DEPT OF BIOCHEMISTRY
| Researcher : AO KL |
| List of Research Outputs |
| Lui E.L.H., AO K.L., Li L., KHONG M.L. and Tanner J.A., Inorganic polyphosphate triggers upregulation of interleukin 11 in human osteoblast-like SaOS-2 cells, Biochemical and Biophysical Research Communications. 2016, 479: 766-771. |
| Researcher : Bao S |
| Project Title: | Prioritizing genes from runs of homozygosity associated with Alzheimer's disease by combined analysis of rare variants and gene networks |
| Investigator(s): | Bao S, Song Y, Zhou X |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 04/2015 |
| Completion Date: | 09/2016 |
| Researcher : Chan D |
| Project Title: | Genome-wide identification and functional studies of genetic risk factors for low back pain and intervertebral disc degeneration |
| Investigator(s): | Chan D |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | AOSpine International - General Award |
| Start Date: | 08/2007 |
| Project Title: | Research Output Prize (Li Ka Shing Faculty of Medicine) |
| Investigator(s): | Chan D |
| Department: | Biochemistry |
| Source(s) of Funding: | Research Output Prize (in Faculty) |
| Start Date: | 12/2010 |
| Project Title: | Interplay between ER stress and hypoxic stress in the regulation of chondrocyte differentiation |
| Investigator(s): | Chan D, Cheah KSE |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2012 |
| Project Title: | Integrative Approaches to Understanding Disorders of the Skeleton |
| Investigator(s): | Chan D |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Croucher Advanced Study Institute |
| Start Date: | 12/2013 |
| Project Title: | Progenitor cells in the formation and repair of articular cartilage |
| Investigator(s): | Chan D, Cheah KSE, Chan BP |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Project Title: | Mechanisms of energy management in hypertrophic chondrocyte adaptation to ER Stress |
| Investigator(s): | Chan D, Chan BP, Cheah KSE |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Cellular changes in spinal curvature from FGFR3 mutations and response to drug treatment |
| Investigator(s): | Chan D, To MKT |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | France/Hong Kong Joint Research Scheme - Travel Grants |
| Start Date: | 01/2016 |
| Project Title: | IHH regulating CDO/GAS1 function in synovial joint formation |
| Investigator(s): | Chan D, Cheah KSE |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2017 |
| List of Research Outputs |
| Rajasekaran S., Kanna R.M., Reddy R.R., Natesan S., Raveendran M., Cheung K.M.C., Chan D., Kao P.Y.P., Yee A. and Shetty A.P., How Reliable Are the Reported Genetic Associations in Disc Degeneration?, SPINE. 2016, 41: 1649-1660. |
| Researcher : Chan D. |
| Project Title: | Genome-wide identification and functional studies of genetic risk factors for low back pain and intervertebral disc degeneration |
| Investigator(s): | Chan D |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | AOSpine International - General Award |
| Start Date: | 08/2007 |
| Project Title: | Research Output Prize (Li Ka Shing Faculty of Medicine) |
| Investigator(s): | Chan D |
| Department: | Biochemistry |
| Source(s) of Funding: | Research Output Prize (in Faculty) |
| Start Date: | 12/2010 |
| Project Title: | Interplay between ER stress and hypoxic stress in the regulation of chondrocyte differentiation |
| Investigator(s): | Chan D, Cheah KSE |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2012 |
| Project Title: | Integrative Approaches to Understanding Disorders of the Skeleton |
| Investigator(s): | Chan D |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Croucher Advanced Study Institute |
| Start Date: | 12/2013 |
| Project Title: | Progenitor cells in the formation and repair of articular cartilage |
| Investigator(s): | Chan D, Cheah KSE, Chan BP |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Project Title: | Mechanisms of energy management in hypertrophic chondrocyte adaptation to ER Stress |
| Investigator(s): | Chan D, Chan BP, Cheah KSE |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Cellular changes in spinal curvature from FGFR3 mutations and response to drug treatment |
| Investigator(s): | Chan D, To MKT |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | France/Hong Kong Joint Research Scheme - Travel Grants |
| Start Date: | 01/2016 |
| Project Title: | IHH regulating CDO/GAS1 function in synovial joint formation |
| Investigator(s): | Chan D, Cheah KSE |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2017 |
| List of Research Outputs |
| Researcher : Chan JKM |
| Project Title: | Establishment of novel approaches to the study of the role of histone post-translational modifications in vivo |
| Investigator(s): | Chan KMJ |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2014 |
| Project Title: | Epigenetics, Chromatin & Transcription; Epigenetics / Histone mutations in Human Disease |
| Investigator(s): | Chan KMJ |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2014 |
| Project Title: | Functional analysis of the role of Mcm3 in epigenetic gene silencing |
| Investigator(s): | Chan KMJ |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Researcher : Cheah K.S.E. |
| Project Title: | Defining the role of the transcription factor Sox9 in skeletal development by tissue-specific gene inactivation |
| Investigator(s): | Cheah KSE |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | UK/Hong Kong Joint Research Scheme |
| Start Date: | 02/1998 |
| Project Title: | 4th Pan-Pacific Connective Tissues Societies Symposium Abnormal Regulation of Cartilage and Bone Growth in Transgenic Mice Expressing a Collagen X SMCD Mution |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/1999 |
| Project Title: | Human Genome Meeting 2001 Genomic Analysis of the Mutant Locus in the Novel Transgenic Mouse Mutant, Yellow Submarine (ysb) |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2001 |
| Project Title: | 67th Cold Spring Harbor Symposium on Quantitative Biology - The Cardiovascular System An Essential Role for Type IIA Procollagen in Heart Development |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2002 |
| Project Title: | 1st Annual Meeting of the American Society for Matrix Biology Type IIA Procollagen is Essential for Proper Heart Development |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2002 |
| Project Title: | The Gordon Research Conference on Cartilage Biology and Pathology Chondrocytes Survive ER Stress Caused by Unfolded Proteins and Differentiation is Re-programmed |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2005 |
| Project Title: | 11th Human Genome Meeting Procollagen IIA Facilitates BMP Signaling in Heart Development |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2006 |
| Project Title: | Cold Spring Harbor Laboratory Meeting on Mouse Molecular Genetics Insight into the Molecular Pathogenesis of Campomelic Dysplasia Received By A Conditional SOX9 Mutant Mouse Model |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2006 |
| Project Title: | Role of Sox2 in the stemness of dermal precursors |
| Investigator(s): | Cheah KSE |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 03/2010 |
| Project Title: | Functional analyses of how genomic variation affects personal risk for degenerative skeletal disorders |
| Investigator(s): | Cheah KSE, Chan BP, Chan D, Cheung KMC, Jin D, Lian Q, Luk KDK, Sham PC, Zhang MQ, Cherny SS, Huang J, Ng RK, Samartzis D, Song Y, Wang JJ |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Theme-based Research Scheme |
| Start Date: | 01/2013 |
| Project Title: | Genetic analyses of the roles of Sox2 and Sox18 in hair follicle development |
| Investigator(s): | Cheah KSE |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2013 |
| Completion Date: | 01/2018 |
| Project Title: | Development and Reproduction |
| Investigator(s): | Cheah KSE, Ng EHY, Wu EX |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Funding for Strategic Research Theme |
| Start Date: | 06/2013 |
| Project Title: | Identifying critical transitions and gene regulatory networks controlling phases of chondrocyte differentiation in the growth plate |
| Investigator(s): | Cheah KSE, Wang JJ, Chan D, Ng RK |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2014 |
| Project Title: | Mechanistic insights into the genesis and physiological role of hypertrophic chondrocyte-derived osteoblasts |
| Investigator(s): | Cheah KSE, Chan D |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Project Title: | Craniofacial Morphogenesis & Tissue Regeneration; Transcriptional control of sensory progenitor specification in the inner ear |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 03/2014 |
| Project Title: | Mechanisms controlling determination of sensory versus non-sensory fate in inner ear development |
| Investigator(s): | Cheah KSE, Wong YME, Jin D |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2014 |
| Project Title: | Global Spine Congress 2015; The changing RNAome of the developing nucleus pulposus of the intervertebral disc - implications for Intervertebral Disc Disease |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2015 |
| Project Title: | Gordon Research Conference on Bones and Teeth; Dissecting the transition from hypertrophic chondrocyte to osteoblast in skeletal development and growth |
| Investigator(s): | Cheah KSE |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 02/2016 |
| Project Title: | Gordon Research Conference - 2017 Neural Crest & Cranial Placodes; Impact of Sox2 dosage on sensory neurogenesis and prosensory versus non-sensory cell fate in the inner ear |
| Investigator(s): | Cheah KSE |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 02/2017 |
| Researcher : Cheah KSE |
| Project Title: | Defining the role of the transcription factor Sox9 in skeletal development by tissue-specific gene inactivation |
| Investigator(s): | Cheah KSE |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | UK/Hong Kong Joint Research Scheme |
| Start Date: | 02/1998 |
| Project Title: | 4th Pan-Pacific Connective Tissues Societies Symposium Abnormal Regulation of Cartilage and Bone Growth in Transgenic Mice Expressing a Collagen X SMCD Mution |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/1999 |
| Project Title: | Human Genome Meeting 2001 Genomic Analysis of the Mutant Locus in the Novel Transgenic Mouse Mutant, Yellow Submarine (ysb) |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2001 |
| Project Title: | 67th Cold Spring Harbor Symposium on Quantitative Biology - The Cardiovascular System An Essential Role for Type IIA Procollagen in Heart Development |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2002 |
| Project Title: | 1st Annual Meeting of the American Society for Matrix Biology Type IIA Procollagen is Essential for Proper Heart Development |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2002 |
| Project Title: | The Gordon Research Conference on Cartilage Biology and Pathology Chondrocytes Survive ER Stress Caused by Unfolded Proteins and Differentiation is Re-programmed |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2005 |
| Project Title: | 11th Human Genome Meeting Procollagen IIA Facilitates BMP Signaling in Heart Development |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2006 |
| Project Title: | Cold Spring Harbor Laboratory Meeting on Mouse Molecular Genetics Insight into the Molecular Pathogenesis of Campomelic Dysplasia Received By A Conditional SOX9 Mutant Mouse Model |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2006 |
| Project Title: | Role of Sox2 in the stemness of dermal precursors |
| Investigator(s): | Cheah KSE |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 03/2010 |
| Project Title: | Functional analyses of how genomic variation affects personal risk for degenerative skeletal disorders |
| Investigator(s): | Cheah KSE, Chan BP, Chan D, Cheung KMC, Jin D, Lian Q, Luk KDK, Sham PC, Zhang MQ, Cherny SS, Huang J, Ng RK, Samartzis D, Song Y, Wang JJ |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Theme-based Research Scheme |
| Start Date: | 01/2013 |
| Project Title: | Genetic analyses of the roles of Sox2 and Sox18 in hair follicle development |
| Investigator(s): | Cheah KSE |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2013 |
| Completion Date: | 01/2018 |
| Project Title: | Development and Reproduction |
| Investigator(s): | Cheah KSE, Ng EHY, Wu EX |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Funding for Strategic Research Theme |
| Start Date: | 06/2013 |
| Project Title: | Identifying critical transitions and gene regulatory networks controlling phases of chondrocyte differentiation in the growth plate |
| Investigator(s): | Cheah KSE, Wang JJ, Chan D, Ng RK |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2014 |
| Project Title: | Mechanistic insights into the genesis and physiological role of hypertrophic chondrocyte-derived osteoblasts |
| Investigator(s): | Cheah KSE, Chan D |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Project Title: | Craniofacial Morphogenesis & Tissue Regeneration; Transcriptional control of sensory progenitor specification in the inner ear |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 03/2014 |
| Project Title: | Mechanisms controlling determination of sensory versus non-sensory fate in inner ear development |
| Investigator(s): | Cheah KSE, Wong YME, Jin D |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2014 |
| Project Title: | Global Spine Congress 2015; The changing RNAome of the developing nucleus pulposus of the intervertebral disc - implications for Intervertebral Disc Disease |
| Investigator(s): | Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2015 |
| Project Title: | Gordon Research Conference on Bones and Teeth; Dissecting the transition from hypertrophic chondrocyte to osteoblast in skeletal development and growth |
| Investigator(s): | Cheah KSE |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 02/2016 |
| Project Title: | Gordon Research Conference - 2017 Neural Crest & Cranial Placodes; Impact of Sox2 dosage on sensory neurogenesis and prosensory versus non-sensory cell fate in the inner ear |
| Investigator(s): | Cheah KSE |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 02/2017 |
| Researcher : Cheng LYL |
| Project Title: | A concordance study of the importance of autosomal short tandem repeat (STR) and Y-chromosome STR in the Chinese community |
| Investigator(s): | Cheng LYL, Tan-Un KC |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2002 |
| Researcher : Fu C |
| Project Title: | Systematic investigation of the roles of mitotic kinesins in spindle dynamics |
| Investigator(s): | Fu C |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2013 |
| Project Title: | Molecular mechanisms of nuclear congression |
| Investigator(s): | Fu C |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2016 |
| List of Research Outputs |
| ZHU Q., Zhang F., Liu A...P., Qian J., Fu C. and Lin Y., Shape transformation of the nuclear envelope during closed mitosis. Biophysical Journal., Biophysical Journal. 2016, 111: 2309-2316. |
| Researcher : Guo S |
| Project Title: | 47th Annual Meeting for the Japanese Society of Developmental Biologists; Lack of β1 integrin results in defective notochord morphogenesis with impaired convergent extension in the mouse |
| Investigator(s): | Guo S |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2014 |
| Researcher : Huang J |
| Project Title: | RNA-DNA hybrid oligonucleotide mediated site-specific repair and gene therapy |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Matching Fund for Hi-Tech Research and Development Program of China (863 Projects) |
| Start Date: | 01/2003 |
| Project Title: | Development of a Pan-organism Riboregulator Device |
| Investigator(s): | Huang J, Jin Y |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Innovation and Technology Support Programme (Tier 3) |
| Start Date: | 11/2009 |
| Project Title: | Development of a Pan-organism Riboregulator Device |
| Investigator(s): | Huang J |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 12/2009 |
| Project Title: | Outstanding Research Student Supervisor Award 2011-12 |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Outstanding Research Student Supervisor Award |
| Start Date: | 01/2013 |
| Project Title: | Protein Trafficking: Mechanism and Diseases |
| Investigator(s): | Huang J |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 04/2013 |
| Project Title: | Non-canonical role of Kif5b in clathrin uncoating and the endocytic regulation of muscarinic acetylcholine receptors |
| Investigator(s): | Huang J, Ni Y |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2013 |
| Project Title: | A Generic Mechanism for Pattern Formation: From Theoretical Physics To Synthetic Biology |
| Investigator(s): | Huang J |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | France/Hong Kong Joint Research Scheme - Travel Grants |
| Start Date: | 01/2014 |
| Completion Date: | 12/2016 |
| Project Title: | Bridge the gap in nerve tissue injury to promote axonal regeneration with fabrication of a bioactive nanofibrous conduit |
| Investigator(s): | Huang J, Wu W |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 07/2014 |
| Project Title: | Pattern formation by bacteria: from theoretical physics to synthetic biology |
| Investigator(s): | Huang J |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | ANR / RGC Joint Research Scheme |
| Start Date: | 01/2015 |
| Project Title: | A feasibility study on the inhibition of Staphylococcus aureus infection using AdsA specific antibodies |
| Investigator(s): | Huang J, Chen Z |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2015 |
| Project Title: | Development of antibodies against Staphylococcus aureus infection |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Translational and Applied Research |
| Start Date: | 06/2015 |
| Completion Date: | 12/2016 |
| Project Title: | Doris Zimmern HKU-Cambridge Hughes Hall Fellowships 2015-16 |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Doris Zimmern HKU-Cambridge Hughes Hall Fellowships |
| Start Date: | 09/2015 |
| Project Title: | Characterization of the interaction between Kif5b and NMDAR in ischemic provoked neurodegeneration |
| Investigator(s): | Huang J, Sze KH |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2016 |
| Project Title: | Outstanding Researcher Award 2014-15 |
| Investigator(s): | Huang J |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Outstanding Researcher Award |
| Start Date: | 02/2016 |
| Project Title: | Salmonella-induced host innate immunity against cancer metastasis |
| Investigator(s): | Huang J |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2016 |
| Project Title: | The International Conference on Vaccines Research & Development (Vaccines R&D-2016) ; A novel vaccine preventing Staphylococcus aureus infection |
| Investigator(s): | Huang J |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2016 |
| Completion Date: | 11/2016 |
| Project Title: | Investigation of the interaction between kinesin heavy chain and kinesin light chain |
| Investigator(s): | Huang J |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2017 |
| Project Title: | Development of virus-like particle (VLP)-based vaccine against Streptococcus pneumoniae infection |
| Investigator(s): | Huang J |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Translational and Applied Research |
| Start Date: | 06/2017 |
| List of Research Outputs |
| Li C., Yu B., Shi L., Geng W., Lin Q., Ling C., Yang M., Ng K.T.P., Huang J. and Man K., 'Obligate' anaerobic Salmonella strain YB1 suppresses liver tumor growth and metastasis in nude mice, Oncology Letters. 2016, 13(1): 177-183. |
| Researcher : Huang J. |
| Project Title: | RNA-DNA hybrid oligonucleotide mediated site-specific repair and gene therapy |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Matching Fund for Hi-Tech Research and Development Program of China (863 Projects) |
| Start Date: | 01/2003 |
| Project Title: | Development of a Pan-organism Riboregulator Device |
| Investigator(s): | Huang J, Jin Y |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Innovation and Technology Support Programme (Tier 3) |
| Start Date: | 11/2009 |
| Project Title: | Development of a Pan-organism Riboregulator Device |
| Investigator(s): | Huang J |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 12/2009 |
| Project Title: | Outstanding Research Student Supervisor Award 2011-12 |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Outstanding Research Student Supervisor Award |
| Start Date: | 01/2013 |
| Project Title: | Protein Trafficking: Mechanism and Diseases |
| Investigator(s): | Huang J |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 04/2013 |
| Project Title: | Non-canonical role of Kif5b in clathrin uncoating and the endocytic regulation of muscarinic acetylcholine receptors |
| Investigator(s): | Huang J, Ni Y |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2013 |
| Project Title: | A Generic Mechanism for Pattern Formation: From Theoretical Physics To Synthetic Biology |
| Investigator(s): | Huang J |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | France/Hong Kong Joint Research Scheme - Travel Grants |
| Start Date: | 01/2014 |
| Completion Date: | 12/2016 |
| Project Title: | Bridge the gap in nerve tissue injury to promote axonal regeneration with fabrication of a bioactive nanofibrous conduit |
| Investigator(s): | Huang J, Wu W |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 07/2014 |
| Project Title: | Pattern formation by bacteria: from theoretical physics to synthetic biology |
| Investigator(s): | Huang J |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | ANR / RGC Joint Research Scheme |
| Start Date: | 01/2015 |
| Project Title: | A feasibility study on the inhibition of Staphylococcus aureus infection using AdsA specific antibodies |
| Investigator(s): | Huang J, Chen Z |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2015 |
| Project Title: | Development of antibodies against Staphylococcus aureus infection |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Translational and Applied Research |
| Start Date: | 06/2015 |
| Completion Date: | 12/2016 |
| Project Title: | Doris Zimmern HKU-Cambridge Hughes Hall Fellowships 2015-16 |
| Investigator(s): | Huang J |
| Department: | Biochemistry |
| Source(s) of Funding: | Doris Zimmern HKU-Cambridge Hughes Hall Fellowships |
| Start Date: | 09/2015 |
| Project Title: | Characterization of the interaction between Kif5b and NMDAR in ischemic provoked neurodegeneration |
| Investigator(s): | Huang J, Sze KH |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2016 |
| Project Title: | Outstanding Researcher Award 2014-15 |
| Investigator(s): | Huang J |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Outstanding Researcher Award |
| Start Date: | 02/2016 |
| Project Title: | Salmonella-induced host innate immunity against cancer metastasis |
| Investigator(s): | Huang J |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2016 |
| Project Title: | The International Conference on Vaccines Research & Development (Vaccines R&D-2016) ; A novel vaccine preventing Staphylococcus aureus infection |
| Investigator(s): | Huang J |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2016 |
| Completion Date: | 11/2016 |
| Project Title: | Investigation of the interaction between kinesin heavy chain and kinesin light chain |
| Investigator(s): | Huang J |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2017 |
| Project Title: | Development of virus-like particle (VLP)-based vaccine against Streptococcus pneumoniae infection |
| Investigator(s): | Huang J |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Translational and Applied Research |
| Start Date: | 06/2017 |
| List of Research Outputs |
| Researcher : Jin D |
| Project Title: | Mitotic checkpoint and genomic stability in ovarian cancer |
| Investigator(s): | Jin D |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | National Institutes of Health, US Department of Health and Human Services - General Award |
| Start Date: | 09/2002 |
| Project Title: | Outstanding Researcher Award 2007-2008 |
| Investigator(s): | Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | Outstanding Researcher Award |
| Start Date: | 10/2008 |
| Project Title: | 4th Intracellular Proteolysis Meeting on Ubiquitin-proteasome System, Dynamics and Targeting REV7-mediated polyubiquitination and degradation of human REV1 |
| Investigator(s): | Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2009 |
| Project Title: | Knockdown of miR-BART5 in Epstein-Barr Virus-infected Cells by RNA Decoys Delivered through Novel Adenoviral Vectors: a New Paradigm for Cancer Therapy |
| Investigator(s): | Jin D, Kok KH, Lei T |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Innovation and Technology Support Programme (Tier 3) |
| Start Date: | 01/2010 |
| Project Title: | Knockdown of miR-BART5 in Epstein-Barr Virus-infected Cells by RNA Decoys Delivered through Novel Adenoviral Vectors: a New Paradigm for Cancer Therapy |
| Investigator(s): | Jin D |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 01/2010 |
| Project Title: | Knockdown of miR-BART5 in Epstein-Barr Virus-infected Cells by RNA Decoys Delivered through Novel Adenoviral Vectors: a New Paradigm for Cancer Therapy |
| Investigator(s): | Jin D |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 01/2010 |
| Project Title: | Mapping of peptide sequence in swine-origin H1N1 influenza virus hemagglutinin associated with the induction of anti-ganglioside antibodies implicated in Guillain-Barre syndrome: a pilot study |
| Investigator(s): | Jin D, Zheng B |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 01/2011 |
| Project Title: | Molecular dissection of NSs virulence factor in severe fever with thrombocytopenia syndrome virus (SFTSV), a novel bunyavirus identified in China |
| Investigator(s): | Jin D, Kok KH |
| Department: | Biochemistry |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2013 |
| Completion Date: | 12/2016 |
| Project Title: | Roles of CRTC coactivators in hepatitis B virus X protein-mediated activation of CREB-dependent transcription |
| Investigator(s): | Jin D, Zheng B, Zhou J, Tang HMV |
| Department: | Biochemistry |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2013 |
| Completion Date: | 10/2016 |
| Project Title: | Regulatory roles of SIRT1 deacetylase in hepatitis B virus transcription |
| Investigator(s): | Jin D, Zhou J, Tang HMV |
| Department: | Biochemistry |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2014 |
| Completion Date: | 02/2017 |
| Project Title: | Mechanism of inflammasome activation by SARS coronavirus 3a protein |
| Investigator(s): | Jin D, Zheng B, Tang HMV |
| Department: | Biochemistry |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2014 |
| Completion Date: | 02/2017 |
| Project Title: | Outstanding Research Student Supervisor Award 2013-14 |
| Investigator(s): | Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | Outstanding Research Student Supervisor Award |
| Start Date: | 12/2014 |
| Project Title: | Identification and characterization of human cyclic dinucleotide phosphodiesterases that hydrolyze cGAMP second messenger |
| Investigator(s): | Jin D, Tse H |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Suppression of innate interferon production by Middle East respiratory syndrome coronavirus M protein |
| Investigator(s): | Jin D, Yeung ML |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2015 |
| Project Title: | Identification and characterization of a novel transcript isoform of STING that negatively regulates innate antiviral response |
| Investigator(s): | Jin D, Yang W, Deng J |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2016 |
| Project Title: | Suppression of hepatitis B virus transcription by LKB1 and salt-inducible kinases |
| Investigator(s): | Jin D, Deng J, Kong KY |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2016 |
| Project Title: | Molecular Mechanism of PACT-dependent Innate Antiviral Response |
| Investigator(s): | Jin D, Chan CP, Sham MH, Yeung ML, Yuen KY, Zheng B, Zhou J |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 06/2016 |
| Project Title: | Perturbation of MAVS-dependent antiviral response by PB1-F2 protein of influenza A (H7N9) virus and implications to viral pathogenesis |
| Investigator(s): | Jin D, Chen H, Chan CP |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2016 |
| Project Title: | Frontiers of Retrovirology Conference 2016; Perturbation of innate RNA and DNA sensing by human T-cell leukemia virus type 1 oncoproteins |
| Investigator(s): | Jin D |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2016 |
| Completion Date: | 09/2016 |
| Project Title: | Identification and characterization of MDM2 as an E3 ubiquitin ligase for STAT2 activated by Zika virus NS5 protein |
| Investigator(s): | Jin D, Yuen KS, Wang F |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2017 |
| Project Title: | Roles of BART non-coding RNAs in Epstein-Barr virus infection and oncogenesis (CRF) |
| Investigator(s): | Jin D |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Funding for Strategic Interdisciplinary Research Scheme |
| Start Date: | 06/2017 |
| List of Research Outputs |
| Chan C.M., Chu H., Zhang J., Leung L.H., Sze K.H., Kao R.Y.T., Chik K.K.H., To K.K.W., Chan J.F.W., Chen H., Jin D., Liu L. and Yuen K.Y., Hemagglutinin of influenza A virus binds specifically to cell surface nucleolin and plays a role in virus internalization, Virology. 2016, 494: 78-88. |
| Researcher : Kok KH |
| Project Title: | Identification of a novel splice isoform of TRBP and characterization of its role in microRNA biogenesis |
| Investigator(s): | Kok KH, Wong CM |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2012 |
| Project Title: | Mechanistic study of the roles of PACT in MDA5-mediated innate antiviral immunity |
| Investigator(s): | Kok KH, Chan CP |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2013 |
| Project Title: | Role of PACT in host antiviral defence against influenza A virus |
| Investigator(s): | Kok KH |
| Department: | Biochemistry |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 01/2013 |
| Completion Date: | 10/2016 |
| Project Title: | Suppression of PACT-dependent antiviral response by measles virus V protein |
| Investigator(s): | Kok KH |
| Department: | Microbiology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2015 |
| Project Title: | Functional role of PACT in limiting replication of influenza A virus |
| Investigator(s): | Kok KH |
| Department: | Microbiology |
| Source(s) of Funding: | Early Career Scheme (ECS) |
| Start Date: | 01/2016 |
| Project Title: | Innate immune sensing of rotavirus |
| Investigator(s): | Kok KH |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2016 |
| Project Title: | A novel approach for the identification of N6-methyladenosine (m6A) RNA modification in human and viral mRNA |
| Investigator(s): | Kok KH |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2017 |
| Project Title: | The role of ARRDC3 in the innate immune response to influenza A virus infection |
| Investigator(s): | Kok KH, Chen H |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2017 |
| Project Title: | The 36th Annual Meeting of American Society for Virology; Inhibition of primary interferon production by Measles virus V protein |
| Investigator(s): | Kok KH |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2017 |
| Completion Date: | 06/2017 |
| Researcher : Lam VMS |
| Project Title: | 18th International Congress of Biochemistry and Molecular Biology Beyond the Human Glucose-6-phosphate Dehydrogenase (G6PD) Gene: Protein Structure and Function Analyses |
| Investigator(s): | Lam VMS |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2000 |
| Project Title: | HUGO's Seventh International Human Genome Meeting, HGM2002 Post-Genomic Glucose-6-phosphate Dehydrogenase (G6PD): Different Mechanisms for Enzyme Deficiency from Structural and Kinetic Analyses |
| Investigator(s): | Lam VMS |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2002 |
| Project Title: | 7th International Symposium on Mutations in the Human Genome Multiplex Detection: a Rapid and Reliable Method to Screen Common Variations in the Glucose-6-phosphate Dehydrogenase Gene |
| Investigator(s): | Lam VMS |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2003 |
| Researcher : Lei T |
| Project Title: | A→I editing of Epstein-Barr virus-encoded BART microRNAs and its impact on microRNA biogenesis |
| Investigator(s): | Lei T, Jin D |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2009 |
| Researcher : Liu B |
| Project Title: | Adult stem cell decline accelerates premature ageing in Zmpste24 deficient mice |
| Investigator(s): | Liu B, Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 08/2008 |
| Project Title: | Stem Cells 2009 Oxidative stress-mediated accelerated adult stem cell decline contributes to premature ageing in Zmpste24–/– mice |
| Investigator(s): | Liu B |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2009 |
| Project Title: | Quantitative mass spectrometry-based screening for SIRT1 deacetylating targets |
| Investigator(s): | Liu B, Zhou Z, Chu IK |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2012 |
| Project Title: | Role of Autophagy in Cellular Senescence and Laminopathy-based Premature Ageing |
| Investigator(s): | Liu B |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2013 |
| Researcher : Niu B |
| Project Title: | Whole genome identification of active core promoters, enhancers and insulators in mouse growth plate |
| Investigator(s): | Niu B, Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2010 |
| Researcher : Sham MH |
| Project Title: | International Congress on Differentation and Cell Biology Neural-specific Cis-acting and Trans-acting Regulation of the Mouse Hoxb-3 Gene During Embryogenesis |
| Investigator(s): | Sham MH |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2000 |
| Project Title: | Outstanding Research Student Supervisor Award 2008-2009 |
| Investigator(s): | Sham MH |
| Department: | Biochemistry |
| Source(s) of Funding: | Outstanding Research Student Supervisor Award |
| Start Date: | 12/2009 |
| Project Title: | Visiting Research Professors Scheme 2010-11 |
| Investigator(s): | Sham MH |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Visiting Research Professors Scheme |
| Start Date: | 09/2010 |
| Project Title: | The roles of Suppressor of fused (Sufu) in the maintenance of mammalian neural progenitor cells |
| Investigator(s): | Sham MH |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | The interactions of EyaI and Notch signaling in the branchial epithelia during mammalian craniofacial development |
| Investigator(s): | Sham MH |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2016 |
| Project Title: | Modulation of Notch Signaling by EYA1 in Breast Cancer |
| Investigator(s): | Sham MH |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2016 |
| Project Title: | The roles of N-Myc, Sufu and Gli genes in regulating the dynamic progression of mammalian cochlear hair cell differentiation |
| Investigator(s): | Sham MH |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2017 |
| Researcher : Shi L |
| List of Research Outputs |
| Li C., Yu B., Shi L., Geng W., Lin Q., Ling C., Yang M., Ng K.T.P., Huang J. and Man K., 'Obligate' anaerobic Salmonella strain YB1 suppresses liver tumor growth and metastasis in nude mice, Oncology Letters. 2016, 13(1): 177-183. |
| Researcher : Shum DKY |
| Project Title: | 30th Annual Conference of Society for Neuroscience Effects of Chondroitin Sulfate Supplements on Regeneration of Bridged Sciatic Nerves |
| Investigator(s): | Shum DKY |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2000 |
| Project Title: | 31st Annual Meeting of Society for Neuroscience Expression of Chondroitin 6-sulfotransferase mRNA and the Sulfation Product in Post-crush Sciatic Nerves of Adult Rats |
| Investigator(s): | Shum DKY |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2001 |
| Project Title: | Expression of heparanase in the injured spinal cord |
| Investigator(s): | Shum DKY |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2003 |
| Project Title: | 33rd Annual Conference of the Society for Neuroscience Spatiotemporal Expression of Chondroitin 6-Sulfotransferase (C6ST) In Regeneration of Crush-injured Sciatic Nerves of Adult Rats C6ST Expression in Sciatic Nerve Explant Culture of Adult Rats |
| Investigator(s): | Shum DKY |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2003 |
| Project Title: | Expression of chondroitin sulfotransferases in the injured spinal cord |
| Investigator(s): | Shum DKY |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2004 |
| Project Title: | Proteoglycans in Signaling Heparan Sulfate/Syndecan-1 Modulates the Balance between Proteinase and Anti-Proteinase in Bronchiectasis |
| Investigator(s): | Shum DKY |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2005 |
| Project Title: | From bone marrow stromal cells to Schwann cells – in vitro route to specification and utility in re-myelination therapy |
| Investigator(s): | Shum DKY, Chan YS |
| Department: | Biochemistry |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2012 |
| Researcher : Smith DK |
| Project Title: | Patterns in proteins with unusual flexibility profiles |
| Investigator(s): | Smith DK |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding for New Staff |
| Start Date: | 08/2002 |
| Researcher : Song Y |
| Project Title: | A Randomized Controlled Trial of the Therapeutic Effects of Tai Chi and Mahjong on Older Persons With Cognitive Impairment |
| Investigator(s): | Song Y |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2008 |
| Project Title: | Investigation on Pax6 regulation of neuronal apoptosis in Alzheimer’s disease |
| Investigator(s): | Song Y |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2013 |
| Project Title: | Study of Population Specific Linkage Disequilibrium (LD) Patterns of Human Major Histocompatibility Complex (MHC) Region for Cancers, Infectious and Autoimmunity Diseases in Southern Chinese |
| Investigator(s): | Song Y, Sham PC, Fan Y |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2014 |
| Completion Date: | 07/2017 |
| Project Title: | Modeling host susceptibility to influenza H7N9 virus in inbred mice: a pilot study |
| Investigator(s): | Song Y, Yeung ML, Kok KH |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Commissioned Studies on Emerging Influenza A Viruses with Epidemic Potential |
| Start Date: | 10/2014 |
| Completion Date: | 06/2017 |
| Project Title: | Targeted sequencing to identify of genes on candidate loci causing Adolescent Idiopathic Scoliosis (AIS) |
| Investigator(s): | Song Y, Luk KDK, Chan D, Sham PC, Cheung KMC |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2015 |
| Completion Date: | 03/2017 |
| Project Title: | Study of the pathogenic mechanisms of Hnrnpa1 in congenital heart defects (CHD) |
| Investigator(s): | Song Y, Lian Q, Cheah KSE |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2016 |
| Project Title: | Investigation of the roles of HNRNPA1 in the maintenance of motor neurons |
| Investigator(s): | Song Y, Cheung MCH, Ho WL, Huen MSY |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 03/2016 |
| Project Title: | Alzheimer's Association International Conference (AAIC); A role of PTPN21 in neuron survival and degeneration |
| Investigator(s): | Song Y |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2016 |
| Completion Date: | 07/2016 |
| Project Title: | Mapping a locus on chromosome 17 controlling endoplasmic reticulum stress and defence response in mice |
| Investigator(s): | Song Y, Yeung ML, Bao S |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2017 |
| Researcher : Szeto YY |
| Project Title: | Transcriptional regulation of Aqp3 by Sox9 and Sox9Y440X in the mouse inner ear |
| Investigator(s): | Szeto YY, Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2012 |
| Researcher : Tam JWO |
| Project Title: | 14th Annual San Diego Conference: Nucleic Acid Technologies in Disease Detection Direct Flow-Through Hybridisation Device: An Effective and Lost Cost Apparatus for Rapid DNA Analysis |
| Investigator(s): | Tam JWO |
| Department: | Biochemistry |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/1999 |
| Researcher : Tam V |
| Project Title: | Understanding the role of clusterin in intervertebral disc degeneration |
| Investigator(s): | Tam V, Chan D |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2015 |
| List of Research Outputs |
| Cheung W.H.P., Tam V., Leung V.Y.L., Samartzis D., Cheung K.M.C., Luk K.D.K. and Cheung J.P.Y., The paradoxical relationship between ligamentum flavum hypertrophy and developmental lumbar spinal stenosis., Scoliosis and Spinal Disorders. 2016. |
| Researcher : Tanner J.A. |
| Project Title: | Comparative Characterization of the Two Polyphosphate Kinases of M. tuberculosis |
| Investigator(s): | Tanner JA |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 02/2005 |
| Project Title: | 3-D Printed Aptamer-Enabled Diagnostic Dominoes for Malaria |
| Investigator(s): | Tanner JA |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Completion Date: | 01/2018 |
| Project Title: | Aptamer-mediated Point-of-Care Diagnostics (CRF) |
| Investigator(s): | Tanner JA |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Funding for Incubating Group-based Collaborative Research Projects |
| Start Date: | 01/2015 |
| Completion Date: | 12/2016 |
| Project Title: | DNA origami interfaced with aptamer-mediated molecular recognition for integrated modular diagnostics |
| Investigator(s): | Tanner JA, Watt RM |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | DNA Display SELEX ??a new approach to evolve fluorescent tools to image RNA in living cells |
| Investigator(s): | Tanner JA, Shum HC |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2016 |
| Project Title: | Development of an aptamer-based sensor for monitoring luteinizing hormone pulsatility |
| Investigator(s): | Tanner JA, Li RHW |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2016 |
| Project Title: | Outstanding Young Researcher Award 2015-16 |
| Investigator(s): | Tanner JA |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Outstanding Young Researcher Award |
| Start Date: | 11/2016 |
| Project Title: | Expanding the functional repertoire of nucleic acid aptamers by fluorescence-activated droplet sorting |
| Investigator(s): | Tanner JA, Shum HC |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2017 |
| Project Title: | Using unnatural base pairs from an expanded genetic code to achieve nested chain terminating PCR for applications in highly multiplexed DNA amplification |
| Investigator(s): | Tanner JA, Kinghorn AB |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2017 |
| Project Title: | 5th International Conference on Biosensing Technology; Aptamer-mediated biosensing: from malaria diagnosis to DNA nanostructure dynamics |
| Investigator(s): | Tanner JA |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2017 |
| Completion Date: | 05/2017 |
| Researcher : Tanner JA |
| Project Title: | Comparative Characterization of the Two Polyphosphate Kinases of M. tuberculosis |
| Investigator(s): | Tanner JA |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 02/2005 |
| Project Title: | 3-D Printed Aptamer-Enabled Diagnostic Dominoes for Malaria |
| Investigator(s): | Tanner JA |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Completion Date: | 01/2018 |
| Project Title: | Aptamer-mediated Point-of-Care Diagnostics (CRF) |
| Investigator(s): | Tanner JA |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Funding for Incubating Group-based Collaborative Research Projects |
| Start Date: | 01/2015 |
| Completion Date: | 12/2016 |
| Project Title: | DNA origami interfaced with aptamer-mediated molecular recognition for integrated modular diagnostics |
| Investigator(s): | Tanner JA, Watt RM |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | DNA Display SELEX ??a new approach to evolve fluorescent tools to image RNA in living cells |
| Investigator(s): | Tanner JA, Shum HC |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2016 |
| Project Title: | Development of an aptamer-based sensor for monitoring luteinizing hormone pulsatility |
| Investigator(s): | Tanner JA, Li RHW |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2016 |
| Project Title: | Outstanding Young Researcher Award 2015-16 |
| Investigator(s): | Tanner JA |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Outstanding Young Researcher Award |
| Start Date: | 11/2016 |
| Project Title: | Expanding the functional repertoire of nucleic acid aptamers by fluorescence-activated droplet sorting |
| Investigator(s): | Tanner JA, Shum HC |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2017 |
| Project Title: | Using unnatural base pairs from an expanded genetic code to achieve nested chain terminating PCR for applications in highly multiplexed DNA amplification |
| Investigator(s): | Tanner JA, Kinghorn AB |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2017 |
| Project Title: | 5th International Conference on Biosensing Technology; Aptamer-mediated biosensing: from malaria diagnosis to DNA nanostructure dynamics |
| Investigator(s): | Tanner JA |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2017 |
| Completion Date: | 05/2017 |
| Researcher : Tsang SW |
| Project Title: | Consequences of activation of canonical Wnt signaling pathway in hypertrophic chondrocytes and their descendents in vivo |
| Investigator(s): | Tsang SW, Cheah KSE |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2012 |
| List of Research Outputs |
| CHU T.L., Tsang K.Y., Tsang S.W., Zhou Z. and Cheah K.S.E., MMP14 Regulates Lineage Progression of Hypertrophic Chondrocytes, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016. |
| Researcher : Wang JJ |
| Project Title: | Outstanding Young Researcher Award 2011-12 |
| Investigator(s): | Wang JJ |
| Department: | Biochemistry |
| Source(s) of Funding: | Outstanding Young Researcher Award |
| Start Date: | 01/2013 |
| Project Title: | Understanding the effects of DNA methylation on gene expression - a computational approach |
| Investigator(s): | Wang JJ, Wong MP, Chim JCS |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2015 |
| Researcher : Wong NS |
| Project Title: | Kappa-opioid receptor mediated cellular stress response: the role of Inositol 1,4,5-trisphosphate and diacylglycerol |
| Investigator(s): | Wong NS, Yao KM |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2002 |
| Project Title: | Cellular stress responses in cancer cells with impaired glycogen metabolism |
| Investigator(s): | Wong NS |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2016 |
| Researcher : Yao KM |
| Project Title: | Regulation of Bmi-1 expression by the Forkhead box transcription factor FoxM1 |
| Investigator(s): | Yao KM |
| Department: | Biochemistry |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2007 |
| Project Title: | Investigating the role of FOXM1 in the maintenance of human embryonic stem cell pluripotency and genome stability |
| Investigator(s): | Yao KM, Cheung MCH |
| Department: | Biochemistry |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2012 |
| Project Title: | Elucidating the nuclear function of EPS8/EPS8L2: Crosstalk with FOXM1 and regulation of cancer cell proliferation and migration/invasion |
| Investigator(s): | Yao KM, Chan DW |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2014 |
| Project Title: | Identifying the cognate receptor of secreted PDZD2 |
| Investigator(s): | Yao KM |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2015 |
| Completion Date: | 12/2016 |
| Project Title: | Study of Zinc Finger And BTB Domain Containing 33 (ZBTB33) as putative FOXM1-interacting protein in the regulation of cancer cell proliferation |
| Investigator(s): | Yao KM, Lee CYL |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2017 |
| Researcher : Yu B |
| Project Title: | Virus-like particle (VLP)-based mucosal vaccine for inducing cross-serotype immunity against Streptococcus pneumoniae infection |
| Investigator(s): | Yu B, Huang J, Ho PL |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2017 |
| List of Research Outputs |
| Li C., Yu B., Shi L., Geng W., Lin Q., Ling C., Yang M., Ng K.T.P., Huang J. and Man K., 'Obligate' anaerobic Salmonella strain YB1 suppresses liver tumor growth and metastasis in nude mice, Oncology Letters. 2016, 13(1): 177-183. |
| Researcher : Zhou Z |
| Project Title: | Understanding the regulation of MT1-MMP activity in tumorigenesis |
| Investigator(s): | Zhou Z |
| Department: | Biochemistry |
| Source(s) of Funding: | Matching Fund for NSFC Young Researcher Award |
| Start Date: | 05/2006 |
| Project Title: | Screening anti-ageing substances in small chemical library using premature ageing animals |
| Investigator(s): | Zhou Z |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 09/2007 |
| Project Title: | Stem Cells and the Key signaling Pathways in Bone Aging and Regeneration |
| Investigator(s): | Zhou Z |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Matching Fund for National Key Basic Research Development Scheme (973 Projects) |
| Start Date: | 03/2011 |
| Project Title: | Stem Cell Strategy for Nervous System Disorders |
| Investigator(s): | Zhou Z |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Theme-based Research Scheme |
| Start Date: | 09/2012 |
| Project Title: | MT1-MMP regulates neural stem cells self-renewal and differentiation via Notch signaling |
| Investigator(s): | Zhou Z, Osorio Da Silva LA |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2013 |
| Project Title: | MT1-MMP-mediated ADAM15 shedding in angiogenesis |
| Investigator(s): | Zhou Z |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2013 |
| Project Title: | Interplay between ADAM15 and MT1-MMP in FGF2-induced angiogenesis |
| Investigator(s): | Zhou Z |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2013 |
| Completion Date: | 08/2016 |
| Project Title: | Regulation of Gli Signaling and Basal Cell Carcinoma by UHRF1 |
| Investigator(s): | Zhou Z |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 02/2014 |
| Project Title: | Regulation of heterochromatin remodeling in DNA repair and aging |
| Investigator(s): | Zhou Z, Hao Q, Chu IK |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 02/2014 |
| Project Title: | Outstanding Researcher Award 2013-14 |
| Investigator(s): | Zhou Z |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Outstanding Researcher Award |
| Start Date: | 12/2014 |
| Project Title: | Lamin A in Chromatin Dynamics and Aging |
| Investigator(s): | Zhou Z |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Croucher Senior Research Fellowships in Natural Sciences, Technology and Medicine |
| Start Date: | 01/2016 |
| Project Title: | SIRT6 in bone marrow stromal cell potency and the development of osteoporosis |
| Investigator(s): | Zhou Z |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2016 |
| Project Title: | SIRT6 deacetylates p53 to modulate cellular senescence and aging |
| Investigator(s): | Zhou Z |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 07/2016 |