DEPT OF ORTHOPAEDICS AND TRAUMATOLOGY
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Researcher
: Abbah SA |
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List of Research Outputs |
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Abbah S.A., Lu W.W., Chan D., Cheung K.M.C., Liu W., Zhao F., Li Z., Leong J.C.Y. and Luk K.D.K., In vitro evaluation of alginate encapsulated adipose-tissue stromal cells for use as injectable bone graft substitute., Biochem Biophys Res Commun. 2006, 347(1): 185-91. |
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Li Z., Lam R.W.M., Yang C., Xu B., Ni G., Abbah S.A., Cheung K.M.C., Luk K.D.K. and Lu W.W., Chemical composition, crystal size and lattice structural changes after incorporation of strontium into biomimetic apatite, Biomaterials. 2007, 28(7): 1452-60. |
|
Researcher
: Abbah SA |
|
List of Research Outputs |
|
Abbah S.A., Lu W.W., Chan D., Cheung K.M.C., Liu W., Zhao F., Li Z., Leong J.C.Y. and Luk K.D.K., In vitro evaluation of alginate encapsulated adipose-tissue stromal cells for use as injectable bone graft substitute., Biochem Biophys Res Commun. 2006, 347(1): 185-91. |
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Li Z., Lam R.W.M., Yang C., Xu B., Ni G., Abbah S.A., Cheung K.M.C., Luk K.D.K. and Lu W.W., Chemical composition, crystal size and lattice structural changes after incorporation of strontium into biomimetic apatite, Biomaterials. 2007, 28(7): 1452-60. |
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Researcher
: Aladin KDM |
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List of Research Outputs |
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Aladin K.D.M., Lu W.W., Cheung K.M.C., Ngan A.H.W., Chan D. and Luk K.D.K., " Nano Biomechanics Of
Type Ii Collagens In Human Intervertebral Discs", Best Paper Award;
Conference on Biomedical Engineering, BME 2006. |
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Researcher
: Aladin Kaderbatcha DM |
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List of Research Outputs |
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Aladin
Kaderbatcha D.M., Lu W.W., Chan D., Yee A.F.Y., Jim J.J.T., Luk K.D.K. and Cheung K.M.C., EXPRESSION OF THE TRP2
ALLELE OF COL |
|
Aladin
Kaderbatcha D.M., Lu W.W., Cheung K.M.C., Ngan A.H.W., Chan D. and Luk K.D.K., Nano Structure and
Biomechanics of Human Intervertebral Disc Collagens, International Society
for the Study of the Lumbar Spine. 34th annual Meeting, June 10-14, |
|
List of Research Outputs |
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Cheah K.S.E., Au Y.K., Wynn S.L., Geng G.Y.H. and Cheung K.M.C., Insight into the molecular pathogenesis of campomelic dysplasia revealed by a conditional Sox9 mutant mouse model. , Cold Spring Harbor Meeting on Mouse Molecular Genetics, Cold Spring Harbor, 30 Aug - 3 Sept 2006 New York, USA. 2006. |
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Researcher
: Chan CCY |
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List of Research Outputs |
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Choi
M.Y., Chan C.C.Y., Chan D., Luk K.D.K., Cheah K.S.E. and Tanner J.A., Molecular Mechanism of
Disease for Spondyloepiphyseal Dysplasia Tarda-Effect of Mutations on sedlin
structure and Function., 11th Research Postgraduate Symposium, 7 Dec.
2006. The |
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Researcher
: Chan CF |
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List of Research Outputs |
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Chan
C.F. and Leung
K.L., Locking compression plate fixation of distal humeral fractures, The
26th Hong Kong Orthopaedic Association Annual Congress, |
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Lau T.W., Leung K.L., Chan C.F. and Chow S.P., Minimally invasive plate fixation of proximal humeral fractures, The 26th Hong Kong Orthopaedic Association Annual Congress, Hong Kong, 11-12 November 2006, . 2006. |
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Researcher
: Chan CW |
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List of Research Outputs |
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Chan
C.W., Gantenbein B., Chan D., Lu W., Cheung K.M.C., Lezuo P. and Ito K., Fate
of Mesenchymal Stem Cells Injected Into Intervertebral Discs, International
Society for the Study of the Lumbar Spine. 34th Annual Meeting. |
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Researcher
: Chan YL |
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List of Research Outputs |
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Chan
Y.L., Yeung
K.W.K., Ngan A.H.W., Cheung K.M.C., Lu W.W., Luk K.D.K., Liu X.M. and |
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Chan
Y.L., Yeung
K.W.K., Lu W.W., Ngan A.H.W., Luk K.D.K., Chan D., Wu S.L., Liu X.M., |
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Liu X., Wu S., Chan Y.L., |
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Liu X.M., Wu S.L., |
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Wu S.L., Chung C.Y., Liu X.M., |
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Yeung
K.W.K., Chan Y.L., Lam K.O., Liu X.Y., Chung C.Y., |
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Yeung
K.W.K., Wu S.L., Liu X.M., Chung C.Y., |
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Yeung
K.W.K., Lam K.O., Chan Y.L., Wu S.L., Liu X.Y., Chung
C.Y., |
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Yeung
K.W.K., Chan Y.L., Lam K.O., Liu X.Y., Chung C.Y., |
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Researcher
: Cheung KMC |
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Project Title: |
Setting Up of a Stem Cell Research Programme for Musculoskeletal Tissue Repair |
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Investigator(s): |
Cheung KMC, Chan D |
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Department: |
Orthopaedics and Traumatology |
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Source(s) of Funding: |
The |
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Start Date: |
07/2003 |
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Abstract: |
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To explore a novel method of intervertebral disc repair by implanting autologous MSCs into the degenerated intervertebral disc using a rabbit model. |
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Project Title: |
The impact of
the COL |
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Investigator(s): |
Cheung KMC, Cheah KSE, Lu WW, Chan D, Luk KDK |
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Department: |
Orthopaedics and Traumatology |
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Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
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Start Date: |
01/2005 |
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Abstract: |
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To collect and store degenerated and non-degenerated human intervertebral discs and DNA; to examine these retrieved specimens for expression of [alpha]2(IX)Trp, collagen IX cross-linking abnormalites, cellular and extracellular matrix abnormalties and alternations in mechanical properties. |
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Project Title: |
Intervertebral disc regeneration by use of mesenchymal stem cells |
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Investigator(s): |
Cheung KMC, Chan D, Wu EX, Luk KDK |
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Department: |
Orthopaedics and Traumatology |
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Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
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Start Date: |
01/2006 |
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Abstract: |
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(1) What is the fate of the transplanted MSCs within the IVD; (2) at what stage of degeneration is cell therapy most effective; (3) could allogeneic MSCs be used for transplantation; (4) what are the long term effects of transplanted MSCs. |
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Project Title: |
New compounds for intervertebral disc regeneration by Chemical Genetics |
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Investigator(s): |
Cheung KMC, Leung YL, Kao RYT, Chan D |
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Department: |
Orthopaedics and Traumatology |
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Source(s) of Funding: |
Seed Funding Programme for Basic Research |
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Start Date: |
06/2006 |
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Abstract: |
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Low back pain is a significant cause of
morbidity and disability. It is one of the most frequent reasons for clinic
visits, loss of work hours and billions of dollars of expenditure in
treatment and wage compensation. Although low back pain is complex in
aetiology, chronic low back pain is commonly associated with degeneration of
the intervertebral disc (IVD). Patients with severe IVD degeneration and pain
often require surgery with its associated morbidity.Adult IVD cells have
similar biological phenotype to chondrocytes1, using this knowledge various
biological therapies for IVD regeneration have emerged. This includes
injection of biomolecules such as OP-1/BMP-2/GDF-5 2-4 and adenoviral
delivery of Sox9 gene 5 into degenerated discs. Chemical genetics is an
emerging technique that uses small chemical compounds to alter the functions
of proteins to which they bind. The principle is similar to how genes are
manipulated in knock-out or transgenic animal models to understand the
function of a particular gene; the downstream effects of alterations of these
proteins can be evaluated to understand the function of the protein and its
pathway, hence the term "Chemical Genetics". It is thus used to
identify which proteins regulate different biological processes, to
understand in molecular detail how proteins perform their biological
functions, and to identify small compounds that may be of medical value.
Through strategic design of screening assays, this technology has been
successfully employed to identify potential pharmaceuticals for cancers 6, 7,
diabetes 8, cardiovascular diseases 9, and neurodegeneration 10, 11. The
Department of Microbiology at The University of Hong Kong has the only high
throughput chemical genetics screening platform in Asia, and they have
successfully used this technology to identify compounds that have
anti-SARS-coV and anti-angiogenesis activity 12, 13.Using the principle of "Forward
Genetics", we aim to perform a primary screen of a library of over
50,000 small compounds using goat chondrocytes, and to select those that are
able to maintain or increase proteoglycan levels. Recent evidence that a
number of molecular pathways are involved in IVD degeneration, and that an
orally administered drug, Esculetin can reverse IVD degeneration in rabbits
14, would support that other small compounds and pathways that may act
similarly or even more specifically can be identified. Reference list:1.
Hunter, C. J., Matyas, J. R. & Duncan, N. A. Tissue Eng 9, 667-77
(2003).2. An, H. S. et al. Spine 30, 25-31; discussion 31-2 (2005).3. Li, J.,
Yoon, S. T. & Hutton, W. C. J Spinal Disord Tech 17, 423-8 (2004).4. Li,
X., Leo, B. M., Beck, G., Balian, G. & Anderson, G. D. Spine 29, 2229-34
(2004).5. Paul, R. et al. Spine 28, 755-63 (2003).6. Lam, K. S. Anticancer
Drug Des 12, 145-67 (1997).7. Remiszewski, S. W. Curr Med Chem 10, 2393-402
(2003).8. Shi, G. Q. et al. J Med Chem 48, 4457-68 (2005).9. Bush, E. et al.
Proc Natl Acad Sci U S A 101, 2870-5 (2004).10. Apostol, B. L. et al. Proc
Natl Acad Sci U S A 100, 5950-5 (2003).11. |
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Project Title: |
Uncovering new compounds and mechanisms for treatment of intervertebral disc degeneration by chemical genetics |
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Investigator(s): |
Cheung KMC, Leung YL, Kao RYT, Chan D |
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Department: |
Orthopaedics and Traumatology |
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Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
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Start Date: |
01/2007 |
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Abstract: |
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(1) High throughput identification of compounds that can increase proteoglycan content in an in vitro culture of goat chondrocytes; (2) to investigate their possible mechanisms of action by gene expression profiling; (3) In vitro vertification that compounds with desirable molecular actions is capable of acting on human IVD cells and chondrocytes. |
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Project Title: |
MicroRNA expression and function in intervertebral disc cells |
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Investigator(s): |
Cheung KMC, Zhou G, Chan D |
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Department: |
Orthopaedics and Traumatology |
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Source(s) of Funding: |
Seed Funding Programme for Basic Research |
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Start Date: |
03/2007 |
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Abstract: |
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Degeneration of the intervertebral disc (IVD) is attributed to senescence and/or apoptosis of cells and downregulation of synthetic activities. Little is known about how these processes are regulated in IVD cells. MicroRNA (miRNA) genes have been recently recognized to play important roles in various physiological and pathological processes by their powerful regulation of gene expression, and is also known to be expressed in cartilage. Whether they are involved in the regulation of IVD cells is not known, but this information may provide new insight into the regulation of IVD degeneration and therefore ways to halt or regenerate it. This proposal aims to develop this new technology and assess the presence and regulatory roles of miRNA genes in IVD cells in comparison with chondrocytic progenitors cells by: 1) To assess and compare the expression profile of miRNA genes in nucleus pulposus (NP), annulus fibrosus (AF) cells and cartilage of young, adult and aged rats. 2) To assess and compare the expression profile of miRNA genes in NP and AF cells of human subjects. |
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List of Research Outputs |
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Abbah S.A., Lu W.W., Chan D., Cheung K.M.C., Liu W., Zhao F., Li Z., Leong J.C.Y. and Luk K.D.K., In vitro evaluation of alginate encapsulated adipose-tissue stromal cells for use as injectable bone graft substitute., Biochem Biophys Res Commun. 2006, 347(1): 185-91. |
|
Aladin
K.D.M., Lu W.W., Cheung K.M.C., Ngan A.H.W., Chan D. and Luk K.D.K., " Nano Biomechanics Of
Type Ii Collagens In Human Intervertebral Discs", Best Paper Award;
Conference on Biomedical Engineering, BME 2006. |
|
Aladin
Kaderbatcha D.M., Lu W.W., Chan D., Yee A.F.Y., Jim J.J.T., Luk K.D.K. and Cheung K.M.C., EXPRESSION OF THE
TRP2 ALLELE OF COL |
|
Aladin
Kaderbatcha D.M., Lu W.W., Cheung K.M.C., Ngan A.H.W., Chan D. and Luk K.D.K., Nano Structure and
Biomechanics of Human Intervertebral Disc Collagens, International Society
for the Study of the Lumbar Spine. 34th annual Meeting, June 10-14, |
|
Bullmann V., Cheung K.M.C., Halm H.H.F., Senkoylu A., Luk K.D.K. and Liljenqvist U.R., Comparative sagittal plane correction after anterior single rod versus dual rod instrumentation in idiopathic thoracolumbar and lumbar scoliosis, EuroSpine 2006, Istanbul, Turkey, October 25-28, 2006. |
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Chan B.P., Cheung K.M.C., Chan G.C.F., Chan D. and Hui T.Y., Bioengineered intervertebral disc and Methods for Their Preparation., US Regular Patent Application No. 11/742,040 (filed on 30 April 2007). 2007. |
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Chan B.P., Hui T.Y., Chan C.M., So K.F., Lu W., Cheung K.M.C., Salomatina E. and Yaroslavsky A., Photochemical cross-linking for collagen-based scaffolds: a study on optical properties, mechanical properties, stability, and hematocompatibility, Tissue Engineering. 2007, 13(1): 73-85. |
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Chan
C.W., Gantenbein B., Chan D., Lu W., Cheung K.M.C., Lezuo P. and Ito K.,
Fate of Mesenchymal Stem Cells Injected Into Intervertebral Discs, International
Society for the Study of the Lumbar Spine. 34th Annual Meeting. |
|
Chan D., Song Y., Sham P.C. and Cheung K.M.C., Genetics of disc degeneration, Eur Spine J. 2006, 15 Suppl 15: 317-25. |
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Chan
Y.L., Yeung K.W.K., Ngan A.H.W., Cheung K.M.C., Lu W.W., Luk K.D.K., Liu X.M. and |
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Chan
Y.L., Yeung K.W.K., Lu W.W., Ngan A.H.W., Luk K.D.K., Chan D., Wu S.L., Liu X.M., |
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Cheah K.S.E., Au Y.K., Wynn S.L., Geng G.Y.H. and Cheung K.M.C., Insight into the molecular pathogenesis of campomelic dysplasia revealed by a conditional Sox9 mutant mouse model. , Cold Spring Harbor Meeting on Mouse Molecular Genetics, Cold Spring Harbor, 30 Aug - 3 Sept 2006 New York, USA. 2006. |
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Cheung
K.M.C., Animal models of intervertebral disc
regeneration, Stem Cell Workshop, Faculty of Medicine, The |
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Cheung
K.M.C., Assessment and treatment of pyogenic
and tuberculous infections of the spine, Worldwide Regional Course, |
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Cheung K.M.C., Chan D., Karppinen J., Chen Y.Q., Jim J.J.T., Yip S.P., Ott J., Wong K.K., Sham P.C., Luk K.D.K., Cheah K.S.E., Leong J.C.Y. and Song Y., Association of the Taq I allele in vitamin D receptor with degenerative disc disease and disc bulge in a Chinese population, Spine. 2006, 31(10): 1143-1148. |
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Cheung
K.M.C., C5-6 disc prolapse with myelopathy.
Anterior cervical diskectomy and bone only fusion, 13th APOA Operative
Spine Course, |
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Cheung K.M.C., Fan B., Karppinen J., Leong J.C.Y. and Luk K.D.K., Can age-related interverterbal disc changes be differentiated from degenerative disc disease?, 34th Annual Meeting of International Society for the Study of the Lumbar Spine, Hong Kong, June 10-14, 2007. |
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Cheung K.M.C., Bullmann V., Senkoylu A., Halm H.F.H., Wong Y.W., Luk K.D.K. and Liljenqvist U.R., Comparative sagittal plane correction after anterior single rod versus dual rod instrumentation in idiopathic thoracolumbar and lumbar scoliosis, 41st Annual Meeting of the Scoliosis Research Society, Monterey, California, September 13-16, 2006. |
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Cheung
K.M.C., Degenerative and defomrity: disc
degeneration / regeneration, AOSpine Interactive Course, |
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Cheung
K.M.C., Degenerative and deformity: Spondylolisthesis,
AOSpine Interactive Course, |
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Cheung K.M.C., Enhancing bioactivity and corrosion resistance of NiTi using plasma immersion ion implantation , International Conference on Metallurgical Coatings and Thin Films, San Diego, USA, April 23-27, 2007. |
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Cheung
K.M.C., Genetics of degenerative disc
disease, 8th Physiatric Summer School organised by the Society for Back
Pain Research in |
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Cheung K.M.C., Luk K.D.K., Ho D.W.H., Chan D., Cheah K.S.E. and Song Y., Linkage analysis on familial early-onset degenerative disc disease. , Best Poster Award. 34th Annual Meeting of International Society for the Study of the Lumbar Spine, Hong Kong. 2007. |
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Cheung
K.M.C., Management of post-infectious
kyphotic deformities, Worldwide Regional Course, |
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Cheung
K.M.C., Management of severe paediatric
scoliosis, 4th Hong Kong International Orthopaedic Forum, |
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Cheung
K.M.C., Management of severe scoliosis in
young children, 1st International Congress of Chinese Orthopaedic
Association, |
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Cheung
K.M.C., Cheung
K.M.C. and Cheung K.M.C.,
Natural history and classification - are they useful?, 13th APOA Operative
Spine Course, |
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Cheung
K.M.C., New options in motion preservation:
biologic intervertebral disc replacement, 8th Physiatric Summer School
organised by the Society for Back Pain Research in |
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Cheung K.M.C. and Leung Y.L., Rebuilding the degenerated intervertebral discs by bone marrow stem cells, The Hong Kong Medical Diary. 2007, 12: 28. |
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Cheung
K.M.C., Karppinen J., Guo G.G., Fan B., Leong J.C.Y. and Luk K.D.K., Relationship Between MRI
Changes of The Lumbar Spine and Low Back Pain: A MRI Study of 1043
Population-Based Subjects., International Society for the Study of the
Lumbar Spine. 34th Annual Meeting. |
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Cheung K.M.C., Karppinen J., Guo G.G., Fan B., Leong J.C.Y. and Luk K.D.K., Relationship between MRI changes of the lumbar spine and low back pain: a MRI study of 1043 population-based subjects, 34th Annual Meeting of International Society for the Study of the Lumbar Spine, Hong Kong, June 10-14, 2007. |
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Cheung
K.M.C., Cheng A.C.S., Cheung W.Y., Chooi Y.S., Wong Y.W. and Luk K.D.K., Right hip adduction deficit
is prevalent in patients with adolescent idiopathic scoliosis, 26th Annual
Congress of the Hong Kong Orthopaedic Association, |
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Cheung K.M.C., Yeung K.W.K., Chung J.C.Y. and Lu W.W., Shape memory material and method of making the same, Japan Non-Provisional Patent No. 2006-523770 filed October 19, 2006. 2006. |
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Cheung
K.M.C., Spondylolysis L5, pars repair, 13th
APOA Operative Spine Course, |
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Cheung
K.M.C., Song
Y., Kao P.Y.P., Ho D.W.H., Fan B., Karppinen J., Yip S.P., Cheong J.C.Y.,
Luk K.D.K., Ott J., Cheah K.S.E., Sham P.C. and Chan D., Three genes in the aggrecan
degradation pathway act synergistically to predispose to degenerative disc
disease., International Society for the Study of the Lumbar Spine. 34th
annual Meeting, June 10-14, 2007 |
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Cheung K.M.C., Song Y., Kao P.Y.P., Ho D.W.H., Fan B., Karppinen J., Yip S.P., Leong J.C.Y., Luk K.D.K., Ott J., Cheah K.S.E., Sham P.C. and Chan D., Three genes in the aggrecan degraduation pathway act synergistically to predispose to degenerative disc disease, 34th Annual Meeting of International Society for the Study of the Lumbar Spine, Hong Kong, June 10-14, 2007. |
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Cheung
K.M.C., Trauma and tumor: disc degeneration /
regeneration, AOSpine Interactive Course, |
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Cheung
K.M.C., Trauma and tumor: introduction course
and ARS, AOSpine Interactive Course, |
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Cheung K.M.C., Tuberculosis spine - current state of art, The Conjoint Scientific Congress organised by RCSE and CSHK, Hong Kong, October 12, 2006. 2006. |
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Cheung
K.M.C., cervical spine: disc degeneration /
regeneration, AOSpine Interactive Course, |
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Cheung
K.M.C., thoracolumbar spine: disc
degeneration / regeneration, AOSpine Interactive Course, |
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Cheung W.Y., Wong Y., Cheung K.M.C., Wong Y.W. and Luk K.D.K., Fulcrum bending correct rotational deformity in adolescent idiopathic scoliosis, 26th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 11-12, 2006. |
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Guo
X., Irwin M.G., Chan D., Tipoe G.L. and Cheung K.M.C., The Role of
Cyclooxygenase 1 and |
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Ho D.W.H., Cheung K.M.C., Chan D., Karppinen J., Yip S.P., Ott J., Luk K.D.K., Leong J.C.Y., Cheah K.S.E., Sham P.C. and Song Y., Linkage Analysis on Familial Early-Onset Degenerative Disc Disease (DDD)., ABS#apbc056 Jan14-17. 2007. |
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Ho D.W.H., Cheung K.M.C., Chan D., Karppinen J., Yip S.P., Ott J., Luk K.D.K., Leong J.C.Y., Cheah K.S.E., Sham P.C. and Song Y., Linkage analysis on familial early onset degenerative disc disease, 34th Annual Meeting of International Society for the Study of the Lumbar Spine, Hong Kong, June 10-14, 2007. |
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Ho J.P.Y., Wu S.L., Poon R.W.Y., Chung
C.Y., |
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Hui
T.Y., Chan D., Cheung K.M.C., Chan G.C.F., Cheung W.L. and Chan B.P., Chondrogenic differentiation
of human mesenchymal stem cells in three-dimensional
collagen/chondroitin-6-sulfate gels: Influences of cell seeding density and
collagen concentration, International Society for Stem Cell Research 5th
Annual Meeting. Jun 15-21 2007. |
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Kao
P.Y.P., Sham P.C., Chan D., Cheung K.M.C. and Song Y., Investigating Epistasis in
Degenerative Disc Disease., 11th Research Postgraduate Symposium, 7 Dec.
2006. The |
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Kao P.Y.P., Chan D., Cheung K.M.C., Cheah K.S.E., Sham P.C. and Song Y., Investigating Epistasis in Degenerative Disc Disease., ABS#apbc101 Jan 14-17, 2007. |
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Lam
R.W.M., Cheung K.M.C., Lu W.W., Luk K.D.K. and Wong C.T., Bone Composition and Crystal
Structure after Strontium Treatment for Osteoporosis Goat Model. , Young
Investigator Award, 8th Regional Osteoporosis Conference, The Osteoporosis
Society of |
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Leong
V.Y.L., Hung S.C., Tsui Y.K., Lee M.K., Li L.C., Lo G.G., Masuda K.,
Wu E.X., Luk K.D.K., Chan D. and Cheung K.M.C., Allogenic Mesenchymal
Stem Cell Transplantation Into The Intervertebral Disc: Effect Of Severity Of
Degeneration And Cell Number On Regeneration , International Society for
the Study of the Lumbar Spine. 34th Annual Meeting. |
|
Leung
H.B., Tseng H., Lu W.W., Cheung K.M.C. and Luk K.D.K., Pullout strength of screws
from bioactive bone cement versus polymethylmethacrylate bone cement, 26th
Annual Congress of the Hong Kong Orthopaedic Association, |
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Leung V.Y.L., Ho G., Chan D. and Cheung K.M.C., The effect of severity of degeneration on intervertebral disc regeneration by autologous mesenchymal stem cells, 25th Annual Congress of the Hong Kong Orthopaedic Association, Nov 19-20 2005, Hong Kong. 2006. |
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Leung Y.L., Wu E.X., Luk K.D.K., Chan D. and Cheung K.M.C., Allogeneic mesenchymal stem cell transplantation into the intervertebral disc: effect of severity of degeneration and cell number on regeneration, The Annual Meeting of the International Society for the Study of the Lumbar Spine. 2007. |
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Leung Y.L., Wu E.X., Luk K.D.K., Chan D. and Cheung K.M.C., Regeneration of degenerated intervertebral disc using allogeneic Mesenchymal stem cells encapsulated in self-assembling peptide hydrogel, 53rd Annual Meeting of the Orthopaedic Research Society. 2007. |
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Li Z., Lam R.W.M., Yang C., Xu B., Ni G., Abbah S.A., Cheung K.M.C., Luk K.D.K. and Lu W.W., Chemical composition, crystal size and lattice structural changes after incorporation of strontium into biomimetic apatite, Biomaterials. 2007, 28(7): 1452-60. |
|
Liu X., Wu S., Chan Y.L., |
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Liu X.M., Wu S.L., |
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Liu X.M., Wu S.L., |
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Poon A.M.S., Cheung K.M.C., Lu D. and Leong J.C.Y., Changes in melatonin receptors in relation to the development of scoliosis in pinealectomized chickens, Spine. Lippincott Williams & Wilkins, Inc, 2006, 31: 2043-2047. |
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Senkoylu
A., Wong Y.W., Luk K.D.K. and Cheung K.M.C., Prognosis of
spontaneous thoracic curve correction after the isolated anterior fusion of
Lenke |
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Song Y., Cheung K.M.C., Ho D.W.H., Chiba K., Kawaguchi Y., Hirose Y., Alini M., Yee A.F.Y., Poon S.C.S., Leong J.C.Y., Luk K.D.K., Yip S.P., Karppinen J., Cheah K.S.E., Sham P.C., Ikegawa S. and Chan D., Association of the Asporin D14 allele to lumbar disc degeneration in Chinese and Japanese., Gordon Research Conference on Cartilage Biology and Pathology, March 4-9, 2007, Ventura, CA, USA. 2007. |
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Song
Y., Cheung K.M.C., Fan B., Karppinen J., Yip S.P., Leong J.C.Y.,
Luk K.D.K., Ott J., Cheah K.S.E., Sham P.C. and Chan D., SNP-SNP Interaction in
Intervertebral Disc Disease with Genes in the Aggrecan Degradation Pathway, The
8th International Meeting on Human Genome Variation and Complex Genome
Analysis. Le Meridien Cyberport Hotel and Convention Centre, Hong Kong SAR, |
|
Soon H.C., Cheung K.M.C., Bullmann V., Senkoylu A., Halm H.F., Wong Y.W., Liljenqvist U.R. and Luk K.D.K., Comparative sagittal plane correction after anterior single rod versus dual rod instrumentation in idiopathic thoracolumbar and lumbar scoliosis, 26th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 11-12, 2006. |
|
Tong
H.W., Wang M., Lu W.W., Cheung K.M.C., Yeung K.W.K. and Luk K.D.K., Pedicle screws and rods made
of a shape memory alloy for treating scoliotic patients, Proceedings of
the Biomedical Engineering Conference BME2006. |
|
Tsang K.Y., Chan D., Cheslett D., Chan W.C.W., So C.L., Melhado I.G., Chan W.Y., Kwan K.M., Hunziker E.B., Yamada Y., Bateman J.F., Cheung K.M.C. and Cheah K.S.E., Surviving ER Stress is Coupled to Altered Chondrocyte Differentiation and Function., PLoS Biology. 2007, 5(3): 44. |
|
Virtanen I.M., Song Y., Cheung K.M.C., Ala-Kokko L., Karppinen J., Ho D.W.H., Luk K.D.K., Yip S.P., Leong J.C.Y., Cheah K.S.E., Sham P.C. and Chan D., Phenotypic and Population Differences in the Association between CILP and Lumbar Disc Disease., Journal of Medical Genetics. 2007, 44(4): 285-8. |
|
Wong T.F., Chow D.H., Holmes A.D. and Cheung K.M.C., The feasibility of repositioning ability as a tool for ergonomic evaluation: effects of chair back inclination and fatigue on head repositioning, Ergonomics. 2006, 49(9): 860-873. |
|
Wong
Y.W., Cheung K.M.C. and Luk K.D.K., Acute spinal cord or cadua
equina compression by epidural hematoma: review of 7 cases, 26th Annual
Congress of the Hong Kong Orthopaedic Association, |
|
Wu S.L., Chung C.Y., Liu X.M., |
|
Yang
F., Cheung K.M.C., Lu W.W., Leung Y.L., Chan D. and Luk K.D.K., A Simple Annular Puncture
Model Of Disc Degeneration In The Mouse Tail, International Society for
the Study of the Lumbar Spine. 34th Annual Meeting. |
|
Yang
F., Chan D., Leong V.Y.L., Lu W.W., Luk K.D.K. and Cheung K.M.C., A Simple Novel
Annular Puncture Model of Disc Degeneration in the Mouse Tail., 11th
Research Postgraduate Symposium, 7 Dec. 2006. The |
|
Yee
A.F.Y., Cheung K.M.C. and Chan D., Protein Expression Profiles of
the Intervertebral Disc., 11th Research Postgraduate Symposium, 7 Dec.
2006. The |
|
Yeung K.W.K., Lu W.W., Luk K.D.K. and Cheung K.M.C., A novel "smart" spinal impact locking mechanism based on nickel-titanium alloy., Spine. 2006, 31(20): 2296-2303. |
|
Yeung
K.W.K., Chan Y.L., Lam K.O., Liu X.Y., Chung C.Y., |
|
Yeung
K.W.K., Poon R.W.Y., Chung C.Y., Liu X.Y., |
|
Yeung
K.W.K., Wu S.L., Liu X.M., Chung C.Y., |
|
Yeung
K.W.K., Lam K.O., Chan Y.L., Wu S.L., Liu X.Y., Chung
C.Y., |
|
Yeung
K.W.K., Chan Y.L., Lam K.O., Liu X.Y., Chung C.Y., |
|
Yeung M.Y., Smith D.K., Chan S.Y., Wong B.C.W., Cheung K.M.C., Cheah K.S.E., Sham P.C., Chan D. and Song Y., iCartiGD: Integrated Cartilage Gene Database for genetic study of cartilage, BMC Genetics . 2007, 8: 4. |
|
Yeung M.Y., Smith D.K., Chan S.Y., Wong B.C.W., Cheung K.M.C., Cheah K.S.E., Sham P.C., Chan D. and Song Y., iCartiGD:The Integrated Cartilage Gene Database., The Integrated Cartilage Gene Database. 2007. |
|
Zhou
G., Yee A.F.Y., Chan D., Alini M. and Cheung K.M.C., Hypoxia-related and
Stem Cell-Like Phenotypes of Young, Adult and Aged Intervertebral Disc Cells,
International Society for the Study of the Lumbar Spine. 34th Annual
Meeting. |
|
List of Research Outputs |
|
Cheung
K.M.C., Cheng A.C.S., Cheung W.Y.,
Chooi Y.S., Wong Y.W. and Luk K.D.K., Right hip adduction deficit
is prevalent in patients with adolescent idiopathic scoliosis, 26th Annual
Congress of the Hong Kong Orthopaedic Association, |
|
Cheung W.Y., Wong Y., Cheung K.M.C., Wong Y.W. and Luk K.D.K., Fulcrum bending correct rotational deformity in adolescent idiopathic scoliosis, 26th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 11-12, 2006. |
|
Cheung W.Y., Surgical interventions for ankylosing spondylitis, The Hong Kong Medical Diary. 2006, 11(11): 11-13. |
|
Yeung Y., Chiu P.K.Y., Yau P.W.P., Tang W.M., Cheung W.Y. and Ng T.P., Assessment of the proximal femoral morphology using plain radiograph - can it predict the bone quality?, The Journal of Arthroplasty. 2006, 21(4): 508-513. |
|
Project Title: |
The effect of bisphosphonate on established osteolytic lesions--a study of different approach and dosage in rabbit hip replacement model |
|
Investigator(s): |
|
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2003 |
|
Abstract: |
|
To study the effect of different approach and dosage of bisphosphonate on bone loss in previous established rabbit osteolysis model after hip joint replacement. |
|
List of Research Outputs |
|
Cheung K.W., Yau P.W.P., Chiu K.H. and Chiu P.K.Y., Navigated high tibial
osteotomy with Vector Vision system., Stiehl JB, Konermann W, Haaker R,
DiGioia (Editors): "Navigation and MIS in Orthopaedic Surgery",
Springer Verlag, Berlin, Heidelberg. Springer Verlag, |
|
Chiu P.K.Y., 1. Instructional Course Lecture: Diagnosis and treatment of infection after THA 2. Guest lecture: Revision TKA, Eighth National Congress of Orthopaedic Surgery and The First International Congress of Chinese Orthopaedic Association, organized by Chinese Medical Association and Chinese Orthopaedic Association, November 13-15, 2006 at Beijing, China. 2006. |
|
Chiu
P.K.Y., Computer helps my every knee
replacement - in the affirmative, |
|
Chiu
P.K.Y., Pitfalls in TKA, The 1st
International Macau Orthopaedic Forum organized by the Macau Orthopaedic
Association, September 24, 2006 at Macau, |
|
Ng F.Y., Zhu Y. and Chiu P.K.Y., Cementless acetabular component inserted without screws - the effect of immediate weight bearing , International Orthopaedics. 2007, 31: 293-296. |
|
Ng F.Y., Wong H.L., Yau A.C.M.C. and Chiu P.K.Y., Range of motion of
standard and high-flexion posterior stabilized total knee prosthesis, The
26th Annual Congress of the Hong Kong Orthopaedic Association, |
|
Ng F.Y., Wong H.L., Yau P.W.P. and Chiu P.K.Y., Range of motion of standard and high-flexion posterior stabilized total knee prosthesis, The Eighth National Congress of Orthopaedic Surgery and the First International Congress of Chinese Orthopaedic Association, November 13-15, 2006. 54. |
|
Ng T.P., Lai A., Wong L., Ting A.C.W. and Chiu P.K.Y., Unusual cause of deep vein thrombosis - Iliopsoas bursa compressing the femoral vein, The 26th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2006, 10: S93. |
|
Ni G., Lu W.W., XU B., Chiu P.K.Y., Yang C., Li Z., Lam R.W.M. and Luk K.D.K., Interfacial behaviour of strontium-containing hydroxyapatite cement with cancellous and cortical bone, Biomaterials. 2006, 27: 5127-5133. |
|
Ni G., Chiu P.K.Y., Lu W.W., Wang Y., Zhang Y.G., Hao L., Li Z., Lam R.W.M. and Luk K.D.K., Strontium-containing hydroxyapatite bioactive bone cement in revision hip arthroplasty, Biomaterials. 2006, 27: 4348-4355. |
|
Ning C., Wang Y., Lu W.W., Qiu Q.X., Lam R.W.M., Chen X.F., Chiu P.K.Y., Ye J.D., Wu G., Wu Z.H. and Chow S.P., Nano-structural bioactive gradient coating fabricated by computer controlled plasma-spraying technology , Journal of Materials Science. Materials in Medicine. 2006, 17(10): 875-884. |
|
Tang
W.M. and Chiu P.K.Y.,
Avascular Necrosis in SARS , RCSE & CSHK Conjoint Scientific Congress,
12 October, 2006, |
|
Tang W.M. and Chiu P.K.Y., Classification of TKA implants, Yantai Joint Replacement Course 2006. 2006. |
|
Tang W.M. and Chiu P.K.Y., Knee Biomechanic, Yantai Joint Replacement Course 2006. 2006. |
|
Tang W.M. and Chiu P.K.Y., Revision TKA, Yantai Joint Replacement Course 2006. 2006. |
|
Tang W.M., Chiu P.K.Y., Kwan M.F.Y. and Ng T.P., Sagittal pelvic mal-rotation and positioning of the acetabular component in total hip arthroplasty: three-dimensional computer model analysis, Journal of Orthopaedic Research. 2007, 25(6): 766-771. |
|
Yan C.H., Yau P.W.P., Ng T.P., Lie W.H., Chiu P.K.Y. and Tang W.M., Inter-observer and intra-observer errors in obtaining transepicondylar axis and Whiteside line in total knee arthroplasty, The 26th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2006, 10: S99. |
|
Yan C.H., Yau P.W.P., Ng T.P., Lie W.H., Chiu P.K.Y. and Tang W.M., Inter-observer and intra-observer errors in obtaining transepicondylar axis and Whiteside line in total knee arthroplasty, The Eighth National Congress of Orthopaedic Surgery and the First International Congress of Chinese Orthopaedic Association, November 13-15, 2006. 56. |
|
Yau P.W.P., Chiu P.K.Y., Tang W.M. and Ng T.P., Coronal bowing of the femur and tibia in Chinese: Its incidence and effects on total knee arthroplasty planning, Journal of Orthopaedic Surgery. 2007, 15: 32-36. |
|
Yau
P.W.P., Leung A., Liu K.G., Yan C.H., Wong L.L.S. and Chiu P.K.Y., Errors in obtaining
visually selected anatomical landmarks during registration process in
non-image based navigation assisted TKR: Comparison between minimal incision
approach and conventional incision approach , 29th Annual Congress of
Singapore Orthopaedic Association -"Frontiers in spinal surgery,
paediatric orthopaedics and cartilage regeneration." November 8-11,
2006, |
|
Yau
P.W.P., Leung A., Liu K.G., Yan C.H., Wong L.L.S. and Chiu P.K.Y., Errors in obtaining
visually selected anatomical landmarks during registration process in
non-image based navigation assisted TKR: Comparison between minimal incision
approach and conventional incision approach, 29th Annual Congress of |
|
Yau
P.W.P., Chiu P.K.Y. and Tang W.M., Factors affecting the
alignment of the implanted prosthesis in computer navigation total knee
replacement. How precise is the determination of rotational alignment of the
femoral prosthesis in total knee replacement?, The 4th Annual Meeting of
Aisan Society for Computer Assisted Orthopaedic Surgery, March 30-31, 2007, |
|
Yau P.W.P., Chiu P.K.Y., Tang W.M. and Ng T.P., Factors affecting the alignment of the implanted prosthesis in computer navigation total knee replacement, The 4th Annual Meeting of Asian Society for Computer Assisted Orthopaedic Surgery, March 30-31, 2007, Seoul, Korea. 2007. |
|
Yau
P.W.P., Chiu P.K.Y. and Tang W.M., How precise is the
determination of rotational alignment of the femoral prosthesis in total knee
replacement?, The 4th Annual Meeting of Asian Society for Computer
Assisted Orthopaedic Surgery. March 30-31, 2007, |
|
Yau
P.W.P., Chiu P.K.Y., Tang W.M. and Ng T.P., The residual posterior femoral
condyle osteophyte - Will it affect flexion range after total knee
arthroplasty, 6th Annual Scientific Symposium. Orthopaedic Update:
"Clinical options for younger patients". January 10-13, 2007, |
|
Yeung Y. and Chiu P.K.Y., Letter to editor: Assessment of the proximal femoral morphology using plain radiograph - Can it predict the bone quality?, Journal of Arthroplasty. 2007, 22: 297. |
|
Yeung Y., Chiu P.K.Y., Yau P.W.P., Tang W.M., Cheung W.Y. and Ng T.P., Assessment of the proximal femoral morphology using plain radiograph - can it predict the bone quality?, The Journal of Arthroplasty. 2006, 21(4): 508-513. |
|
Zhang B.S., He L., Wang M.Y. and Chiu P.K.Y., An experimental study on biomechanical effect of cemented intramedullary stem tip on bone torsional property at the level of femoral cortical screw holes, 髓內骨水泥柄對伴有骨缺損的長管狀骨生物力學的影響, Chinese Journal of Orthopaedic Trauma . 中華創傷骨科雜誌, 2007, 9(2): 162-164. |
|
Zhang J.X., Woo J., Lau W.C.S., Lee P.W.H., Chiu P.K.Y. and Lam D., Effects of use of alternative therapies on quality of life and healthcare spending, The American Journal of Chinese Medicine. 2007, 35: 183-193. |
|
Researcher
: Chooi YS |
|
List of Research Outputs |
|
Cheung
K.M.C., Cheng A.C.S., Cheung W.Y.,
Chooi Y.S., Wong Y.W. and Luk K.D.K., Right hip adduction deficit
is prevalent in patients with adolescent idiopathic scoliosis, 26th Annual
Congress of the Hong Kong Orthopaedic Association, |
|
Researcher
: Chow SP |
|
Project Title: |
Novel prosthetic replacements for metacarpophalangeal (MCP) joints |
|
Investigator(s): |
Chow SP, Ngan AHW, |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2005 |
|
Abstract: |
|
To reproduce the anatomical shape in order to achieve a good range of movement and to interact with the soft tissue in achieving the necessary stability; to have the right material for both the surface and the stem of the implant. |
|
Project Title: |
An animal model for vascularised nerve graft in complete spinal cord transection |
|
Investigator(s): |
Chow SP, |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
01/2006 |
|
Abstract: |
|
Objectives :To establish an aminal model where a vascularised nerve graft can be used to bridge a complete transection of the spinal cord.Key issues and problem being addressed :In the past 20 years or so, attempts to achieve regeneration of the spinal cord across a defect left after spinal cord injury were directed towards three aspects :-a. To promote regeneration of the nerves by various active substances such as growth factorsb. To neutralise the inhibitors of regenerationc. To bridge the gap with all kinds of conduits and cells.The use of the peripheral nerve graft, which is highly successful in the peripheral nervous system, may be able to help bridge the gap, provide growth factors, or even neutralize the inhibitors. Indeed, Cajal, Kao, Wardrope, Cheng had all tried to use peripheral nerve grafts in different ways, yet only with rather feeble regeneration. One of the reasons for their failure, perhaps, was the lack of a good blood supply of the transplanted nerve graft in the environment of the spinal canal where the bony and ligamentous surrounding and the CSF were not conducive to re-vascularisation, thus leading to necrosis and fibrosis of the grafts. The use of vascularise nerve grafts (VNG) may therefore open up a new approach in spinal cord regeneration.The principal investigator had explored the use of VNG in spinal cord injury in the rat. A graft of the median and ulnar nerve of the upper limb was harvested with a long pedicle of blood vessl and was directed towards a defect of the spinal cord at the cervico-dorsal junction. Initially, a total transection of the cord was created, but all the animals died. Even with a hemi-transection model, 50% of the animal died unless very careful post-operative care was instituted. The subsequent study of the regeneration through the graft had to be carried out with the remaining intact half completely divided in order to show neurotransport and electrical conduction across the grafts. Extremely painstaking care and highly demanding technique was required. With such an amimal model, it was possible to show extraordinary good regeneration into the graft when compared to non-vascularised free nerve grafts (FNG).This animal model with a hemi-resection of the spinal cord, however, is open to all kinds of criticism. It will be ideal to develop an animal model where a VNG can be used to bridge a complete transection of the spinal cord.In trying to establish a VNG for a complete transection of the spinal cord, it is almost certain that the only feasible site for a complete cord transection in the animal has to be performed below the mid-thoracic level as a higher level will incur an extremely high mortality rate. In this area, vascularised nerve grafting post 2 major problems :-(1) Initial exploration showed that pedicled nerve graft from both the upper limb and the lower limb could not reach this area in the rat and rabbit.(2) If free vascularised grafts are used, the recipient blood vessels are too small for microvascular anatomosis even in the rat. |
|
List of Research Outputs |
|
Chow S.P., A novel artificial prosthetic replacement for the proximal interphalangeal (PIP) joint of the hand - From concept to prototype, The 6th Congress of the Asian Pacific Federation of Societies for Surgery of the Hand, Bangkok, Thailand, 15-18 November 2006 . 2006. |
|
Chow S.P., A novel artificial prosthetic replacement for the proximal interphalangeal joint of the hand, 10th Triennial Congress of the International Federation of Societies for Surgery of the Hand (IFSSH), Sydney, Australia, 11-15 March 2007. |
|
Chow S.P., Experience of developing a novel artificial finger joint, 10th Triennial Congress of the Chinese Society for Surgery of the Hand, Beijing, PR China, 24-27 May 2007. |
|
Chow
S.P., Finger amputation and replantation, AO
Hand Course, |
|
Chow
S.P., Fragment specific plating for distal
radius, AO Hand Course, |
|
Chow
S.P., Intra-articular fractures distal radius
- treatment options, AO Hand Course, |
|
Chow
S.P., Metacarpal and phalangeal fractures, AO
Hand Course, Syndey, |
|
Chow
S.P., Planning osteotomies of metacarpal and
phalangeal malunions, AO Hand Course, |
|
Chow
S.P., Principles of LCP, AO Hand Course, |
|
Chow
S.P., Principles of lag screw, AO Hand
Course, |
|
Chow
S.P., Principles of lag screw, AO Hand
Course, |
|
Chow
S.P., The problems of present fixation
devices for distal radius fractures, Japanese Society for Surgery of the
Hand Congress, |
|
Garg R., Fung B.K.K., Chow S.P. and Ip W.Y., A free thenar flap - a case report, Journal of Orthopaedic Surgery and Research. 2007, 12: 2-4. |
|
Ip W.Y., Chow S.P., Fung B.K.K. and Garg R., Treating deep-seated mycobacterium marium infection in the hand: a report of three cases, Hand Surgery. 2006, 11(1&2): 83-88. |
|
Lau T.W., Leung K.L., Chan C.F. and Chow S.P., Minimally invasive plate fixation of proximal humeral fractures, The 26th Hong Kong Orthopaedic Association Annual Congress, Hong Kong, 11-12 November 2006, . 2006. |
|
Leung K.L., Gudushauri P., Fung B.K.K. and Chow S.P., Arthroscopic assessment of soft tissue injuries in comminuted intra-articular fractures of the distal radius, Chinese Journal of Orthopaedic Trauma. 2006, 8(3): 203-207. |
|
Leung K.L. and Chow S.P., Locking compression plate in the treatment of forearm fractures: a prospective study, Journal of Orthopaedic Surgery. 2006, 14(3): 291-294. |
|
Leung
K.L. and Chow S.P.,
Reduction techniques, AO Manual of Fracture Management - Minimally
invasive plate osteosynthesis (MIPO). |
|
Lu W.W., Zhu L., Ni G., Leung K.L. and Chow S.P., Five fixation methods for unstable intra-articular fractures of the distal radius: an in vitro biomechanical study using cadaveric model, Chinese Journal of Orthopaedic Trauma. 2006, 8(3): 208-211. |
|
Ning C., Wang Y., Lu W.W., Qiu Q.X., Lam R.W.M., Chen X.F., Chiu P.K.Y., Ye J.D., Wu G., Wu Z.H. and Chow S.P., Nano-structural bioactive gradient coating fabricated by computer controlled plasma-spraying technology , Journal of Materials Science. Materials in Medicine. 2006, 17(10): 875-884. |
|
Researcher
: Fang D |
|
List of Research Outputs |
|
Fang
D. and Tang
W.M., The world is In need of an Asian Knee., The 26th Annual Congress
of Hong Kong Orthopaedic Association, |
|
Researcher
: Fung BKK |
|
List of Research Outputs |
|
Fung
B.K.K., Chan K.Y., Lam L.Y., Cheung S.Y.,
Choy N.K., |
|
Garg R., Fung B.K.K., Chow S.P. and Ip W.Y., A free thenar flap - a case report, Journal of Orthopaedic Surgery and Research. 2007, 12: 2-4. |
|
Ip W.Y., Chow S.P., Fung B.K.K. and Garg R., Treating deep-seated mycobacterium marium infection in the hand: a report of three cases, Hand Surgery. 2006, 11(1&2): 83-88. |
|
Leung K.L., Gudushauri P., Fung B.K.K. and Chow S.P., Arthroscopic assessment of soft tissue injuries in comminuted intra-articular fractures of the distal radius, Chinese Journal of Orthopaedic Trauma. 2006, 8(3): 203-207. |
|
Wong J.Y.P., Fung B.K.K., |
|
Researcher
: Hao L |
|
List of Research Outputs |
|
Ni G., Chiu P.K.Y., Lu W.W., Wang Y., Zhang Y.G., Hao L., Li Z., Lam R.W.M. and Luk K.D.K., Strontium-containing hydroxyapatite bioactive bone cement in revision hip arthroplasty, Biomaterials. 2006, 27: 4348-4355. |
|
Researcher
: Hu Y |
|
Project Title: |
A Sensor Array Approach to Spatial Presentation on Surface Electromyography of Intra-muscular Pain Behaviour |
|
Investigator(s): |
Hu Y, Luk KDK |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
04/2006 |
|
Abstract: |
|
The objectives of this study are 1) to develop new methodology of myoelectric signal acquisition, decomposition and processing in sensor array sEMG for discovering and exploration of in-vivo functional physiology of muscle, 2) to characterise and compare the in-vivo motor unit firing behaviour and coordination processes corresponding to the actual pathophysiological status; and 3) to investigate the pain behaviour and electrophysiology of neuromuscular system in healthy, myopathic, spinal cord compression, and nerve root compression condition. Pain is the most common clinical symptom in various pathological conditions, which usually affects neuromuscular electrophysiological patterns. However, the pathomechanism of the effect of pain on neuromuscular activation potential distribution and their coordination behavior are still unclear. The key issus of this study is to find various myoelectrical activity patterns of the insulted muscle area, which will establish a reliable model to simulate the pain effcts on muscle activation and muscle contraction behaviour. |
|
Project Title: |
Novel method for fast extraction and auto-recognition of somatosensory evoked potentials |
|
Investigator(s): |
Hu Y, Luk KDK, |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2007 |
|
Abstract: |
|
(1) Purpose of investigation:
Intraoperative spinal cord monitoring can significantly minimize the risks of
iatrogenic injury to spinal cord during spinal surgery, neurosurgery and
aortic surgery. Somatosensory evoked potential (SEP) is the most popular
technique currently being used in the operating room. The ensemble averaging
method (EA) is the only practical method to extract SEP, but it will
considerably lengthen the surgical time and hinder the surgical procedures,
and more importantly, it cannot provide the spine surgeon with a timely
warning of the eminent danger of cord injury. This motivates us to study and
develop a new and improved method for fast extraction and automatic
recognition of SEP.(2) Key issues and major problems: The main problem in SEP
monitoring is its extremely low signal to noise ratio (SNR) and variability
in its signal waveform. The EA method is used to extract SEP from background
noise, but it is time-consuming. Moreover, the noisy waveform makes the
auto-recognition of abnormal changes in SEP a difficult task. Sometimes,
latency/amplitude measurement based on time-domain SEP waveform is highly
variable.(3) Objectives and Possible outcomes: This project has 3 main
objectives: i) To study and develop a signal processing technique for
improving the SNR of SEP signals. We shall study and apply a multi-adaptive
filter in combination with a novel data-reusing non-linear method based on
radial basis function neural network (RBFNN) for improving the SNR of SEP
signals. (4) ii) To study and develop a fast extraction method for separating
the SEP signal from other interference based on multi-channel blind source
separation. The use of a multi-adaptive filter can improve the SNR of SEP
signals, but it may not be sufficient to obtain a reliable SEP signal by a
single trial. The multi-channel blind source separation (BSS) will be used to
enhance the performance of the algorithm so that a more reliable and
reproducible SEP can be obtained from every single trial. Moreover, the
time-frequency feature of SEP will be investigated to establish a
time-frequency model for auto-classification and identification of SEP
waveform. (5) iii) To investigate and develop an auto-recognition method
based on time-frequency analysis of SEP. The developed fast extraction and
auto-recognition methods will be applied to clinical and animal experiments
and the specificity and sensitivity can be then evaluated. (6) Long-term
impact, relevance, significance and value: The findings of this research will
contribute to the further development of fast and reliable techniques for SEP
monitoring. The ultimate goal is to provide safer and more reliable
monitoring, which is more easy to carry out during surgery. In addition, the
results of this research would benefit the further development in SEP
diagnosis of neuromuscular disorders. On the engineering perspective, the
signal processing algorithms and results so developed will have considerable
impact on the theory and practice of multi-channel signal processing,
especially in neural engineering and electroencephalograph extraction. Last
but not least, the future application of this study can be developed into a
product with economical benefit for |
|
Project Title: |
7T fMRI study on a new rat model with chronic and progressive spinal cord compression |
|
Investigator(s): |
Hu Y, Luk KDK, Wu EX |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
03/2007 |
|
Abstract: |
|
To develop a new material based on water-absorbing polyurethane elastomer encased by sustained-release membrane, which can expand it volume under well control; to establish a new animal model of cervical spondylotic myelopathy with chronic and progressive compression to the spianl cord; to testify the feasibility and reliability of this new animal model by functional MRI, radiological and electrophysiological examination. Cervical spondylotic myelopathy (CSM) is a common spinal discorder caused by degeneration of the cervical spine, impairs motor and sensory functions insidiously and progressively. However, the exact pathophysiology and precise mechanisms of the disease process remains to be elucidated. The key issue and problem addressed here is the difficulty to reproduce the chronic spinal cord compress on animal model. This study is to establish a new animal modle with progressive compression on the cord in a controllable duration and designed profile. |
|
List of Research Outputs |
|
Hu Y., Leung H.B., Lu W.W. and Luk K.D.K., Consequence of Paraspinal Muscle after Spinal Fusion: An experimental Study, Stud Health Technol Inform. 2006, 123: 461-466. |
|
Hu
Y., Mak
J.N.F., Liu H. and Luk K.D.K., ECG Cancellation for Surface
Electromyography Measurement Using Independent Component Analysis, 2007
IEEE International Symposium on Circuits and Systems Proceedings. 2007, May. |
|
Hu Y., ISSLS Macnab/Larocca Research Fellowship Award of 2007, , International Society for the Study of the Lumbar Spine . 2007. |
|
Hu
Y., Mak
J.N.F., Lu W.W. and Luk K.D.K., Surface Electrography
Topography As An Assessment for Low Back Pain Rehabilitation, The 3rd
International IEEE EMBS Conference on Neural Engineeering. |
|
Mak
J.N.F., Hu Y. and Luk K.D.K., ICA-based ECG removal from
Surface Electrography and its effect on Low Back Pain Assessment, The 3rd
International IEEE EMBS Conference on Neural Engineeering. |
|
Tsui K.M., Zhang Z.G., Chan S.C., Hu Y. and Luk K.D.K., On the Time-frequency
Analysis of Trunk Muscles During Sudden Release of Load, 2007 IEEE
International Symposium on Circuits and Systems Proceedings. 2007, May. |
|
Tsui K.M., Zhang Z., Chan S.C., Hu Y. and Luk K.D.K., On the Time-frequency Analysis of Trunk Muscles During Sudden Release of Load, Proc. IEEE Int'l Symposium on Ciruits and Systems (ISCAS'2007). 2007, 1309-1312. |
|
Project Title: |
Study on wrist problems |
|
Investigator(s): |
Ip WY, Chow SP |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
01/1996 |
|
Abstract: |
|
To study the clinical problems of chronic wrist pain. The individual specific clinical problems including sequalae of fracture distal radius, carpal instability, distal radio-ulnar joint problems, triangular fibrocartilage complex lesions and ulnar abatment syndromes would be studied in details. The objectives are to find the best treatment methods and to improve the functional results. |
|
Project Title: |
The study of work related hand injuries in Hong Kong |
|
Investigator(s): |
Ip WY, Chow SP |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Occupational Safety and Health Council - Research Grant Projects |
|
Start Date: |
01/1998 |
|
Abstract: |
|
To study the epidemiology of severe hand injuries which are work related in Hong Kong Island; to suggest more accurate prognostic factors and more reasonable disability assessment system of hand injury; to give suggestions in industrial safety; to improve management of severe hand injuries; to minimise the social cost of severe hand injuries. |
|
Project Title: |
Use of bio-corrodible alloys for tissue engineering |
|
Investigator(s): |
|
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
10/2006 |
|
Abstract: |
|
The objective of this small project is to investigate the feasibility and the difficulties in the use of bio-corrodible alloys and their composites, particularly magnesium alloys and their composites, as a temporary implant material in the body when used in a significant amount, to facilitate the repairing of body tissues.Animal work will determine the "in vivo" compatibility of such biomaterials, and cell culture will suggest whether such alloys and composites can promote the growth of cells other than osteoblasts. Investigation on composites will suggest the research direction in the reduction or elimination of the gas evolved from the alloys and trapped under tissues. |
|
List of Research Outputs |
|
Garg R., Fung B.K.K., Chow S.P. and Ip W.Y., A free thenar flap - a case report, Journal of Orthopaedic Surgery and Research. 2007, 12: 2-4. |
|
Ip
W.Y., Clinical application of resorbable
polymer in guided bone regeneration, 10th Triennial Congress of the
Chinese Society for Surgery of the Hand, |
|
Ip W.Y., Clinical applications of resorbable polymenrs in Orthopaedic Surgery, American Society for Surgery of the Hand. 2006. |
|
Ip
W.Y., Clinical applications of resorbable
polymers in orthopaedic surgery , International Conference: Biomaterials
in Regenerative Medicine, |
|
Ip W.Y., Design and testing of novel artificial finger joint, Inaugural Congress of Southern Chinese Society for Surgery of the Hand, Shenzhen, PR China, 4-7 October 2006 . 2006. |
|
Ip W.Y., Flexor tendon injuries, The 6th Congress of the Asian Pacific Federation of Societies for Surgery of the Hand, Bangkok, Thailand, 15-18 November 2006. |
|
Ip
W.Y., Hand fractures, The 6th Congress of
the Asian Pacific Federation of Societies for Surgery of the Hand, |
|
Ip
W.Y., PIPJ injury, |
|
Ip
W.Y., Phalangeal and metacarpal hand
fractures, 10th Triennial Congress of the International Federation of
Societies for Surgery of the Hand, |
|
Ip
W.Y., Reconstruction of tetraplegic hand, |
|
Ip
W.Y., Surgical treatment of cerebral palsy, 20th
Annual Congress of Hong Kong Society for Surgery of the Hand, |
|
Ip W.Y., Chow S.P., Fung B.K.K. and Garg R., Treating deep-seated mycobacterium marium infection in the hand: a report of three cases, Hand Surgery. 2006, 11(1&2): 83-88. |
|
Ip
W.Y., Upper limb surgery in cerebral palsy, |
|
Yuen C.K. and Ip W.Y., The use of bio-corrodible alloys for tissue engineering, 11th Research Postgraduate Symposium, LKS Faculty of Medicine, HKU (Dec 2006) - Program & Abstract. 2006, 99. |
|
Zhou
W., Lee S.H., Cheung W.L., Wang M. and Ip W.Y., Selective laser sintering
of porous scaffolds from poly(L-lactide) microspheres and its nanocomposite
with carbonated hydroxyapatite nanospheres, Proceedings of 20th European
Conference on Biomaterials. |
|
Researcher
: Lam KO |
|
List of Research Outputs |
|
Yeung
K.W.K., Chan Y.L., Lam K.O., Liu X.Y., Chung C.Y., |
|
Yeung
K.W.K., Wu S.L., Liu X.M., Chung C.Y., |
|
Yeung
K.W.K., Lam K.O., Chan Y.L., Wu S.L., Liu X.Y., Chung
C.Y., |
|
Yeung
K.W.K., Chan Y.L., Lam K.O., Liu X.Y., Chung C.Y., |
|
Researcher
: Lam RWM |
|
List of Research Outputs |
|
Lam
R.W.M., Cheung
K.M.C., Lu W.W., Luk K.D.K. and Wong C.T., Bone Composition and Crystal
Structure after Strontium Treatment for Osteoporosis Goat Model. , Young
Investigator Award, 8th Regional Osteoporosis Conference, The Osteoporosis
Society of |
|
Li Z., Lam R.W.M., Yang C., Xu B., Ni G., Abbah S.A., Cheung K.M.C., Luk K.D.K. and Lu W.W., Chemical composition, crystal size and lattice structural changes after incorporation of strontium into biomimetic apatite, Biomaterials. 2007, 28(7): 1452-60. |
|
Ni G., Lu W.W., XU B., Chiu P.K.Y., Yang C., Li Z., Lam R.W.M. and Luk K.D.K., Interfacial behaviour of strontium-containing hydroxyapatite cement with cancellous and cortical bone, Biomaterials. 2006, 27: 5127-5133. |
|
Ni G., Chiu P.K.Y., Lu W.W., Wang Y., Zhang Y.G., Hao L., Li Z., Lam R.W.M. and Luk K.D.K., Strontium-containing hydroxyapatite bioactive bone cement in revision hip arthroplasty, Biomaterials. 2006, 27: 4348-4355. |
|
Ning C., Wang Y., Lu W.W., Qiu Q.X., Lam R.W.M., Chen X.F., Chiu P.K.Y., Ye J.D., Wu G., Wu Z.H. and Chow S.P., Nano-structural bioactive gradient coating fabricated by computer controlled plasma-spraying technology , Journal of Materials Science. Materials in Medicine. 2006, 17(10): 875-884. |
|
Researcher
: Lau TW |
|
List of Research Outputs |
|
Lau T.W., Leung K.L., Chan C.F. and Chow S.P., Minimally invasive plate fixation of proximal humeral fractures, The 26th Hong Kong Orthopaedic Association Annual Congress, Hong Kong, 11-12 November 2006, . 2006. |
|
Researcher
: Lee MK |
|
List of Research Outputs |
|
Leong
V.Y.L., Hung S.C., Tsui Y.K., Lee M.K., Li L.C., Lo G.G., Masuda
K., Wu E.X., Luk K.D.K., Chan D. and Cheung K.M.C., Allogenic Mesenchymal
Stem Cell Transplantation Into The Intervertebral Disc: Effect Of Severity Of
Degeneration And Cell Number On Regeneration , International Society for
the Study of the Lumbar Spine. 34th Annual Meeting. |
|
Researcher
: Leong JCY |
|
List of Research Outputs |
|
Abbah S.A., Lu W.W., Chan D., Cheung K.M.C., Liu W., Zhao F., Li Z., Leong J.C.Y. and Luk K.D.K., In vitro evaluation of alginate encapsulated adipose-tissue stromal cells for use as injectable bone graft substitute., Biochem Biophys Res Commun. 2006, 347(1): 185-91. |
|
Cheung K.M.C., Fan B., Karppinen J., Leong J.C.Y. and Luk K.D.K., Can age-related interverterbal disc changes be differentiated from degenerative disc disease?, 34th Annual Meeting of International Society for the Study of the Lumbar Spine, Hong Kong, June 10-14, 2007. |
|
Cheung K.M.C., Karppinen J., Guo G.G., Fan B., Leong J.C.Y. and Luk K.D.K., Relationship between MRI changes of the lumbar spine and low back pain: a MRI study of 1043 population-based subjects, 34th Annual Meeting of International Society for the Study of the Lumbar Spine, Hong Kong, June 10-14, 2007. |
|
Cheung K.M.C., Song Y., Kao P.Y.P., Ho D.W.H., Fan B., Karppinen J., Yip S.P., Leong J.C.Y., Luk K.D.K., Ott J., Cheah K.S.E., Sham P.C. and Chan D., Three genes in the aggrecan degraduation pathway act synergistically to predispose to degenerative disc disease, 34th Annual Meeting of International Society for the Study of the Lumbar Spine, Hong Kong, June 10-14, 2007. |
|
Ho D.W.H., Cheung K.M.C., Chan D., Karppinen J., Yip S.P., Ott J., Luk K.D.K., Leong J.C.Y., Cheah K.S.E., Sham P.C. and Song Y., Linkage analysis on familial early onset degenerative disc disease, 34th Annual Meeting of International Society for the Study of the Lumbar Spine, Hong Kong, June 10-14, 2007. |
|
Poon A.M.S., Cheung K.M.C., Lu D. and Leong J.C.Y., Changes in melatonin receptors in relation to the development of scoliosis in pinealectomized chickens, Spine. Lippincott Williams & Wilkins, Inc, 2006, 31: 2043-2047. |
|
Wong K.W.N., Luk K.D.K., Leong J.C.Y. and Lu W.W., Lumbar segmental motion patterns in patients with degenerative spondylolisthesis were detected with digital videofluoroscopic videos and distortion compensated Roentgen Analysis System, 34th Annual Meeting of International Society for the Study of the Lumbar Spine, Hong Kong, June 10-14, 2007. |
|
Researcher
: Leung HB |
|
List of Research Outputs |
|
Hu Y., Leung H.B., Lu W.W. and Luk K.D.K., Consequence of Paraspinal Muscle after Spinal Fusion: An experimental Study, Stud Health Technol Inform. 2006, 123: 461-466. |
|
Leung
H.B., Tseng H., Lu W.W., Cheung K.M.C. and Luk K.D.K., Pullout strength of screws
from bioactive bone cement versus polymethylmethacrylate bone cement, 26th
Annual Congress of the Hong Kong Orthopaedic Association, |
|
Researcher
: Leung KL |
|
List of Research Outputs |
|
Chan
C.F. and Leung K.L.,
Locking compression plate fixation of distal humeral fractures, The 26th
Hong Kong Orthopaedic Association Annual Congress, |
|
Lau T.W., Leung K.L., Chan C.F. and Chow S.P., Minimally invasive plate fixation of proximal humeral fractures, The 26th Hong Kong Orthopaedic Association Annual Congress, Hong Kong, 11-12 November 2006, . 2006. |
|
Leung K.L., Absolute stability, AO Basic Course for Surgeons, Makassar, Indonesia, 10-12 July 2006 . 2006. |
|
Leung
K.L., Approaches to the acetabulum, AO
Pelvic and Acetabular Course, |
|
Leung K.L., Gudushauri P., Fung B.K.K. and Chow S.P., Arthroscopic assessment of soft tissue injuries in comminuted intra-articular fractures of the distal radius, Chinese Journal of Orthopaedic Trauma. 2006, 8(3): 203-207. |
|
Leung
K.L., Associated DRUJ injuries in distal
radial fractures, AO Course in Upper Extremity Injuries, |
|
Leung
K.L., Bone healing, AO Principles Course
for Surgeons, |
|
Leung
K.L., Damgae control in musculoskeletal
injuries, |
|
Leung
K.L., Development of implants in fracture
surgery , The RCSEd/CSHK Conjoint Scientific Congress "Surgey: East
meets West", |
|
Leung K.L., Development of minimally invasive surgery, AO Basic Course for Surgeons, Makassar, Indonesia, 10-12 July 2006. |
|
Leung
K.L., Distal humeral fractures, AO
Principles |
|
Leung
K.L., Distal radial fracture, AO Seminar
in Fracture Management, |
|
Leung
K.L., Distal radial fractures, AO
Principles Course for Surgeons, |
|
Leung K.L., Distal radial fractures, The First International Congress of Chinese Orthopaedic Association, Beijing, PR China, 12-15 November 2006 . 2006. |
|
Leung
K.L., Distal tibial fractures |
|
Leung K.L., Distal tibial fractures, AO Basic Course for Surgeons, Makassar, Indonesia, 10-12 July 2006 . 2006. |
|
Leung
K.L., Elbow stiffness: case studies, AO
Course in Upper Extremity Injuries, |
|
Leung
K.L., Femoral neck fractures, AO Basic
Course for Surgeons, |
|
Leung
K.L., Femur, distal: extraarticular fracture,
simple 33 - A1, AO Manual of Fracture Management - Minimally invasive
plate osteosynthesis (MIPO). |
|
Leung
K.L., Forearm fractures, AO Basic Course
for Surgeons, |
|
Leung
K.L., Humeral shaft fracture: plating vs
intramedullary nailing, The 2nd International Summit Forum of Orthopaedic
Trauma (ISFOT), |
|
Leung
K.L., Humerus, proximal: extraarticular
unifocal fracture, non-impacted metaphyseal - 11-A3 with diaphyseal
involvement, AO Manual of Fracture Management - Minimally invasive plate
osteosynthesis (MIPO). |
|
Leung
K.L., Implants, AO Manual of Fracture
Management - Minimally invasive plate osteosynthesis (MIPO). |
|
Leung
K.L., Infection after fixation, AO
Principles |
|
Leung
K.L., Infection after fracture fixation, AO
Masters Course, |
|
Leung K.L. and Chow S.P., Locking compression plate in the treatment of forearm fractures: a prospective study, Journal of Orthopaedic Surgery. 2006, 14(3): 291-294. |
|
Leung
K.L., MIPO in fracture fixation, The First
International Congress of Chinese Orthopaedic Association, |
|
Leung
K.L., MIPO tibial shaft, AO Seminar in
Controversies of Modern Fracture Management, |
|
Leung
K.L., Minimally invasive surgery - Is it hip
or hype?, AO Seminar in Controversies of Modern Fracture Management, |
|
Leung K.L., Minimally invasive surgery in proximal humeral fractures, AO Seminar in Controversies of Modern Fracture Management. 2006. |
|
Leung
K.L., Pelvic fractures in children and
elderly, AOAA Symposium: Updates in Pelvic Fractures, |
|
Leung
K.L., Pitfalls in ankle fractures, AO
Seminar in Fracture Management, |
|
Leung
K.L., Pitfalls in hip fractures, AO
Seminar in Fracture Management, |
|
Leung
K.L., Plate fixation for distal radial
fractures, International Trauma Symposium: AO China-East Asia, |
|
Leung K.L., Plate fixation in distal radial fractures , The 6th Asian Pacific Federation of Societies for Surgery of the Hand, Bangkok, Thailand, 15-18 November 2006. |
|
Leung
K.L., Principles of fracture healing, AO
Principles |
|
Leung
K.L., Proximal humeral fractures |
|
Leung
K.L., Proximal humeral fractures, AO
Principles |
|
Leung
K.L. and Chow
S.P., Reduction techniques, AO Manual of Fracture Management -
Minimally invasive plate osteosynthesis (MIPO). |
|
Leung K.L., Relative stability - extramedullary technique, AO Basic Course for Surgeons, Makassar, Indonesia, 10-12 July 2006. |
|
Leung
K.L., The locked compression plate: biology,
biomechanics and clinical application, AO Principles Course for Surgeons, |
|
Leung
K.L., The locked plate: An overview of its
principle, 5th Annual Congress of the |
|
Leung K.L., Tibia and fibula, proximal: extraarticular fracture, metaphyseal, multifragmentary - 41- A3 with diaphyseal involvement, AO Manual of Fracture Management - Minimally invasive plate osteosynthesis (MIPO) . Swtizerland, Thieme, 2006, Chapter 16.3: 275-279. |
|
Lu W.W., Zhu L., Ni G., Leung K.L. and Chow S.P., Five fixation methods for unstable intra-articular fractures of the distal radius: an in vitro biomechanical study using cadaveric model, Chinese Journal of Orthopaedic Trauma. 2006, 8(3): 208-211. |
|
Yeung
Y. and Leung K.L., Mode of
failure of proximal femoral nail fixation in a Chinese population, The
First International Congress of Chinese Orthopaedic Association, |
|
Zhu Y. and Leung K.L., MIPO in distal tibial fractures, The First International Congress of Chinese Orthopaedic Association, Beijing, PR China, 12-15 November 2006 . 2006. |
|
Researcher
: Leung YL |
|
Project Title: |
Molecular identity of nucleus pulposus cells in intervertebral disc |
|
Investigator(s): |
Leung YL, Cheung KMC, Chan D |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
12/2005 |
|
Abstract: |
|
1) Introduction: Low back pain has been a
major focus in clinical practice. It represents a world-wide health problem
of which about 70-80% population will experience low back pain in their
lifetime [1,6]. Intervertebral disc degeneration has been suggested to
associate with low back pain and sciatica and is thought to have
multi-factorial causes. Previous study in human indicated that 90% of people
will develop intervertebral disc degeneration above the age of 50. However,
whether the degeneration is caused by natural aging or other unknown
pathological conditions is still not clear [2]. Intervertebral discs (IVD)
are avascular fibrocartilagenous structures between the vertebral bodies of
the spine which function to articulate the spinal motion and are subject to
high mechanical loading. Degeneration of IVD is generally characterized by
changes in disc morphology, composition of extracellular matrix (ECM), loss
of proteoglycan and water content, and an up-regulation of metalloproteinases
in IVD [2,8-10]. Nonetheless, there is a lack of consensus on the cause of
degeneration. In particular, whether the degeneration is a result from a loss
of mechanical integrity in the disc or the mechanical loading itself being a
precipitating factor of the degeneration is still controversial [6,7].
Studies have also suggested that the degeneration is related to a change of
disc cells response to mechanical stimuli [11], but the molecular events
happened during the response have not been clearly elaborated. IVD consists
of three components: an outer fibrous ring (annulus fibrosus, AF), an inner
gelatinous filling (nucleus pulposus, NP), and cartilaginous endplates (EP)
which sandwich the former two structures. During organogenesis, NP is
developed from the transformation of notochord and AF is differentiated from
the condensation of sclerotome, implying that IVD is derived from mesodermal
origin [3,4]. IVD is populated by three major cell types: chondrocytes in EP,
notochordal/chondrocyte-like cells in NP and fibroblast-like cells in AF. NP
and AF contain abundant ECM, particularly collagens and proteoglycans, which
are present in different proportions in the two structures [6]. Cells in IVD
have been defined base on their morphology, intercellular organization, and
gene expression. NP is composed of a heterogeneous cell population of
interconnected cells with prominent vacuoles, which are thought to be
originated from the notochord, and small chondrocyte-like cells from yet
unknown origin [12]. The notochordal cells appear to be replaced with
chondrocyte-like cells during IVD maturation. The replacement of cells may be
possibly due to apoptosis of notochordal cells together with an invasion of
chondrocytes from AF or EP, or due to differentiation of notochordal cells
into chondrocytic phenotype. Study has demonstrated that degeneration is not
observed in IVD where notochordal cells persist to adult age, suggesting
notochordal cells play vital role in maintaining IVD integrity [21]. Among
various species studied, mature sheeps, dogs, and rats are suggested to
retain NP cell populations mimicking those in adult humans [12]. In situ
expression of variety of genes has been studies in NP. They express
chondrocyte markers such as SOX9, collagen II and IX, agreccan, decorin,
TGFbeta, and Ptc [13-18]. Gene knockout in mice has demonstrated that Sox5
and Sox6 regulate NP formation while Col |
|
List of Research Outputs |
|
Cheung K.M.C. and Leung Y.L., Rebuilding the degenerated intervertebral discs by bone marrow stem cells, The Hong Kong Medical Diary. 2007, 12: 28. |
|
Leung Y.L., Wu E.X., Luk K.D.K., Chan D. and Cheung K.M.C., Allogeneic mesenchymal stem cell transplantation into the intervertebral disc: effect of severity of degeneration and cell number on regeneration, The Annual Meeting of the International Society for the Study of the Lumbar Spine. 2007. |
|
Leung Y.L., Wu E.X., Luk K.D.K., Chan D. and Cheung K.M.C., Regeneration of degenerated intervertebral disc using allogeneic Mesenchymal stem cells encapsulated in self-assembling peptide hydrogel, 53rd Annual Meeting of the Orthopaedic Research Society. 2007. |
|
Yang
F., Cheung K.M.C., Lu W.W., Leung Y.L., Chan D. and Luk K.D.K., A Simple Annular Puncture
Model Of Disc Degeneration In The Mouse Tail, International Society for
the Study of the Lumbar Spine. 34th Annual Meeting. |
|
Researcher
: Li Z |
|
List of Research Outputs |
|
Abbah S.A., Lu W.W., Chan D., Cheung K.M.C., Liu W., Zhao F., Li Z., Leong J.C.Y. and Luk K.D.K., In vitro evaluation of alginate encapsulated adipose-tissue stromal cells for use as injectable bone graft substitute., Biochem Biophys Res Commun. 2006, 347(1): 185-91. |
|
Li Z., Lam R.W.M., Yang C., Xu B., Ni G., Abbah S.A., Cheung K.M.C., Luk K.D.K. and Lu W.W., Chemical composition, crystal size and lattice structural changes after incorporation of strontium into biomimetic apatite, Biomaterials. 2007, 28(7): 1452-60. |
|
Ni G., Lu W.W., XU B., Chiu P.K.Y., Yang C., Li Z., Lam R.W.M. and Luk K.D.K., Interfacial behaviour of strontium-containing hydroxyapatite cement with cancellous and cortical bone, Biomaterials. 2006, 27: 5127-5133. |
|
Ni G., Chiu P.K.Y., Lu W.W., Wang Y., Zhang Y.G., Hao L., Li Z., Lam R.W.M. and Luk K.D.K., Strontium-containing hydroxyapatite bioactive bone cement in revision hip arthroplasty, Biomaterials. 2006, 27: 4348-4355. |
|
Researcher
: Liu H |
|
List of Research Outputs |
|
Hu Y.,
Mak J.N.F., Liu H. and Luk K.D.K., ECG Cancellation for Surface
Electromyography Measurement Using Independent Component Analysis, 2007
IEEE International Symposium on Circuits and Systems Proceedings. 2007, May. |
|
Researcher
: Liu W |
|
List of Research Outputs |
|
Abbah S.A., Lu W.W., Chan D., Cheung K.M.C., Liu W., Zhao F., Li Z., Leong J.C.Y. and Luk K.D.K., In vitro evaluation of alginate encapsulated adipose-tissue stromal cells for use as injectable bone graft substitute., Biochem Biophys Res Commun. 2006, 347(1): 185-91. |
|
Researcher
: Lu D |
|
List of Research Outputs |
|
Luk K.D.K. and Lu D., 兒童脊柱結核的後凸畸形, In: 吳啟秋及林羽 主編,, 骨關節結核 (Tuberculosis of Bone and Joint. PR China, 人民衛生出版社, 2006, 1: 197-206. |
|
Poon A.M.S., Cheung K.M.C., Lu D. and Leong J.C.Y., Changes in melatonin receptors in relation to the development of scoliosis in pinealectomized chickens, Spine. Lippincott Williams & Wilkins, Inc, 2006, 31: 2043-2047. |
|
Researcher
: Lu W |
|
List of Research Outputs |
|
Chan B.P., Hui T.Y., Chan C.M., So K.F., Lu W., Cheung K.M.C., Salomatina E. and Yaroslavsky A., Photochemical cross-linking for collagen-based scaffolds: a study on optical properties, mechanical properties, stability, and hematocompatibility, Tissue Engineering. 2007, 13(1): 73-85. |
|
Chan
C.W., Gantenbein B., Chan D., Lu W., Cheung K.M.C., Lezuo P. and Ito K., Fate
of Mesenchymal Stem Cells Injected Into Intervertebral Discs, International
Society for the Study of the Lumbar Spine. 34th Annual Meeting. |
|
Researcher
: Lu WW |
|
Project Title: |
Use of a new bioactive bone cement in the treatment of osteoporotic spinal fracture |
|
Investigator(s): |
Lu WW, Fong DYT, Cheung KMC, Ni G, Luk KDK |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
S.K. Yee Medical Foundation - General Award |
|
Start Date: |
10/2004 |
|
Abstract: |
|
To help the poor and sick who suffer from
osteoporotic spinal fractures; to apply for the market permit both in Hong
Kong and |
|
Project Title: |
Novel Strontium Hydroxyapatite Nanowhisker (Sr-HA-Nano) reinforced bioactive cement for bone fracture treatment |
|
Investigator(s): |
Lu WW, Chan WK, Xu B, Ngan AHW, Luk KDK |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Innovation and Technology Support Programme |
|
Start Date: |
09/2006 |
|
Abstract: |
|
(1) To develop a novel strontium-hydroxyapatite nanowhisker (Sr-HA-Nano) reinforced bioactive bone cement. (2) To provide a complete mechanical and biocompatible profile of novel Sr-HA nanowhisker cement follow ISO 5883 and ISO 10993 standards. The key issue of this study is to improve bending and fatigue strength of the current Sr-HA bioactive bone cement. Based on literature review, the weak filler fracture toughness, the microvoid formation during mixing, and the filler aggregations are the major cause of lower mechanical strength. One solution to solve these problems is to reinforce the cement with the stronitum hydroxyapatite nanowhisker and by surface treatment using acrylolpamidonate. To further increase the mechanical strength of the novel bioactive boen cement, we will apply surface treatment to the inorganic fillers using acrylolpamidonate which will increases filler surface hydrophobicity assisting dispersion within non-polar resin phase. |
|
Project Title: |
Pullout strength of screws from bioactive bone cement vs Polymethylmethacrylate bone cement |
|
Investigator(s): |
Lu WW, Luk KDK, Cheung KMC |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
12/2006 |
|
Abstract: |
|
The purpose of this study is to examine
and compare the pullout strengths of pedicle screws from bioactive
strontium-containing hydroxyapatite bone cement (Sr-HA) and
polymethylmethacrylate bone cement (PMMA) in different insertion timings. The
pedicle screw is a component of spinal implants commonly used in spinal
fusion for various diseases such as scoliosis, infection and tumour. In
patients suffering from osteoporosis or a tumour, the bone quality of their
vertebrae would be weakened and render the fixation of a pedicle screw
unsecured. A surgeon might utilise bone cement, classically PMMA, to augment
the screw purchase. PMMA is not a glue, rather, is an inert void filler. It
cannot encourage bone ingrowth and might even fail with time due to
mechanical fatigue. On the contrary, the bioactive Strontium-Hydroxapatite
bone cement, which was developed, patented and commercialised by the
Department of Orthopaedics and Traumatology at Hong Kong University, might
surpass the traditional PMMA by the virtue of its unique ability to promote
bone ingrowth. Even for the classical PMMA bone cement, there have been only
a few articles concering the pullout strength of screws. Flahiff et al
discovered that the pullout strength was highest for screws inserted into
doughy cement and lowest for screws inserted into hard cement. Apart from the
strength, the modes of failure were also different. It was postulated that
the timing of screw insertion cast an effect on interdigitation and hence the
strength in screw-cement and bone-cement interfaces. However, as the
experiment carried a lot of variables, conclusion of the best timing could
hardly be arrived at. To simplify the model, Motzkin et al utilised cement
blocks for mechanical test. They found a significantly stronger pullout strength
for screws placed in fluid and solid polymethylmethacrylate (PMMA). Critics
arose as they only tested cement blocks with a thickness of |
|
Project Title: |
The micro-structure and micro-mechanics of human intervertebral disc |
|
Investigator(s): |
Lu WW, Ngan AHW, Cheung KMC, Luk KDK |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
12/2006 |
|
Abstract: |
|
(1) Purpose: This study aims to apply state-of-the-art techniques to study the micro and nano mechanical properties of both normal human intervertebral discs and discs at different grades of degeneration, producing a database available for future reference. (2) Objectives: (a) Testing the mechanics of a bundle of collagen fibrils from Annulus Fibrosus of human intervertebral discs; and (b) Mechanically testing the individual collagen fibrils at nano-level by stretching the fibrils in force spectroscopy mode (contact mode) of the Atomic Force Microscope (AFM). (3) Key issues: Low back pain (LBP) is a common and significant problem worldwide. Compensation for occupation related injuries and LBP in Hong Kong alone amounts to about HK$675 million a year. A recent survey suggested Hong Kong is one of the most LBP-afflicted communities in the world, with a cumulative life prevalence of 57% for all age groups, and peaks at ages 45 to 54 with a life prevalence of 68%13. (4) Degenerative disc disease (DDD) is one of the most common causes of LBP and sciatica. Current methods of treatment do not address the underlying problem of degenerated and non-functional discs, but rather by-pass it by spinal fusion. Recently, there has been substantial interest in developing artificial discs by tissue engineering, but none have so far shown any significant clinical outcome. This is because the pathophysiology, micro biomechanics and molecular mechanisms of disc degeneration are poorly understood. (5) As the ‘building blocks’ of disc tissue, collagens play a vital role in the functional integrity of discs. It has been proposed4 that the collagen’s structural disturbance and cross-linking destruction contribute significantly towards DDD. But there is no data on collagen levels comparing normal and abnormal mechanical properties. Since the problem is at molecular level, we plan to conduct mechanical testing at micro and molecular levels. (6)Long term impact: This study will quantify the mechanical properties of human disc collagens from both normal discs and discs at different grades of degeneration. The new information should provide guidelines for developing and evaluating new tissue engineering techniques to treat and reconstruct degenerated discs. DDD is related to the mechanical functionality of discs, which research has yet to fully resolve. (7)Hopefully, our study will contribute significantly towards understanding the mechanical properties of disc collagens and their influence on the initiation and progression of DDD. This knowledge will influence future research and eventually contribute towards new treatment strategies such as gene therapy and tissue engineered intervertebral disc replacements. Ultimately, our study will benefit all patients suffering from low back pain, and reduce the cost to society as a whole through reduced compensation payments, sick leave, lost workdays and hospital treatment costs. |
|
Project Title: |
Optimization and commercialization of strontium containing bioactive bone cement for various orthopaedic applications |
|
Investigator(s): |
Lu WW, Chan WK, Xu B, Chiu PKY, Luk KDK, Ngan AHW |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Guangdong-Hong Kong Technology Cooperation Funding Scheme |
|
Start Date: |
04/2007 |
|
Abstract: |
|
(1) Optimize and commercialize three new brands of Sr-HA bone cement to fulfill the application in three major areas: (i) Osteoporotic spinal fracture (Sr-HA Spine), (ii) Total hip replacement implant augmentation (Sr-HA Hip) and (iii) Bone tumor, or bone cavity filler (Sr-HA Filler). (2) Provide a complete mechancial and biocompatibility profile of the modified Sr-HA cement formulation as per the ISO 5883 and ISO 10993 standards. (3) Carry out 30-35 cases of clinical trials on bioactive bone cement as a total hip replacement fixation agent. (4) Filing the standards for application to local or international medical device licensing organizations for marketing. The key issue of this study is to optimize present Sr-HA bioactive bone cement by modifying its composition to fulfill a wied variety of orthopaedic application requirements while preserving its desired properties of bioactivity and osteointegration. Ultimately, we aim at replacing the current non-bioactive PMMA bone cement with bioactive bone cements suitable for the particular needs which can significantly reduce clincial complications and improve the quality of life among the patients. |
|
List of Research Outputs |
|
Abbah S.A., Lu W.W., Chan D., Cheung K.M.C., Liu W., Zhao F., Li Z., Leong J.C.Y. and Luk K.D.K., In vitro evaluation of alginate encapsulated adipose-tissue stromal cells for use as injectable bone graft substitute., Biochem Biophys Res Commun. 2006, 347(1): 185-91. |
|
Aladin K.D.M., Lu W.W., Cheung K.M.C., Ngan A.H.W., Chan D. and Luk K.D.K., " Nano Biomechanics Of Type Ii Collagens In Human Intervertebral Discs", Best Paper Award; Conference on Biomedical Engineering, BME 2006. Hong Kong. 2006. |
|
Aladin
Kaderbatcha D.M., Lu W.W.,
Chan D., Yee A.F.Y., Jim J.J.T., Luk K.D.K. and Cheung K.M.C., EXPRESSION OF THE TRP2
ALLELE OF COL |
|
Aladin Kaderbatcha D.M., Lu W.W., Cheung K.M.C., Ngan A.H.W., Chan D. and Luk K.D.K., Nano Structure and Biomechanics of Human Intervertebral Disc Collagens, International Society for the Study of the Lumbar Spine. 34th annual Meeting, June 10-14,Hong Kong . 2007. |
|
Chan
Y.L., Yeung K.W.K., Ngan A.H.W., Cheung K.M.C., Lu W.W., Luk K.D.K., Liu X.M. and |
|
Chan
Y.L., Yeung K.W.K., Lu W.W., Ngan A.H.W., Luk K.D.K., Chan D., Wu S.L., Liu X.M., |
|
Cheung K.M.C., Yeung K.W.K., Chung J.C.Y. and Lu W.W., Shape memory material and method of making the same, Japan Non-Provisional Patent No. 2006-523770 filed October 19, 2006. 2006. |
|
Ho J.P.Y., Wu S.L., Poon R.W.Y., Chung
C.Y., Tjong S.C., |
|
Hu Y., Leung H.B., Lu W.W. and Luk K.D.K., Consequence of Paraspinal Muscle after Spinal Fusion: An experimental Study, Stud Health Technol Inform. 2006, 123: 461-466. |
|
Hu Y., Mak J.N.F., Lu W.W. and Luk K.D.K., Surface Electrography Topography As An Assessment for Low Back Pain Rehabilitation, The 3rd International IEEE EMBS Conference on Neural Engineeering. Kohala Coast, Hawaii, USA (2-5 May 2007). 2007, 557-60. |
|
Lam R.W.M., Cheung K.M.C., Lu W.W., Luk K.D.K. and Wong C.T., Bone Composition and Crystal Structure after Strontium Treatment for Osteoporosis Goat Model. , Young Investigator Award, 8th Regional Osteoporosis Conference, The Osteoporosis Society of Hong Kong. . 2007. |
|
Leung H.B., Tseng H., Lu W.W., Cheung K.M.C. and Luk K.D.K., Pullout strength of screws from bioactive bone cement versus polymethylmethacrylate bone cement, 26th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 11-12, 2006. |
|
Li Z., Lam R.W.M., Yang C., Xu B., Ni G., Abbah S.A., Cheung K.M.C., Luk K.D.K. and Lu W.W., Chemical composition, crystal size and lattice structural changes after incorporation of strontium into biomimetic apatite, Biomaterials. 2007, 28(7): 1452-60. |
|
Liu X., Wu S., Chan Y.L., |
|
Liu X.M., Wu S.L., |
|
Liu X.M., Wu S.L., |
|
Lu W.W., Zhu L., Ni G., Leung K.L. and Chow S.P., Five fixation methods for unstable intra-articular fractures of the distal radius: an in vitro biomechanical study using cadaveric model, Chinese Journal of Orthopaedic Trauma. 2006, 8(3): 208-211. |
|
Ni G., Lu W.W., XU B., Chiu P.K.Y., Yang C., Li Z., Lam R.W.M. and Luk K.D.K., Interfacial behaviour of strontium-containing hydroxyapatite cement with cancellous and cortical bone, Biomaterials. 2006, 27: 5127-5133. |
|
Ni G., Lu W.W., Ngan A.H.W. and Luk K.D.K., Nanomechanics of bone and bioactive bone-cement interfaces, In: Ling Qin, Harry K. Genant, James Griffith, Kwok-Sui Leung, Advanced Bioimaging Technologies in Assessment of the Quality of Bone and Scaffold Materials Techniques and Applications. Springer, 2007, 613-625. |
|
Ni G., Chiu P.K.Y., Lu W.W., Wang Y., Zhang Y.G., Hao L., Li Z., Lam R.W.M. and Luk K.D.K., Strontium-containing hydroxyapatite bioactive bone cement in revision hip arthroplasty, Biomaterials. 2006, 27: 4348-4355. |
|
Ning C., Wang Y., Lu W.W., Qiu Q.X., Lam R.W.M., Chen X.F., Chiu P.K.Y., Ye J.D., Wu G., Wu Z.H. and Chow S.P., Nano-structural bioactive gradient coating fabricated by computer controlled plasma-spraying technology , Journal of Materials Science. Materials in Medicine. 2006, 17(10): 875-884. |
|
Tang B., Ngan A.H.W. and Lu W.W., A novel method to measure the mechanical properties of bio-tissues using nanoindentation, Proceedings of University of Tokyo (UT) Symposium on Nanobio Integration NANOBIO-TOKYO 2006. 145-148. |
|
Tang B., Ngan A.H.W. and Lu W.W., An improved method for the measurement of mechanical properties of bone by nanoindentation, Journal of Materials Science: Materials in Medicine. Springer, 2007, 18: 1875-1881. |
|
Tang B., Ngan A.H.W. and Lu W.W., Nanoindentation size effects of cortical bone, Proceedings of University of Tokyo (UT) Symposium on Nanobo Integration NANOBIO-TOKYO 2006. 149-150. |
|
Tang B., Ngan A.H.W. and Lu W.W., Viscoelastic effects during depth-sensing indentation of cortical bone tissues, Philosophical Magazine. Taylor & Francis, 2006, 86(33-35): 5653-5666. |
|
Tong H.W., Wang M., Lu W.W., Cheung K.M.C., Yeung K.W.K. and Luk K.D.K., Pedicle screws and rods made of a shape memory alloy for treating scoliotic patients, Proceedings of the Biomedical Engineering Conference BME2006. Hong Kong, HKIE, 127-130. |
|
Wong K.W.N., Luk K.D.K., Leong J.C.Y. and Lu W.W., Lumbar segmental motion patterns in patients with degenerative spondylolisthesis were detected with digital videofluoroscopic videos and distortion compensated Roentgen Analysis System, 34th Annual Meeting of International Society for the Study of the Lumbar Spine, Hong Kong, June 10-14, 2007. |
|
Wu S.L., Chung C.Y., Liu X.M., |
|
Yang F., Cheung K.M.C., Lu W.W., Leung Y.L., Chan D. and Luk K.D.K., A Simple Annular Puncture Model Of Disc Degeneration In The Mouse Tail, International Society for the Study of the Lumbar Spine. 34th Annual Meeting. Hong Kong June 10-14 . 2007. |
|
Yang F., Chan D., Leong V.Y.L., Lu W.W., Luk K.D.K. and Cheung K.M.C., A Simple Novel Annular Puncture Model of Disc Degeneration in the Mouse Tail., 11th Research Postgraduate Symposium, 7 Dec. 2006. The University of Hong Kong, Li Ka Shing Faculty of Medicine. 2006. |
|
Yeung K.W.K., Lu W.W., Luk K.D.K. and Cheung K.M.C., A novel "smart" spinal impact locking mechanism based on nickel-titanium alloy., Spine. 2006, 31(20): 2296-2303. |
|
Yeung
K.W.K., Chan Y.L., Lam K.O., Liu X.Y., Chung C.Y., |
|
Yeung
K.W.K., Poon R.W.Y., Chung C.Y., Liu X.Y., |
|
Yeung
K.W.K., Wu S.L., Liu X.M., Chung C.Y., |
|
Yeung
K.W.K., Lam K.O., Chan Y.L., Wu S.L., Liu X.Y., Chung
C.Y., |
|
Yeung
K.W.K., Chan Y.L., Lam K.O., Liu X.Y., Chung C.Y., |
|
Researcher
: Luk KDK |
|
Project Title: |
A minimal invasive approach to anterior release in scoliosis by chemonucleolysis: an experimental study with the rabbit scoliosis model |
|
Investigator(s): |
Luk KDK |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Outstanding RGC Projects |
|
Start Date: |
09/1998 |
|
Abstract: |
|
To investigate whether the effect of chymopapain on generating spinal lateral instability can be used to treat scoliosis deformity; to develop a thoracoscopic-assisted or CT-guided chemonucleolysis technique to replace the conventional anterior spinal release method. |
|
Project Title: |
Provision of individualized biomechanical and electrophysiological service for occupational low back disorder patients |
|
Investigator(s): |
Luk KDK, Lu WW, Hu Y |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
S.K. Yee Medical Foundation - General Award |
|
Start Date: |
12/2003 |
|
Abstract: |
|
To assess the low back muscular function and biomechanical problems of low back disorder patients to identify, evaluate and quantify potential of factors of OLBD; to study the drawbacks and benefits of conventional treatments; to introduce an individualized biomechanical and electrophysiological assessment service to identify specific OLBD problems in individual patients, and provide guidelines both for an optimal rehabilitation treatment and for a future workplace regimen to prevent recurrence. |
|
Project Title: |
Investigation on in-vivo Mechanical Properties of Degenerated Intervertebral Disc Using Magnetic Resonance Elastography |
|
Investigator(s): |
Luk KDK |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
03/2005 |
|
Abstract: |
|
Intervertebral disc degeneration is frequently cited as a cause of low back pain as it would lead to changes in mechanical properties of the disc, causing instability of the spine. In most of the cases, “black disc” and “high intensity zone” in MRI are diagnostic signs of disc degeneration but there is no definite evidence that this is the gold standard for diagnosis of low back pain. With the development of the MRI techniques, Magnetic Resonance Elastography (MRE), it allows in-vivo measurement of the mechanical properties of different tissues. MRE is a phase-contrast-based technique that can directly visualize and quantitatively measure local values of shear modulus, elasticity and stiffness by propagating acoustic strain waves in tissue subjected to harmonic mechanical excitation[1, 2]. Since the discovery of MRE, studies have been performed in animal tissue[3, 4], human brain[5] and human skeletal muscle[6] to find the mechanical properties of different tissues. MRE has also been shown to be an effective diagnostic tool for breast cancer[7, 8]. However, this technique has not been developed in the intervertebral disc and its application on diagnosis of disc diseases has not yet been explored either. In the current study, we will apply MRE to disc. Objective This study will apply MRE to detect the mechanical property of spinal disc in normal subjects and patients with degenerative disc disease. Mechanical property change due to pathological condition will be characterized. References [1] R. Muthupillai, P. J. Rossman, D. J. Lomas, J. F. Greenleaf, S. J. Riederer & R. L. Ehman, Magnetic resonance imaging of transverse acoustic strain waves, Magn Reson Med 36(2), 1996, 266-274. [2] R. Muthupillai, D. J. Lomas, P. J. Rossman, J. F. Greenleaf, A. Manduca & R. L. Ehman, Magnetic resonance elastography by direct visualization of propagating acoustic strain waves, Science 269(5232), 1995, 1854-1857. [3] S. A. Kruse, J. A. Smith, A. J. Lawrence, M. A. Dresner, A. Manduca, J. F. Greenleaf & R. L. Ehman, Tissue characterization using magnetic resonance elastography: preliminary results, Phys. Med. Biol. 45, 2000, 1579-1590. [4] J. Bishop, G. Poole, M. Leitch & D. B. Plewes, Magnetic resonance imaging of shear wave propagation in excised tissue, J Magn Reson Imaging 8(6), 1998, 1257-1265. [5] S. A. Kruse, M. A. Dresner, P. J. Rossman, J. P. Felmlee, C. R. Jack & R. L. Ehman, 'Palpation of the brain' using magnetic resonance Ultraelastography. 7thISMRM, 1999, 258. [6] M. A. Dresner, G. H. Rose, P. J. Rossman, J. A. Smith, R. Muthupillai & R. L. Ehman, Functional MR elastography of human skeletal muscle. 6thISMRM, 1998, 463. [7] A. J. Lawrence, P. J. Rossman, J. L. Mahowald, A. Manduca, L. C. Hartmann & R. L. Ehman, Assessment of breast cancer by magneticresonance elastography. 7thISMRM, 1999, 525. [8] R. Sinkus, J. Lorenzen, D. Schrader, M. Lorenzen, M. Dargatz & D. Holz, High-resolution tensor MR elastography for breast tumour detection, Phys Med Biol 45(6), 2000, 1649-1664. |
|
Project Title: |
Proposal to develop the strategic research area on biomedical engineering |
|
Investigator(s): |
Luk KDK, Man RYK, Che CM, Cheung LK, Cheung PYS, Lu WW |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Seed Funding for Strategic Research Theme |
|
Start Date: |
05/2005 |
|
Abstract: |
|
To improve quality of life through pioneering scientific discoveries and the education of future leaders in the medical and biotehnology fields. To establish an intra-institutional Biomedical Engineering research area with three sub-themes: Biomaterials and Tissue engineering; Electro-physioloyg/signal processing; Imaging/MRI. To foster interdisciplinary biomedical engineering by setting up a BME research core facility platform and to jointly secure external research grants. Establish joint appointments or ADjunct Professorship between Faculties of Dentistry, Engineering, Medicine, and Science. Recruitment RAP, PDF and RPG in these areas. Plan a unique integration between academia, clinical medicine and industry which enable biotechnology transfer. |
|
Project Title: |
Spinal perfusion imaging in cervical myelopathy patients |
|
Investigator(s): |
Luk KDK, Yang ES, Hu Y, Wu EX |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
03/2006 |
|
Abstract: |
|
The objective of this project is to apply perfusion imaging (PI), a magnetic resonance dynamic imaging technique, to investigate the haemoglobin status of the cervical spinal cord, which may reveal the mechanism of surgical treatment on cervical spondylotic myelopathy (CSM). CSM is the most common spinal cord disorder affecting the elderly, and its incidence has increased significantly in recent years with the aging trend in the population in Hong Kong. Currently, the problem faced is that the mechanism of surgical treatment on CSM is not fully understood. The lack of understanding of the pathophysiology of CSM limits the rationale for improved treatment strategies. As well, the limit pathophysiology understanding also creates difficulties in the accurate and precise diagnosis of neurological functional deficits. The key issue here is to obtain a detailed understanding of the compression-associated pathomechanism of CSM and the changes after different surgical treatments. In this study, perfusion imaging will be applied to investigate the haemoglobin status of the cervical spinal cord and the relevant changes regarding different surgical treatments. |
|
List of Research Outputs |
|
Abbah S.A., Lu W.W., Chan D., Cheung K.M.C., Liu W., Zhao F., Li Z., Leong J.C.Y. and Luk K.D.K., In vitro evaluation of alginate encapsulated adipose-tissue stromal cells for use as injectable bone graft substitute., Biochem Biophys Res Commun. 2006, 347(1): 185-91. |
|
Aladin K.D.M., Lu W.W., Cheung K.M.C., Ngan A.H.W., Chan D. and Luk K.D.K., " Nano Biomechanics Of Type Ii Collagens In Human Intervertebral Discs", Best Paper Award; Conference on Biomedical Engineering, BME 2006. Hong Kong. 2006. |
|
Aladin
Kaderbatcha D.M., Lu W.W., Chan D., Yee A.F.Y., Jim J.J.T., Luk K.D.K. and Cheung K.M.C., EXPRESSION OF THE TRP2
ALLELE OF COL |
|
Aladin Kaderbatcha D.M., Lu W.W., Cheung K.M.C., Ngan A.H.W., Chan D. and Luk K.D.K., Nano Structure and Biomechanics of Human Intervertebral Disc Collagens, International Society for the Study of the Lumbar Spine. 34th annual Meeting, June 10-14,Hong Kong . 2007. |
|
Bullmann V., Cheung K.M.C., Halm H.H.F., Senkoylu A., Luk K.D.K. and Liljenqvist U.R., Comparative sagittal plane correction after anterior single rod versus dual rod instrumentation in idiopathic thoracolumbar and lumbar scoliosis, EuroSpine 2006, Istanbul, Turkey, October 25-28, 2006. |
|
Chan
Y.L., Yeung K.W.K., Ngan A.H.W., Cheung K.M.C., Lu W.W., Luk K.D.K., Liu X.M. and |
|
Chan
Y.L., Yeung K.W.K., Lu W.W., Ngan A.H.W., Luk K.D.K., Chan D., Wu S.L., Liu X.M., |
|
Cheung K.M.C., Chan D., Karppinen J., Chen Y.Q., Jim J.J.T., Yip S.P., Ott J., Wong K.K., Sham P.C., Luk K.D.K., Cheah K.S.E., Leong J.C.Y. and Song Y., Association of the Taq I allele in vitamin D receptor with degenerative disc disease and disc bulge in a Chinese population, Spine. 2006, 31(10): 1143-1148. |
|
Cheung K.M.C., Fan B., Karppinen J., Leong J.C.Y. and Luk K.D.K., Can age-related interverterbal disc changes be differentiated from degenerative disc disease?, 34th Annual Meeting of International Society for the Study of the Lumbar Spine, Hong Kong, June 10-14, 2007. |
|
Cheung K.M.C., Bullmann V., Senkoylu A., Halm H.F.H., Wong Y.W., Luk K.D.K. and Liljenqvist U.R., Comparative sagittal plane correction after anterior single rod versus dual rod instrumentation in idiopathic thoracolumbar and lumbar scoliosis, 41st Annual Meeting of the Scoliosis Research Society, Monterey, California, September 13-16, 2006. |
|
Cheung K.M.C., Luk K.D.K., Ho D.W.H., Chan D., Cheah K.S.E. and Song Y., Linkage analysis on familial early-onset degenerative disc disease. , Best Poster Award. 34th Annual Meeting of International Society for the Study of the Lumbar Spine, Hong Kong. 2007. |
|
Cheung K.M.C., Karppinen J., Guo G.G., Fan B., Leong J.C.Y. and Luk K.D.K., Relationship Between MRI Changes of The Lumbar Spine and Low Back Pain: A MRI Study of 1043 Population-Based Subjects., International Society for the Study of the Lumbar Spine. 34th Annual Meeting. Hong Kong June 10-14. 2007. |
|
Cheung K.M.C., Karppinen J., Guo G.G., Fan B., Leong J.C.Y. and Luk K.D.K., Relationship between MRI changes of the lumbar spine and low back pain: a MRI study of 1043 population-based subjects, 34th Annual Meeting of International Society for the Study of the Lumbar Spine, Hong Kong, June 10-14, 2007. |
|
Cheung K.M.C., Cheng A.C.S., Cheung W.Y., Chooi Y.S., Wong Y.W. and Luk K.D.K., Right hip adduction deficit is prevalent in patients with adolescent idiopathic scoliosis, 26th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 11-12, 2006. |
|
Cheung K.M.C., Song Y., Kao P.Y.P., Ho D.W.H., Fan B., Karppinen J., Yip S.P., Cheong J.C.Y., Luk K.D.K., Ott J., Cheah K.S.E., Sham P.C. and Chan D., Three genes in the aggrecan degradation pathway act synergistically to predispose to degenerative disc disease., International Society for the Study of the Lumbar Spine. 34th annual Meeting, June 10-14, 2007 Hong Kong. 2007. |
|
Cheung K.M.C., Song Y., Kao P.Y.P., Ho D.W.H., Fan B., Karppinen J., Yip S.P., Leong J.C.Y., Luk K.D.K., Ott J., Cheah K.S.E., Sham P.C. and Chan D., Three genes in the aggrecan degraduation pathway act synergistically to predispose to degenerative disc disease, 34th Annual Meeting of International Society for the Study of the Lumbar Spine, Hong Kong, June 10-14, 2007. |
|
Cheung W.Y., Wong Y., Cheung K.M.C., Wong Y.W. and Luk K.D.K., Fulcrum bending correct rotational deformity in adolescent idiopathic scoliosis, 26th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 11-12, 2006. |
|
Choi M.Y., Chan C.C.Y., Chan D., Luk K.D.K., Cheah K.S.E. and Tanner J.A., Molecular Mechanism of Disease for Spondyloepiphyseal Dysplasia Tarda-Effect of Mutations on sedlin structure and Function., 11th Research Postgraduate Symposium, 7 Dec. 2006. The University of Hong Kong, Li Ka Shing Faculty of Medicine. 2006. |
|
Ho D.W.H., Cheung K.M.C., Chan D., Karppinen J., Yip S.P., Ott J., Luk K.D.K., Leong J.C.Y., Cheah K.S.E., Sham P.C. and Song Y., Linkage Analysis on Familial Early-Onset Degenerative Disc Disease (DDD)., ABS#apbc056 Jan14-17. 2007. |
|
Ho D.W.H., Cheung K.M.C., Chan D., Karppinen J., Yip S.P., Ott J., Luk K.D.K., Leong J.C.Y., Cheah K.S.E., Sham P.C. and Song Y., Linkage analysis on familial early onset degenerative disc disease, 34th Annual Meeting of International Society for the Study of the Lumbar Spine, Hong Kong, June 10-14, 2007. |
|
Ho J.P.Y., Wu S.L., Poon R.W.Y., Chung C.Y.,
Tjong S.C., |
|
Hu Y., Leung H.B., Lu W.W. and Luk K.D.K., Consequence of Paraspinal Muscle after Spinal Fusion: An experimental Study, Stud Health Technol Inform. 2006, 123: 461-466. |
|
Hu Y., Mak J.N.F., Liu H. and Luk K.D.K., ECG Cancellation for Surface Electromyography Measurement Using Independent Component Analysis, 2007 IEEE International Symposium on Circuits and Systems Proceedings. 2007, May. New Orleans. 2007, 3235-8. |
|
Hu Y., Mak J.N.F., Lu W.W. and Luk K.D.K., Surface Electrography Topography As An Assessment for Low Back Pain Rehabilitation, The 3rd International IEEE EMBS Conference on Neural Engineeering. Kohala Coast, Hawaii, USA (2-5 May 2007). 2007, 557-60. |
|
Lam R.W.M., Cheung K.M.C., Lu W.W., Luk K.D.K. and Wong C.T., Bone Composition and Crystal Structure after Strontium Treatment for Osteoporosis Goat Model. , Young Investigator Award, 8th Regional Osteoporosis Conference, The Osteoporosis Society of Hong Kong. . 2007. |
|
Lau H.L., Ng M.Y.M., Cheung W.M.W., Paterson A.D., Luk K.D.K., Chan V.N.Y. and Kung A.W.C., Assessment of linkage and association of 13 genetic loci with bone mineral density, J Bone Miner Metab. 2006, 24: 226-34. |
|
Leong V.Y.L., Hung S.C., Tsui Y.K., Lee M.K., Li L.C., Lo G.G., Masuda K., Wu E.X., Luk K.D.K., Chan D. and Cheung K.M.C., Allogenic Mesenchymal Stem Cell Transplantation Into The Intervertebral Disc: Effect Of Severity Of Degeneration And Cell Number On Regeneration , International Society for the Study of the Lumbar Spine. 34th Annual Meeting. Hong Kong June 10-14 . 2007. |
|
Leung H.B., Tseng H., Lu W.W., Cheung K.M.C. and Luk K.D.K., Pullout strength of screws from bioactive bone cement versus polymethylmethacrylate bone cement, 26th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 11-12, 2006. |
|
Leung Y.L., Wu E.X., Luk K.D.K., Chan D. and Cheung K.M.C., Allogeneic mesenchymal stem cell transplantation into the intervertebral disc: effect of severity of degeneration and cell number on regeneration, The Annual Meeting of the International Society for the Study of the Lumbar Spine. 2007. |
|
Leung Y.L., Wu E.X., Luk K.D.K., Chan D. and Cheung K.M.C., Regeneration of degenerated intervertebral disc using allogeneic Mesenchymal stem cells encapsulated in self-assembling peptide hydrogel, 53rd Annual Meeting of the Orthopaedic Research Society. 2007. |
|
Li Z., Lam R.W.M., Yang C., Xu B., Ni G., Abbah S.A., Cheung K.M.C., Luk K.D.K. and Lu W.W., Chemical composition, crystal size and lattice structural changes after incorporation of strontium into biomimetic apatite, Biomaterials. 2007, 28(7): 1452-60. |
|
Liu X., Wu S., Chan Y.L., |
|
Liu X.M., Wu S.L., |
|
Liu X.M., Wu S.L., |
|
Luk K.D.K., A novel spinal implant for progressive scoliosis correction, BME 2006 Conference, Hong Kong, September 21-23, 2006. 2006. |
|
Luk K.D.K., Bioactivity and corrosion resistance of niti after calcium plasma immersion ion implantation, CME Course on Spinal Deformity, Nanjing, PR China, June 14-19, 2007. 2007. |
|
Luk K.D.K., Cervical myelopathy: patient evaluation and natural history, AOSpine Interactive Course, Davos, Switzerland, December 11-15, 2006. 2006. |
|
Luk K.D.K., Cervical spondylotic myelopathy, 13th APOA Operative Spine Course, Coimbatore, India, March 8-11, 2007. 2007. |
|
Luk K.D.K., Complications: acute infection after spinal instrumentation, AOSpine Interactive Course, Davos, Switzerland, December 11-15, 2006. 2006. |
|
Luk K.D.K., Congenital scoliosis, 4th Hong Kong International Orthopaedic Forum, Hong Kong, April 21-22, 2007. 2007. |
|
Luk K.D.K., Correction of non-traumatic spinal deformity, Combined Scientific Meeting of AOA and NZOA, Canberra, Australia, October 8-13, 2006 . 2006. |
|
Luk K.D.K., Deciding fusion levels in scoliosis, 13th APOA Operative Spine Course, Coimbatore, India, March 8-11, 2007. 2007. |
|
Luk K.D.K., Disc transplantation: from animal experiment to human clinical trial, Combined Scientific Meeting of AOA and NZOA, Canberra, Australia, October 8-13, 2006. 2006. |
|
Luk K.D.K., Interveretebral disc transplantation - from laboratory to clinical trial, 1st Macau Orthopaedic Forum, Macau, September 24, 2006. 2006. |
|
Luk K.D.K. and Ruan D., Intervertebral disc transplant and implantation method, PCT Patent Application No.: PCT/CN2007/002024 filed June 28, 2007. 2007. |
|
Luk K.D.K. and Ruan D., Intervertebral disc transplantation: from animal study to pilot human trial, 1st International Congress of Chinese Orthopaedic Association, Beijing, PR China, November 12-15, 2006. 2006. |
|
Luk K.D.K. and Ruan D., Intervertebral disc transplantation, US Patent Application No. 60/820,378 filed July 26, 2006. 2006. |
|
Luk K.D.K., Joint Conference of HKPA, HKARM and HKCOS, Hong Kong, October 14-15, 2006. 2006. |
|
Luk K.D.K., Management of spinal TB - historial perspective and future directions, Combined Scientific Meeting of AOA and NZOA, Canberra, Australia, October 8-13, 2006 . 2006. |
|
Luk K.D.K., New frontiers in spine surgery, AOSpine Basic Course, Kuala Lumpur, Malaysia, July 7-9, 2006. 2006. |
|
Luk K.D.K., Present status of steroid usage in spinal cord injury, Fourth SICOT/SIROT Annual International Conference, Buenos Aires, Argentina, August 23-26, 2006. 2006. |
|
Luk K.D.K., Role of instrumentation, AOSpine Interactive Course for Operating Room Personnel, Kuala Lumpur, Malaysia, July 9-10, 2006. 2006. |
|
Luk K.D.K., Spondylodiscitis: conservative treatment, AOSpine Interactive Course, Davos, Switzerland, December 11-15, 2006. 2006. |
|
Luk K.D.K., The future treatment of degenerative disc disease will be biological not surgical biological approach to motion preservation in the spine, Combined Scientific Meeting of AOA and NZOA, Canberra, Australia, October 8-13, 2006 . 2006. |
|
Luk K.D.K., Total en bloc spondylectomy - how I do it, Fourth SICOT/SIROT Annual International Conference, Buenos Aires, Argentina, August 23-26, 2006. 2006. |
|
Luk K.D.K. and Lu D., 兒童脊柱結核的後凸畸形, In: 吳啟秋及林羽 主編,, 骨關節結核 (Tuberculosis of Bone and Joint. PR China, 人民衛生出版社, 2006, 1: 197-206. |
|
Mak J.N.F., Hu Y. and Luk K.D.K., ICA-based ECG removal from Surface Electrography and its effect on Low Back Pain Assessment, The 3rd International IEEE EMBS Conference on Neural Engineeering. Kohala Coast, Hawaii, USA. (2-5 May, 2007). 2007, 646-9. |
|
Ng M.C., Ho J.T., Ho S.L., Lee R., Li G., Cheng T.S., Song Y.Q., Kwok H.H., Ho W.L., Chu C.Y.A., Fong C.Y., Chan K.H., Cheung R.T.F., Li L.S.W., Yang E.S., Luk K.D.K., Hu Y., Ramsden D.B. and Leong Fung L.L.Y., MR-DTI study: abnormal water diffusion pattern in asymptomatic familial amyotrophic lateral sclerosis with SOD1 mutation, Second International Symposium on Healthy Aging: Meeting the Challenges of an Aging Population. 2007, 54. |
|
Ni G., Lu W.W., XU B., Chiu P.K.Y., Yang C., Li Z., Lam R.W.M. and Luk K.D.K., Interfacial behaviour of strontium-containing hydroxyapatite cement with cancellous and cortical bone, Biomaterials. 2006, 27: 5127-5133. |
|
Ni G., Lu W.W., Ngan A.H.W. and Luk K.D.K., Nanomechanics of bone and bioactive bone-cement interfaces, In: Ling Qin, Harry K. Genant, James Griffith, Kwok-Sui Leung, Advanced Bioimaging Technologies in Assessment of the Quality of Bone and Scaffold Materials Techniques and Applications. Springer, 2007, 613-625. |
|
Ni G., Chiu P.K.Y., Lu W.W., Wang Y., Zhang Y.G., Hao L., Li Z., Lam R.W.M. and Luk K.D.K., Strontium-containing hydroxyapatite bioactive bone cement in revision hip arthroplasty, Biomaterials. 2006, 27: 4348-4355. |
|
Ruan D., He Q., Ding Y., Hou L.S., Li J.Y. and Luk K.D.K., Intervertebral disc transplantation: a new dimension in the treatment of degenerative spinal disease, 34th Annual Meeting of International Society for the Study of the Lumbar Spine, Hong Kong, June 10-14, 2007. |
|
Senkoylu
A., Wong Y.W., Luk K.D.K. and Cheung K.M.C., Prognosis of spontaneous
thoracic curve correction after the isolated anterior fusion of Lenke |
|
Song Y., Cheung K.M.C., Ho D.W.H., Chiba K., Kawaguchi Y., Hirose Y., Alini M., Yee A.F.Y., Poon S.C.S., Leong J.C.Y., Luk K.D.K., Yip S.P., Karppinen J., Cheah K.S.E., Sham P.C., Ikegawa S. and Chan D., Association of the Asporin D14 allele to lumbar disc degeneration in Chinese and Japanese., Gordon Research Conference on Cartilage Biology and Pathology, March 4-9, 2007, Ventura, CA, USA. 2007. |
|
Song Y., Cheung K.M.C., Fan B., Karppinen J., Yip S.P., Leong J.C.Y., Luk K.D.K., Ott J., Cheah K.S.E., Sham P.C. and Chan D., SNP-SNP Interaction in Intervertebral Disc Disease with Genes in the Aggrecan Degradation Pathway, The 8th International Meeting on Human Genome Variation and Complex Genome Analysis. Le Meridien Cyberport Hotel and Convention Centre, Hong Kong SAR, China. 14 Sept-16 Sept . 2006. |
|
Soon H.C., Cheung K.M.C., Bullmann V., Senkoylu A., Halm H.F., Wong Y.W., Liljenqvist U.R. and Luk K.D.K., Comparative sagittal plane correction after anterior single rod versus dual rod instrumentation in idiopathic thoracolumbar and lumbar scoliosis, 26th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 11-12, 2006. |
|
Tong H.W., Wang M., Lu W.W., Cheung K.M.C., Yeung K.W.K. and Luk K.D.K., Pedicle screws and rods made of a shape memory alloy for treating scoliotic patients, Proceedings of the Biomedical Engineering Conference BME2006. Hong Kong, HKIE, 127-130. |
|
Tsui K.M., Zhang Z.G., Chan S.C., Hu Y. and Luk K.D.K., On the Time-frequency Analysis of Trunk Muscles During Sudden Release of Load, 2007 IEEE International Symposium on Circuits and Systems Proceedings. 2007, May. New Orleans. 2007, 1309-12. |
|
Tsui K.M., Zhang Z., Chan S.C., Hu Y. and Luk K.D.K., On the Time-frequency Analysis of Trunk Muscles During Sudden Release of Load, Proc. IEEE Int'l Symposium on Ciruits and Systems (ISCAS'2007). 2007, 1309-1312. |
|
Virtanen I.M., Song Y., Cheung K.M.C., Ala-Kokko L., Karppinen J., Ho D.W.H., Luk K.D.K., Yip S.P., Leong J.C.Y., Cheah K.S.E., Sham P.C. and Chan D., Phenotypic and Population Differences in the Association between CILP and Lumbar Disc Disease., Journal of Medical Genetics. 2007, 44(4): 285-8. |
|
Wong K.W.N., Luk K.D.K., Leong J.C.Y. and Lu W.W., Lumbar segmental motion patterns in patients with degenerative spondylolisthesis were detected with digital videofluoroscopic videos and distortion compensated Roentgen Analysis System, 34th Annual Meeting of International Society for the Study of the Lumbar Spine, Hong Kong, June 10-14, 2007. |
|
Wong Y.W., Cheung K.M.C. and Luk K.D.K., Acute spinal cord or cadua equina compression by epidural hematoma: review of 7 cases, 26th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 11-12, 2006. |
|
Yang F., Cheung K.M.C., Lu W.W., Leung Y.L., Chan D. and Luk K.D.K., A Simple Annular Puncture Model Of Disc Degeneration In The Mouse Tail, International Society for the Study of the Lumbar Spine. 34th Annual Meeting. Hong Kong June 10-14 . 2007. |
|
Yang F., Chan D., Leong V.Y.L., Lu W.W., Luk K.D.K. and Cheung K.M.C., A Simple Novel Annular Puncture Model of Disc Degeneration in the Mouse Tail., 11th Research Postgraduate Symposium, 7 Dec. 2006. The University of Hong Kong, Li Ka Shing Faculty of Medicine. 2006. |
|
Yeung K.W.K., Lu W.W., Luk K.D.K. and Cheung K.M.C., A novel "smart" spinal impact locking mechanism based on nickel-titanium alloy., Spine. 2006, 31(20): 2296-2303. |
|
Yeung
K.W.K., Chan Y.L., Lam K.O., Liu X.Y., Chung C.Y., |
|
Yeung
K.W.K., Poon R.W.Y., Chung C.Y., Liu X.Y., |
|
Yeung
K.W.K., Wu S.L., Liu X.M., Chung C.Y., |
|
Yeung
K.W.K., Lam K.O., Chan Y.L., Wu S.L., Liu X.Y., Chung
C.Y., |
|
Yeung
K.W.K., Chan Y.L., Lam K.O., Liu X.Y., Chung C.Y., |
|
Researcher
: Mak JNF |
|
List of Research Outputs |
|
Hu Y., Mak J.N.F., Liu H. and Luk K.D.K., ECG Cancellation for Surface Electromyography Measurement Using Independent Component Analysis, 2007 IEEE International Symposium on Circuits and Systems Proceedings. 2007, May. New Orleans. 2007, 3235-8. |
|
Hu Y., Mak J.N.F., Lu W.W. and Luk K.D.K., Surface Electrography Topography As An Assessment for Low Back Pain Rehabilitation, The 3rd International IEEE EMBS Conference on Neural Engineeering. Kohala Coast, Hawaii, USA (2-5 May 2007). 2007, 557-60. |
|
Mak J.N.F., Hu Y. and Luk K.D.K., ICA-based ECG removal from Surface Electrography and its effect on Low Back Pain Assessment, The 3rd International IEEE EMBS Conference on Neural Engineeering. Kohala Coast, Hawaii, USA. (2-5 May, 2007). 2007, 646-9. |
|
Researcher
: Ng FY |
|
List of Research Outputs |
|
Ng F.Y., Zhu Y. and Chiu P.K.Y., Cementless acetabular component inserted without screws - the effect of immediate weight bearing , International Orthopaedics. 2007, 31: 293-296. |
|
Researcher
: Ng KH |
|
List of Research Outputs |
|
Ng K.H., Updates in fractrures around the foot, AO Seminar Hong Kong - Controversies in modern fracture management, Hong Kong, 23-24 September 2006. |
|
Researcher
: Ng MC |
|
List of Research Outputs |
|
Wu Y., Tang H., Ng M.C., Yang J., Tse H.F., Lau C.P., Yang E.S. and Wu E.X., Study of myocardial fiber length distribution with diffusion tensor MRI, 2006 Proceedings of International Society of Magnetic Resonance in Medicine. 2006, 1222. |
|
Researcher
: Ng TP |
|
List of Research Outputs |
|
Liu K.G., Qu G.Y., Zhang S.D., Tang W.M., Ng T.P. and Yau W.P., Total hip arthroplasties with tapered titanium - alloy cememtless femoral components, 錐形鈦合金非骨水泥股骨柄全髋關節置換術34例隨訪一年X綫結果分析, Chinese Journal of Bone and Joint Injury. 2007, 22(4): 274-276. |
|
Ng T.P., Lai A., Wong L., Ting A.C.W. and Chiu P.K.Y., Unusual cause of deep vein thrombosis - Iliopsoas bursa compressing the femoral vein, The 26th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2006, 10: S93. |
|
Tang W.M., Chiu P.K.Y., Kwan M.F.Y. and Ng T.P., Sagittal pelvic mal-rotation and positioning of the acetabular component in total hip arthroplasty: three-dimensional computer model analysis, Journal of Orthopaedic Research. 2007, 25(6): 766-771. |
|
Yan C.H., Yau P.W.P., Ng T.P., Lie W.H., Chiu P.K.Y. and Tang W.M., Inter-observer and intra-observer errors in obtaining transepicondylar axis and Whiteside line in total knee arthroplasty, The 26th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2006, 10: S99. |
|
Yan C.H., Yau P.W.P., Ng T.P., Lie W.H., Chiu P.K.Y. and Tang W.M., Inter-observer and intra-observer errors in obtaining transepicondylar axis and Whiteside line in total knee arthroplasty, The Eighth National Congress of Orthopaedic Surgery and the First International Congress of Chinese Orthopaedic Association, November 13-15, 2006. 56. |
|
Yau P.W.P., Chiu P.K.Y., Tang W.M. and Ng T.P., Coronal bowing of the femur and tibia in Chinese: Its incidence and effects on total knee arthroplasty planning, Journal of Orthopaedic Surgery. 2007, 15: 32-36. |
|
Yau P.W.P., Chiu P.K.Y., Tang W.M. and Ng T.P., Factors affecting the alignment of the implanted prosthesis in computer navigation total knee replacement, The 4th Annual Meeting of Asian Society for Computer Assisted Orthopaedic Surgery, March 30-31, 2007, Seoul, Korea. 2007. |
|
Yau P.W.P., Chiu P.K.Y., Tang W.M. and Ng T.P., The residual posterior femoral condyle osteophyte - Will it affect flexion range after total knee arthroplasty, 6th Annual Scientific Symposium. Orthopaedic Update: "Clinical options for younger patients". January 10-13, 2007, Kuala Lumpur, Malaysia. . 2007. |
|
Yeung Y., Chiu P.K.Y., Yau P.W.P., Tang W.M., Cheung W.Y. and Ng T.P., Assessment of the proximal femoral morphology using plain radiograph - can it predict the bone quality?, The Journal of Arthroplasty. 2006, 21(4): 508-513. |
|
Researcher
: Ni G |
|
List of Research Outputs |
|
Li Z., Lam R.W.M., Yang C., Xu B., Ni G., Abbah S.A., Cheung K.M.C., Luk K.D.K. and Lu W.W., Chemical composition, crystal size and lattice structural changes after incorporation of strontium into biomimetic apatite, Biomaterials. 2007, 28(7): 1452-60. |
|
Ni G., Lu W.W., XU B., Chiu P.K.Y., Yang C., Li Z., Lam R.W.M. and Luk K.D.K., Interfacial behaviour of strontium-containing hydroxyapatite cement with cancellous and cortical bone, Biomaterials. 2006, 27: 5127-5133. |
|
Ni G., Lu W.W., Ngan A.H.W. and Luk K.D.K., Nanomechanics of bone and bioactive bone-cement interfaces, In: Ling Qin, Harry K. Genant, James Griffith, Kwok-Sui Leung, Advanced Bioimaging Technologies in Assessment of the Quality of Bone and Scaffold Materials Techniques and Applications. Springer, 2007, 613-625. |
|
Ni G., Chiu P.K.Y., Lu W.W., Wang Y., Zhang Y.G., Hao L., Li Z., Lam R.W.M. and Luk K.D.K., Strontium-containing hydroxyapatite bioactive bone cement in revision hip arthroplasty, Biomaterials. 2006, 27: 4348-4355. |
|
Researcher
: Ni G |
|
List of Research Outputs |
|
Li Z., Lam R.W.M., Yang C., Xu B., Ni G., Abbah S.A., Cheung K.M.C., Luk K.D.K. and Lu W.W., Chemical composition, crystal size and lattice structural changes after incorporation of strontium into biomimetic apatite, Biomaterials. 2007, 28(7): 1452-60. |
|
Ni G., Lu W.W., XU B., Chiu P.K.Y., Yang C., Li Z., Lam R.W.M. and Luk K.D.K., Interfacial behaviour of strontium-containing hydroxyapatite cement with cancellous and cortical bone, Biomaterials. 2006, 27: 5127-5133. |
|
Ni G., Lu W.W., Ngan A.H.W. and Luk K.D.K., Nanomechanics of bone and bioactive bone-cement interfaces, In: Ling Qin, Harry K. Genant, James Griffith, Kwok-Sui Leung, Advanced Bioimaging Technologies in Assessment of the Quality of Bone and Scaffold Materials Techniques and Applications. Springer, 2007, 613-625. |
|
Ni G., Chiu P.K.Y., Lu W.W., Wang Y., Zhang Y.G., Hao L., Li Z., Lam R.W.M. and Luk K.D.K., Strontium-containing hydroxyapatite bioactive bone cement in revision hip arthroplasty, Biomaterials. 2006, 27: 4348-4355. |
|
Researcher
: Ning C |
|
List of Research Outputs |
|
Ning C., Wang Y., Lu W.W., Qiu Q.X., Lam R.W.M., Chen X.F., Chiu P.K.Y., Ye J.D., Wu G., Wu Z.H. and Chow S.P., Nano-structural bioactive gradient coating fabricated by computer controlled plasma-spraying technology , Journal of Materials Science. Materials in Medicine. 2006, 17(10): 875-884. |
|
Researcher
: Ruan D |
|
List of Research Outputs |
|
Luk K.D.K. and Ruan D., Intervertebral disc transplant and implantation method, PCT Patent Application No.: PCT/CN2007/002024 filed June 28, 2007. 2007. |
|
Luk K.D.K. and Ruan D., Intervertebral disc transplantation: from animal study to pilot human trial, 1st International Congress of Chinese Orthopaedic Association, Beijing, PR China, November 12-15, 2006. 2006. |
|
Luk K.D.K. and Ruan D., Intervertebral disc transplantation, US Patent Application No. 60/820,378 filed July 26, 2006. 2006. |
|
Ruan D., He Q., Ding Y., Hou L.S., Li J.Y. and Luk K.D.K., Intervertebral disc transplantation: a new dimension in the treatment of degenerative spinal disease, 34th Annual Meeting of International Society for the Study of the Lumbar Spine, Hong Kong, June 10-14, 2007. |
|
Researcher
: Senkoylu A |
|
List of Research Outputs |
|
Bullmann V., Cheung K.M.C., Halm H.H.F., Senkoylu A., Luk K.D.K. and Liljenqvist U.R., Comparative sagittal plane correction after anterior single rod versus dual rod instrumentation in idiopathic thoracolumbar and lumbar scoliosis, EuroSpine 2006, Istanbul, Turkey, October 25-28, 2006. |
|
Cheung K.M.C., Bullmann V., Senkoylu A., Halm H.F.H., Wong Y.W., Luk K.D.K. and Liljenqvist U.R., Comparative sagittal plane correction after anterior single rod versus dual rod instrumentation in idiopathic thoracolumbar and lumbar scoliosis, 41st Annual Meeting of the Scoliosis Research Society, Monterey, California, September 13-16, 2006. |
|
Senkoylu
A., Wong
Y.W., Luk K.D.K. and Cheung K.M.C., Prognosis of spontaneous
thoracic curve correction after the isolated anterior fusion of Lenke |
|
Soon H.C., Cheung K.M.C., Bullmann V., Senkoylu A., Halm H.F., Wong Y.W., Liljenqvist U.R. and Luk K.D.K., Comparative sagittal plane correction after anterior single rod versus dual rod instrumentation in idiopathic thoracolumbar and lumbar scoliosis, 26th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 11-12, 2006. |
|
Researcher
: Soon HC |
|
List of Research Outputs |
|
Soon H.C., Cheung K.M.C., Bullmann V., Senkoylu A., Halm H.F., Wong Y.W., Liljenqvist U.R. and Luk K.D.K., Comparative sagittal plane correction after anterior single rod versus dual rod instrumentation in idiopathic thoracolumbar and lumbar scoliosis, 26th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 11-12, 2006. |
|
Researcher
: Tang WM |
|
Project Title: |
The alteration of CIP1/WAF1 gene in osteosarcoma: correlation with bone destruction, p53 expression, cell proliferation, cell cycle and clinical data |
|
Investigator(s): |
Tang WM, Chung SSM, Chiu PKY, Liao WM, Chow SP |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
University Research Committee / Committee on Research and Conference Grants - General Award |
|
Start Date: |
07/1997 |
|
Abstract: |
|
To investigate the role of the tumour suppressor gene: CIP1/WAF1 on the pathogenesis and aggressiveness on osteosarcoma; to examine the behaviour of osteosarcoma at the molecular level. |
|
Project Title: |
Enhancement of experimental fracture healing in using tradition Chinese medicine |
|
Investigator(s): |
Tang WM, |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Low Budget High Impact Programme |
|
Start Date: |
11/2001 |
|
Abstract: |
|
To determine the effect of these TCM prescriptions on fracture healing in a experimental fracture animal model. |
|
List of Research Outputs |
|
Fang D. and Tang W.M., The world is In need of an Asian Knee., The 26th Annual Congress of Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery, 2006. |
|
Ho Y.W., Yeung J.S., Chiu P.K., Tang W.M., Lin Z.B. and Lau W.C.S., Ganoderma lucidum polysaccharide peptide reduced the production of proinflammatory cytokines in activated rheumatoid synovial fibroblast, Journal of Molecular and Cellular Biochemistry. 2007, 301(1-2): 173-179. |
|
Liu K.G., Qu G.Y., Zhang S.D., Tang W.M., Ng T.P. and Yau W.P., Total hip arthroplasties with tapered titanium - alloy cememtless femoral components, 錐形鈦合金非骨水泥股骨柄全髋關節置換術34例隨訪一年X綫結果分析, Chinese Journal of Bone and Joint Injury. 2007, 22(4): 274-276. |
|
Tang W.M. and Chiu P.K.Y., Avascular Necrosis in SARS , RCSE & CSHK Conjoint Scientific Congress, 12 October, 2006, Hong Kong. 2006. |
|
Tang W.M. and Chiu P.K.Y., Classification of TKA implants, Yantai Joint Replacement Course 2006. 2006. |
|
Tang W.M., Joint Replacement – A myth or a must? , Dedicated CME Program for Non-fellow. 2006. |
|
Tang W.M. and Chiu P.K.Y., Knee Biomechanic, Yantai Joint Replacement Course 2006. 2006. |
|
Tang W.M., Necrotizing Fasciitis , HKCOS Exit Examination, Preparatory Course, Didactic Lecture . 2007. |
|
Tang W.M. and Chiu P.K.Y., Revision TKA, Yantai Joint Replacement Course 2006. 2006. |
|
Tang W.M., Chiu P.K.Y., Kwan M.F.Y. and Ng T.P., Sagittal pelvic mal-rotation and positioning of the acetabular component in total hip arthroplasty: three-dimensional computer model analysis, Journal of Orthopaedic Research. 2007, 25(6): 766-771. |
|
Tang W.M., Well-fixed Cup, Worn-out insert, CME Meeting, Association of Private Orthopaedic Surgeons, Island Shangri-La Hotel. 2006. |
|
Yan C.H., Yau P.W.P., Ng T.P., Lie W.H., Chiu P.K.Y. and Tang W.M., Inter-observer and intra-observer errors in obtaining transepicondylar axis and Whiteside line in total knee arthroplasty, The 26th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2006, 10: S99. |
|
Yan C.H., Yau P.W.P., Ng T.P., Lie W.H., Chiu P.K.Y. and Tang W.M., Inter-observer and intra-observer errors in obtaining transepicondylar axis and Whiteside line in total knee arthroplasty, The Eighth National Congress of Orthopaedic Surgery and the First International Congress of Chinese Orthopaedic Association, November 13-15, 2006. 56. |
|
Yau P.W.P., Chiu P.K.Y., Tang W.M. and Ng T.P., Coronal bowing of the femur and tibia in Chinese: Its incidence and effects on total knee arthroplasty planning, Journal of Orthopaedic Surgery. 2007, 15: 32-36. |
|
Yau P.W.P., Chiu P.K.Y. and Tang W.M., Factors affecting the alignment of the implanted prosthesis in computer navigation total knee replacement. How precise is the determination of rotational alignment of the femoral prosthesis in total knee replacement?, The 4th Annual Meeting of Aisan Society for Computer Assisted Orthopaedic Surgery, March 30-31, 2007, Seoul, Korea. 2007. |
|
Yau P.W.P., Chiu P.K.Y., Tang W.M. and Ng T.P., Factors affecting the alignment of the implanted prosthesis in computer navigation total knee replacement, The 4th Annual Meeting of Asian Society for Computer Assisted Orthopaedic Surgery, March 30-31, 2007, Seoul, Korea. 2007. |
|
Yau P.W.P., Chiu P.K.Y. and Tang W.M., How precise is the determination of rotational alignment of the femoral prosthesis in total knee replacement?, The 4th Annual Meeting of Asian Society for Computer Assisted Orthopaedic Surgery. March 30-31, 2007, Seoul, Korea. 2007. |
|
Yau P.W.P., Chiu P.K.Y., Tang W.M. and Ng T.P., The residual posterior femoral condyle osteophyte - Will it affect flexion range after total knee arthroplasty, 6th Annual Scientific Symposium. Orthopaedic Update: "Clinical options for younger patients". January 10-13, 2007, Kuala Lumpur, Malaysia. . 2007. |
|
Yeung Y., Chiu P.K.Y., Yau P.W.P., Tang W.M., Cheung W.Y. and Ng T.P., Assessment of the proximal femoral morphology using plain radiograph - can it predict the bone quality?, The Journal of Arthroplasty. 2006, 21(4): 508-513. |
|
Researcher
: Tsui YK |
|
List of Research Outputs |
|
Leong V.Y.L., Hung S.C., Tsui Y.K., Lee M.K., Li L.C., Lo G.G., Masuda K., Wu E.X., Luk K.D.K., Chan D. and Cheung K.M.C., Allogenic Mesenchymal Stem Cell Transplantation Into The Intervertebral Disc: Effect Of Severity Of Degeneration And Cell Number On Regeneration , International Society for the Study of the Lumbar Spine. 34th Annual Meeting. Hong Kong June 10-14 . 2007. |
|
Researcher
: Wang Y |
|
List of Research Outputs |
|
Ni G., Chiu P.K.Y., Lu W.W., Wang Y., Zhang Y.G., Hao L., Li Z., Lam R.W.M. and Luk K.D.K., Strontium-containing hydroxyapatite bioactive bone cement in revision hip arthroplasty, Biomaterials. 2006, 27: 4348-4355. |
|
Ning C., Wang Y., Lu W.W., Qiu Q.X., Lam R.W.M., Chen X.F., Chiu P.K.Y., Ye J.D., Wu G., Wu Z.H. and Chow S.P., Nano-structural bioactive gradient coating fabricated by computer controlled plasma-spraying technology , Journal of Materials Science. Materials in Medicine. 2006, 17(10): 875-884. |
|
Researcher
: Wong CT |
|
List of Research Outputs |
|
Lam R.W.M., Cheung K.M.C., Lu W.W., Luk K.D.K. and Wong C.T., Bone Composition and Crystal Structure after Strontium Treatment for Osteoporosis Goat Model. , Young Investigator Award, 8th Regional Osteoporosis Conference, The Osteoporosis Society of Hong Kong. . 2007. |
|
Researcher
: Wong YW |
|
List of Research Outputs |
|
Cheung K.M.C., Bullmann V., Senkoylu A., Halm H.F.H., Wong Y.W., Luk K.D.K. and Liljenqvist U.R., Comparative sagittal plane correction after anterior single rod versus dual rod instrumentation in idiopathic thoracolumbar and lumbar scoliosis, 41st Annual Meeting of the Scoliosis Research Society, Monterey, California, September 13-16, 2006. |
|
Cheung K.M.C., Cheng A.C.S., Cheung W.Y., Chooi Y.S., Wong Y.W. and Luk K.D.K., Right hip adduction deficit is prevalent in patients with adolescent idiopathic scoliosis, 26th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 11-12, 2006. |
|
Cheung W.Y., Wong Y., Cheung K.M.C., Wong Y.W. and Luk K.D.K., Fulcrum bending correct rotational deformity in adolescent idiopathic scoliosis, 26th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 11-12, 2006. |
|
Senkoylu
A., Wong Y.W., Luk K.D.K. and Cheung K.M.C., Prognosis of spontaneous
thoracic curve correction after the isolated anterior fusion of Lenke |
|
Soon H.C., Cheung K.M.C., Bullmann V., Senkoylu A., Halm H.F., Wong Y.W., Liljenqvist U.R. and Luk K.D.K., Comparative sagittal plane correction after anterior single rod versus dual rod instrumentation in idiopathic thoracolumbar and lumbar scoliosis, 26th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 11-12, 2006. |
|
Wong Y.W., Cheung K.M.C. and Luk K.D.K., Acute spinal cord or cadua equina compression by epidural hematoma: review of 7 cases, 26th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 11-12, 2006. |
|
Researcher
: Yang F |
|
List of Research Outputs |
|
Yang F., Cheung K.M.C., Lu W.W., Leung Y.L., Chan D. and Luk K.D.K., A Simple Annular Puncture Model Of Disc Degeneration In The Mouse Tail, International Society for the Study of the Lumbar Spine. 34th Annual Meeting. Hong Kong June 10-14 . 2007. |
|
Yang F., Chan D., Leong V.Y.L., Lu W.W., Luk K.D.K. and Cheung K.M.C., A Simple Novel Annular Puncture Model of Disc Degeneration in the Mouse Tail., 11th Research Postgraduate Symposium, 7 Dec. 2006. The University of Hong Kong, Li Ka Shing Faculty of Medicine. 2006. |
|
Researcher
: Yau ACMC |
|
List of Research Outputs |
|
Ng F.Y., Wong H.L., Yau A.C.M.C. and Chiu P.K.Y., Range of motion of standard and high-flexion posterior stabilized total knee prosthesis, The 26th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2006, 10: S50. |
|
Researcher
: Yau PWP |
|
List of Research Outputs |
|
Cheung K.W., Yau P.W.P., Chiu K.H. and Chiu P.K.Y., Navigated high tibial osteotomy with Vector Vision system., Stiehl JB, Konermann W, Haaker R, DiGioia (Editors): "Navigation and MIS in Orthopaedic Surgery", Springer Verlag, Berlin, Heidelberg. Springer Verlag, Berlin, Heidelberg, 2006, 509-515. |
|
Ng F.Y., Wong H.L., Yau P.W.P. and Chiu P.K.Y., Range of motion of standard and high-flexion posterior stabilized total knee prosthesis, The Eighth National Congress of Orthopaedic Surgery and the First International Congress of Chinese Orthopaedic Association, November 13-15, 2006. 54. |
|
Yan C.H., Yau P.W.P., Ng T.P., Lie W.H., Chiu P.K.Y. and Tang W.M., Inter-observer and intra-observer errors in obtaining transepicondylar axis and Whiteside line in total knee arthroplasty, The 26th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2006, 10: S99. |
|
Yan C.H., Yau P.W.P., Ng T.P., Lie W.H., Chiu P.K.Y. and Tang W.M., Inter-observer and intra-observer errors in obtaining transepicondylar axis and Whiteside line in total knee arthroplasty, The Eighth National Congress of Orthopaedic Surgery and the First International Congress of Chinese Orthopaedic Association, November 13-15, 2006. 56. |
|
Yau P.W.P., 1. Surgical treatment of osteoarthritis of knee 2. Impact of minimal invasive joint replacement surgery 3. Computer assisted technology in total knee replacement, CME lecture for non-fellows, Hong Kong Academy of Medicine, September 20, 2006. 2006. |
|
Yau P.W.P., Chiu P.K.Y., Tang W.M. and Ng T.P., Coronal bowing of the femur and tibia in Chinese: Its incidence and effects on total knee arthroplasty planning, Journal of Orthopaedic Surgery. 2007, 15: 32-36. |
|
Yau P.W.P., Leung A., Liu K.G., Yan C.H., Wong L.L.S. and Chiu P.K.Y., Errors in obtaining visually selected anatomical landmarks during registration process in non-image based navigation assisted TKR: Comparison between minimal incision approach and conventional incision approach , 29th Annual Congress of Singapore Orthopaedic Association -"Frontiers in spinal surgery, paediatric orthopaedics and cartilage regeneration." November 8-11, 2006, Singapore. 2006. |
|
Yau P.W.P., Leung A., Liu K.G., Yan C.H., Wong L.L.S. and Chiu P.K.Y., Errors in obtaining visually selected anatomical landmarks during registration process in non-image based navigation assisted TKR: Comparison between minimal incision approach and conventional incision approach, 29th Annual Congress of Singapore Orthopaedic Association proceedings. 2006, 159-160. |
|
Yau P.W.P., Chiu P.K.Y. and Tang W.M., Factors affecting the alignment of the implanted prosthesis in computer navigation total knee replacement. How precise is the determination of rotational alignment of the femoral prosthesis in total knee replacement?, The 4th Annual Meeting of Aisan Society for Computer Assisted Orthopaedic Surgery, March 30-31, 2007, Seoul, Korea. 2007. |
|
Yau P.W.P., Chiu P.K.Y., Tang W.M. and Ng T.P., Factors affecting the alignment of the implanted prosthesis in computer navigation total knee replacement, The 4th Annual Meeting of Asian Society for Computer Assisted Orthopaedic Surgery, March 30-31, 2007, Seoul, Korea. 2007. |
|
Yau P.W.P., Chiu P.K.Y. and Tang W.M., How precise is the determination of rotational alignment of the femoral prosthesis in total knee replacement?, The 4th Annual Meeting of Asian Society for Computer Assisted Orthopaedic Surgery. March 30-31, 2007, Seoul, Korea. 2007. |
|
Yau P.W.P., Reply to Ogus Cebesoy's letter to the Editor regarding the article "Residual posterior femoral condyle osteophyte affects the flexion range after total knee replacement, International Orthopaedics. 2006, 30: 313. |
|
Yau P.W.P., Chiu P.K.Y., Tang W.M. and Ng T.P., The residual posterior femoral condyle osteophyte - Will it affect flexion range after total knee arthroplasty, 6th Annual Scientific Symposium. Orthopaedic Update: "Clinical options for younger patients". January 10-13, 2007, Kuala Lumpur, Malaysia. . 2007. |
|
Yeung Y., Chiu P.K.Y., Yau P.W.P., Tang W.M., Cheung W.Y. and Ng T.P., Assessment of the proximal femoral morphology using plain radiograph - can it predict the bone quality?, The Journal of Arthroplasty. 2006, 21(4): 508-513. |
|
Researcher
: Yau WP |
|
List of Research Outputs |
|
Liu K.G., Qu G.Y., Zhang S.D., Tang W.M., Ng T.P. and Yau W.P., Total hip arthroplasties with tapered titanium - alloy cememtless femoral components, 錐形鈦合金非骨水泥股骨柄全髋關節置換術34例隨訪一年X綫結果分析, Chinese Journal of Bone and Joint Injury. 2007, 22(4): 274-276. |
|
Researcher
: Yeung KWK |
|
Project Title: |
Development Of Novel Locking Mechanism For Orthopaedic Implants |
|
Investigator(s): |
Yeung KWK, Cheung KMC, Lu WW |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
12/2005 |
|
Completion Date: |
02/2007 |
|
Abstract: |
|
Objective: To develop an automatic locking mechanism based on the super-elastic and memory effects of nickel-titanium (NiTi) alloy. This locking mechanism will reduce the conventional post-operation complications induced by implant loosening. Introduction: All current internal and external orthopaedic implant locking mechanisms involve the tightening of a nut against the rod and screw head to form a coupling. Surgeons are required to apply a torque over the couplings when they lock these conventional implants. However, there are no standard guidelines regarding how much torque one should apply to be able to secure the lock. In most cases, the surgeon locks it as tightly as possible, which often fails to secure the implant in the long term. If the torque is too small, this will affect the overall mechanical stability of the spinal construct. Loss of correction and implant failure may also occur due to inadequate mechanical stability [1]. Furthermore, daily body movements can wear the rod and the locking mechanism (fretting) [2,3]. Fretting will inevitably generate debris and the coupling subsequently becomes loose, thereby resulting in some complications such as implant-induced osteolysis, pseudarthrosis, subacute low-grade implant infection, late operative site pain and abnormal metal concentration in serum [2-5]. Therefore, the invention of a new locking mechanism is needed. Our thought is to develop a novel locking mechanism with a self-retightening ability once fretting occurs. Hopefully, we can achieve this idea through the unique properties found in nickel-titanium (NiTi) alloys - the super-elastic and shape-memory effects. The NiTi material is malleable under cold temperatures, and is able to remember and recover its original shape when heated, hence the term "shape-memory" [7]. Super-elasticity is a state when the force is always constant under deformation strains that range from 1% to 8% [6,8]. The way NiTi works is analogous to how elastic materials such as rubber work, where the recovery force is proportional to the degree of deformation. Our previously patented thermal treatment protocol and paper have shown the ability to optimize the super-elastic and memory effect at human body temperature [9,10]. With the use of these special properties of NiTi alloy, the new locking mechanism may have the ability to automatically retighten once fretting occurs. Therefore, the complications induced by implant loosening can be solved. Hypothesis: A new locking mechanism made out of NiTi alloy which has the unqiue properties of super-elasticity and memory effect has the ability of self-retightening once fretting occurs. Therefore, this new locking mechanism is able to tackle the post-operation complications induced by implant loosening. The key issues are: - the ability to reduce the post-operation complications induced by implant loosening. - to ensure that the hypothesis of self-retightening mechanism is workable and that the lock behaves properly under in-vivo conditions. References: [1] Lim TH, An HS. Biomechanics of spinal instrumentation. In: An HS, Cotler JM, editors. Spinal Instrumentation. Philadelphia: Lippincott Williams & Wilkins; 1999. p 59-72. [2] Senaran H, Atilla P, Kaymaz F, Acaroglu E, Surat A. Ultrastructural Analysis of Metallic Debris and Tissue Reaction Around Spinal Implants in Patients With Late Operative Site Pain. Spine August 1 2004;29(15):1618-1623. [3] Kasai Y, Iida R, Uchida A. Metal Concentrations in the Serum and Hair of Patients With Titanium Alloy Spinal Implants. Spine 2003;28(12):1320-1326. [4] Hallab NJ, Cunningham BW, Jacobs JJ. Spinal Implant Debris-Induced Osteolysis. Spine October 15 2003;28(20S)(Supplement):S125-S138. [5] Wang JC, Yu WD, Sandhu HS, Betts F, Bhuta S, Delamarter RB. Metal Debris From Titanium Spinal Implants. Spine May 1 1999;24(9):899. [6] Liu Y, McCormick PG. Criteria of Transformation Sequences in NiTi Shape Memory Alloys. Materials Transactions 1996;37(4):691-696. [7] Liu Y, Liu Y, Van Humbeeck J. Two-way Shape Memory Effect Developed by Martensite Deformation in NiTi. Acta Materialia 1999;47(1):199-209. [8] Melton KN, Mercier O. The mechanical properties of NiTi-based shape memory alloys. Acta Metallurgica 1981;29(2):393-398. [9] Yeung KWK, Cheung KMC, Lu WW, Chung CY. Optimization of thermal treatment parameters to alter austenitic phase transition temperature of NiTi alloy for medical implant. Materials Science and Engineering A 2004;383(2):213-218. [10] KWK Yeung, KMC Cheung, JCY Chung, WW Lu. Superelastic or Pseudoelastic Nickel Titanium Alloy for Use as Medical Implant by Setting the AF Transition Temperature below Body Temperature. US Non-Provisional Patent (No. 10/827,665). Filed: April 19, 2004. |
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List of Research Outputs |
|
Chan
Y.L., Yeung K.W.K., Ngan A.H.W., Cheung K.M.C., Lu W.W., Luk K.D.K., Liu X.M. and |
|
Chan Y.L.,
Yeung K.W.K., Lu W.W., Ngan A.H.W., Luk K.D.K., Chan D., Wu S.L., Liu X.M., |
|
Cheung K.M.C., Yeung K.W.K., Chung J.C.Y. and Lu W.W., Shape memory material and method of making the same, Japan Non-Provisional Patent No. 2006-523770 filed October 19, 2006. 2006. |
|
Ho J.P.Y., Wu S.L., Poon R.W.Y., Chung
C.Y., Tjong S.C., |
|
Liu X., Wu S., Chan Y.L., |
|
Liu X.M., Wu S.L., |
|
Liu X.M., Wu S.L., |
|
Tong H.W., Wang M., Lu W.W., Cheung K.M.C., Yeung K.W.K. and Luk K.D.K., Pedicle screws and rods made of a shape memory alloy for treating scoliotic patients, Proceedings of the Biomedical Engineering Conference BME2006. Hong Kong, HKIE, 127-130. |
|
Wu S.L., Chung C.Y., Liu X.M., |
|
Yeung K.W.K., Lu W.W., Luk K.D.K. and Cheung K.M.C., A novel "smart" spinal impact locking mechanism based on nickel-titanium alloy., Spine. 2006, 31(20): 2296-2303. |
|
Yeung
K.W.K., Chan
Y.L., Lam K.O., Liu X.Y., Chung
C.Y., |
|
Yeung
K.W.K., Poon R.W.Y., Chung C.Y., Liu X.Y., |
|
Yeung
K.W.K., Wu S.L., Liu X.M., Chung C.Y., |
|
Yeung
K.W.K., Lam
K.O., Chan Y.L., Wu S.L., Liu
X.Y., Chung C.Y., |
|
Yeung
K.W.K., Chan
Y.L., Lam K.O., Liu X.Y., Chung
C.Y., |
|
Researcher
: Yeung Y |
|
List of Research Outputs |
|
Yeung Y. and Chiu P.K.Y., Letter to editor: Assessment of the proximal femoral morphology using plain radiograph - Can it predict the bone quality?, Journal of Arthroplasty. 2007, 22: 297. |
|
Yeung Y. and Leung K.L., Mode of failure of proximal femoral nail fixation in a Chinese population, The First International Congress of Chinese Orthopaedic Association, Beijing, PR China, 12-15 November 2006 . 2006. |
|
Researcher
: Yip DKH |
|
Project Title: |
To evaluate biomechanically the strongest host bone and allograft bone docking site geometry - for application in bone transplant patients undergoing limb salvage surgery |
|
Investigator(s): |
Yip DKH, Chien EP |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Low Budget High Impact Programme |
|
Start Date: |
11/2000 |
|
Abstract: |
|
To find the strongest, bone docking site geometry between the host bone and massive bone allograft in limb salvage patients. |
|
Project Title: |
Biomechanical evaluation of the effect of incomplete cortical erosion of a diaphyseal long bone |
|
Investigator(s): |
Yip DKH |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2002 |
|
Abstract: |
|
To determine the critical failure strength of a diaphyseal long bone which has been eroded by metastatic disease? |
|
Project Title: |
Strength reduction of suture due to abrasion of the interference screw |
|
Investigator(s): |
Yip DKH |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2004 |
|
Abstract: |
|
To compare the failure strength of two types of sutures before and after the abrasive wear by the screw against bone. |
|
List of Research Outputs |
|
Researcher
: Yuen CK |
|
List of Research Outputs |
|
Yuen C.K. and Ip W.Y., The use of bio-corrodible alloys for tissue engineering, 11th Research Postgraduate Symposium, LKS Faculty of Medicine, HKU (Dec 2006) - Program & Abstract. 2006, 99. |
|
Researcher
: Zhao F |
|
List of Research Outputs |
|
Abbah S.A., Lu W.W., Chan D., Cheung K.M.C., Liu W., Zhao F., Li Z., Leong J.C.Y. and Luk K.D.K., In vitro evaluation of alginate encapsulated adipose-tissue stromal cells for use as injectable bone graft substitute., Biochem Biophys Res Commun. 2006, 347(1): 185-91. |
|
Researcher
: Zhou G |
|
Project Title: |
Deciphering the roles of hypoxia-inducible factors in survial and function of intervertebral disc cells |
|
Investigator(s): |
Zhou G, Cheung KMC, Luk KDK, Chan D |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
03/2007 |
|
Abstract: |
|
Hypoxia-inducible factors (HIFs) function
as a master regulator of oxygen homeostasis in metazoan species. HIFs mediate
changes in gene transcription in response to changes in cellular oxygenation.
Many physiological, pathological, and developmental processes are regulated
by the HIF-related pathways. Accumulating evidences suggest that the HIF
pathway plays critical roles in a number musculoskeletal differention and
diseases but little is known about the role of this pathway in regulating
properties and functions of intervertebral disc cells. Degenerative disorders
of the intervertebral disc are common in elderly people wherein the disc
cells decline in both number and activity. This proposal is therefore
desigened to test our hypothesis that the HIFs-mediated mechanism plays a
central role in regulating the survival and functions of intervertebral disc
cells under extremely hypoxic conditions in nature, and the manipulation of
this pathway will facilitate mesenchymal stem cells to differentiate into
disc cell lineages. Accordingly, the particular aims of the proposal are: 1)
to characterize the growth properties of disc cell populations isolated from
rat and humans and cultured in vitro under normoxia and hypoxia; 2) to
investigate the expression pattern of the hypoxia/VHL/HIF axis-related
molecules in healthy and degenerative intervertebral discs from newborn,
young, adult and aged individuals; 3) to analyze the roles of HIF |
|
List of Research Outputs |
|
Zhou G., 2007 Asian Investigator Travel Award: Preclinical and Clinical Trials of a Tissue Engineering Bone Composited with Allogenous Bone Marrow Mesenchymal Stem Cells, International Society for Cell Therapy Annual Meeting. 2007. |
|
Zhou
G., 2007 ISSCR Travel Award: A Novel Role of
SOX |
|
Zhou
G., Zhao L., Rosalyn A. and Li G., A Novel
Role of SOX |
|
Zhou G., Yee A.F.Y., Chan D., Alini M. and Cheung K.M.C., Hypoxia-related and Stem Cell-Like Phenotypes of Young, Adult and Aged Intervertebral Disc Cells, International Society for the Study of the Lumbar Spine. 34th Annual Meeting. Hong Kong June 10-14 . 2007. |
|
Researcher
: Zhu Y |
|
List of Research Outputs |
|
Ng F.Y., Zhu Y. and Chiu P.K.Y., Cementless acetabular component inserted without screws - the effect of immediate weight bearing , International Orthopaedics. 2007, 31: 293-296. |
|
Zhu Y. and Leung K.L., MIPO in distal tibial fractures, The First International Congress of Chinese Orthopaedic Association, Beijing, PR China, 12-15 November 2006 . 2006. |
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