DENTAL FACULTY - ENDODONTOLOGY



Researcher : Chang JWW

Project Title:Diagnostic and prognostic markers related to pathogenic bacteria in endodontic lesions of failed cases
Investigator(s):Chang JWW, Seneviratne CJ, Samaranayake LP, Cheung GSP
Department:Dental Faculty
Source(s) of Funding:Small Project Funding
Start Date:04/2011


List of Research Outputs

Chang J.W.W., Endodontoc Irrigation Quo vadis, 8th vietnam internationational dental congress FDI. 2015.
Chang J.W.W., Root Canal Instrumentation - "Influence of File Design", Society of Endodontists Singapore Scientific Meeting 2015. 2015.


Researcher : Cheung GSP

Project Title:Stem cells in human dental pulp with irreversible pulpitis and their potential for tissue regeneration
Investigator(s):Cheung GSP, Zhang C, Chang JWW
Department:Dental Faculty
Source(s) of Funding:Small Project Funding
Start Date:03/2011


List of Research Outputs

Chan E.L.K., Zhang C. and Cheung G.S.P., Cytotoxicity of a novel nano-silver particle endodontic irrigant, Clinical, Cosmetic and Investigational Dentistry. 2015, 7: 65-74.
Cheung G.S.P., BDS curriculum in HKU. HKU Faculty of Dentistry's 2nd position in the QS Ranking, Faculty of Dentistry, Universitas Gadjah Mada, Yogyakarta, Indonesia. 2015.
Cheung G.S.P., Cutting edge of root canal preparation, 2015 Korean Academy of Conservative Dentistry Autumn Scientific Meeting, Seoul, Korea. 2015.
Cheung G.S.P., Dental cracks - a restorative conundrum. Bonding in the root canal. Assisted root canal irrigation. Pulp revascularization and regeneration, One-day course for the Australian Society of Endodontology, Perth, Australia. 2016.
Cheung G.S.P., Evolving treatment philosophies and ways to optimize endodontic success, Oral Department, Sun Yat-sen University Hospital, Guangzhou, PRC. 2015.
Cheung G.S.P., International Capstone Experience - WATOTO Project 2015, Watoto Asia. 2015.
Cheung G.S.P., Managing the root canal biofilm: strategy and possibility, The 23rd Convocation of the Royal Australasian College of Dental Surgeons, Hobart, Tasmania. 2016.
Cheung G.S.P., NiTi Instruments: The Way Forward, Society of Endodontists Singapore Scientific Meeting 2015. 2015.
Dorn S.O. and Cheung G.S.P., Management of Endodontic Emergencies, Cohen's Pathways of the Pulp. Elsevier, 2015, Eleventh Edition: 706-721.
Gao S.Q., Tsoi K.H., Cheung G.S.P. and Matinlinna J.P., An in vitro Evaluation on a Novel Root Canal Cleansing Method by Using Nylon Fibers, In: Jack Gillespie, Fibers. 2015, 3: 197-205.
Ha J.H., Cheung G.S.P., Versluis A., Lee C.J., Kwak S.W. and Kim H.C., ‘Screw-in’ tendency of rotary nickel-titanium files due to design geometry, International Endodontic Journal. 2015, 48: 666-672.
Heng B.C.A., Ye X., LIU Y., Dissanayaka W.L., Cheung G.S.P. and Zhang C., Effects of Recombinant Overexpression of Bcl2 on the Proliferation, Apoptosis, and Osteogenic/Odontogenic Differentiation Potential of Dental Pulp Stem Cells, Journal of Endodontics. 2016, 42: 575-583.
Liu L., Shu S., Cheung G.S.P. and Wei X., Effect of miR-146a/bFGF/PEG-PEI Nanoparticles on Inflammation Response and Tissue Regeneration of Human Dental Pulp Cells, BioMed Research International. 2016, 2016: 1-12.
Liu P., McGrath C.P.J. and Cheung G.S.P., Predictors of improvements in oral health-related quality-of-life following endodontic treatment, Journal of Dental Research. 2015, 94 (Spec Iss B): 125 (SEA Division).
Min Y., Ma J.Z., Shen Y., Cheung G.S.P. and Gao Y., A micro-computed tomography study of the negotiation and anatomical feature in apical root canal of mandibular molars, Scanning. 2016, 9999: 1-6.
She C.M.L., Cheung G.S.P. and Zhang C., Long-Term Follow-Up of a Revascularized Immature Necrotic Tooth Evaluated by CBCT, Case Reports in Dentistry. 2016, 2016: 1-5.
Siew K.L., Lee A.H.C. and Cheung G.S.P., Treatment Outcome of Repaired Root Perforation: A Systematic Review and Meta-analysis, Journal of Endodontics. 2015, 41(11): 1795-1804.
WANG S., LIU K., SENEVIRATNE J.S., Li X.C., Cheung G.S.P., Jin L., Chu C.H. and Zhang C., Lipoteichoic acid from an Enterococcus faecalis clinical strain promotes TNF-α expression through the NF-κB and p38 MAPK signaling pathways in differentiated THP-1 macrophages, Biomedical Reports. 2015, 3: 697-702.
WANG S., Deng Z., Seneviratne C.J., Cheung G.S.P., Jin L., Zhao B. and Zhang C., Enterococcus faecalis promotes osteoclastogenesis and semaphorin 4D expression, Innate Immunity. 2015, 21: 726-735.
Yang Q., Cheung G.S.P., Shen Y., Huang D., Zhou X. and Gao Y., The remaining dentin thickness investigation of the attempt to remove broken instrument from mesiobuccal canals of maxillary first molars with virtual simulation technique, BMC Oral Health. 2015, 15: 1-8.


Researcher : Dissanayaka WL

Project Title:Characterization of single cell-derived clones of dental pulp stem cells
Investigator(s):Dissanayaka WL, Zhang C
Department:Dental Faculty - Endodontology
Source(s) of Funding:Small Project Funding
Start Date:05/2015


List of Research Outputs

Dissanayaka W.L., 2016 IADR William J Gies Award for Biomaterials and Bioengineering Research, International Association of Dental Research. 2016.
Dissanayaka W.L., ZHU L., Hargreaves K.M., Jin L. and Zhang C., 2016 IADR/AADR William J. Gies Award for Biomaterials and Bioengineering Research, IADR/AADR. 2016.
Dissanayaka W.L., ZHU L., Hargreaves K.M., Jin L. and Zhang C., 2016 Journal of Endodontics Awards, the best articles published in JOE during the 2015 calendar year, 2016.
Dissanayaka W.L., Journal of Endodontics Award for the Best Paper in Basic Science: Biology 2016, Journal of Endodontics & American Association of Endodontists. 2016.
Heng B.C.A., Ye X., LIU Y., Dissanayaka W.L., Cheung G.S.P. and Zhang C., Effects of Recombinant Overexpression of Bcl2 on the Proliferation, Apoptosis, and Osteogenic/Odontogenic Differentiation Potential of Dental Pulp Stem Cells, Journal of Endodontics. 2016, 42: 575-583.


Researcher : GONG T

List of Research Outputs

GONG T., Heng B.C.A., Lo E.C.M. and Zhang C., Current Advance and Future Prospects of Tissue Engineering Approach to Dentin/Pulp Regenerative Therapy, Stem Cells International. 2016, 2016: 1-13.
Heng B.C.A., Zhu S., XU J., YUAN C., GONG T. and Zhang C., Effects of decellularized matrices derived from periodontal ligament stem cells and SHED on the adhesion, proliferation and osteogenic differentiation of human dental pulp stem cells in vitro, Tissue and Cell. 2016, 48: 133-143.


Researcher : Heng BCA

List of Research Outputs

Deng Z., Wang S., Heng B.C.A., YUAN C. and Zhang C., Enterococcus faecalis promotes osteoclast differentiation within an osteoblast/osteoclast co-culture system, Biotechnology Letters. 2016, 38: 1443-1448.
GONG T., Heng B.C.A., Lo E.C.M. and Zhang C., Current Advance and Future Prospects of Tissue Engineering Approach to Dentin/Pulp Regenerative Therapy, Stem Cells International. 2016, 2016: 1-13.
Heng B.C.A., Lim L.W., Wu W. and Zhang C., An overview of protocols for the neural induction of dental and oral stem cells in vitro, In: Antonios G. Mikos; John P. Fisher, Tissue Engineering Part B: Reviews . Mary Ann liebert, 2016, 22 (3): 220-250.
Heng B.C.A., Ye X., LIU Y., Dissanayaka W.L., Cheung G.S.P. and Zhang C., Effects of Recombinant Overexpression of Bcl2 on the Proliferation, Apoptosis, and Osteogenic/Odontogenic Differentiation Potential of Dental Pulp Stem Cells, Journal of Endodontics. 2016, 42: 575-583.
Heng B.C.A., Zhu S., XU J., YUAN C., GONG T. and Zhang C., Effects of decellularized matrices derived from periodontal ligament stem cells and SHED on the adhesion, proliferation and osteogenic differentiation of human dental pulp stem cells in vitro, Tissue and Cell. 2016, 48: 133-143.
Heng B.C.A., Aubel D. and Fussenegger M., Prosthetic gene networks as an alternative to standard pharmacotherapies for metabolic disorders, Current Opinion in Biotechnology. 2015, 35: 37-45.
Hu J.J., Yin Z., Shen W.L., Xie Y.B., Zhu T., Lu P., Cai Y.Z., Kong M.J., Heng B.C.A., Zhou Y.T., Chen W.S., Chen X. and Ouyang H.W., Pharmacological Regulation of In Situ Tissue Stem Cells Differentiation for Soft Tissue Calcification Treatment., Stem Cells. 2016, 34: 1083-96.
Li M., Zou Y., Tang N., Heng B.C.A., Islam I., Tong H.J., Dawe G.S. and Cao T., Efficient derivation of dopaminergic neurons from SOX1(-) floor plate cells under defined culture conditions., Journal of Biomedical Science. 2016, 23(1): 34.
Pratik S., Heng B.C.A., Bai P., Folcher M., Zulewski H. and Fussenegger M., A programmable synthetic lineage-control network that differentiates human IPSCs into glucose-sensitive insulin-secreting beta-like cells, Nature Communications. 2016, 7: 11247.
Wang J., Wang J., Lu P., Cai Y., Wang Y., Hong L., Ren H., Heng B.C.A., Liu H., Zhou J. and Ouyang H., Local delivery of FTY720 in PCL membrane improves SCI functional recovery by reducing reactive astrogliosis, Biomaterials. 2015, 62: 76-87.
Wang Q., Xia Q., Wu Y., Zhang X., Wen F., Chen X., Zhang S., Heng B.C.A., He Y. and Ouyang H.W., 3D-Printed Atsttrin-Incorporated Alginate/Hydroxyapatite Scaffold Promotes Bone Defect Regeneration with TNF/TNFR Signaling Involvement., Advanced Healthcare Materials. 2015, 4: 1701-8.
Xu W.L., Jiang S., Chen C., Ye Y.U., Chen J., Heng B.C.A., Jiang Q., Wu B., Ding Z. and Zhang C., Systemically Transplanted Bone Marrow–derived Cells Contribute to Dental Pulp Regeneration in a Chimeric Mouse Model, Journal of Endodontics. 2016, 42: 263-268.
Yap M.S., Tang Y.Q., Yeo Y., Lim W.L., Lim L.W., Tan K.O., Richards M., Othman L., Poh C.L. and Heng B.C.A., Pluripotent Human embryonic stem cell derived neural lineages for in vitro modelling of enterovirus 71 infection and therapy, Virology Journal. 2016, 13.
Zhang X., Wu Y., Pan Z., Sun H., Wang J., Yu D., Zhu S., Dai J., Chen Y., Tian N., Heng B.C.A., Coen N.D., Xu H. and Ouyang H., The effects of lactate and acid on articular chondrocytes function: Implications for polymeric cartilage scaffold design, Acta Biomaterialia. 2016.
Zhou L., Wang P., Zhang J., Heng B.C.A. and Tong G.Q., ING2 (inhibitor of growth protein-2) plays a crucial role in preimplantation development, Zygote. 2016, 24: 89-97.


Researcher : Lee AHC

List of Research Outputs

Lee A.H.C., Diagnosis and Management of Perio-Endo Lesions, Philippine Society of Periodontology, 8 November 2015, The Philippines. 2015.
Siew K.L., Lee A.H.C. and Cheung G.S.P., Treatment Outcome of Repaired Root Perforation: A Systematic Review and Meta-analysis, Journal of Endodontics. 2015, 41(11): 1795-1804.


Researcher : Li D

List of Research Outputs

JIANG S., Li D. and Zhang C., Effectiveness of sonic, ultrasonic and laser irrigation on filling materials removal in premolar root canals, Journal of Dental Research. 2015, 94 (Spec Iss B): 162 (SEA Division).


Researcher : PANDUWAWALA KANKANAMALAGE CPPP

List of Research Outputs

Leung A.S.L., PANDUWAWALA KANKANAMALAGE C.P.P.P. and McGrath C.P.J., Traditional ayurvedic oral health practices: A systematic review, Journal of Dental Research. 2015, 94 (Spec Iss B): 032 (SEA Division).


Researcher : XU J

List of Research Outputs

Heng B.C.A., Zhu S., XU J., YUAN C., GONG T. and Zhang C., Effects of decellularized matrices derived from periodontal ligament stem cells and SHED on the adhesion, proliferation and osteogenic differentiation of human dental pulp stem cells in vitro, Tissue and Cell. 2016, 48: 133-143.


Researcher : YUAN C

List of Research Outputs

Deng Z., Wang S., Heng B.C.A., YUAN C. and Zhang C., Enterococcus faecalis promotes osteoclast differentiation within an osteoblast/osteoclast co-culture system, Biotechnology Letters. 2016, 38: 1443-1448.
Heng B.C.A., Zhu S., XU J., YUAN C., GONG T. and Zhang C., Effects of decellularized matrices derived from periodontal ligament stem cells and SHED on the adhesion, proliferation and osteogenic differentiation of human dental pulp stem cells in vitro, Tissue and Cell. 2016, 48: 133-143.


Researcher : Ye X

List of Research Outputs

Heng B.C.A., Ye X., LIU Y., Dissanayaka W.L., Cheung G.S.P. and Zhang C., Effects of Recombinant Overexpression of Bcl2 on the Proliferation, Apoptosis, and Osteogenic/Odontogenic Differentiation Potential of Dental Pulp Stem Cells, Journal of Endodontics. 2016, 42: 575-583.


Researcher : Zhang C

Project Title:Prevascularized periodontal ligament cell sheet with endothelial cells promotes periodontal tissue complex regeneration
Investigator(s):Zhang C, Chu CH
Department:Dental Faculty - Endodontology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:04/2012


Project Title:Bcl-2 and cMyc gene-transfected dental pulp stem cells outcompete bone marrow-derived cells in dental pulp regeneration
Investigator(s):Zhang C, Cheung GSP, Chang JWW
Department:Dental Faculty - Endodontology
Source(s) of Funding:National Natural Science Foundation of China (NSFC) - General Program
Start Date:01/2013


Project Title:Engineering human dental pulp tissues using prevascularized microtissue spheroids constructed by dental pulp stem cells and gene-modified endothelial cells
Investigator(s):Zhang C, Cheung GSP, Jin L, Seneviratne CJ
Department:Dental Faculty
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2013
Completion Date:12/2015


Project Title:Lipoteichoic acid (LTA) of pathogenic Enterococcus faecalis modulates the functional characteristics of osteoblasts and osteoclasts
Investigator(s):Zhang C, Seneviratne CJ, Jin L, Watt RM, Li XC
Department:Dental Faculty - Endodontology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:01/2013
Completion Date:04/2016


Project Title:Hypoxia enhances the angiogenic potential of stem cells from apical papilla via upregulation of VEGF and ephrinB2 expression
Investigator(s):Zhang C
Department:Dental Faculty - Endodontology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:06/2014


Project Title:EphrinB2 and VEGF cooperatively regulate dental pulp stem cell functions and blood vessel formation
Investigator(s):Zhang C, Jin L, Cheung GSP
Department:Dental Faculty - Endodontology
Source(s) of Funding:National Natural Science Foundation of China (NSFC) - General Program
Start Date:01/2015


Project Title:EphrinB2 enhances angiogenesis and anastomosis of bioengineered prevascularized dental pulp construct
Investigator(s):Zhang C, Cheung GSP, Jin L, Green DW
Department:Dental Faculty - Endodontology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2015


Project Title:Semaphorin 4D on angiogenesis and odontogenesis of human dental pulp stem cells
Investigator(s):Zhang C
Department:Dental Faculty - Endodontology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:04/2015


Project Title:Bcl-2 overexpression in human DPSCs promotes angiogenesis through VEGF and HIF-1α activity
Investigator(s):Zhang C, Dissanayaka WL
Department:Dental Faculty - Endodontology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:04/2016


Project Title:94th General Session & Exhibition of the International Association for Dental Research (IADR); Transgenic expression of ephrinB2 in PDLSCs modulates osteogenic differentiation via signaling crosstalk between ephrinB2 and EphB4 in PDLSCs and between PDLSCs and pre-osteoblasts within co-culture
Investigator(s):Zhang C
Department:Dental Faculty - Endodontology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2016
Completion Date:06/2016


List of Research Outputs

Bhoj M., Zhang C. and Green D.W., 2016 Journal of Endodontics Awards (honorable mentions) articles published in JOE during the 2015 calendar year, 2016.
Bhoj M., Zhang C. and Green D.W., A First Step in De Novo Synthesis of a Living Pulp Tissue Replacement Using Dental Pulp MSCs and Tissue Growth Factors, Encapsulated within a Bioinspired Alginate Hydrogel, Journal of Endodontics. 2015, 41: 1100-1107.
Chan E.L.K., Zhang C. and Cheung G.S.P., Cytotoxicity of a novel nano-silver particle endodontic irrigant, Clinical, Cosmetic and Investigational Dentistry. 2015, 7: 65-74.
Deng Z., Wang S., Heng B.C.A., YUAN C. and Zhang C., Enterococcus faecalis promotes osteoclast differentiation within an osteoblast/osteoclast co-culture system, Biotechnology Letters. 2016, 38: 1443-1448.
Dissanayaka W.L., ZHU L., Hargreaves K.M., Jin L. and Zhang C., 2016 IADR/AADR William J. Gies Award for Biomaterials and Bioengineering Research, IADR/AADR. 2016.
Dissanayaka W.L., ZHU L., Hargreaves K.M., Jin L. and Zhang C., 2016 Journal of Endodontics Awards, the best articles published in JOE during the 2015 calendar year, 2016.
GONG T., Heng B.C.A., Lo E.C.M. and Zhang C., Current Advance and Future Prospects of Tissue Engineering Approach to Dentin/Pulp Regenerative Therapy, Stem Cells International. 2016, 2016: 1-13.
Heng B.C.A., Lim L.W., Wu W. and Zhang C., An overview of protocols for the neural induction of dental and oral stem cells in vitro, In: Antonios G. Mikos; John P. Fisher, Tissue Engineering Part B: Reviews . Mary Ann liebert, 2016, 22 (3): 220-250.
Heng B.C.A., Ye X., LIU Y., Dissanayaka W.L., Cheung G.S.P. and Zhang C., Effects of Recombinant Overexpression of Bcl2 on the Proliferation, Apoptosis, and Osteogenic/Odontogenic Differentiation Potential of Dental Pulp Stem Cells, Journal of Endodontics. 2016, 42: 575-583.
Heng B.C.A., Zhu S., XU J., YUAN C., GONG T. and Zhang C., Effects of decellularized matrices derived from periodontal ligament stem cells and SHED on the adhesion, proliferation and osteogenic differentiation of human dental pulp stem cells in vitro, Tissue and Cell. 2016, 48: 133-143.
JIANG S., Li D. and Zhang C., Effectiveness of sonic, ultrasonic and laser irrigation on filling materials removal in premolar root canals, Journal of Dental Research. 2015, 94 (Spec Iss B): 162 (SEA Division).
Jiang S., Zhang C. and Wu H., Partial pulpotomy of immature teeth with apical periodontitis using bioceramics and mineral trioxide aggregate: a report of three cases, Chin J Dent Res. 2016, 19(2): 115-120.
LI X., Wong C.H., Ng T.W., Zhang C., Leung K.C.F. and Jin L., The spherical nanoparticle-encapsulated chlorhexidine enhances anti-biofilm efficiency through an effective releasing mode and close microbial interactions, International Journal of Nanomedicine. 2016, 2471-2480.
REN C., McGrath C.P.J., Jin L., Zhang C. and Yang Y., The effectiveness of low-level laser therapy as an adjunct to non-surgical periodontal treatment: a meta-analysis., J Periodontal Res. 2016.
She C.M.L., Cheung G.S.P. and Zhang C., Long-Term Follow-Up of a Revascularized Immature Necrotic Tooth Evaluated by CBCT, Case Reports in Dentistry. 2016, 2016: 1-5.
WANG S., LIU K., SENEVIRATNE J.S., Li X.C., Cheung G.S.P., Jin L., Chu C.H. and Zhang C., Lipoteichoic acid from an Enterococcus faecalis clinical strain promotes TNF-α expression through the NF-κB and p38 MAPK signaling pathways in differentiated THP-1 macrophages, Biomedical Reports. 2015, 3: 697-702.
WANG S., Deng Z., Seneviratne C.J., Cheung G.S.P., Jin L., Zhao B. and Zhang C., Enterococcus faecalis promotes osteoclastogenesis and semaphorin 4D expression, Innate Immunity. 2015, 21: 726-735.
Wang Y., Zhu X. and Zhang C., Pulp Revascularization on Permanent Teeth with Open Apices in a Middle-aged Patient, Journal of Endodontics. 2015, 41: 1571-1575.
Wong A.W.Y., Zhu X.F., Zhang S., Li K.Y., Zhang C. and Chu C.H., Treatment time for non-surgical endodontic therapy with or without a magnifying loupe, BMC Oral Health. 2015, 15.
Xu W.L., Jiang S., Chen C., Ye Y.U., Chen J., Heng B.C.A., Jiang Q., Wu B., Ding Z. and Zhang C., Systemically Transplanted Bone Marrow–derived Cells Contribute to Dental Pulp Regeneration in a Chimeric Mouse Model, Journal of Endodontics. 2016, 42: 263-268.
Yang Y., LIAO C., Jin L. and Zhang C., IL-17 expression and its effect on osteoclastogenesis under mechanical loading, Journal of Dental Research. 2016, 95 (Spec Iss B): 1666.
Zhang C., Modern technique of root canal therapy, 11 March, 2016, Shenyang, China, 2016.
Zhang C., The interplay of dental pulp stem cells and endothelial cells in an injectable peptide hydrogel on angiogenesis and pulp regeneration in vivo, The award of the 2016 Research Output Prize. 2016.
Zhang C., Topic: Derivation of endothelial and vascular smooth muscle cells from SHED for pulp regeneration., 2016 94th General Session & Exhibition of the IADR in conjunction with the 3rd Meeting of the IADR Asia Pacific Region and the 35th Annual Meeting of the IADR Korean Division in Seoul, Republic of Korea. Symposium on “Clinical Translational Research on Dental Pulp Regeneration”.. 2016.
Zhang C., Topic: The role of scaffolding and prevascularization in pulp regeneration., International Association for Dental Research (IADR) Pulp Biology Regeneration Group (PBRG) Symposium 2016, 26th-28th June 2016, Nagoya, Japan. 2016.
Zhou X., Jiang S., Wang X., WANG S., Zhu X. and Zhang C., Comparison of dentinal and apical crack formation caused by four different nickel-titanium rotary and reciprocating systems in large and small canals, Dental Materials Journal. 2015, 34: 903-909.
Zhu J., Li X., Zhu F., Chen L., Zhang C., McGrath C.P.J., He F., Xiao Y. and Jin L., Multiple tooth loss is associated with vascular cognitive impairment in subjects with acute ischemic stroke, Journal of Periodontal Research. 2015, 50: 683-688.


Researcher : Zhu S

List of Research Outputs

Heng B.C.A., Zhu S., XU J., YUAN C., GONG T. and Zhang C., Effects of decellularized matrices derived from periodontal ligament stem cells and SHED on the adhesion, proliferation and osteogenic differentiation of human dental pulp stem cells in vitro, Tissue and Cell. 2016, 48: 133-143.


-- End of Listing --