DEPT OF DIAGNOSTIC RADIOLOGY

Researcher : Chan FL

List of Research Outputs

 

Wong R.W.M., Lai K.C., Yiu M.W.C., Wong B.C.Y., Chan F.L. and Lai C.L., Intestinal tuberculosis mimicking fistulizing Crohn's disease, Journal of Gastroenterology and Hepatology. 2007, 22: 137-139.

 

Researcher : Cheung SCW

List of Research Outputs

 

Cheung E.W.Y., Lam W.W.M., Cheung S.C.W. and Cheung Y.F., Functional Implications of the Right Ventricular Myocardial Performance Index in Patients After Surgical Repair of Tetralogy of Fallot, Hong Kong College of Cardioloyg, Fifteenth Annual Scientific Congress Proceedings (Free Paper Session, Paediatric Cardiology I), Hong Kong, 4-6 May 2007. 15: 60.

 

Researcher : Chu FSK

List of Research Outputs

 

Chu F.S.K., Tso W.K. and Lie A.K.W., Percutaneous retrieval of a chronic foreign body with both intravascular and extravascular components, Australasian Radiology. 2007, 51(2): 179-81.

 

Tang S.C.W., Chu F.S.K., Au W.M. and Lai K.N., Emphysematous cystitis, American Journal of Kidney Diseases. 2006, 48: e11-12.

 

Researcher : Khong PL

Project Title:

To establish the use of magnetic resonance imaging for assessing the degree of brain damage following hypoxic ischemic insult with or without neuroprotective therapies

Investigator(s):

Khong PL, Cheung PT

Department:

Diagnostic Radiology

Source(s) of Funding:

Other Funding Scheme

Start Date:

06/2002

 

Abstract:

To evaluate the neuroprotective effects of one purified component of Traditional Chinese Medicine (TCM), caspase inhibitor (CI) and cyclosporin A (CA), in combination or alone.

 

Project Title:

Whole body magnetic resonance (MR) screening in primary plasmacytomas

Investigator(s):

Khong PL, Chim JCS

Department:

Diagnostic Radiology

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

 

Abstract:

To evaluate the clinical utility of whole body MR screening to detect occult lesions in the diagnostic work-up of cases with primary plasmacytomas, including primary solitary bone and extramedullary plasmacytomas.

 

Project Title:

Mapping dose distribution on the Fractional Anisotropy Map: Applications in the assessment of treatment-induced white matter injury

Investigator(s):

Khong PL, Kwong DLW, Chan GCF

Department:

Diagnostic Radiology

Source(s) of Funding:

Small Project Funding

Start Date:

10/2005

 

Abstract:

Treatment-induced neurotoxicity is prevalant and impacts significantly on the lives of childhood brain tumour survivors (Mulhern et al., 2004). Whole brain radiotherapy is considered to be the major contributory factor that causes these deficits (Johnson et al., 1994; Mulhern et al., 1998; Silber et al., 1992). It has been shown that white matter is predisposed to radiation-induced injury and that it may be the substrate of neurocognitive deterioration. There is emerging evidence that diffusion tensor MR imaging (DTI), using fractional anisotropy (FA), is sensitive in detecting and monitoring white matter injury in these patients. (Khong et al., 2005b; Khong et al., 2003; Khong et al., 2005a; Leung et al., 2004b). We aim to explore and describe an optimal method to map whole brain radiation dose distribution to the FA images of childhood brain tumour survivors.

 

Project Title:

Whole body MR imaging of bone marrow in children with Acute Lymphoblastic Leukemia (ALL): evaluation of its role in diagnosis, treatment monitoring and response prediction.

Investigator(s):

Khong PL, Chan GCF, Kwong DLW

Department:

Diagnostic Radiology

Source(s) of Funding:

Small Project Funding

Start Date:

12/2006

 

Abstract:

We aim to determine the role of whole body MRI, a relatively new technique in MRI, in the evaluation of the bone marrow in children with acute lymphoblastic leukaemia (ALL). MRI is the most sensitive technique for the detection of bone marrow pathologies and has become the method of choice for bone marrow imaging. However, prior to the advent of whole body MRI, imaging the marrow has been restricted to selected areas of the bony skeleton because of long imaging times. Recent advances in MRI, particularly the development of fast imaging sequences have significantly reduced imaging times so that the whole body can now be imaged in 15-30 mins without compromising image quality. These advances have led to novel clinical applications of whole body MRI, including tumour staging. To date, there are no reports which have evaluated the role of this new technique in ALL. ALL is the most common tumour in children accounting for about 30% of all newly diagnosed childhood cancer patients. In Hong Kong, there are approximately 40-50 new ALL patients per year. Whole body MRI provides a means for screening the marrow of the entire skeleton, such that the full extent of disease and treatment complications can be evaluated. This is especially important in haematologic disorders which may be spatially heterogeneous like ALL. In a longitudinal study of children diagnosed with ALL, we aim to determine:1)Whole body MRI patterns at diagnosis and subsequent treatment2)If disease load/extent quantified by whole body MRI will contribute to patient management for treatment monitoring and response prediction3)The role of whole body MRI in the screening of early AVN (secondary aim)We hypothesize that this non-invasive technique will provide complementary information to conventional ways of diagnosis and monitoring treatment response i.e. peripheral blood sampling and bone marrow aspiration.We expect to be able to define the clinical usefulness of whole body MRI in leukemia patients. This method of imaging is increasingly available in MRI scanners and especially advantageous in paediatric patients whereby a non-invasive, fast, one-stop imaging modality is desirable

 

Project Title:

Diffusion tensor MRI imaging (DTI) of radiation-induced white matter injury in a rat model

Investigator(s):

Khong PL, Wu EX, Cheung PT, Kwong DLW

Department:

Diagnostic Radiology

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

01/2007

 

Abstract:

To test the following hypotheses: (1) diffusion anisotropy quantitative index, fractional anisotropy (FA) is more sensitive than T2 relaxometry in detecting radiation-induced white matter damage; FA and the diffusion tensor matrix components, radial diffusivity and axial diffusivity, correlate with histological findings of radiation-induced injury, namely demyelination; changes in diffusion anisotropy are dose and time dependent and occur in parallel with histological evidence of demyelination; DTI can accurately detect and monitor the degree of demyelination in-vivo and can be used as a biomarker for the non-invasive evaluation of radiation-induced brain injury.

 

List of Research Outputs

 

Cheung V., Chua S.E., McAlonan G.M., Chen E.Y.H. and Khong P.L., Connectivity along white mater tracts in drug-naive patients of first-episode psychosis: a diffusion tensor tractography study, Hong Kong Society of Biological Psychiatry Conference 2006. Hong Kong Academy of Medicine.

 

Jones D.K., Chitis X.A., Job D., Khong P.L., Leung L.T., Marenco S., Smith S.M. and Symms M.R., What happens when nine different groups analyze the same DT-MRI data set using voxel-based methods?, ISMRM 15th Scientific Meeting & Exhibition, Berlin, Germany,19-25 May 2007. (Proc Intl Soc Mag Reson Med 2007;15:74). 2007.

 

Khong P.L., Advances in paediatric cancer imaging, Cancer Imaging 2007 - Joint Meeting of the International Cancer Imaging Society and Hong Kong College of Radiologists at Hong Kong Academy of Medicine Jockey Club Building, 10-11 February 2007. 2007.

 

Khong P.L., Annals of Neurology, Journal Reviewer. 2007.

 

Khong P.L., Clinical Cancer Research, Journal Reviewer. 2007.

 

Khong P.L., Diffusion tensor imaging in treatment-induced white matter disease. GE Medical Systems Greater China MR Research User Meeting - Diffusion Imaging, Guangzhou, 16 Dec 2006, 2006.

 

Khong P.L., Qiu D., Siok W.T. and Tan L.H., FA and directional diffusivities of normal white matter maturation from late childhood to young adulthood, ISMRM 15th Scientific Meeting & Exhibition, Berlin, Germany,19-25 May 2007 (Proc Intl Soc Mag Reson Med 2007;15:664) . 2007.

 

Khong P.L., Human Brain Mapping, Journal Reviewer. 2007.

 

Khong P.L., Imaging of neonatal encephalopathy, 14th Annual Scientific Meeting of Hong Kong College of Radiologists, Hong Kong, 28 October 2006. 2006.

 

Khong P.L., Imaging-CT, MRI, PET, Head & Neck Course 2007, Department of Surgery, HKU, 7-8 June 2007. 2007.

 

Khong P.L., Journal of Pediaatric Gastroenterology and Nutrition, Journal Reviewer. 2007.

 

Khong P.L., Journal of the Hong Kong College of Radiologists, Associate Editor. 2006.

 

Khong P.L., Pediatric Radiology, Editorial Board. 2007.

 

Khong P.L., Pediatric Radiology, Journal Reviewer. 2007.

 

Khong P.L., Pediatric Research, Journal Reviewer. 2007.

 

Khong P.L., The Hong Kong Journal of Paediatrics, Journal Reviewer. 2007.

 

Khong P.L., The Hong Kong Medical Journal, Journal Reviewer. 2007.

 

Khong P.L., The Journal of the Hong Kong College of Radiologists, Journal Reviewer. 2006.

 

Khong P.L., Ultrasound of hip in paediatric patients, 4th HK International Orthopaedic Forum, Department of Orthopaedics and Traumatology, HKU, 21-22 April 2007. 2007.

 

Khong P.L., Updates in imaging of paediatric oncology, Dedicated CME Programme for Non-Fellows 2007, organized by Hong Kong Academy of Medicine at Queen Elizabeth Hospital, 3 Oct 2007. 2007.

 

Khong P.L., Visualization of neonatal brain using ultrasound, CT scan and MRI: which tool is most appropriate?, 2nd Congress of Asian Society for Pediatric Research, Yokohama, Japan, 8-10 December 2006. 2006.

 

Lau H.F., Hui E.S., Siu H.F., Yang J., Khong P.L. and Wu E.X., In vivo DTI study of developmental rat brain, ISMRM 15th Scientific Meeting & Exhibition, Berlin, Germany,19-25 May 2007. (Proc Intl Soc Mag Reson Med 2007;15:2437). 2007.

 

Qiu D., Khong P.L., Siok W.T. and Tan L.H., Asymmetrical inferior fronto-occipital fasciculus in Chinese children: correlation with Chinese reading, Annual Meeting of International Society for Magnetic Resonance in Medicine. 2007.

 

Qiu D., Khong P.L., Siok W.T. and Tan L.H., Asymmetrical inferior fronto-occipital fasciculus in Chinese children: correlation with Chinese reading, ISMRM 15th Scientific Meeting & Exhibition, Berlin, Germany,19-25 May 2007. (Proc Intl Soc Mag Reson Med 2007;15:3751) . 2007.

 

Qiu D., Kwong D.L.W., Chan G.C.F., Leung L.H.T. and Khong P.L., Diffusion tensor MR imaging finding of discrepant fractional anisotropy between the frontal and parietal lobes after whole-brain irradiation in childhood medulloblastoma survivors: reflection of regional white matter radiosensitivity? , Internal Journal of Radiation Oncology Biology Physics. 2007, 69: 846-851.

 

Wang S., Wu E.X., Wang Y., Lau H., Hui E., Cheung P.T. and Khong P.L., Axial and radial diffusivities as potential markers for characterization of white matter lesions and predicting lesion outcome in a neonatal rat hypoxia-ischemia model, ISMRM 15th Scientific Meeting & Exhibition, Berlin, Germany,19-25 May 2007. (Proc Intl Soc Mag Reson Med 2007;15:3075). 2007.

 

Wang Y., Cheung P.T., Shen G.X., Wu E.X., Qiu D., Khong P.L. and Bhatia I., Comparing diffusion-weighted and T2-weighted MR imaging for the quantification of infarct size in a neonatal rat hypoxic-ischemic model at 24 h post-injury, International Journal of Developmental Neuroscience. Elsevier, 2007, 25: 1-5.

 

Yang J., Ma D., Wang Y., Khong P.L. and Wu E.X., Manganese-enhanced MRI of severe hypoxic-ischemic injuries in neonatal rat model., ISMRM 15th Scientific Meeting & Exhibition, Berlin, Germany,19-25 May 2007. (Proc Intl Soc Mag Reson Med 2007;15:313). 2007.

 

Yung A.W.Y., Poon G.W.K., Qiu D., Chu J., Lam B.C.C., Leung C., Goh W.H.S. and Khong P.L., White matter volume and anisotropy in preterm children: a pilot study of neurocognitive correlates, Pediatric Research. 2007, 61: 732-736.

 

Researcher : Lam TPW

List of Research Outputs

 

Hui P.W., Lam T.P.W., Chan K.L. and Lee C.P., Fetus in fetu – from prenatal suspicion to postnatal confirmation. , The 3rd International Scientific Meeting of the International Society of Ultrasound in Obstetrics & Gynaecology, Hong Kong, 25-28 February 2007.

 

Researcher : Lam WWM

List of Research Outputs

 

Cheung E.W.Y., Lam W.W.M., Cheung S.C.W. and Cheung Y.F., Functional Implications of the Right Ventricular Myocardial Performance Index in Patients After Surgical Repair of Tetralogy of Fallot, Hong Kong College of Cardioloyg, Fifteenth Annual Scientific Congress Proceedings (Free Paper Session, Paediatric Cardiology I), Hong Kong, 4-6 May 2007. 15: 60.

 

Researcher : Lee R

List of Research Outputs

 

Lee R., Lui W.M., Cheung R.T.F., Leung G.K.K. and Chan K.H., Mechanical thrombectomy in acute proximal middle cerebral artery thrombosis with the Alligator Retrieval Device, Cerebrovascular Diseases. 2007, 23: 69-71.

 

Ng M.C., Ho J.T., Ho S.L., Lee R., Li G., Cheng T.S., Song Y.Q., Kwok H.H., Ho W.L., Chu C.Y.A., Fong C.Y., Chan K.H., Cheung R.T.F., Li L.S.W., Yang E.S., Luk K.D.K., Hu Y., Ramsden D.B. and Leong Fung L.L.Y., MR-DTI study: abnormal water diffusion pattern in asymptomatic familial amyotrophic lateral sclerosis with SOD1 mutation, Second International Symposium on Healthy Aging: Meeting the Challenges of an Aging Population. 2007, 54.

 

Tang S.C.W., Lee R., Tse K.C., Lai A.S.H. and Lai K.N., Inability to start hemodialysis after a smooth temporary hemodialysis catheter insertion procedure, Hemodialysis International. 2007, 11: 32-34.

 

Researcher : Leong Fung LLY

List of Research Outputs

 

Ng M.C., Ho J.T., Ho S.L., Lee R., Li G., Cheng T.S., Song Y.Q., Kwok H.H., Ho W.L., Chu C.Y.A., Fong C.Y., Chan K.H., Cheung R.T.F., Li L.S.W., Yang E.S., Luk K.D.K., Hu Y., Ramsden D.B. and Leong Fung L.L.Y., MR-DTI study: abnormal water diffusion pattern in asymptomatic familial amyotrophic lateral sclerosis with SOD1 mutation, Second International Symposium on Healthy Aging: Meeting the Challenges of an Aging Population. 2007, 54.

 

Researcher : Li G

Project Title:

The Neuroprotective Effect of Coenzyme Q10 in AD mice model

Investigator(s):

Li G, Yang ES, Jack Jr CR

Department:

Medical Faculty

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

03/2006

 

Abstract:

Alzheimer's disease (AD) and ischemic cerebrovascular disease are two main causes of dementia in elderly people. Recent basic and clinical investigations demonstrate that AD and vascular dementia (VaD), traditionally considered two independent neurological disorders, may interact in an additive manner. In clinical studies, the presence of ischemic lesions enhances the cognitive deficits in patients with AD pathology. Mutations in the genes of beta-amyloid precursor protein (APP), presenilin 1 (PS1) and presenilin 2 (PS2) cause familial AD. In transgenic mice with overexpressed APP, susceptibility to ischemic brain damage caused by middle cerebral artery occlusion (MCAO) is increased. In AD patients, the extent of AD pathology is increased if ischemic stroke coexists. Elderly subjects are more likely to have been demented in life if both AD pathology and ischemic cerebrovascular disease are present at autopsy than if either is pathology is found in isolation. Several studies suggest a possible role of increased oxidative stress and impairment of mitochondrial energy metabolism in the pathogenesis of both AD and stroke. A number of investigators have identified a deficiency in the complex VI, cytochrome c oxidase (COX) of the mitochondrial electron transport chain in AD patients and a reduced activity of complexes I and III in ischemic conditions. Coenzyme Q10 (CoQ10) is an essential biological cofactor produced endogenously in the body and provided in the food chain. As the electron acceptor for mitochondrial complexes I and II, it has an essential role in cellular energy production as an electron and proton carrier. Complex I or II dysfunction are found in neurological disorders such as Parkinson’s disease and Huntington disease. Shults et al. reported a correlation between mitochondrial CoQ10 level and the biological activity of complexes I - IV Parkinson’s disease patients who were administered the highest dose of CoQ10 showed the greatest clinical benefit. Oral CoQ10 supplementation increases brain mitochondrial concentrations and exerts neuroprotective effects. A neuroprotective effect of CoQ10 has been found in various animal models of stroke and this has been attributed to its role as a potent antioxidant and an oxygen derived free radical scavenger. This finding has not been universally replicated, however, as Li and his colleagues found that immediate treatment with CoQ10 via intraperitoneal injection did not prevent neuronal injuries following global and focal ischemia. Mitochondrial abnormalities have been found in human AD patients, and there are a few reports about the therapeutic effect of CoQ10 in AD patients. Results have been mixed however, for example, de Bustos et al. investigated serum levels of CoQ10 in patients with AD and found no relationship with the risk of AD and vascular dementia. CoQ10 has been shown to have a neuroprotective effect in other neurodegenerative diseases, such as Parkinson’s and Huntington’s diseases. In this study, we address the effects of CoQ10 on AD and cerebral ischemia using volume magnetic resonance imaging (MRI) in transgenic animal models. APP/PS1, APP and PS1 transgenic mice with ischemic stroke will be treated with high-dose CoQ10 for 28 days, and then their brain specimens will be examined by MRI to investigate the neuroprotective effects of CoQ10, compared to the non-treated counterparts. Transgenic rather than wild type mice will be employed in order to amplify the destructive effects of stroke in the experimental animals.

 

Project Title:

Effect of imbalance of kinases and protein phosphatases on deposit of B amyloid and Tau Pathology in double transgenic APP/PS1 Mice

Investigator(s):

Li G, Yang X, Yang ES

Department:

Medical Faculty

Source(s) of Funding:

Germany/Hong Kong Joint Research Scheme

Start Date:

01/2007

 

Abstract:

1. To investigate the effect of the overactivation of GSK-3 on deposit of amyloid and tau pathology in APP/PS1 double transgenic mice 2. To investigate the effect of the suppression of the two major proteins - phosphatase 2A and phosphatase 1 on deposit of amyloid and tau pathology in APP/PS1 double transgenic mice This is the first of systematical study on effects of GSK-3/PP2A and PP1 on the main two defining pathological feature-SPs and tau pathology in transgenic mice

 

Researcher : Ooi CGC

Project Title:

Nasal T/NK-cell lymphoma: CT and MR imaging features of a new clinico-pathological entity: lethal midline granuloma reclassified

Investigator(s):

Ooi CGC, Liang RHS, Kwong YL, Chim JCS

Department:

Diagnostic Radiology

Source(s) of Funding:

Other Funding Scheme

Start Date:

06/1999

 

Abstract:

To describe the radiological features with respect to computed tomography (CT) and magnetic resonance imaging (MRI) of nasal T/NK cell lymphoma; to devise a local (T) tumour staging system and evaluate any correlation with survival and prognosis.

 

Project Title:

Computed tomography (CT) characterization of irreversible asthma with morphologic functional correlation

Investigator(s):

Ooi CGC, Ip MSM, Khong PL

Department:

Diagnostic Radiology

Source(s) of Funding:

Low Budget High Impact Programme

Start Date:

11/2001

 

Abstract:

To characterize CT features of irreversible or end stage asthma; to develop a scoring system to quantify these changes on CT; to correlate lung function with CT score of lung changes; to evaluate whether small airways disease seen on CT is an association of end-stage asthma; to evaluate the significance of bronchial wall thickening in this condition.

 

Project Title:

Prognostic significance of CT-derived tumour volume in oesophageal cancer

Investigator(s):

Ooi CGC, Khong PL

Department:

Diagnostic Radiology

Source(s) of Funding:

Small Project Funding

Start Date:

11/2002

 

Abstract:

To quantify baseline and post chemo-irradiation (post-treatment) tumour volumes (TV) in patients with oesophageal carcinoma using computed tomography (CT); to quantify post-treatment TV based on PET (positron emission tomography)/CT data; to evaluate the relationships between baseline and post-treatment TV, with T-stage, N-stage, overall stage and survival; to evaluate the relationship between SUV (standardised uptake value) uptake in PET and TV; to determine the significance of baseline and post-treatment CT-TV on changes in T and N stage after chemo-irradiation.

 

Project Title:

Clinical utility of radiological assessment of Severe Acute Respiratory Syndrome: a retrospective and prospective study on a cohort of SARS patients

Investigator(s):

Ooi CGC, Tsang KWT, Khong PL

Department:

Diagnostic Radiology

Source(s) of Funding:

VCO SARS Research Fund

Start Date:

07/2003

 

Abstract:

To quantify severity of severe acute respiratory syndrome (SARS) on chest radiograph and to determine its relationship with clinical parameters; to evaluate the predictive value of chest radiographs on oxygen supplementation requirement and treatment response in severe acute respiratory syndrome (SARS); to document serial lung changes on HRCT int he acute and covalescent period; to document and describe irreversible lung changes of HRCT on long term follow-up.

 

Project Title:

HRCT quantification of lung disease in SARS: correlation with clinical parameters and residual disease

Investigator(s):

Ooi CGC, Tsang KWT, Khong PL

Department:

Diagnostic Radiology

Source(s) of Funding:

Small Project Funding

Start Date:

11/2003

 

Abstract:

To validate a commercially available quantitative technique in measuring normal lung volume and volume of lung abnormalities on high resolution CT (HRCT) scans; to correlate disease volume measured on HRCT at or near maximal lung disease as defined on chest radiograph in SARS with clinical parameters such as exercise tolerance, and amount of residual disease 6 months after discharge.

 

List of Research Outputs

 

Ho J.C.M., Chan M.M.W., Ho S.P., Mak J.C.W., Ip M.S.M., Ooi C.G.C., Wong M.P., Tsang K.W.T. and Lam W.K., Disturbance of systemic antioxidant profile in non-small cell lung carcinoma, Eur Respir J . 2007, 29: 273-278.

 

Lam B., Wong M.P., Fung S.L., Lam C.L., Wong P.C., Wong T.Y.W., Lam F.M., Ip M.S.M., Ooi C.G.C. and Lam W.K., The clinical value of autofluorescence bronchoscopy for the diagnosis of lung cancer , European Respiratory Journal. 2006, 28(5): 915-919.

 

Lam J.C., Tam S., Ooi C.G.C., Ku P.P., Lai A.Y.K., Lam B., Lam K.S.L. and Ip M.S.M., Relationship between sympathetic activity, obesity, and obstructive sleep apnea, 8th World Congress on Sleep Apnea. Montreal, Canada. Sleep Medicine. 2006, 7 (suppl 2): S51 (P321).

 

Lam J.C.M., Tam S., Ooi C.G.C., Ku P.P., Lai A.Y.K., Lam B., Lam K.S.L. and Ip M.S.M., Relationship between sympathetic activity, obesity, and obstructive sleep apnea, 8th World Congress on Sleep Apnea. Montreal, Canada, September 2006. Sleep Medicine. 2006, 7 (suppl 2): S51 (P321).

 

Researcher : Qiu D

List of Research Outputs

 

Khong P.L., Qiu D., Siok W.T. and Tan L.H., FA and directional diffusivities of normal white matter maturation from late childhood to young adulthood, ISMRM 15th Scientific Meeting & Exhibition, Berlin, Germany,19-25 May 2007 (Proc Intl Soc Mag Reson Med 2007;15:664) . 2007.

 

Qiu D., Khong P.L., Siok W.T. and Tan L.H., Asymmetrical inferior fronto-occipital fasciculus in Chinese children: correlation with Chinese reading, Annual Meeting of International Society for Magnetic Resonance in Medicine. 2007.

 

Qiu D., Khong P.L., Siok W.T. and Tan L.H., Asymmetrical inferior fronto-occipital fasciculus in Chinese children: correlation with Chinese reading, ISMRM 15th Scientific Meeting & Exhibition, Berlin, Germany,19-25 May 2007. (Proc Intl Soc Mag Reson Med 2007;15:3751) . 2007.

 

Qiu D., Kwong D.L.W., Chan G.C.F., Leung L.H.T. and Khong P.L., Diffusion tensor MR imaging finding of discrepant fractional anisotropy between the frontal and parietal lobes after whole-brain irradiation in childhood medulloblastoma survivors: reflection of regional white matter radiosensitivity? , Internal Journal of Radiation Oncology Biology Physics. 2007, 69: 846-851.

 

Wang Y., Cheung P.T., Shen G.X., Wu E.X., Qiu D., Khong P.L. and Bhatia I., Comparing diffusion-weighted and T2-weighted MR imaging for the quantification of infarct size in a neonatal rat hypoxic-ischemic model at 24 h post-injury, International Journal of Developmental Neuroscience. Elsevier, 2007, 25: 1-5.

 

Yung A.W.Y., Poon G.W.K., Qiu D., Chu J., Lam B.C.C., Leung C., Goh W.H.S. and Khong P.L., White matter volume and anisotropy in preterm children: a pilot study of neurocognitive correlates, Pediatric Research. 2007, 61: 732-736.

 

Researcher : Tai KS

List of Research Outputs

 

McAlonan G.M., Cheung V., Cheung C., Chua S.E., Murphy D.G.M., Suckling J., Tai K.S., Yip L.K.C., Leung P. and Ho T.P., Mapping brain structure in attention deficit-hyperactivity disorder: A voxel-based MRI study of regional grey and white matter volume, Psychiatry Research Neuroimaging. Elsevier, 2006, 154: 171-180.

 

Researcher : Tso WK

List of Research Outputs

 

Chok K.S.H., Ng K.K.C., Poon R.T.P., Lam C.M., Yuen J.H.F., Tso W.K. and Fan S.T., Comparable survival in patients with unresectable hepatocellular carcinoma treated by radiofrequency ablation or transarterial chemoembolization, Archives of Surgery. 2006, 141(12): 1231-1236.

 

Chu F.S.K., Tso W.K. and Lie A.K.W., Percutaneous retrieval of a chronic foreign body with both intravascular and extravascular components, Australasian Radiology. 2007, 51(2): 179-81.

 

Liu C.L., Fan S.T., Lo C.M., Tso W.K., Lam C.M. and Wong J., Improved operative and survival outcomes of surgical treatment for hilar cholangiocarcinoma, British Journal of Surgery. 2006, 93(12): 1488-1494.

 

Ng K.K.C., Poon R.T.P., Lo C.M., Yuen J.H.F., Tso W.K. and Fan S.T., Analysis of recurrence pattern and its influence on survival outcome after radiofrequency ablation of hepatocellular carcinoma (Grassi Prize Finalist Presentation), The 20th World Congress of the International Society for Digestive Surgery 2006, Rome, Italy, 29 November - 2 December 2006. 2006.

 

Ng K.K.C., Poon R.T.P., Lo C.M., Yuen J.H.F., Tso W.K. and Fan S.T., Analysis of recurrence pattern and survival outcome after radiofrequency ablation of hepatocellular carcinoma: a single institution experience (Abstract), Surgical Practice. 2006, 10: A1.

 

Poon R.T.P., Ng K.K.C., Tso W.K., Woo R., Pang R.W.C., Tai K.S. and Fan S.T., A phase I/II trial of transarterial chemoembolization for hepatocellular carcinoma using a novel intrarterial drug eluting beads (Abstract), The 5th International Hepatocellular Carcinoma Meeting: Eastern and Western Experiences, Houston, USA, 11 - 13 January 2007.

 

Researcher : Wang S

List of Research Outputs

 

Wang S., Wu E.X., Wang Y., Lau H., Hui E., Cheung P.T. and Khong P.L., Axial and radial diffusivities as potential markers for characterization of white matter lesions and predicting lesion outcome in a neonatal rat hypoxia-ischemia model, ISMRM 15th Scientific Meeting & Exhibition, Berlin, Germany,19-25 May 2007. (Proc Intl Soc Mag Reson Med 2007;15:3075). 2007.

 

Researcher : Wang Y

List of Research Outputs

 

Wang S., Wu E.X., Wang Y., Lau H., Hui E., Cheung P.T. and Khong P.L., Axial and radial diffusivities as potential markers for characterization of white matter lesions and predicting lesion outcome in a neonatal rat hypoxia-ischemia model, ISMRM 15th Scientific Meeting & Exhibition, Berlin, Germany,19-25 May 2007. (Proc Intl Soc Mag Reson Med 2007;15:3075). 2007.

 

Wang Y., Cheung P.T., Shen G.X., Wu E.X., Qiu D., Khong P.L. and Bhatia I., Comparing diffusion-weighted and T2-weighted MR imaging for the quantification of infarct size in a neonatal rat hypoxic-ischemic model at 24 h post-injury, International Journal of Developmental Neuroscience. Elsevier, 2007, 25: 1-5.

 

Yang J., Ma D., Wang Y., Khong P.L. and Wu E.X., Manganese-enhanced MRI of severe hypoxic-ischemic injuries in neonatal rat model., ISMRM 15th Scientific Meeting & Exhibition, Berlin, Germany,19-25 May 2007. (Proc Intl Soc Mag Reson Med 2007;15:313). 2007.

 

Researcher : Wong Y

List of Research Outputs

 

Cheung W.Y., Wong Y., Cheung K.M.C., Wong Y.W. and Luk K.D.K., Fulcrum bending correct rotational deformity in adolescent idiopathic scoliosis, 26th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 11-12, 2006.

 

Researcher : Wu EX

Project Title:

Magnetic resonance imaging for biomedical research

Investigator(s):

Wu EX

Department:

Engineering Faculty

Source(s) of Funding:

Seed Funding for New Staff

Start Date:

02/2004

 

Abstract:

To develop and acquire the basic and necessary software and hardware required for the MRI research at HKU.

 

Project Title:

Manganese-enhanced Magnetic Resonance Imaging of Rodent Brain Function and Pathology

Investigator(s):

Wu EX

Department:

Engineering Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

10/2005

 

Abstract:

Manganese ions (Mn++) have been recently discovered as a Ca++ analog in neuronal transport that tracks various active neuronal pathways and cortical projections. The primary objective of this project is to explore and develop in vivo Mn-enhanced MRI (MEMRI) technology that is suitable for interrogation of rodent brain functions in normal and pathological states. The specific aims are to (1) establish an optimal high-resolution MEMRI protocol to detect neural activity in various regions of normal rodent brain; (2) define and characterize altered patterns of MEMRI enhancement associated with neonatal hypoxia ischemia in mouse model and glaucoma in rat model.

 

Project Title:

MRI of gas-filled microbubbles for microbubble-based therapeutic applications

Investigator(s):

Wu EX, Xu B, Khong PL

Department:

Engineering Faculty

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

09/2006

 

Abstract:

To characterize MRI sensitivity in detecting gas-filled microbubbles; to evaluate the ability of MRI to monitor microbubble cavitation procedure in real time; to explore and evaluate a new gas-filled microbubble design that has enhanced MRI detectability.

 

Project Title:

Magnetic Resonance Measurement of Heart and Liver Iron

Investigator(s):

Wu EX

Department:

Electrical & Electronic Engg

Source(s) of Funding:

The National Institute of Diabetes and Digestive and Kidney Diseases

Start Date:

11/2006

 

Abstract:

1. Implementation and optimization of projection-reconstruction, gradient- and spin-echo imaging sequences to map T2 and T2* in test phantoms. The work initially will be performed at 7 Tesla for testing and then implemented for clinical imaging at 3 Tesla. This component of the research work will also include development of necessary software toolkits for image data analysis. 2.Optimization of clinical protocols at 3 Tesla for T2 and T2* measurements using projection-reconstruction, gradient- and spin-echo sequences in the anterior pituitary, pancreas and gonads. 3. Estimates of iron deposition in the anterior pituitary, pancreas and gonads using the optimized MRI protocols will be compared with the results of clinical evaluation of endocrine function in a group of thalassaemia patients with a wide range of body iron burdens.

 

Project Title:

Cell labeling for In Vivo MRI Monitoring after Transplantation in Cell Based Therapies

Investigator(s):

Wu EX

Department:

Engineering Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

01/2007

 

Abstract:

In vivo monitoring of stem cells after grafting is essential for a better understanding of their migrational dynamics and differentiation processes and of their therapeutic potential. High-field magnetic resonance imaging (MRI) is potentially capable of tracking transplanted stem cells, and characterizing resulting anatomical, physiological and functional recovery in vivo, intact, and with high spatial resolution. We propose to develop such cellular imaging methodology on a 7 Tesla MRI scanner by (i) designing various techniques to label cells in vitro and quantitatively monitoring their in vivo distribution and activity after transplantation in stem cell therapy in rat stroke model; (ii) characterizing the therapeutic outcome in terms of anatomical structures and physiological functions using various MRI methods.

 

List of Research Outputs

 

Cheung S.C., Chow M.K.A., Hui S.K., Yang J., Tse H.F. and Wu E.X., Cell number quantification of USPIO-labeled stem cells by MRI: an in vitro study., 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS). 2006, 476.

 

Researcher : Yiu MWC

List of Research Outputs

 

Wong R.W.M., Lai K.C., Yiu M.W.C., Wong B.C.Y., Chan F.L. and Lai C.L., Intestinal tuberculosis mimicking fistulizing Crohn's disease, Journal of Gastroenterology and Hepatology. 2007, 22: 137-139.

 

Researcher : Yuen JHF

List of Research Outputs

 

Chok K.S.H., Ng K.K.C., Poon R.T.P., Lam C.M., Yuen J.H.F., Tso W.K. and Fan S.T., Comparable survival in patients with unresectable hepatocellular carcinoma treated by radiofrequency ablation or transarterial chemoembolization, Archives of Surgery. 2006, 141(12): 1231-1236.

 

Chow D.H.F., Sinn L.H.Y., Ng K.K.C., Lam C.M., Yuen J.H.F., Fan S.T. and Poon R.T.P., Radiofrequency ablation for hepatocellular carcinoma and metastatic liver tumors: a comprative study, Journal of Surgical Oncology. 2006, 94(7): 565-571.

 

Ng K.K.C., Poon R.T.P., Lo C.M., Yuen J.H.F., Tso W.K. and Fan S.T., Analysis of recurrence pattern and its influence on survival outcome after radiofrequency ablation of hepatocellular carcinoma (Grassi Prize Finalist Presentation), The 20th World Congress of the International Society for Digestive Surgery 2006, Rome, Italy, 29 November - 2 December 2006. 2006.

 

Ng K.K.C., Poon R.T.P., Lo C.M., Yuen J.H.F., Tso W.K. and Fan S.T., Analysis of recurrence pattern and survival outcome after radiofrequency ablation of hepatocellular carcinoma: a single institution experience (Abstract), Surgical Practice. 2006, 10: A1.

 

Poon R.T.P., Lau C.P.Y., Pang R.W.C., Ng K.K.C., Yuen J.H.F. and Fan S.T., High serum vascular endothelial growth factor levels predict poor prognosis after radiofrequency ablation of hepatocellular carcinoma: importance of tumor biomarker in ablative therapies, Annals of Surgical Oncology. 2007, 14(6): 1835-1845.



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