DEPT OF CLINICAL ONCOLOGY
Researcher
: Au GKH |
List of Research Outputs |
Chua
D.T.T., Ma J., Sham J.S.T., |
Chua D.T.T., Sham J.S.T., Hung K.N., Leung H.T. and Au G.K.H., Predictive factors of tumor control and survival after radiosurgery of local failures of nasopharyngeal carcinoma., International Journal of Radiation Oncology Biology Physcis. 2006, 66: 1415-1421. |
Researcher
: Bi J |
List of Research Outputs |
Xu F.P., Xie D., Wen J.M., Wu H.X., Liu Y.D., Bi J., Lv Z.L., Zeng Y.X. and Guan X.Y., SRC-3/AIB1 protein and gene amplification levels in human esophageal squamous cell carcinomas. , Cancer Letter. 2007, 245: 69-74. |
Researcher
: Choy DTK |
List of Research Outputs |
Chua
D.T.T., Ma J., Sham J.S.T., |
Researcher
: Chua DTT |
List of Research Outputs |
Baujat B., Audry H., Bourhis J., Chan A.T., Onat H., Chua D.T.T., Kwong D.L.W., Al-Saraff M., Chi K., Hareyama M., Leung S.F., Thephamongkhol K. and Pignon J., Chemotherapy as an adjunct to radiotherapy in locally advanced nasopharyngeal carcinoma., Cochrane Database Systemic Review. 2006, CD004329. |
Chua D.T.T., A Single-center Experience of Capecitabine as Palliative Chemotherapy in Nasopharyngeal Carcinoma. Update on Nasopharyngeal Carcinoma, Joint Annual Scientific Meeting of The Hong Kong Nasopharyngeal Cancer Study Group and The Hong Kong Head and Neck Society. 2006. |
Chua D.T.T., Editor, Clinical Medicine: Oncology. 2007. |
Chua
D.T.T., Ma J., Sham J.S.T., |
Chua D.T.T., Improving Management of Nasopharyngeal Carcinoma., Fifth Roche Asia Oncology Forum. 2006. |
Chua
D.T.T., Late Complications Following
Radiotherapy for Intraoral Cancers., First World Congress of |
Chua D.T.T., Sham J.S.T., Hung K.N., Leung H.T. and Au G.K.H., Predictive factors of tumor control and survival after radiosurgery of local failures of nasopharyngeal carcinoma., International Journal of Radiation Oncology Biology Physcis. 2006, 66: 1415-1421. |
Chua D.T.T., Recent Advances in the Treatment of Nasopharyngeal Carcinoma, Eighth National Congress on Nasopharyngeal Carcinoma. 2007. |
Chua D.T.T., The Role of Radiotherapy in the Management of Head and Neck Cancer., Cancer Imaging Conference 2007. 2007. |
Chua D.T.T., Treatment Approaches for Locally Recurrent Nasopharyngeal Carcinoma., 11th Annual Scientific Symposium of the Hong Kong Cancer Institute. 2006. |
Ji M.F., Wang D.K., Yu Y.L., Guo Y.Q., Liang J.S., Cheng W.M., Zong Y.S., Chan K.H., Ng S.P., Wei W.I., Chua D.T.T., Sham J.S.T. and Ng M.H., Sustained elevation of Epstein-Barr virus antibody levels preceding clinical onset of nasopharyngeal carcinoma., British Journal of Cancer. 2007, 96: 623-630. |
Khoo
U.S., Liu W., Long J.R., Yip
S.P., Cheung A.N.Y., Chua D.T.T., Chan S.Y., Ngan H.Y.S., Zheng W. and Chan Y.K., The functional |
Lee A.W.M., Tung S.Y., Chan A.T.C., Chappell R., Fu Y.T., Lu T.X., Tan T., Chua D.T.T., O'Sullivan B., Xu L., Pang E.S.Y., Sze W.M., Leung T.W., Kwan W.H., Chan P.T.M., Liu X.F., Tan E.H., Sham J.S.T., Siu L. and Lau W.H., Preliminary results of a prospective randomized study (NPC-9902 Trial) on the therapeutic gain by concurrent chemotherapy and/or accelerated fractionation for locally-advanced nasopharyngeal carcinoma, International Journal of Radiation Oncology Biology Physcis. 2006, 66: 142-151. |
Lee D.C.W., Chua D.T.T., Sham J.S.T., Wei W.I. and Lau A.S.Y., Differential induction of matrix metallo-proteinase 3 by Epstein-Barr virus latent membrane protein 1, Organisation for Oncology and Translational Research 3rd Annual Conference, Hong Kong Academy of Medicine (Neoadjuvant & Molecular Therapy in Cancer), 22-23 September 2006. |
Lee D.C.W., Chua D.T.T., Sham J.S.T. and Lau A.S.Y., Epstein-Barr virus latent membrane protein 1 enhances matrix metalloproteinase 3 induction in human fibroblast, The 6th International Cytokine Conference 2006 (European Cytokine Network, Supplement Aug 2006, Vol 17 - as official journal of Cytokine 2006-Vienna), Vienna, Austria, 27-31 August 2006. 17: 14-06/P. |
Lee D.C.W., Chua D.T.T., Sham J.S.T. and Lau A.S.Y., Expression of Matrix Metallo-proteinase 3 by Epstein-Barr Virus Latent Membrane Protein 1, 6th International Cytokine Conference Proceedings, Medimond International Proceedings, Bologna, Italy, 27-31 August 2006. 101-104. |
Lung H.L., Cheung A.K.L., Xie D., Cheng Y., Kwong F.M., Murakami Y., Guan X.Y., Sham J.S.T., Chua D.T.T., Protopopov A.I., Zabarovsky E.R., Tsao G.S.W., Stanbridge E.J. and Lung M.L., TSLC1 is a tumor suppressor gene associated with metastasis in nasopharyngeal carcinoma, Cancer Research. 2006, 66(19): 9385-9392. |
Teo P.M., Leung S.F., Tung S.Y., Zee B., Sham J.S.T., Lee A.W.M., Lau W.H., Kwan W.H., Leung T.W. and Chua D.T.T., Dose-response relationship of nasopharyngeal carcinoma above conventional tumoricidal level: a study by the Hong Kong nasopharyngeal carcinoma study group (HKNPCSG), Radiotherapy Oncology. 2006, 79: 227-33. |
Yau W.L., Lung H.L., Zabarovsky E.R.,
Lerman M.I., Sham J.S.T., Chua D.T.T., Tsao G.S.W., Stanbridge E.J. and Lung
M.L., Functional studies of the chromosome 3p21.3 candidate tumor suppressor
gene BLU/ZMYND |
Researcher
: Fan Z |
List of Research Outputs |
Wang L.D., Qin Y., Fan Z., Kwong D.L.W., Guan X.Y., Tsao G.S.W., Sham J., Li J.L. and Feng X.S., Comparative genomic hybridization: comparison between esophageal squamous cell carcinoma and gastric cardia adenocarcinoma from a high-incidence area for both cancers in Henan, northern China., Diseases of Esophagus. 2006, 19: 459-467. |
Researcher
: Guan XY |
Project Title: |
Isolation of genes related to the pathogenesis of hepatocellular carcinoma and nasopharyngeal carcinoma: identification of the association between amplication of oncogenes and cancer prognosis |
Investigator(s): |
Guan XY |
Department: |
Clinical Oncology |
Source(s) of Funding: |
Matching Fund for NSFC Young Researcher Award |
Start Date: |
05/2001 |
Abstract: |
To study isolation of genes related to the pathogenesis of hepatocellular carcinoma and nasopharyngeal carcinoma: identification of the association between amplication of oncogenes and cancer prognosis. |
Project Title: |
Basic research for the mechanisms of development and progression of malignant tumors |
Investigator(s): |
Guan XY |
Department: |
Clinical Oncology |
Source(s) of Funding: |
Matching Fund for National Key Basic Research Development Scheme (973 Projects) |
Start Date: |
03/2002 |
Abstract: |
To identify recurrent genomic alterations in 30 primary adenocarcinomas of lung and carcinomas using CGH technology; to establish gene expression profiles for lung cancer using cDNA microarray technique; to establish 10 pairs of xenografts of primary and their matched metastatic lung cancer by transplanting tumor cells into nude mice; to study the differences between primary and metastasis lung cancer with mentioned xenografts. |
Project Title: |
Identification of the mechanism of hepatitis B virus (HBV) integration in the development of hepatocellular carcinoma (HCC) |
Investigator(s): |
Guan XY |
Department: |
Clinical Oncology |
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
Start Date: |
01/2003 |
Abstract: |
Although the integration of HBV has been associated with the development of HCC, the molecular mehanism remains unclear. It is believed that HBV and host factors (e.g. inflammatory/genetic factors) may contribute together to the process of HCC development. Although the association of HBV and HCC development has been widely studied, only a limited number of integrated HBV have been completely analyzed. Therefore, additional studies with more cases are needed to understand roles of HBV integrants involved in the HCC development. In order to obtain additional insight into the correlation of HBV integration and HCC development, integrated HBV in 10-20 HCC cases will be isolated and characterized by sequencing analysis. findings in this project may greatly facilitate the early diagnosis and prevention of HCC. |
Project Title: |
Characterization
of oncogenic role of SEI |
Investigator(s): |
Guan XY |
Department: |
Clinical Oncology |
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
Start Date: |
02/2004 |
Abstract: |
To study the tumorigenisity of SEI-1
using both in vitro and in vivo approaches; to define the clinical and
pathological significance of the amplification of SEI |
Project Title: |
Characterization
of roles of a novel oncogene ALC |
Investigator(s): |
Guan XY, Huang J |
Department: |
Clinical Oncology |
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
Start Date: |
10/2004 |
Abstract: |
To confirm the tumorigenic role of ALC-1;
to investigate the biochemical properties of ALC-1; to study the functions of
ALC |
Project Title: |
Oncogeneic role of hepatitis B Virus (HBV) X gene in the development of hepatocellular carcinoma |
Investigator(s): |
Guan XY, Sham JST |
Department: |
Clinical Oncology |
Source(s) of Funding: |
Research Fund for the Control of Infectious Diseases - Full Grants |
Start Date: |
01/2005 |
Abstract: |
To investigate three aspect: 1) characterization of biological role of full-length X and truncated HBx in cell proliferation and apoptosis; 2) identification and characterization of genes regulated by full-length X and truncated HBx using cDNA microarray; 3) construction of an HCC tissue microarray (TMA) with HBV-positive and HBV-negative HCC cases, and application of the TMA in the characterization of candidate genes correlated with HCC carcinogenesis. |
Project Title: |
Characterization of Tumor Suppressing Role of Tyrosine Aminotransferase in HCC |
Investigator(s): |
Guan XY |
Department: |
Clinical Oncology |
Source(s) of Funding: |
Small Project Funding |
Start Date: |
09/2005 |
Abstract: |
Hepatocellular carcinoma (HCC) is one of
the most common cancers in the world, especially in Asia including |
Project Title: |
Establishment of a High-Throughput Prenatal Diagnostic System for the Detection of Genetic Disorders |
Investigator(s): |
Guan XY |
Department: |
Clinical Oncology |
Source(s) of Funding: |
Seed Funding Programme for Applied Research |
Start Date: |
10/2006 |
Abstract: |
Porpose of the proposed project: Around
3-5% new born babies suffer from genetic disorders in the world and de novo
chromosomal change (both numeric and structural changes) is the leading cause
of genetic disorders such as Down syndrome. In addition, chromosome
abnormality accounted for up to 69.4% spontaneous abortions (Ohno et al.,
1991). Therefore, detection of chromosomal changes is one of the key issues
addressed in prenatal diagnosis. Currently, several approaches including
karyotyping, fluorescence in situ hybridization (FISH) and comparative
genomic hybridization (CGH) are frequently used to detect de novo chromosomal
alterations in clinical laboratory. Karyotyping is the most frequently used
method in prenatal diagnosis which can detect almost all numeric and most
structural chromosomal changes. Our laboratory has been working on
karyotyping analysis in solid tumors for long time. Karyotyping analysis can
provide a whole picture of chromosome status. However, the resolution of
karyotyping is very low which can not effectively detect microdeletion less
than 10 mega-base pairs. In addition, karyotyping analysis can be only used
to analyze mitotic active cells and short-term cell culture is needed. FISH
technology was developed in the late 1980s (Pinkel et al., 1986) and it is
widely used to detect microdeletions associated with specific diseases, to
characterize chromosome rearrangements and marker chromosomes, and to
identify aneuploidies in prenatal diagnosis. Previously, we have developed
whole chromosome painting probes (Guan et al., 1994), chromosome arm painting
probes (Guan et al., 1996) and terminal band-specific painting probes for
prenatal diagnosis (Hu et al., 2004). One advantage of FISH is that it can
detect chromosomal changes in both metaphase chromosomes and interphase
nuclei. For each FISH reaction, 2-3 probes are usually used. Therefore, it is
difficult to select probes to study unknown chromosome rearrangements. In
addition, the expensiveness and limited types of FISH probes also confine the
application of FISH technology. CGH was developed to analyze the entire
genome for regional variations of DNA copy number in a single experiment
(Kallioniemi et al., 1992). CGH do not need the preparation of metaphase of
each sample and it has been widely used in cancer research to find the
recurrent genetic alterations in a given cancer (Guan et al., 2000). CGH has
also been applied to detect chromosome abnormalities in aborted samples (Tan
YQ, et al., 2004). One limitation of CGH is that it can only detect DNA copy
number change, but not balanced translocation (one of the most frequent de
novo chromosomal changes). Another limitation is the resolution of CGH. Using
standard procedures, the detectable size of DNA copy-number change (gain or
loss) is about 10Mb. Furthermore, all above three techniques are manual
manipulated and can not be automated. Thus, the need for a method for
automated screening of chromosomal abnormalities is of utmost importance.
Recently, we have used inter-Alu PCR products to generate an Array-CGH
platform for cancer research. The array chip contains 600 DNA samples derived
from BAC clones of chromosomes 3, 5p, 13, 16q, and 19. This Array-CGH has
been applied to study DNA copy-number change in 20 primary lung cancer cases
and 50 primary hepatocellular carcinoma (HCC) cases. The results showed that
this novel Array-CGH technology is very reliable and several frequently
deleted and amplified regions on these chromosomes have been identified. In
this proposal, we intend to combine our unique expertise (inter-Alu PCR) to
develop a high-throughput Array-CGH chip for the detection of numeric and
structural chromosome changes in prenatal diagnosis. Our Array-CGH chip will
be composed of inter-Alu PCR amplified DNA from 400 bacterial artificial
chromosome (BAC) clones. These BAC clones cover all sub-telomere regions and
most frequently deleted regions in prenatal disorders. Objectives: 1.
Generation of an Array-CGH chip using DNA products amplified by inter-Alu PCR
from 400 BAC clones. 2. Validation of this Array-CGH chip by cell lines and
clinical samples. Reference: Guan X-Y, Meltzer PS, Trent JM. (1994) Rapid
construction of whole chromosome painting probes by chromosome
microdissection. Genomics 22:101-107. Guan X-Y, Zhang HE, Bitter M, Jiang Y,
Meltzer PS, Trent JM. (1996) Chromosome arm painting probes. Nature Genet
12:10-11. Guan X-Y, Fang Y, Sham JST, Kwong DLW, Zhang Y, Liang Q, Li H, Zhou
H, Trent JM. (2000) Recurrent chromosome alterations in hepatocellular
carcinoma detected by comparative genomic hybridization. Genes Chromosomes
Cancer 29:110-116. Hu L, Sham JST, J, Tjia WM, Tan YQ, Lu GX, Guan X-Y.
(2004) Generation of a complete set of human telomeric-band painting probes
by chromosome microdissection. Genomics 83:298-302. Kallioniemi A,
Kallioniemi OP, Sudar D, Rutovitz D, Gray JW, Waldman F, Pinkel D. (1992)
Comparative genomic hybridization for molecular cytogenetic analysis of solid
tumors. Science 258:818-821. Ohno M, Maeda T, Matsunobu A. (1991) A
cytogenetic study of spontaneous abortions with direct analysis of chorionic
villi. Obstet Gynecol 77:394-398. Pinkel D, Straume T, Gray JW. (1986)
Cytogenetic analysis using quantitative, high-sensitivity, fluorescence
hybridization. Proc Natl Acad Sci |
List of Research Outputs |
Cheung C.M., Tang J.C.O., Lee P.Y., Hu L., Guan X.Y., Srivastava G., Wong J., Luk J.M.C. and Law S.Y.K., Establishment and characterization of a new xenograft-derived human esophageal squamous cell carcinoma cell line HKESC-4 of chinese origin, 11th Research Postgraduate Symposium (11th RPS), The University of Hong Kong Li Ka Shing Faculty of Medicine, Hong Kong, 7 December. 2006. |
Lee K.W., Poon R.T.P., Yuen P.W., Man K., Yang Z., Guan X.Y. and Fan S.T., Rac activation is associated with hepatocellular carcinoma metastasis by up-regulation of vascular endothelial growth factor expression, Clinical Cancer Research. 2006, 12(17): 5082-5089. |
Lee K.W., Poon R.T.P., Yuen P.W., Ling M.T., Wang X., Wong Y.C., Guan X.Y., Man K., Tang Z.Y. and Fan S.T., Regulation of angiogenesis by Id-1 through hypoxia-inducible factor-1 mediated vascular endothelial growth factor up-regulation in hepatocellular carcinoma, Clinical Cancer Research. 2006, 12(23): 6910-6919. |
Lee K.W., Poon R.T.P., Yuen P.W., Ling M.T., Kwok W.K., Wang X., Wong Y.C., Guan X.Y., Man K., Chau K.L. and Fan S.T., Twist overexpression correlates with hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition, Clinical Cancer Research. 2006, 12(18): 5369-5376. |
Lee T.K., Poon R.T.P., Yuen P.W., Ling M.T., Kwok W.K., Wang X.H., Wong Y.C., Guan X.Y., Man K., Chau K.L. and Fan S.T., Clin Cancer Res., Twist overexpression correlates with hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition. 2006, 12: 5369-76. |
Lee T.K., Poon R.T.P., Yuen P.W., Man K., Yang Z., Guan X.Y. and Fan S.T., Clin Cancer Res, Rac activation is associated with hepatocellular carcinoma metastasis by up-regulation of vascular endothelial growth factor expression. 2006, 12: 5082-9. |
Lee T.K., Poon R.T.P., Yuen P.W., Ling M.T., Wang X.H., Wong Y.C., Guan X.Y., Man K., Tang Z.Y. and Fan S.T., Clin Cancer Res, Regulation of angiogenesis by Id-1 through hypoxia-inducible factor-1alpha-mediated vascular endothelial growth factor up-regulation in hepatocellular carcinoma. 2006, 12: 6910-9. |
Luk J.M.C., Yi X., Lee P.Y., Guan X.Y., Lau G. and Fan S.T., Mortalin-2 is an accurate prognostic biomarker for early recurrence of liver carcinoma (Abstract), The 17th Asian Pacific Association for the Study of the Liver Conference, Kyoto, Japan, 27 - 30 March 2007. Hepatology International. 2007, 1(1): 68. |
Lung H.L., Cheung A.K.L., Xie D., Cheng Y., Kwong F.M., Murakami Y., Guan X.Y., Sham J.S.T., Chua D.T.T., Protopopov A.I., Zabarovsky E.R., Tsao G.S.W., Stanbridge E.J. and Lung M.L., TSLC1 is a tumor suppressor gene associated with metastasis in nasopharyngeal carcinoma, Cancer Research. 2006, 66(19): 9385-9392. |
Ma S.K.Y., Chan K.W., Ng I.O.L., Zheng B. and Guan X.Y., Identification and characterization of CD133+ hepatocellular carcinoma cells as cancer stem/progenitor cells, The 5th International Society for Stem Cell Research, June 2007, Cairns, Australia. 2007. |
Ma S.K.Y., Chan K.W. and Guan X.Y., Identification and characterization of tumorigenic liver cancer stem cells, Oral Presentation in the Young Investigator Award Session, The 13th Hong Kong International Cancer Congress, November 2006, Hong Kong. 2006. |
Ma S.K.Y., Chan K.W., Hu L., Lee K.W., Ng I.O.L., Wo Y.H., Zheng B. and Guan X.Y., Identification and characterization of tumorigenic liver cancer stem cells, Proceedings of the Annual Meeting of American Association for Cancer Research, Los Angeles, USA, April. 2007. |
Ma S.K.Y., Chan K.W. and Guan X.Y., Identification and characterization of tumorigenic liver cancer stem cells, The 11th Research Postgraduate Symposium, The University of Hong Kong, December 2006, Hong Kong. 2006. |
Ma S.K.Y., Chan K.W., Hu L., Lee K.W., Wo Y.H., Ng I.O.L., Zheng B. and Guan X.Y., Identification and characterization of tumorigenic liver cancer stem/progenitor cells, Gastroenterology. 2007, 132(7): 2542-2556. |
Ma S.K.Y., Guan X.Y., Beh S.L., Wong K.Y., Chan Y.P., Yuen H.F., Vielkind J. and Chan K.W., The significance of LMO2 expression in the progression of prostate cancer, The Journal of Pathology. 2006, 211(3): 278-85. |
Tai A.L., Mak W., Ng P.K., Chua D.T., Ng
M.Y., Fu L., |
Tjia W.M., Hu L., Zhang M. and Guan X.Y., Characterization of rearrangements involving 4q, 13q and 16q in hepatocellular carcinoma cell lines using region-specific multiplex-FISH probes. , Cancer Letter. 2007, 250: 92-99. |
Wang L.D., Qin Y., Fan Z., Kwong D.L.W., Guan X.Y., Tsao G.S.W., Sham J., Li J.L. and Feng X.S., Comparative genomic hybridization: comparison between esophageal squamous cell carcinoma and gastric cardia adenocarcinoma from a high-incidence area for both cancers in Henan, northern China., Diseases of Esophagus. 2006, 19: 459-467. |
Xu F.P., Xie D., Wen J.M., Wu H.X., Liu Y.D., Bi J., Lv Z.L., Zeng Y.X. and Guan X.Y., SRC-3/AIB1 protein and gene amplification levels in human esophageal squamous cell carcinomas. , Cancer Letter. 2007, 245: 69-74. |
Zhang Z., Xie D., Li X., Wong Y.C., Xin D., Guan X.Y., Chua C.W., Leung S.C., Na Y. and Wang X., Significance of TWIST expression and its association with E-cadherin in bladder cancer., Human Pathology. 2007, 38: 598-606. |
Researcher
: Hu L |
List of Research Outputs |
Cheung C.M., Tang J.C.O., Lee P.Y., Hu L., Guan X.Y., Srivastava G., Wong J., Luk J.M.C. and Law S.Y.K., Establishment and characterization of a new xenograft-derived human esophageal squamous cell carcinoma cell line HKESC-4 of chinese origin, 11th Research Postgraduate Symposium (11th RPS), The University of Hong Kong Li Ka Shing Faculty of Medicine, Hong Kong, 7 December. 2006. |
Ma S.K.Y., Chan K.W., Hu L., Lee K.W., Ng I.O.L., Wo Y.H., Zheng B. and Guan X.Y., Identification and characterization of tumorigenic liver cancer stem cells, Proceedings of the Annual Meeting of American Association for Cancer Research, Los Angeles, USA, April. 2007. |
Ma S.K.Y., Chan K.W., Hu L., Lee K.W., Wo Y.H., Ng I.O.L., Zheng B. and Guan X.Y., Identification and characterization of tumorigenic liver cancer stem/progenitor cells, Gastroenterology. 2007, 132(7): 2542-2556. |
Tjia W.M., Hu L., Zhang M. and Guan X.Y., Characterization of rearrangements involving 4q, 13q and 16q in hepatocellular carcinoma cell lines using region-specific multiplex-FISH probes. , Cancer Letter. 2007, 250: 92-99. |
Researcher
: Kwong DLW |
Project Title: |
A pilot study for radiosensitization with COX-2 inhibitor for nasopharyngeal carcinoma |
Investigator(s): |
Kwong DLW, Nicholls JM |
Department: |
Clinical Oncology |
Source(s) of Funding: |
Small Project Funding |
Start Date: |
12/2005 |
Completion Date: |
11/2006 |
Abstract: |
1. To assess feasibility and toxicity of COX-2 inhibition in addition to radiotherapy/chemoradiation for nasopharyngeal carcinoma. 2. To assess molecular response in tumor to COX-2 inhibition by biopsies taken during treatment. Markers for COX-2, angiogenesis and proliferation will be studied by immunochemistry and RNA microarray. |
List of Research Outputs |
Baujat B., Audry H., Bourhis J., Chan A.T., Onat H., Chua D.T.T., Kwong D.L.W., Al-Saraff M., Chi K., Hareyama M., Leung S.F., Thephamongkhol K. and Pignon J., Chemotherapy as an adjunct to radiotherapy in locally advanced nasopharyngeal carcinoma., Cochrane Database Systemic Review. 2006, CD004329. |
Chiang A.K.S., Yuan X., Chan G.C.F., Kwong D.L.W., Chan T. and Ha S.Y., Treatment Outcome of Rhabdomyosarcoma in Hong Kong Chinese Children, 13th Hong Kong International Cancer Congress, 3rd Annual Meeting Centre for Cancer Research, HKU, 15-17 November 2006. |
Ho D.W.Y., Yang Z., Wong B.Y.H., Kwong D.L.W., Sham J.S.T., Wei W.I. and Yuen P.W., Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry serum protein profiling to identify nasopharyngeal carcinoma, Cancer. 2006, 107(1): 99-107. |
Ho W.K., Yang Z., Wong B.Y., Kwong D.L.W., Sham J.S.T., Wei W.I. and Yuen P.W., Cancer, Surface-enhanced laser desorption / ionization time-of-flight mass spectrometry serum protein profiling to identify nasopharyngeal carcinoma. 2006, 107: 99-107. |
Law S.Y.K., Kwong D.L.W., Wong K.H., Kwok K.F. and Wong J., The effects of neoadjuvant chemoradiation on pTNM staging and its prognostic significance in esophageal cancer, Journal of Gastrointestinal Surgery. 2006, 10(9): 1301-1311. |
Li J., Kwong D.L.W. and Chan G.C.F., The effects of various irradiation doses on the growth and differentiation of marrow deerived human mesenchymal stromal cells, The 11th Congress of the Asia Pacific Bone Marrow Transplantation (oral presentation), Nagoya, Japan, 27-29 October 2006. |
Li J., Kwong D.L.W. and Chan G.C.F., The effects of various irradiation doses on the growth and differentiation of marrow-derived human mesenchymal stromal cells, Pediatric Transplantation. Blackwell Munksgaard, 2007, 11: 379-387. |
McMillan A.S., Pow E.H.N., Kwong D.L.W., Wong M.C.M., Sham J.S.T., Leung L.H.T. and Leung W.K., Preservation of quality of life after intensity-modulated radiotherapy for early-stage nasopharyngeal carcinoma: Results of a prospective longitudinal study, Head & Neck. 2006, 28: 712-722. |
Nicholls J.M., Chan M.C.W., Chan W.Y., Wong H.K., Kwong D.L.W., Wong M.P., Chui W.H., Poon L.L.M., Tsao G.S.W., Guan Y. and Peiris J.S.M., Tropism of avian influenza A (H5N1) in the upper and lower respiratory tract, Nature Medicine. 2007, 13(2): 147-149. |
Pow E.H.N., Kwong D.L.W., McMillan A.S., Wong M.C.M., Sham J.S.T., Leung L.H.T. and Leung W.K., Xerostomia and quality of life after intensity-modulated radiotherapy vs. conventional radiotherapy for early-stage nasopharyngeal carcinoma: Initial report on a randomized control clinical trial., International Journal of Radiation Oncology, Biology, Physics. 2006, 66: 981-991. |
Qiu D., Kwong D.L.W., Chan G.C.F., Leung L.H.T. and Khong P.L., Diffusion tensor MR imaging finding of discrepant fractional anisotropy between the frontal and parietal lobes after whole-brain irradiation in childhood medulloblastoma survivors: reflection of regional white matter radiosensitivity? , Internal Journal of Radiation Oncology Biology Physics. 2007, 69: 846-851. |
Wang L.D., Qin Y., Fan Z., Kwong D.L.W., Guan X.Y., Tsao G.S.W., Sham J., Li J.L. and Feng X.S., Comparative genomic hybridization: comparison between esophageal squamous cell carcinoma and gastric cardia adenocarcinoma from a high-incidence area for both cancers in Henan, northern China., Diseases of Esophagus. 2006, 19: 459-467. |
Researcher
: Lee AWM |
List of Research Outputs |
Lee A.W.M., Tung S.Y., Chan A.T.C., Chappell R., Fu Y.T., Lu T.X., Tan T., Chua D.T.T., O'Sullivan B., Xu L., Pang E.S.Y., Sze W.M., Leung T.W., Kwan W.H., Chan P.T.M., Liu X.F., Tan E.H., Sham J.S.T., Siu L. and Lau W.H., Preliminary results of a prospective randomized study (NPC-9902 Trial) on the therapeutic gain by concurrent chemotherapy and/or accelerated fractionation for locally-advanced nasopharyngeal carcinoma, International Journal of Radiation Oncology Biology Physcis. 2006, 66: 142-151. |
Teo P.M., Leung S.F., Tung S.Y., Zee B., Sham J.S.T., Lee A.W.M., Lau W.H., Kwan W.H., Leung T.W. and Chua D.T.T., Dose-response relationship of nasopharyngeal carcinoma above conventional tumoricidal level: a study by the Hong Kong nasopharyngeal carcinoma study group (HKNPCSG), Radiotherapy Oncology. 2006, 79: 227-33. |
Researcher
: Leung TW |
List of Research Outputs |
Lee A.W.M., Tung S.Y., Chan A.T.C., Chappell R., Fu Y.T., Lu T.X., Tan T., Chua D.T.T., O'Sullivan B., Xu L., Pang E.S.Y., Sze W.M., Leung T.W., Kwan W.H., Chan P.T.M., Liu X.F., Tan E.H., Sham J.S.T., Siu L. and Lau W.H., Preliminary results of a prospective randomized study (NPC-9902 Trial) on the therapeutic gain by concurrent chemotherapy and/or accelerated fractionation for locally-advanced nasopharyngeal carcinoma, International Journal of Radiation Oncology Biology Physcis. 2006, 66: 142-151. |
Teo P.M., Leung S.F., Tung S.Y., Zee B., Sham J.S.T., Lee A.W.M., Lau W.H., Kwan W.H., Leung T.W. and Chua D.T.T., Dose-response relationship of nasopharyngeal carcinoma above conventional tumoricidal level: a study by the Hong Kong nasopharyngeal carcinoma study group (HKNPCSG), Radiotherapy Oncology. 2006, 79: 227-33. |
Researcher
: Qin Y |
List of Research Outputs |
Wang L.D., Qin Y., Fan Z., Kwong D.L.W., Guan X.Y., Tsao G.S.W., Sham J., Li J.L. and Feng X.S., Comparative genomic hybridization: comparison between esophageal squamous cell carcinoma and gastric cardia adenocarcinoma from a high-incidence area for both cancers in Henan, northern China., Diseases of Esophagus. 2006, 19: 459-467. |
Researcher
: Sham JST |
List of Research Outputs |
Chan
C.L.W., Ho T.H., Lee P.W.H., Cheng J.Y.Y., Leung P.P.Y.,
Foo W., Chow L.W.H., Sham J.S.T.
and Spiegel D., A Randomized Controlled Trial of Psychosocial Interventions
Using the Psychophysiological Framework for Chinese Breast Cancer Patients,
In: James R Zabora, Journal of Psychosocial Oncology. The |
Chua
D.T.T., Ma J., Sham J.S.T.,
|
Chua D.T.T., Sham J.S.T., Hung K.N., Leung H.T. and Au G.K.H., Predictive factors of tumor control and survival after radiosurgery of local failures of nasopharyngeal carcinoma., International Journal of Radiation Oncology Biology Physcis. 2006, 66: 1415-1421. |
Ho D.W.Y., Yang Z., Wong B.Y.H., Kwong D.L.W., Sham J.S.T., Wei W.I. and Yuen P.W., Surface-enhanced laser desorption/ionization time-of-flight mass spectrometry serum protein profiling to identify nasopharyngeal carcinoma, Cancer. 2006, 107(1): 99-107. |
Ho W.K., Yang Z., Wong B.Y., Kwong D.L.W., Sham J.S.T., Wei W.I. and Yuen P.W., Cancer, Surface-enhanced laser desorption / ionization time-of-flight mass spectrometry serum protein profiling to identify nasopharyngeal carcinoma. 2006, 107: 99-107. |
Ji M.F., Wang D.K., Yu Y.L., Guo Y.Q., Liang J.S., Cheng W.M., Zong Y.S., Chan K.H., Ng S.P., Wei W.I., Chua D.T.T., Sham J.S.T. and Ng M.H., Sustained elevation of Epstein-Barr virus antibody levels preceding clinical onset of nasopharyngeal carcinoma., British Journal of Cancer. 2007, 96: 623-630. |
Lee A.W.M., Tung S.Y., Chan A.T.C., Chappell R., Fu Y.T., Lu T.X., Tan T., Chua D.T.T., O'Sullivan B., Xu L., Pang E.S.Y., Sze W.M., Leung T.W., Kwan W.H., Chan P.T.M., Liu X.F., Tan E.H., Sham J.S.T., Siu L. and Lau W.H., Preliminary results of a prospective randomized study (NPC-9902 Trial) on the therapeutic gain by concurrent chemotherapy and/or accelerated fractionation for locally-advanced nasopharyngeal carcinoma, International Journal of Radiation Oncology Biology Physcis. 2006, 66: 142-151. |
Lee D.C.W., Chua D.T.T., Sham J.S.T., Wei W.I. and Lau A.S.Y., Differential induction of matrix metallo-proteinase 3 by Epstein-Barr virus latent membrane protein 1, Organisation for Oncology and Translational Research 3rd Annual Conference, Hong Kong Academy of Medicine (Neoadjuvant & Molecular Therapy in Cancer), 22-23 September 2006. |
Lee D.C.W., Chua D.T.T., Sham J.S.T. and Lau A.S.Y., Epstein-Barr virus latent membrane protein 1 enhances matrix metalloproteinase 3 induction in human fibroblast, The 6th International Cytokine Conference 2006 (European Cytokine Network, Supplement Aug 2006, Vol 17 - as official journal of Cytokine 2006-Vienna), Vienna, Austria, 27-31 August 2006. 17: 14-06/P. |
Lee D.C.W., Chua D.T.T., Sham J.S.T. and Lau A.S.Y., Expression of Matrix Metallo-proteinase 3 by Epstein-Barr Virus Latent Membrane Protein 1, 6th International Cytokine Conference Proceedings, Medimond International Proceedings, Bologna, Italy, 27-31 August 2006. 101-104. |
Lung H.L., Cheung A.K.L., Xie D., Cheng Y., Kwong F.M., Murakami Y., Guan X.Y., Sham J.S.T., Chua D.T.T., Protopopov A.I., Zabarovsky E.R., Tsao G.S.W., Stanbridge E.J. and Lung M.L., TSLC1 is a tumor suppressor gene associated with metastasis in nasopharyngeal carcinoma, Cancer Research. 2006, 66(19): 9385-9392. |
McMillan A.S., Pow E.H.N., Kwong D.L.W., Wong M.C.M., Sham J.S.T., Leung L.H.T. and Leung W.K., Preservation of quality of life after intensity-modulated radiotherapy for early-stage nasopharyngeal carcinoma: Results of a prospective longitudinal study, Head & Neck. 2006, 28: 712-722. |
Pow E.H.N., Kwong D.L.W., McMillan A.S., Wong M.C.M., Sham J.S.T., Leung L.H.T. and Leung W.K., Xerostomia and quality of life after intensity-modulated radiotherapy vs. conventional radiotherapy for early-stage nasopharyngeal carcinoma: Initial report on a randomized control clinical trial., International Journal of Radiation Oncology, Biology, Physics. 2006, 66: 981-991. |
Teo P.M., Leung S.F., Tung S.Y., Zee B., Sham J.S.T., Lee A.W.M., Lau W.H., Kwan W.H., Leung T.W. and Chua D.T.T., Dose-response relationship of nasopharyngeal carcinoma above conventional tumoricidal level: a study by the Hong Kong nasopharyngeal carcinoma study group (HKNPCSG), Radiotherapy Oncology. 2006, 79: 227-33. |
Yau W.L., Lung H.L., Zabarovsky E.R.,
Lerman M.I., Sham J.S.T., Chua D.T.T., Tsao G.S.W., Stanbridge E.J. and Lung
M.L., Functional studies of the chromosome 3p21.3 candidate tumor suppressor
gene BLU/ZMYND |
Researcher
: Sze WM |
List of Research Outputs |
Lee A.W.M., Tung S.Y., Chan A.T.C., Chappell R., Fu Y.T., Lu T.X., Tan T., Chua D.T.T., O'Sullivan B., Xu L., Pang E.S.Y., Sze W.M., Leung T.W., Kwan W.H., Chan P.T.M., Liu X.F., Tan E.H., Sham J.S.T., Siu L. and Lau W.H., Preliminary results of a prospective randomized study (NPC-9902 Trial) on the therapeutic gain by concurrent chemotherapy and/or accelerated fractionation for locally-advanced nasopharyngeal carcinoma, International Journal of Radiation Oncology Biology Physcis. 2006, 66: 142-151. |
Researcher
: Tjia WM |
List of Research Outputs |
Tjia W.M., Hu L., Zhang M. and Guan X.Y., Characterization of rearrangements involving 4q, 13q and 16q in hepatocellular carcinoma cell lines using region-specific multiplex-FISH probes. , Cancer Letter. 2007, 250: 92-99. |
Researcher
: Xie D |
List of Research Outputs |
Lung H.L., Cheung A.K.L., Xie D., Cheng Y., Kwong F.M., Murakami Y., Guan X.Y., Sham J.S.T., Chua D.T.T., Protopopov A.I., Zabarovsky E.R., Tsao G.S.W., Stanbridge E.J. and Lung M.L., TSLC1 is a tumor suppressor gene associated with metastasis in nasopharyngeal carcinoma, Cancer Research. 2006, 66(19): 9385-9392. |
Xu F.P., Xie D., Wen J.M., Wu H.X., Liu Y.D., Bi J., Lv Z.L., Zeng Y.X. and Guan X.Y., SRC-3/AIB1 protein and gene amplification levels in human esophageal squamous cell carcinomas. , Cancer Letter. 2007, 245: 69-74. |
Zhang Z., Xie D., Li X., Wong Y.C., Xin D., Guan X.Y., Chua C.W., Leung S.C., Na Y. and Wang X., Significance of TWIST expression and its association with E-cadherin in bladder cancer., Human Pathology. 2007, 38: 598-606. |
Researcher
: Zhang M |
List of Research Outputs |
Tjia W.M., Hu L., Zhang M. and Guan X.Y., Characterization of rearrangements involving 4q, 13q and 16q in hepatocellular carcinoma cell lines using region-specific multiplex-FISH probes. , Cancer Letter. 2007, 250: 92-99. |
-- End of Listing --