DENTAL FACULTY

Researcher : Al KAAA

List of Research Outputs

 

Rabie A.B.M. and Al K.A.A.A., Does the degree of advancement during functional appliance therapy matter?, European Journal of Orthodontics. 2008, 30: 274-282.

 

Researcher : Anthonappa RP

List of Research Outputs

 

Anthonappa R.P., Yiu C.K.Y. and King N.M., A novel combination of dens evaginatus and dens invaginatus in a single tooth - review of the literature and a case report., J Clin Paediatr Dent. 2008, 32(3): 239-242.

 

Anthonappa R.P., Omer R.S.M. and King N.M., Characteristics of 283 supernumerary teeth in southern Chinese children, Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008, 105: e48-e54.

 

Researcher : Bendeus SAM

Project Title:

Correlation of the population size of mesenchymal cells and condylar growth

Investigator(s):

Bendeus SAM, Hagg EUO, Rabie ABM

Department:

Dental Faculty

Source(s) of Funding:

Seed Funding for New Staff

Start Date:

11/2003

 

Abstract:

To develop a scale to assess the number of mesenchymal stem cells and to measure the size of the condyles in children with retrognathic mandible, thereby identify the good candidates for functional appliance therapy.

 

Project Title:

Virtual or stone models of the dentition for diagnosis and assessment of treatment need

Investigator(s):

Bendeus SAM, McGrath CPJ, Hagg EUO

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

10/2005

 

Abstract:

The purposes of this studu are: 1) to compare assessment of orthodontic treatment need on plaster study models and virtual models 2) to compare assessment of space conditions of plaster models and virtual models

 

Project Title:

Antimicrobial Activity of Traditional Chinese Medicine (TCM) Against Candida Species

Investigator(s):

Bendeus SAM, Wong RWK, Samaranayake LP

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

01/2007

 

Abstract:

Introduction:Candida has arisen as a major human pathogen with the HIV/AIDS epidemic and the high prevalence of compromised populations due to increased transplantation and chemotherapeutic drug use (Ellepola and Samaranayake, 2000). Candidiasis has also emerged with high mortality rates, reported to be nearly 55% among compromised populations such as HIV/AIDS patients. Resurgence of candidiasis among this population has created a clinical dilemma due to emergence of non-albicans species such as C.glabrata, C.krusei and C.tropicalis as potential human pathogens. Further, the emergence of drug-resistant Candida in general and azoles in particular also contribute to drug failure in patients with oral candidiasis (White, Marr and Bowden, 1998). Thus, continuing efforts to develop new, more effective and safe antifungals against this ubiquitous pathogen are needed. "Traditional Medicines" in many parts of the world are essentially treatment modalities largely dependent on the properties of "medicinal plants". Although greater details of compounds isolated from these "traditional medicinal plants" are sparse in current literature, studies have shown that they have therapeutic properties of much interest. Moreover extracts of traditional medicinal plants have not only shown to be potentially therapeutic, but considerably less toxic (Masoko, Picard and Eloff, 2005). These properties make herbs, which are used in Traditional Chinese Medicine (TCM), good candidates as novel drugs. Hence, in this study, we attempt to evaluate eight TCM herbs for their anti-candidial activity. Thus, TCM herbs such as Cortex phellodendri Chinensis, Radix Scutellariae, Fructus Forsythiae, Rhizoma Coptidis, Radix bupleuri, Hebra Menthae, Flos Magnoliae, Flos Caryophylli will be assessed for their anti-fungal properties against six Candidia species namely C.ablicans, C.dubliensis, C.glabrata , C.krusei , C.tropicalis and C.parapsilosis. Objectives:1. To evaluate the anti-Candidial properties of TCM herbs namely Cortex phellodendri Chinensis, Radix Scutellariae, Fructus Forsythiae, Rhizoma Coptidis, Radix bupleuri, Hebra Menthae, Flos Magnoliae, Flos Caryophylli against six Candidia species 2. To determine the MIC values of potential anti-fungal agents3. To characterize the structural changes caused by TCM drugs on Candida cells.

 

List of Research Outputs

 

Chua H.D.P., Bendeus S.A.M. and Cheung L.K., Long term stability of cleft distraction osteogenesis versus orthognathic surgery, Second International Conference on Evidence-based Advanced Dentistry, Conjoint Congress 16-19 November 2007, Hong Kong. 2007, p. 34 (# 011).

 

Mok C.W., Zhou L., McGrath C.P.J., Hagg E.U.O. and Bendeus S.A.M., Digital images as an alternative to orthodontic casts in asessessing malocclusion and orthodontic treatment need , Acta Odontol. 2007, 65: 362-268.

 

Nelson B., Hagg E.U.O., Hansen K. and Bendeus S.A.M., A long-term follow-up study of Cass II malocclusion correction after treatment with Class II elastics or fixed functional appliances, American Journal of Orthodontics & Dentofacial Orthopedics. 2007, 132 No. 4: 499-503.

 

Zhou L., Mok C.W., Hagg E.U.O., McGrath C.P.J., Bendeus S.A.M. and Wu J.Y.C., Anteroposterior Dental Arch and Jaw-Base Relationships in a Population Sample, Angle Orthodontist. 2008, 78: 1023-1029.

 

Researcher : Bendeus SM

Project Title:

Correlation of the population size of mesenchymal cells and condylar growth

Investigator(s):

Bendeus SAM, Hagg EUO, Rabie ABM

Department:

Dental Faculty

Source(s) of Funding:

Seed Funding for New Staff

Start Date:

11/2003

 

Abstract:

To develop a scale to assess the number of mesenchymal stem cells and to measure the size of the condyles in children with retrognathic mandible, thereby identify the good candidates for functional appliance therapy.

 

Project Title:

Virtual or stone models of the dentition for diagnosis and assessment of treatment need

Investigator(s):

Bendeus SAM, McGrath CPJ, Hagg EUO

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

10/2005

 

Abstract:

The purposes of this studu are: 1) to compare assessment of orthodontic treatment need on plaster study models and virtual models 2) to compare assessment of space conditions of plaster models and virtual models

 

Project Title:

Antimicrobial Activity of Traditional Chinese Medicine (TCM) Against Candida Species

Investigator(s):

Bendeus SAM, Wong RWK, Samaranayake LP

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

01/2007

 

Abstract:

Introduction:Candida has arisen as a major human pathogen with the HIV/AIDS epidemic and the high prevalence of compromised populations due to increased transplantation and chemotherapeutic drug use (Ellepola and Samaranayake, 2000). Candidiasis has also emerged with high mortality rates, reported to be nearly 55% among compromised populations such as HIV/AIDS patients. Resurgence of candidiasis among this population has created a clinical dilemma due to emergence of non-albicans species such as C.glabrata, C.krusei and C.tropicalis as potential human pathogens. Further, the emergence of drug-resistant Candida in general and azoles in particular also contribute to drug failure in patients with oral candidiasis (White, Marr and Bowden, 1998). Thus, continuing efforts to develop new, more effective and safe antifungals against this ubiquitous pathogen are needed. "Traditional Medicines" in many parts of the world are essentially treatment modalities largely dependent on the properties of "medicinal plants". Although greater details of compounds isolated from these "traditional medicinal plants" are sparse in current literature, studies have shown that they have therapeutic properties of much interest. Moreover extracts of traditional medicinal plants have not only shown to be potentially therapeutic, but considerably less toxic (Masoko, Picard and Eloff, 2005). These properties make herbs, which are used in Traditional Chinese Medicine (TCM), good candidates as novel drugs. Hence, in this study, we attempt to evaluate eight TCM herbs for their anti-candidial activity. Thus, TCM herbs such as Cortex phellodendri Chinensis, Radix Scutellariae, Fructus Forsythiae, Rhizoma Coptidis, Radix bupleuri, Hebra Menthae, Flos Magnoliae, Flos Caryophylli will be assessed for their anti-fungal properties against six Candidia species namely C.ablicans, C.dubliensis, C.glabrata , C.krusei , C.tropicalis and C.parapsilosis. Objectives:1. To evaluate the anti-Candidial properties of TCM herbs namely Cortex phellodendri Chinensis, Radix Scutellariae, Fructus Forsythiae, Rhizoma Coptidis, Radix bupleuri, Hebra Menthae, Flos Magnoliae, Flos Caryophylli against six Candidia species 2. To determine the MIC values of potential anti-fungal agents3. To characterize the structural changes caused by TCM drugs on Candida cells.

 

 

Researcher : Botelho MG

Project Title:

The effectiveness of professional and home bleaching in the treatment of tetracycline stained teeth

Investigator(s):

Botelho MG, Chan AWK

Department:

Dental Faculty

Source(s) of Funding:

Low Budget High Impact Programme

Start Date:

11/2000

 

Abstract:

To compare the clinical efficacy or professional chairside bleaching with self-administered home bleaching for the aesthetic management of tetracycline stained teeth; to determine the cost effectiveness of the two bleaching procedures.

 

Project Title:

Antimicrobial effect of antibacterial conditioners on bacterial biofilms associated with dental caries

Investigator(s):

Botelho MG

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2003

 

Abstract:

To determine the inhibitory effects of dental antibacterials and novel dental antibacterial tooth conditioners against bacteria in biofilms.

 

Project Title:

Reduction of bacterial adhesion using a novel flurocarbon coating

Investigator(s):

Botelho MG

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

09/2006

 

Abstract:

The objectives of the proposed study it to test a novel fluorocarbon coating applied using a novel application technique developed at the Hong Kong University of Science and Technology. In preliminary studies this nano-sized coating shows a reduced ability of single species of oral bacteria to adhere to the test surface. The aim of the study is to quantify this effect using dental pathogenic bacteria using a flow cell. It is aimed to test this coating on dental material used in prosthetic appliances. These surfaces in the oral environment have been shown to readily form dental biofilm growth that may contribute to dental caries or periodontal disease. The aim of the study is to analyze to what extent this nanolayer coating may have on preventing early biofilm formation.

 

Project Title:

The effect of Silver Diammine Fluoride on demineralized dentine in vitro

Investigator(s):

Botelho MG

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

10/2006

 

Abstract:

The aims of this project are:1 To investigate the effects of SDF on artificially de-mineralized dentin in vitro so as to determine its anticaries effect on treating active caries. This will involve an analysis of the effects of concentration and time of SDF on arresting caries as well as the variable of depth of the lesion. This will be investigated using micro-hardness testing, energy dispersive X-ray microanalysis (EDAX) and electron microprobe analysis (EPMA) 2 To investigate the potential effects of other caries arresting agents similar to SDF (eg Ag NO3, AgF, TiF6, SiF6, ZrF6, SnF6, GeF6, Sr F2, NaF, KI…) but that do not have the deleterious effects of blackening associated with Ag ions. 3 To investigate the effect of SDF on treated deminerlized dentine that is subjected to demineralization cycles and determine its resistance to acid attack.While various forms of fluoride have been shown to be effective in preventing dental caries, a relatively new form, Silver Diammine Fluoride (SDF) has shown potential in arresting existing enamel and dentine caries. The advantage of this agent is that it is clinically easy to apply, can be administrated by oral health care personal with minimal training and is cost effective. However, its main disadvantage is that the silver oxidizes and turns the tooth black. This would make it unacceptable by most adult patients in the general population if aesthetically visible

 

List of Research Outputs

 

Bridges S.M., Dyson J.E., Botelho M.G., Corbet E.F. and Wong J.W., Online Resourcing for Problem-based Curricula: The HKU Faculty of Dentistry Approach, Workshop, Transforming learning through technology @HKU, Centre for Information Technology in Education (CITE) Symposium, The University of Hong Kong.. Hong Kong, 2008.

 

Pow E.H.N., Botelho M.G., Chow T.W., Dias A.P.L.H., Dyson J.E., Leung K.C.M. and McMillan A.S., Student's manual to the BDS V Prosthodontic Clinical Skills and Technology Course in Oral Rehabilitation 2007-2008. Hong Kong, 2007, 1-76.

 

Pow E.H.N., Botelho M.G., Chow T.W., Dias A.P.L.H., Dyson J.E., Leung K.C.M. and McMillan A.S., Teacher's manual to the BDS V Prosthodontic Clinical Skills and Technology Course in Oral Rehabilitation 2007-2008. Hong Kong, 2007, 1-89.

 

Researcher : Bridges SM

List of Research Outputs

 

Bridges S.M. and Poyatos Matas C., International Award for Excellence, In: COPE, Bill and KALANTZIS, Mary, International Journal of Diversity in Organisations, Communities and Nations. Common Ground, 2007.

 

Bridges S.M., Lau H.Y.K., Martyn E.R. and Pomfret D.M., Issues and dilemmas: The role of ICT@HKU. Plenary Panel, Transforming learning through technology @HKU, Centre for Information Technology in Education (CITE) Symposium, The University of Hong Kong.. Hong Kong, 2008.

 

Bridges S.M., Learner perceptions of a professional development immersion course, In: Anne Burns Helen de Silva-Joyce, Prospect . Macquarie University, Australia, NCELTR, 2007, 22 (2): 39-60.

 

Bridges S.M. and Poyatos Matas C., Narrating multicultural research, Plenary, In: Mary Kalantzis Paul James, Eighth International Conference on Diversity in Organisations, Communities and Nations, Montreal, Canada. Montreal, Canada, 2008.

 

Bridges S.M., Dyson J.E., Botelho M.G., Corbet E.F. and Wong J.W., Online Resourcing for Problem-based Curricula: The HKU Faculty of Dentistry Approach, Workshop, Transforming learning through technology @HKU, Centre for Information Technology in Education (CITE) Symposium, The University of Hong Kong.. Hong Kong, 2008.

 

Bridges S.M. and Bartlett B., Prospect or promise – Internationalisation in Australia, In: Christina Gitsaki , Language and Languages: Global and Local Tensions. Newcastle, UK, Cambridge Scholars Publications, 2007, 15-39.

 

Bridges S.M., Recipient's Speech - Award Presentation Ceremony, Seventh International Conference on Diversity in Organisations, Communities and Nations, Amsterdam, Holland. Amsterdam, Holland, 2007.

 

Bridges S.M., Dyson J.E. and Corbet E.F., Supporting Self-directed Learning in PBL though Online Concept Mapping. , Inaugural HKU-Wuhan University (WHU) Conjoint Scientific Meeting. 2008.

 

Bridges S.M., Dyson J.E. and Corbet E.F., Tools for Knowledge Co-construction – Online Concept Mapping to Support Self-directed Learning , 5th International PBL Conference, Newport, Rhode Island, USA, April 20 – 24 . 2008.

 

Bridges S.M., McGrath C.P.J. and Yiu C.K.Y., When official policies meet site-based realities: Diversity and clinical dental education in Hong Kong, Eighth International Conference on Diversity in Organisations, Communities and Nations. 2008.

 

Bridges S.M., McGrath C.P.J. and Yiu C.K.Y., Working the ‘place’ of languages in clinical dental education, 9th International Conference of the Association for Language Awareness. 2008.

 

Dyson J.E., Yiu C.K.Y., Samaranayake L.P., Bridges S.M., Lane T., Chan J.P.S., Cheng S.W. and Leung R.T.C., Problem-based learning in dentistry. Hong Kong, Faculty of Dentistry, The University of Hong Kong, 2008.

 

Wyatt-Smith C.M. and Bridges S.M., Evaluation Study, Literacy and Numeracy in the Middle Years of Schooling- Queensland Project Report: meeting in the middle - assessment, pedagogy, learning and educational disadvantage.. ACT, Commonwealth of Australia, 2007, 82-181.

 

Researcher : Chai JYC

List of Research Outputs

 

Chai J.Y.C., Chu F.C.S., Chow T.W. and Liang B.M.H., Chemical solubility and flexural strength of zirconia-based ceramics., International Journal of Prosthodontics . 2007, 20: 587-595.

 

Chu F.C.S., Chow T.W. and Chai J.Y.C., Contrast ratios and masking ability of three types of ceramic veneers, Journal of Prosthetic Dentistry. 2007, 98(5): 359-364.

 

Researcher : Chai L

List of Research Outputs

 

Chai L., Leung W.K., Zee K.Y. and Song Y., Association between FCGR3A polymorphisms and periodontitis in Hong Kong Chinese, Journal of Dental Research. 2007, 86 (Spec Iss B): IP-131.

 

Researcher : Chan AWK

Project Title:

A study to investigate the attitude and effect of magnification on the clinical performance by dental undergraduates in the University of Hong Kong

Investigator(s):

Chan AWK, Cheung GSP

Department:

Dental Faculty

Source(s) of Funding:

Low Budget High Impact Programme

Start Date:

11/2000

 

Abstract:

To evaluate dental students' attitudes towards the use of magnification in dentistry; to investigate the effect of magnification on the quality of typical restorative procedures undertaken by dental students; to investigate the influence of the use of magnification on decision-making behaviour in restorative treatment planning.

 

List of Research Outputs

 

Chan A.W.K. and Law N.C.M., Autoclave performance in private dental practices in Hong Kong, Hong Kong Dental Journal. 2007, 4: 102-112.

 

Chan A.W.K., 牙隱裂的診斷和治療, Dental Equipment and Materials. 2007, 3: 35-37.

 

Ko C.H.W., Cheung G.S.P. and Chan A.W.K., A review of a resin-based root canal filling material, Hong Kong Dental Journal. 2008, 5: 38-44.

 

Researcher : Chan JPS

List of Research Outputs

 

Dyson J.E., Yiu C.K.Y., Samaranayake L.P., Bridges S.M., Lane T., Chan J.P.S., Cheng S.W. and Leung R.T.C., Problem-based learning in dentistry. Hong Kong, Faculty of Dentistry, The University of Hong Kong, 2008.

 

Researcher : Chan KHC

List of Research Outputs

 

Pow E.H.N., Chan K.H.C., Luk W.K., Dias A.P.L.H. and McMillan A.S., Effect of laboratory procedures on casting magnetic keepers with gold alloy, Inaugural Conjoint Dental Scientific Meeting of the University of Hong Kong and Wuhan University. 2008.

 

Researcher : Chan PS

List of Research Outputs

 

Chan P.S., Ho J.C.S., Zee K.Y., Corbet E.F. and Leung W.K., The adjunctive use of Chinese medicine in non-surgical periodontal therapy, Journal of Dental Research. 2007, 86 (Spec Iss B): IP-141.

 

Researcher : Chau CM

List of Research Outputs

 

Chau C.M., Li T.K.L. and Mok W.H., 3D models showing relationship between horizontally impacted mandibular third molars and inferior dental canals using computed tomographic images, In: Balaji SM, Indian Journal of Maxillofacial & Oral Surgery. India, The Association of Oral and Maxillofacial Surgeons of, 2007, 6: 17-21.

 

Chau C.M. and Fung K.L., Dosimetry of implant imaging in three generations, Inaugural Conjoint Dental Scientific Meeting. 2008, 24.

 

Chau C.M., Oral Radiography, HKU Space, Dental Hygienists course. 2008.

 

Chau C.M., Oral Radiography, School of Dental Surgery Assistants. 2008.

 

Chau C.M., Radiation dose in dental implant imaging, 11th Congress of The European Academy of Dento-maxillo-facial Radiology. 2008.

 

Researcher : Chen L

Project Title:

C-fos expression and chromosomal changes in human ameloblastoma

Investigator(s):

Chen L, Cheung LK, Wong MP

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

 

Abstract:

To study the overall pattern of chromosomal alteration in multicystic and unicystic ameloblastoma by CGH and identify the important regions which may harbor critical genes involved in ameloblastoma pathogenesis.

 

 

Researcher : Cheng RHW

List of Research Outputs

 

Cheng R.H.W., Leung W.K. and Corbet E.F., Non-surgical periodontal therapy with adjunctive chlorhexidine use in adults with Down syndrome: A prospective case series, Journal of Periodontology (1970 : Online). 2008, 79: 379-385.

 

Cheng R.H.W., Leung W.K., Corbet E.F. and King N.M., Oral health status of adults with Down syndrome in Hong Kong, Special Care in Dentistry. 2007, 27: 134-138.

 

Researcher : Cheng SW

List of Research Outputs

 

Dyson J.E., Yiu C.K.Y., Samaranayake L.P., Bridges S.M., Lane T., Chan J.P.S., Cheng S.W. and Leung R.T.C., Problem-based learning in dentistry. Hong Kong, Faculty of Dentistry, The University of Hong Kong, 2008.

 

Researcher : Cheung BPK

List of Research Outputs

 

Leung K.C.M., McMillan A.S., Cheung B.P.K. and Leung W.K., Sjögren's syndrome sufferers have increased oral yeast levels despite regular dental care, Oral Diseases. 2008, 14: 163-173.

 

Samaranayake Y.H., Samaranayake L.P., Cheung B.P.K., Parahitiyawa N.B., Yau J.Y.Y. and Yeung S.K.W., Synergistic Inhibition of Candida biofilms by Lysozyme and Common Antifungals , Inaugural Conjoint Dental Scientific Meeting. The University of Hong Kong and Wuhan University 2008.

 

Researcher : Cheung GSP

Project Title:

A diagnostic model for C-configuration in mandibular molars

Investigator(s):

Cheung GSP

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2002

 

Abstract:

To establish a diagnostic method according to the relationship between the radiographic features and the anatomy of the C-shaped canal system in the mandibular second molars by using the micro-computerized tomography (MicroCT); to evaluate the accuracy of such a diagnostic method in vivo.

 

Project Title:

Fracture of endodontic instruments

Investigator(s):

Cheung GSP, Darvell BW

Department:

Dental Faculty

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

04/2007

 

Abstract:

The use of nickel-titanium (NiTi) instruments has been shown to produce a better result in root canal preparation than conventional stainless-steel instruments as part of endodontic treatment (dental treatment, that is, for the shaping of the root canal of a tooth in readiness for filling and sealing). In the process, the instrument is subject to both torsional and bending fatigue which results in breakage at a frequency of concern to both dentists and patients because of the difficulties of retrieval of the remaining fragment. Such failures are poorly understood.Objective:The purpose of the proposed investigation is to identify the key factors relating to the initiation of failure of nickel-titanium (NiTi) root canal instruments in clinical use.Key issues and long-term impact:a) Breakage of NiTi instruments occurs during root canal treatment at a significant frequency.b) There is no warning of such fracture but little is known about the underlying conditions and mechanism.c) Understanding the mechanism of failure and improving the material properties should lead to a reduction or elimination of such procedural errors in clinical practice.Problems to be addressed:(i) Identifying the mode and mechanism of fracture of NiTi instruments in use;(ii) Correlation of such failures with laboratory-generated fractures;(iii) Identifying the site of crack initiation;(iv) Identifying factors that predispose the instrument to failure.

 

List of Research Outputs

 

Cheung G.S.P., "Is fatigue a real threat leading to NiTi instrument breakage?", World Endodontic Congress, International Federation of Endodontic Associations, Vancouver, Canada, August 2007.

 

Cheung G.S.P., (i) From NiTi alloy to rotary instruments; (ii) Problem solving in endodontics (workshop), The University of Hong Kong Faculty of Dentistry 25th Anniversary Symposium. 2007.

 

Cheung G.S.P., Cyclic fatigue of NiTi instruments, Asian Endodontic Forum 2008, Kota Kinabalu, Malaysia. 2008.

 

Cheung G.S.P., Shen Y. and Darvell B.W., Does electropolishing improve the low-cycle fatigue behavior of a nickel-titanium rotary instrument in hypochlorite?, Journal of Endodontics. 2007, 33: 1217-1221.

 

Cheung G.S.P., Shen Y. and Darvell B.W., Effect of environment on low-cycle fatigue of a nickel-titanium instrument, Journal of Endodontics. 2007, 33: 1433-1437.

 

Cheung G.S.P. and Darvell B.W., Fatigue testing of a NiTi rotary instrument. Part 1: strain-life relationship, International Endodontic Journal. 2007, 40: 612-618.

 

Cheung G.S.P. and Darvell B.W., Fatigue testing of a NiTi rotary instrument. Part 2: fractographic analysis, International Endodontic Journal. 2007, 40: 619-625.

 

Cheung G.S.P., Hong Kong Dental Journal. 2007.

 

Cheung G.S.P., International Endodontic Journal. 2008.

 

Cheung G.S.P. and Darvell B.W., Low-cycle fatigue of NiTi rotary instruments of various cross-sectional shapes, International Endodontic Journal. 2007, 40: 626-632.

 

Cheung G.S.P. and Darvell B.W., Low-cycle fatigue of rotary NiTi endodontic instruments in hypochlorite solution, Dental Materials. 2008, 24: 753-9.

 

Cheung G.S.P., Mechanism of cutting with NiTi instruments: property & characteristics, Invited lecture to the Eastman Dental Institute, London, UK . 2008.

 

Cheung G.S.P., Post-endodontic restorations, 第二十五章 根管治療後的修復, In: 邊專, 樊明文, Endodontology. 現代牙髓病學, 北京, 人民衛生出版社, 2008, 300-309.

 

Cheung G.S.P., Surgical Endodontics, 第十九章 根管外科, In: 邊專, 樊明文, Endodontology. 現代牙髓病學, 北京, 人民衛生出版社, 2008, 247-256.

 

Cheung G.S.P., Visiting Associate Professor of Guanghua College of Stomatology at Sun Yat-sen University (2007-2009), 2008.

 

Fan W., Fan B., Gutmann J.L. and Cheung G.S.P., Identification of C-shaped canal systems in mandibular second molars. Part I: Radiographic and anatomic features revealed by intraradicular contrast medium, Journal of Endodontics. 2007, 33: 806-810.

 

Huang D.M., Luo H.X., Cheung G.S.P., Zhang L., Tan H. and Zhou X.D., Study of the progressive changes in canal shape after using different instruments by hand in simulated S-shaped canals, Journal of Endodontics. 2007, 33: 986-989.

 

Kim H.C., Cheung G.S.P., Lee C.J., Kim B.M., Park J.K. and Kang S.I., Comparison of forces generated during root canal shaping and residual stresses of three nickel-titanium rotary files by using a three-dimensional finite-element analysis, Journal of Endodontics. 2008, 34: 743-747.

 

Ko C.H.W., Cheung G.S.P. and Chan A.W.K., A review of a resin-based root canal filling material, Hong Kong Dental Journal. 2008, 5: 38-44.

 

Shen Y., Bian Z., Fan M.W., Peng B. and Cheung G.S.P., Characteristics of wedged debris in microcracks of clinically used ProTaper rotary instruments, The Chinese Journal of Dental Research. 2007, 10: 49-53.

 

Xu Q., Ling J.Q., Cheung G.S.P. and Hu Y., A quantitative evaluation of sealing ability of four obturation techniques using a glucose leakage test, Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007, 104: e109-e113.

 

Researcher : Cheung LK

Project Title:

Cell cultured mucosal compound graft healing - an animal study

Investigator(s):

Cheung LK, Tipoe GL

Department:

Dental Faculty

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

07/1999

 

Abstract:

To establish an animal model for the studying of healing cell cultured compound graft in the oral environment; to study the histological healing process of cell cultured mucosal transplant on the palate; to analyse the phenotypic characteristic of the healed graft before and after healing.

 

Project Title:

Transport distraction in the treatment of temporomandibular joint ankylosis

Investigator(s):

Cheung LK, Shi X

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2003

 

Abstract:

To establish an animal model of temporomandibular joint ankylosis; to compare the healing between condylectomy and transport distraction of the posterior mandibular ramus in the treatment of temporomandibular joint ankylosis.

 

Project Title:

Biochemical modulation of distraction of osteogenesis in mandibular lengthening

Investigator(s):

Cheung LK, Zheng L

Department:

Dental Faculty

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

12/2003

 

Abstract:

To determine the effect of rhBMP-2 on bone regeneration in mandibular distraction osteogenesis under different distraction rates; to determine the effect of recombinant tissue inhibitor of matrix metalloproteinase-1 (TIMP-1) on the bone resorption in mandibular distraction osteogenesis; to study the expression of endogenous BMPs, vacular endothelial growth factor (VEGF), matrix metalloproteinases (MMPs) and TIMPs at different distraction time; to compare the expression of endogenous BMPs, VEGF, MMPs and TIMPs under the influence of continuous or intermittent distraction.

 

Project Title:

Injectable tissue-engineered bone for mandibular distraction osteogenesis in smokers

Investigator(s):

Cheung LK, Zheng L

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

12/2005

 

Abstract:

The objectives of the present study are:1. To establish a nicotine-induced compromised bone healing (NICBH) model of rabbit mandibular distraction osteogenesis.2. To compare the differentiation and proliferation of mesenchymal stem cells (MSCs) isolated from normal and "smoking" rabbits.3. To study the influence of platelet rich plasma (PRP) on MSCs isolated from normal and "smoking" rabbits.4. To compare the influence of PRP, MSCs/PRP, and MSCs/PRP/bone morphogenetic protein (BMP) on enhancing bone healing in mandibular distraction osteogenesis of "smoking" rabbits.It is well recognized that nicotine has a deleterious effect on the human health in many aspects, one of them is that it can impact adversely on the tissue healing process after trauma and surgery. Thus the patients, who use tobacco products commonly as smoking, will be at a greater risk from bone reconstruction surgery. This study attempts to establish a reliable and repeatable NICBH model in rabbit undergoing mandibular distraction, which simulates the in vivo biological situation of light and heavy smokers having the same surgery.The individual MSCs, PRP and BMP have been identified to be capable of enhancing bone formation in mandibular reconstruction, it is reasonable to assume that they may speed up bone healing in the NICBH model. This study attempt to explore the potential of using PRP, MSCs and recombinant human BMP-2 (rhBMP-2) togather to enhance bone regeneration, and find a effective method to meet the clinical challenge of smokers who need bone reconstructive surgery by distraction osteogenesis.

 

Project Title:

Modulation of distraction osteogenesis in the irradiated mandible

Investigator(s):

Cheung LK, Zheng L, Chua DTT

Department:

Dental Faculty

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

01/2007

 

Abstract:

Purpose: To use an animal model to examine the role of genetically modified mesenchymal stem cells (MSCs) expressing bone morphogenetic protein-2 in improving a clinical tissue-engineering method (distraction osteogenesis) for jawbone reconstruction in irradiated mandible. Key issues and problems:1) High-dose irradiation used in the treatment of oral cancer compromises the biological environment of bone significantly, and results in decreased blood flow and progressive fibrosis. Mandibular bone is especially prone to irradiation damage because of its limited vascular supply and compact bony structure. 2) Conventional bone reconstructive surgery uses bone grafting, itself associated with wound complications at the donor graft site, but distraction osteogenesis regenerates bone without a graft by the gradual separation of the divided bone segments using a mechanical device. This method could be further improved for irradiated bone with stem cell technology.3) Distraction osteogenesis provides a promising tool to reconstruct the continuity defects of previously irradiated mandibles, but the compromised wound healing ability following radiotherapy, such as decreased vascularity and cellularity, hinders its application and remains the major concerns of the surgeons. 4) Implantation of pluripotent MSCs enhances bone healing and regeneration in wound-healing models. It is unknown whether transplanted MSCs retain their proliferation and differentiation abilities and reverse the compromised environment.5) Addition of growth factors may help MSCs in bone healing:i) Platelet-rich plasma (PRP) contains many growth factors in a biologically determined ratio and enhances the revascularization of wounds following trauma or surgery. However, its influence on distraction osteogenesis in an irradiation-compromised environment is unknown.ii) Bone morphogenetic protein-2 (BMP-2) is one of the most important protein that aid bone formation and healing. It is reasonable to expect but has not been studied that genetically modified MSCs expressing BMP-2 to compensate for low vascularity and cellularity caused by irradiation.Main study hypothesis: Genetically modified MSCs expressing BMP-2 in combination with PRP can reverse decreased vascularity and cellularity, thereby enhancing bone healing during jaw distraction osteogenesis in rabbits with irradiation compromised healing ability.Study objectives:1) To study the influence of radiation on a rabbit model of mandibular distraction osteogenesis.2) To explore the role of genetically modified MSCs in combination with PRP, in bone healing during jaw distraction osteogenesis in irradiation-compromised rabbits.

 

List of Research Outputs

 

Cheung L.K., 1) History, development and choices of distractors (chairman & keynote lecture) 2) Stereomodels in planning for distraction (chairman & keynote lecture) 3) Maxillary distraction (chairman & keynote lecture) 4) Intra-oral versus extra-oral distraction (chairman & keynote lecture) 5) Mandibular distraction (chairman & keynote lecture) 6) Alveolar distraction (chairman & keynote lecture) 7) Craniofacial distraction (chairman & keynote lecture), Synthes Distraction Course, Hong Kong, June 2008. 2008.

 

Cheung L.K., 1) AO implants and instrumentation (invited lecture) 2) Mandibular reconstruction with free bone grafts: indication, techniques and fixation (invited lecture) 3) Treatment of symphyseal and para-symphyseal fractures (invited lecture) 4) Maxillary osteotomies: techniques including DO (invited lecture), AO CMF Principles Course Programme, Bangalore, India. 2007.

 

Cheung L.K., 1) Distraction osteogenesis for maxillofacial deformities - a clinical tissue engineering method (invited lecture) 2) Orthognathic surgery for craniofacial syndromes (invited lecture), AO CMF advanced seminar, Cebu, Philippines, June. 2008.

 

Cheung L.K., 1) Distraction vs orthognathic surgery in clefts (invited lecture) 2) Resorbable vs titanium fixation (invited lecture) 3) Management of hemifacial microsomia (invited lecture) 4) Functional maxillofacial reconstruction with dental implants (invited lecture) 5) Cleft and Cranio-Maxillofacial anomalies (invited lecture), Society of OMS (NSW), Sydney and Cleft Children's Hospital, Melbourne, Australia. 2007.

 

Cheung L.K., 1) Stereomodel planning in CMF reconstruction (chairman & keynote lecture) 2) Distraction osteogenesis following free flap transfer (chairman & keynote lecture) 3) Implant rehabilitation after free flap transfer (chairman & keynote lecture), AO course on microvascular flaps for jaw reconstruction, Hong Kong , May. 2008.

 

Cheung L.K., Advances in dental implantology, The Hong Kong Medical Diary. 2007, 12: p 16-17.

 

Cheung L.K., Associate Editor (since April 1999), International Journal of Oral and Maxillofacial Surgery. 2007.

 

Cheung L.K., Associate Editor-in-Chief, Chinese Journal of Oral Implantology. 2007.

 

Cheung L.K., Changes in the faces and smiles of patients with dentofacial deformities (invited lecture), 2nd International Conference on Evidence-based Advanced Dentistry, Hong Kong. 2007.

 

Cheung L.K. and Chua H.D.P., Cleft maxillary distraction with internal distractor: clinical morbidities and surgical relapse, Inaugural Conjoint Dental Scientific Meeting, The University of Hong Kong and Wuhan University. 10-11 May, 2008, China. 2008, p. 45.

 

Cheung L.K., Clinical application of distraction osteogenesis for the oral and maxillofacial region (invited lecture), Asian Association of Oral and Maxillofacial Surgeons, Bali, Indonesia 28-29 June 2008. 2008.

 

Cheung L.K., Distraction for the treatment of TMJ ankylosis, AO Advanced course on endoscopic fixation and distraction osteogenesis. 2007.

 

Cheung L.K., Distraction for the treatment of temporomandibular joint ankylosis, AO Advanced course on endoscopic fixation and distraction osteogenesis. 2007.

 

Cheung L.K., Distraction or orthognathic surgery - which is better for cleft lip and palate patients?, 19th Convocation of the Royal Australasian College of Dental Surgeons Conjoint with the College of Dental Surgeons of Hong Kong, 30 May - 2 June 2008, Hong Kong. 2008, p. 21.

 

Cheung L.K., Distraction osteogenesis for maxillofacial deformities: a clinical tissue engineering technique (Invited lecture), Conference on "Mastering New Techniques in Maxillofacial Surgery and Implant Dentistry", Hong Kong. 2007.

 

Cheung L.K., Distraction osteogenesis for maxillofacial deformities: a clinical tissue engineering technique, Mastering New Techniques in Maxillofacial Surgery & Implant Dentistry. 14-18 October 2007, Hong Kong. 2007, p. 21.

 

Cheung L.K., Distraction osteogenesis for the correction of cleft maxillary deformities (Keynote lecture), Hong Kong Association for Cleft Lip and Palate, Hong Kong. 2007.

 

Cheung L.K., Distraction osteogenesis in correction of maxillofacial deformities - Hong Kong experience (Invited lecture), Annual Meeting of the Israel Association of Oral and Maxillofacial Surgeons, Haifa, Israel. 2007.

 

Cheung L.K., Editor (2001-2007), Hong Kong Medical Journal, Hong Kong. 2007.

 

Cheung L.K., Editor (since 1996), Stomatology Progress. 2007.

 

Cheung L.K., Editor (since 1997), Chinese Journal of Oral and Maxilloffacial Surgery. 2007.

 

Cheung L.K., Editor (since 2000), Asian Journal of Oral and Maxillofacial Surgery. 2007.

 

Cheung L.K., Editor (since 2001), Chinese Journal of Stomatological Information. 2007.

 

Cheung L.K., Editor (since 2002), West China Journal of Stomatology. 2007.

 

Cheung L.K., Editor (since 2002), Year-Book of Chinese Stomatology. 2007.

 

Cheung L.K., Honorary Editorial Advisor (since 2003), Hong Kong Dental Journal. 2007.

 

Cheung L.K., Implants for medically compromised patients (Invited Lecture), Diploma in Implant Dentistry, Royal College of Surgeons of England, London, U.K.. 2007.

 

Cheung L.K., Invited International Editorial Board Member (since 2002), China Journal of Oral and Maxillofacial Surgery. 2007.

 

Cheung L.K., Member of Editorial Board (since June 2008), International Journal of Dentistry. 2008.

 

Cheung L.K., Member of editorial board (since January 2008), Oral Disease. 2008.

 

Cheung L.K., Outstanding Oral Presentation Award at the Inaugural Conjoint Dental Scientific Meeting, The University of Hong Kong and Wuhan University, 10-11 May, 2008, Dongguan, China. . 2008.

 

Cheung L.K., Reviewer (since March 2006), Journal of Biomechanics. 2007.

 

Cheung L.K., Special Invited Editor (since 2003), Chinese Journal of Craniomaxillofacial Surgery. 2007.

 

Cheung L.K., Special Invited Editor (since 2003), Chinese Journal of Stomatological Research. 2007.

 

Cheung L.K., Yip I...H...S... and Chow R.L.K., Stability and morbidity of Le Fort I osteotomy with bioresorbable fixation: a randomized controlled trial, International Journal of Oral and Maxillofacial Surgery. 2008, 37: p. 232-241.

 

Cheung L.K., Chua H.D.P., Lo J. and Luk W.K., Vector guidance splint for internal maxillary distraction, Journal of Oral and Maxillofacial Surgery. 2007, 65 (9): p. 1852-1856.

 

Chow R.L.K. and Cheung L.K., The usefulness of stereomodels in maxillofacial surgical management, J Oral Maxillofac Surg. 2007, 65: p 2260-8.

 

Chua H.D.P., Bendeus S.A.M. and Cheung L.K., Long term stability of cleft distraction osteogenesis versus orthognathic surgery, Second International Conference on Evidence-based Advanced Dentistry, Conjoint Congress 16-19 November 2007, Hong Kong. 2007, p. 34 (# 011).

 

Hagg E.U.O. and Cheung L.K., Changes in the faces and smiles of patients with dentofacial deformities, Second International Conference on Evidence-based Advanced Dentistry, Conjoint Congress 16-19 November 2007, Hong Kong. 2007, p. 21-22.

 

Jayaratne Y.S.N., Lo J. and Cheung L.K., The use of 3-D photography for surgical planning in hemifacial microsomia, Second International Conference on Evidence-based Advanced Dentistry, Conjoint Congress 16-19 November 2007, Hong Kong. 2007, p. 60 (# 021).

 

Jayaratne Y.S.N., Lo J., Zwahlen R.A. and Cheung L.K., Virtual craniofacial model fabrication for surgical planning, Inaugural Conjoint Dental Scientific Meeting, The University of Hong Kong and Wuhan University. 10-11 May, 2008, China. 2008, p. 44.

 

Ke J., Zheng L. and Cheung L.K., Characterization of rabbit bone marrow stromal cells after cryopreservation, Inaugural Conjoint Dental Scientific Meeting, The University of Hong Kong and Wuhan University. 10-11 May, 2008, China. 2008, p. 36.

 

Leung M.Y.Y. and Cheung L.K., Outstanding Oral Abstract Presentation Award at the 19th Convocation of the Royal Australasian College of Dental Surgeons, Hong Kong, May 29 - June 2, 2008, Hong Kong. 2008.

 

Leung Y.Y. and Cheung L.K., Can coronectomy of wisdom teeth reduce the incidence of inferior dental nerve injury?, Inaugural Conjoint Dental Scientific Meeting, The University of Hong Kong and Wuhan University. 10-11 May, 2008, China. 2008, p. 40.

 

Leung Y.Y., Chow R.L.K. and Cheung L.K., Incidence of nerve injury and recovery after third molar surgery: a prospective study, Second International Conference on Evidence-based Advanced Dentistry, Conjoint Congress 16-19 November 2007, Hong Kong. 2007, p. 61 (# 022).

 

Lo J., Cheung L.K. and Jayaratne Y.S.N., 3-dimensional surgical planning of facial reconstruction in hemifacial microsomia , 89th Annual Meeting, American Oral & Maxillofacial Surgeons. 2007.

 

Lo J. and Cheung L.K., Distraction for the treatment of TMJ ankylosis, AO Course on Endoscopic Fixation and Advances in Distraction Osteogenesis . 2007.

 

Ma L., Zheng L. and Cheung L.K., Changes in blood supply and bone regeneration induced by nicotine during distraction osteogenesis, Bone. 2008, 42, S1: p. S60.

 

Ma L., Zheng L. and Cheung L.K., Influence of Nicotine on the expression of angiogenic factors in distraction osteogenesis, 1st International Bone and Dental Technology Symposium, November 2007, Bangkok, Thailand. 2007, p. 72.

 

Ma L., Zheng L. and Cheung L.K., The impact of Nicotine on blood perfusion and bone regeneration in distraction osteogenesis, Inaugural Conjoint Dental Scientific Meeting, The University of Hong Kong and Wuhan University. 10-11 May, 2008, China. 2008, p. 17.

 

Ma L., Zheng L. and Cheung L.K., The impact of nicotine on bone regeneration in distraction osteogenesis, Second International Conference on Evidence-based Advanced Dentistry, Conjoint Congress 16 - 19 November 2007, Hong Kong. 2007, p. 35 (# 013).

 

OW A. and Cheung L.K., Bilateral sagittal split osteotomies (BSSO) versus mandibular distraction osteogenesis: which is better?, Second International Conference on Evidence-based Advanced Dentistry, Conjoint Congress 16-19 November 2007, Hong Kong. 2007, p. 61 (#023).

 

Ow A. and Cheung L.K., Bilateral sagittal split osteotomies versus mandibular distraction osteogenesis: which is better?, Inaugural Conjoint Dental Scientific Meeting, The University of Hong Kong and Wuhan University. 10-11 May, 2008, China. 2008, p. 42.

 

Ow A...T...C... and Cheung L.K., Meta-analysis of mandibular distraction osteogenesis: clinical applications and functional outcomes, Plastic and Reconstructive Surgery. 2008, 121 (3): p. 54e - 69e.

 

Ow A.T.C. and Cheung L.K., Outstanding Oral Presentation Award at the Second International Conference on Evidence-Based Advanced Dentistry, Hong Kong, 16-19 November 2007. 2007.

 

WEY M.C., TAN M.N., LIM Y.C., Cheung L.K. and Lo J., Spectrum and surgical modalities of dentofacial deformities in Universiti Malaya and University of Hong Kong, Second International Conference on Evidence-based Advanced Dentistry, Conjoint Congress 16-19 November 2007, Hong Kong. 2007, p. 40 (P1).

 

Zheng L., Ma L. and Cheung L.K., Changes in blood perfusion and bone healing induced by nicotine during distraction osteogenesis. , Bone. 2008, 43: p. 355-361.

 

Zheng L. and Cheung L.K., Effect of recombinant human bone morphogenetic protein-2 on mandibular distraction osteogenesis, Hong Kong Dental Journal . 2007, 4 (No. 2): p. 94-100.

 

Zheng L., Cheung L.K., Ma L. and Wong M.C.M., High-rhythm automatic driver for bone traction: an experimental study in rabbits. , Int J Oral Maxillofac Surg . 2008, 37: p 736-740.

 

Zheng L., Ma L. and Cheung L.K., Influence of continuous traction on the gene expression of BMP-2 and TGF-β in distraction osteogenesis, 1st International Bone and Dental Technology Symposium, November 2007, Bangkok, Thailand. 2007, p. 63.

 

Zheng L., Ma L. and Cheung L.K., Influence of distraction frequency on angiogenesis in rabbit mandibular lengthening, Inaugural Conjoint Dental Scientific Meeting, The University of Hong Kong and Wuhan University. 10-11 May, 2008, China. 2008, p. 15.

 

Zheng L., Ma L. and Cheung L.K., Influence of frequency of mechanical traction on gene expression and angiogenesis in rabbit mandibular lengthening, Bone. 2008, 42, S1: p. S66 - S67.

 

Zheng L., Ma L. and Cheung L.K., Shall we rewrite the distraction protocol for continuous distraction osteogenesis?, Second International Conference on Evidence-based Advanced Dentistry, Conjoint Congress 16-19 November 2007, Hong Kong. 2007, p. 35 (# 012).

 

Researcher : Chiu WK

Project Title:

Pregabalin versus Carbamazepine for Patients with Neuropathic Orofacial Pain

Investigator(s):

Chiu WK, Cheung CW, Irwin MG

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2006

 

Abstract:

Neuropathic orofacial pain, particularly trigeminal neuralgia is a common and extremely unpleasant and debilitating condition which can severely affect sufferers quaity of life. Carbamazepine is an anticonvulsant blocking sodium channels and is currently the standard treatment for patients with neuropathic orofacial pain. However, its use is frequently limited by side effects such as dizziness, ataxia, marrow suppression, hypersensitivity reaction and liver dysfunction. These are potentially dangerous and close monitoring of complete blood picture, liver function and renal function are essential. Pregabalin (S-enantiomer of 3-aminomethyl-hexanoic acid) is a structural analogue of gamma-aminobutyric acid (GABA) but is functionally unrelated to it. It acts as a ligand at the alpha-2-delta binding site associated with voltage-gated calcium channels in the central nervous system. It is pharmacologically similar to gabapentin which is now well established in the treatment of neuropathic pain. However, it has a superior pharmacological profile: more predictable response with linear pharmacokinetic, higher oral bioavailability, fast onset, lack of drug interactions and better tolerability. Pregabalin has been shown to be effective in the treatment of diabetic neuropathy and post-herpetic neuralgia, and as well been used to treat epilepsy, neuropathic pain and anxiety. It is generally much well tolerated than carbamazepine. Objectives: 1. To evaluate and compare the efficacy of pregabalin and carbamazepine in patients with neuropathic orofacial pain 2. To evaluate and compare the side effects and tolerability of pregabalin and carbamazepine in patients with neuropathic orofacial pain 3. To evaluate the effects of pregabalin and carbamazepine on mood and sleep and quality of life of patients

 

List of Research Outputs

 

Cheung C.W., Ying C.L.A., Chiu W.K., Wong G.T.C. and Irwin M.G., A comparasion of intravenous sedation iwth Dexmedetomidine and Midazolam for Unilateral Third Molar Extraction under local anaesthesia, Anaesthesia. 2007, 62(11): 1132-1138.

 

Researcher : Chow RLK

List of Research Outputs

 

Cheung L.K., Yip I...H...S... and Chow R.L.K., Stability and morbidity of Le Fort I osteotomy with bioresorbable fixation: a randomized controlled trial, International Journal of Oral and Maxillofacial Surgery. 2008, 37: p. 232-241.

 

Chow R.L.K. and Cheung L.K., The usefulness of stereomodels in maxillofacial surgical management, J Oral Maxillofac Surg. 2007, 65: p 2260-8.

 

Leung Y.Y., Chow R.L.K. and Cheung L.K., Incidence of nerve injury and recovery after third molar surgery: a prospective study, Second International Conference on Evidence-based Advanced Dentistry, Conjoint Congress 16-19 November 2007, Hong Kong. 2007, p. 61 (# 022).

 

Researcher : Chow TW

List of Research Outputs

 

Chai J.Y.C., Chu F.C.S., Chow T.W. and Liang B.M.H., Chemical solubility and flexural strength of zirconia-based ceramics., International Journal of Prosthodontics . 2007, 20: 587-595.

 

Chow T.W., Performance of Small Diameter Implants, Second International Conference on Evidence-based Advanced Dentistry. 2007.

 

Chu F.C.S., Chow T.W. and Chai J.Y.C., Contrast ratios and masking ability of three types of ceramic veneers, Journal of Prosthetic Dentistry. 2007, 98(5): 359-364.

 

Chu F.C.S., Deng F., Siu S.C. and Chow T.W., The use of immediate implant placement for the replacement of a periodontally involved malaligned lateral incisor: A clinical report. , Journal of Prosthetic Dentistry . 2007, 98: 423-428.

 

Pow E.H.N., Botelho M.G., Chow T.W., Dias A.P.L.H., Dyson J.E., Leung K.C.M. and McMillan A.S., Student's manual to the BDS V Prosthodontic Clinical Skills and Technology Course in Oral Rehabilitation 2007-2008. Hong Kong, 2007, 1-76.

 

Pow E.H.N., Botelho M.G., Chow T.W., Dias A.P.L.H., Dyson J.E., Leung K.C.M. and McMillan A.S., Teacher's manual to the BDS V Prosthodontic Clinical Skills and Technology Course in Oral Rehabilitation 2007-2008. Hong Kong, 2007, 1-89.

 

Researcher : Chu CH

List of Research Outputs

 

Chu C.H. and Lo E.C.M., Dental caries prevention and treatment for preschool children in China, Chinese Journal of Dental Research. 2007, 10 (Suppl.): 54-60.

 

Chu C.H., Deputy Editor, Hong Kong Dental Journal. 2008.

 

Chu C.H. and Lo E.C.M., Micro-hardness of dentine after silver diamine fluoride application, International Journal of Pediatric Dentistry . 2007, 17 Suppl 1: OS084.

 

Chu C.H. and Lo E.C.M., Micro-hardness of dentine in primary teeth after topical fluoride applications, Journal of Dentistry. 2008, 36: 387-391.

 

Chu C.H. and Lo E.C.M., Oral health of school age children in Kampong Thum Cambodia, Journal of Dental Research. 2007, 86 (Spec Iss B): IO-70.

 

Chu C.H., Wong A.W.Y., Lo E.C.M. and Courtel F., Oral health status and behaviours of children in rural districts of Cambodia, International Dental Journal. 2008, 58: 15-22.

 

Chu C.H., Cheng H.F., Chiu H.C., Chiu L.P.Y., Choi T.Y., Lai I.A., Lee Y.M., Lo V.Y.M., Wu W.S. and Yeung M.K., Oral health status and oral features of Chinese people with Systemic Sclerosis (Scleroderma) in Hong Kong, Community Health Project Report Series. Faculty of Dentistry, The University of Hong Kong, 2008, 154: 1-53.

 

Chu C.H. and Lo E.C.M., Outstanding poster presentation in the Inaugural Conjoint Dental Scientific Meeting 2008 The University of Hong Kong and Wuhan University , Faculty of Dentistry, The University of Hong Kong and School of Stomatology, Wuhan University . 2008.

 

Chu C.H., Uses of Fluoride Varnish in Dental Practice, 19th Convocation of the Royal Australasian College of Dental Surgeons conjoint with The College of Dental Surgeons of Hong Kong. 2008.

 

Li T.F., Ng S.S.W., Yip W.C. and Chu C.H., Outreach dental service for people with cerebral palsy, Journal of Dental Research . 2007, 86 (Spec Iss B): IO-074.

 

Tsang A.Y.C., Ho L.I. and Chu C.H., Occlusion and orthodontic treatment need of young Chinese adults, Journal of Dental Research . 2007, 86 (Spec Iss B): IP-055.

 

Wong A.H.H., Lo E.C.M., Chu C.H. and Lin H.C., Two minimally invasive treatments for decayed primary molars - 24-month results, Journal of Dental Research. 2007, 86 (Spec Iss B): IP-013.

 

Wong A.H.H., Lo E.C.M., Chu C.H. and Lin H.C., Two minimally invasive treatments for decayed primary molars 18 month results, International Journal of Pediatric Dentistry. 2007, 17 Suppl 1: PO119.

 

You D.S.H., Chu C.H. and Lo E.C.M., Best presentation in the subject area "Cariology research" in the 21st Annual Scientific Meeting, Southeast Asian Division of International Association for Dental Research . 2007.

 

You D.S.H., Chu C.H. and Lo E.C.M., Precision of clinical diagnosis of fissure caries by different methods, Journal of Dental Research. 2007, 86 (Spec Iss B): IP-027.

 

Zhang C., Ip Y.S., Yeung A.S.H. and Chu C.H., Oral health status of Chinese adolescents with cerebral palsy, Journal of Dental Research . 2007, , 86 (Spec Iss B): IP-057.

 

Researcher : Chu FCS

Project Title:

A microbiological study of bone collected during immediate dental implant surgery

Investigator(s):

Chu FCS, Tsang PCS, Chow TW

Department:

Dental Faculty

Source(s) of Funding:

Low Budget High Impact Programme

Start Date:

11/2001

 

Abstract:

To compare the microbial contamination of bone collected from surgical sites with at least healing period of four weeks, and from fresh extraction sockets prepared for dental implants; to determine if bone grafts have to be collected from areas other than fresh extraction sockets; to identify if particular pre-extraction conditions.

 

List of Research Outputs

 

Chai J.Y.C., Chu F.C.S., Chow T.W. and Liang B.M.H., Chemical solubility and flexural strength of zirconia-based ceramics., International Journal of Prosthodontics . 2007, 20: 587-595.

 

Chu F.C.S., Chow T.W. and Chai J.Y.C., Contrast ratios and masking ability of three types of ceramic veneers, Journal of Prosthetic Dentistry. 2007, 98(5): 359-364.

 

Chu F.C.S., Journal of Endodontics, Member, Scientific Advisory Committee . 2007.

 

Chu F.C.S., Longevity of Fixed Prostheses , Second International Conference on Evidence-based Advanced Dentistry . 2007.

 

Chu F.C.S., Ten Outstanding Young Persons Award, Junior Chamber International Hong Kong, 2007. 2007.

 

Chu F.C.S., Deng F., Siu S.C. and Chow T.W., The use of immediate implant placement for the replacement of a periodontally involved malaligned lateral incisor: A clinical report. , Journal of Prosthetic Dentistry . 2007, 98: 423-428.

 

Leung W.K., Siu S.C., Chu F.C.S., Wong K.W., Jin L.J., Sham A.S.K., Tsang P.C.S. and Samaranayake L.P., Oral health status of low-income, middle-aged to elderly Hong Kong Chinese with type 2 diabetes mellitus , Oral Health & Preventive Dentistry. 2008, 6: 105-118.

 

Tsang P.C.S., Chu F.C.S., Leung W.K., Jin L.J., Samaranayake L.P. and Siu S.C., Phospholipase, proteinase and haemolytic activities of Candida albicans isolated from oral cavities of patients with type 2 diabetes mellitus, Journal of Medical Microbiology. 2007, 56: 1393-1398.

 

Researcher : Chua HDP

List of Research Outputs

 

Cheung L.K. and Chua H.D.P., Cleft maxillary distraction with internal distractor: clinical morbidities and surgical relapse, Inaugural Conjoint Dental Scientific Meeting, The University of Hong Kong and Wuhan University. 10-11 May, 2008, China. 2008, p. 45.

 

Cheung L.K., Chua H.D.P., Lo J. and Luk W.K., Vector guidance splint for internal maxillary distraction, Journal of Oral and Maxillofacial Surgery. 2007, 65 (9): p. 1852-1856.

 

Chua H.D.P., Bendeus S.A.M. and Cheung L.K., Long term stability of cleft distraction osteogenesis versus orthognathic surgery, Second International Conference on Evidence-based Advanced Dentistry, Conjoint Congress 16-19 November 2007, Hong Kong. 2007, p. 34 (# 011).

 

Chua H.D.P., The psychological adjustment of cleft lip and palate patients undergoing distraction osteogenesis and conventional orthognathic surgery (The best oral presentation award), 89th Annual Meeting of the American Association of Oral & Maxillofacial Surgeons, Scientific Sessions and Exhibition in conjunction with the Japanese Society of Oral & Maxillofacial Surgeons and the Korean Association of Oral & Maxillofacial Surgeons, Hawaii. 2007.

 

Researcher : Chua HDP

List of Research Outputs

 

Cheung L.K. and Chua H.D.P., Cleft maxillary distraction with internal distractor: clinical morbidities and surgical relapse, Inaugural Conjoint Dental Scientific Meeting, The University of Hong Kong and Wuhan University. 10-11 May, 2008, China. 2008, p. 45.

 

Cheung L.K., Chua H.D.P., Lo J. and Luk W.K., Vector guidance splint for internal maxillary distraction, Journal of Oral and Maxillofacial Surgery. 2007, 65 (9): p. 1852-1856.

 

Chua H.D.P., Bendeus S.A.M. and Cheung L.K., Long term stability of cleft distraction osteogenesis versus orthognathic surgery, Second International Conference on Evidence-based Advanced Dentistry, Conjoint Congress 16-19 November 2007, Hong Kong. 2007, p. 34 (# 011).

 

Chua H.D.P., The psychological adjustment of cleft lip and palate patients undergoing distraction osteogenesis and conventional orthognathic surgery (The best oral presentation award), 89th Annual Meeting of the American Association of Oral & Maxillofacial Surgeons, Scientific Sessions and Exhibition in conjunction with the Japanese Society of Oral & Maxillofacial Surgeons and the Korean Association of Oral & Maxillofacial Surgeons, Hawaii. 2007.

 

Researcher : Corbet EF

List of Research Outputs

 

Bridges S.M., Dyson J.E., Botelho M.G., Corbet E.F. and Wong J.W., Online Resourcing for Problem-based Curricula: The HKU Faculty of Dentistry Approach, Workshop, Transforming learning through technology @HKU, Centre for Information Technology in Education (CITE) Symposium, The University of Hong Kong.. Hong Kong, 2008.

 

Bridges S.M., Dyson J.E. and Corbet E.F., Supporting Self-directed Learning in PBL though Online Concept Mapping. , Inaugural HKU-Wuhan University (WHU) Conjoint Scientific Meeting. 2008.

 

Bridges S.M., Dyson J.E. and Corbet E.F., Tools for Knowledge Co-construction – Online Concept Mapping to Support Self-directed Learning , 5th International PBL Conference, Newport, Rhode Island, USA, April 20 – 24 . 2008.

 

Chan P.S., Ho J.C.S., Zee K.Y., Corbet E.F. and Leung W.K., The adjunctive use of Chinese medicine in non-surgical periodontal therapy, Journal of Dental Research. 2007, 86 (Spec Iss B): IP-141.

 

Cheng R.H.W., Leung W.K. and Corbet E.F., Non-surgical periodontal therapy with adjunctive chlorhexidine use in adults with Down syndrome: A prospective case series, Journal of Periodontology (1970 : Online). 2008, 79: 379-385.

 

Cheng R.H.W., Leung W.K., Corbet E.F. and King N.M., Oral health status of adults with Down syndrome in Hong Kong, Special Care in Dentistry. 2007, 27: 134-138.

 

Chong D.L.H., Zee K.Y. and Corbet E.F., Bone changes around osseointegrated dental implants in smokers and non-smokers, Journal of Dental Research. 2007, 86 (Spec Iss B): IP-118.

 

Corbet E.F., Editorial Board, Clinical Oral Implants Research. 2007.

 

Corbet E.F., Editorial Board, European Journal of Dental Education. 2007.

 

Corbet E.F., Editorial Board, Journal of Periodontal Research. 2007.

 

Corbet E.F., Honorary Editorial Advisor, Hong Kong Dental Journal. 2007.

 

Corbet E.F., Invited lecture, "Periodontal Esthetic Considerations", 1st Philippine Congress on Esthetic Dentistry, Manila, Philippines, January 21. 2008.

 

Corbet E.F., Invited lecture, “Full mouth debridement and probiotics in periodontal therapy”, “Dental implants in the periodontally susceptible”, 32nd Indian Society of Periodontology Conference, Davangere, India, December 28-29. 2007.

 

Corbet E.F., Invited lecture, “Integration and Connectedness in Dental Education through PBL”, New Frontiers in Education Technology, PBL and Objective Structured Clinical Examinations, International Symposium for Health Science Education, Showa University, Tokyo, July 31-2 August. 2007.

 

Corbet E.F., Invited lecture, “Supportive care for dental implant patients”, “Cervical dentine sensitivity and dental hygiene care” and “From biology to clinic: Periodontitis and peri-implantitis in the periodontally susceptible”, Australian Society of Periodontology Biennial International Conference, August 24 – 25. 2007.

 

Corbet E.F., Invited lecture, “The role of dental implants in the comprehensive care of periodontal patients”, 6th Vietnam Scientific Dental Congress, Ho Chi Minh City, Vietnam, November 28 – 31. 2007.

 

Corbet E.F., Reviewer, International Dental Journal. 2007.

 

Corbet E.F., Reviewer, Oral Health and Preventive Dentistry. 2007.

 

Corbet E.F., Reviewer, Quintessence International. 2007.

 

Corbet E.F., Akinwade J., Duggal R., Gebreegziabher G., Hirvikangas H., Hysi D., Katrova L., Karaharju-Suvanto T., McGrath C.P.J., Ono K., Radnai M., Schwarz E., Scott J., Sixou J.L., Soboleva U., Uoshima K., Yaneva-Ribagina K. and Fox C., Staff recruitment, development and global mobility, European Journal of Dental Education. 2008, 12 (Suppl. 1): 149-160.

 

Fung G.W.K., Zee K.Y. and Corbet E.F., Peri-implant bone level changes in patients with stable periodontal conditions, Journal of Dental Research. 2007, 86 (Spec Iss B): IP-071.

 

Fung G.W.K., Zee K.Y. and Corbet E.F., Peri-implant bone levels in patients treated for periodontitis, Inaugural University of Hong Kong - Wuhan University Conjoint Scientific Meeting, Donggguan, China, May 10. 2008.

 

Lai S.M.L., Zee K.Y. and Corbet E.F., Implant reconstructions in periodontally susceptible patients, Hong Kong Dental Journal. 2008, 5: 11-18.

 

Shum I.H.Y., Jin L.J., Leung P.C., Lau E., Kwok A., Corbet E.F. and Orwoll E.S., Association of periodontal disease with osteoporosis/osteopenia in Chinese Men, Journal of Dental Research. 2007, 86 (Spec Iss B): IP-126.

 

Tong K.S.K. and Corbet E.F., Periodontal referral in Hong Kong, Hong Kong Dental Journal. 2008, 5: 19-26.

 

Tse O.D., Jin L.J. and Corbet E.F., Treatment of periodontitis and CRP serum level in Chinese adults, Journal of Dental Research. 2007, 86 (Spec Iss B): IP-143.

 

Wong R.M.S., Ng S.K.S., Corbet E.F. and Leung W.K., Oral health-related quality of life changes upon non-surgical periodontal therapy, Journal of Dental Research. 2007, 86 (Spec Iss B): IP-139.

 

Zhu G., Li C., Cao Z., Corbet E.F. and Jin L.J., Toll-like receptors 2 and 4 gene polymorphisms in a Chinese population with periodontitis, Quintessence International. 2008, 39: 217-226.

 

Researcher : Dai J

List of Research Outputs

 

Dai J. and Rabie A.B.M., Gene therapy to enhance condylar growth using rAAV-VEGF, Angle Orthodontist. 2008, 78: 89-94.

 

Dai J. and Rabie A.B.M., VEGF: an essential mediator of both angiogenesis and endochondral ossification, Critical Reviews in Oral Biology & Medicine [incorporated in the Journal of Dental Research]. 2007, 86: 937-950.

 

Rabie A.B.M., Dai J. and Xu R., Recombinant AAV-mediated VEGF gene therapy induces mandibular condylar growth, Gene Therapy. 2007, 14: 972-980.

 

Researcher : Darvell BW

List of Research Outputs

 

Cheung G.S.P., Shen Y. and Darvell B.W., Does electropolishing improve the low-cycle fatigue behavior of a nickel-titanium rotary instrument in hypochlorite?, Journal of Endodontics. 2007, 33: 1217-1221.

 

Cheung G.S.P., Shen Y. and Darvell B.W., Effect of environment on low-cycle fatigue of a nickel-titanium instrument, Journal of Endodontics. 2007, 33: 1433-1437.

 

Cheung G.S.P. and Darvell B.W., Fatigue testing of a NiTi rotary instrument. Part 1: strain-life relationship, International Endodontic Journal. 2007, 40: 612-618.

 

Cheung G.S.P. and Darvell B.W., Fatigue testing of a NiTi rotary instrument. Part 2: fractographic analysis, International Endodontic Journal. 2007, 40: 619-625.

 

Cheung G.S.P. and Darvell B.W., Low-cycle fatigue of NiTi rotary instruments of various cross-sectional shapes, International Endodontic Journal. 2007, 40: 626-632.

 

Cheung G.S.P. and Darvell B.W., Low-cycle fatigue of rotary NiTi endodontic instruments in hypochlorite solution, Dental Materials. 2008, 24: 753-9.

 

Darvell B.W. and Dyson J.E., Chapter 1 : Characterizing The Performance of Dental Air Turbine Handpieces, In: Watson TF & Curtis RV, Dental Biomaterials: Imaging, Testing & Modelling. Cambridge, Woodhead, 2008.

 

Darvell B.W., Chapter 6 : Self-set problem-solving in laboratory practical work: ownership, In: RSY Berry, PPW Leung, Learning-Oriented Assessment: Useful Practice. HK, HKU Press, 2007.

 

Li Q.L., Chen Z.Q., Darvell B.W., Liu L.K., Jiang H.B., Zen Q., Peng Q. and Ou G.M., Chitosan-Phosphorylated Chitosan Polyelectrolyte Complex Hydrogel as an Osteoblast Carrier, J. Biomed. Mater. Res. B - Appl. Biomater. 2007, 82(2): 481-486.

 

Nomoto R., Mishima A., Kobayashi K., McCabe J.F., Darvell B.W., Watts D.C., Momoi Y. and Hirano S., Quantitative determination of radio-opacity: equivalence of digital and film x-ray systems, Dental Materials. Elsevier Ltd., 2008, 24: 141-147.

 

Pan H. and Darvell B.W., Solubility of calcium fluoride and fluorapatite by solid titration, Archives of Oral Biology. Elsevier, 2007, 52: 861-868.

 

Pan H. and Darvell B.W., Solubility of hydroxyapatite by solid titration at pH3-4, Archives of Oral Biology. Elsevier, 2007, 52: 618-624.

 

Wang Q., Chen Q., Zhu J., Huang C., Darvell B.W. and Chen Z., Effects of pore shape and porosity on the properties of porous LNKN ceramics as bone substitute, Materials Chemistry and Physics. Elsevier, 2008, 109: 488-491.

 

Wang Y. and Darvell B.W., Failure mode of dental restorative materials under Hertzian indentation, Dental Materials. Elsevier Ltd., 2007, 23: 1236-1244.

 

Zhang H. and Darvell B.W., Effect of amine additives on the morphology of hydroxyapatite, Key Engineering Materials. Switzerland, Trans Tech Publications, 2008, 361-363: 115-118.

 

Researcher : Deng F

List of Research Outputs

 

Chu F.C.S., Deng F., Siu S.C. and Chow T.W., The use of immediate implant placement for the replacement of a periodontally involved malaligned lateral incisor: A clinical report. , Journal of Prosthetic Dentistry . 2007, 98: 423-428.

 

Researcher : Dias APLH

List of Research Outputs

 

Luk W.K., Pow E.H.N. and Dias A.P.L.H., A Qualtiy Assessment of the Casting Process on Magnetic Keepers, Journal of Prosthodontics. 2007, 16: 249-254.

 

Pow E.H.N., Chan K.H.C., Luk W.K., Dias A.P.L.H. and McMillan A.S., Effect of laboratory procedures on casting magnetic keepers with gold alloy, Inaugural Conjoint Dental Scientific Meeting of the University of Hong Kong and Wuhan University. 2008.

 

Pow E.H.N., Botelho M.G., Chow T.W., Dias A.P.L.H., Dyson J.E., Leung K.C.M. and McMillan A.S., Student's manual to the BDS V Prosthodontic Clinical Skills and Technology Course in Oral Rehabilitation 2007-2008. Hong Kong, 2007, 1-76.

 

Pow E.H.N., Botelho M.G., Chow T.W., Dias A.P.L.H., Dyson J.E., Leung K.C.M. and McMillan A.S., Teacher's manual to the BDS V Prosthodontic Clinical Skills and Technology Course in Oral Rehabilitation 2007-2008. Hong Kong, 2007, 1-89.

 

Researcher : Dyson JE

List of Research Outputs

 

Bridges S.M., Dyson J.E., Botelho M.G., Corbet E.F. and Wong J.W., Online Resourcing for Problem-based Curricula: The HKU Faculty of Dentistry Approach, Workshop, Transforming learning through technology @HKU, Centre for Information Technology in Education (CITE) Symposium, The University of Hong Kong.. Hong Kong, 2008.

 

Bridges S.M., Dyson J.E. and Corbet E.F., Supporting Self-directed Learning in PBL though Online Concept Mapping. , Inaugural HKU-Wuhan University (WHU) Conjoint Scientific Meeting. 2008.

 

Bridges S.M., Dyson J.E. and Corbet E.F., Tools for Knowledge Co-construction – Online Concept Mapping to Support Self-directed Learning , 5th International PBL Conference, Newport, Rhode Island, USA, April 20 – 24 . 2008.

 

Darvell B.W. and Dyson J.E., Chapter 1 : Characterizing The Performance of Dental Air Turbine Handpieces, In: Watson TF & Curtis RV, Dental Biomaterials: Imaging, Testing & Modelling. Cambridge, Woodhead, 2008.

 

Dyson J.E., Air turbine handpieces -implications of recent research on their selection and use., Oral Health and Science Seminar. Faculty of Dentistry, The University of Hong Kong.. 2008.

 

Dyson J.E., Assessment in a PBL curriculum, U21 Health Sciences Annual Meeting. 2007.

 

Dyson J.E., Honorary Editorial Advisor, Hong Kong Dental Journal. Hong Kong Dental Association, 2007.

 

Dyson J.E., Integrating disciplines: Conceptualisation to actualisation. Keynote Lecture, Teaching Matters: Teaching Conference. University of Hobart. 2007.

 

Dyson J.E., PBL Facilitator Basic Training Workshops, Faculty of Dentistry, University of Hong Kong. 2007.

 

Dyson J.E., Yiu C.K.Y., Samaranayake L.P., Bridges S.M., Lane T., Chan J.P.S., Cheng S.W. and Leung R.T.C., Problem-based learning in dentistry. Hong Kong, Faculty of Dentistry, The University of Hong Kong, 2008.

 

Pow E.H.N., Botelho M.G., Chow T.W., Dias A.P.L.H., Dyson J.E., Leung K.C.M. and McMillan A.S., Student's manual to the BDS V Prosthodontic Clinical Skills and Technology Course in Oral Rehabilitation 2007-2008. Hong Kong, 2007, 1-76.

 

Pow E.H.N., Botelho M.G., Chow T.W., Dias A.P.L.H., Dyson J.E., Leung K.C.M. and McMillan A.S., Teacher's manual to the BDS V Prosthodontic Clinical Skills and Technology Course in Oral Rehabilitation 2007-2008. Hong Kong, 2007, 1-89.

 

Researcher : Fung GWK

List of Research Outputs

 

Fung G.W.K., Zee K.Y. and Corbet E.F., Peri-implant bone level changes in patients with stable periodontal conditions, Journal of Dental Research. 2007, 86 (Spec Iss B): IP-071.

 

Fung G.W.K., Zee K.Y. and Corbet E.F., Peri-implant bone levels in patients treated for periodontitis, Inaugural University of Hong Kong - Wuhan University Conjoint Scientific Meeting, Donggguan, China, May 10. 2008.

 

Researcher : Fung KC

List of Research Outputs

 

McGrath C.P.J., Chan S.Y., Chan K.T.H., Fu L.W., Fung K.C., Hon M.K., Lai C.L., Lam S.N., Wan P.C., Wong C.M. and Yung K.Y., Outreach dental services in the 'City of Sadness', Community Health Project Report Series. Faculty of Dentistry, The University of Hong Kong, 2008, 157: 1-49.

 

Researcher : Fung PL

List of Research Outputs

 

Wong M.C.M., Lui K.C., Chan M.H., Cheng G.W.K., Cheung A.W.T., Cheung G.J.K., Fung P.L., Fung S.L., Lam Y.H., Mui N.H.T., Wong K.L. and Wong K.Y., Oral health care for inmates of rehabilitation centres in Hong Kong, Community Health Project Report Series. Faculty of Dentistry, The University of Hong Kong, 2008, 152: 1-50.

 

Researcher : Hagg EUO

Project Title:

Temporo-mandibular joint adaptation to extended mandibular forward positioning in two phases separated by a rest period. An experimental study

Investigator(s):

Hagg EUO, Rabie ABM

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2002

 

Abstract:

To reveal the molecular control mechanism of temporo-mandibular joint adaptation in response to extended mandibular forward positioning in two phases separated by a rest period.

 

Project Title:

Biological responses of mandibular condyle to bite-jumping in adult rats

Investigator(s):

Hagg EUO, Rabie ABM, Xiong H

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2003

 

Abstract:

To explore the biological responses of mandibular condyle to bite-jumping in adult rats.

 

Project Title:

The effects of buguzhi on osteogenesis

Investigator(s):

Hagg EUO, Rabie ABM, Wong RWK

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

 

Abstract:

To investigate the effects of Buguzhi, a kind of traditional Chinese medicine, on osteogenesis.

 

Project Title:

A case-control study of treated and untreated severe incisor overjet on quality of life of adolescents and adults : a multi-centre cohort study

Investigator(s):

Hagg EUO, McGrath CPJ

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

10/2005

 

Abstract:

Objectives :1) to assess the impact of oral health on quality of life of adolescents and adults in China with severe incisor overjet;2 )to assess the impact of oral health on quality of life of adolescents and adults in China whose severe overjet have been treated;3) to determine differences in the impact of oral health on quality of life among adolescents and adults in China, between those treated and untreated. In addition, to identify factors (socio-demographic and clinical) associated the difference in oral health, related quality of life.

 

Project Title:

In vitro study of Traditional Chinese Medicine (TCM) extracts on common Biofilm forming organisms

Investigator(s):

Hagg EUO, Wong RWK, Samaranayake LP

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

01/2007

 

Abstract:

Plaque biofilms develop on all natural shedding and non-shedding surfaces of the oral cavity, as well as on foreign materials introduced into this milieu. The presence of biofilms can be attributed as the causative factor of many oral infections including caries periodontal disease and candidiasisInvisalign appliances are a newly developed form of plastic splints worn, in the mouth for orthodontic purposes for prolonged periods The appliance works on a similar principle to post-treatment tooth aligners, with the `teeth` in the appliance deliberately set up to a desired altered position, and pressure from the plastic of the appliance causing the desired tooth movement. Invisalign patients generally wear 24-30 sets of these clear, medical grade polycarbonate aligners during a course of treatment, full time (except for meals and oral hygiene) for periods of 2 weeks per alignerThe objectives of this study are to evaluate the effect of various TCM extracts on commonly found biofilm bacteria, growing on the Invisalign orthodontic appliance. The effect of the extracts will be determined based on the MIC as well as time fast effectiveness of the extracts against commonly found bacteria.

 

List of Research Outputs

 

Hagg E.U.O., Wong R.W.K., Samaranayake L.P., Kao R. and Yuen M., A Natural Edible Agent for Reduction of Oral Biofilm, IADR/GSK Innovation in Oral Care Awards. Awarded by IADR and GlaxoSmithKline Consumer Healthcare, 2 – 5 July, 2008 . 2008.

 

Hagg E.U.O., Wong R.W.K., Samaranayake L.P., Kao R. and Yuen M., A Natural Edible Agent for Reduction of Oral Biofilm, IADR/GSK Innovation in Oral Care Awards. External funding, US$ 75,000 unrestricted research grant. Awarded by IADR and GlaxoSmithKline Consumer Healthcare, 2 – 5 July, 2008. 2008.

 

Hagg E.U.O., Ng T.C.S. and Wong R.W.K., Anterior Bite: Interceptive Treatment, Dental Asia. 2008, September/October 2007: 39-45.

 

Hagg E.U.O. and Cheung L.K., Changes in the faces and smiles of patients with dentofacial deformities, Second International Conference on Evidence-based Advanced Dentistry, Conjoint Congress 16-19 November 2007, Hong Kong. 2007, p. 21-22.

 

Hagg E.U.O., McGrath C.P.J. and Zhang M., Quality of life and orthodontic treatment need related to occlusal indices, The Hong Kong Medical Diary. 2007, 12: 8-11.

 

Hagg E.U.O., Wong R.W.K. and Tng T.T.H., Severe transposition, ectopic eruption, and orthodontic alignment: A long-term appraisal, World Journal of Orthodontics. 2007, 8, Issue 3: 232-240.

 

Lee W., Low K...M..., Samaranayake L.P. and Hagg E.U.O., Genotypic variation of Candida albicans during orthodontic therapy, Frontiers in Bioscience. 2008, 13: 3814-3824.

 

Lee W., Wong R.W.K., Ikegami T. and Hagg E.U.O., Maxillary Second Molar Extractions in Orthodontic Treatment, World Journal Orthodontics 2008. 2008, 9: 52-61.

 

McGrath C.P.J., Pang H.H., Lo E.C.M., King N.M., Hagg E.U.O. and Samman N., Translation and evaluation of a Chinese version of the child oral health-related quality of life measure., Int J Paediatr Dent. 2008, 18: 267-274.

 

Mok C.W., Zhou L., McGrath C.P.J., Hagg E.U.O. and Bendeus S.A.M., Digital images as an alternative to orthodontic casts in asessessing malocclusion and orthodontic treatment need , Acta Odontol. 2007, 65: 362-268.

 

Nelson B., Hagg E.U.O., Hansen K. and Bendeus S.A.M., A long-term follow-up study of Cass II malocclusion correction after treatment with Class II elastics or fixed functional appliances, American Journal of Orthodontics & Dentofacial Orthopedics. 2007, 132 No. 4: 499-503.

 

Ng C.S.T., Wong R.W.K. and Hagg E.U.O., Orthodontic treatment of anterior open bite. , International Journal of Paediatric Dentistry . 2008, Vol. 18: 78-83.

 

Tang J.Y., Zeng Y.S., Chung P., Wong R.W.K. and Hagg E.U.O., Effects of Valeriana officinalis extract on rat depressive model., Journal of Chinese Clinical Medicine 2008,. 2008, 3, No. 7: 374-378.

 

Wiechmann D., Wong R.W.K. and Hagg E.U.O., Incognito – the Novel CAD/CAM Lingual Orthodontic Appliance. , Dental Asia . 2008, January/ February 2008: 19-25.

 

Wong R.W.K., Rabie A.B.M., Bendeus M. and Hagg E.U.O., The effects of Rhizoma Curculiginis and Rhizoma Drynariae extracts on bones , Chinese Medicine . 2007, 2: 1-13.

 

Wu C.C.L., Wong R.W.K. and Hagg E.U.O., A review of hypodontia: the possible etiologies and orthodontic, surgical and restorative treatment options – conventional and futuristic., Hong Kong Dental Journal . 2007, Vol. 4 No.2, December: 113-121.

 

Zhang M., McGrath C.P.J. and Hagg E.U.O., Changes in oral health-related quality of life during fixed orthodontic appliance therapy, American Journal of Orthodontics and Dentofacial Orthopedics. 2008, 133: 25-29.

 

Zhou L., Mok C.W., Hagg E.U.O., McGrath C.P.J., Bendeus S.A.M. and Wu J.Y.C., Anteroposterior Dental Arch and Jaw-Base Relationships in a Population Sample, Angle Orthodontist. 2008, 78: 1023-1029.

 

Researcher : Hiraishi N

List of Research Outputs

 

Chung C.W.M., Yiu C.K.Y., King N.M. and Hiraishi N., Effect of saliva contamination on bond strength of luting cements to dentine., Inaugural University of Hong Kong - Wuhan University Conjoint Scientific Meeting, Donggguan, China, May 10. 2008, Abstract P-21.

 

Dhanpal P.K., Yiu C.K.Y., King N.M., Tay F.R.C.M. and Hiraishi N., Effect of temperature on water sorption and solubility of dental adhesive resins, Second International Conference on Evidence-based Advanced Dentistry, Conjoint Congress 16-19 November, Hong Kong. 2007. P.68 Abstract P-26.

 

Hiraishi N., Yiu C.K.Y., King N.M., Tay F.R.C.M. and Pashley D.H., Chlorhexidine release and water sorption characterisitcs of chlorhexidine-incorporated hydrophobic/hydrophilic resins., Dent Materials. 2008, 24: 1391-9.

 

Hiraishi N., Yiu C.K.Y., King N.M., Tay F.R.C.M. and Pashley D.H., Chlorhexidine release and water sorption characteristics of chlorhexidine-incorporated dental adhesive resins, Second International Conference on Evidence-based Advanced Dentistry, Conjoint Congress 16-19 November, Hong Kong. 2007. P.71 P-30.

 

Hiraishi N., Yiu C.K.Y. and King N.M., Effect of acid etching time on bond strength of an etch-and-rinse adhesive to primary tooth dentine affected by amelogenesis imperfecta. , International Journal of Paediatric Dentistry. 2008, 18(3): 224-230.

 

Hiraishi N., Yau J.Y., Loushine R.J., Armstrong S.R., Weller R.N., King N.M., Pashley D.H. and Tay F.R.C.M., Susceptibility of a polycaprolactone-based root canal filling material to degradation: III. Turbdimetric evaluation of enzymatic hydrolysis., J Endod. 2007, 33(8): 952-956.

 

Hiraishi N., Breschi L., Prati C., Ferrari M., Tagami J. and King N.M., Technique sensitivity associated with air-drying of HEMA-free, single-bottle,one-step self-etch adhesives., Dent Mater. 2007, 23(4): 498-505.

 

Peerzada F., Yiu C.K.Y., King N.M. and Hiraishi N., Effect of surface preparation on bond strength of luting cement to dentine, Inaugural University of Hong Kong - Wuhan University Conjoint Scientific Meeting, Donggguan, China. May 10, 2008. P-22.

 

Yiu C.K.Y., Hiraishi N., King N.M. and Tay F.R., Effect of dentinal surface preparation on bond strength of self-etching adhesives, Journal of adhesive dentistry. 2008, 10: 173-182.

 

Yiu C.K.Y., Hiraishi N., King N.M. and Tay F.R.C.M., Effect of pulpal pressure on bond strength of luting cements to dentin, Second International Conference on Evidence-based Advanced Dentistry, Conjoint Congress 16-19 November, Hong Kong. 2007. P.38 O-17.

 

Researcher : Ho JCS

List of Research Outputs

 

Chan P.S., Ho J.C.S., Zee K.Y., Corbet E.F. and Leung W.K., The adjunctive use of Chinese medicine in non-surgical periodontal therapy, Journal of Dental Research. 2007, 86 (Spec Iss B): IP-141.

 

Researcher : Holmgren CJ

List of Research Outputs

 

Lo E.C.M., Holmgren C.J., Hu D. and van Palenstein Helderman W., Six-year follow up of atraumatic restorative treatment restorations placed in Chinese school children, Community Dentistry and Oral Epidemiology. 2007, 35: 387-392.

 

Researcher : Itthagarun A

Project Title:

New concepts for selective removal of carious dentition

Investigator(s):

Itthagarun A, King NM, Tay FRCM

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

 

Abstract:

To evaluate and compare the bonding efficacy of cavities prepared by 'SmartPrep' & 'CalrisolvTM on primary teeth, with those prepared by a conventional bur; to evaluate and compare the bonding efficacy of cavities prepared by 'CalrisolvTM, on primary teeth, with those prepared by a conventional bur; to evaluate and compare the bonding efficacy of cavities prepared, in primary teeth, by 'SmartPrep' with those prepared by CarisolvTM.

 

Project Title:

The effect of R.O.C.S (remineralizing oral care system) toothpaste on artificial caries like lesions: An in vitro pH cycling study.

Investigator(s):

Itthagarun A, King NM, Rana R

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

10/2005

 

Abstract:

Recent advances in the technique of processing microradiographs by computer-aided image analysis allow the mineral profiles of enamel lesions to be assessed with great accuracy (Strang et al., 1987; Heaven et al., 1990; Chow et al., 1992). It is now possible to measure small changes in these profiles following exposure of the lesions to demineralization and/or remineralization in laboratory models, as well as in the oral environment (Strang et al., 1986). Unfortunately, the comparison of experimental and control sections is hampered by the biological variation in the enamel itself, especially by inhomogeneous lesions, even when they are prepared under standardized conditions (Strang et al., 1986). Several research groups have developed a 'single section technique', mainly for the purpose of determining differences between pre- and post experimental profiles at exactly the same spot (Creanor et al., 1986; Mellberg et al., 1986; Wefel et al., 1987). Since thin sections can be repeatedly subjected to microradiographic assessment during or between experimental treatments, this technique offers the possibility of determining time-dependent changes in lesion profiles resulting from localized dissolution or deposition of enamel. It may thus help to resolve the mechanisms which underlie the formation of subsurface lesions and laminations (Driessens et al., 1986; Palamara et al., 1986; Sato and Yamamoto, 1986), and the effects of both caries-protective agents and inhibitors of remineralization.Ten Cate and Duijsters (1982) developed a so-called 'pH cycling model' involving tooth enamel and intra-oral-like conditions of de/remineralization solution, and pH ranges. This in vitro technique has been widely accepted because it can simulate in vivo situations more closely than traditional experimental studies. Since then, many researchers have adopted and modified such pH cycling methods to use in both enamel and root lesion experiments (Featherstone, 1983; Ten Cate et al., 1988; Heilman et al., 1991; Itthagarun et al., 1997). The version developed by Itthagarun et al., has been used extensively to evaluate remineralizing agents in toothpaste, chewing gums and lozenges (Itthagarun et al., 1999; 2000; 2004; 2005). Recently R.O.C.S toothpastes (Remineralizing oral care systems, DRC Ltd, Moscow, Russia) have been marketed for school children and adults. It has been claimed by the company that these toothpastes 'accelerate the formation of enamel' and 'primary caries focus is enriched with minerals'. The main active ingredients of R.O.C.S. for school-children are complex AMIFLUOR® (minerals) with fluorine and xylitol, while the R.O.C.S toothpaste intend for use by adults contains MINERALIN® and bromelaine, a source of calcium, phosphorus and magnesium. Currently, no published data are available in the English literature. Xylitol has been found to induce remineralization of demineralized enamel by facilitating calcium movement and accessibility (Miake et al, 2003). It also raises the pH of saliva and changes both the quantity and quality of saliva, thus aiding the remineralization process.Bromelaine has been found to provide an anti-inflammatory effect and has been used in medicine and in dentistry, following third molar extractions (Hotz et al, 1989) Consequently, the essence of the remineralizing concept of R.O.C.S. might be achieved by simultaneously supplying calcium, phosphate, and fluoride ions to the teeth in order to induce the formation of calcium fluoroapatite which remineralizes and strengthens the tooth (Torrado et al, 2004). However, as no evidence on the remineralization effects of R.OC.S toothpaste has been published in the English literature, it is appropriate to evaluate the remineralizing effects claimed and also to determine the mechanics involved. Objectives of the study:The aims of this in vitro pH cycling study is to use the single-section technique together with our modified pH cycling model to evaluate the effects of R.O.C.S schooldchildren and R.O.C.S adult toothpastes on the remineralization of enamel artificial caries-like lesions. Their remineralization efficacy will also be compared with that of a standard fluoride toothpastes intended for both children and adults.Key issues and problems to be addressed:Hypothesis to be testedo The new R.O.C.S. toothpastes for children will enhance remineralization of initial carious lesions in tooth enamel more effectively than non-fluoride child toothpaste o The new R.O.C.S. toothpastes for children will show similar 'healing' efficacy of the enamel initial cariuos lesions when compared to that of a standard fluoride toothpaste for children (500ppmF)o The new R.O.C.S. toothpastes for adults will enhance remineralization of initial carious lesion in tooth enamel more effectively than non-fluoride toothpasteo The new R.O.C.S. toothpastes for adults will show similar 'healing' efficacy of the enamel initial carious lesions when compared to that of the standard fluoride toothpaste for adults (1000ppmF)

 

List of Research Outputs

 

Itthagarun A., Thaveesangpanich P., King N.M., Tay F.R.C.M. and Wefel J.S., Effects of different amounts of a low fluoride toothpaste on primary enamel lesion progression: a preliminary study using in vitro pH-cycling system. , Eur Arch Paediatr Dent. 2007, 8(1): 69-73.

 

Researcher : Jayaratne YSN

List of Research Outputs

 

Jayaratne Y.S.N., Lo J. and Cheung L.K., The use of 3-D photography for surgical planning in hemifacial microsomia, Second International Conference on Evidence-based Advanced Dentistry, Conjoint Congress 16-19 November 2007, Hong Kong. 2007, p. 60 (# 021).

 

Jayaratne Y.S.N., Lo J., Zwahlen R.A. and Cheung L.K., Virtual craniofacial model fabrication for surgical planning, Inaugural Conjoint Dental Scientific Meeting, The University of Hong Kong and Wuhan University. 10-11 May, 2008, China. 2008, p. 44.

 

Lo J., Cheung L.K. and Jayaratne Y.S.N., 3-dimensional surgical planning of facial reconstruction in hemifacial microsomia , 89th Annual Meeting, American Oral & Maxillofacial Surgeons. 2007.

 

Researcher : Jayasinghe RD

List of Research Outputs

 

Jayasinghe R.D. and Li T.K.L., Three-rooted first permanent mandibular molars in a Hong Kong Chinese population: a computed tomographic study, Hong Kong Dental Journal. 2007, 4(2): 90-93.

 

Researcher : Jayatilake JAMS

List of Research Outputs

 

Jayatilake J.A.M.S., Samaranayake Y.H. and Samaranayake L.P., A comparative studyof candidal invasion in rabbit tongue mucosal explants and reconstituted human oral epithelium, Mycopathologia. 2008, 165(6): 373-80.

 

Researcher : Jin LJ

Project Title:

Multi-factorial Periodontal Risk Spider-web (PRS) for periodontal assessment in Hong Kong Chinese

Investigator(s):

Jin LJ, Corbet EF

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

12/2005

 

Abstract:

Periodontal disease is a family of related diseases that differ in etiology, natural history, disease progression and response to therapy but they share a common underlying chain of pathogenic events (Page et al 1997a,b). Plaque-induced periodontal diseases have traditionally been divided into two general categories: gingivitis and periodontitis. Plaque-induced gingivitis is the presence of gingival inflammation without loss of connective tissue attachment, while plaque-induced periodontitis is the presence of gingival inflammation at sites where there has been apical migration of the attachment onto the root surfaces accompanied by loss of connective tissue and alveolar bone (Armitage 2004). The primary clinical features of periodontitis include clinical attachment loss, alveolar bone loss, periodontal pocketing, and gingival inflammation (Flemmig 1999). In addition, enlargement or recession of the gingiva, bleeding on probing, and increased mobility, drifting, and/or tooth exfoliation may occur (Page & Schroeder 1976). With few exceptions, most forms of periodontitis are chronic inflammation that may progress continuously or by bursts of activity (Socransky et al., 1984; Löe et al., 1986; Jeffcoat et al., 1991). Human periodontitis is initiated and perpetuated by a small group of predominantly gram-negative, anaerobic or microaerophilic bacteria that colonize the subgingival area (Darveau et al., 1997; Page et al., 1997a,b; Flemmig 1999; Corbet & Jin 2004). Indeed, at the 1996 World Workshop on Clinical Periodontics, it was concluded that most of the periodontitis is caused by Porphyromonas gingivalis, Tannerella forsythensis (formerly Bacteroides forsythus) and Actinobacillus actinomycetemcomitans (American Academy of Periodontology 1996). In the last decade, we have come to realize that, although bacteria are essential, they are insufficient for the disease to occur nor responsible to the severity of the disease (Page et al., 1997). Manifestation and progression of periodontitis is influenced by a wide variety of determinants and risk factors, including subject characteristics, social and behavioral factors, systemic factors, genetic factors, tooth-level factors, microbial composition of dental plaque, and other emerging risk factors. Host factors such as inheritance, tobacco smoking and various other risk factors may even outweight the bacteria as determinants of whether the disease occurs and of the severity of disease outcome (Kornman et al., 1997; Page et al., 1997b; Nunn 2003; Page et al., 2003; Persson et al., 2003a,b; Corbet & Jin 2004). It has recently been shown that variations in genotypes of inflammatory cytokines and mediators may be independent risk factors for severe periodontitis, such as IL-1A and IL-1B (Kornman & di Giovine 1998) in chronic periodontitis; and IL-1RN (Parkhill et al., 2000), TNF-A (Galbraith et al., 1998) and IL-10.G (Hennig et al., 2000) in aggressive periodontitis. We recently found that a single nucleotide polymorphism in the MMP-1 promoter region of –1607 bp may be associated with generalized aggressive periodontitis in Chinese population (Cao et al., 2005). In addition, the contribution of periodontal pathogens to halitosis has been established in many studies (Lee et al., 2003; Tanaka et al., 2004; Figueiredo et al., 2005). The relationship between obesity and periodontal disease has recently been reported in Japanese and American populations (Saito et al., 2001; Al-Zahrani et al., 2003). Thus, the concept of multiple periodontal risk factors may induce a great impact on the understanding of the etiology, pathogenesis, prevention and treatment of periodontal disease. Risk is defined as the probability that an event will occur in the future, or the probability that an individual develops a given disease or experiences a change in health status during a specified interval of time (Kornman et al., 1997). A risk factor is any characteristic, behavior, or exposure with an association to a particular disease. The relationship is not necessarily causal in nature (Brownson & Pettiti 1998). From periodontal point of view, that is any factors which increase the probability of developing periodontitis, or lead to a measurable change (tooth loss) in the status of the periodontal supporting tissues (Albandar 2002). It is clear that periodontal risk assessment is potentially providing profound social and economical benefits with regard to disease prevention and control. It would be of great value for better caring of individual risk patient and determination of community treatment needs (Attström et al., 1994; Albandar 2002; Nunn 2003; Asian Pacific Society of Periodontology 2004). It has been demonstrated that not everybody is at equal risk to periodontal destruction, despite inadequate oral hygiene and hence exposure to microbial dental plaque, because of different combinations of risk factors (Löe et al 1978a,b). Currently, risk assessment for periodontitis remains subjective, empirical and variable from one clinician to another and from one patient to another (Lang et al., 2003; Page et al., 2002; Persson et al., 2003b). Utilization of periodontal risk assessment system over time would probably result in more standardized and appropriate periodontal treatment plan, effective periodontal therapy and long-term maintenance care. The Periodontal Risk Calculator (PRC) (Page et al., 2002; Page et al., 2003; Persson et al., 2003b) has been developed and tested in USA and the Periodontal Risk Assessment (PRA) (Lang et al., 2003) has been proposed for clinical application in Europe. As a country has data on risk associations for periodontal destruction in its own citizens, it would be prudent for periodontal researchers in that country to construct and test the validity of an appropriate risk assessment model for clinical use in that country (Corbet & Jin 2004). As there is no such risk assessment system in Hong Kong, the present study is therefore to develop and validate a periodontal risk assessment system, i.e. Periodontal Risk Spider-web (PRS). Aims To build up a practical periodontal risk assessment system for the assessment of periodontal conditions as well as prognosis and estimation of treatment responses in Chinese subjects with periodontal disease. Objectives - To build up a risk assessment system. i.e. the Periodontal Risk Spider-web (PRS). - To validate the relationship between the PRS assessment score and the severity of periodontal disease. - To explore the possible linkage between PRS score and periodontal treatment response. Hypotheses - The severity of periodontal diseases could be assessed by the multi-factorial Periodontal Risk Spider-web. - Periodontal treatment outcome could be estimated by the multi-factorial Periodontal Risk Spider-web.

 

Project Title:

Novel molecular mechanisms of innate host defense - implications in periodontal health and disease

Investigator(s):

Jin LJ

Department:

Dental Faculty

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

12/2005

 

Abstract:

To determine whether there is an association between subgingival bacterial colonization patterns (both beneficial and pathological species) and the expression of LBP,CD14, TLR-2, 4 and MD-2; to determine whether there is an association between bacterial infection patterns and the expression profiles of human α-defensins (hBD), as well as bactericidal/permeability-increasing protein (BPI); to assess whether there is an association between IL-1R/TLR mediated intracellular signaling pathways and bacterial infection patterns; to explore whether there is a potential association of the negative regulators of inflammatory signaling (e.g. P13K, IRAK-M, SOCS-1 and Tollip) with NF-χB mediated gene expression of cytokines, and clarify the molecular mechanisms involved in maintenance of periodontal homeostasis and pathogenesis of periodontal destruction.

 

Project Title:

Effects of periodontal treatment on serum levels of C-reactive protein and interleukin-6 in Chinese adults with chronic periodontitis

Investigator(s):

Jin LJ, Tse OD, Corbet EF

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

09/2006

 

Abstract:

Prevalence of periodontal diseases in Hong Kong Periodontal disease is one of the most common dental diseases in humans and it is also a major cause of tooth loss in adults after 40 years of age. A previous study on 372 35-44-yr-old and 537 non-institutionalized 65-74-yr-old Hong Kong Chinese showed that all subjects had one or more teeth with calculus, bleeding, or both, most teeth being so affected; and 15-17% of subjects had clinical signs of severe periodontitis. Of the older cohort, 16% were edentulous or indicated for extraction of all remaining teeth (Holmgren et al. 1994). Periodontal diseases and cardiovascular diseases: Is there a link? Chronic infections and inflammation play a major role in atherogenesis and cardiovascular disease (CVD) (Danesh et al. 1997; Loos 2005). Emerging evidence has suggested a significant moderate association between periodontal infection and CVD. Periodontitis being a chronic inflammatory and infectious disease, therefore has undergone substantial research to evaluate its relation with CVD. Approximately 42 relevant studies been published and most of them showed significant positive associations between these two diseases. Furthermore, both diseases appear to share a number of characteristics and factors in common, as they are more likely to occur in individuals who are older, male, smoker, with uncontrolled diabetics, stress, lower educational status, financial constraints, and social isolation (Offenbacher & Beck 2005). However, the association between periodontal disease and CVD has not yet been proved to be that of a causal relationship. The underlying biological mechanisms by which periodontal infection might affect the atherogenesis and contribute to CVD remain unclear. It is speculated that the inflamed and ulcerated pocket epithelium may form an easy port of entry for a number of Gram-negative and anaerobic bacteria in dental plaque biofilm. Bacteremia in periodontitis has been reported after oral examination, and periodontal pathogens have been identified in atheromatous plaques. Bacterial components, such as major outer membrane proteins and endotoxins (i.e. LPS), may be disseminated in blood as well. In response to the bacteremia and bacterial antigens that are systemically dispersed, blood cells as well as tissue cells at locations where the antigens are relocated may produce cytokines and pro-inflammatory mediators. Furthermore, the locally produced pro-inflammatory mediators in inflamed periodontal tissues, such as IL-1, TNF-α, IL-6, and PGE2, may be “dumped” into the circulation and exert systemic or distant effects. Periodontal disease has also been associated with increased carotid intima-medial wall thickness, a measure of subclinical atherosclerosis; and may independently contribute to the pathogenesis of atheroma formation. An alternative explanation for the association of periodontal diseases and CVD is that periodontal pathogens may exist in atherosclerotic lesions and actively invade human endothelial cells. Direct invasion of vessel walls by oral pathogens could trigger an inflammatory response that may translate into endothelial dysfunction. A recent study showed that periodontitis may be associated with the development of early atherosclerotic carotid lesions (Söder et al. 2005). CRP and IL-6 Systemic inflammation may represent an underlying mechanism that links periodontal disease with CVD. The potential role of periodontal disease as a possible chronic source of systemic infection and inflammation is supported by findings indicating an association of periodontal disease with elevated serum levels of CRP and IL-6 (Loos 2005). Plasma levels of CRP and IL-6 were consistently higher in periodontitis patients than in healthy controls (Loos et al. 2000). Currently, CRP and IL-6 serve as sensitive markers for evaluation of the inflammatory status of an individual (Ridkeret al. 1997; Danesh 2000). CRP has proved to be the strongest and most significant predictor of the risk of future cardiovascular events among several plasma variables. Slightly elevated (>0.3mg/l up to 3mg/l) and chronically present levels of CRP were determined to have predictive value for occurrence of a cardiovascular event (Rosenson & Koenig 2003; Ridker et al. 2004). A recent consensus conference of the American Heart Association and the Centre for Diseases Control focused on the clinical utility of markers of inflammation in the management of CVD risk. In addition to the classical risk estimation based on well-defined markers (e.g. smoking, obesity, hyperlipidaemia, hypertension, diabetes, age and gender), three risk categories according to serum CRP levels were identified: subjects with CRP concentration less than 1mg/l are considered to be at low risk, whereas those with concentrations in the 1-3mg/l range were assigned a medium risk, and those with concentrations more than 3mg/l are considered to be at high risk for future cardiovascular disease and events (Pearson et al. 2003). The effect of periodontal therapy Recent studies have shown that control of periodontal infection could reduce serum levels of CRP and IL-6 (Ready et al. 2004; Offenbacher & Beck 2005). These markers appear to be predictive and in some instance causally related to atherosclerosis, myocardial infarction, stroke, and thrombosis. Studies on serum levels of CRP and IL-6 may therefore contribute to further understanding of the association between periodontal infection and cardiovascular diseases, thrombotic events and atherosclerosis. Recent studies demonstrated that patients with severe periodontal disease exhibited endothelial dysfunction through assessment of flow-mediated dilation of brachial artery and CRP levels, and endothelial dysfunction could be reversible after successful periodontal treatment, with a significant reduction of CRP levels comparable to those in control group (Amar et al. 2003; Seinost et al. 2005). There is increasing evidence from clinical trials that the improvement of endothelial function may translate into lower rates of cardiovascular events (Bonetti et al. 2003). Aims of the study Currently, there are no similar studies on Chinese population. The present study therefore aims to investigate the effects of periodontal treatment on serum levels of selected acute-phase reactants in Chinese adults with chronic periodontitis. The objectives of the present study are i) to determine the association of serum levels of CRP and IL-6 with the severity of periodontal disease in Chinese adults with chronic periodontitis; ii) to investigate the effects of non-surgical periodontal treatment on the serum levels of CRP and IL-6; and iii) to study the association between changes in serum levels of CRP and IL-6 with treatment responses to non-surgical periodontal therapy.

 

List of Research Outputs

 

Berezow A.B., Jin L.J. and Darveau R.P., The molecular basis of host defense mechanisms in oral disease, In: Molecular Oral Microbiology. ed. Anthony H. Rogers;. Norwich (UK), Caister Academic Press/Horizon Scientific Press, 2008, p.237-255.

 

Jin L.J., An update on periodontal aetiopathogenesis and clinical implications, 19th Convocation of Royal Australian College of Dental Surgeons (RACDS) conjoint with the College of Dental Surgeons of Hong Kong (CDSHK), May 30 - June 2. Hong Kong, 2008.

 

Jin L.J. and Wang C.Y., An update on periodontal infections, systemic inflammatory biomarkers, and cardiovascular disease, Chinese Journal of Dental Research. 2007, 10: 7-13.

 

Jin L.J., Associate Editor, Prosthodontic Research & Practice (Japan). 2007.

 

Jin L.J., Clinical management of subjects with advanced periodontitis, Sichun University West China School of Stomatology, August 31. Chengdu, China, 2007.

 

Jin L.J., Deputy Editor, Hong Kong Dental Journal. 2007.

 

Jin L.J., Editorial Board Member (overseas), Chinese Journal of Dental Research. 2007.

 

Jin L.J., Editorial Board Member, Asian Journal of Oral & Maxillofacial Surgery. 2007.

 

Jin L.J., Editorial Board Member, International Dental Journal. 2008.

 

Jin L.J., Editorial Board Member, Journal of Periodontal Research. 2008.

 

Jin L.J., Evidence-based management of periodontitis patients, Annual Meeting of the Stomatological Society of Wenzhou, November 10. Wenzhou, China, 2007.

 

Jin L.J., Fellowship in Dental Surgery ad hominem, Royal College of Surgeons of Edinburgh (FDS RCS Edin ad hominem), November 23, 2007. 2007.

 

Jin L.J., Hiroshima University Award (Co-supervisor for Dr Jayampath Seneviratne, a PhD student), Hiroshima Conference on Education and Science in Dentistry, Hiroshima, Japan, October 6 -7, 2007. . 2007.

 

Jin L.J., Honorary Professor, Wenzhou Medical School, Institute of Stomatology, Wenzhou, China, November 2007. 2007.

 

Jin L.J., Member of Editorial Advisory Board, Journal of Periodontology. 2007.

 

Jin L.J., Oral and systemic health - an update, Zhejiang University School of Stomatology, December 14. Hangzhou, China, 2007.

 

Jin L.J., Oral health and general health, The affiliated Zhejiang 2nd Hospital of Zhejiang University School of Medicine, December 13. Hangzhou, China, 2007.

 

Jin L.J., Outstanding Poster Presentation Award (Co-supervisor for Dr. Parahitiyawa N Bandara, a PhD student), 2nd International Conference on Evidence-based Advanced Dentistry, Hong Kong, November 16-19, 2007.. 2007.

 

Jin L.J., Lu Q., Samaranayake L.P. and Darveau R., P. gingivalis Lipopolysaccharide with different structures differentially modulates innate responses, Journal of Dental Research. 2007, 86 (Spec Iss B): IO-14.

 

Jin L.J., PBL experience at the Faculty of Dentistry, The University of Hong Kong, Peking University School of Stomatology, December 17. Beijing, China, 2007.

 

Jin L.J., Periodontal and systemic health - Current evidence, clinical implications and perspectives, Tour lecturing at the National University of Taiwan, Taipei Medical University and National Defense Medical Center & Tri-Service General Hospital, as well as Lecturing at the Meeting of Key Opinion Leaders in Taipei, Taichung and Kaoshiung, August 27 - 30. Taiwan, 2007.

 

Jin L.J., Periodontal care as the foundation of general dental practice, Hong Kong Dental Association Newsletter. 2008, March: 18-20.

 

Jin L.J., Periodontal care as the foundation of general dental practice, The 306 Hospital of PLA, June 23. Beijing, China, 2008.

 

Jin L.J., Periodontal care: the foundation of general dental practice, The Hong Kong Dental Association Monthly Meeting, March 19. Hong Kong, 2008.

 

Jin L.J., Periodontal etiopathogenesis - an update and clincial implications, Centro Escolar University, Centennial Year Anniversary, April 25. Manila, Philippines, 2008.

 

Jin L.J., Periodontal infection as a silent risk factor for cardiovascular disease, 2nd International Conference on Evidence-based Advanced (Organized by the Faculty of Dentistry, The University of Hong Kong and CDSHK), November 16 - 19. Hong Kong, 2007.

 

Jin L.J., Periodontal infections and cardiovascular disease - Scientific evidence and clinical implications, Faculty of Chinese Medicine, Macau University of Science & Technology, April 9. Macau, 2008.

 

Jin L.J., Periodontal infections, systemic inflammation and cardiovascular disease - current evidence and perspectives, 7th Asian Pacific Society of Periodontology, September 21 - 22. Beijing, China, 2007.

 

Jin L.J., Periodontal infections, systemic inflammation and cardiovascular disease: current evident and perspectives, In: A perspective of periodontal systemic relationships for the Asian Pacific region, ed. Bartold PM, Ishikawa I, Zhang J;. Adelaide, Asian Pacific Society of Periodontology, 2008, p.114-121.

 

Jin L.J., Reviewer (ad hoc), Frontiers in Bioscience. 2008.

 

Jin L.J., Reviewer (ad hoc), Journal of Dental Research. 2008.

 

Jin L.J., Reviewer (ad hoc), Mycopathologia. 2008.

 

Jin L.J., The University of Hong Kong - Peking Conjoint International Postgraduate Programme in Periodontology, U21 Health Sciences Dentistry Meeting, September 27-29. Hong Kong, 2007.

 

Jin L.J., The University of Hong Kong launches a novel international postgraduate program in periodontology conjointly with Peking University in Beijing, Hong Kong Dental Journal. 2007, 4: 134-136.

 

Jin L.J., Travel Awards (Co-supervisor for Dr. Jayampath Seneviratne, a PhD student), IADR/Colgate Research in Prevention. 2008.

 

Jin L.J., Visiting Professor, Sun Yat-Sen University Guanghua College of Stomatology, Guangzhou, China, May 15, 2008. 2008.

 

Leung W.K., Siu S.C., Chu F.C.S., Wong K.W., Jin L.J., Sham A.S.K., Tsang P.C.S. and Samaranayake L.P., Oral health status of low-income, middle-aged to elderly Hong Kong Chinese with type 2 diabetes mellitus , Oral Health & Preventive Dentistry. 2008, 6: 105-118.

 

Lu Q., Jin L.J., Samaranayake L.P. and Darveau R.P., Outstanding Oral Presentation Award (Primary supervisor for Dr. Q. Lu, a postdoctorial fellow), 2nd International Conference on Evidence-based Advanced Dentistry, Hong Kong, China, 16-19 November 2007. 2007.

 

Lu Q., Samaranayake L.P., Darveau R.P. and Jin L.J., Outstanding Poster Presentation Award (Primary supervisor for Dr. Q. Lu, a postdoctorial fellow), Inaugural Conjoint Dental Scientific Meeting - The University of Hong Kong and Wuhan University, China, 10-11 May, 2008. 2008.

 

Lu Q., Jin L.J., Samaranayake L.P. and Darveau R., P. gingivalis lipopolysaccharides upregulate protease-activated receptor expression in gingival epithelium, Journal of Dental Research. 2007, 86 (Spec Iss B): IP-130.

 

Mei L., Fang H.H.P., Zhang T., Jin L.J. and Yip H.K., The use of chlorhexidine in reducing the cariogenicity of oral microbial biofilm with caries free and high risk of caries. , the Inaugural Conjoint Dental Scientific Meeting The University of Hong Kong and Wuhan University.. China, 2008, 38.

 

Ren L., Jin L.J. and Leung W.K., The in vivo expression patterns of IL-1b and IL-10 in chronic periodontitis, Chinese Journal of Stomatological Research. 2007, 1: 21-24.

 

Seneviratne C.J., Wang Y., Jin L.J. and Samaranayake L.P., A clue to drug resistance in Candida biofilm proteome?, Journal of Dental Research. 2007, 86 (Spec Iss B): IO-36.

 

Seneviratne C.J., Wang Y., Jin L.J., Abiko Y. and Samaranayake L.P., Candida albicans biofilm formation is associated with increased anti-oxidative capacities, Proteomics. 2008, 8(14): 2936-47.

 

Shum I.H.Y., Jin L.J., Leung P.C., Lau E., Kwok A., Corbet E.F. and Orwoll E.S., Association of periodontal disease with osteoporosis/osteopenia in Chinese Men, Journal of Dental Research. 2007, 86 (Spec Iss B): IP-126.

 

Tsang P.C.S., Chu F.C.S., Leung W.K., Jin L.J., Samaranayake L.P. and Siu S.C., Phospholipase, proteinase and haemolytic activities of Candida albicans isolated from oral cavities of patients with type 2 diabetes mellitus, Journal of Medical Microbiology. 2007, 56: 1393-1398.

 

Tse O.D., Jin L.J. and Corbet E.F., Treatment of periodontitis and CRP serum level in Chinese adults, Journal of Dental Research. 2007, 86 (Spec Iss B): IP-143.

 

Zhu G., Li C., Cao Z., Corbet E.F. and Jin L.J., Toll-like receptors 2 and 4 gene polymorphisms in a Chinese population with periodontitis, Quintessence International. 2008, 39: 217-226.

 

Researcher : Ke J

List of Research Outputs

 

Ke J., Zheng L. and Cheung L.K., Characterization of rabbit bone marrow stromal cells after cryopreservation, Inaugural Conjoint Dental Scientific Meeting, The University of Hong Kong and Wuhan University. 10-11 May, 2008, China. 2008, p. 36.

 

Researcher : King NM

Project Title:

Aesthetic concerns of adolescents and young adults in relation to development defects of enamel

Investigator(s):

King NM, Lo ECM

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2002

 

Abstract:

To develop a set of standardized photographic images showing permanent anterior teeth with developmental enamel defects of different types suitable for investigating people's perception of the aesthetics; to determine the aesthetic perception and the need for treatment of adolescents and young adults in relation of different enamel defects in Chinese (Hong Kong); to evaluate the effect of gender, age, dental training (knowledge) and dental impairment on people's aesthetic perception of developmental enamel defects.

 

Project Title:

Permeability of dentin adhesives

Investigator(s):

King NM, Tay FRCM, Yiu CKY, Cheong CHL

Department:

Dental Faculty

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

10/2003

 

Abstract:

To evaluate the micro-tensile bond strength (muTBS) and permeability of different dentin bonding systems over time in water and in oil; to evaluate the ultra-structural morphology of the resin-dentin interfaces of different bonding systems over time in water and in oil using SEM and TEM; to determine the extent of silver nitrate penetration into four versions of resin blends with increasing degrees of hydrophilicity after long-term storage; to determine the ultimate tensile bond strength of the four resin blends in (3) after long-term storage; to advance basic science research in the improvement of the long-term durability of dentin bonding systems for the restoration of teeth.

 

Project Title:

Remineralization ability of hydroxyapatite containing dentifrices

Investigator(s):

King NM, Itthagarun A, Ng YW

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2003

 

Abstract:

To explore an in vitro pH cycling study of the progression of initial enamel caries lesion treated with commercially available dentifrices contain hydroxyapatite crystals.

 

Project Title:

The effects of different concentrations of water on the bonding efficacy to dentin of self-etching primers

Investigator(s):

King NM, Tay FRCM

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

 

Abstract:

To create experimental self-etching primers using one acidic resin monomer, one hydrophilic resin monomer, a fixed amount of ethanol and variable amounts of water for simultaneous etching and priming of dentin.

 

Project Title:

Microtensile bond testing of luting cements to dentin

Investigator(s):

King NM, Yiu CKY, Hiraishi N

Department:

Dental Faculty

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

07/2007

 

Abstract:

Objectives: (1) To compare the microtensile bond strength of two self-etch resin luting cements to dentin prepared with either a coarse or superfine diamond bur. (2) To evaluate the effect of simulated pulpal pressure on permeability and microtensile bond strength of two self-etch resin luting cements to dentin. (3) To evalauate the effect of seating pressure on the microtensile bond strength of two self-etch resin luting cements to perfused dentin. The null hypothesis: (1) There is no difference in the microtensile bond strength of self-etch resin luting cements to dentin prepared with different surface treatments. (2) The increase in adhesive permeability induced by simulated pulpal pressure has no effect on microtensile bond strength of self-etch resin luting cements to dentin. (3) Seating pressure has no effect on the microtensile bond strength of self-etch resin luting cements to perfused dentin. Key issues and problems: 1. Tooth-colored resin composites have become the primary aesthetic restorative material to replace tooth structure lost through dental caries and trauma. Indirect composite restorations are preferred over direct restorations because of their improved mechanical properties and reduced polymerization contraction stress. A key element for the success of these indirect bonded restorations is the intimate interaction of the luting cement with dentin, which depends on the wetting ability and the extent to which these adhesives penetrate the tooth surface. The wetting ability of the luting cement is influenced by the surface topography of the prepared tooth surface. Smear layer, containing denatured collagen fibrils and hydroxyapatite crystals, is formed on the tooth surface following rotary instrumentation. Its thickness on prepared dentin surface is influenced by the types of burs used. Coarse diamond bur produced a thicker smear layer, which can interfere bonding with luting cement. Hence, information on the effect of different burs on bond strength of self-etch resin luting cement to dentin is essential for the clinical success of indirect restorations. 2. While many studies have compared the tensile or shear bond strength of resin luting cements to dentin, very few have assessed the bond strength under simulated pulpal pressure. The presence of a positive pulpal pressure may dilute the luting cement when bonding is performed on deep dentin and result in a weaker adhesive interface. Thus, in order to predict the clinical behaviour of these cements on vital teeth, we plan to examine the effect of simulated pulpal pressure on permeability and bond strength of luting cements to dentin. 3. Water sorption from underlying dentin is further facilitated by the increased concentration of hydrophilic ionic resin monomers in self-etch luting cement and their longer setting time. Recent studies have indicated that pressure application during the setting of resin cement suppress the absorption of water and improves bond strength. However, it is not known whether similar improvement in bond strengths could be observed in perfused teeth. Hence, we decide to examine the effect of sustained seating pressure on bond strength of luting cement to perfused dentin.

 

List of Research Outputs

 

Anthonappa R.P., Yiu C.K.Y. and King N.M., A novel combination of dens evaginatus and dens invaginatus in a single tooth - review of the literature and a case report., J Clin Paediatr Dent. 2008, 32(3): 239-242.

 

Anthonappa R.P., Omer R.S.M. and King N.M., Characteristics of 283 supernumerary teeth in southern Chinese children, Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2008, 105: e48-e54.

 

Cheng R.H.W., Leung W.K., Corbet E.F. and King N.M., Oral health status of adults with Down syndrome in Hong Kong, Special Care in Dentistry. 2007, 27: 134-138.

 

Chung C.W.M., Yiu C.K.Y., King N.M. and Hiraishi N., Effect of saliva contamination on bond strength of luting cements to dentine., Inaugural University of Hong Kong - Wuhan University Conjoint Scientific Meeting, Donggguan, China, May 10. 2008, Abstract P-21.

 

Dhanpal P.K., Yiu C.K.Y. and King N.M., A review of dentin adhesives in pediatric dentistry, Hong Kong Dental Journal. 2007, 4(2): 80-89.

 

Dhanpal P.K., Yiu C.K.Y., King N.M., Tay F.R.C.M. and Hiraishi N., Effect of temperature on water sorption and solubility of dental adhesive resins, Second International Conference on Evidence-based Advanced Dentistry, Conjoint Congress 16-19 November, Hong Kong. 2007. P.68 Abstract P-26.

 

Ekambaram M., Yiu C.K.Y. and King N.M., An unusual case of double teeth with facial and lingual talon cusps., Oral Surgery, Oral Medicine, Oral Radiology and Endodontology. 2008, 105: e63-67.

 

Hiraishi N., Yiu C.K.Y., King N.M., Tay F.R.C.M. and Pashley D.H., Chlorhexidine release and water sorption characterisitcs of chlorhexidine-incorporated hydrophobic/hydrophilic resins., Dent Materials. 2008, 24: 1391-9.

 

Hiraishi N., Yiu C.K.Y., King N.M., Tay F.R.C.M. and Pashley D.H., Chlorhexidine release and water sorption characteristics of chlorhexidine-incorporated dental adhesive resins, Second International Conference on Evidence-based Advanced Dentistry, Conjoint Congress 16-19 November, Hong Kong. 2007. P.71 P-30.

 

Hiraishi N., Yiu C.K.Y. and King N.M., Effect of acid etching time on bond strength of an etch-and-rinse adhesive to primary tooth dentine affected by amelogenesis imperfecta. , International Journal of Paediatric Dentistry. 2008, 18(3): 224-230.

 

Hiraishi N., Yau J.Y., Loushine R.J., Armstrong S.R., Weller R.N., King N.M., Pashley D.H. and Tay F.R.C.M., Susceptibility of a polycaprolactone-based root canal filling material to degradation: III. Turbdimetric evaluation of enzymatic hydrolysis., J Endod. 2007, 33(8): 952-956.

 

Hiraishi N., Breschi L., Prati C., Ferrari M., Tagami J. and King N.M., Technique sensitivity associated with air-drying of HEMA-free, single-bottle,one-step self-etch adhesives., Dent Mater. 2007, 23(4): 498-505.

 

Itthagarun A., King N.M. and Rana R., Effects of child formula dentifrices on artificial caries like lesions using in vitro pH-cycling: preliminary results., International Dental Journal. 2007, 57: 307-313.

 

Itthagarun A., Thaveesangpanich P., King N.M., Tay F.R.C.M. and Wefel J.S., Effects of different amounts of a low fluoride toothpaste on primary enamel lesion progression: a preliminary study using in vitro pH-cycling system. , Eur Arch Paediatr Dent. 2007, 8(1): 69-73.

 

King N.M., Tongkoom S., Itthagarun A., Wong H.M. and Lee C.K., A catalogue of anomalies and traits of the primary dentition of Southern Chinese., Journal of Clinical Pediatric Dentistry. 2007, 32(2): 139-146.

 

Kumar V.L.N., Itthagarun A. and King N.M., The effect of casein phosphopeptide-amorphous calcium phosphate on remineralization of artificial caries-like lesions: an in vitro study, Australian Dental Journal. 2008, 53: 34-40.

 

Lai M.C., King N.M. and Wong H.M., Dental development of Chinese children with cleft lip and palate, The Cleft Palate-Craniofacial Journal. 2008, 45(3): 289-296.

 

Lee C.K., King N.M., Lo E.C.M. and Cho S.Y., Management of supplemental permanent maxillary lateral incisors in association with talon cusp on the primary predecessors: A report of 3 cases, Journal of Dentistry for Children. 2008, 75: 59-63.

 

McGrath C.P.J., Pang H.H., Lo E.C.M., King N.M., Hagg E.U.O. and Samman N., Translation and evaluation of a Chinese version of the child oral health-related quality of life measure., Int J Paediatr Dent. 2008, 18: 267-274.

 

Peerzada F., Yiu C.K.Y., King N.M. and Hiraishi N., Effect of surface preparation on bond strength of luting cement to dentine, Inaugural University of Hong Kong - Wuhan University Conjoint Scientific Meeting, Donggguan, China. May 10, 2008. P-22.

 

Rana R., Itthagarun A. and King N.M., Effects of dentifrices on artificial caries like lesions: an in-situ pH cycling study, International Dental Journal. 2007, 57 (4): 243-248.

 

Tay F.R.C.M., Pashley D.H., Loushine R.J., Kuttler S., Garcia-Godoy F., King N.M. and Ferrari M., Susceptibilityof a polycaprolactone-based root canal filling material to degradation. Evidence of biodegradation from a stimulated field test., Am J Dent. 2007, 20(6): 365-369.

 

Wong H.M. and King N.M., Dental trauma management awareness of kindergarten teachers in Hong Kong, XV World Congress on Dental Traumatology. 2008.

 

Wong H.M. and King N.M., Knowledge of dental trauma management: an interview of 100 kindergarten teachers, Second International Conference on Evidence-based Advanced Dentistry. 2007.

 

Yiu C.K.Y., Hiraishi N., King N.M. and Tay F.R., Effect of dentinal surface preparation on bond strength of self-etching adhesives, Journal of adhesive dentistry. 2008, 10: 173-182.

 

Yiu C.K.Y., Hiraishi N., King N.M. and Tay F.R.C.M., Effect of pulpal pressure on bond strength of luting cements to dentin, Second International Conference on Evidence-based Advanced Dentistry, Conjoint Congress 16-19 November, Hong Kong. 2007. P.38 O-17.

 

Researcher : Lai SML

List of Research Outputs

 

Lai S.M.L., AGM Lecture, Is implant the panacea to replace missing teeth. 2008.

 

Lai S.M.L., Zee K.Y. and Corbet E.F., Implant reconstructions in periodontally susceptible patients, Hong Kong Dental Journal. 2008, 5: 11-18.

 

Researcher : Lane T

List of Research Outputs

 

Dyson J.E., Yiu C.K.Y., Samaranayake L.P., Bridges S.M., Lane T., Chan J.P.S., Cheng S.W. and Leung R.T.C., Problem-based learning in dentistry. Hong Kong, Faculty of Dentistry, The University of Hong Kong, 2008.

 

Researcher : Lang NP

List of Research Outputs

 

Burkhardt R., Preiss A., Joss A. and Lang N.P., Influence of suture tension to the tearing characteristics of the soft tissues: an in vitro experiment, Clin Oral Implants Res. 2008, 19: 314-9.

 

Burkhardt R., Joss A. and Lang N.P., Soft tissue dehiscence coverage around endosseous implants: a prospective cohort study, Clin Oral Implants Res. 2008, 19: 451-7.

 

Cafiero C., Annibali S., Gherlone E., Grassi F.R., Gualini F., Magliano A., Romeo E., Tonelli P., Lang N.P. and Salvi G.E., Immediate transmucosal implant placement in molar extraction sites: a 12-month prospective multicenter cohort study, Clin Oral Implants Res. 2008, 19: 476-82.

 

Salvi G.E., Fürst M.M., Lang N.P. and Persson G.R., One-year bacterial colonization patterns of Staphylococcus aureus and other bacteria at implants and adjacent teeth, Clin Oral Implants Res. 2008, 19: 242-8.

 

Researcher : Lee AMP

List of Research Outputs

 

Lee A.M.P., Predictability of immediate implant placement after tooth extraction, OSSTEM Meeting 2007: Early & Esthetic, 16-9-2007, The Ballroom, Langham Hotel Hong Kong. 2007.

 

Researcher : Lee CK

List of Research Outputs

 

King N.M., Tongkoom S., Itthagarun A., Wong H.M. and Lee C.K., A catalogue of anomalies and traits of the primary dentition of Southern Chinese., Journal of Clinical Pediatric Dentistry. 2007, 32(2): 139-146.

 

Lee C.K., King N.M., Lo E.C.M. and Cho S.Y., Management of supplemental permanent maxillary lateral incisors in association with talon cusp on the primary predecessors: A report of 3 cases, Journal of Dentistry for Children. 2008, 75: 59-63.

 

Lee C.K., McGrath C.P.J., Wong R.W.K. and Rabie A.B.M., Patient's perceptions regarding microimplant as anchorage in orthodontics, Angle Orthodontist. 2008, 78: 228-233.

 

Lo E.C.M., Loo E.K.Y. and Lee C.K., Dental caries situation of Hong Kong kindergarten children, Journal of Dental Research. 2007, 86 (Spec Iss B): IP-072.

 

Researcher : Lee CK

List of Research Outputs

 

King N.M., Tongkoom S., Itthagarun A., Wong H.M. and Lee C.K., A catalogue of anomalies and traits of the primary dentition of Southern Chinese., Journal of Clinical Pediatric Dentistry. 2007, 32(2): 139-146.

 

Lee C.K., King N.M., Lo E.C.M. and Cho S.Y., Management of supplemental permanent maxillary lateral incisors in association with talon cusp on the primary predecessors: A report of 3 cases, Journal of Dentistry for Children. 2008, 75: 59-63.

 

Lee C.K., McGrath C.P.J., Wong R.W.K. and Rabie A.B.M., Patient's perceptions regarding microimplant as anchorage in orthodontics, Angle Orthodontist. 2008, 78: 228-233.

 

Lo E.C.M., Loo E.K.Y. and Lee C.K., Dental caries situation of Hong Kong kindergarten children, Journal of Dental Research. 2007, 86 (Spec Iss B): IP-072.

 

Researcher : Lee LTK

List of Research Outputs

 

Lee L.T.K., Yeung R.W.K., Wong M.C.M. and McMillan A.S., Diagnostic sub-types, psychological distress and psychosocial dysfunction in southern Chinese people with temporomandibular disorders, Journal of Oral Rehabilitation. 2008, 35(3): 184-90.

 

Researcher : Leung KCM

Project Title:

Oral yeast and anaerobic bacteria level in patients with Sjögren's syndrome after saliva stimulation

Investigator(s):

Leung KCM, McMillan AS, Leung WK

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

 

Abstract:

To quantify and compare the colonization of yeast and anaerobic bacteria in oral rinse, supra-gingival plaque and stimulated saliva harvested from SS patients before and after saliva stimulation by cevimeline; to obtain precise identification of oral yeast and lactobacillus; to compare the virulence of Candida albicans before and after saliva stimulation.

 

Project Title:

Salivary microbes in patients with Sjögren's syndrome

Investigator(s):

Leung KCM, Leung WK, McMillan AS

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

12/2005

 

Abstract:

Sjögren's syndrome (SS) is one of the most common auto-immune disorders which affects 3-4% of adults, middle-aged women in particular. Major pathological changes involve lymphocyte and plasma cell infiltration of the salivary, lacrimal and other exocrine glands with progressive destruction of gland acini. The major oral complication of SS is severe dryness of the mouth (xerostomia) resulting in a shift of the oral microbial equilibrium to become more cariogenic, ie. increased level of Lactobacillus and Streptococcus mutans. Thus, SS subjects have a higher susceptibility to dental caries and early tooth loss. Objectives: 1. to quantify the colonization of Streptococci and Lactobacilli in whole saliva of SS patients 2. to identify, characterize and speciate the Streptococci and Lactobacilli species 3. to study the association of the level of salivary Streptococci and Lactobacilli species in of SS patients with concurrent caries status

 

List of Research Outputs

 

Leung K.C.M., Oral health condition and saliva flow in southern Chinese with Sjogren's syndrome, Department of Rheumatology, Queen Mary Hospital. 2008.

 

Leung K.C.M., McMillan A.S., Cheung B.P.K. and Leung W.K., Sjögren's syndrome sufferers have increased oral yeast levels despite regular dental care, Oral Diseases. 2008, 14: 163-173.

 

Leung K.C.M., Leung W.K. and McMillan A.S., Supra-gingival microbiota in Sjögren's syndrome, Clinical Oral Investigations. 2007, 11: 415-423.

 

Leung K.C.M., McMillan A.S., Wong M.C.M., Leung W.K., Mok T.M.Y. and Lau C.S., The efficacy of cevimeline hydrochloride in the treatment of xerostomia in Sjögren's syndrome in southern Chinese patients: a randomised double-blind, placebo-controlled crossover study, Clinical Rheumatology. 2008, 27: 429-436.

 

Pow E.H.N. and Leung K.C.M., Recent innovations in dental implantology, Expressions. 2008, 2: 11.

 

Pow E.H.N., Botelho M.G., Chow T.W., Dias A.P.L.H., Dyson J.E., Leung K.C.M. and McMillan A.S., Student's manual to the BDS V Prosthodontic Clinical Skills and Technology Course in Oral Rehabilitation 2007-2008. Hong Kong, 2007, 1-76.

 

Pow E.H.N., Botelho M.G., Chow T.W., Dias A.P.L.H., Dyson J.E., Leung K.C.M. and McMillan A.S., Teacher's manual to the BDS V Prosthodontic Clinical Skills and Technology Course in Oral Rehabilitation 2007-2008. Hong Kong, 2007, 1-89.

 

Researcher : Leung MYY

List of Research Outputs

 

Leung M.Y.Y. and Cheung L.K., Outstanding Oral Abstract Presentation Award at the 19th Convocation of the Royal Australasian College of Dental Surgeons, Hong Kong, May 29 - June 2, 2008, Hong Kong. 2008.

 

Leung M.Y.Y., Young Lecturer Award of the 19th Convocation of the Royal Australasian College of Dental Surgeons, Hong Kong, May 2008. 2008.

 

Researcher : Leung RTC

List of Research Outputs

 

Dyson J.E., Yiu C.K.Y., Samaranayake L.P., Bridges S.M., Lane T., Chan J.P.S., Cheng S.W. and Leung R.T.C., Problem-based learning in dentistry. Hong Kong, Faculty of Dentistry, The University of Hong Kong, 2008.

 

Researcher : Leung VWH

Project Title:

Study of the calcium-phosphate system artificial oral environments

Investigator(s):

Leung VWH, Darvell BW

Department:

Dental Faculty

Source(s) of Funding:

Other Funding Scheme

Start Date:

01/1994

 

Abstract:

In parallel with the numerical modelling work for calcium-phosphate in human saliva, direct studies of the stabilities of the calcium phosphate systems in various aqueous ionic media re being undertaken to provide experimental tests of the theoretical predictions.

 

Project Title:

Solution ionic effects on the demineralisation of calcified hard tissue

Investigator(s):

Leung VWH

Department:

Dental Faculty

Source(s) of Funding:

Other Funding Scheme

Start Date:

01/1994

 

Abstract:

To study the aqueous solution ionic effects on the demineralisation rate of dental calcified hard tissue.

 

Project Title:

Further development of an artificial saliva

Investigator(s):

Leung VWH, Darvell BW

Department:

Dental Faculty

Source(s) of Funding:

Other Funding Scheme

Start Date:

01/1994

 

Abstract:

To further develop an artificial saliva for the laboratory testing of the performance of materials serving in the oral environment.

 

Project Title:

Numerical modelling of the calcium-phosphate system in human saliva

Investigator(s):

Leung VWH, Darvell BW

Department:

Dental Faculty

Source(s) of Funding:

Other Funding Scheme

Start Date:

01/1994

 

Abstract:

Use of RAMESES, software designed for the solution of multiple equilibrium equations, to model the chemistry of saliva with a view to understanding the solid / solution interactions of the calcium-phosphate system.

 

Project Title:

Legal aspects of dentsitry

Investigator(s):

Leung VWH

Department:

Dental Faculty

Source(s) of Funding:

Other Funding Scheme

Start Date:

07/2001

 

Abstract:

To study the legal implications on the practice of dentists and the handling of dental materials by the dental profession.

 

List of Research Outputs

 

Researcher : Leung WK

Project Title:

A randomized clinical trial using Rofecoxib as an adjunct to promote periodontal healing in non-surgical mechanical therapy on smokers

Investigator(s):

Leung WK

Department:

Dental Faculty

Source(s) of Funding:

Other Funding Scheme

Start Date:

12/2003

 

Abstract:

To carry out randomized clinical trial using Rofecoxib as an adjunct to promote periodontal healing in non-surgical mechanical therapy on smokers.

 

Project Title:

Molecular detection of Actinobacillus actinomycetemcomitans: clarification it's role in periodontitis

Investigator(s):

Leung WK

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

10/2005

 

Abstract:

Hypothesis - PCR based Actinobacillus actinomycetemcomitans (Aa) detection is reliable; the currently available most popular detection method by Ashimoto (et al. 1996), however, need vigorous quality control and cross-reaction tests; - Aa prevalence in health, disease and periodontally treated condition are different and could be used in monitor of host’s periodontal health situation Objectives 1. to isolate and characterize bacterial strains from subgingival plaque of age- and sex-matched individuals with various periodontal health or diseased conditions using the Ashimoto PCR Aa detection protocol (Ashimoto et al. 1996); 2. to conduct complete 16S rDNA gene sequence analysis of all isolates identified; 3. Characterization, using cloning, sequencing and PCR techniques, from the subgingival plaque samples from the above mentioned subjects, the predominantly detectable complete 16S rDNA gene sequence which cross reacts with the Ashimoto PCR Aa detection primers; 4. taking data from objective 2 and 3 in consideration, to verify or identify the best 16S rDNA based PCR method to detect presence of Aa.

 

Project Title:

Polymorphisms of Fc Gamma receptor Genes in Chinese Chronic Periodontitis Patients

Investigator(s):

Leung WK, Song Y

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

09/2006

 

Abstract:

Background: Human periodontitis is an infectious disease characterized by chronic inflammatory destruction of tooth supporting tissues. The tissue destruction is the result of unfavourable interactions between periodonto-pathogenic bacteria and host immuno-inflammatory responses in susceptible individuals. This complex chronic disease process is characterized by involvement of multiple factors, biological pathways and multiple disease modifying genes in a variety of fashions leading to similar clinical phenomena/presentation, i.e. in the case of periodontitis, destruction of periodonotium supporting tooth. More and more evidence avaible indicated that increase periodontal disease risk is associated with genetic polymorphism of more than one gene. Previous investigations of this group in a "candidate gene experimental approach" revealed that possible association between homogeneous geneotypes of single-nucleotide polymorphisms (SNP) rs1801274 (structural gene) and genotype CC in rs13878 (promotor region) in Fc gamma receptor 2A (FCGR2A) gene is associated with periodontitis (Chai et al, 2006). The current proposal is an attempt to clarify and characterize this genetic association between FCG receptor genes and human periodontitis.Objective: This proposal focuses on FCG receptor genes loci of Chinese periodontitis patients to identify haplotype tag SNPs, evaluation of linkage disequilibrium (LD), and association studies of the gene cluster with periodontitis.Significance: Undesirable FCGR genotypes appeared to be one significant predisposing factor in human periodontitis. Understanding the extent to which variation in the gene determines inter-individual variation in FCGR mediated immune response may turn out to be useful for preventing suceptible individuals from getting the disease or clinical management of individuals already affected by periodontitis.

 

List of Research Outputs

 

Chai L., Leung W.K., Zee K.Y. and Song Y., Association between FCGR3A polymorphisms and periodontitis in Hong Kong Chinese, Journal of Dental Research. 2007, 86 (Spec Iss B): IP-131.

 

Chan P.S., Ho J.C.S., Zee K.Y., Corbet E.F. and Leung W.K., The adjunctive use of Chinese medicine in non-surgical periodontal therapy, Journal of Dental Research. 2007, 86 (Spec Iss B): IP-141.

 

Cheng R.H.W., Leung W.K. and Corbet E.F., Non-surgical periodontal therapy with adjunctive chlorhexidine use in adults with Down syndrome: A prospective case series, Journal of Periodontology (1970 : Online). 2008, 79: 379-385.

 

Cheng R.H.W., Leung W.K., Corbet E.F. and King N.M., Oral health status of adults with Down syndrome in Hong Kong, Special Care in Dentistry. 2007, 27: 134-138.

 

Leung K.C.M., McMillan A.S., Cheung B.P.K. and Leung W.K., Sjögren's syndrome sufferers have increased oral yeast levels despite regular dental care, Oral Diseases. 2008, 14: 163-173.

 

Leung K.C.M., Leung W.K. and McMillan A.S., Supra-gingival microbiota in Sjögren's syndrome, Clinical Oral Investigations. 2007, 11: 415-423.

 

Leung K.C.M., McMillan A.S., Wong M.C.M., Leung W.K., Mok T.M.Y. and Lau C.S., The efficacy of cevimeline hydrochloride in the treatment of xerostomia in Sjögren's syndrome in southern Chinese patients: a randomised double-blind, placebo-controlled crossover study, Clinical Rheumatology. 2008, 27: 429-436.

 

Leung W.K., Keeping abreast with the latest clinical knowledge to better service our clients, Hong Kong Dental Journal. 2007, 4: 79.

 

Leung W.K., Siu S.C., Chu F.C.S., Wong K.W., Jin L.J., Sham A.S.K., Tsang P.C.S. and Samaranayake L.P., Oral health status of low-income, middle-aged to elderly Hong Kong Chinese with type 2 diabetes mellitus , Oral Health & Preventive Dentistry. 2008, 6: 105-118.

 

Leung W.K., What about periodontal health?, Hong Kong Dental Journal. 2008, 5: 9.

 

Lo E.C.M., Rong W.S., Siu S.C. and Leung W.K., Effects of Dental Care on Glycaemic Control in Type 2 Diabetes, The Chinese Journal of Dental Research. 2008, 11: 30-35.

 

Ng S.K.S. and Leung W.K., A community study of periodontal attachment loss in smokers, Journal of Dental Research. 2007, 86 (Spec Iss B): IO-11.

 

Ren L., Jin L.J. and Leung W.K., The in vivo expression patterns of IL-1b and IL-10 in chronic periodontitis, Chinese Journal of Stomatological Research. 2007, 1: 21-24.

 

Tsang P.C.S., Chu F.C.S., Leung W.K., Jin L.J., Samaranayake L.P. and Siu S.C., Phospholipase, proteinase and haemolytic activities of Candida albicans isolated from oral cavities of patients with type 2 diabetes mellitus, Journal of Medical Microbiology. 2007, 56: 1393-1398.

 

Wong R.M.S., Ng S.K.S., Corbet E.F. and Leung W.K., Oral health-related quality of life changes upon non-surgical periodontal therapy, Journal of Dental Research. 2007, 86 (Spec Iss B): IP-139.

 

Researcher : Li Q

List of Research Outputs

 

Li Q. and Rabie A.B.M., A new approach to control condylar growth by regulating angiogenesis, Archive of Oral Biology. 2007, 52: 1009-1017.

 

Researcher : Li TKL

List of Research Outputs

 

Chau C.M., Li T.K.L. and Mok W.H., 3D models showing relationship between horizontally impacted mandibular third molars and inferior dental canals using computed tomographic images, In: Balaji SM, Indian Journal of Maxillofacial & Oral Surgery. India, The Association of Oral and Maxillofacial Surgeons of, 2007, 6: 17-21.

 

Jayasinghe R.D. and Li T.K.L., Three-rooted first permanent mandibular molars in a Hong Kong Chinese population: a computed tomographic study, Hong Kong Dental Journal. 2007, 4(2): 90-93.

 

Researcher : Liang BMH

List of Research Outputs

 

Chai J.Y.C., Chu F.C.S., Chow T.W. and Liang B.M.H., Chemical solubility and flexural strength of zirconia-based ceramics., International Journal of Prosthodontics . 2007, 20: 587-595.

 

Researcher : Lin HC

List of Research Outputs

 

Wong A.H.H., Lo E.C.M., Chu C.H. and Lin H.C., Two minimally invasive treatments for decayed primary molars - 24-month results, Journal of Dental Research. 2007, 86 (Spec Iss B): IP-013.

 

Researcher : Ling JYK

List of Research Outputs

 

Ling J.Y.K. and Wong R.W.K., Incisal Morphology of Southern Chinese, The Open Anthropology Journal 2008. 2008, 1: 19-25.

 

Researcher : Lo ECM

Project Title:

A randomized clinical trial of two innovative methods in treating tooth decay in young children

Investigator(s):

Lo ECM, Chu CH

Department:

Dental Faculty

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

01/2005

 

Abstract:

To describe longitudinally the clinical outcomes of placing atraumatic restorative treatment (ART) restorations in decayed primary molars in young children; to describe longitudinally the clinical outcomes of treating decayed primary molars with annual topical applications of silver diamine fluoride (SDF) solution in young children; to compare the effectiveness of placing ART restorations with that of SDF solution applications on arresting the progression of dental caries in young children.

 

Project Title:

A comparative study on the cost-effectiveness of four methods in preventing fissure caries in permanent teeth

Investigator(s):

Lo ECM, Chu CH

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

01/2007

 

Abstract:

The aim of this proposed study is to investigate the cost-effectiveness of four methods in preventing fissure caries in permanent teeth in primary school children in China. The four caries prevention methods are: resin fissure sealant, atraumatic restorative treatment (ART) sealant, sodium fluoride varnish, and silver diamine fluoride (SDF) solution. The specific study objectives are: 1. to describe longitudinally the clinical outcomes of using the above four methods to prevent dental caries in the pits and fissures of permanent first molars in school children, 2. to describe the cost of using the above four methods to prevent dental caries in an outreaching dental care programme in China, and 3. to compare the cost-effectiveness of the above four caries prevention methods.

 

List of Research Outputs

 

Chu C.H. and Lo E.C.M., Dental caries prevention and treatment for preschool children in China, Chinese Journal of Dental Research. 2007, 10 (Suppl.): 54-60.

 

Chu C.H. and Lo E.C.M., Micro-hardness of dentine after silver diamine fluoride application, International Journal of Pediatric Dentistry . 2007, 17 Suppl 1: OS084.

 

Chu C.H. and Lo E.C.M., Micro-hardness of dentine in primary teeth after topical fluoride applications, Journal of Dentistry. 2008, 36: 387-391.

 

Chu C.H. and Lo E.C.M., Oral health of school age children in Kampong Thum Cambodia, Journal of Dental Research. 2007, 86 (Spec Iss B): IO-70.

 

Chu C.H., Wong A.W.Y., Lo E.C.M. and Courtel F., Oral health status and behaviours of children in rural districts of Cambodia, International Dental Journal. 2008, 58: 15-22.

 

Chu C.H. and Lo E.C.M., Outstanding poster presentation in the Inaugural Conjoint Dental Scientific Meeting 2008 The University of Hong Kong and Wuhan University , Faculty of Dentistry, The University of Hong Kong and School of Stomatology, Wuhan University . 2008.

 

Lee C.K., King N.M., Lo E.C.M. and Cho S.Y., Management of supplemental permanent maxillary lateral incisors in association with talon cusp on the primary predecessors: A report of 3 cases, Journal of Dentistry for Children. 2008, 75: 59-63.

 

Lo E.C.M., Wong A.H.H. and McGrath C.P.J., A randomized controlled trial of home tooth-whitening products, American Journal of Dentistry. 2007, 20: 315-318.

 

Lo E.C.M., Loo E.K.Y. and Lee C.K., Dental caries situation of Hong Kong kindergarten children, Journal of Dental Research. 2007, 86 (Spec Iss B): IP-072.

 

Lo E.C.M., Editorial board member, Journal of Dental Research. 2008.

 

Lo E.C.M., Rong W.S., Siu S.C. and Leung W.K., Effects of Dental Care on Glycaemic Control in Type 2 Diabetes, The Chinese Journal of Dental Research. 2008, 11: 30-35.

 

Lo E.C.M., Lui K.C., Chan S.M., Chan W.L., Ching S.T., Fok W.C., Law W.M., Lee Y.M., Leung C.S.Y., Wong L.O. and Wong N., Oral health care service for elders in a care and attention home, Community Health Project Report Series. Faculty of Dentistry, The University of Hong Kong, 2008, 153: 1-40.

 

Lo E.C.M., Oral health in Hong Kong over the past 25 years and the role of local graduates, Second International Conference on Evidence-based Advanced Dentistry. 2007.

 

Lo E.C.M., Outstanding research student superviaor award 2006-2007, University of Hong Kong. 2008.

 

Lo E.C.M., Holmgren C.J., Hu D. and van Palenstein Helderman W., Six-year follow up of atraumatic restorative treatment restorations placed in Chinese school children, Community Dentistry and Oral Epidemiology. 2007, 35: 387-392.

 

McGrath C.P.J., Pang H.H., Lo E.C.M., King N.M., Hagg E.U.O. and Samman N., Translation and evaluation of a Chinese version of the child oral health-related quality of life measure., Int J Paediatr Dent. 2008, 18: 267-274.

 

Wong A.H.H., Lo E.C.M., Chu C.H. and Lin H.C., Two minimally invasive treatments for decayed primary molars - 24-month results, Journal of Dental Research. 2007, 86 (Spec Iss B): IP-013.

 

Wong A.H.H., Lo E.C.M., Chu C.H. and Lin H.C., Two minimally invasive treatments for decayed primary molars 18 month results, International Journal of Pediatric Dentistry. 2007, 17 Suppl 1: PO119.

 

You D.S.H., Chu C.H. and Lo E.C.M., Best presentation in the subject area "Cariology research" in the 21st Annual Scientific Meeting, Southeast Asian Division of International Association for Dental Research . 2007.

 

You D.S.H., Chu C.H. and Lo E.C.M., Precision of clinical diagnosis of fissure caries by different methods, Journal of Dental Research. 2007, 86 (Spec Iss B): IP-027.

 

Researcher : Lo J

Project Title:

3 dimensional hard and soft tissue assessment of maxillofacial deformity in Hong Kong Chinese population

Investigator(s):

Lo J, Wong MCM

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

12/2005

 

Abstract:

Objectives 1. To acquire the 3-D facial norm value in Hong Kong Chinese Population. 2. To develop a 3-D soft & hard tissue assessment scheme for patient presented with maxillofacial deformity. Backgrounds Facial profile could be regarded as one of the most important concern of every single person. Maxillofacial deformities, which would distort upper & lower jaws’ relationship and facial profile, are reported to affect approximately 20% of the world’s population. Tremendous advances in the treatment of these deformities have been made since 1970s. Orthognathic surgery, specially designed for the correction of these deformities, is currently one of the most common practices in the field of oral & maxillofacial surgery. The success of the orthognathic surgery depends not only on the surgical techniques, but also upon an accurate pre-surgical plan. The traditional approach to a maxillofacial deformity involves clinical examination, plain X-rays, dental model surgery and videoimaging surgical simulation. Among them, the videoimaging surgical simulation could be regarded as one of the most important component. Apart from assisting surgeon to make an accurate treatment plan, this technique also tremendously helps the communication between surgeons and patients. In a study, 6-month after surgery in a non-imaged population, only 45% of patients reported satisfaction with the aesthetic outcome of their orthognathic surgery, whereas 89% of patients reported satisfaction with their aesthetic outcome after using videoimaging simulation in the same period. Outline of problem Despite the continuous evolution of technology, the traditional approach had several limitations: (1) The dental model surgery involves only correction of the occlusion only, while the correction of some additional skeletal deformity, including chin, mandibular border, gonial angle, paranasal, malar, and zygoma region, would rely mainly on intra-operative judgement. (2) Current videoimaging softwares share the similar limitation: the prediction is only limited in lateral profile only. Prediction of the frontal profile, based on the plain radiographs, is nearly impossible due to overlapping of the hard and soft tissue landmarks. Benefits of videoimaging technique are hence limited to cases presented with deformity in lateral profile / sagittal plane; while patients presented with problem in frontal / coronal plane could not gain any benefits from this technique. As a result, correction of any deformity in frontal plane, i.e. facial asymmetry, is depending solely on the model surgery and intra-operative judgment; and those patients are in lack any visualization of the change after operation. With the rapid increasing in quantity and quality, the worldwide Oral Health Care System becomes much more sophisticated. Patients’ demand on good quality treatment is increasing as well. The previous standard established since late 1980s, could no longer meet today patient’s expectation. Due to the complexity of the facial skeleton, current trend in surgical planning is moving from 2-dimension to 3-dimension. Past research in this field The use of 3D cephalometric analysis had been reported since 1996. Thereafter, a number of reports had been published. All 3D cephalometric analysis is based on measurement on CT scan. It is noteworthy that all the reports are consistent with the advantages in direct visualization of the hard tissue problem especially in patients presented with asymmetry. Regarding the soft tissue analysis, 3D soft tissue capture technique had been developed since 1996. The techniques included: morphanalysis, laser scanning, 3D CT, stereolithography, 3D ultrasonography, 3D facial morphometry, digigraph imaging, Moire topography, and contour photography. Recently, the use of stereophotogrammetry had gained popularity due to its fast capture speed as well as the photo-realistic quality. The application of stereophotogrammetry in studying asymmetry had been widely studied. Nevertheless, there was no literature regarding the combination of 3D hard and soft tissue capture, analysis and surgical planning. Situation in Hong Kong & Chinese Population The discipline of Oral and Maxillofacial Surgery, the University of Hong Kong, is the largest maxillofacial center in Hong Kong, and one of the most advanced maxillofacial center in Asia and the world. From 1990 to 2004, there were about 4530 patients received major operations from our discipline. Among them, 1455 patients (32.12%) received orthognathic surgeries for correction of their maxillofacial deformity. Majority of patients (60%) were presented with Class III deformity, while approximately 23 % patients were presented with deformity in frontal / coronal plane. Currently, assessment of the changes of facial skeleton could be achieved through plain radiograph and lateral portrait using our CASSOS system (Softenable, Hong Kong). Since every single patient would like to know what he or she is going to look like after surgery, 3D facial analysis, planning and surgical simulation system of patients with maxillofacial deformity seems to be necessary to solve the shortcoming of the traditional 2D facial analysis. Specific Aims 1. To acquire the 3-D facial value in Hong Kong Chinese Population. All the current soft tissue change indices available are based on studies of single jaw surgery in Caucasian using lateral portrait only since early 1990s (Bell et al, 1992). Nowadays, bimaxillary osteotomies are more common. And relative to Caucasian, Chinese population have obvious difference in both hard and soft tissue profile, namely, the mandibular length, cranial base, and gonial angle, etc (Ngan et al. 1997). It is noteworthy that current available cephalometric and soft tissue norm data available for Chinese / Asian are based on cephalometric and lateral portrait only. To develop a new application to produce a realistic surgical simulation and prediction, a 3D norm hard and soft tissue data seems necessary. Result from this study could also be employed for comparison to the previous golden standard from 1994 (Farkas et al., 1994). 2. To develop a 3-D soft & hard tissue assessment and planning scheme for maxillofacial deformity Based on the norm data obtained from the specific aim (1), a further insight in the variation of patients with maxillofacial deformity from normal subjects could be obtained. By measurement of the postoperative 3D data, an estimation of the 3D soft tissue – hard tissue movement ratio of Chinese population could be established.

 

List of Research Outputs

 

Cheung L.K., Chua H.D.P., Lo J. and Luk W.K., Vector guidance splint for internal maxillary distraction, Journal of Oral and Maxillofacial Surgery. 2007, 65 (9): p. 1852-1856.

 

Jayaratne Y.S.N., Lo J. and Cheung L.K., The use of 3-D photography for surgical planning in hemifacial microsomia, Second International Conference on Evidence-based Advanced Dentistry, Conjoint Congress 16-19 November 2007, Hong Kong. 2007, p. 60 (# 021).

 

Jayaratne Y.S.N., Lo J., Zwahlen R.A. and Cheung L.K., Virtual craniofacial model fabrication for surgical planning, Inaugural Conjoint Dental Scientific Meeting, The University of Hong Kong and Wuhan University. 10-11 May, 2008, China. 2008, p. 44.

 

Lo J., Cheung L.K. and Jayaratne Y.S.N., 3-dimensional surgical planning of facial reconstruction in hemifacial microsomia , 89th Annual Meeting, American Oral & Maxillofacial Surgeons. 2007.

 

Lo J. and Cheung L.K., Distraction for the treatment of TMJ ankylosis, AO Course on Endoscopic Fixation and Advances in Distraction Osteogenesis . 2007.

 

Lo J., Oral & Maxillofacial Surgery: Scope and practice in Hong Kong, Association of Hong Kong Operating Room Nurses. 2008.

 

WEY M.C., TAN M.N., LIM Y.C., Cheung L.K. and Lo J., Spectrum and surgical modalities of dentofacial deformities in Universiti Malaya and University of Hong Kong, Second International Conference on Evidence-based Advanced Dentistry, Conjoint Congress 16-19 November 2007, Hong Kong. 2007, p. 40 (P1).

 

Researcher : Low DCY

List of Research Outputs

 

Low D.C.Y., Removal of root filling materials with ProTaper® retreatment instruments., Dentsply Update. 2007, 21: 7-8.

 

Researcher : Lu Q

List of Research Outputs

 

Jin L.J., Lu Q., Samaranayake L.P. and Darveau R., P. gingivalis Lipopolysaccharide with different structures differentially modulates innate responses, Journal of Dental Research. 2007, 86 (Spec Iss B): IO-14.

 

Lu Q., Jin L.J., Samaranayake L.P. and Darveau R.P., Outstanding Oral Presentation Award (Primary supervisor for Dr. Q. Lu, a postdoctorial fellow), 2nd International Conference on Evidence-based Advanced Dentistry, Hong Kong, China, 16-19 November 2007. 2007.

 

Lu Q., Samaranayake L.P., Darveau R.P. and Jin L.J., Outstanding Poster Presentation Award (Primary supervisor for Dr. Q. Lu, a postdoctorial fellow), Inaugural Conjoint Dental Scientific Meeting - The University of Hong Kong and Wuhan University, China, 10-11 May, 2008. 2008.

 

Lu Q., Jin L.J., Samaranayake L.P. and Darveau R., P. gingivalis lipopolysaccharides upregulate protease-activated receptor expression in gingival epithelium, Journal of Dental Research. 2007, 86 (Spec Iss B): IP-130.

 

Researcher : Lui KC

List of Research Outputs

 

Lo E.C.M., Lui K.C., Chan S.M., Chan W.L., Ching S.T., Fok W.C., Law W.M., Lee Y.M., Leung C.S.Y., Wong L.O. and Wong N., Oral health care service for elders in a care and attention home, Community Health Project Report Series. Faculty of Dentistry, The University of Hong Kong, 2008, 153: 1-40.

 

Wong M.C.M., Lui K.C., Chan M.H., Cheng G.W.K., Cheung A.W.T., Cheung G.J.K., Fung P.L., Fung S.L., Lam Y.H., Mui N.H.T., Wong K.L. and Wong K.Y., Oral health care for inmates of rehabilitation centres in Hong Kong, Community Health Project Report Series. Faculty of Dentistry, The University of Hong Kong, 2008, 152: 1-50.

 

Researcher : Luk WK

List of Research Outputs

 

Cheung L.K., Chua H.D.P., Lo J. and Luk W.K., Vector guidance splint for internal maxillary distraction, Journal of Oral and Maxillofacial Surgery. 2007, 65 (9): p. 1852-1856.

 

Luk W.K., Pow E.H.N. and Dias A.P.L.H., A Qualtiy Assessment of the Casting Process on Magnetic Keepers, Journal of Prosthodontics. 2007, 16: 249-254.

 

Luk W.K., Implants: Laboratory Aspects, Second International Conference on Evidence-based Advanced Dentistry. 2007.

 

Luk W.K., Laboratory aspects on the supra-structure, Second International Conference on Evidence-based Advanced Dentistry. 2007.

 

Luk W.K., Technical Aspects Of Dental Ceramic Systems., Oral Health & Science Seminars, Faculty Of Dentistry, The University Of Hong Kong.. 2008.

 

Pow E.H.N., Chan K.H.C., Luk W.K., Dias A.P.L.H. and McMillan A.S., Effect of laboratory procedures on casting magnetic keepers with gold alloy, Inaugural Conjoint Dental Scientific Meeting of the University of Hong Kong and Wuhan University. 2008.

 

Researcher : Luo Y

Project Title:

Clinical efficacy of two topical fluoride agents for treatment of dentinal hypersensitivity

Investigator(s):

Luo Y, Lo ECM

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

01/2006

 

Abstract:

Dentinal hypersensitivity, also known as tooth sensitivity, can be described as a short sharp pain triggered by a stimulus such as cold or hot foods/beverages, sweet, sour, or acidic foods and even brushing and flossing. It may occur when the enamel is worn away or more frequently, when the gums recede and the cementum on root surface is worn away leaving the underlying dentine exposed. Both incorrect oral hygiene techniques by patients and by instrumentation of the root surface by dental professionals in the management of periodontal diseases can lead to the symptoms of dentine hypersensitivity. A variety of agents have been suggested for treatment of dentine hypersensitivity, including the use of potassium nitrate, strontium chloride, sodium fluoride, silver nitrate and calcium hydroxide. These agents generally work by blocking the dentinal tubules resulting in diminishing the movement of fluid in the tubules e.g., the hydrodynamic theory or the primary mechanism for dentine hypersensitivity. However, evidence from well-conducted clinical trials to support the claimed effectiveness of these agents is scanty. The purpose of this study is to evaluate the effectiveness of two topical fluoride agents, a 38% silver diammine fluoride solution and a 5% sodium fluoride varnish, in reducing dentinal hypersensitivity after non-surgical periodontal treatment. The objectives of the study are: 1. to describe the effectiveness of a single application of a 38% silver diammine fluoride solution in reducing dentinal hypersensitivity in teeth that are sensitive to external stimuli after non-surgical periodontal treatment; 2. to describe the effectiveness of a single application of a 5% sodium fluoride varnish in reducing dentinal hypersensitivity in teeth that are sensitive to external stimuli after non-surgical periodontal treatment; and 3. to compare the effectiveness of the above two topical fluoride agents in reducing dentinal hypersensitivity in teeth that are sensitive to external stimuli after non-surgical periodontal treatment.

 

List of Research Outputs

 

Researcher : Ma L

List of Research Outputs

 

Ma L., Zheng L. and Cheung L.K., Changes in blood supply and bone regeneration induced by nicotine during distraction osteogenesis, Bone. 2008, 42, S1: p. S60.

 

Ma L., Zheng L. and Cheung L.K., Influence of Nicotine on the expression of angiogenic factors in distraction osteogenesis, 1st International Bone and Dental Technology Symposium, November 2007, Bangkok, Thailand. 2007, p. 72.

 

Ma L., Zheng L. and Cheung L.K., The impact of Nicotine on blood perfusion and bone regeneration in distraction osteogenesis, Inaugural Conjoint Dental Scientific Meeting, The University of Hong Kong and Wuhan University. 10-11 May, 2008, China. 2008, p. 17.

 

Ma L., Zheng L. and Cheung L.K., The impact of nicotine on bone regeneration in distraction osteogenesis, Second International Conference on Evidence-based Advanced Dentistry, Conjoint Congress 16 - 19 November 2007, Hong Kong. 2007, p. 35 (# 013).

 

Zheng L., Ma L. and Cheung L.K., Changes in blood perfusion and bone healing induced by nicotine during distraction osteogenesis. , Bone. 2008, 43: p. 355-361.

 

Zheng L., Cheung L.K., Ma L. and Wong M.C.M., High-rhythm automatic driver for bone traction: an experimental study in rabbits. , Int J Oral Maxillofac Surg . 2008, 37: p 736-740.

 

Zheng L., Ma L. and Cheung L.K., Influence of continuous traction on the gene expression of BMP-2 and TGF-β in distraction osteogenesis, 1st International Bone and Dental Technology Symposium, November 2007, Bangkok, Thailand. 2007, p. 63.

 

Zheng L., Ma L. and Cheung L.K., Influence of distraction frequency on angiogenesis in rabbit mandibular lengthening, Inaugural Conjoint Dental Scientific Meeting, The University of Hong Kong and Wuhan University. 10-11 May, 2008, China. 2008, p. 15.

 

Zheng L., Ma L. and Cheung L.K., Influence of frequency of mechanical traction on gene expression and angiogenesis in rabbit mandibular lengthening, Bone. 2008, 42, S1: p. S66 - S67.

 

Zheng L., Ma L. and Cheung L.K., Shall we rewrite the distraction protocol for continuous distraction osteogenesis?, Second International Conference on Evidence-based Advanced Dentistry, Conjoint Congress 16-19 November 2007, Hong Kong. 2007, p. 35 (# 012).

 

Researcher : McGrath CPJ

Project Title:

'Bucked teeth' (severe incisor overjet), orthodontic corrective treatment and the life quality of children in China: a multi-centre cohort study

Investigator(s):

McGrath CPJ, Hagg EUO

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2003

 

Abstract:

To assess the impact of severe incisor overjet on the life quality of children in China; to measure changes in the impact of oral health on the quality of life of children who undergo corrective orthodontic treatment of severe incisor overjet; to assess the correlation between changes in the magnitude of oral health related quality of life following orthodontic treatment and the improvements in alignment of teeth observed clinically.

 

List of Research Outputs

 

Bridges S.M., McGrath C.P.J. and Yiu C.K.Y., When official policies meet site-based realities: Diversity and clinical dental education in Hong Kong, Eighth International Conference on Diversity in Organisations, Communities and Nations. 2008.

 

Bridges S.M., McGrath C.P.J. and Yiu C.K.Y., Working the ‘place’ of languages in clinical dental education, 9th International Conference of the Association for Language Awareness. 2008.

 

Chong M.M., Chow T.F., Huang K.Y., Lam H.H., Lo H.Y., Tse C.M., Wong S.Y., Yu K.Y. and McGrath C.P.J., Pregnancy and oral health in Hong Kong, Journal of Dental Research. 2007, 86 (Spec Iss B): IO-72.

 

Corbet E.F., Akinwade J., Duggal R., Gebreegziabher G., Hirvikangas H., Hysi D., Katrova L., Karaharju-Suvanto T., McGrath C.P.J., Ono K., Radnai M., Schwarz E., Scott J., Sixou J.L., Soboleva U., Uoshima K., Yaneva-Ribagina K. and Fox C., Staff recruitment, development and global mobility, European Journal of Dental Education. 2008, 12 (Suppl. 1): 149-160.

 

Hagg E.U.O., McGrath C.P.J. and Zhang M., Quality of life and orthodontic treatment need related to occlusal indices, The Hong Kong Medical Diary. 2007, 12: 8-11.

 

Lau A.W.H., Wong M.C.M., Lam K.F. and McGrath C.P.J., Evaluation of child perceptions questionnaire (CPQ11-14) using structural equation modeling, Journal of Dental Research. 2007, 86 (Spec Iss B): IO-21.

 

Lee C.K., McGrath C.P.J., Wong R.W.K. and Rabie A.B.M., Patient's perceptions regarding microimplant as anchorage in orthodontics, Angle Orthodontist. 2008, 78: 228-233.

 

Lee S., McGrath C.P.J. and Samman N., Impact of orthognathic surgery on quality of life, J Oral Maxillofac Surg. 2008, 66: p. 1194-1199.

 

Lee T.C.K., Rabie A.B.M., Wong R.W.K. and McGrath C.P.J., Patients’ Perceptions Regarding Microimplant as Anchorage in Orthodontics, Outstanding Poster Award. Second International Conference on Evidence-based Advanced Dentistry, Conjoint Congress 2007. Hong Kong, China, 16 – 19 November, 2007. 2007.

 

Lo E.C.M., Wong A.H.H. and McGrath C.P.J., A randomized controlled trial of home tooth-whitening products, American Journal of Dentistry. 2007, 20: 315-318.

 

McGrath C.P.J., Chow L.P.S., Fong S.Y., Fong S.T., Liang B.M.H., Luk C.H., Tsang F.C., Wong H., Wong C.B. and Yip S.L., Improving knowledge of dental first aid through a Red Cross health promotion programme, Community Health Project Report Series. Faculty of Dentistry, The University of Hong Kong, 2008, 156: 1-32.

 

McGrath C.P.J., Chan S.Y., Chan K.T.H., Fu L.W., Fung K.C., Hon M.K., Lai C.L., Lam S.N., Wan P.C., Wong C.M. and Yung K.Y., Outreach dental services in the 'City of Sadness', Community Health Project Report Series. Faculty of Dentistry, The University of Hong Kong, 2008, 157: 1-49.

 

McGrath C.P.J., Pang H.H., Lo E.C.M., King N.M., Hagg E.U.O. and Samman N., Translation and evaluation of a Chinese version of the child oral health-related quality of life measure., Int J Paediatr Dent. 2008, 18: 267-274.

 

Mok C.W., Zhou L., McGrath C.P.J., Hagg E.U.O. and Bendeus S.A.M., Digital images as an alternative to orthodontic casts in asessessing malocclusion and orthodontic treatment need , Acta Odontol. 2007, 65: 362-268.

 

Wong M.C.M., Lau A.W.H., Lam K.F. and McGrath C.P.J., Construct validity of the short forms child perceptions questionnaire (CPQ11-14), Journal of Dental Research. 2007, 86 (Spec Iss B): IO-22.

 

Wu A.K.Y., McGrath C.P.J., Wong R.W.K. and Rabie A.B.M., A comparison of pain experienced by patients treated with labial & lingual orthodontic appliances, The 19th Convocation of the Royal Australasian College of Dental Surgeons, Conjoint with The College of Dental Surgeons of Hong Kong. Hong Kong Convention & Exhibition Centre, Hong Kong, 30 May – 2 June, 2008.

 

Zhang M., McGrath C.P.J. and Hagg E.U.O., Changes in oral health-related quality of life during fixed orthodontic appliance therapy, American Journal of Orthodontics and Dentofacial Orthopedics. 2008, 133: 25-29.

 

Zhou L., Mok C.W., Hagg E.U.O., McGrath C.P.J., Bendeus S.A.M. and Wu J.Y.C., Anteroposterior Dental Arch and Jaw-Base Relationships in a Population Sample, Angle Orthodontist. 2008, 78: 1023-1029.

 

Zhu H., McGrath C.P.J., McMillan A.S. and Li L.S.W., Can caregivers be used in assessing oral health-related quality of life among patients hospitalized for acute medical conditions?, Community Dentistry and Oral Epidemiology. 2008, 36: 27-33.

 

Zhu H., McMillan A.S., McGrath C.P.J., Li L.S.W. and Samaranayake L.P., Oral carriage of yeasts and coliforms in stroke sufferers: a prospective longitudinal study, Oral Diseases. 2008, 14(1): 60-66.

 

Researcher : McMillan AS

Project Title:

Orofacial Pain and its Functional and Psychosocial Impact

Investigator(s):

McMillan AS, Wong MCM, Lam CLK, Luo Y

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2005

 

Abstract:

This is a cross-disciplinary study involving the Faculties of Dentistry and Medicine that is directly related to the major research theme of Healthy Ageing.Hypotheses:o A substantial number of community-dwelling adults in Hong Kong suffer from orofacial pain (OFP) and the majority of them do not seek professional help for their condition o OFP is an under-treated condition that causes significant disability and has a serious adverse effects on people's well-being and quality of life.Purpose: To investigate a) the prevalence of OFP and its diagnostic sub-groups in community dwelling adult people in Hong Kong, b) the adverse impact of OFP on functional and psychosocial wellbeing, and c) barriers to treatment seeking for OFP symptoms.Objectives:o To determine the frequency, severity and pattern of OFP according to diagnostic sub-groups using validated patient-centred measures and clinical assessmento To describe the treatment seeking behaviour associated with OFP and factors associated with such behaviouro To assess the impact of OFP on health-related QoL using generic and condition specific health status measureso To correlate patient descriptions of OFP with clinical diagnosesPain is closely associated with poor health. The negative effect of pain on health outcomes such as function and quality of life (QoL) among patient populations is well documented (Ahmedzai, 1995). However, little is known about the impact of pain on subjective health and well-being in community dwelling populations (Reyes-Gibby et al, 2002).Although pain is a common symptom of dental and oral disease and can have a significant impact, there is a shortage of systematic data on the prevalence, severity and consequences of orofacial pain (OFP) in general, non-clinical populations (Nikias, 1985). In a community based study in Toronto, Locker & Grushka (1987) noted that 53% of participants had experienced some pain or discomfort in the orofacial region in the previous four weeks. The majority of pain reports were tooth or gum related whereas pain in the jaws, face and oral mucosa were less common.Epidemiological studies in the USA, Canada and the United Kingdom have shown that the prevalence of oro-facial pain symptoms in adult populations ranges from 14 to 40% (Lipton et al, 1993; Locker & Grushka, 1987; Macfarlane et al 2002). Gender and age-related differences in oro-facial pain prevalence have also been noted with women and younger adults at apparently greater risk of pain symptoms, whereas older people are more likely to suffer more severe pain (Macfarlane et al, 2002; Von Korff et al, 1988). Pain may have considerable impact on people's ability to perform effectively at work, home and school. Nonetheless, not everyone seeks professional help for pain with some symptoms being ignored while others may prompt action (Macfarlane et al, 2003). It is, therefore, important to discern factors that may distinguish individuals who seek professional care from those who do not. In a population-based study of OFP in the UK, Macfarlane et al (2003) noted that less than half of their study population with OFP sought professional advice. The majority of factors associated with seeking treatment appeared to be various characteristics of pain although the time course of these factors was unclear. Locker & Grushka (1987) observed that while more than 50% of their OFP study group described pain severity as moderately severe or severe, only 40 % of those reporting pain sought advice from a doctor of dentist. Ethnic differences in the perception of and means of managing pain account, at least in part, for observed differences in treatment seeking behaviour for orofacial pain conditions (Hastie et al, 2005). Socioeconomic status is also an important factor related to treatment seeking with oral disease generally more common among those least able to access health care and leads to needless pain and suffering (Riley et al, 2005).There is presently very little information on the prevalence and impact of oro-facial pain in Southern Chinese people in Hong Kong. Most oro-facial pain prevalence studies have focused on predominantly Caucasian populations. However, a recent study in Korean elders indicated that the prevalence was higher in this ethnic group and significant disability was associated with the condition (Chung et al, 2004). In a previous population-based survey, we have shown that self-reported pain symptoms associated with temporomandibular disorders are relatively common in the Hong Kong Chinese population (Pow et al, 2001). However, the characteristics of the pain differed from other ethnic groups, no gender bias in pain symptoms was observed and treatment seeking was much lower than in Caucasian counterparts. One of the problems associated with the available epidemiological data on prevalence of OFP is that it has been collected solely by means of questionnaires with patient self-reports not being confirmed by clinical assessment (Macfarlane et al, 2004). There is, therefore, the risk that patient described pain symptoms are misinterpreted and pain symptoms due to multiple conditions may go unrecognized. Definitive diagnoses can only be obtained by clinical assessment.References:Ahmedzai S. Recent clinical trials of pain control: impact on quality of life. Eur J Cancer 1995;31A(Suppl):S2-7Chung JW, Kim JH, Kim HD, Kho HS, Kim YK, Chung SC. Chronic orofacial pain among Korean elders: prevalence, and impact using the graded chronic pain scale. Pain 2004;112:164-170Hastie BA, Riley III JL, Fillingim RB. Ethnic differences and responses to pain in healthy young adults. Pain Medicine 2005;6:61-71Lipton JA, Ship JA, Larach-Robinson D. Estimated prevalence and distribution of reported orofacial pain in the United Sates. J Am Dent Assoc 1993;124:115-121Locker D, Grushka M. Prevalence of oral and facial pain and discomfort: preliminary results from a mail survey. Community Dent Oral Epidemiol 1987;15:169-172Macfarlane TV, Blinkhorn AS, Davies RM, Kincey J, Worthington HV. Factors associated with health care seeking behaviour for orofacial pain in the general population. Community Dent Health 2003;20:20-26Macfarlane TV, Blinkhorn AS, Craven R et al. Can one predict the likely specific orofacial pain syndrome from a self-completed questionnaire? Pain 2004;111:270-277Nikias M. Oral disease and the quality of life. Am J Public Health 1985;75:11-12Reyes-Gibby C, Aday L, Cleeland C. Impact of pain on self-related health in community-dwelling older adults. Pain 2002;95:75-82Riley III JL, Gilbert GH. Orofacial pain symptoms: an interaction between age and sex. Pain 2001;90:245-256Von Korff M, Ormel J, Keefe FJ, Dworkin SF. Grading the severity of chronic pain complaints. Pain 1988;32:173-183

 

Project Title:

Predictors of outcome of orofacial pain: A community-based longitudinal study

Investigator(s):

McMillan AS, Wong MCM, Lam CLK, Luo Y, Zheng J

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2006

 

Abstract:

This is a cross-disciplinary study involving the Faculties of Dentistry and Medicine that is directly related to the major research theme of Healthy Ageing.Purpose: To investigate a) the pain characteristics in community-dwelling adult Hong Kong Chinese people with OFP, b) to follow-up OFP sufferers over a 6-month period and identify presenting factors and behaviours that predict poor outcome. Null hypotheses:- Orofacial pain does not tend to persist - There are no factors that can predict the persistence of OFPObjectives:o To describe the outcome of OFP after a period of 6-monthso To identify baseline factors that predict poor outcome in adults with OFPOrofacial pain (OFP) may be defined as pain related to the face and/or mouth and involves both hard and soft tissues in these anatomical regions. Epidemiological studies in the USA, Canada and the United Kingdom have shown that the prevalence of OFP symptoms in adult populations ranges from 14 to 40%.1-3 In a population-based survey of OFP symptoms in adult Chinese people in Hong Kong, the one-month period prevalence of OFP (42%) was found to be consistent with estimates in western countries.4 Pain is closely associated with poor health and may considerably impair people's ability to perform daily living activities. Despite this, not all pain sufferers seek professional help with some symptoms being ignored whilst others prompt attention. (2,3,5,6). In studies involving western cohorts 44-46% with OFP sought professional help (2,5,6). However, only 20% of Hong Kong Chinese adults with OFP symptoms sought professional treatment.4 Thus, it is important to explore the factors and barriers relating to professional treatment seeking behaviour in order to understand the disparity between Chinese adults and their western counterparts. MacFarlane et al5 noted that pain characteristics appeared to prompt treatment seeking although the time course of these factors was unclear. The decision to seek treatment may be related to the consequences of the OFP as experienced by the individual and also affected by culturally-mediated responses to the pain experience and its consequences (7). A key characteristic of OFP is that it tends to persist (8). In a longitudinal study in the United Kingdom, over half those with OFP at baseline reported pain four years later (9). Persistent pain was associated with females, increasing age, psychological distress, widespread body pain and taking pain medication at baseline. In a Swedish cohort, the follow-up of 109 patients with OFP revealed that after 4 to 9 years only 27% had resolution of the pain, with pain medication usage at baseline a strong predictor of persistent OFP (10). The consequences of OFP have an impact on various aspects of daily life and include work loss, sleep disturbance, need for more rest, avoidance of social contacts, and difficulty eating and speaking (2,11). The magnitude of the impact appears to be related to the pain characteristics and socio-demographics of the respondents (2,3,11). Pain-related sleep disturbance is also a key determinant of seeking professional treatment (6). There is scant information available on the characteristics of OFP in southern Chinese people, its potential to persist and the functional and psychosocial impact. In a population-based survey of symptoms of temporomandibular disorders in Hong Kong Chinese people, jaw pain, restricted jaw opening and jaw clicking were the most common presenting symptoms and often associated with significant morbidity (12). In contradistinction to western studies, there were no gender-related differences in symptom reporting or treatment seeking (12). In a recent study of chronic OFP in elderly Koreans the prevalence appeared to be higher compared with Caucasian populations.13Adverse impacts were common with around 30% of those with joint pain, toothache and burning mouth symptoms having significant associated disability and impairment of daily living activities (13). The ideal approach to the investigation of OFP in the community is by interview using validated questionnaires and clinical assessment. However, most studies where patient-based and clinical data are available involve a bias sample of people seeking treatment. In epidemiological studies of OFP, the most common means of obtaining information is by questionnaire, by mail or telephone survey, without clinical examination of the participants. Even with contemporary questionnaire approaches, without clinical assessment, there is always the issue of data reliability. References 1. Lipton JA, Ship JA, Larach-Robinson D. Estimated prevalence and distribution of reported orofacial pain in the United States. J Am Dent Assoc 1993;124:115-21.2. Locker D, Grushka M. Prevalence of oral and facial pain and discomfort: preliminary results of a mail survey. Community Dent Oral Epidemiol 1987a;15:169-72.3. Macfarlane TV, Blinkhorn AS, Davies RM, Kincey J, Worthington HV (2002). Oro-facial pain in the community: prevalence and associated impact. Community Dent Oral Epidemiol 30(1):52-60.4. McMillan AS, Wong MCM, Zheng J, Lam CLK. Prevalence of orofacial pain and treatment seeking in Hong Kong Chinese. J Orofac Pain (in press) 5. Macfarlane TV, Blinkhorn AS, Davies RM, Kincey J, Worthington HV. Factors associated with health care seeking behaviour for orofacial pain in the general population. Community Dent Health 2003;20:20-26.6. Locker D. The symptom iceberg in dentistry. Treatment-seeking in relation to oral and facial pain. J Can Dent Assoc 1988:54:271-4.7. Hastie BA, Riley JL, Fillingim RB. Ethnic differences and responses to pain in healthy young adults. Pain Med 2005;6:61-71.8.Von Korff M, Ormel J, Keefe F, Dworkin S (1992). Grading the severity of chronic pain. Pain 50(2):133-149.9.Macfarlane TV, Blinkhorn AS, Davies RM, Kincey J, Worthington HV. Predictors of outcome for orofacial pain in the general population: a four-year follow-up study. 2004 J Dent Res ;83:712-7.10. Wolf E, Nilner M, Petersson A, Petersson K (2002). Long-term follow-up by means of a questionnaire of 109 patients with long-lasting orofacial pain. Swed Dent J. 26(3):125-34.11. Locker D, Grushka M. The impact of dental and facial pain. J Dent Res 1987;66:1414-7.12. Pow EHN, Leung KCM, McMillan AS. Prevalence of symptoms associated with temporomandibular disorders in Hong Kong Chinese. J Orofac Pain 2001;15:228-34.13. Chung JW, Kim JH, Kim HD, Kho HS, Kim YK, Chung SC. Chronic orofacial pain among Korean elders: prevalence, and impact using the graded chronic pain scale. Pain 2004;112:164-70.

 

List of Research Outputs

 

Lee L.T.K., Yeung R.W.K., Wong M.C.M. and McMillan A.S., Diagnostic sub-types, psychological distress and psychosocial dysfunction in southern Chinese people with temporomandibular disorders, Journal of Oral Rehabilitation. 2008, 35(3): 184-90.

 

Leung K.C.M., McMillan A.S., Cheung B.P.K. and Leung W.K., Sjögren's syndrome sufferers have increased oral yeast levels despite regular dental care, Oral Diseases. 2008, 14: 163-173.

 

Leung K.C.M., Leung W.K. and McMillan A.S., Supra-gingival microbiota in Sjögren's syndrome, Clinical Oral Investigations. 2007, 11: 415-423.

 

Leung K.C.M., McMillan A.S., Wong M.C.M., Leung W.K., Mok T.M.Y. and Lau C.S., The efficacy of cevimeline hydrochloride in the treatment of xerostomia in Sjögren's syndrome in southern Chinese patients: a randomised double-blind, placebo-controlled crossover study, Clinical Rheumatology. 2008, 27: 429-436.

 

Perera R.A.P.M., Tsang P.C.S., Li P., Lee M.P., Samaranayake L.P. and McMillan A.S., Oral Manifestations of ethnic Chinese HIV-infected adults on HAART, Inaugural Conjoint Dedntal Scientific Meeting. The University of Hong Kong and Wuhan University 2008.. 2008.

 

Pow E.H.N., Chan K.H.C., Luk W.K., Dias A.P.L.H. and McMillan A.S., Effect of laboratory procedures on casting magnetic keepers with gold alloy, Inaugural Conjoint Dental Scientific Meeting of the University of Hong Kong and Wuhan University. 2008.

 

Pow E.H.N., Botelho M.G., Chow T.W., Dias A.P.L.H., Dyson J.E., Leung K.C.M. and McMillan A.S., Student's manual to the BDS V Prosthodontic Clinical Skills and Technology Course in Oral Rehabilitation 2007-2008. Hong Kong, 2007, 1-76.

 

Pow E.H.N., Botelho M.G., Chow T.W., Dias A.P.L.H., Dyson J.E., Leung K.C.M. and McMillan A.S., Teacher's manual to the BDS V Prosthodontic Clinical Skills and Technology Course in Oral Rehabilitation 2007-2008. Hong Kong, 2007, 1-89.

 

Tsang P.C.S., Ng H. and McMillan A.S., Antifungal susceptibility of Candida albicans biofilms on titanium discs with different surface roughness, Clinical Oral Investigations. 2007, 11(4): 361-8.

 

Zhu H., McGrath C.P.J., McMillan A.S. and Li L.S.W., Can caregivers be used in assessing oral health-related quality of life among patients hospitalized for acute medical conditions?, Community Dentistry and Oral Epidemiology. 2008, 36: 27-33.

 

Zhu H., McMillan A.S., McGrath C.P.J., Li L.S.W. and Samaranayake L.P., Oral carriage of yeasts and coliforms in stroke sufferers: a prospective longitudinal study, Oral Diseases. 2008, 14(1): 60-66.

 

Researcher : Mcgrath CPJ

Project Title:

'Bucked teeth' (severe incisor overjet), orthodontic corrective treatment and the life quality of children in China: a multi-centre cohort study

Investigator(s):

McGrath CPJ, Hagg EUO

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2003

 

Abstract:

To assess the impact of severe incisor overjet on the life quality of children in China; to measure changes in the impact of oral health on the quality of life of children who undergo corrective orthodontic treatment of severe incisor overjet; to assess the correlation between changes in the magnitude of oral health related quality of life following orthodontic treatment and the improvements in alignment of teeth observed clinically.

 

List of Research Outputs

 

Bridges S.M., McGrath C.P.J. and Yiu C.K.Y., When official policies meet site-based realities: Diversity and clinical dental education in Hong Kong, Eighth International Conference on Diversity in Organisations, Communities and Nations. 2008.

 

Bridges S.M., McGrath C.P.J. and Yiu C.K.Y., Working the ‘place’ of languages in clinical dental education, 9th International Conference of the Association for Language Awareness. 2008.

 

Chong M.M., Chow T.F., Huang K.Y., Lam H.H., Lo H.Y., Tse C.M., Wong S.Y., Yu K.Y. and McGrath C.P.J., Pregnancy and oral health in Hong Kong, Journal of Dental Research. 2007, 86 (Spec Iss B): IO-72.

 

Corbet E.F., Akinwade J., Duggal R., Gebreegziabher G., Hirvikangas H., Hysi D., Katrova L., Karaharju-Suvanto T., McGrath C.P.J., Ono K., Radnai M., Schwarz E., Scott J., Sixou J.L., Soboleva U., Uoshima K., Yaneva-Ribagina K. and Fox C., Staff recruitment, development and global mobility, European Journal of Dental Education. 2008, 12 (Suppl. 1): 149-160.

 

Hagg E.U.O., McGrath C.P.J. and Zhang M., Quality of life and orthodontic treatment need related to occlusal indices, The Hong Kong Medical Diary. 2007, 12: 8-11.

 

Lau A.W.H., Wong M.C.M., Lam K.F. and McGrath C.P.J., Evaluation of child perceptions questionnaire (CPQ11-14) using structural equation modeling, Journal of Dental Research. 2007, 86 (Spec Iss B): IO-21.

 

Lee C.K., McGrath C.P.J., Wong R.W.K. and Rabie A.B.M., Patient's perceptions regarding microimplant as anchorage in orthodontics, Angle Orthodontist. 2008, 78: 228-233.

 

Lee S., McGrath C.P.J. and Samman N., Impact of orthognathic surgery on quality of life, J Oral Maxillofac Surg. 2008, 66: p. 1194-1199.

 

Lee T.C.K., Rabie A.B.M., Wong R.W.K. and McGrath C.P.J., Patients’ Perceptions Regarding Microimplant as Anchorage in Orthodontics, Outstanding Poster Award. Second International Conference on Evidence-based Advanced Dentistry, Conjoint Congress 2007. Hong Kong, China, 16 – 19 November, 2007. 2007.

 

Lo E.C.M., Wong A.H.H. and McGrath C.P.J., A randomized controlled trial of home tooth-whitening products, American Journal of Dentistry. 2007, 20: 315-318.

 

McGrath C.P.J., Chow L.P.S., Fong S.Y., Fong S.T., Liang B.M.H., Luk C.H., Tsang F.C., Wong H., Wong C.B. and Yip S.L., Improving knowledge of dental first aid through a Red Cross health promotion programme, Community Health Project Report Series. Faculty of Dentistry, The University of Hong Kong, 2008, 156: 1-32.

 

McGrath C.P.J., Chan S.Y., Chan K.T.H., Fu L.W., Fung K.C., Hon M.K., Lai C.L., Lam S.N., Wan P.C., Wong C.M. and Yung K.Y., Outreach dental services in the 'City of Sadness', Community Health Project Report Series. Faculty of Dentistry, The University of Hong Kong, 2008, 157: 1-49.

 

McGrath C.P.J., Pang H.H., Lo E.C.M., King N.M., Hagg E.U.O. and Samman N., Translation and evaluation of a Chinese version of the child oral health-related quality of life measure., Int J Paediatr Dent. 2008, 18: 267-274.

 

Mok C.W., Zhou L., McGrath C.P.J., Hagg E.U.O. and Bendeus S.A.M., Digital images as an alternative to orthodontic casts in asessessing malocclusion and orthodontic treatment need , Acta Odontol. 2007, 65: 362-268.

 

Wong M.C.M., Lau A.W.H., Lam K.F. and McGrath C.P.J., Construct validity of the short forms child perceptions questionnaire (CPQ11-14), Journal of Dental Research. 2007, 86 (Spec Iss B): IO-22.

 

Wu A.K.Y., McGrath C.P.J., Wong R.W.K. and Rabie A.B.M., A comparison of pain experienced by patients treated with labial & lingual orthodontic appliances, The 19th Convocation of the Royal Australasian College of Dental Surgeons, Conjoint with The College of Dental Surgeons of Hong Kong. Hong Kong Convention & Exhibition Centre, Hong Kong, 30 May – 2 June, 2008.

 

Zhang M., McGrath C.P.J. and Hagg E.U.O., Changes in oral health-related quality of life during fixed orthodontic appliance therapy, American Journal of Orthodontics and Dentofacial Orthopedics. 2008, 133: 25-29.

 

Zhou L., Mok C.W., Hagg E.U.O., McGrath C.P.J., Bendeus S.A.M. and Wu J.Y.C., Anteroposterior Dental Arch and Jaw-Base Relationships in a Population Sample, Angle Orthodontist. 2008, 78: 1023-1029.

 

Zhu H., McGrath C.P.J., McMillan A.S. and Li L.S.W., Can caregivers be used in assessing oral health-related quality of life among patients hospitalized for acute medical conditions?, Community Dentistry and Oral Epidemiology. 2008, 36: 27-33.

 

Zhu H., McMillan A.S., McGrath C.P.J., Li L.S.W. and Samaranayake L.P., Oral carriage of yeasts and coliforms in stroke sufferers: a prospective longitudinal study, Oral Diseases. 2008, 14(1): 60-66.

 

Researcher : Mcmillan AS

Project Title:

Orofacial Pain and its Functional and Psychosocial Impact

Investigator(s):

McMillan AS, Wong MCM, Lam CLK, Luo Y

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2005

 

Abstract:

This is a cross-disciplinary study involving the Faculties of Dentistry and Medicine that is directly related to the major research theme of Healthy Ageing.Hypotheses:o A substantial number of community-dwelling adults in Hong Kong suffer from orofacial pain (OFP) and the majority of them do not seek professional help for their condition o OFP is an under-treated condition that causes significant disability and has a serious adverse effects on people's well-being and quality of life.Purpose: To investigate a) the prevalence of OFP and its diagnostic sub-groups in community dwelling adult people in Hong Kong, b) the adverse impact of OFP on functional and psychosocial wellbeing, and c) barriers to treatment seeking for OFP symptoms.Objectives:o To determine the frequency, severity and pattern of OFP according to diagnostic sub-groups using validated patient-centred measures and clinical assessmento To describe the treatment seeking behaviour associated with OFP and factors associated with such behaviouro To assess the impact of OFP on health-related QoL using generic and condition specific health status measureso To correlate patient descriptions of OFP with clinical diagnosesPain is closely associated with poor health. The negative effect of pain on health outcomes such as function and quality of life (QoL) among patient populations is well documented (Ahmedzai, 1995). However, little is known about the impact of pain on subjective health and well-being in community dwelling populations (Reyes-Gibby et al, 2002).Although pain is a common symptom of dental and oral disease and can have a significant impact, there is a shortage of systematic data on the prevalence, severity and consequences of orofacial pain (OFP) in general, non-clinical populations (Nikias, 1985). In a community based study in Toronto, Locker & Grushka (1987) noted that 53% of participants had experienced some pain or discomfort in the orofacial region in the previous four weeks. The majority of pain reports were tooth or gum related whereas pain in the jaws, face and oral mucosa were less common.Epidemiological studies in the USA, Canada and the United Kingdom have shown that the prevalence of oro-facial pain symptoms in adult populations ranges from 14 to 40% (Lipton et al, 1993; Locker & Grushka, 1987; Macfarlane et al 2002). Gender and age-related differences in oro-facial pain prevalence have also been noted with women and younger adults at apparently greater risk of pain symptoms, whereas older people are more likely to suffer more severe pain (Macfarlane et al, 2002; Von Korff et al, 1988). Pain may have considerable impact on people's ability to perform effectively at work, home and school. Nonetheless, not everyone seeks professional help for pain with some symptoms being ignored while others may prompt action (Macfarlane et al, 2003). It is, therefore, important to discern factors that may distinguish individuals who seek professional care from those who do not. In a population-based study of OFP in the UK, Macfarlane et al (2003) noted that less than half of their study population with OFP sought professional advice. The majority of factors associated with seeking treatment appeared to be various characteristics of pain although the time course of these factors was unclear. Locker & Grushka (1987) observed that while more than 50% of their OFP study group described pain severity as moderately severe or severe, only 40 % of those reporting pain sought advice from a doctor of dentist. Ethnic differences in the perception of and means of managing pain account, at least in part, for observed differences in treatment seeking behaviour for orofacial pain conditions (Hastie et al, 2005). Socioeconomic status is also an important factor related to treatment seeking with oral disease generally more common among those least able to access health care and leads to needless pain and suffering (Riley et al, 2005).There is presently very little information on the prevalence and impact of oro-facial pain in Southern Chinese people in Hong Kong. Most oro-facial pain prevalence studies have focused on predominantly Caucasian populations. However, a recent study in Korean elders indicated that the prevalence was higher in this ethnic group and significant disability was associated with the condition (Chung et al, 2004). In a previous population-based survey, we have shown that self-reported pain symptoms associated with temporomandibular disorders are relatively common in the Hong Kong Chinese population (Pow et al, 2001). However, the characteristics of the pain differed from other ethnic groups, no gender bias in pain symptoms was observed and treatment seeking was much lower than in Caucasian counterparts. One of the problems associated with the available epidemiological data on prevalence of OFP is that it has been collected solely by means of questionnaires with patient self-reports not being confirmed by clinical assessment (Macfarlane et al, 2004). There is, therefore, the risk that patient described pain symptoms are misinterpreted and pain symptoms due to multiple conditions may go unrecognized. Definitive diagnoses can only be obtained by clinical assessment.References:Ahmedzai S. Recent clinical trials of pain control: impact on quality of life. Eur J Cancer 1995;31A(Suppl):S2-7Chung JW, Kim JH, Kim HD, Kho HS, Kim YK, Chung SC. Chronic orofacial pain among Korean elders: prevalence, and impact using the graded chronic pain scale. Pain 2004;112:164-170Hastie BA, Riley III JL, Fillingim RB. Ethnic differences and responses to pain in healthy young adults. Pain Medicine 2005;6:61-71Lipton JA, Ship JA, Larach-Robinson D. Estimated prevalence and distribution of reported orofacial pain in the United Sates. J Am Dent Assoc 1993;124:115-121Locker D, Grushka M. Prevalence of oral and facial pain and discomfort: preliminary results from a mail survey. Community Dent Oral Epidemiol 1987;15:169-172Macfarlane TV, Blinkhorn AS, Davies RM, Kincey J, Worthington HV. Factors associated with health care seeking behaviour for orofacial pain in the general population. Community Dent Health 2003;20:20-26Macfarlane TV, Blinkhorn AS, Craven R et al. Can one predict the likely specific orofacial pain syndrome from a self-completed questionnaire? Pain 2004;111:270-277Nikias M. Oral disease and the quality of life. Am J Public Health 1985;75:11-12Reyes-Gibby C, Aday L, Cleeland C. Impact of pain on self-related health in community-dwelling older adults. Pain 2002;95:75-82Riley III JL, Gilbert GH. Orofacial pain symptoms: an interaction between age and sex. Pain 2001;90:245-256Von Korff M, Ormel J, Keefe FJ, Dworkin SF. Grading the severity of chronic pain complaints. Pain 1988;32:173-183

 

Project Title:

Predictors of outcome of orofacial pain: A community-based longitudinal study

Investigator(s):

McMillan AS, Wong MCM, Lam CLK, Luo Y, Zheng J

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2006

 

Abstract:

This is a cross-disciplinary study involving the Faculties of Dentistry and Medicine that is directly related to the major research theme of Healthy Ageing.Purpose: To investigate a) the pain characteristics in community-dwelling adult Hong Kong Chinese people with OFP, b) to follow-up OFP sufferers over a 6-month period and identify presenting factors and behaviours that predict poor outcome. Null hypotheses:- Orofacial pain does not tend to persist - There are no factors that can predict the persistence of OFPObjectives:o To describe the outcome of OFP after a period of 6-monthso To identify baseline factors that predict poor outcome in adults with OFPOrofacial pain (OFP) may be defined as pain related to the face and/or mouth and involves both hard and soft tissues in these anatomical regions. Epidemiological studies in the USA, Canada and the United Kingdom have shown that the prevalence of OFP symptoms in adult populations ranges from 14 to 40%.1-3 In a population-based survey of OFP symptoms in adult Chinese people in Hong Kong, the one-month period prevalence of OFP (42%) was found to be consistent with estimates in western countries.4 Pain is closely associated with poor health and may considerably impair people's ability to perform daily living activities. Despite this, not all pain sufferers seek professional help with some symptoms being ignored whilst others prompt attention. (2,3,5,6). In studies involving western cohorts 44-46% with OFP sought professional help (2,5,6). However, only 20% of Hong Kong Chinese adults with OFP symptoms sought professional treatment.4 Thus, it is important to explore the factors and barriers relating to professional treatment seeking behaviour in order to understand the disparity between Chinese adults and their western counterparts. MacFarlane et al5 noted that pain characteristics appeared to prompt treatment seeking although the time course of these factors was unclear. The decision to seek treatment may be related to the consequences of the OFP as experienced by the individual and also affected by culturally-mediated responses to the pain experience and its consequences (7). A key characteristic of OFP is that it tends to persist (8). In a longitudinal study in the United Kingdom, over half those with OFP at baseline reported pain four years later (9). Persistent pain was associated with females, increasing age, psychological distress, widespread body pain and taking pain medication at baseline. In a Swedish cohort, the follow-up of 109 patients with OFP revealed that after 4 to 9 years only 27% had resolution of the pain, with pain medication usage at baseline a strong predictor of persistent OFP (10). The consequences of OFP have an impact on various aspects of daily life and include work loss, sleep disturbance, need for more rest, avoidance of social contacts, and difficulty eating and speaking (2,11). The magnitude of the impact appears to be related to the pain characteristics and socio-demographics of the respondents (2,3,11). Pain-related sleep disturbance is also a key determinant of seeking professional treatment (6). There is scant information available on the characteristics of OFP in southern Chinese people, its potential to persist and the functional and psychosocial impact. In a population-based survey of symptoms of temporomandibular disorders in Hong Kong Chinese people, jaw pain, restricted jaw opening and jaw clicking were the most common presenting symptoms and often associated with significant morbidity (12). In contradistinction to western studies, there were no gender-related differences in symptom reporting or treatment seeking (12). In a recent study of chronic OFP in elderly Koreans the prevalence appeared to be higher compared with Caucasian populations.13Adverse impacts were common with around 30% of those with joint pain, toothache and burning mouth symptoms having significant associated disability and impairment of daily living activities (13). The ideal approach to the investigation of OFP in the community is by interview using validated questionnaires and clinical assessment. However, most studies where patient-based and clinical data are available involve a bias sample of people seeking treatment. In epidemiological studies of OFP, the most common means of obtaining information is by questionnaire, by mail or telephone survey, without clinical examination of the participants. Even with contemporary questionnaire approaches, without clinical assessment, there is always the issue of data reliability. References 1. Lipton JA, Ship JA, Larach-Robinson D. Estimated prevalence and distribution of reported orofacial pain in the United States. J Am Dent Assoc 1993;124:115-21.2. Locker D, Grushka M. Prevalence of oral and facial pain and discomfort: preliminary results of a mail survey. Community Dent Oral Epidemiol 1987a;15:169-72.3. Macfarlane TV, Blinkhorn AS, Davies RM, Kincey J, Worthington HV (2002). Oro-facial pain in the community: prevalence and associated impact. Community Dent Oral Epidemiol 30(1):52-60.4. McMillan AS, Wong MCM, Zheng J, Lam CLK. Prevalence of orofacial pain and treatment seeking in Hong Kong Chinese. J Orofac Pain (in press) 5. Macfarlane TV, Blinkhorn AS, Davies RM, Kincey J, Worthington HV. Factors associated with health care seeking behaviour for orofacial pain in the general population. Community Dent Health 2003;20:20-26.6. Locker D. The symptom iceberg in dentistry. Treatment-seeking in relation to oral and facial pain. J Can Dent Assoc 1988:54:271-4.7. Hastie BA, Riley JL, Fillingim RB. Ethnic differences and responses to pain in healthy young adults. Pain Med 2005;6:61-71.8.Von Korff M, Ormel J, Keefe F, Dworkin S (1992). Grading the severity of chronic pain. Pain 50(2):133-149.9.Macfarlane TV, Blinkhorn AS, Davies RM, Kincey J, Worthington HV. Predictors of outcome for orofacial pain in the general population: a four-year follow-up study. 2004 J Dent Res ;83:712-7.10. Wolf E, Nilner M, Petersson A, Petersson K (2002). Long-term follow-up by means of a questionnaire of 109 patients with long-lasting orofacial pain. Swed Dent J. 26(3):125-34.11. Locker D, Grushka M. The impact of dental and facial pain. J Dent Res 1987;66:1414-7.12. Pow EHN, Leung KCM, McMillan AS. Prevalence of symptoms associated with temporomandibular disorders in Hong Kong Chinese. J Orofac Pain 2001;15:228-34.13. Chung JW, Kim JH, Kim HD, Kho HS, Kim YK, Chung SC. Chronic orofacial pain among Korean elders: prevalence, and impact using the graded chronic pain scale. Pain 2004;112:164-70.

 

List of Research Outputs

 

Lee L.T.K., Yeung R.W.K., Wong M.C.M. and McMillan A.S., Diagnostic sub-types, psychological distress and psychosocial dysfunction in southern Chinese people with temporomandibular disorders, Journal of Oral Rehabilitation. 2008, 35(3): 184-90.

 

Leung K.C.M., McMillan A.S., Cheung B.P.K. and Leung W.K., Sjögren's syndrome sufferers have increased oral yeast levels despite regular dental care, Oral Diseases. 2008, 14: 163-173.

 

Leung K.C.M., Leung W.K. and McMillan A.S., Supra-gingival microbiota in Sjögren's syndrome, Clinical Oral Investigations. 2007, 11: 415-423.

 

Leung K.C.M., McMillan A.S., Wong M.C.M., Leung W.K., Mok T.M.Y. and Lau C.S., The efficacy of cevimeline hydrochloride in the treatment of xerostomia in Sjögren's syndrome in southern Chinese patients: a randomised double-blind, placebo-controlled crossover study, Clinical Rheumatology. 2008, 27: 429-436.

 

Perera R.A.P.M., Tsang P.C.S., Li P., Lee M.P., Samaranayake L.P. and McMillan A.S., Oral Manifestations of ethnic Chinese HIV-infected adults on HAART, Inaugural Conjoint Dedntal Scientific Meeting. The University of Hong Kong and Wuhan University 2008.. 2008.

 

Pow E.H.N., Chan K.H.C., Luk W.K., Dias A.P.L.H. and McMillan A.S., Effect of laboratory procedures on casting magnetic keepers with gold alloy, Inaugural Conjoint Dental Scientific Meeting of the University of Hong Kong and Wuhan University. 2008.

 

Pow E.H.N., Botelho M.G., Chow T.W., Dias A.P.L.H., Dyson J.E., Leung K.C.M. and McMillan A.S., Student's manual to the BDS V Prosthodontic Clinical Skills and Technology Course in Oral Rehabilitation 2007-2008. Hong Kong, 2007, 1-76.

 

Pow E.H.N., Botelho M.G., Chow T.W., Dias A.P.L.H., Dyson J.E., Leung K.C.M. and McMillan A.S., Teacher's manual to the BDS V Prosthodontic Clinical Skills and Technology Course in Oral Rehabilitation 2007-2008. Hong Kong, 2007, 1-89.

 

Tsang P.C.S., Ng H. and McMillan A.S., Antifungal susceptibility of Candida albicans biofilms on titanium discs with different surface roughness, Clinical Oral Investigations. 2007, 11(4): 361-8.

 

Zhu H., McGrath C.P.J., McMillan A.S. and Li L.S.W., Can caregivers be used in assessing oral health-related quality of life among patients hospitalized for acute medical conditions?, Community Dentistry and Oral Epidemiology. 2008, 36: 27-33.

 

Zhu H., McMillan A.S., McGrath C.P.J., Li L.S.W. and Samaranayake L.P., Oral carriage of yeasts and coliforms in stroke sufferers: a prospective longitudinal study, Oral Diseases. 2008, 14(1): 60-66.

 

Researcher : Mei L

List of Research Outputs

 

Mei L., Fang H.H.P., Zhang T., Jin L.J. and Yip H.K., The use of chlorhexidine in reducing the cariogenicity of oral microbial biofilm with caries free and high risk of caries. , the Inaugural Conjoint Dental Scientific Meeting The University of Hong Kong and Wuhan University.. China, 2008, 38.

 

Researcher : Mok WH

List of Research Outputs

 

Chau C.M., Li T.K.L. and Mok W.H., 3D models showing relationship between horizontally impacted mandibular third molars and inferior dental canals using computed tomographic images, In: Balaji SM, Indian Journal of Maxillofacial & Oral Surgery. India, The Association of Oral and Maxillofacial Surgeons of, 2007, 6: 17-21.

 

Researcher : Newsome PRH

Project Title:

All-porcelain crowns in general dental practice. A qualitative and clinical study

Investigator(s):

Newsome PRH

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2006

 

Abstract:

Restorative dentistry has changed dramatically in recent years. The introduction of a variety of indirect all-porcelain crown systems (eg Empress II. Cercon, Procera) has allowed dentists to place restorations that are not only aesthetic but also durable and conservative. Case selection, material choice, appropriate tooth preparation and cementation of such restorations are, however, considered to be critical and demand close adherence to a set of clinical principles if they are to be successful. Little is known of a) dentists' views and accordingly the willingness of dentists to offer them to their patients and b) the clinical ability of dentists to conform to the aforementioned principles. The aim of this research is to explore the use of such restorations in dental practice. It will also examine the level and nature of communication between dentists and laboratories, widely viewed as a critical determinant of success. Specificically, it is proposed to examine Hong Kong dentists': 1) opinions of, and experience with, the new generation of all-porcelain restorations 2) understanding of accepted principles regarding case selection and tooth preparation with respect to all-porcelain restorations 3) communication with the dental laboratory 4) assessment of all-porcelain restorations supplied by the dental laboratory

 

List of Research Outputs

 

Newsome P.R.H., 'Old' dentistry, 'New' dentistry - is change always for the best?, Word of Mouth. 2008, 59-61.

 

Newsome P.R.H., Attracting, retaining and caring for patients, Independent Seminars. Private Dentistry 07, London UK. 2007.

 

Newsome P.R.H., Ceramic veneers for the general dental practitioner, Annual academic sessions of the College of General Dental Practitioners. Colombo, Sri Lanka. 2008.

 

Newsome P.R.H., Ceramic veneers in general dental practice. Part five: After care and dealing with failure, Aesthetic Dentistry Today. 2008, 2(4): 10-13.

 

Newsome P.R.H. and Owen S., Ceramic veneers in general dental practice. Part four: Clinical procedures 2, Aesthetic Dentistry Today. 2008, 2(3): 9-14.

 

Newsome P.R.H. and Owen S., Ceramic veneers in general dental practice. Part one. Treatment planning, Aesthetic Dentistry Today. 2007, 1(4): 8-15.

 

Newsome P.R.H. and Owen S., Ceramic veneers in general dental practice. Part three. Clinical Procedures, Aesthetic Dentistry Today. 2008, 2(2): 9-15.

 

Newsome P.R.H. and Owen S., Ceramic veneers in general dental practice. Part two. Choice of materials, Aesthetic Dentistry Today. 2008, 2(1): 8-14.

 

Newsome P.R.H., Dental practice management training, Dentistry. London, UK, FMC Ltd, 2007, 8: 43.

 

Newsome P.R.H., Ethical selling in dentistry. London, Stephen Hancocks Ltd, 2007.

 

Newsome P.R.H., Managing and motivating the dental team, Independent Seminars. Private Dentistry 07, London UK. 2007.

 

Newsome P.R.H., Marketing and ethical selling, UK Bicon Practitioners' meeting. London, UK, 2008.

 

Newsome P.R.H., Old dentistry, new dentistry - is there any difference?, British Dental Association Conference. Manchetser, UK, 2008.

 

Newsome P.R.H., Success in dental practice. An approach for the 21st century, Annual academic sessions of the College of General Dental Practitioners. Colombo, Sri Lanka, 2008.

 

Newsome P.R.H., Team Dynamics, Independent Seminars Private Dentistry 07, London UK. 2007.

 

Newsome P.R.H. and Diamond M., The Aesthetic Journey. One Day Course, General Dental Practitioners, Belfast, Ireland. 2007.

 

Researcher : Ng H

List of Research Outputs

 

Tsang P.C.S., Ng H. and McMillan A.S., Antifungal susceptibility of Candida albicans biofilms on titanium discs with different surface roughness, Clinical Oral Investigations. 2007, 11(4): 361-8.

 

Researcher : Ng SKS

List of Research Outputs

 

Ng S.K.S. and Leung W.K., A community study of periodontal attachment loss in smokers, Journal of Dental Research. 2007, 86 (Spec Iss B): IO-11.

 

Wong R.M.S., Ng S.K.S., Corbet E.F. and Leung W.K., Oral health-related quality of life changes upon non-surgical periodontal therapy, Journal of Dental Research. 2007, 86 (Spec Iss B): IP-139.

 

Researcher : Ng TCS

List of Research Outputs

 

Hagg E.U.O., Ng T.C.S. and Wong R.W.K., Anterior Bite: Interceptive Treatment, Dental Asia. 2008, September/October 2007: 39-45.

 

Researcher : Ow ATC

List of Research Outputs

 

Ow A.T.C. and Cheung L.K., Outstanding Oral Presentation Award at the Second International Conference on Evidence-Based Advanced Dentistry, Hong Kong, 16-19 November 2007. 2007.

 

Researcher : Pan H

List of Research Outputs

 

Pan H. and Darvell B.W., Solubility of calcium fluoride and fluorapatite by solid titration, Archives of Oral Biology. Elsevier, 2007, 52: 861-868.

 

Pan H. and Darvell B.W., Solubility of hydroxyapatite by solid titration at pH3-4, Archives of Oral Biology. Elsevier, 2007, 52: 618-624.

 

Researcher : Pang HH

List of Research Outputs

 

McGrath C.P.J., Pang H.H., Lo E.C.M., King N.M., Hagg E.U.O. and Samman N., Translation and evaluation of a Chinese version of the child oral health-related quality of life measure., Int J Paediatr Dent. 2008, 18: 267-274.

 

Researcher : Parahitiyawa NB

List of Research Outputs

 

Samaranayake Y.H., Samaranayake L.P., Cheung B.P.K., Parahitiyawa N.B., Yau J.Y.Y. and Yeung S.K.W., Synergistic Inhibition of Candida biofilms by Lysozyme and Common Antifungals , Inaugural Conjoint Dental Scientific Meeting. The University of Hong Kong and Wuhan University 2008.

 

Researcher : Perera RAPM

List of Research Outputs

 

Perera R.A.P.M., Tsang P.C.S., Li P., Lee M.P., Samaranayake L.P. and McMillan A.S., Oral Manifestations of ethnic Chinese HIV-infected adults on HAART, Inaugural Conjoint Dedntal Scientific Meeting. The University of Hong Kong and Wuhan University 2008.. 2008.

 

Researcher : Pow EHN

Project Title:

Oral yeast profile of nasopharyngeal carcinoma patients after intensity-modulated radiotherapy

Investigator(s):

Pow EHN, McMillan AS, Leung WK

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

 

Abstract:

To investigate oral colonization and phenotypic profile of oral yeasts in nasopharyngeal carcinoma (NPC) patients receiving conventional radiotherapy (CT) versus intensity-modulated radiotherapy (IMRT).

 

Project Title:

The impact of adjuvant chemotherapy on the quality of life of patients receiving radiotherapy for nasopharyngeal carcinoma

Investigator(s):

Pow EHN, McMillan AS, Kwong DLW, Wong MCM

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

12/2006

 

Abstract:

To compare oral health related quality of life in nasopharyngeal carcinoma (NPC) patients receiving radiotherapy (RT) versus radiotherapy plus chemotherapy (RTCH)

 

List of Research Outputs

 

Luk W.K., Pow E.H.N. and Dias A.P.L.H., A Qualtiy Assessment of the Casting Process on Magnetic Keepers, Journal of Prosthodontics. 2007, 16: 249-254.

 

Pow E.H.N., Chan K.H.C., Luk W.K., Dias A.P.L.H. and McMillan A.S., Effect of laboratory procedures on casting magnetic keepers with gold alloy, Inaugural Conjoint Dental Scientific Meeting of the University of Hong Kong and Wuhan University. 2008.

 

Pow E.H.N., Immediate implant following tooth extraction, Dental South China International Expo 2008. 2008.

 

Pow E.H.N., Implant prosthodontics – a multidisciplinary approach, 2nd International Conference on Evidence-based Advanced Dentistry, Faculty of Dentistry and The College of Dental Surgeons of Hong Kong. 2007.

 

Pow E.H.N., Implant prosthodontics: managing difficulties and complications, Hong Kong Dental Association. 2007.

 

Pow E.H.N., Management of complications in implant prosthodontic procedures, Guanghua School of Stomatology, Sun Yat-Sen University. 2007.

 

Pow E.H.N., Oral Care of patients with nasopharyngeal carcinoma, Oral and Dental Care programme, RTHK. 2007.

 

Pow E.H.N. and Leung K.C.M., Recent innovations in dental implantology, Expressions. 2008, 2: 11.

 

Pow E.H.N., Replacing missing teeth, Dental Society, HKUSU. 2007.

 

Pow E.H.N., Botelho M.G., Chow T.W., Dias A.P.L.H., Dyson J.E., Leung K.C.M. and McMillan A.S., Student's manual to the BDS V Prosthodontic Clinical Skills and Technology Course in Oral Rehabilitation 2007-2008. Hong Kong, 2007, 1-76.

 

Pow E.H.N., Botelho M.G., Chow T.W., Dias A.P.L.H., Dyson J.E., Leung K.C.M. and McMillan A.S., Teacher's manual to the BDS V Prosthodontic Clinical Skills and Technology Course in Oral Rehabilitation 2007-2008. Hong Kong, 2007, 1-89.

 

Pow E.H.N., What can dental laboratories do to minimize your troubles in implant treatment?, 2nd International Conference on Evidence-based Advanced Dentistry, Faculty of Dentistry and The College of Dental Surgeons of Hong Kong. 2007.

 

Researcher : Rabie ABM

Project Title:

Use of micro-implants in orthodontics

Investigator(s):

Rabie ABM, Wong RWK

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

01/2006

 

Abstract:

To investigate the use of mini-implant in orthodontics

 

Project Title:

A novel treatment for Skeletal Class II malocclusion in young adults - a Bone Borne Mandibular Distractor

Investigator(s):

Rabie ABM, Cheung LK, Wong RWK, Dyson JE

Department:

Dental Faculty

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

10/2006

 

Abstract:

(1) Enhancing the reactivation of condylar growth in young adults and late adolescents based on findings in experimental and clinical research. We aim to increase the skeletal component of the correction by avoiding the proclination of the lower incisors that occurs with the Herbst appliance. This reduces the overjet, the amount of advancement and skeletal correction. (2) The forces that this distractor will be exposed to in situ and hence the requisite bone plate configurations, screw length and diameter will be investigated. (3) The question of how to evaluate the response to treatment will also be addressed. In addition to traditional radiographic methods we will use new developments in 3D Magnetic Resonance Imaging.

 

Project Title:

Effect of naringin on oral microgranisms

Investigator(s):

Rabie ABM, Wong RWK

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

01/2007

 

Abstract:

IntroductionExtensive research has been done in the search of ideal bone grafting/ bone induction materials. However, bacterial colonization/re-infection of the surgical site has proven to be detrimental on the healing process.Naringin is a flavonoid that can be commonly found in edible citrus fruit. It was proven in our laboratory, that naringin in collagen can significantly increase new bone formed in rabbit skull defects.ObjectiveThe objective of this study will be to evaluate the effect of naringin on the viability and proliferation of oral microbes in vitro. Common oral aerobes, candida species, and anaerobes such as (Actinobacillus actinomycetemocomitans Aa) will be included in the study.

 

List of Research Outputs

 

Al Khal H.A., Wong R.W.K. and Rabie A.B.M., Elimination of Hand-Wrist Radiographs for Maturity Assessment in Children Needing Orthodontic Therapy, Skeletal Radiology 2008. 2007, 37: 195-200.

 

Alkhal H.A., Wong R.W.K. and Rabie A.B.M., Correlation between Chronological Age, Cervical Vertebral Maturation and Fishman’s Skeletal Maturity Indicators in Southern Chinese, Angle Orthodontist. 2008, 78, No.4: 591-596.

 

Bryndahl F., Warfvinge G., Rabie A.B.M. and Isberg A., Subchondral bone resorption induced by TMJ disk displacement explains subsequent adverse mandibular growth., In: Fredrik Bryndahl. Umea University, Temporomandibular joint disk displacement and subsequent adverse mandibular growth - A radiographic, histologic and biomolecular experimental study. 2008, IV: 1-9.

 

Cendekiawan T., Wong R.W.K. and Rabie A.B.M., Temporal Expression of SOX9 and Type II Collagen in Spheno-Occipital Synchondrosis of Mice after Mechanical Tension Stimuli. , Angle Orthodontist. 2007, 78 No. 1: 83-88.

 

Dai J. and Rabie A.B.M., Gene therapy to enhance condylar growth using rAAV-VEGF, Angle Orthodontist. 2008, 78: 89-94.

 

Dai J. and Rabie A.B.M., VEGF: an essential mediator of both angiogenesis and endochondral ossification, Critical Reviews in Oral Biology & Medicine [incorporated in the Journal of Dental Research]. 2007, 86: 937-950.

 

Finn G., Rabie A.B.M. and Wong R.W.K., Inhibitory effect of Quercetin on Periodontal pathogens, The 19th Convocation of the Royal Australasian College of Dental Surgeons, Conjoint with The College of Dental Surgeons of Hong Kong. Hong Kong Convention & Exhibition Centre, Hong Kong, 30 May – 2 June, 2008.

 

Lee C.K., McGrath C.P.J., Wong R.W.K. and Rabie A.B.M., Patient's perceptions regarding microimplant as anchorage in orthodontics, Angle Orthodontist. 2008, 78: 228-233.

 

Lee T.C.K., Rabie A.B.M., Wong R.W.K. and McGrath C.P.J., Patients’ Perceptions Regarding Microimplant as Anchorage in Orthodontics, Outstanding Poster Award. Second International Conference on Evidence-based Advanced Dentistry, Conjoint Congress 2007. Hong Kong, China, 16 – 19 November, 2007. 2007.

 

Lee T.C.K., Leung M.T.C., Wong R.W.K. and Rabie A.B.M., Versatility of skeletal anchoarage in orthodontics, World Journal of Orthodontics. 2008, 9: 221-232.

 

Lei S.W.Y., Wong R.W.K. and Rabie A.B.M., Factors Regulating Endochondral Ossification in the Spheno-occipital Synchondrosis. , Angle Orthodontist . 2007, 78, No.2: 215-220.

 

Leung M.T.C., Lee T.C.K., Rabie A.B.M. and Wong R.W.K., Stability of connected mini-implants and miniplate for skeletal anchorage in orthodontics, European Journal of Orthodontics. 2008, 30: 483-489.

 

Leung M.T.C., Lee T.C.K., Rabie A.B.M. and Wong R.W.K., Use of Miniscrews and Miniplates in Orthodontics, Journal of Oral and Maxillofacial Surgery 2008. 2008, 66: 1461-1466.

 

Li Q. and Rabie A.B.M., A new approach to control condylar growth by regulating angiogenesis, Archive of Oral Biology. 2007, 52: 1009-1017.

 

Purkayastha S.L., Rabie A.B.M. and Wong R.W.K., Treatment of skeletal Class II malocclusion in adults: Stepwise vs single-step advancement with the Herbst appliance, World Journal of Orthodontics. 2008, 9: 233-243.

 

Rabie A.B.M., A bag of tricks- your guide to management of comprehensive orthodontic problems; An alternative to surgical correction of skeletal class II in adults; Management of orthodontics, patients with severe bone loss, Bond with the Best III Symposium, Pune, India. 2008.

 

Rabie A.B.M. and Al K.A.A.A., Does the degree of advancement during functional appliance therapy matter?, European Journal of Orthodontics. 2008, 30: 274-282.

 

Rabie A.B.M., Gene therapy in clinical dentistry, 2nd International Conference in Evidence-based Advanced Dentistry, Hong Kong. 2007.

 

Rabie A.B.M., Management of adult orthodontic patients with severe bone loss using intrusion with bone induction; Bone induction in dentistry; Growth modifications in young and in adults; Esthetic dentistry & orthodontics, 25th Anniversary of Center for Orthodontic Study, Gent, Belgium. 2008.

 

Rabie A.B.M., Mandibular growth: from functional appliances to gene therapy, 108th Annual session of American Association of Orthodontists, Denver, USA. 2008.

 

Rabie A.B.M., Dai J. and Xu R., Recombinant AAV-mediated VEGF gene therapy induces mandibular condylar growth, Gene Therapy. 2007, 14: 972-980.

 

Rabie A.B.M., Regeneration of periodontium achieve stability in adults with severe bone loss, 6th Asian Pacific Orthodontic Conference, Bangkok, Thailand. 2008.

 

Rabie A.B.M., Regeneration of periodontium to achieve stability in adults with severe bone loss: Part I & Part II, Joint Commonwealth Dental Association & 6th Penang Scientific Congress, Penang, Malaysia. 2007.

 

Rabie A.B.M., Wong R.W.K. and Gu M., Treatment in borderline Class III malocclusion: orthodontic camouflage (extraction) versus orthognathic surgery, The Open Dentistry Journal. 2008, 2: 38-48.

 

Tsui V.W.K., Wong R.W.K. and Rabie A.B.M., The Inhibitory Effect of Naringin on The Growth of Periodontal Pathogens In Vitro. , Phytotherapy Research . 2008, 22: 401-406.

 

Twitty A. and Rabie A.B.M., An immunolocalization study of tissue inhibitors and metalloproteinase-1 of bone graft healing on parietal bone, Journal of Craniofacial Surgery. 2008, 19: 393-397.

 

Wong R.W.K. and Rabie A.B.M., Chapter IV - Herbal Drug Research on Bone Regeneration , In 'Chinese Herbal Drug Research'. Nova Science Publishers, Inc. New York. 2008. ISBN: 1-60021-928-4. 2008, 123-145.

 

Wong R.W.K. and Rabie A.B.M., Chinese Medicinal Plants in Arthritis, Volume 20 of the Series - Recent Progress in Medicinal Plants' Phytopharmacology and Therapeutic Values II. . LLC, USA, Stdium Press, 2007, 20.

 

Wong R.W.K. and Rabie A.B.M., Chinese red yeast rice (Monascus purpureus-fermented rice) promotes bone formation, Chinese Medicine. 2008, 3: 4.

 

Wong R.W.K. and Rabie A.B.M., Effect of Danshen extract on Bone Formation, The 19th Convocation of the Royal Australasian College of Dental Surgeons, Conjoint with The College of Dental Surgeons of Hong Kong. Hong Kong Convention & Exhibition Centre, Hong Kong, 30 May – 2 June, 2008.

 

Wong R.W.K. and Rabie A.B.M., Effect of Quercetin on Preosteoblasts and Bone Defects, The Open Orthopaedics Journal. 2008, Vol. 2: 27-32.

 

Wong R.W.K. and Rabie A.B.M., Effect of Salvia miltiorrhixa extract on bone formation, Journal of Biomedical Materials Research 2008 . 2008, 85A: 506-512.

 

Wong R.W.K. and Rabie A.B.M., Local Massage with Topical Analgesic, a Novel Treatment Modality for Temporomandibular Muscular Pain, a Case Study Report of 5 Consecutive Cases., Open Orthopaedics Journal . 2008, 2: 93-98.

 

Wong R.W.K. and Rabie A.B.M., Local message with topical analgesic, a novel treatment modality for temporomandibular muscular pain, a case study report of 5 consecutive cases, The Open Orthopaedics Journal. 2008, 2: 93-98.

 

Wong R.W.K., Rabie A.B.M., Bendeus M. and Hagg E.U.O., The effects of Rhizoma Curculiginis and Rhizoma Drynariae extracts on bones , Chinese Medicine . 2007, 2: 1-13.

 

Wong R.W.K. and Rabie A.B.M., The use of HMG-CoA reductase inhibitors as bone induction materials. , In: Bloomington D.R., Nova Science Publishers, Inc, New York, New Research on Biomaterials.. 2007, 1-48.

 

Wu A.K.Y., McGrath C.P.J., Wong R.W.K. and Rabie A.B.M., A comparison of pain experienced by patients treated with labial & lingual orthodontic appliances, The 19th Convocation of the Royal Australasian College of Dental Surgeons, Conjoint with The College of Dental Surgeons of Hong Kong. Hong Kong Convention & Exhibition Centre, Hong Kong, 30 May – 2 June, 2008.

 

Researcher : Ren L

List of Research Outputs

 

Ren L., Jin L.J. and Leung W.K., The in vivo expression patterns of IL-1b and IL-10 in chronic periodontitis, Chinese Journal of Stomatological Research. 2007, 1: 21-24.

 

Researcher : Sam K

List of Research Outputs

 

Lam B., Sam K., Lai A.Y.K., Lam J.C.M., Lam D.C.L. and Ip M.S.M., The efficacy of oral appliance in the treatment of severe obstructive sleep apnea, 13th Medical Research Conference, Department of Medicine, HKU. 2008, Abstract.

 

Researcher : Samaranayake LP

Project Title:

Molecular epidemiology of geopraphically diverse oral Candida tropicalis isolates

Investigator(s):

Samaranayake LP

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2002

 

Abstract:

To investigate the RAPD fingerprints of C. tropicalis isolates from varying geographical locales using tDNA and rDNA directed sequence-specific and arbitrary primers in order to asses their genomic heterogeneity; to investigate their intraspecies genetic relatedness as a recent report has hinted the possible existence of a genetic variant of this yeast which may be classified as a new species.

 

Project Title:

Ultrastructural, histochemical and molecular features of the invasive phase of Candida species

Investigator(s):

Samaranayake LP, Cheung LK, Samaranayake YH

Department:

Dental Faculty

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

12/2002

 

Abstract:

The study attempts to:- 1) characterize the ultrastructural cellular features of the three hypha producing Candida species, C. albicans, C. tropicalis and C. dubliniensis, during invasion of the superficial epithelium; 2) determine qualitatively the proteolytic and lipolytic enzymes secreted at the apical tip of the invading fungal hyphae; 3) examine th etemporal regulation of the mRNA expression of seven members of the secreted aspartyl proteinases (SAP) gene family during tissue invasion by C. albicans; and 4) evaluate features mentioned above in well characterized mutants of C. albicans that have a high and low propensity to produce hyphal elements and SAP mutants that have defects in secretion of this protein degrading enzyme.

 

Project Title:

Development and validation of a mutiarray Candida biofilm device

Investigator(s):

Samaranayake LP

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

12/2005

 

Abstract:

Candida species can exist as either commensals or opportunistic pathogens with the ability to cause a variety of superficial to systemic infections mainly in immunocompromised individuals (Samaranayake et al 2002). The major fungal species isolated from these patients is the polymorphic C. albicans (which can grow as blastospores, pseudohyphae or hyphae, and also form chlamydospores) recovered from medical devices such as central venous catheters, prosthetic heart valves, artificial voice prostheses and intrauterine devices (Hawser and Douglas, 1994, Samaranayake et al 2005). The primary event in Candida infections is their adherence to a host surface or a prosthesis leading to the formation of a biofilm which further facilitate adhesion and infection. Once established, Candida biofilms serve as a persistent reservoir of infection and in addition they offer greater resistance to antifungal agents than planktonic phase yeasts Apart from C. albicans other non-albicans species especially, C. glabrata, C. parapsilosis, C krusei and C. tropicalis are increasingly recognized as nosocomial pathogens of clinical interest (Samaranayake 2000). Several different in vitro Candida biofilm model systems have been developed to study the many features of the sessile yeast form in comparison to the planktonic form. These include biofilms grown on intravascular catheter discs, acrylic discs, cylindrical cellulose filters, those developed using perfused biofilm fermenters and the modified Robbins device (Hawser and Douglas, 1994, Ye 2004). Although these experimental systems mimic to some extent the natural in vivo physiology of Candida biofilms a simple, rapid and reproducible, mutiarray method for screening a number of different Candida strains or species and factors that affect their biofilm formation has not yet been developed. Calgary biofilm device (CBD) is a system used by bacteriologists to determine antibiotic susceptibility of multiple arrays of bacteria within a single experimental system (Ceri et al., 1999). We plan to develop the CBD for standardization of C. albicans biofilms and then demonstrate the feasibility of the system to study the relative rate of biofilm production by five other medically important Candida species. In addition we propose to use the CBD method to evaluate the growth kinetics of C. albicans biofilms and, the effect of five different dietary carbohydrates on Candida biofilm development. The biofilm ultrastructure of C. albicans, C. dubliniensis, C. glabrata, C. tropicalis, and C. krusei using the CBD over a period five days will also be studied using SEM. References 1. Ceri H, OlsonME , Stremick C et al (1999) The calgary biofilm device: new technology for rapid determination of antibiotic susceptibilities in bacterial biofilms. J. Clin. Microbiol. 37; 1771–1776 2. Hawser, S. P., and L. J. Douglas. 1994. Biofilm formation by Candida species on the surface of catheter materials in vitro. Infect. Immun. 62:915-921 3. Samaranayake LP Essential microbiology for dentistry Churchill Livingstone 2000 4. Samaranayake LP, Cheung LK, Samaranayake YH Candidiasis and other fungal diseases of the mouth Dermatologic Therapy 2002 ; 15: 252-270. 5. Jin Y, Samaranayake LP, Samaranayake YH, Yip HK. Biofilm Formation of Candida albicans is variably affected by saliva and dietary sugars. Archives of Oral Biology. 2004; 49: 789-798 6. Samaranayake YH , Dassanayake RS Jayatilake JAMS, Cheung BPK, Yau JYY, Yeung KWS, Samaranayake LP Phospholipase B enzyme expression is not associated with other virulence attributes in Candida albicans isolates from patients with human immunodeficiency virus infection Journal of Medical Microbiology 2005 ; 54 : 583-593

 

Project Title:

Effect of oral bacteria on growth and survival of Candida albicans biofilms

Investigator(s):

Samaranayake LP, Samaranayake YH

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

09/2006

 

Abstract:

In nature, most microorganisms exist in polymicrobial communities, and significant proportions persist attached to surfaces in the form of biofilms (Costerton et al., 1987). A biofilm is defined as an assemblage of microorganisms and their extracellular products at an interface and typically attached to an abiotic or biotic surface. It is now known that the complex architecture of most biofilms is intrinsically stratified into spatially organised populations of mixed species communities with a degree of interspecies interaction (El Azizi et al., 2004). Several workers have previously described marked variations in the interactions between bacteria and C. albicans with complex outcomes although none has co-cultured bacteria and yeast for a prolonged period to evaluate biofilm formation. For example, in very early studies Bagg and Silverwood (1986) demonstrated binding of oral streptococci to C. albicans and surmised that such coaggregation was one mechanism by which the opportunistic pathogen C. albicans survives within the hostile oral milieu. Millsap et al., (1999) found the salutary effect of oral streptococci and Actinomyces species on the subsequent adhesion of C. albicans to acrylic surfaces in a parallel plate flow chamber. These and other studies have described essentially the beneficial aspects of such interactions although it is likely that antagonistic interactions also play an important role in a mixed biofilm (Bagg and Silverwood, 1986; Grimaudo et al., 1996; Grimaudo and Nesbitt, 1997). As far as we are aware, there are no studies in the English language literature on the effect of oral bacteria on the C. albicans biofilm development over a prolong period of 48 h. Therefore, the aim of this study is to evaluate the effect of varying concentrations of eight different aerobic and anaerobic oral bacteria on C. albicans biofilm formation. Four different plaque organisms namely Actinomyces israelii, Lactobacillus acidophilus, Streptococcus mutans, Streptococcus intermedius, and two periodontopathic, black-pigmented, anaerobes, Prevotella nigrescens, and Porphyromonas gingivalis and two transient oral colonizers, Pseudomonas aeruginosa, and Escherichia coli.ReferencesBagg, J. and Silverwood, R. W. (1986). J. Med. Microbiol. 22: 165-169.Costerton, J. W. et al. (1987). Annu. Rev. Microbiol. 41: 435-464.El Azizi, M. A. et al. (2004). J. Appl. Microbiol. 96: 1067-1073. Grimaudo, N. J. et al. (1996). Oral Microbiol. Immunol. 11: 59-61.Grimaudo, N. J. and Nesbitt, W. E. (1997). Oral Microbiol. Immunol. 12: 168-173.

 

Project Title:

Candida biofilms: molecular mechanisms and clinical implications

Investigator(s):

Samaranayake LP, Samaranayake YH, Jin LJ, Wang Y

Department:

Dental Faculty

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

12/2006

 

Abstract:

To compare the gene and protein expression, relevant to its virulent attributes, in sessile and palnktonic phase Candida on an inert surface and an epithelial surface; to evaluate the biofilm-associated drug resistance of C. albicans to three representative, commonly used, major antifungal agents: amphotericin B (polyene group), fluconazole (azole group) and capsofungin (echinocandin group); to characterize the effects of three innate mucosal defense constituents: lactoferrin, histatins and defensins on Candida biofilms.

 

List of Research Outputs

 

Dyson J.E., Yiu C.K.Y., Samaranayake L.P., Bridges S.M., Lane T., Chan J.P.S., Cheng S.W. and Leung R.T.C., Problem-based learning in dentistry. Hong Kong, Faculty of Dentistry, The University of Hong Kong, 2008.

 

Hagg E.U.O., Wong R.W.K., Samaranayake L.P., Kao R. and Yuen M., A Natural Edible Agent for Reduction of Oral Biofilm, IADR/GSK Innovation in Oral Care Awards. Awarded by IADR and GlaxoSmithKline Consumer Healthcare, 2 – 5 July, 2008 . 2008.

 

Hagg E.U.O., Wong R.W.K., Samaranayake L.P., Kao R. and Yuen M., A Natural Edible Agent for Reduction of Oral Biofilm, IADR/GSK Innovation in Oral Care Awards. External funding, US$ 75,000 unrestricted research grant. Awarded by IADR and GlaxoSmithKline Consumer Healthcare, 2 – 5 July, 2008. 2008.

 

Jayatilake J.A.M.S., Samaranayake Y.H. and Samaranayake L.P., A comparative studyof candidal invasion in rabbit tongue mucosal explants and reconstituted human oral epithelium, Mycopathologia. 2008, 165(6): 373-80.

 

Jin L.J., Lu Q., Samaranayake L.P. and Darveau R., P. gingivalis Lipopolysaccharide with different structures differentially modulates innate responses, Journal of Dental Research. 2007, 86 (Spec Iss B): IO-14.

 

Lee W., Low K...M..., Samaranayake L.P. and Hagg E.U.O., Genotypic variation of Candida albicans during orthodontic therapy, Frontiers in Bioscience. 2008, 13: 3814-3824.

 

Leung W.K., Siu S.C., Chu F.C.S., Wong K.W., Jin L.J., Sham A.S.K., Tsang P.C.S. and Samaranayake L.P., Oral health status of low-income, middle-aged to elderly Hong Kong Chinese with type 2 diabetes mellitus , Oral Health & Preventive Dentistry. 2008, 6: 105-118.

 

Lu Q., Jin L.J., Samaranayake L.P. and Darveau R.P., Outstanding Oral Presentation Award (Primary supervisor for Dr. Q. Lu, a postdoctorial fellow), 2nd International Conference on Evidence-based Advanced Dentistry, Hong Kong, China, 16-19 November 2007. 2007.

 

Lu Q., Samaranayake L.P., Darveau R.P. and Jin L.J., Outstanding Poster Presentation Award (Primary supervisor for Dr. Q. Lu, a postdoctorial fellow), Inaugural Conjoint Dental Scientific Meeting - The University of Hong Kong and Wuhan University, China, 10-11 May, 2008. 2008.

 

Lu Q., Jin L.J., Samaranayake L.P. and Darveau R., P. gingivalis lipopolysaccharides upregulate protease-activated receptor expression in gingival epithelium, Journal of Dental Research. 2007, 86 (Spec Iss B): IP-130.

 

Mendes A., Mores A.U., Carvalho A.P., Rosa R.T., Samaranayake L.P. and Rosa E.A.R., Candida albicans Biofilms Produce More Secreted Asparty Protease than the Planktonic Cells, Pharmaceutical Society Of Japan . 2007, 30(9): 1813-1815.

 

Perera R.A.P.M., Tsang P.C.S., Li P., Lee M.P., Samaranayake L.P. and McMillan A.S., Oral Manifestations of ethnic Chinese HIV-infected adults on HAART, Inaugural Conjoint Dedntal Scientific Meeting. The University of Hong Kong and Wuhan University 2008.. 2008.

 

Samaranayake L.P., Saliva as a diagnostic fluid, International Dental Journal. 2007, 57: 295-299.

 

Samaranayake Y.H., Samaranayake L.P., Cheung B.P.K., Parahitiyawa N.B., Yau J.Y.Y. and Yeung S.K.W., Synergistic Inhibition of Candida biofilms by Lysozyme and Common Antifungals , Inaugural Conjoint Dental Scientific Meeting. The University of Hong Kong and Wuhan University 2008.

 

Seneviratne C.J., Wang Y., Jin L.J. and Samaranayake L.P., A clue to drug resistance in Candida biofilm proteome?, Journal of Dental Research. 2007, 86 (Spec Iss B): IO-36.

 

Seneviratne C.J., Wong R.W.K. and Samaranayake L.P., Potent anti-microbial activity of traditional Chinese medicine herbs against Candida species, Mycoses. 2008, 51(1): 30-34.

 

Seneviratne C.J., Wang Y., Jin L.J., Abiko Y. and Samaranayake L.P., Candida albicans biofilm formation is associated with increased anti-oxidative capacities, Proteomics. 2008, 8(14): 2936-47.

 

Soysa N.S., Samaranayake L.P. and Ellepola A.N., Antimicrobials as a contributory factor in oral candidosis - a brief overview., Oral Diseases. 2008, 14(2): 138-143.

 

Thiele M.C., Carvalho A.D., Gursky L.C., Rosa R.T., Samaranayake L.P. and Rosa E.A., The role of candidal histolytic enzymes on denture-induced stomatitis in patients living in retirement homes, Gerodontology. 2008, 25: 1-8.

 

Tsang P.C.S., Chu F.C.S., Leung W.K., Jin L.J., Samaranayake L.P. and Siu S.C., Phospholipase, proteinase and haemolytic activities of Candida albicans isolated from oral cavities of patients with type 2 diabetes mellitus, Journal of Medical Microbiology. 2007, 56: 1393-1398.

 

Zaw M.T., Samaranayake Y.H. and Samaranayake L.P., Characteristics of dual species candida biofilms on denture acrylic surfaces, Archives of Oral Biology. 2007, 52: 1200-1208.

 

Zaw M.T., Samaranayake Y.H. and Samaranayake L.P., Dietary sugars, serum and the biocide chlorhexidine digluconate modify the population and structural dynamics of mixed Candida albicans and Escherichia coli biofilms, APMIS. 2007, 115: 1241-1251.

 

Zhu H., McMillan A.S., McGrath C.P.J., Li L.S.W. and Samaranayake L.P., Oral carriage of yeasts and coliforms in stroke sufferers: a prospective longitudinal study, Oral Diseases. 2008, 14(1): 60-66.

 

Researcher : Samaranayake YH

List of Research Outputs

 

Jayatilake J.A.M.S., Samaranayake Y.H. and Samaranayake L.P., A comparative studyof candidal invasion in rabbit tongue mucosal explants and reconstituted human oral epithelium, Mycopathologia. 2008, 165(6): 373-80.

 

Samaranayake Y.H., Samaranayake L.P., Cheung B.P.K., Parahitiyawa N.B., Yau J.Y.Y. and Yeung S.K.W., Synergistic Inhibition of Candida biofilms by Lysozyme and Common Antifungals , Inaugural Conjoint Dental Scientific Meeting. The University of Hong Kong and Wuhan University 2008.

 

Zaw M.T., Samaranayake Y.H. and Samaranayake L.P., Characteristics of dual species candida biofilms on denture acrylic surfaces, Archives of Oral Biology. 2007, 52: 1200-1208.

 

Zaw M.T., Samaranayake Y.H. and Samaranayake L.P., Dietary sugars, serum and the biocide chlorhexidine digluconate modify the population and structural dynamics of mixed Candida albicans and Escherichia coli biofilms, APMIS. 2007, 115: 1241-1251.

 

Researcher : Samman N

Project Title:

Distraction versus orthognathic surgery - which one is better for cleft palate patients?

Investigator(s):

Samman N, Cheung LK, Whitehill TL, Ho MY, Bendeus SAM, Chua HDP

Department:

Dental Faculty

Source(s) of Funding:

Competitive Earmarked Research Grants (CERG)

Start Date:

01/2006

 

Abstract:

To compare the clinical morbidity of distraction and orthognathic surgery in cleft palate Le Fort I osteotomy; to compare the skeletal and dental relapse of distraction and conventional Le Fort I osteotomy in 3 dimensions; to compare the speech and velopharyngeal function results of distraction and conventional Le Fort I osteotomy; to compare the psychological impact of cleft orthognathic surgery versus distraction osteogenesis in CLP patients.

 

List of Research Outputs

 

Choi W.S. and Samman N., Risks and benefits of deliberate hypotension in anaesthesia: a systematic review, Int J Oral Maxillofac Surg. 2008, 37: p 687-703.

 

Choi W.S., Irwin M.G. and Samman N., The effect of tranexamic acid on blood loss during orthognathic surgery: a randomized controlled trial, Inaugural Conjoint Dental Scientific Meeting, The University of Hong Kong and Wuhan University. 10-11 May, 2008, China. 2008, p. 41.

 

Lee S., McGrath C.P.J. and Samman N., Impact of orthognathic surgery on quality of life, J Oral Maxillofac Surg. 2008, 66: p. 1194-1199.

 

McGrath C.P.J., Pang H.H., Lo E.C.M., King N.M., Hagg E.U.O. and Samman N., Translation and evaluation of a Chinese version of the child oral health-related quality of life measure., Int J Paediatr Dent. 2008, 18: 267-274.

 

Samman N., Burden versus benefit analysis in cleft surgery - the burden is on us (invited lecture), 6th Asian Pacific Cleft Lip and Palate Congress. September 2007, Goa, India. 2007.

 

Samman N., Burden versus benefit analysis in cleft surgery - the burden is on us, 6th Asian Pacific Cleft Lip & Palate Congress, 2-5 September 2007, Goa, India. 2007, Abstract SPIC, abst book: p 60.

 

Samman N., Cleft Surgery: Ideals, Priority and Evidence (invited lecture), Mastering New Techniques in Maxillofacial Surgery & Implant Dentistry. October 2007, Hong Kong. 2007.

 

Samman N., Cleft Surgery: ideals, priority and evidence, Mastering New Techniques in Maxillofacial Surgery & Implant Dentistry. 14-18 October 2007, Hong Kong. 2007, Abstr book: p 10.

 

Samman N., Director, Cleft Lip and Palate Centre, University of Hong Kong. 2007.

 

Samman N., Early diagnosis of oropharyngeal cancer: recognition of risk factors and precancerous conditions, 2007 International and 9th National Head & Neck Tumour conference Urumqi, China, September. 2007.

 

Samman N., Editor in Chief (since 2000), Asian Journal of Oral and Maxillofacial Surgery. 2007.

 

Samman N., Effect of Globalistation on Maxillofacial Practice (keynote lecture), Annual Meeting, Dutch Society of Oral and Maxillofacial Surgery. November 2007, Rotterdam, The Netherlands. 2007.

 

Samman N., External Assessor (2006 - 2008), University of Malaya. 2007.

 

Samman N., External Examiner (2005, 2007), University of Malaya. 2007.

 

Samman N., HK West Cluster Medical Committee, Queen Mary Hospital Committees. 2007.

 

Samman N., Honorary Doctorate of Dental Sciences, Prince of Songkla University, Thailand. 2007.

 

Samman N., Immediate Past President (2006 - 2008), Asian Association of Oral and Maxillofacial Surgeons. 2008.

 

Samman N., International Advisory Board (2003-2007), China Journal of Oral and Maxillofacial Surgery. 2007.

 

Samman N., Member of the Editorial Board (since 1997), Chinese Journal of Oral and Maxillofacial Surgery. 2007.

 

Samman N., Member, Academic Advisory Board, 2007 International & 9th National Head and Neck Cancer Congress, Urumqi, China. 2007.

 

Samman N., Orthognathic Surgery and Management of Profile, National CME / workshop on Secondary Cleft Lip and Palate Chennai, India, September. 2007.

 

Samman N., Past President (2008-2010), Hong Kong Association of Oral and Maxillofacial Surgeons. 2008.

 

Samman N., President & Chairman, Board of Directors (2007 - 2009), International Association of Oral and Maxillofacial Surgeons. 2007.

 

Samman N., President (2007 - 2009), International Association of Oral and Maxillofacial Surgeons. 2007.

 

Samman N., Rhinoplasty in Cleft Lip and Palate - When and How? (invited lecture), International Cleft Palate Foundation Workshop. November 2007, Beijing, China. 2007.

 

Samman N., Rhinoplasty in Cleft Lip and Palate - When and How?, International Cleft Lip and Palate Foundation Workshop. 25-29 November 2007, Beijing, China. 2007, Abstr book: p 23-25.

 

Samman N., Secondary Cleft Lip and Palate Operations (invited lecture), 10th National Congress, Indonesian Association of Oral and Maxillofacial Surgeons. February 2008, Semarang, Indonesia. 2008.

 

Samman N., Section Chairman (Clinical Pathology) since 2001, International Journal of Oral and Maxillofacial Surgery. 2007.

 

Samman N., Skeletal Surgery in CLP - immediate advancement or gradual distraction? (invited lecture), 6th Asian Pacific Cleft Lip and Palate Congress. September 2007, Goa, India. 2007.

 

Samman N., Skeletal surgery in CLP - immediate advancement or gradual distraction, 6th Asian Pacific Cleft Lip & Palate Congress. 2-5 September 2007, Goa, India. 2007, Abstract SBIA, Abst book: p 102.

 

Samman N., Special Honorary Fellowship, American Association of Oral and Maxillofacial Surgeons. 2007.

 

Samman N., Speech after glossectomy (invited lecture), Asian Association of Oral and Maxillofacial Surgeons - Lectures & Workshop. June 2008, Bali, Indonesia. 2008.

 

Samman N., Speech after glossectomy - surgical implications, Asian Association of Oral and Maxillofacial Surgeons Lectures and Workshop. 28-29 June 2008, Bali, Indonesia. 2008, Abstr book: p 19-20.

 

Samman N., Speech after glossectomy, Asian Association of Oral and Maxillofacial Surgeons - Lectures & Workshop, Bali, Indonesia, June. 2008.

 

Samman N., The Face in Surgery and Art (invited lecture), Symposium on Face and Identity. 4th International Bernd-Spiessl-Symposium for Innovative and Visionary Technologies in Cranio-Maxillofacial Surgery. June 2008, Basel, Switzerland. 2008.

 

Researcher : Seneviratne CJ

List of Research Outputs

 

Seneviratne C.J., Wang Y., Jin L.J. and Samaranayake L.P., A clue to drug resistance in Candida biofilm proteome?, Journal of Dental Research. 2007, 86 (Spec Iss B): IO-36.

 

Seneviratne C.J., Wong R.W.K. and Samaranayake L.P., Potent anti-microbial activity of traditional Chinese medicine herbs against Candida species, Mycoses. 2008, 51(1): 30-34.

 

Seneviratne C.J., Wang Y., Jin L.J., Abiko Y. and Samaranayake L.P., Candida albicans biofilm formation is associated with increased anti-oxidative capacities, Proteomics. 2008, 8(14): 2936-47.

 

Researcher : Sham ASK

List of Research Outputs

 

Leung W.K., Siu S.C., Chu F.C.S., Wong K.W., Jin L.J., Sham A.S.K., Tsang P.C.S. and Samaranayake L.P., Oral health status of low-income, middle-aged to elderly Hong Kong Chinese with type 2 diabetes mellitus , Oral Health & Preventive Dentistry. 2008, 6: 105-118.

 

Researcher : Shi X

List of Research Outputs

 

Shi X., Reconstruction of ankylotic mandibular condyle by transport distraction osteogenesis, PhD Thesis. The University of Hong Kong, 2008.

 

Researcher : Shum IHY

List of Research Outputs

 

Shum I.H.Y., Jin L.J., Leung P.C., Lau E., Kwok A., Corbet E.F. and Orwoll E.S., Association of periodontal disease with osteoporosis/osteopenia in Chinese Men, Journal of Dental Research. 2007, 86 (Spec Iss B): IP-126.

 

Researcher : Siu SC

List of Research Outputs

 

Chu F.C.S., Deng F., Siu S.C. and Chow T.W., The use of immediate implant placement for the replacement of a periodontally involved malaligned lateral incisor: A clinical report. , Journal of Prosthetic Dentistry . 2007, 98: 423-428.

 

Researcher : Tang DYK

List of Research Outputs

 

Tsang P.C.S. and Tang D.Y.K., Candida albicans biofilms on titanium discs with different surface treatments., 21st IADR/18th SEAADE Annual Scientific Meeting 2007.

 

Researcher : Tay FRCM

List of Research Outputs

 

Dhanpal P.K., Yiu C.K.Y., King N.M., Tay F.R.C.M. and Hiraishi N., Effect of temperature on water sorption and solubility of dental adhesive resins, Second International Conference on Evidence-based Advanced Dentistry, Conjoint Congress 16-19 November, Hong Kong. 2007. P.68 Abstract P-26.

 

Hiraishi N., Yiu C.K.Y., King N.M., Tay F.R.C.M. and Pashley D.H., Chlorhexidine release and water sorption characterisitcs of chlorhexidine-incorporated hydrophobic/hydrophilic resins., Dent Materials. 2008, 24: 1391-9.

 

Hiraishi N., Yiu C.K.Y., King N.M., Tay F.R.C.M. and Pashley D.H., Chlorhexidine release and water sorption characteristics of chlorhexidine-incorporated dental adhesive resins, Second International Conference on Evidence-based Advanced Dentistry, Conjoint Congress 16-19 November, Hong Kong. 2007. P.71 P-30.

 

Hiraishi N., Yau J.Y., Loushine R.J., Armstrong S.R., Weller R.N., King N.M., Pashley D.H. and Tay F.R.C.M., Susceptibility of a polycaprolactone-based root canal filling material to degradation: III. Turbdimetric evaluation of enzymatic hydrolysis., J Endod. 2007, 33(8): 952-956.

 

Itthagarun A., Thaveesangpanich P., King N.M., Tay F.R.C.M. and Wefel J.S., Effects of different amounts of a low fluoride toothpaste on primary enamel lesion progression: a preliminary study using in vitro pH-cycling system. , Eur Arch Paediatr Dent. 2007, 8(1): 69-73.

 

Tay F.R.C.M., Pashley D.H., Loushine R.J., Kuttler S., Garcia-Godoy F., King N.M. and Ferrari M., Susceptibilityof a polycaprolactone-based root canal filling material to degradation. Evidence of biodegradation from a stimulated field test., Am J Dent. 2007, 20(6): 365-369.

 

Yiu C.K.Y., Hiraishi N., King N.M. and Tay F.R.C.M., Effect of pulpal pressure on bond strength of luting cements to dentin, Second International Conference on Evidence-based Advanced Dentistry, Conjoint Congress 16-19 November, Hong Kong. 2007. P.38 O-17.

 

Researcher : Tideman H

Project Title:

Functional reconstruction of the upper jaw

Investigator(s):

Tideman H, Luk WK

Department:

Dental Faculty

Source(s) of Funding:

Other Funding Scheme

Start Date:

01/1992

 

Abstract:

To restore the function of the upper jaw after ablative surgery with bone and implants.

 

Project Title:

Functional reconstruction of the lower jaw

Investigator(s):

Tideman H, Luk WK

Department:

Dental Faculty

Source(s) of Funding:

Other Funding Scheme

Start Date:

01/1994

 

Abstract:

To restore the function of the lower jaw after ablative surgery with bone and implants.

 

List of Research Outputs

 

Researcher : Tong KSK

List of Research Outputs

 

Tong K.S.K. and Corbet E.F., Periodontal referral in Hong Kong, Hong Kong Dental Journal. 2008, 5: 19-26.

 

Researcher : Torroni A

List of Research Outputs

 

Torroni A., Gennaro P., Aboh I.V., Longo G., Valentini V. and Iannetti G., Microvascular reconstruction of the mandible in irradiated patients, The Journal of Craniofacial Surgery. 2007, 18 (6): p. 1359 - 69.

 

Torroni A., Gennaro P., Nicolai G., Lorè B., Valentini V. and Iannetti G., Reconstruction of premaxilla with fibula free flap, The Journal of Craniofacial Surgery. 2007, 18 (6): p 1385-94.

 

Torroni A., Lorè B. and Iannetti G., The importance of the head and neck region in regression of advanced MCC: a clinical report, The Journal of Craniofacial Surgery. 2007, 18 (5): p 1173-76.

 

Researcher : Tsang PCS

Project Title:

Clinical, microbiological and histopathological study of oral diseases in renal transplant patients in Hong Kong

Investigator(s):

Tsang PCS, Leung WK, Samaranayake LP, Chan AWK, Chan DTM, Chu FCS

Department:

Dental Faculty

Source(s) of Funding:

Other Funding Scheme

Start Date:

03/2000

 

Abstract:

To obtain baseline data on the oral health in a group of renal transplant patients; to compare the effects of cyclosporin A ad FK506 on oral tissues and oral mciroflora; to investigate the effects of oral health programme on the oral status of these patients, both clinically and microbiologically.

 

Project Title:

Effect of highly active antiretroviral therapy on oral candidiasis in human immunodeficiency virus-infected individuals in Hong Kong

Investigator(s):

Tsang PCS

Department:

Dental Faculty

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

02/2005

 

Abstract:

Purpose: To investigate the effects of HAART on the oral health of HIV-infected individuals in Hong Kong. Key issues: Before the introduction of HAART in the management of HIV-infected individuals, opportunistic infections were common in this patient group. With the increasing use of HAART, which usually includes a protease inhibitor, the incidence of opportunistic infection has markedly decreased. Though a number of hypotheses had been proposed to explain this phenomenon, the actual mechanism is still unknown. Evidence is there that HAART exerts its effect by increasing the circulating CD4+ T cells, cellular and/or humoral responses. However, some surmise that protease inhibitors may have a direct anti-candidal effect, targeting the secreted aspartyl proteinases (Saps), an essential virulence attribute for mucosal infestation by C. albicans. The major aims of the study are; 1. To obtain data on the incidence and prevalence of oral manifestations of HIV infection by a prospective screening programme of 60 patients under HAART with regards to their oral health. Once these parameters are noted they would be correlated with immunological indices such as CD4+ T cells count and viral load. (Hypothesis: there is a decrease in the prevalence and incidence of oral manifestations of HIV-infected individual under HAART) 2. To study the oral yeast using ‘concentrated oral rinse cultures’ to determine how the use of HAART with and without protease inhibitors can affect the oral carriage rates of Candida species in HIV-infected individuals. (Hypothesis: the oral carriage rate of C. albicans in HIV-infected individuals is decreased by the use of protease inhibitors) 3. To determine C. albicans SAP1 SAP8 gene expression during oral infection and colonization in vivo and the effects of different protease inhibitors on the C. albicans SAP1 SAP8 gene expression. Results thus obtained may assist in the choice and dosage of protease inhibitors when treating these patients. (Hypothesis: SAP gene family are temporally regulated and expressed during candidal infection) 4. To determine the effects of different protease inhibitors on the adherence of C.albicans to buccal epithelial cells, which allow us to have a better understanding in the pathogenesis of oral candidal infection in HIV infection. (Hypothesis: Adherence of C. albicans to buccal epithelial cells is decreased by the presence of protease inhibitors) 5. Finally, the above data is to be collated to produce recommendations, which will improve the maintenance of oral health and hence the general health of HIV-infected individuals in Hong Kong. We are confident that the proposed studies could be successfully completed due to the expertise of the investigators. As far as we are aware, the proposed studies are pioneering investigations on HIV-infections in the South-East Asian region. Hence the data from the study should be of value not only for Hong Kong but also for the South East Asia for investigators in this field. Pending the outcome of the proposed studies, it is our intention to initiate collaborative studies with oral microbiologists and pathologists in neighbouring Asian countries.

 

Project Title:

Effect of different protease inhibitors on Candida albicans SAP1- SAP10 gene expression.

Investigator(s):

Tsang PCS, McMillan AS

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2006

 

Abstract:

Purpose: To investigate the effects of Highly Active Antiretroviral Therapy (HAART) on C. albicans SAP-SAP gene expression in the presence of protease inhibitors. Key issues: Before the introduction of HAART in the management of HIV-infected individuals, opportunistic infections were common in this patient group. With the increasing use of HAART, which usually includes a protease inhibitor, the incidence of opportunistic infection has markedly decreased. Though a number of hypotheses had been proposed to explain this phenomenon, the actual mechanism is still unknown. Evidence is there that HAART exerts its effect by increasing circulating CD4+ T cells, cellular and/or humoral responses. However, some surmise that protease inhibitors may have a direct anti-candidal effect, targeting the secreted aspartyl proteinases (Saps), an essential virulence attribute for mucosal infestation by C. albicans. The major aims of the study are: 1. To determine C. albicans SAP1 SAP10 gene expression during oral infection and colonization in vitro , 2. To determin the effects of different protease inhibitors on the C. albicans SAP1- SAP10 gene expression. Results thus obtained may assist in the choice and dosage of protease inhibitors when treating these patients. (Hypothesis: SAP gene family are temporally regulated and expressed during candidal infection)

 

List of Research Outputs

 

Leung W.K., Siu S.C., Chu F.C.S., Wong K.W., Jin L.J., Sham A.S.K., Tsang P.C.S. and Samaranayake L.P., Oral health status of low-income, middle-aged to elderly Hong Kong Chinese with type 2 diabetes mellitus , Oral Health & Preventive Dentistry. 2008, 6: 105-118.

 

Perera R.A.P.M., Tsang P.C.S., Li P., Lee M.P., Samaranayake L.P. and McMillan A.S., Oral Manifestations of ethnic Chinese HIV-infected adults on HAART, Inaugural Conjoint Dedntal Scientific Meeting. The University of Hong Kong and Wuhan University 2008.. 2008.

 

Tsang P.C.S., Ng H. and McMillan A.S., Antifungal susceptibility of Candida albicans biofilms on titanium discs with different surface roughness, Clinical Oral Investigations. 2007, 11(4): 361-8.

 

Tsang P.C.S. and Tang D.Y.K., Candida albicans biofilms on titanium discs with different surface treatments., 21st IADR/18th SEAADE Annual Scientific Meeting 2007.

 

Tsang P.C.S., Chu F.C.S., Leung W.K., Jin L.J., Samaranayake L.P. and Siu S.C., Phospholipase, proteinase and haemolytic activities of Candida albicans isolated from oral cavities of patients with type 2 diabetes mellitus, Journal of Medical Microbiology. 2007, 56: 1393-1398.

 

Tsang P.C.S. and Hong I., Protease Inhibitors Attenuate Adherence of Candida albicans to Acrylic Protease Inhibitors Attenuate Adherence of Candida albicans to Acrylic Surface , Journal of Dental Research. 2008, 87.

 

Researcher : Tse OD

List of Research Outputs

 

Tse O.D., Jin L.J. and Corbet E.F., Treatment of periodontitis and CRP serum level in Chinese adults, Journal of Dental Research. 2007, 86 (Spec Iss B): IP-143.

 

Researcher : Wang CY

List of Research Outputs

 

Jin L.J. and Wang C.Y., An update on periodontal infections, systemic inflammatory biomarkers, and cardiovascular disease, Chinese Journal of Dental Research. 2007, 10: 7-13.

 

Researcher : Wang Y

List of Research Outputs

 

Seneviratne C.J., Wang Y., Jin L.J. and Samaranayake L.P., A clue to drug resistance in Candida biofilm proteome?, Journal of Dental Research. 2007, 86 (Spec Iss B): IO-36.

 

Researcher : Watt RM

Project Title:

New Chemical Proteomics Methods For Selective Protein Capture And Identification

Investigator(s):

Watt RM, Che CM

Department:

Chemistry

Source(s) of Funding:

Small Project Funding

Start Date:

09/2005

 

Abstract:

Chemical proteomics (sometimes referred to as chemistry-based functional proteomics) is an extremely new and exciting area within the chemical biology field. It is broadly defined as being the integration of protein biochemistry and organic chemistry to study protein function on a genome wide scale. The main aims of chemical proteomics are to directly identify, quantify and characterize the ultimate products of genes, i.e. proteins: the bio-molecules that are the main effectors of activity within the cell. This is essential for a true and intimate understanding of cellular biology and function - one that cannot be gleamed solely from genetic or transcription-based analyses.Thus far, most of the research in chemical proteomics has centered on the design and synthesis of small chemical molecules that covalently label target proteins, enabling them to be subsequently identified and/or purified. These chemical probes are designed in such a way as to selectively modify certain classes of proteins, based upon mechanistic similarities (e.g. a shared active-site topography) or due to the nature or arrangement of their component amino acid residues. Aspects of this technology are related to two approaches commonly used in medicinal chemistry, for the identification of possible protein targets of drugs or other bio-molecules within the cell. In the first of these approaches, the drug (or an analogue of it) is linked to a resin or bead, which is used to capture interacting protein species from a cell-free extract. These are subsequently identified by mass spectrometry, protein sequencing or antibody-based methods. In the second approach, a radio- or fluorescently- labeled analogue of the drug or enzyme substrate is used to covalently modify the target protein, which is subsequently purified and identified.Thomas Kodadek (University of Texas Southwest Medical Center), Benjamin Cravatt (Scripps Institute, Skaggs Institute for Chemical Biology) and Matthew Bogyo (Celera Genomics and Stanford University) have conducted some innovative research in this field, developing a number of small chemical affinity probes to target classes of proteins that include proteases, hydrolases and phosphatases. They have outlined two main approaches: a) activity-based probes, and b) affinity-based probes. Activity-based chemical probes may be thought of as being analogous to mechanism-based or suicide inhibitors, in that they irreversibly label proteins directly as a result of their catalytic activities. Affinity-based probes may be thought of as being more general protein labeling agents, not directly linked to protein activity. These reagents do not necessarily target active sites residues, but still bind tightly to specific families of proteins, covalently modifying them. In addition, there are non-specific protein labeling reagents that chemically modify a broad range of proteins, usually targeting specific residues e.g. cysteine thiols or lysine amines.In this proposal, I will take a slightly different approach. I will synthesize a novel set of chemical affinity probes to target families of essential and ubiquitous metabolic and biosynthetic proteins/enzymes. The chemical affinity probes will contain a 'reactive' moiety that will be the main determinant for the types of proteins targeted, as well as a component that will enable subsequent affinity-based protein purification or localization on 2D gels by fluorimetry. Two main types of affinity probes will be synthesized: Highly selective probes targeting functionally-related protein families Less functionally-selective probes, targeting a broader range of proteinsStructurally simple reactive homologues of intermediates in common biosynthetic pathways will be used as components of the probes with a more general selectivity. The rationale behind this being that many of these intermediates are shared between different pathways (which are generally highly conserved between organisms), and they form the structural basis of numerous bioactive compounds. Choosing these types of compound maximizes the likelihood of finding chemical affinity probes of broad applicability. These chemical molecules will be designed to bind irreversibly to families of proteins within cells, in a cell or tissue extract (e.g. mouse liver extract, bacterial cell lysate, etc.) or in a biological fluid sample (e.g. plasma, plant sap, etc.).I will focus on (P450-type) oxidases; intermediates of fatty-acid and polyketide biosynthesis; amino acid and small-molecule biosynthesis and metabolism. Established mechanism-based enzyme inactivators will be used along with other simple drug and biosynthetic compound analogues. Synthetic strategies will be kept deliberately straightforward, maximizing the time spent on optimizing the protein labeling chemistry and experimental conditions, etc. I will consciously use compounds that will be relatively non-specific in nature to maximize the potential for serendipitous discovery.

 

Project Title:

The identification and characterization of new bacterial protein targets for inhibition - determining their potential for antibiotic development

Investigator(s):

Watt RM

Department:

Chemistry

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

08/2006

 

Abstract:

As a newly appointed RAP within the chemistry department, I would like to establish a new area of research focused on the study of essential bacterial proteins, with a view to discovering new antibiotic compounds, and new targets for antibacterial chemotherapy. There are two main research objectives in this Seed Funding proposal: 1) To biochemically characterize several putatively essential bacterial proteins, and identify at least two that will be amenable to subsequent high throughput inhibitor screening 2) To purify the ‘native’ complexes formed by a number of these essential proteins within their natural host using a newly developed ‘tandem affinity’ (TAP) tag procedure, for subsequent analysis by mass spectrometry After reviewing the literature, and performing various bioinformatic analyses of sequenced bacterial genomes, a number of candidate proteins have been identified for detailed investigation (see below). These proteins are all essential or putatively essential, and fall within three specific functional categories. I have focused on proteins from a variety of bacterial species that are either model organisms, or are medically important pathogens. This will enable the functions of different family members (homologues) to be compared and contrasted, hopefully allowing some important general conclusions to be drawn after the completion of the experiments. The 3 areas I will focus on are: Polyphosphate and pyrophosphate degradation A small family of GTPases of poorly defined or unknown function The last two steps of the methylerythriyol phosphate (MEP) biosynthetic pathway All organisms have at least one inorganic pyrophosphatase, which catalyzes the breakdown of pyrophosphate (diphosphate) to two phosphate (orthophosphate) molecules. The very high free energy for this process is the driving force for many thermodynamically unfavourable biochemical reactions. Consequently, the activity of this enzyme activity is essential in all known organisms. Certain bacteria appear to have two types of pyrophosphatase: one that preferentially uses magnesium as a cofactor (type A, Ppa), and another that prefers manganese or cobalt (Family II, or type C, PpaC). Mutagenesis studies in a number of organisms have shown that both genes are essential, which suggests that the two proteins have non-overlapping or non-complementary functions. The PpaC family of pyrophosphatases may also play a role in the degradation of polyphosphate (long chain phosphate), which is an enigmatic intracellular molecule, with a poorly defined function. Polyphosphate is thought to be involved in metal transport, metal sequestration and the stress response, amongst many other processes. I have identified a putative type C pyrophosphatase in Mycobacterium tuberculosis (the causative agent of tuberculosis), as well as another gene that may encode an additional exopolyphosphatase (which degrades polyphosphate) or possibly even a guanosine tetraphosphatase (ppGpp) hydrolase (a protein that degrades an important nucleotide-phosphate signaling molecule). Consequently, I will clone, express and characterize the biochemical and biophysical properties of these two proteins, to investigate this hypothesis. Furthermore, as both genes are essential, I will determine whether it will be possible to develop biochemical assays that will be suitable for use in high throughput inhibition studies (with a commercial library of compounds, to be performed at a later date). Finding specific inhibitors for these two classes of bacterial enzymes is especially attractive, as there are no homologues in higher organisms. Within bacteria, there is a family of essential and highly conserved bacterial GTPase proteins, whose activities are currently poorly understood. The family comprises the following genes: era (bex), engA (der, yfgK), engB (yihA), engD (obg, yhcf), trmE (thdF), hflX, ftsY, obgE (ctgA, yhbZ), and ffh. However, there may be redundancy or some overlapping of activities within this family, as some bacteria do not appear to have all of them (they generally have between 5 to 8 members). I have already cloned a number of these genes from Pseudomonas aeruginosa and Staphylococcus aureus (opportunistic pathogens), vibrio cholerae (the causative agent of cholera) and E. coli (a model bacterium, that is sometimes pathogenic). For this proposal, I plan to investigate their NTPase (nucleotide and deoxynucleotide triphosphatase) activities, specifically regarding its stimulation upon RNA or DNA binding. I will also try to identify interacting protein species within the cell, using a TAP tag. If the NTPase activity is high enough, then it may be possible to design assays amenable to high throughput inhibitor screening. Until recently, it was thought that all organisms synthesized isopentenyl pyrophosphate (IPP) and dimethylallyl pyrophosphate (DMAPP), key metabolites in isoprenoid biosynthesis, via the same route: the mevalonate pathway. However, less than 10 years ago, several researchers showed that in most bacteria, some parasites, and in the chloroplasts of plants, that this was not the case. Subsequently the 7-step methylerythritol phosphate (MEP) pathway was gradually elucidated. As the synthesis of IPP and DMAPP is essential in all organisms, this makes the MEP pathway an excellent target for the development of selective antibiotic, anti-parasitic or herbicidal agents. The first 5 steps of the MEP pathway are well understood, but the mechanisms of the last two steps, catalyzed by the GcpE and LytB proteins respectively, remain to be fully established. Both of these enzymes require auxiliary redox proteins for activity. Working in collaboration with a research team in France, I plan to identify these redox proteins in E.coli, Pseudomonas aeruginosa and in the model plant Arabidopsis thaliana. I plan to use my recently developed TAP tag to do this. The French collaborators will work on other aspects of the chemical processes. The three areas of research described above will all utilize similar methodology, reagents and equipment, and are thus partially overlapping. I will focus most of my initial efforts on characterizing the two putative mycobacterial phosphatases, but also envisage fairly rapid progress to be made in the two other areas.

 

Project Title:

Isoprenoid biosynthesis via the methylerythritoal phosphate (MEP) pathway: proteomic analysis and identification of targets for inhibition

Investigator(s):

Watt RM

Department:

Chemistry

Source(s) of Funding:

France/Hong Kong Joint Research Scheme - Travel Grants

Start Date:

01/2007

 

Abstract:

1. Identify the protein complexes (specifically, the accessory redox proteins) that are involved in the final two steps of the essential methylerythritol phosphate (MEP) biosynthetic pathway in a number of plant and medically-important bacterial species. 2. Compare and contrast experimental results with literature data. Thoroughly investigate any potential differences that may exist in the nature of the putative accessary protein complexes used in the various plant and bacterial species (i.e. are there different mechanisms for protein reduction/oxidation?). 3.Evaluate overall project findings, and formulate strategies for future research directions. Identify candidate proteins as possible targets for inhibition, with a view to the development of potential biocide (antibacterial, herbicide) agents.

 

List of Research Outputs

 

Watt R.M., Huang J., Ho J.W.S. and Chen W., Engineering Bacterial Chromosomes: E. coli and Beyond, Hong Kong-Wuhan University Conjoint Scientific Meeting, Dongguan, China, 10-11th May. 2008.

 

Zhou J., Huang J., Poon K.M., Chen D., Chan C.S., Ng F., Guan X.Y., Watt R.M., Lu L., Yuen K.Y. and Zheng B., A mechanism underlying susceptibility to HBV infection: HBV down-regulate transferase-1 type I interferon receptor 1 via suppressing poly(ADP-ribose), 2007 International Meeting: The Molecular Biology of Hepatitis B Viruses.. 2007.

 

Researcher : Wong AHH

List of Research Outputs

 

Lo E.C.M., Wong A.H.H. and McGrath C.P.J., A randomized controlled trial of home tooth-whitening products, American Journal of Dentistry. 2007, 20: 315-318.

 

Wong A.H.H., Lo E.C.M., Chu C.H. and Lin H.C., Two minimally invasive treatments for decayed primary molars - 24-month results, Journal of Dental Research. 2007, 86 (Spec Iss B): IP-013.

 

Researcher : Wong AWY

List of Research Outputs

 

Chu C.H., Wong A.W.Y., Lo E.C.M. and Courtel F., Oral health status and behaviours of children in rural districts of Cambodia, International Dental Journal. 2008, 58: 15-22.

 

Researcher : Wong CM

Project Title:

Chronic Oro-facial Pain and Need for Treatment among Older Chinese Adults

Investigator(s):

Wong MCM, McMillan AS

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2005

 

Abstract:

The aim of this study is to investigate chronic oro-facial pain and need for treatment among older Chinese adults in Hong Kong.Objectives: 1) to study the severity of chronic oro-facial pain, the disability related to and treatment seeking behaviour for the condition among older Chinese adults and; 2) to study associations and disparities between the severity of chronic oro-facial pain, disability and treatment seeking .Chronic pain is a common and disabling condition, with a high impact on health and the health services in the community (Smith et al. 2001). According to the International Association for the Study of Pain (IASP), chronic pain is defined as pain that persists beyond normal tissue healing time, which in the absence of any other rigorous criteria, is accepted as three months (IASP, 1986). Oro-facial pain can be defined as pain related to the face and/or mouth. Many of these regional pains present a recurrent, persistent, and disabling pattern because of the complex regional anatomy of the face and mouth region, and there are often difficulties in the diagnosis and treatment of chronic oro-facial pain conditions (Chung et al. 2004). The average life expectancy has increased because of the great social and medical achievements, and the proportion of the aged in the population is increasing rapidly in most developed countries including Hong Kong. Degenerative changes in the oro-facial tissue and oro-facial pain are cumulative across the life span, which means that disability and chronic pain are generally maximized among the elderly. Older adults may be vulnerable to chronic oro-facial pain because of the aging process, their oral health status, and social circumstances. The elderly are frequently socially disadvantaged, and pain symptoms in general are more prevalent in those people least able to seek care and attention (Riley et al, 2002). In addition, a key feature of chronic oro-facial pain conditions is that individuals with the same chronic oro-facial pain may respond differently in their need for treatment and ability and desire to obtain professional advice. Thus it is very important to understand the associations and disparities between chronic oro-facial pain and treatment seeking behaviour.Chung JW, Kim JH, Kim JD et al. (2004). Chronic orofacial pain among Korean elders: prevalence, and impact using the graded chronic pain scale. Pain 112:164-170.International Association for the Study of Pain (1986). Classification of chronic pain. Pain (Suppl. 3):S1-S226.Riley JL, Gilbert GH, Heft MW. Race/ethnic differences in health care use for orofacial pain among older adults. Pain 2002;100:119-130.Smith BH, Penny KI, Elliott AM et al. (2001). The Level of Expressed Need - a measure of help-seeking behaviour for chronic pain in the community. European Journal of Pain 5:257-266.

 

Project Title:

Expectation of oral health among older Chinese adults in Hong Kong

Investigator(s):

Wong MCM, Lo ECM, McGrath CPJ

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2006

 

Abstract:

Studies on the relationship between people's expectation and their behaviour have been carried out for many years in psychology but little has been done in dentistry. The decision about whether one needed dental treatment could possibly be affected by the extent of dental problems they expected to encounter and whether they perceive a better oral health-related quality of life (OHQoL) after the treatment. Therefore, the expectation of oral health and OHQoL before dental treatment can be an important factor in determining the perceived need for dental treatment. The aim of this study is to explore, develop and evaluate the performance of a measure of oral health expectation among older Chinese adults in Hong Kong. Objectives: 1) To develope a geriatric oral health expectation index (GOHEI) and 2) To evaluate the performance of GOHEI in terms of feasibility, validity and reliability.

 

List of Research Outputs

 

Researcher : Wong HM

List of Research Outputs

 

King N.M., Tongkoom S., Itthagarun A., Wong H.M. and Lee C.K., A catalogue of anomalies and traits of the primary dentition of Southern Chinese., Journal of Clinical Pediatric Dentistry. 2007, 32(2): 139-146.

 

Lai M.C., King N.M. and Wong H.M., Dental development of Chinese children with cleft lip and palate, The Cleft Palate-Craniofacial Journal. 2008, 45(3): 289-296.

 

Wong H.M. and King N.M., Dental trauma management awareness of kindergarten teachers in Hong Kong, XV World Congress on Dental Traumatology. 2008.

 

Wong H.M. and King N.M., Knowledge of dental trauma management: an interview of 100 kindergarten teachers, Second International Conference on Evidence-based Advanced Dentistry. 2007.

 

Researcher : Wong JW

List of Research Outputs

 

Bridges S.M., Dyson J.E., Botelho M.G., Corbet E.F. and Wong J.W., Online Resourcing for Problem-based Curricula: The HKU Faculty of Dentistry Approach, Workshop, Transforming learning through technology @HKU, Centre for Information Technology in Education (CITE) Symposium, The University of Hong Kong.. Hong Kong, 2008.

 

Researcher : Wong KL

List of Research Outputs

 

Wong M.C.M., Lui K.C., Chan M.H., Cheng G.W.K., Cheung A.W.T., Cheung G.J.K., Fung P.L., Fung S.L., Lam Y.H., Mui N.H.T., Wong K.L. and Wong K.Y., Oral health care for inmates of rehabilitation centres in Hong Kong, Community Health Project Report Series. Faculty of Dentistry, The University of Hong Kong, 2008, 152: 1-50.

 

Researcher : Wong MCM

Project Title:

Chronic Oro-facial Pain and Need for Treatment among Older Chinese Adults

Investigator(s):

Wong MCM, McMillan AS

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2005

 

Abstract:

The aim of this study is to investigate chronic oro-facial pain and need for treatment among older Chinese adults in Hong Kong.Objectives: 1) to study the severity of chronic oro-facial pain, the disability related to and treatment seeking behaviour for the condition among older Chinese adults and; 2) to study associations and disparities between the severity of chronic oro-facial pain, disability and treatment seeking .Chronic pain is a common and disabling condition, with a high impact on health and the health services in the community (Smith et al. 2001). According to the International Association for the Study of Pain (IASP), chronic pain is defined as pain that persists beyond normal tissue healing time, which in the absence of any other rigorous criteria, is accepted as three months (IASP, 1986). Oro-facial pain can be defined as pain related to the face and/or mouth. Many of these regional pains present a recurrent, persistent, and disabling pattern because of the complex regional anatomy of the face and mouth region, and there are often difficulties in the diagnosis and treatment of chronic oro-facial pain conditions (Chung et al. 2004). The average life expectancy has increased because of the great social and medical achievements, and the proportion of the aged in the population is increasing rapidly in most developed countries including Hong Kong. Degenerative changes in the oro-facial tissue and oro-facial pain are cumulative across the life span, which means that disability and chronic pain are generally maximized among the elderly. Older adults may be vulnerable to chronic oro-facial pain because of the aging process, their oral health status, and social circumstances. The elderly are frequently socially disadvantaged, and pain symptoms in general are more prevalent in those people least able to seek care and attention (Riley et al, 2002). In addition, a key feature of chronic oro-facial pain conditions is that individuals with the same chronic oro-facial pain may respond differently in their need for treatment and ability and desire to obtain professional advice. Thus it is very important to understand the associations and disparities between chronic oro-facial pain and treatment seeking behaviour.Chung JW, Kim JH, Kim JD et al. (2004). Chronic orofacial pain among Korean elders: prevalence, and impact using the graded chronic pain scale. Pain 112:164-170.International Association for the Study of Pain (1986). Classification of chronic pain. Pain (Suppl. 3):S1-S226.Riley JL, Gilbert GH, Heft MW. Race/ethnic differences in health care use for orofacial pain among older adults. Pain 2002;100:119-130.Smith BH, Penny KI, Elliott AM et al. (2001). The Level of Expressed Need - a measure of help-seeking behaviour for chronic pain in the community. European Journal of Pain 5:257-266.

 

Project Title:

Expectation of oral health among older Chinese adults in Hong Kong

Investigator(s):

Wong MCM, Lo ECM, McGrath CPJ

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2006

 

Abstract:

Studies on the relationship between people's expectation and their behaviour have been carried out for many years in psychology but little has been done in dentistry. The decision about whether one needed dental treatment could possibly be affected by the extent of dental problems they expected to encounter and whether they perceive a better oral health-related quality of life (OHQoL) after the treatment. Therefore, the expectation of oral health and OHQoL before dental treatment can be an important factor in determining the perceived need for dental treatment. The aim of this study is to explore, develop and evaluate the performance of a measure of oral health expectation among older Chinese adults in Hong Kong. Objectives: 1) To develope a geriatric oral health expectation index (GOHEI) and 2) To evaluate the performance of GOHEI in terms of feasibility, validity and reliability.

 

List of Research Outputs

 

Hon A.K., Choi B.S.K., Siu E.K.S., You D.S.H. and Wong M.C.M., Attitudes towards advertising in dentistry in Hong Kong, Journal of Dental Research. 2007, 86 (Spec Iss B): IO-24.

 

Lau A.W.H., Wong M.C.M., Lam K.F. and McGrath C.P.J., Evaluation of child perceptions questionnaire (CPQ11-14) using structural equation modeling, Journal of Dental Research. 2007, 86 (Spec Iss B): IO-21.

 

Lee L.T.K., Yeung R.W.K., Wong M.C.M. and McMillan A.S., Diagnostic sub-types, psychological distress and psychosocial dysfunction in southern Chinese people with temporomandibular disorders, Journal of Oral Rehabilitation. 2008, 35(3): 184-90.

 

Leung K.C.M., McMillan A.S., Wong M.C.M., Leung W.K., Mok T.M.Y. and Lau C.S., The efficacy of cevimeline hydrochloride in the treatment of xerostomia in Sjögren's syndrome in southern Chinese patients: a randomised double-blind, placebo-controlled crossover study, Clinical Rheumatology. 2008, 27: 429-436.

 

Wong M.C.M., Advisory Board, Community Dentistry and Oral Epidemiology. Blackwell Munksgaard, 2007.

 

Wong M.C.M., Associate Editor, Community Dentistry and Oral Epidemiology. Wiley-Blackwell, 2008.

 

Wong M.C.M., Lau A.W.H., Lam K.F. and McGrath C.P.J., Construct validity of the short forms child perceptions questionnaire (CPQ11-14), Journal of Dental Research. 2007, 86 (Spec Iss B): IO-22.

 

Wong M.C.M., Cheung H.N., Fong T.S., Lau M.C., Mak R.L.Y., Man W.C., So M.K., Tai T.C., Yee Y.Y. and Yuen H.C., Health care vouchers for the elderly and utilization of dental services, Community Health Project Report Series. Faculty of Dentistry, The University of Hong Kong, 2008, 155: 1-39.

 

Wong M.C.M., Lui K.C., Chan M.H., Cheng G.W.K., Cheung A.W.T., Cheung G.J.K., Fung P.L., Fung S.L., Lam Y.H., Mui N.H.T., Wong K.L. and Wong K.Y., Oral health care for inmates of rehabilitation centres in Hong Kong, Community Health Project Report Series. Faculty of Dentistry, The University of Hong Kong, 2008, 152: 1-50.

 

Wong M.C.M., Semi-parametric multilevel random effects model with time-yarying regression coefficients for correlated grouped survival data, Cochrane Oral Health Group. 2007.

 

Researcher : Wong RMS

List of Research Outputs

 

Wong R.M.S., Ng S.K.S., Corbet E.F. and Leung W.K., Oral health-related quality of life changes upon non-surgical periodontal therapy, Journal of Dental Research. 2007, 86 (Spec Iss B): IP-139.

 

Researcher : Wong RWK

Project Title:

Bone induction using Naringin

Investigator(s):

Wong RWK, Rabie ABM

Department:

Dental Faculty

Source(s) of Funding:

Seed Funding Programme for Basic Research

Start Date:

10/2004

 

Abstract:

To investigate the use of Naringin on bone induction.

 

Project Title:

Cellular and molecular responses of mouse cranial bases (synchondroses) in mechanical stress.

Investigator(s):

Wong RWK, Rabie ABM

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

01/2006

 

Abstract:

To investigate the cellular and molecular responses of mouse craninal bases (synchondroses) in mechanical stress in organ culture.

 

Project Title:

The use of Genistin in bone induction

Investigator(s):

Wong RWK, Rabie ABM

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

01/2007

 

Abstract:

Objective:Bone induction is used to replace bone lost due to trauma, tumours and other pathological diseases. Over the years autogenous cancellous bone grafting has been considered the gold standard in this form of treatment. The major limitations of using autogenous grafting are the inadequacy of supply and surgical morbidity; including donor site pain, paraesthesia, and infection, which can approach 8% to 10% (Younger and Chapman 1989). Moreover, graft resorption poses a severe problem. In an experimental study, endochondral bone grafts showed 65% volume loss (Zins and Whitaker 1983). Allografts, an alternative to autogenous grafting, seem to be biologically inferior and are associated with infection and inflammation (Strong et al. 1996). Therefore, the search of an ideal bone grafting material that induces bone is an important issue in bone research. Bone morphogenetic proteins (BMPs) are important regulators in bone formation (Sakou 1998). Mundy et al. (1999) demonstrated that statin, a hydroxymethylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, specifically increased expression of the BMP-2 gene. We showed that statin increased new bone formation by more than 300% in vivo (Wong and Rabie 2003). Unfortunately, statin also has some side effects, including weakness, headache and on occasion serious muscle problems (Sifton, 2000), making the search for an ideal bone inductive agent still a necessity.Further studies have shown that this BMP-2 activation was a result of enzyme inhibition (Sugiyama et al. 2000). Therefore, it is possible that any drug that inhibits the HMG-CoA reductase may have a similar effect to statin in the activation of BMP-2.Genistin is a flavonoid found in the Chinese Medicine Ge Gen (Puerariae radix), the herb which has been shown to increase bone density (Wang et al. 2003). Our pilot study did shown that Ge Gen extract in a collagen carrier induced bone when grafted in a bone defect in rabbits. It is also commonly found in soybeans and soy foods such as tofu and light sauce. Studies have been made of its estrogenic, anti-osteoporotic, antioxidant, anticarcinogenic and anticholesterol effect. It has also been shown to have a HMG-CoA reductase inhibiting effect (Sung et al. 2004). It is therefore possible that Genistin may also activate BMP-2 and increase bone formation. To examine further the role of Genistin in clinical use for the repair of bone defects, it is important to examine its osteoinductivity in the presence of a carrier and to examine its healing route in an in vivo study.Aims:o To test the hypothesis that Genistin is effective for bone induction.o To examine the ability of Genistin with a carrier in bone induction by quantitatively assessing the amount of new bone formation with and without Genistin. o To identify the action mode and effects of Genistin on the gene expression profile in a Genistin -treated osteoblastic cell line cultured in vitro using molecular biology techniques.

 

List of Research Outputs

 

Al Khal H.A., Wong R.W.K. and Rabie A.B.M., Elimination of Hand-Wrist Radiographs for Maturity Assessment in Children Needing Orthodontic Therapy, Skeletal Radiology 2008. 2007, 37: 195-200.

 

Alkhal H.A., Wong R.W.K. and Rabie A.B.M., Correlation between Chronological Age, Cervical Vertebral Maturation and Fishman’s Skeletal Maturity Indicators in Southern Chinese, Angle Orthodontist. 2008, 78, No.4: 591-596.

 

Cendekiawan T., Wong R.W.K. and Rabie A.B.M., Temporal Expression of SOX9 and Type II Collagen in Spheno-Occipital Synchondrosis of Mice after Mechanical Tension Stimuli. , Angle Orthodontist. 2007, 78 No. 1: 83-88.

 

Finn G., Rabie A.B.M. and Wong R.W.K., Inhibitory effect of Quercetin on Periodontal pathogens, The 19th Convocation of the Royal Australasian College of Dental Surgeons, Conjoint with The College of Dental Surgeons of Hong Kong. Hong Kong Convention & Exhibition Centre, Hong Kong, 30 May – 2 June, 2008.

 

Hagg E.U.O., Wong R.W.K., Samaranayake L.P., Kao R. and Yuen M., A Natural Edible Agent for Reduction of Oral Biofilm, IADR/GSK Innovation in Oral Care Awards. Awarded by IADR and GlaxoSmithKline Consumer Healthcare, 2 – 5 July, 2008 . 2008.

 

Hagg E.U.O., Wong R.W.K., Samaranayake L.P., Kao R. and Yuen M., A Natural Edible Agent for Reduction of Oral Biofilm, IADR/GSK Innovation in Oral Care Awards. External funding, US$ 75,000 unrestricted research grant. Awarded by IADR and GlaxoSmithKline Consumer Healthcare, 2 – 5 July, 2008. 2008.

 

Hagg E.U.O., Ng T.C.S. and Wong R.W.K., Anterior Bite: Interceptive Treatment, Dental Asia. 2008, September/October 2007: 39-45.

 

Hagg E.U.O., Wong R.W.K. and Tng T.T.H., Severe transposition, ectopic eruption, and orthodontic alignment: A long-term appraisal, World Journal of Orthodontics. 2007, 8, Issue 3: 232-240.

 

Lee C.K., McGrath C.P.J., Wong R.W.K. and Rabie A.B.M., Patient's perceptions regarding microimplant as anchorage in orthodontics, Angle Orthodontist. 2008, 78: 228-233.

 

Lee T.C.K., Rabie A.B.M., Wong R.W.K. and McGrath C.P.J., Patients’ Perceptions Regarding Microimplant as Anchorage in Orthodontics, Outstanding Poster Award. Second International Conference on Evidence-based Advanced Dentistry, Conjoint Congress 2007. Hong Kong, China, 16 – 19 November, 2007. 2007.

 

Lee T.C.K., Leung M.T.C., Wong R.W.K. and Rabie A.B.M., Versatility of skeletal anchoarage in orthodontics, World Journal of Orthodontics. 2008, 9: 221-232.

 

Lee W., Wong R.W.K., Ikegami T. and Hagg E.U.O., Maxillary Second Molar Extractions in Orthodontic Treatment, World Journal Orthodontics 2008. 2008, 9: 52-61.

 

Lei S.W.Y., Wong R.W.K. and Rabie A.B.M., Factors Regulating Endochondral Ossification in the Spheno-occipital Synchondrosis. , Angle Orthodontist . 2007, 78, No.2: 215-220.

 

Leung M.T.C., Lee T.C.K., Rabie A.B.M. and Wong R.W.K., Stability of connected mini-implants and miniplate for skeletal anchorage in orthodontics, European Journal of Orthodontics. 2008, 30: 483-489.

 

Leung M.T.C., Lee T.C.K., Rabie A.B.M. and Wong R.W.K., Use of Miniscrews and Miniplates in Orthodontics, Journal of Oral and Maxillofacial Surgery 2008. 2008, 66: 1461-1466.

 

Ling J.Y.K. and Wong R.W.K., Incisal Morphology of Southern Chinese, The Open Anthropology Journal 2008. 2008, 1: 19-25.

 

Ling J.Y.K. and Wong R.W.K., Tooth Dimensions of Southern Chinese in Hong Kong. An Image Analytic Study , Dental Asia. 2007, July/August: 19-29.

 

Ng C.S.T., Wong R.W.K. and Hagg E.U.O., Orthodontic treatment of anterior open bite. , International Journal of Paediatric Dentistry . 2008, Vol. 18: 78-83.

 

Purkayastha S.L., Rabie A.B.M. and Wong R.W.K., Treatment of skeletal Class II malocclusion in adults: Stepwise vs single-step advancement with the Herbst appliance, World Journal of Orthodontics. 2008, 9: 233-243.

 

Rabie A.B.M., Wong R.W.K. and Gu M., Treatment in borderline Class III malocclusion: orthodontic camouflage (extraction) versus orthognathic surgery, The Open Dentistry Journal. 2008, 2: 38-48.

 

Rukkulchon B.K. and Wong R.W.K., Effect of Tensile Force on Expression of PTHrP and Thickness of Hypertrophic Zone in Organ-cultured Mouse Spheno-occipital Synchondroses, Archives of Oral Biology 2008. 2008, 53: 690-699.

 

Seneviratne C.J., Wong R.W.K. and Samaranayake L.P., Potent anti-microbial activity of traditional Chinese medicine herbs against Candida species, Mycoses. 2008, 51(1): 30-34.

 

Shum L.M.Y. and Wong R.W.K., Autotransplantation of premolars with closed root apices: an orthodontic case report, Hong Kong Dental Journal . 2007, Vol. 4 No.2, December: 122-127.

 

Tang J.Y., Zeng Y.S., Chung P., Wong R.W.K. and Hagg E.U.O., Effects of Valeriana officinalis extract on rat depressive model., Journal of Chinese Clinical Medicine 2008,. 2008, 3, No. 7: 374-378.

 

Tsui V.W.K., Wong R.W.K. and Rabie A.B.M., The Inhibitory Effect of Naringin on The Growth of Periodontal Pathogens In Vitro. , Phytotherapy Research . 2008, 22: 401-406.

 

Wiechmann D., Wong R.W.K. and Hagg E.U.O., Incognito – the Novel CAD/CAM Lingual Orthodontic Appliance. , Dental Asia . 2008, January/ February 2008: 19-25.

 

Wong R.W.K., Chairman of Session,Oral Presentations: Parallel Session II , Inaugural Conjoint Dental Scientific Meeting, The University of Hong Kong and Wuhan University, 10 – 11 May, 2008. 2008.

 

Wong R.W.K., Chairman of Session. Oral Session II: Orthodontics., Second International Conference on Evidence-based Advanced Dentistry, Conjoint Congress 2007. Hong Kong, China, 16 – 19 November, 2007. . 2007.

 

Wong R.W.K. and Rabie A.B.M., Chapter IV - Herbal Drug Research on Bone Regeneration , In 'Chinese Herbal Drug Research'. Nova Science Publishers, Inc. New York. 2008. ISBN: 1-60021-928-4. 2008, 123-145.

 

Wong R.W.K., Chinese Medicinal Plants in Arthritis , In the Series 'Recent Progress in Medicinal Plants' . LCC, Studium Press, 2007, 20.

 

Wong R.W.K. and Rabie A.B.M., Chinese Medicinal Plants in Arthritis, Volume 20 of the Series - Recent Progress in Medicinal Plants' Phytopharmacology and Therapeutic Values II. . LLC, USA, Stdium Press, 2007, 20.

 

Wong R.W.K. and Rabie A.B.M., Chinese red yeast rice (Monascus purpureus-fermented rice) promotes bone formation, Chinese Medicine. 2008, 3: 4.

 

Wong R.W.K., Dental Visions Symposium: Traditional Chinese Medicine in Dentistry – post, present, future, Second International Conference on Evidence-based Advanced Dentistry, Conjoint Congress 2007. Hong Kong, China, 16 – 19 November, 2007. 2007.

 

Wong R.W.K., Different Method of Orthodontics, Ming Pao Daily 2007. 2007.

 

Wong R.W.K. and Rabie A.B.M., Effect of Danshen extract on Bone Formation, The 19th Convocation of the Royal Australasian College of Dental Surgeons, Conjoint with The College of Dental Surgeons of Hong Kong. Hong Kong Convention & Exhibition Centre, Hong Kong, 30 May – 2 June, 2008.

 

Wong R.W.K. and Rabie A.B.M., Effect of Quercetin on Preosteoblasts and Bone Defects, The Open Orthopaedics Journal. 2008, Vol. 2: 27-32.

 

Wong R.W.K. and Rabie A.B.M., Effect of Salvia miltiorrhixa extract on bone formation, Journal of Biomedical Materials Research 2008 . 2008, 85A: 506-512.

 

Wong R.W.K., Grapefruit flavonoid as bone inductive and antibacterial agent, BioX@ Science Park, Hong Kong Science Park, 28 April, 2008 . 2008.

 

Wong R.W.K. and Rabie A.B.M., Local Massage with Topical Analgesic, a Novel Treatment Modality for Temporomandibular Muscular Pain, a Case Study Report of 5 Consecutive Cases., Open Orthopaedics Journal . 2008, 2: 93-98.

 

Wong R.W.K. and Rabie A.B.M., Local message with topical analgesic, a novel treatment modality for temporomandibular muscular pain, a case study report of 5 consecutive cases, The Open Orthopaedics Journal. 2008, 2: 93-98.

 

Wong R.W.K., Methods of Orthodontics, Sing Tao Daily 2007. 2007.

 

Wong R.W.K., Motivation Theories in Dentistry, Oral Health and Science Seminars, The Prince Philip Dental Hospital, Faculty of Dentistry, University of Hong Kong, 23 January, 2008. 2008.

 

Wong R.W.K. and Young F.Y.F., Naringin and its aglycone, research and managements, Bioactive National Products . 2008.

 

Wong R.W.K. and Wu C.C.L., Orthodontic treatment using Round Multiloop Edgewise Arch-Wire (MEAWR): A case report. , Hellenic Orthodontic Review . 2007, Vol. 10 Issue 2: 93-102.

 

Wong R.W.K., Orthodontics in Cleft Lip and Palate Patients, Invitation of a talk– Hong Kong Association for Cleft Lip and Palate, 25 January, 2008. . 2008.

 

Wong R.W.K., Reverse Headgear - What is the ideal treatment time?, Oral Health and Science Seminars, The Prince Philip Dental Hospital, Faculty of Dentistry, University of Hong Kong, 3 October, 2007. 2007.

 

Wong R.W.K., Reviewer: Planta Medica (2008). 2008.

 

Wong R.W.K., The Open Orthopaedics Journal , Reviewer – an Editorial Board Member (2008). 2008.

 

Wong R.W.K., The Research Output Prize in 2008. 2008.

 

Wong R.W.K., Rabie A.B.M., Bendeus M. and Hagg E.U.O., The effects of Rhizoma Curculiginis and Rhizoma Drynariae extracts on bones , Chinese Medicine . 2007, 2: 1-13.

 

Wong R.W.K. and Rabie A.B.M., The use of HMG-CoA reductase inhibitors as bone induction materials. , In: Bloomington D.R., Nova Science Publishers, Inc, New York, New Research on Biomaterials.. 2007, 1-48.

 

Wong R.W.K., Traditional Chinese Medicine in Dentistry – past, present, future, Macau University of Science and Technology, Macau, 9 April, 2008. 2008.

 

Wu A.K.Y., McGrath C.P.J., Wong R.W.K. and Rabie A.B.M., A comparison of pain experienced by patients treated with labial & lingual orthodontic appliances, The 19th Convocation of the Royal Australasian College of Dental Surgeons, Conjoint with The College of Dental Surgeons of Hong Kong. Hong Kong Convention & Exhibition Centre, Hong Kong, 30 May – 2 June, 2008.

 

Wu C.C.L., Wong R.W.K. and Hagg E.U.O., A review of hypodontia: the possible etiologies and orthodontic, surgical and restorative treatment options – conventional and futuristic., Hong Kong Dental Journal . 2007, Vol. 4 No.2, December: 113-121.

 

Young F.Y.F. and Wong R.W.K., Dental Asia 2008, The use of Motivation Theories in Dentistry. 2008, May/ June 2008: 24-28.

 

Young F.Y.F. and Wong R.W.K., The Impact of Human Resource Management on Business Success of Dental Practices, Dental Asia . 2008, March/ April 2008: 30-33.

 

Researcher : Wu JYC

List of Research Outputs

 

Zhou L., Mok C.W., Hagg E.U.O., McGrath C.P.J., Bendeus S.A.M. and Wu J.Y.C., Anteroposterior Dental Arch and Jaw-Base Relationships in a Population Sample, Angle Orthodontist. 2008, 78: 1023-1029.

 

Researcher : Yang Y

List of Research Outputs

 

Chen D.P., Yang Y. and Zhu S.J., Functional appliance, In: Fu MK, Textbook of orthodontics. Beijing, People’s Medical Publishing House, 2007, 268-274.

 

Cui L., Yang Y., Li X.T., Zhang D. and Fu M.K., Effect of Fluid Shear Stress on the expression of bone markers in MLO-Y4 Osteocyte-Like Cells, Chinese Journal of Orthodontics. 2007, 14: 127-130.

 

Cui L., Yang Y., Li X.T., Zhang D. and Fu M.K., Effects of fluid shear stress on expressions of RANKL, OPG and OCN in MLO-Y4 osteocyte-like cells, 8th Orthodontic Conference of China. 2007.

 

Feng J.S. and Yang Y., Method of making and using anterior root torquing auxillary arch, Chinese Journal of Orthodontics. 2007, 14: 42.

 

Hu W., Lu H.P. and Yang Y., Anchorage and anchorage control in orthodontics, In: Fu MK, Textbook of orthodontics. Beijing, People’s Medical Publishing House, 2007, 314-327.

 

Li X.T., Cui L., Yang Y., Zhang D. and Fu M.K., Age effects on osteoclasts in retention after orthodontic tooth movement, 6th Asian-Pacific Orthodontic Conference. 2008.

 

Li X.T., Cui L., Yang Y., Zhang D. and Fu M.K., Osteoclastic activity and age effect during orthodontic retention in rats, 8th Orthodontic Conference of China. 2007.

 

Meng K., Li X.T., Yang Y., Cui L., Fu M.K. and Zhang D., A comparative study of multiloop edgewise arch wire and nickel-titanium wire in vivo and in vitro, The International Journal of the MEAW Technic and Research Foundation. 2007, 14: 3-12.

 

Yang Y., Assistant editor-in-chief, In: Editor-in-chief: Fu MK, Textbook of orthodontics. 2007.

 

Yang Y., Associate editor-in-chief, In: Editor-in-chief: Zhang D, Strategy for complex orthodontic cases. 2007.

 

Yang Y., Case selection from the membership in orthodontics for the royal college of surgeons of Edinburgh, Editor, 2007.

 

Yang Y., Cephalometrics, Orthodontic Training Course, the Continuing Education Program of Chinese Stomatological Association, Shanghai. 2008.

 

Yang Y., Headgear-Activator followed by fixed appliance for class II division 1, In: Zeng XL, Case selection from the membership in orthodontics for the royal college of surgeons of Edinburgh. Beijing, Peking University Medical Press, 2007, 3-17.

 

Yang Y. and Chen S., Impression and study models in orthodontic clinic, In: Fu MK, Textbook of orthodontics. Beijing, People’s Medical Publishing House, 2007, 105-111.

 

Yang Y., Non-extraction treatment of Class III malocclusion in early permanent dentition, In: Zeng XL, Case selection from the membership in orthodontics for the royal college of surgeons of Edinburgh. Beijing, Peking University Medical Press, 2007, 129-136.

 

Yang Y., Orthodontics and temporomandibular disorders, In: Zhang D, Strategy for complex orthodontic cases. Beijing, People’s Medical Publishing House, 2007, 157-190.

 

Yang Y. and Zhu S.J., Orthopedic appliance, In: Fu MK, Textbook of orthodontics. People’s Medical Publishing House, 2007, 249-264.

 

Yang Y., Ren Y.X. and Zeng X.L., Retrospective study on anterior open bite or incomplete overbite secondary to condylar resorption, Inaugural Conjoint Dental Scientific Meeting of the University of Hong Kong and Wuhan University. 2008.

 

Yang Y., Typodont, Orthodontic Training Course, the Continuing Education Program of Chinese Stomatological Association, Shanghai. 2008.

 

Researcher : Yau JYY

List of Research Outputs

 

Samaranayake Y.H., Samaranayake L.P., Cheung B.P.K., Parahitiyawa N.B., Yau J.Y.Y. and Yeung S.K.W., Synergistic Inhibition of Candida biofilms by Lysozyme and Common Antifungals , Inaugural Conjoint Dental Scientific Meeting. The University of Hong Kong and Wuhan University 2008.

 

Researcher : Yeung MK

List of Research Outputs

 

Chu C.H., Cheng H.F., Chiu H.C., Chiu L.P.Y., Choi T.Y., Lai I.A., Lee Y.M., Lo V.Y.M., Wu W.S. and Yeung M.K., Oral health status and oral features of Chinese people with Systemic Sclerosis (Scleroderma) in Hong Kong, Community Health Project Report Series. Faculty of Dentistry, The University of Hong Kong, 2008, 154: 1-53.

 

Researcher : Yeung RWK

Project Title:

Prospective study on arthrocentesis

Investigator(s):

Yeung RWK, Cheung LK

Department:

Dental Faculty

Source(s) of Funding:

Low Budget High Impact Programme

Start Date:

11/2001

 

Abstract:

To determine the short and long term benefit of TMJ arthrocentesis in closed locking joints; to compare the sodium hyaluronate and steriod and normal saline in TMJ arthrocentesis; to determine the intraarticular joint pressure during closed lock and the pressure changes following treatment; to determine the biochemical markers in the closed lock joints - e.g. cytokines.

 

List of Research Outputs

 

Lee L.T.K., Yeung R.W.K., Wong M.C.M. and McMillan A.S., Diagnostic sub-types, psychological distress and psychosocial dysfunction in southern Chinese people with temporomandibular disorders, Journal of Oral Rehabilitation. 2008, 35(3): 184-90.

 

Researcher : Yeung RWK

List of Research Outputs

 

Lee L.T.K., Yeung R.W.K., Wong M.C.M. and McMillan A.S., Diagnostic sub-types, psychological distress and psychosocial dysfunction in southern Chinese people with temporomandibular disorders, Journal of Oral Rehabilitation. 2008, 35(3): 184-90.

 

Researcher : Yeung SKW

List of Research Outputs

 

Samaranayake Y.H., Samaranayake L.P., Cheung B.P.K., Parahitiyawa N.B., Yau J.Y.Y. and Yeung S.K.W., Synergistic Inhibition of Candida biofilms by Lysozyme and Common Antifungals , Inaugural Conjoint Dental Scientific Meeting. The University of Hong Kong and Wuhan University 2008.

 

Researcher : Yip HK

Project Title:

The effects of bacteria derived endotoxin on osteogenic and neurogenic differentiation of bone marrow derived stem cells

Investigator(s):

Yip HK, Chan GCF

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

11/2004

 

Abstract:

To evaluate the effect of endotoxin on the osteogenic differentiation of human bone marrow derived mesenchymal stem cells (MSCs).

 

Project Title:

Influence of Different Surface Treatment of Titanium on the Osteogenic Proliferation of Human Mesenchyamal Stem Cells.

Investigator(s):

Yip HK

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

09/2005

 

Abstract:

To evaluate the effect of different surface of titanium on the osteogenic differentiation of human bone marrow derived mesenchymal stem cells (MSCs).

 

Project Title:

Local delivery of hMSCs and re-constituted collagen for rapid bone regeneration.

Investigator(s):

Yip HK, Chan GCF, Chan BP, Chan D

Department:

Dental Faculty

Source(s) of Funding:

Small Project Funding

Start Date:

09/2006

 

Abstract:

Implant dentistry has been successfully practised for over two decades and its efficacy is proven by long-term clinical trials (Esposito et al., 2005). But problems remain such as the loss of alveolar bone and supportive structures in edentulous areas or loosening of the implant due to suboptimal integration of the implant with the supporting structures. The use of multipotential stem cells to improve the formation of supportive structures is therefore a very appealing approach. Stem cell based composite with collagen scaffolds is becoming a critical part in the bone generation and osseointegration process after the implant surgery.

 

List of Research Outputs

 

Chan Y.M., Smales R.J., Yip H.K. and Sung W.K., Transluency of biaxial flexural strength of four ceramic core materials, Dental Materials. 2008, 24: 1506-1511.

 

Chen L.-.J., Chen Y.M., Guang H.-.B., Smales R.J. and Yip H.K., In vitro study of dentine tubule occlusion after fluoride iontophoresis. , J Dent. UK, 2008, 36: 697-702.

 

Mei L., Fang H.H.P., Zhang T., Jin L.J. and Yip H.K., The use of chlorhexidine in reducing the cariogenicity of oral microbial biofilm with caries free and high risk of caries. , the Inaugural Conjoint Dental Scientific Meeting The University of Hong Kong and Wuhan University.. China, 2008, 38.

 

Meng Q.-.F., Chen Y.M., Guang H.B., Yip H.K. and Smales R.J., The effect of ferrule length on fracture resistance of endodontically treated teeth restored with different post-and-core materials. , Oper Dent . USA, 2007, 32: 595-601.

 

Mo I.F.Y., Yip H.K., Chan W.K., Law H.K.W., Lau Y.L. and Chan C.C.F., Prolonged exposure to bacterial toxin will donaregenerate expression of toll-like receptors in mesenchymal stromal cell-derived osteroprogenitors, BMC Cell Biology. 2008, 9: 52.

 

Smales R.J., Poon E.C.M., Yip H.K. and Ngo H.C., Packable and conventional resin-based composites restoring posterior teeth: SEM evaluation of margins after 3.5 years., Journal of The Asia-Pacific Academy of Dentistry . Hong Kong, The Asia-Pacific Academy of Dentistry, 2007, 1: 1-6.

 

Sun Y.-.S., Chen Y.-.M., Yip H.K. and Smales R.J., Fracture resistance and microtensile bond strength of maxillary premolars restored with two resin composite inlay systems., Am J Dent . 2008, 21: 97-100.

 

Wang J.-.J., Chen Y.M., Yip H.K., Smales R.J., Meng Q.-.F. and Chen L.-.J., Effect of two fiber post types and two luting cement systems on regional post retention using the push-out test., Dent Mater. 2008, 24: 372-377.

 

Wong C.H., Yip H.K. and Chan G.C.F., Effect of Various Culture Surfaces on Human Mesenchymal Stem Cells, 12th Research Postgraduate Symposium, Hong Kong, 14 December 2007. 2007-12-14.

 

Yip H.K., Mo F.Y., Law H.K.W., Lau Y.L. and Chan G.C.F., Adaptive response of hMSC-derived osteoprogenitors to LPS enriched environment, AADR 37th Annual Meeting and Exhibition, Dallas, Texas, USA, J Dent Res 2008, 5th April, 2008. 1191.

 

Yip H.K., Cariogenic micro-organisms in high caries risk patients and coronary heart diseases. , In: Johnson and Johnson Symposium, dent25 Silver Jubilee Celebrations of the Faculty of Dentistry, The University of Hong Kong, Hong Kong , Cariogenic micro-organisms in high caries risk patients and coronary heart diseases. . Hong Kong, 2007.

 

Yip H.K., Regional Associate Editor, The Asia-Pacific Academy of Dentistry. Hong Kong, 2007.

 

Researcher : Yiu CKY

List of Research Outputs

 

Anthonappa R.P., Yiu C.K.Y. and King N.M., A novel combination of dens evaginatus and dens invaginatus in a single tooth - review of the literature and a case report., J Clin Paediatr Dent. 2008, 32(3): 239-242.

 

Bridges S.M., McGrath C.P.J. and Yiu C.K.Y., When official policies meet site-based realities: Diversity and clinical dental education in Hong Kong, Eighth International Conference on Diversity in Organisations, Communities and Nations. 2008.

 

Bridges S.M., McGrath C.P.J. and Yiu C.K.Y., Working the ‘place’ of languages in clinical dental education, 9th International Conference of the Association for Language Awareness. 2008.

 

Chung C.W.M., Yiu C.K.Y., King N.M. and Hiraishi N., Effect of saliva contamination on bond strength of luting cements to dentine., Inaugural University of Hong Kong - Wuhan University Conjoint Scientific Meeting, Donggguan, China, May 10. 2008, Abstract P-21.

 

Dhanpal P.K., Yiu C.K.Y. and King N.M., A review of dentin adhesives in pediatric dentistry, Hong Kong Dental Journal. 2007, 4(2): 80-89.

 

Dhanpal P.K., Yiu C.K.Y., King N.M., Tay F.R.C.M. and Hiraishi N., Effect of temperature on water sorption and solubility of dental adhesive resins, Second International Conference on Evidence-based Advanced Dentistry, Conjoint Congress 16-19 November, Hong Kong. 2007. P.68 Abstract P-26.

 

Dyson J.E., Yiu C.K.Y., Samaranayake L.P., Bridges S.M., Lane T., Chan J.P.S., Cheng S.W. and Leung R.T.C., Problem-based learning in dentistry. Hong Kong, Faculty of Dentistry, The University of Hong Kong, 2008.

 

Ekambaram M., Yiu C.K.Y. and King N.M., An unusual case of double teeth with facial and lingual talon cusps., Oral Surgery, Oral Medicine, Oral Radiology and Endodontology. 2008, 105: e63-67.

 

Hiraishi N., Yiu C.K.Y., King N.M., Tay F.R.C.M. and Pashley D.H., Chlorhexidine release and water sorption characterisitcs of chlorhexidine-incorporated hydrophobic/hydrophilic resins., Dent Materials. 2008, 24: 1391-9.

 

Hiraishi N., Yiu C.K.Y., King N.M., Tay F.R.C.M. and Pashley D.H., Chlorhexidine release and water sorption characteristics of chlorhexidine-incorporated dental adhesive resins, Second International Conference on Evidence-based Advanced Dentistry, Conjoint Congress 16-19 November, Hong Kong. 2007. P.71 P-30.

 

Hiraishi N., Yiu C.K.Y. and King N.M., Effect of acid etching time on bond strength of an etch-and-rinse adhesive to primary tooth dentine affected by amelogenesis imperfecta. , International Journal of Paediatric Dentistry. 2008, 18(3): 224-230.

 

Peerzada F., Yiu C.K.Y., King N.M. and Hiraishi N., Effect of surface preparation on bond strength of luting cement to dentine, Inaugural University of Hong Kong - Wuhan University Conjoint Scientific Meeting, Donggguan, China. May 10, 2008. P-22.

 

Yiu C.K.Y., Dentine bonding-the state of the art, Second International Conference on Evidence-based Advanced Dentistry. 2007.

 

Yiu C.K.Y., Hiraishi N., King N.M. and Tay F.R., Effect of dentinal surface preparation on bond strength of self-etching adhesives, Journal of adhesive dentistry. 2008, 10: 173-182.

 

Yiu C.K.Y., Hiraishi N., King N.M. and Tay F.R.C.M., Effect of pulpal pressure on bond strength of luting cements to dentin, Second International Conference on Evidence-based Advanced Dentistry, Conjoint Congress 16-19 November, Hong Kong. 2007. P.38 O-17.

 

Yiu C.K.Y., Outstanding Research Postgraduate Student Award, Graduate School, the University of Hong Kong. 2007.

 

Yiu C.K.Y., Research Output Prize, Faculty of Dentistry, The University of Hong Kong. 2007.

 

Researcher : You DSH

List of Research Outputs

 

Hon A.K., Choi B.S.K., Siu E.K.S., You D.S.H. and Wong M.C.M., Attitudes towards advertising in dentistry in Hong Kong, Journal of Dental Research. 2007, 86 (Spec Iss B): IO-24.

 

You D.S.H., Chu C.H. and Lo E.C.M., Precision of clinical diagnosis of fissure caries by different methods, Journal of Dental Research. 2007, 86 (Spec Iss B): IP-027.

 

Researcher : Zaw MT

List of Research Outputs

 

Zaw M.T., Samaranayake Y.H. and Samaranayake L.P., Characteristics of dual species candida biofilms on denture acrylic surfaces, Archives of Oral Biology. 2007, 52: 1200-1208.

 

Zaw M.T., Samaranayake Y.H. and Samaranayake L.P., Dietary sugars, serum and the biocide chlorhexidine digluconate modify the population and structural dynamics of mixed Candida albicans and Escherichia coli biofilms, APMIS. 2007, 115: 1241-1251.

 

Researcher : Zee KY

List of Research Outputs

 

Chai L., Leung W.K., Zee K.Y. and Song Y., Association between FCGR3A polymorphisms and periodontitis in Hong Kong Chinese, Journal of Dental Research. 2007, 86 (Spec Iss B): IP-131.

 

Chan P.S., Ho J.C.S., Zee K.Y., Corbet E.F. and Leung W.K., The adjunctive use of Chinese medicine in non-surgical periodontal therapy, Journal of Dental Research. 2007, 86 (Spec Iss B): IP-141.

 

Chong D.L.H., Zee K.Y. and Corbet E.F., Bone changes around osseointegrated dental implants in smokers and non-smokers, Journal of Dental Research. 2007, 86 (Spec Iss B): IP-118.

 

Fung G.W.K., Zee K.Y. and Corbet E.F., Peri-implant bone level changes in patients with stable periodontal conditions, Journal of Dental Research. 2007, 86 (Spec Iss B): IP-071.

 

Fung G.W.K., Zee K.Y. and Corbet E.F., Peri-implant bone levels in patients treated for periodontitis, Inaugural University of Hong Kong - Wuhan University Conjoint Scientific Meeting, Donggguan, China, May 10. 2008.

 

Lai S.M.L., Zee K.Y. and Corbet E.F., Implant reconstructions in periodontally susceptible patients, Hong Kong Dental Journal. 2008, 5: 11-18.

 

Researcher : Zhang H

List of Research Outputs

 

Zhang H. and Darvell B.W., Effect of amine additives on the morphology of hydroxyapatite, Key Engineering Materials. Switzerland, Trans Tech Publications, 2008, 361-363: 115-118.

 

Researcher : Zhang M

List of Research Outputs

 

Hagg E.U.O., McGrath C.P.J. and Zhang M., Quality of life and orthodontic treatment need related to occlusal indices, The Hong Kong Medical Diary. 2007, 12: 8-11.

 

Zhang M., McGrath C.P.J. and Hagg E.U.O., Changes in oral health-related quality of life during fixed orthodontic appliance therapy, American Journal of Orthodontics and Dentofacial Orthopedics. 2008, 133: 25-29.

 

Researcher : Zheng L

List of Research Outputs

 

Ke J., Zheng L. and Cheung L.K., Characterization of rabbit bone marrow stromal cells after cryopreservation, Inaugural Conjoint Dental Scientific Meeting, The University of Hong Kong and Wuhan University. 10-11 May, 2008, China. 2008, p. 36.

 

Ma L., Zheng L. and Cheung L.K., Changes in blood supply and bone regeneration induced by nicotine during distraction osteogenesis, Bone. 2008, 42, S1: p. S60.

 

Ma L., Zheng L. and Cheung L.K., Influence of Nicotine on the expression of angiogenic factors in distraction osteogenesis, 1st International Bone and Dental Technology Symposium, November 2007, Bangkok, Thailand. 2007, p. 72.

 

Ma L., Zheng L. and Cheung L.K., The impact of Nicotine on blood perfusion and bone regeneration in distraction osteogenesis, Inaugural Conjoint Dental Scientific Meeting, The University of Hong Kong and Wuhan University. 10-11 May, 2008, China. 2008, p. 17.

 

Ma L., Zheng L. and Cheung L.K., The impact of nicotine on bone regeneration in distraction osteogenesis, Second International Conference on Evidence-based Advanced Dentistry, Conjoint Congress 16 - 19 November 2007, Hong Kong. 2007, p. 35 (# 013).

 

Wu Z.X., Zheng L., Dong Y.J., Li Z.B., Zhang W.F. and Zhao Y.F., Modified Approach for Lingual Thyroid Transposition: Report of Two Cases., Thyroid. 2008, 18: 465-8.

 

Zheng L., Biological and Molecular fundation of distraction osteogenesis, Synthes Distraction Course (Hong Kong 2008). The University of Hong Kong, 2008.

 

Zheng L., Ma L. and Cheung L.K., Changes in blood perfusion and bone healing induced by nicotine during distraction osteogenesis. , Bone. 2008, 43: p. 355-361.

 

Zheng L. and Cheung L.K., Effect of recombinant human bone morphogenetic protein-2 on mandibular distraction osteogenesis, Hong Kong Dental Journal . 2007, 4 (No. 2): p. 94-100.

 

Zheng L., Cheung L.K., Ma L. and Wong M.C.M., High-rhythm automatic driver for bone traction: an experimental study in rabbits. , Int J Oral Maxillofac Surg . 2008, 37: p 736-740.

 

Zheng L., Ma L. and Cheung L.K., Influence of continuous traction on the gene expression of BMP-2 and TGF-β in distraction osteogenesis, 1st International Bone and Dental Technology Symposium, November 2007, Bangkok, Thailand. 2007, p. 63.

 

Zheng L., Ma L. and Cheung L.K., Influence of distraction frequency on angiogenesis in rabbit mandibular lengthening, Inaugural Conjoint Dental Scientific Meeting, The University of Hong Kong and Wuhan University. 10-11 May, 2008, China. 2008, p. 15.

 

Zheng L., Ma L. and Cheung L.K., Influence of frequency of mechanical traction on gene expression and angiogenesis in rabbit mandibular lengthening, Bone. 2008, 42, S1: p. S66 - S67.

 

Zheng L., Outstanding Oral Presentation Award at the Second International Conference on Evidence-based Advanced Dentistry, The University of Hong Kong. 2007.

 

Zheng L., Ma L. and Cheung L.K., Shall we rewrite the distraction protocol for continuous distraction osteogenesis?, Second International Conference on Evidence-based Advanced Dentistry, Conjoint Congress 16-19 November 2007, Hong Kong. 2007, p. 35 (# 012).

 

Researcher : Zhu H

List of Research Outputs

 

Zhu H., McGrath C.P.J., McMillan A.S. and Li L.S.W., Can caregivers be used in assessing oral health-related quality of life among patients hospitalized for acute medical conditions?, Community Dentistry and Oral Epidemiology. 2008, 36: 27-33.

 

Zhu H., McMillan A.S., McGrath C.P.J., Li L.S.W. and Samaranayake L.P., Oral carriage of yeasts and coliforms in stroke sufferers: a prospective longitudinal study, Oral Diseases. 2008, 14(1): 60-66.

 

Researcher : Zwahlen RA

List of Research Outputs

 

Bütow K...W..., Jacobs F...J... and Zwahlen R.A., Variations of the isolated cleft of the hard palate, SADJ. 2008, 63, No. 3: p. 164 - 168.

 

Bütow K.W., van Wyk P.J. and Zwahlen R.A., Differences in the clinical appearances of white versus black patients with facial cleft deformities: a retrospective study of a South African clinic, South African Dental Journal. 2007, 62 (7): p. 298, 300-4.

 

Dannemann C..., Grätz K...W... and Zwahlen R.A., Bisphosphonate induced osteonecrosis of the jaws - A paper for prevention and diagnostic for daily dental work (German), Schweiz Monatsschr Zahnmed. 2008, 118: p. 113 - 118.

 

Drabe N..., Zwahlen D..., Büchi S..., Moergeli H..., Zwahlen R.A. and Jenewein J..., Psychiatric morbidity and quality of life in wives of men with long-term head and neck cancer, Psycho-Oncology. 2008, 17: p, 199-204.

 

Jayaratne Y.S.N., Lo J., Zwahlen R.A. and Cheung L.K., Virtual craniofacial model fabrication for surgical planning, Inaugural Conjoint Dental Scientific Meeting, The University of Hong Kong and Wuhan University. 10-11 May, 2008, China. 2008, p. 44.

 

Jenewein J..., Zwahlen R.A., Zwahlen D..., Drabe N..., Moergeli H... and Büchi S..., Quality of life and dyadic adjustment in oral cancer patients and their female partners, European Journal of Cancer Care. 2008, 17: p. 127 - 135.

 

Luebbers H...T..., Messmer P..., Obwegeser J...A..., Zwahlen R.A., Kikinis R..., Graetz K...W... and Matthews F..., Comparison of different registration methods for surgical navigation in cranio-maxillofacial surgery, Journal of Cranio-Maxillofacial Surgery. 2008, 36: p. 109 - 116.

 

Zwahlen R.A., Merit award received in September 2007 regarding clinical and scientific contribution to the formation of the dental proceation at the University of Zurich, Switzerland. September 2007, 2007.

 

Zwahlen R.A., Dannemann C., Grätz K.W., Studer G., Zwahlen D., Moergeli H., Drabe N., Büchi S. and Jenewein J., Quality of life and psychiatric morbidity in patients successfully treated for oral cavity squamous cell cancer and their wives, J Oral Maxillofac Surg. 2008, 66: p. 1125 - 1132.



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