|
Researcher
: Cai Y |
|
Project Title: |
A systematic investigation on novel natural inhibitors of fatty acid synthase from medicinal and dietary plants |
|
Investigator(s): |
Cai Y, Corke H |
|
Department: |
Botany |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
11/2006 |
|
Abstract: |
|
The main objectives of this study are:(1) to systematically investigate and identify novel natural inhibitors of animal fatty acid synthase (FAS) from a large number of bioactive phenolic compounds from medicinal and/or dietary plants; (2) to analyze the structure-activity relationships of the identified novel FAS inhibitors and their kinetic inhibition mechanisms of FAS;(3) to screen potent natural FAS inhibitors as further experimental materials for the development of potential natural chemopreventive and therapeutic agents against cancer.During the last decades, the health-promoting effects of phenolic compounds from dietary and/or medicinal plants have been extensively investigated, such as antioxidant, anticancer, antiatherosclerotic, and antimicrobial activities. Consumption of dietary plants (vegetables, fruits, teas, and spices) and traditional medicinal herbs containing a variety of phenolic compounds has been shown to help prevent many chronic diseases such as cancer and obesity and to reduce the risk of coronary heart disease (a typical example is green/black tea and tea polyphenols) (Tapiero et al 2002; Lin and Lin-Shiau 2006). Much attention has been recently given to the bioactive constituents that are not present in standard oral vitamin supplements, with a particular focus on natural phenolic compounds, widely present in plants. Animal FAS is a key enzyme participating in energy metabolism and is related to chronic diseases such as cancer and obesity (Loftus et al 2000; Kuhajda 2006; Tian 2006). This enzyme is a complex multifunctional enzyme that contains multiple catalytic domains and a phosphopantotheine prosthetic group on a single polypeptide and that catalyzes the reductive synthesis of long-chain fatty acid (palmitate) from the substrates acetyl-CoA, malonly-CoA, and NADPH (Smith et al 2003). It has been found that FAS has low expression in normal human tissues, but it is significantly expressed in a variety of human cancers such as breast, prostate, colon, lung, esophagus, ovary, thyroid, and bladder (Kuhajda 2000, 2006; Lu and Archer 2005). Many recent studies have shown that FAS is a potential therapeutic target for cancer. In addition, animal FAS has also been proposed as a potential target for appetite and weight control (Kuhajda et al 2005; Tian, 2006).The inhibition of animal FAS as a strategy for anticancer and anti-obesity therapies has been receiving much more attention. So far some FAS inhibitors have been reported, such as cerulenin, synthetic C75, orlistat and thiolactomycin (Kuhajda et al 2000; Kridel et al 2004). In particular, some natural polyphenols (e.g., tea polyphenols, some other flavonoids) have been reported to be effective FAS inhibitors (Brusselmans et al 2005; Tian 2006). There has been considerable interest in screening and identifying novel natural FAS inhibitors. As X-ray quality crystals of whole FAS have not been obtained, the precise structure of animal FAS has not been completely elucidated (Smith et al 2003). Thus it is not easy to directly study its inhibition mechanisms and design specific inhibitors. Only a few chemically synthesized FAS inhibitors have been reported. An alternative approach is to identify and screen novel inhibitors of FAS from natural plant sources. However, so far fewer than 20 natural flavonoids have been investigated for the FAS inhibition. More novel natural FAS inhibitors with clear structure and inhibition mechanism and with both reversible and irreversible inhibition are needed. The inhibition of animal FAS as a strategy for anticancer therapies has been emphasized just in the past few years. The effectiveness of animal FAS as an anticancer target needs to be further validated.Additionally, plant-derived tannins, also belonging to plant polyphenols, are commonly divided into condensed tannins and hydrolyzable tannins. They are also widely distributed in dietary and medicinal plants like flavonoids. Natural bioactives tannins are good inhibitors of many enzymes and also potent natural antioxidants (Copeland 2000; Tapiero et al 2002). Nevertheless, there have been few studies on bioactive tannins as FAS inhibitors. |
|
Researcher
: Chan LL |
|
List of Research Outputs |
|
Chan
L.L., Member, International Advisory
Committee, State Key Laboratory of Marine Environmental Science ( |
|
Chan L.L., Lam P.K.S., Sadovy Y.J., Wang D.Z. and Hong H.S., The implication and application of Ciguatera Fishing Poisoning, an invited lecture, Annual Meeting of State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen, 8-9 January, 2007. 2007. |
|
Researcher
: Chow BKC |
|
Project Title: |
Regulation of the human secretin receptor gene |
|
Investigator(s): |
Chow BKC |
|
Department: |
Zoology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2003 |
|
Abstract: |
|
To investigate the interactions of GC motifs within the core promoter region of the hSR gene with Sp1 and Sp3. In addition, the connections between the Sp proteins, cytosine methylation and methylation imprinting will also be studied to elucidate the epigenetic regulation of expression in the hSR gene. |
|
Project Title: |
Mapping of human secretin and its receptor gene expression in human cerebellum |
|
Investigator(s): |
Chow BKC |
|
Department: |
Zoology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2004 |
|
Abstract: |
|
To demonstrate the presence of their transcripts in human cerebellum using real-time quantitative PCR and in situ hybridization, and the localization of secretin peptide by immunohistochemical staining and confocal microscopy. |
|
Project Title: |
A conditional knockout animal model for secretin |
|
Investigator(s): |
Chow BKC, Sham MH |
|
Department: |
Zoology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2005 |
|
Abstract: |
|
To develop an embryonic stem cell-line carrying the floxed secretin gene flanked by loxP sites; to generate secretin null mutant to investigate the physiology of a general secretin KO; to investigate the physiological effects of neuron-specific and Purkinje-specific secretin gene KO. |
|
Project Title: |
Secretin: a putative neurosecretory hormone that regulates water homeostasis in the hypothalamus-pituitary-adrenal axis |
|
Investigator(s): |
Chow BKC, Chan YS, Chung SK |
|
Department: |
Zoology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2006 |
|
Abstract: |
|
To identity the functions of secretin in the hypothalamus and pituitary with a special focus on its potential modulatory role in vasopressin (Vp) synthesis and release; to substantiate the hypothesis that secretin is a neurosecretory hormone released from the posterior pituitary into the systemic circulation; to investigate the function of secretin as an antidiuretic hormone to regulate water reabsorption in the kidney. |
|
Project Title: |
Molecular Evolution of Growth Hormone Releasing Hormone and Its Receptor in non-mammalian species |
|
Investigator(s): |
Chow BKC |
|
Department: |
Zoology |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
01/2006 |
|
Abstract: |
|
1) Clone and functionally characterize
GHRH and its receptor from representative species of fish (zebrafish and/or
goldfish), frog (Xenopus) and bird (chicken).2) Phylogenetic analyses to show
the novel evolutionary scheme of GHRH and its receptor in vertebrates.3)
Provide evidence to show that previously identified GHRHs are in fact only
related peptides.Background:In mammals, GHRH is released from the arcuate
nucleus via the axonal fibers to the hypophysial portal vessels, and is
subsequently delivered to the anterior pituitary where it triggers synthesis
and pulsatile release of GH through the GHRH receptor (GHRHR). In 1982, GHRH
was isolated from human pancreatic islet tumors that caused acromegaly (4-5).
A number of GHRH-like peptides have been characterized from various species,
but, as shown in our phylogenetic study (Fig 1), they are more similar to
mammalian PACAP-related peptides (PRP) rather than mammalian GHRHs. Moreover,
the distributions of these GHRH-like peptides in brain are different when
compared to mammalian GHRHs. Functionally, carp GHRH-like peptide cannot
stimulate GH release in goldfish and carp pituitary cells. These clearly
indicated to us that the "real" GHRHs have indeed never been
characterized in non-mammalian species.Several non-mammalian vertebrate
genomic databases were completely or partially released including avian [Gallus
Gallus (Chicken)], amphibian [Xenopus T. ( |
|
Project Title: |
A negative feedback loop involving bile acids and Small Heterodimer Partner in controlling secretin gene expression is a key to modulate bile release |
|
Investigator(s): |
Chow BKC |
|
Department: |
Zoology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2007 |
|
Abstract: |
|
(1) To substantiate the working model for
regulating secretin gene expression by bile acids in mouse; (2) use secretin
receptor WT and Ko mice to investigate |
|
List of Research Outputs |
|
Tam K.V., Lee T.O. and Chow B.K.C., PACAP-related peptide (PRP)-Molecular evolution and potential functions, Peptides. 2007, 28: 1920-1929. |
|
Researcher
: Corke H |
|
Project Title: |
The diversity of cereal grain products in Hong Kong and southern China |
|
Investigator(s): |
Corke H |
|
Department: |
Botany |
|
Source(s) of Funding: |
Woo Ting Sang Agricultural Development Research Fund |
|
Start Date: |
01/1996 |
|
Abstract: |
|
The cereal industry in this region is
incredibly diverse. There is a vast expansion of diversity fueled by
increasing consumer affluence in |
|
Project Title: |
Behavior of human incisor teeth in relation to sensory appreciation of texture |
|
Investigator(s): |
Corke H, Agrawal KR |
|
Department: |
Botany |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
03/2005 |
|
Abstract: |
|
Introduction People obtain great enjoyment from eating their food. The enjoyment of food is a sensory pleasure that is appreciated from the cradle to the grave. The first bite, which provides a chance for teeth to contact the food, plays a critical role for people to assess the class of food. The incisor teeth used to cut or incise foods are the main agent for biting off a piece of food or cutting into small pieces when necessary. The fundamental mechanical parameters include fracture stress and strain, yield stress, elastic modulus, Poisson’s ratio, coefficient of friction and fracture toughness, which associated with texture in food products, are used to describe the food material characterization. In contrast to mastication, the resistance of a food to an incisal bite will depend basically on the square root of two major food properties, Young’s modulus (elastic modulus) and fracture toughness. For many foods, the quantity should be approximately equal to the product of the stress cracking during a bite and the square root of the length of a notch or indentation from which this crack initiates (index). There are many different kinds of starch-based foods with special good taste and abundant nutrition in Asian. Millions of people in Asian prefer to choose starch-based foods for the major food of their meal as well. To develop an instrumental method predicting the sensory perception of the textural properties of Asian starch-based foods have important significant to meet the need of the consumer’s preference. The aims of this study are to establish the dental variables responsible for variation in the index, and apply the methodology to two food systems – a model system of starch gels with widely varying textural properties and an applied system using a range of noodle formulations. Via simple but fundamentally grounded experiments, applications to both dental and food industry practice can be established. Literature Review The acceptability of many classes of food to consumers is strongly influenced by expectations about food texture. Food texture is defined as “all the rheological and structural (geometric and surface) attributes of product perceptible by means of mechanical, tactile, and, where appropriate, visual and auditory receptors” (Lawless & Heymann, 1998). By this definition, food texture can be evaluated manually. There have been a large number of studies of incision by food scientists in relation to consumer preferences. Perceptions of fracture should be evaluated using teeth and the first bite with the incisors seems particularly critical in formulating opinions (Bourne, 2002). Mechanical elements are often simultaneously investigated by various instruments and then correlations are established between sensory terms and mechanical properties. Most analyses (Meullenet, 2002; Hylander, 1975) have centered on the correlation of psychophysical responses with the mechanical characteristics of foods obtained from tests made with universal testing machines. Significant correlations between a perceived food quality and a mechanical property do not imply a functional relationship. Materials must be homogeneous and isotropic, and be in a geometrical shape such that stresses and strains can be precisely calculated. If only a limited range of foods is offered, their mechanical properties would likely be correlated with each other (Ashby 1998). Any number of nonsensical conclusions might follow, which will only become apparent when predictions subsequently break down on a broader range of foods. However, food scientists have largely ignored the theory of fracture in their mechanical characterizations of starch-based food. There have been many more such studies on other foods, such as cheese, nuts, etc. Applying fracture mechanics, Vincent et al. (2002) found that the critical stress intensity factor, KIC, of foods, a parameter related to crack initiation, was linearly related to perceived measures of ‘hardness’ and ‘crunchiness’ as evaluated by trained ‘taste’ panelists. Vincent et al. suggested that mechanical characterizations of foods founded on sound theoretical support could replace the need for panels of this type since these are simpler and cheaper to run than taste panels and are free from cultural and linguistic limitations. The first bite has been instrumented before (Kohyama & Nishi 1997; Kohyama et al. 2001), but the use of the fracture theory and its potential for characterizing bite efficiency appears firmly linked to J.F.V. Vincent’s pioneering work. So applying the theory of fracture to the mechanical characterization of starch-based foods has very important significance. |
|
Project Title: |
Molecular markers for starch content and quality in rice |
|
Investigator(s): |
Corke H |
|
Department: |
Botany |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
11/2006 |
|
Abstract: |
|
To develop gene-tagged markers and their integration into a genetic linkage map, and mapping OTL for starch content and quality (structural and functional properties); to sequence major genes, analysis of gene diversity and linkage disequilibrium, and association mapping of the genes in relation to starch content and quality; to develop a protocol for marker-assisted selection to most effectively simulate multiple components contributing to high starch contents and desired starch properties in Chinese rice breeding and therefore with direct applicability to economic development in China. |
|
Project Title: |
Effect of ozonation on physical properties and product performance of wheat flour |
|
Investigator(s): |
Corke H, Chan GKY, Phillips DL, Brooks JD |
|
Department: |
Botany |
|
Source(s) of Funding: |
Seed Funding Programme for Applied Research |
|
Start Date: |
01/2007 |
|
Abstract: |
|
Wheat flour usage in |
|
List of Research Outputs |
|
Researcher
: Corlett RT |
|
Project Title: |
Checklist of the vascular plant flora of Hong Kong |
|
Investigator(s): |
Corlett RT |
|
Department: |
Ecology & Biodiversity |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
09/1992 |
|
Abstract: |
|
To produce an accurate checklist of the
vascular plant species occurring in |
|
Project Title: |
Conservation
ranking of |
|
Investigator(s): |
Corlett RT |
|
Department: |
Ecology & Biodiversity |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
01/1994 |
|
Abstract: |
|
To establish an objective system for
ranking terrestrial habitats in |
|
Project Title: |
The use of artificial fruits to assess variation in the probability of seed dispersal by birds |
|
Investigator(s): |
Corlett RT |
|
Department: |
Ecology & Biodiversity |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
07/2005 |
|
Abstract: |
|
Seed dispersal by birds has a major
influence on both plant persistence in forest fragments and forest recovery
in deforested areas. A decade of research in |
|
Project Title: |
Global Climate Change and Ecosystem Responses |
|
Investigator(s): |
Corlett RT, Aitchison JC, Chen J, Dudgeon D, Fang HHP, Gu J |
|
Department: |
Ecology & Biodiversity |
|
Source(s) of Funding: |
Seed Funding for Strategic Research Theme |
|
Start Date: |
08/2005 |
|
Abstract: |
|
The sub-theme will provide a framework to faciliatat inter-disciplinary collaboration within HKU. It will help to offset the dispersion of environmental interests across faculties and the limited intra-University communication. The research sub-theme will leverage HKU's existing research strengths in a variety of HKU departments including Civil Engineering, Earth Science, Ecology & Biodiversity, and Geography. |
|
Project Title: |
Ultraviolet
signals for birds in |
|
Investigator(s): |
Corlett RT |
|
Department: |
Ecology & Biodiversity |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
07/2006 |
|
Abstract: |
|
The visual systems of birds are very different from that of humans. All songbird species (Passerida) that have been tested have tetrachromatic vision, with a fourth cone cell type with maximum sensitivity in the near-UV (355-380 nm) and a visual spectrum spanning 320-700 nm (vs. 400-700 nm in humans). Recent research has shown the importance of UV signals in social life, foraging and predator avoidance, but we have only a fragmentary picture of the role of UV in the life of any one bird species. The aim of this project is to identify the UV signals in the environments of the three best-studied local songbird species, including signals from: other birds of the same species; other bird species with which they form winter flocks; potential foods (fruits, flowers and insects); potential predators; and the background against which these signals appear (leaves, bark, soil etc.). This information will then be used both to reinterpret existing data sets, particularly for diet and flocking behaviour, which were collected in ignorance of information transmitted in the UV spectrum, and in the planning of future studies of bird ecology in Hong Kong and elsewhere. |
|
Project Title: |
Fruit traits and seed dispersal in native and alien plants |
|
Investigator(s): |
Corlett RT |
|
Department: |
Ecology & Biodiversity |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
11/2006 |
|
Abstract: |
|
To compare the fruit traits of native, naturalized, and cultivated alien plants in Hong Kong; to compare the rates of removal by native frugivores of these fruits; to test two predictions: that the fruit traits in those alien species that have become naturalized are more similar to those of the native flora than the fruit traits of aliens that have not become naturalized; and the native frugivores preferentially remove fruits of alien species with fruits traits similar to (or more attractive than) those of the native flora. |
|
List of Research Outputs |
|
Researcher
: Dudgeon D |
|
Project Title: |
Latitudinal comparison of leaf litter breakdown in streams |
|
Investigator(s): |
|
|
Department: |
Ecology & Biodiversity |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
09/2001 |
|
Abstract: |
|
To determine the effects of leaf quality
and characteristics on the breakdown of litter in streams in temperate Europe
and tropical |
|
Project Title: |
The conservation of freshwaters in tropical Asia |
|
Investigator(s): |
Dudgeon D |
|
Department: |
Ecology & Biodiversity |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
01/2002 |
|
Abstract: |
|
To write a book setting out the conservation status of lake and river ecosystems in the oriental tropics, for publication by Backhuys Press in 2004. |
|
Project Title: |
First worldwide aquatic leaf decomposition experiment (WW-DECOEX) |
|
Investigator(s): |
Dudgeon D |
|
Department: |
Ecology & Biodiversity |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
01/2002 |
|
Abstract: |
|
To understand the factors that influence leaf decomposition in streams of different lathitudes, particular the effects of varying leaf palatability to invertebrate shredders. |
|
Project Title: |
The ecology and biodiversity of Hong Kong |
|
Investigator(s): |
Dudgeon D, Corlett RT |
|
Department: |
Ecology & Biodiversity |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
07/2002 |
|
Abstract: |
|
To produce a revised edition of Dudgeon
and Corlett (1994) "Hills and streams: an ecology of |
|
Project Title: |
Tropical stream ecology |
|
Investigator(s): |
Dudgeon D |
|
Department: |
Ecology & Biodiversity |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
01/2003 |
|
Abstract: |
|
To produce a multi-authored volume focused on comparison of streams among tropical regions on a topic-by-topic basis; to summarise what is known by highlighting similarities among regions (particularly the ecological responses to a climatic backdrop of wet versus dry seasons, plus temperature close to the biological optimum), and to account for any consistent patterns of difference that emerge; to highlight what we do not know, and suggest ways of filling these knowledge gaps in a subsection of each chapter entitled 'future research directions and information needs'. |
|
Project Title: |
Conservation of freshwater biodiversity in Asia |
|
Investigator(s): |
Dudgeon D |
|
Department: |
Ecology & Biodiversity |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
06/2003 |
|
Abstract: |
|
To write a book for discussing the issues and implications of damages and pollution causes by human beings. |
|
Project Title: |
Scale-specific
inter-population variation in the proteomics of Caridina shrimps in |
|
Investigator(s): |
Dudgeon D, Chan LL |
|
Department: |
Ecology & Biodiversity |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2004 |
|
Abstract: |
|
To understand whether molecular differences revealed by RAPD are adaptations to local conditions, or merely a reflection of non-adaptive variation, we must study what proteins are actually present in each population. |
|
Project Title: |
Trophic flows across ecosystems and terrestrial-aquatic linkages |
|
Investigator(s): |
Dudgeon D, Zhang Y |
|
Department: |
Ecology & Biodiversity |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
09/2005 |
|
Abstract: |
|
To study ecosystem functional connectivity of trophic flows across riparian forest and stream habitats; to examine the importance of cross-habitat reciprocal subsidies on both stream and riparian food webs. |
|
Project Title: |
An experimental
trial of the feasibility of re-establishing of freshwater animals in |
|
Investigator(s): |
Dudgeon D |
|
Department: |
Ecology & Biodiversity |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
04/2006 |
|
Abstract: |
|
The main objective of this seed grant proposal is to carry out a test of the feasibility of re-establishing self-sustaining populations of two species of freshwater animals to habitats where they have been eliminated by human impacts. If initial trials and post-release monitoring demonstrate that the approach is feasible, then funds to undertake larger-scale re-establishment of local species of conservation importance will be sought from CERG or the Environment and Conservation Fund (HKSAR Government). |
|
Project Title: |
Biodiversity and
ecosystem functioning in |
|
Investigator(s): |
Dudgeon D, Zhang Y |
|
Department: |
Ecology & Biodiversity |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2007 |
|
Abstract: |
|
To establish the functional role of invertebrates associated with leaf litter; to test the relationship between shredder diverstiy and detritus processing rates along a gradient of stream characteristics; to determine the relationship between leaf quality, shredder diversity and detritus processing rates; field studies to determine the effects of changed flow regimes on shredder diversity and detritus processing rates; to use artificial stream channels to determine the effects of shredder diversity, changed flow regimes and water temperature on detritus processing rates; to establishment of the relationship between shredder diversity and detritus processing rates using field microcosms and laboratory experiments. |
|
List of Research Outputs |
|
Researcher
: Jiang P |
|
List of Research Outputs |
|
Jiang P., Ngai H.Y.H., Lee C.L., Sit W.H. and Wan J.M.F., Cellular Proteome Change over Time Induced by Lipopolysaccharide (LPS) in Murine Macrophage Raw 264.7 Cells, 8th World Congress on Inflammation, Demark on 16 - 20 June 2007. 07.25. |
|
Jiang P., Sangild P.T., Thymann T., Ngai H.Y.H., Sit W.H., Chan K.L. and Wan J.M.F., Proteome Profile in Preterm Intestine Following Necrotizing Enterocolitis (NEC), 8th World Congress on Inflammation, Denmark on 16 - 20 June 2007. |
|
Lee C.L., Jiang P., Sit W.H. and Wan J.M.F., Proteome of human T lymphocytes with treatment of cyclosporine and polysaccharopeptide: Analysis of significant proteins that manipulate T cells proliferation and immunosuppression, International Immunopharmacology. 2007, 7: 1311-1324. |
|
Ye
Y., Ngai H.Y.H., Sit W.H., Jiang P. and Wan J.M.F., Effect of Dietary Omega-3
Fatty Acids on Heymann Membranous Nephritis: A Proteomic Assessment, 8th World
Congress on |
|
Researcher
: Kwok HYA |
|
List of Research Outputs |
|
Kwok H.Y.A., Wang Y., Wang C.Y. and Leung F.C.C., Cloning of Chicken Glucocorticold Rceptor (GR) and Characterization of its Expression in Pituitary and Extrapituitary Tissues, Poultry Science Association Inc. 2007, 86: 423-430. |
|
Researcher
: Kwok WHKP |
|
List of Research Outputs |
|
Raisuddin S., Kwok W.H.K.P., Leung K.M.Y., Schlenk D. and Lee J.S., The Copepod Tigriopus: a promising marine model organism for ecotoxicology and environmental genomics, The 5th international Conference on Marine Pollution and Ecotoxicology, 3-6 June 2007, City University of Hong Kong, Hong Kong. 2007. |
|
Researcher
: Lam PKS |
|
List of Research Outputs |
|
Chan L.L., Lam P.K.S., Sadovy Y.J., Wang D.Z. and Hong H.S., The implication and application of Ciguatera Fishing Poisoning, an invited lecture, Annual Meeting of State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen, 8-9 January, 2007. 2007. |
|
Researcher
: Lee TO |
|
Project Title: |
Transcriptional
regulation of a nasopharyngeal carcinoma tumor suppressor: RASSF |
|
Investigator(s): |
Lee TO, Chow BKC |
|
Department: |
Zoology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2004 |
|
Abstract: |
|
To elucidate the basal transcription
regulation mechanisms of RASSFIA in normal - RASSF |
|
List of Research Outputs |
|
Tam K.V., Lee T.O. and Chow B.K.C., PACAP-related peptide (PRP)-Molecular evolution and potential functions, Peptides. 2007, 28: 1920-1929. |
|
Researcher
: Leung FCC |
|
Project Title: |
Cloning of the viral genes from the newly identified SARS coronavirus |
|
Investigator(s): |
Leung FCC |
|
Department: |
Zoology |
|
Source(s) of Funding: |
VCO SARS Research Fund |
|
Start Date: |
07/2003 |
|
Abstract: |
|
To clone all the viral gene into vector and these cloned genes will be then be used as reagents by us and other as the first step for investigation. |
|
Project Title: |
Development of a rapid high throughput RT-PCR assay to detect SARS-CoV |
|
Investigator(s): |
Leung FCC |
|
Department: |
Zoology |
|
Source(s) of Funding: |
VCO SARS Research Fund |
|
Start Date: |
07/2003 |
|
Abstract: |
|
To develop a 96-wells RT-PCR platform assay for the detection of the coronavirus. |
|
Project Title: |
Molecular cloning of the chicken growth hormone receptor and the molecular characterization of the 5'-flanking region |
|
Investigator(s): |
Leung FCC |
|
Department: |
Zoology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
10/2003 |
|
Abstract: |
|
To determine the molecular structure and nucleotide sequence of the chicken GHR gene and the multiple 5' UTR exon 1. |
|
Project Title: |
Isolation and characterization of a PCV2 virus causing postweaning multisystemic wasting syndrome in pigs |
|
Investigator(s): |
Leung FCC |
|
Department: |
Zoology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2003 |
|
Abstract: |
|
To isolate and characterize the PCV2 virus that causes the Postweaning multisystemic wasting syndrome (PMWS) in pigs. |
|
Project Title: |
Severe acute respiratory syndrome (SARS) coronavirus and apoptosis |
|
Investigator(s): |
Leung FCC |
|
Department: |
Zoology |
|
Source(s) of Funding: |
Research Fund for the Control of Infectious Diseases - Full Grants |
|
Start Date: |
01/2005 |
|
Abstract: |
|
The objective of this proposal is to determine and characterize the SARS coronavirus viral genes (S, M, N and E) induced apoptosis and to further identify and characterize the apoptosis epitopes. |
|
Project Title: |
Investigation of the occurrence of penicillium marneffei infections in wild rats in Hong Kong |
|
Investigator(s): |
Leung FCC, Hau CH |
|
Department: |
Zoology |
|
Source(s) of Funding: |
Research Fund for the Control of Infectious Diseases - Mini Grants |
|
Start Date: |
09/2006 |
|
Abstract: |
|
To determine the prevalence of Penicillium marneffei infections in wild rats in Hong Kong; to isolate the Penicillium marneffei from trapped wild rats internal organs (lung, liver, and spleen) from various parts of Hong Kong; to provide data whether bamboo rats exist in Hong Kong and whether they are infected P. marneffei and/or other wild rats species are infected P. Marneffei; to identify possible natural reservoir for P. marneffe. |
|
Project Title: |
Characterization of the angiotensin-converting enzyme 2 receptors from various animals and the use of pseudotyped virus to correlate the receptor-binding to susceptibility of SARS-CoV infection |
|
Investigator(s): |
Leung FCC |
|
Department: |
Zoology |
|
Source(s) of Funding: |
Research Fund for the Control of Infectious Diseases - Full Grants |
|
Start Date: |
01/2007 |
|
Abstract: |
|
To identify the susceptible animals to severe acute respiratory syndrome associated coronavirus SARS-CoV and SARS-like bat CoV through a molecular approach. |
|
List of Research Outputs |
|
Kwok H.Y.A., Wang Y., Wang C.Y. and Leung F.C.C., Cloning of Chicken Glucocorticold Rceptor (GR) and Characterization of its Expression in Pituitary and Extrapituitary Tissues, Poultry Science Association Inc. 2007, 86: 423-430. |
|
Wong T.Y., Hon C.C., Zeng F. and Leung F.C.C., Screening of differentially expressed transcripts in infectious bursal disease virus-induced apoptotic chicken embryonic fibroblasts by using cDNA microarrays, Journal of General Virology. 2007, 88: 1785-1796. |
|
Researcher
: Leung KMY |
|
Project Title: |
Aquatic ecological risk assessment: comparison of tropical and temperate species sensitivity to chemicals |
|
Investigator(s): |
Leung KMY |
|
Department: |
Ecology & Biodiversity |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
09/2002 |
|
Abstract: |
|
To compare the species sensitivity distributions for temperate and tropical organisms exposed to individual chemicals; to identify specific chemical groups, classified by mode of action or physico-chemical properties, for which technically sound estimates of tropical PNECs can be made/predicted on the basis of temperate toxicity data; to validate these predictions through the generation/compilation of extensive ecotoxicity datasets for a number of model substances; to establish a procedure to estimate tropical PNECs for the selected substances. Existing data will be supplemented by new ecotoxicity data where these are likely to result in improved confidence in the estimation of tropical PNECs. |
|
Project Title: |
Ecology, physiology and toxicology of Stomatopoda in Hong Kong |
|
Investigator(s): |
Leung KMY |
|
Department: |
Ecology & Biodiversity |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
09/2002 |
|
Abstract: |
|
To document the biodiversity of Stomatopoda in the subtital marine environment of Hong Kong; to study the population dynamics, ecology and physiology of five commercially important stomatopod species, Harpiosquilla harpax, Dictyosquilla foveolata, Miyakea nepa, Oratosquilla oratoria and Oratosquillina interrupta in the selected study locations; to investigate if there are any seasonally variations in the concentrations of pollutants such as heavy metals, polycyclic aromatic hydrocarbons (PAHs) and polychlorinated biphenyls (PCBs) in the tissues of these five stomatopod species; to test and establish the relationship between fitness parameters, physiological indices and pollution burdens in the stomatopods. |
|
Project Title: |
Fluctuating asymmetry of the Barnacle Tetraclita japonica: influences of shore levels and pollution |
|
Investigator(s): |
Leung KMY |
|
Department: |
Ecology & Biodiversity |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
01/2003 |
|
Abstract: |
|
To determine fluctuating asymmetry (FA) of T. japonica based on the morphological characteristics of their scutum and tergum, with an estimation of measurement errors; to compare the level of FA of T. japonica collected from three different shore levels (low, mid and high) of two polluted sites and two clean sites; to test the relationship between the level of pollutants (e.g. heavy metals) and the degree of FA in T. japonica. The present results will enable us to identify the key factor(s), which affect the FA in T. japonica and answer whether or not FA can be used as a reliable pollution indicator. |
|
Project Title: |
Characterisation of metallothionein-like proteins in marine molluscs induced by metal and non-metal stressors |
|
Investigator(s): |
Leung KMY, Chan LL |
|
Department: |
Ecology & Biodiversity |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
12/2005 |
|
Abstract: |
|
Research BackgroundMetallothioneins (MTs)
are a group of low molecular weight, soluble, cysteine-rich and heat-stable
proteins, which are induced by and bind a variety of trace metals such as Ag,
Cd, Cu, Hg and Zn (Roesijadi 1992; Dallinger et al. 1997). They have
important and unique roles in homeostasis of essential metals (e.g. Zn and
Cu) and detoxification of toxic metals (e.g. Cd and Hg). Correspondingly,
they have been proposed as potential biomarkers for metal contamination in
the aquatic environment. Recently, the Working Group on Biological Effects of
Contaminants (WGBEC) of the International Council for the Exploration of the
Sea (ICES) has recommended MT as one of the priority biomarkers (in fish and
bivalve molluscs) for biomonitoring programmes at national or international
level (ICES, 2003). Over the last five years, the PI has demonstrated that
the concentration of total MTs is a good predictor of bioavailable fractions
of Cu and Cd in the marine gastropods Littorina littorea and Nucella lapillus
(Leung & Furness |
|
Project Title: |
Characterisation of metallothioneins in marine mussels and gastropods induced by metal and non-metal stressors using proteomics |
|
Investigator(s): |
Leung KMY, Wang Y |
|
Department: |
Ecology & Biodiversity |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2007 |
|
Abstract: |
|
To apply advance proteomic techniques to characterise various isoforms of metallothioneins (MTs) in the common biomonitors, Perna viridis (green lipped mussels) and Thais clavigera (rock shells) which are induced by exposure to non-metal stressors including oxidative substances (e.g. hydrogen peroxide) and xenobiotics (e.g. organotin compounds); to compare these non-metal induced MT isoforms with those induced by trace metals such as cadmium and copper based on their properties and amino acid sequences; to investigate the physiological properties (e.g. dose-response, half-life) of the non-metal induced MT isoforms in vivo in the laboratory and in the field. |
|
List of Research Outputs |
|
Researcher
: Lim BL |
|
Project Title: |
Studies on Bacillus phytases |
|
Investigator(s): |
Lim BL |
|
Department: |
Zoology |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
09/2000 |
|
Abstract: |
|
To close the genes of Bacillus phytases; to overexpress Bacillus phytases and to characterize their biochemical properties; to carry out agricultural applications of Bacillus phytases. |
|
Project Title: |
Utilization of soil organic phosphorus by genetically modified plants |
|
Investigator(s): |
Lim BL |
|
Department: |
Zoology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
09/2004 |
|
Abstract: |
|
To confirm whether the enhanced growth performance of the GM line is attributed to the utilization of soil IHIP by the secreted [beta]-propella phytase; to examine whether the GM plants have lower P requriement than the null lines and the wildtype; to examine whether the GM plants can utilized various salt forms of IHPs in soil. (Fe-phytate, Ca-phytate, Al-phytate); to examine the stability and the activity of the secreted phytase in soil ; to compare the abilities of 3 classes of phytases (BPP, HAP and PAP) in hydrolyzing IHP adsorbed to various soil components (A1, Fe and Ca precipitates, clays, etc); to examine the effects of organic acids (citrate, malate, oxalate) on the activities of the three classes of phytases (BPP, HAP and PAP); to create a phytase secreting Arabidopsis line that has elevated citrate acid secretion from root and compare its growth performance with the line that solely secretes phytase. |
|
Project Title: |
Expression and characterization of PAPs 10, 15 and 18 from Arabidopsis thaliana |
|
Investigator(s): |
Lim BL |
|
Department: |
Zoology |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
09/2005 |
|
Abstract: |
|
For many years, plants have been regarded as incapable of assimilating phytate, the major form of organic phosphorus in soil, by their roots. Our recent data showed that wild type tobacco could grow normal in sand culture supplemented with magnesium phytate salts, but not in sand cultures supplemented with Na-phytate, Al-phytate and Mn-phytate. The results implied that plant roots could secrete an enzyme which can hydrolyze Mg-phytate and we postulate it as a member of purple acid phophatase. Genome analysis shows that there are 29 PAP-like genes in the whole genome of Arabidopsis. We carried out a phylogenetic analysis with 50 plant PAP a.a. sequences and grouped them into several subgroups. In this project, 3 representative Arabidopsis PAP genes (AtPAPs 10, 15 and 18) from each subgroups are selected for overexpression in a baculovirus expression system. The enzymes will be purified and their biochemical properties, including substrate specificities, Km, Kcat, pH and temperature profiles, will be studied. Since most of the reported PAPs did not exhibit phytase activity, we wish to verify whether one of these AtPAPs has phytate-hydrolyzing ability. This enzyme will have great potential in agriculture application. The recombinant proteins will also be used to raise specific antisera from rabbits. Our previous works detected phytase activity in plant growth media after growing the plant for 30 days. The activity was presumably secreted from the root. To identify the identity of the phytase secreted from plant root, specific antibodies will be used for western blotting studies and in enzyme inhibition assays. |
|
Project Title: |
Biochemical properties of a bacterial purple acid phosphatase from Burkholderia. |
|
Investigator(s): |
Lim BL, Wong KB |
|
Department: |
Zoology |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
09/2006 |
|
Abstract: |
|
Phytate is the richest organic phosphorus compound in soil. However, soil phytate is not directly available to plants. Several strains of Burkholderia sp. were found to associate with plant roots and were able to promote plant's ability to assimilate external phytate (Unno et al, 2005). Phytase activities were also detected from the culture media of these Burkholderia strains, indicating that they are able to excrete phytases. However, the identity of Burkholderia phytase was still obscure. To date, four classes of phytases have been classified based on their amino acid sequences and reaction mechanisms. They are histidine acid phosphatases (HAP), beta-propeller phytases (BPP), Selenomonas phytase and purple acid phosphatases (PAP). PAP sequences can be found in animals, plants and microbes. With a few exceptions, most of the animal and plant PAPs do not exhibit phytase activty. The whole genomes of several Burkholderia sp. have been sequenced. Among the four classes of known phytases, only a single PAP-like sequence can be identified in each Burkholderia genome. Therefore the phytase acitivity of Burkholderia sp. could either be arisen from this PAP-like gene or from a novel phytase family. In this project, it is our objective to overexpress this Burkholderia PAP and subsequently characterize its biochemical properties. Since no X-ray structure of bacterial PAP has been reported, it is also our objective to crystallize this protein and derive its 3D structure by X-ray analysis. |
|
List of Research Outputs |
|
Lim B.L., Yeung S.L., Cheng C.W. and Hill J.E., Distribution and diversity of phytate-mineralizing bacteria, The ISME (International Society for Microbial Ecology) Journal. 2007, 1: 321-330. |
|
Researcher
: Liu Y |
|
List of Research Outputs |
|
Liu Y.
and Gu J., Enantioselective
degradation of chiral phenylcarboxylates, intermediates of linear
alkylbenzene metabolism, International Conference on Environmental and
Public Health Management: Aquaculture and Environment. December 7-9, 2006.
|
|
Researcher
: Lo CSC |
|
Project Title: |
Identification of proteins targeted for degradation in Arabidopsis thaliana during disease resistance responses |
|
Investigator(s): |
Lo CSC, Lam E |
|
Department: |
Botany |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
10/2003 |
|
Abstract: |
|
To identify targets of Sgt1-mediated protein degradation pathways in Arabidopsis thaliana using the following two approaches; (1) Generation and characterization of 2000 transposon-assisted exon trap lines; (2) 2D-gel electrophoresis/MALDI-TOF based proteomics profiling of Sgt1mutants. |
|
Project Title: |
Functional characterization and metabolic engineering of flavonoid pathways in rice |
|
Investigator(s): |
Lo CSC, Lam E |
|
Department: |
Botany |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
10/2004 |
|
Abstract: |
|
To study: (1) functional characterization of 8 selected homologs of flavonoid structural genes in rice i) complementation of Arabidopsis tt mutants ii) generation and analysis of rice gene suppression mutants. (2) generation of transgenic rice with enhanced and/or novel flavonoid metabolites in endosperm. |
|
Project Title: |
Metabolic
profiling and gene expression analysis of defense pathways in |
|
Investigator(s): |
Lo CSC, |
|
Department: |
Botany |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2006 |
|
Abstract: |
|
To metabolic profiling of infected sorghum plants using LC-MS/MS; to identification of secondary metabolism genes in infected sorghum plants by subtractive hybridization. |
|
Project Title: |
Molecular dissection of the biosynthesis pathway for 3-deoxyanthocyanidins in Songhum |
|
Investigator(s): |
Lo CSC |
|
Department: |
Botany |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2007 |
|
Abstract: |
|
(1) gene expression analysis of flavonoid genes in different sorghum cultivars during anthocyanin and 3-deoxyanthocyanidin biosynthesis; (2) complementation analysis of sorghum flavonoid genes in Arabiodopsis mutants; (3) enzymatic analysis of sorghum dihydroflavonol reductase recombinant proteins. |
|
List of Research Outputs |
|
Project Title: |
Itch is a major ubiquitin E3 ligase in the testis: transcriptional regulation and possible role in the initiation of RNA polymerization |
|
Investigator(s): |
|
|
Department: |
Zoology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2007 |
|
Abstract: |
|
To characterize the signaling pathway, trans-acting elements and cis-acting motifs involved in the cAMP-induced Itch gene expression; to identify the Itch-interacting proteins in Sertoli cells and germ cell nuclei and the functional role of Itch in ubiquitination and gene transcription. |
|
Project Title: |
Identification of subcellular and nuclear interacting partners of JAM-B and JAM-C |
|
Investigator(s): |
|
|
Department: |
Zoology |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
03/2007 |
|
Abstract: |
|
Junctional adhesion molecules (JAMs) are recently identified junction proteins belonging to an immunoglobulin subfamily that are expressed by epithelial and endothelial cells. Various studies have suggested that JAMs have crucial functions in the assembly of tight junctions (TJ) and adherens junctions (AJ), the regulation of cell polarity and the transmigration of lymphocytes. Such multiple roles played by JAMs are different from those of other classic transmembrane junction proteins such as occludin and nectin, that have restricted function on junction dynamics. So far, three JAMs, JAM-A, JAM-B and JAM-C, are positively identified in the testis. JAM-A, -B and -C show distinct localizations and functions in the testis. JAM-A is localized at the blood-testis barrier in the seminiferous epithelium and is associated with ZO-1. It is believed that JAM-A is involved in the formation of tight junctions between Sertoli cells. Different from JAM-A, JAM-B and JAM-C are localized at the adherens junctions between Sertoli cells and spermatids. JAM-B is found in the junctional plaques of Sertoli cells whilst JAM-C is expressed in germ cells at all developmental stages (dioploid premeiotic spermatocytes, round spermatids and elongate spermatids). JAM-C is also localized at the nucleus in undifferentiated germ cells such as premeiotic spermatocytes with yet-to-be identified function. As spermiogenesis proceeds, the localization of JAM-C becomes more confined to the junctional plaques in the spermatid head, suggesting that heterotypic interaction of JAM-B and JAM-C between Sertoli and germ cells is essential for Sertoli-germ cell communication and spermatid differentiation. Recent studies have indicated that JAM could interact with beta2 integrin in Jurkat T cells; and beta2 integrin is a transmembrane protein localized at the junctional plaques of Sertoli cells. In this connection, will transmembrane JAM-C in spermatid interacts with beta2 integrin or other transmembrane proteins in Sertoli cells? Does JAM-B in Sertoli cell interacts with transmembrane proteins (other than JAM-C in germ cells) to facilitate spermatid differentiation? In addition, what are the yet-to-be identified functions of JAM-C in the nucleus? Using gene targeting technique, inactivation of JAM-C in the testis blocks the recruitment of cell polarity complex (PAR6-Cdc42-PKC) at the anterior part of the spermatid head, resulting in the male infertility. These studies clearly illustrated that the proper association of peripheral junction proteins with the transmembrane protein is essential to maintain the integrity of cell junctions for spermatid differentiation. The peripheral junction proteins can also act as an adaptor to link the transmembrane proteins with the cytoskeleton, resulting in the regulation of junction dynamics. It is of interest to identify the peripheral proteins that interact with JAM-B and JAM-C and to unravel their roles in the regulation of junction dynamics between Sertoli and germ cells? To address these questions, we must (i) identify the subcellular interacting partners of JAM-B in Sertoli cells and JAM-C in germ cells at the site of cell-cell contacts; (ii) identify the interacting partners of JAM-C in the nuclei of germ cells, and (iii) investigate the functional significance of those interactions. |
|
List of Research Outputs |
|
Researcher
: Ng SS |
|
List of Research Outputs |
|
Hutchinson N., Davies M.S., Ng S.S. and Williams G.A., Trail following behaviour in relation to pedal mucus production in the intertidal gastropod Monodonta labio (Linnaeus), Journal of Experimental Marine Biology and Ecology. 2007, 349: 313-322. |
|
Researcher
: Pan L |
|
List of Research Outputs |
|
Gu J.,
Zhang R. and Pan L., Plasmid Diversity of
Environmental Vibrio Species Isolated from Coastal Marine Environment in |
|
Pan L.
and Gu J., Characterization of
aerobic bacteria involved in degrading polyethylene glycol (PEG)-3400
obtained using plating and enrichment culture techniques, Journal of
Polymers and the Environment. |
|
Pan L.
and Gu J., Diversity and function of
plasmids in Vibrio species isolated from coastal environments, International
Conference on Environmental and Public Health Management: Aquaculture and
Environment. December 7-9, 2006. |
|
Researcher
: Pointing SB |
|
Project Title: |
Molecular diversity and phylogeography of thermophilic communities within geothermal springs in southeast Asia and the contribution of adaptation and allopatry to diversity |
|
Investigator(s): |
Pointing SB |
|
Department: |
Ecology & Biodiversity |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
09/2005 |
|
Abstract: |
|
To assess molecular diversity of thermophilic microbial mat communities from geothermal locations across a broad biogeographical gradient of latitude and altitude at previously unstudied locations within southeast Asia (plus outgroups in Europe, Japan, New Zealand and the USA); to correlate molecular data with morphological, culture and mat fractionation data; to adopt a whole-community approach with the above that will target domain and dividision level diversity of bacteria and archaea, targeting multiple loci for structural and functional genes; to determine potential niche-determining physico-chemical and climatic conditions at the above geothermal sites and relate these through hierarchical cluster analysis to diversity data; to establish phylogenetic relationships between genotypes within and between communities, using data from several gene loci in order to understand community diversity at each location and phylogeographic relationships between locations; to understand the relative importance of adaptation and genetic drift (allopatry) in thermophilic communities through analysis of phylogenies and environmental factors. |
|
Project Title: |
Structure and
role in substrate stabilization of biological soil crusts in |
|
Investigator(s): |
Pointing SB |
|
Department: |
Ecology & Biodiversity |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
01/2007 |
|
Abstract: |
|
Objectives1. To establish the species
composition of soil crusts in central |
|
List of Research Outputs |
|
Researcher
: Sadovy YJ |
|
Project Title: |
Male induction by social control in a protogynous grouper, Epinephelus coioides: a potentially new application for mariculture |
|
Investigator(s): |
Sadovy YJ, Liu M |
|
Department: |
Ecology & Biodiversity |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
10/2004 |
|
Abstract: |
|
To test the hypothesis that the number of juveniles in a social group influences the direction of sexual differentiation in Epinephelus coioides in captivity; to examine the pattern of gonadal development in Epinephelus coioides through detailed histology. |
|
List of Research Outputs |
|
Chan L.L., Lam P.K.S., Sadovy Y.J., Wang D.Z. and Hong H.S., The implication and application of Ciguatera Fishing Poisoning, an invited lecture, Annual Meeting of State Key Laboratory of Marine Environmental Science, Xiamen University, Xiamen, 8-9 January, 2007. 2007. |
|
Researcher
: Saunders RMK |
|
Project Title: |
Reproductive
biology of Bauhinia (Leguminosae: Caesalpinoideae) in |
|
Investigator(s): |
Saunders RMK, Ramsden L |
|
Department: |
Ecology & Biodiversity |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
07/1997 |
|
Abstract: |
|
A study of the reproductive biology of
local |
|
Project Title: |
Pollination ecology and breeding systems of selected species of annonaceae |
|
Investigator(s): |
Saunders RMK |
|
Department: |
Ecology & Biodiversity |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2002 |
|
Abstract: |
|
To carry out : (a) detailed observations on phenology; (b) observations of pollinators; (c) clarification of the floral mechanism; (d) elucidation of the type of breeding system operating. |
|
Project Title: |
Scientific
contributions to the internationally coordinated flora of |
|
Investigator(s): |
Saunders RMK |
|
Department: |
Ecology & Biodiversity |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2003 |
|
Abstract: |
|
To cataloguing and describing the entire
vascular plant flora of |
|
Project Title: |
Taxonomic monographs of the angiosperm genera Mitrephora and Pseuduvaria (Annonaceae) |
|
Investigator(s): |
Saunders RMK |
|
Department: |
Ecology & Biodiversity |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
12/2003 |
|
Abstract: |
|
To combine classical and phylogenetic systematics with studies into the reproductive biology of selected species; to study (1) a detailed survey of morphological, ultrastructural and anatomical characteristics; (2) the analysis of patterns of variation in these characters, enabling the constuction of robust species-level classifications: (3) phylogenetic analyses of the data, enabling the reconstruction of past evolutionary events and a phylogenetic classification which includes supraspecific taxa; (4) an interpretation of the historical biogeography of both genera; and (5) studies of aspects of reproductive biology, including pollination systems and fruit/seed dispersal. |
|
Project Title: |
Preliminary descriptive and molecular systematics of Uvaria (Annonaceae) as a foundation for a combined morphological and molecular phylogenetics analysis of the genus |
|
Investigator(s): |
Saunders RMK, Su YCF |
|
Department: |
Ecology & Biodiversity |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
02/2005 |
|
Abstract: |
|
This project will not only involve the description of new species, but will also enable a more accurate understanding of structural homology. The present proposal also aims to assist in the selection of appropriate genes and intergenic regions for study, and provide preliminary data to assess their utility. |
|
Project Title: |
Phylogenetics as a unifying concept for the study of the comparative anatomy, systematics, historical biogeography and reproductive biology of the flowering plant genera Desmos and Dasymaschalon (Annonaceae) |
|
Investigator(s): |
Saunders RMK, Su YCF |
|
Department: |
Ecology & Biodiversity |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
10/2005 |
|
Abstract: |
|
Taxonomic monographs of the flowering plant genera Desmos and Dasymaschalon (Annonaceae) will be prepared. The monographs will include several main components, viz: detailed comparative studies of anatomy and ultrastructure; construction of robust species-level classifications based on morphological data; phylogenetic reconstructions using a combination of both morphological and molecular data; empirical studies of historical biogeography, using diverse cladistic and 'event-based' analytical methods; laboratory and field-based research into phenology, pollination ecology and breeding systems; and assessments of the conservation status of all species. Phylogenetic trees will be used as a unifying concept for clarifying structural homologies, defining supraspecific taxa, investigating patterns of historical biogeography, and understanding evolutionary changes in breeding systems. |
|
Project Title: |
Systematics and phylogenetics of Uvaria (Annonaceae) and related genera: an integrated morphological, molecular and ecological approach |
|
Investigator(s): |
Saunders RMK, Su YCF |
|
Department: |
Ecology & Biodiversity |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
12/2006 |
|
Abstract: |
|
(1) analysis of morphology, ultrastructure and anatomy: delimitation of taxonomic characters and preliminary assessment of character homology (based on Uvaria species from western Malesia); (2) Development of a species-level classification of Uvaria species in western Malesia; (3) Gene sequencing and phylogenetic analysis (selected Uvaria species); (4) analysis of phenology and reproductive biology (selected Uvaria species); (5) analysis of species conservation status (for Uvaria species from western Malesia) |
|
List of Research Outputs |
|
Researcher
: Shen P |
|
List of Research Outputs |
|
Gu J.
and Shen P., Infaunal
benthic community of intertidal mudflat at |
|
Shen P., Zhou H., Lai H.Y. and Gu J., Benthic infaunal composition and distribution at an intertidal wetland mudflat, Water, Air and Soil Pollution: Focus. Springer, 2006, 6: 575-581. |
|
Shen P.
and Gu J., Biodiversity and dynamics
of polychaetes in coastal intertidal mudflat of |
|
Shen P.,
Zhou H., Yan Y. and Lai H.Y.,
Ecological pollution stress on benthic infauna macroinfaunal community at the
|
|
Researcher
: Shenoy BD |
|
List of Research Outputs |
|
Shenoy B.D., Jeewon R. and Hyde K.D., Impact of DNA sequence-data on the taxonomy of anamorphic fungi, Fungal Diversity. 2007, 26: 1-54. |
|
Shenoy B.D., Jeewon R., Wenping W.P., Bhat D.J. and Hyde K.D., Ribosomal and RPB2 DNA sequence analyses suggest that Sporidesmium and morphologically similar genera are polyphyletic , Mycological Research. 2006, 110: 916-928. |
|
Researcher
: Sit WH |
|
List of Research Outputs |
|
Jiang P., Ngai H.Y.H., Lee C.L., Sit W.H. and Wan J.M.F., Cellular Proteome Change over Time Induced by Lipopolysaccharide (LPS) in Murine Macrophage Raw 264.7 Cells, 8th World Congress on Inflammation, Demark on 16 - 20 June 2007. 07.25. |
|
Jiang P., Sangild P.T., Thymann T., Ngai H.Y.H., Sit W.H., Chan K.L. and Wan J.M.F., Proteome Profile in Preterm Intestine Following Necrotizing Enterocolitis (NEC), 8th World Congress on Inflammation, Denmark on 16 - 20 June 2007. |
|
Lee C.L., Jiang P., Sit W.H. and Wan J.M.F., Proteome of human T lymphocytes with treatment of cyclosporine and polysaccharopeptide: Analysis of significant proteins that manipulate T cells proliferation and immunosuppression, International Immunopharmacology. 2007, 7: 1311-1324. |
|
Ye
Y., Ngai H.Y.H., Sit W.H., Jiang P. and Wan J.M.F., Effect of Dietary Omega-3
Fatty Acids on Heymann Membranous Nephritis: A Proteomic Assessment, 8th World
Congress on |
|
Researcher
: Tam KV |
|
List of Research Outputs |
|
Tam K.V., Lee T.O. and Chow B.K.C., PACAP-related peptide (PRP)-Molecular evolution and potential functions, Peptides. 2007, 28: 1920-1929. |
|
Researcher
: Tan-Un KC |
|
Project Title: |
Characterization of cytoglobin, a potential biomarker for the diagnosis of human liver fibrosis |
|
Investigator(s): |
Tan-Un KC, Ng IOL |
|
Department: |
Zoology |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
05/2005 |
|
Completion Date: |
12/2006 |
|
Abstract: |
|
The objectives of this project are to 1) use cytoglobin as a biomarker for the diagnosis of human liver fibrosis; 2) identify the regulatory elements that control cytoglobin gene expression in human. |
|
Project Title: |
Quantitation of cytoglobin expression in liver of carbon tetrachloride treated mice |
|
Investigator(s): |
Tan-Un KC |
|
Department: |
Zoology |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
02/2006 |
|
Abstract: |
|
Cytoglobin (Cygb) is a protein first
discovered in fibrotic rat livers (Kawada et al., 2001), and its function is
currently unknown. It binds oxygen reversibly via its heme group (Sawai et
al., 2003). It is expressed in the connective tissues of a wide variety of
organs. We and others have demonstrated its localization in fibroblasts and
in the hepatic stellate cells (HSCs) of the liver (Schmidt et al., 2004 and
our unpublished data). As both types of cells are involved in the synthesis
of the extra-cellular matrix (ECM), we hypothesize that cytoglobin may be
related to the metabolism of ECM molecules. Upon liver injury, the functional
phenotype of HSCs changes from a quiescent retinoid-storing one to a
matrix-synthesizing one. During this trans-differentiation, the production of
extra-cellular matrix molecules e.g. collages types I and III by HSCs,
increases remarkably (Okazaki et al., 2003). Cygb had been shown to be
time-dependently up-regulated during culture of primary HSCs, in the presence
or absence of sera (Nakatani et al., 2004), but its expression pattern in
fibrotic regions in vivo has not been described. The objective of this project
is to demonstrate quantitatively the expression of cytoglobin in fibrotic
lesions of the mouse liver in a time-dependent manner in relation to that of
ECM molecules using laser capture microdissection (LCM). References1. Isao
Okazaki, Yosifumi Ninomiya, Tanikawa Kyuichi, Scott I. Friedman,
Extracellular matrix and the liver: approach to gene therapy, |
|
List of Research Outputs |
|
Chan P.K., Philipsen S. and Tan-Un K.C., The study of sequence configuration and functional impact of the (AC)n(AT)xTy motif in human -globin gene promoter Am. J Hematol 82 (5) 342-8 (2007) , American Journal of Hematology . 2007, 82: 342-348. |
|
Researcher
: Wan JMF |
|
Project Title: |
Effects of tumor necrosis factor-[alpha]TNF-[alpha] on cyclins and related cell cycle proteins expressions in human tumor cell lines as determined |
|
Investigator(s): |
Wan JMF |
|
Department: |
Zoology |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
07/1995 |
|
Abstract: |
|
To investigate: a) the effect of TNF on cyclins: D, E, A, B expression by flow cytometry; b) the effect of TNF on P21, PCNA expression by cytometric studies; c) the effect of TNF on tumor cell lines proliferation and apoptosis studied by flow cytometry. |
|
Project Title: |
The role of free radicals and antioxidants in motor neuron degenerative disease |
|
Investigator(s): |
Wan JMF, Vacca-Galloway LL |
|
Department: |
Zoology |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
07/1995 |
|
Abstract: |
|
There are increasing evidence indicating the involvement of free radicals damage in many chronic diseases such as Parkinson's disease, Alzheimer's disease and neurondegenerative disease. By using a motor neuron degenerative disease mouse model, to investigate the roles of free radicals in the disease process and investigating whether antioxidants such as vitamins E and C can be any therapeutic use by naturalizing the free radicals. |
|
Project Title: |
The effects of antioxidants on small cell lung cancer cell line, NCI-H446 |
|
Investigator(s): |
Wan JMF |
|
Department: |
Zoology |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
09/1995 |
|
Abstract: |
|
Lung cancer is almost certainly the most common cancer in the world today. Over the past several years, work has focused on characterizing the prevention, inhibition and regression of lung cancer by [beta]-carotene, vitamin C and vitamin C which act as antioxidants. This study aims to investigate the antiproliferative potential of [beta]-carotene and retinoids by flow cytometry technology. The data will help us to understand how antioxidants prevent lung cancer formation and progression. |
|
Project Title: |
The effects of different dietary fatty acids on the development of mammary tumors in female fischer 344 rats |
|
Investigator(s): |
Wan JMF |
|
Department: |
Zoology |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
09/1995 |
|
Abstract: |
|
Exciting evidences demonstrated that the quality of dietary fatty acids, especially W-6 and W-3 polyunsaturated fatty acids affect the development of cancers such as the colon, breast, and prostate. This project aims to investigate the effect of saturated, monosaturated W-3, and W-6 polyunsaturated fatty acids on breast cancer cells proliferation by using flow cytometry technology. The data in this study will help us understand the mechanisms involved in more depth. |
|
Project Title: |
To determine the mechanisms of apoptosis of polysaccharide peptide (PSP) in human leukemic cell lines and human normal lymphocytes |
|
Investigator(s): |
Wan JMF |
|
Department: |
Zoology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
09/2003 |
|
Abstract: |
|
To determine the apoptotic pathways of PSP-induced apoptosis in various human leukemic cell eines; to identify the survival pathways in the human normal lymphocytes in response to PSP-induced apoptosis. |
|
Project Title: |
Molecular Structural Determination of Protein-bound Polysaccharide peptide (PSP) isolated from the Chinese Medicinal Mushroom Coriolus versicolor (Cov-1) |
|
Investigator(s): |
Wan JMF, Sze KH, Che CM |
|
Department: |
Zoology |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
05/2006 |
|
Abstract: |
|
Purpose: The goal of this project is to
determine the molecular structure of Cov-1 PSP molecule dervies from the
Chinese Medicine mushroom Yun Zhi. Key Issues: Polysaccharide peptide (PSP)
isolated from the mycelia of fungus Coriolus versicolor (Cov-1 strain) or Yun
Zhi is Chinese Medicine best known for its anticancer and immunomodulatory
properties. PSP is classified as a biological response modifier (Ng TB 1998
review) with the ability to induce gamma-interferon, intelerukin-2
production, T-cell proliferation in cancer patients. A small peptide with a
molecular weight of 16-18 kDa originating from PSP has been produced with
antiproliferative and antitumor activities (Yang et al 1992). We have
recently published the cellular and molecular detailed cell death induction
pathways of PSP on human leukemic cells by flow cytometry (Yang &Wan
2005, Hui and Wan 2005) and cDNA arrays (Zeng, Leung &Wan 2005). The
ability of the Cov-1 PSP to distinguish cancerous cells from non-cancerous
cells as recently determined by us (Yang & Wan 2005) and previously by
others (NT 1998 review), indeed suggesting its uniqueness potential in its
development into anticancer agent. Cov-1 PSP possesses a molecular weight of
approximately 100 kDa. The polysaccharide moiety is a heteropolysaccharide
made up of monosccharides with alpha-1, 4 and beta-1, 3 glucosidic linkages
consisting of glucose, glactose, mannose, xylose, arabinose and trace amount
of rhamnose (NT 1998 review). The polypeptide unit contains glutamic and
aspartic acids as the abundant amino acids. PSP is presently used as
over-the-counter dietary health supplement with multiple health claims such
as anti-cancer, anti-inflammatory, antioxidant, anti-allergic and anti-viral.
Our preliminary work on separation and purification of PSP by HPLC technology
has identified two factions: a small molecular fraction of < 5000 Da and a
macro-molecular fraction of > 5000 Da. The former fraction exhibited
anticancer effect onhuman leukemia and the latter fraction exhibited
immunomodulatory effect on healthy normal human T-lymphocytes. Despite the
promising potentials of PSP, pharmaceumatical industry is not willing to
invest into its therapeutic development unless the molecular structural
information is apparent. It is urgent to identify the molecular structure of
the PSP molecules as soon as possible since this unqiue Cov-1 strain
medicinal mushroom exhibits most promising anticancer and immunomodulatory
properties. The Cov-1 PSP strain is currently in Phase III clinical testing
for anti-cancer properties in |
|
List of Research Outputs |
|
Jiang P., Ngai H.Y.H., Lee C.L., Sit W.H. and Wan J.M.F., Cellular Proteome Change over Time Induced by Lipopolysaccharide (LPS) in Murine Macrophage Raw 264.7 Cells, 8th World Congress on Inflammation, Demark on 16 - 20 June 2007. 07.25. |
|
Jiang P., Sangild P.T., Thymann T., Ngai H.Y.H., Sit W.H., Chan K.L. and Wan J.M.F., Proteome Profile in Preterm Intestine Following Necrotizing Enterocolitis (NEC), 8th World Congress on Inflammation, Denmark on 16 - 20 June 2007. |
|
Lee C.L., Jiang P., Sit W.H. and Wan J.M.F., Proteome of human T lymphocytes with treatment of cyclosporine and polysaccharopeptide: Analysis of significant proteins that manipulate T cells proliferation and immunosuppression, International Immunopharmacology. 2007, 7: 1311-1324. |
|
Ye
Y., Ngai H.Y.H., Sit W.H., Jiang P. and Wan J.M.F., Effect of Dietary
Omega-3 Fatty Acids on Heymann Membranous Nephritis: A Proteomic Assessment, 8th World
Congress on |
|
Researcher
: Wang Y |
|
List of Research Outputs |
|
Kwok H.Y.A., Wang Y., Wang C.Y. and Leung F.C.C., Cloning of Chicken Glucocorticold Rceptor (GR) and Characterization of its Expression in Pituitary and Extrapituitary Tissues, Poultry Science Association Inc. 2007, 86: 423-430. |
|
Researcher
: Williams GA |
|
Project Title: |
Heat shock protein expression profiles in marine intertidal organisms in response to heat stress |
|
Investigator(s): |
Williams GA, Leung KMY |
|
Department: |
Ecology & Biodiversity |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2003 |
|
Abstract: |
|
To optimize heat shock protein detection and quantification in different tissues of intertidal marine invertebrates (barnacles, mussels and limpets); to establish the in situ profile of heat shock protein (hsp) expression with relation to time and temperature; to explore the relevance of chaperone molecules in biogeographical distribution and habitat partitioning of intertidal organisms; to determine the cellular heat shock response of intertidal organisms under controlled laboratory experiments and the relevance of acclimatization in thermotolerance threshold; to test the hypothesis that organisms found at different tidal levels will exhibit different hsp expression profiles; to test the hypothesis that laboratory acclimatization will alter the thermotolerance threshold and hsp expression profiles of organisms. |
|
Project Title: |
Tropical
intertidal community structure: the role of supply-side ecology along the |
|
Investigator(s): |
Williams GA, Chan KK |
|
Department: |
Ecology & Biodiversity |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2006 |
|
Abstract: |
|
To assess the distribution and abundance of Tetraclita squamosa and Tetraclita japonica along the South China coast; to estimate the larval dispersal range of Tetraclita and how genetically distinct are Tetraclita along the South China coast; to determine spatial and temporal patterns of larval supply, settlement and post-settlement mortality of Tetraclita species. |
|
List of Research Outputs |
|
Hutchinson N., Davies M.S., Ng S.S. and Williams G.A., Trail following behaviour in relation to pedal mucus production in the intertidal gastropod Monodonta labio (Linnaeus), Journal of Experimental Marine Biology and Ecology. 2007, 349: 313-322. |
|
Researcher
: Wong AST |
|
Project Title: |
The role of GRP/BiP and MnSOD in BRCA1-mediated breast/ovarian tumor suppression |
|
Investigator(s): |
Wong AST, He Q |
|
Department: |
Zoology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
09/2004 |
|
Abstract: |
|
To elucidate the role of GRP78/BiP and MnSOD in BRCA1-mediated breast and ovarian tumor suppression; to define the direct effect of BRCA1 on the altered expressions of GRP78/BiP and MnSOD by transfection and expression of functional BRCA1 gene in OSE cells; to examine the role of GRP78/BiP and MnSOD overespression in the regulation of apoptosis, cell growth and cell cycle progression, and in protecting cells from external stresses and resistance to cytotoxic drugs in breast and ovarian epithelial cells; to determine the mechanism (signal pathway) by which BRCA1 alters the gene activities of GRP78/BiP and MnSOD. |
|
Project Title: |
p70S6K in human ovarian cancer |
|
Investigator(s): |
Wong AST |
|
Department: |
Zoology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2006 |
|
Abstract: |
|
To determine whether p70S6K plays a specific and direct role in actin reorganization, tumor cell migration and invasion; to determine the mechanism underlying its regulation of the actin cytoskeleton. |
|
Project Title: |
Role of the Met/HGF receptor in the invasive behavior of nasopharyngeal carcinoma cells. |
|
Investigator(s): |
Wong AST |
|
Department: |
Zoology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2006 |
|
Abstract: |
|
Nasopharyngeal carcinoma (NPC) is highly
prevalent in our locality of Southern China and Southeast Asia, where the
incidence is approximately 30-80/100,000 people per year, while it is rare in
most other countries, especially in Europe and North America (incidence below
1/100,000) (1). Most NPC are undifferentiated or poorly differentiated
squamous carcinoma. In addition to its rapid growth behavior, NPC is known to
be highly aggressive and invasive and distant metastasis is more frequent
than most of other head and neck cancers (2). 60-85% of NPC patients already
have metastasis in the regional lymph nodes and distant organs at the time of
diagnosis. These factors account for the high rate of treatment failure
despite the tumor cells' radiosensitivity. Prognosis is poor and the 5-year
survival rate is less than 30%. However, the molecular mechanism of tumor
progression in NPC is largely unknown. Hepatocyte growth factor (HGF) is a
stromal-derived cytokine that regulates mitogenesis, motility and
morphogenesis in a cell type-dependent fashion (3, 4). These different
behaviors are part of a single complex phenomenon, termed invasive growth,
which is involved in several physiological processes and also contributes to
cancer progression. The Met tyrosine kinase, a proto-oncogene, was identified
as the high-affinity receptor for HGF and activation of Met via autocrine,
paracrine, or mutational mechanisms can lead to tumorigenesis and metastasis
(5-7). Overexpression of the Met receptor has been detected in NPC. In
addition, HGF acted as a paracrine factor in NPC development. It was found to
be expressed neither in NPC tissues nor in NPC cell lines, but was abundantly
detected in the interstitial tissues surrounding the tumor (8). Importantly,
the prevalence of abnormal Met expression is higher in metastases than in
primary lesions, and is associated with poor clinical prognosis of NPC (8,
9), suggesting a role for the HGF-Met system in the progression of these
tumors. On HGF stimulation, Met activates downstream signaling pathways such
as the phosphatidyinositol 3-kinase (PI3K)-Akt and the mitogen activated
protein kinase (MAPK) pathways (10-12). These pathways are essential for
mediating biological activities including migration, invasion, cell
spreading/actin reorganization. In addition, HGF-Met signaling can upregulate
the production of matrix metalloproteinases and urokinase that induce the
degradation of extracellular matrices and basement membrane and enhance tumor
invasion and metastasis (13, 14). In this study, we plan to determine the
role of Met overexpression in NPC cell invasion and metastasis. We will
further investigate the mechanism underlying these processes. References: 1.
Spano JP, Busson P, Atlan D, Bourhis J, Pignon JP, Esteban C & Armand JP
2003 Nasopharyngeal carcinomas: an update. European Journal of Cancer 39
2121-2135. 2. Grammatica L, Achille G, Piepoli S & Paradiso A 1999 Early,
late symptoms and histological type of nasopharyngeal carcinoma. Oncology
Reports 6 1395-1398. 3. Comoglio PM & Trusolino L 2002 Invasive growth:
from development to metastasis. Journal of Clinical Investigation 109
857-862. 4. Birchmeier C, Birchmeier W, Gherardi E & Vande Woude GF 2003
Met, metastasis, motility and more. Nature Reviews Molecular Cell Biology 4
915-925. 5. Wang R, Kobayashi R & Bishop JM 1996 Cellular adherence
elicits ligand-independent activation of the Met cell-surface receptor.
Proceedings of the National |
|
List of Research Outputs |
|
Researcher
: Yau CST |
|
Project Title: |
Phylogeography
and population structure of the loliginid squids Uroteuthis (Photologligo) |
|
Investigator(s): |
Yau CST |
|
Department: |
Ecology & Biodiversity |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2006 |
|
Abstract: |
|
The loliginid squids, Uroteuthis
(Photololigo) edulis and U. (P.) chinensis are commercially
important species that dominate cephalopod catches in the |
|
Researcher
: Ye Y |
|
List of Research Outputs |
|
Ye Y., Ngai H.Y.H., Sit W.H., Jiang P. and Wan J.M.F., Effect of Dietary Omega-3
Fatty Acids on Heymann Membranous Nephritis: A Proteomic Assessment, 8th World
Congress on |
|
Researcher
: Yeung SL |
|
List of Research Outputs |
|
Lim B.L., Yeung S.L., Cheng C.W. and Hill J.E., Distribution and diversity of phytate-mineralizing bacteria, The ISME (International Society for Microbial Ecology) Journal. 2007, 1: 321-330. |
|
Researcher
: Yu X |
|
List of Research Outputs |
|
Yu X.
and Gu J., Accumulation and
distribution of trivalent chromium and effects on metabolism of the hybrid
willow Salix matsudana Koidz × alba L., Archives of Environmental
Contamination and Toxicology. |
|
Yu X.
and Gu J., Difference in the
Michaelis-Menten kinetics for different species of maize during cyanide
removal, Ecotoxicology and Environmental Safety. |
|
Yu X.
and Gu J., Hexavalent chromium
induced stress and metabolic responses in hybrid willows, Contamination
Cleanup 07. June 24-27, 2007. |
|
Yu X.
and Gu J., Metabolic responses of
weeping willows to selenate and selenite, 2nd International Symposium on
Trace Elements and Health. June 18-20, 2007. |
|
Yu X.
and Gu J., Uptake, metabolism and
toxicity of methyl tert-butyl ether (MTBE) in weeping willows, Journal of
Hazardous Materials. |
|
Researcher
: Zeng F |
|
List of Research Outputs |
|
Wong T.Y., Hon C.C., Zeng F. and Leung F.C.C., Screening of differentially expressed transcripts in infectious bursal disease virus-induced apoptotic chicken embryonic fibroblasts by using cDNA microarrays, Journal of General Virology. 2007, 88: 1785-1796. |
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