DEPT OF SURGERY
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Researcher
: Au DKK |
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Project Title: |
Electrical tinnitus suppression in hearing-impaired patients |
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Investigator(s): |
Au DKK, Ho WK |
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Department: |
Surgery |
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Source(s) of Funding: |
Small Project Funding |
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Start Date: |
11/2003 |
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Abstract: |
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To evaluate the effectiveness of electrical tinnitus suppression in patients with sensorineural hearing loss; to compare the effectiveness of high versus low electrical stimulation rate in tinnitus suppression. |
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List of Research Outputs |
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Au
D.K.K., Assessment of Audiotory Processing
Disorders, Lecture for the Master in Clinical Audiology Course, |
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Au
D.K.K., Benign paroxysmal positional vertigo,
Metro Daily, |
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Au
D.K.K., Encoding Fine Time Structure with
CSSS: Concept and First Results, The 6th Wullstein Symposium on New Developments
in Hearing Technology, Wurzburg, Germany, 7 - 10 December 2006 . |
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Au
D.K.K., Evaluation of different objective
hearing assessment tools in children, The 7th Hearing International Annual
Meeting, |
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Au
D.K.K., Honorary Audiologist, |
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Au
D.K.K., Invited Lecturer, Hearing Aids,
Education Program for Higher Surgical Trainees, Hong Kong College of
Otorhinolaryngologists, Hong Kong. |
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Au
D.K.K., Invited Lecturer, Vestibular
Assessment, Department of Speech and Hearing Sciences, HKU. |
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Au D.K.K., Invited Lecturer, Vestibular Assessments, Department of Speech and Hearing Sciences, HKU. 2006. |
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Au
D.K.K., Invited Speaker & Workshop
Facilitator, Auditory Evoked Pontentials, The 7th Hearing International
Meeting, Pre-Congress Workshop on Hearing Evaluation, |
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Au
D.K.K., Invited Speaker, AE/BAER/ASSR for
Early Detection of Hearing Loss at Birth, Hong Kong Paediatric Society, |
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Au
D.K.K., Invited Speaker, Assessment of
Balance in Children, Hong Kong Physiotherapy Association Limited, |
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Au
D.K.K., Invited Speaker, Hearing abilities in
teh Elderlies and Hearing Aid Selection, Hong Kong and Kowloon Senior
Citizens' Welfare Association Limited, |
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Au
D.K.K., Invited Speaker, Post Hearing Aid
Fitting Care, Occupational Deafness Compensation Board, |
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Au D.K.K., Member, Health and Rehabilitation Sciences Group, Universitas 21. 2006. |
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Au
D.K.K., Noise-induced Hearing Loss: Potential
Hazards from IPod and MP3, The 7th Hearing International Annual Meeting, |
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Au
D.K.K., Occupational Deafness, Lecture for
Postgraduate Diploma in Occupational Medicine, Department of Community and
Family Medicine, CUHK, Hong Kong. |
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Au
D.K.K., Sessional Chairman, Infant Audiologic
Assessment, The 7th Hearing International Annual Meeting, |
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Au
D.K.K., Sound localization in using BAHA, 2006
Chinese University of Hong Kong ENT Conference, Hong Kong, 10 - 11 November
2006. |
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Au
D.K.K., The Impact of MP3 Players on Hearing
Impairment amongst Young, Press Conference, |
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Au
D.K.K., Vestibular Rehabilitative Therapy, The
7th Hearing International Annual Meeting, |
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Schatzer R., Krenmayr A., Kals M.,
Zierhofer C. and Au D.K.K.,
Strategy for Endocding Fine time Structure: Concept and First Results, The
11th International Conference on Cochlear Implants in Children, |
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Xiao H., Au D.K.K., Hui Y., Chow C.K., Fan Y.W. and Wei W.I., Neurofibromatosis type 2 and auditory brainstem implantation., Chinese Medical Journal. 2007, 120(16): 1456-1459. |
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Researcher
: Au WH |
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List of Research Outputs |
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Au W.H., Yu C., Yung Y.P., Chan W.H., Mah I.S.H. and Man C.W., Audit on extracorporeal shockwave lithotripsy of renal and ureteric stones in Tuen Mun Hospital using Sornier Lithotripter S, Surgical Practice. 2007, 11: 6-11. |
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Ho K.L., Ma K.K., Au W.H., Chu S.S.M. and Tam P.C., Improving prostate cancer detection with an extended 10-core transrectal ultrasound-guided prostate biopsy protocol in a local Chinese population, 12th Annual Scientific Meeting, Hong Kong Urological Association, Hong Kong, 5 November 2006. |
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Tai C.K., Ho K.L., Ma K.K., Au W.H., Chu S.S.M. and Tam P.C., Percent free prostate-specific antigen improves specificity of prostate cancer detection in patients with elevated prostate-specific antigen 4-20ng/ml and non-suspicious digital rectal examination, 12th Annual Scientific Meeting, Hong Kong Urological Association, Hong Kong, 5 November 2006. |
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Researcher
: Cai Q |
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List of Research Outputs |
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Wang X., Luk J.M.C., Garcia-Barcelo M.M., Miao X., Leung P.L., Ho D.W.Y., Cheung S.T., Lam B.Y.H., Cheung C.K.Y., Wong S.Y., Lau S.S.M., So M.T., Yu W.C., Cai Q., Liu K.S.Y., Hui C.K., Lau G., Poon R.T.P., Wong J. and Fan S.T., Liver intestine-cadherin (CDH17) haplotype is associated with increased risk of hepatocellular carcinoma, Clinical Cancer Research. 2006, 12(17): 5248-5252. |
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Wang X., Miao X., Cai Q., Garcia-Barcelo M.M. and Fan S.T., SMYD3 tandem repeats polymorphism is not associated with the occurrence and metastasis of hepatocellular carcinoma in a Chinese population, Experimental Oncology. 2007, 29(1): 71-73. |
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Researcher
: Chan HM |
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List of Research Outputs |
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Chan H.M., The roles of macrophage migration inhibitory factor in human
neuroblastoma development, Thesis, Doctor of Philosophy, The |
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Ren Y., Xie Y., Chan H.M. and Tam P.K.H., Visinin like protein 1 (VILIP-1) enhances neuroblastoma cell migration, 53rd Annual International Congress of the British Association of Paediatric Suregons, Stockholm, Sweden, 18-21 July 2006. |
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Researcher
: Chan JKY |
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List of Research Outputs |
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Ngan E.S.W., Lee K.Y., Sit Y.L.F., Poon H.C., Chan J.K.Y., Sham M.H., Lui V.C.H. and Tam P.K.H., Prokineticin-1 modulates proliferation and differentiation of enteric neural crest cells, Biochimica et Biophysica Acta. 2007, 1773(4): 536-545. |
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Ngan
E.S.W., Lee K.Y., Sit F.Y.L., Chan J.K.Y., Sham M.H., Lui V.C.H. and Tam P.K.H., Roles of Prokineticin |
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Researcher
: Chan KL |
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List of Research Outputs |
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Chan K.L., Laparoscopic repair of recurrent childhood inguinal hernias after open herniotomy, Hernia. 2007, 11: 27-40. |
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Chan K.L., Laparoscopic repair of recurrent childhood inguinal hernias after open herniotomy, In: Schumpelick V & Fitzgibbons RJ (eds), Recurrent hernia: prevention and treatment. Heidelberg, Springer Medizin Verlag, 2007, Chapter 33: 347-351. |
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Chan K.L., Chan H.Y. and Tam P.K.H., Towards zero recurrence rate in laparoscopic inguinal hernia repair for paediatric patients of all ages, The 40th Annual Meeting of the Pacific Association of Paediatric Surgeons together with the Annual Scientific Meeting of the Australasian Association of Paediatric Surgeons, Queenstown, New Zealand, 15-19 April 2007. |
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Chow P.C., Lee S.L., Tang M.H.Y., Chan K.L., Lee C.P., Lam B.C.C. and Tsoi N.S., Management and outcome of antenatally diagnosed congenital cystic adenomatoid malformation of the lung, Hong Kong Medical Journal. 2007, 13(1): 31-39. |
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Hui P.W., Lam T.P.W., Chan K.L. and Lee C.P., Fetus in fetu – from prenatal suspicion to postnatal confirmation. , The 3rd International Scientific Meeting of the International Society of Ultrasound in Obstetrics & Gynaecology, Hong Kong, 25-28 February 2007. |
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Jiang P., Sangild P.T., Thymann T., Ngai H.Y.H., Sit W.H., Chan K.L. and Wan J.M.F., Proteome Profile in Preterm Intestine Following Necrotizing Enterocolitis (NEC), 8th World Congress on Inflammation, Denmark on 16 - 20 June 2007. |
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List of Research Outputs |
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Chan A., Poon R.T.P., Mh K.C., Chan S.C., Yuen W.K., Yeung C., Lo C.M. and Fan S.T., Effect of changing paradigm for management of hepatocellular carcinoma on the long-term survival of patients with hepatocellular carcinoma (Abstract), The 1st Biennial Congress of the Asian-Pacific Hepato-Pancreato-Biliary Association, Fukuoka, Japan, 20 - 23 March 2007. |
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Chan A.C.Y., Lo C.M., Ng K.K.C., Chan S.C. and Fan S.T., Implications for management of Mycobacterium tuberculosis infection in adult-to-adult live donor liver transplantation, Liver International. 2007, 27(1): 81-85. |
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Chan
S.C., 10 Years' Long Service Award, Hospital
Authority, |
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Chan S.C., Chik B., Liu C.L., Lo C.M. and Fan S.T., A decade of right liver adult-to-adult live donor liver transplantation: mid-term outcomes (Abstract), The International Liver Transplantation Society 13th Annual International Congress, Rio de Janeiro, Brazil, 20 - 23 June 2007. |
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Chan S.C., Adult-to-Adult liver donor liver transplantation (Invited Lecture), Macau International Forum 2007 Hepatobiliary and Pancreatic Surgery, Macau, 13 - 16 April 2007. 2007. |
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Chan S.C., Advisor (2004 - present), The Hong Kong Liver Transplant Patients' Association. 2007. |
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Chan
S.C., Associate Consultant, |
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Chan S.C., Donor perspective of right liver adult-to-adult liver donor liver transplantation (Invited Lecture), Department of Liver Surgery and Transplantation, Kobe University Hospital, Kobe University Graduate School of Medical Sciences, Kobe, Japan, 16 August 2006. 2006. |
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Chan S.C., Liu C.L., Lo C.M., Lam B.K.Y., Lee E.W.M. and Fan S.T., Donor quality of life before and after adult-to-adult right liver live donor liver transplantation, Liver Transplantation. 2006, 12(10): 1529-1536. |
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Chan S.C., Donors in right liver adult-to-adult live donor liver transplantation (Invited Lecture), Hong Kong Surgical Forum, Hong Kong, 12 - 13 January 2007. 2007. |
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Chan S.C., Donors in right liver adult-to-adult live donor liver transplantation (Invited Lecture), The 1st Joint Hangzhou / Hong Kong Surgical Convention, Hong Kong, 15 January 2007. 2007. |
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Chan S.C., Fan S.T., Lo C.M. and Liu C.L., Effect of side and size of graft on surgical outcomes of adult-to-adult live donor liver transplantation, Liver Transplantation. 2007, 13(1): 91-98. |
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Chan S.C., Head-to-head comparison of the right and left liver graft in adult-to-adult live donor liver transplantation (Abstract), World Transplant Congress 2006, Boston, U.S.A., 22 - 27 July 2006. |
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Chan
S.C., Hepatitis B prophylaxis after live
donor liver transplantation. Hong Kong experience (Invited Lecture), Transplantation
Symposium, |
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Chan
S.C., Live donor liver transplantation in
Hong Kong (Invited Lecture), Meeting of the |
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Chan S.C. and Fan S.T., Live liver donor mortality (Letter to the Editor), Liver Transplantation. 2006, 12(9): 1437. |
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Chan
S.C., Long-term outcome of adult-to-adult
liver donor liver transplantation (Invited Lecture), The Transplantation
Society New Key Opinion Leader Meeting 2006, |
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Chan S.C., Member of Liver Donation Committee (2007 - 2008), Liver Foundation. 2007. |
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Chan S.C., Reviewer, American Journal of Transplantation. 2007. |
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Chan S.C., Reviewer, Asian Journal of Surgery. 2007. |
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Chan
S.C., Reviewer, |
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Chan S.C., Reviewer, Journal of Gastroenterology and Hepatology. 2007. |
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Chan S.C., Reviewer, Journal of Gastrointestinal Surgery. 2007. |
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Chan S.C., Reviewer, Liver International. 2007. |
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Chan S.C., Reviewer, Liver Transplantation. 2007. |
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Chan S.C., Reviewer, World Journal of Surgery. 2007. |
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Chan S.C., Right liver live donor liver transplantation technique (Invited Lecture), The International Hepato-Pancreato-Biliary Association Meeting, Wu Han, China, 14 - 17 October 2006. 2006. |
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Chan S.C., Fan S.T., Lo C.M., Liu C.L. and Wong J., Toward current standards of donor right hepatectomy for adult-to-adult live donor liver transplantation through the experience of 200 cases, Annals of Surgery. 2007, 245(1): 110-117. |
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Chan
S.C., Travelling Award, The International
Liver Transplantation Society 13th Annual International Congress, |
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Chan S.C., Fan S.T., Liu C.L., Lo C.M., Lam B.K.Y. and Lee E.W.M., Working up donors for high-urgency and elective adult-to-adult live donor liver transplantation, Liver Transplantation. 2007, 13(4): 509-515. |
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Hui C.K., Cheung W.W.W., Chan S.C., Lo C.M. and Lau G., Hepatitis B vaccination and preemptive treatment of hepatitis B virus in liver transplantation, Current Opinion in Organ Transplantation. 2006, 11(6): 594-598. |
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Lo C.M., Liu C.L., Chan S.C., Lam C.M., Poon R.T.P., Ng I.O.L., Fan S.T. and Wong J., A randomized, controlled trial of postoperative adjuvant interferon therapy after resection of hepatocellular carcinoma, Annals of Surgery. 2007, 245(6): 831-842. |
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Lo C.M., Lau G., Chan S.C., Fan S.T. and Wong J., Efficacy of a pre-S containing vaccine in patients receiving lamivudine prophylaxis after liver transplantation for chronic hepatitis B, American Journal of Transplantation. 2007, 7(2): 434-439. |
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Lo C.M., Fan S.T., Liu C.L., Chan S.C., Ng I.O.L. and Wong J., Living donor versus deceased donor liver transplantation for early unresectable hepatocellular carcinoma, British Journal of Surgery. 2007, 94(1): 78-86. |
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Researcher
: Chan SM |
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List of Research Outputs |
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Chen M., Lee C.P., Lam Y.H., Chan S.M. and Tang M.H.Y., Chinese fetal renal pelvis measurements at 12-14 weeks of gestation, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, 25-28 February, 2007. |
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Researcher
: Chan VSF |
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List of Research Outputs |
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Chan V.S.F., Chau S.Y., Tian L., Chen Y., Kwong S.K.Y., Quackenbush J., Dallman M., Lamb J. and Tam P.K.H., Sonic hedgehog promotes CD4+ T lymphocyte proliferation and modulates the expression of a subset of CD28-targeted genes, International Immunology. 2006, 18(12): 1627-1636. |
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Researcher
: Chan VWM |
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List of Research Outputs |
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Chan
V.W.M., Luk
J.M.C. and Fan S.T., LI-cadherin
(CDH17)/beta-catenin pathway is involved in tumor proliferation and
metastatic potentials of hepatocellular carcinoma, Hepatology. 2006,
44(4): |
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Luk
J.M.C., Chan V.W.M. and Fan S.T., Cadherin |
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Researcher
: Chan WMV |
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List of Research Outputs |
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Chan W.M.V., Functional characterization of liver intestine-cadherin (CDH17)
in hepatocellular carcinoma, Thesis, Master of Philosophy, The |
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Researcher
: Chan YC |
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List of Research Outputs |
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Chan Y.C., Ting A.C.W., Ho P., Poon J.T.C., Yiu W.K. and Cheng S.W.K., Supra-aortic hybrid endovascular procedures for complex thoracic aortic disease (Best Paper Session), Conjoint Scientific Congress of the Royal College of Surgeons of England and the College of Surgeons of Hong Kong, Hong Kong, 6-7 May 2007. |
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Chan Y.C., Ting A.C.W., Poon J.T.C., Yiu W.K., Cheung G.C.Y. and Cheng S.W.K., Ten year epidemiological review of in-hospital patients with Marfan syndrome, Conjoint Scientific Congress of the Royal College of Surgeons of England and the College of Surgeons of Hong Kong, Hong Kong, 6-7 May 2007. |
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Researcher
: Chau KL |
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List of Research Outputs |
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Lee K.W., Poon R.T.P., Yuen P.W., Ling M.T., Kwok W.K., Wang X., Wong Y.C., Guan X.Y., Man K., Chau K.L. and Fan S.T., Twist overexpression correlates with hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition, Clinical Cancer Research. 2006, 12(18): 5369-5376. |
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Researcher
: Chau SY |
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List of Research Outputs |
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Chan V.S.F., Chau S.Y., Tian L., Chen Y., Kwong S.K.Y., Quackenbush J., Dallman M., Lamb J. and Tam P.K.H., Sonic hedgehog promotes CD4+ T lymphocyte proliferation and modulates the expression of a subset of CD28-targeted genes, International Immunology. 2006, 18(12): 1627-1636. |
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Researcher
: Chen Y |
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Project Title: |
TGF-beta signaling in rat gut ischemia reperfusion injury |
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Investigator(s): |
Chen Y, Lui VCH, Tam PKH |
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Department: |
Surgery |
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Source(s) of Funding: |
Seed Funding Programme for Basic Research |
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Start Date: |
02/2006 |
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Completion Date: |
01/2007 |
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Abstract: |
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Gut ischemia reperfusion: The gut mucosa
serves as the first line of both nutrition absorption and innate defense.
Disruption of blood supply causes damages to the gut mucosa and its
underlining tissues in surgical procedures such as abdominal aortic aneurysm
surgery, cardiopulmonary bypass, and intestinal transplantation, or in
pathological conditions such as strangulated hernias and neonatal necrotizing
enterocolitis. Ischemic conditions due to interrupted blood supply result in
hypoxic injury to the gut. Paradoxically, restoration of blood flow in
reperfusion of the ischemic gut may lead to further tissue damage
(reperfusion injury). Gut ischemia reperfusion injury (IRI) is not only
restricted to local sites, but also can lead to remote organ damage or
systematic inflammation such as sepsis or multi organ failure (MOF). Although
IRI injury occurs in only a small proportion (1-2%) of gastrointestinal
diseases, the mortality from IRI-associated complications is alarmingly high
(60-80%). The disease therefore warrants further study. Pathological changes
associated with gut IRI involve an increase of gut permeability, shortening
of villi, bleeding, and bacteria translocation. Shortening of villi is
accompanied by the sloughing of enterocytes and loss of globlet cells which
exposes the underlining blood capillary of the villi to gut bacteria and
greatly increases the risk of sepsis development. The mechanisms involved in
this phenomenon have not yet been determined, but reactive oxygen spices
(ROS) formation and release during reperfusion may be an important factor.
Pro-inflammatory cytokines such as IL-1 and TNF-alpha also contribute to the
gut IRI process. Intestinal macrophages - resident macrophages (rMphi):
Inflammatory cells such as mast cells, polymorphonuclear neutrophils (PMN)
and platelets have been implicated in gut IRI. Recently, gut rMphi have also
been shown to be important in gut IRI injury. The gut is one of the biggest
reservoirs of macrophages in the body and the mucosa lining is the largest
body surface linked to the external environment. The symbiosis of the gut
bacteria within the gut is maintained by the innate immune system which is
composed mainly of rMphi. They are derived from blood monocytes after
infiltration into the gut and display a characteristic phenotype in that they
do not express many innate receptors including the receptor to bacteria LPS
(CD14) but possess phagocytic and bacteriocidal activity. Their restricted
reactivity to bacteria limits mucosa inflammatory responses in normal
intestinal mucosa. The lack of responsiveness of rMphi is mainly mediated by
the regulation of TGF-beta signaling. It is not known if stimuli such as
hypoxia or stress which affect local TGF-beta production may reverse this
unresponsiveness and activate rMphi, with consequent tissue damage. TGF-beta
signaling: Transforming growth factor-beta (TGF-beta) is a multifunctional
cytokine involved in the regulation of proliferation, differentiation,
migration, and survival of many different cell types. Three TGF-beta isoforms
have been identified in mammals, TGF-beta1, 2 and 3, some of whose functions
overlap. TGF-beta is secreted in a latent form, which requires activation by
proteases or thrombospondin before it can bind to its specific receptors.
Seven type I and five type II serine/threonine kinase receptors, also termed
as Activin-receptor-like kinases (ALKs), have been identified for TGF-betas
in vertebrates. After ligand binding and activation of type I receptors,
signals are then transduced from the membrane to the nucleus via
intracellular effectors, termed Smads (include receptor regulated Smads: Smad
1, 3, 5 and 8; Smad 4 and inhibitory Smads: Smad 6 and 7). The complexity of
TGF-beta signaling is signified by differential cellular responses dependent
on different cell-types and TGF-beta concentrations. In addition, cellular
responses of TGF-beta also depend on other signal transduction pathways,
which can either synergize or antagonize the TGF-beta signal. In line with
the complexity of TGF-beta signaling, macrophages can be activated or
de-activated by TGF-beta. For instance, TGF-beta deactivates sodium caseinate
activated peritoneal rMphi and reduces the release of H2O2. However, the
roles of TGF-beta in the activation and/or deactivation of gut rMphi and the
maintenance of the unresponsive state of gut rMphi in IRI have not been
investigated. Purpose: To investigate the role of TGF-beta signaling pathway
in gut ischemia reperfusion injury (IRI) Work done by the PI: Our published
work has shown that gut rMphi play an important role in the initiation of
IRI. Pathological changes characteristic of IRI were evident in the gut well
before the infiltration of PMN. In addition, depletion of rMphi by
intraperitoneal injection of chlodronateliposome greatly reduced gut IRI.
Preliminary data Typical progress of gut enterocytes sloughing was observed
in our gut IRI model. To investigate the involvement of TGF-beta in gut IRI,
rats were treated with anti-TGF-beta antibody before IR challenge. Isotype
antibody injection rats were used as controls. The preliminary data showed
that anti-TGF-beta antibody treated rats displayed severe enterocytes
sloughing and marked villi blunting and shortening. In contrast, only mild
damage in the isotype injection controls was observed. The degree of villi
sloughing in the isotype control was much less than in the anti-TGF-beta
treatment group (12% ±7% versus 45.5%±7% n= |
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Project Title: |
Identification of macrophages subpopulations in chronic rejection in rat cardiac transplantation model |
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Investigator(s): |
Chen Y, Tam PKH |
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Department: |
Surgery |
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Source(s) of Funding: |
Seed Funding Programme for Basic Research |
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Start Date: |
01/2007 |
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Abstract: |
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Cardiac transplantation is a life saving
strategy in heart failure syndromes and its success depends on the control of
graft rejection. The development of immunosuppressive drugs reduced acute
rejection caused graft lost lower than 10%1. However, 3 to 5 % per year of
cardiac transplantation will further develop chronic rejection (CR)1.
Therefore, effective control CR is crucial for long term graft survival.
Pathologically, the CR is characterized by coronary allograft vasculopathy
(CAV) and parenchymal fibrosis, and CAV has thought to be the major cause of
CR2. CAV was composed by fibrosis, arteritis and atheroma of blood vessels
contribute to the thickening of vessels in the allograft. Eventually, intimal
thickening is detectable with intracoronary ultrasound (ICUS) in up to 75% of
patients at first year after transplantation3. Regardless of the initiating
events the pathology begins with a fibrogenesis phase, consisting of
inflammatory and proliferative responses, which are regulated by cytokines,
chemokines and growth factors. These processes lead to the matrix
accumulation phase, due to either increased production and/or reduced
degradation of matrix. Mechanism of chronic rejection: Both
non-antigen-dependent and antigen-dependent factors have been implicated in
CR. Antigen-dependent factors which are the primary cause of CR are divided
into three main categories. (i) Alloantibody-mediated rejection.
Alloantibodies production in CR has not been investigated in detail but may
relate to cell-mediated rejection; (ii) Cell-mediated rejection: This occurs
primarily through the activity of CD4+ (helper) T-cells and macrophages, but
not CD8+ (cytotoxic) T cells and natural killer cells. (iii) Tissue
remodeling is influenced by the types and levels of cytokines and growth
factors present in the graft. Macrophages in transplantation and fibrosis
formation: Macrophages present within the allografts are derived both from
tissue macrophages of donor origin and those of recipient origin that have
infiltrated the graft. The deleterious effects of macrophage in AR are well
documented, and depletion of tissue macrophages reduce tissue damage.
However, the functional phenotypes of macrophage in CR are unclear.
Macrophages are involved in disease processes leading to fibrosis formation4
e.g. in carbon tetrachloride (CCl4) rat liver fibrosis model5 depletion of
macrophages reduces fibrotic changes during the induction phase. In contrast,
matrix degradation is reduced and severe fibrosis is observed if macrophages
are depleted during the recovery period. Taken together these data suggest
that functionally distinct macrophage subpopulations are involved in injury
and repair in liver fibrosis. Therefore, heterogeneous subpopulations of
macrophages could play important roles in different stages of CR in which
fibrosis of graft is a hallmark. Heterogeneity of the macrophages in
transplantation: The functional heterogeneity of T cells is well documented
and the effects of polarized T cell populations (Th1 and Th2) in acute and
chronic rejection have been extensively analysed. In contrast, macrophage
heterogeneity has only been recognised recently (reviewed by Gordon. S et
al)6. Broadly, two categories of macrophages namely alternative activated
macrophage (aa-M) and classical activated macrophage (ca-M) have been
proposed depending on the modes of activation7. In ca-M, the macrophages are
activated by Th1 cytokines, bacterial and fungal cell wall components, or
degraded matrix, proinflammatory cytokines and chemokines and are predominantly
lytic to matrix components8,9. In contrast, aa-M are mainly activated by Th2
cytokines, including IL-4 and IL-13 as well as apoptotic cells and
corticosteroids, and produce anti-inflammatory cytokines including IL-10 and
TGF-β promoting matrix deposition10. However, these phenotypes have only been
defined in culture models and may not reflect the complexity of macrophage
function in vivo. Th2 cytokines include IL-4, IL-10 and IL-13 have been shown
to be critical in the development CR11. Immunosuppressive treatment reduces
Th1 cytokines production preventing AR, but the treatment tips the balance of
Th1/Th2 cytokines towards Th2, which while prolonging graft survival also
favours the development of CR11,12. As ca-M and aa-M are selectively
activated by Th1 and Th2 cytokines, it is possible that a transit of ca-M to
aa-M as predominant macrophage type may signify progression from the acute to
the chronic phase of graft rejection. Such a switch of macrophage type could
imply an alteration of function from tissue destruction in AR to tissue
remodeling in CR. Furthermore, in the later stage of CR, an increase in ca-M
could resolve fibrosis and ameliorate tissue damage through direct production
of MMPs or indirectly regulation of fibroblast function. The investigation of
macrophage heterogeneity will provide novel information on the mechanisms of
CR and potential opportunities of selective manipulation of macrophage
subsets in the treatment of CR. References: 1. Libby P, Pober JS 2001.
Immunity 14:387-397 2. Kaye MP 1993. J Heart Lung Transplant 12:541-548 3.
Costanzo MR, Naftel DC, Pritzker MR, et al. 1998. J Heart Lung Transplant
17:744-753 4. Wynn TA 2004. Nature reviews 4:583-594 5. Duffield JS, Forbes
SJ, Constandinou CM, et al. 2005. J Clin Invest 115:56-65 6. Gordon S, |
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List of Research Outputs |
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Chan V.S.F., Chau S.Y., Tian L., Chen Y., Kwong S.K.Y., Quackenbush J., Dallman M., Lamb J. and Tam P.K.H., Sonic hedgehog promotes CD4+ T lymphocyte proliferation and modulates the expression of a subset of CD28-targeted genes, International Immunology. 2006, 18(12): 1627-1636. |
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Chen Y., Li X., Tian L., Lui V.C.H., Dallman M.J., Lamb J.R. and Tam P.K.H., Inhibition of sonic hedgehog signaling reduces chronic rejection and prolongs allograft survival in a rat orthotopic small bowel transplantation model, Transplantation. 2007, 83(10): 1351-1357. |
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Chen Y., Liu Y., Yuan Z., Tian L., Dallman M.J., Thompson P.W., Tam P.K.H. and Lamb J.R., Rosiglitazone suppresses cyclosporin-induced chronic transplant dysfunction and prolongs survival of rat cardiac allografts, Transplantation. 2007, 83(12): 1602-1610. |
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Chen
Y., Kam
C.S.K., Lui V.C.H. and Tam P.K.H., TGF-B blockade aggravates
gut ischemia reperfusion injury via activation of resident macrophages, 53rd
Annual International Congress of the British Association of Paediatric
Surgeons, |
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Chen Y., The role of dendritic cells in epstein-barr virus infection, Thesis, Doctor of Philosophy. 2006. |
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Liu Y., Lei L., Lui E.L.H., Lau C.P.Y., Chen Y., Wo Y.H., Fan S.T. and Poon R.T.P., Tyrosine kinase inhibitor PTK 787/ZK222584 inhibits liver fibrosis (Abstract), The 17th Asian Pacific Association for the Study of the Liver Conference, Kyoto, Japan, 27 - 30 March 2007. Hepatology International. 2007, 1(1): 206. |
|
Researcher
: Chen Y |
|
List of Research Outputs |
|
Chan V.S.F., Chau S.Y., Tian L., Chen Y., Kwong S.K.Y., Quackenbush J., Dallman M., Lamb J. and Tam P.K.H., Sonic hedgehog promotes CD4+ T lymphocyte proliferation and modulates the expression of a subset of CD28-targeted genes, International Immunology. 2006, 18(12): 1627-1636. |
|
Chen Y., Li X., Tian L., Lui V.C.H., Dallman M.J., Lamb J.R. and Tam P.K.H., Inhibition of sonic hedgehog signaling reduces chronic rejection and prolongs allograft survival in a rat orthotopic small bowel transplantation model, Transplantation. 2007, 83(10): 1351-1357. |
|
Chen Y., Liu Y., Yuan Z., Tian L., Dallman M.J., Thompson P.W., Tam P.K.H. and Lamb J.R., Rosiglitazone suppresses cyclosporin-induced chronic transplant dysfunction and prolongs survival of rat cardiac allografts, Transplantation. 2007, 83(12): 1602-1610. |
|
Chen
Y., Kam
C.S.K., Lui V.C.H. and Tam P.K.H., TGF-B blockade aggravates
gut ischemia reperfusion injury via activation of resident macrophages, 53rd
Annual International Congress of the British Association of Paediatric
Surgeons, |
|
Chen Y., The role of dendritic cells in epstein-barr virus infection, Thesis, Doctor of Philosophy. 2006. |
|
Liu Y., Lei L., Lui E.L.H., Lau C.P.Y., Chen Y., Wo Y.H., Fan S.T. and Poon R.T.P., Tyrosine kinase inhibitor PTK 787/ZK222584 inhibits liver fibrosis (Abstract), The 17th Asian Pacific Association for the Study of the Liver Conference, Kyoto, Japan, 27 - 30 March 2007. Hepatology International. 2007, 1(1): 206. |
|
Researcher
: Chen Y |
|
List of Research Outputs |
|
Chan V.S.F., Chau S.Y., Tian L., Chen Y., Kwong S.K.Y., Quackenbush J., Dallman M., Lamb J. and Tam P.K.H., Sonic hedgehog promotes CD4+ T lymphocyte proliferation and modulates the expression of a subset of CD28-targeted genes, International Immunology. 2006, 18(12): 1627-1636. |
|
Chen Y., Li X., Tian L., Lui V.C.H., Dallman M.J., Lamb J.R. and Tam P.K.H., Inhibition of sonic hedgehog signaling reduces chronic rejection and prolongs allograft survival in a rat orthotopic small bowel transplantation model, Transplantation. 2007, 83(10): 1351-1357. |
|
Chen Y., Liu Y., Yuan Z., Tian L., Dallman M.J., Thompson P.W., Tam P.K.H. and Lamb J.R., Rosiglitazone suppresses cyclosporin-induced chronic transplant dysfunction and prolongs survival of rat cardiac allografts, Transplantation. 2007, 83(12): 1602-1610. |
|
Chen
Y., Kam
C.S.K., Lui V.C.H. and Tam P.K.H., TGF-B blockade aggravates
gut ischemia reperfusion injury via activation of resident macrophages, 53rd
Annual International Congress of the British Association of Paediatric
Surgeons, |
|
Chen Y., The role of dendritic cells in epstein-barr virus infection, Thesis, Doctor of Philosophy. 2006. |
|
Liu Y., Lei L., Lui E.L.H., Lau C.P.Y., Chen Y., Wo Y.H., Fan S.T. and Poon R.T.P., Tyrosine kinase inhibitor PTK 787/ZK222584 inhibits liver fibrosis (Abstract), The 17th Asian Pacific Association for the Study of the Liver Conference, Kyoto, Japan, 27 - 30 March 2007. Hepatology International. 2007, 1(1): 206. |
|
Researcher
: Cheng LC |
|
List of Research Outputs |
|
Tsang F., Law S.Y.K., Chau W.S., Chiu S.W.C. and Cheng L.C., A man with hemoptysis 3 years after bronchial stenting, CHEST 2006 the 72nd Annual International Scientific Assembly of the American College of Chest Physicians (ACCP), Salt Lake City, Utah, USA, 21-26 October 2006. |
|
Researcher
: Cheng Q |
|
List of Research Outputs |
|
Cheng Q., Man K., Ng T.P., Lo C.M., Poon R.T.P. and Fan S.T., The significance of hepatic stellate cell activation on small-for-size fatty liver graft injury (Abstract), The International Liver Transplantation Society 13th Annual International Congress, Rio de Janeiro, Brazil, 20 - 23 June 2007. |
|
Man K., Xiao J., Ng T.P., Cheng Q., Sun B., Wang Y., Sun K.W., Poon R.T.P. and Lo C.M., Adiponectin as a novel therapy for the suppression of the liver cancer growth and metastasis (Paper Presentation), the 14th European Organisation for the Research and Treatment of Cancer, National Cancer Institute, and American Association for Cancer Research (EORTC-NCI-AARC) Symposium on Molecular Targets and Cancer Therapeutics, Prague, Czech Republic, 7 - 10 November 2006. European Journal of Cancer Supplement. 2006, 50. |
|
Man K., Xiao J., Ng T.P., Cheng Q., Sun K.W., Lo C.M., Poon R.T.P. and Fan S.T., Combination therapy for liver tumor growth and metastasis by low dose rapamycin and FTY720 (Paper Presentation), the 14th European Organisation for the Research and Treatment of Cancer, National Cancer Institute, and American Association for Cancer Research (EORTC-NCI-AARC) Symposium on Molecular Targets and Cancer Therapeutics, Prague, Czech Republic, 7 - 10 November 2006. |
|
Man K., Ng T.P., Xu A.M., Cheng Q., Sun B., Sun K.W., Lee K.W., Lo C.M., Poon R.T.P. and Fan S.T., Fat-derived hormone adiponectin suppresses liver tumor growth and metastases (Paper Presentation), The 98th Annual Meeting of the American Association for Cancer Research, Los Angeles, USA, 14 - 18 April 2007. |
|
Ng T.P., Man K., Cheng Q., Sun B., Lee K.W., Poon R.T.P., Lo C.M. and Fan S.T., Suppression of tumorigenesis and metastasis of hepatocellular of hepatocellular carcinoma by shRNA interference targeting on inhibition of homeoprotein Six1 (Paper Presentation), The 98th Annual Meeting of the American Association for Cancer Research, Los Angeles, USA, 14 - 18 April 2007. |
|
Researcher
: Cheng SWK |
|
Project Title: |
Endovascular program for treating thoracic aortic dissections |
|
Investigator(s): |
Cheng SWK, Ting ACW |
|
Department: |
Surgery |
|
Source(s) of Funding: |
S.K. Yee Medical Foundation - General Award |
|
Start Date: |
04/2004 |
|
Abstract: |
|
To initiate medical services for the poor and sick in the field of endovascular treatment of aortic dissections and provide equipment for such services. |
|
Project Title: |
Study of the
pathological significance of COX |
|
Investigator(s): |
Cheng SWK, Cheuk LY |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
01/2005 |
|
Completion Date: |
12/2006 |
|
Abstract: |
|
The main objectives of this project are: 1) To test the hypothesis that vascular infection may induce vascular cell loss, which is dependent on the inflammatory COX-2 gene expression; 2) To determine whether COX-2 inhibitor has potential therapeutic value as an anti-apototic agent. |
|
Project Title: |
Molecular expression of fibulin-1and matrix metalloproteinases (MMPs) in Type A aortic dissection |
|
Investigator(s): |
Cheng SWK, Cheuk LY, Cheng LC |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
01/2007 |
|
Abstract: |
|
Aortic dissection is a life-threatening
disease with separation of the layers within the aortic wall. Traditional
treatment of Type A aortic dissection usually require surgery, but the
morbidity and mortality remain unsatisfactory. Previously, most aortic
dissection was diagnosed premortem or postmortem because many patients die
before presentation to the emergency department. Pathological studies have
demonstrated that aortic dissection is usually associated with
atherosclerotic hypertensive disease of aorta and is initiated by an intimal
tear followed by the rapid growth of an intramural haematoma that dissects the
media. Acute aortic dissection patients are also characterized by solube
elastin fragments elevated in serum probably due to the degeneration of
elasin by MMPs within the aortic walls (1, 2). The freshly torn aorta is
severely weakened and may rupture. Elastin, is an extracellular matrix
protein found in aortas imparting elasticity to connective tissue. It is
secreted as tropoelastin, a soluble protein that is cross-linked in the
tissue space to form an insoluble elastin matrix. Cross-linked elastin can be
found in association with several microfibril-associated proteins including
fibrillin-1, fibrillin-2 and fibulin-1 suggesting that these proteins
contribute to aorta structural integrity by elastic fiber assembly, structure
or function. Elastin fiber is also important to permit the elastic recoil
that is necessary for the aorta to absorb pulse pressure (3). Matrix
metalloproteinases (MMPs) are responsible for the elastolysis. `Clinical data
have suggested that tissue remodelling involving metalloproteinases (MMPs) in
dissection of aorta is important (1,2), but the pathological significance of
degeneration of elastin within dissected aortic wall remains poorly
understood. Fibulins are a newly recognized family of extracellular matrix
proteins. The five known members of the family share an elongated structure
and many calcium-binding sites, owing to the presence of tandem arrays of
epidermal growth factor-like domains. They have overlapping binding sites for
several basement-membrane proteins, tropoelastin, fibrillin, fibronectin and
proteoglycans and expressed in the basement membrane of blood vessels
abundantly (4). Fibulin-1 appears to be essential for polymerization of
elastin that binds to tropoelastin. Thus, the tropoelastin cannot be
assembled into mature elastin fibrils without the functional fibulin-1 (4).
In adult blood vessels, pronounced fibulin 1 deposition occurs in the matrix
that surrounds VSMCs and in the elastic laminae of arteries (5). Fibulin 1
deficiency in mice causes extensive haemorrhaging and perinatal death (6).
The study has also shown that patients with unstable angina pectoris and
acute myocardial infarction have significantly reduced levels of plasma
fibulin 1 (7). This has led to speculation that plasma fibulin 1 may be
transferred to or consumed in or around the atherosclerotic lesion. Indeed,
fibulin 1 is incorporated into fibrin clots that are associated with
atherosclerotic lesions (8). Findings from DNA microarray studies showed that
fibulins 1 is consistently associated with matrix metalloproteinase 2 (MMP-2)
expression (9). Altered patterns of fibulin-1 and MMPs gene expression
suggest a pre-existing structural failure of the aortic wall, may resulting
in dissection. Despite a general consensus that the remodeling of the elastin
and collagen is indispensable for the explanation of structure alteration of
dissected aortic walls, attempts to induce such dramatic remodeling of matrix
protein via fibulin-1 gene remain elusive. We propose an original study to
delineate the significance of fibulin-1 and the related metalloproteinase in
dissected aortic tissue using molecular biological approaches. The concept
underpinning this approach is built on our preliminary work, which
demonstrated that the dissected aortic walls exhibit a down-regulation of
fibulin-1 mRNA (see figure 1,last page) which specifically alter the elastin
assembly. In the present study, we hypothesize that fibulin-1 expression is
reduced in patients with Type A aortic dissection and its reduction may
correlates with fragmentation of elatic fibers due to the enhanced specific
metalloproteinases, like MMP-2. We expect this study can provide information
on the pathogenesis of acute Type A aortic dissection. The inhibition of
aberrant expression of fibulin gene and the related proteinases may open new
avenue for preventing aortic dissection. Specific objectives (1) Determine
the elastin content, fibulin-1 and MMPs in Type A aortic dissection surgical
samples and compare with that of control aortas (2) Localizing the fibulin-1
and MMPs immunohistochemically and (3) Investigate the relationships of
expression of fibulin-1 and MMPs in diseased aortas by studying the
difference of those proteins between diseased and control aorta thus may
explain, at least in part, might be predisposed to develop aortic dissection.
References: 1. Shinohara T, Suzuki K, Okada M, Shiigai M, Shimizu M, Maehara
T, Ohsuzu F. Soluble elastin fragments in serum are elevated in acute aortic
dissection. Arterioscler Thromb Vasc Biol. 2003; 23: 1839-1844. 2. Rao SK,
Mathrubutham M, Sherman D, Cereira J, Cohen JR. Reduced capacity to inhibit
elastase in abdominal aortic aneurysm. J Surg Res 1999; 36: 241-251. 3.
Burton AC. Relation of structure to function of the tissues of the wall of
blood vessels. Physiol Rev 1954; 34: 619-642. 4. Timpl R, Sasaki T, Kostka G,
|
|
Project Title: |
A prospective randomized trial of endovascular stent graft repair versus best medical treatment for patients with acute Type B aortic dissection |
|
Investigator(s): |
Cheng SWK, Tse HF, Ting ACW, Cheng LC |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2007 |
|
Abstract: |
|
To evaluate the short term efficacy of endovascular stent grafting for acute type B aortic dissections compared to medical treatment in terms of 30-day mortality; to determine if endovascular stent graft for acute type B aortic dissection will have fewer complications compared to medical treatment; to test whether stent grafting for type B dissections will lead to early false lumen thrombosis and less aneurysm formation compared with medical treatment on the long term; to compare the effects on long term mortality between stent grafting and medical treatment for type B dissections. |
|
List of Research Outputs |
|
Chan Y.C., Ting A.C.W., Ho P., Poon J.T.C., Yiu W.K. and Cheng S.W.K., Supra-aortic hybrid endovascular procedures for complex thoracic aortic disease (Best Paper Session), Conjoint Scientific Congress of the Royal College of Surgeons of England and the College of Surgeons of Hong Kong, Hong Kong, 6-7 May 2007. |
|
Chan Y.C., Ting A.C.W., Poon J.T.C., Yiu W.K., Cheung G.C.Y. and Cheng S.W.K., Ten year epidemiological review of in-hospital patients with Marfan syndrome, Conjoint Scientific Congress of the Royal College of Surgeons of England and the College of Surgeons of Hong Kong, Hong Kong, 6-7 May 2007. |
|
Cheng
S.W.K., Chairman, Debate on Bypass procedure
remained the treatment of choice for infrapopliteal occlusive disease, The
7th International Congress of the Asian Society for Vascular Surgery, |
|
Cheng
S.W.K., Chairman, Session on "Taming the
Challenges in Vascular Surgery", Hong Kong Surgical Forum, |
|
Cheng
S.W.K., Challenges for thoracoabdominal
endografting, 11th Joint Shanghai/Hong Kong Surgical Convention, |
|
Cheng
S.W.K., Challenges for thoracoabdominal
endografting, Hong Kong Surgical Forum, |
|
Cheng
S.W.K., Current status of EVAR in |
|
Cheng S.W.K., Current status of vascular surgery and its training in Hong Kong, The 35th Annual Meeting of Japanese Society for Vascular Surgery, Nagoya, Japan, 23-25 May 2007. 2007. |
|
Cheng
S.W.K., Debate: Against on Endovascular
aneurysm repair should not be the first choice of treatment for abdominal
aortic aneurysm in the Asian population (Invited Debate), The 7th
International Congress of the Asian Society for Vascular Surgery, |
|
Cheng S.W.K., Difficult neck and difficult iliac: When to say 'No', The 7th International Congress of the Asian Society for Vascular Surgery, Kuala Lumpur, Malaysia, 16-19 August 2006. 2006. |
|
Cheng S.W.K., Editor (2002 - present), Annals of the College of Surgeons of Hong Kong. 2007. |
|
Cheng S.W.K., Editor-in-Chief (2003 - present), Asian Journal of Surgery. 2007. |
|
Cheng
S.W.K., Endovascular and hybrid techniques
for treatment of thoracic aneurysms and dissection, |
|
Cheng S.W.K., Endovascular management of pseudoaneurysms, UCSF Vascular Symposium 2007, 26-28 April 2007, San Francisco, USA. 2007. |
|
Cheng S.W.K., Endovascular treatment of thoracic aortic diseases, Conjoint Scientific Congress of The Royal College of Surgeons of Edinburgh & The College of Surgeons of Hong Kong, Hong Kong, 10-13 October 2006. 2006. |
|
Cheng S.W.K., Invited Co-Chairman, Surgery in the future , Conjoint Scientific Congress of The Royal College of Surgeons of Edinburgh & The College of Surgeons of Hong Kong, Hong Kong 10-13 October 2006. 2006. |
|
Cheng
S.W.K., Invited to discuss the latest
developments in EVAR technology, The 2007 Master Class Endoluminaries, |
|
Cheng S.W.K., Member (1996 - present), Editorial Board, Chinese Journal of Vascular Surgery. 2007. |
|
Cheng
S.W.K., Member (2002 - present), Editorial
Board, Cutting Edge, |
|
Cheng
S.W.K., Serena Yang Professor in Vascular
Surgery (April 2005 - present), Endowed Professorship, The |
|
Cheng
S.W.K., Technical challenges of endovascular
aortic stent grafting, The 66th Scientific Meeting of the |
|
Cheng S.W.K., The 61st Vascular Annual Meeting of the Society of Vascular Surgery, Baltimore, Maryland, USA, 7-10 June 2007. 2007. |
|
Cheng S.W.K., The 92nd Annual Clinical Congress of the American College of Surgeons, Chicago, USA, 8-12 October 2006. 2006. |
|
Cheng
S.W.K., The Endoluminaries Program
conjunction with the 33rd Annual VEITH |
|
Cheng
S.W.K., The applications of vascular surgery,
The 2nd Certificate Course in Recent Medical Advances for General Practitioners,
Hong Kong Sanatorium & Hospital, |
|
Cheng S.W.K., The role of endovascular treatment of critical limb, Dinner Symposium: Peripheral Arterial Disease - The Silent Killer, The College of Surgeons of Hong Kong, Hong Kong, 9 August 2006. 2006. |
|
Cheng
S.W.K., To conduct a peripheral vascular
workshop (Invited Workshop), |
|
Cheng
S.W.K., Valiant Thoracic Physician
Training Course, |
|
Cheng
S.W.K., When and how to preserve the internal
iliac artery?, The 7th International Congress of the Asian Society for
Vascular Surgery, |
|
Cheng
S.W.K., When to consider endovascular repair
v. open surgery for Pre-congress Workshop on "Endovascular Stent for
Aortic Aneurysm and Dissection", The 7th International Congress of
the Asian Society for Vascular Surgery, |
|
Cheuk L.Y., Lau S.F. and Cheng S.W.K., Carotid intima-media thickness in patients with abdominal aortic aneurysms, European Journal of Vascular and Endovascular Surgery. 2007, 33(2): 149-153. |
|
Ho P., Cheng S.W.K., Ting A.C.W., Poon J.T.C. and Liu L.H.L., Hybrid endovascular operation for ruptured thoracic aortic aneurysm (Case report), Hong Kong Medical Journal. 2007, 13(1): 78-80. |
|
Itani K.M., Morris P.J., Macias F.C., Bevilacqua R.G., Cheng S.W.K., Ladipo J.K. and Brennan M.F., Training of a surgeon: an international perspective, Journal of American College of Surgeons. 2007, 204(3): 478-485. |
|
Rhee S.Y., Guan H., Liu Z.M., Cheng S.W.K., Waspadji S., Palmes P., Tai T.Y., Suwanwalaikorn S. and Kim Y.S., Multi-country study on the prevalence and clinical features of peripheral arterial disease in Asian type 2 diabetes patients at high risk of atherosclerosis, Diabetes Research and Clinical Practice. 2007, 76(1): 82-92. |
|
Ting A.C.W., Cheng S.W.K., Ho P. and Poon J.T.C., Endovascular stent graft repair for infected thoracic aortic pseudoaneurysms - a durable option?, Journal of Vascular Surgery. 2006, 44(4): 701-705. |
|
Ting A.C.W. and Cheng S.W.K., Images in vascular medicine. Pseudoaneurysm as a result of peripheral arterial stent infection, Vascular Medicine. 2006, 11(3): 171-172. |
|
Yiu W.K., Cheng S.W.K. and Sumpio B.E., Vascular smooth muscle cell apoptosis induced by "supercooling and rewarming, Journal of Vascular and Interventional Radiology. 2006, 17(12): 1971-1977. |
|
Researcher
: Cheng WC |
|
List of Research Outputs |
|
Lui V.C.H., Cheng W.C., Leon Y.Y., Lau K.C., Garcia-Barcelo M.M., Miao X., Wall N. and Tam P.K.H., HOXB5 regulates the expression of RET in ENS: a novel Hirschsprung's gene, The 40th Annual Meeting of the Pacific Association of Paediatric Surgeons together with the Annual Scientific Meeting of the Australasian Association of Paediatric Surgeons, Queenstown, New Zealand, 15-19 April 2007. |
|
Researcher
: Cheuk LY |
|
List of Research Outputs |
|
Cheuk L.Y., Lau S.F. and Cheng S.W.K., Carotid intima-media thickness in patients with abdominal aortic aneurysms, European Journal of Vascular and Endovascular Surgery. 2007, 33(2): 149-153. |
|
Researcher
: Cheung CKY |
|
List of Research Outputs |
|
Lam S.P., Lau C.K., Cheung C.K.Y., Man K., Luk J.M.C. and Lo C.M., Potential use of mesenchymal stem cells (MSCs) treatment in D-Galactosamine induced acute liver failure model, American Jouarnal of Transplantation. 2007, 7: 323-323. |
|
Luo Y., Lo C.M., Cheung C.K.Y., Lau G., Fan S.T. and Wong J., Identification of hepatitis B virus-specific lymphocytes in human liver grafts from HBV-immune donors, Liver Transplantation. 2007, 13(1): 71-79. |
|
Wang X., Luk J.M.C., Garcia-Barcelo M.M., Miao X., Leung P.L., Ho D.W.Y., Cheung S.T., Lam B.Y.H., Cheung C.K.Y., Wong S.Y., Lau S.S.M., So M.T., Yu W.C., Cai Q., Liu K.S.Y., Hui C.K., Lau G., Poon R.T.P., Wong J. and Fan S.T., Liver intestine-cadherin (CDH17) haplotype is associated with increased risk of hepatocellular carcinoma, Clinical Cancer Research. 2006, 12(17): 5248-5252. |
|
Researcher
: Cheung CM |
|
List of Research Outputs |
|
Cheung C.M., Tang J.C.O., Lee P.Y., Hu L., Guan X.Y., Srivastava G., Wong J., Luk J.M.C. and Law S.Y.K., Establishment and characterization of a new xenograft-derived human esophageal squamous cell carcinoma cell line HKESC-4 of chinese origin, 11th Research Postgraduate Symposium (11th RPS), The University of Hong Kong Li Ka Shing Faculty of Medicine, Hong Kong, 7 December. 2006. |
|
Researcher
: Cheung PSY |
|
List of Research Outputs |
|
Chan W.F., Cheung P.S.Y., Mak J. and Epstein R., Multidisciplinary approach
to the management of breast cancer in |
|
Leung A.W., Mak J., Cheung P.S.Y. and Epstein R., Clinicopathologic correlates
in a cohort of |
|
Project Title: |
Characterization of the granulin/epithelin precursor gene in liver cancer |
|
Investigator(s): |
|
|
Department: |
Surgery |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
09/2003 |
|
Abstract: |
|
To characterize the role of the granulin/epithelin precursor (GEP) gene in the development and progression of liver cancer: 1) to examine the abnormalities of the GEP gene in normal, diseased and tumor specimens of the liver; 2) to understand the clinical and pathological significance of the GEP gene: to study the growth and proliferation function of the GEP gene in liver cancer; to identify the GEP regulated genes/pathways in liver cancer. |
|
Project Title: |
Functional role
of DNALI |
|
Investigator(s): |
|
|
Department: |
Surgery |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
05/2006 |
|
Abstract: |
|
Background: Dynein, axonemal, light
intermediate polypeptide 1 (DNALI1) is the human homolog of the Chlamydomonas
inner dynein arm gene, p28. The precise function of this gene is not known,
however, it is a potential candidate for immotile cilia syndrome (ICS).
Ultrastructural defects of the inner dynein arms are seen in patients with
ICS. Immotile mutant strains of Chlamydomonas, a biflagellated algae, exhibit
similar defects (SOURCE, provided by Genetics Department, |
|
Project Title: |
GEP as a novel molecular target for liver cancer therapy |
|
Investigator(s): |
|
|
Department: |
Surgery |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
09/2006 |
|
Abstract: |
|
(1) To examine the prospective of GEP as therapeutic target, and the efficacious of GEP antibody to inhibit tumor growth with cell lines: liver cancer and normal liver cell lines with different GEP levels will be studied. Cells will be treated with GEP monoclonal antibody, and examined the efficiency of inhibition on proliferation rate, invasion ability, and tumorigenicity; (2) to investigate the potential of targeted cancer therapy for liver cancer with animal models: athymic nude mice model will be used. To examine the treatment on established tumors, GEP monoclonal antibody will be applied when the tumors have reached certain size. |
|
Project Title: |
Circulating biomarkers in liver cancer: cell and cell-free fraction analysis |
|
Investigator(s): |
|
|
Department: |
Surgery |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
03/2007 |
|
Abstract: |
|
Background / Key issues / Problems being addressed: Earlier reports on circulating cancer contents were mostly assays on circulating cancer cells, and controversial data on the diagnostic and prognostic values were presented [1-4]. Recently, extracellular-based assays (circulating cell-free nucleic acid) were found to be as efficacious as, or better than, cell-based assays (circulating cancer cells) in the detection of pre-neoplastic lesions and micrometastasis [5]. We have reported the global gene expression profiles of human liver samples, and genes differentially expressed in the tumor tissues demonstrated the potential for serving as disease markers and therapeutic targets [6-13]. Recently, we have shown that one of these biomarkers, transcript AA454543 (GenBank Accession No. BC043195), is detectable in patients' plasma [9]. Similar to the findings derived from tumor tissues of hepatocellular carcinoma (HCC), we found that patients with a high preoperative plasma transcript AA454543 RNA levels (based on quantitative RT-PCR) were associated with poor disease-free and overall survival post-hepatectomy. By multivariate analysis, plasma transcript AA454543 RNA level was one of the independent risk factors for prediction of overall and disease-free survival for HCC patients who underwent partial hepatectomy [9]. Nonetheless, the actual loading of cancer cells in relation to the measurable quantity in the plasma (containing circulating cancer-derived nucleic acid) and blood cell (containing circulating cancer cells) fractions were not known. Futhermore, whether delay in blood processing for isolation of plasma and blood cell fractions will affect the quantitative data is not clear. Importantly, whether the quantitative data from plasma and blood cell fractions would correlate with the size of tumor burden and metastasis has not been defined. In the current study, we will perform in vitro and in vivo experiments to resolve these concerns. Objectives:1. With artificial in vitro experiments to examine the association of cancer cell loading in relation to the quantitative PCR data in plasma and blood cell fraction, in respect to the delay in blood sample processing. 2. Using animal models to examine the association of cancer cell loading in relation to the quantitative PCR data in plasma and blood cell fraction, in respect to the time-lag of cancer cell injection into the circulation. 3. Intrahepatic tumor model will be used to examined the association of tumor size and metastasis in relation to the quantitative PCR data obtained in the plasma and blood cell fractions. |
|
List of Research Outputs |
|
Cheung S.T. and Fan S.T., Association of gene polymorphism and expression level in liver cancer (Abstract), The 8th International Meeting on Human Genome Variation and Complex Genome Analysis, Hong Kong, 14 - 16 September 2006. |
|
Cheung S.T., Fan S.T., Lee Y.T., Ng I.O.L. and Lo C.M., Biomarker in relation to post-transplant recurrence in liver cancer patients (Abstract), The 2nd Nanjing-Hong Kong Liver Transplantation Symposium, Nanjing, China, 25 - 27 August 2006. |
|
Cheung
S.T., Biomarker in relation to
post-transplant recurrence in liver cancer patients (Invited Lecture), The
2nd Nanjing-Hong Kong Liver Transplantation Symposium, |
|
Cheung S.T., Member of Editorial Board (Janurary 2006 - present), Chinese Journal of Medicine. 2007. |
|
Cheung S.T., Liu C.L., Chow J.P.H., Lee Y.T., Ip Y.C., Ho J.C.Y. and Fan S.T., Preoperative plasma transcript AA454543 level is an independent prognostic factor for hepatocellular carcinoma after partial hepatectomy, Neoplasia. 2006, 8(9): 696-701. |
|
Cheung S.T., Ho J.C.Y. and Fan S.T., The use of granulin-epithelin precursor (GEP) antibodies for detection and suppression of hepatocellular carcinoma, United States Provisional Patent. No. 60/861,318, 28 November 2006. 2006. |
|
Chua M.S., Sun H., Cheung S.T., Mason V., Higgins J., Ross D.T., Fan S.T. and So S., Overexpression of NDRG1 is an indicator of poor prognosis in hepatocellular carcinoma, Modern Pathology. 2007, 20(1): 76-83. |
|
Ho J.C.Y., Cheung S.T., Poon W.S., Lee Y.T., Ng I.O.L. and Fan S.T., Down-regulation of retinol binding protein 5 is associated with aggressive tumor features in hepatocellular carcinoma, Journal of Cancer Research and Clinical Oncology. 2007. |
|
Ho J.C.Y., Cheung S.T., Patil M.A., Chen X. and Fan S.T., Increased expression of glycosyl-phosphatidylinositol anchor attachment protein 1 (GPAA1) is associated with gene amplification in hepatocellular carcinoma, International Journal of Cancer. 2006, 119(6): 1330-1337. |
|
Ip Y.C., Cheung S.T. and Fan S.T., Atypical localization of membrane type 1-matrix metalloproteinase in the nucleus is associated with aggressive features of hepatocellular carcinoma, Molecular Carcinogenesis. 2007, 46(3): 225-230. |
|
Lau C.P., Poon R.T.P., Cheung S.T., Yu W.C. and Fan S.T., SPARC and Hevin expression correlate with tumour angiogenesis in hepatocellular carcinoma, Journal of Pathology. 2006, 210(4): 459-468. |
|
Liu C.L., Fan S.T., Cheung S.T., Lo C.M., Ng I.O.L. and Wong J., Anterior approach versus conventional approach right hepatic resection for large hepatocellular carcinoma: a prospective randomized controlled study, Annals of Surgery. 2006, 244(2): 194-203. |
|
Wang X., Luk J.M.C., Garcia-Barcelo M.M., Miao X., Leung P.L., Ho D.W.Y., Cheung S.T., Lam B.Y.H., Cheung C.K.Y., Wong S.Y., Lau S.S.M., So M.T., Yu W.C., Cai Q., Liu K.S.Y., Hui C.K., Lau G., Poon R.T.P., Wong J. and Fan S.T., Liver intestine-cadherin (CDH17) haplotype is associated with increased risk of hepatocellular carcinoma, Clinical Cancer Research. 2006, 12(17): 5248-5252. |
|
Researcher
: Chiu SW |
|
List of Research Outputs |
|
Li
G.R., Sun H., Chiu S.W. and Lau C.P., The n-3 polyunsaturated fatty
acids from fish oil inhibit transient outward and ultra-rapid delayed
rectifier potassium currents and voltage-gated sodium current in human atrial
myocytes, CardioRhythm-2007/Europace, |
|
Researcher
: Choi HK |
|
List of Research Outputs |
|
Chik B., Law W.L. and Choi H.K., Urinary retention after haemorrhoidectomy: impact of stapled haemorrhoidectomy, Asian Journal of Surgery. 2006, 29(4): 233-237. |
|
Choi H.K., Law W.L. and Ho J.W.C., Leakage after resection and intraperitoneal anastomosis for colorectal malignancy: analysis of risk factors, Diseases of the Colon and Rectum. 2006, 49(11): 1719-1725. |
|
Law W.L., Choi H.K., Lee Y.M., Ho J.W.C. and Seto C.L., Anastomotic leakage is associated with poor long-term outcome in patients after curative colorectal resection for malignancy, Journal of Gastrointestinal Surgery. 2007, 11: 8-15. |
|
Law W.L., Lee Y.M., Choi H.K., Seto C.L. and Ho J.W.C., Impact of laparoscopic resection for colorectal cancer on operative outcomes and survival, Annals of Surgery. 2007, 245(1): 1-7. |
|
Law W.L., Lee Y.M., Choi H.K., Seto C.L. and Ho J.W.C., Laparoscopic and open anterior resection for upper and mid rectal cancer: an evaluation of outcomes, Diseases of the Colon and Rectum. 2006, 49(8): 1108-1115. |
|
Law W.L., Choi H.K., Lee Y.M. and Ho J.W.C., The impact of postoperative complications on long-term outcomes following curative resection for colorectal cancer, Annals of Surgical Oncology. 2007, 14(9): 2559-2566. |
|
Lo O.S.H., Law W.L., Choi H.K., Lee Y.M., Ho J.W.C. and Seto C.L., Early outcomes of surgery for small bowel obstruction: analysis of risk factors, Langenbeck's Archives of Surgery. 2007, 392(2): 173-178. |
|
Researcher
: Chow CK |
|
List of Research Outputs |
|
Xiao H., Au D.K.K., Hui Y., Chow C.K., Fan Y.W. and Wei W.I., Neurofibromatosis type 2 and auditory brainstem implantation., Chinese Medical Journal. 2007, 120(16): 1456-1459. |
|
Researcher
: Chow JPH |
|
List of Research Outputs |
|
Cheung S.T., Liu C.L., Chow J.P.H., Lee Y.T., Ip Y.C., Ho J.C.Y. and Fan S.T., Preoperative plasma transcript AA454543 level is an independent prognostic factor for hepatocellular carcinoma after partial hepatectomy, Neoplasia. 2006, 8(9): 696-701. |
|
Researcher
: Chow LWC |
|
Project Title: |
Chemosensitivity study using a breast cancer cell line |
|
Investigator(s): |
Chow LWC |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
05/1996 |
|
Abstract: |
|
To test the effect of combination chemotherapy on cell growth in a breast cancer cell line. |
|
List of Research Outputs |
|
Kwong A., Yiu W.K., Chow L.W.C. and Wong S., Chrysomya Bezziana: an unusual infestation of the breast, The Breast Journal. 2007, 13(3): 297-301. |
|
Kwong A., Yiu W.K., Chow L.W.C. and Wong S.S.Y., Chrysomya bezziana: a rare infestation of the breast., The Breast Journal. 2007, 13: 297-301. |
|
Kwong
A., Yeung D. and Chow L.W.C.,
Monitoring of response of patients with locally advanced breast carcinoma to
neoadjuvant chemohormonotherapy using 18FDG-PET-CT (Post Discussion), |
|
Kwong A., Yeung D. and Chow L.W.C., Update on monitoring of response of patients with locally advanced breast carcinoma to neoadjuvant chemohormonotherapy using 18FDG-PET-CT (Poster Discussion), Breast Cancer Research and Treatment. 2006, 200, Suppl: Abstract 405. |
|
List of Research Outputs |
|
Chan A.O.O., Chu K.M., Huang C.Y., Lam K.F., Leung S.Y., Sun Y., Ko S., Xia H.H.X., Cho C.H., Hui W.M., Lam S.K. and Rashid A., Association between Helicobacter pylori infection and interleukin 1beta polymorphism predispose to CpG island methylation in gastric cancer, GUT. 2007, 56: 595-597. |
|
Chan F.S. and Chu K.M., Predictors for therapeutic
endoscopy in patients with Mallory-Weiss syndrome, Presented at 20th World
Congress of Digestive Surgery, |
|
Chen W.Y.W., Hu X., Liang A.C.T., Au W.Y., So J.C.C., Wong M.L.Y., Shen L., Tao Q., Chu K.M., Kwong Y.L. and Srivastava G., High BCL6 expression predicts better prognosis, independent of BCL6 translocation status, translocation partner, or BCL6 deregulating mutations, in gastric lymphoma, Blood. 2006, 108: 2373-2383. |
|
Chu
K.M., "Common gastrointestinal disorders
in Hong Kong", Lecture for Master of Science in Nursing (Course Code
53070), (Subject SN581 "Primary Care Problems of Adults I"), the |
|
Chu
K.M., "Current status of gastric surgery
in Hong Kong", The 36th Annual Congress of Japanese Society for
Gastro-surgical Pathophysiology, |
|
Chu
K.M., "Gastric and oesophageal
cancers", Certificate Course on Cancer Nursing for Registered and
Enrolled Nurses, The Hong Kong Anti-Cancer Society, |
|
Chu K.M., "Gastric cancer", Preparatory Course for Exit Examination in General Surgery, The College of Surgeons of Hong Kong and Department of Surgery, The University of Hong Kong, Hong Kong, 21 August 2006. 2006. |
|
Chu K.M., "Gastrointestinal diseases", Core Module CMED6600 "Biological Basis of Common Health Problems", Master of Medical Science, The University of Hong Kong, Hong Kong, 8 March 2007. 2007. |
|
Chu
K.M., "Lymph node dissection in
laparoscopic gastrectomy", ELSA 2006, |
|
Chu
K.M., "Minimally invasive surgery for
gastric cancer", 20th World Congress of Digestive Surgery, |
|
Chu K.M., "Minimally invasive treatment of gastric cancer", Conjoint Scientific Congress of The Royal College of Surgeons of Edinburgh and The College of Surgeons of Hong Kong, Hong Kong, 10 - 13 October 2006. 2006. |
|
Chu
K.M., "Surgery for locally advanced
gastric cancer", 1st Asia Pacific Gastric Cancer |
|
Chu
K.M., "Surgical anatomy of D2
gastrectomy", 1st Asia Pacific Gastric Cancer |
|
Chu
K.M., Associate Member , Hereditary
Gastrointestinal Cancer Registry, |
|
Chu
K.M., Chairman for Symposium "Gastric
Cancer - Biology and genetics", 1st Asia Pacific Gastric Cancer |
|
Chu K.M., Chairman for the Free Paper Session "Laparoscopic assisted distal gastrectomy", ELSA 2006, Seoul, Korea, 18 - 21 October 2006. 2006. |
|
Chu
K.M., Chairman for the Session on " Surgical
Oncology", The Hong Kong Surgical Forum, |
|
Chu K.M., Co-Director , Centre for Education and Training, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong. 2007. |
|
Chu
K.M., Council Member , Gerson Lehrman
Group's Council of Healthcare Advisors, Gerson Lehrman Group, |
|
Chu
K.M., Council Member, |
|
Chu
K.M., Council Member, The Federation of
Medical Societies of |
|
Chu K.M., Course Coordinator , Surgical Specialty Clerkship, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital. 2007. |
|
Chu
K.M., Deputy Chairman , Census Meeting,
Department of Surgery, |
|
Chu K.M., Deputy Chairman , Surgical Pathology Meeting, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital. 2007. |
|
Chu
K.M., Deputy Chief of Service, Department
of Surgery, |
|
Chu
K.M., Deputy Departmental Representative, Faculty
Admissions Committee, Faculty of Medicine, The University of |
|
Chu K.M., Deputy Director, Integrated Endoscopy Centre, Hospital Authority Hong Kong West Cluster, Queen Mary Hospital, Hong Kong. 2007. |
|
Chu K.M., Director , Endoscopy Centre, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong. 2007. |
|
Chu K.M., Director , Hong Kong Surgical Forum, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital, Hong Kong. 2007. |
|
Chu K.M., EUS could detect ascites missed by CT scan, Gut. 2006, 55: 1524. |
|
Chu
K.M., Expert Panel in Surgery for HA's
Complaint & Potential Medicolegal cases (July 2001 - present), Hospital
Authority, |
|
Chu
K.M., Expert Reviewer, UICC Fellowships
Programme, International Union Against Cancer (UICC), |
|
Chu K.M., External Advisor / Reviewer , Quality Education Fund Projects, Quality Education Fund (QEF), Hong Kong. 2007. |
|
Chu
K.M., Fellow , Cancer Research Centre,
Faculty of Medicine, The |
|
Chu
K.M., Foundation member , Center for
Alimentary Research and Education (CARE), Faculty of Medicine, The |
|
Chu
K.M., Honorary Consultant (Gastrointestinal
Surgery) , |
|
Chu
K.M., Honorary Consultant , Department of
Surgery, |
|
Chu
K.M., Honorary Consultant in Surgery , |
|
Chu
K.M., Invited Faculty, Hands-on Cadaveric
Dissection, D2 Gastrectomy Workshop, 1st Asia Pacific Gastric Cancer |
|
Chu K.M., Invited Faculty, 7th International Gastric Cancer Congress, Sao Paulo, Brazil, 9 - 12 May 2007. 2007. |
|
Chu K.M., Invited referee (reviewer) April , Clinical Gastroenterology and Hepatology. 2007. |
|
Chu K.M., Invited referee (reviewer) April, Surgical Practice. 2007. |
|
Chu K.M., Invited referee (reviewer) , Asian Journal Surgery. 2006. |
|
Chu K.M., Invited referee (reviewer) , McMaster Online Rating of Evidence (MORE). 2007. |
|
Chu
K.M., Invited referee (reviewer), Abstracts
for the International Surgical Week 2007, |
|
Chu K.M., Invited referee (reviewer), Clinical Gastroenterology and Hepatology. 2007. |
|
Chu K.M., Invited referee (reviewer), Gastroenterology. 2006. |
|
Chu K.M., Invited referee (reviewer), Journal of Gastroenterology and Hepatology. 2007. |
|
Chu K.M., Invited referee (reviewer), Journal of the American College of Surgeons. 2006. |
|
Chu K.M., Invited referee (reviewer), McMaster Online Rating of Evidence (MORE). 2007. |
|
Chu K.M., Invited referee (reviewer), McMaster Online Rating of Evidence (MORE). 2007. |
|
Chu K.M., Invited referee (reviewer), Surgical Practice. 2007. |
|
Chu K.M., Invited referee (reviewer), World Journal of Surgery. 2007. |
|
Chu K.M., Invited referee (reviewer), World Journal of Surgery. 2006. |
|
Chu K.M., Invited referee (reviewer), World Journal of Surgery. 2007. |
|
Chu K.M., Invited referee (reviewer), World Journal of Surgery. 2007. |
|
Chu K.M., Invited referee (reviewer), World Journal of Surgery. 2007. |
|
Chu K.M., Member , Cluster Combined Endoscopy Service Task Group, Hong Kong West Cluster, Hospital Authority. 2007. |
|
Chu
K.M., Member , Examination Sub-Committee,
Licentiate Committee, The Medical Council of |
|
Chu
K.M., Member , Research Committee, The |
|
Chu
K.M., Member , Research Support Unit, The |
|
Chu K.M., Member of Editorial Board, Annals of Cancer Research and Therapy (since 2000). 2007. |
|
Chu K.M., Member of Editorial Board, Asian Journal of Surgery (Associate Editor) (since 2005). 2007. |
|
Chu K.M., Member of Editorial Board, Cancer Therapy (since 2003). 2007. |
|
Chu
K.M., Member of Editorial Board, Cutting
Edge (The |
|
Chu K.M., Member of Editorial Board, Journal of Chinese Clinical Medicine (since 2005) (formerly Chinese Journal of Medicine). 2007. |
|
Chu K.M., Member of the Editorial Board, World Journal of Surgery. 2007. |
|
Chu K.M., Member of the International Scientific Committee, 7th International Gastric Cancer Congress, 9-12 May 2007. 2007. |
|
Chu K.M., Member of the International Scientific Committee, 7th International Gastric Cancer Congress, 9-12 May 2007, Sao Paulo, Brazil. 2007. |
|
Chu K.M., Member, Institutional Review Board of The University of Hong Kong/Hospital Authority Hong Kong West Cluster, Hong Kong. 2007. |
|
Chu K.M., Member, Task Force for Subspecialization, The College of Surgeons of Hong Kong, Hong Kong. 2007. |
|
Chu K.M., QA Research Convenor , Quality Assurance Sub-committee, Undergraduate Education Committee, Faculty of Medicine, The University of Hong Kong, Hong Kong. 2007. |
|
Chu K.M., Secretary General , Asian Surgical Association. 2007. |
|
Lai K.C., Chu K.M., Hui W.M., Wong B.C.Y., Hung W.K., Loo C.K., Hu H.C., Chan O.O., Kwok K.F., Fung T.T., Wong J. and Lam S.K., Esomeprazole with aspirin versus clopidogrel for prevention of recurrent gastrointestinal ulcer complications, Clinical Gastroenterology and Hepatology. 2006, 4: 860-865. |
|
Shin V.Y., Wu K.K., Chu K.M., Koo M.W.L., Wong H.P.S., Lam K.Y., Tai K.K. and Cho C.H., Functional role of b-adrenergic receptor in the mitogenic action of nicotine on gastric cancer cells, Toxicological Sciences. 2007, 96: 21-29. |
|
Tang L.P., Cho C.H., Hui W.M., Huang C., Chu K.M., Xia H.H.X., Lam S.K., Rashid A., Wong B.C.Y. and Chan O.O., An inverse correlation between IL-6 and select gene promoter methylation in patients with gastric cancer, Digestion. 2006, 74: 85-90. |
|
Tse T.F. and Chu K.M., Role of RON activation in chemoresistance in gastric cancer, Presented at 11th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong. 7 December 2006. |
|
Tse T.F. and Chu K.M., Role of RON activation in chemoresistance in gastric cancer, Presented at 20th World Congress of Digestive Surgery, Rome, Italy, 29 November - 1 December 2006. |
|
Tse T.F. and Chu K.M., Role of RON activation in chemoresistance in gastric cancer, Thesis. 2007. |
|
Yeung S.M., Shiu A.T.Y., Martin C.R. and Chu K.M., Translation and validation of the Chinese version of the Gastrointestinal Quality of Life Index (C-GIQLI) in patients with gastric tumor, Journal of Psychosomatic Research. 2006, 61: 469-477. |
|
Researcher
: Chu KW |
|
List of Research Outputs |
|
LU G., Shen J., Fung P.C.W. and Chu K.W., 直結腸癌細胞線粒體超微結構與細胞凋亡的關系., 中國誤診學雜誌, China, 2006, 6(17): 3277-3279. |
|
Lu G., Shen J., You W.L., Fung P.C.W. and Chu K.W., Relationship between Apoptosis and Ultrastructure of Mitochondria of Colorectal Cancer, Chinese Journal of Misdiagnosis. 2006, 6(17): 3277-3279. |
|
Lu G., You W.L., Zhang D.H., Shen J., Fung P.C.W. and Chu K.W., Sampling details when researching the ultrastructure of mitochondria of colorectal cancer, Modern Medicine & Pharmacy. 2006, 16(4): 1-2. |
|
Researcher
: Chu SSM |
|
List of Research Outputs |
|
|
|
Ho K.L., Ma K.K., Au W.H., Chu S.S.M. and Tam P.C., Improving prostate cancer detection with an extended 10-core transrectal ultrasound-guided prostate biopsy protocol in a local Chinese population, 12th Annual Scientific Meeting, Hong Kong Urological Association, Hong Kong, 5 November 2006. |
|
Ho K.L., Chu S.S.M. and Tam P.C., Laparoscopic partial nephrectomy: evaluation of early experience and comparison with open partial nephrectomy, Surgical Practice. 2006, 10 (Suppl.): A29. |
|
Ma K.K., Ho K.L., Chu S.S.M. and Tam P.C., Percutaneous BioGlue injection in treatment of persistent nephroncutaneous fistula after partial nephrectomy, 12th Annual Scientific Meeting, Hong Kong Urological Association, Hong Kong, 5 November 2006. 47. |
|
Tai C.K., Ho K.L., Ma K.K., Au W.H., Chu S.S.M. and Tam P.C., Percent free prostate-specific antigen improves specificity of prostate cancer detection in patients with elevated prostate-specific antigen 4-20ng/ml and non-suspicious digital rectal examination, 12th Annual Scientific Meeting, Hong Kong Urological Association, Hong Kong, 5 November 2006. |
|
Researcher
: Chui WH |
|
List of Research Outputs |
|
Nicholls J.M., Chan M.C.W., Chan W.Y., Wong H.K., Kwong D.L.W., Wong M.P., Chui W.H., Poon L.L.M., Tsao G.S.W., Guan Y. and Peiris J.S.M., Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract, Nature Medicine. 2007, 13(2): 147-149. |
|
Researcher
: Chung MF |
|
List of Research Outputs |
|
Chung M.F., Lam A.K.Y., Luk J.M.C., Law S.Y.K., Chan K.W., Lee P.Y. and Wong J., Clinical significance of e-cadherin and p120 catenin expression and localization in esophageal squamous cell carcinoma, 11th Research Postgraduate Symposium (11th RPS), The University of Hong Kong Li Ka Shing Faculty of Medicine, Hong Kong, 7 December. 2006. |
|
Researcher
: Fan ST |
|
Project Title: |
S.K. Yee Medical Foundation Fellowship in hepatobiliary surgery |
|
Investigator(s): |
Fan ST |
|
Department: |
Surgery |
|
Source(s) of Funding: |
S.K. Yee Medical Foundation - General Award |
|
Start Date: |
11/2000 |
|
Abstract: |
|
To train surgeons from less developed cities in China to acquire the technique and knowledge in dealing with complex hepatobiliary problems so as to benefit patients who cannot afford the cost of receiving treatment in cities like Beijing, Shanghai and Guangzhou. |
|
Project Title: |
Differential proteomic analysis of biomarkers for primary and recurrent hepatocellular carcinoma |
|
Investigator(s): |
Fan ST, Luk JMC |
|
Department: |
Surgery |
|
Source(s) of Funding: |
NSFC/RGC Joint Research Scheme |
|
Start Date: |
12/2003 |
|
Abstract: |
|
To identify potential biomarkers for HCC in liver tissues by proteomic analysis; to detect HCC-specific protein biomarkers in serum by ProteinChip; to predict proteomic analysis of HCC patients with high-risk recurrence after surgery. |
|
Project Title: |
The potential role of cytoplasmic p27kip1 on metastatic tumor pathogenesis of hepatocellular carcinoma |
|
Investigator(s): |
Fan ST, Wang X, Poon RTP |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
01/2005 |
|
Completion Date: |
10/2006 |
|
Abstract: |
|
The main objectives of this project are
to: (1) confim the preliminary observations that p27kip1 was
overexpressed and seemed to be cytoplasmic oncoprotein in the two established
metastatic HCC cell lines; (2) determine how phosphorylation of p27kip1,
such as in which phosphorylation sites and by what regulators, mediate
mislocalization of p27kip |
|
Project Title: |
The significance of focal adhesion kinase and cell adhesion kinas β and their C-terminal non-kinases in liver cancer invsasion and migration |
|
Investigator(s): |
Fan ST, Man K |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
03/2005 |
|
Abstract: |
|
The main objective of this project is to study the significance of focal adhesion kinase(FAK) and cell adhesion kinase β (CAKβ) in liver cancer progression and metastasis. |
|
Project Title: |
Strategic research theme group on Cancer |
|
Investigator(s): |
Fan ST, Ng IOL, Wan JMF, Chiu P, Siu AFM, Chan CLW |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Seed Funding for Strategic Research Theme |
|
Start Date: |
07/2005 |
|
Abstract: |
|
The theme will be on hepatocellular carcinoma (HCC, primary liver cancer) and will focus on factors and strategic leading to long-term survivors. The ultimate aim of cancer research is to detect early tumors and to prolong survival of cancer patients. The studies will focus on biological factors, dietary factors, socio-psychological factors that determine long-term survival and possible alternative medicien that leads to prolonged survival. Tissue and blood stored in the Tissue Bank of the Department of Surgery and Pathology are available for most of the studies. Tumor and blood specimens of forthcoming patients will enhance the pool for validation studies. |
|
Project Title: |
Novel Serological Marker for Liver Cancer |
|
Investigator(s): |
Fan ST, Cheung ST |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
09/2005 |
|
Abstract: |
|
Hepatocellular carcinoma (HCC) is the second most common malignant cancer in Hong Kong. Surgical resection remains the treatment of choice for HCC, but unfortunately at the time of diagnosis, only 10-20% of primary HCCs are resectable. Therefore, serological markers specific for HCC are very important for early disease diagnosis especially for patients who are at risk of developing HCC, including patients who are suffering from liver cirrhosis and chronic hepatitis. In addition, the HCC specific serological markers can also facilitate subsequent monitoring of treatment responsiveness and detection of recurrence after curative treatment. To date, serum alpha-fetoprotein (AFP) is the conventional serum marker of HCC, however, it only has 60% sensitivity and 90% of specificity (at 100 ng/ml cutoff) and the sensitivity decreases to 40% for the detection of small tumors and well-differentiated HCC. A novel serological marker independent of differentiation stages for HCC is urgently required. We have performed a genome-wide expression study, in an effort to identify novel serological markers with high sensitivity and specificity for HCC. From this study, we have shown that a secretory protein - Granulin-Epithelin Precursor (GEP) is significantly up-regulated in 76% HCC tumor tissue (30% of these patients are AFP negative). GEP up-regulation is associated with large HCCs, venous infiltration and early intrahepatic recurrence (P < 0.05). Our study has shown that GEP is a novel growth factor and that it is capable of stimulating HCC cell proliferation, invasion and metastasis suggesting that GEP is a very important factor in HCC (Clinical Cancer Research 2004). |
|
Project Title: |
Focal adhesion kinase and cell adhesion kinase β as the potential therapeutic targets of tumor recurrence and metastasis in hepatocellular carcinoma |
|
Investigator(s): |
Fan ST, Man K, Liu CL |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
07/2006 |
|
Abstract: |
|
To investigate the therapeutic strategies for HCC recurrence and metastasis by targeting at FAK/CAKβ in orthotopic liver cancer nude mice models with different local and distant metastatic potentials by various treatment modalities; to explore the underlying precise molecular mechanisms related to the cell signaling pathways of migration, invasion and angiogenesis. |
|
List of Research Outputs |
|
Au W.Y., Fung A., Liu C.L., Fan S.T., Ma E.S.K., Liang R.H.S. and Kwong Y.L., Serial analysis of JAK2 mutation in a patient who developed essential thrombocythemia after orthotopic liver transplantation (Case Report), American Journal of Hematology. 2006, 81(11): 880-882. |
|
Au W.Y., Au W.Y., Fung T.K., Liu C.L., Fung T.K., Fung T.K., Fan S.T., Ma E.S.K., Liang R.H.S. and Kwong Y.L., Serial analysis of JAK2 mutation in a patient who developed essential thrombocythemia after orthotopic liver transplantation, American Journal of Hematology. 2006, 81(1): 880-882. |
|
Chan A., Poon R.T.P., Mh K.C., Chan S.C., Yuen W.K., Yeung C., Lo C.M. and Fan S.T., Effect of changing paradigm for management of hepatocellular carcinoma on the long-term survival of patients with hepatocellular carcinoma (Abstract), The 1st Biennial Congress of the Asian-Pacific Hepato-Pancreato-Biliary Association, Fukuoka, Japan, 20 - 23 March 2007. |
|
Chan A.C.Y., Lo C.M., Ng K.K.C., Chan S.C. and Fan S.T., Implications for management of Mycobacterium tuberculosis infection in adult-to-adult live donor liver transplantation, Liver International. 2007, 27(1): 81-85. |
|
Chan A.C.Y., Lo C.M., Ng I.O.L. and Fan S.T., Liver transplantation for combined hepatocellular cholangiocarcinoma, Asian Journal of Surgery. 2007, 30(2): 143-146. |
|
Chan S.C., Chik B., Liu C.L., Lo C.M. and Fan S.T., A decade of right liver adult-to-adult live donor liver transplantation: mid-term outcomes (Abstract), The International Liver Transplantation Society 13th Annual International Congress, Rio de Janeiro, Brazil, 20 - 23 June 2007. |
|
Chan S.C., Liu C.L., Lo C.M., Lam B.K.Y., Lee E.W.M. and Fan S.T., Donor quality of life before and after adult-to-adult right liver live donor liver transplantation, Liver Transplantation. 2006, 12(10): 1529-1536. |
|
Chan S.C., Fan S.T., Lo C.M. and Liu C.L., Effect of side and size of graft on surgical outcomes of adult-to-adult live donor liver transplantation, Liver Transplantation. 2007, 13(1): 91-98. |
|
Chan S.C. and Fan S.T., Live liver donor mortality (Letter to the Editor), Liver Transplantation. 2006, 12(9): 1437. |
|
Chan S.C., Fan S.T., Lo C.M., Liu C.L. and Wong J., Toward current standards of donor right hepatectomy for adult-to-adult live donor liver transplantation through the experience of 200 cases, Annals of Surgery. 2007, 245(1): 110-117. |
|
Chan S.C., Fan S.T., Liu C.L., Lo C.M., Lam B.K.Y. and Lee E.W.M., Working up donors for high-urgency and elective adult-to-adult live donor liver transplantation, Liver Transplantation. 2007, 13(4): 509-515. |
|
Chan
V.W.M., Luk J.M.C. and Fan S.T., LI-cadherin
(CDH17)/beta-catenin pathway is involved in tumor proliferation and
metastatic potentials of hepatocellular carcinoma, Hepatology. 2006,
44(4): |
|
Cheng Q., Man K., Ng T.P., Lo C.M., Poon R.T.P. and Fan S.T., The significance of hepatic stellate cell activation on small-for-size fatty liver graft injury (Abstract), The International Liver Transplantation Society 13th Annual International Congress, Rio de Janeiro, Brazil, 20 - 23 June 2007. |
|
Cheung S.T. and Fan S.T., Association of gene polymorphism and expression level in liver cancer (Abstract), The 8th International Meeting on Human Genome Variation and Complex Genome Analysis, Hong Kong, 14 - 16 September 2006. |
|
Cheung S.T., Fan S.T., Lee Y.T., Ng I.O.L. and Lo C.M., Biomarker in relation to post-transplant recurrence in liver cancer patients (Abstract), The 2nd Nanjing-Hong Kong Liver Transplantation Symposium, Nanjing, China, 25 - 27 August 2006. |
|
Cheung S.T., Liu C.L., Chow J.P.H., Lee Y.T., Ip Y.C., Ho J.C.Y. and Fan S.T., Preoperative plasma transcript AA454543 level is an independent prognostic factor for hepatocellular carcinoma after partial hepatectomy, Neoplasia. 2006, 8(9): 696-701. |
|
Cheung S.T., Ho J.C.Y. and Fan S.T., The use of granulin-epithelin precursor (GEP) antibodies for detection and suppression of hepatocellular carcinoma, United States Provisional Patent. No. 60/861,318, 28 November 2006. 2006. |
|
Chik B.H., Liu C.L., Fan S.T., Lo C.M., Poon R.T.P., Lam C.M. and Wong J., Tumor size and operative risks of extended right-sided hepatic resection for hepatocellular carcinoma: implication for preoperative portal vein embolization, Archives of Surgery. 2007, 142(1): 63-69. |
|
Chiu A. and Fan S.T., MARS in the treatment of liver failure: controversies and evidence (Review Article), International Journal of Artificial Organs. 2006, 29(7): 660-667. |
|
Chiu A., Chan L.M. and Fan S.T., Molecular adsorbent recirculating system treatment for patients with liver failure: the Hong Kong experience, Liver International. 2006, 26(6): 695-702. |
|
Chok K.S.H., Ng K.K.C., Poon R.T.P., Lam C.M., Yuen J.H.F., Tso W.K. and Fan S.T., Comparable survival in patients with unresectable hepatocellular carcinoma treated by radiofrequency ablation or transarterial chemoembolization, Archives of Surgery. 2006, 141(12): 1231-1236. |
|
Chok K.S.H., Yuen W.K., Lau H. and Fan S.T., Prospective randomized trial on low-pressure versus standard-pressure pneumoperitoneum in outpatient laparoscopic cholecystectomy, Surgical Laparoscopy, Endoscopy and Percutaneous Techniques. 2006, 16(6): 383-386. |
|
Chow D.H.F., Sinn L.H.Y., Ng K.K.C., Lam C.M., Yuen J.H.F., Fan S.T. and Poon R.T.P., Radiofrequency ablation for hepatocellular carcinoma and metastatic liver tumors: a comprative study, Journal of Surgical Oncology. 2006, 94(7): 565-571. |
|
Chua M.S., Sun H., Cheung S.T., Mason V., Higgins J., Ross D.T., Fan S.T. and So S., Overexpression of NDRG1 is an indicator of poor prognosis in hepatocellular carcinoma, Modern Pathology. 2007, 20(1): 76-83. |
|
Fan S.T., Anterior approach right hepatectomy (Video Lecture), The 30th International Meeting of Surgery, Madrid, Spain, 29 - 31 May 2007. 2007. |
|
Fan S.T., Assessment of early graft function by imaging (Editorial), Liver Transplantation. 2006, 12(9): 1320-1321. |
|
Fan S.T., Associate Editor (June 2002 - June 2007), Liver Transplantation . 2007. |
|
Fan S.T., Chairman - Hepato-pancreatic-biliary surgery, Hong Kong Surgical Forum, 12 - 13 January 2007. 2007. |
|
Fan S.T., Chairman - Session 3: Hepatobiliary and pancreatic surgery, The 1st Joint Hangzhou / Hong Kong Surgical Convention, Hong Kong, 15 January 2007. 2007. |
|
Fan S.T., Chairman - Session 3: Issues in living transplantation – expanding the donor pool I, The Transplantation Society New Key Opinion Leader Meeting, Hong Kong, 18 - 20 January 2007. 2007. |
|
Fan S.T., Chairman - Session 4: Issues in living transplantation – expanding the donor pool II, The Transplantation Society New Key Opinion Leader Meeting, Hong Kong, 18 - 20 January 2007. 2007. |
|
Fan S.T., Chairman, Transplant Centre, Queen Mary Hospital, Hospital Authority, Hong Kong. 2007. |
|
Fan S.T., Consultant Surgeon, Queen Mary Hospital, Hospital Authority, Hong Kong. 2007. |
|
Fan S.T., Consultant of Editorial Board (April 2007 - present), 中華消化外科雜誌, 2007. |
|
Fan S.T., Council Member (January 1998 - present), Hong Kong Chapter, American College of Surgeons. 2007. |
|
Fan S.T., Current status of live donor liver transplantation (Abstract), The International Association for the Study of the Liver / the African Association for the Study of Liver Diseases 2006 Meeting, Cairo, Egypt, 7 - 11 September 2006. |
|
Fan S.T., Current status of live donor liver transplantation (Invited Lecture), The International Association for the Study of the Liver / the African Association for the Study of Liver Diseases 2006 Meeting, Cairo, Egypt, 7 - 11 September 2006. 2006. |
|
Fan S.T., Debate session: LRLTx: Which segment from donor for adult respients? Right liver vs. left liver graft (Invited Lecture), The 1st Biennial Congress of the Asian-Pacific Hepato-Pancreato-Biliary Association, Fukuoka, Japan, 20 - 23 March 2007. 2007. |
|
Fan S.T., Deputy Chief of Service, Department of Surgery, Queen Mary Hospital, Hospital Authority, Hong Kong. 2007. |
|
Fan
S.T., Doctor of Humane Letters, |
|
Fan
S.T., Donor selection and evolving operative
techniques: what has changed? (Abstract), World Transplant Congress, |
|
Fan
S.T., Donor selection and evolving operative
techniques: what has changed? (Invited Lecture), World Transplant
Congress, |
|
Fan
S.T., Donor selection and operative technique
of LDLT – what has changed? (Invited Lecture), The 30th International
Meeting of |
|
Fan
S.T., Expert Clinician, |
|
Fan S.T., Gold Medal, Li Ka Shing Faculty of Medicine. 2006. |
|
Fan
S.T., Honorary Senior Consultant
(Hepatobiliary Surgery), |
|
Fan
S.T., How to decrease morbidity of liver
resection (Invited Lecture), The 30th International Meeting of |
|
Fan
S.T., Intrahepatic cholangiocarcinoma
(Invited Lecture), The 30th International Meeting of |
|
Fan
S.T., Live donor liver transplantation
(Invited Lecture), |
|
Fan
S.T., Live donor liver transplantation
(State-of-the-Art Lecture), |
|
Fan S.T., Live donor liver transplantation in adults, Transplantation. 2006, 82(6): 723-732. |
|
Fan
S.T., Liver transplantation for HCC
(Abstract), The International Liver Transplantation Symposium, |
|
Fan
S.T., Liver transplantation for HCC (Invited
Lecture), The 17th Asian Pacific Association for the Study of the Liver
Conference, |
|
Fan
S.T., Liver transplantation for HCC (Invited
Lecture), The International Liver Transplantation Symposium, |
|
Fan
S.T., Liver transplantation in Hong Kong
(Abstract), Seminar on Organ Donation and Transplantation, |
|
Fan
S.T., Liver transplantation in Hong Kong
(Invited Lecture), |
|
Fan
S.T., Liver transplantation in Hong Kong
(Invited Lecture), Caritas Medical Centre, |
|
Fan
S.T., Liver transplantation in Hong Kong
(Invited Lecture), Department of Medicine, |
|
Fan
S.T., Liver transplantation in Hong Kong
(Invited Lecture), Department of Medicine, |
|
Fan
S.T., Liver transplantation in Hong Kong
(Invited Lecture), |
|
Fan
S.T., Liver transplantation in Hong Kong
(Invited Lecture), Seminar on Organ Donation and Transplantation, |
|
Fan
S.T., Liver transplantation in Hong Kong
(Invited Lecture), |
|
Fan
S.T., Liver transplantation in Hong Kong
(Invited Lecture), |
|
Fan
S.T., Liver transplantation. Who live? Who
die? (Abstract), 07' |
|
Fan S.T., Living donor liver transplantation with reduced monosegments for neonates and small infants (Invited Commentary), Transplantation. 2007, 83(10): 1299-1300. |
|
Fan S.T., Living related liver transplantation in adults (Abstract), The 7th World Congress of the International Hepato-Pancreato-Biliary Association and the 10th Annual Meeting of the Association of Upper GI Surgeons of Great Britain and Ireland, Edinburgh, United Kingdom, 3 - 7 September 2006. |
|
Fan S.T., Living related liver transplantation in adults (Invited Lecture), The 7th World Congress of the International Hepato-Pancreato-Biliary Association and the 10th Annual Meeting of the Association of Upper GI Surgeons of Great Britain and Ireland, Edinburgh, United Kingdom, 3 - 7 September 2006. 2006. |
|
Fan
S.T., Long-term outcomes of radiofrequency
ablation for hepatocellular carcinoma (Symposium Lecture), |
|
Fan S.T., MHV as a guide to exact right or left hepatectomy (Video Lecture), The 30th International Meeting of Surgery, Madrid, Spain, 29 - 31 May 2007. 2007. |
|
Fan
S.T., Lo
C.M. and Liu C.L., Major hepatic
resection for primary and metastatic tumors, In: Fischer JE, Bland KI,
Callery MP, LoGerfo FW, Clagett GP, Seeger JM & Jones DB (eds), Mastery
of Surgery, 5th Edition. |
|
Fan S.T., Member at Large, Executive Committee, International Gastro-Surgical Club. 2007. |
|
Fan S.T., Member of Editorial Board (1991 - present), Journal of Gastroenterology and Hepatology. 2007. |
|
Fan S.T., Member of Editorial Board (1995 - present), Hepato-Gastroenterology. 2007. |
|
Fan S.T., Member of Editorial Board (1998 - present), Archives of Surgery. 2007. |
|
Fan S.T., Member of Editorial Board (2001 - present), 中國肝癌雜誌, 2007. |
|
Fan S.T., Member of Editorial Board (December 2002 - present), 中國普外基礎與臨床雜誌, 2007. |
|
Fan S.T., Member of Editorial Board (December 2003 - present), 移植雜誌, 2007. |
|
Fan S.T., Member of Editorial Board (December 2003 - present), 中華外科治療學雜誌, 2007. |
|
Fan S.T., Member of Editorial Board (January 1993 - present), Hong Kong Practitioner. 2007. |
|
Fan S.T., Member of Editorial Board (January 1999 - present), 中華普通外科雜誌, 2007. |
|
Fan S.T., Member of Editorial Board (January 2000 - present), 中華醫學雜誌, 2007. |
|
Fan S.T., Member of Editorial Board (January 2000 - present), Asian Journal of Surgery. 2007. |
|
Fan
S.T., Member of Editorial Board (January 2000
- present), Journal of Hepatobiliary Pancreatic Surgery ( |
|
Fan S.T., Member of Editorial Board (January 2005 - December 2006), Transplantation. 2007. |
|
Fan S.T., Member of Editorial Board (January 2005 - present), Current Nutrition and Food Science. 2007. |
|
Fan S.T., Member of Editorial Board (July 1999 - present), HPB. 2007. |
|
Fan S.T., Member of Editorial Board (July 2001 - present), 中國實用外科雜誌, 2007. |
|
Fan S.T., Member of Editorial Board (May 1998 - present), 中華肝膽外科雜誌, 2007. |
|
Fan S.T., Member of Editorial Board (May 2002 - April 2007), British Journal of Surgery. 2007. |
|
Fan S.T., Member of Editorial Board (October 1999 - present), Digestive Surgery. 2007. |
|
Fan S.T., Member of Editorial Board (October 2001 - present), Hepatobiliary and Pancreatic Diseases International. 2007. |
|
Fan S.T., Member of Editorial Board (October 2004 - present), World Journal of Gastroenterology. 2007. |
|
Fan S.T., Member of Editorial Board, Journal of Cancer Research and Clinical Oncology. 2007. |
|
Fan
S.T., Member of Subcommittee, Service
Development in Surgery, Hospital Authority, |
|
Fan
S.T., Middle hepatic vein as a landmark for
precise liver resection (Video Presentation), One Day on Pitfalls in Liver
Resection, |
|
Fan S.T., National Delegate (April 1996 - present), International Society of Surgery (ISS) Societe Internationale de Chirurgie (SIC). 2007. |
|
Fan
S.T., Pioneers in transplantation (Invited
Lecture), The Transplantation Society New Key Opinion Leader Meeting, |
|
Fan S.T. and Wong J., Recurrent pyogenic cholangitis, Surgery of the Liver, Biliary Tract and Pancreas. 4th Edition. Philadelphia, Saunders Elsevier, 2006, 971-988. |
|
Fan S.T., Resection and liver transplantation (Abstract), The 2nd Congress of Vascular and Interventional Radiology Foundation, Multi-disciplinary Approach to Clinical Management of Hepatocellular Carcinoma, Hong Kong, 24 September 2006. |
|
Fan S.T., Resection and liver transplantation (Invited Lecture), The 2nd Congress of Vascular and Interventional Radiology Foundation, Multi-disciplinary Approach to Clinical Management of Hepatocellular Carcinoma, Hong Kong, 24 September 2006. 2006. |
|
Fan S.T., Reviewer, American Journal of Gastroenterology. 2007. |
|
Fan S.T., Reviewer, American Journal of Surgery. 2007. |
|
Fan S.T., Reviewer, American Journal of Transplantation. 2007. |
|
Fan S.T., Reviewer, Annals of Surgery. 2007. |
|
Fan S.T., Reviewer, Archives of Surgery. 2007. |
|
Fan S.T., Reviewer, Asian Journal of Surgery. 2007. |
|
Fan S.T., Reviewer, British Journal of Surgery. 2007. |
|
Fan S.T., Reviewer, Digestive Surgery. 2007. |
|
Fan S.T., Reviewer, Gut. 2007. |
|
Fan S.T., Reviewer, HBP Surgery. 2007. |
|
Fan S.T., Reviewer, Hepatology. 2007. |
|
Fan S.T., Reviewer, Intensive Care Medicine. 2007. |
|
Fan S.T., Reviewer, Journal of Cancer Research and Clinical Oncology. 2007. |
|
Fan S.T., Reviewer, Journal of Gastroenterology and Hepatology. 2007. |
|
Fan S.T., Reviewer, Journal of Hepato-Biliary-Pancreatic Surgery. 2007. |
|
Fan S.T., Reviewer, Journal of Surgical Research. 2007. |
|
Fan S.T., Reviewer, Journal of the Pancreas. 2007. |
|
Fan S.T., Reviewer, Liver Transplantation. 2007. |
|
Fan S.T., Reviewer, Nutrition. 2007. |
|
Fan S.T., Reviewer, Surgery. 2007. |
|
Fan S.T., Reviewer, Transplantation. 2007. |
|
Fan S.T., Reviewer, World Journal of Gastroenterology. 2007. |
|
Fan S.T., Reviewer, World Journal of Surgery. 2007. |
|
Fan S.T., Right liver graft and outflow reconstruction (abstract), Clinical Transplantation. 2006, 20(Suppl 16): 18-19. |
|
Fan S.T., Right liver live donor liver transplantation (Video Lecture), The 30th International Meeting of Surgery, Madrid, Spain, 29 - 31 May 2007. 2007. |
|
Fan S.T., Silver Bauhinia Star, The Hong Kong Special Administrative Region. 2006. |
|
Fan S.T., Surgical treatment for liver cancer (Invited Lecture), The 1st Meeting of Central Committee on Liver Diseases, Hospital Authority, Hong Kong, 7 November 2006. 2006. |
|
Fan S.T., Vascular complications of liver resection (Invited Lecture), One Day on Pitfalls in Liver Resection, Amsterdam, The Netherlands, 26 April 2007. 2007. |
|
Fan S.T., Which segment from donor in adult-to-adult live donor liver transplantation (LDLT)? (Abstract), The 1st Biennial Congress of the Asian-Pacific Hepato-Pancreato-Biliary Association, Fukuoka, Japan, 20 - 23 March 2007. |
|
Fan S.T., 討論及修改肝臟移植醫療機構准入審定原則 (Invited Lecture), 衛生部人體器官移植技術臨床應用委員會第二次擴大會議暨全國人體器官移植技術臨床應用管理峰會, 2006年11月12-13日. 2006. |
|
Fan S.T., 活體肝移植的倫理學問題 (Invited Lecture), 中國廣州第三屆羊城肝臟移植高峰論壇暨兩岸三地肝臟移植研討會, 2007年3月1~2日, 2007. |
|
Fan S.T., 活體肝移植供體的評估 (Invited Lecture), 中國長沙第四屆全軍肝膽外科學術會議暨2007肝膽外科論壇, 2007年5月11~13日, 2007. |
|
Fan S.T., 肝臟移植 - 誰生？誰死？(Invited Lecture), 中國北京'07協和肝外科新技術學習班, 2007年4月20~23日, 2007. |
|
Fan
S.T., 活體肝移植相關的倫理學問題
(Invited Lecture), 中國北京第二屆北京國際器官移植論壇暨北京大學器官移植中心成立五周年學術研討會, |
|
Fan
S.T., 香港的肝移植：誰生，誰死？(Invited
Lecture), 香港大學李嘉誠醫學院及香港公共圖書館育醫造才百二載：探索醫學世界公開講座, |
|
Fan S.T., 審定專家工作組 (November 2006 - present), 中華人民共和國衛生部人體器官移植技術臨床應用委員會, 2006. |
|
Hirota M., Takada T., Kawarada Y., Nimura Y., Miura F., Hirata K., Mayumi T., Yoshida M., Strasberg S., Pitt H., Gadacz T.R., de Santibanes E., Gouma D.J., Solomkin J.S., Belghiti J., Neuhaus H., Buchler M.W., Fan S.T., Ker C.G., Padbury R.T., Liau K.H., Hilvano S.C., Belli G., Windsor J.A. and Dervenis C., Diagnostic criteria and severity assessment of acute cholecystitis: Tokyo Guidelines, Journal of Hepato-Biliary-Pancreatic Surgery. 2007, 14(1): 78-82. |
|
Ho
D.W.Y., Yang Z., Lau C.K., Tam K.H., To J.Y.T., Poon R.T.P. and Fan S.T., Therapeutic potential of
cardiotrophin |
|
Ho J.C.Y., Cheung S.T., Poon W.S., Lee Y.T., Ng I.O.L. and Fan S.T., Down-regulation of retinol binding protein 5 is associated with aggressive tumor features in hepatocellular carcinoma, Journal of Cancer Research and Clinical Oncology. 2007. |
|
Ho J.C.Y., Cheung S.T., Patil M.A., Chen X. and Fan S.T., Increased expression of glycosyl-phosphatidylinositol anchor attachment protein 1 (GPAA1) is associated with gene amplification in hepatocellular carcinoma, International Journal of Cancer. 2006, 119(6): 1330-1337. |
|
Ho J.W.Y., Pang R.W.C., Lau C.P.Y., Sun K.W., Yu W.C., Fan S.T. and Poon R.T.P., Significance of circulating endothelial progenitor cells in hepatocellular carcinoma, Hepatology. 2006, 44(4): 836-843. |
|
Hui C.K., Lau E., Monto A., Kim M., Luk J.M.C., Poon R.T.P., Leung N., Lo C.M., Fan S.T., Lau G. and Wright T.L., Natural history of patients with recurrent chronic hepatitis C virus and occult hepatitis B co-infection after liver transplantation, American Journal of Transplantation. 2006, 6(7): 1600-1608. |
|
Hwang I.S.S., Tang F., Leung P.L., Li Y.Y., Fan S.T. and Luk J.M.C., The gene expression of adrenomedullin, calcitonin-receptor-like receptor and receptor activity modifying proteins (RAMPs) in CCl(4)-induced rat liver cirrhosis, Regulatory Peptides. 2006, 135(1-2): 69-77. |
|
Ip Y.C., Cheung S.T. and Fan S.T., Atypical localization of membrane type 1-matrix metalloproteinase in the nucleus is associated with aggressive features of hepatocellular carcinoma, Molecular Carcinogenesis. 2007, 46(3): 225-230. |
|
Lai L., Hui C.K., Poon R.T.P., Shek T.W.H., Lai S.T., Lai J.Y., Lo C.M., Fan S.T., Leung N. and Lau G., The use of transient elastography as a preoperative assessment of hepatic resection (Abstract), The 17th Asian Pacific Association for the Study of the Liver Conference, Kyoto, Japan, 27 - 30 March 2007. Hepatology International. 2007, 1(1): 51. |
|
Lam C.T., Yang Z., Ngai P.P., Fan S.T. and Poon R.T.P., The potential role of brain-derived neurotrophic factor (BDNF) in angiogenesis (Poster Presentation), The 2nd European Conference on Tumor Angiogenesis and Antiangiogenic Therapy (ECTA), Munich, Germany, 14 - 16 September 2006. |
|
Lam C.T., Yang Z., Fan S.T. and Poon R.T.P., The potential role of brain-derived neurotrophic factor (BDNF) in angiogenesis (Poster Presentation), The 98th Annual Meeting of the American Association for Cancer Research, Los Angeles, USA, 14 - 18 April 2007. |
|
Lau
C.K., Yang Z., Ngai P.P., Poon R.T.P. and Fan S.T., HIF |
|
Lau
C.K., Yang Z., Poon R.T.P. and Fan S.T., HIF |
|
Lau C.K., Yang Z., Lam C.T., Tam P.K.H., Poon R.T.P. and Fan S.T., Suppression of hypoxia inducible factor-1a (HIF-1a) by YC-1 is dependent on murine double minute 2 (MDM2), Biochemical and Biophysical Research Communications. 2006, 348(4): 1443-1448. |
|
Lau C.P., Poon R.T.P., Cheung S.T., Yu W.C. and Fan S.T., SPARC and Hevin expression correlate with tumour angiogenesis in hepatocellular carcinoma, Journal of Pathology. 2006, 210(4): 459-468. |
|
Lee K.W., Poon R.T.P., Yuen P.W., Man K., Yang Z., Guan X.Y. and Fan S.T., Rac activation is associated with hepatocellular carcinoma metastasis by up-regulation of vascular endothelial growth factor expression, Clinical Cancer Research. 2006, 12(17): 5082-5089. |
|
Lee K.W., Poon R.T.P., Yuen P.W., Ling M.T., Wang X., Wong Y.C., Guan X.Y., Man K., Tang Z.Y. and Fan S.T., Regulation of angiogenesis by Id-1 through hypoxia-inducible factor-1 mediated vascular endothelial growth factor up-regulation in hepatocellular carcinoma, Clinical Cancer Research. 2006, 12(23): 6910-6919. |
|
Lee K.W., Man K., Poon R.T.P., Lo C.M., Yuen P.W., Ng I.O.L., Ng T.P., Leonard W. and Fan S.T., Signal transducers and activators of transcription 5b activation enhances hepatocellular carcinoma aggressiveness through induction of epithelial-mesenchymal transition, Cancer Research. 2006, 66(20): 9948-9956. |
|
Lee K.W., Poon R.T.P., Yuen P.W., Ling M.T., Kwok W.K., Wang X., Wong Y.C., Guan X.Y., Man K., Chau K.L. and Fan S.T., Twist overexpression correlates with hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition, Clinical Cancer Research. 2006, 12(18): 5369-5376. |
|
Lee P.Y., Cheung N., Lam B.Y.H., Sham P., Lau G., Fan S.T., Luk J.M.C. and Luk J.M.C., Proteomics of mouse liver from embryo to adult: a lesion for HCC (Abstract), The 17th Asian Pacific Association for the Study of the Liver Conference, Kyoto, Japan, 27 - 30 March 2007. Hepatology International. 2007, 1(1): 21. |
|
Lee T.K., Man K., Poon R.T.P., Lo C.M., Yuen P.W., Ng I.O., Ng K.T., Leonard W. and Fan S.T., Cancer Res., Signal transducers and activators of transcription 5b activation enhances hepatocellular carcinoma aggressiveness through induction of epithelial-mesenchymal transition. 2006, 66: 9948-56. |
|
Lee T.K., Poon R.T.P., Yuen P.W., Ling M.T., Kwok W.K., Wang X.H., Wong Y.C., Guan X.Y., Man K., Chau K.L. and Fan S.T., Clin Cancer Res., Twist overexpression correlates with hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition. 2006, 12: 5369-76. |
|
Lee T.K., Poon R.T.P., Yuen P.W., Man K., Yang Z., Guan X.Y. and Fan S.T., Clin Cancer Res, Rac activation is associated with hepatocellular carcinoma metastasis by up-regulation of vascular endothelial growth factor expression. 2006, 12: 5082-9. |
|
Lee T.K., Poon R.T.P., Yuen P.W., Ling M.T., Wang X.H., Wong Y.C., Guan X.Y., Man K., Tang Z.Y. and Fan S.T., Clin Cancer Res, Regulation of angiogenesis by Id-1 through hypoxia-inducible factor-1alpha-mediated vascular endothelial growth factor up-regulation in hepatocellular carcinoma. 2006, 12: 6910-9. |
|
Lee W.Y., Lee P.P.W., Wong W.H.S., Yuen R.M.F., Poon R.T.P., Lai C.L., Fan S.T. and Lau Y.L., Association of Transforming Growth Factor-Beta 1 (TGF-b1) Polymorphisms with Hepatitis B Virus (HBV) Related Fibrosis and Cirrhosis in the Hong Kong Chinese, 11th Research Postgraduate Symposium, Hong Kong, 7 December 2006. |
|
Lin
M.C., Shen Z., Yang Z., Fan S.T. and Kung H.F., Kringle 1
Domain of Human Hepatocyte Growth Factor (HGFK1) Inhibits The Growth and
Metastasis of Hepatocellular Carcinoma in Rats, MGH-HKU-Nature Forum, The |
|
Liu C.L., Fan S.T., Cheung S.T., Lo C.M., Ng I.O.L. and Wong J., Anterior approach versus conventional approach right hepatic resection for large hepatocellular carcinoma: a prospective randomized controlled study, Annals of Surgery. 2006, 244(2): 194-203. |
|
Liu C.L., Fan S.T., Lo C.M., Tso W.K., Lam C.M. and Wong J., Improved operative and survival outcomes of surgical treatment for hilar cholangiocarcinoma, British Journal of Surgery. 2006, 93(12): 1488-1494. |
|
Liu Y., Poon R.T.P., Shao W., Sun X., Chen H., Kok T.W. and Fan S.T., Blockage of epidermal growth factor receptor by quinazoline tyrosine kinase inhibitors suppresses growth of human hepatocellular carcinoma, Cancer Letters. 2007, 248(1): 32-40. |
|
Liu Y., Lei L., Lui E.L.H., Lau C.P.Y., Chen Y., Wo Y.H., Fan S.T. and Poon R.T.P., Tyrosine kinase inhibitor PTK 787/ZK222584 inhibits liver fibrosis (Abstract), The 17th Asian Pacific Association for the Study of the Liver Conference, Kyoto, Japan, 27 - 30 March 2007. Hepatology International. 2007, 1(1): 206. |
|
Lo C.M., Liu C.L., Chan S.C., Lam C.M., Poon R.T.P., Ng I.O.L., Fan S.T. and Wong J., A randomized, controlled trial of postoperative adjuvant interferon therapy after resection of hepatocellular carcinoma, Annals of Surgery. 2007, 245(6): 831-842. |
|
Lo C.M., Lau G., Chan S.C., Fan S.T. and Wong J., Efficacy of a pre-S containing vaccine in patients receiving lamivudine prophylaxis after liver transplantation for chronic hepatitis B, American Journal of Transplantation. 2007, 7(2): 434-439. |
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Lo C.M., Fan S.T., Liu C.L., Chan S.C., Ng I.O.L. and Wong J., Living donor versus deceased donor liver transplantation for early unresectable hepatocellular carcinoma, British Journal of Surgery. 2007, 94(1): 78-86. |
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Luk
J.M.C., Chan V.W.M. and Fan S.T., Cadherin |
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Luk J.M.C., Zhang Q.S., Lee P.Y., Wo Y.H., Leung P.L., Liu L.X., Hu M.Y., Cheung K.F., Hui C.K., Lau G. and Fan S.T., Hepatic stellate cell-targeted delivery of M6P-HSA-glycyrrhetinic acid attenuates hepatic fibrogenesis in a bile duct ligation rat model, Liver International. 2007, 27(4): 548-557. |
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Luk
J.M.C., Yi X. and Fan S.T., Mitochondrial heat shock
protein 75 9MTHSP75) is a predictive marker for early tumor recurrence in
hepatocellular carcinoma (Abstract), Hepatology. 2006, 44(4): |
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Luk J.M.C., Yi X., Lee P.Y., Guan X.Y., Lau G. and Fan S.T., Mortalin-2 is an accurate prognostic biomarker for early recurrence of liver carcinoma (Abstract), The 17th Asian Pacific Association for the Study of the Liver Conference, Kyoto, Japan, 27 - 30 March 2007. Hepatology International. 2007, 1(1): 68. |
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Luo Y., Lo C.M., Cheung C.K.Y., Lau G., Fan S.T. and Wong J., Identification of hepatitis B virus-specific lymphocytes in human liver grafts from HBV-immune donors, Liver Transplantation. 2007, 13(1): 71-79. |
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Man K., Xiao J., Ng T.P., Cheng Q., Sun K.W., Lo C.M., Poon R.T.P. and Fan S.T., Combination therapy for liver tumor growth and metastasis by low dose rapamycin and FTY720 (Paper Presentation), the 14th European Organisation for the Research and Treatment of Cancer, National Cancer Institute, and American Association for Cancer Research (EORTC-NCI-AARC) Symposium on Molecular Targets and Cancer Therapeutics, Prague, Czech Republic, 7 - 10 November 2006. |
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Man K., Ng T.P., Xu A.M., Cheng Q., Sun B., Sun K.W., Lee K.W., Lo C.M., Poon R.T.P. and Fan S.T., Fat-derived hormone adiponectin suppresses liver tumor growth and metastases (Paper Presentation), The 98th Annual Meeting of the American Association for Cancer Research, Los Angeles, USA, 14 - 18 April 2007. |
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Man K., Lo C.M., Ng T.P., Sun S., Sun K.W. and Fan S.T., Significant correlation between intragraft gene expression profiles linking to acute phase injury and angoneness with HCC recurrence after LDLT (Plenary Lecture), The International Liver Transplantation Society 13th Annual International Congress, Rio de Janeiro, Brazil, 20 - 23 June 2007. 2007. |
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Man K., Lo C.M., Xiao J., Ng T.P., Sun K.W., Wang Y. and Fan S.T., The significance of acute phase graft injury on tumor recurrence/metastases in live donor liver transplantation (Abstract), World Transplant Congress 2006, Boston, U.S.A., 22 -27 July 2006. |
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Man K., Lo C.M., Xiao J., Ng T.P., Sun K.W., Wang Y. and Fan S.T., The significance of graft size on tumor recurrence after liver transplantation - activation of cell invasion pathway (Abstract), World Transplant Congress 2006, Boston, U.S.A., 22 - 27 July 2006. |
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Miura F., Takada T., Kawarada Y., Nimura Y., Wada K., Hirota M., Nagino M., Tsuyuguchi T., Mayumi T., Yoshida M., Strasberg S.M., Pitt H.A., Belghitti J., de Santibanes E., Gadacz T.R., Gouma D.J., Fan S.T., Chen M.F., Padbury R.T., Bornman P.C., Kim S.W., Liau K.H., Belli G. and Dervenis C., Flowcharts for the diagnosis and treatment of acute cholangitis and cholecystitis: Tokyo Guidelines, Journal of Hepato-Biliary-Pancreatic Surgery. 2007, 14(1): 27-34. |
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Nagino M., Takada T., Kawarada Y., Nimura Y., Yamashita Y., Tsuyuguchi T., Wada K., Mayumi T., Yoshida M., Miura F., Strasberg S.M., Pitt H.A., Belghiti J., Fan S.T., Liau K.H., Belli G., Chen X.P., Lai E.C., Philippi B.P., Singh H. and Supe A., Methods and timing of biliary drainage for acute cholangitis: Tokyo Guidelines, Journal of Hepato-Biliary-Pancreatic Surgery. 2007, 14(1): 68-77. |
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Ng D.S., Chok K.S., Law W.L., Collins R.J. and Fan S.T., Long-term survival after resection of extrahepatic recurrence of hepatocellular carcinoma at the right colon, International Journal of Colorectal Disease. 2006, 22(11): 1411-1412. |
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Ng K.K.C., Poon R.T.P., Lo C.M., Yuen J.H.F., Tso W.K. and Fan S.T., Analysis of recurrence pattern and its influence on survival outcome after radiofrequency ablation of hepatocellular carcinoma (Grassi Prize Finalist Presentation), The 20th World Congress of the International Society for Digestive Surgery 2006, Rome, Italy, 29 November - 2 December 2006. 2006. |
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Ng K.K.C., Poon R.T.P., Lo C.M., Yuen J.H.F., Tso W.K. and Fan S.T., Analysis of recurrence pattern and survival outcome after radiofrequency ablation of hepatocellular carcinoma: a single institution experience (Abstract), Surgical Practice. 2006, 10: A1. |
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Ng K.K.C., Poon R.T.P., Lo C.M. and Fan S.T., Comparison of laparoscopic and open hepatectomy for small hepatocellular carcinoma (Oral Presentation), The 20th World Congress of the International Society for Digestive Surgery 2006, Rome, Italy, 29 November - 2 December 2006. 2006. |
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Ng K.K.C., Poon R.T.P., Lo C.M. and Fan S.T., Comparison of laparoscopic and open hepatectomy for small hepatocellular carcinoma (Oral Presentation), The Congress of Endoscopic and Laparoscopic Surgeons of Asia 2006, Seoul, Korea, 18 - 21 October 2006. 2006. |
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Ng
T.P., Man K., Sun K.W., Lee K.W., Poon R.T.P., Lo C.M. and Fan S.T., Clinicopathological
significance of homeoprotein Six |
|
Ng
T.P., Man K., Ho J.W.Y., Sun K.W., Lee K.W., Zhao Y., Lo C.M., Poon R.T.P. and Fan S.T., Marked suppression of tumor
growth by FTY |
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Ng T.P., Man K., Cheng Q., Sun B., Lee K.W., Poon R.T.P., Lo C.M. and Fan S.T., Suppression of tumorigenesis and metastasis of hepatocellular of hepatocellular carcinoma by shRNA interference targeting on inhibition of homeoprotein Six1 (Paper Presentation), The 98th Annual Meeting of the American Association for Cancer Research, Los Angeles, USA, 14 - 18 April 2007. |
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Pang R.W.C., Lee K.W., Man K., Poon R.T.P., Fan S.T., Kwong Y.L. and Tse E.W.C., PIN1 expression contributes to hepatic carcinogenesis, Journal of Pathology. 2006, 210(1): 19-25. |
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Pang R.W.C., Lee K.W., Poon R.T.P., Fan S.T., Wong K.B., Kwong Y.L. and Tse E.W.C., Pin1 interacts with a specific serine-proline motif in hepatitis B virus X-protein to enhance hepatocarcinogenesis, Gastroenterology. 2007, 132(3): 1088-1103. |
|
Pang
R.W.C., Poon R.T.P., Fan S.T., Kwong Y.L. and Tse E.W.C., Pin1: a novel regulator of
tumor angiogenesis and invasiveness in hepatocellular carcinoma (Abstract), The
17th Asian Pacific Association for the Study of the Liver Conference, |
|
Poon R.T.P., Ng K.K.C., Tso W.K., Woo R., Pang R.W.C., Tai K.S. and Fan S.T., A phase I/II trial of transarterial chemoembolization for hepatocellular carcinoma using a novel intrarterial drug eluting beads (Abstract), The 5th International Hepatocellular Carcinoma Meeting: Eastern and Western Experiences, Houston, USA, 11 - 13 January 2007. |
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Poon R.T.P., Tam K.H., Yang Z. and Fan S.T., Both p53 dependent and independent pathways contribute to RAD001 mediated enhancement of chemo-sensitivity in hepatocellular carcinoma (Poster Presentation), The 98th Annual Meeting of the American Association for Cancer Research, Los Angeles, USA, 14 - 18 April 2007. |
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Poon
R.T.P., Fan S.T., Lo C.M., Liu C.L. and Wong J., Difference in tumor invasiveness
in cirrhotic patients with hepatocellular carcinoma fulfilling the |
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Poon R.T.P., Fan S.T., Lo C.M., Ng K.K.C., Yuen W.K., Yeung C. and Wong J., External drainage of pancreatic duct with a stent to reduce leakage rate of pancreaticojejunostomy after pancreaticoduodenectomy: a prospective randomized trial (Abstract), Annual Meeting of American Surgical Association, Colorado Springs, USA, 26 - 28 April 2007. |
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Poon R.T.P., Lau C.P.Y., Pang R.W.C., Ng K.K.C., Yuen J.H.F. and Fan S.T., High serum vascular endothelial growth factor levels predict poor prognosis after radiofrequency ablation of hepatocellular carcinoma: importance of tumor biomarker in ablative therapies, Annals of Surgical Oncology. 2007, 14(6): 1835-1845. |
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Poon
R.T.P. and Fan S.T., Liver
resection in cirrhosis of the liver, In: Blumgart L & Belghiti J (eds), Surgery
of the Liver, Biliary Tract and Pancreas. 4th Edition. |
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Sekimoto M., Takada T., Kawarada Y., Nimura Y., Yoshida M., Mayumi T., Miura F., Wada K., Hirota M., Yamashita Y., Strasberg S., Pitt H.A., Belghiti J., de Santibanes E., Gadacz T.R., Hilvano S.C., Kim S.W., Liau K.H., Fan S.T., Belli G. and Sachakul V., Need for criteria for the diagnosis and severity assessment of acute cholangitis and cholecystitis: Tokyo Guidelines, Journal of Hepato-Biliary-Pancreatic Surgery. 2007, 14(1): 11-14. |
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Shen Z., Yang Z., Gao Y., Poon R.T.P., Fan S.T., He M.L., Li T.P., Gan R.B., Kung H.F. and Lin M.C., Kringle 1 Domain of Human Hepatocyte Growth Factor (HGFK1) Inhibits the Growth and Metastasis of Hepatocellular Carcinoma in Rats, 10th Annual Meeting of the American Society of Gene Therapy, May 30-June 3, 2007, at the Washington State Convention and Trade Center in Seattle, WA. 2007. |
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Shen Z., Yang Z., Gao Y., Liu C.C., Ng S.M., Fan S.T., Li T.P., Gan R.B., He M.L., Kung H.F. and Lin M.C., Sustained Expression of Kringle 1 Domain of HGF (HGFK1) Effectively Inhibits Hepatocellular Carcinoma Tumor Growth and Metastasis by a Novel Mechanism, 2006 ISCGT Japan Conference, Chiba, Japan, October 13-15, 2006. |
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Shih K.C., Man K., Ng T.P., Xiao J., Fan S.T. and Lo C.M., Distinct gene signatures linked to acute phase injury and tumor invasiveness in tumor development after liver transplantation using small-for-size grafts (Abstract), The International Liver Transplantation Society 13th Annual International Congress, Rio de Janeiro, Brazil, 20 - 23 June 2007. |
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Shih K.C., Man K., Ng T.P., Xiao J., Fan S.T. and Lo C.M., Rising Star Award - "Distinct gene signatures linked to acute phase injury and tumor invasiveness in tumor development after liver transplantation using small-for-size grafts", The International Liver Transplantation Society 13th Annual International Congress, Rio de Janeiro, Brazil, 20 - 23 June 2007. 2007. |
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Sun
K.W., Man K., Liu C.L., Poon R.T.P. and Fan S.T., The significance of Pyk |
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Tanaka A., Takada T., Kawarada Y., Nimura Y., Yoshida M., Miura F., Hirota M., Wada K., Mayumi T., Gomi H., Solomkin J.S., Strasberg S.M., Pitt H.A., Belghiti J., de Santibanes E., Padbury R., Chen M.F., Belli G., Kerr C.G., Hilvano S.C., Fan S.T. and Liau K.H., Antimicrobial therapy for acute cholangitis: Tokyo Guidelines, Journal of Hepato-Biliary-Pancreatic Surgery. 2007, 14(1): 59-67. |
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Tipoe G.L., Leung T.M., Liong E.C., So H.S.H., Leung K.M., Lau T.Y., Tom W.M., Fung M.L., Fan S.T. and Nanji A.A., Inhibitors of inducible nitric oxide (NO) synthase are more effective than an NO donor in reducing carbon-tetrachloride induced acute liver injury, Histology and Histopathology. 2006, 21(11): 1157-1165. |
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Tsui T.Y., Obed A., Siu Y.T., Yet S.F., Prantl L., Schlitt H.J. and Fan S.T., Carbon monoxide inhalation rescues mice from fulminant hepatitis through improving hepatic energy metabolism, Shock. 2007, 27(2): 165-171. |
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Tsuyuguchi T., Takada T., Kawarada Y., Nimura Y., Wada K., Nagino M., Mayumi T., Yoshida M., Miura F., Tanaka A., Yamashita Y., Hirota M., Hirata K., Yasuda H., Kimura Y., Strasberg S., Pitt H., Buchler M.W., Neuhaus H., Belghiti J., de Santibanes E., Fan S.T., Liau K.H. and Sachakul V., Techniques of biliary drainage for acute cholangitis: Tokyo Guidelines, Journal of Hepato-Biliary-Pancreatic Surgery. 2007, 14(1): 35-45. |
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Wada K., Takada T., Kawarada Y., Nimura Y., Miura F., Yoshida M., Mayumi T., Strasberg S., Pitt H.A., Gadacz T.R., Buchler M.W., Belghiti J., de Santibanes E., Gouma D.J., Neuhaus H., Dervenis C., Fan S.T., Chen M.F., Kerr C.G., Bornman P.C., Hilvano S.C., Kim S.W., Liau K.H. and Kim M.H., Diagnostic criteria and severity assessment of acute cholangitis: Tokyo Guidelines, Journal of Hepato-Biliary-Pancreatic Surgery. 2007, 14(1): 52-58. |
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Wang
C.N., Pon A.K.L., Ho A.H.Y., Chan C.L.W., Fan S.T. and Ho T.H., The Return to Toxicity : The
Regressing Back to Old Habits Amongst Long Term Liver Cancer Survivors in
Hong Kong, The 13th |
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Wang C.N., Pon A.K.L., Ho A.H.Y., Chan C.L.W., Ho T.H. and Fan S.T., The Return to Toxicity: The Regressing Back to Old Habits amongst Long Term Liver Cancer Survivors in Hong Kong, the 13th Hong Kong International Cancer Congress. 2006. |
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Wang X., Redpath J.L., Fan S.T. and Stanbridge E.J., ATR dependent activation of Chk2 and Chk1, Journal of Cellular Physiology. 2006, 208: 613-619. |
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Wang X. and Fan S.T., Chemotherapy increases expression of stem cell marker and cell migration in hepatocellular carcinoma cells (Abstract), 4th International Society for Stem Cell Research Annual Meeting, Toronto, Canada, 1 July 2006. |
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Wang X., Luk J.M.C., Garcia-Barcelo M.M., Miao X., Leung P.L., Ho D.W.Y., Cheung S.T., Lam B.Y.H., Cheung C.K.Y., Wong S.Y., Lau S.S.M., So M.T., Yu W.C., Cai Q., Liu K.S.Y., Hui C.K., Lau G., Poon R.T.P., Wong J. and Fan S.T., Liver intestine-cadherin (CDH17) haplotype is associated with increased risk of hepatocellular carcinoma, Clinical Cancer Research. 2006, 12(17): 5248-5252. |
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Wang X., Miao X., Cai Q., Garcia-Barcelo M.M. and Fan S.T., SMYD3 tandem repeats polymorphism is not associated with the occurrence and metastasis of hepatocellular carcinoma in a Chinese population, Experimental Oncology. 2007, 29(1): 71-73. |
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Yamashita Y., Takada T., Kawarada Y., Nimura Y., Hirota M., Miura F., Mayumi T., Yoshida M., Strasberg S., Pitt H.A., de Santibanes E., Belghiti J., Buchler M.W., Gouma D.J., Fan S.T., Hilvano S.C., Lau J.W., Kim S.W., Belli G., Windsor J.A., Liau K.H. and Sachakul V., Surgical treatment of patients with acute cholecystitis: Tokyo Guidelines, Journal of Hepato-Biliary-Pancreatic Surgery. 2007, 14(1): 91-97. |
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Yang Z., Ho D.W.Y., Ngai P.P., Lau C.K., Zhao Y., Poon R.T.P. and Fan S.T., Antiinflammatory properties of IL-10 rescue small-for-size liver grafts, Liver Transplantation. 2007, 13(4): 558-565. |
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Yang Z., Poon R.T.P., Liu Y., Lau C.K., Ho D.W.Y., Tam K.H., Lam C.T. and Fan S.T., High doses of tyrosine kinase inhibitor PTK787 enhance the efficacy of ischemic hypoxia for the treatment of hepatocellular carcinoma: dual effects on cancer cell and angiogenesis, Molecular Cancer Therapeutics. 2006, 5(9): 2261-2270. |
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Yang Z., Lau C.K., Ngai P.P., Ho D.W.Y., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Induction of long-term liver allograft survival by delayed immunosuppression is dependent on interleukin-10 (Oral Presentation), World Transplant Congress 2006, Boston, U.S.A., 22 - 27 July 2006. |
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Yang Z., Ngai P.P., Lau C.K., Ho D.W.Y., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Induction of long-term liver allograft survival by delayed immunosuppression is dependent on interleukin-10, Liver Transplantation. 2007, 13(4): 571-578. |
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Yang Z., Ho D.W.Y., Lau C.K., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Platelet activation during tumor development, the potential role of BDNF-TrkB autocrine loop, Biochemical and Biophysical Research Communications. 2006, 346(3): 981-985. |
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Yang Z., Ho D.W.Y., Lau C.K., Tam K.H., Lam C.T., Yu W.C., Poon R.T.P. and Fan S.T., Significance of the serum brain-derived neurotrophic factor and platelets in hepatocellular carcinoma, Oncology Reports. 2006, 16(6): 1237-1243. |
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Yoshida M., Takada T., Kawarada Y., Tanaka A., Nimura Y., Gomi H., Hirota M., Miura F., Wada K., Mayumi T., Solomkin J.S., Strasberg S., Pitt H.A., Belghiti J., de Santibanes E., Fan S.T., Chen M.F., Belli G., Hilvano S.C., Kim S.W. and Ker C.G., Antimicrobial therapy for acute cholecystitis: Tokyo Guidelines, Journal of Hepato-Biliary-Pancreatic Surgery. 2007, 14(1): 83-90. |
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Zhang H., Hui C.K., Lee P.Y., Chan W., Yueng Y.H., Leung K.W., Lu L., Leung N., Lo C.M., Fan S.T., Luk J.M.C., Xu A., Lam K.S.L., Kwong Y.L. and Lau G., Serum adiponectin is increased in advancing liver fibrosis and decline with reduction in fibrosis in chronic hepatitis B, The 17th Asian Pacific Association for the Study of the Liver Conference, Kyoto, Japan, 27 - 30 March 2007, Hepatology International. 2007, 242: 7. |
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Zhu L.X., Geng X.P. and Fan S.T., 巨噬細胞及腫瘤壞死因子在肝細胞癌中的表達及意義, 中華肝膽外科雜誌, 2007, 13(1): 41-44. |
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Researcher
: Fan YW |
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List of Research Outputs |
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Xiao H., Au D.K.K., Hui Y., Chow C.K., Fan Y.W. and Wei W.I., Neurofibromatosis type 2 and auditory brainstem implantation., Chinese Medical Journal. 2007, 120(16): 1456-1459. |
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Researcher
: Garcia-Barcelo MM |
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Project Title: |
RET regulatory polymorphisms and susceptibility to Hirschsprung's disease |
|
Investigator(s): |
Garcia-Barcelo MM, Tam PKH, Ganster RW |
|
Department: |
Surgery |
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Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
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Start Date: |
09/2004 |
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Abstract: |
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To study the effect of the RET promoter SNPs on transcription, independently and in conjection with other 5' cis-regulatory elements; to identify the transcription factor functioning at the SNPs site; to investigate whether there is functional and/or physical interactions between PHOX2B and the RET promoter; to test our genetic observations on a larger sample of Chinese HSCR patients; to investigate whether there is association between the transmission of HSCR-susceptibility RET haplotypes and PHOX2B-associated polymorphisms in affected individuals. |
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Project Title: |
Study of the molecular basis of anorectal malformations |
|
Investigator(s): |
Garcia-Barcelo MM, Lui VCH, Tam PKH |
|
Department: |
Surgery |
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Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
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Start Date: |
01/2006 |
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Abstract: |
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To evaluate in patients with isolated ARM and/or VACTERL those genes known to be implicated in ARM according to data provided by i)mutant mice studies and, ii) their role in syndromes that include ARM as part of their spectrum (SHH, GLI3, HOXD12, HOXD13, SALL1, HLXB9, EPHB2); to investigate the gene expression profile during the development of the anorectal region in both, normal and teratogen (ethylenethiourea, ETU)-induced ARMs rat fetuses; to evaluate the genes differentially expressed in the control and in the teratogen ARM-induced embryos as candidates for ARM in humans. |
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Project Title: |
Evaluation of PHOX2B mutations in neuroblastoma patients |
|
Investigator(s): |
Garcia-Barcelo MM, Tam PKH, Miao X |
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Department: |
Surgery |
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Source(s) of Funding: |
Seed Funding Programme for Basic Research |
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Start Date: |
01/2007 |
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Abstract: |
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Objectives: To evaluate the frequency of PHOX2B mutations in Chinese neuroblastoma patients There is a need to clarify the involvement of PHOX2B in both familial and sporadic NB cases, and assess its role in the genetic network underlying NB. Therefore, we propose to conduct a large-scale PHOX2B mutation screening in the Chinese population. We will also perform functional analysis of the mutations found. This study will be conducted on 150 NB patients of Chinese origin and will be the first study ever conducted on Chinese at such relatively large scale. Background and key issues: Neuroblastoma (NB) is the most common solid tumor of childhood. The only known risk factor is the inheritance of mutations in the PHOX2B gene and still obscure genetic predisposition. The hallmark of NB is its heterogeneous clinical behavior, which correlates with somatic genetic changes in the tumor. These changes have proved useful as prognostic markers and represent the result to a cancer initiation process governed by the constitutive DNA endowment of the patient. There are several lines of evidence indicating the complexity of the genetics underlying this disease: i) PHOX2B germ-line mutations are not present in all hereditable NB cases; ii) predisposing loci identified so far differ in families. Neuroblastoma occasionally arises in patients with genetically determined congenital neural crest disorders such as HSCR and CCHS (PHOX2B association with HSCR was described by the PI) (1,2). The recent identification of PHOX2B as the major disease-causing gene in CCHS pointed to PHOX2B as a candidate gene for both familial and syndromic neuroblastoma (3). Trochet et al. (3) reported missense PHOX2B mutations in both a familial case of neuroblastoma and a patient with neuroblastoma and HSCR. In a study of families with neuroblastoma, Mosse et al. (4) identified a frameshift PHOX2B mutation in one family but found no evidence for mutations in this gene in eight other families. These data suggest that PHOX2B mutations may be involved in neuroblastoma tumorigenesis but that germline mutational events in this gene may not be present in all hereditary neuroblastoma cases. Studies in larger numbers of patients will help to determine the frequency of PHOX2B mutations in genetic and sporadic forms of neuroblastoma. Further work is needed to clarify whether 1) PHOX2B mutations in patients with neuroblastoma result in gain or loss of function and 2) PHOX2B is a partner of alternative genetic events that predispose to tumorigenesis. 1.Garcia-Barcelo M, Sham MH, Lui VC, Chen BL, Ott J, Tam PK 2003 Association study of PHOX2B as a candidate gene for Hirschsprung's disease. Gut 52:563–567 2.Rohrer T, Trachsel D, Engelcke G, Hammer J 2002 Congenital central hypoventilation syndrome associated with Hirschsprung's disease and neuroblastoma: case of multiple neurocristopathies. Pediatr Pulmonol 33:71–76 3.Trochet D, Bourdeau F, Janoueix-Lerosey I, Deville A, de Pontual L, Schleiermacher G, Coze C, Philip N, Frebourg T, Munnich A, Lyonnet S, Delattre O, Amiel J 2004 Germline mutations of the paired-like homeobox 2B (PHOX2B) gene in neuroblastoma. Am J Hum Genet 74:761–764 |
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Project Title: |
Functional analysis of RET coding region mutations |
|
Investigator(s): |
Garcia-Barcelo MM, Miao X, Tam PKH |
|
Department: |
Surgery |
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Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
05/2007 |
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Abstract: |
|
Key issues Hirschsprung’s disease (HSCR)
is a congenital disorder in which there is an absence of ganglion cells in
variable portions of the lower digestive tract. HSCR has a complex pattern of
inheritance and manifests with low, sex-dependent penetrance and variability
in the length of the aganglionosis. Its incidence varies among populations,
being more frequent in Asians. HSCR is oligogenic, always requiring RET
(major gene) and other interacting susceptibility alleles. HSCR mostly
presents sporadically although it can be familial (≈5-20%)(1). The RET gene, encoding a tyrosine kinase receptor, is
the major HSCR gene and HSCR-associated germ-line variations/mutations are
found in coding (CDS) and non-coding (NCDS) sequences. The normal development
of the enteric nervous system depends on the integrity or/and stoichiometric
levels of the RET protein(2), which reflect the CDS and/or non-CDS
composition of RET. While HSCR RET-NCDS mutations/variants affect regulatory
sites and may affect RET expression(3-5), CDS mutations/variants are spread
throughout the gene and mainly cause loss-of function of the protein.
Critically, RET gain-of function CDS mutations (exons 10, 11 and 13-16) are
directly implicated in hereditary thyroid cancers (Multiple Endocrine
Neoplasia type 2, and Familiar Medullary Thyroid Carcinoma)(6). Importantly,
some of these have been found in families segregating both HSCR and thyroid
cancer and may have a dual effect in the RET protein. For obvious reasons, an
elementary but essential task of The International Hirschsprung’s Disease
Consortium (of which we are participants) is to establish a
RET-genotype-phenotype correlation(7). This is one of the few cases in which
a gene identified as causal has been fully analyzed from a sufficient number
of individuals of different ethnic groups from whom relevant phenotypic and
genotypic information is available. Despite the overwhelming evidence
implicating RET variants (CDS and NCDS) in HSCR, not many have been
functionally tested and it is of note that the identification of RET-dependent
modifiers as additional susceptibility factors in HSCR may depend on the
classification of the families by mutational type in RET(8). Assessment of
the functional significance of HSCR-associated CDS variants/mutations in RET
is essential for understanding i) phenotypic differences, ii) penetrance and
recurrence risk estimations, iii) the mechanistic of the disease. Objectives
to be achieved To analyse the functional significance of 28 CDS RET
variations/mutations found in Chinese HSCR patients. We are particularly
interested in R114H since it is found in 10% of the Chinese patients and
never been found in the general population, neither Caucasians nor Chinese.
R114H is inherited from unaffected parents and its high frequency in our
population suggests a founder effect. RET-CDS mutations that appear de novo
in sporadic cases are of particular relevance since its pathogenicity may be
determining its penetrance and therefore, their segregation in future
generations. Investigating the mechanisms of pathogenicity of those HSCR RET
mutations located in “cancer” specific domains of the RET protein are
crucial. References 1. Amiel J, Lyonnet S 2001 Hirschsprung disease,
associated syndromes, and genetics: a review. J Med Genet 38:729-739 2.
Pachnis V, Durbec P, Taraviras S, Grigoriou M, Natarajan D 1998 III. Role Of
the RET signal transduction pathway in development of the mammalian enteric
nervous system. Am J Physiol 275:G183-G186 3. Emison ES, McCallion AS, Kashuk
CS, Bush RT, Grice E, Lin S, Portnoy ME, Cutler DJ, Green ED, Chakravarti A |
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List of Research Outputs |
|
Chan Y.K., Tse Y.T., Chan S.Y., Liu W., Garcia-Barcelo M.M., Sham P.C. and Khoo U.S., Estrogen receptors genetic polymorphisms risk association and their functional roles in breast cancer risk: a study on Hong Kong Chinese women, 100th American Association for Cancer Research Annual Meeting, Los Angeles, CA, USA . 2007, Abstract no. 5269. |
|
Fong P.Y., Garcia-Barcelo M.M., Sham P.C., Ng P.K.M., Lau C.F., So M.T., Mak W.W. and Tam P.K.H., Genetic mapping for RET-dependent modifiers in Hirschsprung disease (HSCR), 56th Annual Meeting of the American Society of Human Genetics, New Orleans, U.S.A., 9-13 October 2006. |
|
Garcia-Barcelo M.M., King S.K., Miao X., So M.T., Holden W.T., Moore J.H., Sutcliffe J.R., Hutson J.M. and Tam P.K.H., Application of HapMap data to the evaluation of 8 candidate genes for pediatric slow transit constipation, Journal of Pediatric Surgery. 2007, 42(4): 666-671. |
|
Garcia-Barcelo M.M., Miao X., Lui V.C.H., So M.T., Ngan E.S.W., Leon T.Y., Lau D.K., Liu T.T., Lao X., Guo W., Holden W.T., Moore J. and Tam P.K.H., Correlation between genetic variations in Hox clusters and Hirschsrpung's disease, Annals of Human Genetics. 2007, 71(Pt 4): 526-536. |
|
Garcia-Barcelo
M.M., Developmental genetics of an oligogenic
disorder: Hirschsprung's disease [Invited Lecture], XXXII Annual
Conference of Indian Society of Human Genetics and International Symposium on
Deconstructing uman Diseases: The Genomic Advantage, |
|
Garcia-Barcelo
M.M., Developmental genetics of an oligogenic
disorder: Hirschsprung's disease, XXXII Annual Conference of the Indian
Society of Human Genetics and an International Symposium on
"Deconstructing Human Diseases: The Genomic Advantage", |
|
Garcia-Barcelo M.M., Amiel J., Antinolo G., Borrego S., Burzynski G., Ceccherini I., Emison E., Eng C., Fernandez R., Griseri P., Hofstra R., Kashuk C., Lantien F., Lyonnet S., Miao X., Tam P.K.H., Tullio-Pelet A., West K. and Chakravarti A., Higher prevalence of Hirschsprung disease in China explained by a common RET mutation, 56th Annual Meeting of the American Society of Human Genetics, New Orleans, U.S.A., 9-13 October 2006. |
|
Lui V.C.H., Cheng W.C., Leon Y.Y., Lau K.C., Garcia-Barcelo M.M., Miao X., Wall N. and Tam P.K.H., HOXB5 regulates the expression of RET in ENS: a novel Hirschsprung's gene, The 40th Annual Meeting of the Pacific Association of Paediatric Surgeons together with the Annual Scientific Meeting of the Australasian Association of Paediatric Surgeons, Queenstown, New Zealand, 15-19 April 2007. |
|
Miao X., Garcia-Barcelo M.M., So M.T., Leon Y.Y., Lau K.C., Liu T., Chan E.K.W., Lan L.C.L., Wong K.K.Y., Lui V.C.H. and Tam P.K.H., Role of RET and PHOX2B gene polymorphisms in risk of Hirschsprung's disease in Chinese population, Gut. 2007, 56(5): 736. |
|
Ngan E.S.W., Sit Y.L.F., Lee K.Y., Miao X., Yuan Z., Wang W.L., Nicholls J.M., Wong K.K.Y., Garcia-Barcelo M.M., Lui V.C.H. and Tam P.K.H., Implications of endocrine gland - derived vascular endothelial growth factor/prokineticin-1 signaling in human neuroblastoma progression., Clinical Cancer Research. 2007, 13(3): 868-875. |
|
Ngan
E.S.W., Garcia-Barcelo M.M.,
Lui V.C.H. and Tam P.K.H., Prokineticins in Neural
Crest Cell Growth and Associated Disorders, |
|
Ngan E.S.W., Lui V.C.H., Garcia-Barcelo M.M. and Tam P.K.H., Signaling mechanisms regulating neural crest cells in growth & tumorigenesis [Invited Lecture - Ngan ESW], Stem Cell Workshop: Strategic Research Theme of Development and Reproduction, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, 2-3 November 2006. |
|
Ngan E.S.W., Lui V.C.H., Garcia-Barcelo M.M. and Tam P.K.H., Signaling mechanisms regulating neural crest cells: in growth and tumorigenesis (Invited Lecture), Signalling mechanisms regulating neural crest cells: in growth and tumorigenesis, Stem Cell Workshop , SRT of Development and Reproduction, Hong Kong, 2 - 3 November 2006. 2006. |
|
Tam P.K.H., Garcia-Barcelo M.M., Tullio-Pelet A., Lyonnet S., Lantieri F., Kashuk C., Hofstra R., Griseri P., Fernandez R., Eng C., Emison E., Burzynski G., Ceccherini I., Borrego S., Antinolo G., Amiel J., West K. and Chakravarti A., The International Hirschsprung's Disease Consortium: differential liabiilties of coding and non-coding mutations in complex disease, 53rd Annual International Congress of the British Association of Paediatric Suregons, Stockholm, Sweden, 18-21 July 2006. |
|
Wang X., Luk J.M.C., Garcia-Barcelo M.M., Miao X., Leung P.L., Ho D.W.Y., Cheung S.T., Lam B.Y.H., Cheung C.K.Y., Wong S.Y., Lau S.S.M., So M.T., Yu W.C., Cai Q., Liu K.S.Y., Hui C.K., Lau G., Poon R.T.P., Wong J. and Fan S.T., Liver intestine-cadherin (CDH17) haplotype is associated with increased risk of hepatocellular carcinoma, Clinical Cancer Research. 2006, 12(17): 5248-5252. |
|
Wang X., Miao X., Cai Q., Garcia-Barcelo M.M. and Fan S.T., SMYD3 tandem repeats polymorphism is not associated with the occurrence and metastasis of hepatocellular carcinoma in a Chinese population, Experimental Oncology. 2007, 29(1): 71-73. |
|
Researcher
: He Q |
|
Project Title: |
Molecular dynamics of iron transport |
|
Investigator(s): |
He Q, Sun H |
|
Department: |
Chemistry |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
12/2002 |
|
Completion Date: |
11/2006 |
|
Abstract: |
|
(1) How the chemical properties of the critical metal-binding ligands affect iron binding and release from transferrin in vitro. (2) How a depleted level of transferrin (and iron) in living cells affects the expression of related proteins in the iron-transport pathway. (3) Study the cellular trafficking of transferrin as a possible pathway for delivering drugs and nano-particles besides iron. |
|
Project Title: |
Proteomic approach to study metastasis of esophageal squamous cell carcinoma |
|
Investigator(s): |
He Q |
|
Department: |
Chemistry |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
06/2006 |
|
Abstract: |
|
Background: Esophageal squamous cell
carcinoma (ESCC) is the fourth most common malignancy and still represents a
great health concern in |
|
List of Research Outputs |
|
Researcher
: Ho DWY |
|
List of Research Outputs |
|
Ho D.W.Y., Yang Z., Wong B.Y.H., Kwong D.L.W., Sham J.S.T., Wei W.I. and Yuen P.W., Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry serum protein profiling to identify nasopharyngeal carcinoma, Cancer. 2006, 107(1): 99-107. |
|
Ho
D.W.Y., Yang
Z., Lau C.K., Tam K.H., To J.Y.T., Poon R.T.P. and Fan S.T., Therapeutic potential of
cardiotrophin |
|
Wang X., Luk J.M.C., Garcia-Barcelo M.M., Miao X., Leung P.L., Ho D.W.Y., Cheung S.T., Lam B.Y.H., Cheung C.K.Y., Wong S.Y., Lau S.S.M., So M.T., Yu W.C., Cai Q., Liu K.S.Y., Hui C.K., Lau G., Poon R.T.P., Wong J. and Fan S.T., Liver intestine-cadherin (CDH17) haplotype is associated with increased risk of hepatocellular carcinoma, Clinical Cancer Research. 2006, 12(17): 5248-5252. |
|
Yang Z., Ho D.W.Y., Ngai P.P., Lau C.K., Zhao Y., Poon R.T.P. and Fan S.T., Antiinflammatory properties of IL-10 rescue small-for-size liver grafts, Liver Transplantation. 2007, 13(4): 558-565. |
|
Yang Z., Poon R.T.P., Liu Y., Lau C.K., Ho D.W.Y., Tam K.H., Lam C.T. and Fan S.T., High doses of tyrosine kinase inhibitor PTK787 enhance the efficacy of ischemic hypoxia for the treatment of hepatocellular carcinoma: dual effects on cancer cell and angiogenesis, Molecular Cancer Therapeutics. 2006, 5(9): 2261-2270. |
|
Yang Z., Lau C.K., Ngai P.P., Ho D.W.Y., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Induction of long-term liver allograft survival by delayed immunosuppression is dependent on interleukin-10 (Oral Presentation), World Transplant Congress 2006, Boston, U.S.A., 22 - 27 July 2006. |
|
Yang Z., Ngai P.P., Lau C.K., Ho D.W.Y., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Induction of long-term liver allograft survival by delayed immunosuppression is dependent on interleukin-10, Liver Transplantation. 2007, 13(4): 571-578. |
|
Yang Z., Ho D.W.Y., Lau C.K., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Platelet activation during tumor development, the potential role of BDNF-TrkB autocrine loop, Biochemical and Biophysical Research Communications. 2006, 346(3): 981-985. |
|
Yang Z., Ho D.W.Y., Lau C.K., Tam K.H., Lam C.T., Yu W.C., Poon R.T.P. and Fan S.T., Significance of the serum brain-derived neurotrophic factor and platelets in hepatocellular carcinoma, Oncology Reports. 2006, 16(6): 1237-1243. |
|
Researcher
: Ho JCY |
|
List of Research Outputs |
|
Cheung S.T., Liu C.L., Chow J.P.H., Lee Y.T., Ip Y.C., Ho J.C.Y. and Fan S.T., Preoperative plasma transcript AA454543 level is an independent prognostic factor for hepatocellular carcinoma after partial hepatectomy, Neoplasia. 2006, 8(9): 696-701. |
|
Cheung S.T., Ho J.C.Y. and Fan S.T., The use of granulin-epithelin precursor (GEP) antibodies for detection and suppression of hepatocellular carcinoma, United States Provisional Patent. No. 60/861,318, 28 November 2006. 2006. |
|
Ho J.C.Y., Cheung S.T., Poon W.S., Lee Y.T., Ng I.O.L. and Fan S.T., Down-regulation of retinol binding protein 5 is associated with aggressive tumor features in hepatocellular carcinoma, Journal of Cancer Research and Clinical Oncology. 2007. |
|
Ho J.C.Y., Cheung S.T., Patil M.A., Chen X. and Fan S.T., Increased expression of glycosyl-phosphatidylinositol anchor attachment protein 1 (GPAA1) is associated with gene amplification in hepatocellular carcinoma, International Journal of Cancer. 2006, 119(6): 1330-1337. |
|
Researcher
: Ho JWC |
|
Project Title: |
The Hereditary Gastrointestinal Cancer Registry - a programme for the people of Hong Kong |
|
Investigator(s): |
Ho JWC, |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Terry Fox Fellowship |
|
Start Date: |
06/2000 |
|
Abstract: |
|
To achieve colorectal cancer prevention in high risk families through early detection and timely treatment; to raise awareness of hereditary colorectal cancer through education of the public and the health care profession so as to ensure proper referral of these families to our Registry for the delivery of proper preventive service; to establish support services to improve psychosocial well beings of affected individuals and their at-risk family members; to improve the understanding of hereditary colorectal cancer and its management. |
|
List of Research Outputs |
|
Choi H.K., Law W.L. and Ho J.W.C., Leakage after resection and intraperitoneal anastomosis for colorectal malignancy: analysis of risk factors, Diseases of the Colon and Rectum. 2006, 49(11): 1719-1725. |
|
Law W.L., Choi H.K., Lee Y.M., Ho J.W.C. and Seto C.L., Anastomotic leakage is associated with poor long-term outcome in patients after curative colorectal resection for malignancy, Journal of Gastrointestinal Surgery. 2007, 11: 8-15. |
|
Law W.L., Lee Y.M., Choi H.K., Seto C.L. and Ho J.W.C., Impact of laparoscopic resection for colorectal cancer on operative outcomes and survival, Annals of Surgery. 2007, 245(1): 1-7. |
|
Law W.L., Lee Y.M., Choi H.K., Seto C.L. and Ho J.W.C., Laparoscopic and open anterior resection for upper and mid rectal cancer: an evaluation of outcomes, Diseases of the Colon and Rectum. 2006, 49(8): 1108-1115. |
|
Law W.L., Choi H.K., Lee Y.M. and Ho J.W.C., The impact of postoperative complications on long-term outcomes following curative resection for colorectal cancer, Annals of Surgical Oncology. 2007, 14(9): 2559-2566. |
|
Lo O.S.H., Law W.L., Choi H.K., Lee Y.M., Ho J.W.C. and Seto C.L., Early outcomes of surgery for small bowel obstruction: analysis of risk factors, Langenbeck's Archives of Surgery. 2007, 392(2): 173-178. |
|
Tang Y.H., Lee A.M., Chan C.L.W., Leung P.P.Y., Sham J.S.T., Ho J.W.C. and Cheng J.Y.Y., Disorientation and reconstruction: The meaning searching pathways of patients with colorectal cancer, Journal of Psychosocial Oncology. 2007, 25: 77-102. |
|
Researcher
: Ho JWY |
|
List of Research Outputs |
|
Ho J.W.Y., Pang R.W.C., Lau C.P.Y., Sun K.W., Yu W.C., Fan S.T. and Poon R.T.P., Significance of circulating endothelial progenitor cells in hepatocellular carcinoma, Hepatology. 2006, 44(4): 836-843. |
|
Ng
T.P., Man K., Ho J.W.Y., Sun K.W., Lee K.W., Zhao Y., Lo C.M., Poon R.T.P. and Fan S.T., Marked suppression of tumor
growth by FTY |
|
Researcher
: Ho KL |
|
List of Research Outputs |
|
|
|
Ho K.L., Ma K.K., Au W.H., Chu S.S.M. and Tam P.C., Improving prostate cancer detection with an extended 10-core transrectal ultrasound-guided prostate biopsy protocol in a local Chinese population, 12th Annual Scientific Meeting, Hong Kong Urological Association, Hong Kong, 5 November 2006. |
|
Ho K.L., Chu S.S.M. and Tam P.C., Laparoscopic partial nephrectomy: evaluation of early experience and comparison with open partial nephrectomy, Surgical Practice. 2006, 10 (Suppl.): A29. |
|
Ho K.L., Yip A.W.C., Leung L.S. and Law I.C., Surgical treatment of penile curvature, Hong Kong Medical Journal. 2006, 12(6): 410-414. |
|
Ma K.K., Ho K.L., Chu S.S.M. and Tam P.C., Percutaneous BioGlue injection in treatment of persistent nephroncutaneous fistula after partial nephrectomy, 12th Annual Scientific Meeting, Hong Kong Urological Association, Hong Kong, 5 November 2006. 47. |
|
Tai C.K., Ho K.L., Ma K.K., Au W.H., Chu S.S.M. and Tam P.C., Percent free prostate-specific antigen improves specificity of prostate cancer detection in patients with elevated prostate-specific antigen 4-20ng/ml and non-suspicious digital rectal examination, 12th Annual Scientific Meeting, Hong Kong Urological Association, Hong Kong, 5 November 2006. |
|
Tam
P.C., |
|
Tam P.C., Wong S.C.W., Ho K.L. and Ng E.H.Y., Serum FSH as predictive factor for successful sperm recovery in non-obstructive azoospermic patients (Poster Presentation), Annual Meeting of the American Urological Association, Anaheim, U.S.A., 23 May 2007. |
|
Tam P.C., Wong S.C.W., Ho K.L. and Ng E.H.Y., Serum FSH as predictive factor for successful sperm recovery in non-obstructive azoospermic patients, The Journal of Urology. 2007, 177(4) (Suppl.): 645. |
|
Researcher
: Ho P |
|
List of Research Outputs |
|
Chan Y.C., Ting A.C.W., Ho P., Poon J.T.C., Yiu W.K. and Cheng S.W.K., Supra-aortic hybrid endovascular procedures for complex thoracic aortic disease (Best Paper Session), Conjoint Scientific Congress of the Royal College of Surgeons of England and the College of Surgeons of Hong Kong, Hong Kong, 6-7 May 2007. |
|
Ho P., Cheng S.W.K., Ting A.C.W., Poon J.T.C. and Liu L.H.L., Hybrid endovascular operation for ruptured thoracic aortic aneurysm (Case report), Hong Kong Medical Journal. 2007, 13(1): 78-80. |
|
Ting A.C.W., Cheng S.W.K., Ho P. and Poon J.T.C., Endovascular stent graft repair for infected thoracic aortic pseudoaneurysms - a durable option?, Journal of Vascular Surgery. 2006, 44(4): 701-705. |
|
Researcher
: Ho WK |
|
Project Title: |
Effect of chemotherapy on cochlear function |
|
Investigator(s): |
Ho WK |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
06/1996 |
|
Abstract: |
|
To assess the severity of cochlear damage in patient receiving chemotherapy for cancer. |
|
Project Title: |
Evaluation of a novel electronic device in screening for obstructive sleep syndrome in snore |
|
Investigator(s): |
Ho WK, Chung KF |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
03/2002 |
|
Abstract: |
|
To evaluate the accuracy of the SleepStrip as a tool for obstructive sleep apnea screening insnorers. |
|
Project Title: |
Study of changes in upper airway pressure in patients before and after upper airway surgery for sleep-related breathing disorders: identification of levels of collapse and prediction of surgical response |
|
Investigator(s): |
Ho WK, Wei WI |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2003 |
|
Abstract: |
|
To evaluate the using of multi-level pressure measurements to correlate with the result of surgical treatment. |
|
List of Research Outputs |
|
Ho W.K., Yang Z., Wong B.Y., Kwong D.L.W., Sham J.S.T., Wei W.I. and Yuen P.W., Cancer, Surface-enhanced laser desorption / ionization time-of-flight mass spectrometry serum protein profiling to identify nasopharyngeal carcinoma. 2006, 107: 99-107. |
|
Lam P.K.Y., Chan K.M.K., Ho W.K., Kwong E.Y.L., Yiu E.M.L. and Wei W.I., Cross-cultural Adaptation and Validation of the Chinese Voice Handicap Index-10, Laryngoscope. Hagerstown, MD, Lippincott Williams & Wilkins, Inc., 2006, 116(7): 1192-1198. |
|
Yuen P.W., Cheung S.W.A.N.A., Tang K.C., Ho W.K., Wong B.Y.H., Cheung A.C.S. and Ho A.C.W., The skin prick test result of 977patients suffering from chronic rhinitis in Hong Kong, Hong Kong Medical Journal. 2007, 13: 131-136. |
|
Yuen
P.W., Cheung S., Tang K.C., Ho
W.K., Wong B.Y., Cheung A.C. and Ho A.C., The skin prick test resutls
of 977 patients suffering from chronic rhinitis in Hong Kong, Hong Kong
Medical Journal. |
|
Researcher
: Hui Y |
|
List of Research Outputs |
|
Xiao H., Au D.K.K., Hui Y., Chow C.K., Fan Y.W. and Wei W.I., Neurofibromatosis type 2 and auditory brainstem implantation., Chinese Medical Journal. 2007, 120(16): 1456-1459. |
|
Researcher
: Hung KN |
|
List of Research Outputs |
|
Chua D.T.T., Sham J.S.T., Hung K.N., Leung H.T. and Au G.K.H., Predictive factors of tumor control and survival after radiosurgery of local failures of nasopharyngeal carcinoma., International Journal of Radiation Oncology Biology Physcis. 2006, 66: 1415-1421. |
|
Leung
G.K.K., Ng K.B., Ng J.K.F. and Hung K.N., Best Oral Poster
Presentation. Title: 'Initial experience with the PFA-100® analyzer in
neurosurgical patients taking aspirin.', Annual Scientific Meeting2006,
Hong Kong Neurosurgical Society, |
|
Leung
G.K.K., Ng J.K.F. and Hung K.N., Initial experience with
the PFA-100® analyzer in neurosurgical patients taking aspirin. , Annual
Scientific Meeting 2006. Hong Kong Neurosurgical Society, |
|
Leung S.C.M., Leung G.K.K., Ng K.B. and Hung K.N., Surgery for Brain Metastasis: the Queen Mary Hospital Experience , Annual Scientific Meeting 2006, Hong Kong Neurosurgical Society, Hong Kong, 8 - 9 December 2006. |
|
Researcher
: Hwang ISS |
|
List of Research Outputs |
|
Hwang I.S.S., Tang F., Leung P.L., Li Y.Y., Fan S.T. and Luk J.M.C., The gene expression of adrenomedullin, calcitonin-receptor-like receptor and receptor activity modifying proteins (RAMPs) in CCl(4)-induced rat liver cirrhosis, Regulatory Peptides. 2006, 135(1-2): 69-77. |
|
Researcher
: Ip YC |
|
Project Title: |
Characterization
of claudin |
|
Investigator(s): |
Ip YC, Cheung ST, Fan ST |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
10/2006 |
|
Abstract: |
|
Background:Claudin-10 (CLDN-10) gene
encodes a 20-kD protein with four transmembrane domains. From our previous
genome-wide expression study by cDNA microarray approach on heptocellular
carcinoma (Mol Biol Cell 2002), the CLDN-10 RNA expression level in primary
liver tumour was correlated with disease recurrence. The prognostic
significance of CLDN-10 was consolidated using a second set of primary HCC
(n=53) by quantitative RT-PCR as an independent research method. Results
indicated that the transcript level of CLDN-10 was siginificantly associated
with recurrence (P=0.011). Thus, two sample sets examined by different
techniques both indicated that a higher expression level of CLDN |
|
List of Research Outputs |
|
Cheung S.T., Liu C.L., Chow J.P.H., Lee Y.T., Ip Y.C., Ho J.C.Y. and Fan S.T., Preoperative plasma transcript AA454543 level is an independent prognostic factor for hepatocellular carcinoma after partial hepatectomy, Neoplasia. 2006, 8(9): 696-701. |
|
Ip Y.C., Cheung S.T. and Fan S.T., Atypical localization of membrane type 1-matrix metalloproteinase in the nucleus is associated with aggressive features of hepatocellular carcinoma, Molecular Carcinogenesis. 2007, 46(3): 225-230. |
|
Researcher
: Kam CSK |
|
List of Research Outputs |
|
Chen
Y., Kam C.S.K., Lui V.C.H. and Tam P.K.H., TGF-B blockade aggravates
gut ischemia reperfusion injury via activation of resident macrophages, 53rd
Annual International Congress of the British Association of Paediatric
Surgeons, |
|
Researcher
: Ko S |
|
List of Research Outputs |
|
Chan A.O.O., Chu K.M., Huang C.Y., Lam K.F., Leung S.Y., Sun Y., Ko S., Xia H.H.X., Cho C.H., Hui W.M., Lam S.K. and Rashid A., Association between Helicobacter pylori infection and interleukin 1beta polymorphism predispose to CpG island methylation in gastric cancer, GUT. 2007, 56: 595-597. |
|
Researcher
: Kok TW |
|
List of Research Outputs |
|
Liu Y., Poon R.T.P., Shao W., Sun X., Chen H., Kok T.W. and Fan S.T., Blockage of epidermal growth factor receptor by quinazoline tyrosine kinase inhibitors suppresses growth of human hepatocellular carcinoma, Cancer Letters. 2007, 248(1): 32-40. |
|
Researcher
: Kwok WK |
|
List of Research Outputs |
|
Lee K.W., Poon R.T.P., Yuen P.W., Ling M.T., Kwok W.K., Wang X., Wong Y.C., Guan X.Y., Man K., Chau K.L. and Fan S.T., Twist overexpression correlates with hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition, Clinical Cancer Research. 2006, 12(18): 5369-5376. |
|
Researcher
: Kwong A |
|
List of Research Outputs |
|
Chok S.H., Suen D.T.K. and Kwong A., Factors affecting false-negative rates of sentinel lymph node biopsy in breast cancer (Abstrat 04-06), Surgical Practice. 2006, 10 Suppl. |
|
Chok S.H., Suen D.T.K. and Kwong A., Factors affecting false-negative rates of sentinel lymph node biopsy in breast cancer (Oral), Royal College of Surgeons of Edinburgh, College of Surgeons of Hong Kong Conjoint Scientific Congress, Hong Kong, 10 - 13 October 2006. |
|
Kurian A., Kwong A. and Ford J.M., A Clinic-based study of BRCA1/2 mutation epidemiology in Asdians (Abstract 6053), Breast Cancer Research and Treatment. 2006, 100 Suppl. |
|
Kurian A., Kwong A. and Ford J.M., A Clinic-based study of BRCA1/2 mutation epidemiology in Asians (Poster Presentation), San Antonio Breast Cancer Symposium, U.S.A., 14 - 17 December 2006. |
|
Kwong A., Ad hoc Reviewer (From 2006 - present), Asian Journal of Surgery. 2007. |
|
Kwong A., Breast cancer at a young age and hereditary risk of breast cancer, Hong Kong and Hangzhou Surgical Forum, Hong Kong and Hangzhou, China, 13 - 14 January 2007. 2007. |
|
Kwong A., Breast cancer risk and hereditary risk of brest cancer, American Cancer Society, San Francisco, U.S.A, 7 April 2007. 2007. |
|
Kwong A., Breast cancer: New treatment perspective, Hospital Authority, Hong Kong Anti-Cancer Society, Hong Kong Society of Clinical Oncology organgized talk for patient and general public, Hong Kong, October 2006. 2006. |
|
Kwong A. and Suen D.T.K., Breast conserving surgery in Hong Kong Chinese women (Poster), American Society of Breast Disease, San Francesco, U.S.A, 12 - 14 April 2007. |
|
Kwong A. and Ford J.M., Characterization of the pathogenic mechanism of a novel BRCA2 variant in a Chinese family (Abstract 10541), Journal of Clinical Oncology. 2007, 25, No. 18S, Part I. |
|
Kwong A. and Ford J.M., Characterization of the pathogenic mechanism of a novel BRCA2 variant in a Chinese family (Poster Presentation), 43rd ASCO Meeting, Chicago, U.S.A., 1 - 5 June 2007. |
|
Kwong A., Yiu W.K., Chow L.W.C. and Wong S., Chrysomya Bezziana: an unusual infestation of the breast, The Breast Journal. 2007, 13(3): 297-301. |
|
Kwong A., Yiu W.K., Chow L.W.C. and Wong S.S.Y., Chrysomya bezziana: a rare infestation of the breast., The Breast Journal. 2007, 13: 297-301. |
|
Kwong A., Committee Member, Breast Strategic & CLinical Genetics Gorup, the Hospital Authority, Hong Kong. 2007. |
|
Kwong A. and Ikeda D.M., Comparison of breast density in Asian women and Caucasian women (Poster) (Abstract 3056), Bresat Cancer Research and Treatment. 2006, 100 Suppl. |
|
Kwong A. and Ikeda D.M., Comparison of breast density in Asian women and Caucasian women (Poster) , San Antonio Breast Cancer Symposium, U.S.A., 14 - 17 December 2006. |
|
Kwong A. and Ikeda D.M., Comparison of breast density in Caucasian and Asian women in America with Hong Kong Chinese women (Poster), 8th American Society of Breast Surgeons Meeting, Pheonix, U.S.A., 2 - 6 May 2007. |
|
Kwong A., Director, Hong Kong Herditary and High Risk Breast Cancer Programme, Hong Kong. 2007. |
|
Kwong A., Founder, Hong Kong Hereditary Breast Cancer Family Registry, Hong Kong. 2007. |
|
Kwong A., Hereditary risk of breast and ovarian cancer, HKSH Distinguished Lecture, Hong Kong, January 2007. 2007. |
|
Kwong A., How to reduce risk of breast cancer recurrence, Breast Cancer Patient Health Talk, Novartis, Hong Kong, November 2006. 2006. |
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Kwong A., International Surgical Week, Montreal, Canada, 26 - 30 August 2007, BSI Best Paper Award. 2006. |
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Kwong A. and Ikeda D.M., MRI background enhancement: Its relationship with breast density and breast cancer risk (Poster Presentation), 43rd ASCO Meeting, Chicago, U.S.A., 1- 5 June 2007. |
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Kwong A. and Ikeda D.M., MRI background enhancement: Its relationship with breast density and breast cancer risk (Abstract 1539), Journal of Clinical Oncology. 2007, 25, No. 18S, Part I. |
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Kwong A. and Ikeda D.M., MRI breast density qualification and its relation to background enhancement (Poster), American Society of Breast Disease, San Francesco, U.S.A., 12 - 14 April 2007. |
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Kwong A. and Ikeda D.M., MRI of the breast: quantification of breast density and background enhancement in helathy volunteers (e-poster), ISMRM, Berlin, 19 - 25 May 2007. |
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Kwong A. and Ikeda D.M., Mammographic screening in owmen at increased risk of breast cancer after treatment of Hodgkin' disease (Poster), American Society of Breast Disease, San Francesco, U.S.A., 12 - 14 April 2007. |
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Kwong A., Yeung D. and Chow L.W.C., Monitoring of response of patients with locally advanced breast carcinoma to neoadjuvant chemohormonotherapy using 18FDG-PET-CT (Post Discussion), San Antonio Breast Cancer Symposium, U.S.A., 14 - 17 December 2006. |
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Kwong A., New advances in early diagnosis and prevention of breast cancer, Angus Morre Investments, Hong Kong, 16 June 2007. 2007. |
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Kwong A., Wong L.P., Chan Y.K., Ma E., Khoo U.S. and Ford J.M., Reclassification of BRCA2 Unclassified Variant as Pathogenic in a Chinese Family, International Cancer Congress (13th), Hong Kong, 15 - 17 November 2006. |
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Kwong A., Khoo U.S. and Ford J., Reclassification of a BRCA 2 unclassified variant as pathogenic in a Chinese family (Oral), Hong Kong International Cancer Congress, Hong Kong, 15 - 17 November 2006. |
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Kwong A., Khoo U.S. and Ford J., Reclassification of a BRCA 2 unclassified variant as pathogenic in a Chinese family, Winner of Young Investigator Award, Hong Kong International Cancer Congress, Hong Kong, 15 - 17 November 2006. 2006. |
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Kwong A., Role of traditional Chinese medicine in breast cancer treatment, Annual Scientific Meeting, The College of Surgeons of Hong Kong, Hong Kong, May 2007. 2007. |
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Kwong A., Suen D.T.K. and Cheung T.T., The experience of senitnel lymph node biopsy in Chinese breast cancer patients with prior neo-adjuvant chemotherapy (Poster), St. Gallen Breast Conference, Switzerland, 13 - 18 March 2007. |
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Kwong A., Suen D.T.K. and Cheung T.T., The experience of sentinel lymph node biopsy in Chinese breast cancer patients with prior neo-adjuvant chemotherapy (Abstract S51), The Breast. 2007, 16, Suppl 1. |
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Kwong A., Suen D.T.K. and Cheung T.T., The experience of sentinel lymph node biopsy in Chinease breast cancer patients with prior neo-adjuvant chemotherapy (Abstract), St. Gallen Breast Conference, Switzerland, 14 - 17 March 2007. |
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Kwong A., The role of bisphosphonates in breast cancer management, Hong Kong Society of Clinical Oncology, Hong Kong, 25 May 2007. 2007. |
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Kwong A., Yeung D. and Chow L.W.C., Update on monitoring of response of patients with locally advanced breast carcinoma to neoadjuvant chemohormonotherapy using 18FDG-PET-CT (Poster Discussion), Breast Cancer Research and Treatment. 2006, 200, Suppl: Abstract 405. |
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Kwong A., Who is at risk of breast cancer, HKSH and Ming Pao Newspaer Ltd, Hong Kong, 21 April 2007. 2007. |
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Suen D.T.K. and Kwong A., Breast conserving surgery after neoadjuvant therapy in Chinese breast cancer patients (Poster), NCBC Conference, Las Vegas, U.S.A., 24 - 28 Febraury 2007. |
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Suen D.T.K. and Kwong A., Breast conserving surgery in Hong Kong Chinese women (Oral), Royal College of Surgeons of Edinburgh, College of Surgeons of Hong Kong Conjoint Scientific Congress, Hong Kong, 10 - 13 October 2006. |
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Suen D.T.K. and Kwong A., Breast conserving surgeyr in Hong Kong Chinese women (Abstract 04-04), Surgical Practice. 2006, 10 Suppl. |
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Suen D.T.K. and Kwong A., Factors affecting false-negative rates of sentinel lymph node biopsy in breast cancer (Poster), American Society of Breast Disease, San Francesco, U.S.A., 12 - 14 April 2007. |
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Suen D.T.K. and Kwong A., Response to neoadjuvant chemotherapy and hormonotherapy in Chinese women with breast cancer (Poster), NCBC Conference, Las Vegas, U.S.A., 24 February 2007. |
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Suen D.T.K. and Kwong A., Response to neoadjuvant chemotherapy and hormonotherapy in Chinese women with breast cancer, NCBC Conference, Las Vegas, U.S.A., 24 - 28 February 2007. |
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Suen D.T.K. and Kwong A., The experience of sentinel lymph node biopsy in breast cancer patient with prior neo-adjuvant chemotherapy (Poster), American Society of Breast Disease, U.S.A., 12 - 14 April 2007. |
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Suen D.T.K., Cheung T.T. and Kwong A., The experience of sentinel lymph node biopsy in breast cancer patients with pior neo-adjuvant chemotherapy (Oral), Royal College of Surgeons of Edinburgh, College of Surgeons of Hong Kong Conjoint Scientific Congress, Hong Kong, 10 - 13 October 2006. |
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Suen D.T.K., Cheung T.T. and Kwong A., The experience of sentinel lymph node biopsy in breast cancer patients with prior neo-adjuvant chemotherapy (Abstract 04-07), Surgical Practice. 2006, 10 Suppl. |
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Wong T.Y., Leung R. and Kwong A., The role of Traditional Chinese Medicine in breast cancer patients (Poster), NCBC Conference, Las Vegas, U.S.A., 24 - 28 February 2007. |
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Wong T.Y., Leung R., Leung R. and Kwong A., The role of traditional Chinese medicine in breast cancer, NCBC Conference, Las Vegas, U.S.A., 24 - 28 February 2007. |
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Researcher
: Lam BKY |
|
List of Research Outputs |
|
Chan S.C., Liu C.L., Lo C.M., Lam B.K.Y., Lee E.W.M. and Fan S.T., Donor quality of life before and after adult-to-adult right liver live donor liver transplantation, Liver Transplantation. 2006, 12(10): 1529-1536. |
|
Chan S.C., Fan S.T., Liu C.L., Lo C.M., Lam B.K.Y. and Lee E.W.M., Working up donors for high-urgency and elective adult-to-adult live donor liver transplantation, Liver Transplantation. 2007, 13(4): 509-515. |
|
Researcher
: Lam BYH |
|
List of Research Outputs |
|
Lee P.Y., Cheung N., Lam B.Y.H., Sham P., Lau G., Fan S.T., Luk J.M.C. and Luk J.M.C., Proteomics of mouse liver from embryo to adult: a lesion for HCC (Abstract), The 17th Asian Pacific Association for the Study of the Liver Conference, Kyoto, Japan, 27 - 30 March 2007. Hepatology International. 2007, 1(1): 21. |
|
Wang X., Luk J.M.C., Garcia-Barcelo M.M., Miao X., Leung P.L., Ho D.W.Y., Cheung S.T., Lam B.Y.H., Cheung C.K.Y., Wong S.Y., Lau S.S.M., So M.T., Yu W.C., Cai Q., Liu K.S.Y., Hui C.K., Lau G., Poon R.T.P., Wong J. and Fan S.T., Liver intestine-cadherin (CDH17) haplotype is associated with increased risk of hepatocellular carcinoma, Clinical Cancer Research. 2006, 12(17): 5248-5252. |
|
Researcher
: Lam CM |
|
List of Research Outputs |
|
Chik B.H., Liu C.L., Fan S.T., Lo C.M., Poon R.T.P., Lam C.M. and Wong J., Tumor size and operative risks of extended right-sided hepatic resection for hepatocellular carcinoma: implication for preoperative portal vein embolization, Archives of Surgery. 2007, 142(1): 63-69. |
|
Chok K.S.H., Ng K.K.C., Poon R.T.P., Lam C.M., Yuen J.H.F., Tso W.K. and Fan S.T., Comparable survival in patients with unresectable hepatocellular carcinoma treated by radiofrequency ablation or transarterial chemoembolization, Archives of Surgery. 2006, 141(12): 1231-1236. |
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Chow D.H.F., Sinn L.H.Y., Ng K.K.C., Lam C.M., Yuen J.H.F., Fan S.T. and Poon R.T.P., Radiofrequency ablation for hepatocellular carcinoma and metastatic liver tumors: a comprative study, Journal of Surgical Oncology. 2006, 94(7): 565-571. |
|
Liu C.L., Fan S.T., Lo C.M., Tso W.K., Lam C.M. and Wong J., Improved operative and survival outcomes of surgical treatment for hilar cholangiocarcinoma, British Journal of Surgery. 2006, 93(12): 1488-1494. |
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Lo C.M., Liu C.L., Chan S.C., Lam C.M., Poon R.T.P., Ng I.O.L., Fan S.T. and Wong J., A randomized, controlled trial of postoperative adjuvant interferon therapy after resection of hepatocellular carcinoma, Annals of Surgery. 2007, 245(6): 831-842. |
|
Researcher
: Lam CT |
|
List of Research Outputs |
|
Lam C.T., Yang Z., Ngai P.P., Fan S.T. and Poon R.T.P., The potential role of brain-derived neurotrophic factor (BDNF) in angiogenesis (Poster Presentation), The 2nd European Conference on Tumor Angiogenesis and Antiangiogenic Therapy (ECTA), Munich, Germany, 14 - 16 September 2006. |
|
Lam C.T., Yang Z., Fan S.T. and Poon R.T.P., The potential role of brain-derived neurotrophic factor (BDNF) in angiogenesis (Poster Presentation), The 98th Annual Meeting of the American Association for Cancer Research, Los Angeles, USA, 14 - 18 April 2007. |
|
Lau C.K., Yang Z., Lam C.T., Tam P.K.H., Poon R.T.P. and Fan S.T., Suppression of hypoxia inducible factor-1a (HIF-1a) by YC-1 is dependent on murine double minute 2 (MDM2), Biochemical and Biophysical Research Communications. 2006, 348(4): 1443-1448. |
|
Yang Z., Poon R.T.P., Liu Y., Lau C.K., Ho D.W.Y., Tam K.H., Lam C.T. and Fan S.T., High doses of tyrosine kinase inhibitor PTK787 enhance the efficacy of ischemic hypoxia for the treatment of hepatocellular carcinoma: dual effects on cancer cell and angiogenesis, Molecular Cancer Therapeutics. 2006, 5(9): 2261-2270. |
|
Yang Z., Lau C.K., Ngai P.P., Ho D.W.Y., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Induction of long-term liver allograft survival by delayed immunosuppression is dependent on interleukin-10 (Oral Presentation), World Transplant Congress 2006, Boston, U.S.A., 22 - 27 July 2006. |
|
Yang Z., Ngai P.P., Lau C.K., Ho D.W.Y., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Induction of long-term liver allograft survival by delayed immunosuppression is dependent on interleukin-10, Liver Transplantation. 2007, 13(4): 571-578. |
|
Yang Z., Ho D.W.Y., Lau C.K., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Platelet activation during tumor development, the potential role of BDNF-TrkB autocrine loop, Biochemical and Biophysical Research Communications. 2006, 346(3): 981-985. |
|
Yang Z., Ho D.W.Y., Lau C.K., Tam K.H., Lam C.T., Yu W.C., Poon R.T.P. and Fan S.T., Significance of the serum brain-derived neurotrophic factor and platelets in hepatocellular carcinoma, Oncology Reports. 2006, 16(6): 1237-1243. |
|
Researcher
: Lam CT |
|
List of Research Outputs |
|
Lam C.T., Yang Z., Ngai P.P., Fan S.T. and Poon R.T.P., The potential role of brain-derived neurotrophic factor (BDNF) in angiogenesis (Poster Presentation), The 2nd European Conference on Tumor Angiogenesis and Antiangiogenic Therapy (ECTA), Munich, Germany, 14 - 16 September 2006. |
|
Lam C.T., Yang Z., Fan S.T. and Poon R.T.P., The potential role of brain-derived neurotrophic factor (BDNF) in angiogenesis (Poster Presentation), The 98th Annual Meeting of the American Association for Cancer Research, Los Angeles, USA, 14 - 18 April 2007. |
|
Lau C.K., Yang Z., Lam C.T., Tam P.K.H., Poon R.T.P. and Fan S.T., Suppression of hypoxia inducible factor-1a (HIF-1a) by YC-1 is dependent on murine double minute 2 (MDM2), Biochemical and Biophysical Research Communications. 2006, 348(4): 1443-1448. |
|
Yang Z., Poon R.T.P., Liu Y., Lau C.K., Ho D.W.Y., Tam K.H., Lam C.T. and Fan S.T., High doses of tyrosine kinase inhibitor PTK787 enhance the efficacy of ischemic hypoxia for the treatment of hepatocellular carcinoma: dual effects on cancer cell and angiogenesis, Molecular Cancer Therapeutics. 2006, 5(9): 2261-2270. |
|
Yang Z., Lau C.K., Ngai P.P., Ho D.W.Y., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Induction of long-term liver allograft survival by delayed immunosuppression is dependent on interleukin-10 (Oral Presentation), World Transplant Congress 2006, Boston, U.S.A., 22 - 27 July 2006. |
|
Yang Z., Ngai P.P., Lau C.K., Ho D.W.Y., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Induction of long-term liver allograft survival by delayed immunosuppression is dependent on interleukin-10, Liver Transplantation. 2007, 13(4): 571-578. |
|
Yang Z., Ho D.W.Y., Lau C.K., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Platelet activation during tumor development, the potential role of BDNF-TrkB autocrine loop, Biochemical and Biophysical Research Communications. 2006, 346(3): 981-985. |
|
Yang Z., Ho D.W.Y., Lau C.K., Tam K.H., Lam C.T., Yu W.C., Poon R.T.P. and Fan S.T., Significance of the serum brain-derived neurotrophic factor and platelets in hepatocellular carcinoma, Oncology Reports. 2006, 16(6): 1237-1243. |
|
Researcher
: Lam LK |
|
List of Research Outputs |
|
Cense H.A., Law S.Y.K., Wei W.I., Lam L.K., Ng W.M., Wong K.H., Kwok K.F. and Wong J., Pharyngolaryngoesophagectomy using the thoracoscopic approach, Surgical Endoscopy. 2007, 21(6): 879-884. |
|
Cense H.A., Law S., Wei W.I., Lam L.K., Ng W.M., Wong K.H., Kwok K.F. and Wong J., Surg Endosc, Pharyngolaryngoesophagectomy using the thoracoscopic approach. 2007, 21: 879-884. |
|
Researcher
: Lam S |
|
List of Research Outputs |
|
Lam S., The significance of hepatic stellate cell activation in small-for-size fatty liver graft injury, Thesis, Master of Research (Medicine), The University of Hong Kong. 2007. |
|
Researcher
: Lam SP |
|
List of Research Outputs |
|
Lam S.P., Luk J.M.C. and Lo C.M., Potential use of adult bone marrow stromal cells (BMSCS) treatment in an acute liver failure model induced by D-Galactosamine injection (Abstract), Journal of Hepatology. 2006, 44: S54-S54. |
|
Lam S.P., Lau C.K., Cheung C.K.Y., Man K., Luk J.M.C. and Lo C.M., Potential use of mesenchymal stem cells (MSCs) treatment in D-Galactosamine induced acute liver failure model, American Jouarnal of Transplantation. 2007, 7: 323-323. |
|
Researcher
: Lamb JR |
|
List of Research Outputs |
|
Chen Y., Li X., Tian L., Lui V.C.H., Dallman M.J., Lamb J.R. and Tam P.K.H., Inhibition of sonic hedgehog signaling reduces chronic rejection and prolongs allograft survival in a rat orthotopic small bowel transplantation model, Transplantation. 2007, 83(10): 1351-1357. |
|
Chen Y., Liu Y., Yuan Z., Tian L., Dallman M.J., Thompson P.W., Tam P.K.H. and Lamb J.R., Rosiglitazone suppresses cyclosporin-induced chronic transplant dysfunction and prolongs survival of rat cardiac allografts, Transplantation. 2007, 83(12): 1602-1610. |
|
Researcher
: Lang BHH |
|
List of Research Outputs |
|
Abraham D., Singh N., Lang B.H.H., Chan W.F. and Lo C.Y., Benign nodular goitre presenting as acute airway obstruction, Australia and New Zealand Journal of Surgery. 2007, 77: 364-367. |
|
Chow L.W., Yip A.Y. and Lang B.H.H., Trial of vinorelbine and pegylated liposomal doxorubicin in patients with pretreated metastatic breast cancer , American Journal of Clinical Oncology. 2007, 30(2): 133-138. |
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Lam A.K.Y., Lo C.Y., Leung P., Lang B.H.H., Chan W.F. and Luk J.M.C., The clinicopathological
roles of alterations of tumour suppressor gene p |
|
Lang B.H.H., Co-reviewer, Annals of Surgery. 2007. |
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Lang B.H.H., Co-reviewer, Asian Journal of Surgery. 2007. |
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Lang B.H.H., Co-reviewer, Australian and New Zealand Journal of Surgery. 2007. |
|
Lang B.H.H., Co-reviewer, Clinical Endocrinology (Oxf.). 2007. |
|
Lang B.H.H., Co-reviewer, Endoscopy. 2007. |
|
Lang B.H.H., Co-reviewer, European Journal of Surgical Oncology. 2007. |
|
Lang B.H.H., Co-reviewer, Expert Review of Anticancer Therapy. 2007. |
|
Lang B.H.H., Co-reviewer, Hong Kong Medical Journal. 2007. |
|
Lang B.H.H., Co-reviewer, Southern Medical Journal. 2007. |
|
Lang B.H.H., Co-reviewer, Surgery. 2007. |
|
Lang B.H.H., Co-reviewer, Surgical Practice. 2007. |
|
Lang B.H.H., Co-reviewer, World Journal of Surgery. 2007. |
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Lang B.H.H., Co-reviewer, World Journal of Surgical Oncology. 2007. |
|
Lang B.H.H., Lo C.Y., Chan W.F., Lam K.Y. and Wan K.Y., Prognostic factors in papillary and follicular thyroid carcinoma: their implications for cancer staging, Annals Surgical Oncology. 2007, 14(2): 730-738. |
|
Lang B.H.H., Lo C.Y., Chan W.F., Lam K.Y. and Wan K.Y., Restaging of differentiated thyroid carcinoma by the 6th edition AJCC/UICC TNM staging system: stage migration and predictability, Annals of Surgical Oncology. 2007, 14(5): 1551-1559. |
|
Lang B.H.H., Lo C.Y., Chan W.F., Lam K.Y. and Wan K.Y., Staging for follicular thyroid carcinoma: application to 171 consecutive patients treated in a tertiary referral center, Endocrine-Related Cancer. 2007, 14(1): 29-42. |
|
Lang B.H.H., Lo C.Y., Chan W.F., Lam K.Y. and Wan K.Y., Staging for papillary thyroid carcinoma: a review and comparison, Annals of Surgery. 2007, 245(3): 366-378. |
|
Lang B.H.H. and Lo C.Y., Surgical options in undifferentiated thyroid carcinoma, World Journal of Surgery. 2007, 31: 969-977. |
|
Researcher
: Lang HHB |
|
List of Research Outputs |
|
Lang H.H.B., Cancer staging for differentiated thyroid carcinoma, Thesis, Master of Surgery. 2006. |
|
Lo
C.Y., Lang H.H.B.,
Chan W.F., Kung A.W.C. and Lam K.S.L., A prospective evaluation of
preoperative localization by technetium |
|
Researcher
: Lau CK |
|
List of Research Outputs |
|
Ho
D.W.Y., Yang Z., Lau C.K., Tam K.H., To J.Y.T., Poon R.T.P. and Fan S.T., Therapeutic potential of
cardiotrophin |
|
Lam S.P., Lau C.K., Cheung C.K.Y., Man K., Luk J.M.C. and Lo C.M., Potential use of mesenchymal stem cells (MSCs) treatment in D-Galactosamine induced acute liver failure model, American Jouarnal of Transplantation. 2007, 7: 323-323. |
|
Lau C.K., Yang Z., Ngai P.P., Poon R.T.P. and Fan S.T., HIF |
|
Lau C.K., Yang Z., Poon R.T.P. and Fan S.T., HIF |
|
Lau C.K., Yang Z., Lam C.T., Tam P.K.H., Poon R.T.P. and Fan S.T., Suppression of hypoxia inducible factor-1a (HIF-1a) by YC-1 is dependent on murine double minute 2 (MDM2), Biochemical and Biophysical Research Communications. 2006, 348(4): 1443-1448. |
|
Yang Z., Ho D.W.Y., Ngai P.P., Lau C.K., Zhao Y., Poon R.T.P. and Fan S.T., Antiinflammatory properties of IL-10 rescue small-for-size liver grafts, Liver Transplantation. 2007, 13(4): 558-565. |
|
Yang Z., Poon R.T.P., Liu Y., Lau C.K., Ho D.W.Y., Tam K.H., Lam C.T. and Fan S.T., High doses of tyrosine kinase inhibitor PTK787 enhance the efficacy of ischemic hypoxia for the treatment of hepatocellular carcinoma: dual effects on cancer cell and angiogenesis, Molecular Cancer Therapeutics. 2006, 5(9): 2261-2270. |
|
Yang Z., Lau C.K., Ngai P.P., Ho D.W.Y., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Induction of long-term liver allograft survival by delayed immunosuppression is dependent on interleukin-10 (Oral Presentation), World Transplant Congress 2006, Boston, U.S.A., 22 - 27 July 2006. |
|
Yang Z., Ngai P.P., Lau C.K., Ho D.W.Y., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Induction of long-term liver allograft survival by delayed immunosuppression is dependent on interleukin-10, Liver Transplantation. 2007, 13(4): 571-578. |
|
Yang Z., Ho D.W.Y., Lau C.K., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Platelet activation during tumor development, the potential role of BDNF-TrkB autocrine loop, Biochemical and Biophysical Research Communications. 2006, 346(3): 981-985. |
|
Yang Z., Ho D.W.Y., Lau C.K., Tam K.H., Lam C.T., Yu W.C., Poon R.T.P. and Fan S.T., Significance of the serum brain-derived neurotrophic factor and platelets in hepatocellular carcinoma, Oncology Reports. 2006, 16(6): 1237-1243. |
|
Researcher
: Lau CK |
|
List of Research Outputs |
|
Ho
D.W.Y., Yang Z., Lau C.K., Tam K.H., To J.Y.T., Poon R.T.P. and Fan S.T., Therapeutic potential of
cardiotrophin |
|
Lam S.P., Lau C.K., Cheung C.K.Y., Man K., Luk J.M.C. and Lo C.M., Potential use of mesenchymal stem cells (MSCs) treatment in D-Galactosamine induced acute liver failure model, American Jouarnal of Transplantation. 2007, 7: 323-323. |
|
Lau C.K., Yang Z., Ngai P.P., Poon R.T.P. and Fan S.T., HIF |
|
Lau C.K., Yang Z., Poon R.T.P. and Fan S.T., HIF |
|
Lau C.K., Yang Z., Lam C.T., Tam P.K.H., Poon R.T.P. and Fan S.T., Suppression of hypoxia inducible factor-1a (HIF-1a) by YC-1 is dependent on murine double minute 2 (MDM2), Biochemical and Biophysical Research Communications. 2006, 348(4): 1443-1448. |
|
Yang Z., Ho D.W.Y., Ngai P.P., Lau C.K., Zhao Y., Poon R.T.P. and Fan S.T., Antiinflammatory properties of IL-10 rescue small-for-size liver grafts, Liver Transplantation. 2007, 13(4): 558-565. |
|
Yang Z., Poon R.T.P., Liu Y., Lau C.K., Ho D.W.Y., Tam K.H., Lam C.T. and Fan S.T., High doses of tyrosine kinase inhibitor PTK787 enhance the efficacy of ischemic hypoxia for the treatment of hepatocellular carcinoma: dual effects on cancer cell and angiogenesis, Molecular Cancer Therapeutics. 2006, 5(9): 2261-2270. |
|
Yang Z., Lau C.K., Ngai P.P., Ho D.W.Y., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Induction of long-term liver allograft survival by delayed immunosuppression is dependent on interleukin-10 (Oral Presentation), World Transplant Congress 2006, Boston, U.S.A., 22 - 27 July 2006. |
|
Yang Z., Ngai P.P., Lau C.K., Ho D.W.Y., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Induction of long-term liver allograft survival by delayed immunosuppression is dependent on interleukin-10, Liver Transplantation. 2007, 13(4): 571-578. |
|
Yang Z., Ho D.W.Y., Lau C.K., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Platelet activation during tumor development, the potential role of BDNF-TrkB autocrine loop, Biochemical and Biophysical Research Communications. 2006, 346(3): 981-985. |
|
Yang Z., Ho D.W.Y., Lau C.K., Tam K.H., Lam C.T., Yu W.C., Poon R.T.P. and Fan S.T., Significance of the serum brain-derived neurotrophic factor and platelets in hepatocellular carcinoma, Oncology Reports. 2006, 16(6): 1237-1243. |
|
Researcher
: Lau CPY |
|
List of Research Outputs |
|
Ho J.W.Y., Pang R.W.C., Lau C.P.Y., Sun K.W., Yu W.C., Fan S.T. and Poon R.T.P., Significance of circulating endothelial progenitor cells in hepatocellular carcinoma, Hepatology. 2006, 44(4): 836-843. |
|
Liu Y., Lei L., Lui E.L.H., Lau C.P.Y., Chen Y., Wo Y.H., Fan S.T. and Poon R.T.P., Tyrosine kinase inhibitor PTK 787/ZK222584 inhibits liver fibrosis (Abstract), The 17th Asian Pacific Association for the Study of the Liver Conference, Kyoto, Japan, 27 - 30 March 2007. Hepatology International. 2007, 1(1): 206. |
|
Poon R.T.P., Lau C.P.Y., Pang R.W.C., Ng K.K.C., Yuen J.H.F. and Fan S.T., High serum vascular endothelial growth factor levels predict poor prognosis after radiofrequency ablation of hepatocellular carcinoma: importance of tumor biomarker in ablative therapies, Annals of Surgical Oncology. 2007, 14(6): 1835-1845. |
|
Researcher
: Lau H |
|
List of Research Outputs |
|
Chok K.S.H., Yuen W.K., Lau H. and Fan S.T., Prospective randomized trial on low-pressure versus standard-pressure pneumoperitoneum in outpatient laparoscopic cholecystectomy, Surgical Laparoscopy, Endoscopy and Percutaneous Techniques. 2006, 16(6): 383-386. |
|
Lau H., Day case endoscopic versus open hernioplasty of inguinal hernia, 11th Joint Shanghai/Hong Kong Surgical Convention, Rui Jin Hospital, Shanghai Jiao Tong University, Shanghai, China, 10 July 2006. |
|
Lau H., Endoscopic totally extraperitoneal inguinal hernioplasty (Invited live demonstration), Advanced Laparoscopic Surgery Course for HST, Minimally Access Surgery Training Centre, Pamela Youde Nethersole Eastern Hospital and Prince of Wales Hospital, Hong Kong, 27 - 28 July 2006. 2006. |
|
Lau H., Endoscopic totally extraperitoneal inguinal hernioplasty, Advanced Laparoscopic Surgery Course for HST, Mnimal Access Surgery Training Centre, Pamela Youde Nethersole Eastern Hospital and Prince of Wales Hospital, Hong Kong, 27-28 July 2006. |
|
Lau H., Examiner, Mock Examination for MRCS Final Assessment & FRCS Exit Examination, Hong Kong, 2 September 2006. 2006. |
|
Lau H., Examiner, Preparatory Course for the Exit Examination, Queen Mary Hospital, 21 August 2006. 2006. |
|
Lau H., Inguinal hernia in females, Metro Daily, 1 September 2006. 2006, 24. |
|
Lau H., Member, Conjoint Scientific Congress of The Royal College of Surgeons of Edinburgh and The College of Surgeons of Hong Kong 2006, Hong Kong, 10-13 October 2006. 2006. |
|
Lau H., Fang C., Yuen W.K. and Patil N.G., Risk factors for inguinal hernia in adult males: a case-control study, Surgery. 2007, 141(2): 262-266. |
|
Lau
H., 腹腔鏡全腹膜外补片植入術和腹腔鏡前腹壁疝根治術 (Invited), 第四屆全國疝和腹壁外科學術研討會暨哈爾濱,華醫學會外科學會,疝與腹壁外科學組, 中國, |
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Wan S.H., Lau H., Patil N.G., Lo W.K. and Lui S.K., Peritoneal computed tomograph: a diagnostic tool for genital oedema in patients on peritoneal analysis, Hong Kong Medical Journal. 2007, 13(1): 82-83. |
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Researcher
: Lau KC |
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List of Research Outputs |
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Lau K.C., Evaluation of the Thyroid Transcription Factor 1 (TTF1) and Homeobox B5 (HOXB 5) as Hirschsprung Disease (HSCR) susceptibility loci , Thesis, Master of Philosophy. 2006. |
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Lui V.C.H., Cheng W.C., Leon Y.Y., Lau K.C., Garcia-Barcelo M.M., Miao X., Wall N. and Tam P.K.H., HOXB5 regulates the expression of RET in ENS: a novel Hirschsprung's gene, The 40th Annual Meeting of the Pacific Association of Paediatric Surgeons together with the Annual Scientific Meeting of the Australasian Association of Paediatric Surgeons, Queenstown, New Zealand, 15-19 April 2007. |
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Miao X., Garcia-Barcelo M.M., So M.T., Leon Y.Y., Lau K.C., Liu T., Chan E.K.W., Lan L.C.L., Wong K.K.Y., Lui V.C.H. and Tam P.K.H., Role of RET and PHOX2B gene polymorphisms in risk of Hirschsprung's disease in Chinese population, Gut. 2007, 56(5): 736. |
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Researcher
: Lau SF |
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List of Research Outputs |
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Cheuk L.Y., Lau S.F. and Cheng S.W.K., Carotid intima-media thickness in patients with abdominal aortic aneurysms, European Journal of Vascular and Endovascular Surgery. 2007, 33(2): 149-153. |
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Researcher
: Lau SSM |
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List of Research Outputs |
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Wang X., Luk J.M.C., Garcia-Barcelo M.M., Miao X., Leung P.L., Ho D.W.Y., Cheung S.T., Lam B.Y.H., Cheung C.K.Y., Wong S.Y., Lau S.S.M., So M.T., Yu W.C., Cai Q., Liu K.S.Y., Hui C.K., Lau G., Poon R.T.P., Wong J. and Fan S.T., Liver intestine-cadherin (CDH17) haplotype is associated with increased risk of hepatocellular carcinoma, Clinical Cancer Research. 2006, 12(17): 5248-5252. |
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Researcher
: Law IC |
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List of Research Outputs |
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Ho K.L., Yip A.W.C., Leung L.S. and Law I.C., Surgical treatment of penile curvature, Hong Kong Medical Journal. 2006, 12(6): 410-414. |
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Researcher
: Law SYK |
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Project Title: |
The use of combined Lutetium Oxyorthosilicate (LSO) Positron Emission Scan and CT scan in staging of esophageal cancer. |
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Investigator(s): |
Law SYK, Sham JST, Ooi CGC, Kwong DLW, Wong J |
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Department: |
Surgery |
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Source(s) of Funding: |
Other Funding Scheme |
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Start Date: |
03/2002 |
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Abstract: |
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To analysis the use of combined Lutetium Oxyorthosilicate (LSO) Positron Emission Scan and CT scan in staging of esophageal cancer. |
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Project Title: |
Potential Roles of RON and Its Ligand Macrophage Stimulating Protein (MSP) as Prognostic Markers in Esophageal Squamous Cell Carcinoma (ESCC) |
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Investigator(s): |
Law SYK, Luk JMC |
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Department: |
Surgery |
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Source(s) of Funding: |
Seed Funding Programme for Basic Research |
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Start Date: |
03/2006 |
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Abstract: |
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Esophageal cancer is the sixth most
frequent cause of cancer death in the world. Esophageal squamous cell
carcinoma (ESCC) is the commonest histological cell type in Asia and in Hong
Kong. Advances in operative techniques and peri-operative care have made
esophagectomy a safe procedure in specialized centers. In spite of this and
recent advances in multimodality treatments including chemotherapy and
radiotherapy, the prognosis of patients with esophageal cancer remains poor
because of late diagnosis, the propensity of early spread of disease, and its
occurrence in a group of elderly patients with co-morbid illnesses. The
identification of a sensitive and specific disease marker is important for
prognostication and to guide appropriate treatment. RON (Récepteur d’Origine
Nantais) is a 185kDa tyrosine kinase receptor in the MET family. It is a
transmembrane protein consists of a 150kDa β-subunit and a 40kDa α-subunit
which are disulfide-linked. The receptor is normally expressed on epithelial
cells, macrophages, bone marrow stem cells, and osteoclasts. It mediates a
broad range of biological activities including cell proliferation, cellular
adhesion, invasion, motility, metastasis, epithelial to mesenchymal
transition, and inhibitions of apoptosis as well as anoikis. Many of these
processes are involved in carcinogenesis. Binding of RON to its ligand
macrophage stimulating protein (MSP) leads to tyrosine phosphorylation of the
receptor and subsequent signal transduction, such as the focal adhesion
kinase (FAK) and PI3-K/Akt or Ras signaling pathways (1). MSP belongs to the
plasminogen-related kringle protein family. Inactive 78kDa single-chain
pro-MSP is synthesized in hepatocytes and secreted into the circulating
blood. Cleavage and activation of pro-MSP in the extravascular compartments
result in the formation of disulfide-linked 53kDa α chain and 25kDa β chain,
which contains the kringle domains and serine protease domain respectively.
MSP was recently named hepatocyte growth factor (HGF)-like protein because of
its up to 45% homology to HGF (2). We have shown that serum level of HGF correlates
with tumor stage and metastasis in ESCC. It may participate in tumor
angiogenesis via autocrine or paracrine mechanisms. Upon binding to c-Met,
HGF might play a role in promoting ESCC cell invasion, migration and tumour
metastasis. Normal epithelial cells are not affected (3). We hypothesize that
MSP could be detected in serum and it may have a prognostic value in ESCC.
Currently, commercially available MSP antibody is not well established for
the specific detection of the MSP antigen. None has been shown to be
efficient and reliable. The first objective of the present proposal is to
establish specific monoclonal antibodies against MSP for developing
immunoassay(s) for measurement of MSP serum levels in normal subjects and
ESCC patients in order to evaluate the potential usefulness of MSP as a
prognostic marker. RON, together with c-Met, which is a proto-oncogene, are
the only MET family members that exist in humans (4). c-Met is a receptor for
hepatocyte growth factor (HGF), and is found in high levels in esophageal
tumour cells (3). Co-expression of RON and c-Met has been observed in
node-negative breast cancers and ovarian cancers (5,6). Over-expression of
RON alone was also found to associate with tumor development and metastasis.
RON over-expression and constitutive activation were observed in breast
cancer, lung cancer, ovarian carcinomas, colorectal adenocarcinomas, and
hepatocellular carcinomas (6-11). The increased expression of RON on cell
surface favors homodimerization and receptor activation which is sufficient
to induce subsequent signal transductions. Persistent RON expression and
activation leading to the loss of epithelial phenotypes also correlates with
cancer cells’ abilities to invade and migrate (12). In addition to the
wild-type RON, splicing variants (RONΔ165, RONΔ160, RONΔ155) were detected in
various malignancies including colon and gastric cancers. All the variants
have the ability to induce cell scatter in a ligand-independent way (9). We
hypothesize that dysregulated RON or its splicing variants’ expressions might
be involved in tumorigenesis and metastasis in ESCC in a similar manner to
that of c-Met, and has a potential role as a disease and prognostic marker in
ESCC. Thus, the second objective of the present study is to assess the
expression of RON and its variants in patients with ESCC and to correlate
their levels with clinicopathological data. References: 1. Leonard EJ,
Danilkovitch A. Macrophage stimulating protein. Ad Cancer Res 2000; 77:
139-67. 2. Danilkovitch-Miagkova A, Leonard EJ. Anti-apoptotic action of
macrophage stimulating protein (MSP). Apoptosis 2001; 6(3): 183-90. 3. Ren Y,
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List of Research Outputs |
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Cense H.A., Law S.Y.K., Wei W.I., Lam L.K., Ng W.M., Wong K.H., Kwok K.F. and Wong J., Pharyngolaryngoesophagectomy using the thoracoscopic approach, Surgical Endoscopy. 2007, 21(6): 879-884. |
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Cheung C.M., Tang J.C.O., Lee P.Y., Hu L., Guan X.Y., Srivastava G., Wong J., Luk J.M.C. and Law S.Y.K., Establishment and characterization of a new xenograft-derived human esophageal squamous cell carcinoma cell line HKESC-4 of chinese origin, 11th Research Postgraduate Symposium (11th RPS), The University of Hong Kong Li Ka Shing Faculty of Medicine, Hong Kong, 7 December. 2006. |
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Chung M.F., Lam A.K.Y., Luk J.M.C., Law S.Y.K., Chan K.W., Lee P.Y. and Wong J., Clinical significance of e-cadherin and p120 catenin expression and localization in esophageal squamous cell carcinoma, 11th Research Postgraduate Symposium (11th RPS), The University of Hong Kong Li Ka Shing Faculty of Medicine, Hong Kong, 7 December. 2006. |
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Kwan K.L., Law S.Y.K., Wong K.H. and Kwok K.F., Esophageal hematoma: a masquerade of rare occurrence (Unusual cases and technical notes), Endoscopy. 2006, 38(S 5): E29. |
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Law S.Y.K., Ca oesophagus, Postgraduate Diploma in Advanced Nursing Practice - Intensive Care Nursing (for China Nurse), HKU School of Professional and Continuing Education, Hong Kong, 4 June. 2007. |
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Law S.Y.K., Chapter 33: Esophageal cancer: current staging classifications and techniques, endoscopic ultrasound, and laparoscopic and thoracoscopic staging, In: Yeo C.J., Dempsey D.T., Klein A.S., Pemberton J.H. & Peters J.H.(eds), Shackelford's Surgery of the Alimentary Tract, Sixth Edition, Volume I. USA, Elsevier, 2007, 448-464. |
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Law S.Y.K. and Wong J., Chapter 63: Esophagogastrectomy for carcinoma of the esophagus and gastric cardia, and the esophageal anastomosis, In: Fischer J.E., Bland K.I., Callery M.P., Clagett G.P., Jones D.B., LoGerfo F.W. & Seeger J.M.(eds), Mastery of Surgery, Fifth Edition, Volume One. USA, Lippincott Williams & Wilkins, 2007, 752-771. |
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Law S.Y.K. and Wong J., Chapter 9: Cancer of the esophagus, In: Zinner M.J.& Ashley S.W. (eds), Maingot's Abdominal Operations, Eleventh Edition. USA, The McGraw-Hill Company, Inc, 2007, 271-303. |
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Law S.Y.K., Current treatment for achalasia, Hong Kong Surgical Forum, Department of Surgery, University of Hong Kong Medical Centre, Queen Mary Hospital AND Hong Kong Chapter, American College of Surgeons, Hong Kong, 7-8 July. 2006. |
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Law S.Y.K., Detailing dysphagia, 4th PSGS Surgical Forum, Mandaluyong City, Philippines, 4-6 August. 2006. |
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Law S.Y.K., Esophageal cancer surgery: East vs. West, The Royal College of Surgeons of Edinburgh & The College of Surgeons of Hong Kong Conjoint Scientific Congress 2006, Hong Kong, 10-13 October. 2006. |
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Law S.Y.K., Esophageal surgery (Symposium: Does MIS offer advantages over open techniques? Evidence-based-medicine), International Society for Digestive Surgery, Rome, Italy, 29 November - 2 December. 2006. |
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Law S.Y.K., GE junction malignancy, 4th PSGS Surgical Forum, Mandaluyong City, Philippines, 4-6 August. 2006. |
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Law S.Y.K., Gastroesophageal reflux disease: the asian perspective, (Symposium: Modern Management of GERD), International Society for Digestive Surgrey, Rome, Italy, 29 November - 2 December. 2006. |
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Law S.Y.K. and Wong J., Lymph node dissection in surgical treatment of esophageal neoplasms, Surgical Oncology Clinics of North America . 2007, 16(1): 115-131. |
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Law S.Y.K., Management of CA oesophagus, Post-registration Certificate Course in Intensive Care Nursing, The Institute of Advanced Nursing Studies, Hospital Authority, Hong Kong, 2 August. 2006. |
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Law S.Y.K., Management of Ca oesophagus, Post-registration Certificate Course in Intensive Care Nursing, Department of Adult ICU, Queen Mary Hospital AND the Institute of Advanced Nursing Studies, Hospital Authority, Hong Kong, 12 July. 2006. |
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Law S.Y.K., Minimally invasive esophagectomy for cancer (Video Symposium: Esophageal Surgery), International Society for Digestive Surgery, Rome, Italy, 29 November - 2 December. 2006. |
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Law S.Y.K., Minimally invasive esophagectomy, First Joint Hangzhou / Hong Kong Surgical Convention, First Department of Surgery, Zhejiang University, Hangzhou, China, 14-15 January. 2007. |
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Law S.Y.K., Minimally invasive techniques for oesophageal cancer surgery, Best Practice & Research Clinical Gastroenterology. 2006, 20(5): 925-940. |
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Law S.Y.K., Multimodality treatment of esophageal cancer: current status, The Royal College of Surgeons of England, The College of Surgeons of Hong Kong, Conjoint Scientific Congress, Hong Kong, 6-7 May. 2007. |
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Law S.Y.K., Chen C., Wong K.H., Tong K.H. and Wong J., Siewert type III gastroesophageal junction tumor is an independent poor prognostic factor (Abstract), 1st Asia-Pacific Gastric Cancer Conference, Department of Surgery, National University of Singapore, Singapore, 20-22 November 2006. |
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Law S.Y.K., Kwong D.L.W., Wong K.H., Kwok K.F. and Wong J., The effects of neoadjuvant chemoradiation on pTNM staging and its prognostic significance in esophageal cancer, Journal of Gastrointestinal Surgery. 2006, 10(9): 1301-1311. |
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Law S.Y.K., Troublesome heartburn, 4th PSGS Surgical Forum, Mandaluyong City, Philippines, 4-6 August. 2006. |
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Tang W.K., Chui C.H., Fatima S., Kok S.H., Pak K.C., Ou T.M., Hui K.S., Wong M.M., Wong J., Law S.Y.K., Tsao G.S.W., Lam K.Y., Beh P.S., Srivastava G., Ho K.P., Chan A.S. and Tang J.C.O., Inhibitory effects of gleditsia sinensis fruit extract on telomerase activity and oncogenic expression in human esophageal squamous cell carcinoma, International Journal of Molecular Medicine. 2007, 19(6): 953-960. |
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Tang W.K., Chui C.H., Fatima S., Kok S.H., Pak K.C., Ou T.M., Hui K.S., Wong M.M., Wong J., Law S.Y.K., Tsao G.S.W., Lam K.Y., Beh P.S., Srivastava G., Chan A.S., Ho K.P. and Tang J.C.O., Oncogenic properties of a novel gene JK-1 located in chromosome 5p and its overexpression in human esophageal squamous cell carcinoma, International Journal of Molecular Medicine. 2007, 19(6): 915-923. |
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Tsang F., Law S.Y.K., Chau W.S., Chiu S.W.C. and Cheng L.C., A man with hemoptysis 3 years after bronchial stenting, CHEST 2006 the 72nd Annual International Scientific Assembly of the American College of Chest Physicians (ACCP), Salt Lake City, Utah, USA, 21-26 October 2006. |
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Wong J. and Law S.Y.K., Interdisciplinary management of cancer: the surgical perspective (Abstract), UICC World Cancer Congress 2006, Washington, DC, U.S.A., 8 - 12 July 2006 . 2006. |
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Wong J. and Law S.Y.K., Two approaches to cancer of the cardia, The Lancet Oncology. 2006, 7(8): 613-615. |
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Yuen H.F., Chan Y.P., Wong M.L.Y., Kwok W.K., Chan K.K., Lee P.Y., Srivastava G., Law S.Y.K., Wong Y.C., Wang X. and Chan K.W., Upregulation of Twist in oesophageal squamous cell carcinoma is associated with neoplastic transformation and distant metastasis, Journal of Clinical Pathology. 2006, 60(5): 510-514. |
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Zhang H., Jin Y., Chen X., Jin C., Law S.Y.K., Tsao G.S.W. and Kwong Y.L., Papillomavirus type 16 E6/E7 and human telomerase reverse transcriptase in esophageal cell immortalization and early transformation, Cancer Letters. 2007, 245(1-2): 184-194. |
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Researcher
: Law WL |
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Project Title: |
Self-expanding metallic stents for the poor patients with malignant colorectal obstruction |
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Investigator(s): |
Law WL, Chu KW |
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Department: |
Surgery |
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Source(s) of Funding: |
S.K. Yee Medical Foundation - General Award |
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Start Date: |
04/2004 |
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Abstract: |
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To provide the insertion of self-expanding metallic stents to the poor patients who cannot afford the devices. |
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List of Research Outputs |
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Chik B., Law W.L. and Choi H.K., Urinary retention after haemorrhoidectomy: impact of stapled haemorrhoidectomy, Asian Journal of Surgery. 2006, 29(4): 233-237. |
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Choi H.K., Law W.L. and Ho J.W.C., Leakage after resection and intraperitoneal anastomosis for colorectal malignancy: analysis of risk factors, Diseases of the Colon and Rectum. 2006, 49(11): 1719-1725. |
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Law W.L., Choi H.K., Lee Y.M., Ho J.W.C. and Seto C.L., Anastomotic leakage is associated with poor long-term outcome in patients after curative colorectal resection for malignancy, Journal of Gastrointestinal Surgery. 2007, 11: 8-15. |
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Law W.L., Lee Y.M., Choi H.K., Seto C.L. and Ho J.W.C., Impact of laparoscopic resection for colorectal cancer on operative outcomes and survival, Annals of Surgery. 2007, 245(1): 1-7. |
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Law W.L., Lee Y.M., Choi H.K., Seto C.L. and Ho J.W.C., Laparoscopic and open anterior resection for upper and mid rectal cancer: an evaluation of outcomes, Diseases of the Colon and Rectum. 2006, 49(8): 1108-1115. |
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Law W.L., Choi H.K., Lee Y.M. and Ho J.W.C., The impact of postoperative complications on long-term outcomes following curative resection for colorectal cancer, Annals of Surgical Oncology. 2007, 14(9): 2559-2566. |
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Lo O.S.H., Law W.L., Choi H.K., Lee Y.M., Ho J.W.C. and Seto C.L., Early outcomes of surgery for small bowel obstruction: analysis of risk factors, Langenbeck's Archives of Surgery. 2007, 392(2): 173-178. |
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Ng D.S., Chok K.S., Law W.L., Collins R.J. and Fan S.T., Long-term survival after resection of extrahepatic recurrence of hepatocellular carcinoma at the right colon, International Journal of Colorectal Disease. 2006, 22(11): 1411-1412. |
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Tong D.K. and Law W.L., Laparoscopic versus open right hemicolectomy for carcinoma of the colon, Journal of the Society of Laparoendoscopic Surgeons. 2007, 11(1): 76-80. |
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Researcher
: Lee EWM |
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List of Research Outputs |
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Chan S.C., Liu C.L., Lo C.M., Lam B.K.Y., Lee E.W.M. and Fan S.T., Donor quality of life before and after adult-to-adult right liver live donor liver transplantation, Liver Transplantation. 2006, 12(10): 1529-1536. |
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Chan S.C., Fan S.T., Liu C.L., Lo C.M., Lam B.K.Y. and Lee E.W.M., Working up donors for high-urgency and elective adult-to-adult live donor liver transplantation, Liver Transplantation. 2007, 13(4): 509-515. |
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Researcher
: Lee KW |
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Project Title: |
Identification of novel plasma RNA biomarkers of nasopharyngeal carcinoma for early detection of cancer |
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Investigator(s): |
Lee KW, Yuen PW |
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Department: |
Surgery |
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Source(s) of Funding: |
Small Project Funding |
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Start Date: |
09/2005 |
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Completion Date: |
08/2006 |
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Abstract: |
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Nasopharyngeal carcinoma (NPC) occurs sporadically in the west but is endemic in southern China (25 times higher than that in the western countries) with incidence rates of between 15 and 50 per 100,000 population (Ho, Int.J.Radiat.Oncol.Biol.Phys., 1978; 4:183-205). The median survival is less than 9 months for NPC patients presenting with distant metastasis (Teo et al., Cancer, 1991;67:434-439). More than half of patients are diagnosed late due to the absence of alarming early symptoms (Chan et al., Cancer, 1998; 82: 1003-1012). The diagnosis of NPC is often difficult because of the nonspecific nature of the clinical symptoms and difficulty in visualizing the nasopharynx. Obviously, there is an urgent need to develop a more sensitive and specific diagnostic method for early detection of NPC. Advances in molecular technology have provided us with many new tools for detecting small quantity of tumor-derived nucleic acid in the blood. The presence of DNA and RNA in plasma of cancer patients has been recognized since 1970s (Leon et al., Cancer Res.,1997; 37:646-650; Shapiro , et al., Cancer, 1983;51:2116-2120), but it was not until 1989 that neoplastic characteristics of plasma DNA in cancer patients were recognized. Five years later, Sorenson et al. (Sorenson et al., Cancer Epidemiol. Biomarkers Pre., 1997;3:67-71) reported the detection of tumor-derived oncogene mutation (k-ras) in pancreatic cancer, and Vasioukhin et al. (Vasioukhin et al., Br. J. Haematol., 1994; 86:774-779) reported N-ras mutations in myelodysplastic syndrome. These striking results provide an insight for the search of tumor marker in this non-invasive diagnostic approach. In tumor associated with viral infection, viral DNA has also been detected in plasma and serum (Yu et al., Clin. Cancer Res, 2004;10:1726-1732). Similar to the development of the circulating DNA field, the earliest efforts in the detection of circulating RNA focused on the detection of tumor-derived RNA in the plasma and serum of cancer patients. In 1999, two groups simultaneously achieved this goal by detection of tumor-derived RNA in patients with NPC and melanoma (Kopreski, Clin. Cancer Res., 1999; 5:1961-1965). One of the biggest surprises in the field of circulating RNA is that such RNA species are detectable at all in plasma or serum, considering the well-known instability of RNA. One may postulate that circulating RNA is probably protected from degradation through its association with apoptotic bodies (Lo et al, Ann.N.Y.Acad.Sci., 2004;1022:135-139). A number of RNA targets have been detected in the plasma and serum of cancer patients, including, RNA species associated with the various telomerase components and, CK19 and b-catenin gene (Silva et al., Clin. Cancer Res., 2001;7: 2821-2825; Wong et al., Clin. Cancer Res., 2004:10: 1613-1617). The stability of RNA in patients’ plasma has been confirmed by our lab. With modified RNA extraction protocol, we successfully amplified genes such as 18S and CK14. Diagnostically, the stability of circulating RNA has greatly enhanced its practicality as a molecular marker. Interestingly, patients suffering from NPC have increased levels of plasma RNA, when compared with healthy individuals. Therefore, we hypothesized that alterations of genes in patients’ plasma can be detected by cDNA microarray. cDNA microarray is a useful tool for studying genetic alterations in various cancers. However, gene expression profiling for NPC patients has not been reported due to absence of normal epithelial tissue as control. Based on the observation that increased levels of plasma RNA in NPC patients, array-based approach would be feasible for identification of novel biomarker in patients’ plasma for NPC. This part of project is designed to compare the genetic alterations in NPC patients’ blood plasma and normal healthy subjects by cDNA microarray. The main objective of this study is to identify novel tumor markers in clinical samples for early detection of NPC. |
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List of Research Outputs |
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Lee K.W., 2006 Young Scientist Award, Hong Kong Institution of Science. 2006. |
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Lee K.W., Poon R.T.P., Yuen P.W., Man K., Yang Z., Guan X.Y. and Fan S.T., Rac activation is associated with hepatocellular carcinoma metastasis by up-regulation of vascular endothelial growth factor expression, Clinical Cancer Research. 2006, 12(17): 5082-5089. |
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Lee K.W., Poon R.T.P., Yuen P.W., Ling M.T., Wang X., Wong Y.C., Guan X.Y., Man K., Tang Z.Y. and Fan S.T., Regulation of angiogenesis by Id-1 through hypoxia-inducible factor-1 mediated vascular endothelial growth factor up-regulation in hepatocellular carcinoma, Clinical Cancer Research. 2006, 12(23): 6910-6919. |
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Lee K.W., Man K., Poon R.T.P., Lo C.M., Yuen P.W., Ng I.O.L., Ng T.P., Leonard W. and Fan S.T., Signal transducers and activators of transcription 5b activation enhances hepatocellular carcinoma aggressiveness through induction of epithelial-mesenchymal transition, Cancer Research. 2006, 66(20): 9948-9956. |
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Lee K.W., The study of genetic pathways in HCC metastasis, Hong Kong International Cancer Congress, Hong Kong, 16 November 2006. 2006. |
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Lee K.W., Poon R.T.P., Yuen P.W., Ling M.T., Kwok W.K., Wang X., Wong Y.C., Guan X.Y., Man K., Chau K.L. and Fan S.T., Twist overexpression correlates with hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition, Clinical Cancer Research. 2006, 12(18): 5369-5376. |
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Ma S.K.Y., Chan K.W., Hu L., Lee K.W., Ng I.O.L., Wo Y.H., Zheng B. and Guan X.Y., Identification and characterization of tumorigenic liver cancer stem cells, Proceedings of the Annual Meeting of American Association for Cancer Research, Los Angeles, USA, April. 2007. |
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Ma S.K.Y., Chan K.W., Hu L., Lee K.W., Wo Y.H., Ng I.O.L., Zheng B. and Guan X.Y., Identification and characterization of tumorigenic liver cancer stem/progenitor cells, Gastroenterology. 2007, 132(7): 2542-2556. |
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Man K., Ng T.P., Xu A.M., Cheng Q., Sun B., Sun K.W., Lee K.W., Lo C.M., Poon R.T.P. and Fan S.T., Fat-derived hormone adiponectin suppresses liver tumor growth and metastases (Paper Presentation), The 98th Annual Meeting of the American Association for Cancer Research, Los Angeles, USA, 14 - 18 April 2007. |
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Ng
T.P., Man K., Sun K.W., Lee K.W., Poon R.T.P., Lo C.M. and Fan S.T., Clinicopathological
significance of homeoprotein Six |
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Ng
T.P., Man K., Ho J.W.Y., Sun K.W., Lee K.W., Zhao Y., Lo C.M., Poon R.T.P. and Fan S.T., Marked suppression of tumor
growth by FTY |
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Ng T.P., Man K., Cheng Q., Sun B., Lee K.W., Poon R.T.P., Lo C.M. and Fan S.T., Suppression of tumorigenesis and metastasis of hepatocellular of hepatocellular carcinoma by shRNA interference targeting on inhibition of homeoprotein Six1 (Paper Presentation), The 98th Annual Meeting of the American Association for Cancer Research, Los Angeles, USA, 14 - 18 April 2007. |
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Pang R.W.C., Lee K.W., Man K., Poon R.T.P., Fan S.T., Kwong Y.L. and Tse E.W.C., PIN1 expression contributes to hepatic carcinogenesis, Journal of Pathology. 2006, 210(1): 19-25. |
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Pang R.W.C., Lee K.W., Poon R.T.P., Fan S.T., Wong K.B., Kwong Y.L. and Tse E.W.C., Pin1 interacts with a specific serine-proline motif in hepatitis B virus X-protein to enhance hepatocarcinogenesis, Gastroenterology. 2007, 132(3): 1088-1103. |
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Researcher
: Lee KY |
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List of Research Outputs |
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Ngan E.S.W., Sit Y.L.F., Lee K.Y., Miao X., Yuan Z., Wang W.L., Nicholls J.M., Wong K.K.Y., Garcia-Barcelo M.M., Lui V.C.H. and Tam P.K.H., Implications of endocrine gland - derived vascular endothelial growth factor/prokineticin-1 signaling in human neuroblastoma progression., Clinical Cancer Research. 2007, 13(3): 868-875. |
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Ngan E.S.W., Lee K.Y., Sit Y.L.F., Poon H.C., Chan J.K.Y., Sham M.H., Lui V.C.H. and Tam P.K.H., Prokineticin-1 modulates proliferation and differentiation of enteric neural crest cells, Biochimica et Biophysica Acta. 2007, 1773(4): 536-545. |
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Ngan
E.S.W., Lee K.Y., Sit F.Y.L., Chan J.K.Y., Sham M.H., Lui V.C.H. and Tam P.K.H., Roles of Prokineticin |
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Researcher
: Lee PY |
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List of Research Outputs |
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Cheung C.M., Tang J.C.O., Lee P.Y., Hu L., Guan X.Y., Srivastava G., Wong J., Luk J.M.C. and Law S.Y.K., Establishment and characterization of a new xenograft-derived human esophageal squamous cell carcinoma cell line HKESC-4 of chinese origin, 11th Research Postgraduate Symposium (11th RPS), The University of Hong Kong Li Ka Shing Faculty of Medicine, Hong Kong, 7 December. 2006. |
|
Chung M.F., Lam A.K.Y., Luk J.M.C., Law S.Y.K., Chan K.W., Lee P.Y. and Wong J., Clinical significance of e-cadherin and p120 catenin expression and localization in esophageal squamous cell carcinoma, 11th Research Postgraduate Symposium (11th RPS), The University of Hong Kong Li Ka Shing Faculty of Medicine, Hong Kong, 7 December. 2006. |
|
Hui
C.K., Zhang H., Lee P.Y., Marin H., Yueng Y.H., Leung K.W., Lu L., Leung N., Luk J.M.C., Naoumov N., Huang F. and Lau G., Role of regulatory T cells in
natural immunity and sustained pharmacological control hepatitis B infection,
The Liver Meeting of The American Association for the Study of Liver, Hepatology.
2006, 44: |
|
Hui
C.K., Zhang H.Y., Lee P.Y.,
Mommeja-Marin H., Yueng Y.H., Leung K.W., Lu L., Leung N., Luk J.M.C., Naoumov N.N., Huang F.P. and
Lau G., Role of regulatory T cells in
natural immunity and sustained pharmacological control of chronic hepatitis B
infection, Hepatology. 2006, 44(4): |
|
Lee P.Y., Leung K.W., Wo J.Y., Tam P.C., Yeung W.S.B. and Luk J.M.C., Blockage of testicular connexins induced apoptosis in rat seminiferous spithelium, Apoptosis. 2006, 11: 1215-1229. |
|
Lee
P.Y., Mruk D.D., Xia W. and Cheng C.Y.,
Cellular localization of sphingomyelin synthase |
|
Lee P.Y. and Cheng P.Y., Junction Dynamics and Spermatogenesis, In: Cheng CY, Molecular Mechanisms in Spermatogenesis. Landes Bioscience, 2007, available in http://eurekah.com/chapter/3330. |
|
Lee P.Y., Yeung W.S.B. and Luk J.M.C., Junction interaction in the seminiferous epithelium: regulatory roles of connexin-based gap junction, Frontiers In Bioscience. 2007, 12: 1552-1562. |
|
Lee P.Y., Proteomic expression profiling of mouse liver: fom embryo to adult stages (Oral Paper Presentation), Hong Kong Surgical Forum, Department of Surgery, The University of Hong Kong, Hong Kong, 14 - 15 July 2006. |
|
Lee P.Y., Cheung N., Lam B.Y.H., Sham P., Lau G., Fan S.T., Luk J.M.C. and Luk J.M.C., Proteomics of mouse liver from embryo to adult: a lesion for HCC (Abstract), The 17th Asian Pacific Association for the Study of the Liver Conference, Kyoto, Japan, 27 - 30 March 2007. Hepatology International. 2007, 1(1): 21. |
|
Lee P.Y., Proteomics of mouse liver from embryo to adult: a lession for HCC (2007), APASL Conference, Kyoto, Japan, 27 - 31 March 2007. |
|
Luk J.M.C., Lee P.Y., Shum K.Y., Siu A.F.M., Che C.M., Tam P.C., Cheung A.N.Y., Yang Z.M., Lin Y.N., Matzuk M.M., Lee C.K.F. and Yeung W.S.B., Acrosome-Specific Gene AEP1: Identification, Characterization and Roles in Spermatogenesis , Journal of Cellular Physiology . 2006, 209: 755-766. |
|
Luk J.M.C., Zhang Q.S., Lee P.Y., Wo Y.H., Leung P.L., Liu L.X., Hu M.Y., Cheung K.F., Hui C.K., Lau G. and Fan S.T., Hepatic stellate cell-targeted delivery of M6P-HSA-glycyrrhetinic acid attenuates hepatic fibrogenesis in a bile duct ligation rat model, Liver International. 2007, 27(4): 548-557. |
|
Luk J.M.C., Yi X., Lee P.Y., Guan X.Y., Lau G. and Fan S.T., Mortalin-2 is an accurate prognostic biomarker for early recurrence of liver carcinoma (Abstract), The 17th Asian Pacific Association for the Study of the Liver Conference, Kyoto, Japan, 27 - 30 March 2007. Hepatology International. 2007, 1(1): 68. |
|
Yuen H.F., Chan Y.P., Wong M.L.Y., Kwok W.K., Chan K.K., Lee P.Y., Srivastava G., Law S.Y.K., Wong Y.C., Wang X. and Chan K.W., Upregulation of Twist in oesophageal squamous cell carcinoma is associated with neoplastic transformation and distant metastasis, Journal of Clinical Pathology. 2006, 60(5): 510-514. |
|
Zhang H., Hui C.K., Lee P.Y., Chan W., Yueng Y.H., Leung K.W., Lu L., Leung N., Lo C.M., Fan S.T., Luk J.M.C., Xu A., Lam K.S.L., Kwong Y.L. and Lau G., Serum adiponectin is increased in advancing liver fibrosis and decline with reduction in fibrosis in chronic hepatitis B, The 17th Asian Pacific Association for the Study of the Liver Conference, Kyoto, Japan, 27 - 30 March 2007, Hepatology International. 2007, 242: 7. |
|
Researcher
: Lee PY |
|
Project Title: |
Tight-junction
claudin |
|
Investigator(s): |
Lee PY, Luk JMC, Tam PC |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2004 |
|
Abstract: |
|
To isolate, identify and characterize a novel tight-junction molecule, claudin 19, which was initially found highly expressed in kidney. |
|
Project Title: |
Molecular analysis of a novel signaling molecule VAD1.2 highly conseved in mammalian germ cells |
|
Investigator(s): |
Lee PY |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
09/2005 |
|
Abstract: |
|
Germ cells are "stem-like" cell types capable of self-renewal and differentiation into highly specialized fertilizing cell types, resulting in the formation of spermatozoa during spermatogenesis (Cheng and Mruk, 2002). Haploid germ cells are initially resided on the basal lamina of the seminiferous epithelium in the testes and they migrate towards the lumens after passing through the tight junctions for further developments and maturations (Cheng and Mruk, 2002). In this process, the cell-cell associations and dissociations, the restructurings of the junctions and their linked underlying cytoskeletons, and the regulations of gene expressions are noted. As such, different gene expression profiles can be observed at different stages of germ cell development, making it interesting to study the arrays of gene expressions. However, it will be techically difficult and tedious to isolate germ cells originated in different stages. For instance, one can manually isolate different spermatogenic stages based on their distinct transillumination properties under stereomicroscope (Chen et al, 2003; Parvinen and Vanha-Perttula, 1972). In order to simplify the procedure for the study of gene regulations in different germ cell types in the testis, vitamin A-deficiency (VAD) and post-vitamin A replenishment (PVA) rat model and differential display reverse transcription-polymerase chain reaction (RT-PCR) are used to isolate and identify stage- or cell type-specific genes in the testis (Luk et al, 2003). In this model, adult rats are first fed with vitamin A-deficient diets, which leads to the spermatogenesis arrest and subsequent germ cell depletion from the epithelium (Luk et al, 2003; Lee et al, 2004). At that time, spermatogonia and preleptotene spermatocytes are the only two germ cell types found in the seminiferous tubules (Luk et al, 2003; Lee et al, 2004). Spermatogenesis is resumed in these rats by treating them with retinol, which can stimulate the proliferative activity of spermatogonia and their development to advanced germ cell types, resulting in the synchronization of the spermatogenic stages (van Pelt and de Rooij, 1990, 1991). Testes were isolated from different post-treatment days and subjected for differential display (Luk et al, 2003). As such, a number of differentially expressed genes, such as VAD 1.2, VAD 1.3, VAD 3.4, and VAD 28, were identified (Luk et al, 2003). Among those genes, VAD 1.2 was selected for further characterization, since it was found largely in advanced germ cell types (Luk et al, 2003). Advanced germ cells take part in several important cellular processes, such as spermiogenesis and spermiation, making them as one of the most essential cell types in coordinating these processes for turning germ cells into mature spermatozoa. The production of a mature and functional spermatozoan will be a critical step for successful fertilization. As such, the understanding of genes associated with these advanced germ cells and their functions are one of the important preliminary parameters for further understanding infertility and for the development of the its diagnosis and treatment. References:Chen YM, Lee NP, Mruk DD, Lee WM, Cheng CY (2003) Fer kinase/FerT and adherens junction dynamics in the testis: an in vitro and in vivo study. Biol Reprod 69: 656-672Cheng CY, Mruk DD (2002) Cell junction dynamics in the testis: Sertoli-germ cell interactions and male contraceptive development. Physiol Rev 82: 825-874 Lee KF, Yeung WS, Chow JF, Shum CK, Luk JM (2004) Different testicular gene expression patterns in the first spermatogenic cycle of postnatal and vitamin A-deficient rat testis. Biol Reprod 70: 1010-1017Luk JM, Mok BW, Shum CK, Yeung WS, Tam PC, Tse JY, Chow JF, Woo J, Kam K, Lee KF (2003) Identification of novel genes expressed during spermatogenesis in stage-synchronized rat testes by differential display. Biochem Biophys Res Commun 307: 782-790Parvinen M, Vanha-Perttula T (1972) Identification and enzyme quantitation of the stages of the seminiferous epithelial wave in the rat. Anat Rec 174: 435-449van Pelt AM, de Rooij DG (1990) Synchronization of the seminiferous epithelium after vitamin A replacement in vitamin A-deficient mice. Biol Reprod 43: 363-367van Pelt AM, de Rooij DG (1991) Retinoic acid is able to reinitiate spermatogenesis in vitamin A-deficient rats and high replicate doses support the full development of spermatogenic cells. Endocrinology 128: 697-704 |
|
List of Research Outputs |
|
Cheung C.M., Tang J.C.O., Lee P.Y., Hu L., Guan X.Y., Srivastava G., Wong J., Luk J.M.C. and Law S.Y.K., Establishment and characterization of a new xenograft-derived human esophageal squamous cell carcinoma cell line HKESC-4 of chinese origin, 11th Research Postgraduate Symposium (11th RPS), The University of Hong Kong Li Ka Shing Faculty of Medicine, Hong Kong, 7 December. 2006. |
|
Chung M.F., Lam A.K.Y., Luk J.M.C., Law S.Y.K., Chan K.W., Lee P.Y. and Wong J., Clinical significance of e-cadherin and p120 catenin expression and localization in esophageal squamous cell carcinoma, 11th Research Postgraduate Symposium (11th RPS), The University of Hong Kong Li Ka Shing Faculty of Medicine, Hong Kong, 7 December. 2006. |
|
Hui
C.K., Zhang H., Lee P.Y., Marin H., Yueng Y.H., Leung K.W., Lu L., Leung N., Luk J.M.C., Naoumov N., Huang F. and Lau G., Role of regulatory T cells in
natural immunity and sustained pharmacological control hepatitis B infection,
The Liver Meeting of The American Association for the Study of Liver, Hepatology.
2006, 44: |
|
Hui
C.K., Zhang H.Y., Lee P.Y.,
Mommeja-Marin H., Yueng Y.H., Leung K.W., Lu L., Leung N., Luk J.M.C., Naoumov N.N., Huang F.P. and
Lau G., Role of regulatory T cells in
natural immunity and sustained pharmacological control of chronic hepatitis B
infection, Hepatology. 2006, 44(4): |
|
Lee P.Y., Leung K.W., Wo J.Y., Tam P.C., Yeung W.S.B. and Luk J.M.C., Blockage of testicular connexins induced apoptosis in rat seminiferous spithelium, Apoptosis. 2006, 11: 1215-1229. |
|
Lee
P.Y., Mruk D.D., Xia W. and Cheng C.Y.,
Cellular localization of sphingomyelin synthase |
|
Lee P.Y. and Cheng P.Y., Junction Dynamics and Spermatogenesis, In: Cheng CY, Molecular Mechanisms in Spermatogenesis. Landes Bioscience, 2007, available in http://eurekah.com/chapter/3330. |
|
Lee P.Y., Yeung W.S.B. and Luk J.M.C., Junction interaction in the seminiferous epithelium: regulatory roles of connexin-based gap junction, Frontiers In Bioscience. 2007, 12: 1552-1562. |
|
Lee P.Y., Proteomic expression profiling of mouse liver: fom embryo to adult stages (Oral Paper Presentation), Hong Kong Surgical Forum, Department of Surgery, The University of Hong Kong, Hong Kong, 14 - 15 July 2006. |
|
Lee P.Y., Cheung N., Lam B.Y.H., Sham P., Lau G., Fan S.T., Luk J.M.C. and Luk J.M.C., Proteomics of mouse liver from embryo to adult: a lesion for HCC (Abstract), The 17th Asian Pacific Association for the Study of the Liver Conference, Kyoto, Japan, 27 - 30 March 2007. Hepatology International. 2007, 1(1): 21. |
|
Lee P.Y., Proteomics of mouse liver from embryo to adult: a lession for HCC (2007), APASL Conference, Kyoto, Japan, 27 - 31 March 2007. |
|
Luk J.M.C., Lee P.Y., Shum K.Y., Siu A.F.M., Che C.M., Tam P.C., Cheung A.N.Y., Yang Z.M., Lin Y.N., Matzuk M.M., Lee C.K.F. and Yeung W.S.B., Acrosome-Specific Gene AEP1: Identification, Characterization and Roles in Spermatogenesis , Journal of Cellular Physiology . 2006, 209: 755-766. |
|
Luk J.M.C., Zhang Q.S., Lee P.Y., Wo Y.H., Leung P.L., Liu L.X., Hu M.Y., Cheung K.F., Hui C.K., Lau G. and Fan S.T., Hepatic stellate cell-targeted delivery of M6P-HSA-glycyrrhetinic acid attenuates hepatic fibrogenesis in a bile duct ligation rat model, Liver International. 2007, 27(4): 548-557. |
|
Luk J.M.C., Yi X., Lee P.Y., Guan X.Y., Lau G. and Fan S.T., Mortalin-2 is an accurate prognostic biomarker for early recurrence of liver carcinoma (Abstract), The 17th Asian Pacific Association for the Study of the Liver Conference, Kyoto, Japan, 27 - 30 March 2007. Hepatology International. 2007, 1(1): 68. |
|
Yuen H.F., Chan Y.P., Wong M.L.Y., Kwok W.K., Chan K.K., Lee P.Y., Srivastava G., Law S.Y.K., Wong Y.C., Wang X. and Chan K.W., Upregulation of Twist in oesophageal squamous cell carcinoma is associated with neoplastic transformation and distant metastasis, Journal of Clinical Pathology. 2006, 60(5): 510-514. |
|
Zhang H., Hui C.K., Lee P.Y., Chan W., Yueng Y.H., Leung K.W., Lu L., Leung N., Lo C.M., Fan S.T., Luk J.M.C., Xu A., Lam K.S.L., Kwong Y.L. and Lau G., Serum adiponectin is increased in advancing liver fibrosis and decline with reduction in fibrosis in chronic hepatitis B, The 17th Asian Pacific Association for the Study of the Liver Conference, Kyoto, Japan, 27 - 30 March 2007, Hepatology International. 2007, 242: 7. |
|
Researcher
: Lee YM |
|
List of Research Outputs |
|
Law W.L., Choi H.K., Lee Y.M., Ho J.W.C. and Seto C.L., Anastomotic leakage is associated with poor long-term outcome in patients after curative colorectal resection for malignancy, Journal of Gastrointestinal Surgery. 2007, 11: 8-15. |
|
Law W.L., Lee Y.M., Choi H.K., Seto C.L. and Ho J.W.C., Impact of laparoscopic resection for colorectal cancer on operative outcomes and survival, Annals of Surgery. 2007, 245(1): 1-7. |
|
Law W.L., Lee Y.M., Choi H.K., Seto C.L. and Ho J.W.C., Laparoscopic and open anterior resection for upper and mid rectal cancer: an evaluation of outcomes, Diseases of the Colon and Rectum. 2006, 49(8): 1108-1115. |
|
Law W.L., Choi H.K., Lee Y.M. and Ho J.W.C., The impact of postoperative complications on long-term outcomes following curative resection for colorectal cancer, Annals of Surgical Oncology. 2007, 14(9): 2559-2566. |
|
Lo O.S.H., Law W.L., Choi H.K., Lee Y.M., Ho J.W.C. and Seto C.L., Early outcomes of surgery for small bowel obstruction: analysis of risk factors, Langenbeck's Archives of Surgery. 2007, 392(2): 173-178. |
|
Researcher
: Lee YT |
|
List of Research Outputs |
|
Cheung S.T., Fan S.T., Lee Y.T., Ng I.O.L. and Lo C.M., Biomarker in relation to post-transplant recurrence in liver cancer patients (Abstract), The 2nd Nanjing-Hong Kong Liver Transplantation Symposium, Nanjing, China, 25 - 27 August 2006. |
|
Cheung S.T., Liu C.L., Chow J.P.H., Lee Y.T., Ip Y.C., Ho J.C.Y. and Fan S.T., Preoperative plasma transcript AA454543 level is an independent prognostic factor for hepatocellular carcinoma after partial hepatectomy, Neoplasia. 2006, 8(9): 696-701. |
|
Ho J.C.Y., Cheung S.T., Poon W.S., Lee Y.T., Ng I.O.L. and Fan S.T., Down-regulation of retinol binding protein 5 is associated with aggressive tumor features in hepatocellular carcinoma, Journal of Cancer Research and Clinical Oncology. 2007. |
|
Researcher
: Leon YY |
|
List of Research Outputs |
|
Lui V.C.H., Cheng W.C., Leon Y.Y., Lau K.C., Garcia-Barcelo M.M., Miao X., Wall N. and Tam P.K.H., HOXB5 regulates the expression of RET in ENS: a novel Hirschsprung's gene, The 40th Annual Meeting of the Pacific Association of Paediatric Surgeons together with the Annual Scientific Meeting of the Australasian Association of Paediatric Surgeons, Queenstown, New Zealand, 15-19 April 2007. |
|
Miao X., Garcia-Barcelo M.M., So M.T., Leon Y.Y., Lau K.C., Liu T., Chan E.K.W., Lan L.C.L., Wong K.K.Y., Lui V.C.H. and Tam P.K.H., Role of RET and PHOX2B gene polymorphisms in risk of Hirschsprung's disease in Chinese population, Gut. 2007, 56(5): 736. |
|
Researcher
: Leung GKK |
|
Project Title: |
A prospective study on platelet functions in neurosurgical patients receiving acetylsalicylic acid (aspirin). |
|
Investigator(s): |
Leung GKK, Ng JKF, Fan YW |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
12/2005 |
|
Abstract: |
|
OBJECTIVE To assess platelet functions in hospitalized neurosurgical patients who receive aspirin immediately prior to admission. BACKGROUND Acetylsalicylic acid, or aspirin, is commonly used for the treatment of thrombotic vascular diseases such as coronary artery disease or cerebrovascular diseases. Aspirin-users may sometimes present with concurrent neurosurgical conditions, such as brain tumours and intracranial haemorrhages. Aspirin, by impairing platelet functions, may cause clinical deterioration or severe intra-operative haemorrhages in these patients. [1-2] In stable patients, it is current neurosurgical practice to withhold aspirin and to post-pone surgery until platelet functions normalize. In unstable patients, it may be necessary to proceed with immediate surgery despite impaired platelet functions. Attempts would be made in the latter situation to improve haemostasis by means of platelet transfusion. [3] Patients on aspirin, however, represent a heterogeneous population. Although the pharmacokinetics and pharmacodynamics of aspirin have been well studied, the actual clinical effect within and between individuals may vary widely due to differences in dosage, individual response, treatment duration and compliance. For an individual taking aspirin who presents with a neurosurgical condition, there is no reliable clinical method to assess platelet functions, or to ascertain if it is safe to proceed with immediate surgery, or for how long surgery should be withheld. The clinical effects of empirical corrective measures such as platelet transfusion are also unknown. Platelet functions can be assessed quantitatively using PFA-100® analyzer, which is a newly developed and validated method for the monitoring of various platelet dysfunctions. It requires venous whole blood samples only, and unlike the template bleeding-time method, PFA-100® analysis is more accurate and reproducible, and do not leave any extra scars. Actual aspirin consumption in patients who give a drug history of aspirin usage can be verified using serum thromboxaneB2 level analysis. [4-6] We therefore design this study to address the following questions, using PFA-100® and thromboxaneB2 level analysis as quantitative assessment of platelet functions and consumption: QUESTIONS TO BE ANSWERED • To what extent do PFA-100® results vary amongst patients who give history of aspirin consumption immediately prior to hospital admission? • How do PFA-100® results change after cessation of aspirin consumption? And can the changes be formulated using clinically applicable parameters such as body size, age and aspirin dosage? • To what extent does platelet transfusion alter PFA-100® results in aspirin- users. REFERENCES 1. Palmer JD, Sparrow OC, Iannotti F. Postoperative Hematoma: A 5-Year Survey and Identification of Avoidable Risk Factors. Neurosurgery 1994;36:1061-1065. 2. Stroobandt G, Fransen P, Thauvoy C, Menato hospital enetic factors in chronic subdural haematoma and causes of recurrence after drainage. Acta Neurochir (Wien) 1995;137:6-14. 3. Harder S, Klinkhardt U, Alvarez JM. Avoidance of bleeding during surgery in patients receiving anticoagulant and/or antiplatelet therapy: pharmacokinetic and pharmacodynamic considerations. Clin Pharmacokinet 2004; 43:963-981.- 4. Goh KY, Tsoi WC, Feng CS, Wickham N, Poon WS. Haemostatic changes during surgery for primary brain tumours. J Neurol Neurosurg Psychiatry 1997; 63: 334-338. 5. Favaloro EJ. Clinical application of the PFA-100. Curr Opin Hematol 2002; 9:407-415. 6. Jacoby RC, Owings JT, Holmes J, Battistella FD, Gosselin RC, Paglieroni TG. Platelet activation and function after trauma. J Trauma 2001; 51:639-647. |
|
List of Research Outputs |
|
Hussaini I.M., Trotter C., Zhao Y., Abdel-Fattah R., Amos S., Xiao A., Agi C.U., Redpath G.T., Fang Z., Leung G.K.K. and Lopes M.B., Matrix metalloproteinase-9 is differentially expressed in nonfunctioning invasive and noninvasive pituitary adenomas and increases invasion in human pituitary adenoma cell line, American Journal of Pathology. 2007, 170(1): 356-365. |
|
Lee R., Lui W.M., Cheung R.T.F., Leung G.K.K. and Chan K.H., Mechanical thrombectomy in acute proximal middle cerebral artery thrombosis with the Alligator Retrieval Device, Cerebrovascular Diseases. 2007, 23: 69-71. |
|
Leung G.K.K., “Stem Cells – from bench to bedside” – Neurological application. , Medical Diary. 2007, 12: 26. |
|
Leung G.K.K., Ng K.B., Ng J.K.F. and Hung K.N., Best Oral Poster Presentation. Title: 'Initial experience with the PFA-100® analyzer in neurosurgical patients taking aspirin.', Annual Scientific Meeting2006, Hong Kong Neurosurgical Society, Hong Kong, 8 - 9 December 2006. 2006. |
|
Leung G.K.K., Brainstem death [Invited lecture],, Post-registration Certificate Course on Perioperative Nursing, Institute of Advanced Nursing Studies. 2006. |
|
Leung G.K.K., Ng J.K.F. and Hung K.N., Initial experience with the PFA-100® analyzer in neurosurgical patients taking aspirin. , Annual Scientific Meeting 2006. Hong Kong Neurosurgical Society, Hong Kong, 8 - 9 December 2006. |
|
Leung G.K.K., Stem Cells therapy in neuro-regeneration [Invited lecture], The 4th Congress of Federation of Asian-Oceanian Neuroscience Societies (FAONS), Hong Kong, 30 November - 2 December 2006. 2006. |
|
Leung G.K.K., Surgery for Brain Metastasis: the Queen Mary Hospital Experience [Invited lecture], Hong Kong International Cancer Congress, 11 November 2006. 2006. |
|
Leung G.K.K., Ho Y.C.W. and Yuen W.K., The Effect of Inter-hospital Transfer on the Outcome of Trauma Patients , RSCEd/CSHK Conjoint Scientific Congress, Hong Kong, 12 October 2006. |
|
Leung G.K.K., The Trauma Injury Severity Socre (TRISS) is a predictor of mortality in patients with severe but no moderate or mild head injury, Conjoint Meeting of the College of Surgeons of Hong Kong and the Royal College of Surgeons of England, 6 May 2007. |
|
Leung G.K.K., Three years' outcome from five trauma centres in Hong Kong, Hospital Authority Convention 2007, Hong Kong, 8 May 2007. |
|
Leung S.C.M., Leung G.K.K., Ng K.B. and Hung K.N., Surgery for Brain Metastasis: the Queen Mary Hospital Experience , Annual Scientific Meeting 2006, Hong Kong Neurosurgical Society, Hong Kong, 8 - 9 December 2006. |
|
Li. Lai Fung , Cheung R.T.F. and Leung G.K.K., Relations between intracerebral space-occupying lesions and autonomic activities in terms of heart rate variability (HRV) by 24hr Holter machine, Annual Scientific Meeting of the Hong Kong Neurosurgical Society, Hong Kong, 8 - 9 December 2006. |
|
Tse, Yat Hang and Leung G.K.K., Wu E.X., Preliminary results of sequential diffusion tensor imaging (DTI) assessment of white fiber tract integrity in head-injured rats, Annual Scientific Meeting of the Hong Kong Neurosurgical Society, Hong Kong, 8 - 9 December 2006. |
|
Researcher
: Leung KW |
|
List of Research Outputs |
|
Lee P.Y., Leung K.W., Wo J.Y., Tam P.C., Yeung W.S.B. and Luk J.M.C., Blockage of testicular connexins induced apoptosis in rat seminiferous spithelium, Apoptosis. 2006, 11: 1215-1229. |
|
Researcher
: Leung LS |
|
List of Research Outputs |
|
Ho K.L., Yip A.W.C., Leung L.S. and Law I.C., Surgical treatment of penile curvature, Hong Kong Medical Journal. 2006, 12(6): 410-414. |
|
Researcher
: Leung PL |
|
List of Research Outputs |
|
Hwang I.S.S., Tang F., Leung P.L., Li Y.Y., Fan S.T. and Luk J.M.C., The gene expression of adrenomedullin, calcitonin-receptor-like receptor and receptor activity modifying proteins (RAMPs) in CCl(4)-induced rat liver cirrhosis, Regulatory Peptides. 2006, 135(1-2): 69-77. |
|
Luk J.M.C., Zhang Q.S., Lee P.Y., Wo Y.H., Leung P.L., Liu L.X., Hu M.Y., Cheung K.F., Hui C.K., Lau G. and Fan S.T., Hepatic stellate cell-targeted delivery of M6P-HSA-glycyrrhetinic acid attenuates hepatic fibrogenesis in a bile duct ligation rat model, Liver International. 2007, 27(4): 548-557. |
|
Wang X., Luk J.M.C., Garcia-Barcelo M.M., Miao X., Leung P.L., Ho D.W.Y., Cheung S.T., Lam B.Y.H., Cheung C.K.Y., Wong S.Y., Lau S.S.M., So M.T., Yu W.C., Cai Q., Liu K.S.Y., Hui C.K., Lau G., Poon R.T.P., Wong J. and Fan S.T., Liver intestine-cadherin (CDH17) haplotype is associated with increased risk of hepatocellular carcinoma, Clinical Cancer Research. 2006, 12(17): 5248-5252. |
|
Researcher
: Li GKH |
|
List of Research Outputs |
|
So K.W., Marsh G., Ling W.M., Leung F.Y., Lo J.C.K., Yeung M. and Li G.K.H., Impact of the symptom cluster on quality of life among Chinese women with breast cancer undergoing cancer treatment, Frontiers in Biomedical Research HKU 2006 . 2006. |
|
Researcher
: Li X |
|
List of Research Outputs |
|
Chen Y., Li X., Tian L., Lui V.C.H., Dallman M.J., Lamb J.R. and Tam P.K.H., Inhibition of sonic hedgehog signaling reduces chronic rejection and prolongs allograft survival in a rat orthotopic small bowel transplantation model, Transplantation. 2007, 83(10): 1351-1357. |
|
Li X., The mechanism study of novel approaches to control chronic allograft rejection in rat orthotopic small bowel transplantation, Thesis, Doctor of Philosophy. 2006. |
|
Researcher
: Lin C |
|
Project Title: |
The role of DC-SIGN in the regulation of dendritic cell function and T cell responses: from HIV immunopathology to the induction of peripheral T cell tolerance |
|
Investigator(s): |
Lin CL |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
11/2002 |
|
Abstract: |
|
The project attempts to characterize the role of DC-DIGN in the regulation of dendritic cell function, and to evaluate the inhibitory effect of DC-SIGN-modulated DC on T cell responses to primary and recall antigens in vitro and in vivo. This study will provide critical insights into the molecular mechanisms whereby DC-SIGN contributes to immunosuppression or peripheral tolerance, which may allow us to design more effective strategies for antiviral therapies and the induction of transplantation tolerance. |
|
Project Title: |
The effect of SARS-associated coronavirus Spike protein on immune regulation of SARS |
|
Investigator(s): |
Lin CL, Chan VSF |
|
Department: |
Surgery |
|
Source(s) of Funding: |
VCO SARS Research Fund |
|
Start Date: |
07/2003 |
|
Abstract: |
|
To delineate the immune regulatory mechanisms in the afferent and efferent phases of immune responses against SARS-CoV (Severe Acute Respiratory Syndrome Coronavirus) infection. |
|
Project Title: |
Development of DNA and viral vector vaccines against Epstein-Barr virus-positive nasopharyngeal carcinoma |
|
Investigator(s): |
Lin CL |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
09/2003 |
|
Abstract: |
|
To design and parpare DNA vaccine encoding EBNA1 and LMP2, and the MVA vaccine encoding the cytokine GM-CSF, the chemokine RANTES, the EBV- specific lytic antigen EBNA-1, and EBV-specific latent antigen LMP2; to identify the efficacy of these vaccines in vitro on their capacity in attracting dendritic cells and also in the induction of EBNA-1 specific CD4+T cell response and LMP2-specific CTL immunity; to verify the efficacy of these vaccines in a mouse NPC and a B cell lymphoma model, including the potency of CD4+ and CTL immunity, and also to test the effect of the dosage, route, and the effect of combinational use of both the DNA and MVA vaccines. |
|
Project Title: |
Development and clinical evaluation of peptide vaccines for immunotherapy of Epstein-Barr virus-positive nasopharyngeal carcinoma |
|
Investigator(s): |
Lin CL, Tam PKH, Che CM |
|
Department: |
Surgery |
|
Source(s) of Funding: |
NSFC/RGC Joint Research Scheme |
|
Start Date: |
12/2004 |
|
Abstract: |
|
To design and prepare peptide vaccines composed of novel peptide analogues of the Epstein-Barr virus (EBV)-specific antigen latent membrane protein 2 (LMP2), EBV-specific nuclear antigen type 1 (EBNA1), the DC-specific monocyte-derived chemokine (MDC), and the dendritic cell (DC) activator CD40 ligand; to assess the efficacy of this peptide vaccine in vitro and in vivo in a NOD/SCID mouse model in terms of the capacity in attracting DCs and inducing LMP2- and EBNA1-specific T cell immunity; to conduct a phase I clinical trial to verify in vivo the efficacy of peptide vaccine in human subjects, including the safety and toxicity, the EBV-specific CD4 and CD8 T cell responsiveness, and the effect of the dosage and regimen in boosting and maintaining the longevity of effective T cell immunity. |
|
List of Research Outputs |
|
Researcher
: Lin CL |
|
Project Title: |
The role of DC-SIGN in the regulation of dendritic cell function and T cell responses: from HIV immunopathology to the induction of peripheral T cell tolerance |
|
Investigator(s): |
Lin CL |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
11/2002 |
|
Abstract: |
|
The project attempts to characterize the role of DC-DIGN in the regulation of dendritic cell function, and to evaluate the inhibitory effect of DC-SIGN-modulated DC on T cell responses to primary and recall antigens in vitro and in vivo. This study will provide critical insights into the molecular mechanisms whereby DC-SIGN contributes to immunosuppression or peripheral tolerance, which may allow us to design more effective strategies for antiviral therapies and the induction of transplantation tolerance. |
|
Project Title: |
The effect of SARS-associated coronavirus Spike protein on immune regulation of SARS |
|
Investigator(s): |
Lin CL, Chan VSF |
|
Department: |
Surgery |
|
Source(s) of Funding: |
VCO SARS Research Fund |
|
Start Date: |
07/2003 |
|
Abstract: |
|
To delineate the immune regulatory mechanisms in the afferent and efferent phases of immune responses against SARS-CoV (Severe Acute Respiratory Syndrome Coronavirus) infection. |
|
Project Title: |
Development of DNA and viral vector vaccines against Epstein-Barr virus-positive nasopharyngeal carcinoma |
|
Investigator(s): |
Lin CL |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
09/2003 |
|
Abstract: |
|
To design and parpare DNA vaccine encoding EBNA1 and LMP2, and the MVA vaccine encoding the cytokine GM-CSF, the chemokine RANTES, the EBV- specific lytic antigen EBNA-1, and EBV-specific latent antigen LMP2; to identify the efficacy of these vaccines in vitro on their capacity in attracting dendritic cells and also in the induction of EBNA-1 specific CD4+T cell response and LMP2-specific CTL immunity; to verify the efficacy of these vaccines in a mouse NPC and a B cell lymphoma model, including the potency of CD4+ and CTL immunity, and also to test the effect of the dosage, route, and the effect of combinational use of both the DNA and MVA vaccines. |
|
Project Title: |
Development and clinical evaluation of peptide vaccines for immunotherapy of Epstein-Barr virus-positive nasopharyngeal carcinoma |
|
Investigator(s): |
Lin CL, Tam PKH, Che CM |
|
Department: |
Surgery |
|
Source(s) of Funding: |
NSFC/RGC Joint Research Scheme |
|
Start Date: |
12/2004 |
|
Abstract: |
|
To design and prepare peptide vaccines composed of novel peptide analogues of the Epstein-Barr virus (EBV)-specific antigen latent membrane protein 2 (LMP2), EBV-specific nuclear antigen type 1 (EBNA1), the DC-specific monocyte-derived chemokine (MDC), and the dendritic cell (DC) activator CD40 ligand; to assess the efficacy of this peptide vaccine in vitro and in vivo in a NOD/SCID mouse model in terms of the capacity in attracting DCs and inducing LMP2- and EBNA1-specific T cell immunity; to conduct a phase I clinical trial to verify in vivo the efficacy of peptide vaccine in human subjects, including the safety and toxicity, the EBV-specific CD4 and CD8 T cell responsiveness, and the effect of the dosage and regimen in boosting and maintaining the longevity of effective T cell immunity. |
|
List of Research Outputs |
|
Researcher
: Liu CL |
|
Project Title: |
The significance of intra-graft expression profile and ultrastructural features at early phase after liver transplantation-a prospective study of liver transplantation using cadaver and live donors |
|
Investigator(s): |
Liu CL, Man K |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2003 |
|
Abstract: |
|
To investigate the gene expression profiles of the donor and graft at the early phase after liver transplantation associated with hepatic ultrastructural features in liver transplantation using cadaver and live donors; to study the correlation of graft status, gene expression patterns with early and late clinical outcome functionally and morphologically. |
|
Project Title: |
Portal vein embolization before major right hepatic resection for hepatocellular carcinoma: a prospective randomized study |
|
Investigator(s): |
Liu CL, Fan ST, Tso WK |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2006 |
|
Abstract: |
|
To evaluate the role of preoperative PVE in patients undergoing major right hepatic resection for HCC, and to determine whether the treatment can result in reduction of postoperative morbidities of these patients by a prospective randomized trial. |
|
List of Research Outputs |
|
Au W.Y., Fung A., Liu C.L., Fan S.T., Ma E.S.K., Liang R.H.S. and Kwong Y.L., Serial analysis of JAK2 mutation in a patient who developed essential thrombocythemia after orthotopic liver transplantation (Case Report), American Journal of Hematology. 2006, 81(11): 880-882. |
|
Au W.Y., Au W.Y., Fung T.K., Liu C.L., Fung T.K., Fung T.K., Fan S.T., Ma E.S.K., Liang R.H.S. and Kwong Y.L., Serial analysis of JAK2 mutation in a patient who developed essential thrombocythemia after orthotopic liver transplantation, American Journal of Hematology. 2006, 81(1): 880-882. |
|
Chan A.O.O., Liu C.L. and Wong B.C.Y., Choledochal cysts. , In: Baron T, Kozarek R & Carr-Locke D (eds), A Practical Guide to ERCP. Elsevier, 2007. |
|
Chan S.C., Chik B., Liu C.L., Lo C.M. and Fan S.T., A decade of right liver adult-to-adult live donor liver transplantation: mid-term outcomes (Abstract), The International Liver Transplantation Society 13th Annual International Congress, Rio de Janeiro, Brazil, 20 - 23 June 2007. |
|
Chan S.C., Liu C.L., Lo C.M., Lam B.K.Y., Lee E.W.M. and Fan S.T., Donor quality of life before and after adult-to-adult right liver live donor liver transplantation, Liver Transplantation. 2006, 12(10): 1529-1536. |
|
Chan S.C., Fan S.T., Lo C.M. and Liu C.L., Effect of side and size of graft on surgical outcomes of adult-to-adult live donor liver transplantation, Liver Transplantation. 2007, 13(1): 91-98. |
|
Chan S.C., Fan S.T., Lo C.M., Liu C.L. and Wong J., Toward current standards of donor right hepatectomy for adult-to-adult live donor liver transplantation through the experience of 200 cases, Annals of Surgery. 2007, 245(1): 110-117. |
|
Chan S.C., Fan S.T., Liu C.L., Lo C.M., Lam B.K.Y. and Lee E.W.M., Working up donors for high-urgency and elective adult-to-adult live donor liver transplantation, Liver Transplantation. 2007, 13(4): 509-515. |
|
Cheung S.T., Liu C.L., Chow J.P.H., Lee Y.T., Ip Y.C., Ho J.C.Y. and Fan S.T., Preoperative plasma transcript AA454543 level is an independent prognostic factor for hepatocellular carcinoma after partial hepatectomy, Neoplasia. 2006, 8(9): 696-701. |
|
Chik B.H., Liu C.L., Fan S.T., Lo C.M., Poon R.T.P., Lam C.M. and Wong J., Tumor size and operative risks of extended right-sided hepatic resection for hepatocellular carcinoma: implication for preoperative portal vein embolization, Archives of Surgery. 2007, 142(1): 63-69. |
|
Fan
S.T., Lo C.M. and Liu C.L., Major hepatic resection
for primary and metastatic tumors, In: Fischer JE, Bland KI, Callery MP,
LoGerfo FW, Clagett GP, Seeger JM & Jones DB (eds), Mastery of
Surgery, 5th Edition. |
|
Liu C.L., Fan S.T., Cheung S.T., Lo C.M., Ng I.O.L. and Wong J., Anterior approach versus conventional approach right hepatic resection for large hepatocellular carcinoma: a prospective randomized controlled study, Annals of Surgery. 2006, 244(2): 194-203. |
|
Liu C.L., Hepatic resection for hepatocellular carcinoma, Hong Kong Medical Diary. 2006, 10(12): 15-17. |
|
Liu C.L., Fan S.T., Lo C.M., Tso W.K., Lam C.M. and Wong J., Improved operative and survival outcomes of surgical treatment for hilar cholangiocarcinoma, British Journal of Surgery. 2006, 93(12): 1488-1494. |
|
Lo C.M., Liu C.L., Chan S.C., Lam C.M., Poon R.T.P., Ng I.O.L., Fan S.T. and Wong J., A randomized, controlled trial of postoperative adjuvant interferon therapy after resection of hepatocellular carcinoma, Annals of Surgery. 2007, 245(6): 831-842. |
|
Lo C.M., Fan S.T., Liu C.L., Chan S.C., Ng I.O.L. and Wong J., Living donor versus deceased donor liver transplantation for early unresectable hepatocellular carcinoma, British Journal of Surgery. 2007, 94(1): 78-86. |
|
Poon
R.T.P., Fan S.T., Lo C.M., Liu C.L. and Wong J., Difference in tumor invasiveness
in cirrhotic patients with hepatocellular carcinoma fulfilling the |
|
Sun
K.W., Man K., Liu C.L., Poon R.T.P. and Fan S.T., The significance of Pyk |
|
Researcher
: Liu KSY |
|
List of Research Outputs |
|
Wang X., Luk J.M.C., Garcia-Barcelo M.M., Miao X., Leung P.L., Ho D.W.Y., Cheung S.T., Lam B.Y.H., Cheung C.K.Y., Wong S.Y., Lau S.S.M., So M.T., Yu W.C., Cai Q., Liu K.S.Y., Hui C.K., Lau G., Poon R.T.P., Wong J. and Fan S.T., Liver intestine-cadherin (CDH17) haplotype is associated with increased risk of hepatocellular carcinoma, Clinical Cancer Research. 2006, 12(17): 5248-5252. |
|
Researcher
: Liu T |
|
List of Research Outputs |
|
Miao X., Garcia-Barcelo M.M., So M.T., Leon Y.Y., Lau K.C., Liu T., Chan E.K.W., Lan L.C.L., Wong K.K.Y., Lui V.C.H. and Tam P.K.H., Role of RET and PHOX2B gene polymorphisms in risk of Hirschsprung's disease in Chinese population, Gut. 2007, 56(5): 736. |
|
Researcher
: Liu Y |
|
Project Title: |
A study of the effect of vascular endothelial growth factor tyrosine kinase inhibitor PTK 787/ZK222584 on liver fibrosis |
|
Investigator(s): |
Liu Y, Poon RTP |
|
Department: |
Centre for the Study of Liver Disease |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2004 |
|
Abstract: |
|
To investigate the effect of this drug on the development of liver fibrosis, which could potentially make a great contribution to the treatment of human liver fibrosis. |
|
List of Research Outputs |
|
Chen Y., Liu Y., Yuan Z., Tian L., Dallman M.J., Thompson P.W., Tam P.K.H. and Lamb J.R., Rosiglitazone suppresses cyclosporin-induced chronic transplant dysfunction and prolongs survival of rat cardiac allografts, Transplantation. 2007, 83(12): 1602-1610. |
|
Liu Y., Poon R.T.P., Shao W., Sun X., Chen H., Kok T.W. and Fan S.T., Blockage of epidermal growth factor receptor by quinazoline tyrosine kinase inhibitors suppresses growth of human hepatocellular carcinoma, Cancer Letters. 2007, 248(1): 32-40. |
|
Liu Y., Lei L., Lui E.L.H., Lau C.P.Y., Chen Y., Wo Y.H., Fan S.T. and Poon R.T.P., Tyrosine kinase inhibitor PTK 787/ZK222584 inhibits liver fibrosis (Abstract), The 17th Asian Pacific Association for the Study of the Liver Conference, Kyoto, Japan, 27 - 30 March 2007. Hepatology International. 2007, 1(1): 206. |
|
Yang Z., Poon R.T.P., Liu Y., Lau C.K., Ho D.W.Y., Tam K.H., Lam C.T. and Fan S.T., High doses of tyrosine kinase inhibitor PTK787 enhance the efficacy of ischemic hypoxia for the treatment of hepatocellular carcinoma: dual effects on cancer cell and angiogenesis, Molecular Cancer Therapeutics. 2006, 5(9): 2261-2270. |
|
Researcher
: Liu Y |
|
List of Research Outputs |
|
Chen Y., Liu Y., Yuan Z., Tian L., Dallman M.J., Thompson P.W., Tam P.K.H. and Lamb J.R., Rosiglitazone suppresses cyclosporin-induced chronic transplant dysfunction and prolongs survival of rat cardiac allografts, Transplantation. 2007, 83(12): 1602-1610. |
|
Liu Y., Poon R.T.P., Shao W., Sun X., Chen H., Kok T.W. and Fan S.T., Blockage of epidermal growth factor receptor by quinazoline tyrosine kinase inhibitors suppresses growth of human hepatocellular carcinoma, Cancer Letters. 2007, 248(1): 32-40. |
|
Liu Y., Lei L., Lui E.L.H., Lau C.P.Y., Chen Y., Wo Y.H., Fan S.T. and Poon R.T.P., Tyrosine kinase inhibitor PTK 787/ZK222584 inhibits liver fibrosis (Abstract), The 17th Asian Pacific Association for the Study of the Liver Conference, Kyoto, Japan, 27 - 30 March 2007. Hepatology International. 2007, 1(1): 206. |
|
Yang Z., Poon R.T.P., Liu Y., Lau C.K., Ho D.W.Y., Tam K.H., Lam C.T. and Fan S.T., High doses of tyrosine kinase inhibitor PTK787 enhance the efficacy of ischemic hypoxia for the treatment of hepatocellular carcinoma: dual effects on cancer cell and angiogenesis, Molecular Cancer Therapeutics. 2006, 5(9): 2261-2270. |
|
Researcher
: Lo CM |
|
Project Title: |
Post-operative adjuvant therapy with recombinant interferon-[alpha] following curative resection of hepatocellular carcinoma: a randomised dose-response controlled trial |
|
Investigator(s): |
Lo CM, |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
02/1999 |
|
Abstract: |
|
To assess the efficacy and safety of interferon [alpha]-2b in reducing the incidence of recurrence after resection of hepatocellular carcinoma. |
|
Project Title: |
Development of anti-HBsAb in patients with chronic hepatitis B after liver transplantation using lamivudine prophylaxis: the possible role of adoptive immunity |
|
Investigator(s): |
Lo CM |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
01/2000 |
|
Abstract: |
|
To investigate effects of donor immune status on the development of anti-HBsAb in patients with chronic hepatitis B after liver transplantation. |
|
Project Title: |
Hepatitis B virus-specific immune response after liver transplantation for chronic hepatitis B using lamivudine prophylaxis |
|
Investigator(s): |
Lo CM, Fan ST, Lau G |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
10/2002 |
|
Abstract: |
|
The project attempts to prospectively study the serial changes in HBV-specific immune response after liver transplantation for chronic hepatitis B. This HBV-specific immune response will be correlated with the donor's HBV immune status to clarify the possibility of adoptive immunity transfer through the liver graft. |
|
Project Title: |
Occult Hepatitis B Virus Reinfection In Liver Transplant Recipient |
|
Investigator(s): |
Lo CM, Lau G |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
09/2006 |
|
Abstract: |
|
Hepatitis B virus (HBV) infection affects
more than 350 million people worldwide(1). In |
|
Project Title: |
The impact of acute phase liver graft injury on tumor recurrence after liver transplantation in patients with hepatocellular carcinoma |
|
Investigator(s): |
Lo CM, Man K, Fan ST |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2007 |
|
Abstract: |
|
To study the significance of early phase liver graft injury related to graft size on late phase tumor recurrence and metastasis after liver transplantation for hepatocellular carcinoma; to investigate the underlying molecular mechanisms. |
|
List of Research Outputs |
|
Chan A., Poon R.T.P., Mh K.C., Chan S.C., Yuen W.K., Yeung C., Lo C.M. and Fan S.T., Effect of changing paradigm for management of hepatocellular carcinoma on the long-term survival of patients with hepatocellular carcinoma (Abstract), The 1st Biennial Congress of the Asian-Pacific Hepato-Pancreato-Biliary Association, Fukuoka, Japan, 20 - 23 March 2007. |
|
Chan A.C.Y., Lo C.M., Ng K.K.C., Chan S.C. and Fan S.T., Implications for management of Mycobacterium tuberculosis infection in adult-to-adult live donor liver transplantation, Liver International. 2007, 27(1): 81-85. |
|
Chan A.C.Y., Lo C.M., Ng I.O.L. and Fan S.T., Liver transplantation for combined hepatocellular cholangiocarcinoma, Asian Journal of Surgery. 2007, 30(2): 143-146. |
|
Chan S.C., Chik B., Liu C.L., Lo C.M. and Fan S.T., A decade of right liver adult-to-adult live donor liver transplantation: mid-term outcomes (Abstract), The International Liver Transplantation Society 13th Annual International Congress, Rio de Janeiro, Brazil, 20 - 23 June 2007. |
|
Chan S.C., Liu C.L., Lo C.M., Lam B.K.Y., Lee E.W.M. and Fan S.T., Donor quality of life before and after adult-to-adult right liver live donor liver transplantation, Liver Transplantation. 2006, 12(10): 1529-1536. |
|
Chan S.C., Fan S.T., Lo C.M. and Liu C.L., Effect of side and size of graft on surgical outcomes of adult-to-adult live donor liver transplantation, Liver Transplantation. 2007, 13(1): 91-98. |
|
Chan S.C., Fan S.T., Lo C.M., Liu C.L. and Wong J., Toward current standards of donor right hepatectomy for adult-to-adult live donor liver transplantation through the experience of 200 cases, Annals of Surgery. 2007, 245(1): 110-117. |
|
Chan S.C., Fan S.T., Liu C.L., Lo C.M., Lam B.K.Y. and Lee E.W.M., Working up donors for high-urgency and elective adult-to-adult live donor liver transplantation, Liver Transplantation. 2007, 13(4): 509-515. |
|
Cheng Q., Man K., Ng T.P., Lo C.M., Poon R.T.P. and Fan S.T., The significance of hepatic stellate cell activation on small-for-size fatty liver graft injury (Abstract), The International Liver Transplantation Society 13th Annual International Congress, Rio de Janeiro, Brazil, 20 - 23 June 2007. |
|
Cheung S.T., Fan S.T., Lee Y.T., Ng I.O.L. and Lo C.M., Biomarker in relation to post-transplant recurrence in liver cancer patients (Abstract), The 2nd Nanjing-Hong Kong Liver Transplantation Symposium, Nanjing, China, 25 - 27 August 2006. |
|
Chik B.H., Liu C.L., Fan S.T., Lo C.M., Poon R.T.P., Lam C.M. and Wong J., Tumor size and operative risks of extended right-sided hepatic resection for hepatocellular carcinoma: implication for preoperative portal vein embolization, Archives of Surgery. 2007, 142(1): 63-69. |
|
Fan
S.T., Lo C.M. and Liu C.L., Major hepatic resection for
primary and metastatic tumors, In: Fischer JE, Bland KI, Callery MP, LoGerfo
FW, Clagett GP, Seeger JM & Jones DB (eds), Mastery of Surgery, 5th
Edition. |
|
Hui C.K., Cheung W.W.W., Chan S.C., Lo C.M. and Lau G., Hepatitis B vaccination and preemptive treatment of hepatitis B virus in liver transplantation, Current Opinion in Organ Transplantation. 2006, 11(6): 594-598. |
|
Hui C.K., Lau E., Monto A., Kim M., Luk J.M.C., Poon R.T.P., Leung N., Lo C.M., Fan S.T., Lau G. and Wright T.L., Natural history of patients with recurrent chronic hepatitis C virus and occult hepatitis B co-infection after liver transplantation, American Journal of Transplantation. 2006, 6(7): 1600-1608. |
|
Kenison J.R., Adam R., Lo C.M. and Trotter J.F., Nineteen donor deaths following living donor liver transplantation: review of the worldwide experience (Abstract), American Journal of Transplantation. 2006, 6: 116-146. |
|
Kenison J.R., Adam R., Lo C.M. and Trotter J.F., Nineteen donor deaths following living donor liver transplantation: review of the worldwide experience (Abstract), Transplantation. 2006, 82: 116. |
|
Lai L., Hui C.K., Poon R.T.P., Shek T.W.H., Lai S.T., Lai J.Y., Lo C.M., Fan S.T., Leung N. and Lau G., The use of transient elastography as a preoperative assessment of hepatic resection (Abstract), The 17th Asian Pacific Association for the Study of the Liver Conference, Kyoto, Japan, 27 - 30 March 2007. Hepatology International. 2007, 1(1): 51. |
|
Lam S.P., Luk J.M.C. and Lo C.M., Potential use of adult bone marrow stromal cells (BMSCS) treatment in an acute liver failure model induced by D-Galactosamine injection (Abstract), Journal of Hepatology. 2006, 44: S54-S54. |
|
Lam S.P., Lau C.K., Cheung C.K.Y., Man K., Luk J.M.C. and Lo C.M., Potential use of mesenchymal stem cells (MSCs) treatment in D-Galactosamine induced acute liver failure model, American Jouarnal of Transplantation. 2007, 7: 323-323. |
|
Lee K.W., Man K., Poon R.T.P., Lo C.M., Yuen P.W., Ng I.O.L., Ng T.P., Leonard W. and Fan S.T., Signal transducers and activators of transcription 5b activation enhances hepatocellular carcinoma aggressiveness through induction of epithelial-mesenchymal transition, Cancer Research. 2006, 66(20): 9948-9956. |
|
Lee T.K., Man K., Poon R.T.P., Lo C.M., Yuen P.W., Ng I.O., Ng K.T., Leonard W. and Fan S.T., Cancer Res., Signal transducers and activators of transcription 5b activation enhances hepatocellular carcinoma aggressiveness through induction of epithelial-mesenchymal transition. 2006, 66: 9948-56. |
|
Liu C.L., Fan S.T., Cheung S.T., Lo C.M., Ng I.O.L. and Wong J., Anterior approach versus conventional approach right hepatic resection for large hepatocellular carcinoma: a prospective randomized controlled study, Annals of Surgery. 2006, 244(2): 194-203. |
|
Liu C.L., Fan S.T., Lo C.M., Tso W.K., Lam C.M. and Wong J., Improved operative and survival outcomes of surgical treatment for hilar cholangiocarcinoma, British Journal of Surgery. 2006, 93(12): 1488-1494. |
|
Lo C.M., Liu C.L., Chan S.C., Lam C.M., Poon R.T.P., Ng I.O.L., Fan S.T. and Wong J., A randomized, controlled trial of postoperative adjuvant interferon therapy after resection of hepatocellular carcinoma, Annals of Surgery. 2007, 245(6): 831-842. |
|
Lo
C.M., Associate Director (1994 - present), Liver
Transplant Centre, |
|
Lo C.M., Associate Editor (2001 - present), Digestive Surgery. 2007. |
|
Lo C.M., Associate Editor (2005 - present), World Journal of Surgery. 2007. |
|
Lo C.M., Associate Editor (2006 - present), American Journal of Transplantation. 2006. |
|
Lo C.M., Associate Editor (2007 - present), 中華消化外科雜誌, 2007. |
|
Lo C.M., Associate Editor (2007 - present), Liver Transplantation. 2007. |
|
Lo C.M., Council Member (1997 - present), Hong Kong Society of Transplantation. 2007. |
|
Lo C.M., Council Member (2005 - present), The College of Surgeons of Hong Kong. 2007. |
|
Lo C.M., Council Member (July 2005 - present), International Liver Transplantation Society. 2007. |
|
Lo C.M., Lau G., Chan S.C., Fan S.T. and Wong J., Efficacy of a pre-S containing vaccine in patients receiving lamivudine prophylaxis after liver transplantation for chronic hepatitis B, American Journal of Transplantation. 2007, 7(2): 434-439. |
|
Lo C.M., Examiner in Licentiate Examination, the Licentiate Committee (1995 - present), Medical Council of Hong Kong. 2007. |
|
Lo C.M., Executive Committee Member (1998 - present), International Society for Digestive Surgery. 2007. |
|
Lo
C.M., Guest Professor (2002 - present), The
|
|
Lo
C.M., Guest Professor (2004 - present), Army
|
|
Lo
C.M., Honorary Consultant (1998 - present), |
|
Lo
C.M., Honorary Consultant (2002 - present), King
Faisal Hospital & Research Centre, |
|
Lo
C.M., Honorary Consultant (2005 - present), Hong
Kong Sanatorium and Hospital, |
|
Lo
C.M., Honorary Senior Consultant (2002 -
present), |
|
Lo
C.M., Issues and management on metastatic
liver disease (Invited Lecture), The 62nd Annual Clinical Congress of
Philippine |
|
Lo
C.M., Lessons from countries where there is
no or little deceased donor transplantation (Invited Lecture), The
International Liver Transplantation Society 2007 Consensus Conference, |
|
Lo
C.M., Liver transplantation for
hepatocellular carcinoma (Invited Lecture), The 23rd National
Gastroenterology Congress, |
|
Lo
C.M., Living donor liver transplantation:
progresses and challenges (State-of-the-Art Lecture), The 20th World
Congress of Internaional Society for Digestive Surgery, |
|
Lo C.M., Fan S.T., Liu C.L., Chan S.C., Ng I.O.L. and Wong J., Living donor versus deceased donor liver transplantation for early unresectable hepatocellular carcinoma, British Journal of Surgery. 2007, 94(1): 78-86. |
|
Lo
C.M., Long-term outcome of adult-to-adult
living donor liver transplantation (Invited Lecture), The Transplantation
Society New Key Opinion Leader Meeting 2006, |
|
Lo
C.M., Management of hepatocellular carcinoma:
can it be evidence-based? (Invited Lecture), The 62nd Annual Clinical
Congress of Philippine |
|
Lo C.M., Member of Editorial Board (2002 - present), Hepatobiliary and Pancreatic Diseases International. 2007. |
|
Lo C.M., Member of Editorial Board (2002 - present), Surgery. 2007. |
|
Lo C.M., Member of Editorial Board (2006 - present), Annals of Surgery. 2007. |
|
Lo C.M., Member of Editorial Board (2007 - 2009), World Journal of Gastroenterology. 2007. |
|
Lo C.M., Member of Editorial Board (2007 - present), 中華普通外科雜誌, 2007. |
|
Lo C.M., Member of Scientific Committee (1998 - present), Cheng Si Yuan China-International Hepatitis Research Foundation . 2007. |
|
Lo C.M., Member, Board of Examiners (2002 - present), The College of Surgeons of Hong Kong. 2007. |
|
Lo
C.M., Member, Committee of |
|
Lo C.M., Member, Exemptions Sub-Committee, the Licentiate Committee (2003 - present), Medical Council of Hong Kong. 2007. |
|
Lo C.M., Member, Panel of Assessors (2004 - present), Medical Council of Hong Kong. 2007. |
|
Lo C.M., National Delegate (1998 - present), International Society for Digestive Surgery. 2007. |
|
Lo C.M., National Editor (2005 - present), Hepato-Gastroenterology. 2007. |
|
Lo C.M., Nonalcoholic steatohepatitis in donors for living donor liver transplantation (Editorial), Transplantation. 2007, 83(3): 265-266. |
|
Lo
C.M., Outcome of liver donor (Invited
Lecture), The 3rd International Symposium on Living Donor Organ
Transplantation, |
|
Lo C.M., President (2004 - 2006), International Society for Digestive Surgery. 2007. |
|
Lo C.M., Prevention of recurrent hepatitis B after liver transplantation (Invited Lecture), The 23rd National Gastroenterology Congress, Istanbul, Turkey, 4 - 7 November 2006. 2006. |
|
Lo
C.M., Prevention of recurrent hepatitis B
after liver transplantation (Invited Lecture), The Third |
|
Lo C.M., Program Committee Member (1997 - present), International Society for Digestive Surgery. 2007. |
|
Lo C.M., Program Committee Member (2006 - present), International Liver Transplantation Society. 2006. |
|
Lo C.M., Radiology pilotage in living donor liver transplantation (Invited Lecture), The 11th Asian Oceanian Congress of Radiolody, Hong Kong, 6 - 9 August 2006. 2006. |
|
Lo
C.M., Recurrent HCC post-liver transplant
(Invited Lecture), The Asian Pacific Digestive Week 2006, |
|
Lo C.M., Reviewer, UICC Fellowship Selection Committee (1997 - present), Internaional Union Against Cancer. 2007. |
|
Lo C.M., Reviewer, American Journal of Transplantation. 2007. |
|
Lo C.M., Reviewer, Annals of Surgery. 2007. |
|
Lo
C.M., Reviewer, Annals of the |
|
Lo C.M., Reviewer, Asian Journal of Surgery. 2007. |
|
Lo C.M., Reviewer, British Journal of Surgery. 2007. |
|
Lo C.M., Reviewer, Endoscopy. 2007. |
|
Lo C.M., Reviewer, Hepatology. 2007. |
|
Lo C.M., Reviewer, Hong Kong Medical Journal. 2007. |
|
Lo C.M., Reviewer, Liver Transplantation. 2007. |
|
Lo C.M., Reviewer, Surgery. 2007. |
|
Lo C.M., Small-for-size syndrome and impact on outcome of liver transplantation (Invited Lecture), The Transplantation Society New Key Opinion Leader Meeting 2007, Hong Kong, 18 - 21 January 2007. 2007. |
|
Lo C.M., Steering Committee Member (2002 - present), Asian Pacific Digestive Week. 2007. |
|
Lo C.M., Surgical aspect in hepatocellular carcinoma (Invited Lecture), Scientific Seminar - An Update on the Management of Hepatocellular Carcinoma of Hong Kong College of Radiologists, Hong Kong, 17 March 2007. 2007. |
|
Lo C.M., Technical aspects: evidence supporting once controversial issues (Invited Lecture), The International Liver Transplantation Society 13th Annual International Congress, Rio de Janeiro, Brazil, 20 - 23 June 2007. 2007. |
|
Lo C.M., The ECD live liver donor (Invited Lecture), The American Society of Transplant Surgeons 7th Annual State-of-the-Art Winter Symposium, Florida, USA, 12 - 14 January 2007. 2007. |
|
Lo C.M., Vice President (Internal Affairs) (2007 - present), The College of Surgeons of Hong Kong. 2007. |
|
Luo Y., Lo C.M., Cheung C.K.Y., Lau G., Fan S.T. and Wong J., Identification of hepatitis B virus-specific lymphocytes in human liver grafts from HBV-immune donors, Liver Transplantation. 2007, 13(1): 71-79. |
|
Man K., Xiao J., Ng T.P., Cheng Q., Sun B., Wang Y., Sun K.W., Poon R.T.P. and Lo C.M., Adiponectin as a novel therapy for the suppression of the liver cancer growth and metastasis (Paper Presentation), the 14th European Organisation for the Research and Treatment of Cancer, National Cancer Institute, and American Association for Cancer Research (EORTC-NCI-AARC) Symposium on Molecular Targets and Cancer Therapeutics, Prague, Czech Republic, 7 - 10 November 2006. European Journal of Cancer Supplement. 2006, 50. |
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Man K., Xiao J., Ng T.P., Cheng Q., Sun K.W., Lo C.M., Poon R.T.P. and Fan S.T., Combination therapy for liver tumor growth and metastasis by low dose rapamycin and FTY720 (Paper Presentation), the 14th European Organisation for the Research and Treatment of Cancer, National Cancer Institute, and American Association for Cancer Research (EORTC-NCI-AARC) Symposium on Molecular Targets and Cancer Therapeutics, Prague, Czech Republic, 7 - 10 November 2006. |
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Man K., Ng T.P., Xu A.M., Cheng Q., Sun B., Sun K.W., Lee K.W., Lo C.M., Poon R.T.P. and Fan S.T., Fat-derived hormone adiponectin suppresses liver tumor growth and metastases (Paper Presentation), The 98th Annual Meeting of the American Association for Cancer Research, Los Angeles, USA, 14 - 18 April 2007. |
|
Man K., Lo C.M., Ng T.P., Sun S., Sun K.W. and Fan S.T., Significant correlation between intragraft gene expression profiles linking to acute phase injury and angoneness with HCC recurrence after LDLT (Plenary Lecture), The International Liver Transplantation Society 13th Annual International Congress, Rio de Janeiro, Brazil, 20 - 23 June 2007. 2007. |
|
Man K., Lo C.M., Xiao J., Ng T.P., Sun K.W., Wang Y. and Fan S.T., The significance of acute phase graft injury on tumor recurrence/metastases in live donor liver transplantation (Abstract), World Transplant Congress 2006, Boston, U.S.A., 22 -27 July 2006. |
|
Man K., Lo C.M., Xiao J., Ng T.P., Sun K.W., Wang Y. and Fan S.T., The significance of graft size on tumor recurrence after liver transplantation - activation of cell invasion pathway (Abstract), World Transplant Congress 2006, Boston, U.S.A., 22 - 27 July 2006. |
|
Ng K.K.C., Poon R.T.P., Lo C.M., Yuen J.H.F., Tso W.K. and Fan S.T., Analysis of recurrence pattern and its influence on survival outcome after radiofrequency ablation of hepatocellular carcinoma (Grassi Prize Finalist Presentation), The 20th World Congress of the International Society for Digestive Surgery 2006, Rome, Italy, 29 November - 2 December 2006. 2006. |
|
Ng K.K.C., Poon R.T.P., Lo C.M., Yuen J.H.F., Tso W.K. and Fan S.T., Analysis of recurrence pattern and survival outcome after radiofrequency ablation of hepatocellular carcinoma: a single institution experience (Abstract), Surgical Practice. 2006, 10: A1. |
|
Ng K.K.C., Poon R.T.P., Lo C.M. and Fan S.T., Comparison of laparoscopic and open hepatectomy for small hepatocellular carcinoma (Oral Presentation), The 20th World Congress of the International Society for Digestive Surgery 2006, Rome, Italy, 29 November - 2 December 2006. 2006. |
|
Ng K.K.C., Poon R.T.P., Lo C.M. and Fan S.T., Comparison of laparoscopic and open hepatectomy for small hepatocellular carcinoma (Oral Presentation), The Congress of Endoscopic and Laparoscopic Surgeons of Asia 2006, Seoul, Korea, 18 - 21 October 2006. 2006. |
|
Ng
T.P., Man K., Sun K.W., Lee K.W., Poon R.T.P., Lo C.M. and Fan S.T., Clinicopathological
significance of homeoprotein Six |
|
Ng
T.P., Man K., Ho J.W.Y., Sun K.W., Lee K.W., Zhao Y., Lo C.M., Poon R.T.P. and Fan S.T., Marked suppression of tumor
growth by FTY |
|
Ng T.P., Man K., Cheng Q., Sun B., Lee K.W., Poon R.T.P., Lo C.M. and Fan S.T., Suppression of tumorigenesis and metastasis of hepatocellular of hepatocellular carcinoma by shRNA interference targeting on inhibition of homeoprotein Six1 (Paper Presentation), The 98th Annual Meeting of the American Association for Cancer Research, Los Angeles, USA, 14 - 18 April 2007. |
|
Poon R.T.P., Fan S.T., Lo C.M., Liu C.L. and Wong J., Difference in tumor invasiveness in cirrhotic patients with hepatocellular carcinoma fulfilling the Milan criteria treated by resection and transplantation: impact on long-term survival, Annals of Surgery. 2007, 245(1): 51-58. |
|
Poon R.T.P., Fan S.T., Lo C.M., Ng K.K.C., Yuen W.K., Yeung C. and Wong J., External drainage of pancreatic duct with a stent to reduce leakage rate of pancreaticojejunostomy after pancreaticoduodenectomy: a prospective randomized trial (Abstract), Annual Meeting of American Surgical Association, Colorado Springs, USA, 26 - 28 April 2007. |
|
Shih K.C., Man K., Ng T.P., Xiao J., Fan S.T. and Lo C.M., Distinct gene signatures linked to acute phase injury and tumor invasiveness in tumor development after liver transplantation using small-for-size grafts (Abstract), The International Liver Transplantation Society 13th Annual International Congress, Rio de Janeiro, Brazil, 20 - 23 June 2007. |
|
Shih K.C., Man K., Ng T.P., Xiao J., Fan S.T. and Lo C.M., Rising Star Award - "Distinct gene signatures linked to acute phase injury and tumor invasiveness in tumor development after liver transplantation using small-for-size grafts", The International Liver Transplantation Society 13th Annual International Congress, Rio de Janeiro, Brazil, 20 - 23 June 2007. 2007. |
|
Trotter J.F., Adam R., Lo C.M. and Kenison J., Documented deaths of hepatic lobe donors for living donor liver transplantation, Liver Transplantation. 2006, 12(10): 1485-1488. |
|
Zhang H., Hui C.K., Lee P.Y., Chan W., Yueng Y.H., Leung K.W., Lu L., Leung N., Lo C.M., Fan S.T., Luk J.M.C., Xu A., Lam K.S.L., Kwong Y.L. and Lau G., Serum adiponectin is increased in advancing liver fibrosis and decline with reduction in fibrosis in chronic hepatitis B, The 17th Asian Pacific Association for the Study of the Liver Conference, Kyoto, Japan, 27 - 30 March 2007, Hepatology International. 2007, 242: 7. |
|
Researcher
: Lo CY |
|
Project Title: |
Establishment of a comprehensive service and registry for hereditary familial endocrinopathy syndromes in Hong Kong |
|
Investigator(s): |
Lo CY, Lam KSL |
|
Department: |
Surgery |
|
Source(s) of Funding: |
S.K. Yee Medical Foundation - General Award |
|
Start Date: |
01/2005 |
|
Abstract: |
|
To provide a comprehensive clinical, genetic and counseling services for the diagnosis, management, screening and education of familial endocrinopathy syndromes; to establish a registry on all index patients as well as their family members with familial endocrinopathy syndromes in Hong Kong with respect to detailed information including the type of endocrinopathy sydromes, familial pedigrees, patients' demographics, presentation, surgical treatment, pathology of tumours, genetic changes, outcome and follow-up; to improve the standard of care for patients with familial endocrinopathy syndromes through this program; to educate the public and the medical professions advance and the role of genetics in management of these hereditary conditions; to conduct on-going research on familial endocrine diseases by establishing a tissue and serum bank from patients and relatives with familial endocrinopathy sydromes. |
|
List of Research Outputs |
|
Abraham D., Singh N., Lang B.H.H., Chan W.F. and Lo C.Y., Benign nodular goitre presenting as acute airway obstruction, Australia and New Zealand Journal of Surgery. 2007, 77: 364-367. |
|
Chan W.F., Lang B.H. and Lo C.Y., The role of intraoperative neuromonitoring of recurrent laryngeal nerve during thyroidectomy: a comparative study on 1000 nerves at risk, Surgery. 2006, 140(6): 866-872. |
|
Chan W.F., Lang B.H.H. and Lo C.Y., The role of intraoperative neuromonitoring of recurrent laryngeal nerve during thyroidectomy: a prospective comparative study on 1000 nerves at risk, Surgery. 2006, 140(6): 866-873. |
|
Lam A.K.Y., Lo C.Y., Leung P., Lang B.H.H., Chan W.F. and Luk J.M.C., The clinicopathological
roles of alterations of tumour suppressor gene p |
|
Lang B. and Lo C.Y., Parathyroid cancer, Surgical Oncology Clinics of North American. 2006, 15(3): 573-584. |
|
Lang B., Lo C.Y., Chan W.F., Lam K.Y. and Wan K.Y., Restaging of differentiated thyroid carcinoma by the Sixth Edition AJCC/UICC TNM staging system : Stage migration and predictability, Annals of Surgical Oncology. 2007, 14: 1551-1559. |
|
Lang B.H., Lo C.Y., Chan W.F., Lam K.Y. and Wan K.Y., Staging systems for follicular thyroid carcinoma: application to 171 consecutive patients treated in a tertiary referral centre, Endocrine Related Cancer. 2007, 14(1): 29-42. |
|
Lang B.H., Lo C.Y., Chan W.F., Chan W.F., Lam K.Y. and Wan K.Y., Staging systems for papillary thyroid carcinoma: A review and comparison, Annals of Surgery. 2007, 245: 366-378. |
|
Lang B.H.H., Lo C.Y., Chan W.F., Lam K.Y. and Wan K.Y., Prognostic factors in papillary and follicular thyroid carcinoma: their implications for cancer staging, Annals Surgical Oncology. 2007, 14(2): 730-738. |
|
Lang B.H.H., Lo C.Y., Chan W.F., Lam K.Y. and Wan K.Y., Restaging of differentiated thyroid carcinoma by the 6th edition AJCC/UICC TNM staging system: stage migration and predictability, Annals of Surgical Oncology. 2007, 14(5): 1551-1559. |
|
Lang B.H.H., Lo C.Y., Chan W.F., Lam K.Y. and Wan K.Y., Staging for follicular thyroid carcinoma: application to 171 consecutive patients treated in a tertiary referral center, Endocrine-Related Cancer. 2007, 14(1): 29-42. |
|
Lang B.H.H., Lo C.Y., Chan W.F., Lam K.Y. and Wan K.Y., Staging for papillary thyroid carcinoma: a review and comparison, Annals of Surgery. 2007, 245(3): 366-378. |
|
Lang B.H.H. and Lo C.Y., Surgical options in undifferentiated thyroid carcinoma, World Journal of Surgery. 2007, 31: 969-977. |
|
Lo C.Y., A huge population and economic reforms are pushing the evolution of surgery in the Mainland, Peer-Reviewed Contemporary Surgery. 2007, 63: 61-62. |
|
Lo
C.Y., Lang
H.H.B., Chan W.F., Kung A.W.C.
and Lam K.S.L., A prospective evaluation
of preoperative localization by technetium |
|
Lo C.Y., Invited speaker: Approaches to thyroid nodules and the relevance of radiation exposure, University Health Service, The University of Hong Kong, Hong Kong, 25 July 2006. 2006. |
|
Lo C.Y., Need for an individualized and aggressive management of multinodular goiters of endemic zones by specially trained surgeons: experience in Western Nepal, World Journal of Surgery. 2006, 30: 2110-2111. |
|
Lo C.Y., Recurrence after total thyroidectomy for benign multinodular goiter, World Journal of Surgery. 2007, 31: 599-600. |
|
Lo C.Y., In: Invited speaker: Optimising the outcome of thyroid surgery, Surgical Grand Round in Hong Kong Sanatorium & Hospital, Hong Kong, 7 July 2006. 2006. |
|
Researcher
: Lui ELH |
|
List of Research Outputs |
|
Liu Y., Lei L., Lui E.L.H., Lau C.P.Y., Chen Y., Wo Y.H., Fan S.T. and Poon R.T.P., Tyrosine kinase inhibitor PTK 787/ZK222584 inhibits liver fibrosis (Abstract), The 17th Asian Pacific Association for the Study of the Liver Conference, Kyoto, Japan, 27 - 30 March 2007. Hepatology International. 2007, 1(1): 206. |
|
Researcher
: Lui VCH |
|
Project Title: |
Cre-inducible disruption of Hedgehog signaling in neural crest cell: a novel approach to study roles of Hedgehog in enteric nerous system development |
|
Investigator(s): |
Lui VCH, Tam PKH, Sham MH |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2003 |
|
Abstract: |
|
To generate a DNA construct for Cre-inducible expression of a Ptc1[Delta]loop2 protein; to generate transgenic mice carrying the Ptc1[Delta]loop2 DNA construct by microinjection; transgenic mice will be crossed with a vagal NCC specific Cre mouse strain; to analysis of abnormal phenotypes in the devleoping ENS of the transgenic mutant mice. |
|
Project Title: |
Conditional knockout of Patched gene in enteric neural crest cells: functional study of the role of Hedgehog signaling in enteric nervous system development |
|
Investigator(s): |
Lui VCH, Tam PKH, Sham MH |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
10/2004 |
|
Abstract: |
|
To cross floxed Ptc1 mice with a vagal NCC specific Cre mouse strain (b3-IIIa-cre); to analyze the abnormal phenotypes in the developing ENS of the transgenic mutant mice; to analyze the effects of mesenchyme-derived factors on NCCs of the transgenic mutant mice. |
|
Project Title: |
Investigation of Hoxb5 functions in enteric neurons in late gestation and neonatal period |
|
Investigator(s): |
Lui VCH, Sham MH, Tam PKH |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2004 |
|
Abstract: |
|
To investigate the functions of Homeobox
gene Hoxb |
|
Project Title: |
Functional
analysis of Hoxb |
|
Investigator(s): |
Lui VCH, Sham MH, Tam PKH |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
11/2005 |
|
Abstract: |
|
To analyse the expression pattern of
Hoxb5 protein in enteric neurons in postnatal and adult mice; to induce the
expression of en-hoxb |
|
Project Title: |
Investigation of cell autonomous function of Hedgehog signaling on vagal neural crest cells by conditional knockout of Smoothened in mice |
|
Investigator(s): |
Lui VCH, Ngan ESW, Tam PKH, Sham MH |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2007 |
|
Abstract: |
|
(1) Cross floxed Smo mice with a vagal NCC specific cre mouse strain (b3-IIIa-cre); (2) analyze the abnormal phenotypes in the developing ENs of the transgenic mutant mice; (3) analyze the effects of mesenchyme-derived factors on NCCs of the transgenic mutant mice. |
|
Project Title: |
Investigation of the moleular interactions of HOXB5 and RET gene promoter |
|
Investigator(s): |
Lui VCH, Garcia-Barcelo MM, Tam PKH |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
03/2007 |
|
Abstract: |
|
PURPOSE: To investigate the HOXB5
regulation on the expression of RET receptor tyrosine kinase gene. KEY
ISSUES: The enteric nervous system (ENS) is composed of interconnecting
ganglia of neurons and glia within the gut wall, controlling the intestinal
peristalsis. In mammals, vagal neural crest cells (NCCs) migrate from the
neural tube, enter the foregut and colonize the entire length of the
intestine rostro-caudally, differentiating into neurons and glia(1-5).
Defective ENS development could result in fewer (hypoganglionosis), and/or
absence of enteric ganglia (aganglionosis) affecting the distal intestine as
seen in Hirschsprung’s disease (HSCR). Patients with abnormal ENS develop
intestinal obstruction due to defective intestinal peristalsis. HSCR displays
strong racial variation in the incidence, with the highest frequency among
Asians (2.8 per 10,000 life births)(6). Homeobox (Hox) genes represented the
clustered group of homoebox genes crucial to embryo patterning and cell fate.
In mammals, 39 Hox genes located in 4 chromosomal clusters (A, B, C and D) are
organized in 13 paralogous groups(7). Hox protein functions as
transcriptional activators by binding to target DNA via its homeodomain and
activates target genes transcription. HOXB5 displays a distinct pattern of
expression in mouse and human embryonic gut, suggesting a unique role of HOXB |
|
List of Research Outputs |
|
Chen Y., Li X., Tian L., Lui V.C.H., Dallman M.J., Lamb J.R. and Tam P.K.H., Inhibition of sonic hedgehog signaling reduces chronic rejection and prolongs allograft survival in a rat orthotopic small bowel transplantation model, Transplantation. 2007, 83(10): 1351-1357. |
|
Chen
Y., Kam C.S.K., Lui V.C.H. and Tam P.K.H., TGF-B blockade aggravates
gut ischemia reperfusion injury via activation of resident macrophages, 53rd
Annual International Congress of the British Association of Paediatric
Surgeons, |
|
Garcia-Barcelo M.M., Miao X., Lui V.C.H., So M.T., Ngan E.S.W., Leon T.Y., Lau D.K., Liu T.T., Lao X., Guo W., Holden W.T., Moore J. and Tam P.K.H., Correlation between genetic variations in Hox clusters and Hirschsrpung's disease, Annals of Human Genetics. 2007, 71(Pt 4): 526-536. |
|
Lui V.C.H., Cheng W.C., Leon Y.Y., Lau K.C., Garcia-Barcelo M.M., Miao X., Wall N. and Tam P.K.H., HOXB5 regulates the expression of RET in ENS: a novel Hirschsprung's gene, The 40th Annual Meeting of the Pacific Association of Paediatric Surgeons together with the Annual Scientific Meeting of the Australasian Association of Paediatric Surgeons, Queenstown, New Zealand, 15-19 April 2007. |
|
Miao X., Garcia-Barcelo M.M., So M.T., Leon Y.Y., Lau K.C., Liu T., Chan E.K.W., Lan L.C.L., Wong K.K.Y., Lui V.C.H. and Tam P.K.H., Role of RET and PHOX2B gene polymorphisms in risk of Hirschsprung's disease in Chinese population, Gut. 2007, 56(5): 736. |
|
Ngan E.S.W., Poon H.C., Sham M.H., Tam P.K.H. and Lui V.C.H., Aberrant KLF4 expression and BMP signaling cause proliferation defect in PTC1-/- neural crest cells (The Best Poster Presentation at the Forum), MGH-HKU-Nature China Forum, Hong Kong, 5-6 March 2007. |
|
Ngan E.S.W., Poon H.C., Sham M.H., Hui C.C., Wainwright B., Tam P.K.H. and Lui V.C.H., Aberrant Kruppel-like factor 4 expression causes proliferation defect in Patched1-/- neural crest cells, The 5th Annual Meeting of the International Society for Stem Cell Research, Cairns, Queensland, Australia, 17-20 June 2007. |
|
Ngan E.S.W., Sit Y.L.F., Lee K.Y., Miao X., Yuan Z., Wang W.L., Nicholls J.M., Wong K.K.Y., Garcia-Barcelo M.M., Lui V.C.H. and Tam P.K.H., Implications of endocrine gland - derived vascular endothelial growth factor/prokineticin-1 signaling in human neuroblastoma progression., Clinical Cancer Research. 2007, 13(3): 868-875. |
|
Ngan E.S.W., Lee K.Y., Sit Y.L.F., Poon H.C., Chan J.K.Y., Sham M.H., Lui V.C.H. and Tam P.K.H., Prokineticin-1 modulates proliferation and differentiation of enteric neural crest cells, Biochimica et Biophysica Acta. 2007, 1773(4): 536-545. |
|
Ngan
E.S.W., Garcia-Barcelo M.M., Lui V.C.H. and Tam P.K.H., Prokineticins in Neural
Crest Cell Growth and Associated Disorders, |
|
Ngan
E.S.W., Lee K.Y., Sit F.Y.L., Chan J.K.Y., Sham M.H., Lui V.C.H. and Tam P.K.H., Roles of Prokineticin |
|
Ngan E.S.W., Lui V.C.H., Garcia-Barcelo M.M. and Tam P.K.H., Signaling mechanisms regulating neural crest cells in growth & tumorigenesis [Invited Lecture - Ngan ESW], Stem Cell Workshop: Strategic Research Theme of Development and Reproduction, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, 2-3 November 2006. |
|
Ngan E.S.W., Lui V.C.H., Garcia-Barcelo M.M. and Tam P.K.H., Signaling mechanisms regulating neural crest cells: in growth and tumorigenesis (Invited Lecture), Signalling mechanisms regulating neural crest cells: in growth and tumorigenesis, Stem Cell Workshop , SRT of Development and Reproduction, Hong Kong, 2 - 3 November 2006. 2006. |
|
Ngan E.S.W., Poon H.C., Sham M.H., Hui C.C., Brandon W., Tam P.K.H. and Lui V.C.H., The Best Poster Presentation, MGH-HKU-Nature China Forum . 2007. |
|
Researcher
: Lui WM |
|
List of Research Outputs |
|
Lee R., Lui W.M., Cheung R.T.F., Leung G.K.K. and Chan K.H., Mechanical thrombectomy in acute proximal middle cerebral artery thrombosis with the Alligator Retrieval Device, Cerebrovascular Diseases. 2007, 23: 69-71. |
|
Researcher
: Luk JMC |
|
Project Title: |
Prevention of endotoxin-mediated liver injury by recombinant integrin subunit (RIS), Anti-CD18 Fv and TW-PS22 |
|
Investigator(s): |
Luk JMC, Fan ST |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
09/2002 |
|
Abstract: |
|
The project attempts to exploit new approaches for preventing endotoxin-mediated liver injury in experimental sepsis and ischemia/reperfusion (I/R) animal models. |
|
Project Title: |
Target delivery of glyrrhetinic acid to hepatic stellate cells in liver injury |
|
Investigator(s): |
Luk JMC, Zhang QS |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2004 |
|
Completion Date: |
07/2006 |
|
Abstract: |
|
To synthesize M6P26-HSA conjugated with GA as a carrier for HSC; to determine the organ distribution of the GA and its localization at HSCs in situ and in vitro; to evaluate the anti-fribotic activities of the neoglycoconjugate GA in HSC. |
|
Project Title: |
Investigating Liver Intestine-Cadherin Function In Hepatocellular Carcinoma |
|
Investigator(s): |
Luk JMC, Lee PY, Ng IOL, Fan ST |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
12/2005 |
|
Abstract: |
|
Purpose: - The purpose of this study is to investigate the functions and pathogenic roles of a novel cadherin, CDH17, recently identified in HCC, which is found to be a potential disease marker and correlated with poor prognosis. Key issues: - Cadherins are a superfamily of Ca2+-dependent cell adhesion molecules, which are important in mediating adherent junction formation and maintaining tissue integrity. LI-cadherin (CDH17) is involved in the embryonic development of liver and gastrointestinal tract, and functions as an intestinal peptide transporter. However, CDH17 is not detectable in normal adult liver. Our earlier observations, however, have shown that over-expression of LI-cadherin is found in over 80% of HCC, but not in non-cancerous tissues or normal liver tissues from these patients. Moreover, our group has identified an alternative splicing form with exon 7 skipped in the LI-cadherin gene among 50% of the HCC tumors. Expression of the LI-cadherin splice variant in HCC is significantly associated with venous infiltration and early intra-hepatic recurrence of tumor as well as shorter overall survival of HCC patients. Because of its high prevalence and association with poor clinical outcomes, LI-cadherin is suggested to be a potential disease marker for HCC. More interestingly, we did not observe the splice variant in over 100 gastric adenocarcinoma specimens that were tested, indicating that the splice variant is HCC specific. Problems to be addressed: - The functions of the LI-cadherin wild-type form or exon 7-skipped splice variant in HCC remain unknown. Will over-expression of LI-cadherin affect classical E-cadherin expression and function? Does the splice variant have a dominant-negative function to cause cell-cell disintegration, thereby promoting tumorigenesis and cancer metastasis? Our future goal is to establish a mouse model to determine what will happen if CDH17 is forcibly expressed in postnatal and adult liver, when transcription of the gene is normally repressed or silenced in these stages? To address these issues, there is a need to obtain specific antibodies that could differentiate the wild type and splicing forms of LI-cadherin, since the current commercial antibodies failed to detect the exon 7-spliced variant in HCC. The proposed study will also investigate the expression pattern and biological functions of LI-cadherin molecule in HCC using both in vitro culture and xenograft mouse models, to confirm our hypothesis of its pathogenic roles in mediating tumor invasiveness and enhancing the metastatic potentials. Specific Aims: 1. To generate and characterize monoclonal antibodies that could differentiate wild-type and exon 7-spliced form of LI-cadherin molecules; 2. To study and correlate the expression patterns of LI-cadherin and E-cadherin/catenin complexes in HCC specimens of different clinical stages and features; 3. To establish stable transfectants expressing wild-type and splice variants of LI-cadherin, and examine the tumorigenic properties in experimental invasion and intra-hepatic metastasis animal models; 4. To design and characterize anti-sense oligonucleotides to block LI-cadherin function in high metastatic HCC cell lines. |
|
Project Title: |
Proteomics of Hepatocellular Carcinoma: Biomarkers discovery and validation |
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Investigator(s): |
Luk JMC |
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Department: |
Surgery |
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Source(s) of Funding: |
Seed Funding Programme for Basic Research |
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Start Date: |
03/2007 |
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Abstract: |
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In recent years, our group has employed gene expression profiling and proteome analysis to investigate cancer signatures and differential biomarkers/patterns in predicting disease outcomes and treatment responses. The primary objective is to establish a panel of biomarkers for early detection and better prognosis of hepatocellular carcinoma (HCC). Also this would allow us to identify new therapeutic targets for HCC treatments. To date, an array of proteins markers (stress-response heat shock protein markers, specifically HSP27, HSP70 and glucose-regulated protein 78, mortalin-2, cadherin-17) has been identified in association with HCC development, and many show promises to become useful in medical practice. However, a large gap still exists between the ability to discover potential biomarkers and the ability to assess the real value of these genes/proteins in cancer diagnosis. Therefore, it is prudent to validate these promising biomarkers for their intended use. Objectives:1. To research on the development and validation of promising early cancer biomarkers for risk prediction and early detection of HCC. 2. To develop molecular assays for multicenter studies of biomarkers performance on HCC diagnosis3. To characterize and evaluate key therapeutic targets discovered via the proteomic profiling analysis of HCC malignancy |
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List of Research Outputs |
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Chan
V.W.M., Luk J.M.C. and Fan S.T., LI-cadherin
(CDH17)/beta-catenin pathway is involved in tumor proliferation and
metastatic potentials of hepatocellular carcinoma, Hepatology. 2006,
44(4): |
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Cheung C.M., Tang J.C.O., Lee P.Y., Hu L., Guan X.Y., Srivastava G., Wong J., Luk J.M.C. and Law S.Y.K., Establishment and characterization of a new xenograft-derived human esophageal squamous cell carcinoma cell line HKESC-4 of chinese origin, 11th Research Postgraduate Symposium (11th RPS), The University of Hong Kong Li Ka Shing Faculty of Medicine, Hong Kong, 7 December. 2006. |
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Chung M.F., Lam A.K.Y., Luk J.M.C., Law S.Y.K., Chan K.W., Lee P.Y. and Wong J., Clinical significance of e-cadherin and p120 catenin expression and localization in esophageal squamous cell carcinoma, 11th Research Postgraduate Symposium (11th RPS), The University of Hong Kong Li Ka Shing Faculty of Medicine, Hong Kong, 7 December. 2006. |
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Hui C.K., Bowden S., Zhang H.Y., Wong A., Lewin S., Rousseau F., Mommeja-Marin H., Lee N.P., Luk J.M.C., Locarnini S., Leung N., Naoumov N.V. and Lau G., Comparison of real-time PCR assays for monitoring serum hepatitis B virus DNA levels during antiviral therapy, Journal of Clinical Microbiology. 2006, 44(8): 2983-2987. |
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Hui C.K., Lau E., Monto A., Kim M., Luk J.M.C., Poon R.T.P., Leung N., Lo C.M., Fan S.T., Lau G. and Wright T.L., Natural history of patients with recurrent chronic hepatitis C virus and occult hepatitis B co-infection after liver transplantation, American Journal of Transplantation. 2006, 6(7): 1600-1608. |
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Hui
C.K., Zhang H., Lee P.Y., Marin H., Yueng Y.H., Leung K.W., Lu L., Leung N., Luk J.M.C., Naoumov N., Huang F. and Lau G., Role of regulatory T cells in
natural immunity and sustained pharmacological control hepatitis B infection,
The Liver Meeting of The American Association for the Study of Liver, Hepatology.
2006, 44: |
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Hui
C.K., Zhang H.Y., Lee P.Y.,
Mommeja-Marin H., Yueng Y.H., Leung K.W., Lu L., Leung N., Luk J.M.C., Naoumov N.N., Huang F.P.
and Lau G., Role of regulatory T
cells in natural immunity and sustained pharmacological control of chronic
hepatitis B infection, Hepatology. 2006, 44(4): |
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Hwang I.S.S., Tang F., Leung P.L., Li Y.Y., Fan S.T. and Luk J.M.C., The gene expression of adrenomedullin, calcitonin-receptor-like receptor and receptor activity modifying proteins (RAMPs) in CCl(4)-induced rat liver cirrhosis, Regulatory Peptides. 2006, 135(1-2): 69-77. |
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Konrad M., Schaller A., Seelow D., Pandey A.V., Waldegger S., Lesslauer A., Vitzthum H., Suzuki Y., Luk J.M.C., Becker C., Schlingmann K.P., Schmid M., Rodriguez-Soriano J., Ariceta G., Cano F., Enriquez R., Juppner H., Bakkaloglu S.A., Hediger M.A., Gallati S., Neuhauss S.C., Nurnberg P. and Weber S., Mutations in the tight-junction gene claudin 19 (CLDN19) are associated with renal magnesium wasting, renal failure, and severe ocular involvement, American Journal of Human Genetics. 2006, 79: 949 - 957. |
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Lam A.K.Y., Lo C.Y., Leung P., Lang B.H.H., Chan W.F. and Luk J.M.C., The clinicopathological
roles of alterations of tumour suppressor gene p |
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Lam S.P., Luk J.M.C. and Lo C.M., Potential use of adult bone marrow stromal cells (BMSCS) treatment in an acute liver failure model induced by D-Galactosamine injection (Abstract), Journal of Hepatology. 2006, 44: S54-S54. |
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Lam S.P., Lau C.K., Cheung C.K.Y., Man K., Luk J.M.C. and Lo C.M., Potential use of mesenchymal stem cells (MSCs) treatment in D-Galactosamine induced acute liver failure model, American Jouarnal of Transplantation. 2007, 7: 323-323. |
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Lau G., Zhu R., Lei T., Ng M.Y., Luk J.M.C., Sham P., Chiu J.F. and He Q.Y., Identification of biomarkers for the prediction of HBV related HCC by integrated proteomics (Abstract), The 17th Asian Pacific Association for the Study of the Liver Conference, Kyoto, Japan, 27 - 30 March 2007. |
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Lau G., Zhu R., Lei T., Ng M.Y., Luk J.M.C., Sham P., Chiu J.F. and He Q.Y., Identification of biomarkers for the prediction of HBV related HCC by integrated proteomics, Hepatology International. 2007, 1(1): 75. |
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Lee P.Y., Leung K.W., Wo J.Y., Tam P.C., Yeung W.S.B. and Luk J.M.C., Blockage of testicular connexins induced apoptosis in rat seminiferous spithelium, Apoptosis. 2006, 11: 1215-1229. |
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Lee P.Y., Yeung W.S.B. and Luk J.M.C., Junction interaction in the seminiferous epithelium: regulatory roles of connexin-based gap junction, Frontiers In Bioscience. 2007, 12: 1552-1562. |
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Lee P.Y., Cheung N., Lam B.Y.H., Sham P., Lau G., Fan S.T., Luk J.M.C. and Luk J.M.C., Proteomics of mouse liver from embryo to adult: a lesion for HCC (Abstract), The 17th Asian Pacific Association for the Study of the Liver Conference, Kyoto, Japan, 27 - 30 March 2007. Hepatology International. 2007, 1(1): 21. |
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Lu
L., Sun R.W.Y., Hui C.K., Chen R., Luk J.M.C., Che C.M. and Lau K.K., In Vitro Anti-hepatitis B
Virus Activities and Mechanism of Metal-based Nanoparticles , Hepatology .
2006, 44 (Suppl.1): |
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Lu L., Sun R.W.Y., Hui C.K., Chen R., Luk J.M.C., Che C.M. and Lau G., In Vitro Anti-hepatitis B Virus Activities and Mechanism of Silver Nanoparticles,The 17th Asian Pacific Association for the Study of the Liver Conference, Kyoto, Japan, 27 - 30 March 2007, Hepatology International. 2007, 242: 14. |
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Lu L., Sun R.W.Y., Hui C.K., Chen R., Luk J.M.C., Che C.M. and Lau G., Size-dependent anti-hepatic B virus activities and mechanism of silver nanoparticles, The 17th Asian Pacific Association for the Study of the Liver Conference, Kyoto, Japan, 27 - 30 March 2007. |
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Lu L., Sun R.W.Y., Hui C.K., Chen R., Luk J.M.C., Che C.M. and Lau G., Size-dependent anti-hepatitis B virus activities and mechanism of silver nanoparticles (Abstract), Hepatology International. 2007, 1(1): 14. |
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Luk J.M.C., (Invited Lecture) Cadherin-17 signaling in liver cancer, The Croucher Advanced Study Institute on "Molecular Genetics and Cell Signaling in Cancer and Cancer Metastasis, Hong Kong, 29 January - 2 February 2007. 2007. |
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Luk J.M.C., (Invited Lecture) Cadherins in tumorigenicity and metastasis of hepatocellular carcinoma , Faculty of Medicine & Immunology Program, National University of Singapore, Singapore, 10 November 2006. 2006. |
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Luk J.M.C., (Invited Lecture) Cancer biomarkers for Hepatocellular Carcinoma - from discovery to validation, Merck-Rosetta Inpharmatics, Seattle, Washington, U.S.A., 1 November 2006. 2006. |
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Luk J.M.C., (Invited Lecture) Heat shock proteins in liver cancer , KRIBB Workshop on Biomarkers Discovery for Liver Cancer, Deajeon, Korea, 18 - 19 September 2006. 2006. |
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Luk J.M.C., (Invited Lecture) Heat shock proteins in liver cancer: a proteomic quest, 4th Annual Conference of Chinese HUPO, Xian, China, 22 - 23 August 2006. 2006. |
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Luk J.M.C., (Invited Lecture) Oncoproteomics of hepatocellular carcinoma , Nanjing Medical University, Drum Tower Hospital, Nanjing, China, 25 August 2006. 2006. |
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Luk J.M.C., (Invited Lecture) Oncoproteomics of hepatocellular carcinoma , Nanjing Medical University, Drums Tower Hospital, China, 25 August 2006. 2006. |
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Luk J.M.C., (Invited lecture) Discovery of cancer biomarkers for hepatocellular carcinoma - the promise and the pitfall, Centre for Integrated Genomic Medical Research, University of Manchester, United Kingdom, 20 - 21 November 2006. 2006. |
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Luk J.M.C., (Invited lecture) Heat shock proteins in liver cancer, KRIBB Workshop on Biomarkers Discovery for Liver Cancer, Deajeon, Korea, 18 - 19 September 2006. 2006. |
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Luk J.M.C., (Invited lecture) New genomic and proteomic markers of hepatocellular carcinoma, Joint National Cancer Institute and The Hepatitis B Foundation Meeting on Early Cancer Detection Network Meeting, Princeton, NJ, U.S.A., 25 - 26 October 2006. 2006. |
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Luk J.M.C., (Keynote Lecture) An integrative approach to biomarkers discovery and validateio for hepatocellular carcinoma , International Conference on hepatocellular carcinoma management & proteomics updates, 30th Anniversary of the Chang Gung Memorial Hospital, Tao-Yuan, Taiwan, 2 December 2006. 2006. |
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Luk J.M.C., (Plenary Lecture) Toward the biomarker identification for prediction of HBV-related HCC by integrated proteomics, APASL Meeting, Kyoto International Conference & Convention Center, Kyoto, Japan, 27- 30 March 2007. 2007. |
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Luk J.M.C., Lee P.Y., Shum K.Y., Siu A.F.M., Che C.M., Tam P.C., Cheung A.N.Y., Yang Z.M., Lin Y.N., Matzuk M.M., Lee C.K.F. and Yeung W.S.B., Acrosome-Specific Gene AEP1: Identification, Characterization and Roles in Spermatogenesis , Journal of Cellular Physiology . 2006, 209: 755-766. |
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Luk J.M.C. and Poon R.T.P., Blue Sky Project - Molecular Profiling of Hepatocellular Carcinoma, HKU-Rosetta Inpharmatics LLC Agreement. 2007, LK46307. |
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Luk
J.M.C., Chan
V.W.M. and Fan S.T., Cadherin |
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Luk J.M.C., Chairman - From laboratory to bedside, Hong Kong Surgical Forum, Hong Kong, 12 - 13 January 2007. 2007. |
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Luk J.M.C., Evaluation of WinUBoost safety and efficacy in normal liver and hepatic fibrosis model (Invited Lecture), 5th Meeting of Consortium for Globalization of Chinese Medicine cum International Forum on Chinese Medicine, Zhuhai, China, 21 - 22 September 2006. |
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Luk J.M.C., Executive Chairman and Member of Organizing and Scientific Committee, International Proteomics Symposium and AOHUPO Microsomal Proteomic Initiatives Workshop and The 5th Annual Congress and satellite symposium of Chinese HUPO, Guangzhou-Hong Kong, China, 20 - 25 August 2007. 2007. |
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Luk J.M.C., Executive Council Member (From 2007 - present), CNHUPO (China). 2007. |
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Luk J.M.C., Founding and Council Member (From 2006 - present), The Hong Kong Proteomics Society. 2007. |
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Luk J.M.C., Heat shock proteins in liver cancer (Invited Lecture), 4th Annual Conference of Chinese HUPO, Xian, China, 22 - 23 August 2006. 2006. |
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Luk J.M.C., Zhang Q.S., Lee P.Y., Wo Y.H., Leung P.L., Liu L.X., Hu M.Y., Cheung K.F., Hui C.K., Lau G. and Fan S.T., Hepatic stellate cell-targeted delivery of M6P-HSA-glycyrrhetinic acid attenuates hepatic fibrogenesis in a bile duct ligation rat model, Liver International. 2007, 27(4): 548-557. |
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Luk J.M.C., Hong Kong Team Coordinator (From 2005 - present), Liver Cancer Biomarkers Group of ICBDC. 2007. |
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Luk J.M.C., Internal examiner, Ph.D. thesis (TO Kar-Wing), Dendritic cells as cancer vaccine, Dept of Pathology, University of Hong Kong, April 16, 2007. 2007. |
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Luk J.M.C., Intraportal transplantation of bone marrow stromal cells restores liver functions in hepatic injury models, 2nd Nanjing-Hong Kong Liver Transplant Meeting, Nanjing, China, 26 - 27 August 2006. |
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Luk J.M.C., Member (From 2004 - present), The Science Advisory Board. 2007. |
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Luk J.M.C., Member (From 2006 - present), the Consortium for Globalization of Chinese Medicine. 2007. |
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Luk J.M.C., Member, Editorial Advisory Board (From 2006 - present), Scientific Journals International. 2007. |
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Luk J.M.C., Member, Editorial Advisory Board, The Open Transplantation Journal. 2007. |
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Luk J.M.C., Member, Organizing Commitee, The Croucher Advanced Study Institute (ASI), "Molecular Genetics and Cell Signaling in Cancer and Cancer Metastasis:, 29 January - 2 February 2007. 2007. |
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Luk J.M.C., Member, Steering Committee (From 2005 - present), International Cancer Biomarkers Discovery Consortium. 2007. |
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Luk J.M.C., Mitochondria Heat Shock protein 75 (mthsp75) is a predictive marker for Early Tumor Recurrence in Hepatocellular carcinoma, The 13rd Hong Kong International Cancer Congress, Hong Kong, 15 - 17 November 2006. |
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Luk
J.M.C., Yi
X. and Fan S.T., Mitochondrial
heat shock protein 75 9MTHSP75) is a predictive marker for early tumor
recurrence in hepatocellular carcinoma (Abstract), Hepatology. 2006,
44(4): |
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Luk
J.M.C., Mortalin (HSP |
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Luk J.M.C., Yi X., Lee P.Y., Guan X.Y., Lau G. and Fan S.T., Mortalin-2 is an accurate prognostic biomarker for early recurrence of liver carcinoma (Abstract), The 17th Asian Pacific Association for the Study of the Liver Conference, Kyoto, Japan, 27 - 30 March 2007. Hepatology International. 2007, 1(1): 68. |
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Luk J.M.C., New genomic and proteomic markers of hepatocellular carcinoma (Invited Lecture), Joint National Cancer Institute (NCI) and The Hepatitis B Foundation (HBF) meeting on Early Cancer Detection Network Meeting, Princeton, U.S.A., 25 - 26 October 2006. |
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Luk J.M.C., New geonomic and proteomic markers of hepatocellular carcinoma (Invited Lecture), Joint National Cancer Institute (NCI) and The Hepatitis B Foundation (HBF) meeting on Early Cancer Detection Network Meeting, Princeton, U.S.A., 25 - 26 October 2006. |
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Luk J.M.C., Proteomics of mouse liver from embryo to adult: a lesso for HCC (Invited Lecture), APASL Meeting, Kyoto, Japan, 27 - 30 March 2007. |
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Luk J.M.C., Reviewer (2006 - present), Theriogenology. 2007. |
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Luk J.M.C., Reviewer (2007-2008), Journal of Proteome Research. 2007. |
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Luk J.M.C., Reviewer (2007-2008), Liver International. 2007. |
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Luk J.M.C., Reviewer (From 1997 - present), Journal of Immunology. 2007. |
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Luk J.M.C., Reviewer (From 2003 - present), Asian Journal of Surgery. 2007. |
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Luk J.M.C., Reviewer (From 2004 - present), Analytical Biochemistry. 2007. |
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Luk J.M.C., Reviewer (From 2004 - present), Journal of Biomedical Science. 2007. |
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Luk J.M.C., Reviewer (From 2004 - present), Journal of Gastroenterology & Hepatology. 2007. |
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Luk J.M.C., Reviewer (From 2004 - present), Journal of Hepatology. 2007. |
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Luk J.M.C., Reviewer (From 2005 - present), Cancer Investigation. 2007. |
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Luk J.M.C., Reviewer (From 2005 - present), Oncogene. 2007. |
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Luk J.M.C., Reviewer (From 2006 - present), Acta Pharmacologica Sinica. 2007. |
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Luk J.M.C., Reviewer (From 2006 - present), Clinica Chimica Acta. 2007. |
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Luk J.M.C., Reviewer (From 2006 - present), International Journal of Cancer Research. 2007. |
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Luk J.M.C., Reviewer (From 2006 - present), Journal of Clinical Endocrinology and Metabolism. 2007. |
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Luk J.M.C., Reviewer (From 2006 - present), Journal of Surgical Oncology. 2007. |
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Luk J.M.C., Reviewer (From 2006 - present), Molecular Medicine. 2007. |
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Luk J.M.C., Reviewer (From 2006 - present), Stem Cells and Development. 2007. |
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Luk J.M.C., Reviewer (From 2006 - present), Transplantation. 2007. |
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Luk J.M.C., Reviewer (From 2006 - present), World Journal of Surgery. 2007. |
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Luk J.M.C., Reviewer, American Journal of Physiology. 2007. |
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Luk J.M.C., Reviewer, Journal of Clinical Endocrinology and Metabolism. 2006. |
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Luk J.M.C., Reviewer, Journal of Gastroenterology & Hepatology. 2006. |
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Luk J.M.C., Reviewer, Proteomics. 2007. |
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Luk J.M.C., Reviewer, Transplantation. 2006. |
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Tam Y.T., Zuo Y., Luk J.M.C., Yeung W.S.B. and Lee C.K.F., Spatiotemporal expression of a novel acrosome expressing protein 2 (AEP2/VAD1.2) in spermatogenesis. , XIX North American Testis Workshop; "Chromosome Structure and Gene Expression", Tampa, FL, U.S.A., 18 - 21 April 2007. |
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Wang X., Luk J.M.C., Garcia-Barcelo M.M., Miao X., Leung P.L., Ho D.W.Y., Cheung S.T., Lam B.Y.H., Cheung C.K.Y., Wong S.Y., Lau S.S.M., So M.T., Yu W.C., Cai Q., Liu K.S.Y., Hui C.K., Lau G., Poon R.T.P., Wong J. and Fan S.T., Liver intestine-cadherin (CDH17) haplotype is associated with increased risk of hepatocellular carcinoma, Clinical Cancer Research. 2006, 12(17): 5248-5252. |
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Zhang H., Hui C.K., Lee P.Y., Chan W., Yueng Y.H., Leung K.W., Lu L., Leung N., Lo C.M., Fan S.T., Luk J.M.C., Xu A., Lam K.S.L., Kwong Y.L. and Lau G., Serum adiponectin is increased in advancing liver fibrosis and decline with reduction in fibrosis in chronic hepatitis B, The 17th Asian Pacific Association for the Study of the Liver Conference, Kyoto, Japan, 27 - 30 March 2007, Hepatology International. 2007, 242: 7. |
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Zhang Q.S. and Luk J.M.C., Plasma proteomic pattern predicts the stages of rat liver fibrosis, Zhonghua Gan Zang Bing Za Zhi. 2006, 14(9): 695-697. |
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Zhu R., Lei T., Ng M., Luk J.M.C., Sham P., Chiu J.F. and Lau G., Identification of biomakers for the prediction of hepatitis B related hepatocellular carcinoma by integrated proteomics, The 17th Asian Pacific Association for the Study of the Liver Conference, Kyoto, Japan, 27 - 30 March 2007, Hepatology International. 2007, 242: 75. |
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Researcher
: Luo Y |
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List of Research Outputs |
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Luo Y., Hepatitis B virus-specific immune response after liver transplantation for chronic hepatitis B, Thesis, Doctor of Philosophy thesis. 2006. |
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Luo Y., Lo C.M., Cheung C.K.Y., Lau G., Fan S.T. and Wong J., Identification of hepatitis B virus-specific lymphocytes in human liver grafts from HBV-immune donors, Liver Transplantation. 2007, 13(1): 71-79. |
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Researcher
: Man K |
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Project Title: |
The significance of graft size on tumor recurrence after liver transplantation |
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Investigator(s): |
Man K, Fan ST, Lo CM |
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Department: |
Surgery |
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Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
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Start Date: |
09/2004 |
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Abstract: |
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To test the hypothesis that small-for-size grafts are more susceptible to tumor recurrence after liver transplantation in a rat liver transplantation model; to clarify the mechanism of tumor recurrence. |
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Project Title: |
The effect of Rapamycin on ischemia/reperfusion injury in liver transplantation using small-for-size grafts in a cirrhotic rat model - the investigation of the hepatic stellate cell activation and ROCK pathway |
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Investigator(s): |
Man K, Lo CM, Fan ST |
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Department: |
Surgery |
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Source(s) of Funding: |
Seed Funding Programme for Basic Research |
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Start Date: |
01/2005 |
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Completion Date: |
12/2006 |
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Abstract: |
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To explore the protective effect of an immunosuppressive drug Rapamycin on ischemia/reperfusion in jury in a rat liver transplantation model using small-for-size grafts and cirrhotic recipients by investigation of the activation of hepatic stellate cells and ROCK pathway. |
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Project Title: |
Fat-derived hormone adiponectin as a novel therapy for fatty liver graft injury |
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Investigator(s): |
Man K, Xu A, |
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Department: |
Surgery |
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Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
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Start Date: |
09/2005 |
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Abstract: |
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To investigate the protective effect of adiponectin on fatty live-graft in a rat-liver transplant model. |
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Project Title: |
The signifcance of hepatic ischemia/reperfuison injury of small liver remnant on liver tumor growth and metastasis |
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Investigator(s): |
Man K, Lo CM |
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Department: |
Surgery |
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Source(s) of Funding: |
Seed Funding Programme for Basic Research |
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Start Date: |
03/2006 |
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Abstract: |
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Background (key issue and problems being
addressed)The surgical stress including hepatic ischemia-reperfusion injury
during liver resection promoting liver metastasis has been reported. The
activation of local cytokines after partial hepatectomy also accelerated
liver tumor growth and promoted distant metastasis. However, previous studies
only described the phenomenon without precise investigation of the mechanism.
Up to now, there has been no study investigating the impact of hepatic
ischemia-reperfusion injury and major hepatectomy on the activation of tumor
cell invasion and migration pathways. Small GTPases of the |
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List of Research Outputs |
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Cheng Q., Man K., Ng T.P., Lo C.M., Poon R.T.P. and Fan S.T., The significance of hepatic stellate cell activation on small-for-size fatty liver graft injury (Abstract), The International Liver Transplantation Society 13th Annual International Congress, Rio de Janeiro, Brazil, 20 - 23 June 2007. |
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Lam S.P., Lau C.K., Cheung C.K.Y., Man K., Luk J.M.C. and Lo C.M., Potential use of mesenchymal stem cells (MSCs) treatment in D-Galactosamine induced acute liver failure model, American Jouarnal of Transplantation. 2007, 7: 323-323. |
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Lee K.W., Poon R.T.P., Yuen P.W., Man K., Yang Z., Guan X.Y. and Fan S.T., Rac activation is associated with hepatocellular carcinoma metastasis by up-regulation of vascular endothelial growth factor expression, Clinical Cancer Research. 2006, 12(17): 5082-5089. |
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Lee K.W., Poon R.T.P., Yuen P.W., Ling M.T., Wang X., Wong Y.C., Guan X.Y., Man K., Tang Z.Y. and Fan S.T., Regulation of angiogenesis by Id-1 through hypoxia-inducible factor-1 mediated vascular endothelial growth factor up-regulation in hepatocellular carcinoma, Clinical Cancer Research. 2006, 12(23): 6910-6919. |
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Lee K.W., Man K., Poon R.T.P., Lo C.M., Yuen P.W., Ng I.O.L., Ng T.P., Leonard W. and Fan S.T., Signal transducers and activators of transcription 5b activation enhances hepatocellular carcinoma aggressiveness through induction of epithelial-mesenchymal transition, Cancer Research. 2006, 66(20): 9948-9956. |
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Lee K.W., Poon R.T.P., Yuen P.W., Ling M.T., Kwok W.K., Wang X., Wong Y.C., Guan X.Y., Man K., Chau K.L. and Fan S.T., Twist overexpression correlates with hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition, Clinical Cancer Research. 2006, 12(18): 5369-5376. |
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Lee T.K., Man K., Poon R.T.P., Lo C.M., Yuen P.W., Ng I.O., Ng K.T., Leonard W. and Fan S.T., Cancer Res., Signal transducers and activators of transcription 5b activation enhances hepatocellular carcinoma aggressiveness through induction of epithelial-mesenchymal transition. 2006, 66: 9948-56. |
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Lee T.K., Poon R.T.P., Yuen P.W., Ling M.T., Kwok W.K., Wang X.H., Wong Y.C., Guan X.Y., Man K., Chau K.L. and Fan S.T., Clin Cancer Res., Twist overexpression correlates with hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition. 2006, 12: 5369-76. |
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Lee T.K., Poon R.T.P., Yuen P.W., Man K., Yang Z., Guan X.Y. and Fan S.T., Clin Cancer Res, Rac activation is associated with hepatocellular carcinoma metastasis by up-regulation of vascular endothelial growth factor expression. 2006, 12: 5082-9. |
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Lee T.K., Poon R.T.P., Yuen P.W., Ling M.T., Wang X.H., Wong Y.C., Guan X.Y., Man K., Tang Z.Y. and Fan S.T., Clin Cancer Res, Regulation of angiogenesis by Id-1 through hypoxia-inducible factor-1alpha-mediated vascular endothelial growth factor up-regulation in hepatocellular carcinoma. 2006, 12: 6910-9. |
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Man K., Xiao J., Ng T.P., Cheng Q., Sun B., Wang Y., Sun K.W., Poon R.T.P. and Lo C.M., Adiponectin as a novel therapy for the suppression of the liver cancer growth and metastasis (Paper Presentation), the 14th European Organisation for the Research and Treatment of Cancer, National Cancer Institute, and American Association for Cancer Research (EORTC-NCI-AARC) Symposium on Molecular Targets and Cancer Therapeutics, Prague, Czech Republic, 7 - 10 November 2006. European Journal of Cancer Supplement. 2006, 50. |
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Man K., Xiao J., Ng T.P., Cheng Q., Sun K.W., Lo C.M., Poon R.T.P. and Fan S.T., Combination therapy for liver tumor growth and metastasis by low dose rapamycin and FTY720 (Paper Presentation), the 14th European Organisation for the Research and Treatment of Cancer, National Cancer Institute, and American Association for Cancer Research (EORTC-NCI-AARC) Symposium on Molecular Targets and Cancer Therapeutics, Prague, Czech Republic, 7 - 10 November 2006. |
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Man K., Editorial Board, Reviewer, Liver Transplantation. 2007. |
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Man K., Ng T.P., Xu A.M., Cheng Q., Sun B., Sun K.W., Lee K.W., Lo C.M., Poon R.T.P. and Fan S.T., Fat-derived hormone adiponectin suppresses liver tumor growth and metastases (Paper Presentation), The 98th Annual Meeting of the American Association for Cancer Research, Los Angeles, USA, 14 - 18 April 2007. |
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Man K., Reviewer, Acta Pharmacologica Sincia. 2007. |
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Man K., Reviewer, British Journal of Cancer. 2007. |
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Man K., Reviewer, British Journal of Surgery. 2007. |
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Man K., Reviewer, European Journal of Cancer. 2007. |
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Man K., Reviewer, Gut. 2007. |
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Man K., Reviewer, Hepatology. 2007. |
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Man K., Reviewer, Journal of Gastroenterology and Hepatology. 2007. |
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Man K., Reviewer, Liver. 2007. |
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Man K., Reviewer, Liver International. 2007. |
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Man K., Reviewer, Surgery. 2007. |
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Man K., Reviewer, Transplant Immunology. 2007. |
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Man K., Reviewer, Transplantation. 2007. |
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Man K., Reviewer, World Journal of Surgery. 2007. |
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Man K., Lo C.M., Ng T.P., Sun S., Sun K.W. and Fan S.T., Significant correlation between intragraft gene expression profiles linking to acute phase injury and angoneness with HCC recurrence after LDLT (Plenary Lecture), The International Liver Transplantation Society 13th Annual International Congress, Rio de Janeiro, Brazil, 20 - 23 June 2007. 2007. |
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Man
K., Small-for-size syndrome and impact on
outcome of liver transplantation (Invited Lecture), The Transplantation
Society New Key Opinion Leader Meeting 2007, |
|
Man
K., The impact of acute phase graft injury on
late phase tumor recurrence (Invited Lecture), Liver Transplantation
Forum, |
|
Man K., Lo C.M., Xiao J., Ng T.P., Sun K.W., Wang Y. and Fan S.T., The significance of acute phase graft injury on tumor recurrence/metastases in live donor liver transplantation (Abstract), World Transplant Congress 2006, Boston, U.S.A., 22 -27 July 2006. |
|
Man
K., The significance of acute phase liver
graft injury on late phase tumour recurrence (Invited Lecture), Hong Kong
Surgical Forum, |
|
Man K., Lo C.M., Xiao J., Ng T.P., Sun K.W., Wang Y. and Fan S.T., The significance of graft size on tumor recurrence after liver transplantation - activation of cell invasion pathway (Abstract), World Transplant Congress 2006, Boston, U.S.A., 22 - 27 July 2006. |
|
Ng
T.P., Man K., Sun K.W., Lee K.W., Poon R.T.P., Lo C.M. and Fan S.T., Clinicopathological
significance of homeoprotein Six |
|
Ng
T.P., Man K., Ho J.W.Y., Sun K.W., Lee K.W., Zhao Y., Lo C.M., Poon R.T.P. and Fan S.T., Marked suppression of tumor
growth by FTY |
|
Ng T.P., Man K., Cheng Q., Sun B., Lee K.W., Poon R.T.P., Lo C.M. and Fan S.T., Suppression of tumorigenesis and metastasis of hepatocellular of hepatocellular carcinoma by shRNA interference targeting on inhibition of homeoprotein Six1 (Paper Presentation), The 98th Annual Meeting of the American Association for Cancer Research, Los Angeles, USA, 14 - 18 April 2007. |
|
Pang R.W.C., Lee K.W., Man K., Poon R.T.P., Fan S.T., Kwong Y.L. and Tse E.W.C., PIN1 expression contributes to hepatic carcinogenesis, Journal of Pathology. 2006, 210(1): 19-25. |
|
Shih K.C., Man K., Ng T.P., Xiao J., Fan S.T. and Lo C.M., Distinct gene signatures linked to acute phase injury and tumor invasiveness in tumor development after liver transplantation using small-for-size grafts (Abstract), The International Liver Transplantation Society 13th Annual International Congress, Rio de Janeiro, Brazil, 20 - 23 June 2007. |
|
Shih K.C., Man K., Ng T.P., Xiao J., Fan S.T. and Lo C.M., Rising Star Award - "Distinct gene signatures linked to acute phase injury and tumor invasiveness in tumor development after liver transplantation using small-for-size grafts", The International Liver Transplantation Society 13th Annual International Congress, Rio de Janeiro, Brazil, 20 - 23 June 2007. 2007. |
|
Sun
K.W., Man K., Liu C.L., Poon R.T.P. and Fan S.T., The significance of Pyk |
|
Researcher
: Miao X |
|
List of Research Outputs |
|
Garcia-Barcelo M.M., King S.K., Miao X., So M.T., Holden W.T., Moore J.H., Sutcliffe J.R., Hutson J.M. and Tam P.K.H., Application of HapMap data to the evaluation of 8 candidate genes for pediatric slow transit constipation, Journal of Pediatric Surgery. 2007, 42(4): 666-671. |
|
Garcia-Barcelo M.M., Miao X., Lui V.C.H., So M.T., Ngan E.S.W., Leon T.Y., Lau D.K., Liu T.T., Lao X., Guo W., Holden W.T., Moore J. and Tam P.K.H., Correlation between genetic variations in Hox clusters and Hirschsrpung's disease, Annals of Human Genetics. 2007, 71(Pt 4): 526-536. |
|
Garcia-Barcelo M.M., Amiel J., Antinolo G., Borrego S., Burzynski G., Ceccherini I., Emison E., Eng C., Fernandez R., Griseri P., Hofstra R., Kashuk C., Lantien F., Lyonnet S., Miao X., Tam P.K.H., Tullio-Pelet A., West K. and Chakravarti A., Higher prevalence of Hirschsprung disease in China explained by a common RET mutation, 56th Annual Meeting of the American Society of Human Genetics, New Orleans, U.S.A., 9-13 October 2006. |
|
Lui V.C.H., Cheng W.C., Leon Y.Y., Lau K.C., Garcia-Barcelo M.M., Miao X., Wall N. and Tam P.K.H., HOXB5 regulates the expression of RET in ENS: a novel Hirschsprung's gene, The 40th Annual Meeting of the Pacific Association of Paediatric Surgeons together with the Annual Scientific Meeting of the Australasian Association of Paediatric Surgeons, Queenstown, New Zealand, 15-19 April 2007. |
|
Miao X., Zhang X., Zhang L., Guo Y., Hao B., Tan W., He F. and Lin D., Adenosine diphosphage ribosyl transferase and x-ray repair cross-complementing 1 polymorphisms in gastric cardia cancer, Gastroenterology. 2006, 131(2): 420-427. |
|
Miao X., Garcia-Barcelo M.M., So M.T., Leon Y.Y., Lau K.C., Liu T., Chan E.K.W., Lan L.C.L., Wong K.K.Y., Lui V.C.H. and Tam P.K.H., Role of RET and PHOX2B gene polymorphisms in risk of Hirschsprung's disease in Chinese population, Gut. 2007, 56(5): 736. |
|
Ngan E.S.W., Sit Y.L.F., Lee K.Y., Miao X., Yuan Z., Wang W.L., Nicholls J.M., Wong K.K.Y., Garcia-Barcelo M.M., Lui V.C.H. and Tam P.K.H., Implications of endocrine gland - derived vascular endothelial growth factor/prokineticin-1 signaling in human neuroblastoma progression., Clinical Cancer Research. 2007, 13(3): 868-875. |
|
Wang X., Luk J.M.C., Garcia-Barcelo M.M., Miao X., Leung P.L., Ho D.W.Y., Cheung S.T., Lam B.Y.H., Cheung C.K.Y., Wong S.Y., Lau S.S.M., So M.T., Yu W.C., Cai Q., Liu K.S.Y., Hui C.K., Lau G., Poon R.T.P., Wong J. and Fan S.T., Liver intestine-cadherin (CDH17) haplotype is associated with increased risk of hepatocellular carcinoma, Clinical Cancer Research. 2006, 12(17): 5248-5252. |
|
Wang X., Miao X., Cai Q., Garcia-Barcelo M.M. and Fan S.T., SMYD3 tandem repeats polymorphism is not associated with the occurrence and metastasis of hepatocellular carcinoma in a Chinese population, Experimental Oncology. 2007, 29(1): 71-73. |
|
Researcher
: Ng KB |
|
List of Research Outputs |
|
Leung
G.K.K., Ng K.B., Ng J.K.F. and Hung K.N., Best Oral Poster
Presentation. Title: 'Initial experience with the PFA-100® analyzer in
neurosurgical patients taking aspirin.', Annual Scientific Meeting2006,
Hong Kong Neurosurgical Society, |
|
Leung S.C.M., Leung G.K.K., Ng K.B. and Hung K.N., Surgery for Brain Metastasis: the Queen Mary Hospital Experience , Annual Scientific Meeting 2006, Hong Kong Neurosurgical Society, Hong Kong, 8 - 9 December 2006. |
|
Researcher
: Ng KKC |
|
List of Research Outputs |
|
Chan A.C.Y., Lo C.M., Ng K.K.C., Chan S.C. and Fan S.T., Implications for management of Mycobacterium tuberculosis infection in adult-to-adult live donor liver transplantation, Liver International. 2007, 27(1): 81-85. |
|
Chok K.S.H., Ng K.K.C., Poon R.T.P., Lam C.M., Yuen J.H.F., Tso W.K. and Fan S.T., Comparable survival in patients with unresectable hepatocellular carcinoma treated by radiofrequency ablation or transarterial chemoembolization, Archives of Surgery. 2006, 141(12): 1231-1236. |
|
Chow D.H.F., Sinn L.H.Y., Ng K.K.C., Lam C.M., Yuen J.H.F., Fan S.T. and Poon R.T.P., Radiofrequency ablation for hepatocellular carcinoma and metastatic liver tumors: a comprative study, Journal of Surgical Oncology. 2006, 94(7): 565-571. |
|
Mulier S., Ni Y., Frich L., Burdio F., Denys A.L., De Wispelaere J.F., Dupas B., Habib N., Hoey M., Jansen M.C., Lacrosse M., Leveillee R., Miao Y., Mulier P., Mutter D., Ng K.K.C., Santambrogio R., Stippel D., Tamaki K., van Gulik T.M., Marchal G. and Michel L., Experimental and clinical radiofrequency ablation: proposal for standardized description of coagulation size and geometry, Annals of Surgical Oncology. 2007, 14(4): 1381-1396. |
|
Ng K.K.C., Poon R.T.P., Lo C.M., Yuen J.H.F., Tso W.K. and Fan S.T., Analysis of recurrence pattern and its influence on survival outcome after radiofrequency ablation of hepatocellular carcinoma (Grassi Prize Finalist Presentation), The 20th World Congress of the International Society for Digestive Surgery 2006, Rome, Italy, 29 November - 2 December 2006. 2006. |
|
Ng K.K.C., Poon R.T.P., Lo C.M., Yuen J.H.F., Tso W.K. and Fan S.T., Analysis of recurrence pattern and survival outcome after radiofrequency ablation of hepatocellular carcinoma: a single institution experience (Abstract), Surgical Practice. 2006, 10: A1. |
|
Ng
K.K.C., Associate Consultant, |
|
Ng K.K.C., Poon R.T.P., Lo C.M. and Fan S.T., Comparison of laparoscopic and open hepatectomy for small hepatocellular carcinoma (Oral Presentation), The 20th World Congress of the International Society for Digestive Surgery 2006, Rome, Italy, 29 November - 2 December 2006. 2006. |
|
Ng K.K.C., Poon R.T.P., Lo C.M. and Fan S.T., Comparison of laparoscopic and open hepatectomy for small hepatocellular carcinoma (Oral Presentation), The Congress of Endoscopic and Laparoscopic Surgeons of Asia 2006, Seoul, Korea, 18 - 21 October 2006. 2006. |
|
Ng
K.K.C., Current results of surgical resection
for liver metastasis (Invited Lecture), The 13th Hong Kong International
Cancer Congress 2006, |
|
Ng
K.K.C., Innovative use of RF energy in
minimally invasive surgery. The application in liver surgery (Invited
Lecture), The Royal College of Surgeons of Edinburgh and The College of
Surgeons of Hong Kong Conjoint Scientific Congress |
|
Ng K.K.C., Intraoperative radiofrequency ablation for malignant liver tumors (Invited Lecture), Macau International Forum 2007 Hepatobiliary and Pancreatic Surgery, Macau, 13 - 16 April 2007. 2007. |
|
Ng K.K.C., Reviewer, Annals of Surgery. 2007. |
|
Ng K.K.C., Reviewer, Asian Journal of Surgery. 2007. |
|
Ng K.K.C., Reviewer, British Journal of Radiology. 2007. |
|
Ng K.K.C., Reviewer, Cancer. 2007. |
|
Ng K.K.C., Reviewer, Cytokine. 2007. |
|
Ng K.K.C., Reviewer, Digestive Diseases and Sciences. 2007. |
|
Ng K.K.C., Reviewer, European Journal of Surgical Oncology. 2007. |
|
Ng K.K.C., Reviewer, European Surgical Research. 2007. |
|
Ng K.K.C., Reviewer, Hepatobiliary and Pancreatic Diseases International. 2007. |
|
Ng
K.K.C., Reviewer, |
|
Ng K.K.C., Reviewer, Journal of Gastroenterology and Hepatology. 2007. |
|
Ng K.K.C., Reviewer, Journal of Surgical Research. 2007. |
|
Ng K.K.C., Reviewer, Liver International. 2007. |
|
Ng K.K.C., Reviewer, Surgical Laparoscopy, Endoscopy and Percutaneous Techniques. 2007. |
|
Ng
K.K.C., Reviewer, Surgical Practice of the
|
|
Ng K.K.C., Reviewer, Urology. 2007. |
|
Ng K.K.C., Reviewer, World Journal of Surgery. 2007. |
|
Ng
K.K.C., Selection for resection in chronic
liver disease: Eastern perspective (Invited Lecture), The 5th
International Meeting Hepatocellular Carcinoma: Eastern and Western
experiences 2007, |
|
Ng K.K.C., Tumor spread to cystic duct as a novel prognostic indicator for gallbladder carcinoma, World Journal of Surgery. 2007, 31(1): 162-163. |
|
Ng
K.K.C., Tutor, The Intercollegiate Basic
Surgical Skills Course 2006, The |
|
Poon R.T.P., Ng K.K.C., Tso W.K., Woo R., Pang R.W.C., Tai K.S. and Fan S.T., A phase I/II trial of transarterial chemoembolization for hepatocellular carcinoma using a novel intrarterial drug eluting beads (Abstract), The 5th International Hepatocellular Carcinoma Meeting: Eastern and Western Experiences, Houston, USA, 11 - 13 January 2007. |
|
Poon R.T.P., Fan S.T., Lo C.M., Ng K.K.C., Yuen W.K., Yeung C. and Wong J., External drainage of pancreatic duct with a stent to reduce leakage rate of pancreaticojejunostomy after pancreaticoduodenectomy: a prospective randomized trial (Abstract), Annual Meeting of American Surgical Association, Colorado Springs, USA, 26 - 28 April 2007. |
|
Poon R.T.P., Lau C.P.Y., Pang R.W.C., Ng K.K.C., Yuen J.H.F. and Fan S.T., High serum vascular endothelial growth factor levels predict poor prognosis after radiofrequency ablation of hepatocellular carcinoma: importance of tumor biomarker in ablative therapies, Annals of Surgical Oncology. 2007, 14(6): 1835-1845. |
|
Researcher
: Ng TP |
|
List of Research Outputs |
|
Cheng Q., Man K., Ng T.P., Lo C.M., Poon R.T.P. and Fan S.T., The significance of hepatic stellate cell activation on small-for-size fatty liver graft injury (Abstract), The International Liver Transplantation Society 13th Annual International Congress, Rio de Janeiro, Brazil, 20 - 23 June 2007. |
|
Lee K.W., Man K., Poon R.T.P., Lo C.M., Yuen P.W., Ng I.O.L., Ng T.P., Leonard W. and Fan S.T., Signal transducers and activators of transcription 5b activation enhances hepatocellular carcinoma aggressiveness through induction of epithelial-mesenchymal transition, Cancer Research. 2006, 66(20): 9948-9956. |
|
Man K., Xiao J., Ng T.P., Cheng Q., Sun B., Wang Y., Sun K.W., Poon R.T.P. and Lo C.M., Adiponectin as a novel therapy for the suppression of the liver cancer growth and metastasis (Paper Presentation), the 14th European Organisation for the Research and Treatment of Cancer, National Cancer Institute, and American Association for Cancer Research (EORTC-NCI-AARC) Symposium on Molecular Targets and Cancer Therapeutics, Prague, Czech Republic, 7 - 10 November 2006. European Journal of Cancer Supplement. 2006, 50. |
|
Man K., Xiao J., Ng T.P., Cheng Q., Sun K.W., Lo C.M., Poon R.T.P. and Fan S.T., Combination therapy for liver tumor growth and metastasis by low dose rapamycin and FTY720 (Paper Presentation), the 14th European Organisation for the Research and Treatment of Cancer, National Cancer Institute, and American Association for Cancer Research (EORTC-NCI-AARC) Symposium on Molecular Targets and Cancer Therapeutics, Prague, Czech Republic, 7 - 10 November 2006. |
|
Man K., Ng T.P., Xu A.M., Cheng Q., Sun B., Sun K.W., Lee K.W., Lo C.M., Poon R.T.P. and Fan S.T., Fat-derived hormone adiponectin suppresses liver tumor growth and metastases (Paper Presentation), The 98th Annual Meeting of the American Association for Cancer Research, Los Angeles, USA, 14 - 18 April 2007. |
|
Man K., Lo C.M., Ng T.P., Sun S., Sun K.W. and Fan S.T., Significant correlation between intragraft gene expression profiles linking to acute phase injury and angoneness with HCC recurrence after LDLT (Plenary Lecture), The International Liver Transplantation Society 13th Annual International Congress, Rio de Janeiro, Brazil, 20 - 23 June 2007. 2007. |
|
Man K., Lo C.M., Xiao J., Ng T.P., Sun K.W., Wang Y. and Fan S.T., The significance of acute phase graft injury on tumor recurrence/metastases in live donor liver transplantation (Abstract), World Transplant Congress 2006, Boston, U.S.A., 22 -27 July 2006. |
|
Man K., Lo C.M., Xiao J., Ng T.P., Sun K.W., Wang Y. and Fan S.T., The significance of graft size on tumor recurrence after liver transplantation - activation of cell invasion pathway (Abstract), World Transplant Congress 2006, Boston, U.S.A., 22 - 27 July 2006. |
|
Ng
T.P., Man
K., Sun K.W., Lee K.W., Poon R.T.P., Lo C.M. and Fan S.T., Clinicopathological
significance of homeoprotein Six |
|
Ng
T.P., Man
K., Ho J.W.Y., Sun K.W., Lee K.W., Zhao Y., Lo C.M., Poon R.T.P. and Fan S.T., Marked suppression of tumor
growth by FTY |
|
Ng T.P., Man K., Cheng Q., Sun B., Lee K.W., Poon R.T.P., Lo C.M. and Fan S.T., Suppression of tumorigenesis and metastasis of hepatocellular of hepatocellular carcinoma by shRNA interference targeting on inhibition of homeoprotein Six1 (Paper Presentation), The 98th Annual Meeting of the American Association for Cancer Research, Los Angeles, USA, 14 - 18 April 2007. |
|
Shih K.C., Man K., Ng T.P., Xiao J., Fan S.T. and Lo C.M., Distinct gene signatures linked to acute phase injury and tumor invasiveness in tumor development after liver transplantation using small-for-size grafts (Abstract), The International Liver Transplantation Society 13th Annual International Congress, Rio de Janeiro, Brazil, 20 - 23 June 2007. |
|
Shih K.C., Man K., Ng T.P., Xiao J., Fan S.T. and Lo C.M., Rising Star Award - "Distinct gene signatures linked to acute phase injury and tumor invasiveness in tumor development after liver transplantation using small-for-size grafts", The International Liver Transplantation Society 13th Annual International Congress, Rio de Janeiro, Brazil, 20 - 23 June 2007. 2007. |
|
Researcher
: Ng WM |
|
List of Research Outputs |
|
Cense H.A., Law S.Y.K., Wei W.I., Lam L.K., Ng W.M., Wong K.H., Kwok K.F. and Wong J., Pharyngolaryngoesophagectomy using the thoracoscopic approach, Surgical Endoscopy. 2007, 21(6): 879-884. |
|
Cense H.A., Law S., Wei W.I., Lam L.K., Ng W.M., Wong K.H., Kwok K.F. and Wong J., Surg Endosc, Pharyngolaryngoesophagectomy using the thoracoscopic approach. 2007, 21: 879-884. |
|
Ng W.M. and Cheng Y.L., Calcium Alginate Dressing - Relating Hypercalcemia, Journal of Burn Care and Research. 2007, 28: 203-204. |
|
Ng W.M. and Cheng Y.L., J Burn Care Res, Calcium alginate dressing related hypercalcaemia. 2007, 28: 203-4. |
|
Ng W.M., Surgical Practice, A Training Model for End-to-Side Microvascular Anastomosis in Rat. 2006, 10: 114-116. |
|
Wei W.I. and Ng W.M., Complications of resection of malignant tumours of the skull base: outcome and solution, European Archive of Otorhinolaryngology. 2007, 264: 733-9. |
|
Wei W.I. and Ng W.M., The management of neck metastases in nasopharyngeal cancer, Current Opinion Otolaryngology Head and Neck Surgery. 2007, 15: 99-102. |
|
Yuen P.W. and Ng W.M., Laryngoscope, Surgical techniques and results of lateral thoracic cutaneous, myocutaneous, and conjoint flaps for head and neck reconstruction. 2007, 117: 288-94. |
|
Yuen P.W. and Ng W.M., Surgical techniques and results of lateral thoracic cutaneous myocutaneous, and conjoint flaps for head and neck reconstruction, The Laryngoscope. 2007, 117: 288-294. |
|
Researcher
: Ngai PP |
|
List of Research Outputs |
|
Lam C.T., Yang Z., Ngai P.P., Fan S.T. and Poon R.T.P., The potential role of brain-derived neurotrophic factor (BDNF) in angiogenesis (Poster Presentation), The 2nd European Conference on Tumor Angiogenesis and Antiangiogenic Therapy (ECTA), Munich, Germany, 14 - 16 September 2006. |
|
Lau
C.K., Yang Z., Ngai P.P., Poon R.T.P. and Fan S.T., HIF |
|
Yang Z., Ho D.W.Y., Ngai P.P., Lau C.K., Zhao Y., Poon R.T.P. and Fan S.T., Antiinflammatory properties of IL-10 rescue small-for-size liver grafts, Liver Transplantation. 2007, 13(4): 558-565. |
|
Yang Z., Lau C.K., Ngai P.P., Ho D.W.Y., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Induction of long-term liver allograft survival by delayed immunosuppression is dependent on interleukin-10 (Oral Presentation), World Transplant Congress 2006, Boston, U.S.A., 22 - 27 July 2006. |
|
Yang Z., Ngai P.P., Lau C.K., Ho D.W.Y., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Induction of long-term liver allograft survival by delayed immunosuppression is dependent on interleukin-10, Liver Transplantation. 2007, 13(4): 571-578. |
|
Researcher
: Ngan ESW |
|
Project Title: |
Sonic hedgehog (Shh) signaling in the enteric neural crest cells |
|
Investigator(s): |
Ngan ESW, Sham MH, Lui VCH, Tam PKH |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
01/2005 |
|
Completion Date: |
12/2006 |
|
Abstract: |
|
The main objectives of this project are:
1) To investigate the effect of Shh on the expression profiles of BMP-2 and
BMP |
|
Project Title: |
Novel Function(s) of Prokineticins in Neural Crest Stem Cells |
|
Investigator(s): |
Ngan ESW, Lui VCH, Tam PKH |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
01/2006 |
|
Abstract: |
|
The mammalian enteric nervous system
(ENS) is derived from the neural crest cells (NCC) which enter the foregut
and colonize the entire wall of gastrointestinal tract (1). In mice, NCCs
reach foregut at approximately embryonic day 9.4 (E9.5) and finish the
colonization by ~E14.5. Numerous gut mesenchyme/mucosa-derived factors and
their receptors on NCC are found to be crucial for NCC proliferation,
differentiation and migration. They are glial cell-line derived neurotrophic
factor (GDNF) and its receptors (RET, GFRA1)(2); endothelin 3 (EDN3) and its
receptor (EDNRB)(3); sonic hedgehog (Shh) and its receptor (Ptc)(4). A
delicate balance between these signals is a prerequisite for the proper
regulation of NCCs during ENS development. Failure to completely colonize the
gut results in the absence of enteric ganglia as seen in Hirschsprung’s
disease in human. Prokineticin –1 and -2 (Prok-1 and Prok-2), also referred
to endocrine gland derived vascular endothelial growth factor (EG-VEGF) and
Bv8, respectively, are structurally related and belong to a newly identified
family of secreted proteins, AVIT protein family. These proteins are
distributed widely in mammalian tissues. Prok-1 mRNA expression has been
described in a variety of tissues, in steroidogenic glands such as the ovary,
testis, adrenal gland and placenta, but also in the brain, colon, skeletal
muscle, small intestine, spleen, thymus liver, bladder, prostate and
uterus(5,6) . Prok-2, on the other hand, shows the highest expression in
testis, colon, brain and peripheral blood leukocytes(7,8). These two
prokineticins are known to bind to two closely related G protein-coupled
receptors, PK-R1 and PK-R2. Receptor activation leads to mobilization of
calcium, stimulation of phosphoinositide turnover, and activation of p44/p42
MAPK signaling pathways. Within distinct contexts, the receptors are likely
differentially regulated and distinct expression patterns of Prok receptors
were observed in various tissues. In the adrenal gland, only PK-R1 was
detected. In the ovary, follicular cells predominantly express PK-R1, whereas
corpus luteum-derived cells express high levels of both PK-R1 and PK-R2.
Similarly, these two receptors are also co-existing in endometrium, but at
different expression level. Therefore, it is believed that prokineticins may
have different angiogenic as well as non-angiogenic functions in different
tissues via acting on either PK-R1 or PK-R2. However, the exact role(s) of
PK-R1 and PK-R2 remains unclear. A new appreciation for the intricacy of
peptidergic GPCRs is developing, as the ligands for orphan receptors are
identified and as distinct signaling and functional responses for multiple
ligands and oligomerized receptors are demonstrated. Thus, the distinct or
overlapping expression of prokineticins and the possible heteroligomerization
of receptors may increase the functional complexity of this system (8,9). It
is currently known that prokineticins possess diverse biological functions:
they promote angiogenesis in ovary and testis; induce proliferation,
migration and fenestration of endothelial cells derived from adrenal gland ;
support neuronal survival; cause hyperalgesia of skin; promote contraction of
gastrointestinal smooth muscle; and control pain sensation and behavioral
circadian rhythms(8,9). More recently, these two receptors were also found in
human and mouse hematopoietic stem cells and specific mature blood cells,
including lymphocytes. Prokineticins can modulate growth, survival, and
function of cells of the innate and adaptive immune systems, possibly through
autocrine or paracrine signaling mechanisms(7). Given the reported expression
patterns and activities of the mammalian orthologs in brain, reproductive
tract, and cells of the immune system, the molecules seem to have subserved
similar functions across evolution. In addition to being the angiogenic
factors, prokineticins would be the universal survival/mitogenic factors for
various cells including endothelial cells, neuronal cells, lymphocytes as
well as the hematopietic stem cells. Noteworthy, prokineticins and their
receptors were detected in mouse embryo as early at E7, the role(s) of these
factors during embryonic development still remains to be disclosed. Our
preliminary data: It is known that prokineticin-1 is expressed in mouse and
human small intestine and colon. Using antibody specific to Prok-1 to perform
the immunohistochemistry study, we found that Prok-1 protein is expressed in
the mucosa and enteric neuronal plexus of the gut in the adult mouse. The
presence of Prok |
|
Project Title: |
Is thyroid transcription factor (TTF-1) the susceptibility gene for familial papillary thyroid carcinoma (PTC) predisposition |
|
Investigator(s): |
Ngan ESW, Garcia-Barcelo MM, Tam PKH, Lo CY, Khoo US |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
03/2007 |
|
Abstract: |
|
Papillary thyroid carcinoma (PTC) is the
most common malignant thyroid carcinoma, comprising an estimated 80% of
thyroid cancers. Somatic genetic alterations in PTC, including RET/PTC
rearrangements(1-4) and BRAF(5) and RAS(6) mutations have proved useful as
prognostic markers and may represent the result to a cancer initiation
process governed by the constitutive DNA endowment of the patient.
Nevertheless, these genetic alterations only account for approximately 70% of
PTC and the correlations with clinicopathological features of increase
morbidity are still inconclusive. Importantly, 3.5-6.2% of PTC patients have
one or more first-degree relatives with thyroid carcinoma, suggesting the
presence of heritable genetic determinants for PTC predisposition, but the
genetic basis of familial PTC is yet unknown. Thyroid transcription factor-1
(TTF-1) is a key player implicated in the thyroid development and associated
disorders. TTF-1 knockout mice present with a series of congenital defects
including lack of thyroid(7). Heterozygous "de novo" TTF1 mutations
inherited in an autosomal dominant manner are associated with compensated
congenital hypothyroidism(8-10). Regarding tumorigenesis, it is known to be a
differentiation marker and inversely related to the malignant phenotype of
thyroid neoplasms. More recently, it has been demonstrated that conditional
ablation of TTF |
|
List of Research Outputs |
|
Garcia-Barcelo M.M., Miao X., Lui V.C.H., So M.T., Ngan E.S.W., Leon T.Y., Lau D.K., Liu T.T., Lao X., Guo W., Holden W.T., Moore J. and Tam P.K.H., Correlation between genetic variations in Hox clusters and Hirschsrpung's disease, Annals of Human Genetics. 2007, 71(Pt 4): 526-536. |
|
Ngan E.S.W., Poon H.C., Sham M.H., Tam P.K.H. and Lui V.C.H., Aberrant KLF4 expression and BMP signaling cause proliferation defect in PTC1-/- neural crest cells (The Best Poster Presentation at the Forum), MGH-HKU-Nature China Forum, Hong Kong, 5-6 March 2007. |
|
Ngan E.S.W., Poon H.C., Sham M.H., Hui C.C., Wainwright B., Tam P.K.H. and Lui V.C.H., Aberrant Kruppel-like factor 4 expression causes proliferation defect in Patched1-/- neural crest cells, The 5th Annual Meeting of the International Society for Stem Cell Research, Cairns, Queensland, Australia, 17-20 June 2007. |
|
Ngan E.S.W., Sit Y.L.F., Lee K.Y., Miao X., Yuan Z., Wang W.L., Nicholls J.M., Wong K.K.Y., Garcia-Barcelo M.M., Lui V.C.H. and Tam P.K.H., Implications of endocrine gland - derived vascular endothelial growth factor/prokineticin-1 signaling in human neuroblastoma progression., Clinical Cancer Research. 2007, 13(3): 868-875. |
|
Ngan E.S.W., Lee K.Y., Sit Y.L.F., Poon H.C., Chan J.K.Y., Sham M.H., Lui V.C.H. and Tam P.K.H., Prokineticin-1 modulates proliferation and differentiation of enteric neural crest cells, Biochimica et Biophysica Acta. 2007, 1773(4): 536-545. |
|
Ngan E.S.W., Garcia-Barcelo M.M., Lui V.C.H. and Tam P.K.H., Prokineticins in Neural Crest Cell Growth and Associated Disorders, US Provisional Patent. 2006. |
|
Ngan
E.S.W., Lee
K.Y., Sit F.Y.L., Chan J.K.Y., Sham M.H., Lui V.C.H. and Tam P.K.H., Roles of Prokineticin |
|
Ngan E.S.W., Lui V.C.H., Garcia-Barcelo M.M. and Tam P.K.H., Signaling mechanisms regulating neural crest cells in growth & tumorigenesis [Invited Lecture - Ngan ESW], Stem Cell Workshop: Strategic Research Theme of Development and Reproduction, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, 2-3 November 2006. |
|
Ngan E.S.W., Lui V.C.H., Garcia-Barcelo M.M. and Tam P.K.H., Signaling mechanisms regulating neural crest cells: in growth and tumorigenesis (Invited Lecture), Signalling mechanisms regulating neural crest cells: in growth and tumorigenesis, Stem Cell Workshop , SRT of Development and Reproduction, Hong Kong, 2 - 3 November 2006. 2006. |
|
Ngan E.S.W., Poon H.C., Sham M.H., Hui C.C., Brandon W., Tam P.K.H. and Lui V.C.H., The Best Poster Presentation, MGH-HKU-Nature China Forum . 2007. |
|
Researcher
: Patil NG |
|
Project Title: |
Audit of deaths and complications in surgical patients admitted to university surgical unit |
|
Investigator(s): |
Patil NG |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
01/1992 |
|
Abstract: |
|
To assess: (1) quality and standard of care; (2) educational value; (3) reporting of complications; (4) incidence and prevalence of life threatening surgical conditions; (5) improvements in surgical techniques, investigation procedures, clinical practice and infrastructure. |
|
Project Title: |
Risk factors for inguinal hernia in adults: a case-control study |
|
Investigator(s): |
Patil NG, Lau H |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2002 |
|
Abstract: |
|
To evaluate and identify the risk factors for the development of inguinal hernia in adults. |
|
Project Title: |
Risk factors for hernia development in patients receiving continuous ambulatory peritoneal dialysis (CAPD) |
|
Investigator(s): |
Patil NG, Lau H |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2003 |
|
Abstract: |
|
To evaluate the incidence of and identify the risk factors for the development of hernia in patients who are undergoing CAPD. |
|
List of Research Outputs |
|
Chan J.L.Y. and Patil N.G., In: Chan Julia, Patil NG, Digby: A Remarkable Life. Hong Kong, Hong Kong University Press, 2006. |
|
Chan S.S.C., Tiwari A.F.Y., Wong E.M.Y., Wong A. and Patil N.G., Applying clinical problem-based learning (CPBL) in the undergraduate nursing curriculum: evaluation of students' approaches to learning, Association for Medical Education in Europe (AMEE), Genoa, Italy, 14-18 September 2006. |
|
Chan S.S.C., Wong E.M.Y., Tiwari A.F.Y., Lam W.W.T. and Patil N.G., Monograph: Clinical Problem-Based Learning (CPBL): An Introductory Guide. Hong Kong, The University of Hong Kong, 2007. |
|
Lau H., Fang C., Yuen W.K. and Patil N.G., Risk factors for inguinal hernia in adult males: a case-control study, Surgery. 2007, 141(2): 262-266. |
|
Patil N.G. and Chan L.C., Assessment of Medical Schools: Who cares?, AMEE, Italy. September 14-18. 2006. |
|
Patil N.G., Associate Editor, Journal of Clinical Education Resources. 2007. |
|
Patil N.G., Chairman, Problem-based learning: Promising expectation or fitting despair?, U21 Health Sciences Meeting - The University of Nottingham, Nottingham, United Kingdom, 13-15 September 2006. 2006. |
|
Patil N.G., Honorary Consultant in Surgery, Hong Kong Sanatorium & Hospital, Hong Kong. 2007. |
|
Patil N.G., Honorary Consultant in Surgery, Queen Mary Hospital, Hong Kong. 2007. |
|
Patil N.G., Honorary Consultant in Surgery, Tung Wah Hospital, Hong Kong. 2007. |
|
Patil N.G., Invited Speaker and Facilitator, "Teaching, Excellence & Recognition", International Medical Conference (IMEC - 2007), Kuala Lumpur, Malaysia, 19 - 22 April 2007. 2007. |
|
Patil N.G., Invited Speaker, Symposium on Medical Education, G.S. Medical College & King Edward VII Hospital, Mumbai, India, 21-23 December 2006. 2006. |
|
Patil N.G., Lo W.K. and Lui S.L., Peritoneal computed tomography: a diagnostic tool for gental oedema in patients on peritoneal diaglysis, Hong Kong Medical Journal. 2007, 13(1): 82-83. |
|
Patil N.G., Recognition of teaching excellence (Abstract), Abstract in International E-Journal of Science, Medicine & Education 2007. 2007, A34. |
|
Patil N.G., Recognition of teaching excellence, International Medical Education Conference 2007, Kuala Lumpur, Malaysia, 20-21 April 2007. |
|
Patil N.G., Visiting Professor, "Pain and Joy of Curriculum Department", University of Papua New Guinea, the Port Moresby General Hospital, Papua, New Guinea, 5-9 November 2006. 2006. |
|
Tang
H.N.A., Wong J.G.W.S., Patil N.G. and Mak-Lieh F., Teaching and learning of
medical professionalism - medical students' experience at the University of
Hong Kong, Cotone Congressi, Genoa, Italy (14-18 September 2006).
Genoa, Italy, Association for Medical Education in Europe, 2006, 9, |
|
Wan S.H., Lau H., Patil N.G., Lo W.K. and Lui S.K., Peritoneal computed tomograph: a diagnostic tool for genital oedema in patients on peritoneal analysis, Hong Kong Medical Journal. 2007, 13(1): 82-83. |
|
Researcher
: Poon HC |
|
List of Research Outputs |
|
Ngan E.S.W., Poon H.C., Sham M.H., Tam P.K.H. and Lui V.C.H., Aberrant KLF4 expression and BMP signaling cause proliferation defect in PTC1-/- neural crest cells (The Best Poster Presentation at the Forum), MGH-HKU-Nature China Forum, Hong Kong, 5-6 March 2007. |
|
Ngan E.S.W., Poon H.C., Sham M.H., Hui C.C., Wainwright B., Tam P.K.H. and Lui V.C.H., Aberrant Kruppel-like factor 4 expression causes proliferation defect in Patched1-/- neural crest cells, The 5th Annual Meeting of the International Society for Stem Cell Research, Cairns, Queensland, Australia, 17-20 June 2007. |
|
Ngan E.S.W., Lee K.Y., Sit Y.L.F., Poon H.C., Chan J.K.Y., Sham M.H., Lui V.C.H. and Tam P.K.H., Prokineticin-1 modulates proliferation and differentiation of enteric neural crest cells, Biochimica et Biophysica Acta. 2007, 1773(4): 536-545. |
|
Ngan E.S.W., Poon H.C., Sham M.H., Hui C.C., Brandon W., Tam P.K.H. and Lui V.C.H., The Best Poster Presentation, MGH-HKU-Nature China Forum . 2007. |
|
Researcher
: Poon HC |
|
List of Research Outputs |
|
Ngan E.S.W., Poon H.C., Sham M.H., Tam P.K.H. and Lui V.C.H., Aberrant KLF4 expression and BMP signaling cause proliferation defect in PTC1-/- neural crest cells (The Best Poster Presentation at the Forum), MGH-HKU-Nature China Forum, Hong Kong, 5-6 March 2007. |
|
Ngan E.S.W., Poon H.C., Sham M.H., Hui C.C., Wainwright B., Tam P.K.H. and Lui V.C.H., Aberrant Kruppel-like factor 4 expression causes proliferation defect in Patched1-/- neural crest cells, The 5th Annual Meeting of the International Society for Stem Cell Research, Cairns, Queensland, Australia, 17-20 June 2007. |
|
Ngan E.S.W., Lee K.Y., Sit Y.L.F., Poon H.C., Chan J.K.Y., Sham M.H., Lui V.C.H. and Tam P.K.H., Prokineticin-1 modulates proliferation and differentiation of enteric neural crest cells, Biochimica et Biophysica Acta. 2007, 1773(4): 536-545. |
|
Ngan E.S.W., Poon H.C., Sham M.H., Hui C.C., Brandon W., Tam P.K.H. and Lui V.C.H., The Best Poster Presentation, MGH-HKU-Nature China Forum . 2007. |
|
Researcher
: Poon JTC |
|
List of Research Outputs |
|
Chan Y.C., Ting A.C.W., Ho P., Poon J.T.C., Yiu W.K. and Cheng S.W.K., Supra-aortic hybrid endovascular procedures for complex thoracic aortic disease (Best Paper Session), Conjoint Scientific Congress of the Royal College of Surgeons of England and the College of Surgeons of Hong Kong, Hong Kong, 6-7 May 2007. |
|
Chan Y.C., Ting A.C.W., Poon J.T.C., Yiu W.K., Cheung G.C.Y. and Cheng S.W.K., Ten year epidemiological review of in-hospital patients with Marfan syndrome, Conjoint Scientific Congress of the Royal College of Surgeons of England and the College of Surgeons of Hong Kong, Hong Kong, 6-7 May 2007. |
|
Ho P., Cheng S.W.K., Ting A.C.W., Poon J.T.C. and Liu L.H.L., Hybrid endovascular operation for ruptured thoracic aortic aneurysm (Case report), Hong Kong Medical Journal. 2007, 13(1): 78-80. |
|
Ting A.C.W., Cheng S.W.K., Ho P. and Poon J.T.C., Endovascular stent graft repair for infected thoracic aortic pseudoaneurysms - a durable option?, Journal of Vascular Surgery. 2006, 44(4): 701-705. |
|
Researcher
: Poon RTP |
|
Project Title: |
Prospective
randomized trial of radiofrequency ablation versus hepatic resection for
hepatocellular carcinoma <= |
|
Investigator(s): |
Poon RTP, Fan ST |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
12/2002 |
|
Abstract: |
|
The project attempts to compare the
immediate and long-term outcomes between radiofrequency ablation (RFA) nad
hepatic resection for patients with hepatocellular carcinoma (HCC) less than
or equal to |
|
Project Title: |
Enhancement of therapeutic efficacy of hypoxia and chemotherapy in hepatocellular carcinoma by blockade of vascular endothelial growth factor receptors |
|
Investigator(s): |
Poon RTP, Yang Z |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
09/2005 |
|
Abstract: |
|
To study whether antiangiogenic therapy using a tyrosine inhibitor of VEGF receptors, PTK 787, can enhance the efficacy of chemotherapy and tumor hypoxia treatment for hepatocellular carcinoma (HCC) in a rat orthotopic HCC model. GF |
|
Project Title: |
Identification of Rac as a novel therapeutic target in hepatocellular carcinoma metastasis |
|
Investigator(s): |
Poon RTP, Lee KW |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
09/2005 |
|
Completion Date: |
08/2006 |
|
Abstract: |
|
Hepatocellular carcinoma (HCC) is a highly malignant tumor which is characterized by active neovascularization (Poon et al., Ann. Surg., 2001;233:227-35). It is the fifth most common malignancy worldwide (Kuper et al., Hepatology, 2001;34:714-8; Tang, World J. Gastroenterol., 2001;7:445-54). The poor prognosis of HCC is commonly associated with propensity for vascular invasion and metastasis (Tang, World J. Gastroenterol., 2001;7:445-54). It has been previously shown that angiogenesis makes significant contribution to tumor growth, invasiveness, and metastatic potential of HCC (Poon et al., J. Clin. Oncol., 2001,19:1207-25; Sugimachi et al., Surgery, 2002;131:S135-41; Tanigawa et al., Hepatology, 1997;26:1216-23). The degree of angiogenesis in a tumor is the net result reflecting complex interactions of various proangiogenic factors and antiangiogenic factors, secreted by tumor cells, vascular endothelial cells, and infiltrating cells. Switching to angiogenic phenotype involves the up-regulation of proangiogenic factors, down-regulation of antiangiogenic factors, or both. Thus far, there are limited data on the role of various proangiogenic factors in HCC (Poon et al., Ann. Surg., 2003; 238:9-28). Vascular endothelial growth factor (VEGF) is a potent angiogenic factor that plays a central role in angiogenesis in various cancer types (Toi et al., Lancet Oncol., 2001;2:667-73). A previous study from our group has reported that VEGF is a potent angiogenic factor leading to HCC invasiveness (Ng et al., Am. J. Clin. Pathol., 2001;116:838-45). However, the mechanism by which VEGF is regulated is far from understood. Understanding the underlying regulatory mechanism of VEGF allows the development of novel therapies targeting at the inhibition of HCC invasiveness so that patients’ survival can be improved. Cell motility is an important factor in the progression and metastasis of HCC. Family members of the Rho-like GTPases, including Cdc42, Rac1, and RhoA, have been found to play important roles in distinct actin cytoskeleton changes that were required for cell adhesion, migration, and invasion (Hall, Science, 1998;279:509-14) Recently, we first demonstrated the significance of Rac signaling pathway in HCC cell motility (Lee et al., Carcinogenesis, 2005;26:681-7). An elevated Rac-GTP level was found in the metastatic HCC cell line compared with the primary HCC cell line. The higher level of Rac-GTP accompanied with activated SAPK/JNK pathway was correlated with HCC cell motility (Lee et al., Carcinogenesis, 2005;26:681-7). Apart from its effect on cell motility, Rac activation may play a role in angiogenesis. This hypothesis is based on the observation that there was a significant correlation between the decrease in Rac protein level and decrease in VEGF and CD34 protein expression in HCC metastatic tumor model upon administration of a novel immunosuppressive drug, FTY720 (Lee et al., Clin. Cancer Res., in press).This possible interaction between Rac and VEGF has been recently supported by our in vitro experiment showing upregulation of VEGF expression upon transfection of Rac-dominant active into Hep3B cell. To my knowledge, this is the first study showing a direct link between Rac and VEGF expression. Given a central role of VEGF in cancer angiogenesis, it is of great interest to elucidate whether Rac activation promotes cancer angiogenesis by interacting with VEGF expression. In this study, we hypothesized that Rac might promote HCC metastasis by acting as an angiogenic factor through upregulation of VEGF expression. Although the angiogenic role of Rac has been suggested, the underlying mechanism has not been studied so far. Understanding its molecular mechanism allows future development of novel therapies targeting angiogenesis in HCC. The long term goal of this project is to elucidate the molecular mechanism responsible for Rac mediated angiogenesis in HCC metastasis and eventually facilitate the development of new therapeutic strategies against HCC metastasis and recurrence. There are three mains specific objectives of this study: 1. Determine the correlation between Rac activation and VEGF expression in HCC clinical samples 2. Determine the signaling pathways of Rac medicated VEGF upregulation in HCC 3. Determine the effect of Rac inactivation on angiogenesis of HCC |
|
Project Title: |
Training courses on radiofrequency ablation for liver cancers |
|
Investigator(s): |
Poon RTP, Fan ST, Lam CM, Tso WK |
|
Department: |
Surgery |
|
Source(s) of Funding: |
S.K. Yee Medical Foundation - General Award |
|
Start Date: |
12/2005 |
|
Abstract: |
|
To provide comprehensive training courses
for doctors from Hong Kong, Macau and |
|
Project Title: |
Study on the
role of Id |
|
Investigator(s): |
Poon RTP, Lee KW |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
10/2006 |
|
Abstract: |
|
Hepatocellular carcinoma (HCC) is a
highly malignant tumor characterized by active neovascularization (Poon RTP
et al, Br J Surgery 2004; 91:1354-60). It is the fifth most common malignancy
worldwide and the second leading cause of cancer death in |
|
Project Title: |
Senisitization of hepatocellular carcinoma (HCC) to hypoxia and chemotherapy by inhibition of hypoxia inducible factor-1α (HIF-1&ALPHA;) |
|
Investigator(s): |
Poon RTP, Yang Z |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
12/2006 |
|
Abstract: |
|
To study whether inhibition of hypoxia-inducible factor 1α (HIF-1α) activity can inhibit the growth or survival of tumor cells and suppress angiogenic activities of endothelial cells under hypoxic condition in vitro; to study whether inhibition of HIF-1αactivity can enhance the efficacy of hypoxia and chemotherapy treatment for hepatocellular carcinoma (HCC) in vitro in a rat orthotopic HCC model. |
|
Project Title: |
A study of the effect of vascular endothelial growth factor (VEGF) on chemoresistance of hepatocellular carcinoma (HCC) and blockade of VEGF to enhance chemosensitivity of HCC |
|
Investigator(s): |
Poon RTP, Yang Z |
|
Department: |
Surgery |
|
Source(s) of Funding: |
NSFC/RGC Joint Research Scheme |
|
Start Date: |
01/2007 |
|
Abstract: |
|
To study the effect of VEGF on chemoresistance of HCC; to investigate the possible mechanism of VEGF-induced chemoresistance in HCC; to study whether inhibition of VEGF could increase chemosensitivity of HCC. |
|
List of Research Outputs |
|
Chan A., Poon R.T.P., Mh K.C., Chan S.C., Yuen W.K., Yeung C., Lo C.M. and Fan S.T., Effect of changing paradigm for management of hepatocellular carcinoma on the long-term survival of patients with hepatocellular carcinoma (Abstract), The 1st Biennial Congress of the Asian-Pacific Hepato-Pancreato-Biliary Association, Fukuoka, Japan, 20 - 23 March 2007. |
|
Cheng Q., Man K., Ng T.P., Lo C.M., Poon R.T.P. and Fan S.T., The significance of hepatic stellate cell activation on small-for-size fatty liver graft injury (Abstract), The International Liver Transplantation Society 13th Annual International Congress, Rio de Janeiro, Brazil, 20 - 23 June 2007. |
|
Chik B.H., Liu C.L., Fan S.T., Lo C.M., Poon R.T.P., Lam C.M. and Wong J., Tumor size and operative risks of extended right-sided hepatic resection for hepatocellular carcinoma: implication for preoperative portal vein embolization, Archives of Surgery. 2007, 142(1): 63-69. |
|
Chok K.S.H., Ng K.K.C., Poon R.T.P., Lam C.M., Yuen J.H.F., Tso W.K. and Fan S.T., Comparable survival in patients with unresectable hepatocellular carcinoma treated by radiofrequency ablation or transarterial chemoembolization, Archives of Surgery. 2006, 141(12): 1231-1236. |
|
Chow D.H.F., Sinn L.H.Y., Ng K.K.C., Lam C.M., Yuen J.H.F., Fan S.T. and Poon R.T.P., Radiofrequency ablation for hepatocellular carcinoma and metastatic liver tumors: a comprative study, Journal of Surgical Oncology. 2006, 94(7): 565-571. |
|
Ho
D.W.Y., Yang Z., Lau C.K., Tam K.H., To J.Y.T., Poon R.T.P. and Fan S.T., Therapeutic potential of
cardiotrophin |
|
Ho J.W.Y., Pang R.W.C., Lau C.P.Y., Sun K.W., Yu W.C., Fan S.T. and Poon R.T.P., Significance of circulating endothelial progenitor cells in hepatocellular carcinoma, Hepatology. 2006, 44(4): 836-843. |
|
Hui C.K., Lau E., Monto A., Kim M., Luk J.M.C., Poon R.T.P., Leung N., Lo C.M., Fan S.T., Lau G. and Wright T.L., Natural history of patients with recurrent chronic hepatitis C virus and occult hepatitis B co-infection after liver transplantation, American Journal of Transplantation. 2006, 6(7): 1600-1608. |
|
Lai L., Hui C.K., Poon R.T.P., Shek T.W.H., Lai S.T., Lai J.Y., Lo C.M., Fan S.T., Leung N. and Lau G., The use of transient elastography as a preoperative assessment of hepatic resection (Abstract), The 17th Asian Pacific Association for the Study of the Liver Conference, Kyoto, Japan, 27 - 30 March 2007. Hepatology International. 2007, 1(1): 51. |
|
Lam C.T., Yang Z., Ngai P.P., Fan S.T. and Poon R.T.P., The potential role of brain-derived neurotrophic factor (BDNF) in angiogenesis (Poster Presentation), The 2nd European Conference on Tumor Angiogenesis and Antiangiogenic Therapy (ECTA), Munich, Germany, 14 - 16 September 2006. |
|
Lam C.T., Yang Z., Fan S.T. and Poon R.T.P., The potential role of brain-derived neurotrophic factor (BDNF) in angiogenesis (Poster Presentation), The 98th Annual Meeting of the American Association for Cancer Research, Los Angeles, USA, 14 - 18 April 2007. |
|
Lau
C.K., Yang Z., Ngai P.P., Poon R.T.P. and Fan S.T., HIF |
|
Lau
C.K., Yang Z., Poon R.T.P. and Fan S.T., HIF |
|
Lau C.K., Yang Z., Lam C.T., Tam P.K.H., Poon R.T.P. and Fan S.T., Suppression of hypoxia inducible factor-1a (HIF-1a) by YC-1 is dependent on murine double minute 2 (MDM2), Biochemical and Biophysical Research Communications. 2006, 348(4): 1443-1448. |
|
Lau C.P., Poon R.T.P., Cheung S.T., Yu W.C. and Fan S.T., SPARC and Hevin expression correlate with tumour angiogenesis in hepatocellular carcinoma, Journal of Pathology. 2006, 210(4): 459-468. |
|
Lee K.W., Poon R.T.P., Yuen P.W., Man K., Yang Z., Guan X.Y. and Fan S.T., Rac activation is associated with hepatocellular carcinoma metastasis by up-regulation of vascular endothelial growth factor expression, Clinical Cancer Research. 2006, 12(17): 5082-5089. |
|
Lee K.W., Poon R.T.P., Yuen P.W., Ling M.T., Wang X., Wong Y.C., Guan X.Y., Man K., Tang Z.Y. and Fan S.T., Regulation of angiogenesis by Id-1 through hypoxia-inducible factor-1 mediated vascular endothelial growth factor up-regulation in hepatocellular carcinoma, Clinical Cancer Research. 2006, 12(23): 6910-6919. |
|
Lee K.W., Man K., Poon R.T.P., Lo C.M., Yuen P.W., Ng I.O.L., Ng T.P., Leonard W. and Fan S.T., Signal transducers and activators of transcription 5b activation enhances hepatocellular carcinoma aggressiveness through induction of epithelial-mesenchymal transition, Cancer Research. 2006, 66(20): 9948-9956. |
|
Lee K.W., Poon R.T.P., Yuen P.W., Ling M.T., Kwok W.K., Wang X., Wong Y.C., Guan X.Y., Man K., Chau K.L. and Fan S.T., Twist overexpression correlates with hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition, Clinical Cancer Research. 2006, 12(18): 5369-5376. |
|
Lee
P.P.W., Lee W.Y., Yuen R.M.F., Poon R.T.P. and Lau Y.L., Gene association study on
development of hepatic fibrosis in chronic hepatitis B among Hong Kong
Chinese. , The 8th International Meeting on Human Genome Variation and
Complex Genome Analysis, |
|
Lee T.K., Man K., Poon R.T.P., Lo C.M., Yuen P.W., Ng I.O., Ng K.T., Leonard W. and Fan S.T., Cancer Res., Signal transducers and activators of transcription 5b activation enhances hepatocellular carcinoma aggressiveness through induction of epithelial-mesenchymal transition. 2006, 66: 9948-56. |
|
Lee T.K., Poon R.T.P., Yuen P.W., Ling M.T., Kwok W.K., Wang X.H., Wong Y.C., Guan X.Y., Man K., Chau K.L. and Fan S.T., Clin Cancer Res., Twist overexpression correlates with hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition. 2006, 12: 5369-76. |
|
Lee T.K., Poon R.T.P., Yuen P.W., Man K., Yang Z., Guan X.Y. and Fan S.T., Clin Cancer Res, Rac activation is associated with hepatocellular carcinoma metastasis by up-regulation of vascular endothelial growth factor expression. 2006, 12: 5082-9. |
|
Lee T.K., Poon R.T.P., Yuen P.W., Ling M.T., Wang X.H., Wong Y.C., Guan X.Y., Man K., Tang Z.Y. and Fan S.T., Clin Cancer Res, Regulation of angiogenesis by Id-1 through hypoxia-inducible factor-1alpha-mediated vascular endothelial growth factor up-regulation in hepatocellular carcinoma. 2006, 12: 6910-9. |
|
Lee
W.Y., Lee P.P.W., Yuen R.M.F., Poon R.T.P. and Lau Y.L., Association of
Interferon-gamma (IFN-g) Polymorphisms with Susceptibility of Hepatitis B
Virus (HBV) Infection in the Hong Kong Chinese. , "European Human
Genetics Conference, Nice, |
|
Lee W.Y., Lee P.P.W., Wong W.H.S., Yuen R.M.F., Poon R.T.P., Lai C.L., Fan S.T. and Lau Y.L., Association of Transforming Growth Factor-Beta 1 (TGF-b1) Polymorphisms with Hepatitis B Virus (HBV) Related Fibrosis and Cirrhosis in the Hong Kong Chinese, 11th Research Postgraduate Symposium, Hong Kong, 7 December 2006. |
|
Liu Y., Poon R.T.P., Shao W., Sun X., Chen H., Kok T.W. and Fan S.T., Blockage of epidermal growth factor receptor by quinazoline tyrosine kinase inhibitors suppresses growth of human hepatocellular carcinoma, Cancer Letters. 2007, 248(1): 32-40. |
|
Liu Y., Lei L., Lui E.L.H., Lau C.P.Y., Chen Y., Wo Y.H., Fan S.T. and Poon R.T.P., Tyrosine kinase inhibitor PTK 787/ZK222584 inhibits liver fibrosis (Abstract), The 17th Asian Pacific Association for the Study of the Liver Conference, Kyoto, Japan, 27 - 30 March 2007. Hepatology International. 2007, 1(1): 206. |
|
Lo C.M., Liu C.L., Chan S.C., Lam C.M., Poon R.T.P., Ng I.O.L., Fan S.T. and Wong J., A randomized, controlled trial of postoperative adjuvant interferon therapy after resection of hepatocellular carcinoma, Annals of Surgery. 2007, 245(6): 831-842. |
|
Luk J.M.C. and Poon R.T.P., Blue Sky Project - Molecular Profiling of Hepatocellular Carcinoma, HKU-Rosetta Inpharmatics LLC Agreement. 2007, LK46307. |
|
Man K., Xiao J., Ng T.P., Cheng Q., Sun B., Wang Y., Sun K.W., Poon R.T.P. and Lo C.M., Adiponectin as a novel therapy for the suppression of the liver cancer growth and metastasis (Paper Presentation), the 14th European Organisation for the Research and Treatment of Cancer, National Cancer Institute, and American Association for Cancer Research (EORTC-NCI-AARC) Symposium on Molecular Targets and Cancer Therapeutics, Prague, Czech Republic, 7 - 10 November 2006. European Journal of Cancer Supplement. 2006, 50. |
|
Man K., Xiao J., Ng T.P., Cheng Q., Sun K.W., Lo C.M., Poon R.T.P. and Fan S.T., Combination therapy for liver tumor growth and metastasis by low dose rapamycin and FTY720 (Paper Presentation), the 14th European Organisation for the Research and Treatment of Cancer, National Cancer Institute, and American Association for Cancer Research (EORTC-NCI-AARC) Symposium on Molecular Targets and Cancer Therapeutics, Prague, Czech Republic, 7 - 10 November 2006. |
|
Man K., Ng T.P., Xu A.M., Cheng Q., Sun B., Sun K.W., Lee K.W., Lo C.M., Poon R.T.P. and Fan S.T., Fat-derived hormone adiponectin suppresses liver tumor growth and metastases (Paper Presentation), The 98th Annual Meeting of the American Association for Cancer Research, Los Angeles, USA, 14 - 18 April 2007. |
|
Ng K.K.C., Poon R.T.P., Lo C.M., Yuen J.H.F., Tso W.K. and Fan S.T., Analysis of recurrence pattern and its influence on survival outcome after radiofrequency ablation of hepatocellular carcinoma (Grassi Prize Finalist Presentation), The 20th World Congress of the International Society for Digestive Surgery 2006, Rome, Italy, 29 November - 2 December 2006. 2006. |
|
Ng K.K.C., Poon R.T.P., Lo C.M., Yuen J.H.F., Tso W.K. and Fan S.T., Analysis of recurrence pattern and survival outcome after radiofrequency ablation of hepatocellular carcinoma: a single institution experience (Abstract), Surgical Practice. 2006, 10: A1. |
|
Ng K.K.C., Poon R.T.P., Lo C.M. and Fan S.T., Comparison of laparoscopic and open hepatectomy for small hepatocellular carcinoma (Oral Presentation), The 20th World Congress of the International Society for Digestive Surgery 2006, Rome, Italy, 29 November - 2 December 2006. 2006. |
|
Ng K.K.C., Poon R.T.P., Lo C.M. and Fan S.T., Comparison of laparoscopic and open hepatectomy for small hepatocellular carcinoma (Oral Presentation), The Congress of Endoscopic and Laparoscopic Surgeons of Asia 2006, Seoul, Korea, 18 - 21 October 2006. 2006. |
|
Ng
T.P., Man K., Sun K.W., Lee K.W., Poon R.T.P., Lo C.M. and Fan S.T., Clinicopathological
significance of homeoprotein Six |
|
Ng
T.P., Man K., Ho J.W.Y., Sun K.W., Lee K.W., Zhao Y., Lo C.M., Poon R.T.P. and Fan S.T., Marked suppression of tumor
growth by FTY |
|
Ng T.P., Man K., Cheng Q., Sun B., Lee K.W., Poon R.T.P., Lo C.M. and Fan S.T., Suppression of tumorigenesis and metastasis of hepatocellular of hepatocellular carcinoma by shRNA interference targeting on inhibition of homeoprotein Six1 (Paper Presentation), The 98th Annual Meeting of the American Association for Cancer Research, Los Angeles, USA, 14 - 18 April 2007. |
|
Pang R.W.C. and Poon R.T.P., Angiogenesis and antiangiogenic therapy in hepatocellular carcinoma, Cancer Letters. 2006, 242(2): 151-167. |
|
Pang R.W.C. and Poon R.T.P., Clinical implications of angiogenesis in cancers, Vascular Health and Risk Management. 2006, 2(2): 97-108. |
|
Pang R.W.C., Tse E.W.C. and Poon R.T.P., Molecular pathways in hepatocellular carcinoma, Cancer Letters . 2006, 240(2): 157-169. |
|
Pang R.W.C., Lee K.W., Man K., Poon R.T.P., Fan S.T., Kwong Y.L. and Tse E.W.C., PIN1 expression contributes to hepatic carcinogenesis, Journal of Pathology. 2006, 210(1): 19-25. |
|
Pang R.W.C., Lee K.W., Poon R.T.P., Fan S.T., Wong K.B., Kwong Y.L. and Tse E.W.C., Pin1 interacts with a specific serine-proline motif in hepatitis B virus X-protein to enhance hepatocarcinogenesis, Gastroenterology. 2007, 132(3): 1088-1103. |
|
Pang
R.W.C., Poon R.T.P., Fan S.T., Kwong Y.L. and Tse E.W.C., Pin1: a novel regulator of
tumor angiogenesis and invasiveness in hepatocellular carcinoma (Abstract), The
17th Asian Pacific Association for the Study of the Liver Conference, |
|
Poon R.T.P., Ng K.K.C., Tso W.K., Woo R., Pang R.W.C., Tai K.S. and Fan S.T., A phase I/II trial of transarterial chemoembolization for hepatocellular carcinoma using a novel intrarterial drug eluting beads (Abstract), The 5th International Hepatocellular Carcinoma Meeting: Eastern and Western Experiences, Houston, USA, 11 - 13 January 2007. |
|
Poon
R.T.P., Ablative therapies for liver
metastasis (Symposium Lecture), The 13th Hong Kong International Cancer
Congress, |
|
Poon R.T.P., Advances and controversies in surgical management of liver diseases (Keynote Lecture), The 10th World Congress of the International Hepato-Pancreatico-Biliary Association, Edinburgh, U.K., 3 - 7 September 2006. 2006. |
|
Poon R.T.P., Angiogenesis and the role and safety of anti-VEGF in hepatocellular cancer (Invited Lecture), The 5th Roche Asia Oncology Forum, Hong Kong, China, 5 November 2006. 2006. |
|
Poon
R.T.P., Angiogenesis in hepatocellular
carcinoma and clinical implications (Keynote Lecture), The 9th
International Congress on Hepatocellular Carcinoma: From Molecular Basis to
Clinical Medicine, |
|
Poon R.T.P., Associate Editor (2006 - present), HBP Surgery. 2007. |
|
Poon
R.T.P., Tam K.H., Yang Z. and Fan S.T., Both p53 dependent and
independent pathways contribute to RAD001 mediated enhancement of
chemo-sensitivity in hepatocellular carcinoma (Poster Presentation), The
98th Annual Meeting of the American Association for Cancer Research, |
|
Poon R.T.P., Branch-chain amino acids supplementation in management of hepatocellular carcinoma (Seminar Lecture), Annual Congress of Asia-Pacific Association for the Study of Liver, Kyoto, Japan, 27 - 29 March 2007. 2007. |
|
Poon R.T.P., Chairman - Free Paper Session on Ablative Therapies for HCC, The 1st Biennial Congress of the Asian-Pacific Hepato-Pancreato-Biliary Association, Fukuoka, Japan, 20 - 23 March 2007. 2007. |
|
Poon
R.T.P., Chairman - Symposium
"Controversies in Hepatic Surgery", The 20th World Congress of
Digestive Surgery, |
|
Poon
R.T.P., Chairman - Symposium "Management
of Liver Metastases", The 13th Hong Kong International Cancer
Congress, |
|
Poon
R.T.P., Chairman - Symposium "The
Visionary Laboratory", Hong Kong Surgical Forum, |
|
Poon
R.T.P., Chairman - Symposium on Biology of
Hepatocellular Carcinoma, The 5th International Hepatocellular Carcinoma
Meeting: Eastern and Western Experiences, |
|
Poon
R.T.P., Chairman - Symposium on Cancer, The
5th Frontiers in Biomedical Research, |
|
Poon
R.T.P., Chairman and Adjudicator - Young
Investigator Award Paper Session, The 13th Hong Kong International Cancer
Congress, |
|
Poon
R.T.P., Co-Chairman, Programme Committee,
The 2nd World Conference on Interventional Oncology, |
|
Poon
R.T.P., Combined resection and radiofrequency
ablation for liver tumors (Symposium Lecture), The 2nd World Conference on
Interventional Oncology, |
|
Poon
R.T.P., Committee Member (2002 - present), Organizing
Committee, The 1st - 6th Frontiers in Biomedical Research, Faculty of
Medicine, The University of |
|
Poon
R.T.P., Committee Member (2006 - present), Central
Committee on Liver Diseases, Hospital Authority, |
|
Poon R.T.P., Committee Member (2006 - present), Scientific Committee and Research Committee, International Hepato-Pancreato-Biliary Association. 2007. |
|
Poon R.T.P., Committee Member of Research Support for Higher Surgical Trainees Committee (2003 - present), The College of Surgeons of Hong Kong. 2007. |
|
Poon R.T.P., Committee Member, International Organizing Committee, The 17th Asian Pacific Association for the Study of the Liver Conference, Kyoto, Japan, 27 - 30 March 2007 . 2007. |
|
Poon R.T.P., Course Director, The 2nd Workshop on Radiofrequency Ablation for Liver Tumors, The Hong Kong Society of Interventional Radiology and Departments of Surgery and Radiology, Queen Mary Hospital, Hong Kong, 10 - 11 November 2006. 2006. |
|
Poon
R.T.P., Current results of liver resection
for hepatocellular carcinoma (Visiting Professor Lecture), |
|
Poon R.T.P., Current results of radiofrequency ablation for hepatocellular carcinoma (Invited Lecture), The 2nd Radiofrequency Ablation Course jointly organized by Department of Surgery and Department of Radiology, Queen Mary Hospital and The Hong Kong Society of Interventional Radiology, Hong Kong, 11 November 2006. 2006. |
|
Poon
R.T.P., Current role of laparoscopic surgery
in the management of liver malignancies, In: Szabo Z, Coburg AJ, Savalgi RS
& Reich H (eds), Surgical Technology International. |
|
Poon R.T.P., Current status and perspective of hepatic resection and transplantation for hepatocellular carcinoma in Asia (Symposium Lecture), The 43rd Annual Meeting of Liver Cancer Study Group of Japan, Tokyo, Japan, 21 - 22 June 2007. 2007. |
|
Poon
R.T.P., Current techniques of liver resection
(Symposium Lecture), Annual Meeting of American Association of
Hepato-pancreato-biliary Association, |
|
Poon R.T.P., Deputy Chairman (2003 - present), Institutional Review Board of West Cluster Hospitals and The University of Hong Kong. 2007. |
|
Poon
R.T.P., Fan
S.T., Lo C.M., Liu C.L. and Wong J., Difference in tumor invasiveness
in cirrhotic patients with hepatocellular carcinoma fulfilling the |
|
Poon
R.T.P., Differences in surgical management
for hepatocellular carcinoma between Western and Eastern countries (Lecture),
2006 International Hepatobiliary Symposium of P.R. China, |
|
Poon
R.T.P., Editor (August 2005 - present), Cutting
Edge (College Newsletter), The |
|
Poon R.T.P., Fan S.T., Lo C.M., Ng K.K.C., Yuen W.K., Yeung C. and Wong J., External drainage of pancreatic duct with a stent to reduce leakage rate of pancreaticojejunostomy after pancreaticoduodenectomy: a prospective randomized trial (Abstract), Annual Meeting of American Surgical Association, Colorado Springs, USA, 26 - 28 April 2007. |
|
Poon R.T.P., Founding Board Member (2006 - present), The International Liver Cancer Association. 2007. |
|
Poon R.T.P., Hepatic tumor ablation: long-term outcomes for hepatocellular carcinoma (Symposium Lecture), Annual Meeting of Society of American Gastrointestinal and Endoscopic Surgeons, Las Vegas, USA, 19 - 22 April 2007. 2007. |
|
Poon
R.T.P., Hepatocellular carcinoma and liver
metastasis imaging: what does a surgeon need to know? (Symposium Lecture), Cancer
Imaging 2007, The Annual Meeting of International Cancer Imaging Society, |
|
Poon R.T.P., Lau C.P.Y., Pang R.W.C., Ng K.K.C., Yuen J.H.F. and Fan S.T., High serum vascular endothelial growth factor levels predict poor prognosis after radiofrequency ablation of hepatocellular carcinoma: importance of tumor biomarker in ablative therapies, Annals of Surgical Oncology. 2007, 14(6): 1835-1845. |
|
Poon R.T.P., Impact of radiofrequency ablation on management of liver cancers (Visiting Professor Lecture), Department of Surgery, Mayo Clinic, Rochester, USA, 14 May 2007. 2007. |
|
Poon
R.T.P., International Health Professional of
the Year 2007, Research and Advisory Board, International Biographical
Centre, |
|
Poon R.T.P., International perspective on management of HCC - Hong Kong(Symposium Lecture), The 2nd World Conference on Interventional Oncology, Washington DC, USA, 14 - 17 May 2007. 2007. |
|
Poon
R.T.P., Intraoperative radiofrequency
ablation for hepatocellular carcinoma (Invited Lecture), The 5th
International Hepatocellular Carcinoma Meeting: Eastern and Western
Experiences, |
|
Poon R.T.P., James IV Travelling Fellowship 2007, James IV Association of Surgeons. 2007. |
|
Poon
R.T.P., Live donor liver transplantation for
hepatocellular carcinoma: Eastern experience (Symposium Lecture), The 5th
International Hepatocellular Carcinoma Meeting: Eastern and Western
Experiences, |
|
Poon
R.T.P. and Fan
S.T., Liver resection in cirrhosis of the liver, In: Blumgart L &
Belghiti J (eds), Surgery of the Liver, Biliary Tract and Pancreas. 4th
Edition. |
|
Poon
R.T.P., Liver transection techniques (Keynote
Lecture), The 10th World Congress of the International
Hepato-Pancreatico-Biliary Association, |
|
Poon
R.T.P., Liver transplantation for single HCC
< |
|
Poon R.T.P., Member of Editorial Board (2007 - present), Annals of Surgical Oncology. 2007. |
|
Poon R.T.P., Member of Editorial Board (2007 - present), Journal of Gastrointestinal Surgery. 2007. |
|
Poon
R.T.P., Member of Liver Oncology Research
Panel, The Society of Interventional |
|
Poon R.T.P., Member of Research Committee (2005 - present), The College of Surgeons of Hong Kong. 2007. |
|
Poon
R.T.P., Member of Steering Committee (2006 -
present), Cooperative |
|
Poon R.T.P., Molecular pathways and markers of hepatocellular carcinoma (Visiting Professor Lecture), MD Anderson Cancer Center, The University of Texas, USA, 10 January 2007. 2007. |
|
Poon R.T.P., Optimal initial treatment for early hepatocellular carcinoma in patients with preserved liver function: transplantation or resection?, Annals of Surgical Oncology. 2007, 14(2): 541-547. |
|
Poon
R.T.P., Pancreaticojejunostomy with external
pancreatic drainage (Symposium Lecture), The 20th World Congress of
Digestive Surgery, |
|
Poon
R.T.P., Panel Member of Biology and Medicine
Panel for Competitive Earmarked Research Grants (September 2006 - June 2008),
Research Grants Council, University Grants Committee, |
|
Poon R.T.P., Panel member - Tumor Board and Case Discussion on HCC, The 2nd World Conference on Interventional Oncology, Washington DC, USA, 14 - 17 May 2007. 2007. |
|
Poon
R.T.P., Permanent Committee Member (2004 -
present), International Hepatocellular Carcinoma Meeting, |
|
Poon R.T.P., Permanent Council Member (2007 - present), Eastern-Western Association on Hepatocellular Carcinoma. 2007. |
|
Poon R.T.P., Prognostic significance of circulating vascular endothelial growth factor in patients with hepatocellular carcinoma, Thesis, Doctor of Philosophy. 2006. |
|
Poon R.T.P., Recent advances and controversies in surgical management of liver diseases (Guest Editorial), HPB. 2007, 9(2): 83-86. |
|
Poon
R.T.P., Recent advances in management of
hepatocellular carcinoma (Visiting Professor Lecture), Combined HBP
Meeting, Mayo Clinic, |
|
Poon
R.T.P., Recent advances in surgical treatment
of hepatocellular carcinoma (Visiting Professor Lecture), Surgical Grand
Round, |
|
Poon
R.T.P., Resection before transplantation for
hepatocellular carcinoma (Symposium Lecture), The 5th International
Hepatocellular Carcinoma Meeting: Eastern and Western Experiences, |
|
Poon R.T.P., Role of ablative therapy for unresectable liver metastasis (Invited Lecture), The 20th World Congress of Digestive Surgery, Rome, Italy, 29 November - 2 December 2006. 2006. |
|
Poon R.T.P., Role of branch-chain amino acids supplementation in management of hepatocellular carcinoma (Seminar Lecture), Joint Annual Convention of the Philippine Society of Gastroenterology, The Philippine Society of Digestive Endoscopy and Philippine Society of Hepatology, Manila, The Philippines, 12 March 2007. 2007. |
|
Poon R.T.P., Role of radiofrequency ablation for colorectal liver metastasis (Symposium Lecture), The 3rd International Colorectal Disease Symposium, Hong Kong, 25 - 26 January 2007. 2007. |
|
Poon R.T.P., Role of radiofrequency ablation in management of small hepatocellular carcinoma (Symposium Lecture), The 1st Biennial Congress of the Asian-Pacific Hepato-Pancreato-Biliary Association, Fukuoka, Japan, 20 - 23 March 2007. 2007. |
|
Poon R.T.P., Surgical management of hepatocellular carcinoma in Hong Kong (International Guest Scholarship Lecture), The 92nd Annual Clinical Congress of American College of Surgeons, Chicago, U.S.A., 8 - 12 October 2006. 2006. |
|
Poon R.T.P., Surgical treatments of hepatocellular carcinoma (Visiting Professor Lecture), Chongqing University of Medical Sciences, Chongqing, China, 14 September 2006. 2006. |
|
Poon
R.T.P., Surgical treatments of hepatocellular
carcinoma (Visiting Professor Lecture), The |
|
Poon R.T.P., The American College of Surgeons International Visiting Professor, The Indiana University, Indianapolis, USA, 12 - 15 October 2006. 2006. |
|
Poon R.T.P., The American College of Surgeons International Visiting Professor, Thomas Jefferson University, Philadelphia, USA, 15 - 18 October 2006. 2006. |
|
Poon
R.T.P., Traditional and evolving surgical
therapies for HCC (Symposium Lecture), The 2nd World Conference on
Interventional Oncology, |
|
Poon
R.T.P., Tutor, Preparatory Course for FRCS
Examination, The |
|
Poon
R.T.P., Vice-Chairman (2001 - present), Organizing
Committee, The 8th - 14th Hong Kong International Cancer Congress, |
|
Poon R.T.P., Visiting Professor, Chongqing University of Medical Sciences, Chongqing, China, 11 - 15 September 2006. 2006. |
|
Poon
R.T.P., Visiting Professor, Department of
Surgery, |
|
Poon R.T.P., Visiting Professor, Department of Surgery, Mayo Clinic, Rochester, USA, 10 - 14 May 2007. 2007. |
|
Poon R.T.P., Visiting Professor, Department of Surgery, Stanford University, USA, 28 April - 3 May 2007. 2007. |
|
Poon R.T.P., Visiting Professor, Department of Surgery, University of Toronto, Canada, 4 - 9 May 2007. 2007. |
|
Poon
R.T.P., Visiting Professor, Department of
Surgical Oncology, MD |
|
Poon R.T.P., Visiting Professor, Department of Surgical Oncology, MD Anderson Cancer Center, The University of Texas, USA, 10 - 14 January 2007. 2007. |
|
Poon
R.T.P., Visiting Professor, |
|
Poon
R.T.P., Visiting Professor, |
|
Sabherwal Y., Rothman V.L., Poon R.T.P. and Tuszynski G.P., Clinical significance of serum angiocidin levels in hepatocellular carcinoma, Cancer Letters. 2007, 251(1): 28-35. |
|
Shen Z., Yang Z., Gao Y., Poon R.T.P., Fan S.T., He M.L., Li T.P., Gan R.B., Kung H.F. and Lin M.C., Kringle 1 Domain of Human Hepatocyte Growth Factor (HGFK1) Inhibits the Growth and Metastasis of Hepatocellular Carcinoma in Rats, 10th Annual Meeting of the American Society of Gene Therapy, May 30-June 3, 2007, at the Washington State Convention and Trade Center in Seattle, WA. 2007. |
|
Sun
K.W., Man K., Liu C.L., Poon R.T.P. and Fan S.T., The significance of Pyk |
|
Tam
K.H., Yang Z. and Poon R.T.P., Inhibition of mTOR by
RAD001 enhances chemo-sensitivity of hepatocellular carcinoma (HCC) (Oral
Presentation), The 13th Hong Kong International Cancer Congress, |
|
Tam K.H., Yang Z. and Poon R.T.P., Young Investigator Award - "Inhibition of mTOR by RAD001 enhances chemo-sensitivity of hepatocellular carcinoma (HCC)", The 13th Hong Kong International Cancer Congress, Hong Kong, 15 - 17 August 2006. 2006. |
|
Wang X., Luk J.M.C., Garcia-Barcelo M.M., Miao X., Leung P.L., Ho D.W.Y., Cheung S.T., Lam B.Y.H., Cheung C.K.Y., Wong S.Y., Lau S.S.M., So M.T., Yu W.C., Cai Q., Liu K.S.Y., Hui C.K., Lau G., Poon R.T.P., Wong J. and Fan S.T., Liver intestine-cadherin (CDH17) haplotype is associated with increased risk of hepatocellular carcinoma, Clinical Cancer Research. 2006, 12(17): 5248-5252. |
|
Wong D.K.H., Yuen R.M.F., Poon R.T.P., Yuen J.C.H., Fung J.Y.Y. and Lai C.L., Quantification of hepatitis B virus covalently closed circular DNA in patients with hepatocellular carcinoma, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2006, 45: 553-559. |
|
Wong D.K.H., Yuen R.M.F., Poon R.T.P., Yuen J.C.H., Fung J.Y.Y. and Lai C.L., Quantitation of hepatitis B virus covalently closed circular DNA in patients with hepatocellular carcinoma, Journal of Hepatology. 2006, 45: 553-559. |
|
Wood B., Poon R.T.P., Neeman Z., Eugeni M., Locklin J., Dromi S., Kachala S., Probhakar R., Hahne W. and Libutti S.K., Phase I study of thermally sensitive liposomes containing doxorubicin (ThermoDox) given during radiofrequency ablation (RFA) in patients with unresectable hepatic malignancies (Abstract), Gastrointestinal Cancers Symposium, The American Society of Clinical Oncology, Orlando, USA, 19 - 21 January 2007. |
|
Yang Z., Ho D.W.Y., Ngai P.P., Lau C.K., Zhao Y., Poon R.T.P. and Fan S.T., Antiinflammatory properties of IL-10 rescue small-for-size liver grafts, Liver Transplantation. 2007, 13(4): 558-565. |
|
Yang Z., Poon R.T.P., Liu Y., Lau C.K., Ho D.W.Y., Tam K.H., Lam C.T. and Fan S.T., High doses of tyrosine kinase inhibitor PTK787 enhance the efficacy of ischemic hypoxia for the treatment of hepatocellular carcinoma: dual effects on cancer cell and angiogenesis, Molecular Cancer Therapeutics. 2006, 5(9): 2261-2270. |
|
Yang Z., Lau C.K., Ngai P.P., Ho D.W.Y., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Induction of long-term liver allograft survival by delayed immunosuppression is dependent on interleukin-10 (Oral Presentation), World Transplant Congress 2006, Boston, U.S.A., 22 - 27 July 2006. |
|
Yang Z., Ngai P.P., Lau C.K., Ho D.W.Y., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Induction of long-term liver allograft survival by delayed immunosuppression is dependent on interleukin-10, Liver Transplantation. 2007, 13(4): 571-578. |
|
Yang Z., Ho D.W.Y., Lau C.K., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Platelet activation during tumor development, the potential role of BDNF-TrkB autocrine loop, Biochemical and Biophysical Research Communications. 2006, 346(3): 981-985. |
|
Yang Z., Ho D.W.Y., Lau C.K., Tam K.H., Lam C.T., Yu W.C., Poon R.T.P. and Fan S.T., Significance of the serum brain-derived neurotrophic factor and platelets in hepatocellular carcinoma, Oncology Reports. 2006, 16(6): 1237-1243. |
|
Yuen R.M.F., Tanaka Y., Shinkai N., Poon R.T.P., But D.Y.K., Fong D.Y.T., Fung J.Y.Y., Wong D.K.H. and Yuen J.C.H., Risk for hepatocellular carcinoma with respect to hepatitis B virus genotypes B/ C, specific mutations of enhancer II/ core promoter/ precore regions and HBV DNA levels, Gut. 2007, Equb ahead of print. |
|
Yuen R.M.F., Tanaka Y., Shinkai N., Poon R.T.P., Fung J.Y.Y., Wong D.K.H., Yuen J.C.H., Mizokami M. and Lai C.L., Role of HBV genotypes, core promoter/precore mutations and HBV DNA levels on hepatocarcinogenesis, Annual meeting, European Association for the Study of Liver (EASL), Barcelona, Spain, 11 - 15 April 2007. |
|
Researcher
: Poon WS |
|
List of Research Outputs |
|
Ho J.C.Y., Cheung S.T., Poon W.S., Lee Y.T., Ng I.O.L. and Fan S.T., Down-regulation of retinol binding protein 5 is associated with aggressive tumor features in hepatocellular carcinoma, Journal of Cancer Research and Clinical Oncology. 2007. |
|
Researcher
: Ren Y |
|
Project Title: |
Proteomics computational analysis of Severe Acute Respiratory Syndrome |
|
Investigator(s): |
Ren Y, Tam PKH, Peiris JSM, He Q |
|
Department: |
Surgery |
|
Source(s) of Funding: |
VCO SARS Research Fund |
|
Start Date: |
07/2003 |
|
Abstract: |
|
To investigate by using proteomics approach, combining Western blotting and ELISA: (a) identification of specific pattern in serum for the diagnosis and prognosis, (b) detection of immune-relevant proteins in SARS, (c) detection of proteins in different stages of SARS patients, (d) proteome analysis of SCV (proteome maps), (e) detection of expression patterns in virus infected cells. |
|
List of Research Outputs |
|
Ren Y., Xie Y., Chan H.M. and Tam P.K.H., Visinin like protein 1 (VILIP-1) enhances neuroblastoma cell migration, 53rd Annual International Congress of the British Association of Paediatric Suregons, Stockholm, Sweden, 18-21 July 2006. |
|
Researcher
: Shao W |
|
List of Research Outputs |
|
Liu Y., Poon R.T.P., Shao W., Sun X., Chen H., Kok T.W. and Fan S.T., Blockage of epidermal growth factor receptor by quinazoline tyrosine kinase inhibitors suppresses growth of human hepatocellular carcinoma, Cancer Letters. 2007, 248(1): 32-40. |
|
Researcher
: Shih KC |
|
List of Research Outputs |
|
Shih K.C., Man K., Ng T.P., Xiao J., Fan S.T. and Lo C.M., Distinct gene signatures linked to acute phase injury and tumor invasiveness in tumor development after liver transplantation using small-for-size grafts (Abstract), The International Liver Transplantation Society 13th Annual International Congress, Rio de Janeiro, Brazil, 20 - 23 June 2007. |
|
Shih K.C., Man K., Ng T.P., Xiao J., Fan S.T. and Lo C.M., Rising Star Award - "Distinct gene signatures linked to acute phase injury and tumor invasiveness in tumor development after liver transplantation using small-for-size grafts", The International Liver Transplantation Society 13th Annual International Congress, Rio de Janeiro, Brazil, 20 - 23 June 2007. 2007. |
|
List of Research Outputs |
|
Gohel M.D.I., Shum K.Y. and Tam P.C., Electrophoretic separation and characterization of urinary glycosaminoglycans and their roles in urolithiasis, Carbohydrate Research. 2007, 342: 79-86. |
|
Luk J.M.C., Lee P.Y., Shum K.Y., Siu A.F.M., Che C.M., Tam P.C., Cheung A.N.Y., Yang Z.M., Lin Y.N., Matzuk M.M., Lee C.K.F. and Yeung W.S.B., Acrosome-Specific Gene AEP1: Identification, Characterization and Roles in Spermatogenesis , Journal of Cellular Physiology . 2006, 209: 755-766. |
|
Researcher
: Sit FYL |
|
List of Research Outputs |
|
Ngan
E.S.W., Lee K.Y., Sit F.Y.L., Chan J.K.Y., Sham M.H., Lui V.C.H. and Tam P.K.H., Roles of Prokineticin |
|
Researcher
: Sit YLF |
|
List of Research Outputs |
|
Ngan E.S.W., Sit Y.L.F., Lee K.Y., Miao X., Yuan Z., Wang W.L., Nicholls J.M., Wong K.K.Y., Garcia-Barcelo M.M., Lui V.C.H. and Tam P.K.H., Implications of endocrine gland - derived vascular endothelial growth factor/prokineticin-1 signaling in human neuroblastoma progression., Clinical Cancer Research. 2007, 13(3): 868-875. |
|
Ngan E.S.W., Lee K.Y., Sit Y.L.F., Poon H.C., Chan J.K.Y., Sham M.H., Lui V.C.H. and Tam P.K.H., Prokineticin-1 modulates proliferation and differentiation of enteric neural crest cells, Biochimica et Biophysica Acta. 2007, 1773(4): 536-545. |
|
List of Research Outputs |
|
Tsui T.Y., Obed A., Siu Y.T., Yet S.F., Prantl L., Schlitt H.J. and Fan S.T., Carbon monoxide inhalation rescues mice from fulminant hepatitis through improving hepatic energy metabolism, Shock. 2007, 27(2): 165-171. |
|
Researcher
: So MT |
|
List of Research Outputs |
|
Fong P.Y., Garcia-Barcelo M.M., Sham P.C., Ng P.K.M., Lau C.F., So M.T., Mak W.W. and Tam P.K.H., Genetic mapping for RET-dependent modifiers in Hirschsprung disease (HSCR), 56th Annual Meeting of the American Society of Human Genetics, New Orleans, U.S.A., 9-13 October 2006. |
|
Garcia-Barcelo M.M., King S.K., Miao X., So M.T., Holden W.T., Moore J.H., Sutcliffe J.R., Hutson J.M. and Tam P.K.H., Application of HapMap data to the evaluation of 8 candidate genes for pediatric slow transit constipation, Journal of Pediatric Surgery. 2007, 42(4): 666-671. |
|
Garcia-Barcelo M.M., Miao X., Lui V.C.H., So M.T., Ngan E.S.W., Leon T.Y., Lau D.K., Liu T.T., Lao X., Guo W., Holden W.T., Moore J. and Tam P.K.H., Correlation between genetic variations in Hox clusters and Hirschsrpung's disease, Annals of Human Genetics. 2007, 71(Pt 4): 526-536. |
|
Miao X., Garcia-Barcelo M.M., So M.T., Leon Y.Y., Lau K.C., Liu T., Chan E.K.W., Lan L.C.L., Wong K.K.Y., Lui V.C.H. and Tam P.K.H., Role of RET and PHOX2B gene polymorphisms in risk of Hirschsprung's disease in Chinese population, Gut. 2007, 56(5): 736. |
|
Wang X., Luk J.M.C., Garcia-Barcelo M.M., Miao X., Leung P.L., Ho D.W.Y., Cheung S.T., Lam B.Y.H., Cheung C.K.Y., Wong S.Y., Lau S.S.M., So M.T., Yu W.C., Cai Q., Liu K.S.Y., Hui C.K., Lau G., Poon R.T.P., Wong J. and Fan S.T., Liver intestine-cadherin (CDH17) haplotype is associated with increased risk of hepatocellular carcinoma, Clinical Cancer Research. 2006, 12(17): 5248-5252. |
|
Researcher
: Suen DTK |
|
List of Research Outputs |
|
Chok S.H., Suen D.T.K. and Kwong A., Factors affecting false-negative rates of sentinel lymph node biopsy in breast cancer (Abstrat 04-06), Surgical Practice. 2006, 10 Suppl. |
|
Chok S.H., Suen D.T.K. and Kwong A., Factors affecting false-negative rates of sentinel lymph node biopsy in breast cancer (Oral), Royal College of Surgeons of Edinburgh, College of Surgeons of Hong Kong Conjoint Scientific Congress, Hong Kong, 10 - 13 October 2006. |
|
Kwong A. and Suen D.T.K., Breast conserving surgery in Hong Kong Chinese women (Poster), American Society of Breast Disease, San Francesco, U.S.A, 12 - 14 April 2007. |
|
Kwong A., Suen D.T.K. and Cheung T.T., The experience of senitnel lymph node biopsy in Chinese breast cancer patients with prior neo-adjuvant chemotherapy (Poster), St. Gallen Breast Conference, Switzerland, 13 - 18 March 2007. |
|
Kwong A., Suen D.T.K. and Cheung T.T., The experience of sentinel lymph node biopsy in Chinese breast cancer patients with prior neo-adjuvant chemotherapy (Abstract S51), The Breast. 2007, 16, Suppl 1. |
|
Kwong A., Suen D.T.K. and Cheung T.T., The experience of sentinel lymph node biopsy in Chinease breast cancer patients with prior neo-adjuvant chemotherapy (Abstract), St. Gallen Breast Conference, Switzerland, 14 - 17 March 2007. |
|
Suen
D.T.K. and Kwong
A., Breast conserving surgery after neoadjuvant therapy in Chinese breast
cancer patients (Poster), NCBC Conference, |
|
Suen D.T.K. and Kwong A., Breast conserving surgery in Hong Kong Chinese women (Oral), Royal College of Surgeons of Edinburgh, College of Surgeons of Hong Kong Conjoint Scientific Congress, Hong Kong, 10 - 13 October 2006. |
|
Suen D.T.K. and Kwong A., Breast conserving surgeyr in Hong Kong Chinese women (Abstract 04-04), Surgical Practice. 2006, 10 Suppl. |
|
Suen
D.T.K. and Kwong
A., Factors affecting false-negative rates of sentinel lymph node biopsy
in breast cancer (Poster), American Society of Breast Disease, |
|
Suen
D.T.K. and Kwong
A., Response to neoadjuvant chemotherapy and hormonotherapy in Chinese
women with breast cancer (Poster), NCBC Conference, |
|
Suen
D.T.K. and Kwong
A., Response to neoadjuvant chemotherapy and hormonotherapy in Chinese
women with breast cancer, NCBC Conference, |
|
Suen
D.T.K. and Kwong
A., The experience of sentinel lymph node biopsy in breast cancer patient
with prior neo-adjuvant chemotherapy (Poster), American Society of Breast |
|
Suen
D.T.K., Cheung T.T. and Kwong A., The experience of sentinel
lymph node biopsy in breast cancer patients with pior neo-adjuvant
chemotherapy (Oral), |
|
Suen D.T.K., Cheung T.T. and Kwong A., The experience of sentinel lymph node biopsy in breast cancer patients with prior neo-adjuvant chemotherapy (Abstract 04-07), Surgical Practice. 2006, 10 Suppl. |
|
Researcher
: Sun B |
|
List of Research Outputs |
|
Man K., Xiao J., Ng T.P., Cheng Q., Sun B., Wang Y., Sun K.W., Poon R.T.P. and Lo C.M., Adiponectin as a novel therapy for the suppression of the liver cancer growth and metastasis (Paper Presentation), the 14th European Organisation for the Research and Treatment of Cancer, National Cancer Institute, and American Association for Cancer Research (EORTC-NCI-AARC) Symposium on Molecular Targets and Cancer Therapeutics, Prague, Czech Republic, 7 - 10 November 2006. European Journal of Cancer Supplement. 2006, 50. |
|
Man K., Ng T.P., Xu A.M., Cheng Q., Sun B., Sun K.W., Lee K.W., Lo C.M., Poon R.T.P. and Fan S.T., Fat-derived hormone adiponectin suppresses liver tumor growth and metastases (Paper Presentation), The 98th Annual Meeting of the American Association for Cancer Research, Los Angeles, USA, 14 - 18 April 2007. |
|
Ng T.P., Man K., Cheng Q., Sun B., Lee K.W., Poon R.T.P., Lo C.M. and Fan S.T., Suppression of tumorigenesis and metastasis of hepatocellular of hepatocellular carcinoma by shRNA interference targeting on inhibition of homeoprotein Six1 (Paper Presentation), The 98th Annual Meeting of the American Association for Cancer Research, Los Angeles, USA, 14 - 18 April 2007. |
|
Researcher
: Sun KW |
|
List of Research Outputs |
|
Ho J.W.Y., Pang R.W.C., Lau C.P.Y., Sun K.W., Yu W.C., Fan S.T. and Poon R.T.P., Significance of circulating endothelial progenitor cells in hepatocellular carcinoma, Hepatology. 2006, 44(4): 836-843. |
|
Man K., Xiao J., Ng T.P., Cheng Q., Sun B., Wang Y., Sun K.W., Poon R.T.P. and Lo C.M., Adiponectin as a novel therapy for the suppression of the liver cancer growth and metastasis (Paper Presentation), the 14th European Organisation for the Research and Treatment of Cancer, National Cancer Institute, and American Association for Cancer Research (EORTC-NCI-AARC) Symposium on Molecular Targets and Cancer Therapeutics, Prague, Czech Republic, 7 - 10 November 2006. European Journal of Cancer Supplement. 2006, 50. |
|
Man K., Xiao J., Ng T.P., Cheng Q., Sun K.W., Lo C.M., Poon R.T.P. and Fan S.T., Combination therapy for liver tumor growth and metastasis by low dose rapamycin and FTY720 (Paper Presentation), the 14th European Organisation for the Research and Treatment of Cancer, National Cancer Institute, and American Association for Cancer Research (EORTC-NCI-AARC) Symposium on Molecular Targets and Cancer Therapeutics, Prague, Czech Republic, 7 - 10 November 2006. |
|
Man K., Ng T.P., Xu A.M., Cheng Q., Sun B., Sun K.W., Lee K.W., Lo C.M., Poon R.T.P. and Fan S.T., Fat-derived hormone adiponectin suppresses liver tumor growth and metastases (Paper Presentation), The 98th Annual Meeting of the American Association for Cancer Research, Los Angeles, USA, 14 - 18 April 2007. |
|
Man K., Lo C.M., Ng T.P., Sun S., Sun K.W. and Fan S.T., Significant correlation between intragraft gene expression profiles linking to acute phase injury and angoneness with HCC recurrence after LDLT (Plenary Lecture), The International Liver Transplantation Society 13th Annual International Congress, Rio de Janeiro, Brazil, 20 - 23 June 2007. 2007. |
|
Man K., Lo C.M., Xiao J., Ng T.P., Sun K.W., Wang Y. and Fan S.T., The significance of acute phase graft injury on tumor recurrence/metastases in live donor liver transplantation (Abstract), World Transplant Congress 2006, Boston, U.S.A., 22 -27 July 2006. |
|
Man K., Lo C.M., Xiao J., Ng T.P., Sun K.W., Wang Y. and Fan S.T., The significance of graft size on tumor recurrence after liver transplantation - activation of cell invasion pathway (Abstract), World Transplant Congress 2006, Boston, U.S.A., 22 - 27 July 2006. |
|
Ng
T.P., Man K., Sun K.W., Lee K.W., Poon R.T.P., Lo C.M. and Fan S.T., Clinicopathological
significance of homeoprotein Six |
|
Ng
T.P., Man K., Ho J.W.Y., Sun K.W., Lee K.W., Zhao Y., Lo C.M., Poon R.T.P. and Fan S.T., Marked suppression of tumor
growth by FTY |
|
Sun
K.W., Man
K., Liu C.L., Poon R.T.P. and Fan S.T., The significance of Pyk |
|
Researcher
: Sun S |
|
List of Research Outputs |
|
Man K., Lo C.M., Ng T.P., Sun S., Sun K.W. and Fan S.T., Significant correlation between intragraft gene expression profiles linking to acute phase injury and angoneness with HCC recurrence after LDLT (Plenary Lecture), The International Liver Transplantation Society 13th Annual International Congress, Rio de Janeiro, Brazil, 20 - 23 June 2007. 2007. |
|
Researcher
: Tam KH |
|
List of Research Outputs |
|
Ho
D.W.Y., Yang Z., Lau C.K., Tam K.H., To J.Y.T., Poon R.T.P. and Fan S.T., Therapeutic potential of
cardiotrophin |
|
Poon R.T.P., Tam K.H., Yang Z. and Fan S.T., Both p53 dependent and independent pathways contribute to RAD001 mediated enhancement of chemo-sensitivity in hepatocellular carcinoma (Poster Presentation), The 98th Annual Meeting of the American Association for Cancer Research, Los Angeles, USA, 14 - 18 April 2007. |
|
Tam
K.H., Yang
Z. and Poon R.T.P., Inhibition of
mTOR by RAD001 enhances chemo-sensitivity of hepatocellular carcinoma (HCC)
(Oral Presentation), The 13th Hong Kong International Cancer Congress, |
|
Tam K.H., Targeting mTOR as a novel therapeutic strategy for
hepatocellular carcinoma, Thesis, Master of Philosophy, The |
|
Tam K.H., Yang Z. and Poon R.T.P., Young Investigator Award - "Inhibition of mTOR by RAD001 enhances chemo-sensitivity of hepatocellular carcinoma (HCC)", The 13th Hong Kong International Cancer Congress, Hong Kong, 15 - 17 August 2006. 2006. |
|
Tam K.H., Young Investigator Award - mTOR inhibition enhances chemosensitivity of hepatocellular carcinoma, The 13th Hong Kong International Cancer Congress, Hong Kong, 15 - 17 November 2006. 2006. |
|
Yang Z., Poon R.T.P., Liu Y., Lau C.K., Ho D.W.Y., Tam K.H., Lam C.T. and Fan S.T., High doses of tyrosine kinase inhibitor PTK787 enhance the efficacy of ischemic hypoxia for the treatment of hepatocellular carcinoma: dual effects on cancer cell and angiogenesis, Molecular Cancer Therapeutics. 2006, 5(9): 2261-2270. |
|
Yang Z., Lau C.K., Ngai P.P., Ho D.W.Y., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Induction of long-term liver allograft survival by delayed immunosuppression is dependent on interleukin-10 (Oral Presentation), World Transplant Congress 2006, Boston, U.S.A., 22 - 27 July 2006. |
|
Yang Z., Ngai P.P., Lau C.K., Ho D.W.Y., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Induction of long-term liver allograft survival by delayed immunosuppression is dependent on interleukin-10, Liver Transplantation. 2007, 13(4): 571-578. |
|
Yang Z., Ho D.W.Y., Lau C.K., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Platelet activation during tumor development, the potential role of BDNF-TrkB autocrine loop, Biochemical and Biophysical Research Communications. 2006, 346(3): 981-985. |
|
Yang Z., Ho D.W.Y., Lau C.K., Tam K.H., Lam C.T., Yu W.C., Poon R.T.P. and Fan S.T., Significance of the serum brain-derived neurotrophic factor and platelets in hepatocellular carcinoma, Oncology Reports. 2006, 16(6): 1237-1243. |
|
Researcher
: Tam KH |
|
List of Research Outputs |
|
Ho
D.W.Y., Yang Z., Lau C.K., Tam K.H., To J.Y.T., Poon R.T.P. and Fan S.T., Therapeutic potential of
cardiotrophin |
|
Poon R.T.P., Tam K.H., Yang Z. and Fan S.T., Both p53 dependent and independent pathways contribute to RAD001 mediated enhancement of chemo-sensitivity in hepatocellular carcinoma (Poster Presentation), The 98th Annual Meeting of the American Association for Cancer Research, Los Angeles, USA, 14 - 18 April 2007. |
|
Tam
K.H., Yang
Z. and Poon R.T.P., Inhibition of
mTOR by RAD001 enhances chemo-sensitivity of hepatocellular carcinoma (HCC)
(Oral Presentation), The 13th Hong Kong International Cancer Congress, |
|
Tam K.H., Targeting mTOR as a novel therapeutic strategy for
hepatocellular carcinoma, Thesis, Master of Philosophy, The |
|
Tam K.H., Yang Z. and Poon R.T.P., Young Investigator Award - "Inhibition of mTOR by RAD001 enhances chemo-sensitivity of hepatocellular carcinoma (HCC)", The 13th Hong Kong International Cancer Congress, Hong Kong, 15 - 17 August 2006. 2006. |
|
Tam K.H., Young Investigator Award - mTOR inhibition enhances chemosensitivity of hepatocellular carcinoma, The 13th Hong Kong International Cancer Congress, Hong Kong, 15 - 17 November 2006. 2006. |
|
Yang Z., Poon R.T.P., Liu Y., Lau C.K., Ho D.W.Y., Tam K.H., Lam C.T. and Fan S.T., High doses of tyrosine kinase inhibitor PTK787 enhance the efficacy of ischemic hypoxia for the treatment of hepatocellular carcinoma: dual effects on cancer cell and angiogenesis, Molecular Cancer Therapeutics. 2006, 5(9): 2261-2270. |
|
Yang Z., Lau C.K., Ngai P.P., Ho D.W.Y., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Induction of long-term liver allograft survival by delayed immunosuppression is dependent on interleukin-10 (Oral Presentation), World Transplant Congress 2006, Boston, U.S.A., 22 - 27 July 2006. |
|
Yang Z., Ngai P.P., Lau C.K., Ho D.W.Y., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Induction of long-term liver allograft survival by delayed immunosuppression is dependent on interleukin-10, Liver Transplantation. 2007, 13(4): 571-578. |
|
Yang Z., Ho D.W.Y., Lau C.K., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Platelet activation during tumor development, the potential role of BDNF-TrkB autocrine loop, Biochemical and Biophysical Research Communications. 2006, 346(3): 981-985. |
|
Yang Z., Ho D.W.Y., Lau C.K., Tam K.H., Lam C.T., Yu W.C., Poon R.T.P. and Fan S.T., Significance of the serum brain-derived neurotrophic factor and platelets in hepatocellular carcinoma, Oncology Reports. 2006, 16(6): 1237-1243. |
|
Researcher
: Tam PC |
|
List of Research Outputs |
|
|
|
Gohel M.D.I., Shum K.Y. and Tam P.C., Electrophoretic separation and characterization of urinary glycosaminoglycans and their roles in urolithiasis, Carbohydrate Research. 2007, 342: 79-86. |
|
Ho K.L., Ma K.K., Au W.H., Chu S.S.M. and Tam P.C., Improving prostate cancer detection with an extended 10-core transrectal ultrasound-guided prostate biopsy protocol in a local Chinese population, 12th Annual Scientific Meeting, Hong Kong Urological Association, Hong Kong, 5 November 2006. |
|
Ho K.L., Chu S.S.M. and Tam P.C., Laparoscopic partial nephrectomy: evaluation of early experience and comparison with open partial nephrectomy, Surgical Practice. 2006, 10 (Suppl.): A29. |
|
Lee P.Y., Leung K.W., Wo J.Y., Tam P.C., Yeung W.S.B. and Luk J.M.C., Blockage of testicular connexins induced apoptosis in rat seminiferous spithelium, Apoptosis. 2006, 11: 1215-1229. |
|
Luk J.M.C., Lee P.Y., Shum K.Y., Siu A.F.M., Che C.M., Tam P.C., Cheung A.N.Y., Yang Z.M., Lin Y.N., Matzuk M.M., Lee C.K.F. and Yeung W.S.B., Acrosome-Specific Gene AEP1: Identification, Characterization and Roles in Spermatogenesis , Journal of Cellular Physiology . 2006, 209: 755-766. |
|
Ma K.K., Ho K.L., Chu S.S.M. and Tam P.C., Percutaneous BioGlue injection in treatment of persistent nephroncutaneous fistula after partial nephrectomy, 12th Annual Scientific Meeting, Hong Kong Urological Association, Hong Kong, 5 November 2006. 47. |
|
Ng E.H.Y., Tam P.C., Yeung W.S.B. and Ho P.C., Management of male subfertility, Journal of Paediatrics, Obstetrics and Gynaecology. 2007, Jan/Feb 2007: 37-43. |
|
Tai C.K., Ho K.L., Ma K.K., Au W.H., Chu S.S.M. and Tam P.C., Percent free prostate-specific antigen improves specificity of prostate cancer detection in patients with elevated prostate-specific antigen 4-20ng/ml and non-suspicious digital rectal examination, 12th Annual Scientific Meeting, Hong Kong Urological Association, Hong Kong, 5 November 2006. |
|
Tam
P.C., Chairman, CMC Committee, The |
|
Tam
P.C., Chairman, Urology Board, The |
|
Tam P.C., Council Member (2004 - present), Asia Pacific Society of Sexual Medicine. 2007. |
|
Tam P.C., Council Member (2005 - present), The College of Surgeons of Hong Kong. 2007. |
|
Tam P.C., Deputy Secretary General (1996 - present), Asian Surgical Association. 2007. |
|
Tam P.C., Examiner in Conjoint Urology Fellowship Examination, College of Surgeons of Hong Kong & Royal College of Surgeons of Edinburgh. 2007. |
|
Tam P.C., Honorary Consultant (1996 - present), Sexual Rehabilitation Service ReHaAid. 2007. |
|
Tam P.C., Honorary Consultant (Urology) (1998 - present), Tung Wah Hospital. 2007. |
|
Tam P.C., Member (1990 - present), Central Renal Committee, Hospital Authority (Formerly Hospital Service Department). 2007. |
|
Tam
P.C., Member (2000 - present), Working
Group on Male Sexual and Reproductive Health, The Family Planning Association
of |
|
Tam P.C., Member of Editorial Board (2005 - present), Hong Kong Medical Journal. 2007. |
|
Tam
P.C., |
|
Tam P.C., Wong S.C.W., Ho K.L. and Ng E.H.Y., Serum FSH as predictive factor for successful sperm recovery in non-obstructive azoospermic patients (Poster Presentation), Annual Meeting of the American Urological Association, Anaheim, U.S.A., 23 May 2007. |
|
Tam P.C., Wong S.C.W., Ho K.L. and Ng E.H.Y., Serum FSH as predictive factor for successful sperm recovery in non-obstructive azoospermic patients, The Journal of Urology. 2007, 177(4) (Suppl.): 645. |
|
Tam P.C., Vice-Chairman (2003 - present), Specialty Group in Urology Service, Hospital Authority. 2007. |
|
Tam P.C., Visiting Urologist (1992 - present), MacLehose Medical Rehabilitatio Centre. 2007. |
|
Researcher
: Tam PKH |
|
Project Title: |
Transgenesis animals as bioreactors: production of a new immunosuppressive protein CTLA4Ig by transgenesis |
|
Investigator(s): |
Tam PKH, Wong NS, Cheah KSE |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Vice-Chancellor's Office - General Award |
|
Start Date: |
07/1997 |
|
Abstract: |
|
The use of transgenic farm animals as bioreactors is a potentially powerful and important new industry for the next century. This application of transgenic technology, in combination with the recent advance in ability to clone animals from adult cells, enhances the potential of transgenic animal bioreactors as major producers of therapeutic proteins. Therefore by initiating research in this area there are immediate and long-term benefits to Hong Kong and China. |
|
Project Title: |
Establishing a "train-the-trainers" programme for paediatric surgery in China |
|
Investigator(s): |
Tam PKH, Lin CL |
|
Department: |
Surgery |
|
Source(s) of Funding: |
S.K. Yee Medical Foundation - General Award |
|
Start Date: |
10/1998 |
|
Abstract: |
|
To improve the standard of surgical care of children in China through the establishment of a scheme of "train-the-trainers"; to improve our understanding of special paediatric surgical issues relevant to the Chinese population (e.g. disease patterns, transferability of western "advances" to China etc.) through systematic exchanges with major centres in China and hence enhance our ability to deliver better surgical care to children in Hong Kong. |
|
Project Title: |
Expanding the "Train-the-Trainers" programme for paediatric surgery in China |
|
Investigator(s): |
Tam PKH, Lin CL |
|
Department: |
Surgery |
|
Source(s) of Funding: |
S.K. Yee Medical Foundation - General Award |
|
Start Date: |
10/2000 |
|
Abstract: |
|
To improve the standard of surgical care of children in China through the consolidation and expansion of a scheme of "Train-the-Trainers"; to improve our understanding of special paediatric surgical issues relevant to the Chinese population (e.g. disease patterns, transferability of western "advances" to China etc) through systematic exchanges with major centres in China and hence enhance our ability to deliver better surgical care to children in Hong Kong; to promote modern concepts of medical education among leaders of the new generation of doctors through the introduction of structured training, problem-based learning, life-long learning, and the use of evidence-based medicine and information technology. |
|
Project Title: |
The role of sonic hedgehog in immune system |
|
Investigator(s): |
Tam PKH, Lin CL |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
10/2002 |
|
Abstract: |
|
To elucidate the role of sonic hedgehog in CD4+ T cells activation and to identify its downstream targets suring T cell activation. |
|
Project Title: |
Improving the survival and quality of life of children with cancers in China |
|
Investigator(s): |
Tam PKH, Wong IHN, Chan GCF, Ren Y, Lin CL |
|
Department: |
Surgery |
|
Source(s) of Funding: |
S.K. Yee Medical Foundation - General Award |
|
Start Date: |
10/2003 |
|
Abstract: |
|
To improve the survival and quality of life of poor and sick children suffering from cancer through the establishment of a Chinese Children Cancer Consortium which will be responsible for the introduction and implementation of modern, comprehensive management protocols, and for training and educating health care workers around the country to adopt the new standard of cares for children with cancer. |
|
Project Title: |
The study of co-stimulatory function of sonic hedgehog in CD4+ lymphocytes |
|
Investigator(s): |
Tam PKH, Chan VSF |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2003 |
|
Abstract: |
|
To study the distribution of Shh and its receptors on the surface of T cells during T cell activation; to study the effect of Shh on TH1 and TH2 cell differentiation; to identify the downstream targets of Shh signaling pathway in CD4+ T lymphocytes. |
|
Project Title: |
Evaluation of HOXB5 as a new Hirschprung's disease susceptibility locus |
|
Investigator(s): |
Tam PKH, Lui VCH, Garcia-Barcelo MM |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2004 |
|
Abstract: |
|
To evaluate the human HOXB5 gene as a new Hirschsprung's disease susceptibility locus. |
|
Project Title: |
Further expansion of the "Train-the-Trainers" programme for paediatric surgery in China |
|
Investigator(s): |
Tam PKH, Chan KL, Zhan JH |
|
Department: |
Surgery |
|
Source(s) of Funding: |
S.K. Yee Medical Foundation - General Award |
|
Start Date: |
05/2005 |
|
Abstract: |
|
The project aims to improve the standard of surgical care of children in China; to improve understanding of special paediatric surgical issues relevant to the Chinese population; and to promote modern concepts of medical education among leaders of the new generation of doctors in China. |
|
Project Title: |
University strategic research theme: Genomics, Proteomics & Bioinformatics |
|
Investigator(s): |
Tam PKH, Leung FCC, Chen SF, Che CM, He Q, Ng KP |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Seed Funding for Strategic Research Theme |
|
Start Date: |
05/2005 |
|
Abstract: |
|
To facilitate multidisciplinary research in the areas of genomics, proteomics and bioinformatics. The three subthemes would be created, and an additional subtheme on thical, legal and social issues (ELSI) should be created. |
|
Project Title: |
Molecular basis of biliary atresia |
|
Investigator(s): |
Tam PKH, Garcia-Barcelo MM, Miao X |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
07/2006 |
|
Abstract: |
|
Objective: To evaluate the human INV,
CFC1, ZIC3, HES, JAGGED1 and NOTCH genes for the presence of coding region
mutations in patients affected with biliary atresia (BA). Problems being
adressed: There is a need to clarify the involvement of these genes in the
defective morphogenesis of the bile-ducts to assess their role in the genetic
network underlying biliary atresia (BA). Therefore, we propose to conduct a
large-scale mutation screening of these genes in BA patients. We will also
perform functional analysis of the mutations found. This study will be
conducted on 150 BA patients of Chinese origin and will be the first study ever
conducted on Chinese at such relatively large scale.Background and key
isuesExtrahepatic Biliary Atresia (BA) is the cause of neonatal cholestasis
(arrest of the normal flow of bile) and defines the inflammatory obliteration
of the extrahepatic biliary system. The incidence of the disease ranges from
approximately |
|
Project Title: |
Study of the genetic basis of biliary atresia |
|
Investigator(s): |
Tam PKH, Garcia-Barcelo MM, Miao X, Sham PC |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2007 |
|
Abstract: |
|
(1) To conduct a whole-genome case-control association study for genes involved in BA by using GeneChip Mapping 500K Set from Affymetrix and will approximately gather clinical data and DNA from 200 BA patients of Chinese origin; (2) to generate information on: a) the genetic susceptibility to develop BA: b) the genetic predisposition to develop secondary biliary cirrhosis after surgery, thought to be an autoimmune process; c) yet unknown genetic causes that may trigger the disease. |
|
Project Title: |
Whole genome family based association study to search for RET-dependent modifiers in Hirchsprung's disease |
|
Investigator(s): |
Tam PKH, Garcia-Barcelo MM, Miao X, Cherny SS |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
05/2007 |
|
Abstract: |
|
Hirschsprung's disease (HSCR) is a
congenital disorder in which there is an absence of ganglion cells in
variable portions of the lower digestive tract. Its incidence varies among
populations, being more frequent in Asians. HSCR patients can be classified
according to the severity of the phenotype into long (L-SHCR) and short
(S-HSCR) segment-aganglionosis. HSCR presents mostly sporadically although it
can be familial with a complex pattern of inheritance including low,
sex-dependent penetrance and phenotypic variability. The male:female ratio
(M:F) is ≈4:1 among S-HSCR patients and ≈1:1 among L-HSCR patients(1). The RET gene, encoding a
tyrosine-kinase receptor is the major HSCR gene and its expression is crucial
for the development of the enteric ganglia. Reduced penetrance of RET
mutations and variable expression of HSCR phenotype suggest that more than
one gene is required. Current data indicates that S-HSCR manifestation always
requires RET (major gene) and other interacting susceptibility alleles(2).
While the pattern of inheritance of L-HSCR can be more easily explained by
combining the nature of the RET mutations and the effect of a stronger
modifier(3), that of S-HSCR is considerably more complex requiring RET and
several other loci, possibly RET-dependent modifiers(2). HSCR is as an
oligogenic entity currently being genetically dissected and used as a
paradigm for the study of polygenic/complex diseases(2;4). Yet, further
insight into the genes governing S-HSCR in particular is to be gained in
order to explain the transmission of S-HSCR, and other particulars such as
gender bias. The basic premise is that common genetic variants are involved
in the manifestation of the HSCR phenotype which in turn may also depend on
the RET mutational type of the patients. Finding additional HSCR loci
requires a large-scale SNP analyses on a collection of patients with well
defined phenotypes/RET genotypes. The need for such studies has also been
raised by the International HSCR Consortium of which we are not only active
participants but the only source of samples from patients of Chinese origin.
Along with the consortium, we have conducted a Transmission Disequilibrium
Test (TDT) as a family association study on 72 S-HSCR trios using 250.000
SNPs (36 trios have already been interrogated for the 262,000 SNPs comprised
on the array using Nsp restriction enzyme and the other 36 are currently
being done for the 238,000 SNPs on the Sty array). We believe that increasing
the density of the SNPs of this pilot study (TDT) will provide us with a much
more robust set of data to build on. Therefore, we are proposing to complete
the analysis of the 72 trios with the complete 500K set (each trio to be
interrogated for 500,000 SNPs; that is with both SNP arrays). Our data will
be compared to that obtained in a complementary study conducted on the
Caucasian consortium S-HSCR trios. This will help elucidate whether RET
modifiers modulating the phenotype are shared among populations.REFERENCES:1.
Amiel J, Lyonnet S 2001 Hirschsprung disease, associated syndromes, and
genetics: a review. J Med Genet 38:729-7392. Gabriel SB, Salomon R, Pelet A,
Angrist M, Amiel J, Fornage M, Attie-Bitach T, Olson JM, Hofstra R, Buys C,
Steffann J, Munnich A, Lyonnet S, Chakravarti A 2002 Segregation at three
loci explains familial and population risk in Hirschsprung disease. Nat Genet
31:89-933. Bolk S, Pelet A, Hofstra RM, Angrist M, Salomon R, Croaker D, Buys
CH, Lyonnet S, Chakravarti A |
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List of Research Outputs |
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Abecasis G., Tam P.K.H., Bustamante C.D., Ostrander E.A., Scherer S.W., Chanock S.J., Kwok P.Y. and Brookes A.J., Human Genome Variation 2006: emerging views on structural variation and large-scale SNP analysis, Nature Genetics. 2007, 39(2): 153-155. |
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Chan D.T.I., Wong K.K.Y. and Tam P.K.H., Spontaneous pneumoperitoneum after pneumonia in a child., Journal of Paediatrics and Child Health. 2007, 43(1): 85-86. |
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Chan H.Y., Wong K.K.Y., Lan L.C.L. and Tam P.K.H., The use of MRI in helping sex determination decision making for intersex patients, The 40th Annual Meeting of the Pacific Association of Paediatric Surgeons together with the Annual Scientific Meeting of the Australasian Association of Paediatric Surgeons, Queenstown, New Zealand, 15-19 April 2007. |
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Chan K.L., Chan H.Y. and Tam P.K.H., Towards zero recurrence rate in laparoscopic inguinal hernia repair for paediatric patients of all ages, The 40th Annual Meeting of the Pacific Association of Paediatric Surgeons together with the Annual Scientific Meeting of the Australasian Association of Paediatric Surgeons, Queenstown, New Zealand, 15-19 April 2007. |
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Chan V.S.F., Chau S.Y., Tian L., Chen Y., Kwong S.K.Y., Quackenbush J., Dallman M., Lamb J. and Tam P.K.H., Sonic hedgehog promotes CD4+ T lymphocyte proliferation and modulates the expression of a subset of CD28-targeted genes, International Immunology. 2006, 18(12): 1627-1636. |
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Chen Y., Li X., Tian L., Lui V.C.H., Dallman M.J., Lamb J.R. and Tam P.K.H., Inhibition of sonic hedgehog signaling reduces chronic rejection and prolongs allograft survival in a rat orthotopic small bowel transplantation model, Transplantation. 2007, 83(10): 1351-1357. |
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Chen Y., Liu Y., Yuan Z., Tian L., Dallman M.J., Thompson P.W., Tam P.K.H. and Lamb J.R., Rosiglitazone suppresses cyclosporin-induced chronic transplant dysfunction and prolongs survival of rat cardiac allografts, Transplantation. 2007, 83(12): 1602-1610. |
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Chen Y., Kam C.S.K., Lui V.C.H. and Tam P.K.H., TGF-B blockade aggravates gut ischemia reperfusion injury via activation of resident macrophages, 53rd Annual International Congress of the British Association of Paediatric Surgeons, Stockholm, Sweden, 18-21 July 2006. |
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Fong P.Y., Garcia-Barcelo M.M., Sham P.C., Ng P.K.M., Lau C.F., So M.T., Mak W.W. and Tam P.K.H., Genetic mapping for RET-dependent modifiers in Hirschsprung disease (HSCR), 56th Annual Meeting of the American Society of Human Genetics, New Orleans, U.S.A., 9-13 October 2006. |
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Garcia-Barcelo M.M., King S.K., Miao X., So M.T., Holden W.T., Moore J.H., Sutcliffe J.R., Hutson J.M. and Tam P.K.H., Application of HapMap data to the evaluation of 8 candidate genes for pediatric slow transit constipation, Journal of Pediatric Surgery. 2007, 42(4): 666-671. |
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Garcia-Barcelo M.M., Miao X., Lui V.C.H., So M.T., Ngan E.S.W., Leon T.Y., Lau D.K., Liu T.T., Lao X., Guo W., Holden W.T., Moore J. and Tam P.K.H., Correlation between genetic variations in Hox clusters and Hirschsrpung's disease, Annals of Human Genetics. 2007, 71(Pt 4): 526-536. |
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Garcia-Barcelo M.M., Amiel J., Antinolo G., Borrego S., Burzynski G., Ceccherini I., Emison E., Eng C., Fernandez R., Griseri P., Hofstra R., Kashuk C., Lantien F., Lyonnet S., Miao X., Tam P.K.H., Tullio-Pelet A., West K. and Chakravarti A., Higher prevalence of Hirschsprung disease in China explained by a common RET mutation, 56th Annual Meeting of the American Society of Human Genetics, New Orleans, U.S.A., 9-13 October 2006. |
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Lau C.K., Yang Z., Lam C.T., Tam P.K.H., Poon R.T.P. and Fan S.T., Suppression of hypoxia inducible factor-1a (HIF-1a) by YC-1 is dependent on murine double minute 2 (MDM2), Biochemical and Biophysical Research Communications. 2006, 348(4): 1443-1448. |
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Liu C., Cheung K., Cheng Y.C., Tilton R., Rong J., Ng K.M., Lau A.S.Y. and Tam P.K.H., An Ontology of Minimal Information for Quality Control of Botanical Drug Product and its Knowledge Base Implemented using the Entity-Attribute-Value Model. , Fifth Meeting of Consortium for Globalization of Chinese Medicine 5th (CGCM), ZhuHai, GuangDong, PRChina, 20-23 September 2006. |
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Lok C.N., Ho C.M., Chen R., He Q., Yu W.Y., Sun H., Tam P.K.H. and Chiu J., Proteomic analysis of the mode of antibacterial action of silver nanoparticles, Gordon Research Conference, Metal in Medicine, Oxford, United Kingdom, July 9-14, 2006. |
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Lok C.N., Ho C.M., Chen R., He Q., Yu W.Y., Sun H., Tam P.K.H., Chiu J. and Che C.M., Silver nanoparticles: partial oxidation and antibacterial activities, Journal of Biological Inorganic Chemistry. 2007, 12(4): 527-534. |
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Lui V.C.H., Cheng W.C., Leon Y.Y., Lau K.C., Garcia-Barcelo M.M., Miao X., Wall N. and Tam P.K.H., HOXB5 regulates the expression of RET in ENS: a novel Hirschsprung's gene, The 40th Annual Meeting of the Pacific Association of Paediatric Surgeons together with the Annual Scientific Meeting of the Australasian Association of Paediatric Surgeons, Queenstown, New Zealand, 15-19 April 2007. |
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Miao X., Garcia-Barcelo M.M., So M.T., Leon Y.Y., Lau K.C., Liu T., Chan E.K.W., Lan L.C.L., Wong K.K.Y., Lui V.C.H. and Tam P.K.H., Role of RET and PHOX2B gene polymorphisms in risk of Hirschsprung's disease in Chinese population, Gut. 2007, 56(5): 736. |
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Ngan E.S.W., Poon H.C., Sham M.H., Tam P.K.H. and Lui V.C.H., Aberrant KLF4 expression and BMP signaling cause proliferation defect in PTC1-/- neural crest cells (The Best Poster Presentation at the Forum), MGH-HKU-Nature China Forum, Hong Kong, 5-6 March 2007. |
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Ngan E.S.W., Poon H.C., Sham M.H., Hui C.C., Wainwright B., Tam P.K.H. and Lui V.C.H., Aberrant Kruppel-like factor 4 expression causes proliferation defect in Patched1-/- neural crest cells, The 5th Annual Meeting of the International Society for Stem Cell Research, Cairns, Queensland, Australia, 17-20 June 2007. |
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Ngan E.S.W., Sit Y.L.F., Lee K.Y., Miao X., Yuan Z., Wang W.L., Nicholls J.M., Wong K.K.Y., Garcia-Barcelo M.M., Lui V.C.H. and Tam P.K.H., Implications of endocrine gland - derived vascular endothelial growth factor/prokineticin-1 signaling in human neuroblastoma progression., Clinical Cancer Research. 2007, 13(3): 868-875. |
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Ngan E.S.W., Lee K.Y., Sit Y.L.F., Poon H.C., Chan J.K.Y., Sham M.H., Lui V.C.H. and Tam P.K.H., Prokineticin-1 modulates proliferation and differentiation of enteric neural crest cells, Biochimica et Biophysica Acta. 2007, 1773(4): 536-545. |
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Ngan E.S.W., Garcia-Barcelo M.M., Lui V.C.H. and Tam P.K.H., Prokineticins in Neural Crest Cell Growth and Associated Disorders, US Provisional Patent. 2006. |
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Ngan
E.S.W., Lee K.Y., Sit F.Y.L., Chan J.K.Y., Sham M.H., Lui V.C.H. and Tam P.K.H., Roles of Prokineticin |
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Ngan E.S.W., Lui V.C.H., Garcia-Barcelo M.M. and Tam P.K.H., Signaling mechanisms regulating neural crest cells in growth & tumorigenesis [Invited Lecture - Ngan ESW], Stem Cell Workshop: Strategic Research Theme of Development and Reproduction, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, 2-3 November 2006. |
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Ngan E.S.W., Lui V.C.H., Garcia-Barcelo M.M. and Tam P.K.H., Signaling mechanisms regulating neural crest cells: in growth and tumorigenesis (Invited Lecture), Signalling mechanisms regulating neural crest cells: in growth and tumorigenesis, Stem Cell Workshop , SRT of Development and Reproduction, Hong Kong, 2 - 3 November 2006. 2006. |
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Ngan E.S.W., Poon H.C., Sham M.H., Hui C.C., Brandon W., Tam P.K.H. and Lui V.C.H., The Best Poster Presentation, MGH-HKU-Nature China Forum . 2007. |
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Ren Y., Xie Y., Chan H.M. and Tam P.K.H., Visinin like protein 1 (VILIP-1) enhances neuroblastoma cell migration, 53rd Annual International Congress of the British Association of Paediatric Suregons, Stockholm, Sweden, 18-21 July 2006. |
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Rong J., Shen J., Ng K.M., Liu C., Tam P.K.H. and Lau A.S.Y., Application Of Biological Response Fingerprinting (BioReF) To Define Marker Genes As Potential Quality Control Of Botanical Drug Products, 2006 World Congress on Chinese Medicine (CM2006). 2006. |
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Rong J., Shen J., Ng K.M., Liu C., Tam P.K.H. and Lau A.S.Y., Genome-wide biological response fingerprinting (BioReF) enables selection of multiple marker genes as potential quality control of botanical drug products, Fifth Meeting of Consortium for Globalization of Chinese Medicine (CGCM). 2006. |
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Rong J., Cheung Y.H., Shen J., Tam P.K.H. and Lau A.S.Y., Genome-wide biological response fingerprinting (BioReF) of Traditional Chinese Medicine formula ISF-1 reveals a potential role of heme oxygenase-1 pathway in the antioxidant therapy, The 7th International Conference of System Biology. 2006. |
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Rong J., Tilton R., Shen J., Ng K.M., Liu C., Tam P.K.H., Lau A.S.Y. and Cheng Y.C., Genome-wide biological response fingerprinting (BioReF) of the Chinese botanical formulation ISF-1 enables the selection of multiple marker genes as a potential metric for quality control, Journal of Ethnopharmacology. 2007, 113: 35-44. |
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Tam P.K.H., Advances in Hirschsprung's diseases [Invited Lecture], Special Lecture for the Istituto Giannina Gaslini, Genoa, Italy, 21 March 2007. 2007. |
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Tam P.K.H., Advances in Paediatric Surgery [Invited Lecture], 12th Annual Meeting of Paediatric Surgery in Shandong, Jinan, China, 28 August 2006. 2006. |
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Tam P.K.H., Advances in neuroblastoma research: role of MIF in neuroblastoma [Inived lecture], The 2nd Cross Strait Symposium on Pediatric Oncology, Kaohsiung, Taiwan, 21-23 September 2006. 2006. |
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Tam P.K.H., Approaches to the genetic analysis of an oligogenic disease: Hirschsprung's disease [Invited Lecture], The 8th International Meeting on Human Genome Variation and Complex Genome Analysis, Hong Kong, 14-16 September 2006. 2006. |
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Tam P.K.H., Genetics and developmental biology of Hirschsprung's disease [Invited Lecture], The First National Congress of Pediatric Surgery in Experiment and Clinic, Shenyang, China, 26-28 August 2006. 2006. |
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Tam P.K.H., Genetics of Hirschsprung's disease [Invited lecture], 20th Congress of Asian Association of Pediatric Surgeons (AAPS) with WOFAPS Executive Meeting, New Delhi, India, 12-15 November 2006. 2006. |
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Tam P.K.H., Hirschsprung's disease: new insights in pathophysiology [Invited lecture], Latest Advances in Fetal & Neonatal Surgery, Hong Kong, 22-24 November 2006. 2006. |
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Tam P.K.H., Hirschsprung's disease: new insights in pathophysiology and therapy [Invited Lecture], The 44th Annual Meeting of Japanese Society of Pediatric Surgeons, Tokyo, Japan, 31 May - 2 June 2007. 2007. |
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Tam P.K.H., Laparoscopic rectoanoplasty: a new gold standard for imperforate anus [Invited Lecture], 1st S.K. Yee Medical Foundation: Laparoscopic Workshop in China, Beijing, China, 21-24 June 2007. 2007. |
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Tam P.K.H., Molecular dissection of genetic basis of a multifactorial disorder: Hirschsprung's disease [Invited Lecture], International Congress of Global Chinese Geneticists, Beijing, China, 2-4 August 2006. 2006. |
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Tam P.K.H., Posterior Sagittal Anorectoplasty (PSARP): a versatile technique for anorectal malformations [Invited lecture], Latest Advances in Fetal & Neonatal Surgery, Hong Kong, 22-24 November 2006. 2006. |
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Tam P.K.H., President-Elect of Pacific Association of Pediatric Surgeons, 2006-2007. 2006. |
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Tam P.K.H., Recent advances in paediatric surgery [Invited Lecture], Department of Paediatrics, Kwong Wah Hospital, Hong Kong on 17 August 2006. 2006. |
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Tam P.K.H., Surgical treatment of intersex disorders [Invited Lecture], 4th International Huaxia Congress of Endocrinology, Hong Kong, 15-18 December 2006. 2006. |
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Tam P.K.H., The 7th Lawrence G. Crowley Distinguished Lectureship, Departments of Surgery and Pediatrics, Lucile Salter Packard Children's Hospital, Stanford University Medical Centre, U.S.A. 11 May 2007. 2007. |
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Tam P.K.H., Garcia-Barcelo M.M., Tullio-Pelet A., Lyonnet S., Lantieri F., Kashuk C., Hofstra R., Griseri P., Fernandez R., Eng C., Emison E., Burzynski G., Ceccherini I., Borrego S., Antinolo G., Amiel J., West K. and Chakravarti A., The International Hirschsprung's Disease Consortium: differential liabiilties of coding and non-coding mutations in complex disease, 53rd Annual International Congress of the British Association of Paediatric Suregons, Stockholm, Sweden, 18-21 July 2006. |
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Tam P.K.H., The New Silk Road: from surgery to science [Invited Lecture], The 7th Lawrence G. Crowley Distinguished Lectureship, Departments of Surgery and Pediatrics, Lucile Salter Packard Children's Hospital, Stanford University Medical Centre, U.S.A., 11 May 2007. 2007. |
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Tam P.K.H., Wong K.K.Y. and Lan L.C.L., The impact of laparoscopic appendicectomy on pediatric surgical training, 20th Congress of Asian Association of Pediatric Surgeons (AAPS) with WOFAPS Executive Meeting, New Delhi, India, 12-15 November 2006. |
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Tam P.K.H., Transanal endorectal pullthrough for Hirschsprung's disease [Invited lecture], Latest Advances in Fetal & Neonatal Surgery, Hong Kong, 22-24 November 2006. 2006. |
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Tam P.K.H., Visiting Professor (July 2006 - present), China Medical University, Shenyang, China. 2006. |
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Tian J., Wong K.K.Y., Ho C.M., Lok C.N., Yu W.Y., Che C.M., Chiu J. and Tam P.K.H., Topical delivery of silver nanoparticles promotes wound healing, ChemMedChem. 2007, 2: 129-136. |
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Wong K.K.Y., Foo D., Lan L.C.L. and Tam P.K.H., Is prenatal diagnosis of choledochal cysts beneficial?, The 40th Annual Meeting of the Pacific Association of Paediatric Surgeons together with the Annual Scientific Meeting of the Australasian Association of Paediatric Surgeons, Queenstown, New Zealand, 15-19 April 2007. |
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Wong K.K.Y., Fang C.X. and Tam P.K.H., Selective upper endoscopy for foreign body ingestion in children: an evaluation of management protocol after 282 cases, Journal of Pediatric Surgery. 2006, 41 (12): 2016-2018. |
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Wong K.K.Y., Leung K.H., Lan L.C.L., Tam P.K.H. and Chan H.Y., The impact of antenatal diagnosis on small bowel atresia revisited, The 40th Annual Meeting of the Pacific Association of Paediatric Surgeons together with the Annual Scientific Meeting of the Australasian Association of Paediatric Surgeons, Queenstown, New Zealand, 15-19 April 2007. |
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Wong K.K.Y., Tian J., Ho C.M., Lok C.N., Che C.M., Chiu J. and Tam P.K.H., Topical delivery of silver nanoparticles reduces systemic inflammation of burn and promotes wound healing, Nanomedicine : nanotechnology, biology, and medicine. 2006, 2(4): 306. |
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Researcher
: Tang CM |
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List of Research Outputs |
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Tang
C.M., Role of cyclooxygenase |
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Researcher
: Tian J |
|
List of Research Outputs |
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Tian J., Wong K.K.Y., Ho C.M., Lok C.N., Yu W.Y., Che C.M., Chiu J. and Tam P.K.H., Topical delivery of silver nanoparticles promotes wound healing, ChemMedChem. 2007, 2: 129-136. |
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Wong K.K.Y., Tian J., Ho C.M., Lok C.N., Che C.M., Chiu J. and Tam P.K.H., Topical delivery of silver nanoparticles reduces systemic inflammation of burn and promotes wound healing, Nanomedicine : nanotechnology, biology, and medicine. 2006, 2(4): 306. |
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Researcher
: Tian J |
|
List of Research Outputs |
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Tian J., Wong K.K.Y., Ho C.M., Lok C.N., Yu W.Y., Che C.M., Chiu J. and Tam P.K.H., Topical delivery of silver nanoparticles promotes wound healing, ChemMedChem. 2007, 2: 129-136. |
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Wong K.K.Y., Tian J., Ho C.M., Lok C.N., Che C.M., Chiu J. and Tam P.K.H., Topical delivery of silver nanoparticles reduces systemic inflammation of burn and promotes wound healing, Nanomedicine : nanotechnology, biology, and medicine. 2006, 2(4): 306. |
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Researcher
: Tian L |
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List of Research Outputs |
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Chan V.S.F., Chau S.Y., Tian L., Chen Y., Kwong S.K.Y., Quackenbush J., Dallman M., Lamb J. and Tam P.K.H., Sonic hedgehog promotes CD4+ T lymphocyte proliferation and modulates the expression of a subset of CD28-targeted genes, International Immunology. 2006, 18(12): 1627-1636. |
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Chen Y., Li X., Tian L., Lui V.C.H., Dallman M.J., Lamb J.R. and Tam P.K.H., Inhibition of sonic hedgehog signaling reduces chronic rejection and prolongs allograft survival in a rat orthotopic small bowel transplantation model, Transplantation. 2007, 83(10): 1351-1357. |
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Chen Y., Liu Y., Yuan Z., Tian L., Dallman M.J., Thompson P.W., Tam P.K.H. and Lamb J.R., Rosiglitazone suppresses cyclosporin-induced chronic transplant dysfunction and prolongs survival of rat cardiac allografts, Transplantation. 2007, 83(12): 1602-1610. |
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Researcher
: Ting ACW |
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List of Research Outputs |
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Chan Y.C., Ting A.C.W., Ho P., Poon J.T.C., Yiu W.K. and Cheng S.W.K., Supra-aortic hybrid endovascular procedures for complex thoracic aortic disease (Best Paper Session), Conjoint Scientific Congress of the Royal College of Surgeons of England and the College of Surgeons of Hong Kong, Hong Kong, 6-7 May 2007. |
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Chan Y.C., Ting A.C.W., Poon J.T.C., Yiu W.K., Cheung G.C.Y. and Cheng S.W.K., Ten year epidemiological review of in-hospital patients with Marfan syndrome, Conjoint Scientific Congress of the Royal College of Surgeons of England and the College of Surgeons of Hong Kong, Hong Kong, 6-7 May 2007. |
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Ho P., Cheng S.W.K., Ting A.C.W., Poon J.T.C. and Liu L.H.L., Hybrid endovascular operation for ruptured thoracic aortic aneurysm (Case report), Hong Kong Medical Journal. 2007, 13(1): 78-80. |
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Ng T.P., Lai A., Wong L., Ting A.C.W. and Chiu P.K.Y., Unusual cause of deep vein thrombosis - Iliopsoas bursa compressing the femoral vein, The 26th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2006, 10: S93. |
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Ting A.C.W., Case presentation, Session on "Taming the Challenges in Vascular Surgery", Hong Kong Surgical Fourm, Hong Kong, 7-8 July 2006. 2006. |
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Ting A.C.W., Cheng S.W.K., Ho P. and Poon J.T.C., Endovascular stent graft repair for infected thoracic aortic pseudoaneurysms - a durable option?, Journal of Vascular Surgery. 2006, 44(4): 701-705. |
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Ting A.C.W. and Cheng S.W.K., Images in vascular medicine. Pseudoaneurysm as a result of peripheral arterial stent infection, Vascular Medicine. 2006, 11(3): 171-172. |
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Ting A.C.W., Management of abdominal aortic aneurysm, Conjoint Scientific Congress of the Royal College of Surgeons of England and the College of Surgeons of Hong Kong, Hong Kong, 6-7 May 2007. |
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Researcher
: To JYT |
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List of Research Outputs |
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Ho
D.W.Y., Yang Z., Lau C.K., Tam K.H., To J.Y.T., Poon R.T.P. and Fan S.T., Therapeutic potential of
cardiotrophin |
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Researcher
: Tse TF |
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List of Research Outputs |
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Tse T.F. and Chu K.M., Role of RON activation in chemoresistance in gastric cancer, Presented at 11th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong. 7 December 2006. |
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Tse T.F. and Chu K.M., Role of RON activation in chemoresistance in gastric cancer, Presented at 20th World Congress of Digestive Surgery, Rome, Italy, 29 November - 1 December 2006. |
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Tse T.F. and Chu K.M., Role of RON activation in chemoresistance in gastric cancer, Thesis. 2007. |
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Tse T.F., Role of RON activation on chemoresistance in gastric cancer, Thesis, Master of Philosophy, The University of Hong Kong. 2007. |
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Researcher
: Tsui TY |
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Project Title: |
Identification possible role of heme oxygenase-1 on the regulation of T cell activation |
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Investigator(s): |
Tsui TY |
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Department: |
Surgery |
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Source(s) of Funding: |
Seed Funding Programme for Basic Research |
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Start Date: |
02/2004 |
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Abstract: |
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To identify the possible role of HO |
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List of Research Outputs |
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Tsui T.Y., Obed A., Siu Y.T., Yet S.F., Prantl L., Schlitt H.J. and Fan S.T., Carbon monoxide inhalation rescues mice from fulminant hepatitis through improving hepatic energy metabolism, Shock. 2007, 27(2): 165-171. |
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Researcher
: Wang X |
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Project Title: |
Cdc |
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Investigator(s): |
Wang X, Fan S T, Stanbridge EJ |
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Department: |
Surgery |
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Source(s) of Funding: |
Seed Funding Programme for Basic Research |
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Start Date: |
11/2005 |
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Abstract: |
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Objectives: 1. To determine and confirm
whether there is a defective Cdc |
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Project Title: |
Aberrant Notch pathway activation is associated with metastatic epithelial-to-mesenchymal transition in hepatocellular carcinoma. |
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Investigator(s): |
Wang X, Poon RTP |
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Department: |
Surgery |
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Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
02/2007 |
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Abstract: |
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Background and rational: Notch is a cell signaling system that regulates cell fate specification, stem cell maintenance and initiation of differentiation in embryonic and postnatal tissues. Notch ligands (Delta-like-1, 3, 4 and Jagged1-2) and Notch receptors (Notch1-4) are type I membrane proteins. Notch signaling initiates through ligand-receptor interactions between two neighboring cells, leading to proteolytic cleavages and release the Notch intracellular domain into the nucleus, which further activates transcription of target genes. Notch activation is oncogenic in many instances. Its intracellular domain acts as oncogenes in vitro and in animal models. Deregulated expression of Notch receptors, ligands, and targets is observed in some solid tumors. The molecular basis for the oncogenic activity of Notch is still unclear. Notch has been shown to promote epithelial-to-mesenchymal transition (EMT) during normal organ's development; therefore, it is possible that Notch may also be involved in the EMT process that occurs during tumor progression to convert epithelial cell into invasive cells. To date, Notch pathway has not been associated with HCC. If so, which downstream pathway involved and how it affects HCC carcinogenesis are still unknown. Based on our preliminary data, Notch1 and Jagger1 are highly expressed in metastatic HCC cells compared to non-metastatic HCC cells; we hypothesize that Notch pathway might be associated with invasive HCC through induction of metastatic EMT.Objectives:1. To compare and confirm our preliminary observations that Notch1, Jagger1, and some Notch target genes are over-expressed in metastatic HCC cell lines but not in non-metastatic HCC cells.2. To investigate Notch ligand and receptor gene expression in clinical hepatocellular carcinoma (HCC) and its association with HCC metastasis. This will be the first study on abnormal activation of Notch pathway in HCC.3. To understand whether Notch signaling pathway is associated with tumor metastatic EMT in HCC. This part of study will understand a) whether metastatic EMT in HCC is mediated by Notch pathways. b) If so, which downstream elements of Notch signaling may be involved? We will focus on Notch-Snail pathway as both genes have been shown to function on developmental EMT. 4. To determine the biological effects of Notch pathway on HCC tumorigenesis and metastasis. This part of study will be performed on Notch1 RNA interfere cells to observe cell growth, cell motility in vitro; to observe HCC tumorgenesis and metastasis in vivo in mice model.5. Using Notch1 inhibitor (DAPT or γ-Secretase inhibitors GSI) to inhibit Notch1 activation in metastatic HCC cells to see whether it could reverse metastatic EMT phenotype and induce E-cadherin expression. It might provide evidence that Notch inhibition could be a potential new therapeutic direction for metastatic HCC. |
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List of Research Outputs |
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Wang X., Redpath J.L., Fan S.T. and Stanbridge E.J., ATR dependent activation of Chk2 and Chk1, Journal of Cellular Physiology. 2006, 208: 613-619. |
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Wang X. and Fan S.T., Chemotherapy increases expression of stem cell marker and cell migration in hepatocellular carcinoma cells (Abstract), 4th International Society for Stem Cell Research Annual Meeting, Toronto, Canada, 1 July 2006. |
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Wang X., Luk J.M.C., Garcia-Barcelo M.M., Miao X., Leung P.L., Ho D.W.Y., Cheung S.T., Lam B.Y.H., Cheung C.K.Y., Wong S.Y., Lau S.S.M., So M.T., Yu W.C., Cai Q., Liu K.S.Y., Hui C.K., Lau G., Poon R.T.P., Wong J. and Fan S.T., Liver intestine-cadherin (CDH17) haplotype is associated with increased risk of hepatocellular carcinoma, Clinical Cancer Research. 2006, 12(17): 5248-5252. |
|
Wang X., Miao X., Cai Q., Garcia-Barcelo M.M. and Fan S.T., SMYD3 tandem repeats polymorphism is not associated with the occurrence and metastasis of hepatocellular carcinoma in a Chinese population, Experimental Oncology. 2007, 29(1): 71-73. |
|
Researcher
: Wang Y |
|
List of Research Outputs |
|
Man K., Xiao J., Ng T.P., Cheng Q., Sun B., Wang Y., Sun K.W., Poon R.T.P. and Lo C.M., Adiponectin as a novel therapy for the suppression of the liver cancer growth and metastasis (Paper Presentation), the 14th European Organisation for the Research and Treatment of Cancer, National Cancer Institute, and American Association for Cancer Research (EORTC-NCI-AARC) Symposium on Molecular Targets and Cancer Therapeutics, Prague, Czech Republic, 7 - 10 November 2006. European Journal of Cancer Supplement. 2006, 50. |
|
Man K., Lo C.M., Xiao J., Ng T.P., Sun K.W., Wang Y. and Fan S.T., The significance of acute phase graft injury on tumor recurrence/metastases in live donor liver transplantation (Abstract), World Transplant Congress 2006, Boston, U.S.A., 22 -27 July 2006. |
|
Man K., Lo C.M., Xiao J., Ng T.P., Sun K.W., Wang Y. and Fan S.T., The significance of graft size on tumor recurrence after liver transplantation - activation of cell invasion pathway (Abstract), World Transplant Congress 2006, Boston, U.S.A., 22 - 27 July 2006. |
|
Researcher
: Wei WI |
|
Project Title: |
Intra-arterial chemoradiation for advanced head and neck cancer |
|
Investigator(s): |
Wei WI, Sham JST |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
07/2002 |
|
Abstract: |
|
To see if chemotherapy and radiotherapy given can help patients with advanced head and neck cancer. |
|
Project Title: |
Modifications of techniques of cochlear implantation |
|
Investigator(s): |
Wei WI, Au DKK, Ho WK |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
09/2002 |
|
Abstract: |
|
To study the technique and mode of insertion of cochlear implant aiming to improve the efficacy of the implant. |
|
Project Title: |
Quantitative analysis of plasma Epstein-Barr-Virus DNA in nasopharyngeal carcinoma after salvage nasopharyngectomy |
|
Investigator(s): |
Wei WI |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
09/2002 |
|
Abstract: |
|
To study early detection of recurrence after radiotherapy for nasopharyngeal cancer. |
|
Project Title: |
Management of snoring and OSA |
|
Investigator(s): |
Wei WI, Ho WK |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
09/2002 |
|
Abstract: |
|
To find the incidence of snoring and OSA and advance their treatments. |
|
Project Title: |
VEGF in nasopharyngeal cancer |
|
Investigator(s): |
Wei WI, Kwong DLW, Poon RTP |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
03/2003 |
|
Abstract: |
|
To carry out early detection of nasopharyngeal cancer before radiotherapy and after treatment. |
|
Project Title: |
Study the spread of aerosol during tracheostomy or intubation |
|
Investigator(s): |
Wei WI, Sham JST, Irwin MG |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
04/2003 |
|
Abstract: |
|
To investigate the distance and pattern of aerosol spread during surgical procedures in application to SARS. |
|
Project Title: |
Speech rehabilitation after total laryngectomy - self help and mutual help |
|
Investigator(s): |
Wei WI, Ho WK |
|
Department: |
Surgery |
|
Source(s) of Funding: |
S.K. Yee Medical Foundation - General Award |
|
Start Date: |
10/2003 |
|
Abstract: |
|
To visit the hospitals and centres in China where total laryngectomy is performed for patients suffering from cancer of the larynx. |
|
Project Title: |
Head and neck course in China - to teach techniques of contemporary operations and patient care for doctors and nurses working in underdeveloped areas in China. This will benefit those poor patients suffereing from head and neck cancer in China |
|
Investigator(s): |
Wei WI, Lam LK, Hui Y, Ng WM |
|
Department: |
Surgery |
|
Source(s) of Funding: |
S.K. Yee Medical Foundation - General Award |
|
Start Date: |
10/2003 |
|
Abstract: |
|
To teach head and neck surgeons in China the contemporary methods of managing patients suffering from head and neck cancer and also to introduce the concept of optimal nursing care for these patients. |
|
Project Title: |
Cochlear implant for 14 profoundly deaf children in China |
|
Investigator(s): |
Wei WI, Au DKK, Hui Y |
|
Department: |
Surgery |
|
Source(s) of Funding: |
S.K. Yee Medical Foundation - General Award |
|
Start Date: |
10/2003 |
|
Abstract: |
|
To help Chinese children who are profoundly deaf in China to receive the cochlear implant, so that they will be able to hear, speak and to receive education effectively. |
|
Project Title: |
Speech rehabilitation after total laryngectomy - self help and mutual help |
|
Investigator(s): |
Wei WI, Lam PKY, Ho LM, Kwok ICL |
|
Department: |
Surgery - Otorhinolaryngology Un |
|
Source(s) of Funding: |
S.K. Yee Medical Foundation - General Award |
|
Start Date: |
07/2005 |
|
Abstract: |
|
To provide coaching to another laryngectomee who has learned to speak again after surgery to teach patients to speak again. |
|
Project Title: |
Cochlear implant for 14 profoundly deaf Chinese children in China |
|
Investigator(s): |
Wei WI, Hui Y, Au DKK |
|
Department: |
Surgery - Otorhinolaryngology Un |
|
Source(s) of Funding: |
S.K. Yee Medical Foundation - General Award |
|
Start Date: |
07/2005 |
|
Abstract: |
|
To provide profoundly deaf in China a chance to received cochlear implant so that they can learn to hear and speak, and receive normal mainstream education. |
|
Project Title: |
Head and neck course in China - to teach techniques of contemporary operations and patient care for doctors and nurses working in relatively underdeveloped areas in China |
|
Investigator(s): |
Wei WI, Lam LK, Hui Y, Lam PKY, Li GKH |
|
Department: |
Surgery - Otorhinolaryngology Un |
|
Source(s) of Funding: |
S.K. Yee Medical Foundation - General Award |
|
Start Date: |
07/2005 |
|
Abstract: |
|
To teach head and neck surgeons in China the contemporary methods of managing patients suffering from head and neck cancer and also to introduce the concept of optimal nursing care for these patients. |
|
List of Research Outputs |
|
Cense H.A., Law S.Y.K., Wei W.I., Lam L.K., Ng W.M., Wong K.H., Kwok K.F. and Wong J., Pharyngolaryngoesophagectomy using the thoracoscopic approach, Surgical Endoscopy. 2007, 21(6): 879-884. |
|
Cense H.A., Law S., Wei W.I., Lam L.K., Ng W.M., Wong K.H., Kwok K.F. and Wong J., Surg Endosc, Pharyngolaryngoesophagectomy using the thoracoscopic approach. 2007, 21: 879-884. |
|
Chan H.H.L., Yang C., Leung J.C.K., Wei W.I. and Lai K.N., An Animal Study of the Effects on p16 and PCNA Expression of Repeated Treatment with High-Energy Laser and Intense Pulsed Light Exposure, Lasers in Surgery and Medicine. 2007, 39: 8-13. |
|
Chan H.H.L., Manstein D., Yu C.S., Shek S., Kono T. and Wei W.I., The prevalence and risk factors of post-inflammatory hyperpigmentation after fractional resurfacing in Asians, Lasers in Surgery and Medicine. 2007, 39: 381-385. |
|
Chan W.S., Wei W.I. and Tse H.F., "Malignant" baroreflex failure after surgical resection of carotid body tumor, International Journal of Cardiology. 2007, 118: e81-82. |
|
Ferlito A., Rinaldo A., Silver C.E., Shah J.P., Suarez C., Medina J.E., Kowalski L.P., Johnson J.T., Strome M., Rodrigo J.P., Werner J.A., Takes R.P., Towpik E., Robbins K.T., Leemans C.R., Herranz J., Gavilan J., Shaha A.R. and Wei W.I., Neck dissection: Then and now, Auris Nasus Larynx. 2006, 33: 365-374. |
|
Ho D.W.Y., Yang Z., Wong B.Y.H., Kwong D.L.W., Sham J.S.T., Wei W.I. and Yuen P.W., Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry serum protein profiling to identify nasopharyngeal carcinoma, Cancer. 2006, 107(1): 99-107. |
|
Ho W.K., Yang Z., Wong B.Y., Kwong D.L.W., Sham J.S.T., Wei W.I. and Yuen P.W., Cancer, Surface-enhanced laser desorption / ionization time-of-flight mass spectrometry serum protein profiling to identify nasopharyngeal carcinoma. 2006, 107: 99-107. |
|
Howard D.J., Lund V.J. and Wei W.I., Craniofacial resectin for tumours of the nasal cavity and paranasal sinuses: A 25-year experience, Head Neck. 2006, 28: 867-73. |
|
Ji M.F., Wang D.K., Yu Y.L., Guo Y.Q., Liang J.S., Cheng W.M., Zong Y.S., Chan K.H., Ng S.P., Wei W.I., Chua D.T.T., Sham J.S.T. and Ng M.H., Sustained elevation of Epstein-Barr virus antibody levels preceding clinical onset of nasopharyngeal carcinoma., British Journal of Cancer. 2007, 96: 623-630. |
|
Lam P.K.Y., Chan K.M.K., Ho W.K., Kwong E.Y.L., Yiu E.M.L. and Wei W.I., Cross-cultural Adaptation and Validation of the Chinese Voice Handicap Index-10, Laryngoscope. Hagerstown, MD, Lippincott Williams & Wilkins, Inc., 2006, 116(7): 1192-1198. |
|
Lam P.K.Y., Ho W.K., Ng M.L. and Wei W.I., Medialization thyroplasty for cancer-related unilateral vocal fold paralysis, In: Richard M. Rosenfeld MD, MPH, Otolaryngology - Head and Neck Surgery. 2007, 136: 440-444. |
|
Lee D.C.W., Chua D.T.T., Sham J.S.T., Wei W.I. and Lau A.S.Y., Differential induction of matrix metallo-proteinase 3 by Epstein-Barr virus latent membrane protein 1, Organisation for Oncology and Translational Research 3rd Annual Conference, Hong Kong Academy of Medicine (Neoadjuvant & Molecular Therapy in Cancer), 22-23 September 2006. |
|
Lund V., Howard D.J. and Wei W.I., Endoscopic resection of malignant tumors of the nose and sinuses, American Journal of Rhinology. 2007, 21: 89-94. |
|
Wei W.I., Archives of Otolaryngology - Head & Neck Surgery, USA, Honorary Reviewer. 2006. |
|
Wei W.I., Asian Journal of Surgery, Hong Kong, Honorary Reviewer. 2006. |
|
Wei W.I., Asian Surgical Journal, Associate Editor, 1985 - present. 2006. |
|
Wei W.I., Auris Nasus Larynx, Editorial Board Member, 2005 - present. 2006. |
|
Wei W.I., Australian and New Zealand Journal of Surgery, Editorial Board Member, 1995 - present. 2006. |
|
Wei W.I., Bone Marrow Transplanation, UK, Honorary Reviewer. 2006. |
|
Wei W.I., British Journal of Surgery, UK, Honorary Reviewer. 2006. |
|
Wei W.I., Cancer (Interdiscipline International Journal of the American Cancer Society), USA, Honorary Reviewer. 2006. |
|
Wei W.I., Chinese Archives of Otolaryngology & Head and Neck Surgery, Editorial Board Member, 2006 - present. 2006. |
|
Wei W.I., Chinese Journal of Cancer, Editorial Board Honorary Member, 1999 - present. 2006. |
|
Wei W.I., Chinese Journal of Clinical Oncology, Editorial Board Member, 1995 - present. 2006. |
|
Wei W.I., Chinese Journal of Otolaryngology, Editorial Board Member, 1996 - present. 2006. |
|
Wei W.I. and Wei W.I., Clinical Cancer Research, USA, Honorary Reviewer. 2006. |
|
Wei W.I. and Ng W.M., Complications of resection of malignant tumours of the skull base: outcome and solution, European Archive of Otorhinolaryngology. 2007, 264: 733-9. |
|
Wei W.I., Head & Neck (Journal for the Sciences and Specialties of the Head and Neck), USA, Honorary Reviewer. 2006. |
|
Wei W.I., Head & Neck, Associte Editor, 2007 - 2010. 2007. |
|
Wei W.I., Hong Kong Academy of Medicine, Hong Kong, Elected Council Member, 2005 -2007. 2006. |
|
Wei W.I., International Federation of Head and Neck Oncologic Societies, Secretary General, 2006 - present. 2006. |
|
Wei W.I., International Journal of Cancer (Officical Journal of UICC), Germany, Honorary Reviewer. 2006. |
|
Wei W.I., Journal of Clinical Otorhinolaryngology (China), Editoral Board Member, 1997 - present. 2006. |
|
Wei W.I., Medical Progress, Editorial Board Member, 2003 - present. 2006. |
|
Wei W.I., Oncology (Internatinal Journal of Cancer Research and Treatment), Switzerland, Honorary Reviewer. 2006. |
|
Wei W.I., Otolaryngology Head and Neck Surgery - American Academy of Otolaryngology, Head & Neck Surgery, International Advisor Board Member, 2001 - present. 2006. |
|
Wei W.I., Skull Base, Editorial Board Member, 2005 - present. 2006. |
|
Wei W.I., The American Journal of Otolaryngology, Editorial Board Member, 1994 - present. 2006. |
|
Wei W.I., The American Journal of Rhinology, USA, Honorary Reviewer. 2006. |
|
Wei W.I., The American Journal of Surgery, USA, Honorary Reviewer. 2006. |
|
Wei W.I., The Asean ORL Head and Neck Journal, Editorial Board Member, 1997 - present. 2006. |
|
Wei W.I., The Clinical and Experimental Otorhinolaryngolgy, International Editorial Board Member, 2007 - present. 2007. |
|
Wei W.I., The First Medical School, West China University of Medical Sciences, Chengdu, Sichuan, China, Honorary Director, 1997 - present. 2006. |
|
Wei W.I., The Hong Kong Practitioner (Journal of the Hong Kong College of Family Physicians), Hong Kong, Honorary Reviewer. 2006. |
|
Wei W.I., The Laryngoscope, USA, Honorary Reviewer. 2006. |
|
Wei W.I. and Ng W.M., The management of neck metastases in nasopharyngeal cancer, Current Opinion Otolaryngology Head and Neck Surgery. 2007, 15: 99-102. |
|
Wei W.I., 中國醫學文摘耳鼻咽喉科學, 第三屆學術委員會委員, 2006 - 2008, 2006. |
|
Wei W.I., 中華普通外科雜誌, 第三屆中華普通外科雜誌編輯會編輯委員, 2006 - present, 2006. |
|
Wei W.I., 中國耳鼻咽喉顱底外科雜誌, 第三屆編委, 2006 - 2009, 2006. |
|
Wei W.I., 中華耳鼻咽喉頭頸外科雜誌, 第八屆編委, 2005 - present, 2006. |
|
Xiao H., Au D.K.K., Hui Y., Chow C.K., Fan Y.W. and Wei W.I., Neurofibromatosis type 2 and auditory brainstem implantation., Chinese Medical Journal. 2007, 120(16): 1456-1459. |
|
Researcher
: Wo YH |
|
List of Research Outputs |
|
Liu Y., Lei L., Lui E.L.H., Lau C.P.Y., Chen Y., Wo Y.H., Fan S.T. and Poon R.T.P., Tyrosine kinase inhibitor PTK 787/ZK222584 inhibits liver fibrosis (Abstract), The 17th Asian Pacific Association for the Study of the Liver Conference, Kyoto, Japan, 27 - 30 March 2007. Hepatology International. 2007, 1(1): 206. |
|
Luk J.M.C., Zhang Q.S., Lee P.Y., Wo Y.H., Leung P.L., Liu L.X., Hu M.Y., Cheung K.F., Hui C.K., Lau G. and Fan S.T., Hepatic stellate cell-targeted delivery of M6P-HSA-glycyrrhetinic acid attenuates hepatic fibrogenesis in a bile duct ligation rat model, Liver International. 2007, 27(4): 548-557. |
|
Ma S.K.Y., Chan K.W., Hu L., Lee K.W., Ng I.O.L., Wo Y.H., Zheng B. and Guan X.Y., Identification and characterization of tumorigenic liver cancer stem cells, Proceedings of the Annual Meeting of American Association for Cancer Research, Los Angeles, USA, April. 2007. |
|
Ma S.K.Y., Chan K.W., Hu L., Lee K.W., Wo Y.H., Ng I.O.L., Zheng B. and Guan X.Y., Identification and characterization of tumorigenic liver cancer stem/progenitor cells, Gastroenterology. 2007, 132(7): 2542-2556. |
|
Researcher
: Wong J |
|
Project Title: |
Randomised prospective trial comparing the use of neck drain after oesophagectomy with cervical anastomosis |
|
Investigator(s): |
Wong J, Law SYK |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
01/1994 |
|
Abstract: |
|
To evaluate the need of routine cervical drains after oesophagectomy. |
|
Project Title: |
Thoracoscopic cardiomyotomy for achalasia |
|
Investigator(s): |
Wong J, Law SYK |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
01/1994 |
|
Abstract: |
|
To study the efficacy of a new approach of surgical treatment for achalasia, using endoscopic instruments via tiny incisions into the thoracic cavity, thus avoiding the complications and discomforts if long surgical incision from traditional surgical approach. |
|
Project Title: |
Randomised prospective trial investigating the effect of preoperative chemo-radiation for resectable carcinoma of the oesophagus |
|
Investigator(s): |
Wong J, Law SYK |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
01/1995 |
|
Abstract: |
|
To evaluate the use of preoperative chemo-radiation for treatment of oesophageal cancer. |
|
Project Title: |
Prospective study of the use of chemoradiotherapy in the treatment of advanced carcinoma of the oesophagus not suitable for resection |
|
Investigator(s): |
Wong J, Law SYK |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
01/1995 |
|
Abstract: |
|
To evaluate the use of chemoradiotherapy in the treatment of advanced carcinoma of the oesophagus not suitable for resection. |
|
Project Title: |
Retrospective and prospective study on the use of chemotherapy and chemoradiotherapy in the treatment of recurrent disease after oesophagectomy for cancer |
|
Investigator(s): |
Wong J, Law SYK |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
01/1995 |
|
Abstract: |
|
To evaluate the use of chemotherapy and spare chemoradiotherapy in the treatment of recurrent disease. |
|
Project Title: |
Thoracoscopic oesophagectomy for carcinoma of the oesophagus |
|
Investigator(s): |
Wong J, Law SYK |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
04/1996 |
|
Abstract: |
|
To study the efficacy of an endoscopic approach in the resection of oesophageal carcinoma without the necessity of a conventional open thoracotomy. This would have the benefit of decreasing the incidence of pulmonary complications and deaths related to these complications associated with conventional surgery. Thoracoscopic oesophagectomy will also be compared with the transhiatal approach to see whether there are differences in morbidit, mortality and survival. |
|
Project Title: |
The use of endoscopic ultrasound in staging of esophageal cancer |
|
Investigator(s): |
Wong J, |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
07/1996 |
|
Abstract: |
|
To evaluate the accuracy and use of endoscopic ultrasound in the management of esophageal cancer. |
|
Project Title: |
Clinical significance of hepatocyte growth factor in esophageal squamous cell carcinoma |
|
Investigator(s): |
Wong J, Law SYK, Ren Y |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2003 |
|
Abstract: |
|
To investigate whether relationships
exist between serum HGF levels and angiogenic factors, clinico- pathological
factors, and long-term survival; to study whether HGF correlates with
angiogenic factors such as VEGF and IL |
|
List of Research Outputs |
|
Cense H.A., Law S.Y.K., Wei W.I., Lam L.K., Ng W.M., Wong K.H., Kwok K.F. and Wong J., Pharyngolaryngoesophagectomy using the thoracoscopic approach, Surgical Endoscopy. 2007, 21(6): 879-884. |
|
Cense H.A., Law S., Wei W.I., Lam L.K., Ng W.M., Wong K.H., Kwok K.F. and Wong J., Surg Endosc, Pharyngolaryngoesophagectomy using the thoracoscopic approach. 2007, 21: 879-884. |
|
Chan S.C., Fan S.T., Lo C.M., Liu C.L. and Wong J., Toward current standards of donor right hepatectomy for adult-to-adult live donor liver transplantation through the experience of 200 cases, Annals of Surgery. 2007, 245(1): 110-117. |
|
Cheung C.M., Tang J.C.O., Lee P.Y., Hu L., Guan X.Y., Srivastava G., Wong J., Luk J.M.C. and Law S.Y.K., Establishment and characterization of a new xenograft-derived human esophageal squamous cell carcinoma cell line HKESC-4 of chinese origin, 11th Research Postgraduate Symposium (11th RPS), The University of Hong Kong Li Ka Shing Faculty of Medicine, Hong Kong, 7 December. 2006. |
|
Chik B.H., Liu C.L., Fan S.T., Lo C.M., Poon R.T.P., Lam C.M. and Wong J., Tumor size and operative risks of extended right-sided hepatic resection for hepatocellular carcinoma: implication for preoperative portal vein embolization, Archives of Surgery. 2007, 142(1): 63-69. |
|
Chung M.F., Lam A.K.Y., Luk J.M.C., Law S.Y.K., Chan K.W., Lee P.Y. and Wong J., Clinical significance of e-cadherin and p120 catenin expression and localization in esophageal squamous cell carcinoma, 11th Research Postgraduate Symposium (11th RPS), The University of Hong Kong Li Ka Shing Faculty of Medicine, Hong Kong, 7 December. 2006. |
|
Fan S.T. and Wong J., Recurrent pyogenic cholangitis, Surgery of the Liver, Biliary Tract and Pancreas. 4th Edition. Philadelphia, Saunders Elsevier, 2006, 971-988. |
|
Jamieson G. and Wong J., Chapter 11: Small bowel resection; ileostomy; ileal pouches and the use of ileal conduits to replace the oesophagus: the anatomy of the small bowel, In: Jamieson G.G. (ed), The Anatomy of General Surgical Operations, Second Edition. USA, Churchill Livingstone, Elsevier, 2006, 56-60. |
|
Lai K.C., Chu K.M., Hui W.M., Wong B.C.Y., Hung W.K., Loo C.K., Hu H.C., Chan O.O., Kwok K.F., Fung T.T., Wong J. and Lam S.K., Esomeprazole with aspirin versus clopidogrel for prevention of recurrent gastrointestinal ulcer complications, Clinical Gastroenterology and Hepatology. 2006, 4: 860-865. |
|
Law S.Y.K. and Wong J., Chapter 63: Esophagogastrectomy for carcinoma of the esophagus and gastric cardia, and the esophageal anastomosis, In: Fischer J.E., Bland K.I., Callery M.P., Clagett G.P., Jones D.B., LoGerfo F.W. & Seeger J.M.(eds), Mastery of Surgery, Fifth Edition, Volume One. USA, Lippincott Williams & Wilkins, 2007, 752-771. |
|
Law S.Y.K. and Wong J., Chapter 9: Cancer of the esophagus, In: Zinner M.J.& Ashley S.W. (eds), Maingot's Abdominal Operations, Eleventh Edition. USA, The McGraw-Hill Company, Inc, 2007, 271-303. |
|
Law S.Y.K. and Wong J., Lymph node dissection in surgical treatment of esophageal neoplasms, Surgical Oncology Clinics of North America . 2007, 16(1): 115-131. |
|
Law S.Y.K., Chen C., Wong K.H., Tong K.H. and Wong J., Siewert type III gastroesophageal junction tumor is an independent poor prognostic factor (Abstract), 1st Asia-Pacific Gastric Cancer Conference, Department of Surgery, National University of Singapore, Singapore, 20-22 November 2006. |
|
Law S.Y.K., Kwong D.L.W., Wong K.H., Kwok K.F. and Wong J., The effects of neoadjuvant chemoradiation on pTNM staging and its prognostic significance in esophageal cancer, Journal of Gastrointestinal Surgery. 2006, 10(9): 1301-1311. |
|
Liu C.L., Fan S.T., Cheung S.T., Lo C.M., Ng I.O.L. and Wong J., Anterior approach versus conventional approach right hepatic resection for large hepatocellular carcinoma: a prospective randomized controlled study, Annals of Surgery. 2006, 244(2): 194-203. |
|
Liu C.L., Fan S.T., Lo C.M., Tso W.K., Lam C.M. and Wong J., Improved operative and survival outcomes of surgical treatment for hilar cholangiocarcinoma, British Journal of Surgery. 2006, 93(12): 1488-1494. |
|
Lo C.M., Liu C.L., Chan S.C., Lam C.M., Poon R.T.P., Ng I.O.L., Fan S.T. and Wong J., A randomized, controlled trial of postoperative adjuvant interferon therapy after resection of hepatocellular carcinoma, Annals of Surgery. 2007, 245(6): 831-842. |
|
Lo C.M., Lau G., Chan S.C., Fan S.T. and Wong J., Efficacy of a pre-S containing vaccine in patients receiving lamivudine prophylaxis after liver transplantation for chronic hepatitis B, American Journal of Transplantation. 2007, 7(2): 434-439. |
|
Lo C.M., Fan S.T., Liu C.L., Chan S.C., Ng I.O.L. and Wong J., Living donor versus deceased donor liver transplantation for early unresectable hepatocellular carcinoma, British Journal of Surgery. 2007, 94(1): 78-86. |
|
Luo Y., Lo C.M., Cheung C.K.Y., Lau G., Fan S.T. and Wong J., Identification of hepatitis B virus-specific lymphocytes in human liver grafts from HBV-immune donors, Liver Transplantation. 2007, 13(1): 71-79. |
|
Poon R.T.P., Fan S.T., Lo C.M., Liu C.L. and Wong J., Difference in tumor invasiveness in cirrhotic patients with hepatocellular carcinoma fulfilling the Milan criteria treated by resection and transplantation: impact on long-term survival, Annals of Surgery. 2007, 245(1): 51-58. |
|
Poon R.T.P., Fan S.T., Lo C.M., Ng K.K.C., Yuen W.K., Yeung C. and Wong J., External drainage of pancreatic duct with a stent to reduce leakage rate of pancreaticojejunostomy after pancreaticoduodenectomy: a prospective randomized trial (Abstract), Annual Meeting of American Surgical Association, Colorado Springs, USA, 26 - 28 April 2007. |
|
Tang W.K., Chui C.H., Fatima S., Kok S.H., Pak K.C., Ou T.M., Hui K.S., Wong M.M., Wong J., Law S.Y.K., Tsao G.S.W., Lam K.Y., Beh P.S., Srivastava G., Ho K.P., Chan A.S. and Tang J.C.O., Inhibitory effects of gleditsia sinensis fruit extract on telomerase activity and oncogenic expression in human esophageal squamous cell carcinoma, International Journal of Molecular Medicine. 2007, 19(6): 953-960. |
|
Tang W.K., Chui C.H., Fatima S., Kok S.H., Pak K.C., Ou T.M., Hui K.S., Wong M.M., Wong J., Law S.Y.K., Tsao G.S.W., Lam K.Y., Beh P.S., Srivastava G., Chan A.S., Ho K.P. and Tang J.C.O., Oncogenic properties of a novel gene JK-1 located in chromosome 5p and its overexpression in human esophageal squamous cell carcinoma, International Journal of Molecular Medicine. 2007, 19(6): 915-923. |
|
Wang X., Luk J.M.C., Garcia-Barcelo M.M., Miao X., Leung P.L., Ho D.W.Y., Cheung S.T., Lam B.Y.H., Cheung C.K.Y., Wong S.Y., Lau S.S.M., So M.T., Yu W.C., Cai Q., Liu K.S.Y., Hui C.K., Lau G., Poon R.T.P., Wong J. and Fan S.T., Liver intestine-cadherin (CDH17) haplotype is associated with increased risk of hepatocellular carcinoma, Clinical Cancer Research. 2006, 12(17): 5248-5252. |
|
Wong J., 25 years of esophageal cancer - the international view, Postgraduate Seminar "25 Years Surgery of the Upper GI-Tract - Retrospectives & Perspectives", Munich, Germany, 12 March. 2007. |
|
Wong J., Esophageal cancer, east and west: same name, difference disease, Asia Medical Forum, The Lancet 2007, Singapore, 21 April. 2007. |
|
Wong J., Honorary Medal, The Royal College of Surgeons of England, United Kingdom, 8 May 2007. 2007. |
|
Wong J. and Law S.Y.K., Interdisciplinary management of cancer: the surgical perspective (Abstract), UICC World Cancer Congress 2006, Washington, DC, U.S.A., 8 - 12 July 2006 . 2006. |
|
Wong J., Medical education in Hong Kong, Technical University of Munich, Munich, Germany, 21 December. 2006. |
|
Wong J., Multidisciplinary treatment in esophageal cancer: the price of failure, Annual Scientific Meeting of Malaysian Society of Gastroenterology and Hepatology - Malaysian Society Orator, Kuala Lumpur, Malaysia, 20-23 July. 2006. |
|
Wong J., Multidisciplinary treatment in esophageal cancer: the price of failure, Humboldt University of Berlin, Berlin, Germany, 24 October. 2006. |
|
Wong J., Preventing, diagnosing and treating oesophageal anastomotic leaks, 9th Bill Owen Oesophago-Gastric Symposium, Royal College of Surgeons of England, London, United Kingdom, 9 March. 2007. |
|
Wong J., Progress in multidisciplinary cancer treatment, Humboldt University of Berlin, Berlin, Germany, 24 October. 2006. |
|
Wong J., Resection of gastrointestinal cancer: in search of perfection, International Symposium in honor of Professor Masaki Kitajima, Tokyo, Japan, 24 March. 2007. |
|
Wong J., Technical detail of oesophagectomy with gastric and colonic interposition (Video Presentation), 9th Bill Owen Oesophago-Gastric Symposium, Royal College of Surgeons of England, London, United Kingdom, 9 March. 2007. |
|
Wong J., The epidemiology and management of esophageal cancer, Department of Surgery, Melaka Medical College, Melaka, Malaysia, 23 July. 2006. |
|
Wong J., Treatment of esophageal cancer: the price of failure, Technical University of Munich, Munich, Germany, 21 December. 2006. |
|
Wong J., Treatment of esophageal cancer: the price of failure, William Marsden Lecture, Royal Marsden Hospital, London, United Kingdom, 22 March. 2007. |
|
Wong J. and Law S.Y.K., Two approaches to cancer of the cardia, The Lancet Oncology. 2006, 7(8): 613-615. |
|
Researcher
: Wong KH |
|
List of Research Outputs |
|
Cense H.A., Law S.Y.K., Wei W.I., Lam L.K., Ng W.M., Wong K.H., Kwok K.F. and Wong J., Pharyngolaryngoesophagectomy using the thoracoscopic approach, Surgical Endoscopy. 2007, 21(6): 879-884. |
|
Cense H.A., Law S., Wei W.I., Lam L.K., Ng W.M., Wong K.H., Kwok K.F. and Wong J., Surg Endosc, Pharyngolaryngoesophagectomy using the thoracoscopic approach. 2007, 21: 879-884. |
|
Researcher
: Wong KKY |
|
List of Research Outputs |
|
Bugeon L., Wong K.K.Y., Rankin A.M., Hargreaves R.E. and Dallman M.J., A Negative Regulatory Role In Mouse Cardiac Transplantation For A Splice Variant Of Cd80, Transplantation. 2006, 82 (10): 1334-1341. |
|
Chan D.T.I., Wong K.K.Y. and Tam P.K.H., Spontaneous pneumoperitoneum after pneumonia in a child., Journal of Paediatrics and Child Health. 2007, 43(1): 85-86. |
|
Chan H.Y., Wong K.K.Y., Lan L.C.L. and Tam P.K.H., The use of MRI in helping sex determination decision making for intersex patients, The 40th Annual Meeting of the Pacific Association of Paediatric Surgeons together with the Annual Scientific Meeting of the Australasian Association of Paediatric Surgeons, Queenstown, New Zealand, 15-19 April 2007. |
|
Miao X., Garcia-Barcelo M.M., So M.T., Leon Y.Y., Lau K.C., Liu T., Chan E.K.W., Lan L.C.L., Wong K.K.Y., Lui V.C.H. and Tam P.K.H., Role of RET and PHOX2B gene polymorphisms in risk of Hirschsprung's disease in Chinese population, Gut. 2007, 56(5): 736. |
|
Ngan E.S.W., Sit Y.L.F., Lee K.Y., Miao X., Yuan Z., Wang W.L., Nicholls J.M., Wong K.K.Y., Garcia-Barcelo M.M., Lui V.C.H. and Tam P.K.H., Implications of endocrine gland - derived vascular endothelial growth factor/prokineticin-1 signaling in human neuroblastoma progression., Clinical Cancer Research. 2007, 13(3): 868-875. |
|
Tam P.K.H., Wong K.K.Y. and Lan L.C.L., The impact of laparoscopic appendicectomy on pediatric surgical training, 20th Congress of Asian Association of Pediatric Surgeons (AAPS) with WOFAPS Executive Meeting, New Delhi, India, 12-15 November 2006. |
|
Tian J., Wong K.K.Y., Ho C.M., Lok C.N., Yu W.Y., Che C.M., Chiu J. and Tam P.K.H., Topical delivery of silver nanoparticles promotes wound healing, ChemMedChem. 2007, 2: 129-136. |
|
Wong K.K.Y., Development of nanomedicine in Hong Kong, American Academy of Nanomedicine, 9 September 2006. 2006. |
|
Wong K.K.Y., Development of nanomedicine in Hong Kong, The 2nd Annual Meeting of American Academy of Nanomedicine, Washington DC, U.S.A., 9-10 September 2006. |
|
Wong K.K.Y., Foo D., Lan L.C.L. and Tam P.K.H., Is prenatal diagnosis of choledochal cysts beneficial?, The 40th Annual Meeting of the Pacific Association of Paediatric Surgeons together with the Annual Scientific Meeting of the Australasian Association of Paediatric Surgeons, Queenstown, New Zealand, 15-19 April 2007. |
|
Wong K.K.Y., Laparoscopic anorectoplasty - the new gold standard for patients with imperforate anus, Shenzhen Children Hospital, China, 22 January 2007. 2007. |
|
Wong K.K.Y., Laparoscopic approaches to paediatric inguinal hernias [Invited Lecture], 1st SK Yee Medical Foundation Laparoscopic Workshop, Beijing, China, 21-24 June 2007. 2007. |
|
Wong K.K.Y., Fang C.X. and Tam P.K.H., Selective upper endoscopy for foreign body ingestion in children: an evaluation of management protocol after 282 cases, Journal of Pediatric Surgery. 2006, 41 (12): 2016-2018. |
|
Wong K.K.Y., Leung K.H., Lan L.C.L., Tam P.K.H. and Chan H.Y., The impact of antenatal diagnosis on small bowel atresia revisited, The 40th Annual Meeting of the Pacific Association of Paediatric Surgeons together with the Annual Scientific Meeting of the Australasian Association of Paediatric Surgeons, Queenstown, New Zealand, 15-19 April 2007. |
|
Wong K.K.Y., Topical delivery of silver nanoparticles reduces systemic inflammation of burn and promotes wound healing, 2nd Annual meeting of the American Academy of Nanomedicine, Washington DC, U.S.A., 8 September 2006. |
|
Wong K.K.Y., Tian J., Ho C.M., Lok C.N., Che C.M., Chiu J. and Tam P.K.H., Topical delivery of silver nanoparticles reduces systemic inflammation of burn and promotes wound healing, Nanomedicine : nanotechnology, biology, and medicine. 2006, 2(4): 306. |
|
Researcher
: Wong SY |
|
List of Research Outputs |
|
Wang X., Luk J.M.C., Garcia-Barcelo M.M., Miao X., Leung P.L., Ho D.W.Y., Cheung S.T., Lam B.Y.H., Cheung C.K.Y., Wong S.Y., Lau S.S.M., So M.T., Yu W.C., Cai Q., Liu K.S.Y., Hui C.K., Lau G., Poon R.T.P., Wong J. and Fan S.T., Liver intestine-cadherin (CDH17) haplotype is associated with increased risk of hepatocellular carcinoma, Clinical Cancer Research. 2006, 12(17): 5248-5252. |
|
Researcher
: Xiao J |
|
List of Research Outputs |
|
Man K., Xiao J., Ng T.P., Cheng Q., Sun B., Wang Y., Sun K.W., Poon R.T.P. and Lo C.M., Adiponectin as a novel therapy for the suppression of the liver cancer growth and metastasis (Paper Presentation), the 14th European Organisation for the Research and Treatment of Cancer, National Cancer Institute, and American Association for Cancer Research (EORTC-NCI-AARC) Symposium on Molecular Targets and Cancer Therapeutics, Prague, Czech Republic, 7 - 10 November 2006. European Journal of Cancer Supplement. 2006, 50. |
|
Man K., Xiao J., Ng T.P., Cheng Q., Sun K.W., Lo C.M., Poon R.T.P. and Fan S.T., Combination therapy for liver tumor growth and metastasis by low dose rapamycin and FTY720 (Paper Presentation), the 14th European Organisation for the Research and Treatment of Cancer, National Cancer Institute, and American Association for Cancer Research (EORTC-NCI-AARC) Symposium on Molecular Targets and Cancer Therapeutics, Prague, Czech Republic, 7 - 10 November 2006. |
|
Man K., Lo C.M., Xiao J., Ng T.P., Sun K.W., Wang Y. and Fan S.T., The significance of acute phase graft injury on tumor recurrence/metastases in live donor liver transplantation (Abstract), World Transplant Congress 2006, Boston, U.S.A., 22 -27 July 2006. |
|
Man K., Lo C.M., Xiao J., Ng T.P., Sun K.W., Wang Y. and Fan S.T., The significance of graft size on tumor recurrence after liver transplantation - activation of cell invasion pathway (Abstract), World Transplant Congress 2006, Boston, U.S.A., 22 - 27 July 2006. |
|
Shih K.C., Man K., Ng T.P., Xiao J., Fan S.T. and Lo C.M., Distinct gene signatures linked to acute phase injury and tumor invasiveness in tumor development after liver transplantation using small-for-size grafts (Abstract), The International Liver Transplantation Society 13th Annual International Congress, Rio de Janeiro, Brazil, 20 - 23 June 2007. |
|
Shih K.C., Man K., Ng T.P., Xiao J., Fan S.T. and Lo C.M., Rising Star Award - "Distinct gene signatures linked to acute phase injury and tumor invasiveness in tumor development after liver transplantation using small-for-size grafts", The International Liver Transplantation Society 13th Annual International Congress, Rio de Janeiro, Brazil, 20 - 23 June 2007. 2007. |
|
Researcher
: Xie Y |
|
List of Research Outputs |
|
Ren Y., Xie Y., Chan H.M. and Tam P.K.H., Visinin like protein 1 (VILIP-1) enhances neuroblastoma cell migration, 53rd Annual International Congress of the British Association of Paediatric Suregons, Stockholm, Sweden, 18-21 July 2006. |
|
Xie Y., Metastasis and angiogenesis in neuroblastoma: involvement of visinin like protein-1 and dendritic cell, Thesis, Doctor of Philosophy, The University of Hong Kong. 2007. |
|
Researcher
: Xu R |
|
Project Title: |
Oral gene therapy of tumors by using recombinant AAV-TRAIL viral vectors |
|
Investigator(s): |
Xu R, Kung H |
|
Department: |
Institute of Molecular Biology |
|
Source(s) of Funding: |
Matching Fund for Hi-Tech Research and Development Program of China (863 Projects) |
|
Start Date: |
05/2002 |
|
Abstract: |
|
To study tumor therapy by using recombinant AAV. |
|
Project Title: |
Peroral transduction of hepatocytes for diabetes gene therapy |
|
Investigator(s): |
Xu R, Lam KSL |
|
Department: |
Institute of Molecular Biology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
10/2002 |
|
Abstract: |
|
A major goal of gene therapy for Diabetes Mellitus (DM) is to restore long-term euglycemia. This study shall focus on clarifying the adeno-associated virus (AAV) vector transportation pathway from stomach to liver after oral administration. The research team will extend their previous study further to develop chimeric glucose- and insulin-sensitive promoters and insert them into the existing AAV vector system. |
|
Project Title: |
Preclinical study of lung cancer therapy using recombinant adeno-associate virus vector |
|
Investigator(s): |
Xu R |
|
Department: |
Institute of Molecular Biology |
|
Source(s) of Funding: |
Matching Fund for Hi-Tech Research and Development Program of China (863 Projects) |
|
Start Date: |
04/2003 |
|
Abstract: |
|
To carrry out preclinical study of lung cancer therapy using recombinant adeno-associate virus vector. |
|
List of Research Outputs |
|
Researcher
: Yang Z |
|
Project Title: |
Combination of mTOR inhibitor with chemo-cytotoxic agent for the treatment of hepatocellular carcinoma |
|
Investigator(s): |
Yang Z, Poon RTP |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
01/2006 |
|
Completion Date: |
12/2006 |
|
Abstract: |
|
Objective: Hepatocellular carcinoma (HCC) ranks fifth in frequency worldwide among all malignancies and causes one million deaths annually. Hepatic resection and liver transplantation are the only two approaches that may cure HCC, but the majority of patients present with an advanced stage beyond surgical treatment. Chemotherapy is widely employed to treat unresectable HCC, but the efficacy is not satisfactory due to the resistance of tumor cells to the chemo-cytotoxic agents. The mammalian target of rapamycin (mTOR) has been demonstrated to play an important role in the chemo-resistant pathways in some tumors. Therefore, we design the present study to evaluate the therapeutic potential of mTOR inhibition on enhancement of chemo-sensitivity of HCC tumor cells to chemo-cytotoxic agents. |
|
Project Title: |
Blockade of BDNF-TrkB pathway as a novel anti-angiogenic therapy for HCC |
|
Investigator(s): |
Yang Z, Poon RTP |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
05/2007 |
|
Abstract: |
|
Hepatocellular carcinoma (HCC) is the second most common cause of cancer death in Hong Kong. As HCC is a highly vascularized solid tumor in which angiogenesis plays a crucial role, exploring the mechanisms of tumor angiogenesis may lead to a novel therapy for this cancer. A recent study by the investigators has identified brain-derived neurotrophic factor (BDNF) in serially collected serum samples during tumor development in a rat orthotopic HCC model (1). By immunohistochemical staining, it was found that BDNF was expressed not only in tumor cells, but also in endothelial cells in the tumor tissue, suggesting its potential role in tumor angiogenesis. In addition, others’ studies have shown that BDNF activation of its receptor, tyrosine kinase B (TrkB), promotes angiogenic properties and survival of endothelial cells (2,3), and upregulates the expression of vascular endothelial growth factor (VEGF), which is one of the most potent angiogenic factors (4). Based on the above findings, we hypothesize that BDNF may play a crucial role in tumor angiogenesis of HCC, through its interaction with TrkB. Therefore, we propose the present study to explore the possible effects of BDNF on the angiogenic behaviors of endothelial cells by administration of exogenous BDNF to the endothelial cells in vitro. In addition, the therapeutic potential of blockade of BDNF-TrkB interaction as a novel anticancer approach will also be studied in vivo in a mouse HCC model. |
|
List of Research Outputs |
|
Ho D.W.Y., Yang Z., Wong B.Y.H., Kwong D.L.W., Sham J.S.T., Wei W.I. and Yuen P.W., Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry serum protein profiling to identify nasopharyngeal carcinoma, Cancer. 2006, 107(1): 99-107. |
|
Ho
D.W.Y., Yang Z., Lau C.K., Tam K.H., To J.Y.T., Poon R.T.P. and Fan S.T., Therapeutic potential of
cardiotrophin |
|
Ho W.K., Yang Z., Wong B.Y., Kwong D.L.W., Sham J.S.T., Wei W.I. and Yuen P.W., Cancer, Surface-enhanced laser desorption / ionization time-of-flight mass spectrometry serum protein profiling to identify nasopharyngeal carcinoma. 2006, 107: 99-107. |
|
Lam C.T., Yang Z., Ngai P.P., Fan S.T. and Poon R.T.P., The potential role of brain-derived neurotrophic factor (BDNF) in angiogenesis (Poster Presentation), The 2nd European Conference on Tumor Angiogenesis and Antiangiogenic Therapy (ECTA), Munich, Germany, 14 - 16 September 2006. |
|
Lam C.T., Yang Z., Fan S.T. and Poon R.T.P., The potential role of brain-derived neurotrophic factor (BDNF) in angiogenesis (Poster Presentation), The 98th Annual Meeting of the American Association for Cancer Research, Los Angeles, USA, 14 - 18 April 2007. |
|
Lau
C.K., Yang Z., Ngai P.P., Poon R.T.P. and Fan S.T., HIF |
|
Lau
C.K., Yang Z., Poon R.T.P. and Fan S.T., HIF |
|
Lau C.K., Yang Z., Lam C.T., Tam P.K.H., Poon R.T.P. and Fan S.T., Suppression of hypoxia inducible factor-1a (HIF-1a) by YC-1 is dependent on murine double minute 2 (MDM2), Biochemical and Biophysical Research Communications. 2006, 348(4): 1443-1448. |
|
Lee K.W., Poon R.T.P., Yuen P.W., Man K., Yang Z., Guan X.Y. and Fan S.T., Rac activation is associated with hepatocellular carcinoma metastasis by up-regulation of vascular endothelial growth factor expression, Clinical Cancer Research. 2006, 12(17): 5082-5089. |
|
Lee T.K., Poon R.T.P., Yuen P.W., Man K., Yang Z., Guan X.Y. and Fan S.T., Clin Cancer Res, Rac activation is associated with hepatocellular carcinoma metastasis by up-regulation of vascular endothelial growth factor expression. 2006, 12: 5082-9. |
|
Lin
M.C., Shen Z., Yang Z., Fan S.T. and Kung H.F., Kringle 1 Domain
of Human Hepatocyte Growth Factor (HGFK1) Inhibits The Growth and Metastasis
of Hepatocellular Carcinoma in Rats, MGH-HKU-Nature Forum, The |
|
Poon R.T.P., Tam K.H., Yang Z. and Fan S.T., Both p53 dependent and independent pathways contribute to RAD001 mediated enhancement of chemo-sensitivity in hepatocellular carcinoma (Poster Presentation), The 98th Annual Meeting of the American Association for Cancer Research, Los Angeles, USA, 14 - 18 April 2007. |
|
Shen Z., Yang Z., Gao Y., Poon R.T.P., Fan S.T., He M.L., Li T.P., Gan R.B., Kung H.F. and Lin M.C., Kringle 1 Domain of Human Hepatocyte Growth Factor (HGFK1) Inhibits the Growth and Metastasis of Hepatocellular Carcinoma in Rats, 10th Annual Meeting of the American Society of Gene Therapy, May 30-June 3, 2007, at the Washington State Convention and Trade Center in Seattle, WA. 2007. |
|
Shen Z., Yang Z., Gao Y., Liu C.C., Ng S.M., Fan S.T., Li T.P., Gan R.B., He M.L., Kung H.F. and Lin M.C., Sustained Expression of Kringle 1 Domain of HGF (HGFK1) Effectively Inhibits Hepatocellular Carcinoma Tumor Growth and Metastasis by a Novel Mechanism, 2006 ISCGT Japan Conference, Chiba, Japan, October 13-15, 2006. |
|
Tam
K.H., Yang Z. and Poon R.T.P., Inhibition of mTOR by
RAD001 enhances chemo-sensitivity of hepatocellular carcinoma (HCC) (Oral
Presentation), The 13th Hong Kong International Cancer Congress, |
|
Tam K.H., Yang Z. and Poon R.T.P., Young Investigator Award - "Inhibition of mTOR by RAD001 enhances chemo-sensitivity of hepatocellular carcinoma (HCC)", The 13th Hong Kong International Cancer Congress, Hong Kong, 15 - 17 August 2006. 2006. |
|
Yang Z., Ho D.W.Y., Ngai P.P., Lau C.K., Zhao Y., Poon R.T.P. and Fan S.T., Antiinflammatory properties of IL-10 rescue small-for-size liver grafts, Liver Transplantation. 2007, 13(4): 558-565. |
|
Yang Z., Poon R.T.P., Liu Y., Lau C.K., Ho D.W.Y., Tam K.H., Lam C.T. and Fan S.T., High doses of tyrosine kinase inhibitor PTK787 enhance the efficacy of ischemic hypoxia for the treatment of hepatocellular carcinoma: dual effects on cancer cell and angiogenesis, Molecular Cancer Therapeutics. 2006, 5(9): 2261-2270. |
|
Yang Z., Lau C.K., Ngai P.P., Ho D.W.Y., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Induction of long-term liver allograft survival by delayed immunosuppression is dependent on interleukin-10 (Oral Presentation), World Transplant Congress 2006, Boston, U.S.A., 22 - 27 July 2006. |
|
Yang Z., Ngai P.P., Lau C.K., Ho D.W.Y., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Induction of long-term liver allograft survival by delayed immunosuppression is dependent on interleukin-10, Liver Transplantation. 2007, 13(4): 571-578. |
|
Yang Z., Member of Editorial Board, Open Transplantation Journal. 2007. |
|
Yang Z., Ho D.W.Y., Lau C.K., Tam K.H., Lam C.T., Poon R.T.P. and Fan S.T., Platelet activation during tumor development, the potential role of BDNF-TrkB autocrine loop, Biochemical and Biophysical Research Communications. 2006, 346(3): 981-985. |
|
Yang Z., Ho D.W.Y., Lau C.K., Tam K.H., Lam C.T., Yu W.C., Poon R.T.P. and Fan S.T., Significance of the serum brain-derived neurotrophic factor and platelets in hepatocellular carcinoma, Oncology Reports. 2006, 16(6): 1237-1243. |
|
Yang
Z., The many faces of the NGF family in
cancer (Invited Lecture), Frontier of Biomedical Research, The |
|
Researcher
: Yang ZF |
|
Project Title: |
Combination of mTOR inhibitor with chemo-cytotoxic agent for the treatment of hepatocellular carcinoma |
|
Investigator(s): |
Yang Z, Poon RTP |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
01/2006 |
|
Completion Date: |
12/2006 |
|
Abstract: |
|
Objective: Hepatocellular carcinoma (HCC) ranks fifth in frequency worldwide among all malignancies and causes one million deaths annually. Hepatic resection and liver transplantation are the only two approaches that may cure HCC, but the majority of patients present with an advanced stage beyond surgical treatment. Chemotherapy is widely employed to treat unresectable HCC, but the efficacy is not satisfactory due to the resistance of tumor cells to the chemo-cytotoxic agents. The mammalian target of rapamycin (mTOR) has been demonstrated to play an important role in the chemo-resistant pathways in some tumors. Therefore, we design the present study to evaluate the therapeutic potential of mTOR inhibition on enhancement of chemo-sensitivity of HCC tumor cells to chemo-cytotoxic agents. |
|
Project Title: |
Blockade of BDNF-TrkB pathway as a novel anti-angiogenic therapy for HCC |
|
Investigator(s): |
Yang Z, Poon RTP |
|
Department: |
Surgery |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
05/2007 |
|
Abstract: |
|
Hepatocellular carcinoma (HCC) is the
second most common cause of cancer death in |
|
List of Research Outputs |
|
Researcher
: Yau TO |
|
Project Title: |
The role of Frizzled-7, receptor of the WNT/β-catenin signalling pathway, in hepatocellular carcinoma: Implications in tumorigenesis and metastasis |
|
Investigator(s): |
Yau TO, Ng IOL |
|
Department: |
Pathology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
10/2006 |
|
Abstract: |
|
Hepatocellular carcinoma (HCC) is second
commonest in Asia and in |
|
List of Research Outputs |
|
Researcher
: Yeung C |
|
List of Research Outputs |
|
Chan A., Poon R.T.P., Mh K.C., Chan S.C., Yuen W.K., Yeung C., Lo C.M. and Fan S.T., Effect of changing paradigm for management of hepatocellular carcinoma on the long-term survival of patients with hepatocellular carcinoma (Abstract), The 1st Biennial Congress of the Asian-Pacific Hepato-Pancreato-Biliary Association, Fukuoka, Japan, 20 - 23 March 2007. |
|
Poon R.T.P., Fan S.T., Lo C.M., Ng K.K.C., Yuen W.K., Yeung C. and Wong J., External drainage of pancreatic duct with a stent to reduce leakage rate of pancreaticojejunostomy after pancreaticoduodenectomy: a prospective randomized trial (Abstract), Annual Meeting of American Surgical Association, Colorado Springs, USA, 26 - 28 April 2007. |
|
Researcher
: Yi X |
|
List of Research Outputs |
|
Luk
J.M.C., Yi X. and Fan S.T., Mitochondrial heat shock
protein 75 9MTHSP75) is a predictive marker for early tumor recurrence in
hepatocellular carcinoma (Abstract), Hepatology. 2006, 44(4): |
|
Luk J.M.C., Yi X., Lee P.Y., Guan X.Y., Lau G. and Fan S.T., Mortalin-2 is an accurate prognostic biomarker for early recurrence of liver carcinoma (Abstract), The 17th Asian Pacific Association for the Study of the Liver Conference, Kyoto, Japan, 27 - 30 March 2007. Hepatology International. 2007, 1(1): 68. |
|
Researcher
: Yip AWC |
|
List of Research Outputs |
|
Ho K.L., Yip A.W.C., Leung L.S. and Law I.C., Surgical treatment of penile curvature, Hong Kong Medical Journal. 2006, 12(6): 410-414. |
|
Researcher
: Yiu WK |
|
List of Research Outputs |
|
Chan Y.C., Ting A.C.W., Ho P., Poon J.T.C., Yiu W.K. and Cheng S.W.K., Supra-aortic hybrid endovascular procedures for complex thoracic aortic disease (Best Paper Session), Conjoint Scientific Congress of the Royal College of Surgeons of England and the College of Surgeons of Hong Kong, Hong Kong, 6-7 May 2007. |
|
Chan Y.C., Ting A.C.W., Poon J.T.C., Yiu W.K., Cheung G.C.Y. and Cheng S.W.K., Ten year epidemiological review of in-hospital patients with Marfan syndrome, Conjoint Scientific Congress of the Royal College of Surgeons of England and the College of Surgeons of Hong Kong, Hong Kong, 6-7 May 2007. |
|
Kwong A., Yiu W.K., Chow L.W.C. and Wong S., Chrysomya Bezziana: an unusual infestation of the breast, The Breast Journal. 2007, 13(3): 297-301. |
|
Kwong A., Yiu W.K., Chow L.W.C. and Wong S.S.Y., Chrysomya bezziana: a rare infestation of the breast., The Breast Journal. 2007, 13: 297-301. |
|
Yiu W.K., Cheng S.W.K. and Sumpio B.E., Vascular smooth muscle cell apoptosis induced by "supercooling and rewarming, Journal of Vascular and Interventional Radiology. 2006, 17(12): 1971-1977. |
|
Researcher
: Yu WC |
|
List of Research Outputs |
|
Ho J.W.Y., Pang R.W.C., Lau C.P.Y., Sun K.W., Yu W.C., Fan S.T. and Poon R.T.P., Significance of circulating endothelial progenitor cells in hepatocellular carcinoma, Hepatology. 2006, 44(4): 836-843. |
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Lau C.P., Poon R.T.P., Cheung S.T., Yu W.C. and Fan S.T., SPARC and Hevin expression correlate with tumour angiogenesis in hepatocellular carcinoma, Journal of Pathology. 2006, 210(4): 459-468. |
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Wang X., Luk J.M.C., Garcia-Barcelo M.M., Miao X., Leung P.L., Ho D.W.Y., Cheung S.T., Lam B.Y.H., Cheung C.K.Y., Wong S.Y., Lau S.S.M., So M.T., Yu W.C., Cai Q., Liu K.S.Y., Hui C.K., Lau G., Poon R.T.P., Wong J. and Fan S.T., Liver intestine-cadherin (CDH17) haplotype is associated with increased risk of hepatocellular carcinoma, Clinical Cancer Research. 2006, 12(17): 5248-5252. |
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Yang Z., Ho D.W.Y., Lau C.K., Tam K.H., Lam C.T., Yu W.C., Poon R.T.P. and Fan S.T., Significance of the serum brain-derived neurotrophic factor and platelets in hepatocellular carcinoma, Oncology Reports. 2006, 16(6): 1237-1243. |
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Researcher
: Yuan Z |
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List of Research Outputs |
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Chen Y., Liu Y., Yuan Z., Tian L., Dallman M.J., Thompson P.W., Tam P.K.H. and Lamb J.R., Rosiglitazone suppresses cyclosporin-induced chronic transplant dysfunction and prolongs survival of rat cardiac allografts, Transplantation. 2007, 83(12): 1602-1610. |
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Ngan E.S.W., Sit Y.L.F., Lee K.Y., Miao X., Yuan Z., Wang W.L., Nicholls J.M., Wong K.K.Y., Garcia-Barcelo M.M., Lui V.C.H. and Tam P.K.H., Implications of endocrine gland - derived vascular endothelial growth factor/prokineticin-1 signaling in human neuroblastoma progression., Clinical Cancer Research. 2007, 13(3): 868-875. |
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Researcher
: Yuen PW |
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Project Title: |
The identification of proteomic tumor marker of upper aerodigestive tract squamous cell carcinoma |
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Investigator(s): |
Yuen PW, He Q, Chiu J |
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Department: |
Surgery |
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Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
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Start Date: |
09/2003 |
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Completion Date: |
08/2006 |
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Abstract: |
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To identify the proteomic tumor markers of UADTSCC that are differentially expressed in both UADTSCC primary tumor and sera of patients. These differentially expressed proteins can provide information on the molecular mechanism of carcinogenesis of UADTSCC and may also be used clinically for screening of cancer and monitoring recurrence after treatment. |
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Project Title: |
The evaluation of the clinical application of hypermethylated promoter DNA as tumor marker of nasopharyngeal carcinoma |
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Investigator(s): |
Yuen PW, Kwong DLW |
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Department: |
Surgery |
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Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
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Start Date: |
01/2005 |
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Abstract: |
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To identify the genes that are frequently methylated in NPC tumor and can be used as tumor marker in body fluids of blood, nasopharyngeal swab and throat rinsing fluid for the screening of primary NPC and residual NPC after treatment. |
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Project Title: |
The evaluation of the clinical application of hypermethylated DNA as tumor marker in body fluids for screening of primary and recurrent nasopharyngeal carcinoma |
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Investigator(s): |
Yuen PW, Sham JST, Kwong DLW, Wei WI |
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Department: |
Surgery |
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Source(s) of Funding: |
Michael Kadoorie Cancer Genetics Research Fund |
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Start Date: |
01/2005 |
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Abstract: |
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To identify genes that are specifically and frequently methylated in NPC; to evaluate the sensitivity and specificity of screening primary and recurrent NPC in body fluids of peripheral blood, nasopharyngeal swab and throat rinsing fluid using methylated DNA as tumor marker. |
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Project Title: |
The evaluation of therapeutic application of demethylation of oral tongue carcinoma |
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Investigator(s): |
Yuen PW |
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Department: |
Surgery |
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Source(s) of Funding: |
Small Project Funding |
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Start Date: |
09/2005 |
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Abstract: |
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Background:Methylation of the CG rich promoter region and histone deacethylation of many genes particularly tumor suppressor genes have been found to be common epigenetic abnormalities in many cancers including oral tongue carcinoma. Genes that are silenced due to promoter methylation can be reactivated by demethylating agents. Since gene expression profile is directly related to cellular properties, re-expression of silenced genes will alter the biologic properties of cancer cells. Epigenetic therapy using demethylating agents have been shown to result in re-expression of silenced genes to induce apoptosis, killing of cancer cells, suppression of cell proliferation and modulation of many biologic properties of cancer cells including radiosensitivity and chemosensitivity. Demethylation therapy is a promising new modality of treatment option of cancer either alone or in combination with other treatment modalities. Many demethylating agents are available recently.I have found high frequencies of methylation of many tumor suppressor genes in head and neck carcinoma including oral tongue carcinoma. I have also shown that p15, p16 and E-cadherin methylation are found in aprarently normal oral mucosa of chronic smokers and drinkers. It indicates the presence of cancerization field changes induced by tobacco and alcohol. It therefore worths to evaluate the potential to reverse the methylation in field cancerization process of premailinant stages of carcinogenesis and also treat advanced, recurrent or metastatic head and neck carcinoma with demethylating agents. The therapeutic efficacy of various epigenetic therapeutic agents in reversing epigenetic changes in head and neck carcinoma either alone or in combination with other chemotherapeutic agents are still unknown. In view of the many compounds available for possible clinical trial as monotherapy and the large number of possible regimens in combination with conventional chemotherapy, a pre-clinical evaluation of therapeutic efficacy in cell lines and mice model is therefore necessary to resolve on the best possible regimens for experimental design of subsequent clinical trials. The aim of this study is to evaluate the therapeutic afficacy of various demethylating agents in tongue carcinoma. |
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Project Title: |
Molecular mechanisms of induction of apoptosis of curcumin on oral cancers |
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Investigator(s): |
Yuen PW |
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Department: |
Surgery |
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Source(s) of Funding: |
Small Project Funding |
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Start Date: |
09/2006 |
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Abstract: |
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Curcuma longa is a plant belongs to the family of Zingiberaceae. Curcuma longa is widely distributed in both tropical and subtropical regions. The dried rhizome of Curcuma longa has widely been used as dietary favoring and colouring agents (hallmark yellowish color). Curcuma longa has also been used as herbal medicine in treating wound and inflammation. Curcuminoids is one of the major polyphenols derived from the dried rhizome of Curcuma longa. Curcumin is one of the major curcuminoids isolated from Curcuma longa. Curcumin is a candidate chemopreventive agent due to its potent anti-inflammation and anti-oxidation effects. Curcumin also has anticancer effects in several human malignancies. Curcumin could contribute in hindering carcinogensis initiation, inhibiting cells proliferation and modulating the apoptotic pathways in cancer cells (Curcumin has been shown to have cytotoxic effect in cancer including oral cancer in cell lines. Curcumin is readily applicable locally to reach the required therapeutic concentration in oral cavity for chemoprevention and therapy. The present study aims at 1. evaluate whether there is any synergistic effect of curcumin in enahncing chemotherapeutic effect of conventional cytotoxic drugs for treatment of oral cancers including cisplatin, 5-FU and taxol. 2. study the molecular mechanims of curcumin in inducing apoptosis of oral cancers. |
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Project Title: |
The evaluation of the clinical application of hypermethylated promoter DNA as tumor marker for the early detection of surgically salvageable residual or recurrent head and neck squamous cell carcinoma after treatment |
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Investigator(s): |
Yuen PW, Wong TS |
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Department: |
Surgery |
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Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
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Start Date: |
10/2006 |
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Abstract: |
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(1) The primary tumors will be screened for presence of methylation using a panel of genes; (2) of those genes that are methylated in the primary tumors, the plasma will be evaluated again for concordant methylation both before treatment and after treatment; (3) the sensitivity and specificity of aberrantly methylated DNA as molecular markers in plasma for detection of surgically salvageable residual/recurrent HNSCC after curative surgical treatment will be calculated. |
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List of Research Outputs |
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Ho D.W.Y., Yang Z., Wong B.Y.H., Kwong D.L.W., Sham J.S.T., Wei W.I. and Yuen P.W., Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry serum protein profiling to identify nasopharyngeal carcinoma, Cancer. 2006, 107(1): 99-107. |
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Ho W.K., Yang Z., Wong B.Y., Kwong D.L.W., Sham J.S.T., Wei W.I. and Yuen P.W., Cancer, Surface-enhanced laser desorption / ionization time-of-flight mass spectrometry serum protein profiling to identify nasopharyngeal carcinoma. 2006, 107: 99-107. |
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Lee K.W., Poon R.T.P., Yuen P.W., Man K., Yang Z., Guan X.Y. and Fan S.T., Rac activation is associated with hepatocellular carcinoma metastasis by up-regulation of vascular endothelial growth factor expression, Clinical Cancer Research. 2006, 12(17): 5082-5089. |
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Lee K.W., Poon R.T.P., Yuen P.W., Ling M.T., Wang X., Wong Y.C., Guan X.Y., Man K., Tang Z.Y. and Fan S.T., Regulation of angiogenesis by Id-1 through hypoxia-inducible factor-1 mediated vascular endothelial growth factor up-regulation in hepatocellular carcinoma, Clinical Cancer Research. 2006, 12(23): 6910-6919. |
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Lee K.W., Man K., Poon R.T.P., Lo C.M., Yuen P.W., Ng I.O.L., Ng T.P., Leonard W. and Fan S.T., Signal transducers and activators of transcription 5b activation enhances hepatocellular carcinoma aggressiveness through induction of epithelial-mesenchymal transition, Cancer Research. 2006, 66(20): 9948-9956. |
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Lee K.W., Poon R.T.P., Yuen P.W., Ling M.T., Kwok W.K., Wang X., Wong Y.C., Guan X.Y., Man K., Chau K.L. and Fan S.T., Twist overexpression correlates with hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition, Clinical Cancer Research. 2006, 12(18): 5369-5376. |
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Lee T.K., Man K., Poon R.T.P., Lo C.M., Yuen P.W., Ng I.O., Ng K.T., Leonard W. and Fan S.T., Cancer Res., Signal transducers and activators of transcription 5b activation enhances hepatocellular carcinoma aggressiveness through induction of epithelial-mesenchymal transition. 2006, 66: 9948-56. |
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Lee T.K., Poon R.T.P., Yuen P.W., Ling M.T., Kwok W.K., Wang X.H., Wong Y.C., Guan X.Y., Man K., Chau K.L. and Fan S.T., Clin Cancer Res., Twist overexpression correlates with hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition. 2006, 12: 5369-76. |
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Lee T.K., Poon R.T.P., Yuen P.W., Man K., Yang Z., Guan X.Y. and Fan S.T., Clin Cancer Res, Rac activation is associated with hepatocellular carcinoma metastasis by up-regulation of vascular endothelial growth factor expression. 2006, 12: 5082-9. |
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Lee T.K., Poon R.T.P., Yuen P.W., Ling M.T., Wang X.H., Wong Y.C., Guan X.Y., Man K., Tang Z.Y. and Fan S.T., Clin Cancer Res, Regulation of angiogenesis by Id-1 through hypoxia-inducible factor-1alpha-mediated vascular endothelial growth factor up-regulation in hepatocellular carcinoma. 2006, 12: 6910-9. |
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Li H.M., Man C., Jin Y., Deng W., Yip Y.L., Feng H.C., Cheung Y.C., Lo K.W., Meltzer P.S., Wu Z.G., Kwong Y.L., Yuen P.W. and Tsao S.W., Int J Cancer, Molecular and cytogenetic changes involved in the immortalization of nasopharyngeal epithelial cells by telomerase. 2006, 119: 1567-76. |
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Yuen
P.W., Endoscopic cranionasal resection of
anterior skull base cancer, First Indonesian Otorinolaryngology Head and
Neck Conference, |
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Yuen P.W. and Ng W.M., Laryngoscope, Surgical techniques and results of lateral thoracic cutaneous, myocutaneous, and conjoint flaps for head and neck reconstruction. 2007, 117: 288-94. |
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Yuen P.W., Lateral thoracic flap for head and neck reconstruction , First Indonesian Otorinolaryngology Head and Neck Conference, Jarkata, Indonesia, 2006 . 2006. |
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Yuen
P.W., Management tips of tongue cancer, First
Indonesian Otorinolaryngology Head and Neck Conference, |
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Yuen
P.W., Pathology and staging of neck -
problems and future directions, Crile centennial symposium, |
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Yuen
P.W., Plasma DNA markers of nasopharyngeal
carcinoma, First Indonesian Otorinolaryngology Head and Neck Conference, |
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Yuen P.W., Preservation of lateral thoracic artery to improve vascular supply of distal skin without compromising pedicle length in harvesting pectoralis major myocutaneous flap, Journal of Plastic Reconstructive & Aesthetic Surgery. 2006, 59: 1433-1435. |
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Yuen P.W. and Ng W.M., Surgical techniques and results of lateral thoracic cutaneous myocutaneous, and conjoint flaps for head and neck reconstruction, The Laryngoscope. 2007, 117: 288-294. |
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Yuen P.W., Cheung S.W.A.N.A., Tang K.C., Ho W.K., Wong B.Y.H., Cheung A.C.S. and Ho A.C.W., The skin prick test result of 977patients suffering from chronic rhinitis in Hong Kong, Hong Kong Medical Journal. 2007, 13: 131-136. |
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Yuen
P.W., Cheung S., Tang K.C., Ho W.K., Wong B.Y., Cheung A.C. and Ho
A.C., The skin prick test resutls of 977 patients suffering from chronic
rhinitis in Hong Kong, Hong Kong Medical Journal. |
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Researcher
: Yuen WK |
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List of Research Outputs |
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Chan A., Poon R.T.P., Mh K.C., Chan S.C., Yuen W.K., Yeung C., Lo C.M. and Fan S.T., Effect of changing paradigm for management of hepatocellular carcinoma on the long-term survival of patients with hepatocellular carcinoma (Abstract), The 1st Biennial Congress of the Asian-Pacific Hepato-Pancreato-Biliary Association, Fukuoka, Japan, 20 - 23 March 2007. |
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Chok K.S.H., Yuen W.K., Lau H. and Fan S.T., Prospective randomized trial on low-pressure versus standard-pressure pneumoperitoneum in outpatient laparoscopic cholecystectomy, Surgical Laparoscopy, Endoscopy and Percutaneous Techniques. 2006, 16(6): 383-386. |
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Lau H., Fang C., Yuen W.K. and Patil N.G., Risk factors for inguinal hernia in adult males: a case-control study, Surgery. 2007, 141(2): 262-266. |
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Leung
G.K.K., Ho Y.C.W. and Yuen W.K.,
The Effect of Inter-hospital Transfer on the Outcome of Trauma Patients , RSCEd/CSHK
Conjoint Scientific Congress, |
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Poon R.T.P., Fan S.T., Lo C.M., Ng K.K.C., Yuen W.K., Yeung C. and Wong J., External drainage of pancreatic duct with a stent to reduce leakage rate of pancreaticojejunostomy after pancreaticoduodenectomy: a prospective randomized trial (Abstract), Annual Meeting of American Surgical Association, Colorado Springs, USA, 26 - 28 April 2007. |
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Researcher
: Zhao Y |
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List of Research Outputs |
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Ng
T.P., Man K., Ho J.W.Y., Sun K.W., Lee K.W., Zhao Y., Lo C.M., Poon R.T.P. and Fan S.T., Marked suppression of tumor
growth by FTY |
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Yang Z., Ho D.W.Y., Ngai P.P., Lau C.K., Zhao Y., Poon R.T.P. and Fan S.T., Antiinflammatory properties of IL-10 rescue small-for-size liver grafts, Liver Transplantation. 2007, 13(4): 558-565. |
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Researcher
: Zhu R |
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List of Research Outputs |
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Lau G., Zhu R., Lei T., Ng M.Y., Luk J.M.C., Sham P., Chiu J.F. and He Q.Y., Identification of biomarkers for the prediction of HBV related HCC by integrated proteomics (Abstract), The 17th Asian Pacific Association for the Study of the Liver Conference, Kyoto, Japan, 27 - 30 March 2007. |
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Lau G., Zhu R., Lei T., Ng M.Y., Luk J.M.C., Sham P., Chiu J.F. and He Q.Y., Identification of biomarkers for the prediction of HBV related HCC by integrated proteomics, Hepatology International. 2007, 1(1): 75. |
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Researcher
: de Villa MVH |
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Project Title: |
Regeneration Pattern of Small-for-Size Fatty Liver Graft after Liver Transplantation in a Cirrhotic Recipient |
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Investigator(s): |
de Villa MVH, Man K, Wu EX |
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Department: |
Surgery |
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Source(s) of Funding: |
Seed Funding Programme for Basic Research |
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Start Date: |
03/2007 |
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Abstract: |
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Objectives of the study: 1. To characterize regeneration in small-for-size fatty liver grafts after transplantation in a cirrhotic recipient in terms of liver volumetry, cell proliferation index and gene expression profiles. 2. To identify hepatic progenitor cells or oval cells and determine their distribution within the liver at different time points in the early posttransplant period. 3. To compare the outcomes with those in non-fatty small-for-size liver grafts. Key issues and problems being addressed: The universal shortage of liver grafts for transplantation has led to the use of suboptimal or marginal grafts in terms of size and quality. Small-for size and/or fatty liver grafts have been used for liver transplantation with outcomes that are generally inferior compared to non-fatty grafts of adequate size. Injury is a stimulus to regeneration and regeneration patterns may vary according to type of injury. It has been shown that growth in the adult liver is a uniquely two-tiered with differentiated cells (hepatocytes) constituting the initial response to injury and progenitor cells (oval cells) functioning as a reserve compartment when hepatocyte proliferation fails. In the transplant setting involving small-for-size fatty liver grafts subjected to ischemia-reperfusion injury, the exact regenerative response is yet unknown. This study is, therefore, being undertaken to determine the regeneration patterns in terms of volume changes and cellular proliferation over time in a small-for-size fatty liver grafts transplanted in a cirrhotic recipient. This model mimics the clinical setting where live donor liver transplantation is resorted to because of the severe shortage of deceased donor grafts. The heightened interest in fatty liver grafts is brought about by the increasingly recognized high incidence of this pathologic entity in the general population, including potential liver donors. Often it becomes necessary to accept donors with some degree of fatty change in view of the urgency of the need for transplantation and the lack of alternative graft sources. It is, therefore, becoming increasingly important to better understand the behavior of fatty livers posttransplantation in order to optimize the use of this kind of graft without compromising both donor and recipient outcomes. In recent years there has been growing interest in the role of oval cells, also known as liver progenitor cells, in the regenerating liver due to their potential to differentiate into either hepatocytes or cholangiocytes. It would be worthwhile to further explore the mechanisms that push their differentiation into one type of cell or the other, specifically in the liver graft that may suffer some degree of bile duct injury. Moreover, the oval cell has likewise been linked to carcinogenensis and it has been suggested that this cell may actually be a precursor to hepatocellular carcinoma. It is then important to understand the factors that govern the behavior of these oval cells in the transplanted liver in order to maximize their regenerative potential while preventing the occurrence or progression of HCC. |
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List of Research Outputs |
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de Villa M.V.H., General principles of transplantation (Invited Lecture), Special Review Course for the FRCS Examination Candidates, Queen Mary Hospital, Hong Kong, 21 August 2006. 2006. |
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de Villa M.V.H., Liver transplantation for hepatocellular carcinoma: Asian perspective (Invited Lecture), Annual Scientific Meeting of the Hong Kong Society of Transplantation, Hong Kong, 1 April 2007. 2007. |
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de Villa M.V.H., Trustee and President (2004 - present), Liver Transplant Foundation, Inc. 2007. |
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