DEPT OF CLINICAL ONCOLOGY

Researcher : Au GKH



List of Research Outputs

 

Chua D.T.T., Ma J., Sham J.S.T., Mai H.Q., Choy D.T.K., Hong M.H., Lu T.X., Au G.K.H. and Min H.Q., Improvement of survival after addition of induction chemotherapy to radiotherapy in patients with early-stage nasopharyngeal carcinoma: Subgroup analysis of two Phase III trials. , International Journal of Radiation Oncology Biology Physcis. 2006, 65(5): 1300-1306.

 

Chua D.T.T., Sham J.S.T., Hung K.N., Leung H.T. and Au G.K.H., Predictive factors of tumor control and survival after radiosurgery of local failures of nasopharyngeal carcinoma., International Journal of Radiation Oncology Biology Physcis. 2006, 66: 1415-1421.

 

Researcher : Bi J



List of Research Outputs

 

Xu F.P., Xie D., Wen J.M., Wu H.X., Liu Y.D., Bi J., Lv Z.L., Zeng Y.X. and Guan X.Y., SRC-3/AIB1 protein and gene amplification levels in human esophageal squamous cell carcinomas. , Cancer Letter. 2007, 245: 69-74.

 

Researcher : Choy DTK



List of Research Outputs

 

Chua D.T.T., Ma J., Sham J.S.T., Mai H.Q., Choy D.T.K., Hong M.H., Lu T.X., Au G.K.H. and Min H.Q., Improvement of survival after addition of induction chemotherapy to radiotherapy in patients with early-stage nasopharyngeal carcinoma: Subgroup analysis of two Phase III trials. , International Journal of Radiation Oncology Biology Physcis. 2006, 65(5): 1300-1306.

 

Researcher : Chua DTT



List of Research Outputs

 

Baujat B., Audry H., Bourhis J., Chan A.T., Onat H., Chua D.T.T., Kwong D.L.W., Al-Saraff M., Chi K., Hareyama M., Leung S.F., Thephamongkhol K. and Pignon J., Chemotherapy as an adjunct to radiotherapy in locally advanced nasopharyngeal carcinoma., Cochrane Database Systemic Review. 2006, CD004329.

 

Chua D.T.T., A Single-center Experience of Capecitabine as Palliative Chemotherapy in Nasopharyngeal Carcinoma. Update on Nasopharyngeal Carcinoma, Joint Annual Scientific Meeting of The Hong Kong Nasopharyngeal Cancer Study Group and The Hong Kong Head and Neck Society. 2006.

 

Chua D.T.T., Editor, Clinical Medicine: Oncology. 2007.

 

Chua D.T.T., Ma J., Sham J.S.T., Mai H.Q., Choy D.T.K., Hong M.H., Lu T.X., Au G.K.H. and Min H.Q., Improvement of survival after addition of induction chemotherapy to radiotherapy in patients with early-stage nasopharyngeal carcinoma: Subgroup analysis of two Phase III trials. , International Journal of Radiation Oncology Biology Physcis. 2006, 65(5): 1300-1306.

 

Chua D.T.T., Improving Management of Nasopharyngeal Carcinoma., Fifth Roche Asia Oncology Forum. 2006.

 

Chua D.T.T., Late Complications Following Radiotherapy for Intraoral Cancers., First World Congress of International Academy of Oral Oncology. 2007.

 

Chua D.T.T., Sham J.S.T., Hung K.N., Leung H.T. and Au G.K.H., Predictive factors of tumor control and survival after radiosurgery of local failures of nasopharyngeal carcinoma., International Journal of Radiation Oncology Biology Physcis. 2006, 66: 1415-1421.

 

Chua D.T.T., Recent Advances in the Treatment of Nasopharyngeal Carcinoma, Eighth National Congress on Nasopharyngeal Carcinoma. 2007.

 

Chua D.T.T., The Role of Radiotherapy in the Management of Head and Neck Cancer., Cancer Imaging Conference 2007. 2007.

 

Chua D.T.T., Treatment Approaches for Locally Recurrent Nasopharyngeal Carcinoma., 11th Annual Scientific Symposium of the Hong Kong Cancer Institute. 2006.

 

Ji M.F., Wang D.K., Yu Y.L., Guo Y.Q., Liang J.S., Cheng W.M., Zong Y.S., Chan K.H., Ng S.P., Wei W.I., Chua D.T.T., Sham J.S.T. and Ng M.H., Sustained elevation of Epstein-Barr virus antibody levels preceding clinical onset of nasopharyngeal carcinoma., British Journal of Cancer. 2007, 96: 623-630.

 

Khoo U.S., Liu W., Long J.R., Yip S.P., Cheung A.N.Y., Chua D.T.T., Chan S.Y., Ngan H.Y.S., Zheng W. and Chan Y.K., The functional -969C/T promoter polymorphism in BRCA1 decreases breast cancer risk in Chinese women, 100th American Association for Cancer Research Annual Meeting, Los Angeles, CA, USA. 2007, Abstract no.1721.

 

Lee A.W.M., Tung S.Y., Chan A.T.C., Chappell R., Fu Y.T., Lu T.X., Tan T., Chua D.T.T., O'Sullivan B., Xu L., Pang E.S.Y., Sze W.M., Leung T.W., Kwan W.H., Chan P.T.M., Liu X.F., Tan E.H., Sham J.S.T., Siu L. and Lau W.H., Preliminary results of a prospective randomized study (NPC-9902 Trial) on the therapeutic gain by concurrent chemotherapy and/or accelerated fractionation for locally-advanced nasopharyngeal carcinoma, International Journal of Radiation Oncology Biology Physcis. 2006, 66: 142-151.

 

Lee D.C.W., Chua D.T.T., Sham J.S.T., Wei W.I. and Lau A.S.Y., Differential induction of matrix metallo-proteinase 3 by Epstein-Barr virus latent membrane protein 1, Organisation for Oncology and Translational Research 3rd Annual Conference, Hong Kong Academy of Medicine (Neoadjuvant & Molecular Therapy in Cancer), 22-23 September 2006.

 

Lee D.C.W., Chua D.T.T., Sham J.S.T. and Lau A.S.Y., Epstein-Barr virus latent membrane protein 1 enhances matrix metalloproteinase 3 induction in human fibroblast, The 6th International Cytokine Conference 2006 (European Cytokine Network, Supplement Aug 2006, Vol 17 - as official journal of Cytokine 2006-Vienna), Vienna, Austria, 27-31 August 2006. 17: 14-06/P.

 

Lee D.C.W., Chua D.T.T., Sham J.S.T. and Lau A.S.Y., Expression of Matrix Metallo-proteinase 3 by Epstein-Barr Virus Latent Membrane Protein 1, 6th International Cytokine Conference Proceedings, Medimond International Proceedings, Bologna, Italy, 27-31 August 2006. 101-104.

 

Lung H.L., Cheung A.K.L., Xie D., Cheng Y., Kwong F.M., Murakami Y., Guan X.Y., Sham J.S.T., Chua D.T.T., Protopopov A.I., Zabarovsky E.R., Tsao G.S.W., Stanbridge E.J. and Lung M.L., TSLC1 is a tumor suppressor gene associated with metastasis in nasopharyngeal carcinoma, Cancer Research. 2006, 66(19): 9385-9392.

 

Teo P.M., Leung S.F., Tung S.Y., Zee B., Sham J.S.T., Lee A.W.M., Lau W.H., Kwan W.H., Leung T.W. and Chua D.T.T., Dose-response relationship of nasopharyngeal carcinoma above conventional tumoricidal level: a study by the Hong Kong nasopharyngeal carcinoma study group (HKNPCSG), Radiotherapy Oncology. 2006, 79: 227-33.

 

Yau W.L., Lung H.L., Zabarovsky E.R., Lerman M.I., Sham J.S.T., Chua D.T.T., Tsao G.S.W., Stanbridge E.J. and Lung M.L., Functional studies of the chromosome 3p21.3 candidate tumor suppressor gene BLU/ZMYND10 in nasopharyngeal carcinoma, International Journal of Cancer. 2006, 119: 2821-2826.

 

Researcher : Fan Z



List of Research Outputs

 

Wang L.D., Qin Y., Fan Z., Kwong D.L.W., Guan X.Y., Tsao G.S.W., Sham J., Li J.L. and Feng X.S., Comparative genomic hybridization: comparison between esophageal squamous cell carcinoma and gastric cardia adenocarcinoma from a high-incidence area for both cancers in Henan, northern China., Diseases of Esophagus. 2006, 19: 459-467.

 

Researcher : Guan XY



Project Title:

Isolation of genes related to the pathogenesis of hepatocellular carcinoma and nasopharyngeal carcinoma: identification of the association between amplication of oncogenes and cancer prognosis

Investigator(s):

Guan XY

Department:

Clinical Oncology

Source(s) of Funding:

Matching Fund for NSFC Young Researcher Award

Start Date:

05/2001

 

Abstract:

To study isolation of genes related to the pathogenesis of hepatocellular carcinoma and nasopharyngeal carcinoma: identification of the association between amplication of oncogenes and cancer prognosis.

 

Project Title:

Basic research for the mechanisms of development and progression of malignant tumors

Investigator(s):

Guan XY

Department:

Clinical Oncology

Source(s) of Funding:

Matching Fund for National Key Basic Research Development Scheme (973 Projects)

Start Date:

03/2002

 

Abstract:

To identify recurrent genomic alterations in 30 primary adenocarcinomas of lung and carcinomas using CGH technology; to establish gene expression profiles for lung cancer using cDNA microarray technique; to establish 10 pairs of xenografts of primary and their matched metastatic lung cancer by transplanting tumor cells into nude mice; to study the differences between primary and metastasis lung cancer with mentioned xenografts.

 

Project Title:

Identification of the mechanism of hepatitis B virus (HBV) integration in the development of hepatocellular carcinoma (HCC)

Investigator(s):

Guan XY

Department:

Clinical Oncology

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

01/2003

 

Abstract:

Although the integration of HBV has been associated with the development of HCC, the molecular mehanism remains unclear. It is believed that HBV and host factors (e.g. inflammatory/genetic factors) may contribute together to the process of HCC development. Although the association of HBV and HCC development has been widely studied, only a limited number of integrated HBV have been completely analyzed. Therefore, additional studies with more cases are needed to understand roles of HBV integrants involved in the HCC development. In order to obtain additional insight into the correlation of HBV integration and HCC development, integrated HBV in 10-20 HCC cases will be isolated and characterized by sequencing analysis. findings in this project may greatly facilitate the early diagnosis and prevention of HCC.

 

Project Title:

Characterization of oncogenic role of SEI-1 in the development of ovarian cancer

Investigator(s):

Guan XY

Department:

Clinical Oncology

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

02/2004

 

Abstract:

To study the tumorigenisity of SEI-1 using both in vitro and in vivo approaches; to define the clinical and pathological significance of the amplification of SEI-1 in ovarian cancer.

 

Project Title:

Characterization of roles of a novel oncogene ALC-1 in the development of hepatocellular carcinoma

Investigator(s):

Guan XY, Huang J

Department:

Clinical Oncology

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

10/2004

 

Abstract:

To confirm the tumorigenic role of ALC-1; to investigate the biochemical properties of ALC-1; to study the functions of ALC-1 in vivo by the generation and characterization of transgenic mice overexpressing the ALC-1 gene; to define the clinical and pathological significance of the amplification of ALC-1 in HCC using high-throughput tissue microarray.

 

Project Title:

Oncogeneic role of hepatitis B Virus (HBV) X gene in the development of hepatocellular carcinoma

Investigator(s):

Guan XY, Sham JST

Department:

Clinical Oncology

Source(s) of Funding:

Research Fund for the Control of Infectious Diseases - Full Grants

Start Date:

01/2005

 

Abstract:

To investigate three aspect: 1) characterization of biological role of full-length X and truncated HBx in cell proliferation and apoptosis; 2) identification and characterization of genes regulated by full-length X and truncated HBx using cDNA microarray; 3) construction of an HCC tissue microarray (TMA) with HBV-positive and HBV-negative HCC cases, and application of the TMA in the characterization of candidate genes correlated with HCC carcinogenesis.

 

Project Title:

Characterization of Tumor Suppressing Role of Tyrosine Aminotransferase in HCC

Investigator(s):

Guan XY

Department:

Clinical Oncology

Source(s) of Funding:

Small Project Funding

Start Date:

09/2005

 

Abstract:

Hepatocellular carcinoma (HCC) is one of the most common cancers in the world, especially in Asia including China, and its prognosis has been very poor. It is believed that the pathogenesis of HCC is a long-term process that involves multiple genetic alterations. Deletion of 16q is one of the most frequent chromosomal alterations in primary HCC, as observed in studies using loss of heterozygosity (LOH) and comparative genomic hybridization (CGH). In our previous CGH study, the loss of 16q was observed at a strikingly high rate of 70% in 50 primary HCC cases and this deletion may be an early event in the pathogenesis of HCC. These results strongly suggest that 16q may harbor one or more tumor suppressor genes. Recently, a candidate tumor suppressor gene, Tyrosine aminotransferase (TAT), at 16q22.1 was isolated by cDNA subtraction. Our preliminary work showed that absence and marked reduction expression of TAT was frequently observed in HCC. In addition, homo-deletion of TAT gene was detected in 2/24 HCC cases. TAT encodes the enzyme tyrosine aminotransferase which controls the rate-limiting step for tyrosine catabolism. Many studies have demonstrated that defects in tyrosine catabolism are associated with liver cirrhosis and HCC development. These results suggest that TAT is a candidate tumor suppressor gene and may play an important role in the pathogenesis of HCC. The key objective of this proposal is to investigate the tumor suppressing function of TAT and its role in HCC development. Objectives 1) To investigation of the loss of DNA copy-number in TAT region at 16q22.1 in primary HCC cases. Deletion of DNA copy-number will be studied by real-time PCR. 2) To study TAT expression level in primary HCC cases. TAT expression level in primary HCCs will be compared with their matched non-tumor liver tissues by Northern blot analysis. 3) Mutation analysis of TAT gene and characterization of methylation status at promoter region of TAT gene.

 

Project Title:

Establishment of a High-Throughput Prenatal Diagnostic System for the Detection of Genetic Disorders

Investigator(s):

Guan XY

Department:

Clinical Oncology

Source(s) of Funding:

Seed Funding Programme for Applied Research

Start Date:

10/2006

 

Abstract:

Porpose of the proposed project: Around 3-5% new born babies suffer from genetic disorders in the world and de novo chromosomal change (both numeric and structural changes) is the leading cause of genetic disorders such as Down syndrome. In addition, chromosome abnormality accounted for up to 69.4% spontaneous abortions (Ohno et al., 1991). Therefore, detection of chromosomal changes is one of the key issues addressed in prenatal diagnosis. Currently, several approaches including karyotyping, fluorescence in situ hybridization (FISH) and comparative genomic hybridization (CGH) are frequently used to detect de novo chromosomal alterations in clinical laboratory. Karyotyping is the most frequently used method in prenatal diagnosis which can detect almost all numeric and most structural chromosomal changes. Our laboratory has been working on karyotyping analysis in solid tumors for long time. Karyotyping analysis can provide a whole picture of chromosome status. However, the resolution of karyotyping is very low which can not effectively detect microdeletion less than 10 mega-base pairs. In addition, karyotyping analysis can be only used to analyze mitotic active cells and short-term cell culture is needed. FISH technology was developed in the late 1980s (Pinkel et al., 1986) and it is widely used to detect microdeletions associated with specific diseases, to characterize chromosome rearrangements and marker chromosomes, and to identify aneuploidies in prenatal diagnosis. Previously, we have developed whole chromosome painting probes (Guan et al., 1994), chromosome arm painting probes (Guan et al., 1996) and terminal band-specific painting probes for prenatal diagnosis (Hu et al., 2004). One advantage of FISH is that it can detect chromosomal changes in both metaphase chromosomes and interphase nuclei. For each FISH reaction, 2-3 probes are usually used. Therefore, it is difficult to select probes to study unknown chromosome rearrangements. In addition, the expensiveness and limited types of FISH probes also confine the application of FISH technology. CGH was developed to analyze the entire genome for regional variations of DNA copy number in a single experiment (Kallioniemi et al., 1992). CGH do not need the preparation of metaphase of each sample and it has been widely used in cancer research to find the recurrent genetic alterations in a given cancer (Guan et al., 2000). CGH has also been applied to detect chromosome abnormalities in aborted samples (Tan YQ, et al., 2004). One limitation of CGH is that it can only detect DNA copy number change, but not balanced translocation (one of the most frequent de novo chromosomal changes). Another limitation is the resolution of CGH. Using standard procedures, the detectable size of DNA copy-number change (gain or loss) is about 10Mb. Furthermore, all above three techniques are manual manipulated and can not be automated. Thus, the need for a method for automated screening of chromosomal abnormalities is of utmost importance. Recently, we have used inter-Alu PCR products to generate an Array-CGH platform for cancer research. The array chip contains 600 DNA samples derived from BAC clones of chromosomes 3, 5p, 13, 16q, and 19. This Array-CGH has been applied to study DNA copy-number change in 20 primary lung cancer cases and 50 primary hepatocellular carcinoma (HCC) cases. The results showed that this novel Array-CGH technology is very reliable and several frequently deleted and amplified regions on these chromosomes have been identified. In this proposal, we intend to combine our unique expertise (inter-Alu PCR) to develop a high-throughput Array-CGH chip for the detection of numeric and structural chromosome changes in prenatal diagnosis. Our Array-CGH chip will be composed of inter-Alu PCR amplified DNA from 400 bacterial artificial chromosome (BAC) clones. These BAC clones cover all sub-telomere regions and most frequently deleted regions in prenatal disorders. Objectives: 1. Generation of an Array-CGH chip using DNA products amplified by inter-Alu PCR from 400 BAC clones. 2. Validation of this Array-CGH chip by cell lines and clinical samples. Reference: Guan X-Y, Meltzer PS, Trent JM. (1994) Rapid construction of whole chromosome painting probes by chromosome microdissection. Genomics 22:101-107. Guan X-Y, Zhang HE, Bitter M, Jiang Y, Meltzer PS, Trent JM. (1996) Chromosome arm painting probes. Nature Genet 12:10-11. Guan X-Y, Fang Y, Sham JST, Kwong DLW, Zhang Y, Liang Q, Li H, Zhou H, Trent JM. (2000) Recurrent chromosome alterations in hepatocellular carcinoma detected by comparative genomic hybridization. Genes Chromosomes Cancer 29:110-116. Hu L, Sham JST, J, Tjia WM, Tan YQ, Lu GX, Guan X-Y. (2004) Generation of a complete set of human telomeric-band painting probes by chromosome microdissection. Genomics 83:298-302. Kallioniemi A, Kallioniemi OP, Sudar D, Rutovitz D, Gray JW, Waldman F, Pinkel D. (1992) Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors. Science 258:818-821. Ohno M, Maeda T, Matsunobu A. (1991) A cytogenetic study of spontaneous abortions with direct analysis of chorionic villi. Obstet Gynecol 77:394-398. Pinkel D, Straume T, Gray JW. (1986) Cytogenetic analysis using quantitative, high-sensitivity, fluorescence hybridization. Proc Natl Acad Sci USA 83:2934-2938. Tan YQ, Hu L, Lin G, Sham JS, Gong F, Guan XY, Lu G. (2004) Genetic changes in human fetuses from spontaneous abortion after in vitro fertilization detected by comparative genomic hybridization. Biol Reprod 70:495-499.

 

List of Research Outputs

 

Cheung C.M., Tang J.C.O., Lee P.Y., Hu L., Guan X.Y., Srivastava G., Wong J., Luk J.M.C. and Law S.Y.K., Establishment and characterization of a new xenograft-derived human esophageal squamous cell carcinoma cell line HKESC-4 of chinese origin, 11th Research Postgraduate Symposium (11th RPS), The University of Hong Kong Li Ka Shing Faculty of Medicine, Hong Kong, 7 December. 2006.

 

Lee K.W., Poon R.T.P., Yuen P.W., Man K., Yang Z., Guan X.Y. and Fan S.T., Rac activation is associated with hepatocellular carcinoma metastasis by up-regulation of vascular endothelial growth factor expression, Clinical Cancer Research. 2006, 12(17): 5082-5089.

 

Lee K.W., Poon R.T.P., Yuen P.W., Ling M.T., Wang X., Wong Y.C., Guan X.Y., Man K., Tang Z.Y. and Fan S.T., Regulation of angiogenesis by Id-1 through hypoxia-inducible factor-1 mediated vascular endothelial growth factor up-regulation in hepatocellular carcinoma, Clinical Cancer Research. 2006, 12(23): 6910-6919.

 

Lee K.W., Poon R.T.P., Yuen P.W., Ling M.T., Kwok W.K., Wang X., Wong Y.C., Guan X.Y., Man K., Chau K.L. and Fan S.T., Twist overexpression correlates with hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition, Clinical Cancer Research. 2006, 12(18): 5369-5376.

 

Lee T.K., Poon R.T.P., Yuen P.W., Ling M.T., Kwok W.K., Wang X.H., Wong Y.C., Guan X.Y., Man K., Chau K.L. and Fan S.T., Clin Cancer Res., Twist overexpression correlates with hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition. 2006, 12: 5369-76.

 

Lee T.K., Poon R.T.P., Yuen P.W., Man K., Yang Z., Guan X.Y. and Fan S.T., Clin Cancer Res, Rac activation is associated with hepatocellular carcinoma metastasis by up-regulation of vascular endothelial growth factor expression. 2006, 12: 5082-9.

 

Lee T.K., Poon R.T.P., Yuen P.W., Ling M.T., Wang X.H., Wong Y.C., Guan X.Y., Man K., Tang Z.Y. and Fan S.T., Clin Cancer Res, Regulation of angiogenesis by Id-1 through hypoxia-inducible factor-1alpha-mediated vascular endothelial growth factor up-regulation in hepatocellular carcinoma. 2006, 12: 6910-9.

 

Luk J.M.C., Yi X., Lee P.Y., Guan X.Y., Lau G. and Fan S.T., Mortalin-2 is an accurate prognostic biomarker for early recurrence of liver carcinoma (Abstract), The 17th Asian Pacific Association for the Study of the Liver Conference, Kyoto, Japan, 27 - 30 March 2007. Hepatology International. 2007, 1(1): 68.

 

Lung H.L., Cheung A.K.L., Xie D., Cheng Y., Kwong F.M., Murakami Y., Guan X.Y., Sham J.S.T., Chua D.T.T., Protopopov A.I., Zabarovsky E.R., Tsao G.S.W., Stanbridge E.J. and Lung M.L., TSLC1 is a tumor suppressor gene associated with metastasis in nasopharyngeal carcinoma, Cancer Research. 2006, 66(19): 9385-9392.

 

Ma S.K.Y., Chan K.W., Ng I.O.L., Zheng B. and Guan X.Y., Identification and characterization of CD133+ hepatocellular carcinoma cells as cancer stem/progenitor cells, The 5th International Society for Stem Cell Research, June 2007, Cairns, Australia. 2007.

 

Ma S.K.Y., Chan K.W. and Guan X.Y., Identification and characterization of tumorigenic liver cancer stem cells, Oral Presentation in the Young Investigator Award Session, The 13th Hong Kong International Cancer Congress, November 2006, Hong Kong. 2006.

 

Ma S.K.Y., Chan K.W., Hu L., Lee K.W., Ng I.O.L., Wo Y.H., Zheng B. and Guan X.Y., Identification and characterization of tumorigenic liver cancer stem cells, Proceedings of the Annual Meeting of American Association for Cancer Research, Los Angeles, USA, April. 2007.

 

Ma S.K.Y., Chan K.W. and Guan X.Y., Identification and characterization of tumorigenic liver cancer stem cells, The 11th Research Postgraduate Symposium, The University of Hong Kong, December 2006, Hong Kong. 2006.

 

Ma S.K.Y., Chan K.W., Hu L., Lee K.W., Wo Y.H., Ng I.O.L., Zheng B. and Guan X.Y., Identification and characterization of tumorigenic liver cancer stem/progenitor cells, Gastroenterology. 2007, 132(7): 2542-2556.

 

Ma S.K.Y., Guan X.Y., Beh S.L., Wong K.Y., Chan Y.P., Yuen H.F., Vielkind J. and Chan K.W., The significance of LMO2 expression in the progression of prostate cancer, The Journal of Pathology. 2006, 211(3): 278-85.

 

Tai A.L., Mak W., Ng P.K., Chua D.T., Ng M.Y., Fu L., Chu K.K., Fang Y., Song Y., Chen M., Zhang M., Sham P.C. and Guan X.Y., High-throughput Loss-Heterozygosity Study of Chromosome 3p in Lung Cancer Using Single-Nucleotide Polymorphism Markers., Cancer Res. 2006, 66(8): 4133-8.

 

Tjia W.M., Hu L., Zhang M. and Guan X.Y., Characterization of rearrangements involving 4q, 13q and 16q in hepatocellular carcinoma cell lines using region-specific multiplex-FISH probes. , Cancer Letter. 2007, 250: 92-99.

 

Wang L.D., Qin Y., Fan Z., Kwong D.L.W., Guan X.Y., Tsao G.S.W., Sham J., Li J.L. and Feng X.S., Comparative genomic hybridization: comparison between esophageal squamous cell carcinoma and gastric cardia adenocarcinoma from a high-incidence area for both cancers in Henan, northern China., Diseases of Esophagus. 2006, 19: 459-467.

 

Xu F.P., Xie D., Wen J.M., Wu H.X., Liu Y.D., Bi J., Lv Z.L., Zeng Y.X. and Guan X.Y., SRC-3/AIB1 protein and gene amplification levels in human esophageal squamous cell carcinomas. , Cancer Letter. 2007, 245: 69-74.

 

Zhang Z., Xie D., Li X., Wong Y.C., Xin D., Guan X.Y., Chua C.W., Leung S.C., Na Y. and Wang X., Significance of TWIST expression and its association with E-cadherin in bladder cancer., Human Pathology. 2007, 38: 598-606.

 

Researcher : Hu L



List of Research Outputs

 

Cheung C.M., Tang J.C.O., Lee P.Y., Hu L., Guan X.Y., Srivastava G., Wong J., Luk J.M.C. and Law S.Y.K., Establishment and characterization of a new xenograft-derived human esophageal squamous cell carcinoma cell line HKESC-4 of chinese origin, 11th Research Postgraduate Symposium (11th RPS), The University of Hong Kong Li Ka Shing Faculty of Medicine, Hong Kong, 7 December. 2006.

 

Ma S.K.Y., Chan K.W., Hu L., Lee K.W., Ng I.O.L., Wo Y.H., Zheng B. and Guan X.Y., Identification and characterization of tumorigenic liver cancer stem cells, Proceedings of the Annual Meeting of American Association for Cancer Research, Los Angeles, USA, April. 2007.

 

Ma S.K.Y., Chan K.W., Hu L., Lee K.W., Wo Y.H., Ng I.O.L., Zheng B. and Guan X.Y., Identification and characterization of tumorigenic liver cancer stem/progenitor cells, Gastroenterology. 2007, 132(7): 2542-2556.

 

Tjia W.M., Hu L., Zhang M. and Guan X.Y., Characterization of rearrangements involving 4q, 13q and 16q in hepatocellular carcinoma cell lines using region-specific multiplex-FISH probes. , Cancer Letter. 2007, 250: 92-99.

 

Researcher : Kwong DLW



Project Title:

A pilot study for radiosensitization with COX-2 inhibitor for nasopharyngeal carcinoma

Investigator(s):

Kwong DLW, Nicholls JM

Department:

Clinical Oncology

Source(s) of Funding:

Small Project Funding

Start Date:

12/2005

Completion Date:

11/2006

 

Abstract:

1. To assess feasibility and toxicity of COX-2 inhibition in addition to radiotherapy/chemoradiation for nasopharyngeal carcinoma. 2. To assess molecular response in tumor to COX-2 inhibition by biopsies taken during treatment. Markers for COX-2, angiogenesis and proliferation will be studied by immunochemistry and RNA microarray.

 

List of Research Outputs

 

Baujat B., Audry H., Bourhis J., Chan A.T., Onat H., Chua D.T.T., Kwong D.L.W., Al-Saraff M., Chi K., Hareyama M., Leung S.F., Thephamongkhol K. and Pignon J., Chemotherapy as an adjunct to radiotherapy in locally advanced nasopharyngeal carcinoma., Cochrane Database Systemic Review. 2006, CD004329.

 

Chiang A.K.S., Yuan X., Chan G.C.F., Kwong D.L.W., Chan T. and Ha S.Y., Treatment Outcome of Rhabdomyosarcoma in Hong Kong Chinese Children, 13th Hong Kong International Cancer Congress, 3rd Annual Meeting Centre for Cancer Research, HKU, 15-17 November 2006.

 

Ho D.W.Y., Yang Z., Wong B.Y.H., Kwong D.L.W., Sham J.S.T., Wei W.I. and Yuen P.W., Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry serum protein profiling to identify nasopharyngeal carcinoma, Cancer. 2006, 107(1): 99-107.

 

Ho W.K., Yang Z., Wong B.Y., Kwong D.L.W., Sham J.S.T., Wei W.I. and Yuen P.W., Cancer, Surface-enhanced laser desorption / ionization time-of-flight mass spectrometry serum protein profiling to identify nasopharyngeal carcinoma. 2006, 107: 99-107.

 

Law S.Y.K., Kwong D.L.W., Wong K.H., Kwok K.F. and Wong J., The effects of neoadjuvant chemoradiation on pTNM staging and its prognostic significance in esophageal cancer, Journal of Gastrointestinal Surgery. 2006, 10(9): 1301-1311.

 

Li J., Kwong D.L.W. and Chan G.C.F., The effects of various irradiation doses on the growth and differentiation of marrow deerived human mesenchymal stromal cells, The 11th Congress of the Asia Pacific Bone Marrow Transplantation (oral presentation), Nagoya, Japan, 27-29 October 2006.

 

Li J., Kwong D.L.W. and Chan G.C.F., The effects of various irradiation doses on the growth and differentiation of marrow-derived human mesenchymal stromal cells, Pediatric Transplantation. Blackwell Munksgaard, 2007, 11: 379-387.

 

McMillan A.S., Pow E.H.N., Kwong D.L.W., Wong M.C.M., Sham J.S.T., Leung L.H.T. and Leung W.K., Preservation of quality of life after intensity-modulated radiotherapy for early-stage nasopharyngeal carcinoma: Results of a prospective longitudinal study, Head & Neck. 2006, 28: 712-722.

 

Nicholls J.M., Chan M.C.W., Chan W.Y., Wong H.K., Kwong D.L.W., Wong M.P., Chui W.H., Poon L.L.M., Tsao G.S.W., Guan Y. and Peiris J.S.M., Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract, Nature Medicine. 2007, 13(2): 147-149.

 

Pow E.H.N., Kwong D.L.W., McMillan A.S., Wong M.C.M., Sham J.S.T., Leung L.H.T. and Leung W.K., Xerostomia and quality of life after intensity-modulated radiotherapy vs. conventional radiotherapy for early-stage nasopharyngeal carcinoma: Initial report on a randomized control clinical trial., International Journal of Radiation Oncology, Biology, Physics. 2006, 66: 981-991.

 

Qiu D., Kwong D.L.W., Chan G.C.F., Leung L.H.T. and Khong P.L., Diffusion tensor MR imaging finding of discrepant fractional anisotropy between the frontal and parietal lobes after whole-brain irradiation in childhood medulloblastoma survivors: reflection of regional white matter radiosensitivity? , Internal Journal of Radiation Oncology Biology Physics. 2007, 69: 846-851.

 

Wang L.D., Qin Y., Fan Z., Kwong D.L.W., Guan X.Y., Tsao G.S.W., Sham J., Li J.L. and Feng X.S., Comparative genomic hybridization: comparison between esophageal squamous cell carcinoma and gastric cardia adenocarcinoma from a high-incidence area for both cancers in Henan, northern China., Diseases of Esophagus. 2006, 19: 459-467.

 

Researcher : Lee AWM



List of Research Outputs

 

Lee A.W.M., Tung S.Y., Chan A.T.C., Chappell R., Fu Y.T., Lu T.X., Tan T., Chua D.T.T., O'Sullivan B., Xu L., Pang E.S.Y., Sze W.M., Leung T.W., Kwan W.H., Chan P.T.M., Liu X.F., Tan E.H., Sham J.S.T., Siu L. and Lau W.H., Preliminary results of a prospective randomized study (NPC-9902 Trial) on the therapeutic gain by concurrent chemotherapy and/or accelerated fractionation for locally-advanced nasopharyngeal carcinoma, International Journal of Radiation Oncology Biology Physcis. 2006, 66: 142-151.

 

Teo P.M., Leung S.F., Tung S.Y., Zee B., Sham J.S.T., Lee A.W.M., Lau W.H., Kwan W.H., Leung T.W. and Chua D.T.T., Dose-response relationship of nasopharyngeal carcinoma above conventional tumoricidal level: a study by the Hong Kong nasopharyngeal carcinoma study group (HKNPCSG), Radiotherapy Oncology. 2006, 79: 227-33.

 

Researcher : Leung TW



List of Research Outputs

 

Lee A.W.M., Tung S.Y., Chan A.T.C., Chappell R., Fu Y.T., Lu T.X., Tan T., Chua D.T.T., O'Sullivan B., Xu L., Pang E.S.Y., Sze W.M., Leung T.W., Kwan W.H., Chan P.T.M., Liu X.F., Tan E.H., Sham J.S.T., Siu L. and Lau W.H., Preliminary results of a prospective randomized study (NPC-9902 Trial) on the therapeutic gain by concurrent chemotherapy and/or accelerated fractionation for locally-advanced nasopharyngeal carcinoma, International Journal of Radiation Oncology Biology Physcis. 2006, 66: 142-151.

 

Teo P.M., Leung S.F., Tung S.Y., Zee B., Sham J.S.T., Lee A.W.M., Lau W.H., Kwan W.H., Leung T.W. and Chua D.T.T., Dose-response relationship of nasopharyngeal carcinoma above conventional tumoricidal level: a study by the Hong Kong nasopharyngeal carcinoma study group (HKNPCSG), Radiotherapy Oncology. 2006, 79: 227-33.

 

Researcher : Qin Y



List of Research Outputs

 

Wang L.D., Qin Y., Fan Z., Kwong D.L.W., Guan X.Y., Tsao G.S.W., Sham J., Li J.L. and Feng X.S., Comparative genomic hybridization: comparison between esophageal squamous cell carcinoma and gastric cardia adenocarcinoma from a high-incidence area for both cancers in Henan, northern China., Diseases of Esophagus. 2006, 19: 459-467.

 

Researcher : Sham JST



List of Research Outputs

 

Chan C.L.W., Ho T.H., Lee P.W.H., Cheng J.Y.Y., Leung P.P.Y., Foo W., Chow L.W.H., Sham J.S.T. and Spiegel D., A Randomized Controlled Trial of Psychosocial Interventions Using the Psychophysiological Framework for Chinese Breast Cancer Patients, In: James R Zabora, Journal of Psychosocial Oncology. The Haworth Medical Press, 2006, 24(1): 3-26.

 

Chua D.T.T., Ma J., Sham J.S.T., Mai H.Q., Choy D.T.K., Hong M.H., Lu T.X., Au G.K.H. and Min H.Q., Improvement of survival after addition of induction chemotherapy to radiotherapy in patients with early-stage nasopharyngeal carcinoma: Subgroup analysis of two Phase III trials. , International Journal of Radiation Oncology Biology Physcis. 2006, 65(5): 1300-1306.

 

Chua D.T.T., Sham J.S.T., Hung K.N., Leung H.T. and Au G.K.H., Predictive factors of tumor control and survival after radiosurgery of local failures of nasopharyngeal carcinoma., International Journal of Radiation Oncology Biology Physcis. 2006, 66: 1415-1421.

 

Ho D.W.Y., Yang Z., Wong B.Y.H., Kwong D.L.W., Sham J.S.T., Wei W.I. and Yuen P.W., Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry serum protein profiling to identify nasopharyngeal carcinoma, Cancer. 2006, 107(1): 99-107.

 

Ho W.K., Yang Z., Wong B.Y., Kwong D.L.W., Sham J.S.T., Wei W.I. and Yuen P.W., Cancer, Surface-enhanced laser desorption / ionization time-of-flight mass spectrometry serum protein profiling to identify nasopharyngeal carcinoma. 2006, 107: 99-107.

 

Ji M.F., Wang D.K., Yu Y.L., Guo Y.Q., Liang J.S., Cheng W.M., Zong Y.S., Chan K.H., Ng S.P., Wei W.I., Chua D.T.T., Sham J.S.T. and Ng M.H., Sustained elevation of Epstein-Barr virus antibody levels preceding clinical onset of nasopharyngeal carcinoma., British Journal of Cancer. 2007, 96: 623-630.

 

Lee A.W.M., Tung S.Y., Chan A.T.C., Chappell R., Fu Y.T., Lu T.X., Tan T., Chua D.T.T., O'Sullivan B., Xu L., Pang E.S.Y., Sze W.M., Leung T.W., Kwan W.H., Chan P.T.M., Liu X.F., Tan E.H., Sham J.S.T., Siu L. and Lau W.H., Preliminary results of a prospective randomized study (NPC-9902 Trial) on the therapeutic gain by concurrent chemotherapy and/or accelerated fractionation for locally-advanced nasopharyngeal carcinoma, International Journal of Radiation Oncology Biology Physcis. 2006, 66: 142-151.

 

Lee D.C.W., Chua D.T.T., Sham J.S.T., Wei W.I. and Lau A.S.Y., Differential induction of matrix metallo-proteinase 3 by Epstein-Barr virus latent membrane protein 1, Organisation for Oncology and Translational Research 3rd Annual Conference, Hong Kong Academy of Medicine (Neoadjuvant & Molecular Therapy in Cancer), 22-23 September 2006.

 

Lee D.C.W., Chua D.T.T., Sham J.S.T. and Lau A.S.Y., Epstein-Barr virus latent membrane protein 1 enhances matrix metalloproteinase 3 induction in human fibroblast, The 6th International Cytokine Conference 2006 (European Cytokine Network, Supplement Aug 2006, Vol 17 - as official journal of Cytokine 2006-Vienna), Vienna, Austria, 27-31 August 2006. 17: 14-06/P.

 

Lee D.C.W., Chua D.T.T., Sham J.S.T. and Lau A.S.Y., Expression of Matrix Metallo-proteinase 3 by Epstein-Barr Virus Latent Membrane Protein 1, 6th International Cytokine Conference Proceedings, Medimond International Proceedings, Bologna, Italy, 27-31 August 2006. 101-104.

 

Lung H.L., Cheung A.K.L., Xie D., Cheng Y., Kwong F.M., Murakami Y., Guan X.Y., Sham J.S.T., Chua D.T.T., Protopopov A.I., Zabarovsky E.R., Tsao G.S.W., Stanbridge E.J. and Lung M.L., TSLC1 is a tumor suppressor gene associated with metastasis in nasopharyngeal carcinoma, Cancer Research. 2006, 66(19): 9385-9392.

 

McMillan A.S., Pow E.H.N., Kwong D.L.W., Wong M.C.M., Sham J.S.T., Leung L.H.T. and Leung W.K., Preservation of quality of life after intensity-modulated radiotherapy for early-stage nasopharyngeal carcinoma: Results of a prospective longitudinal study, Head & Neck. 2006, 28: 712-722.

 

Pow E.H.N., Kwong D.L.W., McMillan A.S., Wong M.C.M., Sham J.S.T., Leung L.H.T. and Leung W.K., Xerostomia and quality of life after intensity-modulated radiotherapy vs. conventional radiotherapy for early-stage nasopharyngeal carcinoma: Initial report on a randomized control clinical trial., International Journal of Radiation Oncology, Biology, Physics. 2006, 66: 981-991.

 

Teo P.M., Leung S.F., Tung S.Y., Zee B., Sham J.S.T., Lee A.W.M., Lau W.H., Kwan W.H., Leung T.W. and Chua D.T.T., Dose-response relationship of nasopharyngeal carcinoma above conventional tumoricidal level: a study by the Hong Kong nasopharyngeal carcinoma study group (HKNPCSG), Radiotherapy Oncology. 2006, 79: 227-33.

 

Yau W.L., Lung H.L., Zabarovsky E.R., Lerman M.I., Sham J.S.T., Chua D.T.T., Tsao G.S.W., Stanbridge E.J. and Lung M.L., Functional studies of the chromosome 3p21.3 candidate tumor suppressor gene BLU/ZMYND10 in nasopharyngeal carcinoma, International Journal of Cancer. 2006, 119: 2821-2826.

 

Researcher : Sze WM



List of Research Outputs

 

Lee A.W.M., Tung S.Y., Chan A.T.C., Chappell R., Fu Y.T., Lu T.X., Tan T., Chua D.T.T., O'Sullivan B., Xu L., Pang E.S.Y., Sze W.M., Leung T.W., Kwan W.H., Chan P.T.M., Liu X.F., Tan E.H., Sham J.S.T., Siu L. and Lau W.H., Preliminary results of a prospective randomized study (NPC-9902 Trial) on the therapeutic gain by concurrent chemotherapy and/or accelerated fractionation for locally-advanced nasopharyngeal carcinoma, International Journal of Radiation Oncology Biology Physcis. 2006, 66: 142-151.

 

Researcher : Tjia WM



List of Research Outputs

 

Tjia W.M., Hu L., Zhang M. and Guan X.Y., Characterization of rearrangements involving 4q, 13q and 16q in hepatocellular carcinoma cell lines using region-specific multiplex-FISH probes. , Cancer Letter. 2007, 250: 92-99.

 

Researcher : Xie D



List of Research Outputs

 

Lung H.L., Cheung A.K.L., Xie D., Cheng Y., Kwong F.M., Murakami Y., Guan X.Y., Sham J.S.T., Chua D.T.T., Protopopov A.I., Zabarovsky E.R., Tsao G.S.W., Stanbridge E.J. and Lung M.L., TSLC1 is a tumor suppressor gene associated with metastasis in nasopharyngeal carcinoma, Cancer Research. 2006, 66(19): 9385-9392.

 

Xu F.P., Xie D., Wen J.M., Wu H.X., Liu Y.D., Bi J., Lv Z.L., Zeng Y.X. and Guan X.Y., SRC-3/AIB1 protein and gene amplification levels in human esophageal squamous cell carcinomas. , Cancer Letter. 2007, 245: 69-74.

 

Zhang Z., Xie D., Li X., Wong Y.C., Xin D., Guan X.Y., Chua C.W., Leung S.C., Na Y. and Wang X., Significance of TWIST expression and its association with E-cadherin in bladder cancer., Human Pathology. 2007, 38: 598-606.

 

Researcher : Zhang M



List of Research Outputs

 

Tjia W.M., Hu L., Zhang M. and Guan X.Y., Characterization of rearrangements involving 4q, 13q and 16q in hepatocellular carcinoma cell lines using region-specific multiplex-FISH probes. , Cancer Letter. 2007, 250: 92-99.



-- End of Listing --