SCHOOL OF BIOMEDICAL SCIENCES
| Researcher : AN L |
| List of Research Outputs |
| AN L., JIANG Y., Ng H.W.H., CHEN J., GONG Q. and Huen M.S.Y., USP7 Enforces RNF169-dependent DNA Double-Strand Break Responses, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Researcher : Au YK |
| List of Research Outputs |
| Cheah K.S.E., Au Y.K., Wynn S., Tan T., YIP K.H.R. and Chan D., Genetic control of hypertrophic chondrocyte to osteoblast differentiation in development and skeletal disorders, American Association of Anatomists (AAA) 2016 Annual Meeting. 2016. |
| Cheah K.S.E., Au Y.K., Wynn S., Tan T., YIP K.H.R. and Chan D., Genetic control of hypertrophic chondrocyte to osteoblast differentiation in development and skeletal disorders, American Association of Anatomists (AAA) 2016 Annual Meeting, San Diego, USA, April 2-6, 2016.. 2016. |
| Cheah K.S.E., Au Y.K., Niu B., Chan D. and Zhang M.Q., SPINE-GEL: a global gene expression library for the developing nucleus pulposus., Spine Week, Singapore, May 16-20, 2016. |
| GUO S., Tsang K.Y., Au Y.K., Tam W.K., Leung V.Y.L. and Cheah K.S.E., Generation of a Chordoma Cell Line: a Model of Human Notochordal Cells?, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| LIM F.L., ZHANG C., Tam W.K., Au Y.K., Chan D., Tuan R.S., Cheah K.S.E., Cheung K.M.C. and Leung V.Y.L., Nucleus Pulposus Cell Vacuolation: A New Perspective From N-Cadherin/Cadherin 2 Function, ORS 3rd International Spine Research Symposium, Philadelphia, USA . 2015. |
| Szeto Y.Y., Chu K.H., Au Y.K., Huang Y.H., Wynn S., Mak A., Chan Y.S., Lovell-Badge R., Chan W.Y., Jauch R., Fritzsch B., Sham M.H. and Cheah K.S.E., The SOX9Y440X campomelic dysplasia mutation disrupts endolymph homeostasis., Gordon Research Conference: Fibroblast Growth Factors in Development & Disease. 2016. |
| YIP K.H.R., Au Y.K., Chan D. and Cheah K.S.E., Investigating molecular pathogenesis of Campomelic Dysplasia, 2016 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| YIP K.H.R., Au Y.K., Chan D. and Cheah K.S.E., Investigating molecular pathogenesis of Campomelic Dysplasia, 2016 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, The Chinese University of Hong Kong, June 11, 2016. |
| YIP K.H.R., Au Y.K., Chan D. and Cheah K.S.E., Investigating molecular pathogenesis of Campomelic Dysplasia, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| ZHANG C., LIM F.L., Tam W.K., Au Y.K., Cheah K.S.E., Cheung K.M.C. and Leung V.Y.L., Cadherin2/N-cadherin Deficiency In Nucleus Pulposus Causes Loss Of Cell Vacuolation And Disc Integrity, 62nd Annual Meeting of Orthopaedic Research Society, Orlando, USA. 2016. |
| Researcher : Ballard HJ |
| Project Title: | ATP release from vascular endothelium and erythrocytes during skeletal muscle contraction |
| Investigator(s): | Ballard HJ |
| Department: | Physiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | Involvement of Pannexin 1 in CFTR-regulated ATP release from skeletal muscle |
| Investigator(s): | Ballard HJ |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2015 |
| Project Title: | Transmembrane-channel interactions in pre- and post-ischaemic cardioprotection |
| Investigator(s): | Ballard HJ |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2016 |
| Researcher : CAO F |
| List of Research Outputs |
| Yu C., Rafiq N.B.M., CAO F., ZHOU Y., Krishnasamy A., Biswas K.H., Ravasio A., Chen Z., Wang Y., Kawauchi K., Jones G.E. and Sheetz M.P., Integrin-beta3 clusters recruit clathrin-mediated endocytic machinery in the absence of traction force, Nature Communications. 2015, 6: 8672. |
| Researcher : CHAI S |
| List of Research Outputs |
| Lau Y.T., Lo J., CHENG Y.L.B., MA K.F., Lee M.F., Ng K.Y., CHAI S., Lin C., Tsang F.S., Ma S.K.Y., Ng I.O.L. and Lee K.W., Cancer-associated fibroblasts regulate tumor-initiating cell plasticity in hepatocellular carcinoma through c-Met/FRA1/HEY1 signaling, Cell Reports. 2016, 15: 1175-89. |
| Researcher : CHAN HL |
| List of Research Outputs |
| CHAN H.L., Huang J. and Lai K.O., The Kinesin motor protein KIF5B regulates RNA trafficking and dendritic spine morphogenesis in hippocampal neuron, HKU State Key Laboratory Neuroscience Symposium 2016 and Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| CHAN H.L., Huang J. and Lai K.O., The Kinesin motor protein KIF5B regulates RNA trafficking and dendritic spine morphogenesis in hippocampal neuron, Inter-University Postgraduate Symposium in Biochemical Sciences . 2016. |
| CHAN H.L., Huang J. and Lai K.O., The kinesin motor protein KIF5B regulates RNA trafficking and dendritic spine morphogenesis in hippocampal neuron, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| CHAN H.L., Huang J. and Lai K.O., The kinesin motor protein KIF5B regulates RNA trafficking and dendritic spine morphologenesis in hippocampal neuron, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| Researcher : CHAN LH |
| List of Research Outputs |
| CHAN L.H. and Ma S.K.Y., PRMT6 Suppresses the Development of Hepatocellular Carcinoma via Up-regulation of ERKTFF1 Pathway, 20th Research Postgraduate Symposium. 2015. |
| Researcher : CHAUDHARY V |
| List of Research Outputs |
| CHAUDHARY V., Best Poster Award: Severe fever-with-thrombocytopenia syndrome virus NSs virulence factor is a potent suppressor of interferon production and signaling, Hong Kong Immunology Forum 2015: Annual General Meeting of the Hong Kong Society for Immunology. 2015. |
| CHAUDHARY V., ZHANG S., Yuen K.S., LI D., Kok K.H., LIANG M. and Jin D., Opposite effect of severe fever-with-thrombocytopenia syndrome virus NSs protein on type I and type II interferon signaling, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| CHAUDHARY V., Zhang S., Yuen K.S., Li C., Lui P.Y., FUNG S.Y., WANG P., Chan C.P., Li D., Kok K.H., Liang M. and Jin D., Suppression of type I and type III interferon signalling by NSs protein of severe fever-with-thrombocytopenia syndrome virus through inhibition of STAT1 phosphorylation and activation, Journal of General Virology. 2015. |
| Researcher : CHEN J |
| List of Research Outputs |
| AN L., JIANG Y., Ng H.W.H., CHEN J., GONG Q. and Huen M.S.Y., USP7 Enforces RNF169-dependent DNA Double-Strand Break Responses, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| CHEN X. and Chen J., Deletions around the F508 residue revealed the importance of regional integrity in protein processing of the cystic fibrosis transmembrane conductance regulator, 29th North American Cystic Fibrosis Conference. 2015. |
| CHEN X. and Chen J., Mutations On The Residues N505 and Y512 Disrupted Protein Processing Of The Cystic Fibrosis Transmembrane Conductance Regulator By Different Mechanisms, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| CHEN X., ZHU S., XU W. and Chen J., Regional Disturbances Around the F508 Residues Exhibited Various Impacts on The function of The Cystic Fibrosis Transmembrane Conductance Regulator, ATP-binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases. 2016. |
| CHEN X., ZHU S., XU W. and Chen J., Regional Disturbances Around the F508 Residues Exhibited Various Impacts on The function of The Cystic Fibrosis Transmembrane Conductance Regulator, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| XU W., Li N.F. and Chen J., Apical Na+ is required for decreasing transepithelial Na+ current of cultured pig tracheal epithelia by the apical Krebs solution, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| XU W., Li N.F. and Chen J., Contact-dependent virulence of P. aeruginosa is required for elevating paracellular conductance of cultured pig tracheal epithelia, 29th Annual North American Cystic Fibrosis Conference. 2015. |
| XU W., Li N.F. and Chen J., Effects of the apical Krebs solution on ion transport of cultured pig tracheal epithelia, American Thoracic Society (ATS) 2016 International Conference. 2016. |
| XU W., Li N.F. and Chen J., Effects of the apical Krebs solution on ion transport of cultured pig tracheal epithelia, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| ZHU S. and Chen J., Bacterial killing of cultured pig tracheal epithelia was not altered by HCO3−-free medium, American Thoracic Society (ATS) 2016 International Conference. 2016. |
| ZHU S., XU W., Li N.F. and Chen J., Roles of bicarbonate ion in ion transport and bacterial killing of cultured pig tracheal epithelia, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Researcher : CHEN W |
| List of Research Outputs |
| Chan Y.S., Botelho F.P., CHEN W., Ma C.W., Shi W. and Shum D.K.Y., Developmental mechanism underlying sensorimotor control of orienting behavior [Wuzhen, China. Sept. 20-23, 2015], Proc.5th FAONS Congress. 2015. |
| JIANG Q., Ma C.W., CHEN W., Shum D.K.Y. and Chan Y.S., Fluoxetine induces restoration of plasticity in the adult vestibular system [25th Meeting of International Society for Neurochemistry Cairns, Australia. Aug. 23-27, 2015], Journal of Neurochemistry. 2015. |
| Researcher : CHEN X |
| List of Research Outputs |
| CHEN X. and Chen J., Deletions around the F508 residue revealed the importance of regional integrity in protein processing of the cystic fibrosis transmembrane conductance regulator, 29th North American Cystic Fibrosis Conference. 2015. |
| CHEN X. and Chen J., Mutations On The Residues N505 and Y512 Disrupted Protein Processing Of The Cystic Fibrosis Transmembrane Conductance Regulator By Different Mechanisms, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| CHEN X., ZHU S., XU W. and Chen J., Regional Disturbances Around the F508 Residues Exhibited Various Impacts on The function of The Cystic Fibrosis Transmembrane Conductance Regulator, ATP-binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases. 2016. |
| CHEN X., ZHU S., XU W. and Chen J., Regional Disturbances Around the F508 Residues Exhibited Various Impacts on The function of The Cystic Fibrosis Transmembrane Conductance Regulator, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Researcher : CHENG SY |
| List of Research Outputs |
| CHENG S.Y., Hung H.L.C. and Chang R.C.C., Differential roles of the ubiquitin-proteasome system and autophagy in experimental models of Alzheimer’s Disease, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| Chang R.C.C., Cheng S.Y. and Hung H.L.C., Investigating protein degradation pathways in Alzheimer’s disease, International Alzheimer's Disease Conference. 2016, 24. |
| Cheng S.Y., Hung H.L.C. and Chang R.C.C., Differential roles of the ubiquitin-proteasome system and autophagy in experimental models of Alzheimer’s disease. , Annual Scientific Conference of The Hong Kong Society of Neuroscience 2016. 23. |
| Hung H.L.C., Cheng S.Y., Lee S.M.Y. and Chang R.C.C., The dynamic mitochondria network in neurodegeneration., Annual Scientific Conference of The Hong Kong Society of Neuroscience 2016. 25. |
| Hung H.L.C., Cheng S.Y., Lee S.M.Y. and Chang R.C.C., The dynamic mitochondrial network in Alzheimer’s disease, International Alzheimer’s Disease Conference 2016. 62. |
| LEUNG W.Y.Y., Ng T.W., Cheng S.Y., Hung H.L.C., Chu M.T., Chang R.C.C. and Wong G.T.C., The effect of sevoflurane in cognition. , The 11th International Conference on Healthy Aging. 2016, 71. |
| LEUNG W.Y.Y., Ng T.W., Cheng S.Y., Hung H.L.C., Chu M.T., Chang R.C.C. and Wong G.T.C., The effect of sevoflurane in cognitive and synaptic function, International Alzheimer’s Disease Conference . 2016, 64. |
| SHAH A.N., Hung H.L.C., CHENG S.Y. and Chang R.C.C., The effect of Oxyresveratrol on endoplasmic reticulum stress in Parkinson’s disease, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| SHAH A.N., Hung H.L.C., Cheng S.Y. and Chang R.C.C., The effect of oxyresveratrol on endoplasmic reticulum stress in Parkinson’s disease., Annual Scientific Conference of The Hong Kong Society of Neuroscience 2016. 50. |
| SHAH A.N., Hung H.L.C., Cheng S.Y. and Chang R.C.C., The role of oxyresveratrol in mitigating cellular toxicity in Parkinson’s disease, The 11th International Conference on Healthy Aging. 2016, 63. |
| YOU R., Cheng S.Y., Hung H.L.C., Ho Y.S., Lai S.W.C. and Chang R.C.C., Investigating the effects of silica nanoparticles on affective and cognitive behaviors and on synapse in vivo and in vitro. , International Alzheimer’s Disease Conference 2016. 64. |
| YOU R., Cheng S.Y., Hung H.L.C., Ho Y.S. and Chang R.C.C., Investigating the impact of Silica Nanoparticles on affective and cognitive behaviors, and on synapse in vivo and in vitro. , The 11th International Conference on Healthy Aging. 2016, 61. |
| Researcher : CHENG Y |
| List of Research Outputs |
| CHENG Y., GAO W., Tang H.M.V., Deng J., Wong C.M., Chan C.P. and Jin D., β-TrCP-mediated ubiquitination and degradation of liver-enriched transcription factor CREB-H, Scientific Reports. 2016, 6. |
| CHENG Y., GAO W., Tang H.M.V., Deng J., Chan C.P. and Jin D., β-TrCP-mediated ubiquitination and degradation of liver-enriched transcription, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| GAO W., Tang H.M.V., CHENG Y., Deng J., Chan C.P. and Jin D., Ubiquitination and degradation of CRTC1 transcriptional coactivator triggered by salt-inducible kinase 1-dependent phosphorylation, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Tang H.M.V., GAO W., Chan C.P., CHENG Y., Deng J., Yuen K.S., Iha H. and Jin D., SIRT1 Suppresses Human T-Cell Leukemia Virus Type 1 Transcription, Journal of Virology. 2015, 89: 8623-8631. |
| Researcher : CHOW WH |
| List of Research Outputs |
| CHOW W.H., CHAM W.C., Chan Y.S. and Shum D.K.Y., Role of Proheparanase in Regulating Synaptic Plasticity in Rat Hippocampus, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| CHOW W.H., Chan Y.S. and Shum D.K.Y., Roles of Neuronal and Astrocytic Proheparanase in Regulating Synaptic Strength in Rat Hippocampus, 11th International Symposium on Healthy Aging. 2016. |
| CHOW W.H., Chan Y.S. and Shum D.K.Y., Roles of Neuronal and Astrocytic Proheparanase in Regulating Synaptic Strength in Rat Hippocampus, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Researcher : CHU TL |
| List of Research Outputs |
| CHU T.L., Tsang K.Y., Zhou Z. and Cheah K.S.E., The role of MMP14 in lineage progression of hypertrophic chondrocytes, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Researcher : Cai S |
| Project Title: | 25TH MEETING OF THE INTERNATIONAL SOCIETY FOR NEUROCHEMISTRY (25th ISN-APSN Joint Biennial Meeting in Cairns, Australia, August 23-27, 2015, in conjunction with the Australasian Society for Neuroscience (ANS)); Small molecule approach to direct differentiation of human induced pluripotent stem cells to sensory neurons |
| Investigator(s): | Cai S |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2015 |
| Completion Date: | 08/2015 |
| List of Research Outputs |
| Cai S., Chan Y.S. and Shum D.K.Y., Derivation of stable Schwann cells from human bone marrow stromal cells [25th Meeting of International Society for Neurochemistry. Cairns, Australia. Aug. 23-27, 2015], Journal of Neurochemistry. 2015. |
| Cai S., Han L., Ao Q., Chan Y.S. and Shum D.K.Y., Induced pluripotent stem cell-derived sensory neurons for fate commitment of bone marrow-derived Schwann cells – Utilization in re-myelination therapy , Stem Cells Translational Medicine. 2016, 5: 1-13. |
| Cai S., Chan Y.S. and Shum D.K.Y., Induced pluripotent stem cell-derived sensory neurons for in vitro specification of Schwann cells with potential for re-myelination therapy [HK. March 12-13, 2016], Abstracts of 11th Int’l Symp. on Healthy Aging: Science and Aging – An Era of Discovery. 2016, 61. |
| Cai S., Chan Y.S. and Shum D.K.Y., Small molecule approach to differentiation of human induced pluripotent stem cells to sensory neurons [HK. May 18, 2016], Proc. Neuroscience Symposium 2016 & Scientific Conference of The Hong Kong Society of Neurosciences. 2016, 30. |
| Cai S., Han L., Chan Y.S. and Shum D.K.Y., Small molecule approach to differentiation of human induced pluripotent stem cells to sensory neurons, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| Shum D.K.Y., Cai S., Han L. and Chan Y.S., Small molecule approach to direct differentiation of human induced pluripotent stem cells to sensory neurons 665.18/B44. [Chicago. Oct. 15-19, 2015], Soc. Neuroscience Abstract (USA). 2015. |
| Researcher : Chan CP |
| List of Research Outputs |
| CHAUDHARY V., Zhang S., Yuen K.S., Li C., Lui P.Y., FUNG S.Y., WANG P., Chan C.P., Li D., Kok K.H., Liang M. and Jin D., Suppression of type I and type III interferon signalling by NSs protein of severe fever-with-thrombocytopenia syndrome virus through inhibition of STAT1 phosphorylation and activation, Journal of General Virology. 2015. |
| CHENG Y., GAO W., Tang H.M.V., Deng J., Wong C.M., Chan C.P. and Jin D., β-TrCP-mediated ubiquitination and degradation of liver-enriched transcription factor CREB-H, Scientific Reports. 2016, 6. |
| CHENG Y., GAO W., Tang H.M.V., Deng J., Chan C.P. and Jin D., β-TrCP-mediated ubiquitination and degradation of liver-enriched transcription, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Chan C.P., YUEN C.K., FUNG S.Y., KEW C., Yuen K.Y., Kok K.H. and Jin D., Antagonising roles between PACT and influenza A virus polymerase subunits in viral replication and innate immune response, American Association for Immunologists Annual Meeting - Immunology 2016. |
| Chan C.P., YUEN C.K., FUNG S.Y., KEW C., Zheng B., Yuen K.Y., Kok K.H. and Jin D., Influenza A virus NS1 protein targets double stranded RNA-binding protein PACT to suppress innate antiviral response , 10th Asia-Pacific Congress of Medical Virology 2015. |
| GAO W., Tang H.M.V., CHENG Y., Deng J., Chan C.P. and Jin D., Ubiquitination and degradation of CRTC1 transcriptional coactivator triggered by salt-inducible kinase 1-dependent phosphorylation, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| HO T.H., KEW C., LUI P.Y., Chan C.P., Satoh T., Akira S., Jin D. and Kok K.H., PACT- and RIG-I-Dependent Activation of Type I Interferon Production by a Defective Interfering RNA Derived from Measles Virus Vaccine, Journal of Virology. 2016, 90: 1557-1568. |
| Jin D., Tang H.M.V., GAO W., Chan C.P., Iha H. and Yuen K.S., Suppression of HTLV-1 transcription by SIRT1 deacetylase, Retrovirology. 2015, 12: P53. |
| Lui P.Y., WONG L.Y.R., Fung C.L., Siu K.L., Yeung M.L., Yuen K.S., Chan C.P., Woo P.C.Y., Yuen K.Y. and Jin D., Middle East respiratory syndrome coronavirus M protein suppresses type I interferon expression through the inhibition of TBK1-dependent phosphorylation of IRF3, Emerging Microbes & Infections. 2016, 5: e39. |
| Tang H.M.V., GAO W., Chan C.P., CHENG Y., Deng J., Yuen K.S., Iha H. and Jin D., SIRT1 Suppresses Human T-Cell Leukemia Virus Type 1 Transcription, Journal of Virology. 2015, 89: 8623-8631. |
| Wong L.W.M., YUEN C.K., Chan C.P., Jin D. and Kok K.H., Mutual Antagonism Between Pact And Influenza A Virus Polymerase Subunits Regulates Viral Replication And Interferon Production., American Society For Virology. 2016. |
| YUEN C.K., Chan C.P., FUNG S.Y., WANG P., Wong L.W.M., Tang H.M.V., Yuen K.S., Chan C.P., Jin D. and Kok K.H., Suppression of Type I Interferon Production by Human T-Cell Leukemia Virus Type 1 Oncoprotein Tax through Inhibition of IRF3 Phosphorylation, Journal of Virology. 2016, 90: 3902-3912. |
| Researcher : Chan CP |
| Project Title: | Roles of liver-enriched transcription factor CREB-H in liver fibrosis |
| Investigator(s): | Chan CP, Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2014 |
| Completion Date: | 07/2015 |
| Project Title: | Regulation of hepatitis B virus transcription by PRMT5 protein arginine methyltransferase |
| Investigator(s): | Chan CP, Zhou J |
| Department: | Biochemistry |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 08/2015 |
| Project Title: | Characterization of a novel b-TrCP ubiquitin ligase-dependent mechanism for ubiquitination and degradation of liver-enriched transcription factor CREB-H |
| Investigator(s): | Chan CP, Yuen KS, Lui PY |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - Science Fund for Young Scholars |
| Start Date: | 01/2016 |
| Project Title: | Antiviral activity of cGAS/cGAMP against RNA virus infection |
| Investigator(s): | Chan CP |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2016 |
| Project Title: | The American Association of Immunologists annual meeting 2016; Antagonising roles between PACT and influenza A virus polymerase subunits in viral replication and innate immune response |
| Investigator(s): | Chan CP |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2016 |
| Completion Date: | 05/2016 |
| List of Research Outputs |
| CHAUDHARY V., Zhang S., Yuen K.S., Li C., Lui P.Y., FUNG S.Y., WANG P., Chan C.P., Li D., Kok K.H., Liang M. and Jin D., Suppression of type I and type III interferon signalling by NSs protein of severe fever-with-thrombocytopenia syndrome virus through inhibition of STAT1 phosphorylation and activation, Journal of General Virology. 2015. |
| CHENG Y., GAO W., Tang H.M.V., Deng J., Wong C.M., Chan C.P. and Jin D., β-TrCP-mediated ubiquitination and degradation of liver-enriched transcription factor CREB-H, Scientific Reports. 2016, 6. |
| CHENG Y., GAO W., Tang H.M.V., Deng J., Chan C.P. and Jin D., β-TrCP-mediated ubiquitination and degradation of liver-enriched transcription, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Chan C.P., YUEN C.K., FUNG S.Y., KEW C., Yuen K.Y., Kok K.H. and Jin D., Antagonising roles between PACT and influenza A virus polymerase subunits in viral replication and innate immune response, American Association for Immunologists Annual Meeting - Immunology 2016. |
| Chan C.P., YUEN C.K., FUNG S.Y., KEW C., Zheng B., Yuen K.Y., Kok K.H. and Jin D., Influenza A virus NS1 protein targets double stranded RNA-binding protein PACT to suppress innate antiviral response , 10th Asia-Pacific Congress of Medical Virology 2015. |
| GAO W., Tang H.M.V., CHENG Y., Deng J., Chan C.P. and Jin D., Ubiquitination and degradation of CRTC1 transcriptional coactivator triggered by salt-inducible kinase 1-dependent phosphorylation, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| HO T.H., KEW C., LUI P.Y., Chan C.P., Satoh T., Akira S., Jin D. and Kok K.H., PACT- and RIG-I-Dependent Activation of Type I Interferon Production by a Defective Interfering RNA Derived from Measles Virus Vaccine, Journal of Virology. 2016, 90: 1557-1568. |
| Jin D., Tang H.M.V., GAO W., Chan C.P., Iha H. and Yuen K.S., Suppression of HTLV-1 transcription by SIRT1 deacetylase, Retrovirology. 2015, 12: P53. |
| Lui P.Y., WONG L.Y.R., Fung C.L., Siu K.L., Yeung M.L., Yuen K.S., Chan C.P., Woo P.C.Y., Yuen K.Y. and Jin D., Middle East respiratory syndrome coronavirus M protein suppresses type I interferon expression through the inhibition of TBK1-dependent phosphorylation of IRF3, Emerging Microbes & Infections. 2016, 5: e39. |
| Tang H.M.V., GAO W., Chan C.P., CHENG Y., Deng J., Yuen K.S., Iha H. and Jin D., SIRT1 Suppresses Human T-Cell Leukemia Virus Type 1 Transcription, Journal of Virology. 2015, 89: 8623-8631. |
| Wong L.W.M., YUEN C.K., Chan C.P., Jin D. and Kok K.H., Mutual Antagonism Between Pact And Influenza A Virus Polymerase Subunits Regulates Viral Replication And Interferon Production., American Society For Virology. 2016. |
| YUEN C.K., Chan C.P., FUNG S.Y., WANG P., Wong L.W.M., Tang H.M.V., Yuen K.S., Chan C.P., Jin D. and Kok K.H., Suppression of Type I Interferon Production by Human T-Cell Leukemia Virus Type 1 Oncoprotein Tax through Inhibition of IRF3 Phosphorylation, Journal of Virology. 2016, 90: 3902-3912. |
| Researcher : Chan CWY |
| Project Title: | Human embryonic stem cell-derived cardiomyocyte as a model to study the role of autophagy in cardiac inflammation |
| Investigator(s): | Chan CWY, Li RA |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 11/2013 |
| Completion Date: | 11/2016 |
| List of Research Outputs |
| YAO H., Jin J., Wong K.Y.G. and Chan C.W.Y., Oxidative Stress Induces Autophagy in Human Embryonic Stem Cell-derived Cardiomyocytes (hESC-CMs), 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Researcher : Chan D |
| Project Title: | Genome-wide identification and functional studies of genetic risk factors for low back pain and intervertebral disc degeneration |
| Investigator(s): | Chan D |
| Department: | Biochemistry |
| Source(s) of Funding: | AOSpine International - General Award |
| Start Date: | 08/2007 |
| Project Title: | Research Output Prize (Li Ka Shing Faculty of Medicine) |
| Investigator(s): | Chan D |
| Department: | Biochemistry |
| Source(s) of Funding: | Research Output Prize (in Faculty) |
| Start Date: | 12/2010 |
| Project Title: | Interplay between ER stress and hypoxic stress in the regulation of chondrocyte differentiation |
| Investigator(s): | Chan D, Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2012 |
| Project Title: | Integrative Approaches to Understanding Disorders of the Skeleton |
| Investigator(s): | Chan D |
| Department: | Biochemistry |
| Source(s) of Funding: | Croucher Advanced Study Institute |
| Start Date: | 12/2013 |
| Project Title: | Progenitor cells in the formation and repair of articular cartilage |
| Investigator(s): | Chan D, Cheah KSE, Chan BP |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Project Title: | Genetic and cellular basis of protective/regenerative mechanisms in skeletal tissues |
| Investigator(s): | Chan D |
| Department: | Biochemistry |
| Source(s) of Funding: | Croucher Senior Research Fellowships in Natural Sciences, Technology and Medicine |
| Start Date: | 08/2014 |
| Completion Date: | 07/2015 |
| Project Title: | Mechanisms of energy management in hypertrophic chondrocyte adaptation to ER Stress |
| Investigator(s): | Chan D, Chan BP, Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Cellular changes in spinal curvature from FGFR3 mutations and response to drug treatment |
| Investigator(s): | Chan D, To MKT |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | France/Hong Kong Joint Research Scheme - Travel Grants |
| Start Date: | 01/2016 |
| List of Research Outputs |
| Cheah K.S.E., Au Y.K., Wynn S., Tan T., YIP K.H.R. and Chan D., Genetic control of hypertrophic chondrocyte to osteoblast differentiation in development and skeletal disorders, American Association of Anatomists (AAA) 2016 Annual Meeting. 2016. |
| Cheah K.S.E., Au Y.K., Wynn S., Tan T., YIP K.H.R. and Chan D., Genetic control of hypertrophic chondrocyte to osteoblast differentiation in development and skeletal disorders, American Association of Anatomists (AAA) 2016 Annual Meeting, San Diego, USA, April 2-6, 2016.. 2016. |
| Cheah K.S.E., Au Y.K., Niu B., Chan D. and Zhang M.Q., SPINE-GEL: a global gene expression library for the developing nucleus pulposus., Spine Week, Singapore, May 16-20, 2016. |
| Kudelko M.A., Sharma R., Cheah K.S.E. and Chan D., Comparison of proteomic datasets from hypertrophic chondrocytes in response to ER stress, Data Brief. 2016, 7: 449-51. |
| LI H.Y., CHOOI W.H., Chan D., Cheah K.S.E. and Chan B.P., Development of protein-based 3D culture system for bovine nucleus pulposus cells., TERMIS 4th World Congress. Boston, USA. 5-9 Sep 2015. |
| LI Y., Samartzis D., Campbell D.D., Cherny S.S., Cheung K.M.C., Luk K.D.K., Karppinen J., Song Y., Cheah K.S.E., Chan D. and Sham P.C., Two subtypes of intervertebral disc degeneration distinguished by large-scale population-based study, The Spine Journal. 2016, pii: S1529-9430(16)30095-X. |
| LIM F.L., ZHANG C., Tam W.K., Au Y.K., Chan D., Tuan R.S., Cheah K.S.E., Cheung K.M.C. and Leung V.Y.L., Nucleus Pulposus Cell Vacuolation: A New Perspective From N-Cadherin/Cadherin 2 Function, ORS 3rd International Spine Research Symposium, Philadelphia, USA . 2015. |
| MA S.K.Y., SHEN S., Ng V.C.W., An Y., Agata K., Lam Y.W. and Chan D., Phylogenetic Analysis of Planarian Collagens and their Roles in Regeneration, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| SHAH A.M., Chan W.C.W. and Chan D., The Role of Hypertrophic Chondrocytes and Cellular Stress in Intervertebral Disc Integrity and Degeneration, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Tam V., Solis N., Overall C., Klein T., Cheung K.M.C., Cheah K.S.E. and Chan D., Degradome of the Intervertebral Disc, Global Spine Congress / World Forum for Spine Research. 2016. |
| Tsang K.Y., Wu M.H., Zhang M., Gu J., Yu X. and Chan D., Dissecting the transition from hypertrophic chondrocyte to osteoblast in skeletal development and growth, Gordon Research Conference on Bones & Teeth, Galveston, TX, USA, February 14-19, 2016. |
| Tsang K.Y., Wu M.H., Zhang M., Gu J., Yu X., Chan D. and Cheah K.S.E., Dissecting the transition from hypertrophic chondrocyte to osteoblast in skeletal development and growth, Gordon Research Conference – Bones & Teeth, Galveston, TX, USA, February 14-19, 2016. |
| Tsang K.Y., Chan W.C.W., Cheng Y.W., Chik H., Boot-Handford R.P., Boyde, A.J.S., Cheung K.M.C. and Cheah K.S.E., Chan D., Pathological ER stress impairs osteocyte maturation causing hyperostosis in mice., Gordon Research Conference- Stress Proteins in Growth, Development & Disease, Italy, July 5-10, 2015. |
| Tsang K.Y., Chan W.C.W., Cheng Y.W., Chik H., Boot-Handford R.P., Boyde A., Jones S.H.E.I.L.A., Cheung K.M.C., Cheah K.S.E. and Chan D., Pathological ER stress impairs osteocyte maturation causing hyperostosis in mice, Gordon Research Conference on Stress Proteins in Growth, Development & Disease. 2015. |
| Tsang K.Y., Li X., Gu J., Chan D., Zhang M.Q. and Cheah K.S.E., Reconstructing the chondro-osteoblastic lineage by single cell RNA-seq, Single Cell Biology, 8-10 March 2016, Wellcome Genome Campus, Hinxton, Cambridge, UK. 2016. |
| Tsang K.Y., Chan D. and Cheah K.S.E., Wiley Blackwell Prize 2016, In: Harukazu Nakamura, Development, Growth & Differentiation, John Wiley & Sons, Inc.. 2016. |
| Wang A.M., Leung G.K.K., KIANG M.Y., Chan D., Cao P. and Wu E.X., Separation and quantification of lactate and lipid at 1.3 ppm by diffusion-weighted magnetic resonance spectroscopy, Magnetic Resonance in Medicine. 2016, Epub on 2016-02-01. |
| Wang C., Tan Z., Tsang K.Y., Ron D., Itoh N., Chan D. and Cheah K.S.E., The PERK pathway attenuates ER stress in hypertrophic chondrocyte via Sox9 and FGF21., Gordon Research Conference- Stress Proteins in Growth, Development & Disease, Italy, July 5-10, 2015. |
| XIONG C., LI Y., RAI F.M., SANDELL L., ZHANG Y., Song Y., Cheah K.S.E., Sham P.C. and Chan D., Genetic contribution to degeneration and repair potentials of the intervertebral disc in mice, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| XIONG C., LI Y., Rai F.M., Sham P.C., ZHANG Y., Song Y., Cheah K.S.E. and Chan D., Genetic contribution to intervertebral discs integrity maintenance in mouse model, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| YIP K.H.R., Au Y.K., Chan D. and Cheah K.S.E., Investigating molecular pathogenesis of Campomelic Dysplasia, 2016 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| YIP K.H.R., Au Y.K., Chan D. and Cheah K.S.E., Investigating molecular pathogenesis of Campomelic Dysplasia, 2016 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, The Chinese University of Hong Kong, June 11, 2016. |
| YIP K.H.R., Au Y.K., Chan D. and Cheah K.S.E., Investigating molecular pathogenesis of Campomelic Dysplasia, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Yee A., Lam P.Y., Tam V., Chan W.C.W., Chu I.K., Cheah K.S.E., Cheung K.M.C. and Chan D., Fibrotic-like changes in degenerate human intervertebral discs revealed by quantitative proteomic analysis, Osteoarthritis and Cartilage. 2016, 24: 503-513. |
| Researcher : Chan LK |
| Project Title: | Perception by LKS Faculty of Medicine graduates on their university education |
| Investigator(s): | Chan LK, Ip MSM, Patil NG, Prosser MT |
| Department: | Bau Institute of Medical and Health Scie |
| Source(s) of Funding: | Teaching Development Grants |
| Start Date: | 06/2008 |
| Project Title: | Identifying the English language and communicative demands of bedside learning on students in the clinical years |
| Investigator(s): | Chan LK, Tse LK, Storey AM |
| Department: | Bau Institute of Medical and Health Scie |
| Source(s) of Funding: | Medical Faculty Research Grant Fund |
| Start Date: | 06/2008 |
| Project Title: | Assessing competency of dental graduates from problem-based learning and traditional curriculums: Graduates’ and Employers’ Perceptions |
| Investigator(s): | Chan LK, Yiu CKY, Botelho MG, Bridges SM, Corbet EF, Dyson JE, McGrath CPJ, Wong RWK, Prosser MT |
| Department: | Bau Institute of Medical and Health Scie |
| Source(s) of Funding: | Teaching Development Grants |
| Start Date: | 12/2008 |
| Project Title: | Designing technology-rich environments for case-based instruction: a model for life-long learning |
| Investigator(s): | Chan LK, Lu J |
| Department: | Bau Institute of Medical and Health Scie |
| Source(s) of Funding: | International Opportunities Fund |
| Start Date: | 03/2010 |
| Project Title: | Development of a fit-for-purpose Chinese-language course for the medical students |
| Investigator(s): | Chan LK, Soo YC, Tse SK |
| Department: | Bau Institute of Medical and Health Scie |
| Source(s) of Funding: | Faculty Development Fund of Faculty of Medicine |
| Start Date: | 06/2011 |
| Project Title: | The use of mobile devices in problem-based learning |
| Investigator(s): | Chan LK, Bridges SM, Doherty I, Jin J, Ng ML |
| Department: | Bau Institute of Medical and Health Scie |
| Source(s) of Funding: | Teaching Development Grants |
| Start Date: | 07/2013 |
| List of Research Outputs |
| Bridges S.M., Chan L.K. and Hmelo-Silver C., Educational technologies in Medical and Health Sciences Education. Springer, 2015. |
| Bridges S.M., Hmelo-Silver C. and Chan L.K., Situated Learning and Educational Technologies: Theory and practice, Educational Technologies in Medical and Health Sciences Education. Springer, 2015, 1-6. |
| Chan L.K., An electronic platform for facilitating interprofessional team-based learning (IPTBL), The 6th Annual Digital Medicine Academic Meeting of Chinese Medical Association and The 1st International Conference of Digital Medicine & Medical 3D Printing. 17-19 June 2016, Nanjing, China. 2016. |
| Chan L.K., Chen J.Y. and Chung W.S.E., Dissecting the Meaning of Life: An Anthology of Essays on Body Donation, 2015. |
| Chan L.K., Interprofessional learning for health professional students, BMJ Forum. 2015. |
| Chan L.K. and Ganotice F.J.A., Interprofessional team-based learning checklist: Development and psychometric testing, Frontiers in Medical and Health Sciences Education. 2015. |
| Chan L.K., Life and dealth education through the HKU Body Donation Programme, Life and Death Culture Week 2015-Memento Mori, Seoul. 2015. |
| Chan L.K., Principles of PBL and organization of PBL programs, Problem-based learning programme for Academic Visitors from Shanghai University of Medicine and Health Sciences (SIHS), organized by the Department of Ophthalmology & Visual Sciences, the Chinese University of Hong Kong. 2016. |
| Chan L.K. and Ganotice F.J.A., The time for Interprofessional Team-based Learning (IPTBL) in Hong Kong: A baseline study, Frontiers in Medical and Health Sciences Education. 2015. |
| Chan L.K., Training Clinical Specialists to be Teachers, Invited speaker in Medical Education Conference (MEC) 2016, organized by the Hong Kong Academy of Medicine. 2016. |
| Chan L.K., Training Clinicians to Teach, Invited speaker at QEH Department of Paediatrics. 2016. |
| Chan L.K., 大體大得—首本蒐集香港遺體捐贈相關親身經歷和珍貴回憶的文字記錄, Invited speaker in 「中文寫作‧口述歷史及社區參與」教育論壇, organized by HK Institute of Education, Literature and Cultural Studies. 2016. |
| Hmelo-Silver C., Lajoie S., Lu J., Wiseman J. and Chan L.K., Video as Context and Conduit for Problem-based Learning, Educational technologies in Medical and Health Sciences Education. 2015, 215-234. |
| Ho J.W.Y., Kwok D., Yao K.M., Chan L.K. and Ho J., Breathing life into the concepts of biochemistry – From bedside to benchside, Frontiers in Medical and Health Sciences Education. 2015. |
| Ho J.W.Y., Yao K.M., Song Y., Chan L.K., Cook S. and Bridges S.M., Teaching Development Grant, The University Of Hong Kong. 2015. |
| Hui W.H.R., Cheung L.C., Chu W.M., Fong C.Y., Lau H.W.I., Leung C.Y., Leung E., Leung S.N.S., Yip K.K.Y., Yung V.Q., Chen K. and Chan L.K., Preclinical medical students’ usage of mobile devices in lectures, a cross sectional study on usage pattern and factors affecting usage, Frontiers in Medical and Health Sciences Education. 2015. |
| Jin J., Bridges S.M. and Chan L.K., Understanding undergraduate health sciences students’ well-being in Asia: A qualitative study, Frontiers in Medical and Health Sciences Education. 2015. |
| Lajoie S., Lee L., Poitras E., Bassiri M., Kazemitabar M., Cruz-Panesso I., Hmelo-Silver C., Wiseman J., Chan L.K. and Lu J., The role of regulation in medical student learning in small groups: Regulating oneself and others' learning and emotions, Computers in Human Behavior . 2015, 52: 601-616. |
| Lui S.F., Berwick D., Chan L.K., Chau J., Chau P., Ganotice F.J.A., Lau W.C.S., Lee V., Leung A., Leung G.K.K., Perlo J., So H.Y., Strang C., Sun D.A.V.I.D., Tam I., Wong E. and Wong M., A novel way to engage healthcare students to explore patient safety – An inter-professional, interactive, experiential learning experience workshop, International Forum on Quality and Safety in Healthcare 2016 . 2016. |
| Lui T.H. and Chan L.K., The safety of the posterior ankle arthroscopy in management of posterior ankle impingement: a cadaveric study, The Foot. 2016, 27: 4-9. |
| Researcher : Chan WCW |
| Project Title: | Understanding the Differentiation of Inner Annulus Fibrosus Cells: An in vitro Approach |
| Investigator(s): | Chan WCW, Chan D |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2015 |
| Project Title: | Global Spine Congress/ World Forum for Spine Research 2016; Contribution of Hypertrophic Chondrocytes to the Homeostasis of Annulus Fibrosis in normal and degenerative intervertebral discs |
| Investigator(s): | Chan WCW |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2016 |
| Completion Date: | 04/2016 |
| List of Research Outputs |
| SHAH A.M., Chan W.C.W. and Chan D., The Role of Hypertrophic Chondrocytes and Cellular Stress in Intervertebral Disc Integrity and Degeneration, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Tsang K.Y., Chan W.C.W., Cheng Y.W., Chik H., Boot-Handford R.P., Boyde, A.J.S., Cheung K.M.C. and Cheah K.S.E., Chan D., Pathological ER stress impairs osteocyte maturation causing hyperostosis in mice., Gordon Research Conference- Stress Proteins in Growth, Development & Disease, Italy, July 5-10, 2015. |
| Tsang K.Y., Chan W.C.W., Cheng Y.W., Chik H., Boot-Handford R.P., Boyde A., Jones S.H.E.I.L.A., Cheung K.M.C., Cheah K.S.E. and Chan D., Pathological ER stress impairs osteocyte maturation causing hyperostosis in mice, Gordon Research Conference on Stress Proteins in Growth, Development & Disease. 2015. |
| Yee A., Lam P.Y., Tam V., Chan W.C.W., Chu I.K., Cheah K.S.E., Cheung K.M.C. and Chan D., Fibrotic-like changes in degenerate human intervertebral discs revealed by quantitative proteomic analysis, Osteoarthritis and Cartilage. 2016, 24: 503-513. |
| Researcher : Chan YS |
| Project Title: | 30th Annual Conference of Society for Neuroscience Expression of N-Methyl-D-Aspartate Receptor Subunits and Induction of c-fos in Otolith Neurons in the Vestibular Nuclei of Postnatal Rats |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2000 |
| Project Title: | 31st Annual Meeting of Society for Neuroscience Expression of Neurotrophin Receptors in Vestibular Nuclei During the Postnatal Development of the Rat |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2001 |
| Project Title: | XXIV Annual Conference of Indian Academy of Neurosciences Development Refinement of Spatial Recognition Circuits |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 12/2006 |
| Project Title: | Role of the thalamus in integrating spatial information and guiding navigation |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2009 |
| Project Title: | Outstanding Research Student Supervisor Award 2009-10 |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | Outstanding Research Student Supervisor Award |
| Start Date: | 12/2010 |
| Project Title: | Long-term depression of inhibitory responses is critical to the maturation of the vestibular circuitry |
| Investigator(s): | Chan YS, Shum DKY |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2012 |
| Project Title: | Serotonin-induced bidirectional modulation of activity-dependent synaptic plasticity tunes vestibular functions |
| Investigator(s): | Chan YS, Shum DKY |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2013 |
| Project Title: | Orexin-induced modulation of activity-dependent synaptic plasticity is critical for the maturation of vestibular circuitry and functions |
| Investigator(s): | Chan YS, Shum DKY, Lai CH |
| Department: | Physiology |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2015 |
| Project Title: | International Society for Neuroschemistry 2015 Biennial Conference; Fluoxetine induces restoration of plasticity in the adult vestibular system |
| Investigator(s): | Chan YS |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2015 |
| Completion Date: | 08/2015 |
| Project Title: | Semaphorin and perineuronal nets regulate developmental plasticity of central vestibular circuitry |
| Investigator(s): | Chan YS, Shum DKY |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2015 |
| Project Title: | Remodeling the sulfation pattern of perineuronal nets in the entorhinal cortical circuit prevents stress-induced decline in learning and memory |
| Investigator(s): | Chan YS, Lai SWC, Shum DKY |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2016 |
| Project Title: | Neuronal Mechanism of Cholecystokinin-Facilitated Cross-modal Learning and Memory |
| Investigator(s): | Chan YS |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 06/2016 |
| List of Research Outputs |
| CHOW W.H., CHAM W.C., Chan Y.S. and Shum D.K.Y., Role of Proheparanase in Regulating Synaptic Plasticity in Rat Hippocampus, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| CHOW W.H., Chan Y.S. and Shum D.K.Y., Roles of Neuronal and Astrocytic Proheparanase in Regulating Synaptic Strength in Rat Hippocampus, 11th International Symposium on Healthy Aging. 2016. |
| CHOW W.H., Chan Y.S. and Shum D.K.Y., Roles of Neuronal and Astrocytic Proheparanase in Regulating Synaptic Strength in Rat Hippocampus, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Cai S., Chan Y.S. and Shum D.K.Y., Derivation of stable Schwann cells from human bone marrow stromal cells [25th Meeting of International Society for Neurochemistry. Cairns, Australia. Aug. 23-27, 2015], Journal of Neurochemistry. 2015. |
| Cai S., Han L., Ao Q., Chan Y.S. and Shum D.K.Y., Induced pluripotent stem cell-derived sensory neurons for fate commitment of bone marrow-derived Schwann cells – Utilization in re-myelination therapy , Stem Cells Translational Medicine. 2016, 5: 1-13. |
| Cai S., Chan Y.S. and Shum D.K.Y., Induced pluripotent stem cell-derived sensory neurons for in vitro specification of Schwann cells with potential for re-myelination therapy [HK. March 12-13, 2016], Abstracts of 11th Int’l Symp. on Healthy Aging: Science and Aging – An Era of Discovery. 2016, 61. |
| Cai S., Chan Y.S. and Shum D.K.Y., Small molecule approach to differentiation of human induced pluripotent stem cells to sensory neurons [HK. May 18, 2016], Proc. Neuroscience Symposium 2016 & Scientific Conference of The Hong Kong Society of Neurosciences. 2016, 30. |
| Cai S., Han L., Chan Y.S. and Shum D.K.Y., Small molecule approach to differentiation of human induced pluripotent stem cells to sensory neurons, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| Chan R.W., Leong A.T., Gao P.P., Fan S.J., Chan Y.S., Yung W.H., Tsia K.K. and Wu E.X., Low frequency stimulation of hippocampus evoked large-scale cortical and subcortical responses: An optogenetic functional MRI study 449.18/DD18. [Chicago. Oct. 15-19, 2015], Soc. Neuroscience Abstract (USA). 2015. |
| Chan Y.S., Cellular correlates of developmental plasticity in spatial coding [Bangkok. Nov. 22-25, 2015], Proc. 8th Congress of FAOPS. 2015. |
| Chan Y.S., Combining humanities and ethics curriculum in order to enhance professionalism in practice among medical students at HKU, [15th Medical Education Conference for China Mainland, Taiwan and the Hong Kong Region. Beijing. Oct. 31 – Nov. 1, 2015]. 2015. |
| Chan Y.S., Botelho F.P., CHEN W., Ma C.W., Shi W. and Shum D.K.Y., Developmental mechanism underlying sensorimotor control of orienting behavior [Wuzhen, China. Sept. 20-23, 2015], Proc.5th FAONS Congress. 2015. |
| Chan Y.S., Developmental mechanism underlying sensorimotor control of orienting behavior, [6th Congress of Federation of Asian-Oceanian Neuroscience Societies. Wuzhen, China. Sept. 20-23, 2015]. 2015. |
| Chan Y.S., Developmental plasticity of neural circuitry for spatial coding, [8th Congress of Federation of Asian-Oceanian Physiological Societies. Bangkok, Thailand. Nov. 22-25, 2015]. 2015. |
| Chan Y.S., IBRO Reports (Editor-in-Chief), Elsevier (Amsterdam, The Netherlands), 2015. |
| Chan Y.S., Han L., Li Y.H., Ma C.W. and Shum D.K.Y., Role of G-protein-coupled serotonin receptor on synaptic plasticity of excitatory transmission in the vestibular nucleus of rats ( USA) 236.03/L22 [Chicago. Oct. 15-19, 2015], Soc. Neuroscience Abstract. 2015. |
| Chan Y.S. and Lai C.H., The Vestibular System: Our Sense of Balance, Human Physiology. 2015, 22: 706-719. |
| Chen C.W., Ma C.W., Botelho F.P., Lai C.H., Shum D.K.Y. and Chan Y.S., Early postnatal perturbation of GABAergic transmission the vestibular nucleus impacts on the spatial map and spatial navigation behaviors [Kobe, Japan. July 28-31, 2015] 2004-1-4, Proc. 38th Annual Meeting of Japan Neuroscience Society. 2015. |
| Chow G.H., Cham W.C., Chan Y.S. and Shum D.K.Y., Role of proheparanase in regulating synaptic plasticity in rat hippocampus [Seoul, Korea. Aug. 23-27, 2015], Proc. 9th International Conference on Proteoglycans & 10th Pan-Pacific Connective Tissue Societies Symposium. 2015. |
| Chow W.H., Cham W.C., Chan Y.S. and Shum D.K.Y., Role of neuronal and astrocytic proheparanase in regulating synaptic strength in rat hippocampus [HK. March 12-13, 2016], Abstracts of 11th Int’l Symp. on Healthy Aging: Science and Aging – An Era of Discovery. 2016, 69. |
| DUAN Z., Fung M.L., Ni Y., Wu W., Chan Y.S. and Huang J., Kinesin-1 regulates extrasynaptic NMDAR targeting and its reduction can confer neuroprotection, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| HAU W.F., Chan Y.S. and Shum D.K.Y., Change in sulfation patterns of chondroitin associated with the plastic changes in the rat brainstem [HK. March 12-13, 2016], Abstracts of 11th Int’l Symp. on Healthy Aging: Science and Aging – An Era of Discovery. 2016, 68. |
| HAU W.F., Chan Y.S. and Shum D.K.Y., Differential sulfation of chondroitins in the brain extracellular matrix regulates neuroplasticity, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| HAU W.F., Chan Y.S. and Shum D.K.Y., Dynamics of chondroitin sulfation in the rat brain during development and vestibular compensation, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| Han L., Yanagawa Y., Lai S.W.C. and Chan Y.S., Manipulation of different cortical neuron subtypes with optogenetics [HK. May 18, 2016], Proc. Neuroscience Symposium 2016 & Scientific Conference of The Hong Kong Society of Neurosciences. 2016, 34. |
| Han L., Yanagawa Y., Lai S.W.C. and Chan Y.S., Manipulation of different cortical neuron subtypes with optogenetics, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| Han L., Yanagawa Y. and Chan Y.S., Selective expression of functional light-gated ion channel in neural circuits [HK. March 12-13, 2016], Abstracts of 11th Int’l Symp. on Healthy Aging: Science and Aging – An Era of Discovery. 2016, 71. |
| JIANG Q., Shum D.K.Y. and Chan Y.S., Antidepressant re-opens the plasticity of vestibular-mediated navigation in the adult, Abstracts of 11th Int’l Symp. on Healthy Aging: Science and Aging – An Era of Discovery. 2016, 48. |
| JIANG Q., Shum D.K.Y. and Chan Y.S., Antidepressant reinstates the plasticity in the adult vestibular nucleus, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| JIANG Q., Ma C.W., Chen C.W., Shum D.K.Y. and Chan Y.S., Fluoxetine induces rejuvenation of plasticity in the vestibular system of adult rats IP106. [Kobe, Japan. July 28-31, 2015], Proc. 38th Annual Meeting of Japan Neuroscience Society. 2015. |
| JIANG Q., Ma C.W., CHEN W., Shum D.K.Y. and Chan Y.S., Fluoxetine induces restoration of plasticity in the adult vestibular system [25th Meeting of International Society for Neurochemistry Cairns, Australia. Aug. 23-27, 2015], Journal of Neurochemistry. 2015. |
| JIANG Q. and Chan Y.S., Sun Chieh Yeh Young Investigator Award to Qiu-Fen Jiang (Oral Category), 11th International Symposium on Healthy Aging [HK March 2016]. 2016. |
| JIANG Y., Ma C.W., Wang J.J. and Chan Y.S., Orexin modulates inhibitory synaptic transmission of vestibular nuclear neurons in rats [HK. May 18, 2016], Proc. Neuroscience Symposium 2016 & Scientific Conference of The Hong Kong Society of Neurosciences. 2016, 37. |
| JIANG Y., Ma C.W., Wang J.J. and Chan Y.S., Orexin modulates inhibitory synaptic transmission of vestibular nuclear neurons in rats, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Role of perineuronal chondroitin sulfates and semaphorin 3A in the maturation of the vestibular circuitry [HK. March 12-13, 2016], Abstracts of 11th Int’l Symp. on Healthy Aging: Science and Aging – An Era of Discovery. 2016, 70. |
| KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Roles of perineuronal chondroitin sulfates and semaphorin 3A in the maturation of the vestibular circuitry, Abstracts of 11th Int’l Symp. on Healthy Aging: 70. 2016. |
| KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., The Regulatory Roles of Semaphorin 3A and Chondroitin Sulfates on Perineuronal Nets in the Developing Vestibular Circuitry, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., The Roles of Semaphorin 3A and Chondroitin Sulfates on Perineuronal Nets in Regulating the Development of Vestibular Circuitry, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Combination of uniaxial chitosan nanofibers and immobilized chondroitinase ABC improves axonal regrowth in vitro, 11st International Symposium on Healthy Aging: Science and Aging: An Era of Discovery. 2016. |
| Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Combination of uniaxial chitosan nanofibers and immobilized chondroitinase ABS improves axonal regrowth in vitro [HK. March 12-13, 2016], Abstracts of 11th Int’l Symp. on Healthy Aging: Science and Aging – An Era of Discovery. 2016, 60. |
| LAM T.F., JIANG Q. and Chan Y.S., Developmental Roles of Orexin in the Central Vestibular System on Acquisition of Motor Coordination and Spatial Recognition, 11th International Symposium on Healthy Aging. 2016. |
| LAM T.F. and Chan Y.S., Modulatory Effects of Orexin on the Functional Maturation of Central Vestibular System in Motor Coordination and Spatial Recognition, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| LAM T.F. and Chan Y.S., Role of Orexin in Functional Maturation of Central Vestibular System in Motor Coordination and Spatial Recognition, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| LI Z., Lam Y.L., Cham C.W., Ma C.W., Chan Y.S. and Shum D.K.Y., Axonal trafficking and localized trafficking of heparanase 1 [HK. March 12-13, 2016], Abstracts of 11th Int’l Symp. on Healthy Aging: Science and Aging – An Era of Discovery. 2016, 60. |
| LI Z., LAM Y.L., CHAM W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Axonal trafficking and localized trafficking of heparanase 1, Abstracts of 11th Int’l Symp. on Healthy Aging: 60. 2016. |
| LI Z., Ma C.W., Chan Y.S. and Shum D.K.Y., Axonal trafficking of heparanase 1, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| Lam U.T.F., JIANG Q. and Chan Y.S., Developmental roles of orexin in the central vestibular system on acquisition of motor coordination and spatial recognition [HK. March 12-13, 2016], Abstracts of 11th Int’l Symp. on Healthy Aging: Science and Aging – An Era of Discovery. 2016, 60. |
| Leong A.T., Chan R.W., Cao P., FAN S., Chan Y.S., Yung W.H., Tsia K.K. and Wu E.X., Optogenetic fMRI investigation of the spatiotemporal characteristics of the somatosensory thalamocortical circuit 449.18/DD17. [Chicago. Oct. 15-19, 2015], Soc. Neuroscience Abstract (USA) . 2015. |
| Mun K.L., Tsui Y.P., Tai E.W., Chan Y.S., Shum D.K.Y. and Shea G.K.H., Rapid and efficient generation of neural progenitors from adult bone marrow stromal cells by hypoxic preconditioning, Stem Cells Research &Therapy. 2016, D16-00202. |
| Shea G.K.H., Tsui Y.P., Mung K.L., Chan Y.S. and Shum D.K.Y., Rapid and efficient generation of neural progenitors from adult bone marrow stromal cells by hypoxic preconditioning, International Society for Stem Cell Research 2016. |
| Shum D.K.Y., HAU W.F., Ma C.W. and Chan Y.S., Modulating sulfation of perineuronal chondroitins during vestibular compensatin [Seoul, Korea. Aug. 23-27, 2015], Proc. 9th InternationalConference on Proteoglycans & 10th Pan-Pacific Connective Tissue Societies Symposium. 2015. |
| Shum D.K.Y., Cai S., Han L. and Chan Y.S., Small molecule approach to direct differentiation of human induced pluripotent stem cells to sensory neurons 665.18/B44. [Chicago. Oct. 15-19, 2015], Soc. Neuroscience Abstract (USA). 2015. |
| Szeto Y.Y., Chu K.H., Au Y.K., Huang Y.H., Wynn S., Mak A., Chan Y.S., Lovell-Badge R., Chan W.Y., Jauch R., Fritzsch B., Sham M.H. and Cheah K.S.E., The SOX9Y440X campomelic dysplasia mutation disrupts endolymph homeostasis., Gordon Research Conference: Fibroblast Growth Factors in Development & Disease. 2016. |
| Tam K.W., Chan Y.S. and Shum D.K.Y., Chondroitin sulphate-derived disaccharides: a potential drug for axons regrowing across the glial scar, Neuroscience Symposium 2016 & Annual Scientific Conference of The Hong Kong Society of Neurosciences: Nature and Nurture in Brain Functions. 2016. |
| Tam K.W., Chan Y.S. and Shum D.K.Y., Use of chondroitin sulphate lyases in scar treatment: kinetic considerations of macromolecular crowding, 45th IUPAC World Chemistry Congress. 2015. |
| Tam K.W., Chan Y.S. and Shum D.K.Y., Use of chondroitin sulphate lyases in scar treatment: kinetic considerations of macromolecular crowding [Busan, Korea. Aug. 9-14, 2015], Proc. 45th IUPAC World Chemistry Congress. 2015. |
| Tam K.W., Chan Y.S. and Shum D.K.Y., Use of chondroitin sulphate-derived disaccharides as a potential drug to overcome the axonal growth barrier at the glial scar [HK. March 12-13, 2016], Abstracts of 11th Int’l Symp. on Healthy Aging: Science and Aging – An Era of Discovery. 2016, 63. |
| Tam K.W., Chan Y.S. and Shum D.K.Y., Use of chondroitin sulphate-derived disaccharides as a potential drug to overcome the axonal growth barrier at the glial scar, 11st International Symposium on Healthy Aging: Science and Aging: An Era of Discovery. 2016. |
| Tsui Y.P., Tam K.W., Shum D.K.Y. and Chan Y.S., Schwann cells demonstrated lineage plasticity in culture and acquired oligodendrocyte phenotypes [HK. March 12-13, 2016] , Abstracts of 11th Int’l Symp. on Healthy Aging: Science and Aging – An Era of Discovery. 2016, 50. |
| Tsui Y.P., Tam K.W., Shum D.K.Y. and Chan Y.S., Schwann cells demonstrated lineage plasticity in culture and acquired oligodendrocyte phenotypes, Gordon Research Conference - Cellular & Molecular Neuroscience. 2016. |
| Tsui Y.P., Tam K.W., Shum D.K.Y. and Chan Y.S., Schwann cells demonstrated lineage plasticity in culture and acquired oligodendrocyte phenotypes, Neuroscience Symposium 2016 & Annual Scientific Conference of The Hong Kong Society of Neurosciences: Nature and Nurture in Brain Functions. 2016. |
| Wu L.K., Shum D.K.Y. and Chan Y.S., Astrocytic regulation of perineuronal net formation [HK. May 18, 2016], Proc. Neuroscience Symposium 2016 & Scientific Conference of The Hong Kong Society of Neurosciences. 2016, 54. |
| Researcher : Chang RCC |
| Project Title: | Significance of molecular signaling for protein translation control in neurodegeneration of amyotrophic lateral sclerosis |
| Investigator(s): | Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | Liu Po Shan/Dr Vincent Liu Endowment Fund for Motor Neuron diseases - General Award |
| Start Date: | 03/2008 |
| Project Title: | Elucidating pathological mechanisms of visual impairment in the pathogenesis of Alzheimer’s disease: from basic science to innovative approach of disease monitoring (CRF) |
| Investigator(s): | Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding for Incubating Group-based Collaborative Research Projects |
| Start Date: | 01/2015 |
| Project Title: | Elucidating the molecular defects associated with PTEN mutations in Autism Spectrum Disorders |
| Investigator(s): | Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 04/2015 |
| Project Title: | Advancement for developing drug against Lewy Body Dementia by establishing a pre-clinical experimental model |
| Investigator(s): | Chang RCC, Ho YS, Ng TW, Chu MT |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Fund for Translational and Applied Research |
| Start Date: | 04/2015 |
| Completion Date: | 12/2016 |
| Project Title: | Investigating molecular mechanisms underlying escitalopram as neuroprotectant & antidepressant in AD mice |
| Investigator(s): | Chang RCC, Ho YS, Ng TW, Hung HLC |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2015 |
| Project Title: | Investigating oxyresveratrol as potential neuroprotective drug in experimental models of Parkinson’s disease |
| Investigator(s): | Chang RCC, Ng KM, Wang M, Ho YS |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 05/2015 |
| Project Title: | Investigation of drugs targeting mitochondrial dynamics and reactive oxygen species for Parkinson’s disease treatment using in vitro and in vivo imaging models |
| Investigator(s): | Chang RCC, Hung HLC |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 06/2015 |
| Project Title: | Society for Neuroscience 2015; Proteasome and autophagic degradation in an In vitro model of Alzheimer’s disease |
| Investigator(s): | Chang RCC |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 10/2015 |
| Completion Date: | 10/2015 |
| Project Title: | Investigating the significance of JNK3 and PKR in modulating the fate of neurons in cigarette smoking-induced neurodegeneration as risk factor of Alzheimer's disease |
| Investigator(s): | Chang RCC, Ho YS |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2016 |
| List of Research Outputs |
| Alexandria A., LIU K.L., Chang R.C.C., Pearce R.K.B. and Gentleman S.M., Differential expression of galanin in the cholinergic basal forebrain of patients with Lewy body disorders., Acta Neuropathologica Communications. 2015, 3: 1-12. |
| CHENG S.Y., Hung H.L.C. and Chang R.C.C., Differential roles of the ubiquitin-proteasome system and autophagy in experimental models of Alzheimer’s Disease, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| Chang R.C.C., Application of live-cell imaging to investigate the impact of beta-amyloid peptide on mitochondria, The 6th Federation of Asia-Oceanian Neuroscience Society (FAONS) Congress and 11th Biennia Conference of Chinese Society of Neuroscience, Wuzhen, CHINA. 2015. |
| Chang R.C.C., Editor-in-Chief, American Journal of Alzheimer's Disease and Other Dementias. 2016. |
| Chang R.C.C., Editor-in-Chief, American Journal of Alzheimer's Disease and Other Dementias. 2015. |
| Chang R.C.C., Editorial, American Journal of Alzheimer's Disease and Other Dementias. 2016, 31: 193. |
| Chang R.C.C., Elucidating the pathological mechanisms of depression as risk factor of developing Alzheimer's disease and potential prevention by Chinese medicine Lyceum barbarum , The 2nd Shenzhen-Hong Kong Alzheimer's Disease Conference, Shenzhen, CHINA. 2015. |
| Chang R.C.C., Guest Editor, "Behold the Eye in Parkinson's Disease and Alzheimer's Disease", Frontiers in Neurology. 2016. |
| Chang R.C.C., Guest Editor, "Relationships between Mitochondria and Neuroinflammation: Implications for Alzheimer's Disease", Current Topic in Medicinal Chemistry. 2015. |
| Chang R.C.C., Investigating mechanism of depression as risk factors for Alzheimer's disease, The Joint Congress of the 45th Annual Meeting of Japanese Society of Neuropsychopharmacology and the 37th Annual Meeting of Japanese Society of Biological Psychiatry, Tokyo, JAPAN. 2015. |
| Chang R.C.C., Investigating pathological mechanisms of depression as risk factors for Alzheimer's disease, The 9th Annual Scientific Meeting for Hong Kong Society of Biological Psychiatry, Hong Kong . 2015. |
| Chang R.C.C., Investigating protein degradation pathways in Alzheimer's disease, International Alzheimer's Disease Conference. 2016. |
| Chang R.C.C., Cheng S.Y. and Hung H.L.C., Investigating protein degradation pathways in Alzheimer’s disease, International Alzheimer's Disease Conference. 2016, 24. |
| Chang R.C.C., Significance of depression as a risk factor for Alzheimer's disease and prevention of progressive neurodegeneration by anti-acing Chinese medicine Lyceum barbarum, The 9th Pong Ding Yuen International Symposium on Traditional Chinese Medicine for Mental Health: From Bedside to Bench. 2015. |
| Chang R.C.C., Travel Award, Japanese Society of NeuropsychoPharmacology. 2015. |
| Chang R.C.C., Wolf berry as anti-acing to prevent and delay neurodegeneration in Alzheimer's disease, The 6th International Conference of Food Factor, Seoul, KOREN. 2015. |
| Cheng S.Y., Hung H.L.C. and Chang R.C.C., Differential roles of the ubiquitin-proteasome system and autophagy in experimental models of Alzheimer’s disease. , Annual Scientific Conference of The Hong Kong Society of Neuroscience 2016. 23. |
| Chiu P.W., Hui S.K., Chan Q., Azman R.R., Chang R.C.C., Chan R.C.K., Chu L.W. and Mak H.K.F., Age-related alterations in glutamatergic neurotransmission in the anterior and posterior cingulate cortices, The 24th Annual Meeting of ISMRM, Singapore. 2016, 3219. |
| Chiu P.W., Hui S.K., Chan Q., Aman R.R.A.R., Chang R.C.C., Chan R.C.K., Chu L.W. and Mak H.K.F., Alterations In Glutamatergic Neurotransmission In The Anterior And Posterior Cingulate Cortices Of The Normal Aging Brain, International Alzheimer’s Disease Conference 2016. Hong Kong. |
| HUANG C., Ho Y.S., Ng T.W., Irwin M.G., Chang R.C.C. and Wong G.T.C., Effect of continuous propofol infusion to rat on tau phosphorylation with or without temperature control., Journal of Alzheimer's Disease. 2016, 51: 213-226. |
| HUANG C., Ng T.W., Chu M.T., Chang R.C.C. and Wong G.T.C., The relationship between tau protein phosphorylation and surgical trauma in post operative cognitive dysfunction., The 11th International Conference on Healthy Aging. 2016, 62. |
| HUANG C., Ng T.W., Chu M.T., Chang R.C.C. and Wong G.T.C., The relationship of tau protein and inflammation within cognitive dysfunction induced by laparotomy, International Alzheimer’s Disease Conference 2016. 63. |
| HUANG C., Ng T.W., Chu M.T., Chang R.C.C. and Wong G.T.C., The role of tau protein and inflammation within cognitive dysfunction induced by laparotomy in young animal. , Annual Scientific Conference of The Hong Kong Society of Neuroscience 2016. 36. |
| Ho Y.S., Tung C.Y. and Chang R.C.C., A pilot study on the awareness and help seeking preferences of middle-aged Chinese carers towards dementia in Hong Kong. , The 11th International Conference on Healthy Aging. 2016, 67. |
| Hung H.L.C., Cheng S.Y., Lee S.M.Y. and Chang R.C.C., The dynamic mitochondria network in neurodegeneration., Annual Scientific Conference of The Hong Kong Society of Neuroscience 2016. 25. |
| Hung H.L.C., Cheng S.Y., Lee S.M.Y. and Chang R.C.C., The dynamic mitochondrial network in Alzheimer’s disease, International Alzheimer’s Disease Conference 2016. 62. |
| LEUNG W.Y.Y., Ng T.W., Cheng S.Y., Hung H.L.C., Chu M.T., Chang R.C.C. and Wong G.T.C., The effect of sevoflurane in cognition. , The 11th International Conference on Healthy Aging. 2016, 71. |
| LEUNG W.Y.Y., Ng T.W., Cheng S.Y., Hung H.L.C., Chu M.T., Chang R.C.C. and Wong G.T.C., The effect of sevoflurane in cognitive and synaptic function, International Alzheimer’s Disease Conference . 2016, 64. |
| LIU K.L., Hurry M.E.D., DeFelice J., Lai H.M., Pearce R.K.B., Wong G.T.C., Chang R.C.C. and Gentleman S.M., Bringing CLARITY to human brain: visualisation of Lewy pathology in three-dimensions. , Neuropathology and Applied Neurobiology. 2015, 1-15. |
| Lai H.M., LIU K.L., Ng W.L., DeFelice J., Lee W.S., LI H., LI W., NG H.M., Chang R.C.C., Lin B., Wu W. and Gentleman S.M., Rationalisation and validation of an acrylamide-free procedure in three-dimensional histological imaging, PloS One. 2016, 11: e0158628. |
| Man I.S.C., Hung H.L.C., Lee S.M.Y. and Chang R.C.C., Investigation of drugs targeting mitochondrial dynamics and reactive oxygen species for Parkinson’s disease treatment. , The 11th International Conference on Healthy Aging. 2016, 62. |
| Manthey A.L., Chang R.C.C., So K.F. and Chiu K., Understanding Alzheimer’s disease in Hong Kong: can regular retinal health checkups be used to diagnose, monitor and study disease pathogenesis?, Hong Kong Journal of Ophthalmology. 2016, 20: 1-9. |
| NG H.L.L., HUANG Y., Chang R.C.C. and Lai S.W.C., Altered Dendritic Spine Plasticity in a Mouse Depression Model, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| NG H.L.L., Chang R.C.C. and Lai S.W.C., Altered dendritic spine plasticity in a mouse depression model, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| NG H.L.L., Chang R.C.C. and Lai S.W.C., Dendritic spine plasticity in depression animal model, CNRS - Conférences Jacques Monod: Optical imaging of brain connectivity: from synapses to networks in action. 2016. |
| NG H.L.L., HUANG Y., Chang R.C.C. and Lai S.W.C., Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences, Altered dendritic spine plasticity in a mouse depression model. 2016. |
| Poon C.H., Ho Y.S., YOU R., Tse J., Chiu K. and Chang R.C.C., PKR deficiency alters E. coli-induced sickness behaviors but does not exacerbate neuroimmune responses or bacterial load., Journal of Neuroinflammation. 2015, 12: 1-19. |
| Poon D.C.H., Ho Y.S., Lau C.F. and Chang R.C.C., Oral feeding of minocycline attenuates glial activation and reductions of tau and drebrin in response to systematically injected cytokines. , Hong Kong Medical Journal. 2016, 22 Suppl.3: 16-21. |
| Poon D.C.H., Ho Y.S., Chiu K., Wong H.L. and Chang R.C.C., Sickness: From the focus on cytokines, prostaglandins, and complement factors to the perspectives of neurons, Neuroscience and Biobehavioral Reviews. Elsevier, 2015, 30-45. |
| SHAH A.N., Hung H.L.C., CHENG S.Y. and Chang R.C.C., The effect of Oxyresveratrol on endoplasmic reticulum stress in Parkinson’s disease, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| SHAH A.N., Hung H.L.C., Cheng S.Y. and Chang R.C.C., The effect of oxyresveratrol on endoplasmic reticulum stress in Parkinson’s disease., Annual Scientific Conference of The Hong Kong Society of Neuroscience 2016. 50. |
| SHAH A.N., Hung H.L.C., Cheng S.Y. and Chang R.C.C., The role of oxyresveratrol in mitigating cellular toxicity in Parkinson’s disease, The 11th International Conference on Healthy Aging. 2016, 63. |
| Sy L.K., Lok C.N., Wang J., Liu Y., Cheng L., WAN P.K., Leung C.T.G., Cao B., Kwong W.L., Chang R.C.C. and Che C.M., Identification of “sarsasapogenin-aglyconed” timosaponins as novel Aβ-lowering modulators of amyloid precursor protein processing, Chem. Sci.. United Kingdom, Royal Society of Chemistry, 2016, 7: 3206-3214. |
| WAN P.K., Lok C.N., Wang J., Liu Y., Cheng L., Leung C.T.G., CAO B., Kwong W.L., Che C.M. and Chang R.C.C., Identification of timosaponins as novel A lowering modulators of amyloid precursor protein processing, International Alzheimer’s Disease Conference 2016. 61. |
| Wong G.T.C., HUANG C., Ng T.W., Chu M.T. and Chang R.C.C., Differential inflammatory effects in the brain and post operative cognitive performance from surgical trauma when compared with anaesthesia exposure without surgery, Euroanaesthesia 2016. |
| Xing R., Zhang Y., Xu H., Luo X., Chang R.C.C., Liu J. and Yang X., Spatial memory impairment by TRPC1 depletion is ameliorated by environmental enrichment., Oncotarget. 2016, 7: 27855-27873. |
| YOU R., Cheng S.Y., Hung H.L.C., Ho Y.S., Lai S.W.C. and Chang R.C.C., Investigating the effects of silica nanoparticles on affective and cognitive behaviors and on synapse in vivo and in vitro. , International Alzheimer’s Disease Conference 2016. 64. |
| YOU R., Cheng S.Y., Hung H.L.C., Ho Y.S. and Chang R.C.C., Investigating the impact of Silica Nanoparticles on affective and cognitive behaviors, and on synapse in vivo and in vitro. , The 11th International Conference on Healthy Aging. 2016, 61. |
| Yang X., Zhang Y., Xu H., Luo X., Yu J., Liu J. and Chang R.C.C., Neuroprotection of Coenzyme Q10 in Neurodegenerative Diseases, Current Topics in Medicinal Chemistry. 2016, 16: 858-866. |
| Ying M., Sui X., Zhang Y., Sun Q., Qu Z., Luo X., Chang R.C.C., Ni J., Liu J. and Yang X.F., Identification of Novel Key Molecules Involved in Spatial Memory Impairment in Triple Transgenic Mice of Alzheimer's Disease, Molecular Neurobiology. 2016, 1-16. |
| Researcher : Cheah KSE |
| Project Title: | Defining the role of the transcription factor Sox9 in skeletal development by tissue-specific gene inactivation |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | UK/Hong Kong Joint Research Scheme |
| Start Date: | 02/1998 |
| Project Title: | 4th Pan-Pacific Connective Tissues Societies Symposium Abnormal Regulation of Cartilage and Bone Growth in Transgenic Mice Expressing a Collagen X SMCD Mution |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/1999 |
| Project Title: | Human Genome Meeting 2001 Genomic Analysis of the Mutant Locus in the Novel Transgenic Mouse Mutant, Yellow Submarine (ysb) |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2001 |
| Project Title: | 67th Cold Spring Harbor Symposium on Quantitative Biology - The Cardiovascular System An Essential Role for Type IIA Procollagen in Heart Development |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2002 |
| Project Title: | 1st Annual Meeting of the American Society for Matrix Biology Type IIA Procollagen is Essential for Proper Heart Development |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2002 |
| Project Title: | The Gordon Research Conference on Cartilage Biology and Pathology Chondrocytes Survive ER Stress Caused by Unfolded Proteins and Differentiation is Re-programmed |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2005 |
| Project Title: | 11th Human Genome Meeting Procollagen IIA Facilitates BMP Signaling in Heart Development |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2006 |
| Project Title: | Cold Spring Harbor Laboratory Meeting on Mouse Molecular Genetics Insight into the Molecular Pathogenesis of Campomelic Dysplasia Received By A Conditional SOX9 Mutant Mouse Model |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2006 |
| Project Title: | Role of Sox2 in the stemness of dermal precursors |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 03/2010 |
| Project Title: | Functional analyses of how genomic variation affects personal risk for degenerative skeletal disorders |
| Investigator(s): | Cheah KSE, Chan BP, Chan D, Cheung KMC, Jin D, Lian Q, Luk KDK, Sham PC, Zhang MQ, Cherny SS, Huang J, Ng RK, Samartzis D, Song Y, Wang JJ |
| Department: | Biochemistry |
| Source(s) of Funding: | Theme-based Research Scheme |
| Start Date: | 01/2013 |
| Project Title: | Genetic analyses of the roles of Sox2 and Sox18 in hair follicle development |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2013 |
| Project Title: | Stem cells: Niches, Regeneration & Repair |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | Croucher Advanced Study Institute |
| Start Date: | 03/2013 |
| Project Title: | Development and Reproduction |
| Investigator(s): | Cheah KSE, Ng EHY, Wu EX |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding for Strategic Research Theme |
| Start Date: | 06/2013 |
| Project Title: | Identifying critical transitions and gene regulatory networks controlling phases of chondrocyte differentiation in the growth plate |
| Investigator(s): | Cheah KSE, Wang JJ, Chan D, Ng RK |
| Department: | Biochemistry |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2014 |
| Project Title: | Mechanistic insights into the genesis and physiological role of hypertrophic chondrocyte-derived osteoblasts |
| Investigator(s): | Cheah KSE, Chan D |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Project Title: | Craniofacial Morphogenesis & Tissue Regeneration; Transcriptional control of sensory progenitor specification in the inner ear |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 03/2014 |
| Project Title: | Mechanisms controlling determination of sensory versus non-sensory fate in inner ear development |
| Investigator(s): | Cheah KSE, Wong YME, Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2014 |
| Project Title: | Global Spine Congress 2015; The changing RNAome of the developing nucleus pulposus of the intervertebral disc - implications for Intervertebral Disc Disease |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2015 |
| Project Title: | Gordon Research Conference on Bones and Teeth; Dissecting the transition from hypertrophic chondrocyte to osteoblast in skeletal development and growth |
| Investigator(s): | Cheah KSE |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 02/2016 |
| List of Research Outputs |
| CHU T.L., Tsang K.Y., Zhou Z. and Cheah K.S.E., The role of MMP14 in lineage progression of hypertrophic chondrocytes, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Cheah K.S.E., Au Y.K., Wynn S., Tan T., YIP K.H.R. and Chan D., Genetic control of hypertrophic chondrocyte to osteoblast differentiation in development and skeletal disorders, American Association of Anatomists (AAA) 2016 Annual Meeting. 2016. |
| Cheah K.S.E., Au Y.K., Wynn S., Tan T., YIP K.H.R. and Chan D., Genetic control of hypertrophic chondrocyte to osteoblast differentiation in development and skeletal disorders, American Association of Anatomists (AAA) 2016 Annual Meeting, San Diego, USA, April 2-6, 2016.. 2016. |
| Cheah K.S.E., Mechanisms of adaptation and survival in ER stress induced chondrodysplasia, A Special Seminar at the Department of Genetics, MD Anderson Cancer Center, The University of Texas, USA, February 19, 2016. 2016. |
| Cheah K.S.E., Neofunctionalization of SOXE proteins in the evolution of the neural crest, Symposium on Stem Cells, Gene Regulatory Networks and the Evolution of Vertebrates (A Symposium Recognizing the Contributions of Marianne Bronner) , Pasadena, CA, USA, January 29-30, 2016. |
| Cheah K.S.E., Neofunctionalization of SOXE proteins in the evolution of the neural crest, Symposium on Stem Cells, Gene Regulatory Networks and the Evolution of Vertebrates, Pasadena, CA, USA, January 29-30, 2016. |
| Cheah K.S.E., Au Y.K., Niu B., Chan D. and Zhang M.Q., SPINE-GEL: a global gene expression library for the developing nucleus pulposus., Spine Week, Singapore, May 16-20, 2016. |
| Cheah K.S.E., Single cell analysis and the potential use of photonics, Max Planck Society – Croucher Foundation Joint Workshop, Hong Kong, April 5-7, 2016.. 2016. |
| GUO S., Tsang K.Y., Au Y.K., Tam W.K., Leung V.Y.L. and Cheah K.S.E., Generation of a Chordoma Cell Line: a Model of Human Notochordal Cells?, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Kudelko M.A., Sharma R., Cheah K.S.E. and Chan D., Comparison of proteomic datasets from hypertrophic chondrocytes in response to ER stress, Data Brief. 2016, 7: 449-51. |
| LI H.Y., CHOOI W.H., Chan D., Cheah K.S.E. and Chan B.P., Development of protein-based 3D culture system for bovine nucleus pulposus cells., TERMIS 4th World Congress. Boston, USA. 5-9 Sep 2015. |
| LI Y., Samartzis D., Campbell D.D., Cherny S.S., Cheung K.M.C., Luk K.D.K., Karppinen J., Song Y., Cheah K.S.E., Chan D. and Sham P.C., Two subtypes of intervertebral disc degeneration distinguished by large-scale population-based study, The Spine Journal. 2016, pii: S1529-9430(16)30095-X. |
| LIM F.L., ZHANG C., Tam W.K., Au Y.K., Chan D., Tuan R.S., Cheah K.S.E., Cheung K.M.C. and Leung V.Y.L., Nucleus Pulposus Cell Vacuolation: A New Perspective From N-Cadherin/Cadherin 2 Function, ORS 3rd International Spine Research Symposium, Philadelphia, USA . 2015. |
| Liu A.J., RAO Y., Cheung M.P.L., Hui M.N., Wu M.H., Niu B., Chan L.K., Cheah K.S.E. and Cheung M.C.H., Coordinated action of Nedd9 and Dlc1 in neural crest motility, Proceedings of Avian Model Systems 9: A New Integrative Platform. 2016. |
| Liu A.J., Ho S.H., Hui M.N., Cheung M.P.L., Wu M.H., Ho C.K.I., Niu B., Cheah K.S.E. and Cheung M.C.H., Sox9-dependent pathway in regulating neural crest cell motility, Neural Crest & Cranial Placodes Gordon Research Conference Development, Malformations and Cancers. 2015. |
| Szeto Y.Y., Chu K.H., Au Y.K., Huang Y.H., Wynn S., Mak A., Chan Y.S., Lovell-Badge R., Chan W.Y., Jauch R., Fritzsch B., Sham M.H. and Cheah K.S.E., The SOX9Y440X campomelic dysplasia mutation disrupts endolymph homeostasis., Gordon Research Conference: Fibroblast Growth Factors in Development & Disease. 2016. |
| Tam V., Solis N., Overall C., Klein T., Cheung K.M.C., Cheah K.S.E. and Chan D., Degradome of the Intervertebral Disc, Global Spine Congress / World Forum for Spine Research. 2016. |
| Tsang K.Y., Wu M.H., Zhang M., Gu J., Yu X., Chan D. and Cheah K.S.E., Dissecting the transition from hypertrophic chondrocyte to osteoblast in skeletal development and growth, Gordon Research Conference – Bones & Teeth, Galveston, TX, USA, February 14-19, 2016. |
| Tsang K.Y., Chan W.C.W., Cheng Y.W., Chik H., Boot-Handford R.P., Boyde, A.J.S., Cheung K.M.C. and Cheah K.S.E., Chan D., Pathological ER stress impairs osteocyte maturation causing hyperostosis in mice., Gordon Research Conference- Stress Proteins in Growth, Development & Disease, Italy, July 5-10, 2015. |
| Tsang K.Y., Chan W.C.W., Cheng Y.W., Chik H., Boot-Handford R.P., Boyde A., Jones S.H.E.I.L.A., Cheung K.M.C., Cheah K.S.E. and Chan D., Pathological ER stress impairs osteocyte maturation causing hyperostosis in mice, Gordon Research Conference on Stress Proteins in Growth, Development & Disease. 2015. |
| Tsang K.Y., Li X., Gu J., Chan D., Zhang M.Q. and Cheah K.S.E., Reconstructing the chondro-osteoblastic lineage by single cell RNA-seq, Single Cell Biology, 8-10 March 2016, Wellcome Genome Campus, Hinxton, Cambridge, UK. 2016. |
| Tsang K.Y., Chan D. and Cheah K.S.E., Wiley Blackwell Prize 2016, In: Harukazu Nakamura, Development, Growth & Differentiation, John Wiley & Sons, Inc.. 2016. |
| Wang C., Tan Z., Tsang K.Y., Ron D., Itoh N., Chan D. and Cheah K.S.E., The PERK pathway attenuates ER stress in hypertrophic chondrocyte via Sox9 and FGF21., Gordon Research Conference- Stress Proteins in Growth, Development & Disease, Italy, July 5-10, 2015. |
| XIONG C., LI Y., RAI F.M., SANDELL L., ZHANG Y., Song Y., Cheah K.S.E., Sham P.C. and Chan D., Genetic contribution to degeneration and repair potentials of the intervertebral disc in mice, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| XIONG C., LI Y., Rai F.M., Sham P.C., ZHANG Y., Song Y., Cheah K.S.E. and Chan D., Genetic contribution to intervertebral discs integrity maintenance in mouse model, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| YIP K.H.R., Au Y.K., Chan D. and Cheah K.S.E., Investigating molecular pathogenesis of Campomelic Dysplasia, 2016 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| YIP K.H.R., Au Y.K., Chan D. and Cheah K.S.E., Investigating molecular pathogenesis of Campomelic Dysplasia, 2016 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, The Chinese University of Hong Kong, June 11, 2016. |
| YIP K.H.R., Au Y.K., Chan D. and Cheah K.S.E., Investigating molecular pathogenesis of Campomelic Dysplasia, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Yee A., Lam P.Y., Tam V., Chan W.C.W., Chu I.K., Cheah K.S.E., Cheung K.M.C. and Chan D., Fibrotic-like changes in degenerate human intervertebral discs revealed by quantitative proteomic analysis, Osteoarthritis and Cartilage. 2016, 24: 503-513. |
| ZHANG C., LIM F.L., Tam W.K., Au Y.K., Cheah K.S.E., Cheung K.M.C. and Leung V.Y.L., Cadherin2/N-cadherin Deficiency In Nucleus Pulposus Causes Loss Of Cell Vacuolation And Disc Integrity, 62nd Annual Meeting of Orthopaedic Research Society, Orlando, USA. 2016. |
| Researcher : Chen J |
| Project Title: | CFTR Activation by Regional Phosphorylation on the R Domain |
| Investigator(s): | Chen J |
| Department: | Physiology |
| Source(s) of Funding: | Early Career Scheme (ECS) |
| Start Date: | 09/2013 |
| Project Title: | Investigating the molecular mechanisms how ΔF508 mutation delays phosphorylation-dependent CFTR activation |
| Investigator(s): | Chen J |
| Department: | Physiology |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2014 |
| Project Title: | Molecular mechanisms of bicarbonate transport and impaired pH sensitivity in ΔF508-CFTR |
| Investigator(s): | Chen J |
| Department: | Physiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 03/2015 |
| Project Title: | Molecular mechanisms of bicarbonate transport and impaired pH sensitivity in ΔF508-CFTR |
| Investigator(s): | Chen J, Chan YS |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2015 |
| Project Title: | The 29th Annual North American Cystic Fibrosis Conference; CONTACT-DEPENDENT VIRULENCE OF P. AERUGINOSA IS REQUIRED FOR ELEVATING PARACELLULAR CONDUCTANCE OF CULTURED PIG TRACHEAL EPITHELIA |
| Investigator(s): | Chen J |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 10/2015 |
| Completion Date: | 10/2015 |
| Project Title: | Investigating the mechanisms how Pseudomonas aeruginosa affects the function of airway epithelia |
| Investigator(s): | Chen J, Li NF, Wong PF |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2016 |
| Project Title: | Regional function around the F508 residue in protein processing and channel gating of CFTR |
| Investigator(s): | Chen J |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 03/2016 |
| List of Research Outputs |
| AN L., JIANG Y., Ng H.W.H., CHEN J., GONG Q. and Huen M.S.Y., USP7 Enforces RNF169-dependent DNA Double-Strand Break Responses, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| CHEN X. and Chen J., Deletions around the F508 residue revealed the importance of regional integrity in protein processing of the cystic fibrosis transmembrane conductance regulator, 29th North American Cystic Fibrosis Conference. 2015. |
| CHEN X. and Chen J., Mutations On The Residues N505 and Y512 Disrupted Protein Processing Of The Cystic Fibrosis Transmembrane Conductance Regulator By Different Mechanisms, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| CHEN X., ZHU S., XU W. and Chen J., Regional Disturbances Around the F508 Residues Exhibited Various Impacts on The function of The Cystic Fibrosis Transmembrane Conductance Regulator, ATP-binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases. 2016. |
| CHEN X., ZHU S., XU W. and Chen J., Regional Disturbances Around the F508 Residues Exhibited Various Impacts on The function of The Cystic Fibrosis Transmembrane Conductance Regulator, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| XU W., Li N.F. and Chen J., Apical Na+ is required for decreasing transepithelial Na+ current of cultured pig tracheal epithelia by the apical Krebs solution, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| XU W., Li N.F. and Chen J., Contact-dependent virulence of P. aeruginosa is required for elevating paracellular conductance of cultured pig tracheal epithelia, 29th Annual North American Cystic Fibrosis Conference. 2015. |
| XU W., Li N.F. and Chen J., Effects of the apical Krebs solution on ion transport of cultured pig tracheal epithelia, American Thoracic Society (ATS) 2016 International Conference. 2016. |
| XU W., Li N.F. and Chen J., Effects of the apical Krebs solution on ion transport of cultured pig tracheal epithelia, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| ZHU S. and Chen J., Bacterial killing of cultured pig tracheal epithelia was not altered by HCO3−-free medium, American Thoracic Society (ATS) 2016 International Conference. 2016. |
| ZHU S., XU W., Li N.F. and Chen J., Roles of bicarbonate ion in ion transport and bacterial killing of cultured pig tracheal epithelia, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Researcher : Cheng SY |
| List of Research Outputs |
| CHENG S.Y., Hung H.L.C. and Chang R.C.C., Differential roles of the ubiquitin-proteasome system and autophagy in experimental models of Alzheimer’s Disease, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| Chang R.C.C., Cheng S.Y. and Hung H.L.C., Investigating protein degradation pathways in Alzheimer’s disease, International Alzheimer's Disease Conference. 2016, 24. |
| Cheng S.Y., Hung H.L.C. and Chang R.C.C., Differential roles of the ubiquitin-proteasome system and autophagy in experimental models of Alzheimer’s disease. , Annual Scientific Conference of The Hong Kong Society of Neuroscience 2016. 23. |
| Hung H.L.C., Cheng S.Y., Lee S.M.Y. and Chang R.C.C., The dynamic mitochondria network in neurodegeneration., Annual Scientific Conference of The Hong Kong Society of Neuroscience 2016. 25. |
| Hung H.L.C., Cheng S.Y., Lee S.M.Y. and Chang R.C.C., The dynamic mitochondrial network in Alzheimer’s disease, International Alzheimer’s Disease Conference 2016. 62. |
| LEUNG W.Y.Y., Ng T.W., Cheng S.Y., Hung H.L.C., Chu M.T., Chang R.C.C. and Wong G.T.C., The effect of sevoflurane in cognition. , The 11th International Conference on Healthy Aging. 2016, 71. |
| LEUNG W.Y.Y., Ng T.W., Cheng S.Y., Hung H.L.C., Chu M.T., Chang R.C.C. and Wong G.T.C., The effect of sevoflurane in cognitive and synaptic function, International Alzheimer’s Disease Conference . 2016, 64. |
| SHAH A.N., Hung H.L.C., CHENG S.Y. and Chang R.C.C., The effect of Oxyresveratrol on endoplasmic reticulum stress in Parkinson’s disease, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| SHAH A.N., Hung H.L.C., Cheng S.Y. and Chang R.C.C., The effect of oxyresveratrol on endoplasmic reticulum stress in Parkinson’s disease., Annual Scientific Conference of The Hong Kong Society of Neuroscience 2016. 50. |
| SHAH A.N., Hung H.L.C., Cheng S.Y. and Chang R.C.C., The role of oxyresveratrol in mitigating cellular toxicity in Parkinson’s disease, The 11th International Conference on Healthy Aging. 2016, 63. |
| YOU R., Cheng S.Y., Hung H.L.C., Ho Y.S., Lai S.W.C. and Chang R.C.C., Investigating the effects of silica nanoparticles on affective and cognitive behaviors and on synapse in vivo and in vitro. , International Alzheimer’s Disease Conference 2016. 64. |
| YOU R., Cheng S.Y., Hung H.L.C., Ho Y.S. and Chang R.C.C., Investigating the impact of Silica Nanoparticles on affective and cognitive behaviors, and on synapse in vivo and in vitro. , The 11th International Conference on Healthy Aging. 2016, 61. |
| Researcher : Cheung A |
| Project Title: | Roles and mechanisms of E2F1 and IGF2 in regulating chemosensitivity of esophageal cancer |
| Investigator(s): | Cheung A, Li B |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 12/2014 |
| Completion Date: | 05/2016 |
| Project Title: | Identification of miR-29c/FBXO31 as a key regulatory mechanism in esophageal cancer chemoresistance-functional validation and implication for therapy |
| Investigator(s): | Cheung A, Li B |
| Department: | Anatomy |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2015 |
| Project Title: | Role of miR-338-5p as a novel modulator of chemoresistance in esophageal cancer |
| Investigator(s): | Cheung A, Chan KW, Law SYK, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | miR-338-5p suppresses esophageal cancer invasion and metastasis through direct targeting of Id1 and PAK4 |
| Investigator(s): | Cheung A, Chan KW, Tsao GSW |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2016 |
| List of Research Outputs |
| Li B., XU W., Guan X., Qin Y...R..., Law S.Y.K., Lee N.P.Y., Chan K.T., Tam P.Y., Li Y.Y., Chan K.W., Yuen H...F..., Tsao G.S.W., He Q...Y... and Cheung A., Competitive Binding Between Id1 and E2F1 to Cdc20 Regulates E2F1 Degradation and Thymidylate Synthase Expression to Promote Esophageal Cancer Chemoresistance, Clinical Cancer Research. 2016, 22: 1243-1255. |
| Li B., Xu W., Liu J. and Cheung A., Identification of miR-29c/FBXO31 as a key regulatory mechanism in esophageal cancer chemoresistance, International Conference on Antimicrobial Agents and Chemotherapy, Valencia, Spain, August 04-06, 2015. |
| Li J., Li B., XU W., Chan K.W., Guan X., Qin Y.R., Lee N.P.Y., Chan K.T., Law S.Y.K., Tsao G.S.W. and Cheung A., Role of AMPK signaling in mediating the anticancer effects of silibinin in esophageal squamous cell carcinoma, Expert Opinion on Therapeutic Targets. 2016, 20: 7-18. |
| Su H., Tiwari A.F.Y., Ngan H.Y.S., Yip Y.L., Cheung A., Tsao G.S.W. and Deng W., Extremely stringent activation of p16INK4a prevents immortalization of uterine cervical epithelial cells without human papillomavirus oncogene expression, Oncotarget. 2016. |
| Xu W., Li B. and Cheung A., Role of miR-29c in modulating the paracrine crosstalk between esophageal cancer cells and stromal fibroblasts in the tumor microenvironment, International Conference on Antimicrobial Agents and Chemotherapy, Valencia, Spain, August 04-06, 2015. |
| ZHU D., ZHANG J., Deng W., Yip Y.L., Lung H.L., Tsang C.M., Law W.T., Yang J., Lau M.Y., Lung M.L., Cheung A. and Tsao G.S.W., Significance of NF-kB activation in immortalization of nasopharyngeal epithelial cells., Int. J. Cancer. 2015. |
| Researcher : Cheung KH |
| Project Title: | Nuclear Membrane Electrophysiology of Ryanodine Receptor And Its Regulation by cADPR |
| Investigator(s): | Cheung KH, Chen J |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2013 |
| Project Title: | Role of intracellular calcium release channels in Asthma pathogenesis |
| Investigator(s): | Cheung KH, Leung GPH |
| Department: | Physiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | Electrophysiological Characterization of the Two-Pore Channel 2 |
| Investigator(s): | Cheung KH |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2014 |
| Project Title: | Role of TMEM16A in the formation of epididymal microenvironment |
| Investigator(s): | Cheung KH |
| Department: | Physiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2015 |
| Project Title: | Role of presenilin-1 in pancreatic beta-cell insulin secretion |
| Investigator(s): | Cheung KH |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2016 |
| List of Research Outputs |
| HUNG C.H. and Cheung K.H., Role of Intracellular Calcium Release Channels in Asthma Pathogenesis, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Hao Y., Chow A.W., Yip W.C., Li C.H., Wan T.F., TONG C.K.B., Cheung K.H., Chan W.Y., Chen Y., Cheng C.H. and Ko W.H., G protein-coupled estrogen receptor inhibits the P2Y receptor-mediated Ca2+ signaling pathway in human airway epithelia, Pflügers Archiv - European Journal of Physiology. 2016. |
| LEE S.K., TONG C.K.B., CHENG W.H., HUNG C.H. and Cheung K.H., Characterization of Two-Pore Channel 2 by Nuclear Membrane Electrophysiology, Scientific Reports. 2016, 6: 20282. |
| LEE S.K., TONG C.K.B. and Cheung K.H., Regulation of Ryanodine Receptor Type 2 Single Channel Activities by Cyclic-ADP-ribose and Calcium, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Mak D.D., Cheung K.H., Toglia P., Foskett J.K., Ullah G. and Blackwell K.T., Analyzing and Quantifying the Gain-of-Function Enhancement of IP3 Receptor Gating by Familial Alzheimer’s Disease-Causing Mutants in Presenilins, PLOS Computational Biology. 2015, 11: e1004529. |
| TONG C.K.B. and Cheung K.H., Attenuation of Capacitative Calcium Entry in Familial Alzheimer’s disease by Gamma‐secretase Cleavage of Stromal Interaction Molecule 1, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| TONG C.K.B., Lai K.O. and Cheung K.H., Gamma-secretase cleaves stromal interaction molecule 1 induces capacitative calcium entry deficits in familial Alzheimer’s disease, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| TONG C.K.B., Lai K.O. and Cheung K.H., Gamma-secretase cleaves stromal interaction molecule 1 induces capacitative calcium entry deficits in familial Alzheimer’s disease, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| Toglia P., Cheung K.H., Mak D.D.O. and Ullah G., Impaired mitochondrial function due to familial Alzheimer's disease-causing presenilins mutants via Ca2+ disruptions, Cell Calcium. 2016. |
| Researcher : Cheung MCH |
| Project Title: | Investigating the roles of SOX9 in human neural stem cells |
| Investigator(s): | Cheung MCH |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | In vivo functional characterization of a Rho GTPase-activating protein, DLC1, in neural crest development |
| Investigator(s): | Cheung MCH |
| Department: | Anatomy |
| Source(s) of Funding: | Early Career Scheme (ECS) |
| Start Date: | 10/2014 |
| Project Title: | Single-cell transcriptomics in Sertoli cells and neural crest cells |
| Investigator(s): | Cheung MCH |
| Department: | Anatomy |
| Source(s) of Funding: | SFC / RGC Joint Research Scheme |
| Start Date: | 01/2015 |
| Completion Date: | 12/2015 |
| Project Title: | Elucidating the contribution of cross-regulatory interactions between SOX9 and SOX10 to melanoma progression |
| Investigator(s): | Cheung MCH, Lung HL |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2015 |
| Completion Date: | 08/2016 |
| Project Title: | Elucidating the role of Sox9 in cell fate acquisition of neural crest progenitors in the dorsal root ganglia |
| Investigator(s): | Cheung MCH, Sham MH, Lui VCH, Cheah KSE |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2015 |
| Project Title: | Avian Model Systems 9: A New Integrative Platform; Coordinated action of Dlc1 and Nedd9 in neural crest motility |
| Investigator(s): | Cheung MCH |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 03/2016 |
| Completion Date: | 03/2016 |
| Project Title: | Elucidating the role of Dlc1beta in motor neuron development |
| Investigator(s): | Cheung MCH |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2016 |
| List of Research Outputs |
| Cheung M.C.H., Molecular Regulation of Neural Crest Development and Melanoma Metastasis, HK/RGC-Scotland collaborative Reseach fellowship. 2015. |
| Cheung M.C.H., Transcriptional Network of Sox9 in Nerual Crest Motility, Symposium on Genetics, Developmental Genomics and Stem Cells. 2016. |
| Cheung M.C.H., Transcriptional regulatory network of SoxE proteins in neural crest motility, Advanced Study Workshop The Regulome: Genome Architecture and Single Cell Transcriptomics . 2016. |
| Liu A.J., RAO Y., Cheung M.P.L., Hui M.N., Wu M.H., Niu B., Chan L.K., Cheah K.S.E. and Cheung M.C.H., Coordinated action of Nedd9 and Dlc1 in neural crest motility, Proceedings of Avian Model Systems 9: A New Integrative Platform. 2016. |
| Liu A.J., Ho S.H., Hui M.N., Cheung M.P.L., Wu M.H., Ho C.K.I., Niu B., Cheah K.S.E. and Cheung M.C.H., Sox9-dependent pathway in regulating neural crest cell motility, Neural Crest & Cranial Placodes Gordon Research Conference Development, Malformations and Cancers. 2015. |
| RAO Y., Liu A.J., Cheung M.P.L., Chan L.K., Ng I.O.L. and Cheung M.C.H., Dlc1, a Rho GTPase-activating protein, is essential for cranial neural crest development, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| RAO Y., Liu A.J., Cheung M.P.L., Chan L.K., Ng I.O.L. and Cheung M.C.H., Dlc1, a Rho GTPase-activating protein, is essential for cranial neural crest development, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| YANG X. and Cheung M.C.H., Elucidating the role of DLC1 in Metastatic Melanoma, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Researcher : Cheung MPL |
| List of Research Outputs |
| Liu A.J., RAO Y., Cheung M.P.L., Hui M.N., Wu M.H., Niu B., Chan L.K., Cheah K.S.E. and Cheung M.C.H., Coordinated action of Nedd9 and Dlc1 in neural crest motility, Proceedings of Avian Model Systems 9: A New Integrative Platform. 2016. |
| Liu A.J., Ho S.H., Hui M.N., Cheung M.P.L., Wu M.H., Ho C.K.I., Niu B., Cheah K.S.E. and Cheung M.C.H., Sox9-dependent pathway in regulating neural crest cell motility, Neural Crest & Cranial Placodes Gordon Research Conference Development, Malformations and Cancers. 2015. |
| RAO Y., Liu A.J., Cheung M.P.L., Chan L.K., Ng I.O.L. and Cheung M.C.H., Dlc1, a Rho GTPase-activating protein, is essential for cranial neural crest development, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| RAO Y., Liu A.J., Cheung M.P.L., Chan L.K., Ng I.O.L. and Cheung M.C.H., Dlc1, a Rho GTPase-activating protein, is essential for cranial neural crest development, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| Researcher : Cheung WTL |
| Project Title: | PIK3R2 amplification in ovarian cancer: functional significance and implication for cancer therapy. |
| Investigator(s): | Cheung WTL |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2016 |
| List of Research Outputs |
| Cheung W.T.L., Editorial Board, Cancer Translational Medicine. 2016. |
| Researcher : Cheung YW |
| Project Title: | APTAMERS in Bordeaux; An Aptamer-Based Diagnostic Test Specific for Falciparum Malaria |
| Investigator(s): | Cheung YW |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2016 |
| Completion Date: | 06/2016 |
| List of Research Outputs |
| Cheung Y.W., DIRKZWAGER R.M., Cardoso J., Wong A.W.C. and Tanner J.A., An aptamer-based diagnostic test specific for Falciparum malaria, Aptamers in Bordeaux, Bordeaux, France. 2016. |
| DIRKZWAGER R.M., FRASER L.A., LIANG S., Cheung Y.W., KINGHORN A.B., Richards J.S. and Tanner J.A., DNA aptamers as antibody surrogates for molecular recognition in rapid diagnostic tests for malaria, Molecular Approaches to Malaria, Lorne, Australia. 2016. |
| DIRKZWAGER R.M., Cheung Y.W., KINGHORN A.B., FRASER L.A., LIANG S., TANG S.L.M., Kotaka M., Richards J.S. and Tanner J.A., DNA aptamers for malaria diagnosis – from crystal structure to clinical application., 40th FEBS Congress 2015 “The Biochemical Basis of Life”, Berlin, Germany (2015). 2015. |
| FRASER L.A., DIRKZWAGER R.M., LIANG S., Cheung Y.W., KINGHORN A.B., Lim B. and Tanner J.A., 3D printing aptamer based rapid diagnostic tests for the point of care diagnosis of malaria, Malaria in Melbourne (MiM), Monash University, Melbourne, Australia. 2015. |
| FRASER L.A., KINGHORN A.B., TANG S.L.M., Cheung Y.W., Lim B., LIANG S., DIRKZWAGER R.M. and Tanner J.A., Oligonucleotide Functionalised Microbeads: Indispensable Tools for High-Throughput Aptamer Selection, Molecules. 2015, 20: 21298-21312. |
| Godonoga M., Lin T.Y., Oshima A., Sumitomo K., TANG S.L.M., Cheung Y.W., KINGHORN A.B., DIRKZWAGER R.M., Zhou C., Kuzuya A., Tanner J.A. and Heddle J.G., A DNA aptamer recognising a malaria protein biomarker can function as part of a DNA origami assembly, Scientific Reports. 2016, 6: 21266. |
| SHIU C.C., Cheung Y.W., DIRKZWAGER R.M., LIANG S., KINGHORN A.B., FRASER L.A., TANG S.L.M. and Tanner J.A., Aptamer-mediated macromolecular recognition in facilitating DNA tweezer machinery, Aptamers in Bordeaux, Bordeaux, France. 2016. |
| SHIU C.C., Cheung Y.W., DIRKZWAGER R.M., LIANG S., KINGHORN A.B., FRASER L.A., TANG S.L.M. and Tanner J.A., Best Poster Prize: Aptamer-Directed DNA Tweezers, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, Chinese University of Hong Kong, Hong Kong 2016. 2016. |
| TANG S.L.M., Godonoga M., KINGHORN A.B., Cheung Y.W., Heddle J. and Tanner J.A., Aptamer-gated DNA origami nanobox for malaria detection, Aptamers in Bordeaux, Bordeaux, France. 2016. |
| TANG S.L.M., Godonoga M., KINGHORN A.B., Cheung Y.W., Heddle J. and Tanner J.A., Construction and characterization of a three-dimensional nanoscale DNA origami box functionalized by a malaria aptamer, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, Chinese University of Hong Kong, Hong Kong. 2016. |
| TANG S.L.M., Godonoga M., KINGHORN A.B., Cheung Y.W., Heddle J. and Tanner J.A., Functionalising DNA nanostructures with aptamers for molecular recognition and dynamic response, Oligo 2016 Oxford: Antisense & Therapeutic Nucleic Acids, Oxford University, United Kingdom. 2016. |
| Researcher : Ching YP |
| Project Title: | Roles of p21-activated protein kinase (Pak) 1 in the pathogenesis of liver cancer |
| Investigator(s): | Ching YP, Ng IOL, Jin D, Yau TO |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2006 |
| Project Title: | HBx oncoprotein induces chromosome instability in hepatocarcinogenesis via dysregulation of centrosome duplication regulatory protein, TAX1BP2 |
| Investigator(s): | Ching YP, Jin D |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2013 |
| Completion Date: | 10/2016 |
| Project Title: | Functional characterization of the roles of NIMA-related kinase, Nek2 in liver cancer development and metastasis |
| Investigator(s): | Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2014 |
| Completion Date: | 05/2016 |
| Project Title: | Functional characterization of the roles of NIMA-related kinase, Nek2 in liver cancer development and metastasis |
| Investigator(s): | Ching YP, Chung SK |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | The therapeutic potential of Polo-like protein kinase 4 in liver cancer |
| Investigator(s): | Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2015 |
| Project Title: | A study of the role of CDK5RAP3 in neuronal cell differentiation |
| Investigator(s): | Ching YP, Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2015 |
| Project Title: | Functional characterization of the roles of Polo-like kinase 4, Plk4 in hepatocarcinogenesis |
| Investigator(s): | Ching YP |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2016 |
| Project Title: | Characterization of novel HBx regulated gene in hepatocellular carcinoma |
| Investigator(s): | Ching YP |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2016 |
| List of Research Outputs |
| Ching Y.P., Is centrosomal kinase a good target for cancer therapy?, In: Hong Kong University of Science and Technology, Hong Kong an Diego Workshop on Signaling, 2015. Hong Kong, 2015. |
| Ching Y.P., PAK in hepatocellular carcinoma, In: Croucher Foundation, Advances in Cancer Genetic, Cell Signaling and Translational Studies, Croucher Foundation Advance Study Institute. Hong Kong, 2015. |
| Ching Y.P., The functional role of a putative tumor suppressor protein, TAX1binding protein 2(TAX1BP2) in hepatocellular carcinoma, In: State Key Laboratory for Liver Researches, State Key Laboratory for Liver Researches Symposium 2015. Hong Kong, 2015. |
| Li S.K., TANG H.C., Lau P.Y., Zhou Y. and Ching Y.P., HBx targets centrosomal protein TAX1BP2 to promote genomic instability., Cell Symposium – Human Genomics. 2015. |
| Li S.K., TANG H.C., Lau P.Y., Zhou Y. and Ching Y.P., HBx targets centrosomal protein TAX1BP2 to promote genomic instability, In: Genome Institute of Singapore, A*Star, Cell Symposium - Human Genomic, Singapore. 2015. |
| SO P.Y., Lai W.L., Ma S.K.Y. and Ching Y.P., Overexpression of CD133 Promotes Tumorigenicity and Suppresses TAX1BP2 in Hepatocellular Carcinoma, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| SO P.Y., Lai W.L. and Ching Y.P., Overexpression of CD133 Promotes Tumourigenicity and Suppresses TAX1PB2 in Hepatocellular Carcinoma, In: EMBO, EMBL Symposium: Tumour Microenvironment and Signalling. Heidelberg, Germany, 2016. |
| Xu Y.M., Wu D.D., Zheng W., Yu F.Y., Yang F., Yao Y., Zhou Y., Ching Y.P. and Lau T.Y., Proteome profiling of cadmium-induced apoptosis by antibody array analyses in human bronchial epithelial cells., Oncotarget. Impact Journals, 2015, 7: 6146-6158. |
| Researcher : Chiu J |
| List of Research Outputs |
| Chen H., Lee L., Li G., Tsao G.S.W. and Chiu J., Upregulation of glycolysis and oxidative phosphorylation in benzo[α]pyrene and arsenic-induced rat lung epithelial transformed cells, Oncotarget. 2016. |
| Researcher : Chow MZY |
| List of Research Outputs |
| WONG N.C.S., Keung W.W.Y., Chow M.Z.Y., WONG O.T. and Li R.A., Maturation of Human Pluripotent Stem Cell Derived Cardiomyocyte, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| WONG N.C.S., Chow M.Z.Y., Keung W.W.Y. and Li R.A., Maturation of hPSC-CMs in Bioenergetics driven by Oleic Acid and PPARα agonist, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| chen G., Karakilkes I., Chow M.Z.Y., Chopra A., Keung W., Chan C.W.Y., Costa K.D., Kong M.C.W., Hajjar R.J., Chen C.S. and Li R.A., Phospholamban as a crucial determinant of the inotropic response of human pluripotent stem cell-derived ventricular cardiomyocytes and engineered 3-dimensional tissue constructs., 2015, 8. |
| Researcher : Chu MT |
| List of Research Outputs |
| Chu M.T., Lee D.K.M., Wong D.P.K., Wong G.T.C. and Yue K.K.M., Methylglyoxal-induced neuroinflammatory response in in vitro astrocytic cultures and hippocampus of experimental animals, Metabolic Brain Disease. 2016. |
| HUANG C., Ng T.W., Chu M.T., Chang R.C.C. and Wong G.T.C., The relationship between tau protein phosphorylation and surgical trauma in post operative cognitive dysfunction., The 11th International Conference on Healthy Aging. 2016, 62. |
| HUANG C., Ng T.W., Chu M.T., Chang R.C.C. and Wong G.T.C., The relationship of tau protein and inflammation within cognitive dysfunction induced by laparotomy, International Alzheimer’s Disease Conference 2016. 63. |
| HUANG C., Ng T.W., Chu M.T., Chang R.C.C. and Wong G.T.C., The role of tau protein and inflammation within cognitive dysfunction induced by laparotomy in young animal. , Annual Scientific Conference of The Hong Kong Society of Neuroscience 2016. 36. |
| LEUNG W.Y.Y., Ng T.W., Cheng S.Y., Hung H.L.C., Chu M.T., Chang R.C.C. and Wong G.T.C., The effect of sevoflurane in cognition. , The 11th International Conference on Healthy Aging. 2016, 71. |
| LEUNG W.Y.Y., Ng T.W., Cheng S.Y., Hung H.L.C., Chu M.T., Chang R.C.C. and Wong G.T.C., The effect of sevoflurane in cognitive and synaptic function, International Alzheimer’s Disease Conference . 2016, 64. |
| Researcher : Chung SK |
| Project Title: | Stem Cell Strategy for Nervous System Disorders |
| Investigator(s): | Chung SK |
| Department: | Anatomy |
| Source(s) of Funding: | Theme-based Research Scheme |
| Start Date: | 09/2012 |
| Project Title: | Molecular Basis for Diabetes-induced Painless and Painful Neuropathy, and Inability to Structurally and Functionally Recovery after Peripheral Nerve Injury |
| Investigator(s): | Chung SK |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2012 |
| Completion Date: | 08/2015 |
| Project Title: | Aldose Reductase(AR) effect dopaminergic neuronal autophagy through microglia after acute inflammation in Parkinson’s disease |
| Investigator(s): | Chung SK |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2015 |
| Project Title: | To determine the role of Exchange Proteins Directly Activated by cAMP (Epac) in the gut microbiota-mediated metabolic syndrome |
| Investigator(s): | Chung SK |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2015 |
| Project Title: | Molecular basis of beta3-adrenergic receptor agonists on anxiolytic-and anti-depressive action: cAMP/Epac2 as a potential signal to improve neuronal mitochondrial biogenesis and neurogenesis. |
| Investigator(s): | Chung SK |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2016 |
| List of Research Outputs |
| FENG R., Tirrell L.S. and Chung S.K., Role of Deleted in Liver Cancer 2(DLC2) in Diabetes-associated Neuropathy, 11th International Symposium on Healthy Aging. 2016. |
| FENG R. and Chung S.K., Role of deleted in liver cancer 2(DLC2) in diabetes-associated neuropathy, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| LIU J., Chung S.K. and Lo A.C.Y., Loss of retinal microglia exacerbates vascular outcomes in mouse oxygen-induced retinopathy model, ARVO 2016 Annual Meeting. 2016. |
| LIU J., Chung S.K. and Lo A.C.Y., Quantitative Analysis of Retinal Microglia in Mouse Oxygen-induced Retinopathy Model, The 20th Research Postgraduate Symposium, LKS Faculty of Medicine, The University of Hong Kong. 2015. |
| LIU J., Chung S.K. and Lo A.C.Y., Retinal microglia behavior in mouse ocygen-induced retinopathy model: quantitation and distribution, The 6th FAONS Congress and the 11th Biennial Conference of Chinese Neuroscience Society. 2015. |
| Luo X., TAI W.L., Sun L.T., Pan Z., Xia Z., Chung S.K. and Cheung C.W., Crosstalk between astrocytic CXCL12 and microglial CXCR4 contributes to the development of neuropathic pain, 2016. |
| VIRWANI P.D., Zhou L., Wang Y. and Chung S.K., Role of Exchange Protein Directly Activated by cAMP 1 & 2 (Epac1 &Epac2) in Inflammatory Pain, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| VIRWANI P.D., Zhou L., Wang Y. and Chung S.K., Role of Exchange Protein Directly Activated by cAMP 1 & 2 (Epac1 &Epac2) in Inflammatory Pain, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| VIRWANI P.D., Zhou L., Wang Y. and Chung S.K., Role of Exchange Protein Directly Activated by cAMP 1 & 2 (Epac1& Epac2) in Inflammatory Pain, 11th International Symposium on Healthy Aging. 2016. |
| Researcher : Chung WSE |
| List of Research Outputs |
| Chan L.K., Chen J.Y. and Chung W.S.E., Dissecting the Meaning of Life: An Anthology of Essays on Body Donation, 2015. |
| Researcher : DIRKZWAGER RM |
| List of Research Outputs |
| Cheung Y.W., DIRKZWAGER R.M., Cardoso J., Wong A.W.C. and Tanner J.A., An aptamer-based diagnostic test specific for Falciparum malaria, Aptamers in Bordeaux, Bordeaux, France. 2016. |
| DIRKZWAGER R.M., FRASER L.A., LIANG S., Cheung Y.W., KINGHORN A.B., Richards J.S. and Tanner J.A., DNA aptamers as antibody surrogates for molecular recognition in rapid diagnostic tests for malaria, Molecular Approaches to Malaria, Lorne, Australia. 2016. |
| DIRKZWAGER R.M., Cheung Y.W., KINGHORN A.B., FRASER L.A., LIANG S., TANG S.L.M., Kotaka M., Richards J.S. and Tanner J.A., DNA aptamers for malaria diagnosis – from crystal structure to clinical application., 40th FEBS Congress 2015 “The Biochemical Basis of Life”, Berlin, Germany (2015). 2015. |
| DIRKZWAGER R.M., LIANG S. and Tanner J.A., Development of Aptamer-Based Point-of-Care Diagnostic Devices for Malaria Using Three-Dimensional Printing Rapid Prototyping, ACS Sensors. 2016, 1: 420-426. |
| DIRKZWAGER R.M., The Development of Aptamer-Based Technology for Point-of-Care Malaria Diagnosis, PhD Thesis, The University of Hong Kong. 2016. |
| FRASER L.A., DIRKZWAGER R.M., LIANG S., Cheung Y.W., KINGHORN A.B., Lim B. and Tanner J.A., 3D printing aptamer based rapid diagnostic tests for the point of care diagnosis of malaria, Malaria in Melbourne (MiM), Monash University, Melbourne, Australia. 2015. |
| FRASER L.A., KINGHORN A.B., TANG S.L.M., Cheung Y.W., Lim B., LIANG S., DIRKZWAGER R.M. and Tanner J.A., Oligonucleotide Functionalised Microbeads: Indispensable Tools for High-Throughput Aptamer Selection, Molecules. 2015, 20: 21298-21312. |
| Godonoga M., Lin T.Y., Oshima A., Sumitomo K., TANG S.L.M., Cheung Y.W., KINGHORN A.B., DIRKZWAGER R.M., Zhou C., Kuzuya A., Tanner J.A. and Heddle J.G., A DNA aptamer recognising a malaria protein biomarker can function as part of a DNA origami assembly, Scientific Reports. 2016, 6: 21266. |
| LIANG S., DIRKZWAGER R.M. and Tanner J.A., Rapid prototyping aptamer-enabled malaria diagnostics using three-dimensional printing, Aptamers 2016, 3rd Oxford Symposium on Aptamers, Oxford University, United Kingdom. 2016. |
| SHIU C.C., Cheung Y.W., DIRKZWAGER R.M., LIANG S., KINGHORN A.B., FRASER L.A., TANG S.L.M. and Tanner J.A., Aptamer-Directed DNA Tweezers, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, Chinese University of Hong Kong, Hong Kong. 2016. |
| SHIU C.C., Cheung Y.W., DIRKZWAGER R.M., LIANG S., KINGHORN A.B., FRASER L.A., TANG S.L.M. and Tanner J.A., Aptamer-mediated macromolecular recognition in facilitating DNA tweezer machinery, Aptamers in Bordeaux, Bordeaux, France. 2016. |
| SHIU C.C., Cheung Y.W., DIRKZWAGER R.M., LIANG S., KINGHORN A.B., FRASER L.A., TANG S.L.M. and Tanner J.A., Best Poster Prize: Aptamer-Directed DNA Tweezers, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, Chinese University of Hong Kong, Hong Kong 2016. 2016. |
| TANG S.L.M., Godonoga M., DIRKZWAGER R.M., KINGHORN A.B., Heddle J.G. and Tanner J.A., Aptamer-functionalized DNA origami: an emerging tool for malaria diagnosis, Hong Kong Inter-University Postgraduate Symposium on Life Science. 2016. |
| Researcher : DU Y |
| List of Research Outputs |
| LI T., Lian F., Xie S., DU Y. and Qian C., Molecular insights into histone H3 ubiquitination dependent maintenance DNA methylation, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Researcher : DUAN Z |
| List of Research Outputs |
| DUAN Z., Fung M.L., Wu W., Lo A.C.Y., Xia J. and Huang J., Kinesin-1 regulates extrasynaptic NMDAR targeting and its reduction can confer neuroprotection, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| DUAN Z., Fung M.L., Ni Y., Wu W., Chan Y.S. and Huang J., Kinesin-1 regulates extrasynaptic NMDAR targeting and its reduction can confer neuroprotection, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| Researcher : Deng J |
| List of Research Outputs |
| CHENG Y., GAO W., Tang H.M.V., Deng J., Wong C.M., Chan C.P. and Jin D., β-TrCP-mediated ubiquitination and degradation of liver-enriched transcription factor CREB-H, Scientific Reports. 2016, 6. |
| CHENG Y., GAO W., Tang H.M.V., Deng J., Chan C.P. and Jin D., β-TrCP-mediated ubiquitination and degradation of liver-enriched transcription, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| GAO W., Tang H.M.V., CHENG Y., Deng J., Chan C.P. and Jin D., Ubiquitination and degradation of CRTC1 transcriptional coactivator triggered by salt-inducible kinase 1-dependent phosphorylation, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Tang H.M.V., GAO W., Chan C.P., CHENG Y., Deng J., Yuen K.S., Iha H. and Jin D., SIRT1 Suppresses Human T-Cell Leukemia Virus Type 1 Transcription, Journal of Virology. 2015, 89: 8623-8631. |
| Researcher : Deng W |
| Project Title: | Role of Bmi-1 in the persistence of Epstein-Barr virus (EBV) in nasopharyngeal epithelial cells |
| Investigator(s): | Deng W, Tsao GSW, Huen MSY, Tsang CM |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 01/2013 |
| Completion Date: | 08/2016 |
| Project Title: | Role of short telomere profiles of cancer patients in determining cancer karyotype abnormalities |
| Investigator(s): | Deng W, Tsao GSW |
| Department: | School of Nursing |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2013 |
| Completion Date: | 11/2015 |
| Project Title: | Distinct whole-genome short telomere profiles of cancer patients in comparison with non-cancer individuals |
| Investigator(s): | Deng W, Tiwari AFY, Tsao GSW, Lam CLD |
| Department: | School of Nursing |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2014 |
| Completion Date: | 05/2016 |
| Project Title: | A novel function of IL-6/IL-6R?signaling activation in nasopharyngeal epithelial cells: facilitation of cellular immortalization |
| Investigator(s): | Deng W, Tsao GSW, Chen H |
| Department: | School of Nursing |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Immortalization of human uterine cervical epithelial cells without viral oncogene expression |
| Investigator(s): | Deng W, Tsao GSW |
| Department: | School of Nursing |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 03/2015 |
| List of Research Outputs |
| LIN W., Yip Y.L., LO K.W., Deng W. and Tsao G.S.W., Establishment of a new cell line of nasopharyngeal carcinoma, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| ZHANG J., Jia L.J., LIN W., Yip Y.L., Tsang C.M., Zhou Y., Zhu D., Deng W. and Tsao G.S.W., Significance of Epstein-Barr virus encoded Latent Membrane Protein 1-Induced mTOR Signaling in Nasopharyngeal Cells, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| ZHU D., ZHANG J., Deng W., Yip Y.L., Lung H.L., Tsang C.M., Law W.T., Yang J., Lau M.Y., Lung M.L., Cheung A. and Tsao G.S.W., Significance of NF-kB activation in immortalization of nasopharyngeal epithelial cells., Int. J. Cancer. 2015. |
| Researcher : FAN W |
| List of Research Outputs |
| FAN W., Huang J., Yao K.M. and Huang W., Toward exploring pluripotency landscape through light-induced tuning of Oct4 expression, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Researcher : FENG R |
| List of Research Outputs |
| FENG R., Tirrell L.S. and Chung S.K., Role of Deleted in Liver Cancer 2(DLC2) in Diabetes-associated Neuropathy, 11th International Symposium on Healthy Aging. 2016. |
| FENG R. and Chung S.K., Role of deleted in liver cancer 2(DLC2) in diabetes-associated neuropathy, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| Researcher : FRASER LA |
| List of Research Outputs |
| DIRKZWAGER R.M., FRASER L.A., LIANG S., Cheung Y.W., KINGHORN A.B., Richards J.S. and Tanner J.A., DNA aptamers as antibody surrogates for molecular recognition in rapid diagnostic tests for malaria, Molecular Approaches to Malaria, Lorne, Australia. 2016. |
| DIRKZWAGER R.M., Cheung Y.W., KINGHORN A.B., FRASER L.A., LIANG S., TANG S.L.M., Kotaka M., Richards J.S. and Tanner J.A., DNA aptamers for malaria diagnosis – from crystal structure to clinical application., 40th FEBS Congress 2015 “The Biochemical Basis of Life”, Berlin, Germany (2015). 2015. |
| FRASER L.A., DIRKZWAGER R.M., LIANG S., Cheung Y.W., KINGHORN A.B., Lim B. and Tanner J.A., 3D printing aptamer based rapid diagnostic tests for the point of care diagnosis of malaria, Malaria in Melbourne (MiM), Monash University, Melbourne, Australia. 2015. |
| FRASER L.A., KINGHORN A.B., TANG S.L.M., Cheung Y.W., Lim B., LIANG S., DIRKZWAGER R.M. and Tanner J.A., Oligonucleotide Functionalised Microbeads: Indispensable Tools for High-Throughput Aptamer Selection, Molecules. 2015, 20: 21298-21312. |
| SHIU C.C., Cheung Y.W., DIRKZWAGER R.M., LIANG S., KINGHORN A.B., FRASER L.A., TANG S.L.M. and Tanner J.A., Aptamer-Directed DNA Tweezers, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, Chinese University of Hong Kong, Hong Kong. 2016. |
| SHIU C.C., Cheung Y.W., DIRKZWAGER R.M., LIANG S., KINGHORN A.B., FRASER L.A., TANG S.L.M. and Tanner J.A., Aptamer-mediated macromolecular recognition in facilitating DNA tweezer machinery, Aptamers in Bordeaux, Bordeaux, France. 2016. |
| SHIU C.C., Cheung Y.W., DIRKZWAGER R.M., LIANG S., KINGHORN A.B., FRASER L.A., TANG S.L.M. and Tanner J.A., Best Poster Prize: Aptamer-Directed DNA Tweezers, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, Chinese University of Hong Kong, Hong Kong 2016. 2016. |
| Researcher : FUNG SW |
| List of Research Outputs |
| FUNG S.W., CHEUNG P.F.Y., YIP C.W., NG W.C., Tsao G.S.W. and CHEUNG S.T., Expression of ATP-binding cassette (ABC) transporter ABCF1 in fetal liver and liver cancer associated with cancer stem cell markers GEP, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Researcher : FUNG SY |
| List of Research Outputs |
| CHAUDHARY V., Zhang S., Yuen K.S., Li C., Lui P.Y., FUNG S.Y., WANG P., Chan C.P., Li D., Kok K.H., Liang M. and Jin D., Suppression of type I and type III interferon signalling by NSs protein of severe fever-with-thrombocytopenia syndrome virus through inhibition of STAT1 phosphorylation and activation, Journal of General Virology. 2015. |
| Chan C.P., YUEN C.K., FUNG S.Y., KEW C., Yuen K.Y., Kok K.H. and Jin D., Antagonising roles between PACT and influenza A virus polymerase subunits in viral replication and innate immune response, American Association for Immunologists Annual Meeting - Immunology 2016. |
| Chan C.P., YUEN C.K., FUNG S.Y., KEW C., Zheng B., Yuen K.Y., Kok K.H. and Jin D., Influenza A virus NS1 protein targets double stranded RNA-binding protein PACT to suppress innate antiviral response , 10th Asia-Pacific Congress of Medical Virology 2015. |
| FUNG S.Y., The American Society for Virology Travel Award: Activation of cGAS/cGAMP signaling by Sindbis virus, The American Society for Virology 34th Annual Meeting. 2015. |
| YUEN C.K., Chan C.P., FUNG S.Y., WANG P., Wong L.W.M., Tang H.M.V., Yuen K.S., Chan C.P., Jin D. and Kok K.H., Suppression of Type I Interferon Production by Human T-Cell Leukemia Virus Type 1 Oncoprotein Tax through Inhibition of IRF3 Phosphorylation, Journal of Virology. 2016, 90: 3902-3912. |
| Researcher : Fan Y |
| Project Title: | Probabilistic Modeling in Genomics Meeting; HLAassoc: tests for association between HLA alleles and diseases |
| Investigator(s): | Fan Y |
| Department: | Centre for Genomic Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 10/2015 |
| Completion Date: | 10/2015 |
| List of Research Outputs |
| CHENG Z., Chu H., Fan Y., Li C., Song Y., Zhou J. and Yuen K.Y., PExFInS: An Integrative Post-GWAS Explorer for Functional Indels and SNPs, Sci Rep. 2015, 5: 17302. |
| Researcher : Feng W |
| Project Title: | Maintenance of Genome Stability 2014; A role of NIRR in replicative stress responses |
| Investigator(s): | Feng W |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 03/2014 |
| List of Research Outputs |
| Feng W., Guo Y., Huang J., Deng Y., Zang J. and Huen M.S.Y., TRAIP regulates replication fork recovery and progression via PCNA. Cell Discovery, Cell Discovery. 2016. |
| GUO Y., Feng W., Sy M.H. and Huen M.S.Y., ATM-dependent Phosphorylation of the Fanconi Anemia Protein PALB2 Promotes the DNA Damage Response, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Guo Y., Feng W., Sy M.H. and Huen M.S.Y., ATM-dependent phosphorylation of the Fanconi anemia protein PALB2 promotes the DNA Damage Response, Journal of Biological Chemistry. 2015, jbc.M115.672626. |
| Researcher : Fu C |
| Project Title: | Systematic investigation of the roles of mitotic kinesins in spindle dynamics |
| Investigator(s): | Fu C |
| Department: | Biochemistry |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2013 |
| Project Title: | Roles of a novel spindle pole body protein psr1p in bipolar spindle assembly and kinetochore clustering |
| Investigator(s): | Fu C |
| Department: | Biochemistry |
| Source(s) of Funding: | Early Career Scheme (ECS) |
| Start Date: | 12/2013 |
| Completion Date: | 12/2015 |
| Project Title: | The role of Cdk1 mediated phosphorylation of the CENP-A chaperone Scm3p in mitosis |
| Investigator(s): | Fu C |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 03/2015 |
| Project Title: | Molecular mechanisms of nuclear congression |
| Investigator(s): | Fu C |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2016 |
| Researcher : Fung ML |
| Project Title: | Protective effect of Lycium barbarum polysaccharides on spatial memory deficits induced by intermittent hypoxia in rats |
| Investigator(s): | Fung ML |
| Department: | Physiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | Pathophysiological role of nitric oxide deficit in the carotid body function in intermittent hypoxia |
| Investigator(s): | Fung ML |
| Department: | Physiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 03/2015 |
| List of Research Outputs |
| DUAN Z., Fung M.L., Wu W., Lo A.C.Y., Xia J. and Huang J., Kinesin-1 regulates extrasynaptic NMDAR targeting and its reduction can confer neuroprotection, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| DUAN Z., Fung M.L., Ni Y., Wu W., Chan Y.S. and Huang J., Kinesin-1 regulates extrasynaptic NMDAR targeting and its reduction can confer neuroprotection, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| Fung M.L., Angiotensin II in the carotid body – a friend or foe?, Experimental Physiology. 2016, 101(6): 675-676. |
| Fung M.L., Nitric oxide deficit is part of the maladaptive paracrine-autocrine response of the carotid body to intermittent hypoxia in sleep apnea, Advances in Experimental Medicine & Biology: Arterial Chemoreceptors Edited by Chris Peers, Prem Kumar. New York, Springer, 2015, 860: 233-237. |
| Kang J.J., Liang W.H., LAM C.S., Huang X.F., Yang S.J., MT W.O.N.G.-.R.I.L.E.Y., Fung M.L. and Liu Y.Y., Catecholaminergic neurons in synaptic connections with pre-Botzinger complex neurons in the rostral ventrolateral medulla in normoxic and daily acute intermittent hypoxic rats., Experimental Neurology In Press. 2016. |
| LAM C.S., Lee M.K.Y., Mak J.C.W., Fung A.C.H., Tipoe G.L. and Fung M.L., Chronic intermittent hypoxia exacerbates depressive-like behaviors in high fat diet-fed mice. The 19th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, Journal of the Hong Kong College of Cardiology. 2015, 23(2): 97, CP5. |
| LAM C.S., LI J., LIU Y.Y., Tipoe G.L. and Fung M.L., Maladaptive up-regulation of brain monoamine oxidase-A contributes to depressive-like behavior in a rat model of obstructive sleep apnea, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| LAM C.S., LI J., Tipoe G.L. and Fung M.L., Maladaptive up-regulation of brain monoamine oxidase-A contributes to depressive-like behaviors in a rat model of obstructive sleep apnea, 20th Research Postgraduate Symposium, HKU. 2015, P3.3. |
| LAM C.S., Lee M.K.Y., Mak J.C.W., Ip M.S.M., Fung A.C.H., Tipoe G.L. and Fung M.L., Mechanistic roles of monoamine oxidase A in the exacerbative effect of chronic intermittent hypoxia on the depressive-like behavior in the mice model of diet-induced obesity. The Eleventh Eleventh International Symposium on Healthy Aging – Science and Aging, An Era of Discovery, OP3. 2016. |
| LAM C.S., Tipoe G.L., Wong K.C., Youdim M.B.H. and Fung M.L., Multifunctional drug M30 mitigates neurodegeneration and depressive-like behaviors induced by corticosterone in rats. Hong Kong Inter-University Postgraduate Symposium, Biochemical Sciences. 2016. |
| LAM C.S., Tipoe G.L., Wong K.C., Youdim M.B.H. and Fung M.L., Multifunctional drug M30 mitigates neurodegeneration and depressive-like behaviors induced by corticosterone in rats, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| LAM C.S., Tipoe G.L., So K.F. and Fung M.L., Polysaccharides antagonized rat hippocampal-dependent spatial memory deficits induced by chronic intermittent hypoxia. First Exchange Camp for Biomedical Research Students in Guangdong, Hong Kong and Macau, Lycium barbarum. 2015. |
| LI J., LAM C.S., Tipoe G.L. and Fung M.L., Increased MAO-A Expression Mediated by Norepinephrine Plays a Role in Intermittent Hypoxia-induced Oxidative Stress and Cell Death in SH-SY5Y Cells, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| LI J., LAM C.S., Tipoe G.L. and Fung M.L., Increased MAO-A expression mediated by norepinephrine plays a role in intermittent hypoxia-induced oxidative stress and cell death in SH-SY5Y cells, 20th Research Postgraduate Symposium, HKU. 2015, P3.06. |
| LI J., LAM C.S., Tipoe G.L. and Fung M.L., Norepinephrine increases the monoamine oxidase-A and oxidative stress in SH-SY5Y cells. The 19th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, Journal of the Hong Kong College of Cardiology. 2015, 23(2): 95, CP1. |
| LI J., LAM C.S., Tipoe G.L. and Fung M.L., Upregulated biosynthesis of Norepinephrine and MAOA expression mediates the oxidative stress and cell death in SH-SY5Y cells, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| LI J., LAM C.S., Tipoe G.L. and Fung M.L., Upregulated biosynthesis of norepinephrine and MAOA expression mediates the oxidative stress and cell death in SH-SY5Y cells. The Eleventh International Symposium on Healthy Aging, Science and Aging: An Era of Discovery. 2016, P47. |
| Researcher : GAO W |
| List of Research Outputs |
| CHENG Y., GAO W., Tang H.M.V., Deng J., Wong C.M., Chan C.P. and Jin D., β-TrCP-mediated ubiquitination and degradation of liver-enriched transcription factor CREB-H, Scientific Reports. 2016, 6. |
| CHENG Y., GAO W., Tang H.M.V., Deng J., Chan C.P. and Jin D., β-TrCP-mediated ubiquitination and degradation of liver-enriched transcription, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| GAO W., Tang H.M.V., CHENG Y., Deng J., Chan C.P. and Jin D., Ubiquitination and degradation of CRTC1 transcriptional coactivator triggered by salt-inducible kinase 1-dependent phosphorylation, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Jin D., Tang H.M.V., GAO W., Chan C.P., Iha H. and Yuen K.S., Suppression of HTLV-1 transcription by SIRT1 deacetylase, Retrovirology. 2015, 12: P53. |
| Siu C.W.K., Lam C.W., Gao W., Tang H.M.V., Jin D. and Mak C.M., Unmasking a novel disease gene NEO1 associated with autism spectrum disorders by a hemizygous deletion on chromosome 15 and a functional polymorphism, Behavioural Brain Research. 2016, 300: 135-142. |
| Researcher : GHOSH S |
| List of Research Outputs |
| GHOSH S., Liu B., Wang Y., Hao Q. and Zhou Z., Lamin A Is an Endogenous SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair, Cell Reports. 2015, 13: 1396-1406. |
| IEONG I.L., GHOSH S. and Zhou Z., Post-translational modifications of KAP1 and its biological relevance, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Researcher : GUO S |
| List of Research Outputs |
| GUO S., Tsang K.Y., Au Y.K., Tam W.K., Leung V.Y.L. and Cheah K.S.E., Generation of a Chordoma Cell Line: a Model of Human Notochordal Cells?, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Researcher : GUO Y |
| List of Research Outputs |
| Feng W., Guo Y., Huang J., Deng Y., Zang J. and Huen M.S.Y., TRAIP regulates replication fork recovery and progression via PCNA. Cell Discovery, Cell Discovery. 2016. |
| GUO Y., Feng W., Sy M.H. and Huen M.S.Y., ATM-dependent Phosphorylation of the Fanconi Anemia Protein PALB2 Promotes the DNA Damage Response, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Guo Y., Feng W., Sy M.H. and Huen M.S.Y., ATM-dependent phosphorylation of the Fanconi anemia protein PALB2 promotes the DNA Damage Response, Journal of Biological Chemistry. 2015, jbc.M115.672626. |
| Researcher : Gao B |
| Project Title: | Characterize the in vivo functional significance of Vangl2 phosphorylation in Planar Cell Polarity (PCP) |
| Investigator(s): | Gao B |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2015 |
| Project Title: | 中國生理學會基質生物學專業委員會成立大會 暨第一次全國基質生物學學術會議; Global Directional Cues in Establishing Planar Cell Polarity During Long Bone Development |
| Investigator(s): | Gao B |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 03/2016 |
| Completion Date: | 03/2016 |
| Project Title: | Identifying the genetic variants underlying carpal tunnel syndrome in a big family |
| Investigator(s): | Gao B, Song Y |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2016 |
| List of Research Outputs |
| Gao B., Global Directional Cues in Establishing Planar Cell Polarity During Long Bone Development, Inaugural Conference of Chinese Society of Matrix Biology (CSMB). 第一次全國基質生物學學術 會議, 2016. |
| Gao B., Wnt regulation of Planar Cell Polarity , South University of Science and Technology of China (SUSTC) Life Science Seminar. 2016. |
| Researcher : Gao W |
| List of Research Outputs |
| CHENG Y., GAO W., Tang H.M.V., Deng J., Wong C.M., Chan C.P. and Jin D., β-TrCP-mediated ubiquitination and degradation of liver-enriched transcription factor CREB-H, Scientific Reports. 2016, 6. |
| CHENG Y., GAO W., Tang H.M.V., Deng J., Chan C.P. and Jin D., β-TrCP-mediated ubiquitination and degradation of liver-enriched transcription, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| GAO W., Tang H.M.V., CHENG Y., Deng J., Chan C.P. and Jin D., Ubiquitination and degradation of CRTC1 transcriptional coactivator triggered by salt-inducible kinase 1-dependent phosphorylation, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Jin D., Tang H.M.V., GAO W., Chan C.P., Iha H. and Yuen K.S., Suppression of HTLV-1 transcription by SIRT1 deacetylase, Retrovirology. 2015, 12: P53. |
| Siu C.W.K., Lam C.W., Gao W., Tang H.M.V., Jin D. and Mak C.M., Unmasking a novel disease gene NEO1 associated with autism spectrum disorders by a hemizygous deletion on chromosome 15 and a functional polymorphism, Behavioural Brain Research. 2016, 300: 135-142. |
| Researcher : HAU WF |
| List of Research Outputs |
| HAU W.F., Chan Y.S. and Shum D.K.Y., Change in sulfation patterns of chondroitin associated with the plastic changes in the rat brainstem [HK. March 12-13, 2016], Abstracts of 11th Int’l Symp. on Healthy Aging: Science and Aging – An Era of Discovery. 2016, 68. |
| HAU W.F., Chan Y.S. and Shum D.K.Y., Differential sulfation of chondroitins in the brain extracellular matrix regulates neuroplasticity, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| HAU W.F., Chan Y.S. and Shum D.K.Y., Dynamics of chondroitin sulfation in the rat brain during development and vestibular compensation, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| Shum D.K.Y., HAU W.F., Ma C.W. and Chan Y.S., Modulating sulfation of perineuronal chondroitins during vestibular compensatin [Seoul, Korea. Aug. 23-27, 2015], Proc. 9th InternationalConference on Proteoglycans & 10th Pan-Pacific Connective Tissue Societies Symposium. 2015. |
| Researcher : HO CC |
| List of Research Outputs |
| HO C.C., Wang B., Wong Y.M.E., LIU Y., Hui C.C. and Sham M.H., Best Poster Award: Sufu regulates the cell cycle exit and differentiation of cochlear hair cell progenitors, 2016 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, CUHK, Hong Kong, June 11, 2016. . 2016. |
| HO C.C., Wang B., Wong Y.M.E., LIU Y., HUI C.C. and Sham M.H., Sufu regulates the cell cycle exit and differentiation of cochlear hair cell progenitors, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Researcher : HO TH |
| List of Research Outputs |
| HO T.H., American Society for Virology Travel Award: A vaccine strain of Measles virus produces a copy-back type defective-interfering RNA that potently activates innate antiviral response through RIG-I and PACT, The American Society for Virology 34th Annual Meeting. 2015. |
| HO T.H., KEW C., LUI P.Y., Chan C.P., Satoh T., Akira S., Jin D. and Kok K.H., PACT- and RIG-I-Dependent Activation of Type I Interferon Production by a Defective Interfering RNA Derived from Measles Virus Vaccine, Journal of Virology. 2016, 90: 1557-1568. |
| Researcher : HU M |
| List of Research Outputs |
| HU M. and Hao Q., Immunoglobulin-like domains of PECAM-1 contribute to trans-homophilic interaction, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Researcher : HU Q |
| List of Research Outputs |
| HU Q., Wong D.S.H. and Boheler K.R., Utilizing Human Pluripotent Stem Cell-derived RPE cells as therapeutic intervention of AMD, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Researcher : HUANG Y |
| List of Research Outputs |
| NG H.L.L., HUANG Y., Chang R.C.C. and Lai S.W.C., Altered Dendritic Spine Plasticity in a Mouse Depression Model, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| NG H.L.L., HUANG Y., Chang R.C.C. and Lai S.W.C., Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences, Altered dendritic spine plasticity in a mouse depression model. 2016. |
| Researcher : HUNG CH |
| List of Research Outputs |
| HUNG C.H. and Cheung K.H., Role of Intracellular Calcium Release Channels in Asthma Pathogenesis, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| LEE S.K., TONG C.K.B., CHENG W.H., HUNG C.H. and Cheung K.H., Characterization of Two-Pore Channel 2 by Nuclear Membrane Electrophysiology, Scientific Reports. 2016, 6: 20282. |
| Researcher : Han L |
| Project Title: | Postsynaptic plasticity: Differential roles of inhibitory and excitatory vestibular nuclear neurons |
| Investigator(s): | Han L, Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2015 |
| List of Research Outputs |
| Cai S., Han L., Ao Q., Chan Y.S. and Shum D.K.Y., Induced pluripotent stem cell-derived sensory neurons for fate commitment of bone marrow-derived Schwann cells – Utilization in re-myelination therapy , Stem Cells Translational Medicine. 2016, 5: 1-13. |
| Cai S., Han L., Chan Y.S. and Shum D.K.Y., Small molecule approach to differentiation of human induced pluripotent stem cells to sensory neurons, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| Chan Y.S., Han L., Li Y.H., Ma C.W. and Shum D.K.Y., Role of G-protein-coupled serotonin receptor on synaptic plasticity of excitatory transmission in the vestibular nucleus of rats ( USA) 236.03/L22 [Chicago. Oct. 15-19, 2015], Soc. Neuroscience Abstract. 2015. |
| Han L., Yanagawa Y., Lai S.W.C. and Chan Y.S., Manipulation of different cortical neuron subtypes with optogenetics [HK. May 18, 2016], Proc. Neuroscience Symposium 2016 & Scientific Conference of The Hong Kong Society of Neurosciences. 2016, 34. |
| Han L., Yanagawa Y., Lai S.W.C. and Chan Y.S., Manipulation of different cortical neuron subtypes with optogenetics, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| Han L., Yanagawa Y. and Chan Y.S., Selective expression of functional light-gated ion channel in neural circuits [HK. March 12-13, 2016], Abstracts of 11th Int’l Symp. on Healthy Aging: Science and Aging – An Era of Discovery. 2016, 71. |
| Shum D.K.Y., Cai S., Han L. and Chan Y.S., Small molecule approach to direct differentiation of human induced pluripotent stem cells to sensory neurons 665.18/B44. [Chicago. Oct. 15-19, 2015], Soc. Neuroscience Abstract (USA). 2015. |
| Researcher : Hao Q |
| Project Title: | Structural Biology of Human PECAM-1 (CD31) in Cell Adhesion and Leukocyte Transmigration |
| Investigator(s): | Hao Q, Zhang H |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2012 |
| Completion Date: | 10/2015 |
| Project Title: | Investigation of pathogenesis mechanism of two infectious fungi Penicillium marneffei and Aspergillus fumigatus |
| Investigator(s): | Hao Q |
| Department: | Physiology |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2014 |
| Project Title: | Structure and Function of Human SIRT4 |
| Investigator(s): | Hao Q |
| Department: | Physiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 03/2015 |
| Project Title: | Novel Structure and Function of Human Sirtuins |
| Investigator(s): | Hao Q, Huang J, Li XD |
| Department: | Physiology |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 03/2015 |
| Project Title: | Structural study of NDM-1: Towards rational inhibitor design against the antibiotic resistant “superbug” |
| Investigator(s): | Hao Q |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 05/2016 |
| List of Research Outputs |
| GHOSH S., Liu B., Wang Y., Hao Q. and Zhou Z., Lamin A Is an Endogenous SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair, Cell Reports. 2015, 13: 1396-1406. |
| HU M. and Hao Q., Immunoglobulin-like domains of PECAM-1 contribute to trans-homophilic interaction, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Hao Q., De novo phasing with optimized XFEL data , IUCrJ. 2016, 3: 161-162. |
| Hao Q., Structural Studies of “Erasers” for Post-Translational Modifications, CSRC-RIKEN Workshop on Kinetics of Enzymes and Molecular Machines, Beijing, China. 2015. |
| Hao Q., Structural Studies of “Erasers” for Post-Translational Modifications, The 3rd Structural Biology Symposium of South of China, Xiamen, China. 2015. |
| Hao Q., 迎接硬X射线自由电子激光：挑战结构生物学极限, at The International Workshop on Shanghai X-ray Free Electron Laser, Shanghai, China. 2016. |
| Li T., Qi S., Unger M., Hou Y.N., Deng Q.W., Liu J., Lam M.C., Wang X.W., Xin D., Zhang P., Koch-Nolte F., Hao Q., Zhang H., Lee H.C. and Zhao Y.J., Immuno-targeting the multifunctional CD38 using nanobody, Scientific Reports. 2016, 6: 27055. |
| Ting K.Y., Leung C.F.P., Graeff R.M., Lee H.C., Hao Q. and Kotaka M., Porcine CD38 exhibits prominent secondary NAD + cyclase activity , Protein Science. 2015, n/a-n/a. |
| Tong Z., Wang Y., Zhang X.Y., Kim D.D., Sadhukhan S., Hao Q. and Lin H.N., SIRT7 Is Activated by DNA and Deacetylates Histone H3 in the Chromatin Context, ACS Chemical Biology. 2016, 11: 742-747. |
| Researcher : Ho JWY |
| List of Research Outputs |
| Ho J.W.Y., Kwok D., Yao K.M., Chan L.K. and Ho J., Breathing life into the concepts of biochemistry – From bedside to benchside, Frontiers in Medical and Health Sciences Education. 2015. |
| Ho J.W.Y., Faculty Teaching Medal, LKS Faculty Of Medicine Hku. 2015. |
| Ho J.W.Y., Yao K.M., Song Y., Chan L.K., Cook S. and Bridges S.M., Teaching Development Grant, The University Of Hong Kong. 2015. |
| YE L., Wong N.S. and Ho J.W.Y., Development of a Prototype Biochemistry Virtual Laboratory: Reflections on the Instructional Design, 5th Annual International Conference on Education & e-Learnning. 2015, 85-90. |
| Researcher : Ho YS |
| List of Research Outputs |
| HUANG C., Ho Y.S., Ng T.W., Irwin M.G., Chang R.C.C. and Wong G.T.C., Effect of continuous propofol infusion to rat on tau phosphorylation with or without temperature control., Journal of Alzheimer's Disease. 2016, 51: 213-226. |
| Ho Y.S., Tung C.Y. and Chang R.C.C., A pilot study on the awareness and help seeking preferences of middle-aged Chinese carers towards dementia in Hong Kong. , The 11th International Conference on Healthy Aging. 2016, 67. |
| Poon C.H., Ho Y.S., YOU R., Tse J., Chiu K. and Chang R.C.C., PKR deficiency alters E. coli-induced sickness behaviors but does not exacerbate neuroimmune responses or bacterial load., Journal of Neuroinflammation. 2015, 12: 1-19. |
| Poon D.C.H., Ho Y.S., Lau C.F. and Chang R.C.C., Oral feeding of minocycline attenuates glial activation and reductions of tau and drebrin in response to systematically injected cytokines. , Hong Kong Medical Journal. 2016, 22 Suppl.3: 16-21. |
| YOU R., Cheng S.Y., Hung H.L.C., Ho Y.S., Lai S.W.C. and Chang R.C.C., Investigating the effects of silica nanoparticles on affective and cognitive behaviors and on synapse in vivo and in vitro. , International Alzheimer’s Disease Conference 2016. 64. |
| YOU R., Cheng S.Y., Hung H.L.C., Ho Y.S. and Chang R.C.C., Investigating the impact of Silica Nanoparticles on affective and cognitive behaviors, and on synapse in vivo and in vitro. , The 11th International Conference on Healthy Aging. 2016, 61. |
| Researcher : Huang J |
| Project Title: | RNA-DNA hybrid oligonucleotide mediated site-specific repair and gene therapy |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Matching Fund for Hi-Tech Research and Development Program of China (863 Projects) |
| Start Date: | 01/2003 |
| Project Title: | Development of a Pan-organism Riboregulator Device |
| Investigator(s): | Huang J, Jin Y |
| Department: | Biochemistry |
| Source(s) of Funding: | Innovation and Technology Support Programme (Tier 3) |
| Start Date: | 11/2009 |
| Project Title: | Development of a Pan-organism Riboregulator Device |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 12/2009 |
| Project Title: | Role of kinesin-1 in NMDAR trafficking and cerebral ischemia |
| Investigator(s): | Huang J, Lin R |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2012 |
| Completion Date: | 11/2015 |
| Project Title: | Guiding the immune response: a novel approach for HIV-1 vaccine development |
| Investigator(s): | Huang J, Zhang M |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2013 |
| Completion Date: | 12/2015 |
| Project Title: | Outstanding Research Student Supervisor Award 2011-12 |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Outstanding Research Student Supervisor Award |
| Start Date: | 01/2013 |
| Project Title: | Protein Trafficking: Mechanism and Diseases |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 04/2013 |
| Project Title: | Non-canonical role of Kif5b in clathrin uncoating and the endocytic regulation of muscarinic acetylcholine receptors |
| Investigator(s): | Huang J, Ni Y |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2013 |
| Project Title: | A Generic Mechanism for Pattern Formation: From Theoretical Physics To Synthetic Biology |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | France/Hong Kong Joint Research Scheme - Travel Grants |
| Start Date: | 01/2014 |
| Project Title: | Pattern formation by bacteria: from theoretical physics to synthetic biology |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | ANR / RGC Joint Research Scheme |
| Start Date: | 01/2015 |
| Project Title: | In vivo delivery and expression of shRNA targeting SKI and SI9 by Salmonella to tumours |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | SFC / RGC Joint Research Scheme |
| Start Date: | 01/2015 |
| Completion Date: | 12/2015 |
| Project Title: | A feasibility study on the inhibition of Staphylococcus aureus infection using AdsA specific antibodies |
| Investigator(s): | Huang J, Chen Z |
| Department: | Biochemistry |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2015 |
| Project Title: | Biochemical and biophysical characterization of Kif5b cargo binding domain |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2015 |
| Project Title: | Development of antibodies against Staphylococcus aureus infection |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Translational and Applied Research |
| Start Date: | 06/2015 |
| Completion Date: | 12/2016 |
| Project Title: | Doris Zimmern HKU-Cambridge Hughes Hall Fellowships 2015-16 |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Doris Zimmern HKU-Cambridge Hughes Hall Fellowships |
| Start Date: | 09/2015 |
| Project Title: | the 9th Vaccine & ISV Congress; Recombinant ESAT‐6‐like proteins provoke protective immune responses against invasive Staphylococcus aureus disease in a murine model |
| Investigator(s): | Huang J |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 10/2015 |
| Completion Date: | 10/2015 |
| Project Title: | Characterization of the interaction between Kif5b and NMDAR in ischemic provoked neurodegeneration |
| Investigator(s): | Huang J, Sze KH |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2016 |
| Project Title: | Outstanding Researcher Award 2014-15 |
| Investigator(s): | Huang J |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Outstanding Researcher Award |
| Start Date: | 02/2016 |
| Project Title: | Salmonella-induced host innate immunity against cancer metastasis |
| Investigator(s): | Huang J |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2016 |
| List of Research Outputs |
| CHAN H.L., Huang J. and Lai K.O., The Kinesin motor protein KIF5B regulates RNA trafficking and dendritic spine morphogenesis in hippocampal neuron, HKU State Key Laboratory Neuroscience Symposium 2016 and Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| CHAN H.L., Huang J. and Lai K.O., The Kinesin motor protein KIF5B regulates RNA trafficking and dendritic spine morphogenesis in hippocampal neuron, Inter-University Postgraduate Symposium in Biochemical Sciences . 2016. |
| CHAN H.L., Huang J. and Lai K.O., The kinesin motor protein KIF5B regulates RNA trafficking and dendritic spine morphogenesis in hippocampal neuron, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| CHAN H.L., Huang J. and Lai K.O., The kinesin motor protein KIF5B regulates RNA trafficking and dendritic spine morphologenesis in hippocampal neuron, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| Cui J., Jin G.X., Yu B., Wang Z., Lin R.Z. and Huang J., Stable knockdown of Kif5b in MDCK cells leads to epithelial–mesenchymal transition, Biochemical and Biophysical Research Communications. 2015, 463: 123-129. |
| DUAN Z., Fung M.L., Wu W., Lo A.C.Y., Xia J. and Huang J., Kinesin-1 regulates extrasynaptic NMDAR targeting and its reduction can confer neuroprotection, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| DUAN Z., Fung M.L., Ni Y., Wu W., Chan Y.S. and Huang J., Kinesin-1 regulates extrasynaptic NMDAR targeting and its reduction can confer neuroprotection, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| FAN W., Huang J., Yao K.M. and Huang W., Toward exploring pluripotency landscape through light-induced tuning of Oct4 expression, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Guo Z., Yu B., Ning B.T., Chan S., Lin Q., Li C.B., Huang J. and Chan G.C.F., Genetically modified "obligate" anaerobic Salmonella typhimurium as a therapeutic strategy for neuroblastoma, Journal of Hematology & Oncology. 2015, 8. |
| LIU L., ZHAO Y. and Huang J., Precise Control of Gene Expression via Synthetic Gene Circuits, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| LIU L., ZHAO Y.F. and Huang J., Precise Control of Gene Expression via Synthetic Gene-Circuits, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Shi L., Yu B., Cai C.H., Huang W., Zheng B., Smith D.K. and Huang J., Combined prokaryotic–eukaryotic delivery and expression of therapeutic factors through a primed autocatalytic positive-feedback loop, Journal of Controlled Release. 2016, 222: 130-140. |
| TANG X., CAO T., ZHU Y., ZHANG L., CHEN J., Guan X. and Huang J., A positive feedback loop between PIM2 and TNFα contributes to hepatocellular carcinoma tumorigenesis and progression, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Tang Z., Liu L.F., Li Y.L., Dong J.Y., Li M., Huang J., Lin S.H. and Cai Z.W., Urinary Metabolomics Reveals Alterations of Aromatic Amino Acid Metabolism of Alzheimer’s Disease in the Transgenic CRND8 Mice, Current Alzheimer Research. 2016, 13: 764-776. |
| Researcher : Huang W |
| List of Research Outputs |
| FAN W., Huang J., Yao K.M. and Huang W., Toward exploring pluripotency landscape through light-induced tuning of Oct4 expression, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Researcher : Huen MSY |
| Project Title: | Role of ATM Signaling in PALB2-dependent Homologous Recombination DNA Repair |
| Investigator(s): | Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | Early Career Scheme (ECS) |
| Start Date: | 10/2012 |
| Completion Date: | 09/2015 |
| Project Title: | Study of the PALB2-Plk1 module in Cell Cycle Checkpoint Control and Maintenance of Genome Stability |
| Investigator(s): | Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2014 |
| Project Title: | Study Role of PCNA-binding protein TRAIP in Replicative Stress Responses and Tumor Suppression |
| Investigator(s): | Huen MSY, Feng W |
| Department: | Anatomy |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2014 |
| Project Title: | Examining Negative Regulatory Mechanisms of DNA Damage Signal Transduction & Their Impact on Maintenance of Genome Stability |
| Investigator(s): | Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Role of UBE2U in DNA Damage Signaling and Repair |
| Investigator(s): | Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2015 |
| Project Title: | Genomic Integrity - Zing Conferences; Towards defining chromatin dynamics at DNA double-strand breaks |
| Investigator(s): | Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2015 |
| Completion Date: | 08/2015 |
| Project Title: | Role of Human Ubiquitin Machineries in DNA Damage Signaling and Repair |
| Investigator(s): | Huen MSY |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2016 |
| Project Title: | Outstanding Young Researcher Award 2014-15 |
| Investigator(s): | Huen MSY |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Outstanding Young Researcher Award |
| Start Date: | 02/2016 |
| Project Title: | Exploiting the potential of cyro-EM for structure-based drug design: Targeting ATM for therapeutic intervention in cancer and degenerative diseases |
| Investigator(s): | Huen MSY, Lau CYW |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Translational and Applied Research |
| Start Date: | 06/2016 |
| Project Title: | Role of HAUSP in DNA Damage Signal Transduction |
| Investigator(s): | Huen MSY |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2016 |
| List of Research Outputs |
| AN L., JIANG Y., Ng H.W.H., CHEN J., GONG Q. and Huen M.S.Y., USP7 Enforces RNF169-dependent DNA Double-Strand Break Responses, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Feng W., Guo Y., Huang J., Deng Y., Zang J. and Huen M.S.Y., TRAIP regulates replication fork recovery and progression via PCNA. Cell Discovery, Cell Discovery. 2016. |
| GUO Y., Feng W., Sy M.H. and Huen M.S.Y., ATM-dependent Phosphorylation of the Fanconi Anemia Protein PALB2 Promotes the DNA Damage Response, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Guo Y., Feng W., Sy M.H. and Huen M.S.Y., ATM-dependent phosphorylation of the Fanconi anemia protein PALB2 promotes the DNA Damage Response, Journal of Biological Chemistry. 2015, jbc.M115.672626. |
| Huen M.S.Y. and Chen J., H1 provides the missing link, Cell Research. 2016, 26: 5-6. |
| Huen M.S.Y., Self-Restraining Mechanisms of DNA Damage Surveillance and Repair, IAS Focused Program on Genome Damage and Stability. 2015. |
| Huen M.S.Y., Ubiquitin Machineries in DNA Damage Responses, Hong Kong - San Diego Workshop On Signaling. 2015. |
| Huen M.S.Y., Ubiquitin Machineries in DNA Damage Responses, UNIST, Korea. 2015. |
| Lau C.Y.W., Li Y., Zhang Q. and Huen M.S.Y., Molecular architecture of the Ub-PCNA/Pol η complex bound to DNA, Scientific Reports. 2015, 5: 15759. |
| Lau C.Y.W., Zhang Q., Gao Y., Liu Z., Li Y. and Huen M.S.Y., Structure of the human dimeric ATM kinase, Cell Cycle. 2016, 15: 1117-1124. |
| NG H.M., WEI L.Z., LAN L. and Huen M.S.Y., The K63-Deubiquitylating Enzyme BRCC36 Limits DNA Break Processing and Repair, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Researcher : Hui CC |
| List of Research Outputs |
| HO C.C., Wang B., Wong Y.M.E., LIU Y., Hui C.C. and Sham M.H., Best Poster Award: Sufu regulates the cell cycle exit and differentiation of cochlear hair cell progenitors, 2016 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, CUHK, Hong Kong, June 11, 2016. . 2016. |
| LIANG Y., Wong Y.M.E., LIU Y., Krauss R.S., Xu P.X., Hui C.C. and Sham M.H., The role of Hedgehog receptor Cdo in controlling cochlear hair cell and pillar cell formation, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| LIANG Y., Wong Y.M.E., LIU Y., Hui C.C. and Sham M.H., The role of Hedgehog receptor Cdo in controlling cochlear hair cell and pillar cell formation, Hong Kong Inter-University Postgraduate symposium in Biochemical Sciences 2016. |
| LIU Y., Wang B., Wong Y.M.E., Hui C.C. and Sham M.H., The roles of Irx3 and Irx5 genes in inner ear patterning, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Researcher : Hung HLC |
| List of Research Outputs |
| CHENG S.Y., Hung H.L.C. and Chang R.C.C., Differential roles of the ubiquitin-proteasome system and autophagy in experimental models of Alzheimer’s Disease, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| Chang R.C.C., Cheng S.Y. and Hung H.L.C., Investigating protein degradation pathways in Alzheimer’s disease, International Alzheimer's Disease Conference. 2016, 24. |
| Cheng S.Y., Hung H.L.C. and Chang R.C.C., Differential roles of the ubiquitin-proteasome system and autophagy in experimental models of Alzheimer’s disease. , Annual Scientific Conference of The Hong Kong Society of Neuroscience 2016. 23. |
| Hung H.L.C., Cheng S.Y., Lee S.M.Y. and Chang R.C.C., The dynamic mitochondria network in neurodegeneration., Annual Scientific Conference of The Hong Kong Society of Neuroscience 2016. 25. |
| Hung H.L.C., Cheng S.Y., Lee S.M.Y. and Chang R.C.C., The dynamic mitochondrial network in Alzheimer’s disease, International Alzheimer’s Disease Conference 2016. 62. |
| LEUNG W.Y.Y., Ng T.W., Cheng S.Y., Hung H.L.C., Chu M.T., Chang R.C.C. and Wong G.T.C., The effect of sevoflurane in cognition. , The 11th International Conference on Healthy Aging. 2016, 71. |
| LEUNG W.Y.Y., Ng T.W., Cheng S.Y., Hung H.L.C., Chu M.T., Chang R.C.C. and Wong G.T.C., The effect of sevoflurane in cognitive and synaptic function, International Alzheimer’s Disease Conference . 2016, 64. |
| Man I.S.C., Hung H.L.C., Lee S.M.Y. and Chang R.C.C., Investigation of drugs targeting mitochondrial dynamics and reactive oxygen species for Parkinson’s disease treatment. , The 11th International Conference on Healthy Aging. 2016, 62. |
| SHAH A.N., Hung H.L.C., CHENG S.Y. and Chang R.C.C., The effect of Oxyresveratrol on endoplasmic reticulum stress in Parkinson’s disease, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| SHAH A.N., Hung H.L.C., Cheng S.Y. and Chang R.C.C., The effect of oxyresveratrol on endoplasmic reticulum stress in Parkinson’s disease., Annual Scientific Conference of The Hong Kong Society of Neuroscience 2016. 50. |
| SHAH A.N., Hung H.L.C., Cheng S.Y. and Chang R.C.C., The role of oxyresveratrol in mitigating cellular toxicity in Parkinson’s disease, The 11th International Conference on Healthy Aging. 2016, 63. |
| YOU R., Cheng S.Y., Hung H.L.C., Ho Y.S., Lai S.W.C. and Chang R.C.C., Investigating the effects of silica nanoparticles on affective and cognitive behaviors and on synapse in vivo and in vitro. , International Alzheimer’s Disease Conference 2016. 64. |
| YOU R., Cheng S.Y., Hung H.L.C., Ho Y.S. and Chang R.C.C., Investigating the impact of Silica Nanoparticles on affective and cognitive behaviors, and on synapse in vivo and in vitro. , The 11th International Conference on Healthy Aging. 2016, 61. |
| Researcher : IEONG IL |
| List of Research Outputs |
| IEONG I.L., GHOSH S. and Zhou Z., Post-translational modifications of KAP1 and its biological relevance, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Researcher : JIANG Q |
| List of Research Outputs |
| JIANG Q., Shum D.K.Y. and Chan Y.S., Antidepressant re-opens the plasticity of vestibular-mediated navigation in the adult, Abstracts of 11th Int’l Symp. on Healthy Aging: Science and Aging – An Era of Discovery. 2016, 48. |
| JIANG Q., Shum D.K.Y. and Chan Y.S., Antidepressant reinstates the plasticity in the adult vestibular nucleus, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| JIANG Q., Ma C.W., Chen C.W., Shum D.K.Y. and Chan Y.S., Fluoxetine induces rejuvenation of plasticity in the vestibular system of adult rats IP106. [Kobe, Japan. July 28-31, 2015], Proc. 38th Annual Meeting of Japan Neuroscience Society. 2015. |
| JIANG Q., Ma C.W., CHEN W., Shum D.K.Y. and Chan Y.S., Fluoxetine induces restoration of plasticity in the adult vestibular system [25th Meeting of International Society for Neurochemistry Cairns, Australia. Aug. 23-27, 2015], Journal of Neurochemistry. 2015. |
| JIANG Q. and Chan Y.S., Sun Chieh Yeh Young Investigator Award to Qiu-Fen Jiang (Oral Category), 11th International Symposium on Healthy Aging [HK March 2016]. 2016. |
| LAM T.F., JIANG Q. and Chan Y.S., Developmental Roles of Orexin in the Central Vestibular System on Acquisition of Motor Coordination and Spatial Recognition, 11th International Symposium on Healthy Aging. 2016. |
| Lam U.T.F., JIANG Q. and Chan Y.S., Developmental roles of orexin in the central vestibular system on acquisition of motor coordination and spatial recognition [HK. March 12-13, 2016], Abstracts of 11th Int’l Symp. on Healthy Aging: Science and Aging – An Era of Discovery. 2016, 60. |
| Researcher : JIANG Y |
| List of Research Outputs |
| JIANG Y., Ma C.W., Wang J.J. and Chan Y.S., Orexin modulates inhibitory synaptic transmission of vestibular nuclear neurons in rats [HK. May 18, 2016], Proc. Neuroscience Symposium 2016 & Scientific Conference of The Hong Kong Society of Neurosciences. 2016, 37. |
| JIANG Y., Ma C.W., Wang J.J. and Chan Y.S., Orexin modulates inhibitory synaptic transmission of vestibular nuclear neurons in rats, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| Researcher : JIANG Z |
| List of Research Outputs |
| Chiu K., JIANG Z., Dang Y., Yu S. and Lai J.S.M., Neuroprotective Effects of Papaverine on Retinal Ganglion Cells in Optic Nerve Transection Model, 6th Global Ophthalmologists Annual Meeting. 2016. |
| Researcher : Jia LJ |
| List of Research Outputs |
| Jia L.J., Tsang C.M., Yip Y.L., Law W., ZHANG J., Deng W. and Tsao G.S.W., Establishment and characterization of immortalized nasopharyngeal epithelial cells with stable infection of Epstein-Barr virus, Gordon Research Conference - Nasopharyngeal Carcinoma. 2016. |
| ZHANG J., Jia L.J., LIN W., Yip Y.L., Tsang C.M., Zhou Y., Zhu D., Deng W. and Tsao G.S.W., Significance of Epstein-Barr virus encoded Latent Membrane Protein 1-Induced mTOR Signaling in Nasopharyngeal Cells, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Researcher : Jin D |
| Project Title: | Mitotic checkpoint and genomic stability in ovarian cancer |
| Investigator(s): | Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | National Institutes of Health, US Department of Health and Human Services - General Award |
| Start Date: | 09/2002 |
| Project Title: | Outstanding Researcher Award 2007-2008 |
| Investigator(s): | Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | Outstanding Researcher Award |
| Start Date: | 10/2008 |
| Project Title: | 4th Intracellular Proteolysis Meeting on Ubiquitin-proteasome System, Dynamics and Targeting REV7-mediated polyubiquitination and degradation of human REV1 |
| Investigator(s): | Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2009 |
| Project Title: | Knockdown of miR-BART5 in Epstein-Barr Virus-infected Cells by RNA Decoys Delivered through Novel Adenoviral Vectors: a New Paradigm for Cancer Therapy |
| Investigator(s): | Jin D, Kok KH, Lei T |
| Department: | Biochemistry |
| Source(s) of Funding: | Innovation and Technology Support Programme (Tier 3) |
| Start Date: | 01/2010 |
| Project Title: | Knockdown of miR-BART5 in Epstein-Barr Virus-infected Cells by RNA Decoys Delivered through Novel Adenoviral Vectors: a New Paradigm for Cancer Therapy |
| Investigator(s): | Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 01/2010 |
| Project Title: | Knockdown of miR-BART5 in Epstein-Barr Virus-infected Cells by RNA Decoys Delivered through Novel Adenoviral Vectors: a New Paradigm for Cancer Therapy |
| Investigator(s): | Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 01/2010 |
| Project Title: | Mapping of peptide sequence in swine-origin H1N1 influenza virus hemagglutinin associated with the induction of anti-ganglioside antibodies implicated in Guillain-Barre syndrome: a pilot study |
| Investigator(s): | Jin D, Zheng B |
| Department: | Biochemistry |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 01/2011 |
| Project Title: | Roles of LKB1 tumor suppressor in human T-cell leukemia virus type I transcription and leukemogenesis |
| Investigator(s): | Jin D, Tang HMV |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2012 |
| Completion Date: | 08/2015 |
| Project Title: | Molecular dissection of NSs virulence factor in severe fever with thrombocytopenia syndrome virus (SFTSV), a novel bunyavirus identified in China |
| Investigator(s): | Jin D, Kok KH |
| Department: | Biochemistry |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2013 |
| Project Title: | Roles of Epstein-Barr virus-encoded miR-BART microRNAs in viral persistence and transformation of epithelial cells |
| Investigator(s): | Jin D, Huang J, Tang HMV |
| Department: | Biochemistry |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2013 |
| Completion Date: | 06/2016 |
| Project Title: | Roles of CRTC coactivators in hepatitis B virus X protein-mediated activation of CREB-dependent transcription |
| Investigator(s): | Jin D, Zheng B, Zhou J, Tang HMV |
| Department: | Biochemistry |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2013 |
| Completion Date: | 10/2016 |
| Project Title: | Roles of SIRT1 deacetylase in human T-cell leukemia virus type I transcription and leukemogenesis |
| Investigator(s): | Jin D, Ching YP, Tu W |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Completion Date: | 12/2015 |
| Project Title: | Regulatory roles of SIRT1 deacetylase in hepatitis B virus transcription |
| Investigator(s): | Jin D, Zhou J, Tang HMV |
| Department: | Biochemistry |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2014 |
| Project Title: | Mechanism of inflammasome activation by SARS coronavirus 3a protein |
| Investigator(s): | Jin D, Zheng B, Tang HMV |
| Department: | Biochemistry |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2014 |
| Project Title: | Characterization of a novel cGAMP-hydrolyzing phosphodiesterase encoded by Middle East respiratory syndrome coronavirus |
| Investigator(s): | Jin D, Tse H |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | Outstanding Research Student Supervisor Award 2013-14 |
| Investigator(s): | Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | Outstanding Research Student Supervisor Award |
| Start Date: | 12/2014 |
| Project Title: | Identification and characterization of human cyclic dinucleotide phosphodiesterases that hydrolyze cGAMP second messenger |
| Investigator(s): | Jin D, Tse H |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Novel regulatory mechanisms in RIG-I-dependent innate antiviral response |
| Investigator(s): | Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | Croucher Senior Research Fellowships in Natural Sciences, Technology and Medicine |
| Start Date: | 01/2015 |
| Completion Date: | 01/2016 |
| Project Title: | Characterization of a novel β-TrCP-dependent pathway for ubiquitination and degradation of liver-enriched transcription factor CREB-H |
| Investigator(s): | Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2015 |
| Project Title: | Suppression of innate interferon production by Middle East respiratory syndrome coronavirus M protein |
| Investigator(s): | Jin D, Yeung ML |
| Department: | Biochemistry |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2015 |
| Project Title: | American Society for Virology 34th Annual Meeting; Activation of NLRP3 inflammasomes by severe acute respiratory syndrome coronavirus 3a protein |
| Investigator(s): | Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2015 |
| Completion Date: | 07/2015 |
| Project Title: | Identification and characterization of a novel transcript isoform of STING that negatively regulates innate antiviral response |
| Investigator(s): | Jin D, Yang W, Deng J |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2016 |
| Project Title: | Suppression of hepatitis B virus transcription by LKB1 and salt-inducible kinases |
| Investigator(s): | Jin D, Deng J, Kong KY |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2016 |
| Project Title: | Molecular Mechanism of PACT-dependent Innate Antiviral Response |
| Investigator(s): | Jin D, Chan CP, Sham MH, Yeung ML, Yuen KY, Zheng B, Zhou J |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 06/2016 |
| List of Research Outputs |
| CHAUDHARY V., ZHANG S., Yuen K.S., LI D., Kok K.H., LIANG M. and Jin D., Opposite effect of severe fever-with-thrombocytopenia syndrome virus NSs protein on type I and type II interferon signaling, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| CHAUDHARY V., Zhang S., Yuen K.S., Li C., Lui P.Y., FUNG S.Y., WANG P., Chan C.P., Li D., Kok K.H., Liang M. and Jin D., Suppression of type I and type III interferon signalling by NSs protein of severe fever-with-thrombocytopenia syndrome virus through inhibition of STAT1 phosphorylation and activation, Journal of General Virology. 2015. |
| CHENG Y., GAO W., Tang H.M.V., Deng J., Wong C.M., Chan C.P. and Jin D., β-TrCP-mediated ubiquitination and degradation of liver-enriched transcription factor CREB-H, Scientific Reports. 2016, 6. |
| CHENG Y., GAO W., Tang H.M.V., Deng J., Chan C.P. and Jin D., β-TrCP-mediated ubiquitination and degradation of liver-enriched transcription, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Chan C.P., YUEN C.K., FUNG S.Y., KEW C., Yuen K.Y., Kok K.H. and Jin D., Antagonising roles between PACT and influenza A virus polymerase subunits in viral replication and innate immune response, American Association for Immunologists Annual Meeting - Immunology 2016. |
| Chan C.P., YUEN C.K., FUNG S.Y., KEW C., Zheng B., Yuen K.Y., Kok K.H. and Jin D., Influenza A virus NS1 protein targets double stranded RNA-binding protein PACT to suppress innate antiviral response , 10th Asia-Pacific Congress of Medical Virology 2015. |
| GAO W., Tang H.M.V., CHENG Y., Deng J., Chan C.P. and Jin D., Ubiquitination and degradation of CRTC1 transcriptional coactivator triggered by salt-inducible kinase 1-dependent phosphorylation, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| HO T.H., KEW C., LUI P.Y., Chan C.P., Satoh T., Akira S., Jin D. and Kok K.H., PACT- and RIG-I-Dependent Activation of Type I Interferon Production by a Defective Interfering RNA Derived from Measles Virus Vaccine, Journal of Virology. 2016, 90: 1557-1568. |
| Jin D., Siu K.L., Yuen K.S., Yeung M.L., Kok K.H. and Yuen K.Y., Activation of NLRP3 inflammasomes by severe acute respiratory syndrome coronavirus 3a protein, The American Society for Virology 34th Annual Meeting. 2015. |
| Jin D., Editorial Board Member, Microbes and Emerging Infections. Nature Publishing Group, 2015. |
| Jin D., Tang H.M.V., GAO W., Chan C.P., Iha H. and Yuen K.S., Suppression of HTLV-1 transcription by SIRT1 deacetylase, Retrovirology. 2015, 12: P53. |
| Lui P.Y., WONG L.Y.R., Fung C.L., Siu K.L., Yeung M.L., Yuen K.S., Chan C.P., Woo P.C.Y., Yuen K.Y. and Jin D., Middle East respiratory syndrome coronavirus M protein suppresses type I interferon expression through the inhibition of TBK1-dependent phosphorylation of IRF3, Emerging Microbes & Infections. 2016, 5: e39. |
| Plani-Lam J.H., Chow T.C., Fan Y., Garcia-Bloj B., Cheng L., Jin D., Hancock W., Fanayan S., Ingley E. and Song Y., High expression of PTPN21 in B-cell non-Hodgkin's gastric lymphoma, a positive mediator of STAT5 activity, Blood Cancer J.. 2016, 15;6:e388. |
| Siu C.W.K., Lam C.W., Gao W., Tang H.M.V., Jin D. and Mak C.M., Unmasking a novel disease gene NEO1 associated with autism spectrum disorders by a hemizygous deletion on chromosome 15 and a functional polymorphism, Behavioural Brain Research. 2016, 300: 135-142. |
| Tang H.M.V., GAO W., Chan C.P., CHENG Y., Deng J., Yuen K.S., Iha H. and Jin D., SIRT1 Suppresses Human T-Cell Leukemia Virus Type 1 Transcription, Journal of Virology. 2015, 89: 8623-8631. |
| Wong L.W.M., YUEN C.K., Chan C.P., Jin D. and Kok K.H., Mutual Antagonism Between Pact And Influenza A Virus Polymerase Subunits Regulates Viral Replication And Interferon Production., American Society For Virology. 2016. |
| YUEN C.K., Chan C.P., FUNG S.Y., WANG P., Wong L.W.M., Tang H.M.V., Yuen K.S., Chan C.P., Jin D. and Kok K.H., Suppression of Type I Interferon Production by Human T-Cell Leukemia Virus Type 1 Oncoprotein Tax through Inhibition of IRF3 Phosphorylation, Journal of Virology. 2016, 90: 3902-3912. |
| Researcher : Jin J |
| List of Research Outputs |
| YAO H., Jin J., Wong K.Y.G. and Chan C.W.Y., Oxidative Stress Induces Autophagy in Human Embryonic Stem Cell-derived Cardiomyocytes (hESC-CMs), 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Researcher : KHONG ML |
| List of Research Outputs |
| KHONG M.L., Li L., LU B., Watt R.M. and Tanner J.A., Determining proteins that specifically bind to polyphosphate in osteoblasts, Inorganic polyphosphate (polyP) physiology. Biochemical Society Hot Topic Event, London, UK. 2015. |
| KHONG M.L. and Tanner J.A., Elucidating the Functional Implications of Polyphosphate-Protein Interactions, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| KHONG M.L., Li L. and Tanner J.A., Elucidating the Functional Implications of Polyphosphate-protein Interactions, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, Chinese University of Hong Kong, Hong Kong. 2016. |
| Li L., KHONG M.L., Lu B., Buchet R., Watt R.M. and Tanner J.A., Long-chain inorganic polyphosphate is highly enriched in osteoblastic matrix vesicles., 40th FEBS Congress 2015 “The Biochemical Basis of Life”, Berlin, Germany (2015).. 2015. |
| Li L., KHONG M.L., Mebarek R., Buchet R. and Tanner J.A., Long-chain polyphosphate is enriched in mineralized osteoblasts and matrix vesicles, Inorganic polyphosphate (polyP) physiology, Biochemistry Society Hot Topic Event, London, UK. 2015. |
| Researcher : KINGHORN AB |
| List of Research Outputs |
| DIRKZWAGER R.M., FRASER L.A., LIANG S., Cheung Y.W., KINGHORN A.B., Richards J.S. and Tanner J.A., DNA aptamers as antibody surrogates for molecular recognition in rapid diagnostic tests for malaria, Molecular Approaches to Malaria, Lorne, Australia. 2016. |
| DIRKZWAGER R.M., Cheung Y.W., KINGHORN A.B., FRASER L.A., LIANG S., TANG S.L.M., Kotaka M., Richards J.S. and Tanner J.A., DNA aptamers for malaria diagnosis – from crystal structure to clinical application., 40th FEBS Congress 2015 “The Biochemical Basis of Life”, Berlin, Germany (2015). 2015. |
| FRASER L.A., DIRKZWAGER R.M., LIANG S., Cheung Y.W., KINGHORN A.B., Lim B. and Tanner J.A., 3D printing aptamer based rapid diagnostic tests for the point of care diagnosis of malaria, Malaria in Melbourne (MiM), Monash University, Melbourne, Australia. 2015. |
| FRASER L.A., KINGHORN A.B., TANG S.L.M., Cheung Y.W., Lim B., LIANG S., DIRKZWAGER R.M. and Tanner J.A., Oligonucleotide Functionalised Microbeads: Indispensable Tools for High-Throughput Aptamer Selection, Molecules. 2015, 20: 21298-21312. |
| Godonoga M., Lin T.Y., Oshima A., Sumitomo K., TANG S.L.M., Cheung Y.W., KINGHORN A.B., DIRKZWAGER R.M., Zhou C., Kuzuya A., Tanner J.A. and Heddle J.G., A DNA aptamer recognising a malaria protein biomarker can function as part of a DNA origami assembly, Scientific Reports. 2016, 6: 21266. |
| KINGHORN A.B., In Silico and In Vitro Approaches to Aptamer Enrichment, Selection and Evolution, PhD Thesis, The University of Hong Kong. 2016. |
| SHIU C.C., Cheung Y.W., DIRKZWAGER R.M., LIANG S., KINGHORN A.B., FRASER L.A., TANG S.L.M. and Tanner J.A., Aptamer-Directed DNA Tweezers, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, Chinese University of Hong Kong, Hong Kong. 2016. |
| SHIU C.C., Cheung Y.W., DIRKZWAGER R.M., LIANG S., KINGHORN A.B., FRASER L.A., TANG S.L.M. and Tanner J.A., Aptamer-mediated macromolecular recognition in facilitating DNA tweezer machinery, Aptamers in Bordeaux, Bordeaux, France. 2016. |
| SHIU C.C., Cheung Y.W., DIRKZWAGER R.M., LIANG S., KINGHORN A.B., FRASER L.A., TANG S.L.M. and Tanner J.A., Best Poster Prize: Aptamer-Directed DNA Tweezers, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, Chinese University of Hong Kong, Hong Kong 2016. 2016. |
| Schmidt C., Schroder C., Tanner J.A., KINGHORN A.B., Schierack P. and Rodiger S.A., A multiplex high-throughput screening platform for investigation of buffer-binding conditions for aptamers., Potsdam Days on Bioanalysis, Berlin, Germany. 2015. |
| TANG S.L.M., Godonoga M., DIRKZWAGER R.M., KINGHORN A.B., Heddle J.G. and Tanner J.A., Aptamer-functionalized DNA origami: an emerging tool for malaria diagnosis, Hong Kong Inter-University Postgraduate Symposium on Life Science. 2016. |
| TANG S.L.M., Godonoga M., KINGHORN A.B., Cheung Y.W., Heddle J. and Tanner J.A., Aptamer-gated DNA origami nanobox for malaria detection, Aptamers in Bordeaux, Bordeaux, France. 2016. |
| TANG S.L.M., Godonoga M., KINGHORN A.B., Cheung Y.W., Heddle J. and Tanner J.A., Construction and characterization of a three-dimensional nanoscale DNA origami box functionalized by a malaria aptamer, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, Chinese University of Hong Kong, Hong Kong. 2016. |
| TANG S.L.M., Godonoga M., KINGHORN A.B., Cheung Y.W., Heddle J. and Tanner J.A., Functionalising DNA nanostructures with aptamers for molecular recognition and dynamic response, Oligo 2016 Oxford: Antisense & Therapeutic Nucleic Acids, Oxford University, United Kingdom. 2016. |
| Researcher : KWAN PY |
| List of Research Outputs |
| KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Role of perineuronal chondroitin sulfates and semaphorin 3A in the maturation of the vestibular circuitry [HK. March 12-13, 2016], Abstracts of 11th Int’l Symp. on Healthy Aging: Science and Aging – An Era of Discovery. 2016, 70. |
| KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Roles of perineuronal chondroitin sulfates and semaphorin 3A in the maturation of the vestibular circuitry, Abstracts of 11th Int’l Symp. on Healthy Aging: 70. 2016. |
| KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., The Regulatory Roles of Semaphorin 3A and Chondroitin Sulfates on Perineuronal Nets in the Developing Vestibular Circuitry, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., The Roles of Semaphorin 3A and Chondroitin Sulfates on Perineuronal Nets in Regulating the Development of Vestibular Circuitry, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Researcher : Keung WWY |
| Project Title: | Driving maturation of human embryonic stem cell-derived cardiomyocytes through metabolic conditioning in 2D and 3D environment |
| Investigator(s): | Keung WWY |
| Department: | Physiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 09/2014 |
| Completion Date: | 09/2016 |
| Project Title: | Modeling cardiomyopathy with 3D cardiac tissue constructs of patient specific induced-pluripotent stem cells |
| Investigator(s): | Keung WWY |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2016 |
| List of Research Outputs |
| Chan H.Y.S., Keung W.W.Y., Li R.A., Miller A.L. and Webb S.E., Morphometric Analysis of Human Embryonic Stem Cell-Derived Ventricular Cardiomyocytes: Determining the Maturation State of a Population by Quantifying Parameters in Individual Cells, Stem Cells International. 2015, 2015: 1-13. |
| WONG N.C.S., Keung W.W.Y., Chow M.Z.Y., WONG O.T. and Li R.A., Maturation of Human Pluripotent Stem Cell Derived Cardiomyocyte, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| WONG N.C.S., Chow M.Z.Y., Keung W.W.Y. and Li R.A., Maturation of hPSC-CMs in Bioenergetics driven by Oleic Acid and PPARα agonist, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Researcher : Kong MCW |
| List of Research Outputs |
| Wang Y., Li Z.C., Zhang P.I., Poon N.Y.E., Kong M.C.W., Boheler K.R., Huang Y. and Yao X., Nitric Oxide-cGMP-PKG Pathway Acts on Orai1 to Inhibit the Hypertrophy of Human Embryonic Stem Cell-Derived Cardiomyocytes, STEM CELLS. 2015, n/a-n/a. |
| Researcher : Kudelko MA |
| List of Research Outputs |
| Kudelko M.A., Sharma R., Cheah K.S.E. and Chan D., Comparison of proteomic datasets from hypertrophic chondrocytes in response to ER stress, Data Brief. 2016, 7: 449-51. |
| Researcher : Kwok CTD |
| List of Research Outputs |
| Kwok C.T.D., LEUNG M.H., Qin J., QIN Y., Wang J.J., Lee C.Y.L. and Yao K.M., The Forkhead box transcription factor FOXM1 is required for the maintenance of cell proliferation and protection against oxidative stress in human embryonic stem cells, Stem Cell Research. 2016. |
| Researcher : Kwok LF |
| List of Research Outputs |
| Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Combination of uniaxial chitosan nanofibers and immobilized chondroitinase ABC improves axonal regrowth in vitro, 11st International Symposium on Healthy Aging: Science and Aging: An Era of Discovery. 2016. |
| Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Combination of uniaxial chitosan nanofibers and immobilized chondroitinase ABS improves axonal regrowth in vitro [HK. March 12-13, 2016], Abstracts of 11th Int’l Symp. on Healthy Aging: Science and Aging – An Era of Discovery. 2016, 60. |
| Researcher : LAM CF |
| List of Research Outputs |
| LAM C.F., The Role of Reactive Oxygen Species in Differentiation of Acute Myeloid Leukemia, PhD Thesis, The University of Hong Kong. 2016. |
| Researcher : LAM CS |
| List of Research Outputs |
| Kang J.J., Liang W.H., LAM C.S., Huang X.F., Yang S.J., MT W.O.N.G.-.R.I.L.E.Y., Fung M.L. and Liu Y.Y., Catecholaminergic neurons in synaptic connections with pre-Botzinger complex neurons in the rostral ventrolateral medulla in normoxic and daily acute intermittent hypoxic rats., Experimental Neurology In Press. 2016. |
| LAM C.S., Lee M.K.Y., Mak J.C.W., Fung A.C.H., Tipoe G.L. and Fung M.L., Chronic intermittent hypoxia exacerbates depressive-like behaviors in high fat diet-fed mice. The 19th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, Journal of the Hong Kong College of Cardiology. 2015, 23(2): 97, CP5. |
| LAM C.S., LI J., LIU Y.Y., Tipoe G.L. and Fung M.L., Maladaptive up-regulation of brain monoamine oxidase-A contributes to depressive-like behavior in a rat model of obstructive sleep apnea, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| LAM C.S., LI J., Tipoe G.L. and Fung M.L., Maladaptive up-regulation of brain monoamine oxidase-A contributes to depressive-like behaviors in a rat model of obstructive sleep apnea, 20th Research Postgraduate Symposium, HKU. 2015, P3.3. |
| LAM C.S., Lee M.K.Y., Mak J.C.W., Ip M.S.M., Fung A.C.H., Tipoe G.L. and Fung M.L., Mechanistic roles of monoamine oxidase A in the exacerbative effect of chronic intermittent hypoxia on the depressive-like behavior in the mice model of diet-induced obesity. The Eleventh Eleventh International Symposium on Healthy Aging – Science and Aging, An Era of Discovery, OP3. 2016. |
| LAM C.S., Tipoe G.L., Wong K.C., Youdim M.B.H. and Fung M.L., Multifunctional drug M30 mitigates neurodegeneration and depressive-like behaviors induced by corticosterone in rats. Hong Kong Inter-University Postgraduate Symposium, Biochemical Sciences. 2016. |
| LAM C.S., Tipoe G.L., Wong K.C., Youdim M.B.H. and Fung M.L., Multifunctional drug M30 mitigates neurodegeneration and depressive-like behaviors induced by corticosterone in rats, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| LAM C.S., Tipoe G.L., So K.F. and Fung M.L., Polysaccharides antagonized rat hippocampal-dependent spatial memory deficits induced by chronic intermittent hypoxia. First Exchange Camp for Biomedical Research Students in Guangdong, Hong Kong and Macau, Lycium barbarum. 2015. |
| LI J., LAM C.S., Tipoe G.L. and Fung M.L., Increased MAO-A Expression Mediated by Norepinephrine Plays a Role in Intermittent Hypoxia-induced Oxidative Stress and Cell Death in SH-SY5Y Cells, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| LI J., LAM C.S., Tipoe G.L. and Fung M.L., Increased MAO-A expression mediated by norepinephrine plays a role in intermittent hypoxia-induced oxidative stress and cell death in SH-SY5Y cells, 20th Research Postgraduate Symposium, HKU. 2015, P3.06. |
| LI J., LAM C.S., Tipoe G.L. and Fung M.L., Norepinephrine increases the monoamine oxidase-A and oxidative stress in SH-SY5Y cells. The 19th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, Journal of the Hong Kong College of Cardiology. 2015, 23(2): 95, CP1. |
| LI J., LAM C.S., Tipoe G.L. and Fung M.L., Upregulated biosynthesis of Norepinephrine and MAOA expression mediates the oxidative stress and cell death in SH-SY5Y cells, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| LI J., LAM C.S., Tipoe G.L. and Fung M.L., Upregulated biosynthesis of norepinephrine and MAOA expression mediates the oxidative stress and cell death in SH-SY5Y cells. The Eleventh International Symposium on Healthy Aging, Science and Aging: An Era of Discovery. 2016, P47. |
| Researcher : LAM TF |
| List of Research Outputs |
| LAM T.F., JIANG Q. and Chan Y.S., Developmental Roles of Orexin in the Central Vestibular System on Acquisition of Motor Coordination and Spatial Recognition, 11th International Symposium on Healthy Aging. 2016. |
| LAM T.F. and Chan Y.S., Modulatory Effects of Orexin on the Functional Maturation of Central Vestibular System in Motor Coordination and Spatial Recognition, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| LAM T.F. and Chan Y.S., Role of Orexin in Functional Maturation of Central Vestibular System in Motor Coordination and Spatial Recognition, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Researcher : LAU CC |
| List of Research Outputs |
| LAU C.C. and Ma S.K.Y., Characterization of a novel oncogene follistatin-like 1 (FSTL1) in esophageal squamous cell carcinoma (ESCC), Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| LAU C.C. and Ma S.K.Y., Identification and Characterization of a Novel Oncogene Follistatin-Like 1 in Esophageal Squamous Cell Carcinoma, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Researcher : LEE SK |
| List of Research Outputs |
| LEE S.K., TONG C.K.B., CHENG W.H., HUNG C.H. and Cheung K.H., Characterization of Two-Pore Channel 2 by Nuclear Membrane Electrophysiology, Scientific Reports. 2016, 6: 20282. |
| LEE S.K., TONG C.K.B. and Cheung K.H., Regulation of Ryanodine Receptor Type 2 Single Channel Activities by Cyclic-ADP-ribose and Calcium, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Researcher : LI H |
| List of Research Outputs |
| Lai H.M., LIU K.L., Ng W.L., DeFelice J., Lee W.S., LI H., LI W., NG H.M., Chang R.C.C., Lin B., Wu W. and Gentleman S.M., Rationalisation and validation of an acrylamide-free procedure in three-dimensional histological imaging, PloS One. 2016, 11: e0158628. |
| Researcher : LI J |
| List of Research Outputs |
| LAM C.S., LI J., LIU Y.Y., Tipoe G.L. and Fung M.L., Maladaptive up-regulation of brain monoamine oxidase-A contributes to depressive-like behavior in a rat model of obstructive sleep apnea, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| LAM C.S., LI J., Tipoe G.L. and Fung M.L., Maladaptive up-regulation of brain monoamine oxidase-A contributes to depressive-like behaviors in a rat model of obstructive sleep apnea, 20th Research Postgraduate Symposium, HKU. 2015, P3.3. |
| LI J., LAM C.S., Tipoe G.L. and Fung M.L., Increased MAO-A Expression Mediated by Norepinephrine Plays a Role in Intermittent Hypoxia-induced Oxidative Stress and Cell Death in SH-SY5Y Cells, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| LI J., LAM C.S., Tipoe G.L. and Fung M.L., Increased MAO-A expression mediated by norepinephrine plays a role in intermittent hypoxia-induced oxidative stress and cell death in SH-SY5Y cells, 20th Research Postgraduate Symposium, HKU. 2015, P3.06. |
| LI J., Song Y., Sham P.C. and Li M., KGGSeq: a rapid and robust framework for large-scale whole genome sequencing downstream analysis with integrative functions, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| LI J., LAM C.S., Tipoe G.L. and Fung M.L., Norepinephrine increases the monoamine oxidase-A and oxidative stress in SH-SY5Y cells. The 19th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, Journal of the Hong Kong College of Cardiology. 2015, 23(2): 95, CP1. |
| LI J., LAM C.S., Tipoe G.L. and Fung M.L., Upregulated biosynthesis of Norepinephrine and MAOA expression mediates the oxidative stress and cell death in SH-SY5Y cells, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| LI J., LAM C.S., Tipoe G.L. and Fung M.L., Upregulated biosynthesis of norepinephrine and MAOA expression mediates the oxidative stress and cell death in SH-SY5Y cells. The Eleventh International Symposium on Healthy Aging, Science and Aging: An Era of Discovery. 2016, P47. |
| Researcher : LI J |
| List of Research Outputs |
| LAM C.S., LI J., LIU Y.Y., Tipoe G.L. and Fung M.L., Maladaptive up-regulation of brain monoamine oxidase-A contributes to depressive-like behavior in a rat model of obstructive sleep apnea, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| LAM C.S., LI J., Tipoe G.L. and Fung M.L., Maladaptive up-regulation of brain monoamine oxidase-A contributes to depressive-like behaviors in a rat model of obstructive sleep apnea, 20th Research Postgraduate Symposium, HKU. 2015, P3.3. |
| LI J., LAM C.S., Tipoe G.L. and Fung M.L., Increased MAO-A Expression Mediated by Norepinephrine Plays a Role in Intermittent Hypoxia-induced Oxidative Stress and Cell Death in SH-SY5Y Cells, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| LI J., LAM C.S., Tipoe G.L. and Fung M.L., Increased MAO-A expression mediated by norepinephrine plays a role in intermittent hypoxia-induced oxidative stress and cell death in SH-SY5Y cells, 20th Research Postgraduate Symposium, HKU. 2015, P3.06. |
| LI J., Song Y., Sham P.C. and Li M., KGGSeq: a rapid and robust framework for large-scale whole genome sequencing downstream analysis with integrative functions, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| LI J., LAM C.S., Tipoe G.L. and Fung M.L., Norepinephrine increases the monoamine oxidase-A and oxidative stress in SH-SY5Y cells. The 19th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, Journal of the Hong Kong College of Cardiology. 2015, 23(2): 95, CP1. |
| LI J., LAM C.S., Tipoe G.L. and Fung M.L., Upregulated biosynthesis of Norepinephrine and MAOA expression mediates the oxidative stress and cell death in SH-SY5Y cells, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| LI J., LAM C.S., Tipoe G.L. and Fung M.L., Upregulated biosynthesis of norepinephrine and MAOA expression mediates the oxidative stress and cell death in SH-SY5Y cells. The Eleventh International Symposium on Healthy Aging, Science and Aging: An Era of Discovery. 2016, P47. |
| Researcher : LI T |
| List of Research Outputs |
| LI T., Lian F., Xie S., DU Y. and Qian C., Molecular insights into histone H3 ubiquitination dependent maintenance DNA methylation, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| LI T., Structural and mechanistic insights into UHRF1-coordinated maintenance DNA methylation by DNMT1, MPhil Thesis, The University of Hong Kong. 2016. |
| LI T., Ren C., Huang L., Lin B., Pu M., Pickard G.E. and So K.F., The Dorsal Raphe Nucleus Receives Afferents From Alpha-Like Retinal Ganglion Cells and Intrinsically Photosensitive Retinal Ganglion Cells in the Rat, Investigative Opthalmology & Visual Science. 2015, 56: 8373. |
| Researcher : LI W |
| List of Research Outputs |
| Lai H.M., LIU K.L., Ng W.L., DeFelice J., Lee W.S., LI H., LI W., NG H.M., Chang R.C.C., Lin B., Wu W. and Gentleman S.M., Rationalisation and validation of an acrylamide-free procedure in three-dimensional histological imaging, PloS One. 2016, 11: e0158628. |
| Researcher : LI Z |
| List of Research Outputs |
| LI Z., Lam Y.L., Cham C.W., Ma C.W., Chan Y.S. and Shum D.K.Y., Axonal trafficking and localized trafficking of heparanase 1 [HK. March 12-13, 2016], Abstracts of 11th Int’l Symp. on Healthy Aging: Science and Aging – An Era of Discovery. 2016, 60. |
| LI Z., LAM Y.L., CHAM W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Axonal trafficking and localized trafficking of heparanase 1, Abstracts of 11th Int’l Symp. on Healthy Aging: 60. 2016. |
| LI Z., Ma C.W., Chan Y.S. and Shum D.K.Y., Axonal trafficking of heparanase 1, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| LI Z., SIT H.M. and Sham M.H., Ephs and ephrins in the Enteric Nervous System Development, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Researcher : LI Z |
| List of Research Outputs |
| LI Z., Lam Y.L., Cham C.W., Ma C.W., Chan Y.S. and Shum D.K.Y., Axonal trafficking and localized trafficking of heparanase 1 [HK. March 12-13, 2016], Abstracts of 11th Int’l Symp. on Healthy Aging: Science and Aging – An Era of Discovery. 2016, 60. |
| LI Z., LAM Y.L., CHAM W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Axonal trafficking and localized trafficking of heparanase 1, Abstracts of 11th Int’l Symp. on Healthy Aging: 60. 2016. |
| LI Z., Ma C.W., Chan Y.S. and Shum D.K.Y., Axonal trafficking of heparanase 1, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| LI Z., SIT H.M. and Sham M.H., Ephs and ephrins in the Enteric Nervous System Development, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Researcher : LIANG S |
| List of Research Outputs |
| DIRKZWAGER R.M., FRASER L.A., LIANG S., Cheung Y.W., KINGHORN A.B., Richards J.S. and Tanner J.A., DNA aptamers as antibody surrogates for molecular recognition in rapid diagnostic tests for malaria, Molecular Approaches to Malaria, Lorne, Australia. 2016. |
| DIRKZWAGER R.M., Cheung Y.W., KINGHORN A.B., FRASER L.A., LIANG S., TANG S.L.M., Kotaka M., Richards J.S. and Tanner J.A., DNA aptamers for malaria diagnosis – from crystal structure to clinical application., 40th FEBS Congress 2015 “The Biochemical Basis of Life”, Berlin, Germany (2015). 2015. |
| DIRKZWAGER R.M., LIANG S. and Tanner J.A., Development of Aptamer-Based Point-of-Care Diagnostic Devices for Malaria Using Three-Dimensional Printing Rapid Prototyping, ACS Sensors. 2016, 1: 420-426. |
| FRASER L.A., DIRKZWAGER R.M., LIANG S., Cheung Y.W., KINGHORN A.B., Lim B. and Tanner J.A., 3D printing aptamer based rapid diagnostic tests for the point of care diagnosis of malaria, Malaria in Melbourne (MiM), Monash University, Melbourne, Australia. 2015. |
| FRASER L.A., KINGHORN A.B., TANG S.L.M., Cheung Y.W., Lim B., LIANG S., DIRKZWAGER R.M. and Tanner J.A., Oligonucleotide Functionalised Microbeads: Indispensable Tools for High-Throughput Aptamer Selection, Molecules. 2015, 20: 21298-21312. |
| LIANG S., Dhillo W., Cass A.E.G. and Tanner J.A., Development of aptamer-based electrochemical sensing system for monitoring luteinizing hormone pulsatility, Aptamers in Bordeaux, Bordeaux, France. 2016. |
| LIANG S., DIRKZWAGER R.M. and Tanner J.A., Rapid prototyping aptamer-enabled malaria diagnostics using three-dimensional printing, Aptamers 2016, 3rd Oxford Symposium on Aptamers, Oxford University, United Kingdom. 2016. |
| SHIU C.C., Cheung Y.W., DIRKZWAGER R.M., LIANG S., KINGHORN A.B., FRASER L.A., TANG S.L.M. and Tanner J.A., Aptamer-Directed DNA Tweezers, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, Chinese University of Hong Kong, Hong Kong. 2016. |
| SHIU C.C., Cheung Y.W., DIRKZWAGER R.M., LIANG S., KINGHORN A.B., FRASER L.A., TANG S.L.M. and Tanner J.A., Aptamer-mediated macromolecular recognition in facilitating DNA tweezer machinery, Aptamers in Bordeaux, Bordeaux, France. 2016. |
| SHIU C.C., Cheung Y.W., DIRKZWAGER R.M., LIANG S., KINGHORN A.B., FRASER L.A., TANG S.L.M. and Tanner J.A., Best Poster Prize: Aptamer-Directed DNA Tweezers, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, Chinese University of Hong Kong, Hong Kong 2016. 2016. |
| Researcher : LIANG Y |
| List of Research Outputs |
| LIANG Y., Wong Y.M.E., LIU Y., Krauss R.S., Xu P.X., Hui C.C. and Sham M.H., The role of Hedgehog receptor Cdo in controlling cochlear hair cell and pillar cell formation, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| LIANG Y., Wong Y.M.E., LIU Y., Hui C.C. and Sham M.H., The role of Hedgehog receptor Cdo in controlling cochlear hair cell and pillar cell formation, Hong Kong Inter-University Postgraduate symposium in Biochemical Sciences 2016. |
| Researcher : LIN L |
| List of Research Outputs |
| LIN L., LO H.Y.L., Lyu Q. and Lai K.O., A potential role of NMDA receptor-dependent expression of Striatin-4 (STRN4) in dendritic spine maturation, Gordon Research Conference "Cell Biology of the Neuron". 2016. |
| LIN L. and Lai K.O., TBC1D24 is a novel activity-induced synaptic protein in neurons that plays crucial role in dendritic spine morphogenesis, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| LIN L., Lyu Q., Fei E., Ip N.Y. and Lai K.O., The epilepsy and intellectual disability-related gene tbc1d24 encodes a novel synaptic protein that regulates dendritic spine morphogenesis in neuron , HKU State Key Laboratory Neuroscience Symposium 2016 and Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| LIN L., Lyu Q., FEI E., IP N.Y. and Lai K.O., The epilepsy and intellectual disability-related gene tbc1d24 encodes a novel synaptic protein that regulates dendritic spine morphogenesis in neuron, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| LIN L., Lyu Q., Fei E., Ip N.Y. and Lai K.O., The epilepsy and intellectual disability-related gene tbc1d24 encodes a novel synaptic protein that regulates dendritic spine morphogenesis in neuron, Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| LIN L., FEI E., IP N.Y. and Lai K.O., The epilepsy and intellectual disability-related gene tbc1d24 encodes a novel synaptic protein that regulates dendritic spine morphogenesis in neuron, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| LO H.Y.L., LIN L., Lyu Q. and Lai K.O., A potential role of NMDA receptor-dependent expression of Striatin-4 in dendritic spine maturation, HKU State Key Laboratory Neuroscience Symposium 2016 and Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| LO H.Y.L., LIN L., Lyu Q. and Lai K.O., A potential role of NMDA receptor-dependent expression of Striatin-4 in dendritic spine maturation, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| LO H.Y.L., LIN L., Lyu Q. and Lai K.O., A potential role of NMDA receptor-dependent expression of Striatin-4 in dendritic spine maturation, Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| LO H.Y.L., LIN L., Lyu Q. and Lai K.O., A potential role of NMDA receptor-dependent expression of Striatin-4 in dendritic spine maturation, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| Researcher : LIN W |
| List of Research Outputs |
| LIN W., Yip Y.L., LO K.W., Deng W. and Tsao G.S.W., Establishment of a new cell line of nasopharyngeal carcinoma, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| ZHANG J., Jia L.J., LIN W., Yip Y.L., Tsang C.M., Zhou Y., Zhu D., Deng W. and Tsao G.S.W., Significance of Epstein-Barr virus encoded Latent Membrane Protein 1-Induced mTOR Signaling in Nasopharyngeal Cells, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Researcher : LIU KL |
| List of Research Outputs |
| Alexandria A., LIU K.L., Chang R.C.C., Pearce R.K.B. and Gentleman S.M., Differential expression of galanin in the cholinergic basal forebrain of patients with Lewy body disorders., Acta Neuropathologica Communications. 2015, 3: 1-12. |
| LIU K.L., Hurry M.E.D., DeFelice J., Lai H.M., Pearce R.K.B., Wong G.T.C., Chang R.C.C. and Gentleman S.M., Bringing CLARITY to human brain: visualisation of Lewy pathology in three-dimensions. , Neuropathology and Applied Neurobiology. 2015, 1-15. |
| Lai H.M., LIU K.L., Ng W.L., DeFelice J., Lee W.S., LI H., LI W., NG H.M., Chang R.C.C., Lin B., Wu W. and Gentleman S.M., Rationalisation and validation of an acrylamide-free procedure in three-dimensional histological imaging, PloS One. 2016, 11: e0158628. |
| Researcher : LIU L |
| List of Research Outputs |
| LIU L., ZHAO Y. and Huang J., Precise Control of Gene Expression via Synthetic Gene Circuits, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| LIU L., ZHAO Y.F. and Huang J., Precise Control of Gene Expression via Synthetic Gene-Circuits, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Researcher : LIU Y |
| List of Research Outputs |
| HO C.C., Wang B., Wong Y.M.E., LIU Y., Hui C.C. and Sham M.H., Best Poster Award: Sufu regulates the cell cycle exit and differentiation of cochlear hair cell progenitors, 2016 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, CUHK, Hong Kong, June 11, 2016. . 2016. |
| HO C.C., Wang B., Wong Y.M.E., LIU Y., HUI C.C. and Sham M.H., Sufu regulates the cell cycle exit and differentiation of cochlear hair cell progenitors, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| LIANG Y., Wong Y.M.E., LIU Y., Krauss R.S., Xu P.X., Hui C.C. and Sham M.H., The role of Hedgehog receptor Cdo in controlling cochlear hair cell and pillar cell formation, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| LIANG Y., Wong Y.M.E., LIU Y., Hui C.C. and Sham M.H., The role of Hedgehog receptor Cdo in controlling cochlear hair cell and pillar cell formation, Hong Kong Inter-University Postgraduate symposium in Biochemical Sciences 2016. |
| LIU Y., Wang B., Wong Y.M.E., Hui C.C. and Sham M.H., The roles of Irx3 and Irx5 genes in inner ear patterning, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Researcher : LO HYL |
| List of Research Outputs |
| LIN L., LO H.Y.L., Lyu Q. and Lai K.O., A potential role of NMDA receptor-dependent expression of Striatin-4 (STRN4) in dendritic spine maturation, Gordon Research Conference "Cell Biology of the Neuron". 2016. |
| LO H.Y.L., LIN L., Lyu Q. and Lai K.O., A potential role of NMDA receptor-dependent expression of Striatin-4 in dendritic spine maturation, HKU State Key Laboratory Neuroscience Symposium 2016 and Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| LO H.Y.L., LIN L., Lyu Q. and Lai K.O., A potential role of NMDA receptor-dependent expression of Striatin-4 in dendritic spine maturation, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| LO H.Y.L., LIN L., Lyu Q. and Lai K.O., A potential role of NMDA receptor-dependent expression of Striatin-4 in dendritic spine maturation, Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| LO H.Y.L., LIN L., Lyu Q. and Lai K.O., A potential role of NMDA receptor-dependent expression of Striatin-4 in dendritic spine maturation, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| Researcher : LU S |
| List of Research Outputs |
| LU S., Identification and in vitro affinity maturation of HIV-1 envelope glycoprotein-specific early intermediate B cells isolated from immortalized human naïve B cell library, PhD Thesis, The University of Hong Kong. 2015. |
| Researcher : LUK TCS |
| List of Research Outputs |
| LUK T.C.S. and Ma S.K.Y., Identification of REX1 as a Regulator of Cancer Stemness in CD133+ Liver Cancer Stem Cells by Genome-wide DNA Methylation Analysis, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Researcher : Lai CH |
| List of Research Outputs |
| Chan Y.S. and Lai C.H., The Vestibular System: Our Sense of Balance, Human Physiology. 2015, 22: 706-719. |
| Chen C.W., Ma C.W., Botelho F.P., Lai C.H., Shum D.K.Y. and Chan Y.S., Early postnatal perturbation of GABAergic transmission the vestibular nucleus impacts on the spatial map and spatial navigation behaviors [Kobe, Japan. July 28-31, 2015] 2004-1-4, Proc. 38th Annual Meeting of Japan Neuroscience Society. 2015. |
| Researcher : Lai KO |
| Project Title: | Investigating arginine methylation of synaptic proteins and its potential function in dendritic spine development |
| Investigator(s): | Lai KO |
| Department: | Physiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 07/2014 |
| Completion Date: | 07/2015 |
| Project Title: | Investigating the functional role of a novel synaptic protein TBC1D24 in activity-dependent spine morphogenesis |
| Investigator(s): | Lai KO |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2014 |
| Project Title: | Investigating the regulatory role of protein arginine methylation in dendritic spine development |
| Investigator(s): | Lai KO |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Early Career Scheme (ECS) |
| Start Date: | 01/2016 |
| Project Title: | Investigating the function of protein arginine methyltransferase PRMT5 in neuron: regulatory role in mRNA tranpsort and dendritic spine maturation |
| Investigator(s): | Lai KO |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2016 |
| Project Title: | Cell Biology of the Neuron; A potential role of NMDA receptor-dependent expression of Striatin-4 in dendritic spine development |
| Investigator(s): | Lai KO |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2016 |
| Completion Date: | 07/2016 |
| List of Research Outputs |
| CHAN H.L., Huang J. and Lai K.O., The Kinesin motor protein KIF5B regulates RNA trafficking and dendritic spine morphogenesis in hippocampal neuron, HKU State Key Laboratory Neuroscience Symposium 2016 and Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| CHAN H.L., Huang J. and Lai K.O., The Kinesin motor protein KIF5B regulates RNA trafficking and dendritic spine morphogenesis in hippocampal neuron, Inter-University Postgraduate Symposium in Biochemical Sciences . 2016. |
| CHAN H.L., Huang J. and Lai K.O., The kinesin motor protein KIF5B regulates RNA trafficking and dendritic spine morphogenesis in hippocampal neuron, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| CHAN H.L., Huang J. and Lai K.O., The kinesin motor protein KIF5B regulates RNA trafficking and dendritic spine morphologenesis in hippocampal neuron, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| LIN L., LO H.Y.L., Lyu Q. and Lai K.O., A potential role of NMDA receptor-dependent expression of Striatin-4 (STRN4) in dendritic spine maturation, Gordon Research Conference "Cell Biology of the Neuron". 2016. |
| LIN L. and Lai K.O., TBC1D24 is a novel activity-induced synaptic protein in neurons that plays crucial role in dendritic spine morphogenesis, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| LIN L., Lyu Q., Fei E., Ip N.Y. and Lai K.O., The epilepsy and intellectual disability-related gene tbc1d24 encodes a novel synaptic protein that regulates dendritic spine morphogenesis in neuron , HKU State Key Laboratory Neuroscience Symposium 2016 and Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| LIN L., Lyu Q., FEI E., IP N.Y. and Lai K.O., The epilepsy and intellectual disability-related gene tbc1d24 encodes a novel synaptic protein that regulates dendritic spine morphogenesis in neuron, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| LIN L., Lyu Q., Fei E., Ip N.Y. and Lai K.O., The epilepsy and intellectual disability-related gene tbc1d24 encodes a novel synaptic protein that regulates dendritic spine morphogenesis in neuron, Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| LIN L., FEI E., IP N.Y. and Lai K.O., The epilepsy and intellectual disability-related gene tbc1d24 encodes a novel synaptic protein that regulates dendritic spine morphogenesis in neuron, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| LO H.Y.L., LIN L., Lyu Q. and Lai K.O., A potential role of NMDA receptor-dependent expression of Striatin-4 in dendritic spine maturation, HKU State Key Laboratory Neuroscience Symposium 2016 and Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| LO H.Y.L., LIN L., Lyu Q. and Lai K.O., A potential role of NMDA receptor-dependent expression of Striatin-4 in dendritic spine maturation, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| LO H.Y.L., LIN L., Lyu Q. and Lai K.O., A potential role of NMDA receptor-dependent expression of Striatin-4 in dendritic spine maturation, Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| LO H.Y.L., LIN L., Lyu Q. and Lai K.O., A potential role of NMDA receptor-dependent expression of Striatin-4 in dendritic spine maturation, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| Lai K.O. and Ip N.Y., Cdk5: a key player at neuronal synapse with diverse functions., Mini reviews in medicinal chemistry. 2015, 15: 390-395. |
| Lai K.O., Editorial Board member, Scientific Reports. 2016. |
| Lai K.O., Jordan B.A., Ma X.M., Srivastava D.P. and Tolias K., Lead Guest Editor, Neural Plasticity (Special Issue on "Molecular Mechanisms of Dendritic Spine Development and Plasticity"). 2015. |
| Lai K.O., Jordan B.A., Ma X.M., Srivastava D.P. and Tolias K.F., Molecular Mechanisms of Dendritic Spine Development and Plasticity., Neural Plasticity. 2016, 2016: 2078121. |
| Lai K.O., Review Editor, Frontiers in Molecular Neuroscience. 2016. |
| Lai K.O., Signaling mechanisms behind the development and plasticity of neuronal synapses, The 6th FAONS Congress (FAONS symposium——Synapse formation and circuit function – From genes to physiological and behavioral outcomes). 2015. |
| Liang Z., Ye T., Zhou X., Lai K.O., Fu A.K. and Ip N.Y., Cdk5 Regulates Activity-Dependent Gene Expression and Dendrite Development., Journal of Neuroscience. 2015, 35: 15127-15134. |
| TONG C.K.B., Lai K.O. and Cheung K.H., Gamma-secretase cleaves stromal interaction molecule 1 induces capacitative calcium entry deficits in familial Alzheimer’s disease, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| TONG C.K.B., Lai K.O. and Cheung K.H., Gamma-secretase cleaves stromal interaction molecule 1 induces capacitative calcium entry deficits in familial Alzheimer’s disease, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| Researcher : Lai SWC |
| Project Title: | The role of sleep on fear learning and experience-dependent dendritic spine plasticity |
| Investigator(s): | Lai SWC |
| Department: | Physiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 07/2014 |
| Project Title: | Mechanism of fear associative learning in the frontal association cortex and its implications in schizophrenia |
| Investigator(s): | Lai SWC |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Early Career Scheme (ECS) |
| Start Date: | 10/2015 |
| Project Title: | New Advances in Optical Imaging of Live Cells and Organisms ; In vivo imaging of dendritic spines in learning and unlearning |
| Investigator(s): | Lai SWC |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 12/2015 |
| Completion Date: | 12/2015 |
| Project Title: | The role of sleep on fear learning and dendritic spine plasticity |
| Investigator(s): | Lai SWC, Cheung WH |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2016 |
| Project Title: | Cue-specific dendritic spine plasticity of fear conditioning and extinction in the mouse auditory cortex |
| Investigator(s): | Lai SWC |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2016 |
| Project Title: | Mechanisms underlying the antidepressant effects of ketamine in an animal model of depression: the role of dendritic spines and interneurons |
| Investigator(s): | Lai SWC, Chang RCC, Lai KO |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 06/2016 |
| List of Research Outputs |
| Han L., Yanagawa Y., Lai S.W.C. and Chan Y.S., Manipulation of different cortical neuron subtypes with optogenetics [HK. May 18, 2016], Proc. Neuroscience Symposium 2016 & Scientific Conference of The Hong Kong Society of Neurosciences. 2016, 34. |
| Han L., Yanagawa Y., Lai S.W.C. and Chan Y.S., Manipulation of different cortical neuron subtypes with optogenetics, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| Lai S.W.C., Dendritic Spine Plasticity in Depression , 11th International Symposium on Healthy Aging. 2016. |
| Lai S.W.C., In vivo imaging of dendritic spines in learning and unlearning, 2015 Cold Spring Harbor Asia Conference: New Advances In Optical Imaging Of Live Cells & Organisms. 2015. |
| Lai S.W.C., Intravital imaging of dendritic spines in learning and memory, The 6th FAONS Congress and The 11th Biennial Conference of CNS. 2015. |
| NG H.L.L., HUANG Y., Chang R.C.C. and Lai S.W.C., Altered Dendritic Spine Plasticity in a Mouse Depression Model, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| NG H.L.L., Chang R.C.C. and Lai S.W.C., Altered dendritic spine plasticity in a mouse depression model, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| NG H.L.L., Chang R.C.C. and Lai S.W.C., Dendritic spine plasticity in depression animal model, CNRS - Conférences Jacques Monod: Optical imaging of brain connectivity: from synapses to networks in action. 2016. |
| NG H.L.L., HUANG Y., Chang R.C.C. and Lai S.W.C., Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences, Altered dendritic spine plasticity in a mouse depression model. 2016. |
| YOU R., Cheng S.Y., Hung H.L.C., Ho Y.S., Lai S.W.C. and Chang R.C.C., Investigating the effects of silica nanoparticles on affective and cognitive behaviors and on synapse in vivo and in vitro. , International Alzheimer’s Disease Conference 2016. 64. |
| Researcher : Lai WL |
| List of Research Outputs |
| SO P.Y., Lai W.L., Ma S.K.Y. and Ching Y.P., Overexpression of CD133 Promotes Tumorigenicity and Suppresses TAX1BP2 in Hepatocellular Carcinoma, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| SO P.Y., Lai W.L. and Ching Y.P., Overexpression of CD133 Promotes Tumourigenicity and Suppresses TAX1PB2 in Hepatocellular Carcinoma, In: EMBO, EMBL Symposium: Tumour Microenvironment and Signalling. Heidelberg, Germany, 2016. |
| Researcher : Lam MC |
| List of Research Outputs |
| Li T., Qi S., Unger M., Hou Y.N., Deng Q.W., Liu J., Lam M.C., Wang X.W., Xin D., Zhang P., Koch-Nolte F., Hao Q., Zhang H., Lee H.C. and Zhao Y.J., Immuno-targeting the multifunctional CD38 using nanobody, Scientific Reports. 2016, 6: 27055. |
| Researcher : Lam YM |
| List of Research Outputs |
| YANG X., Lui W.C., Lam Y.M. and Ng R.K., Study of epigenetic dysregulation in MLL-rearranged leukemia, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Researcher : Lau CYW |
| Project Title: | Structural role of the BRCA1-PALB2-BRCA2 complex in DNA repair |
| Investigator(s): | Lau CYW |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | AXA Research Fund |
| Start Date: | 08/2014 |
| Project Title: | Structural Role of the BRCA1-PALB2-BRCA2 Complex in DNA Repair |
| Investigator(s): | Lau CYW, Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 02/2015 |
| Completion Date: | 07/2016 |
| Project Title: | #2 Dynamic DNA and RNA Structures in Damage Responses & Cancer Conference; Molecular architecture of the Ub-PCNA/Pol η complex bound to DNA |
| Investigator(s): | Lau CYW |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 02/2016 |
| Completion Date: | 02/2016 |
| List of Research Outputs |
| Lau C.Y.W., Li Y., Zhang Q. and Huen M.S.Y., Molecular architecture of the Ub-PCNA/Pol η complex bound to DNA, Scientific Reports. 2015, 5: 15759. |
| Lau C.Y.W., Zhang Q., Gao Y., Liu Z., Li Y. and Huen M.S.Y., Structure of the human dimeric ATM kinase, Cell Cycle. 2016, 15: 1117-1124. |
| Researcher : Lau PY |
| List of Research Outputs |
| Li S.K., TANG H.C., Lau P.Y., Zhou Y. and Ching Y.P., HBx targets centrosomal protein TAX1BP2 to promote genomic instability., Cell Symposium – Human Genomics. 2015. |
| Li S.K., TANG H.C., Lau P.Y., Zhou Y. and Ching Y.P., HBx targets centrosomal protein TAX1BP2 to promote genomic instability, In: Genome Institute of Singapore, A*Star, Cell Symposium - Human Genomic, Singapore. 2015. |
| Researcher : Lee CW |
| Project Title: | Neuroscience 2015; A novel cell-based serological assay for myasthenia gravis using Xenopus tissue cultures |
| Investigator(s): | Lee CW |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 10/2015 |
| Completion Date: | 10/2015 |
| Project Title: | Live imaging of acetylcholine receptor trafficking at developing neuromuscular junctions |
| Investigator(s): | Lee CW |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2016 |
| List of Research Outputs |
| Lee C.W., A novel cell-based serological assay for myasthenia gravis using Xenopus tissue cultures, Neuroscience 2015, Society for Neurosciences. 2015. |
| Lee C.W., Editorial Board, Frontiers in Synaptic Neuroscience. 2015. |
| Lee C.W., Regulation of acetylcholine receptor trafficking in neuromuscular development and disease, 8th FAOPS Congress 2015. 2015. |
| Lee C.W., Regulation of acetylcholine receptor trafficking in neuromuscular development and disease, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| Lee C.W., Scientific Imaging Competition Merit Award, The University of Hong Kong. 2015. |
| Researcher : Lee SMY |
| List of Research Outputs |
| Zhang L.Q., Sa F., Chong C.M., Wang Y.S., Zhou Z.Y., Chang R.C.C., Chang S.W., Hoi P.M. and Lee S.M.Y., Schisantherine A protects against 6-OHDA-induced dopaminergic neuron damage in zebrafish and cytotoxicity in SH-SY5Y cells through the ROS/NO and AKT/GSK3b pathways, Journal of Ethnopharmacology. 2015, 170: 8-15. |
| Researcher : Leung KKH |
| List of Research Outputs |
| Leung K.K.H., In Vitro Fertilization Facilitates Mouse Research, Laboratory Animal Unit, The University of Hong Kong. 2015. |
| Researcher : Li B |
| Project Title: | International Conference on Antimicobial Agents and Chemtherapy; Identification of miR-29c/FBXO31 as a key regulatory mechanism in esophageal cancer chemoresistance |
| Investigator(s): | Li B |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2015 |
| Completion Date: | 08/2015 |
| List of Research Outputs |
| Li B., XU W., Guan X., Qin Y...R..., Law S.Y.K., Lee N.P.Y., Chan K.T., Tam P.Y., Li Y.Y., Chan K.W., Yuen H...F..., Tsao G.S.W., He Q...Y... and Cheung A., Competitive Binding Between Id1 and E2F1 to Cdc20 Regulates E2F1 Degradation and Thymidylate Synthase Expression to Promote Esophageal Cancer Chemoresistance, Clinical Cancer Research. 2016, 22: 1243-1255. |
| Li B., Xu W., Liu J. and Cheung A., Identification of miR-29c/FBXO31 as a key regulatory mechanism in esophageal cancer chemoresistance, International Conference on Antimicrobial Agents and Chemotherapy, Valencia, Spain, August 04-06, 2015. |
| Xu W., Li B. and Cheung A., Role of miR-29c in modulating the paracrine crosstalk between esophageal cancer cells and stromal fibroblasts in the tumor microenvironment, International Conference on Antimicrobial Agents and Chemotherapy, Valencia, Spain, August 04-06, 2015. |
| Researcher : Li L |
| List of Research Outputs |
| KHONG M.L., Li L., LU B., Watt R.M. and Tanner J.A., Determining proteins that specifically bind to polyphosphate in osteoblasts, Inorganic polyphosphate (polyP) physiology. Biochemical Society Hot Topic Event, London, UK. 2015. |
| KHONG M.L., Li L. and Tanner J.A., Elucidating the Functional Implications of Polyphosphate-protein Interactions, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, Chinese University of Hong Kong, Hong Kong. 2016. |
| Li L., KHONG M.L., Lu B., Buchet R., Watt R.M. and Tanner J.A., Long-chain inorganic polyphosphate is highly enriched in osteoblastic matrix vesicles., 40th FEBS Congress 2015 “The Biochemical Basis of Life”, Berlin, Germany (2015).. 2015. |
| Li L., KHONG M.L., Mebarek R., Buchet R. and Tanner J.A., Long-chain polyphosphate is enriched in mineralized osteoblasts and matrix vesicles, Inorganic polyphosphate (polyP) physiology, Biochemistry Society Hot Topic Event, London, UK. 2015. |
| Researcher : Li NF |
| List of Research Outputs |
| XU W., Li N.F. and Chen J., Apical Na+ is required for decreasing transepithelial Na+ current of cultured pig tracheal epithelia by the apical Krebs solution, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| XU W., Li N.F. and Chen J., Contact-dependent virulence of P. aeruginosa is required for elevating paracellular conductance of cultured pig tracheal epithelia, 29th Annual North American Cystic Fibrosis Conference. 2015. |
| XU W., Li N.F. and Chen J., Effects of the apical Krebs solution on ion transport of cultured pig tracheal epithelia, American Thoracic Society (ATS) 2016 International Conference. 2016. |
| XU W., Li N.F. and Chen J., Effects of the apical Krebs solution on ion transport of cultured pig tracheal epithelia, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| ZHU S., XU W., Li N.F. and Chen J., Roles of bicarbonate ion in ion transport and bacterial killing of cultured pig tracheal epithelia, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Researcher : Li RA |
| Project Title: | Cell-based Heart Regeneration |
| Investigator(s): | Li RA, Boheler KR, Chan BP, Chan CWY, Chan GCF, Chien KR, Lee HC, Yue J, Ng RK, Ngan AHW |
| Department: | Medicine |
| Source(s) of Funding: | Theme-based Research Scheme |
| Start Date: | 09/2011 |
| Project Title: | Human WT1 epicardial progenitor cells |
| Investigator(s): | Li RA |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2013 |
| Project Title: | Stem Cell and Regenerative Medicine |
| Investigator(s): | Li RA, Chan GCF, Tse HF |
| Department: | Physiology |
| Source(s) of Funding: | Seed Funding for Strategic Research Theme |
| Start Date: | 06/2013 |
| Project Title: | Engineering Calcium Homeostasis of hESC-derived cardiomyocytes |
| Investigator(s): | Li RA |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 07/2013 |
| Project Title: | Ontogenic combinatorial conditioning of 3D human pluripotent stem cell ventricular models for facilitated maturation |
| Investigator(s): | Li RA |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 07/2014 |
| Completion Date: | 12/2015 |
| List of Research Outputs |
| Chan H.Y.S., Keung W.W.Y., Li R.A., Miller A.L. and Webb S.E., Morphometric Analysis of Human Embryonic Stem Cell-Derived Ventricular Cardiomyocytes: Determining the Maturation State of a Population by Quantifying Parameters in Individual Cells, Stem Cells International. 2015, 2015: 1-13. |
| WONG N.C.S., Keung W.W.Y., Chow M.Z.Y., WONG O.T. and Li R.A., Maturation of Human Pluripotent Stem Cell Derived Cardiomyocyte, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| WONG N.C.S., Chow M.Z.Y., Keung W.W.Y. and Li R.A., Maturation of hPSC-CMs in Bioenergetics driven by Oleic Acid and PPARα agonist, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Researcher : Li SK |
| Project Title: | Transcriptome Analysis of Tumor Suppressor Gene TAX1BP2 by Next-Generation Sequencing |
| Investigator(s): | Li SK, Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2014 |
| Completion Date: | 10/2015 |
| Project Title: | Cell Symposium- Human Genomics; HBx targets centrosomal protein TAX1BP2 to promote genomic instability |
| Investigator(s): | Li SK |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2015 |
| Completion Date: | 11/2015 |
| List of Research Outputs |
| Li S.K., TANG H.C., Lau P.Y., Zhou Y. and Ching Y.P., HBx targets centrosomal protein TAX1BP2 to promote genomic instability., Cell Symposium – Human Genomics. 2015. |
| Li S.K., TANG H.C., Lau P.Y., Zhou Y. and Ching Y.P., HBx targets centrosomal protein TAX1BP2 to promote genomic instability, In: Genome Institute of Singapore, A*Star, Cell Symposium - Human Genomic, Singapore. 2015. |
| Researcher : Li YY |
| List of Research Outputs |
| Li B., XU W., Guan X., Qin Y...R..., Law S.Y.K., Lee N.P.Y., Chan K.T., Tam P.Y., Li Y.Y., Chan K.W., Yuen H...F..., Tsao G.S.W., He Q...Y... and Cheung A., Competitive Binding Between Id1 and E2F1 to Cdc20 Regulates E2F1 Degradation and Thymidylate Synthase Expression to Promote Esophageal Cancer Chemoresistance, Clinical Cancer Research. 2016, 22: 1243-1255. |
| Researcher : Lian F |
| List of Research Outputs |
| LI T., Lian F., Xie S., DU Y. and Qian C., Molecular insights into histone H3 ubiquitination dependent maintenance DNA methylation, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Lian F., Xie S. and Qian C., Crystal structure and SUMO binding of Slx1-Slx4 complex, Scientific Reports. 2016, 6: 19331. |
| Researcher : Lim B |
| List of Research Outputs |
| FRASER L.A., DIRKZWAGER R.M., LIANG S., Cheung Y.W., KINGHORN A.B., Lim B. and Tanner J.A., 3D printing aptamer based rapid diagnostic tests for the point of care diagnosis of malaria, Malaria in Melbourne (MiM), Monash University, Melbourne, Australia. 2015. |
| FRASER L.A., KINGHORN A.B., TANG S.L.M., Cheung Y.W., Lim B., LIANG S., DIRKZWAGER R.M. and Tanner J.A., Oligonucleotide Functionalised Microbeads: Indispensable Tools for High-Throughput Aptamer Selection, Molecules. 2015, 20: 21298-21312. |
| Researcher : Lim LW |
| Project Title: | Comparative study of potential brain target stimulation for cognitive improvement in aged animal model |
| Investigator(s): | Lim LW |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2016 |
| Project Title: | International Conference of Molecular Neurodegeneration; Brain pacemaker in medial prefrontal cortex enhances memory and hippocampal neuroplasticity in the aged brain |
| Investigator(s): | Lim LW |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2016 |
| Completion Date: | 05/2016 |
| List of Research Outputs |
| Heng B.C.A., Lim L.W., Wu W. and Zhang C., An overview of protocols for the neural induction of dental and oral stem cells in vitro, In: Antonios G. Mikos; John P. Fisher, Tissue Engineering Part B: Reviews . Mary Ann liebert, 2016, 22 (3): 220-250. |
| Hescham S., Jahanshahi A., Meriaux C., Lim L.W., Blokland A. and Temel Y., Behavioral effects of deep brain stimulation of different areas of the Papez circuit on memory- and anxiety-related functions, Behavioural Brain Research. 2015, 292: 353-360. |
| Lim L.W., Brain pacemaker in medial prefrontal cortex enhances memory and hippocampal neuroplasticity in the aged brain. (Selected Short Talk Speaker), The 4th International Conference on Molecular Neurodegeneration, Seoul, South Korea. . 2016. |
| Lim L.W., Brain pacemaker in medial prefrontal cortex enhances memory and hippocampal neuroplasticity in the aged brain. , The 4th International Conference on Molecular Neurodegeneration, Seoul, South Korea.. 2016. |
| Lim L.W., Brain pacemaker in medial prefrontal cortex enhances mood and memory in experimental animal models. (Invited Speaker), Research Seminar, School of Biomedical Sciences, the University of Hong Kong.. 2016. |
| Lim L.W., Deep brain stimulation from depression to dementia. (Honorary Lecturer), Asia-Pacific Summer School on Bio-Inspired Systems and Prosthetic Devices, National Tsing Hua University, Taiwan.. 2015. |
| Lim L.W., Deep brain stimulation of the medial prefrontal cortex: From antidepressant to memory enhancement. (Invited Guest Speaker), Neuroscience and Neurology Seminar Series, Center for Intelligent Signal and Imaging Research (CISIR), Universiti Teknologi Petronas, Malaysia.. 2015. |
| Lim L.W., Deep brain stimulation: A new treatment discovered for depression and memory enhancement. , Special Professorial Lecture Series, Sunway University, Malaysia. . 2015. |
| Lim L.W., Deep brain stimulation: New treatment for depression and dementia. (Special Professorial Lecture Series), Special Professorial Lecture Series, Sunway University, Malaysia.. 2015. |
| Lim L.W., Electrical Stimulation of the Prefrontal Cortex: from Antidepressant to Memory Enhancement Effects. (Invited Guest Speaker), “Strategic Research Theme on Biomedical Engineering and Nanotechnology”, Department of Electrical & Electronic Engineering”, the University of Hong Kong, Hong Kong.. 2015. |
| Lim L.W., From Basic Research to Functional Neurosurgery of Parkinson’s disease. (Invited Guest Speaker), The 11th International Symposium on Healthy Aging "Science and Aging: An Era of Discovery", Hong Kong.. 2016. |
| Lim L.W., From Basic Research to Functional Neurosurgery of Parkinson’s disease. , The 11th International Symposium on Healthy Aging, Hong Kong. . 2016. |
| Lim L.W., Medial prefrontal cortex stimulation: From antidepressant to memory enhancement. , Asia-Pacific Summer School on Bio-Inspired Systems and Prosthetic Devices, National Dong Hwa University, Taiwan.. 2015. |
| Lim L.W., Neuromodulation in Mood and Anxiety Behaviors. (Invited Guest Speaker), Departments of Neurosurgery and Neuroscience, Maastricht University, the Netherlands.. 2015. |
| Lim L.W., Neuromodulation in depressive-like behaviors. (Invited Guest Speaker), Clinical Neuroscience Meeting, jointly organized by the Mediterranean Neuroscience Society, European Graduate School of Neuroscience, Maastricht University, and Ondokuz Mayis University, Turkey.. 2015. |
| Lim L.W., Prefrontal cortex stimulation enhances antidepressant and memory functions in experimental models. (Invited Keynote Speaker), The 6th Medical Engineering Innovation3 Center International Symposium, Osaka University, Japan.. 2016. |
| Lim L.W., Prefrontal cortex stimulation enhances antidepressant and memory functions in experimental models. , The 6th Medical Engineering Innovation3 Center International Symposium, Osaka University, Japan.. 2016. |
| Lim L.W., Selected Person of the “Ten Malaysian Scientists Whose Research is making the World a Better Place”, SAYS, Malaysia.. 2015. |
| Lim L.W., Ten Outstanding Young Malaysian Award (Scientific and/or Technological Development), Junior Chamber International. 2015. |
| Yap M.S., Tang Y.Q., Yeo Y., Lim W.L., Lim L.W., Tan K.O., Richards M., Othman L., Poh C.L. and Heng B.C.A., Pluripotent Human embryonic stem cell derived neural lineages for in vitro modelling of enterovirus 71 infection and therapy, Virology Journal. 2016, 13. |
| Researcher : Lin B |
| Project Title: | Modulation of the PTEN/mTOR pathway enhances the survival of cone photoreceptors in retinal degeneration disorders |
| Investigator(s): | Lin B, Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 12/2013 |
| Completion Date: | 07/2016 |
| Project Title: | Cyclooxygenase-1 deletion enhances cone photoreceptor survival in retinal degeneration disorders |
| Investigator(s): | Lin B |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2014 |
| Completion Date: | 06/2016 |
| Project Title: | Ectopic expression of the light-sensitive protein melanopsin in rod photoreceptors prevents retinal degeneration |
| Investigator(s): | Lin B |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Completion Date: | 07/2016 |
| Project Title: | Cyclooxygenase-1 deletion promotes microglia quiescence and enhances cone photoreceptor survival in retinal degeneration disorders |
| Investigator(s): | Lin B, Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 06/2015 |
| Completion Date: | 07/2016 |
| Project Title: | Inhibition of colony-stimulating factor 1 receptor signaling in microglia delays the progression of the chronic neurodegeneration in retinitis pigmentosa |
| Investigator(s): | Lin B |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2015 |
| Completion Date: | 07/2016 |
| Project Title: | Inhibition of colony-stimulating factor 1 receptor (CSF1R) signaling in microglia delays the progression of the chronic neurodegeneration in retinitis pigmentosa |
| Investigator(s): | Lin B |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2016 |
| Completion Date: | 07/2016 |
| Project Title: | annual meeting of the association for research in vision and ophthalmology ; PTEN deletion enhances the survival of cone photoreceptors in retinal degeneration disorders |
| Investigator(s): | Lin B |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2016 |
| List of Research Outputs |
| LI T., Ren C., Huang L., Lin B., Pu M., Pickard G.E. and So K.F., The Dorsal Raphe Nucleus Receives Afferents From Alpha-Like Retinal Ganglion Cells and Intrinsically Photosensitive Retinal Ganglion Cells in the Rat, Investigative Opthalmology & Visual Science. 2015, 56: 8373. |
| Lai H.M., LIU K.L., Ng W.L., DeFelice J., Lee W.S., LI H., LI W., NG H.M., Chang R.C.C., Lin B., Wu W. and Gentleman S.M., Rationalisation and validation of an acrylamide-free procedure in three-dimensional histological imaging, PloS One. 2016, 11: e0158628. |
| Researcher : Lin Q |
| List of Research Outputs |
| Guo Z., Yu B., Ning B.T., Chan S., Lin Q., Li C.B., Huang J. and Chan G.C.F., Genetically modified "obligate" anaerobic Salmonella typhimurium as a therapeutic strategy for neuroblastoma, Journal of Hematology & Oncology. 2015, 8. |
| Researcher : Liong EC |
| List of Research Outputs |
| XIAO J., Liu Y.X., Xing F.Y., Leung T.M., Liong E.C. and Tipoe G.L., Bee’s honey attenuates non-alcoholic steatohepatitis-induced hepatic injury through the regulation of thioredoxin-interacting protein–NLRP3 inflammasome pathway, European Journal of Nutrition. 2016, 55: 1465-1477. |
| Researcher : Liu AJ |
| List of Research Outputs |
| Liu A.J., RAO Y., Cheung M.P.L., Hui M.N., Wu M.H., Niu B., Chan L.K., Cheah K.S.E. and Cheung M.C.H., Coordinated action of Nedd9 and Dlc1 in neural crest motility, Proceedings of Avian Model Systems 9: A New Integrative Platform. 2016. |
| RAO Y., Liu A.J., Cheung M.P.L., Chan L.K., Ng I.O.L. and Cheung M.C.H., Dlc1, a Rho GTPase-activating protein, is essential for cranial neural crest development, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| RAO Y., Liu A.J., Cheung M.P.L., Chan L.K., Ng I.O.L. and Cheung M.C.H., Dlc1, a Rho GTPase-activating protein, is essential for cranial neural crest development, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| Researcher : Liu B |
| Project Title: | Adult stem cell decline accelerates premature ageing in Zmpste24 deficient mice |
| Investigator(s): | Liu B, Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 08/2008 |
| Project Title: | Stem Cells 2009 Oxidative stress-mediated accelerated adult stem cell decline contributes to premature ageing in Zmpste24–/– mice |
| Investigator(s): | Liu B |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2009 |
| Project Title: | Quantitative mass spectrometry-based screening for SIRT1 deacetylating targets |
| Investigator(s): | Liu B, Zhou Z, Chu IK |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2012 |
| Project Title: | Role of Autophagy in Cellular Senescence and Laminopathy-based Premature Ageing |
| Investigator(s): | Liu B |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2013 |
| List of Research Outputs |
| GHOSH S., Liu B., Wang Y., Hao Q. and Zhou Z., Lamin A Is an Endogenous SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair, Cell Reports. 2015, 13: 1396-1406. |
| Researcher : Lui PY |
| List of Research Outputs |
| CHAUDHARY V., Zhang S., Yuen K.S., Li C., Lui P.Y., FUNG S.Y., WANG P., Chan C.P., Li D., Kok K.H., Liang M. and Jin D., Suppression of type I and type III interferon signalling by NSs protein of severe fever-with-thrombocytopenia syndrome virus through inhibition of STAT1 phosphorylation and activation, Journal of General Virology. 2015. |
| Lui P.Y., WONG L.Y.R., Fung C.L., Siu K.L., Yeung M.L., Yuen K.S., Chan C.P., Woo P.C.Y., Yuen K.Y. and Jin D., Middle East respiratory syndrome coronavirus M protein suppresses type I interferon expression through the inhibition of TBK1-dependent phosphorylation of IRF3, Emerging Microbes & Infections. 2016, 5: e39. |
| Researcher : Lyu Q |
| List of Research Outputs |
| LIN L., LO H.Y.L., Lyu Q. and Lai K.O., A potential role of NMDA receptor-dependent expression of Striatin-4 (STRN4) in dendritic spine maturation, Gordon Research Conference "Cell Biology of the Neuron". 2016. |
| LIN L., Lyu Q., Fei E., Ip N.Y. and Lai K.O., The epilepsy and intellectual disability-related gene tbc1d24 encodes a novel synaptic protein that regulates dendritic spine morphogenesis in neuron , HKU State Key Laboratory Neuroscience Symposium 2016 and Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| LIN L., Lyu Q., FEI E., IP N.Y. and Lai K.O., The epilepsy and intellectual disability-related gene tbc1d24 encodes a novel synaptic protein that regulates dendritic spine morphogenesis in neuron, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| LIN L., Lyu Q., Fei E., Ip N.Y. and Lai K.O., The epilepsy and intellectual disability-related gene tbc1d24 encodes a novel synaptic protein that regulates dendritic spine morphogenesis in neuron, Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| LO H.Y.L., LIN L., Lyu Q. and Lai K.O., A potential role of NMDA receptor-dependent expression of Striatin-4 in dendritic spine maturation, HKU State Key Laboratory Neuroscience Symposium 2016 and Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| LO H.Y.L., LIN L., Lyu Q. and Lai K.O., A potential role of NMDA receptor-dependent expression of Striatin-4 in dendritic spine maturation, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| LO H.Y.L., LIN L., Lyu Q. and Lai K.O., A potential role of NMDA receptor-dependent expression of Striatin-4 in dendritic spine maturation, Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| LO H.Y.L., LIN L., Lyu Q. and Lai K.O., A potential role of NMDA receptor-dependent expression of Striatin-4 in dendritic spine maturation, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| Researcher : MA SKY |
| List of Research Outputs |
| CHAN L.H. and Ma S.K.Y., PRMT6 Suppresses the Development of Hepatocellular Carcinoma via Up-regulation of ERKTFF1 Pathway, 20th Research Postgraduate Symposium. 2015. |
| LAU C.C. and Ma S.K.Y., Characterization of a novel oncogene follistatin-like 1 (FSTL1) in esophageal squamous cell carcinoma (ESCC), Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| LAU C.C. and Ma S.K.Y., Identification and Characterization of a Novel Oncogene Follistatin-Like 1 in Esophageal Squamous Cell Carcinoma, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| LUK T.C.S. and Ma S.K.Y., Identification of REX1 as a Regulator of Cancer Stemness in CD133+ Liver Cancer Stem Cells by Genome-wide DNA Methylation Analysis, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Lau Y.T., Lo J., CHENG Y.L.B., MA K.F., Lee M.F., Ng K.Y., CHAI S., Lin C., Tsang F.S., Ma S.K.Y., Ng I.O.L. and Lee K.W., Cancer-associated fibroblasts regulate tumor-initiating cell plasticity in hepatocellular carcinoma through c-Met/FRA1/HEY1 signaling, Cell Reports. 2016, 15: 1175-89. |
| Li J., CHEN J., Zeng T.T., He F., Chen S.P., Ma S.K.Y., Bi J., Zhu X.F. and Guan X., CD133+ liver cancer stem cells resist interferon-gamma induced autophagy, BMC Cancer. 2016, 16: 15. |
| MA S.K.Y., SHEN S., Ng V.C.W., An Y., Agata K., Lam Y.W. and Chan D., Phylogenetic Analysis of Planarian Collagens and their Roles in Regeneration, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Ma S.K.Y., CD133 cancer stem cells in hepatocellular carcinogenesis, 2015 School of Life Science and Technology Annual Symposium - Frontier of Cancer Research and Therapy Forum, ShanghaiTech University, Shanghai, China. 2015. |
| Ma S.K.Y., CD133 cancer stem cells in hepatocellular carcinogenesis, Symposium for Flow Cytometry, Hong Kong. 2015. |
| Ma S.K.Y., CD133 liver cancer stem cells, HKU-GIBH Symposium on Stem Cells and Regenerative Medicine, Guangzhou, China. 2015. |
| Ma S.K.Y., Exploiting ‘stemness’ as a cancer cell vulnerability, Hong Kong Society of Developmental Biology, City University of Hong Kong, Hong Kong. 2016. |
| Ma S.K.Y., Exploiting ‘stemness’ as a cancer cell vulnerability, Inaugural Symposium of School of Biomedical Sciences, The University of Hong Kong, Hong Kong. 2016. |
| Ma S.K.Y., Functional interplay of microRNA-1246 and Wnt/β-catenin in the pathogenesis of CD133+ hepatocellular carcinoma, Symposium 2015 of State Key Laboratory for Liver Research, Hong Kong, Hong Kong. 2015. |
| Ma S.K.Y., Targeting cancer stem cells for the treatment of hepatocellular carcinoma, 11th International Symposium on Healthy Aging, Hong Kong. 2016. |
| SO P.Y., Lai W.L., Ma S.K.Y. and Ching Y.P., Overexpression of CD133 Promotes Tumorigenicity and Suppresses TAX1BP2 in Hepatocellular Carcinoma, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Tong M. and Ma S.K.Y., ANXA3/JNK Signaling Promotes Self-Renewal and Tumor Growth, and Its Blockade Provides a Therapeutic Target for Hepatocellular Carcinoma, Shanghai Joint Forum 2015. 兩地三方學術會議 2015. |
| Researcher : Ma CW |
| Project Title: | Excitation-inhibition balance in central vestibular circuitry is critical to spatial recognition |
| Investigator(s): | Ma CW, Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2014 |
| Completion Date: | 07/2015 |
| List of Research Outputs |
| Bambach N., Bilicki M., Cao B., Bottger M., Charan K., Dinkins C., Elsanadidy E., Fischer J.M., Gopinath S.D., Govindaraghavan M., Konstantinides N., Ma C.W., Mainou B.A., Mitchell M., Neef L., Persson M.V., Ruy N., Ryan T., Schwartz K., Spear P., Stewart M.P., Thompson-Peer K.L. and Zupanc J., NextGenVOICES, Science. 2015, 349: 349, 24-27. |
| Chan Y.S., Botelho F.P., CHEN W., Ma C.W., Shi W. and Shum D.K.Y., Developmental mechanism underlying sensorimotor control of orienting behavior [Wuzhen, China. Sept. 20-23, 2015], Proc.5th FAONS Congress. 2015. |
| Chan Y.S., Han L., Li Y.H., Ma C.W. and Shum D.K.Y., Role of G-protein-coupled serotonin receptor on synaptic plasticity of excitatory transmission in the vestibular nucleus of rats ( USA) 236.03/L22 [Chicago. Oct. 15-19, 2015], Soc. Neuroscience Abstract. 2015. |
| Chen C.W., Ma C.W., Botelho F.P., Lai C.H., Shum D.K.Y. and Chan Y.S., Early postnatal perturbation of GABAergic transmission the vestibular nucleus impacts on the spatial map and spatial navigation behaviors [Kobe, Japan. July 28-31, 2015] 2004-1-4, Proc. 38th Annual Meeting of Japan Neuroscience Society. 2015. |
| JIANG Q., Ma C.W., Chen C.W., Shum D.K.Y. and Chan Y.S., Fluoxetine induces rejuvenation of plasticity in the vestibular system of adult rats IP106. [Kobe, Japan. July 28-31, 2015], Proc. 38th Annual Meeting of Japan Neuroscience Society. 2015. |
| JIANG Q., Ma C.W., CHEN W., Shum D.K.Y. and Chan Y.S., Fluoxetine induces restoration of plasticity in the adult vestibular system [25th Meeting of International Society for Neurochemistry Cairns, Australia. Aug. 23-27, 2015], Journal of Neurochemistry. 2015. |
| JIANG Y., Ma C.W., Wang J.J. and Chan Y.S., Orexin modulates inhibitory synaptic transmission of vestibular nuclear neurons in rats [HK. May 18, 2016], Proc. Neuroscience Symposium 2016 & Scientific Conference of The Hong Kong Society of Neurosciences. 2016, 37. |
| JIANG Y., Ma C.W., Wang J.J. and Chan Y.S., Orexin modulates inhibitory synaptic transmission of vestibular nuclear neurons in rats, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Role of perineuronal chondroitin sulfates and semaphorin 3A in the maturation of the vestibular circuitry [HK. March 12-13, 2016], Abstracts of 11th Int’l Symp. on Healthy Aging: Science and Aging – An Era of Discovery. 2016, 70. |
| KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Roles of perineuronal chondroitin sulfates and semaphorin 3A in the maturation of the vestibular circuitry, Abstracts of 11th Int’l Symp. on Healthy Aging: 70. 2016. |
| KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., The Regulatory Roles of Semaphorin 3A and Chondroitin Sulfates on Perineuronal Nets in the Developing Vestibular Circuitry, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., The Roles of Semaphorin 3A and Chondroitin Sulfates on Perineuronal Nets in Regulating the Development of Vestibular Circuitry, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| LI Z., Lam Y.L., Cham C.W., Ma C.W., Chan Y.S. and Shum D.K.Y., Axonal trafficking and localized trafficking of heparanase 1 [HK. March 12-13, 2016], Abstracts of 11th Int’l Symp. on Healthy Aging: Science and Aging – An Era of Discovery. 2016, 60. |
| LI Z., LAM Y.L., CHAM W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Axonal trafficking and localized trafficking of heparanase 1, Abstracts of 11th Int’l Symp. on Healthy Aging: 60. 2016. |
| LI Z., Ma C.W., Chan Y.S. and Shum D.K.Y., Axonal trafficking of heparanase 1, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| Shum D.K.Y., HAU W.F., Ma C.W. and Chan Y.S., Modulating sulfation of perineuronal chondroitins during vestibular compensatin [Seoul, Korea. Aug. 23-27, 2015], Proc. 9th InternationalConference on Proteoglycans & 10th Pan-Pacific Connective Tissue Societies Symposium. 2015. |
| Researcher : Ma SKY |
| Project Title: | Characterization and clinical evaluation of the metastasis-suppressing function of TP53INP1 in hepatocellular carcinoma |
| Investigator(s): | Ma SKY |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2012 |
| Project Title: | Hepatitis B virus promotes hepatocarcinogenesis through induction of CD133+ cancer stem cells/tumor-initiating cells |
| Investigator(s): | Ma SKY, Guan X |
| Department: | Clinical Oncology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 01/2013 |
| Completion Date: | 10/2016 |
| Project Title: | Significance of Annexin A3 in CD133+ Cancer-Initiating Cells-Driven Hepatocellular Carcinoma |
| Investigator(s): | Ma SKY, Chan KW |
| Department: | Clinical Oncology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2013 |
| Project Title: | Outstanding Young Researcher Award 2012-13 |
| Investigator(s): | Ma SKY |
| Department: | Anatomy |
| Source(s) of Funding: | Outstanding Young Researcher Award |
| Start Date: | 01/2014 |
| Project Title: | A multidisciplinary study on hepatic cancer stem cells |
| Investigator(s): | Ma SKY |
| Department: | Anatomy |
| Source(s) of Funding: | Croucher Innovation Awards |
| Start Date: | 04/2014 |
| Project Title: | miR-1246 and Wnt/β-catenin interaction in the control of CD133+ liver cancer stem cells driven hepatocellular carcinoma |
| Investigator(s): | Ma SKY |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2014 |
| Completion Date: | 08/2015 |
| Project Title: | Regulatory role of microRNA-1246 and Wnt/β-catenin pathway interaction in CD133+ liver cancer stem cells-driven hepatocellular carcinoma |
| Investigator(s): | Ma SKY |
| Department: | Anatomy |
| Source(s) of Funding: | Early Career Scheme (ECS) |
| Start Date: | 01/2015 |
| Project Title: | PRMT6 in the control of glucose metabolic reprogramming in CD133+ liver cancer stem cells |
| Investigator(s): | Ma SKY |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 03/2015 |
| Project Title: | A Multidisciplinary Study on CD133 Liver Cancer Stem Cells: Molecular Mechanisms, Clinical Relevance and Therapeutic Implications |
| Investigator(s): | Ma SKY, Guan X, Lo CM, Man K |
| Department: | Anatomy |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 06/2015 |
| Project Title: | PRMT6 regulates ERK1/2 signal transduction in liver cancer through CRAF |
| Investigator(s): | Ma SKY |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2016 |
| Project Title: | Establishment of a novel ANXA3 neutralizing antibody and its use, alone or in combination with sorafenib, as a potential therapeutic regimen against liver cancer |
| Investigator(s): | Ma SKY |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Translational and Applied Research |
| Start Date: | 05/2016 |
| List of Research Outputs |
| CHAN L.H. and Ma S.K.Y., PRMT6 Suppresses the Development of Hepatocellular Carcinoma via Up-regulation of ERKTFF1 Pathway, 20th Research Postgraduate Symposium. 2015. |
| LAU C.C. and Ma S.K.Y., Characterization of a novel oncogene follistatin-like 1 (FSTL1) in esophageal squamous cell carcinoma (ESCC), Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| LAU C.C. and Ma S.K.Y., Identification and Characterization of a Novel Oncogene Follistatin-Like 1 in Esophageal Squamous Cell Carcinoma, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| LUK T.C.S. and Ma S.K.Y., Identification of REX1 as a Regulator of Cancer Stemness in CD133+ Liver Cancer Stem Cells by Genome-wide DNA Methylation Analysis, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Lau Y.T., Lo J., CHENG Y.L.B., MA K.F., Lee M.F., Ng K.Y., CHAI S., Lin C., Tsang F.S., Ma S.K.Y., Ng I.O.L. and Lee K.W., Cancer-associated fibroblasts regulate tumor-initiating cell plasticity in hepatocellular carcinoma through c-Met/FRA1/HEY1 signaling, Cell Reports. 2016, 15: 1175-89. |
| Li J., CHEN J., Zeng T.T., He F., Chen S.P., Ma S.K.Y., Bi J., Zhu X.F. and Guan X., CD133+ liver cancer stem cells resist interferon-gamma induced autophagy, BMC Cancer. 2016, 16: 15. |
| MA S.K.Y., SHEN S., Ng V.C.W., An Y., Agata K., Lam Y.W. and Chan D., Phylogenetic Analysis of Planarian Collagens and their Roles in Regeneration, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Ma S.K.Y., CD133 cancer stem cells in hepatocellular carcinogenesis, 2015 School of Life Science and Technology Annual Symposium - Frontier of Cancer Research and Therapy Forum, ShanghaiTech University, Shanghai, China. 2015. |
| Ma S.K.Y., CD133 cancer stem cells in hepatocellular carcinogenesis, Symposium for Flow Cytometry, Hong Kong. 2015. |
| Ma S.K.Y., CD133 liver cancer stem cells, HKU-GIBH Symposium on Stem Cells and Regenerative Medicine, Guangzhou, China. 2015. |
| Ma S.K.Y., Exploiting ‘stemness’ as a cancer cell vulnerability, Hong Kong Society of Developmental Biology, City University of Hong Kong, Hong Kong. 2016. |
| Ma S.K.Y., Exploiting ‘stemness’ as a cancer cell vulnerability, Inaugural Symposium of School of Biomedical Sciences, The University of Hong Kong, Hong Kong. 2016. |
| Ma S.K.Y., Functional interplay of microRNA-1246 and Wnt/β-catenin in the pathogenesis of CD133+ hepatocellular carcinoma, Symposium 2015 of State Key Laboratory for Liver Research, Hong Kong, Hong Kong. 2015. |
| Ma S.K.Y., Targeting cancer stem cells for the treatment of hepatocellular carcinoma, 11th International Symposium on Healthy Aging, Hong Kong. 2016. |
| SO P.Y., Lai W.L., Ma S.K.Y. and Ching Y.P., Overexpression of CD133 Promotes Tumorigenicity and Suppresses TAX1BP2 in Hepatocellular Carcinoma, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Tong M. and Ma S.K.Y., ANXA3/JNK Signaling Promotes Self-Renewal and Tumor Growth, and Its Blockade Provides a Therapeutic Target for Hepatocellular Carcinoma, Shanghai Joint Forum 2015. 兩地三方學術會議 2015. |
| Researcher : NG GCT |
| List of Research Outputs |
| NG G.C.T., An investigation of the effects of the transaction factor PAX6 in an Alzheimer’s disease mouse model (CRND8), MPhil Thesis, The University of Hong Kong. 2015. |
| Researcher : NG HLL |
| List of Research Outputs |
| NG H.L.L., HUANG Y., Chang R.C.C. and Lai S.W.C., Altered Dendritic Spine Plasticity in a Mouse Depression Model, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| NG H.L.L., Chang R.C.C. and Lai S.W.C., Altered dendritic spine plasticity in a mouse depression model, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| NG H.L.L., Chang R.C.C. and Lai S.W.C., Dendritic spine plasticity in depression animal model, CNRS - Conférences Jacques Monod: Optical imaging of brain connectivity: from synapses to networks in action. 2016. |
| NG H.L.L., HUANG Y., Chang R.C.C. and Lai S.W.C., Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences, Altered dendritic spine plasticity in a mouse depression model. 2016. |
| Researcher : NG HM |
| List of Research Outputs |
| Lai H.M., LIU K.L., Ng W.L., DeFelice J., Lee W.S., LI H., LI W., NG H.M., Chang R.C.C., Lin B., Wu W. and Gentleman S.M., Rationalisation and validation of an acrylamide-free procedure in three-dimensional histological imaging, PloS One. 2016, 11: e0158628. |
| NG H.M., WEI L.Z., LAN L. and Huen M.S.Y., The K63-Deubiquitylating Enzyme BRCC36 Limits DNA Break Processing and Repair, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Researcher : Ng HWH |
| List of Research Outputs |
| AN L., JIANG Y., Ng H.W.H., CHEN J., GONG Q. and Huen M.S.Y., USP7 Enforces RNF169-dependent DNA Double-Strand Break Responses, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Researcher : Ng KY |
| Project Title: | Role of LOXL1 in CD133+ liver cancer stem cells driven hepatocellular carcinoma |
| Investigator(s): | Ng KY, Huen MSY, Ma SKY |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2015 |
| List of Research Outputs |
| Lau Y.T., Lo J., CHENG Y.L.B., MA K.F., Lee M.F., Ng K.Y., CHAI S., Lin C., Tsang F.S., Ma S.K.Y., Ng I.O.L. and Lee K.W., Cancer-associated fibroblasts regulate tumor-initiating cell plasticity in hepatocellular carcinoma through c-Met/FRA1/HEY1 signaling, Cell Reports. 2016, 15: 1175-89. |
| Researcher : Ng RK |
| Project Title: | The functional role of epigenetic memory in the differentiation plasticity of induced pluripotent stem cells |
| Investigator(s): | Ng RK |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2013 |
| Project Title: | The role of PRMT1 in activation of leukemia stem cell program in MLL-rearranged leukemia |
| Investigator(s): | Ng RK, Yiu SM, Chan LC |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Project Title: | Function of polycomb protein Bmi-1 in hematopoietic Wnt signaling pathway |
| Investigator(s): | Ng RK |
| Department: | Pathology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | Dysregulation of DNA methylation in MLL-rearranged leukemia |
| Investigator(s): | Ng RK |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2015 |
| Project Title: | The role of BMI-1 in regulation of JAK-STAT signaling pathway in human leukemia |
| Investigator(s): | Ng RK, Yiu SM |
| Department: | Biochemistry |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2015 |
| Project Title: | Epigenetic regulation of enhancer RNA in MLL-rearranged leukemia |
| Investigator(s): | Ng RK |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2016 |
| List of Research Outputs |
| Ng R.K., Epigenetics – the Ghost in Your Genes, HK Student Medical Journal (HKSMJ) Summer Research Programme. 2015. |
| Ng R.K., Identification of enhancers in notochordal lineage cells during intervertebral disc development, Advanced Study Workshop – The Regulome: Genome Architecture and Single-Cell Transcriptomeics. Hong Kong, 2016. |
| YANG X., Lui W.C., Lam Y.M. and Ng R.K., Study of epigenetic dysregulation in MLL-rearranged leukemia, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Researcher : Ng TW |
| Project Title: | Evaluating the effect of prostaglandin-E2 EP4 receptor signaling |
| Investigator(s): | Ng TW, Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 04/2015 |
| Completion Date: | 09/2016 |
| List of Research Outputs |
| HUANG C., Ho Y.S., Ng T.W., Irwin M.G., Chang R.C.C. and Wong G.T.C., Effect of continuous propofol infusion to rat on tau phosphorylation with or without temperature control., Journal of Alzheimer's Disease. 2016, 51: 213-226. |
| HUANG C., Ng T.W., Chu M.T., Chang R.C.C. and Wong G.T.C., The relationship between tau protein phosphorylation and surgical trauma in post operative cognitive dysfunction., The 11th International Conference on Healthy Aging. 2016, 62. |
| HUANG C., Ng T.W., Chu M.T., Chang R.C.C. and Wong G.T.C., The relationship of tau protein and inflammation within cognitive dysfunction induced by laparotomy, International Alzheimer’s Disease Conference 2016. 63. |
| HUANG C., Ng T.W., Chu M.T., Chang R.C.C. and Wong G.T.C., The role of tau protein and inflammation within cognitive dysfunction induced by laparotomy in young animal. , Annual Scientific Conference of The Hong Kong Society of Neuroscience 2016. 36. |
| LEUNG W.Y.Y., Ng T.W., Cheng S.Y., Hung H.L.C., Chu M.T., Chang R.C.C. and Wong G.T.C., The effect of sevoflurane in cognition. , The 11th International Conference on Healthy Aging. 2016, 71. |
| LEUNG W.Y.Y., Ng T.W., Cheng S.Y., Hung H.L.C., Chu M.T., Chang R.C.C. and Wong G.T.C., The effect of sevoflurane in cognitive and synaptic function, International Alzheimer’s Disease Conference . 2016, 64. |
| Researcher : Ng VCW |
| List of Research Outputs |
| MA S.K.Y., SHEN S., Ng V.C.W., An Y., Agata K., Lam Y.W. and Chan D., Phylogenetic Analysis of Planarian Collagens and their Roles in Regeneration, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Researcher : Ni Y |
| Project Title: | Three-Dimensional Super-Resolution Visualization of specific non-repetitive DNA in Single Mammalian Cells |
| Investigator(s): | Ni Y, Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2015 |
| List of Research Outputs |
| DUAN Z., Fung M.L., Ni Y., Wu W., Chan Y.S. and Huang J., Kinesin-1 regulates extrasynaptic NMDAR targeting and its reduction can confer neuroprotection, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| Researcher : Niu B |
| Project Title: | Whole genome identification of active core promoters, enhancers and insulators in mouse growth plate |
| Investigator(s): | Niu B, Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2010 |
| List of Research Outputs |
| Cheah K.S.E., Au Y.K., Niu B., Chan D. and Zhang M.Q., SPINE-GEL: a global gene expression library for the developing nucleus pulposus., Spine Week, Singapore, May 16-20, 2016. |
| Liu A.J., RAO Y., Cheung M.P.L., Hui M.N., Wu M.H., Niu B., Chan L.K., Cheah K.S.E. and Cheung M.C.H., Coordinated action of Nedd9 and Dlc1 in neural crest motility, Proceedings of Avian Model Systems 9: A New Integrative Platform. 2016. |
| Liu A.J., Ho S.H., Hui M.N., Cheung M.P.L., Wu M.H., Ho C.K.I., Niu B., Cheah K.S.E. and Cheung M.C.H., Sox9-dependent pathway in regulating neural crest cell motility, Neural Crest & Cranial Placodes Gordon Research Conference Development, Malformations and Cancers. 2015. |
| Researcher : Osorio Da Silva LA |
| List of Research Outputs |
| Osorio Da Silva L.A., Long F.E.I., Wu X.U.E.W.E.I. and Zhou Z., ISM1 plays a pro-tumorigenic role in breast cancer, Croucher Summer Course in Cancer Biology 2015. |
| Researcher : PAN W |
| List of Research Outputs |
| PAN W., HOR C.H.H., Hui C.C. and Sham M.H., Regulation of mammalian hindbrain neural stem cell/progenitor pool maintenance by β-catenin and Suppressor of fused (Sufu), Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Researcher : Pickard GE |
| List of Research Outputs |
| LI T., Ren C., Huang L., Lin B., Pu M., Pickard G.E. and So K.F., The Dorsal Raphe Nucleus Receives Afferents From Alpha-Like Retinal Ganglion Cells and Intrinsically Photosensitive Retinal Ganglion Cells in the Rat, Investigative Opthalmology & Visual Science. 2015, 56: 8373. |
| Researcher : Poon NYE |
| Project Title: | The effect of miR-200c on the electrophysiological maturation of human embryonic stem cell derived cardiomyocytes |
| Investigator(s): | Poon NYE, Boheler KR, Li RA |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2014 |
| List of Research Outputs |
| Wang Y., Li Z.C., Zhang P.I., Poon N.Y.E., Kong M.C.W., Boheler K.R., Huang Y. and Yao X., Nitric Oxide-cGMP-PKG Pathway Acts on Orai1 to Inhibit the Hypertrophy of Human Embryonic Stem Cell-Derived Cardiomyocytes, STEM CELLS. 2015, n/a-n/a. |
| Researcher : QIN Y |
| List of Research Outputs |
| Kwok C.T.D., LEUNG M.H., Qin J., QIN Y., Wang J.J., Lee C.Y.L. and Yao K.M., The Forkhead box transcription factor FOXM1 is required for the maintenance of cell proliferation and protection against oxidative stress in human embryonic stem cells, Stem Cell Research. 2016. |
| QIN Y., KOOHIMOGHADAM M., WANG P., Qin J. and Wang J.J., Machine learning based gene regulatory network inferring with genetics and epigenetics features, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Researcher : Qian C |
| Project Title: | Structural and Mechanistic Characterization of XPA-associated Complexes in Nucleotide Excision Repair Pathway |
| Investigator(s): | Qian C |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2012 |
| Completion Date: | 12/2015 |
| Project Title: | Structure-Based Mechanistic Insights into Timeless-Involved Replication Fork Protection |
| Investigator(s): | Qian C |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2013 |
| Project Title: | Structural and Mechanistic Studies of Human SLX4 Complex in Interstrand Crosslink Repair |
| Investigator(s): | Qian C |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2014 |
| Project Title: | Structural & Mechanistic Analysis of BAF Chromatin Remodeling Complex |
| Investigator(s): | Qian C |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2015 |
| Project Title: | the 4th Cold Spring Harbor Asia conference on Chromatin, Epigenetics and Transcription; Timeless interacts with PARP-1 to promote DNA Double-strand Break repair |
| Investigator(s): | Qian C |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2016 |
| Completion Date: | 05/2016 |
| Project Title: | Structural and Mechanistic Insights into DNMT1-mediated Maintenance DNA Methylation |
| Investigator(s): | Qian C |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2016 |
| List of Research Outputs |
| LI T., Lian F., Xie S., DU Y. and Qian C., Molecular insights into histone H3 ubiquitination dependent maintenance DNA methylation, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Lian F., Xie S. and Qian C., Crystal structure and SUMO binding of Slx1-Slx4 complex, Scientific Reports. 2016, 6: 19331. |
| Qian C., New Mechanistic Insights into DNMT1 Mediated DNA Methylation Maintenance, IAS Focused Program on Genome Damage and Stability. 2015. |
| Qian C., New Mechanistic Insights into DNMT1 Mediated Maintenance DNA Methylation, 6th Asia-Pacific NMR Symposium. 2015. |
| Qian C., New mechanistic Insights into PARP-1 mediated DNA Damage Response, Nanjing University. 2016. |
| XIE S., Mortuewicz O., Ma H., Poon R., Helleday T. and Qian C., Timeless interacts with PARP-1 to promote DNA repair, IAS Focused Program on Genome Damage and Stability . 2015. |
| Xie S., Mortusewicz O., Ma H., Herr P., Poon R., Helleday T. and Qian C., Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair, Molecular Cell. 2015. |
| Xie S., Mortusewicz O., Ma H., Poon R., Helleday T. and Qian C., Timeless interacts with PARP-1 to promote DNA Double-strand Break repair, 1st Cold Spring Harbor Asia conference on DNA Metabolism, Genomic Stability and Diseases . 2016. |
| Xie S., Mortusewicz O., Ma H., Poon R., Helleday H. and Qian C., Timeless interacts with PARP-1 to promote DNA Double-strand Break repair, 4th Cold Spring Harbor Asia conference on Chromatin, Epigenetics and Transcription . 2016. |
| Researcher : RAO Y |
| List of Research Outputs |
| Liu A.J., RAO Y., Cheung M.P.L., Hui M.N., Wu M.H., Niu B., Chan L.K., Cheah K.S.E. and Cheung M.C.H., Coordinated action of Nedd9 and Dlc1 in neural crest motility, Proceedings of Avian Model Systems 9: A New Integrative Platform. 2016. |
| RAO Y., Liu A.J., Cheung M.P.L., Chan L.K., Ng I.O.L. and Cheung M.C.H., Dlc1, a Rho GTPase-activating protein, is essential for cranial neural crest development, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| RAO Y., Liu A.J., Cheung M.P.L., Chan L.K., Ng I.O.L. and Cheung M.C.H., Dlc1, a Rho GTPase-activating protein, is essential for cranial neural crest development, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| Researcher : SHAH AM |
| List of Research Outputs |
| SHAH A.M., Chan W.C.W. and Chan D., The Role of Hypertrophic Chondrocytes and Cellular Stress in Intervertebral Disc Integrity and Degeneration, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Researcher : SHAH AN |
| List of Research Outputs |
| SHAH A.N., Hung H.L.C., CHENG S.Y. and Chang R.C.C., The effect of Oxyresveratrol on endoplasmic reticulum stress in Parkinson’s disease, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| SHAH A.N., Hung H.L.C., Cheng S.Y. and Chang R.C.C., The effect of oxyresveratrol on endoplasmic reticulum stress in Parkinson’s disease., Annual Scientific Conference of The Hong Kong Society of Neuroscience 2016. 50. |
| SHAH A.N., Hung H.L.C., Cheng S.Y. and Chang R.C.C., The role of oxyresveratrol in mitigating cellular toxicity in Parkinson’s disease, The 11th International Conference on Healthy Aging. 2016, 63. |
| Researcher : SHIU CC |
| List of Research Outputs |
| SHIU C.C., Cheung Y.W., DIRKZWAGER R.M., LIANG S., KINGHORN A.B., FRASER L.A., TANG S.L.M. and Tanner J.A., Aptamer-Directed DNA Tweezers, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, Chinese University of Hong Kong, Hong Kong. 2016. |
| SHIU C.C., Cheung Y.W., DIRKZWAGER R.M., LIANG S., KINGHORN A.B., FRASER L.A., TANG S.L.M. and Tanner J.A., Aptamer-mediated macromolecular recognition in facilitating DNA tweezer machinery, Aptamers in Bordeaux, Bordeaux, France. 2016. |
| SHIU C.C., Cheung Y.W., DIRKZWAGER R.M., LIANG S., KINGHORN A.B., FRASER L.A., TANG S.L.M. and Tanner J.A., Best Poster Prize: Aptamer-Directed DNA Tweezers, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, Chinese University of Hong Kong, Hong Kong 2016. 2016. |
| Researcher : SIT HM |
| List of Research Outputs |
| LI Z., SIT H.M. and Sham M.H., Ephs and ephrins in the Enteric Nervous System Development, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Researcher : SO HF |
| List of Research Outputs |
| SO H.F., Shiu S.Y.W. and Yao K.M., Glucose-regulated expression and processing of PDZD2 in mouse islets and rat INS-1E beta cells, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Researcher : SO PY |
| List of Research Outputs |
| SO P.Y., Lai W.L., Ma S.K.Y. and Ching Y.P., Overexpression of CD133 Promotes Tumorigenicity and Suppresses TAX1BP2 in Hepatocellular Carcinoma, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| SO P.Y., Lai W.L. and Ching Y.P., Overexpression of CD133 Promotes Tumourigenicity and Suppresses TAX1PB2 in Hepatocellular Carcinoma, In: EMBO, EMBL Symposium: Tumour Microenvironment and Signalling. Heidelberg, Germany, 2016. |
| Researcher : Sham MH |
| Project Title: | International Congress on Differentation and Cell Biology Neural-specific Cis-acting and Trans-acting Regulation of the Mouse Hoxb-3 Gene During Embryogenesis |
| Investigator(s): | Sham MH |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2000 |
| Project Title: | Outstanding Research Student Supervisor Award 2008-2009 |
| Investigator(s): | Sham MH |
| Department: | Biochemistry |
| Source(s) of Funding: | Outstanding Research Student Supervisor Award |
| Start Date: | 12/2009 |
| Project Title: | Visiting Research Professors Scheme 2010-11 |
| Investigator(s): | Sham MH |
| Department: | Biochemistry |
| Source(s) of Funding: | Visiting Research Professors Scheme |
| Start Date: | 09/2010 |
| Project Title: | The roles of Irx3 and Irx5 genes in mammalian inner ear morphogenesis |
| Investigator(s): | Sham MH |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2013 |
| Completion Date: | 12/2015 |
| Project Title: | Modulation of Notch1 receptor Intracellular Domain (NICD) stability by Eya1 phosphatase |
| Investigator(s): | Sham MH |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2015 |
| Project Title: | The roles of Suppressor of fused (Sufu) in the maintenance of mammalian neural progenitor cells |
| Investigator(s): | Sham MH |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Modulation of Notch Signaling by EYA1 in Breast Cancer |
| Investigator(s): | Sham MH |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2016 |
| Project Title: | The interactions of EyaI and Notch signaling in the branchial epithelia during mammalian craniofacial development |
| Investigator(s): | Sham MH |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2016 |
| List of Research Outputs |
| HO C.C., Wang B., Wong Y.M.E., LIU Y., Hui C.C. and Sham M.H., Best Poster Award: Sufu regulates the cell cycle exit and differentiation of cochlear hair cell progenitors, 2016 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, CUHK, Hong Kong, June 11, 2016. . 2016. |
| HO C.C., Wang B., Wong Y.M.E., LIU Y., HUI C.C. and Sham M.H., Sufu regulates the cell cycle exit and differentiation of cochlear hair cell progenitors, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| LI Z., SIT H.M. and Sham M.H., Ephs and ephrins in the Enteric Nervous System Development, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| LIANG Y., Wong Y.M.E., LIU Y., Krauss R.S., Xu P.X., Hui C.C. and Sham M.H., The role of Hedgehog receptor Cdo in controlling cochlear hair cell and pillar cell formation, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| LIANG Y., Wong Y.M.E., LIU Y., Hui C.C. and Sham M.H., The role of Hedgehog receptor Cdo in controlling cochlear hair cell and pillar cell formation, Hong Kong Inter-University Postgraduate symposium in Biochemical Sciences 2016. |
| LIU Y., Wang B., Wong Y.M.E., Hui C.C. and Sham M.H., The roles of Irx3 and Irx5 genes in inner ear patterning, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| PAN W., HOR C.H.H., Hui C.C. and Sham M.H., Regulation of mammalian hindbrain neural stem cell/progenitor pool maintenance by β-catenin and Suppressor of fused (Sufu), Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Szeto Y.Y., Chu K.H., Au Y.K., Huang Y.H., Wynn S., Mak A., Chan Y.S., Lovell-Badge R., Chan W.Y., Jauch R., Fritzsch B., Sham M.H. and Cheah K.S.E., The SOX9Y440X campomelic dysplasia mutation disrupts endolymph homeostasis., Gordon Research Conference: Fibroblast Growth Factors in Development & Disease. 2016. |
| WANG L., ZHANG H., Wong Y.M.E., Tsang S.L., Lendahl U. and Sham M.H., Notch signaling regulates pharyngeal ectoderm development, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Wong Y.M.E. and Sham M.H., Unraveling the genetics and pathogenesis of hearing loss in Eya1/Six1 associated Branchio-Oto-Renal syndrome and implications in therapeutic development. , Hearing Research Meeting in South University of Science and Technology of China, Shenzhen, China. 15 Dec 2015.. 2015. |
| Researcher : Sham PC |
| Project Title: | Replication study of susceptibility genes for colorectal cancer |
| Investigator(s): | Sham PC, Ho JWC, Cheng KK |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 10/2007 |
| Project Title: | Partner State Key Laboratory of Brain and Cognitive Sciences |
| Investigator(s): | Sham PC, So KF, Tan L |
| Department: | Centre for Genomic Sciences |
| Source(s) of Funding: | Matching Fund for State Key Laboratory (SKL) |
| Start Date: | 10/2008 |
| Project Title: | Visiting Research Professors Scheme 2009-10 |
| Investigator(s): | Sham PC |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | Visiting Research Professors Scheme |
| Start Date: | 09/2009 |
| Project Title: | Method and Software for Personal Risk Profiling of Complex Diseases |
| Investigator(s): | Sham PC, Cherny SS, Garcia-Barcelo MM, Kung AWC, Li M, Yang W |
| Department: | Psychiatry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2012 |
| Completion Date: | 12/2015 |
| Project Title: | Bioinformatics tools for identifying disease loci from exome sequencing data |
| Investigator(s): | Sham PC, Cherny SS, Garcia-Barcelo MM, Li M, Yang W |
| Department: | Psychiatry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2013 |
| Project Title: | Genomics |
| Investigator(s): | Sham PC, Chin FYL, Leung FCC |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | Seed Funding for Strategic Research Theme |
| Start Date: | 06/2013 |
| Project Title: | Cross Cultural Differences in Biased Cognition |
| Investigator(s): | Sham PC, Chen EYH, Toulopoulou T |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | ESRC/RGC Joint Research Scheme |
| Start Date: | 09/2013 |
| Project Title: | Statistical methods for characterizing the genetic component of polygenic diseases |
| Investigator(s): | Sham PC, Cherny SS |
| Department: | Psychiatry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Project Title: | Mutational spectrum for dilated cardiomyopathy in Hong Kong |
| Investigator(s): | Sham PC, Tse HF, Cherny SS, Garcia-Barcelo MM, Tang SM, Li M |
| Department: | Centre for Genomic Sciences |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2014 |
| Project Title: | A novel computational framework to identify transcription factor-DNA interaction for cancer genomics |
| Investigator(s): | Sham PC, Yao KM, Wong MP, Wang JJ |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 08/2014 |
| Project Title: | Schizophrenia-related de novo and compound heterozygous mutations |
| Investigator(s): | Sham PC, Chen EYH, Chang WC, Chan KW, Lee HME, Cherny SS, Li M |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2015 |
| Project Title: | Method and software tool for estimating and dissecting the heritability of complex diseases |
| Investigator(s): | Sham PC, Cherny SS, Li M |
| Department: | LKS Medical Faculty |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2015 |
| List of Research Outputs |
| LI J., Song Y., Sham P.C. and Li M., KGGSeq: a rapid and robust framework for large-scale whole genome sequencing downstream analysis with integrative functions, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| XIONG C., LI Y., Rai F.M., Sham P.C., ZHANG Y., Song Y., Cheah K.S.E. and Chan D., Genetic contribution to intervertebral discs integrity maintenance in mouse model, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Researcher : Shea GKH |
| Project Title: | Electrical stimulation of aligned nanofibers to enhance regeneration of the injured nerve |
| Investigator(s): | Shea GKH, Shum DKY, Hu Y |
| Department: | Orthopaedics & Traumatology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2014 |
| List of Research Outputs |
| Mun K.L., Tsui Y.P., Tai E.W., Chan Y.S., Shum D.K.Y. and Shea G.K.H., Rapid and efficient generation of neural progenitors from adult bone marrow stromal cells by hypoxic preconditioning, Stem Cells Research &Therapy. 2016, D16-00202. |
| Researcher : Shi L |
| List of Research Outputs |
| Shi L., Yu B., Cai C.H., Huang W., Zheng B., Smith D.K. and Huang J., Combined prokaryotic–eukaryotic delivery and expression of therapeutic factors through a primed autocatalytic positive-feedback loop, Journal of Controlled Release. 2016, 222: 130-140. |
| Researcher : Shiu SYW |
| Project Title: | Investigating potential signaling interactions between melatonin MT1 receptor and melatonin-related GPR50 receptor, and profiling melatonin-induced genome-wide transcriptional changes in prostate cancer |
| Investigator(s): | Shiu SYW |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2014 |
| Project Title: | Exploring melatonin receptor signaling in human retinal pigment epithelial cells |
| Investigator(s): | Shiu SYW |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 04/2015 |
| List of Research Outputs |
| SO H.F., Shiu S.Y.W. and Yao K.M., Glucose-regulated expression and processing of PDZD2 in mouse islets and rat INS-1E beta cells, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Researcher : Shum DKY |
| Project Title: | 30th Annual Conference of Society for Neuroscience Effects of Chondroitin Sulfate Supplements on Regeneration of Bridged Sciatic Nerves |
| Investigator(s): | Shum DKY |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2000 |
| Project Title: | 31st Annual Meeting of Society for Neuroscience Expression of Chondroitin 6-sulfotransferase mRNA and the Sulfation Product in Post-crush Sciatic Nerves of Adult Rats |
| Investigator(s): | Shum DKY |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2001 |
| Project Title: | Expression of heparanase in the injured spinal cord |
| Investigator(s): | Shum DKY |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2003 |
| Project Title: | 33rd Annual Conference of the Society for Neuroscience Spatiotemporal Expression of Chondroitin 6-Sulfotransferase (C6ST) In Regeneration of Crush-injured Sciatic Nerves of Adult Rats C6ST Expression in Sciatic Nerve Explant Culture of Adult Rats |
| Investigator(s): | Shum DKY |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2003 |
| Project Title: | Expression of chondroitin sulfotransferases in the injured spinal cord |
| Investigator(s): | Shum DKY |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2004 |
| Project Title: | Proteoglycans in Signaling Heparan Sulfate/Syndecan-1 Modulates the Balance between Proteinase and Anti-Proteinase in Bronchiectasis |
| Investigator(s): | Shum DKY |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2005 |
| Project Title: | From bone marrow stromal cells to Schwann cells – in vitro route to specification and utility in re-myelination therapy |
| Investigator(s): | Shum DKY, Chan YS |
| Department: | Biochemistry |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2012 |
| Project Title: | Tuning sulfation of chondroitins at perineuronal nets regulate plasticity of central vestibular synapse |
| Investigator(s): | Shum DKY, Chan YS |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2013 |
| Project Title: | Neuroscience 2015; Role of G-protein-coupled serotonin receptor on synaptic plasticity of excitatory transmission in the vestibular nucleus of rats |
| Investigator(s): | Shum DKY |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 10/2015 |
| Completion Date: | 10/2015 |
| List of Research Outputs |
| CHOW W.H., CHAM W.C., Chan Y.S. and Shum D.K.Y., Role of Proheparanase in Regulating Synaptic Plasticity in Rat Hippocampus, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| CHOW W.H., Chan Y.S. and Shum D.K.Y., Roles of Neuronal and Astrocytic Proheparanase in Regulating Synaptic Strength in Rat Hippocampus, 11th International Symposium on Healthy Aging. 2016. |
| CHOW W.H., Chan Y.S. and Shum D.K.Y., Roles of Neuronal and Astrocytic Proheparanase in Regulating Synaptic Strength in Rat Hippocampus, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Cai S., Chan Y.S. and Shum D.K.Y., Derivation of stable Schwann cells from human bone marrow stromal cells [25th Meeting of International Society for Neurochemistry. Cairns, Australia. Aug. 23-27, 2015], Journal of Neurochemistry. 2015. |
| Cai S., Han L., Ao Q., Chan Y.S. and Shum D.K.Y., Induced pluripotent stem cell-derived sensory neurons for fate commitment of bone marrow-derived Schwann cells – Utilization in re-myelination therapy , Stem Cells Translational Medicine. 2016, 5: 1-13. |
| Cai S., Chan Y.S. and Shum D.K.Y., Induced pluripotent stem cell-derived sensory neurons for in vitro specification of Schwann cells with potential for re-myelination therapy [HK. March 12-13, 2016], Abstracts of 11th Int’l Symp. on Healthy Aging: Science and Aging – An Era of Discovery. 2016, 61. |
| Cai S., Chan Y.S. and Shum D.K.Y., Small molecule approach to differentiation of human induced pluripotent stem cells to sensory neurons [HK. May 18, 2016], Proc. Neuroscience Symposium 2016 & Scientific Conference of The Hong Kong Society of Neurosciences. 2016, 30. |
| Cai S., Han L., Chan Y.S. and Shum D.K.Y., Small molecule approach to differentiation of human induced pluripotent stem cells to sensory neurons, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| Chan Y.S., Botelho F.P., CHEN W., Ma C.W., Shi W. and Shum D.K.Y., Developmental mechanism underlying sensorimotor control of orienting behavior [Wuzhen, China. Sept. 20-23, 2015], Proc.5th FAONS Congress. 2015. |
| Chan Y.S., Han L., Li Y.H., Ma C.W. and Shum D.K.Y., Role of G-protein-coupled serotonin receptor on synaptic plasticity of excitatory transmission in the vestibular nucleus of rats ( USA) 236.03/L22 [Chicago. Oct. 15-19, 2015], Soc. Neuroscience Abstract. 2015. |
| Chen C.W., Ma C.W., Botelho F.P., Lai C.H., Shum D.K.Y. and Chan Y.S., Early postnatal perturbation of GABAergic transmission the vestibular nucleus impacts on the spatial map and spatial navigation behaviors [Kobe, Japan. July 28-31, 2015] 2004-1-4, Proc. 38th Annual Meeting of Japan Neuroscience Society. 2015. |
| Chow G.H., Cham W.C., Chan Y.S. and Shum D.K.Y., Role of proheparanase in regulating synaptic plasticity in rat hippocampus [Seoul, Korea. Aug. 23-27, 2015], Proc. 9th International Conference on Proteoglycans & 10th Pan-Pacific Connective Tissue Societies Symposium. 2015. |
| Chow W.H., Cham W.C., Chan Y.S. and Shum D.K.Y., Role of neuronal and astrocytic proheparanase in regulating synaptic strength in rat hippocampus [HK. March 12-13, 2016], Abstracts of 11th Int’l Symp. on Healthy Aging: Science and Aging – An Era of Discovery. 2016, 69. |
| HAU W.F., Chan Y.S. and Shum D.K.Y., Change in sulfation patterns of chondroitin associated with the plastic changes in the rat brainstem [HK. March 12-13, 2016], Abstracts of 11th Int’l Symp. on Healthy Aging: Science and Aging – An Era of Discovery. 2016, 68. |
| HAU W.F., Chan Y.S. and Shum D.K.Y., Differential sulfation of chondroitins in the brain extracellular matrix regulates neuroplasticity, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| HAU W.F., Chan Y.S. and Shum D.K.Y., Dynamics of chondroitin sulfation in the rat brain during development and vestibular compensation, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| JIANG Q., Shum D.K.Y. and Chan Y.S., Antidepressant re-opens the plasticity of vestibular-mediated navigation in the adult, Abstracts of 11th Int’l Symp. on Healthy Aging: Science and Aging – An Era of Discovery. 2016, 48. |
| JIANG Q., Shum D.K.Y. and Chan Y.S., Antidepressant reinstates the plasticity in the adult vestibular nucleus, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| JIANG Q., Ma C.W., Chen C.W., Shum D.K.Y. and Chan Y.S., Fluoxetine induces rejuvenation of plasticity in the vestibular system of adult rats IP106. [Kobe, Japan. July 28-31, 2015], Proc. 38th Annual Meeting of Japan Neuroscience Society. 2015. |
| JIANG Q., Ma C.W., CHEN W., Shum D.K.Y. and Chan Y.S., Fluoxetine induces restoration of plasticity in the adult vestibular system [25th Meeting of International Society for Neurochemistry Cairns, Australia. Aug. 23-27, 2015], Journal of Neurochemistry. 2015. |
| KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Role of perineuronal chondroitin sulfates and semaphorin 3A in the maturation of the vestibular circuitry [HK. March 12-13, 2016], Abstracts of 11th Int’l Symp. on Healthy Aging: Science and Aging – An Era of Discovery. 2016, 70. |
| KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Roles of perineuronal chondroitin sulfates and semaphorin 3A in the maturation of the vestibular circuitry, Abstracts of 11th Int’l Symp. on Healthy Aging: 70. 2016. |
| KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., The Regulatory Roles of Semaphorin 3A and Chondroitin Sulfates on Perineuronal Nets in the Developing Vestibular Circuitry, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., The Roles of Semaphorin 3A and Chondroitin Sulfates on Perineuronal Nets in Regulating the Development of Vestibular Circuitry, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Combination of uniaxial chitosan nanofibers and immobilized chondroitinase ABC improves axonal regrowth in vitro, 11st International Symposium on Healthy Aging: Science and Aging: An Era of Discovery. 2016. |
| Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Combination of uniaxial chitosan nanofibers and immobilized chondroitinase ABS improves axonal regrowth in vitro [HK. March 12-13, 2016], Abstracts of 11th Int’l Symp. on Healthy Aging: Science and Aging – An Era of Discovery. 2016, 60. |
| LI Z., Lam Y.L., Cham C.W., Ma C.W., Chan Y.S. and Shum D.K.Y., Axonal trafficking and localized trafficking of heparanase 1 [HK. March 12-13, 2016], Abstracts of 11th Int’l Symp. on Healthy Aging: Science and Aging – An Era of Discovery. 2016, 60. |
| LI Z., LAM Y.L., CHAM W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Axonal trafficking and localized trafficking of heparanase 1, Abstracts of 11th Int’l Symp. on Healthy Aging: 60. 2016. |
| LI Z., Ma C.W., Chan Y.S. and Shum D.K.Y., Axonal trafficking of heparanase 1, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| Lam C.L.D., Chan C.H., Mak J.C.W., Freeman C., Ip M.S.M. and Shum D.K.Y., S-maltoheptaose targets syndecan-bound effectors to reduce smoking-related neutrophilic inflammation., Scientific Reports. 2015, 5: 12945. |
| Mun K.L., Tsui Y.P., Tai E.W., Chan Y.S., Shum D.K.Y. and Shea G.K.H., Rapid and efficient generation of neural progenitors from adult bone marrow stromal cells by hypoxic preconditioning, Stem Cells Research &Therapy. 2016, D16-00202. |
| Shea G.K.H., Tsui Y.P., Mung K.L., Chan Y.S. and Shum D.K.Y., Rapid and efficient generation of neural progenitors from adult bone marrow stromal cells by hypoxic preconditioning, International Society for Stem Cell Research 2016. |
| Shum D.K.Y., HAU W.F., Ma C.W. and Chan Y.S., Modulating sulfation of perineuronal chondroitins during vestibular compensatin [Seoul, Korea. Aug. 23-27, 2015], Proc. 9th InternationalConference on Proteoglycans & 10th Pan-Pacific Connective Tissue Societies Symposium. 2015. |
| Shum D.K.Y., Cai S., Han L. and Chan Y.S., Small molecule approach to direct differentiation of human induced pluripotent stem cells to sensory neurons 665.18/B44. [Chicago. Oct. 15-19, 2015], Soc. Neuroscience Abstract (USA). 2015. |
| Tam K.W., Chan Y.S. and Shum D.K.Y., Chondroitin sulphate-derived disaccharides: a potential drug for axons regrowing across the glial scar, Neuroscience Symposium 2016 & Annual Scientific Conference of The Hong Kong Society of Neurosciences: Nature and Nurture in Brain Functions. 2016. |
| Tam K.W., Chan Y.S. and Shum D.K.Y., Use of chondroitin sulphate lyases in scar treatment: kinetic considerations of macromolecular crowding, 45th IUPAC World Chemistry Congress. 2015. |
| Tam K.W., Chan Y.S. and Shum D.K.Y., Use of chondroitin sulphate lyases in scar treatment: kinetic considerations of macromolecular crowding [Busan, Korea. Aug. 9-14, 2015], Proc. 45th IUPAC World Chemistry Congress. 2015. |
| Tam K.W., Chan Y.S. and Shum D.K.Y., Use of chondroitin sulphate-derived disaccharides as a potential drug to overcome the axonal growth barrier at the glial scar [HK. March 12-13, 2016], Abstracts of 11th Int’l Symp. on Healthy Aging: Science and Aging – An Era of Discovery. 2016, 63. |
| Tam K.W., Chan Y.S. and Shum D.K.Y., Use of chondroitin sulphate-derived disaccharides as a potential drug to overcome the axonal growth barrier at the glial scar, 11st International Symposium on Healthy Aging: Science and Aging: An Era of Discovery. 2016. |
| Tsui Y.P., Tam K.W., Shum D.K.Y. and Chan Y.S., Schwann cells demonstrated lineage plasticity in culture and acquired oligodendrocyte phenotypes [HK. March 12-13, 2016] , Abstracts of 11th Int’l Symp. on Healthy Aging: Science and Aging – An Era of Discovery. 2016, 50. |
| Tsui Y.P., Tam K.W., Shum D.K.Y. and Chan Y.S., Schwann cells demonstrated lineage plasticity in culture and acquired oligodendrocyte phenotypes, Gordon Research Conference - Cellular & Molecular Neuroscience. 2016. |
| Tsui Y.P., Tam K.W., Shum D.K.Y. and Chan Y.S., Schwann cells demonstrated lineage plasticity in culture and acquired oligodendrocyte phenotypes, Neuroscience Symposium 2016 & Annual Scientific Conference of The Hong Kong Society of Neurosciences: Nature and Nurture in Brain Functions. 2016. |
| Wu L.K., Shum D.K.Y. and Chan Y.S., Astrocytic regulation of perineuronal net formation [HK. May 18, 2016], Proc. Neuroscience Symposium 2016 & Scientific Conference of The Hong Kong Society of Neurosciences. 2016, 54. |
| Researcher : Siu KL |
| List of Research Outputs |
| Lui P.Y., WONG L.Y.R., Fung C.L., Siu K.L., Yeung M.L., Yuen K.S., Chan C.P., Woo P.C.Y., Yuen K.Y. and Jin D., Middle East respiratory syndrome coronavirus M protein suppresses type I interferon expression through the inhibition of TBK1-dependent phosphorylation of IRF3, Emerging Microbes & Infections. 2016, 5: e39. |
| Researcher : So KF |
| Project Title: | Minimizing neuropsychiatric side-effects of glucocorticoid therapy by antipsychotics and Chinese medicine |
| Investigator(s): | So KF, Lee TMC, Chang RCC, Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 01/2014 |
| Completion Date: | 11/2016 |
| Project Title: | Study of gliogenesis and neurochemistry underlying psychomotor retardation induced by chronic stress and the therapeutic approach for motor training in reversing the adverse effects |
| Investigator(s): | So KF, Wu W, Lee TMC |
| Department: | Ophthalmology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2015 |
| Project Title: | Potential Role of Adiponectin Signaling in Mediating Physical Exercise-Elicited Hippocampal Neurogenesis and Antidepressive Effects in Stressed Mice |
| Investigator(s): | So KF, Xu A |
| Department: | Ophthalmology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2015 |
| List of Research Outputs |
| LAM C.S., Tipoe G.L., So K.F. and Fung M.L., Polysaccharides antagonized rat hippocampal-dependent spatial memory deficits induced by chronic intermittent hypoxia. First Exchange Camp for Biomedical Research Students in Guangdong, Hong Kong and Macau, Lycium barbarum. 2015. |
| Researcher : Song Y |
| Project Title: | A Randomized Controlled Trial of the Therapeutic Effects of Tai Chi and Mahjong on Older Persons With Cognitive Impairment |
| Investigator(s): | Song Y |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2008 |
| Project Title: | Identification of a genetic variant for heart defects (CHD) on chromosome 15 in mice |
| Investigator(s): | Song Y, Cheah KSE, Sham PC |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2012 |
| Completion Date: | 09/2015 |
| Project Title: | Investigation on Pax6 regulation of neuronal apoptosis in Alzheimer’s disease |
| Investigator(s): | Song Y |
| Department: | Biochemistry |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2013 |
| Project Title: | Study of Population Specific Linkage Disequilibrium (LD) Patterns of Human Major Histocompatibility Complex (MHC) Region for Cancers, Infectious and Autoimmunity Diseases in Southern Chinese |
| Investigator(s): | Song Y, Sham PC, Fan Y |
| Department: | Biochemistry |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2014 |
| Project Title: | The role of hnrnpa1 in human congenital heart defects |
| Investigator(s): | Song Y, Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2014 |
| Completion Date: | 10/2015 |
| Project Title: | Repurposing the approved drugs for prevention and treatment of Alzheimer’s disease in transgenic mouse models |
| Investigator(s): | Song Y, Chu LW |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Translational and Applied Research |
| Start Date: | 06/2014 |
| Completion Date: | 12/2015 |
| Project Title: | Modeling host susceptibility to influenza H7N9 virus in inbred mice: a pilot study |
| Investigator(s): | Song Y, Yeung ML, Kok KH |
| Department: | Biochemistry |
| Source(s) of Funding: | Commissioned Studies on Emerging Influenza A Viruses with Epidemic Potential |
| Start Date: | 10/2014 |
| Project Title: | Targeted sequencing to identify of genes on candidate loci causing Adolescent Idiopathic Scoliosis (AIS) |
| Investigator(s): | Song Y, Luk KDK, Chan D, Sham PC, Cheung KMC |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2015 |
| Project Title: | Study of the pathogenic mechanisms of Hnrnpa1 in congenital heart defects (CHD) |
| Investigator(s): | Song Y, Lian Q, Cheah KSE |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2016 |
| Project Title: | Investigation of the roles of HNRNPA1 in the maintenance of motor neurons |
| Investigator(s): | Song Y, Cheung MCH, Ho WL, Huen MSY |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 03/2016 |
| List of Research Outputs |
| CHENG Z., Chu H., Fan Y., Li C., Song Y., Zhou J. and Yuen K.Y., PExFInS: An Integrative Post-GWAS Explorer for Functional Indels and SNPs, Sci Rep. 2015, 5: 17302. |
| Ho J.W.Y., Yao K.M., Song Y., Chan L.K., Cook S. and Bridges S.M., Teaching Development Grant, The University Of Hong Kong. 2015. |
| LI J., Song Y., Sham P.C. and Li M., KGGSeq: a rapid and robust framework for large-scale whole genome sequencing downstream analysis with integrative functions, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| LI Y., Samartzis D., Campbell D.D., Cherny S.S., Cheung K.M.C., Luk K.D.K., Karppinen J., Song Y., Cheah K.S.E., Chan D. and Sham P.C., Two subtypes of intervertebral disc degeneration distinguished by large-scale population-based study, The Spine Journal. 2016, pii: S1529-9430(16)30095-X. |
| Plani-Lam J.H., Chow T.C., Fan Y., Garcia-Bloj B., Cheng L., Jin D., Hancock W., Fanayan S., Ingley E. and Song Y., High expression of PTPN21 in B-cell non-Hodgkin's gastric lymphoma, a positive mediator of STAT5 activity, Blood Cancer J.. 2016, 15;6:e388. |
| Shea Y.F., Chu L.W., Chan A.O., Ha J., Li Y. and Song Y., A systematic review of familial Alzheimer's disease: Differences in presentation of clinical features among three mutated genes and potential ethnic differences, J Formos Med Assoc. 2016, 115(2): 67-75. |
| XIONG C., LI Y., RAI F.M., SANDELL L., ZHANG Y., Song Y., Cheah K.S.E., Sham P.C. and Chan D., Genetic contribution to degeneration and repair potentials of the intervertebral disc in mice, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| XIONG C., LI Y., Rai F.M., Sham P.C., ZHANG Y., Song Y., Cheah K.S.E. and Chan D., Genetic contribution to intervertebral discs integrity maintenance in mouse model, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| ZHANG Z., Shea Y.F., Chu L.W. and Song Y., Circulating MicroRNAs in Plasma as Novel Biomarkers for Alzheimer’s Disease, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| Zhang Z., Li Y., Ng C.T. and Song Y., Inflammation in Alzheimer's Disease and Molecular Genetics: Recent Update, Arch Immunol Ther Exp (Warsz). 2015. |
| Researcher : Sy MH |
| Project Title: | Regulation of Microcephalin (MCPH1) by the Herpes Simplex Virus Type 1 Regulatory Protein ICP0 |
| Investigator(s): | Sy MH, Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2013 |
| Project Title: | The role of DNA Damage Response in Genomic Instability Observed in Hepatocellular Carcinoma |
| Investigator(s): | Sy MH, Ma SKY |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2015 |
| Completion Date: | 06/2016 |
| Project Title: | Genomic Integrity Conference; ATM-dependent phosphorylation of the Fanconi anemia protein PALB2 promotes the DNA Damage Response |
| Investigator(s): | Sy MH |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2015 |
| Completion Date: | 08/2015 |
| Project Title: | The role of DNA Damage and Repair Signaling in Hepatocarcinogenesis |
| Investigator(s): | Sy MH, Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 08/2015 |
| List of Research Outputs |
| GUO Y., Feng W., Sy M.H. and Huen M.S.Y., ATM-dependent Phosphorylation of the Fanconi Anemia Protein PALB2 Promotes the DNA Damage Response, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Guo Y., Feng W., Sy M.H. and Huen M.S.Y., ATM-dependent phosphorylation of the Fanconi anemia protein PALB2 promotes the DNA Damage Response, Journal of Biological Chemistry. 2015, jbc.M115.672626. |
| Researcher : Szeto YY |
| Project Title: | Transcriptional regulation of Aqp3 by Sox9 and Sox9Y440X in the mouse inner ear |
| Investigator(s): | Szeto YY, Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2012 |
| List of Research Outputs |
| Szeto Y.Y., Chu K.H., Au Y.K., Huang Y.H., Wynn S., Mak A., Chan Y.S., Lovell-Badge R., Chan W.Y., Jauch R., Fritzsch B., Sham M.H. and Cheah K.S.E., The SOX9Y440X campomelic dysplasia mutation disrupts endolymph homeostasis., Gordon Research Conference: Fibroblast Growth Factors in Development & Disease. 2016. |
| Researcher : TANG HC |
| List of Research Outputs |
| Li S.K., TANG H.C., Lau P.Y., Zhou Y. and Ching Y.P., HBx targets centrosomal protein TAX1BP2 to promote genomic instability., Cell Symposium – Human Genomics. 2015. |
| Li S.K., TANG H.C., Lau P.Y., Zhou Y. and Ching Y.P., HBx targets centrosomal protein TAX1BP2 to promote genomic instability, In: Genome Institute of Singapore, A*Star, Cell Symposium - Human Genomic, Singapore. 2015. |
| TANG H.C., The Role of Hepatitis B Virus X protein in deregulating Chromosome Stability in Hepatocellular Carcinoma (PhD Thesis), The University of Hong Kong. 2016. |
| Researcher : TANG SLM |
| List of Research Outputs |
| DIRKZWAGER R.M., Cheung Y.W., KINGHORN A.B., FRASER L.A., LIANG S., TANG S.L.M., Kotaka M., Richards J.S. and Tanner J.A., DNA aptamers for malaria diagnosis – from crystal structure to clinical application., 40th FEBS Congress 2015 “The Biochemical Basis of Life”, Berlin, Germany (2015). 2015. |
| FRASER L.A., KINGHORN A.B., TANG S.L.M., Cheung Y.W., Lim B., LIANG S., DIRKZWAGER R.M. and Tanner J.A., Oligonucleotide Functionalised Microbeads: Indispensable Tools for High-Throughput Aptamer Selection, Molecules. 2015, 20: 21298-21312. |
| Godonoga M., Lin T.Y., Oshima A., Sumitomo K., TANG S.L.M., Cheung Y.W., KINGHORN A.B., DIRKZWAGER R.M., Zhou C., Kuzuya A., Tanner J.A. and Heddle J.G., A DNA aptamer recognising a malaria protein biomarker can function as part of a DNA origami assembly, Scientific Reports. 2016, 6: 21266. |
| SHIU C.C., Cheung Y.W., DIRKZWAGER R.M., LIANG S., KINGHORN A.B., FRASER L.A., TANG S.L.M. and Tanner J.A., Aptamer-Directed DNA Tweezers, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, Chinese University of Hong Kong, Hong Kong. 2016. |
| SHIU C.C., Cheung Y.W., DIRKZWAGER R.M., LIANG S., KINGHORN A.B., FRASER L.A., TANG S.L.M. and Tanner J.A., Aptamer-mediated macromolecular recognition in facilitating DNA tweezer machinery, Aptamers in Bordeaux, Bordeaux, France. 2016. |
| SHIU C.C., Cheung Y.W., DIRKZWAGER R.M., LIANG S., KINGHORN A.B., FRASER L.A., TANG S.L.M. and Tanner J.A., Best Poster Prize: Aptamer-Directed DNA Tweezers, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, Chinese University of Hong Kong, Hong Kong 2016. 2016. |
| TANG S.L.M., Godonoga M., DIRKZWAGER R.M., KINGHORN A.B., Heddle J.G. and Tanner J.A., Aptamer-functionalized DNA origami: an emerging tool for malaria diagnosis, Hong Kong Inter-University Postgraduate Symposium on Life Science. 2016. |
| TANG S.L.M., Godonoga M., KINGHORN A.B., Cheung Y.W., Heddle J. and Tanner J.A., Aptamer-gated DNA origami nanobox for malaria detection, Aptamers in Bordeaux, Bordeaux, France. 2016. |
| TANG S.L.M., Godonoga M., KINGHORN A.B., Cheung Y.W., Heddle J. and Tanner J.A., Construction and characterization of a three-dimensional nanoscale DNA origami box functionalized by a malaria aptamer, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, Chinese University of Hong Kong, Hong Kong. 2016. |
| TANG S.L.M., Godonoga M., KINGHORN A.B., Cheung Y.W., Heddle J. and Tanner J.A., Functionalising DNA nanostructures with aptamers for molecular recognition and dynamic response, Oligo 2016 Oxford: Antisense & Therapeutic Nucleic Acids, Oxford University, United Kingdom. 2016. |
| Researcher : TANG WC |
| List of Research Outputs |
| TANG W.C., Tsang C.M., Jones G.E. and Tsao G.S.W., Tumour-associated macrophages enhance the formation of invadopodia in EBV-associated nasopharyngeal carcinoma, Gordon Research Conference. 2016. |
| Tsang C.M., TANG W.C., Jones G.E. and Tsao G.S.W., EBV infection positively modulates the TGF-beta1-induced invasiveness of nasopharyngeal epithelial cells, Gordon Research Conference. 2016. |
| Researcher : TANG X |
| List of Research Outputs |
| TANG X., CAO T., ZHU Y., ZHANG L., CHEN J., Guan X. and Huang J., A positive feedback loop between PIM2 and TNFα contributes to hepatocellular carcinoma tumorigenesis and progression, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Researcher : TONG CKB |
| List of Research Outputs |
| Hao Y., Chow A.W., Yip W.C., Li C.H., Wan T.F., TONG C.K.B., Cheung K.H., Chan W.Y., Chen Y., Cheng C.H. and Ko W.H., G protein-coupled estrogen receptor inhibits the P2Y receptor-mediated Ca2+ signaling pathway in human airway epithelia, Pflügers Archiv - European Journal of Physiology. 2016. |
| LEE S.K., TONG C.K.B., CHENG W.H., HUNG C.H. and Cheung K.H., Characterization of Two-Pore Channel 2 by Nuclear Membrane Electrophysiology, Scientific Reports. 2016, 6: 20282. |
| LEE S.K., TONG C.K.B. and Cheung K.H., Regulation of Ryanodine Receptor Type 2 Single Channel Activities by Cyclic-ADP-ribose and Calcium, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| TONG C.K.B. and Cheung K.H., Attenuation of Capacitative Calcium Entry in Familial Alzheimer’s disease by Gamma‐secretase Cleavage of Stromal Interaction Molecule 1, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| TONG C.K.B., Lai K.O. and Cheung K.H., Gamma-secretase cleaves stromal interaction molecule 1 induces capacitative calcium entry deficits in familial Alzheimer’s disease, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| TONG C.K.B., Lai K.O. and Cheung K.H., Gamma-secretase cleaves stromal interaction molecule 1 induces capacitative calcium entry deficits in familial Alzheimer’s disease, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| Researcher : Tam KW |
| List of Research Outputs |
| Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Combination of uniaxial chitosan nanofibers and immobilized chondroitinase ABC improves axonal regrowth in vitro, 11st International Symposium on Healthy Aging: Science and Aging: An Era of Discovery. 2016. |
| Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Combination of uniaxial chitosan nanofibers and immobilized chondroitinase ABS improves axonal regrowth in vitro [HK. March 12-13, 2016], Abstracts of 11th Int’l Symp. on Healthy Aging: Science and Aging – An Era of Discovery. 2016, 60. |
| Tam K.W., Chan Y.S. and Shum D.K.Y., Chondroitin sulphate-derived disaccharides: a potential drug for axons regrowing across the glial scar, Neuroscience Symposium 2016 & Annual Scientific Conference of The Hong Kong Society of Neurosciences: Nature and Nurture in Brain Functions. 2016. |
| Tam K.W., Chan Y.S. and Shum D.K.Y., Use of chondroitin sulphate lyases in scar treatment: kinetic considerations of macromolecular crowding, 45th IUPAC World Chemistry Congress. 2015. |
| Tam K.W., Chan Y.S. and Shum D.K.Y., Use of chondroitin sulphate lyases in scar treatment: kinetic considerations of macromolecular crowding [Busan, Korea. Aug. 9-14, 2015], Proc. 45th IUPAC World Chemistry Congress. 2015. |
| Tam K.W., Chan Y.S. and Shum D.K.Y., Use of chondroitin sulphate-derived disaccharides as a potential drug to overcome the axonal growth barrier at the glial scar [HK. March 12-13, 2016], Abstracts of 11th Int’l Symp. on Healthy Aging: Science and Aging – An Era of Discovery. 2016, 63. |
| Tam K.W., Chan Y.S. and Shum D.K.Y., Use of chondroitin sulphate-derived disaccharides as a potential drug to overcome the axonal growth barrier at the glial scar, 11st International Symposium on Healthy Aging: Science and Aging: An Era of Discovery. 2016. |
| Tsui Y.P., Tam K.W., Shum D.K.Y. and Chan Y.S., Schwann cells demonstrated lineage plasticity in culture and acquired oligodendrocyte phenotypes [HK. March 12-13, 2016] , Abstracts of 11th Int’l Symp. on Healthy Aging: Science and Aging – An Era of Discovery. 2016, 50. |
| Tsui Y.P., Tam K.W., Shum D.K.Y. and Chan Y.S., Schwann cells demonstrated lineage plasticity in culture and acquired oligodendrocyte phenotypes, Gordon Research Conference - Cellular & Molecular Neuroscience. 2016. |
| Tsui Y.P., Tam K.W., Shum D.K.Y. and Chan Y.S., Schwann cells demonstrated lineage plasticity in culture and acquired oligodendrocyte phenotypes, Neuroscience Symposium 2016 & Annual Scientific Conference of The Hong Kong Society of Neurosciences: Nature and Nurture in Brain Functions. 2016. |
| Researcher : Tam V |
| Project Title: | Understanding the role of clusterin in intervertebral disc degeneration |
| Investigator(s): | Tam V, Chan D |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2015 |
| List of Research Outputs |
| Tam V., Solis N., Overall C., Klein T., Cheung K.M.C., Cheah K.S.E. and Chan D., Degradome of the Intervertebral Disc, Global Spine Congress / World Forum for Spine Research. 2016. |
| Yee A., Lam P.Y., Tam V., Chan W.C.W., Chu I.K., Cheah K.S.E., Cheung K.M.C. and Chan D., Fibrotic-like changes in degenerate human intervertebral discs revealed by quantitative proteomic analysis, Osteoarthritis and Cartilage. 2016, 24: 503-513. |
| Researcher : Tan Z |
| List of Research Outputs |
| Wang C., Tan Z., Tsang K.Y., Ron D., Itoh N., Chan D. and Cheah K.S.E., The PERK pathway attenuates ER stress in hypertrophic chondrocyte via Sox9 and FGF21., Gordon Research Conference- Stress Proteins in Growth, Development & Disease, Italy, July 5-10, 2015. |
| Researcher : Tan-Un KC |
| Project Title: | King's/HKU Fellowship Awards 2010-11 |
| Investigator(s): | Tan-Un KC |
| Department: | School of Biological Sciences |
| Source(s) of Funding: | King's/HKU Fellowship Awards |
| Start Date: | 06/2010 |
| Project Title: | Zearalenone-induced toxicity in cells |
| Investigator(s): | Tan-Un KC |
| Department: | School of Biological Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2011 |
| Project Title: | Characterization of the novel distal regulatory elements of the Neuroglobin gene |
| Investigator(s): | Tan-Un KC |
| Department: | School of Biological Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 02/2012 |
| Project Title: | CHARACTERISATION OF NOVEL DISTAL REGULATORY ELEMENTS OF THE NEUROGLOBIN GENE |
| Investigator(s): | Tan-Un KC |
| Department: | School of Biological Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2013 |
| List of Research Outputs |
| Chau P.H., Ngai H.H.Y., Leung Y.M.A., Li S.F., Yeung L.O.Y. and Tan-Un K.C., Preference of food saltiness and willingness to consume low-sodium content food in a Chinese population, The Journal of Nutrition, Health & Aging. 2016. |
| Researcher : Tang F |
| List of Research Outputs |
| Li R.H.W., Liao S., Chiu C.N., Yeung W.S.B., Ng E.H.Y., Cheung A.N.Y., Tang F. and O W.S., Effects of adrenomedullin on the expression of inflammatory cytokines and chemokines in oviducts from women with tubal ectopic pregnancy: an in-vitro experimental study, Reproductive Biology and Endocrinology. 2015, 13. |
| Researcher : Tang HMV |
| List of Research Outputs |
| CHENG Y., GAO W., Tang H.M.V., Deng J., Wong C.M., Chan C.P. and Jin D., β-TrCP-mediated ubiquitination and degradation of liver-enriched transcription factor CREB-H, Scientific Reports. 2016, 6. |
| CHENG Y., GAO W., Tang H.M.V., Deng J., Chan C.P. and Jin D., β-TrCP-mediated ubiquitination and degradation of liver-enriched transcription, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| GAO W., Tang H.M.V., CHENG Y., Deng J., Chan C.P. and Jin D., Ubiquitination and degradation of CRTC1 transcriptional coactivator triggered by salt-inducible kinase 1-dependent phosphorylation, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Siu C.W.K., Lam C.W., Gao W., Tang H.M.V., Jin D. and Mak C.M., Unmasking a novel disease gene NEO1 associated with autism spectrum disorders by a hemizygous deletion on chromosome 15 and a functional polymorphism, Behavioural Brain Research. 2016, 300: 135-142. |
| YUEN C.K., Chan C.P., FUNG S.Y., WANG P., Wong L.W.M., Tang H.M.V., Yuen K.S., Chan C.P., Jin D. and Kok K.H., Suppression of Type I Interferon Production by Human T-Cell Leukemia Virus Type 1 Oncoprotein Tax through Inhibition of IRF3 Phosphorylation, Journal of Virology. 2016, 90: 3902-3912. |
| Researcher : Tanner JA |
| Project Title: | Comparative Characterization of the Two Polyphosphate Kinases of M. tuberculosis |
| Investigator(s): | Tanner JA |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 02/2005 |
| Project Title: | Defining the Roles of the Fundamental Macromolecule Inorganic Polyphosphate in Osteoblasts |
| Investigator(s): | Tanner JA, Watt RM |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2013 |
| Project Title: | 3-D Printed Aptamer-Enabled Diagnostic Dominoes for Malaria |
| Investigator(s): | Tanner JA |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Project Title: | Aptamer-mediated detection of luteinizing hormone pulsatility – a transformational approach towards managing infertility |
| Investigator(s): | Tanner JA |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2014 |
| Project Title: | Aptamer-mediated Point-of-Care Diagnostics (CRF) |
| Investigator(s): | Tanner JA |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding for Incubating Group-based Collaborative Research Projects |
| Start Date: | 01/2015 |
| Project Title: | DNA origami interfaced with aptamer-mediated molecular recognition for integrated modular diagnostics |
| Investigator(s): | Tanner JA, Watt RM |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Tetrapod Palindromic Capture Aptamers for Diagnostic Devices |
| Investigator(s): | Tanner JA |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Translational and Applied Research |
| Start Date: | 06/2015 |
| Project Title: | FEBS 2015; DNA aptamers for malaria diagnosis - from crystal structure to clinical application/Long-Chain inorganic polyphosphate is highly enriched in osteoblastic matrix vesicles /Developing scientific writing and integrating feedback for undergraduate biomedical students through mimicking the professional journal article review process |
| Investigator(s): | Tanner JA |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2015 |
| Completion Date: | 07/2015 |
| Project Title: | DNA Display SELEX ??a new approach to evolve fluorescent tools to image RNA in living cells |
| Investigator(s): | Tanner JA, Shum HC |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2016 |
| List of Research Outputs |
| Cheung Y.W., DIRKZWAGER R.M., Cardoso J., Wong A.W.C. and Tanner J.A., An aptamer-based diagnostic test specific for Falciparum malaria, Aptamers in Bordeaux, Bordeaux, France. 2016. |
| DIRKZWAGER R.M., FRASER L.A., LIANG S., Cheung Y.W., KINGHORN A.B., Richards J.S. and Tanner J.A., DNA aptamers as antibody surrogates for molecular recognition in rapid diagnostic tests for malaria, Molecular Approaches to Malaria, Lorne, Australia. 2016. |
| DIRKZWAGER R.M., Cheung Y.W., KINGHORN A.B., FRASER L.A., LIANG S., TANG S.L.M., Kotaka M., Richards J.S. and Tanner J.A., DNA aptamers for malaria diagnosis – from crystal structure to clinical application., 40th FEBS Congress 2015 “The Biochemical Basis of Life”, Berlin, Germany (2015). 2015. |
| DIRKZWAGER R.M., LIANG S. and Tanner J.A., Development of Aptamer-Based Point-of-Care Diagnostic Devices for Malaria Using Three-Dimensional Printing Rapid Prototyping, ACS Sensors. 2016, 1: 420-426. |
| FRASER L.A., DIRKZWAGER R.M., LIANG S., Cheung Y.W., KINGHORN A.B., Lim B. and Tanner J.A., 3D printing aptamer based rapid diagnostic tests for the point of care diagnosis of malaria, Malaria in Melbourne (MiM), Monash University, Melbourne, Australia. 2015. |
| FRASER L.A., KINGHORN A.B., TANG S.L.M., Cheung Y.W., Lim B., LIANG S., DIRKZWAGER R.M. and Tanner J.A., Oligonucleotide Functionalised Microbeads: Indispensable Tools for High-Throughput Aptamer Selection, Molecules. 2015, 20: 21298-21312. |
| Godonoga M., Lin T.Y., Oshima A., Sumitomo K., TANG S.L.M., Cheung Y.W., KINGHORN A.B., DIRKZWAGER R.M., Zhou C., Kuzuya A., Tanner J.A. and Heddle J.G., A DNA aptamer recognising a malaria protein biomarker can function as part of a DNA origami assembly, Scientific Reports. 2016, 6: 21266. |
| KHONG M.L., Li L., LU B., Watt R.M. and Tanner J.A., Determining proteins that specifically bind to polyphosphate in osteoblasts, Inorganic polyphosphate (polyP) physiology. Biochemical Society Hot Topic Event, London, UK. 2015. |
| KHONG M.L. and Tanner J.A., Elucidating the Functional Implications of Polyphosphate-Protein Interactions, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| KHONG M.L., Li L. and Tanner J.A., Elucidating the Functional Implications of Polyphosphate-protein Interactions, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, Chinese University of Hong Kong, Hong Kong. 2016. |
| LIANG S., Dhillo W., Cass A.E.G. and Tanner J.A., Development of aptamer-based electrochemical sensing system for monitoring luteinizing hormone pulsatility, Aptamers in Bordeaux, Bordeaux, France. 2016. |
| LIANG S., DIRKZWAGER R.M. and Tanner J.A., Rapid prototyping aptamer-enabled malaria diagnostics using three-dimensional printing, Aptamers 2016, 3rd Oxford Symposium on Aptamers, Oxford University, United Kingdom. 2016. |
| Li L., KHONG M.L., Lu B., Buchet R., Watt R.M. and Tanner J.A., Long-chain inorganic polyphosphate is highly enriched in osteoblastic matrix vesicles., 40th FEBS Congress 2015 “The Biochemical Basis of Life”, Berlin, Germany (2015).. 2015. |
| Li L., KHONG M.L., Mebarek R., Buchet R. and Tanner J.A., Long-chain polyphosphate is enriched in mineralized osteoblasts and matrix vesicles, Inorganic polyphosphate (polyP) physiology, Biochemistry Society Hot Topic Event, London, UK. 2015. |
| SHIU C.C., Cheung Y.W., DIRKZWAGER R.M., LIANG S., KINGHORN A.B., FRASER L.A., TANG S.L.M. and Tanner J.A., Aptamer-Directed DNA Tweezers, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, Chinese University of Hong Kong, Hong Kong. 2016. |
| SHIU C.C., Cheung Y.W., DIRKZWAGER R.M., LIANG S., KINGHORN A.B., FRASER L.A., TANG S.L.M. and Tanner J.A., Aptamer-mediated macromolecular recognition in facilitating DNA tweezer machinery, Aptamers in Bordeaux, Bordeaux, France. 2016. |
| SHIU C.C., Cheung Y.W., DIRKZWAGER R.M., LIANG S., KINGHORN A.B., FRASER L.A., TANG S.L.M. and Tanner J.A., Best Poster Prize: Aptamer-Directed DNA Tweezers, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, Chinese University of Hong Kong, Hong Kong 2016. 2016. |
| Schmidt C., Schroder C., Tanner J.A., KINGHORN A.B., Schierack P. and Rodiger S.A., A multiplex high-throughput screening platform for investigation of buffer-binding conditions for aptamers., Potsdam Days on Bioanalysis, Berlin, Germany. 2015. |
| TANG S.L.M., Godonoga M., DIRKZWAGER R.M., KINGHORN A.B., Heddle J.G. and Tanner J.A., Aptamer-functionalized DNA origami: an emerging tool for malaria diagnosis, Hong Kong Inter-University Postgraduate Symposium on Life Science. 2016. |
| TANG S.L.M., Godonoga M., KINGHORN A.B., Cheung Y.W., Heddle J. and Tanner J.A., Aptamer-gated DNA origami nanobox for malaria detection, Aptamers in Bordeaux, Bordeaux, France. 2016. |
| TANG S.L.M., Godonoga M., KINGHORN A.B., Cheung Y.W., Heddle J. and Tanner J.A., Construction and characterization of a three-dimensional nanoscale DNA origami box functionalized by a malaria aptamer, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, Chinese University of Hong Kong, Hong Kong. 2016. |
| TANG S.L.M., Godonoga M., KINGHORN A.B., Cheung Y.W., Heddle J. and Tanner J.A., Functionalising DNA nanostructures with aptamers for molecular recognition and dynamic response, Oligo 2016 Oxford: Antisense & Therapeutic Nucleic Acids, Oxford University, United Kingdom. 2016. |
| Tanner J.A., Aptamer-enabled diagnostics for malaria, The 1st Peking University-Hong Kong University Joint Symposium on Chemical Biology, Hong Kong. 2016. |
| Tanner J.A., Aptasensors for point-of-care malaria diagnosis, Biosensors 2016, Gothenburg, Sweden. 2016. |
| Tanner J.A., Developing scientific writing and integrating feedback for undergraduate biomedical students through mimicking the professional journal article review process. Best poster in education prize, 40th FEBS Congress 2015 “The Biochemical Basis of Life”, Berlin, Germany. 2015. |
| Tanner J.A., Developing scientific writing and integrating feedback for undergraduate biomedical students through mimicking the professional journal article review process., 40th FEBS Congress 2015 “The Biochemical Basis of Life”, Berlin, Germany (2015).. 2015. |
| Tanner J.A., Learning through collaborative writing and refereeing: mimicking the professional journal review process in an undergraduate biomedical sciences course, Frontiers in Medical and Health Sciences Education, Hong Kong. 2015. |
| Tanner J.A., Nucleic acid aptamers as versatile tools for biosensing, diagnostics and nanotechnology: from evolution to application, Sadler’s Symposium on Metals in Life Processes, Sun Yat Sen University, Guangzhou, China (Keynote lecture). 2015. |
| Tanner J.A., Nucleic acid aptamers for molecular recognition in diagnostic systems: malaria diagnosis as a proof of concept, The 8th International Symposium on Microchemistry and Microsystems (ISMM2016), Hong Kong. 2016. |
| Tanner J.A., Progress in aptamer-mediated malaria diagnosis, Aptamers 2016, 3rd Oxford Symposium on Aptamers, Oxford University, United Kingdom. 2016. |
| Tanner J.A., The University of Hong Kong Teaching Excellence Awards 2015: Outstanding Teacher Award, The University of Hong Kong. 2016. |
| Researcher : Tipoe GL |
| Project Title: | 23rd Conference of the Asian Pacific Association for the Study of the Liver (APASL); Polysaccharides from Lycium barbarum attenuates hepatic steatosis, fibrosis and inflammation in non-alcoholic liver diseases (NAFLD) rat model |
| Investigator(s): | Tipoe GL |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2013 |
| Project Title: | Multifunctional M30 drug down-regulates carbon tetrachloride (CCl4) – induced hepatic oxidative stress, inflammation and apoptosis in vitro and in vivo models |
| Investigator(s): | Tipoe GL |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2014 |
| Completion Date: | 04/2016 |
| Project Title: | The regulation of cylcooxygenase-1 in a carbon tetrachloride induced acute liver injury animal model |
| Investigator(s): | Tipoe GL |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 04/2015 |
| Project Title: | Therapeutic effects of Wolfberry (Lycium barbarum polysaccharides; LBP) in non-alcoholic fatty liver disease (NAFLD) animal models |
| Investigator(s): | Tipoe GL, So KF |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2015 |
| Project Title: | Novel anti-hepatic cancer properties of garlic-derived SAMC through direct targeting of LRP6/Wnt signaling pathway |
| Investigator(s): | Tipoe GL |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2016 |
| List of Research Outputs |
| Dong C.F., Xiao J., Shan L.B., Li H.Y., Xiong Y.J., Yang G.L., Liu J., Yao S.M., Li S.X., Le X.H., Yuan J., Zhou B.P., Tipoe G.L. and Liu Y.X., Combined acoustic radiation force impulse, aminotransferase to platelet ratio index and Forns index assessment for hepatic fibrosis grading in hepatitis B, World Journal of Hepatology. 2016, 8: 616. |
| LAM C.S., Lee M.K.Y., Mak J.C.W., Fung A.C.H., Tipoe G.L. and Fung M.L., Chronic intermittent hypoxia exacerbates depressive-like behaviors in high fat diet-fed mice. The 19th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, Journal of the Hong Kong College of Cardiology. 2015, 23(2): 97, CP5. |
| LAM C.S., LI J., LIU Y.Y., Tipoe G.L. and Fung M.L., Maladaptive up-regulation of brain monoamine oxidase-A contributes to depressive-like behavior in a rat model of obstructive sleep apnea, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| LAM C.S., LI J., Tipoe G.L. and Fung M.L., Maladaptive up-regulation of brain monoamine oxidase-A contributes to depressive-like behaviors in a rat model of obstructive sleep apnea, 20th Research Postgraduate Symposium, HKU. 2015, P3.3. |
| LAM C.S., Lee M.K.Y., Mak J.C.W., Ip M.S.M., Fung A.C.H., Tipoe G.L. and Fung M.L., Mechanistic roles of monoamine oxidase A in the exacerbative effect of chronic intermittent hypoxia on the depressive-like behavior in the mice model of diet-induced obesity. The Eleventh Eleventh International Symposium on Healthy Aging – Science and Aging, An Era of Discovery, OP3. 2016. |
| LAM C.S., Tipoe G.L., Wong K.C., Youdim M.B.H. and Fung M.L., Multifunctional drug M30 mitigates neurodegeneration and depressive-like behaviors induced by corticosterone in rats. Hong Kong Inter-University Postgraduate Symposium, Biochemical Sciences. 2016. |
| LAM C.S., Tipoe G.L., Wong K.C., Youdim M.B.H. and Fung M.L., Multifunctional drug M30 mitigates neurodegeneration and depressive-like behaviors induced by corticosterone in rats, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| LAM C.S., Tipoe G.L., So K.F. and Fung M.L., Polysaccharides antagonized rat hippocampal-dependent spatial memory deficits induced by chronic intermittent hypoxia. First Exchange Camp for Biomedical Research Students in Guangdong, Hong Kong and Macau, Lycium barbarum. 2015. |
| LI J., LAM C.S., Tipoe G.L. and Fung M.L., Increased MAO-A Expression Mediated by Norepinephrine Plays a Role in Intermittent Hypoxia-induced Oxidative Stress and Cell Death in SH-SY5Y Cells, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| LI J., LAM C.S., Tipoe G.L. and Fung M.L., Increased MAO-A expression mediated by norepinephrine plays a role in intermittent hypoxia-induced oxidative stress and cell death in SH-SY5Y cells, 20th Research Postgraduate Symposium, HKU. 2015, P3.06. |
| LI J., LAM C.S., Tipoe G.L. and Fung M.L., Norepinephrine increases the monoamine oxidase-A and oxidative stress in SH-SY5Y cells. The 19th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, Journal of the Hong Kong College of Cardiology. 2015, 23(2): 95, CP1. |
| LI J., LAM C.S., Tipoe G.L. and Fung M.L., Upregulated biosynthesis of Norepinephrine and MAOA expression mediates the oxidative stress and cell death in SH-SY5Y cells, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| LI J., LAM C.S., Tipoe G.L. and Fung M.L., Upregulated biosynthesis of norepinephrine and MAOA expression mediates the oxidative stress and cell death in SH-SY5Y cells. The Eleventh International Symposium on Healthy Aging, Science and Aging: An Era of Discovery. 2016, P47. |
| WANG H., Sit W.H., Tipoe G.L., Liu Z.G. and Wan J.M.F., Comparative proteomic analysis of fibrotic liver of rats fed high fat diet contained lard versus corn oil, Clinical Nutrition. 2015. |
| XIAO J., Liu Y.X., Xing F.Y., Leung T.M., Liong E.C. and Tipoe G.L., Bee’s honey attenuates non-alcoholic steatohepatitis-induced hepatic injury through the regulation of thioredoxin-interacting protein–NLRP3 inflammasome pathway, European Journal of Nutrition. 2016, 55: 1465-1477. |
| Xiao J. and Tipoe G.L., Inflammasomes in non-alcoholic fatty liver disease, Frontiers in Bioscience. 2016, 21: 683-695. |
| Zhang H.U.I.N.A., Liu J., Qu D., Wang L., Luo J.Y., Lau C.W., Liu P.S., Gao Z., Tipoe G.L., Lee H.K., Ng C.F., Ma R.C.W., Yao X.Q. and Huang Y., Inhibition of miR-200c Restores Endothelial Function in Diabetic Mice Through Suppression of COX-2, Diabetes. 2016, 65: 1196-1207. |
| Researcher : Tong M |
| Project Title: | The clinical and functional significances of glucose transporter, isoform 3 (GLUT3) in CD133+ liver cancer stem cells driven Hepatocellular carcinoma |
| Investigator(s): | Tong M, Ma SKY |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2015 |
| Completion Date: | 08/2016 |
| List of Research Outputs |
| Tong M. and Ma S.K.Y., ANXA3/JNK Signaling Promotes Self-Renewal and Tumor Growth, and Its Blockade Provides a Therapeutic Target for Hepatocellular Carcinoma, Shanghai Joint Forum 2015. 兩地三方學術會議 2015. |
| Researcher : Tsang CM |
| Project Title: | The biological significance of TGF-β1 in sensitizing the nasopharyngeal epithelial cells to EBV infection |
| Investigator(s): | Tsang CM, Yip YL, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2013 |
| Completion Date: | 04/2016 |
| Project Title: | The protective role of Epstein-Barr virus infection towards starvation-induced apoptosis |
| Investigator(s): | Tsang CM, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2014 |
| Project Title: | Potentiation of tumor-associated macrophages (TAMs)-induced invasiveness in EBV-associated nasopharyngeal epithelial cells |
| Investigator(s): | Tsang CM, Tsao GSW |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 07/2015 |
| List of Research Outputs |
| Jia L.J., Tsang C.M., Yip Y.L., Law W., ZHANG J., Deng W. and Tsao G.S.W., Establishment and characterization of immortalized nasopharyngeal epithelial cells with stable infection of Epstein-Barr virus, Gordon Research Conference - Nasopharyngeal Carcinoma. 2016. |
| TANG W.C., Tsang C.M., Jones G.E. and Tsao G.S.W., Tumour-associated macrophages enhance the formation of invadopodia in EBV-associated nasopharyngeal carcinoma, Gordon Research Conference. 2016. |
| Tsang C.M., TANG W.C., Jones G.E. and Tsao G.S.W., EBV infection positively modulates the TGF-beta1-induced invasiveness of nasopharyngeal epithelial cells, Gordon Research Conference. 2016. |
| ZHANG J., Jia L.J., LIN W., Yip Y.L., Tsang C.M., Zhou Y., Zhu D., Deng W. and Tsao G.S.W., Significance of Epstein-Barr virus encoded Latent Membrane Protein 1-Induced mTOR Signaling in Nasopharyngeal Cells, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| ZHU D., ZHANG J., Deng W., Yip Y.L., Lung H.L., Tsang C.M., Law W.T., Yang J., Lau M.Y., Lung M.L., Cheung A. and Tsao G.S.W., Significance of NF-kB activation in immortalization of nasopharyngeal epithelial cells., Int. J. Cancer. 2015. |
| Researcher : Tsang KY |
| Project Title: | Stress Proteins in Growth, Development & Disease Gordon Research Conference; Pathological ER stress impairs osteocyte maturation causing hyperostosis in mice |
| Investigator(s): | Tsang KY |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2015 |
| Completion Date: | 07/2015 |
| List of Research Outputs |
| CHU T.L., Tsang K.Y., Zhou Z. and Cheah K.S.E., The role of MMP14 in lineage progression of hypertrophic chondrocytes, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| GUO S., Tsang K.Y., Au Y.K., Tam W.K., Leung V.Y.L. and Cheah K.S.E., Generation of a Chordoma Cell Line: a Model of Human Notochordal Cells?, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Tsang K.Y., Wu M.H., Zhang M., Gu J., Yu X. and Chan D., Dissecting the transition from hypertrophic chondrocyte to osteoblast in skeletal development and growth, Gordon Research Conference on Bones & Teeth, Galveston, TX, USA, February 14-19, 2016. |
| Tsang K.Y., Wu M.H., Zhang M., Gu J., Yu X., Chan D. and Cheah K.S.E., Dissecting the transition from hypertrophic chondrocyte to osteoblast in skeletal development and growth, Gordon Research Conference – Bones & Teeth, Galveston, TX, USA, February 14-19, 2016. |
| Tsang K.Y., Chan W.C.W., Cheng Y.W., Chik H., Boot-Handford R.P., Boyde, A.J.S., Cheung K.M.C. and Cheah K.S.E., Chan D., Pathological ER stress impairs osteocyte maturation causing hyperostosis in mice., Gordon Research Conference- Stress Proteins in Growth, Development & Disease, Italy, July 5-10, 2015. |
| Tsang K.Y., Chan W.C.W., Cheng Y.W., Chik H., Boot-Handford R.P., Boyde A., Jones S.H.E.I.L.A., Cheung K.M.C., Cheah K.S.E. and Chan D., Pathological ER stress impairs osteocyte maturation causing hyperostosis in mice, Gordon Research Conference on Stress Proteins in Growth, Development & Disease. 2015. |
| Tsang K.Y., Li X., Gu J., Chan D., Zhang M.Q. and Cheah K.S.E., Reconstructing the chondro-osteoblastic lineage by single cell RNA-seq, Single Cell Biology, 8-10 March 2016, Wellcome Genome Campus, Hinxton, Cambridge, UK. 2016. |
| Tsang K.Y., Chan D. and Cheah K.S.E., Wiley Blackwell Prize 2016, In: Harukazu Nakamura, Development, Growth & Differentiation, John Wiley & Sons, Inc.. 2016. |
| Wang C., Tan Z., Tsang K.Y., Ron D., Itoh N., Chan D. and Cheah K.S.E., The PERK pathway attenuates ER stress in hypertrophic chondrocyte via Sox9 and FGF21., Gordon Research Conference- Stress Proteins in Growth, Development & Disease, Italy, July 5-10, 2015. |
| Researcher : Tsang SL |
| List of Research Outputs |
| WANG L., ZHANG H., Wong Y.M.E., Tsang S.L., Lendahl U. and Sham M.H., Notch signaling regulates pharyngeal ectoderm development, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Researcher : Tsao GSW |
| Project Title: | The role of TGF-beta in EBV infection and pathogenesis of nasopharyngeal carcinoma |
| Investigator(s): | Tsao GSW, Lan HY |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2009 |
| Project Title: | Systematic Development of Molecular Targets for Nasopharyngeal Carcinoma |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Theme-based Research Scheme |
| Start Date: | 01/2014 |
| Project Title: | Dynamics of EBV episome maintenance in infected nasopharyngeal epithelial cells |
| Investigator(s): | Tsao GSW, Chen H, Deng W |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Project Title: | Live cell imaging of invasion by EBV-infected nasopharyngeal epithelial cells. |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2014 |
| Completion Date: | 06/2016 |
| Project Title: | Regulation of invadopodia formation by the EBV-encoded LMP1 in nasopharyngeal epithelial cells |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Delineating the signal pathways of LMP1 in the activation of mTOR signaling in nasopharyngeal carcinoma cells |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2015 |
| Project Title: | Establishment of a shared live cell imaging platform for super-resolution microscopy |
| Investigator(s): | Tsao GSW, Bruzzone R, Chang RCC, Cheung MCH, Ching YP, Fu C, Huen MSY, Jin D, Yang D, Yu C, Yuen KWY |
| Department: | Anatomy |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Major Equipment Project |
| Start Date: | 06/2015 |
| Project Title: | Advanced Imaging - From System Biology to Single Cell & Single Molecule Analysis |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Croucher Summer Courses |
| Start Date: | 07/2015 |
| Project Title: | Annul meeting 2016 of the American Association for Cancer Research; "Establishment and characterization of xenografts and cell lines trom nasopharyngeal carcinoma" |
| Investigator(s): | Tsao GSW |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2016 |
| Completion Date: | 04/2016 |
| Project Title: | Biomimetic 3D Microsystem to Study Tumour Survival and Drug Responses |
| Investigator(s): | Tsao GSW |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 06/2016 |
| List of Research Outputs |
| Chen H., Lee L., Li G., Tsao G.S.W. and Chiu J., Upregulation of glycolysis and oxidative phosphorylation in benzo[α]pyrene and arsenic-induced rat lung epithelial transformed cells, Oncotarget. 2016. |
| Deng W., Cheung S.T., Tsao G.S.W., Wang X.M.A. and Tiwari A.F.Y., Telomerase activity and its association with psychological stress, mental disorders, lifestyle factors and interventions: A systematic review, Psychoneuroendocrinology. 2016, 64: 150-163. |
| FUNG S.W., CHEUNG P.F.Y., YIP C.W., NG W.C., Tsao G.S.W. and CHEUNG S.T., Expression of ATP-binding cassette (ABC) transporter ABCF1 in fetal liver and liver cancer associated with cancer stem cell markers GEP, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| HONG M., LI S., TAN H.Y., Wang N., Tsao G.S.W. and Feng Y., Current Status of Herbal Medicines in Chronic Liver Disease Therapy: The Biological Effects, Molecular Targets and Future Prospects, International Journal of Molecular Sciences. 2015, 16: 28705-28745. |
| Jia L.J., Tsang C.M., Yip Y.L., Law W., ZHANG J., Deng W. and Tsao G.S.W., Establishment and characterization of immortalized nasopharyngeal epithelial cells with stable infection of Epstein-Barr virus, Gordon Research Conference - Nasopharyngeal Carcinoma. 2016. |
| LIN W., Yip Y.L., LO K.W., Deng W. and Tsao G.S.W., Establishment of a new cell line of nasopharyngeal carcinoma, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Lam C.L.D., Luo Y., Fu K.H., Lui M.M.S., Chan K.H., Wistuba I.I., Gao B., Tsao G.S.W., Ip M.S.M. and Minna J.D., Nicotinic acetylcholine receptor expression in human airway correlates with lung function, American Journal of Physiology - Lung Cellular and Molecular Physiology. 2016, 310: L232-L239. |
| Li B., XU W., Guan X., Qin Y...R..., Law S.Y.K., Lee N.P.Y., Chan K.T., Tam P.Y., Li Y.Y., Chan K.W., Yuen H...F..., Tsao G.S.W., He Q...Y... and Cheung A., Competitive Binding Between Id1 and E2F1 to Cdc20 Regulates E2F1 Degradation and Thymidylate Synthase Expression to Promote Esophageal Cancer Chemoresistance, Clinical Cancer Research. 2016, 22: 1243-1255. |
| Li J., Li B., XU W., Chan K.W., Guan X., Qin Y.R., Lee N.P.Y., Chan K.T., Law S.Y.K., Tsao G.S.W. and Cheung A., Role of AMPK signaling in mediating the anticancer effects of silibinin in esophageal squamous cell carcinoma, Expert Opinion on Therapeutic Targets. 2016, 20: 7-18. |
| Su H., Tiwari A.F.Y., Ngan H.Y.S., Yip Y.L., Cheung A., Tsao G.S.W. and Deng W., Extremely stringent activation of p16INK4a prevents immortalization of uterine cervical epithelial cells without human papillomavirus oncogene expression, Oncotarget. 2016. |
| TAN H.Y., Wang N., Man K., Tsao G.S.W., Che C.M. and Feng Y., Autophagy-induced RelB/p52 activation mediates tumour-associated macrophage repolarisation and suppression of hepatocellular carcinoma by natural compound baicalin, Cell Death and Disease. 2015, 6: e1942. |
| TAN H.Y., Wang N., Tsao G.S.W., Che C.M., Yuen R.M.F. and Feng Y., IRE1α inhibition by natural compound genipin on tumour associated macrophages reduces growth of hepatocellular carcinoma, Oncotarget. 2016. |
| TANG W.C., Tsang C.M., Jones G.E. and Tsao G.S.W., Tumour-associated macrophages enhance the formation of invadopodia in EBV-associated nasopharyngeal carcinoma, Gordon Research Conference. 2016. |
| Tsang C.M., TANG W.C., Jones G.E. and Tsao G.S.W., EBV infection positively modulates the TGF-beta1-induced invasiveness of nasopharyngeal epithelial cells, Gordon Research Conference. 2016. |
| Xiong D., Du Y.L., Wang H.B., Zhao B., Zhang H.L., Li Y., Hu L.J., Cao J.Y., Zhong Q., Liu W.L., Li M.Z., Zhu X.F., Tsao G.S.W., Hutt-Fletcher L.M., Song E., Zeng Y.X., Kieff E. and Zeng M.S., Nonmuscle myosin heavy chain IIA mediates Epstein-Barr virus infection of nasopharyngeal epithelial cells., Proc Natl Acad Sci USA. 2015, 112: 11036-41. |
| Yuen K.S., Chan C.P., Wong N.H.M., HO C.H., HO T.H., Deng W., Tsao G.S.W., Chen H., Kok K.H. and Jin D., Targeted genome editing of Epstein-Barr virus by CRISPR/Cas9 technology in human cells, 34th Annual Meeting of the American Society for Virology (ASV2015). 2015. |
| ZHANG J., Lau M.Y., ZHU D. and Tsao G.S.W., Functional Study of Epstein-Barr virus Encoded Latent Membrane Protein 1 (LMP1)-Induced mTOR Activation in Nasopharyngeal Carcinoma Cell, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| ZHANG J., Jia L.J., LIN W., Yip Y.L., Tsang C.M., Zhou Y., Zhu D., Deng W. and Tsao G.S.W., Significance of Epstein-Barr virus encoded Latent Membrane Protein 1-Induced mTOR Signaling in Nasopharyngeal Cells, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| ZHU D., ZHANG J., Deng W., Yip Y.L., Lung H.L., Tsang C.M., Law W.T., Yang J., Lau M.Y., Lung M.L., Cheung A. and Tsao G.S.W., Significance of NF-kB activation in immortalization of nasopharyngeal epithelial cells., Int. J. Cancer. 2015. |
| Researcher : Tse G |
| List of Research Outputs |
| Tse G., Tse V., Yeo J.M. and Sun B., Atrial Anti-Arrhythmic Effects of Heptanol in Langendorff-Perfused Mouse Hearts, PLOS ONE. 2016, 11: e0148858. |
| Tse G., Sollei T., Ali S.M. and Kukreja N., Caecal herniation through the foramen of Winslow, BJR|case reports. 2016, 20150330. |
| Tse G., Wong S.T., Tse V., Lee Y.T., Lin H.Y. and Yeo J.M., Cardiac dynamics: Alternans and arrhythmogenesis, Journal of Arrhythmia. 2016. |
| Tse G. and Yeo J.M., Conduction abnormalities and ventricular arrhythmogenesis: The roles of sodium channels and gap junctions, IJC Heart & Vasculature. 2015, 9: 75-82. |
| Tse G., Croucher Foundation Clinical Assistant Professorship, The Croucher Foundation, Hong Kong. 2016. |
| Tse G., Wong S.T., Tse V. and Yeo J.M., Depolarization vs. repolarization: what is the mechanism of ventricular arrhythmogenesis underlying sodium channel haploinsufficiency in mouse hearts?, Acta Physiologica. 2016. |
| Tse G., Lai E.T., Yeo J.M. and Yan B.P., Electrophysiological Mechanisms of Bayés Syndrome: Insights from Clinical and Mouse Studies, Frontiers in Physiology. 2016, 7. |
| Tse G., Lai E.T., Lee A.P., Yan B.P. and Wong S.H., Electrophysiological Mechanisms of Gastrointestinal Arrhythmogenesis: Lessons from the Heart, Frontiers in Physiology. 2016, 7. |
| Tse G., Lai E.T., Yeo J.M., Tse V. and Wong S.H., Mechanisms of Electrical Activation and Conduction in the Gastrointestinal System: Lessons from Cardiac Electrophysiology, Frontiers in Physiology. 2016, 7. |
| Tse G., Mechanisms of cardiac arrhythmias, Journal of Arrhythmia. 2015. |
| Tse G., Wong S.T., Tse V. and Yeo J.M., Monophasic action potential recordings: which is the recording electrode?, Journal of Basic and Clinical Physiology and Pharmacology. 2016, 0. |
| Tse G., Wong S.T., Tse V. and Yeo J.M., Restitution analysis of alternans using dynamic pacing and its comparison with S1S2 restitution in heptanol-treated, hypokalaemic Langendorff-perfused mouse hearts, Biomedical Reports. 2016. |
| Tse G., Tse V. and Yeo J.M., Ventricular anti-arrhythmic effects of heptanol in hypokalaemic, Langendorff-perfused mouse hearts, Biomedical Reports. 2016. |
| Researcher : Tsui YP |
| Project Title: | Axonal regulation of peripheral nervous system glia identity |
| Investigator(s): | Tsui YP, Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2015 |
| Completion Date: | 08/2016 |
| Project Title: | International Society for Stem Cell Research Annual Meeting 2016; Cultured Schwann cells demonstrated lineage plasticity and acquired oligodendrocyte phenotypes |
| Investigator(s): | Tsui YP |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2016 |
| Completion Date: | 06/2016 |
| List of Research Outputs |
| Mun K.L., Tsui Y.P., Tai E.W., Chan Y.S., Shum D.K.Y. and Shea G.K.H., Rapid and efficient generation of neural progenitors from adult bone marrow stromal cells by hypoxic preconditioning, Stem Cells Research &Therapy. 2016, D16-00202. |
| Mung K.L., Tsui Y.P., Tai W.Y.E. and Shea G.K.H., Hypoxia enhances neurosphere formation in bone marrow stromal cells via epidermal growth factor receptor signaling , The 36th Annual Congress of the HKOA. 2015. |
| Shea G.K.H., Tsui Y.P., Mung K.L., Chan Y.S. and Shum D.K.Y., Rapid and efficient generation of neural progenitors from adult bone marrow stromal cells by hypoxic preconditioning, International Society for Stem Cell Research 2016. |
| Tsui Y.P., Tam K.W., Shum D.K.Y. and Chan Y.S., Schwann cells demonstrated lineage plasticity in culture and acquired oligodendrocyte phenotypes [HK. March 12-13, 2016] , Abstracts of 11th Int’l Symp. on Healthy Aging: Science and Aging – An Era of Discovery. 2016, 50. |
| Tsui Y.P., Tam K.W., Shum D.K.Y. and Chan Y.S., Schwann cells demonstrated lineage plasticity in culture and acquired oligodendrocyte phenotypes, Gordon Research Conference - Cellular & Molecular Neuroscience. 2016. |
| Tsui Y.P., Tam K.W., Shum D.K.Y. and Chan Y.S., Schwann cells demonstrated lineage plasticity in culture and acquired oligodendrocyte phenotypes, Neuroscience Symposium 2016 & Annual Scientific Conference of The Hong Kong Society of Neurosciences: Nature and Nurture in Brain Functions. 2016. |
| Researcher : VIRWANI PD |
| List of Research Outputs |
| VIRWANI P.D., Zhou L., Wang Y. and Chung S.K., Role of Exchange Protein Directly Activated by cAMP 1 & 2 (Epac1 &Epac2) in Inflammatory Pain, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| VIRWANI P.D., Zhou L., Wang Y. and Chung S.K., Role of Exchange Protein Directly Activated by cAMP 1 & 2 (Epac1 &Epac2) in Inflammatory Pain, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| VIRWANI P.D., Zhou L., Wang Y. and Chung S.K., Role of Exchange Protein Directly Activated by cAMP 1 & 2 (Epac1& Epac2) in Inflammatory Pain, 11th International Symposium on Healthy Aging. 2016. |
| Researcher : WANG L |
| List of Research Outputs |
| WANG L., ZHANG H., Wong Y.M.E., Tsang S.L., Lendahl U. and Sham M.H., Notch signaling regulates pharyngeal ectoderm development, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Researcher : WANG P |
| List of Research Outputs |
| CHAUDHARY V., Zhang S., Yuen K.S., Li C., Lui P.Y., FUNG S.Y., WANG P., Chan C.P., Li D., Kok K.H., Liang M. and Jin D., Suppression of type I and type III interferon signalling by NSs protein of severe fever-with-thrombocytopenia syndrome virus through inhibition of STAT1 phosphorylation and activation, Journal of General Virology. 2015. |
| QIN Y., KOOHIMOGHADAM M., WANG P., Qin J. and Wang J.J., Machine learning based gene regulatory network inferring with genetics and epigenetics features, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| WANG P., Siu K.L., ZHANG Y., Yang W. and Kok K.H., A novel transcript isoform of STING that suppresses innate antiviral response, The American Society for Virology 34th Annual Meeting. 2015. |
| WANG P., Best Poster Award: Identification and characterization of a novel transcript isoform of STING that dominantly inhibits innate immune response, Hong Kong Immunology Forum 2015: Annual General Meeting of the Hong Kong Society for Immunology. 2015. |
| WANG P., Identification and characterization of a novel transcript isoform of STING that suppresses innate immune response, PhD Thesis, The University of Hong Kong. 2015. |
| YUEN C.K., Chan C.P., FUNG S.Y., WANG P., Wong L.W.M., Tang H.M.V., Yuen K.S., Chan C.P., Jin D. and Kok K.H., Suppression of Type I Interferon Production by Human T-Cell Leukemia Virus Type 1 Oncoprotein Tax through Inhibition of IRF3 Phosphorylation, Journal of Virology. 2016, 90: 3902-3912. |
| Researcher : WANG P |
| List of Research Outputs |
| CHAUDHARY V., Zhang S., Yuen K.S., Li C., Lui P.Y., FUNG S.Y., WANG P., Chan C.P., Li D., Kok K.H., Liang M. and Jin D., Suppression of type I and type III interferon signalling by NSs protein of severe fever-with-thrombocytopenia syndrome virus through inhibition of STAT1 phosphorylation and activation, Journal of General Virology. 2015. |
| QIN Y., KOOHIMOGHADAM M., WANG P., Qin J. and Wang J.J., Machine learning based gene regulatory network inferring with genetics and epigenetics features, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| WANG P., Siu K.L., ZHANG Y., Yang W. and Kok K.H., A novel transcript isoform of STING that suppresses innate antiviral response, The American Society for Virology 34th Annual Meeting. 2015. |
| WANG P., Best Poster Award: Identification and characterization of a novel transcript isoform of STING that dominantly inhibits innate immune response, Hong Kong Immunology Forum 2015: Annual General Meeting of the Hong Kong Society for Immunology. 2015. |
| WANG P., Identification and characterization of a novel transcript isoform of STING that suppresses innate immune response, PhD Thesis, The University of Hong Kong. 2015. |
| YUEN C.K., Chan C.P., FUNG S.Y., WANG P., Wong L.W.M., Tang H.M.V., Yuen K.S., Chan C.P., Jin D. and Kok K.H., Suppression of Type I Interferon Production by Human T-Cell Leukemia Virus Type 1 Oncoprotein Tax through Inhibition of IRF3 Phosphorylation, Journal of Virology. 2016, 90: 3902-3912. |
| Researcher : WONG LYR |
| List of Research Outputs |
| Lui P.Y., WONG L.Y.R., Fung C.L., Siu K.L., Yeung M.L., Yuen K.S., Chan C.P., Woo P.C.Y., Yuen K.Y. and Jin D., Middle East respiratory syndrome coronavirus M protein suppresses type I interferon expression through the inhibition of TBK1-dependent phosphorylation of IRF3, Emerging Microbes & Infections. 2016, 5: e39. |
| Researcher : WONG NCS |
| List of Research Outputs |
| WONG N.C.S., Keung W.W.Y., Chow M.Z.Y., WONG O.T. and Li R.A., Maturation of Human Pluripotent Stem Cell Derived Cardiomyocyte, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| WONG N.C.S., Chow M.Z.Y., Keung W.W.Y. and Li R.A., Maturation of hPSC-CMs in Bioenergetics driven by Oleic Acid and PPARα agonist, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Researcher : WONG OT |
| List of Research Outputs |
| WONG N.C.S., Keung W.W.Y., Chow M.Z.Y., WONG O.T. and Li R.A., Maturation of Human Pluripotent Stem Cell Derived Cardiomyocyte, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Researcher : Wang B |
| List of Research Outputs |
| HO C.C., Wang B., Wong Y.M.E., LIU Y., Hui C.C. and Sham M.H., Best Poster Award: Sufu regulates the cell cycle exit and differentiation of cochlear hair cell progenitors, 2016 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, CUHK, Hong Kong, June 11, 2016. . 2016. |
| HO C.C., Wang B., Wong Y.M.E., LIU Y., HUI C.C. and Sham M.H., Sufu regulates the cell cycle exit and differentiation of cochlear hair cell progenitors, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| LIU Y., Wang B., Wong Y.M.E., Hui C.C. and Sham M.H., The roles of Irx3 and Irx5 genes in inner ear patterning, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Researcher : Wang C |
| Project Title: | Stress Proteins in Growth, Development & Disease; The PERK pathway attenuates ER stress in hypertrophic chondrocytes via SOX9 and FGF21 |
| Investigator(s): | Wang C |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2015 |
| Completion Date: | 07/2015 |
| List of Research Outputs |
| Wang C., Tan Z., Tsang K.Y., Ron D., Itoh N., Chan D. and Cheah K.S.E., The PERK pathway attenuates ER stress in hypertrophic chondrocyte via Sox9 and FGF21., Gordon Research Conference- Stress Proteins in Growth, Development & Disease, Italy, July 5-10, 2015. |
| Researcher : Wang JJ |
| Project Title: | Outstanding Young Researcher Award 2011-12 |
| Investigator(s): | Wang JJ |
| Department: | Biochemistry |
| Source(s) of Funding: | Outstanding Young Researcher Award |
| Start Date: | 01/2013 |
| Project Title: | Understanding the effects of DNA methylation on gene expression - a computational approach |
| Investigator(s): | Wang JJ, Wong MP, Chim JCS |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2015 |
| Project Title: | ISMB/ECCB 2015 / NetBio SIG 2015; Prediction of determining factors and underlying gene regulatory network for cell fate conversion |
| Investigator(s): | Wang JJ |
| Department: | Centre for Genomic Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2015 |
| Completion Date: | 07/2015 |
| List of Research Outputs |
| JIANG Y., Ma C.W., Wang J.J. and Chan Y.S., Orexin modulates inhibitory synaptic transmission of vestibular nuclear neurons in rats [HK. May 18, 2016], Proc. Neuroscience Symposium 2016 & Scientific Conference of The Hong Kong Society of Neurosciences. 2016, 37. |
| JIANG Y., Ma C.W., Wang J.J. and Chan Y.S., Orexin modulates inhibitory synaptic transmission of vestibular nuclear neurons in rats, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| QIN Y., KOOHIMOGHADAM M., WANG P., Qin J. and Wang J.J., Machine learning based gene regulatory network inferring with genetics and epigenetics features, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Researcher : Wang Y |
| Project Title: | Structural basis of sirt6 catalytic mechanism investigation and the inhibitors design |
| Investigator(s): | Wang Y, Hao Q |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2015 |
| Completion Date: | 08/2016 |
| List of Research Outputs |
| GHOSH S., Liu B., Wang Y., Hao Q. and Zhou Z., Lamin A Is an Endogenous SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair, Cell Reports. 2015, 13: 1396-1406. |
| Tong Z., Wang Y., Zhang X.Y., Kim D.D., Sadhukhan S., Hao Q. and Lin H.N., SIRT7 Is Activated by DNA and Deacetylates Histone H3 in the Chromatin Context, ACS Chemical Biology. 2016, 11: 742-747. |
| Researcher : Wong HLX |
| Project Title: | The Biological Functions of MT1-MMP in Lymphatic Vascular Development |
| Investigator(s): | Wong HLX, Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 02/2015 |
| Completion Date: | 10/2015 |
| List of Research Outputs |
| Wong H.L.X., Jin G., Cao R., Zhang S., Cao Y. and Zhou Z., MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis., Nature Communication. 2016, 10824. |
| Researcher : Wong KYG |
| List of Research Outputs |
| YAO H., Jin J., Wong K.Y.G. and Chan C.W.Y., Oxidative Stress Induces Autophagy in Human Embryonic Stem Cell-derived Cardiomyocytes (hESC-CMs), 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Researcher : Wong NS |
| Project Title: | Kappa-opioid receptor mediated cellular stress response: the role of Inositol 1,4,5-trisphosphate and diacylglycerol |
| Investigator(s): | Wong NS, Yao KM |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2002 |
| Project Title: | The relatioship between glycolysis and gluconeogenesis in cancer cells |
| Investigator(s): | Wong NS |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2014 |
| Completion Date: | 04/2016 |
| Project Title: | Cellular stress responses in cancer cells with impaired glycogen metabolism |
| Investigator(s): | Wong NS |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2016 |
| List of Research Outputs |
| YE L., Wong N.S. and Ho J.W.Y., Development of a Prototype Biochemistry Virtual Laboratory: Reflections on the Instructional Design, 5th Annual International Conference on Education & e-Learnning. 2015, 85-90. |
| Researcher : Wong SL |
| List of Research Outputs |
| Wong S.L. and Lu T.K., CombiGEM-CRISPR for Deciphering High-Order Combinatorial Genetics, In: Craig Mak, Cell Systems, Cell Press. Cell Systems, 2016, 2. |
| Wong S.L., Decoding and Engineering Complex Biological Systems, Inaugural Symposium of School of Biomedical Sciences. 2016. |
| Wong S.L., Pairing CombiGEM and CRISPR for Combinatorial Genetic Screening, Addgene's Blog. 2016. |
| Wong S.L., Synthetic biology for functionally interpreting complex genetics, Hong Kong Society for Developmental Biology Summer Meeting. 2016. |
| Researcher : Wong WM |
| List of Research Outputs |
| WU H., Deng R., Chen X., Wong W.M., Chen H., Gao L., Ni Y.C., Wu W. and Shen J., Caveolin-1 Is Critical for Lymphocyte Trafficking into Central Nervous System during Experimental Autoimmune Encephalomyelitis., The Journal of Neuroscience. 2016, 36(19): 5193-5199. |
| Researcher : Wong YME |
| Project Title: | The role of Six1 in controlling the microtubule polymerization during inner ear hair cell bundle formation |
| Investigator(s): | Wong YME, Sham MH |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2015 |
| Project Title: | Genetic analyses of Cdo and Boc function in inner ear development |
| Investigator(s): | Wong YME, Sham MH |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Functional characterization of Six1 on inner ear hair cell ciliary bundle formation |
| Investigator(s): | Wong YME, Sham MH |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 09/2015 |
| List of Research Outputs |
| HO C.C., Wang B., Wong Y.M.E., LIU Y., Hui C.C. and Sham M.H., Best Poster Award: Sufu regulates the cell cycle exit and differentiation of cochlear hair cell progenitors, 2016 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, CUHK, Hong Kong, June 11, 2016. . 2016. |
| HO C.C., Wang B., Wong Y.M.E., LIU Y., HUI C.C. and Sham M.H., Sufu regulates the cell cycle exit and differentiation of cochlear hair cell progenitors, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| LIANG Y., Wong Y.M.E., LIU Y., Krauss R.S., Xu P.X., Hui C.C. and Sham M.H., The role of Hedgehog receptor Cdo in controlling cochlear hair cell and pillar cell formation, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| LIANG Y., Wong Y.M.E., LIU Y., Hui C.C. and Sham M.H., The role of Hedgehog receptor Cdo in controlling cochlear hair cell and pillar cell formation, Hong Kong Inter-University Postgraduate symposium in Biochemical Sciences 2016. |
| LIU Y., Wang B., Wong Y.M.E., Hui C.C. and Sham M.H., The roles of Irx3 and Irx5 genes in inner ear patterning, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| WANG L., ZHANG H., Wong Y.M.E., Tsang S.L., Lendahl U. and Sham M.H., Notch signaling regulates pharyngeal ectoderm development, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Wong Y.M.E., Xu C.Y., Brahmachary M. and Xu P.X., A novel ENU-induced mutation in Myo6 causes vestibular dysfunction and deafness, PLOS ONE. PLOS ONE, 2016, 11: e0154984. |
| Wong Y.M.E. and Sham M.H., Unraveling the genetics and pathogenesis of hearing loss in Eya1/Six1 associated Branchio-Oto-Renal syndrome and implications in therapeutic development. , Hearing Research Meeting in South University of Science and Technology of China, Shenzhen, China. 15 Dec 2015.. 2015. |
| Researcher : Wu MH |
| List of Research Outputs |
| Liu A.J., RAO Y., Cheung M.P.L., Hui M.N., Wu M.H., Niu B., Chan L.K., Cheah K.S.E. and Cheung M.C.H., Coordinated action of Nedd9 and Dlc1 in neural crest motility, Proceedings of Avian Model Systems 9: A New Integrative Platform. 2016. |
| Liu A.J., Ho S.H., Hui M.N., Cheung M.P.L., Wu M.H., Ho C.K.I., Niu B., Cheah K.S.E. and Cheung M.C.H., Sox9-dependent pathway in regulating neural crest cell motility, Neural Crest & Cranial Placodes Gordon Research Conference Development, Malformations and Cancers. 2015. |
| Tsang K.Y., Wu M.H., Zhang M., Gu J., Yu X. and Chan D., Dissecting the transition from hypertrophic chondrocyte to osteoblast in skeletal development and growth, Gordon Research Conference on Bones & Teeth, Galveston, TX, USA, February 14-19, 2016. |
| Tsang K.Y., Wu M.H., Zhang M., Gu J., Yu X., Chan D. and Cheah K.S.E., Dissecting the transition from hypertrophic chondrocyte to osteoblast in skeletal development and growth, Gordon Research Conference – Bones & Teeth, Galveston, TX, USA, February 14-19, 2016. |
| Researcher : Wu W |
| Project Title: | Effects of chondroitinase ABC and lithium chloride on neuronal survival and regeneration after spinal cord injury |
| Investigator(s): | Wu W, Yick LW, So KF |
| Department: | Anatomy |
| Source(s) of Funding: | Matching Fund for National Key Basic Research Development Scheme (973 Projects) |
| Start Date: | 11/2003 |
| Project Title: | Research Output Prize |
| Investigator(s): | Wu W, Su H, Wong WM, So KF, Wu EX |
| Department: | Anatomy |
| Source(s) of Funding: | Research Output Prize (in Faculty) |
| Start Date: | 10/2008 |
| Project Title: | Fabrication of a bioactive nanofibrous conduit for functional recovery of spinal cord injury |
| Investigator(s): | Wu W |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2014 |
| Completion Date: | 04/2016 |
| Project Title: | Bridge the gap in nerve tissue injury to promote axonal regeneration with fabrication of a bioactive nanofibrous conduit |
| Investigator(s): | Wu W |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 07/2014 |
| Project Title: | Spinal cord injury in developing and adult rats: different outcome and potential mechanisms. |
| Investigator(s): | Wu W |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 03/2015 |
| Project Title: | Repairing neural damage after spinal cord injury with self-assembling peptide nanofiber scaffold (SAPNS) |
| Investigator(s): | Wu W |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2015 |
| Project Title: | Enhancing axonal regeneration of spinal motoneurons after root avulsion by manipulation of chondroitin sulfate proteoglycans (CSPGs) |
| Investigator(s): | Wu W |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2016 |
| List of Research Outputs |
| DUAN Z., Fung M.L., Wu W., Lo A.C.Y., Xia J. and Huang J., Kinesin-1 regulates extrasynaptic NMDAR targeting and its reduction can confer neuroprotection, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| DUAN Z., Fung M.L., Ni Y., Wu W., Chan Y.S. and Huang J., Kinesin-1 regulates extrasynaptic NMDAR targeting and its reduction can confer neuroprotection, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| Heng B.C.A., Lim L.W., Wu W. and Zhang C., An overview of protocols for the neural induction of dental and oral stem cells in vitro, In: Antonios G. Mikos; John P. Fisher, Tissue Engineering Part B: Reviews . Mary Ann liebert, 2016, 22 (3): 220-250. |
| Lai H.M., LIU K.L., Ng W.L., DeFelice J., Lee W.S., LI H., LI W., NG H.M., Chang R.C.C., Lin B., Wu W. and Gentleman S.M., Rationalisation and validation of an acrylamide-free procedure in three-dimensional histological imaging, PloS One. 2016, 11: e0158628. |
| Lee C.D., Lau B.W.M., Yau S.Y., Leung J.W.H., Wong K.H.H., Lee T.M.C., Wu W. and So K.F., Motor Training Reduces Psychomotor Retardation via Gliogenesis in Rats with Depression-like Behaviour, Neuroscience Symposium 2016 & Annual Scientific Conference of The Hong Kong Society of Neurosciences: Nature and Nurture in Brain Functions. 2016. |
| WU H., Deng R., Chen X., Wong W.M., Chen H., Gao L., Ni Y.C., Wu W. and Shen J., Caveolin-1 Is Critical for Lymphocyte Trafficking into Central Nervous System during Experimental Autoimmune Encephalomyelitis., The Journal of Neuroscience. 2016, 36(19): 5193-5199. |
| Researcher : XIE S |
| List of Research Outputs |
| LI T., Lian F., Xie S., DU Y. and Qian C., Molecular insights into histone H3 ubiquitination dependent maintenance DNA methylation, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Lian F., Xie S. and Qian C., Crystal structure and SUMO binding of Slx1-Slx4 complex, Scientific Reports. 2016, 6: 19331. |
| XIE S., Mortuewicz O., Ma H., Poon R., Helleday T. and Qian C., Timeless interacts with PARP-1 to promote DNA repair, IAS Focused Program on Genome Damage and Stability . 2015. |
| Xie S., Mortusewicz O., Ma H., Herr P., Poon R., Helleday T. and Qian C., Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair, Molecular Cell. 2015. |
| Xie S., Mortusewicz O., Ma H., Poon R., Helleday T. and Qian C., Timeless interacts with PARP-1 to promote DNA Double-strand Break repair, 1st Cold Spring Harbor Asia conference on DNA Metabolism, Genomic Stability and Diseases . 2016. |
| Xie S., Mortusewicz O., Ma H., Poon R., Helleday H. and Qian C., Timeless interacts with PARP-1 to promote DNA Double-strand Break repair, 4th Cold Spring Harbor Asia conference on Chromatin, Epigenetics and Transcription . 2016. |
| Researcher : XIONG C |
| List of Research Outputs |
| XIONG C., LI Y., RAI F.M., SANDELL L., ZHANG Y., Song Y., Cheah K.S.E., Sham P.C. and Chan D., Genetic contribution to degeneration and repair potentials of the intervertebral disc in mice, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| XIONG C., LI Y., Rai F.M., Sham P.C., ZHANG Y., Song Y., Cheah K.S.E. and Chan D., Genetic contribution to intervertebral discs integrity maintenance in mouse model, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Researcher : XU F |
| List of Research Outputs |
| XU F., Computational methodologies for genomics and proteomics data analysis, PhD Thesis, The University of Hong Kong. 2015. |
| Researcher : XU W |
| List of Research Outputs |
| CHEN X., ZHU S., XU W. and Chen J., Regional Disturbances Around the F508 Residues Exhibited Various Impacts on The function of The Cystic Fibrosis Transmembrane Conductance Regulator, ATP-binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases. 2016. |
| CHEN X., ZHU S., XU W. and Chen J., Regional Disturbances Around the F508 Residues Exhibited Various Impacts on The function of The Cystic Fibrosis Transmembrane Conductance Regulator, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Li B., XU W., Guan X., Qin Y...R..., Law S.Y.K., Lee N.P.Y., Chan K.T., Tam P.Y., Li Y.Y., Chan K.W., Yuen H...F..., Tsao G.S.W., He Q...Y... and Cheung A., Competitive Binding Between Id1 and E2F1 to Cdc20 Regulates E2F1 Degradation and Thymidylate Synthase Expression to Promote Esophageal Cancer Chemoresistance, Clinical Cancer Research. 2016, 22: 1243-1255. |
| Li B., Xu W., Liu J. and Cheung A., Identification of miR-29c/FBXO31 as a key regulatory mechanism in esophageal cancer chemoresistance, International Conference on Antimicrobial Agents and Chemotherapy, Valencia, Spain, August 04-06, 2015. |
| Li J., Li B., XU W., Chan K.W., Guan X., Qin Y.R., Lee N.P.Y., Chan K.T., Law S.Y.K., Tsao G.S.W. and Cheung A., Role of AMPK signaling in mediating the anticancer effects of silibinin in esophageal squamous cell carcinoma, Expert Opinion on Therapeutic Targets. 2016, 20: 7-18. |
| XU W., Li N.F. and Chen J., Apical Na+ is required for decreasing transepithelial Na+ current of cultured pig tracheal epithelia by the apical Krebs solution, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| XU W., Li N.F. and Chen J., Contact-dependent virulence of P. aeruginosa is required for elevating paracellular conductance of cultured pig tracheal epithelia, 29th Annual North American Cystic Fibrosis Conference. 2015. |
| XU W., Li N.F. and Chen J., Effects of the apical Krebs solution on ion transport of cultured pig tracheal epithelia, American Thoracic Society (ATS) 2016 International Conference. 2016. |
| XU W., Li N.F. and Chen J., Effects of the apical Krebs solution on ion transport of cultured pig tracheal epithelia, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Xu W., Li B. and Cheung A., Role of miR-29c in modulating the paracrine crosstalk between esophageal cancer cells and stromal fibroblasts in the tumor microenvironment, International Conference on Antimicrobial Agents and Chemotherapy, Valencia, Spain, August 04-06, 2015. |
| ZHU S., XU W., Li N.F. and Chen J., Roles of bicarbonate ion in ion transport and bacterial killing of cultured pig tracheal epithelia, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Researcher : XU W |
| List of Research Outputs |
| CHEN X., ZHU S., XU W. and Chen J., Regional Disturbances Around the F508 Residues Exhibited Various Impacts on The function of The Cystic Fibrosis Transmembrane Conductance Regulator, ATP-binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases. 2016. |
| CHEN X., ZHU S., XU W. and Chen J., Regional Disturbances Around the F508 Residues Exhibited Various Impacts on The function of The Cystic Fibrosis Transmembrane Conductance Regulator, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Li B., XU W., Guan X., Qin Y...R..., Law S.Y.K., Lee N.P.Y., Chan K.T., Tam P.Y., Li Y.Y., Chan K.W., Yuen H...F..., Tsao G.S.W., He Q...Y... and Cheung A., Competitive Binding Between Id1 and E2F1 to Cdc20 Regulates E2F1 Degradation and Thymidylate Synthase Expression to Promote Esophageal Cancer Chemoresistance, Clinical Cancer Research. 2016, 22: 1243-1255. |
| Li B., Xu W., Liu J. and Cheung A., Identification of miR-29c/FBXO31 as a key regulatory mechanism in esophageal cancer chemoresistance, International Conference on Antimicrobial Agents and Chemotherapy, Valencia, Spain, August 04-06, 2015. |
| Li J., Li B., XU W., Chan K.W., Guan X., Qin Y.R., Lee N.P.Y., Chan K.T., Law S.Y.K., Tsao G.S.W. and Cheung A., Role of AMPK signaling in mediating the anticancer effects of silibinin in esophageal squamous cell carcinoma, Expert Opinion on Therapeutic Targets. 2016, 20: 7-18. |
| XU W., Li N.F. and Chen J., Apical Na+ is required for decreasing transepithelial Na+ current of cultured pig tracheal epithelia by the apical Krebs solution, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| XU W., Li N.F. and Chen J., Contact-dependent virulence of P. aeruginosa is required for elevating paracellular conductance of cultured pig tracheal epithelia, 29th Annual North American Cystic Fibrosis Conference. 2015. |
| XU W., Li N.F. and Chen J., Effects of the apical Krebs solution on ion transport of cultured pig tracheal epithelia, American Thoracic Society (ATS) 2016 International Conference. 2016. |
| XU W., Li N.F. and Chen J., Effects of the apical Krebs solution on ion transport of cultured pig tracheal epithelia, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Xu W., Li B. and Cheung A., Role of miR-29c in modulating the paracrine crosstalk between esophageal cancer cells and stromal fibroblasts in the tumor microenvironment, International Conference on Antimicrobial Agents and Chemotherapy, Valencia, Spain, August 04-06, 2015. |
| ZHU S., XU W., Li N.F. and Chen J., Roles of bicarbonate ion in ion transport and bacterial killing of cultured pig tracheal epithelia, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Researcher : XU Y |
| List of Research Outputs |
| XU Y., Studying signaling regulators of neurogenesis during mammalian central nervous system development, MPhil Thesis, The University of Hong Kong. 2015. |
| Researcher : XUE W |
| List of Research Outputs |
| XUE W., Study of kinesin-1 functions on cartilage and chondrocytes, PhD Thesis , The University of Hong Kong. 2016. |
| Researcher : Xie S |
| List of Research Outputs |
| LI T., Lian F., Xie S., DU Y. and Qian C., Molecular insights into histone H3 ubiquitination dependent maintenance DNA methylation, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Lian F., Xie S. and Qian C., Crystal structure and SUMO binding of Slx1-Slx4 complex, Scientific Reports. 2016, 6: 19331. |
| XIE S., Mortuewicz O., Ma H., Poon R., Helleday T. and Qian C., Timeless interacts with PARP-1 to promote DNA repair, IAS Focused Program on Genome Damage and Stability . 2015. |
| Xie S., Mortusewicz O., Ma H., Herr P., Poon R., Helleday T. and Qian C., Timeless Interacts with PARP-1 to Promote Homologous Recombination Repair, Molecular Cell. 2015. |
| Xie S., Mortusewicz O., Ma H., Poon R., Helleday T. and Qian C., Timeless interacts with PARP-1 to promote DNA Double-strand Break repair, 1st Cold Spring Harbor Asia conference on DNA Metabolism, Genomic Stability and Diseases . 2016. |
| Xie S., Mortusewicz O., Ma H., Poon R., Helleday H. and Qian C., Timeless interacts with PARP-1 to promote DNA Double-strand Break repair, 4th Cold Spring Harbor Asia conference on Chromatin, Epigenetics and Transcription . 2016. |
| Researcher : YANG X |
| List of Research Outputs |
| YANG X. and Cheung M.C.H., Elucidating the role of DLC1 in Metastatic Melanoma, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| YANG X., Novel Posttranslational Modification of UHRF1 and its Biological Relevance, PhD Thesis, 2016. |
| YANG X., Lui W.C., Lam Y.M. and Ng R.K., Study of epigenetic dysregulation in MLL-rearranged leukemia, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Researcher : YANG X |
| List of Research Outputs |
| YANG X. and Cheung M.C.H., Elucidating the role of DLC1 in Metastatic Melanoma, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| YANG X., Novel Posttranslational Modification of UHRF1 and its Biological Relevance, PhD Thesis, 2016. |
| YANG X., Lui W.C., Lam Y.M. and Ng R.K., Study of epigenetic dysregulation in MLL-rearranged leukemia, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Researcher : YANG X |
| List of Research Outputs |
| YANG X. and Cheung M.C.H., Elucidating the role of DLC1 in Metastatic Melanoma, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| YANG X., Novel Posttranslational Modification of UHRF1 and its Biological Relevance, PhD Thesis, 2016. |
| YANG X., Lui W.C., Lam Y.M. and Ng R.K., Study of epigenetic dysregulation in MLL-rearranged leukemia, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Researcher : YAO H |
| List of Research Outputs |
| YAO H., Jin J., Wong K.Y.G. and Chan C.W.Y., Oxidative Stress Induces Autophagy in Human Embryonic Stem Cell-derived Cardiomyocytes (hESC-CMs), 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Researcher : YE L |
| List of Research Outputs |
| YE L., Wong N.S. and Ho J.W.Y., Development of a Prototype Biochemistry Virtual Laboratory: Reflections on the Instructional Design, 5th Annual International Conference on Education & e-Learnning. 2015, 85-90. |
| Researcher : YIP KHR |
| List of Research Outputs |
| Cheah K.S.E., Au Y.K., Wynn S., Tan T., YIP K.H.R. and Chan D., Genetic control of hypertrophic chondrocyte to osteoblast differentiation in development and skeletal disorders, American Association of Anatomists (AAA) 2016 Annual Meeting. 2016. |
| Cheah K.S.E., Au Y.K., Wynn S., Tan T., YIP K.H.R. and Chan D., Genetic control of hypertrophic chondrocyte to osteoblast differentiation in development and skeletal disorders, American Association of Anatomists (AAA) 2016 Annual Meeting, San Diego, USA, April 2-6, 2016.. 2016. |
| YIP K.H.R., Au Y.K., Chan D. and Cheah K.S.E., Investigating molecular pathogenesis of Campomelic Dysplasia, 2016 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| YIP K.H.R., Au Y.K., Chan D. and Cheah K.S.E., Investigating molecular pathogenesis of Campomelic Dysplasia, 2016 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences, The Chinese University of Hong Kong, June 11, 2016. |
| YIP K.H.R., Au Y.K., Chan D. and Cheah K.S.E., Investigating molecular pathogenesis of Campomelic Dysplasia, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Researcher : YOU R |
| List of Research Outputs |
| Poon C.H., Ho Y.S., YOU R., Tse J., Chiu K. and Chang R.C.C., PKR deficiency alters E. coli-induced sickness behaviors but does not exacerbate neuroimmune responses or bacterial load., Journal of Neuroinflammation. 2015, 12: 1-19. |
| YOU R., Cheng S.Y., Hung H.L.C., Ho Y.S., Lai S.W.C. and Chang R.C.C., Investigating the effects of silica nanoparticles on affective and cognitive behaviors and on synapse in vivo and in vitro. , International Alzheimer’s Disease Conference 2016. 64. |
| YOU R., Cheng S.Y., Hung H.L.C., Ho Y.S. and Chang R.C.C., Investigating the impact of Silica Nanoparticles on affective and cognitive behaviors, and on synapse in vivo and in vitro. , The 11th International Conference on Healthy Aging. 2016, 61. |
| Researcher : Yan B |
| Project Title: | Uncovering combinatorial regulation of transcription factors and microRNAs on cardiomyocyte differentiation from pluripotent stem cells |
| Investigator(s): | Yan B, Boheler KR |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2016 |
| List of Research Outputs |
| Qin J., Yan B., Hu Y., Wang P. and Wang J.J., Applications of Integrative OMICs Approaches to Gene Regulation Studies, Quantitative Biology. 2016, 2: in press. |
| Si H., Lu H., Yang X., Mattox A., Jang M., Bian Y., Sano E., Viadiu H., Yan B., Yau C., Ng S., Lee S.K., Romano R.A., Davis S., Walker R.L., Xiao W., Sun H., Wei L., Sinha S., Benz C.C., Stuart J.M., Meltzer P.S., Van Waes C. and Chen Z., TNF-alpha modulates genome-wide redistribution of DeltaNp63alpha/TAp73 and NF-kappaB cREL interactive binding on TP53 and AP-1 motifs to promote an oncogenic gene program in squamous cancer, Oncogene. 2016. |
| Wang J.J., Yan B., Liu S.M., Sun H., Pan Y., Guan D., Zhang X., Xu J. and Ma H., Transcriptomic and Functional Pathway Analysis of Human Cervical Carcinoma Cancer Cells Response to Microtubule Inhibitor, J Cancer. 2015, 6(10): 930-7. |
| Yan B., Integrating high-throughput Omics data to dissect gene regulation complexity in stem cell differentiation, Symposium of water and environments 12-2015. 2015. |
| Yan B., Integrating high-throughput data to dissect gene regulation complexity , Seminar of CGS, HKU. 2015. |
| Zhang J., Yan B., Spath S.S., Qun H., Cornelius S., Guan D., Shao J., Hagiwara K., Van Waes C., Chen Z., Su X. and Bi Y., Integrated transcriptional profiling and genomic analyses reveal RPN2 and HMGB1 as promising biomarkers in colorectal cancer, Cell Biosci. 2015, 5: 53. |
| Researcher : Yao KM |
| Project Title: | Regulation of Bmi-1 expression by the Forkhead box transcription factor FoxM1 |
| Investigator(s): | Yao KM |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2007 |
| Project Title: | Investigating the role of FOXM1 in the maintenance of human embryonic stem cell pluripotency and genome stability |
| Investigator(s): | Yao KM, Cheung MCH |
| Department: | Biochemistry |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2012 |
| Project Title: | Secreted PDZ domain-containing protein 2 and regulation of Sonic hedgehog signaling during neural tube development |
| Investigator(s): | Yao KM, Cheung MCH |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2013 |
| Completion Date: | 12/2015 |
| Project Title: | Elucidating the nuclear function of EPS8/EPS8L2: Crosstalk with FOXM1 and regulation of cancer cell proliferation and migration/invasion |
| Investigator(s): | Yao KM, Chan DW |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2014 |
| Project Title: | Identifying the cognate receptor of secreted PDZD2 |
| Investigator(s): | Yao KM |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2015 |
| Project Title: | Investigating the signalling function of secreted PDZD2 |
| Investigator(s): | Yao KM, Wang JJ |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 08/2015 |
| List of Research Outputs |
| FAN W., Huang J., Yao K.M. and Huang W., Toward exploring pluripotency landscape through light-induced tuning of Oct4 expression, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Ho J.W.Y., Kwok D., Yao K.M., Chan L.K. and Ho J., Breathing life into the concepts of biochemistry – From bedside to benchside, Frontiers in Medical and Health Sciences Education. 2015. |
| Ho J.W.Y., Yao K.M., Song Y., Chan L.K., Cook S. and Bridges S.M., Teaching Development Grant, The University Of Hong Kong. 2015. |
| Kwok C.T.D., LEUNG M.H., Qin J., QIN Y., Wang J.J., Lee C.Y.L. and Yao K.M., The Forkhead box transcription factor FOXM1 is required for the maintenance of cell proliferation and protection against oxidative stress in human embryonic stem cells, Stem Cell Research. 2016. |
| SO H.F., Shiu S.Y.W. and Yao K.M., Glucose-regulated expression and processing of PDZD2 in mouse islets and rat INS-1E beta cells, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| WONG S.Y., Yao K.M., Chan B.P. and Lo A.C.Y., Terminable Encapsulated-Cell Drug Delivery Device for Safer Ocular Applications, 11th International Symposium on Healthy Aging: “Science and Aging: An Era of Discovery”. 2016. |
| Researcher : Yip YL |
| Project Title: | Establishment and characterization of representative nasopharyngeal carcinoma cell lines |
| Investigator(s): | Yip YL, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2014 |
| Completion Date: | 08/2015 |
| List of Research Outputs |
| Jia L.J., Tsang C.M., Yip Y.L., Law W., ZHANG J., Deng W. and Tsao G.S.W., Establishment and characterization of immortalized nasopharyngeal epithelial cells with stable infection of Epstein-Barr virus, Gordon Research Conference - Nasopharyngeal Carcinoma. 2016. |
| LIN W., Yip Y.L., LO K.W., Deng W. and Tsao G.S.W., Establishment of a new cell line of nasopharyngeal carcinoma, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Su H., Tiwari A.F.Y., Ngan H.Y.S., Yip Y.L., Cheung A., Tsao G.S.W. and Deng W., Extremely stringent activation of p16INK4a prevents immortalization of uterine cervical epithelial cells without human papillomavirus oncogene expression, Oncotarget. 2016. |
| ZHANG J., Jia L.J., LIN W., Yip Y.L., Tsang C.M., Zhou Y., Zhu D., Deng W. and Tsao G.S.W., Significance of Epstein-Barr virus encoded Latent Membrane Protein 1-Induced mTOR Signaling in Nasopharyngeal Cells, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| ZHU D., ZHANG J., Deng W., Yip Y.L., Lung H.L., Tsang C.M., Law W.T., Yang J., Lau M.Y., Lung M.L., Cheung A. and Tsao G.S.W., Significance of NF-kB activation in immortalization of nasopharyngeal epithelial cells., Int. J. Cancer. 2015. |
| Researcher : Yu B |
| Project Title: | Study of LPS effect in Salmonella-tumor interactions by using intravital imaging in vivo |
| Investigator(s): | Yu B, Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2015 |
| Completion Date: | 06/2016 |
| List of Research Outputs |
| Cui J., Jin G.X., Yu B., Wang Z., Lin R.Z. and Huang J., Stable knockdown of Kif5b in MDCK cells leads to epithelial–mesenchymal transition, Biochemical and Biophysical Research Communications. 2015, 463: 123-129. |
| Guo Z., Yu B., Ning B.T., Chan S., Lin Q., Li C.B., Huang J. and Chan G.C.F., Genetically modified "obligate" anaerobic Salmonella typhimurium as a therapeutic strategy for neuroblastoma, Journal of Hematology & Oncology. 2015, 8. |
| Shi L., Yu B., Cai C.H., Huang W., Zheng B., Smith D.K. and Huang J., Combined prokaryotic–eukaryotic delivery and expression of therapeutic factors through a primed autocatalytic positive-feedback loop, Journal of Controlled Release. 2016, 222: 130-140. |
| Researcher : Yu C |
| Project Title: | Down-regulation of integrin-beta3 by clathrin-mediated endocytosis |
| Investigator(s): | Yu C |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 11/2014 |
| Project Title: | Investigating phosphatidylinositol lipid signaling at the cancer invadosome |
| Investigator(s): | Yu C |
| Department: | Anatomy |
| Source(s) of Funding: | Early Career Scheme (ECS) |
| Start Date: | 09/2015 |
| Project Title: | The mechanism of Cdc42 regulation in podosome assembly |
| Investigator(s): | Yu C |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2016 |
| Project Title: | Gordon Research Conference: Signaling by Adhesion Receptors; Regulation of integrin-beta3 endocytosis at adhesion sites |
| Investigator(s): | Yu C |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2016 |
| Completion Date: | 06/2016 |
| List of Research Outputs |
| Biswas K., Hartman K., Yu C., Harrison O., Song H., Smith A., Huang W., Lin W., Guo Z., Padmanabhan A., Troyanovsky S., Dustin M., Shapiro L., Honig B., Zaidel-Bar R. and Groves J., E-cadherin junction formation involves an active kinetic nucleation process, Proceedings of the National Academy of Sciences. 2015, 201513775. |
| Yu C., Adhesion formation and transformation at the cell-matrix interface, 11th Asia-Pacific Microscopy Conference (APMC11), Phuket, Thailand, May 23-27, 2016.. 2016. |
| Yu C., Adhesion signaling and endocytosis of integrin receptors, Max Planck Society - Croucher Foundation Joint Workshop on Molecular Systems and Engineering Sciences (5-7th April, 2016) . 2016. |
| Yu C., Adhesion transformation, integrin signaling, and endocytosis in the absence of matrix force , Croucher Symposium in Advanced Imaging. 2015. |
| Yu C., Rafiq N.B.M., CAO F., ZHOU Y., Krishnasamy A., Biswas K.H., Ravasio A., Chen Z., Wang Y., Kawauchi K., Jones G.E. and Sheetz M.P., Integrin-beta3 clusters recruit clathrin-mediated endocytic machinery in the absence of traction force, Nature Communications. 2015, 6: 8672. |
| Yu C., Mechanical cues during cell invasion, Intracellular Traffic in Health and Disease, 7th HKU- PASTEUR CELL BIOLOGY COURSE (6-18th March 2016). 2016. |
| Yu C., Signal transduction at integrin receptors: adhesion transformation and ligand endocytosis, Seminar of School of Biomedical Sciences, HKU (25th Feb, 2016). 2016. |
| Yu C., The turnover of integrin-mediated adhesion via endocytosis, Symposium on Genetics, Developmental Genomics and Stem Cells (9th January 2016). 2016. |
| Researcher : Yuen KS |
| Project Title: | 34th Annual Meeting of the American Society for Virology (ASV2015); Targeted genome editing of Epstein-Barr virus by CRISPR/Cas9 technology in human cells |
| Investigator(s): | Yuen KS |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2015 |
| Completion Date: | 07/2015 |
| List of Research Outputs |
| CHAUDHARY V., ZHANG S., Yuen K.S., LI D., Kok K.H., LIANG M. and Jin D., Opposite effect of severe fever-with-thrombocytopenia syndrome virus NSs protein on type I and type II interferon signaling, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| CHAUDHARY V., Zhang S., Yuen K.S., Li C., Lui P.Y., FUNG S.Y., WANG P., Chan C.P., Li D., Kok K.H., Liang M. and Jin D., Suppression of type I and type III interferon signalling by NSs protein of severe fever-with-thrombocytopenia syndrome virus through inhibition of STAT1 phosphorylation and activation, Journal of General Virology. 2015. |
| Jin D., Siu K.L., Yuen K.S., Yeung M.L., Kok K.H. and Yuen K.Y., Activation of NLRP3 inflammasomes by severe acute respiratory syndrome coronavirus 3a protein, The American Society for Virology 34th Annual Meeting. 2015. |
| Jin D., Tang H.M.V., GAO W., Chan C.P., Iha H. and Yuen K.S., Suppression of HTLV-1 transcription by SIRT1 deacetylase, Retrovirology. 2015, 12: P53. |
| Lui P.Y., WONG L.Y.R., Fung C.L., Siu K.L., Yeung M.L., Yuen K.S., Chan C.P., Woo P.C.Y., Yuen K.Y. and Jin D., Middle East respiratory syndrome coronavirus M protein suppresses type I interferon expression through the inhibition of TBK1-dependent phosphorylation of IRF3, Emerging Microbes & Infections. 2016, 5: e39. |
| Tang H.M.V., GAO W., Chan C.P., CHENG Y., Deng J., Yuen K.S., Iha H. and Jin D., SIRT1 Suppresses Human T-Cell Leukemia Virus Type 1 Transcription, Journal of Virology. 2015, 89: 8623-8631. |
| YUEN C.K., Chan C.P., FUNG S.Y., WANG P., Wong L.W.M., Tang H.M.V., Yuen K.S., Chan C.P., Jin D. and Kok K.H., Suppression of Type I Interferon Production by Human T-Cell Leukemia Virus Type 1 Oncoprotein Tax through Inhibition of IRF3 Phosphorylation, Journal of Virology. 2016, 90: 3902-3912. |
| Yuen K.S., ASV 2015 Postdoctoral Fellow Travel Award, AMERICAN SOCIETY FOR VIROLOGY. 2015. |
| Yuen K.S., American Society for Virology Travel Award: Targeted genome editing of Epstein-Barr virus by CRISPR/Cas9 technology in human cells, The American Society for Virology 34th Annual Meeting. 2015. |
| Researcher : ZHANG H |
| List of Research Outputs |
| WANG L., ZHANG H., Wong Y.M.E., Tsang S.L., Lendahl U. and Sham M.H., Notch signaling regulates pharyngeal ectoderm development, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| ZHANG H., Eya1/Six1 and Notch signaling in branchial arch development, PhD Thesis, The University of Hong Kong. 2016. |
| Researcher : ZHANG J |
| List of Research Outputs |
| Jia L.J., Tsang C.M., Yip Y.L., Law W., ZHANG J., Deng W. and Tsao G.S.W., Establishment and characterization of immortalized nasopharyngeal epithelial cells with stable infection of Epstein-Barr virus, Gordon Research Conference - Nasopharyngeal Carcinoma. 2016. |
| ZHANG J., Lau M.Y., ZHU D. and Tsao G.S.W., Functional Study of Epstein-Barr virus Encoded Latent Membrane Protein 1 (LMP1)-Induced mTOR Activation in Nasopharyngeal Carcinoma Cell, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| ZHANG J., Jia L.J., LIN W., Yip Y.L., Tsang C.M., Zhou Y., Zhu D., Deng W. and Tsao G.S.W., Significance of Epstein-Barr virus encoded Latent Membrane Protein 1-Induced mTOR Signaling in Nasopharyngeal Cells, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| ZHU D., ZHANG J., Deng W., Yip Y.L., Lung H.L., Tsang C.M., Law W.T., Yang J., Lau M.Y., Lung M.L., Cheung A. and Tsao G.S.W., Significance of NF-kB activation in immortalization of nasopharyngeal epithelial cells., Int. J. Cancer. 2015. |
| Researcher : ZHANG S |
| List of Research Outputs |
| CHAUDHARY V., ZHANG S., Yuen K.S., LI D., Kok K.H., LIANG M. and Jin D., Opposite effect of severe fever-with-thrombocytopenia syndrome virus NSs protein on type I and type II interferon signaling, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Wong H.L.X., Jin G., Cao R., Zhang S., Cao Y. and Zhou Z., MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis., Nature Communication. 2016, 10824. |
| Researcher : ZHANG W |
| List of Research Outputs |
| ZHANG W., Structural Study on Motor Protein and Virulence Factors, PhD Thesis, The University of Hong Kong. 2015. |
| Researcher : ZHANG Y |
| List of Research Outputs |
| XIONG C., LI Y., RAI F.M., SANDELL L., ZHANG Y., Song Y., Cheah K.S.E., Sham P.C. and Chan D., Genetic contribution to degeneration and repair potentials of the intervertebral disc in mice, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| XIONG C., LI Y., Rai F.M., Sham P.C., ZHANG Y., Song Y., Cheah K.S.E. and Chan D., Genetic contribution to intervertebral discs integrity maintenance in mouse model, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Researcher : ZHANG Z |
| List of Research Outputs |
| ZHANG Z., Shea Y.F., Chu L.W. and Song Y., Circulating MicroRNAs in Plasma as Novel Biomarkers for Alzheimer’s Disease, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| Zhang Z., Circulating MicroRNAs in Plasma as Novel Biomarkers of Alzheimer’s Disease, MMedSc Dissertation, The University of Hong Kong. 2015. |
| Zhang Z., Li Y., Ng C.T. and Song Y., Inflammation in Alzheimer's Disease and Molecular Genetics: Recent Update, Arch Immunol Ther Exp (Warsz). 2015. |
| Researcher : ZHOU P |
| List of Research Outputs |
| ZHOU P., Role of Atg16L1 in the transport of autophagic vesicles in primary cultured neurons and novel kinases regulating autophagy in fission yeast, PhD Thesis, The University of Hong Kong. 2016. |
| Researcher : ZHOU Y |
| List of Research Outputs |
| Li S.K., TANG H.C., Lau P.Y., Zhou Y. and Ching Y.P., HBx targets centrosomal protein TAX1BP2 to promote genomic instability., Cell Symposium – Human Genomics. 2015. |
| Li S.K., TANG H.C., Lau P.Y., Zhou Y. and Ching Y.P., HBx targets centrosomal protein TAX1BP2 to promote genomic instability, In: Genome Institute of Singapore, A*Star, Cell Symposium - Human Genomic, Singapore. 2015. |
| Xu Y.M., Wu D.D., Zheng W., Yu F.Y., Yang F., Yao Y., Zhou Y., Ching Y.P. and Lau T.Y., Proteome profiling of cadmium-induced apoptosis by antibody array analyses in human bronchial epithelial cells., Oncotarget. Impact Journals, 2015, 7: 6146-6158. |
| Yu C., Rafiq N.B.M., CAO F., ZHOU Y., Krishnasamy A., Biswas K.H., Ravasio A., Chen Z., Wang Y., Kawauchi K., Jones G.E. and Sheetz M.P., Integrin-beta3 clusters recruit clathrin-mediated endocytic machinery in the absence of traction force, Nature Communications. 2015, 6: 8672. |
| ZHANG J., Jia L.J., LIN W., Yip Y.L., Tsang C.M., Zhou Y., Zhu D., Deng W. and Tsao G.S.W., Significance of Epstein-Barr virus encoded Latent Membrane Protein 1-Induced mTOR Signaling in Nasopharyngeal Cells, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| ZHOU Y., Dynamics of Epstein-Barr virus episomes in infected epithelial cells, PhD Thesis, The University of Hong Kong. 2016. |
| Researcher : ZHOU Y |
| List of Research Outputs |
| Li S.K., TANG H.C., Lau P.Y., Zhou Y. and Ching Y.P., HBx targets centrosomal protein TAX1BP2 to promote genomic instability., Cell Symposium – Human Genomics. 2015. |
| Li S.K., TANG H.C., Lau P.Y., Zhou Y. and Ching Y.P., HBx targets centrosomal protein TAX1BP2 to promote genomic instability, In: Genome Institute of Singapore, A*Star, Cell Symposium - Human Genomic, Singapore. 2015. |
| Xu Y.M., Wu D.D., Zheng W., Yu F.Y., Yang F., Yao Y., Zhou Y., Ching Y.P. and Lau T.Y., Proteome profiling of cadmium-induced apoptosis by antibody array analyses in human bronchial epithelial cells., Oncotarget. Impact Journals, 2015, 7: 6146-6158. |
| Yu C., Rafiq N.B.M., CAO F., ZHOU Y., Krishnasamy A., Biswas K.H., Ravasio A., Chen Z., Wang Y., Kawauchi K., Jones G.E. and Sheetz M.P., Integrin-beta3 clusters recruit clathrin-mediated endocytic machinery in the absence of traction force, Nature Communications. 2015, 6: 8672. |
| ZHANG J., Jia L.J., LIN W., Yip Y.L., Tsang C.M., Zhou Y., Zhu D., Deng W. and Tsao G.S.W., Significance of Epstein-Barr virus encoded Latent Membrane Protein 1-Induced mTOR Signaling in Nasopharyngeal Cells, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| ZHOU Y., Dynamics of Epstein-Barr virus episomes in infected epithelial cells, PhD Thesis, The University of Hong Kong. 2016. |
| Researcher : ZHU D |
| List of Research Outputs |
| ZHANG J., Lau M.Y., ZHU D. and Tsao G.S.W., Functional Study of Epstein-Barr virus Encoded Latent Membrane Protein 1 (LMP1)-Induced mTOR Activation in Nasopharyngeal Carcinoma Cell, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| ZHANG J., Jia L.J., LIN W., Yip Y.L., Tsang C.M., Zhou Y., Zhu D., Deng W. and Tsao G.S.W., Significance of Epstein-Barr virus encoded Latent Membrane Protein 1-Induced mTOR Signaling in Nasopharyngeal Cells, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| ZHU D., ZHANG J., Deng W., Yip Y.L., Lung H.L., Tsang C.M., Law W.T., Yang J., Lau M.Y., Lung M.L., Cheung A. and Tsao G.S.W., Significance of NF-kB activation in immortalization of nasopharyngeal epithelial cells., Int. J. Cancer. 2015. |
| Researcher : ZHU S |
| List of Research Outputs |
| CHEN X., ZHU S., XU W. and Chen J., Regional Disturbances Around the F508 Residues Exhibited Various Impacts on The function of The Cystic Fibrosis Transmembrane Conductance Regulator, ATP-binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases. 2016. |
| CHEN X., ZHU S., XU W. and Chen J., Regional Disturbances Around the F508 Residues Exhibited Various Impacts on The function of The Cystic Fibrosis Transmembrane Conductance Regulator, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| ZHU S. and Chen J., Bacterial killing of cultured pig tracheal epithelia was not altered by HCO3−-free medium, American Thoracic Society (ATS) 2016 International Conference. 2016. |
| ZHU S., XU W., Li N.F. and Chen J., Roles of bicarbonate ion in ion transport and bacterial killing of cultured pig tracheal epithelia, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Researcher : ZHU Y |
| List of Research Outputs |
| TANG X., CAO T., ZHU Y., ZHANG L., CHEN J., Guan X. and Huang J., A positive feedback loop between PIM2 and TNFα contributes to hepatocellular carcinoma tumorigenesis and progression, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Researcher : Zhang S |
| List of Research Outputs |
| CHAUDHARY V., ZHANG S., Yuen K.S., LI D., Kok K.H., LIANG M. and Jin D., Opposite effect of severe fever-with-thrombocytopenia syndrome virus NSs protein on type I and type II interferon signaling, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| Wong H.L.X., Jin G., Cao R., Zhang S., Cao Y. and Zhou Z., MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis., Nature Communication. 2016, 10824. |
| Researcher : Zhang Z |
| List of Research Outputs |
| ZHANG Z., Shea Y.F., Chu L.W. and Song Y., Circulating MicroRNAs in Plasma as Novel Biomarkers for Alzheimer’s Disease, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| Zhang Z., Circulating MicroRNAs in Plasma as Novel Biomarkers of Alzheimer’s Disease, MMedSc Dissertation, The University of Hong Kong. 2015. |
| Zhang Z., Li Y., Ng C.T. and Song Y., Inflammation in Alzheimer's Disease and Molecular Genetics: Recent Update, Arch Immunol Ther Exp (Warsz). 2015. |
| Researcher : Zhou L |
| List of Research Outputs |
| VIRWANI P.D., Zhou L., Wang Y. and Chung S.K., Role of Exchange Protein Directly Activated by cAMP 1 & 2 (Epac1 &Epac2) in Inflammatory Pain, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| VIRWANI P.D., Zhou L., Wang Y. and Chung S.K., Role of Exchange Protein Directly Activated by cAMP 1 & 2 (Epac1 &Epac2) in Inflammatory Pain, Neuroscience Symposium 2016 & Annual Scientific Conference of the Hong Kong Society of Neurosciences. 2016. |
| VIRWANI P.D., Zhou L., Wang Y. and Chung S.K., Role of Exchange Protein Directly Activated by cAMP 1 & 2 (Epac1& Epac2) in Inflammatory Pain, 11th International Symposium on Healthy Aging. 2016. |
| Researcher : Zhou Y |
| List of Research Outputs |
| Li S.K., TANG H.C., Lau P.Y., Zhou Y. and Ching Y.P., HBx targets centrosomal protein TAX1BP2 to promote genomic instability., Cell Symposium – Human Genomics. 2015. |
| Li S.K., TANG H.C., Lau P.Y., Zhou Y. and Ching Y.P., HBx targets centrosomal protein TAX1BP2 to promote genomic instability, In: Genome Institute of Singapore, A*Star, Cell Symposium - Human Genomic, Singapore. 2015. |
| Xu Y.M., Wu D.D., Zheng W., Yu F.Y., Yang F., Yao Y., Zhou Y., Ching Y.P. and Lau T.Y., Proteome profiling of cadmium-induced apoptosis by antibody array analyses in human bronchial epithelial cells., Oncotarget. Impact Journals, 2015, 7: 6146-6158. |
| Yu C., Rafiq N.B.M., CAO F., ZHOU Y., Krishnasamy A., Biswas K.H., Ravasio A., Chen Z., Wang Y., Kawauchi K., Jones G.E. and Sheetz M.P., Integrin-beta3 clusters recruit clathrin-mediated endocytic machinery in the absence of traction force, Nature Communications. 2015, 6: 8672. |
| ZHANG J., Jia L.J., LIN W., Yip Y.L., Tsang C.M., Zhou Y., Zhu D., Deng W. and Tsao G.S.W., Significance of Epstein-Barr virus encoded Latent Membrane Protein 1-Induced mTOR Signaling in Nasopharyngeal Cells, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| ZHOU Y., Dynamics of Epstein-Barr virus episomes in infected epithelial cells, PhD Thesis, The University of Hong Kong. 2016. |
| Researcher : Zhou Z |
| Project Title: | Understanding the regulation of MT1-MMP activity in tumorigenesis |
| Investigator(s): | Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | Matching Fund for NSFC Young Researcher Award |
| Start Date: | 05/2006 |
| Project Title: | Screening anti-ageing substances in small chemical library using premature ageing animals |
| Investigator(s): | Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 09/2007 |
| Project Title: | Stem Cells and the Key signaling Pathways in Bone Aging and Regeneration |
| Investigator(s): | Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | Matching Fund for National Key Basic Research Development Scheme (973 Projects) |
| Start Date: | 03/2011 |
| Project Title: | Stem Cell Strategy for Nervous System Disorders |
| Investigator(s): | Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | Theme-based Research Scheme |
| Start Date: | 09/2012 |
| Project Title: | MT1-MMP regulates neural stem cells self-renewal and differentiation via Notch signaling |
| Investigator(s): | Zhou Z, Osorio Da Silva LA |
| Department: | Biochemistry |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2013 |
| Project Title: | MT1-MMP-mediated ADAM15 shedding in angiogenesis |
| Investigator(s): | Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2013 |
| Project Title: | Chromatin remodeling in laminopathy-based progeria |
| Investigator(s): | Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 07/2013 |
| Project Title: | Interplay between ADAM15 and MT1-MMP in FGF2-induced angiogenesis |
| Investigator(s): | Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2013 |
| Project Title: | Regulation of Gli Signaling and Basal Cell Carcinoma by UHRF1 |
| Investigator(s): | Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 02/2014 |
| Project Title: | Regulation of heterochromatin remodeling in DNA repair and aging |
| Investigator(s): | Zhou Z, Hao Q, Chu IK |
| Department: | Biochemistry |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 02/2014 |
| Project Title: | Outstanding Researcher Award 2013-14 |
| Investigator(s): | Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | Outstanding Researcher Award |
| Start Date: | 12/2014 |
| Project Title: | Lamin A in Chromatin Dynamics and Aging |
| Investigator(s): | Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | Croucher Senior Research Fellowships in Natural Sciences, Technology and Medicine |
| Start Date: | 01/2016 |
| Project Title: | SIRT6 in bone marrow stromal cell potency and the development of osteoporosis |
| Investigator(s): | Zhou Z |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2016 |
| List of Research Outputs |
| CHU T.L., Tsang K.Y., Zhou Z. and Cheah K.S.E., The role of MMP14 in lineage progression of hypertrophic chondrocytes, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| GHOSH S., Liu B., Wang Y., Hao Q. and Zhou Z., Lamin A Is an Endogenous SIRT6 Activator and Promotes SIRT6-Mediated DNA Repair, Cell Reports. 2015, 13: 1396-1406. |
| IEONG I.L., GHOSH S. and Zhou Z., Post-translational modifications of KAP1 and its biological relevance, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| Li H., Wang Y., Zhang L., Lu H., Zhou Z., Wei L. and Yang P., Facile synthesis of novel magnetic silica nanoparticles functionalized with layer-by-layer detonation nanodiamonds for secretome study., In: Duncan Graham, Analyst. Royal Society of Chemistry, 2015, 140 (23): 7886-7895. |
| McCormick M., Delaney J., Tsuchiya M., Tsuchiyama S., Shemorry A., Sim S., Chau A., Ahmed U., CARR D., Murakami C., Schleit J., Sutphin G., Wasko B., Bennett C., Wang A., Olsen B., Beyer R., Bammler T., Prunkard D., Johnson S., Pennypacker J., An E., Anies A., Castanza A., Choi E., Dang N., Enerio S., Fletcher M., Fox L., Goswami S., Higgins S., Holmberg M., Hu D., Hui J., Jelic M., Jeong K., Johnston E., Kerr E., Kim J., Kim D., Kirkland K., Klum S., Kotireddy S., Liao E., Lim M., Lin M., Lo W., Lockshon D., Miller H., Moller R., Muller B., Oakes J., Pak D., Peng Z., Pham K., Pollard T., Pradeep P., Pruett D., Rai D., Robison B., Rodriguez A., Ros B., Sage M., Singh M., Smith E., Snead K., Solanky A., Spector B., Steffen K., Tchao B., Ting M., Vander Wender H., Wang D., Welton K., Westman E., Brem R., Liu X., Suh Y., Zhou Z., Kaeberlain M. and Kennedy B., A Comprehensive Analysis of Replicative Lifespan in 4,698 Single-Gene Deletion Strains Uncovers Conserved Mechanisms of Aging, Cell Metabolism. 2015, 22: 1-12. |
| Osorio Da Silva L.A., Long F.E.I., Wu X.U.E.W.E.I. and Zhou Z., ISM1 plays a pro-tumorigenic role in breast cancer, Croucher Summer Course in Cancer Biology 2015. |
| Wong H.L.X., Jin G., Cao R., Zhang S., Cao Y. and Zhou Z., MT1-MMP sheds LYVE-1 on lymphatic endothelial cells and suppresses VEGF-C production to inhibit lymphangiogenesis., Nature Communication. 2016, 10824. |
| XIONG X., JUNG H., GOMBAR S., PARK J., ZHANG C., ZHENG H., LI J., KAEBERLEIN M., KENNEDY B., Zhou Z., LIU X. and SUH Y., MicroRNA transcriptome analysis identifies miR-365 as a novel negative regulator of cell proliferation in Zmpste24-deficient mouse embryonic fibroblasts, In: Jan Vijg, Mutation Research. Elservier, 2015, 777: 69-78. |
| Zhou Z., Critical role for Lamin A in regulating SIRT1/6 activities and stem cell potency, The Progeria Research Foundation 8th International Scientific Workshop. Boston, USA. Boston, USA, 2016. |
| Zhou Z., Lamin A is an endogenous activator of SIRT6 deacetylase , COLD SPRING HARBOR ASIA CONFERENCES Molecular Basis of Aging and Disease . 2015. |
| Zhou Z., Nuclear lamin A in chromatin remodeling, DNA damage repair and aging, 45th Annual Conference of the American Aging Association. Seattle, USA. 2016. |
| Zhou Z., Nuclear lamin A in chromatin remodeling, DNA damage repair and aging, International conference of the Korean Society for Gerontology. 2016. |
| Researcher : Zhu D |
| List of Research Outputs |
| ZHANG J., Lau M.Y., ZHU D. and Tsao G.S.W., Functional Study of Epstein-Barr virus Encoded Latent Membrane Protein 1 (LMP1)-Induced mTOR Activation in Nasopharyngeal Carcinoma Cell, 20th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine of The University of Hong Kong. 2015. |
| ZHANG J., Jia L.J., LIN W., Yip Y.L., Tsang C.M., Zhou Y., Zhu D., Deng W. and Tsao G.S.W., Significance of Epstein-Barr virus encoded Latent Membrane Protein 1-Induced mTOR Signaling in Nasopharyngeal Cells, Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2016. |
| ZHU D., ZHANG J., Deng W., Yip Y.L., Lung H.L., Tsang C.M., Law W.T., Yang J., Lau M.Y., Lung M.L., Cheung A. and Tsao G.S.W., Significance of NF-kB activation in immortalization of nasopharyngeal epithelial cells., Int. J. Cancer. 2015. |