Dept of Microbiology

DEPT OF MICROBIOLOGY

Researcher : Ahmed SS

List of Research Outputs

Lau S.K.P., Ahmed S.S., Yeung C., Li K.S.M., Fan Y.Y., Cheng T.Y., Cai J., Wang M., Zheng B., Wong S.S.Y., Woo P.C.Y. and Yuen K.Y., Identification and interspecies transmission of a novel bocaparvovirus among different bat species in China, The Journal of General Virology. 2016, 97: 3345-3358.

Woo P.C.Y., Teng L.L., BAI R., Wong Y.P., Martelli P., Hui S.W., Tsang K.L., Lau C.Y., Ahmed S.S., Yip C.Y., CHOI K.Y., Li K.S.M., Lam S.F., Lau S.K.P. and Yuen K.Y., High Diversity of Genogroup I Picobirnaviruses in Mammals, Frontier in microbiology. 2016, 7: 1886.

Researcher : BAI R

List of Research Outputs

Woo P.C.Y., Teng L.L., BAI R., Wong Y.P., Martelli P., Hui S.W., Tsang K.L., Lau C.Y., Ahmed S.S., Yip C.Y., CHOI K.Y., Li K.S.M., Lam S.F., Lau S.K.P. and Yuen K.Y., High Diversity of Genogroup I Picobirnaviruses in Mammals, Frontier in microbiology. 2016, 7: 1886.

Woo P.C.Y., Lau S.K.P., Choi G.K.Y., Hunag Y., Sivakumar S., Tsoi H.W., Yip C.C., Jose S.V., BAI R., Wong Y.M., Joesph M., Li T., Wernery U. and Yuen K.Y., Molecular epidemiology of canine picornavirus in Hong Kong and Dubai and proposal of a novel genus in Picornaviridae., Infect Genet Evol.. 2016, 41: 191-200.

Researcher : CHEN P

List of Research Outputs

HUANG X., ZHENG M., Wang P., Mok B.W.Y., LIU S., Lau S.Y., CHEN P., Liu Y., LIU H., CHEN Y., Song W., Yuen K.Y. and Chen H., An NS-segment exonic splicing enhancer regulates influenza A virus replication in mammalian cells, Nature Communications. 2017, 8: 14751.

Researcher : CHEN SMY

List of Research Outputs

WU X., Liu L., Cheung K.W., Wang H., Lu X., Cheung K.L.A., LIU W., Huang X., Li Y., Chen Z., CHEN S.M.Y., Zhang T., Wu H. and Chen Z., Brain Invasion by CD4+ T Cells Infected with a Transmitted/Founder HIV-1BJZS7 During Acute Stage in Humanized Mice, Journal of Neuroimmune Pharmacology. 2016, 11: 572-583.

Researcher : CHEUNG NN

List of Research Outputs

CHEUNG N.N., Lai K.K., Dai J., Kok K.H., Chen H., Chan K.H., Yuen K.Y. and Kao R.Y.T., Broad-spectrum inhibition of common respiratory RNA viruses by a pyrimidine synthesis inhibitor with involvement of the host antiviral response. , Journal of General Virology. 2017.

PANG B., Cheung N.N., ZHANG W., Dai J., Kao R.Y.T., Zhang H. and Hao Q., Structural Characterization of H1N1 Nucleoprotein-Nucleozin Binding Sites, Scientific Reports. 2016, 6: 29684.

Researcher : CHIK KKH

List of Research Outputs

Chan C.M., Chu H., Zhang J., Leung L.H., Sze K.H., Kao R.Y.T., Chik K.K.H., To K.K.W., Chan J.F.W., Chen H., Jin D., Liu L. and Yuen K.Y., Hemagglutinin of influenza A virus binds specifically to cell surface nucleolin and plays a role in virus internalization, Virology. 2016, 494: 78-88.

Chan J.F.W., Zhang J., Chan C.S., Yip C.Y., Mak W.N., Zhu H., Poon K.M., Tee K.M., Zhu Z., Cai J., Tsang O.L., Chik K.K.H., Yin F., Chan K.H., Kok K.H., Jin D., Au Yeung K.H.R. and Yuen K.Y., Characterization of a novel mouse model for Zika virus infection using dexamethasone-immunosuppressed mice, First International Conference on Zika Virus. 2017.

Chan J.F.W., Chan K.H., Yuan S., CHIK K.K.H., ZHU Z., Tee K.M., TSANG O.L., Yip C.Y., Poon K.M., Chan C.S., Mak W.N., Zhang J. and Yuen K.Y., Development of an in ovo system for evaluation of antivirals against Zika virus, 30th International Conference on Antiviral Research (ICAR). 2017.

Chan J.F.W., Yip C.Y., Tsang O.L., Tee K.M., Cai J., Chik K.K.H., Zhu Z., Chan C.S., CHOI K.Y., Sridhar S., Zhang J., Lu G., Chiu K., Lo A.C.Y., Tsao G.S.W., Kok K.H., Jin D., Chan K.H. and Yuen K.Y., Differential cell line susceptibility to the emerging Zika virus: implications for disease pathogenesis, non-vector-borne human transmission and animal reservoirs, Emerging Microbes & Infections. 2016, 5: e93.

Chan J.F.W., CHIK K.K.H., Yuan S., Kao R.Y.T. and Yuen K.Y., Identification of bromocriptine as a Zika virus NS2B-NS3 protease inhibitor, American Society for Virology (ASV) 36th Annual Meeting. 2017.

Chan J.F.W., Yip C.Y., Tee K.M., Zhu Z., Tsang O.L., Chik K.K.H., TSANG G.W.T., Chan C.S., Poon K.M., Sridhar S., Yin F., Hung F.N.I., Chau S.K.Y., Zhang J., Chan K.H. and Yuen K.Y., Improved detection of Zika virus RNA in human and animal specimens by a novel, highly sensitive and specific real-time RT-PCR assay targeting the 5′-untranslated region of Zika virus, Tropical Medicine & International Health. 2017, 22: 594-603.

Chan J.F.W., CHIK K.K.H., Yuan S., Yip C.Y., ZHU Z., Tee K.M., TSANG O.L., Chan C.S., Poon K.M., Lu G., Zhang J., Lai K.K., Chan K.H., Kao R.Y.T. and Yuen K.Y., Novel antiviral activity and mechanism of bromocriptine as a Zika virus NS2B-NS3 protease inhibitor, Antiviral Research. 2017, 141: 29-37.

Chan J.F.W., Zhang J., Chan C.S., Yip C.Y., Mak W.N., Zhu H., Poon K.M., Tee K.M., Zhu Z., Cai J., Tsang O.L., Chik K.K.H., Yin F., Chan K.H., Kok K.H., Jin D., Au Yeung K.H.R. and Yuen K.Y., Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons, EBioMedicine. 2016, 14: 112-122.

Yip C.Y., Tee K.M., Zhu Z., Chik K.K.H., Tsang O.L., Poon K.M., Chan C.S., Zhang J., Chan K.H., Yuen K.Y. and Chan J.F.W., Development and evaluation of a novel real-time RT-PCR assay targeting the envelope gene of the African and Asian/American lineages of the emerging Zika virus, 3rd Microbiology Asia Congress. 2016.

Yip C.Y., Tee K.M., ZHU Z., TSANG O.L., CHIK K.K.H., TSANG G.W.T., Chan C.S., Poon K.M., Sridhar S., Yin F., Hung F.N.I., Chau S.K.Y., Zhang J., Chan K.H., Yuen K.Y. and Chan J.F.W., Improved detection of Zika virus RNA in human and animal specimens by a novel, highly sensitive and specific real-time RT-PCR assay targeting the 5'-untranslated region of Zika virus, 33rd ASM Clinical Virology Symposium. 2017.

Researcher : CHOI KY

List of Research Outputs

Chan J.F.W., Yip C.Y., Tsang O.L., Tee K.M., Cai J., Chik K.K.H., Zhu Z., Chan C.S., CHOI K.Y., Sridhar S., Zhang J., Lu G., Chiu K., Lo A.C.Y., Tsao G.S.W., Kok K.H., Jin D., Chan K.H. and Yuen K.Y., Differential cell line susceptibility to the emerging Zika virus: implications for disease pathogenesis, non-vector-borne human transmission and animal reservoirs, Emerging Microbes & Infections. 2016, 5: e93.

Chan J.F.W., Tee K.M., CHOI K.Y., Zhu Z., Poon W.S.R., Ng K.T.P., Chan K.H., Hung F.N.I., Man K. and Yuen K.Y., First detection and complete genome sequence of a phylogenetically distinct human polyomavirus 6 highly prevalent in human bile samples, Journal of Infection. 2017, 74: 50-59.

Woo P.C.Y., Teng L.L., BAI R., Wong Y.P., Martelli P., Hui S.W., Tsang K.L., Lau C.Y., Ahmed S.S., Yip C.Y., CHOI K.Y., Li K.S.M., Lam S.F., Lau S.K.P. and Yuen K.Y., High Diversity of Genogroup I Picobirnaviruses in Mammals, Frontier in microbiology. 2016, 7: 1886.

Researcher : Cai J

List of Research Outputs

Chan J.F.W., Zhang J., Chan C.S., Yip C.Y., Mak W.N., Zhu H., Poon K.M., Tee K.M., Zhu Z., Cai J., Tsang O.L., Chik K.K.H., Yin F., Chan K.H., Kok K.H., Jin D., Au Yeung K.H.R. and Yuen K.Y., Characterization of a novel mouse model for Zika virus infection using dexamethasone-immunosuppressed mice, First International Conference on Zika Virus. 2017.

Chan J.F.W., Yip C.Y., Tsang O.L., Tee K.M., Cai J., Chik K.K.H., Zhu Z., Chan C.S., CHOI K.Y., Sridhar S., Zhang J., Lu G., Chiu K., Lo A.C.Y., Tsao G.S.W., Kok K.H., Jin D., Chan K.H. and Yuen K.Y., Differential cell line susceptibility to the emerging Zika virus: implications for disease pathogenesis, non-vector-borne human transmission and animal reservoirs, Emerging Microbes & Infections. 2016, 5: e93.

Chan J.F.W., Zhang J., Chan C.S., Yip C.Y., Mak W.N., Zhu H., Poon K.M., Tee K.M., Zhu Z., Cai J., Tsang O.L., Chik K.K.H., Yin F., Chan K.H., Kok K.H., Jin D., Au Yeung K.H.R. and Yuen K.Y., Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons, EBioMedicine. 2016, 14: 112-122.

Chaudhary V., Yuen K.S., Chan J.F.W., Chan C.P., Wang F., Cai J., Zhang S., Liang M., Kok K.H., Chan C.P., Yuen K.Y. and Jin D., Selective activation of type II interferon signaling by Zika virus NS5 protein, J Virol. 2017, 91(14): e00163-17.

Lau S.K.P., Yeung C., Li K.S.M., Lam S.F., Cai J., Yuen M.C., Wang M., Zheng B., Woo P.C.Y. and Yuen K.Y., Identification and genomic characterization of a novel rat bocavirus from brown rats in China, Infection, Genetics and Evolution. 2017, 47: 68-76.

Lau S.K.P., Ahmed S.S., Yeung C., Li K.S.M., Fan Y.Y., Cheng T.Y., Cai J., Wang M., Zheng B., Wong S.S.Y., Woo P.C.Y. and Yuen K.Y., Identification and interspecies transmission of a novel bocaparvovirus among different bat species in China, The Journal of General Virology. 2016, 97: 3345-3358.

Sze K.H., Lam W.H., Zhang H., Ke Y., Tse M.K., Woo P.C.Y., Lau S.K.P., Lau C.Y., Cai J., Tung E.T., Lo R.K., Xu S., Kao R.Y.T., Hao Q. and Yuen K.Y., Talaromyces marneffei Mp1p Is a Virulence Factor that Binds and Sequesters a Key Proinflammatory Lipid to Dampen Host Innate Immune Response, Cell Chemical Biology. 2017, 24: 182-194.

Woo P.C.Y., Lau S.K.P., Lau C.Y., Tung T.K., Chong T.K., Yang F., Zhang H., Lo K.C., Cai J., Au Yeung K.H.R., Ng W.F., Tse H., Wong S.S.Y., Xu S., Lam W.H., Tse M.K., Sze K.H., Kao R.Y.T., Reiner N.E., Hao Q. and Yuen K.Y., Mp1p Is a Virulence Factor in Talaromyces (Penicillium) marneffei, PLOS Neglected Tropical Diseases. 2016, 10: e0004907.

ZHANG B., Cai J., Yu B., HUA Y., Lau C.Y., Kao R.Y.T., Sze K.H., Yuen K.Y. and Huang J., A DNA vaccine targeting TcdA and TcdB induces protective immunity against Clostridium difficile, BMC Infectious Diseases. 2016, 16.

Researcher : Chan CM

List of Research Outputs

Chan C.M., Chu H., Wang Y., Wong H.Y.B., Zhao X., Zhou J., Yang D., Leung A.S.P., Chan J.F.W., Yeung M.L., Yan J., Lu G., Gao G.F. and Yuen K.Y., Carcinoembryonic Antigen-related Cell Adhesion Molecule 5 (CEACAM5) Is an Important Surface Attachment Factor Facilitating the Entry of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV), Journal of Virology. 2016, JVI.01133-16.

Chan C.M., Chu H., Zhang J., Leung L.H., Sze K.H., Kao R.Y.T., Chik K.K.H., To K.K.W., Chan J.F.W., Chen H., Jin D., Liu L. and Yuen K.Y., Hemagglutinin of influenza A virus binds specifically to cell surface nucleolin and plays a role in virus internalization, Virology. 2016, 494: 78-88.

Researcher : Chan CS

List of Research Outputs

Chan J.F.W., Zhang J., Chan C.S., Yip C.Y., Mak W.N., Zhu H., Poon K.M., Tee K.M., Zhu Z., Cai J., Tsang O.L., Chik K.K.H., Yin F., Chan K.H., Kok K.H., Jin D., Au Yeung K.H.R. and Yuen K.Y., Characterization of a novel mouse model for Zika virus infection using dexamethasone-immunosuppressed mice, First International Conference on Zika Virus. 2017.

Chan J.F.W., Chan K.H., Yuan S., CHIK K.K.H., ZHU Z., Tee K.M., TSANG O.L., Yip C.Y., Poon K.M., Chan C.S., Mak W.N., Zhang J. and Yuen K.Y., Development of an in ovo system for evaluation of antivirals against Zika virus, 30th International Conference on Antiviral Research (ICAR). 2017.

Chan J.F.W., Yip C.Y., Tsang O.L., Tee K.M., Cai J., Chik K.K.H., Zhu Z., Chan C.S., CHOI K.Y., Sridhar S., Zhang J., Lu G., Chiu K., Lo A.C.Y., Tsao G.S.W., Kok K.H., Jin D., Chan K.H. and Yuen K.Y., Differential cell line susceptibility to the emerging Zika virus: implications for disease pathogenesis, non-vector-borne human transmission and animal reservoirs, Emerging Microbes & Infections. 2016, 5: e93.

Chan J.F.W., Yip C.Y., Tee K.M., Zhu Z., Tsang O.L., Chik K.K.H., TSANG G.W.T., Chan C.S., Poon K.M., Sridhar S., Yin F., Hung F.N.I., Chau S.K.Y., Zhang J., Chan K.H. and Yuen K.Y., Improved detection of Zika virus RNA in human and animal specimens by a novel, highly sensitive and specific real-time RT-PCR assay targeting the 5′-untranslated region of Zika virus, Tropical Medicine & International Health. 2017, 22: 594-603.

Chan J.F.W., CHIK K.K.H., Yuan S., Yip C.Y., ZHU Z., Tee K.M., TSANG O.L., Chan C.S., Poon K.M., Lu G., Zhang J., Lai K.K., Chan K.H., Kao R.Y.T. and Yuen K.Y., Novel antiviral activity and mechanism of bromocriptine as a Zika virus NS2B-NS3 protease inhibitor, Antiviral Research. 2017, 141: 29-37.

Chan J.F.W., Zhang J., Chan C.S., Yip C.Y., Mak W.N., Zhu H., Poon K.M., Tee K.M., Zhu Z., Cai J., Tsang O.L., Chik K.K.H., Yin F., Chan K.H., Kok K.H., Jin D., Au Yeung K.H.R. and Yuen K.Y., Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons, EBioMedicine. 2016, 14: 112-122.

Yip C.Y., Tee K.M., Zhu Z., Chik K.K.H., Tsang O.L., Poon K.M., Chan C.S., Zhang J., Chan K.H., Yuen K.Y. and Chan J.F.W., Development and evaluation of a novel real-time RT-PCR assay targeting the envelope gene of the African and Asian/American lineages of the emerging Zika virus, 3rd Microbiology Asia Congress. 2016.

Yip C.Y., Tee K.M., ZHU Z., TSANG O.L., CHIK K.K.H., TSANG G.W.T., Chan C.S., Poon K.M., Sridhar S., Yin F., Hung F.N.I., Chau S.K.Y., Zhang J., Chan K.H., Yuen K.Y. and Chan J.F.W., Improved detection of Zika virus RNA in human and animal specimens by a novel, highly sensitive and specific real-time RT-PCR assay targeting the 5'-untranslated region of Zika virus, 33rd ASM Clinical Virology Symposium. 2017.

Researcher : Chan E

List of Research Outputs

Xiong L., Yang Y., Ye Y.N., Teng L.L., Chan E., Watt R.M., Guo F.B., Lau S.K.P. and Woo P.C.Y., Laribacter hongkongensis anaerobic adaptation mediated by arginine metabolism is controlled by the cooperation of FNR and ArgR, Environmental Microbiology. 2017, 19: 1266-1280.

Researcher : Chan JFW

Project Title:	Epidemiology, seroprevalence, and clinical manifestations of immunodeficiency due to autoantibody against interferon gamma in Hong Kong
Investigator(s):	Chan JFW, Hung FNI
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Mini Grant
Start Date:	01/2014
Completion Date:	09/2016

Project Title:	Characterization and determination of animal reservoirs of a novel animal flavivirus.
Investigator(s):	Chan JFW, Yuen KY
Department:	Microbiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

Project Title:	Efficacy and mechanistic evaluation of banana lectin (BanLec) as a novel pan-coronavirus antiviral agent: in-vitro and ex-vivo evidence
Investigator(s):	Chan JFW, Yeung ML, Chan KH
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2016

Project Title:	Commissioned Study on Conducting Tests for Zika Virus among Asymptomatic People Returning from the 2016 Olympic Games and Paralympic Games
Investigator(s):	Chan JFW, Hung FNI, Yuen KY
Department:	Microbiology
Source(s) of Funding:	Commissioned Research on Mental Health Policy and Services
Start Date:	08/2016

Project Title:	First International Conference on Zika Virus; Characterization of a novel mouse model for Zika virus infection using dexamethasone-immunosuppressed mice
Investigator(s):	Chan JFW
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	02/2017
Completion Date:	02/2017

Project Title:	Repurposing clinically approved drugs as immediately available treatment options for the emerging Zika virus infection
Investigator(s):	Chan JFW, Yuan S
Department:	Microbiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2017

List of Research Outputs

CHAUDHARY V., Yuen K.S., Chan J.F.W., Chan C.P., Kok K.H., Chan C.P., Yuen K.Y. and Jin D., Selective activation of interferon-γ signaling by Zika virus NS5 protein (invited speaker)., 2016 World Life Science Conference.. Beijing, China, 2016.

CHAUDHARY V., Yuen K.S., Chan J.F.W., Chan C.P., Wang F., Kok K.H., Chan C.P., Yuen K.Y. and Jin D., Zika virus NS5 protein differentially modulates type I and type II interferon signaling., Cross Street Immunology Conference, National Taiwan University, Taipei, March 18-19, 2017.. 2017.

Chan C.M., Chu H., Wang Y., Wong H.Y.B., Zhao X., Zhou J., Yang D., Leung A.S.P., Chan J.F.W., Yeung M.L., Yan J., Lu G., Gao G.F. and Yuen K.Y., Carcinoembryonic Antigen-related Cell Adhesion Molecule 5 (CEACAM5) Is an Important Surface Attachment Factor Facilitating the Entry of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV), Journal of Virology. 2016, JVI.01133-16.

Chan C.M., Chu H., Zhang J., Leung L.H., Sze K.H., Kao R.Y.T., Chik K.K.H., To K.K.W., Chan J.F.W., Chen H., Jin D., Liu L. and Yuen K.Y., Hemagglutinin of influenza A virus binds specifically to cell surface nucleolin and plays a role in virus internalization, Virology. 2016, 494: 78-88.

Chan G.C.W., Mok M.M.Y., Hung L.L., Chan J.F.W., Kwan L.P.Y., Ma M.K.M., Yap Y.H.D. and Tang S.C.W., Mycobacterium chlorophenolicum: An uncommon cause of peritonitis in a peritoneal dialysis patient., Nephrology (Carlton). 2017, 22(6): 498-499.

Chan J.F.W., ASM Young Ambassador of Science, American Society for Microbiology. 2017.

Chan J.F.W., Antiviral Therapy for Emerging Infectious Diseases with Focus on Middle East Respiratory Syndrome, 2016 海峡两岸暨港澳精准医疗协同创新论坛, Shenzhen, China. 2016.

Chan J.F.W., Associate Editor, BMC Microbiology. 2017.

Chan J.F.W., Zhang J., Chan C.S., Yip C.Y., Mak W.N., Zhu H., Poon K.M., Tee K.M., Zhu Z., Cai J., Tsang O.L., Chik K.K.H., Yin F., Chan K.H., Kok K.H., Jin D., Au Yeung K.H.R. and Yuen K.Y., Characterization of a novel mouse model for Zika virus infection using dexamethasone-immunosuppressed mice, First International Conference on Zika Virus. 2017.

Chan J.F.W., Control and prevention of Zika virus infection: the Hong Kong experience, Shenzhen Medical Association Hospital Infection Control Committee Annual Scientific Meeting (2016), Shenzhen, China. 2016.

Chan J.F.W., Chan K.H., Yuan S., CHIK K.K.H., ZHU Z., Tee K.M., TSANG O.L., Yip C.Y., Poon K.M., Chan C.S., Mak W.N., Zhang J. and Yuen K.Y., Development of an in ovo system for evaluation of antivirals against Zika virus, 30th International Conference on Antiviral Research (ICAR). 2017.

Chan J.F.W., Yip C.Y., Tsang O.L., Tee K.M., Cai J., Chik K.K.H., Zhu Z., Chan C.S., CHOI K.Y., Sridhar S., Zhang J., Lu G., Chiu K., Lo A.C.Y., Tsao G.S.W., Kok K.H., Jin D., Chan K.H. and Yuen K.Y., Differential cell line susceptibility to the emerging Zika virus: implications for disease pathogenesis, non-vector-borne human transmission and animal reservoirs, Emerging Microbes & Infections. 2016, 5: e93.

Chan J.F.W., Choi G.K.Y., Leung S.S.M., Tee K.M., Tang S.F., Hung F.N.I. and Yuen K.Y., Epidemiological and clinical characteristics of patients with anti-interferon-gamma autoantibodies associated with opportunistic infections in Hong Kong, European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 2017.

Chan J.F.W., Choi G.K.Y., Leung S.S.M., Tee K.M., Tang S.F., Hung F.N.I. and Yuen K.Y., Epidemiology, Seroprevalence, and Clinical Manifestations of Immunodeficiency due to Autoantibody Against Interferon Gamma in Hong Kong, Health Research Symposium 2017 (Health and Medical Research Fund). 2017.

Chan J.F.W., Tee K.M., CHOI K.Y., Zhu Z., Poon W.S.R., Ng K.T.P., Chan K.H., Hung F.N.I., Man K. and Yuen K.Y., First detection and complete genome sequence of a phylogenetically distinct human polyomavirus 6 highly prevalent in human bile samples, Journal of Infection. 2017, 74: 50-59.

Chan J.F.W., CHIK K.K.H., Yuan S., Kao R.Y.T. and Yuen K.Y., Identification of bromocriptine as a Zika virus NS2B-NS3 protease inhibitor, American Society for Virology (ASV) 36th Annual Meeting. 2017.

Chan J.F.W., Yip C.Y., Tee K.M., Zhu Z., Tsang O.L., Chik K.K.H., TSANG G.W.T., Chan C.S., Poon K.M., Sridhar S., Yin F., Hung F.N.I., Chau S.K.Y., Zhang J., Chan K.H. and Yuen K.Y., Improved detection of Zika virus RNA in human and animal specimens by a novel, highly sensitive and specific real-time RT-PCR assay targeting the 5′-untranslated region of Zika virus, Tropical Medicine & International Health. 2017, 22: 594-603.

Chan J.F.W., CHIK K.K.H., Yuan S., Yip C.Y., ZHU Z., Tee K.M., TSANG O.L., Chan C.S., Poon K.M., Lu G., Zhang J., Lai K.K., Chan K.H., Kao R.Y.T. and Yuen K.Y., Novel antiviral activity and mechanism of bromocriptine as a Zika virus NS2B-NS3 protease inhibitor, Antiviral Research. 2017, 141: 29-37.

Chan J.F.W., Outbreak investigation of an unusual hospital-acquired infection: a practical approach, The 9th Annual Scientific Symposium of the Infection Control Association of Macao, Macao. 2016.

Chan J.F.W., Rapid response research to emerging epidemic arboviral diseases: Zika virus infection, 2017 International Conference on Dengue and Dengue Prevention, National Health Research Institute, Taiwan. 2017.

Chan J.F.W., Yip C.Y., Ho T.Y., Chan K.H., Hung F.N.I. and Yuen K.Y., Surveillance for Zika virus infection among asymptomatic returning travelers from the Rio Olympic and Paralymic Games, 33rd ASM Clinical Virology Symposium. 2017.

Chan J.F.W., Sridhar S., Yip C.Y., Lau S.K.P. and Woo P.C.Y., The role of laboratory diagnostics in emerging viral infections: the example of the Middle East respiratory syndrome epidemic, Journal of Microbiology. 2017, 55: 172-182.

Chan J.F.W., Top 1% scholar (2016), Thomas Reuters Essential Science Indicators. 2016.

Chan J.F.W., Zhang J., Chan C.S., Yip C.Y., Mak W.N., Zhu H., Poon K.M., Tee K.M., Zhu Z., Cai J., Tsang O.L., Chik K.K.H., Yin F., Chan K.H., Kok K.H., Jin D., Au Yeung K.H.R. and Yuen K.Y., Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons, EBioMedicine. 2016, 14: 112-122.

Chan J.F.W., Zika Virus:What Clinicians Should Know, The 336th and 337th Hong Kong Doctors Union Sunday Afternoon Symposium, Hong Kong. 2016.

Chaudhary V., Yuen K.S., Chan J.F.W., Chan C.P., Wang F., Cai J., Zhang S., Liang M., Kok K.H., Chan C.P., Yuen K.Y. and Jin D., Selective activation of type II interferon signaling by Zika virus NS5 protein, J Virol. 2017, 91(14): e00163-17.

Chen H.K.J., Lam H.Y., Yip C.Y., Wong S.C.Y., Chan J.F.W., Ma E.S., Cheng V.C.C., Tang S.F. and Yuen K.Y., Clinical Evaluation of the New High-Throughput Luminex NxTAG Respiratory Pathogen Panel Assay for Multiplex Respiratory Pathogen Detection, Journal of Clinical Microbiology. 2016, 54: 1820-1825.

Hung F.N.I., To K.K.W., Chan J.F.W., Cheng C.C.V., Liu S.H.K., Tam A., Chan T.C.I., Zhang J., Li P.C.K., Wong T.L., ZHANG R., Cheung M.K.S., Leung W., Lau J.Y., Fok M., Chen H., Chan K.H. and Yuen K.Y., Efficacy of Clarithromycin-Naproxen-Oseltamivir Combination in the Treatment of Patients Hospitalized for Influenza A(H3N2) Infection: an open-label, randomized controlled, phase 2b/3 trial., Chest. 2017, 151: 1069-1080.

Hung F.N.I., Zhang J., To K.K.W., Chan J.F.W., ZHU H., ZHANG R., Chan T.C.I., Chan K.H. and Yuen K.Y., Unexpectedly Higher Morbidity and Mortality of Hospitalized Elderly Patients Associated with Rhinovirus Compared with Influenza Virus Respiratory Tract Infection, International Journal of Molecular Sciences. 2017, 18: 259.

Jin D., CHAUDHARY V., Yuen K.S., Chan J.F.W., Chan C.P. and Yuen K.Y., Zika virus NS5 protein suppresses type I and type III interferon signaling but augments type II interferon signaling., The American Society for Virology 36th Annual Meeting, University of Wisconsin-Madison, Madison, Wisconsin, USA, June 23-28, 2017.. 2017.

Lau S.K.P., Chan J.F.W., Hung F.N.I., Cheng V.C.C., Sridhar S., Yip C.Y., Chan K.H. and Woo P.C.Y., Middle East Respiratory Syndrome Interpreted: Human Herpesvirus 6B Pneumonia, The American Journal of Medicine. 2016, 129(9): 945-7.

TSANG C.C., Chan J.F.W., Pong W.M., Chen H.K.J., Ngan A.H.Y., Cheung M., Lai C.K.C., Tsang D.N.C., Lau S.K.P. and Woo P.C.Y., Cutaneous hyalohyphomycosis due to Parengyodontium album gen. et comb. nov. , Medical Mycology. 2016, 54: 699-713.

TSANG C.C., Xiong L., Poon W.S.R., Chen H.K.J., Leung K.W., Lam J.Y.W., Wu K.L.A., Chan J.F.W., Lau S.K.P. and Woo P.C.Y., Gordonia hongkongensis sp. nov., isolated from blood culture and peritoneal dialysis effluent of patients in Hong Kong, International Journal of Systematic and Evolutionary Microbiology. 2016, 66: 3942-3950.

Thu N.T.M., Chan J.F.W., Hien H.T.A., Tung N.L.N., Thanh N.T.T., Day J., Chau N.V.V., Thwaites G., Woo P.C.Y., Yuen K.Y. and Le T., Clinical Performance of the Mp1p Immunoassay for Rapid Diagnosis of Talaromyces marneffei Infection, Conference on Retroviruses and Opportunistic Infections. 2017.

Yap Y.H.D., Chan J.F.W., Yip T., Mok M.M., Kwan L., Lo W.K. and Chan D.T.M., Burkholderia Cepacia Exit-site infection in peritoneal dialysis patients - clinical characteristics and treatment outcomes, Peritoneal Dialysis International. 2016, 36(4): 390-394.

Yip C.Y., Tee K.M., Zhu Z., Chik K.K.H., Tsang O.L., Poon K.M., Chan C.S., Zhang J., Chan K.H., Yuen K.Y. and Chan J.F.W., Development and evaluation of a novel real-time RT-PCR assay targeting the envelope gene of the African and Asian/American lineages of the emerging Zika virus, 3rd Microbiology Asia Congress. 2016.

Yip C.Y., Lo J.Y.C., Sridhar S., Lung D.C., Luk S., Chan K.H., Chan J.F.W., Cheng C.C.V., Woo P.C.Y., Yuen K.Y. and Lau S.K.P., First Report of a Fatal Case Associated with EV-D68 Infection in Hong Kong and Emergence of an Interclade Recombinant in China Revealed by Genome Analysis, International Journal of Molecular Sciences. 2017, 18: e1065.

Yip C.Y., Tee K.M., ZHU Z., TSANG O.L., CHIK K.K.H., TSANG G.W.T., Chan C.S., Poon K.M., Sridhar S., Yin F., Hung F.N.I., Chau S.K.Y., Zhang J., Chan K.H., Yuen K.Y. and Chan J.F.W., Improved detection of Zika virus RNA in human and animal specimens by a novel, highly sensitive and specific real-time RT-PCR assay targeting the 5'-untranslated region of Zika virus, 33rd ASM Clinical Virology Symposium. 2017.

Researcher : Chan KH

Project Title:	19th Annual Meeting at the European Society for Clinical Virology Lisbon, Portugal, 14-17 September 2016; Comparing performance of NxTAG RPP, xTAG RVP Fast v2 and FilmArray RP for detecting respiratory pathogens in nasopharyngeal aspirates and swine/avian origin influenza A in culture isolates
Investigator(s):	Chan KH
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2016
Completion Date:	09/2016

List of Research Outputs

CHEUNG N.N., Lai K.K., Dai J., Kok K.H., Chen H., Chan K.H., Yuen K.Y. and Kao R.Y.T., Broad-spectrum inhibition of common respiratory RNA viruses by a pyrimidine synthesis inhibitor with involvement of the host antiviral response. , Journal of General Virology. 2017.

Cao P., Wong C.M., Chan K.H., Wang X., Chan K.P., Peiris J.S.M., Poon L.M.L. and Yang L., Age-specific genetic and antigenic variations of influenza A viruses in Hong Kong, 2013–2014, Scientific Reports. 2016, 6: 30260.

Chan J.F.W., Zhang J., Chan C.S., Yip C.Y., Mak W.N., Zhu H., Poon K.M., Tee K.M., Zhu Z., Cai J., Tsang O.L., Chik K.K.H., Yin F., Chan K.H., Kok K.H., Jin D., Au Yeung K.H.R. and Yuen K.Y., Characterization of a novel mouse model for Zika virus infection using dexamethasone-immunosuppressed mice, First International Conference on Zika Virus. 2017.

Chan J.F.W., Chan K.H., Yuan S., CHIK K.K.H., ZHU Z., Tee K.M., TSANG O.L., Yip C.Y., Poon K.M., Chan C.S., Mak W.N., Zhang J. and Yuen K.Y., Development of an in ovo system for evaluation of antivirals against Zika virus, 30th International Conference on Antiviral Research (ICAR). 2017.

Chan J.F.W., Yip C.Y., Tsang O.L., Tee K.M., Cai J., Chik K.K.H., Zhu Z., Chan C.S., CHOI K.Y., Sridhar S., Zhang J., Lu G., Chiu K., Lo A.C.Y., Tsao G.S.W., Kok K.H., Jin D., Chan K.H. and Yuen K.Y., Differential cell line susceptibility to the emerging Zika virus: implications for disease pathogenesis, non-vector-borne human transmission and animal reservoirs, Emerging Microbes & Infections. 2016, 5: e93.

Chan J.F.W., Tee K.M., CHOI K.Y., Zhu Z., Poon W.S.R., Ng K.T.P., Chan K.H., Hung F.N.I., Man K. and Yuen K.Y., First detection and complete genome sequence of a phylogenetically distinct human polyomavirus 6 highly prevalent in human bile samples, Journal of Infection. 2017, 74: 50-59.

Chan J.F.W., Yip C.Y., Tee K.M., Zhu Z., Tsang O.L., Chik K.K.H., TSANG G.W.T., Chan C.S., Poon K.M., Sridhar S., Yin F., Hung F.N.I., Chau S.K.Y., Zhang J., Chan K.H. and Yuen K.Y., Improved detection of Zika virus RNA in human and animal specimens by a novel, highly sensitive and specific real-time RT-PCR assay targeting the 5′-untranslated region of Zika virus, Tropical Medicine & International Health. 2017, 22: 594-603.

Chan J.F.W., CHIK K.K.H., Yuan S., Yip C.Y., ZHU Z., Tee K.M., TSANG O.L., Chan C.S., Poon K.M., Lu G., Zhang J., Lai K.K., Chan K.H., Kao R.Y.T. and Yuen K.Y., Novel antiviral activity and mechanism of bromocriptine as a Zika virus NS2B-NS3 protease inhibitor, Antiviral Research. 2017, 141: 29-37.

Chan J.F.W., Yip C.Y., Ho T.Y., Chan K.H., Hung F.N.I. and Yuen K.Y., Surveillance for Zika virus infection among asymptomatic returning travelers from the Rio Olympic and Paralymic Games, 33rd ASM Clinical Virology Symposium. 2017.

Chan J.F.W., Zhang J., Chan C.S., Yip C.Y., Mak W.N., Zhu H., Poon K.M., Tee K.M., Zhu Z., Cai J., Tsang O.L., Chik K.K.H., Yin F., Chan K.H., Kok K.H., Jin D., Au Yeung K.H.R. and Yuen K.Y., Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons, EBioMedicine. 2016, 14: 112-122.

Chen Y., Chan K.H., Hong C., Kang Y., Ge S., Chen H., Wong Y.M., Joseph S., Patteril N.G., Wernery U., Xia N., Lau S.K.P. and Woo P.C.Y., A highly specific rapid antigen detection assay for on-site diagnosis of MERS., Journal of Infection. 2016, 73: 82-84.

Cowling B.J., Chan K.H., Chu K.W., Fang J., Fung R.O.P., So H.C., Seto W.H., Ip D.K.M., Peiris J.S.M. and Cowling B.J., Diagnostic performance of the Sofia Analyzer in outpatient clinics, Options IX for The Control of Influenza, Chicago. 2016.

Hung F.N.I., To K.K.W., Chan J.F.W., Cheng C.C.V., Liu S.H.K., Tam A., Chan T.C.I., Zhang J., Li P.C.K., Wong T.L., ZHANG R., Cheung M.K.S., Leung W., Lau J.Y., Fok M., Chen H., Chan K.H. and Yuen K.Y., Efficacy of Clarithromycin-Naproxen-Oseltamivir Combination in the Treatment of Patients Hospitalized for Influenza A(H3N2) Infection: an open-label, randomized controlled, phase 2b/3 trial., Chest. 2017, 151: 1069-1080.

Hung F.N.I., Zhang J., To K.K.W., Chan J.F.W., ZHU H., ZHANG R., Chan T.C.I., Chan K.H. and Yuen K.Y., Unexpectedly Higher Morbidity and Mortality of Hospitalized Elderly Patients Associated with Rhinovirus Compared with Influenza Virus Respiratory Tract Infection, International Journal of Molecular Sciences. 2017, 18: 259.

Ip D.K.M., Lau L.L., Leung N.H.L., Fang J., Chan K.H., Chu K.W., Leung G.M., Peiris J.S.M., Uyeki T.M. and Cowling B.J., Viral shedding and transmission potential of asymptomatic and pauci-symptomatic influenza virus infections in the community, Clinical Infectious Diseases. 2016, 64(6): 736-742.

Lau S.K.P., Woo P.C.Y., Li K.S.M., Zhang H.J., Fan Y.Y., Zhang J., Chan B.C., Lam S.F., Yip C.Y., Yuen M.C., Chan K.H., Chen Z. and Yuen K.Y., Identification of Novel Rosavirus Species That Infects Diverse Rodent Species and Causes Multisystemic Dissemination in Mouse Model, PLoS Pathogen. 2016, 12: e1005911.

Lau S.K.P., Chan J.F.W., Hung F.N.I., Cheng V.C.C., Sridhar S., Yip C.Y., Chan K.H. and Woo P.C.Y., Middle East Respiratory Syndrome Interpreted: Human Herpesvirus 6B Pneumonia, The American Journal of Medicine. 2016, 129(9): 945-7.

Lau S.K.P., Wernery R., Wong Y.M., Joseph S., Tsang K.L., Patteril N.A., Elizabeth S.K., Chan K.H., Muhammed R., Kinne J., Yuen K.Y., Wernery U. and Woo P.C.Y., Polyphyletic origin of MERS coronaviruses and isolation of a novel clade A strain from dromedary camels in the United Arab Emirates, Emerging Microbes and Infections. 2016, 5: e128.

Lau S.Y., Joseph S., Chan K.H., Chen H., Patteril N.A., Elizabeth S.K., Muhammed R., Baskar V., Lau S.K.P., Kinne J., Wernery U. and Woo P.C.Y., Complete Genome Sequence of Influenza Virus H9N2 Associated with a Fatal Outbreak among Chickens in Dubai., Genome Announcement. 2016, 4: e00752-16.

Leung N.H.L., Chan K.H., Chu K.W., Fang J., Fung R.O.P., So H.C., Seto W.H., Ip D.K.M., Peiris J.S.M. and Cowling B.J., Diagnostic performance of the Sofia Analyzer in outpatient clinics., Options for the Control of Influenza IX, Chicago, USA, Aug 24-28, 2016. . 2016.

To K.K.W., Lu L., Yip C.Y., Poon W.S.R., Fung A.M.Y., Cheng A., Lui D.H.K., Ho T.Y., Hung F.N.I., Chan K.H. and Yuen K.Y., Additional molecular testing of saliva specimens improves the detection of respiratory viruses, Emerging Microbes & Infections. 2017, 6: e49.

Tsang K.L., Fang J., Chan K.H., Ip D.K.M., Leung G.M., Peiris J.S.M., Cowling B.J. and Cauchemez S.T., Individual correlates of infectivity of influenza A virus infections in households , Options for the Control of Influenza IX, Chicago, USA, Aug 24-28, 2016.. 2016.

Xu C., Fang J., Perera R.A.P.M., Kam M.S., Ng S., Chan Y.H., Chan K.H., Ip D.K.M., Peiris J.S.M. and Cowling B.J., Serum 25-Hydroxyvitamin D was not associated with influenza virus infection in children and adults in Hong Kong, 2009-2010, Journal of Nutrition. 2016, 146(12): 2506-12.

Yip C.Y., Tee K.M., Zhu Z., Chik K.K.H., Tsang O.L., Poon K.M., Chan C.S., Zhang J., Chan K.H., Yuen K.Y. and Chan J.F.W., Development and evaluation of a novel real-time RT-PCR assay targeting the envelope gene of the African and Asian/American lineages of the emerging Zika virus, 3rd Microbiology Asia Congress. 2016.

Yip C.Y., Lo J.Y.C., Sridhar S., Lung D.C., Luk S., Chan K.H., Chan J.F.W., Cheng C.C.V., Woo P.C.Y., Yuen K.Y. and Lau S.K.P., First Report of a Fatal Case Associated with EV-D68 Infection in Hong Kong and Emergence of an Interclade Recombinant in China Revealed by Genome Analysis, International Journal of Molecular Sciences. 2017, 18: e1065.

Yip C.Y., Tee K.M., ZHU Z., TSANG O.L., CHIK K.K.H., TSANG G.W.T., Chan C.S., Poon K.M., Sridhar S., Yin F., Hung F.N.I., Chau S.K.Y., Zhang J., Chan K.H., Yuen K.Y. and Chan J.F.W., Improved detection of Zika virus RNA in human and animal specimens by a novel, highly sensitive and specific real-time RT-PCR assay targeting the 5'-untranslated region of Zika virus, 33rd ASM Clinical Virology Symposium. 2017.

Zhang J., Sze D., Yung B., Tang P., Chen W., Chan K.H. and Leung P., Distinct expression of interferon-induced protein with tetratricopeptide repeats (IFIT) 1/2/3 and other antiviral genes between subsets of dendritic cells induced by dengue virus 2 infection, Immunology. 2016, 148: 363-376.

Researcher : Chan WM

List of Research Outputs

To K.K.W., Chan W.M., Li K.S.M., Lam S.F., Chen Z., Tse H., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., High prevalence of four novel astrovirus genotype species identified from rodents in China, Journal of General Virology. 2017, 98: 1004-1015.

Researcher : Chen H

Project Title:	Modification of cells for isolation and characterization of SARS CoV from animal sources
Investigator(s):	Chen H
Department:	Microbiology
Source(s) of Funding:	Seed Funding for New Staff
Start Date:	07/2004

Project Title:	Biological function/relevance for the 29 nucleotides insertion in the genome of animal SARS like CoV
Investigator(s):	Chen H, Guan Y
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Project Title:	Antiviral drug resistance in H5N1 virus
Investigator(s):	Chen H, Guan Y
Department:	Microbiology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2007

Project Title:	The role of RAP55 and P-bodies in the regulation of influenza virus replication
Investigator(s):	Chen H
Department:	Microbiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014

Project Title:	Adaptive strategies of the H7N9 virus PB2 polymerase for replication in humans
Investigator(s):	Chen H
Department:	Microbiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	Options IX for the Control of Influenza Conference; Characterization of mutations associated with cold adapted properties in DelNS1 influenza viruses: potential for new live attenuated influenza vaccine development
Investigator(s):	Chen H
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2016
Completion Date:	08/2016

Project Title:	Study on regulation of expression of EBV BARTs and function of BART LncRNAs in nasopharyngeal carcinoma cells
Investigator(s):	Chen H
Department:	Microbiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2017

List of Research Outputs

CHEUNG N.N., Lai K.K., Dai J., Kok K.H., Chen H., Chan K.H., Yuen K.Y. and Kao R.Y.T., Broad-spectrum inhibition of common respiratory RNA viruses by a pyrimidine synthesis inhibitor with involvement of the host antiviral response. , Journal of General Virology. 2017.

Chan C.M., Chu H., Zhang J., Leung L.H., Sze K.H., Kao R.Y.T., Chik K.K.H., To K.K.W., Chan J.F.W., Chen H., Jin D., Liu L. and Yuen K.Y., Hemagglutinin of influenza A virus binds specifically to cell surface nucleolin and plays a role in virus internalization, Virology. 2016, 494: 78-88.

Chan C.P., Yuen C.K.J., Fung S.Y., CHEUNG P.H.H., Chen H., Kok K.H. and Jin D., Antiviral activity of double-stranded RNA-binding protein PACT against influenza A virus mediated through suppression of viral RNA polymerase, FOCIS 2017.

Chen H., Verhoeven R., TONG S. and Mok B.W.Y., Epstein-Barr virus BART noncoding RNAs modulate host gene expression for virus latency leading to oncogenesis in epithelial cells, AACR annual meeting . 2017.

Chen H., In: Hayward virus and cancer symposium, Johns Hopkins University School of Medicine, Functions of Epstein-Barr virus BART non-coding RNAs for virus latency and oncogenesis in epithelial cells. 2016.

Chen H., Functions of Epstein-Barr virus BART non-coding RNAs for virus latency and oncogenesis in epithelial cells, Hayward virus and cancer symposium, Johns Hopkins University School of Medicine. 2016.

Chen H., Influenza virus NS1 interacts with Trim27 leading to aberrant cytokine expression, Hong Kong Society of Immunology 2016 Annual General Meeting and Scientific Meeting. 2016.

Chen J., Yang K., Zhang M., Shen C., Chen J., Wang G., Huang S., Zhang M., Xiong H., Chen H., Chen Y. and Xia N., Rapid identification of imported influenza viruses at Xiamen International Airport via an active surveillance program, Clinical Microbiology and Infection. The Netherlands, Elsevier, 2017, S1198-743X(17): 30288-4.

Chen Y., Chan K.H., Hong C., Kang Y., Ge S., Chen H., Wong Y.M., Joseph S., Patteril N.G., Wernery U., Xia N., Lau S.K.P. and Woo P.C.Y., A highly specific rapid antigen detection assay for on-site diagnosis of MERS., Journal of Infection. 2016, 73: 82-84.

HUANG X., ZHENG M., Wang P., Mok B.W.Y., LIU S., Lau S.Y., CHEN P., Liu Y., LIU H., CHEN Y., Song W., Yuen K.Y. and Chen H., An NS-segment exonic splicing enhancer regulates influenza A virus replication in mammalian cells, Nature Communications. 2017, 8: 14751.

Hung F.N.I., To K.K.W., Chan J.F.W., Cheng C.C.V., Liu S.H.K., Tam A., Chan T.C.I., Zhang J., Li P.C.K., Wong T.L., ZHANG R., Cheung M.K.S., Leung W., Lau J.Y., Fok M., Chen H., Chan K.H. and Yuen K.Y., Efficacy of Clarithromycin-Naproxen-Oseltamivir Combination in the Treatment of Patients Hospitalized for Influenza A(H3N2) Infection: an open-label, randomized controlled, phase 2b/3 trial., Chest. 2017, 151: 1069-1080.

Jiang W., Wang S., Chen H., Ren H., Huang X., Wang G., Chen Z., Chen L., Chen Z. and Zhou P., A Bivalent Heterologous DNA Virus-Like-Particle Prime-Boost Vaccine Elicits Broad Protection against both Group 1 and 2 Influenza A Viruses, Journal of Virology. USA, American Society for Microbiology, 2017, 91: e02052-16.

Lau S.Y., Joseph S., Chan K.H., Chen H., Patteril N.A., Elizabeth S.K., Muhammed R., Baskar V., Lau S.K.P., Kinne J., Wernery U. and Woo P.C.Y., Complete Genome Sequence of Influenza Virus H9N2 Associated with a Fatal Outbreak among Chickens in Dubai., Genome Announcement. 2016, 4: e00752-16.

Ou H., Yao W., Wu N., Wang F.X., Weng T., Han C., Lu X., Yu D., Wu H., Cheng L., Chen H., Yao H. and Li L., Preclinical evaluation of the safety and pathogenicity of a live attenuated recombinant influenza A/H7N9 seed strain and corresponding MF59-adjuvanted split vaccine, Oncotarget. 2016, 7(49): 81012-81025.

Verhoeven R.J.A., TONG S., Zhang G.H., Zong J.F., Chen Y.X., Jin D., Chen M.R., Pan J.J. and Chen H., NF-κB Signaling Regulates Expression of Epstein-Barr Virus BART MicroRNAs and Long Noncoding RNAs in Nasopharyngeal Carcinoma, Journal of Virology. USA, AMER SOC MICROBIOLOGY, 2016, 90: 6475-6488.

Wang S., Ren H., Jiang W., Chen H., Hu H., Chen Z. and Zhou P., Divergent Requirement of Fc-Fcγ Receptor Interactions for In Vivo Protection against Influenza Viruses by Two Pan-H5 Hemagglutinin Antibodies , Journal of Virology. USA, Amercian Society of Microbiology, 2017, 91: e02065-16.

Xu Y., Zhou L., Zong J., Ye Y., Chen G., Chen Y., Liao X., Guo Q., Qiu S., Lin S., Chen H. and Pan J., Decreased expression of the NKG2D ligand ULBP4 may be an indicator of poor prognosis in patients with nasopharyngeal carcinoma, Oncotarget. 2017, 8(26): 42007-42019.

Zheng M., Wang P., Lau S.Y., HUANG X., Mok B.W.Y., LIU S., LIU H., Liu Y. and Chen H., Characterization of mutations associated with cold adapted properties in DelNS1 influenza viruses; potential for new live attenuated influenza vaccine development , Options IX for The Control of Influenza, Chicago, USA, 24-28 Aug, 2016.

Researcher : Chen HKJ

Project Title:	Molecular epidemiology study of HIV-1 among the men who have sex with men (MSM) population in Hong Kong
Investigator(s):	Chen HKJ, Yam WC
Department:	Microbiology
Source(s) of Funding:	Council for the AIDS Trust Fund - General Award
Start Date:	04/2009

List of Research Outputs

Chen H.K.J., Lam H.Y., Yip C.Y., Wong S.C.Y., Chan J.F.W., Ma E.S., Cheng V.C.C., Tang S.F. and Yuen K.Y., Clinical Evaluation of the New High-Throughput Luminex NxTAG Respiratory Pathogen Panel Assay for Multiplex Respiratory Pathogen Detection, Journal of Clinical Microbiology. 2016, 54: 1820-1825.

Cheng C.C.V., Chen H.K.J., So S.Y.C., Wong C.Y.S., Chau P.H., Wong M.W.L., Ching H.C.R., Ng L.M.M., Lee W.M., Hung F.N.I., Ho P.L. and Yuen K.Y., A novel risk factor associated with colonization by Carbapenemase-Producing Enterobacteriaceae: Use of Proton Pump Inhibitors in addition to Antimicrobial Treatment, Infection Control & Hospital Epidemiology. 2016, 37: 1418-1425.

Cheng C.C.V., Wong S.C., Wong I.W.Y., Chau P.H., So S.Y.C., Wong C.Y.S., Chen H.K.J., Lee W.M., Tai J.W.M., Chau C.H., Lo W.K. and Yuen K.Y., The challenge of patient empowerment in hand hygiene promotion in health care facilities in Hong Kong, American Journal of Infection Control. 2017, 45: 562-565.

TSANG C.C., Chan J.F.W., Pong W.M., Chen H.K.J., Ngan A.H.Y., Cheung M., Lai C.K.C., Tsang D.N.C., Lau S.K.P. and Woo P.C.Y., Cutaneous hyalohyphomycosis due to Parengyodontium album gen. et comb. nov. , Medical Mycology. 2016, 54: 699-713.

TSANG C.C., Xiong L., Poon W.S.R., Chen H.K.J., Leung K.W., Lam J.Y.W., Wu K.L.A., Chan J.F.W., Lau S.K.P. and Woo P.C.Y., Gordonia hongkongensis sp. nov., isolated from blood culture and peritoneal dialysis effluent of patients in Hong Kong, International Journal of Systematic and Evolutionary Microbiology. 2016, 66: 3942-3950.

Wong S.C.Y., Tse H., Chen H.K.J., Cheng V.C.C., Ho P.L. and Yuen K.Y., Colistin-Resistant Enterobacteriaceae Carrying the mcr-1 Gene among Patients in Hong Kong , Emerging Infectious Diseases. 2016, 22: 1667-1669.

Researcher : Chen JHK

Project Title:	Molecular epidemiology study of HIV-1 among the men who have sex with men (MSM) population in Hong Kong
Investigator(s):	Chen HKJ, Yam WC
Department:	Microbiology
Source(s) of Funding:	Council for the AIDS Trust Fund - General Award
Start Date:	04/2009

List of Research Outputs

Researcher : Chen M

Project Title:	Immunogenicity and Cross-Protective Effect of Novel human T cell Epitopes in H5N1 influenza virus nucleoprotein
Investigator(s):	Chen M, Zheng B
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	10/2010

List of Research Outputs

Cheung K.L.A., Huang Y., Chen M. and Chen Z., Human cytomegalovirus latent infection modulates HIV restriction factors in CD34+ hematopoietic stem cells (WEPEA016), AIDS 2016.

Cheung K.L.A., Huang Y., Kwok H.Y., Chen M. and Chen Z., Latent human cytomegalovirus enhances HIV-1 infection in CD34+ progenitor cells, In: Geoffrey Hill, Blood Advances. Washington, DC, USA, The American Society of Hematology, 2017, 1: 306-318.

Researcher : Chen M

List of Research Outputs

Cheung K.L.A., Huang Y., Chen M. and Chen Z., Human cytomegalovirus latent infection modulates HIV restriction factors in CD34+ hematopoietic stem cells (WEPEA016), AIDS 2016.

Researcher : Chen Z

Project Title:	A novel model for the study of lung pathogenesis of SARS
Investigator(s):	Chen Z
Department:	LKS Medical Faculty
Source(s) of Funding:	National Institutes of Health, US Department of Health and Human Services - General Award
Start Date:	08/2007

Project Title:	Understanding the Ongoing HIV Epidemic in Yunnan China
Investigator(s):	Chen Z
Department:	LKS Medical Faculty
Source(s) of Funding:	China AIDS Initiative - General Award
Start Date:	05/2008

Project Title:	Preventing HIV-1 infection using a novel vaccine immunogen
Investigator(s):	Chen Z
Department:	LKS Medical Faculty
Source(s) of Funding:	Global Health Grants
Start Date:	10/2008

Project Title:	Establishment of a rapid, high-throughput, cost-effective HIV-1 drug resistance testing system
Investigator(s):	Chen Z
Department:	Microbiology
Source(s) of Funding:	Council for the AIDS Trust Fund - General Award
Start Date:	05/2011

Project Title:	A Novel Vaccine for Mesothelioma Immunotherapy and Prevention;
Investigator(s):	Chen Z
Department:	Microbiology
Source(s) of Funding:	Pneumoconiosis Compensation Fund Board - General Award
Start Date:	07/2011

Project Title:	AIDS Vaccine 2011 A Novel Vaccine Design for Inducing Robust HIV-1 Specific Immunity
Investigator(s):	Chen Z
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2011

Project Title:	Blocking HIV infection by gene-encoding neutralizing antibodies
Investigator(s):	Chen Z, Liu L
Department:	Microbiology
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2012

Project Title:	AIDS Vaccine 2012; Mucosal Prime with a Replicating Vaccinia-based Vaccine Promotes Mucosal Immunity against SIV.
Investigator(s):	Chen Z
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2012

Project Title:	To Establish a Novel and Rapid Phenotypic HIV-1 Drug Resistance Testing System
Investigator(s):	Chen Z, Liu L, Cheung KW, Du DY
Department:	Microbiology
Source(s) of Funding:	Guangdong-Hong Kong Technology Cooperation Funding Scheme
Start Date:	07/2013

Project Title:	Further optimization of live viral vector for HIV vaccine research
Investigator(s):	Chen Z, Wang H
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	11/2013
Completion Date:	11/2016

Project Title:	To Establish a Novel and Rapid Phenotypic HIV-1 Drug Resistance Testing System
Investigator(s):	Chen Z, Liu L, Cheung KW, Du DY
Department:	Microbiology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	12/2013

Project Title:	Mechanism of potentiating HIV antigen-specific CD8+ T cells
Investigator(s):	Chen Z, Liu L, Yam WC, Cheung KLA, Cheung KW
Department:	Microbiology
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2014

Project Title:	A New Therapeutic Vaccine for HIV/AIDS
Investigator(s):	Chen Z, Cheung KW
Department:	Microbiology
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	12/2014

Project Title:	Role of a newly identified PD-1 isoform in modulating immune responses
Investigator(s):	Chen Z, Cheung KLA
Department:	Microbiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	A New Therapeutic Vaccine for HIV/AIDS
Investigator(s):	Chen Z, Cheung KW
Department:	Microbiology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	03/2015

Project Title:	A novel PDI DNA-based vaccination strategy to mimic Gag-specific responses found in HIV Elite controllers
Investigator(s):	Chen Z
Department:	Microbiology
Source(s) of Funding:	ANR / RGC Joint Research Scheme
Start Date:	04/2015

Project Title:	Role of Δ42PD1 in HIV Infection
Investigator(s):	Chen Z, Cheung KLA
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2015

Project Title:	Induction of Mesothelioma-Specific CD8+ T Cell Response for Immunotherapy and Prevention
Investigator(s):	Chen Z, Man K
Department:	Microbiology
Source(s) of Funding:	Pneumoconiosis Compensation Fund Board - General Award
Start Date:	09/2015

Project Title:	Role of PD1-Based Vaccine-Elicited CD8+ T Lymphocytes in Modulating MDSC-associated Immunosuppression
Investigator(s):	Chen Z, Cheung KLA, Tan Z
Department:	Microbiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016

Project Title:	21st International AIDS Conference (AIDS 2016); Role of myeloid derived suppressive cells on EcoHIV evasion from vaccine induced T cell immune response
Investigator(s):	Chen Z
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2016
Completion Date:	07/2016

Project Title:	A Therapeutic Bi-Specific Neutralizing Antibody for HIV/AIDS
Investigator(s):	Chen Z
Department:	Microbiology
Source(s) of Funding:	Seed Fund for Translational and Applied Research
Start Date:	01/2017

Project Title:	Study on AIDS Vaccine and Immunotherapy
Investigator(s):	Chen Z
Department:	Microbiology
Source(s) of Funding:	醫療衛生三名工程
Start Date:	01/2017

Project Title:	Potency of latency reversing drug combinations for purging HIV-1 reservoir of TGFβ1-induced resting CD4 T cells
Investigator(s):	Chen Z
Department:	Microbiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2017

Project Title:	Induction of Mesothelioma-Specific CD8+ T Cell Response for Immunotherapy and Prevention
Investigator(s):	Chen Z, Man K
Department:	Microbiology
Source(s) of Funding:	Pneumoconiosis Compensation Fund Board - General Award
Start Date:	05/2017

List of Research Outputs

Chen Z., Editorial Board Member Since 2017, AIDS. 2017.

Cheung K.L.A., Huang Y., Chen M. and Chen Z., Human cytomegalovirus latent infection modulates HIV restriction factors in CD34+ hematopoietic stem cells (WEPEA016), AIDS 2016.

Cheung K.L.A., Huang Y., Kwok H.Y., Chen M. and Chen Z., Latent human cytomegalovirus enhances HIV-1 infection in CD34+ progenitor cells, In: Geoffrey Hill, Blood Advances. Washington, DC, USA, The American Society of Hematology, 2017, 1: 306-318.

Jiang W., Wang S., Chen H., Ren H., Huang X., Wang G., Chen Z., Chen L., Chen Z. and Zhou P., A Bivalent Heterologous DNA Virus-Like-Particle Prime-Boost Vaccine Elicits Broad Protection against both Group 1 and 2 Influenza A Viruses, Journal of Virology. USA, American Society for Microbiology, 2017, 91: e02052-16.

Lau S.K.P., Woo P.C.Y., Li K.S.M., Zhang H.J., Fan Y.Y., Zhang J., Chan B.C., Lam S.F., Yip C.Y., Yuen M.C., Chan K.H., Chen Z. and Yuen K.Y., Identification of Novel Rosavirus Species That Infects Diverse Rodent Species and Causes Multisystemic Dissemination in Mouse Model, PLoS Pathogen. 2016, 12: e1005911.

Liu L., Wang H. and Chen Z., Anti-spike IgG exacerbates lung injury by skewing monocyte-macrophage responses during SARS-CoV infection, IMMUNOLOGY 2017.

Liu L., Peng J. and Chen Z., Role of myeloid derived suppressive cells on EcoHIV evasion from vaccine induced T cell immune response. South Africa, International AIDS Conference 2016.

Liu L., Wei Q., Nishiura K., PENG J., Wang H., Midkiff C., Alvarez X., Qin C., Lackner A. and Chen Z., Spatiotemporal interplay of severe acute respiratory syndrome coronavirus and respiratory mucosal cells drives viral dissemination in rhesus macaques, Mucosal Immunology. 2016, 9: 1089-1101.

Tang L., Guo J., Cheng L., Sun C., Liu L., Zuo T., Wang H., Cheng L., Zhang L. and Chen Z., Single N277A substitution in C2 of simian immunodeficiency virus envelope influences vaccine-elicited CD4i neutralizing and anti-V2 antibody responses, Vaccine. 2017, 35: 2582-2591.

Tang X., Jia G., Cheng L., Sun C., Zuo T., Wang H., Chen L., Zhang L. and Chen Z., Single N277A substitution in C2 of simian immunodeficiency virus envelope influences vaccine-elicited CD4i neutralizing and anti-V2 antibody responses. , Vaccine. 2017.

To K.K.W., Chan W.M., Li K.S.M., Lam S.F., Chen Z., Tse H., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., High prevalence of four novel astrovirus genotype species identified from rodents in China, Journal of General Virology. 2017, 98: 1004-1015.

WU X., Liu L., Cheung K.W., Wang H., Lu X., Cheung K.L.A., LIU W., Huang X., Li Y., Chen Z., CHEN S.M.Y., Zhang T., Wu H. and Chen Z., Brain Invasion by CD4+ T Cells Infected with a Transmitted/Founder HIV-1BJZS7 During Acute Stage in Humanized Mice, Journal of Neuroimmune Pharmacology. 2016, 11: 572-583.

Wang S., Ren H., Jiang W., Chen H., Hu H., Chen Z. and Zhou P., Divergent Requirement of Fc-Fcγ Receptor Interactions for In Vivo Protection against Influenza Viruses by Two Pan-H5 Hemagglutinin Antibodies , Journal of Virology. USA, Amercian Society of Microbiology, 2017, 91: e02065-16.

Wei Q., Liu L., Cong Z., Wu X., Wang H., Qin C.H.U.N.-.C.H.U.N.G., Molina P. and Chen Z., Chronic Δ9-Tetrahydrocannabinol Administration Reduces IgE+B Cells but Unlikely Enhances Pathogenic SIVmac251 Infection in Male Rhesus Macaques of Chinese Origin, Journal of Neuroimmune Pharmacology. 2016, 11: 584-591.

Researcher : Chen Z

List of Research Outputs

Chen Z., Editorial Board Member Since 2017, AIDS. 2017.

Cheung K.L.A., Huang Y., Chen M. and Chen Z., Human cytomegalovirus latent infection modulates HIV restriction factors in CD34+ hematopoietic stem cells (WEPEA016), AIDS 2016.

Liu L., Wang H. and Chen Z., Anti-spike IgG exacerbates lung injury by skewing monocyte-macrophage responses during SARS-CoV infection, IMMUNOLOGY 2017.

Liu L., Peng J. and Chen Z., Role of myeloid derived suppressive cells on EcoHIV evasion from vaccine induced T cell immune response. South Africa, International AIDS Conference 2016.

Researcher : Cheng CCV

List of Research Outputs

Cheng C.C.V., Chen H.K.J., So S.Y.C., Wong C.Y.S., Chau P.H., Wong M.W.L., Ching H.C.R., Ng L.M.M., Lee W.M., Hung F.N.I., Ho P.L. and Yuen K.Y., A novel risk factor associated with colonization by Carbapenemase-Producing Enterobacteriaceae: Use of Proton Pump Inhibitors in addition to Antimicrobial Treatment, Infection Control & Hospital Epidemiology. 2016, 37: 1418-1425.

Cheng C.C.V., Wong S.C., Wong I.W.Y., Chau P.H., So S.Y.C., Wong C.Y.S., Chen H.K.J., Lee W.M., Tai J.W.M., Chau C.H., Lo W.K. and Yuen K.Y., The challenge of patient empowerment in hand hygiene promotion in health care facilities in Hong Kong, American Journal of Infection Control. 2017, 45: 562-565.

Hung F.N.I., To K.K.W., Chan J.F.W., Cheng C.C.V., Liu S.H.K., Tam A., Chan T.C.I., Zhang J., Li P.C.K., Wong T.L., ZHANG R., Cheung M.K.S., Leung W., Lau J.Y., Fok M., Chen H., Chan K.H. and Yuen K.Y., Efficacy of Clarithromycin-Naproxen-Oseltamivir Combination in the Treatment of Patients Hospitalized for Influenza A(H3N2) Infection: an open-label, randomized controlled, phase 2b/3 trial., Chest. 2017, 151: 1069-1080.

WANG Y., Lo W.U., Lai R.W., Tsw C.W., Lee R.A., Luk W.K., Cheng C.C.V., Que T.L., Chow K.H. and Ho P.L., IncN ST7 epidemic plasmid carrying bla IMP-4 in Enterobacteriaceae isolates with epidemiological links to multiple geographical areas in China , Journal of Antimicrobial Chemotherapy. 2017, 72: 99-103.

Yip C.Y., Lo J.Y.C., Sridhar S., Lung D.C., Luk S., Chan K.H., Chan J.F.W., Cheng C.C.V., Woo P.C.Y., Yuen K.Y. and Lau S.K.P., First Report of a Fatal Case Associated with EV-D68 Infection in Hong Kong and Emergence of an Interclade Recombinant in China Revealed by Genome Analysis, International Journal of Molecular Sciences. 2017, 18: e1065.

Researcher : Cheng VCC

List of Research Outputs

Chen H.K.J., Lam H.Y., Yip C.Y., Wong S.C.Y., Chan J.F.W., Ma E.S., Cheng V.C.C., Tang S.F. and Yuen K.Y., Clinical Evaluation of the New High-Throughput Luminex NxTAG Respiratory Pathogen Panel Assay for Multiplex Respiratory Pathogen Detection, Journal of Clinical Microbiology. 2016, 54: 1820-1825.

Lau S.K.P., Chan J.F.W., Hung F.N.I., Cheng V.C.C., Sridhar S., Yip C.Y., Chan K.H. and Woo P.C.Y., Middle East Respiratory Syndrome Interpreted: Human Herpesvirus 6B Pneumonia, The American Journal of Medicine. 2016, 129(9): 945-7.

Wong S.C.Y., Tse H., Chen H.K.J., Cheng V.C.C., Ho P.L. and Yuen K.Y., Colistin-Resistant Enterobacteriaceae Carrying the mcr-1 Gene among Patients in Hong Kong , Emerging Infectious Diseases. 2016, 22: 1667-1669.

Researcher : Cheung KLA

Project Title:	Human cytomegalovirus and human immunodeficiency virus type 1 co-infection of CD34+ Myeloid Progenitor Cells
Investigator(s):	Cheung KLA, Chen Z
Department:	LKS Medical Faculty
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2013
Completion Date:	08/2016

Project Title:	Transfer of HIV-1 from HIV-1 latently infected CD34+ hematopoietic progenitors to CD4+ T cells
Investigator(s):	Cheung KLA, Chen Z
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	02/2014
Completion Date:	02/2017

Project Title:	Characterising the role of a novel PD1 isoform expressed on gamma-delta T cells in HIV-1 infection
Investigator(s):	Cheung KLA, Chen Z
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2016

List of Research Outputs

Cheung K.L.A., Huang Y., Chen M. and Chen Z., Human cytomegalovirus latent infection modulates HIV restriction factors in CD34+ hematopoietic stem cells (WEPEA016), AIDS 2016.

Cheung K.L.A., Huang Y., Kwok H.Y., Chen M. and Chen Z., Latent human cytomegalovirus enhances HIV-1 infection in CD34+ progenitor cells, In: Geoffrey Hill, Blood Advances. Washington, DC, USA, The American Society of Hematology, 2017, 1: 306-318.

WU X., Liu L., Cheung K.W., Wang H., Lu X., Cheung K.L.A., LIU W., Huang X., Li Y., Chen Z., CHEN S.M.Y., Zhang T., Wu H. and Chen Z., Brain Invasion by CD4+ T Cells Infected with a Transmitted/Founder HIV-1BJZS7 During Acute Stage in Humanized Mice, Journal of Neuroimmune Pharmacology. 2016, 11: 572-583.

Researcher : Cheung KW

Project Title:	Type of cell death and related mechanisms for gut homing CD4 T cells during human immunodeficiency virus-1 (HIV-1) infection
Investigator(s):	Cheung KW, Chen Z
Department:	LKS Medical Faculty
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2013
Completion Date:	10/2016

List of Research Outputs

WU X., Liu L., Cheung K.W., Wang H., Lu X., Cheung K.L.A., LIU W., Huang X., Li Y., Chen Z., CHEN S.M.Y., Zhang T., Wu H. and Chen Z., Brain Invasion by CD4+ T Cells Infected with a Transmitted/Founder HIV-1BJZS7 During Acute Stage in Humanized Mice, Journal of Neuroimmune Pharmacology. 2016, 11: 572-583.

Researcher : Cheung NN

List of Research Outputs

PANG B., Cheung N.N., ZHANG W., Dai J., Kao R.Y.T., Zhang H. and Hao Q., Structural Characterization of H1N1 Nucleoprotein-Nucleozin Binding Sites, Scientific Reports. 2016, 6: 29684.

Researcher : Chik KKH

List of Research Outputs

Chan J.F.W., Zhang J., Chan C.S., Yip C.Y., Mak W.N., Zhu H., Poon K.M., Tee K.M., Zhu Z., Cai J., Tsang O.L., Chik K.K.H., Yin F., Chan K.H., Kok K.H., Jin D., Au Yeung K.H.R. and Yuen K.Y., Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons, EBioMedicine. 2016, 14: 112-122.

Researcher : Ching HCR

List of Research Outputs

Cheng C.C.V., Chen H.K.J., So S.Y.C., Wong C.Y.S., Chau P.H., Wong M.W.L., Ching H.C.R., Ng L.M.M., Lee W.M., Hung F.N.I., Ho P.L. and Yuen K.Y., A novel risk factor associated with colonization by Carbapenemase-Producing Enterobacteriaceae: Use of Proton Pump Inhibitors in addition to Antimicrobial Treatment, Infection Control & Hospital Epidemiology. 2016, 37: 1418-1425.

Researcher : Chiu TH

List of Research Outputs

Teng L.L., Tang Y., Chiu T.H., Ngan A.H., Ngai C., Wong S.S.Y., Lau S.K.P. and Woo P.C.Y., The groEL gene is a promising target for species-level identification of Tsukamurella, Journal of Clinical Microbiology. American Society for Microbiology, 2017, 55: 649-653.

Woo P.C.Y., Lau S.K.P., Teng L.L., Cao K.Y., Wernery U., Schountz T., Chiu T.H., Tsang K.L., Wong P.C., Wong Y.M. and Yuen K.Y., New Hepatitis E Virus Genotype in Bactrian Camels, Xinjiang, China, 2013, Emerging Infectious Diseases. 2016, 22: 2219-2221.

Researcher : Chong TK

List of Research Outputs

Woo P.C.Y., Lau S.K.P., Lau C.Y., Tung T.K., Chong T.K., Yang F., Zhang H., Lo K.C., Cai J., Au Yeung K.H.R., Ng W.F., Tse H., Wong S.S.Y., Xu S., Lam W.H., Tse M.K., Sze K.H., Kao R.Y.T., Reiner N.E., Hao Q. and Yuen K.Y., Mp1p Is a Virulence Factor in Talaromyces (Penicillium) marneffei, PLOS Neglected Tropical Diseases. 2016, 10: e0004907.

Researcher : Chow KH

List of Research Outputs

Ho P.L., LIU C., Chow K.H., Tse C.W., Lo W.U., Mak S.K. and Lo W.K., Emergence of ileS2 -Carrying, Multidrug-Resistant Plasmids in Staphylococcus lugdunensis , Antimicrobial Agents and Chemotherapy. 2016, 60: 6411-6414.

Ho P.L., Ho L.Y., Yau C.Y., Tong M.K. and Chow K.H., A Novel Selective Medium for Isolation of Bacteroides fragilis from Clinical Specimens, Journal of Clinical Microbiology. 2017, 55: 384-390.

WANG Y., Lo W.U., Lai R.W., Tsw C.W., Lee R.A., Luk W.K., Cheng C.C.V., Que T.L., Chow K.H. and Ho P.L., IncN ST7 epidemic plasmid carrying bla IMP-4 in Enterobacteriaceae isolates with epidemiological links to multiple geographical areas in China , Journal of Antimicrobial Chemotherapy. 2017, 72: 99-103.

WANG Y., Lo W.U., Yau C.Y., Chow K.H. and Ho P.L., Impact of intraobserver and interobserver variation on performance of the CLSI Carba NP assay for carbapenemase detection in Enterobacteriaceae, Journal of Global Antimicrobial Resistance. 2017, 9: 19-20.

Researcher : Chow WN

List of Research Outputs

Lau S.K.P., Lo C.S., Lam C.S., Chow W.N., Ngan A.H., Wu A.K., Tsang D.N., Tse C.W., Que T.L., Tang B.S. and Woo P.C.Y., In Vitro Activity of Posaconazole against Talaromyces marneffei by Broth Microdilution and Etest Methods and Comparison to Itraconazole, Voriconazole, and Anidulafungin, Antimicrobial Agents and Chemotherapy. 2017, 61: e01480-16.

Woo P.C.Y., Lau S.K.P., Tsoi H.W., Patteril N.G., Yeung C., Joseph S., Wong Y.M., Muhammed R., Chow W.N., Wernery U. and Yuen K.Y., Two novel dromedary camel bocaparvoviruses from dromedaries in the Middle East with unique genomic features, The Journal of General Virology. 2017, 98: 1349-1359.

Woo P.C.Y., Lau S.K.P., Tsang C.C., Lau C.Y., Wong P.C., Chow W.N., Fong J.Y.H. and Yuen K.Y., Coronavirus HKU15 in respiratory tract of pigs and first discovery of coronavirus quasispecies in 5′-untranslated region, Emerging Microbes & Infections. 2017, 6: e53.

Researcher : Chu H

Project Title:	Exploring the potential involvement of human macrophage and dendritic cells in the pathogenesis Zika virus
Investigator(s):	Chu H, Zhou J
Department:	Microbiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016
Completion Date:	06/2017

Project Title:	American Society for Virology 36th Annual Meeting; Antibody-Dependent Cell-Mediated Cytotoxicity Epitopes on the Hemagglutinin Head-region of Pandemic H1N1 Influenza Virus Play Detrimental Roles in H1N1-Infected Mice
Investigator(s):	Chu H
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2017
Completion Date:	06/2017

List of Research Outputs

Chan C.M., Chu H., Wang Y., Wong H.Y.B., Zhao X., Zhou J., Yang D., Leung A.S.P., Chan J.F.W., Yeung M.L., Yan J., Lu G., Gao G.F. and Yuen K.Y., Carcinoembryonic Antigen-related Cell Adhesion Molecule 5 (CEACAM5) Is an Important Surface Attachment Factor Facilitating the Entry of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV), Journal of Virology. 2016, JVI.01133-16.

Chan C.M., Chu H., Zhang J., Leung L.H., Sze K.H., Kao R.Y.T., Chik K.K.H., To K.K.W., Chan J.F.W., Chen H., Jin D., Liu L. and Yuen K.Y., Hemagglutinin of influenza A virus binds specifically to cell surface nucleolin and plays a role in virus internalization, Virology. 2016, 494: 78-88.

HU M., Chu H., Zhang K., SINGH K., Li C., Yuan S., Chow B.K.C., Song W., Zhou J. and Zheng B., Amino acid substitutions V63I or A37S/I61T/V63I/V100A in the PA N-terminal domain increase the virulence of H7N7 influenza A virus, Scientific Reports. ENGLAND, Nature Publishing Group, 2016, 6: 37800.

Hu M., Yuan S., Ye Z., SINGH K., Li C., SHUAI H., Ng F., Chow B.K.C., Chu H. and Zheng B., PA N substitutions A37S, A37S/I61T and A37S/V63I attenuate the replication of H7N7 influenza A virus by impairing the polymerase and endonuclease activities, Journal of General Virology. 2017, 98: 364-373.

Lee C.Y., To K.K.W., Zhu H., Chu H., Mak W.N., Zhang J. and Yuen K.Y., Avian influenza virus A H7N9 infects multiple mononuclear cell types in peripheral blood and induces dysregulated cytokine responses and apoptosis in infected monocytes, Journal of General Virology. 2017, 98: 922-934.

Ye Z., Yuan S., Poon K.M., Wen L.R., Yang D., Sun Z., Li C., Hu M., Shuai H., Zhou J., Zhang M., Zheng B., Chu H. and Yuen K.Y., Antibody-Dependent Cell-Mediated Cytotoxicity Epitopes on the Hemagglutinin Head Region of Pandemic H1N1 Influenza Virus Play Detrimental Roles in H1N1-Infected Mice, Frontiers in Immunology. Frontiers, 2017, 8: 317.

Yuan S., Chu H., Zhang K., Ye J., SINGH K., Kao R.Y.T., Chow B.K.C., Zhou J. and Zheng B., A novel small-molecule compound disrupts influenza A virus PB2 cap-binding and inhibits viral replication, Journal of Antimicrobial Chemotherapy. 2016, 71: 2489-2497.

Yuan S., Chu H., Ye J., SINGH K., Ye Z., Zhao H., Kao R.Y.T., Chow B.K.C., Zhou J. and Zheng B., Identification of a novel small-molecule compound targeting the influenza A virus polymerase PB1-PB2 interface, Antiviral Research. NETHERLANDS, ELSEVIER SCIENCE BV, 2016, 137: 58-66.

Yuan S., Chu H., Ye J., Hu M., SINGH K., Chow B.K.C., Zhou J. and Zheng B., Peptide-Mediated Interference of PB2-eIF4G1 Interaction Inhibits Influenza A Viruses’ Replication in Vitro and in Vivo, ACS Infectious Diseases. 2016, 2: 471-477.

Zhao H., Chu H., Zhao X., SHUAI H., Wong H.Y.B., Wen L.R., Yuan S., Zheng B., Zhou J. and Yuen K.Y., Novel residues in the PA protein of avian influenza H7N7 virus affect virulence in mammalian hosts, Virology. 2016, 498: 1-8.

Researcher : Dai J

List of Research Outputs

CHEUNG N.N., Lai K.K., Dai J., Kok K.H., Chen H., Chan K.H., Yuen K.Y. and Kao R.Y.T., Broad-spectrum inhibition of common respiratory RNA viruses by a pyrimidine synthesis inhibitor with involvement of the host antiviral response. , Journal of General Virology. 2017.

PANG B., Cheung N.N., ZHANG W., Dai J., Kao R.Y.T., Zhang H. and Hao Q., Structural Characterization of H1N1 Nucleoprotein-Nucleozin Binding Sites, Scientific Reports. 2016, 6: 29684.

Researcher : Fan YY

List of Research Outputs

Lau S.K.P., Ahmed S.S., Yeung C., Li K.S.M., Fan Y.Y., Cheng T.Y., Cai J., Wang M., Zheng B., Wong S.S.Y., Woo P.C.Y. and Yuen K.Y., Identification and interspecies transmission of a novel bocaparvovirus among different bat species in China, The Journal of General Virology. 2016, 97: 3345-3358.

Lau S.K.P., Woo P.C.Y., Li K.S.M., Zhang H.J., Fan Y.Y., Zhang J., Chan B.C., Lam S.F., Yip C.Y., Yuen M.C., Chan K.H., Chen Z. and Yuen K.Y., Identification of Novel Rosavirus Species That Infects Diverse Rodent Species and Causes Multisystemic Dissemination in Mouse Model, PLoS Pathogen. 2016, 12: e1005911.

Woo P.C.Y., Wong Y.M., Wong B.H., Lam S.F., Fan Y.Y., Lau S.K.P. and Yuen K.Y., Comparative genome and evolutionary analysis of naturally occurring Beilong virus in brown and black rats., Infection, Genetics and Evolution. 2016, 45: 311-319.

Researcher : Gao P

Project Title:	2016 world life science conference; Construction of a Multiplex Promoter Reporter Platform to Monitor Staphylococcus aureus Virulence Gene Expression
Investigator(s):	Gao P
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2016
Completion Date:	11/2016

List of Research Outputs

Gao P., Wang Y., Villanueva I., Ho P.L., Davies J. and Kao R.Y.T., Construction of a Multiplex Promoter Reporter Platform to Monitor Staphylococcus aureus Virulence Gene Expression and the Identification of Usnic Acid as a Potent Suppressor of psm Gene Expression, In: Dongsheng Zhou, Frontiers in Microbiology. 2016, 7: 1-14.

Gao P., Wang Y., Villanueva I.V.Á.N., Ho P.L., Davies J.U.L.I.A.N. and Kao R.Y.T., Multiplex Promoter Reporter Platform to Monitor Staphylococcus aureus Virulence Gene Expression , 2016 world life science conference. 2016.

Kao R.Y.T. and Gao P., IDENTIFICATION OF ANTI-VIRULENCE COMPOUNDS FOR COMBATING STAPHYLOCOCCUS AUREUS INFECTIONS BY HIGH-THROUGHPUT SCREENING (HTS), International Conference on Prevention & Infection Control. 2017.

Kao R.Y.T. and Gao P., Innovation Academy Award, International Consortium on Prevention and Infection Control (ICPIC). 2017.

Researcher : Guan Y

Project Title:	Vaccines for the control of H5N1 and other avian influenza viruses
Investigator(s):	Guan Y
Department:	Microbiology
Source(s) of Funding:	The University of Hong Kong Foundation Seed Grant
Start Date:	04/2002

Project Title:	Searching for the precursor of SARS-Cov in Southern China
Investigator(s):	Guan Y
Department:	Microbiology
Source(s) of Funding:	VCO SARS Research Fund
Start Date:	07/2003

Project Title:	Special Research Achievement Award 2003-2004
Investigator(s):	Guan Y
Department:	School of Public Health
Source(s) of Funding:	Special Research Achievement Award
Start Date:	11/2004

Project Title:	Partner State Key Laboratory of Emerging Infectious Diseases
Investigator(s):	Guan Y
Department:	Microbiology
Source(s) of Funding:	Matching Fund for State Key Laboratory (SKL)
Start Date:	02/2009

Project Title:	Research Output Prize (Li Ka Shing Faculty of Medicine)
Investigator(s):	Guan Y
Department:	School of Public Health
Source(s) of Funding:	Research Output Prize (in Faculty)
Start Date:	01/2013

Project Title:	Outstanding Researcher Award 2013-14
Investigator(s):	Guan Y
Department:	School of Public Health
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	12/2014

Researcher : HU M

List of Research Outputs

HU M., Chu H., Zhang K., SINGH K., Li C., Yuan S., Chow B.K.C., Song W., Zhou J. and Zheng B., Amino acid substitutions V63I or A37S/I61T/V63I/V100A in the PA N-terminal domain increase the virulence of H7N7 influenza A virus, Scientific Reports. ENGLAND, Nature Publishing Group, 2016, 6: 37800.

Hu M., Yuan S., Ye Z., SINGH K., Li C., SHUAI H., Ng F., Chow B.K.C., Chu H. and Zheng B., PA N substitutions A37S, A37S/I61T and A37S/V63I attenuate the replication of H7N7 influenza A virus by impairing the polymerase and endonuclease activities, Journal of General Virology. 2017, 98: 364-373.

Ye Z., Yuan S., Poon K.M., Wen L.R., Yang D., Sun Z., Li C., Hu M., Shuai H., Zhou J., Zhang M., Zheng B., Chu H. and Yuen K.Y., Antibody-Dependent Cell-Mediated Cytotoxicity Epitopes on the Hemagglutinin Head Region of Pandemic H1N1 Influenza Virus Play Detrimental Roles in H1N1-Infected Mice, Frontiers in Immunology. Frontiers, 2017, 8: 317.

Yuan S., Chu H., Ye J., Hu M., SINGH K., Chow B.K.C., Zhou J. and Zheng B., Peptide-Mediated Interference of PB2-eIF4G1 Interaction Inhibits Influenza A Viruses’ Replication in Vitro and in Vivo, ACS Infectious Diseases. 2016, 2: 471-477.

Researcher : HUANG X

List of Research Outputs

HUANG X., ZHENG M., Wang P., Mok B.W.Y., LIU S., Lau S.Y., CHEN P., Liu Y., LIU H., CHEN Y., Song W., Yuen K.Y. and Chen H., An NS-segment exonic splicing enhancer regulates influenza A virus replication in mammalian cells, Nature Communications. 2017, 8: 14751.

WU X., Liu L., Cheung K.W., Wang H., Lu X., Cheung K.L.A., LIU W., Huang X., Li Y., Chen Z., CHEN S.M.Y., Zhang T., Wu H. and Chen Z., Brain Invasion by CD4+ T Cells Infected with a Transmitted/Founder HIV-1BJZS7 During Acute Stage in Humanized Mice, Journal of Neuroimmune Pharmacology. 2016, 11: 572-583.

Zheng M., Wang P., Lau S.Y., HUANG X., Mok B.W.Y., LIU S., LIU H., Liu Y. and Chen H., Characterization of mutations associated with cold adapted properties in DelNS1 influenza viruses; potential for new live attenuated influenza vaccine development , Options IX for The Control of Influenza, Chicago, USA, 24-28 Aug, 2016.

Researcher : Ho PL

Project Title:	A phenotypic and genotypic analysis of vancomycin tolerance in Streptococcus pnemoniae
Investigator(s):	Ho PL, Yuen KY, Que TL
Department:	Microbiology
Source(s) of Funding:	Low Budget High Impact Programme
Start Date:	11/2000

Project Title:	Molecular epidemiology of fluoroquinolone-resistant streptococcus pneumoniae in Hong kong and Canada
Investigator(s):	Ho PL
Department:	Microbiology
Source(s) of Funding:	Low Budget High Impact Programme
Start Date:	11/2001

Project Title:	Risk factors for SARS in health care workers following incubation of SARS patients
Investigator(s):	Ho PL, Hung CT
Department:	Microbiology
Source(s) of Funding:	VCO SARS Research Fund
Start Date:	07/2003

Project Title:	Fluoroquinolone susceptibility clinical breakpoints and fluoroquinolone-resistant determining mutations among clinical strains of streptococcus pneumoniae
Investigator(s):	Ho PL, Wong SSY
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Project Title:	Evaluation of molecular tests for the rapid detection of rifampicin and isoniazid resistance in Mycobacterium tuberculosis and their impact on patient management
Investigator(s):	Ho PL, Yam WC, Leung CC, Yew WW, Mok YWT, Chan KS, Tam CM
Department:	Microbiology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	04/2006

Project Title:	Syndromic Surveillance and Modeling for Infectious Diseases
Investigator(s):	Ho PL, Wu JTK
Department:	Microbiology
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2013

Project Title:	Molecular epidemiology of transferrable multidrug-resistant pump oqxAB in Escherichia coli from human and animal sources
Investigator(s):	Ho PL, Lo WU
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2015

Project Title:	Unveiling the characteristics of emerging Staphylococcus lugdunensis sequence type 3 clone by genomics analysis
Investigator(s):	Ho PL, Sham PC, Lo WU
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2016

Project Title:	Development and validation of a MALDI-TOF based rapid test for detection of emerging carbapenem resistance in Bacteroides fragilis
Investigator(s):	Ho PL, Lo WU
Department:	Microbiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2016

List of Research Outputs

Cheng C.C.V., Chen H.K.J., So S.Y.C., Wong C.Y.S., Chau P.H., Wong M.W.L., Ching H.C.R., Ng L.M.M., Lee W.M., Hung F.N.I., Ho P.L. and Yuen K.Y., A novel risk factor associated with colonization by Carbapenemase-Producing Enterobacteriaceae: Use of Proton Pump Inhibitors in addition to Antimicrobial Treatment, Infection Control & Hospital Epidemiology. 2016, 37: 1418-1425.

Gao P., Wang Y., Villanueva I., Ho P.L., Davies J. and Kao R.Y.T., Construction of a Multiplex Promoter Reporter Platform to Monitor Staphylococcus aureus Virulence Gene Expression and the Identification of Usnic Acid as a Potent Suppressor of psm Gene Expression, In: Dongsheng Zhou, Frontiers in Microbiology. 2016, 7: 1-14.

Gao P., Wang Y., Villanueva I.V.Á.N., Ho P.L., Davies J.U.L.I.A.N. and Kao R.Y.T., Multiplex Promoter Reporter Platform to Monitor Staphylococcus aureus Virulence Gene Expression , 2016 world life science conference. 2016.

Ho P.L., LIU C., Chow K.H., Tse C.W., Lo W.U., Mak S.K. and Lo W.K., Emergence of ileS2 -Carrying, Multidrug-Resistant Plasmids in Staphylococcus lugdunensis , Antimicrobial Agents and Chemotherapy. 2016, 60: 6411-6414.

Ho P.L., Ho L.Y., Yau C.Y., Tong M.K. and Chow K.H., A Novel Selective Medium for Isolation of Bacteroides fragilis from Clinical Specimens, Journal of Clinical Microbiology. 2017, 55: 384-390.

WANG Y., Lo W.U., Lai R.W., Tsw C.W., Lee R.A., Luk W.K., Cheng C.C.V., Que T.L., Chow K.H. and Ho P.L., IncN ST7 epidemic plasmid carrying bla IMP-4 in Enterobacteriaceae isolates with epidemiological links to multiple geographical areas in China , Journal of Antimicrobial Chemotherapy. 2017, 72: 99-103.

WANG Y., Lo W.U., Yau C.Y., Chow K.H. and Ho P.L., Impact of intraobserver and interobserver variation on performance of the CLSI Carba NP assay for carbapenemase detection in Enterobacteriaceae, Journal of Global Antimicrobial Resistance. 2017, 9: 19-20.

Wong S.C.Y., Tse H., Chen H.K.J., Cheng V.C.C., Ho P.L. and Yuen K.Y., Colistin-Resistant Enterobacteriaceae Carrying the mcr-1 Gene among Patients in Hong Kong , Emerging Infectious Diseases. 2016, 22: 1667-1669.

Researcher : Ho TY

List of Research Outputs

Chan J.F.W., Yip C.Y., Ho T.Y., Chan K.H., Hung F.N.I. and Yuen K.Y., Surveillance for Zika virus infection among asymptomatic returning travelers from the Rio Olympic and Paralymic Games, 33rd ASM Clinical Virology Symposium. 2017.

To K.K.W., Lu L., Yip C.Y., Poon W.S.R., Fung A.M.Y., Cheng A., Lui D.H.K., Ho T.Y., Hung F.N.I., Chan K.H. and Yuen K.Y., Additional molecular testing of saliva specimens improves the detection of respiratory viruses, Emerging Microbes & Infections. 2017, 6: e49.

Researcher : Hu M

List of Research Outputs

Researcher : Huang X

List of Research Outputs

Researcher : Huang Y

List of Research Outputs

Cheung K.L.A., Huang Y., Chen M. and Chen Z., Human cytomegalovirus latent infection modulates HIV restriction factors in CD34+ hematopoietic stem cells (WEPEA016), AIDS 2016.

Cheung K.L.A., Huang Y., Kwok H.Y., Chen M. and Chen Z., Latent human cytomegalovirus enhances HIV-1 infection in CD34+ progenitor cells, In: Geoffrey Hill, Blood Advances. Washington, DC, USA, The American Society of Hematology, 2017, 1: 306-318.

TANG Y., Teng L.L., Cheung C.L., Ngan A.H., Huang Y., Wong S.S.Y., Yip E.K., Ng K.H., Que T.L., Lau S.K.P. and Woo P.C.Y., Tsukamurellaserpentis sp. nov., isolated from the oral cavity of Chinese cobras (Naja atra), International Journal of Systematic and Evolutionary Microbiology. 2016, 66: 3329-3336.

Researcher : Hung FNI

Project Title:	Efficacy and safety of a novel intradermal live-attenuated varicella zoster vaccine in hematopoietic stem cell transplantation donors: a randomized double-blind placebo-controlled trial
Investigator(s):	Hung FNI, Lie AKW, Leung AYH, To KKW, Yuen KY
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2013

Project Title:	A double blind randomized controlled trial of intradermal hepatitis B vaccination with topical imiquimod in dialyzed patients with chronic renal failure
Investigator(s):	Hung FNI, Yuen KY, Tang SCW, To KKW, Yap YHD
Department:	Medicine
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2014

Project Title:	Treatment of severe influenza A infection with celecoxib: a double blind randomized controlled trial
Investigator(s):	Hung FNI, To KKW, Chan JFW, Chan KH, Yuen KY
Department:	Medicine
Source(s) of Funding:	Commissioned Studies on Emerging Influenza A Viruses with Epidemic Potential
Start Date:	12/2014

Project Title:	A double-blind randomized controlled trial of 13-valent pneumococcal conjugated vaccine in patients with chronic illness
Investigator(s):	Hung FNI, Chan KH
Department:	Medicine
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2015

List of Research Outputs

Chan J.F.W., Choi G.K.Y., Leung S.S.M., Tee K.M., Tang S.F., Hung F.N.I. and Yuen K.Y., Epidemiological and clinical characteristics of patients with anti-interferon-gamma autoantibodies associated with opportunistic infections in Hong Kong, European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 2017.

Chan J.F.W., Choi G.K.Y., Leung S.S.M., Tee K.M., Tang S.F., Hung F.N.I. and Yuen K.Y., Epidemiology, Seroprevalence, and Clinical Manifestations of Immunodeficiency due to Autoantibody Against Interferon Gamma in Hong Kong, Health Research Symposium 2017 (Health and Medical Research Fund). 2017.

Chan J.F.W., Yip C.Y., Ho T.Y., Chan K.H., Hung F.N.I. and Yuen K.Y., Surveillance for Zika virus infection among asymptomatic returning travelers from the Rio Olympic and Paralymic Games, 33rd ASM Clinical Virology Symposium. 2017.

Chan P.H.M., Hai S.H.J.J., Huang D., Ho M.H., Chan E.W., Cheung B.M.Y., Wong I.C.K., Tse H.F., Hung F.N.I. and Siu D.C.W., Burden of upper gastrointestinal symptoms in patients prescribed Dabigatran for stroke prevention., Sage Open Medicine . 2016, 4:2050312116662414.

Cheng C.C.V., Chen H.K.J., So S.Y.C., Wong C.Y.S., Chau P.H., Wong M.W.L., Ching H.C.R., Ng L.M.M., Lee W.M., Hung F.N.I., Ho P.L. and Yuen K.Y., A novel risk factor associated with colonization by Carbapenemase-Producing Enterobacteriaceae: Use of Proton Pump Inhibitors in addition to Antimicrobial Treatment, Infection Control & Hospital Epidemiology. 2016, 37: 1418-1425.

Yip C.Y., Tee K.M., ZHU Z., TSANG O.L., CHIK K.K.H., TSANG G.W.T., Chan C.S., Poon K.M., Sridhar S., Yin F., Hung F.N.I., Chau S.K.Y., Zhang J., Chan K.H., Yuen K.Y. and Chan J.F.W., Improved detection of Zika virus RNA in human and animal specimens by a novel, highly sensitive and specific real-time RT-PCR assay targeting the 5'-untranslated region of Zika virus, 33rd ASM Clinical Virology Symposium. 2017.

Researcher : Hung LL

List of Research Outputs

Chan G.C.W., Mok M.M.Y., Hung L.L., Chan J.F.W., Kwan L.P.Y., Ma M.K.M., Yap Y.H.D. and Tang S.C.W., Mycobacterium chlorophenolicum: An uncommon cause of peritonitis in a peritoneal dialysis patient., Nephrology (Carlton). 2017, 22(6): 498-499.

Researcher : Im SWK

Project Title:	Investigation of community exposure to a novel coronavirus associated with SARS and herd immunity developed among healthy blood donors
Investigator(s):	Im SWK, Yam WC
Department:	Microbiology
Source(s) of Funding:	VCO SARS Research Fund
Start Date:	07/2003

Researcher : Kao RYT

Project Title:	Development of anti-virulence strategy by targeting the SaeS signaling system of Staphylococcus aureus
Investigator(s):	Kao RYT, Gao P
Department:	Microbiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2017

List of Research Outputs

CHEUNG N.N., Lai K.K., Dai J., Kok K.H., Chen H., Chan K.H., Yuen K.Y. and Kao R.Y.T., Broad-spectrum inhibition of common respiratory RNA viruses by a pyrimidine synthesis inhibitor with involvement of the host antiviral response. , Journal of General Virology. 2017.

Chan C.M., Chu H., Zhang J., Leung L.H., Sze K.H., Kao R.Y.T., Chik K.K.H., To K.K.W., Chan J.F.W., Chen H., Jin D., Liu L. and Yuen K.Y., Hemagglutinin of influenza A virus binds specifically to cell surface nucleolin and plays a role in virus internalization, Virology. 2016, 494: 78-88.

Chan J.F.W., CHIK K.K.H., Yuan S., Kao R.Y.T. and Yuen K.Y., Identification of bromocriptine as a Zika virus NS2B-NS3 protease inhibitor, American Society for Virology (ASV) 36th Annual Meeting. 2017.

Chan J.F.W., CHIK K.K.H., Yuan S., Yip C.Y., ZHU Z., Tee K.M., TSANG O.L., Chan C.S., Poon K.M., Lu G., Zhang J., Lai K.K., Chan K.H., Kao R.Y.T. and Yuen K.Y., Novel antiviral activity and mechanism of bromocriptine as a Zika virus NS2B-NS3 protease inhibitor, Antiviral Research. 2017, 141: 29-37.

Gao P., Wang Y., Villanueva I., Ho P.L., Davies J. and Kao R.Y.T., Construction of a Multiplex Promoter Reporter Platform to Monitor Staphylococcus aureus Virulence Gene Expression and the Identification of Usnic Acid as a Potent Suppressor of psm Gene Expression, In: Dongsheng Zhou, Frontiers in Microbiology. 2016, 7: 1-14.

Gao P., Wang Y., Villanueva I.V.Á.N., Ho P.L., Davies J.U.L.I.A.N. and Kao R.Y.T., Multiplex Promoter Reporter Platform to Monitor Staphylococcus aureus Virulence Gene Expression , 2016 world life science conference. 2016.

Kao R.Y.T. and Gao P., IDENTIFICATION OF ANTI-VIRULENCE COMPOUNDS FOR COMBATING STAPHYLOCOCCUS AUREUS INFECTIONS BY HIGH-THROUGHPUT SCREENING (HTS), International Conference on Prevention & Infection Control. 2017.

Kao R.Y.T. and Gao P., Innovation Academy Award, International Consortium on Prevention and Infection Control (ICPIC). 2017.

Li H., Yang X., WANG R., KOOHIMOGHADAM M., Woo P.C.Y., Kao R.Y.T. and Sun H., UreG as a target for the development of urease inhibitor: a new strategy for design of antimicrobial agents, 8th Asian Biological Inorganic Chemistry Conference. 2016.

PANG B., Cheung N.N., ZHANG W., Dai J., Kao R.Y.T., Zhang H. and Hao Q., Structural Characterization of H1N1 Nucleoprotein-Nucleozin Binding Sites, Scientific Reports. 2016, 6: 29684.

Sze K.H., Lam W.H., Zhang H., Ke Y., Tse M.K., Woo P.C.Y., Lau S.K.P., Lau C.Y., Cai J., Tung E.T., Lo R.K., Xu S., Kao R.Y.T., Hao Q. and Yuen K.Y., Talaromyces marneffei Mp1p Is a Virulence Factor that Binds and Sequesters a Key Proinflammatory Lipid to Dampen Host Innate Immune Response, Cell Chemical Biology. 2017, 24: 182-194.

Woo P.C.Y., Lau S.K.P., Lau C.Y., Tung T.K., Chong T.K., Yang F., Zhang H., Lo K.C., Cai J., Au Yeung K.H.R., Ng W.F., Tse H., Wong S.S.Y., Xu S., Lam W.H., Tse M.K., Sze K.H., Kao R.Y.T., Reiner N.E., Hao Q. and Yuen K.Y., Mp1p Is a Virulence Factor in Talaromyces (Penicillium) marneffei, PLOS Neglected Tropical Diseases. 2016, 10: e0004907.

Yuan S., Chu H., Zhang K., Ye J., SINGH K., Kao R.Y.T., Chow B.K.C., Zhou J. and Zheng B., A novel small-molecule compound disrupts influenza A virus PB2 cap-binding and inhibits viral replication, Journal of Antimicrobial Chemotherapy. 2016, 71: 2489-2497.

Yuan S., Chu H., Ye J., SINGH K., Ye Z., Zhao H., Kao R.Y.T., Chow B.K.C., Zhou J. and Zheng B., Identification of a novel small-molecule compound targeting the influenza A virus polymerase PB1-PB2 interface, Antiviral Research. NETHERLANDS, ELSEVIER SCIENCE BV, 2016, 137: 58-66.

ZHANG B., Cai J., Yu B., HUA Y., Lau C.Y., Kao R.Y.T., Sze K.H., Yuen K.Y. and Huang J., A DNA vaccine targeting TcdA and TcdB induces protective immunity against Clostridium difficile, BMC Infectious Diseases. 2016, 16.

Researcher : Ke Y

List of Research Outputs

Sze K.H., Lam W.H., Zhang H., Ke Y., Tse M.K., Woo P.C.Y., Lau S.K.P., Lau C.Y., Cai J., Tung E.T., Lo R.K., Xu S., Kao R.Y.T., Hao Q. and Yuen K.Y., Talaromyces marneffei Mp1p Is a Virulence Factor that Binds and Sequesters a Key Proinflammatory Lipid to Dampen Host Innate Immune Response, Cell Chemical Biology. 2017, 24: 182-194.

Researcher : Kok KH

Project Title:	Identification of a novel splice isoform of TRBP and characterization of its role in microRNA biogenesis
Investigator(s):	Kok KH, Wong CM
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2012

Project Title:	Mechanistic study of the roles of PACT in MDA5-mediated innate antiviral immunity
Investigator(s):	Kok KH, Chan CP
Department:	School of Biomedical Sciences
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2013

Project Title:	Role of PACT in host antiviral defence against influenza A virus
Investigator(s):	Kok KH
Department:	Biochemistry
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	01/2013
Completion Date:	10/2016

Project Title:	Suppression of PACT-dependent antiviral response by measles virus V protein
Investigator(s):	Kok KH
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2015

Project Title:	Functional role of PACT in limiting replication of influenza A virus
Investigator(s):	Kok KH
Department:	Microbiology
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	01/2016

Project Title:	Innate immune sensing of rotavirus
Investigator(s):	Kok KH
Department:	Microbiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2016

Project Title:	A novel approach for the identification of N6-methyladenosine (m6A) RNA modification in human and viral mRNA
Investigator(s):	Kok KH
Department:	Microbiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2017

Project Title:	The role of ARRDC3 in the innate immune response to influenza A virus infection
Investigator(s):	Kok KH, Chen H
Department:	Microbiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2017

Project Title:	The 36th Annual Meeting of American Society for Virology; Inhibition of primary interferon production by Measles virus V protein
Investigator(s):	Kok KH
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2017
Completion Date:	06/2017

List of Research Outputs

CHAUDHARY V., Zhang S., Yuen K.S., Li D., Kok K.H., Liang M. and Jin D., Differential modulation of type I and type II interferon signaling by severe fever-with-thrombocytopenia syndrome virus NSs protein., 2016 World Life Science Conference. Beijing, China, 2016.

CHAUDHARY V., ZHANG S., LI D., LIANG M., Kok K.H. and Jin D., Dual regulatory effects of SFTS virus NSs protein on interferon signaling, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

CHAUDHARY V., Yuen K.S., Chan J.F.W., Chan C.P., Kok K.H., Chan C.P., Yuen K.Y. and Jin D., Selective activation of interferon-γ signaling by Zika virus NS5 protein (invited speaker)., 2016 World Life Science Conference.. Beijing, China, 2016.

CHAUDHARY V., Yuen K.S., Chan J.F.W., Chan C.P., Wang F., Kok K.H., Chan C.P., Yuen K.Y. and Jin D., Zika virus NS5 protein differentially modulates type I and type II interferon signaling., Cross Street Immunology Conference, National Taiwan University, Taipei, March 18-19, 2017.. 2017.

CHEUNG N.N., Lai K.K., Dai J., Kok K.H., Chen H., Chan K.H., Yuen K.Y. and Kao R.Y.T., Broad-spectrum inhibition of common respiratory RNA viruses by a pyrimidine synthesis inhibitor with involvement of the host antiviral response. , Journal of General Virology. 2017.

Chan C.P., Yuen C.K.J., Fung S.Y., CHEUNG P.H.H., Chen H., Kok K.H. and Jin D., Antiviral activity of double-stranded RNA-binding protein PACT against influenza A virus mediated through suppression of viral RNA polymerase, FOCIS 2017.

Chan J.F.W., Zhang J., Chan C.S., Yip C.Y., Mak W.N., Zhu H., Poon K.M., Tee K.M., Zhu Z., Cai J., Tsang O.L., Chik K.K.H., Yin F., Chan K.H., Kok K.H., Jin D., Au Yeung K.H.R. and Yuen K.Y., Characterization of a novel mouse model for Zika virus infection using dexamethasone-immunosuppressed mice, First International Conference on Zika Virus. 2017.

Chan J.F.W., Yip C.Y., Tsang O.L., Tee K.M., Cai J., Chik K.K.H., Zhu Z., Chan C.S., CHOI K.Y., Sridhar S., Zhang J., Lu G., Chiu K., Lo A.C.Y., Tsao G.S.W., Kok K.H., Jin D., Chan K.H. and Yuen K.Y., Differential cell line susceptibility to the emerging Zika virus: implications for disease pathogenesis, non-vector-borne human transmission and animal reservoirs, Emerging Microbes & Infections. 2016, 5: e93.

Chan J.F.W., Zhang J., Chan C.S., Yip C.Y., Mak W.N., Zhu H., Poon K.M., Tee K.M., Zhu Z., Cai J., Tsang O.L., Chik K.K.H., Yin F., Chan K.H., Kok K.H., Jin D., Au Yeung K.H.R. and Yuen K.Y., Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons, EBioMedicine. 2016, 14: 112-122.

Chaudhary V., Yuen K.S., Chan J.F.W., Chan C.P., Wang F., Cai J., Zhang S., Liang M., Kok K.H., Chan C.P., Yuen K.Y. and Jin D., Selective activation of type II interferon signaling by Zika virus NS5 protein, J Virol. 2017, 91(14): e00163-17.

FUNG S.Y., YUEN C.K., ZHU W., LIANG G., Kok K.H., Chan C.P. and Jin D., Activation of nucleic acid sensing cGAS-STING pathway by Sindbis Virus, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

FUNG S.Y., Chan C.P., YUEN C.K., Kok K.H., Chan C.P. and Jin D., Human T-cell leukemia virus type 1 Tax and HBZ proteins differentially suppress RNA- and DNA-induced innate antiviral response., 18th International Conference on Human Retrovirology: HTLV-1 and Related Viruses, Tokyo, Japan, March 7-10, 2017.. 2017.

Yuen K.S., Chan C.P., Kok K.H. and Jin D., Mutagenesis and genome engineering of Epstein-Barr virus in cultured human cells by CRISPR/Cas9., Methods in Molecular Biology. 2016, 1498: 23-31.

Researcher : Kwok HY

List of Research Outputs

Cheung K.L.A., Huang Y., Kwok H.Y., Chen M. and Chen Z., Latent human cytomegalovirus enhances HIV-1 infection in CD34+ progenitor cells, In: Geoffrey Hill, Blood Advances. Washington, DC, USA, The American Society of Hematology, 2017, 1: 306-318.

Researcher : LIU C

List of Research Outputs

Ho P.L., LIU C., Chow K.H., Tse C.W., Lo W.U., Mak S.K. and Lo W.K., Emergence of ileS2 -Carrying, Multidrug-Resistant Plasmids in Staphylococcus lugdunensis , Antimicrobial Agents and Chemotherapy. 2016, 60: 6411-6414.

Researcher : LIU H

List of Research Outputs

HUANG X., ZHENG M., Wang P., Mok B.W.Y., LIU S., Lau S.Y., CHEN P., Liu Y., LIU H., CHEN Y., Song W., Yuen K.Y. and Chen H., An NS-segment exonic splicing enhancer regulates influenza A virus replication in mammalian cells, Nature Communications. 2017, 8: 14751.

Zheng M., Wang P., Lau S.Y., HUANG X., Mok B.W.Y., LIU S., LIU H., Liu Y. and Chen H., Characterization of mutations associated with cold adapted properties in DelNS1 influenza viruses; potential for new live attenuated influenza vaccine development , Options IX for The Control of Influenza, Chicago, USA, 24-28 Aug, 2016.

Researcher : LIU S

List of Research Outputs

HUANG X., ZHENG M., Wang P., Mok B.W.Y., LIU S., Lau S.Y., CHEN P., Liu Y., LIU H., CHEN Y., Song W., Yuen K.Y. and Chen H., An NS-segment exonic splicing enhancer regulates influenza A virus replication in mammalian cells, Nature Communications. 2017, 8: 14751.

Zheng M., Wang P., Lau S.Y., HUANG X., Mok B.W.Y., LIU S., LIU H., Liu Y. and Chen H., Characterization of mutations associated with cold adapted properties in DelNS1 influenza viruses; potential for new live attenuated influenza vaccine development , Options IX for The Control of Influenza, Chicago, USA, 24-28 Aug, 2016.

Researcher : LIU W

List of Research Outputs

WU X., Liu L., Cheung K.W., Wang H., Lu X., Cheung K.L.A., LIU W., Huang X., Li Y., Chen Z., CHEN S.M.Y., Zhang T., Wu H. and Chen Z., Brain Invasion by CD4+ T Cells Infected with a Transmitted/Founder HIV-1BJZS7 During Acute Stage in Humanized Mice, Journal of Neuroimmune Pharmacology. 2016, 11: 572-583.

Researcher : Lai KK

List of Research Outputs

CHEUNG N.N., Lai K.K., Dai J., Kok K.H., Chen H., Chan K.H., Yuen K.Y. and Kao R.Y.T., Broad-spectrum inhibition of common respiratory RNA viruses by a pyrimidine synthesis inhibitor with involvement of the host antiviral response. , Journal of General Virology. 2017.

Chan J.F.W., CHIK K.K.H., Yuan S., Yip C.Y., ZHU Z., Tee K.M., TSANG O.L., Chan C.S., Poon K.M., Lu G., Zhang J., Lai K.K., Chan K.H., Kao R.Y.T. and Yuen K.Y., Novel antiviral activity and mechanism of bromocriptine as a Zika virus NS2B-NS3 protease inhibitor, Antiviral Research. 2017, 141: 29-37.

Researcher : Lam SF

List of Research Outputs

Lau S.K.P., Yeung C., Li K.S.M., Lam S.F., Cai J., Yuen M.C., Wang M., Zheng B., Woo P.C.Y. and Yuen K.Y., Identification and genomic characterization of a novel rat bocavirus from brown rats in China, Infection, Genetics and Evolution. 2017, 47: 68-76.

Lau S.K.P., Woo P.C.Y., Li K.S.M., Zhang H.J., Fan Y.Y., Zhang J., Chan B.C., Lam S.F., Yip C.Y., Yuen M.C., Chan K.H., Chen Z. and Yuen K.Y., Identification of Novel Rosavirus Species That Infects Diverse Rodent Species and Causes Multisystemic Dissemination in Mouse Model, PLoS Pathogen. 2016, 12: e1005911.

To K.K.W., Chan W.M., Li K.S.M., Lam S.F., Chen Z., Tse H., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., High prevalence of four novel astrovirus genotype species identified from rodents in China, Journal of General Virology. 2017, 98: 1004-1015.

Woo P.C.Y., Wong Y.M., Wong B.H., Lam S.F., Fan Y.Y., Lau S.K.P. and Yuen K.Y., Comparative genome and evolutionary analysis of naturally occurring Beilong virus in brown and black rats., Infection, Genetics and Evolution. 2016, 45: 311-319.

Woo P.C.Y., Teng L.L., BAI R., Wong Y.P., Martelli P., Hui S.W., Tsang K.L., Lau C.Y., Ahmed S.S., Yip C.Y., CHOI K.Y., Li K.S.M., Lam S.F., Lau S.K.P. and Yuen K.Y., High Diversity of Genogroup I Picobirnaviruses in Mammals, Frontier in microbiology. 2016, 7: 1886.

Researcher : Lau CY

List of Research Outputs

Sze K.H., Lam W.H., Zhang H., Ke Y., Tse M.K., Woo P.C.Y., Lau S.K.P., Lau C.Y., Cai J., Tung E.T., Lo R.K., Xu S., Kao R.Y.T., Hao Q. and Yuen K.Y., Talaromyces marneffei Mp1p Is a Virulence Factor that Binds and Sequesters a Key Proinflammatory Lipid to Dampen Host Innate Immune Response, Cell Chemical Biology. 2017, 24: 182-194.

Woo P.C.Y., Teng L.L., BAI R., Wong Y.P., Martelli P., Hui S.W., Tsang K.L., Lau C.Y., Ahmed S.S., Yip C.Y., CHOI K.Y., Li K.S.M., Lam S.F., Lau S.K.P. and Yuen K.Y., High Diversity of Genogroup I Picobirnaviruses in Mammals, Frontier in microbiology. 2016, 7: 1886.

Woo P.C.Y., Lau S.K.P., Lau C.Y., Tung T.K., Chong T.K., Yang F., Zhang H., Lo K.C., Cai J., Au Yeung K.H.R., Ng W.F., Tse H., Wong S.S.Y., Xu S., Lam W.H., Tse M.K., Sze K.H., Kao R.Y.T., Reiner N.E., Hao Q. and Yuen K.Y., Mp1p Is a Virulence Factor in Talaromyces (Penicillium) marneffei, PLOS Neglected Tropical Diseases. 2016, 10: e0004907.

Woo P.C.Y., Lau S.K.P., Tsang C.C., Lau C.Y., Wong P.C., Chow W.N., Fong J.Y.H. and Yuen K.Y., Coronavirus HKU15 in respiratory tract of pigs and first discovery of coronavirus quasispecies in 5′-untranslated region, Emerging Microbes & Infections. 2017, 6: e53.

ZHANG B., Cai J., Yu B., HUA Y., Lau C.Y., Kao R.Y.T., Sze K.H., Yuen K.Y. and Huang J., A DNA vaccine targeting TcdA and TcdB induces protective immunity against Clostridium difficile, BMC Infectious Diseases. 2016, 16.

Researcher : Lau S.K.P.

Project Title:	Molecular diversity and evolution of bat group C betacoronaviruses: implications on the origin of the novel human group C betacoronavirus
Investigator(s):	Lau SKP, Woo PCY, Zheng B
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	09/2013
Completion Date:	02/2017

Project Title:	Matrix-assisted laser desorption ionization time-of-flight mass spectrometry for rapid identification of Penicillium marneffei
Investigator(s):	Lau SKP, Woo PCY
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2015

Project Title:	Study of the genome evolution, interspecies transmission and pathogenicity of a novel animal picornavirus
Investigator(s):	Lau SKP, Woo PCY, Yuen KY
Department:	Microbiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2015

Project Title:	Genomic characterization of a novel rat bocaparvovirus from Norway rats in China
Investigator(s):	Lau SKP, Woo PCY
Department:	Microbiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2016

Project Title:	Characterization of mycoviruses in the thermally dimorphic fungus Talaromyces marneffei
Investigator(s):	Lau SKP, Woo PCY
Department:	Microbiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2017

Project Title:	2nd International Symposium on Infectious Diseases of Bats 2017; Bats as possible animal origin of MERS-CoV
Investigator(s):	Lau SKP
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2017
Completion Date:	07/2017

List of Research Outputs

Researcher : Lau SKP

Project Title:	Molecular diversity and evolution of bat group C betacoronaviruses: implications on the origin of the novel human group C betacoronavirus
Investigator(s):	Lau SKP, Woo PCY, Zheng B
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	09/2013
Completion Date:	02/2017

Project Title:	Matrix-assisted laser desorption ionization time-of-flight mass spectrometry for rapid identification of Penicillium marneffei
Investigator(s):	Lau SKP, Woo PCY
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2015

Project Title:	Study of the genome evolution, interspecies transmission and pathogenicity of a novel animal picornavirus
Investigator(s):	Lau SKP, Woo PCY, Yuen KY
Department:	Microbiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2015

Project Title:	Genomic characterization of a novel rat bocaparvovirus from Norway rats in China
Investigator(s):	Lau SKP, Woo PCY
Department:	Microbiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2016

Project Title:	Characterization of mycoviruses in the thermally dimorphic fungus Talaromyces marneffei
Investigator(s):	Lau SKP, Woo PCY
Department:	Microbiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2017

Project Title:	2nd International Symposium on Infectious Diseases of Bats 2017; Bats as possible animal origin of MERS-CoV
Investigator(s):	Lau SKP
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2017
Completion Date:	07/2017

List of Research Outputs

Chan J.F.W., Sridhar S., Yip C.Y., Lau S.K.P. and Woo P.C.Y., The role of laboratory diagnostics in emerging viral infections: the example of the Middle East respiratory syndrome epidemic, Journal of Microbiology. 2017, 55: 172-182.

Chen Y., Chan K.H., Hong C., Kang Y., Ge S., Chen H., Wong Y.M., Joseph S., Patteril N.G., Wernery U., Xia N., Lau S.K.P. and Woo P.C.Y., A highly specific rapid antigen detection assay for on-site diagnosis of MERS., Journal of Infection. 2016, 73: 82-84.

Kong H.K., Law H.W., Liu X., Law C.O., Pan Q., Gao L., Xiong L., Lau S.K.P., Woo P.C.Y. and Lau T.C., Transcriptomic Analysis of Laribacter hongkongensis Reveals Adaptive Response Coupled with Temperature, PLoS One. 2017, 12: e0169998.

Lau S.K.P., Bats as potential animal origin of MERS coronavirus. , 2nd Bat Infectious Disease Symposium 2017. . 2017.

Lau S.K.P., Bats as potential animal origin of MERS coronavirus., 2nd bat infectious disease symposium 2017. (USA). 2017.

Lau S.K.P., Yeung C., Li K.S.M., Lam S.F., Cai J., Yuen M.C., Wang M., Zheng B., Woo P.C.Y. and Yuen K.Y., Identification and genomic characterization of a novel rat bocavirus from brown rats in China, Infection, Genetics and Evolution. 2017, 47: 68-76.

Lau S.K.P., Ahmed S.S., Yeung C., Li K.S.M., Fan Y.Y., Cheng T.Y., Cai J., Wang M., Zheng B., Wong S.S.Y., Woo P.C.Y. and Yuen K.Y., Identification and interspecies transmission of a novel bocaparvovirus among different bat species in China, The Journal of General Virology. 2016, 97: 3345-3358.

Lau S.K.P., Woo P.C.Y., Li K.S.M., Zhang H.J., Fan Y.Y., Zhang J., Chan B.C., Lam S.F., Yip C.Y., Yuen M.C., Chan K.H., Chen Z. and Yuen K.Y., Identification of Novel Rosavirus Species That Infects Diverse Rodent Species and Causes Multisystemic Dissemination in Mouse Model, PLoS Pathogen. 2016, 12: e1005911.

Lau S.K.P., Lo C.S., Lam C.S., Chow W.N., Ngan A.H., Wu A.K., Tsang D.N., Tse C.W., Que T.L., Tang B.S. and Woo P.C.Y., In Vitro Activity of Posaconazole against Talaromyces marneffei by Broth Microdilution and Etest Methods and Comparison to Itraconazole, Voriconazole, and Anidulafungin, Antimicrobial Agents and Chemotherapy. 2017, 61: e01480-16.

Lau S.K.P., Chan J.F.W., Hung F.N.I., Cheng V.C.C., Sridhar S., Yip C.Y., Chan K.H. and Woo P.C.Y., Middle East Respiratory Syndrome Interpreted: Human Herpesvirus 6B Pneumonia, The American Journal of Medicine. 2016, 129(9): 945-7.

Lau S.K.P., Wernery R., Wong Y.M., Joseph S., Tsang K.L., Patteril N.A., Elizabeth S.K., Chan K.H., Muhammed R., Kinne J., Yuen K.Y., Wernery U. and Woo P.C.Y., Polyphyletic origin of MERS coronaviruses and isolation of a novel clade A strain from dromedary camels in the United Arab Emirates, Emerging Microbes and Infections. 2016, 5: e128.

Lau S.K.P., Tsang C.C. and Woo P.C.Y., Talaromyces marneffei genomic, transcriptomic, proteomic and metabolomic studies reveal mechanisms for environmental adaptations and virulence, Toxins. 2017, 9: 192.

Lau S.Y., Joseph S., Chan K.H., Chen H., Patteril N.A., Elizabeth S.K., Muhammed R., Baskar V., Lau S.K.P., Kinne J., Wernery U. and Woo P.C.Y., Complete Genome Sequence of Influenza Virus H9N2 Associated with a Fatal Outbreak among Chickens in Dubai., Genome Announcement. 2016, 4: e00752-16.

Sridhar S., Teng L.L., Chiu T.H., Lau S.K.P. and Woo P.C.Y., Hepatitis E Virus Genotypes and Evolution: Emergence of Camel Hepatitis E Variants, International Journal of Molecular Sciences. 2017, 18: 869.

Sze K.H., Lam W.H., Zhang H., Ke Y., Tse M.K., Woo P.C.Y., Lau S.K.P., Lau C.Y., Cai J., Tung E.T., Lo R.K., Xu S., Kao R.Y.T., Hao Q. and Yuen K.Y., Talaromyces marneffei Mp1p Is a Virulence Factor that Binds and Sequesters a Key Proinflammatory Lipid to Dampen Host Innate Immune Response, Cell Chemical Biology. 2017, 24: 182-194.

TANG Y., Teng L.L., Cheung C.L., Ngan A.H., Huang Y., Wong S.S.Y., Yip E.K., Ng K.H., Que T.L., Lau S.K.P. and Woo P.C.Y., Tsukamurellaserpentis sp. nov., isolated from the oral cavity of Chinese cobras (Naja atra), International Journal of Systematic and Evolutionary Microbiology. 2016, 66: 3329-3336.

TSANG C.C., Chan J.F.W., Pong W.M., Chen H.K.J., Ngan A.H.Y., Cheung M., Lai C.K.C., Tsang D.N.C., Lau S.K.P. and Woo P.C.Y., Cutaneous hyalohyphomycosis due to Parengyodontium album gen. et comb. nov. , Medical Mycology. 2016, 54: 699-713.

TSANG C.C., Xiong L., Poon W.S.R., Chen H.K.J., Leung K.W., Lam J.Y.W., Wu K.L.A., Chan J.F.W., Lau S.K.P. and Woo P.C.Y., Gordonia hongkongensis sp. nov., isolated from blood culture and peritoneal dialysis effluent of patients in Hong Kong, International Journal of Systematic and Evolutionary Microbiology. 2016, 66: 3942-3950.

Tam W.T., TSANG C.C., Lau S.K.P. and Woo P.C.Y., Comparative mitogenomic and phylogenetic characterization on the complete mitogenomes of Talaromyces (Penicillium) marneffei , Mitochondrial DNA Part B. 2016, 1: 941-942.

Teng L.L., Tang Y., Huang Y., Guo F.B., Wei W., Chen J.H.H.K., Wong S.S.Y., Lau S.K.P. and Woo P.C.Y., Phylogenomic Analyses and Reclassification of Species within the Genus Tsukamurella: Insights to Species Definition in the Post-genomic Era, Frontiers in Microbiology. 2016, 7.

Teng L.L., Tang Y., Chiu T.H., Ngan A.H., Ngai C., Wong S.S.Y., Lau S.K.P. and Woo P.C.Y., The groEL gene is a promising target for species-level identification of Tsukamurella, Journal of Clinical Microbiology. American Society for Microbiology, 2017, 55: 649-653.

To K.K.W., Chan W.M., Li K.S.M., Lam S.F., Chen Z., Tse H., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., High prevalence of four novel astrovirus genotype species identified from rodents in China, Journal of General Virology. 2017, 98: 1004-1015.

Wernery U., Lau S.K.P. and Woo P.C.Y., Middle East respiratory syndrome (MERS) coronavirus and dromedaries, Veterinary Journal. 2017, 220: 75-79.

Woo P.C.Y., Wong Y.M., Wong B.H., Lam S.F., Fan Y.Y., Lau S.K.P. and Yuen K.Y., Comparative genome and evolutionary analysis of naturally occurring Beilong virus in brown and black rats., Infection, Genetics and Evolution. 2016, 45: 311-319.

Woo P.C.Y., Teng L.L., BAI R., Wong Y.P., Martelli P., Hui S.W., Tsang K.L., Lau C.Y., Ahmed S.S., Yip C.Y., CHOI K.Y., Li K.S.M., Lam S.F., Lau S.K.P. and Yuen K.Y., High Diversity of Genogroup I Picobirnaviruses in Mammals, Frontier in microbiology. 2016, 7: 1886.

Woo P.C.Y., Lau S.K.P., Choi G.K.Y., Hunag Y., Sivakumar S., Tsoi H.W., Yip C.C., Jose S.V., BAI R., Wong Y.M., Joesph M., Li T., Wernery U. and Yuen K.Y., Molecular epidemiology of canine picornavirus in Hong Kong and Dubai and proposal of a novel genus in Picornaviridae., Infect Genet Evol.. 2016, 41: 191-200.

Woo P.C.Y., Lau S.K.P., Lau C.Y., Tung T.K., Chong T.K., Yang F., Zhang H., Lo K.C., Cai J., Au Yeung K.H.R., Ng W.F., Tse H., Wong S.S.Y., Xu S., Lam W.H., Tse M.K., Sze K.H., Kao R.Y.T., Reiner N.E., Hao Q. and Yuen K.Y., Mp1p Is a Virulence Factor in Talaromyces (Penicillium) marneffei, PLOS Neglected Tropical Diseases. 2016, 10: e0004907.

Woo P.C.Y., Lau S.K.P., Teng L.L., Cao K.Y., Wernery U., Schountz T., Chiu T.H., Tsang K.L., Wong P.C., Wong Y.M. and Yuen K.Y., New Hepatitis E Virus Genotype in Bactrian Camels, Xinjiang, China, 2013, Emerging Infectious Diseases. 2016, 22: 2219-2221.

Woo P.C.Y., Lau S.K.P., Tsoi H.W., Patteril N.G., Yeung C., Joseph S., Wong Y.M., Muhammed R., Chow W.N., Wernery U. and Yuen K.Y., Two novel dromedary camel bocaparvoviruses from dromedaries in the Middle East with unique genomic features, The Journal of General Virology. 2017, 98: 1349-1359.

Woo P.C.Y., Lau S.K.P., Tsang C.C., Lau C.Y., Wong P.C., Chow W.N., Fong J.Y.H. and Yuen K.Y., Coronavirus HKU15 in respiratory tract of pigs and first discovery of coronavirus quasispecies in 5′-untranslated region, Emerging Microbes & Infections. 2017, 6: e53.

Xiong L., Yang Y., Ye Y.N., Teng L.L., Chan E., Watt R.M., Guo F.B., Lau S.K.P. and Woo P.C.Y., Laribacter hongkongensis anaerobic adaptation mediated by arginine metabolism is controlled by the cooperation of FNR and ArgR, Environmental Microbiology. 2017, 19: 1266-1280.

Yip C.Y., Lo J.Y.C., Sridhar S., Lung D.C., Luk S., Chan K.H., Chan J.F.W., Cheng C.C.V., Woo P.C.Y., Yuen K.Y. and Lau S.K.P., First Report of a Fatal Case Associated with EV-D68 Infection in Hong Kong and Emergence of an Interclade Recombinant in China Revealed by Genome Analysis, International Journal of Molecular Sciences. 2017, 18: e1065.

Researcher : Lau SY

List of Research Outputs

HUANG X., ZHENG M., Wang P., Mok B.W.Y., LIU S., Lau S.Y., CHEN P., Liu Y., LIU H., CHEN Y., Song W., Yuen K.Y. and Chen H., An NS-segment exonic splicing enhancer regulates influenza A virus replication in mammalian cells, Nature Communications. 2017, 8: 14751.

Lau S.Y., Joseph S., Chan K.H., Chen H., Patteril N.A., Elizabeth S.K., Muhammed R., Baskar V., Lau S.K.P., Kinne J., Wernery U. and Woo P.C.Y., Complete Genome Sequence of Influenza Virus H9N2 Associated with a Fatal Outbreak among Chickens in Dubai., Genome Announcement. 2016, 4: e00752-16.

Zheng M., Wang P., Lau S.Y., HUANG X., Mok B.W.Y., LIU S., LIU H., Liu Y. and Chen H., Characterization of mutations associated with cold adapted properties in DelNS1 influenza viruses; potential for new live attenuated influenza vaccine development , Options IX for The Control of Influenza, Chicago, USA, 24-28 Aug, 2016.

Researcher : Lee CY

List of Research Outputs

Lee C.Y., To K.K.W., Zhu H., Chu H., Mak W.N., Zhang J. and Yuen K.Y., Avian influenza virus A H7N9 infects multiple mononuclear cell types in peripheral blood and induces dysregulated cytokine responses and apoptosis in infected monocytes, Journal of General Virology. 2017, 98: 922-934.

Researcher : Lee MY

Project Title:	Direct identification and quantification of host and viral microRNAs after influenza infection using the next generation ultra-high throughput DNA sequencer
Investigator(s):	Lee MY, Lok S, Cheung CY
Department:	Microbiology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	05/2009

Project Title:	Determining the ligand and function of TLR10: a novel innate immune sensor in viral infection
Investigator(s):	Lee MY, Jin D, Peiris JSM
Department:	School of Public Health
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2014
Completion Date:	09/2016

Project Title:	Determining the involvement of TLR10-a novel innate immune sensor in influenza virus pathogenesis
Investigator(s):	Lee MY, Sanyal S
Department:	School of Public Health
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2016
Completion Date:	02/2017

Project Title:	International Congress of Immunology 2016 (ICI-2016); TLR10 as an innate receptor
Investigator(s):	Lee MY
Department:	School of Public Health
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2016
Completion Date:	08/2016

Project Title:	Innate lymphoid cell "adaptation" during influenza virus infection
Investigator(s):	Lee MY, Peiris JSM, Cowling BJ, Bruzzone R
Department:	School of Public Health
Source(s) of Funding:	France/Hong Kong Joint Research Scheme - Travel Grants
Start Date:	01/2017

Project Title:	Effect of Volatile Organic Compounds (VOCs) exposure on disease severity in influenza virus infection
Investigator(s):	Lee MY, Yan S
Department:	School of Public Health
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2017

Researcher : Lee WM

List of Research Outputs

Cheng C.C.V., Chen H.K.J., So S.Y.C., Wong C.Y.S., Chau P.H., Wong M.W.L., Ching H.C.R., Ng L.M.M., Lee W.M., Hung F.N.I., Ho P.L. and Yuen K.Y., A novel risk factor associated with colonization by Carbapenemase-Producing Enterobacteriaceae: Use of Proton Pump Inhibitors in addition to Antimicrobial Treatment, Infection Control & Hospital Epidemiology. 2016, 37: 1418-1425.

Cheng C.C.V., Wong S.C., Wong I.W.Y., Chau P.H., So S.Y.C., Wong C.Y.S., Chen H.K.J., Lee W.M., Tai J.W.M., Chau C.H., Lo W.K. and Yuen K.Y., The challenge of patient empowerment in hand hygiene promotion in health care facilities in Hong Kong, American Journal of Infection Control. 2017, 45: 562-565.

Researcher : Leung ASP

List of Research Outputs

Chan C.M., Chu H., Wang Y., Wong H.Y.B., Zhao X., Zhou J., Yang D., Leung A.S.P., Chan J.F.W., Yeung M.L., Yan J., Lu G., Gao G.F. and Yuen K.Y., Carcinoembryonic Antigen-related Cell Adhesion Molecule 5 (CEACAM5) Is an Important Surface Attachment Factor Facilitating the Entry of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV), Journal of Virology. 2016, JVI.01133-16.

Researcher : Li C

Project Title:	2nd International conference on Flu & Emerging Infectious Diseases; TLR7 agonist imiquimod enhances the efficacy of 2009 Pandemic H1N1 Vaccine in BALB/c mice
Investigator(s):	Li C
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/2016
Completion Date:	11/2016

Researcher : Li C

List of Research Outputs

HU M., Chu H., Zhang K., SINGH K., Li C., Yuan S., Chow B.K.C., Song W., Zhou J. and Zheng B., Amino acid substitutions V63I or A37S/I61T/V63I/V100A in the PA N-terminal domain increase the virulence of H7N7 influenza A virus, Scientific Reports. ENGLAND, Nature Publishing Group, 2016, 6: 37800.

Hu M., Yuan S., Ye Z., SINGH K., Li C., SHUAI H., Ng F., Chow B.K.C., Chu H. and Zheng B., PA N substitutions A37S, A37S/I61T and A37S/V63I attenuate the replication of H7N7 influenza A virus by impairing the polymerase and endonuclease activities, Journal of General Virology. 2017, 98: 364-373.

Ye Z., Yuan S., Poon K.M., Wen L.R., Yang D., Sun Z., Li C., Hu M., Shuai H., Zhou J., Zhang M., Zheng B., Chu H. and Yuen K.Y., Antibody-Dependent Cell-Mediated Cytotoxicity Epitopes on the Hemagglutinin Head Region of Pandemic H1N1 Influenza Virus Play Detrimental Roles in H1N1-Infected Mice, Frontiers in Immunology. Frontiers, 2017, 8: 317.

Researcher : Li KSM

List of Research Outputs

Lau S.K.P., Yeung C., Li K.S.M., Lam S.F., Cai J., Yuen M.C., Wang M., Zheng B., Woo P.C.Y. and Yuen K.Y., Identification and genomic characterization of a novel rat bocavirus from brown rats in China, Infection, Genetics and Evolution. 2017, 47: 68-76.

Lau S.K.P., Ahmed S.S., Yeung C., Li K.S.M., Fan Y.Y., Cheng T.Y., Cai J., Wang M., Zheng B., Wong S.S.Y., Woo P.C.Y. and Yuen K.Y., Identification and interspecies transmission of a novel bocaparvovirus among different bat species in China, The Journal of General Virology. 2016, 97: 3345-3358.

Lau S.K.P., Woo P.C.Y., Li K.S.M., Zhang H.J., Fan Y.Y., Zhang J., Chan B.C., Lam S.F., Yip C.Y., Yuen M.C., Chan K.H., Chen Z. and Yuen K.Y., Identification of Novel Rosavirus Species That Infects Diverse Rodent Species and Causes Multisystemic Dissemination in Mouse Model, PLoS Pathogen. 2016, 12: e1005911.

To K.K.W., Chan W.M., Li K.S.M., Lam S.F., Chen Z., Tse H., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., High prevalence of four novel astrovirus genotype species identified from rodents in China, Journal of General Virology. 2017, 98: 1004-1015.

Woo P.C.Y., Teng L.L., BAI R., Wong Y.P., Martelli P., Hui S.W., Tsang K.L., Lau C.Y., Ahmed S.S., Yip C.Y., CHOI K.Y., Li K.S.M., Lam S.F., Lau S.K.P. and Yuen K.Y., High Diversity of Genogroup I Picobirnaviruses in Mammals, Frontier in microbiology. 2016, 7: 1886.

Researcher : Li PCK

List of Research Outputs

Hung F.N.I., To K.K.W., Chan J.F.W., Cheng C.C.V., Liu S.H.K., Tam A., Chan T.C.I., Zhang J., Li P.C.K., Wong T.L., ZHANG R., Cheung M.K.S., Leung W., Lau J.Y., Fok M., Chen H., Chan K.H. and Yuen K.Y., Efficacy of Clarithromycin-Naproxen-Oseltamivir Combination in the Treatment of Patients Hospitalized for Influenza A(H3N2) Infection: an open-label, randomized controlled, phase 2b/3 trial., Chest. 2017, 151: 1069-1080.

Researcher : Li T

List of Research Outputs

Woo P.C.Y., Lau S.K.P., Choi G.K.Y., Hunag Y., Sivakumar S., Tsoi H.W., Yip C.C., Jose S.V., BAI R., Wong Y.M., Joesph M., Li T., Wernery U. and Yuen K.Y., Molecular epidemiology of canine picornavirus in Hong Kong and Dubai and proposal of a novel genus in Picornaviridae., Infect Genet Evol.. 2016, 41: 191-200.

Researcher : Li Y

List of Research Outputs

WU X., Liu L., Cheung K.W., Wang H., Lu X., Cheung K.L.A., LIU W., Huang X., Li Y., Chen Z., CHEN S.M.Y., Zhang T., Wu H. and Chen Z., Brain Invasion by CD4+ T Cells Infected with a Transmitted/Founder HIV-1BJZS7 During Acute Stage in Humanized Mice, Journal of Neuroimmune Pharmacology. 2016, 11: 572-583.

Researcher : Liu L

Project Title:	Early HIV-1 diagnosis using in-house real-time PCR amplification on dried blood spots for men who have sex with men in Hong Kong
Investigator(s):	Liu L
Department:	LKS Medical Faculty
Source(s) of Funding:	Council for the AIDS Trust Fund - General Award
Start Date:	09/2009

Project Title:	Molecular mechanisms of Nef mediated regulation of PD-1 expression during HIV/SIV infection
Investigator(s):	Liu L, Chen Z
Department:	LKS Medical Faculty
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	02/2014

Project Title:	Defining the role of monocyte-derived dendritic cells in potentiating durable and protective T-cell immunity by a newly identified PD-1 isoform
Investigator(s):	Liu L, Chen Z
Department:	LKS Medical Faculty
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2015

Project Title:	Mechanisms of viral evasion of vaccine induced T cell immune response
Investigator(s):	Liu L
Department:	Microbiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

Project Title:	Therapeutic potential of regulatory T cells in limiting HIV reservoir in the brain without triggering detrimental neuroinflammation
Investigator(s):	Liu L, Chen Z
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2017

Project Title:	Immunology 2017; Anti-spike IgG exacerbates lung injury by skewing monocyte-macrophage responses during SARS-CoV infection
Investigator(s):	Liu L
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2017
Completion Date:	05/2017

Project Title:	Role of Δ42PD-1 in B-cell dysfunction during HIV infection
Investigator(s):	Liu L
Department:	Microbiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

List of Research Outputs

Liu L., Wang H. and Chen Z., Anti-spike IgG exacerbates lung injury by skewing monocyte-macrophage responses during SARS-CoV infection, IMMUNOLOGY 2017.

Liu L., Peng J. and Chen Z., Role of myeloid derived suppressive cells on EcoHIV evasion from vaccine induced T cell immune response. South Africa, International AIDS Conference 2016.

Liu L., Wei Q., Nishiura K., PENG J., Wang H., Midkiff C., Alvarez X., Qin C., Lackner A. and Chen Z., Spatiotemporal interplay of severe acute respiratory syndrome coronavirus and respiratory mucosal cells drives viral dissemination in rhesus macaques, Mucosal Immunology. 2016, 9: 1089-1101.

Tang L., Guo J., Cheng L., Sun C., Liu L., Zuo T., Wang H., Cheng L., Zhang L. and Chen Z., Single N277A substitution in C2 of simian immunodeficiency virus envelope influences vaccine-elicited CD4i neutralizing and anti-V2 antibody responses, Vaccine. 2017, 35: 2582-2591.

WU X., Liu L., Cheung K.W., Wang H., Lu X., Cheung K.L.A., LIU W., Huang X., Li Y., Chen Z., CHEN S.M.Y., Zhang T., Wu H. and Chen Z., Brain Invasion by CD4+ T Cells Infected with a Transmitted/Founder HIV-1BJZS7 During Acute Stage in Humanized Mice, Journal of Neuroimmune Pharmacology. 2016, 11: 572-583.

Wei Q., Liu L., Cong Z., Wu X., Wang H., Qin C.H.U.N.-.C.H.U.N.G., Molina P. and Chen Z., Chronic Δ9-Tetrahydrocannabinol Administration Reduces IgE+B Cells but Unlikely Enhances Pathogenic SIVmac251 Infection in Male Rhesus Macaques of Chinese Origin, Journal of Neuroimmune Pharmacology. 2016, 11: 584-591.

Researcher : Liu Y

Project Title:	Options IX for the control of Influenza ; The role of the cellular 5'-3' mRNA exonuclease, Xrn1, in influenza A virus replication
Investigator(s):	Liu Y
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2016
Completion Date:	08/2016

List of Research Outputs

HUANG X., ZHENG M., Wang P., Mok B.W.Y., LIU S., Lau S.Y., CHEN P., Liu Y., LIU H., CHEN Y., Song W., Yuen K.Y. and Chen H., An NS-segment exonic splicing enhancer regulates influenza A virus replication in mammalian cells, Nature Communications. 2017, 8: 14751.

Zheng M., Wang P., Lau S.Y., HUANG X., Mok B.W.Y., LIU S., LIU H., Liu Y. and Chen H., Characterization of mutations associated with cold adapted properties in DelNS1 influenza viruses; potential for new live attenuated influenza vaccine development , Options IX for The Control of Influenza, Chicago, USA, 24-28 Aug, 2016.

Researcher : Lo CS

List of Research Outputs

Lau S.K.P., Lo C.S., Lam C.S., Chow W.N., Ngan A.H., Wu A.K., Tsang D.N., Tse C.W., Que T.L., Tang B.S. and Woo P.C.Y., In Vitro Activity of Posaconazole against Talaromyces marneffei by Broth Microdilution and Etest Methods and Comparison to Itraconazole, Voriconazole, and Anidulafungin, Antimicrobial Agents and Chemotherapy. 2017, 61: e01480-16.

Researcher : Lo KC

List of Research Outputs

Woo P.C.Y., Lau S.K.P., Lau C.Y., Tung T.K., Chong T.K., Yang F., Zhang H., Lo K.C., Cai J., Au Yeung K.H.R., Ng W.F., Tse H., Wong S.S.Y., Xu S., Lam W.H., Tse M.K., Sze K.H., Kao R.Y.T., Reiner N.E., Hao Q. and Yuen K.Y., Mp1p Is a Virulence Factor in Talaromyces (Penicillium) marneffei, PLOS Neglected Tropical Diseases. 2016, 10: e0004907.

Researcher : Lo WU

List of Research Outputs

Ho P.L., LIU C., Chow K.H., Tse C.W., Lo W.U., Mak S.K. and Lo W.K., Emergence of ileS2 -Carrying, Multidrug-Resistant Plasmids in Staphylococcus lugdunensis , Antimicrobial Agents and Chemotherapy. 2016, 60: 6411-6414.

WANG Y., Lo W.U., Lai R.W., Tsw C.W., Lee R.A., Luk W.K., Cheng C.C.V., Que T.L., Chow K.H. and Ho P.L., IncN ST7 epidemic plasmid carrying bla IMP-4 in Enterobacteriaceae isolates with epidemiological links to multiple geographical areas in China , Journal of Antimicrobial Chemotherapy. 2017, 72: 99-103.

WANG Y., Lo W.U., Yau C.Y., Chow K.H. and Ho P.L., Impact of intraobserver and interobserver variation on performance of the CLSI Carba NP assay for carbapenemase detection in Enterobacteriaceae, Journal of Global Antimicrobial Resistance. 2017, 9: 19-20.

Researcher : Lu L

List of Research Outputs

To K.K.W., Lu L., Yip C.Y., Poon W.S.R., Fung A.M.Y., Cheng A., Lui D.H.K., Ho T.Y., Hung F.N.I., Chan K.H. and Yuen K.Y., Additional molecular testing of saliva specimens improves the detection of respiratory viruses, Emerging Microbes & Infections. 2017, 6: e49.

To K.K.W., Lu L., Hung F.N.I. and Yuen K.Y., Host response of rhinovirus infection among hospitalized adult patients, American Society for Virology 36th Annual Meeting. 2017.

Researcher : Mak WN

List of Research Outputs

Chan J.F.W., Zhang J., Chan C.S., Yip C.Y., Mak W.N., Zhu H., Poon K.M., Tee K.M., Zhu Z., Cai J., Tsang O.L., Chik K.K.H., Yin F., Chan K.H., Kok K.H., Jin D., Au Yeung K.H.R. and Yuen K.Y., Characterization of a novel mouse model for Zika virus infection using dexamethasone-immunosuppressed mice, First International Conference on Zika Virus. 2017.

Chan J.F.W., Chan K.H., Yuan S., CHIK K.K.H., ZHU Z., Tee K.M., TSANG O.L., Yip C.Y., Poon K.M., Chan C.S., Mak W.N., Zhang J. and Yuen K.Y., Development of an in ovo system for evaluation of antivirals against Zika virus, 30th International Conference on Antiviral Research (ICAR). 2017.

Chan J.F.W., Zhang J., Chan C.S., Yip C.Y., Mak W.N., Zhu H., Poon K.M., Tee K.M., Zhu Z., Cai J., Tsang O.L., Chik K.K.H., Yin F., Chan K.H., Kok K.H., Jin D., Au Yeung K.H.R. and Yuen K.Y., Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons, EBioMedicine. 2016, 14: 112-122.

Lee C.Y., To K.K.W., Zhu H., Chu H., Mak W.N., Zhang J. and Yuen K.Y., Avian influenza virus A H7N9 infects multiple mononuclear cell types in peripheral blood and induces dysregulated cytokine responses and apoptosis in infected monocytes, Journal of General Virology. 2017, 98: 922-934.

Researcher : Mok BWY

Project Title:	The role of influenza virus NS1 in miR-146a-mediated regulation of the innate immune response
Investigator(s):	Mok BWY, Chen H
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2014

Project Title:	Exploring the role of influenza virus NS1 in microRNA-mediated regulation of the innate immune response
Investigator(s):	Mok BWY, Chen H
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	08/2015

List of Research Outputs

Chen H., Verhoeven R., TONG S. and Mok B.W.Y., Epstein-Barr virus BART noncoding RNAs modulate host gene expression for virus latency leading to oncogenesis in epithelial cells, AACR annual meeting . 2017.

HUANG X., ZHENG M., Wang P., Mok B.W.Y., LIU S., Lau S.Y., CHEN P., Liu Y., LIU H., CHEN Y., Song W., Yuen K.Y. and Chen H., An NS-segment exonic splicing enhancer regulates influenza A virus replication in mammalian cells, Nature Communications. 2017, 8: 14751.

Zheng M., Wang P., Lau S.Y., HUANG X., Mok B.W.Y., LIU S., LIU H., Liu Y. and Chen H., Characterization of mutations associated with cold adapted properties in DelNS1 influenza viruses; potential for new live attenuated influenza vaccine development , Options IX for The Control of Influenza, Chicago, USA, 24-28 Aug, 2016.

Researcher : Ng F

List of Research Outputs

Hu M., Yuan S., Ye Z., SINGH K., Li C., SHUAI H., Ng F., Chow B.K.C., Chu H. and Zheng B., PA N substitutions A37S, A37S/I61T and A37S/V63I attenuate the replication of H7N7 influenza A virus by impairing the polymerase and endonuclease activities, Journal of General Virology. 2017, 98: 364-373.

Researcher : Ng LMM

List of Research Outputs

Cheng C.C.V., Chen H.K.J., So S.Y.C., Wong C.Y.S., Chau P.H., Wong M.W.L., Ching H.C.R., Ng L.M.M., Lee W.M., Hung F.N.I., Ho P.L. and Yuen K.Y., A novel risk factor associated with colonization by Carbapenemase-Producing Enterobacteriaceae: Use of Proton Pump Inhibitors in addition to Antimicrobial Treatment, Infection Control & Hospital Epidemiology. 2016, 37: 1418-1425.

Researcher : Ng SP

Project Title:	Collection of background information on the alternative faecal indicators in the environmental waters of Hong Kong and their correlation with Escherichia coli
Investigator(s):	Ng SP, Yam WC
Department:	Microbiology
Source(s) of Funding:	Environment Protection Department - General Award
Start Date:	06/2001

Researcher : Nishiura K

List of Research Outputs

Liu L., Wei Q., Nishiura K., PENG J., Wang H., Midkiff C., Alvarez X., Qin C., Lackner A. and Chen Z., Spatiotemporal interplay of severe acute respiratory syndrome coronavirus and respiratory mucosal cells drives viral dissemination in rhesus macaques, Mucosal Immunology. 2016, 9: 1089-1101.

Researcher : PENG J

List of Research Outputs

Liu L., Peng J. and Chen Z., Role of myeloid derived suppressive cells on EcoHIV evasion from vaccine induced T cell immune response. South Africa, International AIDS Conference 2016.

Liu L., Wei Q., Nishiura K., PENG J., Wang H., Midkiff C., Alvarez X., Qin C., Lackner A. and Chen Z., Spatiotemporal interplay of severe acute respiratory syndrome coronavirus and respiratory mucosal cells drives viral dissemination in rhesus macaques, Mucosal Immunology. 2016, 9: 1089-1101.

Researcher : Peiris JSM

Project Title:	IV International Symposium on Respiratory Viral Infections The Influenza Disease Burden in Hong Kong: the Rates of Hospitalisation in Children
Investigator(s):	Peiris JSM
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2001

Project Title:	Influenza pandemic preparedness in Asia (Research collaboration with national Institute of Allergy and Infectious Diseases (NIAID), St. Jude Children's Research Hospital, Inc. (SJCRH) and The University of Hong Kong)
Investigator(s):	Peiris JSM, Guan Y
Department:	Microbiology
Source(s) of Funding:	National Institutes of Health, US Department of Health and Human Services - General Award
Start Date:	04/2003

Project Title:	Virus-cell interaction and the pathogenesis of SARS
Investigator(s):	Peiris JSM
Department:	Microbiology
Source(s) of Funding:	VCO SARS Research Fund
Start Date:	07/2003

Project Title:	Viral determinants underlying the increased secretion of pro-inflammatory cytokines in H5N1 infected human macrophages: a mechanism for the unusual severity of human H5N1 disease?
Investigator(s):	Peiris JSM, Guan Y, Lau ASY, Poon LML
Department:	Microbiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2003

Project Title:	Outstanding Researcher Award 2003-2004
Investigator(s):	Peiris JSM
Department:	School of Public Health
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	07/2004

Project Title:	Special Research Achievement Award 2003-2004
Investigator(s):	Peiris JSM
Department:	School of Public Health
Source(s) of Funding:	Special Research Achievement Award
Start Date:	11/2004

Project Title:	The macrophage in the pathogenesis of Severe Acute Respiratory Syndrome Coronavirus infection
Investigator(s):	Peiris JSM
Department:	Microbiology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	12/2005

Project Title:	The pathogenesis of avian influenza A H5N1 in humans: macrophage and epithelial cell-virus interactions in vitro and ex-vivo
Investigator(s):	Peiris JSM
Department:	Microbiology
Source(s) of Funding:	The Wellcome Trust - General Award
Start Date:	01/2007

Project Title:	Communicable Diseases Surveillance and Response (CSR) - Standardization and shipment of PCR diagnostic kit for Avian Influenza detection to Member countries (viz: Bangladesh, Indonesia, Myanmar, Sri Lanka and Thailand)
Investigator(s):	Peiris JSM
Department:	Microbiology
Source(s) of Funding:	Collaborating Project Fund
Start Date:	06/2007

Project Title:	Control of Pandemic and Inter-pandemic Influenza
Investigator(s):	Peiris JSM, Guan Y, Yuen KY, Chen H, Leung GM, Lau YL
Department:	Microbiology
Source(s) of Funding:	Areas of Excellence Scheme
Start Date:	01/2008

Project Title:	Host responses that correlate with respiratory droplet transmission of swine-origin influenza viruses in ferrets
Investigator(s):	Peiris JSM, Yen H, Nicholls JM
Department:	School of Public Health
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	10/2013
Completion Date:	11/2016

Project Title:	Viral, Host and Environmental Determinants of Influenza Virus Transmission and Pathogenesis
Investigator(s):	Peiris JSM, Cowling BJ, Guan Y, Li Y, Nicholls JM, Poon LML, Tu W, Yen H, Zhu H, Chan MCW, Lam TY, Jin D, Lee MY, Sanyal S, Mok KP, Sham PC
Department:	School of Public Health
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	01/2015

Project Title:	Public Health Responses to threats of emerging, epidemic and endemic infectious diseases
Investigator(s):	Peiris JSM, Cowling BJ, Wu JTK, Guan Y
Department:	School of Public Health
Source(s) of Funding:	Commissioned Research on Control of Infectious Diseases (Phase III)
Start Date:	01/2015

Project Title:	Role of influenza virus surface glycoproteins in virus-induced cell stress and inflammation
Investigator(s):	Peiris JSM, Yen H
Department:	School of Public Health
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2015

Project Title:	HKU Centennial Distinguished Chinese Scholars Scheme 2015-16
Investigator(s):	Peiris JSM
Department:	School of Public Health
Source(s) of Funding:	HKU Centennial Distinguished Chinese Scholars Scheme
Start Date:	09/2015

Project Title:	Transmission of respiratory viruses: from basic science to evidence based options for control
Investigator(s):	Peiris JSM
Department:	School of Public Health
Source(s) of Funding:	Croucher Foundation - Conference / Seminars
Start Date:	06/2017

Researcher : Poon KM

List of Research Outputs

Chan J.F.W., Zhang J., Chan C.S., Yip C.Y., Mak W.N., Zhu H., Poon K.M., Tee K.M., Zhu Z., Cai J., Tsang O.L., Chik K.K.H., Yin F., Chan K.H., Kok K.H., Jin D., Au Yeung K.H.R. and Yuen K.Y., Characterization of a novel mouse model for Zika virus infection using dexamethasone-immunosuppressed mice, First International Conference on Zika Virus. 2017.

Chan J.F.W., Chan K.H., Yuan S., CHIK K.K.H., ZHU Z., Tee K.M., TSANG O.L., Yip C.Y., Poon K.M., Chan C.S., Mak W.N., Zhang J. and Yuen K.Y., Development of an in ovo system for evaluation of antivirals against Zika virus, 30th International Conference on Antiviral Research (ICAR). 2017.

Chan J.F.W., Yip C.Y., Tee K.M., Zhu Z., Tsang O.L., Chik K.K.H., TSANG G.W.T., Chan C.S., Poon K.M., Sridhar S., Yin F., Hung F.N.I., Chau S.K.Y., Zhang J., Chan K.H. and Yuen K.Y., Improved detection of Zika virus RNA in human and animal specimens by a novel, highly sensitive and specific real-time RT-PCR assay targeting the 5′-untranslated region of Zika virus, Tropical Medicine & International Health. 2017, 22: 594-603.

Chan J.F.W., CHIK K.K.H., Yuan S., Yip C.Y., ZHU Z., Tee K.M., TSANG O.L., Chan C.S., Poon K.M., Lu G., Zhang J., Lai K.K., Chan K.H., Kao R.Y.T. and Yuen K.Y., Novel antiviral activity and mechanism of bromocriptine as a Zika virus NS2B-NS3 protease inhibitor, Antiviral Research. 2017, 141: 29-37.

Chan J.F.W., Zhang J., Chan C.S., Yip C.Y., Mak W.N., Zhu H., Poon K.M., Tee K.M., Zhu Z., Cai J., Tsang O.L., Chik K.K.H., Yin F., Chan K.H., Kok K.H., Jin D., Au Yeung K.H.R. and Yuen K.Y., Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons, EBioMedicine. 2016, 14: 112-122.

Ye Z., Yuan S., Poon K.M., Wen L.R., Yang D., Sun Z., Li C., Hu M., Shuai H., Zhou J., Zhang M., Zheng B., Chu H. and Yuen K.Y., Antibody-Dependent Cell-Mediated Cytotoxicity Epitopes on the Hemagglutinin Head Region of Pandemic H1N1 Influenza Virus Play Detrimental Roles in H1N1-Infected Mice, Frontiers in Immunology. Frontiers, 2017, 8: 317.

Yip C.Y., Tee K.M., Zhu Z., Chik K.K.H., Tsang O.L., Poon K.M., Chan C.S., Zhang J., Chan K.H., Yuen K.Y. and Chan J.F.W., Development and evaluation of a novel real-time RT-PCR assay targeting the envelope gene of the African and Asian/American lineages of the emerging Zika virus, 3rd Microbiology Asia Congress. 2016.

Yip C.Y., Tee K.M., ZHU Z., TSANG O.L., CHIK K.K.H., TSANG G.W.T., Chan C.S., Poon K.M., Sridhar S., Yin F., Hung F.N.I., Chau S.K.Y., Zhang J., Chan K.H., Yuen K.Y. and Chan J.F.W., Improved detection of Zika virus RNA in human and animal specimens by a novel, highly sensitive and specific real-time RT-PCR assay targeting the 5'-untranslated region of Zika virus, 33rd ASM Clinical Virology Symposium. 2017.

Researcher : Poon LLM

Project Title:	Reverse genetic for a coronavirus responsible for severe acute respiratory syndrome
Investigator(s):	Poon LML, Guan Y
Department:	Microbiology
Source(s) of Funding:	VCO SARS Research Fund
Start Date:	07/2003

Project Title:	International Conference on Options for Control of Influenza V Genetic Characterization of a Novel Coronavirus Responsible for Severe Acute Respiratory Syndrome A Coronavirus Responsible for Severe Acute Respiratory Syndrome
Investigator(s):	Poon LML
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/2003

Project Title:	Centre for Research into Circulating Fetal Nucleic Acids
Investigator(s):	Poon LML
Department:	Microbiology
Source(s) of Funding:	Areas of Excellence Scheme
Start Date:	01/2008

Project Title:	Generation of a replication-incompetent NP-knockout influenza virus that allows expression of galactose-alpha-1,3-galactose (alpha-Gal) in infected cells to enhance adaptive immune response
Investigator(s):	Poon LML, Doak SA
Department:	School of Public Health
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2015

Project Title:	Vaccination scheme development to stimulate both B and T cell dependent heterosubtypic protection against Influenza A viruses in mice
Investigator(s):	Poon LML, Doak SA
Department:	School of Public Health
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2015

Project Title:	Detection and characterization of antibody-dependent cell-mediated cytotoxicity (ADCC) responses against human H7N9 virus in humans and mice
Investigator(s):	Poon LML, Doak SA
Department:	School of Public Health
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2016

Researcher : Poon WSR

List of Research Outputs

Chan J.F.W., Tee K.M., CHOI K.Y., Zhu Z., Poon W.S.R., Ng K.T.P., Chan K.H., Hung F.N.I., Man K. and Yuen K.Y., First detection and complete genome sequence of a phylogenetically distinct human polyomavirus 6 highly prevalent in human bile samples, Journal of Infection. 2017, 74: 50-59.

TSANG C.C., Xiong L., Poon W.S.R., Chen H.K.J., Leung K.W., Lam J.Y.W., Wu K.L.A., Chan J.F.W., Lau S.K.P. and Woo P.C.Y., Gordonia hongkongensis sp. nov., isolated from blood culture and peritoneal dialysis effluent of patients in Hong Kong, International Journal of Systematic and Evolutionary Microbiology. 2016, 66: 3942-3950.

To K.K.W., Lu L., Yip C.Y., Poon W.S.R., Fung A.M.Y., Cheng A., Lui D.H.K., Ho T.Y., Hung F.N.I., Chan K.H. and Yuen K.Y., Additional molecular testing of saliva specimens improves the detection of respiratory viruses, Emerging Microbes & Infections. 2017, 6: e49.

Researcher : SHUAI H

List of Research Outputs

Hu M., Yuan S., Ye Z., SINGH K., Li C., SHUAI H., Ng F., Chow B.K.C., Chu H. and Zheng B., PA N substitutions A37S, A37S/I61T and A37S/V63I attenuate the replication of H7N7 influenza A virus by impairing the polymerase and endonuclease activities, Journal of General Virology. 2017, 98: 364-373.

Ye Z., Yuan S., Poon K.M., Wen L.R., Yang D., Sun Z., Li C., Hu M., Shuai H., Zhou J., Zhang M., Zheng B., Chu H. and Yuen K.Y., Antibody-Dependent Cell-Mediated Cytotoxicity Epitopes on the Hemagglutinin Head Region of Pandemic H1N1 Influenza Virus Play Detrimental Roles in H1N1-Infected Mice, Frontiers in Immunology. Frontiers, 2017, 8: 317.

Zhao H., Chu H., Zhao X., SHUAI H., Wong H.Y.B., Wen L.R., Yuan S., Zheng B., Zhou J. and Yuen K.Y., Novel residues in the PA protein of avian influenza H7N7 virus affect virulence in mammalian hosts, Virology. 2016, 498: 1-8.

Researcher : Shuai H

List of Research Outputs

Researcher : Smith GJ

Project Title:	Research into the ecology, evolution and population genetics of influenza A (H5N1) virus
Investigator(s):	Smith GJ
Department:	Microbiology
Source(s) of Funding:	National Institutes of Health, US Department of Health and Human Services - General Award
Start Date:	05/2007

Project Title:	Outstanding Young Researcher Award 2008-2009
Investigator(s):	Smith GJ
Department:	Microbiology
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	12/2009

Researcher : Song W

List of Research Outputs

HU M., Chu H., Zhang K., SINGH K., Li C., Yuan S., Chow B.K.C., Song W., Zhou J. and Zheng B., Amino acid substitutions V63I or A37S/I61T/V63I/V100A in the PA N-terminal domain increase the virulence of H7N7 influenza A virus, Scientific Reports. ENGLAND, Nature Publishing Group, 2016, 6: 37800.

HUANG X., ZHENG M., Wang P., Mok B.W.Y., LIU S., Lau S.Y., CHEN P., Liu Y., LIU H., CHEN Y., Song W., Yuen K.Y. and Chen H., An NS-segment exonic splicing enhancer regulates influenza A virus replication in mammalian cells, Nature Communications. 2017, 8: 14751.

Researcher : Sridhar S

List of Research Outputs

Chan J.F.W., Yip C.Y., Tsang O.L., Tee K.M., Cai J., Chik K.K.H., Zhu Z., Chan C.S., CHOI K.Y., Sridhar S., Zhang J., Lu G., Chiu K., Lo A.C.Y., Tsao G.S.W., Kok K.H., Jin D., Chan K.H. and Yuen K.Y., Differential cell line susceptibility to the emerging Zika virus: implications for disease pathogenesis, non-vector-borne human transmission and animal reservoirs, Emerging Microbes & Infections. 2016, 5: e93.

Chan J.F.W., Yip C.Y., Tee K.M., Zhu Z., Tsang O.L., Chik K.K.H., TSANG G.W.T., Chan C.S., Poon K.M., Sridhar S., Yin F., Hung F.N.I., Chau S.K.Y., Zhang J., Chan K.H. and Yuen K.Y., Improved detection of Zika virus RNA in human and animal specimens by a novel, highly sensitive and specific real-time RT-PCR assay targeting the 5′-untranslated region of Zika virus, Tropical Medicine & International Health. 2017, 22: 594-603.

Chan J.F.W., Sridhar S., Yip C.Y., Lau S.K.P. and Woo P.C.Y., The role of laboratory diagnostics in emerging viral infections: the example of the Middle East respiratory syndrome epidemic, Journal of Microbiology. 2017, 55: 172-182.

Lau S.K.P., Chan J.F.W., Hung F.N.I., Cheng V.C.C., Sridhar S., Yip C.Y., Chan K.H. and Woo P.C.Y., Middle East Respiratory Syndrome Interpreted: Human Herpesvirus 6B Pneumonia, The American Journal of Medicine. 2016, 129(9): 945-7.

Sridhar S., Teng L.L., Chiu T.H., Lau S.K.P. and Woo P.C.Y., Hepatitis E Virus Genotypes and Evolution: Emergence of Camel Hepatitis E Variants, International Journal of Molecular Sciences. 2017, 18: 869.

Yip C.Y., Lo J.Y.C., Sridhar S., Lung D.C., Luk S., Chan K.H., Chan J.F.W., Cheng C.C.V., Woo P.C.Y., Yuen K.Y. and Lau S.K.P., First Report of a Fatal Case Associated with EV-D68 Infection in Hong Kong and Emergence of an Interclade Recombinant in China Revealed by Genome Analysis, International Journal of Molecular Sciences. 2017, 18: e1065.

Yip C.Y., Tee K.M., ZHU Z., TSANG O.L., CHIK K.K.H., TSANG G.W.T., Chan C.S., Poon K.M., Sridhar S., Yin F., Hung F.N.I., Chau S.K.Y., Zhang J., Chan K.H., Yuen K.Y. and Chan J.F.W., Improved detection of Zika virus RNA in human and animal specimens by a novel, highly sensitive and specific real-time RT-PCR assay targeting the 5'-untranslated region of Zika virus, 33rd ASM Clinical Virology Symposium. 2017.

Researcher : Sun Z

List of Research Outputs

Ye Z., Yuan S., Poon K.M., Wen L.R., Yang D., Sun Z., Li C., Hu M., Shuai H., Zhou J., Zhang M., Zheng B., Chu H. and Yuen K.Y., Antibody-Dependent Cell-Mediated Cytotoxicity Epitopes on the Hemagglutinin Head Region of Pandemic H1N1 Influenza Virus Play Detrimental Roles in H1N1-Infected Mice, Frontiers in Immunology. Frontiers, 2017, 8: 317.

Researcher : Sze KH

Project Title:	XXIInd International Conference on Magnetic Resonance in Biological Systems (ICMRBS 2006) Backbone Dynamics and Solution Structure of a Thermophilic Acylphosphatase from Pyrococcus Horikoshii by NMR Spectroscopy
Investigator(s):	Sze KH
Department:	Chemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2006

Project Title:	Characterization of Staphylococcus aureus virulence factor EsxA and structure-based screening of EsxA's inhibitors for combating methicillin-resistant Staphylococcus aureus (MRSA)
Investigator(s):	Sze KH, Kao RYT
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2014

Project Title:	System Biology investigation on virulence factors of methicillin-resistant Staphylococcus aureus (MRSA)
Investigator(s):	Sze KH, Yuen KY, Kao RYT
Department:	Microbiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2015

Project Title:	Host target characterizations for early secreted virulence factors ESAT6/CFP10 of Mycobacterium tuberculosis and structure-based screening of ESAT6/CFP10 's inhibitors for combating multi-drug resistant tuberculosis (MDR-TB)
Investigator(s):	Sze KH, Kao RYT
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2015

Project Title:	XXVIIth International Conference on Magnetic Resonance in Biological Systems; Mp1p-LBD2 of Talaromyces marneffei captures proinflammatory arachidonic acid: a novel virulence mechanism of pathogenic fungi
Investigator(s):	Sze KH
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2016
Completion Date:	08/2016

Project Title:	Structure and function Investigation of pro-inflammatory lipid binding virulence factor of pathogenic Talaromyces marneffei
Investigator(s):	Sze KH, Yuen KY, Kao RYT
Department:	Microbiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	02/2017

List of Research Outputs

Chan C.M., Chu H., Zhang J., Leung L.H., Sze K.H., Kao R.Y.T., Chik K.K.H., To K.K.W., Chan J.F.W., Chen H., Jin D., Liu L. and Yuen K.Y., Hemagglutinin of influenza A virus binds specifically to cell surface nucleolin and plays a role in virus internalization, Virology. 2016, 494: 78-88.

Sze K.H., Lam W.H., Zhang H., Ke Y., Tse M.K., Woo P.C.Y., Lau S.K.P., Lau C.Y., Cai J., Tung E.T., Lo R.K., Xu S., Kao R.Y.T., Hao Q. and Yuen K.Y., Talaromyces marneffei Mp1p Is a Virulence Factor that Binds and Sequesters a Key Proinflammatory Lipid to Dampen Host Innate Immune Response, Cell Chemical Biology. 2017, 24: 182-194.

Woo P.C.Y., Lau S.K.P., Lau C.Y., Tung T.K., Chong T.K., Yang F., Zhang H., Lo K.C., Cai J., Au Yeung K.H.R., Ng W.F., Tse H., Wong S.S.Y., Xu S., Lam W.H., Tse M.K., Sze K.H., Kao R.Y.T., Reiner N.E., Hao Q. and Yuen K.Y., Mp1p Is a Virulence Factor in Talaromyces (Penicillium) marneffei, PLOS Neglected Tropical Diseases. 2016, 10: e0004907.

ZHANG B., Cai J., Yu B., HUA Y., Lau C.Y., Kao R.Y.T., Sze K.H., Yuen K.Y. and Huang J., A DNA vaccine targeting TcdA and TcdB induces protective immunity against Clostridium difficile, BMC Infectious Diseases. 2016, 16.

Researcher : TANG Y

List of Research Outputs

TANG Y., Teng L.L., Cheung C.L., Ngan A.H., Huang Y., Wong S.S.Y., Yip E.K., Ng K.H., Que T.L., Lau S.K.P. and Woo P.C.Y., Tsukamurellaserpentis sp. nov., isolated from the oral cavity of Chinese cobras (Naja atra), International Journal of Systematic and Evolutionary Microbiology. 2016, 66: 3329-3336.

Teng L.L., Tang Y., Huang Y., Guo F.B., Wei W., Chen J.H.H.K., Wong S.S.Y., Lau S.K.P. and Woo P.C.Y., Phylogenomic Analyses and Reclassification of Species within the Genus Tsukamurella: Insights to Species Definition in the Post-genomic Era, Frontiers in Microbiology. 2016, 7.

Teng L.L., Tang Y., Chiu T.H., Ngan A.H., Ngai C., Wong S.S.Y., Lau S.K.P. and Woo P.C.Y., The groEL gene is a promising target for species-level identification of Tsukamurella, Journal of Clinical Microbiology. American Society for Microbiology, 2017, 55: 649-653.

Researcher : TONG S

List of Research Outputs

Chen H., Verhoeven R., TONG S. and Mok B.W.Y., Epstein-Barr virus BART noncoding RNAs modulate host gene expression for virus latency leading to oncogenesis in epithelial cells, AACR annual meeting . 2017.

Verhoeven R.J.A., TONG S., Zhang G.H., Zong J.F., Chen Y.X., Jin D., Chen M.R., Pan J.J. and Chen H., NF-κB Signaling Regulates Expression of Epstein-Barr Virus BART MicroRNAs and Long Noncoding RNAs in Nasopharyngeal Carcinoma, Journal of Virology. USA, AMER SOC MICROBIOLOGY, 2016, 90: 6475-6488.

Researcher : TSANG CC

List of Research Outputs

Lau S.K.P., Tsang C.C. and Woo P.C.Y., Talaromyces marneffei genomic, transcriptomic, proteomic and metabolomic studies reveal mechanisms for environmental adaptations and virulence, Toxins. 2017, 9: 192.

TSANG C.C., Chan J.F.W., Pong W.M., Chen H.K.J., Ngan A.H.Y., Cheung M., Lai C.K.C., Tsang D.N.C., Lau S.K.P. and Woo P.C.Y., Cutaneous hyalohyphomycosis due to Parengyodontium album gen. et comb. nov. , Medical Mycology. 2016, 54: 699-713.

TSANG C.C., Xiong L., Poon W.S.R., Chen H.K.J., Leung K.W., Lam J.Y.W., Wu K.L.A., Chan J.F.W., Lau S.K.P. and Woo P.C.Y., Gordonia hongkongensis sp. nov., isolated from blood culture and peritoneal dialysis effluent of patients in Hong Kong, International Journal of Systematic and Evolutionary Microbiology. 2016, 66: 3942-3950.

Tam W.T., TSANG C.C., Lau S.K.P. and Woo P.C.Y., Comparative mitogenomic and phylogenetic characterization on the complete mitogenomes of Talaromyces (Penicillium) marneffei , Mitochondrial DNA Part B. 2016, 1: 941-942.

Woo P.C.Y., Lau S.K.P., Tsang C.C., Lau C.Y., Wong P.C., Chow W.N., Fong J.Y.H. and Yuen K.Y., Coronavirus HKU15 in respiratory tract of pigs and first discovery of coronavirus quasispecies in 5′-untranslated region, Emerging Microbes & Infections. 2017, 6: e53.

Researcher : TSANG GWT

List of Research Outputs

Chan J.F.W., Yip C.Y., Tee K.M., Zhu Z., Tsang O.L., Chik K.K.H., TSANG G.W.T., Chan C.S., Poon K.M., Sridhar S., Yin F., Hung F.N.I., Chau S.K.Y., Zhang J., Chan K.H. and Yuen K.Y., Improved detection of Zika virus RNA in human and animal specimens by a novel, highly sensitive and specific real-time RT-PCR assay targeting the 5′-untranslated region of Zika virus, Tropical Medicine & International Health. 2017, 22: 594-603.

Yip C.Y., Tee K.M., ZHU Z., TSANG O.L., CHIK K.K.H., TSANG G.W.T., Chan C.S., Poon K.M., Sridhar S., Yin F., Hung F.N.I., Chau S.K.Y., Zhang J., Chan K.H., Yuen K.Y. and Chan J.F.W., Improved detection of Zika virus RNA in human and animal specimens by a novel, highly sensitive and specific real-time RT-PCR assay targeting the 5'-untranslated region of Zika virus, 33rd ASM Clinical Virology Symposium. 2017.

Researcher : TSANG OL

List of Research Outputs

Chan J.F.W., Zhang J., Chan C.S., Yip C.Y., Mak W.N., Zhu H., Poon K.M., Tee K.M., Zhu Z., Cai J., Tsang O.L., Chik K.K.H., Yin F., Chan K.H., Kok K.H., Jin D., Au Yeung K.H.R. and Yuen K.Y., Characterization of a novel mouse model for Zika virus infection using dexamethasone-immunosuppressed mice, First International Conference on Zika Virus. 2017.

Chan J.F.W., Chan K.H., Yuan S., CHIK K.K.H., ZHU Z., Tee K.M., TSANG O.L., Yip C.Y., Poon K.M., Chan C.S., Mak W.N., Zhang J. and Yuen K.Y., Development of an in ovo system for evaluation of antivirals against Zika virus, 30th International Conference on Antiviral Research (ICAR). 2017.

Chan J.F.W., Yip C.Y., Tsang O.L., Tee K.M., Cai J., Chik K.K.H., Zhu Z., Chan C.S., CHOI K.Y., Sridhar S., Zhang J., Lu G., Chiu K., Lo A.C.Y., Tsao G.S.W., Kok K.H., Jin D., Chan K.H. and Yuen K.Y., Differential cell line susceptibility to the emerging Zika virus: implications for disease pathogenesis, non-vector-borne human transmission and animal reservoirs, Emerging Microbes & Infections. 2016, 5: e93.

Chan J.F.W., Yip C.Y., Tee K.M., Zhu Z., Tsang O.L., Chik K.K.H., TSANG G.W.T., Chan C.S., Poon K.M., Sridhar S., Yin F., Hung F.N.I., Chau S.K.Y., Zhang J., Chan K.H. and Yuen K.Y., Improved detection of Zika virus RNA in human and animal specimens by a novel, highly sensitive and specific real-time RT-PCR assay targeting the 5′-untranslated region of Zika virus, Tropical Medicine & International Health. 2017, 22: 594-603.

Chan J.F.W., CHIK K.K.H., Yuan S., Yip C.Y., ZHU Z., Tee K.M., TSANG O.L., Chan C.S., Poon K.M., Lu G., Zhang J., Lai K.K., Chan K.H., Kao R.Y.T. and Yuen K.Y., Novel antiviral activity and mechanism of bromocriptine as a Zika virus NS2B-NS3 protease inhibitor, Antiviral Research. 2017, 141: 29-37.

Chan J.F.W., Zhang J., Chan C.S., Yip C.Y., Mak W.N., Zhu H., Poon K.M., Tee K.M., Zhu Z., Cai J., Tsang O.L., Chik K.K.H., Yin F., Chan K.H., Kok K.H., Jin D., Au Yeung K.H.R. and Yuen K.Y., Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons, EBioMedicine. 2016, 14: 112-122.

Yip C.Y., Tee K.M., Zhu Z., Chik K.K.H., Tsang O.L., Poon K.M., Chan C.S., Zhang J., Chan K.H., Yuen K.Y. and Chan J.F.W., Development and evaluation of a novel real-time RT-PCR assay targeting the envelope gene of the African and Asian/American lineages of the emerging Zika virus, 3rd Microbiology Asia Congress. 2016.

Yip C.Y., Tee K.M., ZHU Z., TSANG O.L., CHIK K.K.H., TSANG G.W.T., Chan C.S., Poon K.M., Sridhar S., Yin F., Hung F.N.I., Chau S.K.Y., Zhang J., Chan K.H., Yuen K.Y. and Chan J.F.W., Improved detection of Zika virus RNA in human and animal specimens by a novel, highly sensitive and specific real-time RT-PCR assay targeting the 5'-untranslated region of Zika virus, 33rd ASM Clinical Virology Symposium. 2017.

Researcher : Tai JWM

List of Research Outputs

Cheng C.C.V., Wong S.C., Wong I.W.Y., Chau P.H., So S.Y.C., Wong C.Y.S., Chen H.K.J., Lee W.M., Tai J.W.M., Chau C.H., Lo W.K. and Yuen K.Y., The challenge of patient empowerment in hand hygiene promotion in health care facilities in Hong Kong, American Journal of Infection Control. 2017, 45: 562-565.

Researcher : Tam WT

List of Research Outputs

Tam W.T., TSANG C.C., Lau S.K.P. and Woo P.C.Y., Comparative mitogenomic and phylogenetic characterization on the complete mitogenomes of Talaromyces (Penicillium) marneffei , Mitochondrial DNA Part B. 2016, 1: 941-942.

Researcher : Tan Z

Project Title:	Role of Δ42PD1/TLR4 interaction in human hepatocellular carcinoma and its blockade as a novel immunotherapy strategy
Investigator(s):	Tan Z, Chen Z
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2016

Project Title:	Combination of dendritic cell-based vaccination and immune checkpoint blockade for malignant mesothelioma immunotherapy
Investigator(s):	Tan Z, Chen Z
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2017

Researcher : Tang SF

List of Research Outputs

Chan J.F.W., Choi G.K.Y., Leung S.S.M., Tee K.M., Tang S.F., Hung F.N.I. and Yuen K.Y., Epidemiological and clinical characteristics of patients with anti-interferon-gamma autoantibodies associated with opportunistic infections in Hong Kong, European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 2017.

Chan J.F.W., Choi G.K.Y., Leung S.S.M., Tee K.M., Tang S.F., Hung F.N.I. and Yuen K.Y., Epidemiology, Seroprevalence, and Clinical Manifestations of Immunodeficiency due to Autoantibody Against Interferon Gamma in Hong Kong, Health Research Symposium 2017 (Health and Medical Research Fund). 2017.

Chen H.K.J., Lam H.Y., Yip C.Y., Wong S.C.Y., Chan J.F.W., Ma E.S., Cheng V.C.C., Tang S.F. and Yuen K.Y., Clinical Evaluation of the New High-Throughput Luminex NxTAG Respiratory Pathogen Panel Assay for Multiplex Respiratory Pathogen Detection, Journal of Clinical Microbiology. 2016, 54: 1820-1825.

Researcher : Tang Y

List of Research Outputs

Researcher : Tee KM

List of Research Outputs

Chan J.F.W., Zhang J., Chan C.S., Yip C.Y., Mak W.N., Zhu H., Poon K.M., Tee K.M., Zhu Z., Cai J., Tsang O.L., Chik K.K.H., Yin F., Chan K.H., Kok K.H., Jin D., Au Yeung K.H.R. and Yuen K.Y., Characterization of a novel mouse model for Zika virus infection using dexamethasone-immunosuppressed mice, First International Conference on Zika Virus. 2017.

Chan J.F.W., Chan K.H., Yuan S., CHIK K.K.H., ZHU Z., Tee K.M., TSANG O.L., Yip C.Y., Poon K.M., Chan C.S., Mak W.N., Zhang J. and Yuen K.Y., Development of an in ovo system for evaluation of antivirals against Zika virus, 30th International Conference on Antiviral Research (ICAR). 2017.

Chan J.F.W., Yip C.Y., Tsang O.L., Tee K.M., Cai J., Chik K.K.H., Zhu Z., Chan C.S., CHOI K.Y., Sridhar S., Zhang J., Lu G., Chiu K., Lo A.C.Y., Tsao G.S.W., Kok K.H., Jin D., Chan K.H. and Yuen K.Y., Differential cell line susceptibility to the emerging Zika virus: implications for disease pathogenesis, non-vector-borne human transmission and animal reservoirs, Emerging Microbes & Infections. 2016, 5: e93.

Chan J.F.W., Choi G.K.Y., Leung S.S.M., Tee K.M., Tang S.F., Hung F.N.I. and Yuen K.Y., Epidemiological and clinical characteristics of patients with anti-interferon-gamma autoantibodies associated with opportunistic infections in Hong Kong, European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 2017.

Chan J.F.W., Choi G.K.Y., Leung S.S.M., Tee K.M., Tang S.F., Hung F.N.I. and Yuen K.Y., Epidemiology, Seroprevalence, and Clinical Manifestations of Immunodeficiency due to Autoantibody Against Interferon Gamma in Hong Kong, Health Research Symposium 2017 (Health and Medical Research Fund). 2017.

Chan J.F.W., Tee K.M., CHOI K.Y., Zhu Z., Poon W.S.R., Ng K.T.P., Chan K.H., Hung F.N.I., Man K. and Yuen K.Y., First detection and complete genome sequence of a phylogenetically distinct human polyomavirus 6 highly prevalent in human bile samples, Journal of Infection. 2017, 74: 50-59.

Chan J.F.W., Yip C.Y., Tee K.M., Zhu Z., Tsang O.L., Chik K.K.H., TSANG G.W.T., Chan C.S., Poon K.M., Sridhar S., Yin F., Hung F.N.I., Chau S.K.Y., Zhang J., Chan K.H. and Yuen K.Y., Improved detection of Zika virus RNA in human and animal specimens by a novel, highly sensitive and specific real-time RT-PCR assay targeting the 5′-untranslated region of Zika virus, Tropical Medicine & International Health. 2017, 22: 594-603.

Chan J.F.W., CHIK K.K.H., Yuan S., Yip C.Y., ZHU Z., Tee K.M., TSANG O.L., Chan C.S., Poon K.M., Lu G., Zhang J., Lai K.K., Chan K.H., Kao R.Y.T. and Yuen K.Y., Novel antiviral activity and mechanism of bromocriptine as a Zika virus NS2B-NS3 protease inhibitor, Antiviral Research. 2017, 141: 29-37.

Chan J.F.W., Zhang J., Chan C.S., Yip C.Y., Mak W.N., Zhu H., Poon K.M., Tee K.M., Zhu Z., Cai J., Tsang O.L., Chik K.K.H., Yin F., Chan K.H., Kok K.H., Jin D., Au Yeung K.H.R. and Yuen K.Y., Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons, EBioMedicine. 2016, 14: 112-122.

Yip C.Y., Tee K.M., Zhu Z., Chik K.K.H., Tsang O.L., Poon K.M., Chan C.S., Zhang J., Chan K.H., Yuen K.Y. and Chan J.F.W., Development and evaluation of a novel real-time RT-PCR assay targeting the envelope gene of the African and Asian/American lineages of the emerging Zika virus, 3rd Microbiology Asia Congress. 2016.

Yip C.Y., Tee K.M., ZHU Z., TSANG O.L., CHIK K.K.H., TSANG G.W.T., Chan C.S., Poon K.M., Sridhar S., Yin F., Hung F.N.I., Chau S.K.Y., Zhang J., Chan K.H., Yuen K.Y. and Chan J.F.W., Improved detection of Zika virus RNA in human and animal specimens by a novel, highly sensitive and specific real-time RT-PCR assay targeting the 5'-untranslated region of Zika virus, 33rd ASM Clinical Virology Symposium. 2017.

Researcher : Teng LL

Project Title:	Usefulness of full sequence and 5' end 527-bp 16S ribosomal RNA gene sequencing for identification of medically important aerobic Gram-positive cocci
Investigator(s):	Teng LL, Woo PCY, Lau SKP, Yuen KY
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	09/2006

List of Research Outputs

Sridhar S., Teng L.L., Chiu T.H., Lau S.K.P. and Woo P.C.Y., Hepatitis E Virus Genotypes and Evolution: Emergence of Camel Hepatitis E Variants, International Journal of Molecular Sciences. 2017, 18: 869.

TANG Y., Teng L.L., Cheung C.L., Ngan A.H., Huang Y., Wong S.S.Y., Yip E.K., Ng K.H., Que T.L., Lau S.K.P. and Woo P.C.Y., Tsukamurellaserpentis sp. nov., isolated from the oral cavity of Chinese cobras (Naja atra), International Journal of Systematic and Evolutionary Microbiology. 2016, 66: 3329-3336.

Teng L.L., Tang Y., Huang Y., Guo F.B., Wei W., Chen J.H.H.K., Wong S.S.Y., Lau S.K.P. and Woo P.C.Y., Phylogenomic Analyses and Reclassification of Species within the Genus Tsukamurella: Insights to Species Definition in the Post-genomic Era, Frontiers in Microbiology. 2016, 7.

Teng L.L., Tang Y., Chiu T.H., Ngan A.H., Ngai C., Wong S.S.Y., Lau S.K.P. and Woo P.C.Y., The groEL gene is a promising target for species-level identification of Tsukamurella, Journal of Clinical Microbiology. American Society for Microbiology, 2017, 55: 649-653.

Wang J., Teng L.L., Zhao D., Ge P., Li B., Woo P.C.Y. and Liu C.H., The ubiquitin ligase TRIM27 functions as a host restriction factor antagonized by Mycobacterium tuberculosis PtpA during mycobacterial infection, Scientific reports. 2016, 6: 34827.

Woo P.C.Y., Teng L.L., BAI R., Wong Y.P., Martelli P., Hui S.W., Tsang K.L., Lau C.Y., Ahmed S.S., Yip C.Y., CHOI K.Y., Li K.S.M., Lam S.F., Lau S.K.P. and Yuen K.Y., High Diversity of Genogroup I Picobirnaviruses in Mammals, Frontier in microbiology. 2016, 7: 1886.

Woo P.C.Y., Lau S.K.P., Teng L.L., Cao K.Y., Wernery U., Schountz T., Chiu T.H., Tsang K.L., Wong P.C., Wong Y.M. and Yuen K.Y., New Hepatitis E Virus Genotype in Bactrian Camels, Xinjiang, China, 2013, Emerging Infectious Diseases. 2016, 22: 2219-2221.

Xiong L., Yang Y., Ye Y.N., Teng L.L., Chan E., Watt R.M., Guo F.B., Lau S.K.P. and Woo P.C.Y., Laribacter hongkongensis anaerobic adaptation mediated by arginine metabolism is controlled by the cooperation of FNR and ArgR, Environmental Microbiology. 2017, 19: 1266-1280.

Researcher : To KKW

Project Title:	Rapid detection of macrolide resistance amony Mycoplasma pneumoniae in Queen Mary Hospital
Investigator(s):	To KKW, Ho PL, Chan KH, Hung FNI, Chiu SSS
Department:	Microbiology
Source(s) of Funding:	Queen Mary Hospital Charitable Trust - Training and Research Assistance Scheme
Start Date:	07/2011

Project Title:	Serological study of H7N9, H5N1 and H9N2 influenza among animal handlers
Investigator(s):	To KKW, Hung FNI, Yuen KY, Chan JFW
Department:	Microbiology
Source(s) of Funding:	Centre for Health Protection
Start Date:	09/2013

Project Title:	Identification of innate immune defect predisposing to severe influenza in a Chinese population
Investigator(s):	To KKW, Zhou J, Song Y, Hung FNI, Yuen KY
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	09/2013
Completion Date:	09/2016

Project Title:	Serological study of H7N9, H5N1 and H9N2 influenza among animal handlers (CHP-PH-11)
Investigator(s):	To KKW
Department:	Microbiology
Source(s) of Funding:	Commissioned Project: Health and Medical Research Fund
Start Date:	10/2013

Project Title:	Viral Immunity: Mechanisms and Consequences (B4) ; Does antiviral substance in saliva affect culture positivity?
Investigator(s):	To KKW
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	02/2017
Completion Date:	02/2017

List of Research Outputs

Chan C.M., Chu H., Zhang J., Leung L.H., Sze K.H., Kao R.Y.T., Chik K.K.H., To K.K.W., Chan J.F.W., Chen H., Jin D., Liu L. and Yuen K.Y., Hemagglutinin of influenza A virus binds specifically to cell surface nucleolin and plays a role in virus internalization, Virology. 2016, 494: 78-88.

Fang C.X., Wong T.M., To K.K.W., Wong S.S.Y., Lau T.W. and Leung F.K.L., Infection after fracture osteosynthesis – Part II, Journal of Orthopaedic Surgery. 2017, 25: 230949901769271.

Fang C.X., Wong T.M., Lau T.W., To K.K.W., Wong S.S.Y. and Leung F.K.L., Infection after fracture osteosynthesis – Part I, Journal of Orthopaedic Surgery. 2017, 25: 230949901769271.

Hung F.N.I., To K.K.W., Chan J.F.W., Cheng C.C.V., Liu S.H.K., Tam A., Chan T.C.I., Zhang J., Li P.C.K., Wong T.L., ZHANG R., Cheung M.K.S., Leung W., Lau J.Y., Fok M., Chen H., Chan K.H. and Yuen K.Y., Efficacy of Clarithromycin-Naproxen-Oseltamivir Combination in the Treatment of Patients Hospitalized for Influenza A(H3N2) Infection: an open-label, randomized controlled, phase 2b/3 trial., Chest. 2017, 151: 1069-1080.

Hung F.N.I., Zhang J., To K.K.W., Chan J.F.W., ZHU H., ZHANG R., Chan T.C.I., Chan K.H. and Yuen K.Y., Unexpectedly Higher Morbidity and Mortality of Hospitalized Elderly Patients Associated with Rhinovirus Compared with Influenza Virus Respiratory Tract Infection, International Journal of Molecular Sciences. 2017, 18: 259.

Lee C.Y., To K.K.W., Zhu H., Chu H., Mak W.N., Zhang J. and Yuen K.Y., Avian influenza virus A H7N9 infects multiple mononuclear cell types in peripheral blood and induces dysregulated cytokine responses and apoptosis in infected monocytes, Journal of General Virology. 2017, 98: 922-934.

To K.K.W., Lu L., Yip C.Y., Poon W.S.R., Fung A.M.Y., Cheng A., Lui D.H.K., Ho T.Y., Hung F.N.I., Chan K.H. and Yuen K.Y., Additional molecular testing of saliva specimens improves the detection of respiratory viruses, Emerging Microbes & Infections. 2017, 6: e49.

To K.K.W., Associate Editor, BMC Infectious Diseases. 2016.

To K.K.W., Difficulties in treating (managing patients with) antibiotic-resistant organisms, International Conference on Global Food Safety and Antimicrobial Resistance. 2016.

To K.K.W., Chan W.M., Li K.S.M., Lam S.F., Chen Z., Tse H., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., High prevalence of four novel astrovirus genotype species identified from rodents in China, Journal of General Virology. 2017, 98: 1004-1015.

To K.K.W., History taking, physical examination, investigation and diagnosis in infectious disease, Post-registration Certificate Course in Infectious Disease Nursing 2017. 2017.

To K.K.W., Lu L., Hung F.N.I. and Yuen K.Y., Host response of rhinovirus infection among hospitalized adult patients, American Society for Virology 36th Annual Meeting. 2017.

Researcher : To WCS

Project Title:	Pharmacogenomic and molecular epidemiological study of HIV/AIDS patients co-infected with Hepatitis C virus (HCV)
Investigator(s):	To WCS, Yam WC
Department:	Microbiology
Source(s) of Funding:	Council for the AIDS Trust Fund - General Award
Start Date:	10/2015

Project Title:	Latent proviral DNA reservoir as a target for HIV-1 genotypic resistance and tropism analyses amoung HIV-1 patients with viremia or suppressed viral load
Investigator(s):	To WCS, Yam WC
Department:	Microbiology
Source(s) of Funding:	Council for the AIDS Trust Fund - General Award
Start Date:	10/2016

Researcher : Tong MK

List of Research Outputs

Ho P.L., Ho L.Y., Yau C.Y., Tong M.K. and Chow K.H., A Novel Selective Medium for Isolation of Bacteroides fragilis from Clinical Specimens, Journal of Clinical Microbiology. 2017, 55: 384-390.

Researcher : Tsang CC

List of Research Outputs

Researcher : Tsang DNC

List of Research Outputs

TSANG C.C., Chan J.F.W., Pong W.M., Chen H.K.J., Ngan A.H.Y., Cheung M., Lai C.K.C., Tsang D.N.C., Lau S.K.P. and Woo P.C.Y., Cutaneous hyalohyphomycosis due to Parengyodontium album gen. et comb. nov. , Medical Mycology. 2016, 54: 699-713.

Researcher : Tsang KL

List of Research Outputs

Lau S.K.P., Wernery R., Wong Y.M., Joseph S., Tsang K.L., Patteril N.A., Elizabeth S.K., Chan K.H., Muhammed R., Kinne J., Yuen K.Y., Wernery U. and Woo P.C.Y., Polyphyletic origin of MERS coronaviruses and isolation of a novel clade A strain from dromedary camels in the United Arab Emirates, Emerging Microbes and Infections. 2016, 5: e128.

Woo P.C.Y., Teng L.L., BAI R., Wong Y.P., Martelli P., Hui S.W., Tsang K.L., Lau C.Y., Ahmed S.S., Yip C.Y., CHOI K.Y., Li K.S.M., Lam S.F., Lau S.K.P. and Yuen K.Y., High Diversity of Genogroup I Picobirnaviruses in Mammals, Frontier in microbiology. 2016, 7: 1886.

Woo P.C.Y., Lau S.K.P., Teng L.L., Cao K.Y., Wernery U., Schountz T., Chiu T.H., Tsang K.L., Wong P.C., Wong Y.M. and Yuen K.Y., New Hepatitis E Virus Genotype in Bactrian Camels, Xinjiang, China, 2013, Emerging Infectious Diseases. 2016, 22: 2219-2221.

Researcher : Tsang OL

List of Research Outputs

Chan J.F.W., Zhang J., Chan C.S., Yip C.Y., Mak W.N., Zhu H., Poon K.M., Tee K.M., Zhu Z., Cai J., Tsang O.L., Chik K.K.H., Yin F., Chan K.H., Kok K.H., Jin D., Au Yeung K.H.R. and Yuen K.Y., Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons, EBioMedicine. 2016, 14: 112-122.

Researcher : Tse H

Project Title:	Molecular characterization of antibiotic resistance in Staphylococcus lugdunensis isolates
Investigator(s):	Tse H, Ho PL
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2014
Completion Date:	11/2016

List of Research Outputs

To K.K.W., Chan W.M., Li K.S.M., Lam S.F., Chen Z., Tse H., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., High prevalence of four novel astrovirus genotype species identified from rodents in China, Journal of General Virology. 2017, 98: 1004-1015.

Wong S.C.Y., Tse H., Chen H.K.J., Cheng V.C.C., Ho P.L. and Yuen K.Y., Colistin-Resistant Enterobacteriaceae Carrying the mcr-1 Gene among Patients in Hong Kong , Emerging Infectious Diseases. 2016, 22: 1667-1669.

Woo P.C.Y., Lau S.K.P., Lau C.Y., Tung T.K., Chong T.K., Yang F., Zhang H., Lo K.C., Cai J., Au Yeung K.H.R., Ng W.F., Tse H., Wong S.S.Y., Xu S., Lam W.H., Tse M.K., Sze K.H., Kao R.Y.T., Reiner N.E., Hao Q. and Yuen K.Y., Mp1p Is a Virulence Factor in Talaromyces (Penicillium) marneffei, PLOS Neglected Tropical Diseases. 2016, 10: e0004907.

Researcher : Tse MK

List of Research Outputs

Sze K.H., Lam W.H., Zhang H., Ke Y., Tse M.K., Woo P.C.Y., Lau S.K.P., Lau C.Y., Cai J., Tung E.T., Lo R.K., Xu S., Kao R.Y.T., Hao Q. and Yuen K.Y., Talaromyces marneffei Mp1p Is a Virulence Factor that Binds and Sequesters a Key Proinflammatory Lipid to Dampen Host Innate Immune Response, Cell Chemical Biology. 2017, 24: 182-194.

Woo P.C.Y., Lau S.K.P., Lau C.Y., Tung T.K., Chong T.K., Yang F., Zhang H., Lo K.C., Cai J., Au Yeung K.H.R., Ng W.F., Tse H., Wong S.S.Y., Xu S., Lam W.H., Tse M.K., Sze K.H., Kao R.Y.T., Reiner N.E., Hao Q. and Yuen K.Y., Mp1p Is a Virulence Factor in Talaromyces (Penicillium) marneffei, PLOS Neglected Tropical Diseases. 2016, 10: e0004907.

Researcher : Tsoi HW

List of Research Outputs

Woo P.C.Y., Lau S.K.P., Choi G.K.Y., Hunag Y., Sivakumar S., Tsoi H.W., Yip C.C., Jose S.V., BAI R., Wong Y.M., Joesph M., Li T., Wernery U. and Yuen K.Y., Molecular epidemiology of canine picornavirus in Hong Kong and Dubai and proposal of a novel genus in Picornaviridae., Infect Genet Evol.. 2016, 41: 191-200.

Woo P.C.Y., Lau S.K.P., Tsoi H.W., Patteril N.G., Yeung C., Joseph S., Wong Y.M., Muhammed R., Chow W.N., Wernery U. and Yuen K.Y., Two novel dromedary camel bocaparvoviruses from dromedaries in the Middle East with unique genomic features, The Journal of General Virology. 2017, 98: 1349-1359.

Researcher : Tung TK

List of Research Outputs

Woo P.C.Y., Lau S.K.P., Lau C.Y., Tung T.K., Chong T.K., Yang F., Zhang H., Lo K.C., Cai J., Au Yeung K.H.R., Ng W.F., Tse H., Wong S.S.Y., Xu S., Lam W.H., Tse M.K., Sze K.H., Kao R.Y.T., Reiner N.E., Hao Q. and Yuen K.Y., Mp1p Is a Virulence Factor in Talaromyces (Penicillium) marneffei, PLOS Neglected Tropical Diseases. 2016, 10: e0004907.

Researcher : Verhoeven RJA

Project Title:	17th International Symposium on EBV and Associated Diseases; BamHI-A rightward transcripts function as nuclear long non-coding RNA and modulate host gene expression by interacting with CBP
Investigator(s):	Verhoeven RJA
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2016
Completion Date:	08/2016

List of Research Outputs

Verhoeven R.J.A., TONG S., Zhang G.H., Zong J.F., Chen Y.X., Jin D., Chen M.R., Pan J.J. and Chen H., NF-κB Signaling Regulates Expression of Epstein-Barr Virus BART MicroRNAs and Long Noncoding RNAs in Nasopharyngeal Carcinoma, Journal of Virology. USA, AMER SOC MICROBIOLOGY, 2016, 90: 6475-6488.

Researcher : WANG X

List of Research Outputs

Jiang L., YAN Q., WANG X., Shi C. and Guan X., Characterization of the genes specifically expressed in liver progenitor cells of in vitro hepatic differentiation model, 38th Annual Lorne Genome Conference; Feb 12-14, 2017, Lorne, Australia. 2017.

WANG X., Jiang L., Shi C., Chen H. and Guan X., Characterization of a stemness-related gene RALYL in the development and progression of hepatocellular carcinoma, 3rd EACR Conference on Cancer Genomics; June 25-28, 2017, Cambridge, UK. 2017.

Researcher : WANG Y

List of Research Outputs

Chan C.M., Chu H., Wang Y., Wong H.Y.B., Zhao X., Zhou J., Yang D., Leung A.S.P., Chan J.F.W., Yeung M.L., Yan J., Lu G., Gao G.F. and Yuen K.Y., Carcinoembryonic Antigen-related Cell Adhesion Molecule 5 (CEACAM5) Is an Important Surface Attachment Factor Facilitating the Entry of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV), Journal of Virology. 2016, JVI.01133-16.

Gao P., Wang Y., Villanueva I., Ho P.L., Davies J. and Kao R.Y.T., Construction of a Multiplex Promoter Reporter Platform to Monitor Staphylococcus aureus Virulence Gene Expression and the Identification of Usnic Acid as a Potent Suppressor of psm Gene Expression, In: Dongsheng Zhou, Frontiers in Microbiology. 2016, 7: 1-14.

Gao P., Wang Y., Villanueva I.V.Á.N., Ho P.L., Davies J.U.L.I.A.N. and Kao R.Y.T., Multiplex Promoter Reporter Platform to Monitor Staphylococcus aureus Virulence Gene Expression , 2016 world life science conference. 2016.

WANG Y., Lo W.U., Lai R.W., Tsw C.W., Lee R.A., Luk W.K., Cheng C.C.V., Que T.L., Chow K.H. and Ho P.L., IncN ST7 epidemic plasmid carrying bla IMP-4 in Enterobacteriaceae isolates with epidemiological links to multiple geographical areas in China , Journal of Antimicrobial Chemotherapy. 2017, 72: 99-103.

WANG Y., Lo W.U., Yau C.Y., Chow K.H. and Ho P.L., Impact of intraobserver and interobserver variation on performance of the CLSI Carba NP assay for carbapenemase detection in Enterobacteriaceae, Journal of Global Antimicrobial Resistance. 2017, 9: 19-20.

Researcher : WU X

List of Research Outputs

WU X., Liu L., Cheung K.W., Wang H., Lu X., Cheung K.L.A., LIU W., Huang X., Li Y., Chen Z., CHEN S.M.Y., Zhang T., Wu H. and Chen Z., Brain Invasion by CD4+ T Cells Infected with a Transmitted/Founder HIV-1BJZS7 During Acute Stage in Humanized Mice, Journal of Neuroimmune Pharmacology. 2016, 11: 572-583.

Researcher : Wang H

List of Research Outputs

Liu L., Wang H. and Chen Z., Anti-spike IgG exacerbates lung injury by skewing monocyte-macrophage responses during SARS-CoV infection, IMMUNOLOGY 2017.

Liu L., Wei Q., Nishiura K., PENG J., Wang H., Midkiff C., Alvarez X., Qin C., Lackner A. and Chen Z., Spatiotemporal interplay of severe acute respiratory syndrome coronavirus and respiratory mucosal cells drives viral dissemination in rhesus macaques, Mucosal Immunology. 2016, 9: 1089-1101.

Researcher : Wang P

List of Research Outputs

HUANG X., ZHENG M., Wang P., Mok B.W.Y., LIU S., Lau S.Y., CHEN P., Liu Y., LIU H., CHEN Y., Song W., Yuen K.Y. and Chen H., An NS-segment exonic splicing enhancer regulates influenza A virus replication in mammalian cells, Nature Communications. 2017, 8: 14751.

Zheng M., Wang P., Lau S.Y., HUANG X., Mok B.W.Y., LIU S., LIU H., Liu Y. and Chen H., Characterization of mutations associated with cold adapted properties in DelNS1 influenza viruses; potential for new live attenuated influenza vaccine development , Options IX for The Control of Influenza, Chicago, USA, 24-28 Aug, 2016.

Researcher : Wang Y

List of Research Outputs

Researcher : Wang Y

List of Research Outputs

Researcher : Wen LR

List of Research Outputs

Ye Z., Yuan S., Poon K.M., Wen L.R., Yang D., Sun Z., Li C., Hu M., Shuai H., Zhou J., Zhang M., Zheng B., Chu H. and Yuen K.Y., Antibody-Dependent Cell-Mediated Cytotoxicity Epitopes on the Hemagglutinin Head Region of Pandemic H1N1 Influenza Virus Play Detrimental Roles in H1N1-Infected Mice, Frontiers in Immunology. Frontiers, 2017, 8: 317.

Zhao H., Chu H., Zhao X., SHUAI H., Wong H.Y.B., Wen L.R., Yuan S., Zheng B., Zhou J. and Yuen K.Y., Novel residues in the PA protein of avian influenza H7N7 virus affect virulence in mammalian hosts, Virology. 2016, 498: 1-8.

Researcher : Wong CYS

List of Research Outputs

Cheng C.C.V., Chen H.K.J., So S.Y.C., Wong C.Y.S., Chau P.H., Wong M.W.L., Ching H.C.R., Ng L.M.M., Lee W.M., Hung F.N.I., Ho P.L. and Yuen K.Y., A novel risk factor associated with colonization by Carbapenemase-Producing Enterobacteriaceae: Use of Proton Pump Inhibitors in addition to Antimicrobial Treatment, Infection Control & Hospital Epidemiology. 2016, 37: 1418-1425.

Cheng C.C.V., Wong S.C., Wong I.W.Y., Chau P.H., So S.Y.C., Wong C.Y.S., Chen H.K.J., Lee W.M., Tai J.W.M., Chau C.H., Lo W.K. and Yuen K.Y., The challenge of patient empowerment in hand hygiene promotion in health care facilities in Hong Kong, American Journal of Infection Control. 2017, 45: 562-565.

Researcher : Wong HYB

List of Research Outputs

Chan C.M., Chu H., Wang Y., Wong H.Y.B., Zhao X., Zhou J., Yang D., Leung A.S.P., Chan J.F.W., Yeung M.L., Yan J., Lu G., Gao G.F. and Yuen K.Y., Carcinoembryonic Antigen-related Cell Adhesion Molecule 5 (CEACAM5) Is an Important Surface Attachment Factor Facilitating the Entry of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV), Journal of Virology. 2016, JVI.01133-16.

Zhao H., Chu H., Zhao X., SHUAI H., Wong H.Y.B., Wen L.R., Yuan S., Zheng B., Zhou J. and Yuen K.Y., Novel residues in the PA protein of avian influenza H7N7 virus affect virulence in mammalian hosts, Virology. 2016, 498: 1-8.

Researcher : Wong LWM

Project Title:	36th Annual Meeting of the American Society for Virology; A Novel Role of PACT in Restriction of Influenza A Virus Replication
Investigator(s):	Wong LWM
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2017
Completion Date:	06/2017

Researcher : Wong MWL

List of Research Outputs

Cheng C.C.V., Chen H.K.J., So S.Y.C., Wong C.Y.S., Chau P.H., Wong M.W.L., Ching H.C.R., Ng L.M.M., Lee W.M., Hung F.N.I., Ho P.L. and Yuen K.Y., A novel risk factor associated with colonization by Carbapenemase-Producing Enterobacteriaceae: Use of Proton Pump Inhibitors in addition to Antimicrobial Treatment, Infection Control & Hospital Epidemiology. 2016, 37: 1418-1425.

Researcher : Wong PC

List of Research Outputs

Woo P.C.Y., Lau S.K.P., Teng L.L., Cao K.Y., Wernery U., Schountz T., Chiu T.H., Tsang K.L., Wong P.C., Wong Y.M. and Yuen K.Y., New Hepatitis E Virus Genotype in Bactrian Camels, Xinjiang, China, 2013, Emerging Infectious Diseases. 2016, 22: 2219-2221.

Woo P.C.Y., Lau S.K.P., Tsang C.C., Lau C.Y., Wong P.C., Chow W.N., Fong J.Y.H. and Yuen K.Y., Coronavirus HKU15 in respiratory tract of pigs and first discovery of coronavirus quasispecies in 5′-untranslated region, Emerging Microbes & Infections. 2017, 6: e53.

Researcher : Wong SC

List of Research Outputs

Cheng C.C.V., Wong S.C., Wong I.W.Y., Chau P.H., So S.Y.C., Wong C.Y.S., Chen H.K.J., Lee W.M., Tai J.W.M., Chau C.H., Lo W.K. and Yuen K.Y., The challenge of patient empowerment in hand hygiene promotion in health care facilities in Hong Kong, American Journal of Infection Control. 2017, 45: 562-565.

Researcher : Wong SCY

List of Research Outputs

Chen H.K.J., Lam H.Y., Yip C.Y., Wong S.C.Y., Chan J.F.W., Ma E.S., Cheng V.C.C., Tang S.F. and Yuen K.Y., Clinical Evaluation of the New High-Throughput Luminex NxTAG Respiratory Pathogen Panel Assay for Multiplex Respiratory Pathogen Detection, Journal of Clinical Microbiology. 2016, 54: 1820-1825.

Wong S.C.Y., Tse H., Chen H.K.J., Cheng V.C.C., Ho P.L. and Yuen K.Y., Colistin-Resistant Enterobacteriaceae Carrying the mcr-1 Gene among Patients in Hong Kong , Emerging Infectious Diseases. 2016, 22: 1667-1669.

Researcher : Wong SSY

Project Title:	Molecular characterization of streptococcus bovis bacteraemia
Investigator(s):	Wong SSY, Yuen KY, Woo PCY
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Project Title:	Characterization of bacterial isolates with ambiguous biochemical profiles recovered from patients with clinically significant bacteremia by 16S rRNA gene sequencing, the state-of-the-art molecular technique for bacterial identification
Investigator(s):	Wong SSY, Woo PCY, Lau SKP
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Project Title:	Discovery and characterization of novel Tsukamurella species: a 14-year retrospective analysis
Investigator(s):	Wong SSY, Teng LL, Lau SKP, Woo PCY
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2015
Completion Date:	05/2017

Project Title:	Genome sequencing of clinical and environmental isolates of Burkholderia pseudomallei: implications for the most common sequence type circulating in Hong Kong
Investigator(s):	Wong SSY, Teng LL, Lau SKP, Woo PCY
Department:	Microbiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

Project Title:	Prevalence of extended spectrum beta-lactamase (ESBL)-producing Laribacter hongkongensis in patients and freshwater fish in Hong Kong
Investigator(s):	Wong SSY, Teng LL, Lau SKP, Woo PCY
Department:	Microbiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

List of Research Outputs

Fang C.X., Wong T.M., To K.K.W., Wong S.S.Y., Lau T.W. and Leung F.K.L., Infection after fracture osteosynthesis – Part II, Journal of Orthopaedic Surgery. 2017, 25: 230949901769271.

Fang C.X., Wong T.M., Lau T.W., To K.K.W., Wong S.S.Y. and Leung F.K.L., Infection after fracture osteosynthesis – Part I, Journal of Orthopaedic Surgery. 2017, 25: 230949901769271.

Lau S.K.P., Ahmed S.S., Yeung C., Li K.S.M., Fan Y.Y., Cheng T.Y., Cai J., Wang M., Zheng B., Wong S.S.Y., Woo P.C.Y. and Yuen K.Y., Identification and interspecies transmission of a novel bocaparvovirus among different bat species in China, The Journal of General Virology. 2016, 97: 3345-3358.

TANG Y., Teng L.L., Cheung C.L., Ngan A.H., Huang Y., Wong S.S.Y., Yip E.K., Ng K.H., Que T.L., Lau S.K.P. and Woo P.C.Y., Tsukamurellaserpentis sp. nov., isolated from the oral cavity of Chinese cobras (Naja atra), International Journal of Systematic and Evolutionary Microbiology. 2016, 66: 3329-3336.

Tang T.H., Wong S.S.Y., Lai C.K., Poon R.W., Chan H.S., Wu T.C., Cheung Y.F., Poon T.L., Tsang Y.P., Tang W.L. and Wu A.K., Molecular Identification of Spirometra erinaceieuropaei Tapeworm in Cases of Human Sparganosis, Hong Kong, Emerging Infectious Diseases. Centers for Disease Control and Prevention, USA, 2017, 23: 665-668.

Teng L.L., Tang Y., Huang Y., Guo F.B., Wei W., Chen J.H.H.K., Wong S.S.Y., Lau S.K.P. and Woo P.C.Y., Phylogenomic Analyses and Reclassification of Species within the Genus Tsukamurella: Insights to Species Definition in the Post-genomic Era, Frontiers in Microbiology. 2016, 7.

Teng L.L., Tang Y., Chiu T.H., Ngan A.H., Ngai C., Wong S.S.Y., Lau S.K.P. and Woo P.C.Y., The groEL gene is a promising target for species-level identification of Tsukamurella, Journal of Clinical Microbiology. American Society for Microbiology, 2017, 55: 649-653.

Wong S.S.Y., Reply to comments on “Zika virus transmission: What to concern on its transmission apart from mosquito control” by Viroj Wiwanitkit, Journal of the Formosan Medical Association. 2016, 115: 685-686.

Wong S.S.Y., The calf vaccinating table, Hong Kong Medical Journal. Hong Kong, Hong Kong Academy of Medicine, 2017, 23: 101-103.

Woo P.C.Y., Lau S.K.P., Lau C.Y., Tung T.K., Chong T.K., Yang F., Zhang H., Lo K.C., Cai J., Au Yeung K.H.R., Ng W.F., Tse H., Wong S.S.Y., Xu S., Lam W.H., Tse M.K., Sze K.H., Kao R.Y.T., Reiner N.E., Hao Q. and Yuen K.Y., Mp1p Is a Virulence Factor in Talaromyces (Penicillium) marneffei, PLOS Neglected Tropical Diseases. 2016, 10: e0004907.

Researcher : Wong TL

List of Research Outputs

Hung F.N.I., To K.K.W., Chan J.F.W., Cheng C.C.V., Liu S.H.K., Tam A., Chan T.C.I., Zhang J., Li P.C.K., Wong T.L., ZHANG R., Cheung M.K.S., Leung W., Lau J.Y., Fok M., Chen H., Chan K.H. and Yuen K.Y., Efficacy of Clarithromycin-Naproxen-Oseltamivir Combination in the Treatment of Patients Hospitalized for Influenza A(H3N2) Infection: an open-label, randomized controlled, phase 2b/3 trial., Chest. 2017, 151: 1069-1080.

Researcher : Wong YM

List of Research Outputs

Chen Y., Chan K.H., Hong C., Kang Y., Ge S., Chen H., Wong Y.M., Joseph S., Patteril N.G., Wernery U., Xia N., Lau S.K.P. and Woo P.C.Y., A highly specific rapid antigen detection assay for on-site diagnosis of MERS., Journal of Infection. 2016, 73: 82-84.

Lau S.K.P., Wernery R., Wong Y.M., Joseph S., Tsang K.L., Patteril N.A., Elizabeth S.K., Chan K.H., Muhammed R., Kinne J., Yuen K.Y., Wernery U. and Woo P.C.Y., Polyphyletic origin of MERS coronaviruses and isolation of a novel clade A strain from dromedary camels in the United Arab Emirates, Emerging Microbes and Infections. 2016, 5: e128.

Woo P.C.Y., Wong Y.M., Wong B.H., Lam S.F., Fan Y.Y., Lau S.K.P. and Yuen K.Y., Comparative genome and evolutionary analysis of naturally occurring Beilong virus in brown and black rats., Infection, Genetics and Evolution. 2016, 45: 311-319.

Woo P.C.Y., Lau S.K.P., Choi G.K.Y., Hunag Y., Sivakumar S., Tsoi H.W., Yip C.C., Jose S.V., BAI R., Wong Y.M., Joesph M., Li T., Wernery U. and Yuen K.Y., Molecular epidemiology of canine picornavirus in Hong Kong and Dubai and proposal of a novel genus in Picornaviridae., Infect Genet Evol.. 2016, 41: 191-200.

Woo P.C.Y., Lau S.K.P., Teng L.L., Cao K.Y., Wernery U., Schountz T., Chiu T.H., Tsang K.L., Wong P.C., Wong Y.M. and Yuen K.Y., New Hepatitis E Virus Genotype in Bactrian Camels, Xinjiang, China, 2013, Emerging Infectious Diseases. 2016, 22: 2219-2221.

Woo P.C.Y., Lau S.K.P., Tsoi H.W., Patteril N.G., Yeung C., Joseph S., Wong Y.M., Muhammed R., Chow W.N., Wernery U. and Yuen K.Y., Two novel dromedary camel bocaparvoviruses from dromedaries in the Middle East with unique genomic features, The Journal of General Virology. 2017, 98: 1349-1359.

Researcher : Wong YP

List of Research Outputs

Woo P.C.Y., Teng L.L., BAI R., Wong Y.P., Martelli P., Hui S.W., Tsang K.L., Lau C.Y., Ahmed S.S., Yip C.Y., CHOI K.Y., Li K.S.M., Lam S.F., Lau S.K.P. and Yuen K.Y., High Diversity of Genogroup I Picobirnaviruses in Mammals, Frontier in microbiology. 2016, 7: 1886.

Researcher : Woo P.C.Y.

Project Title:	Infection and Immunology
Investigator(s):	Woo PCY, Yuen KY, Watt RM
Department:	Microbiology
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	06/2013

Project Title:	Molecular epidemiology of superficial infections by non-dermatophytic moulds in Hong Kong
Investigator(s):	Woo PCY, Lau SKP, Chan JFW
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	12/2014

Project Title:	Molecular basis for interspecies transmission and pathogenesis of Middle East Respiratory Syndrome Coronavirus
Investigator(s):	Woo PCY, Lau SKP, Jin D, Yuen KY, Chen H, Kao RYT, Zheng B, Sham PC, Teng LL, Chan JFW, Tse H, Zhang J, Kok KH, Sze KH, Tanner JA, Yeung ML, Zhou J, Chu H, To KKW
Department:	Microbiology
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	11/2015

Project Title:	Unravelling the pathogenesis of Talaromyces marneffei and generation of candidate vaccines
Investigator(s):	Woo PCY, Lau SKP
Department:	Microbiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2016

Project Title:	Novel Microbe Discovery and Microbial Genomics
Investigator(s):	Woo PCY
Department:	Microbiology
Source(s) of Funding:	Croucher Senior Medical Research Fellowships
Start Date:	01/2016

Project Title:	Genome manipulation of the medically important, thermally dimorphic fungus Talaromyces marneffei
Investigator(s):	Woo PCY, Lau SKP, Kok KH
Department:	Microbiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2017

Project Title:	Development of a rapid antigen detection assay with high specificity and sensitivity for early diagnosis of Middle East Respiratory Syndrome in clinical microbiology laboratories
Investigator(s):	Woo PCY, Lau SKP
Department:	Microbiology
Source(s) of Funding:	Seed Fund for Translational and Applied Research
Start Date:	04/2017

Project Title:	2nd International symposium on infectious diseases of bats 2017; Rapid detection of MERS coronavirus ancestors in bats
Investigator(s):	Woo PCY
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2017
Completion Date:	07/2017

List of Research Outputs

Researcher : Woo PCY

Project Title:	Infection and Immunology
Investigator(s):	Woo PCY, Yuen KY, Watt RM
Department:	Microbiology
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	06/2013

Project Title:	Molecular epidemiology of superficial infections by non-dermatophytic moulds in Hong Kong
Investigator(s):	Woo PCY, Lau SKP, Chan JFW
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	12/2014

Project Title:	Molecular basis for interspecies transmission and pathogenesis of Middle East Respiratory Syndrome Coronavirus
Investigator(s):	Woo PCY, Lau SKP, Jin D, Yuen KY, Chen H, Kao RYT, Zheng B, Sham PC, Teng LL, Chan JFW, Tse H, Zhang J, Kok KH, Sze KH, Tanner JA, Yeung ML, Zhou J, Chu H, To KKW
Department:	Microbiology
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	11/2015

Project Title:	Unravelling the pathogenesis of Talaromyces marneffei and generation of candidate vaccines
Investigator(s):	Woo PCY, Lau SKP
Department:	Microbiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2016

Project Title:	Novel Microbe Discovery and Microbial Genomics
Investigator(s):	Woo PCY
Department:	Microbiology
Source(s) of Funding:	Croucher Senior Medical Research Fellowships
Start Date:	01/2016

Project Title:	Genome manipulation of the medically important, thermally dimorphic fungus Talaromyces marneffei
Investigator(s):	Woo PCY, Lau SKP, Kok KH
Department:	Microbiology
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2017

Project Title:	Development of a rapid antigen detection assay with high specificity and sensitivity for early diagnosis of Middle East Respiratory Syndrome in clinical microbiology laboratories
Investigator(s):	Woo PCY, Lau SKP
Department:	Microbiology
Source(s) of Funding:	Seed Fund for Translational and Applied Research
Start Date:	04/2017

Project Title:	2nd International symposium on infectious diseases of bats 2017; Rapid detection of MERS coronavirus ancestors in bats
Investigator(s):	Woo PCY
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2017
Completion Date:	07/2017

List of Research Outputs

Chan J.F.W., Sridhar S., Yip C.Y., Lau S.K.P. and Woo P.C.Y., The role of laboratory diagnostics in emerging viral infections: the example of the Middle East respiratory syndrome epidemic, Journal of Microbiology. 2017, 55: 172-182.

Chen Y., Chan K.H., Hong C., Kang Y., Ge S., Chen H., Wong Y.M., Joseph S., Patteril N.G., Wernery U., Xia N., Lau S.K.P. and Woo P.C.Y., A highly specific rapid antigen detection assay for on-site diagnosis of MERS., Journal of Infection. 2016, 73: 82-84.

Guo F.B., Xiong L., Zhang K.Y., Dong C., Zhang F.Z. and Woo P.C.Y., Identification and analysis of genomic islands in Burkholderia cenocepacia AU 1054 with emphasis on pathogenicity islands, BMC Microbiology. 2017, 17: 73.

HUO Y., Chan Y.K., Lacap-Bugler D.C., Mo S., Woo P.C.Y., Leung W.K. and Watt R.M., Multilocus Sequence Analysis of Phylogroup 1 and 2 Oral Treponeme Strains, Applied and Environmental Microbiology. 2017, 83: e02499-16.

Heshiki Y., Dissanayake T., Zheng T., Kang K., Ni Y.Q., Xu Z.L., Sarkar C., Woo P.C.Y., Chow B.K.C., Baker D.M., Yan A., Webster C.J., Panagiotou I. and Li J., Toward a Metagenomic Understanding on the Bacterial Composition and Resistome in Hong Kong Banknotes, Frontiers in Microbiology. 2017, 8: 632 (1-12).

Kong H.K., Law H.W., Liu X., Law C.O., Pan Q., Gao L., Xiong L., Lau S.K.P., Woo P.C.Y. and Lau T.C., Transcriptomic Analysis of Laribacter hongkongensis Reveals Adaptive Response Coupled with Temperature, PLoS One. 2017, 12: e0169998.

Lau S.K.P., Yeung C., Li K.S.M., Lam S.F., Cai J., Yuen M.C., Wang M., Zheng B., Woo P.C.Y. and Yuen K.Y., Identification and genomic characterization of a novel rat bocavirus from brown rats in China, Infection, Genetics and Evolution. 2017, 47: 68-76.

Lau S.K.P., Ahmed S.S., Yeung C., Li K.S.M., Fan Y.Y., Cheng T.Y., Cai J., Wang M., Zheng B., Wong S.S.Y., Woo P.C.Y. and Yuen K.Y., Identification and interspecies transmission of a novel bocaparvovirus among different bat species in China, The Journal of General Virology. 2016, 97: 3345-3358.

Lau S.K.P., Woo P.C.Y., Li K.S.M., Zhang H.J., Fan Y.Y., Zhang J., Chan B.C., Lam S.F., Yip C.Y., Yuen M.C., Chan K.H., Chen Z. and Yuen K.Y., Identification of Novel Rosavirus Species That Infects Diverse Rodent Species and Causes Multisystemic Dissemination in Mouse Model, PLoS Pathogen. 2016, 12: e1005911.

Lau S.K.P., Lo C.S., Lam C.S., Chow W.N., Ngan A.H., Wu A.K., Tsang D.N., Tse C.W., Que T.L., Tang B.S. and Woo P.C.Y., In Vitro Activity of Posaconazole against Talaromyces marneffei by Broth Microdilution and Etest Methods and Comparison to Itraconazole, Voriconazole, and Anidulafungin, Antimicrobial Agents and Chemotherapy. 2017, 61: e01480-16.

Lau S.K.P., Chan J.F.W., Hung F.N.I., Cheng V.C.C., Sridhar S., Yip C.Y., Chan K.H. and Woo P.C.Y., Middle East Respiratory Syndrome Interpreted: Human Herpesvirus 6B Pneumonia, The American Journal of Medicine. 2016, 129(9): 945-7.

Lau S.K.P., Wernery R., Wong Y.M., Joseph S., Tsang K.L., Patteril N.A., Elizabeth S.K., Chan K.H., Muhammed R., Kinne J., Yuen K.Y., Wernery U. and Woo P.C.Y., Polyphyletic origin of MERS coronaviruses and isolation of a novel clade A strain from dromedary camels in the United Arab Emirates, Emerging Microbes and Infections. 2016, 5: e128.

Lau S.K.P., Tsang C.C. and Woo P.C.Y., Talaromyces marneffei genomic, transcriptomic, proteomic and metabolomic studies reveal mechanisms for environmental adaptations and virulence, Toxins. 2017, 9: 192.

Lau S.Y., Joseph S., Chan K.H., Chen H., Patteril N.A., Elizabeth S.K., Muhammed R., Baskar V., Lau S.K.P., Kinne J., Wernery U. and Woo P.C.Y., Complete Genome Sequence of Influenza Virus H9N2 Associated with a Fatal Outbreak among Chickens in Dubai., Genome Announcement. 2016, 4: e00752-16.

Li H., Yang X., WANG R., KOOHIMOGHADAM M., Woo P.C.Y., Kao R.Y.T. and Sun H., UreG as a target for the development of urease inhibitor: a new strategy for design of antimicrobial agents, 8th Asian Biological Inorganic Chemistry Conference. 2016.

Sridhar S., Teng L.L., Chiu T.H., Lau S.K.P. and Woo P.C.Y., Hepatitis E Virus Genotypes and Evolution: Emergence of Camel Hepatitis E Variants, International Journal of Molecular Sciences. 2017, 18: 869.

Sze K.H., Lam W.H., Zhang H., Ke Y., Tse M.K., Woo P.C.Y., Lau S.K.P., Lau C.Y., Cai J., Tung E.T., Lo R.K., Xu S., Kao R.Y.T., Hao Q. and Yuen K.Y., Talaromyces marneffei Mp1p Is a Virulence Factor that Binds and Sequesters a Key Proinflammatory Lipid to Dampen Host Innate Immune Response, Cell Chemical Biology. 2017, 24: 182-194.

TANG Y., Teng L.L., Cheung C.L., Ngan A.H., Huang Y., Wong S.S.Y., Yip E.K., Ng K.H., Que T.L., Lau S.K.P. and Woo P.C.Y., Tsukamurellaserpentis sp. nov., isolated from the oral cavity of Chinese cobras (Naja atra), International Journal of Systematic and Evolutionary Microbiology. 2016, 66: 3329-3336.

TSANG C.C., Chan J.F.W., Pong W.M., Chen H.K.J., Ngan A.H.Y., Cheung M., Lai C.K.C., Tsang D.N.C., Lau S.K.P. and Woo P.C.Y., Cutaneous hyalohyphomycosis due to Parengyodontium album gen. et comb. nov. , Medical Mycology. 2016, 54: 699-713.

TSANG C.C., Xiong L., Poon W.S.R., Chen H.K.J., Leung K.W., Lam J.Y.W., Wu K.L.A., Chan J.F.W., Lau S.K.P. and Woo P.C.Y., Gordonia hongkongensis sp. nov., isolated from blood culture and peritoneal dialysis effluent of patients in Hong Kong, International Journal of Systematic and Evolutionary Microbiology. 2016, 66: 3942-3950.

Tam W.T., TSANG C.C., Lau S.K.P. and Woo P.C.Y., Comparative mitogenomic and phylogenetic characterization on the complete mitogenomes of Talaromyces (Penicillium) marneffei , Mitochondrial DNA Part B. 2016, 1: 941-942.

Teng L.L., Tang Y., Huang Y., Guo F.B., Wei W., Chen J.H.H.K., Wong S.S.Y., Lau S.K.P. and Woo P.C.Y., Phylogenomic Analyses and Reclassification of Species within the Genus Tsukamurella: Insights to Species Definition in the Post-genomic Era, Frontiers in Microbiology. 2016, 7.

Teng L.L., Tang Y., Chiu T.H., Ngan A.H., Ngai C., Wong S.S.Y., Lau S.K.P. and Woo P.C.Y., The groEL gene is a promising target for species-level identification of Tsukamurella, Journal of Clinical Microbiology. American Society for Microbiology, 2017, 55: 649-653.

Thu N.T.M., Chan J.F.W., Hien H.T.A., Tung N.L.N., Thanh N.T.T., Day J., Chau N.V.V., Thwaites G., Woo P.C.Y., Yuen K.Y. and Le T., Clinical Performance of the Mp1p Immunoassay for Rapid Diagnosis of Talaromyces marneffei Infection, Conference on Retroviruses and Opportunistic Infections. 2017.

To K.K.W., Chan W.M., Li K.S.M., Lam S.F., Chen Z., Tse H., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., High prevalence of four novel astrovirus genotype species identified from rodents in China, Journal of General Virology. 2017, 98: 1004-1015.

Wang J., Teng L.L., Zhao D., Ge P., Li B., Woo P.C.Y. and Liu C.H., The ubiquitin ligase TRIM27 functions as a host restriction factor antagonized by Mycobacterium tuberculosis PtpA during mycobacterial infection, Scientific reports. 2016, 6: 34827.

Wernery U., Lau S.K.P. and Woo P.C.Y., Middle East respiratory syndrome (MERS) coronavirus and dromedaries, Veterinary Journal. 2017, 220: 75-79.

Woo P.C.Y., Wong Y.M., Wong B.H., Lam S.F., Fan Y.Y., Lau S.K.P. and Yuen K.Y., Comparative genome and evolutionary analysis of naturally occurring Beilong virus in brown and black rats., Infection, Genetics and Evolution. 2016, 45: 311-319.

Woo P.C.Y., Epidemiology and recommendation on adult pneumococcal vaccination in Hong Kong, Taiwan adult pneumococcal disease expert meeting, Taipei, Taiwan.. 2017.

Woo P.C.Y., Teng L.L., BAI R., Wong Y.P., Martelli P., Hui S.W., Tsang K.L., Lau C.Y., Ahmed S.S., Yip C.Y., CHOI K.Y., Li K.S.M., Lam S.F., Lau S.K.P. and Yuen K.Y., High Diversity of Genogroup I Picobirnaviruses in Mammals, Frontier in microbiology. 2016, 7: 1886.

Woo P.C.Y., Lau S.K.P., Choi G.K.Y., Hunag Y., Sivakumar S., Tsoi H.W., Yip C.C., Jose S.V., BAI R., Wong Y.M., Joesph M., Li T., Wernery U. and Yuen K.Y., Molecular epidemiology of canine picornavirus in Hong Kong and Dubai and proposal of a novel genus in Picornaviridae., Infect Genet Evol.. 2016, 41: 191-200.

Woo P.C.Y., Lau S.K.P., Lau C.Y., Tung T.K., Chong T.K., Yang F., Zhang H., Lo K.C., Cai J., Au Yeung K.H.R., Ng W.F., Tse H., Wong S.S.Y., Xu S., Lam W.H., Tse M.K., Sze K.H., Kao R.Y.T., Reiner N.E., Hao Q. and Yuen K.Y., Mp1p Is a Virulence Factor in Talaromyces (Penicillium) marneffei, PLOS Neglected Tropical Diseases. 2016, 10: e0004907.

Woo P.C.Y., Lau S.K.P., Teng L.L., Cao K.Y., Wernery U., Schountz T., Chiu T.H., Tsang K.L., Wong P.C., Wong Y.M. and Yuen K.Y., New Hepatitis E Virus Genotype in Bactrian Camels, Xinjiang, China, 2013, Emerging Infectious Diseases. 2016, 22: 2219-2221.

Woo P.C.Y., Rapid detection of MERS coronavirus ancestors in bats, Second international symposium on infectious disease of bats, Fort Collins, USA.. 2017.

Woo P.C.Y., Lau S.K.P., Tsoi H.W., Patteril N.G., Yeung C., Joseph S., Wong Y.M., Muhammed R., Chow W.N., Wernery U. and Yuen K.Y., Two novel dromedary camel bocaparvoviruses from dromedaries in the Middle East with unique genomic features, The Journal of General Virology. 2017, 98: 1349-1359.

Woo P.C.Y., Lau S.K.P., Tsang C.C., Lau C.Y., Wong P.C., Chow W.N., Fong J.Y.H. and Yuen K.Y., Coronavirus HKU15 in respiratory tract of pigs and first discovery of coronavirus quasispecies in 5′-untranslated region, Emerging Microbes & Infections. 2017, 6: e53.

Xiong L., Yang Y., Ye Y.N., Teng L.L., Chan E., Watt R.M., Guo F.B., Lau S.K.P. and Woo P.C.Y., Laribacter hongkongensis anaerobic adaptation mediated by arginine metabolism is controlled by the cooperation of FNR and ArgR, Environmental Microbiology. 2017, 19: 1266-1280.

Yip C.Y., Lo J.Y.C., Sridhar S., Lung D.C., Luk S., Chan K.H., Chan J.F.W., Cheng C.C.V., Woo P.C.Y., Yuen K.Y. and Lau S.K.P., First Report of a Fatal Case Associated with EV-D68 Infection in Hong Kong and Emergence of an Interclade Recombinant in China Revealed by Genome Analysis, International Journal of Molecular Sciences. 2017, 18: e1065.

Researcher : Wu KLA

List of Research Outputs

TSANG C.C., Xiong L., Poon W.S.R., Chen H.K.J., Leung K.W., Lam J.Y.W., Wu K.L.A., Chan J.F.W., Lau S.K.P. and Woo P.C.Y., Gordonia hongkongensis sp. nov., isolated from blood culture and peritoneal dialysis effluent of patients in Hong Kong, International Journal of Systematic and Evolutionary Microbiology. 2016, 66: 3942-3950.

Researcher : Xiong L

List of Research Outputs

Guo F.B., Xiong L., Zhang K.Y., Dong C., Zhang F.Z. and Woo P.C.Y., Identification and analysis of genomic islands in Burkholderia cenocepacia AU 1054 with emphasis on pathogenicity islands, BMC Microbiology. 2017, 17: 73.

Kong H.K., Law H.W., Liu X., Law C.O., Pan Q., Gao L., Xiong L., Lau S.K.P., Woo P.C.Y. and Lau T.C., Transcriptomic Analysis of Laribacter hongkongensis Reveals Adaptive Response Coupled with Temperature, PLoS One. 2017, 12: e0169998.

SUN T., LI C., Xiong L., NING Z., Leung F.K.L., PENG S.L. and Lu W.W., miR-375-3p negatively regulates osteogenesis by targeting and decreasing the expression levels of LRP5 and beta-catenin, PLOS ONE. 2017, 12(2).

TSANG C.C., Xiong L., Poon W.S.R., Chen H.K.J., Leung K.W., Lam J.Y.W., Wu K.L.A., Chan J.F.W., Lau S.K.P. and Woo P.C.Y., Gordonia hongkongensis sp. nov., isolated from blood culture and peritoneal dialysis effluent of patients in Hong Kong, International Journal of Systematic and Evolutionary Microbiology. 2016, 66: 3942-3950.

Xiong L., Yang Y., Ye Y.N., Teng L.L., Chan E., Watt R.M., Guo F.B., Lau S.K.P. and Woo P.C.Y., Laribacter hongkongensis anaerobic adaptation mediated by arginine metabolism is controlled by the cooperation of FNR and ArgR, Environmental Microbiology. 2017, 19: 1266-1280.

Xiong L., Molecular Basis For Resisting Acidic Condition And Anaerobicity Of Laribacter Hongkongensis, Invitation from Prof. Biao Kan, National Institute for Communicable Disease Control And Prevention, China CDC. 2016.

Researcher : Xu S

List of Research Outputs

Sze K.H., Lam W.H., Zhang H., Ke Y., Tse M.K., Woo P.C.Y., Lau S.K.P., Lau C.Y., Cai J., Tung E.T., Lo R.K., Xu S., Kao R.Y.T., Hao Q. and Yuen K.Y., Talaromyces marneffei Mp1p Is a Virulence Factor that Binds and Sequesters a Key Proinflammatory Lipid to Dampen Host Innate Immune Response, Cell Chemical Biology. 2017, 24: 182-194.

Woo P.C.Y., Lau S.K.P., Lau C.Y., Tung T.K., Chong T.K., Yang F., Zhang H., Lo K.C., Cai J., Au Yeung K.H.R., Ng W.F., Tse H., Wong S.S.Y., Xu S., Lam W.H., Tse M.K., Sze K.H., Kao R.Y.T., Reiner N.E., Hao Q. and Yuen K.Y., Mp1p Is a Virulence Factor in Talaromyces (Penicillium) marneffei, PLOS Neglected Tropical Diseases. 2016, 10: e0004907.

Researcher : YUEN CK

List of Research Outputs

FUNG S.Y., YUEN C.K., ZHU W., LIANG G., Kok K.H., Chan C.P. and Jin D., Activation of nucleic acid sensing cGAS-STING pathway by Sindbis Virus, 2017 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2017.

FUNG S.Y., Chan C.P., YUEN C.K., Kok K.H., Chan C.P. and Jin D., Human T-cell leukemia virus type 1 Tax and HBZ proteins differentially suppress RNA- and DNA-induced innate antiviral response., 18th International Conference on Human Retrovirology: HTLV-1 and Related Viruses, Tokyo, Japan, March 7-10, 2017.. 2017.

Researcher : Yam WC

Project Title:	Detection of HIV-1 minority drug-resistant and X4-tropic variants by Next-Generation Sequencing to improve the prediction of clinical antiretroviral treatment outcome
Investigator(s):	Yam WC, To WCS, Panagiotou I, Li J
Department:	Microbiology
Source(s) of Funding:	Council for the AIDS Trust Fund - General Award
Start Date:	04/2016

Researcher : Yang D

List of Research Outputs

Chan C.M., Chu H., Wang Y., Wong H.Y.B., Zhao X., Zhou J., Yang D., Leung A.S.P., Chan J.F.W., Yeung M.L., Yan J., Lu G., Gao G.F. and Yuen K.Y., Carcinoembryonic Antigen-related Cell Adhesion Molecule 5 (CEACAM5) Is an Important Surface Attachment Factor Facilitating the Entry of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV), Journal of Virology. 2016, JVI.01133-16.

Ye Z., Yuan S., Poon K.M., Wen L.R., Yang D., Sun Z., Li C., Hu M., Shuai H., Zhou J., Zhang M., Zheng B., Chu H. and Yuen K.Y., Antibody-Dependent Cell-Mediated Cytotoxicity Epitopes on the Hemagglutinin Head Region of Pandemic H1N1 Influenza Virus Play Detrimental Roles in H1N1-Infected Mice, Frontiers in Immunology. Frontiers, 2017, 8: 317.

Researcher : Yang F

List of Research Outputs

Woo P.C.Y., Lau S.K.P., Lau C.Y., Tung T.K., Chong T.K., Yang F., Zhang H., Lo K.C., Cai J., Au Yeung K.H.R., Ng W.F., Tse H., Wong S.S.Y., Xu S., Lam W.H., Tse M.K., Sze K.H., Kao R.Y.T., Reiner N.E., Hao Q. and Yuen K.Y., Mp1p Is a Virulence Factor in Talaromyces (Penicillium) marneffei, PLOS Neglected Tropical Diseases. 2016, 10: e0004907.

Researcher : Yang Y

List of Research Outputs

Xiong L., Yang Y., Ye Y.N., Teng L.L., Chan E., Watt R.M., Guo F.B., Lau S.K.P. and Woo P.C.Y., Laribacter hongkongensis anaerobic adaptation mediated by arginine metabolism is controlled by the cooperation of FNR and ArgR, Environmental Microbiology. 2017, 19: 1266-1280.

Researcher : Ye J

List of Research Outputs

Yuan S., Chu H., Zhang K., Ye J., SINGH K., Kao R.Y.T., Chow B.K.C., Zhou J. and Zheng B., A novel small-molecule compound disrupts influenza A virus PB2 cap-binding and inhibits viral replication, Journal of Antimicrobial Chemotherapy. 2016, 71: 2489-2497.

Yuan S., Chu H., Ye J., SINGH K., Ye Z., Zhao H., Kao R.Y.T., Chow B.K.C., Zhou J. and Zheng B., Identification of a novel small-molecule compound targeting the influenza A virus polymerase PB1-PB2 interface, Antiviral Research. NETHERLANDS, ELSEVIER SCIENCE BV, 2016, 137: 58-66.

Yuan S., Chu H., Ye J., Hu M., SINGH K., Chow B.K.C., Zhou J. and Zheng B., Peptide-Mediated Interference of PB2-eIF4G1 Interaction Inhibits Influenza A Viruses’ Replication in Vitro and in Vivo, ACS Infectious Diseases. 2016, 2: 471-477.

Researcher : Ye Z

List of Research Outputs

Hu M., Yuan S., Ye Z., SINGH K., Li C., SHUAI H., Ng F., Chow B.K.C., Chu H. and Zheng B., PA N substitutions A37S, A37S/I61T and A37S/V63I attenuate the replication of H7N7 influenza A virus by impairing the polymerase and endonuclease activities, Journal of General Virology. 2017, 98: 364-373.

Ye Z., Yuan S., Poon K.M., Wen L.R., Yang D., Sun Z., Li C., Hu M., Shuai H., Zhou J., Zhang M., Zheng B., Chu H. and Yuen K.Y., Antibody-Dependent Cell-Mediated Cytotoxicity Epitopes on the Hemagglutinin Head Region of Pandemic H1N1 Influenza Virus Play Detrimental Roles in H1N1-Infected Mice, Frontiers in Immunology. Frontiers, 2017, 8: 317.

Yuan S., Chu H., Ye J., SINGH K., Ye Z., Zhao H., Kao R.Y.T., Chow B.K.C., Zhou J. and Zheng B., Identification of a novel small-molecule compound targeting the influenza A virus polymerase PB1-PB2 interface, Antiviral Research. NETHERLANDS, ELSEVIER SCIENCE BV, 2016, 137: 58-66.

Researcher : Yeung C

List of Research Outputs

Lau S.K.P., Yeung C., Li K.S.M., Lam S.F., Cai J., Yuen M.C., Wang M., Zheng B., Woo P.C.Y. and Yuen K.Y., Identification and genomic characterization of a novel rat bocavirus from brown rats in China, Infection, Genetics and Evolution. 2017, 47: 68-76.

Lau S.K.P., Ahmed S.S., Yeung C., Li K.S.M., Fan Y.Y., Cheng T.Y., Cai J., Wang M., Zheng B., Wong S.S.Y., Woo P.C.Y. and Yuen K.Y., Identification and interspecies transmission of a novel bocaparvovirus among different bat species in China, The Journal of General Virology. 2016, 97: 3345-3358.

Woo P.C.Y., Lau S.K.P., Tsoi H.W., Patteril N.G., Yeung C., Joseph S., Wong Y.M., Muhammed R., Chow W.N., Wernery U. and Yuen K.Y., Two novel dromedary camel bocaparvoviruses from dromedaries in the Middle East with unique genomic features, The Journal of General Virology. 2017, 98: 1349-1359.

Researcher : Yeung ML

Project Title:	Pathogenesis of Middle East Respiratory Syndrome Coronavirus (MERS-CoV)-associated renal failure
Investigator(s):	Yeung ML, Yuen KY
Department:	Microbiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2015

List of Research Outputs

Chan C.M., Chu H., Wang Y., Wong H.Y.B., Zhao X., Zhou J., Yang D., Leung A.S.P., Chan J.F.W., Yeung M.L., Yan J., Lu G., Gao G.F. and Yuen K.Y., Carcinoembryonic Antigen-related Cell Adhesion Molecule 5 (CEACAM5) Is an Important Surface Attachment Factor Facilitating the Entry of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV), Journal of Virology. 2016, JVI.01133-16.

Researcher : Yip CY

List of Research Outputs

Chan J.F.W., Zhang J., Chan C.S., Yip C.Y., Mak W.N., Zhu H., Poon K.M., Tee K.M., Zhu Z., Cai J., Tsang O.L., Chik K.K.H., Yin F., Chan K.H., Kok K.H., Jin D., Au Yeung K.H.R. and Yuen K.Y., Characterization of a novel mouse model for Zika virus infection using dexamethasone-immunosuppressed mice, First International Conference on Zika Virus. 2017.

Chan J.F.W., Chan K.H., Yuan S., CHIK K.K.H., ZHU Z., Tee K.M., TSANG O.L., Yip C.Y., Poon K.M., Chan C.S., Mak W.N., Zhang J. and Yuen K.Y., Development of an in ovo system for evaluation of antivirals against Zika virus, 30th International Conference on Antiviral Research (ICAR). 2017.

Chan J.F.W., Yip C.Y., Tsang O.L., Tee K.M., Cai J., Chik K.K.H., Zhu Z., Chan C.S., CHOI K.Y., Sridhar S., Zhang J., Lu G., Chiu K., Lo A.C.Y., Tsao G.S.W., Kok K.H., Jin D., Chan K.H. and Yuen K.Y., Differential cell line susceptibility to the emerging Zika virus: implications for disease pathogenesis, non-vector-borne human transmission and animal reservoirs, Emerging Microbes & Infections. 2016, 5: e93.

Chan J.F.W., Yip C.Y., Tee K.M., Zhu Z., Tsang O.L., Chik K.K.H., TSANG G.W.T., Chan C.S., Poon K.M., Sridhar S., Yin F., Hung F.N.I., Chau S.K.Y., Zhang J., Chan K.H. and Yuen K.Y., Improved detection of Zika virus RNA in human and animal specimens by a novel, highly sensitive and specific real-time RT-PCR assay targeting the 5′-untranslated region of Zika virus, Tropical Medicine & International Health. 2017, 22: 594-603.

Chan J.F.W., CHIK K.K.H., Yuan S., Yip C.Y., ZHU Z., Tee K.M., TSANG O.L., Chan C.S., Poon K.M., Lu G., Zhang J., Lai K.K., Chan K.H., Kao R.Y.T. and Yuen K.Y., Novel antiviral activity and mechanism of bromocriptine as a Zika virus NS2B-NS3 protease inhibitor, Antiviral Research. 2017, 141: 29-37.

Chan J.F.W., Yip C.Y., Ho T.Y., Chan K.H., Hung F.N.I. and Yuen K.Y., Surveillance for Zika virus infection among asymptomatic returning travelers from the Rio Olympic and Paralymic Games, 33rd ASM Clinical Virology Symposium. 2017.

Chan J.F.W., Sridhar S., Yip C.Y., Lau S.K.P. and Woo P.C.Y., The role of laboratory diagnostics in emerging viral infections: the example of the Middle East respiratory syndrome epidemic, Journal of Microbiology. 2017, 55: 172-182.

Chan J.F.W., Zhang J., Chan C.S., Yip C.Y., Mak W.N., Zhu H., Poon K.M., Tee K.M., Zhu Z., Cai J., Tsang O.L., Chik K.K.H., Yin F., Chan K.H., Kok K.H., Jin D., Au Yeung K.H.R. and Yuen K.Y., Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons, EBioMedicine. 2016, 14: 112-122.

Chen H.K.J., Lam H.Y., Yip C.Y., Wong S.C.Y., Chan J.F.W., Ma E.S., Cheng V.C.C., Tang S.F. and Yuen K.Y., Clinical Evaluation of the New High-Throughput Luminex NxTAG Respiratory Pathogen Panel Assay for Multiplex Respiratory Pathogen Detection, Journal of Clinical Microbiology. 2016, 54: 1820-1825.

Lau S.K.P., Woo P.C.Y., Li K.S.M., Zhang H.J., Fan Y.Y., Zhang J., Chan B.C., Lam S.F., Yip C.Y., Yuen M.C., Chan K.H., Chen Z. and Yuen K.Y., Identification of Novel Rosavirus Species That Infects Diverse Rodent Species and Causes Multisystemic Dissemination in Mouse Model, PLoS Pathogen. 2016, 12: e1005911.

Lau S.K.P., Chan J.F.W., Hung F.N.I., Cheng V.C.C., Sridhar S., Yip C.Y., Chan K.H. and Woo P.C.Y., Middle East Respiratory Syndrome Interpreted: Human Herpesvirus 6B Pneumonia, The American Journal of Medicine. 2016, 129(9): 945-7.

To K.K.W., Lu L., Yip C.Y., Poon W.S.R., Fung A.M.Y., Cheng A., Lui D.H.K., Ho T.Y., Hung F.N.I., Chan K.H. and Yuen K.Y., Additional molecular testing of saliva specimens improves the detection of respiratory viruses, Emerging Microbes & Infections. 2017, 6: e49.

Woo P.C.Y., Teng L.L., BAI R., Wong Y.P., Martelli P., Hui S.W., Tsang K.L., Lau C.Y., Ahmed S.S., Yip C.Y., CHOI K.Y., Li K.S.M., Lam S.F., Lau S.K.P. and Yuen K.Y., High Diversity of Genogroup I Picobirnaviruses in Mammals, Frontier in microbiology. 2016, 7: 1886.

Yip C.Y., Tee K.M., Zhu Z., Chik K.K.H., Tsang O.L., Poon K.M., Chan C.S., Zhang J., Chan K.H., Yuen K.Y. and Chan J.F.W., Development and evaluation of a novel real-time RT-PCR assay targeting the envelope gene of the African and Asian/American lineages of the emerging Zika virus, 3rd Microbiology Asia Congress. 2016.

Yip C.Y., Lo J.Y.C., Sridhar S., Lung D.C., Luk S., Chan K.H., Chan J.F.W., Cheng C.C.V., Woo P.C.Y., Yuen K.Y. and Lau S.K.P., First Report of a Fatal Case Associated with EV-D68 Infection in Hong Kong and Emergence of an Interclade Recombinant in China Revealed by Genome Analysis, International Journal of Molecular Sciences. 2017, 18: e1065.

Yip C.Y., Tee K.M., ZHU Z., TSANG O.L., CHIK K.K.H., TSANG G.W.T., Chan C.S., Poon K.M., Sridhar S., Yin F., Hung F.N.I., Chau S.K.Y., Zhang J., Chan K.H., Yuen K.Y. and Chan J.F.W., Improved detection of Zika virus RNA in human and animal specimens by a novel, highly sensitive and specific real-time RT-PCR assay targeting the 5'-untranslated region of Zika virus, 33rd ASM Clinical Virology Symposium. 2017.

Researcher : Yuan S

Project Title:	Development of Anti-influenza Agents Targeting Influenza Virus RNA Polymerase
Investigator(s):	Yuan S, Kao RYT, Zhou J, Zheng B
Department:	Microbiology
Source(s) of Funding:	Matching Grant for Joint Research
Start Date:	07/2015

List of Research Outputs

Chan J.F.W., Chan K.H., Yuan S., CHIK K.K.H., ZHU Z., Tee K.M., TSANG O.L., Yip C.Y., Poon K.M., Chan C.S., Mak W.N., Zhang J. and Yuen K.Y., Development of an in ovo system for evaluation of antivirals against Zika virus, 30th International Conference on Antiviral Research (ICAR). 2017.

Chan J.F.W., CHIK K.K.H., Yuan S., Kao R.Y.T. and Yuen K.Y., Identification of bromocriptine as a Zika virus NS2B-NS3 protease inhibitor, American Society for Virology (ASV) 36th Annual Meeting. 2017.

Chan J.F.W., CHIK K.K.H., Yuan S., Yip C.Y., ZHU Z., Tee K.M., TSANG O.L., Chan C.S., Poon K.M., Lu G., Zhang J., Lai K.K., Chan K.H., Kao R.Y.T. and Yuen K.Y., Novel antiviral activity and mechanism of bromocriptine as a Zika virus NS2B-NS3 protease inhibitor, Antiviral Research. 2017, 141: 29-37.

HU M., Chu H., Zhang K., SINGH K., Li C., Yuan S., Chow B.K.C., Song W., Zhou J. and Zheng B., Amino acid substitutions V63I or A37S/I61T/V63I/V100A in the PA N-terminal domain increase the virulence of H7N7 influenza A virus, Scientific Reports. ENGLAND, Nature Publishing Group, 2016, 6: 37800.

Hu M., Yuan S., Ye Z., SINGH K., Li C., SHUAI H., Ng F., Chow B.K.C., Chu H. and Zheng B., PA N substitutions A37S, A37S/I61T and A37S/V63I attenuate the replication of H7N7 influenza A virus by impairing the polymerase and endonuclease activities, Journal of General Virology. 2017, 98: 364-373.

Ye Z., Yuan S., Poon K.M., Wen L.R., Yang D., Sun Z., Li C., Hu M., Shuai H., Zhou J., Zhang M., Zheng B., Chu H. and Yuen K.Y., Antibody-Dependent Cell-Mediated Cytotoxicity Epitopes on the Hemagglutinin Head Region of Pandemic H1N1 Influenza Virus Play Detrimental Roles in H1N1-Infected Mice, Frontiers in Immunology. Frontiers, 2017, 8: 317.

Yuan S. and Zheng B., A Novel Small-molecule Compound Disrupts Influenza A Virus PB2 Cap-binding and Inhibits Viral Replication , Options IX for the Control of Influenza. 2016.

Yuan S., Chu H., Zhang K., Ye J., SINGH K., Kao R.Y.T., Chow B.K.C., Zhou J. and Zheng B., A novel small-molecule compound disrupts influenza A virus PB2 cap-binding and inhibits viral replication, Journal of Antimicrobial Chemotherapy. 2016, 71: 2489-2497.

Yuan S., Chu H., Ye J., SINGH K., Ye Z., Zhao H., Kao R.Y.T., Chow B.K.C., Zhou J. and Zheng B., Identification of a novel small-molecule compound targeting the influenza A virus polymerase PB1-PB2 interface, Antiviral Research. NETHERLANDS, ELSEVIER SCIENCE BV, 2016, 137: 58-66.

Yuan S., Chu H., Ye J., Hu M., SINGH K., Chow B.K.C., Zhou J. and Zheng B., Peptide-Mediated Interference of PB2-eIF4G1 Interaction Inhibits Influenza A Viruses’ Replication in Vitro and in Vivo, ACS Infectious Diseases. 2016, 2: 471-477.

Zhao H., Chu H., Zhao X., SHUAI H., Wong H.Y.B., Wen L.R., Yuan S., Zheng B., Zhou J. and Yuen K.Y., Novel residues in the PA protein of avian influenza H7N7 virus affect virulence in mammalian hosts, Virology. 2016, 498: 1-8.

Researcher : Yuen CKJ

List of Research Outputs

Chan C.P., Yuen C.K.J., Fung S.Y., CHEUNG P.H.H., Chen H., Kok K.H. and Jin D., Antiviral activity of double-stranded RNA-binding protein PACT against influenza A virus mediated through suppression of viral RNA polymerase, FOCIS 2017.

Researcher : Yuen K.Y.

Project Title:	Establishment of core facilities for the HKU HIV/AIDS research laboratories
Investigator(s):	Yuen KY, Zheng B, Woo PCY, Yam WC, Im SWK
Department:	Microbiology
Source(s) of Funding:	Council for the AIDS Trust Fund - General Award
Start Date:	11/2001

Project Title:	Special Research Achievement Award 2003-2004
Investigator(s):	Yuen KY
Department:	Microbiology
Source(s) of Funding:	Special Research Achievement Award
Start Date:	11/2004

Project Title:	Bacteraemia caused by Anaerotruncus colihominis and emended description of the species
Investigator(s):	Yuen KY, Lau SKP, Woo PCY
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	09/2005

Project Title:	Investigation of invasive Lasiodiplodia theobromae infections in humans
Investigator(s):	Yuen KY, Tse H, Woo PCY, Lau SKP
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	09/2007

Project Title:	Molecular epidemiological investigation of PARV-4-related viruses in HK and southern China
Investigator(s):	Yuen KY, Tse H, Lau SKP, Woo PCY
Department:	Microbiology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	10/2008

Project Title:	Understanding the evolution and interspecies transmission of betacoronaviruses by structural and biophysical approaches
Investigator(s):	Yuen KY, Woo PCY, Lau SKP, Chan JFW
Department:	Microbiology
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2015

Project Title:	Control of viral and multidrug resistant bacterial infections relevant to Hong Kong SAR
Investigator(s):	Yuen KY, Jin D, Lau SKP, To KKW, Chan JFW, Sze KH, Tse H, Woo PCY, Hung FNI, Huang J, Ho PL, Kao RYT, Cheng CCV
Department:	Microbiology
Source(s) of Funding:	Commissioned Research on Control of Infectious Diseases (Phase III)
Start Date:	01/2015

Project Title:	Research Output Prize (Faculty of Medicine)
Investigator(s):	Yuen KY, Hung FNI, Zhang J, To KKW, Chan JFW, Chan TCI, Lau JY, Chen H, Chan KH
Department:	Microbiology
Source(s) of Funding:	Research Output Prize (in Faculty)
Start Date:	11/2016

Project Title:	Research and Development of a Rapid Diagnostics and Antiviral Targets
Investigator(s):	Yuen KY
Department:	Microbiology
Source(s) of Funding:	Respiratory Virus Research Foundation Limited
Start Date:	06/2017

List of Research Outputs

Researcher : Yuen KY

Project Title:	Establishment of core facilities for the HKU HIV/AIDS research laboratories
Investigator(s):	Yuen KY, Zheng B, Woo PCY, Yam WC, Im SWK
Department:	Microbiology
Source(s) of Funding:	Council for the AIDS Trust Fund - General Award
Start Date:	11/2001

Project Title:	Special Research Achievement Award 2003-2004
Investigator(s):	Yuen KY
Department:	Microbiology
Source(s) of Funding:	Special Research Achievement Award
Start Date:	11/2004

Project Title:	Bacteraemia caused by Anaerotruncus colihominis and emended description of the species
Investigator(s):	Yuen KY, Lau SKP, Woo PCY
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	09/2005

Project Title:	Investigation of invasive Lasiodiplodia theobromae infections in humans
Investigator(s):	Yuen KY, Tse H, Woo PCY, Lau SKP
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	09/2007

Project Title:	Molecular epidemiological investigation of PARV-4-related viruses in HK and southern China
Investigator(s):	Yuen KY, Tse H, Lau SKP, Woo PCY
Department:	Microbiology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	10/2008

Project Title:	Understanding the evolution and interspecies transmission of betacoronaviruses by structural and biophysical approaches
Investigator(s):	Yuen KY, Woo PCY, Lau SKP, Chan JFW
Department:	Microbiology
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2015

Project Title:	Control of viral and multidrug resistant bacterial infections relevant to Hong Kong SAR
Investigator(s):	Yuen KY, Jin D, Lau SKP, To KKW, Chan JFW, Sze KH, Tse H, Woo PCY, Hung FNI, Huang J, Ho PL, Kao RYT, Cheng CCV
Department:	Microbiology
Source(s) of Funding:	Commissioned Research on Control of Infectious Diseases (Phase III)
Start Date:	01/2015

Project Title:	Research Output Prize (Faculty of Medicine)
Investigator(s):	Yuen KY, Hung FNI, Zhang J, To KKW, Chan JFW, Chan TCI, Lau JY, Chen H, Chan KH
Department:	Microbiology
Source(s) of Funding:	Research Output Prize (in Faculty)
Start Date:	11/2016

Project Title:	Research and Development of a Rapid Diagnostics and Antiviral Targets
Investigator(s):	Yuen KY
Department:	Microbiology
Source(s) of Funding:	Respiratory Virus Research Foundation Limited
Start Date:	06/2017

List of Research Outputs

CHAUDHARY V., Yuen K.S., Chan J.F.W., Chan C.P., Kok K.H., Chan C.P., Yuen K.Y. and Jin D., Selective activation of interferon-γ signaling by Zika virus NS5 protein (invited speaker)., 2016 World Life Science Conference.. Beijing, China, 2016.

CHAUDHARY V., Yuen K.S., Chan J.F.W., Chan C.P., Wang F., Kok K.H., Chan C.P., Yuen K.Y. and Jin D., Zika virus NS5 protein differentially modulates type I and type II interferon signaling., Cross Street Immunology Conference, National Taiwan University, Taipei, March 18-19, 2017.. 2017.

CHEUNG N.N., Lai K.K., Dai J., Kok K.H., Chen H., Chan K.H., Yuen K.Y. and Kao R.Y.T., Broad-spectrum inhibition of common respiratory RNA viruses by a pyrimidine synthesis inhibitor with involvement of the host antiviral response. , Journal of General Virology. 2017.

Chan C.M., Chu H., Wang Y., Wong H.Y.B., Zhao X., Zhou J., Yang D., Leung A.S.P., Chan J.F.W., Yeung M.L., Yan J., Lu G., Gao G.F. and Yuen K.Y., Carcinoembryonic Antigen-related Cell Adhesion Molecule 5 (CEACAM5) Is an Important Surface Attachment Factor Facilitating the Entry of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV), Journal of Virology. 2016, JVI.01133-16.

Chan C.M., Chu H., Zhang J., Leung L.H., Sze K.H., Kao R.Y.T., Chik K.K.H., To K.K.W., Chan J.F.W., Chen H., Jin D., Liu L. and Yuen K.Y., Hemagglutinin of influenza A virus binds specifically to cell surface nucleolin and plays a role in virus internalization, Virology. 2016, 494: 78-88.

Chan J.F.W., Zhang J., Chan C.S., Yip C.Y., Mak W.N., Zhu H., Poon K.M., Tee K.M., Zhu Z., Cai J., Tsang O.L., Chik K.K.H., Yin F., Chan K.H., Kok K.H., Jin D., Au Yeung K.H.R. and Yuen K.Y., Characterization of a novel mouse model for Zika virus infection using dexamethasone-immunosuppressed mice, First International Conference on Zika Virus. 2017.

Chan J.F.W., Chan K.H., Yuan S., CHIK K.K.H., ZHU Z., Tee K.M., TSANG O.L., Yip C.Y., Poon K.M., Chan C.S., Mak W.N., Zhang J. and Yuen K.Y., Development of an in ovo system for evaluation of antivirals against Zika virus, 30th International Conference on Antiviral Research (ICAR). 2017.

Chan J.F.W., Yip C.Y., Tsang O.L., Tee K.M., Cai J., Chik K.K.H., Zhu Z., Chan C.S., CHOI K.Y., Sridhar S., Zhang J., Lu G., Chiu K., Lo A.C.Y., Tsao G.S.W., Kok K.H., Jin D., Chan K.H. and Yuen K.Y., Differential cell line susceptibility to the emerging Zika virus: implications for disease pathogenesis, non-vector-borne human transmission and animal reservoirs, Emerging Microbes & Infections. 2016, 5: e93.

Chan J.F.W., Choi G.K.Y., Leung S.S.M., Tee K.M., Tang S.F., Hung F.N.I. and Yuen K.Y., Epidemiological and clinical characteristics of patients with anti-interferon-gamma autoantibodies associated with opportunistic infections in Hong Kong, European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 2017.

Chan J.F.W., Choi G.K.Y., Leung S.S.M., Tee K.M., Tang S.F., Hung F.N.I. and Yuen K.Y., Epidemiology, Seroprevalence, and Clinical Manifestations of Immunodeficiency due to Autoantibody Against Interferon Gamma in Hong Kong, Health Research Symposium 2017 (Health and Medical Research Fund). 2017.

Chan J.F.W., Tee K.M., CHOI K.Y., Zhu Z., Poon W.S.R., Ng K.T.P., Chan K.H., Hung F.N.I., Man K. and Yuen K.Y., First detection and complete genome sequence of a phylogenetically distinct human polyomavirus 6 highly prevalent in human bile samples, Journal of Infection. 2017, 74: 50-59.

Chan J.F.W., CHIK K.K.H., Yuan S., Kao R.Y.T. and Yuen K.Y., Identification of bromocriptine as a Zika virus NS2B-NS3 protease inhibitor, American Society for Virology (ASV) 36th Annual Meeting. 2017.

Chan J.F.W., Yip C.Y., Tee K.M., Zhu Z., Tsang O.L., Chik K.K.H., TSANG G.W.T., Chan C.S., Poon K.M., Sridhar S., Yin F., Hung F.N.I., Chau S.K.Y., Zhang J., Chan K.H. and Yuen K.Y., Improved detection of Zika virus RNA in human and animal specimens by a novel, highly sensitive and specific real-time RT-PCR assay targeting the 5′-untranslated region of Zika virus, Tropical Medicine & International Health. 2017, 22: 594-603.

Chan J.F.W., CHIK K.K.H., Yuan S., Yip C.Y., ZHU Z., Tee K.M., TSANG O.L., Chan C.S., Poon K.M., Lu G., Zhang J., Lai K.K., Chan K.H., Kao R.Y.T. and Yuen K.Y., Novel antiviral activity and mechanism of bromocriptine as a Zika virus NS2B-NS3 protease inhibitor, Antiviral Research. 2017, 141: 29-37.

Chan J.F.W., Yip C.Y., Ho T.Y., Chan K.H., Hung F.N.I. and Yuen K.Y., Surveillance for Zika virus infection among asymptomatic returning travelers from the Rio Olympic and Paralymic Games, 33rd ASM Clinical Virology Symposium. 2017.

Chan J.F.W., Zhang J., Chan C.S., Yip C.Y., Mak W.N., Zhu H., Poon K.M., Tee K.M., Zhu Z., Cai J., Tsang O.L., Chik K.K.H., Yin F., Chan K.H., Kok K.H., Jin D., Au Yeung K.H.R. and Yuen K.Y., Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons, EBioMedicine. 2016, 14: 112-122.

Chaudhary V., Yuen K.S., Chan J.F.W., Chan C.P., Wang F., Cai J., Zhang S., Liang M., Kok K.H., Chan C.P., Yuen K.Y. and Jin D., Selective activation of type II interferon signaling by Zika virus NS5 protein, J Virol. 2017, 91(14): e00163-17.

Chen H.K.J., Lam H.Y., Yip C.Y., Wong S.C.Y., Chan J.F.W., Ma E.S., Cheng V.C.C., Tang S.F. and Yuen K.Y., Clinical Evaluation of the New High-Throughput Luminex NxTAG Respiratory Pathogen Panel Assay for Multiplex Respiratory Pathogen Detection, Journal of Clinical Microbiology. 2016, 54: 1820-1825.

Cheng C.C.V., Chen H.K.J., So S.Y.C., Wong C.Y.S., Chau P.H., Wong M.W.L., Ching H.C.R., Ng L.M.M., Lee W.M., Hung F.N.I., Ho P.L. and Yuen K.Y., A novel risk factor associated with colonization by Carbapenemase-Producing Enterobacteriaceae: Use of Proton Pump Inhibitors in addition to Antimicrobial Treatment, Infection Control & Hospital Epidemiology. 2016, 37: 1418-1425.

Cheng C.C.V., Wong S.C., Wong I.W.Y., Chau P.H., So S.Y.C., Wong C.Y.S., Chen H.K.J., Lee W.M., Tai J.W.M., Chau C.H., Lo W.K. and Yuen K.Y., The challenge of patient empowerment in hand hygiene promotion in health care facilities in Hong Kong, American Journal of Infection Control. 2017, 45: 562-565.

HUANG X., ZHENG M., Wang P., Mok B.W.Y., LIU S., Lau S.Y., CHEN P., Liu Y., LIU H., CHEN Y., Song W., Yuen K.Y. and Chen H., An NS-segment exonic splicing enhancer regulates influenza A virus replication in mammalian cells, Nature Communications. 2017, 8: 14751.

Hung F.N.I., To K.K.W., Chan J.F.W., Cheng C.C.V., Liu S.H.K., Tam A., Chan T.C.I., Zhang J., Li P.C.K., Wong T.L., ZHANG R., Cheung M.K.S., Leung W., Lau J.Y., Fok M., Chen H., Chan K.H. and Yuen K.Y., Efficacy of Clarithromycin-Naproxen-Oseltamivir Combination in the Treatment of Patients Hospitalized for Influenza A(H3N2) Infection: an open-label, randomized controlled, phase 2b/3 trial., Chest. 2017, 151: 1069-1080.

Hung F.N.I. and Yuen K.Y., Immunogenicity, safety and tolerability of intradermal influenza vaccines, Human Vaccines & Immunotherapeutics. 2017, 1-6.

Hung F.N.I., Zhang J., To K.K.W., Chan J.F.W., ZHU H., ZHANG R., Chan T.C.I., Chan K.H. and Yuen K.Y., Unexpectedly Higher Morbidity and Mortality of Hospitalized Elderly Patients Associated with Rhinovirus Compared with Influenza Virus Respiratory Tract Infection, International Journal of Molecular Sciences. 2017, 18: 259.

Jin D., CHAUDHARY V., Yuen K.S., Chan J.F.W., Chan C.P. and Yuen K.Y., Zika virus NS5 protein suppresses type I and type III interferon signaling but augments type II interferon signaling., The American Society for Virology 36th Annual Meeting, University of Wisconsin-Madison, Madison, Wisconsin, USA, June 23-28, 2017.. 2017.

LEUNG S.M., Lipsitch M., Yuen K.Y. and Wu J.T.K., Monitoring the fitness of antiviral-resistant influenza strains during an epidemic: a mathematical modelling study, The Lancet Infectious Diseases. 2016.

Lau S.K.P., Yeung C., Li K.S.M., Lam S.F., Cai J., Yuen M.C., Wang M., Zheng B., Woo P.C.Y. and Yuen K.Y., Identification and genomic characterization of a novel rat bocavirus from brown rats in China, Infection, Genetics and Evolution. 2017, 47: 68-76.

Lau S.K.P., Ahmed S.S., Yeung C., Li K.S.M., Fan Y.Y., Cheng T.Y., Cai J., Wang M., Zheng B., Wong S.S.Y., Woo P.C.Y. and Yuen K.Y., Identification and interspecies transmission of a novel bocaparvovirus among different bat species in China, The Journal of General Virology. 2016, 97: 3345-3358.

Lau S.K.P., Woo P.C.Y., Li K.S.M., Zhang H.J., Fan Y.Y., Zhang J., Chan B.C., Lam S.F., Yip C.Y., Yuen M.C., Chan K.H., Chen Z. and Yuen K.Y., Identification of Novel Rosavirus Species That Infects Diverse Rodent Species and Causes Multisystemic Dissemination in Mouse Model, PLoS Pathogen. 2016, 12: e1005911.

Lau S.K.P., Wernery R., Wong Y.M., Joseph S., Tsang K.L., Patteril N.A., Elizabeth S.K., Chan K.H., Muhammed R., Kinne J., Yuen K.Y., Wernery U. and Woo P.C.Y., Polyphyletic origin of MERS coronaviruses and isolation of a novel clade A strain from dromedary camels in the United Arab Emirates, Emerging Microbes and Infections. 2016, 5: e128.

Lee C.Y., To K.K.W., Zhu H., Chu H., Mak W.N., Zhang J. and Yuen K.Y., Avian influenza virus A H7N9 infects multiple mononuclear cell types in peripheral blood and induces dysregulated cytokine responses and apoptosis in infected monocytes, Journal of General Virology. 2017, 98: 922-934.

Sze K.H., Lam W.H., Zhang H., Ke Y., Tse M.K., Woo P.C.Y., Lau S.K.P., Lau C.Y., Cai J., Tung E.T., Lo R.K., Xu S., Kao R.Y.T., Hao Q. and Yuen K.Y., Talaromyces marneffei Mp1p Is a Virulence Factor that Binds and Sequesters a Key Proinflammatory Lipid to Dampen Host Innate Immune Response, Cell Chemical Biology. 2017, 24: 182-194.

Thu N.T.M., Chan J.F.W., Hien H.T.A., Tung N.L.N., Thanh N.T.T., Day J., Chau N.V.V., Thwaites G., Woo P.C.Y., Yuen K.Y. and Le T., Clinical Performance of the Mp1p Immunoassay for Rapid Diagnosis of Talaromyces marneffei Infection, Conference on Retroviruses and Opportunistic Infections. 2017.

To K.K.W., Lu L., Yip C.Y., Poon W.S.R., Fung A.M.Y., Cheng A., Lui D.H.K., Ho T.Y., Hung F.N.I., Chan K.H. and Yuen K.Y., Additional molecular testing of saliva specimens improves the detection of respiratory viruses, Emerging Microbes & Infections. 2017, 6: e49.

To K.K.W., Chan W.M., Li K.S.M., Lam S.F., Chen Z., Tse H., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., High prevalence of four novel astrovirus genotype species identified from rodents in China, Journal of General Virology. 2017, 98: 1004-1015.

To K.K.W., Lu L., Hung F.N.I. and Yuen K.Y., Host response of rhinovirus infection among hospitalized adult patients, American Society for Virology 36th Annual Meeting. 2017.

Wong S.C.Y., Tse H., Chen H.K.J., Cheng V.C.C., Ho P.L. and Yuen K.Y., Colistin-Resistant Enterobacteriaceae Carrying the mcr-1 Gene among Patients in Hong Kong , Emerging Infectious Diseases. 2016, 22: 1667-1669.

Woo P.C.Y., Wong Y.M., Wong B.H., Lam S.F., Fan Y.Y., Lau S.K.P. and Yuen K.Y., Comparative genome and evolutionary analysis of naturally occurring Beilong virus in brown and black rats., Infection, Genetics and Evolution. 2016, 45: 311-319.

Woo P.C.Y., Teng L.L., BAI R., Wong Y.P., Martelli P., Hui S.W., Tsang K.L., Lau C.Y., Ahmed S.S., Yip C.Y., CHOI K.Y., Li K.S.M., Lam S.F., Lau S.K.P. and Yuen K.Y., High Diversity of Genogroup I Picobirnaviruses in Mammals, Frontier in microbiology. 2016, 7: 1886.

Woo P.C.Y., Lau S.K.P., Choi G.K.Y., Hunag Y., Sivakumar S., Tsoi H.W., Yip C.C., Jose S.V., BAI R., Wong Y.M., Joesph M., Li T., Wernery U. and Yuen K.Y., Molecular epidemiology of canine picornavirus in Hong Kong and Dubai and proposal of a novel genus in Picornaviridae., Infect Genet Evol.. 2016, 41: 191-200.

Woo P.C.Y., Lau S.K.P., Lau C.Y., Tung T.K., Chong T.K., Yang F., Zhang H., Lo K.C., Cai J., Au Yeung K.H.R., Ng W.F., Tse H., Wong S.S.Y., Xu S., Lam W.H., Tse M.K., Sze K.H., Kao R.Y.T., Reiner N.E., Hao Q. and Yuen K.Y., Mp1p Is a Virulence Factor in Talaromyces (Penicillium) marneffei, PLOS Neglected Tropical Diseases. 2016, 10: e0004907.

Woo P.C.Y., Lau S.K.P., Teng L.L., Cao K.Y., Wernery U., Schountz T., Chiu T.H., Tsang K.L., Wong P.C., Wong Y.M. and Yuen K.Y., New Hepatitis E Virus Genotype in Bactrian Camels, Xinjiang, China, 2013, Emerging Infectious Diseases. 2016, 22: 2219-2221.

Woo P.C.Y., Lau S.K.P., Tsoi H.W., Patteril N.G., Yeung C., Joseph S., Wong Y.M., Muhammed R., Chow W.N., Wernery U. and Yuen K.Y., Two novel dromedary camel bocaparvoviruses from dromedaries in the Middle East with unique genomic features, The Journal of General Virology. 2017, 98: 1349-1359.

Woo P.C.Y., Lau S.K.P., Tsang C.C., Lau C.Y., Wong P.C., Chow W.N., Fong J.Y.H. and Yuen K.Y., Coronavirus HKU15 in respiratory tract of pigs and first discovery of coronavirus quasispecies in 5′-untranslated region, Emerging Microbes & Infections. 2017, 6: e53.

YANG K., Deng H., MAN W.C., SONG E., Zhang J., Luo C., Cheung B.M.Y., Yuen K.Y., Jensen P.S., Irmukhamedov A., Elie A...G...I...M., Vanhoutte P.M.G.R., Xu A., De Mey J.G.R. and Wang Y., Measuring non-polyaminated lipocalin-2 for cardiometabolic risk assessment, ESC Heart Failure. 2017, 1-13.

Ye Z., Yuan S., Poon K.M., Wen L.R., Yang D., Sun Z., Li C., Hu M., Shuai H., Zhou J., Zhang M., Zheng B., Chu H. and Yuen K.Y., Antibody-Dependent Cell-Mediated Cytotoxicity Epitopes on the Hemagglutinin Head Region of Pandemic H1N1 Influenza Virus Play Detrimental Roles in H1N1-Infected Mice, Frontiers in Immunology. Frontiers, 2017, 8: 317.

Yip C.Y., Tee K.M., Zhu Z., Chik K.K.H., Tsang O.L., Poon K.M., Chan C.S., Zhang J., Chan K.H., Yuen K.Y. and Chan J.F.W., Development and evaluation of a novel real-time RT-PCR assay targeting the envelope gene of the African and Asian/American lineages of the emerging Zika virus, 3rd Microbiology Asia Congress. 2016.

Yip C.Y., Lo J.Y.C., Sridhar S., Lung D.C., Luk S., Chan K.H., Chan J.F.W., Cheng C.C.V., Woo P.C.Y., Yuen K.Y. and Lau S.K.P., First Report of a Fatal Case Associated with EV-D68 Infection in Hong Kong and Emergence of an Interclade Recombinant in China Revealed by Genome Analysis, International Journal of Molecular Sciences. 2017, 18: e1065.

Yip C.Y., Tee K.M., ZHU Z., TSANG O.L., CHIK K.K.H., TSANG G.W.T., Chan C.S., Poon K.M., Sridhar S., Yin F., Hung F.N.I., Chau S.K.Y., Zhang J., Chan K.H., Yuen K.Y. and Chan J.F.W., Improved detection of Zika virus RNA in human and animal specimens by a novel, highly sensitive and specific real-time RT-PCR assay targeting the 5'-untranslated region of Zika virus, 33rd ASM Clinical Virology Symposium. 2017.

ZHANG B., Cai J., Yu B., HUA Y., Lau C.Y., Kao R.Y.T., Sze K.H., Yuen K.Y. and Huang J., A DNA vaccine targeting TcdA and TcdB induces protective immunity against Clostridium difficile, BMC Infectious Diseases. 2016, 16.

Zhao H., Chu H., Zhao X., SHUAI H., Wong H.Y.B., Wen L.R., Yuan S., Zheng B., Zhou J. and Yuen K.Y., Novel residues in the PA protein of avian influenza H7N7 virus affect virulence in mammalian hosts, Virology. 2016, 498: 1-8.

Researcher : ZHANG B

List of Research Outputs

ZHANG B., Cai J., Yu B., HUA Y., Lau C.Y., Kao R.Y.T., Sze K.H., Yuen K.Y. and Huang J., A DNA vaccine targeting TcdA and TcdB induces protective immunity against Clostridium difficile, BMC Infectious Diseases. 2016, 16.

Researcher : ZHU Z

List of Research Outputs

Chan J.F.W., Zhang J., Chan C.S., Yip C.Y., Mak W.N., Zhu H., Poon K.M., Tee K.M., Zhu Z., Cai J., Tsang O.L., Chik K.K.H., Yin F., Chan K.H., Kok K.H., Jin D., Au Yeung K.H.R. and Yuen K.Y., Characterization of a novel mouse model for Zika virus infection using dexamethasone-immunosuppressed mice, First International Conference on Zika Virus. 2017.

Chan J.F.W., Chan K.H., Yuan S., CHIK K.K.H., ZHU Z., Tee K.M., TSANG O.L., Yip C.Y., Poon K.M., Chan C.S., Mak W.N., Zhang J. and Yuen K.Y., Development of an in ovo system for evaluation of antivirals against Zika virus, 30th International Conference on Antiviral Research (ICAR). 2017.

Chan J.F.W., Yip C.Y., Tsang O.L., Tee K.M., Cai J., Chik K.K.H., Zhu Z., Chan C.S., CHOI K.Y., Sridhar S., Zhang J., Lu G., Chiu K., Lo A.C.Y., Tsao G.S.W., Kok K.H., Jin D., Chan K.H. and Yuen K.Y., Differential cell line susceptibility to the emerging Zika virus: implications for disease pathogenesis, non-vector-borne human transmission and animal reservoirs, Emerging Microbes & Infections. 2016, 5: e93.

Chan J.F.W., Tee K.M., CHOI K.Y., Zhu Z., Poon W.S.R., Ng K.T.P., Chan K.H., Hung F.N.I., Man K. and Yuen K.Y., First detection and complete genome sequence of a phylogenetically distinct human polyomavirus 6 highly prevalent in human bile samples, Journal of Infection. 2017, 74: 50-59.

Chan J.F.W., Yip C.Y., Tee K.M., Zhu Z., Tsang O.L., Chik K.K.H., TSANG G.W.T., Chan C.S., Poon K.M., Sridhar S., Yin F., Hung F.N.I., Chau S.K.Y., Zhang J., Chan K.H. and Yuen K.Y., Improved detection of Zika virus RNA in human and animal specimens by a novel, highly sensitive and specific real-time RT-PCR assay targeting the 5′-untranslated region of Zika virus, Tropical Medicine & International Health. 2017, 22: 594-603.

Chan J.F.W., CHIK K.K.H., Yuan S., Yip C.Y., ZHU Z., Tee K.M., TSANG O.L., Chan C.S., Poon K.M., Lu G., Zhang J., Lai K.K., Chan K.H., Kao R.Y.T. and Yuen K.Y., Novel antiviral activity and mechanism of bromocriptine as a Zika virus NS2B-NS3 protease inhibitor, Antiviral Research. 2017, 141: 29-37.

Chan J.F.W., Zhang J., Chan C.S., Yip C.Y., Mak W.N., Zhu H., Poon K.M., Tee K.M., Zhu Z., Cai J., Tsang O.L., Chik K.K.H., Yin F., Chan K.H., Kok K.H., Jin D., Au Yeung K.H.R. and Yuen K.Y., Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons, EBioMedicine. 2016, 14: 112-122.

Yip C.Y., Tee K.M., Zhu Z., Chik K.K.H., Tsang O.L., Poon K.M., Chan C.S., Zhang J., Chan K.H., Yuen K.Y. and Chan J.F.W., Development and evaluation of a novel real-time RT-PCR assay targeting the envelope gene of the African and Asian/American lineages of the emerging Zika virus, 3rd Microbiology Asia Congress. 2016.

Yip C.Y., Tee K.M., ZHU Z., TSANG O.L., CHIK K.K.H., TSANG G.W.T., Chan C.S., Poon K.M., Sridhar S., Yin F., Hung F.N.I., Chau S.K.Y., Zhang J., Chan K.H., Yuen K.Y. and Chan J.F.W., Improved detection of Zika virus RNA in human and animal specimens by a novel, highly sensitive and specific real-time RT-PCR assay targeting the 5'-untranslated region of Zika virus, 33rd ASM Clinical Virology Symposium. 2017.

Researcher : Zhang GH

List of Research Outputs

Verhoeven R.J.A., TONG S., Zhang G.H., Zong J.F., Chen Y.X., Jin D., Chen M.R., Pan J.J. and Chen H., NF-κB Signaling Regulates Expression of Epstein-Barr Virus BART MicroRNAs and Long Noncoding RNAs in Nasopharyngeal Carcinoma, Journal of Virology. USA, AMER SOC MICROBIOLOGY, 2016, 90: 6475-6488.

Researcher : Zhang H

Project Title:	the 1st european conference of microbiology and immunology Low Th17 expression association with Chronic Hepatitis B viral infection by means of reducing viral specific IFNγ releasing in a HBV infection model of IL-17 KO mice
Investigator(s):	Zhang H
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2011

Researcher : Zhang J

Project Title:	Modulation of prostaglandin E2 and lipoxins to ameliorate the severe lung inflammation induced by A(H1N1)pdm09 influenza virus in diet induced obese mice
Investigator(s):	Zhang J, To KKW, Zheng B
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2016

List of Research Outputs

Chan C.M., Chu H., Zhang J., Leung L.H., Sze K.H., Kao R.Y.T., Chik K.K.H., To K.K.W., Chan J.F.W., Chen H., Jin D., Liu L. and Yuen K.Y., Hemagglutinin of influenza A virus binds specifically to cell surface nucleolin and plays a role in virus internalization, Virology. 2016, 494: 78-88.

Chan J.F.W., Zhang J., Chan C.S., Yip C.Y., Mak W.N., Zhu H., Poon K.M., Tee K.M., Zhu Z., Cai J., Tsang O.L., Chik K.K.H., Yin F., Chan K.H., Kok K.H., Jin D., Au Yeung K.H.R. and Yuen K.Y., Characterization of a novel mouse model for Zika virus infection using dexamethasone-immunosuppressed mice, First International Conference on Zika Virus. 2017.

Chan J.F.W., Chan K.H., Yuan S., CHIK K.K.H., ZHU Z., Tee K.M., TSANG O.L., Yip C.Y., Poon K.M., Chan C.S., Mak W.N., Zhang J. and Yuen K.Y., Development of an in ovo system for evaluation of antivirals against Zika virus, 30th International Conference on Antiviral Research (ICAR). 2017.

Chan J.F.W., Yip C.Y., Tsang O.L., Tee K.M., Cai J., Chik K.K.H., Zhu Z., Chan C.S., CHOI K.Y., Sridhar S., Zhang J., Lu G., Chiu K., Lo A.C.Y., Tsao G.S.W., Kok K.H., Jin D., Chan K.H. and Yuen K.Y., Differential cell line susceptibility to the emerging Zika virus: implications for disease pathogenesis, non-vector-borne human transmission and animal reservoirs, Emerging Microbes & Infections. 2016, 5: e93.

Chan J.F.W., Yip C.Y., Tee K.M., Zhu Z., Tsang O.L., Chik K.K.H., TSANG G.W.T., Chan C.S., Poon K.M., Sridhar S., Yin F., Hung F.N.I., Chau S.K.Y., Zhang J., Chan K.H. and Yuen K.Y., Improved detection of Zika virus RNA in human and animal specimens by a novel, highly sensitive and specific real-time RT-PCR assay targeting the 5′-untranslated region of Zika virus, Tropical Medicine & International Health. 2017, 22: 594-603.

Chan J.F.W., CHIK K.K.H., Yuan S., Yip C.Y., ZHU Z., Tee K.M., TSANG O.L., Chan C.S., Poon K.M., Lu G., Zhang J., Lai K.K., Chan K.H., Kao R.Y.T. and Yuen K.Y., Novel antiviral activity and mechanism of bromocriptine as a Zika virus NS2B-NS3 protease inhibitor, Antiviral Research. 2017, 141: 29-37.

Chan J.F.W., Zhang J., Chan C.S., Yip C.Y., Mak W.N., Zhu H., Poon K.M., Tee K.M., Zhu Z., Cai J., Tsang O.L., Chik K.K.H., Yin F., Chan K.H., Kok K.H., Jin D., Au Yeung K.H.R. and Yuen K.Y., Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons, EBioMedicine. 2016, 14: 112-122.

Hung F.N.I., To K.K.W., Chan J.F.W., Cheng C.C.V., Liu S.H.K., Tam A., Chan T.C.I., Zhang J., Li P.C.K., Wong T.L., ZHANG R., Cheung M.K.S., Leung W., Lau J.Y., Fok M., Chen H., Chan K.H. and Yuen K.Y., Efficacy of Clarithromycin-Naproxen-Oseltamivir Combination in the Treatment of Patients Hospitalized for Influenza A(H3N2) Infection: an open-label, randomized controlled, phase 2b/3 trial., Chest. 2017, 151: 1069-1080.

Hung F.N.I., Zhang J., To K.K.W., Chan J.F.W., ZHU H., ZHANG R., Chan T.C.I., Chan K.H. and Yuen K.Y., Unexpectedly Higher Morbidity and Mortality of Hospitalized Elderly Patients Associated with Rhinovirus Compared with Influenza Virus Respiratory Tract Infection, International Journal of Molecular Sciences. 2017, 18: 259.

Lau S.K.P., Woo P.C.Y., Li K.S.M., Zhang H.J., Fan Y.Y., Zhang J., Chan B.C., Lam S.F., Yip C.Y., Yuen M.C., Chan K.H., Chen Z. and Yuen K.Y., Identification of Novel Rosavirus Species That Infects Diverse Rodent Species and Causes Multisystemic Dissemination in Mouse Model, PLoS Pathogen. 2016, 12: e1005911.

Lee C.Y., To K.K.W., Zhu H., Chu H., Mak W.N., Zhang J. and Yuen K.Y., Avian influenza virus A H7N9 infects multiple mononuclear cell types in peripheral blood and induces dysregulated cytokine responses and apoptosis in infected monocytes, Journal of General Virology. 2017, 98: 922-934.

Yip C.Y., Tee K.M., Zhu Z., Chik K.K.H., Tsang O.L., Poon K.M., Chan C.S., Zhang J., Chan K.H., Yuen K.Y. and Chan J.F.W., Development and evaluation of a novel real-time RT-PCR assay targeting the envelope gene of the African and Asian/American lineages of the emerging Zika virus, 3rd Microbiology Asia Congress. 2016.

Yip C.Y., Tee K.M., ZHU Z., TSANG O.L., CHIK K.K.H., TSANG G.W.T., Chan C.S., Poon K.M., Sridhar S., Yin F., Hung F.N.I., Chau S.K.Y., Zhang J., Chan K.H., Yuen K.Y. and Chan J.F.W., Improved detection of Zika virus RNA in human and animal specimens by a novel, highly sensitive and specific real-time RT-PCR assay targeting the 5'-untranslated region of Zika virus, 33rd ASM Clinical Virology Symposium. 2017.

Researcher : Zhang JX

Project Title:	Modulation of prostaglandin E2 and lipoxins to ameliorate the severe lung inflammation induced by A(H1N1)pdm09 influenza virus in diet induced obese mice
Investigator(s):	Zhang J, To KKW, Zheng B
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2016

List of Research Outputs

Researcher : Zhang K

List of Research Outputs

HU M., Chu H., Zhang K., SINGH K., Li C., Yuan S., Chow B.K.C., Song W., Zhou J. and Zheng B., Amino acid substitutions V63I or A37S/I61T/V63I/V100A in the PA N-terminal domain increase the virulence of H7N7 influenza A virus, Scientific Reports. ENGLAND, Nature Publishing Group, 2016, 6: 37800.

Yuan S., Chu H., Zhang K., Ye J., SINGH K., Kao R.Y.T., Chow B.K.C., Zhou J. and Zheng B., A novel small-molecule compound disrupts influenza A virus PB2 cap-binding and inhibits viral replication, Journal of Antimicrobial Chemotherapy. 2016, 71: 2489-2497.

Researcher : Zhang M

Project Title:	Development of a "Two-in-One" Duel Specific Antibody Therapeutics for Treatment of Breast Cancer
Investigator(s):	Zhang M
Department:	Microbiology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	11/2011

List of Research Outputs

Ye Z., Yuan S., Poon K.M., Wen L.R., Yang D., Sun Z., Li C., Hu M., Shuai H., Zhou J., Zhang M., Zheng B., Chu H. and Yuen K.Y., Antibody-Dependent Cell-Mediated Cytotoxicity Epitopes on the Hemagglutinin Head Region of Pandemic H1N1 Influenza Virus Play Detrimental Roles in H1N1-Infected Mice, Frontiers in Immunology. Frontiers, 2017, 8: 317.

Researcher : Zhao H

List of Research Outputs

Yuan S., Chu H., Ye J., SINGH K., Ye Z., Zhao H., Kao R.Y.T., Chow B.K.C., Zhou J. and Zheng B., Identification of a novel small-molecule compound targeting the influenza A virus polymerase PB1-PB2 interface, Antiviral Research. NETHERLANDS, ELSEVIER SCIENCE BV, 2016, 137: 58-66.

Zhao H., Chu H., Zhao X., SHUAI H., Wong H.Y.B., Wen L.R., Yuan S., Zheng B., Zhou J. and Yuen K.Y., Novel residues in the PA protein of avian influenza H7N7 virus affect virulence in mammalian hosts, Virology. 2016, 498: 1-8.

Researcher : Zhao X

List of Research Outputs

Chan C.M., Chu H., Wang Y., Wong H.Y.B., Zhao X., Zhou J., Yang D., Leung A.S.P., Chan J.F.W., Yeung M.L., Yan J., Lu G., Gao G.F. and Yuen K.Y., Carcinoembryonic Antigen-related Cell Adhesion Molecule 5 (CEACAM5) Is an Important Surface Attachment Factor Facilitating the Entry of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV), Journal of Virology. 2016, JVI.01133-16.

Zhao H., Chu H., Zhao X., SHUAI H., Wong H.Y.B., Wen L.R., Yuan S., Zheng B., Zhou J. and Yuen K.Y., Novel residues in the PA protein of avian influenza H7N7 virus affect virulence in mammalian hosts, Virology. 2016, 498: 1-8.

Researcher : Zheng B

Project Title:	Study of vaccine HA-M2 against H5N1 avian influenza virus
Investigator(s):	Zheng B
Department:	Microbiology
Source(s) of Funding:	Matching Fund for Hi-Tech Research and Development Program of China (863 Projects)
Start Date:	08/2007

Project Title:	Development of Antiviral Agents based on Small RNA Containing Unique Motif (UIM/215)
Investigator(s):	Zheng B, Zhou J
Department:	Microbiology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	05/2012

Project Title:	Development of Antiviral Peptides against Infections of Influenza Virus and Other Respiratory Viruses
Investigator(s):	Zheng B, Zhou J
Department:	Microbiology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	11/2013

Project Title:	Identification of ADCC epitopes on Hemagglutinin Antigen of Pandemic H1N1 Influenza Virus for Vaccine Development
Investigator(s):	Zheng B, Chu H
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2015

Project Title:	Development of Anti-influenza Agents Targeting Influenza Virus RNA Polymerase
Investigator(s):	Zheng B, Kao RYT, Zhou J
Department:	Microbiology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	09/2015

Project Title:	Development of Anti-influenza Agents Targeting Influenza Virus RNA Polymerase
Investigator(s):	Zheng B, Kao RYT, Zhou J
Department:	Microbiology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	09/2015

Project Title:	Development of Anti-influenza Agents Targeting Influenza Virus RNA Polymerase
Investigator(s):	Zheng B, Kao RYT, Zhou J
Department:	Microbiology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	09/2015

List of Research Outputs

HU M., Chu H., Zhang K., SINGH K., Li C., Yuan S., Chow B.K.C., Song W., Zhou J. and Zheng B., Amino acid substitutions V63I or A37S/I61T/V63I/V100A in the PA N-terminal domain increase the virulence of H7N7 influenza A virus, Scientific Reports. ENGLAND, Nature Publishing Group, 2016, 6: 37800.

Hu M., Yuan S., Ye Z., SINGH K., Li C., SHUAI H., Ng F., Chow B.K.C., Chu H. and Zheng B., PA N substitutions A37S, A37S/I61T and A37S/V63I attenuate the replication of H7N7 influenza A virus by impairing the polymerase and endonuclease activities, Journal of General Virology. 2017, 98: 364-373.

Lau S.K.P., Yeung C., Li K.S.M., Lam S.F., Cai J., Yuen M.C., Wang M., Zheng B., Woo P.C.Y. and Yuen K.Y., Identification and genomic characterization of a novel rat bocavirus from brown rats in China, Infection, Genetics and Evolution. 2017, 47: 68-76.

Lau S.K.P., Ahmed S.S., Yeung C., Li K.S.M., Fan Y.Y., Cheng T.Y., Cai J., Wang M., Zheng B., Wong S.S.Y., Woo P.C.Y. and Yuen K.Y., Identification and interspecies transmission of a novel bocaparvovirus among different bat species in China, The Journal of General Virology. 2016, 97: 3345-3358.

Ye Z., Yuan S., Poon K.M., Wen L.R., Yang D., Sun Z., Li C., Hu M., Shuai H., Zhou J., Zhang M., Zheng B., Chu H. and Yuen K.Y., Antibody-Dependent Cell-Mediated Cytotoxicity Epitopes on the Hemagglutinin Head Region of Pandemic H1N1 Influenza Virus Play Detrimental Roles in H1N1-Infected Mice, Frontiers in Immunology. Frontiers, 2017, 8: 317.

Yuan S. and Zheng B., A Novel Small-molecule Compound Disrupts Influenza A Virus PB2 Cap-binding and Inhibits Viral Replication , Options IX for the Control of Influenza. 2016.

Yuan S., Chu H., Zhang K., Ye J., SINGH K., Kao R.Y.T., Chow B.K.C., Zhou J. and Zheng B., A novel small-molecule compound disrupts influenza A virus PB2 cap-binding and inhibits viral replication, Journal of Antimicrobial Chemotherapy. 2016, 71: 2489-2497.

Yuan S., Chu H., Ye J., SINGH K., Ye Z., Zhao H., Kao R.Y.T., Chow B.K.C., Zhou J. and Zheng B., Identification of a novel small-molecule compound targeting the influenza A virus polymerase PB1-PB2 interface, Antiviral Research. NETHERLANDS, ELSEVIER SCIENCE BV, 2016, 137: 58-66.

Yuan S., Chu H., Ye J., Hu M., SINGH K., Chow B.K.C., Zhou J. and Zheng B., Peptide-Mediated Interference of PB2-eIF4G1 Interaction Inhibits Influenza A Viruses’ Replication in Vitro and in Vivo, ACS Infectious Diseases. 2016, 2: 471-477.

Zhao H., Chu H., Zhao X., SHUAI H., Wong H.Y.B., Wen L.R., Yuan S., Zheng B., Zhou J. and Yuen K.Y., Novel residues in the PA protein of avian influenza H7N7 virus affect virulence in mammalian hosts, Virology. 2016, 498: 1-8.

Researcher : Zheng B.

Project Title:	Study of vaccine HA-M2 against H5N1 avian influenza virus
Investigator(s):	Zheng B
Department:	Microbiology
Source(s) of Funding:	Matching Fund for Hi-Tech Research and Development Program of China (863 Projects)
Start Date:	08/2007

Project Title:	Development of Antiviral Agents based on Small RNA Containing Unique Motif (UIM/215)
Investigator(s):	Zheng B, Zhou J
Department:	Microbiology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	05/2012

Project Title:	Development of Antiviral Peptides against Infections of Influenza Virus and Other Respiratory Viruses
Investigator(s):	Zheng B, Zhou J
Department:	Microbiology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	11/2013

Project Title:	Identification of ADCC epitopes on Hemagglutinin Antigen of Pandemic H1N1 Influenza Virus for Vaccine Development
Investigator(s):	Zheng B, Chu H
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2015

Project Title:	Development of Anti-influenza Agents Targeting Influenza Virus RNA Polymerase
Investigator(s):	Zheng B, Kao RYT, Zhou J
Department:	Microbiology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	09/2015

Project Title:	Development of Anti-influenza Agents Targeting Influenza Virus RNA Polymerase
Investigator(s):	Zheng B, Kao RYT, Zhou J
Department:	Microbiology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	09/2015

Project Title:	Development of Anti-influenza Agents Targeting Influenza Virus RNA Polymerase
Investigator(s):	Zheng B, Kao RYT, Zhou J
Department:	Microbiology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	09/2015

List of Research Outputs

Researcher : Zheng M

Project Title:	Options IX for the Control of Influenza Conference; Characterization of the role of the nuclear export protein (NEP) of influenza A virus in M gene splicing
Investigator(s):	Zheng M
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2016
Completion Date:	08/2016

List of Research Outputs

HUANG X., ZHENG M., Wang P., Mok B.W.Y., LIU S., Lau S.Y., CHEN P., Liu Y., LIU H., CHEN Y., Song W., Yuen K.Y. and Chen H., An NS-segment exonic splicing enhancer regulates influenza A virus replication in mammalian cells, Nature Communications. 2017, 8: 14751.

Zheng M., Wang P., Lau S.Y., HUANG X., Mok B.W.Y., LIU S., LIU H., Liu Y. and Chen H., Characterization of mutations associated with cold adapted properties in DelNS1 influenza viruses; potential for new live attenuated influenza vaccine development , Options IX for The Control of Influenza, Chicago, USA, 24-28 Aug, 2016.

Researcher : Zhou J

Project Title:	A cell-based model to uncover the molecular underpinning of differential susceptibility and variable severity of human H7N9 influenza infection
Investigator(s):	Zhou J, Song Y, To KKW
Department:	Microbiology
Source(s) of Funding:	Commissioned Studies on Emerging Influenza A Viruses with Epidemic Potential
Start Date:	08/2014

Project Title:	Characterization of the immune activation pathway in human macrophage and the macrophage-neutrophil interaction in MERS coronavirus infection
Investigator(s):	Zhou J, Jin D, Chan JFW
Department:	Microbiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2015

List of Research Outputs

Chan C.M., Chu H., Wang Y., Wong H.Y.B., Zhao X., Zhou J., Yang D., Leung A.S.P., Chan J.F.W., Yeung M.L., Yan J., Lu G., Gao G.F. and Yuen K.Y., Carcinoembryonic Antigen-related Cell Adhesion Molecule 5 (CEACAM5) Is an Important Surface Attachment Factor Facilitating the Entry of the Middle East Respiratory Syndrome Coronavirus (MERS-CoV), Journal of Virology. 2016, JVI.01133-16.

Deng J., Kong K.Y., Gao W., Tang H.M.V., CHAUDHARY V., CHENG Y., Zhou J., Chan C.P., Wong D.K.H., Yuen R.M.F. and Jin D., Interplay between SIRT1 and hepatitis B virus X protein in the activation of viral transcription, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 2017, 1860: 491-501.

HU M., Chu H., Zhang K., SINGH K., Li C., Yuan S., Chow B.K.C., Song W., Zhou J. and Zheng B., Amino acid substitutions V63I or A37S/I61T/V63I/V100A in the PA N-terminal domain increase the virulence of H7N7 influenza A virus, Scientific Reports. ENGLAND, Nature Publishing Group, 2016, 6: 37800.

Ye Z., Yuan S., Poon K.M., Wen L.R., Yang D., Sun Z., Li C., Hu M., Shuai H., Zhou J., Zhang M., Zheng B., Chu H. and Yuen K.Y., Antibody-Dependent Cell-Mediated Cytotoxicity Epitopes on the Hemagglutinin Head Region of Pandemic H1N1 Influenza Virus Play Detrimental Roles in H1N1-Infected Mice, Frontiers in Immunology. Frontiers, 2017, 8: 317.

Yuan S., Chu H., Zhang K., Ye J., SINGH K., Kao R.Y.T., Chow B.K.C., Zhou J. and Zheng B., A novel small-molecule compound disrupts influenza A virus PB2 cap-binding and inhibits viral replication, Journal of Antimicrobial Chemotherapy. 2016, 71: 2489-2497.

Yuan S., Chu H., Ye J., SINGH K., Ye Z., Zhao H., Kao R.Y.T., Chow B.K.C., Zhou J. and Zheng B., Identification of a novel small-molecule compound targeting the influenza A virus polymerase PB1-PB2 interface, Antiviral Research. NETHERLANDS, ELSEVIER SCIENCE BV, 2016, 137: 58-66.

Yuan S., Chu H., Ye J., Hu M., SINGH K., Chow B.K.C., Zhou J. and Zheng B., Peptide-Mediated Interference of PB2-eIF4G1 Interaction Inhibits Influenza A Viruses’ Replication in Vitro and in Vivo, ACS Infectious Diseases. 2016, 2: 471-477.

Zhao H., Chu H., Zhao X., SHUAI H., Wong H.Y.B., Wen L.R., Yuan S., Zheng B., Zhou J. and Yuen K.Y., Novel residues in the PA protein of avian influenza H7N7 virus affect virulence in mammalian hosts, Virology. 2016, 498: 1-8.

Researcher : Zhu H

Project Title:	Molecular basis for the infectivity and transmissibility of the human isolated A(H7N9) influenza virus in a ferret model
Investigator(s):	Zhu H, Guan Y
Department:	School of Public Health
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2014

Project Title:	Research Output Prize (Li Ka Shing Faculty of Medicine)
Investigator(s):	Zhu H
Department:	School of Public Health
Source(s) of Funding:	Research Output Prize (in Faculty)
Start Date:	12/2014

Project Title:	Molecular determinants for the interspecies transmission of an avian H6N1 virus that caused the human infection in Taiwan
Investigator(s):	Zhu H, Guan Y
Department:	School of Public Health
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2015

Project Title:	Continuous evolution of H10N8 influenza viruses in chickens and molecular determinants for their infectivity in mammals
Investigator(s):	Zhu H, Guan Y, Lam TY
Department:	School of Public Health
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2015

Project Title:	Outstanding Young Researcher Award 2015-16
Investigator(s):	Zhu H
Department:	School of Public Health
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	11/2016

List of Research Outputs

Chan J.F.W., Zhang J., Chan C.S., Yip C.Y., Mak W.N., Zhu H., Poon K.M., Tee K.M., Zhu Z., Cai J., Tsang O.L., Chik K.K.H., Yin F., Chan K.H., Kok K.H., Jin D., Au Yeung K.H.R. and Yuen K.Y., Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons, EBioMedicine. 2016, 14: 112-122.

Cheung Y.M., Lam T.Y., Zhu H. and Guan Y., Evolution and spatial dissemination of the highly pathogenic Asian H5 avian influenza viruses., Virus Evol. . 2017, 3(Suppl 1): pii: vew036.041.

Li L., Hong W., Duan L., Wang J., Lam T.Y., Zhu H. and Guan Y., Evolution of influenza A(H7N9) viruses from waves I to IV, Virus Evol.. 2017, 3(Suppl 1): pii: vew036.006.

Researcher : Zhu Z

List of Research Outputs

Chan J.F.W., Zhang J., Chan C.S., Yip C.Y., Mak W.N., Zhu H., Poon K.M., Tee K.M., Zhu Z., Cai J., Tsang O.L., Chik K.K.H., Yin F., Chan K.H., Kok K.H., Jin D., Au Yeung K.H.R. and Yuen K.Y., Zika Virus Infection in Dexamethasone-immunosuppressed Mice Demonstrating Disseminated Infection with Multi-organ Involvement Including Orchitis Effectively Treated by Recombinant Type I Interferons, EBioMedicine. 2016, 14: 112-122.

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