DEPT OF PATHOLOGY
Researcher
: Au CWH |
List of Research Outputs |
Au
C.W.H., Siu
K.Y., Liao X., Ngan H.Y.S. and Cheung A.N.Y., Tropomyosin-related
kinase B and brain-derived neurotrophic factor in ovarian cancer.
[abstract]., In: American Association for Cancer Research Annual Meeting:
Proceedings; Apr 14-18; |
Researcher
: Au WH |
List of Research Outputs |
Cheung A.N.Y., Siu K.Y., Au W.H., Chan H.Y. and Wong E.S.Y., Follicle Stimulating Hormone can act on Receptors of Other Growth Hormones, Carcinogenesis. 2007, [Epub ahead of print]. |
Researcher
: Beh SL |
Project Title: |
The attitudes of doctors toward rape victims |
Investigator(s): |
Beh SL |
Department: |
Pathology |
Source(s) of Funding: |
Other Funding Scheme |
Start Date: |
06/1993 |
Abstract: |
To have an objective assessment of what the prevalent attitudes are; to ascertain if there is a gender bias; to compare local data with data from other countries; to compare data with other professional groups. |
Project Title: |
A STUDY OF
ANTECEDENT CLINICAL ENCOUNTERS OF VICTIMS OF DOMESTIC HOMICIDES IN |
Investigator(s): |
Beh SL |
Department: |
Pathology |
Source(s) of Funding: |
Small Project Funding |
Start Date: |
01/2006 |
Abstract: |
Prevention of domestic violence is one of
the central tasks of family protection. In Hong Kong various tools and
guidelines such as the Procedural Guidelines for Handling Battered Spouse
Cases (Working group on combating violence, 2004), are researched and
published to help social workers and other helping professionals to detect
signs of abuse in family. Central monitoring systems, such as the Child
Protection Registry and the Central Information System on Battered Spouses
Cases and Sexual Violence Cases are established to record and determine the nature
of suspected abuse cases. However, few efforts are paid to the understanding
of domestic homicides, despite its extreme and grievous nature. The fact that
fatal abuse cases were not included in the Child Protection Registry
highlights well the lack of understanding and study of lethal cases (Lee&
So,2005). This proposal argues that understanding domestic homicides is
crucial to family protection, considering the loss of lives, the
psychological damage to the surviving family and the psychological and
economic impact on the whole society (Brand, Sam, Price,and Richard, 2000).
Hong Kong also has a comparatively high proportion of domestic homicides
amongst all homicides compared with other jurisdictions, such as the |
Project Title: |
The role of LMO |
Investigator(s): |
Beh SL, Chan KW |
Department: |
Pathology |
Source(s) of Funding: |
Small Project Funding |
Start Date: |
11/2006 |
Abstract: |
LMO2 belongs to the family of LIM-only
proteins (LMO). The family consists of 4 members, designated LMO1-LMO4, known
to be important regulators in determining cell fate and controlling cell
growth and differentiation. To date, LMO2 has been extensively implicated to
play an important role in T-cell leukemia (T-ALL), yet the gene has not been
reported to be involved in any solid tumor.Our preliminary data by
semiquantitative RT-PCR analysis revealed that mRNA of LMO2 is highly
expressed in the more aggressive, androgen-independent PC3 and DU145 prostate
cancer cell lines but not in the less aggressive, androgen-dependent LNCaP
cell line. The aim of this proposed project is to further study the role LMO2
plays in driving prostate cancer progression.We aim to (1) determine the
protein expression of LMO |
List of Research Outputs |
Beh
S.L., Assessing Interpersonal Effectiveness
In Group Tutorials, In: David Carless, Gordon Joughin, Ngar-Fun Liu and
Associates, How Assessment Supports Learning. Learning -oriented
Assessment in Action. Hong Kong, |
Beh
S.L., Associate Editor for |
Beh S.L., Editorial, In: Philip S.L. Beh, Forensic Science International. Elsevier, 2006, 162: 1. |
Beh S.L., Guest Editorial, In: Philip S.L. Beh, Journal of Clinical Forensic Medicine. Elsevier, 2006, 13: 283. |
Beh S.L., The Coroners System - Is There A Future? A Hong Kong Perspective, 9th Cross Channel Conference. 2007. |
Beh
S.L., 評估小組導修的協作效能,
In: 梁佩雲,張淑賢, 導向學習的評估:教育實務匯編, |
Lee
K.W., Broadhurst R.G. and Beh S.L., Triad-related Homicides in
|
Ma S.K.Y., Guan X.Y., Beh S.L., Wong K.Y., Chan Y.P., Yuen H.F., Vielkind J. and Chan K.W., The significance of LMO2 expression in the progression of prostate cancer, The Journal of Pathology. 2006, 211(3): 278-85. |
Researcher
: Cao X |
List of Research Outputs |
Lam Q.L.K., Liu S., Cao X. and Lu L., Involvement of leptin signaling in the survival and maturation of bone marrow-derived dendritic cells, European Journal of Immunology. 2006, 36(12): 3118-30. |
Liu Q., Chen T., Chen G., Shu X., Sun A., Ma P., Lu L. and Cao X., Triptolide impairs dendritic cell migration by inhibiting CCR7 and COX-2 expression through PI3-K/Akt and NF-kappaB pathways, Molecular Immunology. 2007, 44(10): 2686-96. |
Researcher
: Chan ASY |
List of Research Outputs |
Chan
T.L., Yuen S.T., Kong C.K., Chan Y.W., Chan A.S.Y., Ng W.F., Tsui W.Y., Lo M.W.S., Tam W.Y., Li V.S.W. and Leung S.Y., Heritable germline
epimutation of MSH |
Chan
T.L., Yuen S.T., Kong C.K., Chan Y.W., Chan A.S.Y. and Leung S.Y., Heritable germline
epimutation of MSH |
Chan T.L., Guo D., Yuen S.T., Chan Y.W., Chan A.S.Y. and Leung S.Y., Immunohistochemical staining on tissue microarray of colorectal cancers constitutes a convenient means to rapidly screen for MMR deficiency, The Second Biennial Scientific Meeting of the International Society for Gastrointestinal Hereditary Tumours, InSiGHT, March 27-30, 2007, Yokohama, Japan. 2007. |
Chan
T.L., Yuen S.T., Lo M.W.S., Lee T.Y.H., Kong C.K., Chan Y.W., Tsui W.Y., Li V.S.W., Chan A.S.Y. and Leung S.Y., Study of the mechanisms
underlying heritable germline epimutation of MSH |
Guo D., Yuen S.T., Tsui W.Y., Chan A.S.Y., Chan T.L. and Leung S.Y., Expression of wnt signaling target genes in colorectal cancer progression, Proceedings of the 98th Annual Meeting of the American Association for Cancer Research. 2007. |
Li V.S.W., Yuen S.T., Chan A.S.Y., Tsui W.Y., Chen X. and Leung S.Y., Investigation of signaling pathways that regulate human colon crypt maturation and their dysregulation in tumorigenesis, Proceedings of the 98th Annual Meeting of the American Association for Cancer Research . 2007. |
Sheng J.Q., Chan T.L., Chan Y.W., Huang J.S., Chen J.G., Zhang M.Z., Guo X.L., Mu H., Chan A.S.Y., Li S.R., Yuen S.T. and Leung S.Y., Microsatellite instability and novel mismatch repair gene mutations in northern Chinese population with Hereditary non-polyposis colorectal cancer, Chin J Dig Dis . 2006, 7(4): 197-205. |
Researcher
: Chan DW |
Project Title: |
Characterization of the roles of Dual specificity MAPK phosphatase 3 (MKP-3) in ovarian cancer |
Investigator(s): |
Chan DW, Ngan HYS |
Department: |
Obstetrics & Gynaecology |
Source(s) of Funding: |
Small Project Funding |
Start Date: |
11/2006 |
Abstract: |
Ovarian cancer is one of the leading
causes of death in women. Although there have been advances in the treatment
of ovarian cancer, the associated mortality rate of this cancer has not
improved significantly over the past decade. Therefore, understanding the
molecular mechanisms in the development of ovarian cancer through
identification and characterization of oncogenes and tumor suppressor genes
will help discovery of novel targets for therapies. To achieve this, we have
previously done cDNA microarray analysis on ovarian cancer cell lines and
immortalized human normal surface epithelial cell lines (HOSEs). We found
that a gene called Dual specificity MAPK phophatase 3 (MKP-3/DUSP6) was
downregulated in ovarian cancer cells. Many studies have documented that
MKP-3 possesses anti-tumorigenic effect on pancreatic cancer through
inactivation of ERK activity (Furukawa et al., 1998; Furukawa et al., 2003).
The finding of underexpression of MKP |
List of Research Outputs |
Chan D.W. and Ng I.O.L., Identification of CPGL-B as a candidate suppressor in cell growth and metastasis in human hepatocellular carcinoma, Clinical Cancer Research. 2006, 12: 6617-6625. |
Chan D.W., Chan P.C.Y., Yam J.W.P., Ching Y.P. and Ng I.O.L., Prickle-1 negatively regulates wnt/beta-catenin pathway by promoting dishevelled ubiquitination/degradation in liver cancer, Gastroenterology. USA, Elsevier Inc, 2006, 131: 1218-1227. |
Zhang P., Chan D.W., Zhu Y.Y., Li J.J., Ng I.O.L., Wan D.F. and Gu J.R., Identification of carboxypeptidase of glutamate like-B as a candidate suppressor in cell growth and metastasis in human hepatocellular carcinoma, Clinical Cancer Research. 2006, 12(22): 6617-6625. |
Researcher
: Chan EYT |
List of Research Outputs |
Hon C., Yau K., Chan E.Y.T., Lee K.K. and Au W.Y., Graves' ophthalmopathy after allogeneic stem cell transplantation, Annals of Hematology. 2006, 85(12): 887-888. |
Researcher
: Chan GSW |
List of Research Outputs |
Chan G.S.W. and Chan K.W., Fetal Decidua, International Journal of Surgical Pathology. 2006, 14(4): 328. |
Chan G.S.W., Chim S., Fan Y.S. and Chan K.W., Focal segmental glomerulosclerosis after membranous glomerulonephritis in remission: temporal diversity of glomerulopathy after bone marrow transplantation, Human Pathology. 2006, 37(12): 1607-10. |
Fan Y.S., Khoo U.S. and Chan G.S.W., A retroperitoneal immature teratoma with rhabdomyoblastic and nephroblastic differentiation., Pathology. 2006, 38(4): 364-7. |
Lam M.F., Au W.Y., Tse K.C., Chan D.T.M., Chan G.S.W., Chan K.W. and Lai K.N., Late onset membranous nephropathy complicating donor lymphocyte infusion for Leukaemia relapse after allogeneic stem cell transplantation, American Journal of Hematology. 2007, 82(4): 327-328. |
Researcher
: Chan HY |
List of Research Outputs |
Cheung A.N.Y., Siu K.Y., Au W.H., Chan H.Y. and Wong E.S.Y., Follicle Stimulating Hormone can act on Receptors of Other Growth Hormones, Carcinogenesis. 2007, [Epub ahead of print]. |
Siu
K.Y., Woo N.W., Wong E.S.Y., Chan H.Y., Ngan H.Y.S. and Cheung A.N.Y., Biological significant of
p21-activated kinase |
Researcher
: Chan KK |
List of Research Outputs |
Yuen H.F., Chan Y.P., Wong M.L.Y., Kwok W.K., Chan K.K., Lee P.Y., Srivastava G., Law S.Y.K., Wong Y.C., Wang X. and Chan K.W., Upregulation of Twist in oesophageal squamous cell carcinoma is associated with neoplastic transformation and distant metastasis, Journal of Clinical Pathology. 2006, 60(5): 510-514. |
Researcher
: Chan KW |
Project Title: |
The significance of TWIST and DERMO-1 expressions in prostatic cancer |
Investigator(s): |
Chan KW |
Department: |
Pathology |
Source(s) of Funding: |
Small Project Funding |
Start Date: |
10/2005 |
Completion Date: |
10/2006 |
Abstract: |
The objective of the proposed study is to
investigate the expression of DERMO |
Project Title: |
Prognostic significance of Id proteins in esophageal squamous cell carcinoma (ESCC) |
Investigator(s): |
Chan KW |
Department: |
Pathology |
Source(s) of Funding: |
Small Project Funding |
Start Date: |
11/2006 |
Abstract: |
Purpose of the proposed project: The
proposed project aims to clarify the roles of Id-proteins in the oncogenesis
and progression of esophageal squamous cell carcinoma (ESCC) and to explore
the potentials for using them as prognostic markers and targets for therapy
of ESCC. To achieve the goals, the following two approaches are to be
adopted. (i) To study how Id proteins expressions differ in normal human
esophageal epithelial and esophageal cancer cell lines. (ii) To establish the
prognostic significance of the expression of each Id proteins in ESCC by
determining and correlating their expression levels in primary ESCC with
clinical staging, histological grading, disease progression and clinical
outcome. Background: Esophageal cancer is the eighth most common cancer and
the sixth most common cancer-related death worldwide. A 20-fold higher risk
was observed in |
List of Research Outputs |
Chan
D.T.M., Tsang R.C.W., Chan K.W. and Yung S.S.Y., Anti-DNA antibodies
stimulate hyaluronan synthesis in proximal tubular epithelial cells through
the induction of IL-6 and IL-1b, Journal of the American Society of
Nephrology. 2006, 17: |
Chan G.S.W. and Chan K.W., Fetal Decidua, International Journal of Surgical Pathology. 2006, 14(4): 328. |
Chan G.S.W., Chim S., Fan Y.S. and Chan K.W., Focal segmental glomerulosclerosis after membranous glomerulonephritis in remission: temporal diversity of glomerulopathy after bone marrow transplantation, Human Pathology. 2006, 37(12): 1607-10. |
Chan
K.W., Pathology of Transplant Kidney, The |
Chung M.F., Lam A.K.Y., Luk J.M.C., Law S.Y.K., Chan K.W., Lee P.Y. and Wong J., Clinical significance of e-cadherin and p120 catenin expression and localization in esophageal squamous cell carcinoma, 11th Research Postgraduate Symposium (11th RPS), The University of Hong Kong Li Ka Shing Faculty of Medicine, Hong Kong, 7 December. 2006. |
Fung K.L., Cheung H.W., Wong H.L., Yuen H.F., Ling M.T., Chan K.W., Wong Y.C., Cheung A. and Wang X., MAD2 expression and its significance in mitotic checkpoint control in testicular germ cell tumour. , Biochimica et Biophysica Acta - Molecular Cell Research . 2007, 1773: 821-832. |
Lam M.F., Tse K.C., Chan G., Chan K.W., Chan D.T.M. and Lai K.N., De Novo glomerulonephritis
after hemopoietic stem cell transplantation, Journal
of American Society of Nephrology. 2006, 17: |
Lam M.F., Au W.Y., Tse K.C., Chan D.T.M., Chan G.S., Chan K.W. and Lai K.N., Hyperleptinaemia and chronic inflammation after peritonitis predicts poor nutritional status and mortality in patients on peritoneal dialysis, Nephrology Dialysis Transplantation. 2007, 32: 1445-1450. |
Lam M.F., Au W.Y., Tse K.C., Chan D.T.M., Chan G.S.W., Chan K.W. and Lai K.N., Late onset membranous nephropathy complicating donor lymphocyte infusion for Leukaemia relapse after allogeneic stem cell transplantation, American Journal of Hematology. 2007, 82(4): 327-328. |
Lui S.L., Chan K.W., Tsang R.C.W., Yung S.S.Y., Lai K.N. and Chan D.T.M., Effect of rapamycin on renal ischemia-reperfusion injury in mice, Transplant International. 2006, 19: 834-839. |
Lui
S.L., Yung S.S.Y., Tsang R.C.W., Chan K.W., Zhang Q., Tam S., Lai K.N. and Chan D.T.M., Rapamycin attenuates the
severity of nephritis in NZB/NZW mice, Journal of the American Society of
Nephrology. 2006, 17: |
Lui
S.L., Yung S.S.Y., Tsang R.C.W., Chan K.W., Zhang Q., Tam S., Lai K.N. and Chan D.T.M., Rapamycin reduces
proteinuria and segmental glomerulosclerosis in murine adriamycin
nephropathy, Journal of the American Society of Nephrology. 2006, 17: |
Ma S.K.Y., Chan K.W., Ng I.O.L., Zheng B. and Guan X.Y., Identification and characterization of CD133+ hepatocellular carcinoma cells as cancer stem/progenitor cells, The 5th International Society for Stem Cell Research, June 2007, Cairns, Australia. 2007. |
Ma S.K.Y., Chan K.W. and Guan X.Y., Identification and characterization of tumorigenic liver cancer stem cells, Oral Presentation in the Young Investigator Award Session, The 13th Hong Kong International Cancer Congress, November 2006, Hong Kong. 2006. |
Ma S.K.Y., Chan K.W., Hu L., Lee K.W., Ng I.O.L., Wo Y.H., Zheng B. and Guan X.Y., Identification and characterization of tumorigenic liver cancer stem cells, Proceedings of the Annual Meeting of American Association for Cancer Research, Los Angeles, USA, April. 2007. |
Ma S.K.Y., Chan K.W. and Guan X.Y., Identification and characterization of tumorigenic liver cancer stem cells, The 11th Research Postgraduate Symposium, The University of Hong Kong, December 2006, Hong Kong. 2006. |
Ma S.K.Y., Chan K.W., Hu L., Lee K.W., Wo Y.H., Ng I.O.L., Zheng B. and Guan X.Y., Identification and characterization of tumorigenic liver cancer stem/progenitor cells, Gastroenterology. 2007, 132(7): 2542-2556. |
Ma S.K.Y., Guan X.Y., Beh S.L., Wong K.Y., Chan Y.P., Yuen H.F., Vielkind J. and Chan K.W., The significance of LMO2 expression in the progression of prostate cancer, The Journal of Pathology. 2006, 211(3): 278-85. |
Tang S.C.W., Chan K.W., Tang C.S.O., Lam M.F., Leung C.Y., Tse K.C., Li C.S., Ho Y.W., Tong K.L., Lai K.N., Chan D.T.M. and Hong Kong Nephrology Study Group ., Conversion of ciclosporin A to tacrolimus in kidney transplant recipients with chronic allograft nephropathy, Nephrology Dialysis Transplantation. 2006, 21(11): 3243-51. |
Tsun O.K.L., Yeung Y.H., Chan Y.K., Siu K.Y., Szeto E.F., Chan K.Y.Q., Chan K.W. and Cheung A.N.Y., Cervical Cytology Screening in Pregnant Women, International Cancer Congress (13th), Hong Kong, 15 - 17 November 2006. |
Yuen
H.F., Chua C.W., Chan Y.P., Wong Y.C., Wang X. and Chan K.W., Id proteins expression in
prostate cancer: high-level expression of Id |
Yuen H.F., Chua C.W., Chan Y.P., Wong Y.C., Wang X. and Chan K.W., Significance of TWIST and E-cadherin expression in the metastatic progression of prostatic cancer, Histopathology. 2007, 50(5): 648-58. |
Yuen H.F., Chan Y.P., Wong Y.C., Wang X. and Chan K.W., The prognostic significance of Id proteins in Esophageal Squamous Cell Carcinoma, The 97th American Association of Cancer Research Annual Meeting, Los Angeles, USA, April. 2007. |
Yuen H.F., Chan Y.P., Wong M.L.Y., Kwok W.K., Chan K.K., Lee P.Y., Srivastava G., Law S.Y.K., Wong Y.C., Wang X. and Chan K.W., Upregulation of Twist in oesophageal squamous cell carcinoma is associated with neoplastic transformation and distant metastasis, Journal of Clinical Pathology. 2006, 60(5): 510-514. |
Researcher
: Chan KYQ |
List of Research Outputs |
Chan K.Y.Q., Ngan H.Y.S., Ip P.P.C., Liu V.W.S., Xue W. and Cheung A.N.Y., Follistatin-like 1 is important for ovarian and endometrial carcinogenesis – a differential expression and functional analysis, 98th Annual Meeting of American Association for Cancer Research, 14-18 April. 2007. |
Chan K.Y.Q., Ngan H.Y.S., Chan Y.K., Siu K.Y., Chiu P.M., Khoo U.S., Ip P.P.C. and Cheung A.N.Y., Significance of single
nucleotide polymorphism of the metabolizing enzyme NQO |
Chan K.Y.Q., Ngan H.Y.S., Chan Y.K., Siu K.Y., Chiu P.M., Khoo U.S., Ip P.P.C. and Cheung A.N.Y., Single Nucleotide Polymorphism of Metabolizing Enzymes is Associated with Risk of Ovarian Carcinoma in Chinese Women, The 8th International Meeting on Human Genome Variation & Complex Genome Analysis, Hong Kong, 14-16 September. 2006. |
Ip P.P.C., Lam K.W., Yeung C.W., Pun T.C., Chan K.Y.Q. and Cheung A.N.Y., Tranexamic Acid Associated Necrosis and Intra-lesional Thrombosis of Uterine Leiomyomas: A clinicopathologic study of 490 Cases Emphasizing the Importance of Drug-induced Necrosis, Montreal IAP, 16-21 September. 2006. |
Tsun O.K.L., Yeung Y.H., Chan Y.K., Siu K.Y., Szeto E.F., Chan K.Y.Q., Chan K.W. and Cheung A.N.Y., Cervical Cytology Screening in Pregnant Women, International Cancer Congress (13th), Hong Kong, 15 - 17 November 2006. |
Researcher
: Chan LC |
Project Title: |
Ras signaling in human leukaemia |
Investigator(s): |
Chan LC, Kong CT |
Department: |
Pathology |
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
Start Date: |
01/2005 |
Abstract: |
To study: (1) Identification of the possible interaction between other MLL fusion partners and components of Ras-mediated pathways. i) design of MLL fusion partner constructs. ii) analysis of transactivation of E1K-1, a target of Ras pathway signaling. iii)soft agar transformation assay. (2) Molecular dissection of the potential functional link between Ras-signaling and MLL-AF6 fusion mediated leukaemogenesis using the ML-1 cell line. i) molecular analysis of Ras signaling pathway following suppression of MLL-AF6 expression in ML-1 cell line . ii) effects of inhibition of Ras signaling pathway on cellular growth and apotosis of ML-1 cell line . (3) Validation of the pathogenic significance of Ras-signaling pathway in MLL fusion mediated leukaemogenesis using an Mll-Een knock-in model. i) effects on suppression of Ras signaling pathway on growth and differentiation of embryonic bodies and haemopoiesis colonies derived from Mll-Een targeted ES cells. |
Project Title: |
ATM mutations in childhood leukaemia |
Investigator(s): |
Chan LC, Ha SY |
Department: |
Pathology |
Source(s) of Funding: |
Michael Kadoorie Cancer Genetics Research Fund |
Start Date: |
01/2005 |
Abstract: |
To screen for ATM gene mutations in childhood ALL samples from Hong Kong, Shanghai, Tokyo and London, UK; to determine the germline status of the ATM gene in patients whose diagnostic samples showed mutations; to determine the presence of ATM mutations or allelic variations in the normal population of samples. |
Project Title: |
Application of the FICTION (fluorescence immunophenotyping and interphase cytogenetics as a tool for the investigation of neoplasms) technique on blood and bone marrow aspirate specimens to study leukaemias |
Investigator(s): |
Chan LC |
Department: |
Pathology |
Source(s) of Funding: |
Small Project Funding |
Start Date: |
01/2007 |
Abstract: |
Fluorescence in-situ hybridization (FISH)
is an established method to detect numerical and structural chromosomal
abnormalities in leukaemia. Using fluorescent dye-labelled nucleic acid
probes, genetic defects including specific chromosome loss/gain, deletion and
translocation can be detected in interphase leukaemic cells, thus obviating
the need to perform cell culture to analyse cells in mitosis as in conventional
cytogenetics. One distinct disadvantage of FISH is inability to correlate
cell phenotype with genetic defects studied. In solid tumours this is less of
a problem because of their cohesive and relative monotonous nature, thus
rendering identification of tumour cells easier. However, the cell types in
leukaemias are very heterogeneous and many non-neoplastic cells are often
admixed with leukaemic cells in blood and bone marrow aspirate. Prior
purification by cell sorting, using either flow or magnetic activated
technique, is necessary if phenotype-genotype correlation is indicated.
Sorting is also required to minimize false negativity due to the presence of
contaminating normal cells. FICTION protocols for histological sections
including trephine biopsy have been published. However, a corresponding
technique for blood and marrow aspirate specimens has not been well studied.
The objective of the research proposal is to develop a standard FICTION
technique applicable to blood and bone marrow aspirate specimens. References:
Weber-Matthiesen K, Winkemann M, Muller-Hermelink A, Schlegelberger B, Grote
W. Simultaneous detection of the immunophenotypic markers and genetic
aberrations on routinely processed paraffin sections of lymphoma samples by
means of the FICTION technique. J Histochem Cytochem. 1992;40:171-5.
Martinez-Ramirez A, Cigudosa JC, Maestre L, Rodriguez-Perales S, Haralambieva
E, Benitez J, Roncador G. Simultaneous detection of the immunophenotypic
markers and genetic aberrations on routinely processed paraffin sections of
lymphoma samples by means of the FICTION technique. Leukemia. 2004;18:348-53.
Korac P, Jones M, Dominis M, Kusec R, Mason DY, Banham AH, |
Project Title: |
Expression and cellular localization studies of TCF12, a new leukaemia fusion partner gene, in normal and malignant haemopoiesis and the generation of mouse embryonic stem cells bearing MLL-TCF12 through homologous recombination |
Investigator(s): |
Chan LC |
Department: |
Pathology |
Source(s) of Funding: |
Germany/Hong Kong Joint Research Scheme |
Start Date: |
01/2007 |
Abstract: |
1. To determine the expression profile of
TCF |
List of Research Outputs |
Chan
L.C., A mouse model of human leukaemia, Monthly
Scientific Meeting – |
Chan L.C., American Journal of Haematology. 2006. |
Chan
L.C., Childhood Leukaemia, Infection and
Immunity – what is the link?, The 7th Symposium of Molecular and Cellular
Immunity, |
Chan Y.Y., So J.C.C., Ma E.S.K. and Chan L.C., A laboratory strategy for genotyping hemoglobin H disease in the Chinese, J Clin Pathol. 2006, 60(8): 931-4. |
Cheung
N., Yam J.W.P., Chan L.C., Cleary M.L. and So E.C.W., Identification of an oncogene
MLL fusion complex with histone methylation and acetylation activities, 48th
Annual Meeting American Society of Haematology, Orlando, USA. December 9-12.
2006, Blood Vol 108 No. 11 Part 1: |
Ko K.H., Lam Q.L.K., Zhang M., Wong C.K.Y., Lo K.C., Kahmeyer-Gabbe M., Tsang W.H., Tsang S.L., Chan L.C., Sham M.H. and Lu L., Hoxb3 deficiency impairs B lymphopoiesis in mouse bone marrow, Experimental Hematology. 2007, 35(3): 465-75. |
Patil
N.G. and Chan L.C.,
Assessment of Medical Schools: Who cares?, AMEE, |
So
J.C.C., Chan A.Y.Y., Tsang S.T.Y.,
Lee A.C.W., Au W.Y., Ma E.S.K. and Chan L.C., A novel beta-delta globin
gene fusion leads to over-expression of delta globin chain and a mild
thalassemia intermedia phenotype when co-inherited with beta-zero
thalassemia, 48th American Society of Hematology Annual Meeting and
Expositions. 2006, Blood Vol 108 No. 11 Part 1: |
So J.C.C., Chan Y.Y., Tsang S.T.Y., Lee C.W., Au W.Y., Ma E.S.K. and Chan L.C., A novel beta-delta globin gene fusion, anti-Lepore Hong Kong, leads to overexpression of delta globin chain and a mild thalassaemia intermedia phenotype when co-inherited with b0-thalassaemia, British Journal of Haematology. 2006, 136(1): 158-162. |
So J.C.C., Wan T.S.K., Yip S.F., Ma E.S.K., Lam C.C.K. and Chan L.C., Can morphological assessment limit the use of specific genetic testing to exclude chronic myeloid leukaemia?, Br J Haematol. 2007, 137(4): 377. |
Tsang
H.M., Kong C.T., Sham M.H. and Chan L.C., Analysis of Mll-Een
Fusion Gene in Mouse Leukemic Model, Keystone Symposium - Mouse Models at
the Frontiers of Cancer Discovery. Whistler Resort, Whistler, |
Wan T.S.K., So J.C.C., Hui K.C., Yip S.F., Ma E.S.K. and Chan L.C., Diagnostic utility of dual fusion PML/RARalpha translocation DNA probe (D-FISH) in acute promyelocytic leukemia, Oncol Rep. 2007, 17(4): 799-805. |
Yip
S.F., Wan T.S.K., Liu H.S., Wong
M.L., So J.C.C. and Chan L.C., |
Yip S.F., Wan T.S.K., Liu H.S., Wong M.L. and Chan L.C., The Philadelphia-Chromosome is unmasked as the secondary genetic change in acute myeloid leukemia on imatinib treatment, 48th Annual Meeting American Society of Haematology, Orlando, USA. December 9-12 . 2006, Blood Vol 108 No. 11 Part 2: 219b. |
Researcher
: Chan PCY |
List of Research Outputs |
Chan D.W., Chan P.C.Y., Yam J.W.P., Ching Y.P. and Ng I.O.L., Prickle-1 negatively regulates wnt/beta-catenin pathway by promoting dishevelled ubiquitination/degradation in liver cancer, Gastroenterology. USA, Elsevier Inc, 2006, 131: 1218-1227. |
Wong C.M., Ng Y.L., Lee M.F., Wong C.L., Cheung O.F., Chan P.C.Y., Tung K.K., Ching Y.P. and Ng I.O.L., Tissue factor pathway inhibitor-2 as a frequently silenced tumor suppressor gene in hepatocellular carcinoma, Hepatology. 2007, 45(5): 1129-1138. |
Yam J.W.P., Ko C.F., Chan P.C.Y., Yau T.O., Tung K.K., Leung T.H.Y., Jin D. and Ng I.O.L., Tensin2 variant 3 is associated with aggressive tumor behavior in human hepatocellular carcinoma, Queenstown Signal Transduction Meeting, New Zealand. 2006. |
Researcher
: Chan QKY |
List of Research Outputs |
Yang C., Chan Y.K., Ngan H.Y.S., Khoo U.S., Chiu P.M., Chan Q.K.Y., Xue W. and Cheung A.N.Y., Single nucleotide polymorphisms of follicle-stimulating hormone receptor are associated with ovarian cancer susceptibility, Carcinogenesis. 2006, 27: 1502-6. |
Researcher
: Chan SY |
List of Research Outputs |
Chan Y.K., Tse Y.T., Chan S.Y., Liu W., Garcia-Barcelo M.M., Sham P.C. and Khoo U.S., Estrogen receptors genetic polymorphisms risk association and their functional roles in breast cancer risk: a study on Hong Kong Chinese women, 100th American Association for Cancer Research Annual Meeting, Los Angeles, CA, USA . 2007, Abstract no. 5269. |
Khoo
U.S., Liu W., Long J.R., Yip
S.P., Cheung A.N.Y., Chua D.T.T., Chan S.Y., Ngan H.Y.S., Zheng W. and Chan Y.K., The functional |
Tse
Y.T., Chan Y.K., Chan S.Y., Xu M.S., Sham P.C. and Khoo U.S., Estorgen Receptors Genes and
Breast cancer Risk in Chinese: A Haplotype-based Analysis, International
Cancer Congress (13th), |
Researcher
: Chan TL |
Project Title: |
Molecular characterisation of the serrated neoplasia pathway and its role in the development of colorectal cancer with mismatch repair deficiency |
Investigator(s): |
Chan TL, Leung SY, Yuen ST |
Department: |
Pathology |
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
Start Date: |
01/2005 |
Abstract: |
Colorectal cancer (CRC) is one of the commonest
cancers world-wide with 850,000 new cases each year. Majority of CRC are
known to develop through an adenoma-carcinoma sequence, with molecular
genetic changes that characterize each transition step. Adenoma is considered
pre-malignant and early prevention and treatment of CRC is possible through
regular endoscopic surveillance and removal of tumour at the adenoma stage.
However, despite regular surveillance, some patients still develop CRC. One
of the possibilities is that there exists another pathway of tumour
development. Recently, there are data to suggest the existence of an
alternative route, the serrated neoplasia pathway, for CRC development. This
latter pathway includes those serrated polyps (SP) that span a morphological
spectrum from hyperplastic polyp (HP) to serrated adenoma (SA). The earliest
member in this pathway, HP, is a very common lesion in aged individuals and
it is a long held belief that HPs are innocent with little propensity for
malignant progression. However, a small subset of HPs may progress but the
criteria to distinguish the high risk versus the low risk ones are unclear.
Concurrently, it is known that a subset (15%) of sporadic CRC manifest a form
of genetic instability called microsatellite instability (MSI). This is due
to promoter methylation leading to loss of expression of the DNA mismatch
repair protein MLH1. The evolution of this subset of CRC is unclear as a
preceding adenoma phase is very rarely seen. Recently, studies by us and
others have provided molecular evidences to suggest that there may be a
strong link between the serrated neoplasia pathway and the development of
sporadic CRC with MSI. These include the identification of a high incidence
of BRAF mutation in HPs and SAs, the occurrence of MSI in some SPs and the
selective association of BRAF mutation with sporadic late-onset CRC with MSI.
Our recent pilot study has shown that MLH1 inactivation can be detected in
SPs at its very early phase and these can just involve several crypts within
the lesion. With these data, we propose to perform a large scale phenotypic
and molecular characterization of serrated polyps at their early phase of
evolution to define the link between SPs and MSI CRC, and the temporal
sequence of genetic changes in this pathway. Aims: 1. To look for evidence of
MLH1 inactivation in various stages of evolution of serrated polyps, and to
document its incidence and phenotypic characteristics. 2. To document the
occurrence of microsatellite instability and frameshift mutation in growth
regulatory genes containing microsatellite encoding region as consequences of
MLH1 inactivation in various stages of serrated polyps. 3. To analyse the
inter-relationship between MLH1 inactivation, BRAF/KRAS mutations and
presence of the CpG |
Project Title: |
Allele-specific imbalance in gene expression as a cause for hereditary colorectal cancer |
Investigator(s): |
Chan TL, Leung SY, Yuen ST |
Department: |
Pathology |
Source(s) of Funding: |
Michael Kadoorie Cancer Genetics Research Fund |
Start Date: |
01/2005 |
Abstract: |
To look for allele-specific imbalance in gene expression of the Adenomatous Polyposis Coli (APC), MSH2 and MLH1 genes in FAP or HNPCC patients with undetectable germline mutation; to confirm the pathological significance of the allele with a lower gene expression level by examination for co-segregation with disease and loss of the wild-type allele in cancer tissue; to look for mechanisms that can account for the reduced gene expression level in the disease allele. |
Project Title: |
Molecular characterisation of the serrated neoplasia pathway and its role in the development of colorectal cancer with mismatch repair deficiency |
Investigator(s): |
Chan TL, Leung SY, Yuen ST |
Department: |
Pathology |
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
Start Date: |
12/2005 |
Abstract: |
To look for evidence of MLH1 inactivation in various stages of evolution of serrated polyps, and to document its incidence and phenotypic characteristics; to document the occurrence of microsatellite instability and frameshift mutation in growth regulatory genes containing microsatellite encoding region as consequences of MLH1 inactivation in various stages of serrated polyps; to analyse the inter-relationship between MLH1 inactivation, BRAFIKRAS mutations and presence of the CpG Island Methylator Phenotype in SPs and their temporal sequence of occurrence; to look for alteration in major molecular genetic pathways in SPs with MLH1 inactivation; to look for evidence of a field effect of MLH1 inactivation in the colon in patients with sporadic late-onset MSI colorectal cancer with MLH1 promoter methylation; to look for clinical, morphological or molecular markers that can distinguish SPs with high risk of progression to MSI CRC. |
Project Title: |
Expression of microRNAs in various stages and pathways of colorectal carcinogenesis |
Investigator(s): |
Chan TL, Leung SY, Yuen ST |
Department: |
Pathology |
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
Start Date: |
02/2006 |
Abstract: |
MicroRNAs (miRNAs) are a newly discovered class of non-protein coding RNAs that play important roles in embryonic development and many biological processes in diverse species. They function to regulate expression of other protein-coding genes by promoting their mRNA degradation or inhibiting their protein translation. Though the precise functions of individual miRNA and the repertoire of target genes that they each regulates are mostly unknown, emerging data suggest their involvement in regulating some major oncogenic pathways including those mediated by the RAS and the c-myc genes. miRNAs reside frequently in genomics regions involved in cancers. Deranged expression of miRNAs has been reported in several cancer types. The miRNA expression profile can distinguish histological cell lineage of cancers and can even distinguish molecular pathways of transformation for cancers derived from the same cell lineage. Colorectal cancer (CRC) is one of the most common cancers worldwide. Several major molecular pathways of CRC development is currently known, including the APC/KRAS/p53/chromosome instability pathway and the microsatellite instability/TGF pathway. Currently, little is known regarding the expression profiles of miRNAs in colon, and whether there is deregulated expression of specific miRNAs in various stages or pathways of CRC development. In this study we aim to systematically profile the expression of miRNAs, using a high-throughput quantitative RT-PCR analysis method, in various stages and pathways of CRC development, with an aim to gain a better understanding of their possible involvement in colon carcinogenesis. Aims 1) To profile the expression of miRNAs in normal mucosae, adenomas and carcinomas of the colon, and to compare the differences in miRNA expression profiles of the progenitor cells residing at the base of the crypt and the mature cells residing at the top. 2) To compare the variation in expression of miRNAs in different molecular subtypes of CRC including those with microsatellite instability, microsatellite stable or microsatellite and chromosome stable phenotype. 3) To identify specific miRNAs of interest that show altered expression in the course of CRC development, or in specific molecular subgroups of CRC 4) To investigate the function of these miRNAs by over-expression or gene silencing approach in cell culture system. 5) To delineate the putative protein-coding target(s) regulated by these miRNA(s) using bioinformatics approach and their validation by western blotting. |
Project Title: |
Expression of microRNAs in various stages and pathways of colorectal |
Investigator(s): |
Chan TL, Leung SY, Yuen ST |
Department: |
Pathology |
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
Start Date: |
01/2007 |
Abstract: |
To profile the expression of miRNAs in normal mucosae, adenomas of the colon, and to compare the differences in miRNA expression profiles of the progenitor cells residing at the base of the crypt and the mature cells residing at the top; to compare the variation in expression of miRNAs in different molecular subtypes of CRC including those with microsatellite instability, microsatellite stabel or microsatellite and chromosome stable phenotype; to identify specific miRNAs if interest that show altered expression in the course of CRC development, or in specific molecular subgroups of CRC; to investigate the function of these miRNAs by over-expression or gene silencing appraoch in cell culture system; to delineated the putative protein-coding target(s) regulated by these miRNA(s) using bioinformatics approach and their validation by western blotting. |
List of Research Outputs |
Chan
T.L., Epigenetics of Cancer: Insight from
Colorectal Carcinoma, 13th |
Chan
T.L., Yuen
S.T., Kong C.K., Chan Y.W., Chan A.S.Y., Ng W.F., Tsui W.Y., Lo M.W.S., Tam W.Y., Li V.S.W. and Leung S.Y., Heritable germline
epimutation of MSH |
Chan
T.L., Yuen
S.T., Kong C.K., Chan Y.W., Chan A.S.Y. and Leung S.Y., Heritable germline
epimutation of MSH |
Chan T.L., Guo D., Yuen S.T., Chan Y.W., Chan A.S.Y. and Leung S.Y., Immunohistochemical staining on tissue microarray of colorectal cancers constitutes a convenient means to rapidly screen for MMR deficiency, The Second Biennial Scientific Meeting of the International Society for Gastrointestinal Hereditary Tumours, InSiGHT, March 27-30, 2007, Yokohama, Japan. 2007. |
Chan
T.L., Yuen
S.T., Lo M.W.S., Lee T.Y.H., Kong C.K., Chan Y.W., Tsui W.Y., Li V.S.W., Chan A.S.Y. and Leung S.Y., Study of the mechanisms
underlying heritable germline epimutation of MSH |
Edkins S., O'meara S., Parker A., Stevens C., Reis M., Jones S., Greenman C., Davies H., Dalgliesh G., Forbes S., Hunter C., Smith R., Stephens P., Goldstraw P., Nicholson A., Chan T.L., Velculescu V.E., Yuen S.T., Leung S.Y., Stratton M.R. and Futreal A., Recurrent KRAS Codon 146 Mutations in Human Colorectal Cancer, Cancer Biology & Therapy. 2006, 5(8): 928-932. |
Guo D., Yuen S.T., Tsui W.Y., Chan A.S.Y., Chan T.L. and Leung S.Y., Expression of wnt signaling target genes in colorectal cancer progression, Proceedings of the 98th Annual Meeting of the American Association for Cancer Research. 2007. |
Leung S.Y., Chan T.L. and Yuen S.T., Reply to "Heritable germline epimutation is not the same as transgenerational epigenetic inheritance", Nat Genet. 2007, 39(5): 576. |
Sheng J.Q., Chan T.L., Chan Y.W., Huang J.S., Chen J.G., Zhang M.Z., Guo X.L., Mu H., Chan A.S.Y., Li S.R., Yuen S.T. and Leung S.Y., Microsatellite instability and novel mismatch repair gene mutations in northern Chinese population with Hereditary non-polyposis colorectal cancer, Chin J Dig Dis . 2006, 7(4): 197-205. |
Project Title: |
The signaling pathways of L-SIGN in response to ligand binding |
Investigator(s): |
Chan YK, Khoo |
Department: |
Pathology |
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
Start Date: |
03/2007 |
Abstract: |
L-SIGN (liver/lymph node-specific ICAM-3
grabbing non-integrin) serves as a receptor for many of viral pathogens,
including HIV1;2, HCV3, Ebola virus4, and SARS coronavirus (SARS-CoV)5. Its
homologue, DC-SIGN, also serves as a receptor for many of the same viruses
and has been utilized by some of the pathogens to escape immuno-surveillance.
The binding sites of L-SIGN and DC-SIGN appear evolved to serve different
functions. DC-SIGN mediates trafficking as a recycling receptor, releasing
ligand at endosomal pH. In contrast, L-SIGN does not release ligands at
endosomal pH nor does it mediate endocytosis, which indicates that it only
functions as a binding receptor6. L-SIGN on transfected cells has been shown
to internalize HCV virus-like particles and traffic to either lysosomal or
non-lysosomal compartment depending on the cell type7. We speculate that
L-SIGN may have other un-explored functions and signaling events after L-SIGN
engagement with its ligand. Mitogen-activated protein kinases (MAPKs) are
signal transducers that respond to extracellular stimulations, such as
cytokines and viral infection. They in turn regulate cell differentiation,
proliferation, survival and apoptosis8-11. There are three distinct MAPK
cascades, extracellular signal-regulated kinases (ERK1/2), c-JUN N-terminal
kinases (JNK), and p38/MAPK. Phosphatidylinositol 3-kinase (PI3K) signaling
pathway also plays an important role in various cellular processes including
cell growth and survival, vesicular trafficking, etc12. One of the key
signaling molecules in the pathway is AKT which phosphorylates targets
including GSK-3, FKHR-L1 and BAD. SARS-CoV infected permissive Vero E6 cells
(which express the SARS-CoV receptor, ACE213) has been demonstrated to activate
the MAPK and PI3K/Atk signaling pathways14-16. p38/MAPK has been shown to be
activated during SARS-CoV viral replication |
List of Research Outputs |
Chan
K.Y.Q., Ngan H.Y.S., Chan Y.K., Siu K.Y., Chiu P.M., Khoo U.S., Ip P.P.C. and Cheung A.N.Y., Significance of single
nucleotide polymorphism of the metabolizing enzyme NQO |
Chan K.Y.Q., Ngan H.Y.S., Chan Y.K., Siu K.Y., Chiu P.M., Khoo U.S., Ip P.P.C. and Cheung A.N.Y., Single Nucleotide Polymorphism of Metabolizing Enzymes is Associated with Risk of Ovarian Carcinoma in Chinese Women, The 8th International Meeting on Human Genome Variation & Complex Genome Analysis, Hong Kong, 14-16 September. 2006. |
Chan Y.K., Tse Y.T., Chan S.Y., Liu W., Garcia-Barcelo M.M., Sham P.C. and Khoo U.S., Estrogen receptors genetic polymorphisms risk association and their functional roles in breast cancer risk: a study on Hong Kong Chinese women, 100th American Association for Cancer Research Annual Meeting, Los Angeles, CA, USA . 2007, Abstract no. 5269. |
Chan
Y.K., Chan V.S., Chen Y., Yip S.P., Lin C.L.
and Khoo U.S., Reply to "Lack of
support for an association between CLEC |
Khoo
U.S., Liu W., Long J.R., Yip
S.P., Cheung A.N.Y., Chua D.T.T., Chan S.Y., Ngan H.Y.S., Zheng W. and Chan Y.K., The functional |
Kwong A., Wong L.P., Chan Y.K., Ma E., Khoo U.S. and Ford J.M., Reclassification of BRCA2 Unclassified Variant as Pathogenic in a Chinese Family, International Cancer Congress (13th), Hong Kong, 15 - 17 November 2006. |
Lee E.H., Chan Y.K., Nicholls J.M., Peiris J.S.M. and Khoo U.S., Sialic acid alpha-2,6-sialyltransferase (SA-alpha-2,6-Gal) Promoter Polymorphism and Gene Expression, MGH-HKU-Nature China Forum, Hong Kong. 2007. |
Liu S., Chan Y.K., Cheung A.N.Y., Liao X., Leung T.W. and Ngan H.Y.S., Expression of {Delta}Np73 and TAp73{alpha} Independently Associated with Radiosensitivities and Prognoses in Cervical Squamous Cell Carcinoma, Clinical Cancer Research . 2006, 12: 3922-7. |
Tse
Y.T., Chan Y.K., Chan S.Y., Xu M.S., Sham P.C. and Khoo U.S., Estorgen Receptors Genes and
Breast cancer Risk in Chinese: A Haplotype-based Analysis, International
Cancer Congress (13th), |
Tsun O.K.L., Yeung Y.H., Chan Y.K., Siu K.Y., Szeto E.F., Chan K.Y.Q., Chan K.W. and Cheung A.N.Y., Cervical Cytology Screening in Pregnant Women, International Cancer Congress (13th), Hong Kong, 15 - 17 November 2006. |
Yang C., Chan Y.K., Ngan H.Y.S., Khoo U.S., Chiu P.M., Chan Q.K.Y., Xue W. and Cheung A.N.Y., Single nucleotide polymorphisms of follicle-stimulating hormone receptor are associated with ovarian cancer susceptibility, Carcinogenesis. 2006, 27: 1502-6. |
Researcher
: Chan YP |
List of Research Outputs |
Ma S.K.Y., Guan X.Y., Beh S.L., Wong K.Y., Chan Y.P., Yuen H.F., Vielkind J. and Chan K.W., The significance of LMO2 expression in the progression of prostate cancer, The Journal of Pathology. 2006, 211(3): 278-85. |
Yuen
H.F., Chua C.W., Chan Y.P., Wong Y.C., Wang X. and Chan K.W., Id proteins expression in
prostate cancer: high-level expression of Id |
Yuen H.F., Chua C.W., Chan Y.P., Wong Y.C., Wang X. and Chan K.W., Significance of TWIST and E-cadherin expression in the metastatic progression of prostatic cancer, Histopathology. 2007, 50(5): 648-58. |
Yuen H.F., Chan Y.P., Wong Y.C., Wang X. and Chan K.W., The prognostic significance of Id proteins in Esophageal Squamous Cell Carcinoma, The 97th American Association of Cancer Research Annual Meeting, Los Angeles, USA, April. 2007. |
Yuen H.F., Chan Y.P., Wong M.L.Y., Kwok W.K., Chan K.K., Lee P.Y., Srivastava G., Law S.Y.K., Wong Y.C., Wang X. and Chan K.W., Upregulation of Twist in oesophageal squamous cell carcinoma is associated with neoplastic transformation and distant metastasis, Journal of Clinical Pathology. 2006, 60(5): 510-514. |
Researcher
: Chan YW |
List of Research Outputs |
Chan
T.L., Yuen S.T., Kong C.K., Chan Y.W., Chan A.S.Y., Ng W.F., Tsui W.Y., Lo M.W.S., Tam W.Y., Li V.S.W. and Leung S.Y., Heritable germline
epimutation of MSH |
Chan
T.L., Yuen S.T., Kong C.K., Chan Y.W., Chan A.S.Y. and Leung S.Y., Heritable germline
epimutation of MSH |
Chan T.L., Guo D., Yuen S.T., Chan Y.W., Chan A.S.Y. and Leung S.Y., Immunohistochemical staining on tissue microarray of colorectal cancers constitutes a convenient means to rapidly screen for MMR deficiency, The Second Biennial Scientific Meeting of the International Society for Gastrointestinal Hereditary Tumours, InSiGHT, March 27-30, 2007, Yokohama, Japan. 2007. |
Chan
T.L., Yuen S.T., Lo M.W.S., Lee T.Y.H., Kong C.K., Chan Y.W., Tsui W.Y., Li V.S.W., Chan A.S.Y. and Leung S.Y., Study of the mechanisms
underlying heritable germline epimutation of MSH |
Sheng J.Q., Chan T.L., Chan Y.W., Huang J.S., Chen J.G., Zhang M.Z., Guo X.L., Mu H., Chan A.S.Y., Li S.R., Yuen S.T. and Leung S.Y., Microsatellite instability and novel mismatch repair gene mutations in northern Chinese population with Hereditary non-polyposis colorectal cancer, Chin J Dig Dis . 2006, 7(4): 197-205. |
Researcher
: Chen WYW |
List of Research Outputs |
Chen W.Y.W., Hu X., Liang A.C.T., Au W.Y., So J.C.C., Wong M.L.Y., Shen L., Tao Q., Chu K.M., Kwong Y.L. and Srivastava G., High BCL6 expression predicts better prognosis, independent of BCL6 translocation status, translocation partner, or BCL6 deregulating mutations, in gastric lymphoma, Blood. 2006, 108: 2373-2383. |
Ying J., Li H., Murray P., Chen W.Y.W., Wang Y., Lee K.Y., Chan A.T., Ambinder R.F., Srivastava G. and Tao Q., Tumor-specific methylation of the 8p22 tumor suppressor gene DLC1 is an epigenetic biomarker for Hodgkin, nasal NK/T-cell and other types of lymphomas, Epigenetics. 2007, 2(1): 15-21. |
Researcher
: Chen Y |
List of Research Outputs |
Guo T., Wong K.Y., Chen Y. and Srivastava G., Indentification of tumor suppressor gene candidates in the commonly deleted region of chromosome 6q in extranodal NK/T-cell lymphoma, nsal type, 11th Research Postgraduate Symposium (11th RPS), The University of Hong Kong Li Ka Shing Faculty of Medicine, Hong Kong, 7 December. 2006. |
Researcher
: Cheung ANY |
Project Title: |
Stem cell related genes in gynaecological cancers |
Investigator(s): |
Cheung ANY, Ngan HYS |
Department: |
Pathology |
Source(s) of Funding: |
Small Project Funding |
Start Date: |
11/2004 |
Completion Date: |
10/2006 |
Abstract: |
To characterize the expression levels and epigenetic alterations of important stem-cell related genes in ovarian and endometrial cancers in an attempt to evaluate the roles of such genes in the their carcinogenesis; and to define useful genetic markers as predictors of clinical progression or targets for therapy. |
Project Title: |
Stem cell related genes in gestational trophoblastic diseases |
Investigator(s): |
Cheung ANY, Ngan HYS, |
Department: |
Pathology |
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
Start Date: |
01/2005 |
Abstract: |
To characterize the expression levels and epigenetic alterations of important stem-cell related genes in gestational trophoblastic disease (GTD) in an attempt to evaluate the roles of such genes in the pathogenesis of GTD; and to define useful genetic markers as predictors of clinical progression or targets for therapy. |
Project Title: |
Selecting most suitable students for production of best medical doctors-which criteria should we use? |
Investigator(s): |
Cheung ANY, Patil NG, Ip MSM, Chan LC |
Department: |
Pathology |
Source(s) of Funding: |
Leung Kau Kui Research and Teaching Endowment Fund - Teaching Grants |
Start Date: |
02/2005 |
Abstract: |
(a) enhancing the processes for evaluating and improving admission criteria for MBBS curriculum; and potentially; (b) improving curriculum design and (c) improving learning opportunities of students on ethical values and communication skills. |
Project Title: |
RAS association domain family related genes in gynaecological cancers |
Investigator(s): |
Cheung ANY, Ngan HYS, Liu VWS, |
Department: |
Pathology |
Source(s) of Funding: |
Small Project Funding |
Start Date: |
01/2006 |
Abstract: |
The purpose of the proposed investigation
are to characterize the expression levels and epigenetic alterations of RAS
association domain family related genes in ovarian and endometrial cancers in
an attempt to evaluate the roles of such genes in the their carcinogenesis;
and to define useful genetic markers as predictors of clinical progression or
targets for therapy. Key Issues and Problems being addressed: Endometrial and
ovarian cancers are two common cancers in the female genital tract and the
latter is responsible for the highest mortality in this group of cancers.
Early detection is essential since the prognosis is significantly affected by
the staging of the cancers at first diagnosis. We have earlier reported the
significant roles of a few tumour suppressor genes in gynaecological
malignancies (1-3) as an attempt to explore their application as potential
cancer markers and to better our understanding on endometrial and ovarian
cancers carcinogenesis. RASSF1 (the RAS association domain family 1) and
RASSF2 are members of a new group of RAS effectors which may function as
tumor suppressors genes and interact with the K-Ras oncogene affecting
apoptosis and cell cycle arrest (4). Whilst mutation of RASSF |
Project Title: |
Akt and p21-activated kinase signaling pathways in gestational trophoblastic disease |
Investigator(s): |
Cheung ANY, Ngan HYS, |
Department: |
Pathology |
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
Start Date: |
01/2007 |
Abstract: |
To elucidate the roles of Akt and p21-activated serine/threnonine kinases (Paks) and their related genes in the pathogenesis of gestational trophoblastic diseases; to evaluate the potential of these genes as markers for predicting clinical progression and molecular targets for therapy. |
Project Title: |
Folate and folate receptor alpha in ovarian cancers |
Investigator(s): |
Cheung ANY, |
Department: |
Pathology |
Source(s) of Funding: |
Small Project Funding |
Start Date: |
01/2007 |
Abstract: |
The project aims at investigating the
role of folate and folate receptor alpha in affecting the growth and invasive
behaviors of ovarian cancers. World wide, ovarian cancer is a common cancer
in women, contributing to the highest mortality among all gynecological
cancers. More importantly, there is a recent significant increase in the
incidence, rising from 9.8 per 100,000 (crude incidence rate) in 1999 to |
Project Title: |
Cervical cancer screening by enhanced cervical cytology-application of novel markers |
Investigator(s): |
Cheung ANY, Ngan HYS, Guan XY |
Department: |
Pathology |
Source(s) of Funding: |
Research Fund for the Control of Infectious Diseases - Full Grants |
Start Date: |
03/2007 |
Abstract: |
To explore with application of novel markers, some generated by our local genetic studies, to be detected by immunohistochemistry and ISH as an adjunct to enhance sensitivity and specificity of liquid based cervical cytology. |
List of Research Outputs |
Au
C.W.H., Siu K.Y., Liao X., Ngan H.Y.S. and Cheung A.N.Y., Tropomyosin-related
kinase B and brain-derived neurotrophic factor in ovarian cancer.
[abstract]., In: American Association for Cancer Research Annual Meeting:
Proceedings; Apr 14-18; |
Chan K.Y.Q., Ngan H.Y.S., Ip P.P.C., Liu V.W.S., Xue W. and Cheung A.N.Y., Follistatin-like 1 is important for ovarian and endometrial carcinogenesis – a differential expression and functional analysis, 98th Annual Meeting of American Association for Cancer Research, 14-18 April. 2007. |
Chan
K.Y.Q., Ngan H.Y.S., Chan Y.K., Siu K.Y., Chiu P.M., Khoo U.S., Ip P.P.C. and Cheung A.N.Y., Significance of
single nucleotide polymorphism of the metabolizing enzyme NQO |
Chan K.Y.Q., Ngan H.Y.S., Chan Y.K., Siu K.Y., Chiu P.M., Khoo U.S., Ip P.P.C. and Cheung A.N.Y., Single Nucleotide Polymorphism of Metabolizing Enzymes is Associated with Risk of Ovarian Carcinoma in Chinese Women, The 8th International Meeting on Human Genome Variation & Complex Genome Analysis, Hong Kong, 14-16 September. 2006. |
Cheung A.N.Y., Application of HPV detection and molecular markers in cervical cytology, The 48th Annual Meeting of Japanese Society of Clinical Cytology, 7-9 June. 2007. |
Cheung
A.N.Y., Application of molecular markers in
cervical cytology, The 13th Thai Japanese Workshop in Diagnostic
Cytopathology, |
Cheung
A.N.Y., Application of molecular markers in
cervical cytology, The 16th |
Cheung A.N.Y., Siu K.Y., Au W.H., Chan H.Y. and Wong E.S.Y., Follicle Stimulating Hormone can act on Receptors of Other Growth Hormones, Carcinogenesis. 2007, [Epub ahead of print]. |
Cheung
A.N.Y., Human Papilloma Virus - Updates on
Dection and Prevention, Departmental Seminar, Department of Pathology, The
|
Cheung
A.N.Y., Metastatic Tumours in Ovary, The
9th National Conference on Gynaecological Pathology, |
Cheung A.N.Y., Molecular Cytogenetics, 2007. |
Cheung A.N.Y., Molecular targets in gynaecological cancers, Pathology. 2007, 39(1): 26-45. |
Cheung
A.N.Y., Pathology of Pre-malignant glandular
lesions of uterus, Postgraduate Study Day on “Pre-malignant glandular
lesions in the female genital tract", Department of Obstetrics and
Gynaecology, The |
Cheung
A.N.Y., Recent Advances HPV Molecular Testing
& Molecular targets in gynaecological cancers, The IXth National
Gynaecological Oncology Conference, |
Cheung
A.N.Y., Recent Advances in Detection of Human
Papilloma Virus, Annual Scientific Meeting (ASM) of Hong Kong Institute of
Medical Laboratory Sciences, |
Cheung
A.N.Y., Reviews on cytology and histology, XVIIIth
FIGO World Congress, |
Cheung A.N.Y., The significance of placental and cord pathological examination in Perinatology, XVIIIth FIGO World Congress, Kuala Lumpur, Malaysia, 5-10 November. 2006. |
Cheung A.N.Y., Updates on HPV and HPV vaccine, Continuing Nursing Education (CNE) Programme, 11 May. 2007. |
Fan S.Y.S., Thomas T.M.M., Ip P.P.C. and Cheung A.N.Y., Osteoid-forming sarcoma-like mural nodule in a retroperitoneal mucinous cystadenocarcinoma, Histopathology. 2006, 49(2): 201-204. |
Ip P.P.C., Lam K.W., Yeung C.W., Pun T.C., Chan K.Y.Q. and Cheung A.N.Y., Tranexamic Acid Associated Necrosis and Intra-lesional Thrombosis of Uterine Leiomyomas: A clinicopathologic study of 490 Cases Emphasizing the Importance of Drug-induced Necrosis, Montreal IAP, 16-21 September. 2006. |
Khoo
U.S., Liu W., Long J.R., Yip
S.P., Cheung A.N.Y., Chua D.T.T., Chan S.Y., Ngan H.Y.S., Zheng W. and Chan Y.K., The functional |
Leung G.M., Woo P.S., McGhee S.M., Cheung A.N.Y., Fan S., Mang O., Thach T.Q. and Ngan H.Y.S., Age-period-cohort analysis of cervical cancer incidence in Hong Kong from 1972 to 2001 using maximum likelihood and Bayesian methods, Journal of Epidemiology and Community Health. 2006, 60: 712-720. |
Leung T.W., Siu K.Y. and Cheung A.N.Y., Differential
Expression of the Imprinting Gene IPL in Gestational Trophoblastic Diseases:
A Potentially Useful Adjunctive Tool to Differentiate Hydatidiform Moles from
Hydropic Abortions, 13th |
Leung T.W., Siu K.Y., Li A.S., Wong E.S.Y. and Cheung A.N.Y., ΔNp73 expression is a
potentially useful prognostic marker to predict development of persistent
gestational trophoblastic neoplasia requiring chemotherapy in patients
suffering from complete hydatidiform moles. [abstract]., In: American
Association for Cancer Research Annual Meeting: Proceedings; Apr 14-18; |
Liao X., Xue W.C., Shen D.H., Ngan H.Y.S., Siu K.Y. and Cheung A.N.Y., p63 expression in ovarian tumours: a marker for Brenner tumours but not transitional cell carcinomas., Histopathology. 2007, in press. |
Liu S., Chan Y.K., Cheung A.N.Y., Liao X., Leung T.W. and Ngan H.Y.S., Expression of {Delta}Np73 and TAp73{alpha} Independently Associated with Radiosensitivities and Prognoses in Cervical Squamous Cell Carcinoma, Clinical Cancer Research . 2006, 12: 3922-7. |
Luk J.M.C., Lee P.Y., Shum K.Y., Siu A.F.M., Che C.M., Tam P.C., Cheung A.N.Y., Yang Z.M., Lin Y.N., Matzuk M.M., Lee C.K.F. and Yeung W.S.B., Acrosome-Specific Gene AEP1: Identification, Characterization and Roles in Spermatogenesis , Journal of Cellular Physiology . 2006, 209: 755-766. |
Siu
K.Y., Woo N.W., Wong E.S.Y., Chan H.Y., Ngan H.Y.S. and Cheung A.N.Y., Biological
significant of p21-activated kinase |
Tam K.F., Cheung A.N.Y., Liu S., Xue W. and Ngan H.Y.S., Expression of Matrix Metalloproteinases and tissue inhibitors of metalloproteinases in atypical complex endometrial hyperplasia with and without associated malignancy, XVIII FIGO World Congress, Kuala Lumpur, Malaysia, 5-10 Nov. 2006. |
Tam K.F., Liu V.W.S., Liu S., Tsang P.C.K., Cheung A.N.Y., Yip M.W. and Ngan H.Y.S., Methylation profile in benign, borderline and malignant ovarian tumors , Journal of Cancer Research and Clinical Oncology. 2007, 133(5): 331-341. |
Tsun O.K.L., Yeung Y.H., Chan Y.K., Siu K.Y., Szeto E.F., Chan K.Y.Q., Chan K.W. and Cheung A.N.Y., Cervical Cytology Screening in Pregnant Women, International Cancer Congress (13th), Hong Kong, 15 - 17 November 2006. |
Wang Y., Liu V.W.S., Xue W., Cheung A.N.Y. and Ngan H.Y.S., Association of decreased mitochondrial DNA content with ovarian cancer progression , British Journal of Cancer. 2006, 95: 1087-1097. |
Woo N.W.S., Siu K.Y. and Cheung A.N.Y., Immunohistochemical
Analysis of Paks Expression in Ovarian Cancer, 13th |
Yang C., Chan Y.K., Ngan H.Y.S., Khoo U.S., Chiu P.M., Chan Q.K.Y., Xue W. and Cheung A.N.Y., Single nucleotide polymorphisms of follicle-stimulating hormone receptor are associated with ovarian cancer susceptibility, Carcinogenesis. 2006, 27: 1502-6. |
Researcher
: Cheung N |
List of Research Outputs |
Cheung
N., Yam
J.W.P., Chan L.C., Cleary M.L.
and So E.C.W., Identification of an
oncogene MLL fusion complex with histone methylation and acetylation
activities, 48th Annual Meeting American Society of Haematology, Orlando,
USA. December 9-12. 2006, Blood Vol 108 No. 11 Part 1: |
Researcher
: Cheung OF |
List of Research Outputs |
Wong C.M., Ng Y.L., Lee M.F., Wong C.L., Cheung O.F., Chan P.C.Y., Tung K.K., Ching Y.P. and Ng I.O.L., Tissue factor pathway inhibitor-2 as a frequently silenced tumor suppressor gene in hepatocellular carcinoma, Hepatology. 2007, 45(5): 1129-1138. |
Researcher
: Chiang AKS |
Project Title: |
Experimental immunotherapy of tumours |
Investigator(s): |
Chiang AKS |
Department: |
Paediatrics & Adolescent Med |
Source(s) of Funding: |
Research Initiation Programme |
Start Date: |
04/2001 |
Abstract: |
To develop strategies in enhancing the host immune response against tumours. |
Project Title: |
Genetic studies of tubercubosis |
Investigator(s): |
Chiang AKS |
Department: |
Paediatrics & Adolescent Med |
Source(s) of Funding: |
Other Funding Scheme |
Start Date: |
03/2002 |
Abstract: |
To host susceptibility genes in tubercubosis; to study pharmacogenomics in anti-tubercubosis drug metabolism. |
Project Title: |
Prospective study of virologic and immunologic parameters of primary Epstein-Barr virus infection in Chinese children |
Investigator(s): |
Chiang AKS, Chan KH |
Department: |
Paediatrics & Adolescent Med |
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
Start Date: |
10/2003 |
Abstract: |
An unresolved issue in EBV immunology concerns the relationship between clinical IM-like symtoms, virus DNA load and CD8+ T cell lymphocytosis; Acute IM in adolescents is associated with large expansions of EBV lytic epitope reactivities which are followed by a later expansion of latent epitope responses. The magnitude of the EBV lytic and latent epitope reactivities would be studied and compared in both IM and non-IM patients; likewise, is there a difference in the rate of emergence of latent epitope responses bewteen the IM and non -IM patients? The kinetics and evolution of the EBV epitope-specific cytotoxic T-lymphocyte (CTL) responses from primary to persistent phases of EBV infection would be compared between the two groups of children. |
Project Title: |
Prospective study of Epstein-Barr virus (EBV) strains in primary EBV infection |
Investigator(s): |
Chiang AKS |
Department: |
Paediatrics & Adolescent Med |
Source(s) of Funding: |
Small Project Funding |
Start Date: |
11/2004 |
Abstract: |
To study the occurrence of Epstein-Barr virus (EBV) diversity and coinfection in a prospective study of primary Epstein-Barr virus infection in Chinese children. |
Project Title: |
Longitudinal study of Epstein-Barr virus specific antibody responses in childhood infectious mononucleosis |
Investigator(s): |
Chiang AKS |
Department: |
Paediatrics & Adolescent Med |
Source(s) of Funding: |
Small Project Funding |
Start Date: |
12/2005 |
Abstract: |
The purpose of the proposed study is to
compare the evolution of Epstein-Barr virus (EBV) specific antibody responses
in a longitudinal followup study of symptomatic and asymptomatic primary EBV
infection. What is known about EBV antibody responses in the literature?
Epstein-Barr virus (EBV) infects greater than 90% of all human populations
and establishes a lifelong persistence within the host. Primary infections by
EBV may remain silent or induce a self-limiting lymphoproliferative disorder,
infectious mononucleosis (IM). EBV-encoded antigens are divided into those
expressed in the viral replicative cycle, i.e., the viral capsid antigen
(VCA) and the early amtigens (EA) of the diffuse (D) and the restricted (R)
varieties and those expressed in the viral latent cycle, the EBV-determined
nuclear antigen (EBNA). The different timing of emergence between the
antibodies to VCA and EA and those to EBNA indicates that the two sets of
antigens are likely expressed on separate types of cells which become
available to stimulate antibody responses under different circumstances. The
laboratory diagnosis of EBV infection is based on serological tests to detect
both specific antibodies to EBV antigens (1, 2) and heterophile antibodies
(3, 4). At the onset of symptoms of IM, the humoral response to EBV infection
is characterized by the presence of VCA IgM antibodies and the concurrent
rise of VCA IgG antibodies (5). Antibodies to diffuse early antigen
(anti-EA-D) are transitory and are detected in about 80% of infected persons.
Antibodies to EA-R may become detectable in protracted cases of the disease
after the anti-D titres have subsided. Anti-EBNA IgG can usually be detected
at a later stage at several weeks to months after the the onset of symptoms.
The majority of adult IM patients also develop IgM heterophile antibodies of
the Paul-Bunnell type but the reason for their transient emergence is
unknown. However, these heterophile antibodies are absent in the majority of
children under 4 years of age (6). The antibody responses in silent primary
EBV infections (more frequently occurred in children than adults) largely
conform to those seen in IM except that antibodies to the EA complex are
directed against R instead of D (7, 8). The early EBV-specific IgG antibody
response after primary infection is made up of low avidity antibodies. The
avidity increases in the few weeks to several months after the infection (9,
10). This property of the humoral IgG response has been employed in
serological assays to distinguish between primary and re-infection or
reactivation of different viruses such as rubella, CMV and parvovirus (11,
12, 13). Key issues: The pattern of antibody responses and the antibody
levels to EBV-encoded antigens are largely derived from cross sectional
studies of large number of individuals. Longitudinal serology data of persons
recovering from IM is seldom available and information on the humoral
response in asymptomatic EBV infection is scanty. I have followed a large
number of Chinese children presenting with infectious mononucleosis and some
children who are found to have asymptomatic primary EBV infection from the
time of onset of infection through convalescence to persistence. It offers an
opportunity to compare the natural evolution of antibody responses against
EBV in symptomatic and asymptomatic infections. Project objectives: 1. To
define the evolution of the humoral response against a human persistent
virus. 2. To study the maturation of the humoral response against a
persistent virus in terms of antibody avidity. 3. To compare the magnitude
and the quality of the humoral response against viral lytic and latent EBV
antigens from acute phase through convalescent to persistent phase in
symptomatic and asymptomatic infections. References: 1.Henle W and Henle G:
Epstein-Barr virus specific serology in immunologically compromized
individuals. Cancer Res 41: 4222-4225, 1981 2.Henle W and Henle G: Immunology
of Epstein-Barr virus. In: B, Roizman (Ed.), The Herpsesviruses, Vol. 1.
Plenum Publishing Corp., Ne York, pp 209-252, 1982 3.Paul JR and Bunnell WW:
The presence of heterophile antibodies in infecetious mononucleosis. Am J Med
Sci 183: 90-104, 1932 4.Davidsohn I and Lee CL: The clinical serology of
infectious mononucleosis. In: RL Carter and HG Penman (Eds.), Infectious
Mononucleosis. Blackwell Scientific Publications, Ltd., Oxford, pp 177-200,
1969 5.Okano M, Thiele GM, Davis JR, Grierson HL, Purtilo DT: Epstein-Barr
virus and human diseases: recent advances in disgnosis. Clin Microbiol Rev 1:
300-312, 1988 6.Sumaya CV: Infectious mononucleosis and other EBV infections:
diagnostic factors. Lab Manag 24: 37-45, 1986 7.Biggar RJ, Henle G, Bocker J,
Lennette ET, Fleisher G, Henle W: Primary Epstein-Barr virus infections in
African infacnts. II. Clinical and serological obsevations during
seroconversion. Int J cancer 22: 244-250, 1978 8.Fleisher G, Henle W, Henle
G, Lennette ET, Biggar RJ: Primary Epstein-Barr virus infection in American
infants: clinical and serological observations. J Infect Dis 139: 553-558,
1979 9.Inouye S, Hasegawa A, MAtsuno S, Katwo S: Changes in antibody avidity
after virus infections: detection by an immunosorbent assay in which a mild
protein-denaturing agent is employed. J Clin Microbiol 20: 525-529, 1984
10.Kocks C and Rajewsky K: Stepwise intracloncal maturation of antibody
affinity through somatic hypermutation. Proc Nat Acad Sci |
List of Research Outputs |
Researcher
: Ching YP |
Project Title: |
Roles and regulation of group II p21-activated protein kinases:-implications in cancer metastasis |
Investigator(s): |
Ching YP, Jin D, Ng IOL |
Department: |
Pathology |
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
Start Date: |
01/2005 |
Abstract: |
To study: (1) Characterisation of the
interaction between Pak5 and NM23 i) co-immunoprecipitation of Pak5 adn NM23
ii) defining the binding domain between Pak 5 and NM23 iii) xploring the
interaction between Pak4 adn NM23. (2) Impact of Pak5-NM23 interaction in the
biochemical properties of Pak5 and NM23 i) nucleotide diphosphate kinase
activity ii) GTPase activating activity iii) in vitro kinase activity iv)
subcellular localisation. 3) Roles of PakII in cancer metastasis using HCC as
a model i) expression profile of Pak |
Project Title: |
Roles of
p21-activated protein kinase (Pak) |
Investigator(s): |
Ching YP |
Department: |
Pathology |
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
Start Date: |
07/2005 |
Abstract: |
To characterize the overexpression of
Pak1 protein and its activities in human HCC; to delineate the signaling
pathways mediated by Pak |
Project Title: |
Roles of
p21-activated protein kinase (Pak) |
Investigator(s): |
Ching YP, Ng IOL, Jin D, Yau TO |
Department: |
Pathology |
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
Start Date: |
01/2006 |
Abstract: |
(1) To characterize the mechanisms
leading to Pak1 overexpression in human HCC; (2) to delineate the roles of
Pak |
Project Title: |
Functional characterization of a putative tumour suppressor, AMP-activated protein kinase, in liver cancer |
Investigator(s): |
Ching YP |
Department: |
Pathology |
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
Start Date: |
02/2006 |
Abstract: |
Purpose of study Liver cancer
(hepatocellular carcinoma, HCC) is one of the most common cancers in the
world, especially in Asia and Africa, and is the third most common fatal
cancer in |
Project Title: |
Molecular
neurobiology: Regulation of p21-activated protein kinase |
Investigator(s): |
Ching YP |
Department: |
Anatomy |
Source(s) of Funding: |
Matching Fund for NSFC Young Researcher Award |
Start Date: |
01/2007 |
Completion Date: |
12/2009 |
Abstract: |
To study molecular neurobiology:
regulation of p21-activated protein kinase |
Project Title: |
Functional characterisation of a putative tumor suppressor gene, TAX1BP2, in liver cancer |
Investigator(s): |
Ching YP |
Department: |
Pathology |
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
Start Date: |
04/2007 |
Abstract: |
1. Key issues and problem being
addressed: Liver cancer (hepatocellular carcinoma, HCC) is one of the most
common cancers worldwide. The prognosis of HCC patients is often poor because
of the delay in diagnosis and its high recurrence rate after surgery.
Although the risk factors of HCC, such as hepatitis B and C virus infection,
cirrhosis, and dietary aflatoxin are well established, the genetic mechanisms
in the pathogenesis and tumour progression are poorly defined. Chromosome
instability that leads to clonal expansion of genetically altered cells is a
hallmark of cancer and is highly relevant to hepatocarcinogenesis. Thus
characterization of tumor suppressor genes and elucidation of the mechanisms
of chromosome instability are both major challenges in liver cancer research.
2. Purpose of proposed project: Recently, we have identified and
characterized a novel cellular centrosomal protein, which we have named
TAX1BP2 (Ching et al., 2006, Nature cell Biology 8: 717-24). We have
demonstrated that TAX1BP2 plays an important role in the regulation of
centrosome duplication, and dysregulation of TAX1BP2 may lead to aneuplody of
cells. In our preliminary study, we observed that TAX1BP2 is frequently
underexpressed in human HCC (40%) and the underexpression of TAX1BP2
transcript is significantly associated with a poorer prognosis in terms of
shorter overall survival rates. In addition, TAX1BP2 is localized at the
chromosome locus 1p36, which is also a frequently deleted region in HCC. As
HBV infection is a major risk factor of HCC, particularly in this region and
locally, we have found that the HBV viral oncoprotein HBx interacts with
TAX1BP |
List of Research Outputs |
Chan D.W., Chan P.C.Y., Yam J.W.P., Ching Y.P. and Ng I.O.L., Prickle-1 negatively regulates wnt/beta-catenin pathway by promoting dishevelled ubiquitination/degradation in liver cancer, Gastroenterology. USA, Elsevier Inc, 2006, 131: 1218-1227. |
Ching Y.P., Frontiers in Biomedical Research, Chromosome instability and cancer. 2006. |
Ching
Y.P., Leong
V.Y.L., Lee M.F. and Ng I.O.L., Pak1 overexpression is
important in the metastasis of hepatocellular carcinoma, Queenstown
Molecular Biology |
Ching Y.P., Chan S.F., Jeang K.T. and Jin D., Retroviral oncoprotein Tax targets coiled-coil centrosomal protein TAX1BP2 to induce centrosome overduplication., Nature Cell Biology. 2006, 8: 717-724. |
Hui
C.F., Yau T.O., Ching Y.P. and Ng I.O.L., Rapamycin and CCI-779 suppress
the growth of hepatocellular carcinoma cells, Proceedings of the Annual
Meeting of American Association for Cancer Research, |
Leung
T.H.Y., Ching Y.P., Yam J.W.P. and Ng I.O.L., DLC2 (deleted in liver cancer
2) suppresses cell growth via the regulation of p70S6K, Queenstown
Molecular Biology |
Li H., Fung K.L., Jin D., Chung S.S.M., Ching Y.P., Ng I.O.L., Sze K.H., Ko C.B. and Sun H., Solution Structures, Dynamics, and Lipid-binding of the Sterile a-Motif Domain of the Deleted in Liver Cancer 2, PROTEINS: Structure, Function, and Bioinformatics. 2007, 67: 1154-1166. |
Wong C.L., Ching Y.P. and Ng I.O.L., Roles and regulations of Rho-kinases in hepatocellular carcinoma, Proceedings of the Annual Meeting of American Association for Cancer Research, Los Angeles, USA, April. 2007. |
Wong C.M., Ng Y.L., Lee M.F., Wong C.L., Cheung O.F., Chan P.C.Y., Tung K.K., Ching Y.P. and Ng I.O.L., Tissue factor pathway inhibitor-2 as a frequently silenced tumor suppressor gene in hepatocellular carcinoma, Hepatology. 2007, 45(5): 1129-1138. |
Researcher
: Chiu PM |
List of Research Outputs |
Chan
K.Y.Q., Ngan H.Y.S., Chan Y.K., Siu K.Y., Chiu P.M., Khoo U.S., Ip P.P.C. and Cheung A.N.Y., Significance of single
nucleotide polymorphism of the metabolizing enzyme NQO |
Chan K.Y.Q., Ngan H.Y.S., Chan Y.K., Siu K.Y., Chiu P.M., Khoo U.S., Ip P.P.C. and Cheung A.N.Y., Single Nucleotide Polymorphism of Metabolizing Enzymes is Associated with Risk of Ovarian Carcinoma in Chinese Women, The 8th International Meeting on Human Genome Variation & Complex Genome Analysis, Hong Kong, 14-16 September. 2006. |
Yang C., Chan Y.K., Ngan H.Y.S., Khoo U.S., Chiu P.M., Chan Q.K.Y., Xue W. and Cheung A.N.Y., Single nucleotide polymorphisms of follicle-stimulating hormone receptor are associated with ovarian cancer susceptibility, Carcinogenesis. 2006, 27: 1502-6. |
Researcher
: Chung LP |
List of Research Outputs |
Lam C.L., Girard L., Suen W.S., Chung L.P., Tin P.C., Lam W.K., Minna J.D. and Wong M.P., Establishment and expression profiling of new lung cancer cell lines from Chinese smokers and life-time never-smokers, Journal of Thoracic Oncology. 2006, 1: 932-942. |
Lam C.L., Girard L., Ramirez R., Chau W.S., Suen W.S., Sheridan S., Tin V.P., Chung L.P., Wong M.P., Shay J.W., Gazdar A.F., Lam W.K. and Minna J.D., Expression of nicotinic acetylcholine receptor subunit genes in non small cell lung cancer reveals differences between smokers and nonsmokers, Cancer Research. 2007, 67(10): 4638-4647. |
Lam C.L., Girard L., Ramirez R., Chau W.S., Suen W.S., Sheridan S., Tin V.P.C., Chung L.P., Wong M.P., Shay J.W., Gazdar A.F., Lam W.K. and Minna J.D., Nicotinic acetylcholine receptor subunit genes showed difference in expression pattern in smokers and nonsmokers , Annual Meeting of the American Association of Cancer Research. 2007, AACR abstracts: 2430. |
Leung L.H., Chung L.P., Tam Y.S.I., Tin P.C. and Wong M.P., Src kinase pathway is a potential candidate for molecular targeted therapy of non-small cell lung cancers (NSCLC) that show exon 19 deletion mutation or other epidermal growth factor (EGFR) abnormalities., AACR annual meeting 2007, Los Angeles, CA. 2007, 301. |
Leung L.H., Chung L.P. and Wong M.P., Src kinase pathway is a potential candidate for molecular targeted therapy of non-small cell lung cancers (NSCLC) that show exon 19 deletion mutation or other epidermal growth factor receptor (EGFR) abnormalities , American Association for Cancer Research Annual Meeting, Los Angeles, California, the United State . 2007. |
Leung L.H., Chung L.P. and Wong M.P., Src kinase-a potential drug target in treating non-small cell lung cancer (NSCLC), 1st Annual John R. Murren Memorial Symposium: Advances in Thoracic Oncology, Yale Continuing Medical Education and Nevada Cancer Institute, Las Vegas, Nevada, USA . 2007. |
Tam
Y.S.I., Leung L.H., Chung L.P. and Wong M.P., EGFR with L858R and H870R
double mutations showed reduced sensitivity to Gefitinib., AACR annual
meeting 2007, |
Tam Y.S.I., Leung L.H., Chung L.P. and Wong M.P., Germline EGFR mutation is uncommon and plays a limited role in predisposition to lung cancer., AACR annual meeting 2007, Los Angeles, CA. 2007, 32. |
Researcher
: Collins RJ |
List of Research Outputs |
Ng D.S., Chok K.S., Law W.L., Collins R.J. and Fan S.T., Long-term survival after resection of extrahepatic recurrence of hepatocellular carcinoma at the right colon, International Journal of Colorectal Disease. 2006, 22(11): 1411-1412. |
Researcher
: Fan SYS |
List of Research Outputs |
Fan S.Y.S., Thomas T.M.M., Ip P.P.C. and Cheung A.N.Y., Osteoid-forming sarcoma-like mural nodule in a retroperitoneal mucinous cystadenocarcinoma, Histopathology. 2006, 49(2): 201-204. |
Researcher
: Guo D |
List of Research Outputs |
Chan T.L., Guo D., Yuen S.T., Chan Y.W., Chan A.S.Y. and Leung S.Y., Immunohistochemical staining on tissue microarray of colorectal cancers constitutes a convenient means to rapidly screen for MMR deficiency, The Second Biennial Scientific Meeting of the International Society for Gastrointestinal Hereditary Tumours, InSiGHT, March 27-30, 2007, Yokohama, Japan. 2007. |
Guo D., Yuen S.T., Tsui W.Y., Chan A.S.Y., Chan T.L. and Leung S.Y., Expression of wnt signaling target genes in colorectal cancer progression, Proceedings of the 98th Annual Meeting of the American Association for Cancer Research. 2007. |
Researcher
: Guo T |
List of Research Outputs |
Guo T., Wong K.Y., Chen Y. and Srivastava G., Indentification of tumor suppressor gene candidates in the commonly deleted region of chromosome 6q in extranodal NK/T-cell lymphoma, nsal type, 11th Research Postgraduate Symposium (11th RPS), The University of Hong Kong Li Ka Shing Faculty of Medicine, Hong Kong, 7 December. 2006. |
Researcher
: Hawkins BR |
List of Research Outputs |
Au W.Y., Fung T.K., Ma E.S.K., Shek T.W.H., Hawkins B.R. and Liang R.H.S., HLA associations, microsatellite instability and epigenetic changes in thyroid lymphoma in Chinese, Leuk Lymphoma. 2007, 48(3): 531-534. |
Researcher
: Hu X |
List of Research Outputs |
Chen W.Y.W., Hu X., Liang A.C.T., Au W.Y., So J.C.C., Wong M.L.Y., Shen L., Tao Q., Chu K.M., Kwong Y.L. and Srivastava G., High BCL6 expression predicts better prognosis, independent of BCL6 translocation status, translocation partner, or BCL6 deregulating mutations, in gastric lymphoma, Blood. 2006, 108: 2373-2383. |
Researcher
: Huang F |
Project Title: |
Functional conditioning of dendritic cells for DC-based tumor vaccine |
Investigator(s): |
Huang F, Tian L, Ng IOL |
Department: |
Pathology |
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
Start Date: |
01/2003 |
Abstract: |
Dendritic cell (DC)-based tumor vaccine is a newly developed therapeutic approach for cancer treatment. It aims to promote specific immunity to cancer cells within tumor bearing individuals. Recent studies reveal that DC are not a homogenous population, and their ability to provide activation signals can vary significantly between different DC subtypes, lineages or maturity. The types and functional conditions, hence the immunogenic 'quality', of the DC employed are understandably essential. This project is to examine critically the roles of co-stimulatory molecules in DC-based tumor vaccines. The main objective is to develop immunologically active and programmable DC-tumor vaccines with high efficacy useful in cancer therapies. |
Project Title: |
Mechanisms for the induction and regulation of autoimmune responses by dendritic cells and T regulatory cells in systemic lupus erythematosus |
Investigator(s): |
Huang F, Wu AYY, Tian L |
Department: |
Pathology |
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
Start Date: |
12/2003 |
Abstract: |
To study the mechanisms for induction and regulation of autoimmune responses; to study effects of cell death on the induction of anti-nuclear antibody production, in normal and in autoimmune-prone mice; to test the hypothesis that uptake of necrotic or apoptotic dying cells by dendritic cells may differentially regulate autoimmune responses in vivo; to determine the roles, and mechanisms for generation, of the naturally occurring T regulatory cells in autoimmune and non-autoimmune mice. |
Project Title: |
Molecular characterization of dendritic cells functionally modulated by dying cells - mechanism for the induction and regulation of autoimmune responses by dendritic cells (II) |
Investigator(s): |
Huang F, Leung SY, Wu AYY, Tian L |
Department: |
Pathology |
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
Start Date: |
01/2005 |
Abstract: |
To study the molecular mechanisms for the induction of autoimmune responses by DCs; to study the immune response profiles of DCs after uptake of dying cells; to determine how DC functional properties can be differentially modulated following uptake of apoptotic and necrotic dying cells; to determine the therapeutic potential of functionally conditioned DC for a possible long-term rectification of the autoimmune disorder. |
Project Title: |
Mechanistic assessment of autoimmune responses induced by dendritic cells in interleukin-10 deficient mice - implications in lupus pathogenesis |
Investigator(s): |
Huang F |
Department: |
Pathology |
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
Start Date: |
01/2007 |
Abstract: |
To define the role of IL |
List of Research Outputs |
Hui
C.K., Zhang H., Lee P.Y., Marin H., Yueng Y.H., Leung K.W., Lu L., Leung N., Luk J.M.C., Naoumov N., Huang F. and Lau G., Role of regulatory T cells in
natural immunity and sustained pharmacological control hepatitis B infection,
The Liver Meeting of The American Association for the Study of Liver, Hepatology.
2006, 44: |
To
K.W., Wong O.H., Li H.B., Chen
S.F., Lo C.K., Chiang A.K.S. and Huang F., Effects Of Bergapten On
Dendritic Cell Functions, The 9th International Syposium on Dendritic
Cells, |
To K.W., Wong O.H., Li H.B., Chen S.F., Lo C.K., Chiang A.K.S. and Huang F., Immunomodulatory effects
of Bergapten on dendritic cell functions, 9th
International Conference on Dendritic Cell, |
Researcher
: Hui CF |
List of Research Outputs |
Hui C.F., Yau T.O., Ching Y.P. and Ng I.O.L., Rapamycin and CCI-779 suppress
the growth of hepatocellular carcinoma cells, Proceedings of the Annual
Meeting of American Association for Cancer Research, |
Researcher
: Ip PPC |
List of Research Outputs |
Chan K.Y.Q., Ngan H.Y.S., Ip P.P.C., Liu V.W.S., Xue W. and Cheung A.N.Y., Follistatin-like 1 is important for ovarian and endometrial carcinogenesis – a differential expression and functional analysis, 98th Annual Meeting of American Association for Cancer Research, 14-18 April. 2007. |
Chan
K.Y.Q., Ngan H.Y.S., Chan Y.K., Siu K.Y., Chiu P.M., Khoo U.S., Ip P.P.C. and Cheung A.N.Y., Significance of single
nucleotide polymorphism of the metabolizing enzyme NQO |
Chan K.Y.Q., Ngan H.Y.S., Chan Y.K., Siu K.Y., Chiu P.M., Khoo U.S., Ip P.P.C. and Cheung A.N.Y., Single Nucleotide Polymorphism of Metabolizing Enzymes is Associated with Risk of Ovarian Carcinoma in Chinese Women, The 8th International Meeting on Human Genome Variation & Complex Genome Analysis, Hong Kong, 14-16 September. 2006. |
Fan S.Y.S., Thomas T.M.M., Ip P.P.C. and Cheung A.N.Y., Osteoid-forming sarcoma-like mural nodule in a retroperitoneal mucinous cystadenocarcinoma, Histopathology. 2006, 49(2): 201-204. |
Ip P.P.C., Lam K.W., Yeung C.W., Pun T.C., Chan K.Y.Q. and Cheung A.N.Y., Tranexamic Acid Associated Necrosis and Intra-lesional Thrombosis of Uterine Leiomyomas: A clinicopathologic study of 490 Cases Emphasizing the Importance of Drug-induced Necrosis, Montreal IAP, 16-21 September. 2006. |
Researcher
: Jones BM |
List of Research Outputs |
Kwok J.S.Y., Jones B.M., Lee T.L., Yau Y.S. and Lau Y.L., A young man with unusually severe eczema since childhood, Hong Kong Journal of Paediatrics (New Series). 2006, 11: 229-232. |
Researcher
: Khoo |
Project Title: |
Association of the pro-inflammatory and anti-inflammatory cytokine gene polymorphism to breast cancer susceptibility |
Investigator(s): |
Khoo |
Department: |
Pathology |
Source(s) of Funding: |
Small Project Funding |
Start Date: |
11/2003 |
Abstract: |
To determine whether the genetic variants of the pro-inflammatory and anti-inflammatory cytokines may (a) contribute towards breast cancer susceptibility or (b) influence prognosis; to investigate whether the joint effects of several of these alleles and/or in combination of specific environmental factors may contribute towards a stronger association. |
Project Title: |
Promoter polymorphisms of BRCA1: genetic association and functional study |
Investigator(s): |
Khoo |
Department: |
Pathology |
Source(s) of Funding: |
Small Project Funding |
Start Date: |
11/2004 |
Abstract: |
To perform a case-control study to investigate the promoter polymorphisms BRCA1 gene for risk association to breast cancer; to test by Luciferase report assay whether these promoter SNPs result in functional alteration of the BRCA1 gene. |
Project Title: |
Role of Polymorphisms of the Inflammatory Response Genes and DC-SIGNR in Genetic Susceptibility to SARS and other infections. |
Investigator(s): |
Khoo US, Altmeyer RM, |
Department: |
Pathology |
Source(s) of Funding: |
Research Fund for the Control of Infectious Diseases - Full Grants |
Start Date: |
12/2004 |
Abstract: |
To determine whether (i) SNPs of the inflammatory response genes may contribute in determining susceptibilty, response to treatment and clinical outcome of SARS.(ii) Heterozygous genotypes of DC-SIGNR may influence binding affinity for viral glycopeptides, namely S1 of SARS, E2 of HCV and gp120 of HIV. |
Project Title: |
Infectious Diseases and Global Health: Genetic approach to the identification of host susceptibility factors and pathogen virulence determinants. Genetics of coronaviruses-associated acute respiratory disease |
Investigator(s): |
Khoo |
Department: |
Pathology |
Source(s) of Funding: |
CGDN NCE Large Scale Collaborative Research Grant |
Start Date: |
02/2005 |
Abstract: |
To study association of SARS-susceptibility with MHC and KIR; to carry out genetic and functional analysis of coronavirus-associated respiratory disease. |
Project Title: |
The role of
L-SIGN (CD |
Investigator(s): |
Khoo |
Department: |
Pathology |
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
Start Date: |
07/2005 |
Abstract: |
Previously we have been able to show that L_SIGN polymorphism determines the susceptibility for SARS infection. We are also to show that L-SIGN is expressed in alveolar epithelium of the healthy lung tissues, with or without co-expression of ACE2. Furthermore, L-SIGN is also expressed in the ACE2(+) alveolar epithelium of the lung of fatal SARS patients, strongly suggesting the L-SIGN may be involved in SARS pathogenesis. It has also been shown that ACE2 has been found to be expressed in the lung and small bowel enterocytes of normal individuals. In this study we intend to address specific question as below: (1) is LSIGN also expressed in the small bowel of normal individuals and SARS infected patients? (2) What is the specific role of L-SIGN in the binding and replication of SARS CoV in the setting of primary respiratory exposure/infection? - does it facilitate SARS CoV infection of permissive cells in trans or in cis, or both? (3) What is the difference in binding affinity between homozygous and heterozygous L-SIGN expression in vitro and in vivo? And how does this different account for the difference in SARS susceptibility? (4) From dbSNP (http://www.ncbi.nlm.nih.gov/SNP/), there is 12 ACE2 single nucleoride polymorphisms (SNPs) located in the coding exons, introns and promoter regions, of which four SNPs has been found with a minor allele frequency greater than 5% in our population and thus were suitable for further analysis. So we also would like to know if ACE2 SNPs is associated with different susceptibility for SARS infection. |
Project Title: |
Gene-based and haplotype analysis of the estrogen receptor genes for breast cancer susceptibility |
Investigator(s): |
Khoo |
Department: |
Pathology |
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
Start Date: |
01/2006 |
Abstract: |
To identify all possible risk-conferring variations within these genes by direct sequencing of the promoter region, all exons and rrelevant exon-intron junctions on 90 unrelated individuals; to examine the pattern of linkage disequilibrium (LD) between SNPs on the genes, and hence haptotype tagging SNPs (htSNP) for risk association study; to assess the combined effect of these ER-α and ER-α htSNPs on risk of breast cancer in a large Chinese case-control population of at least 2,000 case-control pairs. |
Project Title: |
The functional role of ICAM3 polymorphism in genetic susceptibility to SARS infection |
Investigator(s): |
Khoo US, Chan YK, Leung GM, Lin CL, Lim WWL, Peiris JSM, Sham PC, Tam PKH, Garcia-Barcelo MM, Yip SP |
Department: |
Pathology |
Source(s) of Funding: |
Research Fund for the Control of Infectious Diseases - Full Grants |
Start Date: |
01/2006 |
Abstract: |
To confirm our genetic association findings by a large case-control study and a family-based association study with family members as controls; to perform functional studies to investigate the role of ICAM3 polymorphisms in influencing the initiation of immune response to SARS-CoV infection. |
Project Title: |
Promoter polymorphisms of L-SIGN in relation to host genetic susceptibility to SARS. |
Investigator(s): |
Khoo |
Department: |
Pathology |
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
Start Date: |
02/2006 |
Abstract: |
Objective of study : 1. To identify the
possible variants in the promoter region of L-SIGN by direct sequencing of 30
unrelated normal Chinese individuals. 2. To examine the pattern of linkage
disequilibrium (LD) between all the variants identified, and hence select
haptotype tagging single nucleotide polymorphism (htSNP) for risk association
study. 3. To analyze these htSNPs for genetic association to SARS CoV using a
large case-control study. 4. To examine for possible LD between the htSNPs
and the tandem-neck repeats polymorphisms of L-SIGN previously genotyped. 5.
To perform in-vitro functional studies to confirm the effect of L-SIGN
promoter SNPs on the transcriptional activity of the promoter. Key issues and
problems being addressed: L-SIGN or DC-SIGNR (CD |
Project Title: |
Promoter polymorphisms of DC-SIGN in relation to host genetic susceptibility to SARS infection. |
Investigator(s): |
Khoo US, Chan YK, Leung GM, Lin CL, Lim WWL, Peiris JSM, Sham PC, Tam PKH, Cheung ANY, Yip SP |
Department: |
Pathology |
Source(s) of Funding: |
Research Fund for the Control of Infectious Diseases - Full Grants |
Start Date: |
06/2006 |
Abstract: |
I. To analyze the promoter SNPs of DC-SIGN for genetic association to SARS CoV using a large case-control study and a family-based association study II. To perform in-vitro functional studies to confirm the effect of DC-SIGN promoter SNPs on promoter activity and its influence on DC-SIGN mediated transmission of SARS CoV to target cells. |
Project Title: |
Splice variant expression in relation to Estrogen Receptor gene expression in Chinese breast cancer |
Investigator(s): |
Khoo |
Department: |
Pathology |
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
Start Date: |
03/2007 |
Abstract: |
Breast cancer is the commonest cause of
cancer in women. Its incidence in Hong Kong Chinese has been steadily rising
in the last few decades, with age-standardised rates now at 42.6 per 100,000
which although lower than Caucasian rates, is the highest rate reported in |
List of Research Outputs |
Chan
K.Y.Q., Ngan H.Y.S., Chan Y.K., Siu K.Y., Chiu P.M., Khoo U.S., Ip P.P.C. and Cheung A.N.Y., Significance of single
nucleotide polymorphism of the metabolizing enzyme NQO |
Chan K.Y.Q., Ngan H.Y.S., Chan Y.K., Siu K.Y., Chiu P.M., Khoo U.S., Ip P.P.C. and Cheung A.N.Y., Single Nucleotide Polymorphism of Metabolizing Enzymes is Associated with Risk of Ovarian Carcinoma in Chinese Women, The 8th International Meeting on Human Genome Variation & Complex Genome Analysis, Hong Kong, 14-16 September. 2006. |
Chan Y.K., Tse Y.T., Chan S.Y., Liu W., Garcia-Barcelo M.M., Sham P.C. and Khoo U.S., Estrogen receptors genetic polymorphisms risk association and their functional roles in breast cancer risk: a study on Hong Kong Chinese women, 100th American Association for Cancer Research Annual Meeting, Los Angeles, CA, USA . 2007, Abstract no. 5269. |
Chan
Y.K., Chan V.S., Chen Y., Yip S.P., Lin C.L. and Khoo U.S., Reply to "Lack of
support for an association between CLEC |
Fan Y.S., Khoo U.S. and Chan G.S.W., A retroperitoneal immature teratoma with rhabdomyoblastic and nephroblastic differentiation., Pathology. 2006, 38(4): 364-7. |
Khoo
U.S., Estrogen Receptors Genes and Breast
Cancer Risk in the Chinese Population., Croucher Advanced Study Institute,
|
Khoo
U.S., Estrogen Receptors Genes and Breast
Cancer Risk in the Chinese Population, Croucher Advanced Study Institute, |
Khoo
U.S., Genetic susceptibility to SARS
coronavirus infection - the protective role of homozygous L-SIGN, 11th
International Symposium of the Society of Chinese Bioscientists in |
Khoo
U.S., Genetic susceptibility to SARS
coronavirus infection - the protective role of homozygous L-SIGN, Proceedings
of the Society of Chinese Bioscientists in |
Khoo
U.S., The BRCA and Estrogen Receptor genes in
breast cancer susceptibility, 5th |
Khoo
U.S., The BRCA and Estrogen Receptor genes in
breast cancer susceptibility, 5th |
Khoo
U.S., Liu
W., Long J.R., Yip S.P., Cheung
A.N.Y., Chua D.T.T., Chan S.Y., Ngan H.Y.S., Zheng W. and Chan Y.K., The functional |
Kwong A., Wong L.P., Chan Y.K., Ma E., Khoo U.S. and Ford J.M., Reclassification of BRCA2 Unclassified Variant as Pathogenic in a Chinese Family, International Cancer Congress (13th), Hong Kong, 15 - 17 November 2006. |
Lee E.H., Chan Y.K., Nicholls J.M., Peiris J.S.M. and Khoo U.S., Sialic acid alpha-2,6-sialyltransferase (SA-alpha-2,6-Gal) Promoter Polymorphism and Gene Expression, MGH-HKU-Nature China Forum, Hong Kong. 2007. |
Tse
Y.T., Chan Y.K., Chan S.Y., Xu M.S., Sham P.C. and Khoo U.S., Estorgen Receptors Genes
and Breast cancer Risk in Chinese: A Haplotype-based Analysis, International
Cancer Congress (13th), |
Yang C., Chan Y.K., Ngan H.Y.S., Khoo U.S., Chiu P.M., Chan Q.K.Y., Xue W. and Cheung A.N.Y., Single nucleotide polymorphisms of follicle-stimulating hormone receptor are associated with ovarian cancer susceptibility, Carcinogenesis. 2006, 27: 1502-6. |
Researcher
: Ko CF |
List of Research Outputs |
Yam J.W.P., Ko C.F., Chan C.Y., Jin D. and Ng I.O.L., Interaction of DLC1-tensin2 complex with caveolin-1 and implications in tumor suppression, Cancer Research. 2006, 66: 8367-8372. |
Yam J.W.P., Ko C.F., Chan C.Y., Yau T.O., Tung K.K., Leung T.H.Y., Jin D. and Ng I.O.L., Tensin2 variant 3 is associated with aggressive tumor behavior in human hepatocellular carcinoma, Hepatology. 2006, 44: 881-890. |
Yam J.W.P., Ko C.F., Chan P.C.Y., Yau T.O., Tung K.K., Leung T.H.Y., Jin D. and Ng I.O.L., Tensin2 variant 3 is associated with aggressive tumor behavior in human hepatocellular carcinoma, Queenstown Signal Transduction Meeting, New Zealand. 2006. |
Researcher
: Ko KH |
List of Research Outputs |
Ko K.H., Lam Q.L.K., Zhang M., Wong C.K.Y., Lo K.C., Kahmeyer-Gabbe M., Tsang W.H., Tsang S.L., Chan L.C., Sham M.H. and Lu L., Hoxb3 deficiency impairs B lymphopoiesis in mouse bone marrow, Experimental Hematology. 2007, 35(3): 465-75. |
Lam Q.L.K., Lo C.K., Zheng B., Ko K.H., Osmond D.G., Wu G.E., Rottapel R. and Lu L., Impaired V(D)J recombination and increased apoptosis among B cell precursors in the bone marrow of c-Abl-deficient mice., International Immunology. 2007, 19(3): 267-76. |
Yang M.X., Qu X., Kong B.H., Lam Q.L.K., Shao Q.Q., Deng B.P., Ko K.H. and Lu L., Membrane type 1-matrix metalloproteinase is involved in the migration of human monocyte-derived dendritic cells, Immunology and Cell Biology. 2006, 84(6): 557-62. |
Researcher
: Kwok JSY |
List of Research Outputs |
Kwok J.S.Y., Jones B.M., Lee T.L., Yau Y.S. and Lau Y.L., A young man with unusually severe eczema since childhood, Hong Kong Journal of Paediatrics (New Series). 2006, 11: 229-232. |
Leung A.Y.H., Chow C.H., Kwok J.S.Y., Lui C.K., Cheng V.C.C., Yuen K.Y., Lie A.K.W. and Liang R.H.S., Safety of vacinating sibling donors with live-attenuated varicella zoster vaccine before hematopoietic stem cell transplantation, Bone Marrow Transplantation. 2007, 39(11): 661-5. |
Researcher
: Lam CCK |
List of Research Outputs |
Au
W.Y., Fung T.K., Lie A.K.W., Lam K.Y., Lam C.C.K. and Kwong Y.L., Reemergence of JAK2 V |
So J.C.C., Wan T.S.K., Yip S.F., Ma E.S.K., Lam C.C.K. and Chan L.C., Can morphological assessment limit the use of specific genetic testing to exclude chronic myeloid leukaemia?, Br J Haematol. 2007, 137(4): 377. |
Researcher
: Lam CL |
List of Research Outputs |
Lam
B., Lam C.L. and Ip M.S.M., Obstructive sleep apnoea in |
Lam B., Sam K., Mok W.Y.W., Cheung M.T., Fong D.Y.T., Lam J.C.M., Lam C.L., Yam L.Y.C. and Ip M.S.M., Randomized study of three non-surgical treatments in mild to moderate obstructive sleep apnea, Thorax. 2007, 62: 354-359. |
Lam B., Wong M.P., Fung S.L., Lam C.L., Wong P.C., Wong T.Y.W., Lam F.M., Ip M.S.M., Ooi C.G.C. and Lam W.K., The clinical value of autofluorescence bronchoscopy for the diagnosis of lung cancer , European Respiratory Journal. 2006, 28(5): 915-919. |
Lam B., Sam K., Lam J.C., Lam C.L., Ku P.P. and Ip M.S.M., The efficacy of oral appliance in the treatment of severe obstructive sleep apnea, American Thoracic Society International Conference, San Francisco, USA. American Jouranl of Respiratory and Critical Care Medicine. 2007, 175: A708. |
Lam C.L., Girard L., Suen W.S., Chung L.P., Tin P.C., Lam W.K., Minna J.D. and Wong M.P., Establishment and expression profiling of new lung cancer cell lines from Chinese smokers and life-time never-smokers, Journal of Thoracic Oncology. 2006, 1: 932-942. |
Lam C.L., Girard L., Ramirez R., Chau W.S., Suen W.S., Sheridan S., Tin V.P., Chung L.P., Wong M.P., Shay J.W., Gazdar A.F., Lam W.K. and Minna J.D., Expression of nicotinic acetylcholine receptor subunit genes in non small cell lung cancer reveals differences between smokers and nonsmokers, Cancer Research. 2007, 67(10): 4638-4647. |
Lam C.L., Girard L., Ramirez R., Chau W.S., Suen W.S., Sheridan S., Tin V.P.C., Chung L.P., Wong M.P., Shay J.W., Gazdar A.F., Lam W.K. and Minna J.D., Nicotinic acetylcholine receptor subunit genes showed difference in expression pattern in smokers and nonsmokers , Annual Meeting of the American Association of Cancer Research. 2007, AACR abstracts: 2430. |
Lam C.L. and Cheung B.M.Y., Update on levofloxacin (cravit): focus on respiratory infectious, Medical Progress. 2007, 1: 31-36. |
Lam J.C., Lam C.L., Xu A., Yan S.W., Lam B., Lam K.S.L. and Ip M.S.M., Serum adipocyte-fatty acid binding protein (AFABP) level correlates with the duration of oxygen desaturation in obstructive sleep apnea (OSA) patients, American Thoracic Society International Conference, San Francisco, USA 2007. American Journal of Respiratory and Critical Care Medicine. 2007, 175: A55. |
Mohan A., Bollineni S., Lam B., Lam C.L. and Ip M.S.M., Obstructive sleep apnoea in |
Shames D.S., Girard L., Gao B., Sato M., Lewis C.M., Shivapurkar N., Jiang A., Perou C.M., Kim Y.H., Pollack J.R., Fong K.M., Lam C.L., Wong M.P., Shyr Y., Nanda R., Olopade O.I., Gerald W., Euhus D.M., Shay J.W., Gazdar A.F. and Minna J.D., A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies, PLoS Med. 2006, 3(12): e486. |
Researcher
: Lam QLK |
List of Research Outputs |
Ko K.H., Lam Q.L.K., Zhang M., Wong C.K.Y., Lo K.C., Kahmeyer-Gabbe M., Tsang W.H., Tsang S.L., Chan L.C., Sham M.H. and Lu L., Hoxb3 deficiency impairs B lymphopoiesis in mouse bone marrow, Experimental Hematology. 2007, 35(3): 465-75. |
Lam Q.L.K., Lo C.K., Zheng B., Ko K.H., Osmond D.G., Wu G.E., Rottapel R. and Lu L., Impaired V(D)J recombination and increased apoptosis among B cell precursors in the bone marrow of c-Abl-deficient mice., International Immunology. 2007, 19(3): 267-76. |
Lam Q.L.K., Liu S., Cao X. and Lu L., Involvement of leptin signaling in the survival and maturation of bone marrow-derived dendritic cells, European Journal of Immunology. 2006, 36(12): 3118-30. |
Lam Q.L.K. and Lu L., Role of leptin in immunity, Cell Mol Immunol. 2007, 4(1): 1-13. |
Yang M.X., Qu X., Kong B.H., Lam Q.L.K., Shao Q.Q., Deng B.P., Ko K.H. and Lu L., Membrane type 1-matrix metalloproteinase is involved in the migration of human monocyte-derived dendritic cells, Immunology and Cell Biology. 2006, 84(6): 557-62. |
Researcher
: Lee KW |
Project Title: |
Identification of novel plasma RNA biomarkers of nasopharyngeal carcinoma for early detection of cancer |
Investigator(s): |
Lee KW, Yuen PW |
Department: |
Surgery |
Source(s) of Funding: |
Small Project Funding |
Start Date: |
09/2005 |
Completion Date: |
08/2006 |
Abstract: |
Nasopharyngeal carcinoma (NPC) occurs
sporadically in the west but is endemic in southern |
List of Research Outputs |
Researcher
: Lee MF |
List of Research Outputs |
Ching Y.P., Leong V.Y.L., Lee M.F., Xu H., Jin D. and Ng I.O.L., P21-activated protein kinase is overexpressed in hepatocellular carcinoma and enhances cancer metastasis involving c-Jun NH2-terminal kinase activation and paxillin phosphorylation. , Cancer Research. 2007, 67: 3601-3608. |
Ching
Y.P., Leong V.Y.L., Lee M.F. and Ng I.O.L., Pak1 overexpression is
important in the metastasis of hepatocellular carcinoma, Queenstown
Molecular Biology |
Wong C.M., Ng Y.L., Lee M.F., Wong C.L., Cheung O.F., Chan P.C.Y., Tung K.K., Ching Y.P. and Ng I.O.L., Tissue factor pathway inhibitor-2 as a frequently silenced tumor suppressor gene in hepatocellular carcinoma, Hepatology. 2007, 45(5): 1129-1138. |
Researcher
: Lee MY |
Project Title: |
Role of Cyclooxygenase-2 (COX-2) in Pro-inflammatory Response of Severe Acute Respiratory Syndrome (SARS) Coronavirus-Infected Human Primary Monocyte-derived Macrophages and the Potential Use of its Inhibitors for the Therapy of SARS |
Investigator(s): |
Lee MY, Peiris JSM, Cheung CY, Nicholls JM |
Department: |
Microbiology |
Source(s) of Funding: |
Small Project Funding |
Start Date: |
01/2007 |
Abstract: |
Severe acute respiratory syndrome (SARS)
emerged firstly in |
Project Title: |
Role of cyclooxygenase-2 (COX-2) influenza A (subtype H5N1) viral pathogenesis and the potential use of its inhibitors for the therapy of H5N1 disease |
Investigator(s): |
Lee MY, Peiris JSM, Cheung CY |
Department: |
Microbiology |
Source(s) of Funding: |
Research Fund for the Control of Infectious Diseases - Full Grants |
Start Date: |
01/2007 |
Abstract: |
To investigate the role of COX |
List of Research Outputs |
Researcher
: Lee TYH |
List of Research Outputs |
Chan
T.L., Yuen S.T., Lo M.W.S., Lee T.Y.H., Kong C.K., Chan Y.W., Tsui W.Y., Li V.S.W., Chan A.S.Y. and Leung S.Y., Study of the mechanisms
underlying heritable germline epimutation of MSH |
Researcher
: Leong VYL |
List of Research Outputs |
Ching
Y.P., Leong V.Y.L., Lee M.F. and Ng I.O.L., Pak1 overexpression is
important in the metastasis of hepatocellular carcinoma, Queenstown
Molecular Biology |
Researcher
: Leung CY |
List of Research Outputs |
Tang S.C.W., Chan K.W., Tang C.S.O., Lam M.F., Leung C.Y., Tse K.C., Li C.S., Ho Y.W., Tong K.L., Lai K.N., Chan D.T.M. and Hong Kong Nephrology Study Group ., Conversion of ciclosporin A to tacrolimus in kidney transplant recipients with chronic allograft nephropathy, Nephrology Dialysis Transplantation. 2006, 21(11): 3243-51. |
Researcher
: Leung LH |
List of Research Outputs |
Leung L.H., Chung L.P., Tam Y.S.I., Tin P.C. and Wong M.P., Src kinase pathway is a potential candidate for molecular targeted therapy of non-small cell lung cancers (NSCLC) that show exon 19 deletion mutation or other epidermal growth factor (EGFR) abnormalities., AACR annual meeting 2007, Los Angeles, CA. 2007, 301. |
Leung L.H., Chung L.P. and Wong M.P., Src kinase pathway is a potential candidate for molecular targeted therapy of non-small cell lung cancers (NSCLC) that show exon 19 deletion mutation or other epidermal growth factor receptor (EGFR) abnormalities , American Association for Cancer Research Annual Meeting, Los Angeles, California, the United State . 2007. |
Leung L.H., Chung L.P. and Wong M.P., Src kinase-a potential drug target in treating non-small cell lung cancer (NSCLC), 1st Annual John R. Murren Memorial Symposium: Advances in Thoracic Oncology, Yale Continuing Medical Education and Nevada Cancer Institute, Las Vegas, Nevada, USA . 2007. |
Tam
Y.S.I., Leung L.H., Chung L.P. and Wong M.P., EGFR with L858R and H870R
double mutations showed reduced sensitivity to Gefitinib., AACR annual
meeting 2007, |
Tam Y.S.I., Leung L.H., Chung L.P. and Wong M.P., Germline EGFR mutation is uncommon and plays a limited role in predisposition to lung cancer., AACR annual meeting 2007, Los Angeles, CA. 2007, 32. |
Researcher
: Leung SY |
Project Title: |
Identification of BRAF mutation in various stages of colorectal carcinogenesis and its relationship with KRAS mutation |
Investigator(s): |
Leung SY, |
Department: |
Pathology |
Source(s) of Funding: |
Small Project Funding |
Start Date: |
11/2002 |
Abstract: |
To examine the biological relationship of BRAF mutation with KRAS mutation. The association of mutations in these two genes with clinico-pathological features, molecular parameters and prognosis will be sought. |
Project Title: |
High resolution mapping of chromosomal aberrations by cDNA microarray-based comparative genomic hybridisation and their correlation with gene expression profile of gastric adenocarcinoma |
Investigator(s): |
Leung SY, |
Department: |
Pathology |
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
Start Date: |
11/2002 |
Abstract: |
The project attempts to achieve a high resolution mapping of the chromosomal gains and losses in primary gastric cancer samples by hybridisation of genomic DNA to a microarray containing 44,000 human cDNA clones. The changes of DNA copy number will then be correlated with gene expression profiles already available in the gastric cancer samples, generated using the same cDNA microarray. New oncogenes or tumour suppressor genes may be identified in these regions that may constitute new targets for diagnosis, prognostication and pathway specific therapeutic strategy. |
Project Title: |
Delineation of prognostic biomarkers in gastric cancer using cDNA microarray data, validation in independent dataset and their functional characterisation |
Investigator(s): |
Leung SY, |
Department: |
Pathology |
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
Start Date: |
11/2003 |
Abstract: |
To identify a list of genes that significantly predict tumour behaviour and patient outcome in a cohort of 90 gastric adenocarcinoma patients studied by cDNA microarray; to validate the prognostic significance of the top 50 survival genes in a large independent cohort of gastric adenocarcinoma patients using a combination of real-time quantitative RT-PCR, in-situ hybridisation and immunohistochemistry performed in high-density tissue microarray; to carry out functional characterisation of the survival genes using various cell culture and animal models. |
Project Title: |
Detail study of relationship of BRAF and KRAS mutation with microstatellite instability in colorectal cancer |
Investigator(s): |
Leung SY, |
Department: |
Pathology |
Source(s) of Funding: |
Small Project Funding |
Start Date: |
11/2003 |
Abstract: |
To examine in detail the incidence of BRAF and KRAS mutation in a large series of MSI colorectal cancer with detail characterization of germine MMR gene mutation and MLH1 promoter methylation. |
Project Title: |
Genomic screening for potential tumour suppressors silenced by promoter hypermethylation in gastric adenocarcinomas using cDNA microarray |
Investigator(s): |
Leung SY, |
Department: |
Pathology |
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
Start Date: |
01/2005 |
Abstract: |
Gastric cancer, being the second most
common cancer worldwide, continues to present with poor prognosis and obscure
cause. In view of the relatively high regional incidence in Hong Kong and
certain parts of |
Project Title: |
Systematic characterisation of genes participating in Wnt signaling pathway that regulate colon stem cell renewal and their functional significance in colon cancer pathogenesis |
Investigator(s): |
Leung SY, Chen X, |
Department: |
Pathology |
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
Start Date: |
12/2006 |
Abstract: |
To identify a set of putative Wnt target genes that are highly likely to contribute to colorectal carcinogenesis and stem cell phenotype using existing genomics databases; to validate their regulation by Wnt using quantitative RT-PCR on colon cancer cell lines with inducible blockage of Wnt signaling; to examine for variation in expression level of these validated Wnt targets in large numbers of CRCs, adenomas and normal colon mucosae using tissue microarray; to classify at a molecular level CRC using expression data of multiple validated Wnt target genes and to correlate expression levels of these validated Wnt targets with clinico-pathological parameters patient outcome and molecular genetic changes; to functionally characterize several validated Wnt targets with significant clinicopathological correlation using cell culture systems; to analyse promoters for putative Tcf binding sites in selected validated Wnt target and their confirmation using luciferase reporter assay. |
List of Research Outputs |
Cavenee W.K., Burger P.C., Leung S.Y. and van Meir E.G., Turcot Syndrome. The WHO Classification of Tumours of the Nervous System, 2007, 4th Edition. |
Chan A.O.O., Chu K.M., Huang C.Y., Lam K.F., Leung S.Y., Sun Y., Ko S., Xia H.H.X., Cho C.H., Hui W.M., Lam S.K. and Rashid A., Association between Helicobacter pylori infection and interleukin 1beta polymorphism predispose to CpG island methylation in gastric cancer, GUT. 2007, 56: 595-597. |
Chan K.H., Leung S.Y., Cheung R.T.F., Ho S.L. and Mak W., Paraneoplastic motor neuropathy and inflammatory myopathy associated with nasopharyngeal carcinoma, J Neurooncol. 2007, 81(1): 93-6. |
Chan
T.L., Yuen S.T., Kong C.K., Chan Y.W., Chan A.S.Y., Ng W.F., Tsui W.Y., Lo M.W.S., Tam W.Y., Li V.S.W. and Leung S.Y., Heritable germline
epimutation of MSH |
Chan
T.L., Yuen S.T., Kong C.K., Chan Y.W., Chan A.S.Y. and Leung S.Y., Heritable germline
epimutation of MSH |
Chan T.L., Guo D., Yuen S.T., Chan Y.W., Chan A.S.Y. and Leung S.Y., Immunohistochemical staining on tissue microarray of colorectal cancers constitutes a convenient means to rapidly screen for MMR deficiency, The Second Biennial Scientific Meeting of the International Society for Gastrointestinal Hereditary Tumours, InSiGHT, March 27-30, 2007, Yokohama, Japan. 2007. |
Chan
T.L., Yuen S.T., Lo M.W.S., Lee T.Y.H., Kong C.K., Chan Y.W., Tsui W.Y., Li V.S.W., Chan A.S.Y. and Leung S.Y., Study of the mechanisms
underlying heritable germline epimutation of MSH |
Edkins S., O'meara S., Parker A., Stevens C., Reis M., Jones S., Greenman C., Davies H., Dalgliesh G., Forbes S., Hunter C., Smith R., Stephens P., Goldstraw P., Nicholson A., Chan T.L., Velculescu V.E., Yuen S.T., Leung S.Y., Stratton M.R. and Futreal A., Recurrent KRAS Codon 146 Mutations in Human Colorectal Cancer, Cancer Biology & Therapy. 2006, 5(8): 928-932. |
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G., Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A. and Stratton M.R., Patterns of somatic mutation in human cancer genomes, Nature. 2007, 446 (7132): 153-8. |
Guo D., Yuen S.T., Tsui W.Y., Chan A.S.Y., Chan T.L. and Leung S.Y., Expression of wnt signaling target genes in colorectal cancer progression, Proceedings of the 98th Annual Meeting of the American Association for Cancer Research. 2007. |
Leung S.Y., Croucher Senior Medical Research Fellowship, The Croucher Foundation . 2007. |
Leung
S.Y., Gene expression profiling, genetics and
epigenetics of gastrointestinal tract cancer, Laboratory of Human
Carcinogenesis, Center for Cancer Research, National Cancer Institute,
National Institutes of Health. |
Leung
S.Y., Gene expression profiling, genetics and
epigenetics of gastrointestinal tract cancer, Rosetta Inpharmatics LLC, (A
wholly owned subsidiary of Merck and Co. Inc.) |
Leung S.Y., Genetic and epigenetic mechanisms for the causation of Hereditary Non-Polyposis Colorectal Cancer Syndrome, The Fifth Asia Pacific International Academy of Pathology Congress, Raffles City Convention Centre, Singapore. 2007. |
Leung S.Y., Molecular subtypes of colorectal cancer – implications for genetic susceptibility, prognosis and response to treatment, 3rd Organisation for Oncology and Translational Research (OOTR) Annual Conference: Neoadjuvant & Molecular Therapy in Cancer, 22-23 September, 2006. 2006. |
Leung S.Y., Chan T.L. and Yuen S.T., Reply to "Heritable germline epimutation is not the same as transgenerational epigenetic inheritance", Nat Genet. 2007, 39(5): 576. |
Li V.S.W., Yuen S.T., Chan A.S.Y., Tsui W.Y., Chen X. and Leung S.Y., Investigation of signaling pathways that regulate human colon crypt maturation and their dysregulation in tumorigenesis, Proceedings of the 98th Annual Meeting of the American Association for Cancer Research . 2007. |
Ng S.M., Cheung Y.T., An X.M., Chen Y.C., Li M., Li H.Y., Cheung K.C., Sze J., Lai L., Peng Y., Xia H.H.X., Wong B.C.Y., Leung S.Y., Xie D., He M.L., Kung H.F. and Lin M.C., Cell Cycle-related Kianse: A Novel Candidate Oncogene in Human Glioblastoma, Journal of the National Cancer Institute. 2007, 99(12): 936-948. |
Sheng J.Q., Chan T.L., Chan Y.W., Huang J.S., Chen J.G., Zhang M.Z., Guo X.L., Mu H., Chan A.S.Y., Li S.R., Yuen S.T. and Leung S.Y., Microsatellite instability and novel mismatch repair gene mutations in northern Chinese population with Hereditary non-polyposis colorectal cancer, Chin J Dig Dis . 2006, 7(4): 197-205. |
Zou B., Chim J.C.S., Zeng H., Leung S.Y., Yang Y., Tu S., Lin M.C., Wang J., He H., Jiang S.H., Sun Y., Yu L., Yuen S.T., Kung H.F. and Wong B.C.Y., Correlation Between the Single-site CpG Methylation and Expression Silencing of the XAF1 Gene in Human Gastric and Colon Cancers, Gastroenterology. 2006, 131(6): 1835-1843. |
Researcher
: Leung THY |
Project Title: |
Functional
characterization of DLC |
Investigator(s): |
Leung THY, Ng IOL |
Department: |
Pathology |
Source(s) of Funding: |
Small Project Funding |
Start Date: |
10/2006 |
Abstract: |
The purpose of this study is to
characterize the putative tumor suppressor gene, deleted in liver cancer 2,
DLC2, functionally in liver cancer (hepatocellular carcinoma, HCC), which is
a prevalent cancer in Southeast Asia including |
List of Research Outputs |
Leung
T.H.Y., Ching
Y.P., Yam J.W.P. and Ng I.O.L., DLC2 (deleted in liver cancer
2) suppresses cell growth via the regulation of p70S6K, Queenstown
Molecular Biology |
Yam J.W.P., Ko C.F., Chan C.Y., Yau T.O., Tung K.K., Leung T.H.Y., Jin D. and Ng I.O.L., Tensin2 variant 3 is associated with aggressive tumor behavior in human hepatocellular carcinoma, Hepatology. 2006, 44: 881-890. |
Yam J.W.P., Ko C.F., Chan P.C.Y., Yau T.O., Tung K.K., Leung T.H.Y., Jin D. and Ng I.O.L., Tensin2 variant 3 is associated with aggressive tumor behavior in human hepatocellular carcinoma, Queenstown Signal Transduction Meeting, New Zealand. 2006. |
Researcher
: Li VSW |
List of Research Outputs |
Chan
T.L., Yuen S.T., Kong C.K., Chan Y.W., Chan A.S.Y., Ng W.F., Tsui W.Y., Lo M.W.S., Tam W.Y., Li V.S.W. and Leung S.Y., Heritable germline
epimutation of MSH |
Chan
T.L., Yuen S.T., Lo M.W.S., Lee T.Y.H., Kong C.K., Chan Y.W., Tsui W.Y., Li V.S.W., Chan A.S.Y. and Leung S.Y., Study of the mechanisms
underlying heritable germline epimutation of MSH |
Li V.S.W., Yuen S.T., Chan A.S.Y., Tsui W.Y., Chen X. and Leung S.Y., Investigation of signaling pathways that regulate human colon crypt maturation and their dysregulation in tumorigenesis, Proceedings of the 98th Annual Meeting of the American Association for Cancer Research . 2007. |
Researcher
: Liang ACT |
List of Research Outputs |
Chen W.Y.W., Hu X., Liang A.C.T., Au W.Y., So J.C.C., Wong M.L.Y., Shen L., Tao Q., Chu K.M., Kwong Y.L. and Srivastava G., High BCL6 expression predicts better prognosis, independent of BCL6 translocation status, translocation partner, or BCL6 deregulating mutations, in gastric lymphoma, Blood. 2006, 108: 2373-2383. |
Researcher
: Liao X |
List of Research Outputs |
Au
C.W.H., Siu K.Y., Liao X., Ngan H.Y.S. and Cheung A.N.Y., Tropomyosin-related
kinase B and brain-derived neurotrophic factor in ovarian cancer.
[abstract]., In: American Association for Cancer Research Annual Meeting:
Proceedings; Apr 14-18; |
Liao X., Xue W.C., Shen D.H., Ngan H.Y.S., Siu K.Y. and Cheung A.N.Y., p63 expression in ovarian tumours: a marker for Brenner tumours but not transitional cell carcinomas., Histopathology. 2007, in press. |
Liu S., Chan Y.K., Cheung A.N.Y., Liao X., Leung T.W. and Ngan H.Y.S., Expression of {Delta}Np73 and TAp73{alpha} Independently Associated with Radiosensitivities and Prognoses in Cervical Squamous Cell Carcinoma, Clinical Cancer Research . 2006, 12: 3922-7. |
Researcher
: Liu MHF |
List of Research Outputs |
Liu
M.H.F., Leong
V.Y.L., Ng I.O.L. and Ching Y.P., The tumor suppressive
function of AMPK in hepatocellular carcinoma, Proceedings of the Annual
Meeting of American Association for Cancer Research, |
Researcher
: Liu W |
List of Research Outputs |
Chan Y.K., Tse Y.T., Chan S.Y., Liu W., Garcia-Barcelo M.M., Sham P.C. and Khoo U.S., Estrogen receptors genetic polymorphisms risk association and their functional roles in breast cancer risk: a study on Hong Kong Chinese women, 100th American Association for Cancer Research Annual Meeting, Los Angeles, CA, USA . 2007, Abstract no. 5269. |
Khoo
U.S., Liu W., Long
J.R., Yip S.P., Cheung A.N.Y., Chua D.T.T., Chan S.Y., Ngan H.Y.S., Zheng W. and Chan Y.K., The functional |
Researcher
: Lo CK |
List of Research Outputs |
Lam Q.L.K., Lo C.K., Zheng B., Ko K.H., Osmond D.G., Wu G.E., Rottapel R. and Lu L., Impaired V(D)J recombination and increased apoptosis among B cell precursors in the bone marrow of c-Abl-deficient mice., International Immunology. 2007, 19(3): 267-76. |
To
K.W., Wong O.H., Li H.B., Chen
S.F., Lo C.K., Chiang A.K.S. and Huang F., Effects Of Bergapten On
Dendritic Cell Functions, The 9th International Syposium on Dendritic
Cells, |
To K.W., Wong O.H., Li H.B., Chen S.F., Lo C.K., Chiang A.K.S. and Huang F., Immunomodulatory effects of
Bergapten on dendritic cell functions, 9th
International Conference on Dendritic Cell, |
Researcher
: Lo KC |
List of Research Outputs |
Ko K.H., Lam Q.L.K., Zhang M., Wong C.K.Y., Lo K.C., Kahmeyer-Gabbe M., Tsang W.H., Tsang S.L., Chan L.C., Sham M.H. and Lu L., Hoxb3 deficiency impairs B lymphopoiesis in mouse bone marrow, Experimental Hematology. 2007, 35(3): 465-75. |
Researcher
: Lo MWS |
List of Research Outputs |
Chan
T.L., Yuen S.T., Kong C.K., Chan Y.W., Chan A.S.Y., Ng W.F., Tsui W.Y., Lo M.W.S., Tam W.Y., Li V.S.W. and Leung S.Y., Heritable germline
epimutation of MSH |
Chan
T.L., Yuen S.T., Lo M.W.S., Lee T.Y.H., Kong C.K., Chan Y.W., Tsui W.Y., Li V.S.W., Chan A.S.Y. and Leung S.Y., Study of the mechanisms
underlying heritable germline epimutation of MSH |
Researcher
: Lu L |
Project Title: |
B cell apoptosis and its regulation in autoimmunity |
Investigator(s): |
Lu L |
Department: |
Pathology |
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
Start Date: |
09/2003 |
Abstract: |
To study the regulation of B cell development and survival by BLyS and APRIL in mouse bone marrow; to examine B cell apoptosis and its regulation in the development of CIA as a model of RA; to determine if BLyS and/or APRIL participate(s) in the pathogenesis of CIA. |
Project Title: |
Natural killer cells and the pathogenesis of autoimmunity |
Investigator(s): |
Lu L |
Department: |
Pathology |
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
Start Date: |
10/2004 |
Abstract: |
To study : (1) NK cell development during the pathogenesis of autoimmune arthritis. (2) NK cell interaction with T and B cells under autoimmune conditions. (3) role of NK cells in the development of autoimmune arthritis. |
Project Title: |
Functional interactions of dendritic cells and B cells in autoimmunity |
Investigator(s): |
Lu L |
Department: |
Pathology |
Source(s) of Funding: |
NSFC/RGC Joint Research Scheme |
Start Date: |
03/2005 |
Abstract: |
To study: (1) roles of BLyS in regulating DCs and B cell functions in autoimmunity, (2) roles of heat-shock proteins in regulating functions of DCs and B cells, (3) roles of HSPs in regulating autoimmune arthritis development. |
Project Title: |
Role of leptin receptor signaling in the maturation and function of dendritic cells |
Investigator(s): |
Lu L |
Department: |
Pathology |
Source(s) of Funding: |
Small Project Funding |
Start Date: |
08/2006 |
Abstract: |
Leptin, originally discovered as a
hormone produced primarily in adipose cells, plays a critical role in
regulating nutrient intake and metabolism. There is increasing evidence that
leptin acts as a growth factor by stimulating proliferation and inhibiting
apoptosis in human and murine T lymphocytes (1-3). Several studies have
revealed an important role for leptin in regulating lymphopoiesis and
hematopoeisis. For example, leptin has been shown to increase the production
of a variety of cytokines in rodent T cells and monocytes/macrophages
(1,4-6). Moreover, leptin is involved in modulating immune responses towards
the Th1 phenotype and suppressing the Th2 effect by stimulating CD4+ T
lymphocyte proliferation (1,7). In relation to the important function of
leptin in immune response, the leptin receptor expression has been found not
only in the central nervous system but also in the peripheral lymphoid
tissues and hematopoietic stem cells (1,8-10). Encoded by the diabete (db)
gene, the leptin receptor (Ob-R) is a member of class I cytokine receptors,
which has signaling capability of IL-6 type cytokine receptors. Ob-R mRNA
gives rise to six different forms of the receptor by alternative splicing but
only the long isoform (Ob-Rb) has been recognized to be of prime importance
in leptin-mediated signaling. Early studies on db/db mice, in which the
leptin receptor Ob-Rb that transduces signals through leptin binding is
truncated, have revealed that B and T cell development and maturation are
severely affected with reduced numbers of lymphocytes in the peripheral
lymphoid organs (8). Dendritic cells (DCs) play a pivotal role as
professional APCs due to its high potency and versatility in immune function.
We have recently identified the microenvironmental factors that can affect DC
function (11,12). Moreover, our pilot studies have demonstrated that DCs
express surface leptin receptor as analyzed by quantitative PCR and
immunofluorescence microscopy. Although the role of leptin in regulating
immune functions of lymphocytes and macrophage has been widely studied,
whether and to what extent leptin signaling modulates DC function remain
largely unclear. To better understand the physiological function of leptin
signaling in DC development, this project will focus on studying DC maturation
and function in leptin-receptor deficient db/db mice. Objectives of this
proposal:1. To examine the phenotype and costimulatory molecule expression on
DCs derived from db/db BM cultures. 2. To evaluate the capacity of db/db DCs
in stimulating allogeneic T cell proliferation.3. To determine the profile of
cytokine production by db/db DCs.4. To elucidate the signaling transduction
pathways underlying the maturation and function of db/db DCs.References1.
Lord, G. M., Matarese, G., Howard, J. K., Baker, R. J., Bloom, S. R., and
Lechler, R. I. 1998. Leptin modulates the T-cell immune response and reverses
starvation-induced immunosuppression. Nature 394:897-901.2. Howard, J. K.,
Lord, G. M., Matarese, G., Vendetti, S., Ghatei, M. A., Ritter, M. A.,
Lechler, R. I., and Bloom, S. R. 1999. Leptin protects mice from
starvation-induced lymphoid atrophy and increases thymic cellularity in ob/ob
mice. J Clin Invest 104:1051-9.3. Fujita, Y., Murakami, M., Ogawa, Y.,
Masuzaki, H., Tanaka, M., Ozaki, S., Nakao, K., and Mimori, T. 2002. Leptin
inhibits stress-induced apoptosis of T lymphocytes. Clin Exp Immunol
128:21-6.4. Faggioni, R., Feingold, K. R., and Grunfeld, C. 2001. Leptin
regulation of the immune response and the immunodeficiency of malnutrition.
Faseb J 15:2565-71.5. Loffreda, S., Yang, S. Q., Lin, H. Z., Karp, C. L.,
Brengman, M. L., Wang, D. J., Klein, A. S., Bulkley, G. B., Bao, C., and
Diehl, A. M. 1998. Leptin regulates proinflammatory immune responses. Faseb J
12:57-65.6. Santos-Alvarez, J., Goberna, R., and Sanchez-Margalet, V. 1999.
Human leptin stimulates proliferation and activation of human circulating
monocytes. Cell Immunol 194:6-11.7. Shigemura, N., Ohta, R., Kusakabe, Y.,
Miura, H., Hino, A., Koyano, K., Nakashima, K., and Ninomiya, Y. 2004. Leptin
modulates behavioral responses to sweet substances by influencing peripheral
taste structures. Endocrinology 145:839-47.8. Bennett, B. D., Solar, G. P.,
Yuan, J. Q., Mathias, J., Thomas, G. R., and Matthews, W. 1996. A role for
leptin and its cognate receptor in hematopoiesis. Curr Biol 6:1170-80.9.
Nakata, M., Yada, T., Soejima, N., and Maruyama, |
Project Title: |
Innovative development of a gene-targeted therapy for rheumatoid arthritis |
Investigator(s): |
Lu L, Ko KH |
Department: |
Pathology |
Source(s) of Funding: |
Innovation and Technology Support Programme |
Start Date: |
09/2006 |
Abstract: |
1. To characterize the immune mechanisms underlying the pathogenic role of BAFF in the development of autoimmune arthritis. 2. To construct a recombinant lentiviral expression system to deliver small hairpin RNAs for BAFF-gene silencing. 3. To evaluate the efficacy and safety of in vivo application of the recombinant lentiviral vector expressing short-hairpin RNA for BAFF gene-silencing in the treatment of autoimmune arthritis. |
Project Title: |
Plasma cell development and its regulation in autoimmunity |
Investigator(s): |
Lu L |
Department: |
Pathology |
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
Start Date: |
01/2007 |
Abstract: |
To study PC generation and functional characteristics upon immunization; to examine the regulatory mechanisms underlying PC migration and survival; to characterize the development of PCs during the progression of autoimmune arthritis; to study the molecular mechanism involved in regulating PC development in autoimmune arthritis. |
List of Research Outputs |
Ko K.H., Lam Q.L.K., Zhang M., Wong C.K.Y., Lo K.C., Kahmeyer-Gabbe M., Tsang W.H., Tsang S.L., Chan L.C., Sham M.H. and Lu L., Hoxb3 deficiency impairs B lymphopoiesis in mouse bone marrow, Experimental Hematology. 2007, 35(3): 465-75. |
Lam Q.L.K., Lo C.K., Zheng B., Ko K.H., Osmond D.G., Wu G.E., Rottapel R. and Lu L., Impaired V(D)J recombination and increased apoptosis among B cell precursors in the bone marrow of c-Abl-deficient mice., International Immunology. 2007, 19(3): 267-76. |
Lam Q.L.K., Liu S., Cao X. and Lu L., Involvement of leptin signaling in the survival and maturation of bone marrow-derived dendritic cells, European Journal of Immunology. 2006, 36(12): 3118-30. |
Lam Q.L.K. and Lu L., Role of leptin in immunity, Cell Mol Immunol. 2007, 4(1): 1-13. |
Liu Q., Chen T., Chen G., Shu X., Sun A., Ma P., Lu L. and Cao X., Triptolide impairs dendritic cell migration by inhibiting CCR7 and COX-2 expression through PI3-K/Akt and NF-kappaB pathways, Molecular Immunology. 2007, 44(10): 2686-96. |
Lu
L., Immunosurveillance in Cancers:
Immunoselection and Immunosubversion, The 13th |
Lu
L., Regulation of B cell and dendritic cell
development in mouse bone marrow , The 7th Symposium of Molecular and
cellular immunity, November 18-22, |
Lu
L., Regulation of B cell and dendritic cell
development in mouse bone marrow, Hong Kong Society of Flow Cytometry,
March 24, 2007, |
Lu L., Role of Hoxb3 gene in regulating B lymphocyte development, Keynote address and Co-Chair, Symposium of Cellular Immunity, The 5th Immunology Congress, Chinese Society for Immunology, Jiangsu, China . 2006. |
Sun L.Y., Zhou K.X., Feng X.B., Zhang H.Y., Ding X.Q., Jin O., Lu L., Lau W.C.S., Hou Y.Y. and Fan L.M., Abnormal surface markers expression on bone marrow CD34+cells and correlation with disease activity in patients with systemic lupus erythematosus, Clin Rheumatol. 2007, [Epub ahead of print]. |
Yang M.X., Qu X., Kong B.H., Lam Q.L.K., Shao Q.Q., Deng B.P., Ko K.H. and Lu L., Membrane type 1-matrix metalloproteinase is involved in the migration of human monocyte-derived dendritic cells, Immunology and Cell Biology. 2006, 84(6): 557-62. |
Zheng B., Zhou J., Wu H.W., Poon K.M., Ng F., Chan C.S., Lu L. and Wen Y.M., IFNAR1 promoter polymorphisms associated with susceptibility to chronic HBV infection and functional implication., The 2006 International Meeting: The Molecular Biology of Hepatitis B Viruses. Vancouver, Canada., 2006. |
Zhou J., Lu L., Zhang B., Wong S., Chen Y., Poon K.M., Jiang S. and Zheng B., Genetic variations of type I interferon receptor 1 promoter and their association with chronic hepatitis B virus infection., Journal of Microbes and Infection. 2007, 2(1): 19-25. |
Zhou J., Wu H.W., Poon K.M., Ng F., Chan C.S., Qu D., Wen Y.M., Lu L. and Zheng B., Interferon receptor 1 promoter polymorphisms and susceptibility to chronic hepatitis B virus infection., 12th International Symposium on Viral Hepatitis and Liver Diseases. Paris, France., 2006. |
Zhou J., Lu L., Poon K.M., Wu H.W., Ng F., Chan C.S., Wen Y.M. and Zheng B., Polymorphisms in the type I interferon receptor I promoter affect its transcriptional activity and susceptibility to chronic HBV infection., The 2006 International Meeting: The Molecular Biology of Hepatitis B Viruses. . Vancouver, Canada., 2006. |
Zhou J., Lu L., Yuen R.M.F., Lam T.W., Chung C.P., Lam C.L., Zhang B., Wang S., Chen Y., Wu H.W., Poon K.M., Ng F., Chan C.S., Jiang S., Yuen K.Y. and Zheng B., Polymorphisms of type I interferon receptor 1 promoter and their effects on chronic hepatitis B virus infection, Journal of Hepatology. 2007, 46(2): 198-205. |
Researcher
: Ma ESK |
List of Research Outputs |
Au W.Y., Tsang S.K., Cheung B.K., Siu T.S., Ma E.S.K. and Tam S., Cough mixture abuse as a novel cause of folate deficiency: a prospective, community-based, controlled study, Haematologica. 2007, 92(4): 562-563. |
Au W.Y., Lam V.M.S., Pang A.W.K., Lee W.M., Chan L.C., Song Y., Ma E.S.K. and Kwong Y.L., Glucose-6-phosphate dehydrogenase deficiency in female octogenarians, nanogenarians, and centenarians, The Journals of Gerontology Series A: Biological Sciences and Medical Sciences . 2006, 61(10): 1086-1089. |
Au W.Y., Fung T.K., Ma E.S.K., Shek T.W.H., Hawkins B.R. and Liang R.H.S., HLA associations, microsatellite instability and epigenetic changes in thyroid lymphoma in Chinese, Leuk Lymphoma. 2007, 48(3): 531-534. |
Au W.Y., Fung A., Liu C.L., Fan S.T., Ma E.S.K., Liang R.H.S. and Kwong Y.L., Serial analysis of JAK2 mutation in a patient who developed essential thrombocythemia after orthotopic liver transplantation (Case Report), American Journal of Hematology. 2006, 81(11): 880-882. |
Au W.Y., Au W.Y., Fung T.K., Liu C.L., Fung T.K., Fung T.K., Fan S.T., Ma E.S.K., Liang R.H.S. and Kwong Y.L., Serial analysis of JAK2 mutation in a patient who developed essential thrombocythemia after orthotopic liver transplantation, American Journal of Hematology. 2006, 81(1): 880-882. |
Au W.Y., Ma E.S.K., Lee T.L., Ha S.Y., Fung T.K., Lie A.K.W. and Kwong Y.L., Successful treatment of thrombotic microangiopathy after haematopoietic stem cell transplantation with rituximab, British Journal of Haematology. Blackwell Publishing Ltd, 2007, 137: 475-478. |
Chan Y.Y., So J.C.C., Ma E.S.K. and Chan L.C., A laboratory strategy for genotyping hemoglobin H disease in the Chinese, J Clin Pathol. 2006, 60(8): 931-4. |
Chen M., Lam Y.H., Ma E.S.K., Wong K.Y. and Tang M.H.Y., Intrauterine therapy in a fetus with severe congenital dyserythropoietic anaemia, The Third International Scientific Meeting of the International Society of Ultrasound in Obstetrics and Gynecology, Hong Kong Convention and Exhibition Centre, Hong Kong, February 25-28, 2007. |
So
J.C.C., Chan A.Y.Y., Tsang S.T.Y.,
Lee A.C.W., Au W.Y., Ma E.S.K.
and Chan L.C., A novel beta-delta
globin gene fusion leads to over-expression of delta globin chain and a mild
thalassemia intermedia phenotype when co-inherited with beta-zero
thalassemia, 48th American Society of Hematology Annual Meeting and
Expositions. 2006, Blood Vol 108 No. 11 Part 1: |
So J.C.C., Chan Y.Y., Tsang S.T.Y., Lee C.W., Au W.Y., Ma E.S.K. and Chan L.C., A novel beta-delta globin gene fusion, anti-Lepore Hong Kong, leads to overexpression of delta globin chain and a mild thalassaemia intermedia phenotype when co-inherited with b0-thalassaemia, British Journal of Haematology. 2006, 136(1): 158-162. |
So J.C.C., Wan T.S.K., Yip S.F., Ma E.S.K., Lam C.C.K. and Chan L.C., Can morphological assessment limit the use of specific genetic testing to exclude chronic myeloid leukaemia?, Br J Haematol. 2007, 137(4): 377. |
Wan T.S.K., So J.C.C., Hui K.C., Yip S.F., Ma E.S.K. and Chan L.C., Diagnostic utility of dual fusion PML/RARalpha translocation DNA probe (D-FISH) in acute promyelocytic leukemia, Oncol Rep. 2007, 17(4): 799-805. |
Researcher
: Ma SKY |
List of Research Outputs |
Ma S.K.Y., Chan K.W., Ng I.O.L., Zheng B. and Guan X.Y., Identification and characterization of CD133+ hepatocellular carcinoma cells as cancer stem/progenitor cells, The 5th International Society for Stem Cell Research, June 2007, Cairns, Australia. 2007. |
Ma S.K.Y., Chan K.W. and Guan X.Y., Identification and characterization of tumorigenic liver cancer stem cells, Oral Presentation in the Young Investigator Award Session, The 13th Hong Kong International Cancer Congress, November 2006, Hong Kong. 2006. |
Ma S.K.Y., Chan K.W., Hu L., Lee K.W., Ng I.O.L., Wo Y.H., Zheng B. and Guan X.Y., Identification and characterization of tumorigenic liver cancer stem cells, Proceedings of the Annual Meeting of American Association for Cancer Research, Los Angeles, USA, April. 2007. |
Ma S.K.Y., Chan K.W. and Guan X.Y., Identification and characterization of tumorigenic liver cancer stem cells, The 11th Research Postgraduate Symposium, The University of Hong Kong, December 2006, Hong Kong. 2006. |
Ma S.K.Y., Chan K.W., Hu L., Lee K.W., Wo Y.H., Ng I.O.L., Zheng B. and Guan X.Y., Identification and characterization of tumorigenic liver cancer stem/progenitor cells, Gastroenterology. 2007, 132(7): 2542-2556. |
Ma S.K.Y., Guan X.Y., Beh S.L., Wong K.Y., Chan Y.P., Yuen H.F., Vielkind J. and Chan K.W., The significance of LMO2 expression in the progression of prostate cancer, The Journal of Pathology. 2006, 211(3): 278-85. |
Researcher
: Ma SKY |
List of Research Outputs |
Ma S.K.Y., Chan K.W., Ng I.O.L., Zheng B. and Guan X.Y., Identification and characterization of CD133+ hepatocellular carcinoma cells as cancer stem/progenitor cells, The 5th International Society for Stem Cell Research, June 2007, Cairns, Australia. 2007. |
Ma S.K.Y., Chan K.W. and Guan X.Y., Identification and characterization of tumorigenic liver cancer stem cells, Oral Presentation in the Young Investigator Award Session, The 13th Hong Kong International Cancer Congress, November 2006, Hong Kong. 2006. |
Ma S.K.Y., Chan K.W., Hu L., Lee K.W., Ng I.O.L., Wo Y.H., Zheng B. and Guan X.Y., Identification and characterization of tumorigenic liver cancer stem cells, Proceedings of the Annual Meeting of American Association for Cancer Research, Los Angeles, USA, April. 2007. |
Ma S.K.Y., Chan K.W. and Guan X.Y., Identification and characterization of tumorigenic liver cancer stem cells, The 11th Research Postgraduate Symposium, The University of Hong Kong, December 2006, Hong Kong. 2006. |
Ma S.K.Y., Chan K.W., Hu L., Lee K.W., Wo Y.H., Ng I.O.L., Zheng B. and Guan X.Y., Identification and characterization of tumorigenic liver cancer stem/progenitor cells, Gastroenterology. 2007, 132(7): 2542-2556. |
Ma S.K.Y., Guan X.Y., Beh S.L., Wong K.Y., Chan Y.P., Yuen H.F., Vielkind J. and Chan K.W., The significance of LMO2 expression in the progression of prostate cancer, The Journal of Pathology. 2006, 211(3): 278-85. |
Researcher
: Nanji AA |
List of Research Outputs |
Tipoe G.L., Leung T.M., Liong E.C., So H.S.H., Leung K.M., Lau T.Y., Tom W.M., Fung M.L., Fan S.T. and Nanji A.A., Inhibitors of inducible nitric oxide (NO) synthase are more effective than an NO donor in reducing carbon-tetrachloride induced acute liver injury, Histology and Histopathology. 2006, 21(11): 1157-1165. |
Researcher
: Ng IOL |
Project Title: |
Deciphering dysregulation of mitotic checkpoint control in liver cancer |
Investigator(s): |
Ng IOL, Jin D |
Department: |
Pathology |
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
Start Date: |
09/2003 |
Completion Date: |
02/2007 |
Abstract: |
1) To document and characterize dysregulation of mitotic checkpoint in hepatocellular carcinoma (HCC) by evaluating; a) mitotic checkpoint competence in HCC cell lines, b) expression and alterations of mitotic checkpoint genes and proteins in HCC cells and tissues, c) epigenetic causes of mitotic checkpoint defects in HCC; 2) to investigate the roles of hepatitis B virus-encoded X protein (HBx) in mitotic checkpoint in HCC; 3) to assess the clinical, pathological and prognostic significance of mitotic checkpoint dysfunction in HCC. |
Project Title: |
Characterization of T-cadherin in hepatocellular carcinoma |
Investigator(s): |
Ng IOL, Chan DW |
Department: |
Pathology |
Source(s) of Funding: |
Small Project Funding |
Start Date: |
11/2003 |
Abstract: |
To evaluate the expression of T-cadherin at mRNA and protein levels in human HCCs and in HCC cell lines; to investigate the factors which induce expression of T-cadherin in HCC. |
Project Title: |
Characterization of the dishevelled gene in Wnt/[beta]-catenin signaling in liver cancer |
Investigator(s): |
Ng IOL, Yam JWP, Chan DW |
Department: |
Pathology |
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
Start Date: |
01/2005 |
Abstract: |
The main objectives of this project are
to: 1) characterize the expression of Dvl, HDPR1, and Pk |
Project Title: |
Characterization of DLC1 gene, a novel tumour suppressor gene frequently deleted in liver cancer |
Investigator(s): |
Ng IOL, Jin D, Yam JWP, Ching YP |
Department: |
Pathology |
Source(s) of Funding: |
Michael Kadoorie Cancer Genetics Research Fund |
Start Date: |
01/2005 |
Abstract: |
To search for binding partners of DLC1;
to delineate the interaction between DLC1 and the downstream effector, ROCK,
in HCC cell lines and human HCCs; to assess the clinicopathologic
significance of ROCK and its relationship with DLC |
Project Title: |
Genome-wide methylation screening in search for novel tumour suppressor genes in liver cancer |
Investigator(s): |
Ng IOL, Ching YP, Wong CM |
Department: |
Pathology |
Source(s) of Funding: |
Michael Kadoorie Cancer Genetics Research Fund |
Start Date: |
01/2005 |
Abstract: |
To characterize HCC-specific hypermethylation profile in HCC cells using microarray approach; to identify novel tumour suppressor genes in HCC cells; to delineate epigenetic and genetic alterations of selected putative tumour suppressor genes in human HCC; to characterize tumour suppressor activities of selected novel tumour suppressor genes. |
Project Title: |
Functional characterization of DLC1 gene, a novel tumour suppressor gene frequently deleted in liver cancer |
Investigator(s): |
Ng IOL, Yau TO, Sham MH, Jin D, Ching YP |
Department: |
Pathology |
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
Start Date: |
01/2005 |
Abstract: |
To develop and characterize DLC-null mice using gene targeting technology; to delineate the interaction between DLC1 and the downstream effector, ROCK in HCC cell lines and human HCCs. |
Project Title: |
A study of molecular mechanisms and characterizing novel genes in liver cancer |
Investigator(s): |
Ng IOL |
Department: |
Pathology |
Source(s) of Funding: |
Senior Medical Research Fellowships |
Start Date: |
09/2005 |
Abstract: |
To investigate the genetic basis of genome instability in liver cancer in relation to competence of mitotic checkpoints, and hepatitis B virus. Different approaches will be used to study the functional aspects as well as clinicopathological and prognostic significance of these genetic changes, in order to shed light for new treatment modalities. |
Project Title: |
LRP6 coreceptor upregulation in liver cancer |
Investigator(s): |
Ng IOL |
Department: |
Pathology |
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
Start Date: |
04/2006 |
Abstract: |
The purpose of this study is to
characterize LRP6 (low-density lipoprotein receptor related protein)
genetically and functionally in liver cancer, which is a major cancer in
Southeast Asia and |
Project Title: |
Characterization of the roles of hepatitis B virus X protein in liver cancer |
Investigator(s): |
Ng IOL, Chan DW |
Department: |
Pathology |
Source(s) of Funding: |
Research Fund for the Control of Infectious Diseases - Full Grants |
Start Date: |
09/2006 |
Abstract: |
To investigate the alterations of HBx cell targets in HCC cells with knockdown of HBx by RNA interference (RNAi); to delineate the role of HBx in deregulation of mitotic checkpoint control; to characterize the cellular effects of natural HBx mutants in HCC cells. |
Project Title: |
Significance of LRP6 coreceptor upregulation in the aberrant activation of Wnt signaling in liver cancer |
Investigator(s): |
Ng IOL, Yam JWP, Ching YP, Yau TO |
Department: |
Pathology |
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
Start Date: |
01/2007 |
Abstract: |
To evaluate the expression profile,
genetic alterations, and clinical significance of LRP |
Project Title: |
Characterization of regulatory molecules of Wnt/beta-catenin signaling in liver cancer |
Investigator(s): |
Ng IOL |
Department: |
Pathology |
Source(s) of Funding: |
NSFC/RGC Joint Research Scheme |
Start Date: |
01/2007 |
Abstract: |
To analyze the expression patterns and activities of Dishevelled (Dv1) and DICKKOPf-1 (DKK1) in the Wnt/beta;-catenin signaling pathway in HCC tissues and cells; to functionally characterize these proteins of Wnt/β-catenin signaling pathway in HCC cells; to evaluate the clinicopathological and prognostic significance of these genes in human HCC. |
Project Title: |
Functional
characterization of the mitotic checkpoint protein MAD |
Investigator(s): |
Ng IOL |
Department: |
Pathology |
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
Start Date: |
03/2007 |
Abstract: |
Liver cancer (hepatocellular carcinoma, HCC) is a major malignancy worldwide and particularly prevalent in this region. In HCC, recurrent chromosomal abnormalities are common and these frequent gains and losses of chromosomes suggest that chromosomal instability significantly contributes to liver cancer formation. One major mechanism for chromosomal instability is through loss of mitotic checkpoint, which ensures orderly and faithful progression of cell division. MAD1 is a key protein in mitotic checkpoint control first identified by us, but its role in HCC is unclear. Recently, we have identified a novel, alternatively splicing isoform of MAD1 (MAD1-beta). Unlike MAD1, which localizes in nucleus, MAD1-beta localizes in cytoplasm. Our preliminary data suggest that MAD1-beta may bring MAD2 out of the nucleus, thus inhibiting mitotic checkpoint and promoting carcinogenesis. We hypothesize that MAD1 is dysregulated in HCC and both MAD1 and MAD1-beta bear pathogenetic and clinicopathological significance. We aim to systemically compare the characteristics of MAD1 and MAD1-beta and evaluate the expression and clinicopathological significance of MAD1/MAD1beta and their correlation with HBx in HCC. Our work will significantly advance our understanding of HCC development and may provide insight for establishment of new effective therapy targeting the mitotic checkpoint. |
Project Title: |
Molecular pathology of liver cancer - a multidisciplinary study |
Investigator(s): |
Ng IOL, Cheung ST, Poon RTP, Ching YP, Guan XY, Jin D, Fan ST, Huang J, Lai CL |
Department: |
Pathology |
Source(s) of Funding: |
Central Allocation Vote - Group Research Project |
Start Date: |
04/2007 |
Abstract: |
1) To elucidate the genetic and molecular alterations in multistep hepatocarcinogenesis – We will use a comprehensive approach to perform genome-wide analysis with HCC tissues and cells as well as animal models. We will determine microRNA expression profile and also characterize the role of hepatitis B virus (HBV) in different disease stages of HCC. 2) To characterize Rho/ROCK/PTEN/AKT signaling pathway in this multistep hepatocarcinogenesis - We will define the critical events in this major oncogenic pathway that have significant impact on HCC development and progression. Particularly, we will delineate the role of this pathway in angiogenesis. |
List of Research Outputs |
Chan A.C.Y., Lo C.M., Ng I.O.L. and Fan S.T., Liver transplantation for combined hepatocellular cholangiocarcinoma, Asian Journal of Surgery. 2007, 30(2): 143-146. |
Chan D.W. and Ng I.O.L., Identification of CPGL-B as a candidate suppressor in cell growth and metastasis in human hepatocellular carcinoma, Clinical Cancer Research. 2006, 12: 6617-6625. |
Chan D.W., Chan P.C.Y., Yam J.W.P., Ching Y.P. and Ng I.O.L., Prickle-1 negatively regulates wnt/beta-catenin pathway by promoting dishevelled ubiquitination/degradation in liver cancer, Gastroenterology. USA, Elsevier Inc, 2006, 131: 1218-1227. |
Chan
K.C., Yau T.O., Ng I.O.L. and Chung S.K., Deleted in liver cancer 2
(DLC2) knockout mice show fast response to heat induced-pain, 11th
Postgraduate symposium 2006, |
Cheung S.T., Fan S.T., Lee Y.T., Ng I.O.L. and Lo C.M., Biomarker in relation to post-transplant recurrence in liver cancer patients (Abstract), The 2nd Nanjing-Hong Kong Liver Transplantation Symposium, Nanjing, China, 25 - 27 August 2006. |
Ching Y.P., Leong V.Y.L., Lee M.F., Xu H., Jin D. and Ng I.O.L., P21-activated protein kinase is overexpressed in hepatocellular carcinoma and enhances cancer metastasis involving c-Jun NH2-terminal kinase activation and paxillin phosphorylation. , Cancer Research. 2007, 67: 3601-3608. |
Ching
Y.P., Leong V.Y.L., Lee M.F. and Ng I.O.L., Pak1 overexpression is
important in the metastasis of hepatocellular carcinoma, Queenstown
Molecular Biology |
Ho J.C.Y., Cheung S.T., Poon W.S., Lee Y.T., Ng I.O.L. and Fan S.T., Down-regulation of retinol binding protein 5 is associated with aggressive tumor features in hepatocellular carcinoma, Journal of Cancer Research and Clinical Oncology. 2007. |
Hui
C.F., Yau T.O., Ching Y.P. and Ng I.O.L., Rapamycin and CCI-779
suppress the growth of hepatocellular carcinoma cells, Proceedings of the
Annual Meeting of American Association for Cancer Research, |
Lee K.W., Man K., Poon R.T.P., Lo C.M., Yuen P.W., Ng I.O.L., Ng T.P., Leonard W. and Fan S.T., Signal transducers and activators of transcription 5b activation enhances hepatocellular carcinoma aggressiveness through induction of epithelial-mesenchymal transition, Cancer Research. 2006, 66(20): 9948-9956. |
Leung
T.H.Y., Ching Y.P., Yam J.W.P. and Ng I.O.L., DLC2 (deleted in liver
cancer 2) suppresses cell growth via the regulation of p70S6K, Queenstown
Molecular Biology |
Li H., Fung K.L., Jin D., Chung S.S.M., Ching Y.P., Ng I.O.L., Sze K.H., Ko C.B. and Sun H., Solution Structures, Dynamics, and Lipid-binding of the Sterile a-Motif Domain of the Deleted in Liver Cancer 2, PROTEINS: Structure, Function, and Bioinformatics. 2007, 67: 1154-1166. |
Liu C.L., Fan S.T., Cheung S.T., Lo C.M., Ng I.O.L. and Wong J., Anterior approach versus conventional approach right hepatic resection for large hepatocellular carcinoma: a prospective randomized controlled study, Annals of Surgery. 2006, 244(2): 194-203. |
Liu
M.H.F., Leong V.Y.L., Ng I.O.L. and Ching Y.P., The tumor suppressive
function of AMPK in hepatocellular carcinoma, Proceedings of the Annual
Meeting of American Association for Cancer Research, |
Lo C.M., Liu C.L., Chan S.C., Lam C.M., Poon R.T.P., Ng I.O.L., Fan S.T. and Wong J., A randomized, controlled trial of postoperative adjuvant interferon therapy after resection of hepatocellular carcinoma, Annals of Surgery. 2007, 245(6): 831-842. |
Lo C.M., Fan S.T., Liu C.L., Chan S.C., Ng I.O.L. and Wong J., Living donor versus deceased donor liver transplantation for early unresectable hepatocellular carcinoma, British Journal of Surgery. 2007, 94(1): 78-86. |
Ma S.K.Y., Chan K.W., Ng I.O.L., Zheng B. and Guan X.Y., Identification and characterization of CD133+ hepatocellular carcinoma cells as cancer stem/progenitor cells, The 5th International Society for Stem Cell Research, June 2007, Cairns, Australia. 2007. |
Ma S.K.Y., Chan K.W., Hu L., Lee K.W., Ng I.O.L., Wo Y.H., Zheng B. and Guan X.Y., Identification and characterization of tumorigenic liver cancer stem cells, Proceedings of the Annual Meeting of American Association for Cancer Research, Los Angeles, USA, April. 2007. |
Ma S.K.Y., Chan K.W., Hu L., Lee K.W., Wo Y.H., Ng I.O.L., Zheng B. and Guan X.Y., Identification and characterization of tumorigenic liver cancer stem/progenitor cells, Gastroenterology. 2007, 132(7): 2542-2556. |
Ng I.O.L., Asian Journal of Oral and Maxillofacial Surgery. 2006. |
Ng I.O.L., Asian Journal of Surgery. 2006. |
Ng
I.O.L., Epigenetic gene expression profiling
to identify frequently silenced candidate tumor suppressor genes in cancers, 5th
|
Ng I.O.L., Journal of Clinical Oncology (Chinese version). 2006. |
Ng I.O.L., Journal of Gastroenterology and Hepatology. 2006. |
Ng I.O.L., Molecular pathology and genetic alterations in hepatocellular carcinoma, Laboratory of Experimental Carcinogenesis, Center for Cancer Research, National Institute of Health, Bethesda, USA, April. 2007. |
Ng I.O.L., The role of pathology and pathologists in the detection and management of cancer, Hong Kong Medical Journal. 2007, 13(1): 5-7. |
Tong A.C.K., Ng I.O.L. and Au Yeung K.M., Osteomyelitis with proliferative periostitis: an unusual case, Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2006, 102(5): 14-19. |
Tung
K.K., Wong C.M. and Ng I.O.L., The tumor suppressive role
of HGF activator inhibitor 2(HAI-2) in hepatocellular carcinoma, Proceedings
of the Annual Meeting of American Association for Cancer Research, |
Wong C.L., Ching Y.P. and Ng I.O.L., Roles and regulations of Rho-kinases in hepatocellular carcinoma, Proceedings of the Annual Meeting of American Association for Cancer Research, Los Angeles, USA, April. 2007. |
Wong C.M., Ng Y.L., Lee M.F., Wong C.L., Cheung O.F., Chan P.C.Y., Tung K.K., Ching Y.P. and Ng I.O.L., Tissue factor pathway inhibitor-2 as a frequently silenced tumor suppressor gene in hepatocellular carcinoma, Hepatology. 2007, 45(5): 1129-1138. |
Yam J.W.P., Ko C.F., Chan C.Y., Jin D. and Ng I.O.L., Interaction of DLC1-tensin2 complex with caveolin-1 and implications in tumor suppression, Cancer Research. 2006, 66: 8367-8372. |
Yam J.W.P., Ko C.F., Chan C.Y., Yau T.O., Tung K.K., Leung T.H.Y., Jin D. and Ng I.O.L., Tensin2 variant 3 is associated with aggressive tumor behavior in human hepatocellular carcinoma, Hepatology. 2006, 44: 881-890. |
Yam J.W.P., Ko C.F., Chan P.C.Y., Yau T.O., Tung K.K., Leung T.H.Y., Jin D. and Ng I.O.L., Tensin2 variant 3 is associated with aggressive tumor behavior in human hepatocellular carcinoma, Queenstown Signal Transduction Meeting, New Zealand. 2006. |
Zhang P., Chan D.W., Zhu Y.Y., Li J.J., Ng I.O.L., Wan D.F. and Gu J.R., Identification of carboxypeptidase of glutamate like-B as a candidate suppressor in cell growth and metastasis in human hepatocellular carcinoma, Clinical Cancer Research. 2006, 12(22): 6617-6625. |
Researcher
: Ng YL |
List of Research Outputs |
Wong C.M., Ng Y.L., Lee M.F., Wong C.L., Cheung O.F., Chan P.C.Y., Tung K.K., Ching Y.P. and Ng I.O.L., Tissue factor pathway inhibitor-2 as a frequently silenced tumor suppressor gene in hepatocellular carcinoma, Hepatology. 2007, 45(5): 1129-1138. |
Researcher
: Nicholls JM |
Project Title: |
ACE and ACE 2 expression in lungs of normal patients and patients with SARS |
Investigator(s): |
Nicholls JM, Peiris JSM, Cheung CY |
Department: |
Pathology |
Source(s) of Funding: |
Small Project Funding |
Start Date: |
09/2005 |
Abstract: |
In December 2002 - June 2003 Southern |
Project Title: |
Sialic acid and receptor expression in normal respiratory tract, H5N1 influenza and non-avian influenza cases |
Investigator(s): |
Nicholls JM, Guan Y, Peiris JSM |
Department: |
Pathology |
Source(s) of Funding: |
Research Fund for the Control of Infectious Diseases - Full Grants |
Start Date: |
10/2005 |
Abstract: |
To determine if there is a change in expression of sialic acids in the conjunctiva and respiratory tract of nornal, avian influenza and fatal non-avian influenza cases that makes infection by the H5N1 more likely in Chinese subjects. |
Project Title: |
Occult respiratory viral infections in coronial autopsies - a pilot project |
Investigator(s): |
Nicholls JM, Peiris JSM, Chan KH, Beh SL, Poon LLM |
Department: |
Pathology |
Source(s) of Funding: |
Research Fund for the Control of Infectious Diseases - Full Grants |
Start Date: |
12/2005 |
Abstract: |
Analyse the presence of clinically undiagnosed respiratory viral infections in autopies performed under HK coronial system |
Project Title: |
Respiratory Syncytial virus and Influenza associated cardiovascular mortality |
Investigator(s): |
Nicholls JM |
Department: |
Pathology |
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
Start Date: |
04/2007 |
Abstract: |
There is an increasing body of knowledge
associating acute and chronic infections with cardiovascular diseases,
principally ischaemic stroke and myocardial infarction (1) and also a
seasonal influence on cardiovascular disease. This has initially been
reported in geographical regions with cold winter climates, such as |
List of Research Outputs |
Chan M.C.W., Chan W.Y., Ho C.C., Nicholls J.M., Cheung C.Y., Chui W.H., Guan Y. and Peiris J.S.M., Polarity of influenza H5N1 virus infection in respiratory epithelial cells and the impact of basolateral release of cytokines in disease pathogenesis, Options for the Control of Influenza VI. 2007. |
Chan M.C.W., Chan W.Y., Cheung C.Y., Nicholls J.M. and Peiris J.S.M., The replication and pathogenicity of influenza A (H5N1) viruses infection in polarized human respiratory epithelium, The American Society For Virology, 25th Annual Meeting. 2006. |
Lee E.H., Chan Y.K., Nicholls J.M., Peiris J.S.M. and Khoo U.S., Sialic acid alpha-2,6-sialyltransferase (SA-alpha-2,6-Gal) Promoter Polymorphism and Gene Expression, MGH-HKU-Nature China Forum, Hong Kong. 2007. |
Ngan E.S.W., Sit Y.L.F., Lee K.Y., Miao X., Yuan Z., Wang W.L., Nicholls J.M., Wong K.K.Y., Garcia-Barcelo M.M., Lui V.C.H. and Tam P.K.H., Implications of endocrine gland - derived vascular endothelial growth factor/prokineticin-1 signaling in human neuroblastoma progression., Clinical Cancer Research. 2007, 13(3): 868-875. |
Nicholls
J.M., Current Trends in Avian Influenza , “, Influenza
Inter-Pandemic Preparedness Plan Episode V” August 3-4, 2006 The |
Nicholls
J.M., Current Trends in Avian Influenza , “Influenza
Inter-Pandemic Preparedness Plan Episode IV” July 6-7, 2006 Long Beach Garden
Hotel & Spa, Chon |
Nicholls
J.M., Current Trends in Avian Influenza, “Influenza
Inter-Pandemic Preparedness Plan Episode V” August 3-4, 2006 The |
Nicholls J.M., Laboratory techniques for Avian Influenza Post-mortems, 2006 Beijing International Symposium and Training Workshop on Pathology and Postmortem of Human Avian Influenza, July 11-12, 2006, 2006. |
Nicholls J.M., Laboratory techniques for Avian Influenza Post-mortems, 2006 Beijing International Symposium and Training Workshop on Pathology and Postmortem of Human Avian Influenza, July 11-12, 2006. |
Nicholls J.M., Oncogene Aspects of Epstein-Barr Virus in relation to Nasopharyngeal Carcinoma, Deuxièmes Journées de Cancérologie, Constantine, Algérie, 12 - 13 September 2006 . 2006. |
Nicholls
J.M. and Peiris
J.S.M., The Role of a Pathology Laboratory in SARS and Other Emerging
Infections, In: |
Nicholls J.M., Chan M.C.W., Chan W.Y., Wong H.K., Kwong D.L.W., Wong M.P., Chui W.H., Poon L.L.M., Tsao G.S.W., Guan Y. and Peiris J.S.M., Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract, Nature Medicine. 2007, 13(2): 147-149. |
Nicholls J.M., Chan M.C.W., Chan W.Y., Wong C.H.K., Cheung C.Y., Kwong D.L., Wong M.P., Chui W.H., Poon L.L.M., Tsao G.S.W., Guan Y. and Peiris J.S.M., Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract, In: Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract, Nature Medicine. 2007, 13(2): 147-9. |
Peiris J.S.M., Guan Y., Poon L.L.M., Cheng V.C.C., Nicholls J.M. and Yuen K.Y., Severe Acute Respiratory Syndrome (SARS), Emerging Infections 7. ASM Press, 2007, N/A: 23-50. |
Roberton S.I., Bell D.J., Smith G.J., Nicholls J.M., Chan K.H., Nguyen D.T., Tran P.Q.,
Streicher U., Poon L.L.M., Chen H., Horby P., Guardo M., Guan Y. and Peiris J.S.M., Avian influenza H5N |
Tse H.F., Siu C.W.D., Zhu S., Liao S., Zhang Q.Y., Lai K.W.H., Nicholls J.M. and Tse H.F., Paracrine effects of direct intramyocardial implantation of bone marrow derived cells for enhancement of neovascularization in chronic ischemic myocardium, European Journal Heart Fail. 2007, 9(8): 747-53. |
Researcher
: Samaranayake YH |
Project Title: |
Genomic basis of fluconazole resistance in C.glabrata |
Investigator(s): |
Samaranayake YH, Samaranayake LP |
Department: |
Dental Faculty |
Source(s) of Funding: |
Small Project Funding |
Start Date: |
11/2004 |
Completion Date: |
10/2006 |
Abstract: |
To obtain a drug resistant C. glabrata strain by sequential exposure to sub-minimal inhibitory concentrations of fluconazole; to determine cell viability (by ATP measurement) after drug exposure and observe the morphological changes by SEM. |
List of Research Outputs |
Researcher
: Shek TWH |
List of Research Outputs |
Au W.Y., Fung T.K., Ma E.S.K., Shek T.W.H., Hawkins B.R. and Liang R.H.S., HLA associations, microsatellite instability and epigenetic changes in thyroid lymphoma in Chinese, Leuk Lymphoma. 2007, 48(3): 531-534. |
Cheuk
D.K.L., Shek T.W.H., Chan G.C.F., Lau Y.L., Ha S.Y. and Chiang A.K.S., Parotid Acinic Cell
Carcinoma in a Long-Term Survivor of Childhood Acute Lymphoblastic Leukemia, Pediatric
Blood Cancer. |
Hon C., Yau K., Shek T.W.H. and Au W.Y., Diffuse large cell B cell lymphoma presenting as a unilateral eye mass, American Journal of Hematology. 2007, 82(4): 325-326. |
Lai L., Hui C.K., Poon R.T.P., Shek T.W.H., Lai S.T., Lai J.Y., Lo C.M., Fan S.T., Leung N. and Lau G., The use of transient elastography as a preoperative assessment of hepatic resection (Abstract), The 17th Asian Pacific Association for the Study of the Liver Conference, Kyoto, Japan, 27 - 30 March 2007. Hepatology International. 2007, 1(1): 51. |
Researcher
: Shek WK |
List of Research Outputs |
Cheung M.S., Shek W.K., Shek W.K., Leung J.C.K., Chan Y.Y., Huang H., Kwong Y.L., Liang R.H.S. and Leung A.Y.H., Aldehyde dehydrogenase activity in leukemic blasts defines a subgroup of acute myeloid leukemia with adverse prognosis and superior NOD/SCID engrafting potential, Leukaemia. 2007, 21: 1423-1430. |
Researcher
: Shen L |
List of Research Outputs |
Chen W.Y.W., Hu X., Liang A.C.T., Au W.Y., So J.C.C., Wong M.L.Y., Shen L., Tao Q., Chu K.M., Kwong Y.L. and Srivastava G., High BCL6 expression predicts better prognosis, independent of BCL6 translocation status, translocation partner, or BCL6 deregulating mutations, in gastric lymphoma, Blood. 2006, 108: 2373-2383. |
Project Title: |
Ectoplasmic specialization dynamics in the testis is regulated by focal adhesion complex-mediated signaling pathways |
Investigator(s): |
|
Department: |
Zoology |
Source(s) of Funding: |
Small Project Funding |
Start Date: |
11/2004 |
Abstract: |
To investigate the downstream signaling pathway(s) underneath integrin and FAK that contribute to the regulation of ES dynamics. |
Project Title: |
p21-activated kinases (Paks) in ovarian and endometrial cancers |
Investigator(s): |
|
Department: |
Pathology |
Source(s) of Funding: |
Small Project Funding |
Start Date: |
01/2006 |
Abstract: |
The purpose of the proposed investigation
is to characterize the expression levels and the signaling pathways of Paks
in ovarian and endometrial cancers in an attempt to explore the roles of Paks
in their carcinogenesis, with potential impacts on the development of
targeted anticancer therapies. Key Issues and Problems being addressed:
Ovarian and endometrial cancers are two common gynecological cancers. In
2002, ovarian cancer ranked eighth among the major causes of cancer death in |
List of Research Outputs |
Au
C.W.H., Siu K.Y., Liao X., Ngan H.Y.S. and Cheung A.N.Y., Tropomyosin-related
kinase B and brain-derived neurotrophic factor in ovarian cancer.
[abstract]., In: American Association for Cancer Research Annual Meeting:
Proceedings; Apr 14-18; |
Chan
K.Y.Q., Ngan H.Y.S., Chan Y.K., Siu K.Y., Chiu P.M., Khoo U.S., Ip P.P.C. and Cheung A.N.Y., Significance of single
nucleotide polymorphism of the metabolizing enzyme NQO |
Chan K.Y.Q., Ngan H.Y.S., Chan Y.K., Siu K.Y., Chiu P.M., Khoo U.S., Ip P.P.C. and Cheung A.N.Y., Single Nucleotide Polymorphism of Metabolizing Enzymes is Associated with Risk of Ovarian Carcinoma in Chinese Women, The 8th International Meeting on Human Genome Variation & Complex Genome Analysis, Hong Kong, 14-16 September. 2006. |
Cheung A.N.Y., Siu K.Y., Au W.H., Chan H.Y. and Wong E.S.Y., Follicle Stimulating Hormone can act on Receptors of Other Growth Hormones, Carcinogenesis. 2007, [Epub ahead of print]. |
Leung T.W., Siu K.Y. and Cheung A.N.Y., Differential Expression
of the Imprinting Gene IPL in Gestational Trophoblastic Diseases: A
Potentially Useful Adjunctive Tool to Differentiate Hydatidiform Moles from
Hydropic Abortions, 13th |
Leung T.W., Siu K.Y., Li A.S., Wong E.S.Y. and Cheung A.N.Y., ΔNp73 expression is a
potentially useful prognostic marker to predict development of persistent
gestational trophoblastic neoplasia requiring chemotherapy in patients
suffering from complete hydatidiform moles. [abstract]., In: American
Association for Cancer Research Annual Meeting: Proceedings; Apr 14-18; |
Li W.M.M., Xia W., Mruk D.D., Wang Q., Yan H.N.H., Siu K.Y., Lui W.Y., Lee W.W.M. and Cheng C.Y., Tumor necrosis factor-alpha reversibly disrupts the blood-testis barrier and impairs Sertoli-germ cell adhesion in the seminiferous epithelium of adult rat testes, Journal of Endocrinology. 2006, 190(2): 313-329. |
Liao X., Xue W.C., Shen D.H., Ngan H.Y.S., Siu K.Y. and Cheung A.N.Y., p63 expression in ovarian tumours: a marker for Brenner tumours but not transitional cell carcinomas., Histopathology. 2007, in press. |
Siu
K.Y., Woo N.W., Wong E.S.Y., Chan H.Y., Ngan H.Y.S. and Cheung A.N.Y., Biological significant of
p21-activated kinase |
Siu
K.Y. and Cheng C.Y., Extracellular matrix and
its role in spermatogenesis, In: Cheng CY, Molecular Mechanisms in
Spermatogenesis. |
Tsun O.K.L., Yeung Y.H., Chan Y.K., Siu K.Y., Szeto E.F., Chan K.Y.Q., Chan K.W. and Cheung A.N.Y., Cervical Cytology Screening in Pregnant Women, International Cancer Congress (13th), Hong Kong, 15 - 17 November 2006. |
Woo N.W.S., Siu K.Y. and Cheung A.N.Y., Immunohistochemical
Analysis of Paks Expression in Ovarian Cancer, 13th |
Researcher
: So ECW |
List of Research Outputs |
Cheung
N., Yam J.W.P., Chan L.C., Cleary M.L. and So E.C.W., Identification of an
oncogene MLL fusion complex with histone methylation and acetylation
activities, 48th Annual Meeting American Society of Haematology, Orlando,
USA. December 9-12. 2006, Blood Vol 108 No. 11 Part 1: |
Researcher
: So JCC |
List of Research Outputs |
Chan Y.Y., So J.C.C., Ma E.S.K. and Chan L.C., A laboratory strategy for genotyping hemoglobin H disease in the Chinese, J Clin Pathol. 2006, 60(8): 931-4. |
Chen W.Y.W., Hu X., Liang A.C.T., Au W.Y., So J.C.C., Wong M.L.Y., Shen L., Tao Q., Chu K.M., Kwong Y.L. and Srivastava G., High BCL6 expression predicts better prognosis, independent of BCL6 translocation status, translocation partner, or BCL6 deregulating mutations, in gastric lymphoma, Blood. 2006, 108: 2373-2383. |
So
J.C.C., A laboratory strategy for molecular
diagnosis of HbH disease in Chinese, 5th Asia Pacific International |
So
J.C.C., Chan A.Y.Y., Tsang S.T.Y., Lee A.C.W., Au W.Y., Ma E.S.K. and Chan L.C., A novel beta-delta globin
gene fusion leads to over-expression of delta globin chain and a mild
thalassemia intermedia phenotype when co-inherited with beta-zero
thalassemia, 48th American Society of Hematology Annual Meeting and
Expositions. 2006, Blood Vol 108 No. 11 Part 1: |
So J.C.C., Chan Y.Y., Tsang S.T.Y., Lee C.W., Au W.Y., Ma E.S.K. and Chan L.C., A novel beta-delta globin gene fusion, anti-Lepore Hong Kong, leads to overexpression of delta globin chain and a mild thalassaemia intermedia phenotype when co-inherited with b0-thalassaemia, British Journal of Haematology. 2006, 136(1): 158-162. |
So
J.C.C., Anti-Lepore Hong Kong – A well-known
stranger, In: Hong Kong Society for the Study of Thalassaemia, |
So J.C.C., Wan T.S.K., Yip S.F., Ma E.S.K., Lam C.C.K. and Chan L.C., Can morphological assessment limit the use of specific genetic testing to exclude chronic myeloid leukaemia?, Br J Haematol. 2007, 137(4): 377. |
Wan T.S.K., So J.C.C., Hui K.C., Yip S.F., Ma E.S.K. and Chan L.C., Diagnostic utility of dual fusion PML/RARalpha translocation DNA probe (D-FISH) in acute promyelocytic leukemia, Oncol Rep. 2007, 17(4): 799-805. |
Yip
S.F., Wan T.S.K., Liu H.S., Wong
M.L., So J.C.C. and Chan L.C., |
Researcher
: Srivastava G |
Project Title: |
Role of CD44 and protein kinase C-binding protein 1, novel translocation partners of immunoglobulin heavy chain gene, in the pathogenesis of gastric lymphoma |
Investigator(s): |
Srivastava G |
Department: |
Pathology |
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
Start Date: |
09/2004 |
Abstract: |
To investigate the role of CD44 and
PRKCBP1. For CD44 study: (1) to determine whether the gene amplification of
CD44 represents another mechanism of CD44 upregulation in GL cases with
strong CD44 expression. (2) to determine whether the hypermethylation of the
promoter region of CD44 gene may be responsible for the downregulation of CD |
Project Title: |
Characterization of the role of immunoglobulin heavy and light chain [kappa] and [lambda] gene translocations in the pathogenesis of gastric lymphoma |
Investigator(s): |
Srivastava G, Liang RHS |
Department: |
Pathology |
Source(s) of Funding: |
Michael Kadoorie Cancer Genetics Research Fund |
Start Date: |
01/2005 |
Abstract: |
To clone IGH-related translocations in GL at both IGHJ and 5' S[mu] region by LDI-PCR and those involving switch region sequences 3' to the S[mu], S[gamma]1-4, and S[alpha]1-2 regions by LDV-PCR; to clone IG[kappa]- and IG[lambda]-related translocations involving the joining region in GL by LDI-PCR; to determine the frequency of the known and novel IG (IGH, IG[kappa], IG[lambda])-related translocations identified by us in GL by direct PCR on genomic DNA; to study the expression of novel IG translocation partner genes in GL by immunostaining to determine whether the over expression of these genes in the tumor cells is associated with the IG translocation of these genes in GL; to determine the mRNA expression of novel IG translocation partner genes in the normal peripheral B-cells and human B-lineage tumor cell lines that correspond to different stages of B-cell development, loss of the normal control mechanisms regulating expression of these novel IG partner genes may contribute to malignant transformation in lymphomas; to analyze the mutations of incoming novel IG translocation partner genes in GL since in B cells, where the somatic hypermutation mechanism is active, mutations of the incoming gene may be observed and may contribute to the neoplastic phenotype; to determine the transforming and tumorigenic potential of each of the overexpressed novel IG translocation partner genes by in vitro growth properties and in vivo tumorigenicity assays; to determine the prevalence of all the cloned novel IG-related translocations identified by us in GL in nodal specimens (MZBCL and DLBCL) by direct PCR, for comparison of IG translocations in gastric MALT and DLBCL with their respective nodal counterparts. |
Project Title: |
Molecular mechanisms and clinicopathological significance of the aberrant nuclear BCL10 expression and constitutive NF-[kappa]B activation in EBV-associated nasal NK/T-cell lymphoma |
Investigator(s): |
Srivastava G, Liang RHS |
Department: |
Pathology |
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
Start Date: |
10/2005 |
Abstract: |
To analyze BCL10 and NF-χB expression in
the cytoplasmic and nuclear protein fractions prepared from normal NK cells,
NL specimens and NK tumor cell lines by Western blot analysis NF-χB transfer
from cytoplasm to nucleus is the hallmark of its activation; to determine
whether the nuclear localization of BCL |
Project Title: |
To identify tumor suppressor genes in the commonly deleted region of 6q in nasal NK/T-cell lymphoma by employing array-CGH and epigenetic approach |
Investigator(s): |
Srivastava G, Liang RHS, Tao Q |
Department: |
Pathology |
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
Start Date: |
03/2006 |
Abstract: |
Putative natural killer (NK) cell
lymphoma/leukemia is a rare group of recently characterized hematolymphoid
malignancies. They are highly aggressive and frequently present in extranodal
sites, including the nasal area and the upper aerodigestive system, and
non-nasal areas such as the skin and the gastrointestinal tract. By
clinicopathological features, they can be classified into nasal NK/T-cell
lymphoma (NL), nasal-type NK/T-cell lymphoma occurring in non-nasal areas,
and NK cell lymphoma/leukemia. Primary NL represent the second most frequent
group of extra-nodal lymphomas in Hong Kong Chinese. They are reported mostly
from Asia, |
Project Title: |
Therapeutic potential and mechanisms of antitumor activity of proteasome inhibitor bortezomib in extranodal NK/T-cell lymphoma, nasal type |
Investigator(s): |
Srivastava G, Liang RHS |
Department: |
Pathology |
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
Start Date: |
09/2006 |
Abstract: |
To examine whether bortezomib promotes apoptosis and inhibits cell growth in vitro in a large series of NK lymphoma/leukemia cell lines and extranodal NK/T-cell lymphoma, nasal type (NL) primary cultures by analyzing cell viability, cell senescence, cell cycle and apoptosis; (2) to investigate whether bortezomib is effective in treating NL in vivo, we will study the effect of bortezomib on the treatment of NL NUDE mouse model HX-NKTL. In addition, two NL cell lines will be implanted subcutaneously in nude mice to provide tumor xenograft animal models, including HANKI1 that is a xenograft-derived NL cell line. The drug will be injected intravenously to determine its effectiveness; (3) bortezomib directly affects two important intracellular signaling pathways-NF-κB and JNK that are shown to be regulated by ubiquitin-proteasome degradation in multiple myeloma cells. We will investigate whether this anticancer drug works by the similar molecular mechanisms in NL; (4) to further understand the mechanisms of antitumor action of bortezomib, we will examine the molecules associated with the G2/M checkpoint because we detected G2/M arrest in a drug-treated NL cell line in a pilot study; (5) because the drug induced apoptosis in most of the analyzed cell lines and mitochondria are belived to play a crucial role in the control of apoptosis, apoptotic signaling molecules, especially those located in mitochondria, will be analyzed to uncover their involvement with the action of bortezomib; we will explore the essential molecular changes in the early stages of drug action. Superoxide production and intracellular Ca2+ dysregulation may be the critical determinants, so we will identify their roles in the bortezomib-induced apoptosis pathways. |
List of Research Outputs |
Chen W.Y.W., Hu X., Liang A.C.T., Au W.Y., So J.C.C., Wong M.L.Y., Shen L., Tao Q., Chu K.M., Kwong Y.L. and Srivastava G., High BCL6 expression predicts better prognosis, independent of BCL6 translocation status, translocation partner, or BCL6 deregulating mutations, in gastric lymphoma, Blood. 2006, 108: 2373-2383. |
Cheung C.M., Tang J.C.O., Lee P.Y., Hu L., Guan X.Y., Srivastava G., Wong J., Luk J.M.C. and Law S.Y.K., Establishment and characterization of a new xenograft-derived human esophageal squamous cell carcinoma cell line HKESC-4 of chinese origin, 11th Research Postgraduate Symposium (11th RPS), The University of Hong Kong Li Ka Shing Faculty of Medicine, Hong Kong, 7 December. 2006. |
Guo T., Wong K.Y., Chen Y. and Srivastava G., Indentification of tumor suppressor gene candidates in the commonly deleted region of chromosome 6q in extranodal NK/T-cell lymphoma, nsal type, 11th Research Postgraduate Symposium (11th RPS), The University of Hong Kong Li Ka Shing Faculty of Medicine, Hong Kong, 7 December. 2006. |
Iqbal J., Geng H., DeLeeuw R.J., Patel
K., Lam W.L., Dybkaer K., Shimizu N., Srivastava
G. and Chan W.C., Anaylsis of Gene Expression Patterns and Gene Copy
Number Changes in Human NK Cell Malignancies, Blood (ASH Annual Meeting
Abstracts). 2006, 108(11): |
Jin H., Wang X., Ying J., Wong A.H., Li H., Lee K.Y., Srivastava G., Chan A.T., Yeo W., Ma B.B., Putti T.C., Lung M.L., Shen Z.Y., Xu L.Y., Langford C. and Tao Q., Epigenetic identification of ADAMTS18 as a novel 16q23.1 tumor suppressor frequently silenced in esophageal, nasopharyngeal and multiple other carcinomas, Oncogene. 2007, [Epub ahead of print]. |
Seng T.J., Low J.S., Li H., Cui Y., Goh H.K., Wong M.L.Y., Srivastava G., Sidransky D., Califano J., Steenbergen R.D., Rha S.Y., Tan J., Hsieh W.S., Ambinder R.F., Lin X., Chan A.T. and Tao Q., The major 8p22 tumor suppressor DLC1 is frequently silenced by methylation in both endemic and sporadic nasopharyngeal, esophageal, and cervical carcinomas, and inhibits tumor cell colony formation, Oncogene. 2007, 26(6): 934-44. |
Srivastava G., Editor of International Journal of Medical Sciences. Ivyspring International Publisher, 2006. |
Tang W.K., Chui C.H., Fatima S., Kok S.H., Pak K.C., Ou T.M., Hui K.S., Wong M.M., Wong J., Law S.Y.K., Tsao G.S.W., Lam K.Y., Beh P.S., Srivastava G., Ho K.P., Chan A.S. and Tang J.C.O., Inhibitory effects of gleditsia sinensis fruit extract on telomerase activity and oncogenic expression in human esophageal squamous cell carcinoma, International Journal of Molecular Medicine. 2007, 19(6): 953-960. |
Tang W.K., Chui C.H., Fatima S., Kok S.H., Pak K.C., Ou T.M., Hui K.S., Wong M.M., Wong J., Law S.Y.K., Tsao G.S.W., Lam K.Y., Beh P.S., Srivastava G., Chan A.S., Ho K.P. and Tang J.C.O., Oncogenic properties of a novel gene JK-1 located in chromosome 5p and its overexpression in human esophageal squamous cell carcinoma, International Journal of Molecular Medicine. 2007, 19(6): 915-923. |
Ying J., Gao Z., Li H., Srivastava G., Murray P.G., Lim C.Y., Wang Y., Marafioti T., Mason D.Y., Ambinder R.F., Chan A.T. and Tao Q., Frequent epigenetic silencing of protocadherin 10 by methylation in multiple haematologic malignancies, British Journal of Hematology. 2007, 136(6): 829-32. |
Ying J., Li H., Murray P., Chen W.Y.W., Wang Y., Lee K.Y., Chan A.T., Ambinder R.F., Srivastava G. and Tao Q., Tumor-specific methylation of the 8p22 tumor suppressor gene DLC1 is an epigenetic biomarker for Hodgkin, nasal NK/T-cell and other types of lymphomas, Epigenetics. 2007, 2(1): 15-21. |
Yuen H.F., Chan Y.P., Wong M.L.Y., Kwok W.K., Chan K.K., Lee P.Y., Srivastava G., Law S.Y.K., Wong Y.C., Wang X. and Chan K.W., Upregulation of Twist in oesophageal squamous cell carcinoma is associated with neoplastic transformation and distant metastasis, Journal of Clinical Pathology. 2006, 60(5): 510-514. |
Researcher
: Szeto EF |
List of Research Outputs |
Tsun O.K.L., Yeung Y.H., Chan Y.K., Siu K.Y., Szeto E.F., Chan K.Y.Q., Chan K.W. and Cheung A.N.Y., Cervical Cytology Screening in Pregnant Women, International Cancer Congress (13th), Hong Kong, 15 - 17 November 2006. |
Researcher
: Tam S |
List of Research Outputs |
Au W.Y., Tsang S.K., Cheung B.K., Siu T.S., Ma E.S.K. and Tam S., Cough mixture abuse as a novel cause of folate deficiency: a prospective, community-based, controlled study, Haematologica. 2007, 92(4): 562-563. |
Ho M.H.K., Chow P.C., Lee T.L., Tam S., Wong W.H.S., Wong W.K.H.S., Lau Y.L. and Cheung Y.F., Carotid Intima-Media Thickening in Adolescents and Young Adults with Paediatric-Onset Systemic Lupus Erythematosus is Not Related to Traditional and Novel Cardiovascular Risk Factors, 2nd Congress of Asian Society for Pediatric Research (ASPR), Yokohama, Japan, 8-10 December 2006. 157. |
Lam J.C., Tam S., Ooi C.G.C., Ku P.P., Lai A.Y.K., Lam B., Lam K.S.L. and Ip M.S.M., Relationship between
sympathetic activity, obesity, and obstructive sleep apnea, 8th World
Congress on Sleep Apnea. |
Lam J.C.M., Tam S., Ooi C.G.C., Ku P.P., Lai A.Y.K., Lam B., Lam K.S.L. and Ip M.S.M., Relationship between
sympathetic activity, obesity, and obstructive sleep apnea, 8th World
Congress on Sleep Apnea. |
Lui
S.L., Yung S.S.Y., Tsang R.C.W., Chan K.W., Zhang Q., Tam S., Lai K.N. and Chan D.T.M., Rapamycin attenuates the
severity of nephritis in NZB/NZW mice, Journal of the American Society of
Nephrology. 2006, 17: |
Lui
S.L., Yung S.S.Y., Tsang R.C.W., Chan K.W., Zhang Q., Tam S., Lai K.N. and Chan D.T.M., Rapamycin reduces
proteinuria and segmental glomerulosclerosis in murine adriamycin
nephropathy, Journal of the American Society of Nephrology. 2006, 17: |
List of Research Outputs |
Chan
T.L., Yuen S.T., Kong C.K., Chan Y.W., Chan A.S.Y., Ng W.F., Tsui W.Y., Lo M.W.S., Tam W.Y., Li V.S.W. and Leung S.Y., Heritable germline
epimutation of MSH |
Researcher
: Tam YSI |
List of Research Outputs |
Leung L.H., Chung L.P., Tam Y.S.I., Tin P.C. and Wong M.P., Src kinase pathway is a potential candidate for molecular targeted therapy of non-small cell lung cancers (NSCLC) that show exon 19 deletion mutation or other epidermal growth factor (EGFR) abnormalities., AACR annual meeting 2007, Los Angeles, CA. 2007, 301. |
Tam Y.S.I., EGFR Mutations and NSCLC in |
Tam Y.S.I., Leung L.H., Chung L.P. and Wong M.P., EGFR with L858R and H870R
double mutations showed reduced sensitivity to Gefitinib., AACR annual
meeting 2007, |
Tam Y.S.I., Leung L.H., Chung L.P. and Wong M.P., Germline EGFR mutation is
uncommon and plays a limited role in predisposition to lung cancer., AACR
annual meeting 2007, |
Zhu H., Tam Y.S.I. and Wong M.P., EGFR mutations and targeted therapy in non-small cell lung cancer., EGFR 突變與非小細胞肺癌酪氨酸激酶抑制劑靶向治療, CJBC. 2007, 14(2): 105-9. |
Zhu H., Tam Y.S.I. and Wong M.P., Egfr Mutations And Targeted Therapy In Non-small Cell Lung Cancer , EGFR突变与非小细胞肺癌酪氨酸激酶抑制剂靶向治疗, Chinese Journal of Cancer Biotherapy. 中国肿瘤生物治疗杂志, 2007, 14(2): 105-109. |
Researcher
: Tang JCO |
List of Research Outputs |
Tang W.K., Chui C.H., Fatima S., Kok S.H., Pak K.C., Ou T.M., Hui K.S., Wong M.M., Wong J., Law S.Y.K., Tsao G.S.W., Lam K.Y., Beh P.S., Srivastava G., Ho K.P., Chan A.S. and Tang J.C.O., Inhibitory effects of gleditsia sinensis fruit extract on telomerase activity and oncogenic expression in human esophageal squamous cell carcinoma, International Journal of Molecular Medicine. 2007, 19(6): 953-960. |
Tang W.K., Chui C.H., Fatima S., Kok S.H., Pak K.C., Ou T.M., Hui K.S., Wong M.M., Wong J., Law S.Y.K., Tsao G.S.W., Lam K.Y., Beh P.S., Srivastava G., Chan A.S., Ho K.P. and Tang J.C.O., Oncogenic properties of a novel gene JK-1 located in chromosome 5p and its overexpression in human esophageal squamous cell carcinoma, International Journal of Molecular Medicine. 2007, 19(6): 915-923. |
Researcher
: Tao Q |
List of Research Outputs |
Chen W.Y.W., Hu X., Liang A.C.T., Au W.Y., So J.C.C., Wong M.L.Y., Shen L., Tao Q., Chu K.M., Kwong Y.L. and Srivastava G., High BCL6 expression predicts better prognosis, independent of BCL6 translocation status, translocation partner, or BCL6 deregulating mutations, in gastric lymphoma, Blood. 2006, 108: 2373-2383. |
Jin H., Wang X., Ying J., Wong A.H., Li H., Lee K.Y., Srivastava G., Chan A.T., Yeo W., Ma B.B., Putti T.C., Lung M.L., Shen Z.Y., Xu L.Y., Langford C. and Tao Q., Epigenetic identification of ADAMTS18 as a novel 16q23.1 tumor suppressor frequently silenced in esophageal, nasopharyngeal and multiple other carcinomas, Oncogene. 2007, [Epub ahead of print]. |
Seng T.J., Low J.S., Li H., Cui Y., Goh H.K., Wong M.L.Y., Srivastava G., Sidransky D., Califano J., Steenbergen R.D., Rha S.Y., Tan J., Hsieh W.S., Ambinder R.F., Lin X., Chan A.T. and Tao Q., The major 8p22 tumor suppressor DLC1 is frequently silenced by methylation in both endemic and sporadic nasopharyngeal, esophageal, and cervical carcinomas, and inhibits tumor cell colony formation, Oncogene. 2007, 26(6): 934-44. |
Ying J., Gao Z., Li H., Srivastava G., Murray P.G., Lim C.Y., Wang Y., Marafioti T., Mason D.Y., Ambinder R.F., Chan A.T. and Tao Q., Frequent epigenetic silencing of protocadherin 10 by methylation in multiple haematologic malignancies, British Journal of Hematology. 2007, 136(6): 829-32. |
Ying J., Li H., Murray P., Chen W.Y.W., Wang Y., Lee K.Y., Chan A.T., Ambinder R.F., Srivastava G. and Tao Q., Tumor-specific methylation of the 8p22 tumor suppressor gene DLC1 is an epigenetic biomarker for Hodgkin, nasal NK/T-cell and other types of lymphomas, Epigenetics. 2007, 2(1): 15-21. |
Researcher
: Tin PC |
List of Research Outputs |
Lam C.L., Girard L., Suen W.S., Chung L.P., Tin P.C., Lam W.K., Minna J.D. and Wong M.P., Establishment and expression profiling of new lung cancer cell lines from Chinese smokers and life-time never-smokers, Journal of Thoracic Oncology. 2006, 1: 932-942. |
Leung L.H., Chung L.P., Tam Y.S.I., Tin P.C. and Wong M.P., Src kinase pathway is a potential candidate for molecular targeted therapy of non-small cell lung cancers (NSCLC) that show exon 19 deletion mutation or other epidermal growth factor (EGFR) abnormalities., AACR annual meeting 2007, Los Angeles, CA. 2007, 301. |
Researcher
: To KW |
List of Research Outputs |
To
K.W., Wong
O.H., Li H.B., Chen S.F., Lo C.K.,
Chiang A.K.S. and Huang F., Effects Of Bergapten On
Dendritic Cell Functions, The 9th International Syposium on Dendritic
Cells, |
List of Research Outputs |
Au W.Y., Trendell-Smith N.J., Chow C. and Liang R.H.S., Senile EBER positive diffuse large B cell lymphoma relapsing in the nasopharynx, Haematologica. 2006, 91(1): 111. |
Researcher
: Tsang HM |
List of Research Outputs |
Tsang
H.M., Kong
C.T., Sham M.H. and Chan L.C., Analysis of Mll-Een Fusion
Gene in Mouse Leukemic Model, Keystone Symposium - Mouse Models at the
Frontiers of Cancer Discovery. Whistler Resort, Whistler, |
Researcher
: Tsang STY |
List of Research Outputs |
So
J.C.C., Chan A.Y.Y., Tsang S.T.Y.,
Lee A.C.W., Au W.Y., Ma E.S.K. and Chan L.C., A novel beta-delta globin
gene fusion leads to over-expression of delta globin chain and a mild
thalassemia intermedia phenotype when co-inherited with beta-zero
thalassemia, 48th American Society of Hematology Annual Meeting and
Expositions. 2006, Blood Vol 108 No. 11 Part 1: |
So J.C.C., Chan Y.Y., Tsang S.T.Y., Lee C.W., Au W.Y., Ma E.S.K. and Chan L.C., A novel beta-delta globin gene fusion, anti-Lepore Hong Kong, leads to overexpression of delta globin chain and a mild thalassaemia intermedia phenotype when co-inherited with b0-thalassaemia, British Journal of Haematology. 2006, 136(1): 158-162. |
List of Research Outputs |
Chan Y.K., Tse Y.T., Chan S.Y., Liu W., Garcia-Barcelo M.M., Sham P.C. and Khoo U.S., Estrogen receptors genetic polymorphisms risk association and their functional roles in breast cancer risk: a study on Hong Kong Chinese women, 100th American Association for Cancer Research Annual Meeting, Los Angeles, CA, USA . 2007, Abstract no. 5269. |
Tse Y.T., Chan Y.K., Chan S.Y., Xu M.S., Sham P.C. and Khoo U.S., Estorgen Receptors Genes and
Breast cancer Risk in Chinese: A Haplotype-based Analysis, International
Cancer Congress (13th), |
List of Research Outputs |
Chan
T.L., Yuen S.T., Kong C.K., Chan Y.W., Chan A.S.Y., Ng W.F., Tsui W.Y., Lo M.W.S., Tam W.Y., Li V.S.W. and Leung S.Y., Heritable germline
epimutation of MSH |
Chan
T.L., Yuen S.T., Lo M.W.S., Lee T.Y.H., Kong C.K., Chan Y.W., Tsui W.Y., Li V.S.W., Chan A.S.Y. and Leung S.Y., Study of the mechanisms
underlying heritable germline epimutation of MSH |
Guo D., Yuen S.T., Tsui W.Y., Chan A.S.Y., Chan T.L. and Leung S.Y., Expression of wnt signaling target genes in colorectal cancer progression, Proceedings of the 98th Annual Meeting of the American Association for Cancer Research. 2007. |
Li V.S.W., Yuen S.T., Chan A.S.Y., Tsui W.Y., Chen X. and Leung S.Y., Investigation of signaling pathways that regulate human colon crypt maturation and their dysregulation in tumorigenesis, Proceedings of the 98th Annual Meeting of the American Association for Cancer Research . 2007. |
Researcher
: Tsun OKL |
List of Research Outputs |
Tsun O.K.L., Yeung Y.H., Chan Y.K., Siu K.Y., Szeto E.F., Chan K.Y.Q., Chan K.W. and Cheung A.N.Y., Cervical Cytology Screening in Pregnant Women, International Cancer Congress (13th), Hong Kong, 15 - 17 November 2006. |
Researcher
: Tung KK |
List of Research Outputs |
Tung K.K., Wong C.M. and Ng I.O.L., The tumor suppressive role of
HGF activator inhibitor 2(HAI-2) in hepatocellular carcinoma, Proceedings
of the Annual Meeting of American Association for Cancer Research, |
Wong C.M., Ng Y.L., Lee M.F., Wong C.L., Cheung O.F., Chan P.C.Y., Tung K.K., Ching Y.P. and Ng I.O.L., Tissue factor pathway inhibitor-2 as a frequently silenced tumor suppressor gene in hepatocellular carcinoma, Hepatology. 2007, 45(5): 1129-1138. |
Yam J.W.P., Ko C.F., Chan C.Y., Yau T.O., Tung K.K., Leung T.H.Y., Jin D. and Ng I.O.L., Tensin2 variant 3 is associated with aggressive tumor behavior in human hepatocellular carcinoma, Hepatology. 2006, 44: 881-890. |
Yam J.W.P., Ko C.F., Chan P.C.Y., Yau T.O., Tung K.K., Leung T.H.Y., Jin D. and Ng I.O.L., Tensin2 variant 3 is associated with aggressive tumor behavior in human hepatocellular carcinoma, Queenstown Signal Transduction Meeting, New Zealand. 2006. |
Researcher
: Tung KK |
List of Research Outputs |
Tung K.K., Wong C.M. and Ng I.O.L., The tumor suppressive role of
HGF activator inhibitor 2(HAI-2) in hepatocellular carcinoma, Proceedings
of the Annual Meeting of American Association for Cancer Research, |
Wong C.M., Ng Y.L., Lee M.F., Wong C.L., Cheung O.F., Chan P.C.Y., Tung K.K., Ching Y.P. and Ng I.O.L., Tissue factor pathway inhibitor-2 as a frequently silenced tumor suppressor gene in hepatocellular carcinoma, Hepatology. 2007, 45(5): 1129-1138. |
Yam J.W.P., Ko C.F., Chan C.Y., Yau T.O., Tung K.K., Leung T.H.Y., Jin D. and Ng I.O.L., Tensin2 variant 3 is associated with aggressive tumor behavior in human hepatocellular carcinoma, Hepatology. 2006, 44: 881-890. |
Yam J.W.P., Ko C.F., Chan P.C.Y., Yau T.O., Tung K.K., Leung T.H.Y., Jin D. and Ng I.O.L., Tensin2 variant 3 is associated with aggressive tumor behavior in human hepatocellular carcinoma, Queenstown Signal Transduction Meeting, New Zealand. 2006. |
Researcher
: Wan TSK |
List of Research Outputs |
So J.C.C., Wan T.S.K., Yip S.F., Ma E.S.K., Lam C.C.K. and Chan L.C., Can morphological assessment limit the use of specific genetic testing to exclude chronic myeloid leukaemia?, Br J Haematol. 2007, 137(4): 377. |
Wan T.S.K., So J.C.C., Hui K.C., Yip S.F., Ma E.S.K. and Chan L.C., Diagnostic utility of dual fusion PML/RARalpha translocation DNA probe (D-FISH) in acute promyelocytic leukemia, Oncol Rep. 2007, 17(4): 799-805. |
Yip
S.F., Wan T.S.K., Liu
H.S., Wong M.L., So J.C.C. and Chan L.C., |
Yip S.F., Wan T.S.K., Liu H.S., Wong M.L. and Chan L.C., The Philadelphia-Chromosome is unmasked as the secondary genetic change in acute myeloid leukemia on imatinib treatment, 48th Annual Meeting American Society of Haematology, Orlando, USA. December 9-12 . 2006, Blood Vol 108 No. 11 Part 2: 219b. |
Researcher
: Wang X |
Project Title: |
Downregulation of MAD2 expression and its significance in chemodrug sensitization in nasopharyngeal carcinoma cells |
Investigator(s): |
Wang X, Nicholls JM, Tsao GSW, Jin D |
Department: |
Anatomy |
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
Start Date: |
09/2003 |
Abstract: |
To confirm that MAD2 expression is downregulated in clinical samples of NPC; to determine the mechanism by which MAD2 is downregulated in NPC; to establish whether upregulation of MAD2 expression can sensitize NPC cells to chemotherapy. |
Project Title: |
The role fo MAD |
Investigator(s): |
Wang X, Jin D |
Department: |
Anatomy |
Source(s) of Funding: |
Lance Armstrong Foundation - General Award |
Start Date: |
10/2003 |
Abstract: |
To investigate the association between
decreased MAD2 protein expression and cisplatin resistance in TGCT cells; to
study if exogenous expression of the MAD2 gene in TGCT cells can lead to
chemosensitization to cisplatin in TGCT cells; to demonstrate that
downregulation of MAD2 results in resistance ot cisplatin in TGCT cells; to
characterize the role of MAD |
Project Title: |
Significance of MAD2 expression to chromosomal instability in prostate cancer |
Investigator(s): |
Wang X, Jin D Y |
Department: |
Anatomy |
Source(s) of Funding: |
Association for International Cancer Research - General Award |
Start Date: |
04/2004 |
Abstract: |
To correlate MAD2 expression with genomic instability in prostate cancer specimens; to show that MAD2 expression is essential for a functional mitotic checkpoint in prostate cancer cells; to demonstrate that downregulation of MAD2 leads to mitotic checkpoint defect and increased CIN in prostate cancer cells. • To investigate if promoter hypermethylation contributes to decreased MAD2 expression in prostate cancer |
Project Title: |
Molecular mechanisms involved in the suppressive effects of garlic derivatives on cell growth and motility in prostate cancer cells |
Investigator(s): |
Wang X, Jin D Y |
Department: |
Anatomy |
Source(s) of Funding: |
American Institute for Cancer Research (AICR) - General Award |
Start Date: |
08/2005 |
Abstract: |
To study the role of the mitotic checkpoint in SAC and SAMC-induced androgen independent prostate cancer cell death; to investigate if SAC and SAMC have any inhibitory effect on the invasive ability of prostate cancer cells and to determine the molecular mechanisms responsible. Specific Aim 3. To examine if SAC and SAMC can enhance the sensitivity of prostate cancer cells to chemotherapeutic drugs. |
Project Title: |
Significance of Id-1 upregulation and its association with EGFR in bladder cancer |
Investigator(s): |
Wang X |
Department: |
Anatomy |
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
Start Date: |
06/2006 |
Abstract: |
Background: Bladder cancer is one of the
common urological cancers. Although majority of bladder cancers are
superficial at presentation, 20% of the bladder cancer patients present with
muscle invasive disease at diagnosis (i.e. stage T2-T4 tumours). If
untreated, fewer than 15% of those patients can survive more than two years.
Two main challenges remain for the treatment of this cancer which are (i) the
ability to identify the small but significant number of patients with
non-muscle-invasive disease who will progress to muscle-invasive disease, and
(ii) to improve current treatment of the muscle invasive bladder cancer.
Recently, our group identified a potential oncogene, Id-1 (inhibitor of
differentiation or DNA binding), and demonstrated its significance in the
development of human prostate cancer (Ouyang et al., J Urol 167: 2598, 2002),
nasopharyngeal carcinoma (Wang et al., 35:42-49, 2002) and ovarian cancer
(Zhang et al., Br J Cancer 91: 2042, 2004). Since then, upregulation of Id-1
has been reported in over 20 types of human cancer such as breast, pancreas,
cervical, melanoma, and head and neck (Reviewed by Wong et al., 9:279-289,
2004). In addition, increased Id-1 expression levels are associated with
advanced tumour stage as well as poor prognosis (Maruyama et al., Am J Pathol
155: 815, 1999; Schindl et al., Cancer Res 61: 5703, 2001; Ouyang et al., J
Urol 167: 2598, 2002). Furthermore, patients with higher levels of Id-1 have
much shorter overall survival than the patients with relatively lower Id-1
expression in ovarian cancer (Schindl et al., Clin Cancer Res 9:779, 2003).
Recent evidence also shows that Id-1 is able to induce epidermal growth
factor receptor (EGFR) expression, indicating that the oncogenic effect of
Id-1 may be mediated through activation of the EGFR pathway (Ling et al.,
Carcinogenesis 25: 517, 2004; Zhang et al., Br J Cancer 91: 2042, 2004). In
bladder cancer, upregulation of EGFR has been frequently reported in tissue
samples (Neal et al., Lancet 1: 366, 1985; Mellon et al., J Urol 153: 919,
1995). Several studies have correlated EGFR positively with tumour stage,
tumour progression, and poor clinical outcome in bladder cancer patients
(Neal et al., Cancer 65: 1619, 1990; Mellon et al., J Urol 153: 919, 1995;
Nguyen et al., Am J Clin Pathol 101: 166, 1994). Furthermore, it was recently
reported that treatment of bladder cancer cells with ZD1839 (or Iressa), a
highly selective EGFR inhibitor, resulted in radiosensitization to ionizing
radiation (Maddineni et al., Br J Cancer 92: 125, 2005), indicating that EGFR
may be a potential therapeutic target in improving treatment efficiency of
bladder cancer. Based on the evidence that Id-1 is able to activate EGFR
pathway, we hypothesized that activation of the EGFR pathway observed in
bladder cancer may be a result of overexpression of Id-1, as indicated in
other cancers (Ling et al., Carcinogenesis 25: 517, 2004; Zhang et al., Br J
Cancer 91: 2042, 2004 ). Purpose of the project: The aim of this project is
to study the significance of Id |
List of Research Outputs |
Researcher
: Wong CHK |
List of Research Outputs |
Nicholls J.M., Chan M.C.W., Chan W.Y., Wong C.H.K., Cheung C.Y., Kwong D.L., Wong M.P., Chui W.H., Poon L.L.M., Tsao G.S.W., Guan Y. and Peiris J.S.M., Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract, In: Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract, Nature Medicine. 2007, 13(2): 147-9. |
Researcher
: Wong CL |
List of Research Outputs |
Wong C.L., Ching Y.P. and Ng I.O.L., Roles and regulations of Rho-kinases in hepatocellular carcinoma, Proceedings of the Annual Meeting of American Association for Cancer Research, Los Angeles, USA, April. 2007. |
Wong C.M., Ng Y.L., Lee M.F., Wong C.L., Cheung O.F., Chan P.C.Y., Tung K.K., Ching Y.P. and Ng I.O.L., Tissue factor pathway inhibitor-2 as a frequently silenced tumor suppressor gene in hepatocellular carcinoma, Hepatology. 2007, 45(5): 1129-1138. |
Researcher
: Wong CM |
Project Title: |
Genetic and
epigenetic alterations of serine protease inhibitor TFPI |
Investigator(s): |
Wong CM, Ng IOL |
Department: |
Pathology |
Source(s) of Funding: |
Small Project Funding |
Start Date: |
10/2005 |
Abstract: |
Liver cancer is a major malignancy in the
world and is particularly prevalent in this region, being the second most
common fatal cancer in Asia including |
List of Research Outputs |
Tung
K.K., Wong C.M. and Ng I.O.L., The tumor suppressive role of
HGF activator inhibitor 2(HAI-2) in hepatocellular carcinoma, Proceedings
of the Annual Meeting of American Association for Cancer Research, |
Wong C.M., Ng Y.L., Lee M.F., Wong C.L., Cheung O.F., Chan P.C.Y., Tung K.K., Ching Y.P. and Ng I.O.L., Tissue factor pathway inhibitor-2 as a frequently silenced tumor suppressor gene in hepatocellular carcinoma, Hepatology. 2007, 45(5): 1129-1138. |
Researcher
: Wong ESY |
List of Research Outputs |
Cheung A.N.Y., Siu K.Y., Au W.H., Chan H.Y. and Wong E.S.Y., Follicle Stimulating Hormone can act on Receptors of Other Growth Hormones, Carcinogenesis. 2007, [Epub ahead of print]. |
Leung T.W., Siu K.Y., Li A.S., Wong E.S.Y. and Cheung A.N.Y., ΔNp73 expression is a
potentially useful prognostic marker to predict development of persistent
gestational trophoblastic neoplasia requiring chemotherapy in patients
suffering from complete hydatidiform moles. [abstract]., In: American
Association for Cancer Research Annual Meeting: Proceedings; Apr 14-18; |
Siu
K.Y., Woo N.W., Wong E.S.Y.,
Chan H.Y., Ngan H.Y.S. and Cheung A.N.Y., Biological significant of
p21-activated kinase |
List of Research Outputs |
Guo T., Wong K.Y., Chen Y. and Srivastava G., Indentification of tumor suppressor gene candidates in the commonly deleted region of chromosome 6q in extranodal NK/T-cell lymphoma, nsal type, 11th Research Postgraduate Symposium (11th RPS), The University of Hong Kong Li Ka Shing Faculty of Medicine, Hong Kong, 7 December. 2006. |
Ma S.K.Y., Guan X.Y., Beh S.L., Wong K.Y., Chan Y.P., Yuen H.F., Vielkind J. and Chan K.W., The significance of LMO2 expression in the progression of prostate cancer, The Journal of Pathology. 2006, 211(3): 278-85. |
Researcher
: Wong MLY |
List of Research Outputs |
Chen W.Y.W., Hu X., Liang A.C.T., Au W.Y., So J.C.C., Wong M.L.Y., Shen L., Tao Q., Chu K.M., Kwong Y.L. and Srivastava G., High BCL6 expression predicts better prognosis, independent of BCL6 translocation status, translocation partner, or BCL6 deregulating mutations, in gastric lymphoma, Blood. 2006, 108: 2373-2383. |
Seng T.J., Low J.S., Li H., Cui Y., Goh H.K., Wong M.L.Y., Srivastava G., Sidransky D., Califano J., Steenbergen R.D., Rha S.Y., Tan J., Hsieh W.S., Ambinder R.F., Lin X., Chan A.T. and Tao Q., The major 8p22 tumor suppressor DLC1 is frequently silenced by methylation in both endemic and sporadic nasopharyngeal, esophageal, and cervical carcinomas, and inhibits tumor cell colony formation, Oncogene. 2007, 26(6): 934-44. |
Yuen H.F., Chan Y.P., Wong M.L.Y., Kwok W.K., Chan K.K., Lee P.Y., Srivastava G., Law S.Y.K., Wong Y.C., Wang X. and Chan K.W., Upregulation of Twist in oesophageal squamous cell carcinoma is associated with neoplastic transformation and distant metastasis, Journal of Clinical Pathology. 2006, 60(5): 510-514. |
Researcher
: Wong MP |
Project Title: |
Identification of candidate cancer genes in regions of frequent chromosomal aberration in non-small cell lung cancers |
Investigator(s): |
Wong MP, Chung LP, Lam WK |
Department: |
Pathology |
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
Start Date: |
09/2003 |
Abstract: |
To define critical regions of imbalance in frequently altered chromosomal loci identified in local samples of non-small cell lung cancers (NSCLC) by microstatellite analysis; to identify target genes in the analyzed regions by comparison with genes listed in databases of the Human Genome Resources(NCBI); to study the structure and expression of the targeted genes in NSCLC of smokers and non-smokers, so as to verify their involvement and to look for genetic or epigenetic alterations. |
Project Title: |
Differentially expressed genes in lung cancer |
Investigator(s): |
Wong MP, Chung LP, Lam WK |
Department: |
Pathology |
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
Start Date: |
01/2005 |
Abstract: |
To verify whether molecular targets identified through expression profile microarray screening procesures truly show aberrant expressions in extended samples of lung cancers; to evaluate whether the genes encoding these verified molecular targets show alterations or mutations, so that their primary roles in carcinogenesis are supported at the genomic level. |
Project Title: |
Mutational Analysis of Epidermal Growth Factor Receptor in Non-Small Cell Lung Cancer |
Investigator(s): |
Wong MP, Chua DTT |
Department: |
Pathology |
Source(s) of Funding: |
Small Project Funding |
Start Date: |
11/2005 |
Abstract: |
A. Purpose of study: To evaluate the
incidence and patterns of EGFR mutation in NSCLC, and to correlate the
findings with clinicopathological characteristics as well as clinical
responses of the patients to gefitinib therapy. B. Problem being addressed
and Key Issues: • Non-small cell lung cancer (NSCLC) is a common cancer in |
Project Title: |
Significance of Circulating Tumour Cells and Serum Nucleic Acid Markers in Non-small Cell Lung Cancer |
Investigator(s): |
Wong MP, Chua DTT, Ho JCM |
Department: |
Pathology |
Source(s) of Funding: |
Small Project Funding |
Start Date: |
11/2006 |
Abstract: |
Purpose of Study To investigate the
usefulness of circulating tumour cells, and serum EGFR mutant and expression
level as tumour markers for evaluating chemotherapy treatment options and
predicting tumour outcome in patients with non-small cell lung cancer. Key
issues In Hong Kong, the incidence and mortality
rates of lung cancer are high for both men and women. It is the commonest
cancer in men and, as in Western populations, tobacco smoking is the main
cause. It is the 2nd commonest cancer in women. However, most female lung
cancer patients are life-long non-smokers and, passive smoking, air pollution,
cooking habits and genetic influences have been suggested as etiological
factors (1). The overall prognosis of lung cancer depends on the tumour
stage, with relatively good outcome of >50% 5 year survival for stage I
patients, and poor outcome with <15% 5 year survival for late stage patients. Tumour markers embrace different forms of indicators that can be detected in the peripheral circulation which are postulated to reflect the systemic load of tumour cells within the body. Measurement of the tumour markers at different stages of tumour progression may provide useful information on the status of the tumour, e.g. residual or recurrent disease. It is hypothesized that these may correlate with the patient outcome and prognosis. Different treatment options have recently become available for patients with lung cancer. For late stage (IIIB and IV) tumours, palliative tumour reduction by chemotherapy and/or radiotherapy is used. New molecular targeted therapy using tyrosine kinase inhibitors (TKI) that antagonize epidermal growth factor receptor (EGFR) signalling has led to promising results in patients whose tumours harbour activating EGFR mutations or increased EGFR expression. EGFR mutations have been found in >70%
of female non-smokers and about 20% of male smokers in our local population
(2). The high frequencies of these abnormalities implicate that EGFR mutants
or expression level could be used as potential markers to detect tumour cells
in the peripheral blood for monitoring systemic spread of lung cancer. In view of the poor patient prognosis, and because of the
diversity of treatment options available, it is important that clinicians are
able to predict the likely outcome and monitor the treatment response of
patients with lung cancers. Currently, apart from the tumour stage, few, if
any, definitive prognostic indicators are known.
Two forms of tumour markers have been investigated in recent years, namely,
circulating tumour cells (CTC) and serum nucleic acids of specific molecules.
CTC are tumour cells that have become detached from the parent tumour and
entered into the peripheral circulation. They are present in variable
quantities in different patients but by using the appropriate technology,
their numbers can be quantified. In experiments targeted to investigate the
relation between the actual spiked and detected number of tumour cells in
controlled samples, a linear and significant correlation between the two was
shown for a range from 5 to about 1200 tumour cells in the samples. In
clinical studies, the numbers of CTC have been shown to be a useful indicator
of survival in patients with metastatic breast cancer (3). Very few studies
of CTC in lung cancers have been reported. Gauthier et al, who used electromagnetic
separation to isolate tumour cells and TRAP-assay to measure their telomerase
activity, found CTC in 11/15 (73%) of stage IIIB and IV non-small cell lung
cancer patients compared to 0/30 healthy controls (4). Kraeft et al detected
fluorescent anti-epithelial antibody-labeled CTC in 18/40 (45%) of
centrifuged blood from small cell lung cancer patients (5). However, the
relation of CTC to tumour stage, patient survival and response to treatment
has not been reported. Circulating serum RNA of various
molecules has been analyzed in lung cancer patients, such as hnRNP-B1, CEA,
Her2, TTF1, etc. Fleischhacker et al were able to detect circulating RNA for
hnRNP-B1 and/or Her |
List of Research Outputs |
Ho J.C.M., Chan M.M.W., Ho S.P., Mak J.C.W., Ip M.S.M., Ooi C.G.C., Wong M.P., Tsang K.W.T. and Lam W.K., Disturbance of systemic antioxidant profile in non-small cell lung carcinoma, Eur Respir J . 2007, 29: 273-278. |
Ho J.C.M., Wong M.P. and Lam W.K., Invited review: Lymphoepithelioma-like carcinoma of the lung, Respirology. 2006, 11(5): 539-545. |
Lam B., Wong M.P., Fung S.L., Lam C.L., Wong P.C., Wong T.Y.W., Lam F.M., Ip M.S.M., Ooi C.G.C. and Lam W.K., The clinical value of autofluorescence bronchoscopy for the diagnosis of lung cancer , European Respiratory Journal. 2006, 28(5): 915-919. |
Lam C.L., Girard L., Suen W.S., Chung L.P., Tin P.C., Lam W.K., Minna J.D. and Wong M.P., Establishment and expression profiling of new lung cancer cell lines from Chinese smokers and life-time never-smokers, Journal of Thoracic Oncology. 2006, 1: 932-942. |
Lam C.L., Girard L., Ramirez R., Chau W.S., Suen W.S., Sheridan S., Tin V.P., Chung L.P., Wong M.P., Shay J.W., Gazdar A.F., Lam W.K. and Minna J.D., Expression of nicotinic acetylcholine receptor subunit genes in non small cell lung cancer reveals differences between smokers and nonsmokers, Cancer Research. 2007, 67(10): 4638-4647. |
Lam C.L., Girard L., Ramirez R., Chau W.S., Suen W.S., Sheridan S., Tin V.P.C., Chung L.P., Wong M.P., Shay J.W., Gazdar A.F., Lam W.K. and Minna J.D., Nicotinic acetylcholine receptor subunit genes showed difference in expression pattern in smokers and nonsmokers , Annual Meeting of the American Association of Cancer Research. 2007, AACR abstracts: 2430. |
Leung L.H., Chung L.P., Tam Y.S.I., Tin P.C. and Wong M.P., Src kinase pathway is a potential candidate for molecular targeted therapy of non-small cell lung cancers (NSCLC) that show exon 19 deletion mutation or other epidermal growth factor (EGFR) abnormalities., AACR annual meeting 2007, Los Angeles, CA. 2007, 301. |
Leung L.H., Chung L.P. and Wong M.P., Src kinase pathway is a potential candidate for molecular targeted therapy of non-small cell lung cancers (NSCLC) that show exon 19 deletion mutation or other epidermal growth factor receptor (EGFR) abnormalities , American Association for Cancer Research Annual Meeting, Los Angeles, California, the United State . 2007. |
Leung L.H., Chung L.P. and Wong M.P., Src kinase-a potential drug target in treating non-small cell lung cancer (NSCLC), 1st Annual John R. Murren Memorial Symposium: Advances in Thoracic Oncology, Yale Continuing Medical Education and Nevada Cancer Institute, Las Vegas, Nevada, USA . 2007. |
Nicholls J.M., Chan M.C.W., Chan W.Y., Wong H.K., Kwong D.L.W., Wong M.P., Chui W.H., Poon L.L.M., Tsao G.S.W., Guan Y. and Peiris J.S.M., Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract, Nature Medicine. 2007, 13(2): 147-149. |
Shames D.S., Girard L., Gao B., Sato M., Lewis C.M., Shivapurkar N., Jiang A., Perou C.M., Kim Y.H., Pollack J.R., Fong K.M., Lam C.L., Wong M.P., Shyr Y., Nanda R., Olopade O.I., Gerald W., Euhus D.M., Shay J.W., Gazdar A.F. and Minna J.D., A genome-wide screen for promoter methylation in lung cancer identifies novel methylation markers for multiple malignancies, PLoS Med. 2006, 3(12): e486. |
Tam
Y.S.I., Leung L.H., Chung L.P. and Wong M.P., EGFR with L858R and H870R
double mutations showed reduced sensitivity to Gefitinib., AACR annual
meeting 2007, |
Tam Y.S.I., Leung L.H., Chung L.P. and Wong M.P., Germline EGFR mutation is uncommon and plays a limited role in predisposition to lung cancer., AACR annual meeting 2007, Los Angeles, CA. 2007, 32. |
Wong
M.P., Egfr Mutations And Targeted Therapy In
Non-small Cell Lung Cancer, 5th |
Wong M.P., Src Kinase Pathway Is A Potential Candidate For Molecular Targeted Therapy Of Non-small Cell Lung Cancers (nsclc) That Show Exon 19 Deletion Mutation Or Other Epidermal Growth Factor Receptor (egfr) Abnormalities, The Croucher Foundation Advanced Study Institute, “Molecular Genetics and Cell Signaling in Cancer and Cancer Metastasis” . 2007. |
Zhu H., Tam Y.S.I. and Wong M.P., EGFR mutations and targeted therapy in non-small cell lung cancer., EGFR 突變與非小細胞肺癌酪氨酸激酶抑制劑靶向治療, CJBC. 2007, 14(2): 105-9. |
Zhu H., Tam Y.S.I. and Wong M.P., Egfr Mutations And Targeted Therapy In Non-small Cell Lung Cancer , EGFR突变与非小细胞肺癌酪氨酸激酶抑制剂靶向治疗, Chinese Journal of Cancer Biotherapy. 中国肿瘤生物治疗杂志, 2007, 14(2): 105-109. |
Researcher
: Xu H |
List of Research Outputs |
Ching Y.P., Leong V.Y.L., Lee M.F., Xu H., Jin D. and Ng I.O.L., P21-activated protein kinase is overexpressed in hepatocellular carcinoma and enhances cancer metastasis involving c-Jun NH2-terminal kinase activation and paxillin phosphorylation. , Cancer Research. 2007, 67: 3601-3608. |
Researcher
: Xu MS |
List of Research Outputs |
Tse
Y.T., Chan Y.K., Chan S.Y., Xu M.S., Sham P.C. and Khoo U.S., Estorgen Receptors Genes and
Breast cancer Risk in Chinese: A Haplotype-based Analysis, International
Cancer Congress (13th), |
Researcher
: Xue W |
List of Research Outputs |
Chan K.Y.Q., Ngan H.Y.S., Ip P.P.C., Liu V.W.S., Xue W. and Cheung A.N.Y., Follistatin-like 1 is important for ovarian and endometrial carcinogenesis – a differential expression and functional analysis, 98th Annual Meeting of American Association for Cancer Research, 14-18 April. 2007. |
Tam K.F., Cheung A.N.Y., Liu S., Xue W. and Ngan H.Y.S., Expression of Matrix Metalloproteinases and tissue inhibitors of metalloproteinases in atypical complex endometrial hyperplasia with and without associated malignancy, XVIII FIGO World Congress, Kuala Lumpur, Malaysia, 5-10 Nov. 2006. |
Wang Y., Liu V.W.S., Xue W., Cheung A.N.Y. and Ngan H.Y.S., Association of decreased mitochondrial DNA content with ovarian cancer progression , British Journal of Cancer. 2006, 95: 1087-1097. |
Wang Y., Xue W., Liu V.W.S. and Ngan H.Y.S., Detection of Mosaic Pattern of Mitochondrial DNA Alterations in Different Populations of Cells from the Same Endometrial Tumor, Mitochondrion. Elsevier, 2007, 7: 171-175. |
Yang C., Chan Y.K., Ngan H.Y.S., Khoo U.S., Chiu P.M., Chan Q.K.Y., Xue W. and Cheung A.N.Y., Single nucleotide polymorphisms of follicle-stimulating hormone receptor are associated with ovarian cancer susceptibility, Carcinogenesis. 2006, 27: 1502-6. |
Researcher
: Xue W |
List of Research Outputs |
Chan K.Y.Q., Ngan H.Y.S., Ip P.P.C., Liu V.W.S., Xue W. and Cheung A.N.Y., Follistatin-like 1 is important for ovarian and endometrial carcinogenesis – a differential expression and functional analysis, 98th Annual Meeting of American Association for Cancer Research, 14-18 April. 2007. |
Tam K.F., Cheung A.N.Y., Liu S., Xue W. and Ngan H.Y.S., Expression of Matrix Metalloproteinases and tissue inhibitors of metalloproteinases in atypical complex endometrial hyperplasia with and without associated malignancy, XVIII FIGO World Congress, Kuala Lumpur, Malaysia, 5-10 Nov. 2006. |
Wang Y., Liu V.W.S., Xue W., Cheung A.N.Y. and Ngan H.Y.S., Association of decreased mitochondrial DNA content with ovarian cancer progression , British Journal of Cancer. 2006, 95: 1087-1097. |
Wang Y., Xue W., Liu V.W.S. and Ngan H.Y.S., Detection of Mosaic Pattern of Mitochondrial DNA Alterations in Different Populations of Cells from the Same Endometrial Tumor, Mitochondrion. Elsevier, 2007, 7: 171-175. |
Yang C., Chan Y.K., Ngan H.Y.S., Khoo U.S., Chiu P.M., Chan Q.K.Y., Xue W. and Cheung A.N.Y., Single nucleotide polymorphisms of follicle-stimulating hormone receptor are associated with ovarian cancer susceptibility, Carcinogenesis. 2006, 27: 1502-6. |
Researcher
: Yam JWP |
Project Title: |
Characterization of tensin2, the binding partner of DLC1 tumor suppressor in liver cancer |
Investigator(s): |
Yam JWP, Ng IOL, Jin D |
Department: |
Pathology |
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
Start Date: |
01/2007 |
Abstract: |
To verify the DLC1-tensin2 interaction;
to determine the impact of DLC1-tensin2 interaction on their biochemical
properties; to delineate the biological functions of tensin2 and its
implications in HCC; to evaluate the clinicopathological significance of
tensin |
Project Title: |
Nucleocytoplasmic shuttling mechanism of DLC1 tumor suppressor in liver cancer |
Investigator(s): |
Yam JWP, Ng IOL |
Department: |
Pathology |
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
Start Date: |
01/2007 |
Abstract: |
Purpose of the proposed investigation The
purpose of this study is to elucidate how the subcellular localization of
DLC1 (Deleted in Liver Cancer 1) determines its cellular functions. The
spatial distribution of a protein is tightly regulated and correlated to
proper functioning of a protein. Here we hypothesize that DLC1 shuttles
between cytoplasm and nucleus, which in turn regulates its tumor suppressive
functions. Objectives 1) To elucidate the nucleocytoplasmic shuttling
mechanism of DLC1 2) To delineate the distinctive functional roles of DLC |
List of Research Outputs |
Chan D.W., Chan P.C.Y., Yam J.W.P., Ching Y.P. and Ng I.O.L., Prickle-1 negatively regulates wnt/beta-catenin pathway by promoting dishevelled ubiquitination/degradation in liver cancer, Gastroenterology. USA, Elsevier Inc, 2006, 131: 1218-1227. |
Cheung
N., Yam J.W.P., Chan L.C., Cleary M.L. and So E.C.W., Identification of an oncogene
MLL fusion complex with histone methylation and acetylation activities, 48th
Annual Meeting American Society of Haematology, Orlando, USA. December 9-12.
2006, Blood Vol 108 No. 11 Part 1: |
Leung
T.H.Y., Ching Y.P., Yam J.W.P. and Ng I.O.L., DLC2 (deleted in liver cancer
2) suppresses cell growth via the regulation of p70S6K, Queenstown
Molecular Biology |
Yam J.W.P., Focal adhesion proteins in cancer metastasis, Hong Kong International Cancer Congress . 2006. |
Yam J.W.P., Ko C.F., Chan C.Y., Jin D. and Ng I.O.L., Interaction of DLC1-tensin2 complex with caveolin-1 and implications in tumor suppression, Cancer Research. 2006, 66: 8367-8372. |
Yam J.W.P., Tensin2 variant 3 Is associated with aggressive tumor behavior in human hepatocellular carcinoma, The University of Hong Kong - Centre for Cancer Research. 2006. |
Yam J.W.P., Ko C.F., Chan C.Y., Yau T.O., Tung K.K., Leung T.H.Y., Jin D. and Ng I.O.L., Tensin2 variant 3 is associated with aggressive tumor behavior in human hepatocellular carcinoma, Hepatology. 2006, 44: 881-890. |
Yam J.W.P., Ko C.F., Chan P.C.Y., Yau T.O., Tung K.K., Leung T.H.Y., Jin D. and Ng I.O.L., Tensin2 variant 3 is associated with aggressive tumor behavior in human hepatocellular carcinoma, Queenstown Signal Transduction Meeting, New Zealand. 2006. |
Researcher
: Yang C |
List of Research Outputs |
Yang C., Chan Y.K., Ngan H.Y.S., Khoo U.S., Chiu P.M., Chan Q.K.Y., Xue W. and Cheung A.N.Y., Single nucleotide polymorphisms of follicle-stimulating hormone receptor are associated with ovarian cancer susceptibility, Carcinogenesis. 2006, 27: 1502-6. |
Researcher
: Yau TO |
Project Title: |
The role of Frizzled-7, receptor of the WNT/β-catenin signalling pathway, in hepatocellular carcinoma: Implications in tumorigenesis and metastasis |
Investigator(s): |
Yau TO, Ng IOL |
Department: |
Pathology |
Source(s) of Funding: |
Small Project Funding |
Start Date: |
10/2006 |
Abstract: |
Hepatocellular carcinoma (HCC) is second
commonest in Asia and in |
List of Research Outputs |
Chan K.C., Yau T.O., Ng I.O.L. and Chung S.K., Deleted in liver cancer 2 (DLC2) knockout mice show fast response to heat induced-pain, 11th Postgraduate symposium 2006, Hong Kong. 2006. |
Hui
C.F., Yau T.O., Ching Y.P. and Ng I.O.L., Rapamycin and CCI-779 suppress
the growth of hepatocellular carcinoma cells, Proceedings of the Annual
Meeting of American Association for Cancer Research, |
Yam J.W.P., Ko C.F., Chan C.Y., Yau T.O., Tung K.K., Leung T.H.Y., Jin D. and Ng I.O.L., Tensin2 variant 3 is associated with aggressive tumor behavior in human hepatocellular carcinoma, Hepatology. 2006, 44: 881-890. |
Yam J.W.P., Ko C.F., Chan P.C.Y., Yau T.O., Tung K.K., Leung T.H.Y., Jin D. and Ng I.O.L., Tensin2 variant 3 is associated with aggressive tumor behavior in human hepatocellular carcinoma, Queenstown Signal Transduction Meeting, New Zealand. 2006. |
Researcher
: Yeung CW |
List of Research Outputs |
Ip P.P.C., Lam K.W., Yeung C.W., Pun T.C., Chan K.Y.Q. and Cheung A.N.Y., Tranexamic Acid Associated Necrosis and Intra-lesional Thrombosis of Uterine Leiomyomas: A clinicopathologic study of 490 Cases Emphasizing the Importance of Drug-induced Necrosis, Montreal IAP, 16-21 September. 2006. |
Researcher
: Yip SF |
List of Research Outputs |
So J.C.C., Wan T.S.K., Yip S.F., Ma E.S.K., Lam C.C.K. and Chan L.C., Can morphological assessment limit the use of specific genetic testing to exclude chronic myeloid leukaemia?, Br J Haematol. 2007, 137(4): 377. |
Wan T.S.K., So J.C.C., Hui K.C., Yip S.F., Ma E.S.K. and Chan L.C., Diagnostic utility of dual fusion PML/RARalpha translocation DNA probe (D-FISH) in acute promyelocytic leukemia, Oncol Rep. 2007, 17(4): 799-805. |
Yip
S.F., Wan
T.S.K., Liu H.S., Wong M.L., So
J.C.C. and Chan L.C., |
Yip S.F., Wan T.S.K., Liu H.S., Wong M.L. and Chan L.C., The Philadelphia-Chromosome is unmasked as the secondary genetic change in acute myeloid leukemia on imatinib treatment, 48th Annual Meeting American Society of Haematology, Orlando, USA. December 9-12 . 2006, Blood Vol 108 No. 11 Part 2: 219b. |
Researcher
: Yuen HF |
List of Research Outputs |
Fung K.L., Cheung H.W., Wong H.L., Yuen H.F., Ling M.T., Chan K.W., Wong Y.C., Cheung A. and Wang X., MAD2 expression and its significance in mitotic checkpoint control in testicular germ cell tumour. , Biochimica et Biophysica Acta - Molecular Cell Research . 2007, 1773: 821-832. |
Ma S.K.Y., Guan X.Y., Beh S.L., Wong K.Y., Chan Y.P., Yuen H.F., Vielkind J. and Chan K.W., The significance of LMO2 expression in the progression of prostate cancer, The Journal of Pathology. 2006, 211(3): 278-85. |
Yuen
H.F., Chua
C.W., Chan Y.P., Wong Y.C., Wang X. and Chan K.W., Id proteins expression in
prostate cancer: high-level expression of Id |
Yuen H.F., Chua C.W., Chan Y.P., Wong Y.C., Wang X. and Chan K.W., Significance of TWIST and E-cadherin expression in the metastatic progression of prostatic cancer, Histopathology. 2007, 50(5): 648-58. |
Yuen H.F., Chan Y.P., Wong Y.C., Wang X. and Chan K.W., The prognostic significance of Id proteins in Esophageal Squamous Cell Carcinoma, The 97th American Association of Cancer Research Annual Meeting, Los Angeles, USA, April. 2007. |
Yuen H.F., Chan Y.P., Wong M.L.Y., Kwok W.K., Chan K.K., Lee P.Y., Srivastava G., Law S.Y.K., Wong Y.C., Wang X. and Chan K.W., Upregulation of Twist in oesophageal squamous cell carcinoma is associated with neoplastic transformation and distant metastasis, Journal of Clinical Pathology. 2006, 60(5): 510-514. |
Researcher
: Yuen HF |
List of Research Outputs |
Fung K.L., Cheung H.W., Wong H.L., Yuen H.F., Ling M.T., Chan K.W., Wong Y.C., Cheung A. and Wang X., MAD2 expression and its significance in mitotic checkpoint control in testicular germ cell tumour. , Biochimica et Biophysica Acta - Molecular Cell Research . 2007, 1773: 821-832. |
Ma S.K.Y., Guan X.Y., Beh S.L., Wong K.Y., Chan Y.P., Yuen H.F., Vielkind J. and Chan K.W., The significance of LMO2 expression in the progression of prostate cancer, The Journal of Pathology. 2006, 211(3): 278-85. |
Yuen
H.F., Chua
C.W., Chan Y.P., Wong Y.C., Wang X. and Chan K.W., Id proteins expression in
prostate cancer: high-level expression of Id |
Yuen H.F., Chua C.W., Chan Y.P., Wong Y.C., Wang X. and Chan K.W., Significance of TWIST and E-cadherin expression in the metastatic progression of prostatic cancer, Histopathology. 2007, 50(5): 648-58. |
Yuen H.F., Chan Y.P., Wong Y.C., Wang X. and Chan K.W., The prognostic significance of Id proteins in Esophageal Squamous Cell Carcinoma, The 97th American Association of Cancer Research Annual Meeting, Los Angeles, USA, April. 2007. |
Yuen H.F., Chan Y.P., Wong M.L.Y., Kwok W.K., Chan K.K., Lee P.Y., Srivastava G., Law S.Y.K., Wong Y.C., Wang X. and Chan K.W., Upregulation of Twist in oesophageal squamous cell carcinoma is associated with neoplastic transformation and distant metastasis, Journal of Clinical Pathology. 2006, 60(5): 510-514. |
List of Research Outputs |
Chan
T.L., Yuen S.T., Kong
C.K., Chan Y.W., Chan A.S.Y., Ng W.F., Tsui W.Y., Lo M.W.S., Tam W.Y., Li V.S.W. and Leung S.Y., Heritable germline
epimutation of MSH |
Chan
T.L., Yuen S.T., Kong
C.K., Chan Y.W., Chan A.S.Y. and Leung S.Y., Heritable germline
epimutation of MSH |
Chan T.L., Guo D., Yuen S.T., Chan Y.W., Chan A.S.Y. and Leung S.Y., Immunohistochemical staining on tissue microarray of colorectal cancers constitutes a convenient means to rapidly screen for MMR deficiency, The Second Biennial Scientific Meeting of the International Society for Gastrointestinal Hereditary Tumours, InSiGHT, March 27-30, 2007, Yokohama, Japan. 2007. |
Chan
T.L., Yuen S.T., Lo M.W.S., Lee T.Y.H., Kong C.K., Chan Y.W., Tsui W.Y., Li V.S.W., Chan A.S.Y. and Leung S.Y., Study of the mechanisms
underlying heritable germline epimutation of MSH |
Edkins S., O'meara S., Parker A., Stevens C., Reis M., Jones S., Greenman C., Davies H., Dalgliesh G., Forbes S., Hunter C., Smith R., Stephens P., Goldstraw P., Nicholson A., Chan T.L., Velculescu V.E., Yuen S.T., Leung S.Y., Stratton M.R. and Futreal A., Recurrent KRAS Codon 146 Mutations in Human Colorectal Cancer, Cancer Biology & Therapy. 2006, 5(8): 928-932. |
Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G., Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A. and Stratton M.R., Patterns of somatic mutation in human cancer genomes, Nature. 2007, 446 (7132): 153-8. |
Guo D., Yuen S.T., Tsui W.Y., Chan A.S.Y., Chan T.L. and Leung S.Y., Expression of wnt signaling target genes in colorectal cancer progression, Proceedings of the 98th Annual Meeting of the American Association for Cancer Research. 2007. |
Leung S.Y., Chan T.L. and Yuen S.T., Reply to "Heritable germline epimutation is not the same as transgenerational epigenetic inheritance", Nat Genet. 2007, 39(5): 576. |
Li V.S.W., Yuen S.T., Chan A.S.Y., Tsui W.Y., Chen X. and Leung S.Y., Investigation of signaling pathways that regulate human colon crypt maturation and their dysregulation in tumorigenesis, Proceedings of the 98th Annual Meeting of the American Association for Cancer Research . 2007. |
Sheng J.Q., Chan T.L., Chan Y.W., Huang J.S., Chen J.G., Zhang M.Z., Guo X.L., Mu H., Chan A.S.Y., Li S.R., Yuen S.T. and Leung S.Y., Microsatellite instability and novel mismatch repair gene mutations in northern Chinese population with Hereditary non-polyposis colorectal cancer, Chin J Dig Dis . 2006, 7(4): 197-205. |
Zou B., Chim J.C.S., Zeng H., Leung S.Y., Yang Y., Tu S., Lin M.C., Wang J., He H., Jiang S.H., Sun Y., Yu L., Yuen S.T., Kung H.F. and Wong B.C.Y., Correlation Between the Single-site CpG Methylation and Expression Silencing of the XAF1 Gene in Human Gastric and Colon Cancers, Gastroenterology. 2006, 131(6): 1835-1843. |
Researcher
: Zhang M |
List of Research Outputs |
Ko K.H., Lam Q.L.K., Zhang M., Wong C.K.Y., Lo K.C., Kahmeyer-Gabbe M., Tsang W.H., Tsang S.L., Chan L.C., Sham M.H. and Lu L., Hoxb3 deficiency impairs B lymphopoiesis in mouse bone marrow, Experimental Hematology. 2007, 35(3): 465-75. |
Researcher
: Zhu H |
List of Research Outputs |
Zhu H., Tam Y.S.I. and Wong M.P., EGFR mutations and targeted therapy in non-small cell lung cancer., EGFR 突變與非小細胞肺癌酪氨酸激酶抑制劑靶向治療, CJBC. 2007, 14(2): 105-9. |
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