HKU-PASTEUR RESEARCH CENTRE LIMITED
| Researcher : Altmeyer RM |
| List of Research Outputs |
| Altmeyer R.M., Influenza pseudotype particles as tools for large scahle seroprevalence studies, 2006. |
| Altmeyer R.M., Respiratory Disease in the Tropics, 2005. |
| Garcia J., Wang P. and Altmeyer R.M., Dengue pseudotype viruses as tools to identify virus entry inhibitors, PDVI 2nd Asian Regional Dengue Research Network Meeting.. 2005. |
| Kien F.S., Kam Y.W., Roberts A., Cheung C.Y., Lamirande E. .W., Vogel L., Chu S.L., Chan C.M., Tse K.S., Subbarao K., Peiris J.S.M., Nal-Rogier B.T.M. and Altmeyer R.M., Immunization with trimeric S glycoprotein protects from SARS-CoV challenge despite the presence of in vitro facilitating antibodies, Joint Meeting of the 3 Divisions of the International Union of Microbiological Societies 2005 - XIII International Congress of Virology . 2005. |
| Researcher : Chan CM |
| List of Research Outputs |
| Kien F.S., Kam Y.W., Roberts A., Cheung C.Y., Lamirande E. .W., Vogel L., Chu S.L., Chan C.M., Tse K.S., Subbarao K., Peiris J.S.M., Nal-Rogier B.T.M. and Altmeyer R.M., Immunization with trimeric S glycoprotein protects from SARS-CoV challenge despite the presence of in vitro facilitating antibodies, Joint Meeting of the 3 Divisions of the International Union of Microbiological Societies 2005 - XIII International Congress of Virology . 2005. |
| Researcher : Chu SL |
| List of Research Outputs |
| Kien F.S., Kam Y.W., Roberts A., Cheung C.Y., Lamirande E. .W., Vogel L., Chu S.L., Chan C.M., Tse K.S., Subbarao K., Peiris J.S.M., Nal-Rogier B.T.M. and Altmeyer R.M., Immunization with trimeric S glycoprotein protects from SARS-CoV challenge despite the presence of in vitro facilitating antibodies, Joint Meeting of the 3 Divisions of the International Union of Microbiological Societies 2005 - XIII International Congress of Virology . 2005. |
| Researcher : Garcia J |
| List of Research Outputs |
| Garcia J., Wang P. and Altmeyer R.M., Dengue pseudotype viruses as tools to identify virus entry inhibitors, PDVI 2nd Asian Regional Dengue Research Network Meeting.. 2005. |
| Researcher : Kien FS |
| List of Research Outputs |
| Kien F.S., Kam Y.W., Roberts A., Cheung C.Y., Lamirande E. .W., Vogel L., Chu S.L., Chan C.M., Tse K.S., Subbarao K., Peiris J.S.M., Nal-Rogier B.T.M. and Altmeyer R.M., Immunization with trimeric S glycoprotein protects from SARS-CoV challenge despite the presence of in vitro facilitating antibodies, Joint Meeting of the 3 Divisions of the International Union of Microbiological Societies 2005 - XIII International Congress of Virology . 2005. |
| Researcher : Nal-Rogier BTM |
| List of Research Outputs |
| Kien F.S., Kam Y.W., Roberts A., Cheung C.Y., Lamirande E. .W., Vogel L., Chu S.L., Chan C.M., Tse K.S., Subbarao K., Peiris J.S.M., Nal-Rogier B.T.M. and Altmeyer R.M., Immunization with trimeric S glycoprotein protects from SARS-CoV challenge despite the presence of in vitro facilitating antibodies, Joint Meeting of the 3 Divisions of the International Union of Microbiological Societies 2005 - XIII International Congress of Virology . 2005. |
| Researcher : Peiris JSM |
| Project Title: | The application of DNA arrays to characterise the avian influenza gene pool in southern China |
| Investigator(s): | Peiris JSM, Guan Y, Shortridge KF, Yang MMS, Li K.S. |
| Department: | Microbiology |
| Source(s) of Funding: | Competitive Earmarked Research Grants (CERG) |
| Start Date: | 12/2002 |
| Abstract: |
| This project is a multi-institutional collaborative study for developing a high throughput DNA array to allow genotyping of influenza virus isolates of avian origin from Hong Kong and applying it to characterize the influenza virus gene pool in sourthern China. Through its application, it is expected to:- 1) identify the precursor virus that donated its internal genes to generate the mutiple reassortment of H5N1 isolated in Hong Kong markets in 2001; 2) define the frequency of reassortment between viruses of different virus lineages that co-circulate in poultry in Hong Kong and correlate this to host-specificity; and 3) investigate whether avian internal gene segments are transiently introduced into the human influenza gene pool. |
| Project Title: | Influenza pandemic preparedness in Asia (Research collaboration with national Institute of Allergy and Infectious Diseases (NIAID), St. Jude Children's Research Hospital, Inc. (SJCRH) and The University of Hong Kong) |
| Investigator(s): | Peiris JSM, Guan Y |
| Department: | Microbiology |
| Source(s) of Funding: | National Institutes of Health, US Department of Health and Human Services - General Award |
| Start Date: | 04/2003 |
| Abstract: |
| To study influenza pandemic preparedness in Asia. |
| Project Title: | Virus-cell interaction and the pathogenesis of SARS |
| Investigator(s): | Peiris JSM |
| Department: | Microbiology |
| Source(s) of Funding: | VCO SARS Research Fund |
| Start Date: | 07/2003 |
| Abstract: |
| To explore what is the biological basis for the selective attraction of macrophages to the lung; to study what immunopathological consequences follow. |
| Project Title: | Viral determinants underlying the increased secretion of pro-inflammatory cytokines in H5N1 infected human macrophages: a mechanism for the unusual severity of human H5N1 disease? |
| Investigator(s): | Peiris JSM, Guan Y, Lau ASY, Poon LLM |
| Department: | Microbiology |
| Source(s) of Funding: | Competitive Earmarked Research Grants (CERG) |
| Start Date: | 09/2003 |
| Abstract: |
| To identify the viral genetic determinants responsible for the differential cytokine hyper-induction associated with H5N1/97 viruses. We have already established the role of the viral NS gene, however, a role for other viral genes has not been excluded. we hypothesize (and have preliminary evidence) that one or more other viral genes are also involved in the hyper-induction of cytokines; to determine whether the avian viral genes/gene products of H5N1/97 directly up-regulate cytokine induction or lack "immune evasion" mechanisms evolved by human influenza viruses? to determine whether the differential up-regulation of cytokines associated with H5N1/97 is also observed in human lung epithelial cells (primary bronchial epithelial cells and human lung epithelial cell lines e.g. A549 cells. |
| Project Title: | Viral determinants underlying the increased secretion of pro-inflammatory cytokines in H5N1 infected human macrophages: a mechanism for the unusual severity of human H5N1 disease? |
| Investigator(s): | Peiris JSM, Guan Y, Lau ASY, Poon LLM |
| Department: | Microbiology |
| Source(s) of Funding: | Merit Award for RGC CERG Funded Projects |
| Start Date: | 09/2003 |
| Abstract: |
| N/A |
| Project Title: | The role of influenza virus gene constellation and viral morphology on cytokine induction, pathogenesis and viral virulence |
| Investigator(s): | Peiris JSM, Nicholls JM, Guan Y, Poon LLM |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 02/2005 |
| Abstract: |
| To correlate the cytokine induction phenotype with viral genotype and morphology. |
| Project Title: | Virology and pathogenesis of avian influenza and SARS |
| Investigator(s): | Peiris JSM |
| Department: | Microbiology |
| Source(s) of Funding: | Senior Medical Research Fellowships |
| Start Date: | 03/2005 |
| Completion Date: | 08/2005 |
| Abstract: |
| The main objectives of this project are: 1) To study the pathogenesis and clinical disease burden of influenza. 2) To consolidate this by achieving international recognition as a WHO Influenza Collaborating Center for Animal influenza viruses. |
| Project Title: | The macrophage in the pathogenesis of Severe Acute Respiratory Syndrome Coronavirus infection |
| Investigator(s): | Peiris JSM |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 12/2005 |
| Abstract: |
| The global gene expression profiling of SARS-CoV infected macrophages will provide the basis for a more detailed analysis of the signaling pathways involved in subsequent studies, and may provide rational and novel therapeutic options to be devised for treating SARS. |
| Project Title: | Mass Tag PCR: A novel, multiplex and potentially sensitive approach for the rapid detection of respiratory pathogens |
| Investigator(s): | Peiris JSM, Chiu SSS, Cheung CY |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 06/2006 |
| Abstract: |
| To divise, optimize and evaluate the Mass Tag PCR system for the rapid disgnosis for simultaneous screening of a wide spectrum of causative agents for human respiratory tract infections, including the avian influenza H5N1 and H7N7, SARS-coronavirus (SARS-CoV). Thiw will significantly facilitate better prevention, treatment and control of infectious diseases. |
| Project Title: | Pathogenesis, cell signaling and virus evolution of avian influenza A (H5N1) |
| Investigator(s): | Peiris JSM, Guan Y, Ip NT, Yang MMS, Lau ASY, Nicholls JM, Chen H, Poon LLM, Lau YL, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Central Allocation Vote - Group Research Project |
| Start Date: | 06/2006 |
| Abstract: |
| To study the continued evolution of H5N1 influenza viruses in Vietnam and Indonesia, in the context of the ongoing studies in Hong Kong and mainland China; to define differences in cell-signaling pathways activated by avian influenza A H5N1 compared to convetional human influenza (H1N1 or H3N2) in primary human macrophages and epithelial cells; to compare the biological characteristics of H5N1 viruses from Indonesia and Vietnam to define a basis for possible differential pathogenicity for humans; investigate the biological significance of specific viral genetic mutations/changes in recent h5N1 viruses in primary human cell culture models |
| List of Research Outputs |
| Researcher : Tse KS |
| List of Research Outputs |
| Kien F.S., Kam Y.W., Roberts A., Cheung C.Y., Lamirande E. .W., Vogel L., Chu S.L., Chan C.M., Tse K.S., Subbarao K., Peiris J.S.M., Nal-Rogier B.T.M. and Altmeyer R.M., Immunization with trimeric S glycoprotein protects from SARS-CoV challenge despite the presence of in vitro facilitating antibodies, Joint Meeting of the 3 Divisions of the International Union of Microbiological Societies 2005 - XIII International Congress of Virology . 2005. |
| Researcher : Wang P |
| List of Research Outputs |
| Garcia J., Wang P. and Altmeyer R.M., Dengue pseudotype viruses as tools to identify virus entry inhibitors, PDVI 2nd Asian Regional Dengue Research Network Meeting.. 2005. |