| THE
UNIVERSITY OF HONG KONG |
DEPARTMENT OF ZOOLOGY
| Researcher : Au WL |
| List of Research Outputs |
| Ip C.Y., Lau S.L.J., Au W.L. and Leung F.C.C., Characterization of the 5'-flanking transcriptional regulatory region of the chicken growth hormone gene , Biotechnology, Agronomy Society and Environment. 2004, 8 (Sp. Issue): 36. |
| Researcher : Au YK |
| List of Research Outputs |
| Au Y.K., Ravni A., Eiden L., Chow B.K.C., Gonzalez B., Vaudry H. and Vaudry D., NGF and PACAP highly up-regulate the expression of serpin in PC12 cells through activation of Calcineurin AND MEK pathways, 11th Meeting of the European Neuroendocrine Association, Sorrento, Italy. 2004. |
| Researcher : Bao J |
| List of Research Outputs |
| Bao J., Sun M., Zhu L. and Corke H., Analysis of quantitative trait loci for some starch properties of rice (Oryza sativa L.): thermal properties, gel texture and swelling volume, Journal of Cereal Science. 2004, 39: 379-385. |
| Bao J., Sun M. and Corke H., Genetic diversity of starch physicochemical properties of waxy rice (Oryza sativa L.), Journal of the Science of Food and Agriculture. 2004, 84: 1299-1306. |
| Bao J. and Corke H., Rice: genetics, In: "Encyclopedia of Grain Science",(C.W. Wrigley, H. Corke and C.E. Walker, eds.). Oxford, Elsevier, 2004, Vol. 3: Pages 48-61. |
| Researcher : Chan DKO |
| Project Title: | Food processing for fermented products |
| Investigator(s): | Prof. Chan D.K.O. |
| Department: | Zoology |
| Source(s) of Funding: | Miscellaneous external fund sources |
| Start Date: | 07/1996 |
| Abstract: |
| To modernize fermentation processes for soy fermentation products. |
| List of Research Outputs |
| Yeung H.Y., Chan D.K.O., Mak N.K., Wagner G.F. and Wong C.K.C., Identification of Signal Transduction Pathways that Modulate Dibutyryl Cyclic Adenosine Monophosphate Activation of Stanniocalcin Gene Expression in Neuroblastoma Cells, Endocrinology. 2003, 144: 4446-4452. |
| Researcher : Chan MN |
| List of Research Outputs |
| Guan Y., Peiris J.S.M., Zheng B., Poon L.L.M., Chan K.H., Zeng F., Chan W.M., Chan M.N., Chen J., Chow Y.C.K., Hon C.C., Hui K.H., Li J., Li Y.Y., Wang Y., Leung C.S.W., Yuen K.Y. and Leung F.C.C., Molecular epidemiology of the novel coronavirus that causes severe acute respiratory syndrome, The Lancet. 2004, 363: 99-104. |
| Hui K.H., Zeng F., Chan M.N., Yuen K.Y., Peiris J.S.M. and Leung F.C.C., RT-PCR Diagnosis of Coronavirus Associated with Severe Acute Respiratory Syndrome (SARS), Journal Clinical Microbiology. 2004, 42: 1994-1999. |
| Zeng F., Chan W.M., Chan M.N., Chen J., Chow Y.C.K., Hon C.C., Hui K.H., Li J., Li Y.Y., Wang Y., Wang Y., Guan Y., Zheng B., Poon L.L.M., Chan K.H., Yuen K.Y., Peiris J.S.M. and Leung F.C.C., The Complete Genome Sequence of Severe Acute Respiratory Syndrome Coronavirus Strain HKU-39849 (HK-39), Experimental Biology Medicine. 2003, 228: 866-873. |
| Researcher : Chan SM |
| Project Title: | The role of 5 HT and 5 HT receptors in the regulation of shrimp neurohormone gene expression: potential application in shrimp aquaclture |
| Investigator(s): | Dr. Chan S.M. |
| Department: | Zoology |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | 11/2001 |
| Abstract: |
| To study molecular characterization of the serotonin receptor genes; to study expression of serotonin receptors in shrimp; to study the effect of serotonin on the expression and synthesis of the eyestalk CHH/MIH/GIH neurohormone. |
| Project Title: | Analysis of the shrimp vitellogenin gene |
| Investigator(s): | Dr. Chan S.M. |
| Department: | Zoology |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 11/2001 |
| Completion Date: | 10/2003 |
| Abstract: |
| To characterize a 170 kDa polypeptide that show significant increase and positive correlation with the female gonad maturation cycle. |
| Project Title: | Vitellogenesis in the decapod crustacean: analysis of the shrimp vitellogenin gene and the hormonal control of shrimp vitellogenesis |
| Investigator(s): | Dr. Chan S.M. |
| Department: | Zoology |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | 09/2002 |
| Abstract: |
| The project attempts to: 1) characterize the shrimp vitelogenin; 2) clone the vitellogenin gene and cDNA; 3) study the expression of shrimp vitellogenin; and 4) study the hormonal effects of vitellogenesis. |
| Project Title: | The role of the GATA transcription factor in the regulation of the shrimp eyestalk crustacean hyperglycemic hormone A (CHH-A) and vitellogenin gene expression |
| Investigator(s): | Dr. Chan S.M. |
| Department: | Zoology |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | 09/2003 |
| Abstract: |
| To clone and characterize the GATA-TF from the shrimp; to analyze the expression of the GATA-TF in relation to the reproductive cycle; to investigate the role of GATA-TF in the regulation of CHH-A gene and vitellogenin gene. |
| Project Title: | The role of the GATA transcription factor in the regulation of the shrimp eyestalk crustacean hyperglycemic hormone A (CHH-A) and vitellogenin gene expression |
| Investigator(s): | Dr. Chan S.M. |
| Department: | Zoology |
| Source(s) of Funding: | RGC Projects (Block Grant Funded) |
| Start Date: | 09/2003 |
| Abstract: |
| To clone and characterize the GATA-TF from the shrimp; to analyze the expression of the GATA-TF in relation to the reproductive cycle; to investigate the role of GATA-TF in the regulation of CHH-A gene and vitellogenin gene. |
| List of Research Outputs |
| Chan S.M., Gu P., Chu K.H. and Tobe S.S., Crustacean neuropeptide genes of the CHH/MIH/GIH family: implications from molecular studies, Endocrinology. 2003, 134: 214-219. |
| Gunawardene Y.I.N.S., Bendena W.G., Tobe S.S. and Chan S.M., Comparative immunohistochemistry and cellular distribution of farnesoic acid Omethyltransferase in the shrimp and the crayfish, Peptides. 2003, 24: 1591-1597. |
| Yin Z.X., He J.G., Deng W.X. and Chan S.M., Molecular cloning, expression of orange-spotted grouper goose-type Iysozyme cDNA, and lytic activity of its recombinant protein, Diseases of Aquatic Organisms. 2003, 55: 117-123. |
| Researcher : Chan STH |
| List of Research Outputs |
| Xu J., Chan S.T.H., Ho P.C. and Yeung W.S.B., Coculture of human oviductal cells maintains mitochondrial function and decreases caspase activity of cleavage-stage mouse embryos, Fertility and Sterility. 2003, 80(1): 178-183. |
| Researcher : Chan WM |
| List of Research Outputs |
| Guan Y., Peiris J.S.M., Zheng B., Poon L.L.M., Chan K.H., Zeng F., Chan W.M., Chan M.N., Chen J., Chow Y.C.K., Hon C.C., Hui K.H., Li J., Li Y.Y., Wang Y., Leung C.S.W., Yuen K.Y. and Leung F.C.C., Molecular epidemiology of the novel coronavirus that causes severe acute respiratory syndrome, The Lancet. 2004, 363: 99-104. |
| Zeng F., Chan W.M., Chan M.N., Chen J., Chow Y.C.K., Hon C.C., Hui K.H., Li J., Li Y.Y., Wang Y., Wang Y., Guan Y., Zheng B., Poon L.L.M., Chan K.H., Yuen K.Y., Peiris J.S.M. and Leung F.C.C., The Complete Genome Sequence of Severe Acute Respiratory Syndrome Coronavirus Strain HKU-39849 (HK-39), Experimental Biology Medicine. 2003, 228: 866-873. |
| Researcher : Chan YM |
| List of Research Outputs |
| Chan Y.M. and Lim B.L., Interaction of a Putative Transcriptional Regulatory Protein and the Thermo-inducible cts-52 Mutant Repressor in the Bacillus subtilis Phage f105 Genome , Journal of Molecular Biology. 2003, 333: 21-31. |
| Researcher : Chen J |
| List of Research Outputs |
| Guan Y., Peiris J.S.M., Zheng B., Poon L.L.M., Chan K.H., Zeng F., Chan W.M., Chan M.N., Chen J., Chow Y.C.K., Hon C.C., Hui K.H., Li J., Li Y.Y., Wang Y., Leung C.S.W., Yuen K.Y. and Leung F.C.C., Molecular epidemiology of the novel coronavirus that causes severe acute respiratory syndrome, The Lancet. 2004, 363: 99-104. |
| Wu H., Chen J. and Leung F.C.C., Chicken Infectious Diseases Virus Recombinant DNA Constructs and its Efficacy in Special Pathogen Free Chickens, Journal of Animal and Veterinary Advances. 2003, 2: 448-451. |
| Zeng F., Chan W.M., Chan M.N., Chen J., Chow Y.C.K., Hon C.C., Hui K.H., Li J., Li Y.Y., Wang Y., Wang Y., Guan Y., Zheng B., Poon L.L.M., Chan K.H., Yuen K.Y., Peiris J.S.M. and Leung F.C.C., The Complete Genome Sequence of Severe Acute Respiratory Syndrome Coronavirus Strain HKU-39849 (HK-39), Experimental Biology Medicine. 2003, 228: 866-873. |
| Researcher : Cheng CK |
| List of Research Outputs |
| Cheng C.K., Chow B.K.C. and Leung P.C.K., An Activator Protein 1-Like Motif Mediates 17b-Estradiol Repression of Gonadotropin-Releasing Hormone Receptor Promoter via an Estrogen Receptor a-Dependent Mechanism in Ovarian and Breast Cancer Cells , Molecular Endocrinology. 2004, 17: 2613-2629. |
| Cheng C.K., Hoo L.C.R., Chow B.K.C. and Leung P.C.K., Functional Cooperation between Multiple Regulatory Elements in the Untranslated Exon 1 Stimulates the Basal Transcription of the Human GnRH-II Gene, Molecular Endocrinology. 2003, 17: 1175-1191. |
| Researcher : Cheng CW |
| List of Research Outputs |
| Yip W.K., Wang L.J., Cheng C.W., Wu W.L., Lung S.C. and Lim B.L., The Introduction of a phytase gene from Bacillus subtilis improved the growth performance of transgenic tobacco, Biochemical and Biophysical Research Communications. 2003, 310: 1148-1154. |
| Researcher : Cheung HK |
| List of Research Outputs |
| Cheung H.K., Mei J., Wang T. and Xu R.J., Detection and Characterization of Soluble Betaglycan in Porcine Milk, Journal of Animal and Veterinary Advances. 2004, 3: 278-284. |
| Cheung H.K., Mei J. and Xu R.J., Quantification of soluble betaglycan in porcine milk, Asia Pacific Journal of Clinical Nutrition . 2003, 12 (Suppl.): S61. |
| Researcher : Chow BKC |
| Project Title: | Secretin as a neuropeptide |
| Investigator(s): | Dr. Chow B.K.C., Dr. Yung W.H. |
| Department: | Zoology |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 11/2001 |
| Completion Date: | 10/2003 |
| Abstract: |
| To study the distribution of rat secretin and secretin receptor in various regions of the rat brain by Reverse transcript-polymerase chain reaction (RT-PCR), Northern blot analysis, in situ hybridization and immunocytochemical staining; to investigate the electrophysiological functions of secretin in regulating purkinje cell functions, particularly on neuronal pathways and mechanisms. |
| Project Title: | Functional and structural evolution of VIP and PACAP receptors in vertebrates |
| Investigator(s): | Dr. Chow B.K.C., Prof. Vaudry H. |
| Department: | Zoology |
| Source(s) of Funding: | France/Hong Kong Joint Research Scheme |
| Start Date: | 01/2002 |
| Completion Date: | 12/2003 |
| Abstract: |
| To understand the process of co-evolution of the PACAP/VIP family of peptides and their cognate receptors, and to search for novel members of peptides and receptors for this family in vertebrates including mammals. |
| Project Title: | Secretin as a neuropeptide |
| Investigator(s): | Dr. Chow B.K.C., Dr. Yung W.H. |
| Department: | Zoology |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | 09/2002 |
| Abstract: |
| The project attempts to:- 1) study the distributions fo secretin and secretin receptor in the rat brain by in situ hybridization and immunocytochemical staining; 2) investigate the electrophysiological functions of secretin in regulating Purkinje cell functions, particularly on neuronal pathways and mechanisms; and 3) study the potential electrophysiological activities of secretin in discrete cells from other brain regions. |
| Project Title: | Regulation of the human secretin receptor gene |
| Investigator(s): | Dr. Chow B.K.C. |
| Department: | Zoology |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 11/2003 |
| Abstract: |
| To investigate the interactions of GC motifs within the core promoter region of the hSR gene with Sp1 and Sp3. In addition, the connections between the Sp proteins, cytosine methylation and methylation imprinting will also be studied to elucidate the epigenetic regulation of expression in the hSR gene. |
| List of Research Outputs |
| Au Y.K., Ravni A., Eiden L., Chow B.K.C., Gonzalez B., Vaudry H. and Vaudry D., NGF and PACAP highly up-regulate the expression of serpin in PC12 cells through activation of Calcineurin AND MEK pathways, 11th Meeting of the European Neuroendocrine Association, Sorrento, Italy. 2004. |
| Cheng C.K., Chow B.K.C. and Leung P.C.K., An Activator Protein 1-Like Motif Mediates 17b-Estradiol Repression of Gonadotropin-Releasing Hormone Receptor Promoter via an Estrogen Receptor a-Dependent Mechanism in Ovarian and Breast Cancer Cells , Molecular Endocrinology. 2004, 17: 2613-2629. |
| Cheng C.K., Hoo L.C.R., Chow B.K.C. and Leung P.C.K., Functional Cooperation between Multiple Regulatory Elements in the Untranslated Exon 1 Stimulates the Basal Transcription of the Human GnRH-II Gene, Molecular Endocrinology. 2003, 17: 1175-1191. |
| Chiu J.Y.S., Alexandre D., Chow B.K.C., Vaudry H. and Anouar Y., Charactérisation moléculaire d'un nouveau variant du récepteur du neuropeptide PACAP dans le cerveau de la grenouille, 6e Colloque de la, Société des Neurosciences, Rouen, 13-16 mai. 2003. |
| Chow B.K.C., Moon T.W., Hoo L.C.R., Yeung C.M., Muller M., Christos P.J. and Mojsov S., Identification and Characterization of a Glucagon Receptor from the Goldfish Carassius auratus: Implications for the Evolution of the Ligand Specificity of Glucagon Receptors in Vertebrates , Endocrinology. 2004, 145: 3273-3288. |
| Chow B.K.C., Cheung K.H., Tsang E.M.W., Leung M.C.T., Lee M.Y. and Wong P.Y.D., Secretin Controls Anion Secretion in the Rat Epididymis in an Autocrine/Paracrine Fashion, Biology of Reproduction. 2004, 70: 1594-1599. |
| Chu Y.S.J., Lee M.Y., Yung W.H. and Chow B.K.C., Localization and the release mechanism of secretin in hypothalamo-pituitary system of the Wistar Rat Rattus novegicus, 11th Meeting of the European Neuroendocrine Association, Sorrento, Italy. 2004. |
| Kwok Y.Y., Chu Y.S.J., Anouar Y., Tse L.Y. and Chow B.K.C., Cloning and characterizing PAC1 receptor-Hop1 splice variant in goldfish (Carrasius auratus), 11th Meeting of the European Neuroendocrine Association, Sorrento, Italy. 2004. |
| Lee M.Y., Yung W.H., Ng S.M., Chen L. and Chow B.K.C., Electrophysiological effects and release characteristics in the rat cerebellum, 6th IBRO World congress of Neuroscience, Prague, Czech Republic. 2003. |
| Lee T.O., Lee M.Y., Tan-Un K.C. and Chow B.K.C., Expression Regulation of the Secretin gene in Human Neuroblastoma cells throughout Retinoic acid induced Neuronal differentiation, 6th IBRO World congress of Neuroscience, Prague, Czech Republic. 2003. |
| Lee T.O., Tan-Un K.C., Pang R.T.K., Lam D.T.W. and Chow B.K.C., Regulation of the Human Secretin Gene is Controlled by the Combined Effects of CpG Methylation, Sp1/Sp3 Ratio, and the E-Box Element , Molecular Endocrinology. 2004, 18: 1740-1755. |
| Pang T.K.R., Lee T.O., Ng S.M., Yung W.H. and Chow B.K.C., CpG Methylation and Transcription Factors Sp1 and Sp3 Regulate the Expression of the Human Secretin Receptor Gene, Molecular Endocrinology. 2004, 18: 471-483. |
| Siu K.Y., Sham M.H., Ng S.M. and Chow B.K.C., The Expression of Secretin in the Mouse Embryonic Development, 6th IBRO World congress of Neuroscience, Prague, Czech Republic. 2003. |
| Researcher : Chow YCK |
| List of Research Outputs |
| Chan P.K.S., Tam J.S., Sung J.J.Y., Zeng F., Chow Y.C.K. and Leung F.C.C., Estimated Timing of the Last Common Ancestor of the SARS Coronavirus, New England Journal of Medicine. 2003, 349: 2469-2470. |
| Chow Y.C.K., Hon C.C., Hui K.H., Wong T.Y., Yip C.W., Zeng F. and Leung F.C.C., Molecular Advances in Severe Acute Respiratory Syndrome-associated Coronavirus (SARS-CoV), Genomics, Proteomics and Bioinformatics. 2003, 1: 247-262. |
| Guan Y., Peiris J.S.M., Zheng B., Poon L.L.M., Chan K.H., Zeng F., Chan W.M., Chan M.N., Chen J., Chow Y.C.K., Hon C.C., Hui K.H., Li J., Li Y.Y., Wang Y., Leung C.S.W., Yuen K.Y. and Leung F.C.C., Molecular epidemiology of the novel coronavirus that causes severe acute respiratory syndrome, The Lancet. 2004, 363: 99-104. |
| Hon C.C., Chow Y.C.K., Zeng F. and Leung F.C.C., Genetic Authentication of Ginseng and Other Traditional Chinese Medicine, Acta Pharmacologica Sinica. 2003, 24: 841-846. |
| Zeng F., Chow Y.C.K., Hon C.C., Law K.M., Yip C.W., Chan K.H., Peiris J.S.M. and Leung F.C.C., Characterization of humoral responses in mice immunized with plasmid DNAs encoding SARS-CoV spike gene fragments, Biochemical and Biophysical Research Communications. 2004, 315: 1134-1139. |
| Zeng F., Hon C.C., Chow Y.C.K. and Leung F.C.C., Standardization of TCM by Genetic and Functional Authentication, Medicine in the 21st Century Tri-Conference & Bio-Forum, July 24th to 27th 2004, Shanghai, China. 2004. |
| Zeng F., Chan W.M., Chan M.N., Chen J., Chow Y.C.K., Hon C.C., Hui K.H., Li J., Li Y.Y., Wang Y., Wang Y., Guan Y., Zheng B., Poon L.L.M., Chan K.H., Yuen K.Y., Peiris J.S.M. and Leung F.C.C., The Complete Genome Sequence of Severe Acute Respiratory Syndrome Coronavirus Strain HKU-39849 (HK-39), Experimental Biology Medicine. 2003, 228: 866-873. |
| Researcher : Chu YSJ |
| List of Research Outputs |
| Chu Y.S.J., Lee M.Y., Yung W.H. and Chow B.K.C., Localization and the release mechanism of secretin in hypothalamo-pituitary system of the Wistar Rat Rattus novegicus, 11th Meeting of the European Neuroendocrine Association, Sorrento, Italy. 2004. |
| Kwok Y.Y., Chu Y.S.J., Anouar Y., Tse L.Y. and Chow B.K.C., Cloning and characterizing PAC1 receptor-Hop1 splice variant in goldfish (Carrasius auratus), 11th Meeting of the European Neuroendocrine Association, Sorrento, Italy. 2004. |
| Researcher : Gu P |
| List of Research Outputs |
| Chan S.M., Gu P., Chu K.H. and Tobe S.S., Crustacean neuropeptide genes of the CHH/MIH/GIH family: implications from molecular studies, Endocrinology. 2003, 134: 214-219. |
| Researcher : Gunawardene YINS |
| List of Research Outputs |
| Gunawardene Y.I.N.S., Bendena W.G., Tobe S.S. and Chan S.M., Comparative immunohistochemistry and cellular distribution of farnesoic acid Omethyltransferase in the shrimp and the crayfish, Peptides. 2003, 24: 1591-1597. |
| Researcher : Hon CC |
| List of Research Outputs |
| Chow Y.C.K., Hon C.C., Hui K.H., Wong T.Y., Yip C.W., Zeng F. and Leung F.C.C., Molecular Advances in Severe Acute Respiratory Syndrome-associated Coronavirus (SARS-CoV), Genomics, Proteomics and Bioinformatics. 2003, 1: 247-262. |
| Guan Y., Peiris J.S.M., Zheng B., Poon L.L.M., Chan K.H., Zeng F., Chan W.M., Chan M.N., Chen J., Chow Y.C.K., Hon C.C., Hui K.H., Li J., Li Y.Y., Wang Y., Leung C.S.W., Yuen K.Y. and Leung F.C.C., Molecular epidemiology of the novel coronavirus that causes severe acute respiratory syndrome, The Lancet. 2004, 363: 99-104. |
| Hon C.C., Chow Y.C.K., Zeng F. and Leung F.C.C., Genetic Authentication of Ginseng and Other Traditional Chinese Medicine, Acta Pharmacologica Sinica. 2003, 24: 841-846. |
| Zeng F., Chow Y.C.K., Hon C.C., Law K.M., Yip C.W., Chan K.H., Peiris J.S.M. and Leung F.C.C., Characterization of humoral responses in mice immunized with plasmid DNAs encoding SARS-CoV spike gene fragments, Biochemical and Biophysical Research Communications. 2004, 315: 1134-1139. |
| Zeng F., Hon C.C., Chow Y.C.K. and Leung F.C.C., Standardization of TCM by Genetic and Functional Authentication, Medicine in the 21st Century Tri-Conference & Bio-Forum, July 24th to 27th 2004, Shanghai, China. 2004. |
| Zeng F., Chan W.M., Chan M.N., Chen J., Chow Y.C.K., Hon C.C., Hui K.H., Li J., Li Y.Y., Wang Y., Wang Y., Guan Y., Zheng B., Poon L.L.M., Chan K.H., Yuen K.Y., Peiris J.S.M. and Leung F.C.C., The Complete Genome Sequence of Severe Acute Respiratory Syndrome Coronavirus Strain HKU-39849 (HK-39), Experimental Biology Medicine. 2003, 228: 866-873. |
| Researcher : Hoo LCR |
| List of Research Outputs |
| Cheng C.K., Hoo L.C.R., Chow B.K.C. and Leung P.C.K., Functional Cooperation between Multiple Regulatory Elements in the Untranslated Exon 1 Stimulates the Basal Transcription of the Human GnRH-II Gene, Molecular Endocrinology. 2003, 17: 1175-1191. |
| Chow B.K.C., Moon T.W., Hoo L.C.R., Yeung C.M., Muller M., Christos P.J. and Mojsov S., Identification and Characterization of a Glucagon Receptor from the Goldfish Carassius auratus: Implications for the Evolution of the Ligand Specificity of Glucagon Receptors in Vertebrates , Endocrinology. 2004, 145: 3273-3288. |
| Researcher : Hu K |
| List of Research Outputs |
| Hu K. and Leung P.C., Shrimp cathepsin L encoded by an intronless gene has predominant expression in hepatopancreas, and occurs in the nucleus of oocyte, Comparative Biochemistry and Physiology Part B. 2004, 137: 21-33. |
| Researcher : Hui KH |
| List of Research Outputs |
| Chow Y.C.K., Hon C.C., Hui K.H., Wong T.Y., Yip C.W., Zeng F. and Leung F.C.C., Molecular Advances in Severe Acute Respiratory Syndrome-associated Coronavirus (SARS-CoV), Genomics, Proteomics and Bioinformatics. 2003, 1: 247-262. |
| Guan Y., Peiris J.S.M., Zheng B., Poon L.L.M., Chan K.H., Zeng F., Chan W.M., Chan M.N., Chen J., Chow Y.C.K., Hon C.C., Hui K.H., Li J., Li Y.Y., Wang Y., Leung C.S.W., Yuen K.Y. and Leung F.C.C., Molecular epidemiology of the novel coronavirus that causes severe acute respiratory syndrome, The Lancet. 2004, 363: 99-104. |
| Hui K.H., Zeng F., Chan M.N., Yuen K.Y., Peiris J.S.M. and Leung F.C.C., RT-PCR Diagnosis of Coronavirus Associated with Severe Acute Respiratory Syndrome (SARS), Journal Clinical Microbiology. 2004, 42: 1994-1999. |
| Zeng F., Chan W.M., Chan M.N., Chen J., Chow Y.C.K., Hon C.C., Hui K.H., Li J., Li Y.Y., Wang Y., Wang Y., Guan Y., Zheng B., Poon L.L.M., Chan K.H., Yuen K.Y., Peiris J.S.M. and Leung F.C.C., The Complete Genome Sequence of Severe Acute Respiratory Syndrome Coronavirus Strain HKU-39849 (HK-39), Experimental Biology Medicine. 2003, 228: 866-873. |
| Researcher : Hui MYA |
| List of Research Outputs |
| Hui M.Y.A., Wang C.Y. and Leung F.C.C., Molecular Characterization of the Chicken Prolactin Receptor Gene, In: Trends in Comparative Endocrinology, Editors: T Oishi, K Tsutsui, S Tanaka, S Kikuyama, Proceedings of the Fifth Congress of Asia & Oceania Society for Comparative Endocrinology in Conjunction with the Annual Meeting of JSCE, March 26-30, 2004, Nara, Japan. 2004, 33-35. |
| Researcher : Ip CY |
| List of Research Outputs |
| Ip C.Y., Lau S.L.J., Au W.L. and Leung F.C.C., Characterization of the 5'-flanking transcriptional regulatory region of the chicken growth hormone gene , Biotechnology, Agronomy Society and Environment. 2004, 8 (Sp. Issue): 36. |
| Researcher : King DE |
| List of Research Outputs |
| Mei J., Zhang Y.Q., King D.E., Sangild P. and Xu R.J., Distribution and Developmental Changes of Transforming Growth Factor-beta Receptors in the Small Intestine of the Pig, Journal Of Animal And Veterinary Advances. 2004, 3: 89-106. |
| Mei J., Zhang Y.Q., King D.E. and Xu R.J., Effects of Milk Diets on Transforming Growth Factor-beta Receptor Expression in the Small Intestine in Newborn Piglets , Proceedings of 46th Annual Meeting of Canadian Federation of Biological Society, Ottawa, Canada on June 13, 2003 (Abstract F056). 2003, p102. |
| Researcher : Ko KW |
| List of Research Outputs |
| Wong A.O.L., Zhou H., Ko K.W. and Ho W.K.K., A Novel Feedback Mechanism Regulating Growth Hormone Synthesis and Secretion in Chinese Grass Carp (Ctenopharyngodon idellus), Journal of the Fisheries Society of Taiwan. 2004, 31: 141-153. |
| Zhou H., Ko K.W., Ho W.K.K., Stojilkovic S.S. and Wong A.O.L., Novel Aspects of Growth Hormone (GH) Autoregulation: GH-Induced GH Gene Expression in Grass Carp Pituitary Cells through Autocrine/Paracrine Mechanisms, Endocrinology. 2004, 145: 4615-4628. |
| Researcher : Ko RCC |
| Project Title: | Mechanisms of inflammatory evasion by trichinellid nematodes which infect mammals |
| Investigator(s): | Prof. Ko R.C.C., Dr. Mak C.H. |
| Department: | Zoology |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 11/2001 |
| Completion Date: | 10/2003 |
| Abstract: |
| To determine the general effects of the excretory/secretory (ES) products of the infective-stage larvae of two species of parasitic nematodes on cellular response in muscles; to study the differential Ig isotype switching and T helper cell activation induced by the larvae and their ES products; to determine the effects of ES products on T-lymphocyte proliferation; to test the adjuvanticity of the ES products. |
| Project Title: | Prevalence of two protozoan pathogens, Girardia and Cryptosporidium, in the water supplies of Hong Kong |
| Investigator(s): | Prof. Ko R.C.C., Dr. Mak C.H., Prof. Singh M., Prof. Wu R.S.S. |
| Department: | Zoology |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | 10/2002 |
| Abstract: |
| The study attempts to:- 1) determine the general prevalence of two organisms, Giardia intestinalis and Cryptosporidium parvum, in Hong Kong water supplies; 2) determine the major source of contamination; 3) determine, if any, the seasonal incidence of these two organisms in various water supplies. |
| Project Title: | Modulation of cell-mediated immune and inflammatory responses by Trichinella pseudospiralis during the acute muscle phase of infection- the roles of adhesion molecules and chemokines |
| Investigator(s): | Prof. Ko R.C.C., Dr. Mak C.H. |
| Department: | Zoology |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 11/2002 |
| Abstract: |
| To further characterise the cell-mediated immune (systemic) response during the early phase of worm infection; to determine the roles of adhesion molecules and chemokines in suppression of inflammatory/immune response after the newborn larvae have invaded the striated muscles; to test the hypothesis that this species of nematode produce effector molecules to evade host's response. |
| Project Title: | Studies on some heat-induced genes of an intracellular parasitic nematode, Trichinella pseudospiralis II. Cloning and characterization of a homologue of translationally controlled tumour proteins (TCTP) |
| Investigator(s): | Prof. Ko R.C.C., Dr. Mak C.H. |
| Department: | Zoology |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 11/2003 |
| Abstract: |
| To complete our preliminary experiments by cloning and sequencing the entire transcript of the translationally controlled tumour protein (TCTP) of Trichinella; to elucidate the gene structure; to express the recombinant protein; to assay the biological functions of the protein and to assess its role in the infectious process. |
| List of Research Outputs |
| Wong C.S., Mak C. and Ko R.C.C., Cloning and characterization of the mitochondrial heat-shock protein 60 gene of Trichinella spiralis, Parasitology Research. 2004, 93: 461-467. |
| Researcher : Kwok YY |
| List of Research Outputs |
| Kwok Y.Y., Chu Y.S.J., Anouar Y., Tse L.Y. and Chow B.K.C., Cloning and characterizing PAC1 receptor-Hop1 splice variant in goldfish (Carrasius auratus), 11th Meeting of the European Neuroendocrine Association, Sorrento, Italy. 2004. |
| Researcher : Lau SLJ |
| List of Research Outputs |
| Ip C.Y., Lau S.L.J., Au W.L. and Leung F.C.C., Characterization of the 5'-flanking transcriptional regulatory region of the chicken growth hormone gene , Biotechnology, Agronomy Society and Environment. 2004, 8 (Sp. Issue): 36. |
| Researcher : Law KM |
| List of Research Outputs |
| Zeng F., Chow Y.C.K., Hon C.C., Law K.M., Yip C.W., Chan K.H., Peiris J.S.M. and Leung F.C.C., Characterization of humoral responses in mice immunized with plasmid DNAs encoding SARS-CoV spike gene fragments, Biochemical and Biophysical Research Communications. 2004, 315: 1134-1139. |
| Researcher : Lee MY |
| List of Research Outputs |
| Chow B.K.C., Cheung K.H., Tsang E.M.W., Leung M.C.T., Lee M.Y. and Wong P.Y.D., Secretin Controls Anion Secretion in the Rat Epididymis in an Autocrine/Paracrine Fashion, Biology of Reproduction. 2004, 70: 1594-1599. |
| Chu Y.S.J., Lee M.Y., Yung W.H. and Chow B.K.C., Localization and the release mechanism of secretin in hypothalamo-pituitary system of the Wistar Rat Rattus novegicus, 11th Meeting of the European Neuroendocrine Association, Sorrento, Italy. 2004. |
| Lee M.Y., Yung W.H., Ng S.M., Chen L. and Chow B.K.C., Electrophysiological effects and release characteristics in the rat cerebellum, 6th IBRO World congress of Neuroscience, Prague, Czech Republic. 2003. |
| Lee T.O., Lee M.Y., Tan-Un K.C. and Chow B.K.C., Expression Regulation of the Secretin gene in Human Neuroblastoma cells throughout Retinoic acid induced Neuronal differentiation, 6th IBRO World congress of Neuroscience, Prague, Czech Republic. 2003. |
| Researcher : Lee TO |
| List of Research Outputs |
| Lee T.O., Lee M.Y., Tan-Un K.C. and Chow B.K.C., Expression Regulation of the Secretin gene in Human Neuroblastoma cells throughout Retinoic acid induced Neuronal differentiation, 6th IBRO World congress of Neuroscience, Prague, Czech Republic. 2003. |
| Lee T.O., Tan-Un K.C., Pang R.T.K., Lam D.T.W. and Chow B.K.C., Regulation of the Human Secretin Gene is Controlled by the Combined Effects of CpG Methylation, Sp1/Sp3 Ratio, and the E-Box Element , Molecular Endocrinology. 2004, 18: 1740-1755. |
| Pang T.K.R., Lee T.O., Ng S.M., Yung W.H. and Chow B.K.C., CpG Methylation and Transcription Factors Sp1 and Sp3 Regulate the Expression of the Human Secretin Receptor Gene, Molecular Endocrinology. 2004, 18: 471-483. |
| Researcher : Lee WWM |
| Project Title: | Analysis of the promoter sequence of rat and mouse testin |
| Investigator(s): | Prof. Lee W.W.M. |
| Department: | Zoology |
| Source(s) of Funding: | The Population Council, U.S.A. |
| Start Date: | 07/1999 |
| Abstract: |
| To analysis promoter sequence of rat and mouse testin. |
| Project Title: | Gas6 expression and tyrosine kinase phosphorlation in testicular cell lines |
| Investigator(s): | Prof. Lee W.W.M. |
| Department: | Zoology |
| Source(s) of Funding: | The Population Council, U.S.A. |
| Start Date: | 08/1999 |
| Abstract: |
| To study Gas6 expression and tyrosine kinase phosphorlation in testicular cell lines. |
| Project Title: | Disassembly of cell junctions in the testis |
| Investigator(s): | Prof. Lee W.W.M., Dr. Cheng C.Y. |
| Department: | Zoology |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | 09/2001 |
| Abstract: |
| To identify target genes that are involved in junction disassembly between testicular cells by an in vitro cadmium chloride disassembly model system. Peptides of 20-25 amino acids will be synthesized based on the extracellular domains of Cx-33 (a testis-specific GJ protein) and occludin (a TJ protein found in the testis). 2.a. These peptides and their corresponding antibodies will be used to perturb cell junction assembly in vitro. 2.b. The active peptide will be injested intratesticularly to assess its effects in vivo. To use antisense oligodeoxynucleotides (ODNs) specific to Cx33, a testi-specific GJ protein largely expressed by germ cells, to perturb the GJs between testicular cells. It is anticipated such a disruption will impair germ cell movement when communications between Sertoli and germ cells are disrupted. 3.a. Antisense ODNs will be screened in vitro by using Sertoli cell cultures and Sertoli-germ cell cocultures to select ODNs that can arrest the timely expression of Cx33. 3.b. Selected ODNs will be injected intratesticularly to assess their effects in the seminiferous epithelium in vivo. |
| Project Title: | Induction of germ cell loss by a synthetic occludin peptide and its mechanism of action: an in vivo model to study cell junction formation in the testis |
| Investigator(s): | Prof. Lee W.W.M., Dr. Cheng C.Y., Dr. Lui W.Y. |
| Department: | Zoology |
| Source(s) of Funding: | RGC Projects (Block Grant Funded) |
| Start Date: | 07/2003 |
| Abstract: |
| To examine the mechanism by which occludin peptide induces germ cell loss in the seminiferous epithelium; to investigate the integrity of the BTB in the peptide-injected testis and correlate with the kinetics of testicular changes; to examine whether the recovery of the BTB following the occludin peptide-induced damage to the Sertoli cell-TJ barrier is regulated, at least in part, by TGF-b. |
| Project Title: | Differential expression and transcriptional regulation of the Tyro 3 receptor tyrosine kinases in the testis |
| Investigator(s): | Prof. Lee W.W.M. |
| Department: | Zoology |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 11/2003 |
| Abstract: |
| To characterize the suppressing region of -26/+126, and to compare the difference in the transcriptional mechanism of the other two members of Tyro 3 family. |
| List of Research Outputs |
| Lee C.Y.L., Lee C.K.F., Xu J., He Q., Chiu J., Lee W.W.M., Luk J.M.C. and Yeung W.S.B., Identification of human oviducutal cell derived embryotrophic factor-3 (ETF-3), Symposium on Reproductive Health, Macau, Hong Kong and Inland China, Macau, May 29-31, 2004 . 2004. |
| Lee C.Y.L., Lee C.K.F., Xu J., He Q., Chiu J., Lee W.W.M., Luk J.M.C. and Yeung W.S.B., The embryotrophic activity of oviductal cell-derived complement C3b and iC3b, a novel function of complement protein in reproduction, The Journal of Biological Chemistry. 2004, 279(13): 12763-12768. |
| Lui W.Y., Cheng C.Y. and Lee W.W.M., Regulation of Sertoli-germ cell adherens junctions by interplay of CDC42 and its effector protein, IQGAP1, Annual Scientific Meeting of the Hong Kong Society for the Study of Endocrinology, Metabolism and Reproduction. 2003. |
| Siu K.Y., Cheng C.Y. and Lee W.W.M., Regulation of ectoplasmic specialization dynamics in the testis by phosphinostitide 3-kinase via the b1-integrin/pFAK/P13K/PKB Signaling pathway, 4th Asian & Oceanic Congress of Andrology, Penang, Malaysia. 2004. |
| Wong C.S. and Lee W.W.M., Identification of the cis-acting elements Sp1, Lyf-1, Myo D and Hand 1 as down-regulators of Mer transcription in Sertoli cells, Annual Scientific Meeting of the Hong Kong Society for the Study of Endocrinology, Metabolism and Reproduction. 2003. |
| Yao Y., Xu J., Lee W.W.M., Yeung W.S.B. and Lee C.K.F., Identification of mRNAs that are up-regulated after fertilization in the murine zygote by suppression subtractive hybridization, Biochemical and Biophysical Research Communications. 2003, 304: 60-66. |
| Researcher : Leung FCC |
| Project Title: | Genetic marker for the mouse wobbler mutation |
| Investigator(s): | Dr. Leung F.C.C. |
| Department: | Zoology |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 07/1998 |
| Abstract: |
| To develop genetic marker using repetitive sequences as probes for the early detection of mouse wobbler mutation. |
| Project Title: | Isolation and characterization of the porcine reproductive and respiratory syndrome virus |
| Investigator(s): | Dr. Leung F.C.C. |
| Department: | Zoology |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 07/1999 |
| Abstract: |
| To develop molecular genetic assay for typing the Porcine Reproductive and Respiratory Syndrome Virus (PRRS). |
| Project Title: | Cloning of the viral genes from the newly identified SARS coronavirus |
| Investigator(s): | Dr. Leung F.C.C. |
| Department: | Zoology |
| Source(s) of Funding: | SARS Research Fund |
| Start Date: | 07/2003 |
| Abstract: |
| To clone all the viral gene into vector and these cloned genes will be then be used as reagents by us and other as the first step for investigation. |
| Project Title: | Development of a rapid high throughput RT-PCR assay to detect SARS-CoV |
| Investigator(s): | Dr. Leung F.C.C. |
| Department: | Zoology |
| Source(s) of Funding: | SARS Research Fund |
| Start Date: | 07/2003 |
| Abstract: |
| To develop a 96-wells RT-PCR platform assay for the detection of the coronavirus. |
| Project Title: | Rapid accurate diagnostic assay for the SARS coronavirus |
| Investigator(s): | Dr. Leung F.C.C., Prof. Peiris J.S.M. |
| Department: | Zoology |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | 09/2003 |
| Abstract: |
| To develop an S gene based ELISA assay for serological assessment of the population after the initial outbreak of SARS and to further develop the current RT-PCR assay for diagnosis the SARS Coronavirus developed in our laboratory into a rapid accurate high through-put assay that can accommodate up to thousands of samples per day. |
| Project Title: | Molecular cloning of the chicken growth hormone receptor and the molecular characterization of the 5'-flanking region |
| Investigator(s): | Dr. Leung F.C.C. |
| Department: | Zoology |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | 10/2003 |
| Abstract: |
| To determine the molecular structure and nucleotide sequence of the chicken GHR gene and the multiple 5' UTR exon 1. |
| Project Title: | Molecular cloning of the chicken growth hormone receptor and the molecular characterization of the 5'-flanking region |
| Investigator(s): | Dr. Leung F.C.C. |
| Department: | Zoology |
| Source(s) of Funding: | RGC Projects (Block Grant Funded) |
| Start Date: | 10/2003 |
| Abstract: |
| To determine the molecular structure and nucleotide sequence of the chicken GHR gene and the multiple 5' UTR exon 1. |
| Project Title: | Isolation and characterization of a PCV2 virus causing postweaning multisystemic wasting syndrome in pigs |
| Investigator(s): | Dr. Leung F.C.C. |
| Department: | Zoology |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 11/2003 |
| Abstract: |
| To isolate and characterize the PCV2 virus that causes the Postweaning multisystemic wasting syndrome (PMWS) in pigs. |
| List of Research Outputs |
| Chan P.K.S., Tam J.S., Sung J.J.Y., Zeng F., Chow Y.C.K. and Leung F.C.C., Estimated Timing of the Last Common Ancestor of the SARS Coronavirus, New England Journal of Medicine. 2003, 349: 2469-2470. |
| Chow Y.C.K., Hon C.C., Hui K.H., Wong T.Y., Yip C.W., Zeng F. and Leung F.C.C., Molecular Advances in Severe Acute Respiratory Syndrome-associated Coronavirus (SARS-CoV), Genomics, Proteomics and Bioinformatics. 2003, 1: 247-262. |
| Guan Y., Peiris J.S.M., Zheng B., Poon L.L.M., Chan K.H., Zeng F., Chan W.M., Chan M.N., Chen J., Chow Y.C.K., Hon C.C., Hui K.H., Li J., Li Y.Y., Wang Y., Leung C.S.W., Yuen K.Y. and Leung F.C.C., Molecular epidemiology of the novel coronavirus that causes severe acute respiratory syndrome, The Lancet. 2004, 363: 99-104. |
| Hon C.C., Chow Y.C.K., Zeng F. and Leung F.C.C., Genetic Authentication of Ginseng and Other Traditional Chinese Medicine, Acta Pharmacologica Sinica. 2003, 24: 841-846. |
| Hui K.H., Zeng F., Chan M.N., Yuen K.Y., Peiris J.S.M. and Leung F.C.C., RT-PCR Diagnosis of Coronavirus Associated with Severe Acute Respiratory Syndrome (SARS), Journal Clinical Microbiology. 2004, 42: 1994-1999. |
| Hui M.Y.A., Wang C.Y. and Leung F.C.C., Molecular Characterization of the Chicken Prolactin Receptor Gene, In: Trends in Comparative Endocrinology, Editors: T Oishi, K Tsutsui, S Tanaka, S Kikuyama, Proceedings of the Fifth Congress of Asia & Oceania Society for Comparative Endocrinology in Conjunction with the Annual Meeting of JSCE, March 26-30, 2004, Nara, Japan. 2004, 33-35. |
| Ip C.Y., Lau S.L.J., Au W.L. and Leung F.C.C., Characterization of the 5'-flanking transcriptional regulatory region of the chicken growth hormone gene , Biotechnology, Agronomy Society and Environment. 2004, 8 (Sp. Issue): 36. |
| Leung F.C.C., Hong Kong SARS sequence, Science. 2003, 301: 309-310. |
| Li J. and Leung F.C.C., Characterization of a Novel Highly Repetitive DNA Family: Hingf I Repeat From the Chicken Genome, Plant and Animal Genome XI, San Diego, USA . 2003. |
| Ng W.C., Sadovy Y.J. and Leung F.C.C., Mating system of the rockfish, Sebastiscus marmoratus as revealed by DNA fingerprinting, Ichthyological Research . 2003, 50(4): 339-348. |
| Wang Y. and Leung F.C.C., An evaluation of new criteria for CpG islands in the human genome as gene markers, Bioinformatics. 2004, 20: 1170-1177. |
| Wong Y.L., Wu H. and Leung F.C.C., Characterization of Guangzhou Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Field Isolates, Journal of Animal and Veterinary Advances. 2003, 2: 452-456. |
| Wu H., Chen J. and Leung F.C.C., Chicken Infectious Diseases Virus Recombinant DNA Constructs and its Efficacy in Special Pathogen Free Chickens, Journal of Animal and Veterinary Advances. 2003, 2: 448-451. |
| Zeng F., Chow Y.C.K., Hon C.C., Law K.M., Yip C.W., Chan K.H., Peiris J.S.M. and Leung F.C.C., Characterization of humoral responses in mice immunized with plasmid DNAs encoding SARS-CoV spike gene fragments, Biochemical and Biophysical Research Communications. 2004, 315: 1134-1139. |
| Zeng F., Hon C.C., Chow Y.C.K. and Leung F.C.C., Standardization of TCM by Genetic and Functional Authentication, Medicine in the 21st Century Tri-Conference & Bio-Forum, July 24th to 27th 2004, Shanghai, China. 2004. |
| Zeng F., Chan W.M., Chan M.N., Chen J., Chow Y.C.K., Hon C.C., Hui K.H., Li J., Li Y.Y., Wang Y., Wang Y., Guan Y., Zheng B., Poon L.L.M., Chan K.H., Yuen K.Y., Peiris J.S.M. and Leung F.C.C., The Complete Genome Sequence of Severe Acute Respiratory Syndrome Coronavirus Strain HKU-39849 (HK-39), Experimental Biology Medicine. 2003, 228: 866-873. |
| Zhou G. and Leung F.C.C., Molecular Characterization of Chicken SOCS2 Gene, Poulty Science. 2004, 83 (Supp. I):: 263. |
| Researcher : Leung PC |
| Project Title: | Characterization of a new form of the fyn oncogene |
| Investigator(s): | Dr. Leung P.C. |
| Department: | Zoology |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 07/1998 |
| Abstract: |
| To characterize this new variant form of the fyn oncogene, so as to assess the significance of this new fyn gene in the cell. |
| List of Research Outputs |
| Hu K. and Leung P.C., Shrimp cathepsin L encoded by an intronless gene has predominant expression in hepatopancreas, and occurs in the nucleus of oocyte, Comparative Biochemistry and Physiology Part B. 2004, 137: 21-33. |
| Wang Y., Leung P.C. and Gu J., Complete nucleotide sequence of a cryptic plasmid isolated from Vibrio cholerae MP-1 and identification of the open reading frames, Croucher Advanced Study Institute - Surface Adhesion and Biotechnological Applications. October 27-30, 2003. The University of Hong Kong, SAR, China. 2003, p. 57. |
| Wang Y., Leung P.C. and Gu J., Complete nucleotide sequence of a cryptic plasmid isolated from Vibrio cholerae MP-1, Symposium on Marine Biology and Biotechnology. April 20-24, 2004. Hong Kong. 2004, p. 72. |
| Wang Y.L., Leung P.C., Qian P.Y. and Gu J., Effects of UV, H2O2 and Fe3+ on the Growth of Four Environmental Isolates of Aeromonas and Vibrio Species from a Mangrove Environment, Microbes Environments. 2004, 19: 163-171. |
| Wong A.S.T., Leung P.C. and Auersperg N., Influence of constitutive E-cadherin expression in HGF-mediated invasive growth in ovarian surface epithelial cells, Proceedings Society for the Study of Endocrinology, Metabolism and Reproduction . 2003, 20-29. |
| Researcher : Li ETS |
| Project Title: | Body mass index, adiposity, serum leptin and insulin sensitivity in Chinese and Caucasians: a comparative study |
| Investigator(s): | Dr. Li E.T.S., Prof. Anderson G.H., Dr. He M., Prof. Lam K.S.L., Dr. Tan K.C.B. |
| Department: | Zoology |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | 12/2000 |
| Abstract: |
| To compare healthy Chinese and Caucasions to study the association between, first, body mass index (BMI) and body fat and insulin sensitivity, and second BMI and glucose disposal rate. Results of this study will provide information required for assessing the validity of the international criteria for obesity and may lead to establishing specific overweight and obesity definitions for Chinese population. |
| Project Title: | An evaluation on the antioxidant effects of Lycium barbarum L. and its supplementation on cataract formation in rats |
| Investigator(s): | Dr. Li E.T.S. |
| Department: | Zoology |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 11/2003 |
| Abstract: |
| To systematically examine the antioxidant properties of Lycium barbarum L. and evaluate the effect of its supplementation on cataract development in rats. |
| Project Title: | Dietary bitter melon reduces adiposity and enhances insulin sensitivity: a role for peroxisome proliferator-activated receptors? |
| Investigator(s): | Dr. Li E.T.S. |
| Department: | Zoology |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | 12/2003 |
| Abstract: |
| Determine the effect of bitter melon supplementation on adiposity, glucose tolerance and endocrine profile of insulin resistant rats; determine the involvement of peroxisome proliferators-activated receptors and adipocyte-derived peptides; determine the involvement of sympathetic activity and uncoupling proteins from brown and white adipocytes, and skeletal muscle. |
| Project Title: | Dietary bitter melon reduces adiposity and enhances insulin sensitivity: a role for peroxisome proliferator-activated receptors? |
| Investigator(s): | Dr. Li E.T.S. |
| Department: | Zoology |
| Source(s) of Funding: | RGC Projects (Block Grant Funded) |
| Start Date: | 12/2003 |
| Abstract: |
| Determine the effect of bitter melon supplementation on adiposity, glucose tolerance and endocrine profile of insulin resistant rats; determine the involvement of peroxisome proliferators-activated receptors and adipocyte-derived peptides; determine the involvement of sympathetic activity and uncoupling proteins from brown and white adipocytes, and skeletal muscle. |
| Researcher : Li J |
| List of Research Outputs |
| Guan Y., Peiris J.S.M., Zheng B., Poon L.L.M., Chan K.H., Zeng F., Chan W.M., Chan M.N., Chen J., Chow Y.C.K., Hon C.C., Hui K.H., Li J., Li Y.Y., Wang Y., Leung C.S.W., Yuen K.Y. and Leung F.C.C., Molecular epidemiology of the novel coronavirus that causes severe acute respiratory syndrome, The Lancet. 2004, 363: 99-104. |
| Li J. and Leung F.C.C., Characterization of a Novel Highly Repetitive DNA Family: Hingf I Repeat From the Chicken Genome, Plant and Animal Genome XI, San Diego, USA . 2003. |
| Zeng F., Chan W.M., Chan M.N., Chen J., Chow Y.C.K., Hon C.C., Hui K.H., Li J., Li Y.Y., Wang Y., Wang Y., Guan Y., Zheng B., Poon L.L.M., Chan K.H., Yuen K.Y., Peiris J.S.M. and Leung F.C.C., The Complete Genome Sequence of Severe Acute Respiratory Syndrome Coronavirus Strain HKU-39849 (HK-39), Experimental Biology Medicine. 2003, 228: 866-873. |
| Researcher : Li YY |
| List of Research Outputs |
| Guan Y., Peiris J.S.M., Zheng B., Poon L.L.M., Chan K.H., Zeng F., Chan W.M., Chan M.N., Chen J., Chow Y.C.K., Hon C.C., Hui K.H., Li J., Li Y.Y., Wang Y., Leung C.S.W., Yuen K.Y. and Leung F.C.C., Molecular epidemiology of the novel coronavirus that causes severe acute respiratory syndrome, The Lancet. 2004, 363: 99-104. |
| Zeng F., Chan W.M., Chan M.N., Chen J., Chow Y.C.K., Hon C.C., Hui K.H., Li J., Li Y.Y., Wang Y., Wang Y., Guan Y., Zheng B., Poon L.L.M., Chan K.H., Yuen K.Y., Peiris J.S.M. and Leung F.C.C., The Complete Genome Sequence of Severe Acute Respiratory Syndrome Coronavirus Strain HKU-39849 (HK-39), Experimental Biology Medicine. 2003, 228: 866-873. |
| Researcher : Lim BL |
| Project Title: | Molecular characterization of a new foot-and-mouth disease virus strain isolated in Hong Kong |
| Investigator(s): | Dr. Lim B.L. |
| Department: | Zoology |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 07/1998 |
| Abstract: |
| To sequence the full length genome (approximate 8 kb) of the local FMDV strain. |
| Project Title: | Acute infectious bursal disease in poultry: epidemiology of the disease, basis of virulence and improvement of vaccination |
| Investigator(s): | Dr. Lim B.L., Dr. Eterradossi N., Prof. Muller H., Dr. Van den Berg T. |
| Department: | Zoology |
| Source(s) of Funding: | European Commission International Cooperation |
| Start Date: | 01/1999 |
| Abstract: |
| To study: 1) development and harmonisation of the diagnostic tools; 2) molecular epidemiology of vvIBDV; 3) constitution of an IBDV genomic cDNA bank and generation of relevant full length cDNA's that could be used in the reverse genetics system to generate genetically engineered recombinant infectious viral clones; 4) harmonisation of nomenclature of IBDV strains based on molecular criteria; 5) pathogenesis of the disease: search for cell receptors and virulence markers - molecular basis of attenuation - cell-mediated immune response; 6) improvement of the vaccination protocols: reverse genetics system - DNA vaccination. |
| Project Title: | Generation of VP5-deletion mutants from recombinant IBDV viruses by reverse genetics |
| Investigator(s): | Dr. Lim B.L. |
| Department: | Zoology |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 07/1999 |
| Abstract: |
| To generate more recombinant mutants by site-directed mutagenesis and reverse genetics technolgoy, which can be used to evaluate the effects of certain amino acids on the pathogenicity of the virus. |
| Project Title: | Identification and molecular cloning of infectious bursal disease virus (IBDV) receptors on chicken cells |
| Investigator(s): | Dr. Lim B.L. |
| Department: | Zoology |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | 02/2000 |
| Abstract: |
| To clone and identify the receptors of infectious bursal disease virus (IBDV) by both molecular and biochemical approaches. |
| Project Title: | Identification and molecular cloning of infectious bursal disease virus (IBDV) receptors on chicken cells |
| Investigator(s): | Dr. Lim B.L. |
| Department: | Zoology |
| Source(s) of Funding: | RGC Projects (Block Grant Funded) |
| Start Date: | 02/2000 |
| Abstract: |
| To clone and identify the receptors of infectious bursal disease virus (IBDV) by both molecular and biochemical approaches. |
| Project Title: | Development of manufacturing processes for industrial enzymes |
| Investigator(s): | Dr. Lim B.L., Mr. Chan J., Ms Lau J. |
| Department: | Zoology |
| Source(s) of Funding: | Innovation and Technology Fund, Innovation and Technology Commission of Hong Kong Government |
| Start Date: | 11/2001 |
| Completion Date: | 01/2004 |
| Abstract: |
| To develop manufacturing processes for three lines of products, including 1) protease for detergent application, 2) lipase for detergent application and 3) cellulases for textile application. |
| Project Title: | Regulatory mechanism of the bacteriophage phi-105 |
| Investigator(s): | Dr. Lim B.L., Dr. Leung T.Y.C. |
| Department: | Zoology |
| Source(s) of Funding: | RGC Projects (Block Grant Funded) |
| Start Date: | 07/2003 |
| Abstract: |
| To paint a clearer picture of the regulatory mechanism of this Bacillus bacteriophage. |
| Project Title: | Characterization of phytase-like proteins from Shewanella oneidensis and nostoc punctiforme |
| Investigator(s): | Dr. Lim B.L. |
| Department: | Zoology |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 11/2003 |
| Abstract: |
| To study the biochemical propeties of two puttive proteins, they are Shewanella oneidensis and Nostoc punctiforme, including substrate specificity, pH / temperature profiles and thermostability and compare them with the Bacillus phytases; to explore their physiological functions beside phytate-hydrolyzing activity, since both putative proteins were substantially larger than Bacillus phytases. |
| List of Research Outputs |
| Chan Y.M. and Lim B.L., Interaction of a Putative Transcriptional Regulatory Protein and the Thermo-inducible cts-52 Mutant Repressor in the Bacillus subtilis Phage f105 Genome , Journal of Molecular Biology. 2003, 333: 21-31. |
| Ho K.M. and Lim B.L., Co-expression of a prophage system and a plasmid system in Bacillus subtilis, Protein Expression and Purification. 2003, 32: 293-301. |
| Lim B.L. and Yip W.K., Recombinant Bacillus Phytases and uses thereof, The University of Hong Kong (patent filed). 2003. |
| Yip W.K., Wang L.J., Cheng C.W., Wu W.L., Lung S.C. and Lim B.L., The Introduction of a phytase gene from Bacillus subtilis improved the growth performance of transgenic tobacco, Biochemical and Biophysical Research Communications. 2003, 310: 1148-1154. |
| Researcher : Lui WY |
| List of Research Outputs |
| Lui W.Y., Cheng C.Y. and Lee W.W.M., Regulation of Sertoli-germ cell adherens junctions by interplay of CDC42 and its effector protein, IQGAP1, Annual Scientific Meeting of the Hong Kong Society for the Study of Endocrinology, Metabolism and Reproduction. 2003. |
| Researcher : Lung SC |
| List of Research Outputs |
| Yip W.K., Wang L.J., Cheng C.W., Wu W.L., Lung S.C. and Lim B.L., The Introduction of a phytase gene from Bacillus subtilis improved the growth performance of transgenic tobacco, Biochemical and Biophysical Research Communications. 2003, 310: 1148-1154. |
| Researcher : Mak C |
| List of Research Outputs |
| Wong C.S., Mak C. and Ko R.C.C., Cloning and characterization of the mitochondrial heat-shock protein 60 gene of Trichinella spiralis, Parasitology Research. 2004, 93: 461-467. |
| Researcher : Mei J |
| List of Research Outputs |
| Cheung H.K., Mei J., Wang T. and Xu R.J., Detection and Characterization of Soluble Betaglycan in Porcine Milk, Journal of Animal and Veterinary Advances. 2004, 3: 278-284. |
| Cheung H.K., Mei J. and Xu R.J., Quantification of soluble betaglycan in porcine milk, Asia Pacific Journal of Clinical Nutrition . 2003, 12 (Suppl.): S61. |
| Mei J., Zhang Y.Q., King D.E., Sangild P. and Xu R.J., Distribution and Developmental Changes of Transforming Growth Factor-beta Receptors in the Small Intestine of the Pig, Journal Of Animal And Veterinary Advances. 2004, 3: 89-106. |
| Mei J., Zhang Y.Q., King D.E. and Xu R.J., Effects of Milk Diets on Transforming Growth Factor-beta Receptor Expression in the Small Intestine in Newborn Piglets , Proceedings of 46th Annual Meeting of Canadian Federation of Biological Society, Ottawa, Canada on June 13, 2003 (Abstract F056). 2003, p102. |
| Researcher : Pang RTK |
| List of Research Outputs |
| Lee T.O., Tan-Un K.C., Pang R.T.K., Lam D.T.W. and Chow B.K.C., Regulation of the Human Secretin Gene is Controlled by the Combined Effects of CpG Methylation, Sp1/Sp3 Ratio, and the E-Box Element , Molecular Endocrinology. 2004, 18: 1740-1755. |
| Pang T.K.R., Lee T.O., Ng S.M., Yung W.H. and Chow B.K.C., CpG Methylation and Transcription Factors Sp1 and Sp3 Regulate the Expression of the Human Secretin Receptor Gene, Molecular Endocrinology. 2004, 18: 471-483. |
| Researcher : Siu KY (Siu Kwan Yee) |
| List of Research Outputs |
| Siu K.Y., Cheng C.Y. and Lee W.W.M., Regulation of ectoplasmic specialization dynamics in the testis by phosphinostitide 3-kinase via the b1-integrin/pFAK/P13K/PKB Signaling pathway, 4th Asian & Oceanic Congress of Andrology, Penang, Malaysia. 2004. |
| Researcher : Siu KY (Siu Kwan Yin) |
| List of Research Outputs |
| Siu K.Y., Sham M.H., Ng S.M. and Chow B.K.C., The Expression of Secretin in the Mouse Embryonic Development, 6th IBRO World congress of Neuroscience, Prague, Czech Republic. 2003. |
| Researcher : Sun M |
| Project Title: | Population genetics, phylogenetic relationships, and conservation of mangroves |
| Investigator(s): | Dr. Sun M., Dr. Duke N.C. |
| Department: | Zoology |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | 09/2000 |
| Abstract: |
| To provide baseline information pertinent to genetic conservation and management of mangroves. The project focuses on the genetic diversity of important mangrove species and factors affecting this diversity, adn to establish the identity of Rhizophora taxa for conservation management. |
| List of Research Outputs |
| Bao J., Sun M., Zhu L. and Corke H., Analysis of quantitative trait loci for some starch properties of rice (Oryza sativa L.): thermal properties, gel texture and swelling volume, Journal of Cereal Science. 2004, 39: 379-385. |
| Bao J., Sun M. and Corke H., Genetic diversity of starch physicochemical properties of waxy rice (Oryza sativa L.), Journal of the Science of Food and Agriculture. 2004, 84: 1299-1306. |
| Cai Y., Luo Q., Sun M. and Corke H., Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer, Life Sciences. 2004, 74: 2157-2184. |
| Researcher : Tan-Un KC |
| Project Title: | Genetic variations associated with hereditary persistence of fetal hemoglobin (HPFH) in Chinese |
| Investigator(s): | Dr. Tan-Un K.C., Dr. Philipsen J.N.J.S. |
| Department: | Zoology |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 10/2002 |
| Completion Date: | 09/2003 |
| Abstract: |
| To construct genomic libraries of this family with HPFH. The clones containing the b-globin cluster will be subjected to functional analysis to enable us to screen and identify regulatory elements that could be implicated in the switch from fetal g to b-globin. |
| List of Research Outputs |
| Chan M.M.W., Lam W.K., Mak J.C.W., Ho S.P., Chan R.H.W., Tsang K.W.T., Ip M.S.M., Ho J.C.M., Wong M.P. and Tan-Un K.C., Polymorphisms of CYP and GST genes, passive smoke and lung cancer risk in Hong Kong Chinese, 9th Medical Research Conference, Medical Science Group, The University of Hong Kong. 2004, Abstract Book: RC-11. |
| Lee T.O., Lee M.Y., Tan-Un K.C. and Chow B.K.C., Expression Regulation of the Secretin gene in Human Neuroblastoma cells throughout Retinoic acid induced Neuronal differentiation, 6th IBRO World congress of Neuroscience, Prague, Czech Republic. 2003. |
| Lee T.O., Tan-Un K.C., Pang R.T.K., Lam D.T.W. and Chow B.K.C., Regulation of the Human Secretin Gene is Controlled by the Combined Effects of CpG Methylation, Sp1/Sp3 Ratio, and the E-Box Element , Molecular Endocrinology. 2004, 18: 1740-1755. |
| Tan-Un K.C., Chang K.R. and Chan M.M.W., Use of a food frequency questionnaire on Chinese diet to assess antioxidant status in individuals with asthma, Nutrition Research. 2004, 24: 509-519. |
| Researcher : Tse LY |
| List of Research Outputs |
| Kwok Y.Y., Chu Y.S.J., Anouar Y., Tse L.Y. and Chow B.K.C., Cloning and characterizing PAC1 receptor-Hop1 splice variant in goldfish (Carrasius auratus), 11th Meeting of the European Neuroendocrine Association, Sorrento, Italy. 2004. |
| Researcher : Wan JMF |
| Project Title: | To determine the mechanisms of apoptosis of polysaccharide peptide (PSP) in human leukemic cell lines and human normal lymphocytes |
| Investigator(s): | Dr. Wan J.M.F. |
| Department: | Zoology |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | 09/2003 |
| Abstract: |
| To determine the apoptotic pathways of PSP-induced apoptosis in various human leukemic cell eines; to identify the survival pathways in the human normal lymphocytes in response to PSP-induced apoptosis. |
| Project Title: | To determine the mechanisms of apoptosis of polysaccharide peptide (PSP) in human leukemic cell lines and human normal lymphocytes |
| Investigator(s): | Dr. Wan J.M.F. |
| Department: | Zoology |
| Source(s) of Funding: | RGC Projects (Block Grant Funded) |
| Start Date: | 09/2003 |
| Abstract: |
| To determine the apoptotic pathways of PSP-induced apoptosis in various human leukemic cell eines; to identify the survival pathways in the human normal lymphocytes in response to PSP-induced apoptosis. |
| Researcher : Wang Y (Wang Yong) |
| List of Research Outputs |
| Wang Y. and Leung F.C.C., An evaluation of new criteria for CpG islands in the human genome as gene markers, Bioinformatics. 2004, 20: 1170-1177. |
| Researcher : Wang Y (Wang Ying) |
| List of Research Outputs |
| Guan Y., Peiris J.S.M., Zheng B., Poon L.L.M., Chan K.H., Zeng F., Chan W.M., Chan M.N., Chen J., Chow Y.C.K., Hon C.C., Hui K.H., Li J., Li Y.Y., Wang Y., Leung C.S.W., Yuen K.Y. and Leung F.C.C., Molecular epidemiology of the novel coronavirus that causes severe acute respiratory syndrome, The Lancet. 2004, 363: 99-104. |
| Researcher : Wong AOL |
| Project Title: | Pituitary adenylate cyclase activating polypeptide as a novel growth hormone releasing factor in Chinese grass carp, Ctenopharyngodon idellus |
| Investigator(s): | Dr. Wong A.O.L. |
| Department: | Zoology |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | 01/1999 |
| Abstract: |
| To establish the functional role of PACAP as a novel regulator of GH secretion and body growth in the grass carp. |
| Project Title: | Novel aspects of adrenergic regulation of growth hormone release in fish |
| Investigator(s): | Dr. Wong A.O.L. |
| Department: | Zoology |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | 01/2002 |
| Abstract: |
| To elucidate the neuroendocrine control and signal transduction mechanisms regulating growth hormone(GH) secretion in fish; to characterize the a2 adrenoreceptor subtype(s) expressed in goldfish somatotrophs; to elucidate the signaling pathways responsible for adrenergic regulation of GH release in goldfish pituitary cells. |
| Project Title: | Regulation of growth hormone synthesis in fish: mechanisms of action of the novel hypophysiotropic factor pituitary adenylate cyclase-activating polypeptide |
| Investigator(s): | Dr. Wong A.O.L. |
| Department: | Zoology |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | 12/2002 |
| Abstract: |
| The project aims at understanding the mechanisms and evolution of neuroendocrine control of body growth in lower vertebrates. The research on GH synthesis and secretion of vertebrate endocrine will also provide new insights on the role of hormone biosynthesis in "stimulus-secretion" coupling of vertebrate endocrine systems. |
| Project Title: | Novel aspects of growth hormone autoregulation in grass carp pituitary cells:- intrapituitary "ultra-short" feedback on growth hormone gene expression in fish? |
| Investigator(s): | Dr. Wong A.O.L. |
| Department: | Zoology |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | 12/2003 |
| Abstract: |
| To establish the structural identity of grass carp GH receptor; to provide a full-length receptor cDNA for subsequent functional expression studies; to confirm the expression of GH receptors in immuno-identified grass carp somatotrophs; to characterize ligand-binding properties of grass carp GH receptors expressed in CHO cells; to show the functional coupling of grass carp GH receptors with Ca2+i and Spi 2.1 gene activation; to examine the role of GH on GH synthesis and GH mRNA expression in grass carp pituitary cells; to examine the role of endogenous GH on GH mRNA expression induced by GH-releasing factors; to examine the effects of inhibiting the JAK/MARK cascade in GH-induced GH mRNA expression; to examine the effects of inhibiting the JAK/IRS/P13K cascade in GH-induced GH mRNA expression; to demonstrate GH modulation of GH transcript stability by altering the half-life (T1/2) of GHmRNA; to show that GH is essential to maintain basal expression of GH primary transcripts in the nucleus; to test if GH can alter the 5' promoter activity of grass carp GH gene using a reporter gene assay. |
| Project Title: | Novel aspects of growth hormone autoregulation in grass carp pituitary cells:- intrapituitary "ultra-short" feedback on growth hormone gene expression in fish? |
| Investigator(s): | Dr. Wong A.O.L. |
| Department: | Zoology |
| Source(s) of Funding: | RGC Projects (Block Grant Funded) |
| Start Date: | 12/2003 |
| Abstract: |
| To establish the structural identity of grass carp GH receptor; to provide a full-length receptor cDNA for subsequent functional expression studies; to confirm the expression of GH receptors in immuno-identified grass carp somatotrophs; to characterize ligand-binding properties of grass carp GH receptors expressed in CHO cells; to show the functional coupling of grass carp GH receptors with Ca2+i and Spi 2.1 gene activation; to examine the role of GH on GH synthesis and GH mRNA expression in grass carp pituitary cells; to examine the role of endogenous GH on GH mRNA expression induced by GH-releasing factors; to examine the effects of inhibiting the JAK/MARK cascade in GH-induced GH mRNA expression; to examine the effects of inhibiting the JAK/IRS/P13K cascade in GH-induced GH mRNA expression; to demonstrate GH modulation of GH transcript stability by altering the half-life (T1/2) of GHmRNA; to show that GH is essential to maintain basal expression of GH primary transcripts in the nucleus; to test if GH can alter the 5' promoter activity of grass carp GH gene using a reporter gene assay. |
| Project Title: | Paracrine regulation of growth hormone gene expression by gonadotropin secretion in carp pituitary cells |
| Investigator(s): | Dr. Wong A.O.L. |
| Department: | Zoology |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 02/2004 |
| Abstract: |
| To demonstrate the expression of GTH-II/LH receptors in immuno-identified carp somatotrophs; to examine the role of GTH-II in regulating the expression of GH primary transcripts in carp pituitary cells; to map the coarse location of "responsive sequence(s)" in the 5' promoter of grass carp GH gene mediating GTH-II induction of GH gene transcription. |
| List of Research Outputs |
| Wang Y.J., Wong A.O.L. and Ge W., Cloning, Regulation of Messenger Ribonucleic Acid Expression, and Function of a New Isoform of Pituitary Adenylate Cyclase-Activating Polypeptide in the Zebrafish Ovary, Endocrinology. 2003, 144: 4799-4810. |
| Wong A.O.L., Zhou H., Ko K.W. and Ho W.K.K., A Novel Feedback Mechanism Regulating Growth Hormone Synthesis and Secretion in Chinese Grass Carp (Ctenopharyngodon idellus), Journal of the Fisheries Society of Taiwan. 2004, 31: 141-153. |
| Zhou H., Ko K.W., Ho W.K.K., Stojilkovic S.S. and Wong A.O.L., Novel Aspects of Growth Hormone (GH) Autoregulation: GH-Induced GH Gene Expression in Grass Carp Pituitary Cells through Autocrine/Paracrine Mechanisms, Endocrinology. 2004, 145: 4615-4628. |
| Researcher : Wong AST |
| Project Title: | Mechanism of the growth suppressor activity of E-cadherin in human epithelial tumours |
| Investigator(s): | Dr. Wong A.S.T. |
| Department: | Zoology |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 01/2003 |
| Completion Date: | 12/2003 |
| Abstract: |
| To understand the mechanism underlying the growth suppressor activity of E-cadherin in human epithelial tumours. |
| Project Title: | HGF-Met and Wnt-b-catenin signaling in human ovarian biology and cancer development |
| Investigator(s): | Dr. Wong A.S.T. |
| Department: | Zoology |
| Source(s) of Funding: | RGC Projects (Block Grant Funded) |
| Start Date: | 07/2003 |
| Abstract: |
| To test whether constitutively active HGF/Met signaling plays a causative role in the development of ovarian cancer; to investigate the role of HGF in OSE, and uncover the signal transduction mechanism underlying its function; to elucidate the role of b-catenin in ovarian cell physiology, and determine how it is regulated by reproductive endocrine factors. |
| Project Title: | The role of hepatocyte growth factor (HGF) in ovarian carcinoma cell migration/invasion |
| Investigator(s): | Dr. Wong A.S.T. |
| Department: | Zoology |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 11/2003 |
| Abstract: |
| To study the downstream signaling pathways mediated by HGF for the invasive growth in human ovarian tumours. |
| List of Research Outputs |
| Maines-Bandiera S.L., Huntsman D., Lestou V.S., Kuo W.L., Leung P.C.K., Horsman R.D., Wong A.S.T., Woo M.M.M., Choi K.K.C., Roskelley C.D. and Auersperg N., Epithelio-mesenchymal transition in a neoplastic ovarian epithelial hybrid cell line, International Society of Differentiation. 2004, 72: 150-161. |
| Wong A.S.T. and Gumbiner B.M., 43rd Annual Meeting of the American Association for Cell Biology, San Francisco, CA, Molecular and Cellular Biology. 2003, 14 (Suppl.): 452 (Abstract No. 2533). |
| Wong A.S.T. and Gumbiner B.M., Adhesion-independent mechanism for suppression of tumor cell invasion by E-cadherin, The Journal of Cell Biology. 2003, 161: 1191-1203. |
| Wong A.S.T., Leung P.C. and Auersperg N., Influence of constitutive E-cadherin expression in HGF-mediated invasive growth in ovarian surface epithelial cells, Proceedings Society for the Study of Endocrinology, Metabolism and Reproduction . 2003, 20-29. |
| Wong A.S.T. and Auersperg N., Ovarian surface epithelium: family history and early events in ovarian cancer, Reproductive Biology and Endocrinology. 2003, 1:70. |
| Wong A.S.T., Roskelley C.D., Pelech S., Miller D., Leung P.C.K. and Auersperg N., Progressive changes in Met-dependent signaling in a human ovarian surface epithelial model of malignant transformation, Experimental Cell Research. 2004, 299: 248-256. |
| Researcher : Wong CS (Wong Chui Shan) |
| List of Research Outputs |
| Wong C.S. and Lee W.W.M., Identification of the cis-acting elements Sp1, Lyf-1, Myo D and Hand 1 as down-regulators of Mer transcription in Sertoli cells, Annual Scientific Meeting of the Hong Kong Society for the Study of Endocrinology, Metabolism and Reproduction. 2003. |
| Researcher : Wong CS (Wong Chi Sun) |
| List of Research Outputs |
| Wong C.S., Mak C. and Ko R.C.C., Cloning and characterization of the mitochondrial heat-shock protein 60 gene of Trichinella spiralis, Parasitology Research. 2004, 93: 461-467. |
| Researcher : Wong TY |
| List of Research Outputs |
| Chow Y.C.K., Hon C.C., Hui K.H., Wong T.Y., Yip C.W., Zeng F. and Leung F.C.C., Molecular Advances in Severe Acute Respiratory Syndrome-associated Coronavirus (SARS-CoV), Genomics, Proteomics and Bioinformatics. 2003, 1: 247-262. |
| Researcher : Wong YL |
| List of Research Outputs |
| Wong Y.L., Wu H. and Leung F.C.C., Characterization of Guangzhou Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Field Isolates, Journal of Animal and Veterinary Advances. 2003, 2: 452-456. |
| Researcher : Wu H |
| List of Research Outputs |
| Wong Y.L., Wu H. and Leung F.C.C., Characterization of Guangzhou Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Field Isolates, Journal of Animal and Veterinary Advances. 2003, 2: 452-456. |
| Wu H., Chen J. and Leung F.C.C., Chicken Infectious Diseases Virus Recombinant DNA Constructs and its Efficacy in Special Pathogen Free Chickens, Journal of Animal and Veterinary Advances. 2003, 2: 448-451. |
| Researcher : Xu RJ |
| Project Title: | A study on the physiological role of transforming growth factor b in postnatal adaptation of the gastrointestinal tract in neonatal pigs |
| Investigator(s): | Dr. Xu R.J. |
| Department: | Zoology |
| Source(s) of Funding: | Block Grant Earmarked for Research |
| Start Date: | 11/2003 |
| Abstract: |
| To investigate the possible physiological role of TGF-b in regulation of postnatal adaptation of the gastrointestinal tract in neonatal animals. |
| Project Title: | Postnatal adaptation of the gastrointestinal tract in neonatal pigs: a possible role of transforming growth factor-b |
| Investigator(s): | Dr. Xu R.J. |
| Department: | Zoology |
| Source(s) of Funding: | Hong Kong Research Grants Council Competitive Earmarked Research Grants |
| Start Date: | 12/2003 |
| Abstract: |
| To examine concentration changes of TGF-b in milk during the lactation; to study chemical properties of TGF-b in milk; to examine the stability of milk-borne TGF-b in the GI lumen; to study the development changes of endogenous production of TGF-b in the GI tract; to study the effects of milk on intestinal mutation in newborn piglets; to study the endogenous production of TGF-D and its receptors in the gastrointestinal tract in early-weaned piglets. |
| Project Title: | Postnatal adaptation of the gastrointestinal tract in neonatal pigs: a possible role of transforming growth factor-b |
| Investigator(s): | Dr. Xu R.J. |
| Department: | Zoology |
| Source(s) of Funding: | RGC Projects (Block Grant Funded) |
| Start Date: | 12/2003 |
| Abstract: |
| To examine concentration changes of TGF-b in milk during the lactation; to study chemical properties of TGF-b in milk; to examine the stability of milk-borne TGF-b in the GI lumen; to study the development changes of endogenous production of TGF-b in the GI tract; to study the effects of milk on intestinal mutation in newborn piglets; to study the endogenous production of TGF-D and its receptors in the gastrointestinal tract in early-weaned piglets. |
| List of Research Outputs |
| Cheung H.K., Mei J., Wang T. and Xu R.J., Detection and Characterization of Soluble Betaglycan in Porcine Milk, Journal of Animal and Veterinary Advances. 2004, 3: 278-284. |
| Cheung H.K., Mei J. and Xu R.J., Quantification of soluble betaglycan in porcine milk, Asia Pacific Journal of Clinical Nutrition . 2003, 12 (Suppl.): S61. |
| Mei J., Zhang Y.Q., King D.E., Sangild P. and Xu R.J., Distribution and Developmental Changes of Transforming Growth Factor-beta Receptors in the Small Intestine of the Pig, Journal Of Animal And Veterinary Advances. 2004, 3: 89-106. |
| Mei J., Zhang Y.Q., King D.E. and Xu R.J., Effects of Milk Diets on Transforming Growth Factor-beta Receptor Expression in the Small Intestine in Newborn Piglets , Proceedings of 46th Annual Meeting of Canadian Federation of Biological Society, Ottawa, Canada on June 13, 2003 (Abstract F056). 2003, p102. |
| Zhang Y.Q., Hu J., Liu X.P. and Xu R.J., Expression and Localization of SMAD4 Protein in Rat Testis during the Postnatal Development , Chinese Medical Sciences Journal. 2003, 18: 155-161. |
| Researcher : Yeung CM |
| List of Research Outputs |
| Chow B.K.C., Moon T.W., Hoo L.C.R., Yeung C.M., Muller M., Christos P.J. and Mojsov S., Identification and Characterization of a Glucagon Receptor from the Goldfish Carassius auratus: Implications for the Evolution of the Ligand Specificity of Glucagon Receptors in Vertebrates , Endocrinology. 2004, 145: 3273-3288. |
| Researcher : Yeung HY |
| List of Research Outputs |
| Yeung H.Y., Chan D.K.O., Mak N.K., Wagner G.F. and Wong C.K.C., Identification of Signal Transduction Pathways that Modulate Dibutyryl Cyclic Adenosine Monophosphate Activation of Stanniocalcin Gene Expression in Neuroblastoma Cells, Endocrinology. 2003, 144: 4446-4452. |
| Researcher : Yip CW |
| List of Research Outputs |
| Chow Y.C.K., Hon C.C., Hui K.H., Wong T.Y., Yip C.W., Zeng F. and Leung F.C.C., Molecular Advances in Severe Acute Respiratory Syndrome-associated Coronavirus (SARS-CoV), Genomics, Proteomics and Bioinformatics. 2003, 1: 247-262. |
| Zeng F., Chow Y.C.K., Hon C.C., Law K.M., Yip C.W., Chan K.H., Peiris J.S.M. and Leung F.C.C., Characterization of humoral responses in mice immunized with plasmid DNAs encoding SARS-CoV spike gene fragments, Biochemical and Biophysical Research Communications. 2004, 315: 1134-1139. |
| Researcher : Zeng F |
| List of Research Outputs |
| Chan P.K.S., Tam J.S., Sung J.J.Y., Zeng F., Chow Y.C.K. and Leung F.C.C., Estimated Timing of the Last Common Ancestor of the SARS Coronavirus, New England Journal of Medicine. 2003, 349: 2469-2470. |
| Chow Y.C.K., Hon C.C., Hui K.H., Wong T.Y., Yip C.W., Zeng F. and Leung F.C.C., Molecular Advances in Severe Acute Respiratory Syndrome-associated Coronavirus (SARS-CoV), Genomics, Proteomics and Bioinformatics. 2003, 1: 247-262. |
| Guan Y., Peiris J.S.M., Zheng B., Poon L.L.M., Chan K.H., Zeng F., Chan W.M., Chan M.N., Chen J., Chow Y.C.K., Hon C.C., Hui K.H., Li J., Li Y.Y., Wang Y., Leung C.S.W., Yuen K.Y. and Leung F.C.C., Molecular epidemiology of the novel coronavirus that causes severe acute respiratory syndrome, The Lancet. 2004, 363: 99-104. |
| Hon C.C., Chow Y.C.K., Zeng F. and Leung F.C.C., Genetic Authentication of Ginseng and Other Traditional Chinese Medicine, Acta Pharmacologica Sinica. 2003, 24: 841-846. |
| Hui K.H., Zeng F., Chan M.N., Yuen K.Y., Peiris J.S.M. and Leung F.C.C., RT-PCR Diagnosis of Coronavirus Associated with Severe Acute Respiratory Syndrome (SARS), Journal Clinical Microbiology. 2004, 42: 1994-1999. |
| Zeng F., Chow Y.C.K., Hon C.C., Law K.M., Yip C.W., Chan K.H., Peiris J.S.M. and Leung F.C.C., Characterization of humoral responses in mice immunized with plasmid DNAs encoding SARS-CoV spike gene fragments, Biochemical and Biophysical Research Communications. 2004, 315: 1134-1139. |
| Zeng F., Hon C.C., Chow Y.C.K. and Leung F.C.C., Standardization of TCM by Genetic and Functional Authentication, Medicine in the 21st Century Tri-Conference & Bio-Forum, July 24th to 27th 2004, Shanghai, China. 2004. |
| Zeng F., Chan W.M., Chan M.N., Chen J., Chow Y.C.K., Hon C.C., Hui K.H., Li J., Li Y.Y., Wang Y., Wang Y., Guan Y., Zheng B., Poon L.L.M., Chan K.H., Yuen K.Y., Peiris J.S.M. and Leung F.C.C., The Complete Genome Sequence of Severe Acute Respiratory Syndrome Coronavirus Strain HKU-39849 (HK-39), Experimental Biology Medicine. 2003, 228: 866-873. |
| Researcher : Zhang YQ |
| List of Research Outputs |
| Mei J., Zhang Y.Q., King D.E., Sangild P. and Xu R.J., Distribution and Developmental Changes of Transforming Growth Factor-beta Receptors in the Small Intestine of the Pig, Journal Of Animal And Veterinary Advances. 2004, 3: 89-106. |
| Mei J., Zhang Y.Q., King D.E. and Xu R.J., Effects of Milk Diets on Transforming Growth Factor-beta Receptor Expression in the Small Intestine in Newborn Piglets , Proceedings of 46th Annual Meeting of Canadian Federation of Biological Society, Ottawa, Canada on June 13, 2003 (Abstract F056). 2003, p102. |
| Zhang Y.Q., Hu J., Liu X.P. and Xu R.J., Expression and Localization of SMAD4 Protein in Rat Testis during the Postnatal Development , Chinese Medical Sciences Journal. 2003, 18: 155-161. |
| Researcher : Zhou G |
| List of Research Outputs |
| Zhou G. and Leung F.C.C., Molecular Characterization of Chicken SOCS2 Gene, Poulty Science. 2004, 83 (Supp. I):: 263. |
| Researcher : Zhou H |
| List of Research Outputs |
| Wong A.O.L., Zhou H., Ko K.W. and Ho W.K.K., A Novel Feedback Mechanism Regulating Growth Hormone Synthesis and Secretion in Chinese Grass Carp (Ctenopharyngodon idellus), Journal of the Fisheries Society of Taiwan. 2004, 31: 141-153. |
| Zhou H., Ko K.W., Ho W.K.K., Stojilkovic S.S. and Wong A.O.L., Novel Aspects of Growth Hormone (GH) Autoregulation: GH-Induced GH Gene Expression in Grass Carp Pituitary Cells through Autocrine/Paracrine Mechanisms, Endocrinology. 2004, 145: 4615-4628. |