Dept of Pharmacology

DEPT OF PHARMACOLOGY

Researcher : Chan CKY

List of Research Outputs

Chan C.K.Y., Man R.Y.K. and Vanhoutte P.M.G.R., Contractile response to hypoxia in the porcine coronary artery, 13th Research Postgraduate Symposium, December 10-11, 2008.

Chan C.K.Y., Mak J.C.W., Man R.Y.K. and Vanhoutte P.M.G.R., Contractile response to hypoxia in the porcine coronary artery, Twelfth Annual Scientific Meeting of Institute of Cardiovascular Science and Medince, December 13-14, 2008, Hong Kong. 2008.

Chan C.K.Y., Vanhoutte P.M.G.R., Man R.Y.K. and Mak J.C.W., Nitric oxide synthase and soluble guanylyl cyclase activation are required for hypoxic endothelium-dependent contractions of the porcine coronary artery, 10th International Symposium on Mechanisms of Vasodilatation, Matsushima, Miyagi, Japan, June 1-3, 2009.

Chan C.K.Y., Mak J.C.W., Man R.Y.K. and Vanhoutte P.M.G.R., Nitric oxide synthase and soluble guanylyl cyclase activation are required for hypoxic endothelium-dependent contractions of the porcine coronary artery, Twelfth Scientific Meeting of Hong Kong Pharmacology Society, June 12-15, 2009, Hong Kong. 2009.

Chan C.K.Y., Mak J.C.W., Man R.Y.K. and Vanhoutte P.M.G.R., Rho kinase inhibitors prevent endothelium-dependent contractions in the rat aorta, Fourth International Symposium on Healthy Aging of Research Centre of Heart, Brain, Hormone & Healthy Aging, March 7-8, 2009, Hong Kong. 2009.

Chan C.K.Y., Vanhoutte P.M.G.R., Man R.Y.K. and Mak J.C.W., Rho kniase inhibitors prevent endothelium-dependent contractions in the rats aorta, 10th International Symposium on Mechanisms of Vasodilatation, Matsushima, Miyagi, Japan, June 1-3, 2009.

Researcher : Chan KYC

List of Research Outputs

Chan K.Y.C., Mak J.C.W., Man R.Y.K. and Vanhoutte P.M.G.R., Rho kinase inhibitors prevent endothelium-dependent contractions in the rat aorta, J Pharmacol Exp Ther. 2009, 329: 820-826.

Researcher : Chan MLY

List of Research Outputs

Keung W.Y.W., Chan M.L.Y., Vanhoutte P.M.G.R., Leung S.W.S. and Man R.Y.K., The effect of 17b-estradiol on adenylyl cyclase and protein kinase G in the regulation of vascular tone, 10th International Symposium on Mechanisms of Vasodilatation 2009 . 2009.

Man R.Y.K., Keung W.W.Y., Chan M.L.Y. and Vanhoutte P.M.G.R., The effect of the female hormone, 17b-Estradiol, on adenylyl cyclase and protein kinase G in the regulation of vascular function, 10th International Symposium on Mechanisms of Vasodilatation, Matsushima, Miyagi, Japan, June 1-3, 2009.

Ng J.K.F., Chan M.L.Y., Man R.Y.K. and Vanhoutte P.M.G.R., Dexmedetomidine relaxes isolated porcine coronary arteries by activating endothelial  2A, 2B and 2C adrenoceptors, Mechanism of Vasodilatation MOVD 2009.

Ng J.K.F., Chan M.L.Y., Man R.Y.K. and Vanhoutte P.M.G.R., Dexmedetomidine relaxes isolated porcine coronary arteries by activating enothelial a 2A, 2B and 2C adrenoceptors, Mechanism of Vasodilatation MOVD 2009, Matsushima. 2009.

Researcher : Chow HM

List of Research Outputs

Lam J.B.B., Chow H.M., Xu A., Lam K.S.L., Liu J., Moon R.T., Shepherd P.R., Cooper G.J. and Wang Y., Adiponectin haploinsufficiency promotes mammary tumor development in MMTV-PyVT mice by modulation of phosphatase and tensin homolog activities., PLoS ONE. 2009, 4: e4968.

Liu J., Lam J.B.B., Chow H.M., Xu A., Lam K.S.L., Randall T. and Wang Y., Adiponectin stimulates Wnt inhibitory factor-1 expression through epigenetic regulations involving the transcription factor specificity protein 1, Carcinogenesis . 2008, 31: 1889-91.

Zhou M., Xu A., Tam P.K.H., Lam K.S.L., Chan L., Hoo R.L.C., Liu J., Chow H.M. and Wang Y., Mitochondrial dysfunction contributes to the increased vulnerabilities of adiponectin knockout mice to liver injury., Hepatology. 2008, 48 (4): 1087-96.

Zhou M., Xu A., Tam P.K.H., Lam K.S.L., Chan L., Liu J., Chow H.M. and Wang Y., Mitochondrial dysfunction contributes to the increased vulnerabilities of adiponectin knockout mice to liver injury, Fourth International Symposium on Healthy Aging: "Emerging Therapies for an Aging Population". 2009.

Researcher : Chow HM

List of Research Outputs

Researcher : Choy PC

List of Research Outputs

Ng W.W.H., Keung W.W.Y., Xu Y., Ng J.K.F., Leung G.P.H., Vanhoutte P.M.G.R., Choy P.C. and Man R.Y.K., Genistein otentiates protein kinase A activity in porcine coronary artery, Mol Cell Biochem. 2008, 311: 37-44.

Researcher : Ho YW

List of Research Outputs

Ho Y.W., Leung G.P.H., Man R.Y.K., Vanhoutte P.M.G.R. and Ng J.K.F., Distributions of alpha 2 adrenoceptor subtypes in porcine coronary vasculature. San Diego, 5-9 Apr , Experimental Biology . 2008.

Ho Y.W., Leung G.P.H., Man R.Y.K., Vanhoutte P.M.G.R. and Ng J.K.F., Distributions of alpha 2 adrenoceptor subtypes in porcine coronary vasculature, FASEB Journal. 2008, 22: 914.10.

Ho Y.W., Li W.S.R., Vanhoutte P.M.G.R., Man R.Y.K., Leung S.W.S. and Leung G.P.H., Possible role of organic cation transport-3 in serotonin uptake in human brain vascular smooth muscle cells, 10th International Symposium on Mechanisms of Vasodilatation 2009.

Ho Y.W., Li W.S.R., Vanhoutte P.M.G.R., Man R.Y.K., Leung S.W.S. and Leung G.P.H., Possible role of organic cation transpporter-3 in serotonin uptake in human brain vascular smooth muscle cells, Journal of vascular research . 2009, 46 supp 1: 202.

Leung G.P.H., Ho Y.W., Li W.S.R., Seto S.W. and Kwan Y.W., Diabetes- and hypertension-induced upregulation of concentrative nucleoside transporter-2 in endothelial cells, Journal of Vascular Research. 2009, 46 (Supp 1): 178.

Leung S.W.S., Ho Y.W., Man G.S.K., Leung G.P.H. and Man R.Y.K., Role of extracellular signal-related kinases in the pathophysiology of vascular dysfunction in aging and hypertension, 10th International Symposium on Mechanisms of Vasodilatation 2009 . 2009.

Leung S.W.S., Ho Y.W., Man G.S.K., Leung G.P.H. and Man R.Y.K., Role of extracellular signal-related kinases in the pathophysiology of vascular dysfunction in aging and hypertension, Journal of Vascular Reseach. 2009, 46 (supp 1): 110.

Ng J.K.F., Leung G.P.H., Ho Y.W., Man R.Y.K. and Vanhoutte P.M.G.R., Dexmedetomidine relaxes isolated porcine coronary artery via endothelial 2A receptors, Annual Meeting of the American Society of Anaesthesioogists, Orlando, 18-22 Oct. 2008.

Researcher : Keung WWY

List of Research Outputs

Man R.Y.K., Keung W.W.Y., Chan M.L.Y. and Vanhoutte P.M.G.R., The effect of the female hormone, 17b-Estradiol, on adenylyl cyclase and protein kinase G in the regulation of vascular function, 10th International Symposium on Mechanisms of Vasodilatation, Matsushima, Miyagi, Japan, June 1-3, 2009.

Ng W.W.H., Keung W.W.Y., Xu Y., Ng J.K.F., Leung G.P.H., Vanhoutte P.M.G.R., Choy P.C. and Man R.Y.K., Genistein otentiates protein kinase A activity in porcine coronary artery, Mol Cell Biochem. 2008, 311: 37-44.

Researcher : Keung WYW

List of Research Outputs

Keung W.Y.W., Chan M.L.Y., Vanhoutte P.M.G.R., Leung S.W.S. and Man R.Y.K., The effect of 17b-estradiol on adenylyl cyclase and protein kinase G in the regulation of vascular tone, 10th International Symposium on Mechanisms of Vasodilatation 2009 . 2009.

Researcher : Kong BWC

List of Research Outputs

Kong B.W.C., Man R.Y.K., Vanhoutte P.M.G.R. and Leung S.W.S., Hypertension and EDHF-mediated responses in mesenteric arteries of the rats, 10th International Symposium on Mechanisms of Vasodilatation, Matsushima, Miyagi, Japan, June 1-3, 2009.

Researcher : Kong WCB

List of Research Outputs

Kong W.C.B., Man R.Y.K., Vanhoutte P.M.G.R. and Leung S.W.S., Aging and hypertension attenuate relaxations due to endothelium-derived hyperpolarizing factor in the rat superior mesenteric artery , 10th International Symposium on Mechanisms of Vasodilatation 2009 . 2009.

Kong W.C.B., Leung S.W.S., Man R.Y.K. and Vanhoutte P.M.G.R., The effect of aging and hypertension on endothelial-derived hyperpolarizing factor (EDHF)-mediated responses in spontaneously hypertensive rats, Journal of the Hong Kong College of Cardiology, 2008/ The 12th Annual Scientific Meeting, Institute of Cardiovascular Science and Medicine, The University of Hong Kong . 2008, 16: 63.

Researcher : Koo MWL

List of Research Outputs

Koo M.W.L., Faculty Teaching Medal 2008, 2008.

Li Z., Koo M.W.L., Wang Y. and Vanhoutte P.M.G.R., Epigallocatechin gallate causes endothelium dependent contractions in the rat aorta, 10th International Symposium on Mechanisms of Vasodilatation, Matsushima, Miyagi, Japan, June 1-3, 2009.

Li Z., Koo M.W.L., Wang Y. and Vanhoutte P.M.G.R., Epigllocatechin gallate induces contractions of the rats aorta due to production of reactive oxygen species, activation of cyclooxygenase and stimulation of thromboxane-prostanoid receptor, Twelfth Scientific Meeting of Hong Kong Pharmacology Society, June 12-15, 2009 Hong Kong. 2009.

Researcher : Law KM

List of Research Outputs

Law K.M., Liu L., Xu A., Lam K.S.L., Vanhoutte P.M.G.R., Che C.M., Leung T.Y. and Wang Y., Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins., Proteomics. 2009, 9: 2444-56.

Law K.M., Xu A., Lam K.S.L., Liu T.C., Berger T., Mak T...W..., Zhang M...X...M... and Wang Y., Mice lacking lipicalin-2 show increased insulin sensitivity and are resistant to high fat diet- and genetic obesity-induced insulin resistance and diabetes, 13th Research Postgraduate Symposium, December 10-11, 2008.

Law K.M., Xu A., Lam K.S.L., Berger T.H.O.R.S.T.E.N., Mak T.A.K., Liu T.C., Sweeney G.A.R.Y., Zhou M. and Wang Y., Protection from obesity-induced insulin resistance in mice lacking lipocalin-2 , Fourth International Symposium on Healthy Aging. 2009.

Liu T.C., Xu A., Man R.Y.K., Vanhoutte P.M.G.R., Mak T...W..., Law K.M. and Wang Y., Lipocalin-2 deficiency attenuates endothelial dysfunction associated with aging and obesity, Fourth International Symposium on Healthy Aging of Research Centre of Heart, Brain, Hormone & Healthy Aging, March 7-8, 2009, Hong Kong. 2009.

Researcher : Law KM

List of Research Outputs

Researcher : Lee MYK

List of Research Outputs

Lee M.Y.K., Vanhoutte P.M.G.R. and Xu A., Adipocyte-fatty acid binding protein (A-FABP) is present in the endothelium of male apolipoprotein E-knockout mice, Twelfth Annual Scientific Meeting of Institute of Cardiovascular Science and Medince, December 13-14, 2008, Hong Kong. 2008.

Lee M.Y.K., Tse H.F., Wang Y. and Vanhoutte P.M.G.R., Gender differences in the genomic changes in cultures derived from procine regenerated coronary endothelial cells fed with a high cholesterol diet, Fourth International Symposium on Healthy Aging of Research Centre of Heart, Brain, Hormone & Healthy Aging, March 7-8, 2009, Hong Kong. 2009.

Lee M.Y.K., Vanhoutte P.M.G.R. and Xu A., Pharmacological inhibition of adipocyte-fatty acid binding protein (A-FABP) improves endothelial function in male apolipoprotein e-knockout mice, International Symposium on Mechanisms of Vasodilatation. Matsushima, Miyagi, Japan. 01-03 Jun 2009.

Lee M.Y.K., Sørensen G.R.I.T.H. .L., Holmskov U.F.F.E. and Vanhoutte P.M.G.R., The presence and activity of SP-D in porcine coronary endothelial cells depend on Akt/PI3K, Erk and nitric oxide and decrease after multiple passaging, Molecular Immunology. 2008, 46: 1050.

Wang Y., Zu Y., Liu L., Lam K.S.L., Lee M.Y.K., Vanhoutte P.M.G.R. and Xu A., SIRT1 promotes cell proliferation and prevents cellular senescence through targeting LKB1 in primary cultures of porcine aortic endothelial cells, 10th International Symposium on Mechanisms of Vasodilatation. 2009.

Zu Y., Liu L., Xu A., Lee M.Y.K., Lam K.S.L., Vanhoutte P.M.G.R. and Wang Y., SIRT1 promotes cell proliferation and prevents cellularr senescence in primary porcine endothelial cells, Fourth International Symposium on Healthy Aging of Research Centre of Heart, Brain, Hormone & Healthy Aging, March 7-8, 2009, Hong Kong. 2009.

Researcher : Leung GPH

List of Research Outputs

Govindarajan R., Leung G.P.H., Zhou M., Tse C.M., Wang J. and Unadkat J.D., Facilitated Mitochondrial Import of Anti-viral and Anti-cancer Nucleoside Drugs by Human Equilibrative Nucleoside Transporter-3 (hENT3), American Journal of Physiology Gastrointestinal and Liver Physiology . 2009, 296: G910-922.

Ho Y.W., Leung G.P.H., Man R.Y.K., Vanhoutte P.M.G.R. and Ng J.K.F., Distributions of alpha 2 adrenoceptor subtypes in porcine coronary vasculature. San Diego, 5-9 Apr , Experimental Biology . 2008.

Ho Y.W., Leung G.P.H., Man R.Y.K., Vanhoutte P.M.G.R. and Ng J.K.F., Distributions of alpha 2 adrenoceptor subtypes in porcine coronary vasculature, FASEB Journal. 2008, 22: 914.10.

Ho Y.W., Li W.S.R., Vanhoutte P.M.G.R., Man R.Y.K., Leung S.W.S. and Leung G.P.H., Possible role of organic cation transport-3 in serotonin uptake in human brain vascular smooth muscle cells, 10th International Symposium on Mechanisms of Vasodilatation 2009.

Ho Y.W., Li W.S.R., Vanhoutte P.M.G.R., Man R.Y.K., Leung S.W.S. and Leung G.P.H., Possible role of organic cation transpporter-3 in serotonin uptake in human brain vascular smooth muscle cells, Journal of vascular research . 2009, 46 supp 1: 202.

Leung G.P.H., Ho Y.W., Li W.S.R., Seto S.W. and Kwan Y.W., Diabetes- and hypertension-induced upregulation of concentrative nucleoside transporter-2 in endothelial cells, Journal of Vascular Research. 2009, 46 (Supp 1): 178.

Leung G.P.H., Li R.W.S., Seto S...W... and Kwan Y...W..., Inhibitory effects of non-steroidal anti-inflammatory drugs (NSAIDS) on nucleoside transporters in human aortic smooth muscle cells, Twelfth Annual Scientific Meeting of Institute of Cardiovascular Science and Medince, December 13-14, 2008, Hong Kong. 2008.

Leung I.C.Y., Vanhoutte P.M.G.R., Man R.Y.K. and Leung G.P.H., Tissue-type plasminogen activator: A possible candidate of endothelium-derved hyperpolarization factor?, Twelfth Annual Scientific Meeting of Institute of Cardiovascular Science and Medince, December 13-14, 2008, Hong Kong. 2008.

Leung I.C.Y., Vanhoutte P.M.G.R., Man R.Y.K. and Leung G.P.H., Tissue-type plasminogen activator: a possible candidate of endothelium-derived hyperpolarization factor?, 13th Research Postgraduate Symposium, December 10-11, 2008.

Leung S.W.S., Ho Y.W., Man G.S.K., Leung G.P.H. and Man R.Y.K., Role of extracellular signal-related kinases in the pathophysiology of vascular dysfunction in aging and hypertension, 10th International Symposium on Mechanisms of Vasodilatation 2009 . 2009.

Leung S.W.S., Ho Y.W., Man G.S.K., Leung G.P.H. and Man R.Y.K., Role of extracellular signal-related kinases in the pathophysiology of vascular dysfunction in aging and hypertension, Journal of Vascular Reseach. 2009, 46 (supp 1): 110.

Li R.W.S. and Leung G.P.H., Effect of 2',3'-dideoxyadenosine on the relaxation of rat basilar arteries, Twelfth Annual Scientific Meeting of Institute of Cardiovascular Science and Medince, December 13-14, 2008, Hong Kong. 2008.

Li R.W.S. and Leung G.P.H., Effects of antiviral nucleoside analogs on relaxation of rat basilar arteries, 10th International Symposium on Mechanisms of Vasodilatation, Matsushima, Miyagi, Japan, June 1-3, 2009.

Li R.W.S., Kwan Y...W... and Leung G.P.H., Vasoactivity of rat basilar arteries in response to antiviral nucleoside analogs, Twelfth Scientific Meeting of Hong Kong Pharmacology Society, June 12-15, 2009, Hong Kong. 2009.

Li W.S.R. and Leung G.P.H., Effects of antiviral nucleoside analogs on relaxation of rat basilar arteries, Journal of Vascular Research. 2009, 46 (Supp 1): 114.

Li W.S.R., Seto S.W., Au A.L.S., Kwan Y.W., Tse C.M. and Leung G.P.H., Inhibitory effect of nonsteroidal anti-inflammatory drugs on adenosine transport in vascular smooth muscle cells, European Journal of Pharmacology. 2009, 612: 15-20.

Li W.S.R., Man R.Y.K., Vanhoutte P.M.G.R. and Leung G.P.H., Stimulation of ecto-5'nucleotidase in human umbilical vein endothelial cells by lipopolysaccharide, American Journal of Physiology Heart and Circulation Physiology. 2008.

Lin A.H.Y., Leung G.P.H., Leung S.W.S. and Man R.Y.K., Genistein acutely potentiates acetylcholine-induced relaxation through a G-protein coupled pathway in spontaneously hypertensive rats, Twelfth Annual Scientific Meeting of Institute of Cardiovascular Science and Medince, December 13-14, 2008, Hong Kong. 2008.

Lin H.Y.A., Leung G.P.H., Leung S.W.S. and Man R.Y.K., Genistein acutely potentiates acetylcholine-induced relaxation through a G-protein coupled pathway in spontaneously hypertensive rats, Journal of the Hong Kong College of Cardiology/The 12th Annual Scientific Meeting, Institute of Cardiovascular Science and Medicine, The University of Hong Kong . 2008, 16: 59.

Lin H.Y.A., Leung G.P.H., Leung S.W.S. and Man R.Y.K., Rapid, non-genomic vascular action of genistein suggests a putative G-protein coupled phytoestrogen receptor, The 3rd Scientific Meeting of The Asian Society for Vascular Biology, Singapore, August 4-5, 2008 . 2008, 42.

Lin H.Y.A., Leung G.P.H., Leung S.W.S. and Man R.Y.K., Rapid, non-genomic vascular actions of genistein involves a G-protein coupled receptor, 10th International Symposium on Mechanisms of Vasodilatation 2009 . 2009.

Lin H.Y.A., Leung G.P.H., Leung S.W.S. and Man R.Y.K., Rapid, non-genomic vascular actions of genistein involves a G-protein coupled receptor, journal of vascular research. 2009, 46 (supp 1): 187.

Ng J.K.F., Leung G.P.H., Ho Y.W., Man R.Y.K. and Vanhoutte P.M.G.R., Dexmedetomidine relaxes isolated porcine coronary artery via endothelial 2A receptors, Annual Meeting of the American Society of Anaesthesioogists, Orlando, 18-22 Oct. 2008.

Ng W.W.H., Keung W.W.Y., Xu Y., Ng J.K.F., Leung G.P.H., Vanhoutte P.M.G.R., Choy P.C. and Man R.Y.K., Genistein otentiates protein kinase A activity in porcine coronary artery, Mol Cell Biochem. 2008, 311: 37-44.

Seto S.W., Lam T.Y., Tam H.L., Au L.S., Lam T.Y., Chan S.W., Wu J.H., Yu P.H., Leung G.P.H., Ngai S.M., Yeung J.H., Leung P.S., Lee S.M. and Kwan Y.W., Novel hypoglycemic effects of Ganoderma lucidum water-extract in obese/diabetic (+db/+db) mice, Phytomedicine. 2009, 16: 426-436.

Seto S.W., Lam H.Y., Lau W.S., Au A.L., Lam T.Y., Chim S.S., Ngai S.M., Chan S.W., Leung T.Y., Yeung J.H., Kong S.K., Leung G.P.H., Lee S.M. and Kwan Y.W., Role of monoamine oxidases in the exaggerated 5-hydroxytryptamine-induced tension development of human isolated preeclamptic umbilical artery, European Journal of Pharmacology . 2009, 605: 129-137.

Wat C.Y., Yuen M.K., Li W.S.R., Leung G.P.H. and Ng J.K.F., Lipid emulsion vs standard cardiac resuscitation in ropivacaine toxicity in pigs, ANZCA ASM 2009.

Yang C., Kwan Y.W., Seto S.W. and Leung G.P.H., Inhibitory effects of epoxyeicosatrienoic acids on volume-activated chloride channels in rat mesenteric arterial smooth muscle, Prostaglandins and Other Lipid Mediator . 2008, 87: 62-67.

Researcher : Leung ICY

List of Research Outputs

Leung I.C.Y., Vanhoutte P.M.G.R., Man R.Y.K. and Leung G.P.H., Tissue-type plasminogen activator: A possible candidate of endothelium-derved hyperpolarization factor?, Twelfth Annual Scientific Meeting of Institute of Cardiovascular Science and Medince, December 13-14, 2008, Hong Kong. 2008.

Leung I.C.Y., Vanhoutte P.M.G.R., Man R.Y.K. and Leung G.P.H., Tissue-type plasminogen activator: a possible candidate of endothelium-derived hyperpolarization factor?, 13th Research Postgraduate Symposium, December 10-11, 2008.

Researcher : Leung SWS

List of Research Outputs

Ho Y.W., Li W.S.R., Vanhoutte P.M.G.R., Man R.Y.K., Leung S.W.S. and Leung G.P.H., Possible role of organic cation transport-3 in serotonin uptake in human brain vascular smooth muscle cells, 10th International Symposium on Mechanisms of Vasodilatation 2009.

Ho Y.W., Li W.S.R., Vanhoutte P.M.G.R., Man R.Y.K., Leung S.W.S. and Leung G.P.H., Possible role of organic cation transpporter-3 in serotonin uptake in human brain vascular smooth muscle cells, Journal of vascular research . 2009, 46 supp 1: 202.

Keung W.Y.W., Chan M.L.Y., Vanhoutte P.M.G.R., Leung S.W.S. and Man R.Y.K., The effect of 17b-estradiol on adenylyl cyclase and protein kinase G in the regulation of vascular tone, 10th International Symposium on Mechanisms of Vasodilatation 2009 . 2009.

Kong B.W.C., Man R.Y.K., Vanhoutte P.M.G.R. and Leung S.W.S., Hypertension and EDHF-mediated responses in mesenteric arteries of the rats, 10th International Symposium on Mechanisms of Vasodilatation, Matsushima, Miyagi, Japan, June 1-3, 2009.

Kong W.C.B., Man R.Y.K., Vanhoutte P.M.G.R. and Leung S.W.S., Aging and hypertension attenuate relaxations due to endothelium-derived hyperpolarizing factor in the rat superior mesenteric artery , 10th International Symposium on Mechanisms of Vasodilatation 2009 . 2009.

Kong W.C.B., Leung S.W.S., Man R.Y.K. and Vanhoutte P.M.G.R., The effect of aging and hypertension on endothelial-derived hyperpolarizing factor (EDHF)-mediated responses in spontaneously hypertensive rats, Journal of the Hong Kong College of Cardiology, 2008/ The 12th Annual Scientific Meeting, Institute of Cardiovascular Science and Medicine, The University of Hong Kong . 2008, 16: 63.

Leung S.W.S., Ho Y.W., Man G.S.K., Leung G.P.H. and Man R.Y.K., Role of extracellular signal-related kinases in the pathophysiology of vascular dysfunction in aging and hypertension, 10th International Symposium on Mechanisms of Vasodilatation 2009 . 2009.

Leung S.W.S., Ho Y.W., Man G.S.K., Leung G.P.H. and Man R.Y.K., Role of extracellular signal-related kinases in the pathophysiology of vascular dysfunction in aging and hypertension, Journal of Vascular Reseach. 2009, 46 (supp 1): 110.

Liang C., Leung S.W.S., Ng J.K.F., Feletou M., Man R.Y.K. and Vanhoutte P.M.G.R., Endothelium-derived NO inhibits the relaxation to C-type natriuretic peptide (CNP) in porcine coronary arteries, Twelfth Scientific Meeting of Hong Kong Pharmacology Society, June 12-15, 2009, Hong Kong. 2009.

Liang C., Leung S.W.S., Ng J.K.F., Man R.Y.K., Feletou M. and Vanhoutte P.M.G.R., Endothelium-derived nitric oxide inhibits CNP-induced relaxation in the isolated porcine coronary artery, 10th International Symposium on Mechanisms of Vasodilatation 2009 . 2009.

Liang C., Leung S.W.S., Ng J.K.F., Man R.Y.K. and Vanhoutte P.M.G.R., Inhibition of the relaxation to CNP by endothelium-derived nitric oxide in the porcine coronary artery, Journal of the Hong Kong College of Cardiology, 2008/ The 12th Annual Scientific Meeting, Institute of Cardiovascular Science and Medicine, The University of Hong Kong . 2008, 16: 64.

Liang C., Leung S.W.S., Ng J.K.F., Man R.Y.K., Feletou M. and Vanhoutte P.M.G.R., The inhibition of endothelium-derived nitric oxide on CNP-induced relaxation in the isolated porcine coronary artery, Fourth International Symposium on Healthy Aging of Research Centre of Heart, Brain, Hormone & Healthy Aging, March 7-8, 2009, Hong Kong. 2009.

Liang C., Leung S.W.S., Ng J.K.F., Man R.Y.K., Feletou M. and Vanhoutte P.M.G.R., The inhibition of endothelium-derived nitric oxide on CNP-induced relaxation in the isolated porcine coronary artery, Fourth International Symposium on Healthy Aging: Emerging Therapies for an Aging Population. 2009.

Liang S.C., Leung S.W.S., Ng J.K.F., Man R.Y.K., Feletou M. and Vanhoutte P.M.G.R., Endothelium-derived nitric oxide inhibites CNP-induced relaxation in the isolated porcine coronary artery, Mechanism of Vasodilatation MOVD 2009, Matsushima, 1-3 June. 2009.

Lin A.H.Y., Leung G.P.H., Leung S.W.S. and Man R.Y.K., Genistein acutely potentiates acetylcholine-induced relaxation through a G-protein coupled pathway in spontaneously hypertensive rats, Twelfth Annual Scientific Meeting of Institute of Cardiovascular Science and Medince, December 13-14, 2008, Hong Kong. 2008.

Lin H.Y.A., Leung G.P.H., Leung S.W.S. and Man R.Y.K., Genistein acutely potentiates acetylcholine-induced relaxation through a G-protein coupled pathway in spontaneously hypertensive rats, Journal of the Hong Kong College of Cardiology/The 12th Annual Scientific Meeting, Institute of Cardiovascular Science and Medicine, The University of Hong Kong . 2008, 16: 59.

Lin H.Y.A., Leung G.P.H., Leung S.W.S. and Man R.Y.K., Rapid, non-genomic vascular action of genistein suggests a putative G-protein coupled phytoestrogen receptor, The 3rd Scientific Meeting of The Asian Society for Vascular Biology, Singapore, August 4-5, 2008 . 2008, 42.

Lin H.Y.A., Leung G.P.H., Leung S.W.S. and Man R.Y.K., Rapid, non-genomic vascular actions of genistein involves a G-protein coupled receptor, 10th International Symposium on Mechanisms of Vasodilatation 2009 . 2009.

Lin H.Y.A., Leung G.P.H., Leung S.W.S. and Man R.Y.K., Rapid, non-genomic vascular actions of genistein involves a G-protein coupled receptor, journal of vascular research. 2009, 46 (supp 1): 187.

Ng J.K.F., Leung S.W.S., Man R.Y.K. and Vanhoutte P.M.G.R., C-type natriuretic peptide (CNP) release does not contribute to endothelium-derived hyperpolarizing factor (EDHF) mediated relaxation inporcine coronary artery, FASEB Journal. 2008, 22: 914.3.

Ng J.K.F., Leung S.W.S., Man R.Y.K. and Vanhoutte P.M.G.R., C-type natriuretic petide (CNP) release does not contribute to endothelium -derived hyperpolarizing factor (EDHF) medicated relaxation in porcine coronary artery. San Diego, 5-9 Apr , Experimental Biology 2008.

Ng J.K.F., Tsang S.F., Leung S.W.S., Tang W.M. and Chiu P.K.Y., Coagulation, blood loss and platelet activation during geeral anaesthesia with isoflurane or sevoflurane, Annual Meeting of the American Society of Anesthesiologists, Orlando, 18-22 Oct. 2008.

Ng J.K.F., Tsang S.F., Leung S.W.S., Tang W.M. and Chiu P.K.Y., Coagulation, blood loss and platelet activation during isoflurane or sevolfurane anaesthesia, Anesthesiology. 2008, 109: A1619.

Ng J.K.F., Leung S.W.S., Man R.Y.K. and Vanhoutte P.M.G.R., EDHF-mediated relaxations in pig coronary arteries do not involve Gi/o proteins, Acta Pharmacol Sin. 2008, 29: 1419-1424.

Ng J.K.F., Leung S.W.S., Man R.Y.K. and Vanhoutte P.M.G.R., Endothelium-derived hyperpolarizing factor mediated relaxations in porcine coronary arteries do not involve Gi/o proteins, Acta Pharmacologica Sinica. 2008, 29: 1419-1424.

Qu C., Leung S.W.S., Vanhoutte P.M.G.R. and Man R.Y.K., Effect of PPAR agonists on relaxations and contractions of the SHR aorta, 10th International Symposium on Mechanisms of Vasodilatation 2009.

Qu C., Leung S.W.S., Vanhoutte P.M.G.R. and Man R.Y.K., Effect of PPAR agonists on relaxations and contractions of the SHR aorta, Twelfth Scientific Meeting of Hong Kong Pharmacology Society, June 12-15, 2009, Hong Kong. 2009.

Teoh H., Quan A., Leung S.W.S. and Man R.Y.K., Vascular effects of estrone and diethylstilbestrol in porcine coronary arteries, Menopause . North American Menopause Society, 2009, 16: 104-109.

Wan A.K.S., Leung S.W.S., Zhu D. and Man R.Y.K., Vascular effects of different lipophilic components of “danshen”, a traditional Chinese medicine, in the isolated porcine coronary artery, Journal of Natural Products. 2008, 71: 1825-1828.

Researcher : Li RWS

List of Research Outputs

Leung G.P.H., Li R.W.S., Seto S...W... and Kwan Y...W..., Inhibitory effects of non-steroidal anti-inflammatory drugs (NSAIDS) on nucleoside transporters in human aortic smooth muscle cells, Twelfth Annual Scientific Meeting of Institute of Cardiovascular Science and Medince, December 13-14, 2008, Hong Kong. 2008.

Li R.W.S. and Leung G.P.H., Effect of 2',3'-dideoxyadenosine on the relaxation of rat basilar arteries, Twelfth Annual Scientific Meeting of Institute of Cardiovascular Science and Medince, December 13-14, 2008, Hong Kong. 2008.

Li R.W.S. and Leung G.P.H., Effects of antiviral nucleoside analogs on relaxation of rat basilar arteries, 10th International Symposium on Mechanisms of Vasodilatation, Matsushima, Miyagi, Japan, June 1-3, 2009.

Li R.W.S., Kwan Y...W... and Leung G.P.H., Vasoactivity of rat basilar arteries in response to antiviral nucleoside analogs, Twelfth Scientific Meeting of Hong Kong Pharmacology Society, June 12-15, 2009, Hong Kong. 2009.

Researcher : Li WSR

List of Research Outputs

Ho Y.W., Li W.S.R., Vanhoutte P.M.G.R., Man R.Y.K., Leung S.W.S. and Leung G.P.H., Possible role of organic cation transport-3 in serotonin uptake in human brain vascular smooth muscle cells, 10th International Symposium on Mechanisms of Vasodilatation 2009.

Ho Y.W., Li W.S.R., Vanhoutte P.M.G.R., Man R.Y.K., Leung S.W.S. and Leung G.P.H., Possible role of organic cation transpporter-3 in serotonin uptake in human brain vascular smooth muscle cells, Journal of vascular research . 2009, 46 supp 1: 202.

Leung G.P.H., Ho Y.W., Li W.S.R., Seto S.W. and Kwan Y.W., Diabetes- and hypertension-induced upregulation of concentrative nucleoside transporter-2 in endothelial cells, Journal of Vascular Research. 2009, 46 (Supp 1): 178.

Li W.S.R. and Leung G.P.H., Effects of antiviral nucleoside analogs on relaxation of rat basilar arteries, Journal of Vascular Research. 2009, 46 (Supp 1): 114.

Li W.S.R., Seto S.W., Au A.L.S., Kwan Y.W., Tse C.M. and Leung G.P.H., Inhibitory effect of nonsteroidal anti-inflammatory drugs on adenosine transport in vascular smooth muscle cells, European Journal of Pharmacology. 2009, 612: 15-20.

Li W.S.R., Man R.Y.K., Vanhoutte P.M.G.R. and Leung G.P.H., Stimulation of ecto-5'nucleotidase in human umbilical vein endothelial cells by lipopolysaccharide, American Journal of Physiology Heart and Circulation Physiology. 2008.

Wat C.Y., Yuen M.K., Li W.S.R., Leung G.P.H. and Ng J.K.F., Lipid emulsion vs standard cardiac resuscitation in ropivacaine toxicity in pigs, ANZCA ASM 2009.

Researcher : Li Z

List of Research Outputs

Li Z., Koo M.W.L., Wang Y. and Vanhoutte P.M.G.R., Epigallocatechin gallate causes endothelium dependent contractions in the rat aorta, 10th International Symposium on Mechanisms of Vasodilatation, Matsushima, Miyagi, Japan, June 1-3, 2009.

Li Z., Koo M.W.L., Wang Y. and Vanhoutte P.M.G.R., Epigllocatechin gallate induces contractions of the rats aorta due to production of reactive oxygen species, activation of cyclooxygenase and stimulation of thromboxane-prostanoid receptor, Twelfth Scientific Meeting of Hong Kong Pharmacology Society, June 12-15, 2009 Hong Kong. 2009.

Researcher : Liang C

List of Research Outputs

Liang C., Leung S.W.S., Ng J.K.F., Feletou M., Man R.Y.K. and Vanhoutte P.M.G.R., Endothelium-derived NO inhibits the relaxation to C-type natriuretic peptide (CNP) in porcine coronary arteries, Twelfth Scientific Meeting of Hong Kong Pharmacology Society, June 12-15, 2009, Hong Kong. 2009.

Liang C., Leung S.W.S., Ng J.K.F., Man R.Y.K., Feletou M. and Vanhoutte P.M.G.R., Endothelium-derived nitric oxide inhibits CNP-induced relaxation in the isolated porcine coronary artery, 10th International Symposium on Mechanisms of Vasodilatation 2009 . 2009.

Liang C., Leung S.W.S., Ng J.K.F., Man R.Y.K. and Vanhoutte P.M.G.R., Inhibition of the relaxation to CNP by endothelium-derived nitric oxide in the porcine coronary artery, Journal of the Hong Kong College of Cardiology, 2008/ The 12th Annual Scientific Meeting, Institute of Cardiovascular Science and Medicine, The University of Hong Kong . 2008, 16: 64.

Liang C., Leung S.W.S., Ng J.K.F., Man R.Y.K., Feletou M. and Vanhoutte P.M.G.R., The inhibition of endothelium-derived nitric oxide on CNP-induced relaxation in the isolated porcine coronary artery, Fourth International Symposium on Healthy Aging of Research Centre of Heart, Brain, Hormone & Healthy Aging, March 7-8, 2009, Hong Kong. 2009.

Liang C., Leung S.W.S., Ng J.K.F., Man R.Y.K., Feletou M. and Vanhoutte P.M.G.R., The inhibition of endothelium-derived nitric oxide on CNP-induced relaxation in the isolated porcine coronary artery, Fourth International Symposium on Healthy Aging: Emerging Therapies for an Aging Population. 2009.

Researcher : Liang C

List of Research Outputs

Liang C., Leung S.W.S., Ng J.K.F., Man R.Y.K., Feletou M. and Vanhoutte P.M.G.R., The inhibition of endothelium-derived nitric oxide on CNP-induced relaxation in the isolated porcine coronary artery, Fourth International Symposium on Healthy Aging: Emerging Therapies for an Aging Population. 2009.

Researcher : Lin AHY

List of Research Outputs

Lin A.H.Y., Leung G.P.H., Leung S.W.S. and Man R.Y.K., Genistein acutely potentiates acetylcholine-induced relaxation through a G-protein coupled pathway in spontaneously hypertensive rats, Twelfth Annual Scientific Meeting of Institute of Cardiovascular Science and Medince, December 13-14, 2008, Hong Kong. 2008.

Researcher : Lin HYA

List of Research Outputs

Lin H.Y.A., Leung G.P.H., Leung S.W.S. and Man R.Y.K., Genistein acutely potentiates acetylcholine-induced relaxation through a G-protein coupled pathway in spontaneously hypertensive rats, Journal of the Hong Kong College of Cardiology/The 12th Annual Scientific Meeting, Institute of Cardiovascular Science and Medicine, The University of Hong Kong . 2008, 16: 59.

Lin H.Y.A., Leung G.P.H., Leung S.W.S. and Man R.Y.K., Rapid, non-genomic vascular action of genistein suggests a putative G-protein coupled phytoestrogen receptor, The 3rd Scientific Meeting of The Asian Society for Vascular Biology, Singapore, August 4-5, 2008 . 2008, 42.

Lin H.Y.A., Leung G.P.H., Leung S.W.S. and Man R.Y.K., Rapid, non-genomic vascular actions of genistein involves a G-protein coupled receptor, 10th International Symposium on Mechanisms of Vasodilatation 2009 . 2009.

Lin H.Y.A., Leung G.P.H., Leung S.W.S. and Man R.Y.K., Rapid, non-genomic vascular actions of genistein involves a G-protein coupled receptor, journal of vascular research. 2009, 46 (supp 1): 187.

Researcher : Liu J

List of Research Outputs

Lam J.B.B., Chow H.M., Xu A., Lam K.S.L., Liu J., Moon R.T., Shepherd P.R., Cooper G.J. and Wang Y., Adiponectin haploinsufficiency promotes mammary tumor development in MMTV-PyVT mice by modulation of phosphatase and tensin homolog activities., PLoS ONE. 2009, 4: e4968.

Liu J., Lam J.B.B., Chow H.M., Xu A., Lam K.S.L., Randall T. and Wang Y., Adiponectin stimulates Wnt inhibitory factor-1 expression through epigenetic regulations involving the transcription factor specificity protein 1, Carcinogenesis . 2008, 31: 1889-91.

Zhou M., Xu A., Tam P.K.H., Lam K.S.L., Chan L., Hoo R.L.C., Liu J., Chow H.M. and Wang Y., Mitochondrial dysfunction contributes to the increased vulnerabilities of adiponectin knockout mice to liver injury., Hepatology. 2008, 48 (4): 1087-96.

Zhou M., Xu A., Tam P.K.H., Lam K.S.L., Chan L., Liu J., Chow H.M. and Wang Y., Mitochondrial dysfunction contributes to the increased vulnerabilities of adiponectin knockout mice to liver injury, Fourth International Symposium on Healthy Aging: "Emerging Therapies for an Aging Population". 2009.

Researcher : Liu J

List of Research Outputs

Researcher : Liu TC

List of Research Outputs

Law K.M., Xu A., Lam K.S.L., Liu T.C., Berger T., Mak T...W..., Zhang M...X...M... and Wang Y., Mice lacking lipicalin-2 show increased insulin sensitivity and are resistant to high fat diet- and genetic obesity-induced insulin resistance and diabetes, 13th Research Postgraduate Symposium, December 10-11, 2008.

Law K.M., Xu A., Lam K.S.L., Berger T.H.O.R.S.T.E.N., Mak T.A.K., Liu T.C., Sweeney G.A.R.Y., Zhou M. and Wang Y., Protection from obesity-induced insulin resistance in mice lacking lipocalin-2 , Fourth International Symposium on Healthy Aging. 2009.

Liu T.C., Xu A., Man R.Y.K., Vanhoutte P.M.G.R., Mak T.A.K. and Wang Y., Absence of lipocalin-2 prevents endothelium-dependent contractions induced by aging and high fat diet feeding in mice, 10th International Symposium on Mechanisms of Vasodilatation. 2009.

Liu T.C., Xu A., Man R.Y.K., Vanhoutte P.M.G.R., Mak T...W..., Law K.M. and Wang Y., Lipocalin-2 deficiency attenuates endothelial dysfunction associated with aging and obesity, Fourth International Symposium on Healthy Aging of Research Centre of Heart, Brain, Hormone & Healthy Aging, March 7-8, 2009, Hong Kong. 2009.

Researcher : Liu TC

List of Research Outputs

Researcher : Mak JCW

List of Research Outputs

Chan C.K.Y., Mak J.C.W., Man R.Y.K. and Vanhoutte P.M.G.R., Contractile response to hypoxia in the porcine coronary artery, Twelfth Annual Scientific Meeting of Institute of Cardiovascular Science and Medince, December 13-14, 2008, Hong Kong. 2008.

Chan C.K.Y., Vanhoutte P.M.G.R., Man R.Y.K. and Mak J.C.W., Nitric oxide synthase and soluble guanylyl cyclase activation are required for hypoxic endothelium-dependent contractions of the porcine coronary artery, 10th International Symposium on Mechanisms of Vasodilatation, Matsushima, Miyagi, Japan, June 1-3, 2009.

Chan C.K.Y., Mak J.C.W., Man R.Y.K. and Vanhoutte P.M.G.R., Nitric oxide synthase and soluble guanylyl cyclase activation are required for hypoxic endothelium-dependent contractions of the porcine coronary artery, Twelfth Scientific Meeting of Hong Kong Pharmacology Society, June 12-15, 2009, Hong Kong. 2009.

Chan C.K.Y., Mak J.C.W., Man R.Y.K. and Vanhoutte P.M.G.R., Rho kinase inhibitors prevent endothelium-dependent contractions in the rat aorta, Fourth International Symposium on Healthy Aging of Research Centre of Heart, Brain, Hormone & Healthy Aging, March 7-8, 2009, Hong Kong. 2009.

Chan C.K.Y., Vanhoutte P.M.G.R., Man R.Y.K. and Mak J.C.W., Rho kniase inhibitors prevent endothelium-dependent contractions in the rats aorta, 10th International Symposium on Mechanisms of Vasodilatation, Matsushima, Miyagi, Japan, June 1-3, 2009.

Researcher : Man GSK

List of Research Outputs

Leung S.W.S., Ho Y.W., Man G.S.K., Leung G.P.H. and Man R.Y.K., Role of extracellular signal-related kinases in the pathophysiology of vascular dysfunction in aging and hypertension, 10th International Symposium on Mechanisms of Vasodilatation 2009 . 2009.

Leung S.W.S., Ho Y.W., Man G.S.K., Leung G.P.H. and Man R.Y.K., Role of extracellular signal-related kinases in the pathophysiology of vascular dysfunction in aging and hypertension, Journal of Vascular Reseach. 2009, 46 (supp 1): 110.

Michel F...S..., Man G.S.K., Man R.Y.K. and Vanhoutte P.M.G.R., Hypertension and the absence of EDHF-mediated responses favor endothelium-dependent contractions in renal arteries of the rat, British Journal of Pharmacology. 2008, 2008, 13: 4198-4217.

Researcher : Man RYK

List of Research Outputs

Chan C.K.Y., Man R.Y.K. and Vanhoutte P.M.G.R., Contractile response to hypoxia in the porcine coronary artery, 13th Research Postgraduate Symposium, December 10-11, 2008.

Chan C.K.Y., Mak J.C.W., Man R.Y.K. and Vanhoutte P.M.G.R., Contractile response to hypoxia in the porcine coronary artery, Twelfth Annual Scientific Meeting of Institute of Cardiovascular Science and Medince, December 13-14, 2008, Hong Kong. 2008.

Chan C.K.Y., Vanhoutte P.M.G.R., Man R.Y.K. and Mak J.C.W., Nitric oxide synthase and soluble guanylyl cyclase activation are required for hypoxic endothelium-dependent contractions of the porcine coronary artery, 10th International Symposium on Mechanisms of Vasodilatation, Matsushima, Miyagi, Japan, June 1-3, 2009.

Chan C.K.Y., Mak J.C.W., Man R.Y.K. and Vanhoutte P.M.G.R., Nitric oxide synthase and soluble guanylyl cyclase activation are required for hypoxic endothelium-dependent contractions of the porcine coronary artery, Twelfth Scientific Meeting of Hong Kong Pharmacology Society, June 12-15, 2009, Hong Kong. 2009.

Chan C.K.Y., Mak J.C.W., Man R.Y.K. and Vanhoutte P.M.G.R., Rho kinase inhibitors prevent endothelium-dependent contractions in the rat aorta, Fourth International Symposium on Healthy Aging of Research Centre of Heart, Brain, Hormone & Healthy Aging, March 7-8, 2009, Hong Kong. 2009.

Chan C.K.Y., Vanhoutte P.M.G.R., Man R.Y.K. and Mak J.C.W., Rho kniase inhibitors prevent endothelium-dependent contractions in the rats aorta, 10th International Symposium on Mechanisms of Vasodilatation, Matsushima, Miyagi, Japan, June 1-3, 2009.

Chan K.H., Chan C.H., Ho S.P., Yeung S.C., Shum D.K.Y., Ip M.S.M., Man R.Y.K. and Mak J.C.W., Chinese green tea protects cigarette smoke-induced up-regulation of neutrophil elastase in rat lung, Am J Respir Crit Care Med. 2009, 179: A2022.

Chan K.H., Chan C.H., Ho S.P., Yeung S.C., Shum D.K.Y., Ip M.S.M., Man R.Y.K. and Mak J.C.W., Protection of cigarette smoke-induced up-regulation of neutrophil elastase by Chinese green tea in rat lung, 14th Medical Research Conference, Department of Medicine, HKU. Hong Kong Medical Journal. 2009, 15 (Supp 1): 8.

Chan K.Y.C., Mak J.C.W., Man R.Y.K. and Vanhoutte P.M.G.R., Rho kinase inhibitors prevent endothelium-dependent contractions in the rat aorta, J Pharmacol Exp Ther. 2009, 329: 820-826.

Ho Y.W., Leung G.P.H., Man R.Y.K., Vanhoutte P.M.G.R. and Ng J.K.F., Distributions of alpha 2 adrenoceptor subtypes in porcine coronary vasculature. San Diego, 5-9 Apr , Experimental Biology . 2008.

Ho Y.W., Leung G.P.H., Man R.Y.K., Vanhoutte P.M.G.R. and Ng J.K.F., Distributions of alpha 2 adrenoceptor subtypes in porcine coronary vasculature, FASEB Journal. 2008, 22: 914.10.

Ho Y.W., Li W.S.R., Vanhoutte P.M.G.R., Man R.Y.K., Leung S.W.S. and Leung G.P.H., Possible role of organic cation transport-3 in serotonin uptake in human brain vascular smooth muscle cells, 10th International Symposium on Mechanisms of Vasodilatation 2009.

Ho Y.W., Li W.S.R., Vanhoutte P.M.G.R., Man R.Y.K., Leung S.W.S. and Leung G.P.H., Possible role of organic cation transpporter-3 in serotonin uptake in human brain vascular smooth muscle cells, Journal of vascular research . 2009, 46 supp 1: 202.

Keung W.Y.W., Chan M.L.Y., Vanhoutte P.M.G.R., Leung S.W.S. and Man R.Y.K., The effect of 17b-estradiol on adenylyl cyclase and protein kinase G in the regulation of vascular tone, 10th International Symposium on Mechanisms of Vasodilatation 2009 . 2009.

Kong B.W.C., Man R.Y.K., Vanhoutte P.M.G.R. and Leung S.W.S., Hypertension and EDHF-mediated responses in mesenteric arteries of the rats, 10th International Symposium on Mechanisms of Vasodilatation, Matsushima, Miyagi, Japan, June 1-3, 2009.

Kong W.C.B., Man R.Y.K., Vanhoutte P.M.G.R. and Leung S.W.S., Aging and hypertension attenuate relaxations due to endothelium-derived hyperpolarizing factor in the rat superior mesenteric artery , 10th International Symposium on Mechanisms of Vasodilatation 2009 . 2009.

Kong W.C.B., Leung S.W.S., Man R.Y.K. and Vanhoutte P.M.G.R., The effect of aging and hypertension on endothelial-derived hyperpolarizing factor (EDHF)-mediated responses in spontaneously hypertensive rats, Journal of the Hong Kong College of Cardiology, 2008/ The 12th Annual Scientific Meeting, Institute of Cardiovascular Science and Medicine, The University of Hong Kong . 2008, 16: 63.

Leung I.C.Y., Vanhoutte P.M.G.R., Man R.Y.K. and Leung G.P.H., Tissue-type plasminogen activator: A possible candidate of endothelium-derved hyperpolarization factor?, Twelfth Annual Scientific Meeting of Institute of Cardiovascular Science and Medince, December 13-14, 2008, Hong Kong. 2008.

Leung I.C.Y., Vanhoutte P.M.G.R., Man R.Y.K. and Leung G.P.H., Tissue-type plasminogen activator: a possible candidate of endothelium-derived hyperpolarization factor?, 13th Research Postgraduate Symposium, December 10-11, 2008.

Leung S.W.S., Ho Y.W., Man G.S.K., Leung G.P.H. and Man R.Y.K., Role of extracellular signal-related kinases in the pathophysiology of vascular dysfunction in aging and hypertension, 10th International Symposium on Mechanisms of Vasodilatation 2009 . 2009.

Leung S.W.S., Ho Y.W., Man G.S.K., Leung G.P.H. and Man R.Y.K., Role of extracellular signal-related kinases in the pathophysiology of vascular dysfunction in aging and hypertension, Journal of Vascular Reseach. 2009, 46 (supp 1): 110.

Li W.S.R., Man R.Y.K., Vanhoutte P.M.G.R. and Leung G.P.H., Stimulation of ecto-5'nucleotidase in human umbilical vein endothelial cells by lipopolysaccharide, American Journal of Physiology Heart and Circulation Physiology. 2008.

Liang C., Leung S.W.S., Ng J.K.F., Feletou M., Man R.Y.K. and Vanhoutte P.M.G.R., Endothelium-derived NO inhibits the relaxation to C-type natriuretic peptide (CNP) in porcine coronary arteries, Twelfth Scientific Meeting of Hong Kong Pharmacology Society, June 12-15, 2009, Hong Kong. 2009.

Liang C., Leung S.W.S., Ng J.K.F., Man R.Y.K., Feletou M. and Vanhoutte P.M.G.R., Endothelium-derived nitric oxide inhibits CNP-induced relaxation in the isolated porcine coronary artery, 10th International Symposium on Mechanisms of Vasodilatation 2009 . 2009.

Liang C., Leung S.W.S., Ng J.K.F., Man R.Y.K. and Vanhoutte P.M.G.R., Inhibition of the relaxation to CNP by endothelium-derived nitric oxide in the porcine coronary artery, Journal of the Hong Kong College of Cardiology, 2008/ The 12th Annual Scientific Meeting, Institute of Cardiovascular Science and Medicine, The University of Hong Kong . 2008, 16: 64.

Liang C., Leung S.W.S., Ng J.K.F., Man R.Y.K., Feletou M. and Vanhoutte P.M.G.R., The inhibition of endothelium-derived nitric oxide on CNP-induced relaxation in the isolated porcine coronary artery, Fourth International Symposium on Healthy Aging of Research Centre of Heart, Brain, Hormone & Healthy Aging, March 7-8, 2009, Hong Kong. 2009.

Liang C., Leung S.W.S., Ng J.K.F., Man R.Y.K., Feletou M. and Vanhoutte P.M.G.R., The inhibition of endothelium-derived nitric oxide on CNP-induced relaxation in the isolated porcine coronary artery, Fourth International Symposium on Healthy Aging: Emerging Therapies for an Aging Population. 2009.

Liang S.C., Leung S.W.S., Ng J.K.F., Man R.Y.K., Feletou M. and Vanhoutte P.M.G.R., Endothelium-derived nitric oxide inhibites CNP-induced relaxation in the isolated porcine coronary artery, Mechanism of Vasodilatation MOVD 2009, Matsushima, 1-3 June. 2009.

Lin A.H.Y., Leung G.P.H., Leung S.W.S. and Man R.Y.K., Genistein acutely potentiates acetylcholine-induced relaxation through a G-protein coupled pathway in spontaneously hypertensive rats, Twelfth Annual Scientific Meeting of Institute of Cardiovascular Science and Medince, December 13-14, 2008, Hong Kong. 2008.

Lin H.Y.A., Leung G.P.H., Leung S.W.S. and Man R.Y.K., Genistein acutely potentiates acetylcholine-induced relaxation through a G-protein coupled pathway in spontaneously hypertensive rats, Journal of the Hong Kong College of Cardiology/The 12th Annual Scientific Meeting, Institute of Cardiovascular Science and Medicine, The University of Hong Kong . 2008, 16: 59.

Lin H.Y.A., Leung G.P.H., Leung S.W.S. and Man R.Y.K., Rapid, non-genomic vascular action of genistein suggests a putative G-protein coupled phytoestrogen receptor, The 3rd Scientific Meeting of The Asian Society for Vascular Biology, Singapore, August 4-5, 2008 . 2008, 42.

Lin H.Y.A., Leung G.P.H., Leung S.W.S. and Man R.Y.K., Rapid, non-genomic vascular actions of genistein involves a G-protein coupled receptor, 10th International Symposium on Mechanisms of Vasodilatation 2009 . 2009.

Lin H.Y.A., Leung G.P.H., Leung S.W.S. and Man R.Y.K., Rapid, non-genomic vascular actions of genistein involves a G-protein coupled receptor, journal of vascular research. 2009, 46 (supp 1): 187.

Liu T.C., Xu A., Man R.Y.K., Vanhoutte P.M.G.R., Mak T.A.K. and Wang Y., Absence of lipocalin-2 prevents endothelium-dependent contractions induced by aging and high fat diet feeding in mice, 10th International Symposium on Mechanisms of Vasodilatation. 2009.

Liu T.C., Xu A., Man R.Y.K., Vanhoutte P.M.G.R., Mak T...W..., Law K.M. and Wang Y., Lipocalin-2 deficiency attenuates endothelial dysfunction associated with aging and obesity, Fourth International Symposium on Healthy Aging of Research Centre of Heart, Brain, Hormone & Healthy Aging, March 7-8, 2009, Hong Kong. 2009.

Mak J.C.W., Chan K.H., Xu A., Ho S.P., Man R.Y.K., Lam K.S.L. and Ip M.S.M., Effects of cigarette smoke exposure on adiponectin levels in rats, 14th Medical Research Conference, Department of Medicine, HKU. Hong Kong Medical Journal. 2009, 15 (Supp 1): 28.

Mak J.C.W., Chan K.H., Xu A., Ho S.P., Man R.Y.K., Lam K.S.L. and Ip M.S.M., Effects of cigarette smoke exposure on adiponectin levels in rats, Am J Respir Crit Care Med. 2009, 179: A2029.

Man R.Y.K., Keung W.W.Y., Chan M.L.Y. and Vanhoutte P.M.G.R., The effect of the female hormone, 17b-Estradiol, on adenylyl cyclase and protein kinase G in the regulation of vascular function, 10th International Symposium on Mechanisms of Vasodilatation, Matsushima, Miyagi, Japan, June 1-3, 2009.

Michel F...S..., Man G.S.K., Man R.Y.K. and Vanhoutte P.M.G.R., Hypertension and the absence of EDHF-mediated responses favor endothelium-dependent contractions in renal arteries of the rat, British Journal of Pharmacology. 2008, 2008, 13: 4198-4217.

Ng J.K.F., Leung S.W.S., Man R.Y.K. and Vanhoutte P.M.G.R., C-type natriuretic peptide (CNP) release does not contribute to endothelium-derived hyperpolarizing factor (EDHF) mediated relaxation inporcine coronary artery, FASEB Journal. 2008, 22: 914.3.

Ng J.K.F., Leung S.W.S., Man R.Y.K. and Vanhoutte P.M.G.R., C-type natriuretic petide (CNP) release does not contribute to endothelium -derived hyperpolarizing factor (EDHF) medicated relaxation in porcine coronary artery. San Diego, 5-9 Apr , Experimental Biology 2008.

Ng J.K.F., Chan M.L.Y., Man R.Y.K. and Vanhoutte P.M.G.R., Dexmedetomidine relaxes isolated porcine coronary arteries by activating endothelial  2A, 2B and 2C adrenoceptors, Mechanism of Vasodilatation MOVD 2009.

Ng J.K.F., Chan M.L.Y., Man R.Y.K. and Vanhoutte P.M.G.R., Dexmedetomidine relaxes isolated porcine coronary arteries by activating enothelial a 2A, 2B and 2C adrenoceptors, Mechanism of Vasodilatation MOVD 2009, Matsushima. 2009.

Ng J.K.F., Leung G.P.H., Ho Y.W., Man R.Y.K. and Vanhoutte P.M.G.R., Dexmedetomidine relaxes isolated porcine coronary artery via endothelial 2A receptors, Annual Meeting of the American Society of Anaesthesioogists, Orlando, 18-22 Oct. 2008.

Ng J.K.F., Leung S.W.S., Man R.Y.K. and Vanhoutte P.M.G.R., EDHF-mediated relaxations in pig coronary arteries do not involve Gi/o proteins, Acta Pharmacol Sin. 2008, 29: 1419-1424.

Ng J.K.F., Leung S.W.S., Man R.Y.K. and Vanhoutte P.M.G.R., Endothelium-derived hyperpolarizing factor mediated relaxations in porcine coronary arteries do not involve Gi/o proteins, Acta Pharmacologica Sinica. 2008, 29: 1419-1424.

Ng W.W.H., Keung W.W.Y., Xu Y., Ng J.K.F., Leung G.P.H., Vanhoutte P.M.G.R., Choy P.C. and Man R.Y.K., Genistein otentiates protein kinase A activity in porcine coronary artery, Mol Cell Biochem. 2008, 311: 37-44.

Qu C., Leung S.W.S., Vanhoutte P.M.G.R. and Man R.Y.K., Effect of PPAR agonists on relaxations and contractions of the SHR aorta, 10th International Symposium on Mechanisms of Vasodilatation 2009.

Qu C., Leung S.W.S., Vanhoutte P.M.G.R. and Man R.Y.K., Effect of PPAR agonists on relaxations and contractions of the SHR aorta, Twelfth Scientific Meeting of Hong Kong Pharmacology Society, June 12-15, 2009, Hong Kong. 2009.

Sy L.K., Yan S.C., Lok C.N., Man R.Y.K. and Che C.M., Timosaponin A-III Indues Autophagy Preceding Mitochondria-Mediated Apoptosis in HeLa Cancer Cells , Cancer Research. 2008, 68: 10229 -10237.

Tang J., Feng Y., Tong Y., Yap M.M.L. and Man R.Y.K., A distinct new microscopic feature for identification of the crude drug of Radix Angelicae Pubescentis, In: Editoral Board of Journal of Chinese Medicinal Materials, Journal of Chinese Medicinal Materials. Guangzhou, Central Station of Chineses Medicinal Materials, SFDA, 2008, 31(12): 1796-1802.

Teoh H., Quan A., Leung S.W.S. and Man R.Y.K., Vascular effects of estrone and diethylstilbestrol in porcine coronary arteries, Menopause . North American Menopause Society, 2009, 16: 104-109.

Wan A.K.S., Leung S.W.S., Zhu D. and Man R.Y.K., Vascular effects of different lipophilic components of “danshen”, a traditional Chinese medicine, in the isolated porcine coronary artery, Journal of Natural Products. 2008, 71: 1825-1828.

Wong E.S.W., Man R.Y.K., Vanhoutte P.M.G.R. and Ng J.K.F., Differential effects of alpha-adrenoceptor agonists on relaxation in the mesenteric artery and aorta of the rat, Mechanism of Vasodilatation MOVD 2009, Matsushima, 1-3 June. 2009.

Wong E.S.W., Ng J.K.F., Man R.Y.K. and Vanhoutte P.M.G.R., Effects of dexmedetomidine in isolated arteries of pig and rat, 5th International EDFH Symposium, Tampere, 24-27 June. 2008.

Wong E.S.W., Man R.Y.K., Vanhoutte P.M.G.R. and Ng J.K.F., Effects of dexmedetomidine in the mesenteric artery and the aorta of the rat, 13th Research Postgraduate Symposium, December 10-11, 2008.

Wong E.S.W., Man R.Y.K., Vanhoutte P.M.G.R. and Ng J.K.F., Vascular effects of dexmedetomidine in isolated mesenteric artery and aorta of endotoxemic rat, 12th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, The University of Hong Kong, 13-14 Dec. 2008.

Wong J.Y.H., Tiwari A.F.Y., Fong D.Y.T., Chan E.K.L. and Man R.Y.K., Transition to parenthood: To understand expectant couple relationships, mental health and needs, the 13th Research Postgraduate Symposium, the University of Hong Kong, Hong Kong. 2008.

Wong S.K., Man R.Y.K. and Vanhoutte P.M.G.R., Calcium-independent phospholipase A2 involves in endothelium-dependent contractions in the aorta of the spontaneously hupertensive rats, Twelfth Annual Scientific Meeting of Institute of Cardiovascular Science and Medince, December 13-14, 2008, Hong Kong. 2008.

Wong S.K., Man R.Y.K. and Vanhoutte P.M.G.R., Calcium-independent phospholipase A2 is involved in endothelium-dependent contractions of the aorta of the spontaneously hypertensive rats, 10th International Symposium on Mechanisms of Vasodilatation, Matsushima, Miyagi, Japan, June 1-3, 2009.

Wong S.K., Man R.Y.K. and Vanhoutte P.M.G.R., Vitamin D derivatives acutely reduce endothelium-dependent contractions in the aorta of the spontaneously hypertensive rats, The 3rd Scientific Meeting of The Asian Society for Vascular Biology, Singapore, August 4-5, 2008. 29.

Wong S.W.E., Man R.Y.K., Vanhoutte P.M.G.R. and Ng J.K.F., Differential effects of alpha-adrenoceptor agonists on relaxation in the mesenteric artery and aorta of the rat., Mechanism of Vasodilatation MOVD 2009.

Researcher : Ng JKF

List of Research Outputs

Liang C., Leung S.W.S., Ng J.K.F., Man R.Y.K., Feletou M. and Vanhoutte P.M.G.R., Endothelium-derived nitric oxide inhibits CNP-induced relaxation in the isolated porcine coronary artery, 10th International Symposium on Mechanisms of Vasodilatation 2009 . 2009.

Liang C., Leung S.W.S., Ng J.K.F., Man R.Y.K. and Vanhoutte P.M.G.R., Inhibition of the relaxation to CNP by endothelium-derived nitric oxide in the porcine coronary artery, Journal of the Hong Kong College of Cardiology, 2008/ The 12th Annual Scientific Meeting, Institute of Cardiovascular Science and Medicine, The University of Hong Kong . 2008, 16: 64.

Liang C., Leung S.W.S., Ng J.K.F., Man R.Y.K., Feletou M. and Vanhoutte P.M.G.R., The inhibition of endothelium-derived nitric oxide on CNP-induced relaxation in the isolated porcine coronary artery, Fourth International Symposium on Healthy Aging: Emerging Therapies for an Aging Population. 2009.

Researcher : Ng WWH

List of Research Outputs

Ng W.W.H., Keung W.W.Y., Xu Y., Ng J.K.F., Leung G.P.H., Vanhoutte P.M.G.R., Choy P.C. and Man R.Y.K., Genistein otentiates protein kinase A activity in porcine coronary artery, Mol Cell Biochem. 2008, 311: 37-44.

Researcher : Qu C

List of Research Outputs

Qu C., Leung S.W.S., Vanhoutte P.M.G.R. and Man R.Y.K., Effect of PPAR agonists on relaxations and contractions of the SHR aorta, 10th International Symposium on Mechanisms of Vasodilatation 2009.

Qu C., Leung S.W.S., Vanhoutte P.M.G.R. and Man R.Y.K., Effect of PPAR agonists on relaxations and contractions of the SHR aorta, Twelfth Scientific Meeting of Hong Kong Pharmacology Society, June 12-15, 2009, Hong Kong. 2009.

Researcher : Qu C

List of Research Outputs

Researcher : Tang HC

List of Research Outputs

Tang H.C. and Vanhoutte P.M.G.R., Gap junction inhibitors reduce endothelium-dependent contractions in the aorta of sponteanously hypertensive rats, The Journal of Pharmacology and Experimental Therapeutics. 2008, 2008; 327(1): 1-6.

Tang H.C. and Vanhoutte P.M.G.R., Prostanoids and reactive oxygen species: Team players in endothelium-dependent contractions, Pharmacology & Therapeutics. 2009, 2009, 122: 140-149.

Vanhoutte P.M.G.R., Tang H.C., Feletou M. and Shimokawa H., Endothelial dysfunction and vascular disease, Acta Physiol. 2009, 2009;196: 193-222.

Vanhoutte P.M.G.R. and Tang H.C., Endothelium-dependent contractions: when a good guy turns bad!, The Journal of Physiology. 2008, 2008, 586(22): 5295-5304.

Researcher : Vanhoutte PMGR

List of Research Outputs

Al-Mashhadj R...H..., Skott O., Vanhoutte P.M.G.R. and Hansen P...B..., Adenosine dilates the cortical efferent arteriole of the mouse by activating A₂adenosine receptors, Kidney International. 2009, 2009;75: 793-795.

Chan C.K.Y., Man R.Y.K. and Vanhoutte P.M.G.R., Contractile response to hypoxia in the porcine coronary artery, 13th Research Postgraduate Symposium, December 10-11, 2008.

Chan C.K.Y., Mak J.C.W., Man R.Y.K. and Vanhoutte P.M.G.R., Contractile response to hypoxia in the porcine coronary artery, Twelfth Annual Scientific Meeting of Institute of Cardiovascular Science and Medince, December 13-14, 2008, Hong Kong. 2008.

Chan C.K.Y., Vanhoutte P.M.G.R., Man R.Y.K. and Mak J.C.W., Nitric oxide synthase and soluble guanylyl cyclase activation are required for hypoxic endothelium-dependent contractions of the porcine coronary artery, 10th International Symposium on Mechanisms of Vasodilatation, Matsushima, Miyagi, Japan, June 1-3, 2009.

Chan C.K.Y., Mak J.C.W., Man R.Y.K. and Vanhoutte P.M.G.R., Nitric oxide synthase and soluble guanylyl cyclase activation are required for hypoxic endothelium-dependent contractions of the porcine coronary artery, Twelfth Scientific Meeting of Hong Kong Pharmacology Society, June 12-15, 2009, Hong Kong. 2009.

Chan C.K.Y., Mak J.C.W., Man R.Y.K. and Vanhoutte P.M.G.R., Rho kinase inhibitors prevent endothelium-dependent contractions in the rat aorta, Fourth International Symposium on Healthy Aging of Research Centre of Heart, Brain, Hormone & Healthy Aging, March 7-8, 2009, Hong Kong. 2009.

Chan C.K.Y., Vanhoutte P.M.G.R., Man R.Y.K. and Mak J.C.W., Rho kniase inhibitors prevent endothelium-dependent contractions in the rats aorta, 10th International Symposium on Mechanisms of Vasodilatation, Matsushima, Miyagi, Japan, June 1-3, 2009.

Chan K.Y.C., Mak J.C.W., Man R.Y.K. and Vanhoutte P.M.G.R., Rho kinase inhibitors prevent endothelium-dependent contractions in the rat aorta, J Pharmacol Exp Ther. 2009, 329: 820-826.

Cheng K.Y., Iglesias M.A., Lam K.S.L., Wang Y., Sweeney G., Zhu W., Vanhoutte P.M.G.R., Kraegen E.W. and Xu A., APPL1 potentiates hepatic insulin sensitivity on inhibition of glucose production and alleviates diabetes via Akt activation in mice, Cell Metab. 2009, 9: 417-27.

Cheng K.Y., Iglesias M.A., Wang Y., Sweeney G., Zhu W., Vanhoutte P.M.G.R., Kraegen E.W. and Xu A., Appl1 Potentiates Insulin-mediated Inhibition Of Hepatic Glucose Production And Alleviates Diabetes Via Akt Activation In Mice, In: Cheng KK, Iglesias MA, Lam KS, Wang Y, Sweeney G, Zhu W, Vanhoutte PM, Kraegen EW, Xu A, Cell Metabolism. USA, 2009, 9: 417-427.

Feletou M., Verbeuren T...J... and Vanhoutte P.M.G.R., Endothelium-dependent contractions in SHR: a tale of prostanoid TP and IP receptors, British Journal of Pharmacology . 2008, 2009;156: 563-574.

Ho Y.W., Leung G.P.H., Man R.Y.K., Vanhoutte P.M.G.R. and Ng J.K.F., Distributions of alpha 2 adrenoceptor subtypes in porcine coronary vasculature. San Diego, 5-9 Apr , Experimental Biology . 2008.

Ho Y.W., Leung G.P.H., Man R.Y.K., Vanhoutte P.M.G.R. and Ng J.K.F., Distributions of alpha 2 adrenoceptor subtypes in porcine coronary vasculature, FASEB Journal. 2008, 22: 914.10.

Ho Y.W., Li W.S.R., Vanhoutte P.M.G.R., Man R.Y.K., Leung S.W.S. and Leung G.P.H., Possible role of organic cation transport-3 in serotonin uptake in human brain vascular smooth muscle cells, 10th International Symposium on Mechanisms of Vasodilatation 2009.

Ho Y.W., Li W.S.R., Vanhoutte P.M.G.R., Man R.Y.K., Leung S.W.S. and Leung G.P.H., Possible role of organic cation transpporter-3 in serotonin uptake in human brain vascular smooth muscle cells, Journal of vascular research . 2009, 46 supp 1: 202.

Keung W.Y.W., Chan M.L.Y., Vanhoutte P.M.G.R., Leung S.W.S. and Man R.Y.K., The effect of 17b-estradiol on adenylyl cyclase and protein kinase G in the regulation of vascular tone, 10th International Symposium on Mechanisms of Vasodilatation 2009 . 2009.

Kong B.W.C., Man R.Y.K., Vanhoutte P.M.G.R. and Leung S.W.S., Hypertension and EDHF-mediated responses in mesenteric arteries of the rats, 10th International Symposium on Mechanisms of Vasodilatation, Matsushima, Miyagi, Japan, June 1-3, 2009.

Kong W.C.B., Man R.Y.K., Vanhoutte P.M.G.R. and Leung S.W.S., Aging and hypertension attenuate relaxations due to endothelium-derived hyperpolarizing factor in the rat superior mesenteric artery , 10th International Symposium on Mechanisms of Vasodilatation 2009 . 2009.

Kong W.C.B., Leung S.W.S., Man R.Y.K. and Vanhoutte P.M.G.R., The effect of aging and hypertension on endothelial-derived hyperpolarizing factor (EDHF)-mediated responses in spontaneously hypertensive rats, Journal of the Hong Kong College of Cardiology, 2008/ The 12th Annual Scientific Meeting, Institute of Cardiovascular Science and Medicine, The University of Hong Kong . 2008, 16: 63.

Law K.M., Liu L., Xu A., Lam K.S.L., Vanhoutte P.M.G.R., Che C.M., Leung T.Y. and Wang Y., Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins., Proteomics. 2009, 9: 2444-56.

Lee M.Y.K., Vanhoutte P.M.G.R. and Xu A., Adipocyte-fatty acid binding protein (A-FABP) is present in the endothelium of male apolipoprotein E-knockout mice, Twelfth Annual Scientific Meeting of Institute of Cardiovascular Science and Medince, December 13-14, 2008, Hong Kong. 2008.

Lee M.Y.K., Tse H.F., Wang Y. and Vanhoutte P.M.G.R., Gender differences in the genomic changes in cultures derived from procine regenerated coronary endothelial cells fed with a high cholesterol diet, Fourth International Symposium on Healthy Aging of Research Centre of Heart, Brain, Hormone & Healthy Aging, March 7-8, 2009, Hong Kong. 2009.

Lee M.Y.K., Vanhoutte P.M.G.R. and Xu A., Pharmacological inhibition of adipocyte-fatty acid binding protein (A-FABP) improves endothelial function in male apolipoprotein e-knockout mice, International Symposium on Mechanisms of Vasodilatation. Matsushima, Miyagi, Japan. 01-03 Jun 2009.

Lee M.Y.K., Sørensen G.R.I.T.H. .L., Holmskov U.F.F.E. and Vanhoutte P.M.G.R., The presence and activity of SP-D in porcine coronary endothelial cells depend on Akt/PI3K, Erk and nitric oxide and decrease after multiple passaging, Molecular Immunology. 2008, 46: 1050.

Leung I.C.Y., Vanhoutte P.M.G.R., Man R.Y.K. and Leung G.P.H., Tissue-type plasminogen activator: A possible candidate of endothelium-derved hyperpolarization factor?, Twelfth Annual Scientific Meeting of Institute of Cardiovascular Science and Medince, December 13-14, 2008, Hong Kong. 2008.

Leung I.C.Y., Vanhoutte P.M.G.R., Man R.Y.K. and Leung G.P.H., Tissue-type plasminogen activator: a possible candidate of endothelium-derived hyperpolarization factor?, 13th Research Postgraduate Symposium, December 10-11, 2008.

Li W.S.R., Man R.Y.K., Vanhoutte P.M.G.R. and Leung G.P.H., Stimulation of ecto-5'nucleotidase in human umbilical vein endothelial cells by lipopolysaccharide, American Journal of Physiology Heart and Circulation Physiology. 2008.

Li Z., Koo M.W.L., Wang Y. and Vanhoutte P.M.G.R., Epigallocatechin gallate causes endothelium dependent contractions in the rat aorta, 10th International Symposium on Mechanisms of Vasodilatation, Matsushima, Miyagi, Japan, June 1-3, 2009.

Li Z., Koo M.W.L., Wang Y. and Vanhoutte P.M.G.R., Epigllocatechin gallate induces contractions of the rats aorta due to production of reactive oxygen species, activation of cyclooxygenase and stimulation of thromboxane-prostanoid receptor, Twelfth Scientific Meeting of Hong Kong Pharmacology Society, June 12-15, 2009 Hong Kong. 2009.

Liang C., Leung S.W.S., Ng J.K.F., Feletou M., Man R.Y.K. and Vanhoutte P.M.G.R., Endothelium-derived NO inhibits the relaxation to C-type natriuretic peptide (CNP) in porcine coronary arteries, Twelfth Scientific Meeting of Hong Kong Pharmacology Society, June 12-15, 2009, Hong Kong. 2009.

Liang C., Leung S.W.S., Ng J.K.F., Man R.Y.K., Feletou M. and Vanhoutte P.M.G.R., Endothelium-derived nitric oxide inhibits CNP-induced relaxation in the isolated porcine coronary artery, 10th International Symposium on Mechanisms of Vasodilatation 2009 . 2009.

Liang C., Leung S.W.S., Ng J.K.F., Man R.Y.K. and Vanhoutte P.M.G.R., Inhibition of the relaxation to CNP by endothelium-derived nitric oxide in the porcine coronary artery, Journal of the Hong Kong College of Cardiology, 2008/ The 12th Annual Scientific Meeting, Institute of Cardiovascular Science and Medicine, The University of Hong Kong . 2008, 16: 64.

Liang C., Leung S.W.S., Ng J.K.F., Man R.Y.K., Feletou M. and Vanhoutte P.M.G.R., The inhibition of endothelium-derived nitric oxide on CNP-induced relaxation in the isolated porcine coronary artery, Fourth International Symposium on Healthy Aging of Research Centre of Heart, Brain, Hormone & Healthy Aging, March 7-8, 2009, Hong Kong. 2009.

Liang C., Leung S.W.S., Ng J.K.F., Man R.Y.K., Feletou M. and Vanhoutte P.M.G.R., The inhibition of endothelium-derived nitric oxide on CNP-induced relaxation in the isolated porcine coronary artery, Fourth International Symposium on Healthy Aging: Emerging Therapies for an Aging Population. 2009.

Liang S.C., Leung S.W.S., Ng J.K.F., Man R.Y.K., Feletou M. and Vanhoutte P.M.G.R., Endothelium-derived nitric oxide inhibites CNP-induced relaxation in the isolated porcine coronary artery, Mechanism of Vasodilatation MOVD 2009, Matsushima, 1-3 June. 2009.

Liu T.C., Xu A., Man R.Y.K., Vanhoutte P.M.G.R., Mak T.A.K. and Wang Y., Absence of lipocalin-2 prevents endothelium-dependent contractions induced by aging and high fat diet feeding in mice, 10th International Symposium on Mechanisms of Vasodilatation. 2009.

Liu T.C., Xu A., Man R.Y.K., Vanhoutte P.M.G.R., Mak T...W..., Law K.M. and Wang Y., Lipocalin-2 deficiency attenuates endothelial dysfunction associated with aging and obesity, Fourth International Symposium on Healthy Aging of Research Centre of Heart, Brain, Hormone & Healthy Aging, March 7-8, 2009, Hong Kong. 2009.

Man R.Y.K., Keung W.W.Y., Chan M.L.Y. and Vanhoutte P.M.G.R., The effect of the female hormone, 17b-Estradiol, on adenylyl cyclase and protein kinase G in the regulation of vascular function, 10th International Symposium on Mechanisms of Vasodilatation, Matsushima, Miyagi, Japan, June 1-3, 2009.

Michel F...S..., Man G.S.K., Man R.Y.K. and Vanhoutte P.M.G.R., Hypertension and the absence of EDHF-mediated responses favor endothelium-dependent contractions in renal arteries of the rat, British Journal of Pharmacology. 2008, 2008, 13: 4198-4217.

Ng J.K.F., Leung S.W.S., Man R.Y.K. and Vanhoutte P.M.G.R., C-type natriuretic peptide (CNP) release does not contribute to endothelium-derived hyperpolarizing factor (EDHF) mediated relaxation inporcine coronary artery, FASEB Journal. 2008, 22: 914.3.

Ng J.K.F., Leung S.W.S., Man R.Y.K. and Vanhoutte P.M.G.R., C-type natriuretic petide (CNP) release does not contribute to endothelium -derived hyperpolarizing factor (EDHF) medicated relaxation in porcine coronary artery. San Diego, 5-9 Apr , Experimental Biology 2008.

Ng J.K.F., Chan M.L.Y., Man R.Y.K. and Vanhoutte P.M.G.R., Dexmedetomidine relaxes isolated porcine coronary arteries by activating endothelial  2A, 2B and 2C adrenoceptors, Mechanism of Vasodilatation MOVD 2009.

Ng J.K.F., Chan M.L.Y., Man R.Y.K. and Vanhoutte P.M.G.R., Dexmedetomidine relaxes isolated porcine coronary arteries by activating enothelial a 2A, 2B and 2C adrenoceptors, Mechanism of Vasodilatation MOVD 2009, Matsushima. 2009.

Ng J.K.F., Leung G.P.H., Ho Y.W., Man R.Y.K. and Vanhoutte P.M.G.R., Dexmedetomidine relaxes isolated porcine coronary artery via endothelial 2A receptors, Annual Meeting of the American Society of Anaesthesioogists, Orlando, 18-22 Oct. 2008.

Ng J.K.F., Leung S.W.S., Man R.Y.K. and Vanhoutte P.M.G.R., EDHF-mediated relaxations in pig coronary arteries do not involve Gi/o proteins, Acta Pharmacol Sin. 2008, 29: 1419-1424.

Ng J.K.F., Leung S.W.S., Man R.Y.K. and Vanhoutte P.M.G.R., Endothelium-derived hyperpolarizing factor mediated relaxations in porcine coronary arteries do not involve Gi/o proteins, Acta Pharmacologica Sinica. 2008, 29: 1419-1424.

Ng W.W.H., Keung W.W.Y., Xu Y., Ng J.K.F., Leung G.P.H., Vanhoutte P.M.G.R., Choy P.C. and Man R.Y.K., Genistein otentiates protein kinase A activity in porcine coronary artery, Mol Cell Biochem. 2008, 311: 37-44.

Qu C., Leung S.W.S., Vanhoutte P.M.G.R. and Man R.Y.K., Effect of PPAR agonists on relaxations and contractions of the SHR aorta, 10th International Symposium on Mechanisms of Vasodilatation 2009.

Qu C., Leung S.W.S., Vanhoutte P.M.G.R. and Man R.Y.K., Effect of PPAR agonists on relaxations and contractions of the SHR aorta, Twelfth Scientific Meeting of Hong Kong Pharmacology Society, June 12-15, 2009, Hong Kong. 2009.

Schini-Kerth V... .B... and Vanhoutte P.M.G.R., In: Nitric Oxide, Cardiovascular Hormone Systems. 2008, 395-406.

Tang H.C. and Vanhoutte P.M.G.R., Gap junction inhibitors reduce endothelium-dependent contractions in the aorta of sponteanously hypertensive rats, The Journal of Pharmacology and Experimental Therapeutics. 2008, 2008; 327(1): 1-6.

Tang H.C. and Vanhoutte P.M.G.R., Prostanoids and reactive oxygen species: Team players in endothelium-dependent contractions, Pharmacology & Therapeutics. 2009, 2009, 122: 140-149.

Vanhoutte P.M.G.R., COX-1 and Vascular Disease, Translational Medicine . 2009, 2009, 86(2): 212-215.

Vanhoutte P.M.G.R., Endothelial Dysfunction - The first step toward coronary arteriosclerosis, Circulation Journal. 2009, 2009, 73(4): 595-601.

Vanhoutte P.M.G.R., Endothelial Dysfunction - The first step towards coronary disease, Asia Pacific Cardiology. 2009, 2009: 1-5.

Vanhoutte P.M.G.R., Tang H.C., Feletou M. and Shimokawa H., Endothelial dysfunction and vascular disease, Acta Physiol. 2009, 2009;196: 193-222.

Vanhoutte P.M.G.R., Endothelial regeneration: From phenotypic alterations to genomic changes, Frontiers in Biomedical Research HKU 2008.

Vanhoutte P.M.G.R. and Tang H.C., Endothelium-dependent contractions: when a good guy turns bad!, The Journal of Physiology. 2008, 2008, 586(22): 5295-5304.

Vanhoutte P.M.G.R., How we learned to say NO, Arteriosclerosis, Thrombosis and Vascular Biology. 2009, 2009:29: 1156-1160.

Walter A., Etienne-Selloum N., Brasse D., Schleiffer R., Bekaert V., Vanhoutte P.M.G.R., Beretz A. and Schini-Kerth V.B., Red Wine Polyphenois Prevent Acceleration of Neovascularization by Angiotensin II in the Ischemic Rat Hindlimb, The Journal of Pharmacology and Experimental Therapeutics. 2009, 329:2: 699-707.

Wang Y., Huang Y., Lam K.S.L., Li Y., Wong W.T., Ye H.Y., Lau C.W., Vanhoutte P.M.G.R. and Xu A., Berberine prevents hyperglycemia-induced endothelial injury and enhances vasodilatation through eNOS and AMP-activated protein kinase. , Cardiovascular Research. Oxford, 2009, 82: 484-92.

Wang Y., Zu Y., Liu L., Lam K.S.L., Lee M.Y.K., Vanhoutte P.M.G.R. and Xu A., SIRT1 promotes cell proliferation and prevents cellular senescence through targeting LKB1 in primary cultures of porcine aortic endothelial cells, 10th International Symposium on Mechanisms of Vasodilatation. 2009.

Wong E.S.W., Man R.Y.K., Vanhoutte P.M.G.R. and Ng J.K.F., Differential effects of alpha-adrenoceptor agonists on relaxation in the mesenteric artery and aorta of the rat, Mechanism of Vasodilatation MOVD 2009, Matsushima, 1-3 June. 2009.

Wong E.S.W., Ng J.K.F., Man R.Y.K. and Vanhoutte P.M.G.R., Effects of dexmedetomidine in isolated arteries of pig and rat, 5th International EDFH Symposium, Tampere, 24-27 June. 2008.

Wong E.S.W., Man R.Y.K., Vanhoutte P.M.G.R. and Ng J.K.F., Effects of dexmedetomidine in the mesenteric artery and the aorta of the rat, 13th Research Postgraduate Symposium, December 10-11, 2008.

Wong E.S.W., Man R.Y.K., Vanhoutte P.M.G.R. and Ng J.K.F., Vascular effects of dexmedetomidine in isolated mesenteric artery and aorta of endotoxemic rat, 12th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, The University of Hong Kong, 13-14 Dec. 2008.

Wong S...L..., Leung F...P..., Lau C...W..., Au C...L., Yung L...M..., Yao X...Q..., Chen Z...Y..., Vanhoutte P.M.G.R., Gollasch M. and Huang Y., Cyclooxygenase-2-Derived prostaglandin F_2amediates endothelium-dependent contractions in the aortae of hamsters with increased impact during aging, Circulation Research. 2008, 2009;104: 228-235.

Wong S.K., Man R.Y.K. and Vanhoutte P.M.G.R., Calcium-independent phospholipase A2 involves in endothelium-dependent contractions in the aorta of the spontaneously hupertensive rats, Twelfth Annual Scientific Meeting of Institute of Cardiovascular Science and Medince, December 13-14, 2008, Hong Kong. 2008.

Wong S.K., Man R.Y.K. and Vanhoutte P.M.G.R., Calcium-independent phospholipase A2 is involved in endothelium-dependent contractions of the aorta of the spontaneously hypertensive rats, 10th International Symposium on Mechanisms of Vasodilatation, Matsushima, Miyagi, Japan, June 1-3, 2009.

Wong S.K., Man R.Y.K. and Vanhoutte P.M.G.R., Vitamin D derivatives acutely reduce endothelium-dependent contractions in the aorta of the spontaneously hypertensive rats, The 3rd Scientific Meeting of The Asian Society for Vascular Biology, Singapore, August 4-5, 2008. 29.

Wong S.W.E., Man R.Y.K., Vanhoutte P.M.G.R. and Ng J.K.F., Differential effects of alpha-adrenoceptor agonists on relaxation in the mesenteric artery and aorta of the rat., Mechanism of Vasodilatation MOVD 2009.

Xia Z., Liu H., Wang F., Luo T., Xia Z.Y., Irwin M.G. and Vanhoutte P.M.G.R., L-arginine enhances nitrative stress and exacerbates TNF-alpha toxicity in endothelial cells, FASEB J. 2009, 23: 963.2.

Xu A., Wang H., Hoo R.L.C., Sweeney G., Vanhoutte P.M.G.R., Wang Y., Wu D., Chu W., Qin G. and Lam K.S.L., Selective elevation of adiponectin production by the natural compounds derived from a medicinal herb alleviates insulin resistance and glucose intolerance in mice, Endocrinology. 2009, 150(2): 625-33.

Zu Y., Liu L., Xu A., Lee M.Y.K., Lam K.S.L., Vanhoutte P.M.G.R. and Wang Y., SIRT1 promotes cell proliferation and prevents cellularr senescence in primary porcine endothelial cells, Fourth International Symposium on Healthy Aging of Research Centre of Heart, Brain, Hormone & Healthy Aging, March 7-8, 2009, Hong Kong. 2009.

Researcher : Wang Y

List of Research Outputs

Cheng K.Y., Iglesias M.A., Lam K.S.L., Wang Y., Sweeney G., Zhu W., Vanhoutte P.M.G.R., Kraegen E.W. and Xu A., APPL1 potentiates hepatic insulin sensitivity on inhibition of glucose production and alleviates diabetes via Akt activation in mice, Cell Metab. 2009, 9: 417-27.

Cheng K.Y., Lglesias M.A., Lam K.S.L., Wang Y., Sweeney G., Zhu W., Hoo R.L.C., Kraegen E.W. and Xu A., Appl1 As A Novel Regulator Of Hepatic Insulin Sensitivity And Glucose Homeostasis: Molecular Mechanism And Physiological Relevance, In: Cheng KK, Iglesias MA, Lam KS, Wang Y, Sweeney G, Zhu W, Hoo CL, Kraegen EW, Xu A, 14th Medical Research Conference. Hong Kong, University of Hong Kong, 2009.

Cheng K.Y., Iglesias M.A., Wang Y., Sweeney G., Zhu W., Vanhoutte P.M.G.R., Kraegen E.W. and Xu A., Appl1 Potentiates Insulin-mediated Inhibition Of Hepatic Glucose Production And Alleviates Diabetes Via Akt Activation In Mice, In: Cheng KK, Iglesias MA, Lam KS, Wang Y, Sweeney G, Zhu W, Vanhoutte PM, Kraegen EW, Xu A, Cell Metabolism. USA, 2009, 9: 417-427.

Cheung M.M.S., Chan K.Y., Leung T.Y., Wang Y. and Leung K.M.Y., Differential expression of two distinctive metallothionein isoforms in the rock shell Thais clavigera in relation to different chemical stressors, The 5th SETAC World Congress, 3-7 August 2008, Sydney Convention and Exhibition Centre, Sydney, Australia. 2008.

Hui X., Zhu W., Wang Y., Lam K.S.L., Zhang J., Wu D., Kraegen E., Li Y. and Xu A., Major Urinary Protein -1 Increases Energy Expenditure and Improves Glucose Intolerance Through Enhancing Mitochondria Function in Skeletal Muscle of Diabetic mice., Journal of Biological Chemistry. 2009, 284: 14050-14057.

Lam J.B.B., Chow H.M., Xu A., Lam K.S.L., Liu J., Moon R.T., Shepherd P.R., Cooper G.J. and Wang Y., Adiponectin haploinsufficiency promotes mammary tumor development in MMTV-PyVT mice by modulation of phosphatase and tensin homolog activities., PLoS ONE. 2009, 4: e4968.

Lam J.B.B. and Wang Y., Adiponectin, In: Manfred Schwab, Encyclopedia of Cancer. 2009, 2nd Edition.

Law K.M., Liu L., Xu A., Lam K.S.L., Vanhoutte P.M.G.R., Che C.M., Leung T.Y. and Wang Y., Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins., Proteomics. 2009, 9: 2444-56.

Law K.M., Xu A., Lam K.S.L., Liu T.C., Berger T., Mak T...W..., Zhang M...X...M... and Wang Y., Mice lacking lipicalin-2 show increased insulin sensitivity and are resistant to high fat diet- and genetic obesity-induced insulin resistance and diabetes, 13th Research Postgraduate Symposium, December 10-11, 2008.

Law K.M., Xu A., Lam K.S.L., Berger T.H.O.R.S.T.E.N., Mak T.A.K., Liu T.C., Sweeney G.A.R.Y., Zhou M. and Wang Y., Protection from obesity-induced insulin resistance in mice lacking lipocalin-2 , Fourth International Symposium on Healthy Aging. 2009.

Lee M.Y.K., Tse H.F., Wang Y. and Vanhoutte P.M.G.R., Gender differences in the genomic changes in cultures derived from procine regenerated coronary endothelial cells fed with a high cholesterol diet, Fourth International Symposium on Healthy Aging of Research Centre of Heart, Brain, Hormone & Healthy Aging, March 7-8, 2009, Hong Kong. 2009.

Leung T.Y., Wang Y., Mak S.T., Park T.J., Ng W.C. and Leung K.M.Y., Protemic profiling of metallothionein isoforms in the green-lipped mussel Perna viridis exposed to metal and non-metal stressors, The 5th SETAC World Congress, 3-7 August 2008, Sydney Convention and Exhibition Centre, Sydney, Australia. 2008.

Leung T.Y., Wang Y., Park T.J. and Leung K.M.Y., Proteomic profiling of metallothionein isoforms in the green-lipped mussel Perna viridis exposed to metal and non-metal stressors, The 15th International Symposium on Pollutant Responses in Marine Organisms (PRIMO), 17-20 May 2009, Bordeaux, France. 2009.

Li Z., Koo M.W.L., Wang Y. and Vanhoutte P.M.G.R., Epigallocatechin gallate causes endothelium dependent contractions in the rat aorta, 10th International Symposium on Mechanisms of Vasodilatation, Matsushima, Miyagi, Japan, June 1-3, 2009.

Li Z., Koo M.W.L., Wang Y. and Vanhoutte P.M.G.R., Epigllocatechin gallate induces contractions of the rats aorta due to production of reactive oxygen species, activation of cyclooxygenase and stimulation of thromboxane-prostanoid receptor, Twelfth Scientific Meeting of Hong Kong Pharmacology Society, June 12-15, 2009 Hong Kong. 2009.

Liu J., Lam J.B.B., Chow H.M., Xu A., Lam K.S.L., Randall T. and Wang Y., Adiponectin stimulates Wnt inhibitory factor-1 expression through epigenetic regulations involving the transcription factor specificity protein 1, Carcinogenesis . 2008, 31: 1889-91.

Liu T.C., Xu A., Man R.Y.K., Vanhoutte P.M.G.R., Mak T.A.K. and Wang Y., Absence of lipocalin-2 prevents endothelium-dependent contractions induced by aging and high fat diet feeding in mice, 10th International Symposium on Mechanisms of Vasodilatation. 2009.

Liu T.C., Xu A., Man R.Y.K., Vanhoutte P.M.G.R., Mak T...W..., Law K.M. and Wang Y., Lipocalin-2 deficiency attenuates endothelial dysfunction associated with aging and obesity, Fourth International Symposium on Healthy Aging of Research Centre of Heart, Brain, Hormone & Healthy Aging, March 7-8, 2009, Hong Kong. 2009.

Wang Y., Lam K.S.L. and Xu A., Protective roles of adiponectin in obesity-related fatty liver diseases: Mechanisms and Therapeutic Interventions, the International Society for Endocrinology meeting. 2008.

Wang Y., Zhou M., Lam K.S.L. and Xu A., Protective roles of adiponectin in obesity-related fatty liver diseases: mechanisms and therapeutic implications., Arq Bras Endocrinol Metabol. . 2009, 53: 201-12.

Wang Y., Zu Y., Liu L., Lam K.S.L., Lee M.Y.K., Vanhoutte P.M.G.R. and Xu A., SIRT1 promotes cell proliferation and prevents cellular senescence through targeting LKB1 in primary cultures of porcine aortic endothelial cells, 10th International Symposium on Mechanisms of Vasodilatation. 2009.

Wang Y., Yao M., Lam K.S.L., Zhang J., Wu D.H. and Xu A., Structural Mechanisms underlying the Inhibitory Effects of Angiopoietin-like Protein 4 on Lipoprotein Lipase Activities, 4th Scientific Meeting of Asia-Pacific Diabetes and Obesity Study Group. 2008.

Williams G.A., Wang Y., Callon K.E., Watson M., Lin J.M., Lam J.B., Naot D., Reid I.R. and Cornish J., In Vitro and In Vivo Effects of Adiponectin on Bone., Endocrinology. 2009.

Yau J.M.H., Wang Y., Lam K.S.L., Zhang J., Wu D. and Xu A., A highly conserved motif within the nh2-terminal coiled-coil domain of angiopoietin-like protein 4 confers its inhibitory effects on lipoprotein lipase through disrupting the enzyme dimerization, J Biol Chem. 2009, 284(18): 11942-52.

Yeung C.Y., Wang Y., Xu A., Cheung S.C.W., Fong D.Y.T., Fong H.Y., Chau M.T., Sham P.C. and Lam K.S.L., Epidermal fatty-acid-binding protein: a new circulating biomarker associated with cardio-metabolic risk factors and carotid atherosclerosis, Euro Heart J . 2008, 29: 2156-63.

Yeung C.Y., Lam K.S.L., Wang Y., Tso A.W.K. and Xu A., Serum zinc-alpha2-glycoprotein correlates with adiposity, triglycerides and the key components of the metabolic syndrome in Chinese subjects., J Clin Endocrinol Metab. . 07/2009, 2009, 94: 2531-2536.

Zhou M., Xu A., Tam P.K.H., Lam K.S.L., Chan L., Hoo R.L.C., Liu J., Chow H.M. and Wang Y., Mitochondrial dysfunction contributes to the increased vulnerabilities of adiponectin knockout mice to liver injury., Hepatology. 2008, 48 (4): 1087-96.

Zhou M., Xu A., Tam P.K.H., Lam K.S.L., Chan L., Liu J., Chow H.M. and Wang Y., Mitochondrial dysfunction contributes to the increased vulnerabilities of adiponectin knockout mice to liver injury, Fourth International Symposium on Healthy Aging: "Emerging Therapies for an Aging Population". 2009.

Zu Y., Liu L., Xu A., Lee M.Y.K., Lam K.S.L., Vanhoutte P.M.G.R. and Wang Y., SIRT1 promotes cell proliferation and prevents cellularr senescence in primary porcine endothelial cells, Fourth International Symposium on Healthy Aging of Research Centre of Heart, Brain, Hormone & Healthy Aging, March 7-8, 2009, Hong Kong. 2009.

Researcher : Wong ESW

List of Research Outputs

Wong E.S.W., Man R.Y.K., Vanhoutte P.M.G.R. and Ng J.K.F., Differential effects of alpha-adrenoceptor agonists on relaxation in the mesenteric artery and aorta of the rat, Mechanism of Vasodilatation MOVD 2009, Matsushima, 1-3 June. 2009.

Wong E.S.W., Ng J.K.F., Man R.Y.K. and Vanhoutte P.M.G.R., Effects of dexmedetomidine in isolated arteries of pig and rat, 5th International EDFH Symposium, Tampere, 24-27 June. 2008.

Wong E.S.W., Man R.Y.K., Vanhoutte P.M.G.R. and Ng J.K.F., Effects of dexmedetomidine in the mesenteric artery and the aorta of the rat, 13th Research Postgraduate Symposium, December 10-11, 2008.

Wong E.S.W., Man R.Y.K., Vanhoutte P.M.G.R. and Ng J.K.F., Vascular effects of dexmedetomidine in isolated mesenteric artery and aorta of endotoxemic rat, 12th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, The University of Hong Kong, 13-14 Dec. 2008.

Researcher : Wong SK

List of Research Outputs

Wong S.K., Man R.Y.K. and Vanhoutte P.M.G.R., Calcium-independent phospholipase A2 involves in endothelium-dependent contractions in the aorta of the spontaneously hupertensive rats, Twelfth Annual Scientific Meeting of Institute of Cardiovascular Science and Medince, December 13-14, 2008, Hong Kong. 2008.

Wong S.K., Man R.Y.K. and Vanhoutte P.M.G.R., Calcium-independent phospholipase A2 is involved in endothelium-dependent contractions of the aorta of the spontaneously hypertensive rats, 10th International Symposium on Mechanisms of Vasodilatation, Matsushima, Miyagi, Japan, June 1-3, 2009.

Wong S.K., Man R.Y.K. and Vanhoutte P.M.G.R., Vitamin D derivatives acutely reduce endothelium-dependent contractions in the aorta of the spontaneously hypertensive rats, The 3rd Scientific Meeting of The Asian Society for Vascular Biology, Singapore, August 4-5, 2008. 29.

Researcher : Wong SK

List of Research Outputs

Researcher : Wong SWE

List of Research Outputs

Wong S.W.E., Man R.Y.K., Vanhoutte P.M.G.R. and Ng J.K.F., Differential effects of alpha-adrenoceptor agonists on relaxation in the mesenteric artery and aorta of the rat., Mechanism of Vasodilatation MOVD 2009.

Researcher : Wu KK

List of Research Outputs

Li P., Wu K.K., Wong H.P.S., Zhang S.T., Yu L. and Cho C.H., Chloroform extract of cigarette smoke induces proliferation of human esophageal squamous-cell carcinoma cells: modulation by beta-adrenoceptors, Drug and Chemical Toxicology. 2009, 32: 175-181.

Researcher : Xia Z

List of Research Outputs

Xia Z. and Xia Z., Peer Reviewer, Biochemical Pharmacology . 2009.

Xia Z. and Xia Z., Peer reviewer, Anesthesiology. 2008.

Xia Z. and Xia Z., Peer reviewer, Biochemical Pharmacology . 2009.

Xia Z., Peer reviewer, Journal of Zhejiang University-SCIENCE B . 2009.

Researcher : Xu A

List of Research Outputs

Cheng K.Y., Lglesias M.A., Lam K.S.L., Wang Y., Sweeney G., Zhu W., Hoo R.L.C., Kraegen E.W. and Xu A., Appl1 As A Novel Regulator Of Hepatic Insulin Sensitivity And Glucose Homeostasis: Molecular Mechanism And Physiological Relevance, In: Cheng KK, Iglesias MA, Lam KS, Wang Y, Sweeney G, Zhu W, Hoo CL, Kraegen EW, Xu A, 14th Medical Research Conference. Hong Kong, University of Hong Kong, 2009.

Lam J.B.B., Chow H.M., Xu A., Lam K.S.L., Liu J., Moon R.T., Shepherd P.R., Cooper G.J. and Wang Y., Adiponectin haploinsufficiency promotes mammary tumor development in MMTV-PyVT mice by modulation of phosphatase and tensin homolog activities., PLoS ONE. 2009, 4: e4968.

Law K.M., Xu A., Lam K.S.L., Liu T.C., Berger T., Mak T...W..., Zhang M...X...M... and Wang Y., Mice lacking lipicalin-2 show increased insulin sensitivity and are resistant to high fat diet- and genetic obesity-induced insulin resistance and diabetes, 13th Research Postgraduate Symposium, December 10-11, 2008.

Law K.M., Xu A., Lam K.S.L., Berger T.H.O.R.S.T.E.N., Mak T.A.K., Liu T.C., Sweeney G.A.R.Y., Zhou M. and Wang Y., Protection from obesity-induced insulin resistance in mice lacking lipocalin-2 , Fourth International Symposium on Healthy Aging. 2009.

Lee M.Y.K., Vanhoutte P.M.G.R. and Xu A., Adipocyte-fatty acid binding protein (A-FABP) is present in the endothelium of male apolipoprotein E-knockout mice, Twelfth Annual Scientific Meeting of Institute of Cardiovascular Science and Medince, December 13-14, 2008, Hong Kong. 2008.

Lee M.Y.K., Vanhoutte P.M.G.R. and Xu A., Pharmacological inhibition of adipocyte-fatty acid binding protein (A-FABP) improves endothelial function in male apolipoprotein e-knockout mice, International Symposium on Mechanisms of Vasodilatation. Matsushima, Miyagi, Japan. 01-03 Jun 2009.

Liu T.C., Xu A., Man R.Y.K., Vanhoutte P.M.G.R., Mak T.A.K. and Wang Y., Absence of lipocalin-2 prevents endothelium-dependent contractions induced by aging and high fat diet feeding in mice, 10th International Symposium on Mechanisms of Vasodilatation. 2009.

Liu T.C., Xu A., Man R.Y.K., Vanhoutte P.M.G.R., Mak T...W..., Law K.M. and Wang Y., Lipocalin-2 deficiency attenuates endothelial dysfunction associated with aging and obesity, Fourth International Symposium on Healthy Aging of Research Centre of Heart, Brain, Hormone & Healthy Aging, March 7-8, 2009, Hong Kong. 2009.

Wang Y., Lam K.S.L. and Xu A., Protective roles of adiponectin in obesity-related fatty liver diseases: Mechanisms and Therapeutic Interventions, the International Society for Endocrinology meeting. 2008.

Wang Y., Zhou M., Lam K.S.L. and Xu A., Protective roles of adiponectin in obesity-related fatty liver diseases: mechanisms and therapeutic implications., Arq Bras Endocrinol Metabol. . 2009, 53: 201-12.

Zhou Y., Wang D., Zhu Q., Gao X., Yang S., Xu A. and Wu D., Inhibitory effects of A-769662, a novel activator of AMP-activated protein kinase, on 3T3-L1 adipogenesis., Biol Pharm Bull. . 2009, 32: 993-8.

Zu Y., Liu L., Xu A., Lee M.Y.K., Lam K.S.L., Vanhoutte P.M.G.R. and Wang Y., SIRT1 promotes cell proliferation and prevents cellularr senescence in primary porcine endothelial cells, Fourth International Symposium on Healthy Aging of Research Centre of Heart, Brain, Hormone & Healthy Aging, March 7-8, 2009, Hong Kong. 2009.

Researcher : Xu Y

List of Research Outputs

Ng W.W.H., Keung W.W.Y., Xu Y., Ng J.K.F., Leung G.P.H., Vanhoutte P.M.G.R., Choy P.C. and Man R.Y.K., Genistein otentiates protein kinase A activity in porcine coronary artery, Mol Cell Biochem. 2008, 311: 37-44.

Researcher : Yan SC

List of Research Outputs

Sy L.K., Yan S.C., Lok C.N., Man R.Y.K. and Che C.M., Timosaponin A-III Indues Autophagy Preceding Mitochondria-Mediated Apoptosis in HeLa Cancer Cells , Cancer Research. 2008, 68: 10229 -10237.

Researcher : Yang C

List of Research Outputs

Yang C., Kwan Y.W., Seto S.W. and Leung G.P.H., Inhibitory effects of epoxyeicosatrienoic acids on volume-activated chloride channels in rat mesenteric arterial smooth muscle, Prostaglandins and Other Lipid Mediator . 2008, 87: 62-67.

Researcher : Yap MML

List of Research Outputs

Tang J., Feng Y., Tong Y., Yap M.M.L. and Man R.Y.K., A distinct new microscopic feature for identification of the crude drug of Radix Angelicae Pubescentis, In: Editoral Board of Journal of Chinese Medicinal Materials, Journal of Chinese Medicinal Materials. Guangzhou, Central Station of Chineses Medicinal Materials, SFDA, 2008, 31(12): 1796-1802.

Researcher : Yu L

List of Research Outputs

Li P., Wu K.K., Wong H.P.S., Zhang S.T., Yu L. and Cho C.H., Chloroform extract of cigarette smoke induces proliferation of human esophageal squamous-cell carcinoma cells: modulation by beta-adrenoceptors, Drug and Chemical Toxicology. 2009, 32: 175-181.

Researcher : Zhou M

List of Research Outputs

Law K.M., Xu A., Lam K.S.L., Berger T.H.O.R.S.T.E.N., Mak T.A.K., Liu T.C., Sweeney G.A.R.Y., Zhou M. and Wang Y., Protection from obesity-induced insulin resistance in mice lacking lipocalin-2 , Fourth International Symposium on Healthy Aging. 2009.

Wang Y., Zhou M., Lam K.S.L. and Xu A., Protective roles of adiponectin in obesity-related fatty liver diseases: mechanisms and therapeutic implications., Arq Bras Endocrinol Metabol. . 2009, 53: 201-12.

Zhang X., Lam K.S.L., Zhou M., Chang J., Chung S.K. and Xu A., Inactivation Of Hypoxia Inducible Factor (hif) 1 Alpha Induces Obesity-associated Metabolic Disorders Through Brown Adipose Tissue Dysfunction , 14th Medical Research Conference-Hong Kong . 2009.

Zhang X., Zhou M., Chang J., Chung S.K., Xu A. and Lam K.S.L., Inactivation Of Hypoxia Inducible Factor 1apha Induces Obesity-associated Metabolic Disorders Through Brown Adipose Tissue Dysfunction , 1. The Annual Scientific Meeting of Hong Kong Society of Endocrinology Metabolism and Reproduction, 30th November 2008.

Zhou M., Xu A., Tam P.K.H., Lam K.S.L., Chan L., Hoo R.L.C., Liu J., Chow H.M. and Wang Y., Mitochondrial dysfunction contributes to the increased vulnerabilities of adiponectin knockout mice to liver injury., Hepatology. 2008, 48 (4): 1087-96.

Zhou M., Xu A., Tam P.K.H., Lam K.S.L., Chan L., Liu J., Chow H.M. and Wang Y., Mitochondrial dysfunction contributes to the increased vulnerabilities of adiponectin knockout mice to liver injury, Fourth International Symposium on Healthy Aging: "Emerging Therapies for an Aging Population". 2009.

Researcher : Zhou M

List of Research Outputs

Researcher : Zhu D

List of Research Outputs

Wan A.K.S., Leung S.W.S., Zhu D. and Man R.Y.K., Vascular effects of different lipophilic components of “danshen”, a traditional Chinese medicine, in the isolated porcine coronary artery, Journal of Natural Products. 2008, 71: 1825-1828.

Researcher : Zu Y

List of Research Outputs

Wang Y., Zu Y., Liu L., Lam K.S.L., Lee M.Y.K., Vanhoutte P.M.G.R. and Xu A., SIRT1 promotes cell proliferation and prevents cellular senescence through targeting LKB1 in primary cultures of porcine aortic endothelial cells, 10th International Symposium on Mechanisms of Vasodilatation. 2009.

Zu Y., Liu L., Xu A., Lee M.Y.K., Lam K.S.L., Vanhoutte P.M.G.R. and Wang Y., SIRT1 promotes cell proliferation and prevents cellularr senescence in primary porcine endothelial cells, Fourth International Symposium on Healthy Aging of Research Centre of Heart, Brain, Hormone & Healthy Aging, March 7-8, 2009, Hong Kong. 2009.

Researcher : Zu Y

List of Research Outputs

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