DENTAL FACULTY - CDC (ENDONDONTICS)



Researcher : Chang JWW

Project Title:Diagnostic and prognostic markers related to pathogenic bacteria in endodontic lesions of failed cases
Investigator(s):Chang JWW, Seneviratne CJ, Samaranayake LP, Cheung GSP
Department:Dental Faculty
Source(s) of Funding:Small Project Funding
Start Date:04/2011


List of Research Outputs

Chang J.W.W., Cheung A.W. and Cheung G.S.P., Effect of root canal dimensions, injection rate, and needle design on the apical extrusion of an irrigant: an in vitro study , Journal of Investigative and Clinical Dentistry. 2014, 6(3): 221-7.
Ekambaram M., Yiu C.K.Y., Matinlinna J.P., Chang J.W.W., Tay F.R. and King N.M., Effect of chlorhexidine and ethanol-wet bonding with a hydrophobic adhesive to intraradicular dentine, Journal of Dentistry. 2014, 42: 872-882.
Li D., Jiang S.M., Yin X., Chang J.W.W., Ke J. and Zhang C., Efficacy of Needle, Ultrasonic, and Endoactivator Irrigation and Photon-Induced Photoacoustic Streaming in Removing Calcium Hydroxide from the Main Canal and Isthmus: An In Vitro Micro-Computed Tomography and Scanning Electron Microscopy Study , Photomedicine and Laser Surgery. 2015, 33: 330-337.
Taschieri S., Fabbro M.D., Samaranayake L.P. and Chang J.W.W., Microbial Invasion Of Dentinal Tubules: A Literature Review And A New Perspective, Journal of Investigative and Clinical Dentistry. Wiley, 2014, 5: 163 - 170.


Researcher : Cheung GSP

Project Title:Stem cells in human dental pulp with irreversible pulpitis and their potential for tissue regeneration
Investigator(s):Cheung GSP, Zhang C, Chang JWW
Department:Dental Faculty
Source(s) of Funding:Small Project Funding
Start Date:03/2011


List of Research Outputs

Chang J.W.W., Cheung A.W. and Cheung G.S.P., Effect of root canal dimensions, injection rate, and needle design on the apical extrusion of an irrigant: an in vitro study , Journal of Investigative and Clinical Dentistry. 2014, 6(3): 221-7.
Cheung G.S.P., Seminar on "Nickel-titanium Instruments", UCL Eastman Dental Institute. 2015.
Ha J.H., Kim S.K., Cheung G.S.P., Jeong S.H., Bae Y.C. and Kim H.C., Effect of alloy type on the life-time of torsion-preloaded nickel-titanium endodontic instruments, Scanning. 2015, 37(3): 172-8.
Ha J.H., Kim S.R., Versluis A., Cheung G.S.P., Kim J.W. and Kim H.C., Elastic Limits in Torsion of Reciprocating Nickel-Titanium Instruments, Journal of Endodontics. 2015, 41(5): 715-9.
Kim J.W., Ha J.H., Cheung G.S.P., Versluis A., Kwak S.W. and Kim H.C., Safety of the Factory Preset Rotation Angle of Reciprocating Instruments, Journal of Endodontics. 2014, 40(10): 1671-5.
Mattheos N., Ho K.L. and Cheung G.S.P., Developing self assessment skills of dental students., South East Asia Association of Dental Education. 2014.
Mattheos N., Pow E.H.N., Ho K.L. and Cheung G.S.P., Development reflective skills of dental students through the teaching of implant dentistry, 25th South East Asia Association for Dental Education, Kuching, Malaysia. 2014.
WANG S., Liu K., Seneviratne C.J., Cheung G.S.P., Jin L. and Zhang C., Enterococcus faecalis LTA induces TNF-a through NF-kB and p38 pathways, Journal of Dental Research. 2014, 93 (Spec Iss C): IP_113 (SEA Division).
WANG S., Deng Z., Seneviratne C.J., Cheung G.S.P., Jin L. and Zhang C., Enterococcus faecalis promotes RANKL-dependent TRAP-positive osteoclastogenesis and semaphorin 4D expression, Journal of Dental Research. 2015, 94 (Spec Iss A): 2648.
Zhang C., WANG S., Deng Z., Seneviratne C.J., Cheung G.S.P. and Jin L., Enterococcus facaelis attenuates osteogenesis in MC3T3-E1 cells., Journal of Dental Research. 2015, 94 (Spec Iss A): 2655.


Researcher : Deng Z

List of Research Outputs

WANG S., Deng Z., Seneviratne C.J., Cheung G.S.P., Jin L. and Zhang C., Enterococcus faecalis promotes RANKL-dependent TRAP-positive osteoclastogenesis and semaphorin 4D expression, Journal of Dental Research. 2015, 94 (Spec Iss A): 2648.
Zhang C., WANG S., Deng Z., Seneviratne C.J., Cheung G.S.P. and Jin L., Enterococcus facaelis attenuates osteogenesis in MC3T3-E1 cells., Journal of Dental Research. 2015, 94 (Spec Iss A): 2655.


Researcher : Dissanayaka WL

Project Title:Characterization of single cell-derived clones of dental pulp stem cells
Investigator(s):Dissanayaka WL, Zhang C
Department:Dental Faculty - CDC (Endondontics)
Source(s) of Funding:Small Project Funding
Start Date:05/2015


Project Title:International Society for Stem Cell Research 2015 Annual Meeting ; EFFECTS OF CO-EXPRESSION OF C-MYC AND BCL-2 ON PROLIFERATION, APOPTOSIS AND SURVIVAL OF DENTAL PULP STEM CELLS
Investigator(s):Dissanayaka WL
Department:Dental Faculty - CDC (Endondontics)
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2015


List of Research Outputs

Dissanayaka W.L., ZHU L., Hargreaves K.M., Jin L. and Zhang C., In vitro analysis of scaffold-free prevascularized microtissue spheroids containing human dental pulp cells and endothelial cells, Journal of Endodontics. 2015, 41: 663-670.
Dissanayaka W.L., ZHU L., Hargreaves K.M., Jin L. and Zhang C., Scaffold-free prevascularized microtissue spheroids for pulp regeneration , Journal of Dental Research. 2014, 93(12): 1296-1303.
Dissanayaka W.L., Hargreaves K.M., Jin L., Samaranayake L.P. and Zhang C., The interplay of dental pulp stem cells and endothelial cells in an injectable peptide hydrogel on angiogenesis and pulp regeneration in vivo, Tissue Engineering Part A. 2015, 21(3-4): 550-563.
YUAN C., Wang P., ZHU L., Dissanayaka W.L., Green D.W., Tong E.H., Jin L. and Zhang C., Coculture of stem cells from apical papilla and human umbilical vein endothelial cell under hypoxia increases the formation of three-dimensional vessel-like structures in vitro, Tissue Engineering Part A. 2015, 21(5-6): 1163-1172.
ZHU L., Dissanayaka W.L., Green D.W. and Zhang C., Stimulation of EphB2/ephrin-B1 signalling by tumour necrosis factor alpha in human dental pulp stem cells, Cell Proliferation. 2015, 48: 231-238.


Researcher : Li D

List of Research Outputs

Li D., Jiang S.M., Yin X., Chang J.W.W., Ke J. and Zhang C., Efficacy of Needle, Ultrasonic, and Endoactivator Irrigation and Photon-Induced Photoacoustic Streaming in Removing Calcium Hydroxide from the Main Canal and Isthmus: An In Vitro Micro-Computed Tomography and Scanning Electron Microscopy Study , Photomedicine and Laser Surgery. 2015, 33: 330-337.


Researcher : Liu K

List of Research Outputs

WANG S., Liu K., Seneviratne C.J., Cheung G.S.P., Jin L. and Zhang C., Enterococcus faecalis LTA induces TNF-a through NF-kB and p38 pathways, Journal of Dental Research. 2014, 93 (Spec Iss C): IP_113 (SEA Division).


Researcher : YUAN C

List of Research Outputs

YUAN C., Wang P., ZHU L., Dissanayaka W.L., Green D.W., Tong E.H., Jin L. and Zhang C., Coculture of stem cells from apical papilla and human umbilical vein endothelial cell under hypoxia increases the formation of three-dimensional vessel-like structures in vitro, Tissue Engineering Part A. 2015, 21(5-6): 1163-1172.


Researcher : Yin X

List of Research Outputs

Li D., Jiang S.M., Yin X., Chang J.W.W., Ke J. and Zhang C., Efficacy of Needle, Ultrasonic, and Endoactivator Irrigation and Photon-Induced Photoacoustic Streaming in Removing Calcium Hydroxide from the Main Canal and Isthmus: An In Vitro Micro-Computed Tomography and Scanning Electron Microscopy Study , Photomedicine and Laser Surgery. 2015, 33: 330-337.


Researcher : ZOU T

List of Research Outputs

Jiang S., Huang X., Zhang C., Cai Z. and ZOU T., Morphological and proteomic analyses of the biofilms generated by streptococcus mutans isolated from caries-active and caries-free adults, Journal of Dental Sciences. 2015, 10(2): 206-215.


Researcher : Zhang C

Project Title:Prevascularized periodontal ligament cell sheet with endothelial cells promotes periodontal tissue complex regeneration
Investigator(s):Zhang C, Chu CH
Department:Dental Faculty - CDC (Endondontics)
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2012


Project Title:Bcl-2 and cMyc gene-transfected dental pulp stem cells outcompete bone marrow-derived cells in dental pulp regeneration
Investigator(s):Zhang C, Cheung GSP, Chang JWW
Department:Dental Faculty - CDC (Endondontics)
Source(s) of Funding:National Natural Science Foundation of China (NSFC) - General Program
Start Date:01/2013


Project Title:Engineering human dental pulp tissues using prevascularized microtissue spheroids constructed by dental pulp stem cells and gene-modified endothelial cells
Investigator(s):Zhang C, Cheung GSP, Jin L, Seneviratne CJ
Department:Dental Faculty
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2013


Project Title:Lipoteichoic acid (LTA) of pathogenic Enterococcus faecalis modulates the functional characteristics of osteoblasts and osteoclasts
Investigator(s):Zhang C, Seneviratne CJ, Jin L, Watt RM, Li XC
Department:Dental Faculty - CDC (Endondontics)
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:01/2013


Project Title:TNF-α Induction of Human Dental Pulp Stem Cells’ EphB2/ephrin-B1 Expression
Investigator(s):Zhang C
Department:Dental Faculty - CDC (Endondontics)
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2013


Project Title:Hypoxia enhances the angiogenic potential of stem cells from apical papilla via upregulation of VEGF and ephrinB2 expression
Investigator(s):Zhang C
Department:Dental Faculty - CDC (Endondontics)
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2014


Project Title:EphrinB2 and VEGF cooperatively regulate dental pulp stem cell functions and blood vessel formation
Investigator(s):Zhang C, Jin L, Cheung GSP
Department:Dental Faculty - CDC (Endondontics)
Source(s) of Funding:National Natural Science Foundation of China (NSFC) - General Program
Start Date:01/2015


Project Title:EphrinB2 enhances angiogenesis and anastomosis of bioengineered prevascularized dental pulp construct
Investigator(s):Zhang C, Cheung GSP, Jin L, Green DW
Department:Dental Faculty - CDC (Endondontics)
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2015


Project Title:93rd General Session and Exhibition of the International Association for Dental Research (IADR); Enterococcus faecalis Attenuates Osteogenesis in MC3T3-E1 Cells
Investigator(s):Zhang C
Department:Dental Faculty - CDC (Endondontics)
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:03/2015
Completion Date:03/2015


Project Title:Semaphorin 4D on angiogenesis and odontogenesis of human dental pulp stem cells
Investigator(s):Zhang C
Department:Dental Faculty - CDC (Endondontics)
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2015


List of Research Outputs

Chu C.H., Wong A.W.Y. and Zhang C., Post-operative pain of single versus multiple visit non-surgical endodontic therapy., IADR General Session. 2015.
Dissanayaka W.L., ZHU L., Hargreaves K.M., Jin L. and Zhang C., In vitro analysis of scaffold-free prevascularized microtissue spheroids containing human dental pulp cells and endothelial cells, Journal of Endodontics. 2015, 41: 663-670.
Dissanayaka W.L., ZHU L., Hargreaves K.M., Jin L. and Zhang C., Scaffold-free prevascularized microtissue spheroids for pulp regeneration , Journal of Dental Research. 2014, 93(12): 1296-1303.
Dissanayaka W.L., Hargreaves K.M., Jin L., Samaranayake L.P. and Zhang C., The interplay of dental pulp stem cells and endothelial cells in an injectable peptide hydrogel on angiogenesis and pulp regeneration in vivo, Tissue Engineering Part A. 2015, 21(3-4): 550-563.
Guo H., Gao C., Zhang C., Zheng S. and Yue L., Morphology of bacterial flora in root canals associated with apical abscesses, Chin Med J. 2014, 127(18): 3254-3258.
Jiang S., Huang X., Zhang C., Cai Z. and ZOU T., Morphological and proteomic analyses of the biofilms generated by streptococcus mutans isolated from caries-active and caries-free adults, Journal of Dental Sciences. 2015, 10(2): 206-215.
Keung C.W.Y., Wong A.W.Y., Zhang C. and Chu C.H., Perceptions of single-visit and multiple- visit endodontic treatment in Hong Kong., Journal of Dental Research. 2014, 94: IP-045.
LI M., Zhang C., Jin L., Matsuo K. and Yang Y., Influence of lipopolysaccharide on ephrin/eph expression in human periodontal ligament fibroblasts, The 91th Congress of the European Orthodontic Society, Venice, Italy, 13-18 June. 2015.
LI M., Zhang C., Jin L., Matsuo K. and Yang Y., Influence of lipopolysaccharide on ephrin/eph expression in human periodontal ligament fibroblasts, The 91th Congress of the European Orthodontic Society, Venice, Italy, 13-18 June, 2015.
LI M., Zhang C. and Yang Y., Oral presentation: Effects of LPS on Ephrin/Eph Signaling in PDL Fibroblasts, International Association for Dental Research South East Asia 28th Annual Scientific Meeting, Sarawak, Malaysia, 11-14 Aug 2014.
LIAO C., Zhang C., Jin L., Matsuo K. and Yang Y., Poster presentation: Expression of eph/ephrin signalling in osteocytes under mechanical loading, The 91th Congress of the European Orthodontic Society, Venice, Italy, 13-18 June, 2015.
Li D., Jiang S.M., Yin X., Chang J.W.W., Ke J. and Zhang C., Efficacy of Needle, Ultrasonic, and Endoactivator Irrigation and Photon-Induced Photoacoustic Streaming in Removing Calcium Hydroxide from the Main Canal and Isthmus: An In Vitro Micro-Computed Tomography and Scanning Electron Microscopy Study , Photomedicine and Laser Surgery. 2015, 33: 330-337.
Mei L., ITO L., Zhang C., Lo E.C.M. and Chu C.H., Effect of laser irradiation on the fluoride uptake of silver diamine fluoride treated dentine, Lasers in Medical Science. 2015, 30: 985-991.
Mei L., Ito L., Chu C.H., Lo E.C.M. and Zhang C., Prevention of dentine caries using silver diamine fluoride application followed by Er:YAG laser irradiation: an in vitro study, Lasers in Medical Science . 2014, 29: 1785-91.
WANG S., Liu K., Seneviratne C.J., Cheung G.S.P., Jin L. and Zhang C., Enterococcus faecalis LTA induces TNF-a through NF-kB and p38 pathways, Journal of Dental Research. 2014, 93 (Spec Iss C): IP_113 (SEA Division).
WANG S., Deng Z., Seneviratne C.J., Cheung G.S.P., Jin L. and Zhang C., Enterococcus faecalis promotes RANKL-dependent TRAP-positive osteoclastogenesis and semaphorin 4D expression, Journal of Dental Research. 2015, 94 (Spec Iss A): 2648.
YUAN C., Wang P., ZHU L., Dissanayaka W.L., Green D.W., Tong E.H., Jin L. and Zhang C., Coculture of stem cells from apical papilla and human umbilical vein endothelial cell under hypoxia increases the formation of three-dimensional vessel-like structures in vitro, Tissue Engineering Part A. 2015, 21(5-6): 1163-1172.
ZHU L., Dissanayaka W.L., Green D.W. and Zhang C., Stimulation of EphB2/ephrin-B1 signalling by tumour necrosis factor alpha in human dental pulp stem cells, Cell Proliferation. 2015, 48: 231-238.
Zhang C., 2014 Undergraduate exchange program, 4-8 August, Guanghua School of Stomatology, Sun Ya-sen University and Faculty of Dentistry, The Universitiy of Hong Kong. 2014.
Zhang C., A 4 hours lecture in Putonghua on pulp regeneration, Beijing, China 23 January, 2015.
Zhang C., A Keynote speech on Advances in Endodontics, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, China, 23 September, 2014.
Zhang C., A keynote speech on pulp regeneration, Guangxi Stomatological Association, Guangxi, China,10-12 December, 2014.
Zhang C., A keynote speech on pulp regeneration, West China School of Dentistry, Sichuan University, China, 4-6 December, 2014.
Zhang C., Prevention and dealing with pain after endodontic treatment, 17 October, 2014.
Zhang C., Problem-based Learning (PBL) at the HKU Faculty of Dentistry, Training program for a group of teachers from China Pharmaceutical University, 16 July. 2014.
Zhang C., Seminar of outstanding cases of micro-endodontic treatment, six clinical cases to exchange, Beijing, China, 9 June, Capital Medical University School of Stomatology . 2015.
Zhang C., Stem cell based regeneration and bone resorption, 2015 IADR/AADR/CADR General Session & Exhibition, Boston, USA, 11- 14 March. 2015.
Zhang C., Visit to the State Key Laboratory in oral diseases, West China School of Stomatology, Sichuan University, China, 11-13 June. 2015.
Zhang C., WANG S., Deng Z., Seneviratne C.J., Cheung G.S.P. and Jin L., Enterococcus facaelis attenuates osteogenesis in MC3T3-E1 cells., Journal of Dental Research. 2015, 94 (Spec Iss A): 2655.
Zhu X., Wang Y., LIU Y., Huang G.T.-.J. and Zhang C., Immunohistochemical and histochemical analysis of newly formed tissues in root canal space transplanted with dental pulp stem cells plus platelet-rich plasma, Journal of Endodontics. 2014, 40(10): 1573-1578.


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