chiu S.W., Lam W.K., Danchin A. and Minna J.D., Identification of discriminating gene expression of EBV-associated primary lymphoepitheioma-like carcinoma of lung by oligonucleotide microarray analysis , 96th Annual Meeting of the American Association for Cancer Research, Anaheim, CA, USA, April. 2005, P.O.CB19: 75/B#3.

Yap Y.L., Lam C.L., Girard L., Zhang X., Hernandez D., Gras R., Wang E., Chiu S. .W., Chung L.P., Lam W.K., Smith D.K., Minna J. .D., Danchin A. and Wong M.P., Conserved transcription factor binding sites of cancer markers derived from primary lung adenocarcinoma microarrays, Nucleic Acids Research. Oxford University Press 2005, 2004, 33 No. 8: 2764.

Zhu H., Wong M.P., Lam C.L., Cai W.W., Chau W.S., Wang E., Lam W.K., Chiu S.W. and Chung L.P., High-resolution analysis of DNA copy number alterations and expression profiling by microarray technology in primary lung cancer cell lines, 9th Research Postgraduate Symposium, The University of Hong Kong, Hong Kong, 4 December 2004.

Researcher : Lam YM

List of Research Outputs

Siu C.W., Tse H.F., Lee K.L.F., Lam Y.M., Yung L.Y. and Lau C.P., A rapid ultrasonic cardiac output monitor method for optimization of ventriculo-ventricular interval (VVI) in cardiac resynchronization therapy., Heart Rhythm. 2005, 2: S84.

Researcher : Lan HY

List of Research Outputs

Ren Y., Lin C.L., Li Z., Chen X.Y., Huang X., Lui V.C.H., Nicholls J.M., Lan H.Y. and Tam P.K.H., Up-regulation of macrophage migration inhibitory factor in infants with acute neonatal necrotizing enterocolitis, Histopathology. 2005, 46(6): 659-667.

Xia H.H.X., Lam S.K., Huang X.R., Wong R.W.M., Leung S.Y., Yuen S.T., Lan H.Y. and Wong B.C.Y., Helicobacter pylori Infection is Associated with Increased Expression of Macrophage Migratory Inhibitory Factor - by Epithelial Cells, T Cells, and Macrophages - in Gastric Mucosa, The Journal of Infectious Diseases. 2004, 190: 293-302.

Researcher : Lau CP

Project Title:	Evaluation of the antianginal efficacy and safety of oral chronic administration of ivabradine (5mg b.i.d. then 7.5mg b.i.d or 10mg b.i.d) compared to atenolol (50mg o.d then 100mg o.d), in patients with stable effort angina pectorals
Investigator(s):	Lau CP, Lee KLF, Lee P.Y.
Department:	Medicine
Source(s) of Funding:	Other Funding Scheme
Start Date:	05/2000

Abstract:

To demonstrate the non-inferiority of invabradine 7.5mg b.i.d then 10mg b.i.d in improving exercise capacity in comparison to atenolol given by oral route for 4 and a half months to out-patients with chronic stable angina; to determine pharmacokinetic parameters.

Project Title:	Roles of macrophage migration inhibitory factor (MIF) in acute myocardial infarction
Investigator(s):	Lau CP, Yu CM, Lan HY
Department:	Medicine
Source(s) of Funding:	Low Budget High Impact Programme
Start Date:	11/2000

Abstract:

To investigate the pathogenic role and mechanism of macrophage migration inhibitory factor (MIF) after myocardial infarction (AMI).

List of Research Outputs

Chan S.S.C., Lam T.H. and Lau C.P., Smoking status and predictors of readiness to quit in cardiac patients, American Public Health Association 132nd Annual Meeting and Exposition, Washington, DC, November 6-10, 2004. Washington, DC.

Chan S.S.C., Lam T.H. and Lau C.P., The effectiveness of a nurse-delivered smoking cessation intervention for cardiac patients: A randomised controlled trial, Society for Research on Nicotine and Tobacco 11th Annual Meeting held jointly with the 7th Annual SRNT European Conference. Prague, Czech Republic, 2005.

Chen W.H., Lee P.Y., Ng W., Kwok J.Y.Y., Cheng X., Tse H.F. and Lau C.P., Prevalence profile, and predictors of aspirin resistance measured by the Ultegra Rapid Platelet Function Assay-ASA in patients with coronary artery disease, J Am Coll Cardiol. 2005, 45: 382A.

Cheung B.M.Y., Man Y.B., Tse H.F., Kumana C.R. and Lau C.P., Advantages of Blood Pressure Optimisation Study, J Hong Kong Coll Cardiol . 2004, 12: 33.

Cheung B.M.Y., Leung Y.H., Man Y.B., Wong L.Y.F. and Lau C.P., Association of Blood Pressure and Obesity with a Single Nucleotide Polymorphism at 17p12, American Journal of Hypertension. 2005, 18(5) Suppl: A79.

Cheung B.M.Y., Leung Y.H., Man Y.B. and Lau C.P., Association of Essential Hypertension with the WNK4 Gene, the Molecular Switch Controlling Renal Sodium and Potassium Excretion, Cardiovasc Drugs Thera. 2004, 18 (Suppl) 1: 8.

Cheung B.M.Y., Lam T.H., Lam K.S.L., Tam S., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Man Y.B., Cheng C.H., Kumana C.R. and Lau C.P., Follow Up of the Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., High Blood Pressure is Related to Obesity in Hong Kong, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Lipid Profile of the Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Cheung G.T.Y., Lauder I.J., Lau C.P. and Kumana C.R., Meta-analysis of Large Outcome Trials of Angiotensin Receptor Blockers in Hypertension, American Journal of Hypertension. 2005, 18(5) Suppl: A53.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Obesity in the Hong Kong Cardiovascular Risk Factor Prevalence Survey-2 (CRISPS2) Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of Diabetes Mellitus (DM) in the Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Wat N.M.S., Lo L.F., Chau F.Y., Lam T.H., Leung G.M., Tam S., Cheng C.H., Kumana C.R., Lau C.P. and Lam K.S.L., Prevalence of Hypertension in Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort, J Hong Kong Coll Cardiol. 2004, 12: 33.

Cheung B.M.Y., Law C.Y., Ho G.Y.Y., McGhee S.M., Man Y.B., Ng P.P.Y., Kumana C.R. and Lau C.P., Randomised Controlled Trial of Low Salt Diet Versus Drug Treatment in the Management of Mild hypertension, 8th Scientific Meeting of the Hong Kong Pharmacology Socieity in Association with the Shanghai Pharmacology Society, Hong Kong 2004.

Cheung B.M.Y., Lo L.F., Fong D.Y.T., Chan M.Y., Wong W.H.S., Lau C.P., Lam K.S.L., Wong V.C.N. and Karlberg J.P.E., Randomised Controlled Trial of Qigong in Hypertension, Cardiovasc Drugs Thera. 2004, 28 (suppl) 1: 28.

Cheung B.M.Y., Lo L.F., Fong D.Y.T., Chan M.Y., Wong W.H.S., Lau C.P., Lam K.S.L., Wong V.C.W. and Karlberg J.P.E., Randomised controlled trial of qigong in hypertension, J Hong Kong Coll Cardiol. 2004, 12: 34.

Cheung B.M.Y., Lo L.F., Fong D.Y.T., Chan M.Y., Wong S.H.T., Wong V.C.W., Lam K.S.L., Lau C.P. and Karlberg J.P.E., Randomised controlled trial of qigong in the treatment of mild essential hypertension, J Hum Hypertens. 2005, 19(9): 697-704.

Cheung B.M.Y., Law C.Y., Ho G.Y.Y., McGhee S.M., Man Y.B., Ng P.P.Y., Kumana C.R. and Lau C.P., Randomsed Controlled Trial of Low Salt Diet Versus Drug Treatment in Hypertension, Cardiovasc Drugs Thera. 2004, 18 (Suppl) 1: 15.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Relationship Between Hypertension and Obesity in Hong Kong, 3rd Asian-Pacific Congress on Hypertension, Singapore 2004.

Cheung B.M.Y., Lam T.H., Lam K.S.L., Tam S., Wat N.M.S., Man Y.B., Cheng C.H., Kumana C.R. and Lau C.P., The Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort - Results at 7 Years, J Hypertens. 2004, 22 (Suppl 2): S268-269.

Cheung B.M.Y., Law C.Y., McGhee S.M., Ng P.P.Y., Kumana C.R. and Lau C.P., The Relationship Between Sodium and Blood Pressure in Hong Kong Chinese, Clin Res Regul Aff. 2004, 21(2): 145-154.

Deng X., Sun H., Lau C.P. and Li G.R., Protein Tyrosine Kinase Modulates Voltage-gated Delayed Rectifier Potassium Channels In Rat Mesenchymal Stem Cells From Bone Marrow, Journal of Hong Kong College Cardiology. 2004, 12: 101(P12).

Dong M., Lau C.P., Gao Z. and Li G.R., Effects Of Protein Tyrosine Kinase Inhibitors On Cloned Human Cardiac IKs Expressed In Hek 293 Cell Line., Journal of Hong Kong College Cardiology. 2004, 12(3/4): 93.

Gao Z., Sun H., Chiu S.W., Lau C.P. and Li G.R., Effects Of Diltiazem And Nifedipine On Transient Outward And Ultra-rapid Delayed Rectifier Potassium Currents In Human Atrial Myocytes, Br J Pharmacol. 2005, 144: 495-604.

Kwong Y.L., Tse H.F. and Lau C.P., Comparative evaluation of platelet and coagulation activation during transvenous cryoablation and radiofrequency ablation for pulmonary veinablation in patients with atrial fibrillation, J Am Coll Cardiol 2005. 45: 120A.

Lau C.P., 11th International Symposium on Progress in Clinical Pacing ?Lecture on "Automatic device evaluation of hemodynamic deterioration" Debating on All VVI “Class III patients should be upgraded to biventricular pacing " ?Chair Symposium " Contracticity Sensors to guide pacemakers and ICD Function" , AIAC. Rome, Italy, 2004.

Lau C.P., 15th ASEAN Congress of Cardiology ?How-to Session VIII: Cardiac Resynchronization Therapy for CHF :Patients selection ?Meet the expert X: Selecting an Appropriate permanent Pacemaker for your patients- patients with atrial fibrillation , Heart Association of Thailand under the Royal patronage. Pattaya,Thailand, 2004.

Lau C.P., 20th Annual Scientific Meeting of the Japanese Society of Cardiac Pacing & Electrophysiology) ? Luncheon seminar: Pacing from non-traditional sites ? Special lecture: Optimal Programming of CRT to prevent non-responders (synchronicity, tissue Doppler, CARTO data) , Japan Society of Pacing & Electrophysiology. Takarazuka Japan, 2005.

Lau C.P., 3rd International Congress on Cardiovascular Disease (ICCD) ?Congestive Heart failure: Selecting the appropriate permanent pacemaker for Cardiac resynchronization , Taiwan Society of Cardiology. Taiwan, 2004.

Lau C.P., 7th Annual Conference on Advances in Cardiology & Cardiovascular Therapeutics Topic: Pacing in Heart Failure , ICEM Sdn Bhd . Kuala Lumpur, Malaysia, 2004.

Lau C.P., Advances in Cardiac Rhythm Management First Annual Meeting ?Advances in Electrophysiology and Haemodynamics of Arrhythmias: Haemodynamic and echocardiographic insights ?Session 3: Prevention of Sudden Cardiac Death – Primary prevention: Genetic Screening , Indian Working Group on Pacing and Electrophysiology. Delhi, India, 2005.

Lau C.P., Association of Essential Hypertension with the WNK4 Gene, the Molecular Switch Controlling Renal Sodium and Potassium Excretion, In: Willem J. Remme, Cardiovascular Drugs and Therapy, First Global Conference on Cardiovasular Clinical Trials and Pharmacotherapy . Kluwer Academic Publishers, 2004, 18(S1).

Lau C.P., AstraZeneca Asia Pacific Cardiovascular Summit Meeting Cardiovascular Disease – Improving Treatments, Reducing Risk , AstraZeneca. Hong Kong, 2005.

Lau C.P., Certificate Course in Recent Medical Advances for General Practitioners - Current management of atrial fibrillation, Family Medicine Unit, HKU & the Family Medicine Division, Hong Kong Sanatorium and Hospital. Hong Kong, 2004.

Lau C.P., Effect of Oral Arsentic Trioxide on QT Interval and Dynamicity in Patients with Acute Promyclocytic Leukemia, In: Siu, D., Au, W.Y., Lee, K., Yung, C.,Kwong, Y.L., Tse, H.F., Amercian College of Cardiology Foundation. 2004.

Lau C.P., Heart Rhythm Society 2005 ?Core Curriculum: CC02 Implantable Devices for Heart Failure: Where Are We Going? , Heart Rhythm Society. New Orleans, USA, 2005.

Lau C.P., Mast Cells Accumulation after Coronary Microembolization Contribute to Angiogenesis and Preserve Microvascular Function, In: Zhang, Q.Y.,Tse, H.F.,Zhang Q.G.,Ge,J.B.,Chen, J.Z., American College of Cardiology Foundation. 2004.

Lau C.P., Randomised Controlled Trail of Qigong in Hypertension, In: Cheung, B.M.Y., Lp, J.L.F., Fong, D.Y., Chan, M.Y. Wong, S.H.F., Lam, K.S.L., Wong, V.C.W., Karlberg, J.P.E., Cardiovascular Drugs and Therapy. 2004, 18(S1): A89.

Lau C.P., Teleconference & Scientific Symposium with Harvard Medical School and Stanford University Medical Centre, Hong Kong Sanatorium & Hospital. Hong Kong, 2004.

Lau C.P., The 6th Biannual Scientific Sessions & 10th Anniversary Celebrations of Chinese Society of Pacing & electrophysiology, Chinese Society of Pacing and Electrophysiology. Guilin, China, 2004.

Lau C.P., The 7th South China International Congress of Cardiology 第七屆嶺南心血管病學術會議暨南方國際心血管病論壇 ?Ablation for atrial fibrillation ?How to optimize CRT, 中華醫學會雜誌社廣東省醫學會心血管病分會廣西醫學會心血管病分會湖南省醫學會心血管病分會海南眷醫學會心血管病分會廣東省醫學會心胸外科分會廣東省介入心臟病學會廣東省醫學會心臟起搏與電生理分會廣東省護理學會心血管專業委員會香港心臟專科學院澳門心臟專科學院嶺南心血管學術會議組委會 . Guongzhou, China, 2005.

Lau C.P., The Effectiveness of a Nurse-Delivered Smoking Cessation intervention for Cardiac Patients: A Randomised Controlled Trial, In: Chan, S.C.S, Lam,T.H., The 7th Asia Pacific Conference on Tobacco or Health. Korea, 2004.

Lau C.P., The International Heart Forum Beijing 2004 ?Pacing from non-traditional sites ?Contemporary concept of CRT Therapy ?ICD Application: ICD Therapy for Prevention of SCD , National Center for Cardiovascular Diseases of China. Beijing, China, 2004.

Lau C.P., Thirteenth Annual Scientific Congress Hong Kong College of Cardiology, Hong Kong College of Cardiology. Hong Kong, 2005.

Lau C.P., Update on Endocrinology and Lipid Therapy: “ New Strategies and Targets for Lipid Therapy”, The Hong Kong College of Family Physicians. Hong Kong, 2004.

Lau C.P., “ The Role of pacing in the reduction of AF- Its relationship with patients in Heart Failure” - Asia’s “ Surround AF” Symposium , St Jude Medical. Hong Kong, 2005.

Lau C.P., “Prevention of atherosclerosis in the 21st century: What have we learned from recent clinical trials?” Joint Clinical Symposium , Research Centre on Heart, Brain, Hormone & Healthy Aging, HKU and Mayo Clinic. Hong Kong, 2004.

Lau C.P., 嶺南心血管雜誌 (英文版), 2004.

Li G.R., Sun H., Deng X. and Lau C.P., Characterization of ionic currents in human mesenchymal stem cells from bone marrow, Stem Cells. 2005, 23: 371-382.

Li G.R., Deng X., Sun H. and Lau C.P., Ion Channels And Cell Proliferation In Mesenchymal Stem Cells From Rat Bone Marrow, Biophysical Journal . 2005, 88(2/2): 547a.

Li G.R., Lau C.P., Leung T.K. and Nattel S., Ionic Current Abnormalities Associated With Prolonged Action Potentials In Cardiomyocytes From Diseased Human Right Ventricles, Heart Rhythm. 2004, 1: 460-468.

Liu H., Lau C.P. and Li G.R., EGFR protein tyrosine kinase dependent modulation of voltage-gated sodium current in guinea pig ventricular myocytes, Journal of Hong Kong College Cardiology. 2004, 12(3/4):: P14.

Man Y.B., Cheung B.M.Y., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of Hypertension in the Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong. 2004.

Sin P.Y., Tse H.F., Siu C.W., Tsang V.Y.C., Lam C.L.K. and Lau C.P., Impairment of quality-of-life in patients with atrial fibrillation. In Tse HF, Tse TF, Lau CP, Woo KS(eds), First Global Conference on Cardiovascular Clinical Trials and Pharmacotherapy - 2nd WHF Global Conference on Cardiovascular Clinical Trials and 13th International Society of Cardiovascular Pharmacotherapy Congress. Italy, Monduzzi Editore, 2005, 45-50.

Sin P.Y., Lau C.P. and Tse H.F., Quality of life in patients with atrial fibrillation., J HK Coll Cardiol. 2005, 13: 10-15.

Sin P.Y., Tse H.F., Siu C.W., Tsang V.Y.C., Lam C.L.K. and Lau C.P., Successful pulmonary vein isolation using transvenous catheter cryoablation improves quality-of-life in patients with atrial fibrillation. In Tse HF, Tse TF, Lau CP, Woo KS (eds):, First Global Conference on Cardiovascular Clinical Trials and Pharmacotherapy - 2nd WHF Global Conference on Cardiovascular Clinical Trials and 13th International Society of Cardiovascular Pharmacotherapy Congress. Italy, Monduzzi Editore, 2005, 51-56.

Siu C.W., Tse H.F., Lee K.L.F., Lam Y.M., Yung L.Y. and Lau C.P., A rapid ultrasonic cardiac output monitor method for optimization of ventriculo-ventricular interval (VVI) in cardiac resynchronization therapy., Heart Rhythm. 2005, 2: S84.

Siu C.W., Tse H.F. and Lau C.P., Inappropriate implantable cardioverter defibrillator shock from a transcutaneous muscle stimulation device therpay., J Interv Card Electrophysiol. 2005, 13(1): 73-5.

Siu C.W., Tung H.M., Lau C.P., Chu K.W., Jim M.H. and Tse H.F., Prevalence and clinical predictors for new-onset postoperative atrial fibrillation after elective abdominal surgery for colorectal cancer., Pacing Clin Electrophysiol. 2005, 28: S120-123.

Siu C.W., Chan R.H.W., Tse H.F., Lau C.P., Jim M.H., Ho H.H. and Chu F., Recurrent acute heart failure caused by sliding hiatus hernia. , Postgrad Med Journal. 2005, 81(954): 268-9.

Siu C.W., Tse H.F. and Lau C.P., Thyrotoxic Heart Disease, J HK Coll Cardiol . 2005, 13: 16-20.

Siu C.W. and Lau C.P., new advances in nonpharmacologic therapy for atrial fibrillation, Therapy 2005. 2005, 2: 311-9.

Siu D.C.H., Yeung C.Y., Kung A.W.C., Lau C.P. and Tse H.F., Prevalence, clinical characteristics and outcomes of thyrotoxic dilated cardiomyopathy as the initial presentation in patients with thyrotoxicosis, American Heart Association Annual Scientific Meeting, November 7 - 10, 2004, New Orleans, USA. 2004.

Tian M., Dong M., Chiu S.W., Lau C.P. and Li G.R., Effects Of Clotrimazole On Human Cardiac Repolarization Potassium Currents, Journal of Hong Kong College Cardiology. 2004, 12(3/4): 101(P11).

Tse H.F., Lau C.P., Tsang V.Y.C., Siu C.W., Yu C., Park E., Bornzin G.A. and Benser M.E., Blood pressure response to transition from supine to standing posture using an orthostatic response algorithm., Pacing Clin Electrophysiol. 2005, 28 Suppl 1: S242-5.

Tse H.F., Lee P.Y. and Lau C.P., Bone Marrow Cell Transplantation for Myocardial Regeneration and Therapeutic Angiogenesis., Laham R, Balm DS (eds). In. Angiogenesis and Direct Myocardial Revascularization. Totowa, NJ. Humana Press Inc, 2005, 261-281.

Tse H.F., Ripley K.L., Zhang Q., Siu C.W., Van V.L.E.E.T. .J.F. and Lau C.P., Cryothermal cooled radiofrequency ablation increases lesion size without without risk of thrombus formation., Eur Heart J 2005.

Tse H.F., Lee K.L.F., Lau C.P., Ripley K.L., Siu C.W., Van Vleet J.F. and Pelkey W.L., Effects of temporal application parameters on lesion dimensions during transvenuous catheter cryoablation, J Cardiovasc Electrophysiol. 2005, 16(2): 201-4.

Tse H.F., Lau C.P., Newman D., Ellenbogen K.A., Buhr T. and Markowitz T., Effects of ventricular rate regularization pacing on quality of life and symptoms in patients with atrial fibrillation (Atrial fibrillation symptoms medicated by pacing to mean rates [AF SYMPTOPMS study]., Am J Cardiol. 2004, 94(7): 938-41.

Tse H.F., Tse T.F., Lau C.P. and Woo K.S., First Global Conference on Cardiovascular Clinical Trials and Pharmacotherapy - 2nd WHF Global Conference on Cardiovascular Clinical Trials and 13th International Society of Cardiovascular Pharmacotherapy Congress, Monduzzi Editore, Bologna, Italy. 2005.

Tse H.F. and Lau C.P., Impact of duration of cryothermal appliation on clinical efficacy of pulmonary vein isolation using transvenous cryoablation, Pacing Clin Electrophysiol. 2005, 28: 839-43.

Tse H.F., Siu C.W., Lee K.L.F., Tang M.O., Tsang V.Y.C., Chan H.W. and Lau C.P., Incremental benefit of rate adaptive pacing onexercise performance during cardiac resynchronization therapy., Heart Rhythm. 2005, 2: S166.

Tse H.F. and Lau C.P., Prevalence and clinical implications of atrial fibrillation episodes detected by pacemaker in patients with sick sinus syndrome., Heart. 2005, 91(3): 362-4.

Tse H.F., Tsang V.Y.C., Lam C.L.K., Lau C.P., Sin P.Y. and Siu C.W., Successful pulmonary vein isolation using transvenous catheter cryoablation improves quality-of-life in patients with atrial fibrillation, Pacing Clin Electrophysiol. 2005, 28(5): 421-4.

Wang X., Fielding R., Lau C.P., Leung K.K., Shi Q.J. and Li X.Q., Scale characteristics of Chinese verions of BID-II and HADS (Abstract), 9th Research Postgraduate Symposium, 4 December 2004, Hong Kong. Hong Kong, Faculty of Medicine, University of Hong Kong, 2004, 94.

Wang Y., Dong M., Lau C.P. and Li G.R., Modulation of human Ehter-a-go-go-related potassium (hERG) channels by protein tyrosine kinases, Journal of Hong Kong College Cardiology. 2004, 12(3/4): 102(P15).

Yiu M.W.C., Ooi C.G.C., Tse H.F., Lau C.P., Leong Fung L.L.Y. and Leong Fung L.L.Y., Multi-detector row CT mapping of the left atrium and pulmonary vein for radiofrequency and cryo-ablation for atrial fibrillation:Pre-operative findings and post-operative complications., 12th Annual Scientific Meeting, Hong Kong College of Radiologists.. 2004.

Yu C.M., Lau C.P., Chau J., McGhee S.M., Kong S.L., Cheung B.M.Y. and Li L.S.W., A short course of cardiac rehabilitation program is highly cost effective in improving long-term quality of life in patients with recent myocardial infarction or percutaneous coronary intervention, Archives of Physical Medicine and Rehabilitation. 2004, 85(12): 1915-22.

Researcher : Lau G

Project Title:	Role of intrahepatic close-circular covalent (ccc) DNA in HBV reactivation in hepatitis B surface antigen positive subjects who received chemotherapy
Investigator(s):	Lau G, Liang RHS, He ML
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	11/2002

Abstract:

To study the T cell determinants of liver damages during the immune-clearance phase of chronic HBV infection.

Project Title:	Characterization of the HBV-specific cytotoxic T lymphocyte (CTL) activities associated with a sustained remission after anti-HBV therapy in Chinese with chronic HBV infection
Investigator(s):	Lau G, Lin CL, Zhang H
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2004

Abstract:

To compare the frequency and phenotype of the end-of-therapy virus-specific CD8+ T cells in chronic HBV patients who had sustained response to anti-HBV therapy with those who relapse; to compare the characteristics of end-of-therapy HBV-specific CD8+ T cells in those who were treated with nucleoside analogues, such as lamivudine, and those treated with immune therapy, such as pegylated interferon.

Project Title:	Phenotypic characteristics of virus-specific CD8+ T cells associated with sustained remission in chronic hepatitis B infection
Investigator(s):	Lau G
Department:	Medicine
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2004

Abstract:

Refer to hard copy

List of Research Outputs

Hui C.K., Lie A., Au W.Y., Leung A.Y.H., Ma S.Y., Cheung W.W., Zhang H., Chim C.S., Kwong Y.L., Liang R.H.S. and Lau G., A long-term follow-up study on hepatitis B surface antigen-positive patients undergoing allogeneic hematopoietic stem cell transplantation, Blood. 2005, 106: 464-9.

Hui C.K. and Lau G., Advances in immunomodulating therapy of HBV infection, Int J Med Sci. 2005, 2: 24-29.

Hui C.K., Bowden S., Jackson K., Au W.Y., Fong D.Y.T., Lie A.K.W., Chim J.C.S., Liang R.H.S. and Lau G., Clinical significance of intrahepatic hepatitis B virus covalently closed circular DNA in chronic hepatitis B patients who received cytotoxic chemotheraphy, Blood. 2005, 105(6): 2616-2617.

Hui C.K., Lie A.K.W., Au W.Y., Ma S.Y., Leung A.Y.H., Zhang H., Sun J.Z., Cheung W.W.W., Chim J.C.S., Kwong Y.L., Liang R.H.S. and Lau G., Effectiveness of prophylactic Anti-HBV therapy in allogeneic hematopoietic stem cell transplantation with HBsAg positive donors, American Journal of Transplantation. 2005, 5(6): 1437-45.

Hui C.K., Zhang H. and Lau G., Management of chronic hepatitis B in treatment-experienced patients, Gastroenterol Clin North Am. 2004, 33: 601-16.

Hui C.K., Sun J., Au W.Y., Lie A.K.W., Yueng Y.H., Zhang H., Lee N.P., Hou J., Liang R.H.S. and Lau G., Occult hepatitis B virus infection in hematopoietic stem cell donors in a hepatitis B virus endemic area, Journal of Hepatology. 2005, 42(6): 813-9.

Hui C.K., Cheung B.M.Y. and Lau G., Pharmacokinetics of pitavastatin in subjects with Child-Pugh A and B cirrhosis, Br J Clin Pharmacol. 2005, 59: 291-7.

Hui C.K., Yu J., Au W.Y., Zhang H., Bartholomeusz A., Locarnini S., Kwong Y.L., Liang R.H.S. and Lau G., Sexual transmission of hepatitis B infection despite the presence of hepatitis B virus immunity in recipients of allogeneic bone marrow transplantation, J Clin Virol. 2005, 32: 173-8.

Lau G., Piratvisuth T., Luo K.X., Marcellin P., Thongsawat S., Cooksley G., Gane E., Fried M.W., Chow W.C., Paik S.W., Chang W.Y., Berg T., Flisiak R., McCloud P. and Pluck N., Peginterferon Alfa-2a, lamivudine, and the combination for HBeAg-positive chronic hepatitis B, N Engl J Med. USA, The Massachusetts Medical Society, 2005, 352: 2682-95.

Lau G., Treatment of immunosuppressed chronic hepatitis B patients, Med J Malaysia. 2005, 60: 57-62.

Liaw Y.F., Leung N., Guan R., Lau G., Merican I., McCaughan G., Gane E. and Kao J.H., Asian-Pacific Consensus statement on the management of chronic hepatitis B: A 2005 update, Liver International. 2005, 25(2): 472-89.

Liaw Y.F., Leung N., Guan R., Lau G., Merican I., McCaughan G., Gane E., Kao J.H. and Omata M., Asian-Pacific consensus statement on the management of chronic hepatitis B: a 2005 update, Liver Int. 2005, 25: 472-89.

Lin M.C., Lee N., Zheng N., Yang P.H., Wong O.G., Kung H.F., Luk J.M.C. and Lau G., Tumor necrosis factor-alpha-induced protein 1 and immunity to hepatitis B virus, World J Gastroenterol. 2005.

Lo C.M., Fan S.T., Liu C.L., Yong B.H., Wong Y., Lau G., Lai C.L., Ng I.O.L. and Wong J., Lessons learned from one hundred right lobe living donor liver transplants, Annals of Surgery. 2004, 240(1): 151-158.

Lo C.M., Liu C.L., Lau G., Chan S.C., Ng I.O.L., Fan S.T. and Wong J., Liver transplantation for chronic hepatitis B with lamivudine-resistant YMDD mutant using add-on adefovir dipivoxil to lamivudine (Abstract), American Journal of Transplantation. 2005, 5(Suppl): 180.

Lo C.M., Liu C.L., Lau G., Chan S.C., Ng I.O.L., Fan S.T. and Wong J., Liver transplantation for chronic hepatitis B with lamivudine-resistant YMDD mutant using add-on adefovir dipivoxil to lamivudine (Poster Presentation), American Transplant Congress, Seattle, U.S.A., 21-25 May 2005.

Luk J.M.C., Wang P., Wang J., Lau G. and Fan S.T., Hepatocyte-like phenotypes of bone marrow stromal cells after co-culture with damaged liver tissues and intraportal transplantation in cirrhotic liver (Abstract), The 55th Annual Meeting of the American Association for the Study of Liver Diseases, Boston, USA, 29 October – 2 November 2004.

Luk J.M.C., Lee C.K.F., Su Y.C.F., Lam C.T., Hu M.Y., He Q., Lau G., Wong W.S. and Fan S.T., Proteomic identification of Ku70/Ku80 autoantigen recognized by monoclonal antibody against hepatocellular carcinoma (Abstract), HUPO 3rd Annual World Congress, Beijing, China, 25-27 October 2004.

Luk J.M.C., Su Y.C.F., Lam C.T., Lee C.K.F., Hu M.Y., He Q., Lau G., Wong F.W.S. and Fan S.T., Proteomic identification of Ku70/Ku80 autoantigen recognized by monoclonal antibody against hepatocellular carcinoma, Proteomics. 2005, 5(7): 1980-1986.

Luo Y., Lo C.M., Cheung C.K.Y., Lau G. and Fan S.T., Identification of hepatitis B virus specific lymphocytes in human liver allografts from hepatitis B virus immune donors (Abstract), The 6th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 8 January 2005.

Luo Y., Lo C.M., Cheung C.K.Y., Lau G., Fan S.T. and Wong J., Potential role of resident intrahepatic lymphocytes in adoptive transfer of immunity to hepatitis B virus through liver transplantation (Poster Presentation), Digestive Disease Week, Chicago, U.S.A., 14-19 May 2004.

Ma S.Y., Au W.Y., Lie A.K., Ng I.O.L., Leung A.Y.H., Tse E.W.C., Liang R.H.S., Lau G. and Kwong Y.L., Liver graft-versus-host disease after donor lymphocyte infusion for relapses of hematologic malignacies post allogeneic hematopoietic stem cell transplantation, Bone Marrow Transplant. 2004, 34: 57-61.

Marcellin P., Mommeja-Marin H., Sacks S.L., Lau G., Sereni D., Bronowicki J.P., Conway B., Trepo C., Blum M.R. and Yoo B.C., A phase II dose-escalating trial of clevudine in patients with chronic hepatitis B, Hepatology. 2004, 40: 140-8.

Marcellin P., Lau G., Bonino F., Farci P., Hadziyannis S., Jin R., Lu Z.M., Piratvisuth T., Germanidis G. and Yurdaydin C., Peginterferon alfa-2a alone, lamivudine alone, and the two in combination in patients with HBeAg-negative chronic hepatitis B, N Engl J Med. 2004, 351: 1206-17.

Ng S.M., Gao Y., Lum C.T., Yang Z.F., Huang J., Lau G., Fan S.T., Kung H. and Lin M.C., Novel gene therapy by rAAV-mediated transfer of human TERTC27 polypeptide in human and rat hepatocellular carcinomas, American Association for Cancer Research Meeting. 2004.

Ng S.S., Gao Y., Lum C.T., Yang Z., Huang J., Lau G., Fan S.T., Kung H. and Lin M.C., Novel HCC gene therapy by rAAV-mediated transfer of human TERTC27 polypeptide in human and rat hepatocellular carcinoma (Abstract), Asian Journal of Surgery. 2005, 28(Suppl 2): S99.

Ng S.S., Gao Y., Lum C.T., Yang Z., Lau G., Fan S.T., Kung H. and Lin M.C., rAAV-mediated long-term expression of endostatin significantly inhibits the progression of HCC (Abstract), Asian Journal of Surgery. 2005, 28(Suppl 2): S100.

Ng S.S., Gao Y., Lum C.T., Yang Z., Lau G., Fan S.T., Kung H. and Lin M.C., rAAV-mediated long-term expression of endostatin significantly inhibits the progression of HCC (Abstract), The 4th International Meeting on Hepatocellular Carcinoma: Eastern and Western Experiences, Hong Kong, 14-16 December 2004.

Vandepapeliere P., Lau G., Leroux-Roels G., Horsmans Y., Wettendorff M. and Ferrari C., A randomized controlled trial comparing therapeutic vaccination plus lamivudine with lamivudine only in HBeAg-positive chronic hepatitis B patients , Hepatology. 2005, in press.

Wang P.P., Wang J.H., Yan Z.P., Hu M., Lau G., Fan S.T. and Luk J.M.C., Expression of hepatocyte-like phenotypes in bone marrow stromal cells after HGF induction, Biochemical and Biophysical Research Communications. 2004, 320(3): 712-716.

Zhang H.Y., Nanji A.A., Luk J.M.C., Huang X.R., Lo C.M., Chen Y.X., Yuen S.T., Lan H.Y. and Lau G., Macrophage migration inhibitory factor expression correlates with inflammatory changes in human chronic hepatitis B infection, Liver International. 2005, 25(3): 571-579.

Researcher : Lau GKK

Project Title:	Role of intrahepatic close-circular covalent (ccc) DNA in HBV reactivation in hepatitis B surface antigen positive subjects who received chemotherapy
Investigator(s):	Lau G, Liang RHS, He ML
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	11/2002

Abstract:

To study the T cell determinants of liver damages during the immune-clearance phase of chronic HBV infection.

Project Title:	Characterization of the HBV-specific cytotoxic T lymphocyte (CTL) activities associated with a sustained remission after anti-HBV therapy in Chinese with chronic HBV infection
Investigator(s):	Lau G, Lin CL, Zhang H
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2004

Abstract:

Project Title:	Phenotypic characteristics of virus-specific CD8+ T cells associated with sustained remission in chronic hepatitis B infection
Investigator(s):	Lau G
Department:	Medicine
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2004

Abstract:

Refer to hard copy

List of Research Outputs

Researcher : Lau HL

List of Research Outputs

Jin L., Lau H.L., Smith D.K., Lau K.S., Cheung P.T., Kwan E.Y.W., Low L.C.K. and Kung A.W.C., A family with osteoporosis-pseudoglioma syndrome (OPG) due to compound heterozygous mutation of the LRO5 gene, 26th Annual Meeting of the American Society for Bone & Mineral Research, October 1-5, 2004, Seattle, USA. Journal of Bone and Mineral Research . 2004, 19(Supl 1): SA125.

Jin L., Lau H.L., Smith D.K., Lau K.S., Cheung P.T., Kwan E.Y.W., Low L.C.K., Chan V.N.Y. and Kung A.W.C., A family with osteoporosis-pseudoglioma syndrome (OPG) due to compound heterozygous mutation of the LRP5 gene, HKU 10th Medical Research Conference. 2005.

Jin L., Lau H.L., Smith D.K., Lau K.S., Cheung P.T., Kwan E.Y.W., Low L.C.K., Chan V.N.Y. and Kung A.W.C., Family with osteoporosis Pseudolioma Syndrome due to compound heterozygosity of two novel mutations of the LRP5 gene, 6th Regional Osteoporosis Conference, 21-22 May 2005, Hong Kong. 2005.

Kung A.W.C., Lai M.H., Lau H.L. and Chan V.N.Y., Polymorphisms in the promoter region of the estrogen receptor beta gene are associated with higher risks of osteoporosis in both men and women, Osteoporosis Global Conference, 2nd Joint Meeting of European Calcified Tissue and International Bone & Mineral Society, 25-29 June 2005, Geneva, Switzerland. 2005.

Kung A.W.C., Lau H.L., Paterson A.D., Cheung W.M.W., Luk K.D.K. and Chan V.N.Y., Test of linkage and/or association of genes and bone mineral density in Chinese, 26th Annual Meeting of the American Society for Bone & Mineral Research, October 1-5, 2004, Seattle, USA. Journal of Bone and Mineral Research. 2004, 19(Supl 1): SU159.

Lai M.H., Lau H.L., Chan V.N.Y. and Kung A.W.C., Estrogen receptor beta gene polymorphisms in the promoter region are associated with higher risks of osteoporosis in both men and women, The Endocrine Society’s 87th Annual Meeting, June 4-7, 2005, San Diego, USA. 2005.

Lai M.H., Lau H.L., Chan V.N.Y. and Kung A.W.C., Polymorphisms in the promoter region of the estrogen receptor beta gene are associated with higher risks of osteoporosis in both men and women, HKU 10th Medical Research Conference. 2005.

Lai M.H., Lau H.L., Chan V.N.Y. and Kung A.W.C., Promoter polymorphisms of the estrogen receptor beta gene are associated with higher risks of osteoporosis in both men and women, 6th Regional Osteoporosis Conference, 21-22 May 2005, Hong Kong. 2005.

Lau H.L., Ng M.Y.M., Ho A.Y.Y., Luk K.D.K. and Kung A.W.C., Genetic and environmental determinants of bone mineral density in Chinese women, 26th Annual Meeting of the American Society for Bone & Mineral Research, October 1-5, 2004, Seattle, USA. Journal of Bone and Mineral Research. 2004, 19(Supl 1): M161.

Lau H.L., Ng M.Y.M., Ho A.Y.Y., Luk K.D.K. and Kung A.W.C., Genetic and environmental determinants of bone mineral density in Chinese women, Bone. 2005, 36(4): 700-9.

Researcher : Lau KS

List of Research Outputs

Jin L., Lau H.L., Smith D.K., Lau K.S., Cheung P.T., Kwan E.Y.W., Low L.C.K. and Kung A.W.C., A family with osteoporosis-pseudoglioma syndrome (OPG) due to compound heterozygous mutation of the LRO5 gene, 26th Annual Meeting of the American Society for Bone & Mineral Research, October 1-5, 2004, Seattle, USA. Journal of Bone and Mineral Research . 2004, 19(Supl 1): SA125.

Jin L., Lau H.L., Smith D.K., Lau K.S., Cheung P.T., Kwan E.Y.W., Low L.C.K., Chan V.N.Y. and Kung A.W.C., A family with osteoporosis-pseudoglioma syndrome (OPG) due to compound heterozygous mutation of the LRP5 gene, HKU 10th Medical Research Conference. 2005.

Jin L., Lau H.L., Smith D.K., Lau K.S., Cheung P.T., Kwan E.Y.W., Low L.C.K., Chan V.N.Y. and Kung A.W.C., Family with osteoporosis Pseudolioma Syndrome due to compound heterozygosity of two novel mutations of the LRP5 gene, 6th Regional Osteoporosis Conference, 21-22 May 2005, Hong Kong. 2005.

Researcher : Lau WCS

Project Title:	Prospective study of the clinical pattern of systemic lupus erythematosus in Hong Kong
Investigator(s):	Lau WCS
Department:	Medicine
Source(s) of Funding:	Other Funding Scheme
Start Date:	01/1993

Abstract:

To study the clinical pattern of systemic lupus erythematosus in Hong Kong.

Project Title:	Effects of sex hormones on lymphocyte function in systemic lupus erythematosus
Investigator(s):	Lau WCS, Mok TMY
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002

Abstract:

To examine the effects of estrogen, testrogen, testosterone and prolactin on SLE peripheral T- and B-lymphocyte apoptosis and function. Menstruating and postmenopausal female patients and male patients will be studied.

Project Title:	A study to evaluate the immunopathology of Severe Acute Respiratory Syndrome
Investigator(s):	Lau WCS, Chan EYT, Cheung BMY
Department:	Medicine
Source(s) of Funding:	VCO SARS Research Fund
Start Date:	07/2003

Abstract:

To investigate the time course of changes in cytokines in patients with SARS; to investigate the relationship between clinical deterioration and changes in the serum/plasma levels of cytokines; to evaluate the cytokine expression in post-mortem lung tissues of patients with SARS will be studied.

Project Title:	Osteopontin and rheumatoid arthritis
Investigator(s):	Lau WCS, Chiu PKY, Tsang KWT, Tang WM, Fung PCW
Department:	Medicine
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2003

Abstract:

To confirm that OPN expression is increased in rheumatoid synovium; to determine if T cell activation is associated with increased OPN synthesis; to study the effects of macrophage derived cytokines and IL-10, an anti-inflammatory cytokine, on synovial cell OPN expression; to evaluate the effects of OPN on rheumatoid synovial cell function, including free radical production, cytokine production and MMP expression.

Project Title:	Evaluation of the effects of sex hormones on neutrophils and macrophage apoptosis and macrophage phagocytic clearance of apoptotic neutrophils in systemic lupus erythematosus
Investigator(s):	Lau WCS
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Abstract:

To study the effects of oestrogen and progesterone on the rate of apoptosis and secondary necrosis of PMN and M[phi] in SLE patients and controls; to study the effects of oestrogen and progesterone on the ability of phagocytic M[phi] to clear apoptotic bodies in patients with SLE and controls.

Project Title:	Complement deficiency and dendritic cell function in the pathogenesis of systemic lupus erythematosus
Investigator(s):	Lau WCS
Department:	Medicine
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	10/2004

Abstract:

To determine their phenotypic expression i.e. stage of maturity; to study their functional activity through intracellular cytokine detection; to study their capability to phagocytose apoptotic cells and their subsequent functional changes; to evaluate the effects of various complement factors including C1q, C2, C3, C4 and mannose binding lectin on their uptake of apoptotic cells; to determine their interactions with T-cells following ingestion of apoptotic cells and to delineate the subsequent changes in T-cell activity through intracellular cytokine detection.

Project Title:	Complement deficiency and dendritic cell function in the pathogenesis of systemic lupus erythematosus
Investigator(s):	Lau WCS
Department:	Medicine
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

Refer to hard copy

List of Research Outputs

Chong W.P., Ip E.W.K., Wong W.H.S., Lau W.C.S., Chan T.M. and Lau Y.L., Association of interleukin-10 promoter polymorphisms with systemic lupus erythematosus, Genes and Immunity. Nature Publishing Group, 2004, 5: 484-492.

Chu M.Y., Wong R.W.S., Ho R., Yeung D., Lau S.K., Kwong E. and Lau W.C.S., Utilisation of the Chinese arthritis impact measurement scales-2 (CAIMS-2): capturing clinical status changes in patients with rheumatoid arthritis (RA), 11th APLAR Bi-annual Congress, Jeju, Korea 11-16 September 2004.

Chu M.Y., Chiu P.K.Y., Cheng I., Tang W.M. and Lau W.C.S., Utilisation of the Chinese arthritis impact measurement scales-2 short form (CAIMS-2 SF) in detecting clinical status changes in osteoarthritis (OA) patients who participated in a clinical trial of green-lipped mussel extracts, 11th APLAR Bi-annual Congres, Jeju, Korea 11-16 September 2004.

Jin O., Sun L.Y., Zhou K.X., Zhang X.S., Feng X.B., Mok T.M.Y. and Lau W.C.S., Lymphocyte apoptosis and macrophage function: correlation with disease activity in systemic lupus erythematosus, Clinical Rheumatology. 2005, 24: 107-110.

Jin O., Chan W.K., Mok T.M.Y., Sun L.Y. and Lau W.C.S., Osteopontin (OPN), matrix metalloproteinase (MMP)-3 and lupus nephritis (LN), 11th APLAR Bi-annual Congress, Jeju, Korea 11-16 September 2004.

Kim D.L., Wong R.W.S., Jones B.M., Lau W.C.S. and Kim T.Y., Antiperinuclear factor in Chinese: does antiperinuclear factor have the same implication in Chinese and Western populations?, 11th APLAR Bi-annual Congress, Jeju, Korea 11-16 September 2004.

Kong K.P., Prokunina-Olsson L., Wong W.H.S., Lau W.C.S., Chen T.M., Alarcon-Riquelme M. and Lau Y.L., A New Haplotype of PDCD1 is Associated with Rheumatoid Arthritis in Hong Kong Chinese, Arthritis & Rheumatism. 2005, 52(4): 1058-1062.

Kong K.P., Prokunina L., Wong W.H.S., Lau W.C.S., Chan T.M., Alarcon-Riquelme M.E. and Lau Y.L., Association of the PD-1 Gene (PDCD1) Polymorphisms with Systemic Lupus Erythematosus and Rheumatoid Arthritis, Ruby Jubilee Scientific Meeting, HK, 24-26 Sepember 2004 (Abstract in Hong Kong Journal of Paediatrics (new series). Hong Kong, Medcom Limited, 2004, 9 (suppl): 47.

Kumana C.R., Cheung G.T.Y. and Lau W.C.S., Severe digital ischaemia treated with phosphodiesterase inhibitors, Annals of Rheumatic Diseases. 2004, 63: 1522-1524.

Kumar S., Cheung H.Y., Lau W.C.S., Chen S.F. and Hyde K.D., In vitro studies of endophytic fungi from Tripterygium wilfordii with anti-proliferative activity on human peripheral blood mononuclear cells, Journal of Ethnopharmacology. 2004, 94: 295-300.

Lau W.C.S., A New Model of Health Identified through Qualitative and Quantitative Analysis of the Chinese Arthritis Impact Measurement Scales 2. Cultural Issues in the Translation and Validation of Status Measures, 8th Medical Research Conference, Department of Medicine, The University of Hong Kong, January 2003. 2004.

Lau W.C.S., A Randomised Controlled Study on the Rehabilitation of Rheumatoid Arthritis Patients with the Use of Psychological and Occupational Therapy, 8th Medical Research Conference, Department of Medicine, The University of Hong Kong, January 2003. 2004.

Lau W.C.S., A new approach in joints healthcare, Blackmores. 2005.

Lau W.C.S., A new approach in joints healthcare, Blackmores, 22 January 2005. 2005.

Lau W.C.S., An overview of the pathogenesis and treatment of pulmonary hypertension: Part 2, Hong Kong Bulletin on Rheumatic Diseases. 2005, 4(2): 50-53.

Lau W.C.S., Antirheumatic Drug Prescribing Pattern: A Survey of Hong Kong Physicians, 8th Medical Research Conference, Department of Medicine, The University of Hong Kong, January 2003. 2004.

Lau W.C.S., Chung E.K., Zhou B., Wu Y.L., Yang Y., Mok T.M.Y., Ip E.W.K., Wong W.H.S., Lau Y.L. and Yu C.Y., C4A gene deficiency in Chinese patients with systemic lupus erythematosus (SLE), 11th APLAR Bi-annual Congress, Jeju, Korea 11-16 September 2004.

Lau W.C.S., Current status in the medical treatment of osteoarthritis, The First Hong Kong International Orthopaedic Forum, 24-25 April 2004. 2004.

Lau W.C.S., Diagnosis and early treatment of common arthritis, Solar-Med Limited and Genzyme Corporation Limited, 15 September 2003. 2004.

Lau W.C.S., Yeung J.S.L., Chan W.K. and Ren Y., Diminished macrophage (Mac) clearance of apoptotic polymorphonuclear cells (PMN) in patients with rheumatoid arthritis (RA), 11th APLAR Bi-annual Congress, Jeju, Korea 11-16 Septemer 2004.

Lau W.C.S., Chung E.K., Zhou B., Wu Y.L., Yang Y., Mok T.M.Y., Ip E.W.K., Wong W.H.S., Lau Y.L. and Yu C.Y., Genotypic and phenotypic analyses of C4A and C4B in Chinese patients with systemic lupus erythematosus (SLE), 11th APLAR Bi-annual Congress, Jeju, Korea 11-16 September 2004.

Lau W.C.S., International perspective and HKU - Assessment: UK perspective similarities and diferences with the HKU curriculum, Frontiers in Biomedical Reserach, Faculty of Medicine, The University of Hong Kong 2003, 12 December 2003. 2004.

Lau W.C.S., Leflunomide (LEF) Versus Low Dose Methotrexate (MTX) in Adult Asian Patients with Active Rheumatoid Arthritis (RA), 8th Medical Research Conference, Department of Medicine, The University of Hong Kong, January 2003. 2004.

Lau W.C.S., Logical emergencies, 16th Annual Scientific Meeting, Hong Kong Society of Rheumatology, 9 November 2003. 2004.

Lau W.C.S., Novel disease modifying anti-rheumatic drugs and biologic agents for rheumatoid arthritis, Symposium on Advancement of Rheumatoid Arthritis, School of Chinese Medicine of Hong Kong Baptist University, 27 September 2004. 2004.

Lau W.C.S., Novel therapies for osteoarthritis, 6th Malaysia/Singapore Workshop in Rheumatology (jointly organised by MSD Malaysia & the Malaysian Society of Rheumatology), Penang, Malaysia, 16-18 July 2004. 2004.

Lau W.C.S., Novel therapies for osteoarthritis, Hong Kong Medical Forum, Department of Medicine, Faculty of Medicine, The University of Hong Kong, 5-7 July 2003. 2004.

Lau W.C.S., Office Rheumatology: Soft Tissue Rheumatism, Annual Scientific Meeting, Hong Kong Society of Rheumatology, 10 November 2002. 2004.

Lau W.C.S., Osteoarthritis and musculoskeletal disorders in the elderly, HKU - Master of Medical Sciences (Geriatric Medicine 2004-05), specialised modules in Geriatic Medicine, 1st semester, 18 September 2004. 2004.

Lau W.C.S., Osteoarthritis in Asia - Hong Kong / China / Experience, Singapore International Scientific Meeting on Arthritis & Rheumatology 2004 / 20th Anniversary of the National Arthritis Foundation, Singapore November 2004.

Lau W.C.S., Plenary lecture: The difficult lupus - Pathogenesis of SLE "Defective apoptotic cell clearance and systemic lupus erythematosus, 11th APLAR Bi-annual Congress, Jeju, Korea, 11-16 September 2004.

Lau W.C.S., Recent advances in medical treatment of rheumatoid arthritis, 2005 Annual Congress of the Hong Kong Society for Surgery of the Hand, 21-22 May 2005. 2005.

Lau W.C.S., Rheumatic disease and the eye, Annual Scientific Meeting, Hong Kong Ophthalmological Symposium 2003, 13-14 December 2003. 2004.

Lau W.C.S., Rheumatoid arthritis, Carnation Women's Association, 19 June 2004. 2004.

Lau W.C.S., SLE and Connective Tissue Diseases, Certificate Course on Rheumatology, The Federation of Medical Societies of Hong Kong, 18 September 2002. 2004.

Lau W.C.S., Sclerosis, Regeneration Society Ltd, 7 August 2004. 2004.

Lau W.C.S., Sports Medicine and Pharmacology, The Chinese University of Hong Kong, Prince of Wales Hospital, 1 February 2005. 2005.

Lau W.C.S., The rheumatologist's perspective on recent coxib's story: weighing the risks and benefits of coxibs and NSAIDs?, CME Meeting for Physicians, St Teresa's Hospital, 14 June 2005. 2005.

Lau W.C.S., Treatment of difficult SLE, 11th APLAR Bi-annual Congress, Jeju, Korea, 11-16 September 2004.

Lau W.C.S., Treatment of knee osteoarthritis (OA) with Lyprinol, lipid extract of the green-lipped mussel - a double-blind placebo-controlled study, 9th Medical Research Conference, The University of Hong Kong, 7-8 February 2004. 2004.

Lau W.C.S., Chiu P.K.Y., Chu M.Y., Cheng I.Y.W., Tang W.M., Man R.Y.K. and Halpern G.M., Treatment of knee osteoarthritis with Lyprinol, lipid extract of the green-lipped mussel - a double-blind placebo-controlled study, Progress in Nutrition. 2004, 6(1): 17-31.

Lau W.C.S., Treatment options for common rheumatic disorders, 6th Malaysia/Singapore Workshop in Rheumatology (jointly organised by MSD Malaysia & the Malaysian Society of Rheumatology), Penang, Malaysia, 16-18 July 2004. 2004.

Lau W.C.S., Use of Health Status Measurement Scales Among Arthritis Patients With Low Educational Level, 8th Medical Research Conference, Department of Medicine, The University of Hong Kong, January 2003. 2004.

Lau W.C.S., Utilisation of the Chinese arthritis impact measurement scales-2 (CAIMS-2): clinical status changes in osteoarthritis (OA) patients who underwent total joint replacement (TJR), American College of Rheumatology (ACR/ARHP) Annual Scientific Meeting, San Antonio, Texas, USA 16-21 October 2004.

Lok-Chu E.M.Y., Chiu P.K.Y., Wong R.W.S., Tang W.M., Tang W.M. and Lau W.C.S., Translation and validation of arthritis impact measurement scales 2 into Chinese: CAIMS2, Arthritis Care & Research. 2004, 51(1): 20-27.

Mok C.C., Ying K.Y., Tang S.C.W., Leung C.Y., Lee K.W., Ng W.L., Wong R.W.S. and Lau W.C.S., Predictors and outcome of renal flares after successful cyclophosphamide treatment for diffuse proliferative lupus glomerulonephritis. , Arthritis & Rheumatism. 2004, 50: 2559-2568.

Mok C.C., Ying K.Y., Lau W.C.S., Yim C.W., Ng W.L., Wong R.W.S. and Au T.C., Treatment of pure membranous lupus nephropathy with prednisone and azathiporine: an open-label trial, American Journal of Kidney Disease. 2004, 43(2): 269-76.

Mok M.Y., JacK D.L., Lau W.C.S., Fong D.Y.T., Turner M.W., Isenberg D.A. and Lydyard P.M., Antibodies to mannose binding lectin in patients with systemic lupus erythmatosus, Lupus. 2004, 13: 522-528.

Mok T.M.Y., Chan E.Y.T., Lo Y., Wong R.W.S. and Lau W.C.S., Antiphospholipid (aPL) antibody profiles in Chinese patients with systemic lupus erythematosus, 11th APLAR Bi-annual Congress, Jeju, Korea 11-16 September 2004.

Mok T.M.Y., Chan E.Y.T., Fong D.Y.T., Leung K.F.S., Wong W.S. and Lau W.C.S., Antiphospholipid Antibody Profiles and Their Clinical Associations in Chinese Patients with Systemic Lupus Erythematosus, The Journal of Rheumatology. 2005, 32 (4): 622-8.

Mok T.M.Y., Leung P.Y., Lao T.T.H., Lo Y., Chan D.T.M., Wong R.W.S. and Lau W.C.S., Clinical predictors of fetal and maternal outcome in Chinese patients with systemic lupus erythematosus, 11th APLAR Bi-annual Congress, Jeju, Korea 11-16 September 2004.

Mok T.M.Y., Leung P.Y., Lao T.T.H., Lo Y., Chan D.T.M., Wong W.S. and Lau W.C.S., Clinical predictors of fetal and maternal outcome in Chinese patients with systemic lupus erythematosus, Annals Of The Rheumatic Diseases. 2004, 63: 1705-1706.

Mok T.M.Y., Lo Y., Leung P.Y. and Lau W.C.S., Pregnancy outcome in patients with adult onset Still's disease, Journal of Rheumatology. 2004, 31(11): 2307-2309.

Mok T.M.Y., Lo Y., Chan D.T.M., Wong R.W.S. and Lau W.C.S., Tuberculosis in systemic lupus erythematosus in an endemic area and the role of isoniazid prophylaxis during corticosteroid therapy. , Journal of rheumatology. 2005, 32(4): 609-615.

To C.H., Mok C.C., Ying K.Y., Ng W.L., Lee K.W., Wong R.W.S. and Lau W.C.S., Effect of the route of CYC administration on its efficacy and toxicities in the treatment of severe lupus nephritis, 11th APLAR Bi-annual Congress, Jeju, Korea 11-16 September 2004.

Woo J., Lau E..., Lee P., Kwok T..., Lau W.C.S., Chan C., Chiu P.K.Y., Li E..., Sham A.S.K. and Lam D..., Impact of osteoarthritis on quality of life in a Hong Kong Chinese population, Journal of Rheumatology. 2004, 31: 2433-2438.

Researcher : Lauder IJ

List of Research Outputs

Cheung B.M.Y., Lauder I.J. and Kumana C.R., Meta-analysis of Large Randomised Controlled Trials to Evaluate the Impact of Statins on Cardiovascular Outcomes, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong. 2004.

Researcher : Law CY

List of Research Outputs

Cheung B.M.Y., Lam T.H., Lam K.S.L., Tam S., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Man Y.B., Cheng C.H., Kumana C.R. and Lau C.P., Follow Up of the Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., High Blood Pressure is Related to Obesity in Hong Kong, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Lipid Profile of the Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Obesity in the Hong Kong Cardiovascular Risk Factor Prevalence Survey-2 (CRISPS2) Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of Diabetes Mellitus (DM) in the Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Law C.Y., Ho G.Y.Y., McGhee S.M., Man Y.B., Ng P.P.Y., Kumana C.R. and Lau C.P., Randomised Controlled Trial of Low Salt Diet Versus Drug Treatment in the Management of Mild hypertension, 8th Scientific Meeting of the Hong Kong Pharmacology Socieity in Association with the Shanghai Pharmacology Society, Hong Kong 2004.

Cheung B.M.Y., Law C.Y., Ho G.Y.Y., McGhee S.M., Man Y.B., Ng P.P.Y., Kumana C.R. and Lau C.P., Randomsed Controlled Trial of Low Salt Diet Versus Drug Treatment in Hypertension, Cardiovasc Drugs Thera. 2004, 18 (Suppl) 1: 15.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Relationship Between Hypertension and Obesity in Hong Kong, 3rd Asian-Pacific Congress on Hypertension, Singapore 2004.

Cheung B.M.Y., Law C.Y., McGhee S.M., Ng P.P.Y., Kumana C.R. and Lau C.P., The Relationship Between Sodium and Blood Pressure in Hong Kong Chinese, Clin Res Regul Aff. 2004, 21(2): 145-154.

Man Y.B., Cheung B.M.Y., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of Hypertension in the Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong. 2004.

Researcher : Law KW

List of Research Outputs

Mak J.C.W., Leung C.M., Ho S.P., Law K.W., Tsang K.W.T., Lam W.K., Ip M.S.M. and Chan M.M.W., Genetic susceptibility of transforming growth factor beta-1 common polymorphisms to Chinese patients with asthma, American Thoracic Society International Conference, San Diego, USA. May 2005. Proceedings of the American Thoracic Society. 2005, p.A78.

Mak J.C.W., Ho J.C.M., Ho S.P., Leung C.M., Law K.W., Ip M.S.M. and Chan M.M.W., Polymorphisms of superoxide dismutase and catalase genes and their functional activity levels in Chinese patients with asthma, American Thoracic Society International Conference, San Diego, USA. May 2005. Proceedings of the American Thoracic Society . 2005, p.A78.

Wang J., Law K.W., Ip M.S.M., Wu A.Y.Y., Wong M.K., Lam B., Chow K.M. and Chan M.M.W., Effect of asthma self management programme on asthma morbidity and health care utilization in adult patients admitted to hospital with acute asthma in Hong Kong: A randomized controlled trial, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A91.

Researcher : Lee KLF

List of Research Outputs

Siu C.W., Tse H.F., Lee K.L.F., Lam Y.M., Yung L.Y. and Lau C.P., A rapid ultrasonic cardiac output monitor method for optimization of ventriculo-ventricular interval (VVI) in cardiac resynchronization therapy., Heart Rhythm. 2005, 2: S84.

Tse H.F., Lee K.L.F., Lau C.P., Ripley K.L., Siu C.W., Van Vleet J.F. and Pelkey W.L., Effects of temporal application parameters on lesion dimensions during transvenuous catheter cryoablation, J Cardiovasc Electrophysiol. 2005, 16(2): 201-4.

Tse H.F., Siu C.W., Lee K.L.F., Tang M.O., Tsang V.Y.C., Chan H.W. and Lau C.P., Incremental benefit of rate adaptive pacing onexercise performance during cardiac resynchronization therapy., Heart Rhythm. 2005, 2: S166.

Researcher : Leung AYH

Project Title:	Adoptive transfer of cellular immunity to herpes zoster in BMT patients by vaccinating their seropositive donors with live-attenuated varicella zoster vaccine
Investigator(s):	Leung AYH, Liang RHS
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002
Completion Date:	10/2004

Abstract:

To prevent HZ infection in BMT patients, thereby reducing hospital admissions and preventing secondary complications in this group of patients.

Project Title:	Ex-vivo expansion of haematopoietic stem cells derived from human umbilical blood with special reference to the effects of all-trans retinoic acid (ATRA)
Investigator(s):	Leung AYH, Liang RHS
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Abstract:

To investigate if ATRA can stimulate expansion of primitive HSC in-vitro, characterized by an increase in scid repopulation; to see if the effects of ATRA are dependent on the presence of stromal feeders; to study the molecular mechnaisms underlying the effects of ATRA on haematopoietic stem/progenitor cells.

Project Title:	A study of normal and deregulated haematopoiesis in zebrafih, with special reference to the role of BMP signaling in haematopoietic stem cell proliferation
Investigator(s):	Leung AYH, Liang RHS, Kung H
Department:	Medicine
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	07/2004

Abstract:

To characterize the cellular features of expanded haematopoietic cells, i.e. do they contain HSC or lineage-committed progenitors or do they contain both? to understand the key signal(s) that drive(s) haematopoietic cell proliferation in the developing embryos in relation to a heightened BMP signaling due to reduced antagonism by chordin.

Project Title:	Function of survivin during embryonichemoatopoiesis and vascular formation in a zebrafish model
Investigator(s):	Leung AYH
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Abstract:

To characterize the spatial and temporal expression of survivin in normal zebrafish embryos: is survivin expressed exclusively in hematopoietic or vascular tissues or is it expressed in both tissues? To investigate the effects of survivin knock-down in wild-type zebrafish embryos using anti-sense morpholino and dominant negative survivin mRNA injection: what would be the effect(s) on primitive hematopoiesis, vasculogenesis and angiogenesis?

Project Title:	A study of normal and deregulated haematopoiesis in zebrafih, with special reference to the role of BMP signaling in haematopoietic stem cell proliferation
Investigator(s):	Leung AYH
Department:	Medicine
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

Refer to hard copy

List of Research Outputs

Au W.Y., Ma S.Y., Chim J.C.S., Choy C., Loong F., Lie A.K.W., Lam C.C.K., Leung A.Y.H., Tse E.W.C., Yau C.C., Liang R.H.S. and Kwong Y.L., Clinicopathologic features and treatment outcome of mature T-cell and natural killer-cell lymphomas diagnosed according to the World Health Organization classification scheme: a single center experience of 10 years, Annals of Oncology. 2005, 16(2): 206-214.

Au W.Y., Chim J.C.S., Lie A.K.W., Leung A.Y.H., Tse E.W.C., Ma S.Y., Liang R.H.S., Pang A.W.K., Kumana C.R. and Kwong Y.L., Treatment of relapsed acute promyelocytic leukemia by arsenic-based strategies without hematopoietic stem cell transplantation in Hong Kong: a seven-year experience, American Society of Haematology Annual Scientific Meeting. 2004.

Chim J.C.S., Loong F., Leung A.Y.H., Tsang J. and Ooi C.G.C., Primary follicular lymphoma of the small intestine, Leukaemia & Lymphoma. 2004, 45(7): 1463-6.

Hui C.K., Lie A., Au W.Y., Leung A.Y.H., Ma S.Y., Cheung W.W., Zhang H., Chim C.S., Kwong Y.L., Liang R.H.S. and Lau G., A long-term follow-up study on hepatitis B surface antigen-positive patients undergoing allogeneic hematopoietic stem cell transplantation, Blood. 2005, 106: 464-9.

Hui C.K., Lie A.K.W., Au W.Y., Ma S.Y., Leung A.Y.H., Zhang H., Sun J.Z., Cheung W.W.W., Chim J.C.S., Kwong Y.L., Liang R.H.S. and Lau G., Effectiveness of prophylactic Anti-HBV therapy in allogeneic hematopoietic stem cell transplantation with HBsAg positive donors, American Journal of Transplantation. 2005, 5(6): 1437-45.

Kwok J.S.Y., Leung A.Y.H., Lie A.K.W., Lee T.L., Lau Y.L., Chu P., Jones B.M., Hawkins B.R. and Liang R.H.S., Antirecipient helper and cytotoxic T-cell frequencies in bone marrow transplantation, Bone Marrow Transplantation. 2004, 34(3): 207-213.

Leung A.Y.H. and Verfaillie C.M., All-trans retinoic acid (ATRA) enhances maintenance of primitive human hematopoietic progenitors and skews them towards myeloid differentiation in a stroma-noncontact culture system, Experimental Hematology. 2005, 33(4): 422-427.

Leung A.Y.H. and Kwong Y.L., BK virus: a frequent cause of infection in transplant patients, Infection. 2005.

Leung A.Y.H., Mendenhall E.M., Kwan T.F., Liang R.H.S., Eckfeldt C., Chen E., Hammerschmidt M., Grindley S., Ekker S.C. and Verfaillie C.M., Characterization of expanded intermediate cell mass in zebrafish chordin morphant embryos, Developmental Biology. 2005, 277(1): 235-254.

Leung A.Y.H., Chan M.T.L., Yuen K.Y., Cheng V.C.C., Chan K.H., Wong L.P., Liang R.H.S., Lie A.K.W. and Kwong Y.L., Ciprofloxacin Decreased Polyoma BK Virus Load in Patients Who Underwent Allogeneic Hematopoietic Stem Cell Transplantation, Clinical Infectious Disease. 2005, 40: 528-537.

Leung A.Y.H., Chan M.T.L. and Kwong Y.L., Genotyping of the noncoding control region of BK virus in patients with haemorrhagic cystitis after allogeneic haematopoietic stem cell transplantation, Bone Marrow Transplantation. 2005, 35: 531?532.

Leung A.Y.H., Polyma BK virus and haemorrhagic cystitis in haematopoietic stem cell transplantation: a Changing paradigm, Roche Asian Transplantation and Immunology Frum, Jeju, Korea. 2005.

Leung A.Y.H., Chan M.T.L., Cheng V.C.C., Lie A.K.W., Yuen K.Y. and Kwong Y.L., Polyoma BK viruria in patients undergoing autologous hematopoietic stem cell transplantation, Bone Marrow Transplantation. 2005, 35: 1029?1030.

Leung A.Y.H., Chan M.T.L., Cheng V.C.C., Yuen K.Y. and Kwong Y.L., Quantification of Adenovirus in the Lower Respiratory Tract of Patients without Clinical Adenovirus-Related Respiratory Disease, Clinical Infectious Disease. 2005, 40: 1541-1544(online).

Leung A.Y.H. and Verfaillie C.M., Stem Cell Model of Hematopoiesis, In: Hoffman R ed Churchill livingstone, Hematology Basic Principles and Practice. 2005, 4th Edition: chaper 17.

Leung A.Y.H., The use of zebrafish as a model for the study of primitive hematopoiesis during embryonic development, Joint seminar of CDB and the University of Hong Kong, Kyoto, Japan. 2005.

Leung A.Y.H. and Liang R.H.S., Thrombocytopenia after gemtuzumab is reversible by intravenous immunoglobulin, Leukemia. 2005, 19(6): 1077-8.

Lie A.K.W., Au W.Y., Ma S.Y., Leung A.Y.H., Tse E.W.C., Chan G.C.F., Ha S.Y., Lau Y.L., Kwong Y.L. and Liang R.H.S., Haemopoietic stem cell transplantation in Hong Kong – 14 years of experience at Queen Mary Hospital, 10th Congress of the International Society of hematology, Asian Pacific Division, Nagoya, Japan. Nagoya, Japan, 2004.

Ma S.Y., Au W.Y., Lie A.K., Ng I.O.L., Leung A.Y.H., Tse E.W.C., Liang R.H.S., Lau G. and Kwong Y.L., Liver graft-versus-host disease after donor lymphocyte infusion for relapses of hematologic malignacies post allogeneic hematopoietic stem cell transplantation, Bone Marrow Transplant. 2004, 34: 57-61.

Researcher : Leung CM

List of Research Outputs

Mak J.C.W., Leung C.M., Ho S.P., Law K.W., Tsang K.W.T., Lam W.K., Ip M.S.M. and Chan M.M.W., Genetic susceptibility of transforming growth factor beta-1 common polymorphisms to Chinese patients with asthma, American Thoracic Society International Conference, San Diego, USA. May 2005. Proceedings of the American Thoracic Society. 2005, p.A78.

Mak J.C.W., Ho J.C.M., Ho S.P., Leung C.M., Law K.W., Ip M.S.M. and Chan M.M.W., Polymorphisms of superoxide dismutase and catalase genes and their functional activity levels in Chinese patients with asthma, American Thoracic Society International Conference, San Diego, USA. May 2005. Proceedings of the American Thoracic Society . 2005, p.A78.

Mak J.C.W., Leung C.M., Ho S.P., Lam W.K., Tsang K.W.T., Ip M.S.M. and Chan M.M.W., Systemic oxidative and antioxidative status in Chinese patients with asthma, Journal of Allergy and Clinical Immunology. 2004, 114(2): 260-264.

Researcher : Leung JCK

Project Title:	Serum markers for monitoring the onset and outcome of severe acute respiratory syndrome (SARS)-associated acute respiratory distress syndrome (ARDS)
Investigator(s):	Leung JCK, Tam S, Wu AYY, Lai KN
Department:	Medicine
Source(s) of Funding:	VCO SARS Research Fund
Start Date:	07/2003

Abstract:

To search for potential markers in the serum for predicting the onset and outcome of SARS-associated ARDS.

Project Title:	The roles of electrical charge of IgA1 in the pathogenesis of IgA nephropathy
Investigator(s):	Leung JCK, Lai KN
Department:	Medicine
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	09/2003

Abstract:

To characterize the glycosylation profile, size and possible components of IgA(1) molecules bearing different charges isolated from IgAN patients; to investigate the role of leucocytes and hepatocytes in the handling and metabolism of different charges of IgA(1) in IgAN; to explore the pathophysiologic effects of different charges of IgA(1) from IgAN patients on human mesangial cells.

Project Title:	The roles of electrical charge of IgA1 in the pathogenesis of IgA nephropathy
Investigator(s):	Leung JCK, Lai KN
Department:	Medicine
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2003

Abstract:

Project Title:	The role of transforming growth factor-[beta] and vascular endothelial growth factor in the pathogenesis of peritoneal membrane dysfunction
Investigator(s):	Leung JCK, Lai KN
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2004
Completion Date:	01/2005

Abstract:

To examine the pathophysiological effects of PDFs and their components on peritoneal cells; to understand the mechanism of TGF-[beta] and VEGF expression and their regulation inperitoneal cells.

Project Title:	Peritoneal membrane dysfunction in continuous ambulatory peritoneal dialysis (CAPD): the role of connective tissue growth factor (CTGF)
Investigator(s):	Leung JCK, Li FK, Lai KN
Department:	Medicine
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	01/2005

Abstract:

To examine the pathophysiological effects of PDFs and their components on peritoneal cells; to understand the mechanism of CTGF expression and its regulation in peritoneal cells; to explore the feasibility of treating peritoneal membrane dysfunction by blocking CTGF.

Project Title:	Peritoneal membrane dysfunction in continuous ambulatory peritoneal dialysis (CAPD): the role of connective tissue growth factor (CTGF)
Investigator(s):	Leung JCK
Department:	Medicine
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

Refer to hard copy

List of Research Outputs

Chan L.Y., Leung J.C.K., Tsang W.L., Tang S.C.W. and Lai K.N., Activation of tubular epithelial cells by mesangial-derived TNF-alpha: glomerulotubular communication in IgA nephropathy , Kidney International. 2005, 67: 602-612.

Chan L.Y., Leung J.C.K. and Lai K.N., Novel mechanisms of tubulointerstitial injury in IgA nephropathy: a new therapeutic paradigm in the prevention of progressive renal failure, Clinical and Experimental Nephrology . 2004, 8: 297-303.

Lai K.N., Leung J.C.K., Chan L.Y., Li F.K., Tang S.C.W., Lam M.F., Tse K.C., Yip T., Chan D.T.M., Wieslander A. and Vlassara H., Differential expression of receptors for advanced glycation end-products in peritoneal mesothelial cells exposed to glucose degradation products, Clinical and Experimental Immunology. 2004, 138: 466-475.

Lai K.N., Chan L.Y., Tsang W.L., Tang S.C.W. and Leung J.C.K., Differential regulation of AT1 and AT2 receptors by angiotensin II in human mesangial and renal proximal tubular epithelial cells, Journal of American Society of Nephrology. 2004, 15: 841A.

Lai K.N., Chan L.Y. and Leung J.C.K., Mechanisms of tubulointerstitial injury in IgA nephropathy, Kidney International. 2005, 67(suppl 94): S110-S115.

Lai K.N., Chan L.Y., Tang S.C.W., Tsang W.L., Li F.K., Lam M.F., Lui S.L. and Leung J.C.K., Mesangial expression of angiotensin II receptor in IgA nephropathy and its regulation by polymeric IgA1 , Kidney International. 2004, 66: 1403-1416.

Lai K.N., Tang S.C.W., Tsang W.L., Chan L.Y. and Leung J.C.K., Ganaderma extract prevents albumin-induced oxidative damage and chemokine synthesis in cultured human proximal tubular epithelial cells, Journal of American Society of Nephrology. 2004, 15: 107A.

Lam M.F., Yip P.S., Leung J.C.K., Chan D.T.M., Lo W.K. and Lai K.N., Mannose binding lectin gene mutation and incidence rate of peritonitis in long-term peritoneal dialysis patients, Journal of American Society of Nephrology. 2004, 15: 598A.

Leung J.C.K., Chan L.Y., Tsang W.L., Tang S.C.W. and Lai K.N., Anti-macrophage migration inhibitory factor reduces transforming growth factor-beta 1 expression in experimental IgA nephropathy, Nephrology Dialysis Transplantation. 2004, 19: 1976-1985.

Leung J.C.K., Chan L.Y., Tsang W.L., Guo H., Tang S.C.W., Chan D.T.M. and Lai K.N., Differential expression of aquaporins in the kidneys of streptozotocin-induced diabetic mice , Nephrology. 2005, 10: 63-72.

Leung J.C.K., Chan Y.Y., Li F.K., Tang S.C.W., Chan K.W., Chan D.T.M., Lam M.F., Wieslander A. and Lai K.N., Glucose degradation products downregulate ZO-1 expression in human peritoneal mesothelial cells: the role of VEGF, Nephrology Dialysis Transplantation. 2005, 20(7): 1336-1349.

Leung J.C.K., Chan L.Y., Tsang W.L., Tang S.C.W. and Lai K.N., Increased synthesis of TNF-a and IL-6 by mesangial cells cultured with polymeric anionic IgA from patients with IgA nephropathy, Journal of American Society of Nephrology. 2004, 15: 224A.

Li Y.J., Du Y., Li C.X., Guo H., Leung J.C.K., Lam M.F., Yang N., Huang F., Chen Y., Feng J.Q., Maxwell P.H., Lai K.N. and Wang Y., Family-based association study showing that immunoglobulin A nephropathy is associated with the polymorphisms 2093C and 2180T in the 3' untranslated region of the Megsin gene , Journal of American Society of Nephrology. 2004, 15: 1739-1747.

Tang S.C.W., Leung J.C.K., Chan L.Y., Tsang W.L. and Lai K.N., Albumin-induced interleukin-8 expression in renal tubular cells is abrogated by angiotensin type 2 but not type 1 receptor blockade, Journal of American Society of Nephrology. 2004, 15: 847A.

Researcher : Leung JKH

List of Research Outputs

Yung S.S.Y., Tsang R.C.W., Leung J.K.H. and Chan D.T.M., Anti-DNA antibodies from patients with lupus nephritis induce IL-6 expression in renal tubular epithelial cells, Nephrology. 2005, 10: A277.

Yung S.S.Y., Tsang R.C.W., Leung J.K.H. and Chan D.T.M., Induction of IL-6 by anti-DNA antibodies in proximal tubular epithelial cells varies with the activity of lupus nephritis, Lupus. 2005, 14: 237.

Yung S.S.Y., Tsang R.C.W., Leung J.K.H. and Chan D.T.M., Induction of IL-6 synthesis in proximal tubular epithelial cells by anti-DNA antibodies varies with lupus nephritis activity, 10th Medical Research Conference. 19-20 February 2005. Nephrology 45.

Zhang Q., Yung S.S.Y., Leung J.K.H. and Chan D.T.M., High Glucose Concentration Reduces Human Mesangial Cell alpha-actinin-1 and F-actin Expression through the induction of TGF-beta1 and PKC-alpha, Journal of the American Society of Nephrology. 2004, 15: 726A.

Zhang Q., Yung S.S.Y., Leung J.K.H. and Chan D.T.M., The effect of elevated glucose concentration on the expression of alpha-actinin-1 and F-actin in human mesangial cells, 10th Medical Research Conference. 19-20 February 2005. Nephrology 47.

Researcher : Leung KC

List of Research Outputs

Ho W.L., Chan Y.L., Leung K.C., Kung M.H.W., Ramsden D.B. and Ho S.L., Potential Role Of Uncoupling Proteins, Ucp2, -4, And -5, In The Neuroprotective Effects Of Estrogen On Mpp+-induced Neurotoxicity. , 8th International Congress of Parkinson's disease & Movement Disorders, Rome, Italy. 2004.

Researcher : Leung RCM

List of Research Outputs

Tsang K.W.T., Tipoe G.L., Mak J.C.W., Sun J.Z., Wong M.P., Leung R.C.M., Tan K.C.B., MedStat C.K.M., Ho J.C.M., Ho P.L., Rutman A. and Lam W.K., Ciliary central microtubular orientation is of no clinical significance in bronchiectasis, Respiratory Medicine. 2005, 99: 290-297.

Researcher : Leung TWT

List of Research Outputs

Tsang J.W., Leung A.W., Yau T.C., Liang R.H.S., Yeung D.W., Leung T.W.T., Teo P.M., Cheung P.S. and Epstein R., Multidisciplinary management of early-stage breast cancer in the Asia-Pacific region, Medical Progress. 2004, 31: 485-96.

Researcher : Leung YH

List of Research Outputs

Cheung B.M.Y., Leung Y.H., Man Y.B., Wong L.Y.F. and Lau C.P., Association of Blood Pressure and Obesity with a Single Nucleotide Polymorphism at 17p12, American Journal of Hypertension. 2005, 18(5) Suppl: A79.

Cheung B.M.Y., Leung Y.H., Man Y.B. and Lau C.P., Association of Essential Hypertension with the WNK4 Gene, the Molecular Switch Controlling Renal Sodium and Potassium Excretion, Cardiovasc Drugs Thera. 2004, 18 (Suppl) 1: 8.

Cheung B.M.Y., Man Y.B., Leung Y.H. and Wong L.Y.F., Association of Single Nucleotide Polymorphisms in the Urotensin II Gene with Plasma Insulin and Hypertension, American Journal of Hypertension. 2005, 18: 79A.

Cheung B.M.Y., Leung Y.H., Man Y.B. and Wong L.Y.F., Elevated Plasma Concentration of Urotensin II in Hypertension, 3rd Asian-Pacific Congress on Hypertension, Singapore 2004.

Cheung B.M.Y., Leung Y.H., Man Y.B. and Wong L.Y.F., Elevated Plasma Concentration of Urotensin II in Hypertension, J Hypertens. 2004, 22 (Suppl 2): S188.

Cheung B.M.Y., Hwang I.S.S., Li C., Tsang K.W.T., Leung Y.H., Kumana C.R. and Tang F., Increased Adrenomedullin Expression in Lungs in Endotoxaemia, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong. 2004.

Cheung B.M.Y., Leung Y.H., Man Y.B. and Wong L.Y.F., Plasma Concentration of Urotensin II is Raised in Hypertension, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong. 2004.

Cheung B.M.Y., Leung Y.H., Man Y.B. and Wong L.Y.F., Plasma Concentration of Urotensin II is Raised in Hypertension, J Hypertens. 2004, 22: 1341-4.

Kwok P.W., Leung Y.H., Sun J.Z., Yan C.P.K., Ooi C.G.C., Ho P.L., Ho J.C.M., Tipoe G.L., Lam W.K. and Tsang K.W.T., The Effects of Gelomyrtol Forte on Human Ciliary Beat Frequency in vitro, Abstract Book of the 10th Medical Research Conference, University Department of Medicine, The University of Hong Kong, 19-20 February. 2005, page 65.

Kwok R., Leung Y.H., Sun J.Z., Yan C.P.K., Ooi C.G.C., Ho P.L., Ho J.C.M., Tipoe G.L., Lam W.K. and Tsang K.W.T., The effects of gelomyrtol forte on human ciliary beat frequency in vitro, Respirology. 2004, 9 (Suppl): A162 (290).

Mak J.C.W., Ho S.P., Leung Y.H., Ho P.L., Ooi C.G.C., Yan C.P.K., Ko K.W., Ip M.S.M., Lam W.K. and Tsang K.W.T., Elevated levels of transforming growth factor- beta 1 in serum of patients with stable bronchiectasis, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A134.

Tsang K.W.T., Tipoe G.L., Sun J.Z., Tan K.C.B., Leung Y.H., Yan C.P.K., Ko K.W., Ooi C.G.C., Ho J.C.M. and Lam W.K., Clinical value of ciliary assessment in bronchiectasis, Lung. 2005, 183(2): 73-86.

Tsang K.W.T., Tan K.C.B., Ho P.L., Ooi C.G.C., Khong P.L., Leung Y.H., Mak J.C.W., Tipoe G.L., Ko K.W. and Lam W.K., Exhaled nitric oxide in bronchiectasis: the effects of inhaled corticosteroid therapy, International Journal of Tuberculosis and Lung Disease. 2004, 8(11): 1301-1307.

Wong L.Y.F., Man Y.B., Leung Y.H. and Cheung B.M.Y., Interleukin-6 Gene -573G>C Promoter Polymorphism is Associated with Plasma Fibrinogen Level and Hypertension in Hong Kong Chinese, American Journal of Hypertension. 2005, 18: 186A.

Researcher : Li FK

List of Research Outputs

Chan D.T.M., Tse K.C., Tang C.S.O., Lai K.N. and Li F.K., Long-term outcome of patients with diffuse proliferative lupus nephritis treated with prednisolone and oral cyclophosphamide followed by azathioprine. , Lupus. 2005, 14(4): 265-272.

Chan D.T.M., Tse K.C., Tang C.S.O., Mok T.M.Y., Li F.K. and Hong Kong Nephrology Study G.R.O.U.P., Long-term study of mycophenolate mofetil as continuous induction and maintenance treatment for diffuse proliferative lupus nephritis, Journal of American Society of Nephrology. 2005, 16(4): 1076-1084.

Chok K.S.H., Lam C.M., Li F.K., Ng K.K.C., Poon R.T.P., Lo C.M. and Fan S.T., Management of hepatocellular carcinoma in renal transplant recipients, Journal of Surgical Oncology. 2004, 87(3): 139-142.

Lai K.N., Leung J.C.K., Chan L.Y., Li F.K., Tang S.C.W., Lam M.F., Tse K.C., Yip T., Chan D.T.M., Wieslander A. and Vlassara H., Differential expression of receptors for advanced glycation end-products in peritoneal mesothelial cells exposed to glucose degradation products, Clinical and Experimental Immunology. 2004, 138: 466-475.

Lai K.N., Chan L.Y., Tang S.C.W., Tsang W.L., Li F.K., Lam M.F., Lui S.L. and Leung J.C.K., Mesangial expression of angiotensin II receptor in IgA nephropathy and its regulation by polymeric IgA1 , Kidney International. 2004, 66: 1403-1416.

Lam M.F., Lo W.K., Chu F.S., Li F.K., Yip T.P., Tse K.C., Chan D.T.M. and Lai K.N., Retroperitoneal leakage as a cause of ultrafiltration failure, Peritoneal Dialysis International. 2004, 24(5): 466-470.

Lam M.F., Yip T.P.S., Tse K.C., Li F.K., Lui S.L., Lai K.N. and Chan D.T.M., Sirolimus in kidney transplantation: a pilot study in Chinese patients, Hong Kong Journal of Nephrology. Hong Kong, 2004, 6(1): 38-42.

Leung J.C.K., Chan Y.Y., Li F.K., Tang S.C.W., Chan K.W., Chan D.T.M., Lam M.F., Wieslander A. and Lai K.N., Glucose degradation products downregulate ZO-1 expression in human peritoneal mesothelial cells: the role of VEGF, Nephrology Dialysis Transplantation. 2005, 20(7): 1336-1349.

Li F.K., Lam M.F., Yip P.S., Chan D.T.M. and Lai K.N., Refractory fluid overload in CAPD patients: management strategies and outcomes, Journal of American Society of Nephrology. 2004, 15: 637A.

Lo W.K., Lui S.L., Chan D.T.M., Li F.K., Lam M.F., Tse K.C., Tang C.S.O., Choy C.B.Y. and Lai K.N., Minimal and optimal peritoneal Kt/V targets: results of an anuric peritoneal dialysis patient's survival analysis. , Kidney International. 2005, 67(5): 2032-2038.

Lui S.L., Yip P.S., Tse K.C., Lam M.F., Li F.K., Lai K.N. and Lo W.K., Simultaneous removal and reinsertion of peritoneal dialysis catheters for the treatment of refractory pseudomonas exit site infection in CAPD patients, Nephrology. 2005, 10(suppl): A68.

Lui S.L., Tang S., Li F.K., Choy C.B.Y., Chan D.T.M., Lo W.K. and Lai K.N., Tuberculous infection in southern Chinese renal transplant recipients, Clinical transplantation. 2004, 18(6): 666-671.

Researcher : Li G

List of Research Outputs

Chan C.C., Li G., Ehman R.L., Grimm R.C., Cao G., Li R. and Yang E.S., Localized Application of Shear Wves to Tissue for MR Elastography via a Needle Device, 12th ISMRM. 2005, 2010.

Chan C.C., Li G., Ehman R.L., Grimm R.C., Cao G., Li R. and Yang E.S., Shear Waves Induced By Needle or Touch: An MRE Study, Conference on Biomedical Engineering, BME 2004. 147-151.

Chan H.D., Li G. and Tan L.H., An fMRI study of neural circuitry of nouns and verbs in early bilinguals’ brain, Annual Meeting of the Cognitive Neuroscience Society. 2005.

Li G., Zou L., Jack C...R... and Yang E.S., Coenzyme Q10 Inhibited The Opening of the Mitochondrial Permeability Transition Pore to Protect SHSY5Y Neuronal Cells, The Alzheimer's Association International Conference on Prevention of Dementia. 2005, 143.

Li G., Zou L., Cao C., Jack C.R. and Yang E.S., Coenzyme Q10 Protects SHSY5Y Neuronal Cells by the Inhibition of the Opening of the Mitochondrial Permeability Transition Pore, Fourth World Conference of the International CoenzymeQ10 Association. 2005, 134-136.

Li G., Zou L., Cao C. and Yang E.S., Coenzyme Q10 Protects SHSY5Y Neuronal Cells form Toxicity of Beta Amyloid-42 via Inhibition of Mitochondrial Permeability Transition Pore Opening, Drug Discovery in Neurodegenerative Diseases. 2004, 34.

Li G., Xia H.H.X., Chen M.H., Chan O.O., Cho C.H., Lam S.K., Berg D., Feng Z., Langenbach R. and Wong B.C.Y., Effects of Cyclooxygenase-1 and -2 Gene Disruption on Helicobacter pylori-Induced Inflammation, Apoptosis and Proliferation, Journal of Gastroenterology and Hepatology. 2004, 19(Suppl.): A299.

Li G., Zou L., Jack C...R... and Yang E.S., MRI Study the Neuroprotection of Melatonin in the COX-1 Gene Wild-Type Mice, 12th ISMRM. 2005, 999.

Li G., Wong K.K.K., Ng M.C., Luk K.D.K., Yang E.S. and Hu Y., Proton Density Change in Spinal Cord fMRI Induced by Acupoint Stimulation, 12th ISMRM. 2005, 1095.

Li G., Chan C.C., Ehman R.L., Rossman P.J., Cao G. and Yang E.S., Shear Waves Imaging Induced by Moving Needle, The Fifth National MRI Academic Congress. 2004, 157-159.

Li G., Zou L., Jack C...R... and Yang E.S., The effects of Coenzyme Q10 in Transgenic Mouse Models of Alzheimer's Disease and Cerebral Ischemia: Volume MRI Study, 12th ISMRM. 2005, 998.

Li G., Zou L., Jack C...R... and Yang E.S., Volume MRI Study: The Effects of Coenzyme Q10 in APP/PS1 Mouse Models of Alzheimer's Disease and Cerebral Ischemia, The Alzheimer's Association International Conference on Prevention of Dementia. 2005, 36.

Li G., Zou L., Jack C.R. and Yang E.S., Volume MRI Study: The Effects of Coenzyme Q10 in Transgenic Mouse Models of Alzheimer's Disease and Cerebral Ischemia, Fourth World Conference of the International CoenzymeQ10 Association. 2005, 38-40.

Tang M.Y., Li G., Chan C.C., Wong K.K.K., Li R. and Yang E.S., Brain Activation at Temporal Lobe Induced by Foot Reflexology: an fMRI Study, 11th Annual NeuroImage Meeting. 2005, 1445.

Tang M.Y., Li G., Chan C.C., Wong K.K.K., Li R. and Yang E.S., Vision Related Reflex Zone at the Fect: An fMRI Study, 11th Annual NeuroImage Meeting. 2005, 1431.

Wong K.K.K., Ng M.C., Li G., Hu Y., Luk K.D.K. and Yang E.S., Proton Density-weighted Spinal fMRI Comparison between Sensorimotor Task and Acupoint Stimulation, 12th ISMRM. 2005, 1465.

Xia H.H.X., Li G., Chen M.H., Chan O.O., Cho C.H., Lam S.K., Berg D., Feng Z., Langenbach R. and Wong B.C.Y., Cyclooxygenase-1 and -2 Gene Disruption Potentiate TH1 Polarization in Response to Helicobacter pylori, Journal of Gastroenterology and Hepatology. 2004, 19(Suppl.): A366.

Zhao X.I.A., Li N.I.N.G., Li G., Glahn D.A.V.I.D. and Gao J.I.A. .H.O.N.G., Detection of the Unknown Onset Time of Plateau Brain Activation in fMRI by Derivative Temporal Clustering Analysis, 11th Annual NeuroImage Meeting. 2005, 592.

Researcher : Li G

List of Research Outputs

Chan C.C., Li G., Ehman R.L., Grimm R.C., Cao G., Li R. and Yang E.S., Localized Application of Shear Wves to Tissue for MR Elastography via a Needle Device, 12th ISMRM. 2005, 2010.

Chan C.C., Li G., Ehman R.L., Grimm R.C., Cao G., Li R. and Yang E.S., Shear Waves Induced By Needle or Touch: An MRE Study, Conference on Biomedical Engineering, BME 2004. 147-151.

Chan H.D., Li G. and Tan L.H., An fMRI study of neural circuitry of nouns and verbs in early bilinguals’ brain, Annual Meeting of the Cognitive Neuroscience Society. 2005.

Li G., Zou L., Jack C...R... and Yang E.S., MRI Study the Neuroprotection of Melatonin in the COX-1 Gene Wild-Type Mice, 12th ISMRM. 2005, 999.

Li G., Wong K.K.K., Ng M.C., Luk K.D.K., Yang E.S. and Hu Y., Proton Density Change in Spinal Cord fMRI Induced by Acupoint Stimulation, 12th ISMRM. 2005, 1095.

Li G., Chan C.C., Ehman R.L., Rossman P.J., Cao G. and Yang E.S., Shear Waves Imaging Induced by Moving Needle, The Fifth National MRI Academic Congress. 2004, 157-159.

Li G., Zou L., Jack C...R... and Yang E.S., The effects of Coenzyme Q10 in Transgenic Mouse Models of Alzheimer's Disease and Cerebral Ischemia: Volume MRI Study, 12th ISMRM. 2005, 998.

Tang M.Y., Li G., Chan C.C., Wong K.K.K., Li R. and Yang E.S., Brain Activation at Temporal Lobe Induced by Foot Reflexology: an fMRI Study, 11th Annual NeuroImage Meeting. 2005, 1445.

Tang M.Y., Li G., Chan C.C., Wong K.K.K., Li R. and Yang E.S., Vision Related Reflex Zone at the Fect: An fMRI Study, 11th Annual NeuroImage Meeting. 2005, 1431.

Wong K.K.K., Ng M.C., Li G., Hu Y., Luk K.D.K. and Yang E.S., Proton Density-weighted Spinal fMRI Comparison between Sensorimotor Task and Acupoint Stimulation, 12th ISMRM. 2005, 1465.

Researcher : Li GR

Project Title:	Volume-sensitive chloride current and cell volume regulation in human atrial myocytes
Investigator(s):	Li GR, Lau CP, Chiu SW, Tse HF
Department:	Medicine
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	12/2001

Abstract:

To determine the intracellular signaling pathways that regulate I_Cl.vol and cell volume in human atrium; to determine whether I_Cl.vol is persistently activated in atrial myocytes from patients with dilated atrial cardiomyopathy.

Project Title:	Effects of calcium channel blockers on repolarization potassium currents in human atrial cells
Investigator(s):	Li GR, Chiu S.W.
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Abstract:

To evaluate the effects of diltiazem and verapamil on I[to1] and I[Kur] in human atrial cells.

Project Title:	Ionic channels of mesenchymal stem cells from bone marrow and cell proliferation
Investigator(s):	Li GR, Lau CP, Chung SSM, Tse HF
Department:	Medicine
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	12/2003

Abstract:

To analyze the molecular identities of IK_DR, I_KCa, and I_Na in MSCs from rat bone marrow with semi-quantitative reverse transcript-polymeterase chain reaction (RT-PCR) and patch clamp techniques; to test the hypothesis that the three types of channels (IK_DR, I_KCa and I_Na) are involved in the proliferation of rat MSCs by determining cell proliferation in the absence and presence of channel blockers and modulators.

Project Title:	Effects of the compound a from the TCM Xuelianhua on Ionic channel currents in cardiac myocytes
Investigator(s):	Li GR, Lau CP
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	12/2003
Completion Date:	11/2004

Abstract:

To study : (1) the effects of the compound A on inward sodium current INa and calcium current (ICa); (2) effects of the compound A on outward repolarization currents, i.e. inwardly-rectifying potassium current (IK1), rapid and slow delayed rectifier potassium currents (IKr and IKs) in guinea pig and goad ventricular myocytes.

Project Title:	Ionic channels of mesenchymal stem cells from bone marrow and cell proliferation
Investigator(s):	Li GR, Lau CP, Chung SSM, Tse HF
Department:	Medicine
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	12/2003

Abstract:

Project Title:	Potassium channel gene transfer in cardiomypathic failing heart - a possible gene therapy strategy for electrophysiological remodeling
Investigator(s):	Li GR
Department:	Medical Faculty
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2004

Abstract:

Refer to hard copy

Project Title:	Modulation of cloned human cardiac potassium channel by protein tyrosine kinase
Investigator(s):	Li GR
Department:	Medical Faculty
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Abstract:

To clarify specific PTK pathway that is involved in the modulation of I_Ks channels.

List of Research Outputs

Wu K.K., Shin V.Y., Lam K.Y., Wong P.S.H., Tai K.K., So H.L., Li G.R. and Cho C.H., Calcium channels antagonists inhibited fast inward sodium current and cell motility in rat gastric mucosal cells, Symposium on Gastrointestinal Disorders: Molecular Mechanisms of Pathogenesis. Seoul Korea, 2005, 28.

Researcher : Li LSW

List of Research Outputs

Lee T.M.C., Chan C.C.H., Ho S.L. and Li L.S.W., Prose memory in patients with idiopathic Parkinson’s disease. , Parkinsonism and Related Disorders . 2005, 11: 453-458.

Luk H.H., Pang J., Li L.S.W. and Ng M.M.T., Use of Antiplatelet Drugs in the Stroke Unit of a Hong Kong Hospital, Pharmacy World & Science . 2005, 27(3): 258-262.

Sit J.W., Wong T.K., Clinton M., Li L.S.W. and Fong Y.M., Stroke care in the home: the impact of social support on the general health of family caregivers, Journal of Clinical Nursing. 2004, 13(7): 816-24.

Yan T., Hui-Chan C.W. and Li L.S.W., Functional electrical stimulation improves motor recovery of the lower extremity and walking ability of subjects with first acute stroke: a randomized placebo-controlled trial, Stroke. 2005, 36(5): 80-5.

Yip J.T.H., Lee T.M.C., Leung K.K. and Li L.S.W., The role of subcortical brain structures in emotion recognition [Abstract]., XXVIII International Congress of Psychology.. Beijing, China, 2004.

Yu C.M., Lau C.P., Chau J., McGhee S.M., Kong S.L., Cheung B.M.Y. and Li L.S.W., A short course of cardiac rehabilitation program is highly cost effective in improving long-term quality of life in patients with recent myocardial infarction or percutaneous coronary intervention, Archives of Physical Medicine and Rehabilitation. 2004, 85(12): 1915-22.

Researcher : Liang RHS

Project Title:	Quantification of circulating Epstein Barr viral DNA in patients with malignant lymphoma: diagnostic and prognostic significance
Investigator(s):	Liang RHS, Kwong YL, Au WY
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002

Abstract:

To define if circulating Epstein-Barr viral (EBV) DNA can be correlated with tumor load in patients with malignant lymphoma; to define the biologic significance and propgnostic value of circulating EBV DNA in malignant lymphoma.

Project Title:	Molecular determinants of arsenic resistance in APL and prognostic factors of APL in the post arsenic era
Investigator(s):	Liang RHS, Kwong YL, Au WY
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Abstract:

To define the relative significance of FLT-3 mutation and aberrant p15 methylation in prognostication of acute promyelocytic leukaemia (APL) in the era of arsenic salvage; to define the molecular role of molecular transport proteins, protein kinase and tumor suppressor genes in arsenic resistant APL.

Project Title:	Adoptive transfer of herpes zoster cellular immunity to BMT patients by vaccination of seropositive donors with live-attenuated varicella zoster vaccine
Investigator(s):	Liang RHS, Leung AYH
Department:	Medicine
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	12/2003

Abstract:

To study whether the use of live-attenuated VZV vaccine in VZV-seropositive donors prior to BMT achieves three objectives: boosts the cellular and humoral immunity of the donors, transfers immunity to patients post BMT, and protects BMT patients from the development of HZ after transplantation.

Project Title:	Adoptive transfer of herpes zoster cellular immunity to BMT patients by vaccination of seropositive donors with live-attenuated varicella zoster vaccine
Investigator(s):	Liang RHS, Leung AYH
Department:	Medicine
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	12/2003

Abstract:

List of Research Outputs

Ambekar C.S., Lee J.S.K., Cheung B.M.Y., Chan L.C., Liang R.H.S. and Kumana C.R., Metabolism of Chloramphenicol Succinate, a Competitive Substrate and Inhibitor of Succinate Dehydrogenase: Possible Reason for its Toxicity, Toxicology in Vitro. 2004, 18: 441-7.

Au W.Y., Lie A.K.W., Kung A.W.C., Liang R.H.S., Hawkins B.R. and Kwong Y.L., Autoimmune thyroid dysfunction after hematopoietic stem cell transplantation, Bone Marrow Transplantation. 2005, 35(4): 383-8.

Au W.Y., Ma S.Y., Chim J.C.S., Choy C., Loong F., Lie A.K.W., Lam C.C.K., Leung A.Y.H., Tse E.W.C., Yau C.C., Liang R.H.S. and Kwong Y.L., Clinicopathologic features and treatment outcome of mature T-cell and natural killer-cell lymphomas diagnosed according to the World Health Organization classification scheme: a single center experience of 10 years, Annals of Oncology. 2005, 16(2): 206-214.

Au W.Y., Gascoyne R.D., Klasa R.D., Connors J.M., Gallagher R.P., Le N.D., Loong F., Law C.K. and Liang R.H.S., Incidence and spectrum of non-Hodgkin lymphoma in Chinese migrants to British Columbia, British Journal of Haematology. 2005, 128: 792-196.

Au W.Y., Chan C., Pang A., Lie A.K.W., Liang R.H.S., Yuen P.W., Shek T.W.H., Kwong Y.L. and Pang A.W.K., Nonhematologic malignancies after allogeneic hematopoietic stem cell transplantation: incidence and molecular monitoring, Bone Marrow Transplantation. 2004, 34: 981-985.

Au W.Y., Lie A.K.W., Liang R.H.S., Yuen P.W., Shek T.W.H. and Kwong Y.L., Secondary non-hematologic malignancies after allogeneic stem cell transplantation : incidence and molecular monitoring, 10th Congress of the International Society of hematology, Asian Pacific Division, Nagoya, Japan. Nagoya, Japan, 2004, 110.

Au W.Y., Chim J.C.S., Lie A.K.W., Leung A.Y.H., Tse E.W.C., Ma S.Y., Liang R.H.S., Pang A.W.K., Kumana C.R. and Kwong Y.L., Treatment of relapsed acute promyelocytic leukemia by arsenic-based strategies without hematopoietic stem cell transplantation in Hong Kong: a seven-year experience, American Society of Haematology Annual Scientific Meeting. 2004.

Chim J.C.S., Ho J.W.C., Ooi C.G.C., Choy C. and Liang R.H.S., Primary anaplastic large cell lymphoma of the pancreas, Leukaemia & Lymphoma. 2005, 46(3): 457-9.

Ha S.Y., Chan G.C.F., Lee T.L., Liang R.H.S., Lee C.W. and Lau Y.L., Treatment Outcome in Transfusion Dependent Thalassaemia Patients Who Underwent Sibling Cord Blood or Bone Marrow Transplantation Using a Standardised Conditioning Regimen, Ruby Jubilee Scientific Meeting, HK, 24-26 Sepember 2004 (Abstract in Hong Kong Journal of Paediatrics (new series). Hong Kong, Medcom Limited, 2004, 9 (suppl): 40.

Ha S.Y., Chan G.C.F., Lee T.L., Lee A.C.W., Liang R.H.S. and Lau Y.L., Treatment Outcome in Transfusion Dependent Thalassaemia Patients Who Underwent Sibling Cord Blood or Bone Marrow Transplantation using a Standardised Conditioning Regimen, 5th Guangdong - Hong Kong Paediatric Exchange Meeting, HK, 24 July 2004 . 2004.

Hon C., Au W.Y. and Liang R.H.S., Conjunctival carcinoma as a novel post-stem cell transplantation malignancy, Bone Marrow Transplantation. 2004, 34(2): 181-182.

Hui C.K., Lie A., Au W.Y., Leung A.Y.H., Ma S.Y., Cheung W.W., Zhang H., Chim C.S., Kwong Y.L., Liang R.H.S. and Lau G., A long-term follow-up study on hepatitis B surface antigen-positive patients undergoing allogeneic hematopoietic stem cell transplantation, Blood. 2005, 106: 464-9.

Hui C.K., Bowden S., Jackson K., Au W.Y., Fong D.Y.T., Lie A.K.W., Chim J.C.S., Liang R.H.S. and Lau G., Clinical significance of intrahepatic hepatitis B virus covalently closed circular DNA in chronic hepatitis B patients who received cytotoxic chemotheraphy, Blood. 2005, 105(6): 2616-2617.

Hui C.K., Lie A.K.W., Au W.Y., Ma S.Y., Leung A.Y.H., Zhang H., Sun J.Z., Cheung W.W.W., Chim J.C.S., Kwong Y.L., Liang R.H.S. and Lau G., Effectiveness of prophylactic Anti-HBV therapy in allogeneic hematopoietic stem cell transplantation with HBsAg positive donors, American Journal of Transplantation. 2005, 5(6): 1437-45.

Hui C.K., Sun J., Au W.Y., Lie A.K.W., Yueng Y.H., Zhang H., Lee N.P., Hou J., Liang R.H.S. and Lau G., Occult hepatitis B virus infection in hematopoietic stem cell donors in a hepatitis B virus endemic area, Journal of Hepatology. 2005, 42(6): 813-9.

Hui C.K., Yu J., Au W.Y., Zhang H., Bartholomeusz A., Locarnini S., Kwong Y.L., Liang R.H.S. and Lau G., Sexual transmission of hepatitis B infection despite the presence of hepatitis B virus immunity in recipients of allogeneic bone marrow transplantation, J Clin Virol. 2005, 32: 173-8.

Kwok J.S.Y., Leung A.Y.H., Lie A.K.W., Lee T.L., Lau Y.L., Chu P., Jones B.M., Hawkins B.R. and Liang R.H.S., Antirecipient helper and cytotoxic T-cell frequencies in bone marrow transplantation, Bone Marrow Transplantation. 2004, 34(3): 207-213.

Kwong Y.L. and Liang R.H.S., Treatment of natural killer cell malignancies, The Lymphoid Malignancies, Editor Lan Magrath, Third Edition. 2005.

Leung A.Y.H., Mendenhall E.M., Kwan T.F., Liang R.H.S., Eckfeldt C., Chen E., Hammerschmidt M., Grindley S., Ekker S.C. and Verfaillie C.M., Characterization of expanded intermediate cell mass in zebrafish chordin morphant embryos, Developmental Biology. 2005, 277(1): 235-254.

Leung A.Y.H., Chan M.T.L., Yuen K.Y., Cheng V.C.C., Chan K.H., Wong L.P., Liang R.H.S., Lie A.K.W. and Kwong Y.L., Ciprofloxacin Decreased Polyoma BK Virus Load in Patients Who Underwent Allogeneic Hematopoietic Stem Cell Transplantation, Clinical Infectious Disease. 2005, 40: 528-537.

Leung A.Y.H. and Liang R.H.S., Thrombocytopenia after gemtuzumab is reversible by intravenous immunoglobulin, Leukemia. 2005, 19(6): 1077-8.

Liang R.H.S., Associate Editor, Hematological Oncology. 2004.

Liang R.H.S., Editorial Board, Clinical Lymphoma. 2004.

Liang R.H.S., Editorial Board, Medical Progress. 2004.

Liang R.H.S., Guest Editor, Asian Pacific Cancer Review. 2004.

Liang R.H.S., Haematopoietic Stem Cell Transplantation for Blood Cancers , 9th Hong Kong Medical Forum. 2004.

Liang R.H.S., Management Of Chronic Hepatitis B Carriers With Hematological Malignancies, Visiting Professorship, Department Of Oncology, Unviversity Of California, Los Angeles. Los Angeles, USA, 2004.

Liang R.H.S., Nasal Lymphoma, Annual Meeting Of The Southern California Lymphoma Group. Los Angeles, USA, 2004.

Liang R.H.S., Planning For Healthcare Professionals, Hong Kong Hospital Authority Convention. Hong Kong, 2005.

Liang R.H.S., Supervisor Of Best Thesis Award, Hong Kong College Of Physicians. 2004.

Liang R.H.S., T-cell Lymphoma, 9th Interantional Conference On Malignant Lymphoma. Lugano, Switzerland, 2005.

Lie A.K.W., Au W.Y., Ma S.Y., Leung A.Y.H., Tse E.W.C., Chan G.C.F., Ha S.Y., Lau Y.L., Kwong Y.L. and Liang R.H.S., Haemopoietic stem cell transplantation in Hong Kong – 14 years of experience at Queen Mary Hospital, 10th Congress of the International Society of hematology, Asian Pacific Division, Nagoya, Japan. Nagoya, Japan, 2004.

Ma S.Y., Au W.Y., Lie A.K., Ng I.O.L., Leung A.Y.H., Tse E.W.C., Liang R.H.S., Lau G. and Kwong Y.L., Liver graft-versus-host disease after donor lymphocyte infusion for relapses of hematologic malignacies post allogeneic hematopoietic stem cell transplantation, Bone Marrow Transplant. 2004, 34: 57-61.

Srivastava G., Shen L., Au W.Y., Kwong Y.L. and Liang R.H.S., Molecular pathogenesis of nasal NK/T-cell lymphoma, Abstract of the Proc of 63rd Annual Meeting of the Japanese Cancer Association, 29 September - 1 October 2004, Fukuoka, Japan. 2004.

Tsang J.W., Leung A.W., Yau T.C., Liang R.H.S., Yeung D.W., Leung T.W.T., Teo P.M., Cheung P.S. and Epstein R., Multidisciplinary management of early-stage breast cancer in the Asia-Pacific region, Medical Progress. 2004, 31: 485-96.

Tse E.W.C. and Liang R.H.S., Natural killer cell neoplasms, Clinical lymphoma. 2004, 5(3): 197-201.

Researcher : Lie AKW

List of Research Outputs

Au W.Y., Lie A.K.W., Kung A.W.C., Liang R.H.S., Hawkins B.R. and Kwong Y.L., Autoimmune thyroid dysfunction after hematopoietic stem cell transplantation, Bone Marrow Transplantation. 2005, 35(4): 383-8.

Au W.Y., Ma S.Y., Chim J.C.S., Choy C., Loong F., Lie A.K.W., Lam C.C.K., Leung A.Y.H., Tse E.W.C., Yau C.C., Liang R.H.S. and Kwong Y.L., Clinicopathologic features and treatment outcome of mature T-cell and natural killer-cell lymphomas diagnosed according to the World Health Organization classification scheme: a single center experience of 10 years, Annals of Oncology. 2005, 16(2): 206-214.

Au W.Y., Lie A.K.W. and Cheng V.C.C., Hematopoietic progenitor cell transplantation from a donor with indeterminate human immunodeficiency virus antibody status, Transfusion. 2005, 45(5): 819-820.

Au W.Y., Chan C., Pang A., Lie A.K.W., Liang R.H.S., Yuen P.W., Shek T.W.H., Kwong Y.L. and Pang A.W.K., Nonhematologic malignancies after allogeneic hematopoietic stem cell transplantation: incidence and molecular monitoring, Bone Marrow Transplantation. 2004, 34: 981-985.

Au W.Y., Lie A.K.W., Liang R.H.S., Yuen P.W., Shek T.W.H. and Kwong Y.L., Secondary non-hematologic malignancies after allogeneic stem cell transplantation : incidence and molecular monitoring, 10th Congress of the International Society of hematology, Asian Pacific Division, Nagoya, Japan. Nagoya, Japan, 2004, 110.

Au W.Y., Lie A.K.W., Kung A.W.C., Mak W. and Kwong Y.L., Thyrotoxic periodic paralysis after allogeneic haematopoietic stem cell transplantation, British Journal of Haematology. 2005, 129(1): 160.

Au W.Y., Chim J.C.S., Lie A.K.W., Leung A.Y.H., Tse E.W.C., Ma S.Y., Liang R.H.S., Pang A.W.K., Kumana C.R. and Kwong Y.L., Treatment of relapsed acute promyelocytic leukemia by arsenic-based strategies without hematopoietic stem cell transplantation in Hong Kong: a seven-year experience, American Society of Haematology Annual Scientific Meeting. 2004.

Au W.Y., Lie A.K.W. and Cheng V.C.C., VDRL screening and haemopoietic stem cell transplantation, Bone Marrow Transplantation. 2005, 35: 1027-1028.

Chim J.C.S., Ooi C.G.C., Loong F., Au W.Y., Au W.Y. and Lie A.K.W., Side effects and good effects from new chemotherapeutic agents. Bortezomib in primary refractory plasmacytoma, Journal of Clinical Oncology. 2005, 23(10): 2426-8.

Hui C.K., Bowden S., Jackson K., Au W.Y., Fong D.Y.T., Lie A.K.W., Chim J.C.S., Liang R.H.S. and Lau G., Clinical significance of intrahepatic hepatitis B virus covalently closed circular DNA in chronic hepatitis B patients who received cytotoxic chemotheraphy, Blood. 2005, 105(6): 2616-2617.

Hui C.K., Lie A.K.W., Au W.Y., Ma S.Y., Leung A.Y.H., Zhang H., Sun J.Z., Cheung W.W.W., Chim J.C.S., Kwong Y.L., Liang R.H.S. and Lau G., Effectiveness of prophylactic Anti-HBV therapy in allogeneic hematopoietic stem cell transplantation with HBsAg positive donors, American Journal of Transplantation. 2005, 5(6): 1437-45.

Hui C.K., Sun J., Au W.Y., Lie A.K.W., Yueng Y.H., Zhang H., Lee N.P., Hou J., Liang R.H.S. and Lau G., Occult hepatitis B virus infection in hematopoietic stem cell donors in a hepatitis B virus endemic area, Journal of Hepatology. 2005, 42(6): 813-9.

Kwok J.S.Y., Leung A.Y.H., Lie A.K.W., Lee T.L., Lau Y.L., Chu P., Jones B.M., Hawkins B.R. and Liang R.H.S., Antirecipient helper and cytotoxic T-cell frequencies in bone marrow transplantation, Bone Marrow Transplantation. 2004, 34(3): 207-213.

Leung A.Y.H., Chan M.T.L., Yuen K.Y., Cheng V.C.C., Chan K.H., Wong L.P., Liang R.H.S., Lie A.K.W. and Kwong Y.L., Ciprofloxacin Decreased Polyoma BK Virus Load in Patients Who Underwent Allogeneic Hematopoietic Stem Cell Transplantation, Clinical Infectious Disease. 2005, 40: 528-537.

Leung A.Y.H., Chan M.T.L., Cheng V.C.C., Lie A.K.W., Yuen K.Y. and Kwong Y.L., Polyoma BK viruria in patients undergoing autologous hematopoietic stem cell transplantation, Bone Marrow Transplantation. 2005, 35: 1029?1030.

Lie A.K.W., Au W.Y., Ma S.Y., Leung A.Y.H., Tse E.W.C., Chan G.C.F., Ha S.Y., Lau Y.L., Kwong Y.L. and Liang R.H.S., Haemopoietic stem cell transplantation in Hong Kong – 14 years of experience at Queen Mary Hospital, 10th Congress of the International Society of hematology, Asian Pacific Division, Nagoya, Japan. Nagoya, Japan, 2004.

Szeto C.H., Shek T.W.H., Lie A.K.W., Au W.Y., Yuen P.W. and Kwong Y.L., Squamous cell carcinoma of the tongue complicating chronic oral mucosal graft-versus-host disease after allogeneic hematopoietic stem cell transplantation, American Journal of Hematology. 2004, 77(2): 200-202.

Researcher : Lin MC

Project Title:	Ethanol regulated gene transcription: identification of "ethanol-responsive-cis-element" in the promoter region of human MTP gene
Investigator(s):	Lin MC, Jin D
Department:	Institute of Molecular Biology
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2000

Abstract:

To identify and characterize the location, consensus sequences, and functional significance of the ERE in the promoter region of the human MTP gene; to isolate and characterize the transcription factor(s) that bind to this ERE; to identify other candidate genes that are regulated bia this ERE by computer-aided analysis; to validate the functional significance of this ERE by testing the effects of low concentrations of ethanol on the promoter activities of the candidate genes in vitro in humna cell lines; to determine the effect of a long term low/moderate ethanol consumption on gene expression profiles in vivo in rats; to determine the effect of ethanol consumption on gene expression profiles in Xenopus (African frogs) embryo.

Project Title:	Basic research on systemic damage in early stage and wound-healing after severe trauma
Investigator(s):	Lin MC
Department:	Institute of Molecular Biology
Source(s) of Funding:	Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:	04/2001

Abstract:

To study basic research on systemic damage in early stage and wound-healing after severe trauma.

Project Title:	Developmental function, molecular target, and transcriptional regulation of the cold-inducible RNA binding protein
Investigator(s):	Lin MC
Department:	Institute of Molecular Biology
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	12/2001

Abstract:

To elucidate the function of XCIRP-1 in Xenopus embryonic neural development; to discover the specific down-stream target RNAs of the DCIRP-1 protein in order to understand the molecular mechanisms of the XCIRP-1 actions; to clone the promoter of human CIRP gene, characterize the transcriptional regulation, and investigate the cold- and heat-induced regulation of hCIRP gene expression in human brain- and liver-derived cell lines.

Project Title:	Basic research on the mechanism of aging and the prevention of geriatric disease
Investigator(s):	Lin MC
Department:	Institute of Molecular Biology
Source(s) of Funding:	Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:	12/2001

Abstract:

To study the mechanism of aging and the prevention of geriatric disease.

Project Title:	Characterization of a novel cell cycle related kinase in glioblastoma
Investigator(s):	Lin MC, Leung SY, Ching YP
Department:	Institute of Molecular Biology
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	12/2002

Abstract:

The project aims at characterizing the role of cell cycle related kinase (CCRK) in cell cycle control, apoptosis, cell division and cell proliferation. Potential tumorigenic function of CCRK in human glioblastoma, fibroblast cell lines, and nude mice xenograft will also be investigated.

Project Title:	Isolation and characterization of the silkworm factors that enhance the intestinal absorption/transport of orally delivered therapeutic proteins
Investigator(s):	Lin MC
Department:	Institute of Molecular Biology
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	05/2003
Completion Date:	10/2004

Abstract:

To isolate and characterize silkworm factors responsible for enhancing the intestinal absorption / transport of orally delivered protein drugs.

Project Title:	Cancer gene therapy using a novel anti-cancer polypeptide hTERTC27 delivered by a novel AAV and Adenovirus Cocktail vector system
Investigator(s):	Lin MC, Wong BCY, Kung H, Peng Y
Department:	Institute of Molecular Biology
Source(s) of Funding:	Innovation and Technology Support Programme
Start Date:	06/2003

Abstract:

To optimize our innovative, novel and patented hTERTC27 cancer gene therapy and the AAV/Adv cocktail vector technologies developed in our laboratory; to establish patented stable cell line and platforms for the large scale production of AAV-hTERTC27 and Adv-hTERTC27; to carry out, using the above, in pre-clinical study for treating solid tumors.

Project Title:	Molecular basis of alcohol-induced birth defects, the critical role of Pax 6
Investigator(s):	Lin MC, Wong BCY, Yang JY, Peng Y
Department:	Institute of Molecular Biology
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	09/2003

Abstract:

To elucidate the signaling pathways leading to alcohol-mediated inhibition of Pax6 expression and to identify the targets downstream of Pax6 responsible for microcephaly. We are particularly interested in the involvements of the PI3 kinase pathways and the reactive oxygen species and reactive nitrogen species; to investigate the molecular mechanisms for alcohol-induced growth retardation, in particular its relationship with gut development; to study alcohol induced eye deformation; to screen for agents that protect against alcohol induced birth defects.

Project Title:	Molecular basis of alcohol-induced birth defects, the critical role of Pax 6
Investigator(s):	Lin MC, Wong BCY, Yang JY, Peng Y
Department:	Institute of Molecular Biology
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2003

Abstract:

Project Title:	Molecular basis for the telomere dysfunction and anti-tumor activities of a C-terminal polypeptide of human telomerase reverse transcriptase (hTERTC27)
Investigator(s):	Lin MC, Wong BCY
Department:	Institute of Molecular Biology
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	12/2003

Abstract:

To identify the proteins which interact with hTERTC27; to charaterize the anti-tumor activity of hTERTC27 in vitro using varied TERT positive and TERT negative cell lines and stem cells; to test the efficacy of hTERTC27 cancer gene therapy against glioblastoma in vivo in nude mice xenograft using an Adeno Associated Virus and Adenovirus-based gene delivery system.

Project Title:	Development of a novel insect cell system for large scale recombinant AAV production
Investigator(s):	Lin MC, He ML
Department:	Institute of Molecular Biology
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	01/2004
Completion Date:	01/2005

Abstract:

To develop a robust, cost-effective, large-scale system for the preparation of high-titer, high-purity recombinant AAV vector sing the baculovirus and insect Sf9 cells.

Project Title:	Gene therapy for the treatment of HBV infection, HBV-induced liver cancer
Investigator(s):	Lin MC, Zheng B, Yuen KY, Kung H
Department:	Institute of Molecular Biology
Source(s) of Funding:	Innovation and Technology Support Programme
Start Date:	07/2004

Abstract:

To develop an innovative and effective gene therapies to treat HBV infection and HCC.

Project Title:	Characterization of the HNF-1 element as a novel Insulin Negative Response cis-Element (INRE) and its implication in diabetes
Investigator(s):	Lin MC
Department:	Institute of Molecular Biology
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2004

Abstract:

Refer to hard copy

Project Title:	Development of Novel AAV based anti-angiogenesis gene therapy for the treatment of liver cancer
Investigator(s):	Lin MC, Fan ST, Wong BCY, Ng SM, He ML, Gan R.B., Kung H
Department:	Institute of Molecular Biology
Source(s) of Funding:	Innovation and Technology Support Programme
Start Date:	08/2004

Abstract:

To develop an innovative and effective gene therapies to treat hepatocellular carcinoma (HCC).

Project Title:	Cancer gene therapy using a novel anti-cancer polypeptide hTERTC27 delivered by a novel AAV and Adenovirus Cocktail vector system
Investigator(s):	Lin MC, Kung H, Wong BCY
Department:	Institute of Molecular Biology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	09/2004
Completion Date:	07/2005

Abstract:

Project Title:	Characterizing the role of P13K signaling cascade in Xenopus neural induction
Investigator(s):	Lin MC
Department:	Institute of Molecular Biology
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

Refer to hard copy

List of Research Outputs

Lin M.C., Lee N., Zheng N., Yang P.H., Wong O.G., Kung H.F., Luk J.M.C. and Lau G., Tumor necrosis factor-alpha-induced protein 1 and immunity to hepatitis B virus, World J Gastroenterol. 2005.

Researcher : Liu H

List of Research Outputs

Liu H., Lau C.P. and Li G.R., EGFR protein tyrosine kinase dependent modulation of voltage-gated sodium current in guinea pig ventricular myocytes, Journal of Hong Kong College Cardiology. 2004, 12(3/4):: P14.

Researcher : Lo LF

List of Research Outputs

Cheung B.M.Y., Lam T.H., Lam K.S.L., Tam S., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Man Y.B., Cheng C.H., Kumana C.R. and Lau C.P., Follow Up of the Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., High Blood Pressure is Related to Obesity in Hong Kong, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Lipid Profile of the Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Obesity in the Hong Kong Cardiovascular Risk Factor Prevalence Survey-2 (CRISPS2) Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of Diabetes Mellitus (DM) in the Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Wat N.M.S., Lo L.F., Chau F.Y., Lam T.H., Leung G.M., Tam S., Cheng C.H., Kumana C.R., Lau C.P. and Lam K.S.L., Prevalence of Hypertension in Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort, J Hong Kong Coll Cardiol. 2004, 12: 33.

Cheung B.M.Y., Lo L.F., Fong D.Y.T., Chan M.Y., Wong W.H.S., Lau C.P., Lam K.S.L., Wong V.C.N. and Karlberg J.P.E., Randomised Controlled Trial of Qigong in Hypertension, Cardiovasc Drugs Thera. 2004, 28 (suppl) 1: 28.

Cheung B.M.Y., Lo L.F., Fong D.Y.T., Chan M.Y., Wong W.H.S., Lau C.P., Lam K.S.L., Wong V.C.W. and Karlberg J.P.E., Randomised controlled trial of qigong in hypertension, J Hong Kong Coll Cardiol. 2004, 12: 34.

Cheung B.M.Y., Lo L.F., Fong D.Y.T., Chan M.Y., Wong S.H.T., Wong V.C.W., Lam K.S.L., Lau C.P. and Karlberg J.P.E., Randomised controlled trial of qigong in the treatment of mild essential hypertension, J Hum Hypertens. 2005, 19(9): 697-704.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Relationship Between Hypertension and Obesity in Hong Kong, 3rd Asian-Pacific Congress on Hypertension, Singapore 2004.

Man Y.B., Cheung B.M.Y., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of Hypertension in the Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong. 2004.

Researcher : Lo WK

List of Research Outputs

Lam M.F., Yip P.S., Leung J.C.K., Chan D.T.M., Lo W.K. and Lai K.N., Mannose binding lectin gene mutation and incidence rate of peritonitis in long-term peritoneal dialysis patients, Journal of American Society of Nephrology. 2004, 15: 598A.

Lam M.F., Lo W.K., Chu F.S., Li F.K., Yip T.P., Tse K.C., Chan D.T.M. and Lai K.N., Retroperitoneal leakage as a cause of ultrafiltration failure, Peritoneal Dialysis International. 2004, 24(5): 466-470.

Lo W.K., Lui S.L., Chan D.T.M., Li F.K., Lam M.F., Tse K.C., Tang C.S.O., Choy C.B.Y. and Lai K.N., Minimal and optimal peritoneal Kt/V targets: results of an anuric peritoneal dialysis patient's survival analysis. , Kidney International. 2005, 67(5): 2032-2038.

Lui S.L., Cheng S.W., Ng E., Yip P.S., Tse K.C., Lam M.F., Lai K.N. and Lo W.K., A randomized prospective comparison of intraperitoneal cefazolin plus netilimicin versus cefazolin plus ceftazidime in the treatment of CAPD peritonitis, Nephrology Dialysis Transplantation. 2005, 10 (suppl): A68.

Lui S.L., Wong R.W.M., Ng S.Y., Chan D.T.M., Lai K.N. and Lo W.K., Seroprevalence of Helicobacter pylori in Chinese patients on continuous ambulatory peritoneal dialysis , Nephrology. 2005, 10(1): 21-24.

Lui S.L., Yip P.S., Tse K.C., Lam M.F., Li F.K., Lai K.N. and Lo W.K., Simultaneous removal and reinsertion of peritoneal dialysis catheters for the treatment of refractory pseudomonas exit site infection in CAPD patients, Nephrology. 2005, 10(suppl): A68.

Lui S.L., Tang S., Li F.K., Choy C.B.Y., Chan D.T.M., Lo W.K. and Lai K.N., Tuberculous infection in southern Chinese renal transplant recipients, Clinical transplantation. 2004, 18(6): 666-671.

Researcher : Lo Y

List of Research Outputs

Mok T.M.Y., Chan E.Y.T., Lo Y., Wong R.W.S. and Lau W.C.S., Antiphospholipid (aPL) antibody profiles in Chinese patients with systemic lupus erythematosus, 11th APLAR Bi-annual Congress, Jeju, Korea 11-16 September 2004.

Mok T.M.Y., Leung P.Y., Lao T.T.H., Lo Y., Chan D.T.M., Wong R.W.S. and Lau W.C.S., Clinical predictors of fetal and maternal outcome in Chinese patients with systemic lupus erythematosus, 11th APLAR Bi-annual Congress, Jeju, Korea 11-16 September 2004.

Mok T.M.Y., Leung P.Y., Lao T.T.H., Lo Y., Chan D.T.M., Wong W.S. and Lau W.C.S., Clinical predictors of fetal and maternal outcome in Chinese patients with systemic lupus erythematosus, Annals Of The Rheumatic Diseases. 2004, 63: 1705-1706.

Mok T.M.Y., Lo Y., Leung P.Y. and Lau W.C.S., Pregnancy outcome in patients with adult onset Still's disease, Journal of Rheumatology. 2004, 31(11): 2307-2309.

Mok T.M.Y., Lo Y., Chan D.T.M., Wong R.W.S. and Lau W.C.S., Tuberculosis in systemic lupus erythematosus in an endemic area and the role of isoniazid prophylaxis during corticosteroid therapy. , Journal of rheumatology. 2005, 32(4): 609-615.

Researcher : Lok-Chu EMY

List of Research Outputs

Lok-Chu E.M.Y., Chiu P.K.Y., Wong R.W.S., Tang W.M., Tang W.M. and Lau W.C.S., Translation and validation of arthritis impact measurement scales 2 into Chinese: CAIMS2, Arthritis Care & Research. 2004, 51(1): 20-27.

Researcher : Lu M

List of Research Outputs

Gisselsson D.L., Lu M., Tsao G.S.W., Man C.W.Y., Jin C., Jin C., HOglund M., Kwong Y.L. and Jin Y., Telomere-mediated mitotic disturbances in immortalized ovarian epithelial cells reproduce chromosomal losses and breakpoints from ovarian carcinoma, Genes, Chromosomes and Cancer. 2004, 42(1): 22-23.

Jin Y., Jin C., Lu M., Tsao G.S.W., Zhu J., Wennerberg J., Mertens F. and Kwong Y.L., Karyotypic evolution and tumor progression in head and neck squamous cell carcinomas , Cancer Genetics and Cytogenetics . 2005, 156(1): 1-7.

Researcher : Lui SL

List of Research Outputs

Lai K.N., Chan L.Y., Tang S.C.W., Tsang W.L., Li F.K., Lam M.F., Lui S.L. and Leung J.C.K., Mesangial expression of angiotensin II receptor in IgA nephropathy and its regulation by polymeric IgA1 , Kidney International. 2004, 66: 1403-1416.

Lam M.F., Yip T.P.S., Tse K.C., Li F.K., Lui S.L., Lai K.N. and Chan D.T.M., Sirolimus in kidney transplantation: a pilot study in Chinese patients, Hong Kong Journal of Nephrology. Hong Kong, 2004, 6(1): 38-42.

Li P.K., Weening J.J., Dirks J., Lui S.L., Szeto C.C., Tang S.C.W., Atkins R.C., Mitch W.E., Chow K.M., D'Amico G., Freedman B.I., Harris D.C., Hooi L.S., Jong P.E., Kincaid-Smith P. and Lai K.N., A report with consensus statements of the International Society of Nephrology 2004 Consensus Workshop on Prevention of Progression of Renal Disease, Hong Kong, June 29, 2004 , Kidney International. 2005, 67(suppl 94): S2-S7.

Lo W.K., Lui S.L., Chan D.T.M., Li F.K., Lam M.F., Tse K.C., Tang C.S.O., Choy C.B.Y. and Lai K.N., Minimal and optimal peritoneal Kt/V targets: results of an anuric peritoneal dialysis patient's survival analysis. , Kidney International. 2005, 67(5): 2032-2038.

Lui S.L., Cheng S.W., Ng E., Yip P.S., Tse K.C., Lam M.F., Lai K.N. and Lo W.K., A randomized prospective comparison of intraperitoneal cefazolin plus netilimicin versus cefazolin plus ceftazidime in the treatment of CAPD peritonitis, Nephrology Dialysis Transplantation. 2005, 10 (suppl): A68.

Lui S.L., Chan D.T.M. and Lai K.N., Au update on immunosuppressive drugs for renal transplantation, Medical Progress. Hong Kong, 2005, 32(2): 57-63.

Lui S.L., Wong R.W.M., Ng S.Y., Chan D.T.M., Lai K.N. and Lo W.K., Seroprevalence of Helicobacter pylori in Chinese patients on continuous ambulatory peritoneal dialysis , Nephrology. 2005, 10(1): 21-24.

Lui S.L., Yip P.S., Tse K.C., Lam M.F., Li F.K., Lai K.N. and Lo W.K., Simultaneous removal and reinsertion of peritoneal dialysis catheters for the treatment of refractory pseudomonas exit site infection in CAPD patients, Nephrology. 2005, 10(suppl): A68.

Lui S.L., Tang S., Li F.K., Choy C.B.Y., Chan D.T.M., Lo W.K. and Lai K.N., Tuberculous infection in southern Chinese renal transplant recipients, Clinical transplantation. 2004, 18(6): 666-671.

Tang S.C.W., Lui S.L. and Lai K.N., Pathogenesis of lupus nephritis: an update , Nephrology. 2005, 10: 174-179.

Researcher : Mak JCW

Project Title:	Serum cytokine levels in convalescent patients with severe acute respiratory syndrome (SARS)
Investigator(s):	Mak JCW, Tsang KWT, Lam WK, Lai KN
Department:	Medicine
Source(s) of Funding:	VCO SARS Research Fund
Start Date:	07/2003

Abstract:

To measure a panel of cytokines, including the T helper 1 (Th1) cytokine interferon-gamma (INF-gamma), and the Th2 cytokines interleukin-4 (IL-4), IL-5, IL-6, and granulocyte-macrophage colony-stimulating factor (GM-CSF) in frozen sera from SARS patients in comparison to healthy control subjects.

Project Title:	Effects of pseudomonas aeruginosa pyocyanin and 1-hydroxyphenazine on the regulation of glucocorticoid receptor activation and function in airway epithelial cells in vitro
Investigator(s):	Mak JCW, Tsang KWT
Department:	Medicine
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	11/2003

Abstract:

To evaluate the effects of Pseudomonas aeruginosa (PA) exotoxins, pyocyanin (PYO) and 1-hydroxyphenazine (1-HP), on the functional and immunological aspects of human airway epithelial cells in vitro, and examine the signaling pathways involved in PYO- or 1-HP-induced responses; to assess the efficacy of various potential novel therapeutic and chemical agents on the effects of these toxins.

Project Title:	Effects of pseudomonas aeruginosa pyocyanin and 1-hydroxyphenazine on the regulation of glucocorticoid receptor activation and function in airway epithelial cells in vitro
Investigator(s):	Mak JCW, Tsang KWT
Department:	Medicine
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	11/2003

Abstract:

Project Title:	Is there an association between TGF-[beta]₁ plasma levels and common polymorphisms with a risk of developing chronic obstructive pulmonary disease (COPD)?
Investigator(s):	Mak JCW, Tsang KWT, Chan MMW
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2004

Abstract:

To study the promoter and coding regions of the TGF-[beta]₁ gene, identify single nucleotide polymorphisms (SNP) in Hong Kong Chinese (i.e. healthy nonsmokers and smokers and patients with COPD) and correlate these with plasma TGF-[beta]₁ level.

Project Title:	Role of transforming growth factor-beta1 variants in susceptibility to tuberculosis in Hong Kong Chinese population
Investigator(s):	Mak JCW, Chan MMW
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2005

Abstract:

i) To study the role of two common single nucleotide polymorphisms (SNPs) at the promoter (C-509T) and coding regions (T869C) of the TGF-beta1 gene in conferring susceptibility to the development of tuberculosis (TB) in Hong Kong Chinese population. ii) To perform functional analysis in correlating the associated polymorphisms with the plasma level of TGF-beta1 in TB patients and healthy controls. iii) To conduct a study in determining the proportion of patients with chronic obstructive pulmonary disease (COPD) with a past history of tuberculosis since COPD is a major cause of respiratory disability in Hong Kong.

List of Research Outputs

Chan M.M.W., Lam W.K., Mak J.C.W., Ho S.P., Chan H.W., Tsang K.W.T., Ip M.S.M., Ho J.C.M., Wong M.P. and Tan-Un K., Polymorphisms of CYP and GST genes, passive smoke and lung cancer risk in Hong Kong Chinese, European Respiratory Journal. 2004, 24: Suppl 48: 457s.

Ho J.C.M., Mak J.C.W., Ho S.P., Ip M.S.M., Tsang K.W.T., Lam W.K. and Chan M.M.W., Manganese superoxide dismutase and catalase genetic polymorphisms activity levels and lung cancer risk in Chinese in Hong Kong, 10th Medical Research Conference, Department of Medicine, The University of Hong Kong, February 2005. Abstract Book: RM 66.

Ho J.C.M., Ho S.P., Chan M.M.W., Mak J.C.W., Ip M.S.M., Ko K.W., Yan C.P.K., Wong M.P., Tsang K.W.T. and Lam W.K., Non-small cell lung cancer in Chinese is associated with disturbance in systemic antioxidant profiles, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December, 2004. Respirology. 2004, 9 (Supp): A114.

Ho S.P., Chan M.M.W., Chow K.M., Ip M.S.M. and Mak J.C.W., Antioxidant enzyme activities in healthy Chinese adults: influence of age, gender, and smoking, Respirology. 2005, 10: 305-309.

Ho S.P., Chan M.M.W., Wong M.P., Tsang K.W.T., Ip M.S.M., Lam W.K. and Mak J.C.W., Transforming growth factor (TGF)-beta 1 gene common polymorphisms and plasma TGF-beta 1 levels in patients with lung cancer, 10th Medical Research Conference, Department of Medicine, The University of Hong Kong, February 2005. Abstract Book: RM 60.

Ho S.P., Chan M.M.W., Tsang K.W.T., Ip M.S.M., Lam W.K. and Mak J.C.W., Transforming growth factor (TGF)-beta 1 gene common polymorphisms and plasma TGF-beta 1 levels in patients with lung cancer, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A120.

Mak J.C.W., Ho S.P., Leung Y.H., Ho P.L., Ooi C.G.C., Yan C.P.K., Ko K.W., Ip M.S.M., Lam W.K. and Tsang K.W.T., Elevated levels of transforming growth factor- beta 1 in serum of patients with stable bronchiectasis, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A134.

Mak J.C.W., Leung C.M., Ho S.P., Law K.W., Tsang K.W.T., Lam W.K., Ip M.S.M. and Chan M.M.W., Genetic susceptibility of transforming growth factor beta-1 common polymorphisms to Chinese patients with asthma, American Thoracic Society International Conference, San Diego, USA. May 2005. Proceedings of the American Thoracic Society. 2005, p.A78.

Mak J.C.W., Ho J.C.M., Ho S.P., Yu W.C., Yew W.W., Tsang K.W.T., Lam W.K., Ip M.S.M. and Chan M.M.W., Increased oxidative stress and altered antioxidant status in Chinese patients with COPD, European Respiratory Journal. 2004, 24: Suppl 48: 62s.

Mak J.C.W., Hui W.S., Johnson M.W., Barnes P.J. and Tsang K.W.T., Modulation of Functional Pulmonary β2-Adrenoceptor by Tansforming Growth Factor-β1 in Human Bronchial Epithelial Cells, Abstract Book of the 10th Medical Research Conference, University Department of Medicine, The University of Hong Kong, 19-20 Feb. 2005, page 61.

Mak J.C.W., Ho J.C.M., Ho S.P., Leung C.M., Law K.W., Ip M.S.M. and Chan M.M.W., Polymorphisms of superoxide dismutase and catalase genes and their functional activity levels in Chinese patients with asthma, American Thoracic Society International Conference, San Diego, USA. May 2005. Proceedings of the American Thoracic Society . 2005, p.A78.

Mak J.C.W., Leung H.C., Ho S.P., Lam W.K., Tsang K.W.T., Ip M.S.M. and Chan M.M.W., Systemic antioxidant status in Chinese patients with asthma, European Respiratory Journal. 2004, 24: Suppl 48: 509s.

Mak J.C.W., Leung C.M., Ho S.P., Lam W.K., Tsang K.W.T., Ip M.S.M. and Chan M.M.W., Systemic oxidative and antioxidative status in Chinese patients with asthma, Journal of Allergy and Clinical Immunology. 2004, 114(2): 260-264.

Pan N.Y., Hui W.S., Tipoe G.L., Tsang K.W.T. and Mak J.C.W., Effects of Glucocorticosteroids and Antimicrobial Drugs on Inhibition of IL-1β- and PDBu-induced IL-8 Release in the Presence of Pyocyanin in Bronchial Epithelial Cell Line, Abstract Book of the 10th Medical Research Conference, University Department of Medicine, The University of Hong Kong, 19-20 February. 2005, page 62.

Tsang K.W.T., Tipoe G.L., Mak J.C.W., Sun J.Z., Wong M.P., Leung R.C.M., Tan K.C.B., MedStat C.K.M., Ho J.C.M., Ho P.L., Rutman A. and Lam W.K., Ciliary central microtubular orientation is of no clinical significance in bronchiectasis, Respiratory Medicine. 2005, 99: 290-297.

Tsang K.W.T., Tan K.C.B., Ho P.L., Ooi C.G.C., Khong P.L., Leung Y.H., Mak J.C.W., Tipoe G.L., Ko K.W. and Lam W.K., Exhaled nitric oxide in bronchiectasis: the effects of inhaled corticosteroid therapy, International Journal of Tuberculosis and Lung Disease. 2004, 8(11): 1301-1307.

Tsang K.W.T., Tan K.C.B., Ho P.L., Ooi C.G.C., Ho J.C., Mak J.C.W., Tipoe G.L., Ko C., Yan C. and Lam W.K., Inhaled fluticasone in bronchiectasis: a 12 month study, Thorax. 2005, 60: 239-243.

Researcher : Mak W

List of Research Outputs

Au W.Y., Mak W., Ho S.L., Leung S.Y. and Kwong Y.L., Reversible paraneoplastic neuropathy associated with T-cell large granular lymphocyte leukemia, Neurology. 2004, 63(3): 588-589.

Au W.Y., Lie A.K.W., Kung A.W.C., Mak W. and Kwong Y.L., Thyrotoxic periodic paralysis after allogeneic haematopoietic stem cell transplantation, British Journal of Haematology. 2005, 129(1): 160.

Chan K.H., Cheung R.T.F., Au Yeung K.M., Mak W., Cheng T.S. and Ho S.L., A lady with suicidal history presented with speech and walking difficulties, Journal of Clinical Neuroscience. 2005, 12: 303-305.

Chan K.H., Cheung R.T.F., Mak W., Lee R., Fong C.Y., Cheng T.S. and Ho S.L., Cerebral infarction complicating tuberculous meningitis (TBM), 17th Annual Scientific Meeting, The Hong Kong Neurological Society. 2004, 10: 8.

Chan K.H., Cheung R.T.F., Lee R., Mak W., Cheng T.S. and Ho S.L., Cerebral infarcts complicating tuberculous meningitis, Cerebrovascular Diseases. 2005, 19: 391-395.

Chan K.H., Cheung R.T.F., Lui W.M., Mak W. and Ho S.L., Cerebral venous thrombosis in a gentleman with fever, convulsion and frontotemporal haemorrhages, Journal of Clinical Neuroscience. 2005, 12: 186-188.

Chan K.H., Mak W., Cheng T.S., Cheung R.T.F. and Ho S.L., Natural course of patients with acute myelitis, 17th Annual Scientific Meeting, The Hong Kong Neurological Society. 2004, 10: 6.

Chan K.H., Cheung R.T.F., AuYeung K.M., Mak W. and Ho S.L., Wilson's Disease With Depression And Parkinsonism., J Clin Neurosci. 2005, 12(3): 303-5.

Ho W.L., Chan Y.L., Kwok H.H., Mak W., Chu A.C.Y., Kung M.H.W., Ramsden D.B. and Ho S.L., mpp+ Modulates Mitochondrial Uncoupling Protein Ucp2, Ucp4 And Ucp5 Expression In Catecholaminergic (sk-n-sh) Cells , J Neurosci Res. 2005, 81(2): 261-8.

Hon C., Mak W., Kwok A.K.H. and Au W.Y., Immunological and electrophysiological investigations of severe ptosis after bone marrow transplantation, Bone Marrow Transplantation. 2004, 34(5): 455-458.

Mak W., Chan K.H. and Ho S.L., A Case Of Ocular Myasthenia Gravis And Miller Fisher Syndrome, Hospital Medicine. 2005, 66(2): 116-7.

Mak W., Tsang K.L., Tsoi T.H., AuYeung K.M.A., Chan K.H., Cheng T.S., Cheung R.T.F. and Ho S.L., Bath-related Headache, Cephalalgia. 2005, 25(3): 191-8.

Mak W., Chan K.H., Cheung R.T.F. and Ho S.L., Hypertensive encephalopathy: BP lowering complicated by posterior circulation ischemic stroke, Neurology. 2004, 63: 1131-1132.

Mak W., Cheung R.T.F. and Ho S.L., Racial/ethnic differences in cerebrovascular disease – HK perspective, Hong Kong Stroke Symposium & Workshop 2004. 5: 42-46.

Mak W., Cheung R.T.F. and Ho S.L., Riches-Cannieu anastomosis: an electrophysiology study in Hong Kong Chinese and its implications in carpal tunnel syndrome, 17th Annual Scientific Meeting, The Hong Kong Neurological Society. 2004, 10: 11.

Mak W., Cheung R.T.F. and Ho S.L., Why is intracranial large-artery steno-occlusive disease more common in Asians? A human evolutionary hypothesis and its implications, 17th Annual Scientific Meeting, The Hong Kong Neurological Society. 2004, 10: 29.

Mak W., Tsang K.L., Tsoi T.H., Au Yeung K.M., Chan K.H., Cheng T.S., Cheung R.T.F. and Ho S.L., “Thundery Shower”: a novel headache syndrome, 17th Annual Scientific Meeting, The Hong Kong Neurological Society. 2004, 10: 30.

Researcher : Man CWY

List of Research Outputs

Gisselsson D.L., Lu M., Tsao G.S.W., Man C.W.Y., Jin C., Jin C., HOglund M., Kwong Y.L. and Jin Y., Telomere-mediated mitotic disturbances in immortalized ovarian epithelial cells reproduce chromosomal losses and breakpoints from ovarian carcinoma, Genes, Chromosomes and Cancer. 2004, 42(1): 22-23.

Researcher : Man YB

List of Research Outputs

Cheung B.M.Y., Man Y.B., Tse H.F., Kumana C.R. and Lau C.P., Advantages of Blood Pressure Optimisation Study, J Hong Kong Coll Cardiol . 2004, 12: 33.

Cheung B.M.Y., Leung Y.H., Man Y.B., Wong L.Y.F. and Lau C.P., Association of Blood Pressure and Obesity with a Single Nucleotide Polymorphism at 17p12, American Journal of Hypertension. 2005, 18(5) Suppl: A79.

Cheung B.M.Y., Leung Y.H., Man Y.B. and Lau C.P., Association of Essential Hypertension with the WNK4 Gene, the Molecular Switch Controlling Renal Sodium and Potassium Excretion, Cardiovasc Drugs Thera. 2004, 18 (Suppl) 1: 8.

Cheung B.M.Y., Man Y.B., Leung Y.H. and Wong L.Y.F., Association of Single Nucleotide Polymorphisms in the Urotensin II Gene with Plasma Insulin and Hypertension, American Journal of Hypertension. 2005, 18: 79A.

Cheung B.M.Y., Leung Y.H., Man Y.B. and Wong L.Y.F., Elevated Plasma Concentration of Urotensin II in Hypertension, 3rd Asian-Pacific Congress on Hypertension, Singapore 2004.

Cheung B.M.Y., Leung Y.H., Man Y.B. and Wong L.Y.F., Elevated Plasma Concentration of Urotensin II in Hypertension, J Hypertens. 2004, 22 (Suppl 2): S188.

Cheung B.M.Y., Lam T.H., Lam K.S.L., Tam S., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Man Y.B., Cheng C.H., Kumana C.R. and Lau C.P., Follow Up of the Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., High Blood Pressure is Related to Obesity in Hong Kong, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Lipid Profile of the Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Obesity in the Hong Kong Cardiovascular Risk Factor Prevalence Survey-2 (CRISPS2) Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Leung Y.H., Man Y.B. and Wong L.Y.F., Plasma Concentration of Urotensin II is Raised in Hypertension, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong. 2004.

Cheung B.M.Y., Leung Y.H., Man Y.B. and Wong L.Y.F., Plasma Concentration of Urotensin II is Raised in Hypertension, J Hypertens. 2004, 22: 1341-4.

Cheung B.M.Y., Man Y.B., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of Diabetes Mellitus (DM) in the Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Wat N.M.S., Lo L.F., Chau F.Y., Lam T.H., Leung G.M., Tam S., Cheng C.H., Kumana C.R., Lau C.P. and Lam K.S.L., Prevalence of Hypertension in Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort, J Hong Kong Coll Cardiol. 2004, 12: 33.

Cheung B.M.Y., Law C.Y., Ho G.Y.Y., McGhee S.M., Man Y.B., Ng P.P.Y., Kumana C.R. and Lau C.P., Randomised Controlled Trial of Low Salt Diet Versus Drug Treatment in the Management of Mild hypertension, 8th Scientific Meeting of the Hong Kong Pharmacology Socieity in Association with the Shanghai Pharmacology Society, Hong Kong 2004.

Cheung B.M.Y., Law C.Y., Ho G.Y.Y., McGhee S.M., Man Y.B., Ng P.P.Y., Kumana C.R. and Lau C.P., Randomsed Controlled Trial of Low Salt Diet Versus Drug Treatment in Hypertension, Cardiovasc Drugs Thera. 2004, 18 (Suppl) 1: 15.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Relationship Between Hypertension and Obesity in Hong Kong, 3rd Asian-Pacific Congress on Hypertension, Singapore 2004.

Cheung B.M.Y., Lam T.H., Lam K.S.L., Tam S., Wat N.M.S., Man Y.B., Cheng C.H., Kumana C.R. and Lau C.P., The Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort - Results at 7 Years, J Hypertens. 2004, 22 (Suppl 2): S268-269.

Man Y.B., Wong L.Y.F. and Cheung B.M.Y., Association of Urotensin II rs7367534 C>T Polymorphism with Hypertension, J HK Coll Cardiol . 2004, 12: 110.

Man Y.B., Cheung B.M.Y., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of Hypertension in the Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong. 2004.

Ong K.L., Wong L.Y.F., Man Y.B., Lam K.S.L. and Cheung B.M.Y., Hypertension is associated with a single nucleotide polymorphism in the uroteinsin II gene, 10th Medical Research Conference, The University of Hong Kong. 19-20 Feb 2005.

Wong L.Y.F., Man Y.B., Leung Y.H. and Cheung B.M.Y., Interleukin-6 Gene -573G>C Promoter Polymorphism is Associated with Plasma Fibrinogen Level and Hypertension in Hong Kong Chinese, American Journal of Hypertension. 2005, 18: 186A.

Researcher : Mok TMY

List of Research Outputs

Chan D.T.M., Tse K.C., Tang C.S.O., Mok T.M.Y., Li F.K. and Hong Kong Nephrology Study G.R.O.U.P., Long-term study of mycophenolate mofetil as continuous induction and maintenance treatment for diffuse proliferative lupus nephritis, Journal of American Society of Nephrology. 2005, 16(4): 1076-1084.

Jin O., Sun L.Y., Zhou K.X., Zhang X.S., Feng X.B., Mok T.M.Y. and Lau W.C.S., Lymphocyte apoptosis and macrophage function: correlation with disease activity in systemic lupus erythematosus, Clinical Rheumatology. 2005, 24: 107-110.

Jin O., Chan W.K., Mok T.M.Y., Sun L.Y. and Lau W.C.S., Osteopontin (OPN), matrix metalloproteinase (MMP)-3 and lupus nephritis (LN), 11th APLAR Bi-annual Congress, Jeju, Korea 11-16 September 2004.

Lau W.C.S., Chung E.K., Zhou B., Wu Y.L., Yang Y., Mok T.M.Y., Ip E.W.K., Wong W.H.S., Lau Y.L. and Yu C.Y., C4A gene deficiency in Chinese patients with systemic lupus erythematosus (SLE), 11th APLAR Bi-annual Congress, Jeju, Korea 11-16 September 2004.

Lau W.C.S., Chung E.K., Zhou B., Wu Y.L., Yang Y., Mok T.M.Y., Ip E.W.K., Wong W.H.S., Lau Y.L. and Yu C.Y., Genotypic and phenotypic analyses of C4A and C4B in Chinese patients with systemic lupus erythematosus (SLE), 11th APLAR Bi-annual Congress, Jeju, Korea 11-16 September 2004.

Mok T.M.Y., Chan E.Y.T., Lo Y., Wong R.W.S. and Lau W.C.S., Antiphospholipid (aPL) antibody profiles in Chinese patients with systemic lupus erythematosus, 11th APLAR Bi-annual Congress, Jeju, Korea 11-16 September 2004.

Mok T.M.Y., Chan E.Y.T., Fong D.Y.T., Leung K.F.S., Wong W.S. and Lau W.C.S., Antiphospholipid Antibody Profiles and Their Clinical Associations in Chinese Patients with Systemic Lupus Erythematosus, The Journal of Rheumatology. 2005, 32 (4): 622-8.

Mok T.M.Y., Leung P.Y., Lao T.T.H., Lo Y., Chan D.T.M., Wong R.W.S. and Lau W.C.S., Clinical predictors of fetal and maternal outcome in Chinese patients with systemic lupus erythematosus, 11th APLAR Bi-annual Congress, Jeju, Korea 11-16 September 2004.

Mok T.M.Y., Leung P.Y., Lao T.T.H., Lo Y., Chan D.T.M., Wong W.S. and Lau W.C.S., Clinical predictors of fetal and maternal outcome in Chinese patients with systemic lupus erythematosus, Annals Of The Rheumatic Diseases. 2004, 63: 1705-1706.

Mok T.M.Y., Interpreting Abnormal Laboratory Findings: Autoantibodies , 9th Hong Kong Medical Forum. 2004.

Mok T.M.Y., Lo Y., Leung P.Y. and Lau W.C.S., Pregnancy outcome in patients with adult onset Still's disease, Journal of Rheumatology. 2004, 31(11): 2307-2309.

Mok T.M.Y., Lo Y., Chan D.T.M., Wong R.W.S. and Lau W.C.S., Tuberculosis in systemic lupus erythematosus in an endemic area and the role of isoniazid prophylaxis during corticosteroid therapy. , Journal of rheumatology. 2005, 32(4): 609-615.

Researcher : Mok WYW

List of Research Outputs

Lam B., Sam K., Mok W.Y.W., Lam J.C., Yam L.Y.C., Lam W.K. and Ip M.S.M., A randomized study of three non-surgical treatment options in mild to moderate obstructive sleep apnea, American Thoracic Society International Conference, San Diego, USA. May 2005. Proceedings of the American Thoracic Society. 2005, p.A303.

Mok W.Y.W., Lam C.L.K., Lam B., Cheung M.T., Yam L. and Ip M.S.M., A Chinese version of the Sleep Apnea Quality of Life Index was evaluated for reliability, validity and responsiveness, Journal of Clinical Epidemiology. 2004, 57: 470-478.

Researcher : Ng HP

List of Research Outputs

Ng H.P. and Kung A.W.C., Induction of autoimmune thyroiditis and hypothyroidism by immunization of thyroid peroxides (TPO) immunodominant peptide in a mouse model, The Endocrine Society’s 87th Annual Meeting, June 4-7, 2005, San Diego, USA. 2005.

Researcher : Ng MMT

List of Research Outputs

Hui C.K., Lai K.C., Wong R.W.M., Yuen R.M.F., Ng M.M.T., Chan C.K., Hu H.C., Cheung W.W., Lai C.L. and Wong B.C.Y., Outpatients Undergoing Therapeutic Endoscopic Retrograde Cholangiopancreatography: Six-hour Versus Overnight Observation , Journal of Gastroenterology and Hepatology. 2004, 19: 1163-1168.

Luk H.H., Pang J., Li L.S.W. and Ng M.M.T., Use of Antiplatelet Drugs in the Stroke Unit of a Hong Kong Hospital, Pharmacy World & Science . 2005, 27(3): 258-262.

Researcher : Ng MYM

List of Research Outputs

Lau H.L., Ng M.Y.M., Ho A.Y.Y., Luk K.D.K. and Kung A.W.C., Genetic and environmental determinants of bone mineral density in Chinese women, 26th Annual Meeting of the American Society for Bone & Mineral Research, October 1-5, 2004, Seattle, USA. Journal of Bone and Mineral Research. 2004, 19(Supl 1): M161.

Lau H.L., Ng M.Y.M., Ho A.Y.Y., Luk K.D.K. and Kung A.W.C., Genetic and environmental determinants of bone mineral density in Chinese women, Bone. 2005, 36(4): 700-9.

Researcher : Ngai WS

List of Research Outputs

Yuen R.M.F., Kim J., Averett D., Wong D.K.H., Kim C.R., Kerr B., Ngai W.S., Yuen J.C.H. and Lai C.L., Phase I/II double-blind, randomized, placebo-controlled study of the novel anti-HBV agent LB80380/ANA380 in patients with chronic HBV infection., 55th Annual Meeting of the American Association for the Study of Liver Diseases, Boston, USA 29 Oct-2 Nov 2004 (Published in Hepatology). 2004, 40 (4 Suppl 1): 172A.

Researcher : Ong KL

List of Research Outputs

Ong K.L., Wong L.Y.F., Man Y.B., Lam K.S.L. and Cheung B.M.Y., Hypertension is associated with a single nucleotide polymorphism in the uroteinsin II gene, 10th Medical Research Conference, The University of Hong Kong. 19-20 Feb 2005.

Ong K.L., Cheung B.M.Y. and Lam K.S.L., Urotensin II and the Circulatory System, Hong Kong J Nephrol . 2005, 7: 9-14.

Ong K.L., Lam K.S.L. and Cheung B.M.Y., Urotensin II: Its Function in Health and Its Role in Disease, Cardiovascular Drugs Therapy. 2005, 19(1): 65-75.

Researcher : Pan NY

List of Research Outputs

Pan N.Y., Hui W.S., Tipoe G.L., Tsang K.W.T. and Mak J.C.W., Effects of Glucocorticosteroids and Antimicrobial Drugs on Inhibition of IL-1β- and PDBu-induced IL-8 Release in the Presence of Pyocyanin in Bronchial Epithelial Cell Line, Abstract Book of the 10th Medical Research Conference, University Department of Medicine, The University of Hong Kong, 19-20 February. 2005, page 62.

Researcher : Pang AWK

List of Research Outputs

Au W.Y., Ma E.S.K., Lam V.M.S., Chan L.C., Pang A.W.K. and Kwong Y.L., Glucose 6-phosphate dehydrogenase (G6PD) deficiency in elderly Chinese women heterozygous for G6PD variants, American Journal of Medical Genetics Part A. 2004, 129A(2): 208 - 211.

Au W.Y., Chan C., Pang A., Lie A.K.W., Liang R.H.S., Yuen P.W., Shek T.W.H., Kwong Y.L. and Pang A.W.K., Nonhematologic malignancies after allogeneic hematopoietic stem cell transplantation: incidence and molecular monitoring, Bone Marrow Transplantation. 2004, 34: 981-985.

Au W.Y., Chim J.C.S., Lie A.K.W., Leung A.Y.H., Tse E.W.C., Ma S.Y., Liang R.H.S., Pang A.W.K., Kumana C.R. and Kwong Y.L., Treatment of relapsed acute promyelocytic leukemia by arsenic-based strategies without hematopoietic stem cell transplantation in Hong Kong: a seven-year experience, American Society of Haematology Annual Scientific Meeting. 2004.

Pang A.W.K., Au W.Y. and Kwong Y.L., Caveolin-1 gene is coordinately regulated with the multidrug resistance 1 gene in normal and leukemic bone marrow , Leukemia Research . 2004, 28(9): 973-977.

Researcher : Pang RWC

List of Research Outputs

Pang R.W.C., Lee K.W., Man K., Poon R.T.P., Fan S.T., Kwong Y.L. and Tse E.W.C., RNAi-mediated silencing of PIN1 inhibits HCC tumorigenicity (Abstract) , The 96th Annual Meeting of the American Association for Cancer Research, Anaheim, California, U.S.A., 16-20 April 2005.

Researcher : Pang WC

List of Research Outputs

Pang W.C., Lee K.W., Man K., Poon R.T.P., Fan S.T., Kwong Y.L. and Tse E.W.C., Inhibition of hepatocellular carcinoma tumourigenicity by RNAi-mediated PIN1 silencing (Abstract), The 6th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 8 January 2005.

Pang W.C., Lee K.W., Man K., Poon R.T.P., Fan S.T., Kwong Y.L. and Tse E.W.C., RNAi-mediated PIN1 silencing inhibits HCC trumourigenicity (Abstract), Asian Journal of Surgery. 2005, 28(Suppl 2): S84.

Pang W.C., Lee K.W., Man K., Poon R.T.P., Fan S.T., Kwong Y.L. and Tse E.W.C., RNAi-mediated PIN1 silencing inhibits HCC tumourigenicity (Abstract), The 4th International Meeting on Hepatocellular Carcinoma: Eastern and Western Experiences, Hong Kong, 14-16 December 2004.

Pang W.C., Lee K.W., Man K., Poon R.T.P., Fan S.T., Kwong Y.L. and Tse E.W.C., RNAi-mediated silencing of PIN1 inhibits HCC tumorigenicity, The 11th Hong Kong International Cancer Congress, Hong Kong, 10-12 November, 2004.

Researcher : Pei Z

List of Research Outputs

Pei Z. and Cheung R.T.F., Pretreatment with melatonin exerts anti-inflammatory effects against ischemia/reperfusion injury in a rat middle cerebral artery occlusion stroke model, Journal of Pineal Research. 2004, 37: 85-91.

Researcher : Ren Y

Project Title:	Lipopolysaccharide (LPS) potentiates phagocyte clearance of neutrophils undergoing apoptosis
Investigator(s):	Ren Y, Savill J.
Department:	Surgery
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	01/2003
Completion Date:	12/2004

Abstract:

The project aims at dissecting the role of lipopolysaccharide (LPS) in modulating phagocytosis of apoptotic neutrophils (PMN) by macophage.

Project Title:	Proteomics computational analysis of Severe Acute Respiratory Syndrome
Investigator(s):	Ren Y, Tam PKH, Peiris JSM, He Q, Fan J.Q.
Department:	Surgery
Source(s) of Funding:	VCO SARS Research Fund
Start Date:	07/2003

Abstract:

To investigate by using proteomics approach, combining Western blotting and ELISA: (a) identification of specific pattern in serum for the diagnosis and prognosis, (b) detection of immune-relevant proteins in SARS, (c) detection of proteins in different stages of SARS patients, (d) proteome analysis of SCV (proteome maps), (e) detection of expression patterns in virus infected cells.

Project Title:	Combined laser capture microdissection and proteomic approaches for the identification of invasiveness and metastasis-specific protein markers in esophageal squamous cell carcinoma
Investigator(s):	Ren Y, Law SYK, Wong J
Department:	Surgery
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2004
Completion Date:	01/2005

Abstract:

To apply LCM to procure esophageal carcinoma cells from primary, invasive and metastatic tumor tissues, respectively, and to define invasive and metastatic - specific and normal-specific protein markers by proteomics. Such studies would greatly facilitate our understanding of invasiveness and metastatic properties of ESCC.

List of Research Outputs

Researcher : Rong R

List of Research Outputs

Rong R., Xu A., Cheung B.M.Y., Cheung G. and Lam K.S.L., Identification of Three Novel Missense Mutations of the Human Melanocortin-4 Receptor Gene in a Chinese Obesity Population, Endocrine Society's 86th Annual Meeting, New Orleans 2004.

Tso A.W.K., Wat N.M.S., Xu A., Sham P.C., Rong R., Cheng K.Y., Fong H.Y., Janus E.D. and Lam K.S.L., The adiponectin gene G276T polymorphism is a risk factor for the development of the metabolic syndrome over a period of 5 years in southern Chinese, 12th International Congress of Endocrinology, Aug 31 – Sep 4, 2004, Lisbon, Portugal. 2004, 318 P949.

Wat N.M.S., Tso A.W.K., Xu A., Sham P.C., Rong R., Cheng K.Y., Fong H.Y., Janus E.D. and Lam K.S.L., The adiponectin gene T45G polymorphism is associated with central obesity and persistent glucose intolerance in high-risk Chinese subjects over 5 years, 12th International Congress of Endocrinology, Aug 31 – Sep 4, 2004, Lisbon, Portugal. 2004.

Researcher : Sham ASK

List of Research Outputs

Woo J., Lau E..., Lee P., Kwok T..., Lau W.C.S., Chan C., Chiu P.K.Y., Li E..., Sham A.S.K. and Lam D..., Impact of osteoarthritis on quality of life in a Hong Kong Chinese population, Journal of Rheumatology. 2004, 31: 2433-2438.

Researcher : Shen J

Project Title:	Cholesterol homeostasis and oxidative stress: implication for neuronal oxidative damage in ischemia stroke
Investigator(s):	Shen J, Fung PCW, Liu K.J.
Department:	Medicine
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2003

Abstract:

To understand the roles of plasma membrane cholesterol homeostasis in neuronal oxidative damage of ischemia stroke.

Project Title:	Effects of Buyang Huanwu Decoction on neuronal regeneration after ischemic brain injury
Investigator(s):	Shen J, Fung PCW, Tong L.
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2004

Abstract:

To evaluate the effects of Buyang Huanwu Decoction, a classical formula of Traditional Chinese Medicine (TCM), and its major component Astragalus membranaceus on the regeneration of neurons after ischemic brain injury.

Project Title:	Plasma membrane cholesterol homeostasis and oxidative stress: implication for neuronal oxidative damage in ischemia stroke
Investigator(s):	Shen J, Cheung RTF, Fung PCW, Liu K.J.
Department:	Medicine
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	01/2005

Abstract:

To investigate the reole of plasma membrane cholesterol in regulating cellular oxygen supply and ROS production in MCAO ischemia-reperfused model; to investigate which cholesterol pools, free cholesterol, choelsterol ester or oxysterols, would aggravate neuronal oxidative damage in ischemia-reperfused neuronal cells; to test the hypothesis that caveolin-1 may be a important target protein linking with neuronal oxidative damage and abnormal choletserol metabolism.

Project Title:	Plasma membrane cholesterol homeostasis and oxidative stress: implication for neuronal oxidative damage in ischemia stroke
Investigator(s):	Shen J
Department:	Medicine
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

Refer to hard copy

List of Research Outputs

Lam K.S.L., Dan Q., Xu A., Shen J., Cheng K.Y. and Xu J., Adiponectin stimulates the production o fmaganese superoxide dismutase (SOD2) in human aortic smooth muscle cells, 12th International Congress of Endocrinology, Aug 31 – Sep 4, 2004, Lisbon, Portugal. 2004, A442(1242).

Ren J., Shen J., Chang C., Chan F.H.Y. and Fung P.C.W., Extraction of Nitric Oxide EPR Spectra from Mixture Spectra, 9th International Meeting and Workshop on EPR Studies of Viable Systems and Related Techniques. Hanover, USA, 2004.

Researcher : Shiu SWM

List of Research Outputs

Tan K.C.B., Shiu S.W.M., Wong Y. and Tam S., Plasma phospholipid transfer protein activity and subclinical inflammation in type 2 diabetes mellitus, Atherosclerosis. 2005, 178(2): 365-70.

Researcher : Sin PY

List of Research Outputs

Sin P.Y., Tse H.F., Siu C.W., Tsang V.Y.C., Lam C.L.K. and Lau C.P., Impairment of quality-of-life in patients with atrial fibrillation. In Tse HF, Tse TF, Lau CP, Woo KS(eds), First Global Conference on Cardiovascular Clinical Trials and Pharmacotherapy - 2nd WHF Global Conference on Cardiovascular Clinical Trials and 13th International Society of Cardiovascular Pharmacotherapy Congress. Italy, Monduzzi Editore, 2005, 45-50.

Sin P.Y., Lau C.P. and Tse H.F., Quality of life in patients with atrial fibrillation., J HK Coll Cardiol. 2005, 13: 10-15.

Sin P.Y., Tse H.F., Siu C.W., Tsang V.Y.C., Lam C.L.K. and Lau C.P., Successful pulmonary vein isolation using transvenous catheter cryoablation improves quality-of-life in patients with atrial fibrillation. In Tse HF, Tse TF, Lau CP, Woo KS (eds):, First Global Conference on Cardiovascular Clinical Trials and Pharmacotherapy - 2nd WHF Global Conference on Cardiovascular Clinical Trials and 13th International Society of Cardiovascular Pharmacotherapy Congress. Italy, Monduzzi Editore, 2005, 51-56.

Tse H.F., Tsang V.Y.C., Lam C.L.K., Lau C.P., Sin P.Y. and Siu C.W., Successful pulmonary vein isolation using transvenous catheter cryoablation improves quality-of-life in patients with atrial fibrillation, Pacing Clin Electrophysiol. 2005, 28(5): 421-4.

Researcher : Siu SC

List of Research Outputs

Xu J., Dan Q., Chan V.N.Y., Wat N.M.S., Tam S., Tiu S.C., Lee K.F., Siu S.C., Tsang M.W., Fung L.M., Chan K.W. and Lam K.S.L., Genetic and Clinical Characteristics of Maturity-onset Diabetes of the Young in Chinese Patients, European Journal of Human Genetics. 2005, 13: 422-427.

Researcher : Sum SM

List of Research Outputs

Sum S.M., Wong D.K.H., Yuen R.M.F., Yuen H., Yu J., Lai C.L., Ho D. and Zhang L., Real-time PCR Assay Using Molecular Beacon for Quantitation of Hepatitis B Virus DNA, Journal of Clinical Microbiology. 2004, 42: 3438-3440.

Wong D.K.H., Yuen R.M.F., Tse E.W.C., Yuan H., Sum S.M., Hui C.K. and Lai C.L., Detection of Intrahepatic Hepatitis B Virus DNA and Correlation with Hepatic Necroinflammation and Fibrosis, Journal of Clinical Microbiology. 2004, 42: 3920-3924.

Wong D.K.H., Yuen R.M.F., Yuan H., Sum S.M., Hui C.K., Hall J. and Lai C.L., Quantitation of Covalently Closed Circular Hepatitis B Virus DNA in Chronic Hepatitis B Patients, Hepatology. 2004, 40: 727-737.

Yuan H., Yuen R.M.F., Wong D.K.H., Sum S.M. and Lai C.L., Clinical Evaluation of the Digene Hybrid Capture II Test and the COBAS AMPLICOR Monitor Test for Determination of Hepatitis B Virus DNA Levels, Journal of Clinical Microbiology. 2004, 42: 3513-3517.

Yuan H., Yuen R.M.F., Wong D.K.H., Sum S.M., Doutreloigne J., Sablon E. and Lai C.L., Determinants for the Occurrence of Acute Exacerbation of Hepatitis B Virus Infection in Chinese Patients after HBeAg Seroclearance , Journal of Clinical Microbiology. 2005, 43: 1594-1599.

Yuen M.F., Ng I.O.L., Fan S.T., Yuan H., Wong D.K.H., Yuen J.C.H., Sum S.M., Chan O.O. and Lai C.L., Significance of HBV DNA levels in liver histology of HBeAg and anti-HBe positive patients with chronic hepatitis B, American Journal of Gastroenterology. 2004, 99(10): 2032-2037.

Yuen R.M.F., Lim W.L., Chan O.O., Wong D.K.H., Sum S.M. and Lai C.L., 18-year follow-up study of a prospective randomized trial of hepatitis B vaccinations without booster doses in children, Clinical Gastroenterology and Hepatology. 2004, 2(10): 941-5.

Yuen R.M.F., Wong D.K.H., Sum S.M., Yuan H., Yuen J.C.H., Chan O.O., Wong B.C.Y. and Lai C.L., Effect of lamivudine therapy on the serum covalently closed circular DNA of chronic hepatitis B infection., 55th Annual Meeting of the American Association for the Study of Liver Diseases, Boston, USA 29 Oct-2 Nov 2004 (Published in Hepatology). 2004, 40(4): 671A.

Yuen R.M.F., Wong D.K.H., Sum S.M., Yuan H., Yuen J.C.H., Chan O.O., Wong B.C.Y. and Lai C.L., Effect of lamivudine therapy on the serum covalently closed-circular (ccc) DNA of chronic hepatitis B infection., American Journal of Gastroenterology. 2005, 100(5): 1099-103.

Yuen R.M.F., Sablon E., Tanaka Y., Kato T., Mizokami M., Doutreloigne J., Yuan H., Sum S.M. and Lai C.L., Epidemiological study of hepatitis B virus genotypes, core promoter and precore mutations of chronic hepatitis B infection in Hong Kong. , Journal of hepatology : the journal of the European Association for the Study of the Liver. 2004, 41(1): 119-25.

Yuen R.M.F., Wong D.K.H., Yuan H., Sum S.M. and Lai C.L., HBsAg seroclearance in Chinese patients receiving lamivudine therapy for chronic hepatitis B virus infection, Journal of Clinical Microbiology. 2004, 42(10): 4882-4.

Yuen R.M.F., Fung S.K., Tanaka Y., Kato T., Mizokami M., Yuen J.C.H., Wong D.K.H., Yuan H., Sum S.M., Chan O.O., Wong B.C.Y. and Lai C.L., Longitudinal study of hepatitis activity and viral replication before and after HBeAg seroconversion in chronic hepatitis B patients infected with genotypes B and C., Journal of Clinical Microbiology. 2004, 42(11): 5036-40.

Yuen R.M.F., Tanaka K., Mizokami M., Yuen J.C.H., Hui C.K., Wong D.K.H., Yuan H., Sum S.M., Chan O.O., Wong B.C.Y., Fan S.T. and Lai C.L., Role of hepatitis B virus genotypes Ba and C, core promoter and precore mutations on hepatocellular carcinoma: a case control study, Carcinogenesis. 2004, 25(9): 1593-1598.

Researcher : Sun H

List of Research Outputs

Deng X., Sun H., Lau C.P. and Li G.R., Protein Tyrosine Kinase Modulates Voltage-gated Delayed Rectifier Potassium Channels In Rat Mesenchymal Stem Cells From Bone Marrow, Journal of Hong Kong College Cardiology. 2004, 12: 101(P12).

Gao Z., Sun H., Chiu S.W., Lau C.P. and Li G.R., Effects Of Diltiazem And Nifedipine On Transient Outward And Ultra-rapid Delayed Rectifier Potassium Currents In Human Atrial Myocytes, Br J Pharmacol. 2005, 144: 495-604.

Li G.R., Sun H., Deng X. and Lau C.P., Characterization of ionic currents in human mesenchymal stem cells from bone marrow, Stem Cells. 2005, 23: 371-382.

Li G.R., Deng X., Sun H. and Lau C.P., Ion Channels And Cell Proliferation In Mesenchymal Stem Cells From Rat Bone Marrow, Biophysical Journal . 2005, 88(2/2): 547a.

Researcher : Sun JZ

List of Research Outputs

Hui C.K., Lie A.K.W., Au W.Y., Ma S.Y., Leung A.Y.H., Zhang H., Sun J.Z., Cheung W.W.W., Chim J.C.S., Kwong Y.L., Liang R.H.S. and Lau G., Effectiveness of prophylactic Anti-HBV therapy in allogeneic hematopoietic stem cell transplantation with HBsAg positive donors, American Journal of Transplantation. 2005, 5(6): 1437-45.

Kwok P.W., Leung Y.H., Sun J.Z., Yan C.P.K., Ooi C.G.C., Ho P.L., Ho J.C.M., Tipoe G.L., Lam W.K. and Tsang K.W.T., The Effects of Gelomyrtol Forte on Human Ciliary Beat Frequency in vitro, Abstract Book of the 10th Medical Research Conference, University Department of Medicine, The University of Hong Kong, 19-20 February. 2005, page 65.

Kwok R., Leung Y.H., Sun J.Z., Yan C.P.K., Ooi C.G.C., Ho P.L., Ho J.C.M., Tipoe G.L., Lam W.K. and Tsang K.W.T., The effects of gelomyrtol forte on human ciliary beat frequency in vitro, Respirology. 2004, 9 (Suppl): A162 (290).

Tsang K.W.T., Tipoe G.L., Mak J.C.W., Sun J.Z., Wong M.P., Leung R.C.M., Tan K.C.B., MedStat C.K.M., Ho J.C.M., Ho P.L., Rutman A. and Lam W.K., Ciliary central microtubular orientation is of no clinical significance in bronchiectasis, Respiratory Medicine. 2005, 99: 290-297.

Tsang K.W.T., Tipoe G.L., Sun J.Z., Tan K.C.B., Leung Y.H., Yan C.P.K., Ko K.W., Ooi C.G.C., Ho J.C.M. and Lam W.K., Clinical value of ciliary assessment in bronchiectasis, Lung. 2005, 183(2): 73-86.

Researcher : Sun Y

List of Research Outputs

Chan O.O., Chu K.M., Sun Y., Cheung K.L., Lam S.K., Yuen R.M.F., Hui W.M. and Wong B.C.Y., The association between Interleukin 1 beta polymorphism and hypermethylation at tumor suppressor genes in gastric cancer. Conference paper at the Annual Meeting of the American Gastroenterology Associatoin, Digestive Diseases Week (DDW) Chicago, Illinois, USA. May 14-19, Gastroenterology. 2005, 128(4 Suppl 2): A399.

Zhu S., Xia H.H.X., Lam S.K., Yu L., Yang Y., Sun Y., Wang J., Chan O.O. and Wong B.C.Y., Alterations of gastric homeoprotein expression in H. Pylori infection and/or intestinal metaplasia, Gastroenterology. 2005, 128(4 Suppl 2): A598.

Researcher : Tam S

List of Research Outputs

Gu J., Lee K.K., Kwan E.Y.W., Lam K.F., Ho A.Y.Y., Tam S. and Kung A.W.C., Determinants of bone mineral density in Asian men, 26th Annual Meeting of the American Society for Bone & Mineral Research, October 1-5, 2004, Seattle, USA. Journal of Bone and Mineral Research. 2004, 19(Supl 1): SU115.

Gu J., Lee K.K., Cheung E.Y.N., Lam K.F., Ho A.Y.Y., Tam S. and Kung A.W.C., Determinants of bone mineral density in Asian men, HKU 10th Medical Research Conference. 2005.

Lam K.S.L., Xu A., Tan K.C.B., Wong L.C., Tiu S.C. and Tam S., Serum adiponectin is reduced in acromegaly and normalized after correction of growth hormone excess, Journal of Clinical and Endocrinological Metabablism. 2004, 89(11): 5448-53.

Mak C.M., Lam K.S.L., Ma O.C., Tso A.W. and Tam S., Novel insertion 496_497insG creating a stop codon D194X in Chinese family with X-Linked adrenoleukodystrophy, Horm Res.. 2005, 63(1): 1-5.

Tan K.C.B., Tso A.W.K., Ma O.C., Pang W.C., Tam S. and Lam K.S.L., Determinants of postprandial triglyceride and remnant-like lipoproteins in type 2 diabetes, Diabetes Metabolism Research and Reviews. 2005, 21(2): 209-14.

Tan K.C.B., Chow W.S., Lam J.C.M., Lam B., Wong W.K., Tam S. and Ip M.S.M., HDL dysfunction in obstructive sleep apnea, Atherosclerosis. 2005-02-01, 2005, Epub ahead of print.

Tan K.C.B., Xu A., Chow W.S., Ai W.H.G., Tam S. and Lam K.S.L., Hypoadiponectinemia is associated with impaired endothelium-dependent vasodilatation, Journal of Clinical and Endocrinological Metabolism. 2004, 89(2): 765-9.

Tan K.C.B., Shiu S.W.M., Wong Y. and Tam S., Plasma phospholipid transfer protein activity and subclinical inflammation in type 2 diabetes mellitus, Atherosclerosis. 2005, 178(2): 365-70.

Wong B.C.Y., Chan O.O., Wong K.W., Ching C.K., Wong R.W.M., Tam S., Lai K.C., Chan C.K., Yuen R.M.F. and Lam S.K., A pilot study of participation in faecal occult blood testing and screening colonoscopy after health education in Hong Kong, European Journal of Cancer Preview. 2005, 14(2): 181-184.

Researcher : Tan KCB

Project Title:	Roles of oxidative stress in inflammation and lipid peroxidation in obstructive sleep apnoea
Investigator(s):	Tan KCB, Ip MSM, Chow W.S., Lam B.
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002
Completion Date:	09/2004

Abstract:

To investigate whether oxidative stress induces inflammation and lipid peroxidation in patients with OSA and to determine whether these abnormalities can be reversed by reducing leucocyte oxidative stress using continuous positive airway pressure (CPAP) therapy.

Project Title:	Advanced glycation end products and diabetic complications
Investigator(s):	Tan KCB, Betteridge J.
Department:	Medicine
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	12/2002

Abstract:

Hyperglycaemia leading to the increased formation and accumulation of advanced glycation end products (AGEs) has been implicated in causing many of the complications of diabetes. In this project, the research team plan to explore the underlying mechanisms whereby AGEs may cause defective endothelium-dependent vasodilation.

Project Title:	Effects of adiponectin on endothelial cell function
Investigator(s):	Tan KCB, Lam KSL, Xu A
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Abstract:

To investigate whether adiponectin increases NO production by inducing eNOS expression and activity; to determine whether adiponectin phosphorylates eNOS through Akt activation.

Project Title:	Reverse cholesterol transport in diabetes
Investigator(s):	Tan KCB
Department:	Medicine
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2004

Abstract:

Refer to hard copy

Project Title:	Endothelial lipase activity in diabetes
Investigator(s):	Tan KCB
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Abstract:

To determine whether the expression of EL is increased in diabetes; to investigate the regulation of EL in vitro.

List of Research Outputs

Chan K.W., Xu A., Hoo R.L.C., Tan K.C.B., Zhang J., Lam C.W. and Lam K.S.L., Selective Reduction of the High Molecular Weight Form of Adiponectin by Testosterone: A Potential Mechanism That Underlies the Sexual Dimorphism of Adiponectin Oligomeric Distribution, The Endocrine Society’s 87th Annual Meeting, June 4-7, 2005, San Diego, USA. 2005.

Lam K.S.L. and Tan K.C.B., Adiponectin: protection of the endothelium, Curr Diab Rep. 2005, 5: 254-9.

Lam K.S.L., Xu A., Tan K.C.B., Wang Y., Dan Q., Chung S.K. and Chung S.S.M., Inflammation and diabetic atherosclerosis: New players in the field, Int Atherosclerosis Society 2005 Commentaries (Epub). 2005.

Lam K.S.L., Xu A., Tan K.C.B., Wong L.C., Tiu S.C. and Tam S., Serum adiponectin is reduced in acromegaly and normalized after correction of growth hormone excess, Journal of Clinical and Endocrinological Metabablism. 2004, 89(11): 5448-53.

Lam M.C., Tan K.C.B. and Lam K.S.L., Glycoxidized low-density lipoprotein regulates the expression of scavenger receptors in THP-1 macrophages, Atherosclerosis. 2004, 177(2): 313-20.

Tan K.C.B., Better Diabetes Control with Insulin, University Health Service Continuous Medical Education, Hong Kong, May 2005. 2005.

Tan K.C.B., Cholesterol, Fat and Diabetes, 2nd Trevor Berry Lecture, Diabetes Hongkong, Hong Kong, Oct 2004.. 2004.

Tan K.C.B., Common Endocrine problems, Update on Endocrinology and Targets for Lipid Therapy for the Hong Kong College of Family Physicians, Hong Kong, Sept 2004. 2004.

Tan K.C.B., Tso A.W.K., Ma O.C., Pang W.C., Tam S. and Lam K.S.L., Determinants of postprandial triglyceride and remnant-like lipoproteins in type 2 diabetes, Diabetes Metabolism Research and Reviews. 2005, 21(2): 209-14.

Tan K.C.B., Glycation and oxidation in age-related diseases, Frontiers in Biomedical Research, Hong Kong, Dec 2004. 2004.

Tan K.C.B., Chow W.S., Lam J.C.M., Lam B., Wong W.K., Tam S. and Ip M.S.M., HDL dysfunction in obstructive sleep apnea, Atherosclerosis. 2005-02-01, 2005, Epub ahead of print.

Tan K.C.B., Honorary Editorial Advisory Board Member, MIMS Endocrinology Guide. 2004.

Tan K.C.B., Hypertension management in diabetic patients, CME Meeting for Physicians, St Teresa’s Hospital, Hong Kong, June 2005. 2005.

Tan K.C.B., Xu A., Chow W.S., Ai W.H.G., Tam S. and Lam K.S.L., Hypoadiponectinemia is associated with impaired endothelium-dependent vasodilatation, Journal of Clinical and Endocrinological Metabolism. 2004, 89(2): 765-9.

Tan K.C.B., Member , Scientific Committee of the Global Conference on Cardiovascular Clinical Trials and Pharmacotherapy, October 2004, Hong Kong. 2004.

Tan K.C.B., Shiu S.W.M., Wong Y. and Tam S., Plasma phospholipid transfer protein activity and subclinical inflammation in type 2 diabetes mellitus, Atherosclerosis. 2005, 178(2): 365-70.

Tan K.C.B., Update in Lipid Management, Continuous Medical Education in Internal Medicine 2004/2005 , Macau, May 2005. 2005.

Tan K.C.B., Updates in the Management of Hypertension in Diabetes, Macau Diabetes Association, Macau, Nov 2004. 2004.

Tsang K.W.T., Tipoe G.L., Mak J.C.W., Sun J.Z., Wong M.P., Leung R.C.M., Tan K.C.B., MedStat C.K.M., Ho J.C.M., Ho P.L., Rutman A. and Lam W.K., Ciliary central microtubular orientation is of no clinical significance in bronchiectasis, Respiratory Medicine. 2005, 99: 290-297.

Tsang K.W.T., Tipoe G.L., Sun J.Z., Tan K.C.B., Leung Y.H., Yan C.P.K., Ko K.W., Ooi C.G.C., Ho J.C.M. and Lam W.K., Clinical value of ciliary assessment in bronchiectasis, Lung. 2005, 183(2): 73-86.

Tsang K.W.T., Tan K.C.B., Ho P.L., Ooi C.G.C., Khong P.L., Leung Y.H., Mak J.C.W., Tipoe G.L., Ko K.W. and Lam W.K., Exhaled nitric oxide in bronchiectasis: the effects of inhaled corticosteroid therapy, International Journal of Tuberculosis and Lung Disease. 2004, 8(11): 1301-1307.

Tsang K.W.T., Tan K.C.B., Ho P.L., Ooi C.G.C., Ho J.C., Mak J.C.W., Tipoe G.L., Ko C., Yan C. and Lam W.K., Inhaled fluticasone in bronchiectasis: a 12 month study, Thorax. 2005, 60: 239-243.

Xu A., Chan K.W., Hoo R.L.C., Wang Y., Tan K.C.B., Zhang J.C.L., Chen B., Lam M.C., Tse C., Cooper G.J. and Lam K.S.L., Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes, J Biol Chem. 2005, 280(18): 18073-80.

Researcher : Tang CSO

List of Research Outputs

Chan D.T.M., Tse K.C., Tang C.S.O., Lai K.N. and Li F.K., Long-term outcome of patients with diffuse proliferative lupus nephritis treated with prednisolone and oral cyclophosphamide followed by azathioprine. , Lupus. 2005, 14(4): 265-272.

Chan D.T.M., Tse K.C., Tang C.S.O., Mok T.M.Y., Li F.K. and Hong Kong Nephrology Study G.R.O.U.P., Long-term study of mycophenolate mofetil as continuous induction and maintenance treatment for diffuse proliferative lupus nephritis, Journal of American Society of Nephrology. 2005, 16(4): 1076-1084.

Chan D.T.M., Tse K.C., Tang C.S.O., Lai K.N. and Ho S.K.N., Prospective study on lamivudine-resistant hepatitis B in renal allograft recipients, American Journal of Transplantation. 2004, 4(7): 1103-1109.

Chu K.H., Tsang W.K., Tang C.S.O., Lam M.F., Lai F.M., To K.F., Fung K.S., Tang H.L., Yan W.W., Chan H.W.H., Lai T.S.T., Tong K.L. and Lai K.N., Acute renal impairment in coronavirus-associated severe acute respiratory syndrome, Kidney International. 2005, 67: 698-705.

Lo W.K., Lui S.L., Chan D.T.M., Li F.K., Lam M.F., Tse K.C., Tang C.S.O., Choy C.B.Y. and Lai K.N., Minimal and optimal peritoneal Kt/V targets: results of an anuric peritoneal dialysis patient's survival analysis. , Kidney International. 2005, 67(5): 2032-2038.

Researcher : Tang CW

Project Title:	Regulation of albumin-induced chemokine expression in human proximal tubular epithelial cells by angiotensin antagonists and HMG-CoA reductase inhibitors
Investigator(s):	Tang SCW
Department:	Medicine
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	01/2005

Abstract:

To explore in vitro the effect of ACEI, ARB, and statins, either singly or in combination, on albumin-induced expression of IL-8, MCP-1 RANTES, and MIF incultured human PTEC; to dissect the intracellular signal transduction pathway governing the anti-inflammatory effects of these pharmacological agents; to investigate the I>in vitro impact of applying combined a ngiotensin II b blockade and statin treatment on enphrotic mice.

Project Title:	Regulation of albumin-induced chemokine expression in human proximal tubular epithelial cells by angiotensin antagonists and HMG-CoA reductase inhibitors
Investigator(s):	Tang SCW
Department:	Medicine
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

Refer to hard copy

List of Research Outputs

Researcher : Tang MO

List of Research Outputs

Tse H.F., Siu C.W., Lee K.L.F., Tang M.O., Tsang V.Y.C., Chan H.W. and Lau C.P., Incremental benefit of rate adaptive pacing onexercise performance during cardiac resynchronization therapy., Heart Rhythm. 2005, 2: S166.

Researcher : Tang S

List of Research Outputs

Lui S.L., Tang S., Li F.K., Choy C.B.Y., Chan D.T.M., Lo W.K. and Lai K.N., Tuberculous infection in southern Chinese renal transplant recipients, Clinical transplantation. 2004, 18(6): 666-671.

Researcher : Tang SCW

Project Title:	Regulation of albumin-induced chemokine expression in human proximal tubular epithelial cells by angiotensin antagonists and HMG-CoA reductase inhibitors
Investigator(s):	Tang SCW
Department:	Medicine
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	01/2005

Abstract:

Project Title:	Regulation of albumin-induced chemokine expression in human proximal tubular epithelial cells by angiotensin antagonists and HMG-CoA reductase inhibitors
Investigator(s):	Tang SCW
Department:	Medicine
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

Refer to hard copy

List of Research Outputs

Chan L.Y., Leung J.C.K., Tsang W.L., Tang S.C.W. and Lai K.N., Activation of tubular epithelial cells by mesangial-derived TNF-alpha: glomerulotubular communication in IgA nephropathy , Kidney International. 2005, 67: 602-612.

Lai K.N., Leung J.C.K., Chan L.Y., Li F.K., Tang S.C.W., Lam M.F., Tse K.C., Yip T., Chan D.T.M., Wieslander A. and Vlassara H., Differential expression of receptors for advanced glycation end-products in peritoneal mesothelial cells exposed to glucose degradation products, Clinical and Experimental Immunology. 2004, 138: 466-475.

Lai K.N., Chan L.Y., Tsang W.L., Tang S.C.W. and Leung J.C.K., Differential regulation of AT1 and AT2 receptors by angiotensin II in human mesangial and renal proximal tubular epithelial cells, Journal of American Society of Nephrology. 2004, 15: 841A.

Lai K.N., Chan L.Y., Tang S.C.W., Tsang W.L., Li F.K., Lam M.F., Lui S.L. and Leung J.C.K., Mesangial expression of angiotensin II receptor in IgA nephropathy and its regulation by polymeric IgA1 , Kidney International. 2004, 66: 1403-1416.

Lai K.N., Mok C.C. and Tang S.C.W., Treatment for lupus nephritis: a revisit , Nephrology. 2005, 10: 180-188.

Lai K.N., Tang S.C.W., Tsang W.L., Chan L.Y. and Leung J.C.K., Ganaderma extract prevents albumin-induced oxidative damage and chemokine synthesis in cultured human proximal tubular epithelial cells, Journal of American Society of Nephrology. 2004, 15: 107A.

Leung J.C.K., Chan L.Y., Tsang W.L., Tang S.C.W. and Lai K.N., Anti-macrophage migration inhibitory factor reduces transforming growth factor-beta 1 expression in experimental IgA nephropathy, Nephrology Dialysis Transplantation. 2004, 19: 1976-1985.

Leung J.C.K., Chan L.Y., Tsang W.L., Guo H., Tang S.C.W., Chan D.T.M. and Lai K.N., Differential expression of aquaporins in the kidneys of streptozotocin-induced diabetic mice , Nephrology. 2005, 10: 63-72.

Leung J.C.K., Chan Y.Y., Li F.K., Tang S.C.W., Chan K.W., Chan D.T.M., Lam M.F., Wieslander A. and Lai K.N., Glucose degradation products downregulate ZO-1 expression in human peritoneal mesothelial cells: the role of VEGF, Nephrology Dialysis Transplantation. 2005, 20(7): 1336-1349.

Leung J.C.K., Chan L.Y., Tsang W.L., Tang S.C.W. and Lai K.N., Increased synthesis of TNF-a and IL-6 by mesangial cells cultured with polymeric anionic IgA from patients with IgA nephropathy, Journal of American Society of Nephrology. 2004, 15: 224A.

Li P.K., Weening J.J., Dirks J., Lui S.L., Szeto C.C., Tang S.C.W., Atkins R.C., Mitch W.E., Chow K.M., D'Amico G., Freedman B.I., Harris D.C., Hooi L.S., Jong P.E., Kincaid-Smith P. and Lai K.N., A report with consensus statements of the International Society of Nephrology 2004 Consensus Workshop on Prevention of Progression of Renal Disease, Hong Kong, June 29, 2004 , Kidney International. 2005, 67(suppl 94): S2-S7.

Mok C.C., Ying K.Y., Tang S.C.W., Leung C.Y., Lee K.W., Ng W.L., Wong R.W.S. and Lau W.C.S., Predictors and outcome of renal flares after successful cyclophosphamide treatment for diffuse proliferative lupus glomerulonephritis. , Arthritis & Rheumatism. 2004, 50: 2559-2568.

Tang S.C.W., Leung J.C.K., Chan L.Y., Tsang W.L. and Lai K.N., Albumin-induced interleukin-8 expression in renal tubular cells is abrogated by angiotensin type 2 but not type 1 receptor blockade, Journal of American Society of Nephrology. 2004, 15: 847A.

Tang S.C.W., Tse K.C., Chan K.W., Ho Y.W. and Lai K.N., Anderson-Fabry disease, American Journal of Kidney Diseases. 2005, 45: A51, e21-22.

Tang S.C.W. and Lai K.N., Chronic viral hepatitis in hemodialysis patients, Hemodialysis Internatoinal. 2005, 9: 169-179.

Tang S.C.W., Ho Y.W., Leung V.K., Leung C.Y., Chan D.T.M. and Lai K.N., Lamivudine improves renal outcome in hepatitis-B related membranous nephropathy, Journal of American Society of Nephrology. 2004, 15: 341A.

Tang S.C.W., Ho Y.W., Tang A., Cheng A., Lam W.N. and Lai K.N., Late initiation of dialysis adversely affects short-term outcome in peritoneal dialysis subjects, Nephrology. 2005, 10(suppl): A76.

Tang S.C.W., Lui S.L. and Lai K.N., Pathogenesis of lupus nephritis: an update , Nephrology. 2005, 10: 174-179.

Tang S.C.W. and Lai K.N., Posttransplantation lymphoproliferative disorder (PTLD) involving the brain and the allograft, American Journal of Kidney Diseases. 2005, 45: A55, e61-2.

Tang S.C.W., Screening and Prevention of Chronic Kidney Disease: What Can We Do? , 9th Hong Kong Medical Forum. 2004.

Tang S.C.W., Leung W.S., Chan V., Chu C.M., Lam B., Leung H., Lam W.O., Ho Y.W., Chan D.T.M. and Lai K.N., Sleep apnea in patients undergoing nocturnal peritoneal dialysis., Peritoneal Dialysis International. 2004, 24 (S2): S49.

Tang S.C.W. and Lai K.N., Ultrasound-guided biopsy of native and transplanted kidneys., Saudi Journal of Kideny Diseases and Transplantation. 2004, 15: 300-304.

Researcher : Tian M

List of Research Outputs

Tian M., Dong M., Chiu S.W., Lau C.P. and Li G.R., Effects Of Clotrimazole On Human Cardiac Repolarization Potassium Currents, Journal of Hong Kong College Cardiology. 2004, 12(3/4): 101(P11).

Researcher : Tiu SC

List of Research Outputs

Lam K.S.L., Xu A., Tan K.C.B., Wong L.C., Tiu S.C. and Tam S., Serum adiponectin is reduced in acromegaly and normalized after correction of growth hormone excess, Journal of Clinical and Endocrinological Metabablism. 2004, 89(11): 5448-53.

Xu J., Dan Q., Chan V.N.Y., Wat N.M.S., Tam S., Tiu S.C., Lee K.F., Siu S.C., Tsang M.W., Fung L.M., Chan K.W. and Lam K.S.L., Genetic and Clinical Characteristics of Maturity-onset Diabetes of the Young in Chinese Patients, European Journal of Human Genetics. 2005, 13: 422-427.

Researcher : Tong SM

List of Research Outputs

Wong R.W.M., Huang J., Xia H.H.X., Fung F.M.Y., Tong S.M., Cheung K.L., Ho Y.K., Lai K.C., Chan C.K., Chan O.O., Hui C.K., Lam S.K. and Wong B.C.Y., Low-dose rabeprazole, amoxicillin and metronidazole triple therapy for the treatment of Helicobacter pylori infection in Chinese patients , Journal of Gastroenterology and Hepatology. 2005, 20(6): 935-940.

Researcher : Tsang KWT

Project Title:	Could gastro-oesphageal reflux be a cause of continued airway damage in bronchiectasis?
Investigator(s):	Tsang KWT, Hu W.
Department:	Medicine
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	11/2002

Abstract:

The study is to determine the prevalence and severity of gastro-oesophageal reflux (GOR) in patients with bronchiectasis, the relationship of GOR with airway inflammation parameters, and identify clinical an dother parameters which predict the presence of GOR in patients with bronchiectasis with and without upper abdominal symptoms.

Project Title:	Are matrix metalloproteinases (MMP-8, MMP-9) responsible for the continued destruction and perpetuation of inflammation in the airways of bronchiectasis?
Investigator(s):	Tsang KWT, Mak JCW, Tipoe GL
Department:	Medicine
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2003

Abstract:

To evaluate the hypothesis, based on our preliminary findings, that airway matrix metalloproteinase (MMP)-8 and -9, released by airway neutrophils, significantly contribute to the development of continued inflammation and tissue destruction in bronchiectasis; to study the in vitro effects of these MMPs on the functional, ultrastructural and immunological aspects of airway mucosa; to assess the in vitro efficacy of various potential novel therapeutic and chemical agents on the effects of these MMPs.

List of Research Outputs

Chan M.M.W., Tan-Un K.C., Ip M.S.M., Tsang K.W.T., Ho S.P., Ho J.C.M., Chan H. and Lam W.K., Lung Cancer Susceptibility and Polymorphism of Glutathione-S-transferase Genes in Hong Kong, Lung Cancer. 2004, 45(2): 155-160.

Chan M.M.W., Lam W.K., Mak J.C.W., Ho S.P., Chan H.W., Tsang K.W.T., Ip M.S.M., Ho J.C.M., Wong M.P. and Tan-Un K., Polymorphisms of CYP and GST genes, passive smoke and lung cancer risk in Hong Kong Chinese, European Respiratory Journal. 2004, 24: Suppl 48: 457s.

Cheung B.M.Y., Hwang I.S.S., Li C., Tsang K.W.T., Leung Y.H., Kumana C.R. and Tang F., Increased Adrenomedullin Expression in Lungs in Endotoxaemia, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong. 2004.

File T.M. .J.R. and Tsang K.W.T., Severe acute respiratory syndrome: pertinent clinical characteristics and therapy, Treat Respiratory Medicine. 2005, 4(2): 95-106.

Ho J.C.M., Lam W.K., Wong M.P., Wong M.K., Ooi C.G.C., Ip M.S.M., Chan M.M.W. and Tsang K.W.T., Lymphoepithelioma-like carcinoma of the lung : experience with ten cases, International Journal of Tuberculosis and Lung Disease. 2004, 8(7): 890-895.

Ho J.C.M., Mak J.C.W., Ho S.P., Ip M.S.M., Tsang K.W.T., Lam W.K. and Chan M.M.W., Manganese superoxide dismutase and catalase genetic polymorphisms activity levels and lung cancer risk in Chinese in Hong Kong, 10th Medical Research Conference, Department of Medicine, The University of Hong Kong, February 2005. Abstract Book: RM 66.

Ho J.C.M., Ho S.P., Chan M.M.W., Mak J.C.W., Ip M.S.M., Ko K.W., Yan C.P.K., Wong M.P., Tsang K.W.T. and Lam W.K., Non-small cell lung cancer in Chinese is associated with disturbance in systemic antioxidant profiles, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December, 2004. Respirology. 2004, 9 (Supp): A114.

Ho J.C.M., Wu A.Y.Y., Lam B., Ooi C.G.C., Khong P.L., Ho P.L., Chan M.M.W., Zhong N.S., Ko K.W., Lam W.K. and Tsang K.W.T., Pentaglobin in steroid-resistant severe acute respiratory syndrome, International Journal of Tuberculosis and Lung Disease. 2004, 8(10): 1173-1179.

Ho P.L., Chow K.H., Mak G.C., Tsang K.W.T., Lau Y.L., Ho A.Y., Lai E.L. and Chiu S.S.S., Decreased Levofloxacin Susceptibility in Haemophilus influenzae in Children, Hong Kong, Emerging Infectious Diseases. 2004, 10(11): 1960-1962.

Ho P.L., Shek R.H., Chow K.H., Duan R., Mak C.K., Lai E.L.Y., Yam W.C., Tsang K.W.T. and Lai W.M., Detection and characterization of extended-spectrum beta-lactamases among bloodstream isolates of Enterobacter spp. in Hong Kong, 2000-2002., Jouranl of Antimicrobial Chemotherapy. 2005, 55(3): 326-32.

Ho S.P., Chan M.M.W., Wong M.P., Tsang K.W.T., Ip M.S.M., Lam W.K. and Mak J.C.W., Transforming growth factor (TGF)-beta 1 gene common polymorphisms and plasma TGF-beta 1 levels in patients with lung cancer, 10th Medical Research Conference, Department of Medicine, The University of Hong Kong, February 2005. Abstract Book: RM 60.

Ho S.P., Chan M.M.W., Tsang K.W.T., Ip M.S.M., Lam W.K. and Mak J.C.W., Transforming growth factor (TGF)-beta 1 gene common polymorphisms and plasma TGF-beta 1 levels in patients with lung cancer, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A120.

Ip S.K., Tsang K.W.T. and Lam W.K., Idiopathic Pulmonary Fibrosis in Hong Kong SAR , Abstract Book of the 10th Medical Research Conference, University Department of Medicine, The Univeristy of Hong Kong, 19-20 February. 2005, page 63.

Ip S.K., Tsang K.W.T. and Lam W.K., Idiopathic pulmonary fibrosis in Hong Kong SAR, Respirology. 2004, 9 (suppl): A111 (274).

Kwok P.W., Leung Y.H., Sun J.Z., Yan C.P.K., Ooi C.G.C., Ho P.L., Ho J.C.M., Tipoe G.L., Lam W.K. and Tsang K.W.T., The Effects of Gelomyrtol Forte on Human Ciliary Beat Frequency in vitro, Abstract Book of the 10th Medical Research Conference, University Department of Medicine, The University of Hong Kong, 19-20 February. 2005, page 65.

Kwok R., Leung Y.H., Sun J.Z., Yan C.P.K., Ooi C.G.C., Ho P.L., Ho J.C.M., Tipoe G.L., Lam W.K. and Tsang K.W.T., The effects of gelomyrtol forte on human ciliary beat frequency in vitro, Respirology. 2004, 9 (Suppl): A162 (290).

Lam J.C.M., Ooi C.G.C., Lam K.S.L., Tam S., Lai A.Y.K., Tsang K.W.T., Lam W.K. and Ip M.S.M., The relationship of insulin resistance, obesity and sleep-disordered breathing , 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology . 2004, 9 (Supp): A143.

Lam J.C.M., Ooi C.G.C., Lam K.S.L., Tam S., Lai A.Y.K., Tsang K.W.T., Lam W.K. and Ip M.S.M., The relationship of insulin resistance, obesity and sleep-disordered breathing, 10th Medical Research Conference, Department of Medicine, The University of Hong Kong, February 2005. Abstract Book: RM 59.

Lam W.K., Tsang K.W.T., Ooi C.G.C., Ip M.S.M. and Chan M.M.W., Infections: Severe Acute Respiratory Syndrome., In: Ip M, Chan-Yeung M, Lam WK, Zhong NS, Respiratory Medicine, An Asian Perspective. Hong Kong, Hong Kong University Press, 2004, 307-323.

Lam W.K., Ho J.C.M., Lam B. and Tsang K.W.T., SARS and impacts on travel, Textbook of Travel Medicine . Bangkok Press, Bangkok, 2004, Chapter 38: 405-414.

Lam W.K., Tsang K.W.T., Ooi C.G.C., Ip M.S.M. and Chan M.M.W., Severe Acute Respiratory Syndrome. In: Ed. Ip MSM, Chan MMW, Lam WK, Zhong NS, Respiratory Medicine - An Asian Perspective. Hong Kong University Press, 2005, Chapter 18: pp. 307-323.

Mak J.C.W., Ho S.P., Leung Y.H., Ho P.L., Ooi C.G.C., Yan C.P.K., Ko K.W., Ip M.S.M., Lam W.K. and Tsang K.W.T., Elevated levels of transforming growth factor- beta 1 in serum of patients with stable bronchiectasis, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A134.

Mak J.C.W., Leung C.M., Ho S.P., Law K.W., Tsang K.W.T., Lam W.K., Ip M.S.M. and Chan M.M.W., Genetic susceptibility of transforming growth factor beta-1 common polymorphisms to Chinese patients with asthma, American Thoracic Society International Conference, San Diego, USA. May 2005. Proceedings of the American Thoracic Society. 2005, p.A78.

Mak J.C.W., Ho J.C.M., Ho S.P., Yu W.C., Yew W.W., Tsang K.W.T., Lam W.K., Ip M.S.M. and Chan M.M.W., Increased oxidative stress and altered antioxidant status in Chinese patients with COPD, European Respiratory Journal. 2004, 24: Suppl 48: 62s.

Mak J.C.W., Hui W.S., Johnson M.W., Barnes P.J. and Tsang K.W.T., Modulation of Functional Pulmonary β2-Adrenoceptor by Tansforming Growth Factor-β1 in Human Bronchial Epithelial Cells, Abstract Book of the 10th Medical Research Conference, University Department of Medicine, The University of Hong Kong, 19-20 Feb. 2005, page 61.

Mak J.C.W., Leung H.C., Ho S.P., Lam W.K., Tsang K.W.T., Ip M.S.M. and Chan M.M.W., Systemic antioxidant status in Chinese patients with asthma, European Respiratory Journal. 2004, 24: Suppl 48: 509s.

Mak J.C.W., Leung C.M., Ho S.P., Lam W.K., Tsang K.W.T., Ip M.S.M. and Chan M.M.W., Systemic oxidative and antioxidative status in Chinese patients with asthma, Journal of Allergy and Clinical Immunology. 2004, 114(2): 260-264.

Ooi C.G.C., Khong P.L., Wong M. and Tsang K.W.T., An analysis of acute and follow-up HRCT features in 23 cases of cryptogenic organizing pneumonia (COP)., 1st World Congress of Thoracic Imaging, Florence, Italy.. 2005.

Pan N.Y., Hui W.S., Tipoe G.L., Tsang K.W.T. and Mak J.C.W., Effects of Glucocorticosteroids and Antimicrobial Drugs on Inhibition of IL-1β- and PDBu-induced IL-8 Release in the Presence of Pyocyanin in Bronchial Epithelial Cell Line, Abstract Book of the 10th Medical Research Conference, University Department of Medicine, The University of Hong Kong, 19-20 February. 2005, page 62.

Pang C., Fan S., Yiu M.W.C., Tsang K.W.T., Ho J.C.M. and Ooi C.G.C., Clinical utility of multislice CT in the investigation of haemoptysis., 1st World Congress of Thoracic Imaging, Florence, Italy.. 2005.

Tsang K.W.T., AECB/COPD, International Conference on Health Sciences "Partnership in Healthcare: Lessons Learnt and Future Challenges", in conjunction with the University of Malaya Centennial Celebration, Kuala Lumpur, Malaysia, 6-8 May . 2005.

Tsang K.W.T., Ooi C.G.C. and Ip M.S.M., Airway Diseases : Bronchiectasis., In: Ip M, Chan-Yeung M, Lam WK, Zhong NS., Respiratory Medicine, An Asian Perspective.. Hong Kong, Hong Kong University Press, 2004, 43-59.

Tsang K.W.T., Assessment of dysphagia , At Nutrition symposium 2005 -"Sustaining Life by Feeding: Nutritional Aspects", Hong Kong, 20 April . 2005.

Tsang K.W.T., Bronchiectasis , “Respiratory Infections in Asia" symposium - 24th International Congress on Chemotherapy (ICC) in Manila, 4-6 June . 2005.

Tsang K.W.T., Bronchiectasis – What have we learnt?, 9th Congress of the Asian Pacific Society of Respirology, Hong Kong, 10–13 December . 2004.

Tsang K.W.T., Bronchiectasis – a poorly understood disease, Medical Research Conference of the University Department of Medicine, the University of Hong Kong, 19 February . 2005.

Tsang K.W.T., Ooi C.G.C. and Ip M.S.M., Bronchiectasis. In: Ed. Ip MSM, Chan MMW, Lam WK, Zhong NS , Respiratory Medicine - An Asian Perspective. Hong Kong University Press, 2005, pp. 43-59.

Tsang K.W.T., Tipoe G.L., Mak J.C.W., Sun J.Z., Wong M.P., Leung R.C.M., Tan K.C.B., MedStat C.K.M., Ho J.C.M., Ho P.L., Rutman A. and Lam W.K., Ciliary central microtubular orientation is of no clinical significance in bronchiectasis, Respiratory Medicine. 2005, 99: 290-297.

Tsang K.W.T., Tipoe G.L., Sun J.Z., Tan K.C.B., Leung Y.H., Yan C.P.K., Ko K.W., Ooi C.G.C., Ho J.C.M. and Lam W.K., Clinical value of ciliary assessment in bronchiectasis, Lung. 2005, 183(2): 73-86.

Tsang K.W.T., Ooi C.G.C. and Ho P.L., Diagnosis and pharmacotherapy of severe acute respiratory syndrome: what have we learnt?, European Respiratory Journal. 2004, 24(6): 1025-1032.

Tsang K.W.T., Tan K.C.B., Ho P.L., Ooi C.G.C., Khong P.L., Leung Y.H., Mak J.C.W., Tipoe G.L., Ko K.W. and Lam W.K., Exhaled nitric oxide in bronchiectasis: the effects of inhaled corticosteroid therapy, International Journal of Tuberculosis and Lung Disease. 2004, 8(11): 1301-1307.

Tsang K.W.T., Tan K.C.B., Ho P.L., Ooi C.G.C., Ho J.C., Mak J.C.W., Tipoe G.L., Ko C., Yan C. and Lam W.K., Inhaled fluticasone in bronchiectasis: a 12 month study, Thorax. 2005, 60: 239-243.

Tsang K.W.T., Lung Cancer Treatment Update, At "Baptist Hospital CME (Physicians) Programmme", Hong Kong, 6 June . 2005.

Tsang K.W.T., Pathogenesis of bronchiectasis, the American Thoracic Society Annual Scientific Meeting, San Diego, USA, 25 May . 2005.

Tsang K.W.T., Prevention and Treatment of Influenza, To Advances In Therapeutics Course for British Medical Association (Hong Kong Branch) Hong Kong, 21February - 14 March . 2005.

Tsang K.W.T., Public Health Issues and Contingency Plans - Research Clinical Trials , At“Symposium on Avian Influenza – In Perparation for a Pandemic”,Hong Kong, 16 April . 2005.

Tsang K.W.T., SLE and The Lung, At Symposium on Systemic Lupus Erythematosus: Focus on Organ Involvement At the Macau Chinese Medical Association and the Macau Society of Nephrology Meeting, Macau, 27 February . 2005.

Tsang K.W.T., Treatment of bronchial infections – disease free period and other aspects, 9th Congress of the Asian Pacific Society of Respirology, Hong Kong, 10–13 December . 2004.

Tsang K.W.T., Update on COPD Management, At"Baptist Talk", Hong Kong Baptist Hospital, Hong Kong, 7 March . 2005.

Wong J.G.W.S., Cheung E.P.T., Cheung V., Cheung C., Chan M.T.Y., Chua S.E., McAlonan G.M., Tsang K.W.T. and Ip M.S.M., Psychological responses to the SARS outbreak in healthcare students in Hong Kong, Medical Teacher. Taylor & Francis health sciences, 2005, 26 (7): 657-663.

Wong M.K., Lam J.C., Ip S.K., Ip M.S.M., Lam W.K. and Tsang K.W.T., A comparative study on the efficacy of sequential intravenous and oral levofloxacin versus ceftazidime in treatment of infective exacerbation of bronchiectasis, 10th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2005, Abstract Book: RM 64.

Wong M.K., Lam J., Ip S., Lam C.L., Ip M.S.M., Lam W.K. and Tsang K.W.T., Quality of life effect of levofloxacin compared to ceftazidime treatment in infective exacerbation of bronchiectasis, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A135.

Researcher : Tsang MW

List of Research Outputs

Xu J., Dan Q., Chan V.N.Y., Wat N.M.S., Tam S., Tiu S.C., Lee K.F., Siu S.C., Tsang M.W., Fung L.M., Chan K.W. and Lam K.S.L., Genetic and Clinical Characteristics of Maturity-onset Diabetes of the Young in Chinese Patients, European Journal of Human Genetics. 2005, 13: 422-427.

Researcher : Tsang RCW

List of Research Outputs

Chan D.T.M., Tsang R.C.W., Tsang W.S. and Yung S.S.Y., Induction of Proximal Tubular Epithelial Cell Interleukin-6 Synthesis by Anti-DNA Antibodies Varies with the Activity of Lupus Nephritis, Journal of the American Society of Nephrology. 2004, 15: 684A.

Yung S.S.Y., Tsang R.C.W., Leung J.K.H. and Chan D.T.M., Anti-DNA antibodies from patients with lupus nephritis induce IL-6 expression in renal tubular epithelial cells, Nephrology. 2005, 10: A277.

Yung S.S.Y., Tsang R.C.W., Leung J.K.H. and Chan D.T.M., Induction of IL-6 by anti-DNA antibodies in proximal tubular epithelial cells varies with the activity of lupus nephritis, Lupus. 2005, 14: 237.

Yung S.S.Y., Tsang R.C.W., Leung J.K.H. and Chan D.T.M., Induction of IL-6 synthesis in proximal tubular epithelial cells by anti-DNA antibodies varies with lupus nephritis activity, 10th Medical Research Conference. 19-20 February 2005. Nephrology 45.

Researcher : Tsang VYC

List of Research Outputs

Sin P.Y., Tse H.F., Siu C.W., Tsang V.Y.C., Lam C.L.K. and Lau C.P., Impairment of quality-of-life in patients with atrial fibrillation. In Tse HF, Tse TF, Lau CP, Woo KS(eds), First Global Conference on Cardiovascular Clinical Trials and Pharmacotherapy - 2nd WHF Global Conference on Cardiovascular Clinical Trials and 13th International Society of Cardiovascular Pharmacotherapy Congress. Italy, Monduzzi Editore, 2005, 45-50.

Sin P.Y., Tse H.F., Siu C.W., Tsang V.Y.C., Lam C.L.K. and Lau C.P., Successful pulmonary vein isolation using transvenous catheter cryoablation improves quality-of-life in patients with atrial fibrillation. In Tse HF, Tse TF, Lau CP, Woo KS (eds):, First Global Conference on Cardiovascular Clinical Trials and Pharmacotherapy - 2nd WHF Global Conference on Cardiovascular Clinical Trials and 13th International Society of Cardiovascular Pharmacotherapy Congress. Italy, Monduzzi Editore, 2005, 51-56.

Tse H.F., Lau C.P., Tsang V.Y.C., Siu C.W., Yu C., Park E., Bornzin G.A. and Benser M.E., Blood pressure response to transition from supine to standing posture using an orthostatic response algorithm., Pacing Clin Electrophysiol. 2005, 28 Suppl 1: S242-5.

Tse H.F., Siu C.W., Lee K.L.F., Tang M.O., Tsang V.Y.C., Chan H.W. and Lau C.P., Incremental benefit of rate adaptive pacing onexercise performance during cardiac resynchronization therapy., Heart Rhythm. 2005, 2: S166.

Tse H.F., Tsang V.Y.C., Lam C.L.K., Lau C.P., Sin P.Y. and Siu C.W., Successful pulmonary vein isolation using transvenous catheter cryoablation improves quality-of-life in patients with atrial fibrillation, Pacing Clin Electrophysiol. 2005, 28(5): 421-4.

Researcher : Tsang WL

List of Research Outputs

Chan L.Y., Leung J.C.K., Tsang W.L., Tang S.C.W. and Lai K.N., Activation of tubular epithelial cells by mesangial-derived TNF-alpha: glomerulotubular communication in IgA nephropathy , Kidney International. 2005, 67: 602-612.

Lai K.N., Chan L.Y., Tsang W.L., Tang S.C.W. and Leung J.C.K., Differential regulation of AT1 and AT2 receptors by angiotensin II in human mesangial and renal proximal tubular epithelial cells, Journal of American Society of Nephrology. 2004, 15: 841A.

Lai K.N., Chan L.Y., Tang S.C.W., Tsang W.L., Li F.K., Lam M.F., Lui S.L. and Leung J.C.K., Mesangial expression of angiotensin II receptor in IgA nephropathy and its regulation by polymeric IgA1 , Kidney International. 2004, 66: 1403-1416.

Lai K.N., Tang S.C.W., Tsang W.L., Chan L.Y. and Leung J.C.K., Ganaderma extract prevents albumin-induced oxidative damage and chemokine synthesis in cultured human proximal tubular epithelial cells, Journal of American Society of Nephrology. 2004, 15: 107A.

Leung J.C.K., Chan L.Y., Tsang W.L., Tang S.C.W. and Lai K.N., Anti-macrophage migration inhibitory factor reduces transforming growth factor-beta 1 expression in experimental IgA nephropathy, Nephrology Dialysis Transplantation. 2004, 19: 1976-1985.

Leung J.C.K., Chan L.Y., Tsang W.L., Guo H., Tang S.C.W., Chan D.T.M. and Lai K.N., Differential expression of aquaporins in the kidneys of streptozotocin-induced diabetic mice , Nephrology. 2005, 10: 63-72.

Leung J.C.K., Chan L.Y., Tsang W.L., Tang S.C.W. and Lai K.N., Increased synthesis of TNF-a and IL-6 by mesangial cells cultured with polymeric anionic IgA from patients with IgA nephropathy, Journal of American Society of Nephrology. 2004, 15: 224A.

Tang S.C.W., Leung J.C.K., Chan L.Y., Tsang W.L. and Lai K.N., Albumin-induced interleukin-8 expression in renal tubular cells is abrogated by angiotensin type 2 but not type 1 receptor blockade, Journal of American Society of Nephrology. 2004, 15: 847A.

Researcher : Tsang WS

List of Research Outputs

Chan D.T.M., Tsang R.C.W., Tsang W.S. and Yung S.S.Y., Induction of Proximal Tubular Epithelial Cell Interleukin-6 Synthesis by Anti-DNA Antibodies Varies with the Activity of Lupus Nephritis, Journal of the American Society of Nephrology. 2004, 15: 684A.

Researcher : Tse EWC

Project Title:	Molecular mechanism of arsenic trioxide transport in acute promyelocytic leukaemia cells
Investigator(s):	Tse EWC, Kwong YL
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002
Completion Date:	10/2004

Abstract:

To investigate the mechanism underlying arsenic trioxide sensitivity in acute promyelocytic leukaemia (APL); to investigate the possible role of aquaporin-9 (AQP9) in mediating the uptake of arsenic trioxide in APL and other haematological malignancies; to examine the regulation of aquaporin-9 expression in myeloid cells.

Project Title:	The role of peptidy-proply1-isomerase PIN1 in the pathogenesis of hepatocellular carcinoma
Investigator(s):	Tse EWC, Kwong YL
Department:	Medicine
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2003

Abstract:

To examine the expression of PIN1 in HCC both at the RNA and the protein levels as compared with that in paired non-cancerous liver tissue, using semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR), immunohistochemistry and Western blot analysis; to document PINI as an oncogene involved in the development of HCC by a transgenic mouse model.

Project Title:	The role of LIM-only protein, LM04, in the pathogenesis of sporadic ovarian cancer in Chinese
Investigator(s):	Tse EWC, Kwong YL
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Abstract:

To assess the level of expression of LMO4 in sporadic ovarian cancer; to determine correlation between LMO4 expression and BRCA1 mutations in sporadic ovarian cancer; to determine correlation between LMO4 expression and clinical behaviour of sporadic ovarian cancer.

Project Title:	The role of peptidy-proplyl-isomerase PIN1 in the pathogenesis of hepatocellular carcinoma
Investigator(s):	Tse EWC
Department:	Medicine
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2004

Abstract:

Refer to hard copy

Project Title:	The study of PIN1 over-expression in multiple myeloma
Investigator(s):	Tse EWC, Kwong YL
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Abstract:

To investigate if PIN1 is over-expressed in myeloma cells; to study the effect of PIN1 down-regulation on the proliferation of myeloma cells.

List of Research Outputs

Au W.Y., Ma S.Y., Chim J.C.S., Choy C., Loong F., Lie A.K.W., Lam C.C.K., Leung A.Y.H., Tse E.W.C., Yau C.C., Liang R.H.S. and Kwong Y.L., Clinicopathologic features and treatment outcome of mature T-cell and natural killer-cell lymphomas diagnosed according to the World Health Organization classification scheme: a single center experience of 10 years, Annals of Oncology. 2005, 16(2): 206-214.

Au W.Y., Chim J.C.S., Lie A.K.W., Leung A.Y.H., Tse E.W.C., Ma S.Y., Liang R.H.S., Pang A.W.K., Kumana C.R. and Kwong Y.L., Treatment of relapsed acute promyelocytic leukemia by arsenic-based strategies without hematopoietic stem cell transplantation in Hong Kong: a seven-year experience, American Society of Haematology Annual Scientific Meeting. 2004.

Lie A.K.W., Au W.Y., Ma S.Y., Leung A.Y.H., Tse E.W.C., Chan G.C.F., Ha S.Y., Lau Y.L., Kwong Y.L. and Liang R.H.S., Haemopoietic stem cell transplantation in Hong Kong – 14 years of experience at Queen Mary Hospital, 10th Congress of the International Society of hematology, Asian Pacific Division, Nagoya, Japan. Nagoya, Japan, 2004.

Ma S.Y., Au W.Y., Lie A.K., Ng I.O.L., Leung A.Y.H., Tse E.W.C., Liang R.H.S., Lau G. and Kwong Y.L., Liver graft-versus-host disease after donor lymphocyte infusion for relapses of hematologic malignacies post allogeneic hematopoietic stem cell transplantation, Bone Marrow Transplant. 2004, 34: 57-61.

Pang R.W.C., Lee K.W., Man K., Poon R.T.P., Fan S.T., Kwong Y.L. and Tse E.W.C., RNAi-mediated silencing of PIN1 inhibits HCC tumorigenicity (Abstract) , The 96th Annual Meeting of the American Association for Cancer Research, Anaheim, California, U.S.A., 16-20 April 2005.

Pang W.C., Lee K.W., Man K., Poon R.T.P., Fan S.T., Kwong Y.L. and Tse E.W.C., Inhibition of hepatocellular carcinoma tumourigenicity by RNAi-mediated PIN1 silencing (Abstract), The 6th Annual Scientific Meeting, Centre for the Study of Liver Disease, The University of Hong Kong, Hong Kong, 8 January 2005.

Pang W.C., Lee K.W., Man K., Poon R.T.P., Fan S.T., Kwong Y.L. and Tse E.W.C., RNAi-mediated PIN1 silencing inhibits HCC trumourigenicity (Abstract), Asian Journal of Surgery. 2005, 28(Suppl 2): S84.

Pang W.C., Lee K.W., Man K., Poon R.T.P., Fan S.T., Kwong Y.L. and Tse E.W.C., RNAi-mediated PIN1 silencing inhibits HCC tumourigenicity (Abstract), The 4th International Meeting on Hepatocellular Carcinoma: Eastern and Western Experiences, Hong Kong, 14-16 December 2004.

Pang W.C., Lee K.W., Man K., Poon R.T.P., Fan S.T., Kwong Y.L. and Tse E.W.C., RNAi-mediated silencing of PIN1 inhibits HCC tumorigenicity, The 11th Hong Kong International Cancer Congress, Hong Kong, 10-12 November, 2004.

Tse E.W.C., Distinguished Research Paper Award for Young Investigator, Hong Kong College of Physicians. 2004.

Tse E.W.C. and Liang R.H.S., Natural killer cell neoplasms, Clinical lymphoma. 2004, 5(3): 197-201.

Tse E.W.C., RGC Clinical Research Fellowship, Research Grant Council, Hong Kong. 2005.

Wong D.K.H., Yuen R.M.F., Tse E.W.C., Yuan H., Sum S.M., Hui C.K. and Lai C.L., Detection of Intrahepatic Hepatitis B Virus DNA and Correlation with Hepatic Necroinflammation and Fibrosis, Journal of Clinical Microbiology. 2004, 42: 3920-3924.

Researcher : Tse EYY

List of Research Outputs

Lam C.L.K., Tse E.Y.Y. and Gandek B., Is the standard SF-12 Health Survey valid and equivalent for a Chinese population?, Quality of Life Research. 2005, 14(2): 539-547.

Researcher : Tse HF

Project Title:	Neovascularization of ischemic myocardium by autologous bone marrow cells transplantation
Investigator(s):	Tse HF, Lau CP, Kwong YL, Nicholls JM
Department:	Medicine
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2002

Abstract:

The aim of this study is to compare the effect of bone marrow endothelial progenitor cells versus bone marrow mononuclear cells (MNCs) transplantation on neovascularization, cardiomyocyte apoptosis, collagen deposition and myocardial function in an animal model of chronic myocardial ischemia. The results of this study will provide important information regarding the optimal use and the basic mechanisms of autologous bone marrow transplantation for enhancement of neovascularization and improving heart function in patients with "end-stage" IHD.

Project Title:	Embryonic stem cell transplantation as a novel therapy for post-infarct left ventricular remodeling
Investigator(s):	Tse HF, Cheah KSE, Lau CP, Zhang JCL
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	10/2002
Completion Date:	09/2004

Abstract:

To establish a mouse model of myocardial infarction; to establish the system for measuring hemodynamic changes associated with heart failure in mice; to follow the fate of undifferentiated embryonic stem cell transplanted into an infarcted heart.

Project Title:	Cellular cardiomyoplasty using embryonic stem cell transplantation as a novel therapy for myocardial repair
Investigator(s):	Tse HF, Lau CP, Li GR, Zhang JCL
Department:	Medicine
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2003

Abstract:

To use a murine model of myocardial infarction (MI) to address whether differentiation status of embryonic stem (ES) cells is important in salvaging heart function in chronic heart failure, and to determine the optimal timing of ES cell transplantation as a novel therapy after MI.

Project Title:	Comparative evaluation of platelet and coagulation activation between transvenous cryoablation and radiofrequency ablation for pulmonary vien isolation in patients with atrial fibrillation
Investigator(s):	Tse HF, Lau CP, Kwong YL
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Abstract:

To compare the potential thrombogenic risk of transvenous cryoablation versus conventional radiofrequency energy during pulmonary vein (PV) ablation procedure for treatment of atrial fibrillation (AF).

Project Title:	Direct intramyocardial implantation of autologous bone marrow cells for enhancement of neovascularization in patients with "End-Staged" coronary artery disease
Investigator(s):	Tse HF, Lau CP, Kwong YL
Department:	Medicine
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	01/2004

Abstract:

To determine the safety and efficacy of direct intramyocardial delivery of bone marrow cells using electromechanical guided injection; to investigate the angiogenic ability of implanting autologous bone marrow cells in patients with end-stage coronary artery disease.

Project Title:	Functional role of pacemaker current, I(f) in sinoatrial node probed by somatic gene transfer of bioengineered HCN channels in swine
Investigator(s):	Tse HF, Lau CP, Li GR, Li R.
Department:	Medicine
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2004

Abstract:

To demonstrate the efficacy of gene transfer technique to SA node of pigs in vivo by delivering of adenoviral vectors encoding the green fluorescent protein (GFP); to modulate the pacing activity of native endogenous pacemaker cells (SA nodal cells) via dominant-negative suppression by HCNI-AAA or overexpression of HCN constructs with distinct activation profiles using adenoviral vectors.

Project Title:	Relationship between endothelial progenitor cells and markers of thrombogenesis and platelet activation in atrial fibrillation
Investigator(s):	Tse HF, Lau CP, Kwong YL
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Abstract:

We hypothesise a relationship between the numbers of circulating EPCs and the markers of coagulation, platelet activiation and inflammation in patients with AF; we hypothesis that the numbers of circulating EPCs and vascular endothelial function predicts the outcome of cardioversion for AF.

Project Title:	Functional role of pacemaker current, I(f) in sinoatrial node probed by somatic gene transfer of bioengineered HCN channels in swine
Investigator(s):	Tse HF
Department:	Medicine
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

Refer to hard copy

List of Research Outputs

Chen W.H., Lee P.Y., Ng W., Kwok J.Y.Y., Cheng X., Tse H.F. and Lau C.P., Prevalence profile, and predictors of aspirin resistance measured by the Ultegra Rapid Platelet Function Assay-ASA in patients with coronary artery disease, J Am Coll Cardiol. 2005, 45: 382A.

Cheung B.M.Y., Man Y.B., Tse H.F., Kumana C.R. and Lau C.P., Advantages of Blood Pressure Optimisation Study, J Hong Kong Coll Cardiol . 2004, 12: 33.

Ip M.S.M., Tse H.F. and Lam B., Rebuttal to "vascular dysfunction may be mediated by other mechanisms", American Journal of Respiratory and Critical Care Medicine. 2004, 170: 197-198.

Knight B.P., Gersh B.J., Carlson M.D., Friedman P.A., McNamara R.L., Strickberger S.A., Tse H.F. and Waldo A.L., Role of permanent pacing to prevent atrial fibrillation:science advisory from the American Heart Association Council on Clinical Cardiology(Subcommittee on Electrocardiography and Arrhythmias) and the Quality fo Care and Outcomes Research Interdisciplinary Working Group, in collaboration with the Heart Rhythm Society., Circulation. 2005, 111(2): 240-3.Review.

Kwong Y.L., Tse H.F. and Lau C.P., Comparative evaluation of platelet and coagulation activation during transvenous cryoablation and radiofrequency ablation for pulmonary veinablation in patients with atrial fibrillation, J Am Coll Cardiol 2005. 45: 120A.

Sin P.Y., Tse H.F., Siu C.W., Tsang V.Y.C., Lam C.L.K. and Lau C.P., Impairment of quality-of-life in patients with atrial fibrillation. In Tse HF, Tse TF, Lau CP, Woo KS(eds), First Global Conference on Cardiovascular Clinical Trials and Pharmacotherapy - 2nd WHF Global Conference on Cardiovascular Clinical Trials and 13th International Society of Cardiovascular Pharmacotherapy Congress. Italy, Monduzzi Editore, 2005, 45-50.

Sin P.Y., Lau C.P. and Tse H.F., Quality of life in patients with atrial fibrillation., J HK Coll Cardiol. 2005, 13: 10-15.

Sin P.Y., Tse H.F., Siu C.W., Tsang V.Y.C., Lam C.L.K. and Lau C.P., Successful pulmonary vein isolation using transvenous catheter cryoablation improves quality-of-life in patients with atrial fibrillation. In Tse HF, Tse TF, Lau CP, Woo KS (eds):, First Global Conference on Cardiovascular Clinical Trials and Pharmacotherapy - 2nd WHF Global Conference on Cardiovascular Clinical Trials and 13th International Society of Cardiovascular Pharmacotherapy Congress. Italy, Monduzzi Editore, 2005, 51-56.

Siu C.W., Tse H.F., Lee K.L.F., Lam Y.M., Yung L.Y. and Lau C.P., A rapid ultrasonic cardiac output monitor method for optimization of ventriculo-ventricular interval (VVI) in cardiac resynchronization therapy., Heart Rhythm. 2005, 2: S84.

Siu C.W., Tse H.F. and Lau C.P., Inappropriate implantable cardioverter defibrillator shock from a transcutaneous muscle stimulation device therpay., J Interv Card Electrophysiol. 2005, 13(1): 73-5.

Siu C.W., Tung H.M., Lau C.P., Chu K.W., Jim M.H. and Tse H.F., Prevalence and clinical predictors for new-onset postoperative atrial fibrillation after elective abdominal surgery for colorectal cancer., Pacing Clin Electrophysiol. 2005, 28: S120-123.

Siu C.W., Jim M.H. and Tse H.F., Pulmonary artery obstruction mimicking the clinical features of acute pulmonary embolism., Heart. 2005, 91(2): 212.

Siu C.W., Chan R.H.W., Tse H.F., Lau C.P., Jim M.H., Ho H.H. and Chu F., Recurrent acute heart failure caused by sliding hiatus hernia. , Postgrad Med Journal. 2005, 81(954): 268-9.

Siu C.W., Tse H.F. and Lau C.P., Thyrotoxic Heart Disease, J HK Coll Cardiol . 2005, 13: 16-20.

Siu D.C.H., Yeung C.Y., Kung A.W.C., Lau C.P. and Tse H.F., Prevalence, clinical characteristics and outcomes of thyrotoxic dilated cardiomyopathy as the initial presentation in patients with thyrotoxicosis, American Heart Association Annual Scientific Meeting, November 7 - 10, 2004, New Orleans, USA. 2004.

Tse H.F., Lau C.P., Tsang V.Y.C., Siu C.W., Yu C., Park E., Bornzin G.A. and Benser M.E., Blood pressure response to transition from supine to standing posture using an orthostatic response algorithm., Pacing Clin Electrophysiol. 2005, 28 Suppl 1: S242-5.

Tse H.F., Lee P.Y. and Lau C.P., Bone Marrow Cell Transplantation for Myocardial Regeneration and Therapeutic Angiogenesis., Laham R, Balm DS (eds). In. Angiogenesis and Direct Myocardial Revascularization. Totowa, NJ. Humana Press Inc, 2005, 261-281.

Tse H.F., Chairman, Organizing Committee,, Joint Clinical Symposium of Heart, Brain, Hormone and Healthy Aging Centre of The Unviersity of Hong Kong and Mayo Clinic: New Diagnostic and Therapeutic Techniques for Aging Diesease. Hong Kong, 2005.

Tse H.F., Ripley K.L., Zhang Q., Siu C.W., Van V.L.E.E.T. .J.F. and Lau C.P., Cryothermal cooled radiofrequency ablation increases lesion size without without risk of thrombus formation., Eur Heart J 2005.

Tse H.F., Editorial Consultants, Journal of American College of Cardiology. 2005.

Tse H.F., Lee K.L.F., Lau C.P., Ripley K.L., Siu C.W., Van Vleet J.F. and Pelkey W.L., Effects of temporal application parameters on lesion dimensions during transvenuous catheter cryoablation, J Cardiovasc Electrophysiol. 2005, 16(2): 201-4.

Tse H.F., Lau C.P., Newman D., Ellenbogen K.A., Buhr T. and Markowitz T., Effects of ventricular rate regularization pacing on quality of life and symptoms in patients with atrial fibrillation (Atrial fibrillation symptoms medicated by pacing to mean rates [AF SYMPTOPMS study]., Am J Cardiol. 2004, 94(7): 938-41.

Tse H.F., Faculty Member, European Society of Cardiology Congress, Stockholm, Sweden. 2005.

Tse H.F., Tse T.F., Lau C.P. and Woo K.S., First Global Conference on Cardiovascular Clinical Trials and Pharmacotherapy - 2nd WHF Global Conference on Cardiovascular Clinical Trials and 13th International Society of Cardiovascular Pharmacotherapy Congress, Monduzzi Editore, Bologna, Italy. 2005.

Tse H.F. and Lau C.P., Impact of duration of cryothermal appliation on clinical efficacy of pulmonary vein isolation using transvenous cryoablation, Pacing Clin Electrophysiol. 2005, 28: 839-43.

Tse H.F., Siu C.W., Lee K.L.F., Tang M.O., Tsang V.Y.C., Chan H.W. and Lau C.P., Incremental benefit of rate adaptive pacing onexercise performance during cardiac resynchronization therapy., Heart Rhythm. 2005, 2: S166.

Tse H.F., Invited Speaker, 13th Annual Scientiifc Congress of HK College of Cardiology:Stem Cell Therapy in Treatment of Cardiovascular Disease. Hong Kong, 2005.

Tse H.F., Invited Speaker, 4th Asian Pacific Congress of Hypertension, Seoul, Korea: Endothelial Dysfunction in Hypertension: Micro and Macrovascular Abnormalities, Korea. Korea, 2005.

Tse H.F., Invited Speaker, An International Symposium in Chang Gung Memorial Hospital: Bone Marrow Stem Cell Therapy for Angiogenesis, Taiwan. Taiwan, 2005.

Tse H.F., Invited Speaker, Hong Kong Surgical Forum: Stem Cells: the future of myocardial failure. Hong Kong, 2005.

Tse H.F., Invited Speaker, Seminar "Therapeutic implication of Endothelial Progenitor Cellss", Shanghai Institues for Biological Science, Chinese Academy of Science & Shanghai Second Medical University. 2005.

Tse H.F., Invited Speaker, The 1st China Symposium on Stem Cell Transplantation in Cardiovascular Disease adn The 2nd National Symposium on Stem Cells Implantation in End-Stage Cardiovascular, Shanghai, China. 2005.

Tse H.F., Panel Member, Heart to heart meeting, Vascular Leadership Symposium: Atrial Fibrillation Ablation, Thailand. Thailand, 2005.

Tse H.F. and Lau C.P., Prevalence and clinical implications of atrial fibrillation episodes detected by pacemaker in patients with sick sinus syndrome., Heart. 2005, 91(3): 362-4.

Tse H.F., Tsang V.Y.C., Lam C.L.K., Lau C.P., Sin P.Y. and Siu C.W., Successful pulmonary vein isolation using transvenous catheter cryoablation improves quality-of-life in patients with atrial fibrillation, Pacing Clin Electrophysiol. 2005, 28(5): 421-4.

Wong K.K.K., Wu E.X., Tse H.F. and Yang E.S., Myocardial Perfusion Image Registration Using Normalized Mutual Information, 12th ISMRM. 2005, 2788.

Yiu M.W.C., Ooi C.G.C., Tse H.F., Lau C.P., Leong Fung L.L.Y. and Leong Fung L.L.Y., Multi-detector row CT mapping of the left atrium and pulmonary vein for radiofrequency and cryo-ablation for atrial fibrillation:Pre-operative findings and post-operative complications., 12th Annual Scientific Meeting, Hong Kong College of Radiologists.. 2004.

Zhang Q.Y., Tse H.F., Chen J.Z., Zhang Q.G. and Ge J.B., Mast cells contribute to angiogenesis after coronary microembolization. In Tse HF, Tse TF, Lau CP, Woo KS (Eds), First Global Conference on Cardiovascular Clinical Trials and Pharmacotherapy - 2nd WHF Global Conference on Cardiovascular Clinical Trials and 13th International Society of Cardiovascular Pharmacotherapy Congress.. Italy, Monduzzi Editore, 2005, 87-90.

Researcher : Tse TF

List of Research Outputs

Tse H.F., Tse T.F., Lau C.P. and Woo K.S., First Global Conference on Cardiovascular Clinical Trials and Pharmacotherapy - 2nd WHF Global Conference on Cardiovascular Clinical Trials and 13th International Society of Cardiovascular Pharmacotherapy Congress, Monduzzi Editore, Bologna, Italy. 2005.

Researcher : Tsoi TH

List of Research Outputs

Mak W., Tsang K.L., Tsoi T.H., Au Yeung K.M., Chan K.H., Cheng T.S., Cheung R.T.F. and Ho S.L., “Thundery Shower”: a novel headache syndrome, 17th Annual Scientific Meeting, The Hong Kong Neurological Society. 2004, 10: 30.

Tsoi T.H. and Cheung R.T.F., Workshop VI: NIHSS training and certification, Hong Kong Stroke Symposium & Workshop 2004. 5: 64-67.

Researcher : Tu S

List of Research Outputs

Gu Q., Wang J., Xia H.H.X., Lin M.C., He H., Zou B., Tu S., Yang Y., Liu X.G., Lam S.K., Wong R.W.M., Chan O.O., Yuen R.M.F., Kung H. and Wong B.C.Y., Activation of the Caspase-8/Bid and Bax Pathways in Aspirin-Induced Apoptosis in Gastric Cancer, Carcinogenesis. 2005, 26(3): 541-546.

Jiang X., Tu S., Cui J., Lin M.C., Xia H.H.X., Wong R.W.M., Chan O.O., Yuen M.F., Jiang S.H., Lam S.K., Kung H., Soh J.W., Weinstein I.B. and Wong B.C.Y., Antisense Targeting Protein Kinase C Alpha and Beta1 Inhibits Gastric Carcinogenesis, Cancer Research. 2004, 64: 5787-5794.

Tu S., Cui J., Liston P., Jiang X., Xu R., Lin M.C., Zhu Y.B., Zou B., Ng S.M., Jiang S.H., Xia H.H.X., Wong R.W.M., Chan O.O., Yuen R.M.F., Lam S.K., Kung H. and Wong B.C.Y., Gene Therapy for Colon Cancer by Adeno-Associated Viral Vector-Mediated Transfer of Survivin Cys84Ala Mutant, Gastroenterology. 2005, 128: 361-375.

Researcher : Wang J

List of Research Outputs

Gu Q., Wang J., Xia H.H.X., Lin M.C., He H., Zou B., Tu S., Yang Y., Liu X.G., Lam S.K., Wong R.W.M., Chan O.O., Yuen R.M.F., Kung H. and Wong B.C.Y., Activation of the Caspase-8/Bid and Bax Pathways in Aspirin-Induced Apoptosis in Gastric Cancer, Carcinogenesis. 2005, 26(3): 541-546.

Gu Q., Xia H.H.X., Wang W., Wang J., Wong R.W.M., Chan O.O., Yuen M.F., Lam S.K., Cheung K.L., Liu X.G. and Wong B.C.Y., Effect of Cyclo-Oxygenase Inhibitors on Helicobacter pylori Susceptibility to Metronidazole and Clarithromycin, Alimentary Pharmacology and Therapeutics. 2004, 20: 675-681.

Wang J., Zou B., Gu Q., Jiang B., Zhuang Z., Xia H.H.X., Lin M.C., Lam S.K., Kung H. and Wong B.C.Y., Down-regulation of XAF1 expression by its interacting protein FHL2 via p53-mediated transcription regulation, Gastroenterology. 2005, 128(4 Suppl 2): A105.

Wang J., Gu Q., He H., Jiang B., Zhuang Z., Xia H.H.X., Lin M.C., Lam S.K., Kung H. and Wong B.C.Y., Down-regulation of XIAP associated factor 1 (XAF1) through Hsf-1 binding in the promoter region, Gastroenterology. 2005, 128(4 Suppl 2): A105.

Zhu S., Xia H.H.X., Lam S.K., Yu L., Yang Y., Sun Y., Wang J., Chan O.O. and Wong B.C.Y., Alterations of gastric homeoprotein expression in H. Pylori infection and/or intestinal metaplasia, Gastroenterology. 2005, 128(4 Suppl 2): A598.

Researcher : Wang W

List of Research Outputs

Gu Q., Xia H.H.X., Wang W., Wang J., Wong R.W.M., Chan O.O., Yuen M.F., Lam S.K., Cheung K.L., Liu X.G. and Wong B.C.Y., Effect of Cyclo-Oxygenase Inhibitors on Helicobacter pylori Susceptibility to Metronidazole and Clarithromycin, Alimentary Pharmacology and Therapeutics. 2004, 20: 675-681.

Wong R.W.M., Xiao S.D., HU P.J., Wang W., Gu Q., Huang J., Xia H.H.X., WU S.M., LI C.J., CHEN M.H., CUI Y., Lai K.C., Hu H.C., Chan C.K., Lam S.K. and Wong B.C.Y., Standard treatment for Helicobacter pylori infection is suboptimal in non-ulcer dyspepsia compared to duodenal ulcer in Chinese, Alimentary Pharmacology and Therapeutics. 2005, 21: 73-81.

Researcher : Wang Y

List of Research Outputs

Lam K.S.L., Xu A., Tan K.C.B., Wang Y., Dan Q., Chung S.K. and Chung S.S.M., Inflammation and diabetic atherosclerosis: New players in the field, Int Atherosclerosis Society 2005 Commentaries (Epub). 2005.

Wang Y., Lam K.S.L., Xu J.Y., Lu G., Xu L.Y., Cooper G.J. and Xu A., Adiponectin inhibits cell proliferation by interacting with several growth factors in oligomerization-dependent manner , Journal of Biological Chemistry. 2005, 280(18): 18341-7.

Wang Y., Dong M., Lau C.P. and Li G.R., Modulation of human Ehter-a-go-go-related potassium (hERG) channels by protein tyrosine kinases, Journal of Hong Kong College Cardiology. 2004, 12(3/4): 102(P15).

Wang Y., Lu G., Wong W.P., Vliegenthart J.F., Gerwig G.J., Lam K.S.L., Cooper G.J. and Xu A., Proteomic and functional characterization of endogenous adiponectin purified from fetal bovine serium, Proteomics. 2004, 4(12): 3933-42.

Xu A., Lam M.C., Chan K.W., Wang Y., Zhang J.C.L., Xu J., Chen B., Chow W.S., Tso A.W. and Lam K.S.L., Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice, Proc Natl Academic Science USA. 2005, 102(17): 6086-91.

Xu A., Wong L.C., Wang Y., Xu J., Cooper G.J. and Lam K.S.L., Chronic treatment with growth hormone stimulates adiponectin gene expression in 3T3-L1 adipocytes, FEBS Letters. 2004, 572(1-3): 129-34.

Xu A., Chan K.W., Hoo R.L.C., Wang Y., Tan K.C.B., Zhang J.C.L., Chen B., Lam M.C., Tse C., Cooper G.J. and Lam K.S.L., Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes, J Biol Chem. 2005, 280(18): 18073-80.

Researcher : Wang Y

List of Research Outputs

Researcher : Wang Y

List of Research Outputs

Researcher : Wat NMS

List of Research Outputs

Cheung B.M.Y., Lam T.H., Lam K.S.L., Tam S., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Man Y.B., Cheng C.H., Kumana C.R. and Lau C.P., Follow Up of the Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., High Blood Pressure is Related to Obesity in Hong Kong, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Lipid Profile of the Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Obesity in the Hong Kong Cardiovascular Risk Factor Prevalence Survey-2 (CRISPS2) Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of Diabetes Mellitus (DM) in the Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong 2004.

Cheung B.M.Y., Man Y.B., Wat N.M.S., Lo L.F., Chau F.Y., Lam T.H., Leung G.M., Tam S., Cheng C.H., Kumana C.R., Lau C.P. and Lam K.S.L., Prevalence of Hypertension in Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort, J Hong Kong Coll Cardiol. 2004, 12: 33.

Cheung B.M.Y., Man Y.B., Lo L.F., Chau F.Y., Law C.Y., Lam K.S.L., Lam T.H., Wat N.M.S., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Relationship Between Hypertension and Obesity in Hong Kong, 3rd Asian-Pacific Congress on Hypertension, Singapore 2004.

Cheung B.M.Y., Lam T.H., Lam K.S.L., Tam S., Wat N.M.S., Man Y.B., Cheng C.H., Kumana C.R. and Lau C.P., The Hong Kong Cardiovascular Risk Factor Prevalence Survey Cohort - Results at 7 Years, J Hypertens. 2004, 22 (Suppl 2): S268-269.

Man Y.B., Cheung B.M.Y., Lam K.S.L., Wat N.M.S., Lo L.F., Chau F.Y., Law C.Y., Lam T.H., Leung G.M., Tam S., Cheng C.H., Kumana C.R. and Lau C.P., Prevalence of Hypertension in the Hong Kong Cardiovascular Risk Factor Prevalence Study Cohort, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong. 2004.

Tso A.W.K., Wat N.M.S., Xu A., Sham P.C., Rong R., Cheng K.Y., Fong H.Y., Janus E.D. and Lam K.S.L., The adiponectin gene G276T polymorphism is a risk factor for the development of the metabolic syndrome over a period of 5 years in southern Chinese, 12th International Congress of Endocrinology, Aug 31 – Sep 4, 2004, Lisbon, Portugal. 2004, 318 P949.

Wat N.M.S., Tso A.W.K., Xu A., Sham P.C., Rong R., Cheng K.Y., Fong H.Y., Janus E.D. and Lam K.S.L., The adiponectin gene T45G polymorphism is associated with central obesity and persistent glucose intolerance in high-risk Chinese subjects over 5 years, 12th International Congress of Endocrinology, Aug 31 – Sep 4, 2004, Lisbon, Portugal. 2004.

Xu J., Dan Q., Chan V.N.Y., Wat N.M.S., Tam S., Tiu S.C., Lee K.F., Siu S.C., Tsang M.W., Fung L.M., Chan K.W. and Lam K.S.L., Genetic and Clinical Characteristics of Maturity-onset Diabetes of the Young in Chinese Patients, European Journal of Human Genetics. 2005, 13: 422-427.

Xu J., Wat N.M.S., Xu A., Cheng K.Y., Sham P.C., Janus E.D. and Lam K.S.L., The G/G Genotype of the -420 C→G Polymorphism in the Resistin Gene Promoter Is Associated with Post-Challenge Glycaemia in Southern Chinese, The Endocrine Society’s 87th Annual Meeting, June 4-7, 2005, San Diego, USA. 2005.

Xu J., Wat N.M.S., Xu A., Cheng K.Y., Sham P.C., Janus E.D. and Lam K.S.L., The G/G genotype of the ->G polymorphism in the resistin gene promoter is associated with post-challenge glycaemia in Southern Chinese, 10th Medical Research Conference, The University of Hong Kong. 19-20 Feb 2005. Endocrinology 26.

Researcher : Wong BCY

Project Title:	Effect of XAF1 gene on tumor growth in gastric and colon cancer
Investigator(s):	Wong BCY, Tu S
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2003

Abstract:

To study the effect of XAF1 on tumor growth.

Project Title:	Regulation of hTERT in relation to non-steroidal anti-inflammatory drugs in gastronintestinal carcinogenesis
Investigator(s):	Wong BCY, Lin MC
Department:	Medicine
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	10/2003

Abstract:

Identify the cis-element responsible for NSAIDs-mediated inhibition of hTERT transcription; charaterize the transcription factor(s) and binding sites that is responsible for NSAIDs-mediated inhibition of hTERT transcription.

Project Title:	Regulation of hTERT in relation to non-steroidal anti-inflammatory drugs in gastronintestinal carcinogenesis
Investigator(s):	Wong BCY, Lin MC
Department:	Medicine
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	10/2003

Abstract:

Project Title:	Role of Bcl-2 family proteins in non-steroidal anti-inflammatory drug-induced apoptosis of gastric cancer
Investigator(s):	Wong BCY, Xia HHX
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2004

Abstract:

To clarify the role of Bcl-2 family proteins in NSAID-induced apoptosis in vitro in this proposal using gastric cancer cell lines.

Project Title:	Helicobacter pylori infection and CpG island methylation in gastric carcinogenesis
Investigator(s):	Wong BCY, Epstein R, Chan OO, Issa J.P., Rashid A.
Department:	Medicine
Source(s) of Funding:	Michael Kadoorie Cancer Genetics Research Fund
Start Date:	10/2004

Abstract:

To investigate if CpG island methylation at E-cadherin, as well as other tumor suppressor genes, in normal human gastric mucosa can be reversed by eradicating H. pylori; to establish an animal model to study the regulatory mechnaism of CpG island methylation at E-cadherin in gastirc cancer cell lines by Helicobacter pylori and interleukin 1.

List of Research Outputs

Chan O.O., Chu K.M., Sun Y., Cheung K.L., Lam S.K., Yuen R.M.F., Hui W.M. and Wong B.C.Y., The association between Interleukin 1 beta polymorphism and hypermethylation at tumor suppressor genes in gastric cancer. Conference paper at the Annual Meeting of the American Gastroenterology Associatoin, Digestive Diseases Week (DDW) Chicago, Illinois, USA. May 14-19, Gastroenterology. 2005, 128(4 Suppl 2): A399.

Ding H., Wand B.E., Jia J.D., Xia H.H.X., Wong B.C.Y., Zhao C.H. and Xu Y.L., Effects of octreotide on expression of L-type voltage-operated calcium channels and on intracellular Ca2+ in activated hepatic stellate cells, Chinese Medical Journal. 2004, 117(6): 913-916.

Fan X.M., Zheng F.S., Liu H.Y., Ma Y.H., Yu H.F., Jiang M. and Wong B.C.Y., Inhibition of Akt/PKB-cytochrome c by a COX-2 inhibitor induced apoptosis of gastric cancer cell, Chinese Journal of Digestive Diseases. 2005, 6(Suppl 1): A62.

Fan X.M., Zheng F.S., Liu H.Y., Ma Y.H. and Wong B.C.Y., Mechanism of apoptosis induced by specific COX-2 inhibitor SC236 in gastric cancer cells , Zhonghua Zhong Liu Za Zhi (Chinese). 2005, 27(3): 145-147.

Gu Q., Wang J., Xia H.H.X., Lin M.C., He H., Zou B., Tu S., Yang Y., Liu X.G., Lam S.K., Wong R.W.M., Chan O.O., Yuen R.M.F., Kung H. and Wong B.C.Y., Activation of the Caspase-8/Bid and Bax Pathways in Aspirin-Induced Apoptosis in Gastric Cancer, Carcinogenesis. 2005, 26(3): 541-546.

Gu Q., Xia H.H.X., Wang W., Wang J., Wong R.W.M., Chan O.O., Yuen M.F., Lam S.K., Cheung K.L., Liu X.G. and Wong B.C.Y., Effect of Cyclo-Oxygenase Inhibitors on Helicobacter pylori Susceptibility to Metronidazole and Clarithromycin, Alimentary Pharmacology and Therapeutics. 2004, 20: 675-681.

Huang J., Zheng G., Hunt R.H., Wong R.W.M., Lam S.K., Karlberg J.P.E. and Wong B.C.Y., Do patients with non-ulcer dyspepsia respond differently to Helicobacter pylorieradication treatments from those with peptic ulcer disease? A systemic review, World Journal of Gastroenterology. 2005, 11 (18): 2726-2732.

Huang J., Zheng G., Chan G.C.F., Karlberg J.P.E., Lam S.K. and Wong B.C.Y., Efficacy of Current Antiemetic Treatments for Preventing Delayed Chemotherapy-Induced Nausea and Vomiting: A Meta-Analysis of Randomized Controlled Trials, Clinical Research and Regulatory Affairs. 2004, 21 (3&4): 191-212.

Hui C.K., Lai K.C., Wong R.W.M., Yuen R.M.F., Ng M.M.T., Chan C.K., Hu H.C., Cheung W.W., Lai C.L. and Wong B.C.Y., Outpatients Undergoing Therapeutic Endoscopic Retrograde Cholangiopancreatography: Six-hour Versus Overnight Observation , Journal of Gastroenterology and Hepatology. 2004, 19: 1163-1168.

Jiang X., Tu S., Cui J., Lin M.C., Xia H.H.X., Wong R.W.M., Chan O.O., Yuen M.F., Jiang S.H., Lam S.K., Kung H., Soh J.W., Weinstein I.B. and Wong B.C.Y., Antisense Targeting Protein Kinase C Alpha and Beta1 Inhibits Gastric Carcinogenesis, Cancer Research. 2004, 64: 5787-5794.

Kalia A., Mukhopadhyay A.K., Dailide G., Ito Y., Azuma T., Wong B.C.Y. and Berg D.E., Evolutionary dynamics of insertion sequences in Helicobacter pylori, Journal of Bacteriology. 2004, 186(22): 7508-7520.

Lai K.C., Hui W.M., Wong B.C.Y., Hu H.C., Chan O.O. and Lam S.K., Lansorprazole but not Rofecoxib reduced dyspeptic symptoms of patients on NSAIDS, Gastroenterology. 2005, 128(4 Suppl 2): A24.

Lewis A.E., Susarla R., Wong B.C.Y., Langman M.J. and Eggo M.C., Protein kinase C delta is not activated by caspase-3 and its inhibition is sufficient to induce apoptosis in the colon cancer line, COLO 205, Cellular signalling. 2005, 17(2): 253-262.

Li G., Xia H.H.X., Chen M.H., Chan O.O., Cho C.H., Lam S.K., Berg D., Feng Z., Langenbach R. and Wong B.C.Y., Effects of Cyclooxygenase-1 and -2 Gene Disruption on Helicobacter pylori-Induced Inflammation, Apoptosis and Proliferation, Journal of Gastroenterology and Hepatology. 2004, 19(Suppl.): A299.

Ren Z., Borody T., Pang G., Dunkley M., Clancy R., Xia H.H.X., Chu K.M., Wong J. and Wong B.C.Y., Evaluation of anti-Helicobacter pylori IgG2 antibody for the diagnosis of Helicobacter pylori infection in Western and Chinese populations, Alimentary Pharmacology & Therapeutics. 2005, 21: 83-89.

Tu S., Cui J., Liston P., Jiang X., Xu R., Lin M.C., Zhu Y.B., Zou B., Ng S.M., Jiang S.H., Xia H.H.X., Wong R.W.M., Chan O.O., Yuen R.M.F., Lam S.K., Kung H. and Wong B.C.Y., Gene Therapy for Colon Cancer by Adeno-Associated Viral Vector-Mediated Transfer of Survivin Cys84Ala Mutant, Gastroenterology. 2005, 128: 361-375.

Wang J., Zou B., Gu Q., Jiang B., Zhuang Z., Xia H.H.X., Lin M.C., Lam S.K., Kung H. and Wong B.C.Y., Down-regulation of XAF1 expression by its interacting protein FHL2 via p53-mediated transcription regulation, Gastroenterology. 2005, 128(4 Suppl 2): A105.

Wang J., Gu Q., He H., Jiang B., Zhuang Z., Xia H.H.X., Lin M.C., Lam S.K., Kung H. and Wong B.C.Y., Down-regulation of XIAP associated factor 1 (XAF1) through Hsf-1 binding in the promoter region, Gastroenterology. 2005, 128(4 Suppl 2): A105.

Wang W.H., Huang J., Zheng G., Wong R.W.M., Lam S.K., Karlberg J.P.E., Xia H.H.X., Fass R. and Wong B.C.Y., Is Proton Pump Inhibitor Testing an Effective Approach to Diagnose Gastroesophageal Reflux Disease in Patients With Noncardiac Chest Pain?, Archives of Internal Medicine. 2005, 165: 1222-1228.

Wong B.C.Y., Chan O.O., Wong K.W., Ching C.K., Wong R.W.M., Tam S., Lai K.C., Chan C.K., Yuen R.M.F. and Lam S.K., A pilot study of participation in faecal occult blood testing and screening colonoscopy after health education in Hong Kong, European Journal of Cancer Preview. 2005, 14(2): 181-184.

Wong B.C.Y., Associate Editor, since 2004, Digestive Disease Watch. 2005.

Wong B.C.Y., Associate Editor-in-chief, Chinese Journal of Gastroenterology. 2004.

Wong B.C.Y., Associate Editor-in-chief, Chinese Journal of Gastroenterology. 2005.

Wong B.C.Y., Belching and dyspepsia, Mingpao, 1 Sept 2004 . Hong Kong, 2004, D5.

Wong B.C.Y., Cancer and Health Expo, Hong Kong Commercial News, 19 Dec 2004. Hong Kong, 2004, C1.

Wong B.C.Y., Chemoprevention of colorectal cancer. , Asia Pacific Digestive Week, Beijing, PR China, October 5,. 2004.

Wong B.C.Y., Clonochis sinesis, Mingpao, 4 Nov 2004. Hong Kong, 2004, A18.

Wong B.C.Y., Colon Cancer, Economy Daily, 9 Aug 2004 . Hong Hong, 2004, A4.

Wong B.C.Y., Colon cancer screening, Mingpao, 23 Aug 2004 . Hong Kong, 2004, D07.

Wong B.C.Y., Colon cancer, Oriental Daily, 18 Aug 2004. Hong Kong, 2004, A35.

Wong B.C.Y., Colon cancer, Sing Pao, 9 Aug 2004 . Hong Kong, 2004, A2.

Wong B.C.Y., Coloon cancer incidence on rising, Sing Pao, 6 Dec 2004. Hong Kong, 2004, A12.

Wong B.C.Y., Colorectal and gastric cancer screening in Hong Kong, International Conference of Cancer Screening in Asia, Keelong, Taiwan, Oct 26. 2004.

Wong B.C.Y., Colouring of urine and stool, Sun, 24 Oct 2004. Hong Kong, 2004, A4.

Wong B.C.Y., Common GI problems in Hong Kong, Parents, Sept 2004 . Hong Kong, 2004, 148: 70-71.

Wong B.C.Y., Common gastrointestinal diseases, Luncheon Meeting organised by Lions Club of Victoria Hong Kong, 12 Jan . 2005.

Wong B.C.Y., Constipation, Mingpao, 28 Sept 2004. Hong Kong, 2004.

Wong B.C.Y., Controversies in Helicobacter pylori infection , In: , Keynote Lecture, First Guangdong Gastroenterology Meeting, Guangzhou, July 30. 2004.

Wong B.C.Y., Diagnosis and Management of resistant Helicobacter pylori infection, 62nd Hong Kong Doctors Union Sunday Symposium, October 17 . 2004.

Wong B.C.Y., Diet and GI diseases, Digestive Health Awareness Coalition Program for the Family Planning Association of HK (FPA), FPA auditorium, Wanchai, Hong Kong, April 22. 2005.

Wong B.C.Y., Dye in foood substances, Oriental Daily, 4 Oct 2004. Hong Kong, 2004, A24.

Wong B.C.Y., Dyspepsia and belching, Hong Kong Economic Times, 15 April 2005. Hong Kong, 2005, A22.

Wong B.C.Y., Early detection of colon cancer, Next Magazine, 9 Sept 2004. Hong Kong, 2004, 757: 138-139.

Wong B.C.Y., Editor, Journal of Gastroenterology and Hepatology. 2005.

Wong B.C.Y., Editorial Board, Alimentary Pharmacology and Therapeutics, since 2004. 2005.

Wong B.C.Y., Editorial Board, Carcinogenesis, since 2005. 2005.

Wong B.C.Y., Editorial Board, Chinese Journal of Digestive Diseases, since 2002. 2005.

Wong B.C.Y., Editorial Board, Digestive Endoscopy, since 2001. 2005.

Wong B.C.Y., Editorial Board, European Review for Medical and Pharmacological Sciences, since 2004. 2005.

Wong B.C.Y., Editorial Board, Gastrointestinal endoscopy, since 2004. 2005.

Wong B.C.Y., Editorial Board, Journal of Clinical Oncology, Chinese edition, since 1999.. 2005.

Wong B.C.Y., Editorial Board, MIMS Gastroenterology Guide, since 2002. 2005.

Wong B.C.Y., Editorial Board, Modern Digestion and Intervention, since 2003. 2005.

Wong B.C.Y., Editorial Board, World Journal of Gastroenterology, since 2004. 2005.

Wong B.C.Y., Expanding the horizons of small bowel endoscopy, Medical Tribune, Nov 2004. Hong Kong, 2004, i.

Wong B.C.Y., Expert advise colon cancer screening, Oriental Daily, 6 Dec 2004. Hong Kong, 2004, A18.

Wong B.C.Y., Faecal occult blood, Sun, 6 Dec 2004. Hong Kong, 2004, A22.

Wong B.C.Y., Fatal cases of Hepatitis E in Japan, Mingpao, 14 Dec 2004. Hong Kong, 2004, A18.

Wong B.C.Y., First, second and third line treatment of Helicobacter pylori infection, and capsule endoscopy , Annual refresher course, Hong Kong College of Family Physicians, Dec 10 . 2004.

Wong B.C.Y., From aspirin to apoptosis: Prevention and treatment of GI cancers, Peking University First Hospital, Beijing, PR China, 10 March . 2005.

Wong B.C.Y., Functional dyspepsia – pH, Hp or more? , Asia Pacific Digestive Week, Beijing, PR China, October 5. 2004.

Wong B.C.Y., GERD prevalence rising, Medical Tribune, Oct 2004. Hong Kong, 2004.

Wong B.C.Y., GERD rising trend in Hong Kong, Press Conference, 12 Aug 2004. Hong Kong, 2004.

Wong B.C.Y., GERD: Defining the standards of management , Symposium of Hong Kong Society of Gastroenterology and Hong Kong Society of Digestive Endoscopy, Hong Kong. April 25 . 2005.

Wong B.C.Y., GERD, Singtao, 23 Aug 2004. Hong Kong, 2004, E6.

Wong B.C.Y., Gastric cancer, Meet-the-Professor Luncheon, Digestive Disease Week, Chicago, USA, 18 May. 2005.

Wong B.C.Y., Getting the word out on GERD, Doctor. Hong Kong, 2004, 5:9: 8.

Wong B.C.Y., Guaiac vs. I-FOBTs screening experience, OMED Colorectal Cancer Screening Meeting, Chicago, USA, 15 May. 2005.

Wong B.C.Y., H pylori and GU/PU healing: new treatment options, Astrazeneca symposium on Nexium: maximize clinical benefits. Asia Pacific Digestive Week, Beijing, PR China, October 5 . 2004.

Wong B.C.Y., Helicobacter pylori and gastric cancer , 3rd Digestive Disease Seminar, Hyogo College of Medicine, Hyogo, Japan, Nov 18. 2004.

Wong B.C.Y., Helicobacter pylori and gastric cancer , In: Caritus Medical Center 40th Anniversary Scientific Symposium, Hong Kong, Nov 20. 2004.

Wong B.C.Y., Helicobacter pylori and gastric cancer , Medical Forum China, Fourth Medical Military University, Xian, China, July 20. 2004.

Wong B.C.Y., Helicobacter pylori and gastric cancer- the final story?, Alimentary Disease Weekend, The University of Hong Kong, Hong Kong, Sept 19. 2004.

Wong B.C.Y., Helicobacter pylori infection – to treat everyone? , 9th Hong Kong Medical Forum, Department of Medicine, The University of Hong Kong, July 18. 2004.

Wong B.C.Y., Helicobacter pylori infection, An invited talk organised by Lions Club of Central, Hong Kong, 19 Aug 2004. 2004.

Wong B.C.Y., Intervention Studies of gastric cancer , 5th Western Pacific Helicobacter Pylori Congress, Japan, November 18. 2004.

Wong B.C.Y., Intervention study on Helicobacter pylori and gastric cancer , 6th International Gastric Cancer Congress, Yokohama, Japan, 5 May. 2005.

Wong B.C.Y., Management of resistant Helicobacter pylori infection , Joint Thailand and Myanmar Gastroenterology Meeting, Myanmar, August 1 . 2004.

Wong B.C.Y., Managing dyspepsia in regions with a high risk of gastric cancer, Alimentary Pharmacology and Therapeutics. 2005, 21 (Suppl 1): 19-20.

Wong B.C.Y., Prevention of gastric cancer , 5th Joint Annual Scientific Meeting, Hong Kong Society of Gastroenterology, Hong Kong, October 9. 2004.

Wong B.C.Y. and Xia H.H.X., Prevention of gastric cancer by Helicobacter pylori eradication, In: Sugano K, Helicobacter pylori-associated Gastric Cander - Evidence of its Carcinogenesis. Japan, Igaku-Shoin Ltd, 2004, 69-72.

Wong B.C.Y., Proton pump inhibitor best therapy for GERD, Medical Tribune, Sept 2004. Hong Kong, 2004, 7.

Wong B.C.Y., Randomized controlled trials, In APAGE/OMGE training workshop on clinical research methods. Post-graduate course, Asia Pacific Digestive Week, Beijing, PR China, October 4. 2004.

Wong B.C.Y., Recent advances in screening and treatment of colon cancer for primary care physicians , Hong Kong College of Family Physicians Meeting, Hong Kong, 29 June. 2005.

Wong B.C.Y., Screening for colon cancer, Sing Tao Daily News, 21 Dec 2004. Hong Kong, 2004, E7.

Wong B.C.Y., Screening of colon cancer, Metro Daily, 17 Sept 2004. Hong Kong, 2004, 30.

Wong B.C.Y., Suggest colon cancer screening, Apple Daily, 6 Dec 2004 . Hong Kong, 2004, A17.

Wong B.C.Y., Targeting COX-2 in prevention and treatment of GI cancers, Genomics, Proteomics and Therapeutics in Cancer Research, Faculty of Medicine, The University of Hong Kong, Hong Kong, October 20-21 . 2004.

Wong B.C.Y., Targeting Inhibitor of Apoptosis proteins in tretment of cancer, Proceedings, Frontiers in Biomedical Research, The University of Hong Kong, Dec 2004.

Wong B.C.Y., Targeting Inhibitors of apoptosis in cancer treatment , Frontiers in biomedical research, Faculty of Medicine, The University of Hong Kong, Dec 3-4. 2004.

Wong B.C.Y., Targeting the inhibitor of apoptosis proteins in cancer treatment, Proceedings, The Croucher Advanced Study Institute "Molecular genetics and cell signalling in cancers" January 17-21, 2005.

Wong B.C.Y., Targeting the inhibitor of apoptosis proteins in cancer treatment, The Croucher Advanced Study Institute "Molecular genetics and cell signalling in cancers" January 17-21. 2005.

Wong B.C.Y., Fong D.Y.T. and Karlberg J.P.E., Translation of the Rome II Modular Questionnaire, AstraZeneca AB. 2005.

Wong B.C.Y., Update on medical management of inflammatory bowel diseases, Hong Kong Surgical Forum, July 10 . 2004.

Wong B.C.Y., Validating RDQ in the diagnosis of GERD. , GI Summit, Astrazeneca, Beijing, PR China, October 3 . 2004.

Wong B.C.Y., Wireless pH monitoring: its technology and application , GI Summit, Astrazeneca, Beijing, PR China, October 3. 2004.

Wong R.W.M., Lim P. and Wong B.C.Y., Clinical practice pattern of gastroenterologists, primary care physicians, and otolaryngologists for the management of GERD in the Asia-Pacific region: the FAST survey, Journal of Gastroenterology and Hepatology. 2004, 19(Suppl 3): S54-S60.

Wong R.W.M. and Wong B.C.Y., Colorectal Screening: Part II - Sigmoidoscopy, Colonoscopy, Double-Contrast Barium Enema and Virtual Colonoscopy, Medical Progress. 2005, 32(4): 193-197.

Wong R.W.M. and Wong B.C.Y., Constipation - an update, The Hong Kong Medical Diary. 2004, 9(6): 3-6.

Wong R.W.M. and Wong B.C.Y., Definition and diagnosis of gastroesophageal reflux disease, Journal of Gastroenterology and Hepatology. 2004, 19(Suppl 3): S26-S32.

Wong R.W.M., Hui W.M. and Wong B.C.Y., Diagnosis of Barrett's esophagus in the Asian population, Journal of Gastroenterology and Hepatology. 2005, 20(3): 495.

Wong R.W.M., Huang J., Xia H.H.X., Fung F.M.Y., Tong S.M., Cheung K.L., Ho Y.K., Lai K.C., Chan C.K., Chan O.O., Hui C.K., Lam S.K. and Wong B.C.Y., Low-dose rabeprazole, amoxicillin and metronidazole triple therapy for the treatment of Helicobacter pylori infection in Chinese patients , Journal of Gastroenterology and Hepatology. 2005, 20(6): 935-940.

Wong R.W.M., Lai K.C., Hui W.M., Hu H.C., Huang J., Wong Y.H., Xia H.H.X., Chan O.O., Lam S.K. and Wong B.C.Y., Pathophysiology of Gastroesophageal Reflux Diseases in ChineseRole of Transient Lower Esophageal Sphincter Relaxation and Esophageal Motor Dysfunction, American Journal of Gastroenterology. 2004, 99: 2088-2093.

Wong R.W.M., Hui W.M. and Wong B.C.Y., Reply from authors, Journal of Gastroenterology and Hepatology. 2005, 20(3): 495.

Wong R.W.M., Xiao S.D., HU P.J., Wang W., Gu Q., Huang J., Xia H.H.X., WU S.M., LI C.J., CHEN M.H., CUI Y., Lai K.C., Hu H.C., Chan C.K., Lam S.K. and Wong B.C.Y., Standard treatment for Helicobacter pylori infection is suboptimal in non-ulcer dyspepsia compared to duodenal ulcer in Chinese, Alimentary Pharmacology and Therapeutics. 2005, 21: 73-81.

Wong W.M., Lai K.C., Lam K.F., Hui W.M., Huang J.Q., Xia H.H.X., Hu H.C., Lam C.L.K., Chan C.K., Lam S.K. and Wong B.C.Y., Onset and disappearance of Reflux Symptoms in a Chinese population: a one-year follow-up study, Alimentary Pharmacology and Therapeutics. 2004, 20: 803-812.

Xia B., Xia H.H.X., Lam S.K., Chan O.O., Lai K.C., Hu H.C. and Wong B.C.Y., Trends in prevalence of peptic ulcer disease and Helicobacter pylori infection and frequency of NSAID intake in general practitioner-referred dyspeptic patients over 6 years in Hong Kong, Gastroenterology. 2005, 128(4 Suppl 2): A230.

Xia H.H.X., Yang Y., Lam S.K., Wong R.W.M., Leung S.Y., Yuen S.T., Elia G., Wright N.A. and Wong B.C.Y., Aberrant Epithelial Expression of Trefoil Family Factor 2 and Mucin 6 in Helicobacter pylori infected gastric antrum, incisura, and body and its association with antralisation, Journal of clinical pathology. 2004, 57: 861-866.

Xia H.H.X., Wong B.C.Y., Zhang G.S., Yang Y., Wyatt J.M., Adams S., Cheung K., Lam S.K. and Talley N.J., Antralization of Gastric Incisura is Topographically Associated with Increased Gastric Epithelial Apoptosis and Proliferation, but not with CagA Seropositivity, Journal of Gastroenterology and Hepatology. 2004, 19: 1257-1263.

Xia H.H.X., Li G., Chen M.H., Chan O.O., Cho C.H., Lam S.K., Berg D., Feng Z., Langenbach R. and Wong B.C.Y., Cyclooxygenase-1 and -2 Gene Disruption Potentiate TH1 Polarization in Response to Helicobacter pylori, Journal of Gastroenterology and Hepatology. 2004, 19(Suppl.): A366.

Xia H.H.X., Zhang S., Lam S.K., Lin M.C., Kung H. and Wong B.C.Y., Expression of Macrophage Migration Inhibitory Factor in Esophageal Squamous Cell Carcinoma and Effects of Bile Acids and NSAIDs, Carcinogenesis. 2005, 26(1): 11-15.

Xia H.H.X., Lam S.K., Chan O.O., Lin M.C., Kung H., Ogura K., Berg D.E. and Wong B.C.Y., Macrophage Migration Inhibitory Factor Stimulated by Helicobacter pylori Increases Proliferation of Gastric Epithelial Cells, World Journal of Gastroenterology. 2005, 11(13): 1946-1950.

Xia H.H.X., Lam S.K., Huang X.R., Wong R.W.M., Leung S.Y., Yuen S.T., Lan H.Y. and Wong B.C.Y., Helicobacter pylori Infection is Associated with Increased Expression of Macrophage Migratory Inhibitory Factor - by Epithelial Cells, T Cells, and Macrophages - in Gastric Mucosa, The Journal of Infectious Diseases. 2004, 190: 293-302.

Ye Y., Wu K.K., Shin V.Y., Bruce I.C., Wong B.C.Y. and Cho C.H., Dual inhibition of 5-LOX and COX-2 suppresses colon cancer formation promoted by cigarette smoke, Carcinogenesis. 2005, 26, no. 4: 827-834.

Yuen R.M.F., Wong D.K.H., Sum S.M., Yuan H., Yuen J.C.H., Chan O.O., Wong B.C.Y. and Lai C.L., Effect of lamivudine therapy on the serum covalently closed circular DNA of chronic hepatitis B infection., 55th Annual Meeting of the American Association for the Study of Liver Diseases, Boston, USA 29 Oct-2 Nov 2004 (Published in Hepatology). 2004, 40(4): 671A.

Yuen R.M.F., Wong D.K.H., Sum S.M., Yuan H., Yuen J.C.H., Chan O.O., Wong B.C.Y. and Lai C.L., Effect of lamivudine therapy on the serum covalently closed-circular (ccc) DNA of chronic hepatitis B infection., American Journal of Gastroenterology. 2005, 100(5): 1099-103.

Yuen R.M.F., Chow D.H.F., Tsui K., Wong B.C.Y., Yuen J.C.H., Wong D.K.H. and Lai C.L., Liver histology of Asian patients with chronic hepatitis B on prolonged lamivudine therapy, Alimentary Pharmacology and Therapeutics. 2005, 21(7): 841-9.

Yuen R.M.F., Yuan H., Sablon E., Wong D.K.H., Chan O.O., Wong B.C.Y. and Lai C.L., Long-term follow-up study of Chinese patients with YMDD mutations: significance of hepatitis B virus genotypes and characteristics of biochemical flares, Journal of Clinical Microbiology. 2004, 42(9): 3932-6.

Yuen R.M.F., Fung S.K., Tanaka Y., Kato T., Mizokami M., Yuen J.C.H., Wong D.K.H., Yuan H., Sum S.M., Chan O.O., Wong B.C.Y. and Lai C.L., Longitudinal study of hepatitis activity and viral replication before and after HBeAg seroconversion in chronic hepatitis B patients infected with genotypes B and C., Journal of Clinical Microbiology. 2004, 42(11): 5036-40.

Yuen R.M.F., Yuan H., Wong D.K.H., Yuen J.C.H., Wong R.W.M., Chan O.O., Wong B.C.Y., Lai K.C. and Lai C.L., Prognostic determinants for chronic hepatitis B in Asians: therapeutic implications., Gut. 2005, online.

Yuen R.M.F., Tanaka K., Mizokami M., Yuen J.C.H., Hui C.K., Wong D.K.H., Yuan H., Sum S.M., Chan O.O., Wong B.C.Y., Fan S.T. and Lai C.L., Role of hepatitis B virus genotypes Ba and C, core promoter and precore mutations on hepatocellular carcinoma: a case control study, Carcinogenesis. 2004, 25(9): 1593-1598.

Zhu S., Xia H.H.X., Lam S.K., Yu L., Yang Y., Sun Y., Wang J., Chan O.O. and Wong B.C.Y., Alterations of gastric homeoprotein expression in H. Pylori infection and/or intestinal metaplasia, Gastroenterology. 2005, 128(4 Suppl 2): A598.

Zhuang Z., Tsao G.S.W., Xia H.H.X., He H., Chan O.O., Lam S.K. and Wong B.C.Y., COX-2 inhibition induces apoptosis in human esophageal epithelial cells: implication for chemoprevention, Gastroenterology. 2005, 128(4 Suppl 2): A299.

Researcher : Wong CW

List of Research Outputs

Li V.S.W., Wong C.W., Chan T.L., Chan A.S.W., Zhao W., Chu K.M., Chen X., Yuen S.T., Leung S.Y. and So S., Mutations of PIK3CA in gastric adenocarcinoma, BioMed Central Cancer. 2005, 5: 29.

Researcher : Wong DKH

List of Research Outputs

Sum S.M., Wong D.K.H., Yuen R.M.F., Yuen H., Yu J., Lai C.L., Ho D. and Zhang L., Real-time PCR Assay Using Molecular Beacon for Quantitation of Hepatitis B Virus DNA, Journal of Clinical Microbiology. 2004, 42: 3438-3440.

Wong D.K.H., Yuen R.M.F., Tse E.W.C., Yuan H., Sum S.M., Hui C.K. and Lai C.L., Detection of Intrahepatic Hepatitis B Virus DNA and Correlation with Hepatic Necroinflammation and Fibrosis, Journal of Clinical Microbiology. 2004, 42: 3920-3924.

Wong D.K.H., Yuen R.M.F., Yuan H., Sum S.M., Hui C.K., Hall J. and Lai C.L., Quantitation of Covalently Closed Circular Hepatitis B Virus DNA in Chronic Hepatitis B Patients, Hepatology. 2004, 40: 727-737.

Yuan H., Yuen R.M.F., Wong D.K.H., Sum S.M. and Lai C.L., Clinical Evaluation of the Digene Hybrid Capture II Test and the COBAS AMPLICOR Monitor Test for Determination of Hepatitis B Virus DNA Levels, Journal of Clinical Microbiology. 2004, 42: 3513-3517.

Yuan H., Yuen R.M.F., Wong D.K.H., Sum S.M., Doutreloigne J., Sablon E. and Lai C.L., Determinants for the Occurrence of Acute Exacerbation of Hepatitis B Virus Infection in Chinese Patients after HBeAg Seroclearance , Journal of Clinical Microbiology. 2005, 43: 1594-1599.

Yuen M.F., Ng I.O.L., Fan S.T., Yuan H., Wong D.K.H., Yuen J.C.H., Sum S.M., Chan O.O. and Lai C.L., Significance of HBV DNA levels in liver histology of HBeAg and anti-HBe positive patients with chronic hepatitis B, American Journal of Gastroenterology. 2004, 99(10): 2032-2037.

Yuen R.M.F., Lim W.L., Chan O.O., Wong D.K.H., Sum S.M. and Lai C.L., 18-year follow-up study of a prospective randomized trial of hepatitis B vaccinations without booster doses in children, Clinical Gastroenterology and Hepatology. 2004, 2(10): 941-5.

Yuen R.M.F., Wong D.K.H., Sum S.M., Yuan H., Yuen J.C.H., Chan O.O., Wong B.C.Y. and Lai C.L., Effect of lamivudine therapy on the serum covalently closed circular DNA of chronic hepatitis B infection., 55th Annual Meeting of the American Association for the Study of Liver Diseases, Boston, USA 29 Oct-2 Nov 2004 (Published in Hepatology). 2004, 40(4): 671A.

Yuen R.M.F., Wong D.K.H., Sum S.M., Yuan H., Yuen J.C.H., Chan O.O., Wong B.C.Y. and Lai C.L., Effect of lamivudine therapy on the serum covalently closed-circular (ccc) DNA of chronic hepatitis B infection., American Journal of Gastroenterology. 2005, 100(5): 1099-103.

Yuen R.M.F., Wong D.K.H., Yuan H., Sum S.M. and Lai C.L., HBsAg seroclearance in Chinese patients receiving lamivudine therapy for chronic hepatitis B virus infection, Journal of Clinical Microbiology. 2004, 42(10): 4882-4.

Yuen R.M.F., Wong D.K.H., Chan C.S., Zhang Z., Yuen J.C.H. and Lai C.L., Immune Response During Immunoclearance Phase of Chinese Patients with HBV Genotypes B and C, Journal of Hepatology. 2005, 42 (Suppl 2): 152.

Yuen R.M.F., Chow D.H.F., Tsui K., Wong B.C.Y., Yuen J.C.H., Wong D.K.H. and Lai C.L., Liver histology of Asian patients with chronic hepatitis B on prolonged lamivudine therapy, Alimentary Pharmacology and Therapeutics. 2005, 21(7): 841-9.

Yuen R.M.F., Yuan H., Sablon E., Wong D.K.H., Chan O.O., Wong B.C.Y. and Lai C.L., Long-term follow-up study of Chinese patients with YMDD mutations: significance of hepatitis B virus genotypes and characteristics of biochemical flares, Journal of Clinical Microbiology. 2004, 42(9): 3932-6.

Yuen R.M.F., Fung S.K., Tanaka Y., Kato T., Mizokami M., Yuen J.C.H., Wong D.K.H., Yuan H., Sum S.M., Chan O.O., Wong B.C.Y. and Lai C.L., Longitudinal study of hepatitis activity and viral replication before and after HBeAg seroconversion in chronic hepatitis B patients infected with genotypes B and C., Journal of Clinical Microbiology. 2004, 42(11): 5036-40.

Yuen R.M.F., Kim J., Averett D., Wong D.K.H., Kim C.R., Kerr B., Ngai W.S., Yuen J.C.H. and Lai C.L., Phase I/II double-blind, randomized, placebo-controlled study of the novel anti-HBV agent LB80380/ANA380 in patients with chronic HBV infection., 55th Annual Meeting of the American Association for the Study of Liver Diseases, Boston, USA 29 Oct-2 Nov 2004 (Published in Hepatology). 2004, 40 (4 Suppl 1): 172A.

Yuen R.M.F., Yuan H., Wong D.K.H., Yuen J.C.H., Wong R.W.M., Chan O.O., Wong B.C.Y., Lai K.C. and Lai C.L., Prognostic determinants for chronic hepatitis B in Asians: therapeutic implications., Gut. 2005, online.

Yuen R.M.F., Tanaka K., Mizokami M., Yuen J.C.H., Hui C.K., Wong D.K.H., Yuan H., Sum S.M., Chan O.O., Wong B.C.Y., Fan S.T. and Lai C.L., Role of hepatitis B virus genotypes Ba and C, core promoter and precore mutations on hepatocellular carcinoma: a case control study, Carcinogenesis. 2004, 25(9): 1593-1598.

Researcher : Wong KW

List of Research Outputs

Wong B.C.Y., Chan O.O., Wong K.W., Ching C.K., Wong R.W.M., Tam S., Lai K.C., Chan C.K., Yuen R.M.F. and Lam S.K., A pilot study of participation in faecal occult blood testing and screening colonoscopy after health education in Hong Kong, European Journal of Cancer Preview. 2005, 14(2): 181-184.

Researcher : Wong LC

List of Research Outputs

Dan Q., Wong L.C., Chung S.K., Chung S.S.M. and Lam K.S.L., Interaction between the polyol pathway and non-enzymatic glycation on aortic smooth muscle cell migration and monocyte adhesion, Life Science. 2004, 76(4): 445-59.

Lam K.S.L., Xu A., Tan K.C.B., Wong L.C., Tiu S.C. and Tam S., Serum adiponectin is reduced in acromegaly and normalized after correction of growth hormone excess, Journal of Clinical and Endocrinological Metabablism. 2004, 89(11): 5448-53.

Researcher : Wong LYF

Project Title:	Involvement of NF-κB and cAMP-dependent protein kinase pathways in adrenomedullin-induced cytokine responses in macrophages
Investigator(s):	Wong LYF, Cheung BMY
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Abstract:

To assess the involvement of NF-[kappa]B pathway as the link between AM and inflammation; to confirm that AM exerts its effect on cytokine production in macrophages through cyclic-AMP; to identify the cAMP-dependent protein kinase pathway involved in the AM-induced cytokine response in LPS-stimulated macrophages.

List of Research Outputs

Cheung B.M.Y., Li Y.Y. and Wong L.Y.F., Adrenomedullin: Its Roles in the Cardiovascular System, Seminars Vasc Med. 2004, 4(2): 129-134.

Cheung B.M.Y., Leung Y.H., Man Y.B., Wong L.Y.F. and Lau C.P., Association of Blood Pressure and Obesity with a Single Nucleotide Polymorphism at 17p12, American Journal of Hypertension. 2005, 18(5) Suppl: A79.

Cheung B.M.Y., Man Y.B., Leung Y.H. and Wong L.Y.F., Association of Single Nucleotide Polymorphisms in the Urotensin II Gene with Plasma Insulin and Hypertension, American Journal of Hypertension. 2005, 18: 79A.

Cheung B.M.Y., Leung Y.H., Man Y.B. and Wong L.Y.F., Elevated Plasma Concentration of Urotensin II in Hypertension, 3rd Asian-Pacific Congress on Hypertension, Singapore 2004.

Cheung B.M.Y., Leung Y.H., Man Y.B. and Wong L.Y.F., Elevated Plasma Concentration of Urotensin II in Hypertension, J Hypertens. 2004, 22 (Suppl 2): S188.

Cheung B.M.Y., Leung Y.H., Man Y.B. and Wong L.Y.F., Plasma Concentration of Urotensin II is Raised in Hypertension, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong. 2004.

Cheung B.M.Y., Leung Y.H., Man Y.B. and Wong L.Y.F., Plasma Concentration of Urotensin II is Raised in Hypertension, J Hypertens. 2004, 22: 1341-4.

Man Y.B., Wong L.Y.F. and Cheung B.M.Y., Association of Urotensin II rs7367534 C>T Polymorphism with Hypertension, J HK Coll Cardiol . 2004, 12: 110.

Ong K.L., Wong L.Y.F., Man Y.B., Lam K.S.L. and Cheung B.M.Y., Hypertension is associated with a single nucleotide polymorphism in the uroteinsin II gene, 10th Medical Research Conference, The University of Hong Kong. 19-20 Feb 2005.

Wong L.Y.F., Cheung B.M.Y. and Tang F., Adrenomedullin is Both Proinflammatory and Antiinflammatory: Its Effects on Gene Expression and Secretion of Cytokines and Macrophage Migration Inhibitory Factor in NR8383 Macrophage Cell Line, Endocrinology. 2005, 146: 1321-1327.

Wong L.Y.F., Cheung B.M.Y. and Tang F., Expressions of Urotensin II and Urotensin II Receptor are Up-regulated in Cardiovascular Tissues in Experimentally Induced Endotoxaemia, American Journal of hypertension. 2005, 18: 125A.

Wong L.Y.F., Interleukin-6 Gene -573 G>C Promoter Polymorphism is Associated with Hypertension in Hong Kong Chinese, J HK Coll Cardiol. 2004, 12: 110.

Wong L.Y.F., Man Y.B., Leung Y.H. and Cheung B.M.Y., Interleukin-6 Gene -573G>C Promoter Polymorphism is Associated with Plasma Fibrinogen Level and Hypertension in Hong Kong Chinese, American Journal of Hypertension. 2005, 18: 186A.

Wong L.Y.F., Cheung B.M.Y., Li C. and Tang F., Temporal Changes in Cytokine Levels in Plasma and Various Peripheral Tissues of Rat After Treatment with Lipopolysaccharide, 9th Medical Research Conference, Faculty of Medicine, The University of Hong Kong. 2004.

Researcher : Wong RWM

Project Title:	Non-cardiac chest pain in Chinese population
Investigator(s):	Wong RWM, Lam SK, Wong BCY
Department:	Medicine
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	12/2003

Abstract:

To study the prevalence, health-seeking behaviour and the natural history of non-cardiac chest pain by a population-based telephone survey in Chinese; to determine the optimal treatment for patients with non-cardiac chest pain by two randomized double-blind placebo-controlled trials.

Project Title:	Non-cardiac chest pain in Chinese population
Investigator(s):	Wong RWM, Lam SK, Wong BCY
Department:	Medicine
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	12/2003

Abstract:

List of Research Outputs

Gu Q., Wang J., Xia H.H.X., Lin M.C., He H., Zou B., Tu S., Yang Y., Liu X.G., Lam S.K., Wong R.W.M., Chan O.O., Yuen R.M.F., Kung H. and Wong B.C.Y., Activation of the Caspase-8/Bid and Bax Pathways in Aspirin-Induced Apoptosis in Gastric Cancer, Carcinogenesis. 2005, 26(3): 541-546.

Gu Q., Xia H.H.X., Wang W., Wang J., Wong R.W.M., Chan O.O., Yuen M.F., Lam S.K., Cheung K.L., Liu X.G. and Wong B.C.Y., Effect of Cyclo-Oxygenase Inhibitors on Helicobacter pylori Susceptibility to Metronidazole and Clarithromycin, Alimentary Pharmacology and Therapeutics. 2004, 20: 675-681.

Huang J., Zheng G., Hunt R.H., Wong R.W.M., Lam S.K., Karlberg J.P.E. and Wong B.C.Y., Do patients with non-ulcer dyspepsia respond differently to Helicobacter pylorieradication treatments from those with peptic ulcer disease? A systemic review, World Journal of Gastroenterology. 2005, 11 (18): 2726-2732.

Hui C.K., Lai K.C., Wong R.W.M., Yuen R.M.F., Ng M.M.T., Chan C.K., Hu H.C., Cheung W.W., Lai C.L. and Wong B.C.Y., Outpatients Undergoing Therapeutic Endoscopic Retrograde Cholangiopancreatography: Six-hour Versus Overnight Observation , Journal of Gastroenterology and Hepatology. 2004, 19: 1163-1168.

Jiang X., Tu S., Cui J., Lin M.C., Xia H.H.X., Wong R.W.M., Chan O.O., Yuen M.F., Jiang S.H., Lam S.K., Kung H., Soh J.W., Weinstein I.B. and Wong B.C.Y., Antisense Targeting Protein Kinase C Alpha and Beta1 Inhibits Gastric Carcinogenesis, Cancer Research. 2004, 64: 5787-5794.

Lui S.L., Wong R.W.M., Ng S.Y., Chan D.T.M., Lai K.N. and Lo W.K., Seroprevalence of Helicobacter pylori in Chinese patients on continuous ambulatory peritoneal dialysis , Nephrology. 2005, 10(1): 21-24.

Tu S., Cui J., Liston P., Jiang X., Xu R., Lin M.C., Zhu Y.B., Zou B., Ng S.M., Jiang S.H., Xia H.H.X., Wong R.W.M., Chan O.O., Yuen R.M.F., Lam S.K., Kung H. and Wong B.C.Y., Gene Therapy for Colon Cancer by Adeno-Associated Viral Vector-Mediated Transfer of Survivin Cys84Ala Mutant, Gastroenterology. 2005, 128: 361-375.

Wang W.H., Huang J., Zheng G., Wong R.W.M., Lam S.K., Karlberg J.P.E., Xia H.H.X., Fass R. and Wong B.C.Y., Is Proton Pump Inhibitor Testing an Effective Approach to Diagnose Gastroesophageal Reflux Disease in Patients With Noncardiac Chest Pain?, Archives of Internal Medicine. 2005, 165: 1222-1228.

Wong B.C.Y., Chan O.O., Wong K.W., Ching C.K., Wong R.W.M., Tam S., Lai K.C., Chan C.K., Yuen R.M.F. and Lam S.K., A pilot study of participation in faecal occult blood testing and screening colonoscopy after health education in Hong Kong, European Journal of Cancer Preview. 2005, 14(2): 181-184.

Wong R.W.M., Lim P. and Wong B.C.Y., Clinical practice pattern of gastroenterologists, primary care physicians, and otolaryngologists for the management of GERD in the Asia-Pacific region: the FAST survey, Journal of Gastroenterology and Hepatology. 2004, 19(Suppl 3): S54-S60.

Wong R.W.M. and Wong B.C.Y., Colorectal Screening: Part II - Sigmoidoscopy, Colonoscopy, Double-Contrast Barium Enema and Virtual Colonoscopy, Medical Progress. 2005, 32(4): 193-197.

Wong R.W.M. and Wong B.C.Y., Constipation - an update, The Hong Kong Medical Diary. 2004, 9(6): 3-6.

Wong R.W.M. and Wong B.C.Y., Definition and diagnosis of gastroesophageal reflux disease, Journal of Gastroenterology and Hepatology. 2004, 19(Suppl 3): S26-S32.

Wong R.W.M., Hui W.M. and Wong B.C.Y., Diagnosis of Barrett's esophagus in the Asian population, Journal of Gastroenterology and Hepatology. 2005, 20(3): 495.

Wong R.W.M., Huang J., Xia H.H.X., Fung F.M.Y., Tong S.M., Cheung K.L., Ho Y.K., Lai K.C., Chan C.K., Chan O.O., Hui C.K., Lam S.K. and Wong B.C.Y., Low-dose rabeprazole, amoxicillin and metronidazole triple therapy for the treatment of Helicobacter pylori infection in Chinese patients , Journal of Gastroenterology and Hepatology. 2005, 20(6): 935-940.

Wong R.W.M., New Diagnostic Tools in GERD, 9th Hong Kong Medical Forum. 2004.

Wong R.W.M., New Diagnostic Tools in GERD, Xian-Hong Kong Medical Forum 2004. 2004.

Wong R.W.M., Lai K.C., Hui W.M., Hu H.C., Huang J., Wong Y.H., Xia H.H.X., Chan O.O., Lam S.K. and Wong B.C.Y., Pathophysiology of Gastroesophageal Reflux Diseases in ChineseRole of Transient Lower Esophageal Sphincter Relaxation and Esophageal Motor Dysfunction, American Journal of Gastroenterology. 2004, 99: 2088-2093.

Wong R.W.M., Hui W.M. and Wong B.C.Y., Reply from authors, Journal of Gastroenterology and Hepatology. 2005, 20(3): 495.

Wong R.W.M., Xiao S.D., HU P.J., Wang W., Gu Q., Huang J., Xia H.H.X., WU S.M., LI C.J., CHEN M.H., CUI Y., Lai K.C., Hu H.C., Chan C.K., Lam S.K. and Wong B.C.Y., Standard treatment for Helicobacter pylori infection is suboptimal in non-ulcer dyspepsia compared to duodenal ulcer in Chinese, Alimentary Pharmacology and Therapeutics. 2005, 21: 73-81.

Xia H.H.X., Yang Y., Lam S.K., Wong R.W.M., Leung S.Y., Yuen S.T., Elia G., Wright N.A. and Wong B.C.Y., Aberrant Epithelial Expression of Trefoil Family Factor 2 and Mucin 6 in Helicobacter pylori infected gastric antrum, incisura, and body and its association with antralisation, Journal of clinical pathology. 2004, 57: 861-866.

Xia H.H.X., Lam S.K., Huang X.R., Wong R.W.M., Leung S.Y., Yuen S.T., Lan H.Y. and Wong B.C.Y., Helicobacter pylori Infection is Associated with Increased Expression of Macrophage Migratory Inhibitory Factor - by Epithelial Cells, T Cells, and Macrophages - in Gastric Mucosa, The Journal of Infectious Diseases. 2004, 190: 293-302.

Yuen R.M.F., Yuan H., Wong D.K.H., Yuen J.C.H., Wong R.W.M., Chan O.O., Wong B.C.Y., Lai K.C. and Lai C.L., Prognostic determinants for chronic hepatitis B in Asians: therapeutic implications., Gut. 2005, online.

Researcher : Wong RWS

List of Research Outputs

Chu M.Y., Wong R.W.S., Ho R., Yeung D., Lau S.K., Kwong E. and Lau W.C.S., Utilisation of the Chinese arthritis impact measurement scales-2 (CAIMS-2): capturing clinical status changes in patients with rheumatoid arthritis (RA), 11th APLAR Bi-annual Congress, Jeju, Korea 11-16 September 2004.

Kim D.L., Wong R.W.S., Jones B.M., Lau W.C.S. and Kim T.Y., Antiperinuclear factor in Chinese: does antiperinuclear factor have the same implication in Chinese and Western populations?, 11th APLAR Bi-annual Congress, Jeju, Korea 11-16 September 2004.

Lok-Chu E.M.Y., Chiu P.K.Y., Wong R.W.S., Tang W.M., Tang W.M. and Lau W.C.S., Translation and validation of arthritis impact measurement scales 2 into Chinese: CAIMS2, Arthritis Care & Research. 2004, 51(1): 20-27.

Mok C.C., Ying K.Y., Tang S.C.W., Leung C.Y., Lee K.W., Ng W.L., Wong R.W.S. and Lau W.C.S., Predictors and outcome of renal flares after successful cyclophosphamide treatment for diffuse proliferative lupus glomerulonephritis. , Arthritis & Rheumatism. 2004, 50: 2559-2568.

Mok C.C., Ying K.Y., Lau W.C.S., Yim C.W., Ng W.L., Wong R.W.S. and Au T.C., Treatment of pure membranous lupus nephropathy with prednisone and azathiporine: an open-label trial, American Journal of Kidney Disease. 2004, 43(2): 269-76.

Mok T.M.Y., Chan E.Y.T., Lo Y., Wong R.W.S. and Lau W.C.S., Antiphospholipid (aPL) antibody profiles in Chinese patients with systemic lupus erythematosus, 11th APLAR Bi-annual Congress, Jeju, Korea 11-16 September 2004.

Mok T.M.Y., Leung P.Y., Lao T.T.H., Lo Y., Chan D.T.M., Wong R.W.S. and Lau W.C.S., Clinical predictors of fetal and maternal outcome in Chinese patients with systemic lupus erythematosus, 11th APLAR Bi-annual Congress, Jeju, Korea 11-16 September 2004.

Mok T.M.Y., Lo Y., Chan D.T.M., Wong R.W.S. and Lau W.C.S., Tuberculosis in systemic lupus erythematosus in an endemic area and the role of isoniazid prophylaxis during corticosteroid therapy. , Journal of rheumatology. 2005, 32(4): 609-615.

To C.H., Mok C.C., Ying K.Y., Ng W.L., Lee K.W., Wong R.W.S. and Lau W.C.S., Effect of the route of CYC administration on its efficacy and toxicities in the treatment of severe lupus nephritis, 11th APLAR Bi-annual Congress, Jeju, Korea 11-16 September 2004.

Wong R.W.S., Loong F., Ooi C.G.C., Tse T.C. and Chim J.C.S., Primary granulocytic sarcoma of the mediastinum, Leukaemia & Lymphoma. 2004, 45(9):1931-3.

Researcher : Wong WM

Project Title:	Non-cardiac chest pain in Chinese population
Investigator(s):	Wong RWM, Lam SK, Wong BCY
Department:	Medicine
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	12/2003

Abstract:

Project Title:	Non-cardiac chest pain in Chinese population
Investigator(s):	Wong RWM, Lam SK, Wong BCY
Department:	Medicine
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	12/2003

Abstract:

List of Research Outputs

Researcher : Wong WS

List of Research Outputs

Mok T.M.Y., Chan E.Y.T., Fong D.Y.T., Leung K.F.S., Wong W.S. and Lau W.C.S., Antiphospholipid Antibody Profiles and Their Clinical Associations in Chinese Patients with Systemic Lupus Erythematosus, The Journal of Rheumatology. 2005, 32 (4): 622-8.

Mok T.M.Y., Leung P.Y., Lao T.T.H., Lo Y., Chan D.T.M., Wong W.S. and Lau W.C.S., Clinical predictors of fetal and maternal outcome in Chinese patients with systemic lupus erythematosus, Annals Of The Rheumatic Diseases. 2004, 63: 1705-1706.

Researcher : Wong Y

List of Research Outputs

Tan K.C.B., Shiu S.W.M., Wong Y. and Tam S., Plasma phospholipid transfer protein activity and subclinical inflammation in type 2 diabetes mellitus, Atherosclerosis. 2005, 178(2): 365-70.

Researcher : Wong YH

List of Research Outputs

Wong R.W.M., Lai K.C., Hui W.M., Hu H.C., Huang J., Wong Y.H., Xia H.H.X., Chan O.O., Lam S.K. and Wong B.C.Y., Pathophysiology of Gastroesophageal Reflux Diseases in ChineseRole of Transient Lower Esophageal Sphincter Relaxation and Esophageal Motor Dysfunction, American Journal of Gastroenterology. 2004, 99: 2088-2093.

Researcher : Wu AYY

List of Research Outputs

Ho J.C.M., Wu A.Y.Y., Lam B., Ooi C.G.C., Khong P.L., Ho P.L., Chan M.M.W., Zhong N.S., Ko K.W., Lam W.K. and Tsang K.W.T., Pentaglobin in steroid-resistant severe acute respiratory syndrome, International Journal of Tuberculosis and Lung Disease. 2004, 8(10): 1173-1179.

Huang F., Ma L., Wu A.Y.Y., Tian L., Chan K.W., Trendell-Smith N.J., Lam A.C., Chan A.K.L., Lo C.K., Chik S.C.C., Ko K.H., To K.W., Kam S.K., Fong L.P., Li X.S., Leung S.Y., Ng M.H., Stott D.I., Liew F.Y. and MacPherson G.G., Systemic autoimmune disease induced by dendritic cells that have captured necrotic but not apoptotic dying cells, Proceedings of the 12th International Congress of Immunology and the 4th Annual Conference of FOCIS, Montreal, Canada, July 18-23, 2004. 2004.

Ren Y., He Q., Fan J.Q., Jones B., Zhou Y., Xie Y., Cheung C.Y., Wu A.Y.Y., Chiu J., Peiris J.S.M. and Tam P.K.H., The use of proteomics in the discovery of serum biomarkers from patients with severe acute respiratory syndrome, Proteomics. 2004, 4: 3477-3484.

Wang J., Law K.W., Ip M.S.M., Wu A.Y.Y., Wong M.K., Lam B., Chow K.M. and Chan M.M.W., Effect of asthma self management programme on asthma morbidity and health care utilization in adult patients admitted to hospital with acute asthma in Hong Kong: A randomized controlled trial, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A91.

Researcher : Wun YT

List of Research Outputs

Chung J.T.N., Wun Y.T. and Lam T.P., Vocational training in Family Medicine: the trainers' perspectives., Wonca World Conference in Orlando, USA. 2004.

Researcher : Xia HHX

Project Title:	Topographic association of helicobacter pylori infection with apoptosis and cell proliferation in the human stomach: roles of H. pylori-induced antralization in the pathogenesis of gastric cancer
Investigator(s):	Xia HHX, Lam SK, Wong BCY
Department:	Medicine
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	10/2001

Abstract:

To elucidate the carcinogenesis of H.pylori infection at the molecular and cellular levels.

Project Title:	Homeobox genes in gastric carcinogenesis: an in vivo and in vitro study
Investigator(s):	Xia HHX, Wong BCY
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2003

Abstract:

To investigate the expression of gastric-related homeobox genes in human normal, precancerous and cancerous gastric tissues in vivo, and in non-malignant and malignant gastric cancer cell lines in vitro; to determine the effect of gastric-related homeobox genes on the secretion of gastric endocrine hormones.

Project Title:	Molecular and genetic mechanisms of helicobacter pylori-induced antralization in gastric carcinogenesis
Investigator(s):	Xia HHX, Wong BCY
Department:	Medicine
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	12/2003

Abstract:

To explore the molecular and genetic mechanisms of H. pylori-induced antralization in gastric carcinogenesis; to identify the initial physiological changes in the process of H. pylori-induced antralization (the presence of antral-type mucosa) and precancerous lesions at the gastric incisura; to determine whether these physiological changes can be used as biomarkers for H. pylori-induced antralization and precancerous lesions at the gastric incisura; to determine whether the process of H. pylori-induced antralization and precancerous lesions at the gastric incisura involves a mutation or other genetic changes in homeobox genes.

Project Title:	Molecular and genetic mechanisms of helicobacter pylori-induced antralization in gastric carcinogenesis
Investigator(s):	Xia HHX, Wong BCY
Department:	Medicine
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	12/2003

Abstract:

Project Title:	Role of cyclooxygenase in helicobacter pylori-induced gastric carcinogenesis
Investigator(s):	Xia HHX, Wong BCY
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2004

Abstract:

To reveal the precise mechanism of COX and interrelationship between COX and H. pylori infection in the pathogenesis of gastric cancer; to provide insights into whether specific targets can be dealth with by new drugs, or a combination of drugs on different cellular targets to potentiate the chemoprevention effects; to develop effective strategies in the prevention of gastric cancer, for which no active agent or drug is available at present.

Project Title:	Role of cyclooxygenase in helicobacter pylori-induced gastric carcinogenesis
Investigator(s):	Xia HHX, Wong BCY, Feng Z.H.
Department:	Medicine
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	01/2005

Abstract:

To determine the differences in gastric epithelial proliferation and apoptosis as well as in the incidence of gastric precancerous and cancerous lesions between COX deficient mice and wild-type mice after long-term infection with H. pylori; to determine the effects of NSAIDs and specific COX2 inhibitors on gastric proliferation and apoptosis, and their potential role in the prevention of gastric precancerous and cancerous lesions in H. pylori infected Mongolian gerbils.

Project Title:	Role of cyclooxygenase in helicobacter pylori-induced gastric carcinogenesis
Investigator(s):	Xia HHX
Department:	Medicine
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

Refer to hard copy

Project Title:	Role of macrophage migration inhibitory factor in Helicobacter pylori-induced gastric carcinogenesis
Investigator(s):	Xia HHX, Wong BCY
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2005

Abstract:

Refer to hard copy

List of Research Outputs

Ding H., Wand B.E., Jia J.D., Xia H.H.X., Wong B.C.Y., Zhao C.H. and Xu Y.L., Effects of octreotide on expression of L-type voltage-operated calcium channels and on intracellular Ca2+ in activated hepatic stellate cells, Chinese Medical Journal. 2004, 117(6): 913-916.

Fawcett J.P., Barbezat G.O., Poulton R., Milne B.J., Xia H.H.X. and Talley N.J., Trends in the prevalence of peptic ulcer disease and Helicobacter pylori Helicobacter pylori serology in a birth cohort of New Zealanders from age 11 to 26., World Journal Gastroenterology . 2005, 11: 3273-3276.

Gu Q., Wang J., Xia H.H.X., Lin M.C., He H., Zou B., Tu S., Yang Y., Liu X.G., Lam S.K., Wong R.W.M., Chan O.O., Yuen R.M.F., Kung H. and Wong B.C.Y., Activation of the Caspase-8/Bid and Bax Pathways in Aspirin-Induced Apoptosis in Gastric Cancer, Carcinogenesis. 2005, 26(3): 541-546.

Gu Q., Xia H.H.X., Wang W., Wang J., Wong R.W.M., Chan O.O., Yuen M.F., Lam S.K., Cheung K.L., Liu X.G. and Wong B.C.Y., Effect of Cyclo-Oxygenase Inhibitors on Helicobacter pylori Susceptibility to Metronidazole and Clarithromycin, Alimentary Pharmacology and Therapeutics. 2004, 20: 675-681.

Jiang X., Tu S., Cui J., Lin M.C., Xia H.H.X., Wong R.W.M., Chan O.O., Yuen M.F., Jiang S.H., Lam S.K., Kung H., Soh J.W., Weinstein I.B. and Wong B.C.Y., Antisense Targeting Protein Kinase C Alpha and Beta1 Inhibits Gastric Carcinogenesis, Cancer Research. 2004, 64: 5787-5794.

Li C., Xia B., Xia H.H.X., Li J. and Yang Y., No association of polymorphisms of lymphotoxin A NcoI, AspHI with helicobacter pylori infection in gastroduodenal diseases., Acta Wuhan University (Medicine) . 2004, 25: 245-248.

Li C., Xia B., Yang Y., Li J. and Xia H.H.X., TNF gene polymorphisms and Helicobacter pylori infection in gastric carcinogenesis in Chinese population., American Journal of Gastroenterology. 2005, 100: 290-294.

Li C., Xia B., Yang Y., Li J. and Xia H.H.X., TNF gene polymorphisms and Helicobacter pylori infection in gastric carcinogenesis in Chinese population., J Gastroenterol Hepatol . 2004, A366.

Li G., Xia H.H.X., Chen M.H., Chan O.O., Cho C.H., Lam S.K., Berg D., Feng Z., Langenbach R. and Wong B.C.Y., Effects of Cyclooxygenase-1 and -2 Gene Disruption on Helicobacter pylori-Induced Inflammation, Apoptosis and Proliferation, Journal of Gastroenterology and Hepatology. 2004, 19(Suppl.): A299.

Li G.Q. and Xia H.H.X., Eradication therapy of Helicobacter pylori infection, and causes of and preventive strategies for treatment failure., 幽?螺杆菌根除治?、治?失?的原因及其?策, Chinese Journal of Gastroenterology. 胃?病?, 2005, 10: 37-43.

Ren Z., Borody T., Pang G., Dunkley M., Clancy R., Xia H.H.X., Chu K.M., Wong J. and Wong B.C.Y., Evaluation of anti-Helicobacter pylori IgG2 antibody for the diagnosis of Helicobacter pylori infection in Western and Chinese populations, Alimentary Pharmacology & Therapeutics. 2005, 21: 83-89.

Tu S., Cui J., Liston P., Jiang X., Xu R., Lin M.C., Zhu Y.B., Zou B., Ng S.M., Jiang S.H., Xia H.H.X., Wong R.W.M., Chan O.O., Yuen R.M.F., Lam S.K., Kung H. and Wong B.C.Y., Gene Therapy for Colon Cancer by Adeno-Associated Viral Vector-Mediated Transfer of Survivin Cys84Ala Mutant, Gastroenterology. 2005, 128: 361-375.

Wang J., Zou B., Gu Q., Jiang B., Zhuang Z., Xia H.H.X., Lin M.C., Lam S.K., Kung H. and Wong B.C.Y., Down-regulation of XAF1 expression by its interacting protein FHL2 via p53-mediated transcription regulation, Gastroenterology. 2005, 128(4 Suppl 2): A105.

Wang J., Gu Q., He H., Jiang B., Zhuang Z., Xia H.H.X., Lin M.C., Lam S.K., Kung H. and Wong B.C.Y., Down-regulation of XIAP associated factor 1 (XAF1) through Hsf-1 binding in the promoter region, Gastroenterology. 2005, 128(4 Suppl 2): A105.

Wang W.H., Huang J., Zheng G., Wong R.W.M., Lam S.K., Karlberg J.P.E., Xia H.H.X., Fass R. and Wong B.C.Y., Is Proton Pump Inhibitor Testing an Effective Approach to Diagnose Gastroesophageal Reflux Disease in Patients With Noncardiac Chest Pain?, Archives of Internal Medicine. 2005, 165: 1222-1228.

Wong B.C.Y. and Xia H.H.X., Prevention of gastric cancer by Helicobacter pylori eradication, In: Sugano K, Helicobacter pylori-associated Gastric Cander - Evidence of its Carcinogenesis. Japan, Igaku-Shoin Ltd, 2004, 69-72.

Wong R.W.M., Huang J., Xia H.H.X., Fung F.M.Y., Tong S.M., Cheung K.L., Ho Y.K., Lai K.C., Chan C.K., Chan O.O., Hui C.K., Lam S.K. and Wong B.C.Y., Low-dose rabeprazole, amoxicillin and metronidazole triple therapy for the treatment of Helicobacter pylori infection in Chinese patients , Journal of Gastroenterology and Hepatology. 2005, 20(6): 935-940.

Wong R.W.M., Lai K.C., Hui W.M., Hu H.C., Huang J., Wong Y.H., Xia H.H.X., Chan O.O., Lam S.K. and Wong B.C.Y., Pathophysiology of Gastroesophageal Reflux Diseases in ChineseRole of Transient Lower Esophageal Sphincter Relaxation and Esophageal Motor Dysfunction, American Journal of Gastroenterology. 2004, 99: 2088-2093.

Wong R.W.M., Xiao S.D., HU P.J., Wang W., Gu Q., Huang J., Xia H.H.X., WU S.M., LI C.J., CHEN M.H., CUI Y., Lai K.C., Hu H.C., Chan C.K., Lam S.K. and Wong B.C.Y., Standard treatment for Helicobacter pylori infection is suboptimal in non-ulcer dyspepsia compared to duodenal ulcer in Chinese, Alimentary Pharmacology and Therapeutics. 2005, 21: 73-81.

Wong W.M., Lai K.C., Lam K.F., Hui W.M., Huang J.Q., Xia H.H.X., Hu H.C., Lam C.L.K., Chan C.K., Lam S.K. and Wong B.C.Y., Onset and disappearance of Reflux Symptoms in a Chinese population: a one-year follow-up study, Alimentary Pharmacology and Therapeutics. 2004, 20: 803-812.

Xia B., Xia H.H.X., Lam S.K., Chan O.O., Lai K.C., Hu H.C. and Wong B.C.Y., Trends in prevalence of peptic ulcer disease and Helicobacter pylori infection and frequency of NSAID intake in general practitioner-referred dyspeptic patients over 6 years in Hong Kong, Gastroenterology. 2005, 128(4 Suppl 2): A230.

Xia H.H.X., Yang Y., Lam S.K., Wong R.W.M., Leung S.Y., Yuen S.T., Elia G., Wright N.A. and Wong B.C.Y., Aberrant Epithelial Expression of Trefoil Family Factor 2 and Mucin 6 in Helicobacter pylori infected gastric antrum, incisura, and body and its association with antralisation, Journal of clinical pathology. 2004, 57: 861-866.

Xia H.H.X., Wong B.C.Y., Zhang G.S., Yang Y., Wyatt J.M., Adams S., Cheung K., Lam S.K. and Talley N.J., Antralization of Gastric Incisura is Topographically Associated with Increased Gastric Epithelial Apoptosis and Proliferation, but not with CagA Seropositivity, Journal of Gastroenterology and Hepatology. 2004, 19: 1257-1263.

Xia H.H.X., Associate Editor-in-Chief, World Journal of Gastroenterology. 2004.

Xia H.H.X., Li G., Chen M.H., Chan O.O., Cho C.H., Lam S.K., Berg D., Feng Z., Langenbach R. and Wong B.C.Y., Cyclooxygenase-1 and -2 Gene Disruption Potentiate TH1 Polarization in Response to Helicobacter pylori, Journal of Gastroenterology and Hepatology. 2004, 19(Suppl.): A366.

Xia H.H.X., Editorial Board, Journal of Gastroenterology and Hepatology. 2005.

Xia H.H.X., Zhang S., Lam S.K., Lin M.C., Kung H. and Wong B.C.Y., Expression of Macrophage Migration Inhibitory Factor in Esophageal Squamous Cell Carcinoma and Effects of Bile Acids and NSAIDs, Carcinogenesis. 2005, 26(1): 11-15.

Xia H.H.X., Lam S.K., Chan O.O., Lin M.C., Kung H., Ogura K., Berg D.E. and Wong B.C.Y., Macrophage Migration Inhibitory Factor Stimulated by Helicobacter pylori Increases Proliferation of Gastric Epithelial Cells, World Journal of Gastroenterology. 2005, 11(13): 1946-1950.

Xia H.H.X., Reinfection of Helicobacter pylori after successful eradication, The 2nd Beijing International Digestive Disease Forum, Beijing 24-26 June 2005. 2005.

Xia H.H.X., Lam S.K., Huang X.R., Wong R.W.M., Leung S.Y., Yuen S.T., Lan H.Y. and Wong B.C.Y., Helicobacter pylori Infection is Associated with Increased Expression of Macrophage Migratory Inhibitory Factor - by Epithelial Cells, T Cells, and Macrophages - in Gastric Mucosa, The Journal of Infectious Diseases. 2004, 190: 293-302.

Zhu S., Xia H.H.X., Lam S.K., Yu L., Yang Y., Sun Y., Wang J., Chan O.O. and Wong B.C.Y., Alterations of gastric homeoprotein expression in H. Pylori infection and/or intestinal metaplasia, Gastroenterology. 2005, 128(4 Suppl 2): A598.

Zhuang Z., Tsao G.S.W., Xia H.H.X., He H., Chan O.O., Lam S.K. and Wong B.C.Y., COX-2 inhibition induces apoptosis in human esophageal epithelial cells: implication for chemoprevention, Gastroenterology. 2005, 128(4 Suppl 2): A299.

Researcher : Xu A

Project Title:	Adiponectin as a novel hormone for the treatment of diabetes and obesity-related metabolic syndromes
Investigator(s):	Xu A, Lam KSL
Department:	Medicine
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2003

Abstract:

To explore the physiological functions and the clinical applications of adiponectin.

Project Title:	Hepatocytes as a major therapeutic target for the anti-diabetic and anti-inflammatory hormone adiponectin
Investigator(s):	Xu A, Lam KSL
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2004

Abstract:

To define the roles of two recently identified adiponectin receptors and several intracellular signaling pathways (AMP-activated protein kinase, P38 MAP kinase and PPAR_[alpha]) in mediating the multiple biological actions of adiponectin in hepatocytes; to investigate how phosphorylation modulates the activities of adiponectin receptors; to identify the membrane-proximal downstream signaling molecules of adiponectin receptors in hepatocytes.

Project Title:	An adipokine- and cytokine-based antibody biochips for early diagnosis, risk detection and therapeutic monitoring of cardiovascular diseases and diabetes
Investigator(s):	Xu A, Lam KSL, Zhang W.W.
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	09/2004

Abstract:

To generate an antibody chips that can simultaneously detect multiple adipolines, cytolines and acute phase proteins in qualitative and quantitative ways.

Project Title:	Characterization of the receptor and postreceptor events that underlie the anti-atherogenic and anti-diabetic actions of adiponectin
Investigator(s):	Xu A, Lam KSL
Department:	Medicine
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	01/2005

Abstract:

The proposal seeks to address the following three questions: (1) how does adiponectin activate its receptors? (2) what are the membrane proximal down-stream signaling events of adiponectin receptors? how does adiponectin exert its anti-atherogenic actions via macrophage cells?

Project Title:	Characterization of the receptor and postreceptor events that underlie the anti-atherogenic and anti-diabetic actions of adiponectin
Investigator(s):	Xu A
Department:	Medicine
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

Refer to hard copy

Project Title:	Structural and functional characterization of angiopoietin-like protein 4 (ANGPTL4), a novel hormone involved in glucose homeostasis and insulin sensitivity
Investigator(s):	Xu A, Lam KSL
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2005

Abstract:

Refer hard copy

List of Research Outputs

Chan K.W., Xu A., Hoo R.L.C., Tan K.C.B., Zhang J., Lam C.W. and Lam K.S.L., Selective Reduction of the High Molecular Weight Form of Adiponectin by Testosterone: A Potential Mechanism That Underlies the Sexual Dimorphism of Adiponectin Oligomeric Distribution, The Endocrine Society’s 87th Annual Meeting, June 4-7, 2005, San Diego, USA. 2005.

Chan K.W., Xu A., Hoo R.L.C., Lam C.W. and Lam K.S.L., Sexual dimorphism of adiponectin: Why do men have higher risk to diabetes and atherosclerosis than women?, 10th Medical Research Conference, The University of Hong Kong. 19-20 Feb 2005. Endocrinology 24.

Chen B., Xu A., Lam C.W., Hoo R.L.C. and Lam K.S.L., Adenovirus-mediated expression of adiponectin alleviates liver fibrosis and induces apoptosis of activated hepatic stellate cells, 10th Medical Research Conference, The University of Hong Kong. 19-20 Feb 2005. Endocrinology 23.

Ding X., Saxena N.K., Lin S., Xu A., Srinivasan S. and Anania F.A., The Roles Of Leptin And Adiponectin: A Novel Paradigm In Adipocytokine Regulation Of Liver Fibrosis And Stellate Cell Biology, American Journal Of Pathology. The American Society for Investigative Pathology, 2005, 166: 1655-1669.

Hoo R.L.C., Xu A., Lam C.W., Chen B., Carling D. and Lam K.S.L., Adenovirus-mediated expression of constitutively active AMP-activated protein kinase alleviates diabetes in db/db diabetic mice, 10th Medical Research Conference, The University of Hong Kong. 19-20 Feb 2005. Endocrinology 25.

Lam K.S.L., Dan Q., Xu A., Shen J., Cheng K.Y. and Xu J., Adiponectin stimulates the production o fmaganese superoxide dismutase (SOD2) in human aortic smooth muscle cells, 12th International Congress of Endocrinology, Aug 31 – Sep 4, 2004, Lisbon, Portugal. 2004, A442(1242).

Lam K.S.L., Xu A., Tan K.C.B., Wang Y., Dan Q., Chung S.K. and Chung S.S.M., Inflammation and diabetic atherosclerosis: New players in the field, Int Atherosclerosis Society 2005 Commentaries (Epub). 2005.

Lam K.S.L., Xu A., Tan K.C.B., Wong L.C., Tiu S.C. and Tam S., Serum adiponectin is reduced in acromegaly and normalized after correction of growth hormone excess, Journal of Clinical and Endocrinological Metabablism. 2004, 89(11): 5448-53.

Tan K.C.B., Xu A., Chow W.S., Ai W.H.G., Tam S. and Lam K.S.L., Hypoadiponectinemia is associated with impaired endothelium-dependent vasodilatation, Journal of Clinical and Endocrinological Metabolism. 2004, 89(2): 765-9.

Tso A.W.K., Wat N.M.S., Xu A., Sham P.C., Rong R., Cheng K.Y., Fong H.Y., Janus E.D. and Lam K.S.L., The adiponectin gene G276T polymorphism is a risk factor for the development of the metabolic syndrome over a period of 5 years in southern Chinese, 12th International Congress of Endocrinology, Aug 31 – Sep 4, 2004, Lisbon, Portugal. 2004, 318 P949.

Wang Y., Lam K.S.L., Xu J., Gang L., Xu L.Y., Cooper G.J. and Xu A., Adiponectin Inhibits Cell Proliferation by Interacting with Several Growth Factors in an Oligomerization-dependent Manner, The Journal of Biological Chemistry. The American Society for Biochemistry and Molecular Biology, 2005, 280: 18341-18347.

Wang Y., Lam K.S.L., Xu J.Y., Lu G., Xu L.Y., Cooper G.J. and Xu A., Adiponectin inhibits cell proliferation by interacting with several growth factors in oligomerization-dependent manner , Journal of Biological Chemistry. 2005, 280(18): 18341-7.

Wang Y., Lu G., Wong W.P.S., Vliegenthart J.F.G., Gerwig G.J., Lam K.S.L., Cooper G.J. and Xu A., Proteomic and Functional Characterizaion of Endogenous Adiponectin Purified from Fetal Bovine Serum, Proteomics. 2004, 4: 3933-3942.

Wang Y., Lu G., Wong W.P., Vliegenthart J.F., Gerwig G.J., Lam K.S.L., Cooper G.J. and Xu A., Proteomic and functional characterization of endogenous adiponectin purified from fetal bovine serium, Proteomics. 2004, 4(12): 3933-42.

Wat N.M.S., Tso A.W.K., Xu A., Sham P.C., Rong R., Cheng K.Y., Fong H.Y., Janus E.D. and Lam K.S.L., The adiponectin gene T45G polymorphism is associated with central obesity and persistent glucose intolerance in high-risk Chinese subjects over 5 years, 12th International Congress of Endocrinology, Aug 31 – Sep 4, 2004, Lisbon, Portugal. 2004.

Xu A., Hoo R.L.C., Hoo R.L.C., Lam C.W., Chen B. and Lam K.S.L., Adenovirus-Mediated Expression of Adiponectin Alleviates Endothelial Dysfunction and Oxidative Stress Associated with db/db Diabetic Mice, The Endocrine Society’s 87th Annual Meeting, June 4-7, 2005, San Diego, USA. 2005.

Xu A., Wang Y., Cooper G. and Lam K.S.L., Angiopietin-like protein 4 is a negative regulator of adipogenesis in 3T3-L1 cells, 12th International Congress of Endocrinology, Aug 31 – Sep 4, 2004, Lisbon, Portugal. 2004, 318 P947.

Xu A., Chan K.W., Wang Y., Zhang J., Hoo R.L.C., Xu J., Chow W.S. and Lam K.S.L., Angiopoietin-like Protein 4 Decreases Blood Glucose and Improves Glucose Tolerance but Induces Hyperlipidemia and Hepatic Steatosis in Mice, Proceedings of the National Academy of Sciences of the United States of America. 2005, 102: 6086-6091.

Xu A., Lam M.C., Chan K.W., Wang Y., Zhang J.C.L., Xu J., Chen B., Chow W.S., Tso A.W. and Lam K.S.L., Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice, Proc Natl Academic Science USA. 2005, 102(17): 6086-91.

Xu A., Lam C.W., Chan K.W., Zhang J., Hoo R.L.C., Xu J., Chen B. and Lam K.S.L., Angiopoietin-like protein 4 is a novel metabolic hormone with therapeutic potentials for hyperglycemia and insulin resistance, 10th Medical Research Conference, The University of Hong Kong. 19-20 Feb 2005. Endocrinology 22.

Xu A., Wong L.C., Wang Y., Xu J., Cooper G.J. and Lam K.S.L., Chronic treatment with growth hormone stimulates adiponectin gene expression in 3T3-L1 adipocytes, FEBS Letters. 2004, 572(1-3): 129-34.

Xu A., Chan K.W., Hoo R.L.C., Wang Y., Zhang J., Chen B., Cynthia T., Cooper G.J.S. and Lam K.S.L., Testosterone Selectively Reduces the High Molecular Weight Form of Adiponectin by Inhibiting Its Secretion from Adipocytes, The Journal of Biological Chemistry. 2005, 280: 18073-18080.

Xu A., Chan K.W., Hoo R.L.C., Wang Y., Tan K.C.B., Zhang J.C.L., Chen B., Lam M.C., Tse C., Cooper G.J. and Lam K.S.L., Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes, J Biol Chem. 2005, 280(18): 18073-80.

Xu J., Wat N.M.S., Xu A., Cheng K.Y., Sham P.C., Janus E.D. and Lam K.S.L., The G/G Genotype of the -420 C→G Polymorphism in the Resistin Gene Promoter Is Associated with Post-Challenge Glycaemia in Southern Chinese, The Endocrine Society’s 87th Annual Meeting, June 4-7, 2005, San Diego, USA. 2005.

Xu J., Wat N.M.S., Xu A., Cheng K.Y., Sham P.C., Janus E.D. and Lam K.S.L., The G/G genotype of the ->G polymorphism in the resistin gene promoter is associated with post-challenge glycaemia in Southern Chinese, 10th Medical Research Conference, The University of Hong Kong. 19-20 Feb 2005. Endocrinology 26.

Researcher : Xu J

Project Title:	Search for susceptibility gene loci for maturity-onset diabetes of the young in Southern Chinese
Investigator(s):	Xu J, Lam KSL, Sham PC
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Abstract:

To further study the extended MODYX families recruited from our previous project and screen for MODY loci in Southern Chinese, starting with MODY loci reported in other populations; to investigate whether there is overlap between MODY loci and reported T2DM loci in Chinese, based on studies with predilection of early onset T2DM diagnosed before 40 years of age.

List of Research Outputs

Lam K.S.L., Dan Q., Xu A., Shen J., Cheng K.Y. and Xu J., Adiponectin stimulates the production o fmaganese superoxide dismutase (SOD2) in human aortic smooth muscle cells, 12th International Congress of Endocrinology, Aug 31 – Sep 4, 2004, Lisbon, Portugal. 2004, A442(1242).

Wang Y., Lam K.S.L., Xu J., Gang L., Xu L.Y., Cooper G.J. and Xu A., Adiponectin Inhibits Cell Proliferation by Interacting with Several Growth Factors in an Oligomerization-dependent Manner, The Journal of Biological Chemistry. The American Society for Biochemistry and Molecular Biology, 2005, 280: 18341-18347.

Xu A., Chan K.W., Wang Y., Zhang J., Hoo R.L.C., Xu J., Chow W.S. and Lam K.S.L., Angiopoietin-like Protein 4 Decreases Blood Glucose and Improves Glucose Tolerance but Induces Hyperlipidemia and Hepatic Steatosis in Mice, Proceedings of the National Academy of Sciences of the United States of America. 2005, 102: 6086-6091.

Xu A., Lam M.C., Chan K.W., Wang Y., Zhang J.C.L., Xu J., Chen B., Chow W.S., Tso A.W. and Lam K.S.L., Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice, Proc Natl Academic Science USA. 2005, 102(17): 6086-91.

Xu A., Lam C.W., Chan K.W., Zhang J., Hoo R.L.C., Xu J., Chen B. and Lam K.S.L., Angiopoietin-like protein 4 is a novel metabolic hormone with therapeutic potentials for hyperglycemia and insulin resistance, 10th Medical Research Conference, The University of Hong Kong. 19-20 Feb 2005. Endocrinology 22.

Xu A., Wong L.C., Wang Y., Xu J., Cooper G.J. and Lam K.S.L., Chronic treatment with growth hormone stimulates adiponectin gene expression in 3T3-L1 adipocytes, FEBS Letters. 2004, 572(1-3): 129-34.

Xu J., Dan Q., Chan V.N.Y., Wat N.M.S., Tam S., Tiu S.C., Lee K.F., Siu S.C., Tsang M.W., Fung L.M., Chan K.W. and Lam K.S.L., Genetic and Clinical Characteristics of Maturity-onset Diabetes of the Young in Chinese Patients, European Journal of Human Genetics. 2005, 13: 422-427.

Xu J., Wat N.M.S., Xu A., Cheng K.Y., Sham P.C., Janus E.D. and Lam K.S.L., The G/G Genotype of the -420 C→G Polymorphism in the Resistin Gene Promoter Is Associated with Post-Challenge Glycaemia in Southern Chinese, The Endocrine Society’s 87th Annual Meeting, June 4-7, 2005, San Diego, USA. 2005.

Xu J., Wat N.M.S., Xu A., Cheng K.Y., Sham P.C., Janus E.D. and Lam K.S.L., The G/G genotype of the ->G polymorphism in the resistin gene promoter is associated with post-challenge glycaemia in Southern Chinese, 10th Medical Research Conference, The University of Hong Kong. 19-20 Feb 2005. Endocrinology 26.

Researcher : Yam IYL

List of Research Outputs

Chan V.N.Y., Yip B., Yam I.Y.L., Au P., Lin C.K., Wong V.C.N. and Chan T.K., Carrier incidence for spinal muscular atrophy in southern Chinese, Journal of Neurology. 2004, 251: 1089-1093.

Chan V.N.Y., Yam I.Y.L., Yeung W.S.B., Ng E.H.Y., Ho P.C. and Chan T.K., Preimplantation diagnosis of homozygous alpha° thalassemia, Xth Congress of the International Society of Hematology, Asian Pacific Division, Nagoya, Japan, September. 2004.

Researcher : Yam LYC

List of Research Outputs

Lam B., Sam K., Mok W.Y.W., Lam J.C., Yam L.Y.C., Lam W.K. and Ip M.S.M., A randomized study of three non-surgical treatment options in mild to moderate obstructive sleep apnea, American Thoracic Society International Conference, San Diego, USA. May 2005. Proceedings of the American Thoracic Society. 2005, p.A303.

Researcher : Yan CPK

List of Research Outputs

Ho J.C.M., Ho S.P., Chan M.M.W., Mak J.C.W., Ip M.S.M., Ko K.W., Yan C.P.K., Wong M.P., Tsang K.W.T. and Lam W.K., Non-small cell lung cancer in Chinese is associated with disturbance in systemic antioxidant profiles, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December, 2004. Respirology. 2004, 9 (Supp): A114.

Kwok P.W., Leung Y.H., Sun J.Z., Yan C.P.K., Ooi C.G.C., Ho P.L., Ho J.C.M., Tipoe G.L., Lam W.K. and Tsang K.W.T., The Effects of Gelomyrtol Forte on Human Ciliary Beat Frequency in vitro, Abstract Book of the 10th Medical Research Conference, University Department of Medicine, The University of Hong Kong, 19-20 February. 2005, page 65.

Kwok R., Leung Y.H., Sun J.Z., Yan C.P.K., Ooi C.G.C., Ho P.L., Ho J.C.M., Tipoe G.L., Lam W.K. and Tsang K.W.T., The effects of gelomyrtol forte on human ciliary beat frequency in vitro, Respirology. 2004, 9 (Suppl): A162 (290).

Mak J.C.W., Ho S.P., Leung Y.H., Ho P.L., Ooi C.G.C., Yan C.P.K., Ko K.W., Ip M.S.M., Lam W.K. and Tsang K.W.T., Elevated levels of transforming growth factor- beta 1 in serum of patients with stable bronchiectasis, 9th Congress of Asian Pacific Society of Respirology, Hong Kong, December 2004. Respirology. 2004, 9 (Supp): A134.

Tsang K.W.T., Tipoe G.L., Sun J.Z., Tan K.C.B., Leung Y.H., Yan C.P.K., Ko K.W., Ooi C.G.C., Ho J.C.M. and Lam W.K., Clinical value of ciliary assessment in bronchiectasis, Lung. 2005, 183(2): 73-86.

Researcher : Yang Y

List of Research Outputs

Gu Q., Wang J., Xia H.H.X., Lin M.C., He H., Zou B., Tu S., Yang Y., Liu X.G., Lam S.K., Wong R.W.M., Chan O.O., Yuen R.M.F., Kung H. and Wong B.C.Y., Activation of the Caspase-8/Bid and Bax Pathways in Aspirin-Induced Apoptosis in Gastric Cancer, Carcinogenesis. 2005, 26(3): 541-546.

Xia H.H.X., Yang Y., Lam S.K., Wong R.W.M., Leung S.Y., Yuen S.T., Elia G., Wright N.A. and Wong B.C.Y., Aberrant Epithelial Expression of Trefoil Family Factor 2 and Mucin 6 in Helicobacter pylori infected gastric antrum, incisura, and body and its association with antralisation, Journal of clinical pathology. 2004, 57: 861-866.

Xia H.H.X., Wong B.C.Y., Zhang G.S., Yang Y., Wyatt J.M., Adams S., Cheung K., Lam S.K. and Talley N.J., Antralization of Gastric Incisura is Topographically Associated with Increased Gastric Epithelial Apoptosis and Proliferation, but not with CagA Seropositivity, Journal of Gastroenterology and Hepatology. 2004, 19: 1257-1263.

Zhu S., Xia H.H.X., Lam S.K., Yu L., Yang Y., Sun Y., Wang J., Chan O.O. and Wong B.C.Y., Alterations of gastric homeoprotein expression in H. Pylori infection and/or intestinal metaplasia, Gastroenterology. 2005, 128(4 Suppl 2): A598.

Researcher : Yang Y

List of Research Outputs

Researcher : Yeung CK

List of Research Outputs

Yeung C.K., Ma S.Y., Chan H.H.L., Trendell-Smith N.J. and Au W.Y., Primary CD30+ve Cutaneous T-cell Lymphoma Associated with Chronic Burn Injury in a Patient with Longstanding Psoriasis, American Journal of Dermatopathology. 2004, 26(5): 394-396.

Researcher : Yeung JSL

List of Research Outputs

Lau W.C.S., Yeung J.S.L., Chan W.K. and Ren Y., Diminished macrophage (Mac) clearance of apoptotic polymorphonuclear cells (PMN) in patients with rheumatoid arthritis (RA), 11th APLAR Bi-annual Congress, Jeju, Korea 11-16 Septemer 2004.

Researcher : Yew WW

List of Research Outputs

Mak J.C.W., Ho J.C.M., Ho S.P., Yu W.C., Yew W.W., Tsang K.W.T., Lam W.K., Ip M.S.M. and Chan M.M.W., Increased oxidative stress and altered antioxidant status in Chinese patients with COPD, European Respiratory Journal. 2004, 24: Suppl 48: 62s.

Researcher : Young RTT

List of Research Outputs

Lai C.L. and Young R.T.T., Co-chaired the session of “Interpreting Abnormal Laboratory Findings” , 9th Hong Kong Medical Forum. 2004.

Researcher : Yu L

List of Research Outputs

Zhu S., Xia H.H.X., Lam S.K., Yu L., Yang Y., Sun Y., Wang J., Chan O.O. and Wong B.C.Y., Alterations of gastric homeoprotein expression in H. Pylori infection and/or intestinal metaplasia, Gastroenterology. 2005, 128(4 Suppl 2): A598.

Researcher : Yuan H

List of Research Outputs

Wong D.K.H., Yuen R.M.F., Tse E.W.C., Yuan H., Sum S.M., Hui C.K. and Lai C.L., Detection of Intrahepatic Hepatitis B Virus DNA and Correlation with Hepatic Necroinflammation and Fibrosis, Journal of Clinical Microbiology. 2004, 42: 3920-3924.

Wong D.K.H., Yuen R.M.F., Yuan H., Sum S.M., Hui C.K., Hall J. and Lai C.L., Quantitation of Covalently Closed Circular Hepatitis B Virus DNA in Chronic Hepatitis B Patients, Hepatology. 2004, 40: 727-737.

Yuan H., Yuen R.M.F., Wong D.K.H., Sum S.M. and Lai C.L., Clinical Evaluation of the Digene Hybrid Capture II Test and the COBAS AMPLICOR Monitor Test for Determination of Hepatitis B Virus DNA Levels, Journal of Clinical Microbiology. 2004, 42: 3513-3517.

Yuan H., Yuen R.M.F., Wong D.K.H., Sum S.M., Doutreloigne J., Sablon E. and Lai C.L., Determinants for the Occurrence of Acute Exacerbation of Hepatitis B Virus Infection in Chinese Patients after HBeAg Seroclearance , Journal of Clinical Microbiology. 2005, 43: 1594-1599.

Yuen M.F., Ng I.O.L., Fan S.T., Yuan H., Wong D.K.H., Yuen J.C.H., Sum S.M., Chan O.O. and Lai C.L., Significance of HBV DNA levels in liver histology of HBeAg and anti-HBe positive patients with chronic hepatitis B, American Journal of Gastroenterology. 2004, 99(10): 2032-2037.

Yuen R.M.F., Wong D.K.H., Sum S.M., Yuan H., Yuen J.C.H., Chan O.O., Wong B.C.Y. and Lai C.L., Effect of lamivudine therapy on the serum covalently closed circular DNA of chronic hepatitis B infection., 55th Annual Meeting of the American Association for the Study of Liver Diseases, Boston, USA 29 Oct-2 Nov 2004 (Published in Hepatology). 2004, 40(4): 671A.

Yuen R.M.F., Wong D.K.H., Sum S.M., Yuan H., Yuen J.C.H., Chan O.O., Wong B.C.Y. and Lai C.L., Effect of lamivudine therapy on the serum covalently closed-circular (ccc) DNA of chronic hepatitis B infection., American Journal of Gastroenterology. 2005, 100(5): 1099-103.

Yuen R.M.F., Sablon E., Tanaka Y., Kato T., Mizokami M., Doutreloigne J., Yuan H., Sum S.M. and Lai C.L., Epidemiological study of hepatitis B virus genotypes, core promoter and precore mutations of chronic hepatitis B infection in Hong Kong. , Journal of hepatology : the journal of the European Association for the Study of the Liver. 2004, 41(1): 119-25.

Yuen R.M.F., Wong D.K.H., Yuan H., Sum S.M. and Lai C.L., HBsAg seroclearance in Chinese patients receiving lamivudine therapy for chronic hepatitis B virus infection, Journal of Clinical Microbiology. 2004, 42(10): 4882-4.

Yuen R.M.F., Yuan H., Sablon E., Wong D.K.H., Chan O.O., Wong B.C.Y. and Lai C.L., Long-term follow-up study of Chinese patients with YMDD mutations: significance of hepatitis B virus genotypes and characteristics of biochemical flares, Journal of Clinical Microbiology. 2004, 42(9): 3932-6.

Yuen R.M.F., Fung S.K., Tanaka Y., Kato T., Mizokami M., Yuen J.C.H., Wong D.K.H., Yuan H., Sum S.M., Chan O.O., Wong B.C.Y. and Lai C.L., Longitudinal study of hepatitis activity and viral replication before and after HBeAg seroconversion in chronic hepatitis B patients infected with genotypes B and C., Journal of Clinical Microbiology. 2004, 42(11): 5036-40.

Yuen R.M.F., Yuan H., Wong D.K.H., Yuen J.C.H., Wong R.W.M., Chan O.O., Wong B.C.Y., Lai K.C. and Lai C.L., Prognostic determinants for chronic hepatitis B in Asians: therapeutic implications., Gut. 2005, online.

Yuen R.M.F., Tanaka K., Mizokami M., Yuen J.C.H., Hui C.K., Wong D.K.H., Yuan H., Sum S.M., Chan O.O., Wong B.C.Y., Fan S.T. and Lai C.L., Role of hepatitis B virus genotypes Ba and C, core promoter and precore mutations on hepatocellular carcinoma: a case control study, Carcinogenesis. 2004, 25(9): 1593-1598.

Researcher : Yuen H

List of Research Outputs

Sum S.M., Wong D.K.H., Yuen R.M.F., Yuen H., Yu J., Lai C.L., Ho D. and Zhang L., Real-time PCR Assay Using Molecular Beacon for Quantitation of Hepatitis B Virus DNA, Journal of Clinical Microbiology. 2004, 42: 3438-3440.

Researcher : Yuen JCH

List of Research Outputs

Yuen M.F., Ng I.O.L., Fan S.T., Yuan H., Wong D.K.H., Yuen J.C.H., Sum S.M., Chan O.O. and Lai C.L., Significance of HBV DNA levels in liver histology of HBeAg and anti-HBe positive patients with chronic hepatitis B, American Journal of Gastroenterology. 2004, 99(10): 2032-2037.

Yuen R.M.F., Wong D.K.H., Sum S.M., Yuan H., Yuen J.C.H., Chan O.O., Wong B.C.Y. and Lai C.L., Effect of lamivudine therapy on the serum covalently closed circular DNA of chronic hepatitis B infection., 55th Annual Meeting of the American Association for the Study of Liver Diseases, Boston, USA 29 Oct-2 Nov 2004 (Published in Hepatology). 2004, 40(4): 671A.

Yuen R.M.F., Wong D.K.H., Sum S.M., Yuan H., Yuen J.C.H., Chan O.O., Wong B.C.Y. and Lai C.L., Effect of lamivudine therapy on the serum covalently closed-circular (ccc) DNA of chronic hepatitis B infection., American Journal of Gastroenterology. 2005, 100(5): 1099-103.

Yuen R.M.F., Wong D.K.H., Chan C.S., Zhang Z., Yuen J.C.H. and Lai C.L., Immune Response During Immunoclearance Phase of Chinese Patients with HBV Genotypes B and C, Journal of Hepatology. 2005, 42 (Suppl 2): 152.

Yuen R.M.F., Chow D.H.F., Tsui K., Wong B.C.Y., Yuen J.C.H., Wong D.K.H. and Lai C.L., Liver histology of Asian patients with chronic hepatitis B on prolonged lamivudine therapy, Alimentary Pharmacology and Therapeutics. 2005, 21(7): 841-9.

Yuen R.M.F., Fung S.K., Tanaka Y., Kato T., Mizokami M., Yuen J.C.H., Wong D.K.H., Yuan H., Sum S.M., Chan O.O., Wong B.C.Y. and Lai C.L., Longitudinal study of hepatitis activity and viral replication before and after HBeAg seroconversion in chronic hepatitis B patients infected with genotypes B and C., Journal of Clinical Microbiology. 2004, 42(11): 5036-40.

Yuen R.M.F., Kim J., Averett D., Wong D.K.H., Kim C.R., Kerr B., Ngai W.S., Yuen J.C.H. and Lai C.L., Phase I/II double-blind, randomized, placebo-controlled study of the novel anti-HBV agent LB80380/ANA380 in patients with chronic HBV infection., 55th Annual Meeting of the American Association for the Study of Liver Diseases, Boston, USA 29 Oct-2 Nov 2004 (Published in Hepatology). 2004, 40 (4 Suppl 1): 172A.

Yuen R.M.F., Yuan H., Wong D.K.H., Yuen J.C.H., Wong R.W.M., Chan O.O., Wong B.C.Y., Lai K.C. and Lai C.L., Prognostic determinants for chronic hepatitis B in Asians: therapeutic implications., Gut. 2005, online.

Yuen R.M.F., Tanaka K., Mizokami M., Yuen J.C.H., Hui C.K., Wong D.K.H., Yuan H., Sum S.M., Chan O.O., Wong B.C.Y., Fan S.T. and Lai C.L., Role of hepatitis B virus genotypes Ba and C, core promoter and precore mutations on hepatocellular carcinoma: a case control study, Carcinogenesis. 2004, 25(9): 1593-1598.

Researcher : Yuen MF

List of Research Outputs

Gu Q., Xia H.H.X., Wang W., Wang J., Wong R.W.M., Chan O.O., Yuen M.F., Lam S.K., Cheung K.L., Liu X.G. and Wong B.C.Y., Effect of Cyclo-Oxygenase Inhibitors on Helicobacter pylori Susceptibility to Metronidazole and Clarithromycin, Alimentary Pharmacology and Therapeutics. 2004, 20: 675-681.

Jiang X., Tu S., Cui J., Lin M.C., Xia H.H.X., Wong R.W.M., Chan O.O., Yuen M.F., Jiang S.H., Lam S.K., Kung H., Soh J.W., Weinstein I.B. and Wong B.C.Y., Antisense Targeting Protein Kinase C Alpha and Beta1 Inhibits Gastric Carcinogenesis, Cancer Research. 2004, 64: 5787-5794.

To Y.F., Ip E.W.K., Chong W.P., Yuen M.F., Poon R.T.P., Wong W.H.S., Lai C.L. and Lau Y.L., Mannose Binding Lectin in Chronic Hepatitis B Virus Infection, Ruby Jubilee Scientific Meeting, HK, 24-26 Sepember 2004. Abstract in Hong Kong Journal of Paediatrics (new series). 2004, 9 (suppl): 47.

Yuen M.F., Ng I.O.L., Fan S.T., Yuan H., Wong D.K.H., Yuen J.C.H., Sum S.M., Chan O.O. and Lai C.L., Significance of HBV DNA levels in liver histology of HBeAg and anti-HBe positive patients with chronic hepatitis B, American Journal of Gastroenterology. 2004, 99(10): 2032-2037.

Researcher : Yuen RMF

List of Research Outputs

Chan O.O., Chu K.M., Sun Y., Cheung K.L., Lam S.K., Yuen R.M.F., Hui W.M. and Wong B.C.Y., The association between Interleukin 1 beta polymorphism and hypermethylation at tumor suppressor genes in gastric cancer. Conference paper at the Annual Meeting of the American Gastroenterology Associatoin, Digestive Diseases Week (DDW) Chicago, Illinois, USA. May 14-19, Gastroenterology. 2005, 128(4 Suppl 2): A399.

Gu Q., Wang J., Xia H.H.X., Lin M.C., He H., Zou B., Tu S., Yang Y., Liu X.G., Lam S.K., Wong R.W.M., Chan O.O., Yuen R.M.F., Kung H. and Wong B.C.Y., Activation of the Caspase-8/Bid and Bax Pathways in Aspirin-Induced Apoptosis in Gastric Cancer, Carcinogenesis. 2005, 26(3): 541-546.

Hui C.K., Lai K.C., Wong R.W.M., Yuen R.M.F., Ng M.M.T., Chan C.K., Hu H.C., Cheung W.W., Lai C.L. and Wong B.C.Y., Outpatients Undergoing Therapeutic Endoscopic Retrograde Cholangiopancreatography: Six-hour Versus Overnight Observation , Journal of Gastroenterology and Hepatology. 2004, 19: 1163-1168.

Lai C.L., Lim S.G., Brown N.A., Zhou X.J., Lloyd D.M., Lee Y.M., Yuen R.M.F., Chao G.C. and Myers M.W., A Dose-finding Study of Once-daily Oral Telbivudine in HBeAg-positive Patients with Chronic Hepatitis B Virus Infection, Hepatology. 2004, 40: 719-726.

Lai C.L., Han K.H., Yoon S.K., Um S.H., Yuen R.M.F., Kim H.S., Kim H.R., Chung H.C., Kim C.R., Hsyu P., Averett D. and Kim J., Interim Report for a Phase II, Multi-centre, Dose-escalating Study of LB80380/ANA380 in Hepatitis B Patients with Lamivudine-resistant YMDD Mutant HBV, Journal of Hepatology. 2005, 42 (Suppl 2): 31.

Lai C.L. and Yuen R.M.F., Interpreting Abnormal Laboratory Findings: Liver Function , 9th Hong Kong Medical Forum. 2004.

Lai C.L., Brown N.A., Yuen R.M.F., Wai C.T., Lloyd D., Pietropaolo K., Zhou X.J., Chao G. and Lim S.G., Valtorcitabine provides potent suppression of hepatitis B virus in patients with chronic hepatitis B: Results of a phase I/II clinical trial. , 55th Annual Meeting of the American Association for the Study of Liver Diseases, Boston, USA 29 Oct-2 Nov 2004 (Published in Hepatology) . 2004, 40(4): 173A.

Lim S.G., Lai C.L., Myers M., Yuen R.M.F., Wai C.T., Lloyd D., Pietropalolo K., Zhou X.J., Chao G. and Brown N.A., Final Results of a Phase I/II Dose Escalation Trial of Valtorcitabine in Patients with Chronic Hepatitis B, Journal of Hepatology. 2005, 42 (Suppl 2): 16.

Sum S.M., Wong D.K.H., Yuen R.M.F., Yuen H., Yu J., Lai C.L., Ho D. and Zhang L., Real-time PCR Assay Using Molecular Beacon for Quantitation of Hepatitis B Virus DNA, Journal of Clinical Microbiology. 2004, 42: 3438-3440.

Tu S., Cui J., Liston P., Jiang X., Xu R., Lin M.C., Zhu Y.B., Zou B., Ng S.M., Jiang S.H., Xia H.H.X., Wong R.W.M., Chan O.O., Yuen R.M.F., Lam S.K., Kung H. and Wong B.C.Y., Gene Therapy for Colon Cancer by Adeno-Associated Viral Vector-Mediated Transfer of Survivin Cys84Ala Mutant, Gastroenterology. 2005, 128: 361-375.

Wong B.C.Y., Chan O.O., Wong K.W., Ching C.K., Wong R.W.M., Tam S., Lai K.C., Chan C.K., Yuen R.M.F. and Lam S.K., A pilot study of participation in faecal occult blood testing and screening colonoscopy after health education in Hong Kong, European Journal of Cancer Preview. 2005, 14(2): 181-184.

Wong D.K.H., Yuen R.M.F., Tse E.W.C., Yuan H., Sum S.M., Hui C.K. and Lai C.L., Detection of Intrahepatic Hepatitis B Virus DNA and Correlation with Hepatic Necroinflammation and Fibrosis, Journal of Clinical Microbiology. 2004, 42: 3920-3924.

Wong D.K.H., Yuen R.M.F., Yuan H., Sum S.M., Hui C.K., Hall J. and Lai C.L., Quantitation of Covalently Closed Circular Hepatitis B Virus DNA in Chronic Hepatitis B Patients, Hepatology. 2004, 40: 727-737.

Yuan H., Yuen R.M.F., Wong D.K.H., Sum S.M. and Lai C.L., Clinical Evaluation of the Digene Hybrid Capture II Test and the COBAS AMPLICOR Monitor Test for Determination of Hepatitis B Virus DNA Levels, Journal of Clinical Microbiology. 2004, 42: 3513-3517.

Yuan H., Yuen R.M.F., Wong D.K.H., Sum S.M., Doutreloigne J., Sablon E. and Lai C.L., Determinants for the Occurrence of Acute Exacerbation of Hepatitis B Virus Infection in Chinese Patients after HBeAg Seroclearance , Journal of Clinical Microbiology. 2005, 43: 1594-1599.

Yuen R.M.F., Lim W.L., Chan O.O., Wong D.K.H., Sum S.M. and Lai C.L., 18-year follow-up study of a prospective randomized trial of hepatitis B vaccinations without booster doses in children, Clinical Gastroenterology and Hepatology. 2004, 2(10): 941-5.

Yuen R.M.F. and Lai C.L., Adefovir dipivoxil in chronic hepatitis B infection, Expert Opinion on Pharmacotherapy. 2004, 5(11): 2361-7.

Yuen R.M.F., Distinguished Research Paper Award for Young Investigators, Hong Kong College of Physicians . 2004.

Yuen R.M.F., Wong D.K.H., Sum S.M., Yuan H., Yuen J.C.H., Chan O.O., Wong B.C.Y. and Lai C.L., Effect of lamivudine therapy on the serum covalently closed circular DNA of chronic hepatitis B infection., 55th Annual Meeting of the American Association for the Study of Liver Diseases, Boston, USA 29 Oct-2 Nov 2004 (Published in Hepatology). 2004, 40(4): 671A.

Yuen R.M.F., Wong D.K.H., Sum S.M., Yuan H., Yuen J.C.H., Chan O.O., Wong B.C.Y. and Lai C.L., Effect of lamivudine therapy on the serum covalently closed-circular (ccc) DNA of chronic hepatitis B infection., American Journal of Gastroenterology. 2005, 100(5): 1099-103.

Yuen R.M.F., Sablon E., Tanaka Y., Kato T., Mizokami M., Doutreloigne J., Yuan H., Sum S.M. and Lai C.L., Epidemiological study of hepatitis B virus genotypes, core promoter and precore mutations of chronic hepatitis B infection in Hong Kong. , Journal of hepatology : the journal of the European Association for the Study of the Liver. 2004, 41(1): 119-25.

Yuen R.M.F., HBeAg+ & HBeAg- chronic hepatitis B – how to treat? , Joint HKMA-HKASLD CME course in chronic hepatitis B management, Hong Kong. 2005.

Yuen R.M.F., HBsAg Seroclearance in Chronic Hepatitis B in The Chinese: Virological, Histologic and Clinical Aspects, Joint Scientific Meeting, Hong Kong College of Physicians, Hong Kong . 2004.

Yuen R.M.F., Wong D.K.H., Yuan H., Sum S.M. and Lai C.L., HBsAg seroclearance in Chinese patients receiving lamivudine therapy for chronic hepatitis B virus infection, Journal of Clinical Microbiology. 2004, 42(10): 4882-4.

Yuen R.M.F., Ip P., Ng W.K. and Lai C.L., Hepatotoxicity due to a formulation of Ganoderma lucidum (lingzhi)., Journal of hepatology : the journal of the European Association for the Study of the Liver. 2004, 41(4): 686-7.

Yuen R.M.F., Wong D.K.H., Chan C.S., Zhang Z., Yuen J.C.H. and Lai C.L., Immune Response During Immunoclearance Phase of Chinese Patients with HBV Genotypes B and C, Journal of Hepatology. 2005, 42 (Suppl 2): 152.

Yuen R.M.F., Hon C., Hui C.K., Siu C.W. and Lai C.L., Interferon treatment for metastatic hepatocellular carcinoma. Review Series, Hepatitis. 2004, 3: 12-3.

Yuen R.M.F., Interpreting abnormal laboratory findings, 9th Hong Kong Medical Forum (9th HKMF) Hong Kong Convention and Exhibition Centre . 2004.

Yuen R.M.F., Chow D.H.F., Tsui K., Wong B.C.Y., Yuen J.C.H., Wong D.K.H. and Lai C.L., Liver histology of Asian patients with chronic hepatitis B on prolonged lamivudine therapy, Alimentary Pharmacology and Therapeutics. 2005, 21(7): 841-9.

Yuen R.M.F., Yuan H., Sablon E., Wong D.K.H., Chan O.O., Wong B.C.Y. and Lai C.L., Long-term follow-up study of Chinese patients with YMDD mutations: significance of hepatitis B virus genotypes and characteristics of biochemical flares, Journal of Clinical Microbiology. 2004, 42(9): 3932-6.

Yuen R.M.F., Fung S.K., Tanaka Y., Kato T., Mizokami M., Yuen J.C.H., Wong D.K.H., Yuan H., Sum S.M., Chan O.O., Wong B.C.Y. and Lai C.L., Longitudinal study of hepatitis activity and viral replication before and after HBeAg seroconversion in chronic hepatitis B patients infected with genotypes B and C., Journal of Clinical Microbiology. 2004, 42(11): 5036-40.

Yuen R.M.F., Kim J., Averett D., Wong D.K.H., Kim C.R., Kerr B., Ngai W.S., Yuen J.C.H. and Lai C.L., Phase I/II double-blind, randomized, placebo-controlled study of the novel anti-HBV agent LB80380/ANA380 in patients with chronic HBV infection., 55th Annual Meeting of the American Association for the Study of Liver Diseases, Boston, USA 29 Oct-2 Nov 2004 (Published in Hepatology). 2004, 40 (4 Suppl 1): 172A.

Yuen R.M.F., Preventing disease progression in chronic hepatitis B, Annual Scientific Meeting of the Malaysian Society of Gastroenterology and Hepatology, The Andaman Langkawi, Pulau Langkawi, Malaysia. 2005.

Yuen R.M.F., Yuan H., Wong D.K.H., Yuen J.C.H., Wong R.W.M., Chan O.O., Wong B.C.Y., Lai K.C. and Lai C.L., Prognostic determinants for chronic hepatitis B in Asians: therapeutic implications., Gut. 2005, online.

Yuen R.M.F., Recent advances in chronic hepatitis B, The sixth joint scientific meeting, The Hong Kong Society of Gastroenterology, Hong Kong Society of Digestive Endoscopy, Hong Kong Society for Coloproctology, The Hong Kong Association for the Study of Liver Diseases, and The Hong Kong Society of Gastrointestinal Motility. Hong Kong. 2004.

Yuen R.M.F., Tanaka K., Mizokami M., Yuen J.C.H., Hui C.K., Wong D.K.H., Yuan H., Sum S.M., Chan O.O., Wong B.C.Y., Fan S.T. and Lai C.L., Role of hepatitis B virus genotypes Ba and C, core promoter and precore mutations on hepatocellular carcinoma: a case control study, Carcinogenesis. 2004, 25(9): 1593-1598.

Yuen R.M.F., Screening for hepatocellular carcinoma – State-of-the-Art Lecture, CSLD 6th annual scientific meeting. Hong Kong. 2005.

Yuen R.M.F. and Lai C.L., Serological markers of liver cancer., Best Practice & Research, Clinical Gastroenterology. 2005, 19(1): 91-9.

Yuen R.M.F. and Lai C.L., Treatment for hepatitis B: a public health perspective., Journal of Clinical Gastroenterology. 2004, 38(10 Suppl): 134-5.

Yuen R.M.F. and Lai C.L., Treatment of chronic hepatitis B, Medical Progress. 2005, 32(7): 349-56.

Yuen R.M.F., Update in the management of chronic viral hepatitis – chronic hepatitis B, 2004 autumn meeting of the Korean association for the study of the liver. Seoul, South Korea. 2004.

Zhang L., Chen Z., Cao Y., Yu J., Li G., Yu W., Yin N., Mei S., Li L., Balfe P., He T., Ba L., Zhang F., Lin H.H., Yuen R.M.F., Lai C.L. and Ho D.D., Molecular Characterization of Human Immunodeficiency Virus Type 1 and Hepatitis C Virus in Paid Blood Donors and Injection Drug Users in China , Journal of Virology. 2004, 78: 13591-13599.

Researcher : Yueng YH

List of Research Outputs

Hui C.K., Sun J., Au W.Y., Lie A.K.W., Yueng Y.H., Zhang H., Lee N.P., Hou J., Liang R.H.S. and Lau G., Occult hepatitis B virus infection in hematopoietic stem cell donors in a hepatitis B virus endemic area, Journal of Hepatology. 2005, 42(6): 813-9.

Researcher : Yung LY

List of Research Outputs

Siu C.W., Tse H.F., Lee K.L.F., Lam Y.M., Yung L.Y. and Lau C.P., A rapid ultrasonic cardiac output monitor method for optimization of ventriculo-ventricular interval (VVI) in cardiac resynchronization therapy., Heart Rhythm. 2005, 2: S84.

Researcher : Yung SSY

Project Title:	The role of hyaluronan and cytoskeletal proteins in mediating human peritoneal mesothelial cell transdifferentiation during peritoneal dialysis
Investigator(s):	Yung SSY, Chan DTM
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2004

Abstract:

To isolate human peritoneal mesothelial cells (HPMC) in spent PD fluid obtained from patients on long-term PD, and to determine the ratio of non-transdifferentiated and transdifferentiated mesothelial cells. The cell morphology and cytoskeleton will be compared with normal HPMC isolated from omental specimens from non PD patients during abdominal surgery; to assess hyaluronan synthesis (at transcription and translation) during mesothelial cell transformation; to determine concomitant changes in the cytoskeleton (vimentin, cytokeratin, and [alpha]-smooth muscle actin), and epithelial markers (E-cadherin , occludin ZO-1).

Project Title:	Transdifferentiation of human peritoneal mesothelial cells during peritoneal dialysis - the role of hyaluronan
Investigator(s):	Yung SSY
Department:	Medicine
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2004

Abstract:

Refer to hard copy

Project Title:	The role of thrombospondin-1 in the activation of TGF-beta1, and synthesis of matrix proteins in human proximal tubular epithelial cells under elevated glucose concentrations - implications in diabetic nephropathy
Investigator(s):	Yung SSY, Chan DTM
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2005

Abstract:

Background Nephropathy in patients with type I and II diabetes mellitus is a rapidly increasing problem worldwide, and is the most important cause of end-stage renal failure, accounting for 40% of new patients who require renal replacement therapy (1). The incidence of diabetic nephropathy (DN) will continue to increase, attributed in part by the improved survival of type II patients as the cardiovascular mortality in this group declines (2). DN is initiated by hyperglycaemia and characterized by cell proliferation, and thickening of tubular and glomerular basement membranes due to an excessive accumulation of extracellular matrix proteins that ultimately results in progressive scarring and fibrosis of the kidney (3). Clinically, DN manifests itself by the onset of continuous microalbuminuria followed by the appearance of persistent proteinuria. This is subsequently followed by a progressive decline in glomerular filtration rate leading to end-stage renal failure (4). Although DN was traditionally considered to be primarily a glomerular disease, recent studies have demonstrated that the rate of kidney function deterioration correlates best with the degree of tubulo-interstitial fibrosis (5). This therefore suggests that although glomerular changes are predominantly observed in diabetic patients, the long-term outcome is determined by events in the tubulo-interstitium. Proximal tubular epithelial cells (PTEC) constitutes the predominant cell type within the tubulo-interstitium. Although previously considered to be mainly involved in the transport of fluid and electrolytes, there is increasing evidence that they play a critical role in the immunopathogenesis of various renal parenchymal diseases, and act as a regulator/effector of immune-mediated inflammation and fibrosis (6). Thus, PTEC are not only affected secondary to glomerular injury, but are primary targets for pathological influences in DN. Animal and in vitro studies have shown that under elevated glucose concentrations, PTEC can directly contribute to the pathogenesis of renal fibrosis by induced synthesis of extracellular matrix proteins such as collagen type I and fibronectin through the enhanced secretion of the pro-fibrotic growth factor transforming growth factor-beta1 (TGF-beta1) (7-9). TGF-beta1 is normally synthesized and secreted in its latent form, and thus must be activated before it can bind to its receptors. Thus, changes in the expression of latent TGF-beta1 will have no biologic effect on the kidney parenchyma unless mechanisms are present to convert it to the active form. In the latent form, TGF-beta1 is non-covalently associated with a disulfide-linked dimer of the N-terminal part of the TGF-beta1 molecule, referred to as the latency-associated peptide (LAP). Physicochemical activation can occur by extreme pH or high temperature (10), limited proteolysis or deglycosylation of LAP (11), or binding to various membrane or extracellular matrix components. Activation in vivo is more complex and not well understood. Studies have documented that the extracellular matrix molecule thrombospondin-1 (TSP-1) is associated with TGF-beta1 as an active complex in stimulated platelets (12). Furthermore, TSP-1 has been shown to precede the development of tubulo-interstitial fibrosis in glomerular disease, and recent studies have shown TSP-1 to be the key activator of this pro-fibrotic peptide in human mesangial cells after exposure to elevated glucose concentrations (13-15). How TGF-beta1 is activated in PTEC in DN has not been investigated. We hypothesize that TSP-1 may activate TGF-beta1 in PTEC and contribute to tubulo-interstitial fibrosis. The objectives of this project are thus: 1. To assess PTEC proliferation and viability under physiological and elevated glucose concentrations pertaining to DN. 2. To assess gene expression and protein translation of TGF-beta1, matrix proteins (fibronectin, collagen type I, III and IV) and TSP-1 under different glucose concentrations, and correlate TSP-1 synthesis with TGF-beta1 activation and matrix protein synthesis.. 3. To determine the bioactivity of TGF-beta1 secreted under control and elevated glucose concentrations. 4. To examine the effect of exogenous TSP-1 on TGF-beta1 bioactivity and matrix protein synthesis in PTEC, and to determine whether TSP-1 can directly modulate matrix synthesis or act only through induction of TGF-beta1 activation. References 1. Gilbert RE, Cooper ME. Kidney Int. 1999; 56: 1627-1637. 2. Ritz E, Stefanski A. Am J Kidney Dis. 1996; 27: 167-194. 3. Amos AF, McCarty DJ, Zimmet P. Diabet Med. 1997; 14: S1-S85. 4. Phillips AO, Steadman R. Histol Histopathol. 2002; 17: 247-252. 5. Bohle A, Wehrmann M, Bogenschutz O, Batz C, Muller CA, Muller GA. Pathol Res Pract. 1991; 187: 251-259. 6. Tang WW, Feng L, Xia Y, Wilson CB. Kidney Int. 45: 1994; 1077-1084. 7. Phillips AO, Steadman R, Topley N, Williams JD. Am J Pathol. 1995; 147: 362-374. 8. Phillips AO, Steadman R, Morrisey K, Martin J, Eynstone L, Williams JD. Kidney Int. 1997; 52: 973-984. 9. Morrisey K, Steadman R, Williams JD, Phillips AO. Kidney Int. 1999; 55: 2548-2572. 10. Brown PD, Wakefield LM, Levinson AD, Sporn MB. Growth Factors 1990; 3: 35-43. 11. Lyons R, Gentry LE, Purchio AF, Moses HL. J Cell Biol. 1990; 110: 1361-1367. 12. Murphy-Ullrich JE, Schultz-Cherry S, Hook M. Mol Biol Cell. 1992; 3: 181-188. 13. Poczatek MH, Hugo C, Darley-Usmar V, Murphy-Ullrich JE. Am J Pathol. 2000; 157: 1353-1363. 14. Yevdokimova N, Abdel Wahab N, Mason RM. J Am Soc Nephrol. 2001; 12: 703-712. 15. Hugo C, Shankland SJ, Pichler RH, Couser WG, Johnson RJ. Kidney Int. 1998; 53: 302-311.

List of Research Outputs

Chan D.T.M., Tsang R.C.W., Tsang W.S. and Yung S.S.Y., Induction of Proximal Tubular Epithelial Cell Interleukin-6 Synthesis by Anti-DNA Antibodies Varies with the Activity of Lupus Nephritis, Journal of the American Society of Nephrology. 2004, 15: 684A.

Yung S.S.Y., Tsang R.C.W., Leung J.K.H. and Chan D.T.M., Anti-DNA antibodies from patients with lupus nephritis induce IL-6 expression in renal tubular epithelial cells, Nephrology. 2005, 10: A277.

Yung S.S.Y., Liu Z.H., Li L.S. and Chan D.T.M., Emodin abrogates mediators of inflammation and fibrosis and morphological changes in human peritoneal mesothelial cells induced by peritoneal dialysis fluid, Nephrology. 2005, 2005: A64.

Yung S.S.Y., Tsang R.C.W., Leung J.K.H. and Chan D.T.M., Induction of IL-6 by anti-DNA antibodies in proximal tubular epithelial cells varies with the activity of lupus nephritis, Lupus. 2005, 14: 237.

Yung S.S.Y., Tsang R.C.W., Leung J.K.H. and Chan D.T.M., Induction of IL-6 synthesis in proximal tubular epithelial cells by anti-DNA antibodies varies with lupus nephritis activity, 10th Medical Research Conference. 19-20 February 2005. Nephrology 45.

Yung S.S.Y., Pathogenetic Role of Anti-DNA Antibodies in Lupus Nephritis, Forefronts in Glomerular Disease Nanjing Forum 2004. 2004.

Zhang Q., Yung S.S.Y., Leung J.K.H. and Chan D.T.M., High Glucose Concentration Reduces Human Mesangial Cell alpha-actinin-1 and F-actin Expression through the induction of TGF-beta1 and PKC-alpha, Journal of the American Society of Nephrology. 2004, 15: 726A.

Zhang Q., Yung S.S.Y., Leung J.K.H. and Chan D.T.M., The effect of elevated glucose concentration on the expression of alpha-actinin-1 and F-actin in human mesangial cells, 10th Medical Research Conference. 19-20 February 2005. Nephrology 47.

Researcher : Zhang H

List of Research Outputs

Hui C.K., Lie A., Au W.Y., Leung A.Y.H., Ma S.Y., Cheung W.W., Zhang H., Chim C.S., Kwong Y.L., Liang R.H.S. and Lau G., A long-term follow-up study on hepatitis B surface antigen-positive patients undergoing allogeneic hematopoietic stem cell transplantation, Blood. 2005, 106: 464-9.

Hui C.K., Lie A.K.W., Au W.Y., Ma S.Y., Leung A.Y.H., Zhang H., Sun J.Z., Cheung W.W.W., Chim J.C.S., Kwong Y.L., Liang R.H.S. and Lau G., Effectiveness of prophylactic Anti-HBV therapy in allogeneic hematopoietic stem cell transplantation with HBsAg positive donors, American Journal of Transplantation. 2005, 5(6): 1437-45.

Hui C.K., Zhang H. and Lau G., Management of chronic hepatitis B in treatment-experienced patients, Gastroenterol Clin North Am. 2004, 33: 601-16.

Hui C.K., Sun J., Au W.Y., Lie A.K.W., Yueng Y.H., Zhang H., Lee N.P., Hou J., Liang R.H.S. and Lau G., Occult hepatitis B virus infection in hematopoietic stem cell donors in a hepatitis B virus endemic area, Journal of Hepatology. 2005, 42(6): 813-9.

Hui C.K., Yu J., Au W.Y., Zhang H., Bartholomeusz A., Locarnini S., Kwong Y.L., Liang R.H.S. and Lau G., Sexual transmission of hepatitis B infection despite the presence of hepatitis B virus immunity in recipients of allogeneic bone marrow transplantation, J Clin Virol. 2005, 32: 173-8.

Researcher : Zhang J

List of Research Outputs

Chan K.W., Xu A., Hoo R.L.C., Tan K.C.B., Zhang J., Lam C.W. and Lam K.S.L., Selective Reduction of the High Molecular Weight Form of Adiponectin by Testosterone: A Potential Mechanism That Underlies the Sexual Dimorphism of Adiponectin Oligomeric Distribution, The Endocrine Society’s 87th Annual Meeting, June 4-7, 2005, San Diego, USA. 2005.

Sae-Pang J.J., Zhang J. and Sham M.H., Analysis of multiple cardiac abnormalities of a knockout mouse mutant Hoxb3-lacZ, Joint Research Retreat for Young Scientists, HKU - Cambridge - HKUST, 10-12 March 2005 . 2005.

Sae-Pang J.J., Zhang J. and Sham M.H., Analysis of multiple cardiac abnormalities of a knockout mouse mutant Hoxb3Hoxb3^lacZ, 9th Rearch Postgraduate Symposium, HKU 4 December 2004 . 2004.

Xu A., Chan K.W., Wang Y., Zhang J., Hoo R.L.C., Xu J., Chow W.S. and Lam K.S.L., Angiopoietin-like Protein 4 Decreases Blood Glucose and Improves Glucose Tolerance but Induces Hyperlipidemia and Hepatic Steatosis in Mice, Proceedings of the National Academy of Sciences of the United States of America. 2005, 102: 6086-6091.

Xu A., Lam C.W., Chan K.W., Zhang J., Hoo R.L.C., Xu J., Chen B. and Lam K.S.L., Angiopoietin-like protein 4 is a novel metabolic hormone with therapeutic potentials for hyperglycemia and insulin resistance, 10th Medical Research Conference, The University of Hong Kong. 19-20 Feb 2005. Endocrinology 22.

Xu A., Chan K.W., Hoo R.L.C., Wang Y., Zhang J., Chen B., Cynthia T., Cooper G.J.S. and Lam K.S.L., Testosterone Selectively Reduces the High Molecular Weight Form of Adiponectin by Inhibiting Its Secretion from Adipocytes, The Journal of Biological Chemistry. 2005, 280: 18073-18080.

Researcher : Zhang JCL

Project Title:	Functional analysis of SM22[beta] by tissue-specific targeted deletion in mice
Investigator(s):	Zhang JCL, Cheah KSE, Lau CP, Feil R., Parmacek M.S.
Department:	Medicine
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	09/2003
Completion Date:	09/2005

Abstract:

To determine the general role of SM22[beta] in a cell; to understand the specific role of SM22[beta] in cardiovascular development.

Project Title:	Cardiovascular analysis of a novel murine model of cardiomyopathy and sudden death
Investigator(s):	Zhang JCL
Department:	Medicine
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2004
Completion Date:	09/2005

Abstract:

Refer to hard copy

List of Research Outputs

Chan K.W., Fong S.W., Mak H.S., Zhang J.C.L. and Chan S.Y., The function of a new member of nucleosome assembly proteins NAP79: A transgenic study, 9th Research Postgraduate Symposium, HKU, 4 December 2004. 98.

Cheah K.S.E., Wong S.Y.Y., Zhang J.C.L., Leung W.L., Kung H. and Tam P.P.L., Genetic analysis of the role of procollagen IIA as an extracellular regulator of BMP signaling, Frontiers in Biomedical Research, HKU 2004, 3 December 2004 Hong Kong. 2004.

Liang Y., Zhang J.C.L., Higgins D.A. and Chan S.Y., Functional characteristics of SUN-2, 9th Research Postgraduate Symposium, HKU, 4 December 2004. 104.

Xu A., Lam M.C., Chan K.W., Wang Y., Zhang J.C.L., Xu J., Chen B., Chow W.S., Tso A.W. and Lam K.S.L., Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice, Proc Natl Academic Science USA. 2005, 102(17): 6086-91.

Xu A., Chan K.W., Hoo R.L.C., Wang Y., Tan K.C.B., Zhang J.C.L., Chen B., Lam M.C., Tse C., Cooper G.J. and Lam K.S.L., Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes, J Biol Chem. 2005, 280(18): 18073-80.

Researcher : Zhang Q

List of Research Outputs

Zhang Q., Yung S.S.Y., Leung J.K.H. and Chan D.T.M., High Glucose Concentration Reduces Human Mesangial Cell alpha-actinin-1 and F-actin Expression through the induction of TGF-beta1 and PKC-alpha, Journal of the American Society of Nephrology. 2004, 15: 726A.

Zhang Q., Yung S.S.Y., Leung J.K.H. and Chan D.T.M., The effect of elevated glucose concentration on the expression of alpha-actinin-1 and F-actin in human mesangial cells, 10th Medical Research Conference. 19-20 February 2005. Nephrology 47.

Researcher : Zhang Q

List of Research Outputs

Researcher : Zhang S

List of Research Outputs

Xia H.H.X., Zhang S., Lam S.K., Lin M.C., Kung H. and Wong B.C.Y., Expression of Macrophage Migration Inhibitory Factor in Esophageal Squamous Cell Carcinoma and Effects of Bile Acids and NSAIDs, Carcinogenesis. 2005, 26(1): 11-15.

Researcher : Zheng G

List of Research Outputs

Huang J., Zheng G., Hunt R.H., Wong R.W.M., Lam S.K., Karlberg J.P.E. and Wong B.C.Y., Do patients with non-ulcer dyspepsia respond differently to Helicobacter pylorieradication treatments from those with peptic ulcer disease? A systemic review, World Journal of Gastroenterology. 2005, 11 (18): 2726-2732.

Huang J., Zheng G., Chan G.C.F., Karlberg J.P.E., Lam S.K. and Wong B.C.Y., Efficacy of Current Antiemetic Treatments for Preventing Delayed Chemotherapy-Induced Nausea and Vomiting: A Meta-Analysis of Randomized Controlled Trials, Clinical Research and Regulatory Affairs. 2004, 21 (3&4): 191-212.

Wang W.H., Huang J., Zheng G., Wong R.W.M., Lam S.K., Karlberg J.P.E., Xia H.H.X., Fass R. and Wong B.C.Y., Is Proton Pump Inhibitor Testing an Effective Approach to Diagnose Gastroesophageal Reflux Disease in Patients With Noncardiac Chest Pain?, Archives of Internal Medicine. 2005, 165: 1222-1228.

Researcher : Zhu S

List of Research Outputs

Zhu S., Xia H.H.X., Lam S.K., Yu L., Yang Y., Sun Y., Wang J., Chan O.O. and Wong B.C.Y., Alterations of gastric homeoprotein expression in H. Pylori infection and/or intestinal metaplasia, Gastroenterology. 2005, 128(4 Suppl 2): A598.

Researcher : Zhuang Z

List of Research Outputs

Wang J., Zou B., Gu Q., Jiang B., Zhuang Z., Xia H.H.X., Lin M.C., Lam S.K., Kung H. and Wong B.C.Y., Down-regulation of XAF1 expression by its interacting protein FHL2 via p53-mediated transcription regulation, Gastroenterology. 2005, 128(4 Suppl 2): A105.

Wang J., Gu Q., He H., Jiang B., Zhuang Z., Xia H.H.X., Lin M.C., Lam S.K., Kung H. and Wong B.C.Y., Down-regulation of XIAP associated factor 1 (XAF1) through Hsf-1 binding in the promoter region, Gastroenterology. 2005, 128(4 Suppl 2): A105.

Zhuang Z., Tsao G.S.W., Xia H.H.X., He H., Chan O.O., Lam S.K. and Wong B.C.Y., COX-2 inhibition induces apoptosis in human esophageal epithelial cells: implication for chemoprevention, Gastroenterology. 2005, 128(4 Suppl 2): A299.

Researcher : Zou B

List of Research Outputs

Gu Q., Wang J., Xia H.H.X., Lin M.C., He H., Zou B., Tu S., Yang Y., Liu X.G., Lam S.K., Wong R.W.M., Chan O.O., Yuen R.M.F., Kung H. and Wong B.C.Y., Activation of the Caspase-8/Bid and Bax Pathways in Aspirin-Induced Apoptosis in Gastric Cancer, Carcinogenesis. 2005, 26(3): 541-546.

Tu S., Cui J., Liston P., Jiang X., Xu R., Lin M.C., Zhu Y.B., Zou B., Ng S.M., Jiang S.H., Xia H.H.X., Wong R.W.M., Chan O.O., Yuen R.M.F., Lam S.K., Kung H. and Wong B.C.Y., Gene Therapy for Colon Cancer by Adeno-Associated Viral Vector-Mediated Transfer of Survivin Cys84Ala Mutant, Gastroenterology. 2005, 128: 361-375.

Wang J., Zou B., Gu Q., Jiang B., Zhuang Z., Xia H.H.X., Lin M.C., Lam S.K., Kung H. and Wong B.C.Y., Down-regulation of XAF1 expression by its interacting protein FHL2 via p53-mediated transcription regulation, Gastroenterology. 2005, 128(4 Suppl 2): A105.

Researcher : Zou L

List of Research Outputs

Li G., Zou L., Jack C...R... and Yang E.S., Coenzyme Q10 Inhibited The Opening of the Mitochondrial Permeability Transition Pore to Protect SHSY5Y Neuronal Cells, The Alzheimer's Association International Conference on Prevention of Dementia. 2005, 143.

Li G., Zou L., Cao C., Jack C.R. and Yang E.S., Coenzyme Q10 Protects SHSY5Y Neuronal Cells by the Inhibition of the Opening of the Mitochondrial Permeability Transition Pore, Fourth World Conference of the International CoenzymeQ10 Association. 2005, 134-136.

Li G., Zou L., Cao C. and Yang E.S., Coenzyme Q10 Protects SHSY5Y Neuronal Cells form Toxicity of Beta Amyloid-42 via Inhibition of Mitochondrial Permeability Transition Pore Opening, Drug Discovery in Neurodegenerative Diseases. 2004, 34.

Li G., Zou L., Jack C...R... and Yang E.S., MRI Study the Neuroprotection of Melatonin in the COX-1 Gene Wild-Type Mice, 12th ISMRM. 2005, 999.

Li G., Zou L., Jack C...R... and Yang E.S., The effects of Coenzyme Q10 in Transgenic Mouse Models of Alzheimer's Disease and Cerebral Ischemia: Volume MRI Study, 12th ISMRM. 2005, 998.

Li G., Zou L., Jack C...R... and Yang E.S., Volume MRI Study: The Effects of Coenzyme Q10 in APP/PS1 Mouse Models of Alzheimer's Disease and Cerebral Ischemia, The Alzheimer's Association International Conference on Prevention of Dementia. 2005, 36.

Li G., Zou L., Jack C.R. and Yang E.S., Volume MRI Study: The Effects of Coenzyme Q10 in Transgenic Mouse Models of Alzheimer's Disease and Cerebral Ischemia, Fourth World Conference of the International CoenzymeQ10 Association. 2005, 38-40.

Zou L., Tang F. and Cheung R.T.F., Cerebral ischemia induces neuronal damage in APP/PS1 double transgenic mice via activation of JNK/P38 pathway, Society for Neuroscience 2004. 443.6.

Researcher : Zou L

List of Research Outputs

Li G., Zou L., Jack C...R... and Yang E.S., MRI Study the Neuroprotection of Melatonin in the COX-1 Gene Wild-Type Mice, 12th ISMRM. 2005, 999.

Li G., Zou L., Jack C...R... and Yang E.S., The effects of Coenzyme Q10 in Transgenic Mouse Models of Alzheimer's Disease and Cerebral Ischemia: Volume MRI Study, 12th ISMRM. 2005, 998.

Zou L., Tang F. and Cheung R.T.F., Cerebral ischemia induces neuronal damage in APP/PS1 double transgenic mice via activation of JNK/P38 pathway, Society for Neuroscience 2004. 443.6.

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