DEPT OF ANAESTHESIOLOGY



Researcher : Cheung CW
Project Title:A comparison of conscious sedation with midazolam and dexmedetomidine during dental surgery under local anaesthesia.
Investigator(s):Cheung CW
Department:Anaesthesiology
Source(s) of Funding:Small Project Funding
Start Date:08/2006
Abstract:
To compare conscious sedation between midazolam and dexmedetomidine. We aim to evaluate the efficacy, dosage, side effects and acceptability of dexmedetomidine by patients and surgeons for wisdom tooth surgery under local anaesthesia. Please refer to "Aims of study" in accompanying document for details also.


List of Research Outputs

Cheung C.W., Ying C.L.A., Chiu W.K., Wong G.T.C. and Irwin M.G., A comparasion of intravenous sedation iwth Dexmedetomidine and Midazolam for Unilateral Third Molar Extraction under local anaesthesia, Anaesthesia. 2007, 62(11): 1132-1138.
Cheung C.W., Ying C.L.A., Lee L.H.Y., Tsang S.F., Tsui S.L. and Irwin M.G., An aduit of postoperative intravenous patientcontrolled analgesia with morphine: improvement over the last decade, New Zealand Anaesthesia ASM 2007.
Cheung C.W., Chairman and Speaker, Nursing Seminar, Annual Scientific Metting 2007. 2007.
Cheung C.W., Chairman, Free Paper Session. Annual Scientific Meeting in Anaesthesiology. . HK, 2007.
Cheung C.W., Evolution of Acute Pain Service: Real Improvement?, Chinese Association for the Study of Pain, 2008 Annual Meeting and Scientific Conference, Taiwan. 2008.
Cheung C.W., Peer Reviewer, European Neuropscychopharmacology. 2008. 2008.
Cheung C.W., Seapker, Evolution of Acute Pai Service: Real Improvement? , Chinese Associate for the STudy of Pain, 2008 Annual Meeting and Scientific Conference. 29-30 March . 2008.
Cheung C.W., Vocational Training of Anesthesiology in Hong Kong, Asia-Pacific Inhalational Anesthesia Symposium. West China Hospital ChengDu, China.. 2007.


Researcher : Huang Z
List of Research Outputs

Xia Z., Wang F., Liu H.M., Xia Z.Y., Irwin M.G., Huang Z. and Ouyang J., PKC-beta2 activtion plays a major role in TNF-alpha-induced human vascular endothelial cell apoptosis, The IXth World Conference on Clinical Pharmacology and Therapeutics. Canada, 2007.


Researcher : Hui TWC
List of Research Outputs

Yuen V.M.Y., Hui T.W.C., Irwin M.G. and Yuen M.K., A comparison of intranasal dexmedetomidine and oral midazolam for premedication in pediatric anesthesia: a double-blinded randomized controlled trial, Anesthesia & Analgesia. 2008, 106: 1715-1721.
Yuen V.M.Y., Irwin M.G., Hui T.W.C., Yuen M.K. and Lee L.H.Y., A double blind crossover assessment of the sedative and analgesic effects of intranasal dexmedetomidine, Anaesthesia & Analgesia. USA, 2007, 105 (2): 374-380.


Researcher : Irwin MG
List of Research Outputs

Chan Y.C., Cheng S.W.K. and Irwin M.G., Perioperative use of statins in noncardiac surgery, Vascular Health and Risk Management . 2008, 4(1): 75-81.
Cheung C.W., Ying C.L.A., Chiu W.K., Wong G.T.C. and Irwin M.G., A comparasion of intravenous sedation iwth Dexmedetomidine and Midazolam for Unilateral Third Molar Extraction under local anaesthesia, Anaesthesia. 2007, 62(11): 1132-1138.
Cheung C.W., Ying C.L.A., Lee L.H.Y., Tsang S.F., Tsui S.L. and Irwin M.G., An aduit of postoperative intravenous patientcontrolled analgesia with morphine: improvement over the last decade, New Zealand Anaesthesia ASM 2007.
Choi W.S., Irwin M.G. and Samman N., The effect of tranexamic acid on blood loss during orthognathic surgery: a randomized controlled trial, Inaugural Conjoint Dental Scientific Meeting, The University of Hong Kong and Wuhan University. 10-11 May, 2008, China. 2008, p. 41.
Diemunsch P., Gan T.J., Philip B., Girao M., Eberhart L., Irwin M.G., Pueyo J. and Lawson F.C., Single-dose aprepitant versus ondansetron for the prevention of postoperative nausea and vomiting: a randomized, double-blind Phase III trial in patients undergoing open abdominal surgery, British Journal of Anaesthesia. UK, 2007, 99 (2): 202-211.
Guo C.X., Irwin M.G., Cheung K.M.C. and Chan D., An effective dose of Valdecoxib in experimental mouse models of pain, Methods Find Exp Clin Pharmacol. 2007, 29(6): 383-388.
Irwin M.G., 59. Inhalation v intravenous anaesthesia; Depth of anaesthesia monitoring; Fluid management in gastrointestinal surgery. 3 invited lectures., FRACTA Sydney Australia. 2008.
Irwin M.G., Alpha-2 agonists in anaesthesia., ASEAN Anaesthesia. Bangkok . 2007.
Irwin M.G., Anaesthesia for endovascular surgery; Remifentanil and cardiac preconditioning. 2 invited lectures. , HKCA Annual Scientific Meeting in Anaesthesiology, Hong Kong, . 2007.
Irwin M.G., Antiplatelet agents and surgery, Shenzhen Anesthesiology Annual Meeting. China, 2008.
Irwin M.G., Dexmedetomidine in pain management, 2nd Congress of the Association of South East Asian Pain Societies, Kuala Lumpur. Malaysia, 2007.
Irwin M.G., Editor, Acta Anesthesia Taiwanica. 2008. 2008.
Irwin M.G., Editor, Acute Pain. 2008. 2008.
Irwin M.G., Editor, CPD Anaesthesia. 2008. 2008.
Irwin M.G., Editor, Hong Kong Medical Journal. 2008.
Irwin M.G., Expert panel member "Cardiovascular medicine in anesthesia: basic science" , Faculty of 1000 Medicine. 2008.
Irwin M.G., Intravenous anaesthesia and TCI. 2 invited lectures., Vietnam Society of Anaesthetists.. 2008.
Irwin M.G., Invited reviewer, Asean Journal of Anaesthesiology. 2008. Malaysia, 2008.
Irwin M.G., Invited to join Faculty of 1000 Medicine panel as an expert in cardiovascular medicine in anaesthesia. I contribute one article every 1 to 2 months, In: see URL, Faculty of 1000 Medicine http://www.f1000medicine.com/my/. 2008.
Irwin M.G., NSAIDs – myths and realities , Malaysian Society of Anaesthesiology ASM . 2008.
Irwin M.G., Neurokinin antagonists; Remifentanil cardioprotection; NSAIDs; Alpha-2 agonist drugs; Opioid pharmacogenetics; Safe sedation. 6 invited lectures., 1st World Congress of Intravenous Anaesthesia. Italy . 2007.
Irwin M.G., Opioid cardiac preconditioning, Shenzhen anesthesiology Annual Meeting. China, 2008.
Irwin M.G., Opioid pharmacogenetics, 2nd Congress of the Association of South East Asian Pain Societies, Kuala Lumpur. Malaysia, 2007.
Irwin M.G., Opioid pharmacogenetics, Glasgow University Symposium on Anaesthesia (retiral of Prof GNC Kenny). Scotland . 2007.
Irwin M.G., Peer Reviewer, Anesthesiology 2008. 2008.
Irwin M.G., Peer Reviewer, Asean Journal of Anaesthesiology. 2008. 2008.
Irwin M.G., Peer Reviewer, British Journal of Anaesthesia. 2008. 2008.
Irwin M.G., Peer Reviewer, Canadian Journal of Anaesthesia. 2008. 2008.
Irwin M.G., Peer Reviewer, Hong Kong Medical Journal. 2008. 2008.
Irwin M.G., Peer Reviewer, Journal of Clinical anaesthesia. 2008. 2008.
Irwin M.G., Peer Reviewer, Journal of clinical Anaesthesia. 2008. 2008.
Irwin M.G., Peer Reviewer, Medical Science Monitor. 2008. 2008.
Irwin M.G., Perioperative cardioprotection. , New Zealand Society of Anaesthetists ASM. 2007.
Irwin M.G., Referee, CERG (RGC). 2008. 2008.
Irwin M.G., Referee, Health Services Research Committee/Health Care & Promotion Fund Committee. 2008. 2008.
Irwin M.G., Remifentanil combinations with propofol., Asian Anaesthesia Innovators Meeting. Tokyo . 2007.
Irwin M.G., Remifentanil preconditioning, Shanghai Society of Anaesthetists Annual Scientific Meeting. China, 2008.
Irwin M.G., Senior Editor, Hong Kong Medical Journal. 2008. 2008.
Irwin M.G., Target controlled infusion; Fluid management in critical care. 2 invited lectures, Singapore/Duke University Conjoint Scientific Meeting. . 2008.
Kong V.K.F. and Irwin M.G., Gabapentin: a multimodal perioperative drug? , British Journal of Anaesthesia. UK, 2007.
Kong V.K.F., Yuen M.K. and Irwin M.G., Perioperative Ultrasonography: ultrasound and vascular cannulation, CPD Anaesthesia. 2007, 1: 3-9.
Li R., Wong G.T.C., Wong T.M., Zhang Y. and Irwin M.G., Intrathecal Morphine preconditions the heart via kappa, delta and mu opioid receptors, World Congress of Anaesthesiology, Cape Town. 2008.
Li Y., Yu C.K., Wong G.T.C., Wong T.M. and Irwin M.G., Remifentanil preconditioning confers delayed cardioprotection in the rat, British Journal of Anaesthesia. UK, 2007, 99: 632 - 638.
Wong G.L.S., Yong B.H., Young K.K., Lau L.S., Cheng K.L., Man J.S.F. and Irwin M.G., Comparison of the USCOM ultrasound cardiac output monitor with pulmonary artery catheter thermodilution in patients undergoing liver transplantation, Liver Transplantation. 2008, 14: 1038-1043.
Wong G.T.C., Jenkins C.R., Yao T. and Irwin M.G., A Trend Toward Improved Learning of Cardiovascular Pathophysiology in Medical Students From Using a Human Patient Simulator: Results of a Pilot Study, Advances in Physiology Education. 2007, 31: 372.
Wong G.T.C. and Irwin M.G., Contrast induced nephropathy, British Journal of Anaesthesia. 2007, 99: 474-483.
Wong G.T.C., Li R. and Irwin M.G., Remifentanil Postconditioning Attenuates Cardiac Ischaemia-Reperfusion Injury in vivo, Annual Scientific Meeting, Australian and New Zealand College of Anaesthetists. 2008.
Xia Z., Wang F., Liu H.M., Xia Z.Y., Irwin M.G., Huang Z. and Ouyang J., PKC-beta2 activtion plays a major role in TNF-alpha-induced human vascular endothelial cell apoptosis, The IXth World Conference on Clinical Pharmacology and Therapeutics. Canada, 2007.
Yao C.L., Trinh T.P., Wong G.T.C. and Irwin M.G., Anaesthesia for high intensity focused ultrasound (HIFU) therapy, Anaesthesia. 2008, 63: 865-872.
Yuen V.M.Y., Hui T.W.C., Irwin M.G. and Yuen M.K., A comparison of intranasal dexmedetomidine and oral midazolam for premedication in pediatric anesthesia: a double-blinded randomized controlled trial, Anesthesia & Analgesia. 2008, 106: 1715-1721.
Yuen V.M.Y., Irwin M.G., Hui T.W.C., Yuen M.K. and Lee L.H.Y., A double blind crossover assessment of the sedative and analgesic effects of intranasal dexmedetomidine, Anaesthesia & Analgesia. USA, 2007, 105 (2): 374-380.


Researcher : Jenkins CR
List of Research Outputs

Wong G.T.C., Jenkins C.R., Yao T. and Irwin M.G., A Trend Toward Improved Learning of Cardiovascular Pathophysiology in Medical Students From Using a Human Patient Simulator: Results of a Pilot Study, Advances in Physiology Education. 2007, 31: 372.


Researcher : Kong VKF
List of Research Outputs

Kong V.K.F. and Irwin M.G., Gabapentin: a multimodal perioperative drug? , British Journal of Anaesthesia. UK, 2007.
Kong V.K.F., Yuen M.K. and Irwin M.G., Perioperative Ultrasonography: ultrasound and vascular cannulation, CPD Anaesthesia. 2007, 1: 3-9.


Researcher : Lee LHY
List of Research Outputs

Cheung C.W., Ying C.L.A., Lee L.H.Y., Tsang S.F., Tsui S.L. and Irwin M.G., An aduit of postoperative intravenous patientcontrolled analgesia with morphine: improvement over the last decade, New Zealand Anaesthesia ASM 2007.
Yuen V.M.Y., Irwin M.G., Hui T.W.C., Yuen M.K. and Lee L.H.Y., A double blind crossover assessment of the sedative and analgesic effects of intranasal dexmedetomidine, Anaesthesia & Analgesia. USA, 2007, 105 (2): 374-380.


Researcher : Li CF
List of Research Outputs

Ng J.K.F., Lawmin J.C., Li C.F., Tsang S.F., Tang W.M. and Chiu P.K.Y., Comprehensive evaluation of platelet dysfunction in patients taking diclofenac before joint arthroplasties, Journal of Arthroplasty. 2008, 23: 424-430.


Researcher : Li R
List of Research Outputs

Li R., Wong G.T.C., Wong T.M., Zhang Y. and Irwin M.G., Intrathecal Morphine preconditions the heart via kappa, delta and mu opioid receptors, World Congress of Anaesthesiology, Cape Town. 2008.
Wong G.T.C., Li R. and Irwin M.G., Remifentanil Postconditioning Attenuates Cardiac Ischaemia-Reperfusion Injury in vivo, Annual Scientific Meeting, Australian and New Zealand College of Anaesthetists. 2008.


Researcher : Li Y
List of Research Outputs

Li Y., Yu C.K., Wong G.T.C., Wong T.M. and Irwin M.G., Remifentanil preconditioning confers delayed cardioprotection in the rat, British Journal of Anaesthesia. UK, 2007, 99: 632 - 638.


Researcher : Liu H
List of Research Outputs

Xia Z., Luo T., Liu H., Wang F., Ouyang J., Xia Z.Y., Yang X.C. and Fan Q., L-arginine Compromises Propofol Protection of The Endothelium Against TNF-alpha induced apoptotic cell death. Anesth Analg 2008:SCA45., Anesthesia & Analgesia. 2008, 106(SCA Supple): 45.


Researcher : Man JSF
List of Research Outputs

Wong G.L.S., Yong B.H., Young K.K., Lau L.S., Cheng K.L., Man J.S.F. and Irwin M.G., Comparison of the USCOM ultrasound cardiac output monitor with pulmonary artery catheter thermodilution in patients undergoing liver transplantation, Liver Transplantation. 2008, 14: 1038-1043.


Researcher : Ng JKF
Project Title:Thrombelastographic profile in elderlies
Investigator(s):
Department:Anaesthesiology
Source(s) of Funding:Other Funding Scheme
Start Date:06/1999
Abstract:
To compare thrombelastrographic profile of healthy elderlies to healthy young adults.


Project Title:Effect of non-steroidal anti-inflammatory agents on platelet function and blood loss in patients undergoing knee replacement surgery
Investigator(s):Ng JKF, Lam CCK, Tang WM
Department:Anaesthesiology
Source(s) of Funding:Low Budget High Impact Programme
Start Date:11/2001
Abstract:
To evaluate a new platelet function analyser (PFA)-100TM) as a preoperative platelet function monitor.


Project Title:In vitro effect of desmopressin on hypothermia induced platelet dysfunction
Investigator(s):Ng JKF
Department:Anaesthesiology
Source(s) of Funding:Small Project Funding
Start Date:08/2006
Abstract:
Mild hypothermia (32 to 35 degC) during surgery is common [1] and is associated with more bleeding, increased transfusion requirement and poorer outcome [2-4]. While inhibition of the coagulation cascade is known to occur with hypothermia [5] and may contribute to these changes, hypothermia also induces platelet dysfunction which can accentuate this problem. The underlying mechanism of hypothermia-induced platelet dysfunction remains poorly understood. In vitro studies showed impaired platelet aggregation and adhesion under mild hypothermia [6]. Moreover, shed blood thromboxane A2 from bleeding time wound is diminished and the rise in p-selectin expression on platelet surface is obtunded [7,8]. Nevertheless, there are also some conflicting results showing that hypothermia may lead to enhanced platelet activation [9,10]. Such platelet dysfunction is reversible when normal body temperature is restored [11,12], but this is not always achievable or desirable. Hypothermia occurs in 5 to 10% of multiple trauma patients at admission [13,14]. It may not be rapidly reversible, particularly in those who require massive infusion of fluids and blood products. The incidence of hypothermia actually increases to over 70% when the trauma patients receive emergency surgery [15]. Restoration of normothermia may not be desirable in some patients as induced hypothermia has been shown to improve patient outcome after successful cardiopulmonary resuscitation [16] and has become the recommended treatment in selected patients [17]. Induced hypothermia is also useful in the intensive care unit [18] and in neurosurgery [19]. Desmopressin (1-deamino-8-D-arginine vasopressin, DDAVP), the synthetic analogue of vasopressin, was first used to treat cranial diabetes insipidus. Later, it was found that desmopressin elevates circulating coagulation factor (F)VIII, von Willebrand factor (vWF) and tissue plasminogen activator (tPA) in patients who suffer from hemophilia A and von Willebrand disease [20]. Since then, it remains the treatment of choice for these congenital bleeding disorders [21]. Desmopressin can also correct certain acquired bleeding disorders, such as patients with uremia and liver cirrhosis [22,23]. However, the effect of desmopressin on platelet dysfunction due to hypothermia is still unknown. We have therefore designed this study to investigate the effects of different doses of desmopressin on hypothermia-induced platelet dysfunction. Platelet function will be measured by the PFA-100® system, which is a relatively new technique that simulates primary hemostasis using whole blood [24,25]. 1 Sessler DI. Mild perioperative hypothermia. N Engl J Med 1997; 336: 1730-7. 2 Hofer CK, Worn M, Tavakoli R, Sander L, Maloigne M, Klaghofer R, Zollinger A. Influence of body core temperature on blood loss and transfusion requirements during off-pump coronary artery bypass grafting: a comparison of 3 warming systems. J Thorac Cardiovasc Surg 2005; 129: 838-43. 3 Kurz A, Sessler DI, Lenhardt R. Perioperative normothermia to reduce the incidence of surgical-wound infection and shorten hospitalization. Study of Wound Infection and Temperature Group. N Engl J Med 1996; 334: 1209-15. 4 Schmied H, Kurz A, Sessler DI, Kozek S, Reiter A. Mild hypothermia increases blood loss and transfusion requirements during total hip arthroplasty. Lancet 1996; 347: 289-92. 5 Boldt J, Knothe C, Welters I, Dapper FL, Hempelmann G. Normothermic versus hypothermic cardiopulmonary bypass: do changes in coagulation differ? Ann Thorac Surg 1996; 62: 130-5. 6 Wolberg AS, Meng ZH, Monroe DM, 3rd, Hoffman M. A systematic evaluation of the effect of temperature on coagulation enzyme activity and platelet function. J Trauma 2004; 56: 1221-8. 7 Michelson AD, Barnard MR, Khuri SF, Rohrer MJ, MacGregor H, Valeri CR. The effects of aspirin and hypothermia on platelet function in vivo. Br J Haematol 1999; 104: 64-8. 8 Valeri CR, MacGregor H, Cassidy G, Tinney R, Pompei F. Effects of temperature on bleeding time and clotting time in normal male and female volunteers. Crit Care Med 1995; 23: 698-704. 9 Faraday N, Rosenfeld BA. In vitro hypothermia enhances platelet GPIIb-IIIa activation and P-selectin expression. Anesthesiology 1998; 88: 1579-85. 10 Zhang JN, Wood J, Bergeron AL, McBride L, Ball C, Yu Q, Pusiteri AE, Holcomb JB, Dong JF. Effects of low temperature on shear-induced platelet aggregation and activation. J Trauma 2004; 57: 216-23. 11 Michelson AD, MacGregor H, Barnard MR, Kestin AS, Rohrer MJ, Valeri CR. Reversible inhibition of human platelet activation by hypothermia in vivo and in vitro. Thromb Haemost 1994; 71: 633-40. 12 Valeri CR, Feingold H, Cassidy G, Ragno G, Khuri S, Altschule MD. Hypothermia-induced reversible platelet dysfunction. Ann Surg 1987; 205: 175-81. 13 Shafi S, Elliott AC, Gentilello L. Is hypothermia simply a marker of shock and injury severity or an independent risk factor for mortality in trauma patients? Analysis of a large national trauma registry. J Trauma 2005; 59: 1081-5. 14 Wang HE, Callaway CW, Peitzman AB, Tisherman SA. Admission hypothermia and outcome after major trauma. Crit Care Med 2005; 33: 1296-301. 15 Gregory JS, Flancbaum L, Townsend MC, Cloutier CT, Jonasson O. Incidence and timing of hypothermia in trauma patients undergoing operations. J Trauma 1991; 31: 795-8; discussion 798-800. 16 The Hypothermia after Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med 2002; 346: 549-56. 17 Nolan JP, Morley PT, Vanden Hoek TL, Hickey RW, Kloeck WG, Billi J, Bottiger BW, Morley PT, Nolan JP, Okada K, Reyes C, Shuster M, Steen PA, Weil MH, Wenzel V, Hickey RW, Carli P, Vanden Hoek TL, Atkins D. Therapeutic hypothermia after cardiac arrest: an advisory statement by the advanced life support task force of the International Liaison Committee on Resuscitation. Circulation 2003; 108: 118-21. 18 Polderman KH. Application of therapeutic hypothermia in the ICU: opportunities and pitfalls of a promising treatment modality. Part 1: Indications and evidence. Intensive Care Med 2004; 30: 556-75. 19 Kouchoukos NT, Daily BB, Wareing TH, Murphy SF. Hypothermic circulatory arrest for cerebral protection during combined carotid and cardiac surgery in patients with bilateral carotid artery disease. Ann Surg 1994; 219: 699-705; discussion 705-6. 20 Mannucci PM, Ruggeri ZM, Pareti FI, Capitanio A. 1-Deamino-8-d-arginine vasopressin: a new pharmacological approach to the management of haemophilia and von Willebrands' diseases. Lancet 1977; 309: 869-72. 21 Mannucci PM. Desmopressin (DDAVP) in the treatment of bleeding disorders: the first 20 years. Blood 1997; 90: 2515-21. 22 Mannucci PM, Vicente V, Vianello L, Cattaneo M, Alberca I, Coccato MP, Faioni E, Mari D. Controlled trial of desmopressin in liver cirrhosis and other conditions associated with a prolonged bleeding time. Blood 1986; 67: 1148-53. 23 Mannucci PM, Remuzzi G, Pusineri F, Lombardi R, Valsecchi C, Mecca G, Zimmerman TS. Deamino-8-D-arginine vasopressin shortens the bleeding time in uremia. N Engl J Med 1983; 308: 8-12. 24 Mammen EF, Alshameeri RS, Comp PC. Preliminary data from a field trial of the PFA-100 system. Semin Thromb Hemost 1995; 21 Suppl 2: 113-21. 25 Kundu SK, Heilmann EJ, Sio R, Garcia C, Davidson RM, Ostgaard RA. Description of an in vitro platelet function analyzer--PFA-100. Semin Thromb Hemost 1995; 21 Suppl 2: 106-12.


List of Research Outputs

Ho Y.W., Leung G.P.H., Man R.Y.K., Vanhoutte P.M.G.R. and Ng J.K.F., Distributions of alpha 2 adrenoceptor subtypes in porcine coronary vasculature, Experimental Biology 2008, San Diego. 2008.
Ng J.K.F., Complex Regional Pain Syndrome, Hong Kong Pain Society Annual Scientific Meeting 2007. 2007.
Ng J.K.F., Lawmin J.C., Li C.F., Tsang S.F., Tang W.M. and Chiu P.K.Y., Comprehensive evaluation of platelet dysfunction in patients taking diclofenac before joint arthroplasties, Journal of Arthroplasty. 2008, 23: 424-430.
Ng J.K.F., Lawmin J.C., Li C.C.F., Tsang S.F., Tang W.M. and Chiu P.K.Y., Comprehensive preoperative evaluation of platelet function in total knee arthroplasty patients taking diclofenac., J Arthroplasty. 2008, 23: 424-30.
Ng J.K.F., Desmopressin and Hypothermia-induced Platelet Dysfunction, Shanghai-Taiwan-Hongkong-Singapore Anaesthesiology Symposium. 2007.
Ng J.K.F., Dexmedetomidine - a Coronary Vasoconstrictor?, ASM 2007 HK College of Anaesthesiologists. 2007.
Ng J.K.F., Dexmedetomidine - a coronary vasoconstrictor?, ASM 2007 HK College of Anaesthesiologists. 2007.
Ng J.K.F., Lawmin J.C., Tsang S.F., Tang W.M. and Chiu P.K.Y., PFA-100 closure times and blood loss during total knee arthroplasty in patients taking NSAIDs, HAA 2007 Combined Annual Scientific Meeting of the Haematology Society of Australia & New Zealand, the Australian & New Zealand Society of Blood Transfusion, and the Australasian Society of Thrombosis & Haemostasis. 2007.
Ng J.K.F., Lawmin J.C., Tsang S.F., Tang W.M. and Chiu P.K.Y., PFA-100 closure times and postoperative blood loss after total knee arthroplasty in patients taking NSAIDs, XXIst International Symposium on Technological Innovations in Laboratory Hematology, Sydney Convention Centre, Sydney, Australia, April 28 - May 1, 2008.
Ng J.K.F., Lawmin J.C., Tsang S.F., Tang W.M. and Chiu P.K.Y., PFA-100 closure times and postoperative blood loss after total knee arthroplasty in patients taking NSAIDs, Int J Lab Hematol 2008. 30 Suppl1: 103 A419.
Ng W.W.H., Keung W.W.Y., Xu Y., Ng J.K.F., Leung G.P.H., Vanhoutte P.M.G.R., Choy P.C. and Man R.Y.K., Genistein potentiates protein kinase A activity in porcine coronary artery, Molecular and Cellular Biochemistry. 2008, 311: 37-44.
Ying C.L.A., Tsang S.F. and Ng J.K.F., Potential use of desmopressin to correct hypothermia-induced impairment of primary haemostasis - an in vitro study using PFA-100, Resuscitation. 2008, 76: 129-33.


Researcher : Trinh TP
List of Research Outputs

Yao C.L., Trinh T.P., Wong G.T.C. and Irwin M.G., Anaesthesia for high intensity focused ultrasound (HIFU) therapy, Anaesthesia. 2008, 63: 865-872.


Researcher : Tsang SF
List of Research Outputs

Cheung C.W., Ying C.L.A., Lee L.H.Y., Tsang S.F., Tsui S.L. and Irwin M.G., An aduit of postoperative intravenous patientcontrolled analgesia with morphine: improvement over the last decade, New Zealand Anaesthesia ASM 2007.
Ng J.K.F., Lawmin J.C., Li C.F., Tsang S.F., Tang W.M. and Chiu P.K.Y., Comprehensive evaluation of platelet dysfunction in patients taking diclofenac before joint arthroplasties, Journal of Arthroplasty. 2008, 23: 424-430.
Ng J.K.F., Lawmin J.C., Li C.C.F., Tsang S.F., Tang W.M. and Chiu P.K.Y., Comprehensive preoperative evaluation of platelet function in total knee arthroplasty patients taking diclofenac., J Arthroplasty. 2008, 23: 424-30.
Ng J.K.F., Lawmin J.C., Tsang S.F., Tang W.M. and Chiu P.K.Y., PFA-100 closure times and blood loss during total knee arthroplasty in patients taking NSAIDs, HAA 2007 Combined Annual Scientific Meeting of the Haematology Society of Australia & New Zealand, the Australian & New Zealand Society of Blood Transfusion, and the Australasian Society of Thrombosis & Haemostasis. 2007.
Ng J.K.F., Lawmin J.C., Tsang S.F., Tang W.M. and Chiu P.K.Y., PFA-100 closure times and postoperative blood loss after total knee arthroplasty in patients taking NSAIDs, XXIst International Symposium on Technological Innovations in Laboratory Hematology, Sydney Convention Centre, Sydney, Australia, April 28 - May 1, 2008.
Ng J.K.F., Lawmin J.C., Tsang S.F., Tang W.M. and Chiu P.K.Y., PFA-100 closure times and postoperative blood loss after total knee arthroplasty in patients taking NSAIDs, Int J Lab Hematol 2008. 30 Suppl1: 103 A419.
Ying C.L.A., Tsang S.F. and Ng J.K.F., Potential use of desmopressin to correct hypothermia-induced impairment of primary haemostasis - an in vitro study using PFA-100, Resuscitation. 2008, 76: 129-33.


Researcher : Tsui SL
List of Research Outputs

Cheung C.W., Ying C.L.A., Lee L.H.Y., Tsang S.F., Tsui S.L. and Irwin M.G., An aduit of postoperative intravenous patientcontrolled analgesia with morphine: improvement over the last decade, New Zealand Anaesthesia ASM 2007.


Researcher : Wong GLS
List of Research Outputs

Wong G.L.S., Yong B.H., Young K.K., Lau L.S., Cheng K.L., Man J.S.F. and Irwin M.G., Comparison of the USCOM ultrasound cardiac output monitor with pulmonary artery catheter thermodilution in patients undergoing liver transplantation, Liver Transplantation. 2008, 14: 1038-1043.


Researcher : Wong GTC
List of Research Outputs

Cheung C.W., Ying C.L.A., Chiu W.K., Wong G.T.C. and Irwin M.G., A comparasion of intravenous sedation iwth Dexmedetomidine and Midazolam for Unilateral Third Molar Extraction under local anaesthesia, Anaesthesia. 2007, 62(11): 1132-1138.
Li R., Wong G.T.C., Wong T.M., Zhang Y. and Irwin M.G., Intrathecal Morphine preconditions the heart via kappa, delta and mu opioid receptors, World Congress of Anaesthesiology, Cape Town. 2008.
Li Y., Yu C.K., Wong G.T.C., Wong T.M. and Irwin M.G., Remifentanil preconditioning confers delayed cardioprotection in the rat, British Journal of Anaesthesia. UK, 2007, 99: 632 - 638.
Wong G.T.C., Jenkins C.R., Yao T. and Irwin M.G., A Trend Toward Improved Learning of Cardiovascular Pathophysiology in Medical Students From Using a Human Patient Simulator: Results of a Pilot Study, Advances in Physiology Education. 2007, 31: 372.
Wong G.T.C. and Irwin M.G., Contrast induced nephropathy, British Journal of Anaesthesia. 2007, 99: 474-483.
Wong G.T.C., Li R. and Irwin M.G., Remifentanil Postconditioning Attenuates Cardiac Ischaemia-Reperfusion Injury in vivo, Annual Scientific Meeting, Australian and New Zealand College of Anaesthetists. 2008.
Wong G.T.C., The Use of Simulation in Medical Education, West China Anesthesiology Conference. 2007.
Yao C.L., Trinh T.P., Wong G.T.C. and Irwin M.G., Anaesthesia for high intensity focused ultrasound (HIFU) therapy, Anaesthesia. 2008, 63: 865-872.


Researcher : Xia Z
List of Research Outputs

Nie R., Zhong X. and Xia Z., Antioxidant intervention before and during myocardial ischemia may exacerbate post-ischemic myocardial dysfunction: relationship with endothelin-1 production, Medical Hypotheses. 2008, 70(1): 194-5.
Nie R., Xia R., Zhong X. and Xia Z., Salvia Miltiorrhiza Treatment During Early Reperfusion Reduced Post-Ischemic Myocardial Injury In The Rat, Canadian Journal of Physiology and Pharmacology. 2007, 85: 85(10):1012-9.
Xia Z., External Grant Reviewer, Canadian Institute of Health Research. 2007.
Xia Z., Luo T., Liu H., Wang F., Ouyang J., Xia Z.Y., Yang X.C. and Fan Q., L-arginine Compromises Propofol Protection of The Endothelium Against TNF-alpha induced apoptotic cell death. Anesth Analg 2008:SCA45., Anesthesia & Analgesia. 2008, 106(SCA Supple): 45.
Xia Z., Wang F., Liu H.M., Xia Z.Y., Irwin M.G., Huang Z. and Ouyang J., PKC-beta2 activtion plays a major role in TNF-alpha-induced human vascular endothelial cell apoptosis, The IXth World Conference on Clinical Pharmacology and Therapeutics. Canada, 2007.
Xia Z., Peer Reviewer, Anesthesiology. 2008.
Xia Z., Peer Reviewer, Applied Physiology, Nutrition, and Metabolism. 2008.
Xia Z., Peer Reviewer, BMC Anesthesiology. 2007.
Xia Z., Peer Reviewer, Clinical Journal of Anesthesia. 2008.
Xia Z., Peer Reviewer, Cytotherapy. 2007.
Xia Z., Peer Reviewer, European Jounral of Pharmacology. 2008.
Xia Z., Peer Reviewer, Journal of Food Biochemistry. 2008.
Xia Z., Pharmacological attenuation of myocardial ischemia-reperfusion injury, Heart Center of Beijing Chaoyang Hospital affiliated to The Capital Medical University. 2008.
Xia Z., Propofol attenuation of myocardial ischemia-reperfusion injury: from bench to bed-side, International Chinese Cardiovascular Anesthesia Forum. 2008.
Xia Z., Relative Role of superoxide and hydrogen peroxide in hyperglycemia-induced cardiomyocyte hypertrophy, Faculty of Pharmaceutical Sciences, The University of British Columbia, Canada. 2008.
Xia Z., In: Z. Xia, editoral advisory board, The Open Anesthesiology Journal. 2008.


Researcher : Yao CL
List of Research Outputs

Yao C.L., Trinh T.P., Wong G.T.C. and Irwin M.G., Anaesthesia for high intensity focused ultrasound (HIFU) therapy, Anaesthesia. 2008, 63: 865-872.


Researcher : Ying CLA
List of Research Outputs

Cheung C.W., Ying C.L.A., Chiu W.K., Wong G.T.C. and Irwin M.G., A comparasion of intravenous sedation iwth Dexmedetomidine and Midazolam for Unilateral Third Molar Extraction under local anaesthesia, Anaesthesia. 2007, 62(11): 1132-1138.
Cheung C.W., Ying C.L.A., Lee L.H.Y., Tsang S.F., Tsui S.L. and Irwin M.G., An aduit of postoperative intravenous patientcontrolled analgesia with morphine: improvement over the last decade, New Zealand Anaesthesia ASM 2007.
Ying C.L.A., Tsang S.F. and Ng J.K.F., Potential use of desmopressin to correct hypothermia-induced impairment of primary haemostasis - an in vitro study using PFA-100, Resuscitation. 2008, 76: 129-33.


Researcher : Yong BH
List of Research Outputs

Wong G.L.S., Yong B.H., Young K.K., Lau L.S., Cheng K.L., Man J.S.F. and Irwin M.G., Comparison of the USCOM ultrasound cardiac output monitor with pulmonary artery catheter thermodilution in patients undergoing liver transplantation, Liver Transplantation. 2008, 14: 1038-1043.


Researcher : Young KK
List of Research Outputs

Wong G.L.S., Yong B.H., Young K.K., Lau L.S., Cheng K.L., Man J.S.F. and Irwin M.G., Comparison of the USCOM ultrasound cardiac output monitor with pulmonary artery catheter thermodilution in patients undergoing liver transplantation, Liver Transplantation. 2008, 14: 1038-1043.


Researcher : Yu CK
List of Research Outputs

Li Y., Yu C.K., Wong G.T.C., Wong T.M. and Irwin M.G., Remifentanil preconditioning confers delayed cardioprotection in the rat, British Journal of Anaesthesia. UK, 2007, 99: 632 - 638.


Researcher : Yuen MK
List of Research Outputs

Kong V.K.F., Yuen M.K. and Irwin M.G., Perioperative Ultrasonography: ultrasound and vascular cannulation, CPD Anaesthesia. 2007, 1: 3-9.
Yuen V.M.Y., Hui T.W.C., Irwin M.G. and Yuen M.K., A comparison of intranasal dexmedetomidine and oral midazolam for premedication in pediatric anesthesia: a double-blinded randomized controlled trial, Anesthesia & Analgesia. 2008, 106: 1715-1721.
Yuen V.M.Y., Irwin M.G., Hui T.W.C., Yuen M.K. and Lee L.H.Y., A double blind crossover assessment of the sedative and analgesic effects of intranasal dexmedetomidine, Anaesthesia & Analgesia. USA, 2007, 105 (2): 374-380.


Researcher : Yuen VMY
List of Research Outputs

Yuen V.M.Y., Hui T.W.C., Irwin M.G. and Yuen M.K., A comparison of intranasal dexmedetomidine and oral midazolam for premedication in pediatric anesthesia: a double-blinded randomized controlled trial, Anesthesia & Analgesia. 2008, 106: 1715-1721.
Yuen V.M.Y., Irwin M.G., Hui T.W.C., Yuen M.K. and Lee L.H.Y., A double blind crossover assessment of the sedative and analgesic effects of intranasal dexmedetomidine, Anaesthesia & Analgesia. USA, 2007, 105 (2): 374-380.


Researcher : Zhang Y
List of Research Outputs

Li R., Wong G.T.C., Wong T.M., Zhang Y. and Irwin M.G., Intrathecal Morphine preconditions the heart via kappa, delta and mu opioid receptors, World Congress of Anaesthesiology, Cape Town. 2008.


-- End of Listing --