DEPT OF ORTHOPAEDICS AND TRAUMATOLOGY
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Researcher
: Abbah SA |
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List of Research Outputs |
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Abbah S.A., Lu W.W., Chan D., Cheung K.M.C., Zhao F., Li Z., Leong J.C.Y. and Luk K.D.K., Osteogenic behavior of alginate encapsulated bone marrow stromal cells: an in vitro study, J Mater Sci Mater Med. 2008, 19(5): 2113-9. |
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Li Z., Yang C., Lu W.W., Xu B., Lam R.W.M., Ni G., Abbah S.A., Yang F., Cheung K.M.C. and Luk K.D.K., Characteristics and mechanical properties of acrylolpamidronate-treated strontium containing bioactive bone cement, J Biomed Mater Res B Appl Biomater. 2007, 83(2): 464-71. |
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Researcher
: Ahmed SK |
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List of Research Outputs |
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Ahmed
S.K., Fung
B.K.K., Ip W.Y. and Chow S.P., Enhancing The Versatility Of
Reverse Flow Sural Artery Neurocutaneous Flap, 7th Congress of Asian
Pacific Federaton of Societies for Surgery of the Hand, |
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Ahmed S.K., Li T., Leung G., Fung B.K.K., Ip W.Y. and Chow S.P., Long Term Results Of Distal Radio Ulnar Joint Arthroplasty In Rheumatoid Patients, 7th Congress of Asian Pacific Federation of Societies for Surgery of the Hand, Hong Kong, 14-17 February 2008. |
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Ahmed S.K., Li T., Leung G., Fung B.K.K., Ip W.Y. and Chow S.P., Synovectomy Around the Wrist - Rewarding Alternate To Preserve Joint Integrity In Rheumatoid Patients, 7th Congress of Asian Pacific Federation of Societies for Surgery of the Hand, Hong Kong, 14-17 February 2008. |
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Ahmed S.K., Fung B.K.K., Ip W.Y., Fok M. and Chow S.P., The versatile reverse flow sural artery neurocutaneous flap: A case series and review of literature, Journal of Orthopaedic Surgery and Research. 2008, 3:15. |
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Ahmed S.K., Fung B.K.K., Ip W.Y. and Chow S.P., Unicompartmental Knee Hemiarthroplasty Using Vascularized Fibula Transfer - 25 Years Follow Up, 7th Congress of Asian Pacific Federation of Societies for Surgery of the Hand, Hong Kong, 14-17 February 2008 . 2008. |
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Garg R., Amer T., Ahmed S.K., Fung B.K.K., Ip W.Y. and Chow S.P., Sensate flap for bed sores: Between dream and reality: A cadaver dissection study, Journal of Orthopaedics. 2008, 5:2. |
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Li T., Leung G., Chan R., Cheung N., Ahmed S.K., Fung B.K.K., Ip W.Y. and Chow S.P., Role Of Occupational Therapist In Rehabilitation Of Rheumatoid Wrist, 7th Congress of Asian Pacific Federation of Societies for Surgery of the Hand, Hong Kong, 14-17 February 2008. |
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Researcher
: Aladin Kaderbatcha DM |
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List of Research Outputs |
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Aladin Kaderbatcha D.M., Lu W.W., Cheung K.M.C., Ngan A.H.W., Chan D. and Luk K.D.K., Association of Trp2 allele with changes in morphology and nano mechanics of the human intervertebral disc collagens, Best Basic Science Paper Award for Associate Member, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. 2007. |
|
Aladin
Kaderbatcha D.M., Lu W.W., Cheung K.M.C., Ngan A.H.K., Chan D. and Luk K.D.K., Correlation between the
Compressive Macro-mechanical Properties of the Human Nucleus Pulposus and the
Nano Structure of its Individual Collagen Fibrils, World Forum for Spine
Research - The Intervertebral Disc. |
|
Aladin
Kaderbatcha D.M., Cheung K.M.C., Chan D., Yee A.F.Y., Jim J.J.T., Luk K.D.K. and Lu W.W., Expression of the Trp2 allele
of COL |
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Researcher
: Chan CCY |
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List of Research Outputs |
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Chan C.C.Y., Chan D., Luk K.D.K. and Cheah K.S.E., Understanding the Function of Sedl gene and the Molecular Pathogenesis of spondyloepiphyseal Dysplasia Tarda., 7th Pan Pacific Connective Tissue Societies Symposium 2007 - Shangri-La Resort, Cairns, Australia. October 28 – November 1, 2007. |
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Chan C.C.Y., Understanding the Function of the SEDL Gene and the Molecular Pathogenesis of Spondyloepiphyseal Dysplasia Tarda, 12th Research Postgraduate Symposium, December 12 & 14, 2007 . 2007. |
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Researcher
: Chan CF |
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List of Research Outputs |
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Chan C.F., Lau T.W. and Leung K.L., Clinical outcome of minimally invasive plate osteosynthesis in the management of fractures of distal tibia, The 27th Hong Kong Orthopaedic Association Annual Congress, Hong Kong, 17-18 November 2007. |
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Lau T.W., Leung K.L., Chan C.F. and Chow S.P., Minimally invasive plate osteosynthesis in the treatment of proximal humeral fracture, International Orthopaedics. 2007, 31: 657-664. |
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Researcher
: Chan CW |
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List of Research Outputs |
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Chan
C.W., Gantenbein B., Leong V.Y.L., Chan D., Lu W.W., Luk K.D.K., Cheung K.M.C. and Ito K., Cell
Repopulation of the Frozen Intervertebral Disc by Bone Marrow-derived Stromal
Cells., World Forum for Spine Research - The Intervertebral Disc. |
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Cheung K.M.C., Cheng Y.L., Chan C.W., Yeung K.W.K. and Luk K.D.K., Outcome assessment of braciing in adolescent idiopathic scoliosis by the use of the SRS-22 questionnaire, International Orthopaedics. 2007, 31(4): 507-511. |
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Yeung
K.W.K., Poon R.W.Y., |
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Researcher
: Chan CW |
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List of Research Outputs |
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Chan
C.W., Gantenbein B., Leong V.Y.L., Chan D., Lu W.W., Luk K.D.K., Cheung K.M.C. and Ito K., Cell
Repopulation of the Frozen Intervertebral Disc by Bone Marrow-derived Stromal
Cells., World Forum for Spine Research - The Intervertebral Disc. |
|
Cheung K.M.C., Cheng Y.L., Chan C.W., Yeung K.W.K. and Luk K.D.K., Outcome assessment of braciing in adolescent idiopathic scoliosis by the use of the SRS-22 questionnaire, International Orthopaedics. 2007, 31(4): 507-511. |
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Yeung
K.W.K., Poon R.W.Y., |
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Researcher
: Chan YL |
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List of Research Outputs |
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Chan
Y.L., Wu S.L., Liu X.M., |
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Lam
K.O., Yeung K.W.K., Chan Y.L., Wu S.L., Liu X.M., Chung
C.Y., |
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Liu X.M., Wu S.L., |
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Liu X.M., Wu S.L., |
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Wu S.L., Liu X.M., Chan Y.L., Chung C.Y., |
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Yeung
K.W.K., Chan Y.L., Lama
K.O., Wu S.L., Liu X.M., Chung C.Y., |
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Yeung
K.W.K., Chan Y.L., Lam K.O., Liu X.M., Wu S.L., Liu X.Y.,
Chung C.Y., Lu W.W., Chan D., Luk K.D.K., |
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Researcher
: Chan Li LC |
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List of Research Outputs |
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Leung Y.L., Hung S.C., Chan Li L.C., Wu E.X., Luk K.D.K., Chan D. and Cheung K.M.C., Age-related degeneration of lumbar intervertebral discs in rabbits revealed by deuterium oxide-assisted MRI, World Forum for Spine Research - the Intervertebral Disc. 2008. |
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Leung Y.L., Hung S.C., Chan Li L.C., Wu E.X., Luk K.D.K., Chan D. and Cheung K.M.C., Aged-related degeneration of lumbar intervertebral discs in rabbits revealed by deuterium oxide-assisted MRI, World Forum for Spine Research - The Interveretegral Disc, First Japanese Meeting, Kyoto, Japan, January 23-26, 2008. |
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Luk K.D.K., Leung Y.L., Hung S.C., Tsui Y.K., Lee M.K., Chan Li L.C., Lo G.G., Masuda K., Wu E.X. and Chan D., Allogeneic mesenchymal stem cell transplantation into the intervertebral disc; effect of severity of degeneration and cell number on regeneration, 15th Triennial Congress of Asia Pacific Orthopaedic Association, Seoul, Korea, September 9-13, 2007. |
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Researcher
: Cheung KMC |
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Project Title: |
Setting Up of a Stem Cell Research Programme for Musculoskeletal Tissue Repair |
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Investigator(s): |
Cheung KMC, Chan D |
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Department: |
Orthopaedics and Traumatology |
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Source(s) of Funding: |
The |
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Start Date: |
07/2003 |
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Abstract: |
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To explore a novel method of intervertebral disc repair by implanting autologous MSCs into the degenerated intervertebral disc using a rabbit model. |
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Project Title: |
The impact of
the COL |
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Investigator(s): |
Cheung KMC, Cheah KSE, Lu WW, Chan D, Luk KDK |
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Department: |
Orthopaedics and Traumatology |
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Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
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Start Date: |
01/2005 |
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Abstract: |
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To collect and store degenerated and non-degenerated human intervertebral discs and DNA; to examine these retrieved specimens for expression of [alpha]2(IX)Trp, collagen IX cross-linking abnormalites, cellular and extracellular matrix abnormalties and alternations in mechanical properties. |
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Project Title: |
Intervertebral disc regeneration by use of mesenchymal stem cells |
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Investigator(s): |
Cheung KMC, Chan D, Wu EX, Luk KDK |
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Department: |
Orthopaedics and Traumatology |
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Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
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Start Date: |
01/2006 |
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Abstract: |
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(1) What is the fate of the transplanted MSCs within the IVD; (2) at what stage of degeneration is cell therapy most effective; (3) could allogeneic MSCs be used for transplantation; (4) what are the long term effects of transplanted MSCs. |
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Project Title: |
New compounds for intervertebral disc regeneration by Chemical Genetics |
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Investigator(s): |
Cheung KMC, Leung YL, Kao RYT, Chan D |
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Department: |
Orthopaedics and Traumatology |
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Source(s) of Funding: |
Seed Funding Programme for Basic Research |
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Start Date: |
06/2006 |
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Abstract: |
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Low back pain is a significant cause of
morbidity and disability. It is one of the most frequent reasons for clinic
visits, loss of work hours and billions of dollars of expenditure in
treatment and wage compensation. Although low back pain is complex in
aetiology, chronic low back pain is commonly associated with degeneration of
the intervertebral disc (IVD). Patients with severe IVD degeneration and pain
often require surgery with its associated morbidity.Adult IVD cells have
similar biological phenotype to chondrocytes1, using this knowledge various
biological therapies for IVD regeneration have emerged. This includes
injection of biomolecules such as OP-1/BMP-2/GDF-5 2-4 and adenoviral
delivery of Sox9 gene 5 into degenerated discs. Chemical genetics is an
emerging technique that uses small chemical compounds to alter the functions
of proteins to which they bind. The principle is similar to how genes are
manipulated in knock-out or transgenic animal models to understand the
function of a particular gene; the downstream effects of alterations of these
proteins can be evaluated to understand the function of the protein and its
pathway, hence the term "Chemical Genetics". It is thus used to
identify which proteins regulate different biological processes, to
understand in molecular detail how proteins perform their biological
functions, and to identify small compounds that may be of medical value.
Through strategic design of screening assays, this technology has been
successfully employed to identify potential pharmaceuticals for cancers 6, 7,
diabetes 8, cardiovascular diseases 9, and neurodegeneration 10, 11. The
Department of Microbiology at The University of Hong Kong has the only high
throughput chemical genetics screening platform in Asia, and they have
successfully used this technology to identify compounds that have
anti-SARS-coV and anti-angiogenesis activity 12, 13.Using the principle of
"Forward Genetics", we aim to perform a primary screen of a library
of over 50,000 small compounds using goat chondrocytes, and to select those
that are able to maintain or increase proteoglycan levels. Recent evidence
that a number of molecular pathways are involved in IVD degeneration, and
that an orally administered drug, Esculetin can reverse IVD degeneration in
rabbits 14, would support that other small compounds and pathways that may
act similarly or even more specifically can be identified. Reference list:1.
Hunter, C. J., Matyas, J. R. & Duncan, N. A. Tissue Eng 9, 667-77
(2003).2. An, H. S. et al. Spine 30, 25-31; discussion 31-2 (2005).3. Li, J.,
Yoon, S. T. & Hutton, W. C. J Spinal Disord Tech 17, 423-8 (2004).4. Li,
X., Leo, B. M., Beck, G., Balian, G. & Anderson, G. D. Spine 29, 2229-34
(2004).5. Paul, R. et al. Spine 28, 755-63 (2003).6. Lam, K. S. Anticancer
Drug Des 12, 145-67 (1997).7. Remiszewski, S. W. Curr Med Chem 10, 2393-402
(2003).8. Shi, G. Q. et al. J Med Chem 48, 4457-68 (2005).9. Bush, E. et al.
Proc Natl Acad Sci U S A 101, 2870-5 (2004).10. Apostol, B. L. et al. Proc
Natl Acad Sci U S A 100, 5950-5 (2003).11. |
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Project Title: |
Uncovering new compounds and mechanisms for treatment of intervertebral disc degeneration by chemical genetics |
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Investigator(s): |
Cheung KMC, Leung YL, Kao RYT, Chan D |
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Department: |
Orthopaedics and Traumatology |
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Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
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Start Date: |
01/2007 |
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Abstract: |
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(1) High throughput identification of compounds that can increase proteoglycan content in an in vitro culture of goat chondrocytes; (2) to investigate their possible mechanisms of action by gene expression profiling; (3) In vitro vertification that compounds with desirable molecular actions is capable of acting on human IVD cells and chondrocytes. |
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Project Title: |
MicroRNA expression and function in intervertebral disc cells |
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Investigator(s): |
Cheung KMC, Zhou G, Chan D |
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Department: |
Orthopaedics and Traumatology |
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Source(s) of Funding: |
Seed Funding Programme for Basic Research |
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Start Date: |
03/2007 |
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Abstract: |
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Degeneration of the intervertebral disc (IVD) is attributed to senescence and/or apoptosis of cells and downregulation of synthetic activities. Little is known about how these processes are regulated in IVD cells. MicroRNA (miRNA) genes have been recently recognized to play important roles in various physiological and pathological processes by their powerful regulation of gene expression, and is also known to be expressed in cartilage. Whether they are involved in the regulation of IVD cells is not known, but this information may provide new insight into the regulation of IVD degeneration and therefore ways to halt or regenerate it. This proposal aims to develop this new technology and assess the presence and regulatory roles of miRNA genes in IVD cells in comparison with chondrocytic progenitors cells by: 1) To assess and compare the expression profile of miRNA genes in nucleus pulposus (NP), annulus fibrosus (AF) cells and cartilage of young, adult and aged rats. 2) To assess and compare the expression profile of miRNA genes in NP and AF cells of human subjects. |
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List of Research Outputs |
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Abbah S.A., Lu W.W., Chan D., Cheung K.M.C., Zhao F., Li Z., Leong J.C.Y. and Luk K.D.K., Osteogenic behavior of alginate encapsulated bone marrow stromal cells: an in vitro study, J Mater Sci Mater Med. 2008, 19(5): 2113-9. |
|
Aladin Kaderbatcha D.M., Lu W.W., Cheung K.M.C., Ngan A.H.W., Chan D. and Luk K.D.K., Association of Trp2 allele with changes in morphology and nano mechanics of the human intervertebral disc collagens, Best Basic Science Paper Award for Associate Member, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. 2007. |
|
Aladin
Kaderbatcha D.M., Lu W.W., Cheung K.M.C., Ngan A.H.K., Chan D. and Luk K.D.K., Correlation between the
Compressive Macro-mechanical Properties of the Human Nucleus Pulposus and the
Nano Structure of its Individual Collagen Fibrils, World Forum for Spine
Research - The Intervertebral Disc. |
|
Aladin
Kaderbatcha D.M., Cheung K.M.C.,
Chan D., Yee A.F.Y., Jim J.J.T., Luk K.D.K. and Lu W.W., Expression of the Trp2 allele
of COL |
|
Chan
B.P., Hui T.Y., Chan G.C.F., Chan D. and Cheung K.M.C., Collagen-mesenchymal
stem cell microspheres for regenerative medicine., World Forum for Spine
Research, Kyoto, Japan (Best oral pesentation award), Jan 23-26. |
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Chan B.P., Hui T.Y., Chan G.C.F., Chan D. and Cheung K.M.C., Collagen-mesenchymal stem cell microspheres for regenerative medicine, Best Oral Presentation Award, World Forum for Spine Research - the intervertebral disc, first Japanese meeting, Kyoto, Japan, January 23-26, 2008. 2008. |
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Chan
C.W., Gantenbein B., Leong V.Y.L.,
Chan D., Lu W.W., Luk K.D.K., Cheung K.M.C. and Ito K., Cell
Repopulation of the Frozen Intervertebral Disc by Bone Marrow-derived Stromal
Cells., World Forum for Spine Research - The Intervertebral Disc. |
|
Chan
Y.L., Wu S.L., Liu X.M., |
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Cheah
K.S.E., Szeto Y.Y., Au Y.K., Wynn S., Geng G., Chan Y.S., Chan W.Y., Cheung K.M.C. and Fritzsch B.,
Context dependent impact of the Y440X campomelic dysplasia Sox9 mutation, ACGA-HKSMG
International Conference on Genetic and Genomic Medicine, |
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Cheng
H.W., Tsui K., Cheung K.M.C.,
Chan D. and Chan B.P., Decellularization of
chondrocyte-encapsulated collagen microspheres, World Forum for Spine
Research the Intervertebral Disc. |
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Cheung
K.M.C., Adjacent level degeneration, AOSpine
International |
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Cheung
K.M.C., Adjacent level degeneration, Mayo
Clinic Spine Symposium, |
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Cheung
K.M.C., Age related changes versus
degenerative disc disease, World Forum for Spine Research - the
intervertebral disc, |
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Cheung
K.M.C., Karppinen J., Chan D., Fan B., Ho D.W.H., Kao P.Y.P., Song Y., Sham P.C., Cheah K.S.E., Leong J.C.Y. and Luk K.D.K., Age-related changes versus
degenerative disc disease. World Forum for Spine Research, World Forum for
Spine Research - The Intervertebral Disc. |
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Cheung
K.M.C., Anterior surgery for deformity
correction, Mayo Clinic Spine Symposium, |
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Cheung K.M.C., Song Y., Ho D.W.H., Poon S.C.S., Chiba K., Kawaguchi Y., Hirose Y., Alini M., Grad S., Yee A.F.Y., Leong J.C.Y., Luk K.D.K., Yip S.P., Karppinen J., Cheah K.S.E., Sham P.C., Ikegawa S. and Chan D., Association of the asporin D14 allele with lumbar disc degeneration, Spineweek 2008, Geneva, Switzerland, May 26-31, 2008. |
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Cheung K.M.C., Editorial Board of European Cells and Materials, July 2007 to July 2010. 2007. |
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Cheung
K.M.C., Fusion level determination in
scoliosis surgery, Third International Congress of Spine Deformity and
Non-Fusion Techniques, |
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Cheung
K.M.C., Genetics of degenerative disc
disease, BritSpine 2008, |
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Cheung K.M.C., Honorary Visiting Professor, The Second Military Medical University, Shanghai, PR China, since March 2008. 2008. |
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Cheung
K.M.C., Intervertebral disc regeneration, AOSpine
International |
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Cheung K.M.C., Management of spinal metastases, 2008 Chinese International Spine Forum, Beijing, PR China, March 28-29, 2008. 2008. |
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Cheung
K.M.C., Management of spinal metastases, AOSpine
International |
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Cheung
K.M.C., Management of tuberculous kyphosis, Combined
Meeting of the ASEAN Orthopaedic Association and Vietnamese Orthopaedic
Association, |
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Cheung K.M.C., Cheng Y.L., Chan C.W., Yeung K.W.K. and Luk K.D.K., Outcome assessment of braciing in adolescent idiopathic scoliosis by the use of the SRS-22 questionnaire, International Orthopaedics. 2007, 31(4): 507-511. |
|
Cheung
K.M.C., Posterior versus combined excision of
thoracolumbar and lumbar hemivertebrae, Mayo Clinic Spine Symposium, |
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Cheung
K.M.C., Recent advances in management of
severe paediatric spinal deformities, Combined Meeting of the ASEAN
Orthopaedic Association and Vietnamese Orthopaedic Association, |
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Cheung K.M.C., Cheng A.C.S., Cheung W.Y., Chooi Y.S., Wong Y.W. and Luk K.D.K., Right hip adduction deficit is prevalent in patients with adolescent idiopathic scoliosis, Journal of Orthopaedic Surgery. 2008, 16(1): 24-26. |
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Cheung
K.M.C., Selection of fusion levels using the
fulcrum bending radiograph, Mayo Clinic Spine Symposium, |
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Cheung
K.M.C., TB kyphosis, 2008 Chinese
International Spine Forum, |
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Cheung
K.M.C., Thoracic spine access and their
complications, AOSpine Advance Course, |
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Cheung K.M.C., Tissue engineering of the intervertebral disc, BritSpine 2008, Belfast, Northern Ireland, April 30 - May 2, 2008. 2008. |
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Cheung K.M.C., Wu J.P., Cheng Q.H., Ma S.C., Gao J.C. and Luk K.D.K., Treatment of stiff thoracic scoliosis by thoracoscopic anterior release combined with posterior instrumentation and fusion: a retrospective study, The Journal of Orthopaedic Surgery and Research. 2007, 2(1): 16. |
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Cheung W.Y., Arvinte D., Wong Y.W., Luk K.D.K. and Cheung K.M.C., Neurological recovery after surgical decompression in patients with cervical spondylotic myelopathy - a prospective study, International Orthopaedics. 2008, 32(2): 273-278. |
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Guo C.X., Irwin M.G., Cheung K.M.C. and Chan D., An effective dose of Valdecoxib in experimental mouse models of pain, Methods Find Exp Clin Pharmacol. 2007, 29(6): 383-388. |
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Ho D.W.H., Chan D., Cheung K.M.C., Sham P.C. and Song Y., Family-base linkage and case control association studies, Current Orthopaedics. 2008, 22: 245-250. |
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Ho D.W.H., Cheung K.M.C., Chan D., Cheah K.S.E., Karppinen J., Sham P.C. and Song Y., LINKAGE ANALYSIS WITH SUBSEQUENT FINE-MAPPING ON FAMILIAL EARLY ONSET-DEGENERATIVE DISC DISEASE, SpineWeek 2008, Geneva, SWITZERLAND. 2008. |
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Ho D.W.H., Cheung K.M.C., Chan D., Karppinene J., Yip S.P., Ott J., Luk K.D.K., Leong J.C.Y., Cheah K.S.E., Sham P.C. and Song Y., Linkage Analysis on Familial Early-onset Degenerative Disc Disease, 12th Research Postgraduate Symposium, December 12 & 14, 2007 . 2007. |
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Ho
D.W.H., Cheung K.M.C., Chan D., Karppinen J., Yip S.P., Ott J.,
Luk K.D.K., Leong J.C.Y., Cheah K.S.E., Sham P.C. and Song Y., Linkage analysis on familial
early-onset degenerative disc disease. World Forum for Spine Research., The
Intervertebral Disc. |
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Ho D.W.H., Cheung K.M.C., Chan D., Cheah K.S.E., Karppinen J., Sham P.C. and Song Y., Linkage analysis with subsequent fine-mapping on familial early onset-degenerative disc disease., Spine Week 2008, Geneva, May 26-31, 2008. |
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Ho G., Leung Y.L., Chan D. and Cheung K.M.C., Effect of severity of intervertebral disc injury on mesenchymal stem cell-based regeneration, Connective Tissue Research. 2008, 49: 15-21. |
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Hu Y., Ding Y., Yuan D., Wong Y.W., Cheung K.M.C. and Luk K.D.K., Prognostic value of somatosensory-evoked potentials in the surgical management of cervical spondylotic myelopathy, Spine. 2008, 33: E305-10. |
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Hui T.Y., Cheung K.M.C., Cheung W.L., Chan D. and Chan B.P., In vitro chondrogenic differentiation of human mesenchymal stem cells in collagen microspheres: influence of cell seeding density and collagen concentration, Biomaterials. Elsevier Ltd., 2008, 29: 3201-3212. |
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Kao P.Y.P., Chan D., Cheah K.S.E., Cheung K.M.C., Karppinene J., Yip S.P., Sham P.C. and Song Y., Genome-wide Association Study of Degenerative Disc Disease (DDD) , 12th Research Postgraduate Symposium, December 12 & 14, 2007 . 2007. |
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Kao P.Y.P., Chan D., Cheung K.M.C., Ho D.W.H., Karppinen J., Leong J.C.Y., Luk K.D.K., Yip S.P., Cheah K.S.E., Song Y. and Sham P.C., Genome-wide association study of degenerative disc disease (DDD)., Spine Week 2008, Geneva, May 26-31, 2008. . 2008. |
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Kao
P.Y.P., Chan D., Cheah K.S.E., Cheung K.M.C., Ho D.W.H., Karppinen J., Leong J.C.Y., Luk K.D.K., Yip S.P., Song Y. and Sham P.C., Genome-wide association study
of degenerative disc disease (DDD)., World Forum for Spine Research - The
Intervertebral Disc. |
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Kao P.Y.P., Chan D., Cheung K.M.C., Ho D.W.H., Karppinen J., Leong J.C.Y., Luk K.D.K., Yip S.P., Cheah K.S.E., Song Y., Sham P.C. and Sham P.C., Genome-wide association study of degenerative disc disease, Spineweek 2008, Geneva, Switzerland, May 26-31, 2008. |
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Lam
K.O., Yeung K.W.K., Chan Y.L., Wu S.L., Liu X.M., Chung
C.Y., |
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Leung Y.L., Hung S.C., Li L.C., Wu E.X., Luk K.D.K., Chan D. and Cheung K.M.C., Age-related degeneration of lumbar intervertebral disc in rabbit reveal by deuterium oxide-assisted MRI, Best Poster Award, World Forum for Spine Research - the intervertebral disc, first Japanese meeting, Kyoto, Japan, January 23-26, 2008 . 2008. |
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Leung Y.L., Hung S.C., Chan Li L.C., Wu E.X., Luk K.D.K., Chan D. and Cheung K.M.C., Age-related degeneration of lumbar intervertebral discs in rabbits revealed by deuterium oxide-assisted MRI, World Forum for Spine Research - the Intervertebral Disc. 2008. |
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Leung Y.L., Hung S.C., Chan Li L.C., Wu E.X., Luk K.D.K., Chan D. and Cheung K.M.C., Aged-related degeneration of lumbar intervertebral discs in rabbits revealed by deuterium oxide-assisted MRI, World Forum for Spine Research - The Interveretegral Disc, First Japanese Meeting, Kyoto, Japan, January 23-26, 2008. |
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Leung Y.L., Wu E.X., Luk K.D.K., Chan D. and Cheung K.M.C., Cell quantity and degenerative stage dependent effect of allogeneic mesenchymal stem cells on regeneration of intervertebral disc, 14th International Meeting on Advanced Spine Techniques. 2007. |
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Li Z., Yang C., Lu W.W., Xu B., Lam R.W.M., Ni G., Abbah S.A., Yang F., Cheung K.M.C. and Luk K.D.K., Characteristics and mechanical properties of acrylolpamidronate-treated strontium containing bioactive bone cement, J Biomed Mater Res B Appl Biomater. 2007, 83(2): 464-71. |
|
Li Z., Lu W.W., Lam R.W.M., Chiu P.K.Y., Cheung K.M.C. and Luk K.D.K., Micro-architectural and Nano-mechanical Properties of Trabecular Bone with Strontium Treatment in Osteoporotic Goats, 9th Regional Osteoporosis Conference, Hong Kong. 2008. |
|
Li Z., Lu W.W., Chiu P.K.Y., Lam R.W.M., Tang B., Ngan A.H.W., Wong C.T., Fang D., Cheung K.M.C. and Luk K.D.K., Micro-architectural and nano-mechanical properties of trabecular bone with strontium treatment in large animal model of osteoporosis, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2007, 11: S80. |
|
Li Z., Lu W.W., Chiu P.K.Y., Lam R.W.M., Tang B., Ngan A.H.W., Wong C.T., Fang D., Cheung K.M.C. and Luk K.D.K., Micro-architectural and nano-mechanical properties of trabecular bone with strontium treatment in large animal model of osteoporosis, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Li Z., Lu W.W., Chiu P.K.Y., Lam R.W.M., Cheung K.M.C., Tang B., Ngan A.H.W. and Luk K.D.K., Micro-architecture and Nano-mechanics of Lumbar Vertebra with Strontium Treatment in Large Animal Model of Osteoporosis, 54th Annual Meeting of the Orthopaedic Research Society, San Francisco, USA. 2008, P276. |
|
Lie C.W.H., Cheung K.M.C., Fan B.J., Karpinnen J., Leong J.C.Y. and Luk K.D.K., Can age-related intervertebral disc changes be differentiated from degenerative disc disease, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Liu X.M., Wu S.L., |
|
Liu X.M., Wu S.L., |
|
Lu W.W., Li Z., Chiu P.K.Y., Lam R.W.M., Yang C., Xu B., Wong C.T., Fang D., Cheung K.M.C. and Luk K.D.K., Bone composition and mineral crystal structure after strontium treatment for osteoporosis in goat model, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2007, 11: S79. |
|
Lu W.W., Li Z., Chiu P.K.Y., Lam R.W.M., Yang C., Xu B., Wong C.T., Fang D., Cheung K.M.C. and Luk K.D.K., Bone composition and mineral crystal structure after strontium treatment for osteoporosis in goat model, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Lu W.W., Li Z., Chiu P.K.Y., Lam R.W.M., Cheung K.M.C., Fang D., Leong J.C.Y. and Luk K.D.K., Mineral Crystal Composition and Structure of New Bone after Strontium Treatment for Osteoporosis in Goat Model, 54th Annual Meeting of the Orthopaedic Research Society, San Francisco, USA. 2008, P966. |
|
Lu W.W., Peng S.L., Zhou G., Luk K.D.K., Li Z., Wong C.T., Lam R.W.M. and Cheung K.M.C., Strontium promotes osteogenic differentiation and inhibits the osteoclastogenic potentials in murine mesenchymal stem cells, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Ni G.X., Lu W.W., Tang B., Ngan A.H.W., Chiu K.Y., Cheung K.M.C., Li Z. and Luk K.D.K., Effect Of Weight-bearing On
Bone-bonding Behavior Of Strontium-containing Hydroxyapatite Bone Cement, Journal
Of Biomedical Materials Research Part A. 111 RIVER ST, HOBOKEN, NJ 07030
USA, WILEY-LISS, DIV JOHN WILEY & SONS INC, 2007, |
|
Poon R.W.Y., |
|
Song Y., Ho D.W.H., Karppinen J., Kao P.Y.P., Fan B.J., Luk K.D.K., Yip S.P., Leong J.C.Y., Cheah K.S.E., Sham P.C., Chan D. and Cheung K.M.C., Association between promoter-1607 polymorphism of MMP1 and lumbar disc disease in Southern Chinese, BMC Medical Genetics. 2008, 9(1): 38. |
|
Song Y., Cheung K.M.C., Ho D.W.H., Poon S.C.S., Chiba K., Kawaguchi Y., Hirose Y., Alini M., Grad S., Yee A.F.Y., Leong J.C.Y., Luk K.D.K., Yip S.P., Karppinen J., Cheah K.S.E., Sham P.C., Ikegawa S. and Chan D., Association of the asporin D14 allele with lumbar disc degeneration in Asians, American Journal of Human Genetics. 2008, 82(3): 744-747. |
|
Song Y., Cheung K.M.C., Ho D.W.H., Poon S.C.S., Chiba K., Kawaguchi Y., Hirose Y., Alini M., Grad S., Yee A.F.Y., Leong J.C.Y., Luk K.D.K., Yip S., Karppinen J., Cheah K.S.E., Sham P.C., Ikegawa S. and Chan D., Genetic Risk Factors For Intervertebral Disc Degeneration, 7th Pan Pacific Connective Tissue Societies Symposium 2007 - Shangri-La Resort, Cairns, Australia, 28 October - 1 November 2007. |
|
Song Y., Sham P.C., Cheung K.M.C. and Chan D., Genetics of disc degeneration, Current Orthopaedics. 2008, 22: 259-266. |
|
Song
Y., Chan D., Kao P.Y.P., Ho D.W.H., Fan B., Karpinen J., Yip S.Y., Leong J.C.Y., Luk K.D.K., Ott J., Cheah K.S.E., Sham P.C. and Cheung K.M.C., Three genes in the
aggrecan degradation pathway act synergistically to predispose to
degenerative disc disease., World Forum for Spine Research - The
Intervertebral Disc. |
|
Takemitsu M., Cheung K.M.C., Wong Y.W., Cheung W.Y. and Luk K.D.K., C5 nerve root palsy after cervical laminoplasty and fusion with instrumentation, Journal of Spinal Disorders and Techniques. 2008, 21: 267-272. |
|
Tam W.K., Cheung K.M.C., Chan D., Leong V.Y.L., Luk K.D.K. and Zhou G.Q., Both HIF-1aand HIF-2aare Present in
Prenatal and Postnatal Nucleus., World Forum for Spine Research - The
Intervertebral Disc. |
|
Tsui
Y.K., Leung Y.L., Kao R.Y.T., Chan D., Masuda K. and Cheung K.M.C., High throughput
screening of chemical compounds for the treatment of osteoarthritis, Best
Poster Award, 12th Ressearch Postgraduate Symposium, The |
|
Tsui
Y.K., Leung Y.L., Kao R.Y.T., Chan D., Masuda K. and Cheung K.M.C., Identification of
Chemical Compounds for the Treatment of Intervertebral Disc Degeneration with
the Application of High-throughput Screening, World Forum for Spine
Research - The Intervertebral Disc. |
|
Wong
H.M., Yeung K.W.K., Lam K.O., |
|
Wong K., Cheung K.M.C., Karpinnen J., Fan
B.J., Leong J.C.Y. and Luk K.D.K., Relationship between magnetic
resonance imaging changes of the lumbar spine and low back pain: a magnetic
resonance imaging study of 1043 population-based subjects, 27th Annual
Congress of the Hong Kong Orthopaedic Association, |
|
Wong K., Don A.S., Chong C.S., Wong Y.W., Cheung K.M.C. and Luk K.D.K., Selection of fusion levels in adolescent idiopathic scoliosis using fulcrum bending prediction - a prospective study, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Wong Y.W., Lie C.W.H., Cheung K.M.C. and Luk K.D.K., Cervical total vertebrectomy - a case report, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Wong Y.W., Cheung K.M.C., Cheung W.Y. and Luk K.D.K., Evolution of managing spinal metastasis causing neurological deficit in ten years' period, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Wong Y.W., Cheung W.Y., Cheung K.M.C. and Luk K.D.K., Initial experience in the expansion thoracoplasty for severe congenital scoliosis, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Wong
Y.W., Cheung K.M.C. and Luk K.D.K., Management strategies of
intraoperative haemorrhage from the vertebral artery, 27th Annual Congress
of the Hong Kong Orthopaedic Association, |
|
Wong Y.W., Cheung K.M.C., Cheung W.Y. and Luk K.D.K., Reduction osteotomy or intravertebral structural support for the thoracolumbar osteoporotic fracture - minimal surgery to get maximal stabilization, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Wu S.L., Liu X.M., Chan Y.L., Chung C.Y., |
|
Yang
F., Chan D., Leung Y.L., Lu W.W., Luk K.D.K. and Cheung K.M.C., Dynamic Changes of
Type II Collagen in the Degenerated Murine Discs., World Forum for Spine
Research - The Intervertebral Disc. |
|
Yee
A.F.Y., Melhado I.G., Cheah K.S.E., Cheung K.M.C. and Chan D., Protein expression of the
intervertebral disc: in Health and disease., World Forum for Spine
Research - The Intervertebral Disc. |
|
Yee
A.F.Y., Melhado I.G., Cheah K.S.E., Chan D. and Cheung K.M.C., Use of tandem mass
spectrometry as a tool for proteomics studies in aging and degeneration
processes of the intervertebral disc., Spine Week 2008, |
|
Yee
A.F.Y., Melhado I.G., Cheah K.S.E., Chan D. and Cheung K.M.C., Use of tandem mass
spectrometry as a tool for proteomics studies in aging and degeneration
processes of the intervertebral disc, Spineweek 2008, |
|
Yeung
K.W.K., Chan Y.L., Lama K.O., Wu
S.L., Liu X.M., Chung C.Y., |
|
Yeung
K.W.K., Chan Y.L., Lam K.O., Liu X.M., Wu S.L., Liu X.Y.,
Chung C.Y., Lu W.W., Chan D., Luk K.D.K., |
|
Yeung
K.W.K., Poon R.W.Y., |
|
Zheng Z.M., Luk K.D.K., Kuang G.M., Li Z., Lin J., Lam R.W.M., Cheung K.M.C. and Lu W.W., Vertebral augmentation with a novel vessel-x bone void filling container system and ioactive bone cement, Spine. 2007, 32(19): 2076-2082. |
|
Zhou X.Z., Leung Y.L., Dong Q.R., Cheung K.M.C., Chan D. and Lu W.W., Mesenchymal stem cell-based repair of articular cartilage with polyglycolic acid-hydroxyapatite biphasic scaffold, Int J Artif Organs. 2008, 6: 480-9. |
|
List of Research Outputs |
|
Cheung K.M.C., Cheng A.C.S., Cheung W.Y., Chooi Y.S., Wong Y.W. and Luk K.D.K., Right hip adduction deficit is prevalent in patients with adolescent idiopathic scoliosis, Journal of Orthopaedic Surgery. 2008, 16(1): 24-26. |
|
Cheung W.Y., Arvinte D., Wong Y.W., Luk K.D.K. and Cheung K.M.C., Neurological recovery after surgical decompression in patients with cervical spondylotic myelopathy - a prospective study, International Orthopaedics. 2008, 32(2): 273-278. |
|
Takemitsu M., Cheung K.M.C., Wong Y.W., Cheung W.Y. and Luk K.D.K., C5 nerve root palsy after cervical laminoplasty and fusion with instrumentation, Journal of Spinal Disorders and Techniques. 2008, 21: 267-272. |
|
Wong Y.W., Cheung K.M.C., Cheung W.Y. and Luk K.D.K., Evolution of managing spinal metastasis causing neurological deficit in ten years' period, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Wong Y.W., Cheung W.Y., Cheung K.M.C. and Luk K.D.K., Initial experience in the expansion thoracoplasty for severe congenital scoliosis, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Wong Y.W., Cheung K.M.C., Cheung W.Y. and Luk K.D.K., Reduction osteotomy or intravertebral structural support for the thoracolumbar osteoporotic fracture - minimal surgery to get maximal stabilization, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Project Title: |
The effect of bisphosphonate on established osteolytic lesions--a study of different approach and dosage in rabbit hip replacement model |
|
Investigator(s): |
|
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2003 |
|
Abstract: |
|
To study the effect of different approach and dosage of bisphosphonate on bone loss in previous established rabbit osteolysis model after hip joint replacement. |
|
List of Research Outputs |
|
Chiu
P.K.Y., Asian knees - not just smaller but
different, Proceedings of the 15th Congress of Asia Pacific Orthopaedic
Association, |
|
Chiu P.K.Y., Changing environment - expectations and requirements (Keynote speech), LCS 30-year anniversary meeting - An implant for life, organized by Depuy, Johnson & Johnson, September 25-27, 2007 at Dublin, Ireland. 2007. |
|
Chiu
P.K.Y., Hip arthroplasty for failed internal
fixation of intertrochanteric fractures, Proceedings of the 15th Congress
of Asia Pacific Orthopaedic Association, |
|
Chiu
P.K.Y., Instructional Course Lecture: Asian
knees - not just smaller but different, 15th Triennial Congress of Asia
Pacific Orthopaedic Association, Sept 9-13, 2007 at COEX, |
|
Chiu P.K.Y., Instructional course lecture: rotational alignment of the femoral components in total knee arthroplasty, "Ninth National Congress of Orthopaedic Surgery and the Second International Congress of Chinese Orthopaedic Association", organized by Chinese Medical Association & Chinese Orthopaedic Association, November 9-11, 2007 at Beijing, China. 2007. |
|
Chiu
P.K.Y., Revision total hip replacement: the
femoral site, "International symposium in hip surgery and
arthroscopy", organized by |
|
Chiu
P.K.Y., Special lecture: Hip arthroplasty for
failed internal fixation of intertrochanteric fractures, 15th Triennial
Congress of Asia Pacific Orthopaedic Association, Sept 9-13, 2007 at COEX, |
|
Chiu P.K.Y., Surgical tips to improve on range of motion, LCS 30-year anniversary meeting - An implant for life, organized by Depuy, Johnson & Johnson, September 25-27, 2007 at Dublin, Ireland. 2007. |
|
Chiu P.K.Y., The dragon knee study, LCS 30-year anniversary meeting - An implant for life, organized by Depuy, Johnson & Johnson, September 25-27, 2007 at Dublin, Ireland. 2007. |
|
Fang
D., Chiu P.K.Y., Tang W.M. and Fang C., Asian total hip
system: Clinical and radiological results at 11 years, 15th Triennial
Congress of |
|
Fang D., Chiu P.K.Y., Tang W.M. and Fang C., Asian total hip system: clinical and radiological results at 11 years, Proceedings of the 15th Congress of Asia Pacific Orthopaedic Association, Seoul, Korea, September 9-13, 2007. 226. |
|
Gibson I., Chow S.P., Lam K.W., Lu W.W., NGAN H.W., Ip W.Y. and Chiu P.K.Y., The Development Of An
Artifical Finger Joint, In: Paulo Bartolo, Bopaya Bidanda, Bio-materials
And Prototyping Applications In Medicine. |
|
Hang B.Y. and Chiu P.K.Y., Clinical implication of pelvic measurements on acetabular component location in development dysplasia of the hip, 骨盆相關數據測量對髋臼發育不良髋臼定位的臨床意義, Orthopaedic Jorunal of China. 中國矯形外科雜誌, 2007, 15: 1167-1168. |
|
Ho Y.W., Yeung J.S.L., Chiu P.K.Y., Tang W.M., Lin Z.B., Man R.Y.K. and Lau W.C.S., Ganoderma lucidum polysaccharide peptide reduced the production of pro-inflammatory cytokines in activated rheumatoid synovial fibroblast, Molecular & Cellular Biochemistry. 2007, 301(1-2): 173-179. |
|
Hsu Y.C., Cheng H.C., Ng T.P. and Chiu P.K.Y., Antibiotic-loaded cement articulating spacer for 2-stage reimplantation in infected total knee arthroplasty - a simple and economic method, The Journal of Arthroplasty. 2007, 22(7): 1060-1066. |
|
Ip W.Y., Chow S.P., Lam K.W., Gibson I., Ngan A.H.W., Lu W. and Chiu P.K.Y., A Novel Artificial Prosthetic Replacement For The Proximal Interphalangeal Joint Of The Hand - From Concept To Prototype, Australian Orthopaedic Association Continuing Orthopaedic Education Meeting . 2008. |
|
Lam R.W.M., Wong C.T., Li Z., Luk K.D.K., Chan W.K., Yang C., Chiu P.K.Y., Xu B. and Lu W.W., Solvothermal synthesis of strontium phosphate chloride nanowire, Journal of Cystal Growth. 2007, 306: 129-134. |
|
Lam W.M.R., Wong C.T., Li Z., Luk K.D.K., Chan W.K., Yang C., Chiu P.K.Y., Xu B. and Lu W.W., Solvothermal synthesis of strontium phosphate chloride nanowire., Journal of Crystal Growth. 2007, 306 (1): 129-134. |
|
Li Z., Lu W.W., Lam R.W.M., Chiu P.K.Y., Cheung K.M.C. and Luk K.D.K., Micro-architectural and Nano-mechanical Properties of Trabecular Bone with Strontium Treatment in Osteoporotic Goats, 9th Regional Osteoporosis Conference, Hong Kong. 2008. |
|
Li Z., Lu W.W., Chiu P.K.Y., Lam R.W.M., Tang B., Ngan A.H.W., Wong C.T., Fang D., Cheung K.M.C. and Luk K.D.K., Micro-architectural and nano-mechanical properties of trabecular bone with strontium treatment in large animal model of osteoporosis, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2007, 11: S80. |
|
Li Z., Lu W.W., Chiu P.K.Y., Lam R.W.M., Tang B., Ngan A.H.W., Wong C.T., Fang D., Cheung K.M.C. and Luk K.D.K., Micro-architectural and nano-mechanical properties of trabecular bone with strontium treatment in large animal model of osteoporosis, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Li Z., Lu W.W., Chiu P.K.Y., Lam R.W.M., Cheung K.M.C., Tang B., Ngan A.H.W. and Luk K.D.K., Micro-architecture and Nano-mechanics of Lumbar Vertebra with Strontium Treatment in Large Animal Model of Osteoporosis, 54th Annual Meeting of the Orthopaedic Research Society, San Francisco, USA. 2008, P276. |
|
Liu
K., Chiu P.K.Y., |
|
Liu K.G., Chiu P.K.Y., |
|
Lu W.W., Li Z., Chiu P.K.Y., Lam R.W.M., Yang C., Xu B., Wong C.T., Fang D., Cheung K.M.C. and Luk K.D.K., Bone composition and mineral crystal structure after strontium treatment for osteoporosis in goat model, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2007, 11: S79. |
|
Lu W.W., Li Z., Chiu P.K.Y., Lam R.W.M., Yang C., Xu B., Wong C.T., Fang D., Cheung K.M.C. and Luk K.D.K., Bone composition and mineral crystal structure after strontium treatment for osteoporosis in goat model, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Lu W.W., Li Z., Chiu P.K.Y., Lam R.W.M., Cheung K.M.C., Fang D., Leong J.C.Y. and Luk K.D.K., Mineral Crystal Composition and Structure of New Bone after Strontium Treatment for Osteoporosis in Goat Model, 54th Annual Meeting of the Orthopaedic Research Society, San Francisco, USA. 2008, P966. |
|
Ng F.Y., Wong H.L., Yau W.P., Chiu P.K.Y. and Tang W.M., Comparison of range of motion after standard and high-flexion posterior stabilized total knee replacement., International Orthopaedics. 2008, Online publication. |
|
Ng
F.Y., Yau W.P., Tang W.M. and Chiu P.K.Y., How Accurate Can We
Determine the Rotational Alignment of Femoral Prosthesis in Total Knee
Replacment?, |
|
Ng
F.Y., Yau W.P., Tang W.M. and Chiu P.K.Y., How accurate can we
determine the rotational alignment of femoral prosthesis in total knee
replacement?, 27th Annual Congress of the Hong Kong Orthopaedic
Association, |
|
Ng J.K.F., Lawmin J.C., Li C.F., Tsang S.F., Tang W.M. and Chiu P.K.Y., Comprehensive evaluation of platelet dysfunction in patients taking diclofenac before joint arthroplasties, Journal of Arthroplasty. 2008, 23: 424-430. |
|
Ng J.K.F., Lawmin J.C., Li C.C.F., Tsang S.F., Tang W.M. and Chiu P.K.Y., Comprehensive preoperative evaluation of platelet function in total knee arthroplasty patients taking diclofenac., J Arthroplasty. 2008, 23: 424-30. |
|
Ng J.K.F., Lawmin J.C., Tsang S.F., Tang W.M. and Chiu P.K.Y., PFA-100 closure times and blood loss during total knee arthroplasty in patients taking NSAIDs, HAA 2007 Combined Annual Scientific Meeting of the Haematology Society of Australia & New Zealand, the Australian & New Zealand Society of Blood Transfusion, and the Australasian Society of Thrombosis & Haemostasis. 2007. |
|
Ng J.K.F., Lawmin J.C., Tsang S.F., Tang W.M. and Chiu P.K.Y., PFA-100 closure times and postoperative blood loss after total knee arthroplasty in patients taking NSAIDs, XXIst International Symposium on Technological Innovations in Laboratory Hematology, Sydney Convention Centre, Sydney, Australia, April 28 - May 1, 2008. |
|
Ng
J.K.F., Lawmin J.C., Tsang S.F., Tang W.M. and Chiu P.K.Y., PFA-100 closure times and postoperative blood loss after total knee
arthroplasty in patients taking NSAIDs, Int J Lab Hematol 2008. 30
Suppl1: |
|
Ng T.P., Miu Y.S., Chiu P.K.Y., Tang W.M. and Yau W.P., Early Experience of Minimally Invasive Surgery Total Knee Arthroplasty Performed with Computer Navigation, Hong Kong Journal of Orthopaedic Surgery. 2007, 11: S44. |
|
Ng
T.P., Miu Y.S. and Chiu P.K.Y.,
Early experience of minimally invasive surgery total knee arthroplasty
performed with computer navigation, 27th Annual Congress of the Hong Kong
Orthopaedic Association, |
|
Ni G., Lu W.W., Chiu P.K.Y., Wang Y., Li Z., Zhang Y.G., Xu B., Deng L.F. and Luk K.D.K., Mechanical properties of femoral cortical bone following cemented hip replacement, Journal of Orthopaedic Research. 2007, 1408-1414. |
|
Tang
W.M. and Chiu P.K.Y.,
Cementing new liner into well fixed cementless cup, 15th Triennial
Congress of |
|
Tang
W.M. and Chiu P.K.Y.,
Cementing new liner into well fixed cementless cup, 27th Annual Congress
of the Hong Kong Orthopaedic Association, |
|
Tang
W.M. and Chiu P.K.Y.,
Cementing new liner into well fixed cementless cup, Proceedings of the
15th Congress of Asia Pacific Orthopaedic Association, |
|
Tang W.M. and Chiu P.K.Y., Letter to editor: Variances in sagittal femoral shaft bowing in patterns undergoing TKA, Clinical Orthopeadics & Related Research. 2008, 466(4): 1008-9. |
|
Tang
W.M. and Chiu P.K.Y.,
Poster: Sagittal pelvic Mal-rotation and positioning of the acetabular
component, 15th Triennial Congress of |
|
Tang
W.M. and Chiu P.K.Y.,
Sagittal bowing of the distal femur in Chinese patients, 15th Triennial
Congress of |
|
Tang
W.M. and Chiu P.K.Y.,
Sagittal bowing of the distal femur in Chinese patients, Proceedings of
the 15th Congress of Asia Pacific Orthopaedic Association, |
|
Tang
W.M. and Chiu P.K.Y.,
Sagittal pelvic mal-rotation and positioning of the acetabular component, Proceedings
of the 15th Congress of Asia Pacific Orthopaedic Association, |
|
Wong K., Ng T.P. and Chiu P.K.Y., Hip pain after years of hip fusion, Journal of Bone & Joint Surgery (British). 2008, 90B: 510-511. |
|
Wong K.L., Tang W.M., Lu W.W., Cheung W.L. and Chiu P.K.Y., Mechanical properties of polyetheretherketone-strontium hydroxyapatite composites , 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2007, 11: S111. |
|
Yau
W.P., Leung A., Liu K.G., Yan C.H. and Chiu P.K.Y., Can minimal incision
approach be combined with computer assisted navigation total knee
replacement? - a cadaveric study, Proceedings of the 15th Congress of Asia
Pacific Orthopaedic Association, |
|
Yau
W.P., Leung A., Liu K., Yan C.H.
and Chiu P.K.Y., Can minimal
incision approach be combined with computer assisted navigation total knee
replacement? – A cadaveric study, 15th Triennial Congress of |
|
Yau W.P., Chiu P.K.Y., Tang W.M. and Ng T.P., Comparison of range of motion after standard and hi-flexion posterior stabilized total knee replacement, Proceedings of the 15th Congress of Asia Pacific Orthopaedic Association, Seoul, Korea, September 9-13, 2007. 246-7. |
|
Yau
W.P., Chiu P.K.Y., Tang W.M. and Ng T.P., Comparison of range of motion
after standard and high-flexion posterior stabilized total knee replacement, 15th
Triennial Congress of |
|
Yau
W.P., Chiu P.K.Y. and Fok
M., Computer Navigated Articulated Cement Spacers (IGS PROSTALAC) for
Infected Total Knee Replacement, |
|
Yau
W.P., Chiu P.K.Y. and Fok
M., Computer navigated articulated cement spacers (IGS prostalac) for
infected total knee replacement, 27th Annual Congress of the Hong Kong
Orthopaedic Association, |
|
Yau
W.P., Chiu P.K.Y., Zuo J., Tang W.M. and Ng T.P., Computer navigation did not
improve alignment in a lower-volume total knee practice , 8th Annual
Meeting of Computer Assisted Orthopaedic Surgery -International Association.
2008, June 5-7, |
|
Yau W.P., Chiu P.K.Y. and Tang W.M., Computer navigation did not improve alignment in a lower-volume total knee practice, Clinical Orthopaedic Related Research. 2008, 466: 935-945. |
|
Yau W.P. and Chiu P.K.Y., Cutting Errors in Total Knee Replacement: Assessment by Computer Assisted Surgery., Knee Surgery, Sports Traumatology, Arthroscopy. 2008, 16(7): 670-673. |
|
Yau
W.P., Chiu P.K.Y. and Yan
C.H., Cutting Errors in Total Knee Replacement, |
|
Yau
W.P., Chiu P.K.Y. and Yan
C.H., Cutting errors in total knee replacement, 27th Annual Congress of
the Hong Kong Orthopaedic Association, |
|
Yau
W.P., Liu K., Yan C.H. and Chiu P.K.Y., Errors in
Identification of the Distal Femur Transepicondylar and Anterior Posterior
Axes in Minimal Incision TKR and Conventional Incision TKR Using Image Free
Computer Navigation System, 8th Annual Meeting of Computer Assisted
Orthopaedic Surgery -International Association. 2008, June 5-7, |
|
Yau
W.P. and Chiu P.K.Y.,
Errors in Identification of the Distal Femur Transepicondylar and Anterior
Posterior Axes in Minimal Incision Total Knee Replacement and Conventional
Incision Total Knee Replacement – A Cadaveric Study, 27th Annual Congress
of the |
|
Yau
W.P. and Chiu P.K.Y.,
Errors in Identification of the Distal Femur Transepicondylar and Anterior
Posterior Axes in Minimal Incision Total Knee Replacement and Conventional
Incision Total Knee Replacement – A Cadaveric Study, |
|
Yau W.P., Leung A., Liu K.G., Yan C.H., Wong L.L.S. and Chiu P.K.Y., Errors in identification of the distal femur transepicondylar and anterior posterior axes in minimal incision total knee replacement and conventional incision total knee replacement - a cadaveric study, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2007, 11: S40. |
|
Yau W.P., Leung A., Liu K.G., Yan C.H., Wong L.S. and Chiu P.K.Y., Errors in the identification of the transepicondylar and anteroposterior axes of the distal femur in total knee replacement using minimally-invasive and conventional approaches: A cadaver study, The Journal of Bone & Joint Surgery (Br). 2008, 90-B: 520-526. |
|
Yau W.P., Chiu P.K.Y. and Tang W.M., How Precise is the Determination of Rotational Alignment of the Femoral Prosthesis in Total Knee Arthroplasty. An in vivo Study., Journal of Arthroplasty. 2007, 22: 1042-1048. |
|
Yau W.P., Leung A., Liu K.G., Yan C.H., Wong L.L.S. and Chiu P.K.Y., Interobserver and intra-observer errors in obtaining visually selected anatomical landmarks during registration process in non-image-based navigation-assisted total knee arthroplasty, The Journal of Arthroplasty. 2007, 22(8): 1150-1161. |
|
Yau
W.P. and Chiu P.K.Y.,
Prospective Randomized Controlled Trial Comparing |
|
Yau
W.P. and Chiu P.K.Y.,
Prospective Randomized Controlled Trial Comparing |
|
Yau
W.P. and Chiu P.K.Y.,
Prospective Randomized Controlled Trial Comparing |
|
Yau
W.P. and Chiu P.K.Y.,
Prospective randomised controlled trial comparing range of motion after
standard and high-flexion posterior stabilised total knee prosthesis, 27th
Annual Congress of the Hong Kong Orthopaedic Association, |
|
Yau
W.P. and Chiu P.K.Y.,
Radiographic Alignment of the Implanted Prosthesis in Computer Navigation
Total Knee Replacement – A Case Control Study, 27th Annual Congress of the
|
|
Yau
W.P. and Chiu P.K.Y.,
Radiographic Alignment of the Implanted Prosthesis in Computer Navigation
Total Knee Replacement – A Case Control Study, |
|
Yau W.P. and Chiu P.K.Y., Radiographic alignment of the implanted prosthesis in computer navigation total knee replacement - a case control study, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2007, 11: S39. |
|
Yau
W.P., Chiu P.K.Y., Yan
C.H., Tang W.M. and Ng T.P., What have I learned after
adopting computer navigation in total knee replacement?, 5th Annual
Meeting of Asian Society for Computer Assisted Orthopaedic Surgery. 2008,
June 4, |
|
Researcher
: Chooi YS |
|
List of Research Outputs |
|
Cheung K.M.C., Cheng A.C.S., Cheung W.Y., Chooi Y.S., Wong Y.W. and Luk K.D.K., Right hip adduction deficit is prevalent in patients with adolescent idiopathic scoliosis, Journal of Orthopaedic Surgery. 2008, 16(1): 24-26. |
|
Researcher
: Chow SP |
|
Project Title: |
Novel prosthetic replacements for metacarpophalangeal (MCP) joints |
|
Investigator(s): |
Chow SP, Ngan AHW, |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2005 |
|
Abstract: |
|
To reproduce the anatomical shape in order to achieve a good range of movement and to interact with the soft tissue in achieving the necessary stability; to have the right material for both the surface and the stem of the implant. |
|
Project Title: |
An animal model for vascularised nerve graft in complete spinal cord transection |
|
Investigator(s): |
Chow SP, |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
01/2006 |
|
Abstract: |
|
Objectives :To establish an aminal model where a vascularised nerve graft can be used to bridge a complete transection of the spinal cord.Key issues and problem being addressed :In the past 20 years or so, attempts to achieve regeneration of the spinal cord across a defect left after spinal cord injury were directed towards three aspects :-a. To promote regeneration of the nerves by various active substances such as growth factorsb. To neutralise the inhibitors of regenerationc. To bridge the gap with all kinds of conduits and cells.The use of the peripheral nerve graft, which is highly successful in the peripheral nervous system, may be able to help bridge the gap, provide growth factors, or even neutralize the inhibitors. Indeed, Cajal, Kao, Wardrope, Cheng had all tried to use peripheral nerve grafts in different ways, yet only with rather feeble regeneration. One of the reasons for their failure, perhaps, was the lack of a good blood supply of the transplanted nerve graft in the environment of the spinal canal where the bony and ligamentous surrounding and the CSF were not conducive to re-vascularisation, thus leading to necrosis and fibrosis of the grafts. The use of vascularise nerve grafts (VNG) may therefore open up a new approach in spinal cord regeneration.The principal investigator had explored the use of VNG in spinal cord injury in the rat. A graft of the median and ulnar nerve of the upper limb was harvested with a long pedicle of blood vessl and was directed towards a defect of the spinal cord at the cervico-dorsal junction. Initially, a total transection of the cord was created, but all the animals died. Even with a hemi-transection model, 50% of the animal died unless very careful post-operative care was instituted. The subsequent study of the regeneration through the graft had to be carried out with the remaining intact half completely divided in order to show neurotransport and electrical conduction across the grafts. Extremely painstaking care and highly demanding technique was required. With such an amimal model, it was possible to show extraordinary good regeneration into the graft when compared to non-vascularised free nerve grafts (FNG).This animal model with a hemi-resection of the spinal cord, however, is open to all kinds of criticism. It will be ideal to develop an animal model where a VNG can be used to bridge a complete transection of the spinal cord.In trying to establish a VNG for a complete transection of the spinal cord, it is almost certain that the only feasible site for a complete cord transection in the animal has to be performed below the mid-thoracic level as a higher level will incur an extremely high mortality rate. In this area, vascularised nerve grafting post 2 major problems :-(1) Initial exploration showed that pedicled nerve graft from both the upper limb and the lower limb could not reach this area in the rat and rabbit.(2) If free vascularised grafts are used, the recipient blood vessels are too small for microvascular anatomosis even in the rat. |
|
List of Research Outputs |
|
Ahmed
S.K., Fung B.K.K., Ip W.Y. and Chow S.P., Enhancing The Versatility
Of Reverse Flow Sural Artery Neurocutaneous Flap, 7th Congress of Asian
Pacific Federaton of Societies for Surgery of the Hand, |
|
Ahmed S.K., Li T., Leung G., Fung B.K.K., Ip W.Y. and Chow S.P., Long Term Results Of Distal Radio Ulnar Joint Arthroplasty In Rheumatoid Patients, 7th Congress of Asian Pacific Federation of Societies for Surgery of the Hand, Hong Kong, 14-17 February 2008. |
|
Ahmed S.K., Li T., Leung G., Fung B.K.K., Ip W.Y. and Chow S.P., Synovectomy Around the Wrist - Rewarding Alternate To Preserve Joint Integrity In Rheumatoid Patients, 7th Congress of Asian Pacific Federation of Societies for Surgery of the Hand, Hong Kong, 14-17 February 2008. |
|
Ahmed S.K., Fung B.K.K., Ip W.Y., Fok M. and Chow S.P., The versatile reverse flow sural artery neurocutaneous flap: A case series and review of literature, Journal of Orthopaedic Surgery and Research. 2008, 3:15. |
|
Ahmed S.K., Fung B.K.K., Ip W.Y. and Chow S.P., Unicompartmental Knee Hemiarthroplasty Using Vascularized Fibula Transfer - 25 Years Follow Up, 7th Congress of Asian Pacific Federation of Societies for Surgery of the Hand, Hong Kong, 14-17 February 2008 . 2008. |
|
Cheung P.Y., Fung B.K.K., Ip W.Y. and Chow S.P., Occupational Repetitive
Strain Injuries In Hong Kong, |
|
Chow
S.P., Phalangeal fixation - Indications,
techniques and problems, AO Hand and Wrist Fracture Management Course, |
|
Chow
S.P., Principles of lag screws in hand
fractures, AO Hand Coure, |
|
Chow
S.P., The columnar theory of distal radius
fractures - Fragment specific fixation, AO Hand and Wrist Fracture
Management Course, |
|
Garg R., Ip W.Y., Chow S.P. and Fung B.K.K., Dynamic treatment for proximal phalangeal fracture of the hand, Journal of Orthopaedic Surgery. 2007, 15(2): 211-215. |
|
Garg R., Amer T., Ahmed S.K., Fung B.K.K., Ip W.Y. and Chow S.P., Sensate flap for bed sores: Between dream and reality: A cadaver dissection study, Journal of Orthopaedics. 2008, 5:2. |
|
Garg R., Fung B.K.K., Chow S.P. and Ip W.Y., Surgical management of radial head dislocation in quadriplegic cerebral palsy - a 5 year follow-up, Journal of Hand Surgery . 2007, 32E(6): 725-726. |
|
Gibson I., Chow S.P., Lam K.W., Lu W.W., NGAN H.W., Ip W.Y. and Chiu P.K.Y., The Development Of An
Artifical Finger Joint, In: Paulo Bartolo, Bopaya Bidanda, Bio-materials
And Prototyping Applications In Medicine. |
|
Ip W.Y., Chow S.P., Lam K.W., Gibson I., Ngan A.H.W., Lu W. and Chiu P.K.Y., A Novel Artificial Prosthetic Replacement For The Proximal Interphalangeal Joint Of The Hand - From Concept To Prototype, Australian Orthopaedic Association Continuing Orthopaedic Education Meeting . 2008. |
|
Lau
T.W., Leung K.L., Tu Y.K., Chew
W. and Chow S.P., Can
radiographic findings predict outcome of intra-articular distal radius
fractues? A prospective multicenter study, The 27th Hong Kong Orthopaedic
Association Annual Congress, |
|
Lau T.W., Leung K.L., Chan C.F. and Chow S.P., Minimally invasive plate osteosynthesis in the treatment of proximal humeral fracture, International Orthopaedics. 2007, 31: 657-664. |
|
Leung
K.L., Tu Y.K., Chew W.Y.C. and Chow
S.P., Comparison of external and percutaneous pin fixation with plate
fixation for intra-articular distal radial fractures: A randomized study , Journal
of Bone and Joint Surgery. 2008, |
|
Li T., Leung G., Chan R., Cheung N., Ahmed S.K., Fung B.K.K., Ip W.Y. and Chow S.P., Role Of Occupational Therapist In Rehabilitation Of Rheumatoid Wrist, 7th Congress of Asian Pacific Federation of Societies for Surgery of the Hand, Hong Kong, 14-17 February 2008. |
|
Researcher
: Chow W |
|
List of Research Outputs |
|
Chen C.K., Li Y.H., Chow W. and Luk K.D.K., The modified Sofield-Millar operation in osteogenesis imperfecta - a review of ten years experience, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Researcher
: Don AS |
|
List of Research Outputs |
|
Wong K., Don A.S., Chong C.S., Wong Y.W., Cheung K.M.C. and Luk K.D.K., Selection of fusion levels in adolescent idiopathic scoliosis using fulcrum bending prediction - a prospective study, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Researcher
: Fang D |
|
List of Research Outputs |
|
Fang
D., Chiu
P.K.Y., Tang W.M. and Fang C.,
Asian total hip system: Clinical and radiological results at 11 years, 15th
Triennial Congress of |
|
Fang D., Chiu P.K.Y., Tang W.M. and Fang C., Asian total hip system: clinical and radiological results at 11 years, Proceedings of the 15th Congress of Asia Pacific Orthopaedic Association, Seoul, Korea, September 9-13, 2007. 226. |
|
Li Z., Lu W.W., Chiu P.K.Y., Lam R.W.M., Tang B., Ngan A.H.W., Wong C.T., Fang D., Cheung K.M.C. and Luk K.D.K., Micro-architectural and nano-mechanical properties of trabecular bone with strontium treatment in large animal model of osteoporosis, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2007, 11: S80. |
|
Li Z., Lu W.W., Chiu P.K.Y., Lam R.W.M., Tang B., Ngan A.H.W., Wong C.T., Fang D., Cheung K.M.C. and Luk K.D.K., Micro-architectural and nano-mechanical properties of trabecular bone with strontium treatment in large animal model of osteoporosis, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Lu W.W., Li Z., Chiu P.K.Y., Lam R.W.M., Yang C., Xu B., Wong C.T., Fang D., Cheung K.M.C. and Luk K.D.K., Bone composition and mineral crystal structure after strontium treatment for osteoporosis in goat model, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2007, 11: S79. |
|
Lu W.W., Li Z., Chiu P.K.Y., Lam R.W.M., Yang C., Xu B., Wong C.T., Fang D., Cheung K.M.C. and Luk K.D.K., Bone composition and mineral crystal structure after strontium treatment for osteoporosis in goat model, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Lu W.W., Li Z., Chiu P.K.Y., Lam R.W.M., Cheung K.M.C., Fang D., Leong J.C.Y. and Luk K.D.K., Mineral Crystal Composition and Structure of New Bone after Strontium Treatment for Osteoporosis in Goat Model, 54th Annual Meeting of the Orthopaedic Research Society, San Francisco, USA. 2008, P966. |
|
Researcher
: Fung BKK |
|
List of Research Outputs |
|
Ahmed
S.K., Fung B.K.K., Ip W.Y. and Chow S.P., Enhancing The Versatility Of
Reverse Flow Sural Artery Neurocutaneous Flap, 7th Congress of Asian
Pacific Federaton of Societies for Surgery of the Hand, |
|
Ahmed S.K., Li T., Leung G., Fung B.K.K., Ip W.Y. and Chow S.P., Long Term Results Of Distal Radio Ulnar Joint Arthroplasty In Rheumatoid Patients, 7th Congress of Asian Pacific Federation of Societies for Surgery of the Hand, Hong Kong, 14-17 February 2008. |
|
Ahmed S.K., Li T., Leung G., Fung B.K.K., Ip W.Y. and Chow S.P., Synovectomy Around the Wrist - Rewarding Alternate To Preserve Joint Integrity In Rheumatoid Patients, 7th Congress of Asian Pacific Federation of Societies for Surgery of the Hand, Hong Kong, 14-17 February 2008. |
|
Ahmed S.K., Fung B.K.K., Ip W.Y., Fok M. and Chow S.P., The versatile reverse flow sural artery neurocutaneous flap: A case series and review of literature, Journal of Orthopaedic Surgery and Research. 2008, 3:15. |
|
Ahmed S.K., Fung B.K.K., Ip W.Y. and Chow S.P., Unicompartmental Knee Hemiarthroplasty Using Vascularized Fibula Transfer - 25 Years Follow Up, 7th Congress of Asian Pacific Federation of Societies for Surgery of the Hand, Hong Kong, 14-17 February 2008 . 2008. |
|
Cheung P.Y., Fung B.K.K., Ip W.Y. and Chow S.P., Occupational Repetitive Strain
Injuries In Hong Kong, |
|
Garg R., Ip W.Y., Chow S.P. and Fung B.K.K., Dynamic treatment for proximal phalangeal fracture of the hand, Journal of Orthopaedic Surgery. 2007, 15(2): 211-215. |
|
Garg R., Amer T., Ahmed S.K., Fung B.K.K., Ip W.Y. and Chow S.P., Sensate flap for bed sores: Between dream and reality: A cadaver dissection study, Journal of Orthopaedics. 2008, 5:2. |
|
Garg R., Fung B.K.K., Chow S.P. and Ip W.Y., Surgical management of radial head dislocation in quadriplegic cerebral palsy - a 5 year follow-up, Journal of Hand Surgery . 2007, 32E(6): 725-726. |
|
Li T., Leung G., Chan R., Cheung N., Ahmed S.K., Fung B.K.K., Ip W.Y. and Chow S.P., Role Of Occupational Therapist In Rehabilitation Of Rheumatoid Wrist, 7th Congress of Asian Pacific Federation of Societies for Surgery of the Hand, Hong Kong, 14-17 February 2008. |
|
Researcher
: Garg R |
|
List of Research Outputs |
|
Garg R., Amer T., Ahmed S.K., Fung B.K.K., Ip W.Y. and Chow S.P., Sensate flap for bed sores: Between dream and reality: A cadaver dissection study, Journal of Orthopaedics. 2008, 5:2. |
|
Garg R., Fung B.K.K., Chow S.P. and Ip W.Y., Surgical management of radial head dislocation in quadriplegic cerebral palsy - a 5 year follow-up, Journal of Hand Surgery . 2007, 32E(6): 725-726. |
|
Researcher
: Ho G |
|
List of Research Outputs |
|
Ho G., Leung Y.L., Chan D. and Cheung K.M.C., Effect of severity of intervertebral disc injury on mesenchymal stem cell-based regeneration, Connective Tissue Research. 2008, 49: 15-21. |
|
Researcher
: Hu Y |
|
Project Title: |
A Sensor Array Approach to Spatial Presentation on Surface Electromyography of Intra-muscular Pain Behaviour |
|
Investigator(s): |
Hu Y, Luk KDK |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
04/2006 |
|
Abstract: |
|
The objectives of this study are 1) to develop new methodology of myoelectric signal acquisition, decomposition and processing in sensor array sEMG for discovering and exploration of in-vivo functional physiology of muscle, 2) to characterise and compare the in-vivo motor unit firing behaviour and coordination processes corresponding to the actual pathophysiological status; and 3) to investigate the pain behaviour and electrophysiology of neuromuscular system in healthy, myopathic, spinal cord compression, and nerve root compression condition. Pain is the most common clinical symptom in various pathological conditions, which usually affects neuromuscular electrophysiological patterns. However, the pathomechanism of the effect of pain on neuromuscular activation potential distribution and their coordination behavior are still unclear. The key issus of this study is to find various myoelectrical activity patterns of the insulted muscle area, which will establish a reliable model to simulate the pain effcts on muscle activation and muscle contraction behaviour. |
|
Project Title: |
Novel method for fast extraction and auto-recognition of somatosensory evoked potentials |
|
Investigator(s): |
Hu Y, Luk KDK, |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
01/2007 |
|
Abstract: |
|
(1) Purpose of investigation:
Intraoperative spinal cord monitoring can significantly minimize the risks of
iatrogenic injury to spinal cord during spinal surgery, neurosurgery and
aortic surgery. Somatosensory evoked potential (SEP) is the most popular
technique currently being used in the operating room. The ensemble averaging
method (EA) is the only practical method to extract SEP, but it will considerably
lengthen the surgical time and hinder the surgical procedures, and more
importantly, it cannot provide the spine surgeon with a timely warning of the
eminent danger of cord injury. This motivates us to study and develop a new
and improved method for fast extraction and automatic recognition of SEP.(2)
Key issues and major problems: The main problem in SEP monitoring is its
extremely low signal to noise ratio (SNR) and variability in its signal
waveform. The EA method is used to extract SEP from background noise, but it
is time-consuming. Moreover, the noisy waveform makes the auto-recognition of
abnormal changes in SEP a difficult task. Sometimes, latency/amplitude
measurement based on time-domain SEP waveform is highly variable.(3)
Objectives and Possible outcomes: This project has 3 main objectives: i) To
study and develop a signal processing technique for improving the SNR of SEP
signals. We shall study and apply a multi-adaptive filter in combination with
a novel data-reusing non-linear method based on radial basis function neural
network (RBFNN) for improving the SNR of SEP signals. (4) ii) To study and
develop a fast extraction method for separating the SEP signal from other
interference based on multi-channel blind source separation. The use of a multi-adaptive
filter can improve the SNR of SEP signals, but it may not be sufficient to
obtain a reliable SEP signal by a single trial. The multi-channel blind
source separation (BSS) will be used to enhance the performance of the
algorithm so that a more reliable and reproducible SEP can be obtained from
every single trial. Moreover, the time-frequency feature of SEP will be
investigated to establish a time-frequency model for auto-classification and
identification of SEP waveform. (5) iii) To investigate and develop an
auto-recognition method based on time-frequency analysis of SEP. The
developed fast extraction and auto-recognition methods will be applied to
clinical and animal experiments and the specificity and sensitivity can be
then evaluated. (6) Long-term impact, relevance, significance and value: The
findings of this research will contribute to the further development of fast
and reliable techniques for SEP monitoring. The ultimate goal is to provide
safer and more reliable monitoring, which is more easy to carry out during
surgery. In addition, the results of this research would benefit the further
development in SEP diagnosis of neuromuscular disorders. On the engineering
perspective, the signal processing algorithms and results so developed will
have considerable impact on the theory and practice of multi-channel signal
processing, especially in neural engineering and electroencephalograph
extraction. Last but not least, the future application of this study can be
developed into a product with economical benefit for |
|
Project Title: |
7T fMRI study on a new rat model with chronic and progressive spinal cord compression |
|
Investigator(s): |
Hu Y, Luk KDK, Wu EX |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
03/2007 |
|
Abstract: |
|
To develop a new material based on water-absorbing polyurethane elastomer encased by sustained-release membrane, which can expand it volume under well control; to establish a new animal model of cervical spondylotic myelopathy with chronic and progressive compression to the spianl cord; to testify the feasibility and reliability of this new animal model by functional MRI, radiological and electrophysiological examination. Cervical spondylotic myelopathy (CSM) is a common spinal discorder caused by degeneration of the cervical spine, impairs motor and sensory functions insidiously and progressively. However, the exact pathophysiology and precise mechanisms of the disease process remains to be elucidated. The key issue and problem addressed here is the difficulty to reproduce the chronic spinal cord compress on animal model. This study is to establish a new animal modle with progressive compression on the cord in a controllable duration and designed profile. |
|
List of Research Outputs |
|
Chu Y.W., McManus A.M. and Hu Y., Short-Duration Patterning Of Physical Activity And Biomechanical Walking Efficiency In Lean And Overweight Children, The XXIV Pediatric Work Physiology Meeting Children And Exercise, 5-9 September 2007, Estonia. 2007. |
|
Chu Y.W., McManus A.M. and Hu Y., Short-duration patterning of physical activity and biomechanical efficiency., In: Jürimäe T., Armstrong N., Jürimäe J., Children and Exercise XXIV.. 2008, 154-157. |
|
Chu Y.W., McManus A.M. and Hu Y., Short-duration patterning of physical activity and biomechanical walking efficiency in lean and overweight children., Short-duration patterning of physical activity and biomechanical walking efficiency in lean and overweight children.. 2007. |
|
Chu
Y.W., McManus A.M. and Hu Y., The Young Investigator Award
(Short-duration Patterning Of Physical Activity And Biomechanical Walking
Efficiency In Lean And Overweight Children), The 24th Pediatric Work
Physiology Meeting (Children And Exercise) XXIV, |
|
Hu Y., Clinical Guideline of Intraoperative Spinal cord Monitoring in Scoliosis Surgery, The 3rd International Congress of Spine Deformity and NonFusion techniques (SDN), Shanghai China 2008 . 第三届上海国际脊柱畸形与脊柱非融合技术大会, 2008. |
|
Hu Y., Leung H.B., Lu W.W. and Luk K.D.K., Histological and electrophysiological changes of the Paraspinal Muscle after Spinal Fusion: an Experimental Study., Spine. 2008, 33: 1418-22. |
|
Hu Y., Ding Y., Yuan D., Wong Y.W., Cheung K.M.C. and Luk K.D.K., Prognostic value of somatosensory-evoked potentials in the surgical management of cervical spondylotic myelopathy, Spine. 2008, 33: E305-10. |
|
Hu
Y., Mak
J.N.F., Wong Y.W., Leong J.C.Y. and Luk K.D.K., Quality of life of traumatic
spinal cord injured patients in |
|
Hu
Y., Jiang F. and Luk K.D.K., Time-frequency Feature of
Intraoperative Somatosensory Evoked Potential Signals., In: , Annual
International Conference of the IEEE Engineering in Medicine and Biology
Society. |
|
Li Y.Z., Xu T., Wang L.Q. and Hu Y., fMRI-constrained source
analysis of visual P |
|
Liu H., Hu Y., Chang C. and Luk K.D.K., Fast extraction of somatosensory evoked potential based on second order blind identification, IEEE EMBS Annual Conference (EMBS2007). 2007. |
|
Luk K.D.K., Mak J.N.F. and Hu Y., Application of surface electromyography in low back pain assessment, Fifth SICOT/SIROT Annual International Conference, Marrakech, Morocco, August 29 - September 1, 2007. |
|
Ng M.C., Ho J.T., Ho S.L., Lee R., Li G., Cheng T.S., Song Y., Ho W.L., Fong C.Y., Mak W., Chan K.H., Li L.S.W., Luk K.D.K., Hu Y., Ramsden D.B. and Leong Fung L.L.Y., Abnormal diffusion tensor in nonsymptomatic familial amyotrophic lateral sclerosis with a causative superoxide dismutase 1 mutation., J Magn Reson Imaging. . 2008, 27(1): 8-13. |
|
Ng M.C., Wu E.X., Lau H.F., Hu Y., Lam E.Y.M. and Luk K.D.K., Cervical spinal cord BOLD fMRI study: Modulation of functional activation by dexterity of dominant and non-dominant hands., Neuroimage. 831, 2008, 39: 825. |
|
Ng M.C., Hua J., van Zijl P., Yang E., Hu Y., Luk K.D.K. and Lam E.Y.M., Magnetization Transfer (MT) asymmetry in human cervical spinal cord, International Society of Magnetic Resonance in Medicine Annual Meeting. 2008, 3404. |
|
Shen
C., Liu H., Xie X., Luk K.D.K. and Hu Y., Selection of floating-point
or fixed-point For Adaptive Noise Canceller In Somatosensory Evoked Potential
Measurement., Annual International Conference of the IEEE Engineering in
Medicine and Biology Society. |
|
Researcher
: Hung SC |
|
List of Research Outputs |
|
Leung Y.L., Hung S.C., Li L.C., Wu E.X., Luk K.D.K., Chan D. and Cheung K.M.C., Age-related degeneration of lumbar intervertebral disc in rabbit reveal by deuterium oxide-assisted MRI, Best Poster Award, World Forum for Spine Research - the intervertebral disc, first Japanese meeting, Kyoto, Japan, January 23-26, 2008 . 2008. |
|
Leung Y.L., Hung S.C., Li L.C., Wu E.X. and Luk K.D.K., Age-related degeneration of lumbar intervertebral discs in rabbits revealed by Deuterium Oxide-assisted MRI, Best General Poster Award, World Forum for Spine Research - the intervertebral disc, first Japanese meeting, Kyoto, Japan, January 23-26, 2008. 2008. |
|
Leung Y.L., Hung S.C., Chan Li L.C., Wu E.X., Luk K.D.K., Chan D. and Cheung K.M.C., Age-related degeneration of lumbar intervertebral discs in rabbits revealed by deuterium oxide-assisted MRI, World Forum for Spine Research - the Intervertebral Disc. 2008. |
|
Leung Y.L., Hung S.C., Chan Li L.C., Wu E.X., Luk K.D.K., Chan D. and Cheung K.M.C., Aged-related degeneration of lumbar intervertebral discs in rabbits revealed by deuterium oxide-assisted MRI, World Forum for Spine Research - The Interveretegral Disc, First Japanese Meeting, Kyoto, Japan, January 23-26, 2008. |
|
Luk K.D.K., Leung Y.L., Hung S.C., Tsui Y.K., Lee M.K., Chan Li L.C., Lo G.G., Masuda K., Wu E.X. and Chan D., Allogeneic mesenchymal stem cell transplantation into the intervertebral disc; effect of severity of degeneration and cell number on regeneration, 15th Triennial Congress of Asia Pacific Orthopaedic Association, Seoul, Korea, September 9-13, 2007. |
|
Project Title: |
Study on wrist problems |
|
Investigator(s): |
Ip WY, Chow SP |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Other Funding Scheme |
|
Start Date: |
01/1996 |
|
Abstract: |
|
To study the clinical problems of chronic wrist pain. The individual specific clinical problems including sequalae of fracture distal radius, carpal instability, distal radio-ulnar joint problems, triangular fibrocartilage complex lesions and ulnar abatment syndromes would be studied in details. The objectives are to find the best treatment methods and to improve the functional results. |
|
Project Title: |
The study of work related hand injuries in Hong Kong |
|
Investigator(s): |
Ip WY, Chow SP |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Occupational Safety and Health Council - Research Grant Projects |
|
Start Date: |
01/1998 |
|
Abstract: |
|
To study the epidemiology of severe hand injuries which are work related in Hong Kong Island; to suggest more accurate prognostic factors and more reasonable disability assessment system of hand injury; to give suggestions in industrial safety; to improve management of severe hand injuries; to minimise the social cost of severe hand injuries. |
|
Project Title: |
Use of bio-corrodible alloys for tissue engineering |
|
Investigator(s): |
|
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
10/2006 |
|
Abstract: |
|
The objective of this small project is to investigate the feasibility and the difficulties in the use of bio-corrodible alloys and their composites, particularly magnesium alloys and their composites, as a temporary implant material in the body when used in a significant amount, to facilitate the repairing of body tissues.Animal work will determine the "in vivo" compatibility of such biomaterials, and cell culture will suggest whether such alloys and composites can promote the growth of cells other than osteoblasts. Investigation on composites will suggest the research direction in the reduction or elimination of the gas evolved from the alloys and trapped under tissues. |
|
List of Research Outputs |
|
Ahmed
S.K., Fung B.K.K., Ip W.Y. and Chow S.P., Enhancing The Versatility Of
Reverse Flow Sural Artery Neurocutaneous Flap, 7th Congress of Asian
Pacific Federaton of Societies for Surgery of the Hand, |
|
Ahmed S.K., Li T., Leung G., Fung B.K.K., Ip W.Y. and Chow S.P., Long Term Results Of Distal Radio Ulnar Joint Arthroplasty In Rheumatoid Patients, 7th Congress of Asian Pacific Federation of Societies for Surgery of the Hand, Hong Kong, 14-17 February 2008. |
|
Ahmed S.K., Li T., Leung G., Fung B.K.K., Ip W.Y. and Chow S.P., Synovectomy Around the Wrist - Rewarding Alternate To Preserve Joint Integrity In Rheumatoid Patients, 7th Congress of Asian Pacific Federation of Societies for Surgery of the Hand, Hong Kong, 14-17 February 2008. |
|
Ahmed S.K., Fung B.K.K., Ip W.Y., Fok M. and Chow S.P., The versatile reverse flow sural artery neurocutaneous flap: A case series and review of literature, Journal of Orthopaedic Surgery and Research. 2008, 3:15. |
|
Ahmed S.K., Fung B.K.K., Ip W.Y. and Chow S.P., Unicompartmental Knee Hemiarthroplasty Using Vascularized Fibula Transfer - 25 Years Follow Up, 7th Congress of Asian Pacific Federation of Societies for Surgery of the Hand, Hong Kong, 14-17 February 2008 . 2008. |
|
Cheung P.Y., Fung B.K.K., Ip W.Y. and Chow S.P., Occupational Repetitive Strain
Injuries In Hong Kong, |
|
Garg R., Ip W.Y., Chow S.P. and Fung B.K.K., Dynamic treatment for proximal phalangeal fracture of the hand, Journal of Orthopaedic Surgery. 2007, 15(2): 211-215. |
|
Garg R., Amer T., Ahmed S.K., Fung B.K.K., Ip W.Y. and Chow S.P., Sensate flap for bed sores: Between dream and reality: A cadaver dissection study, Journal of Orthopaedics. 2008, 5:2. |
|
Garg R., Fung B.K.K., Chow S.P. and Ip W.Y., Surgical management of radial head dislocation in quadriplegic cerebral palsy - a 5 year follow-up, Journal of Hand Surgery . 2007, 32E(6): 725-726. |
|
Gibson I., Chow S.P., Lam K.W., Lu W.W., NGAN H.W., Ip W.Y. and Chiu P.K.Y., The Development Of An
Artifical Finger Joint, In: Paulo Bartolo, Bopaya Bidanda, Bio-materials
And Prototyping Applications In Medicine. |
|
HUI L.F., Fong D.Y.T., YAM H.F. and Ip W.Y., Translation And Validation Of The Chinese Diabetic Foot Ulcer Scale- Short Form, Patient. 2008, 1(2): 137-145. |
|
Hui L.F., Fong D.Y.T., Yam M. and Ip W.Y., Psychometric Evaluation of the Chinese Diabetic Foot Ulcer Scale - Short Form, Asian Chinese Quality of Life Conference. 2008. |
|
Ip
W.Y., A Local Experience Of Upper Limb
Surgery For Tetraplegia In |
|
Ip W.Y., Chow S.P., Lam K.W., Gibson I., Ngan A.H.W., Lu W. and Chiu P.K.Y., A Novel Artificial Prosthetic Replacement For The Proximal Interphalangeal Joint Of The Hand - From Concept To Prototype, Australian Orthopaedic Association Continuing Orthopaedic Education Meeting . 2008. |
|
Ip W.Y., Application Of Resorbable Polymer In Guided Bone Regeneration, International Conference In Hand Biomechanics. 2007. |
|
Ip
W.Y., Diabetic foot care - Hong Kong
experience, The 4th Asia Pacific Conference on Diabetic Limb Problems, |
|
Ip
W.Y., Hand Fractures, |
|
Ip
W.Y. and Yuen
C.K., Implant for Tissue |
|
Ip
W.Y., Novel Artificial Finger Joint
Development, |
|
Ip
W.Y., Novel artificial finger joint
development, 5th Hong Kong International Orthopaedic Forum: "The New
Frontiers", |
|
Ip W.Y., Phalangeal Fracture Treatment, Asian Pacific Federation For Societies For Surgery Of The Hand. 2008. |
|
Ip W.Y., Surgical Techniques For Flexor Tendon Repair, Chung Hand And Upper Extremity Reconstruction. 2008. |
|
Leung Y.F., Ip S.P., Wong A. and Ip W.Y., Trans-triquetral Dorsal Perilunate Fracture Dislocation, Journal Of Hand Surgery Eur Volume. 2007, 32(6): 647-8. |
|
Li T., Leung G., Chan R., Cheung N., Ahmed S.K., Fung B.K.K., Ip W.Y. and Chow S.P., Role Of Occupational Therapist In Rehabilitation Of Rheumatoid Wrist, 7th Congress of Asian Pacific Federation of Societies for Surgery of the Hand, Hong Kong, 14-17 February 2008. |
|
Yuen C.K. and Ip W.Y., Biodegradable Magnesium Alloys For Tissue Engineering And Other Biological Applications: Unexpected Findings From Mouse Model , 2008 Annual Termis-eu Meeting. 2008. |
|
Yuen C.K. and Ip W.Y., Findings From An Accelerated In Vivo Corrosion Model Of Magnesium, Nature Proceedings. 2008, 10: 1833. |
|
Yuen C.K. and Ip W.Y., Resorbable Metallic Implant: Findings From An Animal Model, Advanced Materials Research. 2008, 47-50: 604-607. |
|
Yuen
C.K. and Ip W.Y.,
Resorbable Metallic Implant: Finginds From An Animal Model, In: CK |
|
Zhou W., Lee S.H., Wang M., Cheung W.L. and Ip W.Y., Selective Laser Sintering Of Porous Tissue Engineering Scaffolds From Poly(l-lactide)/carbonated Hydroxyapatite Nanocomposite Microspheres, Journal Material Sci: Mater Med. 2007, 19: 2535-2540. |
|
Zhou
W., Wang M., Cheung W.L., Yuen C.K. and Ip W.Y., Selective laser sintered
Meso-porous PLLA and PLLA/CHAp nanocomposite scaffolds for bone tissue
engineering, Proceedings of the 8th World Biomaterials Congress. |
|
Researcher
: Jim JJT |
|
List of Research Outputs |
|
Aladin
Kaderbatcha D.M., Cheung K.M.C., Chan D., Yee A.F.Y., Jim J.J.T., Luk K.D.K. and Lu W.W., Expression of the Trp2 allele
of COL |
|
Researcher
: Lam KO |
|
List of Research Outputs |
|
Lam
K.O., Yeung
K.W.K., Chan Y.L., Wu S.L., Liu
X.M., Chung C.Y., |
|
Liu X.M., Wu S.L., |
|
Wong
H.M., Yeung K.W.K., Lam K.O., |
|
Wu S.L., Liu X.M., Chan Y.L., Chung C.Y., |
|
Yeung
K.W.K., Chan Y.L., Lam K.O., Liu X.M., Wu S.L., Liu
X.Y., Chung C.Y., Lu W.W., Chan D., Luk K.D.K., |
|
Researcher
: Lam KW |
|
List of Research Outputs |
|
Gibson I., Chow S.P., Lam K.W., Lu W.W., NGAN H.W., Ip W.Y. and Chiu P.K.Y., The Development Of An
Artifical Finger Joint, In: Paulo Bartolo, Bopaya Bidanda, Bio-materials
And Prototyping Applications In Medicine. |
|
Ip W.Y., Chow S.P., Lam K.W., Gibson I., Ngan A.H.W., Lu W. and Chiu P.K.Y., A Novel Artificial Prosthetic Replacement For The Proximal Interphalangeal Joint Of The Hand - From Concept To Prototype, Australian Orthopaedic Association Continuing Orthopaedic Education Meeting . 2008. |
|
Researcher
: Lam KW |
|
List of Research Outputs |
|
Gibson I., Chow S.P., Lam K.W., Lu W.W., NGAN H.W., Ip W.Y. and Chiu P.K.Y., The Development Of An
Artifical Finger Joint, In: Paulo Bartolo, Bopaya Bidanda, Bio-materials
And Prototyping Applications In Medicine. |
|
Ip W.Y., Chow S.P., Lam K.W., Gibson I., Ngan A.H.W., Lu W. and Chiu P.K.Y., A Novel Artificial Prosthetic Replacement For The Proximal Interphalangeal Joint Of The Hand - From Concept To Prototype, Australian Orthopaedic Association Continuing Orthopaedic Education Meeting . 2008. |
|
Researcher
: Lam RWM |
|
List of Research Outputs |
|
Lam R.W.M., Wong C.T., Li Z., Luk K.D.K., Chan W.K., Yang C., Chiu P.K.Y., Xu B. and Lu W.W., Solvothermal synthesis of strontium phosphate chloride nanowire, Journal of Cystal Growth. 2007, 306: 129-134. |
|
Li Z., Yang C., Lu W.W., Xu B., Lam R.W.M., Ni G., Abbah S.A., Yang F., Cheung K.M.C. and Luk K.D.K., Characteristics and mechanical properties of acrylolpamidronate-treated strontium containing bioactive bone cement, J Biomed Mater Res B Appl Biomater. 2007, 83(2): 464-71. |
|
Li Z., Lu W.W., Lam R.W.M., Chiu P.K.Y., Cheung K.M.C. and Luk K.D.K., Micro-architectural and Nano-mechanical Properties of Trabecular Bone with Strontium Treatment in Osteoporotic Goats, 9th Regional Osteoporosis Conference, Hong Kong. 2008. |
|
Li Z., Lu W.W., Chiu P.K.Y., Lam R.W.M., Tang B., Ngan A.H.W., Wong C.T., Fang D., Cheung K.M.C. and Luk K.D.K., Micro-architectural and nano-mechanical properties of trabecular bone with strontium treatment in large animal model of osteoporosis, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2007, 11: S80. |
|
Li Z., Lu W.W., Chiu P.K.Y., Lam R.W.M., Tang B., Ngan A.H.W., Wong C.T., Fang D., Cheung K.M.C. and Luk K.D.K., Micro-architectural and nano-mechanical properties of trabecular bone with strontium treatment in large animal model of osteoporosis, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Li Z., Lu W.W., Chiu P.K.Y., Lam R.W.M., Cheung K.M.C., Tang B., Ngan A.H.W. and Luk K.D.K., Micro-architecture and Nano-mechanics of Lumbar Vertebra with Strontium Treatment in Large Animal Model of Osteoporosis, 54th Annual Meeting of the Orthopaedic Research Society, San Francisco, USA. 2008, P276. |
|
Lu W.W., Li Z., Chiu P.K.Y., Lam R.W.M., Yang C., Xu B., Wong C.T., Fang D., Cheung K.M.C. and Luk K.D.K., Bone composition and mineral crystal structure after strontium treatment for osteoporosis in goat model, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2007, 11: S79. |
|
Lu W.W., Li Z., Chiu P.K.Y., Lam R.W.M., Yang C., Xu B., Wong C.T., Fang D., Cheung K.M.C. and Luk K.D.K., Bone composition and mineral crystal structure after strontium treatment for osteoporosis in goat model, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Lu W.W., Li Z., Chiu P.K.Y., Lam R.W.M., Cheung K.M.C., Fang D., Leong J.C.Y. and Luk K.D.K., Mineral Crystal Composition and Structure of New Bone after Strontium Treatment for Osteoporosis in Goat Model, 54th Annual Meeting of the Orthopaedic Research Society, San Francisco, USA. 2008, P966. |
|
Lu W.W., Peng S.L., Zhou G., Luk K.D.K., Li Z., Wong C.T., Lam R.W.M. and Cheung K.M.C., Strontium promotes osteogenic differentiation and inhibits the osteoclastogenic potentials in murine mesenchymal stem cells, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Pan
H., Li Z., Lam R.W.M., Wong C.T. and Lu W.W., Solubility study of 10% Sr-Hap
and the effect of strontium by solid titration, 1st asian biomaterials
congress, |
|
Zheng Z.M., Luk K.D.K., Kuang G.M., Li Z., Lin J., Lam R.W.M., Cheung K.M.C. and Lu W.W., Vertebral augmentation with a novel vessel-x bone void filling container system and ioactive bone cement, Spine. 2007, 32(19): 2076-2082. |
|
Researcher
: Lam WMR |
|
List of Research Outputs |
|
Lam W.M.R., Wong C.T., Li Z., Luk K.D.K., Chan W.K., Yang C., Chiu P.K.Y., Xu B. and Lu W.W., Solvothermal synthesis of strontium phosphate chloride nanowire., Journal of Crystal Growth. 2007, 306 (1): 129-134. |
|
Researcher
: Lau TW |
|
List of Research Outputs |
|
Chan C.F., Lau T.W. and Leung K.L., Clinical outcome of minimally invasive plate osteosynthesis in the management of fractures of distal tibia, The 27th Hong Kong Orthopaedic Association Annual Congress, Hong Kong, 17-18 November 2007. |
|
Lau
T.W., Leung
K.L., Tu Y.K., Chew W. and Chow S.P.,
Can radiographic findings predict outcome of intra-articular distal radius
fractues? A prospective multicenter study, The 27th Hong Kong Orthopaedic
Association Annual Congress, |
|
Lau T.W., Leung K.L., Chan C.F. and Chow S.P., Minimally invasive plate osteosynthesis in the treatment of proximal humeral fracture, International Orthopaedics. 2007, 31: 657-664. |
|
Researcher
: Lee MK |
|
List of Research Outputs |
|
Luk K.D.K., Leung Y.L., Hung S.C., Tsui Y.K., Lee M.K., Chan Li L.C., Lo G.G., Masuda K., Wu E.X. and Chan D., Allogeneic mesenchymal stem cell transplantation into the intervertebral disc; effect of severity of degeneration and cell number on regeneration, 15th Triennial Congress of Asia Pacific Orthopaedic Association, Seoul, Korea, September 9-13, 2007. |
|
Researcher
: Leong JCY |
|
List of Research Outputs |
|
Abbah S.A., Lu W.W., Chan D., Cheung K.M.C., Zhao F., Li Z., Leong J.C.Y. and Luk K.D.K., Osteogenic behavior of alginate encapsulated bone marrow stromal cells: an in vitro study, J Mater Sci Mater Med. 2008, 19(5): 2113-9. |
|
Cheung K.M.C., Song Y., Ho D.W.H., Poon S.C.S., Chiba K., Kawaguchi Y., Hirose Y., Alini M., Grad S., Yee A.F.Y., Leong J.C.Y., Luk K.D.K., Yip S.P., Karppinen J., Cheah K.S.E., Sham P.C., Ikegawa S. and Chan D., Association of the asporin D14 allele with lumbar disc degeneration, Spineweek 2008, Geneva, Switzerland, May 26-31, 2008. |
|
Ho D.W.H., Cheung K.M.C., Chan D., Karppinene J., Yip S.P., Ott J., Luk K.D.K., Leong J.C.Y., Cheah K.S.E., Sham P.C. and Song Y., Linkage Analysis on Familial Early-onset Degenerative Disc Disease, 12th Research Postgraduate Symposium, December 12 & 14, 2007 . 2007. |
|
Hu Y.,
Mak J.N.F., Wong Y.W., Leong J.C.Y. and Luk K.D.K., Quality of life of traumatic
spinal cord injured patients in |
|
Kao P.Y.P., Chan D., Cheung K.M.C., Ho D.W.H., Karppinen J., Leong J.C.Y., Luk K.D.K., Yip S.P., Cheah K.S.E., Song Y., Sham P.C. and Sham P.C., Genome-wide association study of degenerative disc disease, Spineweek 2008, Geneva, Switzerland, May 26-31, 2008. |
|
Leong J.C.Y., Li Z. and Lu W.W., Development and clinical trial of a novel bioactive bone cement, Frontiers of Medicine in China. 2008, 2(2): 117-26. |
|
Lie C.W.H., Cheung K.M.C., Fan B.J., Karpinnen J., Leong J.C.Y. and Luk K.D.K., Can age-related intervertebral disc changes be differentiated from degenerative disc disease, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Lu W.W., Li Z., Chiu P.K.Y., Lam R.W.M., Cheung K.M.C., Fang D., Leong J.C.Y. and Luk K.D.K., Mineral Crystal Composition and Structure of New Bone after Strontium Treatment for Osteoporosis in Goat Model, 54th Annual Meeting of the Orthopaedic Research Society, San Francisco, USA. 2008, P966. |
|
Song Y., Ho D.W.H., Karppinen J., Kao P.Y.P., Fan B.J., Luk K.D.K., Yip S.P., Leong J.C.Y., Cheah K.S.E., Sham P.C., Chan D. and Cheung K.M.C., Association between promoter-1607 polymorphism of MMP1 and lumbar disc disease in Southern Chinese, BMC Medical Genetics. 2008, 9(1): 38. |
|
Song Y., Cheung K.M.C., Ho D.W.H., Poon S.C.S., Chiba K., Kawaguchi Y., Hirose Y., Alini M., Grad S., Yee A.F.Y., Leong J.C.Y., Luk K.D.K., Yip S.P., Karppinen J., Cheah K.S.E., Sham P.C., Ikegawa S. and Chan D., Association of the asporin D14 allele with lumbar disc degeneration in Asians, American Journal of Human Genetics. 2008, 82(3): 744-747. |
|
Wong K., Cheung K.M.C., Karpinnen J., Fan B.J., Leong J.C.Y. and Luk K.D.K., Relationship between magnetic
resonance imaging changes of the lumbar spine and low back pain: a magnetic
resonance imaging study of 1043 population-based subjects, 27th Annual
Congress of the Hong Kong Orthopaedic Association, |
|
Wong Y.W., Leong J.C.Y. and Luk K.D.K., Direct internal kyphectomy for severe angular tuberculous kyphosis, Clinical Orthopaedics and Related Research. 2007, 460: 124-129. |
|
Researcher
: Leung HB |
|
List of Research Outputs |
|
Hu Y., Leung H.B., Lu W.W. and Luk K.D.K., Histological and electrophysiological changes of the Paraspinal Muscle after Spinal Fusion: an Experimental Study., Spine. 2008, 33: 1418-22. |
|
Researcher
: Leung KL |
|
List of Research Outputs |
|
Chan C.F., Lau T.W. and Leung K.L., Clinical outcome of minimally invasive plate osteosynthesis in the management of fractures of distal tibia, The 27th Hong Kong Orthopaedic Association Annual Congress, Hong Kong, 17-18 November 2007. |
|
Lau
T.W., Leung K.L., Tu Y.K.,
Chew W. and Chow S.P., Can
radiographic findings predict outcome of intra-articular distal radius
fractues? A prospective multicenter study, The 27th Hong Kong Orthopaedic
Association Annual Congress, |
|
Lau T.W., Leung K.L., Chan C.F. and Chow S.P., Minimally invasive plate osteosynthesis in the treatment of proximal humeral fracture, International Orthopaedics. 2007, 31: 657-664. |
|
Leung
K.L., AO development and TK: experience and
development - pelvis , The 2nd AOAA Asian Chapter Symposium, |
|
Leung K.L., Anatomical considerations for screw placement in acetabulum, AO Pelvic Course, Davos, Switzerland, 1-6 December 2007. |
|
Leung K.L., Bone - Biological response to injury, AO Course, Principles of Operative Fracture Management, Xian, China, 26-28 June 2008. |
|
Leung
K.L., Calcaneal and talus fractures, AO
Advances Course for Surgeons, |
|
Leung
K.L., Calcaneus fractures, AO Combined
Courses, Advances in operative fracture management, |
|
Leung
K.L., Tu Y.K., Chew W.Y.C. and Chow S.P., Comparison of external and
percutaneous pin fixation with plate fixation for intra-articular distal
radial fractures: A randomized study , Journal of Bone and Joint Surgery.
2008, |
|
Leung
K.L., Complication of minimally invasive
plate fixation in distal tibial fractures, 15th Triennial Congress of Asia
Pacific Orthopaedic Association, |
|
Leung
K.L., Complications - incidence and
management, AO Combined Courses, Pelvic course, |
|
Leung K.L., Consulting Editorial Committee member since May 2008, Chinese Journal of Reparative and Reconstructive Surgery. 2008. |
|
Leung
K.L., Distal radius fracture, AO Advances
Course for Surgeons, |
|
Leung
K.L., Distal radius fractures in the elderly,
AO Course in Geriatric Fracture Management, |
|
Leung K.L., Early complications and prevention in acetabular fracture surgery, AO Pelvic Course, Davos, Switzerland, 1-6 December 2007. |
|
Leung K.L., Forearm shaft fractures - Strategies and approaches, AO Combined Courses, Advances in operative fracture management, Kobe, Japan, 21-23 February 2008. |
|
Leung
K.L., Ilizarov frame for nonunions, AO
Masters Course, |
|
Leung
K.L., Infection after osteosynthesis, AO
Course, Principles of Operative Fracture Management, Xian, |
|
Leung
K.L., Internal fixation of pelvic fractures:
minimally invasive approaches, The 58th Philippine Orthopaedic Association
Annual Congress, |
|
Leung
K.L., Intertrochanteric fracture: choice of
implant, AO Course in Geriatric Fracture Management, |
|
Leung
K.L., Intertrochanteric fracture: selecting
the proper implant?, The 58th Philippine Orthopaedic Association Annual
Congress, |
|
Leung
K.L., Locked compression plate - why and what
for, AO Course, Principles of Operative Fracture Management, Xian, |
|
Leung
K.L., New development in implant: Plates and
screws, 5th Hong Kong International Orthopaedic Forum: "The New
Frontiers", |
|
Leung K.L., New development in pelvic and acetabular surgery, The 2nd AOAA Asian Chapter Symposium, Jeju, Korea, 3-6 October 2007. |
|
Leung
K.L., Open fractures, AO Advances Course
for Surgeons, |
|
Leung
K.L., Osteoporotic pelvic fracture, 15th
Triennial Congress of Asia Pacific Orthopaedic Association, |
|
Leung
K.L., Pelvic fractures in the elderly, AO
Course in Geriatric Fracture Management, |
|
Leung
K.L., Pilon fracture, The 58th Philippine
Orthopaedic Association Annual Congress, |
|
Leung
K.L., Plate fixation of tibial shaft
fractures, The Second International Congress of Chinese Orthopaedic
Association, |
|
Leung K.L., Principles of open fracture management, AO Course, Principles of Operative Fracture Management, Xian, China, 26-28 June 2008 . 2008. |
|
Leung
K.L., Principles of treatment of articular
fractures, AO Course, Principles of Operative Fracture Management, Xian, |
|
Leung
K.L., Proximal tibial fractures, AO
Advances Course for Surgeons, |
|
Leung
K.L., Screw and lag screw principles, AO
Course, Principles of Operative Fracture Management, Xian, |
|
Leung
K.L., The internal fixator (LCP), AO ORP
Principles Course, |
|
Leung K.L., Tibial head fractures - Strategies and approaches, AO Combined Courses, Advances in operative fracture management, Kobe, Japan, 21-23 February 2008. |
|
Leung
K.L., Tibial shaft fractures, AO Advances
Course for Surgeons, |
|
Leung
K.L., Volar approach in distal radius
fractures, 1st AO Asia Pacific LCP Experts Seminar, |
|
Yeung
Y. and Leung K.L.,
Surgical treatment of unstable pertrochanteric fracture with proximal femoral
nail: Report of a new radiological complication and its implication in
Chinese hip, The 27th Hong Kong Orthopaedic Association Annual Congress, |
|
Researcher
: Leung YL |
|
Project Title: |
Molecular identity of nucleus pulposus cells in intervertebral disc |
|
Investigator(s): |
Leung YL, Cheung KMC, Chan D |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
12/2005 |
|
Abstract: |
|
1) Introduction: Low back pain has been a
major focus in clinical practice. It represents a world-wide health problem
of which about 70-80% population will experience low back pain in their
lifetime [1,6]. Intervertebral disc degeneration has been suggested to
associate with low back pain and sciatica and is thought to have multi-factorial
causes. Previous study in human indicated that 90% of people will develop
intervertebral disc degeneration above the age of 50. However, whether the
degeneration is caused by natural aging or other unknown pathological
conditions is still not clear [2]. Intervertebral discs (IVD) are avascular
fibrocartilagenous structures between the vertebral bodies of the spine which
function to articulate the spinal motion and are subject to high mechanical
loading. Degeneration of IVD is generally characterized by changes in disc
morphology, composition of extracellular matrix (ECM), loss of proteoglycan
and water content, and an up-regulation of metalloproteinases in IVD
[2,8-10]. Nonetheless, there is a lack of consensus on the cause of
degeneration. In particular, whether the degeneration is a result from a loss
of mechanical integrity in the disc or the mechanical loading itself being a
precipitating factor of the degeneration is still controversial [6,7].
Studies have also suggested that the degeneration is related to a change of
disc cells response to mechanical stimuli [11], but the molecular events
happened during the response have not been clearly elaborated. IVD consists
of three components: an outer fibrous ring (annulus fibrosus, AF), an inner
gelatinous filling (nucleus pulposus, NP), and cartilaginous endplates (EP)
which sandwich the former two structures. During organogenesis, NP is
developed from the transformation of notochord and AF is differentiated from
the condensation of sclerotome, implying that IVD is derived from mesodermal
origin [3,4]. IVD is populated by three major cell types: chondrocytes in EP,
notochordal/chondrocyte-like cells in NP and fibroblast-like cells in AF. NP
and AF contain abundant ECM, particularly collagens and proteoglycans, which
are present in different proportions in the two structures [6]. Cells in IVD
have been defined base on their morphology, intercellular organization, and
gene expression. NP is composed of a heterogeneous cell population of
interconnected cells with prominent vacuoles, which are thought to be
originated from the notochord, and small chondrocyte-like cells from yet
unknown origin [12]. The notochordal cells appear to be replaced with
chondrocyte-like cells during IVD maturation. The replacement of cells may be
possibly due to apoptosis of notochordal cells together with an invasion of
chondrocytes from AF or EP, or due to differentiation of notochordal cells
into chondrocytic phenotype. Study has demonstrated that degeneration is not
observed in IVD where notochordal cells persist to adult age, suggesting
notochordal cells play vital role in maintaining IVD integrity [21]. Among
various species studied, mature sheeps, dogs, and rats are suggested to
retain NP cell populations mimicking those in adult humans [12]. In situ
expression of variety of genes has been studies in NP. They express
chondrocyte markers such as SOX9, collagen II and IX, agreccan, decorin,
TGFbeta, and Ptc [13-18]. Gene knockout in mice has demonstrated that Sox5
and Sox6 regulate NP formation while Col |
|
List of Research Outputs |
|
Ho G., Leung Y.L., Chan D. and Cheung K.M.C., Effect of severity of intervertebral disc injury on mesenchymal stem cell-based regeneration, Connective Tissue Research. 2008, 49: 15-21. |
|
Leung Y.L., Hung S.C., Li L.C., Wu E.X., Luk K.D.K., Chan D. and Cheung K.M.C., Age-related degeneration of lumbar intervertebral disc in rabbit reveal by deuterium oxide-assisted MRI, Best Poster Award, World Forum for Spine Research - the intervertebral disc, first Japanese meeting, Kyoto, Japan, January 23-26, 2008 . 2008. |
|
Leung Y.L., Hung S.C., Li L.C., Wu E.X. and Luk K.D.K., Age-related degeneration of lumbar intervertebral discs in rabbits revealed by Deuterium Oxide-assisted MRI, Best General Poster Award, World Forum for Spine Research - the intervertebral disc, first Japanese meeting, Kyoto, Japan, January 23-26, 2008. 2008. |
|
Leung Y.L., Hung S.C., Chan Li L.C., Wu E.X., Luk K.D.K., Chan D. and Cheung K.M.C., Age-related degeneration of lumbar intervertebral discs in rabbits revealed by deuterium oxide-assisted MRI, World Forum for Spine Research - the Intervertebral Disc. 2008. |
|
Leung Y.L., Hung S.C., Chan Li L.C., Wu E.X., Luk K.D.K., Chan D. and Cheung K.M.C., Aged-related degeneration of lumbar intervertebral discs in rabbits revealed by deuterium oxide-assisted MRI, World Forum for Spine Research - The Interveretegral Disc, First Japanese Meeting, Kyoto, Japan, January 23-26, 2008. |
|
Leung Y.L., Best Poster Award, World Forum for Spine Research, AOSpine International. 2008. |
|
Leung
Y.L., Biological Response To Foreign
Materials, |
|
Leung Y.L., Wu E.X., Luk K.D.K., Chan D. and Cheung K.M.C., Cell quantity and degenerative stage dependent effect of allogeneic mesenchymal stem cells on regeneration of intervertebral disc, 14th International Meeting on Advanced Spine Techniques. 2007. |
|
Luk K.D.K., Leung Y.L., Hung S.C., Tsui Y.K., Lee M.K., Chan Li L.C., Lo G.G., Masuda K., Wu E.X. and Chan D., Allogeneic mesenchymal stem cell transplantation into the intervertebral disc; effect of severity of degeneration and cell number on regeneration, 15th Triennial Congress of Asia Pacific Orthopaedic Association, Seoul, Korea, September 9-13, 2007. |
|
Tsui
Y.K., Leung Y.L., Kao R.Y.T., Chan D., Masuda K. and Cheung K.M.C., High throughput screening
of chemical compounds for the treatment of osteoarthritis, Best Poster
Award, 12th Ressearch Postgraduate Symposium, The |
|
Zhou X.Z., Leung Y.L., Dong Q.R., Cheung K.M.C., Chan D. and Lu W.W., Mesenchymal stem cell-based repair of articular cartilage with polyglycolic acid-hydroxyapatite biphasic scaffold, Int J Artif Organs. 2008, 6: 480-9. |
|
Researcher
: Li YH |
|
List of Research Outputs |
|
Chen C.K., Li Y.H., Chow W. and Luk K.D.K., The modified Sofield-Millar operation in osteogenesis imperfecta - a review of ten years experience, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Researcher
: Li Z |
|
List of Research Outputs |
|
Abbah S.A., Lu W.W., Chan D., Cheung K.M.C., Zhao F., Li Z., Leong J.C.Y. and Luk K.D.K., Osteogenic behavior of alginate encapsulated bone marrow stromal cells: an in vitro study, J Mater Sci Mater Med. 2008, 19(5): 2113-9. |
|
Lam R.W.M., Wong C.T., Li Z., Luk K.D.K., Chan W.K., Yang C., Chiu P.K.Y., Xu B. and Lu W.W., Solvothermal synthesis of strontium phosphate chloride nanowire, Journal of Cystal Growth. 2007, 306: 129-134. |
|
Lam W.M.R., Wong C.T., Li Z., Luk K.D.K., Chan W.K., Yang C., Chiu P.K.Y., Xu B. and Lu W.W., Solvothermal synthesis of strontium phosphate chloride nanowire., Journal of Crystal Growth. 2007, 306 (1): 129-134. |
|
Leong J.C.Y., Li Z. and Lu W.W., Development and clinical trial of a novel bioactive bone cement, Frontiers of Medicine in China. 2008, 2(2): 117-26. |
|
Li Z., Yang C., Lu W.W., Xu B., Lam R.W.M., Ni G., Abbah S.A., Yang F., Cheung K.M.C. and Luk K.D.K., Characteristics and mechanical properties of acrylolpamidronate-treated strontium containing bioactive bone cement, J Biomed Mater Res B Appl Biomater. 2007, 83(2): 464-71. |
|
Li Z., Lu W.W., Lam R.W.M., Chiu P.K.Y., Cheung K.M.C. and Luk K.D.K., Micro-architectural and Nano-mechanical Properties of Trabecular Bone with Strontium Treatment in Osteoporotic Goats, 9th Regional Osteoporosis Conference, Hong Kong. 2008. |
|
Li Z., Lu W.W., Chiu P.K.Y., Lam R.W.M., Tang B., Ngan A.H.W., Wong C.T., Fang D., Cheung K.M.C. and Luk K.D.K., Micro-architectural and nano-mechanical properties of trabecular bone with strontium treatment in large animal model of osteoporosis, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2007, 11: S80. |
|
Li Z., Lu W.W., Chiu P.K.Y., Lam R.W.M., Tang B., Ngan A.H.W., Wong C.T., Fang D., Cheung K.M.C. and Luk K.D.K., Micro-architectural and nano-mechanical properties of trabecular bone with strontium treatment in large animal model of osteoporosis, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Li Z., Lu W.W., Chiu P.K.Y., Lam R.W.M., Cheung K.M.C., Tang B., Ngan A.H.W. and Luk K.D.K., Micro-architecture and Nano-mechanics of Lumbar Vertebra with Strontium Treatment in Large Animal Model of Osteoporosis, 54th Annual Meeting of the Orthopaedic Research Society, San Francisco, USA. 2008, P276. |
|
Lu W.W., Li Z., Chiu P.K.Y., Lam R.W.M., Yang C., Xu B., Wong C.T., Fang D., Cheung K.M.C. and Luk K.D.K., Bone composition and mineral crystal structure after strontium treatment for osteoporosis in goat model, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2007, 11: S79. |
|
Lu W.W., Li Z., Chiu P.K.Y., Lam R.W.M., Yang C., Xu B., Wong C.T., Fang D., Cheung K.M.C. and Luk K.D.K., Bone composition and mineral crystal structure after strontium treatment for osteoporosis in goat model, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Lu W.W., Li Z., Chiu P.K.Y., Lam R.W.M., Cheung K.M.C., Fang D., Leong J.C.Y. and Luk K.D.K., Mineral Crystal Composition and Structure of New Bone after Strontium Treatment for Osteoporosis in Goat Model, 54th Annual Meeting of the Orthopaedic Research Society, San Francisco, USA. 2008, P966. |
|
Lu W.W., Peng S.L., Zhou G., Luk K.D.K., Li Z., Wong C.T., Lam R.W.M. and Cheung K.M.C., Strontium promotes osteogenic differentiation and inhibits the osteoclastogenic potentials in murine mesenchymal stem cells, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Ni G., Lu W.W., Chiu P.K.Y., Wang Y., Li Z., Zhang Y.G., Xu B., Deng L.F. and Luk K.D.K., Mechanical properties of femoral cortical bone following cemented hip replacement, Journal of Orthopaedic Research. 2007, 1408-1414. |
|
Ni G.X., Lu W.W., Tang B., Ngan A.H.W., Chiu K.Y., Cheung K.M.C., Li Z. and Luk K.D.K., Effect Of Weight-bearing On
Bone-bonding Behavior Of Strontium-containing Hydroxyapatite Bone Cement, Journal
Of Biomedical Materials Research Part A. 111 RIVER ST, HOBOKEN, NJ 07030
USA, WILEY-LISS, DIV JOHN WILEY & SONS INC, 2007, |
|
Pan H., Li Z., Lam R.W.M., Wong C.T. and Lu W.W., Solubility study of 10% Sr-Hap and the effect of strontium by solid titration, 1st asian biomaterials congress, Tsukuba, Japan. 2007. |
|
Zheng Z.M., Luk K.D.K., Kuang G.M., Li Z., Lin J., Lam R.W.M., Cheung K.M.C. and Lu W.W., Vertebral augmentation with a novel vessel-x bone void filling container system and ioactive bone cement, Spine. 2007, 32(19): 2076-2082. |
|
Researcher
: Li Z |
|
List of Research Outputs |
|
Abbah S.A., Lu W.W., Chan D., Cheung K.M.C., Zhao F., Li Z., Leong J.C.Y. and Luk K.D.K., Osteogenic behavior of alginate encapsulated bone marrow stromal cells: an in vitro study, J Mater Sci Mater Med. 2008, 19(5): 2113-9. |
|
Lam R.W.M., Wong C.T., Li Z., Luk K.D.K., Chan W.K., Yang C., Chiu P.K.Y., Xu B. and Lu W.W., Solvothermal synthesis of strontium phosphate chloride nanowire, Journal of Cystal Growth. 2007, 306: 129-134. |
|
Lam W.M.R., Wong C.T., Li Z., Luk K.D.K., Chan W.K., Yang C., Chiu P.K.Y., Xu B. and Lu W.W., Solvothermal synthesis of strontium phosphate chloride nanowire., Journal of Crystal Growth. 2007, 306 (1): 129-134. |
|
Leong J.C.Y., Li Z. and Lu W.W., Development and clinical trial of a novel bioactive bone cement, Frontiers of Medicine in China. 2008, 2(2): 117-26. |
|
Li Z., Yang C., Lu W.W., Xu B., Lam R.W.M., Ni G., Abbah S.A., Yang F., Cheung K.M.C. and Luk K.D.K., Characteristics and mechanical properties of acrylolpamidronate-treated strontium containing bioactive bone cement, J Biomed Mater Res B Appl Biomater. 2007, 83(2): 464-71. |
|
Li Z., Lu W.W., Lam R.W.M., Chiu P.K.Y., Cheung K.M.C. and Luk K.D.K., Micro-architectural and Nano-mechanical Properties of Trabecular Bone with Strontium Treatment in Osteoporotic Goats, 9th Regional Osteoporosis Conference, Hong Kong. 2008. |
|
Li Z., Lu W.W., Chiu P.K.Y., Lam R.W.M., Tang B., Ngan A.H.W., Wong C.T., Fang D., Cheung K.M.C. and Luk K.D.K., Micro-architectural and nano-mechanical properties of trabecular bone with strontium treatment in large animal model of osteoporosis, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2007, 11: S80. |
|
Li Z., Lu W.W., Chiu P.K.Y., Lam R.W.M., Tang B., Ngan A.H.W., Wong C.T., Fang D., Cheung K.M.C. and Luk K.D.K., Micro-architectural and nano-mechanical properties of trabecular bone with strontium treatment in large animal model of osteoporosis, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Li Z., Lu W.W., Chiu P.K.Y., Lam R.W.M., Cheung K.M.C., Tang B., Ngan A.H.W. and Luk K.D.K., Micro-architecture and Nano-mechanics of Lumbar Vertebra with Strontium Treatment in Large Animal Model of Osteoporosis, 54th Annual Meeting of the Orthopaedic Research Society, San Francisco, USA. 2008, P276. |
|
Lu W.W., Li Z., Chiu P.K.Y., Lam R.W.M., Yang C., Xu B., Wong C.T., Fang D., Cheung K.M.C. and Luk K.D.K., Bone composition and mineral crystal structure after strontium treatment for osteoporosis in goat model, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2007, 11: S79. |
|
Lu W.W., Li Z., Chiu P.K.Y., Lam R.W.M., Yang C., Xu B., Wong C.T., Fang D., Cheung K.M.C. and Luk K.D.K., Bone composition and mineral crystal structure after strontium treatment for osteoporosis in goat model, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Lu W.W., Li Z., Chiu P.K.Y., Lam R.W.M., Cheung K.M.C., Fang D., Leong J.C.Y. and Luk K.D.K., Mineral Crystal Composition and Structure of New Bone after Strontium Treatment for Osteoporosis in Goat Model, 54th Annual Meeting of the Orthopaedic Research Society, San Francisco, USA. 2008, P966. |
|
Lu W.W., Peng S.L., Zhou G., Luk K.D.K., Li Z., Wong C.T., Lam R.W.M. and Cheung K.M.C., Strontium promotes osteogenic differentiation and inhibits the osteoclastogenic potentials in murine mesenchymal stem cells, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Ni G., Lu W.W., Chiu P.K.Y., Wang Y., Li Z., Zhang Y.G., Xu B., Deng L.F. and Luk K.D.K., Mechanical properties of femoral cortical bone following cemented hip replacement, Journal of Orthopaedic Research. 2007, 1408-1414. |
|
Ni G.X., Lu W.W., Tang B., Ngan A.H.W., Chiu K.Y., Cheung K.M.C., Li Z. and Luk K.D.K., Effect Of Weight-bearing On
Bone-bonding Behavior Of Strontium-containing Hydroxyapatite Bone Cement, Journal
Of Biomedical Materials Research Part A. 111 RIVER ST, HOBOKEN, NJ 07030
USA, WILEY-LISS, DIV JOHN WILEY & SONS INC, 2007, |
|
Pan H., Li Z., Lam R.W.M., Wong C.T. and Lu W.W., Solubility study of 10% Sr-Hap and the effect of strontium by solid titration, 1st asian biomaterials congress, Tsukuba, Japan. 2007. |
|
Zheng Z.M., Luk K.D.K., Kuang G.M., Li Z., Lin J., Lam R.W.M., Cheung K.M.C. and Lu W.W., Vertebral augmentation with a novel vessel-x bone void filling container system and ioactive bone cement, Spine. 2007, 32(19): 2076-2082. |
|
Researcher
: Liu H |
|
List of Research Outputs |
|
Liu H., Hu Y., Chang C. and Luk K.D.K., Fast extraction of somatosensory evoked potential based on second order blind identification, IEEE EMBS Annual Conference (EMBS2007). 2007. |
|
Shen
C., Liu H., Xie X., Luk K.D.K. and Hu Y., Selection of floating-point or
fixed-point For Adaptive Noise Canceller In Somatosensory Evoked Potential
Measurement., Annual International Conference of the IEEE Engineering in
Medicine and Biology Society. |
|
Researcher
: Liu H |
|
List of Research Outputs |
|
Liu H., Hu Y., Chang C. and Luk K.D.K., Fast extraction of somatosensory evoked potential based on second order blind identification, IEEE EMBS Annual Conference (EMBS2007). 2007. |
|
Shen
C., Liu H., Xie X., Luk K.D.K. and Hu Y., Selection of floating-point or
fixed-point For Adaptive Noise Canceller In Somatosensory Evoked Potential
Measurement., Annual International Conference of the IEEE Engineering in
Medicine and Biology Society. |
|
Researcher
: Liu K |
|
List of Research Outputs |
|
Liu
K., Chiu
P.K.Y., |
|
Yau
W.P., Leung A., Liu K.,
Yan C.H. and Chiu P.K.Y., Can minimal
incision approach be combined with computer assisted navigation total knee
replacement? – A cadaveric study, 15th Triennial Congress of |
|
Yau
W.P., Liu K., Yan C.H. and
Chiu P.K.Y., Errors in Identification
of the Distal Femur Transepicondylar and Anterior Posterior Axes in Minimal
Incision TKR and Conventional Incision TKR Using Image Free Computer
Navigation System, 8th Annual Meeting of Computer Assisted Orthopaedic
Surgery -International Association. 2008, June 5-7, |
|
Researcher
: Lu W |
|
List of Research Outputs |
|
Ip W.Y., Chow S.P., Lam K.W., Gibson I., Ngan A.H.W., Lu W. and Chiu P.K.Y., A Novel Artificial Prosthetic Replacement For The Proximal Interphalangeal Joint Of The Hand - From Concept To Prototype, Australian Orthopaedic Association Continuing Orthopaedic Education Meeting . 2008. |
|
Researcher
: Lu WW |
|
Project Title: |
Use of a new bioactive bone cement in the treatment of osteoporotic spinal fracture |
|
Investigator(s): |
Lu WW, Fong DYT, Cheung KMC, Ni G, Luk KDK |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
S.K. Yee Medical Foundation - General Award |
|
Start Date: |
10/2004 |
|
Abstract: |
|
To help the poor and sick who suffer from
osteoporotic spinal fractures; to apply for the market permit both in Hong
Kong and |
|
Project Title: |
Novel Strontium Hydroxyapatite Nanowhisker (Sr-HA-Nano) reinforced bioactive cement for bone fracture treatment |
|
Investigator(s): |
Lu WW, Chan WK, Xu B, Ngan AHW, Luk KDK |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Innovation and Technology Support Programme |
|
Start Date: |
09/2006 |
|
Abstract: |
|
(1) To develop a novel strontium-hydroxyapatite nanowhisker (Sr-HA-Nano) reinforced bioactive bone cement. (2) To provide a complete mechanical and biocompatible profile of novel Sr-HA nanowhisker cement follow ISO 5883 and ISO 10993 standards. The key issue of this study is to improve bending and fatigue strength of the current Sr-HA bioactive bone cement. Based on literature review, the weak filler fracture toughness, the microvoid formation during mixing, and the filler aggregations are the major cause of lower mechanical strength. One solution to solve these problems is to reinforce the cement with the stronitum hydroxyapatite nanowhisker and by surface treatment using acrylolpamidonate. To further increase the mechanical strength of the novel bioactive boen cement, we will apply surface treatment to the inorganic fillers using acrylolpamidonate which will increases filler surface hydrophobicity assisting dispersion within non-polar resin phase. |
|
Project Title: |
Pullout strength of screws from bioactive bone cement vs Polymethylmethacrylate bone cement |
|
Investigator(s): |
Lu WW, Luk KDK, Cheung KMC |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
12/2006 |
|
Abstract: |
|
The purpose of this study is to examine
and compare the pullout strengths of pedicle screws from bioactive
strontium-containing hydroxyapatite bone cement (Sr-HA) and
polymethylmethacrylate bone cement (PMMA) in different insertion timings. The
pedicle screw is a component of spinal implants commonly used in spinal fusion
for various diseases such as scoliosis, infection and tumour. In patients
suffering from osteoporosis or a tumour, the bone quality of their vertebrae
would be weakened and render the fixation of a pedicle screw unsecured. A
surgeon might utilise bone cement, classically PMMA, to augment the screw
purchase. PMMA is not a glue, rather, is an inert void filler. It cannot
encourage bone ingrowth and might even fail with time due to mechanical
fatigue. On the contrary, the bioactive Strontium-Hydroxapatite bone cement,
which was developed, patented and commercialised by the Department of
Orthopaedics and Traumatology at Hong Kong University, might surpass the
traditional PMMA by the virtue of its unique ability to promote bone
ingrowth. Even for the classical PMMA bone cement, there have been only a few
articles concering the pullout strength of screws. Flahiff et al discovered
that the pullout strength was highest for screws inserted into doughy cement
and lowest for screws inserted into hard cement. Apart from the strength, the
modes of failure were also different. It was postulated that the timing of
screw insertion cast an effect on interdigitation and hence the strength in
screw-cement and bone-cement interfaces. However, as the experiment carried a
lot of variables, conclusion of the best timing could hardly be arrived at.
To simplify the model, Motzkin et al utilised cement blocks for mechanical
test. They found a significantly stronger pullout strength for screws placed
in fluid and solid polymethylmethacrylate (PMMA). Critics arose as they only
tested cement blocks with a thickness of |
|
Project Title: |
The micro-structure and micro-mechanics of human intervertebral disc |
|
Investigator(s): |
Lu WW, Ngan AHW, Cheung KMC, Luk KDK |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Competitive Earmarked Research Grants (CERG) |
|
Start Date: |
12/2006 |
|
Abstract: |
|
(1) Purpose: This study aims to apply
state-of-the-art techniques to study the micro and nano mechanical properties
of both normal human intervertebral discs and discs at different grades of
degeneration, producing a database available for future reference. (2)
Objectives: (a) Testing the mechanics of a bundle of collagen fibrils from
Annulus Fibrosus of human intervertebral discs; and (b) Mechanically testing
the individual collagen fibrils at nano-level by stretching the fibrils in
force spectroscopy mode (contact mode) of the Atomic Force Microscope (AFM).
(3) Key issues: Low back pain (LBP) is a common and significant problem
worldwide. Compensation for occupation related injuries and LBP in |
|
Project Title: |
Optimization and commercialization of strontium containing bioactive bone cement for various orthopaedic applications |
|
Investigator(s): |
Lu WW, Chan WK, Xu B, Chiu PKY, Luk KDK, Ngan AHW |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Guangdong-Hong Kong Technology Cooperation Funding Scheme |
|
Start Date: |
04/2007 |
|
Abstract: |
|
(1) Optimize and commercialize three new brands of Sr-HA bone cement to fulfill the application in three major areas: (i) Osteoporotic spinal fracture (Sr-HA Spine), (ii) Total hip replacement implant augmentation (Sr-HA Hip) and (iii) Bone tumor, or bone cavity filler (Sr-HA Filler). (2) Provide a complete mechancial and biocompatibility profile of the modified Sr-HA cement formulation as per the ISO 5883 and ISO 10993 standards. (3) Carry out 30-35 cases of clinical trials on bioactive bone cement as a total hip replacement fixation agent. (4) Filing the standards for application to local or international medical device licensing organizations for marketing. The key issue of this study is to optimize present Sr-HA bioactive bone cement by modifying its composition to fulfill a wied variety of orthopaedic application requirements while preserving its desired properties of bioactivity and osteointegration. Ultimately, we aim at replacing the current non-bioactive PMMA bone cement with bioactive bone cements suitable for the particular needs which can significantly reduce clincial complications and improve the quality of life among the patients. |
|
List of Research Outputs |
|
Abbah S.A., Lu W.W., Chan D., Cheung K.M.C., Zhao F., Li Z., Leong J.C.Y. and Luk K.D.K., Osteogenic behavior of alginate encapsulated bone marrow stromal cells: an in vitro study, J Mater Sci Mater Med. 2008, 19(5): 2113-9. |
|
Aladin Kaderbatcha D.M., Lu W.W., Cheung K.M.C., Ngan A.H.W., Chan D. and Luk K.D.K., Association of Trp2 allele with changes in morphology and nano mechanics of the human intervertebral disc collagens, Best Basic Science Paper Award for Associate Member, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. 2007. |
|
Aladin
Kaderbatcha D.M., Lu W.W.,
Cheung K.M.C., Ngan A.H.K., Chan D. and Luk K.D.K., Correlation between the
Compressive Macro-mechanical Properties of the Human Nucleus Pulposus and the
Nano Structure of its Individual Collagen Fibrils, World Forum for Spine
Research - The Intervertebral Disc. |
|
Aladin
Kaderbatcha D.M., Cheung K.M.C., Chan D., Yee A.F.Y., Jim J.J.T., Luk K.D.K. and Lu W.W., Expression of the Trp2
allele of COL |
|
Chan
C.W., Gantenbein B., Leong V.Y.L.,
Chan D., Lu W.W., Luk K.D.K., Cheung K.M.C. and Ito K., Cell
Repopulation of the Frozen Intervertebral Disc by Bone Marrow-derived Stromal
Cells., World Forum for Spine Research - The Intervertebral Disc. |
|
Chan
Y.L., Wu S.L., Liu X.M., |
|
Gibson I., Chow S.P., Lam K.W., Lu W.W., NGAN H.W., Ip W.Y. and Chiu P.K.Y., The Development Of An
Artifical Finger Joint, In: Paulo Bartolo, Bopaya Bidanda, Bio-materials
And Prototyping Applications In Medicine. |
|
Hu Y., Leung H.B., Lu W.W. and Luk K.D.K., Histological and electrophysiological changes of the Paraspinal Muscle after Spinal Fusion: an Experimental Study., Spine. 2008, 33: 1418-22. |
|
Lam R.W.M., Wong C.T., Li Z., Luk K.D.K., Chan W.K., Yang C., Chiu P.K.Y., Xu B. and Lu W.W., Solvothermal synthesis of strontium phosphate chloride nanowire, Journal of Cystal Growth. 2007, 306: 129-134. |
|
Lam W.M.R., Wong C.T., Li Z., Luk K.D.K., Chan W.K., Yang C., Chiu P.K.Y., Xu B. and Lu W.W., Solvothermal synthesis of strontium phosphate chloride nanowire., Journal of Crystal Growth. 2007, 306 (1): 129-134. |
|
Leong J.C.Y., Li Z. and Lu W.W., Development and clinical trial of a novel bioactive bone cement, Frontiers of Medicine in China. 2008, 2(2): 117-26. |
|
Li Z., Yang C., Lu W.W., Xu B., Lam R.W.M., Ni G., Abbah S.A., Yang F., Cheung K.M.C. and Luk K.D.K., Characteristics and mechanical properties of acrylolpamidronate-treated strontium containing bioactive bone cement, J Biomed Mater Res B Appl Biomater. 2007, 83(2): 464-71. |
|
Li Z., Lu W.W., Lam R.W.M., Chiu P.K.Y., Cheung K.M.C. and Luk K.D.K., Micro-architectural and Nano-mechanical Properties of Trabecular Bone with Strontium Treatment in Osteoporotic Goats, 9th Regional Osteoporosis Conference, Hong Kong. 2008. |
|
Li Z., Lu W.W., Chiu P.K.Y., Lam R.W.M., Tang B., Ngan A.H.W., Wong C.T., Fang D., Cheung K.M.C. and Luk K.D.K., Micro-architectural and nano-mechanical properties of trabecular bone with strontium treatment in large animal model of osteoporosis, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2007, 11: S80. |
|
Li Z., Lu W.W., Chiu P.K.Y., Lam R.W.M., Tang B., Ngan A.H.W., Wong C.T., Fang D., Cheung K.M.C. and Luk K.D.K., Micro-architectural and nano-mechanical properties of trabecular bone with strontium treatment in large animal model of osteoporosis, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Li Z., Lu W.W., Chiu P.K.Y., Lam R.W.M., Cheung K.M.C., Tang B., Ngan A.H.W. and Luk K.D.K., Micro-architecture and Nano-mechanics of Lumbar Vertebra with Strontium Treatment in Large Animal Model of Osteoporosis, 54th Annual Meeting of the Orthopaedic Research Society, San Francisco, USA. 2008, P276. |
|
Liu X.M., Wu S.L., |
|
Liu X.M., Wu S.L., |
|
Lu W.W., (Reviewer), Biomaterials . 2007. |
|
Lu W.W., Li Z., Chiu P.K.Y., Lam R.W.M., Yang C., Xu B., Wong C.T., Fang D., Cheung K.M.C. and Luk K.D.K., Bone composition and mineral crystal structure after strontium treatment for osteoporosis in goat model, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2007, 11: S79. |
|
Lu W.W., Li Z., Chiu P.K.Y., Lam R.W.M., Yang C., Xu B., Wong C.T., Fang D., Cheung K.M.C. and Luk K.D.K., Bone composition and mineral crystal structure after strontium treatment for osteoporosis in goat model, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Lu W.W., Li Z., Chiu P.K.Y., Lam R.W.M., Cheung K.M.C., Fang D., Leong J.C.Y. and Luk K.D.K., Mineral Crystal Composition and Structure of New Bone after Strontium Treatment for Osteoporosis in Goat Model, 54th Annual Meeting of the Orthopaedic Research Society, San Francisco, USA. 2008, P966. |
|
Lu W.W., Peng S.L., Zhou G., Luk K.D.K., Li Z., Wong C.T., Lam R.W.M. and Cheung K.M.C., Strontium promotes osteogenic differentiation and inhibits the osteoclastogenic potentials in murine mesenchymal stem cells, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Ni G., Lu W.W., Chiu P.K.Y., Wang Y., Li Z., Zhang Y.G., Xu B., Deng L.F. and Luk K.D.K., Mechanical properties of femoral cortical bone following cemented hip replacement, Journal of Orthopaedic Research. 2007, 1408-1414. |
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Ni G.X., Lu W.W., Tang B., Ngan A.H.W., Chiu K.Y., Cheung K.M.C., Li Z. and Luk K.D.K., Effect Of Weight-bearing On
Bone-bonding Behavior Of Strontium-containing Hydroxyapatite Bone Cement, Journal
Of Biomedical Materials Research Part A. 111 RIVER ST, HOBOKEN, NJ 07030
USA, WILEY-LISS, DIV JOHN WILEY & SONS INC, 2007, |
|
Pan
H., Li Z., Lam R.W.M., Wong C.T. and Lu W.W., Solubility study of 10%
Sr-Hap and the effect of strontium by solid titration, 1st asian
biomaterials congress, |
|
Poon R.W.Y., |
|
Wong K.L., Tang W.M., Lu W.W., Cheung W.L. and Chiu P.K.Y., Mechanical properties of polyetheretherketone-strontium hydroxyapatite composites , 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2007, 11: S111. |
|
Wu S.L., Liu X.M., Chan Y.L., Chung C.Y., |
|
Yang
F., Chan D., Leung Y.L., Lu W.W., Luk K.D.K. and Cheung K.M.C., Dynamic Changes of Type
II Collagen in the Degenerated Murine Discs., World Forum for Spine
Research - The Intervertebral Disc. |
|
Yeung
K.W.K., Chan Y.L., Lama K.O., Wu
S.L., Liu X.M., Chung C.Y., |
|
Yeung
K.W.K., Chan Y.L., Lam K.O., Liu X.M., Wu S.L., Liu X.Y.,
Chung C.Y., Lu W.W., Chan D., Luk K.D.K., |
|
Yeung
K.W.K., Poon R.W.Y., |
|
Zhao X., Liu W., Chen D., Lin X. and Lu W.W., Effect of Block Order of ABA- and BAB-Type NIPAAm/HEMA Triblock Copolymers on Thermoresponsive Behavior of Solutions, Macromolecular Chemistry and Physics. 2007, 208: 1773-1781. |
|
Zheng Z.M., Luk K.D.K., Kuang G.M., Li Z., Lin J., Lam R.W.M., Cheung K.M.C. and Lu W.W., Vertebral augmentation with a novel vessel-x bone void filling container system and ioactive bone cement, Spine. 2007, 32(19): 2076-2082. |
|
Zhou X.Z., Leung Y.L., Dong Q.R., Cheung K.M.C., Chan D. and Lu W.W., Mesenchymal stem cell-based repair of articular cartilage with polyglycolic acid-hydroxyapatite biphasic scaffold, Int J Artif Organs. 2008, 6: 480-9. |
|
Researcher
: Luk KDK |
|
Project Title: |
A minimal invasive approach to anterior release in scoliosis by chemonucleolysis: an experimental study with the rabbit scoliosis model |
|
Investigator(s): |
Luk KDK |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Outstanding RGC Projects |
|
Start Date: |
09/1998 |
|
Abstract: |
|
To investigate whether the effect of chymopapain on generating spinal lateral instability can be used to treat scoliosis deformity; to develop a thoracoscopic-assisted or CT-guided chemonucleolysis technique to replace the conventional anterior spinal release method. |
|
Project Title: |
Provision of individualized biomechanical and electrophysiological service for occupational low back disorder patients |
|
Investigator(s): |
Luk KDK, Lu WW, Hu Y |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
S.K. Yee Medical Foundation - General Award |
|
Start Date: |
12/2003 |
|
Abstract: |
|
To assess the low back muscular function and biomechanical problems of low back disorder patients to identify, evaluate and quantify potential of factors of OLBD; to study the drawbacks and benefits of conventional treatments; to introduce an individualized biomechanical and electrophysiological assessment service to identify specific OLBD problems in individual patients, and provide guidelines both for an optimal rehabilitation treatment and for a future workplace regimen to prevent recurrence. |
|
Project Title: |
Investigation on in-vivo Mechanical Properties of Degenerated Intervertebral Disc Using Magnetic Resonance Elastography |
|
Investigator(s): |
Luk KDK |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
03/2005 |
|
Abstract: |
|
Intervertebral disc degeneration is frequently cited as a cause of low back pain as it would lead to changes in mechanical properties of the disc, causing instability of the spine. In most of the cases, “black disc” and “high intensity zone” in MRI are diagnostic signs of disc degeneration but there is no definite evidence that this is the gold standard for diagnosis of low back pain. With the development of the MRI techniques, Magnetic Resonance Elastography (MRE), it allows in-vivo measurement of the mechanical properties of different tissues. MRE is a phase-contrast-based technique that can directly visualize and quantitatively measure local values of shear modulus, elasticity and stiffness by propagating acoustic strain waves in tissue subjected to harmonic mechanical excitation[1, 2]. Since the discovery of MRE, studies have been performed in animal tissue[3, 4], human brain[5] and human skeletal muscle[6] to find the mechanical properties of different tissues. MRE has also been shown to be an effective diagnostic tool for breast cancer[7, 8]. However, this technique has not been developed in the intervertebral disc and its application on diagnosis of disc diseases has not yet been explored either. In the current study, we will apply MRE to disc. Objective This study will apply MRE to detect the mechanical property of spinal disc in normal subjects and patients with degenerative disc disease. Mechanical property change due to pathological condition will be characterized. References [1] R. Muthupillai, P. J. Rossman, D. J. Lomas, J. F. Greenleaf, S. J. Riederer & R. L. Ehman, Magnetic resonance imaging of transverse acoustic strain waves, Magn Reson Med 36(2), 1996, 266-274. [2] R. Muthupillai, D. J. Lomas, P. J. Rossman, J. F. Greenleaf, A. Manduca & R. L. Ehman, Magnetic resonance elastography by direct visualization of propagating acoustic strain waves, Science 269(5232), 1995, 1854-1857. [3] S. A. Kruse, J. A. Smith, A. J. Lawrence, M. A. Dresner, A. Manduca, J. F. Greenleaf & R. L. Ehman, Tissue characterization using magnetic resonance elastography: preliminary results, Phys. Med. Biol. 45, 2000, 1579-1590. [4] J. Bishop, G. Poole, M. Leitch & D. B. Plewes, Magnetic resonance imaging of shear wave propagation in excised tissue, J Magn Reson Imaging 8(6), 1998, 1257-1265. [5] S. A. Kruse, M. A. Dresner, P. J. Rossman, J. P. Felmlee, C. R. Jack & R. L. Ehman, 'Palpation of the brain' using magnetic resonance Ultraelastography. 7thISMRM, 1999, 258. [6] M. A. Dresner, G. H. Rose, P. J. Rossman, J. A. Smith, R. Muthupillai & R. L. Ehman, Functional MR elastography of human skeletal muscle. 6thISMRM, 1998, 463. [7] A. J. Lawrence, P. J. Rossman, J. L. Mahowald, A. Manduca, L. C. Hartmann & R. L. Ehman, Assessment of breast cancer by magneticresonance elastography. 7thISMRM, 1999, 525. [8] R. Sinkus, J. Lorenzen, D. Schrader, M. Lorenzen, M. Dargatz & D. Holz, High-resolution tensor MR elastography for breast tumour detection, Phys Med Biol 45(6), 2000, 1649-1664. |
|
Project Title: |
Proposal to develop the strategic research area on biomedical engineering |
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Investigator(s): |
Luk KDK, Man RYK, Che CM, Cheung LK, Cheung PYS, Lu WW |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Seed Funding for Strategic Research Theme |
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Start Date: |
05/2005 |
|
Abstract: |
|
To improve quality of life through pioneering scientific discoveries and the education of future leaders in the medical and biotehnology fields. To establish an intra-institutional Biomedical Engineering research area with three sub-themes: Biomaterials and Tissue engineering; Electro-physioloyg/signal processing; Imaging/MRI. To foster interdisciplinary biomedical engineering by setting up a BME research core facility platform and to jointly secure external research grants. Establish joint appointments or ADjunct Professorship between Faculties of Dentistry, Engineering, Medicine, and Science. Recruitment RAP, PDF and RPG in these areas. Plan a unique integration between academia, clinical medicine and industry which enable biotechnology transfer. |
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Project Title: |
Spinal perfusion imaging in cervical myelopathy patients |
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Investigator(s): |
Luk KDK, Yang ES, Hu Y, Wu EX |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
03/2006 |
|
Abstract: |
|
The objective of this project is to apply
perfusion imaging (PI), a magnetic resonance dynamic imaging technique, to
investigate the haemoglobin status of the cervical spinal cord, which may
reveal the mechanism of surgical treatment on cervical spondylotic myelopathy
(CSM). CSM is the most common spinal cord disorder affecting the elderly, and
its incidence has increased significantly in recent years with the aging
trend in the population in |
|
List of Research Outputs |
|
Abbah S.A., Lu W.W., Chan D., Cheung K.M.C., Zhao F., Li Z., Leong J.C.Y. and Luk K.D.K., Osteogenic behavior of alginate encapsulated bone marrow stromal cells: an in vitro study, J Mater Sci Mater Med. 2008, 19(5): 2113-9. |
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Aladin Kaderbatcha D.M., Lu W.W., Cheung K.M.C., Ngan A.H.W., Chan D. and Luk K.D.K., Association of Trp2 allele with changes in morphology and nano mechanics of the human intervertebral disc collagens, Best Basic Science Paper Award for Associate Member, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. 2007. |
|
Aladin
Kaderbatcha D.M., Lu W.W., Cheung K.M.C., Ngan A.H.K., Chan D. and Luk K.D.K., Correlation between the
Compressive Macro-mechanical Properties of the Human Nucleus Pulposus and the
Nano Structure of its Individual Collagen Fibrils, World Forum for Spine
Research - The Intervertebral Disc. |
|
Aladin
Kaderbatcha D.M., Cheung K.M.C., Chan D., Yee A.F.Y., Jim J.J.T., Luk K.D.K. and Lu W.W., Expression of the Trp2 allele
of COL |
|
Chan C.C.Y., Chan D., Luk K.D.K. and Cheah K.S.E., Understanding the Function of Sedl gene and the Molecular Pathogenesis of spondyloepiphyseal Dysplasia Tarda., 7th Pan Pacific Connective Tissue Societies Symposium 2007 - Shangri-La Resort, Cairns, Australia. October 28 – November 1, 2007. |
|
Chan
C.W., Gantenbein B., Leong V.Y.L.,
Chan D., Lu W.W., Luk K.D.K., Cheung K.M.C. and Ito K., Cell
Repopulation of the Frozen Intervertebral Disc by Bone Marrow-derived Stromal
Cells., World Forum for Spine Research - The Intervertebral Disc. |
|
Chan
Y.L., Wu S.L., Liu X.M., |
|
Chen C.K., Li Y.H., Chow W. and Luk K.D.K., The modified Sofield-Millar operation in osteogenesis imperfecta - a review of ten years experience, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
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Cheung C.L., Sham P.C., Chan V.N.Y., Paterson A.D., Luk K.D.K. and Kung A.W.C., Identification of LTBP2 on chromosome 14q as a novel candidate gene for BMD variation and fracture risk association, Hong Kong Society of Endocrinology, Metabolism and Reproduction Annual Scientific Meeting, Hong Kong. 2007. |
|
Cheung
K.M.C., Karppinen J., Chan D., Fan B., Ho D.W.H., Kao P.Y.P., Song Y., Sham P.C., Cheah K.S.E., Leong J.C.Y. and Luk K.D.K., Age-related changes
versus degenerative disc disease. World Forum for Spine Research, World
Forum for Spine Research - The Intervertebral Disc. |
|
Cheung K.M.C., Song Y., Ho D.W.H., Poon S.C.S., Chiba K., Kawaguchi Y., Hirose Y., Alini M., Grad S., Yee A.F.Y., Leong J.C.Y., Luk K.D.K., Yip S.P., Karppinen J., Cheah K.S.E., Sham P.C., Ikegawa S. and Chan D., Association of the asporin D14 allele with lumbar disc degeneration, Spineweek 2008, Geneva, Switzerland, May 26-31, 2008. |
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Cheung K.M.C., Cheng Y.L., Chan C.W., Yeung K.W.K. and Luk K.D.K., Outcome assessment of braciing in adolescent idiopathic scoliosis by the use of the SRS-22 questionnaire, International Orthopaedics. 2007, 31(4): 507-511. |
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Cheung K.M.C., Cheng A.C.S., Cheung W.Y., Chooi Y.S., Wong Y.W. and Luk K.D.K., Right hip adduction deficit is prevalent in patients with adolescent idiopathic scoliosis, Journal of Orthopaedic Surgery. 2008, 16(1): 24-26. |
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Cheung K.M.C., Wu J.P., Cheng Q.H., Ma S.C., Gao J.C. and Luk K.D.K., Treatment of stiff thoracic scoliosis by thoracoscopic anterior release combined with posterior instrumentation and fusion: a retrospective study, The Journal of Orthopaedic Surgery and Research. 2007, 2(1): 16. |
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Cheung W.Y., Arvinte D., Wong Y.W., Luk K.D.K. and Cheung K.M.C., Neurological recovery after surgical decompression in patients with cervical spondylotic myelopathy - a prospective study, International Orthopaedics. 2008, 32(2): 273-278. |
|
Choi M.Y., Chan C., Chan D., Luk K.D.K., Cheah K.S.E. and Tanner J.A., Correlating Protein Structure with Disease - Understanding the Mechanism of SEDT, 12th Research Postgraduate Symposium, December 12 & 14, 2007 . 2007. |
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Dai Z., Cheung C.L., Sham P.C., Chan V.N.Y., Luk K.D.K., Paterson A. and Kung A.W.C., Positional cloning identified estrogen receptor beta, estrogen related receptor beta, BMP4, LTBP2 as the candidate genes for the quantitative trait locus in chromosome 14 for BMD variation, ASBMR 29th Annual Meeting, Honolulu, Hawaii, USA, September 16-19, 2007. – Oral presentation. 2007. |
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Ho D.W.H., Cheung K.M.C., Chan D., Karppinene J., Yip S.P., Ott J., Luk K.D.K., Leong J.C.Y., Cheah K.S.E., Sham P.C. and Song Y., Linkage Analysis on Familial Early-onset Degenerative Disc Disease, 12th Research Postgraduate Symposium, December 12 & 14, 2007 . 2007. |
|
Ho
D.W.H., Cheung K.M.C., Chan D., Karppinen J., Yip S.P., Ott J.,
Luk K.D.K., Leong J.C.Y., Cheah K.S.E., Sham P.C. and Song Y., Linkage analysis on familial
early-onset degenerative disc disease. World Forum for Spine Research., The
Intervertebral Disc. |
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Hu Y., Leung H.B., Lu W.W. and Luk K.D.K., Histological and electrophysiological changes of the Paraspinal Muscle after Spinal Fusion: an Experimental Study., Spine. 2008, 33: 1418-22. |
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Hu Y., Ding Y., Yuan D., Wong Y.W., Cheung K.M.C. and Luk K.D.K., Prognostic value of somatosensory-evoked potentials in the surgical management of cervical spondylotic myelopathy, Spine. 2008, 33: E305-10. |
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Hu Y.,
Mak J.N.F., Wong Y.W., Leong J.C.Y. and Luk K.D.K., Quality of life of
traumatic spinal cord injured patients in |
|
Hu Y.,
Jiang F. and Luk K.D.K.,
Time-frequency Feature of Intraoperative Somatosensory Evoked Potential
Signals., In: , Annual International Conference of the IEEE Engineering in
Medicine and Biology Society. |
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Kao P.Y.P., Chan D., Cheung K.M.C., Ho D.W.H., Karppinen J., Leong J.C.Y., Luk K.D.K., Yip S.P., Cheah K.S.E., Song Y. and Sham P.C., Genome-wide association study of degenerative disc disease (DDD)., Spine Week 2008, Geneva, May 26-31, 2008. . 2008. |
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Kao
P.Y.P., Chan D., Cheah K.S.E., Cheung K.M.C., Ho D.W.H., Karppinen J., Leong J.C.Y., Luk K.D.K., Yip S.P., Song Y. and Sham P.C., Genome-wide association study
of degenerative disc disease (DDD)., World Forum for Spine Research - The
Intervertebral Disc. |
|
Kao P.Y.P., Chan D., Cheung K.M.C., Ho D.W.H., Karppinen J., Leong J.C.Y., Luk K.D.K., Yip S.P., Cheah K.S.E., Song Y., Sham P.C. and Sham P.C., Genome-wide association study of degenerative disc disease, Spineweek 2008, Geneva, Switzerland, May 26-31, 2008. |
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Kung A.W.C., Lee K.K., Ho A.Y.Y., Tang G.W.K. and Luk K.D.K., Ten-Year Risk of Osteoporotic Fractures in Postmenopausal Chinese Women According to Clinical Risk Factors and BMD T Scores: A Prospective Study, Journal of Bone and Mineral Research. 2007, 22: 1080-7. |
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Lai M.H., Cheung C.L., Luk K.D.K. and Kung A.W.C., Estrogen receptor α CA dinucleotide repeat polymorphism is associated with rate of bone loss in perimenopausal women and bone mineral density and risk of osteoporotic fractures in postmenopausal women, Osteoporosis International. 2007, 19: 571-9. |
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Lam
K.O., Yeung K.W.K., Chan Y.L., Wu S.L., Liu X.M., Chung
C.Y., |
|
Lam R.W.M., Wong C.T., Li Z., Luk K.D.K., Chan W.K., Yang C., Chiu P.K.Y., Xu B. and Lu W.W., Solvothermal synthesis of strontium phosphate chloride nanowire, Journal of Cystal Growth. 2007, 306: 129-134. |
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Lam W.M.R., Wong C.T., Li Z., Luk K.D.K., Chan W.K., Yang C., Chiu P.K.Y., Xu B. and Lu W.W., Solvothermal synthesis of strontium phosphate chloride nanowire., Journal of Crystal Growth. 2007, 306 (1): 129-134. |
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Leung Y.L., Hung S.C., Li L.C., Wu E.X., Luk K.D.K., Chan D. and Cheung K.M.C., Age-related degeneration of lumbar intervertebral disc in rabbit reveal by deuterium oxide-assisted MRI, Best Poster Award, World Forum for Spine Research - the intervertebral disc, first Japanese meeting, Kyoto, Japan, January 23-26, 2008 . 2008. |
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Leung Y.L., Hung S.C., Li L.C., Wu E.X. and Luk K.D.K., Age-related degeneration of lumbar intervertebral discs in rabbits revealed by Deuterium Oxide-assisted MRI, Best General Poster Award, World Forum for Spine Research - the intervertebral disc, first Japanese meeting, Kyoto, Japan, January 23-26, 2008. 2008. |
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Leung Y.L., Hung S.C., Chan Li L.C., Wu E.X., Luk K.D.K., Chan D. and Cheung K.M.C., Age-related degeneration of lumbar intervertebral discs in rabbits revealed by deuterium oxide-assisted MRI, World Forum for Spine Research - the Intervertebral Disc. 2008. |
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Leung Y.L., Hung S.C., Chan Li L.C., Wu E.X., Luk K.D.K., Chan D. and Cheung K.M.C., Aged-related degeneration of lumbar intervertebral discs in rabbits revealed by deuterium oxide-assisted MRI, World Forum for Spine Research - The Interveretegral Disc, First Japanese Meeting, Kyoto, Japan, January 23-26, 2008. |
|
Leung Y.L., Wu E.X., Luk K.D.K., Chan D. and Cheung K.M.C., Cell quantity and degenerative stage dependent effect of allogeneic mesenchymal stem cells on regeneration of intervertebral disc, 14th International Meeting on Advanced Spine Techniques. 2007. |
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Li Z., Yang C., Lu W.W., Xu B., Lam R.W.M., Ni G., Abbah S.A., Yang F., Cheung K.M.C. and Luk K.D.K., Characteristics and mechanical properties of acrylolpamidronate-treated strontium containing bioactive bone cement, J Biomed Mater Res B Appl Biomater. 2007, 83(2): 464-71. |
|
Li Z., Lu W.W., Lam R.W.M., Chiu P.K.Y., Cheung K.M.C. and Luk K.D.K., Micro-architectural and Nano-mechanical Properties of Trabecular Bone with Strontium Treatment in Osteoporotic Goats, 9th Regional Osteoporosis Conference, Hong Kong. 2008. |
|
Li Z., Lu W.W., Chiu P.K.Y., Lam R.W.M., Tang B., Ngan A.H.W., Wong C.T., Fang D., Cheung K.M.C. and Luk K.D.K., Micro-architectural and nano-mechanical properties of trabecular bone with strontium treatment in large animal model of osteoporosis, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2007, 11: S80. |
|
Li Z., Lu W.W., Chiu P.K.Y., Lam R.W.M., Tang B., Ngan A.H.W., Wong C.T., Fang D., Cheung K.M.C. and Luk K.D.K., Micro-architectural and nano-mechanical properties of trabecular bone with strontium treatment in large animal model of osteoporosis, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Li Z., Lu W.W., Chiu P.K.Y., Lam R.W.M., Cheung K.M.C., Tang B., Ngan A.H.W. and Luk K.D.K., Micro-architecture and Nano-mechanics of Lumbar Vertebra with Strontium Treatment in Large Animal Model of Osteoporosis, 54th Annual Meeting of the Orthopaedic Research Society, San Francisco, USA. 2008, P276. |
|
Lie C.W.H., Cheung K.M.C., Fan B.J., Karpinnen J., Leong J.C.Y. and Luk K.D.K., Can age-related intervertebral disc changes be differentiated from degenerative disc disease, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Liu H., Hu Y., Chang C. and Luk K.D.K., Fast extraction of somatosensory evoked potential based on second order blind identification, IEEE EMBS Annual Conference (EMBS2007). 2007. |
|
Liu X.M., Wu S.L., |
|
Liu X.M., Wu S.L., |
|
Lu W.W., Li Z., Chiu P.K.Y., Lam R.W.M., Yang C., Xu B., Wong C.T., Fang D., Cheung K.M.C. and Luk K.D.K., Bone composition and mineral crystal structure after strontium treatment for osteoporosis in goat model, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2007, 11: S79. |
|
Lu W.W., Li Z., Chiu P.K.Y., Lam R.W.M., Yang C., Xu B., Wong C.T., Fang D., Cheung K.M.C. and Luk K.D.K., Bone composition and mineral crystal structure after strontium treatment for osteoporosis in goat model, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Lu W.W., Li Z., Chiu P.K.Y., Lam R.W.M., Cheung K.M.C., Fang D., Leong J.C.Y. and Luk K.D.K., Mineral Crystal Composition and Structure of New Bone after Strontium Treatment for Osteoporosis in Goat Model, 54th Annual Meeting of the Orthopaedic Research Society, San Francisco, USA. 2008, P966. |
|
Lu W.W., Peng S.L., Zhou G., Luk K.D.K., Li Z., Wong C.T., Lam R.W.M. and Cheung K.M.C., Strontium promotes osteogenic differentiation and inhibits the osteoclastogenic potentials in murine mesenchymal stem cells, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Luk K.D.K., Leung Y.L., Hung S.C., Tsui Y.K., Lee M.K., Chan Li L.C., Lo G.G., Masuda K., Wu E.X. and Chan D., Allogeneic mesenchymal stem cell transplantation into the intervertebral disc; effect of severity of degeneration and cell number on regeneration, 15th Triennial Congress of Asia Pacific Orthopaedic Association, Seoul, Korea, September 9-13, 2007. |
|
Luk
K.D.K., Mak
J.N.F. and Hu Y., Application of
surface electromyography in low back pain assessment, Fifth SICOT/SIROT
Annual International Conference, |
|
Luk
K.D.K., Bioactive bone cement for
vertebroplasty, ASEAOA 27- VOA 6- SSHV-12 meeting, |
|
Luk
K.D.K., Biological approach to disc motion
preservation and intervertebral disc transplanation, 50th Anniversary
Celebration of the Orthopaedic Department of |
|
Luk
K.D.K., Disc allograft transplantation, Spine
Arthroplasty Society Asia Pacific Conference 2008, |
|
Luk K.D.K., Editorial: non-fusion surgeries of the cervical spine, Journal of Orthopaedic Surgery. 2008, 16(1): 1-2. |
|
Luk
K.D.K., Etiology and principles of management
of kyphosis, 2nd International Congress of Chinese Orthopaedic
Association, |
|
Luk
K.D.K., Failed back syndrome, ASEAOA 27-
VOA 6- SSHV-12 meeting, |
|
Luk
K.D.K., How I manage cervical myelopathy, AOSpine
Asia Pacific and AOSpine North |
|
Luk
K.D.K., Intervertebral disc transplantation -
from laboratory to clinical trial, 2008 Annual Meeting of sICOT |
|
Luk
K.D.K., Intervertebral disc transplantation -
from laboratory to clinical trial, 2008 Annual Meeting of the |
|
Luk
K.D.K., Intervertebral disc transplantation,
from animal studies to clinical trial, XX Biannual National Congress, |
|
Luk K.D.K., Intervertebral disc transplantation: from animal study to pilot human trial, World Forum for Spine Research - The Interveretegral Disc, First Japanese Meeting, Kyoto, Japan, January 23-26, 2008. |
|
Luk
K.D.K., Intervertebral disc transplantation, Division
of Spine Surgery, The |
|
Luk
K.D.K., Lumbar spine accesses and their
relevant complications, AOSpine Advance Course, |
|
Luk
K.D.K., Management algorithm for failed back
syndrome, Department of Orthopaedic Surgery, |
|
Luk K.D.K., Management of TB of the spine: historical perspective and the future, 6th Annual AOSpine North America Fellows Forum, Banff Spring, Alberta, Canada, April 3-6, 2008. 2008. |
|
Luk
K.D.K., Management of failed back syndrome, 2nd
International Congress of Chinese Orthopaedic Association, |
|
Luk
K.D.K., The approach to failed back syndrome,
XX Biannual National Congress, |
|
Luk K.D.K., The pathomechanism of degenerative spondylolisthesis and the treatment strategy, XX Biannual National Congress, Ankara, Turkey, October 23-28, 2007. 2007. |
|
Luk K.D.K., Trend of basic spinal research in Hong Kong, 7th Combined Congress of the Spine and Pediatric Sections, APOA, Jeju Island, Korea, June 4-7, 2008. |
|
Ng M.C., Ho J.T., Ho S.L., Lee R., Li G., Cheng T.S., Song Y., Ho W.L., Fong C.Y., Mak W., Chan K.H., Li L.S.W., Luk K.D.K., Hu Y., Ramsden D.B. and Leong Fung L.L.Y., Abnormal diffusion tensor in nonsymptomatic familial amyotrophic lateral sclerosis with a causative superoxide dismutase 1 mutation., J Magn Reson Imaging. . 2008, 27(1): 8-13. |
|
Ng M.C., Wu E.X., Lau H.F., Hu Y., Lam E.Y.M. and Luk K.D.K., Cervical spinal cord BOLD fMRI study: Modulation of functional activation by dexterity of dominant and non-dominant hands., Neuroimage. 831, 2008, 39: 825. |
|
Ng M.C., Hua J., van Zijl P., Yang E., Hu Y., Luk K.D.K. and Lam E.Y.M., Magnetization Transfer (MT) asymmetry in human cervical spinal cord, International Society of Magnetic Resonance in Medicine Annual Meeting. 2008, 3404. |
|
Ni G., Lu W.W., Chiu P.K.Y., Wang Y., Li Z., Zhang Y.G., Xu B., Deng L.F. and Luk K.D.K., Mechanical properties of femoral cortical bone following cemented hip replacement, Journal of Orthopaedic Research. 2007, 1408-1414. |
|
Ni G.X., Lu W.W., Tang B., Ngan A.H.W., Chiu K.Y., Cheung K.M.C., Li Z. and Luk K.D.K., Effect Of Weight-bearing
On Bone-bonding Behavior Of Strontium-containing Hydroxyapatite Bone Cement, Journal
Of Biomedical Materials Research Part A. 111 RIVER ST, HOBOKEN, NJ 07030
USA, WILEY-LISS, DIV JOHN WILEY & SONS INC, 2007, |
|
Poon R.W.Y., |
|
Shen
C., Liu H., Xie X., Luk K.D.K. and Hu Y., Selection of floating-point or
fixed-point For Adaptive Noise Canceller In Somatosensory Evoked Potential
Measurement., Annual International Conference of the IEEE Engineering in
Medicine and Biology Society. |
|
Song Y., Ho D.W.H., Karppinen J., Kao P.Y.P., Fan B.J., Luk K.D.K., Yip S.P., Leong J.C.Y., Cheah K.S.E., Sham P.C., Chan D. and Cheung K.M.C., Association between promoter-1607 polymorphism of MMP1 and lumbar disc disease in Southern Chinese, BMC Medical Genetics. 2008, 9(1): 38. |
|
Song Y., Cheung K.M.C., Ho D.W.H., Poon S.C.S., Chiba K., Kawaguchi Y., Hirose Y., Alini M., Grad S., Yee A.F.Y., Leong J.C.Y., Luk K.D.K., Yip S.P., Karppinen J., Cheah K.S.E., Sham P.C., Ikegawa S. and Chan D., Association of the asporin D14 allele with lumbar disc degeneration in Asians, American Journal of Human Genetics. 2008, 82(3): 744-747. |
|
Song Y., Cheung K.M.C., Ho D.W.H., Poon S.C.S., Chiba K., Kawaguchi Y., Hirose Y., Alini M., Grad S., Yee A.F.Y., Leong J.C.Y., Luk K.D.K., Yip S., Karppinen J., Cheah K.S.E., Sham P.C., Ikegawa S. and Chan D., Genetic Risk Factors For Intervertebral Disc Degeneration, 7th Pan Pacific Connective Tissue Societies Symposium 2007 - Shangri-La Resort, Cairns, Australia, 28 October - 1 November 2007. |
|
Song
Y., Chan D., Kao P.Y.P., Ho D.W.H., Fan B., Karpinen J., Yip S.Y., Leong J.C.Y., Luk K.D.K., Ott J., Cheah K.S.E., Sham P.C. and Cheung K.M.C., Three genes in the
aggrecan degradation pathway act synergistically to predispose to
degenerative disc disease., World Forum for Spine Research - The
Intervertebral Disc. |
|
Takemitsu M., Cheung K.M.C., Wong Y.W., Cheung W.Y. and Luk K.D.K., C5 nerve root palsy after cervical laminoplasty and fusion with instrumentation, Journal of Spinal Disorders and Techniques. 2008, 21: 267-272. |
|
Tam W.K., Cheung K.M.C., Chan D., Leong V.Y.L., Luk K.D.K. and Zhou G.Q., Both HIF-1aand HIF-2aare Present in
Prenatal and Postnatal Nucleus., World Forum for Spine Research - The
Intervertebral Disc. |
|
Wong
H.M., Yeung K.W.K., Lam K.O., |
|
Wong K., Cheung K.M.C., Karpinnen J., Fan B.J., Leong J.C.Y. and Luk K.D.K., Relationship between
magnetic resonance imaging changes of the lumbar spine and low back pain: a
magnetic resonance imaging study of 1043 population-based subjects, 27th
Annual Congress of the Hong Kong Orthopaedic Association, |
|
Wong K., Don A.S., Chong C.S., Wong Y.W., Cheung K.M.C. and Luk K.D.K., Selection of fusion levels in adolescent idiopathic scoliosis using fulcrum bending prediction - a prospective study, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Wong Y.W., Lie C.W.H., Cheung K.M.C. and Luk K.D.K., Cervical total vertebrectomy - a case report, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Wong Y.W., Leong J.C.Y. and Luk K.D.K., Direct internal kyphectomy for severe angular tuberculous kyphosis, Clinical Orthopaedics and Related Research. 2007, 460: 124-129. |
|
Wong Y.W., Cheung K.M.C., Cheung W.Y. and Luk K.D.K., Evolution of managing spinal metastasis causing neurological deficit in ten years' period, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Wong Y.W., Cheung W.Y., Cheung K.M.C. and Luk K.D.K., Initial experience in the expansion thoracoplasty for severe congenital scoliosis, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Wong
Y.W., Cheung K.M.C. and Luk K.D.K., Management strategies of
intraoperative haemorrhage from the vertebral artery, 27th Annual Congress
of the Hong Kong Orthopaedic Association, |
|
Wong Y.W., Cheung K.M.C., Cheung W.Y. and Luk K.D.K., Reduction osteotomy or intravertebral structural support for the thoracolumbar osteoporotic fracture - minimal surgery to get maximal stabilization, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Wu S.L., Liu X.M., Chan Y.L., Chung C.Y., |
|
Yang
F., Chan D., Leung Y.L., Lu W.W., Luk K.D.K. and Cheung K.M.C., Dynamic Changes of Type
II Collagen in the Degenerated Murine Discs., World Forum for Spine
Research - The Intervertebral Disc. |
|
Yeung
K.W.K., Chan Y.L., Lama K.O., Wu
S.L., Liu X.M., Chung C.Y., |
|
Yeung
K.W.K., Chan Y.L., Lam K.O., Liu X.M., Wu S.L., Liu X.Y.,
Chung C.Y., Lu W.W., Chan D., Luk K.D.K., |
|
Yeung
K.W.K., Poon R.W.Y., |
|
Zheng Z.M., Luk K.D.K., Kuang G.M., Li Z., Lin J., Lam R.W.M., Cheung K.M.C. and Lu W.W., Vertebral augmentation with a novel vessel-x bone void filling container system and ioactive bone cement, Spine. 2007, 32(19): 2076-2082. |
|
List of Research Outputs |
|
Cheung K.M.C., Wu J.P., Cheng Q.H., Ma S.C., Gao J.C. and Luk K.D.K., Treatment of stiff thoracic scoliosis by thoracoscopic anterior release combined with posterior instrumentation and fusion: a retrospective study, The Journal of Orthopaedic Surgery and Research. 2007, 2(1): 16. |
|
Researcher
: Mak JNF |
|
List of Research Outputs |
|
Hu Y.,
Mak J.N.F., Wong Y.W., Leong J.C.Y. and Luk K.D.K., Quality of life of traumatic
spinal cord injured patients in |
|
Luk
K.D.K., Mak J.N.F. and Hu Y., Application of surface
electromyography in low back pain assessment, Fifth SICOT/SIROT Annual
International Conference, |
|
Researcher
: Ng FY |
|
List of Research Outputs |
|
Ng F.Y., Wong H.L., Yau W.P., Chiu P.K.Y. and Tang W.M., Comparison of range of motion after standard and high-flexion posterior stabilized total knee replacement., International Orthopaedics. 2008, Online publication. |
|
Ng
F.Y., Yau
W.P., Tang W.M. and Chiu P.K.Y., How Accurate Can We
Determine the Rotational Alignment of Femoral Prosthesis in Total Knee
Replacment?, |
|
Ng
F.Y., Yau
W.P., Tang W.M. and Chiu P.K.Y., How accurate can we
determine the rotational alignment of femoral prosthesis in total knee
replacement?, 27th Annual Congress of the Hong Kong Orthopaedic
Association, |
|
Researcher
: Ng KH |
|
List of Research Outputs |
|
Ng
K.H., Negative pressure management of wound, The
4th Asia Pacific Conference on Diabetic Limb Problems, |
|
Researcher
: Ng MC |
|
List of Research Outputs |
|
Ng M.C., Ho J.T., Ho S.L., Lee R., Li G., Cheng T.S., Song Y., Ho W.L., Fong C.Y., Mak W., Chan K.H., Li L.S.W., Luk K.D.K., Hu Y., Ramsden D.B. and Leong Fung L.L.Y., Abnormal diffusion tensor in nonsymptomatic familial amyotrophic lateral sclerosis with a causative superoxide dismutase 1 mutation., J Magn Reson Imaging. . 2008, 27(1): 8-13. |
|
Ng M.C., Wu E.X., Lau H.F., Hu Y., Lam E.Y.M. and Luk K.D.K., Cervical spinal cord BOLD fMRI study: Modulation of functional activation by dexterity of dominant and non-dominant hands., Neuroimage. 831, 2008, 39: 825. |
|
Researcher
: Ng TP |
|
List of Research Outputs |
|
Hsu Y.C., Cheng H.C., Ng T.P. and Chiu P.K.Y., Antibiotic-loaded cement articulating spacer for 2-stage reimplantation in infected total knee arthroplasty - a simple and economic method, The Journal of Arthroplasty. 2007, 22(7): 1060-1066. |
|
Liu
K., Chiu P.K.Y., |
|
Liu K.G., Chiu P.K.Y., |
|
Ng T.P., Miu Y.S., Chiu P.K.Y., Tang W.M. and Yau W.P., Early Experience of Minimally Invasive Surgery Total Knee Arthroplasty Performed with Computer Navigation, Hong Kong Journal of Orthopaedic Surgery. 2007, 11: S44. |
|
Ng
T.P., Miu Y.S. and Chiu P.K.Y., Early experience of
minimally invasive surgery total knee arthroplasty performed with computer
navigation, 27th Annual Congress of the Hong Kong Orthopaedic Association,
|
|
Wong K., Ng T.P. and Chiu P.K.Y., Hip pain after years of hip fusion, Journal of Bone & Joint Surgery (British). 2008, 90B: 510-511. |
|
Yau W.P., Chiu P.K.Y., Tang W.M. and Ng T.P., Comparison of range of motion after standard and hi-flexion posterior stabilized total knee replacement, Proceedings of the 15th Congress of Asia Pacific Orthopaedic Association, Seoul, Korea, September 9-13, 2007. 246-7. |
|
Yau
W.P., Chiu P.K.Y., Tang W.M. and Ng T.P., Comparison of range of
motion after standard and high-flexion posterior stabilized total knee
replacement, 15th Triennial Congress of |
|
Yau
W.P., Chiu P.K.Y., Zuo J., Tang W.M. and Ng T.P., Computer navigation did not
improve alignment in a lower-volume total knee practice , 8th Annual
Meeting of Computer Assisted Orthopaedic Surgery -International Association.
2008, June 5-7, |
|
Yau
W.P., Chiu P.K.Y., Yan C.H., Tang W.M. and Ng T.P., What have I learned after
adopting computer navigation in total knee replacement?, 5th Annual
Meeting of Asian Society for Computer Assisted Orthopaedic Surgery. 2008,
June 4, |
|
Researcher
: Ni G |
|
List of Research Outputs |
|
Li Z., Yang C., Lu W.W., Xu B., Lam R.W.M., Ni G., Abbah S.A., Yang F., Cheung K.M.C. and Luk K.D.K., Characteristics and mechanical properties of acrylolpamidronate-treated strontium containing bioactive bone cement, J Biomed Mater Res B Appl Biomater. 2007, 83(2): 464-71. |
|
Ni G., Lu W.W., Chiu P.K.Y., Wang Y., Li Z., Zhang Y.G., Xu B., Deng L.F. and Luk K.D.K., Mechanical properties of femoral cortical bone following cemented hip replacement, Journal of Orthopaedic Research. 2007, 1408-1414. |
|
Researcher
: Pan H |
|
List of Research Outputs |
|
Pan
H., Li Z.,
Lam R.W.M., Wong C.T. and Lu W.W., Solubility study of 10% Sr-Hap
and the effect of strontium by solid titration, 1st asian biomaterials
congress, |
|
Researcher
: Peng SL |
|
List of Research Outputs |
|
Lu W.W., Peng S.L., Zhou G., Luk K.D.K., Li Z., Wong C.T., Lam R.W.M. and Cheung K.M.C., Strontium promotes osteogenic differentiation and inhibits the osteoclastogenic potentials in murine mesenchymal stem cells, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Researcher
: Shen C |
|
List of Research Outputs |
|
Shen
C., Liu
H., Xie X., Luk K.D.K. and Hu Y., Selection of floating-point or
fixed-point For Adaptive Noise Canceller In Somatosensory Evoked Potential
Measurement., Annual International Conference of the IEEE Engineering in
Medicine and Biology Society. |
|
Researcher
: Tang WM |
|
Project Title: |
The alteration of CIP1/WAF1 gene in osteosarcoma: correlation with bone destruction, p53 expression, cell proliferation, cell cycle and clinical data |
|
Investigator(s): |
Tang WM, Chung SSM, Chiu PKY, Liao WM, Chow SP |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
University Research Committee / Committee on Research and Conference Grants - General Award |
|
Start Date: |
07/1997 |
|
Abstract: |
|
To investigate the role of the tumour suppressor gene: CIP1/WAF1 on the pathogenesis and aggressiveness on osteosarcoma; to examine the behaviour of osteosarcoma at the molecular level. |
|
Project Title: |
Enhancement of experimental fracture healing in using tradition Chinese medicine |
|
Investigator(s): |
Tang WM, |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Low Budget High Impact Programme |
|
Start Date: |
11/2001 |
|
Abstract: |
|
To determine the effect of these TCM prescriptions on fracture healing in a experimental fracture animal model. |
|
List of Research Outputs |
|
Fang
D., Chiu P.K.Y., Tang W.M. and Fang C., Asian total
hip system: Clinical and radiological results at 11 years, 15th Triennial
Congress of |
|
Fang D., Chiu P.K.Y., Tang W.M. and Fang C., Asian total hip system: clinical and radiological results at 11 years, Proceedings of the 15th Congress of Asia Pacific Orthopaedic Association, Seoul, Korea, September 9-13, 2007. 226. |
|
Ho Y.W., Yeung J.S.L., Chiu P.K.Y., Tang W.M., Lin Z.B., Man R.Y.K. and Lau W.C.S., Ganoderma lucidum polysaccharide peptide reduced the production of pro-inflammatory cytokines in activated rheumatoid synovial fibroblast, Molecular & Cellular Biochemistry. 2007, 301(1-2): 173-179. |
|
Liu
K., Chiu P.K.Y., |
|
Liu K.G., Chiu P.K.Y., |
|
Ng F.Y., Wong H.L., Yau W.P., Chiu P.K.Y. and Tang W.M., Comparison of range of motion after standard and high-flexion posterior stabilized total knee replacement., International Orthopaedics. 2008, Online publication. |
|
Ng
F.Y., Yau W.P., Tang W.M. and Chiu P.K.Y., How Accurate Can We
Determine the Rotational Alignment of Femoral Prosthesis in Total Knee
Replacment?, |
|
Ng
F.Y., Yau W.P., Tang W.M. and Chiu P.K.Y., How accurate can we
determine the rotational alignment of femoral prosthesis in total knee
replacement?, 27th Annual Congress of the Hong Kong Orthopaedic
Association, |
|
Ng J.K.F., Lawmin J.C., Li C.F., Tsang S.F., Tang W.M. and Chiu P.K.Y., Comprehensive evaluation of platelet dysfunction in patients taking diclofenac before joint arthroplasties, Journal of Arthroplasty. 2008, 23: 424-430. |
|
Ng J.K.F., Lawmin J.C., Li C.C.F., Tsang S.F., Tang W.M. and Chiu P.K.Y., Comprehensive preoperative evaluation of platelet function in total knee arthroplasty patients taking diclofenac., J Arthroplasty. 2008, 23: 424-30. |
|
Ng J.K.F., Lawmin J.C., Tsang S.F., Tang W.M. and Chiu P.K.Y., PFA-100 closure times and blood loss during total knee arthroplasty in patients taking NSAIDs, HAA 2007 Combined Annual Scientific Meeting of the Haematology Society of Australia & New Zealand, the Australian & New Zealand Society of Blood Transfusion, and the Australasian Society of Thrombosis & Haemostasis. 2007. |
|
Ng J.K.F., Lawmin J.C., Tsang S.F., Tang W.M. and Chiu P.K.Y., PFA-100 closure times and postoperative blood loss after total knee arthroplasty in patients taking NSAIDs, XXIst International Symposium on Technological Innovations in Laboratory Hematology, Sydney Convention Centre, Sydney, Australia, April 28 - May 1, 2008. |
|
Ng
J.K.F., Lawmin J.C., Tsang S.F., Tang W.M. and Chiu P.K.Y., PFA-100 closure times and postoperative blood loss after total knee
arthroplasty in patients taking NSAIDs, Int J Lab Hematol 2008. 30
Suppl1: |
|
Ng T.P., Miu Y.S., Chiu P.K.Y., Tang W.M. and Yau W.P., Early Experience of Minimally Invasive Surgery Total Knee Arthroplasty Performed with Computer Navigation, Hong Kong Journal of Orthopaedic Surgery. 2007, 11: S44. |
|
Tang
W.M. and Chiu
P.K.Y., Cementing new liner into well fixed cementless cup, 15th
Triennial Congress of |
|
Tang
W.M. and Chiu
P.K.Y., Cementing new liner into well fixed cementless cup, 27th
Annual Congress of the Hong Kong Orthopaedic Association, |
|
Tang
W.M. and Chiu
P.K.Y., Cementing new liner into well fixed cementless cup, Proceedings
of the 15th Congress of Asia Pacific Orthopaedic Association, |
|
Tang W.M. and Chiu P.K.Y., Letter to editor: Variances in sagittal femoral shaft bowing in patterns undergoing TKA, Clinical Orthopeadics & Related Research. 2008, 466(4): 1008-9. |
|
Tang W.M., In: Tang Wai Man, ORTHOPEDICS. 2008. |
|
Tang
W.M. and Chiu
P.K.Y., Poster: Sagittal pelvic Mal-rotation and positioning of the
acetabular component, 15th Triennial Congress of |
|
Tang
W.M. and Chiu
P.K.Y., Sagittal bowing of the distal femur in Chinese patients, 15th
Triennial Congress of |
|
Tang
W.M. and Chiu
P.K.Y., Sagittal bowing of the distal femur in Chinese patients, Proceedings
of the 15th Congress of Asia Pacific Orthopaedic Association, |
|
Tang
W.M. and Chiu
P.K.Y., Sagittal pelvic mal-rotation and positioning of the acetabular
component, Proceedings of the 15th Congress of Asia Pacific Orthopaedic
Association, |
|
Wong K.L., Tang W.M., Lu W.W., Cheung W.L. and Chiu P.K.Y., Mechanical properties of polyetheretherketone-strontium hydroxyapatite composites , 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2007, 11: S111. |
|
Yau W.P., Chiu P.K.Y., Tang W.M. and Ng T.P., Comparison of range of motion after standard and hi-flexion posterior stabilized total knee replacement, Proceedings of the 15th Congress of Asia Pacific Orthopaedic Association, Seoul, Korea, September 9-13, 2007. 246-7. |
|
Yau
W.P., Chiu P.K.Y., Tang W.M. and Ng T.P., Comparison of range of motion
after standard and high-flexion posterior stabilized total knee replacement, 15th
Triennial Congress of |
|
Yau
W.P., Chiu P.K.Y., Zuo J., Tang W.M. and Ng T.P., Computer navigation did not
improve alignment in a lower-volume total knee practice , 8th Annual
Meeting of Computer Assisted Orthopaedic Surgery -International Association.
2008, June 5-7, |
|
Yau W.P., Chiu P.K.Y. and Tang W.M., Computer navigation did not improve alignment in a lower-volume total knee practice, Clinical Orthopaedic Related Research. 2008, 466: 935-945. |
|
Yau W.P., Chiu P.K.Y. and Tang W.M., How Precise is the Determination of Rotational Alignment of the Femoral Prosthesis in Total Knee Arthroplasty. An in vivo Study., Journal of Arthroplasty. 2007, 22: 1042-1048. |
|
Yau
W.P., Chiu P.K.Y., Yan C.H., Tang W.M. and Ng T.P., What have I learned after
adopting computer navigation in total knee replacement?, 5th Annual
Meeting of Asian Society for Computer Assisted Orthopaedic Surgery. 2008,
June 4, |
|
List of Research Outputs |
|
Luk K.D.K., Leung Y.L., Hung S.C., Tsui Y.K., Lee M.K., Chan Li L.C., Lo G.G., Masuda K., Wu E.X. and Chan D., Allogeneic mesenchymal stem cell transplantation into the intervertebral disc; effect of severity of degeneration and cell number on regeneration, 15th Triennial Congress of Asia Pacific Orthopaedic Association, Seoul, Korea, September 9-13, 2007. |
|
Tsui
Y.K., Leung
Y.L., Kao R.Y.T., Chan D., Masuda K. and Cheung K.M.C., High throughput screening
of chemical compounds for the treatment of osteoarthritis, Best Poster
Award, 12th Ressearch Postgraduate Symposium, The |
|
Tsui
Y.K., Leung
Y.L., Kao R.Y.T., Chan D., Masuda
K. and Cheung K.M.C., Identification
of Chemical Compounds for the Treatment of Intervertebral Disc Degeneration
with the Application of High-throughput Screening, World Forum for Spine
Research - The Intervertebral Disc. |
|
Researcher
: Wang Y |
|
List of Research Outputs |
|
Ni G., Lu W.W., Chiu P.K.Y., Wang Y., Li Z., Zhang Y.G., Xu B., Deng L.F. and Luk K.D.K., Mechanical properties of femoral cortical bone following cemented hip replacement, Journal of Orthopaedic Research. 2007, 1408-1414. |
|
Wang Y., Deng Y. and Zhou G., SDF-1alpha/CXCR4-mediated migration of systemically transplanted bone marrow stromal cells towards ischemic brain lesion in a rat model, Brain Research. 2008, 1195: 1104-1112. |
|
Researcher
: Wang Y |
|
List of Research Outputs |
|
Ni G., Lu W.W., Chiu P.K.Y., Wang Y., Li Z., Zhang Y.G., Xu B., Deng L.F. and Luk K.D.K., Mechanical properties of femoral cortical bone following cemented hip replacement, Journal of Orthopaedic Research. 2007, 1408-1414. |
|
Wang Y., Deng Y. and Zhou G., SDF-1alpha/CXCR4-mediated migration of systemically transplanted bone marrow stromal cells towards ischemic brain lesion in a rat model, Brain Research. 2008, 1195: 1104-1112. |
|
List of Research Outputs |
|
Lam R.W.M., Wong C.T., Li Z., Luk K.D.K., Chan W.K., Yang C., Chiu P.K.Y., Xu B. and Lu W.W., Solvothermal synthesis of strontium phosphate chloride nanowire, Journal of Cystal Growth. 2007, 306: 129-134. |
|
Lam W.M.R., Wong C.T., Li Z., Luk K.D.K., Chan W.K., Yang C., Chiu P.K.Y., Xu B. and Lu W.W., Solvothermal synthesis of strontium phosphate chloride nanowire., Journal of Crystal Growth. 2007, 306 (1): 129-134. |
|
Li Z., Lu W.W., Chiu P.K.Y., Lam R.W.M., Tang B., Ngan A.H.W., Wong C.T., Fang D., Cheung K.M.C. and Luk K.D.K., Micro-architectural and nano-mechanical properties of trabecular bone with strontium treatment in large animal model of osteoporosis, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2007, 11: S80. |
|
Li Z., Lu W.W., Chiu P.K.Y., Lam R.W.M., Tang B., Ngan A.H.W., Wong C.T., Fang D., Cheung K.M.C. and Luk K.D.K., Micro-architectural and nano-mechanical properties of trabecular bone with strontium treatment in large animal model of osteoporosis, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Lu W.W., Li Z., Chiu P.K.Y., Lam R.W.M., Yang C., Xu B., Wong C.T., Fang D., Cheung K.M.C. and Luk K.D.K., Bone composition and mineral crystal structure after strontium treatment for osteoporosis in goat model, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2007, 11: S79. |
|
Lu W.W., Li Z., Chiu P.K.Y., Lam R.W.M., Yang C., Xu B., Wong C.T., Fang D., Cheung K.M.C. and Luk K.D.K., Bone composition and mineral crystal structure after strontium treatment for osteoporosis in goat model, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Lu W.W., Peng S.L., Zhou G., Luk K.D.K., Li Z., Wong C.T., Lam R.W.M. and Cheung K.M.C., Strontium promotes osteogenic differentiation and inhibits the osteoclastogenic potentials in murine mesenchymal stem cells, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Pan
H., Li Z., Lam R.W.M., Wong C.T. and Lu W.W., Solubility study of 10% Sr-Hap
and the effect of strontium by solid titration, 1st asian biomaterials
congress, |
|
Wong C.T., Lecture Title: Bone Cement and its clinical application., Course Title: Biomedical materials: From engineering to clinical applications (AP4173 & AP8173), Department of Physics and Materials Science, City University of Hong Kong. 2007. |
|
Researcher
: Wong HM |
|
List of Research Outputs |
|
Wong
H.M., Yeung
K.W.K., Lam K.O., |
|
Researcher
: Wong JWK |
|
List of Research Outputs |
|
Wong
J.W.K., Yip
D.K.H. and Yau W.P., Preparation
of Graft in Double-Bundle Anterior Cruciate Ligament Reconstruction, |
|
Researcher
: Wong KL |
|
List of Research Outputs |
|
Wong K.L., Tang W.M., Lu W.W., Cheung W.L. and Chiu P.K.Y., Mechanical properties of polyetheretherketone-strontium hydroxyapatite composites , 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2007, 11: S111. |
|
Researcher
: Wong YW |
|
List of Research Outputs |
|
Cheung K.M.C., Cheng A.C.S., Cheung W.Y., Chooi Y.S., Wong Y.W. and Luk K.D.K., Right hip adduction deficit is prevalent in patients with adolescent idiopathic scoliosis, Journal of Orthopaedic Surgery. 2008, 16(1): 24-26. |
|
Cheung W.Y., Arvinte D., Wong Y.W., Luk K.D.K. and Cheung K.M.C., Neurological recovery after surgical decompression in patients with cervical spondylotic myelopathy - a prospective study, International Orthopaedics. 2008, 32(2): 273-278. |
|
Hu Y., Ding Y., Yuan D., Wong Y.W., Cheung K.M.C. and Luk K.D.K., Prognostic value of somatosensory-evoked potentials in the surgical management of cervical spondylotic myelopathy, Spine. 2008, 33: E305-10. |
|
Hu Y.,
Mak J.N.F., Wong Y.W., Leong J.C.Y. and Luk K.D.K., Quality of life of traumatic
spinal cord injured patients in |
|
Takemitsu M., Cheung K.M.C., Wong Y.W., Cheung W.Y. and Luk K.D.K., C5 nerve root palsy after cervical laminoplasty and fusion with instrumentation, Journal of Spinal Disorders and Techniques. 2008, 21: 267-272. |
|
Wong K., Don A.S., Chong C.S., Wong Y.W., Cheung K.M.C. and Luk K.D.K., Selection of fusion levels in adolescent idiopathic scoliosis using fulcrum bending prediction - a prospective study, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Wong Y.W., Lie C.W.H., Cheung K.M.C. and Luk K.D.K., Cervical total vertebrectomy - a case report, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Wong Y.W., Leong J.C.Y. and Luk K.D.K., Direct internal kyphectomy for severe angular tuberculous kyphosis, Clinical Orthopaedics and Related Research. 2007, 460: 124-129. |
|
Wong Y.W., Cheung K.M.C., Cheung W.Y. and Luk K.D.K., Evolution of managing spinal metastasis causing neurological deficit in ten years' period, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Wong Y.W., Cheung W.Y., Cheung K.M.C. and Luk K.D.K., Initial experience in the expansion thoracoplasty for severe congenital scoliosis, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Wong
Y.W., Cheung
K.M.C. and Luk K.D.K., Management
strategies of intraoperative haemorrhage from the vertebral artery, 27th
Annual Congress of the Hong Kong Orthopaedic Association, |
|
Wong Y.W., Cheung K.M.C., Cheung W.Y. and Luk K.D.K., Reduction osteotomy or intravertebral structural support for the thoracolumbar osteoporotic fracture - minimal surgery to get maximal stabilization, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Researcher
: Yang F |
|
List of Research Outputs |
|
Li Z., Yang C., Lu W.W., Xu B., Lam R.W.M., Ni G., Abbah S.A., Yang F., Cheung K.M.C. and Luk K.D.K., Characteristics and mechanical properties of acrylolpamidronate-treated strontium containing bioactive bone cement, J Biomed Mater Res B Appl Biomater. 2007, 83(2): 464-71. |
|
Yang
F., Chan
D., Leung Y.L., Lu W.W., Luk K.D.K. and Cheung K.M.C., Dynamic Changes of Type
II Collagen in the Degenerated Murine Discs., World Forum for Spine
Research - The Intervertebral Disc. |
|
Researcher
: Yau WP |
|
List of Research Outputs |
|
Liu
K., Chiu P.K.Y., |
|
Liu K.G., Chiu P.K.Y., |
|
Ng F.Y., Wong H.L., Yau W.P., Chiu P.K.Y. and Tang W.M., Comparison of range of motion after standard and high-flexion posterior stabilized total knee replacement., International Orthopaedics. 2008, Online publication. |
|
Ng
F.Y., Yau W.P., Tang W.M. and Chiu P.K.Y., How Accurate Can We
Determine the Rotational Alignment of Femoral Prosthesis in Total Knee
Replacment?, |
|
Ng
F.Y., Yau W.P., Tang W.M. and Chiu P.K.Y., How accurate can we
determine the rotational alignment of femoral prosthesis in total knee
replacement?, 27th Annual Congress of the Hong Kong Orthopaedic
Association, |
|
Ng T.P., Miu Y.S., Chiu P.K.Y., Tang W.M. and Yau W.P., Early Experience of Minimally Invasive Surgery Total Knee Arthroplasty Performed with Computer Navigation, Hong Kong Journal of Orthopaedic Surgery. 2007, 11: S44. |
|
Wong
J.W.K., Yip D.K.H. and Yau W.P., Preparation of Graft in
Double-Bundle Anterior Cruciate Ligament Reconstruction, |
|
Yau
W.P., Assessment Tools in Sports Medicine –
Myth or Evidence?, Didactic Lecture on Sports Medicine (organized by Hong
Kong |
|
Yau
W.P., Leung A., Liu K.G., Yan C.H. and Chiu P.K.Y., Can minimal incision
approach be combined with computer assisted navigation total knee
replacement? - a cadaveric study, Proceedings of the 15th Congress of Asia
Pacific Orthopaedic Association, |
|
Yau
W.P., Leung A., Liu K., Yan C.H. and Chiu P.K.Y., Can minimal incision
approach be combined with computer assisted navigation total knee
replacement? – A cadaveric study, 15th Triennial Congress of |
|
Yau W.P., Chiu P.K.Y., Tang W.M. and Ng T.P., Comparison of range of motion after standard and hi-flexion posterior stabilized total knee replacement, Proceedings of the 15th Congress of Asia Pacific Orthopaedic Association, Seoul, Korea, September 9-13, 2007. 246-7. |
|
Yau
W.P., Chiu
P.K.Y., Tang W.M. and Ng T.P., Comparison of range of motion
after standard and high-flexion posterior stabilized total knee replacement, 15th
Triennial Congress of |
|
Yau
W.P., Chiu
P.K.Y. and Fok M., Computer Navigated Articulated Cement Spacers (IGS
PROSTALAC) for Infected Total Knee Replacement, |
|
Yau
W.P., Chiu
P.K.Y. and Fok M., Computer navigated articulated cement spacers (IGS
prostalac) for infected total knee replacement, 27th Annual Congress of
the Hong Kong Orthopaedic Association, |
|
Yau
W.P., Chiu
P.K.Y., Zuo J., Tang W.M. and Ng T.P., Computer navigation did not
improve alignment in a lower-volume total knee practice , 8th Annual
Meeting of Computer Assisted Orthopaedic Surgery -International Association.
2008, June 5-7, |
|
Yau W.P., Chiu P.K.Y. and Tang W.M., Computer navigation did not improve alignment in a lower-volume total knee practice, Clinical Orthopaedic Related Research. 2008, 466: 935-945. |
|
Yau W.P. and Chiu P.K.Y., Cutting Errors in Total Knee Replacement: Assessment by Computer Assisted Surgery., Knee Surgery, Sports Traumatology, Arthroscopy. 2008, 16(7): 670-673. |
|
Yau
W.P., Chiu
P.K.Y. and Yan C.H., Cutting Errors in Total Knee Replacement, |
|
Yau
W.P., Chiu
P.K.Y. and Yan C.H., Cutting errors in total knee replacement, 27th
Annual Congress of the Hong Kong Orthopaedic Association, |
|
Yau
W.P., Liu
K., Yan C.H. and Chiu P.K.Y.,
Errors in Identification of the Distal Femur Transepicondylar and Anterior
Posterior Axes in Minimal Incision TKR and Conventional Incision TKR Using
Image Free Computer Navigation System, 8th Annual Meeting of Computer
Assisted Orthopaedic Surgery -International Association. 2008, June 5-7, |
|
Yau
W.P. and Chiu
P.K.Y., Errors in Identification of the Distal Femur Transepicondylar and
Anterior Posterior Axes in Minimal Incision Total Knee Replacement and
Conventional Incision Total Knee Replacement – A Cadaveric Study, 27th
Annual Congress of the |
|
Yau
W.P. and Chiu
P.K.Y., Errors in Identification of the Distal Femur Transepicondylar and
Anterior Posterior Axes in Minimal Incision Total Knee Replacement and
Conventional Incision Total Knee Replacement – A Cadaveric Study, |
|
Yau W.P., Leung A., Liu K.G., Yan C.H., Wong L.L.S. and Chiu P.K.Y., Errors in identification of the distal femur transepicondylar and anterior posterior axes in minimal incision total knee replacement and conventional incision total knee replacement - a cadaveric study, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2007, 11: S40. |
|
Yau W.P., Leung A., Liu K.G., Yan C.H., Wong L.S. and Chiu P.K.Y., Errors in the identification of the transepicondylar and anteroposterior axes of the distal femur in total knee replacement using minimally-invasive and conventional approaches: A cadaver study, The Journal of Bone & Joint Surgery (Br). 2008, 90-B: 520-526. |
|
Yau W.P., Chiu P.K.Y. and Tang W.M., How Precise is the Determination of Rotational Alignment of the Femoral Prosthesis in Total Knee Arthroplasty. An in vivo Study., Journal of Arthroplasty. 2007, 22: 1042-1048. |
|
Yau W.P., Leung A., Liu K.G., Yan C.H., Wong L.L.S. and Chiu P.K.Y., Interobserver and intra-observer errors in obtaining visually selected anatomical landmarks during registration process in non-image-based navigation-assisted total knee arthroplasty, The Journal of Arthroplasty. 2007, 22(8): 1150-1161. |
|
Yau
W.P., |
|
Yau
W.P. and Chiu
P.K.Y., Prospective Randomized Controlled Trial Comparing |
|
Yau
W.P. and Chiu
P.K.Y., Prospective Randomized Controlled Trial Comparing |
|
Yau
W.P. and Chiu
P.K.Y., Prospective Randomized Controlled Trial Comparing |
|
Yau
W.P. and Chiu
P.K.Y., Prospective randomised controlled trial comparing range of motion
after standard and high-flexion posterior stabilised total knee prosthesis, 27th
Annual Congress of the Hong Kong Orthopaedic Association, |
|
Yau
W.P. and Chiu
P.K.Y., Radiographic Alignment of the Implanted Prosthesis in Computer
Navigation Total Knee Replacement – A Case Control Study, 27th Annual
Congress of the |
|
Yau
W.P. and Chiu
P.K.Y., Radiographic Alignment of the Implanted Prosthesis in Computer
Navigation Total Knee Replacement – A Case Control Study, |
|
Yau W.P. and Chiu P.K.Y., Radiographic alignment of the implanted prosthesis in computer navigation total knee replacement - a case control study, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2007, 11: S39. |
|
Yau W.P., Sports and Arthroscopy, Preparatory Course for HKCOS / FRCS (Orth) Examination – 2008, April 14 – 18, 2008, Lecture Hall, Duchess of Kent Children Hospital, Hong Kong.. 2008. |
|
Yau
W.P., Chiu
P.K.Y., Yan C.H., Tang W.M. and Ng T.P., What have I learned after
adopting computer navigation in total knee replacement?, 5th Annual
Meeting of Asian Society for Computer Assisted Orthopaedic Surgery. 2008,
June 4, |
|
Researcher
: Yee AFY |
|
List of Research Outputs |
|
Aladin
Kaderbatcha D.M., Cheung K.M.C., Chan D., Yee A.F.Y., Jim J.J.T., Luk K.D.K. and Lu W.W., Expression of the Trp2 allele
of COL |
|
Cheung K.M.C., Song Y., Ho D.W.H., Poon S.C.S., Chiba K., Kawaguchi Y., Hirose Y., Alini M., Grad S., Yee A.F.Y., Leong J.C.Y., Luk K.D.K., Yip S.P., Karppinen J., Cheah K.S.E., Sham P.C., Ikegawa S. and Chan D., Association of the asporin D14 allele with lumbar disc degeneration, Spineweek 2008, Geneva, Switzerland, May 26-31, 2008. |
|
Song Y., Cheung K.M.C., Ho D.W.H., Poon S.C.S., Chiba K., Kawaguchi Y., Hirose Y., Alini M., Grad S., Yee A.F.Y., Leong J.C.Y., Luk K.D.K., Yip S.P., Karppinen J., Cheah K.S.E., Sham P.C., Ikegawa S. and Chan D., Association of the asporin D14 allele with lumbar disc degeneration in Asians, American Journal of Human Genetics. 2008, 82(3): 744-747. |
|
Yee
A.F.Y., Melhado
I.G., Cheah K.S.E., Chan D. and Cheung K.M.C., Use of tandem mass
spectrometry as a tool for proteomics studies in aging and degeneration
processes of the intervertebral disc, Spineweek 2008, |
|
Researcher
: Yeung KWK |
|
List of Research Outputs |
|
Chan
Y.L., Wu S.L., Liu X.M., |
|
Cheung K.M.C., Cheng Y.L., Chan C.W., Yeung K.W.K. and Luk K.D.K., Outcome assessment of braciing in adolescent idiopathic scoliosis by the use of the SRS-22 questionnaire, International Orthopaedics. 2007, 31(4): 507-511. |
|
Lam
K.O., Yeung K.W.K., Chan Y.L., Wu S.L., Liu X.M., Chung
C.Y., |
|
Liu X.M., Wu S.L., |
|
Liu X.M., Wu S.L., |
|
Poon R.W.Y., |
|
Wong
H.M., Yeung K.W.K., Lam K.O., |
|
Wu S.L., Liu X.M., Chan Y.L., Chung C.Y., |
|
Yeung
K.W.K., Chan
Y.L., Lama K.O., Wu S.L., Liu X.M., Chung C.Y., |
|
Yeung
K.W.K., Chan
Y.L., Lam K.O., Liu X.M., Wu
S.L., Liu X.Y., Chung C.Y., Lu W.W., Chan D., Luk K.D.K., |
|
Yeung
K.W.K., Poon R.W.Y., |
|
Researcher
: Yeung Y |
|
List of Research Outputs |
|
Yeung
Y. and Leung
K.L., Surgical treatment of unstable pertrochanteric fracture with
proximal femoral nail: Report of a new radiological complication and its
implication in Chinese hip, The 27th Hong Kong Orthopaedic Association Annual
Congress, |
|
Researcher
: Yip DKH |
|
Project Title: |
To evaluate biomechanically the strongest host bone and allograft bone docking site geometry - for application in bone transplant patients undergoing limb salvage surgery |
|
Investigator(s): |
Yip DKH, Chien EP |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Low Budget High Impact Programme |
|
Start Date: |
11/2000 |
|
Abstract: |
|
To find the strongest, bone docking site geometry between the host bone and massive bone allograft in limb salvage patients. |
|
Project Title: |
Biomechanical evaluation of the effect of incomplete cortical erosion of a diaphyseal long bone |
|
Investigator(s): |
Yip DKH |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2002 |
|
Abstract: |
|
To determine the critical failure strength of a diaphyseal long bone which has been eroded by metastatic disease? |
|
Project Title: |
Strength reduction of suture due to abrasion of the interference screw |
|
Investigator(s): |
Yip DKH |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Small Project Funding |
|
Start Date: |
11/2004 |
|
Abstract: |
|
To compare the failure strength of two types of sutures before and after the abrasive wear by the screw against bone. |
|
List of Research Outputs |
|
Wong
J.W.K., Yip D.K.H. and Yau W.P., Preparation of Graft in
Double-Bundle Anterior Cruciate Ligament Reconstruction, |
|
Researcher
: Yuen CK |
|
List of Research Outputs |
|
Ip
W.Y. and Yuen C.K.,
Implant for Tissue |
|
Yuen C.K. and Ip W.Y., Biodegradable Magnesium Alloys For Tissue Engineering And Other Biological Applications: Unexpected Findings From Mouse Model , 2008 Annual Termis-eu Meeting. 2008. |
|
Yuen C.K. and Ip W.Y., Findings From An Accelerated In Vivo Corrosion Model Of Magnesium, Nature Proceedings. 2008, 10: 1833. |
|
Yuen C.K. and Ip W.Y., Resorbable Metallic Implant: Findings From An Animal Model, Advanced Materials Research. 2008, 47-50: 604-607. |
|
Yuen C.K. and Ip W.Y., Resorbable
Metallic Implant: Finginds From An Animal Model, In: CK |
|
Zhou
W., Wang M., Cheung W.L., Yuen C.K. and Ip W.Y., Selective laser sintered
Meso-porous PLLA and PLLA/CHAp nanocomposite scaffolds for bone tissue
engineering, Proceedings of the 8th World Biomaterials Congress. |
|
Researcher
: Yuen CK |
|
List of Research Outputs |
|
Ip
W.Y. and Yuen C.K.,
Implant for Tissue |
|
Yuen C.K. and Ip W.Y., Biodegradable Magnesium Alloys For Tissue Engineering And Other Biological Applications: Unexpected Findings From Mouse Model , 2008 Annual Termis-eu Meeting. 2008. |
|
Yuen C.K. and Ip W.Y., Findings From An Accelerated In Vivo Corrosion Model Of Magnesium, Nature Proceedings. 2008, 10: 1833. |
|
Yuen C.K. and Ip W.Y., Resorbable Metallic Implant: Findings From An Animal Model, Advanced Materials Research. 2008, 47-50: 604-607. |
|
Yuen C.K. and Ip W.Y., Resorbable
Metallic Implant: Finginds From An Animal Model, In: CK |
|
Zhou
W., Wang M., Cheung W.L., Yuen C.K. and Ip W.Y., Selective laser sintered
Meso-porous PLLA and PLLA/CHAp nanocomposite scaffolds for bone tissue
engineering, Proceedings of the 8th World Biomaterials Congress. |
|
Researcher
: Zhao F |
|
List of Research Outputs |
|
Abbah S.A., Lu W.W., Chan D., Cheung K.M.C., Zhao F., Li Z., Leong J.C.Y. and Luk K.D.K., Osteogenic behavior of alginate encapsulated bone marrow stromal cells: an in vitro study, J Mater Sci Mater Med. 2008, 19(5): 2113-9. |
|
Researcher
: Zhao X |
|
List of Research Outputs |
|
Zhao X., Liu W., Chen D., Lin X. and Lu W.W., Effect of Block Order of ABA- and BAB-Type NIPAAm/HEMA Triblock Copolymers on Thermoresponsive Behavior of Solutions, Macromolecular Chemistry and Physics. 2007, 208: 1773-1781. |
|
Researcher
: Zhou G |
|
Project Title: |
Deciphering the roles of hypoxia-inducible factors in survial and function of intervertebral disc cells |
|
Investigator(s): |
Zhou G, Cheung KMC, Luk KDK, Chan D |
|
Department: |
Orthopaedics and Traumatology |
|
Source(s) of Funding: |
Seed Funding Programme for Basic Research |
|
Start Date: |
03/2007 |
|
Abstract: |
|
Hypoxia-inducible factors (HIFs) function
as a master regulator of oxygen homeostasis in metazoan species. HIFs mediate
changes in gene transcription in response to changes in cellular oxygenation.
Many physiological, pathological, and developmental processes are regulated
by the HIF-related pathways. Accumulating evidences suggest that the HIF
pathway plays critical roles in a number musculoskeletal differention and
diseases but little is known about the role of this pathway in regulating
properties and functions of intervertebral disc cells. Degenerative disorders
of the intervertebral disc are common in elderly people wherein the disc
cells decline in both number and activity. This proposal is therefore
desigened to test our hypothesis that the HIFs-mediated mechanism plays a central
role in regulating the survival and functions of intervertebral disc cells
under extremely hypoxic conditions in nature, and the manipulation of this
pathway will facilitate mesenchymal stem cells to differentiate into disc
cell lineages. Accordingly, the particular aims of the proposal are: 1) to
characterize the growth properties of disc cell populations isolated from rat
and humans and cultured in vitro under normoxia and hypoxia; 2) to
investigate the expression pattern of the hypoxia/VHL/HIF axis-related
molecules in healthy and degenerative intervertebral discs from newborn,
young, adult and aged individuals; 3) to analyze the roles of HIF |
|
List of Research Outputs |
|
Lu W.W., Peng S.L., Zhou G., Luk K.D.K., Li Z., Wong C.T., Lam R.W.M. and Cheung K.M.C., Strontium promotes osteogenic differentiation and inhibits the osteoclastogenic potentials in murine mesenchymal stem cells, 27th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 17-18, 2007. |
|
Wang Y., Deng Y. and Zhou G., SDF-1alpha/CXCR4-mediated migration of systemically transplanted bone marrow stromal cells towards ischemic brain lesion in a rat model, Brain Research. 2008, 1195: 1104-1112. |
|
Xie H., Yang F., Deng L., Luo J., Qin T., Li X., Zhou G. and Yang Z., The Performance of a Bone-derived Scaffold Material in The Repair of Critical Bone Defects in a Rhesus Monkey Model, In: Editor-in-Chief: D.F. Williams, Biomaterials. Elsevier, 2007, 28 (22): 3314-3324. |
|
Zhou
G., SOX9 accelerates osteogenic and
chondrogenic differentiation through multilevel synergies with the PKA
Pathway, The 54th Annual Meeting of the Orthopaedic Research Society, |
|
Zhou G., Webster Jee Investigator Award, International Chinese Hard Tissue Society. 国际华人骨科学会, 2008. |
|
Researcher
: Zuo J |
|
List of Research Outputs |
|
Yau
W.P., Chiu P.K.Y., Zuo J., Tang W.M. and Ng T.P., Computer navigation did not
improve alignment in a lower-volume total knee practice , 8th Annual
Meeting of Computer Assisted Orthopaedic Surgery -International Association.
2008, June 5-7, |
-- End of Listing --