DENTAL FACULTY

Researcher : Al KAAA

List of Research Outputs

 

Rabie A.B.M., Hagg E.U.O., Wong R.W.K. and Al K.A.A.A., Indian Hedgehog is a mechanotransduction mediator in mandibular condyles., Biological Mechanisms of Tooth Eruption, Resorption, and Movement - Proceedings of the Eighth International Conference, Phuket, Thailand, 2005. Eds. Davidovitch Z., Mah J. and Suthanarak S., University of South California, School of Dentistry . 2006, 179-189.

 

Researcher : Bendeus SAM

Project Title:

Correlation of the population size of mesenchymal cells and condylar growth

Investigator(s):

Bendeus SAM, Hagg EUO, Rabie ABM

Department:

Dental Faculty

Source(s) of Funding:

Seed Funding for New Staff

Start Date:

11/2003

 

Abstract:

To develop a scale to assess the number of mesenchymal stem cells and to measure the size of the condyles in children with retrognathic mandible, thereby identify the good candidates for functional appliance therapy.

 

Project Title:

Virtual or stone models of the dentition for diagnosis and assessment of treatment need

Investigator(s):

Bendeus SAM, McGrath CPJ, Hagg EUO

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

10/2005

 

Abstract:

The purposes of this studu are: 1) to compare assessment of orthodontic treatment need on plaster study models and virtual models 2) to compare assessment of space conditions of plaster models and virtual models

 

Project Title:

Antimicrobial Activity of Traditional Chinese Medicine (TCM) Against Candida Species

Investigator(s):

Bendeus SAM, Wong RWK, Samaranayake LP

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

01/2007

 

Abstract:

Introduction:Candida has arisen as a major human pathogen with the HIV/AIDS epidemic and the high prevalence of compromised populations due to increased transplantation and chemotherapeutic drug use (Ellepola and Samaranayake, 2000). Candidiasis has also emerged with high mortality rates, reported to be nearly 55% among compromised populations such as HIV/AIDS patients. Resurgence of candidiasis among this population has created a clinical dilemma due to emergence of non-albicans species such as C.glabrata, C.krusei and C.tropicalis as potential human pathogens. Further, the emergence of drug-resistant Candida in general and azoles in particular also contribute to drug failure in patients with oral candidiasis (White, Marr and Bowden, 1998). Thus, continuing efforts to develop new, more effective and safe antifungals against this ubiquitous pathogen are needed. "Traditional Medicines" in many parts of the world are essentially treatment modalities largely dependent on the properties of "medicinal plants". Although greater details of compounds isolated from these "traditional medicinal plants" are sparse in current literature, studies have shown that they have therapeutic properties of much interest. Moreover extracts of traditional medicinal plants have not only shown to be potentially therapeutic, but considerably less toxic (Masoko, Picard and Eloff, 2005). These properties make herbs, which are used in Traditional Chinese Medicine (TCM), good candidates as novel drugs. Hence, in this study, we attempt to evaluate eight TCM herbs for their anti-candidial activity. Thus, TCM herbs such as Cortex phellodendri Chinensis, Radix Scutellariae, Fructus Forsythiae, Rhizoma Coptidis, Radix bupleuri, Hebra Menthae, Flos Magnoliae, Flos Caryophylli will be assessed for their anti-fungal properties against six Candidia species namely C.ablicans, C.dubliensis, C.glabrata , C.krusei , C.tropicalis and C.parapsilosis. Objectives:1. To evaluate the anti-Candidial properties of TCM herbs namely Cortex phellodendri Chinensis, Radix Scutellariae, Fructus Forsythiae, Rhizoma Coptidis, Radix bupleuri, Hebra Menthae, Flos Magnoliae, Flos Caryophylli against six Candidia species 2. To determine the MIC values of potential anti-fungal agents3. To characterize the structural changes caused by TCM drugs on Candida cells.

 

List of Research Outputs

 

Bendeus S.A.M., Hagg E.U.O. and Wong R.W.K., Bracing for the future, Faculty Expressions 2006. 2006, 9.

 

Bendeus S.A.M., Song Y. and Rabie A.B.M., Microarray analysis of angiogenic genes in condylar cartilage, 82nd Congress of the European Orthodontic Society. 2006.

 

Bendeus S.A.M., Phan M. and Hagg E.U.O., Poster:Presentation: A comparison of changes of overjet and jaw- base relationship in treatment with removable and fixed functional appliance. , The Second Cross-Strait Four Regions Orthodontic Conference, Nanjing, China, 19 – 21 November, 2006. . 2006.

 

Bendeus S.A.M., Chua H.D.P. and Cheung L.K., The role of orthodontics in maxillary distraction of cleft patients., Transaction of 3rd Asia Pacific Congress on Craniofacial Distraction Osteogenesis. 2007, p. 177-8.

 

Cheung L.K., Chua H.D.P. and Bendeus S.A.M., Cleft Maxillary Distraction versus Orthognathic Surgery: Clinical Morbidities and Surgical Relapse , Plast Reconstr Surg . 2006, 118: 996-1008.

 

Cheung L.K., Chua H.D.P., Whitehill T.L., Ho M.Y., Bendeus S.A.M. and Samman N., Cleft distraction versus orthognathic surgery - which is more stable? , XVIII Congress of the European Association for Cranio-Maxillo facial Surgery, Barcelona, Spain. 2006.

 

Chua H.D.P., Bendeus S.A.M. and Cheung L.K., Distraction osteogenesis versus orthognathic surgery in CLP patients, Transaction of 3rd Asia Pacific Congress on Craniofacial Distraction Osteogenesis.. 2007, p.163-164.

 

Chua H.D.P., Bendeus S.A.M. and Cheung L.K., Long term stability of cleft distraction osteogenesis versus orthognathic surgery, 20th Annual Scientific Meeting, Faculty of Dentistry, The University of Hong Kong. 2006, p. 17.

 

Chua H.D.P., Bendeus S.A.M. and Cheung L.K., Long-term stability of ceft distraction osteogenesis versus orthognathic surgery (Winner of best oral presentation), Asian J Oral Maxillofac Surg. 2006, 18:3 (suppl 1): p. 34.

 

Chua H.D.P., Bendeus S.A.M. and Cheung L.K., Oral Presentation: Long-term Stability of Cleft Distraction Osteogenesis versus Orthognathic Surgery. , 20th Annual Scientific Meeting of the Faculty of Dentistry. 15th December, 2006; The Prince Philip Dental Hospital.. 2006, 17.

 

Edmad B.A.S.S.E.M., Sherif E.L.-.M.O.F.T.Y., Wong R.W.K., Bendeus S.A.M. and Rabie A.B.M., Vacular Endthelial Growth Factor Augments the Healing of Demineralized Bone Matrix Grafts, International Journal of Surgery. 2006, 4: 160-166.

 

Mok C.W., Zhou L., McGrath C.P.J., Hagg E.U.O. and Bendeus S.A.M., Agreement between study casts and their images in assessing of malocclusion and treatment need. , The Second Cross-Strait Four Regions Orthodontic Conference, Nanjing, China. 18-21 November, 2006.

 

Mok C.W., Zhou L., McGrath C.P.J., Hagg E.U.O. and Bendeus S.A.M., Poster Presentation: Agreement between study casts and their images in assessing of malocclusion and treatment need. , 20th Annual Scientific Meeting of the Faculty of Dentistry. 15th December, 2006; The Prince Philip Dental Hospital.. 2006.

 

Phan K.L.D., Bendeus S.A.M., Hagg E.U.O., Hansen K. and Rabie A.B.M., Comparison of the headgear activator and Herbst appliance - effects and post-treatment changes, European Journal of Orthodontics. 2006, 28 No.1: 594-604.

 

Wey M.C., Bendeus S.A.M., Peng L., Hagg E.U.O., Rabie A.B.M. and Robinson W., Stepwise advancement versus maximum jumping with headgear activator, European Journal of Orthodontics. 2007, 29: 283-293.

 

Zhou L., Mok C.W., Hagg E.U.O., McGrath C.P.J. and Bendeus S.A.M., Poster Presentation: Dentofacial characteristics among Hong Kong Chinese children in different occlusion catergories., The Second Cross-Strait Four Regions Orthodontic Conference, Nanjing, China. 18-21 November, 2006. . 2006.

 

Zhou L., Mok C.W., Hagg E.U.O., McGrath C.P.J. and Bendeus S.A.M., Poster Presentation: Sagittal dental arch relationship versus anteroposterior skeletal pattern among 12-years-old Hong Kong Chinese Children., 20th Annual Scientific Meeting of the Faculty of Dentistry. 15th December, 2006; The Prince Philip Dental Hospital.. 2006.

 

Researcher : Bendeus SM

Project Title:

Correlation of the population size of mesenchymal cells and condylar growth

Investigator(s):

Bendeus SAM, Hagg EUO, Rabie ABM

Department:

Dental Faculty

Source(s) of Funding:

Seed Funding for New Staff

Start Date:

11/2003

 

Abstract:

To develop a scale to assess the number of mesenchymal stem cells and to measure the size of the condyles in children with retrognathic mandible, thereby identify the good candidates for functional appliance therapy.

 

Project Title:

Virtual or stone models of the dentition for diagnosis and assessment of treatment need

Investigator(s):

Bendeus SAM, McGrath CPJ, Hagg EUO

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

10/2005

 

Abstract:

The purposes of this studu are: 1) to compare assessment of orthodontic treatment need on plaster study models and virtual models 2) to compare assessment of space conditions of plaster models and virtual models

 

Project Title:

Antimicrobial Activity of Traditional Chinese Medicine (TCM) Against Candida Species

Investigator(s):

Bendeus SAM, Wong RWK, Samaranayake LP

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

01/2007

 

Abstract:

Introduction:Candida has arisen as a major human pathogen with the HIV/AIDS epidemic and the high prevalence of compromised populations due to increased transplantation and chemotherapeutic drug use (Ellepola and Samaranayake, 2000). Candidiasis has also emerged with high mortality rates, reported to be nearly 55% among compromised populations such as HIV/AIDS patients. Resurgence of candidiasis among this population has created a clinical dilemma due to emergence of non-albicans species such as C.glabrata, C.krusei and C.tropicalis as potential human pathogens. Further, the emergence of drug-resistant Candida in general and azoles in particular also contribute to drug failure in patients with oral candidiasis (White, Marr and Bowden, 1998). Thus, continuing efforts to develop new, more effective and safe antifungals against this ubiquitous pathogen are needed. "Traditional Medicines" in many parts of the world are essentially treatment modalities largely dependent on the properties of "medicinal plants". Although greater details of compounds isolated from these "traditional medicinal plants" are sparse in current literature, studies have shown that they have therapeutic properties of much interest. Moreover extracts of traditional medicinal plants have not only shown to be potentially therapeutic, but considerably less toxic (Masoko, Picard and Eloff, 2005). These properties make herbs, which are used in Traditional Chinese Medicine (TCM), good candidates as novel drugs. Hence, in this study, we attempt to evaluate eight TCM herbs for their anti-candidial activity. Thus, TCM herbs such as Cortex phellodendri Chinensis, Radix Scutellariae, Fructus Forsythiae, Rhizoma Coptidis, Radix bupleuri, Hebra Menthae, Flos Magnoliae, Flos Caryophylli will be assessed for their anti-fungal properties against six Candidia species namely C.ablicans, C.dubliensis, C.glabrata , C.krusei , C.tropicalis and C.parapsilosis. Objectives:1. To evaluate the anti-Candidial properties of TCM herbs namely Cortex phellodendri Chinensis, Radix Scutellariae, Fructus Forsythiae, Rhizoma Coptidis, Radix bupleuri, Hebra Menthae, Flos Magnoliae, Flos Caryophylli against six Candidia species 2. To determine the MIC values of potential anti-fungal agents3. To characterize the structural changes caused by TCM drugs on Candida cells.

 

Researcher : Botelho MG

Project Title:

The effectiveness of professional and home bleaching in the treatment of tetracycline stained teeth

Investigator(s):

Botelho MG, Chan AWK

Department:

Dental Faculty

Source(s) of Funding:

Low Budget High Impact Programme

Start Date:

11/2000

 

Abstract:

To compare the clinical efficacy or professional chairside bleaching with self-administered home bleaching for the aesthetic management of tetracycline stained teeth; to determine the cost effectiveness of the two bleaching procedures.

 

Project Title:

Antimicrobial effect of antibacterial conditioners on bacterial biofilms associated with dental caries

Investigator(s):

Botelho MG

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2003

 

Abstract:

To determine the inhibitory effects of dental antibacterials and novel dental antibacterial tooth conditioners against bacteria in biofilms.

 

Project Title:

Reduction of bacterial adhesion using a novel flurocarbon coating

Investigator(s):

Botelho MG

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

09/2006

 

Abstract:

The objectives of the proposed study it to test a novel fluorocarbon coating applied using a novel application technique developed at the Hong Kong University of Science and Technology. In preliminary studies this nano-sized coating shows a reduced ability of single species of oral bacteria to adhere to the test surface. The aim of the study is to quantify this effect using dental pathogenic bacteria using a flow cell. It is aimed to test this coating on dental material used in prosthetic appliances. These surfaces in the oral environment have been shown to readily form dental biofilm growth that may contribute to dental caries or periodontal disease. The aim of the study is to analyze to what extent this nanolayer coating may have on preventing early biofilm formation.

 

Project Title:

The effect of Silver Diammine Fluoride on demineralized dentine in vitro

Investigator(s):

Botelho MG

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

10/2006

 

Abstract:

The aims of this project are:1 To investigate the effects of SDF on artificially de-mineralized dentin in vitro so as to determine its anticaries effect on treating active caries. This will involve an analysis of the effects of concentration and time of SDF on arresting caries as well as the variable of depth of the lesion. This will be investigated using micro-hardness testing, energy dispersive X-ray microanalysis (EDAX) and electron microprobe analysis (EPMA) 2 To investigate the potential effects of other caries arresting agents similar to SDF (eg Ag NO3, AgF, TiF6, SiF6, ZrF6, SnF6, GeF6, Sr F2, NaF, KI…) but that do not have the deleterious effects of blackening associated with Ag ions. 3 To investigate the effect of SDF on treated deminerlized dentine that is subjected to demineralization cycles and determine its resistance to acid attack.While various forms of fluoride have been shown to be effective in preventing dental caries, a relatively new form, Silver Diammine Fluoride (SDF) has shown potential in arresting existing enamel and dentine caries. The advantage of this agent is that it is clinically easy to apply, can be administrated by oral health care personal with minimal training and is cost effective. However, its main disadvantage is that the silver oxidizes and turns the tooth black. This would make it unacceptable by most adult patients in the general population if aesthetically visible

 

List of Research Outputs

 

Botelho M.G., Cast Adhesive Restorations in Dentistry, The Hong Kong Government Dental Service. 2007.

 

Botelho M.G., Resin bonded bridges, the current state of development. Management of localised tooth wear. , The Hong Kong Paedodontic Society. 2006.

 

Researcher : Chai JYC

List of Research Outputs

 

Chai J.Y.C., Chu F.C.S., Chow T.W., Shum N.C. and Hui W.W.H., Best Paper Award, Equal first 3 papers in International Journal of Prosthodontics in 2006, International Journal of Prosthodontics. 2007.

 

Researcher : Chan AWK

Project Title:

A study to investigate the attitude and effect of magnification on the clinical performance by dental undergraduates in the University of Hong Kong

Investigator(s):

Chan AWK, Cheung GSP

Department:

Dental Faculty

Source(s) of Funding:

Low Budget High Impact Programme

Start Date:

11/2000

 

Abstract:

To evaluate dental students' attitudes towards the use of magnification in dentistry; to investigate the effect of magnification on the quality of typical restorative procedures undertaken by dental students; to investigate the influence of the use of magnification on decision-making behaviour in restorative treatment planning.

 

List of Research Outputs

 

Chan A.W.K., Low D.C.Y., Cheung G.S.P. and Ng R.P.Y., A questionnaire survey of endodontic practice profile among dentists in Hong Kong, Hong Kong Dental Journal. 2006, 3: 80-87.

 

Chan A.W.K., Country Representative, 17th Annual Scientific Meeting of the Malaysian Endodontic Society. 2006.

 

Chan A.W.K., Country Representative, 2006 Kerr Roundtable. 2006.

 

Chan A.W.K., Presentation on "Micro endodontic", iMD Dental Symposium, Shanghai. 2006.

 

Researcher : Chan BY

List of Research Outputs

 

Chan B.Y., Dyson J.E. and Darvell B.W., Operator force vector measurement in clinical dental cutting procedures, 20th Annual Scientific Meeting, Faculty of Dentistry, The University of Hong Kong. 2006, 20: P21.

 

Researcher : Chau CM

List of Research Outputs

 

Chau C.M., Best poster presentation award, 20th Faculty Annual Scientific Meeting, Faculty of Dentistry, HKU. 2006.

 

Chau C.M., CT measurement of volumetric changes in bone graft in maxillary sinus, 16th International Congress of Dentomaxillofacial Radiology. 2007.

 

Researcher : Chen L

Project Title:

C-fos expression and chromosomal changes in human ameloblastoma

Investigator(s):

Chen L, Cheung LK, Wong MP

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

 

Abstract:

To study the overall pattern of chromosomal alteration in multicystic and unicystic ameloblastoma by CGH and identify the important regions which may harbor critical genes involved in ameloblastoma pathogenesis.

 

Researcher : Cheung BPK

List of Research Outputs

 

Samaranayake Y.H., Dassanayake R.S., Cheung B.P.K., Jayatilake J.A.M.S., Yeung S.K.W., Yau J.Y.Y. and Samaranayake L.P., Differential phospholipase gene expression by Candida albicans in artificial media and cultured human oral epithelium, APMIS. 2006, 114: 857-66.

 

Samaranayake Y.H., Samaranayake L.P., Cheung B.P.K., Parahitiyawa N.B., Yau J.Y.Y. and Yeung S.K.W., Inhibitory Effect of Lysozyme and antifungals against Candida albicans biofilms, Journal of Dental Research. New Orleans March 21-24, 85th General Session & Exhibition of the IADR, 2007, 86: Special Issue A.

 

Researcher : Cheung CS

List of Research Outputs

 

Wong A.H.H., Cheung C.S. and McGrath C.P.J., Developing a short form of Oral Health Impact Profile (OHIP) for dental aesthetics: OHIP-aesthetic, Community Dentistry and Oral Epidemiology. 2007, 35: 64-72.

 

Researcher : Cheung GSP

Project Title:

A diagnostic model for C-configuration in mandibular molars

Investigator(s):

Cheung GSP

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2002

 

Abstract:

To establish a diagnostic method according to the relationship between the radiographic features and the anatomy of the C-shaped canal system in the mandibular second molars by using the micro-computerized tomography (MicroCT); to evaluate the accuracy of such a diagnostic method in vivo.

 

Project Title:

Fracture of endodontic instruments

Investigator(s):

Cheung GSP, Darvell BW

Department:

Dental Faculty

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

04/2007

 

Abstract:

The use of nickel-titanium (NiTi) instruments has been shown to produce a better result in root canal preparation than conventional stainless-steel instruments as part of endodontic treatment (dental treatment, that is, for the shaping of the root canal of a tooth in readiness for filling and sealing). In the process, the instrument is subject to both torsional and bending fatigue which results in breakage at a frequency of concern to both dentists and patients because of the difficulties of retrieval of the remaining fragment. Such failures are poorly understood.Objective:The purpose of the proposed investigation is to identify the key factors relating to the initiation of failure of nickel-titanium (NiTi) root canal instruments in clinical use.Key issues and long-term impact:a) Breakage of NiTi instruments occurs during root canal treatment at a significant frequency.b) There is no warning of such fracture but little is known about the underlying conditions and mechanism.c) Understanding the mechanism of failure and improving the material properties should lead to a reduction or elimination of such procedural errors in clinical practice.Problems to be addressed:(i) Identifying the mode and mechanism of fracture of NiTi instruments in use;(ii) Correlation of such failures with laboratory-generated fractures;(iii) Identifying the site of crack initiation;(iv) Identifying factors that predispose the instrument to failure.

 

List of Research Outputs

 

Chan A.W.K., Low D.C.Y., Cheung G.S.P. and Ng R.P.Y., A questionnaire survey of endodontic practice profile among dentists in Hong Kong, Hong Kong Dental Journal. 2006, 3: 80-87.

 

Cheng Y., Cheung G.S.P., Bian Z. and Peng B., Incidence and factors associated with endodontic inter-appointment emergency in a dental teaching hospital in China, Journal of Dentistry. 2006, 34: 516-521.

 

Cheung G.S.P., "Communications between the pulp and periodontium, and their clinical implications" and "Precautions for NiTi engine-files, and rationales and technique for using NiTi instruments by hand", 14th Oman Dental Conference, Muscat, Sultanate of Oman. 2006.

 

Cheung G.S.P. and Darvell B.W., "Low-cycle fatigue of Ni-Ti rotary instrument", 14th Asian Pacific Endodontic Confederation Scientfic Session (April '07), Jakarta, Indonesia. 2007.

 

Cheung G.S.P., "Predicting the fatigue life of NiTi instruments in use", 5th Joint Meeting of the Malaysian Endodontic Society and the Society of Endodontists of Singapore, Kuala Lumpur, Malaysia. 2006.

 

Cheung G.S.P., Bian Z., Shen Y., Peng B. and Darvell B.W., Comparison of defects in ProTaper hand-operated and engine-driven instruments after clinical use, International Endodontic Journal. 2007, 40: 169-178.

 

Cheung G.S.P., Editorial Board of ENDO - Endodontic Practice Today. 2007.

 

Cheung G.S.P., Endodontics, Joint HKU/Eastman Dental Institute CE Course at Peking University, Beijing, PRC. 2006.

 

Cheung G.S.P., Hong Kong Dental Journal. 2006.

 

Cheung G.S.P., Yang J. and Fan B., Morphometric study of the apical anatomy of C-shaped root canal systems in mandibular second molars, International Endodontic Journal. 2007, 40: 239-246.

 

Cheung G.S.P., PhD Thesis: Endodontic instruments, 2006.

 

Cheung G.S.P. and Darvell B.W., Predicting the fatigue life of NiTi instruments in use, Endodontic Bulletin. 2006, 17: 17-23.

 

Cheung G.S.P., Roots: the international magazine of Endodontics. 2007.

 

Cheung G.S.P., Visiting Associate Professor of Guanghua College of Stomatology at Sun Yat-sen University for the period from January, 2007 to December, 2009, 2007.

 

Cheung L.H.M., Low D.C.Y. and Cheung G.S.P., Root morphology - A study of the mandibular second molar of ethnic Chinese, Ann Roy Australas Coll Dent Surg. 2006, 18: 47-50.

 

Gao Y., Fan B., Cheung G.S.P., Gutmann J.L. and Fan M.W., C-shaped canal system in mandibular second molars Part IV: 3-D morphological analysis and transverse measurement, Journal of Endodontics. 2006, 32: 1062-1065.

 

Liu S.B., Fan B., Cheung G.S.P., Pang B., Fan M.W., Gutmann J.L., Song Y.L., Fu Q. and Bian Z., Cleaning effectiveness and shaping ability of rotary ProTaper compared with rotary GT and manual K-Flexofile, American Journal of Dentistry. 2006, 19: 353-358.

 

Min Y., Fan B., Cheung G.S.P., Gutmann J.L. and Fan M.W., C-shaped canal system in mandibular second molars Part III: The morphology of the pulp chamber floor, Journal of Endodontics. 2006, 32: 1155-1159.

 

Shen Y., Bian Z., Cheung G.S.P. and Peng B., Analysis of defects in ProTaper hand-operated instruments after clinical use, Journal of Endodontics. 2007, 33(3): 287-290.

 

Wei X. and Cheung G.S.P., (Application of the operating microscope in clinical endodontics), 第十八章: 手術顯微鏡在牙髓病學中的應用, (Modern Root Canal Therapy; Chapter 18). In: 王曉儀, 朱亞琴 (ed.) 現代根管治療學, 人民衛生出版社, 2006, 179-215.

 

Researcher : Cheung LHM

List of Research Outputs

 

Cheung L.H.M., Low D.C.Y. and Cheung G.S.P., Root morphology - A study of the mandibular second molar of ethnic Chinese, Ann Roy Australas Coll Dent Surg. 2006, 18: 47-50.

 

Researcher : Cheung LK

Project Title:

Cell cultured mucosal compound graft healing - an animal study

Investigator(s):

Cheung LK, Tipoe GL

Department:

Dental Faculty

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

07/1999

 

Abstract:

To establish an animal model for the studying of healing cell cultured compound graft in the oral environment; to study the histological healing process of cell cultured mucosal transplant on the palate; to analyse the phenotypic characteristic of the healed graft before and after healing.

 

Project Title:

Transport distraction in the treatment of temporomandibular joint ankylosis

Investigator(s):

Cheung LK, Shi X

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2003

 

Abstract:

To establish an animal model of temporomandibular joint ankylosis; to compare the healing between condylectomy and transport distraction of the posterior mandibular ramus in the treatment of temporomandibular joint ankylosis.

 

Project Title:

Biochemical modulation of distraction of osteogenesis in mandibular lengthening

Investigator(s):

Cheung LK, Zheng L

Department:

Dental Faculty

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

12/2003

 

Abstract:

To determine the effect of rhBMP-2 on bone regeneration in mandibular distraction osteogenesis under different distraction rates; to determine the effect of recombinant tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) on the bone resorption in mandibular distraction osteogenesis; to study the expression of endogenous BMPs, vacular endothelial growth factor (VEGF), matrix metalloproteinases (MMPs) and TIMPs at different distraction time; to compare the expression of endogenous BMPs, VEGF, MMPs and TIMPs under the influence of continuous or intermittent distraction.

 

Project Title:

Injectable tissue-engineered bone for mandibular distraction osteogenesis in smokers

Investigator(s):

Cheung LK, Zheng L

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

12/2005

 

Abstract:

The objectives of the present study are:1. To establish a nicotine-induced compromised bone healing (NICBH) model of rabbit mandibular distraction osteogenesis.2. To compare the differentiation and proliferation of mesenchymal stem cells (MSCs) isolated from normal and "smoking" rabbits.3. To study the influence of platelet rich plasma (PRP) on MSCs isolated from normal and "smoking" rabbits.4. To compare the influence of PRP, MSCs/PRP, and MSCs/PRP/bone morphogenetic protein (BMP) on enhancing bone healing in mandibular distraction osteogenesis of "smoking" rabbits.It is well recognized that nicotine has a deleterious effect on the human health in many aspects, one of them is that it can impact adversely on the tissue healing process after trauma and surgery. Thus the patients, who use tobacco products commonly as smoking, will be at a greater risk from bone reconstruction surgery. This study attempts to establish a reliable and repeatable NICBH model in rabbit undergoing mandibular distraction, which simulates the in vivo biological situation of light and heavy smokers having the same surgery.The individual MSCs, PRP and BMP have been identified to be capable of enhancing bone formation in mandibular reconstruction, it is reasonable to assume that they may speed up bone healing in the NICBH model. This study attempt to explore the potential of using PRP, MSCs and recombinant human BMP-2 (rhBMP-2) togather to enhance bone regeneration, and find a effective method to meet the clinical challenge of smokers who need bone reconstructive surgery by distraction osteogenesis.

 

Project Title:

Modulation of distraction osteogenesis in the irradiated mandible

Investigator(s):

Cheung LK, Zheng L, Chua DTT

Department:

Dental Faculty

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

01/2007

 

Abstract:

Purpose: To use an animal model to examine the role of genetically modified mesenchymal stem cells (MSCs) expressing bone morphogenetic protein-2 in improving a clinical tissue-engineering method (distraction osteogenesis) for jawbone reconstruction in irradiated mandible. Key issues and problems:1) High-dose irradiation used in the treatment of oral cancer compromises the biological environment of bone significantly, and results in decreased blood flow and progressive fibrosis. Mandibular bone is especially prone to irradiation damage because of its limited vascular supply and compact bony structure. 2) Conventional bone reconstructive surgery uses bone grafting, itself associated with wound complications at the donor graft site, but distraction osteogenesis regenerates bone without a graft by the gradual separation of the divided bone segments using a mechanical device. This method could be further improved for irradiated bone with stem cell technology.3) Distraction osteogenesis provides a promising tool to reconstruct the continuity defects of previously irradiated mandibles, but the compromised wound healing ability following radiotherapy, such as decreased vascularity and cellularity, hinders its application and remains the major concerns of the surgeons. 4) Implantation of pluripotent MSCs enhances bone healing and regeneration in wound-healing models. It is unknown whether transplanted MSCs retain their proliferation and differentiation abilities and reverse the compromised environment.5) Addition of growth factors may help MSCs in bone healing:i) Platelet-rich plasma (PRP) contains many growth factors in a biologically determined ratio and enhances the revascularization of wounds following trauma or surgery. However, its influence on distraction osteogenesis in an irradiation-compromised environment is unknown.ii) Bone morphogenetic protein-2 (BMP-2) is one of the most important protein that aid bone formation and healing. It is reasonable to expect but has not been studied that genetically modified MSCs expressing BMP-2 to compensate for low vascularity and cellularity caused by irradiation.Main study hypothesis: Genetically modified MSCs expressing BMP-2 in combination with PRP can reverse decreased vascularity and cellularity, thereby enhancing bone healing during jaw distraction osteogenesis in rabbits with irradiation compromised healing ability.Study objectives:1) To study the influence of radiation on a rabbit model of mandibular distraction osteogenesis.2) To explore the role of genetically modified MSCs in combination with PRP, in bone healing during jaw distraction osteogenesis in irradiation-compromised rabbits.

 

List of Research Outputs

 

Bendeus S.A.M., Chua H.D.P. and Cheung L.K., The role of orthodontics in maxillary distraction of cleft patients., Transaction of 3rd Asia Pacific Congress on Craniofacial Distraction Osteogenesis. 2007, p. 177-8.

 

Chanchareonsook N., Whitehill T.L., Samman N. and Cheung L.K., Speech outcome and velopharyngeal function in Cantonese cleft patients: comparison of Le Fort I maxillary osteotomy and distraction osteogenesis - a pilot study, Asian J Oral Maxillofac Surg. 2006, 18, no. 3 (suppl 1): p. 30-31.

 

Cheung L.K., Advances in dental implant surgical navigation and stereomodel technology, 2006 Annual Congress of the The Academy of Oral Implantology. 2006, p. 9.

 

Cheung L.K., Advances on dental surgical navigation and stereomodel technology (invited lecture), 2006 Annual Congress of the Academy of Oral Implantology, Taipie, Taiwan. 2006.

 

Cheung L.K., Art and science of orthognathic surgery. Distraction osteogenesis of the maxillofacial skeleton - experience from Hong Kong (keynote), School of Dental Sciences, Universiti Sains Malaysia. 2006.

 

Cheung L.K., Associate Editor since April 1999, International Journal of Oral and Maxillofacial Surgery. 2006.

 

Cheung L.K., Associate Editor-in-Chief since 1996, Chinese Journal of Oral Implantology. 2006.

 

Cheung L.K., Bimaxillary Distraction in Hemifacial Microsomia: a Clinical and Radiographic Analysis of 6 Patients?, 18th Congress of the European Association for Cranio-maxillofacial Surgery EACMFS Barcelona 2006, Barcelona, Spain. 2006.

 

Cheung L.K., Biochemical modulation of distraction osteogenesis by growth factors in jaw lengthening (invited lecture), 4th Tissue Engineering Symposium, Tampere, Finland. 2007.

 

Cheung L.K. and Zheng L., Biochemical modulation of distraction osteogenesis by growth factors in jaw lengthening, 4th Tissue Engineering Symposium. 2007, p. 3.

 

Cheung L.K., Biological basis for maxillofacial bone reconstruction. Behavior of bone grafts, bone substitutes and growth factors. Advances in stereomodel fabrication. Vascularized flaps in maxilofacial reconstruction. Development and choices of maxillofacial distractors., 2nd Annual Asian Hospital and Medical Center Symposium on Oral and Maxillofacial Surgery, Alabang, Philippines. 2007.

 

Cheung L.K., Changing faces by distraction osteogenesis (invited lecture), The Royal College of Surgeons of Edinburgh / The Royal College of Surgeons of Hong Kong Conjoint Scientific Congress "Surgery: East Meet West", Hong Kong Academy of Medicine, Hong Kong. 2006.

 

Cheung L.K., Changing faces by distraction osteogenesis - a clinical tissue engineering method (invited lecture), Research Symposium, Finnish Dental Society Apollonia, Tampere, Finland. 2007.

 

Cheung L.K., Chua H.D.P. and Bendeus S.A.M., Cleft Maxillary Distraction versus Orthognathic Surgery: Clinical Morbidities and Surgical Relapse , Plast Reconstr Surg . 2006, 118: 996-1008.

 

Cheung L.K., Cleft Maxillary Distraction with video surgical demonstration (Chairman), 3rd Asia Pacific Congress on Craniofacial Surgery & Distraction Oteogenesis, Bandos Convention Centre, Republic of Maldvies. 2007.

 

Cheung L.K., Cleft distraction versus orthognathbic surgery - which is more stable?, 8th Congress of European Association of Craniomaxillofacial Surgeons, Barcelona, Spain. 2006.

 

Cheung L.K., Chua H.D.P., Whitehill T.L., Ho M.Y., Bendeus S.A.M. and Samman N., Cleft distraction versus orthognathic surgery - which is more stable? , XVIII Congress of the European Association for Cranio-Maxillo facial Surgery, Barcelona, Spain. 2006.

 

Cheung L.K., Cleft distraction versus orthognathic surgery - which is more stable?, Journal of Cranio-Maxillofacial Surgery. 2006, 34 (Suppl. S1): p. 98.

 

Cheung L.K., Clinical facial assessment, Cephalometric analysis. Resorbable fixation for orthognathic surgery. Class III deformity, Long face syndrome, Prediction tracing. Craniofacial syndrome, nasomaxillary hypoplasia (Chairman, Keynote lectures), Orthognathic surgery course, Manila, Philippines. 2007.

 

Cheung L.K., Distraction of the Cleft Maxilla (invited lecture), 7th Asian Congress of Oral and Maxillofacial Surgery, Hong Kong Convention and Exhibition Centre, Hong Kong, SAR China. 2006.

 

Cheung L.K., Distraction of the cleft maxilla, Asian Journal of Oral and Maxillofacial Surgery. 2006, 18:3 (Suppl 1): p. 10.

 

Cheung L.K., Distraction osteogenesis for the maxillofacial region - experience from Hong Kong (keynote lecture), Functional Reconstruction of the Maxillofacial Region, Department of Oral and Maxillofacial Surgery, University of Napoli, Napoli, Italy. 2007.

 

Cheung L.K., Editor (2001-2007), Hong Kong Medical Journal. 2006.

 

Cheung L.K., Editor since 1996, Stomatology Progress. 2006.

 

Cheung L.K., Editor since 1997, Chinese Journal of Oral and Maxillofacial Surgery. 2006.

 

Cheung L.K., Editor since 2000, Asian Journal of Oral and Maxilofacial Surgery. 2006.

 

Cheung L.K., Editor since 2001, Chinese Journal of Stomatological Information. 2006.

 

Cheung L.K., Editor since 2002, West China Journal of Stomatology. 2006.

 

Cheung L.K., Editor since 2002, Year-Book of Chinese Stomatology. 2006.

 

Cheung L.K., Zheng L. and Ma L., Effect of distraction rates on expression of bone morphogenetic proteins in rabbit mandibular distraction osteogenesis, Journal of Cranio-maxillofacial Surgery. 2006, 34: 263-9.

 

Cheung L.K., Endoscopic assisted rigid fixation in intra-oral vertical subsigmoid osteotomy, 18th Congress of the European Association for Cranio-maxillofacial Surgery EACMFS Barcelona 2006, Barcelona, Spain. 2006.

 

Cheung L.K., Functional Reconstruction with Dental Implants (invited lecture), AO Symposium on Advanced Fixation for Cranio-maxillofacial Trauma and Reconstruction. 7th Asian Congress of Oral and Maxillofacial Surgery. Hong Kong Convention and Exhibition Centre. 2006.

 

Cheung L.K., Functional reconstruction of the mandible following oncological resection (invited lecture), The Macau Society of Haematology and Oncology. 2006.

 

Cheung L.K., Functional reconstruction with dental implants, Proceedings of AO Symposium on Advanced Fixation for Cranio-maxillofacial Trauma and Reconstruction. 2006, p. 101-104.

 

Cheung L.K., Honorary Editorial Advisor since 2003, Hong Kong Dental Journal. 2006.

 

Cheung L.K., Invited International Editorial Board Member since 2002, China Journal of Oral and Maxillofacial Surgery. 2006.

 

Cheung L.K., Management of facial asymmetry, Orthognathic Surgery Symposium Manila, Philippines. 2007.

 

Cheung L.K. and Chua H.D.P., Maxillary distraction for patients with cleft lip and palate, In: William H. Bell, César A. Guerrero, Distraction Osteogenesis of the Facial Skeleton. BC Decker Inc, Hamilton, 2007, p. 529-542.

 

Cheung L.K., Loh J.S.P. and Ho M.Y., Psychological profile of Chinese with cleft lip and palate deformities, Cleft Palate-Craniofacial Journal. 2007, 44: 79-86.

 

Cheung L.K., Reconstruction of the jaws with micro-vascular flaps. Advances in Clinical Dental Implantology (keynote lecture), 1st Annual Asian Hospital and Medical Center Symposium on Oral and Maxillofacial Surgery, Alabang, Philippines. 2006.

 

Cheung L.K., Reviewer since March 2006, Journal of Biomechanics. 2006.

 

Cheung L.K., Special Invited Editor since 2003, Chinese Journal of Craniomaxillofacial Surgery. 2006.

 

Cheung L.K., Special Invited Editor since 2003, Chinese Journal of Stomatological Research. 2006.

 

Cheung L.K., Shi X. and Zheng L., Surgical induction of temporomandibular joint ankylosis: an animal model, Journal of Oral and Maxillofacial Surgery. 2007, 65: p. 993-1004.

 

Cheung L.K., Loh J.S.P. and Ho M.Y., The early psychological adjustment of cleft patients after maxillary distraction osteogenesis and conventional orthognathic surgery: A preliminary study, Journal of Oral and Maxillofacial Surgery. 2006, 64: 1743-1750.

 

Cheung L.K. and Lo J., The long-term effect of transport distraction in the management of temporomandibular joint ankylosis, Plast Reconstr Surg. 2007, 119(3): 1003-9.

 

Cheung L.K., Tissue engineering for mandibular bone lengthening in smokers (invited lecture), International Biotechnology Symposium on "From Basic Research to Clinical Applications using Biotechnology and Bioengineering", University Hospital Lausanne, Lausanne, Switzerland. 2006.

 

Cheung L.K., Ma L. and Zheng L., Tissue engineering for mandibular bone lengthening in smokers. , Europen Cell and Materials . 2007, 13: 9.

 

Cheung L.K., Ma L. and Zheng L., Tissue engineering for mandibular bone lengthening in smokers, International Biotechnology Symposium on "From Basic Research to Clinical Applications using Biotechnology and Bioengineering". 2006, p.36.

 

Cheung L.K., Updates on the management of impacted third molars (invited lecture), Oral Health and Science Seminar. The Faculty of Dentistry, The University of Hong Kong. 2006.

 

Cheung L.K., Use or resorbable fixation for orthognathic surgery - experience from Hong Kong (invited lecture), 7th Asian Congress of Oral and Maxillofacial Surgery. Hong Kong Convention and Exhibition Centre. 2006.

 

Chua H.D.P., Whitehill T.L., Samman N. and Cheung L.K., Cleft distraction versus orthognathic surgery - which one cause less disturbance on resonance?, J Cranio-maxillofac Surg. 2006, 34 (suppl. S1): p. 37.

 

Chua H.D.P., Ho M.Y. and Cheung L.K., Cleft distraction versus orthognathic surgery - which one causes more distress?, J Cranio-maxillofac Surg. 2006, 34 (suppl. S1): p. 12.

 

Chua H.D.P. and Cheung L.K., Distraction osteogenesis for the cranio-maxillofacial region (I): a compendium of devices for the maxilla and midface, Asian J Oral Maxillofac Surg. 2006, 18: 248-58.

 

Chua H.D.P., Bendeus S.A.M. and Cheung L.K., Distraction osteogenesis versus orthognathic surgery in CLP patients, Transaction of 3rd Asia Pacific Congress on Craniofacial Distraction Osteogenesis.. 2007, p.163-164.

 

Chua H.D.P., Bendeus S.A.M. and Cheung L.K., Long term stability of cleft distraction osteogenesis versus orthognathic surgery, 20th Annual Scientific Meeting, Faculty of Dentistry, The University of Hong Kong. 2006, p. 17.

 

Chua H.D.P., Bendeus S.A.M. and Cheung L.K., Long-term stability of ceft distraction osteogenesis versus orthognathic surgery (Winner of best oral presentation), Asian J Oral Maxillofac Surg. 2006, 18:3 (suppl 1): p. 34.

 

Chua H.D.P., Bendeus S.A.M. and Cheung L.K., Oral Presentation: Long-term Stability of Cleft Distraction Osteogenesis versus Orthognathic Surgery. , 20th Annual Scientific Meeting of the Faculty of Dentistry. 15th December, 2006; The Prince Philip Dental Hospital.. 2006, 17.

 

Gunaseelan R., Cheung L.K., Krishnaswamy R. and Veerabahu M., Anterior maxillary distraction by tooth-borne palatal distractor, Journal of Oral and Maxillofacial Surgery. 2007, 65: p. 1044-1049.

 

Lo J. and Cheung L.K., Bimaxillary distraction in hemifacial microsomia: a retrospective study of 6 patients, Abstract of XVIII Congress of the European Association for Cranio-Maxillofacial Surgery, 12 - 15 September. 2006, Abstract No. 0-262.

 

Lo J. and Cheung L.K., Bimaxillary distraction in hemifacial microsomia: a retrospective study of 6 patients, Journal of Cranio-Maxillofacial Surgery. 2006, 34 (Suppl. S1): p. 99.

 

Lo J. and Cheung L.K., Craniofacial Fibrous Dysplasia, Asia Hospital & Center Annual Symposium on Oral & Maxillofacial Surgery, Manila, Plippines. 2007.

 

Lo J. and Cheung L.K., Distraction Osteogenesis for the craniomaxillofacial region. Part 2: a compendium of devices for the mandible, Asian J Oral Maxillofac Surg. 2007, 19: p. 6-18.

 

Lo J. and Cheung L.K., Endoscopic assisted rigid fixation in intra-oral vertical subsigmoid osteotomy: a preliminary study, Abstracts of XVIII Congress of the European Association for Journal of Cranio-Maxillofacial Surgery. 2006, 34 Suppl. S1: p.77 Abstract No 0.276.

 

Lo J. and Cheung L.K., Endoscopic-assisted rigid fixation in intra-oral vertical subsigmoid osteotomy: a preliminary clinical study, Surgical Practice . 2006, 10 (Suppl): p. A6.

 

Lo J. and Cheung L.K., Endoscopic-assisted rigid fixation of condylar fracture: a technical note, Journal of Oral and Maxillofacial Surgery. 2006, 64: 1443-1446.

 

Lo J. and Cheung L.K., Management of facial asymmetry, 2007 Orthognathic Surgery Symposium, Manila, Philippines . 2007.

 

Ma L. and Cheung L.K., Effect of nicotine on bone healing in mandibular distraction osteogenesis, 20th Annual Scientific Meeting, Faculty of Dentistry, The University of hong Kong. 2006, p. 23.

 

Ma L. and Cheung L.K., Effect of nicotine on bone healing in mandibular distraction osteogenesis, Asian J Oral Maxillofac Surg. 2006, 18:3 (suppl 1): p. 47.

 

Ma L., Zheng L. and Cheung L.K., Effect of nicotine on bone regeneration in mandibular distractin osteogenesis, Transactions of 3rd Asia Pacific Congress on Craniofacial Surgery & Distraction Osteogenesis. 2007, p. 259-271.

 

Ma L., Zheng L. and Cheung L.K., Inhibitory effect of nicotine on bone regeneration in mandibular distraction osteogenesis, Frontiers in Bioscience. 2007, 12: 3256-62.

 

Ow A. and Cheung L.K., Bilateral sagittal split osteotomies (BSSO) and mandibular distraction osteogenesis (MDO) for mandibular advancement: which is more stable?, 20th Annual Scientific Meeting, Faculty of Dentistry, The University of Hong Kong. 2006, p.17.

 

Ow T.C.A. and Cheung L.K., Bilateral sagittal split osteotomies and mandibular distraction osteogenesis: a meta-analysis on their stability and morbidities, Asian J Oral Maxillofac Surg. 2006, 18:3 (suppl 1): p. 49.

 

Yeung R.W.K., Samman N., Cheung L.K., Zhang C...P... and Chow R.L.K., Stereomodel-assisted fibula flap harvest and mandibular reconstruction, Journal of Oral and Maxillofacial Surgery. 2007, 65: p.1128-1134.

 

Yip H.S., Cheung L.K. and Chow R.L.K., Stability and morbidities of Le Fort I osteotomies with bioresorbable fixation - a randomized controlled trial, Asian J Oral Maxillofac Surg. 2006, 18:3 (Suppl 1): p. 61.

 

Yip I.H.S., Cheung L.K. and Chow R.L.K., Stability and morbidities of Le Fort I osteotomies with bioresorbable fixation - a randomized controlled trial, 20th Annual Scientific Meeting, Faculty od Dentistry, The University of Hong Kong. 2006, p.16.

 

Yip I.H.S., Cheung L.K. and Chow R.L.K., Stability and morbidities of Le Fort I osteotomies with bioresorbable fixation - a randomized controlled trial, Journal of Cranio-Maxillofacial Surgery. 2006, 34 (Suppl. S1): p. 115.

 

Zheng L. and Cheung L.K., Biochemical and mechanical modulation of distraction osteogenesis (Winner of Dean's award for the Best Oral Presentation - Senior Category), 20th Annual Scientific Meeting, Faculty of Dentistry, The University of Hong Kong. 2006, p. 22.

 

Zheng L., Ma L. and Cheung L.K., Effect of nicotine on expression of bone morphogenetic protein-2 in rabbit mandibular distraction osteogenesis, 4th Tissue Engineering Symposium. 2007, p. 64.

 

Zheng L., Ma L. and Cheung L.K., Effect of nicotine on mandibular distraction osteogenesis: a radiological and immunohistochemical study, Europen Cell and Materials. 2007, 13: 54.

 

Zheng L., Ma L. and Cheung L.K., Effect of nicotine on mandibular distraction osteogenesis: a radiological and immunohistochemical study, International Biotechnology Symposium on "From Basic Research to Clinical Applications using Biotechnology and Bioengineering". 2006, Poster 04.

 

Zheng L. and Cheung L.K., Effect of recombinant human bone morphogenetic protein-2 on mandibular distraction at different rates in a rabbit model, Asian J Oral Maxillofac Surg. 2006, 18:3 (Suppl 1): p.63.

 

Zheng L. and Cheung L.K., Effect of recombinant human bone morphogenetic protein-2 on mandibular distraction at different rates in a rabbit model, Tissue Engineering. 2006, 12: 3181-3188.

 

Zheng L. and Cheung L.K., Effect of recombinant human tissue inhibitor of matrix metalloproteinase-1 in rabbit mandibular distraction osteogenesis, 4th Tissue Engineering Symposium. 2007, p. 23.

 

Zheng L., Ma L. and Cheung L.K., Effect of recombinant human tissue inhibitor of matrix metalloproteinase-1 in rabbit mandibular distraction osteogenesis: a histological and immunohistochemical study, Journal of Cranio-maxillofacial Surgery. 2006, 34: 277-82.

 

Researcher : Chien AYJ

List of Research Outputs

 

Chien A.Y.J., She T.T., Jin L.J., McGrath C.P.J. and Corbet E.F., Quality of life and orthodontic correction of incisor drifting, Journal of Dental Research. 2006, 85 (Spec Iss B): 420 (PEF).

 

Researcher : Chiu GKC

List of Research Outputs

 

Chan W.C., Ng C.H., Yiu B.K., Liu C.Y., Ip C.M., Siu H.H., Chiu G.K.C., Hagg E.U.O. and Jin L.J., A survey on the preference for continuing professional dental education amongst general dental practitioners who attended the 26th Asia Pacific Dental Congress, European Journal of Dental Education. 2006, 10: 210-216.

 

Researcher : Chiu WK

Project Title:

Pregabalin versus Carbamazepine for Patients with Neuropathic Orofacial Pain

Investigator(s):

Chiu WK, Cheung CW, Irwin MG

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2006

 

Abstract:

Neuropathic orofacial pain, particularly trigeminal neuralgia is a common and extremely unpleasant and debilitating condition which can severely affect sufferers quaity of life. Carbamazepine is an anticonvulsant blocking sodium channels and is currently the standard treatment for patients with neuropathic orofacial pain. However, its use is frequently limited by side effects such as dizziness, ataxia, marrow suppression, hypersensitivity reaction and liver dysfunction. These are potentially dangerous and close monitoring of complete blood picture, liver function and renal function are essential. Pregabalin (S-enantiomer of 3-aminomethyl-hexanoic acid) is a structural analogue of gamma-aminobutyric acid (GABA) but is functionally unrelated to it. It acts as a ligand at the alpha-2-delta binding site associated with voltage-gated calcium channels in the central nervous system. It is pharmacologically similar to gabapentin which is now well established in the treatment of neuropathic pain. However, it has a superior pharmacological profile: more predictable response with linear pharmacokinetic, higher oral bioavailability, fast onset, lack of drug interactions and better tolerability. Pregabalin has been shown to be effective in the treatment of diabetic neuropathy and post-herpetic neuralgia, and as well been used to treat epilepsy, neuropathic pain and anxiety. It is generally much well tolerated than carbamazepine. Objectives: 1. To evaluate and compare the efficacy of pregabalin and carbamazepine in patients with neuropathic orofacial pain 2. To evaluate and compare the side effects and tolerability of pregabalin and carbamazepine in patients with neuropathic orofacial pain 3. To evaluate the effects of pregabalin and carbamazepine on mood and sleep and quality of life of patients

 

List of Research Outputs

 

Cheung C.W., Ying C.L.A., Chiu W.K., Wong G.T.C., Ng J.K.F. and Irwin M.G., A comparison of dexmedetomidine and midazolam for sedation during wisdom teeth extraction, Anaesthesia. UK, 2007.

 

Chow R.L.K., Singh B..., Chiu W.K. and Samman N., Prevalence of postoperative complications after orthognathic surgery: a 15-year review, Journal of Oral and Maxillofacial Surgery. 2007, 65: p. 984-992.

 

Yeung R.W.K., Samman N., Chow R.L.K. and Chiu W.K., Short-term therapeutic outcome of intra-articular high molecular weight hyaluronic acid injection for non-reducing disc displacement of the temporomandibular joint, Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology & Endodontics. 2006, 102 (4): p. 453-461.

 

Researcher : Chow KF

List of Research Outputs

 

Wat P.Y.P., Chow K.F., Chu F.C.S. and Chow T.W., Modified mandibular complete denture as an interim implant-supported, cement-retained prosthesis: A clinical technique, Clinical Implant Dentistry and Related Research. 2007, 9: 1-5.

 

Researcher : Chow RLK

List of Research Outputs

 

Chow R.L.K., Singh B..., Chiu W.K. and Samman N., Prevalence of postoperative complications after orthognathic surgery: a 15-year review, Journal of Oral and Maxillofacial Surgery. 2007, 65: p. 984-992.

 

Yeung R.W.K., Samman N., Chow R.L.K. and Chiu W.K., Short-term therapeutic outcome of intra-articular high molecular weight hyaluronic acid injection for non-reducing disc displacement of the temporomandibular joint, Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology & Endodontics. 2006, 102 (4): p. 453-461.

 

Yeung R.W.K., Samman N., Cheung L.K., Zhang C...P... and Chow R.L.K., Stereomodel-assisted fibula flap harvest and mandibular reconstruction, Journal of Oral and Maxillofacial Surgery. 2007, 65: p.1128-1134.

 

Yip H.S., Cheung L.K. and Chow R.L.K., Stability and morbidities of Le Fort I osteotomies with bioresorbable fixation - a randomized controlled trial, Asian J Oral Maxillofac Surg. 2006, 18:3 (Suppl 1): p. 61.

 

Yip I.H.S., Cheung L.K. and Chow R.L.K., Stability and morbidities of Le Fort I osteotomies with bioresorbable fixation - a randomized controlled trial, 20th Annual Scientific Meeting, Faculty od Dentistry, The University of Hong Kong. 2006, p.16.

 

Yip I.H.S., Cheung L.K. and Chow R.L.K., Stability and morbidities of Le Fort I osteotomies with bioresorbable fixation - a randomized controlled trial, Journal of Cranio-Maxillofacial Surgery. 2006, 34 (Suppl. S1): p. 115.

 

Researcher : Chow TW

List of Research Outputs

 

Chai J.Y.C., Chu F.C.S., Chow T.W., Shum N.C. and Hui W.W.H., Best Paper Award, Equal first 3 papers in International Journal of Prosthodontics in 2006, International Journal of Prosthodontics. 2007.

 

Chow T.W., Performance of Small Diameter Implants, Joint Scientific Program of Quincentenary Celebration of Royal College of Surgeons of Edinburgh and College of Surgeons of Hong Kong. 2006.

 

Chow T.W., The Dental Faculty Overseas Gold Medal for distinguished contributions to the Faculty and Dentistry, The Dental Faculty, Royal College of Surgeons of Edinburgh. 2006.

 

Chow T.W., Visiting Professor, Guanghua College of Stomatology, Sun Yat-sen University. 2007.

 

Wat P.Y.P., Chow K.F., Chu F.C.S. and Chow T.W., Modified mandibular complete denture as an interim implant-supported, cement-retained prosthesis: A clinical technique, Clinical Implant Dentistry and Related Research. 2007, 9: 1-5.

 

Researcher : Chu FCS

Project Title:

A microbiological study of bone collected during immediate dental implant surgery

Investigator(s):

Chu FCS, Tsang PCS, Chow TW

Department:

Dental Faculty

Source(s) of Funding:

Low Budget High Impact Programme

Start Date:

11/2001

 

Abstract:

To compare the microbial contamination of bone collected from surgical sites with at least healing period of four weeks, and from fresh extraction sockets prepared for dental implants; to determine if bone grafts have to be collected from areas other than fresh extraction sockets; to identify if particular pre-extraction conditions.

 

List of Research Outputs

 

Chai J.Y.C., Chu F.C.S., Chow T.W., Shum N.C. and Hui W.W.H., Best Paper Award, Equal first 3 papers in International Journal of Prosthodontics in 2006, International Journal of Prosthodontics. 2007.

 

Chu F.C.S., Aesthetic Dental Restorations, Joint Scientific Program of Quincentenary Celebration of Royal College of Surgeons of Edinburgh and College of Surgeons of Hong Kong. 2006.

 

Chu F.C.S., Member, Scientific Advisory Committee, Journal of Endodontics. 2006.

 

Chu F.C.S., Visiting Associate Professor, Guanghua College of Stomatology, Sun Yat-sen University. 2007.

 

Wat P.Y.P., Chow K.F., Chu F.C.S. and Chow T.W., Modified mandibular complete denture as an interim implant-supported, cement-retained prosthesis: A clinical technique, Clinical Implant Dentistry and Related Research. 2007, 9: 1-5.

 

Researcher : Chua HDP

List of Research Outputs

 

Bendeus S.A.M., Chua H.D.P. and Cheung L.K., The role of orthodontics in maxillary distraction of cleft patients., Transaction of 3rd Asia Pacific Congress on Craniofacial Distraction Osteogenesis. 2007, p. 177-8.

 

Cheung L.K., Chua H.D.P. and Bendeus S.A.M., Cleft Maxillary Distraction versus Orthognathic Surgery: Clinical Morbidities and Surgical Relapse , Plast Reconstr Surg . 2006, 118: 996-1008.

 

Cheung L.K., Chua H.D.P., Whitehill T.L., Ho M.Y., Bendeus S.A.M. and Samman N., Cleft distraction versus orthognathic surgery - which is more stable? , XVIII Congress of the European Association for Cranio-Maxillo facial Surgery, Barcelona, Spain. 2006.

 

Cheung L.K. and Chua H.D.P., Maxillary distraction for patients with cleft lip and palate, In: William H. Bell, César A. Guerrero, Distraction Osteogenesis of the Facial Skeleton. BC Decker Inc, Hamilton, 2007, p. 529-542.

 

Chua H.D.P., Whitehill T.L., Samman N. and Cheung L.K., Cleft distraction versus orthognathic surgery - which one cause less disturbance on resonance?, J Cranio-maxillofac Surg. 2006, 34 (suppl. S1): p. 37.

 

Chua H.D.P., Ho M.Y. and Cheung L.K., Cleft distraction versus orthognathic surgery - which one causes more distress?, J Cranio-maxillofac Surg. 2006, 34 (suppl. S1): p. 12.

 

Chua H.D.P. and Cheung L.K., Distraction osteogenesis for the cranio-maxillofacial region (I): a compendium of devices for the maxilla and midface, Asian J Oral Maxillofac Surg. 2006, 18: 248-58.

 

Chua H.D.P., Bendeus S.A.M. and Cheung L.K., Distraction osteogenesis versus orthognathic surgery in CLP patients, Transaction of 3rd Asia Pacific Congress on Craniofacial Distraction Osteogenesis.. 2007, p.163-164.

 

Chua H.D.P., Bendeus S.A.M. and Cheung L.K., Long term stability of cleft distraction osteogenesis versus orthognathic surgery, 20th Annual Scientific Meeting, Faculty of Dentistry, The University of Hong Kong. 2006, p. 17.

 

Chua H.D.P., Bendeus S.A.M. and Cheung L.K., Long-term stability of ceft distraction osteogenesis versus orthognathic surgery (Winner of best oral presentation), Asian J Oral Maxillofac Surg. 2006, 18:3 (suppl 1): p. 34.

 

Chua H.D.P., Bendeus S.A.M. and Cheung L.K., Oral Presentation: Long-term Stability of Cleft Distraction Osteogenesis versus Orthognathic Surgery. , 20th Annual Scientific Meeting of the Faculty of Dentistry. 15th December, 2006; The Prince Philip Dental Hospital.. 2006, 17.

 

Researcher : Chua HDP

List of Research Outputs

 

Bendeus S.A.M., Chua H.D.P. and Cheung L.K., The role of orthodontics in maxillary distraction of cleft patients., Transaction of 3rd Asia Pacific Congress on Craniofacial Distraction Osteogenesis. 2007, p. 177-8.

 

Cheung L.K., Chua H.D.P. and Bendeus S.A.M., Cleft Maxillary Distraction versus Orthognathic Surgery: Clinical Morbidities and Surgical Relapse , Plast Reconstr Surg . 2006, 118: 996-1008.

 

Cheung L.K., Chua H.D.P., Whitehill T.L., Ho M.Y., Bendeus S.A.M. and Samman N., Cleft distraction versus orthognathic surgery - which is more stable? , XVIII Congress of the European Association for Cranio-Maxillo facial Surgery, Barcelona, Spain. 2006.

 

Cheung L.K. and Chua H.D.P., Maxillary distraction for patients with cleft lip and palate, In: William H. Bell, César A. Guerrero, Distraction Osteogenesis of the Facial Skeleton. BC Decker Inc, Hamilton, 2007, p. 529-542.

 

Chua H.D.P., Whitehill T.L., Samman N. and Cheung L.K., Cleft distraction versus orthognathic surgery - which one cause less disturbance on resonance?, J Cranio-maxillofac Surg. 2006, 34 (suppl. S1): p. 37.

 

Chua H.D.P., Ho M.Y. and Cheung L.K., Cleft distraction versus orthognathic surgery - which one causes more distress?, J Cranio-maxillofac Surg. 2006, 34 (suppl. S1): p. 12.

 

Chua H.D.P. and Cheung L.K., Distraction osteogenesis for the cranio-maxillofacial region (I): a compendium of devices for the maxilla and midface, Asian J Oral Maxillofac Surg. 2006, 18: 248-58.

 

Chua H.D.P., Bendeus S.A.M. and Cheung L.K., Distraction osteogenesis versus orthognathic surgery in CLP patients, Transaction of 3rd Asia Pacific Congress on Craniofacial Distraction Osteogenesis.. 2007, p.163-164.

 

Chua H.D.P., Bendeus S.A.M. and Cheung L.K., Long term stability of cleft distraction osteogenesis versus orthognathic surgery, 20th Annual Scientific Meeting, Faculty of Dentistry, The University of Hong Kong. 2006, p. 17.

 

Chua H.D.P., Bendeus S.A.M. and Cheung L.K., Long-term stability of ceft distraction osteogenesis versus orthognathic surgery (Winner of best oral presentation), Asian J Oral Maxillofac Surg. 2006, 18:3 (suppl 1): p. 34.

 

Chua H.D.P., Bendeus S.A.M. and Cheung L.K., Oral Presentation: Long-term Stability of Cleft Distraction Osteogenesis versus Orthognathic Surgery. , 20th Annual Scientific Meeting of the Faculty of Dentistry. 15th December, 2006; The Prince Philip Dental Hospital.. 2006, 17.

 

Researcher : Corbet EF

List of Research Outputs

 

Chien A.Y.J., She T.T., Jin L.J., McGrath C.P.J. and Corbet E.F., Quality of life and orthodontic correction of incisor drifting, Journal of Dental Research. 2006, 85 (Spec Iss B): 420 (PEF).

 

Corbet E.F., Dental Faculty Overseas Medal, Royal College of Surgeons of Edinburgh. 2006.

 

Corbet E.F., Editorial Board, Clinical Oral Implants Research. 2006.

 

Corbet E.F., Editorial Board, European Journal of Dental Education. 2006.

 

Corbet E.F., Editorial Board, Journal of Periodontal Research. 2006.

 

Corbet E.F., Honorary Editorial Advisor, Hong Kong Dental Journal. 2006.

 

Corbet E.F., Invited lecture, "A symposium on periodontal aspects of systemic health", Dental Tribune & Royal Australasian College of Dental Surgeons, Sydney, Australia, August 10. 2006.

 

Corbet E.F., Invited lecture, "Dental implants in periodontally susceptible patients", 1st International Dental Health Forum of Fes, Morocco, March 17. 2007.

 

Corbet E.F., Invited lecture, "Do bone or bone substitute grafts improve periodontal surgical outcomes", 1st Asia Bone Symposium, Hong Kong, October 25. 2006.

 

Corbet E.F., Invited lecture, "Implant reconstructions in the periodontally involved", Annual Congress of the Academy of Oral Implanatology, Taipei, Taiwan, September 29. 2006.

 

Corbet E.F., Invited lecture, "Management of the Peri-Implant Lesions", The 1st ITI Asia Congress, Shanghai, China, December 3. 2006.

 

Corbet E.F., Periodontal Diseases in Asians, Journal of the International Academy of Periodontology. 2006, 8: 136-144.

 

Corbet E.F., Public Health Aspects of Oral Diseases and Disorders - Periodontal Diseases. In Community Oral Health, ed. Cynthia Pine and Rebecca Harris, Community Oral Health. Surrey, Quintessence, 2007, 177-189.

 

Corbet E.F., Reviewer, International Dental Journal. 2006.

 

Corbet E.F., Reviewer, Oral Health and Preventive Dentistry. 2006.

 

Corbet E.F., Reviewer, Quintessence International. 2006.

 

Lo E.C.M., Luo Y., Tan H., Dyson J.E. and Corbet E.F., Art and conventional root restorations in elders after 12 months, Journal of Dental Research. 2006, 85: 929-932.

 

Luo Y., Lo E.C.M., Tan H., Dyson J.E. and Corbet E.F., ART and conventional root restorations in elders after 3 years, Journal of Dental Research. 2007, 86 (Spec Iss A): 2435.

 

Zee K.Y., Lee D.H. and Corbet E.F., Repeated oral hygiene instructions alone, or in combination with metronidazole dental gel with or without subgingival scaling in adult periodontitis patients: A one-year clinical study, Journal of the International Academy of Periodontology. 2006, 8: 125-135.

 

Researcher : Dai J

List of Research Outputs

 

Dai J. and Rabie A.B.M., Direct AAV-mediated gene delivery to the temporomandibular jonit, Frontiers in Bioscience. 2007, 12: 2212-2220.

 

Dai J. and Rabie A.B.M., RAAV-mediated gene delivery to the mandibular condyle, 82nd Congress of the European Orthodontic Society. 2006.

 

Dai J. and Rabie A.B.M., Recombinant adeno-associated virus vector hybrids efficiently target different skeletal cells, Frontiers in Bioscience. 2007, 12: 4280-4287.

 

Dai J. and Rabie A.B.M., The use of recombinant adeno-associated virus for skeletal gene therapy, Orthodontics Craniofacial Research. 2007, 10: 1-14.

 

Rabie A.B.M. and Dai J., Infection efficiency of rat chondrocyties using different hybrids of RAAV vectors, 82nd Congress of the European Orthodontic Society. 2006.

 

Rabie A.B.M., Dai J. and Xu R., Recombinant AAV-mediated VEGF gene therapy induces mandibular condylar, Gene Therapy. 2007, 14: 978-980.

 

Researcher : Darvell BW

List of Research Outputs

 

Chan B.Y., Dyson J.E. and Darvell B.W., Operator force vector measurement in clinical dental cutting procedures, 20th Annual Scientific Meeting, Faculty of Dentistry, The University of Hong Kong. 2006, 20: P21.

 

Chan Y.P., Tang C.Y., Darvell B.W. and Tsui C.P., Effect of filler shape and volume fraction on strain damage of particulate-reinforced dental composites, Materials Science Forum. Switzerland, Trans Tech Publications Ltd, 2006, 532-533: 117-120.

 

Chan Y.P., Tang C.Y., Darvell B.W. and Tsui C.P., Effect of filler shape and volume fraction on strain damage of particulate-reinforced dental composites, The 12th International Manufacturing Conference, Xi'an, Sept. 2006.

 

Cheung G.S.P. and Darvell B.W., "Low-cycle fatigue of Ni-Ti rotary instrument", 14th Asian Pacific Endodontic Confederation Scientfic Session (April '07), Jakarta, Indonesia. 2007.

 

Cheung G.S.P., Bian Z., Shen Y., Peng B. and Darvell B.W., Comparison of defects in ProTaper hand-operated and engine-driven instruments after clinical use, International Endodontic Journal. 2007, 40: 169-178.

 

Cheung G.S.P. and Darvell B.W., Predicting the fatigue life of NiTi instruments in use, Endodontic Bulletin. 2006, 17: 17-23.

 

Darvell B.W., A Glossary of Terms for Dental Materials Science 9th edition. Hong Kong, B W Darvell, 2006, i + 133.

 

Darvell B.W., Dental Materials Science - Critical Appraisal of the Literature, Dental Asia. 2006, 2 (July issue): 49-51.

 

Darvell B.W., Dental Materials Science - Enigma: Variations on a Theme, Dental Asia. 2006, 2 (Sept issue): 48-51.

 

Darvell B.W., Dental materials Science - The Coda: R-E-S-P-E-C-T (repeat and fade), Dental Asia. 2006, 2 (Nov issue): 58-61.

 

Darvell B.W., Materials Science for Dentistry, 8th edition, Hong Kong, B W Darvell, 2007, xv + 598.

 

Darvell B.W. and Dias A.P.L.H., Non-inverse-square force-distance law for long thin magnets, Dental Materials. Elsevier Ltd., 2006, 22: 909-918.

 

Li Q.L., Chen Z.Q., Darvell B.W., Zeng Q., Li G., Ou G.M. and Wu M.Y., Biomimetic synthesis of PEC-HA composite analogous to bone, Key Eng. Mater.. 2007, 336-338: 1699-1702.

 

Li Q.L., Chen Z.Q., Darvell B.W., Zeng Q., Li G., Ou G.M. and Wu M.Y., Biomimetic synthesis of the composites of hydroxyapatite and chitosan-phosphorylated chitosan polyelectrolyte complex, Materials Letters. 2006, 60: 3533-3536.

 

Lung C.Y.K. and Darvell B.W., Methyl methacrylate monomer-polymer equilibrium in solid polymer, Dental Materials. Elsevier Ltd., 2007, 23: 88-98.

 

Musanje L. and Darvell B.W., Curing-light attenuation in filled-resin restorative materials, Dental Materials. 2006, 22: 804-817.

 

Pan H. and Darvell B.W., Tetracalcium phosphate and brushite solubility by solid titration, 85th General Session & Exhibition of the IADR, New Orleans, Louisiana, USA, 21-24 March 2007. abstract 1076.

 

Wang Q., Huang W.H., Wang D.P., Darvell B.W., Day D.E. and Rahaman M.N., Preparation of hollow hydroxyapatite microspheres, J. Mater. Sci.: Mater. Med.. 2006, 17: 641-646.

 

Wu C.T. and Darvell B.W., Necessity of benzoyl peroxide for heat-processed denture-base acrylic, 85th General Session & Exhibition of the IADR, New Orleans, Louisiana, USA, 21-24 March 2007. abstract 1600.

 

Researcher : Dassanayake RS

List of Research Outputs

 

Samaranayake Y.H., Dassanayake R.S., Cheung B.P.K., Jayatilake J.A.M.S., Yeung S.K.W., Yau J.Y.Y. and Samaranayake L.P., Differential phospholipase gene expression by Candida albicans in artificial media and cultured human oral epithelium, APMIS. 2006, 114: 857-66.

 

Researcher : Dyson JE

List of Research Outputs

 

Chan B.Y., Dyson J.E. and Darvell B.W., Operator force vector measurement in clinical dental cutting procedures, 20th Annual Scientific Meeting, Faculty of Dentistry, The University of Hong Kong. 2006, 20: P21.

 

Dyson J.E., Pain and joy of curriculum reform, Curriculum seminar. Centre for the Advancement of University Teaching, University of Hong Kong. 2006.

 

Dyson J.E., Replication techniques in complete denture construction, Oral Health and Science Seminar, Faculty of Dentistry, University of Hong Kong. 2007.

 

Lo E.C.M., Luo Y., Tan H., Dyson J.E. and Corbet E.F., Art and conventional root restorations in elders after 12 months, Journal of Dental Research. 2006, 85: 929-932.

 

Luo Y., Lo E.C.M., Tan H., Dyson J.E. and Corbet E.F., ART and conventional root restorations in elders after 3 years, Journal of Dental Research. 2007, 86 (Spec Iss A): 2435.

 

Researcher : Guo J

List of Research Outputs

 

Yip H.K., Guo J. and Wong W.S., Incipient caries lesions on cementum by mono- and co-culture oral biofilms, Journal of Dentistry. 2007, 35: 377-382.

 

Yip H.K., Guo J. and Wong W.H.S., Protection offered by root surface restoratives against biofilm challenge, Journal of Dental Research. 2007, 86: 431-435.

 

Researcher : Hagg EUO

Project Title:

Temporo-mandibular joint adaptation to extended mandibular forward positioning in two phases separated by a rest period. An experimental study

Investigator(s):

Hagg EUO, Rabie ABM

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2002

 

Abstract:

To reveal the molecular control mechanism of temporo-mandibular joint adaptation in response to extended mandibular forward positioning in two phases separated by a rest period.

 

Project Title:

Biological responses of mandibular condyle to bite-jumping in adult rats

Investigator(s):

Hagg EUO, Rabie ABM, Xiong H

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2003

 

Abstract:

To explore the biological responses of mandibular condyle to bite-jumping in adult rats.

 

Project Title:

The effects of buguzhi on osteogenesis

Investigator(s):

Hagg EUO, Rabie ABM, Wong RWK

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

 

Abstract:

To investigate the effects of Buguzhi, a kind of traditional Chinese medicine, on osteogenesis.

 

Project Title:

A case-control study of treated and untreated severe incisor overjet on quality of life of adolescents and adults : a multi-centre cohort study

Investigator(s):

Hagg EUO, McGrath CPJ

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

10/2005

 

Abstract:

Objectives :1) to assess the impact of oral health on quality of life of adolescents and adults in China with severe incisor overjet;2 )to assess the impact of oral health on quality of life of adolescents and adults in China whose severe overjet have been treated;3) to determine differences in the impact of oral health on quality of life among adolescents and adults in China, between those treated and untreated. In addition, to identify factors (socio-demographic and clinical) associated the difference in oral health, related quality of life.

 

Project Title:

In vitro study of Traditional Chinese Medicine (TCM) extracts on common Biofilm forming organisms

Investigator(s):

Hagg EUO, Wong RWK, Samaranayake LP

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

01/2007

 

Abstract:

Plaque biofilms develop on all natural shedding and non-shedding surfaces of the oral cavity, as well as on foreign materials introduced into this milieu. The presence of biofilms can be attributed as the causative factor of many oral infections including caries periodontal disease and candidiasisInvisalign appliances are a newly developed form of plastic splints worn, in the mouth for orthodontic purposes for prolonged periods The appliance works on a similar principle to post-treatment tooth aligners, with the `teeth` in the appliance deliberately set up to a desired altered position, and pressure from the plastic of the appliance causing the desired tooth movement. Invisalign patients generally wear 24-30 sets of these clear, medical grade polycarbonate aligners during a course of treatment, full time (except for meals and oral hygiene) for periods of 2 weeks per alignerThe objectives of this study are to evaluate the effect of various TCM extracts on commonly found biofilm bacteria, growing on the Invisalign orthodontic appliance. The effect of the extracts will be determined based on the MIC as well as time fast effectiveness of the extracts against commonly found bacteria.

 

List of Research Outputs

 

Bendeus S.A.M., Hagg E.U.O. and Wong R.W.K., Bracing for the future, Faculty Expressions 2006. 2006, 9.

 

Bendeus S.A.M., Phan M. and Hagg E.U.O., Poster:Presentation: A comparison of changes of overjet and jaw- base relationship in treatment with removable and fixed functional appliance. , The Second Cross-Strait Four Regions Orthodontic Conference, Nanjing, China, 19 – 21 November, 2006. . 2006.

 

Chan W.C., Ng C.H., Yiu B.K., Liu C.Y., Ip C.M., Siu H.H., Chiu G.K.C., Hagg E.U.O. and Jin L.J., A survey on the preference for continuing professional dental education amongst general dental practitioners who attended the 26th Asia Pacific Dental Congress, European Journal of Dental Education. 2006, 10: 210-216.

 

Deng Y.M. and Hagg E.U.O., An Update on Clinical Use of Self-Ligating Bracket System (Part I), Dental Asia. 2007, 19-30.

 

Deng Y.M. and Hagg E.U.O., An update on clinicaluse of self-ligating bracket system (Part II), Dental Asia. 2007, 18-21.

 

Hagg E.U.O., Song Y. and Rabie A.B.M., Microarray analysis of chondrogenic genes in condylar cartilage, 82nd Congress of the European Orthodontic Society. 2006.

 

Hou H.M., Hagg E.U.O., Sam K., Rabie A.B.M., Wong R.W.K., Lam B. and Ip M.S.M., Dentofacial Characteristics of Chinese Obstructive Sleep Apnea Patients in Relation to Obesity and Severity, The Angle Orthodontist. 2006, 76 No.6: 962-969.

 

Hou H.M., Wong R.W.K. and Hagg E.U.O., The uses of orthodontic study models in diagnosis and treatment planning , Hong Kong Dental Journal. 2006, Vol. 3 No..2: 107-115.

 

Ikegami T., Wong R.W.K. and Hagg E.U.O., A hybrid orthodontic treatment system, 83rd Congress of the European Orthodontic Society, Berlin, Germany, 20-24 June. 2007.

 

Mok C.W., Zhou L., McGrath C.P.J., Hagg E.U.O. and Bendeus S.A.M., Agreement between study casts and their images in assessing of malocclusion and treatment need. , The Second Cross-Strait Four Regions Orthodontic Conference, Nanjing, China. 18-21 November, 2006.

 

Mok C.W., Zhou L., McGrath C.P.J., Hagg E.U.O. and Bendeus S.A.M., Poster Presentation: Agreement between study casts and their images in assessing of malocclusion and treatment need. , 20th Annual Scientific Meeting of the Faculty of Dentistry. 15th December, 2006; The Prince Philip Dental Hospital.. 2006.

 

Ng F.S.A., Hagg E.U.O. and Wong R.W.K., Facial Asymmetry. The Orthodontist's Viewpoint, Dental Asia January/ February 2007 issue. 2007, 19-24.

 

Phan K.L.D., Bendeus S.A.M., Hagg E.U.O., Hansen K. and Rabie A.B.M., Comparison of the headgear activator and Herbst appliance - effects and post-treatment changes, European Journal of Orthodontics. 2006, 28 No.1: 594-604.

 

Rabie A.B.M., Hagg E.U.O., Wong R.W.K. and Al K.A.A.A., Indian Hedgehog is a mechanotransduction mediator in mandibular condyles., Biological Mechanisms of Tooth Eruption, Resorption, and Movement - Proceedings of the Eighth International Conference, Phuket, Thailand, 2005. Eds. Davidovitch Z., Mah J. and Suthanarak S., University of South California, School of Dentistry . 2006, 179-189.

 

Wey M.C., Bendeus S.A.M., Peng L., Hagg E.U.O., Rabie A.B.M. and Robinson W., Stepwise advancement versus maximum jumping with headgear activator, European Journal of Orthodontics. 2007, 29: 283-293.

 

Wong L., Hagg E.U.O. and Wong G., Correction of extreme overjet in 2 phases, American Journal of Orthodontics & Dentofacial Orthopedics. 2006, 130 No. 4: 540-548.

 

Wong R.W.K., Rabie A.B.M. and Hagg E.U.O., The Effect of Crude Extract from Radix Dipsaci on Bone in Mice, Phytotherapy Research. 2007, 21: 596-598.

 

Wong R.W.K., Shum L.M.Y. and Hagg E.U.O., The Gold Medal of the Conjoint M.Orth Examination of the Royal College of Surgeons of Edinburgh, Surgical Orthodontic Cases., Journal of Orthodontic. 2006, 33: 172-184.

 

Wu J., Hagg E.U.O. and Rabie A.B.M., Chinese norms of McNamara's cephalometric analysis, Angle Orthodontist. 2007, 77: 12-20.

 

Zhang M., McGrath C.P.J. and Hagg E.U.O., Patients' expectations and experiences of fixed orthodontic appliance therapy, Angle Orthodontist. 2007, 77: 318-322.

 

Zhang M., McGrath C.P.J. and Hagg E.U.O., The impact of malocclusion and its treatment on quality of life: a literature review, International Journal of Paediatric Dentistry. 2006, 16: 381-387.

 

Zhang M., McGrath C.P.J. and Hagg E.U.O., Who knows more about the impact of malocclusion on children's quality of life, mothers or fathers?, European Journal of Orthodontics. 2007, 29: 180-185.

 

Zhou L., Mok C.W., Hagg E.U.O., McGrath C.P.J. and Bendeus S.A.M., Poster Presentation: Dentofacial characteristics among Hong Kong Chinese children in different occlusion catergories., The Second Cross-Strait Four Regions Orthodontic Conference, Nanjing, China. 18-21 November, 2006. . 2006.

 

Zhou L., Mok C.W., Hagg E.U.O., McGrath C.P.J. and Bendeus S.A.M., Poster Presentation: Sagittal dental arch relationship versus anteroposterior skeletal pattern among 12-years-old Hong Kong Chinese Children., 20th Annual Scientific Meeting of the Faculty of Dentistry. 15th December, 2006; The Prince Philip Dental Hospital.. 2006.

 

Researcher : Hiraishi N

List of Research Outputs

 

Hiraishi N., Yiu C.K.Y. and King N.M., Bonding strength on dentin from primary tooth with amelogenesis imperfecta, International Journal of Paediatric Dentistry. 2007, 17: P.17.

 

Yiu C.K.Y., Hiraishi N. and King N.M., Bond strength of self-etch adhesives to bur-cut dentin, International Journal of Paediatric Dentistry. 2007, 17: P.18.

 

Yiu C.K.Y., Hiraishi N. and King N.M., Effect of dentinal surface preparation on bond strength of self-etch adhesives, 20th Annual Scientific Meeting of the Faculty of Dentistry, Faculty of Dentistry, The Universlity of Hong Kong. 2006.

 

Researcher : Itthagarun A

Project Title:

New concepts for selective removal of carious dentition

Investigator(s):

Itthagarun A, King NM, Tay FRCM

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

 

Abstract:

To evaluate and compare the bonding efficacy of cavities prepared by 'SmartPrep' & 'CalrisolvTM on primary teeth, with those prepared by a conventional bur; to evaluate and compare the bonding efficacy of cavities prepared by 'CalrisolvTM, on primary teeth, with those prepared by a conventional bur; to evaluate and compare the bonding efficacy of cavities prepared, in primary teeth, by 'SmartPrep' with those prepared by CarisolvTM.

 

Project Title:

The effect of R.O.C.S (remineralizing oral care system) toothpaste on artificial caries like lesions: An in vitro pH cycling study.

Investigator(s):

Itthagarun A, King NM, Rana R

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

10/2005

 

Abstract:

Recent advances in the technique of processing microradiographs by computer-aided image analysis allow the mineral profiles of enamel lesions to be assessed with great accuracy (Strang et al., 1987; Heaven et al., 1990; Chow et al., 1992). It is now possible to measure small changes in these profiles following exposure of the lesions to demineralization and/or remineralization in laboratory models, as well as in the oral environment (Strang et al., 1986). Unfortunately, the comparison of experimental and control sections is hampered by the biological variation in the enamel itself, especially by inhomogeneous lesions, even when they are prepared under standardized conditions (Strang et al., 1986). Several research groups have developed a 'single section technique', mainly for the purpose of determining differences between pre- and post experimental profiles at exactly the same spot (Creanor et al., 1986; Mellberg et al., 1986; Wefel et al., 1987). Since thin sections can be repeatedly subjected to microradiographic assessment during or between experimental treatments, this technique offers the possibility of determining time-dependent changes in lesion profiles resulting from localized dissolution or deposition of enamel. It may thus help to resolve the mechanisms which underlie the formation of subsurface lesions and laminations (Driessens et al., 1986; Palamara et al., 1986; Sato and Yamamoto, 1986), and the effects of both caries-protective agents and inhibitors of remineralization.Ten Cate and Duijsters (1982) developed a so-called 'pH cycling model' involving tooth enamel and intra-oral-like conditions of de/remineralization solution, and pH ranges. This in vitro technique has been widely accepted because it can simulate in vivo situations more closely than traditional experimental studies. Since then, many researchers have adopted and modified such pH cycling methods to use in both enamel and root lesion experiments (Featherstone, 1983; Ten Cate et al., 1988; Heilman et al., 1991; Itthagarun et al., 1997). The version developed by Itthagarun et al., has been used extensively to evaluate remineralizing agents in toothpaste, chewing gums and lozenges (Itthagarun et al., 1999; 2000; 2004; 2005). Recently R.O.C.S toothpastes (Remineralizing oral care systems, DRC Ltd, Moscow, Russia) have been marketed for school children and adults. It has been claimed by the company that these toothpastes 'accelerate the formation of enamel' and 'primary caries focus is enriched with minerals'. The main active ingredients of R.O.C.S. for school-children are complex AMIFLUOR® (minerals) with fluorine and xylitol, while the R.O.C.S toothpaste intend for use by adults contains MINERALIN® and bromelaine, a source of calcium, phosphorus and magnesium. Currently, no published data are available in the English literature. Xylitol has been found to induce remineralization of demineralized enamel by facilitating calcium movement and accessibility (Miake et al, 2003). It also raises the pH of saliva and changes both the quantity and quality of saliva, thus aiding the remineralization process.Bromelaine has been found to provide an anti-inflammatory effect and has been used in medicine and in dentistry, following third molar extractions (Hotz et al, 1989) Consequently, the essence of the remineralizing concept of R.O.C.S. might be achieved by simultaneously supplying calcium, phosphate, and fluoride ions to the teeth in order to induce the formation of calcium fluoroapatite which remineralizes and strengthens the tooth (Torrado et al, 2004). However, as no evidence on the remineralization effects of R.OC.S toothpaste has been published in the English literature, it is appropriate to evaluate the remineralizing effects claimed and also to determine the mechanics involved. Objectives of the study:The aims of this in vitro pH cycling study is to use the single-section technique together with our modified pH cycling model to evaluate the effects of R.O.C.S schooldchildren and R.O.C.S adult toothpastes on the remineralization of enamel artificial caries-like lesions. Their remineralization efficacy will also be compared with that of a standard fluoride toothpastes intended for both children and adults.Key issues and problems to be addressed:Hypothesis to be testedo The new R.O.C.S. toothpastes for children will enhance remineralization of initial carious lesions in tooth enamel more effectively than non-fluoride child toothpaste o The new R.O.C.S. toothpastes for children will show similar 'healing' efficacy of the enamel initial cariuos lesions when compared to that of a standard fluoride toothpaste for children (500ppmF)o The new R.O.C.S. toothpastes for adults will enhance remineralization of initial carious lesion in tooth enamel more effectively than non-fluoride toothpasteo The new R.O.C.S. toothpastes for adults will show similar 'healing' efficacy of the enamel initial carious lesions when compared to that of the standard fluoride toothpaste for adults (1000ppmF)

 

List of Research Outputs

 

Itthagarun A., King N.M. and Yiu C.K.Y., Paediatric Dentistry in Hong Kong, Expressions (Newsletter of the HKU Faculty of Dentistry). 2007, Issue 1: 11.

 

King N.M., Anthonappa R.P. and Itthagarun A., The importance of the primary dentition to children - Part 1: consequences of not treating carious teeth., The Hong Kong Practitioner. 2007, 29: 52-61.

 

King N.M., Anthonappa R.P. and Itthagarun A., The importance of the primary dentition to children - Part 2: effects of treating carious teeth by extraction, The Hong Kong Practitioner. 2007, 29: 101-107.

 

Yiu C.K.Y., King N.M. and Itthagarun A., Good beginnings, Expressions (Newsletter of the HKU Faculty of Dentistry). 2007, Issue 1: 11.

 

Researcher : Jayatilake JAMS

List of Research Outputs

 

Jayatilake J.A.M.S., Samaranayake L.P., Lu Q. and Jin L.J., IL-Ia, IL-Ira and IL-8 are differentially induced by Candida in experimental oral candidiasis, Oral Diseases. Blackwell Munksgaard, 2007, 13: 426-433.

 

Reichart P.A., Samaranayake L.P., Bendick C.H..., Schmidt-Westhausen A.M. and Jayatilake J.A.M.S., Prevalence of oral Candida species in leprosy patients from Cambodia and Thailand, Journal of Oral Pathology and Medicine. Blackwell Munksgard, 2007, 36: 342-346.

 

Samaranayake Y.H., Dassanayake R.S., Cheung B.P.K., Jayatilake J.A.M.S., Yeung S.K.W., Yau J.Y.Y. and Samaranayake L.P., Differential phospholipase gene expression by Candida albicans in artificial media and cultured human oral epithelium, APMIS. 2006, 114: 857-66.

 

Researcher : Jin LJ

Project Title:

Multi-factorial Periodontal Risk Spider-web (PRS) for periodontal assessment in Hong Kong Chinese

Investigator(s):

Jin LJ, Corbet EF

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

12/2005

 

Abstract:

Periodontal disease is a family of related diseases that differ in etiology, natural history, disease progression and response to therapy but they share a common underlying chain of pathogenic events (Page et al 1997a,b). Plaque-induced periodontal diseases have traditionally been divided into two general categories: gingivitis and periodontitis. Plaque-induced gingivitis is the presence of gingival inflammation without loss of connective tissue attachment, while plaque-induced periodontitis is the presence of gingival inflammation at sites where there has been apical migration of the attachment onto the root surfaces accompanied by loss of connective tissue and alveolar bone (Armitage 2004). The primary clinical features of periodontitis include clinical attachment loss, alveolar bone loss, periodontal pocketing, and gingival inflammation (Flemmig 1999). In addition, enlargement or recession of the gingiva, bleeding on probing, and increased mobility, drifting, and/or tooth exfoliation may occur (Page & Schroeder 1976). With few exceptions, most forms of periodontitis are chronic inflammation that may progress continuously or by bursts of activity (Socransky et al., 1984; Löe et al., 1986; Jeffcoat et al., 1991). Human periodontitis is initiated and perpetuated by a small group of predominantly gram-negative, anaerobic or microaerophilic bacteria that colonize the subgingival area (Darveau et al., 1997; Page et al., 1997a,b; Flemmig 1999; Corbet & Jin 2004). Indeed, at the 1996 World Workshop on Clinical Periodontics, it was concluded that most of the periodontitis is caused by Porphyromonas gingivalis, Tannerella forsythensis (formerly Bacteroides forsythus) and Actinobacillus actinomycetemcomitans (American Academy of Periodontology 1996). In the last decade, we have come to realize that, although bacteria are essential, they are insufficient for the disease to occur nor responsible to the severity of the disease (Page et al., 1997). Manifestation and progression of periodontitis is influenced by a wide variety of determinants and risk factors, including subject characteristics, social and behavioral factors, systemic factors, genetic factors, tooth-level factors, microbial composition of dental plaque, and other emerging risk factors. Host factors such as inheritance, tobacco smoking and various other risk factors may even outweight the bacteria as determinants of whether the disease occurs and of the severity of disease outcome (Kornman et al., 1997; Page et al., 1997b; Nunn 2003; Page et al., 2003; Persson et al., 2003a,b; Corbet & Jin 2004). It has recently been shown that variations in genotypes of inflammatory cytokines and mediators may be independent risk factors for severe periodontitis, such as IL-1A and IL-1B (Kornman & di Giovine 1998) in chronic periodontitis; and IL-1RN (Parkhill et al., 2000), TNF-A (Galbraith et al., 1998) and IL-10.G (Hennig et al., 2000) in aggressive periodontitis. We recently found that a single nucleotide polymorphism in the MMP-1 promoter region of –1607 bp may be associated with generalized aggressive periodontitis in Chinese population (Cao et al., 2005). In addition, the contribution of periodontal pathogens to halitosis has been established in many studies (Lee et al., 2003; Tanaka et al., 2004; Figueiredo et al., 2005). The relationship between obesity and periodontal disease has recently been reported in Japanese and American populations (Saito et al., 2001; Al-Zahrani et al., 2003). Thus, the concept of multiple periodontal risk factors may induce a great impact on the understanding of the etiology, pathogenesis, prevention and treatment of periodontal disease. Risk is defined as the probability that an event will occur in the future, or the probability that an individual develops a given disease or experiences a change in health status during a specified interval of time (Kornman et al., 1997). A risk factor is any characteristic, behavior, or exposure with an association to a particular disease. The relationship is not necessarily causal in nature (Brownson & Pettiti 1998). From periodontal point of view, that is any factors which increase the probability of developing periodontitis, or lead to a measurable change (tooth loss) in the status of the periodontal supporting tissues (Albandar 2002). It is clear that periodontal risk assessment is potentially providing profound social and economical benefits with regard to disease prevention and control. It would be of great value for better caring of individual risk patient and determination of community treatment needs (Attström et al., 1994; Albandar 2002; Nunn 2003; Asian Pacific Society of Periodontology 2004). It has been demonstrated that not everybody is at equal risk to periodontal destruction, despite inadequate oral hygiene and hence exposure to microbial dental plaque, because of different combinations of risk factors (Löe et al 1978a,b). Currently, risk assessment for periodontitis remains subjective, empirical and variable from one clinician to another and from one patient to another (Lang et al., 2003; Page et al., 2002; Persson et al., 2003b). Utilization of periodontal risk assessment system over time would probably result in more standardized and appropriate periodontal treatment plan, effective periodontal therapy and long-term maintenance care. The Periodontal Risk Calculator (PRC) (Page et al., 2002; Page et al., 2003; Persson et al., 2003b) has been developed and tested in USA and the Periodontal Risk Assessment (PRA) (Lang et al., 2003) has been proposed for clinical application in Europe. As a country has data on risk associations for periodontal destruction in its own citizens, it would be prudent for periodontal researchers in that country to construct and test the validity of an appropriate risk assessment model for clinical use in that country (Corbet & Jin 2004). As there is no such risk assessment system in Hong Kong, the present study is therefore to develop and validate a periodontal risk assessment system, i.e. Periodontal Risk Spider-web (PRS). Aims To build up a practical periodontal risk assessment system for the assessment of periodontal conditions as well as prognosis and estimation of treatment responses in Chinese subjects with periodontal disease. Objectives - To build up a risk assessment system. i.e. the Periodontal Risk Spider-web (PRS). - To validate the relationship between the PRS assessment score and the severity of periodontal disease. - To explore the possible linkage between PRS score and periodontal treatment response. Hypotheses - The severity of periodontal diseases could be assessed by the multi-factorial Periodontal Risk Spider-web. - Periodontal treatment outcome could be estimated by the multi-factorial Periodontal Risk Spider-web.

 

Project Title:

Novel molecular mechanisms of innate host defense - implications in periodontal health and disease

Investigator(s):

Jin LJ

Department:

Dental Faculty

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

12/2005

 

Abstract:

To determine whether there is an association between subgingival bacterial colonization patterns (both beneficial and pathological species) and the expression of LBP,CD14, TLR-2, 4 and MD-2; to determine whether there is an association between bacterial infection patterns and the expression profiles of human α-defensins (hBD), as well as bactericidal/permeability-increasing protein (BPI); to assess whether there is an association between IL-1R/TLR mediated intracellular signaling pathways and bacterial infection patterns; to explore whether there is a potential association of the negative regulators of inflammatory signaling (e.g. P13K, IRAK-M, SOCS-1 and Tollip) with NF-χB mediated gene expression of cytokines, and clarify the molecular mechanisms involved in maintenance of periodontal homeostasis and pathogenesis of periodontal destruction.

 

Project Title:

Effects of periodontal treatment on serum levels of C-reactive protein and interleukin-6 in Chinese adults with chronic periodontitis

Investigator(s):

Jin LJ, Tse OD, Corbet EF

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

09/2006

 

Abstract:

Prevalence of periodontal diseases in Hong Kong Periodontal disease is one of the most common dental diseases in humans and it is also a major cause of tooth loss in adults after 40 years of age. A previous study on 372 35-44-yr-old and 537 non-institutionalized 65-74-yr-old Hong Kong Chinese showed that all subjects had one or more teeth with calculus, bleeding, or both, most teeth being so affected; and 15-17% of subjects had clinical signs of severe periodontitis. Of the older cohort, 16% were edentulous or indicated for extraction of all remaining teeth (Holmgren et al. 1994). Periodontal diseases and cardiovascular diseases: Is there a link? Chronic infections and inflammation play a major role in atherogenesis and cardiovascular disease (CVD) (Danesh et al. 1997; Loos 2005). Emerging evidence has suggested a significant moderate association between periodontal infection and CVD. Periodontitis being a chronic inflammatory and infectious disease, therefore has undergone substantial research to evaluate its relation with CVD. Approximately 42 relevant studies been published and most of them showed significant positive associations between these two diseases. Furthermore, both diseases appear to share a number of characteristics and factors in common, as they are more likely to occur in individuals who are older, male, smoker, with uncontrolled diabetics, stress, lower educational status, financial constraints, and social isolation (Offenbacher & Beck 2005). However, the association between periodontal disease and CVD has not yet been proved to be that of a causal relationship. The underlying biological mechanisms by which periodontal infection might affect the atherogenesis and contribute to CVD remain unclear. It is speculated that the inflamed and ulcerated pocket epithelium may form an easy port of entry for a number of Gram-negative and anaerobic bacteria in dental plaque biofilm. Bacteremia in periodontitis has been reported after oral examination, and periodontal pathogens have been identified in atheromatous plaques. Bacterial components, such as major outer membrane proteins and endotoxins (i.e. LPS), may be disseminated in blood as well. In response to the bacteremia and bacterial antigens that are systemically dispersed, blood cells as well as tissue cells at locations where the antigens are relocated may produce cytokines and pro-inflammatory mediators. Furthermore, the locally produced pro-inflammatory mediators in inflamed periodontal tissues, such as IL-1, TNF-α, IL-6, and PGE2, may be “dumped” into the circulation and exert systemic or distant effects. Periodontal disease has also been associated with increased carotid intima-medial wall thickness, a measure of subclinical atherosclerosis; and may independently contribute to the pathogenesis of atheroma formation. An alternative explanation for the association of periodontal diseases and CVD is that periodontal pathogens may exist in atherosclerotic lesions and actively invade human endothelial cells. Direct invasion of vessel walls by oral pathogens could trigger an inflammatory response that may translate into endothelial dysfunction. A recent study showed that periodontitis may be associated with the development of early atherosclerotic carotid lesions (Söder et al. 2005). CRP and IL-6 Systemic inflammation may represent an underlying mechanism that links periodontal disease with CVD. The potential role of periodontal disease as a possible chronic source of systemic infection and inflammation is supported by findings indicating an association of periodontal disease with elevated serum levels of CRP and IL-6 (Loos 2005). Plasma levels of CRP and IL-6 were consistently higher in periodontitis patients than in healthy controls (Loos et al. 2000). Currently, CRP and IL-6 serve as sensitive markers for evaluation of the inflammatory status of an individual (Ridkeret al. 1997; Danesh 2000). CRP has proved to be the strongest and most significant predictor of the risk of future cardiovascular events among several plasma variables. Slightly elevated (>0.3mg/l up to 3mg/l) and chronically present levels of CRP were determined to have predictive value for occurrence of a cardiovascular event (Rosenson & Koenig 2003; Ridker et al. 2004). A recent consensus conference of the American Heart Association and the Centre for Diseases Control focused on the clinical utility of markers of inflammation in the management of CVD risk. In addition to the classical risk estimation based on well-defined markers (e.g. smoking, obesity, hyperlipidaemia, hypertension, diabetes, age and gender), three risk categories according to serum CRP levels were identified: subjects with CRP concentration less than 1mg/l are considered to be at low risk, whereas those with concentrations in the 1-3mg/l range were assigned a medium risk, and those with concentrations more than 3mg/l are considered to be at high risk for future cardiovascular disease and events (Pearson et al. 2003). The effect of periodontal therapy Recent studies have shown that control of periodontal infection could reduce serum levels of CRP and IL-6 (Ready et al. 2004; Offenbacher & Beck 2005). These markers appear to be predictive and in some instance causally related to atherosclerosis, myocardial infarction, stroke, and thrombosis. Studies on serum levels of CRP and IL-6 may therefore contribute to further understanding of the association between periodontal infection and cardiovascular diseases, thrombotic events and atherosclerosis. Recent studies demonstrated that patients with severe periodontal disease exhibited endothelial dysfunction through assessment of flow-mediated dilation of brachial artery and CRP levels, and endothelial dysfunction could be reversible after successful periodontal treatment, with a significant reduction of CRP levels comparable to those in control group (Amar et al. 2003; Seinost et al. 2005). There is increasing evidence from clinical trials that the improvement of endothelial function may translate into lower rates of cardiovascular events (Bonetti et al. 2003). Aims of the study Currently, there are no similar studies on Chinese population. The present study therefore aims to investigate the effects of periodontal treatment on serum levels of selected acute-phase reactants in Chinese adults with chronic periodontitis. The objectives of the present study are i) to determine the association of serum levels of CRP and IL-6 with the severity of periodontal disease in Chinese adults with chronic periodontitis; ii) to investigate the effects of non-surgical periodontal treatment on the serum levels of CRP and IL-6; and iii) to study the association between changes in serum levels of CRP and IL-6 with treatment responses to non-surgical periodontal therapy.

 

List of Research Outputs

 

Carayol N., Chen J., Yang F., Jin T., Jin L.J., States D. and Wang C.-.Y., A dominant function of IKK/NF-kB signaling in global lipopolysaccharide-induced gene expression, Journal of Biological Chemistry. 2006, 281: 31142-31151.

 

Chan W.C., Ng C.H., Yiu B.K., Liu C.Y., Ip C.M., Siu H.H., Chiu G.K.C., Hagg E.U.O. and Jin L.J., A survey on the preference for continuing professional dental education amongst general dental practitioners who attended the 26th Asia Pacific Dental Congress, European Journal of Dental Education. 2006, 10: 210-216.

 

Chien A.Y.J., She T.T., Jin L.J., McGrath C.P.J. and Corbet E.F., Quality of life and orthodontic correction of incisor drifting, Journal of Dental Research. 2006, 85 (Spec Iss B): 420 (PEF).

 

Jayatilake J.A.M.S., Samaranayake L.P., Lu Q. and Jin L.J., IL-Ia, IL-Ira and IL-8 are differentially induced by Candida in experimental oral candidiasis, Oral Diseases. Blackwell Munksgaard, 2007, 13: 426-433.

 

Jin L.J., Editorial Board Member (overseas), Chinese Journal of Dental Research. 2006.

 

Jin L.J., Editorial Board Member, International Dental Journal. 2007.

 

Jin L.J., Editorial Board Member, Journal of Periodontal Research. 2006.

 

Jin L.J., Invited lecture, “An update on periodontal aetiopathogenesis and clinical implications”, College of Stomatology, Wuhan University, Wuhan, China, February 7. 2007.

 

Jin L.J., Invited lecture, “An update on periodontal etiopathogenesis”, Annual Meeting of Association for Dental Sciences of the Republic of China, Taipei, Taiwan, August 25-27. 2006.

 

Jin L.J., Invited lecture, “Clinical management of severe periodontitis patients”, Stomatological Hospital (Jian-Li) of Wuhan University, Dongguan, China, April 25. 2007.

 

Jin L.J., Invited lecture, “Clinical management of smokers with periodontal diseases”, 5th Annual Conference of the International Society for the Prevention of Tobacco Induced Diseases, November 24-26. 2006.

 

Jin L.J., Invited lecture, “Clinical management of subjects with advanced periodontitis”, 10th China International Exhibition & Symposium on Dental Equipment, Technology & Products, Shanghai, China, November 1-4. 2006.

 

Jin L.J., Invited lecture, “Diabetes and cardiovascular diseases in Asia, a review. (Symposium: Biofilms and inflammation: Important factors in oral health", FDI Annual World Dental Congress, September 22-25, Shenzhen, China. 2006.

 

Jin L.J., Invited lecture, “Periodontal Etiopathogenesis - Recent Advance and Perspectives”, Institute of Odontology, Karolinska Institute, Stockholm, Sweden, March 30. 2007.

 

Jin L.J., Invited lecture, “Periodontal infections and cardiovascular disease - Scientific evidence and clinical implications”, National Satellite Video-conference (8 cities) on a Symposium on Oral Health and Diabetes and Cardiovascular Diseases, Guangzhou, China, April 26. 2007.

 

Jin L.J., Invited lecture, “Research advance in periodontal etiopathogenesis and clinical implications”, Peking University School of Stomatology, Beijing, China, December 17. 2006.

 

Jin L.J., Member of Editorial Advisory Board, Journal of Periodontology. 2006.

 

Jin L.J., Modern life and oral hygiene (one of the contributors), Journal of Dental Prevention and Treatment. 2006, 14: 247-248.

 

Jin L.J., Shum I.H.Y., Leung P.C., Lau E., Kwok A. and Orwoll E.S., Periodontal conditions in Hong Kong Chinese men with osteoporosis/osteopenia, Journal of Dental Research. 2007, 86 (Spec Iss A): 645.

 

Jin L.J., Periodontic-orthodontic interactions - rationale, sequence and clinical implications, Hong Kong Dental Journal. 2007, 4: 60-64.

 

Jin L.J., Reviewer (ad hoc), Mycopathologia. 2007.

 

Jin L.J., Reviewer (ad hoc), Tissue Antigens. 2007.

 

Söder B., Jin L.J., Klinge B. and Söder P.~.$.D.6., Periodontitis and premature death: a 16-year longitudinal study in a Swedish urban population, Journal of Periodontal Research. 2007, 42: 361-366.

 

Researcher : Kam YL

List of Research Outputs

 

McMillan A.S., Tsang P.C.S., Wong M.C.M. and Kam Y.L., Efficacy of a novel lubricating system in the management of radiotherapy-related xerostomia, Oral Oncology. 2006, 42(8): 842-8.

 

Researcher : King NM

Project Title:

Aesthetic concerns of adolescents and young adults in relation to development defects of enamel

Investigator(s):

King NM, Lo ECM

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2002

 

Abstract:

To develop a set of standardized photographic images showing permanent anterior teeth with developmental enamel defects of different types suitable for investigating people's perception of the aesthetics; to determine the aesthetic perception and the need for treatment of adolescents and young adults in relation of different enamel defects in Chinese (Hong Kong); to evaluate the effect of gender, age, dental training (knowledge) and dental impairment on people's aesthetic perception of developmental enamel defects.

 

Project Title:

Permeability of dentin adhesives

Investigator(s):

King NM, Tay FRCM, Yiu CKY, Cheong CHL

Department:

Dental Faculty

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

10/2003

 

Abstract:

To evaluate the micro-tensile bond strength (muTBS) and permeability of different dentin bonding systems over time in water and in oil; to evaluate the ultra-structural morphology of the resin-dentin interfaces of different bonding systems over time in water and in oil using SEM and TEM; to determine the extent of silver nitrate penetration into four versions of resin blends with increasing degrees of hydrophilicity after long-term storage; to determine the ultimate tensile bond strength of the four resin blends in (3) after long-term storage; to advance basic science research in the improvement of the long-term durability of dentin bonding systems for the restoration of teeth.

 

Project Title:

Remineralization ability of hydroxyapatite containing dentifrices

Investigator(s):

King NM, Itthagarun A, Ng YW

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2003

 

Abstract:

To explore an in vitro pH cycling study of the progression of initial enamel caries lesion treated with commercially available dentifrices contain hydroxyapatite crystals.

 

Project Title:

The effects of different concentrations of water on the bonding efficacy to dentin of self-etching primers

Investigator(s):

King NM, Tay FRCM

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

 

Abstract:

To create experimental self-etching primers using one acidic resin monomer, one hydrophilic resin monomer, a fixed amount of ethanol and variable amounts of water for simultaneous etching and priming of dentin.

 

List of Research Outputs

 

Anthonappa R.P., Itthagarun A. and King N.M., Re-mineralization potential of a fluoride chewing gum versus fluoride dentifrice: preliminary results of an in-situ study, Hong Kong Dental Journal. 2007, 4(1): 28-35.

 

Chung C.W.M., Anthonappa R.P., Yiu C.K.Y. and King N.M., Concomitant occurrence of hypodontia and supernumerary teeth in two children , International Journal of Paediatric Dentistry. 2007, 17: P.69.

 

Dhanpal P.K., Anthonappa R.P., Yiu C.K.Y. and King N.M., Dens evaginatus and dens invaginatus in a single tooth, International Journal of Paediatric Dentistry. 2007, 17: P.70.

 

Hiraishi N., Yiu C.K.Y. and King N.M., Bonding strength on dentin from primary tooth with amelogenesis imperfecta, International Journal of Paediatric Dentistry. 2007, 17: P.17.

 

Itthagarun A., King N.M. and Yiu C.K.Y., Paediatric Dentistry in Hong Kong, Expressions (Newsletter of the HKU Faculty of Dentistry). 2007, Issue 1: 11.

 

King N.M., Wong H.M. and Kumar V.L.N., Doxycycline: Are its 'side-effects' a contra-indication to its use?, Hong Kong Journal of Paediatrics. 2007, 12(2): 105-110.

 

King N.M., Wong H.M., Almandaey A.H., Dhanpal P.K. and Ekambaram M., More Milk , stronger teeth. (Part III) , Dental Asia. 2007, March/April: 12-16.

 

King N.M., Wong H.M., Almandaey A.H., Dhanpal P.K. and Ekambaram M., More milk, stronger teeth? - Part 2, Dental Asia. 2006, November/December: 23-27.

 

King N.M. and Wong H.M., More milk, stronger teeth? - Part I, Dental Asia . 2006, July/August: 17-21.

 

King N.M., Anthonappa R.P. and Itthagarun A., The importance of the primary dentition to children - Part 1: consequences of not treating carious teeth., The Hong Kong Practitioner. 2007, 29: 52-61.

 

King N.M., Anthonappa R.P. and Itthagarun A., The importance of the primary dentition to children - Part 2: effects of treating carious teeth by extraction, The Hong Kong Practitioner. 2007, 29: 101-107.

 

Lee C.K., Lo E.C.M., King N.M. and Cho S.Y., Management of supernumerary tooth in association with talon cusp on the primary incisor., Hong Kong Dental Journal. 2006, 3 No.2: 117-122.

 

Lee C.K., King N.M., Lo E.C.M. and Cho S.Y., Talon cusp in the primary dentition: Literature review and report of three rare cases , Journal of Clinical Pediatric Dentistry. 2006, 30(4): 299- 305.

 

Lee C.K., King N.M., Lo E.C.M. and Cho S.Y., The relationship between a primary maxillary incisor with a talon cusp and the permanent successor: a study of 57 cases , International Journal of Paediatric Dentistry. 2007, 17: 178-185.

 

Manikandan E., Yiu C.K.Y. and King N.M., Double teeth with facial and lingual talon cusps, International Journal of Paediatric Dentistry . 2007, 17: P.69-70.

 

Peerzada F., Anthonappa R.P., Yiu C.K.Y. and King N.M., Congenitally missing first permanent molars: a case report, International Journal of Paediatric Dentistry . 2007, 17: P.69.

 

Rabie A.B.M., Wong R.W.K. and King N.M., Aesthetic Dentistry and Orthodontics, The Hong Kong Medical Diary. 2006, Vol. 11 No.8: 7-11.

 

Tongkoom S., Wong H.M., King N.M. and Cheong H.L., Prevalence and inter-relationship of dental anomalies and traits , International Journal of Paediatric Dentistry. 2007, 17 - Suppl.1: 164.

 

Wong H.-.M., McGrath C.P.J., Lo E.C.M. and King N.M., Association between developmental defects of enamel and different concentrations of fluoride in the puiblic water supply, Caries Research. 2006, 40: 481-486.

 

Wong H.-.M. and King N.M., More milk, stronger teeth? (Part I) , Dental Asia. 2006, July/August issue: 17-21.

 

Wong H.M., McGrath C.P.J. and King N.M., Dental practitioners' views on the need to treat developmental defects of enamel, Community Dentistry and Oral Epidemiology. 2007, 35: 130-139.

 

Yiu C.K.Y., Hiraishi N. and King N.M., Bond strength of self-etch adhesives to bur-cut dentin, International Journal of Paediatric Dentistry. 2007, 17: P.18.

 

Yiu C.K.Y., Hiraishi N. and King N.M., Effect of dentinal surface preparation on bond strength of self-etch adhesives, 20th Annual Scientific Meeting of the Faculty of Dentistry, Faculty of Dentistry, The Universlity of Hong Kong. 2006.

 

Yiu C.K.Y., King N.M. and Itthagarun A., Good beginnings, Expressions (Newsletter of the HKU Faculty of Dentistry). 2007, Issue 1: 11.

 

Researcher : Lee AMP

List of Research Outputs

 

Lee A.M.P., Minimal Intervention Dentistry, The Hong Kong Medical Diary . 2006, 11 No.8: 2.

 

Researcher : Lee CK

List of Research Outputs

 

Lee C.K., Lo E.C.M., King N.M. and Cho S.Y., Management of supernumerary tooth in association with talon cusp on the primary incisor., Hong Kong Dental Journal. 2006, 3 No.2: 117-122.

 

Lee C.K., Rabie A.B.M., Wong R.W.K. and McGrath C.P.J., Poster Presentations: Comparison of pain level in microimplant surgery versus other orthodontic procedures. , 20th Annual Scientific Meeting of the Faculty of Dentistry, The University of Hong Kong, 15 December 2006.. 2006.

 

Lee C.K., King N.M., Lo E.C.M. and Cho S.Y., Talon cusp in the primary dentition: Literature review and report of three rare cases , Journal of Clinical Pediatric Dentistry. 2006, 30(4): 299- 305.

 

Lee C.K., King N.M., Lo E.C.M. and Cho S.Y., The relationship between a primary maxillary incisor with a talon cusp and the permanent successor: a study of 57 cases , International Journal of Paediatric Dentistry. 2007, 17: 178-185.

 

Researcher : Lee DH

List of Research Outputs

 

Zee K.Y., Lee D.H. and Corbet E.F., Repeated oral hygiene instructions alone, or in combination with metronidazole dental gel with or without subgingival scaling in adult periodontitis patients: A one-year clinical study, Journal of the International Academy of Periodontology. 2006, 8: 125-135.

 

Researcher : Leung KCM

Project Title:

Oral yeast and anaerobic bacteria level in patients with Sjögren's syndrome after saliva stimulation

Investigator(s):

Leung KCM, McMillan AS, Leung WK

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

 

Abstract:

To quantify and compare the colonization of yeast and anaerobic bacteria in oral rinse, supra-gingival plaque and stimulated saliva harvested from SS patients before and after saliva stimulation by cevimeline; to obtain precise identification of oral yeast and lactobacillus; to compare the virulence of Candida albicans before and after saliva stimulation.

 

Project Title:

Salivary microbes in patients with Sjögren's syndrome

Investigator(s):

Leung KCM, Leung WK, McMillan AS

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

12/2005

 

Abstract:

Sjögren's syndrome (SS) is one of the most common auto-immune disorders which affects 3-4% of adults, middle-aged women in particular. Major pathological changes involve lymphocyte and plasma cell infiltration of the salivary, lacrimal and other exocrine glands with progressive destruction of gland acini. The major oral complication of SS is severe dryness of the mouth (xerostomia) resulting in a shift of the oral microbial equilibrium to become more cariogenic, ie. increased level of Lactobacillus and Streptococcus mutans. Thus, SS subjects have a higher susceptibility to dental caries and early tooth loss. Objectives: 1. to quantify the colonization of Streptococci and Lactobacilli in whole saliva of SS patients 2. to identify, characterize and speciate the Streptococci and Lactobacilli species 3. to study the association of the level of salivary Streptococci and Lactobacilli species in of SS patients with concurrent caries status

 

List of Research Outputs

 

Leung K.C.M., McMillan A.S. and Leung W.K., Cariogenic bacterial in southern Chinese people with Sjögen's syndrome, 20th Annual Scientific Meeting, Faculty of Dentistry, The University of Hong Kong. 2006, Abstract #P4: 27.

 

Leung K.C.M., Effect of cevimeline on oral health and quality of life in Sjogren's syndrome patients, PhD thesis. Hong Kong, 2007, 1-294.

 

Researcher : Leung VWH

Project Title:

Study of the calcium-phosphate system artificial oral environments

Investigator(s):

Leung VWH, Darvell BW

Department:

Dental Faculty

Source(s) of Funding:

Other Funding Scheme

Start Date:

01/1994

 

Abstract:

In parallel with the numerical modelling work for calcium-phosphate in human saliva, direct studies of the stabilities of the calcium phosphate systems in various aqueous ionic media re being undertaken to provide experimental tests of the theoretical predictions.

 

Project Title:

Solution ionic effects on the demineralisation of calcified hard tissue

Investigator(s):

Leung VWH

Department:

Dental Faculty

Source(s) of Funding:

Other Funding Scheme

Start Date:

01/1994

 

Abstract:

To study the aqueous solution ionic effects on the demineralisation rate of dental calcified hard tissue.

 

Project Title:

Further development of an artificial saliva

Investigator(s):

Leung VWH, Darvell BW

Department:

Dental Faculty

Source(s) of Funding:

Other Funding Scheme

Start Date:

01/1994

 

Abstract:

To further develop an artificial saliva for the laboratory testing of the performance of materials serving in the oral environment.

 

Project Title:

Numerical modelling of the calcium-phosphate system in human saliva

Investigator(s):

Leung VWH, Darvell BW

Department:

Dental Faculty

Source(s) of Funding:

Other Funding Scheme

Start Date:

01/1994

 

Abstract:

Use of RAMESES, software designed for the solution of multiple equilibrium equations, to model the chemistry of saliva with a view to understanding the solid / solution interactions of the calcium-phosphate system.

 

Project Title:

Legal aspects of dentsitry

Investigator(s):

Leung VWH

Department:

Dental Faculty

Source(s) of Funding:

Other Funding Scheme

Start Date:

07/2001

 

Abstract:

To study the legal implications on the practice of dentists and the handling of dental materials by the dental profession.

 

Researcher : Leung WK

Project Title:

A randomized clinical trial using Rofecoxib as an adjunct to promote periodontal healing in non-surgical mechanical therapy on smokers

Investigator(s):

Leung WK

Department:

Dental Faculty

Source(s) of Funding:

Other Funding Scheme

Start Date:

12/2003

 

Abstract:

To carry out randomized clinical trial using Rofecoxib as an adjunct to promote periodontal healing in non-surgical mechanical therapy on smokers.

 

Project Title:

Polymorphisms of interleukin-1 Gene in Chinese chronic periodontitis patients

Investigator(s):

Leung WK, Zee KY, Song Y

Department:

Dental Faculty

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

12/2004

Completion Date:

11/2006

 

Abstract:

The main objective of this project is focus on screening the IL-1 gene loci of Chinese periodontitis patients to identify haplotype tag single-nucleotide polymorphisms (SNPs), evaluation of linkage disequilibrium (LD), and association studies of the gene cluster with periodontitis.

 

Project Title:

Molecular detection of Actinobacillus actinomycetemcomitans: clarification it's role in periodontitis

Investigator(s):

Leung WK

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

10/2005

 

Abstract:

Hypothesis - PCR based Actinobacillus actinomycetemcomitans (Aa) detection is reliable; the currently available most popular detection method by Ashimoto (et al. 1996), however, need vigorous quality control and cross-reaction tests; - Aa prevalence in health, disease and periodontally treated condition are different and could be used in monitor of host’s periodontal health situation Objectives 1. to isolate and characterize bacterial strains from subgingival plaque of age- and sex-matched individuals with various periodontal health or diseased conditions using the Ashimoto PCR Aa detection protocol (Ashimoto et al. 1996); 2. to conduct complete 16S rDNA gene sequence analysis of all isolates identified; 3. Characterization, using cloning, sequencing and PCR techniques, from the subgingival plaque samples from the above mentioned subjects, the predominantly detectable complete 16S rDNA gene sequence which cross reacts with the Ashimoto PCR Aa detection primers; 4. taking data from objective 2 and 3 in consideration, to verify or identify the best 16S rDNA based PCR method to detect presence of Aa.

 

Project Title:

Polymorphisms of Fc Gamma receptor Genes in Chinese Chronic Periodontitis Patients

Investigator(s):

Leung WK, Song Y

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

09/2006

 

Abstract:

Background: Human periodontitis is an infectious disease characterized by chronic inflammatory destruction of tooth supporting tissues. The tissue destruction is the result of unfavourable interactions between periodonto-pathogenic bacteria and host immuno-inflammatory responses in susceptible individuals. This complex chronic disease process is characterized by involvement of multiple factors, biological pathways and multiple disease modifying genes in a variety of fashions leading to similar clinical phenomena/presentation, i.e. in the case of periodontitis, destruction of periodonotium supporting tooth. More and more evidence avaible indicated that increase periodontal disease risk is associated with genetic polymorphism of more than one gene. Previous investigations of this group in a "candidate gene experimental approach" revealed that possible association between homogeneous geneotypes of single-nucleotide polymorphisms (SNP) rs1801274 (structural gene) and genotype CC in rs13878 (promotor region) in Fc gamma receptor 2A (FCGR2A) gene is associated with periodontitis (Chai et al, 2006). The current proposal is an attempt to clarify and characterize this genetic association between FCG receptor genes and human periodontitis.Objective: This proposal focuses on FCG receptor genes loci of Chinese periodontitis patients to identify haplotype tag SNPs, evaluation of linkage disequilibrium (LD), and association studies of the gene cluster with periodontitis.Significance: Undesirable FCGR genotypes appeared to be one significant predisposing factor in human periodontitis. Understanding the extent to which variation in the gene determines inter-individual variation in FCGR mediated immune response may turn out to be useful for preventing suceptible individuals from getting the disease or clinical management of individuals already affected by periodontitis.

 

List of Research Outputs

 

Leung K.C.M., McMillan A.S. and Leung W.K., Cariogenic bacterial in southern Chinese people with Sjögen's syndrome, 20th Annual Scientific Meeting, Faculty of Dentistry, The University of Hong Kong. 2006, Abstract #P4: 27.

 

Leung W.K., Editor-in-Chief, Hong Kong Dental Journal. Hong Kong, Hong Kong Academy of Medicine Press, 2007.

 

Leung W.K., Panel discussion: Qualified dental profession through evidence based dentistry. "Enhancing Clinical Learning in a PBL curriculum", 17th Meeting of the South East Asian Association for Dental Education (SEAADE), Sept 13 - 16, Jakarta, Indonesia. 2006.

 

Leung W.K., Third-year remarks, Hong Kong Dental Journal. 2006, 3: 75.

 

McMillan A.S., Pow E.H.N., Kwong D.L.W., Wong M.C.M., Sham J.S.T., Leung L.H.T. and Leung W.K., Preservation of quality of life after intensity-modulated radiotherapy for early-stage nasopharyngeal carcinoma: Results of a prospective longitudinal study, Head & Neck. 2006, 28: 712-722.

 

Ng S.K.S. and Leung W.K., A community study on the relationship between stress, coping, affective dispositions and periodontal attachment loss, Community Dentistry and Oral Epidemiology. 2006, 34: 252-266.

 

Pow E.H.N., Leung W.K., McMillan A.S. and Kwong D.L.W., Oral yeast colonization in southern Chinese nasopharyngeal carcinoma survivors., 20th Annual Scientific Meeting, Faculty of Dentistry, The University of Hong Kong. 2006.

 

Pow E.H.N., Kwong D.L.W., McMillan A.S., Wong M.C.M., Sham J.S.T., Leung L.H.T. and Leung W.K., Xerostomia and quality of life after intensity-modulated radiotherapy vs. conventional radiotherapy for early-stage nasopharyngeal carcinoma: Initial report on a randomized control clinical trial., International Journal of Radiation Oncology, Biology, Physics. 2006, 66: 981-991.

 

Researcher : Li TKL

List of Research Outputs

 

Li T.K.L., New Development in Dental Radiology, Hong Kong Dental Association, monthly meeting. 2006.

 

Liang B.M.H., Li T.K.L., Lo E.C.M., Mok W.H. and Ma E.C.Y., Patterns of tooth loss in young Hong Kong adults: a preliminary study based on Prince Philip Dental Hospital patients in 1984, 1998 and 2004, Hong Kong Dental Journal. 2007, 4: 22-27.

 

MacDonald-Jankowski D.S., Li T.K.L. and Matthew I., Magnetic Resonance Imaging. Part 2: the Clinical Applications, Asian Journal of Oral Maxillofacial Surgery. 2006, 18: 236-248.

 

Researcher : Liang BMH

List of Research Outputs

 

Liang B.M.H., Chen Y.-.M., Wu X., Yip H.K. and Smales R.J., Fracture resistance of roots with thin walls restored using an intermediate resin compsite layer placed between the dentine and a cast metal post, European Journal of Prosthodontics. 2007, 15: 19-22.

 

Wu H.F., Luk K.C., Liang B.M.H., Chen Y.M., Yip H.K. and Smales R.J., Mathematical analysis of occlusal rest design for cast removable partial dentures , European Journalof Prosthodontics. 2007, 15: 29-32.

 

Researcher : Lin HC

List of Research Outputs

 

Lo E.C.M., Wong A.H.H., Chu C.H. and Lin H.C., ART restoration and silver fluoride treatment for decayed primary molars, Journal of Dental Research. 2007, 86 (Spec Iss A): 2772.

 

Researcher : Liu JKS

List of Research Outputs

 

Liu J.K.S., McGrath C.P.J., Cheung M.N.B., Choi K.C., Hui K.K., Lee C.C., Li C.H., Tam S.W.Y., Wung C.S.Y. and Yeung S.L., Tooth bleaching - knowledge and acceptance of Hong Kong Chinese, Community Health Project Report Series. Faculty of Dentistry, The University of Hong Kong, 2007, 150: 1-49.

 

Researcher : Lo ECM

Project Title:

A randomized clinical trial of two innovative methods in treating tooth decay in young children

Investigator(s):

Lo ECM, Chu CH

Department:

Dental Faculty

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

01/2005

 

Abstract:

To describe longitudinally the clinical outcomes of placing atraumatic restorative treatment (ART) restorations in decayed primary molars in young children; to describe longitudinally the clinical outcomes of treating decayed primary molars with annual topical applications of silver diamine fluoride (SDF) solution in young children; to compare the effectiveness of placing ART restorations with that of SDF solution applications on arresting the progression of dental caries in young children.

 

Project Title:

A comparative study on the cost-effectiveness of four methods in preventing fissure caries in permanent teeth

Investigator(s):

Lo ECM, Chu CH

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

01/2007

 

Abstract:

The aim of this proposed study is to investigate the cost-effectiveness of four methods in preventing fissure caries in permanent teeth in primary school children in China. The four caries prevention methods are: resin fissure sealant, atraumatic restorative treatment (ART) sealant, sodium fluoride varnish, and silver diamine fluoride (SDF) solution. The specific study objectives are: 1. to describe longitudinally the clinical outcomes of using the above four methods to prevent dental caries in the pits and fissures of permanent first molars in school children, 2. to describe the cost of using the above four methods to prevent dental caries in an outreaching dental care programme in China, and 3. to compare the cost-effectiveness of the above four caries prevention methods.

 

List of Research Outputs

 

Chu C.H. and Lo E.C.M., A review of sodium fluoride varnish, General Dentistry. 2006, July-August: 247-253.

 

Lee C.K., Lo E.C.M., King N.M. and Cho S.Y., Management of supernumerary tooth in association with talon cusp on the primary incisor., Hong Kong Dental Journal. 2006, 3 No.2: 117-122.

 

Lee C.K., King N.M., Lo E.C.M. and Cho S.Y., Talon cusp in the primary dentition: Literature review and report of three rare cases , Journal of Clinical Pediatric Dentistry. 2006, 30(4): 299- 305.

 

Lee C.K., King N.M., Lo E.C.M. and Cho S.Y., The relationship between a primary maxillary incisor with a talon cusp and the permanent successor: a study of 57 cases , International Journal of Paediatric Dentistry. 2007, 17: 178-185.

 

Liang B.M.H., Li T.K.L., Lo E.C.M., Mok W.H. and Ma E.C.Y., Patterns of tooth loss in young Hong Kong adults: a preliminary study based on Prince Philip Dental Hospital patients in 1984, 1998 and 2004, Hong Kong Dental Journal. 2007, 4: 22-27.

 

Lo E.C.M., Wong A.H.H., Chu C.H. and Lin H.C., ART restoration and silver fluoride treatment for decayed primary molars, Journal of Dental Research. 2007, 86 (Spec Iss A): 2772.

 

Lo E.C.M., Luo Y., Tan H., Dyson J.E. and Corbet E.F., Art and conventional root restorations in elders after 12 months, Journal of Dental Research. 2006, 85: 929-932.

 

Lo E.C.M., Lui K.C., Chan C.Y., Chan M.T., Chen L.C., Chiu K.Y., Ho C.K., Lam H.N., Lam W.F. and Wai D.T.S., Oral health care for the physically handicapped, Community Health Project Report Series. Faculty of Dentistry, The University of Hong Kong, 2007, 146: 1-38.

 

Luo Y., Lo E.C.M., Tan H., Dyson J.E. and Corbet E.F., ART and conventional root restorations in elders after 3 years, Journal of Dental Research. 2007, 86 (Spec Iss A): 2435.

 

Wong H.-.M., McGrath C.P.J., Lo E.C.M. and King N.M., Association between developmental defects of enamel and different concentrations of fluoride in the puiblic water supply, Caries Research. 2006, 40: 481-486.

 

Wong M.C.M., Lam K.F. and Lo E.C.M., Faculty Research Output Prize, 2006.

 

Researcher : Lo J

Project Title:

3 dimensional hard and soft tissue assessment of maxillofacial deformity in Hong Kong Chinese population

Investigator(s):

Lo J, Wong MCM

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

12/2005

 

Abstract:

Objectives 1. To acquire the 3-D facial norm value in Hong Kong Chinese Population. 2. To develop a 3-D soft & hard tissue assessment scheme for patient presented with maxillofacial deformity. Backgrounds Facial profile could be regarded as one of the most important concern of every single person. Maxillofacial deformities, which would distort upper & lower jaws’ relationship and facial profile, are reported to affect approximately 20% of the world’s population. Tremendous advances in the treatment of these deformities have been made since 1970s. Orthognathic surgery, specially designed for the correction of these deformities, is currently one of the most common practices in the field of oral & maxillofacial surgery. The success of the orthognathic surgery depends not only on the surgical techniques, but also upon an accurate pre-surgical plan. The traditional approach to a maxillofacial deformity involves clinical examination, plain X-rays, dental model surgery and videoimaging surgical simulation. Among them, the videoimaging surgical simulation could be regarded as one of the most important component. Apart from assisting surgeon to make an accurate treatment plan, this technique also tremendously helps the communication between surgeons and patients. In a study, 6-month after surgery in a non-imaged population, only 45% of patients reported satisfaction with the aesthetic outcome of their orthognathic surgery, whereas 89% of patients reported satisfaction with their aesthetic outcome after using videoimaging simulation in the same period. Outline of problem Despite the continuous evolution of technology, the traditional approach had several limitations: (1) The dental model surgery involves only correction of the occlusion only, while the correction of some additional skeletal deformity, including chin, mandibular border, gonial angle, paranasal, malar, and zygoma region, would rely mainly on intra-operative judgement. (2) Current videoimaging softwares share the similar limitation: the prediction is only limited in lateral profile only. Prediction of the frontal profile, based on the plain radiographs, is nearly impossible due to overlapping of the hard and soft tissue landmarks. Benefits of videoimaging technique are hence limited to cases presented with deformity in lateral profile / sagittal plane; while patients presented with problem in frontal / coronal plane could not gain any benefits from this technique. As a result, correction of any deformity in frontal plane, i.e. facial asymmetry, is depending solely on the model surgery and intra-operative judgment; and those patients are in lack any visualization of the change after operation. With the rapid increasing in quantity and quality, the worldwide Oral Health Care System becomes much more sophisticated. Patients’ demand on good quality treatment is increasing as well. The previous standard established since late 1980s, could no longer meet today patient’s expectation. Due to the complexity of the facial skeleton, current trend in surgical planning is moving from 2-dimension to 3-dimension. Past research in this field The use of 3D cephalometric analysis had been reported since 1996. Thereafter, a number of reports had been published. All 3D cephalometric analysis is based on measurement on CT scan. It is noteworthy that all the reports are consistent with the advantages in direct visualization of the hard tissue problem especially in patients presented with asymmetry. Regarding the soft tissue analysis, 3D soft tissue capture technique had been developed since 1996. The techniques included: morphanalysis, laser scanning, 3D CT, stereolithography, 3D ultrasonography, 3D facial morphometry, digigraph imaging, Moire topography, and contour photography. Recently, the use of stereophotogrammetry had gained popularity due to its fast capture speed as well as the photo-realistic quality. The application of stereophotogrammetry in studying asymmetry had been widely studied. Nevertheless, there was no literature regarding the combination of 3D hard and soft tissue capture, analysis and surgical planning. Situation in Hong Kong & Chinese Population The discipline of Oral and Maxillofacial Surgery, the University of Hong Kong, is the largest maxillofacial center in Hong Kong, and one of the most advanced maxillofacial center in Asia and the world. From 1990 to 2004, there were about 4530 patients received major operations from our discipline. Among them, 1455 patients (32.12%) received orthognathic surgeries for correction of their maxillofacial deformity. Majority of patients (60%) were presented with Class III deformity, while approximately 23 % patients were presented with deformity in frontal / coronal plane. Currently, assessment of the changes of facial skeleton could be achieved through plain radiograph and lateral portrait using our CASSOS system (Softenable, Hong Kong). Since every single patient would like to know what he or she is going to look like after surgery, 3D facial analysis, planning and surgical simulation system of patients with maxillofacial deformity seems to be necessary to solve the shortcoming of the traditional 2D facial analysis. Specific Aims 1. To acquire the 3-D facial value in Hong Kong Chinese Population. All the current soft tissue change indices available are based on studies of single jaw surgery in Caucasian using lateral portrait only since early 1990s (Bell et al, 1992). Nowadays, bimaxillary osteotomies are more common. And relative to Caucasian, Chinese population have obvious difference in both hard and soft tissue profile, namely, the mandibular length, cranial base, and gonial angle, etc (Ngan et al. 1997). It is noteworthy that current available cephalometric and soft tissue norm data available for Chinese / Asian are based on cephalometric and lateral portrait only. To develop a new application to produce a realistic surgical simulation and prediction, a 3D norm hard and soft tissue data seems necessary. Result from this study could also be employed for comparison to the previous golden standard from 1994 (Farkas et al., 1994). 2. To develop a 3-D soft & hard tissue assessment and planning scheme for maxillofacial deformity Based on the norm data obtained from the specific aim (1), a further insight in the variation of patients with maxillofacial deformity from normal subjects could be obtained. By measurement of the postoperative 3D data, an estimation of the 3D soft tissue – hard tissue movement ratio of Chinese population could be established.

 

List of Research Outputs

 

Cheung L.K. and Lo J., The long-term effect of transport distraction in the management of temporomandibular joint ankylosis, Plast Reconstr Surg. 2007, 119(3): 1003-9.

 

Lo J. and Cheung L.K., Bimaxillary distraction in hemifacial microsomia: a retrospective study of 6 patients, Abstract of XVIII Congress of the European Association for Cranio-Maxillofacial Surgery, 12 - 15 September. 2006, Abstract No. 0-262.

 

Lo J. and Cheung L.K., Bimaxillary distraction in hemifacial microsomia: a retrospective study of 6 patients, Journal of Cranio-Maxillofacial Surgery. 2006, 34 (Suppl. S1): p. 99.

 

Lo J. and Cheung L.K., Craniofacial Fibrous Dysplasia, Asia Hospital & Center Annual Symposium on Oral & Maxillofacial Surgery, Manila, Plippines. 2007.

 

Lo J. and Cheung L.K., Distraction Osteogenesis for the craniomaxillofacial region. Part 2: a compendium of devices for the mandible, Asian J Oral Maxillofac Surg. 2007, 19: p. 6-18.

 

Lo J. and Cheung L.K., Endoscopic assisted rigid fixation in intra-oral vertical subsigmoid osteotomy: a preliminary study, Abstracts of XVIII Congress of the European Association for Journal of Cranio-Maxillofacial Surgery. 2006, 34 Suppl. S1: p.77 Abstract No 0.276.

 

Lo J. and Cheung L.K., Endoscopic-assisted rigid fixation in intra-oral vertical subsigmoid osteotomy: a preliminary clinical study, Surgical Practice . 2006, 10 (Suppl): p. A6.

 

Lo J. and Cheung L.K., Endoscopic-assisted rigid fixation of condylar fracture: a technical note, Journal of Oral and Maxillofacial Surgery. 2006, 64: 1443-1446.

 

Lo J. and Cheung L.K., Management of facial asymmetry, 2007 Orthognathic Surgery Symposium, Manila, Philippines . 2007.

 

Researcher : Low DCY

List of Research Outputs

 

Chan A.W.K., Low D.C.Y., Cheung G.S.P. and Ng R.P.Y., A questionnaire survey of endodontic practice profile among dentists in Hong Kong, Hong Kong Dental Journal. 2006, 3: 80-87.

 

Cheung L.H.M., Low D.C.Y. and Cheung G.S.P., Root morphology - A study of the mandibular second molar of ethnic Chinese, Ann Roy Australas Coll Dent Surg. 2006, 18: 47-50.

 

Low D.C.Y., A lecture on root canal treatment, Joint HKU/Eastman Dental Institute CE Course at Peking University, Beijing, PRC. 2006.

 

Low D.C.Y., Experiences Of Teaching Undergraduate Student With ProTaper FHU Instruments., Dentsply Asia.. 2007.

 

Low D.C.Y., Retreatment Options – Removal Of Separated Instruments., Joint HKU/Eastman Dental Institute CE Course at Peking University, Beijing, PRC. . 2006.

 

Researcher : Lu Q

List of Research Outputs

 

Jayatilake J.A.M.S., Samaranayake L.P., Lu Q. and Jin L.J., IL-Ia, IL-Ira and IL-8 are differentially induced by Candida in experimental oral candidiasis, Oral Diseases. Blackwell Munksgaard, 2007, 13: 426-433.

 

Researcher : Lui KC

List of Research Outputs

 

Lo E.C.M., Lui K.C., Chan C.Y., Chan M.T., Chen L.C., Chiu K.Y., Ho C.K., Lam H.N., Lam W.F. and Wai D.T.S., Oral health care for the physically handicapped, Community Health Project Report Series. Faculty of Dentistry, The University of Hong Kong, 2007, 146: 1-38.

 

Researcher : Luk KC

List of Research Outputs

 

Wu H.F., Luk K.C., Liang B.M.H., Chen Y.M., Yip H.K. and Smales R.J., Mathematical analysis of occlusal rest design for cast removable partial dentures , European Journalof Prosthodontics. 2007, 15: 29-32.

 

Researcher : Luk WK

List of Research Outputs

 

Luk W.K., Technical Aspects on dental erosion cases, Faculty of Dentistry, the University of Hong Kong. 2007.

 

Researcher : Luo Y

Project Title:

Clinical efficacy of two topical fluoride agents for treatment of dentinal hypersensitivity

Investigator(s):

Luo Y, Lo ECM

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

01/2006

 

Abstract:

Dentinal hypersensitivity, also known as tooth sensitivity, can be described as a short sharp pain triggered by a stimulus such as cold or hot foods/beverages, sweet, sour, or acidic foods and even brushing and flossing. It may occur when the enamel is worn away or more frequently, when the gums recede and the cementum on root surface is worn away leaving the underlying dentine exposed. Both incorrect oral hygiene techniques by patients and by instrumentation of the root surface by dental professionals in the management of periodontal diseases can lead to the symptoms of dentine hypersensitivity. A variety of agents have been suggested for treatment of dentine hypersensitivity, including the use of potassium nitrate, strontium chloride, sodium fluoride, silver nitrate and calcium hydroxide. These agents generally work by blocking the dentinal tubules resulting in diminishing the movement of fluid in the tubules e.g., the hydrodynamic theory or the primary mechanism for dentine hypersensitivity. However, evidence from well-conducted clinical trials to support the claimed effectiveness of these agents is scanty. The purpose of this study is to evaluate the effectiveness of two topical fluoride agents, a 38% silver diammine fluoride solution and a 5% sodium fluoride varnish, in reducing dentinal hypersensitivity after non-surgical periodontal treatment. The objectives of the study are: 1. to describe the effectiveness of a single application of a 38% silver diammine fluoride solution in reducing dentinal hypersensitivity in teeth that are sensitive to external stimuli after non-surgical periodontal treatment; 2. to describe the effectiveness of a single application of a 5% sodium fluoride varnish in reducing dentinal hypersensitivity in teeth that are sensitive to external stimuli after non-surgical periodontal treatment; and 3. to compare the effectiveness of the above two topical fluoride agents in reducing dentinal hypersensitivity in teeth that are sensitive to external stimuli after non-surgical periodontal treatment.

 

List of Research Outputs

 

Du M.Q., Luo Y., Zeng X.J., Alkhatib N. and Bedi R., Caries in preschool children and its risk factors in 2 provinces in China, Quintessence International. 2007, 38: 143-151.

 

Lo E.C.M., Luo Y., Tan H., Dyson J.E. and Corbet E.F., Art and conventional root restorations in elders after 12 months, Journal of Dental Research. 2006, 85: 929-932.

 

Luo Y., Lo E.C.M., Tan H., Dyson J.E. and Corbet E.F., ART and conventional root restorations in elders after 3 years, Journal of Dental Research. 2007, 86 (Spec Iss A): 2435.

 

Luo Y. and McGrath C.P.J., Oral health status of homeless people in Hong Kong, Special Care in Dentistry . 2006, 26: 150-154.

 

Luo Y., McMillan A.S., Wong M.C.M., Zheng J. and Lam C.L.K., Orofacial pain conditions and impact on quality of life in community-dwelling elderly people in Hong Kong, Journal of Orofacial Pain. 2007, 21: 63-71.

 

Researcher : Ma L

List of Research Outputs

 

Cheung L.K., Zheng L. and Ma L., Effect of distraction rates on expression of bone morphogenetic proteins in rabbit mandibular distraction osteogenesis, Journal of Cranio-maxillofacial Surgery. 2006, 34: 263-9.

 

Cheung L.K., Ma L. and Zheng L., Tissue engineering for mandibular bone lengthening in smokers. , Europen Cell and Materials . 2007, 13: 9.

 

Cheung L.K., Ma L. and Zheng L., Tissue engineering for mandibular bone lengthening in smokers, International Biotechnology Symposium on "From Basic Research to Clinical Applications using Biotechnology and Bioengineering". 2006, p.36.

 

Ma L. and Cheung L.K., Effect of nicotine on bone healing in mandibular distraction osteogenesis, 20th Annual Scientific Meeting, Faculty of Dentistry, The University of hong Kong. 2006, p. 23.

 

Ma L. and Cheung L.K., Effect of nicotine on bone healing in mandibular distraction osteogenesis, Asian J Oral Maxillofac Surg. 2006, 18:3 (suppl 1): p. 47.

 

Ma L., Zheng L. and Cheung L.K., Effect of nicotine on bone regeneration in mandibular distractin osteogenesis, Transactions of 3rd Asia Pacific Congress on Craniofacial Surgery & Distraction Osteogenesis. 2007, p. 259-271.

 

Ma L., Zheng L. and Cheung L.K., Inhibitory effect of nicotine on bone regeneration in mandibular distraction osteogenesis, Frontiers in Bioscience. 2007, 12: 3256-62.

 

Zheng L., Ma L. and Cheung L.K., Effect of nicotine on expression of bone morphogenetic protein-2 in rabbit mandibular distraction osteogenesis, 4th Tissue Engineering Symposium. 2007, p. 64.

 

Zheng L., Ma L. and Cheung L.K., Effect of nicotine on mandibular distraction osteogenesis: a radiological and immunohistochemical study, Europen Cell and Materials. 2007, 13: 54.

 

Zheng L., Ma L. and Cheung L.K., Effect of nicotine on mandibular distraction osteogenesis: a radiological and immunohistochemical study, International Biotechnology Symposium on "From Basic Research to Clinical Applications using Biotechnology and Bioengineering". 2006, Poster 04.

 

Zheng L., Ma L. and Cheung L.K., Effect of recombinant human tissue inhibitor of matrix metalloproteinase-1 in rabbit mandibular distraction osteogenesis: a histological and immunohistochemical study, Journal of Cranio-maxillofacial Surgery. 2006, 34: 277-82.

 

Researcher : McGrath CPJ

Project Title:

'Bucked teeth' (severe incisor overjet), orthodontic corrective treatment and the life quality of children in China: a multi-centre cohort study

Investigator(s):

McGrath CPJ, Hagg EUO

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2003

 

Abstract:

To assess the impact of severe incisor overjet on the life quality of children in China; to measure changes in the impact of oral health on the quality of life of children who undergo corrective orthodontic treatment of severe incisor overjet; to assess the correlation between changes in the magnitude of oral health related quality of life following orthodontic treatment and the improvements in alignment of teeth observed clinically.

 

List of Research Outputs

 

Broder H.L., McGrath C.P.J. and Cisneros G.J., Questionnaire development: face validity and item impact testing of the Child Oral Health Impact Profile, Community Dentistry and Oral Epidemiology. 2007, 35 (Suppl 1): 8-19.

 

Chien A.Y.J., She T.T., Jin L.J., McGrath C.P.J. and Corbet E.F., Quality of life and orthodontic correction of incisor drifting, Journal of Dental Research. 2006, 85 (Spec Iss B): 420 (PEF).

 

Lee C.K., Rabie A.B.M., Wong R.W.K. and McGrath C.P.J., Poster Presentations: Comparison of pain level in microimplant surgery versus other orthodontic procedures. , 20th Annual Scientific Meeting of the Faculty of Dentistry, The University of Hong Kong, 15 December 2006.. 2006.

 

Lee S., McGrath C.P.J. and Samman N., Quality of life in patients with dentofacial deformity: a comparison of measurement approaches, International Journal of Oral and Maxillofacial Surgery. 2007, 36: 488-492.

 

Lee S.H.E.R.M.I.N., McGrath C.P.J. and Samman N., Quality of life of patients with dentofacial deformity, Asian Journal of Oral and Maxillofacial Surgery. 2006, 18, No. 3 (suppl 1): p. 45-46.

 

Lee T.C., Rabie A.B.M., Wong R.W.K. and McGrath C.P.J., Patients perception to microimplant as anchorage in orthodontics , 83rd Congress of the European Orthodontic Society, Berlin, Germany, 20-24 June. 2007.

 

Lee T.C.K., Rabie A.B.M., Wong R.W.K. and McGrath C.P.J., Patients’ Perception To Micro-implant as Anchorage in Orhodontics, The Second Cross-Strait Four Regions Orthodontic Conference, Nanjing, China, 19 – 21 November, 2006. . 2006.

 

Liu J.K.S., McGrath C.P.J., Cheung M.N.B., Choi K.C., Hui K.K., Lee C.C., Li C.H., Tam S.W.Y., Wung C.S.Y. and Yeung S.L., Tooth bleaching - knowledge and acceptance of Hong Kong Chinese, Community Health Project Report Series. Faculty of Dentistry, The University of Hong Kong, 2007, 150: 1-49.

 

Luo Y. and McGrath C.P.J., Oral health status of homeless people in Hong Kong, Special Care in Dentistry . 2006, 26: 150-154.

 

McGrath C.P.J., McMillan A.S. and Zhu H., Agreement between patient and proxy of life quality after stroke, Journal of Dental Research. 2007, 86 (Spec Iss A): 101.

 

McGrath C.P.J. and Newsome P.R.H., Patient-Centred Measures in Dental Practice: 2. Qualify of Life, Dental Update. 2007, 34: 41-44.

 

McGrath C.P.J., Chong M.M., Chow T.F., Huang K.Y., Lam K.H.H., Lo H.H.Y., Tse C.M., Wong R.S.Y. and Yu K.Y., Pregnancy and oral health: A study among pregnant women in Hong Kong, Community Health Project Report Series. Faculty of Dentistry, The University of Hong Kong, 2007, 151: 1-53.

 

McGrath C.P.J., Sham A.S.K., Ho D.K.L. and Wong J.H.L., The impact of dental neglect on oral health: a population based study in Hong Kong, International Dental Journal. 2007, 57: 3-8.

 

Mok C.W., Zhou L., McGrath C.P.J., Hagg E.U.O. and Bendeus S.A.M., Agreement between study casts and their images in assessing of malocclusion and treatment need. , The Second Cross-Strait Four Regions Orthodontic Conference, Nanjing, China. 18-21 November, 2006.

 

Mok C.W., Zhou L., McGrath C.P.J., Hagg E.U.O. and Bendeus S.A.M., Poster Presentation: Agreement between study casts and their images in assessing of malocclusion and treatment need. , 20th Annual Scientific Meeting of the Faculty of Dentistry. 15th December, 2006; The Prince Philip Dental Hospital.. 2006.

 

Newsome P.R.H. and McGrath C.P.J., Patient-Centred Measures in Dental Practice: 3. Patient Satisfaction, Dental Update. 2007, 34: 87-90.

 

Newsome P.R.H. and McGrath C.P.J., Patient-Centred Measures in Dental Practice: Part 1. An overview, Dental Update. 2006, 33: 596-600.

 

Whelton H., Crowley E., O'Mullane D., McGrath C.P.J., Woods N., Kelleher V., Byrtek M. and Guiney H., Oral Health of Irish Adults 2000 - 2002, 2007, 1-248.

 

Wong A.H.H., Cheung C.S. and McGrath C.P.J., Developing a short form of Oral Health Impact Profile (OHIP) for dental aesthetics: OHIP-aesthetic, Community Dentistry and Oral Epidemiology. 2007, 35: 64-72.

 

Wong A.T.Y., McMillan A.S. and McGrath C.P.J., Oral health-related quality of life and severe hypodontia, Journal of Oral Rehabilitation. 2006, 33: 869-873.

 

Wong H.-.M., McGrath C.P.J., Lo E.C.M. and King N.M., Association between developmental defects of enamel and different concentrations of fluoride in the puiblic water supply, Caries Research. 2006, 40: 481-486.

 

Wong H.M., McGrath C.P.J. and King N.M., Dental practitioners' views on the need to treat developmental defects of enamel, Community Dentistry and Oral Epidemiology. 2007, 35: 130-139.

 

Zhang M., McGrath C.P.J. and Hagg E.U.O., Patients' expectations and experiences of fixed orthodontic appliance therapy, Angle Orthodontist. 2007, 77: 318-322.

 

Zhang M., McGrath C.P.J. and Hagg E.U.O., The impact of malocclusion and its treatment on quality of life: a literature review, International Journal of Paediatric Dentistry. 2006, 16: 381-387.

 

Zhang M., McGrath C.P.J. and Hagg E.U.O., Who knows more about the impact of malocclusion on children's quality of life, mothers or fathers?, European Journal of Orthodontics. 2007, 29: 180-185.

 

Zhou L., Mok C.W., Hagg E.U.O., McGrath C.P.J. and Bendeus S.A.M., Poster Presentation: Dentofacial characteristics among Hong Kong Chinese children in different occlusion catergories., The Second Cross-Strait Four Regions Orthodontic Conference, Nanjing, China. 18-21 November, 2006. . 2006.

 

Zhou L., Mok C.W., Hagg E.U.O., McGrath C.P.J. and Bendeus S.A.M., Poster Presentation: Sagittal dental arch relationship versus anteroposterior skeletal pattern among 12-years-old Hong Kong Chinese Children., 20th Annual Scientific Meeting of the Faculty of Dentistry. 15th December, 2006; The Prince Philip Dental Hospital.. 2006.

 

Researcher : McMillan AS

Project Title:

Oral health related quality of life after stroke: a longitudinal study of patient and proxy outcomes

Investigator(s):

McMillan AS, Wong MCM

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

Completion Date:

07/2006

 

Abstract:

To measure teh oral health-related quality of life (OQoL) of stroke survivors during the acute phase of stroke, on discharge from hospital and 6 months later and compare with a matched comparison group; to measure and compare the OQoL of stoke survivors at the three stages; to assess and compare the agreement on OQoL between stroke survivors and proxies at the three stages; to measure the oral health-related functional disability of stroke survivors at the three stages and compare with a matched comparison group; to assess the association between oral health-related functional disability and OQoL in stroke survivors; to assess the oral health status of stroke survivors at the three stages and compare with matched controls; to assess possible assocations between oral health factors and health-related quality of life.

 

Project Title:

Orofacial Pain and its Functional and Psychosocial Impact

Investigator(s):

McMillan AS, Wong MCM, Lam CLK, Luo Y

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2005

 

Abstract:

This is a cross-disciplinary study involving the Faculties of Dentistry and Medicine that is directly related to the major research theme of Healthy Ageing.Hypotheses:o A substantial number of community-dwelling adults in Hong Kong suffer from orofacial pain (OFP) and the majority of them do not seek professional help for their condition o OFP is an under-treated condition that causes significant disability and has a serious adverse effects on people's well-being and quality of life.Purpose: To investigate a) the prevalence of OFP and its diagnostic sub-groups in community dwelling adult people in Hong Kong, b) the adverse impact of OFP on functional and psychosocial wellbeing, and c) barriers to treatment seeking for OFP symptoms.Objectives:o To determine the frequency, severity and pattern of OFP according to diagnostic sub-groups using validated patient-centred measures and clinical assessmento To describe the treatment seeking behaviour associated with OFP and factors associated with such behaviouro To assess the impact of OFP on health-related QoL using generic and condition specific health status measureso To correlate patient descriptions of OFP with clinical diagnosesPain is closely associated with poor health. The negative effect of pain on health outcomes such as function and quality of life (QoL) among patient populations is well documented (Ahmedzai, 1995). However, little is known about the impact of pain on subjective health and well-being in community dwelling populations (Reyes-Gibby et al, 2002).Although pain is a common symptom of dental and oral disease and can have a significant impact, there is a shortage of systematic data on the prevalence, severity and consequences of orofacial pain (OFP) in general, non-clinical populations (Nikias, 1985). In a community based study in Toronto, Locker & Grushka (1987) noted that 53% of participants had experienced some pain or discomfort in the orofacial region in the previous four weeks. The majority of pain reports were tooth or gum related whereas pain in the jaws, face and oral mucosa were less common.Epidemiological studies in the USA, Canada and the United Kingdom have shown that the prevalence of oro-facial pain symptoms in adult populations ranges from 14 to 40% (Lipton et al, 1993; Locker & Grushka, 1987; Macfarlane et al 2002). Gender and age-related differences in oro-facial pain prevalence have also been noted with women and younger adults at apparently greater risk of pain symptoms, whereas older people are more likely to suffer more severe pain (Macfarlane et al, 2002; Von Korff et al, 1988). Pain may have considerable impact on people's ability to perform effectively at work, home and school. Nonetheless, not everyone seeks professional help for pain with some symptoms being ignored while others may prompt action (Macfarlane et al, 2003). It is, therefore, important to discern factors that may distinguish individuals who seek professional care from those who do not. In a population-based study of OFP in the UK, Macfarlane et al (2003) noted that less than half of their study population with OFP sought professional advice. The majority of factors associated with seeking treatment appeared to be various characteristics of pain although the time course of these factors was unclear. Locker & Grushka (1987) observed that while more than 50% of their OFP study group described pain severity as moderately severe or severe, only 40 % of those reporting pain sought advice from a doctor of dentist. Ethnic differences in the perception of and means of managing pain account, at least in part, for observed differences in treatment seeking behaviour for orofacial pain conditions (Hastie et al, 2005). Socioeconomic status is also an important factor related to treatment seeking with oral disease generally more common among those least able to access health care and leads to needless pain and suffering (Riley et al, 2005).There is presently very little information on the prevalence and impact of oro-facial pain in Southern Chinese people in Hong Kong. Most oro-facial pain prevalence studies have focused on predominantly Caucasian populations. However, a recent study in Korean elders indicated that the prevalence was higher in this ethnic group and significant disability was associated with the condition (Chung et al, 2004). In a previous population-based survey, we have shown that self-reported pain symptoms associated with temporomandibular disorders are relatively common in the Hong Kong Chinese population (Pow et al, 2001). However, the characteristics of the pain differed from other ethnic groups, no gender bias in pain symptoms was observed and treatment seeking was much lower than in Caucasian counterparts. One of the problems associated with the available epidemiological data on prevalence of OFP is that it has been collected solely by means of questionnaires with patient self-reports not being confirmed by clinical assessment (Macfarlane et al, 2004). There is, therefore, the risk that patient described pain symptoms are misinterpreted and pain symptoms due to multiple conditions may go unrecognized. Definitive diagnoses can only be obtained by clinical assessment.References:Ahmedzai S. Recent clinical trials of pain control: impact on quality of life. Eur J Cancer 1995;31A(Suppl):S2-7Chung JW, Kim JH, Kim HD, Kho HS, Kim YK, Chung SC. Chronic orofacial pain among Korean elders: prevalence, and impact using the graded chronic pain scale. Pain 2004;112:164-170Hastie BA, Riley III JL, Fillingim RB. Ethnic differences and responses to pain in healthy young adults. Pain Medicine 2005;6:61-71Lipton JA, Ship JA, Larach-Robinson D. Estimated prevalence and distribution of reported orofacial pain in the United Sates. J Am Dent Assoc 1993;124:115-121Locker D, Grushka M. Prevalence of oral and facial pain and discomfort: preliminary results from a mail survey. Community Dent Oral Epidemiol 1987;15:169-172Macfarlane TV, Blinkhorn AS, Davies RM, Kincey J, Worthington HV. Factors associated with health care seeking behaviour for orofacial pain in the general population. Community Dent Health 2003;20:20-26Macfarlane TV, Blinkhorn AS, Craven R et al. Can one predict the likely specific orofacial pain syndrome from a self-completed questionnaire? Pain 2004;111:270-277Nikias M. Oral disease and the quality of life. Am J Public Health 1985;75:11-12Reyes-Gibby C, Aday L, Cleeland C. Impact of pain on self-related health in community-dwelling older adults. Pain 2002;95:75-82Riley III JL, Gilbert GH. Orofacial pain symptoms: an interaction between age and sex. Pain 2001;90:245-256Von Korff M, Ormel J, Keefe FJ, Dworkin SF. Grading the severity of chronic pain complaints. Pain 1988;32:173-183

 

Project Title:

Predictors of outcome of orofacial pain: A community-based longitudinal study

Investigator(s):

McMillan AS, Wong MCM, Lam CLK, Luo Y, Zheng J

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2006

 

Abstract:

This is a cross-disciplinary study involving the Faculties of Dentistry and Medicine that is directly related to the major research theme of Healthy Ageing.Purpose: To investigate a) the pain characteristics in community-dwelling adult Hong Kong Chinese people with OFP, b) to follow-up OFP sufferers over a 6-month period and identify presenting factors and behaviours that predict poor outcome. Null hypotheses:- Orofacial pain does not tend to persist - There are no factors that can predict the persistence of OFPObjectives:o To describe the outcome of OFP after a period of 6-monthso To identify baseline factors that predict poor outcome in adults with OFPOrofacial pain (OFP) may be defined as pain related to the face and/or mouth and involves both hard and soft tissues in these anatomical regions. Epidemiological studies in the USA, Canada and the United Kingdom have shown that the prevalence of OFP symptoms in adult populations ranges from 14 to 40%.1-3 In a population-based survey of OFP symptoms in adult Chinese people in Hong Kong, the one-month period prevalence of OFP (42%) was found to be consistent with estimates in western countries.4 Pain is closely associated with poor health and may considerably impair people's ability to perform daily living activities. Despite this, not all pain sufferers seek professional help with some symptoms being ignored whilst others prompt attention. (2,3,5,6). In studies involving western cohorts 44-46% with OFP sought professional help (2,5,6). However, only 20% of Hong Kong Chinese adults with OFP symptoms sought professional treatment.4 Thus, it is important to explore the factors and barriers relating to professional treatment seeking behaviour in order to understand the disparity between Chinese adults and their western counterparts. MacFarlane et al5 noted that pain characteristics appeared to prompt treatment seeking although the time course of these factors was unclear. The decision to seek treatment may be related to the consequences of the OFP as experienced by the individual and also affected by culturally-mediated responses to the pain experience and its consequences (7). A key characteristic of OFP is that it tends to persist (8). In a longitudinal study in the United Kingdom, over half those with OFP at baseline reported pain four years later (9). Persistent pain was associated with females, increasing age, psychological distress, widespread body pain and taking pain medication at baseline. In a Swedish cohort, the follow-up of 109 patients with OFP revealed that after 4 to 9 years only 27% had resolution of the pain, with pain medication usage at baseline a strong predictor of persistent OFP (10). The consequences of OFP have an impact on various aspects of daily life and include work loss, sleep disturbance, need for more rest, avoidance of social contacts, and difficulty eating and speaking (2,11). The magnitude of the impact appears to be related to the pain characteristics and socio-demographics of the respondents (2,3,11). Pain-related sleep disturbance is also a key determinant of seeking professional treatment (6). There is scant information available on the characteristics of OFP in southern Chinese people, its potential to persist and the functional and psychosocial impact. In a population-based survey of symptoms of temporomandibular disorders in Hong Kong Chinese people, jaw pain, restricted jaw opening and jaw clicking were the most common presenting symptoms and often associated with significant morbidity (12). In contradistinction to western studies, there were no gender-related differences in symptom reporting or treatment seeking (12). In a recent study of chronic OFP in elderly Koreans the prevalence appeared to be higher compared with Caucasian populations.13Adverse impacts were common with around 30% of those with joint pain, toothache and burning mouth symptoms having significant associated disability and impairment of daily living activities (13). The ideal approach to the investigation of OFP in the community is by interview using validated questionnaires and clinical assessment. However, most studies where patient-based and clinical data are available involve a bias sample of people seeking treatment. In epidemiological studies of OFP, the most common means of obtaining information is by questionnaire, by mail or telephone survey, without clinical examination of the participants. Even with contemporary questionnaire approaches, without clinical assessment, there is always the issue of data reliability. References 1. Lipton JA, Ship JA, Larach-Robinson D. Estimated prevalence and distribution of reported orofacial pain in the United States. J Am Dent Assoc 1993;124:115-21.2. Locker D, Grushka M. Prevalence of oral and facial pain and discomfort: preliminary results of a mail survey. Community Dent Oral Epidemiol 1987a;15:169-72.3. Macfarlane TV, Blinkhorn AS, Davies RM, Kincey J, Worthington HV (2002). Oro-facial pain in the community: prevalence and associated impact. Community Dent Oral Epidemiol 30(1):52-60.4. McMillan AS, Wong MCM, Zheng J, Lam CLK. Prevalence of orofacial pain and treatment seeking in Hong Kong Chinese. J Orofac Pain (in press) 5. Macfarlane TV, Blinkhorn AS, Davies RM, Kincey J, Worthington HV. Factors associated with health care seeking behaviour for orofacial pain in the general population. Community Dent Health 2003;20:20-26.6. Locker D. The symptom iceberg in dentistry. Treatment-seeking in relation to oral and facial pain. J Can Dent Assoc 1988:54:271-4.7. Hastie BA, Riley JL, Fillingim RB. Ethnic differences and responses to pain in healthy young adults. Pain Med 2005;6:61-71.8.Von Korff M, Ormel J, Keefe F, Dworkin S (1992). Grading the severity of chronic pain. Pain 50(2):133-149.9.Macfarlane TV, Blinkhorn AS, Davies RM, Kincey J, Worthington HV. Predictors of outcome for orofacial pain in the general population: a four-year follow-up study. 2004 J Dent Res ;83:712-7.10. Wolf E, Nilner M, Petersson A, Petersson K (2002). Long-term follow-up by means of a questionnaire of 109 patients with long-lasting orofacial pain. Swed Dent J. 26(3):125-34.11. Locker D, Grushka M. The impact of dental and facial pain. J Dent Res 1987;66:1414-7.12. Pow EHN, Leung KCM, McMillan AS. Prevalence of symptoms associated with temporomandibular disorders in Hong Kong Chinese. J Orofac Pain 2001;15:228-34.13. Chung JW, Kim JH, Kim HD, Kho HS, Kim YK, Chung SC. Chronic orofacial pain among Korean elders: prevalence, and impact using the graded chronic pain scale. Pain 2004;112:164-70.

 

List of Research Outputs

 

Lee P.W.H., Kwan T.T., Kwong D.L., Sham J.S., Pow E.H.N., McMillan A.S. and Au G.K., A prospective study of the impact of nasopharyngeal cancer and radiotherapy on the psychosocial condition of Chinese patients., Cancer. 2007, 109: 1344-54.

 

Leung K.C.M., McMillan A.S. and Leung W.K., Cariogenic bacterial in southern Chinese people with Sjögen's syndrome, 20th Annual Scientific Meeting, Faculty of Dentistry, The University of Hong Kong. 2006, Abstract #P4: 27.

 

Luo Y., McMillan A.S., Wong M.C.M., Zheng J. and Lam C.L.K., Orofacial pain conditions and impact on quality of life in community-dwelling elderly people in Hong Kong, Journal of Orofacial Pain. 2007, 21: 63-71.

 

McGrath C.P.J., McMillan A.S. and Zhu H., Agreement between patient and proxy of life quality after stroke, Journal of Dental Research. 2007, 86 (Spec Iss A): 101.

 

McMillan A.S., Leung W.S. and Wong M.C.M., Chronic orofacial pain in southern Chinese people: Prevalence, associated disability and help-seeking behaviour, Society of Oral Physiology. 2007, 25: 30.

 

McMillan A.S., Tsang P.C.S., Wong M.C.M. and Kam Y.L., Efficacy of a novel lubricating system in the management of radiotherapy-related xerostomia, Oral Oncology. 2006, 42(8): 842-8.

 

McMillan A.S., Pow E.H.N., Kwong D.L.W., Wong M.C.M., Sham J.S.T., Leung L.H.T. and Leung W.K., Preservation of quality of life after intensity-modulated radiotherapy for early-stage nasopharyngeal carcinoma: Results of a prospective longitudinal study, Head & Neck. 2006, 28: 712-722.

 

McMillan A.S., Wong M.C.M., Zheng J. and Lam C.L.K., Prevalence of Orofacial Pain and Treatment Seeking in Hong Kong Chinese, Journal of Orofacial Pain. 2006, 20: 218-225.

 

Pow E.H.N., Leung W.K., McMillan A.S. and Kwong D.L.W., Oral yeast colonization in southern Chinese nasopharyngeal carcinoma survivors., 20th Annual Scientific Meeting, Faculty of Dentistry, The University of Hong Kong. 2006.

 

Pow E.H.N., Kwong D.L.W., McMillan A.S., Wong M.C.M., Sham J.S.T., Leung L.H.T. and Leung W.K., Xerostomia and quality of life after intensity-modulated radiotherapy vs. conventional radiotherapy for early-stage nasopharyngeal carcinoma: Initial report on a randomized control clinical trial., International Journal of Radiation Oncology, Biology, Physics. 2006, 66: 981-991.

 

Tsang P.C.S., Ng H. and McMillan A.S., Antifungal susceptibility of Candida albicans biofilms on titanium discs with different surface roughness, Clinical Oral Investigations. 2007, Epub ahead of print.

 

Tsang P.C.S., Ng H. and McMillan A.S., SEM study of candidal-biofilms on titanium with different surface roughness, 84th General Session & Exhibition of the IADR 2006.. 2006.

 

Wong A.T.Y., McMillan A.S. and McGrath C.P.J., Oral health-related quality of life and severe hypodontia, Journal of Oral Rehabilitation. 2006, 33: 869-873.

 

Researcher : Mcgrath CPJ

Project Title:

'Bucked teeth' (severe incisor overjet), orthodontic corrective treatment and the life quality of children in China: a multi-centre cohort study

Investigator(s):

McGrath CPJ, Hagg EUO

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2003

 

Abstract:

To assess the impact of severe incisor overjet on the life quality of children in China; to measure changes in the impact of oral health on the quality of life of children who undergo corrective orthodontic treatment of severe incisor overjet; to assess the correlation between changes in the magnitude of oral health related quality of life following orthodontic treatment and the improvements in alignment of teeth observed clinically.

 

List of Research Outputs

 

Broder H.L., McGrath C.P.J. and Cisneros G.J., Questionnaire development: face validity and item impact testing of the Child Oral Health Impact Profile, Community Dentistry and Oral Epidemiology. 2007, 35 (Suppl 1): 8-19.

 

Chien A.Y.J., She T.T., Jin L.J., McGrath C.P.J. and Corbet E.F., Quality of life and orthodontic correction of incisor drifting, Journal of Dental Research. 2006, 85 (Spec Iss B): 420 (PEF).

 

Lee C.K., Rabie A.B.M., Wong R.W.K. and McGrath C.P.J., Poster Presentations: Comparison of pain level in microimplant surgery versus other orthodontic procedures. , 20th Annual Scientific Meeting of the Faculty of Dentistry, The University of Hong Kong, 15 December 2006.. 2006.

 

Lee S., McGrath C.P.J. and Samman N., Quality of life in patients with dentofacial deformity: a comparison of measurement approaches, International Journal of Oral and Maxillofacial Surgery. 2007, 36: 488-492.

 

Lee S.H.E.R.M.I.N., McGrath C.P.J. and Samman N., Quality of life of patients with dentofacial deformity, Asian Journal of Oral and Maxillofacial Surgery. 2006, 18, No. 3 (suppl 1): p. 45-46.

 

Lee T.C., Rabie A.B.M., Wong R.W.K. and McGrath C.P.J., Patients perception to microimplant as anchorage in orthodontics , 83rd Congress of the European Orthodontic Society, Berlin, Germany, 20-24 June. 2007.

 

Lee T.C.K., Rabie A.B.M., Wong R.W.K. and McGrath C.P.J., Patients’ Perception To Micro-implant as Anchorage in Orhodontics, The Second Cross-Strait Four Regions Orthodontic Conference, Nanjing, China, 19 – 21 November, 2006. . 2006.

 

Liu J.K.S., McGrath C.P.J., Cheung M.N.B., Choi K.C., Hui K.K., Lee C.C., Li C.H., Tam S.W.Y., Wung C.S.Y. and Yeung S.L., Tooth bleaching - knowledge and acceptance of Hong Kong Chinese, Community Health Project Report Series. Faculty of Dentistry, The University of Hong Kong, 2007, 150: 1-49.

 

Luo Y. and McGrath C.P.J., Oral health status of homeless people in Hong Kong, Special Care in Dentistry . 2006, 26: 150-154.

 

McGrath C.P.J., McMillan A.S. and Zhu H., Agreement between patient and proxy of life quality after stroke, Journal of Dental Research. 2007, 86 (Spec Iss A): 101.

 

McGrath C.P.J. and Newsome P.R.H., Patient-Centred Measures in Dental Practice: 2. Qualify of Life, Dental Update. 2007, 34: 41-44.

 

McGrath C.P.J., Chong M.M., Chow T.F., Huang K.Y., Lam K.H.H., Lo H.H.Y., Tse C.M., Wong R.S.Y. and Yu K.Y., Pregnancy and oral health: A study among pregnant women in Hong Kong, Community Health Project Report Series. Faculty of Dentistry, The University of Hong Kong, 2007, 151: 1-53.

 

McGrath C.P.J., Sham A.S.K., Ho D.K.L. and Wong J.H.L., The impact of dental neglect on oral health: a population based study in Hong Kong, International Dental Journal. 2007, 57: 3-8.

 

Mok C.W., Zhou L., McGrath C.P.J., Hagg E.U.O. and Bendeus S.A.M., Agreement between study casts and their images in assessing of malocclusion and treatment need. , The Second Cross-Strait Four Regions Orthodontic Conference, Nanjing, China. 18-21 November, 2006.

 

Mok C.W., Zhou L., McGrath C.P.J., Hagg E.U.O. and Bendeus S.A.M., Poster Presentation: Agreement between study casts and their images in assessing of malocclusion and treatment need. , 20th Annual Scientific Meeting of the Faculty of Dentistry. 15th December, 2006; The Prince Philip Dental Hospital.. 2006.

 

Newsome P.R.H. and McGrath C.P.J., Patient-Centred Measures in Dental Practice: 3. Patient Satisfaction, Dental Update. 2007, 34: 87-90.

 

Newsome P.R.H. and McGrath C.P.J., Patient-Centred Measures in Dental Practice: Part 1. An overview, Dental Update. 2006, 33: 596-600.

 

Whelton H., Crowley E., O'Mullane D., McGrath C.P.J., Woods N., Kelleher V., Byrtek M. and Guiney H., Oral Health of Irish Adults 2000 - 2002, 2007, 1-248.

 

Wong A.H.H., Cheung C.S. and McGrath C.P.J., Developing a short form of Oral Health Impact Profile (OHIP) for dental aesthetics: OHIP-aesthetic, Community Dentistry and Oral Epidemiology. 2007, 35: 64-72.

 

Wong A.T.Y., McMillan A.S. and McGrath C.P.J., Oral health-related quality of life and severe hypodontia, Journal of Oral Rehabilitation. 2006, 33: 869-873.

 

Wong H.-.M., McGrath C.P.J., Lo E.C.M. and King N.M., Association between developmental defects of enamel and different concentrations of fluoride in the puiblic water supply, Caries Research. 2006, 40: 481-486.

 

Wong H.M., McGrath C.P.J. and King N.M., Dental practitioners' views on the need to treat developmental defects of enamel, Community Dentistry and Oral Epidemiology. 2007, 35: 130-139.

 

Zhang M., McGrath C.P.J. and Hagg E.U.O., Patients' expectations and experiences of fixed orthodontic appliance therapy, Angle Orthodontist. 2007, 77: 318-322.

 

Zhang M., McGrath C.P.J. and Hagg E.U.O., The impact of malocclusion and its treatment on quality of life: a literature review, International Journal of Paediatric Dentistry. 2006, 16: 381-387.

 

Zhang M., McGrath C.P.J. and Hagg E.U.O., Who knows more about the impact of malocclusion on children's quality of life, mothers or fathers?, European Journal of Orthodontics. 2007, 29: 180-185.

 

Zhou L., Mok C.W., Hagg E.U.O., McGrath C.P.J. and Bendeus S.A.M., Poster Presentation: Dentofacial characteristics among Hong Kong Chinese children in different occlusion catergories., The Second Cross-Strait Four Regions Orthodontic Conference, Nanjing, China. 18-21 November, 2006. . 2006.

 

Zhou L., Mok C.W., Hagg E.U.O., McGrath C.P.J. and Bendeus S.A.M., Poster Presentation: Sagittal dental arch relationship versus anteroposterior skeletal pattern among 12-years-old Hong Kong Chinese Children., 20th Annual Scientific Meeting of the Faculty of Dentistry. 15th December, 2006; The Prince Philip Dental Hospital.. 2006.

 

Researcher : Mcmillan AS

Project Title:

Oral health related quality of life after stroke: a longitudinal study of patient and proxy outcomes

Investigator(s):

McMillan AS, Wong MCM

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

Completion Date:

07/2006

 

Abstract:

To measure teh oral health-related quality of life (OQoL) of stroke survivors during the acute phase of stroke, on discharge from hospital and 6 months later and compare with a matched comparison group; to measure and compare the OQoL of stoke survivors at the three stages; to assess and compare the agreement on OQoL between stroke survivors and proxies at the three stages; to measure the oral health-related functional disability of stroke survivors at the three stages and compare with a matched comparison group; to assess the association between oral health-related functional disability and OQoL in stroke survivors; to assess the oral health status of stroke survivors at the three stages and compare with matched controls; to assess possible assocations between oral health factors and health-related quality of life.

 

Project Title:

Orofacial Pain and its Functional and Psychosocial Impact

Investigator(s):

McMillan AS, Wong MCM, Lam CLK, Luo Y

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2005

 

Abstract:

This is a cross-disciplinary study involving the Faculties of Dentistry and Medicine that is directly related to the major research theme of Healthy Ageing.Hypotheses:o A substantial number of community-dwelling adults in Hong Kong suffer from orofacial pain (OFP) and the majority of them do not seek professional help for their condition o OFP is an under-treated condition that causes significant disability and has a serious adverse effects on people's well-being and quality of life.Purpose: To investigate a) the prevalence of OFP and its diagnostic sub-groups in community dwelling adult people in Hong Kong, b) the adverse impact of OFP on functional and psychosocial wellbeing, and c) barriers to treatment seeking for OFP symptoms.Objectives:o To determine the frequency, severity and pattern of OFP according to diagnostic sub-groups using validated patient-centred measures and clinical assessmento To describe the treatment seeking behaviour associated with OFP and factors associated with such behaviouro To assess the impact of OFP on health-related QoL using generic and condition specific health status measureso To correlate patient descriptions of OFP with clinical diagnosesPain is closely associated with poor health. The negative effect of pain on health outcomes such as function and quality of life (QoL) among patient populations is well documented (Ahmedzai, 1995). However, little is known about the impact of pain on subjective health and well-being in community dwelling populations (Reyes-Gibby et al, 2002).Although pain is a common symptom of dental and oral disease and can have a significant impact, there is a shortage of systematic data on the prevalence, severity and consequences of orofacial pain (OFP) in general, non-clinical populations (Nikias, 1985). In a community based study in Toronto, Locker & Grushka (1987) noted that 53% of participants had experienced some pain or discomfort in the orofacial region in the previous four weeks. The majority of pain reports were tooth or gum related whereas pain in the jaws, face and oral mucosa were less common.Epidemiological studies in the USA, Canada and the United Kingdom have shown that the prevalence of oro-facial pain symptoms in adult populations ranges from 14 to 40% (Lipton et al, 1993; Locker & Grushka, 1987; Macfarlane et al 2002). Gender and age-related differences in oro-facial pain prevalence have also been noted with women and younger adults at apparently greater risk of pain symptoms, whereas older people are more likely to suffer more severe pain (Macfarlane et al, 2002; Von Korff et al, 1988). Pain may have considerable impact on people's ability to perform effectively at work, home and school. Nonetheless, not everyone seeks professional help for pain with some symptoms being ignored while others may prompt action (Macfarlane et al, 2003). It is, therefore, important to discern factors that may distinguish individuals who seek professional care from those who do not. In a population-based study of OFP in the UK, Macfarlane et al (2003) noted that less than half of their study population with OFP sought professional advice. The majority of factors associated with seeking treatment appeared to be various characteristics of pain although the time course of these factors was unclear. Locker & Grushka (1987) observed that while more than 50% of their OFP study group described pain severity as moderately severe or severe, only 40 % of those reporting pain sought advice from a doctor of dentist. Ethnic differences in the perception of and means of managing pain account, at least in part, for observed differences in treatment seeking behaviour for orofacial pain conditions (Hastie et al, 2005). Socioeconomic status is also an important factor related to treatment seeking with oral disease generally more common among those least able to access health care and leads to needless pain and suffering (Riley et al, 2005).There is presently very little information on the prevalence and impact of oro-facial pain in Southern Chinese people in Hong Kong. Most oro-facial pain prevalence studies have focused on predominantly Caucasian populations. However, a recent study in Korean elders indicated that the prevalence was higher in this ethnic group and significant disability was associated with the condition (Chung et al, 2004). In a previous population-based survey, we have shown that self-reported pain symptoms associated with temporomandibular disorders are relatively common in the Hong Kong Chinese population (Pow et al, 2001). However, the characteristics of the pain differed from other ethnic groups, no gender bias in pain symptoms was observed and treatment seeking was much lower than in Caucasian counterparts. One of the problems associated with the available epidemiological data on prevalence of OFP is that it has been collected solely by means of questionnaires with patient self-reports not being confirmed by clinical assessment (Macfarlane et al, 2004). There is, therefore, the risk that patient described pain symptoms are misinterpreted and pain symptoms due to multiple conditions may go unrecognized. Definitive diagnoses can only be obtained by clinical assessment.References:Ahmedzai S. Recent clinical trials of pain control: impact on quality of life. Eur J Cancer 1995;31A(Suppl):S2-7Chung JW, Kim JH, Kim HD, Kho HS, Kim YK, Chung SC. Chronic orofacial pain among Korean elders: prevalence, and impact using the graded chronic pain scale. Pain 2004;112:164-170Hastie BA, Riley III JL, Fillingim RB. Ethnic differences and responses to pain in healthy young adults. Pain Medicine 2005;6:61-71Lipton JA, Ship JA, Larach-Robinson D. Estimated prevalence and distribution of reported orofacial pain in the United Sates. J Am Dent Assoc 1993;124:115-121Locker D, Grushka M. Prevalence of oral and facial pain and discomfort: preliminary results from a mail survey. Community Dent Oral Epidemiol 1987;15:169-172Macfarlane TV, Blinkhorn AS, Davies RM, Kincey J, Worthington HV. Factors associated with health care seeking behaviour for orofacial pain in the general population. Community Dent Health 2003;20:20-26Macfarlane TV, Blinkhorn AS, Craven R et al. Can one predict the likely specific orofacial pain syndrome from a self-completed questionnaire? Pain 2004;111:270-277Nikias M. Oral disease and the quality of life. Am J Public Health 1985;75:11-12Reyes-Gibby C, Aday L, Cleeland C. Impact of pain on self-related health in community-dwelling older adults. Pain 2002;95:75-82Riley III JL, Gilbert GH. Orofacial pain symptoms: an interaction between age and sex. Pain 2001;90:245-256Von Korff M, Ormel J, Keefe FJ, Dworkin SF. Grading the severity of chronic pain complaints. Pain 1988;32:173-183

 

Project Title:

Predictors of outcome of orofacial pain: A community-based longitudinal study

Investigator(s):

McMillan AS, Wong MCM, Lam CLK, Luo Y, Zheng J

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2006

 

Abstract:

This is a cross-disciplinary study involving the Faculties of Dentistry and Medicine that is directly related to the major research theme of Healthy Ageing.Purpose: To investigate a) the pain characteristics in community-dwelling adult Hong Kong Chinese people with OFP, b) to follow-up OFP sufferers over a 6-month period and identify presenting factors and behaviours that predict poor outcome. Null hypotheses:- Orofacial pain does not tend to persist - There are no factors that can predict the persistence of OFPObjectives:o To describe the outcome of OFP after a period of 6-monthso To identify baseline factors that predict poor outcome in adults with OFPOrofacial pain (OFP) may be defined as pain related to the face and/or mouth and involves both hard and soft tissues in these anatomical regions. Epidemiological studies in the USA, Canada and the United Kingdom have shown that the prevalence of OFP symptoms in adult populations ranges from 14 to 40%.1-3 In a population-based survey of OFP symptoms in adult Chinese people in Hong Kong, the one-month period prevalence of OFP (42%) was found to be consistent with estimates in western countries.4 Pain is closely associated with poor health and may considerably impair people's ability to perform daily living activities. Despite this, not all pain sufferers seek professional help with some symptoms being ignored whilst others prompt attention. (2,3,5,6). In studies involving western cohorts 44-46% with OFP sought professional help (2,5,6). However, only 20% of Hong Kong Chinese adults with OFP symptoms sought professional treatment.4 Thus, it is important to explore the factors and barriers relating to professional treatment seeking behaviour in order to understand the disparity between Chinese adults and their western counterparts. MacFarlane et al5 noted that pain characteristics appeared to prompt treatment seeking although the time course of these factors was unclear. The decision to seek treatment may be related to the consequences of the OFP as experienced by the individual and also affected by culturally-mediated responses to the pain experience and its consequences (7). A key characteristic of OFP is that it tends to persist (8). In a longitudinal study in the United Kingdom, over half those with OFP at baseline reported pain four years later (9). Persistent pain was associated with females, increasing age, psychological distress, widespread body pain and taking pain medication at baseline. In a Swedish cohort, the follow-up of 109 patients with OFP revealed that after 4 to 9 years only 27% had resolution of the pain, with pain medication usage at baseline a strong predictor of persistent OFP (10). The consequences of OFP have an impact on various aspects of daily life and include work loss, sleep disturbance, need for more rest, avoidance of social contacts, and difficulty eating and speaking (2,11). The magnitude of the impact appears to be related to the pain characteristics and socio-demographics of the respondents (2,3,11). Pain-related sleep disturbance is also a key determinant of seeking professional treatment (6). There is scant information available on the characteristics of OFP in southern Chinese people, its potential to persist and the functional and psychosocial impact. In a population-based survey of symptoms of temporomandibular disorders in Hong Kong Chinese people, jaw pain, restricted jaw opening and jaw clicking were the most common presenting symptoms and often associated with significant morbidity (12). In contradistinction to western studies, there were no gender-related differences in symptom reporting or treatment seeking (12). In a recent study of chronic OFP in elderly Koreans the prevalence appeared to be higher compared with Caucasian populations.13Adverse impacts were common with around 30% of those with joint pain, toothache and burning mouth symptoms having significant associated disability and impairment of daily living activities (13). The ideal approach to the investigation of OFP in the community is by interview using validated questionnaires and clinical assessment. However, most studies where patient-based and clinical data are available involve a bias sample of people seeking treatment. In epidemiological studies of OFP, the most common means of obtaining information is by questionnaire, by mail or telephone survey, without clinical examination of the participants. Even with contemporary questionnaire approaches, without clinical assessment, there is always the issue of data reliability. References 1. Lipton JA, Ship JA, Larach-Robinson D. Estimated prevalence and distribution of reported orofacial pain in the United States. J Am Dent Assoc 1993;124:115-21.2. Locker D, Grushka M. Prevalence of oral and facial pain and discomfort: preliminary results of a mail survey. Community Dent Oral Epidemiol 1987a;15:169-72.3. Macfarlane TV, Blinkhorn AS, Davies RM, Kincey J, Worthington HV (2002). Oro-facial pain in the community: prevalence and associated impact. Community Dent Oral Epidemiol 30(1):52-60.4. McMillan AS, Wong MCM, Zheng J, Lam CLK. Prevalence of orofacial pain and treatment seeking in Hong Kong Chinese. J Orofac Pain (in press) 5. Macfarlane TV, Blinkhorn AS, Davies RM, Kincey J, Worthington HV. Factors associated with health care seeking behaviour for orofacial pain in the general population. Community Dent Health 2003;20:20-26.6. Locker D. The symptom iceberg in dentistry. Treatment-seeking in relation to oral and facial pain. J Can Dent Assoc 1988:54:271-4.7. Hastie BA, Riley JL, Fillingim RB. Ethnic differences and responses to pain in healthy young adults. Pain Med 2005;6:61-71.8.Von Korff M, Ormel J, Keefe F, Dworkin S (1992). Grading the severity of chronic pain. Pain 50(2):133-149.9.Macfarlane TV, Blinkhorn AS, Davies RM, Kincey J, Worthington HV. Predictors of outcome for orofacial pain in the general population: a four-year follow-up study. 2004 J Dent Res ;83:712-7.10. Wolf E, Nilner M, Petersson A, Petersson K (2002). Long-term follow-up by means of a questionnaire of 109 patients with long-lasting orofacial pain. Swed Dent J. 26(3):125-34.11. Locker D, Grushka M. The impact of dental and facial pain. J Dent Res 1987;66:1414-7.12. Pow EHN, Leung KCM, McMillan AS. Prevalence of symptoms associated with temporomandibular disorders in Hong Kong Chinese. J Orofac Pain 2001;15:228-34.13. Chung JW, Kim JH, Kim HD, Kho HS, Kim YK, Chung SC. Chronic orofacial pain among Korean elders: prevalence, and impact using the graded chronic pain scale. Pain 2004;112:164-70.

 

List of Research Outputs

 

Lee P.W.H., Kwan T.T., Kwong D.L., Sham J.S., Pow E.H.N., McMillan A.S. and Au G.K., A prospective study of the impact of nasopharyngeal cancer and radiotherapy on the psychosocial condition of Chinese patients., Cancer. 2007, 109: 1344-54.

 

Leung K.C.M., McMillan A.S. and Leung W.K., Cariogenic bacterial in southern Chinese people with Sjögen's syndrome, 20th Annual Scientific Meeting, Faculty of Dentistry, The University of Hong Kong. 2006, Abstract #P4: 27.

 

Luo Y., McMillan A.S., Wong M.C.M., Zheng J. and Lam C.L.K., Orofacial pain conditions and impact on quality of life in community-dwelling elderly people in Hong Kong, Journal of Orofacial Pain. 2007, 21: 63-71.

 

McGrath C.P.J., McMillan A.S. and Zhu H., Agreement between patient and proxy of life quality after stroke, Journal of Dental Research. 2007, 86 (Spec Iss A): 101.

 

McMillan A.S., Leung W.S. and Wong M.C.M., Chronic orofacial pain in southern Chinese people: Prevalence, associated disability and help-seeking behaviour, Society of Oral Physiology. 2007, 25: 30.

 

McMillan A.S., Tsang P.C.S., Wong M.C.M. and Kam Y.L., Efficacy of a novel lubricating system in the management of radiotherapy-related xerostomia, Oral Oncology. 2006, 42(8): 842-8.

 

McMillan A.S., Pow E.H.N., Kwong D.L.W., Wong M.C.M., Sham J.S.T., Leung L.H.T. and Leung W.K., Preservation of quality of life after intensity-modulated radiotherapy for early-stage nasopharyngeal carcinoma: Results of a prospective longitudinal study, Head & Neck. 2006, 28: 712-722.

 

McMillan A.S., Wong M.C.M., Zheng J. and Lam C.L.K., Prevalence of Orofacial Pain and Treatment Seeking in Hong Kong Chinese, Journal of Orofacial Pain. 2006, 20: 218-225.

 

Pow E.H.N., Leung W.K., McMillan A.S. and Kwong D.L.W., Oral yeast colonization in southern Chinese nasopharyngeal carcinoma survivors., 20th Annual Scientific Meeting, Faculty of Dentistry, The University of Hong Kong. 2006.

 

Pow E.H.N., Kwong D.L.W., McMillan A.S., Wong M.C.M., Sham J.S.T., Leung L.H.T. and Leung W.K., Xerostomia and quality of life after intensity-modulated radiotherapy vs. conventional radiotherapy for early-stage nasopharyngeal carcinoma: Initial report on a randomized control clinical trial., International Journal of Radiation Oncology, Biology, Physics. 2006, 66: 981-991.

 

Tsang P.C.S., Ng H. and McMillan A.S., Antifungal susceptibility of Candida albicans biofilms on titanium discs with different surface roughness, Clinical Oral Investigations. 2007, Epub ahead of print.

 

Tsang P.C.S., Ng H. and McMillan A.S., SEM study of candidal-biofilms on titanium with different surface roughness, 84th General Session & Exhibition of the IADR 2006.. 2006.

 

Wong A.T.Y., McMillan A.S. and McGrath C.P.J., Oral health-related quality of life and severe hypodontia, Journal of Oral Rehabilitation. 2006, 33: 869-873.

 

Researcher : Newsome PRH

Project Title:

All-porcelain crowns in general dental practice. A qualitative and clinical study

Investigator(s):

Newsome PRH

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2006

 

Abstract:

Restorative dentistry has changed dramatically in recent years. The introduction of a variety of indirect all-porcelain crown systems (eg Empress II. Cercon, Procera) has allowed dentists to place restorations that are not only aesthetic but also durable and conservative. Case selection, material choice, appropriate tooth preparation and cementation of such restorations are, however, considered to be critical and demand close adherence to a set of clinical principles if they are to be successful. Little is known of a) dentists' views and accordingly the willingness of dentists to offer them to their patients and b) the clinical ability of dentists to conform to the aforementioned principles. The aim of this research is to explore the use of such restorations in dental practice. It will also examine the level and nature of communication between dentists and laboratories, widely viewed as a critical determinant of success. Specificically, it is proposed to examine Hong Kong dentists': 1) opinions of, and experience with, the new generation of all-porcelain restorations 2) understanding of accepted principles regarding case selection and tooth preparation with respect to all-porcelain restorations 3) communication with the dental laboratory 4) assessment of all-porcelain restorations supplied by the dental laboratory

 

List of Research Outputs

 

McGrath C.P.J. and Newsome P.R.H., Patient-Centred Measures in Dental Practice: 2. Qualify of Life, Dental Update. 2007, 34: 41-44.

 

Newsome P.R.H., Ceramic Veneers. A Practical Approach for the General Practitioner, Lecture to General Dental Practitioners, Swindon UK.. Swindon, UK, 2007.

 

Newsome P.R.H., Loss leaders in Dentistry - a fresh look at an old idea, Harrogate UK., British Dental Conference and Exhibition. Harrogate, UK, 2007.

 

Newsome P.R.H. and McGrath C.P.J., Patient-Centred Measures in Dental Practice: 3. Patient Satisfaction, Dental Update. 2007, 34: 87-90.

 

Newsome P.R.H. and McGrath C.P.J., Patient-Centred Measures in Dental Practice: Part 1. An overview, Dental Update. 2006, 33: 596-600.

 

Newsome P.R.H., The Business of Dentistry. One day course to Oxident General Dental Practitioner Group, Oxford UK., UK, 2006.

 

Researcher : Ng H

List of Research Outputs

 

Tsang P.C.S., Ng H. and McMillan A.S., SEM study of candidal-biofilms on titanium with different surface roughness, 84th General Session & Exhibition of the IADR 2006.. 2006.

 

Researcher : Ng RPY

List of Research Outputs

 

Chan A.W.K., Low D.C.Y., Cheung G.S.P. and Ng R.P.Y., A questionnaire survey of endodontic practice profile among dentists in Hong Kong, Hong Kong Dental Journal. 2006, 3: 80-87.

 

Researcher : Ng SKS

List of Research Outputs

 

Ng S.K.S. and Leung W.K., A community study on the relationship between stress, coping, affective dispositions and periodontal attachment loss, Community Dentistry and Oral Epidemiology. 2006, 34: 252-266.

 

Researcher : Pan H

List of Research Outputs

 

Pan H. and Darvell B.W., Tetracalcium phosphate and brushite solubility by solid titration, 85th General Session & Exhibition of the IADR, New Orleans, Louisiana, USA, 21-24 March 2007. abstract 1076.

 

Researcher : Parahitiyawa NB

List of Research Outputs

 

Samaranayake Y.H., Samaranayake L.P., Cheung B.P.K., Parahitiyawa N.B., Yau J.Y.Y. and Yeung S.K.W., Inhibitory Effect of Lysozyme and antifungals against Candida albicans biofilms, Journal of Dental Research. New Orleans March 21-24, 85th General Session & Exhibition of the IADR, 2007, 86: Special Issue A.

 

Researcher : Pow EHN

Project Title:

Oral yeast profile of nasopharyngeal carcinoma patients after intensity-modulated radiotherapy

Investigator(s):

Pow EHN, McMillan AS, Leung WK

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

 

Abstract:

To investigate oral colonization and phenotypic profile of oral yeasts in nasopharyngeal carcinoma (NPC) patients receiving conventional radiotherapy (CT) versus intensity-modulated radiotherapy (IMRT).

 

Project Title:

The impact of adjuvant chemotherapy on the quality of life of patients receiving radiotherapy for nasopharyngeal carcinoma

Investigator(s):

Pow EHN, McMillan AS, Kwong DLW, Wong MCM

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

12/2006

 

Abstract:

To compare oral health related quality of life in nasopharyngeal carcinoma (NPC) patients receiving radiotherapy (RT) versus radiotherapy plus chemotherapy (RTCH)

 

List of Research Outputs

 

Lee P.W.H., Kwan T.T., Kwong D.L., Sham J.S., Pow E.H.N., McMillan A.S. and Au G.K., A prospective study of the impact of nasopharyngeal cancer and radiotherapy on the psychosocial condition of Chinese patients., Cancer. 2007, 109: 1344-54.

 

McMillan A.S., Pow E.H.N., Kwong D.L.W., Wong M.C.M., Sham J.S.T., Leung L.H.T. and Leung W.K., Preservation of quality of life after intensity-modulated radiotherapy for early-stage nasopharyngeal carcinoma: Results of a prospective longitudinal study, Head & Neck. 2006, 28: 712-722.

 

Pow E.H.N., Oral health and quality of life after intensity-modulated head and neck radiotherapy for nasopharyngeal carcinoma., PhD thesis, The University of Hong Kong. Hong Kong, 2006, 1-350.

 

Pow E.H.N., Leung W.K., McMillan A.S. and Kwong D.L.W., Oral yeast colonization in southern Chinese nasopharyngeal carcinoma survivors., 20th Annual Scientific Meeting, Faculty of Dentistry, The University of Hong Kong. 2006.

 

Pow E.H.N., Kwong D.L.W., McMillan A.S., Wong M.C.M., Sham J.S.T., Leung L.H.T. and Leung W.K., Xerostomia and quality of life after intensity-modulated radiotherapy vs. conventional radiotherapy for early-stage nasopharyngeal carcinoma: Initial report on a randomized control clinical trial., International Journal of Radiation Oncology, Biology, Physics. 2006, 66: 981-991.

 

Researcher : Rabie ABM

Project Title:

Gene therapy to induce mandibular condylar growth using AAV-VEGF vectors

Investigator(s):

Rabie ABM, Hagg EUO

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

Completion Date:

10/2006

 

Abstract:

To determine and characterize the effect of over-expression of VEGF on mandibular condylar growth with AAV-VEGF vectors, to further characterize the potential of such a system for future clinical trials.

 

Project Title:

Use of micro-implants in orthodontics

Investigator(s):

Rabie ABM, Wong RWK

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

01/2006

 

Abstract:

To investigate the use of mini-implant in orthodontics

 

Project Title:

A novel treatment for Skeletal Class II malocclusion in young adults - a Bone Borne Mandibular Distractor

Investigator(s):

Rabie ABM, Cheung LK, Wong RWK, Dyson JE

Department:

Dental Faculty

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

10/2006

 

Abstract:

(1) Enhancing the reactivation of condylar growth in young adults and late adolescents based on findings in experimental and clinical research. We aim to increase the skeletal component of the correction by avoiding the proclination of the lower incisors that occurs with the Herbst appliance. This reduces the overjet, the amount of advancement and skeletal correction. (2) The forces that this distractor will be exposed to in situ and hence the requisite bone plate configurations, screw length and diameter will be investigated. (3) The question of how to evaluate the response to treatment will also be addressed. In addition to traditional radiographic methods we will use new developments in 3D Magnetic Resonance Imaging.

 

Project Title:

Effect of naringin on oral microgranisms

Investigator(s):

Rabie ABM, Wong RWK

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

01/2007

 

Abstract:

IntroductionExtensive research has been done in the search of ideal bone grafting/ bone induction materials. However, bacterial colonization/re-infection of the surgical site has proven to be detrimental on the healing process.Naringin is a flavonoid that can be commonly found in edible citrus fruit. It was proven in our laboratory, that naringin in collagen can significantly increase new bone formed in rabbit skull defects.ObjectiveThe objective of this study will be to evaluate the effect of naringin on the viability and proliferation of oral microbes in vitro. Common oral aerobes, candida species, and anaerobes such as (Actinobacillus actinomycetemocomitans Aa) will be included in the study.

 

List of Research Outputs

 

Alkhal H., Wong R.W.K. and Rabie A.B.M., Poster Presentations: Skeletal age maturation and cervical vertebrae maturation., 20th Annual Scientific Meeting of the Faculty of Dentistry, The University of Hong Kong, 15 December 2006. . 2006.

 

Alkhal H., Wong R.W.K. and Rabie A.B.M., Skeletal maturation and cervical vertebrae, Surgical Practice. 2006, Vol 10, supplement: A99.

 

Alkhal H.A., Wong R.W.K. and Rabie A.B.M., The use of lateral cephalometric radiographs to determine skeletal maturation in Chinese, The Second Cross-Strait Four Regions Orthodontic Conference, Nanjing, China, 19 – 21 November, 2006. . 2006.

 

Alkhal H.A., Wong R.W.K. and Rabie A.B.M., Use of the cervical vertebrae maturation method the growth spurt determination , 83rd Congress of the European Orthodontic Society, Berlin, Germany, 20-24 June. 2007.

 

Bendeus S.A.M., Song Y. and Rabie A.B.M., Microarray analysis of angiogenic genes in condylar cartilage, 82nd Congress of the European Orthodontic Society. 2006.

 

Cendekiawan T., Rabie A.B.M. and Wong R.W.K., Oral Presentations - Expression of SOX 9 and type II collagen in the spheno-occipital synchondrosis, 83rd Congress of the European Orthodontic Society, Berlin, Germany, 20-24 June. 2007.

 

Dai J. and Rabie A.B.M., Direct AAV-mediated gene delivery to the temporomandibular jonit, Frontiers in Bioscience. 2007, 12: 2212-2220.

 

Dai J. and Rabie A.B.M., RAAV-mediated gene delivery to the mandibular condyle, 82nd Congress of the European Orthodontic Society. 2006.

 

Dai J. and Rabie A.B.M., Recombinant adeno-associated virus vector hybrids efficiently target different skeletal cells, Frontiers in Bioscience. 2007, 12: 4280-4287.

 

Dai J. and Rabie A.B.M., The use of recombinant adeno-associated virus for skeletal gene therapy, Orthodontics Craniofacial Research. 2007, 10: 1-14.

 

Edmad B.A.S.S.E.M., Sherif E.L.-.M.O.F.T.Y., Wong R.W.K., Bendeus S.A.M. and Rabie A.B.M., Vacular Endthelial Growth Factor Augments the Healing of Demineralized Bone Matrix Grafts, International Journal of Surgery. 2006, 4: 160-166.

 

Hagg E.U.O., Song Y. and Rabie A.B.M., Microarray analysis of chondrogenic genes in condylar cartilage, 82nd Congress of the European Orthodontic Society. 2006.

 

Hou H.M., Hagg E.U.O., Sam K., Rabie A.B.M., Wong R.W.K., Lam B. and Ip M.S.M., Dentofacial Characteristics of Chinese Obstructive Sleep Apnea Patients in Relation to Obesity and Severity, The Angle Orthodontist. 2006, 76 No.6: 962-969.

 

Lee C.K., Rabie A.B.M., Wong R.W.K. and McGrath C.P.J., Poster Presentations: Comparison of pain level in microimplant surgery versus other orthodontic procedures. , 20th Annual Scientific Meeting of the Faculty of Dentistry, The University of Hong Kong, 15 December 2006.. 2006.

 

Lee T.C., Rabie A.B.M., Wong R.W.K. and McGrath C.P.J., Patients perception to microimplant as anchorage in orthodontics , 83rd Congress of the European Orthodontic Society, Berlin, Germany, 20-24 June. 2007.

 

Lee T.C.K., Rabie A.B.M., Wong R.W.K. and McGrath C.P.J., Patients’ Perception To Micro-implant as Anchorage in Orhodontics, The Second Cross-Strait Four Regions Orthodontic Conference, Nanjing, China, 19 – 21 November, 2006. . 2006.

 

Lei W.Y., Rabie A.B.M. and Wong R.W.K., Factors regulating endochondral ossification in spheno-occipital synchondrosis, 83rd Congress of the European Orthodontic Society, Berlin, Germany, 20-24 June. 2007.

 

Leung M.T., Rabie A.B.M. and Wong R.W.K., Stability of connected micro-implants and miniplates for skeletal anchorage, 83rd Congress of the European Orthodontic Society, Berlin, Germany, 20-24 June. 2007.

 

Leung M.T.C., Rabie A.B.M. and Wong R.W.K., Oral Presentation: Stability of connected micro-implants and mini-plates for orthodontic skeletal anchorage. , 20th Annual Scientific Meeting of the Faculty of Dentistry, The University of Hong Kong, 15 December 2006. . 2006.

 

Phan K.L.D., Bendeus S.A.M., Hagg E.U.O., Hansen K. and Rabie A.B.M., Comparison of the headgear activator and Herbst appliance - effects and post-treatment changes, European Journal of Orthodontics. 2006, 28 No.1: 594-604.

 

Purkayastha S.K., Rabie A.B.M. and Wong R.W.K., Orthopaedic correction of skeletal class II adult patients, 83rd Congress of the European Orthodontic Society, Berlin, Germany, 20-24 June. 2007.

 

Purkayastha S.K., Rabie A.B.M. and Wong R.W.K., Poster Presentations: Correction of mandibular retrognathism in mature individuals using the herbst appliance. , 20th Annual Scientific Meeting of the Faculty of Dentistry, The University of Hong Kong, 15 December 2006. . 2006.

 

Rabie A.B.M., Wong R.W.K. and King N.M., Aesthetic Dentistry and Orthodontics, The Hong Kong Medical Diary. 2006, Vol. 11 No.8: 7-11.

 

Rabie A.B.M., Bone induction using traditional Chinese medicine, 21st Congress of Interntional Association of Paediatric Dentistry, Hong Kong. 2007.

 

Rabie A.B.M., Editorial Board Member, The Open Dentistry Journal. 2007.

 

Rabie A.B.M., Gene therapy to enhance condylar growth, 83rd Congress of the European Orthodontic Society. 2007.

 

Rabie A.B.M., Gene therepay to enhnce condylar growth; Treatment of Class II malocclusion in growing patients: clnical & experimental prospective; Non-surgical approach for the correction of Class II malocclusion in audlt patients, 11th International Congress of Orthodontics, Santiago, Chile. 2006.

 

Rabie A.B.M., Graduate orthodontic education in the University of Hong Kong; Experimental and clinical advances in the treatment of Class II in growing children; Successful use of gene therapy to enhance jaw growth, 2nd Aozora Seminar, Tokyo, Japan. 2006.

 

Rabie A.B.M., Hagg E.U.O., Wong R.W.K. and Al K.A.A.A., Indian Hedgehog is a mechanotransduction mediator in mandibular condyles., Biological Mechanisms of Tooth Eruption, Resorption, and Movement - Proceedings of the Eighth International Conference, Phuket, Thailand, 2005. Eds. Davidovitch Z., Mah J. and Suthanarak S., University of South California, School of Dentistry . 2006, 179-189.

 

Rabie A.B.M. and Dai J., Infection efficiency of rat chondrocyties using different hybrids of RAAV vectors, 82nd Congress of the European Orthodontic Society. 2006.

 

Rabie A.B.M. and Wong R.W.K., Management of Patients with Severe Bone Loss:Bone Induction and Orthodontics, The Philippine Journal of Orthodontics. 2006, Vol.5 No.1: 1-7.

 

Rabie A.B.M., Management of patients with severe bone loss: bone induction and orthodontics, 15th Alexandria International Dental Congress, Alexandria, Egypt. 2006.

 

Rabie A.B.M., Non-surgical approach for the correction of Class II malocclusion in young adults; Management of patients with severe bone loss: bone induction and orthodontics; The interphase between esthethic dentistry, orthodontics and periodontics, 5th Jordanian Orthodontic Congress, Amman, Jordan. 2006.

 

Rabie A.B.M., Dai J. and Xu R., Recombinant AAV-mediated VEGF gene therapy induces mandibular condylar, Gene Therapy. 2007, 14: 978-980.

 

Rabie A.B.M., Regeneration of the Periodontium to achieve stability in adults with severe bone loss, 22nd Congress of the European Begg Society of Orthodontists, Rotterdam, The Netherlands. 2007.

 

Rabie A.B.M., Reviewer, Gene Thereapy. 2006.

 

Rabie A.B.M., The interephase between esthetic dentistry, orthodontics and periodontics, 41st Indian Orthodontic Conference, Chennai, India. 2006.

 

Rukkulchon K., Wong R.W.K. and Rabie A.B.M., Effect of tensile force on the expression of PTHRP in mouse synchondrosis, 83rd Congress of the European Orthodontic Society, Berlin, Germany, 20-24 June. 2007.

 

Song Y., Rabie A.B.M. and Wong R.W.K., Microarray Analysis of Mandibular Condyle under Mechanical Strain , 82nd Congress of the European Orthodontic Society in Vienna, Austria, 4 – 8 July, 2006.. 2006.

 

Tsui V.W., Rabie A.B.M. and Wong R.W.K., A novel antimicrobial agent, 83rd Congress of the European Orthodontic Society, Berlin, Germany, 20-24 June. 2007.

 

Tsui V.W.K., Rabie A.B.M. and Wong R.W.K., Effects of naringin on periodontal pathogens and oral microorganisms, Merit for the Outstanding Oral Presentation (Junior Category). Awarded by the 20th Annual Scientific Meeting of the Faculty of Dentistry, The University of Hong Kong, 15 December, 2006. 2006.

 

Tsui V.W.K., Rabie A.B.M. and Wong R.W.K., Oral Presentation: Effects of naringin on periodontal pathogens and oral microorganisms., 20th Annual Scientific Meeting of the Faculty of Dentistry, The University of Hong Kong, 15 December 2006. . 2006.

 

Tsui V.W.K., Rabie A.B.M. and Wong R.W.K., The Effects of Naringin on the Growth of Periodontal Pathogens in Vitro, The Best Research Paper. Awarded by the Hong Kong Society of Orthodontists at the 2nd Cross Strait 4 Regions Orthodontics Conference, Nanjing, China, 12 December, 2006. 2006.

 

Tsui V.W.K., Rabie A.B.M. and Wong R.W.K., The effects of naringin on the growth of periodontal pathogens in vitro’, The Second Cross-Strait Four Regions Orthodontic Conference, Nanjing, China, 19 – 21 November, 2006. . 2006.

 

Wey M.C., Bendeus S.A.M., Peng L., Hagg E.U.O., Rabie A.B.M. and Robinson W., Stepwise advancement versus maximum jumping with headgear activator, European Journal of Orthodontics. 2007, 29: 283-293.

 

Wong R.W.K. and Rabie A.B.M., Bone formation using puerarin graft., 20th Annual Scientific Meeting of the Faculty of Dentistry, The University of Hong Kong, 15 December 2006. . 2006.

 

Wong R.W.K. and Rabie A.B.M., Bone induction using puerarin, 83rd Congress of the European Orthodontic Society, Berlin, Germany, 20-24 June. 2007.

 

Wong R.W.K., Alkhal H. and Rabie A.B.M., Cervical Vertebra Maturation in Southern Chinese Subjects , 82nd Congress of the European Orthodontic Society in Vienna, Austria, 4 – 8 July, 2006.. 2006.

 

Wong R.W.K. and Rabie A.B.M., Effect of a phytoestrogen graft on bone formation, Surgical Practice. 2006, Vol 10, suppliment: A6.

 

Wong R.W.K. and Rabie A.B.M., Effect of a phytoestrogen graft on bone formation, The Best Scientific Paper in Dentistry/OMFS. Awarded by the RCSED/CSHK Conjoint Scientific Congress in October 2006 . 2006.

 

Wong R.W.K. and Rabie A.B.M., Effect of puerarin on bone formation , Osteoarthritis and Cartilage. 2007, 15: 894-899.

 

Wong R.W.K. and Rabie A.B.M., HMGCo-A Reductase Inhibitors increase Bone Formation, 82nd Congress of the European Orthodontic Society in Vienna, Austria, 4 – 8 July, 2006. . 2006.

 

Wong R.W.K. and Rabie A.B.M., Invited speaker 'Phytochemicals for bone formation', The second Cross-Strait Four Regions Orthodontic Conference, Nanjing, China, 19 - 21 November, . 2006.

 

Wong R.W.K. and Rabie A.B.M., Osteogenic Effect of Puerarin , MGH-HKU-Nature China Forum, Cheung Kung Hai Conference Centre, Li Ka Shing Faculty of Medicine, The University of Hong Kong Osteogenic. March 5-6, 2007 . 2007.

 

Wong R.W.K. and Rabie A.B.M., Recent Developments on Plant Extracts for bone induction, Recent Developments in Medicinal Plant Research. Research Signpost, Kerala, India.. 2007, Chapter 6: 99-120.

 

Wong R.W.K., Rabie A.B.M. and Hagg E.U.O., The Effect of Crude Extract from Radix Dipsaci on Bone in Mice, Phytotherapy Research. 2007, 21: 596-598.

 

Wong R.W.K. and Rabie A.B.M., ‘Phytochemicals for bone formation, The Second Cross-Strait Four Regions Orthodontic Conference, Nanjing, China, 19 – 21 November, 2006. . 2006.

 

Wu J., Hagg E.U.O. and Rabie A.B.M., Chinese norms of McNamara's cephalometric analysis, Angle Orthodontist. 2007, 77: 12-20.

 

Researcher : Robinson W

List of Research Outputs

 

Wey M.C., Bendeus S.A.M., Peng L., Hagg E.U.O., Rabie A.B.M. and Robinson W., Stepwise advancement versus maximum jumping with headgear activator, European Journal of Orthodontics. 2007, 29: 283-293.

 

Researcher : Sam K

List of Research Outputs

 

Hou H.M., Hagg E.U.O., Sam K., Rabie A.B.M., Wong R.W.K., Lam B. and Ip M.S.M., Dentofacial Characteristics of Chinese Obstructive Sleep Apnea Patients in Relation to Obesity and Severity, The Angle Orthodontist. 2006, 76 No.6: 962-969.

 

Ip M.S.M., Yam L.Y.C., Lam C.L.K. and Sam K., Randomized controlled study of treatment for mild and moderate sleep apnoea, Hong Kong Medical Journal. 2007, 13 (suppl 3): S4-7.

 

Lam B., Sam K., Mok W.Y.W., Cheung M.T., Fong D.Y.T., Lam J.C.M., Lam C.L., Yam L.Y.C. and Ip M.S.M., Randomized study of three non-surgical treatments in mild to moderate obstructive sleep apnea, Thorax. 2007, 62: 354-359.

 

Lam B., Sam K., Lam J.C., Lam C.L., Ku P.P. and Ip M.S.M., The efficacy of oral appliance in the treatment of severe obstructive sleep apnea, American Thoracic Society International Conference, San Francisco, USA. American Jouranl of Respiratory and Critical Care Medicine. 2007, 175: A708.

 

Researcher : Samaranayake LP

Project Title:

Molecular epidemiology of geopraphically diverse oral Candida tropicalis isolates

Investigator(s):

Samaranayake LP

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2002

 

Abstract:

To investigate the RAPD fingerprints of C. tropicalis isolates from varying geographical locales using tDNA and rDNA directed sequence-specific and arbitrary primers in order to asses their genomic heterogeneity; to investigate their intraspecies genetic relatedness as a recent report has hinted the possible existence of a genetic variant of this yeast which may be classified as a new species.

 

Project Title:

Ultrastructural, histochemical and molecular features of the invasive phase of Candida species

Investigator(s):

Samaranayake LP, Cheung LK, Samaranayake YH

Department:

Dental Faculty

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

12/2002

 

Abstract:

The study attempts to:- 1) characterize the ultrastructural cellular features of the three hypha producing Candida species, C. albicans, C. tropicalis and C. dubliniensis, during invasion of the superficial epithelium; 2) determine qualitatively the proteolytic and lipolytic enzymes secreted at the apical tip of the invading fungal hyphae; 3) examine th etemporal regulation of the mRNA expression of seven members of the secreted aspartyl proteinases (SAP) gene family during tissue invasion by C. albicans; and 4) evaluate features mentioned above in well characterized mutants of C. albicans that have a high and low propensity to produce hyphal elements and SAP mutants that have defects in secretion of this protein degrading enzyme.

 

Project Title:

Development and validation of a mutiarray Candida biofilm device

Investigator(s):

Samaranayake LP

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

12/2005

 

Abstract:

Candida species can exist as either commensals or opportunistic pathogens with the ability to cause a variety of superficial to systemic infections mainly in immunocompromised individuals (Samaranayake et al 2002). The major fungal species isolated from these patients is the polymorphic C. albicans (which can grow as blastospores, pseudohyphae or hyphae, and also form chlamydospores) recovered from medical devices such as central venous catheters, prosthetic heart valves, artificial voice prostheses and intrauterine devices (Hawser and Douglas, 1994, Samaranayake et al 2005). The primary event in Candida infections is their adherence to a host surface or a prosthesis leading to the formation of a biofilm which further facilitate adhesion and infection. Once established, Candida biofilms serve as a persistent reservoir of infection and in addition they offer greater resistance to antifungal agents than planktonic phase yeasts Apart from C. albicans other non-albicans species especially, C. glabrata, C. parapsilosis, C krusei and C. tropicalis are increasingly recognized as nosocomial pathogens of clinical interest (Samaranayake 2000). Several different in vitro Candida biofilm model systems have been developed to study the many features of the sessile yeast form in comparison to the planktonic form. These include biofilms grown on intravascular catheter discs, acrylic discs, cylindrical cellulose filters, those developed using perfused biofilm fermenters and the modified Robbins device (Hawser and Douglas, 1994, Ye 2004). Although these experimental systems mimic to some extent the natural in vivo physiology of Candida biofilms a simple, rapid and reproducible, mutiarray method for screening a number of different Candida strains or species and factors that affect their biofilm formation has not yet been developed. Calgary biofilm device (CBD) is a system used by bacteriologists to determine antibiotic susceptibility of multiple arrays of bacteria within a single experimental system (Ceri et al., 1999). We plan to develop the CBD for standardization of C. albicans biofilms and then demonstrate the feasibility of the system to study the relative rate of biofilm production by five other medically important Candida species. In addition we propose to use the CBD method to evaluate the growth kinetics of C. albicans biofilms and, the effect of five different dietary carbohydrates on Candida biofilm development. The biofilm ultrastructure of C. albicans, C. dubliniensis, C. glabrata, C. tropicalis, and C. krusei using the CBD over a period five days will also be studied using SEM. References 1. Ceri H, OlsonME , Stremick C et al (1999) The calgary biofilm device: new technology for rapid determination of antibiotic susceptibilities in bacterial biofilms. J. Clin. Microbiol. 37; 1771–1776 2. Hawser, S. P., and L. J. Douglas. 1994. Biofilm formation by Candida species on the surface of catheter materials in vitro. Infect. Immun. 62:915-921 3. Samaranayake LP Essential microbiology for dentistry Churchill Livingstone 2000 4. Samaranayake LP, Cheung LK, Samaranayake YH Candidiasis and other fungal diseases of the mouth Dermatologic Therapy 2002 ; 15: 252-270. 5. Jin Y, Samaranayake LP, Samaranayake YH, Yip HK. Biofilm Formation of Candida albicans is variably affected by saliva and dietary sugars. Archives of Oral Biology. 2004; 49: 789-798 6. Samaranayake YH , Dassanayake RS Jayatilake JAMS, Cheung BPK, Yau JYY, Yeung KWS, Samaranayake LP Phospholipase B enzyme expression is not associated with other virulence attributes in Candida albicans isolates from patients with human immunodeficiency virus infection Journal of Medical Microbiology 2005 ; 54 : 583-593

 

Project Title:

Effect of oral bacteria on growth and survival of Candida albicans biofilms

Investigator(s):

Samaranayake LP, Samaranayake YH

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

09/2006

 

Abstract:

In nature, most microorganisms exist in polymicrobial communities, and significant proportions persist attached to surfaces in the form of biofilms (Costerton et al., 1987). A biofilm is defined as an assemblage of microorganisms and their extracellular products at an interface and typically attached to an abiotic or biotic surface. It is now known that the complex architecture of most biofilms is intrinsically stratified into spatially organised populations of mixed species communities with a degree of interspecies interaction (El Azizi et al., 2004). Several workers have previously described marked variations in the interactions between bacteria and C. albicans with complex outcomes although none has co-cultured bacteria and yeast for a prolonged period to evaluate biofilm formation. For example, in very early studies Bagg and Silverwood (1986) demonstrated binding of oral streptococci to C. albicans and surmised that such coaggregation was one mechanism by which the opportunistic pathogen C. albicans survives within the hostile oral milieu. Millsap et al., (1999) found the salutary effect of oral streptococci and Actinomyces species on the subsequent adhesion of C. albicans to acrylic surfaces in a parallel plate flow chamber. These and other studies have described essentially the beneficial aspects of such interactions although it is likely that antagonistic interactions also play an important role in a mixed biofilm (Bagg and Silverwood, 1986; Grimaudo et al., 1996; Grimaudo and Nesbitt, 1997). As far as we are aware, there are no studies in the English language literature on the effect of oral bacteria on the C. albicans biofilm development over a prolong period of 48 h. Therefore, the aim of this study is to evaluate the effect of varying concentrations of eight different aerobic and anaerobic oral bacteria on C. albicans biofilm formation. Four different plaque organisms namely Actinomyces israelii, Lactobacillus acidophilus, Streptococcus mutans, Streptococcus intermedius, and two periodontopathic, black-pigmented, anaerobes, Prevotella nigrescens, and Porphyromonas gingivalis and two transient oral colonizers, Pseudomonas aeruginosa, and Escherichia coli.ReferencesBagg, J. and Silverwood, R. W. (1986). J. Med. Microbiol. 22: 165-169.Costerton, J. W. et al. (1987). Annu. Rev. Microbiol. 41: 435-464.El Azizi, M. A. et al. (2004). J. Appl. Microbiol. 96: 1067-1073. Grimaudo, N. J. et al. (1996). Oral Microbiol. Immunol. 11: 59-61.Grimaudo, N. J. and Nesbitt, W. E. (1997). Oral Microbiol. Immunol. 12: 168-173.

 

Project Title:

Candida biofilms: molecular mechanisms and clinical implications

Investigator(s):

Samaranayake LP, Samaranayake YH, Jin LJ, Wang Y

Department:

Dental Faculty

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

12/2006

 

Abstract:

To compare the gene and protein expression, relevant to its virulent attributes, in sessile and palnktonic phase Candida on an inert surface and an epithelial surface; to evaluate the biofilm-associated drug resistance of C. albicans to three representative, commonly used, major antifungal agents: amphotericin B (polyene group), fluconazole (azole group) and capsofungin (echinocandin group); to characterize the effects of three innate mucosal defense constituents: lactoferrin, histatins and defensins on Candida biofilms.

 

List of Research Outputs

 

Ariyawardana A., Panagoda G.J., Fernando H.N., Ellepola A.N.B., Tilakaratne W.M. and Samaranayake L.P., Oral submusous fibrosis and oral yeast carriage - a case control study in Sri Lankan patients, Mycoses . Blackwell, 2007, 50: 116-120.

 

Dassanayake R.S., Samaranayake Y.H., Yau J.Y.Y. and Samaranayake L.P., DNA fingerprinting elecited evolutionary trend of oral candida tropicalis isolates from diverse geographic locales , Indian Journal of Medical Microbiology. 2006, 24(3): 186-94.

 

Jayatilake J.A.M.S., Samaranayake L.P., Lu Q. and Jin L.J., IL-Ia, IL-Ira and IL-8 are differentially induced by Candida in experimental oral candidiasis, Oral Diseases. Blackwell Munksgaard, 2007, 13: 426-433.

 

Reichart P.A., Samaranayake L.P., Bendick C.H..., Schmidt-Westhausen A.M. and Jayatilake J.A.M.S., Prevalence of oral Candida species in leprosy patients from Cambodia and Thailand, Journal of Oral Pathology and Medicine. Blackwell Munksgard, 2007, 36: 342-346.

 

Samaranayake L.P., Essential Microbiology for Dentistry, Essential Microbiology for Dentistry. UK, Churchill Livingstone, 2006, Third edition, Edinburgh: PP360.

 

Samaranayake L.P., Good antimicrobial prescribing (Part I): the dental practitioner and antimicrobial therapy , Dental Asia. 2006, p23-26.

 

Samaranayake L.P., Saliva tells the body's health In:, The benefits of Chewing . New York, USA, 2006, (ed Stephen Moss): p24-35.

 

Samaranayake Y.H., Dassanayake R.S., Cheung B.P.K., Jayatilake J.A.M.S., Yeung S.K.W., Yau J.Y.Y. and Samaranayake L.P., Differential phospholipase gene expression by Candida albicans in artificial media and cultured human oral epithelium, APMIS. 2006, 114: 857-66.

 

Samaranayake Y.H., Samaranayake L.P., Cheung B.P.K., Parahitiyawa N.B., Yau J.Y.Y. and Yeung S.K.W., Inhibitory Effect of Lysozyme and antifungals against Candida albicans biofilms, Journal of Dental Research. New Orleans March 21-24, 85th General Session & Exhibition of the IADR, 2007, 86: Special Issue A.

 

Yip H.K., Tsang P.C.S., Samaranayake L.P. and Li A.H.P., Knowledge of and attitudes toward severe acute respiratory syndrome among a cohort of dental patients in Hong Kong following a major local outbreak, Community Dental Health. 2007, 24: 43-48.

 

Zaw M.T., Samaranayake Y.H. and Samaranayake L.P., Effect of oral bacteria on growth and survival of Candida albicans biofilms, Archives of Oral Biology. 2006, 51: 672-680.

 

Zaw M.T., Samaranayake Y.H. and Samaranayake L.P., In vitro biofilm formation of Candida albicans and non-albicans Candida species under dynamic and anaerobic conditions, Archives of Oral Biology. Elsevier, 2007, 52: 761-767.

 

Researcher : Samaranayake YH

Project Title:

Genomic basis of fluconazole resistance in C.glabrata

Investigator(s):

Samaranayake YH, Samaranayake LP

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

Completion Date:

10/2006

 

Abstract:

To obtain a drug resistant C. glabrata strain by sequential exposure to sub-minimal inhibitory concentrations of fluconazole; to determine cell viability (by ATP measurement) after drug exposure and observe the morphological changes by SEM.

 

List of Research Outputs

 

Dassanayake R.S., Samaranayake Y.H., Yau J.Y.Y. and Samaranayake L.P., DNA fingerprinting elecited evolutionary trend of oral candida tropicalis isolates from diverse geographic locales , Indian Journal of Medical Microbiology. 2006, 24(3): 186-94.

 

Samaranayake Y.H., Dassanayake R.S., Cheung B.P.K., Jayatilake J.A.M.S., Yeung S.K.W., Yau J.Y.Y. and Samaranayake L.P., Differential phospholipase gene expression by Candida albicans in artificial media and cultured human oral epithelium, APMIS. 2006, 114: 857-66.

 

Samaranayake Y.H., Samaranayake L.P., Cheung B.P.K., Parahitiyawa N.B., Yau J.Y.Y. and Yeung S.K.W., Inhibitory Effect of Lysozyme and antifungals against Candida albicans biofilms, Journal of Dental Research. New Orleans March 21-24, 85th General Session & Exhibition of the IADR, 2007, 86: Special Issue A.

 

Zaw M.T., Samaranayake Y.H. and Samaranayake L.P., Effect of oral bacteria on growth and survival of Candida albicans biofilms, Archives of Oral Biology. 2006, 51: 672-680.

 

Zaw M.T., Samaranayake Y.H. and Samaranayake L.P., In vitro biofilm formation of Candida albicans and non-albicans Candida species under dynamic and anaerobic conditions, Archives of Oral Biology. Elsevier, 2007, 52: 761-767.

 

Researcher : Samman N

Project Title:

Distraction versus orthognathic surgery - which one is better for cleft palate patients?

Investigator(s):

Samman N, Cheung LK, Whitehill TL, Ho MY, Bendeus SAM, Chua HDP

Department:

Dental Faculty

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

01/2006

 

Abstract:

To compare the clinical morbidity of distraction and orthognathic surgery in cleft palate Le Fort I osteotomy; to compare the skeletal and dental relapse of distraction and conventional Le Fort I osteotomy in 3 dimensions; to compare the speech and velopharyngeal function results of distraction and conventional Le Fort I osteotomy; to compare the psychological impact of cleft orthognathic surgery versus distraction osteogenesis in CLP patients.

 

List of Research Outputs

 

Chanchareonsook N., Whitehill T.L. and Samman N., Speech Outcome and Velopharyngeal Function in Cleft Palate: Comparison of Le Fort I Maxillary Osteotomy and Distraction Osteogenesis—Early Results, The Cleft Palate-craniofacial Journal. USA, American Cleft Palate-Craniofacial Association, 2007, 44(1): 23-32.

 

Chanchareonsook N., Whitehill T.L., Samman N. and Cheung L.K., Speech outcome and velopharyngeal function in Cantonese cleft patients: comparison of Le Fort I maxillary osteotomy and distraction osteogenesis - a pilot study, Asian J Oral Maxillofac Surg. 2006, 18, no. 3 (suppl 1): p. 30-31.

 

Chanchareonsook N..., Samman N. and Whitehill T.L., Speech outcome and velopharyngeal function in cleft palate: comparison of Le Fort I Maxillary osteotomy and distraction osteogenesis - early results, Cleft Palate Craniofacial Journal. 2007, 44 (1): p. 23-32.

 

Chanchareonsook N..., Samman N. and Whitehill T.L., The effect of cranio-maxillofacial osteotomies and distraction osteogenesis on speech and velopharyngeal status: a critical review, Cleft Palate - Craniofacial Journal. 2006, 43 (4): p. 477-487.

 

Cheung L.K., Chua H.D.P., Whitehill T.L., Ho M.Y., Bendeus S.A.M. and Samman N., Cleft distraction versus orthognathic surgery - which is more stable? , XVIII Congress of the European Association for Cranio-Maxillo facial Surgery, Barcelona, Spain. 2006.

 

Chow R.L.K., Singh B..., Chiu W.K. and Samman N., Prevalence of postoperative complications after orthognathic surgery: a 15-year review, Journal of Oral and Maxillofacial Surgery. 2007, 65: p. 984-992.

 

Chua H.D.P., Whitehill T.L., Samman N. and Cheung L.K., Cleft distraction versus orthognathic surgery - which one cause less disturbance on resonance?, J Cranio-maxillofac Surg. 2006, 34 (suppl. S1): p. 37.

 

LAU S.L. and Samman N., Evidence-based practice in oral and maxillofacial surgery: audit of 1 training center, Journal of Oral and Maxillofacial Surgery. 2007, 65(4): 651-7.

 

LAU S.L. and Samman N., Levels of evidence and journal impact factor in oral and maxillofacial surgery, International Journal of Oral and Maxillofacial Surgery. 2007, 36(1): 1-5.

 

Lau A... and Samman N., Evidence-based practice in oral and maxillofacial surgery. Audit of one training centre. 18th Congress of the European Association for Craniomaxillofacial Surgery, September 2006, Barcelona, Spain, Journal of Cranio-Maxillofacial Surgery. 2006, 34: Suppl S1, p. 129.

 

Lau S...L... and Samman N., Evidence-based practice in oral and maxillofacial surgery. An audit of one training centre, Asian J Oral Maxillofac Surg. 2006, 18, No. 3 (suppl 1): p. 45.

 

Lau S...L... and Samman N., Levels of evidence and journal impact factor in oral and maxillofacial surgery, 20th Annual Scientific Meeting of the Faculty of Dentistry, University of Hong Kong. 2006, Abstract O5, p. 16.

 

Lau S...L... and Samman N., Recurrence related to treatment modalities of unicystic ameloblastoma: a systematic review, 20th Annual Scientific Meeting of the Faculty of Dentistry, University of Hong Kong. 2006, Abstract O17, p. 22.

 

Lau S...L... and Samman N., Recurrence related to treatment modalities of unicystic ameloblastoma: a systematic review, Asian J Oral Maxillofac Surg. 2006, 18, No. 3 (suppl 1): p. 45.

 

Lau S...L... and Samman N., Recurrence related to treatment modalities of unicystic ameloblastoma: a systematic review, International Journal of Oral and Maxillofacial Surgery. 2006, 35: p. 681-690.

 

Lau S...L... and Samman N., Recurrent related to treatment modalities of unicystic ameloblastoma: a systematic review, Surgical Practice. 2006, 10 ( Suppl): p. A7.

 

Lee S., McGrath C.P.J. and Samman N., Quality of life in patients with dentofacial deformity: a comparison of measurement approaches, International Journal of Oral and Maxillofacial Surgery. 2007, 36: 488-492.

 

Lee S.H.E.R.M.I.N., McGrath C.P.J. and Samman N., Quality of life of patients with dentofacial deformity, Asian Journal of Oral and Maxillofacial Surgery. 2006, 18, No. 3 (suppl 1): p. 45-46.

 

Samman N., Current Oral and Maxillofacial Surgery Training and Education in Asia, 2007 Annual Scientific Meeting, Chinese Taipei Medical Association, Taipei. 2007.

 

Samman N., Current Oral and Maxillofacial Surgery Training and Education in Asia, Proceedings of the 2007 Annual Scientific Meeting of the Chinese Medical Association - Taipei, June 2007. JCMA 70: Suppl: 120-121.

 

Samman N., Editor-in-Chief (2000-2006), Asian Association of Oral and Maxillofacial Surgeons. 2006.

 

Samman N., Editor-in-Chief (since 2000), Asian Journal of Oral & Maxillofacial Surgery. 2006.

 

Samman N., International Advisory Board (since 2003), China Journal of Oral and Maxillofacial Surgery. 2006.

 

Samman N., Keynote address - Oral and Maxilofacial Surgery: Current focus in basic and clinical research, 84th General Session of the International Association for Dental Research, J Dent Res, Brisbane, Australia. 2006, Seq # 204 : 2503.

 

Samman N., Mandibular reconstruction - an overview (Inaugural Lecture as Visiting Professor), Mahidol University, Faculty of Dentistry, Bangkok, Thailand, February 2007. 2007.

 

Samman N., Mandibular reconstruction - options available and rationale for selection - Special Lecture, 51st Annual Meeting of the Japanese Society of Oral and Maxillofacial Surgery. Kitakyushu City, Fukuoka Prefecture, Japan.. 2006.

 

Samman N., Mandibular reconstruction - options available and rationale for selection, Japanese Journal of Oral & Maxillofacial Surgery. 2006, 52 (suppl): p. 10-11.

 

Samman N., Member of the Editorial Board (since 1997), Chinese Journal of Oral and Maxillofacial Surgery. 2006.

 

Samman N., Principles of comprehensvie surgical care for cleft lip and palate. Smart, Smile and Speech Project, Cleft Lip and Palate Treatment Project for 50th Celebration of Princess of Thailand, Hat Yai, Thailand. June 2007. 2007.

 

Samman N., Revision surgery for severe secondary cleft lip deformity, International Conference on Oral and Maxillofacial Surgery, Antalya, Turkey. May 2007. 2007.

 

Samman N., Section Chairman (Since 2001 Clinical Pathology) , International Journal of Oral and Maxillofacial Surgery. 2006.

 

Samman N., Surgery for CLP children in Hong Kong: a hierarchy of priorities. Symposium S4 - Cleft Lip and Palate, 21st Congress of International Association of Paediatric Dentistry (IAPD). Hong Kong, China. 2007.

 

Samman N., Surgery for cleft lip and palate children in Hong Kong: hierarchy of priorities, 21st Congress of the International Association of Paediatric Dentistry, June 2007, Hong Kong, Program Book. 2007, Symposium S4.

 

Yeung R.W.K., Samman N. and Xia J.J., Image-guided minimally invasive surgical access to the temporomandibular joint: a preliminary report, Journal of Oral and Maxillofacial Surgery. 2006, 64: 1546-1552.

 

Yeung R.W.K., Samman N., Chow R.L.K. and Chiu W.K., Short-term therapeutic outcome of intra-articular high molecular weight hyaluronic acid injection for non-reducing disc displacement of the temporomandibular joint, Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology & Endodontics. 2006, 102 (4): p. 453-461.

 

Yeung R.W.K., Samman N., Cheung L.K., Zhang C...P... and Chow R.L.K., Stereomodel-assisted fibula flap harvest and mandibular reconstruction, Journal of Oral and Maxillofacial Surgery. 2007, 65: p.1128-1134.

 

Researcher : Sham ASK

List of Research Outputs

 

McGrath C.P.J., Sham A.S.K., Ho D.K.L. and Wong J.H.L., The impact of dental neglect on oral health: a population based study in Hong Kong, International Dental Journal. 2007, 57: 3-8.

 

Researcher : She TT

List of Research Outputs

 

Chien A.Y.J., She T.T., Jin L.J., McGrath C.P.J. and Corbet E.F., Quality of life and orthodontic correction of incisor drifting, Journal of Dental Research. 2006, 85 (Spec Iss B): 420 (PEF).

 

Researcher : Shi X

List of Research Outputs

 

Cheung L.K., Shi X. and Zheng L., Surgical induction of temporomandibular joint ankylosis: an animal model, Journal of Oral and Maxillofacial Surgery. 2007, 65: p. 993-1004.

 

Researcher : Shum IHY

List of Research Outputs

 

Jin L.J., Shum I.H.Y., Leung P.C., Lau E., Kwok A. and Orwoll E.S., Periodontal conditions in Hong Kong Chinese men with osteoporosis/osteopenia, Journal of Dental Research. 2007, 86 (Spec Iss A): 645.

 

Researcher : Song Y

List of Research Outputs

 

Bendeus S.A.M., Song Y. and Rabie A.B.M., Microarray analysis of angiogenic genes in condylar cartilage, 82nd Congress of the European Orthodontic Society. 2006.

 

Hagg E.U.O., Song Y. and Rabie A.B.M., Microarray analysis of chondrogenic genes in condylar cartilage, 82nd Congress of the European Orthodontic Society. 2006.

 

Song Y., Rabie A.B.M. and Wong R.W.K., Microarray Analysis of Mandibular Condyle under Mechanical Strain , 82nd Congress of the European Orthodontic Society in Vienna, Austria, 4 – 8 July, 2006.. 2006.

 

Researcher : Tan H

List of Research Outputs

 

Lo E.C.M., Luo Y., Tan H., Dyson J.E. and Corbet E.F., Art and conventional root restorations in elders after 12 months, Journal of Dental Research. 2006, 85: 929-932.

 

Luo Y., Lo E.C.M., Tan H., Dyson J.E. and Corbet E.F., ART and conventional root restorations in elders after 3 years, Journal of Dental Research. 2007, 86 (Spec Iss A): 2435.

 

Researcher : Tideman H

Project Title:

Functional reconstruction of the upper jaw

Investigator(s):

Tideman H, Luk WK

Department:

Dental Faculty

Source(s) of Funding:

Other Funding Scheme

Start Date:

01/1992

 

Abstract:

To restore the function of the upper jaw after ablative surgery with bone and implants.

 

Project Title:

Functional reconstruction of the lower jaw

Investigator(s):

Tideman H, Luk WK

Department:

Dental Faculty

Source(s) of Funding:

Other Funding Scheme

Start Date:

01/1994

 

Abstract:

To restore the function of the lower jaw after ablative surgery with bone and implants.

 

Researcher : Tsang PCS

Project Title:

Clinical, microbiological and histopathological study of oral diseases in renal transplant patients in Hong Kong

Investigator(s):

Tsang PCS, Leung WK, Samaranayake LP, Chan AWK, Chan DTM, Chu FCS

Department:

Dental Faculty

Source(s) of Funding:

Other Funding Scheme

Start Date:

03/2000

 

Abstract:

To obtain baseline data on the oral health in a group of renal transplant patients; to compare the effects of cyclosporin A ad FK506 on oral tissues and oral mciroflora; to investigate the effects of oral health programme on the oral status of these patients, both clinically and microbiologically.

 

Project Title:

In vitro effects of protease inhibitors on the adherence of Candida albicans isolated from HIV-infected patients to buccal epithelial cells

Investigator(s):

Tsang PCS, Samaranayake LP

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2003

Completion Date:

10/2006

 

Abstract:

To investigate the in vitro effect of three common protease inhibitors i.e. Ritonavir, Indinavir and Saquinavir on the adherence of C.albicans, to oral buccal epithelial cells; to determine the optimal concentration of the protease inhibitors in minimizing the adherence of C. albicans (if any), to buccal epithelial cells.

 

Project Title:

Effect of highly active antiretroviral therapy on oral candidiasis in human immunodeficiency virus-infected individuals in Hong Kong

Investigator(s):

Tsang PCS

Department:

Dental Faculty

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

02/2005

 

Abstract:

Purpose: To investigate the effects of HAART on the oral health of HIV-infected individuals in Hong Kong. Key issues: Before the introduction of HAART in the management of HIV-infected individuals, opportunistic infections were common in this patient group. With the increasing use of HAART, which usually includes a protease inhibitor, the incidence of opportunistic infection has markedly decreased. Though a number of hypotheses had been proposed to explain this phenomenon, the actual mechanism is still unknown. Evidence is there that HAART exerts its effect by increasing the circulating CD4+ T cells, cellular and/or humoral responses. However, some surmise that protease inhibitors may have a direct anti-candidal effect, targeting the secreted aspartyl proteinases (Saps), an essential virulence attribute for mucosal infestation by C. albicans. The major aims of the study are; 1. To obtain data on the incidence and prevalence of oral manifestations of HIV infection by a prospective screening programme of 60 patients under HAART with regards to their oral health. Once these parameters are noted they would be correlated with immunological indices such as CD4+ T cells count and viral load. (Hypothesis: there is a decrease in the prevalence and incidence of oral manifestations of HIV-infected individual under HAART) 2. To study the oral yeast using ‘concentrated oral rinse cultures’ to determine how the use of HAART with and without protease inhibitors can affect the oral carriage rates of Candida species in HIV-infected individuals. (Hypothesis: the oral carriage rate of C. albicans in HIV-infected individuals is decreased by the use of protease inhibitors) 3. To determine C. albicans SAP1 SAP8 gene expression during oral infection and colonization in vivo and the effects of different protease inhibitors on the C. albicans SAP1 SAP8 gene expression. Results thus obtained may assist in the choice and dosage of protease inhibitors when treating these patients. (Hypothesis: SAP gene family are temporally regulated and expressed during candidal infection) 4. To determine the effects of different protease inhibitors on the adherence of C.albicans to buccal epithelial cells, which allow us to have a better understanding in the pathogenesis of oral candidal infection in HIV infection. (Hypothesis: Adherence of C. albicans to buccal epithelial cells is decreased by the presence of protease inhibitors) 5. Finally, the above data is to be collated to produce recommendations, which will improve the maintenance of oral health and hence the general health of HIV-infected individuals in Hong Kong. We are confident that the proposed studies could be successfully completed due to the expertise of the investigators. As far as we are aware, the proposed studies are pioneering investigations on HIV-infections in the South-East Asian region. Hence the data from the study should be of value not only for Hong Kong but also for the South East Asia for investigators in this field. Pending the outcome of the proposed studies, it is our intention to initiate collaborative studies with oral microbiologists and pathologists in neighbouring Asian countries.

 

Project Title:

Effect of different protease inhibitors on Candida albicans SAP1- SAP10 gene expression.

Investigator(s):

Tsang PCS, McMillan AS

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2006

 

Abstract:

Purpose: To investigate the effects of Highly Active Antiretroviral Therapy (HAART) on C. albicans SAP-SAP gene expression in the presence of protease inhibitors. Key issues: Before the introduction of HAART in the management of HIV-infected individuals, opportunistic infections were common in this patient group. With the increasing use of HAART, which usually includes a protease inhibitor, the incidence of opportunistic infection has markedly decreased. Though a number of hypotheses had been proposed to explain this phenomenon, the actual mechanism is still unknown. Evidence is there that HAART exerts its effect by increasing circulating CD4+ T cells, cellular and/or humoral responses. However, some surmise that protease inhibitors may have a direct anti-candidal effect, targeting the secreted aspartyl proteinases (Saps), an essential virulence attribute for mucosal infestation by C. albicans. The major aims of the study are: 1. To determine C. albicans SAP1 SAP10 gene expression during oral infection and colonization in vitro , 2. To determin the effects of different protease inhibitors on the C. albicans SAP1- SAP10 gene expression. Results thus obtained may assist in the choice and dosage of protease inhibitors when treating these patients. (Hypothesis: SAP gene family are temporally regulated and expressed during candidal infection)

 

List of Research Outputs

 

McMillan A.S., Tsang P.C.S., Wong M.C.M. and Kam Y.L., Efficacy of a novel lubricating system in the management of radiotherapy-related xerostomia, Oral Oncology. 2006, 42(8): 842-8.

 

Tsang P.C.S., Ng H. and McMillan A.S., Antifungal susceptibility of Candida albicans biofilms on titanium discs with different surface roughness, Clinical Oral Investigations. 2007, Epub ahead of print.

 

Tsang P.C.S., Ng H. and McMillan A.S., SEM study of candidal-biofilms on titanium with different surface roughness, 84th General Session & Exhibition of the IADR 2006.. 2006.

 

Yip H.K., Tsang P.C.S., Samaranayake L.P. and Li A.H.P., Knowledge of and attitudes toward severe acute respiratory syndrome among a cohort of dental patients in Hong Kong following a major local outbreak, Community Dental Health. 2007, 24: 43-48.

 

Researcher : Wat PYP

List of Research Outputs

 

Wat P.Y.P., Chow K.F., Chu F.C.S. and Chow T.W., Modified mandibular complete denture as an interim implant-supported, cement-retained prosthesis: A clinical technique, Clinical Implant Dentistry and Related Research. 2007, 9: 1-5.

 

Researcher : Wong AHH

List of Research Outputs

 

Lo E.C.M., Wong A.H.H., Chu C.H. and Lin H.C., ART restoration and silver fluoride treatment for decayed primary molars, Journal of Dental Research. 2007, 86 (Spec Iss A): 2772.

 

Wong A.H.H., Cheung C.S. and McGrath C.P.J., Developing a short form of Oral Health Impact Profile (OHIP) for dental aesthetics: OHIP-aesthetic, Community Dentistry and Oral Epidemiology. 2007, 35: 64-72.

 

Researcher : Wong ATY

List of Research Outputs

 

Wong A.T.Y., McMillan A.S. and McGrath C.P.J., Oral health-related quality of life and severe hypodontia, Journal of Oral Rehabilitation. 2006, 33: 869-873.

 

Researcher : Wong CM

Project Title:

Chronic Oro-facial Pain and Need for Treatment among Older Chinese Adults

Investigator(s):

Wong MCM, McMillan AS

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2005

 

Abstract:

The aim of this study is to investigate chronic oro-facial pain and need for treatment among older Chinese adults in Hong Kong.Objectives: 1) to study the severity of chronic oro-facial pain, the disability related to and treatment seeking behaviour for the condition among older Chinese adults and; 2) to study associations and disparities between the severity of chronic oro-facial pain, disability and treatment seeking .Chronic pain is a common and disabling condition, with a high impact on health and the health services in the community (Smith et al. 2001). According to the International Association for the Study of Pain (IASP), chronic pain is defined as pain that persists beyond normal tissue healing time, which in the absence of any other rigorous criteria, is accepted as three months (IASP, 1986). Oro-facial pain can be defined as pain related to the face and/or mouth. Many of these regional pains present a recurrent, persistent, and disabling pattern because of the complex regional anatomy of the face and mouth region, and there are often difficulties in the diagnosis and treatment of chronic oro-facial pain conditions (Chung et al. 2004). The average life expectancy has increased because of the great social and medical achievements, and the proportion of the aged in the population is increasing rapidly in most developed countries including Hong Kong. Degenerative changes in the oro-facial tissue and oro-facial pain are cumulative across the life span, which means that disability and chronic pain are generally maximized among the elderly. Older adults may be vulnerable to chronic oro-facial pain because of the aging process, their oral health status, and social circumstances. The elderly are frequently socially disadvantaged, and pain symptoms in general are more prevalent in those people least able to seek care and attention (Riley et al, 2002). In addition, a key feature of chronic oro-facial pain conditions is that individuals with the same chronic oro-facial pain may respond differently in their need for treatment and ability and desire to obtain professional advice. Thus it is very important to understand the associations and disparities between chronic oro-facial pain and treatment seeking behaviour.Chung JW, Kim JH, Kim JD et al. (2004). Chronic orofacial pain among Korean elders: prevalence, and impact using the graded chronic pain scale. Pain 112:164-170.International Association for the Study of Pain (1986). Classification of chronic pain. Pain (Suppl. 3):S1-S226.Riley JL, Gilbert GH, Heft MW. Race/ethnic differences in health care use for orofacial pain among older adults. Pain 2002;100:119-130.Smith BH, Penny KI, Elliott AM et al. (2001). The Level of Expressed Need - a measure of help-seeking behaviour for chronic pain in the community. European Journal of Pain 5:257-266.

 

Project Title:

Expectation of oral health among older Chinese adults in Hong Kong

Investigator(s):

Wong MCM, Lo ECM, McGrath CPJ

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2006

 

Abstract:

Studies on the relationship between people's expectation and their behaviour have been carried out for many years in psychology but little has been done in dentistry. The decision about whether one needed dental treatment could possibly be affected by the extent of dental problems they expected to encounter and whether they perceive a better oral health-related quality of life (OHQoL) after the treatment. Therefore, the expectation of oral health and OHQoL before dental treatment can be an important factor in determining the perceived need for dental treatment. The aim of this study is to explore, develop and evaluate the performance of a measure of oral health expectation among older Chinese adults in Hong Kong. Objectives: 1) To develope a geriatric oral health expectation index (GOHEI) and 2) To evaluate the performance of GOHEI in terms of feasibility, validity and reliability.

 

Researcher : Wong H-M

List of Research Outputs

 

Wong H.-.M., McGrath C.P.J., Lo E.C.M. and King N.M., Association between developmental defects of enamel and different concentrations of fluoride in the puiblic water supply, Caries Research. 2006, 40: 481-486.

 

Wong H.-.M. and King N.M., More milk, stronger teeth? (Part I) , Dental Asia. 2006, July/August issue: 17-21.

 

Researcher : Wong HM

List of Research Outputs

 

King N.M., Wong H.M. and Kumar V.L.N., Doxycycline: Are its 'side-effects' a contra-indication to its use?, Hong Kong Journal of Paediatrics. 2007, 12(2): 105-110.

 

King N.M., Wong H.M., Almandaey A.H., Dhanpal P.K. and Ekambaram M., More Milk , stronger teeth. (Part III) , Dental Asia. 2007, March/April: 12-16.

 

King N.M., Wong H.M., Almandaey A.H., Dhanpal P.K. and Ekambaram M., More milk, stronger teeth? - Part 2, Dental Asia. 2006, November/December: 23-27.

 

King N.M. and Wong H.M., More milk, stronger teeth? - Part I, Dental Asia . 2006, July/August: 17-21.

 

Tongkoom S., Wong H.M., King N.M. and Cheong H.L., Prevalence and inter-relationship of dental anomalies and traits , International Journal of Paediatric Dentistry. 2007, 17 - Suppl.1: 164.

 

Wong H.M., McGrath C.P.J. and King N.M., Dental practitioners' views on the need to treat developmental defects of enamel, Community Dentistry and Oral Epidemiology. 2007, 35: 130-139.

 

Researcher : Wong MCM

Project Title:

Chronic Oro-facial Pain and Need for Treatment among Older Chinese Adults

Investigator(s):

Wong MCM, McMillan AS

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2005

 

Abstract:

The aim of this study is to investigate chronic oro-facial pain and need for treatment among older Chinese adults in Hong Kong.Objectives: 1) to study the severity of chronic oro-facial pain, the disability related to and treatment seeking behaviour for the condition among older Chinese adults and; 2) to study associations and disparities between the severity of chronic oro-facial pain, disability and treatment seeking .Chronic pain is a common and disabling condition, with a high impact on health and the health services in the community (Smith et al. 2001). According to the International Association for the Study of Pain (IASP), chronic pain is defined as pain that persists beyond normal tissue healing time, which in the absence of any other rigorous criteria, is accepted as three months (IASP, 1986). Oro-facial pain can be defined as pain related to the face and/or mouth. Many of these regional pains present a recurrent, persistent, and disabling pattern because of the complex regional anatomy of the face and mouth region, and there are often difficulties in the diagnosis and treatment of chronic oro-facial pain conditions (Chung et al. 2004). The average life expectancy has increased because of the great social and medical achievements, and the proportion of the aged in the population is increasing rapidly in most developed countries including Hong Kong. Degenerative changes in the oro-facial tissue and oro-facial pain are cumulative across the life span, which means that disability and chronic pain are generally maximized among the elderly. Older adults may be vulnerable to chronic oro-facial pain because of the aging process, their oral health status, and social circumstances. The elderly are frequently socially disadvantaged, and pain symptoms in general are more prevalent in those people least able to seek care and attention (Riley et al, 2002). In addition, a key feature of chronic oro-facial pain conditions is that individuals with the same chronic oro-facial pain may respond differently in their need for treatment and ability and desire to obtain professional advice. Thus it is very important to understand the associations and disparities between chronic oro-facial pain and treatment seeking behaviour.Chung JW, Kim JH, Kim JD et al. (2004). Chronic orofacial pain among Korean elders: prevalence, and impact using the graded chronic pain scale. Pain 112:164-170.International Association for the Study of Pain (1986). Classification of chronic pain. Pain (Suppl. 3):S1-S226.Riley JL, Gilbert GH, Heft MW. Race/ethnic differences in health care use for orofacial pain among older adults. Pain 2002;100:119-130.Smith BH, Penny KI, Elliott AM et al. (2001). The Level of Expressed Need - a measure of help-seeking behaviour for chronic pain in the community. European Journal of Pain 5:257-266.

 

Project Title:

Expectation of oral health among older Chinese adults in Hong Kong

Investigator(s):

Wong MCM, Lo ECM, McGrath CPJ

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2006

 

Abstract:

Studies on the relationship between people's expectation and their behaviour have been carried out for many years in psychology but little has been done in dentistry. The decision about whether one needed dental treatment could possibly be affected by the extent of dental problems they expected to encounter and whether they perceive a better oral health-related quality of life (OHQoL) after the treatment. Therefore, the expectation of oral health and OHQoL before dental treatment can be an important factor in determining the perceived need for dental treatment. The aim of this study is to explore, develop and evaluate the performance of a measure of oral health expectation among older Chinese adults in Hong Kong. Objectives: 1) To develope a geriatric oral health expectation index (GOHEI) and 2) To evaluate the performance of GOHEI in terms of feasibility, validity and reliability.

 

List of Research Outputs

 

Luo Y., McMillan A.S., Wong M.C.M., Zheng J. and Lam C.L.K., Orofacial pain conditions and impact on quality of life in community-dwelling elderly people in Hong Kong, Journal of Orofacial Pain. 2007, 21: 63-71.

 

McMillan A.S., Leung W.S. and Wong M.C.M., Chronic orofacial pain in southern Chinese people: Prevalence, associated disability and help-seeking behaviour, Society of Oral Physiology. 2007, 25: 30.

 

McMillan A.S., Tsang P.C.S., Wong M.C.M. and Kam Y.L., Efficacy of a novel lubricating system in the management of radiotherapy-related xerostomia, Oral Oncology. 2006, 42(8): 842-8.

 

McMillan A.S., Pow E.H.N., Kwong D.L.W., Wong M.C.M., Sham J.S.T., Leung L.H.T. and Leung W.K., Preservation of quality of life after intensity-modulated radiotherapy for early-stage nasopharyngeal carcinoma: Results of a prospective longitudinal study, Head & Neck. 2006, 28: 712-722.

 

McMillan A.S., Wong M.C.M., Zheng J. and Lam C.L.K., Prevalence of Orofacial Pain and Treatment Seeking in Hong Kong Chinese, Journal of Orofacial Pain. 2006, 20: 218-225.

 

Pow E.H.N., Kwong D.L.W., McMillan A.S., Wong M.C.M., Sham J.S.T., Leung L.H.T. and Leung W.K., Xerostomia and quality of life after intensity-modulated radiotherapy vs. conventional radiotherapy for early-stage nasopharyngeal carcinoma: Initial report on a randomized control clinical trial., International Journal of Radiation Oncology, Biology, Physics. 2006, 66: 981-991.

 

Wong M.C.M., You D.S.H., Choi B.S.K., Hon A.K., Lee A.T.W., Lue J., Lui J.K.L., Ngai S.C., Poon M.S.L. and Siu E.K.S., A survey on the public and dentists' attitudes towards advertising in dentistry in Hong Kong, Community Health Project Report Series. Faculty of Dentistry, The University of Hong Kong, 2007, 147: 1-55.

 

Wong M.C.M., Lam K.F. and Lo E.C.M., Faculty Research Output Prize, 2006.

 

Wong M.C.M., Chen A., Lau K.L., Law C.K., Ng P.C., Tang H.Y. and Wong T.S., Views on DSA continuing education: the dentists' & dental surgery assistants' perspective, Community Health Project Report Series. Faculty of Dentistry, The University of Hong Kong, 2007, 149: 1-40.

 

Researcher : Wong RWK

Project Title:

Bone induction using Naringin

Investigator(s):

Wong RWK, Rabie ABM

Department:

Dental Faculty

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

10/2004

 

Abstract:

To investigate the use of Naringin on bone induction.

 

Project Title:

Cellular and molecular responses of mouse cranial bases (synchondroses) in mechanical stress.

Investigator(s):

Wong RWK, Rabie ABM

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

01/2006

 

Abstract:

To investigate the cellular and molecular responses of mouse craninal bases (synchondroses) in mechanical stress in organ culture.

 

Project Title:

The use of Genistin in bone induction

Investigator(s):

Wong RWK, Rabie ABM

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

01/2007

 

Abstract:

Objective:Bone induction is used to replace bone lost due to trauma, tumours and other pathological diseases. Over the years autogenous cancellous bone grafting has been considered the gold standard in this form of treatment. The major limitations of using autogenous grafting are the inadequacy of supply and surgical morbidity; including donor site pain, paraesthesia, and infection, which can approach 8% to 10% (Younger and Chapman 1989). Moreover, graft resorption poses a severe problem. In an experimental study, endochondral bone grafts showed 65% volume loss (Zins and Whitaker 1983). Allografts, an alternative to autogenous grafting, seem to be biologically inferior and are associated with infection and inflammation (Strong et al. 1996). Therefore, the search of an ideal bone grafting material that induces bone is an important issue in bone research. Bone morphogenetic proteins (BMPs) are important regulators in bone formation (Sakou 1998). Mundy et al. (1999) demonstrated that statin, a hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, specifically increased expression of the BMP-2 gene. We showed that statin increased new bone formation by more than 300% in vivo (Wong and Rabie 2003). Unfortunately, statin also has some side effects, including weakness, headache and on occasion serious muscle problems (Sifton, 2000), making the search for an ideal bone inductive agent still a necessity.Further studies have shown that this BMP-2 activation was a result of enzyme inhibition (Sugiyama et al. 2000). Therefore, it is possible that any drug that inhibits the HMG-CoA reductase may have a similar effect to statin in the activation of BMP-2.Genistin is a flavonoid found in the Chinese Medicine Ge Gen (Puerariae radix), the herb which has been shown to increase bone density (Wang et al. 2003). Our pilot study did shown that Ge Gen extract in a collagen carrier induced bone when grafted in a bone defect in rabbits. It is also commonly found in soybeans and soy foods such as tofu and light sauce. Studies have been made of its estrogenic, anti-osteoporotic, antioxidant, anticarcinogenic and anticholesterol effect. It has also been shown to have a HMG-CoA reductase inhibiting effect (Sung et al. 2004). It is therefore possible that Genistin may also activate BMP-2 and increase bone formation. To examine further the role of Genistin in clinical use for the repair of bone defects, it is important to examine its osteoinductivity in the presence of a carrier and to examine its healing route in an in vivo study.Aims:o To test the hypothesis that Genistin is effective for bone induction.o To examine the ability of Genistin with a carrier in bone induction by quantitatively assessing the amount of new bone formation with and without Genistin. o To identify the action mode and effects of Genistin on the gene expression profile in a Genistin -treated osteoblastic cell line cultured in vitro using molecular biology techniques.

 

List of Research Outputs

 

Alkhal H., Wong R.W.K. and Rabie A.B.M., Poster Presentations: Skeletal age maturation and cervical vertebrae maturation., 20th Annual Scientific Meeting of the Faculty of Dentistry, The University of Hong Kong, 15 December 2006. . 2006.

 

Alkhal H., Wong R.W.K. and Rabie A.B.M., Skeletal maturation and cervical vertebrae, Surgical Practice. 2006, Vol 10, supplement: A99.

 

Alkhal H.A., Wong R.W.K. and Rabie A.B.M., The use of lateral cephalometric radiographs to determine skeletal maturation in Chinese, The Second Cross-Strait Four Regions Orthodontic Conference, Nanjing, China, 19 – 21 November, 2006. . 2006.

 

Alkhal H.A., Wong R.W.K. and Rabie A.B.M., Use of the cervical vertebrae maturation method the growth spurt determination , 83rd Congress of the European Orthodontic Society, Berlin, Germany, 20-24 June. 2007.

 

Bendeus S.A.M., Hagg E.U.O. and Wong R.W.K., Bracing for the future, Faculty Expressions 2006. 2006, 9.

 

Cendekiawan T., Rabie A.B.M. and Wong R.W.K., Oral Presentations - Expression of SOX 9 and type II collagen in the spheno-occipital synchondrosis, 83rd Congress of the European Orthodontic Society, Berlin, Germany, 20-24 June. 2007.

 

Edmad B.A.S.S.E.M., Sherif E.L.-.M.O.F.T.Y., Wong R.W.K., Bendeus S.A.M. and Rabie A.B.M., Vacular Endthelial Growth Factor Augments the Healing of Demineralized Bone Matrix Grafts, International Journal of Surgery. 2006, 4: 160-166.

 

Hou H.M., Hagg E.U.O., Sam K., Rabie A.B.M., Wong R.W.K., Lam B. and Ip M.S.M., Dentofacial Characteristics of Chinese Obstructive Sleep Apnea Patients in Relation to Obesity and Severity, The Angle Orthodontist. 2006, 76 No.6: 962-969.

 

Hou H.M., Wong R.W.K. and Hagg E.U.O., The uses of orthodontic study models in diagnosis and treatment planning , Hong Kong Dental Journal. 2006, Vol. 3 No..2: 107-115.

 

Ikegami T., Wong R.W.K. and Hagg E.U.O., A hybrid orthodontic treatment system, 83rd Congress of the European Orthodontic Society, Berlin, Germany, 20-24 June. 2007.

 

Lee C.K., Rabie A.B.M., Wong R.W.K. and McGrath C.P.J., Poster Presentations: Comparison of pain level in microimplant surgery versus other orthodontic procedures. , 20th Annual Scientific Meeting of the Faculty of Dentistry, The University of Hong Kong, 15 December 2006.. 2006.

 

Lee T.C., Rabie A.B.M., Wong R.W.K. and McGrath C.P.J., Patients perception to microimplant as anchorage in orthodontics , 83rd Congress of the European Orthodontic Society, Berlin, Germany, 20-24 June. 2007.

 

Lee T.C.K., Rabie A.B.M., Wong R.W.K. and McGrath C.P.J., Patients’ Perception To Micro-implant as Anchorage in Orhodontics, The Second Cross-Strait Four Regions Orthodontic Conference, Nanjing, China, 19 – 21 November, 2006. . 2006.

 

Lei W.Y., Rabie A.B.M. and Wong R.W.K., Factors regulating endochondral ossification in spheno-occipital synchondrosis, 83rd Congress of the European Orthodontic Society, Berlin, Germany, 20-24 June. 2007.

 

Leung M.T., Rabie A.B.M. and Wong R.W.K., Stability of connected micro-implants and miniplates for skeletal anchorage, 83rd Congress of the European Orthodontic Society, Berlin, Germany, 20-24 June. 2007.

 

Leung M.T.C., Rabie A.B.M. and Wong R.W.K., Oral Presentation: Stability of connected micro-implants and mini-plates for orthodontic skeletal anchorage. , 20th Annual Scientific Meeting of the Faculty of Dentistry, The University of Hong Kong, 15 December 2006. . 2006.

 

Ling J.Y.K. and Wong R.W.K., Tooth Dimensions of Southern Chinese, Journal of Comparative Human Biology. 2007, 58: 67-73.

 

Ng F.S.A., Hagg E.U.O. and Wong R.W.K., Facial Asymmetry. The Orthodontist's Viewpoint, Dental Asia January/ February 2007 issue. 2007, 19-24.

 

Purkayastha S.K., Rabie A.B.M. and Wong R.W.K., Orthopaedic correction of skeletal class II adult patients, 83rd Congress of the European Orthodontic Society, Berlin, Germany, 20-24 June. 2007.

 

Purkayastha S.K., Rabie A.B.M. and Wong R.W.K., Poster Presentations: Correction of mandibular retrognathism in mature individuals using the herbst appliance. , 20th Annual Scientific Meeting of the Faculty of Dentistry, The University of Hong Kong, 15 December 2006. . 2006.

 

Rabie A.B.M., Wong R.W.K. and King N.M., Aesthetic Dentistry and Orthodontics, The Hong Kong Medical Diary. 2006, Vol. 11 No.8: 7-11.

 

Rabie A.B.M., Hagg E.U.O., Wong R.W.K. and Al K.A.A.A., Indian Hedgehog is a mechanotransduction mediator in mandibular condyles., Biological Mechanisms of Tooth Eruption, Resorption, and Movement - Proceedings of the Eighth International Conference, Phuket, Thailand, 2005. Eds. Davidovitch Z., Mah J. and Suthanarak S., University of South California, School of Dentistry . 2006, 179-189.

 

Rabie A.B.M. and Wong R.W.K., Management of Patients with Severe Bone Loss:Bone Induction and Orthodontics, The Philippine Journal of Orthodontics. 2006, Vol.5 No.1: 1-7.

 

Rukkulchon K., Wong R.W.K. and Rabie A.B.M., Effect of tensile force on the expression of PTHRP in mouse synchondrosis, 83rd Congress of the European Orthodontic Society, Berlin, Germany, 20-24 June. 2007.

 

Song Y., Rabie A.B.M. and Wong R.W.K., Microarray Analysis of Mandibular Condyle under Mechanical Strain , 82nd Congress of the European Orthodontic Society in Vienna, Austria, 4 – 8 July, 2006.. 2006.

 

Tsui V.W., Rabie A.B.M. and Wong R.W.K., A novel antimicrobial agent, 83rd Congress of the European Orthodontic Society, Berlin, Germany, 20-24 June. 2007.

 

Tsui V.W.K., Rabie A.B.M. and Wong R.W.K., Effects of naringin on periodontal pathogens and oral microorganisms, Merit for the Outstanding Oral Presentation (Junior Category). Awarded by the 20th Annual Scientific Meeting of the Faculty of Dentistry, The University of Hong Kong, 15 December, 2006. 2006.

 

Tsui V.W.K., Rabie A.B.M. and Wong R.W.K., Oral Presentation: Effects of naringin on periodontal pathogens and oral microorganisms., 20th Annual Scientific Meeting of the Faculty of Dentistry, The University of Hong Kong, 15 December 2006. . 2006.

 

Tsui V.W.K., Rabie A.B.M. and Wong R.W.K., The Effects of Naringin on the Growth of Periodontal Pathogens in Vitro, The Best Research Paper. Awarded by the Hong Kong Society of Orthodontists at the 2nd Cross Strait 4 Regions Orthodontics Conference, Nanjing, China, 12 December, 2006. 2006.

 

Tsui V.W.K., Rabie A.B.M. and Wong R.W.K., The effects of naringin on the growth of periodontal pathogens in vitro’, The Second Cross-Strait Four Regions Orthodontic Conference, Nanjing, China, 19 – 21 November, 2006. . 2006.

 

Wong R.W.K. and Rabie A.B.M., Bone formation using puerarin graft., 20th Annual Scientific Meeting of the Faculty of Dentistry, The University of Hong Kong, 15 December 2006. . 2006.

 

Wong R.W.K. and Rabie A.B.M., Bone induction using puerarin, 83rd Congress of the European Orthodontic Society, Berlin, Germany, 20-24 June. 2007.

 

Wong R.W.K., Alkhal H. and Rabie A.B.M., Cervical Vertebra Maturation in Southern Chinese Subjects , 82nd Congress of the European Orthodontic Society in Vienna, Austria, 4 – 8 July, 2006.. 2006.

 

Wong R.W.K., Chairman of Session, 20th Annual Scientific Meeting of the Faculty of Dentistry. 15th December, 2006; The Prince Philip Dental Hospital.. 2006.

 

Wong R.W.K. and Rabie A.B.M., Effect of a phytoestrogen graft on bone formation, Surgical Practice. 2006, Vol 10, suppliment: A6.

 

Wong R.W.K. and Rabie A.B.M., Effect of a phytoestrogen graft on bone formation, The Best Scientific Paper in Dentistry/OMFS. Awarded by the RCSED/CSHK Conjoint Scientific Congress in October 2006 . 2006.

 

Wong R.W.K. and Rabie A.B.M., Effect of puerarin on bone formation , Osteoarthritis and Cartilage. 2007, 15: 894-899.

 

Wong R.W.K., Grapefruit Forms Bone?, Apple Daily . 2006.

 

Wong R.W.K., Grapefruit Forms Bone?, Hong Kong Economy Daily. 2006.

 

Wong R.W.K., Grapefruit Forms Bone?, Ming Pao Daily. 2006.

 

Wong R.W.K., Grapefruit Forms Bone?, Sing Tao Daily. 2006.

 

Wong R.W.K. and Rabie A.B.M., HMGCo-A Reductase Inhibitors increase Bone Formation, 82nd Congress of the European Orthodontic Society in Vienna, Austria, 4 – 8 July, 2006. . 2006.

 

Wong R.W.K. and Rabie A.B.M., Invited speaker 'Phytochemicals for bone formation', The second Cross-Strait Four Regions Orthodontic Conference, Nanjing, China, 19 - 21 November, . 2006.

 

Wong R.W.K., Method for Orthodontics Treatment, Ming Pao Weekly, 27 October, 2006. 2006.

 

Wong R.W.K. and Rabie A.B.M., Osteogenic Effect of Puerarin , MGH-HKU-Nature China Forum, Cheung Kung Hai Conference Centre, Li Ka Shing Faculty of Medicine, The University of Hong Kong Osteogenic. March 5-6, 2007 . 2007.

 

Wong R.W.K., Poster presentation:HMGCo- A Reductase Inhibitors Increase Bone Formation. , 85th General Session & Exhibition of the IADR, International Association for Dental Research, New Orleans, USA, March 21 – 24, 2007.

 

Wong R.W.K. and Rabie A.B.M., Recent Developments on Plant Extracts for bone induction, Recent Developments in Medicinal Plant Research. Research Signpost, Kerala, India.. 2007, Chapter 6: 99-120.

 

Wong R.W.K., Supporting in developing the new exhibition 'Grapefruit Forms Bone?' for Science News Corner, Hong Kong Science Museum, Leisure and Cultural Services Department. 2006.

 

Wong R.W.K., Ten Years of Research on Bond Induction , Oral Health and Science Seminars. The Prince Philip Dental Hospital, Faculty of Dentistry, University of Hong Kong, 24 January, 2007.. 2007.

 

Wong R.W.K., Rabie A.B.M. and Hagg E.U.O., The Effect of Crude Extract from Radix Dipsaci on Bone in Mice, Phytotherapy Research. 2007, 21: 596-598.

 

Wong R.W.K., Shum L.M.Y. and Hagg E.U.O., The Gold Medal of the Conjoint M.Orth Examination of the Royal College of Surgeons of Edinburgh, Surgical Orthodontic Cases., Journal of Orthodontic. 2006, 33: 172-184.

 

Wong R.W.K., The Important of Chewing Food , Press Interview – Sing Tao Daily. 2007.

 

Wong R.W.K., The Use of Lateral Cephalometric Radiographs on Maturity Assessment, Oral Health and Science Seminars . 2007.

 

Wong R.W.K. and Rabie A.B.M., ‘Phytochemicals for bone formation, The Second Cross-Strait Four Regions Orthodontic Conference, Nanjing, China, 19 – 21 November, 2006. . 2006.

 

Researcher : Wong WS

List of Research Outputs

 

Yip H.K., Guo J. and Wong W.S., Incipient caries lesions on cementum by mono- and co-culture oral biofilms, Journal of Dentistry. 2007, 35: 377-382.

 

Researcher : Wu CT

List of Research Outputs

 

Wu C.T. and Darvell B.W., Necessity of benzoyl peroxide for heat-processed denture-base acrylic, 85th General Session & Exhibition of the IADR, New Orleans, Louisiana, USA, 21-24 March 2007. abstract 1600.

 

Researcher : Wu HF

List of Research Outputs

 

Wu H.F., Luk K.C., Liang B.M.H., Chen Y.M., Yip H.K. and Smales R.J., Mathematical analysis of occlusal rest design for cast removable partial dentures , European Journalof Prosthodontics. 2007, 15: 29-32.

 

Researcher : Xiao Y

List of Research Outputs

 

Chu C.H. and Xiao Y., Dental practice licensing examination in Mainland China, Hong Kong Dental Journal. 2006, 3: 137-138.

 

Researcher : Yau JYY

List of Research Outputs

 

Dassanayake R.S., Samaranayake Y.H., Yau J.Y.Y. and Samaranayake L.P., DNA fingerprinting elecited evolutionary trend of oral candida tropicalis isolates from diverse geographic locales , Indian Journal of Medical Microbiology. 2006, 24(3): 186-94.

 

Samaranayake Y.H., Dassanayake R.S., Cheung B.P.K., Jayatilake J.A.M.S., Yeung S.K.W., Yau J.Y.Y. and Samaranayake L.P., Differential phospholipase gene expression by Candida albicans in artificial media and cultured human oral epithelium, APMIS. 2006, 114: 857-66.

 

Samaranayake Y.H., Samaranayake L.P., Cheung B.P.K., Parahitiyawa N.B., Yau J.Y.Y. and Yeung S.K.W., Inhibitory Effect of Lysozyme and antifungals against Candida albicans biofilms, Journal of Dental Research. New Orleans March 21-24, 85th General Session & Exhibition of the IADR, 2007, 86: Special Issue A.

 

Researcher : Yeung RWK

Project Title:

Prospective study on arthrocentesis

Investigator(s):

Yeung RWK, Cheung LK

Department:

Dental Faculty

Source(s) of Funding:

Low Budget High Impact Programme

Start Date:

11/2001

 

Abstract:

To determine the short and long term benefit of TMJ arthrocentesis in closed locking joints; to compare the sodium hyaluronate and steriod and normal saline in TMJ arthrocentesis; to determine the intraarticular joint pressure during closed lock and the pressure changes following treatment; to determine the biochemical markers in the closed lock joints - e.g. cytokines.

 

List of Research Outputs

 

Yeung R.W.K., Samman N. and Xia J.J., Image-guided minimally invasive surgical access to the temporomandibular joint: a preliminary report, Journal of Oral and Maxillofacial Surgery. 2006, 64: 1546-1552.

 

Yeung R.W.K., Samman N., Chow R.L.K. and Chiu W.K., Short-term therapeutic outcome of intra-articular high molecular weight hyaluronic acid injection for non-reducing disc displacement of the temporomandibular joint, Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology & Endodontics. 2006, 102 (4): p. 453-461.

 

Yeung R.W.K., Samman N., Cheung L.K., Zhang C...P... and Chow R.L.K., Stereomodel-assisted fibula flap harvest and mandibular reconstruction, Journal of Oral and Maxillofacial Surgery. 2007, 65: p.1128-1134.

 

Researcher : Yeung SKW

List of Research Outputs

 

Samaranayake Y.H., Dassanayake R.S., Cheung B.P.K., Jayatilake J.A.M.S., Yeung S.K.W., Yau J.Y.Y. and Samaranayake L.P., Differential phospholipase gene expression by Candida albicans in artificial media and cultured human oral epithelium, APMIS. 2006, 114: 857-66.

 

Samaranayake Y.H., Samaranayake L.P., Cheung B.P.K., Parahitiyawa N.B., Yau J.Y.Y. and Yeung S.K.W., Inhibitory Effect of Lysozyme and antifungals against Candida albicans biofilms, Journal of Dental Research. New Orleans March 21-24, 85th General Session & Exhibition of the IADR, 2007, 86: Special Issue A.

 

Researcher : Yip HK

Project Title:

The effects of bacteria derived endotoxin on osteogenic and neurogenic differentiation of bone marrow derived stem cells

Investigator(s):

Yip HK, Chan GCF

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

 

Abstract:

To evaluate the effect of endotoxin on the osteogenic differentiation of human bone marrow derived mesenchymal stem cells (MSCs).

 

Project Title:

Influence of Different Surface Treatment of Titanium on the Osteogenic Proliferation of Human Mesenchyamal Stem Cells.

Investigator(s):

Yip HK

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

09/2005

 

Abstract:

To evaluate the effect of different surface of titanium on the osteogenic differentiation of human bone marrow derived mesenchymal stem cells (MSCs).

 

Project Title:

Local delivery of hMSCs and re-constituted collagen for rapid bone regeneration.

Investigator(s):

Yip HK, Chan GCF, Chan BP, Chan D

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

09/2006

 

Abstract:

Implant dentistry has been successfully practised for over two decades and its efficacy is proven by long-term clinical trials (Esposito et al., 2005). But problems remain such as the loss of alveolar bone and supportive structures in edentulous areas or loosening of the implant due to suboptimal integration of the implant with the supporting structures. The use of multipotential stem cells to improve the formation of supportive structures is therefore a very appealing approach. Stem cell based composite with collagen scaffolds is becoming a critical part in the bone generation and osseointegration process after the implant surgery.

 

List of Research Outputs

 

Komabayashi T., Kawamura M., Kim K.-.J., Wright F.A.C., Declerck D., Freire M.D.C.M.F., Hu D.-.Y., Honkala E., Lévy G., Kalwitzki M., Polychronopoulou A., Yip H.K., Kinirons M.J., Eli I., Petti S., Srisilapanan P., Kwan S.Y.L. and Centore L.S., The hierarchical cluster analysis of oral health attitudes and behaviour using the Hiroshima University - dental behavioural inventory (HU-DBI) among final year dental students in 17 countries, International Dental Journal. 2006, 56(5): 310-316.

 

Liang B.M.H., Chen Y.-.M., Wu X., Yip H.K. and Smales R.J., Fracture resistance of roots with thin walls restored using an intermediate resin compsite layer placed between the dentine and a cast metal post, European Journal of Prosthodontics. 2007, 15: 19-22.

 

Mo F.Y., Yip H.K., Law H.K.W., Lau Y.L. and Chan G.C.F., Effects of bacterial toxins on the growth, differentiation and toll-like receptor genes of human mesenchymal stem cells, Cytokine 2006. 17: 120.

 

Wu H.F., Luk K.C., Liang B.M.H., Chen Y.M., Yip H.K. and Smales R.J., Mathematical analysis of occlusal rest design for cast removable partial dentures , European Journalof Prosthodontics. 2007, 15: 29-32.

 

Wu X., Chan A.T.T., Chen Y.-.M., Yip H.K. and Smales R.J., Fracture resistance of thin-walled roots reinforced by two materials, Dental Materials. 2007, 23: 479-485.

 

Yip H.K., Guo J.H. and Wong W.H.S., Human root surface with mono-, bi- and tri-species cariogenic oral biofilm, International Dental Journal, FDI 2006, September 22-26,Shen Zhen, China. 2006, abstract #: pp184.

 

Yip H.K., Guo J.H. and Wong W.H.S., Incipient caries lesions on cementum by mono- and co-culture oral bacteria, Journal of Dentistry. Elsevier Ltd., 2007, 35: 377-382.

 

Yip H.K., Guo J. and Wong W.S., Incipient caries lesions on cementum by mono- and co-culture oral biofilms, Journal of Dentistry. 2007, 35: 377-382.

 

Yip H.K., Tsang P.C.S., Samaranayake L.P. and Li A.H.P., Knowledge of and attitudes toward severe acute respiratory syndrome among a cohort of dental patients in Hong Kong following a major local outbreak, Community Dental Health. 2007, 24: 43-48.

 

Yip H.K., Zhang T. and Fang H.F.F., Microbiota of high and low caries risk oral biofilm, 4th Biofilm Conference of American Society of Microbiology, Montreal, Quebec, Canada, March 25-29, 2007, confirmation # 462. 2007.

 

Yip H.K., Zhang T. and Fang H.F.F., Oral biofilms from high and low caries risk patients, IADR/AADR/CADR 85th General Session and Exhibition, New Orleans, USA on March 21-24, 2007.

 

Yip H.K., Guo J. and Wong W.H.S., Protection Offered by Root-surface Restorative Materials against Biofilm Challenge, Journal of Dental Research. 2007, 86(5): 431-435.

 

Yip H.K., Guo J. and Wong W.H.S., Protection offered by root surface restoratives against biofilm challenge, Journal of Dental Research. 2007, 86: 431-435.

 

Researcher : Yiu CKY

List of Research Outputs

 

Chung C.W.M., Anthonappa R.P., Yiu C.K.Y. and King N.M., Concomitant occurrence of hypodontia and supernumerary teeth in two children , International Journal of Paediatric Dentistry. 2007, 17: P.69.

 

Dhanpal P.K., Anthonappa R.P., Yiu C.K.Y. and King N.M., Dens evaginatus and dens invaginatus in a single tooth, International Journal of Paediatric Dentistry. 2007, 17: P.70.

 

Hiraishi N., Yiu C.K.Y. and King N.M., Bonding strength on dentin from primary tooth with amelogenesis imperfecta, International Journal of Paediatric Dentistry. 2007, 17: P.17.

 

Itthagarun A., King N.M. and Yiu C.K.Y., Paediatric Dentistry in Hong Kong, Expressions (Newsletter of the HKU Faculty of Dentistry). 2007, Issue 1: 11.

 

Malacarne J., Carvalho R.M., de Goes M.F., Svizero N., Pashley D.H., Tay F.R., Yiu C.K.Y. and Carrilho M.R., Water sorption/solubility of dental adhesive resins., Dental Materials. 2006, 22: 973-980.

 

Manikandan E., Yiu C.K.Y. and King N.M., Double teeth with facial and lingual talon cusps, International Journal of Paediatric Dentistry . 2007, 17: P.69-70.

 

Peerzada F., Anthonappa R.P., Yiu C.K.Y. and King N.M., Congenitally missing first permanent molars: a case report, International Journal of Paediatric Dentistry . 2007, 17: P.69.

 

Yiu C.K.Y., An update on dentine bonding agents, The Royal Australasian College of Dental Surgeons Asian Reginal Committee. 2007.

 

Yiu C.K.Y., Hiraishi N. and King N.M., Bond strength of self-etch adhesives to bur-cut dentin, International Journal of Paediatric Dentistry. 2007, 17: P.18.

 

Yiu C.K.Y., Dental Management of Special Needs Children, School Dental Care Service, Department of Health, Hong Kong. 2006.

 

Yiu C.K.Y., Dentin hard tissues and bonding: interfacial phenomena and related properties, Expressions (Newsletter of the HKU Faculty of Dentistry). 2006, 3: 15.

 

Yiu C.K.Y., Hiraishi N. and King N.M., Effect of dentinal surface preparation on bond strength of self-etch adhesives, 20th Annual Scientific Meeting of the Faculty of Dentistry, Faculty of Dentistry, The Universlity of Hong Kong. 2006.

 

Yiu C.K.Y., Fluid transport across bonded dentin interfaces, PhD Thesis. The University of Hong Kong, 2006.

 

Yiu C.K.Y., King N.M. and Itthagarun A., Good beginnings, Expressions (Newsletter of the HKU Faculty of Dentistry). 2007, Issue 1: 11.

 

Researcher : You DSH

List of Research Outputs

 

Wong M.C.M., You D.S.H., Choi B.S.K., Hon A.K., Lee A.T.W., Lue J., Lui J.K.L., Ngai S.C., Poon M.S.L. and Siu E.K.S., A survey on the public and dentists' attitudes towards advertising in dentistry in Hong Kong, Community Health Project Report Series. Faculty of Dentistry, The University of Hong Kong, 2007, 147: 1-55.

 

Researcher : Zaw MT

List of Research Outputs

 

Zaw M.T., Samaranayake Y.H. and Samaranayake L.P., Effect of oral bacteria on growth and survival of Candida albicans biofilms, Archives of Oral Biology. 2006, 51: 672-680.

 

Zaw M.T., Samaranayake Y.H. and Samaranayake L.P., In vitro biofilm formation of Candida albicans and non-albicans Candida species under dynamic and anaerobic conditions, Archives of Oral Biology. Elsevier, 2007, 52: 761-767.

 

Researcher : Zee KY

Project Title:

Alveolar bone changes and bacterial profiles around osseointegrated dental implants in smoker and non-smoker

Investigator(s):

Zee KY

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

Completion Date:

10/2006

 

Abstract:

To compare the alveolar bone changes and microbial profile of single implant in smoker and non-smoker during the 6-week healing period and after functional loading for 3 years.

 

List of Research Outputs

 

Zee K.Y., Lee D.H. and Corbet E.F., Repeated oral hygiene instructions alone, or in combination with metronidazole dental gel with or without subgingival scaling in adult periodontitis patients: A one-year clinical study, Journal of the International Academy of Periodontology. 2006, 8: 125-135.

 

Researcher : Zhang M

List of Research Outputs

 

Zhang M., McGrath C.P.J. and Hagg E.U.O., Patients' expectations and experiences of fixed orthodontic appliance therapy, Angle Orthodontist. 2007, 77: 318-322.

 

Zhang M., McGrath C.P.J. and Hagg E.U.O., The impact of malocclusion and its treatment on quality of life: a literature review, International Journal of Paediatric Dentistry. 2006, 16: 381-387.

 

Zhang M., McGrath C.P.J. and Hagg E.U.O., Who knows more about the impact of malocclusion on children's quality of life, mothers or fathers?, European Journal of Orthodontics. 2007, 29: 180-185.

 

Researcher : Zheng J

List of Research Outputs

 

Luo Y., McMillan A.S., Wong M.C.M., Zheng J. and Lam C.L.K., Orofacial pain conditions and impact on quality of life in community-dwelling elderly people in Hong Kong, Journal of Orofacial Pain. 2007, 21: 63-71.

 

McMillan A.S., Wong M.C.M., Zheng J. and Lam C.L.K., Prevalence of Orofacial Pain and Treatment Seeking in Hong Kong Chinese, Journal of Orofacial Pain. 2006, 20: 218-225.

 

Researcher : Zheng L

List of Research Outputs

 

Cheung L.K. and Zheng L., Biochemical modulation of distraction osteogenesis by growth factors in jaw lengthening, 4th Tissue Engineering Symposium. 2007, p. 3.

 

Cheung L.K., Zheng L. and Ma L., Effect of distraction rates on expression of bone morphogenetic proteins in rabbit mandibular distraction osteogenesis, Journal of Cranio-maxillofacial Surgery. 2006, 34: 263-9.

 

Cheung L.K., Shi X. and Zheng L., Surgical induction of temporomandibular joint ankylosis: an animal model, Journal of Oral and Maxillofacial Surgery. 2007, 65: p. 993-1004.

 

Cheung L.K., Ma L. and Zheng L., Tissue engineering for mandibular bone lengthening in smokers. , Europen Cell and Materials . 2007, 13: 9.

 

Cheung L.K., Ma L. and Zheng L., Tissue engineering for mandibular bone lengthening in smokers, International Biotechnology Symposium on "From Basic Research to Clinical Applications using Biotechnology and Bioengineering". 2006, p.36.

 

Ma L., Zheng L. and Cheung L.K., Effect of nicotine on bone regeneration in mandibular distractin osteogenesis, Transactions of 3rd Asia Pacific Congress on Craniofacial Surgery & Distraction Osteogenesis. 2007, p. 259-271.

 

Ma L., Zheng L. and Cheung L.K., Inhibitory effect of nicotine on bone regeneration in mandibular distraction osteogenesis, Frontiers in Bioscience. 2007, 12: 3256-62.

 

Zheng L. and Cheung L.K., Biochemical and mechanical modulation of distraction osteogenesis (Winner of Dean's award for the Best Oral Presentation - Senior Category), 20th Annual Scientific Meeting, Faculty of Dentistry, The University of Hong Kong. 2006, p. 22.

 

Zheng L., Ma L. and Cheung L.K., Effect of nicotine on expression of bone morphogenetic protein-2 in rabbit mandibular distraction osteogenesis, 4th Tissue Engineering Symposium. 2007, p. 64.

 

Zheng L., Ma L. and Cheung L.K., Effect of nicotine on mandibular distraction osteogenesis: a radiological and immunohistochemical study, Europen Cell and Materials. 2007, 13: 54.

 

Zheng L., Ma L. and Cheung L.K., Effect of nicotine on mandibular distraction osteogenesis: a radiological and immunohistochemical study, International Biotechnology Symposium on "From Basic Research to Clinical Applications using Biotechnology and Bioengineering". 2006, Poster 04.

 

Zheng L. and Cheung L.K., Effect of recombinant human bone morphogenetic protein-2 on mandibular distraction at different rates in a rabbit model, Asian J Oral Maxillofac Surg. 2006, 18:3 (Suppl 1): p.63.

 

Zheng L. and Cheung L.K., Effect of recombinant human bone morphogenetic protein-2 on mandibular distraction at different rates in a rabbit model, Tissue Engineering. 2006, 12: 3181-3188.

 

Zheng L. and Cheung L.K., Effect of recombinant human tissue inhibitor of matrix metalloproteinase-1 in rabbit mandibular distraction osteogenesis, 4th Tissue Engineering Symposium. 2007, p. 23.

 

Zheng L., Ma L. and Cheung L.K., Effect of recombinant human tissue inhibitor of matrix metalloproteinase-1 in rabbit mandibular distraction osteogenesis: a histological and immunohistochemical study, Journal of Cranio-maxillofacial Surgery. 2006, 34: 277-82.

 

Zheng L., Effect of rhBMP-2 on mandibular distraction osteogenesis, Transactions of 3rd Asia Pacific Congress on Craniofacial Surgery & Distraction osteogenesi. 2007, p187.

 

Zheng L., Surgical and biological approach for bone regeneration, Scientific Seminar in School of Stomatology, Wuhan University. 2007.

 

Researcher : Zheng L

List of Research Outputs

 

Cheung L.K. and Zheng L., Biochemical modulation of distraction osteogenesis by growth factors in jaw lengthening, 4th Tissue Engineering Symposium. 2007, p. 3.

 

Cheung L.K., Zheng L. and Ma L., Effect of distraction rates on expression of bone morphogenetic proteins in rabbit mandibular distraction osteogenesis, Journal of Cranio-maxillofacial Surgery. 2006, 34: 263-9.

 

Cheung L.K., Shi X. and Zheng L., Surgical induction of temporomandibular joint ankylosis: an animal model, Journal of Oral and Maxillofacial Surgery. 2007, 65: p. 993-1004.

 

Cheung L.K., Ma L. and Zheng L., Tissue engineering for mandibular bone lengthening in smokers. , Europen Cell and Materials . 2007, 13: 9.

 

Cheung L.K., Ma L. and Zheng L., Tissue engineering for mandibular bone lengthening in smokers, International Biotechnology Symposium on "From Basic Research to Clinical Applications using Biotechnology and Bioengineering". 2006, p.36.

 

Ma L., Zheng L. and Cheung L.K., Effect of nicotine on bone regeneration in mandibular distractin osteogenesis, Transactions of 3rd Asia Pacific Congress on Craniofacial Surgery & Distraction Osteogenesis. 2007, p. 259-271.

 

Ma L., Zheng L. and Cheung L.K., Inhibitory effect of nicotine on bone regeneration in mandibular distraction osteogenesis, Frontiers in Bioscience. 2007, 12: 3256-62.

 

Zheng L. and Cheung L.K., Biochemical and mechanical modulation of distraction osteogenesis (Winner of Dean's award for the Best Oral Presentation - Senior Category), 20th Annual Scientific Meeting, Faculty of Dentistry, The University of Hong Kong. 2006, p. 22.

 

Zheng L., Ma L. and Cheung L.K., Effect of nicotine on expression of bone morphogenetic protein-2 in rabbit mandibular distraction osteogenesis, 4th Tissue Engineering Symposium. 2007, p. 64.

 

Zheng L., Ma L. and Cheung L.K., Effect of nicotine on mandibular distraction osteogenesis: a radiological and immunohistochemical study, Europen Cell and Materials. 2007, 13: 54.

 

Zheng L., Ma L. and Cheung L.K., Effect of nicotine on mandibular distraction osteogenesis: a radiological and immunohistochemical study, International Biotechnology Symposium on "From Basic Research to Clinical Applications using Biotechnology and Bioengineering". 2006, Poster 04.

 

Zheng L. and Cheung L.K., Effect of recombinant human bone morphogenetic protein-2 on mandibular distraction at different rates in a rabbit model, Asian J Oral Maxillofac Surg. 2006, 18:3 (Suppl 1): p.63.

 

Zheng L. and Cheung L.K., Effect of recombinant human bone morphogenetic protein-2 on mandibular distraction at different rates in a rabbit model, Tissue Engineering. 2006, 12: 3181-3188.

 

Zheng L. and Cheung L.K., Effect of recombinant human tissue inhibitor of matrix metalloproteinase-1 in rabbit mandibular distraction osteogenesis, 4th Tissue Engineering Symposium. 2007, p. 23.

 

Zheng L., Ma L. and Cheung L.K., Effect of recombinant human tissue inhibitor of matrix metalloproteinase-1 in rabbit mandibular distraction osteogenesis: a histological and immunohistochemical study, Journal of Cranio-maxillofacial Surgery. 2006, 34: 277-82.

 

Zheng L., Effect of rhBMP-2 on mandibular distraction osteogenesis, Transactions of 3rd Asia Pacific Congress on Craniofacial Surgery & Distraction osteogenesi. 2007, p187.

 

Zheng L., Surgical and biological approach for bone regeneration, Scientific Seminar in School of Stomatology, Wuhan University. 2007.

 

Researcher : Zhu H

List of Research Outputs

 

McGrath C.P.J., McMillan A.S. and Zhu H., Agreement between patient and proxy of life quality after stroke, Journal of Dental Research. 2007, 86 (Spec Iss A): 101.



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