School of Biomedical Sciences

SCHOOL OF BIOMEDICAL SCIENCES

Researcher : AN L

List of Research Outputs

AN L., Jiang Y.Y., Ng H.W.H., Chen J., Gong Q.G. and Huen M.S.Y., A Dual Utility NLS Drives RNF169-dependent DNA Damage Responses, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

AN L., JIANG Y., Ng H.W.H., Man P.S., CHEN J., Khoo U.S., Gong Q. and Huen M.S.Y., Dual-utility NLS Drives RNF169-dependent DNA Damage Responses, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

An L., Jiang Y., Ng H.L.L., Man P.S., Chen J., Khoo U.S., Gong Q. and Huen M.S.Y., Dual-utility NLS drives RNF169-dependent DNA damage responses, Proc Natl Acad Sci U S A. 2017, 114(14): E2872-E2881.

GUO Y., AN L., NG H.M., Sy M.H. and Huen M.S.Y., An E2-guided E3 Screen Identifies the RNF17-UBE2U Pair as Regulator of the Radiosensitivity, Immunodeficiency, Dysmorphic Features, and Learning Difficulties (RIDDLE) Syndrome Protein RNF168., Journal Of Biological Chemistry. 2017, 292: 967-978.

Researcher : ARYA S

List of Research Outputs

XU C., LIN Q., DENG J., Yu B., ARYA S. and Huang J., Live attenuated Salmonella-based Vaccines delivering SaEsxA by Type III Secretion System Confer Protection against Staphylococcus aureus Infection, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : An L

List of Research Outputs

Researcher : Au YK

List of Research Outputs

QIN Y., Ng R.K., Ng T.W., Tong K.K., Au Y.K., Niu B., Tan Z., Yip M.S., Wang J.J., Sham P.C. and Cheah K.S.E., Genome-wide identification of active enhancers in the developing mouse nucleus pulposus, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

ZHANG C., LIM F.L., Tam W.K., Au Y.K., Cheah K.S.E., Cheung K.M.C. and Leung V.Y.L., Development of Intervertebral disc degeneration in N-cadherin mutant mouse, Gordon Research Conference: Cartilage Biology & Pathology, Lucca. 2017.

ZHANG C., LIM F.L., Tam W.K., Au Y.K., Cheah K.S.E., Cheung K.M.C. and Leung V.Y.L., Development of lumbar disc degeneration in cadherin 2 mouse mutant, The Annual Meeting of the International Society for the Study of the Lumbar Spine, Athens. 2017.

Researcher : BHUYAN SK

List of Research Outputs

BHUYAN S.K., Kinghorn A.B., TANG Y.H., Shum H.C. and Tanner J.A., A high throughput approach for discovery of catalytic nucleic acids, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : Ballard HJ

Project Title:	Involvement of Pannexin 1 in CFTR-regulated ATP release from skeletal muscle
Investigator(s):	Ballard HJ
Department:	School of Biomedical Sciences
Source(s) of Funding:	Small Project Funding
Start Date:	05/2015
Completion Date:	04/2017

Project Title:	Transmembrane-channel interactions in pre- and post-ischaemic cardioprotection
Investigator(s):	Ballard HJ
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

Project Title:	The role of cystic fibrosis transmembrane conductance regulator in the heart
Investigator(s):	Ballard HJ
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

List of Research Outputs

LI C., LU Y.Y., YUE J. and Ballard H.J., Saikosaponin D, a novel autophagy inhibitor, potently inhibited Enterovirus 71(EV71)- induced cell death, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

WU T.H.E. and Ballard H.J., CFTR-associated ATP Release in Neonatal And Adult Skeletal Myoblasts, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

WU T.H.E., LU L., WANG Y. and Ballard H.J., Connexin 43, Pannexin 1 and Cystic Fibrosis Transmembrane Conductance Regulator in the Regulation of ATP Release From Muscle, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

Researcher : Bao S

Project Title:	Prioritizing genes from runs of homozygosity associated with Alzheimer's disease by combined analysis of rare variants and gene networks
Investigator(s):	Bao S, Song Y, Zhou X
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	04/2015
Completion Date:	09/2016

List of Research Outputs

YU Z., TANG L.F., WANG J., Bao S., SHIEH J.T., LEUNG A.W.L., Gao F., ZHANG Z., WONG S.Y.Y., HUI A.L.C., Dung W.F., ZHANG Z., Fan Y., Wong S.M., Sham P.C., AZHAR A., KWOK P.Y., TAM P.P.L., Lian Q. and Cheah K.S.E., Hnrnpa1 Mutations Cause Congenital Heart Defects, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : CAO F

List of Research Outputs

CAO F., Tsao G.S.W. and Yu C., Regulation of Integrin beta3 Endocytosis at the Podosome, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

ZHOU Y., Zhang Y.G., CAO F., SIT H.M., Tsao G.S.W. and Yu C., Define the Functional Role of Myosin-1e at the Macrophage Podosome, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

Researcher : CHAI S

List of Research Outputs

CHAI S., Ng K.Y., Tong M., Lau Y.T., Lee K.W., Chan K.W., Yuan Y.F., Cheung T.T., Cheung S.T., Wang X., Wong N., Lo C.M., Man K., Guan X. and Ma S.K.Y., Oct4/miR-1246 signaling axis drives Wnt/β-catenin activation in liver cancer stem cells, Hepatology. 2016.

Fung T.M., Ng K.Y., Tong M., CHEN J., Chai S., Chan K.T., Law S.Y.K., Lee N.P.Y., Choi M.Y., Li B., Cheung A., Tsao G.S.W., Qin Y.R., Guan X., Chan K.W. and Ma S.K.Y., Neuropilin-2 promotes tumourigenicity and metastasis in oesophageal squamous cell carcinoma through ERK-MAPK-ETV4-MMP-E-cadherin deregulation, Journal of Pathology. 2016, 239(3): 309-319.

Ng K.Y., CHAI S., Tong M., Guan X., Lin C., Ching Y.P., Xie D., Cheng A.S. and Ma S.K.Y., C-terminal truncated hepatitis B virus X protein promotes hepatocellular carcinogenesis through induction of cancer and stem cell-like properties, Oncotarget. 2016.

Researcher : CHAN CK

List of Research Outputs

CHAN C.K. and OENTARYO M.J., Xenopus nerve-muscle cultures: a novel cell-based assay for serological diagnosis and pathological research of myasthenia gravis, Current Pathobiology Reports. 2017, 5(1): 57-65.

Researcher : CHAN HL

List of Research Outputs

CHAN H.L., Huang J. and Lai K.O., The Kinesin Motor Protein KIF5B Regulates RNA Trafficking and Dendritic Spine Morphogenesis in Hippocampal Neuron, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

CHAN H.L., Huang J. and Lai K.O., To elucidate the role of the Kinesin motor protein KIF5B in mRNA transport and dendritic spine morphogenesis, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : CHAN LH

List of Research Outputs

CHAN L.H., Functional and Mechanistic Characterization of PRMT6 in Regulating the Diverse Cellular Properties Implicated in the Pathogenesis of Hepatocellular Carcinoma (PhD Thesis), The University of Hong Kong. 2016.

CHAN L.H. and Ma S.K.Y., PRMT6-Dependent CRAF/ERK Signaling Regulates Cancer Stem Cell Plasticity in Liver Cancer, 4th International Anatomical Sciences & Cell Biology Conference. 2016.

Researcher : CHAN MHM

List of Research Outputs

CHAN M.H.M., Lau K.L.K., Lin W., Tsao G.S.W. and Tsang C.M., The interaction of berberine with chemodrugs on Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : CHAN PC

List of Research Outputs

CHAN P.C., Identifiying and characterizing a planarian ortholog of FOXO transcription factors in the regulation of stem cell function and tissue regeneration (MPhil Thesis), The University of Hong Kong. 2016.

Researcher : CHAN SHV

List of Research Outputs

CHAN S.H.V. and Ching Y.P., The role of Nek2 in hepatocellular carcinoma, 2017 AACR Annual meeting. D.C. Washington, USA, 2017.

CHAN S.H.V. and Ching Y.P., The role of Nek2 in hepatocellular carcinoma, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : CHAUDHARY V

List of Research Outputs

CHAUDHARY V. and Jin D., American Society for Virology Student Travel Award 2017, American Society for Virology. 2017.

CHAUDHARY V., Zhang S., Yuen K.S., Li D., Kok K.H., Liang M. and Jin D., Differential modulation of type I and type II interferon signaling by severe fever-with-thrombocytopenia syndrome virus NSs protein., 2016 World Life Science Conference. Beijing, China, 2016.

CHAUDHARY V., ZHANG S., LI D., LIANG M., Kok K.H. and Jin D., Dual regulatory effects of SFTS virus NSs protein on interferon signaling, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

CHAUDHARY V., Reaching Out Award 2017, HKSAR Government Scholarship Fund. 2017.

CHAUDHARY V., Yuen K.S., Chan J.F.W., Chan C.P., Kok K.H., Chan C.P., Yuen K.Y. and Jin D., Selective activation of interferon-γ signaling by Zika virus NS5 protein (invited speaker)., 2016 World Life Science Conference.. Beijing, China, 2016.

CHAUDHARY V., Zhang S., Yuen K.S., Li D., Liang M.F. and Jin D., Severe fever-with-thrombocytopenia syndrome virus NSs protein exerts opposite regulatory roles on type I and type II interferon signaling., The American Society for Virology 36th Annual Meeting, University of Wisconsin-Madison, Madison, Wisconsin, USA, June 23-28, 2017.. 2017.

CHAUDHARY V., Tigris Educational Fund - Graduate Student Travel Scholarship 2017, Tigris Educational Fund. 2017.

CHAUDHARY V., Yuen K.S., Chan J.F.W., Chan C.P., Wang F., Kok K.H., Chan C.P., Yuen K.Y. and Jin D., Zika virus NS5 protein differentially modulates type I and type II interferon signaling., Cross Street Immunology Conference, National Taiwan University, Taipei, March 18-19, 2017.. 2017.

Chaudhary V., Yuen K.S., Chan J.F.W., Chan C.P., Wang F., Cai J., Zhang S., Liang M., Kok K.H., Chan C.P., Yuen K.Y. and Jin D., Selective activation of type II interferon signaling by Zika virus NS5 protein, J Virol. 2017, 91(14): e00163-17.

Deng J., Kong K.Y., Gao W., Tang H.M.V., CHAUDHARY V., CHENG Y., Zhou J., Chan C.P., Wong D.K.H., Yuen R.M.F. and Jin D., Interplay between SIRT1 and hepatitis B virus X protein in the activation of viral transcription, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 2017, 1860: 491-501.

Jin D., CHAUDHARY V., Yuen K.S., Chan J.F.W., Chan C.P. and Yuen K.Y., Zika virus NS5 protein suppresses type I and type III interferon signaling but augments type II interferon signaling., The American Society for Virology 36th Annual Meeting, University of Wisconsin-Madison, Madison, Wisconsin, USA, June 23-28, 2017.. 2017.

Kong K.Y., Deng J., GAO W., Tang H.M.V., CHAUDHARY V., CHENG Y., Wong D.K.H., Yuen R.M.F., Ma S.K.Y., Chan C.P. and Jin D., PRMT5 protein arginine methyltransferase activates hepatitis B virus transcription., 2016 International HBV Meeting.. Seoul, Korea, 2016.

Rezelj V.V., Li P., CHAUDHARY V., Elliott R.M., Jin D. and Brennan B., Differential Antagonism of Human Innate Immune Responses by Tick-Borne Phlebovirus Nonstructural Proteins , mSphere. 2017, 2: e00234-17.

Researcher : CHE N

List of Research Outputs

Wong T.L., CHE N. and Ma S.K.Y., Reprogramming of Central Carbon Metabolism in Cancer Stem Cells, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2017, 1863: 1728-1738.

Researcher : CHEN J

List of Research Outputs

AN L., Jiang Y.Y., Ng H.W.H., Chen J., Gong Q.G. and Huen M.S.Y., A Dual Utility NLS Drives RNF169-dependent DNA Damage Responses, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

AN L., JIANG Y., Ng H.W.H., Man P.S., CHEN J., Khoo U.S., Gong Q. and Huen M.S.Y., Dual-utility NLS Drives RNF169-dependent DNA Damage Responses, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

An L., Jiang Y., Ng H.L.L., Man P.S., Chen J., Khoo U.S., Gong Q. and Huen M.S.Y., Dual-utility NLS drives RNF169-dependent DNA damage responses, Proc Natl Acad Sci U S A. 2017, 114(14): E2872-E2881.

XU W., Li N.F. and Chen J., Effects of the Apical Krebs Solution on Ion Transport of Cultured Pig Tracheal Epithelia, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

XU W., Li N.F. and Chen J., Sodium in The Apical Solution Mediates Downregulation of Ion Transport in Cultured Pig Tracheal Epithelia, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

ZHU S. and Chen J., Bacterial Killing of Cultured Pig Tracheal Epithelia was not Altered by HCO3--Free Medium, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

Researcher : CHEN L

List of Research Outputs

Xie Y., Ge J., Lei H., Peng B., Zhang H., Wang D., Pan S., Chen G., CHEN L., Wang Y., Hao Q., Yao S.Q. and Sun H.Y., Fluorescent Probes for Single-Step Detection and Proteomic Profiling of Histone Deacetylases, Journal of the American Chemical Society. 2016, 138: 15596-15604.

Researcher : CHEN X

List of Research Outputs

CHEN X., Regional Disturbances by The DF508 Mutation on The Cystic Fibrosis Transmembrance Conductance Regulator (PhD Thesis), The University of Hong Kong. 2016.

Researcher : CHENG SY

List of Research Outputs

SHAH A.N., Hung H.L.C., Cheng S.Y., WONG M.Y., Legido-Quigley C. and Chang R.C.C., Oxyresveratrol mitigates cellular toxicity in and in-vitro and in-vivo model of Parkinson’s disease, The 13th International Conference on Alzheimer’s & Parkinson’s Diseases 2017, Section C02.g Therapeutic targets, mechanisms for treatment: anti- inflammatory, anti-oxidant.. 2017, 146.

WONG M.Y., SHAH A.N., CHENG S.Y. and Chang R.C.C., Effects on Oxyresveratrol on Motor and Cognitive Functions in 6-OHDA-Induced Parkinson’s Disease, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

Researcher : CHENG TF

List of Research Outputs

. S., Yuen K.S., WONG N.H.M., CHENG T.F., Botelho M.G. and Jin D., CRISPR/Cas9 targeting of viral essential genes suppresses Epstein- Barr virus DNA load in nasopharyngeal carcinoma cells of latency II., The American Society for Virology 36th Annual Meeting, University of Wisconsin-Madison, Madison, Wisconsin, USA, June 23-28, 2017.. 2017.

CHENG T.F. and Jin D., Caspase 3 activation and apoptosis facilitates lytic induction of Epstein- Barr virus in epithelial cells, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Yuen K.S., Wang Z.M., WONG N.H.M., Zhang Z.Q., CHENG T.F., LUI W.Y., Chan C.P. and Jin D., Suppression of Epstein-Barr virus DNA load in latently infected nasopharyngeal carcinoma cells by CRISPR/Cas9, Virus Res.. 2017.

Researcher : CHENG Y

List of Research Outputs

CHENG Y., b-TrCP-mediated ubiquitination and degradation of liver-enriched transcription factor CREB-H (PhD Thesis), The University of Hong Kong. 2016.

CHENG Y., GAO W., Tang H.M.V. and Jin D., β-TrCP targets liver-enriched and membrane-bound transcription factor CREB-H for ubiquitination and degradation., 16th International Union of Biochemistry and Molecular Biology (IUBMB) Conference: Signaling Pathways in Development, Diseases and Aging.. Vancouver, Canada, 2016.

Deng J., Kong K.Y., Gao W., Tang H.M.V., CHAUDHARY V., CHENG Y., Zhou J., Chan C.P., Wong D.K.H., Yuen R.M.F. and Jin D., Interplay between SIRT1 and hepatitis B virus X protein in the activation of viral transcription, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 2017, 1860: 491-501.

GAO W., Tang H.M.V., CHENG Y., WANG P. and Jin D., Regulation of ubiquitination and degradation of CRTC1 transcriptional coactivator by salt-inducible kinase SIK1., 16th International Union of Biochemistry and Molecular Biology (IUBMB) Conference: Signaling Pathways in Development, Diseases and Aging.. Vancouver, Canada, 2016.

Kong K.Y., Deng J., GAO W., Tang H.M.V., CHAUDHARY V., CHENG Y., Wong D.K.H., Yuen R.M.F., Ma S.K.Y., Chan C.P. and Jin D., PRMT5 protein arginine methyltransferase activates hepatitis B virus transcription., 2016 International HBV Meeting.. Seoul, Korea, 2016.

Researcher : CHEUNG PHH

List of Research Outputs

Chan C.P., Yuen C.K.J., Fung S.Y., CHEUNG P.H.H., Chen H., Kok K.H. and Jin D., Antiviral activity of double-stranded RNA-binding protein PACT against influenza A virus mediated through suppression of viral RNA polymerase, FOCIS 2017.

Researcher : CHOW WH

List of Research Outputs

CHOW W.H., Cham W.C., Chan Y.S. and Shum D.K.Y., Neuronal and astrocytic proheparanase: Insights on its role in regulating synaptic transmission in central nervous system, Abstracts of 12^th Int’l Symp. on Healthy Aging: Science and Aging – Wellness and Longevity: From Science to Service : 78. [HK. March 11-12, 2017]. 2017.

CHOW W.H., Cham W.C., Chan Y.S. and Shum D.K.Y., Neuronal and astrocytic proheparanase: Roles in regulating synaptic strength in rat hippocampus, Abstracts of 10^th FENS Forum of Neuroscience, 761. [Copenhagen, Denmark. July 2-6, 2016]. 2016.

Researcher : CHU TL

List of Research Outputs

CHU T.L., Tsang K.Y., Tsang S.W., Zhou Z. and Cheah K.S.E., MMP14 Regulates Lineage Progression of Hypertrophic Chondrocytes, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

CHU T.L., Tsang K.Y., Zhou Z. and Cheah K.S.E., MMP14 and Regulation of the Hypertrophic Chondrocyte to Osteoblast Lineage, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : CHUNG WH

List of Research Outputs

Cheng W.H., Chung W.H. and NG J.C.F., Structural Dynamics of Amyloid-β Aggregation in Alzheimer’s Disease: Computational and Experimental Approaches, Journal of Young Investigators. 2016.

Wang Y., Fung E.Y.M., ZHANG W., He B., CHUNG W.H., Jin J., Hu J., Lin H.N. and Hao Q., Deacylation Mechanism by SIRT2 Revealed in the 1′-SH-2′-O-Myristoyl Intermediate Structure, Cell Chemical Biology. 2017, 24: 339-345.

Researcher : Cai S

List of Research Outputs

Cai S., Han L., Ao Q., Chan Y.S. and Shum D.K.Y., Human induced pluripotent stem cell-derived sensory neurons for fate commitment of bone marrow-derived Schwann cells: Implications for re-myelination therapy, Stem Cells Translational Medicine. 2017, 6: 369-381.

Shum D.K.Y., Tsui Y.P., Cai S. and Chan Y.S., iPSC-derived sensory neurons for fate commitment of bone marrow-derived Schwann cells: Implication for re-myelination therapy, Frontiers in Cellular Neuroscience [14^th Meeting of Asian Pacific Society for Neurochemistry. Kuala Lumpur. August 27-30, 2016]. 2016.

Researcher : Chai S

List of Research Outputs

Researcher : Chan CP

List of Research Outputs

CHAUDHARY V., Yuen K.S., Chan J.F.W., Chan C.P., Kok K.H., Chan C.P., Yuen K.Y. and Jin D., Selective activation of interferon-γ signaling by Zika virus NS5 protein (invited speaker)., 2016 World Life Science Conference.. Beijing, China, 2016.

CHAUDHARY V., Yuen K.S., Chan J.F.W., Chan C.P., Wang F., Kok K.H., Chan C.P., Yuen K.Y. and Jin D., Zika virus NS5 protein differentially modulates type I and type II interferon signaling., Cross Street Immunology Conference, National Taiwan University, Taipei, March 18-19, 2017.. 2017.

Chan C.P., Yuen C.K.J., Fung S.Y., CHEUNG P.H.H., Chen H., Kok K.H. and Jin D., Antiviral activity of double-stranded RNA-binding protein PACT against influenza A virus mediated through suppression of viral RNA polymerase, FOCIS 2017.

Chaudhary V., Yuen K.S., Chan J.F.W., Chan C.P., Wang F., Cai J., Zhang S., Liang M., Kok K.H., Chan C.P., Yuen K.Y. and Jin D., Selective activation of type II interferon signaling by Zika virus NS5 protein, J Virol. 2017, 91(14): e00163-17.

Deng J., Kong K.Y., Gao W., Tang H.M.V., CHAUDHARY V., CHENG Y., Zhou J., Chan C.P., Wong D.K.H., Yuen R.M.F. and Jin D., Interplay between SIRT1 and hepatitis B virus X protein in the activation of viral transcription, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 2017, 1860: 491-501.

Deng J., Kong K.Y., GAO W., Tang H.M.V., Chan C.P. and Jin D., Sirtuins are potent activators of hepatitis B virus transcription., 2016 International HBV Meeting.. Seoul, Korea, 2016.

FUNG S.Y., YUEN C.K., ZHU W., LIANG G., Kok K.H., Chan C.P. and Jin D., Activation of nucleic acid sensing cGAS-STING pathway by Sindbis Virus, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

FUNG S.Y., Chan C.P., YUEN C.K., Kok K.H., Chan C.P. and Jin D., Human T-cell leukemia virus type 1 Tax and HBZ proteins differentially suppress RNA- and DNA-induced innate antiviral response., 18th International Conference on Human Retrovirology: HTLV-1 and Related Viruses, Tokyo, Japan, March 7-10, 2017.. 2017.

Jin D., GAO W., Deng J., Kong K.Y. and Chan C.P., Suppression of hepatitis B virus transcription by LKB1 tumor suppressor and salt-inducible kinases, 2016 International HBV Meeting. Seoul, Korea, 2016.

Jin D., CHAUDHARY V., Yuen K.S., Chan J.F.W., Chan C.P. and Yuen K.Y., Zika virus NS5 protein suppresses type I and type III interferon signaling but augments type II interferon signaling., The American Society for Virology 36th Annual Meeting, University of Wisconsin-Madison, Madison, Wisconsin, USA, June 23-28, 2017.. 2017.

Kong K.Y., Deng J., GAO W., Tang H.M.V., CHAUDHARY V., CHENG Y., Wong D.K.H., Yuen R.M.F., Ma S.K.Y., Chan C.P. and Jin D., PRMT5 protein arginine methyltransferase activates hepatitis B virus transcription., 2016 International HBV Meeting.. Seoul, Korea, 2016.

WONG N.H.M., Yuen K.S., Chan C.P. and Jin D., Suppression of IFN-β production by Epstein-Barr virus lytic transactivator Zta., Immunology 2017 – The American Association of Immunologists Meeting, Walter E. Washington Convention Center, Washington, D.C., USA, May 12-16, 2017.. 2017.

Wang F., FUNG S.Y., Chan C.P. and Jin D., Induction by HTLV-1 of a transcript isoform of STING that suppresses innate antiviral response., 18th International Conference on Human Retrovirology: HTLV-1 and Related Viruses, Tokyo, Japan, March 7-10, 2017.. 2017.

Yuen K.S., Chan C.P., Kok K.H. and Jin D., Mutagenesis and genome engineering of Epstein-Barr virus in cultured human cells by CRISPR/Cas9., Methods in Molecular Biology. 2016, 1498: 23-31.

Yuen K.S., Wang Z.M., WONG N.H.M., Zhang Z.Q., CHENG T.F., LUI W.Y., Chan C.P. and Jin D., Suppression of Epstein-Barr virus DNA load in latently infected nasopharyngeal carcinoma cells by CRISPR/Cas9, Virus Res.. 2017.

Researcher : Chan CP

Project Title:	Regulation of hepatitis B virus transcription by PRMT5 protein arginine methyltransferase
Investigator(s):	Chan CP, Zhou J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	08/2015

Project Title:	Characterization of a novel b-TrCP ubiquitin ligase-dependent mechanism for ubiquitination and degradation of liver-enriched transcription factor CREB-H
Investigator(s):	Chan CP, Yuen KS, Lui PY
Department:	School of Biomedical Sciences
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - Science Fund for Young Scholars
Start Date:	01/2016

Project Title:	Antiviral activity of cGAS/cGAMP against RNA virus infection
Investigator(s):	Chan CP
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2016

Project Title:	FOCIS 2017; Antiviral activity of double-stranded RNA-binding protein PACT against influenza A virus mediated through suppression of viral RNA polymerase
Investigator(s):	Chan CP
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2017
Completion Date:	06/2017

Project Title:	Roles of Middle East respiratory syndrome coronavirus ORF8b protein in Type I interferon antagonism
Investigator(s):	Chan CP
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

List of Research Outputs

Deng J., Kong K.Y., GAO W., Tang H.M.V., Chan C.P. and Jin D., Sirtuins are potent activators of hepatitis B virus transcription., 2016 International HBV Meeting.. Seoul, Korea, 2016.

Yuen K.S., Chan C.P., Kok K.H. and Jin D., Mutagenesis and genome engineering of Epstein-Barr virus in cultured human cells by CRISPR/Cas9., Methods in Molecular Biology. 2016, 1498: 23-31.

Researcher : Chan CWY

Project Title:	Human embryonic stem cell-derived cardiomyocyte as a model to study the role of autophagy in cardiac inflammation
Investigator(s):	Chan CWY, Li RA
Department:	Anatomy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	11/2013
Completion Date:	11/2016

List of Research Outputs

Tse G., Liu T., Li K.H., Laxton V., WONG O.T., Chan Y.W., Keung W.W.Y., Chan C.W.Y. and Li R.A., Tachycardia-bradycardia syndrome: Electrophysiological mechanisms and future therapeutic approaches (Review), International Journal of Molecular Medicine. 2017.

Researcher : Chan D

Project Title:	Genome-wide identification and functional studies of genetic risk factors for low back pain and intervertebral disc degeneration
Investigator(s):	Chan D
Department:	School of Biomedical Sciences
Source(s) of Funding:	AOSpine International - General Award
Start Date:	08/2007

Project Title:	Research Output Prize (Li Ka Shing Faculty of Medicine)
Investigator(s):	Chan D
Department:	Biochemistry
Source(s) of Funding:	Research Output Prize (in Faculty)
Start Date:	12/2010

Project Title:	Interplay between ER stress and hypoxic stress in the regulation of chondrocyte differentiation
Investigator(s):	Chan D, Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2012

Project Title:	Integrative Approaches to Understanding Disorders of the Skeleton
Investigator(s):	Chan D
Department:	School of Biomedical Sciences
Source(s) of Funding:	Croucher Advanced Study Institute
Start Date:	12/2013

Project Title:	Progenitor cells in the formation and repair of articular cartilage
Investigator(s):	Chan D, Cheah KSE, Chan BP
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014

Project Title:	Mechanisms of energy management in hypertrophic chondrocyte adaptation to ER Stress
Investigator(s):	Chan D, Chan BP, Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	Cellular changes in spinal curvature from FGFR3 mutations and response to drug treatment
Investigator(s):	Chan D, To MKT
Department:	School of Biomedical Sciences
Source(s) of Funding:	France/Hong Kong Joint Research Scheme - Travel Grants
Start Date:	01/2016

Project Title:	IHH regulating CDO/GAS1 function in synovial joint formation
Investigator(s):	Chan D, Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2017

List of Research Outputs

KWON Y.J., Chan W.C.W. and Chan D., Postnatal Expression of Pax1 in the Intervertebral Disc during Postnatal Growth and Response to Spinal Curvature, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

LAM Y., Chan W.C.W., Feng C., Chan B.P. and Chan D., Understanding the contribution of Lgr5+ interzone progenitor cells in articular cartilage development and regeneration, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

SO K.H., Kudelko M.A., Tan Z., Wang C., Chan W.C.W., Tsang K.Y., Cheah K.S.E. and Chan D., FGF21 Up-Regulates Glycolytic Proteins for Hypertrophic Chondrocyte Survival under ER Stress, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Tsang K.Y., Li X.Y., Wu M.H., Jin G., Chan D., Zhang M.Q. and Cheah K.S.E., Single cell transcriptomes reveal a mesenchymal state during chondrocyte to osteoblast transition., Keystone Symposium Single Cell Omics, May 26-30, 2017, Stockholm. 2017.

Wang Y., Wu M.H., Cheung M.P.L., Sham M.H., Haruhiko A., Chan D., Cheah K.S.E. and Cheung M.C.H., Reprogramming of Dermal Fibroblasts into Osteo-Chondrogenic Cells with Elevated Osteogenic Potency by Defined Transcription Factors, Stem Cell Reports. 2017, 8: 1587-1599.

Researcher : Chan LK

Project Title:	Perception by LKS Faculty of Medicine graduates on their university education
Investigator(s):	Chan LK, Ip MSM, Patil NG, Prosser MT
Department:	Bau Institute of Medical and Health Scie
Source(s) of Funding:	Teaching Development Grants
Start Date:	06/2008

Project Title:	Identifying the English language and communicative demands of bedside learning on students in the clinical years
Investigator(s):	Chan LK, Tse LK, Storey AM
Department:	Bau Institute of Medical and Health Scie
Source(s) of Funding:	Medical Faculty Research Grant Fund
Start Date:	06/2008

Project Title:	Assessing competency of dental graduates from problem-based learning and traditional curriculums: Graduates’ and Employers’ Perceptions
Investigator(s):	Chan LK, Yiu CKY, Botelho MG, Bridges SM, Corbet EF, Dyson JE, McGrath CPJ, Wong RWK, Prosser MT
Department:	Bau Institute of Medical and Health Scie
Source(s) of Funding:	Teaching Development Grants
Start Date:	12/2008

Project Title:	Designing technology-rich environments for case-based instruction: a model for life-long learning
Investigator(s):	Chan LK, Lu J
Department:	Bau Institute of Medical and Health Scie
Source(s) of Funding:	International Opportunities Fund
Start Date:	03/2010

Project Title:	Development of a fit-for-purpose Chinese-language course for the medical students
Investigator(s):	Chan LK, Soo YC, Tse SK
Department:	Bau Institute of Medical and Health Scie
Source(s) of Funding:	Faculty Development Fund of Faculty of Medicine
Start Date:	06/2011

Project Title:	The use of mobile devices in problem-based learning
Investigator(s):	Chan LK, Bridges SM, Doherty I, Jin J, Ng ML
Department:	Bau Institute of Medical and Health Scie
Source(s) of Funding:	Teaching Development Grants
Start Date:	07/2013

List of Research Outputs

Bridges S.M., Botelho M.G., Chan L.K., Chan C.K.K., Wong A.M.Y., Green J. and Hmelos-Silver C., Bronze Award (Asia Region): Problem-based Learning and Educational Technologies in Clinical Education: An Interactional Ethnography, QS Wharton Reimagine Education Awards . 2016.

Bridges S.M. and Chan L.K., Technology-enhanced medical education: An Interactional Ethnography, American Educational Research Association (AERA) Annual Meeting. 2017.

Chan L.K., Assessment in Interprofessional Learning., Chinese University Medical Education Conference, organised by Chinese University of Hong Kong. 2017.

Chan L.K., Wong F.K.Y., Ganotice F.J.A., Lau W.C.S., Lam T.P., Bridges S.M., Chan N.K., Chan W.L.P., Chen H., Chen J.Y., Chu K.P.J., Ho C.C., Ho J.M.C., Chin W.Y., Harbutt D., Khoo U.S., Lam S.F., Lao L., Leung G.K.K. and Li Q., Bronze in Discipline Award (Life Sciences), in Quacquarelli Symonds (QS) Reimagine Education competition: Interprofessional Team-Based Learning for Health Professional Students, Quacquarelli Symonds. 2016.

Chan L.K., Changing from passive to active learning: making dissection clinically relevant, International Anatomical Sciences and Cell Biology Conference 2016 (IASCBC).. 2016.

Chan L.K., Editor, MOOC in postmodern Asia. 2016.

Chan L.K., Editorial Board Member, Journal of Educational Evaluation of Health Profession (JEEHP). Korea Health Personnel Licensing Institute, 2016.

Chan L.K., Evolution of shoulder anatomy, Multidisciplinary Musculoskeletal Ultrasound Congress on Pain Management, Hong Kong.. 2017.

Chan L.K., Experience Sharing on the Planning, Development and Implementation of an Interprofessional Team-Based Learning Programme across Two Universities, Seminar organized by the Faculty of Health and Social Sciences, The Hong Kong Polytechnic University, Hong Kong.. 2017.

Chan L.K., Faculty Education Programme (FEP) for orthopedic surgeons, Hong Kong, June 2017, Invited educator and faculty in the Faculty Education Programme, organized by AOTrauma, 2017.

Chan L.K., Faculty Education Programme (FEP) for orthopedic surgeons, Hong Kong, March 2017, Invited educator and faculty in the Faculty Education Programme, organized by AOTrauma, 2017.

Chan L.K., Faculty Education Programme (FEP) for orthopedic surgeons, Hong Kong, Sept 2016, Invited educator and faculty in the Faculty Education Programme, organized by AOTrauma, 2016.

Chan L.K., Faculty Education Programme (FEP) for orthopedic surgeons, Wuhan, China, Nov 2016, Invited educator and faculty in the Faculty Education Programme, organized by AOTrauma, 2016.

Chan L.K., Chen J.Y. and Chung W.S.E., Hong Kong Publishing Biennial Awards 2017, "Publishing Award” in the category of "Life and Science”, for the book “Dissecting the Meaning of Life – An Anthology of Essays on Body Donation” (大體大得——遺體捐贈感思文集), Hong Kong Publishing Professionals’s Society. 2017.

Chan L.K., Life and Death Education in Body Donation, Symposium on organ and body donation organised by Chi Sun College, Hong Kong.. 2017.

Chan L.K., Promoting active learning, The Summer Institute: Higher Education for Tomorrow. Organized by the Faculty of Education, HKU.. 2017.

Chan L.K., Promoting reflection in dissection, Invited plenary speaker in the Annual Meeting of the Chinese Society for Anatomical Sciences ( 中国解剖学会学术年会). 2016.

Chan L.K. and Ganotice F.J.A., Readiness for interprofessional learning: A cross-discipline comparison involving healthcare students in Hong Kong, The 14th Asia Pacific Medical Education Conference. 2017.

Chan L.K., Symposium on e-learning, team-based learning, and Second Life, Medical Education Conference 2017 (Modern Trends in Medical Education), organised by the Hong Kong Academy of Medicine. 2017.

Chan L.K., Team-based learning for interprofessional education, Staff Development Series (Teaching) in School of Nursing, HKU.. 2017.

Chan L.K., The use of Learning Activity Management System (LAMS) in Interprofessional Team-Based Learning (IPTBL) for health professional students, Seminar organized by Centre for Information Technology in Education, HKU.. 2016.

Chin W.Y., Chen J.Y., Chan L.K., Wan Y.F. and Chan K.C., Health-related quality of life and mental health of HKU MBBS graduates: a cross-sectional study of MBBS graduates from 1995-2014, 2016 Frontiers in Medical and Health Sciences Education Conference, Hong Kong. 2016.

Cunanan C.C., Kambey D.R., Chan L.K. and Snyman S., Starting IPECP (New interprofessional education and collaborative practice) networks from scratch: Sharing and learning from each other in overcoming challenges, All Together Better Health VIII International Conference. 2016.

Ganotice F.J.A. and Chan L.K., A second look into the factor structures of Readiness for Interprofessional Learning Scale (RIPLS) involving Chinese students in Hong Kong, The 14th Asia Pacific Medical Education Conference. 2017.

Ganotice F.J.A. and Chan L.K., Construct Validation of Readiness for Interprofessional Learning Scale (RIPLS) for Chinese undergraduate students, All Together Better Health VIII International Conference. 2016.

Ganotice F.J.A. and Chan L.K., Psychometric validity and gender invariance of Readiness for Interprofessional Learning Scale (RIPLS) involving students in Hong Kong, Frontiers in Medical and Health Sciences Education. 2016.

Ganotice F.J.A. and Chan L.K., Students’ achievement in interprofessional team-based learning: A cross-discipline comparison involving biomedical sciences, Chinese medicine, medicine, nursing, pharmacy, and social work students in Hong Kong, Frontiers in Medical and Health Sciences Education. 2016.

Ho J.W.Y., Ngan W.L., Chan L.K., Cook S. and Bridges S.M., Assessments for Learning - A Double Edged-Sword? , Frontiers in Medical and Health Sciences Education. 2016.

Hogaboam P.T., Chen Y., Hmelo-Silver C.E., Lajoie S.P., Bodnar S., Kazemitabar M., Wiseman J. and Chan L.K., Data Dashboards to Support Facilitating Online Problem-based Learning, The Quarterly Review of Distance Education. 2016, 17(3): 75-91.

Hui R.W.H., Leung S.S.N., Cheung T.L.C., Chu E.W.M., Fong J.C.Y., Lau I.H.W., Leung V.C.Y., Leung E., Yip K.K.Y., Yung V., Chen K. and Chan L.K., Preclinical medical students′ usage of electronic devices in lectures: A cross-sectional study, Digital Medicine. 2016, 2(2): 64-9.

Kazemitabar M.A., Bodnar S., Hogaboam P., Chen Y., Sarmiento Y.P., Lajoie S.P., Hmelo-Silver C., Goldman R., Wiseman J. and Chan L.K., Creating Instructor Dashboards to Foster Collaborative Learning in On-line Medical Problem Based Learning Situations, 18th International Conference on Human-Computer Interaction (HCII 2016). 2016.

Lee E.Y.P., Khong P.L., Kwong T.S.P., Chau M.T., Vardhanabhuti V. and Chan L.K., Integration of Ultrasound into the Undergraduate Medical Curriculum, Frontiers in Medical and Health Sciences Education. 2016.

YE L., Chan L.K., Bridges S.M. and Ganotice F.J.A., Technology Enhanced Interprofessional Education in Health Sciences Education: A Systematical Review, Frontiers in Medical and Health Sciences Education. 2016.

Researcher : Chan WCW

Project Title:	Understanding the Differentiation of Inner Annulus Fibrosus Cells: An in vitro Approach
Investigator(s):	Chan WCW, Chan D
Department:	School of Biomedical Sciences
Source(s) of Funding:	Small Project Funding
Start Date:	06/2015
Completion Date:	11/2016

List of Research Outputs

KWON Y.J., Chan W.C.W. and Chan D., Postnatal Expression of Pax1 in the Intervertebral Disc during Postnatal Growth and Response to Spinal Curvature, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

LAM Y., Chan W.C.W., Feng C., Chan B.P. and Chan D., Understanding the contribution of Lgr5+ interzone progenitor cells in articular cartilage development and regeneration, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

SO K.H., Kudelko M.A., Tan Z., Wang C., Chan W.C.W., Tsang K.Y., Cheah K.S.E. and Chan D., FGF21 Up-Regulates Glycolytic Proteins for Hypertrophic Chondrocyte Survival under ER Stress, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : Chan YS

Project Title:	30th Annual Conference of Society for Neuroscience Expression of N-Methyl-D-Aspartate Receptor Subunits and Induction of c-fos in Otolith Neurons in the Vestibular Nuclei of Postnatal Rats
Investigator(s):	Chan YS
Department:	Physiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2000

Project Title:	31st Annual Meeting of Society for Neuroscience Expression of Neurotrophin Receptors in Vestibular Nuclei During the Postnatal Development of the Rat
Investigator(s):	Chan YS
Department:	Physiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2001

Project Title:	XXIV Annual Conference of Indian Academy of Neurosciences Development Refinement of Spatial Recognition Circuits
Investigator(s):	Chan YS
Department:	Physiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	12/2006

Project Title:	Role of the thalamus in integrating spatial information and guiding navigation
Investigator(s):	Chan YS
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2009

Project Title:	Outstanding Research Student Supervisor Award 2009-10
Investigator(s):	Chan YS
Department:	Physiology
Source(s) of Funding:	Outstanding Research Student Supervisor Award
Start Date:	12/2010

Project Title:	Serotonin-induced bidirectional modulation of activity-dependent synaptic plasticity tunes vestibular functions
Investigator(s):	Chan YS, Shum DKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2013

Project Title:	Orexin-induced modulation of activity-dependent synaptic plasticity is critical for the maturation of vestibular circuitry and functions
Investigator(s):	Chan YS, Shum DKY, Lai CH
Department:	School of Biomedical Sciences
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2015

Project Title:	Semaphorin and perineuronal nets regulate developmental plasticity of central vestibular circuitry
Investigator(s):	Chan YS, Shum DKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2015

Project Title:	Neuronal Mechanism of Cholecystokinin-Facilitated Cross-modal Learning and Memory
Investigator(s):	Chan YS
Department:	School of Biomedical Sciences
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2016

Project Title:	Remodeling the sulfation pattern of perineuronal nets in the entorhinal cortical circuit prevents stress-induced decline in learning and memory
Investigator(s):	Chan YS, Lai SWC, Shum DKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

Project Title:	Integration of new neurons into the mature vestibular circuitry requires GABAergic signaling for relevant outcome in behavior
Investigator(s):	Chan YS, Lai SWC, Shum DKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2016

Project Title:	HKU Centennial Distinguished Chinese Scholars Scheme 2016-17
Investigator(s):	Chan YS
Department:	School of Biomedical Sciences
Source(s) of Funding:	HKU Centennial Distinguished Chinese Scholars Scheme
Start Date:	09/2016

Project Title:	Society for Neuroscience 46th Annual Meeting 2016; Prevation of Schwann cell identity in vitro through bone morphogenetic protein signaling
Investigator(s):	Chan YS
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2016
Completion Date:	11/2016

List of Research Outputs

CHOW W.H., Cham W.C., Chan Y.S. and Shum D.K.Y., Neuronal and astrocytic proheparanase: Insights on its role in regulating synaptic transmission in central nervous system, Abstracts of 12^th Int’l Symp. on Healthy Aging: Science and Aging – Wellness and Longevity: From Science to Service : 78. [HK. March 11-12, 2017]. 2017.

CHOW W.H., Cham W.C., Chan Y.S. and Shum D.K.Y., Neuronal and astrocytic proheparanase: Roles in regulating synaptic strength in rat hippocampus, Abstracts of 10^th FENS Forum of Neuroscience, 761. [Copenhagen, Denmark. July 2-6, 2016]. 2016.

Cai S., Han L., Ao Q., Chan Y.S. and Shum D.K.Y., Human induced pluripotent stem cell-derived sensory neurons for fate commitment of bone marrow-derived Schwann cells: Implications for re-myelination therapy, Stem Cells Translational Medicine. 2017, 6: 369-381.

Chan Y.S., Botelho F.P., Ma C.W., Shi W. and Shum D.K.Y., Developmental plasticity of brain circuits for navigational behavior. Frontiers in Cellular Neuroscience [14^th Meeting of Asian-Pacific Society for Neurochemistry, Kuala Lumpur August 27-30, 2016. 2016.

Chan Y.S., Tsui Y.P. and Shum D.K.Y., Preservation of Schwann cell identity in vitro through bone morphogenetic protein signaling, Soc. Neuroscience Abstract (USA), 390.05 [San Diego. Nov. 12-16, 2016]. 2016.

Chan Y.S., Ma C.W., Shi W. and Shum D.K.Y., Wiring of functional brain circuits for spatial orienting behavior, [International Conference of Physiological Sciences 2016 Beijing. September 25-28, 2016]. 2016.

Han L., Yanagawa Y. and Chan Y.S., A comparative study of intrinsic membrane properties between inhibitory and excitatory neurons in medial vestibular nucleus, Abstracts of 10^th FENS Forum of Neuroscience 277. [Copenhagen, Denmark. July 2-6, 2016]. 2016.

Han L. and Chan Y.S., Bidirectional action of 5-HT on synaptic transmission in rat medial vestibular nucleus, Frontiers in Cellular Neuroscience [14^th Meeting of Asian Pacific Society for Neurochemistry ]. 2016.

Hau W.F., Chan Y.S. and Shum D.K.Y., Sulfation patterns of chondroitins in the rat brainstem during development and vestibular compensation, Abstracts of 10^th FENS Forum of Neuroscience, 1771. [Copenhagen, Denmark. July 2-6, 2016]. 2016.

JIANG Q., Chen W., Shum D.K.Y. and Chan Y.S., Antidepressant Reinstates the Plasticity of Vestibular-mediated Navigation in the Adult, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

JIANG Q., Ma C.W., Shum D.K.Y. and Chan Y.S., Antidepressant reactivates the plasticity of vestibular-dependent navigation in the adult, Soc. Neuroscience Abstract (USA) , 264.14 [San Diego. Nov. 12-16, 2016]. 2016.

JIANG Q. and Chan Y.S., Antidepressant reinstates the plasticity of vestibular-mediated navigation in the adult. [Oral presentation at the Gordon Research Seminar on Molecular & Cellular Neurobiology – Novel Approaches & New Advancement in Neural Development, Plasticity, and Diseases June 11-12, 2016. 2016.

JIANG Q., Ma C.W., Shum D.K.Y. and Chan Y.S., Antidepressant reinstates the plasticity of vestibular-mediated navigation in the adult, Abstracts of 12^th Int’l Symp. on Healthy Aging: Science and Aging – Wellness and Longevity: From Science to Service: 61. [HK. March 11-12, 2017]. 2017.

JIANG Y., LAM T.F., Ma C.W., Shum D.K.Y., WANG J.J. and Chan Y.S., Modulatory role of orexin on synaptic transmission in the central vestibular system, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

JIANG Y., Lam T.F.U., Ma C.W., Shum D.K.Y., Wang J.J. and Chan Y.S., Modulatory role of orexin on synaptic transmission in the central vestibular system, Soc. Neuroscience Abstract (USA), 803.04 [San Diego. Nov. 12-16, 2016]. 2016.

JIANG Y., LAM T.F., Ma C.W., Shum D.K.Y., Wang J.J. and Chan Y.S., Orexin regulates synaptic transmission within the rat vestibular nucleus, Abstracts of 12^th Int’l Symp. on Healthy Aging: Science and Aging – Wellness and Longevity: From Science to Service : 64. [HK. March 11-12, 2017]. 2017.

KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Role of perineuronal chondroitin sulfates and semaphorin3A in the maturation of the vestibular circuitry, Abstracts of 10^th FENS Forum of Neuroscience, 2349. [Copenhagen, Denmark. July 2-6, 2016]. 2016.

Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Immobilised Chondroitinase ABC Promotes Axonal Regrowth in Lesioned Spinal Cord, 12^th International Symposium on Healthy Aging--Wellness and Longevity: From Science to Service. 2017, P9: 63.

Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Immobilised chondroitinase ABC promotes axonal regrowth in lesioned spinal cord, Abstracts of 12^th Int’l Symp. on Healthy Aging: Science and Aging Wellness and Longevity: From Science to Service : 63. [HK. March 11-12, 2017]. 2017.

LAM T.F., Ma C.W., Shum D.K.Y., Wang J.J. and Chan Y.S., Behavioral expression of orexin-modulated transmission in the vestibular nucleus of postnatal rats, Neuroscience 2016 of the Society for the Neurosciences. 2016.

LI Z., Chan Y.S. and Shum D.K.Y., Activity regulated neuronal trafficking of heparanase 1, Abstracts of 12^th Int’l Symp. on Healthy Aging: Science and Aging – Wellness and Longevity: From Science to Service : 50. [HK. March 11-12, 2017]. 2017.

LI Z., Chan Y.S. and Shum D.K.Y., Trafficking of Heparanase 1 is regulated by neuronal activity during homeostatic synaptic plasticity, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Lam T.F.U., Ma C.W., Shum D.K.Y., Wang J.J. and Chan Y.S., Behavioral expression of orexin-modulated transmission in the vestibular nucleus of postnatal rats, Soc. Neuroscience Abstract (USA), 803.09 [San Diego. Nov. 12-16, 2016]. 2016.

Leong T.L., Chan R.W., Gao P., Chan Y.S., Tsia K.K.M., Yung W.H. and Wu E.X., Long-range projections coordinate distributed brain-wide neural activity with a specific spatiotemporal profile, Proceedings of National Academy of Sciences USA. 2016, 113: E8306-8315.

Li B., Zhang X.Y., Yang A.H., Peng X.C., Chen Z.P., Zhou J.Y., Chan Y.S., Wang J.J. and Zhu J.N., Histamine increases neuronal excitability and sensitivity of the lateral vestibular nucleus and promotes motor behaviors via HCN channel coupled to H2 receptor, Frontiers Cellular Neuroscience. 2017, 10: 300.

Li C. and Chan Y.S., Otolith-related neurons in vestibulo-olivary-cerebellar pathway of rats, Abstracts of 10^th FENS Forum of Neuroscience, 452. [Copenhagen, Denmark. July 2-6, 2016]. 2016.

Li Y.H., Han L., Wu L.K. and Chan Y.S., Activation of 5-HT₇ receptors reverses NMDA receptor-dependent LTD by activating PKA at medial vestibular neurons, Neuropharmacology. 2017, 123: 242-248.

Shum D.K.Y., KWAN P.Y., Ma C.W. and Chan Y.S., The regulatory roles of perineuronal semaphorin 3A and chondroitin sulfates on the developing vestibular circuitry, Soc. Neuroscience Abstract (USA), 677.17 [San Diego. Nov. 12-16, 2016]. 2016.

Shum D.K.Y., Tsui Y.P., Cai S. and Chan Y.S., iPSC-derived sensory neurons for fate commitment of bone marrow-derived Schwann cells: Implication for re-myelination therapy, Frontiers in Cellular Neuroscience [14^th Meeting of Asian Pacific Society for Neurochemistry. Kuala Lumpur. August 27-30, 2016]. 2016.

Tsui Y.P., Wu L.K., Shum D.K.Y. and Chan Y.S., Cell therapy for CNS myelin disorders: Derivation of myelin-forming oligodendrocyte precursors from neural progenitors harbored by adult bone marrow stromal cells, Abstracts of 12^th Int’l Symp. on Healthy Aging: Science and Aging – Wellness and Longevity: From Science to Service: 81. [HK. March 11-12, 2017]. 2017.

Tsui Y.P., Mun K.L., Chan Y.S., Shum D.K.Y. and Shea G.K.H., Hypoxic preconditioning of marrow-derived progenitor cells as a source for the generation of mature Schwann cells, J. Visualized Experiments. 2017, 124.

Tsui Y.P., Tam K.W., Shum D.K.Y. and Chan Y.S., Schwann cells demonstrated lineage plasticity in culture and acquired oligodendrocyte phenotypes, International Society for Stem Cell Research Annual Meeting 2016.

Wong E., Yang B., Du L., Ho W.H., Lau C., Ke Y., Chan Y.S., Yung W.H. and Wu E.X., The multi-level impact of chronic intermittent hypoxia on central auditory processing, Neuroimage. 2017, 156: 232-239.

Wu K.L., Shum D.K.Y. and Chan Y.S., Neuron-astrocyte signaling in perineuronal net formation, Abstracts of 10^th FENS Forum of Neuroscience, 3475. [Copenhagen, Denmark. July 2-6, 2016]. 2016.

Wu L.K., Shum D.K.Y. and Chan Y.S., Neuron-astrocyte signaling In perineuronal net formation, 10^th FENS Forum of Neuroscience (FENS 2016). 2016.

Zhang H.Q., Zhang Y., Liu L., Li J.L., Lu Y.C., Yu Y.Y., Li H., Zhang T., Chan Y.S., Zhang F.X. and Li Y.Q., Neural connection supporting endogenous 5-hydroxytryptamine influence on autonomic activity in medial prefrontal cortex, Autonomic Neuroscience – Basic & Clinical. 2017, 203: 25-32.

Researcher : Chang RCC

Project Title:	Significance of molecular signaling for protein translation control in neurodegeneration of amyotrophic lateral sclerosis
Investigator(s):	Chang RCC
Department:	School of Biomedical Sciences
Source(s) of Funding:	Liu Po Shan/Dr Vincent Liu Endowment Fund for Motor Neuron diseases - General Award
Start Date:	03/2008

Project Title:	Elucidating pathological mechanisms of visual impairment in the pathogenesis of Alzheimer’s disease: from basic science to innovative approach of disease monitoring (CRF)
Investigator(s):	Chang RCC
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Funding for Incubating Group-based Collaborative Research Projects
Start Date:	01/2015
Completion Date:	12/2016

Project Title:	Elucidating the molecular defects associated with PTEN mutations in Autism Spectrum Disorders
Investigator(s):	Chang RCC
Department:	School of Biomedical Sciences
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	04/2015

Project Title:	Advancement for developing drug against Lewy Body Dementia by establishing a pre-clinical experimental model
Investigator(s):	Chang RCC, Ho YS, Ng TW, Chu MT
Department:	Anatomy
Source(s) of Funding:	Seed Fund for Translational and Applied Research
Start Date:	04/2015
Completion Date:	12/2016

Project Title:	Investigating oxyresveratrol as potential neuroprotective drug in experimental models of Parkinson’s disease
Investigator(s):	Chang RCC, Ng KM, Wang M, Ho YS
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2015

Project Title:	Investigation of drugs targeting mitochondrial dynamics and reactive oxygen species for Parkinson’s disease treatment using in vitro and in vivo imaging models
Investigator(s):	Chang RCC, Hung HLC
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2015

Project Title:	Investigating the significance of JNK3 and PKR in modulating the fate of neurons in cigarette smoking-induced neurodegeneration as risk factor of Alzheimer's disease
Investigator(s):	Chang RCC, Ho YS
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2016

Project Title:	Establishment of pre-clinical platform and a novel 3D tissue visualisation protocol for therapeutic drug development of Lewy Body Dementias
Investigator(s):	Chang RCC
Department:	School of Biomedical Sciences
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	09/2016

Project Title:	Society for Neuroscience 2016; Development of tissue clearing techniques for the visualisation of neurodegenerative pathology in three-dimensions
Investigator(s):	Chang RCC
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2016
Completion Date:	11/2016

Project Title:	Significance of frontal cortex in the progression of Alzheimer’s disease
Investigator(s):	Chang RCC, Ho YS
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

List of Research Outputs

Chang R.C.C., Co-Chairman, International Alzheimer's Disease Conference, HKU Alzheimer's Disease Research Network. 2017.

Chang R.C.C., YOU R., Hung H.L.C. and Ho Y.S., Environmental pollutants as risk factos for developing cognitive dysfunctions and Alzheimer’s disease. , The 10th Annual Scientific Meeting of Hong Kong Society of Biological Psychiatry: Brain and the Environment II. . 2017, 13.

Chang R.C.C., HUANG C. and Wong G.T.C., Impact of systemic inflammation on neuroinflammation, cognitive functions and phosphorylation of tau by laparotomy. Implication of postoperative cognitive dysfunctions to Alzheimer’s dementia., The 13th International Conference on Alzheimer’s & Parkinson’s Diseases 2017, Section B01.c Disease mechanisms, pathophysiology: Inflammation. 2017, 165.

Chu M.T., Ho Y.S., Wong G.T.C. and Chang R.C.C., Aerobic training increased FGF21 expression and attenuated cognition in Alzheimer’s disease mice. , International Alzheimer’s Disease Conference 2017. 42.

Gentleman S., Goldfinger M.E.D., Chang R.C.C., Lai H.M. and LIU K.L., Next generation histology pipeline for three-dimensional visualization of archival chronic traumatic encephalopathy brain tissues, The 13th International Conference on Alzheimer’s & Parkinson’s Diseases 2017, Section B01.a Disease mechanisms, pathophysiology: tau aggregation, phosphorylation, acetylation & modifications. . 2017, 128.

HUANG C., LIU Y., Chu M.T., Chang R.C.C. and Wong G.T.C., The effect of varenicline on DNA damage and tau mislocalization in the cognitive impairment induced by laparotomy., International Alzheimer’s Disease Conference 2017. 39.

LIU K.L., Lai H.M., Chang R.C.C. and Gentleman S.M., Free-of-acrylamide SDS-based Tissue Clearing (FASTClear): A novel protocol of tissue clearing for three-dimensional visualisation of human brain tissues., Neuropathol. Appl. Neurobiol.,. 2017, 43: 346-351.

LIU Y., HUANG C., Chang R.C.C. and Wong G.T.C., Correlation between cognition enhancement and synaptic protein variation during prolonged sevoflurane exposure., International Alzheimer’s Disease Conference 2017. 42.

Manthey A.L., Chang R.C.C., So K.F. and Chiu K., Can regular retinal checkups be used to diagnose, monitor, and study Alzheimer’s disease pathogenesis in Hong Kong? , The International Conference of Vision and Eye Research (iCOVER) . 2017.

PANG C.C.C., Man S.C., Lee K., Noble W. and Chang R.C.C., Establishing a pre-clinical therapeutic platform to screen for dementia therapeutics. , International Alzheimer’s Disease Conference 2017. 41.

PANG C.C.C. and Chang R.C.C., Investigating tau and alpha-synuclein in Parkinson’s disease dementia model., The 13th International Conference on Alzheimer’s & Parkinson’s Diseases 2017, Section B01.a Disease mechanisms, pathophysiology: tau aggregation, phosphorylation, acetylation & modifications. . 2017, 137.

PANG C.C.C., Noble W. and Chang R.C.C., Investigating the impacts of Parkinson’s Disease Dementia (PDD) by using an animal model in PD, 4th International Anatomical Sciences & Cell Biology Conference. 2016.

PANG C.C.C., Man S.C., Nobel W. and Chang R.C.C., Investigating the impacts of Parkinson’s disease dementia (PDD) by using an animal model in PDThe 12th International Symposium on Healthy Aging, The 12th International Symposium on Healthy Aging. 2017, 64.

SHAH A.N., Hung H.L.C., Cheng S.Y., WONG M.Y., Legido-Quigley C. and Chang R.C.C., Oxyresveratrol mitigates cellular toxicity in and in-vitro and in-vivo model of Parkinson’s disease, The 13th International Conference on Alzheimer’s & Parkinson’s Diseases 2017, Section C02.g Therapeutic targets, mechanisms for treatment: anti- inflammatory, anti-oxidant.. 2017, 146.

WONG M.Y., SHAH A.N., CHENG S.Y. and Chang R.C.C., Effects on Oxyresveratrol on Motor and Cognitive Functions in 6-OHDA-Induced Parkinson’s Disease, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

WONG M.Y., SHAH A.N. and Chang R.C.C., Protective effects of oxyresveratrol on motor functions in 6-OHDA-Induced neurodegeneration, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

WONG M.Y., SHAH A.N. and Chang R.C.C., Protective effects of oxyresveratrol on motor functions in 6-OHDA-induced neurodegeneration. , The 12th International Symposium on Healthy Aging. 2017, 79.

YOU R., Ho Y.S., Hung H.L.C. and Chang R.C.C., Evaluating the implication of silica nanoparticles in neurodegeneration, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

YOU R., Hung H.L.C., Ho Y.S. and Chang R.C.C., Investigating the effects of silica nanoparticles on neurodegeneratioive-like changes in behaviors and neuropathology. , International Alzheimer’s Disease Conference 2017. 40.

YOU R., Ho Y.S., Hung H.L.C., Lai S.W.C. and Chang R.C.C., Investigating the effects of slicia nanoparticles as affective and cognitive behaviors. , The 12th International Symposium on Healthy Aging. 2017, 50.

Yu S., Tang X., Ho Y.S., Chang R.C.C. and Chiu K., Links between the brain and retina: the effects of cigarette smoking-induced age-related changes in Alzheimer’s disease and macular degeneration., Frontiers in Neurology. 2016, 7: 119.

Zhang F., Zhong R., Li S., Chang R.C.C. and Le W., The missing link between sleep disorders and age-related dementia: recent evidence and plausible mechanisms, J. Neural Transm. 2017, 124: 559-568.

Zhang Y.L., Xing R.Z., Luo X.B., Xu H.M., Chang R.C.C., Zou L.Y., Liu J.J. and Yang X.F., Anxiety-like behavior and dysregulation of miR-34a in triple transgenic mice of Alzheimer’s disease., European Review for Medical and Pharmacological Sciences. 2016, 20: 2853-2862.

Researcher : Chaudhary V

List of Research Outputs

CHAUDHARY V. and Jin D., American Society for Virology Student Travel Award 2017, American Society for Virology. 2017.

CHAUDHARY V., Reaching Out Award 2017, HKSAR Government Scholarship Fund. 2017.

CHAUDHARY V., Tigris Educational Fund - Graduate Student Travel Scholarship 2017, Tigris Educational Fund. 2017.

Researcher : Cheah KSE

Project Title:	Defining the role of the transcription factor Sox9 in skeletal development by tissue-specific gene inactivation
Investigator(s):	Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	UK/Hong Kong Joint Research Scheme
Start Date:	02/1998

Project Title:	4th Pan-Pacific Connective Tissues Societies Symposium Abnormal Regulation of Cartilage and Bone Growth in Transgenic Mice Expressing a Collagen X SMCD Mution
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/1999

Project Title:	Human Genome Meeting 2001 Genomic Analysis of the Mutant Locus in the Novel Transgenic Mouse Mutant, Yellow Submarine (ysb)
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2001

Project Title:	67th Cold Spring Harbor Symposium on Quantitative Biology - The Cardiovascular System An Essential Role for Type IIA Procollagen in Heart Development
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2002

Project Title:	1st Annual Meeting of the American Society for Matrix Biology Type IIA Procollagen is Essential for Proper Heart Development
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2002

Project Title:	The Gordon Research Conference on Cartilage Biology and Pathology Chondrocytes Survive ER Stress Caused by Unfolded Proteins and Differentiation is Re-programmed
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2005

Project Title:	11th Human Genome Meeting Procollagen IIA Facilitates BMP Signaling in Heart Development
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2006

Project Title:	Cold Spring Harbor Laboratory Meeting on Mouse Molecular Genetics Insight into the Molecular Pathogenesis of Campomelic Dysplasia Received By A Conditional SOX9 Mutant Mouse Model
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2006

Project Title:	Role of Sox2 in the stemness of dermal precursors
Investigator(s):	Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2010

Project Title:	Functional analyses of how genomic variation affects personal risk for degenerative skeletal disorders
Investigator(s):	Cheah KSE, Chan BP, Chan D, Cheung KMC, Jin D, Lian Q, Luk KDK, Sham PC, Zhang MQ, Cherny SS, Huang J, Ng RK, Samartzis D, Song Y, Wang JJ
Department:	School of Biomedical Sciences
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	01/2013

Project Title:	Genetic analyses of the roles of Sox2 and Sox18 in hair follicle development
Investigator(s):	Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013
Completion Date:	01/2018

Project Title:	Development and Reproduction
Investigator(s):	Cheah KSE, Ng EHY, Wu EX
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	06/2013

Project Title:	Identifying critical transitions and gene regulatory networks controlling phases of chondrocyte differentiation in the growth plate
Investigator(s):	Cheah KSE, Wang JJ, Chan D, Ng RK
Department:	School of Biomedical Sciences
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2014

Project Title:	Mechanistic insights into the genesis and physiological role of hypertrophic chondrocyte-derived osteoblasts
Investigator(s):	Cheah KSE, Chan D
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014

Project Title:	Craniofacial Morphogenesis & Tissue Regeneration; Transcriptional control of sensory progenitor specification in the inner ear
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2014

Project Title:	Mechanisms controlling determination of sensory versus non-sensory fate in inner ear development
Investigator(s):	Cheah KSE, Wong YME, Jin D
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2014

Project Title:	Global Spine Congress 2015; The changing RNAome of the developing nucleus pulposus of the intervertebral disc - implications for Intervertebral Disc Disease
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2015

Project Title:	Gordon Research Conference on Bones and Teeth; Dissecting the transition from hypertrophic chondrocyte to osteoblast in skeletal development and growth
Investigator(s):	Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	02/2016

Project Title:	Gordon Research Conference - 2017 Neural Crest & Cranial Placodes; Impact of Sox2 dosage on sensory neurogenesis and prosensory versus non-sensory cell fate in the inner ear
Investigator(s):	Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	02/2017

List of Research Outputs

Burns A.J., Goldstein A.M., Newgreen D.F., Stamp L., Schafer K.H., Metzger M., Hotta R., Young H.M., Andrews P.W., Thapar N., Belkind-Gerson J., Bondurand N., Bornstein J.C., Chan W.Y., Cheah K.S.E., Gershon M.D., Heuckeroth R.O., Hofstra R.M.W., Just L., Kapur R.P., King S.K., McCann C.J., Nagy N., Ngan E.S.W., Obermayr F., Pachnis V., Pasricha P.J., Sham M.H., Tam P.K.H. and Vanden Berghe P., White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies, Developmental Biology. 2016, 417(2): 229-251.

CHU T.L., Tsang K.Y., Tsang S.W., Zhou Z. and Cheah K.S.E., MMP14 Regulates Lineage Progression of Hypertrophic Chondrocytes, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

CHU T.L., Tsang K.Y., Zhou Z. and Cheah K.S.E., MMP14 and Regulation of the Hypertrophic Chondrocyte to Osteoblast Lineage, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Cheah K.S.E., Chondrocyte Plasticity and Fate Determination in Development and Disease, Gordon Research Conference on Cartilage Biology & pathology. Gordon Research Conference on Cartilage Biology & Pathology. Lucca (Barga), Italy. April 2-7, 2017.. 2017.

Cheah K.S.E., Chondrocyte plasticity, adaptation and survival under ER stress., 9th International Conference on Stem Cell and Regenerative Medicine, December 20- 21, 2016, Guangzhou, PR China. 2016.

Cheah K.S.E., Leung K.K.H., Tam A., Kwong M., Pelling A., Jahan I. and Lovell-Badge R.H., Impact of Sox2 dosage on sensory neurogenesis and prosensory versus non-sensory cell fate in the inner ear., Gordon Research Conference - 2017 Neural Crest & Cranial Placodes, Ventura, USA. February 5-10, 2017. . 2017.

Cheung M.C.H., RAO Y., Cheung M.P.L., Sharma R. and Cheah K.S.E., Asymmetric localization of Dlc1 defines trunk neural crest polarity for directional delamination and migration, International Congress of Developmental Biolog. Elsevier, 2017, 145: S65.

QIN Y., Ng R.K., Ng T.W., Tong K.K., Au Y.K., Niu B., Tan Z., Yip M.S., Wang J.J., Sham P.C. and Cheah K.S.E., Genome-wide identification of active enhancers in the developing mouse nucleus pulposus, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

SO K.H., Kudelko M.A., Tan Z., Wang C., Chan W.C.W., Tsang K.Y., Cheah K.S.E. and Chan D., FGF21 Up-Regulates Glycolytic Proteins for Hypertrophic Chondrocyte Survival under ER Stress, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Tai C.P., Cheung M.C.H., Huang Y.H., Jauch R., Bronner M.E. and Cheah K.S.E., SOXE neofunctionalization and elaboration of the neural crest during chordate evolution, Scientific Reports. 2016, 6: 34964.

Tsang K.Y., Li X.Y., Wu M.H., Jin G., Chan D., Zhang M.Q. and Cheah K.S.E., Single cell transcriptomes reveal a mesenchymal state during chondrocyte to osteoblast transition., Keystone Symposium Single Cell Omics, May 26-30, 2017, Stockholm. 2017.

Wang Y., Wu M.H., Cheung M.P.L., Sham M.H., Haruhiko A., Chan D., Cheah K.S.E. and Cheung M.C.H., Reprogramming of Dermal Fibroblasts into Osteo-Chondrogenic Cells with Elevated Osteogenic Potency by Defined Transcription Factors, Stem Cell Reports. 2017, 8: 1587-1599.

YU Z., TANG L.F., WANG J., Bao S., SHIEH J.T., LEUNG A.W.L., Gao F., ZHANG Z., WONG S.Y.Y., HUI A.L.C., Dung W.F., ZHANG Z., Fan Y., Wong S.M., Sham P.C., AZHAR A., KWOK P.Y., TAM P.P.L., Lian Q. and Cheah K.S.E., Hnrnpa1 Mutations Cause Congenital Heart Defects, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

ZHANG C., LIM F.L., Tam W.K., Au Y.K., Cheah K.S.E., Cheung K.M.C. and Leung V.Y.L., Development of Intervertebral disc degeneration in N-cadherin mutant mouse, Gordon Research Conference: Cartilage Biology & Pathology, Lucca. 2017.

ZHANG C., LIM F.L., Tam W.K., Au Y.K., Cheah K.S.E., Cheung K.M.C. and Leung V.Y.L., Development of lumbar disc degeneration in cadherin 2 mouse mutant, The Annual Meeting of the International Society for the Study of the Lumbar Spine, Athens. 2017.

Zhang Y., ZHANG Z., Cheah K.S.E. and Lian Q., Developing Strategies to Produce Notochord Like Cells from Human ESC/iPSC, ISSCR 2017 Annual Meeting. 2017.

Researcher : Chen J

Project Title:	CFTR Activation by Regional Phosphorylation on the R Domain
Investigator(s):	Chen J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	09/2013
Completion Date:	08/2016

Project Title:	Investigating the molecular mechanisms how ΔF508 mutation delays phosphorylation-dependent CFTR activation
Investigator(s):	Chen J
Department:	School of Biomedical Sciences
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2014

Project Title:	Molecular mechanisms of bicarbonate transport and impaired pH sensitivity in ΔF508-CFTR
Investigator(s):	Chen J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2015
Completion Date:	02/2017

Project Title:	Molecular mechanisms of bicarbonate transport and impaired pH sensitivity in ΔF508-CFTR
Investigator(s):	Chen J, Chan YS
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2015

Project Title:	Investigating the mechanisms how Pseudomonas aeruginosa affects the function of airway epithelia
Investigator(s):	Chen J, Li NF, Wong PF
Department:	School of Biomedical Sciences
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2016

Project Title:	Regional function around the F508 residue in protein processing and channel gating of CFTR
Investigator(s):	Chen J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2016

Project Title:	Investigating the molecular mechanisms how Pseudomonas aeruginosa infection enhances the permeability of airway epithelia.
Investigator(s):	Chen J, Yan A
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2017

Project Title:	14th ECFS Basic Science Conference ; The processing defect of ΔF508- and ΔY512-CFTR are generated by similar mechanisms with different initial flaws
Investigator(s):	Chen J
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2017
Completion Date:	04/2017

List of Research Outputs

Researcher : Chen J

List of Research Outputs

Researcher : Chen S

List of Research Outputs

XIONG G., Chen S. and Lin B., Prolong the Survival of Photoreceptors by Modulating the Apoptosis Pathway in a Mouse Model of Retinitis Pigmentosa, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

Researcher : Chen W

List of Research Outputs

JIANG Q., Chen W., Shum D.K.Y. and Chan Y.S., Antidepressant Reinstates the Plasticity of Vestibular-mediated Navigation in the Adult, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : Cheng SY

List of Research Outputs

Researcher : Cheng WH

List of Research Outputs

Cheng W.H., Chung W.H. and NG J.C.F., Structural Dynamics of Amyloid-β Aggregation in Alzheimer’s Disease: Computational and Experimental Approaches, Journal of Young Investigators. 2016.

TONG C.K.B., LEE S.K., CHENG W.H., Lai K.O., Foskett J.K. and Cheung K.H., Familial Alzheimers disease-associated presenilin 1 mutants promote γ-secretase cleavage of STIM1 to impair store-operated Ca2+ entry, Science Signaling. 2016, 9: ra89.

Researcher : Cheung A

Project Title:	Identification of miR-29c/FBXO31 as a key regulatory mechanism in esophageal cancer chemoresistance-functional validation and implication for therapy
Investigator(s):	Cheung A, Li B
Department:	School of Biomedical Sciences
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2015

Project Title:	Role of miR-338-5p as a novel modulator of chemoresistance in esophageal cancer
Investigator(s):	Cheung A, Chan KW, Law SYK, Tsao GSW
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	miR-338-5p suppresses esophageal cancer invasion and metastasis through direct targeting of Id1 and PAK4
Investigator(s):	Cheung A, Chan KW, Tsao GSW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

Project Title:	Role and mechanism of serglycin in promoting esophageal cancer invasion and metastasis
Investigator(s):	Cheung A, Chan KW, Tsao GSW, Law SYK
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2016

Project Title:	24th Biennial Congress of the European Association for Cancer Research; miR-29c modulates chemoresistance in esophageal cancer cells by suppressing FBXO31
Investigator(s):	Cheung A
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2016
Completion Date:	07/2016

List of Research Outputs

Cheung A., Li B., Xu W., Liu J. and Chan K.W., miR-29c modulates chemoresistance in esophageal cancer cells by suppressing FBXO31, European Journal of Cancer (24th Biennial Congress of the European Association for Cancer Research). 2016, 61 Suppl 1: S64.

Fung T.M., Ng K.Y., Tong M., CHEN J., Chai S., Chan K.T., Law S.Y.K., Lee N.P.Y., Choi M.Y., Li B., Cheung A., Tsao G.S.W., Qin Y.R., Guan X., Chan K.W. and Ma S.K.Y., Neuropilin-2 promotes tumourigenicity and metastasis in oesophageal squamous cell carcinoma through ERK-MAPK-ETV4-MMP-E-cadherin deregulation, Journal of Pathology. 2016, 239(3): 309-319.

Li B., XU W., Lam A.K.Y., Wang Y.A.N.G., Hu H.-.F., Guan X., Qin Y.R., Saremi N., Tsao G.S.W., He Q.-.Y. and Cheung A., Significance of PI3K/AKT signaling pathway in metastasis of esophageal squamous cell carcinoma and its potential as a target for anti-metastasis therapy, Oncotarget. 2017, 8: 38755-38766.

XU W., Li B., Guan X., Chung S.K., Yang W., Yip Y.L., Law S.Y.K., Chan K.T., Lee N.P.Y., Chan K.W., Xu L.Y., Li E.M., Tsao G.S.W., He Q.Y. and Cheung A., Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression, Nature Communications. 2017, 8: 14399.

ZHANG J., Jia L.J., Lin W., Yip Y.L., LAU V.M.-.Y., Zhu D., Tsang C.M., Zhou Y.L., Deng W., Lung H.L., Lung M.L., Cheung A. and Tsao G.S.W., Epstein-Barr Virus Encoded Latent Membrane Protein-1 Induces Glucose Transporter-1 Transcription is Dependent on the mTORC1 Mediated NF-κB Pathway Activation, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

Researcher : Cheung KH

Project Title:	Nuclear Membrane Electrophysiology of Ryanodine Receptor And Its Regulation by cADPR
Investigator(s):	Cheung KH, Chen J
Department:	Physiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2013
Completion Date:	02/2017

Project Title:	Electrophysiological Characterization of the Two-Pore Channel 2
Investigator(s):	Cheung KH
Department:	Physiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2014
Completion Date:	02/2017

Project Title:	Role of TMEM16A in the formation of epididymal microenvironment
Investigator(s):	Cheung KH
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2015

Project Title:	Role of presenilin-1 in pancreatic beta-cell insulin secretion
Investigator(s):	Cheung KH
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

List of Research Outputs

DONG R., Tong C.K.B. and Cheung K.H., Impaired Ca2+ Homeostasis in Lysosome Caused by FAD-linked Presenilin-1 Mutation is Responsible for Autophagy Defection in Familial Alzheimer’s Disease, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

DONG R., TONG C.K.B. and Cheung K.H., Lysosomal Ca2+ disruption induces autophagy impairment in familial Alzheimer’s disease, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

TONG C.K.B., LEE S.K., CHENG W.H., Lai K.O., Foskett J.K. and Cheung K.H., Familial Alzheimers disease-associated presenilin 1 mutants promote γ-secretase cleavage of STIM1 to impair store-operated Ca2+ entry, Science Signaling. 2016, 9: ra89.

Wang Q., Guo W., Hao B., Shi X., Lu Y., Wong W.M., Ma V.W., Yip T.T., Au S.K., Hao Q., Cheung K.H., Wu W., Li G.R. and Yue J., Mechanistic study of TRPM2-Ca 2+ -CAMK2-BECN1 signaling in oxidative stress-induced autophagy inhibition , Autophagy. 2016, 12: 1340-1354.

Researcher : Cheung MCH

Project Title:	In vivo functional characterization of a Rho GTPase-activating protein, DLC1, in neural crest development
Investigator(s):	Cheung MCH
Department:	School of Biomedical Sciences
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	10/2014

Project Title:	Elucidating the contribution of cross-regulatory interactions between SOX9 and SOX10 to melanoma progression
Investigator(s):	Cheung MCH, Lung HL
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	03/2015
Completion Date:	08/2016

Project Title:	Elucidating the role of Sox9 in cell fate acquisition of neural crest progenitors in the dorsal root ganglia
Investigator(s):	Cheung MCH, Sham MH, Lui VCH, Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2015

Project Title:	Elucidating the role of Dlc1beta in motor neuron development
Investigator(s):	Cheung MCH
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2016

Project Title:	Elucidating the therapeutic potential of neural stem cells with genetic manipulation of Sox9 expression following spinal cord injury
Investigator(s):	Cheung MCH, Wu W, Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2016

Project Title:	Elucidating the role of Deleted in Liver Cancer-1 (DLC1) in melanoma development and therapy
Investigator(s):	Cheung MCH, Guan X
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2017

List of Research Outputs

Carrasco-Garcia E., Lopez L., Aldaz P., Arevalo S., Aldaregia J., Egana L., Bujanda L., Cheung M.C.H., Sampson N., Garcia I. and Math A., Sox9-regulated cell plasticity in colorectal metastasis is attenuated by rapamycin, Scientific Reports. Nature, 2016, In press.

Cheung M.C.H., Asymmetric localisation of DLC1 defines neural crest polarity for directional migration, 4th International Anatomical Sciences and Cell Biology Conference (IASCBC 2016). 2016.

Cheung M.C.H., Asymmetric localisation of DLC1 defines trunk neural crest polarity for directional delamination and migration, Department of Anatomy Yong Loo Lin School of Medicine, National University of Singapore. 2017.

Cheung M.C.H., RAO Y., Cheung M.P.L., Sharma R. and Cheah K.S.E., Asymmetric localization of Dlc1 defines trunk neural crest polarity for directional delamination and migration, International Congress of Developmental Biolog. Elsevier, 2017, 145: S65.

Cheung M.C.H., Molecular regulation of neural crest development and melanoma metastasis, 2015 Recent Trends in Advanced Cancer Prevention (Oct. 23-24 2015). 2016.

LI T., Zheng F., Cheung M.C.H., WANG F. and Fu C., Fission yeast mitochondria are distributed by dynamic microtubules in a motor-independent manner, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Liu A.J. and Cheung M.C.H., Neural crest stem cells and their potential therapeutic applications, Developmental Biology. 2016, 419: 199-216.

RAO Y., Liu A.J., Cheung M.P.L. and Cheung M.C.H., Dlc1, a Rho GTPase-activating protein, is essential for cranial neural crest development, 4th International Anatomical Sciences & Cell Biology Conference. 2016.

Tai C.P., Cheung M.C.H., Huang Y.H., Jauch R., Bronner M.E. and Cheah K.S.E., SOXE neofunctionalization and elaboration of the neural crest during chordate evolution, Scientific Reports. 2016, 6: 34964.

Wang Y., Wu M.H., Cheung M.P.L., Sham M.H., Haruhiko A., Chan D., Cheah K.S.E. and Cheung M.C.H., Reprogramming of Dermal Fibroblasts into Osteo-Chondrogenic Cells with Elevated Osteogenic Potency by Defined Transcription Factors, Stem Cell Reports. 2017, 8: 1587-1599.

YANG X., Cheung M.P.L., Liang R. and Cheung M.C.H., Elucidating the role of DLC1 in Metastatic Melanoma, 4th International Anatomical Sciences & Cell Biology Conference. 2016.

Researcher : Cheung MPL

List of Research Outputs

Cheung M.C.H., RAO Y., Cheung M.P.L., Sharma R. and Cheah K.S.E., Asymmetric localization of Dlc1 defines trunk neural crest polarity for directional delamination and migration, International Congress of Developmental Biolog. Elsevier, 2017, 145: S65.

RAO Y., Liu A.J., Cheung M.P.L. and Cheung M.C.H., Dlc1, a Rho GTPase-activating protein, is essential for cranial neural crest development, 4th International Anatomical Sciences & Cell Biology Conference. 2016.

Wang Y., Wu M.H., Cheung M.P.L., Sham M.H., Haruhiko A., Chan D., Cheah K.S.E. and Cheung M.C.H., Reprogramming of Dermal Fibroblasts into Osteo-Chondrogenic Cells with Elevated Osteogenic Potency by Defined Transcription Factors, Stem Cell Reports. 2017, 8: 1587-1599.

YANG X., Cheung M.P.L., Liang R. and Cheung M.C.H., Elucidating the role of DLC1 in Metastatic Melanoma, 4th International Anatomical Sciences & Cell Biology Conference. 2016.

Researcher : Cheung WTL

Project Title:	PIK3R2 amplification in ovarian cancer: functional significance and implication for cancer therapy.
Investigator(s):	Cheung WTL
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

Project Title:	Targeting PIK3R1 copy number loss in ovarian cancer
Investigator(s):	Cheung WTL
Department:	School of Biomedical Sciences
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	01/2017

Project Title:	Characterization of PIK3R1 nSH2 domain mutations in cancer
Investigator(s):	Cheung WTL
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2017

Project Title:	Exploiting synthetic lethal interactions with EGFR inhibitor for translation to cancer therapies
Investigator(s):	Cheung WTL
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Translational and Applied Research
Start Date:	04/2017

List of Research Outputs

Cheung W.T.L., Approaches for functional genomics., Big data at the heart of 21st Century Research, Edinburgh, Scotland.. 2016.

Cheung W.T.L., Functional Genomic Strategies for Cancer Biology and Precision Cancer Therapy, School of Biomedical Sciences Seminar. 2016.

Cheung W.T.L., Phenotypic spectrum of PIK3R1 mutations in cancers., The 4th International Anatomical Sciences & Cell Biology Conference. 2016.

Cheung W.T.L., The identification of clinically actionable genes for precision cancer medicine., 12th International Symposium on Healthy Aging. 2017.

Cheung W.T.L., The identification of clinically actionable genes for precision cancer medicine., 12th International Symposium on Healthy Aging "Wellness and Longevity: From Science to Service", Hong Kong. 2017.

Cheung W.T.L., Travel award, U21 Workshop for Early Career Researchers, Universitas 21 (U21) and HKU. 2016.

Takiar V., Ip C.K.M., Gao M., Mills G.B. and Cheung W.T.L., Neomorphic mutations create therapeutic challenges in cancer, Oncogene. 2017, 36: 1607-1618.

Researcher : Cheung YW

List of Research Outputs

Cheung Y.W., SHIU C.C., FRASER L.A., LIANG S., Dirkzwager R.M., Kinghorn A.B., TANG S.L.M. and Tanner J.A., Aptamer-mediated biosensing: from malaria diagnosis to DNA nanostructure dynamics, 5th International Conference on Bio-Sensing Technology. 2017.

Cheung Y.W., DIRKZWAGER R.M., FRASER L.A., Richards J.S. and Tanner J.A., DNA aptamer targeting Plasmodium falciparum histidine rich protein 2: Development of aptamer—antibody sandwich assay for malaria rapid diagnosis, International Congress for Tropical Medicine and Malaria. 2016.

Cheung Y.W. and Tanner J.A., Development of sandwich aptamer-based lateral flow strip tests for Plasmodium specific malaria diagnosis, 4th Oxford Symposium on Aptamers. 2017.

Cheung Y.W., SHIU C.C., Wong W.C., TANG S.L.M., DIRKZWAGER R.M., LIANG S., KINGHORN A.B., FRASER L.A. and Tanner J.A., From DNA aptamer structure to splitting for use in DNA nanotweezers, Oligo 2017 Oxford: Antisense & Therapeutic Nucleic Acids. 2017.

FRASER L.A., Kinghorn A.B., Dirkzwager R.M., Cheung Y.W., Richards J. and Tanner J.A., 3D Printed Microfluidics for Point of Care Malaria Diagnosis, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

KINGHORN A.B., DIRKZWAGER R.M., LIANG S., Cheung Y.W., FRASER L.A., SHIU C.C., TANG S.L.M. and Tanner J.A., Aptamer Affinity Maturation by Resampling and Microarray Selection, Analytical Chemistry. American Chemical Society, 2016, 88: 6981-6985.

SHIU C.C., Cheung Y.W., DIRKZWAGER R.M., LIANG S., Kinghorn A.B., FRASER L.A., TANG S.L.M. and Tanner J.A., A split aptamer can facilitate protein recognition in DNA nanotweezers, Aptamers 2017, 4th Oxford Symposium on Aptamers. 2017.

SHIU C.C., Cheung Y.W., LIANG S., Kinghorn A.B., LIANG S., TANG S.L.M. and Tanner J.A., An Aptamer-Mediated DNA Nano-Switch, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

SHIU C.C., Cheung Y.W., DIRKZWAGER R.M., LIANG S., Kinghorn A.B., FRASER L.A., TANG S.L.M. and Tanner J.A., Aptamer-Mediated Protein Molecular Recognition Driving a DNA Tweezer Nanomachine, Advanced Biosystems. 2017, 1: 1600006.

SHIU C.C., Cheung Y.W., Dirkzwager R.M., LIANG S., Kinghorn A.B., FRASER L.A., Tang S.L.M. and Tanner J.A., DNA Tweezer Nanomachine Mediated by Heterogeneous Recognition, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

SHIU C.C., TANG S.L.M., DIRKZWAGER R.M., LIANG S., Kinghorn A.B., Cheung Y.W., FRASER L.A., Godonoga M., Heddle J.G. and Tanner J.A., Protein driven aptamer toehold switches integrated into DNA origami nanostructures, Oligo 2017 Oxford: Antisense & Therapeutic Nucleic Acids. 2017.

Wang W.X., Cheung Y.W., DIRKZWAGER R.M., Wong W.C., Tanner J.A., Li H.W. and Wu Y., Specific and sensitive detection of Plasmodium falciparum lactate dehydrogenase by DNA-scaffolded silver nanoclusters combined with an aptamer, The Analyst. 2017, 142: 800-807.

Researcher : Ching YP

Project Title:	Roles of p21-activated protein kinase (Pak) 1 in the pathogenesis of liver cancer
Investigator(s):	Ching YP, Ng IOL, Jin D, Yau TO
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2006

Project Title:	HBx oncoprotein induces chromosome instability in hepatocarcinogenesis via dysregulation of centrosome duplication regulatory protein, TAX1BP2
Investigator(s):	Ching YP, Jin D
Department:	Anatomy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2013
Completion Date:	10/2016

Project Title:	Functional characterization of the roles of NIMA-related kinase, Nek2 in liver cancer development and metastasis
Investigator(s):	Ching YP, Chung SK
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	The therapeutic potential of Polo-like protein kinase 4 in liver cancer
Investigator(s):	Ching YP
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2015
Completion Date:	03/2017

Project Title:	A study of the role of CDK5RAP3 in neuronal cell differentiation
Investigator(s):	Ching YP, Chang RCC
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2015

Project Title:	Functional characterization of the roles of Polo-like kinase 4, Plk4 in hepatocarcinogenesis
Investigator(s):	Ching YP
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016

Project Title:	Characterization of novel HBx regulated gene in hepatocellular carcinoma
Investigator(s):	Ching YP
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2016

Project Title:	A study of the role of p21-activated kinase 4 (PAK4) in chromosome instability
Investigator(s):	Ching YP
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2017

List of Research Outputs

CHAN S.H.V. and Ching Y.P., The role of Nek2 in hepatocellular carcinoma, 2017 AACR Annual meeting. D.C. Washington, USA, 2017.

CHAN S.H.V. and Ching Y.P., The role of Nek2 in hepatocellular carcinoma, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Li S.K., Tang H.C., Lau P.Y., Zhou Y. and Ching Y.P., HBx oncoprotein induces chromosome instability in hepatocarcinogenesis via dysregulation of putative tumor suppressor, TAX1BP2, Health Research Symposium 2017.

Ng K.Y., CHAI S., Tong M., Guan X., Lin C., Ching Y.P., Xie D., Cheng A.S. and Ma S.K.Y., C-terminal truncated hepatitis B virus X protein promotes hepatocellular carcinogenesis through induction of cancer and stem cell-like properties, Oncotarget. 2016.

Xu H.T., Lai W.L., Liu H.F., Wong L.L.Y., Ng I.O.L. and Ching Y.P., PAK4 phosphorylates p53 at serine 215 to promote liver cancer metastasis., Cancer Research. American Association for Cancer Research., 2016, 76: 5732-5742.

Xu Y.M., Gao Y.M., Wu D.D., Yu F.Y., Zang Z.S., Yang L., Yao Y., Cai N.L., Zhou Y., Chiu J.F., Ching Y.P. and Lau A.T., Aberrant cytokine secretion and zinc uptake in chronic cadmium-exposed lung epithelial cells, PROTEOMICS - Clinical Applications. 2017, 11: 1600059.

Researcher : Choi CG

List of Research Outputs

Wong S.L., Choi C.G. and Lu T.K., Deciphering combinatorial genetics, Annual Reviews of Genetics . 2016, 50: 515-538.

Researcher : Chu MT

Project Title:	Neuroscience 2016, Society for Neuroscience; Endurance training increases FGF21 expression and improves memory function in Alzheimer’s disease mice
Investigator(s):	Chu MT
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2016
Completion Date:	11/2016

List of Research Outputs

Chu M.T., Ho Y.S., Wong G.T.C. and Chang R.C.C., Aerobic training increased FGF21 expression and attenuated cognition in Alzheimer’s disease mice. , International Alzheimer’s Disease Conference 2017. 42.

HUANG C., LIU Y., Chu M.T., Chang R.C.C. and Wong G.T.C., The effect of varenicline on DNA damage and tau mislocalization in the cognitive impairment induced by laparotomy., International Alzheimer’s Disease Conference 2017. 39.

Researcher : Chung SK

Project Title:	Stem Cell Strategy for Nervous System Disorders
Investigator(s):	Chung SK
Department:	School of Biomedical Sciences
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	09/2012

Project Title:	Aldose Reductase(AR) effect dopaminergic neuronal autophagy through microglia after acute inflammation in Parkinson’s disease
Investigator(s):	Chung SK
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2015

Project Title:	To determine the role of Exchange Proteins Directly Activated by cAMP (Epac) in the gut microbiota-mediated metabolic syndrome
Investigator(s):	Chung SK
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2015

Project Title:	Molecular basis of beta3-adrenergic receptor agonists on anxiolytic-and anti-depressive action: cAMP/Epac2 as a potential signal to improve neuronal mitochondrial biogenesis and neurogenesis.
Investigator(s):	Chung SK
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

Project Title:	To determine the role of exchange protein directly activated by cAMP in the blood-retinal barrier and pathogenesis of diabetic retinopathy
Investigator(s):	Chung SK
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2016

Project Title:	Interaction between activated aldose reductase, non-enzymatic glycation, PKC and hexosamine pathways for the pathogenesis of diabetic complications
Investigator(s):	Chung SK
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2016

Project Title:	Cellular Mechanisms of Synaptic Functions and Plasticity in Health and Neurodegenerative Diseases
Investigator(s):	Chung SK
Department:	School of Biomedical Sciences
Source(s) of Funding:	Areas of Excellence Scheme
Start Date:	06/2017

List of Research Outputs

Baretella O.M., Chung S.K., Xu A. and Vanhoutte P.M.G.R., Endothelial overexpression of endothelin-1 modulates aortic, carotid, iliac and renal arterial responses in obese mice, Acta Pharmacologica Sinica. 2017, 38: 498-512.

CHAN K.C., ZHOU Y., LIU S.S., van der Merwe Y., FAN S., HUNG K., Chung S.K., Wu W., So K.F. and Wu E.X., Longitudinal Assessments of Normal and Perilesional Tissues in Focal Brain Ischemia and Partial Optic Nerve Injury with Manganese-enhanced MRI, Scientific Reports. 2017, 7: 43124.

FENG R., TIRRELL L., Cheung C.W. and Chung S.K., Deleted in Liver Cancer 2-deficiency Lead to more Severe Inflammatory Pain in Diabetic Mice with Altered Nerve Morphology and Activated RhoA/pERK/NF7, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

GAO C., Wang Q., Chung S.K. and Shen J., Crosstalk of metabolic factors and neurogenic signaling in adult neurogenesis: Implication of metabolic regulation for mental and neurological diseases., Neurochemistry International . 2017, 2017:106: 24-36.

LI L., Yeung P.K.K. and Chung S.K., Dopamine Transporter (DAT)-expressing Cells Specific CR6-interacting Factor 1 (DATCrif1) Knockout Mice as an Experimental Animal Model for Study the Pathogenesis and Discovery of Novel Treatment of Parkinson’s Disease, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

LIAO B., GENG L., Chung S.K., Lam K.S.L., Xu A. and Hoo R.L.C., Inhibition of A-FABP attenuated cerebral ischemia injury via alleviating MMP-9-mediated blood-brain barrier disruption, The 99th Annual Meeting of the American Endocrine Society, 1-4 April 2017, Orlando, USA. 2017.

Lu J., Yao X., LUO X., Wang Y., Chung S.K., Tang H., Cheung C.W., Wang X., Meng C. and Li Q., Monosialoganglioside 1 may alleviate neurotoxicity induced by propofol combined with remifentanil in neural stem cells, Neural Regeneration Research. 2017, 12: 945.

Ng C.L., Cheng O.Y., JIAN M., Kwan S.C., Ho W.L., Cheng K.Y., Yeung P.K.K., Zhou L., Hoo R.L.C., Chung S.K., Xu A., Lam K.S.L. and Chan K.H., Chronic adiponectin deficiency leads to Alzheimer’s disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice, Molecular Neurodegeneration. 2016, 11: 71-87.

Sango K., Niimi N., Yako H., Tsukamoto M., Mizukami H. and Chung S.K., Establishment of a spontaneously immortalized Schwann cell line IKARS1 from aldose reductase-deficient mice, Neuroscience 2016.

TAM S.W., Lau K.W.W., Yeung P.K.K., Law A.C.K. and Chung S.K., Endothelin-1 induced cofilin rod formation in hippocampal neurons via endothelin type B receptor and NADPH oxidase-mediated oxidative stress pathway, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Tian G., LUO X., Tang C., Cheng X., Chung S.K., Xia Z., Cheung C.W. and Guo Q., Astrocyte contributes to pain development via MMP2-JNK1/2 signaling in a mouse model of complex regional pain syndrome, Life Sciences. 2017, 170: 64-71.

XU W., Li B., Guan X., Chung S.K., Yang W., Yip Y.L., Law S.Y.K., Chan K.T., Lee N.P.Y., Chan K.W., Xu L.Y., Li E.M., Tsao G.S.W., He Q.Y. and Cheung A., Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression, Nature Communications. 2017, 8: 14399.

Yeung P.K.K., Lai A.K.W., Son H.J., Zhang X., Hwang O., Chung S.S.M. and Chung S.K., Aldose reductase deficiency leads to oxidative stress-induced dopaminergic neuronal loss and autophagic abnormality in an animal model of Parkinson's disease, Neurobiology of Aging. 2017, 50: 119-133.

Zhou L., Ma S.L., Yeung P.K.K., Wong Y.H., Tsim K.W.K., Lam L.C.W. and Chung S.K., Anxiety and depression with neurogenesis defects in exchange protein directly activated by cAMP 2-deficient mice are ameliorated by a selective serotonin reuptake inhibitor, Prozac, Translational Psychiatry. 2016.

Researcher : Chung WH

List of Research Outputs

Cheng W.H., Chung W.H. and NG J.C.F., Structural Dynamics of Amyloid-β Aggregation in Alzheimer’s Disease: Computational and Experimental Approaches, Journal of Young Investigators. 2016.

Researcher : Chung WSE

List of Research Outputs

Chan L.K., Chen J.Y. and Chung W.S.E., Hong Kong Publishing Biennial Awards 2017, "Publishing Award” in the category of "Life and Science”, for the book “Dissecting the Meaning of Life – An Anthology of Essays on Body Donation” (大體大得——遺體捐贈感思文集), Hong Kong Publishing Professionals’s Society. 2017.

Researcher : DENG J

List of Research Outputs

Deng J. and Jin D., 2016 International HBV Meeting Travel Award, 2016 International HBV Meeting. 2016.

Deng J., Kong K.Y., Gao W., Tang H.M.V., CHAUDHARY V., CHENG Y., Zhou J., Chan C.P., Wong D.K.H., Yuen R.M.F. and Jin D., Interplay between SIRT1 and hepatitis B virus X protein in the activation of viral transcription, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 2017, 1860: 491-501.

Deng J., Kong K.Y., GAO W., Tang H.M.V., Chan C.P. and Jin D., Sirtuins are potent activators of hepatitis B virus transcription., 2016 International HBV Meeting.. Seoul, Korea, 2016.

Jin D., GAO W., Deng J., Kong K.Y. and Chan C.P., Suppression of hepatitis B virus transcription by LKB1 tumor suppressor and salt-inducible kinases, 2016 International HBV Meeting. Seoul, Korea, 2016.

Kong K.Y., Deng J., GAO W., Tang H.M.V., CHAUDHARY V., CHENG Y., Wong D.K.H., Yuen R.M.F., Ma S.K.Y., Chan C.P. and Jin D., PRMT5 protein arginine methyltransferase activates hepatitis B virus transcription., 2016 International HBV Meeting.. Seoul, Korea, 2016.

XU C., LIN Q., DENG J., Yu B., ARYA S. and Huang J., Live attenuated Salmonella-based Vaccines delivering SaEsxA by Type III Secretion System Confer Protection against Staphylococcus aureus Infection, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : DIRKZWAGER RM

List of Research Outputs

Cheung Y.W., SHIU C.C., FRASER L.A., LIANG S., Dirkzwager R.M., Kinghorn A.B., TANG S.L.M. and Tanner J.A., Aptamer-mediated biosensing: from malaria diagnosis to DNA nanostructure dynamics, 5th International Conference on Bio-Sensing Technology. 2017.

Cheung Y.W., DIRKZWAGER R.M., FRASER L.A., Richards J.S. and Tanner J.A., DNA aptamer targeting Plasmodium falciparum histidine rich protein 2: Development of aptamer—antibody sandwich assay for malaria rapid diagnosis, International Congress for Tropical Medicine and Malaria. 2016.

Cheung Y.W., SHIU C.C., Wong W.C., TANG S.L.M., DIRKZWAGER R.M., LIANG S., KINGHORN A.B., FRASER L.A. and Tanner J.A., From DNA aptamer structure to splitting for use in DNA nanotweezers, Oligo 2017 Oxford: Antisense & Therapeutic Nucleic Acids. 2017.

FRASER L.A., Kinghorn A.B., Dirkzwager R.M., Cheung Y.W., Richards J. and Tanner J.A., 3D Printed Microfluidics for Point of Care Malaria Diagnosis, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

KINGHORN A.B., DIRKZWAGER R.M., LIANG S., Cheung Y.W., FRASER L.A., SHIU C.C., TANG S.L.M. and Tanner J.A., Aptamer Affinity Maturation by Resampling and Microarray Selection, Analytical Chemistry. American Chemical Society, 2016, 88: 6981-6985.

Miranda G.F., Feng L., SHIU C.C., DIRKZWAGER R.M., Tanner J.A., Schöning M.J., Offenhäusser A. and Mayer D., Aptamer-based electrochemical biosensor for highly sensitive and selective malaria detection, 1st International Symposium for Biomedical Research. 2017.

SHIU C.C., Cheung Y.W., DIRKZWAGER R.M., LIANG S., Kinghorn A.B., FRASER L.A., TANG S.L.M. and Tanner J.A., A split aptamer can facilitate protein recognition in DNA nanotweezers, Aptamers 2017, 4th Oxford Symposium on Aptamers. 2017.

SHIU C.C., Cheung Y.W., DIRKZWAGER R.M., LIANG S., Kinghorn A.B., FRASER L.A., TANG S.L.M. and Tanner J.A., Aptamer-Mediated Protein Molecular Recognition Driving a DNA Tweezer Nanomachine, Advanced Biosystems. 2017, 1: 1600006.

SHIU C.C., Cheung Y.W., Dirkzwager R.M., LIANG S., Kinghorn A.B., FRASER L.A., Tang S.L.M. and Tanner J.A., DNA Tweezer Nanomachine Mediated by Heterogeneous Recognition, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

SHIU C.C., TANG S.L.M., DIRKZWAGER R.M., LIANG S., Kinghorn A.B., Cheung Y.W., FRASER L.A., Godonoga M., Heddle J.G. and Tanner J.A., Protein driven aptamer toehold switches integrated into DNA origami nanostructures, Oligo 2017 Oxford: Antisense & Therapeutic Nucleic Acids. 2017.

Wang W.X., Cheung Y.W., DIRKZWAGER R.M., Wong W.C., Tanner J.A., Li H.W. and Wu Y., Specific and sensitive detection of Plasmodium falciparum lactate dehydrogenase by DNA-scaffolded silver nanoclusters combined with an aptamer, The Analyst. 2017, 142: 800-807.

Researcher : DONG R

List of Research Outputs

DONG R., Tong C.K.B. and Cheung K.H., Impaired Ca2+ Homeostasis in Lysosome Caused by FAD-linked Presenilin-1 Mutation is Responsible for Autophagy Defection in Familial Alzheimer’s Disease, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

DONG R., TONG C.K.B. and Cheung K.H., Lysosomal Ca2+ disruption induces autophagy impairment in familial Alzheimer’s disease, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : DU Y

List of Research Outputs

YAN L., Xie S., DU Y. and Qian C., Structural Insights into BAF47 and BAF155 Complex Formation, Journal of Molecular Biology. 2017, 429: 1650-1660.

YAN L., Xie S., DU Y. and Qian C., Structural and Biochemical Study of Core Regulatory Machinery of BAF Chromatin Remodeling Complex, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

YAN L., Xie S., DU Y. and Qian C., Structural insights into BAF47 and BAF155 complex formation, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : DUAN Z

List of Research Outputs

DUAN Z., Kinesin-1 regulates extrasynaptic NMDAR targeting and its reduction can confer neuroprotection (PhD thesis), The University of Hong Kong. 2017.

He S., Xue W., DUAN Z., Sun Q., Li X., Gan H., Huang J. and Qu J., Multimodal Nonlinear Optical Microscopy Reveals Critical Role of Kinesin-1 in Cartilage Development, Biomedical Optics Express. 2017, 8(3): 1771-1782.

Researcher : Deng J

Project Title:	2016 Transcriptional Regulation Chromatin and RNA Polymerase II Special Symposium; Transcription of Hepatitis B virus is activated by PRMT5 protein arginine methyltransferase, a potential antiviral target
Investigator(s):	Deng J
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/2016
Completion Date:	10/2016

List of Research Outputs

Deng J. and Jin D., 2016 International HBV Meeting Travel Award, 2016 International HBV Meeting. 2016.

Deng J., Kong K.Y., GAO W., Tang H.M.V., Chan C.P. and Jin D., Sirtuins are potent activators of hepatitis B virus transcription., 2016 International HBV Meeting.. Seoul, Korea, 2016.

Researcher : Deng W

Project Title:	Role of Bmi-1 in the persistence of Epstein-Barr virus (EBV) in nasopharyngeal epithelial cells
Investigator(s):	Deng W, Tsao GSW, Huen MSY, Tsang CM
Department:	Anatomy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	01/2013
Completion Date:	08/2016

Project Title:	A novel function of IL-6/IL-6R?signaling activation in nasopharyngeal epithelial cells: facilitation of cellular immortalization
Investigator(s):	Deng W, Tsao GSW, Chen H
Department:	School of Nursing
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	Immortalization of human uterine cervical epithelial cells without viral oncogene expression
Investigator(s):	Deng W, Tsao GSW
Department:	School of Nursing
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2015
Completion Date:	02/2017

Project Title:	Role of IL-6/IL-6Rα signaling activation in supporting persistent EBV infection in premalignant nasopharyngeal epithelial cells
Investigator(s):	Deng W, Tsao GSW
Department:	School of Nursing
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2017

List of Research Outputs

Jia L.J., Tsang C.M., Yip Y.L., Law W.T., ZHANG J., Deng W. and Tsao G.S.W., Establishment and characterization of immortalized nasopharyngeal epithelial cells with stable infection of Epstein-Barr virus, AMPK 2016: New Mechanism and Physiology. 2016.

ZHANG J., Jia L.J., Lin W., Yip Y.L., LAU V.M.-.Y., Zhu D., Tsang C.M., Zhou Y.L., Deng W., Lung H.L., Lung M.L., Cheung A. and Tsao G.S.W., Epstein-Barr Virus Encoded Latent Membrane Protein-1 Induces Glucose Transporter-1 Transcription is Dependent on the mTORC1 Mediated NF-κB Pathway Activation, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

ZHANG J., Jia L.J., Lin W., Yip Y.L., Lo K.W., LAU V.M.-.Y., Zhu D., Tsang C.M., Zhou Y., Deng W., Lung H.L., Lung M.L., Cheung L.M. and Tsao G.S.W., Epstein-barr Virus-encoded Latent Membrane Protein 1 Upregulates Glucose Transporter 1 Transcription Via The Mtorc1/nf-κb Signaling Pathways, Journal of Virology. 2017, 91: e02168-16.

Researcher : Dirkzwager RM

List of Research Outputs

Researcher : Dung WF

List of Research Outputs

YU Z., TANG L.F., WANG J., Bao S., SHIEH J.T., LEUNG A.W.L., Gao F., ZHANG Z., WONG S.Y.Y., HUI A.L.C., Dung W.F., ZHANG Z., Fan Y., Wong S.M., Sham P.C., AZHAR A., KWOK P.Y., TAM P.P.L., Lian Q. and Cheah K.S.E., Hnrnpa1 Mutations Cause Congenital Heart Defects, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : FAN W

List of Research Outputs

FAN W., Toward exploring cellular metastated through light-induced tuning of Oct4 expression (PhD Thesis), The University of Hong Kong. 2017.

Researcher : FENG R

List of Research Outputs

FENG R., TIRRELL L., Cheung C.W. and Chung S.K., Deleted in Liver Cancer 2-deficiency Lead to more Severe Inflammatory Pain in Diabetic Mice with Altered Nerve Morphology and Activated RhoA/pERK/NF7, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

Researcher : FENG Y

List of Research Outputs

FENG Y., Regulation of Circadian rhythms by Sirtuin 6 (MPhil Thesis), The University of Hong Kong. 2016.

Researcher : FENG Z

List of Research Outputs

FENG Z., Yu B. and Huang J., RNAi-effecting vector construction in “obligate” anaerobic Salmonella strain YB1 as a potentially competent payload in cancer treatment, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : FRASER LA

List of Research Outputs

Cheung Y.W., SHIU C.C., FRASER L.A., LIANG S., Dirkzwager R.M., Kinghorn A.B., TANG S.L.M. and Tanner J.A., Aptamer-mediated biosensing: from malaria diagnosis to DNA nanostructure dynamics, 5th International Conference on Bio-Sensing Technology. 2017.

Cheung Y.W., DIRKZWAGER R.M., FRASER L.A., Richards J.S. and Tanner J.A., DNA aptamer targeting Plasmodium falciparum histidine rich protein 2: Development of aptamer—antibody sandwich assay for malaria rapid diagnosis, International Congress for Tropical Medicine and Malaria. 2016.

Cheung Y.W., SHIU C.C., Wong W.C., TANG S.L.M., DIRKZWAGER R.M., LIANG S., KINGHORN A.B., FRASER L.A. and Tanner J.A., From DNA aptamer structure to splitting for use in DNA nanotweezers, Oligo 2017 Oxford: Antisense & Therapeutic Nucleic Acids. 2017.

FRASER L.A., Kinghorn A.B., Dirkzwager R.M., Cheung Y.W., Richards J. and Tanner J.A., 3D Printed Microfluidics for Point of Care Malaria Diagnosis, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

KINGHORN A.B., DIRKZWAGER R.M., LIANG S., Cheung Y.W., FRASER L.A., SHIU C.C., TANG S.L.M. and Tanner J.A., Aptamer Affinity Maturation by Resampling and Microarray Selection, Analytical Chemistry. American Chemical Society, 2016, 88: 6981-6985.

SHIU C.C., Cheung Y.W., DIRKZWAGER R.M., LIANG S., Kinghorn A.B., FRASER L.A., TANG S.L.M. and Tanner J.A., A split aptamer can facilitate protein recognition in DNA nanotweezers, Aptamers 2017, 4th Oxford Symposium on Aptamers. 2017.

SHIU C.C., Cheung Y.W., DIRKZWAGER R.M., LIANG S., Kinghorn A.B., FRASER L.A., TANG S.L.M. and Tanner J.A., Aptamer-Mediated Protein Molecular Recognition Driving a DNA Tweezer Nanomachine, Advanced Biosystems. 2017, 1: 1600006.

SHIU C.C., Cheung Y.W., Dirkzwager R.M., LIANG S., Kinghorn A.B., FRASER L.A., Tang S.L.M. and Tanner J.A., DNA Tweezer Nanomachine Mediated by Heterogeneous Recognition, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

SHIU C.C., TANG S.L.M., DIRKZWAGER R.M., LIANG S., Kinghorn A.B., Cheung Y.W., FRASER L.A., Godonoga M., Heddle J.G. and Tanner J.A., Protein driven aptamer toehold switches integrated into DNA origami nanostructures, Oligo 2017 Oxford: Antisense & Therapeutic Nucleic Acids. 2017.

Researcher : FUNG CW

List of Research Outputs

FUNG C.W., Chan W. and Yao K.M., Partnering role of FOXM1 and EPS8 in maintaining chemoresistance in human ovarian cancer, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : FUNG SW

List of Research Outputs

FUNG S.W., Cheung P.F.Y., Yip C.W., NG W.C., Cheung T.T., CHONG C.C.N., Tsao G.S.W. and CHEUNG S.T., Expression of ATP-binding cassette transporter ABCF1 in fetal liver and liver cancer associated with cancer stem cell markers and chemo-resistance, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : FUNG SY

List of Research Outputs

Chan C.P., Yuen C.K.J., Fung S.Y., CHEUNG P.H.H., Chen H., Kok K.H. and Jin D., Antiviral activity of double-stranded RNA-binding protein PACT against influenza A virus mediated through suppression of viral RNA polymerase, FOCIS 2017.

FUNG S.Y., YUEN C.K., ZHU W., LIANG G., Kok K.H., Chan C.P. and Jin D., Activation of nucleic acid sensing cGAS-STING pathway by Sindbis Virus, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

FUNG S.Y., Chan C.P., YUEN C.K., Kok K.H., Chan C.P. and Jin D., Human T-cell leukemia virus type 1 Tax and HBZ proteins differentially suppress RNA- and DNA-induced innate antiviral response., 18th International Conference on Human Retrovirology: HTLV-1 and Related Viruses, Tokyo, Japan, March 7-10, 2017.. 2017.

Wang F., FUNG S.Y., Chan C.P. and Jin D., Induction by HTLV-1 of a transcript isoform of STING that suppresses innate antiviral response., 18th International Conference on Human Retrovirology: HTLV-1 and Related Viruses, Tokyo, Japan, March 7-10, 2017.. 2017.

Researcher : Fan Y

List of Research Outputs

Chen L.P., Fan Y., Kao P.Y., Ho D.T., Ha C.T.J., Chu L.W. and Song Y., Genetic Polymorphisms in Estrogen Metabolic Pathway Associated with Risks of Alzheimer's Disease: Evidence from a Southern Chinese Population, J Am Geriatr Soc.. 2017, 65(2): 332-339.

Fan Y. and Song Y., PyHLA: tests for the association between HLA alleles and diseases, BMC Bioinformatics. 2017, 18(1): 90.

YU Z., TANG L.F., WANG J., Bao S., SHIEH J.T., LEUNG A.W.L., Gao F., ZHANG Z., WONG S.Y.Y., HUI A.L.C., Dung W.F., ZHANG Z., Fan Y., Wong S.M., Sham P.C., AZHAR A., KWOK P.Y., TAM P.P.L., Lian Q. and Cheah K.S.E., Hnrnpa1 Mutations Cause Congenital Heart Defects, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : Fu C

Project Title:	Systematic investigation of the roles of mitotic kinesins in spindle dynamics
Investigator(s):	Fu C
Department:	School of Biomedical Sciences
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2013

Project Title:	Molecular mechanisms of nuclear congression
Investigator(s):	Fu C
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016

List of Research Outputs

LI T., Zheng F., Cheung M.C.H., WANG F. and Fu C., Fission yeast mitochondria are distributed by dynamic microtubules in a motor-independent manner, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : Fung ML

Project Title:	Pathophysiological role of nitric oxide deficit in the carotid body function in intermittent hypoxia
Investigator(s):	Fung ML
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2015
Completion Date:	02/2017

Project Title:	Pathophysiological role of local inflammation in nitric oxide deficit in the carotid body in intermittent hypoxia
Investigator(s):	Fung ML
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2016

Project Title:	Pathophysiological roles of monoamine oxidase A in the oxidative stress and hippocampal neurodegeneration induced by chronic intermittent hypoxia
Investigator(s):	Fung ML
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

List of Research Outputs

Fung M.L., Roles of the adrenal gland in the pathophysiological consequences of sleep apnea. The 33^rd Annual Scientific Meeting of Hong Kong Society of Endocrinology, Metabolism and Reproduction, Hong Kong. 2016.

Guo R., Lin B., PAN J., Liong E.C., Xu A., Youdim M., Fung M.L., So K.F. and Tipoe G.L., Inhibition of caspase-9 aggravates acute liver injury through suppression of cytoprotective autophage, Scientific Reports. 2016, 6: 32447.

Hung M.W., Yeung H.M., Lau C.F., Poon A.M.S., Tipoe G.L. and Fung M.L., Melatonin attenuates pulmonary hypertension in chronically hypoxic rats, International Journal of Molecular Sciences. 2017, 18(6): 1125.

Kang J.J., Liang W.H., Lam C.S., Huang X.F., Yang S.J., Wong-Riley M.T., Fung M.L. and Liu Y.Y., Catecholaminergic neurons in synaptic connections with pre-Botzinger complex neurons in the rostral ventrolateral medulla in normoxic and daily acute intermittent hypoxic rats, Experimental Neurology. 2017, 287: 165-175.

LAM C.S., Tipoe G.L., Wong K.C., Youdim M.B.H. and Fung M.L., M30 Antagonizes Indoleamine 2,3-Dioxygenase Activation and Neurodegeneration Induced by Corticosterone in the Hippocampus, In: Kenji Hashimoto, Chiba Daigaku, PLoS ONE. 2016.

Lam C.S., LI J., Tipoe G.L., Youdim M.B.H. and Fung M.L., Monoamine oxidase A upregulated by chronic intermittent hypoxia activates indoleamine 2,3-dioxygenase and neurodegeneration, PLoS One . 2017, 12(6): e0177940.

Lam C.S., Tipoe G.L., Wong J.K.C. and Fung M.L., Neuroprotective effect of multifunctional drug M30 against depressive-like behavior induced by hypercortisolemia in rats. The 30^th World Congress of the International College of Neuropsychopharmacology. Seoul, International Journal of Neuropsychopharmacology. 2016, 19, Issue Suppl. (1): 47-48.

Lau O.C., Shen C.O., Tjong Y.W., Lo C.Y., Wang H.C., Huang Y., Yung W.H., Chen Y.C., Fung M.L., Rudd J.A. and Yao X., TRPC5 channels participate in pressure-sensing in aortic baroreceptors, Nature Communications. 2016, 7: 11947.

Researcher : Fung SY

List of Research Outputs

Researcher : Fung TM

List of Research Outputs

Fung T.M., Ng K.Y., Tong M., CHEN J., Chai S., Chan K.T., Law S.Y.K., Lee N.P.Y., Choi M.Y., Li B., Cheung A., Tsao G.S.W., Qin Y.R., Guan X., Chan K.W. and Ma S.K.Y., Neuropilin-2 promotes tumourigenicity and metastasis in oesophageal squamous cell carcinoma through ERK-MAPK-ETV4-MMP-E-cadherin deregulation, Journal of Pathology. 2016, 239(3): 309-319.

Researcher : GAO W

List of Research Outputs

CHENG Y., GAO W., Tang H.M.V. and Jin D., β-TrCP targets liver-enriched and membrane-bound transcription factor CREB-H for ubiquitination and degradation., 16th International Union of Biochemistry and Molecular Biology (IUBMB) Conference: Signaling Pathways in Development, Diseases and Aging.. Vancouver, Canada, 2016.

Deng J., Kong K.Y., Gao W., Tang H.M.V., CHAUDHARY V., CHENG Y., Zhou J., Chan C.P., Wong D.K.H., Yuen R.M.F. and Jin D., Interplay between SIRT1 and hepatitis B virus X protein in the activation of viral transcription, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 2017, 1860: 491-501.

Deng J., Kong K.Y., GAO W., Tang H.M.V., Chan C.P. and Jin D., Sirtuins are potent activators of hepatitis B virus transcription., 2016 International HBV Meeting.. Seoul, Korea, 2016.

GAO W., Regulation of ubiquitination and degradation of CRTC1 transcriptional coactivator by salt-inducible kinase SIK1 (PhD Thesis), The University of Hong Kong. 2016.

GAO W., Tang H.M.V., CHENG Y., WANG P. and Jin D., Regulation of ubiquitination and degradation of CRTC1 transcriptional coactivator by salt-inducible kinase SIK1., 16th International Union of Biochemistry and Molecular Biology (IUBMB) Conference: Signaling Pathways in Development, Diseases and Aging.. Vancouver, Canada, 2016.

Jin D., GAO W., Deng J., Kong K.Y. and Chan C.P., Suppression of hepatitis B virus transcription by LKB1 tumor suppressor and salt-inducible kinases, 2016 International HBV Meeting. Seoul, Korea, 2016.

Kong K.Y., Deng J., GAO W., Tang H.M.V., CHAUDHARY V., CHENG Y., Wong D.K.H., Yuen R.M.F., Ma S.K.Y., Chan C.P. and Jin D., PRMT5 protein arginine methyltransferase activates hepatitis B virus transcription., 2016 International HBV Meeting.. Seoul, Korea, 2016.

Researcher : GHOSH S

List of Research Outputs

IEONG I.L., GHOSH S. and Zhou Z., Characterization of KAP1 acetylation and its roles in DNA damage repair, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : GUO R

List of Research Outputs

GUO R., Autophagy mediated by caspase-9 and cathepsin B plays a cytoprotective role in acute liver injury and nonalcoholic steatohepatitis, PhD Thesis, The University of Hong Kong. 2016.

Guo R., Lin B., PAN J., Liong E.C., Xu A., Youdim M., Fung M.L., So K.F. and Tipoe G.L., Inhibition of caspase-9 aggravates acute liver injury through suppression of cytoprotective autophage, Scientific Reports. 2016, 6: 32447.

Researcher : GUO Y

List of Research Outputs

GUO Y., A Study of Protein Phosphorylation and Ubiquitination in DNA Double Strand Break Responses (PhD Thesis), The University of Hong Kong. 2016.

GUO Y., AN L., NG H.M., Sy M.H. and Huen M.S.Y., An E2-guided E3 Screen Identifies the RNF17-UBE2U Pair as Regulator of the Radiosensitivity, Immunodeficiency, Dysmorphic Features, and Learning Difficulties (RIDDLE) Syndrome Protein RNF168., Journal Of Biological Chemistry. 2017, 292: 967-978.

Researcher : Gao B

Project Title:	Characterize the in vivo functional significance of Vangl2 phosphorylation in Planar Cell Polarity (PCP)
Investigator(s):	Gao B
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2015

Project Title:	Identifying the genetic variants underlying carpal tunnel syndrome in a big family
Investigator(s):	Gao B, Song Y
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2016

Project Title:	Gordon Research Conference: Musculoskeletal Biology & Bioengineering; Mutation in an extracellular matrix protein causes carpal tunnel syndrome (Global Directional Cues in Establishing Planar Cell Polarity During Long Bone Development)
Investigator(s):	Gao B
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2016
Completion Date:	08/2016

Project Title:	Genetic Studies of Congenital Scoliosis
Investigator(s):	Gao B, Cheung JPY, Song Y
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2017

List of Research Outputs

Gao B., Global Directional Cues in Establishing Planar Cell Polarity During Skeletal Morphogenesis, Gordon Research Conference: Musculoskeletal Biology & Bioengineering. 2016.

Gao B., Global directional cues in establishing planar cell polarity during skeletal morphogenesis, Cold Spring Harbor Meeting-Asia: Bone & Cartilage: From development to human diseases. 2016.

Gao B., Lack of Casein Kinase 1 Delta Promotes Genomic Instability-The Accumulation of DNA Damage and Down-Regulation of Checkpoint Kinase 1, PLoS one. PLOS, 2017, 12.

Gao B., Non-Canonical Wnt/Planar Cell Polarity Signaling in Early Skeletal Morphogenesis, The 11th International Congress on Orthopaedic Advanced Techniques and Clinical Translation Research. 2017.

Gao B., Wnt Regulation of Planar Cell Polarity, City University of Hong Kong. 2016.

Gao B., Wnt Regulation of Planar Cell Polarity, The 4th International Anatomical Sciences and Cell Biology Conference. 2016.

Gao B., Wnt/Planar Cell Polarity Signaling in Skeletal Morphogenesis and Skeletal Disease, The 2nd National Conference of Chinese Society of Matrix Biology. 2017.

Researcher : Gao W

List of Research Outputs

Deng J., Kong K.Y., GAO W., Tang H.M.V., Chan C.P. and Jin D., Sirtuins are potent activators of hepatitis B virus transcription., 2016 International HBV Meeting.. Seoul, Korea, 2016.

GAO W., Regulation of ubiquitination and degradation of CRTC1 transcriptional coactivator by salt-inducible kinase SIK1 (PhD Thesis), The University of Hong Kong. 2016.

Researcher : Guo R

List of Research Outputs

GUO R., Autophagy mediated by caspase-9 and cathepsin B plays a cytoprotective role in acute liver injury and nonalcoholic steatohepatitis, PhD Thesis, The University of Hong Kong. 2016.

Researcher : HAU WF

List of Research Outputs

HAU W.F., Variation of chondritin sulfation as a mechanism of turning neuroplasticity during development and vestibular compensation (MPhil Thesis), The University of Hong Kong. 2017.

Hau W.F., Chan Y.S. and Shum D.K.Y., Sulfation patterns of chondroitins in the rat brainstem during development and vestibular compensation, Abstracts of 10^th FENS Forum of Neuroscience, 1771. [Copenhagen, Denmark. July 2-6, 2016]. 2016.

Researcher : HO CC

List of Research Outputs

Chan L.K., Wong F.K.Y., Ganotice F.J.A., Lau W.C.S., Lam T.P., Bridges S.M., Chan N.K., Chan W.L.P., Chen H., Chen J.Y., Chu K.P.J., Ho C.C., Ho J.M.C., Chin W.Y., Harbutt D., Khoo U.S., Lam S.F., Lao L., Leung G.K.K. and Li Q., Bronze in Discipline Award (Life Sciences), in Quacquarelli Symonds (QS) Reimagine Education competition: Interprofessional Team-Based Learning for Health Professional Students, Quacquarelli Symonds. 2016.

HO C.C., QIN T., Wang B., Wong Y.M.E., LIU Y., Hui C.C. and Sham M.H., Sufu controls the proliferation and differentiation of cochlear prosensory progenitors, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

HO C.C., QIN T., Wang B., Wong Y.M.E., LIU Y., Hui C.C. and Sham M.H., Sufu regulates the proliferation and differentiation of hair cell progenitors in mammalian cochlea, 18th International Congress of Developmental Biology. 2017.

LIU Y., Wang B., Wong Y.M.E., Tsang S.L., HO C.C., Hui C.C. and Sham M.H., The roles of Irx3 and Irx5 in inner ear neurosensory patterning, 18th International Congress of Developmental Biology. 2017.

LIU Y., Wang B., Wong Y.M.E., Tsang S.L., HO C.C., Hui C.C. and Sham M.H., The roles of Irx3 and Irx5 in inner ear neurosensory patterning, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : HU M

List of Research Outputs

HU M., Guo J., Cheng Q., Yang Z., Chan E.W.C., Chen S. and Hao Q., Crystal Structure of Escherichia coli originated MCR-1, a phosphoethanolamine transferase for Colistin Resistance, Scientific Reports. 2016, 6: 38793.

HU M., Zhang H., Liu Q. and Hao Q., Structural Basis for Human PECAM-1-Mediated Trans-homophilic Cell Adhesion, Scientific Reports. 2016, 6: 38655.

HU M., Structural Studies on Human PECAM-1 Trans-homophilic Dimerization Revealing Cell Adhesion Mechanism (PhD Thesis), The University of Hong Kong. 2017.

Researcher : HUA Y

List of Research Outputs

HUA Y., A study of a virus-like particle vaccine against Aspergillus fumigatus, PhD Thesis, The University of Hong Kong. 2016.

ZHANG B., Cai J., Yu B., HUA Y., Lau C.Y., Kao R.Y.T., Sze K.H., Yuen K.Y. and Huang J., A DNA vaccine targeting TcdA and TcdB induces protective immunity against Clostridium difficile, BMC Infectious Diseases. 2016, 16.

Researcher : HUANG Y

List of Research Outputs

HUANG Y. and Lai S.W.C., Altered Synaptic Plasticity in a Mouse Schizophrenia Model, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

Researcher : HUNG CH

List of Research Outputs

HUNG C.H., Alternative of Intracellular Calcium Channel Expression Plays a Role in Asthma Pathogenesis in Mouse and Human, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

Researcher : HUNG TN

List of Research Outputs

HUNG T.N., Philip K H Wong Foundation Postgraduate Fellowship, Philip K H Wong Foundation. 2016.

Researcher : Han L

Project Title:	Postsynaptic plasticity: Differential roles of inhibitory and excitatory vestibular nuclear neurons
Investigator(s):	Han L, Chan YS
Department:	School of Biomedical Sciences
Source(s) of Funding:	Small Project Funding
Start Date:	01/2015

Project Title:	10th Federation of European Neuroscience Society Forum of Neuroscience; A comparative study of intrinsic membrane properties between inhibitory and excitatory neurons in medial vestibular nucleus
Investigator(s):	Han L
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2016
Completion Date:	07/2016

List of Research Outputs

Cai S., Han L., Ao Q., Chan Y.S. and Shum D.K.Y., Human induced pluripotent stem cell-derived sensory neurons for fate commitment of bone marrow-derived Schwann cells: Implications for re-myelination therapy, Stem Cells Translational Medicine. 2017, 6: 369-381.

Han L., Yanagawa Y. and Chan Y.S., A comparative study of intrinsic membrane properties between inhibitory and excitatory neurons in medial vestibular nucleus, Abstracts of 10^th FENS Forum of Neuroscience 277. [Copenhagen, Denmark. July 2-6, 2016]. 2016.

Han L. and Chan Y.S., Bidirectional action of 5-HT on synaptic transmission in rat medial vestibular nucleus, Frontiers in Cellular Neuroscience [14^th Meeting of Asian Pacific Society for Neurochemistry ]. 2016.

Han L., Young Investigator Award , Asian-Pacific Society for Neurochemistry . 2016.

Li Y.H., Han L., Wu L.K. and Chan Y.S., Activation of 5-HT₇ receptors reverses NMDA receptor-dependent LTD by activating PKA at medial vestibular neurons, Neuropharmacology. 2017, 123: 242-248.

Researcher : Hao Q

Project Title:	Investigation of pathogenesis mechanism of two infectious fungi Penicillium marneffei and Aspergillus fumigatus
Investigator(s):	Hao Q
Department:	School of Biomedical Sciences
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2014

Project Title:	Novel Structure and Function of Human Sirtuins
Investigator(s):	Hao Q, Huang J, Li XD
Department:	School of Biomedical Sciences
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	03/2015

Project Title:	Structural study of NDM-1: Towards rational inhibitor design against the antibiotic resistant “superbug”
Investigator(s):	Hao Q
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2016

Project Title:	Development of novel inhibitors targeting the resistance mechanisms of clinical superbugs
Investigator(s):	Hao Q
Department:	School of Biomedical Sciences
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2017

List of Research Outputs

CUI Y., Li X., LIN J., Hao Q. and Li X.D., Histone Ketoamide Adduction by 4-Oxo-2-nonenal Is a Reversible Posttranslational Modification Regulated by Sirt2, ACS Chemical Biology. 2017, 12: 47-51.

HU M., Guo J., Cheng Q., Yang Z., Chan E.W.C., Chen S. and Hao Q., Crystal Structure of Escherichia coli originated MCR-1, a phosphoethanolamine transferase for Colistin Resistance, Scientific Reports. 2016, 6: 38793.

HU M., Zhang H., Liu Q. and Hao Q., Structural Basis for Human PECAM-1-Mediated Trans-homophilic Cell Adhesion, Scientific Reports. 2016, 6: 38655.

Hao Q., Laue Serial Crystallography Using Synchrotron Radiation and X-FEL, The 14th Conference of the Asian Crystallographic Association, Hanoi, Vietnam, Dec 2016.. 2016.

Hao Q., Novel Structure and Function of Human Sirtuins, The 2nd Hubei Structural Biology Symposium, Wuhan, China. 2016.

PANG B., Cheung N.N., ZHANG W., Dai J., Kao R.Y.T., Zhang H. and Hao Q., Structural Characterization of H1N1 Nucleoprotein-Nucleozin Binding Sites, Scientific Reports. 2016, 6: 29684.

Sze K.H., Lam W.H., Zhang H., Ke Y., Tse M.K., Woo P.C.Y., Lau S.K.P., Lau C.Y., Cai J., Tung E.T., Lo R.K., Xu S., Kao R.Y.T., Hao Q. and Yuen K.Y., Talaromyces marneffei Mp1p Is a Virulence Factor that Binds and Sequesters a Key Proinflammatory Lipid to Dampen Host Innate Immune Response, Cell Chemical Biology. 2017, 24: 182-194.

Tong Z., Wang M., Wang Y., Kim D.D., Grenier J.K., Cao J., Sadhukhan S., Hao Q. and Lin H.N., SIRT7 Is an RNA-Activated Protein Lysine Deacylase, ACS Chemical Biology. 2016.

Wang Q., Guo W., Hao B., Shi X., Lu Y., Wong W.M., Ma V.W., Yip T.T., Au S.K., Hao Q., Cheung K.H., Wu W., Li G.R. and Yue J., Mechanistic study of TRPM2-Ca 2+ -CAMK2-BECN1 signaling in oxidative stress-induced autophagy inhibition , Autophagy. 2016, 12: 1340-1354.

Wang Y., Fung E.Y.M., ZHANG W., He B., CHUNG W.H., Jin J., Hu J., Lin H.N. and Hao Q., Deacylation Mechanism by SIRT2 Revealed in the 1′-SH-2′-O-Myristoyl Intermediate Structure, Cell Chemical Biology. 2017, 24: 339-345.

Woo P.C.Y., Lau S.K.P., Lau C.Y., Tung T.K., Chong T.K., Yang F., Zhang H., Lo K.C., Cai J., Au Yeung K.H.R., Ng W.F., Tse H., Wong S.S.Y., Xu S., Lam W.H., Tse M.K., Sze K.H., Kao R.Y.T., Reiner N.E., Hao Q. and Yuen K.Y., Mp1p Is a Virulence Factor in Talaromyces (Penicillium) marneffei, PLOS Neglected Tropical Diseases. 2016, 10: e0004907.

Xie Y., Ge J., Lei H., Peng B., Zhang H., Wang D., Pan S., Chen G., CHEN L., Wang Y., Hao Q., Yao S.Q. and Sun H.Y., Fluorescent Probes for Single-Step Detection and Proteomic Profiling of Histone Deacetylases, Journal of the American Chemical Society. 2016, 138: 15596-15604.

Researcher : Hau WF

List of Research Outputs

HAU W.F., Variation of chondritin sulfation as a mechanism of turning neuroplasticity during development and vestibular compensation (MPhil Thesis), The University of Hong Kong. 2017.

Researcher : Ho CC

List of Research Outputs

Researcher : Ho JWY

List of Research Outputs

Ho J.W.Y., Ngan W.L., Chan L.K., Cook S. and Bridges S.M., Assessments for Learning - A Double Edged-Sword? , Frontiers in Medical and Health Sciences Education. 2016.

Ho J.W.Y., Best Poster Presentation, BIMHSE, LKS Faculty Of Medicine, The University Of Hong Kong. 2016.

Ho J.W.Y. and Chan C.K.K., Knowledge Exchange Grant, The University Of Hong Kong. 2016.

YE L., Wong N.S. and Ho J.W.Y., Design,Development and Evaluation of Biochemistry Virtual Laboratory for Blended Learning, GSTF Journal of Education. 2016, 3: 40-45.

Researcher : Ho YS

List of Research Outputs

Chang R.C.C., YOU R., Hung H.L.C. and Ho Y.S., Environmental pollutants as risk factos for developing cognitive dysfunctions and Alzheimer’s disease. , The 10th Annual Scientific Meeting of Hong Kong Society of Biological Psychiatry: Brain and the Environment II. . 2017, 13.

Chu M.T., Ho Y.S., Wong G.T.C. and Chang R.C.C., Aerobic training increased FGF21 expression and attenuated cognition in Alzheimer’s disease mice. , International Alzheimer’s Disease Conference 2017. 42.

YOU R., Ho Y.S., Hung H.L.C. and Chang R.C.C., Evaluating the implication of silica nanoparticles in neurodegeneration, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

YOU R., Hung H.L.C., Ho Y.S. and Chang R.C.C., Investigating the effects of silica nanoparticles on neurodegeneratioive-like changes in behaviors and neuropathology. , International Alzheimer’s Disease Conference 2017. 40.

YOU R., Ho Y.S., Hung H.L.C., Lai S.W.C. and Chang R.C.C., Investigating the effects of slicia nanoparticles as affective and cognitive behaviors. , The 12th International Symposium on Healthy Aging. 2017, 50.

Yu S., Tang X., Ho Y.S., Chang R.C.C. and Chiu K., Links between the brain and retina: the effects of cigarette smoking-induced age-related changes in Alzheimer’s disease and macular degeneration., Frontiers in Neurology. 2016, 7: 119.

Researcher : Huang J

Project Title:	RNA-DNA hybrid oligonucleotide mediated site-specific repair and gene therapy
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Matching Fund for Hi-Tech Research and Development Program of China (863 Projects)
Start Date:	01/2003

Project Title:	Development of a Pan-organism Riboregulator Device
Investigator(s):	Huang J, Jin Y
Department:	School of Biomedical Sciences
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	11/2009

Project Title:	Development of a Pan-organism Riboregulator Device
Investigator(s):	Huang J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	12/2009

Project Title:	Outstanding Research Student Supervisor Award 2011-12
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Outstanding Research Student Supervisor Award
Start Date:	01/2013

Project Title:	Protein Trafficking: Mechanism and Diseases
Investigator(s):	Huang J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	04/2013

Project Title:	Non-canonical role of Kif5b in clathrin uncoating and the endocytic regulation of muscarinic acetylcholine receptors
Investigator(s):	Huang J, Ni Y
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2013

Project Title:	A Generic Mechanism for Pattern Formation: From Theoretical Physics To Synthetic Biology
Investigator(s):	Huang J
Department:	School of Biomedical Sciences
Source(s) of Funding:	France/Hong Kong Joint Research Scheme - Travel Grants
Start Date:	01/2014
Completion Date:	12/2016

Project Title:	Bridge the gap in nerve tissue injury to promote axonal regeneration with fabrication of a bioactive nanofibrous conduit
Investigator(s):	Huang J, Wu W
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2014

Project Title:	Pattern formation by bacteria: from theoretical physics to synthetic biology
Investigator(s):	Huang J
Department:	School of Biomedical Sciences
Source(s) of Funding:	ANR / RGC Joint Research Scheme
Start Date:	01/2015

Project Title:	A feasibility study on the inhibition of Staphylococcus aureus infection using AdsA specific antibodies
Investigator(s):	Huang J, Chen Z
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2015

Project Title:	Development of antibodies against Staphylococcus aureus infection
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Seed Fund for Translational and Applied Research
Start Date:	06/2015
Completion Date:	12/2016

Project Title:	Doris Zimmern HKU-Cambridge Hughes Hall Fellowships 2015-16
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Doris Zimmern HKU-Cambridge Hughes Hall Fellowships
Start Date:	09/2015

Project Title:	Characterization of the interaction between Kif5b and NMDAR in ischemic provoked neurodegeneration
Investigator(s):	Huang J, Sze KH
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016

Project Title:	Outstanding Researcher Award 2014-15
Investigator(s):	Huang J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	02/2016

Project Title:	Salmonella-induced host innate immunity against cancer metastasis
Investigator(s):	Huang J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

Project Title:	The International Conference on Vaccines Research & Development (Vaccines R&D-2016); A novel vaccine preventing Staphylococcus aureus infection
Investigator(s):	Huang J
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2016
Completion Date:	11/2016

Project Title:	Investigation of the interaction between kinesin heavy chain and kinesin light chain
Investigator(s):	Huang J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

Project Title:	Development of virus-like particle (VLP)-based vaccine against Streptococcus pneumoniae infection
Investigator(s):	Huang J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Translational and Applied Research
Start Date:	06/2017

List of Research Outputs

CHAN H.L., Huang J. and Lai K.O., The Kinesin Motor Protein KIF5B Regulates RNA Trafficking and Dendritic Spine Morphogenesis in Hippocampal Neuron, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

CHAN H.L., Huang J. and Lai K.O., To elucidate the role of the Kinesin motor protein KIF5B in mRNA transport and dendritic spine morphogenesis, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Cui J., Pang J., Lin Y.J., Gong H., Wang Z.H., Li Y.X., Li J., Wang Z., Jiang P., Dai D.P., Li J., Cai J.P., Huang J. and Zhang T.M., Adipose-specific Deletion of Kif5b Exacerbates Obesity and Insulin Resistance in a Mouse Model of Diet-induced Obesity, FASEB Journal. 2017, 31(6): 2533-2547.

Cui J., Pang J., Lin Y.J., Jiang P., Gong H., Wang Z., Li J., Cai J.P., Huang J. and Zhng T.M., Conventional kinesin KIF5B mediates adiponectin secretion in 3T3-L1 adipocytes, Biochemical and Biophysical Research Communications. 2016, 476: 620-626.

Durairajan S.S.K., Chirasani V.R., Shetty S.G., Iyaswamy A., Malampati S., Song J., Liu L., Huang J., Senapatib S. and Li M., Salvianolic acid B decreases the generation of amyloid-β by modulating BACE-1 activity, Current Alzheimer Research. 2017.

FENG Z., Yu B. and Huang J., RNAi-effecting vector construction in “obligate” anaerobic Salmonella strain YB1 as a potentially competent payload in cancer treatment, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

He S., Xue W., DUAN Z., Sun Q., Li X., Gan H., Huang J. and Qu J., Multimodal Nonlinear Optical Microscopy Reveals Critical Role of Kinesin-1 in Cartilage Development, Biomedical Optics Express. 2017, 8(3): 1771-1782.

Liu L., Huang W. and Huang J., Synthetic circuits that process multiple light and chemical signal inputs, BMC Systems Biology. 2017, 11(1): 5-14.

Lui N.C., Tam W.Y., Gao C., Huang J., Wang C.C., Jiang L., Yung W.H. and Kwan K.M., Lhx1/5 control dendritogenesis and spine morphogenesis of Purkinje cells via regulation of Espin, Nature Communications. 2017.

Ni Y., Cao B., Ma T., Niu G., Huo Y., Huang J., Chen D., Liu Y., Yu B. and Zhang M., Super-resolution imaging of a 2.5 kb non-repetitive DNA in situ in the nuclear genome using molecular beacon probes, eLife. 2017, 2050084X.

Ning B.T., Yu B., Chan S., Chan J.L., Huang J. and Chan G.C.F., Treatment of Neuroblastoma with an Engineered “Obligate” Anaerobic Salmonella typhimurium Strain YB1, Journal of Cancer. 2017, 8(9): 1609–1618.

Shi L., Yu B., Cai C.H. and Huang J., Angiogenic inhibitors delivered by the type III secretion system of tumor-targeting Salmonella typhimurium safely shrink tumors in mice, AMB Express. 2016, 6.

Su S., Liao J., Liu J., Huang D., He C., Chen F., Yang L.B., Wu W., Chen J., Lin L., Zeng Y., Ouyang N., Cui X., Yao H., Su F., Huang J., Lieberman J., Liu Q. and Song E., Blocking the Recruitment of Naïve CD4+ T Cells Reverses Immunosuppression in Breast Cancer, Cell Research. 2017, 27(4): 461-482.

XU C., LIN Q., DENG J., Yu B., ARYA S. and Huang J., Live attenuated Salmonella-based Vaccines delivering SaEsxA by Type III Secretion System Confer Protection against Staphylococcus aureus Infection, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

ZHANG B., Cai J., Yu B., HUA Y., Lau C.Y., Kao R.Y.T., Sze K.H., Yuen K.Y. and Huang J., A DNA vaccine targeting TcdA and TcdB induces protective immunity against Clostridium difficile, BMC Infectious Diseases. 2016, 16.

ZHOU N., ZHAO Y.F., AGNESE C., Tanner J.A., ADRIAN D. and Huang J., Synthetic Multicellular Systems for Spontaneous Pattern Formation, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : Huen MSY

Project Title:	Study Role of PCNA-binding protein TRAIP in Replicative Stress Responses and Tumor Suppression
Investigator(s):	Huen MSY, Feng W
Department:	School of Biomedical Sciences
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2014

Project Title:	Examining Negative Regulatory Mechanisms of DNA Damage Signal Transduction & Their Impact on Maintenance of Genome Stability
Investigator(s):	Huen MSY
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	Role of UBE2U in DNA Damage Signaling and Repair
Investigator(s):	Huen MSY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2015

Project Title:	Role of Human Ubiquitin Machineries in DNA Damage Signaling and Repair
Investigator(s):	Huen MSY
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016

Project Title:	Outstanding Young Researcher Award 2014-15
Investigator(s):	Huen MSY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	02/2016

Project Title:	Why does TRAIP/RNF206 Inactivation cause Microcephalic Primordial Dwarfism
Investigator(s):	Huen MSY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Funding for Incubating Group-based Collaborative Research Projects
Start Date:	03/2016

Project Title:	Role of HAUSP in DNA Damage Signal Transduction
Investigator(s):	Huen MSY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016
Completion Date:	12/2017

Project Title:	Exploiting the potential of cyro-EM for structure-based drug design: Targeting ATM for therapeutic intervention in cancer and degenerative diseases
Investigator(s):	Huen MSY, Lau CYW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Translational and Applied Research
Start Date:	06/2016

Project Title:	Role of The USP7-RNF169 Axis in DNA Double-Strand Break Responses
Investigator(s):	Huen MSY
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2016

Project Title:	Role of The BRCA1-A Complex in DNA Repair Control
Investigator(s):	Huen MSY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

List of Research Outputs

AN L., Jiang Y.Y., Ng H.W.H., Chen J., Gong Q.G. and Huen M.S.Y., A Dual Utility NLS Drives RNF169-dependent DNA Damage Responses, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

AN L., JIANG Y., Ng H.W.H., Man P.S., CHEN J., Khoo U.S., Gong Q. and Huen M.S.Y., Dual-utility NLS Drives RNF169-dependent DNA Damage Responses, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

An L., Jiang Y., Ng H.L.L., Man P.S., Chen J., Khoo U.S., Gong Q. and Huen M.S.Y., Dual-utility NLS drives RNF169-dependent DNA damage responses, Proc Natl Acad Sci U S A. 2017, 114(14): E2872-E2881.

Chen H., Gu X.H., Zhou Y., Ge Z., Wang B., Siok W.T., Wang G., Huen M.S.Y., Jiang Y., Tan L.H. and Sun Y., A Genome-Wide Association Study Identifies Genetic Variants Associated with Mathematics Ability, Scientific Reports. 2017, 7: 40365.

GUO Y., AN L., NG H.M., Sy M.H. and Huen M.S.Y., An E2-guided E3 Screen Identifies the RNF17-UBE2U Pair as Regulator of the Radiosensitivity, Immunodeficiency, Dysmorphic Features, and Learning Difficulties (RIDDLE) Syndrome Protein RNF168., Journal Of Biological Chemistry. 2017, 292: 967-978.

Huen M.S.Y., Self-Restraining Mechanisms of DNA Damage Surveillance and Repair, Gordon Research Conference Genomic Instability. 2016.

Ng H.M., Wei L., Lan L. and Huen M.S.Y., The Lys63-deubiquitylating Enzyme BRCC36 Limits DNA Break Processing and Repair , Journal of Biological Chemistry. 2016, 291: 16197-16207.

Researcher : Hui CC

List of Research Outputs

HO C.C., QIN T., Wang B., Wong Y.M.E., LIU Y., Hui C.C. and Sham M.H., Sufu controls the proliferation and differentiation of cochlear prosensory progenitors, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

HO C.C., QIN T., Wang B., Wong Y.M.E., LIU Y., Hui C.C. and Sham M.H., Sufu regulates the proliferation and differentiation of hair cell progenitors in mammalian cochlea, 18th International Congress of Developmental Biology. 2017.

LIU Y., Wang B., Wong Y.M.E., Tsang S.L., HO C.C., Hui C.C. and Sham M.H., The roles of Irx3 and Irx5 in inner ear neurosensory patterning, 18th International Congress of Developmental Biology. 2017.

LIU Y., Wang B., Wong Y.M.E., Tsang S.L., HO C.C., Hui C.C. and Sham M.H., The roles of Irx3 and Irx5 in inner ear neurosensory patterning, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

PAN W., HO H.H., Hui C.C. and Sham M.H., Regulation of mammalian hindbrain neural progenitor proliferation and differentiation by Suppressor of fused and β-catenin, 18th International Congress of Developmental Biology. 2017.

PAN W., HOR H.H.C., Hui C.C. and Sham M.H., Suppressor of fused regulates neural progenitor cell cycle progression during mammalian hindbrain neurogenesis, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : Hung HLC

List of Research Outputs

Chang R.C.C., YOU R., Hung H.L.C. and Ho Y.S., Environmental pollutants as risk factos for developing cognitive dysfunctions and Alzheimer’s disease. , The 10th Annual Scientific Meeting of Hong Kong Society of Biological Psychiatry: Brain and the Environment II. . 2017, 13.

SHAH A.N., Hung H.L.C., Cheng S.Y., WONG M.Y., Legido-Quigley C. and Chang R.C.C., Oxyresveratrol mitigates cellular toxicity in and in-vitro and in-vivo model of Parkinson’s disease, The 13th International Conference on Alzheimer’s & Parkinson’s Diseases 2017, Section C02.g Therapeutic targets, mechanisms for treatment: anti- inflammatory, anti-oxidant.. 2017, 146.

YOU R., Ho Y.S., Hung H.L.C. and Chang R.C.C., Evaluating the implication of silica nanoparticles in neurodegeneration, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

YOU R., Hung H.L.C., Ho Y.S. and Chang R.C.C., Investigating the effects of silica nanoparticles on neurodegeneratioive-like changes in behaviors and neuropathology. , International Alzheimer’s Disease Conference 2017. 40.

YOU R., Ho Y.S., Hung H.L.C., Lai S.W.C. and Chang R.C.C., Investigating the effects of slicia nanoparticles as affective and cognitive behaviors. , The 12th International Symposium on Healthy Aging. 2017, 50.

Researcher : IEONG IL

List of Research Outputs

IEONG I.L., GHOSH S. and Zhou Z., Characterization of KAP1 acetylation and its roles in DNA damage repair, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : JIANG Q

List of Research Outputs

JIANG Q., Chen W., Shum D.K.Y. and Chan Y.S., Antidepressant Reinstates the Plasticity of Vestibular-mediated Navigation in the Adult, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

JIANG Q., Ma C.W., Shum D.K.Y. and Chan Y.S., Antidepressant reactivates the plasticity of vestibular-dependent navigation in the adult, Soc. Neuroscience Abstract (USA) , 264.14 [San Diego. Nov. 12-16, 2016]. 2016.

JIANG Q. and Chan Y.S., Antidepressant reinstates the plasticity of vestibular-mediated navigation in the adult. [Oral presentation at the Gordon Research Seminar on Molecular & Cellular Neurobiology – Novel Approaches & New Advancement in Neural Development, Plasticity, and Diseases June 11-12, 2016. 2016.

JIANG Q., Ma C.W., Shum D.K.Y. and Chan Y.S., Antidepressant reinstates the plasticity of vestibular-mediated navigation in the adult, Abstracts of 12^th Int’l Symp. on Healthy Aging: Science and Aging – Wellness and Longevity: From Science to Service: 61. [HK. March 11-12, 2017]. 2017.

Researcher : JIANG Y

List of Research Outputs

JIANG Y., LAM T.F., Ma C.W., Shum D.K.Y., WANG J.J. and Chan Y.S., Modulatory role of orexin on synaptic transmission in the central vestibular system, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

JIANG Y., Lam T.F.U., Ma C.W., Shum D.K.Y., Wang J.J. and Chan Y.S., Modulatory role of orexin on synaptic transmission in the central vestibular system, Soc. Neuroscience Abstract (USA), 803.04 [San Diego. Nov. 12-16, 2016]. 2016.

JIANG Y., LAM T.F., Ma C.W., Shum D.K.Y., Wang J.J. and Chan Y.S., Orexin regulates synaptic transmission within the rat vestibular nucleus, Abstracts of 12^th Int’l Symp. on Healthy Aging: Science and Aging – Wellness and Longevity: From Science to Service : 64. [HK. March 11-12, 2017]. 2017.

Researcher : Jia LJ

Project Title:	Keystone Symposia Conference on Tumor Metabolism: Mechanisms and Targets; Hypoxia induces lytic reactivation of Epstein-Barr virus in stable M81-infected nasopharyngeal epithelial cells
Investigator(s):	Jia LJ
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2017

List of Research Outputs

Jia L.J., Tsang C.M., Yip Y.L., ZHANG J., Deng W. and Tsao G.S.W., Establishment and characterization of immortalized nasopharyngeal epithelial cells with stable infection of Epstein-Barr virus, 4th International Anatomical Sciences & Cell Biology Conference. 2016.

Jia L.J., Tsang C.M., Yip Y.L., Law W.T., ZHANG J., Deng W. and Tsao G.S.W., Establishment and characterization of immortalized nasopharyngeal epithelial cells with stable infection of Epstein-Barr virus, AMPK 2016: New Mechanism and Physiology. 2016.

Jia L.J., ZHANG J., Yip Y.L., Lin W., Jin D., Tsang C.M. and Tsao G.S.W., Hypoxia induces lytic reactivation of Epstein-Barr virus in stable M81-infected nasopharyngeal epithelial cells, Keystone Symposia Conference on Tumor Metabolism: Mechanisms and Targets. 2017.

Jia L.J., Poster Award, 4th International Anatomical Sciences & Cell Biology Conference . 2016.

Li Y.Y., Chung G.T., Lui W.Y.V., To K.F., Ma B.B., Chow C., Woo J.K., Yip K.Y., Seo J., Hui E.P., Mak M.K., Rusan M., Chau N.G., Or Y.Y., Law M.H., Law P.P., Liu Z.W., NGAN H.L., Hau P.M., Verhoeft K.R., Poon P.H., Yoo S.K., Shin J.Y., Lee S.D., Lun S.W., Jia L.J., Chan A.W., Chan J.Y., Lai P.B., Fung C.Y., Hung S.T., Wang L., Chang A.M., Chiosea S.I., Hedberg M.L., Tsao G.S.W., van Hasselt A.C., Chan A.T., Grandis J.R., Nature Communications P.S. and Lo K.W., Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations, Nature Communications. 2017.

Tsao G.S.W., ZHANG J., Jia L.J., Tsang C.M., Lin W., Yip Y.L., Deng W., Lo K.W. and Lung M.L., The role of EBV infection in aerobic glycolysis in nasopharyngeal carcinoma., AACR Annual Meeting 2017.

ZHANG J., Jia L.J., Lin W., Yip Y.L., LAU V.M.-.Y., Zhu D., Tsang C.M., Zhou Y.L., Deng W., Lung H.L., Lung M.L., Cheung A. and Tsao G.S.W., Epstein-Barr Virus Encoded Latent Membrane Protein-1 Induces Glucose Transporter-1 Transcription is Dependent on the mTORC1 Mediated NF-κB Pathway Activation, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

ZHANG J., Jia L.J., Lin W., Yip Y.L., Lo K.W., LAU V.M.-.Y., Zhu D., Tsang C.M., Zhou Y., Deng W., Lung H.L., Lung M.L., Cheung L.M. and Tsao G.S.W., Epstein-barr Virus-encoded Latent Membrane Protein 1 Upregulates Glucose Transporter 1 Transcription Via The Mtorc1/nf-κb Signaling Pathways, Journal of Virology. 2017, 91: e02168-16.

Researcher : Jin D

Project Title:	Mitotic checkpoint and genomic stability in ovarian cancer
Investigator(s):	Jin D
Department:	School of Biomedical Sciences
Source(s) of Funding:	National Institutes of Health, US Department of Health and Human Services - General Award
Start Date:	09/2002

Project Title:	Outstanding Researcher Award 2007-2008
Investigator(s):	Jin D
Department:	Biochemistry
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	10/2008

Project Title:	4th Intracellular Proteolysis Meeting on Ubiquitin-proteasome System, Dynamics and Targeting REV7-mediated polyubiquitination and degradation of human REV1
Investigator(s):	Jin D
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2009

Project Title:	Knockdown of miR-BART5 in Epstein-Barr Virus-infected Cells by RNA Decoys Delivered through Novel Adenoviral Vectors: a New Paradigm for Cancer Therapy
Investigator(s):	Jin D, Kok KH, Lei T
Department:	School of Biomedical Sciences
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	01/2010

Project Title:	Knockdown of miR-BART5 in Epstein-Barr Virus-infected Cells by RNA Decoys Delivered through Novel Adenoviral Vectors: a New Paradigm for Cancer Therapy
Investigator(s):	Jin D
Department:	School of Biomedical Sciences
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	01/2010

Project Title:	Knockdown of miR-BART5 in Epstein-Barr Virus-infected Cells by RNA Decoys Delivered through Novel Adenoviral Vectors: a New Paradigm for Cancer Therapy
Investigator(s):	Jin D
Department:	School of Biomedical Sciences
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	01/2010

Project Title:	Mapping of peptide sequence in swine-origin H1N1 influenza virus hemagglutinin associated with the induction of anti-ganglioside antibodies implicated in Guillain-Barre syndrome: a pilot study
Investigator(s):	Jin D, Zheng B
Department:	School of Biomedical Sciences
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2011

Project Title:	Molecular dissection of NSs virulence factor in severe fever with thrombocytopenia syndrome virus (SFTSV), a novel bunyavirus identified in China
Investigator(s):	Jin D, Kok KH
Department:	Biochemistry
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2013
Completion Date:	12/2016

Project Title:	Roles of CRTC coactivators in hepatitis B virus X protein-mediated activation of CREB-dependent transcription
Investigator(s):	Jin D, Zheng B, Zhou J, Tang HMV
Department:	Biochemistry
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2013
Completion Date:	10/2016

Project Title:	Regulatory roles of SIRT1 deacetylase in hepatitis B virus transcription
Investigator(s):	Jin D, Zhou J, Tang HMV
Department:	Biochemistry
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2014
Completion Date:	02/2017

Project Title:	Mechanism of inflammasome activation by SARS coronavirus 3a protein
Investigator(s):	Jin D, Zheng B, Tang HMV
Department:	Biochemistry
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2014
Completion Date:	02/2017

Project Title:	Outstanding Research Student Supervisor Award 2013-14
Investigator(s):	Jin D
Department:	Biochemistry
Source(s) of Funding:	Outstanding Research Student Supervisor Award
Start Date:	12/2014

Project Title:	Identification and characterization of human cyclic dinucleotide phosphodiesterases that hydrolyze cGAMP second messenger
Investigator(s):	Jin D, Tse H
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	Suppression of innate interferon production by Middle East respiratory syndrome coronavirus M protein
Investigator(s):	Jin D, Yeung ML
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2015

Project Title:	Identification and characterization of a novel transcript isoform of STING that negatively regulates innate antiviral response
Investigator(s):	Jin D, Yang W, Deng J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2016

Project Title:	Suppression of hepatitis B virus transcription by LKB1 and salt-inducible kinases
Investigator(s):	Jin D, Deng J, Kong KY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2016

Project Title:	Molecular Mechanism of PACT-dependent Innate Antiviral Response
Investigator(s):	Jin D, Chan CP, Sham MH, Yeung ML, Yuen KY, Zheng B, Zhou J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2016

Project Title:	Perturbation of MAVS-dependent antiviral response by PB1-F2 protein of influenza A (H7N9) virus and implications to viral pathogenesis
Investigator(s):	Jin D, Chen H, Chan CP
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2016

Project Title:	Frontiers of Retrovirology Conference 2016; Perturbation of innate RNA and DNA sensing by human T-cell leukemia virus type 1 oncoproteins
Investigator(s):	Jin D
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2016
Completion Date:	09/2016

Project Title:	Identification and characterization of MDM2 as an E3 ubiquitin ligase for STAT2 activated by Zika virus NS5 protein
Investigator(s):	Jin D, Yuen KS, Wang F
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2017

Project Title:	Roles of BART non-coding RNAs in Epstein-Barr virus infection and oncogenesis (CRF)
Investigator(s):	Jin D
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Funding for Strategic Interdisciplinary Research Scheme
Start Date:	06/2017

List of Research Outputs

. S., Botelho M.G. and Jin D., American Society for Virology Student Travel Award 2017, American Society for Virology. 2017.

. S., Yuen K.S., WONG N.H.M., CHENG T.F., Botelho M.G. and Jin D., CRISPR/Cas9 targeting of viral essential genes suppresses Epstein- Barr virus DNA load in nasopharyngeal carcinoma cells of latency II., The American Society for Virology 36th Annual Meeting, University of Wisconsin-Madison, Madison, Wisconsin, USA, June 23-28, 2017.. 2017.

CHAUDHARY V. and Jin D., American Society for Virology Student Travel Award 2017, American Society for Virology. 2017.

CHAUDHARY V., Zhang S., Yuen K.S., Li D., Kok K.H., Liang M. and Jin D., Differential modulation of type I and type II interferon signaling by severe fever-with-thrombocytopenia syndrome virus NSs protein., 2016 World Life Science Conference. Beijing, China, 2016.

CHAUDHARY V., ZHANG S., LI D., LIANG M., Kok K.H. and Jin D., Dual regulatory effects of SFTS virus NSs protein on interferon signaling, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

CHAUDHARY V., Yuen K.S., Chan J.F.W., Chan C.P., Kok K.H., Chan C.P., Yuen K.Y. and Jin D., Selective activation of interferon-γ signaling by Zika virus NS5 protein (invited speaker)., 2016 World Life Science Conference.. Beijing, China, 2016.

CHAUDHARY V., Zhang S., Yuen K.S., Li D., Liang M.F. and Jin D., Severe fever-with-thrombocytopenia syndrome virus NSs protein exerts opposite regulatory roles on type I and type II interferon signaling., The American Society for Virology 36th Annual Meeting, University of Wisconsin-Madison, Madison, Wisconsin, USA, June 23-28, 2017.. 2017.

CHAUDHARY V., Yuen K.S., Chan J.F.W., Chan C.P., Wang F., Kok K.H., Chan C.P., Yuen K.Y. and Jin D., Zika virus NS5 protein differentially modulates type I and type II interferon signaling., Cross Street Immunology Conference, National Taiwan University, Taipei, March 18-19, 2017.. 2017.

CHENG T.F. and Jin D., Caspase 3 activation and apoptosis facilitates lytic induction of Epstein- Barr virus in epithelial cells, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

CHENG Y., GAO W., Tang H.M.V. and Jin D., β-TrCP targets liver-enriched and membrane-bound transcription factor CREB-H for ubiquitination and degradation., 16th International Union of Biochemistry and Molecular Biology (IUBMB) Conference: Signaling Pathways in Development, Diseases and Aging.. Vancouver, Canada, 2016.

Chan C.P., Yuen C.K.J., Fung S.Y., CHEUNG P.H.H., Chen H., Kok K.H. and Jin D., Antiviral activity of double-stranded RNA-binding protein PACT against influenza A virus mediated through suppression of viral RNA polymerase, FOCIS 2017.

Chan J.F.W., Zhang J., Chan C.S., Yip C.Y., Mak W.N., Zhu H., Poon K.M., Tee K.M., Zhu Z., Cai J., Tsang O.L., Chik K.K.H., Yin F., Chan K.H., Kok K.H., Jin D., Au Yeung K.H.R. and Yuen K.Y., Characterization of a novel mouse model for Zika virus infection using dexamethasone-immunosuppressed mice, First International Conference on Zika Virus. 2017.

Chan J.F.W., Yip C.Y., Tsang O.L., Tee K.M., Cai J., Chik K.K.H., Zhu Z., Chan C.S., CHOI K.Y., Sridhar S., Zhang J., Lu G., Chiu K., Lo A.C.Y., Tsao G.S.W., Kok K.H., Jin D., Chan K.H. and Yuen K.Y., Differential cell line susceptibility to the emerging Zika virus: implications for disease pathogenesis, non-vector-borne human transmission and animal reservoirs, Emerging Microbes & Infections. 2016, 5: e93.

Chan J.F.W., Zhang J., Chan C.S., Yip C.Y., Mak W.N., Zhu H., Poon K.M., Tee K.M., Zhu Z., Cai J., Tsang O.L., Chik K.K.H., Yin F., Chan K.H., Kok K.H., Jin D., Au Yeung K.H.R. and Yuen K.Y., Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons, EBioMedicine. 2016, 14: 112-122.

Chaudhary V., Yuen K.S., Chan J.F.W., Chan C.P., Wang F., Cai J., Zhang S., Liang M., Kok K.H., Chan C.P., Yuen K.Y. and Jin D., Selective activation of type II interferon signaling by Zika virus NS5 protein, J Virol. 2017, 91(14): e00163-17.

Deng J. and Jin D., 2016 International HBV Meeting Travel Award, 2016 International HBV Meeting. 2016.

Deng J., Kong K.Y., Gao W., Tang H.M.V., CHAUDHARY V., CHENG Y., Zhou J., Chan C.P., Wong D.K.H., Yuen R.M.F. and Jin D., Interplay between SIRT1 and hepatitis B virus X protein in the activation of viral transcription, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 2017, 1860: 491-501.

Deng J., Kong K.Y., GAO W., Tang H.M.V., Chan C.P. and Jin D., Sirtuins are potent activators of hepatitis B virus transcription., 2016 International HBV Meeting.. Seoul, Korea, 2016.

FUNG S.Y., YUEN C.K., ZHU W., LIANG G., Kok K.H., Chan C.P. and Jin D., Activation of nucleic acid sensing cGAS-STING pathway by Sindbis Virus, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

FUNG S.Y., Chan C.P., YUEN C.K., Kok K.H., Chan C.P. and Jin D., Human T-cell leukemia virus type 1 Tax and HBZ proteins differentially suppress RNA- and DNA-induced innate antiviral response., 18th International Conference on Human Retrovirology: HTLV-1 and Related Viruses, Tokyo, Japan, March 7-10, 2017.. 2017.

GAO W., Tang H.M.V., CHENG Y., WANG P. and Jin D., Regulation of ubiquitination and degradation of CRTC1 transcriptional coactivator by salt-inducible kinase SIK1., 16th International Union of Biochemistry and Molecular Biology (IUBMB) Conference: Signaling Pathways in Development, Diseases and Aging.. Vancouver, Canada, 2016.

Jia L.J., ZHANG J., Yip Y.L., Lin W., Jin D., Tsang C.M. and Tsao G.S.W., Hypoxia induces lytic reactivation of Epstein-Barr virus in stable M81-infected nasopharyngeal epithelial cells, Keystone Symposia Conference on Tumor Metabolism: Mechanisms and Targets. 2017.

Jin D., Molecular arms race between virus and host innate immunity: PACT as an example., Taiwan Society of Virology Special Conference on Innate Immunity to Viral Infections: Focus on Interferon, National Taiwan University, Taipei, May 6, 2017.. 2017.

Jin D., GAO W., Deng J., Kong K.Y. and Chan C.P., Suppression of hepatitis B virus transcription by LKB1 tumor suppressor and salt-inducible kinases, 2016 International HBV Meeting. Seoul, Korea, 2016.

Jin D., CHAUDHARY V., Yuen K.S., Chan J.F.W., Chan C.P. and Yuen K.Y., Zika virus NS5 protein suppresses type I and type III interferon signaling but augments type II interferon signaling., The American Society for Virology 36th Annual Meeting, University of Wisconsin-Madison, Madison, Wisconsin, USA, June 23-28, 2017.. 2017.

Kong K.Y. and Jin D., 2016 International HBV Meeting Full Travel Award, 2016 International HBV Meeting. 2016.

Kong K.Y., Deng J., GAO W., Tang H.M.V., CHAUDHARY V., CHENG Y., Wong D.K.H., Yuen R.M.F., Ma S.K.Y., Chan C.P. and Jin D., PRMT5 protein arginine methyltransferase activates hepatitis B virus transcription., 2016 International HBV Meeting.. Seoul, Korea, 2016.

Rezelj V.V., Li P., CHAUDHARY V., Elliott R.M., Jin D. and Brennan B., Differential Antagonism of Human Innate Immune Responses by Tick-Borne Phlebovirus Nonstructural Proteins , mSphere. 2017, 2: e00234-17.

Verhoeven R.J.A., TONG S., Zhang G.H., Zong J.F., Chen Y.X., Jin D., Chen M.R., Pan J.J. and Chen H., NF-κB Signaling Regulates Expression of Epstein-Barr Virus BART MicroRNAs and Long Noncoding RNAs in Nasopharyngeal Carcinoma, Journal of Virology. USA, AMER SOC MICROBIOLOGY, 2016, 90: 6475-6488.

WONG N.H.M., Yuen K.S., Chan C.P. and Jin D., Suppression of IFN-β production by Epstein-Barr virus lytic transactivator Zta., Immunology 2017 – The American Association of Immunologists Meeting, Walter E. Washington Convention Center, Washington, D.C., USA, May 12-16, 2017.. 2017.

Wang F. and Jin D., A Novel Transcript Isoform of IFI16 Attenuates Inflammasome Activation Mediated by the Cytoplasmic DNA Sensor AIM2, American Society for Virology 36th Annual Meeting . 2017.

Wang F. and Jin D., A Novel Transcript Isoform of IFI16 Attenuates Inflammasome Activation Mediated by the Cytosolic DNA Sensor AIM2, Annual Scientific Meeting of the Hong Kong Society for Immunology 2016.

Wang F. and Jin D., American Society for Virology Postdoc Travel Award 2017, American Society for Virology. 2017.

Wang F., FUNG S.Y., Chan C.P. and Jin D., Induction by HTLV-1 of a transcript isoform of STING that suppresses innate antiviral response., 18th International Conference on Human Retrovirology: HTLV-1 and Related Viruses, Tokyo, Japan, March 7-10, 2017.. 2017.

Wang F. and Jin D., Poster Presentation Award of Annual Scientific Meeting of the Hong Kong Society for Immunology 2016, the Hong Kong Society for Immunology. 2016.

Yuen K.S., WONG N.H.M. and Jin D., CRISPR/Cas9-facilitated construction of a bacterial artificial chromosome clone of Epstein-Barr virus from C666-1 nasopharyngeal carcinoma cells., 17th International Symposium on Epstein Barr Virus and Associated Diseases (EBV2016). Zurich, Switzerland, 2016.

Yuen K.S., Chan C.P., Kok K.H. and Jin D., Mutagenesis and genome engineering of Epstein-Barr virus in cultured human cells by CRISPR/Cas9., Methods in Molecular Biology. 2016, 1498: 23-31.

Yuen K.S., Wang Z.M., WONG N.H.M., Zhang Z.Q., CHENG T.F., LUI W.Y., Chan C.P. and Jin D., Suppression of Epstein-Barr virus DNA load in latently infected nasopharyngeal carcinoma cells by CRISPR/Cas9, Virus Res.. 2017.

Yuen K.S., WONG N.H.M. and Jin D., Suppression of Epstein-Barr virus infection in nasopharyngeal carcinoma cells through CRISPR/Cas9 targeting of EBNA1, OriP and W repeats, In: Christian Münz, 17th International Symposium on EBV and associated diseases. 2016.

Researcher : Jin J

List of Research Outputs

Wang Y., Fung E.Y.M., ZHANG W., He B., CHUNG W.H., Jin J., Hu J., Lin H.N. and Hao Q., Deacylation Mechanism by SIRT2 Revealed in the 1′-SH-2′-O-Myristoyl Intermediate Structure, Cell Chemical Biology. 2017, 24: 339-345.

Researcher : KHONG ML

List of Research Outputs

KHONG M.L., LI L., SOLESIO M.E.T., LANG Y.P., PAVLOV E. and Tanner J.A., Inorganic Polyphosphate Influences Cyclophilin B-Mediated Protein Folding In Osteoblasts, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

KHONG M.L., Li L. and Tanner J.A., Inorganic polyphosphate is a fundamental molecule in osteoblasts: from interactions to functions, 41st Annual Conference of the Malaysian Society for Biochemistry & Molecular Biology, Kuala Lumpur, Malaysia. 2016.

KHONG M.L., Li L., Lang C.Y.P. and Tanner J.A., Inorganic polyphosphate – a mediator of protein folding in osteoblasts via interaction with cyclophilin B, American Society for Biochemistry and Molecular Biology (ASBMB) Annual Meeting. 2017.

KHONG M.L., Li L., Lang C.Y.P. and Tanner J.A., Translating Polyphosphate-Cyclophilin B Interaction to an Understanding of Polyphosphate’s Role in Protein Folding, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

Lang C.Y.P., KHONG M.L., Li L. and Tanner J.A., Elucidating human cyclophilin B properties as a polyphosphate-binding protein, National Collegiate Research Conference, Harvard University, Boston. 2017.

Lui E.L.H., AO K.L., Li L., KHONG M.L. and Tanner J.A., Inorganic polyphosphate triggers upregulation of interleukin 11 in human osteoblast-like SaOS-2 cells, Biochemical and Biophysical Research Communications. 2016, 479: 766-771.

Researcher : KINGHORN AB

List of Research Outputs

BHUYAN S.K., Kinghorn A.B., TANG Y.H., Shum H.C. and Tanner J.A., A high throughput approach for discovery of catalytic nucleic acids, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Cheung Y.W., SHIU C.C., FRASER L.A., LIANG S., Dirkzwager R.M., Kinghorn A.B., TANG S.L.M. and Tanner J.A., Aptamer-mediated biosensing: from malaria diagnosis to DNA nanostructure dynamics, 5th International Conference on Bio-Sensing Technology. 2017.

Cheung Y.W., SHIU C.C., Wong W.C., TANG S.L.M., DIRKZWAGER R.M., LIANG S., KINGHORN A.B., FRASER L.A. and Tanner J.A., From DNA aptamer structure to splitting for use in DNA nanotweezers, Oligo 2017 Oxford: Antisense & Therapeutic Nucleic Acids. 2017.

FRASER L.A., Kinghorn A.B., Dirkzwager R.M., Cheung Y.W., Richards J. and Tanner J.A., 3D Printed Microfluidics for Point of Care Malaria Diagnosis, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

KINGHORN A.B., DIRKZWAGER R.M., LIANG S., Cheung Y.W., FRASER L.A., SHIU C.C., TANG S.L.M. and Tanner J.A., Aptamer Affinity Maturation by Resampling and Microarray Selection, Analytical Chemistry. American Chemical Society, 2016, 88: 6981-6985.

Kinghorn A.B., Software: Resample web, a hosted webservice for Aptamer Affinity Maturation library generation, 2016.

SHIU C.C., Cheung Y.W., DIRKZWAGER R.M., LIANG S., Kinghorn A.B., FRASER L.A., TANG S.L.M. and Tanner J.A., A split aptamer can facilitate protein recognition in DNA nanotweezers, Aptamers 2017, 4th Oxford Symposium on Aptamers. 2017.

SHIU C.C., Cheung Y.W., LIANG S., Kinghorn A.B., LIANG S., TANG S.L.M. and Tanner J.A., An Aptamer-Mediated DNA Nano-Switch, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

SHIU C.C., Cheung Y.W., DIRKZWAGER R.M., LIANG S., Kinghorn A.B., FRASER L.A., TANG S.L.M. and Tanner J.A., Aptamer-Mediated Protein Molecular Recognition Driving a DNA Tweezer Nanomachine, Advanced Biosystems. 2017, 1: 1600006.

SHIU C.C., Cheung Y.W., Dirkzwager R.M., LIANG S., Kinghorn A.B., FRASER L.A., Tang S.L.M. and Tanner J.A., DNA Tweezer Nanomachine Mediated by Heterogeneous Recognition, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

SHIU C.C., TANG S.L.M., DIRKZWAGER R.M., LIANG S., Kinghorn A.B., Cheung Y.W., FRASER L.A., Godonoga M., Heddle J.G. and Tanner J.A., Protein driven aptamer toehold switches integrated into DNA origami nanostructures, Oligo 2017 Oxford: Antisense & Therapeutic Nucleic Acids. 2017.

Tanner J.A. and KINGHORN A.B., DNA DISPLAY AND METHODS THEREOF, WIPO Patent WO/2016/134521. 2016, CN2015/073350.

Researcher : KWAN PY

List of Research Outputs

KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Role of perineuronal chondroitin sulfates and semaphorin3A in the maturation of the vestibular circuitry, Abstracts of 10^th FENS Forum of Neuroscience, 2349. [Copenhagen, Denmark. July 2-6, 2016]. 2016.

Shum D.K.Y., KWAN P.Y., Ma C.W. and Chan Y.S., The regulatory roles of perineuronal semaphorin 3A and chondroitin sulfates on the developing vestibular circuitry, Soc. Neuroscience Abstract (USA), 677.17 [San Diego. Nov. 12-16, 2016]. 2016.

Researcher : KWON YJ

List of Research Outputs

KWON Y.J., Chan W.C.W. and Chan D., Postnatal Expression of Pax1 in the Intervertebral Disc during Postnatal Growth and Response to Spinal Curvature, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : Keung WWY

Project Title:	Driving maturation of human embryonic stem cell-derived cardiomyocytes through metabolic conditioning in 2D and 3D environment
Investigator(s):	Keung WWY
Department:	Physiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	09/2014
Completion Date:	09/2016

Project Title:	Modeling cardiomyopathy with 3D cardiac tissue constructs of patient specific induced-pluripotent stem cells
Investigator(s):	Keung WWY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2016

List of Research Outputs

Keung W.W.Y., Ren L., Li S., Wong A.O., Chopra A., Kong M.C.W., Tomaselli G.F., Chen C.S. and Li R.A., Non-cell autonomous cues for enhanced functionality of human embryonic stem cell-derived cardiomyocytes via maturation of sarcolemmal and mitochondrial KATP channels, Scientific Reports. 2016, 6: 34154.

Shin S.R., Zhang Y.S., Kim D.-.J., Manbohi A.L., Avci H., Silvestri A., Aleman J., Hu N., Kilic T., Keung W.W.Y., Righi M., Assawes P., Alhadrami H.A., Li R.A., Dokmeci M.R. and Khademhosseini A., Aptamer-Based Microfluidic Electrochemical Biosensor for Monitoring Cell-Secreted Trace Cardiac Biomarkers, Analytical Chemistry. 2016.

Tse G., Liu T., Li K.H., Laxton V., Chan Y.W., Keung W.W.Y., Li R.A. and Yan B.P., Electrophysiological Mechanisms of Brugada Syndrome: Insights from Pre-clinical and Clinical Studies, Frontiers in Physiology. 2016, 7.

Ussher J.R., Fillmore N., Keung W.W.Y., Zhang L., Mori J., Sidhu V.K., Arata F., Keshav G., Lopaschuk D.G., Wagg C.S., Jaswal J.S., Dyck J.R.B. and Lopaschuk G.D., Genetic and Pharmacological Inhibition of Malonyl CoA Decarboxylase Does Not Exacerbate Age-Related Insulin Resistance in Mice, Diabetes. 2016, 65: 1883-1891.

Researcher : Kinghorn AB

List of Research Outputs

Kinghorn A.B., Software: Resample web, a hosted webservice for Aptamer Affinity Maturation library generation, 2016.

Tanner J.A. and KINGHORN A.B., DNA DISPLAY AND METHODS THEREOF, WIPO Patent WO/2016/134521. 2016, CN2015/073350.

Researcher : Kong KY

List of Research Outputs

Deng J., Kong K.Y., Gao W., Tang H.M.V., CHAUDHARY V., CHENG Y., Zhou J., Chan C.P., Wong D.K.H., Yuen R.M.F. and Jin D., Interplay between SIRT1 and hepatitis B virus X protein in the activation of viral transcription, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 2017, 1860: 491-501.

Deng J., Kong K.Y., GAO W., Tang H.M.V., Chan C.P. and Jin D., Sirtuins are potent activators of hepatitis B virus transcription., 2016 International HBV Meeting.. Seoul, Korea, 2016.

Jin D., GAO W., Deng J., Kong K.Y. and Chan C.P., Suppression of hepatitis B virus transcription by LKB1 tumor suppressor and salt-inducible kinases, 2016 International HBV Meeting. Seoul, Korea, 2016.

Kong K.Y. and Jin D., 2016 International HBV Meeting Full Travel Award, 2016 International HBV Meeting. 2016.

Kong K.Y., Deng J., GAO W., Tang H.M.V., CHAUDHARY V., CHENG Y., Wong D.K.H., Yuen R.M.F., Ma S.K.Y., Chan C.P. and Jin D., PRMT5 protein arginine methyltransferase activates hepatitis B virus transcription., 2016 International HBV Meeting.. Seoul, Korea, 2016.

Researcher : Kong MCW

List of Research Outputs

ZHANG W., Kong M.C.W., TONG M., TONG M., HUANG N., Li R.A. and Chan B.P., Maturation of human embryonic stem cell-derived cardiomyocytes (hESC-CMs) in 3D collagen matrix: Effects of niche cell supplementation and mechanical stimulation, Acta Biomaterialia. 2017, 49: 204-217.

Researcher : Kudelko MA

Project Title:	Cartilage Biology & Pathology Gordon Research Conference and seminar Understanding Biology to Achieve Better Cartilage Health; Proteomic Landscape of murine intervertebral disc reveals mechanisms involved in homeostasis and disc structure maintenance
Investigator(s):	Kudelko MA
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2017
Completion Date:	04/2017

List of Research Outputs

SO K.H., Kudelko M.A., Tan Z., Wang C., Chan W.C.W., Tsang K.Y., Cheah K.S.E. and Chan D., FGF21 Up-Regulates Glycolytic Proteins for Hypertrophic Chondrocyte Survival under ER Stress, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : Kwok LF

List of Research Outputs

Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Immobilised Chondroitinase ABC Promotes Axonal Regrowth in Lesioned Spinal Cord, 12^th International Symposium on Healthy Aging--Wellness and Longevity: From Science to Service. 2017, P9: 63.

Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Immobilised chondroitinase ABC promotes axonal regrowth in lesioned spinal cord, Abstracts of 12^th Int’l Symp. on Healthy Aging: Science and Aging Wellness and Longevity: From Science to Service : 63. [HK. March 11-12, 2017]. 2017.

Researcher : LAM CS

List of Research Outputs

Kang J.J., Liang W.H., Lam C.S., Huang X.F., Yang S.J., Wong-Riley M.T., Fung M.L. and Liu Y.Y., Catecholaminergic neurons in synaptic connections with pre-Botzinger complex neurons in the rostral ventrolateral medulla in normoxic and daily acute intermittent hypoxic rats, Experimental Neurology. 2017, 287: 165-175.

LAM C.S., Tipoe G.L., Wong K.C., Youdim M.B.H. and Fung M.L., M30 Antagonizes Indoleamine 2,3-Dioxygenase Activation and Neurodegeneration Induced by Corticosterone in the Hippocampus, In: Kenji Hashimoto, Chiba Daigaku, PLoS ONE. 2016.

LAM C.S., Pathophysiological role of monoamine oxidase-A in the activation of indoleamine-2,3-dioxygenase and neurodegeneration in the hippocampus induced by chronic intermittent hypoxia in rodents (PhD Thesis), The University of Hong Kong. 2017.

Lam C.S., LI J., Tipoe G.L., Youdim M.B.H. and Fung M.L., Monoamine oxidase A upregulated by chronic intermittent hypoxia activates indoleamine 2,3-dioxygenase and neurodegeneration, PLoS One . 2017, 12(6): e0177940.

Lam C.S., Tipoe G.L., Wong J.K.C. and Fung M.L., Neuroprotective effect of multifunctional drug M30 against depressive-like behavior induced by hypercortisolemia in rats. The 30^th World Congress of the International College of Neuropsychopharmacology. Seoul, International Journal of Neuropsychopharmacology. 2016, 19, Issue Suppl. (1): 47-48.

Researcher : LAM TF

List of Research Outputs

JIANG Y., LAM T.F., Ma C.W., Shum D.K.Y., WANG J.J. and Chan Y.S., Modulatory role of orexin on synaptic transmission in the central vestibular system, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

JIANG Y., LAM T.F., Ma C.W., Shum D.K.Y., Wang J.J. and Chan Y.S., Orexin regulates synaptic transmission within the rat vestibular nucleus, Abstracts of 12^th Int’l Symp. on Healthy Aging: Science and Aging – Wellness and Longevity: From Science to Service : 64. [HK. March 11-12, 2017]. 2017.

LAM T.F., Ma C.W., Shum D.K.Y., Wang J.J. and Chan Y.S., Behavioral expression of orexin-modulated transmission in the vestibular nucleus of postnatal rats, Neuroscience 2016 of the Society for the Neurosciences. 2016.

LAM T.F., Regulatory Role of Orexin on Postnatal Maturation of the Central Vestibular System in Rats (MPhil Thesis), The University of Hong Kong. 2017.

Researcher : LAM Y

List of Research Outputs

LAM Y., Chan W.C.W., Feng C., Chan B.P. and Chan D., Understanding the contribution of Lgr5+ interzone progenitor cells in articular cartilage development and regeneration, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : LAU CC

List of Research Outputs

LAU C.C., Functional characterization, clinical relevance and therapeutic implication of follistatin-like 1 (FSTL1) in esophageal squamous cell carcinoma (MPhil Thesis), The University of Hong Kong. 2016.

Researcher : LAU VM-Y

List of Research Outputs

ZHANG J., Jia L.J., Lin W., Yip Y.L., LAU V.M.-.Y., Zhu D., Tsang C.M., Zhou Y.L., Deng W., Lung H.L., Lung M.L., Cheung A. and Tsao G.S.W., Epstein-Barr Virus Encoded Latent Membrane Protein-1 Induces Glucose Transporter-1 Transcription is Dependent on the mTORC1 Mediated NF-κB Pathway Activation, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

ZHANG J., Jia L.J., Lin W., Yip Y.L., Lo K.W., LAU V.M.-.Y., Zhu D., Tsang C.M., Zhou Y., Deng W., Lung H.L., Lung M.L., Cheung L.M. and Tsao G.S.W., Epstein-barr Virus-encoded Latent Membrane Protein 1 Upregulates Glucose Transporter 1 Transcription Via The Mtorc1/nf-κb Signaling Pathways, Journal of Virology. 2017, 91: e02168-16.

Researcher : LEE SK

List of Research Outputs

LEE S.K., Characterization of Two-Pore Channel 2 by Nuclear Membrane Electrophysiology, PhD Thesis, The University of Hong Kong. 2016.

TONG C.K.B., LEE S.K., CHENG W.H., Lai K.O., Foskett J.K. and Cheung K.H., Familial Alzheimers disease-associated presenilin 1 mutants promote γ-secretase cleavage of STIM1 to impair store-operated Ca2+ entry, Science Signaling. 2016, 9: ra89.

Researcher : LI C

List of Research Outputs

LI C., LU Y.Y., YUE J. and Ballard H.J., Saikosaponin D, a novel autophagy inhibitor, potently inhibited Enterovirus 71(EV71)- induced cell death, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Li C. and Chan Y.S., Otolith-related neurons in vestibulo-olivary-cerebellar pathway of rats, Abstracts of 10^th FENS Forum of Neuroscience, 452. [Copenhagen, Denmark. July 2-6, 2016]. 2016.

Researcher : LI H

List of Research Outputs

LI H., Modulation of Extracellular and Intrinsic Pathways as Strategies to Promote Axonal Regeneration after Spinal Root Avulsion (PhD Thesis), The University of Hong Kong. 2017.

Researcher : LI J

List of Research Outputs

LI J., Development of a toolset for integrative analysis of high-throughput sequencing data and its application to primary ovarian insufficiency (PhD Thesis), The University of Hong Kong. 2017.

LI J., Norepinephrine Increases the Level of Monoammine Oxidase-A and Plays a Role in Intermittent Hypoxia Induced Injury in SH-SY5Y cells (MPhil Thesis), The University of Hong Kong. 2016.

Lam C.S., LI J., Tipoe G.L., Youdim M.B.H. and Fung M.L., Monoamine oxidase A upregulated by chronic intermittent hypoxia activates indoleamine 2,3-dioxygenase and neurodegeneration, PLoS One . 2017, 12(6): e0177940.

Li M., LI J., Li J., Pan Z., HSU S.J., Liu D., Zhan X., Wang J.J., Song Y. and Sham P.C., Robust and rapid algorithms facilitate large-scale whole genome sequencing downstream analysis in an integrative framework, Nucleic Acids Res. 2017, 45(9): e75.

Researcher : LI J

List of Research Outputs

LI J., Development of a toolset for integrative analysis of high-throughput sequencing data and its application to primary ovarian insufficiency (PhD Thesis), The University of Hong Kong. 2017.

LI J., Norepinephrine Increases the Level of Monoammine Oxidase-A and Plays a Role in Intermittent Hypoxia Induced Injury in SH-SY5Y cells (MPhil Thesis), The University of Hong Kong. 2016.

Researcher : LI L

List of Research Outputs

KHONG M.L., Li L. and Tanner J.A., Inorganic polyphosphate is a fundamental molecule in osteoblasts: from interactions to functions, 41st Annual Conference of the Malaysian Society for Biochemistry & Molecular Biology, Kuala Lumpur, Malaysia. 2016.

KHONG M.L., Li L., Lang C.Y.P. and Tanner J.A., Inorganic polyphosphate – a mediator of protein folding in osteoblasts via interaction with cyclophilin B, American Society for Biochemistry and Molecular Biology (ASBMB) Annual Meeting. 2017.

KHONG M.L., Li L., Lang C.Y.P. and Tanner J.A., Translating Polyphosphate-Cyclophilin B Interaction to an Understanding of Polyphosphate’s Role in Protein Folding, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

LI L., Yeung P.K.K. and Chung S.K., Dopamine Transporter (DAT)-expressing Cells Specific CR6-interacting Factor 1 (DATCrif1) Knockout Mice as an Experimental Animal Model for Study the Pathogenesis and Discovery of Novel Treatment of Parkinson’s Disease, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

Lang C.Y.P., KHONG M.L., Li L. and Tanner J.A., Elucidating human cyclophilin B properties as a polyphosphate-binding protein, National Collegiate Research Conference, Harvard University, Boston. 2017.

Lui E.L.H., AO K.L., Li L., KHONG M.L. and Tanner J.A., Inorganic polyphosphate triggers upregulation of interleukin 11 in human osteoblast-like SaOS-2 cells, Biochemical and Biophysical Research Communications. 2016, 479: 766-771.

Researcher : LI T

List of Research Outputs

LI T., Zheng F., Cheung M.C.H., WANG F. and Fu C., Fission yeast mitochondria are distributed by dynamic microtubules in a motor-independent manner, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : LI Z

List of Research Outputs

LI Z., Chan Y.S. and Shum D.K.Y., Activity regulated neuronal trafficking of heparanase 1, Abstracts of 12^th Int’l Symp. on Healthy Aging: Science and Aging – Wellness and Longevity: From Science to Service : 50. [HK. March 11-12, 2017]. 2017.

LI Z., LEUNG C., SIT H.M. and Sham M.H., Defective cell adhesion and cell migration in Sox10 mutant neural crest, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

LI Z., LEUNG C., SIT H.M. and Sham M.H., Dysregulation of cell adhesion and cell migration genes in Sox10 mutant neural crest, 18th International Congress of Developmental Biology. 2017.

LI Z., Chan Y.S. and Shum D.K.Y., Trafficking of Heparanase 1 is regulated by neuronal activity during homeostatic synaptic plasticity, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : LI Z

List of Research Outputs

LI Z., LEUNG C., SIT H.M. and Sham M.H., Dysregulation of cell adhesion and cell migration genes in Sox10 mutant neural crest, 18th International Congress of Developmental Biology. 2017.

Researcher : LIANG S

List of Research Outputs

Cheung Y.W., SHIU C.C., FRASER L.A., LIANG S., Dirkzwager R.M., Kinghorn A.B., TANG S.L.M. and Tanner J.A., Aptamer-mediated biosensing: from malaria diagnosis to DNA nanostructure dynamics, 5th International Conference on Bio-Sensing Technology. 2017.

Cheung Y.W., SHIU C.C., Wong W.C., TANG S.L.M., DIRKZWAGER R.M., LIANG S., KINGHORN A.B., FRASER L.A. and Tanner J.A., From DNA aptamer structure to splitting for use in DNA nanotweezers, Oligo 2017 Oxford: Antisense & Therapeutic Nucleic Acids. 2017.

KINGHORN A.B., DIRKZWAGER R.M., LIANG S., Cheung Y.W., FRASER L.A., SHIU C.C., TANG S.L.M. and Tanner J.A., Aptamer Affinity Maturation by Resampling and Microarray Selection, Analytical Chemistry. American Chemical Society, 2016, 88: 6981-6985.

SHIU C.C., Cheung Y.W., DIRKZWAGER R.M., LIANG S., Kinghorn A.B., FRASER L.A., TANG S.L.M. and Tanner J.A., A split aptamer can facilitate protein recognition in DNA nanotweezers, Aptamers 2017, 4th Oxford Symposium on Aptamers. 2017.

SHIU C.C., Cheung Y.W., LIANG S., Kinghorn A.B., LIANG S., TANG S.L.M. and Tanner J.A., An Aptamer-Mediated DNA Nano-Switch, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

SHIU C.C., Cheung Y.W., DIRKZWAGER R.M., LIANG S., Kinghorn A.B., FRASER L.A., TANG S.L.M. and Tanner J.A., Aptamer-Mediated Protein Molecular Recognition Driving a DNA Tweezer Nanomachine, Advanced Biosystems. 2017, 1: 1600006.

SHIU C.C., Cheung Y.W., Dirkzwager R.M., LIANG S., Kinghorn A.B., FRASER L.A., Tang S.L.M. and Tanner J.A., DNA Tweezer Nanomachine Mediated by Heterogeneous Recognition, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

SHIU C.C., TANG S.L.M., DIRKZWAGER R.M., LIANG S., Kinghorn A.B., Cheung Y.W., FRASER L.A., Godonoga M., Heddle J.G. and Tanner J.A., Protein driven aptamer toehold switches integrated into DNA origami nanostructures, Oligo 2017 Oxford: Antisense & Therapeutic Nucleic Acids. 2017.

Researcher : LIANG Y

List of Research Outputs

Wong Y.M.E., LIANG Y., LIU Y. and Sham M.H., The roles of Hedgehog receptors Cdo and Boc in controlling cochlear hair cell formation, Gordon Research Conference: Auditory System 2016.

Researcher : LIN L

List of Research Outputs

LIN L., LO H.Y.L., Lyu Q. and Lai K.O., Determination of dendritic spine morphology by the striatin scaffold protein STRN4 through interaction with the phosphatase PP2A, Journal of Biological Chemistry. 2017, 292: 9451-9464.

LIN L., LYU Q., Fei E., Ip N.Y. and Lai K.O., The epilepsy and intellectual disability-related gene tbc1d24 encodes a novel synaptic protein that regulates dendritic spine morphogenesis in neuron, 12th International Symposium on Healthy Aging. 2017.

LO H.Y.L., LIN L., Lyu Q. and Lai K.O., A Potential Role of NMDA Receptor-dependent Expression of Striatin-4 in Dendritic Spine Maturation, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

LO H.Y.L., LIN L., Lyu Q. and Lai K.O., Determination of dendritic spine morphology by the striatin scaffold protein STRN4 through interaction with the phosphatase PP2A, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : LIN Q

List of Research Outputs

Li C., Yu B., Shi L., Geng W., Lin Q., Ling C., Yang M., Ng K.T.P., Huang J. and Man K., 'Obligate' anaerobic Salmonella strain YB1 suppresses liver tumor growth and metastasis in nude mice, Oncology Letters. 2016, 13(1): 177-183.

XU C., LIN Q., DENG J., Yu B., ARYA S. and Huang J., Live attenuated Salmonella-based Vaccines delivering SaEsxA by Type III Secretion System Confer Protection against Staphylococcus aureus Infection, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : LIN W

List of Research Outputs

CHAN M.H.M., Lau K.L.K., Lin W., Tsao G.S.W. and Tsang C.M., The interaction of berberine with chemodrugs on Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Jia L.J., ZHANG J., Yip Y.L., Lin W., Jin D., Tsang C.M. and Tsao G.S.W., Hypoxia induces lytic reactivation of Epstein-Barr virus in stable M81-infected nasopharyngeal epithelial cells, Keystone Symposia Conference on Tumor Metabolism: Mechanisms and Targets. 2017.

LIN W., Establishment and characterization of patient-derived xenografts and cell lines from nasopharyngeal carcinoma (PhD Thesis), The University of Hong Kong. 2017.

Tsao G.S.W., ZHANG J., Jia L.J., Tsang C.M., Lin W., Yip Y.L., Deng W., Lo K.W. and Lung M.L., The role of EBV infection in aerobic glycolysis in nasopharyngeal carcinoma., AACR Annual Meeting 2017.

ZHANG J., Jia L.J., Lin W., Yip Y.L., LAU V.M.-.Y., Zhu D., Tsang C.M., Zhou Y.L., Deng W., Lung H.L., Lung M.L., Cheung A. and Tsao G.S.W., Epstein-Barr Virus Encoded Latent Membrane Protein-1 Induces Glucose Transporter-1 Transcription is Dependent on the mTORC1 Mediated NF-κB Pathway Activation, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

ZHANG J., Jia L.J., Lin W., Yip Y.L., Lo K.W., LAU V.M.-.Y., Zhu D., Tsang C.M., Zhou Y., Deng W., Lung H.L., Lung M.L., Cheung L.M. and Tsao G.S.W., Epstein-barr Virus-encoded Latent Membrane Protein 1 Upregulates Glucose Transporter 1 Transcription Via The Mtorc1/nf-κb Signaling Pathways, Journal of Virology. 2017, 91: e02168-16.

Researcher : LIU KL

List of Research Outputs

Gentleman S., Goldfinger M.E.D., Chang R.C.C., Lai H.M. and LIU K.L., Next generation histology pipeline for three-dimensional visualization of archival chronic traumatic encephalopathy brain tissues, The 13th International Conference on Alzheimer’s & Parkinson’s Diseases 2017, Section B01.a Disease mechanisms, pathophysiology: tau aggregation, phosphorylation, acetylation & modifications. . 2017, 128.

LIU K.L., Lai H.M., Chang R.C.C. and Gentleman S.M., Free-of-acrylamide SDS-based Tissue Clearing (FASTClear): A novel protocol of tissue clearing for three-dimensional visualisation of human brain tissues., Neuropathol. Appl. Neurobiol.,. 2017, 43: 346-351.

Researcher : LIU L

List of Research Outputs

LIU L., Development of tunable synthetic circuits for precise control of gene expression in mammalian cells (PhD Thesis), The University of Hong Kong. 2016.

Liu L., Huang W. and Huang J., Synthetic circuits that process multiple light and chemical signal inputs, BMC Systems Biology. 2017, 11(1): 5-14.

Researcher : LIU Y

List of Research Outputs

HO C.C., QIN T., Wang B., Wong Y.M.E., LIU Y., Hui C.C. and Sham M.H., Sufu controls the proliferation and differentiation of cochlear prosensory progenitors, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

HO C.C., QIN T., Wang B., Wong Y.M.E., LIU Y., Hui C.C. and Sham M.H., Sufu regulates the proliferation and differentiation of hair cell progenitors in mammalian cochlea, 18th International Congress of Developmental Biology. 2017.

LIU Y., Wang B., Wong Y.M.E., Tsang S.L., HO C.C., Hui C.C. and Sham M.H., The roles of Irx3 and Irx5 in inner ear neurosensory patterning, 18th International Congress of Developmental Biology. 2017.

LIU Y., Wang B., Wong Y.M.E., Tsang S.L., HO C.C., Hui C.C. and Sham M.H., The roles of Irx3 and Irx5 in inner ear neurosensory patterning, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Wong Y.M.E., LIANG Y., LIU Y. and Sham M.H., The roles of Hedgehog receptors Cdo and Boc in controlling cochlear hair cell formation, Gordon Research Conference: Auditory System 2016.

Researcher : LO HYL

List of Research Outputs

LIN L., LO H.Y.L., Lyu Q. and Lai K.O., Determination of dendritic spine morphology by the striatin scaffold protein STRN4 through interaction with the phosphatase PP2A, Journal of Biological Chemistry. 2017, 292: 9451-9464.

LO H.Y.L., LIN L., Lyu Q. and Lai K.O., A Potential Role of NMDA Receptor-dependent Expression of Striatin-4 in Dendritic Spine Maturation, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

LO H.Y.L., LIN L., Lyu Q. and Lai K.O., Determination of dendritic spine morphology by the striatin scaffold protein STRN4 through interaction with the phosphatase PP2A, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : LONG F

List of Research Outputs

LONG F., Osorio Da Silva L.A., WU X. and Zhou Z., ISM1 in mammary gland morphogenesis and its malignant transformation, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : LUI WY

List of Research Outputs

Yuen K.S., Wang Z.M., WONG N.H.M., Zhang Z.Q., CHENG T.F., LUI W.Y., Chan C.P. and Jin D., Suppression of Epstein-Barr virus DNA load in latently infected nasopharyngeal carcinoma cells by CRISPR/Cas9, Virus Res.. 2017.

Researcher : LUK TCS

List of Research Outputs

LUK T.C.S., Tong M., Ng K.Y., Guan X. and Ma S.K.Y., Identification of REX1 as a Regulator of Cancer Stemness in CD133+ Liver Cancer Stem Cells by Genome-wide DNA Methylation Analysis, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

Researcher : LYU Q

List of Research Outputs

LIN L., LO H.Y.L., Lyu Q. and Lai K.O., Determination of dendritic spine morphology by the striatin scaffold protein STRN4 through interaction with the phosphatase PP2A, Journal of Biological Chemistry. 2017, 292: 9451-9464.

LIN L., LYU Q., Fei E., Ip N.Y. and Lai K.O., The epilepsy and intellectual disability-related gene tbc1d24 encodes a novel synaptic protein that regulates dendritic spine morphogenesis in neuron, 12th International Symposium on Healthy Aging. 2017.

LO H.Y.L., LIN L., Lyu Q. and Lai K.O., A Potential Role of NMDA Receptor-dependent Expression of Striatin-4 in Dendritic Spine Maturation, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

LO H.Y.L., LIN L., Lyu Q. and Lai K.O., Determination of dendritic spine morphology by the striatin scaffold protein STRN4 through interaction with the phosphatase PP2A, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : Lai KO

Project Title:	Investigating the functional role of a novel synaptic protein TBC1D24 in activity-dependent spine morphogenesis
Investigator(s):	Lai KO
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2014

Project Title:	Investigating the regulatory role of protein arginine methylation in dendritic spine development
Investigator(s):	Lai KO
Department:	School of Biomedical Sciences
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	01/2016

Project Title:	Investigating the function of protein arginine methyltransferase PRMT5 in neuron: regulatory role in mRNA tranpsort and dendritic spine maturation
Investigator(s):	Lai KO
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2016

Project Title:	Cell Biology of the Neuron; A potential role of NMDA receptor-dependent expression of Striatin-4 in dendritic spine development
Investigator(s):	Lai KO
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2016
Completion Date:	07/2016

Project Title:	Investigating the role of the kinesin motor KIF5B in dendritic mRNA trafficking in neurons
Investigator(s):	Lai KO, Huang J
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2017

Project Title:	Investigation of protein localization and transport dynamics in human neuron by genome editing
Investigator(s):	Lai KO, Shum DKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2017

Project Title:	Cellular Mechanisms of Synaptic Functions and Plasticity in Health and Neurodegenerative Diseases
Investigator(s):	Lai KO
Department:	School of Biomedical Sciences
Source(s) of Funding:	Areas of Excellence Scheme
Start Date:	06/2017

List of Research Outputs

CHAN H.L., Huang J. and Lai K.O., The Kinesin Motor Protein KIF5B Regulates RNA Trafficking and Dendritic Spine Morphogenesis in Hippocampal Neuron, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

CHAN H.L., Huang J. and Lai K.O., To elucidate the role of the Kinesin motor protein KIF5B in mRNA transport and dendritic spine morphogenesis, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

LIN L., LO H.Y.L., Lyu Q. and Lai K.O., Determination of dendritic spine morphology by the striatin scaffold protein STRN4 through interaction with the phosphatase PP2A, Journal of Biological Chemistry. 2017, 292: 9451-9464.

LIN L., LYU Q., Fei E., Ip N.Y. and Lai K.O., The epilepsy and intellectual disability-related gene tbc1d24 encodes a novel synaptic protein that regulates dendritic spine morphogenesis in neuron, 12th International Symposium on Healthy Aging. 2017.

LO H.Y.L., LIN L., Lyu Q. and Lai K.O., A Potential Role of NMDA Receptor-dependent Expression of Striatin-4 in Dendritic Spine Maturation, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

LO H.Y.L., LIN L., Lyu Q. and Lai K.O., Determination of dendritic spine morphology by the striatin scaffold protein STRN4 through interaction with the phosphatase PP2A, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Lai K.O., Molecular determinants of synapse development: focus on dendritic mRNAs, The 4th International Anatomical Sciences and Cell Biology Conference. 2016.

Lai K.O., The use of human stem cell-derived neurons to study neurodevelopmental disorders, 12th International Symposium on Healthy Aging. 2017.

Liang Z., Zhan Y., Shen Y., Wong C.C.L., Yates J.R. .3.R.D., Plattner F., Lai K.O. and Ip N.Y., The pseudokinase CaMKv is required for the activity-dependent maintenance of dendritic spines, Nature Communications. 2016, 7: 13282.

TONG C.K.B., LEE S.K., CHENG W.H., Lai K.O., Foskett J.K. and Cheung K.H., Familial Alzheimers disease-associated presenilin 1 mutants promote γ-secretase cleavage of STIM1 to impair store-operated Ca2+ entry, Science Signaling. 2016, 9: ra89.

Researcher : Lai SWC

Project Title:	The role of sleep on fear learning and experience-dependent dendritic spine plasticity
Investigator(s):	Lai SWC
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	07/2014
Completion Date:	07/2016

Project Title:	Mechanism of fear associative learning in the frontal association cortex and its implications in schizophrenia
Investigator(s):	Lai SWC
Department:	School of Biomedical Sciences
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	10/2015

Project Title:	The role of sleep on fear learning and dendritic spine plasticity
Investigator(s):	Lai SWC, Cheung WH
Department:	School of Biomedical Sciences
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2016

Project Title:	Cue-specific dendritic spine plasticity of fear conditioning and extinction in the mouse auditory cortex
Investigator(s):	Lai SWC
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2016

Project Title:	Mechanisms underlying the antidepressant effects of ketamine in an animal model of depression: the role of dendritic spines and interneurons
Investigator(s):	Lai SWC, Chang RCC, Lai KO
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2016

Project Title:	Annual meeting of Society for Neuroscience 2016; Effects of ketamine on dendritic spine plasticity in animal depression model
Investigator(s):	Lai SWC
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2016
Completion Date:	11/2016

Project Title:	Reversible microcircuitry of fear learning and unlearning in the mouse auditory cortex
Investigator(s):	Lai SWC, Chan YS
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2017

Project Title:	Advanced optogenetics and functional calcium imaging platform for deep brain structures in awake, free-moving, and behaving animals in learning and memory
Investigator(s):	Lai SWC, Chan YS, Chang RCC, Chan SY, Cheung MCH, Lai KO, Lo ACY, Lee CW, Lim LW, Shum DKY, Wu W
Department:	School of Biomedical Sciences
Source(s) of Funding:	Small Equipment Grant
Start Date:	06/2017

Project Title:	The role of KIF5B in learning and memory
Investigator(s):	Lai SWC, Huang J, Lai KO
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

List of Research Outputs

Chen K., Zhang L., Tan M., Lai S.W.C., Li A., Ren C. and So K.F., Treadmill exercise suppressed stress-induced dendritic spine elimination in mouse barrel cortex and improved working memory via BDNF/TrkB pathway, Translational Psychiatry. 2017, 7: e1069.

HUANG Y. and Lai S.W.C., Altered Synaptic Plasticity in a Mouse Schizophrenia Model, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

YOU R., Ho Y.S., Hung H.L.C., Lai S.W.C. and Chang R.C.C., Investigating the effects of slicia nanoparticles as affective and cognitive behaviors. , The 12th International Symposium on Healthy Aging. 2017, 50.

Researcher : Lai WL

List of Research Outputs

Xu H.T., Lai W.L., Liu H.F., Wong L.L.Y., Ng I.O.L. and Ching Y.P., PAK4 phosphorylates p53 at serine 215 to promote liver cancer metastasis., Cancer Research. American Association for Cancer Research., 2016, 76: 5732-5742.

Researcher : Lam CS

List of Research Outputs

Researcher : Lam TFU

List of Research Outputs

JIANG Y., Lam T.F.U., Ma C.W., Shum D.K.Y., Wang J.J. and Chan Y.S., Modulatory role of orexin on synaptic transmission in the central vestibular system, Soc. Neuroscience Abstract (USA), 803.04 [San Diego. Nov. 12-16, 2016]. 2016.

Lam T.F.U., Ma C.W., Shum D.K.Y., Wang J.J. and Chan Y.S., Behavioral expression of orexin-modulated transmission in the vestibular nucleus of postnatal rats, Soc. Neuroscience Abstract (USA), 803.09 [San Diego. Nov. 12-16, 2016]. 2016.

Researcher : Lam WH

List of Research Outputs

Sze K.H., Lam W.H., Zhang H., Ke Y., Tse M.K., Woo P.C.Y., Lau S.K.P., Lau C.Y., Cai J., Tung E.T., Lo R.K., Xu S., Kao R.Y.T., Hao Q. and Yuen K.Y., Talaromyces marneffei Mp1p Is a Virulence Factor that Binds and Sequesters a Key Proinflammatory Lipid to Dampen Host Innate Immune Response, Cell Chemical Biology. 2017, 24: 182-194.

Woo P.C.Y., Lau S.K.P., Lau C.Y., Tung T.K., Chong T.K., Yang F., Zhang H., Lo K.C., Cai J., Au Yeung K.H.R., Ng W.F., Tse H., Wong S.S.Y., Xu S., Lam W.H., Tse M.K., Sze K.H., Kao R.Y.T., Reiner N.E., Hao Q. and Yuen K.Y., Mp1p Is a Virulence Factor in Talaromyces (Penicillium) marneffei, PLOS Neglected Tropical Diseases. 2016, 10: e0004907.

Researcher : Lam YM

Project Title:	American Association for Cancer Research Annual Meeting 2017; Tumor suppressive role of BMI-1 through inhibition of JAK-STAT signaling in leukemia
Investigator(s):	Lam YM
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2017
Completion Date:	04/2017

List of Research Outputs

Lam Y.M., Chan Y.F., Chan L.C. and Ng R.K., Histone deacetylase inhibitors induce leukemia gene expression in cord blood hematopoietic stem cells expanded ex vivo, International journal of hematology. 2017, 105: 37-43.

Lam Y.M., LAM S.Y., Leung A.Y.H. and Ng R.K., Tumor suppressive role of BMI-1 through inhibition of JAK-STAT signaling in leukemia, American Association for Cancer Research (AACR) Annual Meeting April 1-5,2017, Washington DC, USA. 2017.

Ng R.K., YANG X. and Lam Y.M., Dysregulation of DNA methylation at gene regulatory regions in MLL-rearranged leukemia, Epigenomics of Common Diseases November 1-4, 2016, Cambridge, UK. 2016.

YANG X., Lam Y.M., Lui W.C. and Ng R.K., Epigenetic dysregulation of transcriptional program in MLL-EEN leukemia, American Association for Cancer Research (AACR) Annual Meeting April 1-5,2017, Washington DC, USA. 2017.

Researcher : Lau CYW

Project Title:	Structural role of the BRCA1-PALB2-BRCA2 complex in DNA repair
Investigator(s):	Lau CYW
Department:	School of Biomedical Sciences
Source(s) of Funding:	AXA Research Fund
Start Date:	08/2014

Project Title:	Structural Role of the BRCA1-PALB2-BRCA2 Complex in DNA Repair
Investigator(s):	Lau CYW, Huen MSY
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	02/2015
Completion Date:	07/2016

Researcher : Lau KLK

List of Research Outputs

CHAN M.H.M., Lau K.L.K., Lin W., Tsao G.S.W. and Tsang C.M., The interaction of berberine with chemodrugs on Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : Lau PY

List of Research Outputs

Li S.K., Tang H.C., Lau P.Y., Zhou Y. and Ching Y.P., HBx oncoprotein induces chromosome instability in hepatocarcinogenesis via dysregulation of putative tumor suppressor, TAX1BP2, Health Research Symposium 2017.

Researcher : Lee CW

Project Title:	Live imaging of acetylcholine receptor trafficking at developing neuromuscular junctions
Investigator(s):	Lee CW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2016

Project Title:	Spatiotemporal regulation of actin monomers for promoting membrane protrusions in axonal growth, guidance and regeneration
Investigator(s):	Lee CW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	01/2017

Project Title:	Investigating the pathogenic mechanisms underlying ocular and generalized myasthenia gravis using Xenopus cell-based assay
Investigator(s):	Lee CW, Chan KH
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2017

Project Title:	Cellular Dynamics & Models; The formation and dynamic reorganization of aneural acetylcholine receptor clusters for the assembly of synaptic specializations at developing neuromuscular junctions
Investigator(s):	Lee CW
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2017
Completion Date:	04/2017

Project Title:	Investigating the effects of ALS-linked mutations in Profilin on neuronal actin dynamics using an in vitro ALS model
Investigator(s):	Lee CW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

Researcher : Lee K

List of Research Outputs

PANG C.C.C., Man S.C., Lee K., Noble W. and Chang R.C.C., Establishing a pre-clinical therapeutic platform to screen for dementia therapeutics. , International Alzheimer’s Disease Conference 2017. 41.

Researcher : Leung KKH

List of Research Outputs

Cheah K.S.E., Leung K.K.H., Tam A., Kwong M., Pelling A., Jahan I. and Lovell-Badge R.H., Impact of Sox2 dosage on sensory neurogenesis and prosensory versus non-sensory cell fate in the inner ear., Gordon Research Conference - 2017 Neural Crest & Cranial Placodes, Ventura, USA. February 5-10, 2017. . 2017.

Researcher : Li B

List of Research Outputs

Cheung A., Li B., Xu W., Liu J. and Chan K.W., miR-29c modulates chemoresistance in esophageal cancer cells by suppressing FBXO31, European Journal of Cancer (24th Biennial Congress of the European Association for Cancer Research). 2016, 61 Suppl 1: S64.

Fung T.M., Ng K.Y., Tong M., CHEN J., Chai S., Chan K.T., Law S.Y.K., Lee N.P.Y., Choi M.Y., Li B., Cheung A., Tsao G.S.W., Qin Y.R., Guan X., Chan K.W. and Ma S.K.Y., Neuropilin-2 promotes tumourigenicity and metastasis in oesophageal squamous cell carcinoma through ERK-MAPK-ETV4-MMP-E-cadherin deregulation, Journal of Pathology. 2016, 239(3): 309-319.

Li B., XU W., Lam A.K.Y., Wang Y.A.N.G., Hu H.-.F., Guan X., Qin Y.R., Saremi N., Tsao G.S.W., He Q.-.Y. and Cheung A., Significance of PI3K/AKT signaling pathway in metastasis of esophageal squamous cell carcinoma and its potential as a target for anti-metastasis therapy, Oncotarget. 2017, 8: 38755-38766.

XU W., Li B., Guan X., Chung S.K., Yang W., Yip Y.L., Law S.Y.K., Chan K.T., Lee N.P.Y., Chan K.W., Xu L.Y., Li E.M., Tsao G.S.W., He Q.Y. and Cheung A., Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression, Nature Communications. 2017, 8: 14399.

Researcher : Li C

List of Research Outputs

Li C. and Chan Y.S., Otolith-related neurons in vestibulo-olivary-cerebellar pathway of rats, Abstracts of 10^th FENS Forum of Neuroscience, 452. [Copenhagen, Denmark. July 2-6, 2016]. 2016.

Researcher : Li L

List of Research Outputs

Researcher : Li NF

List of Research Outputs

XU W., Li N.F. and Chen J., Effects of the Apical Krebs Solution on Ion Transport of Cultured Pig Tracheal Epithelia, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

XU W., Li N.F. and Chen J., Sodium in The Apical Solution Mediates Downregulation of Ion Transport in Cultured Pig Tracheal Epithelia, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : Li RA

Project Title:	Cell-based Heart Regeneration
Investigator(s):	Li RA, Boheler KR, Chan BP, Chan CWY, Chan GCF, Chien KR, Lee HC, Yue J, Ng RK, Ngan AHW
Department:	Medicine
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	09/2011
Completion Date:	09/2017

Project Title:	Stem Cell and Regenerative Medicine
Investigator(s):	Li RA, Chan GCF, Tse HF
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	06/2013

Project Title:	Establishing a Molecular Encyclopedia for Stem Cell & Regenerative Medicine: Heart
Investigator(s):	Li RA, Tam PKH, Cheung YF
Department:	Dr. Li Dak-Sum Research Centre
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 2)
Start Date:	08/2016

List of Research Outputs

ZHANG W., Kong M.C.W., TONG M., TONG M., HUANG N., Li R.A. and Chan B.P., Maturation of human embryonic stem cell-derived cardiomyocytes (hESC-CMs) in 3D collagen matrix: Effects of niche cell supplementation and mechanical stimulation, Acta Biomaterialia. 2017, 49: 204-217.

Researcher : Li S

List of Research Outputs

Keung W.W.Y., Ren L., Li S., Wong A.O., Chopra A., Kong M.C.W., Tomaselli G.F., Chen C.S. and Li R.A., Non-cell autonomous cues for enhanced functionality of human embryonic stem cell-derived cardiomyocytes via maturation of sarcolemmal and mitochondrial KATP channels, Scientific Reports. 2016, 6: 34154.

Researcher : Li SK

Project Title:	A Study of the Roles of Hepatitis B Virus X Protein on the Transcriptional Regulation of Tumor Suppressor TAX1BP2 in Hepatocellular Carcinoma
Investigator(s):	Li SK, Ching YP
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	08/2016

List of Research Outputs

Li S.K., Tang H.C., Lau P.Y., Zhou Y. and Ching Y.P., HBx oncoprotein induces chromosome instability in hepatocarcinogenesis via dysregulation of putative tumor suppressor, TAX1BP2, Health Research Symposium 2017.

Researcher : Liang R

List of Research Outputs

YANG X., Cheung M.P.L., Liang R. and Cheung M.C.H., Elucidating the role of DLC1 in Metastatic Melanoma, 4th International Anatomical Sciences & Cell Biology Conference. 2016.

Researcher : Lim LW

Project Title:	Comparative study of potential brain target stimulation for cognitive improvement in aged animal model
Investigator(s):	Lim LW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2016

Project Title:	Memory and cognitive enhancement by electrical stimulation in experimental animal models of dementia: In search of brain targets and mechanisms
Investigator(s):	Lim LW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	10/2016

Project Title:	International Conference on Aging and Disease-2016 (ICAD-2016), October 1-2, Stanford University, California, United States.; Ventromedial prefrontal cortex stimulation in the aged brain enhances memory and neurogenesis
Investigator(s):	Lim LW
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/2016
Completion Date:	10/2016

Project Title:	Hippocampal gene expression profiling after deep brain stimulation in aged animal model of cognitive impairment
Investigator(s):	Lim LW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	02/2017

List of Research Outputs

Heng B.C.A., GONG T., Wang S., Lim L.W., Wu W. and Zhang C., Decellularized Matrix Derived from Neural Differentiation of Embryonic Stem Cells Enhances the Neurogenic Potential of Dental Follicle Stem Cells, Journal of Endodontics. 2017, 43(3): 409-416.

Huguet G., Kadar E., Temel Y. and Lim L.W., Electrical stimulation normalizes c-Fos expression in the deep cerebellar nuclei of depressive-like rats: Implication of antidepressant activity. , The Cerebellum. 2017, 16(2): 398-410.

Lim L.W., Brain pacemaker and memory enhancement: Investigations of neural and molecular mechanisms in the aged brain. (Invited Symposium Speaker), Neurocon 2017 - "Growth, Senescence and Mortality of Neurons: From Traditional Medicine to Cutting Edge Technology", Kolkata, India.. 2017.

Lim L.W., Brain pacemaker and memory enhancement: Investigations of neural and molecular mechanisms in the aged brain, Neurocon 2017 - "Growth, Senescence and Mortality of Neurons: From Traditional Medicine to Cutting Edge Technology", Kolkata, India.. 2017.

Lim L.W., Brain pacemaker in prefrontal cortex: from functional neurocircuitry modulation to behavioral regulation in neurological and psychiatric disorders. (Young Investigator Award Speaker), The 14th Annual Meeting of Asian-Pacific Society for Neurochemistry, Kuala Lumpur, Malaysia. . 2016.

Lim L.W., Brain pacemaker in prefrontal cortex: from functional neurocircuitry modulation to behavioral regulation in neurological and psychiatric disorders., 14th Meeting of the Asian-Pacific Society for Neurochemistry, Malaysia.. Frontiers in Cellular Neuroscience, 2016.

Lim L.W., Deep brain stimulation induces changes from behavioral response to molecular signaling. (Honorary Lecturer), Asia-Pacific Winter School on Bio-Inspired Systems and Prosthetic Devices (BioPRO) 2016, Universiti Teknologi Petronas, Malaysia.. 2016.

Lim L.W., Deep brain stimulation induces changes from behavioral response to molecular signaling, Asia-Pacific Winter School on Bio-Inspired Systems and Prosthetic Devices (BioPRO) 2016, Universiti Teknologi Petronas, Malaysia.. 2016.

Lim L.W., Electrical stimulation enhances mood and memory functions in animal models , The 4th International Anatomical Sciences & Cell Biology Conference, Hong Kong. . 2016.

Lim L.W., Electrical stimulation enhances mood and memory functions in animal models. (Invited Symposium Speaker), The 4th International Anatomical Sciences & Cell Biology Conference, Hong Kong.. 2016.

Lim L.W., Electrical stimulation enhances mood and memory functions in animal models, The 41st Annual Conference of the Malaysian Society for Biochemistry and Molecular Biology, Kuala Lumpur, Malaysia. . 2016.

Lim L.W., National Young Scientist Award Finalist , Ministry of Science, Technology and Innovation, Malaysia.. 2016.

Lim L.W., Prefrontal cortex stimulation induces changes from molecule to behavior. (Keynote Speaker), The 41st Annual Conference of the Malaysian Society for Biochemistry and Molecular Biology, Kuala Lumpur, Malaysia. . 2016.

Lim L.W., Shrestha S., Or Y.Z., TAN Z.K.S., Chung H.H., Sun Y.A.N.G., Lim C.H.E.W. .L.E.N.G., MUHAMMAD SHARAFUDDIN BIN M.K., Lufkin T. and Lin V.C.L., Tetratricopeptide repeat domain 9A modulates anxiety-like behavior in female mice , Scientific Reports. 2016, 37568.

Lim L.W., Ventromedial prefrontal cortex stimulation in the aged brain enhances memory and neurogenesis. (Invited Guest Speaker), The International Conference on Aging and Disease-2016, Stanford University, USA.. 2016.

Lim L.W., Ventromedial prefrontal cortex stimulation in the aged brain enhances memory and neurogenesis, The International Conference on Aging and Disease-2016, Stanford University, USA.. 2016.

Lim L.W., Young Investigator Award, Asian-Pacific Society for Neurochemistry. 2016.

Lim W.L., Temel Y., Fung W.W.L., Steinbusch H. and Lim L.W., Electrical stimulation rescues dopaminergic neurodegeneration in the dorsal raphe nucleus of vulnerable depressive-like rats. , 50th Malaysia-Singapore Congress of Medicine & the 3rd Academy of Medicine Malaysia-Academy of Medicine Singapore-Hong Kong Academy of Medicine Tripartite Congress incorporating the 1st Emergency Medicine Annual Scientific Meeting. Malaysia.. Malaysian Journal of Emergency Medicine., 2016.

MUHAMMAD SHARAFUDDIN BIN M.K., Lim W.L., Fung W.W.L., Temel Y. and Lim L.W., Electrical stimulation rescues dopaminergic degeneration in the dorsal raphe nucleus and enhanced hippocampal neurogenesis of vulnerable depressive-like rats., 14th Meeting of the Asian-Pacific Society for Neurochemistry, Malaysia.. Frontiers in Cellular Neuroscience, 2016.

MUHAMMAD SHARAFUDDIN BIN M.K., Lim W.L., Temel Y. and Lim L.W., Electrical stimulation rescues dopaminergic neurodegeneration in the dorsal raphe nucleus of vulnerable depressive-like rats, 4th International Anatomical Sciences & Cell Biology Conference, Hong Kong.. 2016.

MUHAMMAD SHARAFUDDIN BIN M.K., Lim W.L., Fung W.L., Temel Y. and Lim L.W., Travel Fellowship Award, Asian-Pacific Society for Neurochemistry . 2016.

TAN Z.K.S. and Lim L.W., Brain pacemaker and memory enhancement: Investigation of neural and molecular mechanisms in the aged brain. , 50th Malaysia-Singapore Congress of Medicine & the 3rd Academy of Medicine Malaysia-Academy of Medicine Singapore-Hong Kong Academy of Medicine Tripartite Congress incorporating the 1st Emergency Medicine Annual Scientific Meeting. Malaysia.. Malaysian Journal of Emergency Medicine., 2016.

TAN Z.K.S., MUHAMMAD SHARAFUDDIN BIN M.K., Hescham S., Blokland A., Temel Y. and Lim L.W., Deep brain stimulation of the entorhinal cortex or perifornical area in an aged animal model transiently restores memory function., The Francis Crick Symposium, Suzhou, China. 2017.

TAN Z.K.S., Lim L.W., Shrestha S., OR Y.Z., Chung H.H., Sun Y., Lim C.L., MUHAMMAD SHARAFUDDIN BIN M.K., Lufkin T. and Lin V.C.L., Tetratricopeptide repeat domain 9A modulates anxiety-like behavior in female mice, 4th International Anatomical Sciences & Cell Biology Conference, Hong Kong.. 2016.

Researcher : Lin B

Project Title:	Modulation of the PTEN/mTOR pathway enhances the survival of cone photoreceptors in retinal degeneration disorders
Investigator(s):	Lin B, Ching YP
Department:	Anatomy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	12/2013
Completion Date:	07/2016

Project Title:	Ectopic expression of the light-sensitive protein melanopsin in rod photoreceptors prevents retinal degeneration
Investigator(s):	Lin B
Department:	Anatomy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015
Completion Date:	07/2016

Project Title:	Cyclooxygenase-1 deletion promotes microglia quiescence and enhances cone photoreceptor survival in retinal degeneration disorders
Investigator(s):	Lin B, Ching YP
Department:	Anatomy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2015
Completion Date:	07/2016

Project Title:	Inhibition of colony-stimulating factor 1 receptor signaling in microglia delays the progression of the chronic neurodegeneration in retinitis pigmentosa
Investigator(s):	Lin B
Department:	Anatomy
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2015
Completion Date:	07/2016

Project Title:	Inhibition of colony-stimulating factor 1 receptor (CSF1R) signaling in microglia delays the progression of the chronic neurodegeneration in retinitis pigmentosa
Investigator(s):	Lin B
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016
Completion Date:	07/2016

Project Title:	annual meeting of the association for research in vision and ophthalmology ; PTEN deletion enhances the survival of cone photoreceptors in retinal degeneration disorders
Investigator(s):	Lin B
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2016

List of Research Outputs

XIONG G., Chen S. and Lin B., Prolong the Survival of Photoreceptors by Modulating the Apoptosis Pathway in a Mouse Model of Retinitis Pigmentosa, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

Researcher : Lin Q

List of Research Outputs

Researcher : Lin W

List of Research Outputs

LIN W., Establishment and characterization of patient-derived xenografts and cell lines from nasopharyngeal carcinoma (PhD Thesis), The University of Hong Kong. 2017.

Researcher : Liu AJ

Project Title:	Neural Crest & Cranial Placodes Gordon Research Conference ; Asymmetric localization of Dlc1 defines neural crest polarity for directional delamination and migration
Investigator(s):	Liu AJ
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	02/2017
Completion Date:	02/2017

List of Research Outputs

Liu A.J. and Cheung M.C.H., Neural crest stem cells and their potential therapeutic applications, Developmental Biology. 2016, 419: 199-216.

RAO Y., Liu A.J., Cheung M.P.L. and Cheung M.C.H., Dlc1, a Rho GTPase-activating protein, is essential for cranial neural crest development, 4th International Anatomical Sciences & Cell Biology Conference. 2016.

Researcher : Liu B

Project Title:	Adult stem cell decline accelerates premature ageing in Zmpste24 deficient mice
Investigator(s):	Liu B, Zhou Z
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	08/2008

Project Title:	Stem Cells 2009 Oxidative stress-mediated accelerated adult stem cell decline contributes to premature ageing in Zmpste24–/– mice
Investigator(s):	Liu B
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2009

Project Title:	Quantitative mass spectrometry-based screening for SIRT1 deacetylating targets
Investigator(s):	Liu B, Zhou Z, Chu IK
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2012

Project Title:	Role of Autophagy in Cellular Senescence and Laminopathy-based Premature Ageing
Investigator(s):	Liu B
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2013

Researcher : Liu L

List of Research Outputs

LIU L., Development of tunable synthetic circuits for precise control of gene expression in mammalian cells (PhD Thesis), The University of Hong Kong. 2016.

Liu L., Huang W. and Huang J., Synthetic circuits that process multiple light and chemical signal inputs, BMC Systems Biology. 2017, 11(1): 5-14.

Researcher : Liu VWS

List of Research Outputs

Liu V.W.S., Yao W.L., Tam C.W., Yao K.M. and Shiu S.Y.W., Melatonin Inhibits Androgen Receptor Splice Variant-7 (AR-V7)-Induced Nuclear Factor-Kappa B (NF-κB) Activation and NF-κB Activator-Induced AR-V7 Expression in Prostate Cancer Cells: Potential Implications for the Use of Melatonin in Castration-Resistant Prostate Cancer (CRPC) Therapy., Int. J. Mol. Sci.. 2017, 18(6): pii: E1130.

Researcher : Lovell-Badge RH

List of Research Outputs

Cheah K.S.E., Leung K.K.H., Tam A., Kwong M., Pelling A., Jahan I. and Lovell-Badge R.H., Impact of Sox2 dosage on sensory neurogenesis and prosensory versus non-sensory cell fate in the inner ear., Gordon Research Conference - 2017 Neural Crest & Cranial Placodes, Ventura, USA. February 5-10, 2017. . 2017.

Researcher : Lui WC

List of Research Outputs

YANG X., Lam Y.M., Lui W.C. and Ng R.K., Epigenetic dysregulation of transcriptional program in MLL-EEN leukemia, American Association for Cancer Research (AACR) Annual Meeting April 1-5,2017, Washington DC, USA. 2017.

Researcher : Lui WYV

Project Title:	A Precision Therapeutic Tool for Head and Neck Cancer (HNC)
Investigator(s):	Lui WYV
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	Seed Fund for Translational and Applied Research
Start Date:	03/2015

Project Title:	HKU Overseas Fellowship Awards 2015-16
Investigator(s):	Lui WYV
Department:	Pharmacology & Pharmacy
Source(s) of Funding:	HKU Overseas Fellowship Awards
Start Date:	06/2015

List of Research Outputs

Li Y.Y., Chung G.T., Lui W.Y.V., To K.F., Ma B.B., Chow C., Woo J.K., Yip K.Y., Seo J., Hui E.P., Mak M.K., Rusan M., Chau N.G., Or Y.Y., Law M.H., Law P.P., Liu Z.W., NGAN H.L., Hau P.M., Verhoeft K.R., Poon P.H., Yoo S.K., Shin J.Y., Lee S.D., Lun S.W., Jia L.J., Chan A.W., Chan J.Y., Lai P.B., Fung C.Y., Hung S.T., Wang L., Chang A.M., Chiosea S.I., Hedberg M.L., Tsao G.S.W., van Hasselt A.C., Chan A.T., Grandis J.R., Nature Communications P.S. and Lo K.W., Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations, Nature Communications. 2017.

NGAN H.L., Tsao G.S.W. and Lui W.Y.V., MAPK Pathway Mutations in Head and Neck Squamous Cell Carcinoma (HNSCC), 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

Researcher : Lyu Q

List of Research Outputs

Researcher : MA SKY

List of Research Outputs

CHAI S., Ng K.Y., Tong M., Lau Y.T., Lee K.W., Chan K.W., Yuan Y.F., Cheung T.T., Cheung S.T., Wang X., Wong N., Lo C.M., Man K., Guan X. and Ma S.K.Y., Oct4/miR-1246 signaling axis drives Wnt/β-catenin activation in liver cancer stem cells, Hepatology. 2016.

CHAN L.H. and Ma S.K.Y., PRMT6-Dependent CRAF/ERK Signaling Regulates Cancer Stem Cell Plasticity in Liver Cancer, 4th International Anatomical Sciences & Cell Biology Conference. 2016.

Fung T.M., Ng K.Y., Tong M., CHEN J., Chai S., Chan K.T., Law S.Y.K., Lee N.P.Y., Choi M.Y., Li B., Cheung A., Tsao G.S.W., Qin Y.R., Guan X., Chan K.W. and Ma S.K.Y., Neuropilin-2 promotes tumourigenicity and metastasis in oesophageal squamous cell carcinoma through ERK-MAPK-ETV4-MMP-E-cadherin deregulation, Journal of Pathology. 2016, 239(3): 309-319.

Kong K.Y., Deng J., GAO W., Tang H.M.V., CHAUDHARY V., CHENG Y., Wong D.K.H., Yuen R.M.F., Ma S.K.Y., Chan C.P. and Jin D., PRMT5 protein arginine methyltransferase activates hepatitis B virus transcription., 2016 International HBV Meeting.. Seoul, Korea, 2016.

LUK T.C.S., Tong M., Ng K.Y., Guan X. and Ma S.K.Y., Identification of REX1 as a Regulator of Cancer Stemness in CD133+ Liver Cancer Stem Cells by Genome-wide DNA Methylation Analysis, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

Li J., Zhang B.Z., Qin Y.R., Bi J., Liu H.B., Li Y., Ma S.K.Y., Chan K.W., Xie D. and Guan X., CD68 and interleukin 13, prospective immune markers for esophageal squamous cell carcinoma prognosis prediction, Oncotarget. 2016, 7: 15525-38.

MA S.K.Y., Planarian collagens and their roles during regeneration (PhD thesis), The University of Hong Kong. 2017.

Ma S.K.Y., Deciphering ZIC2/OCT4 signaling as a vulnerability in liver cancer stem cells, Translational Cancer Research. 2016.

Ma S.K.Y., Exploiting ‘stemness’ as a cancer cell vulnerability, 4th International Anatomical Sciences and Cell Biology Conference. 2016.

Ma S.K.Y., Exploiting ‘stemness’ as a cancer cell vulnerability, Korea Gynecologic Cancer Registry (KGCR) 2017 Meeting, Deagu, South Korea. 2017.

Ma S.K.Y., PRMT6-dependent CRAF/ERK signaling regulates cancer stem cell plasticity in liver cancer, Cancer Stem Cell 2016 – Short Talk, Cleveland, Ohio, USA. 2016.

Ma S.K.Y., Potential of targeting cancer stem cells for the treatment of hepatocellular carcinoma, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, South Korea. 2017.

Ma S.K.Y., Translational Cancer Research. 2017.

Ng K.Y., CHAI S., Tong M., Guan X., Lin C., Ching Y.P., Xie D., Cheng A.S. and Ma S.K.Y., C-terminal truncated hepatitis B virus X protein promotes hepatocellular carcinogenesis through induction of cancer and stem cell-like properties, Oncotarget. 2016.

Ng K.Y. and Ma S.K.Y., Tumor suppressor TP53INP1 negatively regulates ERK1/2 via DUSP10 to promote metastasis in hepatocellular carcinoma, 4th International Anatomical Sciences & Cell Biology Conference. 2016.

Tang K.D., Liu J., Jovanovic L., An J., Hill M.M., Vela I., Lee K.W., Ma S.K.Y., Nelson C., Russell P.J., Clements J.A. and Ling M.T., Adipocytes promote prostate cancer stem cell self-renewal through amplification of the cholecystokinin autocrine loop, Oncotarget. 2016, 7: 4939-48.

Wong T.L., CHE N. and Ma S.K.Y., Reprogramming of Central Carbon Metabolism in Cancer Stem Cells, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2017, 1863: 1728-1738.

Researcher : MUHAMMAD SHARAFUDDIN BIN MK

List of Research Outputs

Lim L.W., Shrestha S., Or Y.Z., TAN Z.K.S., Chung H.H., Sun Y.A.N.G., Lim C.H.E.W. .L.E.N.G., MUHAMMAD SHARAFUDDIN BIN M.K., Lufkin T. and Lin V.C.L., Tetratricopeptide repeat domain 9A modulates anxiety-like behavior in female mice , Scientific Reports. 2016, 37568.

MUHAMMAD SHARAFUDDIN BIN M.K., Lim W.L., Fung W.W.L., Temel Y. and Lim L.W., Electrical stimulation rescues dopaminergic degeneration in the dorsal raphe nucleus and enhanced hippocampal neurogenesis of vulnerable depressive-like rats., 14th Meeting of the Asian-Pacific Society for Neurochemistry, Malaysia.. Frontiers in Cellular Neuroscience, 2016.

MUHAMMAD SHARAFUDDIN BIN M.K., Lim W.L., Temel Y. and Lim L.W., Electrical stimulation rescues dopaminergic neurodegeneration in the dorsal raphe nucleus of vulnerable depressive-like rats, 4th International Anatomical Sciences & Cell Biology Conference, Hong Kong.. 2016.

MUHAMMAD SHARAFUDDIN BIN M.K., Lim W.L., Fung W.L., Temel Y. and Lim L.W., Travel Fellowship Award, Asian-Pacific Society for Neurochemistry . 2016.

TAN Z.K.S., MUHAMMAD SHARAFUDDIN BIN M.K., Hescham S., Blokland A., Temel Y. and Lim L.W., Deep brain stimulation of the entorhinal cortex or perifornical area in an aged animal model transiently restores memory function., The Francis Crick Symposium, Suzhou, China. 2017.

TAN Z.K.S., Lim L.W., Shrestha S., OR Y.Z., Chung H.H., Sun Y., Lim C.L., MUHAMMAD SHARAFUDDIN BIN M.K., Lufkin T. and Lin V.C.L., Tetratricopeptide repeat domain 9A modulates anxiety-like behavior in female mice, 4th International Anatomical Sciences & Cell Biology Conference, Hong Kong.. 2016.

Researcher : Ma CW

List of Research Outputs

Chan Y.S., Botelho F.P., Ma C.W., Shi W. and Shum D.K.Y., Developmental plasticity of brain circuits for navigational behavior. Frontiers in Cellular Neuroscience [14^th Meeting of Asian-Pacific Society for Neurochemistry, Kuala Lumpur August 27-30, 2016. 2016.

Chan Y.S., Ma C.W., Shi W. and Shum D.K.Y., Wiring of functional brain circuits for spatial orienting behavior, [International Conference of Physiological Sciences 2016 Beijing. September 25-28, 2016]. 2016.

JIANG Q., Ma C.W., Shum D.K.Y. and Chan Y.S., Antidepressant reactivates the plasticity of vestibular-dependent navigation in the adult, Soc. Neuroscience Abstract (USA) , 264.14 [San Diego. Nov. 12-16, 2016]. 2016.

JIANG Q., Ma C.W., Shum D.K.Y. and Chan Y.S., Antidepressant reinstates the plasticity of vestibular-mediated navigation in the adult, Abstracts of 12^th Int’l Symp. on Healthy Aging: Science and Aging – Wellness and Longevity: From Science to Service: 61. [HK. March 11-12, 2017]. 2017.

JIANG Y., LAM T.F., Ma C.W., Shum D.K.Y., WANG J.J. and Chan Y.S., Modulatory role of orexin on synaptic transmission in the central vestibular system, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

JIANG Y., Lam T.F.U., Ma C.W., Shum D.K.Y., Wang J.J. and Chan Y.S., Modulatory role of orexin on synaptic transmission in the central vestibular system, Soc. Neuroscience Abstract (USA), 803.04 [San Diego. Nov. 12-16, 2016]. 2016.

JIANG Y., LAM T.F., Ma C.W., Shum D.K.Y., Wang J.J. and Chan Y.S., Orexin regulates synaptic transmission within the rat vestibular nucleus, Abstracts of 12^th Int’l Symp. on Healthy Aging: Science and Aging – Wellness and Longevity: From Science to Service : 64. [HK. March 11-12, 2017]. 2017.

KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Role of perineuronal chondroitin sulfates and semaphorin3A in the maturation of the vestibular circuitry, Abstracts of 10^th FENS Forum of Neuroscience, 2349. [Copenhagen, Denmark. July 2-6, 2016]. 2016.

LAM T.F., Ma C.W., Shum D.K.Y., Wang J.J. and Chan Y.S., Behavioral expression of orexin-modulated transmission in the vestibular nucleus of postnatal rats, Neuroscience 2016 of the Society for the Neurosciences. 2016.

Lam T.F.U., Ma C.W., Shum D.K.Y., Wang J.J. and Chan Y.S., Behavioral expression of orexin-modulated transmission in the vestibular nucleus of postnatal rats, Soc. Neuroscience Abstract (USA), 803.09 [San Diego. Nov. 12-16, 2016]. 2016.

Shum D.K.Y., KWAN P.Y., Ma C.W. and Chan Y.S., The regulatory roles of perineuronal semaphorin 3A and chondroitin sulfates on the developing vestibular circuitry, Soc. Neuroscience Abstract (USA), 677.17 [San Diego. Nov. 12-16, 2016]. 2016.

Researcher : Ma SKY

Project Title:	Hepatitis B virus promotes hepatocarcinogenesis through induction of CD133+ cancer stem cells/tumor-initiating cells
Investigator(s):	Ma SKY, Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	01/2013
Completion Date:	10/2016

Project Title:	Significance of Annexin A3 in CD133+ Cancer-Initiating Cells-Driven Hepatocellular Carcinoma
Investigator(s):	Ma SKY, Chan KW
Department:	Clinical Oncology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2013
Completion Date:	11/2016

Project Title:	Outstanding Young Researcher Award 2012-13
Investigator(s):	Ma SKY
Department:	Anatomy
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	01/2014

Project Title:	A multidisciplinary study on hepatic cancer stem cells
Investigator(s):	Ma SKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Croucher Innovation Awards
Start Date:	04/2014

Project Title:	Regulatory role of microRNA-1246 and Wnt/β-catenin pathway interaction in CD133+ liver cancer stem cells-driven hepatocellular carcinoma
Investigator(s):	Ma SKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	01/2015

Project Title:	PRMT6 in the control of glucose metabolic reprogramming in CD133+ liver cancer stem cells
Investigator(s):	Ma SKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2015
Completion Date:	08/2016

Project Title:	A Multidisciplinary Study on CD133 Liver Cancer Stem Cells: Molecular Mechanisms, Clinical Relevance and Therapeutic Implications
Investigator(s):	Ma SKY, Guan X, Lo CM, Man K
Department:	School of Biomedical Sciences
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2015

Project Title:	PRMT6 regulates ERK1/2 signal transduction in liver cancer through CRAF
Investigator(s):	Ma SKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2016
Completion Date:	09/2017

Project Title:	Establishment of a novel ANXA3 neutralizing antibody and its use, alone or in combination with sorafenib, as a potential therapeutic regimen against liver cancer
Investigator(s):	Ma SKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Translational and Applied Research
Start Date:	05/2016
Completion Date:	04/2017

Project Title:	Role of PRMT6 in regulating cancer and stemness properties in hepatocellular carcinoma
Investigator(s):	Ma SKY, Leung SY, Yan HHN
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2016

Project Title:	AACR Annual Meeting; Octamer-4/microRNA-1246 signaling axis drives Wnt/β-catenin activation in liver cancer stem cells
Investigator(s):	Ma SKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2017
Completion Date:	04/2017

Project Title:	Role of MAPK11 in liver cancer stem cells
Investigator(s):	Ma SKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2017

Project Title:	A Multidisciplinary Study on CD133 Liver Cancer Stem Cells: Molecular Mechanisms, Clinical Relevance and Therapeutic Implications (CRF)
Investigator(s):	Ma SKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Funding for Strategic Interdisciplinary Research Scheme
Start Date:	06/2017

List of Research Outputs

CHAN L.H. and Ma S.K.Y., PRMT6-Dependent CRAF/ERK Signaling Regulates Cancer Stem Cell Plasticity in Liver Cancer, 4th International Anatomical Sciences & Cell Biology Conference. 2016.

MA S.K.Y., Planarian collagens and their roles during regeneration (PhD thesis), The University of Hong Kong. 2017.

Ma S.K.Y., Deciphering ZIC2/OCT4 signaling as a vulnerability in liver cancer stem cells, Translational Cancer Research. 2016.

Ma S.K.Y., Exploiting ‘stemness’ as a cancer cell vulnerability, 4th International Anatomical Sciences and Cell Biology Conference. 2016.

Ma S.K.Y., Exploiting ‘stemness’ as a cancer cell vulnerability, Korea Gynecologic Cancer Registry (KGCR) 2017 Meeting, Deagu, South Korea. 2017.

Ma S.K.Y., PRMT6-dependent CRAF/ERK signaling regulates cancer stem cell plasticity in liver cancer, Cancer Stem Cell 2016 – Short Talk, Cleveland, Ohio, USA. 2016.

Ma S.K.Y., Potential of targeting cancer stem cells for the treatment of hepatocellular carcinoma, Dongsan Medical Center, Keimyung University School of Medicine, Daegu, South Korea. 2017.

Ma S.K.Y., Translational Cancer Research. 2017.

Wong T.L., CHE N. and Ma S.K.Y., Reprogramming of Central Carbon Metabolism in Cancer Stem Cells, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2017, 1863: 1728-1738.

Researcher : Machado MD

List of Research Outputs

Bullock S., Simmons M., McArdle A., Machado M.D., Middleton S., Reser D., Shuttleworth M. and Tare M., Recognition of Educational Excellence and Innovation, Monash University. 2017.

Researcher : Man SC

List of Research Outputs

PANG C.C.C., Man S.C., Lee K., Noble W. and Chang R.C.C., Establishing a pre-clinical therapeutic platform to screen for dementia therapeutics. , International Alzheimer’s Disease Conference 2017. 41.

PANG C.C.C., Man S.C., Nobel W. and Chang R.C.C., Investigating the impacts of Parkinson’s disease dementia (PDD) by using an animal model in PDThe 12th International Symposium on Healthy Aging, The 12th International Symposium on Healthy Aging. 2017, 64.

Researcher : NG HM

List of Research Outputs

GUO Y., AN L., NG H.M., Sy M.H. and Huen M.S.Y., An E2-guided E3 Screen Identifies the RNF17-UBE2U Pair as Regulator of the Radiosensitivity, Immunodeficiency, Dysmorphic Features, and Learning Difficulties (RIDDLE) Syndrome Protein RNF168., Journal Of Biological Chemistry. 2017, 292: 967-978.

NG H.M., Role of the BRCC36 Deubiquitylase in DNA Damage Signaling and DNA (PhD Thesis), The University of Hong Kong. 2017.

Ng H.M., Wei L., Lan L. and Huen M.S.Y., The Lys63-deubiquitylating Enzyme BRCC36 Limits DNA Break Processing and Repair , Journal of Biological Chemistry. 2016, 291: 16197-16207.

Researcher : NGAN HL

List of Research Outputs

Li Y.Y., Chung G.T., Lui W.Y.V., To K.F., Ma B.B., Chow C., Woo J.K., Yip K.Y., Seo J., Hui E.P., Mak M.K., Rusan M., Chau N.G., Or Y.Y., Law M.H., Law P.P., Liu Z.W., NGAN H.L., Hau P.M., Verhoeft K.R., Poon P.H., Yoo S.K., Shin J.Y., Lee S.D., Lun S.W., Jia L.J., Chan A.W., Chan J.Y., Lai P.B., Fung C.Y., Hung S.T., Wang L., Chang A.M., Chiosea S.I., Hedberg M.L., Tsao G.S.W., van Hasselt A.C., Chan A.T., Grandis J.R., Nature Communications P.S. and Lo K.W., Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations, Nature Communications. 2017.

NGAN H.L., Tsao G.S.W. and Lui W.Y.V., MAPK Pathway Mutations in Head and Neck Squamous Cell Carcinoma (HNSCC), 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

NGAN H.L. and LUI V.W.Y., Potential clinical significance of downregulation of MAPK pathway components’ mRNA expressions in head and neck squamous cell carcinoma (HNSCC), 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : Ng HLL

List of Research Outputs

An L., Jiang Y., Ng H.L.L., Man P.S., Chen J., Khoo U.S., Gong Q. and Huen M.S.Y., Dual-utility NLS drives RNF169-dependent DNA damage responses, Proc Natl Acad Sci U S A. 2017, 114(14): E2872-E2881.

Researcher : Ng HWH

List of Research Outputs

AN L., Jiang Y.Y., Ng H.W.H., Chen J., Gong Q.G. and Huen M.S.Y., A Dual Utility NLS Drives RNF169-dependent DNA Damage Responses, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

AN L., JIANG Y., Ng H.W.H., Man P.S., CHEN J., Khoo U.S., Gong Q. and Huen M.S.Y., Dual-utility NLS Drives RNF169-dependent DNA Damage Responses, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : Ng KY

Project Title:	Role of LOXL1 in CD133+ liver cancer stem cells driven hepatocellular carcinoma
Investigator(s):	Ng KY, Huen MSY, Ma SKY
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	05/2015
Completion Date:	10/2016

Project Title:	AACR Annual Meeting 2017; TP53INP1 negatively regulates ERK1/2 via p73-dependent DUSP10 expression to promote metastasis in hepatocellular carcinoma
Investigator(s):	Ng KY
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2017
Completion Date:	04/2017

List of Research Outputs

CHAI S., Ng K.Y., Tong M., Lau Y.T., Lee K.W., Chan K.W., Yuan Y.F., Cheung T.T., Cheung S.T., Wang X., Wong N., Lo C.M., Man K., Guan X. and Ma S.K.Y., Oct4/miR-1246 signaling axis drives Wnt/β-catenin activation in liver cancer stem cells, Hepatology. 2016.

Fung T.M., Ng K.Y., Tong M., CHEN J., Chai S., Chan K.T., Law S.Y.K., Lee N.P.Y., Choi M.Y., Li B., Cheung A., Tsao G.S.W., Qin Y.R., Guan X., Chan K.W. and Ma S.K.Y., Neuropilin-2 promotes tumourigenicity and metastasis in oesophageal squamous cell carcinoma through ERK-MAPK-ETV4-MMP-E-cadherin deregulation, Journal of Pathology. 2016, 239(3): 309-319.

LUK T.C.S., Tong M., Ng K.Y., Guan X. and Ma S.K.Y., Identification of REX1 as a Regulator of Cancer Stemness in CD133+ Liver Cancer Stem Cells by Genome-wide DNA Methylation Analysis, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

Ng K.Y., CHAI S., Tong M., Guan X., Lin C., Ching Y.P., Xie D., Cheng A.S. and Ma S.K.Y., C-terminal truncated hepatitis B virus X protein promotes hepatocellular carcinogenesis through induction of cancer and stem cell-like properties, Oncotarget. 2016.

Ng K.Y. and Ma S.K.Y., Tumor suppressor TP53INP1 negatively regulates ERK1/2 via DUSP10 to promote metastasis in hepatocellular carcinoma, 4th International Anatomical Sciences & Cell Biology Conference. 2016.

Researcher : Ng RK

Project Title:	Dysregulation of DNA methylation in MLL-rearranged leukemia
Investigator(s):	Ng RK
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2015

Project Title:	The role of BMI-1 in regulation of JAK-STAT signaling pathway in human leukemia
Investigator(s):	Ng RK, Yiu SM
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2015

Project Title:	Epigenetic regulation of enhancer RNA in MLL-rearranged leukemia
Investigator(s):	Ng RK
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

Project Title:	Epigenetic function of TET2 in the transcriptional regulation of MLL-rearranged leukemia
Investigator(s):	Ng RK, Wang JJ
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2016

Project Title:	Epigenomics of Common Diseases conference; Dysregulation of DNA methylation at gene regulatory regions in MLL-rearranged leukemia
Investigator(s):	Ng RK
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2016
Completion Date:	11/2016

Project Title:	Regulation of JNK signaling pathway by reactive oxygen species in the differentiation of acute myeloid leukemia cells
Investigator(s):	Ng RK
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

List of Research Outputs

Lam Y.M., Chan Y.F., Chan L.C. and Ng R.K., Histone deacetylase inhibitors induce leukemia gene expression in cord blood hematopoietic stem cells expanded ex vivo, International journal of hematology. 2017, 105: 37-43.

Lam Y.M., LAM S.Y., Leung A.Y.H. and Ng R.K., Tumor suppressive role of BMI-1 through inhibition of JAK-STAT signaling in leukemia, American Association for Cancer Research (AACR) Annual Meeting April 1-5,2017, Washington DC, USA. 2017.

Ng R.K., Critical roles of epigenetics in leukemia gene transcription and cellular signaling, Hubei University of Medicine. Hubei, China, 2016.

Ng R.K., YANG X. and Lam Y.M., Dysregulation of DNA methylation at gene regulatory regions in MLL-rearranged leukemia, Epigenomics of Common Diseases November 1-4, 2016, Cambridge, UK. 2016.

Ng R.K., Epigenetic dysregulation in leukemia transcriptional program, School of Biomedical Sciences, The Chinese University of Hong Kong. Hong Kong, 2017.

QIN Y., Ng R.K., Ng T.W., Tong K.K., Au Y.K., Niu B., Tan Z., Yip M.S., Wang J.J., Sham P.C. and Cheah K.S.E., Genome-wide identification of active enhancers in the developing mouse nucleus pulposus, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

YANG X., Lam Y.M., Lui W.C. and Ng R.K., Epigenetic dysregulation of transcriptional program in MLL-EEN leukemia, American Association for Cancer Research (AACR) Annual Meeting April 1-5,2017, Washington DC, USA. 2017.

Researcher : Ng TW

Project Title:	Evaluating the effect of prostaglandin-E2 EP4 receptor signaling
Investigator(s):	Ng TW, Chang RCC
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	04/2015
Completion Date:	09/2016

List of Research Outputs

QIN Y., Ng R.K., Ng T.W., Tong K.K., Au Y.K., Niu B., Tan Z., Yip M.S., Wang J.J., Sham P.C. and Cheah K.S.E., Genome-wide identification of active enhancers in the developing mouse nucleus pulposus, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : Ngan WL

List of Research Outputs

Ho J.W.Y., Ngan W.L., Chan L.K., Cook S. and Bridges S.M., Assessments for Learning - A Double Edged-Sword? , Frontiers in Medical and Health Sciences Education. 2016.

Researcher : Ni Y

Project Title:	Three-Dimensional Super-Resolution Visualization of specific non-repetitive DNA in Single Mammalian Cells
Investigator(s):	Ni Y, Huang J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Small Project Funding
Start Date:	03/2015

List of Research Outputs

Ni Y., Cao B., Ma T., Niu G., Huo Y., Huang J., Chen D., Liu Y., Yu B. and Zhang M., Super-resolution imaging of a 2.5 kb non-repetitive DNA in situ in the nuclear genome using molecular beacon probes, eLife. 2017, 2050084X.

Researcher : Niu B

Project Title:	Whole genome identification of active core promoters, enhancers and insulators in mouse growth plate
Investigator(s):	Niu B, Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	01/2010

List of Research Outputs

QIN Y., Ng R.K., Ng T.W., Tong K.K., Au Y.K., Niu B., Tan Z., Yip M.S., Wang J.J., Sham P.C. and Cheah K.S.E., Genome-wide identification of active enhancers in the developing mouse nucleus pulposus, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : OENTARYO MJ

List of Research Outputs

CHAN C.K. and OENTARYO M.J., Xenopus nerve-muscle cultures: a novel cell-based assay for serological diagnosis and pathological research of myasthenia gravis, Current Pathobiology Reports. 2017, 5(1): 57-65.

Researcher : Osorio Da Silva LA

List of Research Outputs

LONG F., Osorio Da Silva L.A., WU X. and Zhou Z., ISM1 in mammary gland morphogenesis and its malignant transformation, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : PAN J

List of Research Outputs

Guo R., Lin B., PAN J., Liong E.C., Xu A., Youdim M., Fung M.L., So K.F. and Tipoe G.L., Inhibition of caspase-9 aggravates acute liver injury through suppression of cytoprotective autophage, Scientific Reports. 2016, 6: 32447.

Researcher : PAN W

List of Research Outputs

PAN W., HO H.H., Hui C.C. and Sham M.H., Regulation of mammalian hindbrain neural progenitor proliferation and differentiation by Suppressor of fused and β-catenin, 18th International Congress of Developmental Biology. 2017.

PAN W., HOR H.H.C., Hui C.C. and Sham M.H., Suppressor of fused regulates neural progenitor cell cycle progression during mammalian hindbrain neurogenesis, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : PANG CCC

List of Research Outputs

PANG C.C.C., Man S.C., Lee K., Noble W. and Chang R.C.C., Establishing a pre-clinical therapeutic platform to screen for dementia therapeutics. , International Alzheimer’s Disease Conference 2017. 41.

PANG C.C.C. and Chang R.C.C., Investigating tau and alpha-synuclein in Parkinson’s disease dementia model., The 13th International Conference on Alzheimer’s & Parkinson’s Diseases 2017, Section B01.a Disease mechanisms, pathophysiology: tau aggregation, phosphorylation, acetylation & modifications. . 2017, 137.

PANG C.C.C., Noble W. and Chang R.C.C., Investigating the impacts of Parkinson’s Disease Dementia (PDD) by using an animal model in PD, 4th International Anatomical Sciences & Cell Biology Conference. 2016.

PANG C.C.C., Man S.C., Nobel W. and Chang R.C.C., Investigating the impacts of Parkinson’s disease dementia (PDD) by using an animal model in PDThe 12th International Symposium on Healthy Aging, The 12th International Symposium on Healthy Aging. 2017, 64.

Researcher : Poon AMS

List of Research Outputs

Hung M.W., Yeung H.M., Lau C.F., Poon A.M.S., Tipoe G.L. and Fung M.L., Melatonin attenuates pulmonary hypertension in chronically hypoxic rats, International Journal of Molecular Sciences. 2017, 18(6): 1125.

Researcher : Poon NYE

Project Title:	The effect of miR-200c on the electrophysiological maturation of human embryonic stem cell derived cardiomyocytes
Investigator(s):	Poon NYE, Boheler KR, Li RA
Department:	School of Biomedical Sciences
Source(s) of Funding:	Small Project Funding
Start Date:	03/2014

Project Title:	Identification of the optimal source of human mesenchymal stromal cells for the treatment of acute graft-versus-host disease under a clinical-grade ex-vivo culture system
Investigator(s):	Poon NYE, Chan GCF, Boheler KR
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	08/2016

Researcher : QIN T

List of Research Outputs

HO C.C., QIN T., Wang B., Wong Y.M.E., LIU Y., Hui C.C. and Sham M.H., Sufu controls the proliferation and differentiation of cochlear prosensory progenitors, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

HO C.C., QIN T., Wang B., Wong Y.M.E., LIU Y., Hui C.C. and Sham M.H., Sufu regulates the proliferation and differentiation of hair cell progenitors in mammalian cochlea, 18th International Congress of Developmental Biology. 2017.

Researcher : QIN Y

List of Research Outputs

MAK S.L., Yung M.H., Hui M.N., LEUNG L.L., LIANG R., CHEN K., Liu S., QIN Y., Lee C.K.F., Chan K.K.L., Ngan H.Y.S. and Chan D.W., Dysregulation of miR-141/KLF12/Sp1/surviving signaling promotes anoikis resistance in ovarian cancer metastatic progression, Molecular Cancer. 2017.

QIN Y., Ng R.K., Ng T.W., Tong K.K., Au Y.K., Niu B., Tan Z., Yip M.S., Wang J.J., Sham P.C. and Cheah K.S.E., Genome-wide identification of active enhancers in the developing mouse nucleus pulposus, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Zhang Y., CHIU S.M., LIANG X., Chai Y.H., QIN Y., Wang J., LI X., Qiu B., Tergaonkar V., Tse H.F. and Lian Q., Absence of NUCKS augments paracrine effects of mesenchymal stem cells-mediated cardiac protection, Experimental Cell Research. Elsevier, 2017, 356: 74-84.

Researcher : Qian C

Project Title:	Structure-Based Mechanistic Insights into Timeless-Involved Replication Fork Protection
Investigator(s):	Qian C
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2013

Project Title:	Structural and Mechanistic Studies of Human SLX4 Complex in Interstrand Crosslink Repair
Investigator(s):	Qian C
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2014

Project Title:	Structural & Mechanistic Analysis of BAF Chromatin Remodeling Complex
Investigator(s):	Qian C
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2015

Project Title:	Structural and Mechanistic Insights into DNMT1-mediated Maintenance DNA Methylation
Investigator(s):	Qian C
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016
Completion Date:	06/2017

Project Title:	New Mechanistic Insights into DNMT1-mediated Maintenance DNA Methylation
Investigator(s):	Qian C, Zhou Z
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2016

Project Title:	Drug development targeting a novel protein complex in rRNA transcription
Investigator(s):	Qian C
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

List of Research Outputs

Qian C., New Mechanistic Insights into Dnmt1-Mediated Maintenance DNA Methylation, 2016 Gordon Research Conference on Genomic Instability. 2016.

Qian C., New Mechanistic Insights into PARP-1-mediated DNA Damage Response, City University of Hong Kong. 2016.

Qian C., New mechanistic Insights into DNMT1-mediated Maintenance DNA Methylation, 2017 Gordon Research Conference on Geminal Stem Cell Biology. 2017.

YAN L., Xie S., DU Y. and Qian C., Structural Insights into BAF47 and BAF155 Complex Formation, Journal of Molecular Biology. 2017, 429: 1650-1660.

YAN L., Xie S., DU Y. and Qian C., Structural and Biochemical Study of Core Regulatory Machinery of BAF Chromatin Remodeling Complex, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

YAN L., Xie S., DU Y. and Qian C., Structural insights into BAF47 and BAF155 complex formation, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : RAO Y

List of Research Outputs

Cheung M.C.H., RAO Y., Cheung M.P.L., Sharma R. and Cheah K.S.E., Asymmetric localization of Dlc1 defines trunk neural crest polarity for directional delamination and migration, International Congress of Developmental Biolog. Elsevier, 2017, 145: S65.

RAO Y., Liang Y. and PENG B., A revisit of rod microglia in preclinical studies, Neural Regeneration Research. 2017, 0: 0.

RAO Y., Dlc1, a Rho GTPase-activating Protein, is Essential for Cranial Neural Crest Development, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

RAO Y., Liu A.J., Cheung M.P.L. and Cheung M.C.H., Dlc1, a Rho GTPase-activating protein, is essential for cranial neural crest development, 4th International Anatomical Sciences & Cell Biology Conference. 2016.

Researcher : RUVEN C

List of Research Outputs

RUVEN C. and Wu W., Transplantation of embryonic spinal cord derived cells to prevent muscle atrophy after various peripheral nerve injuries, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : SHAH AM

List of Research Outputs

SHAH A.M., Cell and Tissue Interaction in Intervertebral Disc Maintenance, The University of Hong Kong. 2017.

Researcher : SHAH AN

List of Research Outputs

SHAH A.N., Hung H.L.C., Cheng S.Y., WONG M.Y., Legido-Quigley C. and Chang R.C.C., Oxyresveratrol mitigates cellular toxicity in and in-vitro and in-vivo model of Parkinson’s disease, The 13th International Conference on Alzheimer’s & Parkinson’s Diseases 2017, Section C02.g Therapeutic targets, mechanisms for treatment: anti- inflammatory, anti-oxidant.. 2017, 146.

WONG M.Y., SHAH A.N., CHENG S.Y. and Chang R.C.C., Effects on Oxyresveratrol on Motor and Cognitive Functions in 6-OHDA-Induced Parkinson’s Disease, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

WONG M.Y., SHAH A.N. and Chang R.C.C., Protective effects of oxyresveratrol on motor functions in 6-OHDA-Induced neurodegeneration, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

WONG M.Y., SHAH A.N. and Chang R.C.C., Protective effects of oxyresveratrol on motor functions in 6-OHDA-induced neurodegeneration. , The 12th International Symposium on Healthy Aging. 2017, 79.

Researcher : SHIU CC

List of Research Outputs

Cheung Y.W., SHIU C.C., FRASER L.A., LIANG S., Dirkzwager R.M., Kinghorn A.B., TANG S.L.M. and Tanner J.A., Aptamer-mediated biosensing: from malaria diagnosis to DNA nanostructure dynamics, 5th International Conference on Bio-Sensing Technology. 2017.

Cheung Y.W., SHIU C.C., Wong W.C., TANG S.L.M., DIRKZWAGER R.M., LIANG S., KINGHORN A.B., FRASER L.A. and Tanner J.A., From DNA aptamer structure to splitting for use in DNA nanotweezers, Oligo 2017 Oxford: Antisense & Therapeutic Nucleic Acids. 2017.

KINGHORN A.B., DIRKZWAGER R.M., LIANG S., Cheung Y.W., FRASER L.A., SHIU C.C., TANG S.L.M. and Tanner J.A., Aptamer Affinity Maturation by Resampling and Microarray Selection, Analytical Chemistry. American Chemical Society, 2016, 88: 6981-6985.

Miranda G.F., Feng L., SHIU C.C., DIRKZWAGER R.M., Tanner J.A., Schöning M.J., Offenhäusser A. and Mayer D., Aptamer-based electrochemical biosensor for highly sensitive and selective malaria detection, 1st International Symposium for Biomedical Research. 2017.

SHIU C.C., Cheung Y.W., DIRKZWAGER R.M., LIANG S., Kinghorn A.B., FRASER L.A., TANG S.L.M. and Tanner J.A., A split aptamer can facilitate protein recognition in DNA nanotweezers, Aptamers 2017, 4th Oxford Symposium on Aptamers. 2017.

SHIU C.C., Cheung Y.W., LIANG S., Kinghorn A.B., LIANG S., TANG S.L.M. and Tanner J.A., An Aptamer-Mediated DNA Nano-Switch, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

SHIU C.C., Cheung Y.W., DIRKZWAGER R.M., LIANG S., Kinghorn A.B., FRASER L.A., TANG S.L.M. and Tanner J.A., Aptamer-Mediated Protein Molecular Recognition Driving a DNA Tweezer Nanomachine, Advanced Biosystems. 2017, 1: 1600006.

SHIU C.C., Cheung Y.W., Dirkzwager R.M., LIANG S., Kinghorn A.B., FRASER L.A., Tang S.L.M. and Tanner J.A., DNA Tweezer Nanomachine Mediated by Heterogeneous Recognition, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

SHIU C.C., TANG S.L.M., DIRKZWAGER R.M., LIANG S., Kinghorn A.B., Cheung Y.W., FRASER L.A., Godonoga M., Heddle J.G. and Tanner J.A., Protein driven aptamer toehold switches integrated into DNA origami nanostructures, Oligo 2017 Oxford: Antisense & Therapeutic Nucleic Acids. 2017.

Researcher : SIT HM

List of Research Outputs

LI Z., LEUNG C., SIT H.M. and Sham M.H., Defective cell adhesion and cell migration in Sox10 mutant neural crest, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

LI Z., LEUNG C., SIT H.M. and Sham M.H., Dysregulation of cell adhesion and cell migration genes in Sox10 mutant neural crest, 18th International Congress of Developmental Biology. 2017.

ZHOU Y., Zhang Y.G., CAO F., SIT H.M., Tsao G.S.W. and Yu C., Define the Functional Role of Myosin-1e at the Macrophage Podosome, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

Researcher : SO KH

List of Research Outputs

SO K.H., Kudelko M.A., Tan Z., Wang C., Chan W.C.W., Tsang K.Y., Cheah K.S.E. and Chan D., FGF21 Up-Regulates Glycolytic Proteins for Hypertrophic Chondrocyte Survival under ER Stress, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : SO PY

List of Research Outputs

SO P.Y., Functional Characterization of the Role of Cancer Stem Cell Marker, Prominin-1 (CD133), in Hepatocellular Carcinoma (MPhil Thesis), The University of Hong Kong. 2016.

Researcher : Sham MH

Project Title:	International Congress on Differentation and Cell Biology Neural-specific Cis-acting and Trans-acting Regulation of the Mouse Hoxb-3 Gene During Embryogenesis
Investigator(s):	Sham MH
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2000

Project Title:	Outstanding Research Student Supervisor Award 2008-2009
Investigator(s):	Sham MH
Department:	Biochemistry
Source(s) of Funding:	Outstanding Research Student Supervisor Award
Start Date:	12/2009

Project Title:	Visiting Research Professors Scheme 2010-11
Investigator(s):	Sham MH
Department:	School of Biomedical Sciences
Source(s) of Funding:	Visiting Research Professors Scheme
Start Date:	09/2010

Project Title:	The roles of Suppressor of fused (Sufu) in the maintenance of mammalian neural progenitor cells
Investigator(s):	Sham MH
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	The interactions of EyaI and Notch signaling in the branchial epithelia during mammalian craniofacial development
Investigator(s):	Sham MH
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016

Project Title:	Modulation of Notch Signaling by EYA1 in Breast Cancer
Investigator(s):	Sham MH
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2016

Project Title:	The roles of N-Myc, Sufu and Gli genes in regulating the dynamic progression of mammalian cochlear hair cell differentiation
Investigator(s):	Sham MH
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2017

List of Research Outputs

Burns A.J., Goldstein A.M., Newgreen D.F., Stamp L., Schafer K.H., Metzger M., Hotta R., Young H.M., Andrews P.W., Thapar N., Belkind-Gerson J., Bondurand N., Bornstein J.C., Chan W.Y., Cheah K.S.E., Gershon M.D., Heuckeroth R.O., Hofstra R.M.W., Just L., Kapur R.P., King S.K., McCann C.J., Nagy N., Ngan E.S.W., Obermayr F., Pachnis V., Pasricha P.J., Sham M.H., Tam P.K.H. and Vanden Berghe P., White paper on guidelines concerning enteric nervous system stem cell therapy for enteric neuropathies, Developmental Biology. 2016, 417(2): 229-251.

Cheng M.H., Tam C.N., Choy K.W., Tsang W.H., Tsang S.L., Pang C.P., Song Y. and Sham M.H., A γA-Crystallin Mouse Mutant Secc with Small Eye, Cataract and Closed Eyelid, PLOS ONE. 2016, 11: e0160691.

HO C.C., QIN T., Wang B., Wong Y.M.E., LIU Y., Hui C.C. and Sham M.H., Sufu controls the proliferation and differentiation of cochlear prosensory progenitors, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

HO C.C., QIN T., Wang B., Wong Y.M.E., LIU Y., Hui C.C. and Sham M.H., Sufu regulates the proliferation and differentiation of hair cell progenitors in mammalian cochlea, 18th International Congress of Developmental Biology. 2017.

LI Z., LEUNG C., SIT H.M. and Sham M.H., Defective cell adhesion and cell migration in Sox10 mutant neural crest, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

LI Z., LEUNG C., SIT H.M. and Sham M.H., Dysregulation of cell adhesion and cell migration genes in Sox10 mutant neural crest, 18th International Congress of Developmental Biology. 2017.

LIU Y., Wang B., Wong Y.M.E., Tsang S.L., HO C.C., Hui C.C. and Sham M.H., The roles of Irx3 and Irx5 in inner ear neurosensory patterning, 18th International Congress of Developmental Biology. 2017.

LIU Y., Wang B., Wong Y.M.E., Tsang S.L., HO C.C., Hui C.C. and Sham M.H., The roles of Irx3 and Irx5 in inner ear neurosensory patterning, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

PAN W., HO H.H., Hui C.C. and Sham M.H., Regulation of mammalian hindbrain neural progenitor proliferation and differentiation by Suppressor of fused and β-catenin, 18th International Congress of Developmental Biology. 2017.

PAN W., HOR H.H.C., Hui C.C. and Sham M.H., Suppressor of fused regulates neural progenitor cell cycle progression during mammalian hindbrain neurogenesis, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

WANG L., ZHANG H., Wong Y.M.E. and Sham M.H., The role of Notch signalling during mouse craniofacial development, 18th International Congress of Developmental Biology. 2017.

WANG L., Zhang H. and Sham M.H., The role of Notch signalling during mouse pharyngeal arch development, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Wang Y., Wu M.H., Cheung M.P.L., Sham M.H., Haruhiko A., Chan D., Cheah K.S.E. and Cheung M.C.H., Reprogramming of Dermal Fibroblasts into Osteo-Chondrogenic Cells with Elevated Osteogenic Potency by Defined Transcription Factors, Stem Cell Reports. 2017, 8: 1587-1599.

Wong Y.M.E. and Sham M.H., The roles of Hedgehog receptors Cdo and Boc in controlling cochlear hair cell formation, Gordon Research Conference Auditory System 2016 in Bates College, Maine, USA, 10- 15 July 2016. 2016.

Wong Y.M.E., LIANG Y., LIU Y. and Sham M.H., The roles of Hedgehog receptors Cdo and Boc in controlling cochlear hair cell formation, Gordon Research Conference: Auditory System 2016.

Researcher : Sham PC

Project Title:	Replication study of susceptibility genes for colorectal cancer
Investigator(s):	Sham PC, Ho JWC, Cheng KK
Department:	LKS Medical Faculty
Source(s) of Funding:	Small Project Funding
Start Date:	10/2007

Project Title:	Partner State Key Laboratory of Brain and Cognitive Sciences
Investigator(s):	Sham PC, So KF, Tan L
Department:	Centre for Genomic Sciences
Source(s) of Funding:	Matching Fund for State Key Laboratory (SKL)
Start Date:	10/2008

Project Title:	Visiting Research Professors Scheme 2009-10
Investigator(s):	Sham PC
Department:	LKS Medical Faculty
Source(s) of Funding:	Visiting Research Professors Scheme
Start Date:	09/2009

Project Title:	Genomics
Investigator(s):	Sham PC, Chin FYL, Leung FCC
Department:	LKS Medical Faculty
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	06/2013

Project Title:	Cross Cultural Differences in Biased Cognition
Investigator(s):	Sham PC, Chen EYH, Toulopoulou T
Department:	LKS Medical Faculty
Source(s) of Funding:	ESRC/RGC Joint Research Scheme
Start Date:	09/2013

Project Title:	Mutational spectrum for dilated cardiomyopathy in Hong Kong
Investigator(s):	Sham PC, Tse HF, Cherny SS, Garcia-Barcelo MM, Tang SM, Li M
Department:	Centre for Genomic Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2014
Completion Date:	03/2017

Project Title:	A novel computational framework to identify transcription factor-DNA interaction for cancer genomics
Investigator(s):	Sham PC, Yao KM, Wong MP, Wang JJ
Department:	LKS Medical Faculty
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	08/2014

Project Title:	Schizophrenia-related de novo and compound heterozygous mutations
Investigator(s):	Sham PC, Chen EYH, Chang WC, Chan KW, Lee HME, Cherny SS, Li M
Department:	LKS Medical Faculty
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2015

Project Title:	Method and software tool for estimating and dissecting the heritability of complex diseases
Investigator(s):	Sham PC, Cherny SS, Li M
Department:	LKS Medical Faculty
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2015

Project Title:	Establishment of Third Generation Sequencing Core Facility
Investigator(s):	Sham PC, Leung SY, Peiris JSM, Poon LML, Woo PCY, Yuen KY
Department:	LKS Medical Faculty
Source(s) of Funding:	Collaborative Research Fund (CRF) - Major Equipment Project
Start Date:	04/2017

List of Research Outputs

GAO X., XU H., Ho J.C.M., Chan S.H., Sham P.C., Xiao Z., Lee V.H.F., WANG S., Yam J.W.P. and Wong M.P., Uncovering Resistant Genes in EGFR-mutated Lung Adenocarcinomas Prior to Targeted Therapy, Health Research Symposium 2017. Hong Kong, 2017.

QIN Y., Ng R.K., Ng T.W., Tong K.K., Au Y.K., Niu B., Tan Z., Yip M.S., Wang J.J., Sham P.C. and Cheah K.S.E., Genome-wide identification of active enhancers in the developing mouse nucleus pulposus, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

YIP S.H., Wang P., KOCHER J.P., Sham P.C. and Wang J.J., Linnorm: Improved statistical analysis for single cell RNA-seq expression data, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

YU Z., TANG L.F., WANG J., Bao S., SHIEH J.T., LEUNG A.W.L., Gao F., ZHANG Z., WONG S.Y.Y., HUI A.L.C., Dung W.F., ZHANG Z., Fan Y., Wong S.M., Sham P.C., AZHAR A., KWOK P.Y., TAM P.P.L., Lian Q. and Cheah K.S.E., Hnrnpa1 Mutations Cause Congenital Heart Defects, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : Shea GKH

List of Research Outputs

Tsui Y.P., Mun K.L., Chan Y.S., Shum D.K.Y. and Shea G.K.H., Hypoxic preconditioning of marrow-derived progenitor cells as a source for the generation of mature Schwann cells, J. Visualized Experiments. 2017, 124.

Researcher : Shi L

List of Research Outputs

Shi L., Yu B., Cai C.H. and Huang J., Angiogenic inhibitors delivered by the type III secretion system of tumor-targeting Salmonella typhimurium safely shrink tumors in mice, AMB Express. 2016, 6.

Researcher : Shiu SYW

Project Title:	Investigating potential signaling interactions between melatonin MT1 receptor and ‎melatonin-related GPR50 receptor, and profiling melatonin-induced genome-wide ‎transcriptional changes in prostate cancer ‎
Investigator(s):	Shiu SYW
Department:	Physiology
Source(s) of Funding:	Small Project Funding
Start Date:	05/2014
Completion Date:	11/2016

Project Title:	Exploring melatonin receptor signaling in human retinal pigment epithelial cells
Investigator(s):	Shiu SYW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Small Project Funding
Start Date:	04/2015

List of Research Outputs

Liu V.W.S., Yao W.L., Tam C.W., Yao K.M. and Shiu S.Y.W., Melatonin Inhibits Androgen Receptor Splice Variant-7 (AR-V7)-Induced Nuclear Factor-Kappa B (NF-κB) Activation and NF-κB Activator-Induced AR-V7 Expression in Prostate Cancer Cells: Potential Implications for the Use of Melatonin in Castration-Resistant Prostate Cancer (CRPC) Therapy., Int. J. Mol. Sci.. 2017, 18(6): pii: E1130.

Researcher : Shum DKY

Project Title:	30th Annual Conference of Society for Neuroscience Effects of Chondroitin Sulfate Supplements on Regeneration of Bridged Sciatic Nerves
Investigator(s):	Shum DKY
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2000

Project Title:	31st Annual Meeting of Society for Neuroscience Expression of Chondroitin 6-sulfotransferase mRNA and the Sulfation Product in Post-crush Sciatic Nerves of Adult Rats
Investigator(s):	Shum DKY
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2001

Project Title:	Expression of heparanase in the injured spinal cord
Investigator(s):	Shum DKY
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Project Title:	33rd Annual Conference of the Society for Neuroscience Spatiotemporal Expression of Chondroitin 6-Sulfotransferase (C6ST) In Regeneration of Crush-injured Sciatic Nerves of Adult Rats C6ST Expression in Sciatic Nerve Explant Culture of Adult Rats
Investigator(s):	Shum DKY
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2003

Project Title:	Expression of chondroitin sulfotransferases in the injured spinal cord
Investigator(s):	Shum DKY
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Project Title:	Proteoglycans in Signaling Heparan Sulfate/Syndecan-1 Modulates the Balance between Proteinase and Anti-Proteinase in Bronchiectasis
Investigator(s):	Shum DKY
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2005

Project Title:	From bone marrow stromal cells to Schwann cells – in vitro route to specification and utility in re-myelination therapy
Investigator(s):	Shum DKY, Chan YS
Department:	Biochemistry
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2012

List of Research Outputs

CHOW W.H., Cham W.C., Chan Y.S. and Shum D.K.Y., Neuronal and astrocytic proheparanase: Insights on its role in regulating synaptic transmission in central nervous system, Abstracts of 12^th Int’l Symp. on Healthy Aging: Science and Aging – Wellness and Longevity: From Science to Service : 78. [HK. March 11-12, 2017]. 2017.

CHOW W.H., Cham W.C., Chan Y.S. and Shum D.K.Y., Neuronal and astrocytic proheparanase: Roles in regulating synaptic strength in rat hippocampus, Abstracts of 10^th FENS Forum of Neuroscience, 761. [Copenhagen, Denmark. July 2-6, 2016]. 2016.

Cai S., Han L., Ao Q., Chan Y.S. and Shum D.K.Y., Human induced pluripotent stem cell-derived sensory neurons for fate commitment of bone marrow-derived Schwann cells: Implications for re-myelination therapy, Stem Cells Translational Medicine. 2017, 6: 369-381.

Chan Y.S., Botelho F.P., Ma C.W., Shi W. and Shum D.K.Y., Developmental plasticity of brain circuits for navigational behavior. Frontiers in Cellular Neuroscience [14^th Meeting of Asian-Pacific Society for Neurochemistry, Kuala Lumpur August 27-30, 2016. 2016.

Chan Y.S., Tsui Y.P. and Shum D.K.Y., Preservation of Schwann cell identity in vitro through bone morphogenetic protein signaling, Soc. Neuroscience Abstract (USA), 390.05 [San Diego. Nov. 12-16, 2016]. 2016.

Chan Y.S., Ma C.W., Shi W. and Shum D.K.Y., Wiring of functional brain circuits for spatial orienting behavior, [International Conference of Physiological Sciences 2016 Beijing. September 25-28, 2016]. 2016.

Hau W.F., Chan Y.S. and Shum D.K.Y., Sulfation patterns of chondroitins in the rat brainstem during development and vestibular compensation, Abstracts of 10^th FENS Forum of Neuroscience, 1771. [Copenhagen, Denmark. July 2-6, 2016]. 2016.

JIANG Q., Chen W., Shum D.K.Y. and Chan Y.S., Antidepressant Reinstates the Plasticity of Vestibular-mediated Navigation in the Adult, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

JIANG Q., Ma C.W., Shum D.K.Y. and Chan Y.S., Antidepressant reactivates the plasticity of vestibular-dependent navigation in the adult, Soc. Neuroscience Abstract (USA) , 264.14 [San Diego. Nov. 12-16, 2016]. 2016.

JIANG Q., Ma C.W., Shum D.K.Y. and Chan Y.S., Antidepressant reinstates the plasticity of vestibular-mediated navigation in the adult, Abstracts of 12^th Int’l Symp. on Healthy Aging: Science and Aging – Wellness and Longevity: From Science to Service: 61. [HK. March 11-12, 2017]. 2017.

JIANG Y., LAM T.F., Ma C.W., Shum D.K.Y., WANG J.J. and Chan Y.S., Modulatory role of orexin on synaptic transmission in the central vestibular system, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

JIANG Y., Lam T.F.U., Ma C.W., Shum D.K.Y., Wang J.J. and Chan Y.S., Modulatory role of orexin on synaptic transmission in the central vestibular system, Soc. Neuroscience Abstract (USA), 803.04 [San Diego. Nov. 12-16, 2016]. 2016.

JIANG Y., LAM T.F., Ma C.W., Shum D.K.Y., Wang J.J. and Chan Y.S., Orexin regulates synaptic transmission within the rat vestibular nucleus, Abstracts of 12^th Int’l Symp. on Healthy Aging: Science and Aging – Wellness and Longevity: From Science to Service : 64. [HK. March 11-12, 2017]. 2017.

KWAN P.Y., Ma C.W., Chan Y.S. and Shum D.K.Y., Role of perineuronal chondroitin sulfates and semaphorin3A in the maturation of the vestibular circuitry, Abstracts of 10^th FENS Forum of Neuroscience, 2349. [Copenhagen, Denmark. July 2-6, 2016]. 2016.

Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Immobilised Chondroitinase ABC Promotes Axonal Regrowth in Lesioned Spinal Cord, 12^th International Symposium on Healthy Aging--Wellness and Longevity: From Science to Service. 2017, P9: 63.

Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Immobilised chondroitinase ABC promotes axonal regrowth in lesioned spinal cord, Abstracts of 12^th Int’l Symp. on Healthy Aging: Science and Aging Wellness and Longevity: From Science to Service : 63. [HK. March 11-12, 2017]. 2017.

LAM T.F., Ma C.W., Shum D.K.Y., Wang J.J. and Chan Y.S., Behavioral expression of orexin-modulated transmission in the vestibular nucleus of postnatal rats, Neuroscience 2016 of the Society for the Neurosciences. 2016.

LI Z., Chan Y.S. and Shum D.K.Y., Activity regulated neuronal trafficking of heparanase 1, Abstracts of 12^th Int’l Symp. on Healthy Aging: Science and Aging – Wellness and Longevity: From Science to Service : 50. [HK. March 11-12, 2017]. 2017.

LI Z., Chan Y.S. and Shum D.K.Y., Trafficking of Heparanase 1 is regulated by neuronal activity during homeostatic synaptic plasticity, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Lam T.F.U., Ma C.W., Shum D.K.Y., Wang J.J. and Chan Y.S., Behavioral expression of orexin-modulated transmission in the vestibular nucleus of postnatal rats, Soc. Neuroscience Abstract (USA), 803.09 [San Diego. Nov. 12-16, 2016]. 2016.

Shum D.K.Y., KWAN P.Y., Ma C.W. and Chan Y.S., The regulatory roles of perineuronal semaphorin 3A and chondroitin sulfates on the developing vestibular circuitry, Soc. Neuroscience Abstract (USA), 677.17 [San Diego. Nov. 12-16, 2016]. 2016.

Shum D.K.Y., Tsui Y.P., Cai S. and Chan Y.S., iPSC-derived sensory neurons for fate commitment of bone marrow-derived Schwann cells: Implication for re-myelination therapy, Frontiers in Cellular Neuroscience [14^th Meeting of Asian Pacific Society for Neurochemistry. Kuala Lumpur. August 27-30, 2016]. 2016.

Tsui Y.P., Wu L.K., Shum D.K.Y. and Chan Y.S., Cell therapy for CNS myelin disorders: Derivation of myelin-forming oligodendrocyte precursors from neural progenitors harbored by adult bone marrow stromal cells, Abstracts of 12^th Int’l Symp. on Healthy Aging: Science and Aging – Wellness and Longevity: From Science to Service: 81. [HK. March 11-12, 2017]. 2017.

Tsui Y.P., Mun K.L., Chan Y.S., Shum D.K.Y. and Shea G.K.H., Hypoxic preconditioning of marrow-derived progenitor cells as a source for the generation of mature Schwann cells, J. Visualized Experiments. 2017, 124.

Tsui Y.P., Tam K.W., Shum D.K.Y. and Chan Y.S., Schwann cells demonstrated lineage plasticity in culture and acquired oligodendrocyte phenotypes, International Society for Stem Cell Research Annual Meeting 2016.

Wu K.L., Shum D.K.Y. and Chan Y.S., Neuron-astrocyte signaling in perineuronal net formation, Abstracts of 10^th FENS Forum of Neuroscience, 3475. [Copenhagen, Denmark. July 2-6, 2016]. 2016.

Wu L.K., Shum D.K.Y. and Chan Y.S., Neuron-astrocyte signaling In perineuronal net formation, 10^th FENS Forum of Neuroscience (FENS 2016). 2016.

Researcher : So KF

Project Title:	Minimizing neuropsychiatric side-effects of glucocorticoid therapy by antipsychotics and Chinese medicine
Investigator(s):	So KF, Lee TMC, Chang RCC, Ching YP
Department:	Anatomy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	01/2014
Completion Date:	11/2016

Project Title:	Study of gliogenesis and neurochemistry underlying psychomotor retardation induced by chronic stress and the therapeutic approach for motor training in reversing the adverse effects
Investigator(s):	So KF, Wu W, Lee TMC
Department:	Ophthalmology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2015

Project Title:	Potential Role of Adiponectin Signaling in Mediating Physical Exercise-Elicited Hippocampal Neurogenesis and Antidepressive Effects in Stressed Mice
Investigator(s):	So KF, Xu A
Department:	Ophthalmology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2015

List of Research Outputs

CHAN K.C., ZHOU Y., LIU S.S., van der Merwe Y., FAN S., HUNG K., Chung S.K., Wu W., So K.F. and Wu E.X., Longitudinal Assessments of Normal and Perilesional Tissues in Focal Brain Ischemia and Partial Optic Nerve Injury with Manganese-enhanced MRI, Scientific Reports. 2017, 7: 43124.

Researcher : Song Y

Project Title:	A Randomized Controlled Trial of the Therapeutic Effects of Tai Chi and Mahjong on Older Persons With Cognitive Impairment
Investigator(s):	Song Y
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2008

Project Title:	Investigation on Pax6 regulation of neuronal apoptosis in Alzheimer’s disease
Investigator(s):	Song Y
Department:	School of Biomedical Sciences
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2013

Project Title:	Study of Population Specific Linkage Disequilibrium (LD) Patterns of Human Major Histocompatibility Complex (MHC) Region for Cancers, Infectious and Autoimmunity Diseases in Southern Chinese
Investigator(s):	Song Y, Sham PC, Fan Y
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2014
Completion Date:	07/2017

Project Title:	Modeling host susceptibility to influenza H7N9 virus in inbred mice: a pilot study
Investigator(s):	Song Y, Yeung ML, Kok KH
Department:	School of Biomedical Sciences
Source(s) of Funding:	Commissioned Studies on Emerging Influenza A Viruses with Epidemic Potential
Start Date:	10/2014
Completion Date:	06/2017

Project Title:	Targeted sequencing to identify of genes on candidate loci causing Adolescent Idiopathic Scoliosis (AIS)
Investigator(s):	Song Y, Luk KDK, Chan D, Sham PC, Cheung KMC
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2015
Completion Date:	03/2017

Project Title:	Study of the pathogenic mechanisms of Hnrnpa1 in congenital heart defects (CHD)
Investigator(s):	Song Y, Lian Q, Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016

Project Title:	Investigation of the roles of HNRNPA1 in the maintenance of motor neurons
Investigator(s):	Song Y, Cheung MCH, Ho WL, Huen MSY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2016

Project Title:	Alzheimer's Association International Conference (AAIC); A role of PTPN21 in neuron survival and degeneration
Investigator(s):	Song Y
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2016
Completion Date:	07/2016

Project Title:	Mapping a locus on chromosome 17 controlling endoplasmic reticulum stress and defence response in mice
Investigator(s):	Song Y, Yeung ML, Bao S
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2017

List of Research Outputs

Chen L.P., Fan Y., Kao P.Y., Ho D.T., Ha C.T.J., Chu L.W. and Song Y., Genetic Polymorphisms in Estrogen Metabolic Pathway Associated with Risks of Alzheimer's Disease: Evidence from a Southern Chinese Population, J Am Geriatr Soc.. 2017, 65(2): 332-339.

Cheng M.H., Tam C.N., Choy K.W., Tsang W.H., Tsang S.L., Pang C.P., Song Y. and Sham M.H., A γA-Crystallin Mouse Mutant Secc with Small Eye, Cataract and Closed Eyelid, PLOS ONE. 2016, 11: e0160691.

Fan Y. and Song Y., PyHLA: tests for the association between HLA alleles and diseases, BMC Bioinformatics. 2017, 18(1): 90.

Li M., LI J., Li J., Pan Z., HSU S.J., Liu D., Zhan X., Wang J.J., Song Y. and Sham P.C., Robust and rapid algorithms facilitate large-scale whole genome sequencing downstream analysis in an integrative framework, Nucleic Acids Res. 2017, 45(9): e75.

Song Y., Chen F., George-Hyslop P. and Plani-Lam J.H.C., A role of PTPN21 in neuron survival and degeneration, Alzheimer's Association International Conference (AAIC). 2016.

Researcher : Sy MH

Project Title:	Regulation of Microcephalin (MCPH1) by the Herpes Simplex Virus Type 1 Regulatory Protein ICP0
Investigator(s):	Sy MH, Huen MSY
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	05/2013

Project Title:	The role of DNA Damage and Repair Signaling in Hepatocarcinogenesis
Investigator(s):	Sy MH, Huen MSY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	08/2015

List of Research Outputs

GUO Y., AN L., NG H.M., Sy M.H. and Huen M.S.Y., An E2-guided E3 Screen Identifies the RNF17-UBE2U Pair as Regulator of the Radiosensitivity, Immunodeficiency, Dysmorphic Features, and Learning Difficulties (RIDDLE) Syndrome Protein RNF168., Journal Of Biological Chemistry. 2017, 292: 967-978.

Researcher : TAM SW

List of Research Outputs

TAM S.W., Lau K.W.W., Yeung P.K.K., Law A.C.K. and Chung S.K., Endothelin-1 induced cofilin rod formation in hippocampal neurons via endothelin type B receptor and NADPH oxidase-mediated oxidative stress pathway, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : TAN ZKS

List of Research Outputs

Lim L.W., Shrestha S., Or Y.Z., TAN Z.K.S., Chung H.H., Sun Y.A.N.G., Lim C.H.E.W. .L.E.N.G., MUHAMMAD SHARAFUDDIN BIN M.K., Lufkin T. and Lin V.C.L., Tetratricopeptide repeat domain 9A modulates anxiety-like behavior in female mice , Scientific Reports. 2016, 37568.

TAN Z.K.S. and Lim L.W., Brain pacemaker and memory enhancement: Investigation of neural and molecular mechanisms in the aged brain. , 50th Malaysia-Singapore Congress of Medicine & the 3rd Academy of Medicine Malaysia-Academy of Medicine Singapore-Hong Kong Academy of Medicine Tripartite Congress incorporating the 1st Emergency Medicine Annual Scientific Meeting. Malaysia.. Malaysian Journal of Emergency Medicine., 2016.

TAN Z.K.S., MUHAMMAD SHARAFUDDIN BIN M.K., Hescham S., Blokland A., Temel Y. and Lim L.W., Deep brain stimulation of the entorhinal cortex or perifornical area in an aged animal model transiently restores memory function., The Francis Crick Symposium, Suzhou, China. 2017.

TAN Z.K.S., Lim L.W., Shrestha S., OR Y.Z., Chung H.H., Sun Y., Lim C.L., MUHAMMAD SHARAFUDDIN BIN M.K., Lufkin T. and Lin V.C.L., Tetratricopeptide repeat domain 9A modulates anxiety-like behavior in female mice, 4th International Anatomical Sciences & Cell Biology Conference, Hong Kong.. 2016.

Researcher : TANG SLM

List of Research Outputs

Cheung Y.W., SHIU C.C., FRASER L.A., LIANG S., Dirkzwager R.M., Kinghorn A.B., TANG S.L.M. and Tanner J.A., Aptamer-mediated biosensing: from malaria diagnosis to DNA nanostructure dynamics, 5th International Conference on Bio-Sensing Technology. 2017.

Cheung Y.W., SHIU C.C., Wong W.C., TANG S.L.M., DIRKZWAGER R.M., LIANG S., KINGHORN A.B., FRASER L.A. and Tanner J.A., From DNA aptamer structure to splitting for use in DNA nanotweezers, Oligo 2017 Oxford: Antisense & Therapeutic Nucleic Acids. 2017.

KINGHORN A.B., DIRKZWAGER R.M., LIANG S., Cheung Y.W., FRASER L.A., SHIU C.C., TANG S.L.M. and Tanner J.A., Aptamer Affinity Maturation by Resampling and Microarray Selection, Analytical Chemistry. American Chemical Society, 2016, 88: 6981-6985.

SHIU C.C., Cheung Y.W., DIRKZWAGER R.M., LIANG S., Kinghorn A.B., FRASER L.A., TANG S.L.M. and Tanner J.A., A split aptamer can facilitate protein recognition in DNA nanotweezers, Aptamers 2017, 4th Oxford Symposium on Aptamers. 2017.

SHIU C.C., Cheung Y.W., LIANG S., Kinghorn A.B., LIANG S., TANG S.L.M. and Tanner J.A., An Aptamer-Mediated DNA Nano-Switch, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

SHIU C.C., Cheung Y.W., DIRKZWAGER R.M., LIANG S., Kinghorn A.B., FRASER L.A., TANG S.L.M. and Tanner J.A., Aptamer-Mediated Protein Molecular Recognition Driving a DNA Tweezer Nanomachine, Advanced Biosystems. 2017, 1: 1600006.

SHIU C.C., Cheung Y.W., Dirkzwager R.M., LIANG S., Kinghorn A.B., FRASER L.A., Tang S.L.M. and Tanner J.A., DNA Tweezer Nanomachine Mediated by Heterogeneous Recognition, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

SHIU C.C., TANG S.L.M., DIRKZWAGER R.M., LIANG S., Kinghorn A.B., Cheung Y.W., FRASER L.A., Godonoga M., Heddle J.G. and Tanner J.A., Protein driven aptamer toehold switches integrated into DNA origami nanostructures, Oligo 2017 Oxford: Antisense & Therapeutic Nucleic Acids. 2017.

TANG S.L.M., Design, Construction and Characterization of Aptamer-functionalized DNA Origami for Malaria Diagnosis (MPhil thesis), The University of Hong Kong. 2016.

Researcher : TANG WC

List of Research Outputs

TANG W.C., Tsang C.M., Jones G.E. and Tsao G.S.W., Formation of invadopodia in LMP1-expressing nasopharyngeal epithelial cells, 17th International Symposium on EBV and associated diseases. 2016.

Tsang C.M., TANG W.C., Jones G.E. and Tsao G.S.W., The roles of tumor-associated macrophages in potentiating the invasiveness of EBV-infected nasopharyngeal epithelial cells, 17th International Symposium on EBV and associated diseases. 2016.

Researcher : TANG X

List of Research Outputs

TANG X., A positive feedback loop between PIM2 and TNFa contributes to hepatocellular carcinoma tumorigenesis and progression (PhD Thesis), The University of Hong Kong. 2016.

Researcher : TONG CKB

List of Research Outputs

DONG R., Tong C.K.B. and Cheung K.H., Impaired Ca2+ Homeostasis in Lysosome Caused by FAD-linked Presenilin-1 Mutation is Responsible for Autophagy Defection in Familial Alzheimer’s Disease, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

DONG R., TONG C.K.B. and Cheung K.H., Lysosomal Ca2+ disruption induces autophagy impairment in familial Alzheimer’s disease, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

TONG C.K.B., LEE S.K., CHENG W.H., Lai K.O., Foskett J.K. and Cheung K.H., Familial Alzheimers disease-associated presenilin 1 mutants promote γ-secretase cleavage of STIM1 to impair store-operated Ca2+ entry, Science Signaling. 2016, 9: ra89.

TONG C.K.B., Mechanism of Deranged Capacitative Calcium Entry in Neurons and Its Role in Neuronal Spine Stability (PhD Thesis), The University of Hong Kong. 2017.

Researcher : Tai CP

List of Research Outputs

Tai C.P., Cheung M.C.H., Huang Y.H., Jauch R., Bronner M.E. and Cheah K.S.E., SOXE neofunctionalization and elaboration of the neural crest during chordate evolution, Scientific Reports. 2016, 6: 34964.

Researcher : Tam KW

List of Research Outputs

Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Immobilised Chondroitinase ABC Promotes Axonal Regrowth in Lesioned Spinal Cord, 12^th International Symposium on Healthy Aging--Wellness and Longevity: From Science to Service. 2017, P9: 63.

Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Immobilised chondroitinase ABC promotes axonal regrowth in lesioned spinal cord, Abstracts of 12^th Int’l Symp. on Healthy Aging: Science and Aging Wellness and Longevity: From Science to Service : 63. [HK. March 11-12, 2017]. 2017.

Tsui Y.P., Tam K.W., Shum D.K.Y. and Chan Y.S., Schwann cells demonstrated lineage plasticity in culture and acquired oligodendrocyte phenotypes, International Society for Stem Cell Research Annual Meeting 2016.

Researcher : Tam V

Project Title:	Understanding the role of clusterin in intervertebral disc degeneration
Investigator(s):	Tam V, Chan D
Department:	School of Biomedical Sciences
Source(s) of Funding:	Small Project Funding
Start Date:	06/2015

Researcher : Tan Z

Project Title:	Cartilage Biology & Pathology Gordon Research Conference:Understanding Biology to Achieve Better Cartilage Health; Synergistic co-regulation and competition underlies a SOX9-GLI- FOXA phasic transcriptional network that coordinates growth plate chondrocyte differentiation
Investigator(s):	Tan Z
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2017
Completion Date:	04/2017

List of Research Outputs

QIN Y., Ng R.K., Ng T.W., Tong K.K., Au Y.K., Niu B., Tan Z., Yip M.S., Wang J.J., Sham P.C. and Cheah K.S.E., Genome-wide identification of active enhancers in the developing mouse nucleus pulposus, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

SO K.H., Kudelko M.A., Tan Z., Wang C., Chan W.C.W., Tsang K.Y., Cheah K.S.E. and Chan D., FGF21 Up-Regulates Glycolytic Proteins for Hypertrophic Chondrocyte Survival under ER Stress, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : Tang HC

List of Research Outputs

Li S.K., Tang H.C., Lau P.Y., Zhou Y. and Ching Y.P., HBx oncoprotein induces chromosome instability in hepatocarcinogenesis via dysregulation of putative tumor suppressor, TAX1BP2, Health Research Symposium 2017.

Researcher : Tang HMV

List of Research Outputs

CHENG Y., GAO W., Tang H.M.V. and Jin D., β-TrCP targets liver-enriched and membrane-bound transcription factor CREB-H for ubiquitination and degradation., 16th International Union of Biochemistry and Molecular Biology (IUBMB) Conference: Signaling Pathways in Development, Diseases and Aging.. Vancouver, Canada, 2016.

Deng J., Kong K.Y., Gao W., Tang H.M.V., CHAUDHARY V., CHENG Y., Zhou J., Chan C.P., Wong D.K.H., Yuen R.M.F. and Jin D., Interplay between SIRT1 and hepatitis B virus X protein in the activation of viral transcription, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 2017, 1860: 491-501.

Deng J., Kong K.Y., GAO W., Tang H.M.V., Chan C.P. and Jin D., Sirtuins are potent activators of hepatitis B virus transcription., 2016 International HBV Meeting.. Seoul, Korea, 2016.

GAO W., Tang H.M.V., CHENG Y., WANG P. and Jin D., Regulation of ubiquitination and degradation of CRTC1 transcriptional coactivator by salt-inducible kinase SIK1., 16th International Union of Biochemistry and Molecular Biology (IUBMB) Conference: Signaling Pathways in Development, Diseases and Aging.. Vancouver, Canada, 2016.

Kong K.Y., Deng J., GAO W., Tang H.M.V., CHAUDHARY V., CHENG Y., Wong D.K.H., Yuen R.M.F., Ma S.K.Y., Chan C.P. and Jin D., PRMT5 protein arginine methyltransferase activates hepatitis B virus transcription., 2016 International HBV Meeting.. Seoul, Korea, 2016.

Researcher : Tang SLM

List of Research Outputs

TANG S.L.M., Design, Construction and Characterization of Aptamer-functionalized DNA Origami for Malaria Diagnosis (MPhil thesis), The University of Hong Kong. 2016.

Researcher : Tanner JA

Project Title:	Comparative Characterization of the Two Polyphosphate Kinases of M. tuberculosis
Investigator(s):	Tanner JA
Department:	Biochemistry
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	02/2005

Project Title:	3-D Printed Aptamer-Enabled Diagnostic Dominoes for Malaria
Investigator(s):	Tanner JA
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014
Completion Date:	01/2018

Project Title:	Aptamer-mediated Point-of-Care Diagnostics (CRF)
Investigator(s):	Tanner JA
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Funding for Incubating Group-based Collaborative Research Projects
Start Date:	01/2015
Completion Date:	12/2016

Project Title:	DNA origami interfaced with aptamer-mediated molecular recognition for integrated modular diagnostics
Investigator(s):	Tanner JA, Watt RM
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	DNA Display SELEX ??a new approach to evolve fluorescent tools to image RNA in living cells
Investigator(s):	Tanner JA, Shum HC
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016

Project Title:	Development of an aptamer-based sensor for monitoring luteinizing hormone pulsatility
Investigator(s):	Tanner JA, Li RHW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2016

Project Title:	Outstanding Young Researcher Award 2015-16
Investigator(s):	Tanner JA
Department:	School of Biomedical Sciences
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	11/2016

Project Title:	Expanding the functional repertoire of nucleic acid aptamers by fluorescence-activated droplet sorting
Investigator(s):	Tanner JA, Shum HC
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2017

Project Title:	Using unnatural base pairs from an expanded genetic code to achieve nested chain terminating PCR for applications in highly multiplexed DNA amplification
Investigator(s):	Tanner JA, Kinghorn AB
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2017

Project Title:	5th International Conference on Biosensing Technology; Aptamer-mediated biosensing: from malaria diagnosis to DNA nanostructure dynamics
Investigator(s):	Tanner JA
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2017
Completion Date:	05/2017

List of Research Outputs

BHUYAN S.K., Kinghorn A.B., TANG Y.H., Shum H.C. and Tanner J.A., A high throughput approach for discovery of catalytic nucleic acids, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Cheung Y.W., SHIU C.C., FRASER L.A., LIANG S., Dirkzwager R.M., Kinghorn A.B., TANG S.L.M. and Tanner J.A., Aptamer-mediated biosensing: from malaria diagnosis to DNA nanostructure dynamics, 5th International Conference on Bio-Sensing Technology. 2017.

Cheung Y.W., DIRKZWAGER R.M., FRASER L.A., Richards J.S. and Tanner J.A., DNA aptamer targeting Plasmodium falciparum histidine rich protein 2: Development of aptamer—antibody sandwich assay for malaria rapid diagnosis, International Congress for Tropical Medicine and Malaria. 2016.

Cheung Y.W. and Tanner J.A., Development of sandwich aptamer-based lateral flow strip tests for Plasmodium specific malaria diagnosis, 4th Oxford Symposium on Aptamers. 2017.

Cheung Y.W., SHIU C.C., Wong W.C., TANG S.L.M., DIRKZWAGER R.M., LIANG S., KINGHORN A.B., FRASER L.A. and Tanner J.A., From DNA aptamer structure to splitting for use in DNA nanotweezers, Oligo 2017 Oxford: Antisense & Therapeutic Nucleic Acids. 2017.

FRASER L.A., Kinghorn A.B., Dirkzwager R.M., Cheung Y.W., Richards J. and Tanner J.A., 3D Printed Microfluidics for Point of Care Malaria Diagnosis, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

KHONG M.L., LI L., SOLESIO M.E.T., LANG Y.P., PAVLOV E. and Tanner J.A., Inorganic Polyphosphate Influences Cyclophilin B-Mediated Protein Folding In Osteoblasts, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

KHONG M.L., Li L. and Tanner J.A., Inorganic polyphosphate is a fundamental molecule in osteoblasts: from interactions to functions, 41st Annual Conference of the Malaysian Society for Biochemistry & Molecular Biology, Kuala Lumpur, Malaysia. 2016.

KHONG M.L., Li L., Lang C.Y.P. and Tanner J.A., Inorganic polyphosphate – a mediator of protein folding in osteoblasts via interaction with cyclophilin B, American Society for Biochemistry and Molecular Biology (ASBMB) Annual Meeting. 2017.

KHONG M.L., Li L., Lang C.Y.P. and Tanner J.A., Translating Polyphosphate-Cyclophilin B Interaction to an Understanding of Polyphosphate’s Role in Protein Folding, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

KINGHORN A.B., DIRKZWAGER R.M., LIANG S., Cheung Y.W., FRASER L.A., SHIU C.C., TANG S.L.M. and Tanner J.A., Aptamer Affinity Maturation by Resampling and Microarray Selection, Analytical Chemistry. American Chemical Society, 2016, 88: 6981-6985.

Lang C.Y.P., KHONG M.L., Li L. and Tanner J.A., Elucidating human cyclophilin B properties as a polyphosphate-binding protein, National Collegiate Research Conference, Harvard University, Boston. 2017.

Lui E.L.H., AO K.L., Li L., KHONG M.L. and Tanner J.A., Inorganic polyphosphate triggers upregulation of interleukin 11 in human osteoblast-like SaOS-2 cells, Biochemical and Biophysical Research Communications. 2016, 479: 766-771.

Miranda G.F., Feng L., SHIU C.C., DIRKZWAGER R.M., Tanner J.A., Schöning M.J., Offenhäusser A. and Mayer D., Aptamer-based electrochemical biosensor for highly sensitive and selective malaria detection, 1st International Symposium for Biomedical Research. 2017.

SHIU C.C., Cheung Y.W., DIRKZWAGER R.M., LIANG S., Kinghorn A.B., FRASER L.A., TANG S.L.M. and Tanner J.A., A split aptamer can facilitate protein recognition in DNA nanotweezers, Aptamers 2017, 4th Oxford Symposium on Aptamers. 2017.

SHIU C.C., Cheung Y.W., LIANG S., Kinghorn A.B., LIANG S., TANG S.L.M. and Tanner J.A., An Aptamer-Mediated DNA Nano-Switch, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

SHIU C.C., Cheung Y.W., DIRKZWAGER R.M., LIANG S., Kinghorn A.B., FRASER L.A., TANG S.L.M. and Tanner J.A., Aptamer-Mediated Protein Molecular Recognition Driving a DNA Tweezer Nanomachine, Advanced Biosystems. 2017, 1: 1600006.

SHIU C.C., Cheung Y.W., Dirkzwager R.M., LIANG S., Kinghorn A.B., FRASER L.A., Tang S.L.M. and Tanner J.A., DNA Tweezer Nanomachine Mediated by Heterogeneous Recognition, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

SHIU C.C., TANG S.L.M., DIRKZWAGER R.M., LIANG S., Kinghorn A.B., Cheung Y.W., FRASER L.A., Godonoga M., Heddle J.G. and Tanner J.A., Protein driven aptamer toehold switches integrated into DNA origami nanostructures, Oligo 2017 Oxford: Antisense & Therapeutic Nucleic Acids. 2017.

Tanner J.A., Aptamer-enabled diagnostics for malaria, The 1st Peking University-Hong Kong University Joint Symposium on Chemical Biology. 2016.

Tanner J.A., Aptamers for malaria diagnosis, Aptamers 2017, 4th Oxford Symposium on Aptamers. 2017.

Tanner J.A., Aptamers in DNA nanostructures as molecular sensing modules, Oligo 2017 Oxford: Antisense & Therapeutic Nucleic Acids. 2017.

Tanner J.A., Assessing collaborative learning outcomes in high-stakes tests: design and evaluation of a two-stage examination, New Perspectives in Science Education. 2017.

Tanner J.A., Collaborative examinations in biomedical sciences: implementation and evaluation, Frontiers in Medical and Health Sciences Education on Promoting Excellence in Assessment, Hong Kong. 2016.

Tanner J.A. and KINGHORN A.B., DNA DISPLAY AND METHODS THEREOF, WIPO Patent WO/2016/134521. 2016, CN2015/073350.

Tanner J.A., Design, implementation and evaluation of a two-stage examination to enhance student collaboration within a biomedical sciences course, 14th Asia Pacific Medical Education Conference – from Globalisation of Education to Global Healthcare. 2017.

Tanner J.A., Engineering nucleic acid nanostructures using aptamers, Symposium on Engineering Complex Genetic Systems: Approaches and Applications. 2017.

Tanner J.A., Mimicking scholarly peer review within a biomedical sciences course to strengthen student learning, critical thinking, collaboration and feedback, 14th Asia Pacific Medical Education Conference – from Globalisation of Education to Global Healthcare. 2017.

Tanner J.A., Progress in aptamer-mediated malaria diagnosis, Aptamers 2016, 3rd Oxford Symposium on Aptamers. 2017.

Wang W.X., Cheung Y.W., DIRKZWAGER R.M., Wong W.C., Tanner J.A., Li H.W. and Wu Y., Specific and sensitive detection of Plasmodium falciparum lactate dehydrogenase by DNA-scaffolded silver nanoclusters combined with an aptamer, The Analyst. 2017, 142: 800-807.

ZHOU N., ZHAO Y.F., AGNESE C., Tanner J.A., ADRIAN D. and Huang J., Synthetic Multicellular Systems for Spontaneous Pattern Formation, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : Tipoe GL

Project Title:	23rd Conference of the Asian Pacific Association for the Study of the Liver (APASL); Polysaccharides from Lycium barbarum attenuates hepatic steatosis, fibrosis and inflammation in non-alcoholic liver diseases (NAFLD) rat model
Investigator(s):	Tipoe GL
Department:	Anatomy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2013

Project Title:	The regulation of cylcooxygenase-1 in a carbon tetrachloride induced acute liver injury animal model
Investigator(s):	Tipoe GL
Department:	School of Biomedical Sciences
Source(s) of Funding:	Small Project Funding
Start Date:	04/2015
Completion Date:	06/2017

Project Title:	Therapeutic effects of Wolfberry (Lycium barbarum polysaccharides; LBP) in non-alcoholic fatty liver disease (NAFLD) animal models
Investigator(s):	Tipoe GL, So KF
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2015

Project Title:	Novel anti-hepatic cancer properties of garlic-derived SAMC through direct targeting of LRP6/Wnt signaling pathway
Investigator(s):	Tipoe GL
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2016
Completion Date:	07/2017

Project Title:	Defining the protective functional role of cyclooxygenase-1 in acute and chronic liver diseases
Investigator(s):	Tipoe GL, Ching YP
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2016

Project Title:	Mechanisms underlying the ameliorative effects of chronic aerobic exercise in non-alcoholic steatohepatitis
Investigator(s):	Tipoe GL
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2017

List of Research Outputs

Guo R., Lin B., PAN J., Liong E.C., Xu A., Youdim M., Fung M.L., So K.F. and Tipoe G.L., Inhibition of caspase-9 aggravates acute liver injury through suppression of cytoprotective autophage, Scientific Reports. 2016, 6: 32447.

Hung M.W., Yeung H.M., Lau C.F., Poon A.M.S., Tipoe G.L. and Fung M.L., Melatonin attenuates pulmonary hypertension in chronically hypoxic rats, International Journal of Molecular Sciences. 2017, 18(6): 1125.

LAM C.S., Tipoe G.L., Wong K.C., Youdim M.B.H. and Fung M.L., M30 Antagonizes Indoleamine 2,3-Dioxygenase Activation and Neurodegeneration Induced by Corticosterone in the Hippocampus, In: Kenji Hashimoto, Chiba Daigaku, PLoS ONE. 2016.

Lam C.S., LI J., Tipoe G.L., Youdim M.B.H. and Fung M.L., Monoamine oxidase A upregulated by chronic intermittent hypoxia activates indoleamine 2,3-dioxygenase and neurodegeneration, PLoS One . 2017, 12(6): e0177940.

Lam C.S., Tipoe G.L., Wong J.K.C. and Fung M.L., Neuroprotective effect of multifunctional drug M30 against depressive-like behavior induced by hypercortisolemia in rats. The 30^th World Congress of the International College of Neuropsychopharmacology. Seoul, International Journal of Neuropsychopharmacology. 2016, 19, Issue Suppl. (1): 47-48.

Researcher : Tong CKB

List of Research Outputs

TONG C.K.B., Mechanism of Deranged Capacitative Calcium Entry in Neurons and Its Role in Neuronal Spine Stability (PhD Thesis), The University of Hong Kong. 2017.

Researcher : Tong KK

List of Research Outputs

QIN Y., Ng R.K., Ng T.W., Tong K.K., Au Y.K., Niu B., Tan Z., Yip M.S., Wang J.J., Sham P.C. and Cheah K.S.E., Genome-wide identification of active enhancers in the developing mouse nucleus pulposus, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : Tong M

Project Title:	The clinical and functional significances of glucose transporter, isoform 3 (GLUT3) in CD133+ liver cancer stem cells driven Hepatocellular carcinoma
Investigator(s):	Tong M, Ma SKY
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	03/2015
Completion Date:	08/2016

Project Title:	American Association for Cancer Research Annual Meeting 2017; Targeting ANXA3 in combination with sorafenib for the treatment of hepatocellular carcinoma
Investigator(s):	Tong M
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2017
Completion Date:	04/2017

List of Research Outputs

CHAI S., Ng K.Y., Tong M., Lau Y.T., Lee K.W., Chan K.W., Yuan Y.F., Cheung T.T., Cheung S.T., Wang X., Wong N., Lo C.M., Man K., Guan X. and Ma S.K.Y., Oct4/miR-1246 signaling axis drives Wnt/β-catenin activation in liver cancer stem cells, Hepatology. 2016.

Fung T.M., Ng K.Y., Tong M., CHEN J., Chai S., Chan K.T., Law S.Y.K., Lee N.P.Y., Choi M.Y., Li B., Cheung A., Tsao G.S.W., Qin Y.R., Guan X., Chan K.W. and Ma S.K.Y., Neuropilin-2 promotes tumourigenicity and metastasis in oesophageal squamous cell carcinoma through ERK-MAPK-ETV4-MMP-E-cadherin deregulation, Journal of Pathology. 2016, 239(3): 309-319.

LUK T.C.S., Tong M., Ng K.Y., Guan X. and Ma S.K.Y., Identification of REX1 as a Regulator of Cancer Stemness in CD133+ Liver Cancer Stem Cells by Genome-wide DNA Methylation Analysis, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

Ng K.Y., CHAI S., Tong M., Guan X., Lin C., Ching Y.P., Xie D., Cheng A.S. and Ma S.K.Y., C-terminal truncated hepatitis B virus X protein promotes hepatocellular carcinogenesis through induction of cancer and stem cell-like properties, Oncotarget. 2016.

Researcher : Tsang CM

Project Title:	The protective role of Epstein-Barr virus infection towards starvation-induced apoptosis
Investigator(s):	Tsang CM, Tsao GSW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2014
Completion Date:	10/2017

Project Title:	Potentiation of tumor-associated macrophages (TAMs)-induced invasiveness in EBV-associated nasopharyngeal epithelial cells
Investigator(s):	Tsang CM, Tsao GSW
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2015

Project Title:	The interaction of berberine with chemodrugs for treating EBV-associated carcinomas: the concern for lytic reactivation in affecting the drug efficacy
Investigator(s):	Tsang CM, Tsao GSW, Chiang AKS
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2016

Project Title:	The importance of EBV miR-BARTs in promoting the in vivo tumor growth of nasopharyngeal carcinoma by managing apoptotic responses under metabolic stress
Investigator(s):	Tsang CM, Tsao GSW
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2016

List of Research Outputs

CHAN M.H.M., Lau K.L.K., Lin W., Tsao G.S.W. and Tsang C.M., The interaction of berberine with chemodrugs on Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Jia L.J., Tsang C.M., Yip Y.L., ZHANG J., Deng W. and Tsao G.S.W., Establishment and characterization of immortalized nasopharyngeal epithelial cells with stable infection of Epstein-Barr virus, 4th International Anatomical Sciences & Cell Biology Conference. 2016.

Jia L.J., Tsang C.M., Yip Y.L., Law W.T., ZHANG J., Deng W. and Tsao G.S.W., Establishment and characterization of immortalized nasopharyngeal epithelial cells with stable infection of Epstein-Barr virus, AMPK 2016: New Mechanism and Physiology. 2016.

Jia L.J., ZHANG J., Yip Y.L., Lin W., Jin D., Tsang C.M. and Tsao G.S.W., Hypoxia induces lytic reactivation of Epstein-Barr virus in stable M81-infected nasopharyngeal epithelial cells, Keystone Symposia Conference on Tumor Metabolism: Mechanisms and Targets. 2017.

Sharmila V., Tsao G.S.W., Tsang C.M., Dawson C., Paterson I.C. and Yap L.F., The Role of Transforming Growth Factor-β Signalling in Persistent EBV Infection of Nasopharyngeal Epithelial Cells, 4th International Anatomical Sciences & Cell Biology Conference. 2016.

TANG W.C., Tsang C.M., Jones G.E. and Tsao G.S.W., Formation of invadopodia in LMP1-expressing nasopharyngeal epithelial cells, 17th International Symposium on EBV and associated diseases. 2016.

Tsang C.M., TANG W.C., Jones G.E. and Tsao G.S.W., The roles of tumor-associated macrophages in potentiating the invasiveness of EBV-infected nasopharyngeal epithelial cells, 17th International Symposium on EBV and associated diseases. 2016.

Tsao G.S.W., ZHANG J., Jia L.J., Tsang C.M., Lin W., Yip Y.L., Deng W., Lo K.W. and Lung M.L., The role of EBV infection in aerobic glycolysis in nasopharyngeal carcinoma., AACR Annual Meeting 2017.

Wang N., Wang X., TAN H.Y., LI S., Tsang C.M., Tsao G.S.W. and Feng Y., Berberine Suppresses Cyclin D1 Expression through Proteasomal Degradation in Human Hepatoma Cells, International Journal of Molecular Sciences. 2016, 17: 1899.

ZHANG J., Jia L.J., Lin W., Yip Y.L., LAU V.M.-.Y., Zhu D., Tsang C.M., Zhou Y.L., Deng W., Lung H.L., Lung M.L., Cheung A. and Tsao G.S.W., Epstein-Barr Virus Encoded Latent Membrane Protein-1 Induces Glucose Transporter-1 Transcription is Dependent on the mTORC1 Mediated NF-κB Pathway Activation, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

ZHANG J., Jia L.J., Lin W., Yip Y.L., Lo K.W., LAU V.M.-.Y., Zhu D., Tsang C.M., Zhou Y., Deng W., Lung H.L., Lung M.L., Cheung L.M. and Tsao G.S.W., Epstein-barr Virus-encoded Latent Membrane Protein 1 Upregulates Glucose Transporter 1 Transcription Via The Mtorc1/nf-κb Signaling Pathways, Journal of Virology. 2017, 91: e02168-16.

Researcher : Tsang KY

List of Research Outputs

CHU T.L., Tsang K.Y., Tsang S.W., Zhou Z. and Cheah K.S.E., MMP14 Regulates Lineage Progression of Hypertrophic Chondrocytes, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

CHU T.L., Tsang K.Y., Zhou Z. and Cheah K.S.E., MMP14 and Regulation of the Hypertrophic Chondrocyte to Osteoblast Lineage, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

SO K.H., Kudelko M.A., Tan Z., Wang C., Chan W.C.W., Tsang K.Y., Cheah K.S.E. and Chan D., FGF21 Up-Regulates Glycolytic Proteins for Hypertrophic Chondrocyte Survival under ER Stress, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Tsang K.Y., Li X.Y., Wu M.H., Jin G., Chan D., Zhang M.Q. and Cheah K.S.E., Single cell transcriptomes reveal a mesenchymal state during chondrocyte to osteoblast transition., Keystone Symposium Single Cell Omics, May 26-30, 2017, Stockholm. 2017.

Researcher : Tsang SL

List of Research Outputs

Cheng M.H., Tam C.N., Choy K.W., Tsang W.H., Tsang S.L., Pang C.P., Song Y. and Sham M.H., A γA-Crystallin Mouse Mutant Secc with Small Eye, Cataract and Closed Eyelid, PLOS ONE. 2016, 11: e0160691.

LIU Y., Wang B., Wong Y.M.E., Tsang S.L., HO C.C., Hui C.C. and Sham M.H., The roles of Irx3 and Irx5 in inner ear neurosensory patterning, 18th International Congress of Developmental Biology. 2017.

LIU Y., Wang B., Wong Y.M.E., Tsang S.L., HO C.C., Hui C.C. and Sham M.H., The roles of Irx3 and Irx5 in inner ear neurosensory patterning, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : Tsao GSW

Project Title:	The role of TGF-beta in EBV infection and pathogenesis of nasopharyngeal carcinoma
Investigator(s):	Tsao GSW, Lan HY
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	01/2009

Project Title:	Systematic Development of Molecular Targets for Nasopharyngeal Carcinoma
Investigator(s):	Tsao GSW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	01/2014

Project Title:	Dynamics of EBV episome maintenance in infected nasopharyngeal epithelial cells
Investigator(s):	Tsao GSW, Chen H, Deng W
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014

Project Title:	Regulation of invadopodia formation by the EBV-encoded LMP1 in nasopharyngeal epithelial cells
Investigator(s):	Tsao GSW
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	Delineating the signal pathways of LMP1 in the activation of mTOR signaling in nasopharyngeal carcinoma cells
Investigator(s):	Tsao GSW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2015
Completion Date:	04/2017

Project Title:	Establishment of a shared live cell imaging platform for super-resolution microscopy
Investigator(s):	Tsao GSW, Bruzzone R, Chang RCC, Cheung MCH, Ching YP, Huen MSY, Jin D, Yang D, Yu C, Yuen KWY
Department:	Anatomy
Source(s) of Funding:	Collaborative Research Fund (CRF) - Major Equipment Project
Start Date:	06/2015

Project Title:	Advanced Imaging - From System Biology to Single Cell & Single Molecule Analysis
Investigator(s):	Tsao GSW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Croucher Summer Courses
Start Date:	07/2015

Project Title:	Biomimetic 3D Microsystem to Study Tumour Survival and Drug Responses
Investigator(s):	Tsao GSW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2016

Project Title:	Immortalization of nasopharyngeal epithelial cells by the EBV-encoded LMP1
Investigator(s):	Tsao GSW
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2016

Project Title:	American Association for Cancer Research Annual Conference 2017; The role of EBV infection in aerobic glycolysis in nasopharyngeal carcinoma
Investigator(s):	Tsao GSW
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2017
Completion Date:	04/2017

Project Title:	High speed and high-sensitivity fluorescent live cell imaging system
Investigator(s):	Tsao GSW, Yu C
Department:	Anatomy
Source(s) of Funding:	Small Equipment Grant
Start Date:	06/2017

Project Title:	Preclinical evaluation of therapeutic use of a selective cdk4/6 inhibitor (PD-0332991) in nasopharyngeal carcinoma (NPC).
Investigator(s):	Tsao GSW, Lui WYV, Lee WMA
Department:	Anatomy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2017

Project Title:	Regulation and pathogenic role of latent infection of Epstein-Barr virus in nasopharyngeal carcinoma
Investigator(s):	Tsao GSW, Chen H, Jin D, Kok KH
Department:	School of Biomedical Sciences
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2017

List of Research Outputs

CAHK W., LUNG R.W., TONG J.H., CHAN S.Y., LUN S.W., Tsao G.S.W., LO K. and TO K., Down-regulation of long non-coding RNA MEG3 in nasopharyngeal carcinoma, Molecular Carcinogenesis. 2016.

CAO F., Tsao G.S.W. and Yu C., Regulation of Integrin beta3 Endocytosis at the Podosome, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

CHAN M.H.M., Lau K.L.K., Lin W., Tsao G.S.W. and Tsang C.M., The interaction of berberine with chemodrugs on Epstein-Barr virus (EBV)-associated nasopharyngeal carcinoma, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Chan J.F.W., Yip C.Y., Tsang O.L., Tee K.M., Cai J., Chik K.K.H., Zhu Z., Chan C.S., CHOI K.Y., Sridhar S., Zhang J., Lu G., Chiu K., Lo A.C.Y., Tsao G.S.W., Kok K.H., Jin D., Chan K.H. and Yuen K.Y., Differential cell line susceptibility to the emerging Zika virus: implications for disease pathogenesis, non-vector-borne human transmission and animal reservoirs, Emerging Microbes & Infections. 2016, 5: e93.

FUNG S.W., Cheung P.F.Y., Yip C.W., NG W.C., Cheung T.T., CHONG C.C.N., Tsao G.S.W. and CHEUNG S.T., Expression of ATP-binding cassette transporter ABCF1 in fetal liver and liver cancer associated with cancer stem cell markers and chemo-resistance, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Fang X., Jeong J.H., Long X., Park S.J., Wang D., Shuai M., Wei R., Li C., Li S., Zhang S., Duran M.B., Lo K.W., Tsao G.S.W., Glaser R., Luo Z., Feng X., Tian Y. and Luo J.L., IKKα-mediated biogenesis of miR-196a through interaction with Drosha regulates the sensitivity of cancer cells to radiotherapy, Cell Death and Differentiation. 2016, 23: 1471-1482.

Fung T.M., Ng K.Y., Tong M., CHEN J., Chai S., Chan K.T., Law S.Y.K., Lee N.P.Y., Choi M.Y., Li B., Cheung A., Tsao G.S.W., Qin Y.R., Guan X., Chan K.W. and Ma S.K.Y., Neuropilin-2 promotes tumourigenicity and metastasis in oesophageal squamous cell carcinoma through ERK-MAPK-ETV4-MMP-E-cadherin deregulation, Journal of Pathology. 2016, 239(3): 309-319.

Jia L.J., Tsang C.M., Yip Y.L., ZHANG J., Deng W. and Tsao G.S.W., Establishment and characterization of immortalized nasopharyngeal epithelial cells with stable infection of Epstein-Barr virus, 4th International Anatomical Sciences & Cell Biology Conference. 2016.

Jia L.J., Tsang C.M., Yip Y.L., Law W.T., ZHANG J., Deng W. and Tsao G.S.W., Establishment and characterization of immortalized nasopharyngeal epithelial cells with stable infection of Epstein-Barr virus, AMPK 2016: New Mechanism and Physiology. 2016.

Jia L.J., ZHANG J., Yip Y.L., Lin W., Jin D., Tsang C.M. and Tsao G.S.W., Hypoxia induces lytic reactivation of Epstein-Barr virus in stable M81-infected nasopharyngeal epithelial cells, Keystone Symposia Conference on Tumor Metabolism: Mechanisms and Targets. 2017.

Lee H.M., Lo K.W., Wei W., Tsao G.S.W., Chung G.T.Y., Ibrahim M.H., Dawson C.W., Murray P.G., Paterson I.C. and Yap L.F., Oncogenic S1P signalling in EBV-associated nasopharyngeal carcinoma activates AKT and promotes cell migration through S1P receptor 3, The Journal of Pathology. 2017, 242(1): 62-72.

Li B., XU W., Lam A.K.Y., Wang Y.A.N.G., Hu H.-.F., Guan X., Qin Y.R., Saremi N., Tsao G.S.W., He Q.-.Y. and Cheung A., Significance of PI3K/AKT signaling pathway in metastasis of esophageal squamous cell carcinoma and its potential as a target for anti-metastasis therapy, Oncotarget. 2017, 8: 38755-38766.

Li Y.Y., Chung G.T., Lui W.Y.V., To K.F., Ma B.B., Chow C., Woo J.K., Yip K.Y., Seo J., Hui E.P., Mak M.K., Rusan M., Chau N.G., Or Y.Y., Law M.H., Law P.P., Liu Z.W., NGAN H.L., Hau P.M., Verhoeft K.R., Poon P.H., Yoo S.K., Shin J.Y., Lee S.D., Lun S.W., Jia L.J., Chan A.W., Chan J.Y., Lai P.B., Fung C.Y., Hung S.T., Wang L., Chang A.M., Chiosea S.I., Hedberg M.L., Tsao G.S.W., van Hasselt A.C., Chan A.T., Grandis J.R., Nature Communications P.S. and Lo K.W., Exome and genome sequencing of nasopharynx cancer identifies NF-κB pathway activating mutations, Nature Communications. 2017.

NGAN H.L., Tsao G.S.W. and Lui W.Y.V., MAPK Pathway Mutations in Head and Neck Squamous Cell Carcinoma (HNSCC), 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

Sharmila V., Tsao G.S.W., Tsang C.M., Dawson C., Paterson I.C. and Yap L.F., The Role of Transforming Growth Factor-β Signalling in Persistent EBV Infection of Nasopharyngeal Epithelial Cells, 4th International Anatomical Sciences & Cell Biology Conference. 2016.

TANG W.C., Tsang C.M., Jones G.E. and Tsao G.S.W., Formation of invadopodia in LMP1-expressing nasopharyngeal epithelial cells, 17th International Symposium on EBV and associated diseases. 2016.

Tsang C.M., TANG W.C., Jones G.E. and Tsao G.S.W., The roles of tumor-associated macrophages in potentiating the invasiveness of EBV-infected nasopharyngeal epithelial cells, 17th International Symposium on EBV and associated diseases. 2016.

Tsao G.S.W., Establishment and characterization of new NPC xenografts and cell lines for EBV studies, 17th International Association for Research on EBV and associated diseases. 2016.

Tsao G.S.W., Establishment of NPC cell line & EBV infection of nasopharyngeal epithelial cells, 31st Japanese Herpes Viruses meeting. 2017.

Tsao G.S.W., Recent advances in nasopharyngeal carcinoma (NPC) and EBV infection, The 6th NPC Research Day. 2017.

Tsao G.S.W., ZHANG J., Jia L.J., Tsang C.M., Lin W., Yip Y.L., Deng W., Lo K.W. and Lung M.L., The role of EBV infection in aerobic glycolysis in nasopharyngeal carcinoma., AACR Annual Meeting 2017.

Tsao G.S.W., The role of EBV infection in the pathogenesis of nasopharyngeal carcinoma, ICGEB Workshop on human papilloma. 2016.

Wang N., Wang X., TAN H.Y., LI S., Tsang C.M., Tsao G.S.W. and Feng Y., Berberine Suppresses Cyclin D1 Expression through Proteasomal Degradation in Human Hepatoma Cells, International Journal of Molecular Sciences. 2016, 17: 1899.

XU W., Li B., Guan X., Chung S.K., Yang W., Yip Y.L., Law S.Y.K., Chan K.T., Lee N.P.Y., Chan K.W., Xu L.Y., Li E.M., Tsao G.S.W., He Q.Y. and Cheung A., Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression, Nature Communications. 2017, 8: 14399.

Xia W., Lo C.M., Poon R.Y.C., Cheung T.T., Chan A.C.Y., Chen L., YANG S., Tsao G.S.W. and Wang X., Smad inhibitor induces CSC differentiation for effective chemosensitization in cyclin D1- and TGF-β/Smad-regulated liver cancer stem cell-like cells, Oncotarget. 2017, 8(24): 38811-38824.

Yip C.W., Lam C.Y., Poon T.C.W., Cheung T.T., Cheung P.F.Y., Fung S.W., Wang X., LEUNG C.Y.I., Ng L.W.C., Lo C.M., Tsao G.S.W. and Cheung S.T., Granulin-epithelin precursor interacts with 78-kDa glucose-regulated protein in hepatocellular carcinoma, BMC Cancer. 2017, 17(1): 409.

ZHANG J., Jia L.J., Lin W., Yip Y.L., LAU V.M.-.Y., Zhu D., Tsang C.M., Zhou Y.L., Deng W., Lung H.L., Lung M.L., Cheung A. and Tsao G.S.W., Epstein-Barr Virus Encoded Latent Membrane Protein-1 Induces Glucose Transporter-1 Transcription is Dependent on the mTORC1 Mediated NF-κB Pathway Activation, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

ZHANG J., Jia L.J., Lin W., Yip Y.L., Lo K.W., LAU V.M.-.Y., Zhu D., Tsang C.M., Zhou Y., Deng W., Lung H.L., Lung M.L., Cheung L.M. and Tsao G.S.W., Epstein-barr Virus-encoded Latent Membrane Protein 1 Upregulates Glucose Transporter 1 Transcription Via The Mtorc1/nf-κb Signaling Pathways, Journal of Virology. 2017, 91: e02168-16.

ZHOU Y., Zhang Y.G., CAO F., SIT H.M., Tsao G.S.W. and Yu C., Define the Functional Role of Myosin-1e at the Macrophage Podosome, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

Researcher : Tse G

List of Research Outputs

Choy L., Yeo J.M., Tse V., Chan S.P. and Tse G., Cardiac disease and arrhythmogenesis: Mechanistic insights from mouse models, IJC Heart & Vasculature. 2016, 12: 1-10.

Researcher : Tsui YP

Project Title:	Axonal regulation of peripheral nervous system glia identity
Investigator(s):	Tsui YP, Chan YS
Department:	Physiology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2015
Completion Date:	08/2016

List of Research Outputs

Chan Y.S., Tsui Y.P. and Shum D.K.Y., Preservation of Schwann cell identity in vitro through bone morphogenetic protein signaling, Soc. Neuroscience Abstract (USA), 390.05 [San Diego. Nov. 12-16, 2016]. 2016.

Shum D.K.Y., Tsui Y.P., Cai S. and Chan Y.S., iPSC-derived sensory neurons for fate commitment of bone marrow-derived Schwann cells: Implication for re-myelination therapy, Frontiers in Cellular Neuroscience [14^th Meeting of Asian Pacific Society for Neurochemistry. Kuala Lumpur. August 27-30, 2016]. 2016.

Tsui Y.P., Wu L.K., Shum D.K.Y. and Chan Y.S., Cell therapy for CNS myelin disorders: Derivation of myelin-forming oligodendrocyte precursors from neural progenitors harbored by adult bone marrow stromal cells, Abstracts of 12^th Int’l Symp. on Healthy Aging: Science and Aging – Wellness and Longevity: From Science to Service: 81. [HK. March 11-12, 2017]. 2017.

Tsui Y.P., Mun K.L., Chan Y.S., Shum D.K.Y. and Shea G.K.H., Hypoxic preconditioning of marrow-derived progenitor cells as a source for the generation of mature Schwann cells, J. Visualized Experiments. 2017, 124.

Tsui Y.P., Tam K.W., Shum D.K.Y. and Chan Y.S., Schwann cells demonstrated lineage plasticity in culture and acquired oligodendrocyte phenotypes, International Society for Stem Cell Research Annual Meeting 2016.

Researcher : WANG L

List of Research Outputs

WANG L., ZHANG H., Wong Y.M.E. and Sham M.H., The role of Notch signalling during mouse craniofacial development, 18th International Congress of Developmental Biology. 2017.

WANG L., Zhang H. and Sham M.H., The role of Notch signalling during mouse pharyngeal arch development, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : WANG P

List of Research Outputs

GAO W., Tang H.M.V., CHENG Y., WANG P. and Jin D., Regulation of ubiquitination and degradation of CRTC1 transcriptional coactivator by salt-inducible kinase SIK1., 16th International Union of Biochemistry and Molecular Biology (IUBMB) Conference: Signaling Pathways in Development, Diseases and Aging.. Vancouver, Canada, 2016.

Researcher : WANG Y

List of Research Outputs

Tong Z., Wang M., Wang Y., Kim D.D., Grenier J.K., Cao J., Sadhukhan S., Hao Q. and Lin H.N., SIRT7 Is an RNA-Activated Protein Lysine Deacylase, ACS Chemical Biology. 2016.

WU T.H.E., LU L., WANG Y. and Ballard H.J., Connexin 43, Pannexin 1 and Cystic Fibrosis Transmembrane Conductance Regulator in the Regulation of ATP Release From Muscle, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

Wang Y., Fung E.Y.M., ZHANG W., He B., CHUNG W.H., Jin J., Hu J., Lin H.N. and Hao Q., Deacylation Mechanism by SIRT2 Revealed in the 1′-SH-2′-O-Myristoyl Intermediate Structure, Cell Chemical Biology. 2017, 24: 339-345.

Wang Y., Wu M.H., Cheung M.P.L., Sham M.H., Haruhiko A., Chan D., Cheah K.S.E. and Cheung M.C.H., Reprogramming of Dermal Fibroblasts into Osteo-Chondrogenic Cells with Elevated Osteogenic Potency by Defined Transcription Factors, Stem Cell Reports. 2017, 8: 1587-1599.

Xie Y., Ge J., Lei H., Peng B., Zhang H., Wang D., Pan S., Chen G., CHEN L., Wang Y., Hao Q., Yao S.Q. and Sun H.Y., Fluorescent Probes for Single-Step Detection and Proteomic Profiling of Histone Deacetylases, Journal of the American Chemical Society. 2016, 138: 15596-15604.

Researcher : WONG MY

List of Research Outputs

SHAH A.N., Hung H.L.C., Cheng S.Y., WONG M.Y., Legido-Quigley C. and Chang R.C.C., Oxyresveratrol mitigates cellular toxicity in and in-vitro and in-vivo model of Parkinson’s disease, The 13th International Conference on Alzheimer’s & Parkinson’s Diseases 2017, Section C02.g Therapeutic targets, mechanisms for treatment: anti- inflammatory, anti-oxidant.. 2017, 146.

WONG M.Y., SHAH A.N., CHENG S.Y. and Chang R.C.C., Effects on Oxyresveratrol on Motor and Cognitive Functions in 6-OHDA-Induced Parkinson’s Disease, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

WONG M.Y., SHAH A.N. and Chang R.C.C., Protective effects of oxyresveratrol on motor functions in 6-OHDA-Induced neurodegeneration, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

WONG M.Y., SHAH A.N. and Chang R.C.C., Protective effects of oxyresveratrol on motor functions in 6-OHDA-induced neurodegeneration. , The 12th International Symposium on Healthy Aging. 2017, 79.

Researcher : WONG NCS

List of Research Outputs

WONG N.C.S., Maturation of Human Pluripotent Stem Cell-Derived Cardiomyocyres in Three Dimensional Tissue Constructs (MPhil Thesis), The University of Hong Kong. 2017.

Researcher : WONG NHM

List of Research Outputs

. S., Yuen K.S., WONG N.H.M., CHENG T.F., Botelho M.G. and Jin D., CRISPR/Cas9 targeting of viral essential genes suppresses Epstein- Barr virus DNA load in nasopharyngeal carcinoma cells of latency II., The American Society for Virology 36th Annual Meeting, University of Wisconsin-Madison, Madison, Wisconsin, USA, June 23-28, 2017.. 2017.

WONG N.H.M., Yuen K.S., Chan C.P. and Jin D., Suppression of IFN-β production by Epstein-Barr virus lytic transactivator Zta., Immunology 2017 – The American Association of Immunologists Meeting, Walter E. Washington Convention Center, Washington, D.C., USA, May 12-16, 2017.. 2017.

Yuen K.S., WONG N.H.M. and Jin D., CRISPR/Cas9-facilitated construction of a bacterial artificial chromosome clone of Epstein-Barr virus from C666-1 nasopharyngeal carcinoma cells., 17th International Symposium on Epstein Barr Virus and Associated Diseases (EBV2016). Zurich, Switzerland, 2016.

Yuen K.S., Wang Z.M., WONG N.H.M., Zhang Z.Q., CHENG T.F., LUI W.Y., Chan C.P. and Jin D., Suppression of Epstein-Barr virus DNA load in latently infected nasopharyngeal carcinoma cells by CRISPR/Cas9, Virus Res.. 2017.

Yuen K.S., WONG N.H.M. and Jin D., Suppression of Epstein-Barr virus infection in nasopharyngeal carcinoma cells through CRISPR/Cas9 targeting of EBNA1, OriP and W repeats, In: Christian Münz, 17th International Symposium on EBV and associated diseases. 2016.

Researcher : WU THE

List of Research Outputs

WU T.H.E. and Ballard H.J., CFTR-associated ATP Release in Neonatal And Adult Skeletal Myoblasts, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

WU T.H.E., LU L., WANG Y. and Ballard H.J., Connexin 43, Pannexin 1 and Cystic Fibrosis Transmembrane Conductance Regulator in the Regulation of ATP Release From Muscle, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

Researcher : Wang B

List of Research Outputs

HO C.C., QIN T., Wang B., Wong Y.M.E., LIU Y., Hui C.C. and Sham M.H., Sufu controls the proliferation and differentiation of cochlear prosensory progenitors, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

HO C.C., QIN T., Wang B., Wong Y.M.E., LIU Y., Hui C.C. and Sham M.H., Sufu regulates the proliferation and differentiation of hair cell progenitors in mammalian cochlea, 18th International Congress of Developmental Biology. 2017.

LIU Y., Wang B., Wong Y.M.E., Tsang S.L., HO C.C., Hui C.C. and Sham M.H., The roles of Irx3 and Irx5 in inner ear neurosensory patterning, 18th International Congress of Developmental Biology. 2017.

LIU Y., Wang B., Wong Y.M.E., Tsang S.L., HO C.C., Hui C.C. and Sham M.H., The roles of Irx3 and Irx5 in inner ear neurosensory patterning, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : Wang C

List of Research Outputs

SO K.H., Kudelko M.A., Tan Z., Wang C., Chan W.C.W., Tsang K.Y., Cheah K.S.E. and Chan D., FGF21 Up-Regulates Glycolytic Proteins for Hypertrophic Chondrocyte Survival under ER Stress, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : Wang F

Project Title:	American Society for Virology - 2017 Annual Meeting; A Novel Transcript Isoform of IFI16 Attenuates Inflammasome Activation Mediated by the Cytoplasmic DNA Sensor AIM2
Investigator(s):	Wang F
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2017
Completion Date:	06/2017

List of Research Outputs

CHAUDHARY V., Yuen K.S., Chan J.F.W., Chan C.P., Wang F., Kok K.H., Chan C.P., Yuen K.Y. and Jin D., Zika virus NS5 protein differentially modulates type I and type II interferon signaling., Cross Street Immunology Conference, National Taiwan University, Taipei, March 18-19, 2017.. 2017.

Chaudhary V., Yuen K.S., Chan J.F.W., Chan C.P., Wang F., Cai J., Zhang S., Liang M., Kok K.H., Chan C.P., Yuen K.Y. and Jin D., Selective activation of type II interferon signaling by Zika virus NS5 protein, J Virol. 2017, 91(14): e00163-17.

Wang F. and Jin D., A Novel Transcript Isoform of IFI16 Attenuates Inflammasome Activation Mediated by the Cytoplasmic DNA Sensor AIM2, American Society for Virology 36th Annual Meeting . 2017.

Wang F. and Jin D., A Novel Transcript Isoform of IFI16 Attenuates Inflammasome Activation Mediated by the Cytosolic DNA Sensor AIM2, Annual Scientific Meeting of the Hong Kong Society for Immunology 2016.

Wang F. and Jin D., American Society for Virology Postdoc Travel Award 2017, American Society for Virology. 2017.

Wang F., FUNG S.Y., Chan C.P. and Jin D., Induction by HTLV-1 of a transcript isoform of STING that suppresses innate antiviral response., 18th International Conference on Human Retrovirology: HTLV-1 and Related Viruses, Tokyo, Japan, March 7-10, 2017.. 2017.

Wang F. and Jin D., Poster Presentation Award of Annual Scientific Meeting of the Hong Kong Society for Immunology 2016, the Hong Kong Society for Immunology. 2016.

Researcher : Wang JJ

Project Title:	Outstanding Young Researcher Award 2011-12
Investigator(s):	Wang JJ
Department:	Biochemistry
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	01/2013

Project Title:	Understanding the effects of DNA methylation on gene expression - a computational approach
Investigator(s):	Wang JJ, Wong MP, Chim JCS
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2015

List of Research Outputs

Chan D.W., Hui W.W., Wang J.J., Yung M.H., Hui M.N., Qin Y.I.M.I.N.G., LIANG R., Leung T.H.Y., Xu D., Chan K.K.L., Yao K.M., Tsang B.K. and Ngan H.Y.S., DLX1 acts as a crucial target of FOXM1 to promote ovarian cancer aggressiveness by enhancing TGF-b/SMAD4 signaling, In: Drs. Douglas Green and Justin Stebbing , Oncogene. UK, Macmillan Publishers Limited, 2016, 36: 1404-1416.

QIN Y., Ng R.K., Ng T.W., Tong K.K., Au Y.K., Niu B., Tan Z., Yip M.S., Wang J.J., Sham P.C. and Cheah K.S.E., Genome-wide identification of active enhancers in the developing mouse nucleus pulposus, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

YIP S.H., Wang P., KOCHER J.P., Sham P.C. and Wang J.J., Linnorm: Improved statistical analysis for single cell RNA-seq expression data, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : Wang Y

List of Research Outputs

Tong Z., Wang M., Wang Y., Kim D.D., Grenier J.K., Cao J., Sadhukhan S., Hao Q. and Lin H.N., SIRT7 Is an RNA-Activated Protein Lysine Deacylase, ACS Chemical Biology. 2016.

Researcher : Wang Y

Project Title:	Structural basis of sirt6 catalytic mechanism investigation and the inhibitors design
Investigator(s):	Wang Y, Hao Q
Department:	Physiology
Source(s) of Funding:	Small Project Funding
Start Date:	03/2015
Completion Date:	08/2016

List of Research Outputs

Tong Z., Wang M., Wang Y., Kim D.D., Grenier J.K., Cao J., Sadhukhan S., Hao Q. and Lin H.N., SIRT7 Is an RNA-Activated Protein Lysine Deacylase, ACS Chemical Biology. 2016.

Researcher : Wong NS

Project Title:	Kappa-opioid receptor mediated cellular stress response: the role of Inositol 1,4,5-trisphosphate and diacylglycerol
Investigator(s):	Wong NS, Yao KM
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2002

Project Title:	Cellular stress responses in cancer cells with impaired glycogen metabolism
Investigator(s):	Wong NS
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

List of Research Outputs

YE L., Wong N.S. and Ho J.W.Y., Design,Development and Evaluation of Biochemistry Virtual Laboratory for Blended Learning, GSTF Journal of Education. 2016, 3: 40-45.

Researcher : Wong SL

Project Title:	Deciphering combinational genetics
Investigator(s):	Wong SL
Department:	School of Biomedical Sciences
Source(s) of Funding:	Start-up Allowance for Returning Croucher Award Recipients
Start Date:	05/2016

Project Title:	High-throughput discovery of combination therapies by CombiGEM-CRISPR
Investigator(s):	Wong SL
Department:	School of Biomedical Sciences
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	01/2017

Project Title:	Advancing the development of combinatorial genetics platforms
Investigator(s):	Wong SL
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2017

List of Research Outputs

Wong S.L., Combinatorial Genetics Platforms for Tackling Complex Diseases, Department of Pathology. 2016.

Wong S.L., Deciphering Complex Genetics for Biomedical Applications, 12th International Symposium on Healthy Aging “Wellness and Longevity: From Science to Service". 2017.

Wong S.L., Choi C.G. and Lu T.K., Deciphering combinatorial genetics, Annual Reviews of Genetics . 2016, 50: 515-538.

Wong S.L., Early Career Award, Research Grant Council, Hong Kong . 2016.

Researcher : Wong SM

List of Research Outputs

YU Z., TANG L.F., WANG J., Bao S., SHIEH J.T., LEUNG A.W.L., Gao F., ZHANG Z., WONG S.Y.Y., HUI A.L.C., Dung W.F., ZHANG Z., Fan Y., Wong S.M., Sham P.C., AZHAR A., KWOK P.Y., TAM P.P.L., Lian Q. and Cheah K.S.E., Hnrnpa1 Mutations Cause Congenital Heart Defects, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : Wong TL

Project Title:	American Association for Cancer Research Annual Meeting 2017; Downregulation of PRMT6 promotes the Warburg effect in hepatocellular carcinoma via PKM2
Investigator(s):	Wong TL
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2017
Completion Date:	04/2017

Project Title:	Role of ASNS in the development of HCC via modulating cancer stemness properties
Investigator(s):	Wong TL, Ma SKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Mini Grant
Start Date:	04/2017

List of Research Outputs

Wong T.L., CHE N. and Ma S.K.Y., Reprogramming of Central Carbon Metabolism in Cancer Stem Cells, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2017, 1863: 1728-1738.

Researcher : Wong WM

List of Research Outputs

Wang Q., Guo W., Hao B., Shi X., Lu Y., Wong W.M., Ma V.W., Yip T.T., Au S.K., Hao Q., Cheung K.H., Wu W., Li G.R. and Yue J., Mechanistic study of TRPM2-Ca 2+ -CAMK2-BECN1 signaling in oxidative stress-induced autophagy inhibition , Autophagy. 2016, 12: 1340-1354.

Researcher : Wong YME

Project Title:	Genetic analyses of Cdo and Boc function in inner ear development
Investigator(s):	Wong YME, Sham MH
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	Functional characterization of Six1 on inner ear hair cell ciliary bundle formation
Investigator(s):	Wong YME, Sham MH
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research for Resubmission of GRF/ECS Proposals
Start Date:	07/2016
Completion Date:	11/2016

List of Research Outputs

HO C.C., QIN T., Wang B., Wong Y.M.E., LIU Y., Hui C.C. and Sham M.H., Sufu controls the proliferation and differentiation of cochlear prosensory progenitors, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

HO C.C., QIN T., Wang B., Wong Y.M.E., LIU Y., Hui C.C. and Sham M.H., Sufu regulates the proliferation and differentiation of hair cell progenitors in mammalian cochlea, 18th International Congress of Developmental Biology. 2017.

LIU Y., Wang B., Wong Y.M.E., Tsang S.L., HO C.C., Hui C.C. and Sham M.H., The roles of Irx3 and Irx5 in inner ear neurosensory patterning, 18th International Congress of Developmental Biology. 2017.

LIU Y., Wang B., Wong Y.M.E., Tsang S.L., HO C.C., Hui C.C. and Sham M.H., The roles of Irx3 and Irx5 in inner ear neurosensory patterning, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Li J., Rodriguez Y., Cheng C., Zeng L., Wong Y.M.E., Xu C.Y., Zhou M.M. and Xu P.X., EYA1's conformation-specificity in dephosphorylating phosphothreonine in Myc and its activity on Myc stabilization in breast cancer, Molecular and Cellular Biology. 2016.

WANG L., ZHANG H., Wong Y.M.E. and Sham M.H., The role of Notch signalling during mouse craniofacial development, 18th International Congress of Developmental Biology. 2017.

Wong Y.M.E. and Sham M.H., The roles of Hedgehog receptors Cdo and Boc in controlling cochlear hair cell formation, Gordon Research Conference Auditory System 2016 in Bates College, Maine, USA, 10- 15 July 2016. 2016.

Wong Y.M.E., LIANG Y., LIU Y. and Sham M.H., The roles of Hedgehog receptors Cdo and Boc in controlling cochlear hair cell formation, Gordon Research Conference: Auditory System 2016.

Researcher : Wu LK

Project Title:	FENS Forum of Neuroscience 2016; Neuron-astrocyte signaling in perineuronal net formation
Investigator(s):	Wu LK
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2016
Completion Date:	07/2016

List of Research Outputs

Li Y.H., Han L., Wu L.K. and Chan Y.S., Activation of 5-HT₇ receptors reverses NMDA receptor-dependent LTD by activating PKA at medial vestibular neurons, Neuropharmacology. 2017, 123: 242-248.

Tsui Y.P., Wu L.K., Shum D.K.Y. and Chan Y.S., Cell therapy for CNS myelin disorders: Derivation of myelin-forming oligodendrocyte precursors from neural progenitors harbored by adult bone marrow stromal cells, Abstracts of 12^th Int’l Symp. on Healthy Aging: Science and Aging – Wellness and Longevity: From Science to Service: 81. [HK. March 11-12, 2017]. 2017.

Wu L.K., Shum D.K.Y. and Chan Y.S., Neuron-astrocyte signaling In perineuronal net formation, 10^th FENS Forum of Neuroscience (FENS 2016). 2016.

Researcher : Wu MH

List of Research Outputs

Tsang K.Y., Li X.Y., Wu M.H., Jin G., Chan D., Zhang M.Q. and Cheah K.S.E., Single cell transcriptomes reveal a mesenchymal state during chondrocyte to osteoblast transition., Keystone Symposium Single Cell Omics, May 26-30, 2017, Stockholm. 2017.

Wang Y., Wu M.H., Cheung M.P.L., Sham M.H., Haruhiko A., Chan D., Cheah K.S.E. and Cheung M.C.H., Reprogramming of Dermal Fibroblasts into Osteo-Chondrogenic Cells with Elevated Osteogenic Potency by Defined Transcription Factors, Stem Cell Reports. 2017, 8: 1587-1599.

Researcher : Wu W

Project Title:	Effects of chondroitinase ABC and lithium chloride on neuronal survival and regeneration after spinal cord injury
Investigator(s):	Wu W, Yick LW, So KF
Department:	Anatomy
Source(s) of Funding:	Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:	11/2003

Project Title:	Research Output Prize
Investigator(s):	Wu W, Su H, Wong WM, So KF, Wu EX
Department:	Anatomy
Source(s) of Funding:	Research Output Prize (in Faculty)
Start Date:	10/2008

Project Title:	Spinal cord injury in developing and adult rats: different outcome and potential mechanisms.
Investigator(s):	Wu W
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2015
Completion Date:	02/2017

Project Title:	Repairing neural damage after spinal cord injury with self-assembling peptide nanofiber scaffold (SAPNS)
Investigator(s):	Wu W
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2015

Project Title:	Enhancing axonal regeneration of spinal motoneurons after root avulsion by manipulation of chondroitin sulfate proteoglycans (CSPGs)
Investigator(s):	Wu W, Huang J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2016

Project Title:	the 2016 Tissue Engineering and Regenerative Medicine International Society- Asia Pacific Meeting (TERMIS-AP 2016); Repairing damage in the nervous tissue with biomaterials and neural stem cells
Investigator(s):	Wu W
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2016
Completion Date:	09/2016

List of Research Outputs

CHAN K.C., ZHOU Y., LIU S.S., van der Merwe Y., FAN S., HUNG K., Chung S.K., Wu W., So K.F. and Wu E.X., Longitudinal Assessments of Normal and Perilesional Tissues in Focal Brain Ischemia and Partial Optic Nerve Injury with Manganese-enhanced MRI, Scientific Reports. 2017, 7: 43124.

Heng B.C.A., GONG T., Wang S., Lim L.W., Wu W. and Zhang C., Decellularized Matrix Derived from Neural Differentiation of Embryonic Stem Cells Enhances the Neurogenic Potential of Dental Follicle Stem Cells, Journal of Endodontics. 2017, 43(3): 409-416.

RUVEN C. and Wu W., Transplantation of embryonic spinal cord derived cells to prevent muscle atrophy after various peripheral nerve injuries, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Wang Q., Guo W., Hao B., Shi X., Lu Y., Wong W.M., Ma V.W., Yip T.T., Au S.K., Hao Q., Cheung K.H., Wu W., Li G.R. and Yue J., Mechanistic study of TRPM2-Ca 2+ -CAMK2-BECN1 signaling in oxidative stress-induced autophagy inhibition , Autophagy. 2016, 12: 1340-1354.

Researcher : XIONG C

List of Research Outputs

XIONG C., Genetic Contribution To Intervertebral Disc Maintenance In Mice (MPhil Thesis), The University of Hong Kong. 2016.

Researcher : XIONG G

List of Research Outputs

XIONG G., Chen S. and Lin B., Prolong the Survival of Photoreceptors by Modulating the Apoptosis Pathway in a Mouse Model of Retinitis Pigmentosa, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

Researcher : XU C

List of Research Outputs

XU C., LIN Q., DENG J., Yu B., ARYA S. and Huang J., Live attenuated Salmonella-based Vaccines delivering SaEsxA by Type III Secretion System Confer Protection against Staphylococcus aureus Infection, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : XU H

List of Research Outputs

GAO X., XU H., Ho J.C.M., Chan S.H., Sham P.C., Xiao Z., Lee V.H.F., WANG S., Yam J.W.P. and Wong M.P., Uncovering Resistant Genes in EGFR-mutated Lung Adenocarcinomas Prior to Targeted Therapy, Health Research Symposium 2017. Hong Kong, 2017.

Researcher : XU W

List of Research Outputs

Cheung A., Li B., Xu W., Liu J. and Chan K.W., miR-29c modulates chemoresistance in esophageal cancer cells by suppressing FBXO31, European Journal of Cancer (24th Biennial Congress of the European Association for Cancer Research). 2016, 61 Suppl 1: S64.

Li B., XU W., Lam A.K.Y., Wang Y.A.N.G., Hu H.-.F., Guan X., Qin Y.R., Saremi N., Tsao G.S.W., He Q.-.Y. and Cheung A., Significance of PI3K/AKT signaling pathway in metastasis of esophageal squamous cell carcinoma and its potential as a target for anti-metastasis therapy, Oncotarget. 2017, 8: 38755-38766.

XU W., Li B., Guan X., Chung S.K., Yang W., Yip Y.L., Law S.Y.K., Chan K.T., Lee N.P.Y., Chan K.W., Xu L.Y., Li E.M., Tsao G.S.W., He Q.Y. and Cheung A., Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression, Nature Communications. 2017, 8: 14399.

XU W., Li N.F. and Chen J., Effects of the Apical Krebs Solution on Ion Transport of Cultured Pig Tracheal Epithelia, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

XU W., Li N.F. and Chen J., Sodium in The Apical Solution Mediates Downregulation of Ion Transport in Cultured Pig Tracheal Epithelia, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : XU W

List of Research Outputs

Researcher : Xie S

List of Research Outputs

Xie S., Outstanding Research Output Award, LKS Faculty of Medicine, HKU. 2017.

YAN L., Xie S., DU Y. and Qian C., Structural Insights into BAF47 and BAF155 Complex Formation, Journal of Molecular Biology. 2017, 429: 1650-1660.

YAN L., Xie S., DU Y. and Qian C., Structural and Biochemical Study of Core Regulatory Machinery of BAF Chromatin Remodeling Complex, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

YAN L., Xie S., DU Y. and Qian C., Structural insights into BAF47 and BAF155 complex formation, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : Xu W

List of Research Outputs

Researcher : Xue W

List of Research Outputs

He S., Xue W., DUAN Z., Sun Q., Li X., Gan H., Huang J. and Qu J., Multimodal Nonlinear Optical Microscopy Reveals Critical Role of Kinesin-1 in Cartilage Development, Biomedical Optics Express. 2017, 8(3): 1771-1782.

Researcher : YAN L

List of Research Outputs

YAN L., Xie S., DU Y. and Qian C., Structural Insights into BAF47 and BAF155 Complex Formation, Journal of Molecular Biology. 2017, 429: 1650-1660.

YAN L., Xie S., DU Y. and Qian C., Structural and Biochemical Study of Core Regulatory Machinery of BAF Chromatin Remodeling Complex, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

YAN L., Xie S., DU Y. and Qian C., Structural insights into BAF47 and BAF155 complex formation, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : YANG X

List of Research Outputs

Ng R.K., YANG X. and Lam Y.M., Dysregulation of DNA methylation at gene regulatory regions in MLL-rearranged leukemia, Epigenomics of Common Diseases November 1-4, 2016, Cambridge, UK. 2016.

YANG X., Cheung M.P.L., Liang R. and Cheung M.C.H., Elucidating the role of DLC1 in Metastatic Melanoma, 4th International Anatomical Sciences & Cell Biology Conference. 2016.

YANG X., Lam Y.M., Lui W.C. and Ng R.K., Epigenetic dysregulation of transcriptional program in MLL-EEN leukemia, American Association for Cancer Research (AACR) Annual Meeting April 1-5,2017, Washington DC, USA. 2017.

Researcher : YANG X

List of Research Outputs

Ng R.K., YANG X. and Lam Y.M., Dysregulation of DNA methylation at gene regulatory regions in MLL-rearranged leukemia, Epigenomics of Common Diseases November 1-4, 2016, Cambridge, UK. 2016.

YANG X., Cheung M.P.L., Liang R. and Cheung M.C.H., Elucidating the role of DLC1 in Metastatic Melanoma, 4th International Anatomical Sciences & Cell Biology Conference. 2016.

Researcher : YE L

List of Research Outputs

YE L., Wong N.S. and Ho J.W.Y., Design,Development and Evaluation of Biochemistry Virtual Laboratory for Blended Learning, GSTF Journal of Education. 2016, 3: 40-45.

YE L., Chan L.K., Bridges S.M. and Ganotice F.J.A., Technology Enhanced Interprofessional Education in Health Sciences Education: A Systematical Review, Frontiers in Medical and Health Sciences Education. 2016.

Researcher : YIP KHR

List of Research Outputs

YIP K.H.R., SOX9 mutations and molecular pathogenesis of Campomelic Dysplasia (PhD Thesis), The University of Hong Kong. 2016.

Researcher : YIP SH

List of Research Outputs

YIP S.H., Wang P., KOCHER J.P., Sham P.C. and Wang J.J., Linnorm: Improved statistical analysis for single cell RNA-seq expression data, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : YOU R

List of Research Outputs

Chang R.C.C., YOU R., Hung H.L.C. and Ho Y.S., Environmental pollutants as risk factos for developing cognitive dysfunctions and Alzheimer’s disease. , The 10th Annual Scientific Meeting of Hong Kong Society of Biological Psychiatry: Brain and the Environment II. . 2017, 13.

YOU R., Ho Y.S., Hung H.L.C. and Chang R.C.C., Evaluating the implication of silica nanoparticles in neurodegeneration, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

YOU R., Hung H.L.C., Ho Y.S. and Chang R.C.C., Investigating the effects of silica nanoparticles on neurodegeneratioive-like changes in behaviors and neuropathology. , International Alzheimer’s Disease Conference 2017. 40.

YOU R., Ho Y.S., Hung H.L.C., Lai S.W.C. and Chang R.C.C., Investigating the effects of slicia nanoparticles as affective and cognitive behaviors. , The 12th International Symposium on Healthy Aging. 2017, 50.

Researcher : YU Z

List of Research Outputs

YU Z., TANG L.F., WANG J., Bao S., SHIEH J.T., LEUNG A.W.L., Gao F., ZHANG Z., WONG S.Y.Y., HUI A.L.C., Dung W.F., ZHANG Z., Fan Y., Wong S.M., Sham P.C., AZHAR A., KWOK P.Y., TAM P.P.L., Lian Q. and Cheah K.S.E., Hnrnpa1 Mutations Cause Congenital Heart Defects, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : Yan B

Project Title:	Uncovering combinatorial regulation of transcription factors and microRNAs on cardiomyocyte differentiation from pluripotent stem cells
Investigator(s):	Yan B, Boheler KR
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

Project Title:	Integrative identification of IRX4 regulatory function in ventricular cardiomyocyte differentiation from human pluripotent stem cells
Investigator(s):	Yan B, Boheler KR
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2017

List of Research Outputs

Guan D., Yan B., Thieme C., Hua J., Zhu H., Boheler K.R., Zhao Z., Kragler F., Xia Y. and Zhang S., PlaMoM: a comprehensive database compiles plant mobile macromolecules, Nucleic Acids Res. 2017, 45(D1): D1021-D1028.

Li J., Li J., Liu Z., Yan B., Pan Z., Huang D., Liang Q., Ying D., Xu F., Yao H., Wang P., Kocher J.A., Xia Z., Sham P.C., Liu J.S. and Wang J.J., cepip: context-dependent epigenomic weighting for prioritization of regulatory variants and disease-associated genes, Genome Biol. 2017, 18(1): 52.

Li J., Yao H., Huang D., Liu H., Liu Z., Xu H., Qin Y., Prinz J., Xia W., Wang P., Yan B., Tran N.L., Kocher J.P., Sham P.C. and Wang J.J., mTCTScan: a comprehensive platform for annotation and prioritization of mutations affecting drug sensitivity in cancers, Nucleic Acids Res. 2017.

Researcher : Yao KM

Project Title:	Regulation of Bmi-1 expression by the Forkhead box transcription factor FoxM1
Investigator(s):	Yao KM
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2007

Project Title:	Investigating the role of FOXM1 in the maintenance of human embryonic stem cell pluripotency and genome stability
Investigator(s):	Yao KM, Cheung MCH
Department:	Biochemistry
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2012

Project Title:	Elucidating the nuclear function of EPS8/EPS8L2: Crosstalk with FOXM1 and regulation of cancer cell proliferation and migration/invasion
Investigator(s):	Yao KM, Chan DW
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2014

Project Title:	Identifying the cognate receptor of secreted PDZD2
Investigator(s):	Yao KM
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2015
Completion Date:	12/2016

Project Title:	Study of Zinc Finger And BTB Domain Containing 33 (ZBTB33) as putative FOXM1-interacting protein in the regulation of cancer cell proliferation
Investigator(s):	Yao KM, Lee CYL
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2017

List of Research Outputs

Chan D.W., Hui W.W., Wang J.J., Yung M.H., Hui M.N., Qin Y.I.M.I.N.G., LIANG R., Leung T.H.Y., Xu D., Chan K.K.L., Yao K.M., Tsang B.K. and Ngan H.Y.S., DLX1 acts as a crucial target of FOXM1 to promote ovarian cancer aggressiveness by enhancing TGF-b/SMAD4 signaling, In: Drs. Douglas Green and Justin Stebbing , Oncogene. UK, Macmillan Publishers Limited, 2016, 36: 1404-1416.

FUNG C.W., Chan W. and Yao K.M., Partnering role of FOXM1 and EPS8 in maintaining chemoresistance in human ovarian cancer, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Liu V.W.S., Yao W.L., Tam C.W., Yao K.M. and Shiu S.Y.W., Melatonin Inhibits Androgen Receptor Splice Variant-7 (AR-V7)-Induced Nuclear Factor-Kappa B (NF-κB) Activation and NF-κB Activator-Induced AR-V7 Expression in Prostate Cancer Cells: Potential Implications for the Use of Melatonin in Castration-Resistant Prostate Cancer (CRPC) Therapy., Int. J. Mol. Sci.. 2017, 18(6): pii: E1130.

Tsang K., Wong S.Y., Yao K.M., Chan B.P. and Lo A.C.Y., Best Paper Award (3rd Prize), International Conference of Vision and Eye Research 2017, KB Woo Fund. 2017.

Tsang K., Wong S.Y., Yao K.M., Chan B.P. and Lo A.C.Y., Young Investigator Award for the Oral Category, 12th International Symposium on Healthy Aginh, Research Cnetre of Heart, Brain, Hormone & Healthy Aging, The University of Hong Kong. 2017.

Tsang K.K., Wong S.Y., Yao K.M., Chan B.P., Lai J.S.M., Shih K.C. and Lo A.C.Y., A dox-terminable cell-encapsulating device for intravitreal drug delivery, Hong Kong Ophthalmological Symposium 2016.

Tsang K.K., Wong S.Y., Yao K.M., Chan B.P. and Lo A.C.Y., ARVO-Asia 2017 Travel Grant, ARVO-Asia . 2017.

Tsang K.K., Wong S.Y., Yao K.M., Chan B.P. and Lo A.C.Y., Biocompatibility and stability of doxycycline-terminable intraocular drug delivery cell-encapsulating device, ARVO 2017 Annual Meeting. 2017.

Tsang K.K., Wong S.Y., Yao K.M., Chan B.P. and Lo A.C.Y., Doxycycline-terminable intraocular drug delivery hydrogel, 12th International Symposium on Healthy Aging: “Wellness and Longevity: From Science to Service”. 2017.

Tsang K.K., Wong S.Y., Yao K.M., Chan B.P. and Lo A.C.Y., Doxycycline-terminable intraocular encapsulated-cell device, ARVO-Asia 2017 Meeting. 2017.

Tsang K.K., Wong S.Y., Yao K.M., Chan B.P. and Lo A.C.Y., Intraocular drug delivery device terminable by Doxycycline, International Conference of Vision & Eye Research 2017.

Researcher : Yeung PKK

Project Title:	The Effectiveness of Vasopressin V1 receptor antagonist , SR49059, and V2 Receptor Anatongist, OPC-31260, on Cerebral Edema Formation in Endothelin-1-Overexpressed Mice
Investigator(s):	Yeung PKK, Chung SK
Department:	Anatomy
Source(s) of Funding:	Small Project Funding
Start Date:	09/2008

List of Research Outputs

LI L., Yeung P.K.K. and Chung S.K., Dopamine Transporter (DAT)-expressing Cells Specific CR6-interacting Factor 1 (DATCrif1) Knockout Mice as an Experimental Animal Model for Study the Pathogenesis and Discovery of Novel Treatment of Parkinson’s Disease, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

Ng C.L., Cheng O.Y., JIAN M., Kwan S.C., Ho W.L., Cheng K.Y., Yeung P.K.K., Zhou L., Hoo R.L.C., Chung S.K., Xu A., Lam K.S.L. and Chan K.H., Chronic adiponectin deficiency leads to Alzheimer’s disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice, Molecular Neurodegeneration. 2016, 11: 71-87.

TAM S.W., Lau K.W.W., Yeung P.K.K., Law A.C.K. and Chung S.K., Endothelin-1 induced cofilin rod formation in hippocampal neurons via endothelin type B receptor and NADPH oxidase-mediated oxidative stress pathway, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Yeung P.K.K., Lai A.K.W., Son H.J., Zhang X., Hwang O., Chung S.S.M. and Chung S.K., Aldose reductase deficiency leads to oxidative stress-induced dopaminergic neuronal loss and autophagic abnormality in an animal model of Parkinson's disease, Neurobiology of Aging. 2017, 50: 119-133.

Zhou L., Ma S.L., Yeung P.K.K., Wong Y.H., Tsim K.W.K., Lam L.C.W. and Chung S.K., Anxiety and depression with neurogenesis defects in exchange protein directly activated by cAMP 2-deficient mice are ameliorated by a selective serotonin reuptake inhibitor, Prozac, Translational Psychiatry. 2016.

Researcher : Yip MS

List of Research Outputs

QIN Y., Ng R.K., Ng T.W., Tong K.K., Au Y.K., Niu B., Tan Z., Yip M.S., Wang J.J., Sham P.C. and Cheah K.S.E., Genome-wide identification of active enhancers in the developing mouse nucleus pulposus, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : Yip YL

List of Research Outputs

Jia L.J., Tsang C.M., Yip Y.L., ZHANG J., Deng W. and Tsao G.S.W., Establishment and characterization of immortalized nasopharyngeal epithelial cells with stable infection of Epstein-Barr virus, 4th International Anatomical Sciences & Cell Biology Conference. 2016.

Jia L.J., Tsang C.M., Yip Y.L., Law W.T., ZHANG J., Deng W. and Tsao G.S.W., Establishment and characterization of immortalized nasopharyngeal epithelial cells with stable infection of Epstein-Barr virus, AMPK 2016: New Mechanism and Physiology. 2016.

Jia L.J., ZHANG J., Yip Y.L., Lin W., Jin D., Tsang C.M. and Tsao G.S.W., Hypoxia induces lytic reactivation of Epstein-Barr virus in stable M81-infected nasopharyngeal epithelial cells, Keystone Symposia Conference on Tumor Metabolism: Mechanisms and Targets. 2017.

Tsao G.S.W., ZHANG J., Jia L.J., Tsang C.M., Lin W., Yip Y.L., Deng W., Lo K.W. and Lung M.L., The role of EBV infection in aerobic glycolysis in nasopharyngeal carcinoma., AACR Annual Meeting 2017.

XU W., Li B., Guan X., Chung S.K., Yang W., Yip Y.L., Law S.Y.K., Chan K.T., Lee N.P.Y., Chan K.W., Xu L.Y., Li E.M., Tsao G.S.W., He Q.Y. and Cheung A., Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression, Nature Communications. 2017, 8: 14399.

ZHANG J., Jia L.J., Lin W., Yip Y.L., LAU V.M.-.Y., Zhu D., Tsang C.M., Zhou Y.L., Deng W., Lung H.L., Lung M.L., Cheung A. and Tsao G.S.W., Epstein-Barr Virus Encoded Latent Membrane Protein-1 Induces Glucose Transporter-1 Transcription is Dependent on the mTORC1 Mediated NF-κB Pathway Activation, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

ZHANG J., Jia L.J., Lin W., Yip Y.L., Lo K.W., LAU V.M.-.Y., Zhu D., Tsang C.M., Zhou Y., Deng W., Lung H.L., Lung M.L., Cheung L.M. and Tsao G.S.W., Epstein-barr Virus-encoded Latent Membrane Protein 1 Upregulates Glucose Transporter 1 Transcription Via The Mtorc1/nf-κb Signaling Pathways, Journal of Virology. 2017, 91: e02168-16.

Researcher : Yu B

Project Title:	Virus-like particle (VLP)-based mucosal vaccine for inducing cross-serotype immunity against Streptococcus pneumoniae infection
Investigator(s):	Yu B, Huang J, Ho PL
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2017

List of Research Outputs

FENG Z., Yu B. and Huang J., RNAi-effecting vector construction in “obligate” anaerobic Salmonella strain YB1 as a potentially competent payload in cancer treatment, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Ning B.T., Yu B., Chan S., Chan J.L., Huang J. and Chan G.C.F., Treatment of Neuroblastoma with an Engineered “Obligate” Anaerobic Salmonella typhimurium Strain YB1, Journal of Cancer. 2017, 8(9): 1609–1618.

Shi L., Yu B., Cai C.H. and Huang J., Angiogenic inhibitors delivered by the type III secretion system of tumor-targeting Salmonella typhimurium safely shrink tumors in mice, AMB Express. 2016, 6.

XU C., LIN Q., DENG J., Yu B., ARYA S. and Huang J., Live attenuated Salmonella-based Vaccines delivering SaEsxA by Type III Secretion System Confer Protection against Staphylococcus aureus Infection, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

ZHANG B., Cai J., Yu B., HUA Y., Lau C.Y., Kao R.Y.T., Sze K.H., Yuen K.Y. and Huang J., A DNA vaccine targeting TcdA and TcdB induces protective immunity against Clostridium difficile, BMC Infectious Diseases. 2016, 16.

Researcher : Yu C

Project Title:	Down-regulation of integrin-beta3 by clathrin-mediated endocytosis
Investigator(s):	Yu C
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	11/2014
Completion Date:	10/2016

Project Title:	Investigating phosphatidylinositol lipid signaling at the cancer invadosome
Investigator(s):	Yu C
Department:	School of Biomedical Sciences
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	09/2015

Project Title:	The mechanism of Cdc42 regulation in podosome assembly
Investigator(s):	Yu C
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2016

Project Title:	Induction of cancer cell apoptosis by integrin endocytosis
Investigator(s):	Yu C
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Mini Grant
Start Date:	05/2017

Project Title:	(1) Cellular Dynamics: Membrane-Cytoskeleton Interface Meeting, and (2) Seminar in Nanoscience Initiative at CUNY; (1) Myosin1e orchestrates phosphatidylinositol signaling at the ventral layer of podosomes/(2) Matrix microenvironment modulates force-dependent adhesion signaling of integrin receptors
Investigator(s):	Yu C
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2017
Completion Date:	05/2017

Project Title:	Investigating the functional role of spatial-temporal activation of myosin-II in invadopodia disassembly
Investigator(s):	Yu C
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

List of Research Outputs

CAO F., Tsao G.S.W. and Yu C., Regulation of Integrin beta3 Endocytosis at the Podosome, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

Rafiq N.B., Lieu Z.Z., Jiang T., Yu C., Matsudaira P., Gareth J.E. and Bershadsky A.D., Podosome assembly is controlled by the GTPase ARF1 and its nucleotide exchange factor ARNO, The Journal of Cell Biology. 2017, 216: 181-197.

Yu C., Ligand mobility triggers adhesion transformation and podosome formation, Tissue Engineering and Regenerative Medicine International Society-Asia Pacific Meeting 2016. 2016.

Yu C., Matrix microenvironment modulates force-dependent adhesion signaling of integrin receptors, Seminar in the Advanced Science Research Center, The City University of New York, USA. 2017.

Yu C., Mechano-transduction of integrin signaling and podosome formation, The 4th International Anatomical Sciences & Cell Biology Conference 2016. 2016.

Yu C., Mechano-transduction of integrin signaling, Young investigator symposium of matrix biology, Shenzhen University. 2016.

Yu C., Mechano-transduction, adhesion signaling and endocytosis of integrin-beta3, The 2nd National Conference of Chinese Society of Matrix Biology (CSMB), Jishou, Hunan, China, June7th-9th, 2017,. 2017.

Yu C., Research Output Prize of 2016, Strategic Research Theme on Development & Reproduction, The University of Hong Kong. 2017.

Yu C., Spatial-temporal Regulation of Podosome Formation and Integrin Signaling, Seminar in the Institute of Biomedical Engineering, National Taiwan University. 2016.

Yu C., Spatial-temporal regulation of integrin activation, PI3K signaling, and podosome formation, Seminar in School of Life Science, Northwestern Polytechnical University, China. 2016.

ZHOU Y., Zhang Y.G., CAO F., SIT H.M., Tsao G.S.W. and Yu C., Define the Functional Role of Myosin-1e at the Macrophage Podosome, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

Researcher : Yuen KS

List of Research Outputs

. S., Yuen K.S., WONG N.H.M., CHENG T.F., Botelho M.G. and Jin D., CRISPR/Cas9 targeting of viral essential genes suppresses Epstein- Barr virus DNA load in nasopharyngeal carcinoma cells of latency II., The American Society for Virology 36th Annual Meeting, University of Wisconsin-Madison, Madison, Wisconsin, USA, June 23-28, 2017.. 2017.

CHAUDHARY V., Zhang S., Yuen K.S., Li D., Kok K.H., Liang M. and Jin D., Differential modulation of type I and type II interferon signaling by severe fever-with-thrombocytopenia syndrome virus NSs protein., 2016 World Life Science Conference. Beijing, China, 2016.

CHAUDHARY V., Yuen K.S., Chan J.F.W., Chan C.P., Kok K.H., Chan C.P., Yuen K.Y. and Jin D., Selective activation of interferon-γ signaling by Zika virus NS5 protein (invited speaker)., 2016 World Life Science Conference.. Beijing, China, 2016.

CHAUDHARY V., Zhang S., Yuen K.S., Li D., Liang M.F. and Jin D., Severe fever-with-thrombocytopenia syndrome virus NSs protein exerts opposite regulatory roles on type I and type II interferon signaling., The American Society for Virology 36th Annual Meeting, University of Wisconsin-Madison, Madison, Wisconsin, USA, June 23-28, 2017.. 2017.

CHAUDHARY V., Yuen K.S., Chan J.F.W., Chan C.P., Wang F., Kok K.H., Chan C.P., Yuen K.Y. and Jin D., Zika virus NS5 protein differentially modulates type I and type II interferon signaling., Cross Street Immunology Conference, National Taiwan University, Taipei, March 18-19, 2017.. 2017.

Chaudhary V., Yuen K.S., Chan J.F.W., Chan C.P., Wang F., Cai J., Zhang S., Liang M., Kok K.H., Chan C.P., Yuen K.Y. and Jin D., Selective activation of type II interferon signaling by Zika virus NS5 protein, J Virol. 2017, 91(14): e00163-17.

Jin D., CHAUDHARY V., Yuen K.S., Chan J.F.W., Chan C.P. and Yuen K.Y., Zika virus NS5 protein suppresses type I and type III interferon signaling but augments type II interferon signaling., The American Society for Virology 36th Annual Meeting, University of Wisconsin-Madison, Madison, Wisconsin, USA, June 23-28, 2017.. 2017.

WONG N.H.M., Yuen K.S., Chan C.P. and Jin D., Suppression of IFN-β production by Epstein-Barr virus lytic transactivator Zta., Immunology 2017 – The American Association of Immunologists Meeting, Walter E. Washington Convention Center, Washington, D.C., USA, May 12-16, 2017.. 2017.

Yuen K.S., WONG N.H.M. and Jin D., CRISPR/Cas9-facilitated construction of a bacterial artificial chromosome clone of Epstein-Barr virus from C666-1 nasopharyngeal carcinoma cells., 17th International Symposium on Epstein Barr Virus and Associated Diseases (EBV2016). Zurich, Switzerland, 2016.

Yuen K.S., Chan C.P., Kok K.H. and Jin D., Mutagenesis and genome engineering of Epstein-Barr virus in cultured human cells by CRISPR/Cas9., Methods in Molecular Biology. 2016, 1498: 23-31.

Yuen K.S., Wang Z.M., WONG N.H.M., Zhang Z.Q., CHENG T.F., LUI W.Y., Chan C.P. and Jin D., Suppression of Epstein-Barr virus DNA load in latently infected nasopharyngeal carcinoma cells by CRISPR/Cas9, Virus Res.. 2017.

Yuen K.S., WONG N.H.M. and Jin D., Suppression of Epstein-Barr virus infection in nasopharyngeal carcinoma cells through CRISPR/Cas9 targeting of EBNA1, OriP and W repeats, In: Christian Münz, 17th International Symposium on EBV and associated diseases. 2016.

Researcher : ZHANG H

List of Research Outputs

Sze K.H., Lam W.H., Zhang H., Ke Y., Tse M.K., Woo P.C.Y., Lau S.K.P., Lau C.Y., Cai J., Tung E.T., Lo R.K., Xu S., Kao R.Y.T., Hao Q. and Yuen K.Y., Talaromyces marneffei Mp1p Is a Virulence Factor that Binds and Sequesters a Key Proinflammatory Lipid to Dampen Host Innate Immune Response, Cell Chemical Biology. 2017, 24: 182-194.

WANG L., ZHANG H., Wong Y.M.E. and Sham M.H., The role of Notch signalling during mouse craniofacial development, 18th International Congress of Developmental Biology. 2017.

WANG L., Zhang H. and Sham M.H., The role of Notch signalling during mouse pharyngeal arch development, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Woo P.C.Y., Lau S.K.P., Lau C.Y., Tung T.K., Chong T.K., Yang F., Zhang H., Lo K.C., Cai J., Au Yeung K.H.R., Ng W.F., Tse H., Wong S.S.Y., Xu S., Lam W.H., Tse M.K., Sze K.H., Kao R.Y.T., Reiner N.E., Hao Q. and Yuen K.Y., Mp1p Is a Virulence Factor in Talaromyces (Penicillium) marneffei, PLOS Neglected Tropical Diseases. 2016, 10: e0004907.

Researcher : ZHANG J

List of Research Outputs

Jia L.J., Tsang C.M., Yip Y.L., ZHANG J., Deng W. and Tsao G.S.W., Establishment and characterization of immortalized nasopharyngeal epithelial cells with stable infection of Epstein-Barr virus, 4th International Anatomical Sciences & Cell Biology Conference. 2016.

Jia L.J., Tsang C.M., Yip Y.L., Law W.T., ZHANG J., Deng W. and Tsao G.S.W., Establishment and characterization of immortalized nasopharyngeal epithelial cells with stable infection of Epstein-Barr virus, AMPK 2016: New Mechanism and Physiology. 2016.

Jia L.J., ZHANG J., Yip Y.L., Lin W., Jin D., Tsang C.M. and Tsao G.S.W., Hypoxia induces lytic reactivation of Epstein-Barr virus in stable M81-infected nasopharyngeal epithelial cells, Keystone Symposia Conference on Tumor Metabolism: Mechanisms and Targets. 2017.

Tsao G.S.W., ZHANG J., Jia L.J., Tsang C.M., Lin W., Yip Y.L., Deng W., Lo K.W. and Lung M.L., The role of EBV infection in aerobic glycolysis in nasopharyngeal carcinoma., AACR Annual Meeting 2017.

ZHANG J., Jia L.J., Lin W., Yip Y.L., LAU V.M.-.Y., Zhu D., Tsang C.M., Zhou Y.L., Deng W., Lung H.L., Lung M.L., Cheung A. and Tsao G.S.W., Epstein-Barr Virus Encoded Latent Membrane Protein-1 Induces Glucose Transporter-1 Transcription is Dependent on the mTORC1 Mediated NF-κB Pathway Activation, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

ZHANG J., Jia L.J., Lin W., Yip Y.L., Lo K.W., LAU V.M.-.Y., Zhu D., Tsang C.M., Zhou Y., Deng W., Lung H.L., Lung M.L., Cheung L.M. and Tsao G.S.W., Epstein-barr Virus-encoded Latent Membrane Protein 1 Upregulates Glucose Transporter 1 Transcription Via The Mtorc1/nf-κb Signaling Pathways, Journal of Virology. 2017, 91: e02168-16.

Researcher : ZHANG S

List of Research Outputs

CHAUDHARY V., ZHANG S., LI D., LIANG M., Kok K.H. and Jin D., Dual regulatory effects of SFTS virus NSs protein on interferon signaling, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

ZHANG S., Membrane Type-1 Matrix Metalloproteinase (MT1-MMP) In the Regulation of Klotho and Wnt Signaling (PhD Thesis), The University of Hong Kong. 2016.

Researcher : ZHANG W

List of Research Outputs

ZHANG W., The Role of Uhrf1 Ring domain in B cell Differentiation and Apoptosis (MPhil Thesis), The University of Hong Kong. 2017.

Researcher : ZHANG Y

List of Research Outputs

ZHANG Y., Intervertebral Disc Maintenance and Repair Potential in Mice (PhD Thesis), The University of Hong Kong. 2017.

Researcher : ZHANG Z

List of Research Outputs

YU Z., TANG L.F., WANG J., Bao S., SHIEH J.T., LEUNG A.W.L., Gao F., ZHANG Z., WONG S.Y.Y., HUI A.L.C., Dung W.F., ZHANG Z., Fan Y., Wong S.M., Sham P.C., AZHAR A., KWOK P.Y., TAM P.P.L., Lian Q. and Cheah K.S.E., Hnrnpa1 Mutations Cause Congenital Heart Defects, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : ZHOU N

List of Research Outputs

ZHOU N., ZHAO Y.F., AGNESE C., Tanner J.A., ADRIAN D. and Huang J., Synthetic Multicellular Systems for Spontaneous Pattern Formation, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : ZHOU Y

List of Research Outputs

Li S.K., Tang H.C., Lau P.Y., Zhou Y. and Ching Y.P., HBx oncoprotein induces chromosome instability in hepatocarcinogenesis via dysregulation of putative tumor suppressor, TAX1BP2, Health Research Symposium 2017.

Xu Y.M., Gao Y.M., Wu D.D., Yu F.Y., Zang Z.S., Yang L., Yao Y., Cai N.L., Zhou Y., Chiu J.F., Ching Y.P. and Lau A.T., Aberrant cytokine secretion and zinc uptake in chronic cadmium-exposed lung epithelial cells, PROTEOMICS - Clinical Applications. 2017, 11: 1600059.

ZHANG J., Jia L.J., Lin W., Yip Y.L., Lo K.W., LAU V.M.-.Y., Zhu D., Tsang C.M., Zhou Y., Deng W., Lung H.L., Lung M.L., Cheung L.M. and Tsao G.S.W., Epstein-barr Virus-encoded Latent Membrane Protein 1 Upregulates Glucose Transporter 1 Transcription Via The Mtorc1/nf-κb Signaling Pathways, Journal of Virology. 2017, 91: e02168-16.

ZHOU Y., Zhang Y.G., CAO F., SIT H.M., Tsao G.S.W. and Yu C., Define the Functional Role of Myosin-1e at the Macrophage Podosome, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

Researcher : ZHU D

List of Research Outputs

ZHANG J., Jia L.J., Lin W., Yip Y.L., LAU V.M.-.Y., Zhu D., Tsang C.M., Zhou Y.L., Deng W., Lung H.L., Lung M.L., Cheung A. and Tsao G.S.W., Epstein-Barr Virus Encoded Latent Membrane Protein-1 Induces Glucose Transporter-1 Transcription is Dependent on the mTORC1 Mediated NF-κB Pathway Activation, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

ZHANG J., Jia L.J., Lin W., Yip Y.L., Lo K.W., LAU V.M.-.Y., Zhu D., Tsang C.M., Zhou Y., Deng W., Lung H.L., Lung M.L., Cheung L.M. and Tsao G.S.W., Epstein-barr Virus-encoded Latent Membrane Protein 1 Upregulates Glucose Transporter 1 Transcription Via The Mtorc1/nf-κb Signaling Pathways, Journal of Virology. 2017, 91: e02168-16.

ZHU D., The role of NF-kB activation in immortalization of human nasopharyngeal epithelial cells, PhD thesis, The University of Hong Kong. 2016.

Researcher : ZHU S

List of Research Outputs

ZHU S. and Chen J., Bacterial Killing of Cultured Pig Tracheal Epithelia was not Altered by HCO3--Free Medium, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

Researcher : Zhang H

List of Research Outputs

WANG L., ZHANG H., Wong Y.M.E. and Sham M.H., The role of Notch signalling during mouse craniofacial development, 18th International Congress of Developmental Biology. 2017.

WANG L., Zhang H. and Sham M.H., The role of Notch signalling during mouse pharyngeal arch development, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : Zheng F

List of Research Outputs

LI T., Zheng F., Cheung M.C.H., WANG F. and Fu C., Fission yeast mitochondria are distributed by dynamic microtubules in a motor-independent manner, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Researcher : Zhou L

Project Title:	American Association for Cancer Research Annual Meeting 2017; PRMT6-Dependent CRAF/ERK Signaling Regulates Cancer Stem Cell Plasticity in Liver Cancer
Investigator(s):	Zhou L
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2017
Completion Date:	04/2017

Project Title:	Establishment and applications of organoid cultures from primary hepatic carcinomas - a pilot study
Investigator(s):	Zhou L, Ma SKY, Yan HHN, Man K, Lo CM
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Mini Grant
Start Date:	04/2017

List of Research Outputs

Ng C.L., Cheng O.Y., JIAN M., Kwan S.C., Ho W.L., Cheng K.Y., Yeung P.K.K., Zhou L., Hoo R.L.C., Chung S.K., Xu A., Lam K.S.L. and Chan K.H., Chronic adiponectin deficiency leads to Alzheimer’s disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice, Molecular Neurodegeneration. 2016, 11: 71-87.

Zhou L., Ma S.L., Yeung P.K.K., Wong Y.H., Tsim K.W.K., Lam L.C.W. and Chung S.K., Anxiety and depression with neurogenesis defects in exchange protein directly activated by cAMP 2-deficient mice are ameliorated by a selective serotonin reuptake inhibitor, Prozac, Translational Psychiatry. 2016.

Researcher : Zhou Y

List of Research Outputs

Researcher : Zhou YL

List of Research Outputs

ZHANG J., Jia L.J., Lin W., Yip Y.L., LAU V.M.-.Y., Zhu D., Tsang C.M., Zhou Y.L., Deng W., Lung H.L., Lung M.L., Cheung A. and Tsao G.S.W., Epstein-Barr Virus Encoded Latent Membrane Protein-1 Induces Glucose Transporter-1 Transcription is Dependent on the mTORC1 Mediated NF-κB Pathway Activation, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

Researcher : Zhou Z

Project Title:	Understanding the regulation of MT1-MMP activity in tumorigenesis
Investigator(s):	Zhou Z
Department:	Biochemistry
Source(s) of Funding:	Matching Fund for NSFC Young Researcher Award
Start Date:	05/2006

Project Title:	Screening anti-ageing substances in small chemical library using premature ageing animals
Investigator(s):	Zhou Z
Department:	School of Biomedical Sciences
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	09/2007

Project Title:	Stem Cells and the Key signaling Pathways in Bone Aging and Regeneration
Investigator(s):	Zhou Z
Department:	School of Biomedical Sciences
Source(s) of Funding:	Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:	03/2011

Project Title:	Stem Cell Strategy for Nervous System Disorders
Investigator(s):	Zhou Z
Department:	School of Biomedical Sciences
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	09/2012

Project Title:	MT1-MMP regulates neural stem cells self-renewal and differentiation via Notch signaling
Investigator(s):	Zhou Z, Osorio Da Silva LA
Department:	School of Biomedical Sciences
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2013

Project Title:	MT1-MMP-mediated ADAM15 shedding in angiogenesis
Investigator(s):	Zhou Z
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2013

Project Title:	Interplay between ADAM15 and MT1-MMP in FGF2-induced angiogenesis
Investigator(s):	Zhou Z
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2013
Completion Date:	08/2016

Project Title:	Regulation of Gli Signaling and Basal Cell Carcinoma by UHRF1
Investigator(s):	Zhou Z
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	02/2014

Project Title:	Regulation of heterochromatin remodeling in DNA repair and aging
Investigator(s):	Zhou Z, Hao Q, Chu IK
Department:	School of Biomedical Sciences
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	02/2014

Project Title:	Outstanding Researcher Award 2013-14
Investigator(s):	Zhou Z
Department:	School of Biomedical Sciences
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	12/2014

Project Title:	Lamin A in Chromatin Dynamics and Aging
Investigator(s):	Zhou Z
Department:	School of Biomedical Sciences
Source(s) of Funding:	Croucher Senior Research Fellowships in Natural Sciences, Technology and Medicine
Start Date:	01/2016

Project Title:	SIRT6 in bone marrow stromal cell potency and the development of osteoporosis
Investigator(s):	Zhou Z
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2016

Project Title:	SIRT6 deacetylates p53 to modulate cellular senescence and aging
Investigator(s):	Zhou Z
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2016

List of Research Outputs

CHU T.L., Tsang K.Y., Tsang S.W., Zhou Z. and Cheah K.S.E., MMP14 Regulates Lineage Progression of Hypertrophic Chondrocytes, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016.

CHU T.L., Tsang K.Y., Zhou Z. and Cheah K.S.E., MMP14 and Regulation of the Hypertrophic Chondrocyte to Osteoblast Lineage, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

IEONG I.L., GHOSH S. and Zhou Z., Characterization of KAP1 acetylation and its roles in DNA damage repair, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

LONG F., Osorio Da Silva L.A., WU X. and Zhou Z., ISM1 in mammary gland morphogenesis and its malignant transformation, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

Zhou Z., Chromatin remodeling and epigenetic regulation of aging, 32 RBC Symposium 2016, Kyoto University. 2016.

Zhou Z., Mattrix Matters:Nuclear Lamin A in Chromatin Remodeling, DNA Damage Repair and Aging, 2016 International Conference on Aging Research. Hangzhou, China, 2016.

Zhou Z., Nuclear Lamin A in Chromatin Remodeling, DNA Damage Repair and Aging, Gordon Research Conference Genomic Instability. Hong Kong, 2016.

Zhou Z., Nuclear Lamin in chromatin remodeling and aging, 2016 World Life Science Comference. Beijing, CHINA, 2016.

Zhou Z., Nuclear Matrix in epigenetic regulation and aging, Cell Fate Diversity in Aging Zeng Conference 2016 Croatia. Croatia, 2016.

Zhou Z., SIRT6 targets p53 to regulate DNA damage repair, stem cell maintenance and aging, Genetics of Aging and Life History， Dague, Korean. Korea, 2016.

Zhou Z., Sirtuins in laminopathy-based premature aging, 2016 Translational Medicine Forum of Chinese Geriatology Society, Nanchang, CHINA. Nanchang CHINA, 2016.

Researcher : Zhu D

List of Research Outputs

ZHU D., The role of NF-kB activation in immortalization of human nasopharyngeal epithelial cells, PhD thesis, The University of Hong Kong. 2016.

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