Dept of Biochemistry

DEPT OF BIOCHEMISTRY

Researcher : Au YK

List of Research Outputs

Au Y.K., Wynn S...L., Szeto Y.Y., Geng G...Y...H., Cheung K.M.C. and Cheah K.S.E., Mutant Sox9 exerts context dependent gain-of-function impact in a campomelic dysplasia mouse model, Gordon Research Conferences - 2009 Program (Cartilage Biology & Pathology). Les Diablerets Conference Center, Les Diablerets, Switzerland June 7-12,. 2009.

Cheah K.S.E., Au Y.K., Szeto Y.Y., Wynn S.L., Geng G.Y.H., Chan Y.S., Chan W.Y., Cheung K.M.C. and Fritzsch B., Illuminating the aetiology of Campomelic dysplasia caused by mutation in the transactivation domain of SOX9, Frontiers in Biomedical Research, Hong Kong December 12. 2008.

Cheah K.S.E., Au Y.K., Szeto Y.Y., Wynn S.L., Chan Y.S., Cheung K.M.C., Chan W.Y., Lovell-Badge R.H. and Fritzsch B., Insights into the function of SOX9 and campomelic dysplasia, American Society for Matrix Biology, 2008 Meeting, San Diego, California, USA, December 07-10. 2008.

Guo S., Wynn S...L., Au Y.K., Chan D., Fassler R. and Cheah K.S.E., The role of Cell-matrix interactions mediated by β1 integrin in notochord development and function, Gordon Research Conferences - 2009 Program Cartilage Biology & Pathology. Les Diablerets Conference Center, Les Diablerets, Switzerland June 7-12,. 2009.

Szeto Y.Y., Au Y.K., Wynn S., Chan Y.S., Lovell-Badge R., Chan W.Y., Fritzsch B. and Cheah K.S.E., Sensorineural Deafness in a mouse model of Campomelic Dysplasia, The 18th CDB Meeting, Common themes and New Concepts in Sensory Formation, RIKEN Center for Developmental Biology, April 13-16, Kobe, Japan . 2009.

Researcher : Cham WC

List of Research Outputs

Cham W.C., Ma C.W., Zhang Y., Xie H., Yung W.H., Chan Y.S. and Shum D.K.Y., Heparanase modulates synaptic plasticity at the hippocampus, Abstracts of 4th Int’l Symp. on Healthy Aging: Emerging Therapy for an Aging Population: 77. 2009.

Cham W.C., Ma C.W., Zhang Y., Chan Y.S. and Shum D.K.Y., Role of heparanase in synaptic plasticity at the hippocampus and the vestibular nucleus, Proc. 6th Asian Biophysics Association Symposium. 2009, 167-168.

Researcher : Chan CCY

List of Research Outputs

Cheah K.S.E., Chan C.C.Y., Choi M.Y., Tanner J.A., Luk K.D.K. and Chan D., Essential and dose-dependent requirement for the sedlin component of the trapp complex in development, Cold Spring Harbor Meeting on Mouse Genetics & Genomics: Development & Disease, Cold Sping Harbor, New York, USA, October 29 - November 2, 2008.

Researcher : Chan CH

List of Research Outputs

Chan C.H., Leung O.Y.V., Ip M.S.M. and Shum D.K.Y., HS/syndecan modulate proteolytic balance in airway inflammation, American Society for Matrix Biology, 2008 Meeting, San Diego, California, USA. December 07-10. 2008.

Chan C.H., Leung O.Y.V., Ip M.S.M. and Shum D.K.Y., Shed Syndecan-1 Restricts Neutrophil Elastase from alpha-1-Antitrypsin in Neutrophilic Airway Inflammation, American Journal of Respiratory Cell and Molecular Biology. 2009, 41: 620-628.

Chan K.H., Chan C.H., Ho S.P., Yeung S.C., Shum D.K.Y., Ip M.S.M., Man R.Y.K. and Mak J.C.W., Chinese green tea protects cigarette smoke-induced up-regulation of neutrophil elastase in rat lung, Am J Respir Crit Care Med. 2009, 179: A2022.

Chan K.H., Chan C.H., Ho S.P., Yeung S.C., Shum D.K.Y., Ip M.S.M., Man R.Y.K. and Mak J.C.W., Protection of cigarette smoke-induced up-regulation of neutrophil elastase by Chinese green tea in rat lung, 14th Medical Research Conference, Department of Medicine, HKU. Hong Kong Medical Journal. 2009, 15 (Supp 1): 8.

Leung O.Y.V., Chan C.H., Ip M.S.M. and Shum D.K.Y., The Potential Use of Heparinase-generated Heparin Fragments in the Treatment of Bronchiectasis and Chronic Obstructive Pulmonary Disease, 13th Research Postgraduate Symposium, Hong Kong December 10 & 11. 2008.

Researcher : Chan CP

List of Research Outputs

Chan C.P., 2009 Society for Chinese Bioscientists in America Travel Fellowship, Society for Chinese Bioscientists in America. 2009.

Chan C.P., American Society for Cell Biology Student Travel Award, American Society for Cell Biology. 2008.

Chan C.P., Graduate Student Travel Scholarship, Tigris Educational Fund. 2008.

Chan C.P., Mak T.Y., Chin K.T. and Jin D., Requirement of N-linked glycosylation in the luminal domain for optimal proteolytic activation of liver-enriched transcription factor, The 48th American Society for Cell Biology Annual Meeting, San Francisco. 2008.

Chan C.P., Siu Y.T. and Jin D., The role of CREB in Ras-induced expression of interleukin 8., 8th EMBL Transcription Meeting, EMBL Heidelberg. 2008.

Researcher : Chan CP

List of Research Outputs

Chan C.P., 2009 Society for Chinese Bioscientists in America Travel Fellowship, Society for Chinese Bioscientists in America. 2009.

Chan C.P., American Society for Cell Biology Student Travel Award, American Society for Cell Biology. 2008.

Chan C.P., Graduate Student Travel Scholarship, Tigris Educational Fund. 2008.

Chan C.P., Siu Y.T. and Jin D., The role of CREB in Ras-induced expression of interleukin 8., 8th EMBL Transcription Meeting, EMBL Heidelberg. 2008.

Researcher : Chan CP

List of Research Outputs

Chan C.P., 2009 Society for Chinese Bioscientists in America Travel Fellowship, Society for Chinese Bioscientists in America. 2009.

Chan C.P., American Society for Cell Biology Student Travel Award, American Society for Cell Biology. 2008.

Chan C.P., Graduate Student Travel Scholarship, Tigris Educational Fund. 2008.

Chan C.P., Siu Y.T. and Jin D., The role of CREB in Ras-induced expression of interleukin 8., 8th EMBL Transcription Meeting, EMBL Heidelberg. 2008.

Researcher : Chan CWW

List of Research Outputs

Leung Y.L., Chan C.W.W., Hung S.C., Cheung K.M.C. and Chan D., Implication of matrix remodeling during intervertebral disc growth and degeneration by multichromatic FAST staining, Journal of Histochemistry & Cytochemistry. 2009, 57(3): 249-256.

Lie Y.S., Chan C.W.W., Cheah K.S.E. and Chan D., Impact of Intracellular Clearance of unfolded Proteins on Chondrocytes Cell Fate, 13th Research Postgraduate Symposium, HKU December 10 & 11 . 2008.

Researcher : Chan CY

List of Research Outputs

Chan C.Y., The Role of sPdzd2 in Regulating Pancreatic Beta Cells, 13th Research Postgraduate Symposium, December 10 & 11, 2008.

Researcher : Chan D

List of Research Outputs

Aladin Kaderbatcha D.M., Lu W.W., Ngan A.H.W., Cheung K.M.C., Chan D. and Luk K.D.K., Nano-scale morphology of disc collagens and their correlation with disc mechanics, 28th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 29-30, 2008.

Chan B.P., Chan G.C.F., Wong H.L., Cheung P.T., Cheah K.S.E. and Chan D., Cell-matrix Microspheres, Methods For Preparatin And Applications 07872058.8 - 1223 Pct/ib2007004413, European Patent Office. 2008.

Chan C.W., Leung Y.L., Lu W.W., Chan D., Luk K.D.K. and Cheung K.M.C., Interveretebral disc cryopreservation, SICOT/SIROT 2008 XXIV Triennial World Congress, Hong Kong, August 24-28, 2008.

Chan W.C.W., Tsang K.Y., Cheng Y.W., Chik H.Y.H., Melhado I.G., Boyde A., Jones S., Cheah K.S.E. and Chan D., Activating ER-stress in differentiating osteocytes impairs maturation causing hyperostosis in mice, XXI Meeting of the Federation of the European Connective Tissue Societies, Marseille, France 9-13 July 2008.

Chan W.L., Chan D., Lee S., Cheah K.S.E. and Tanner J.A., Differential protein profiling of stressed chondrocytes and skeletal dysplasia disease, Human Proteomics Organisation (HUPO) Annual Meeting August 16-20, 2008, Amsterdam, Netherlands. 2008.

Chan W.L., Mundlos S., Kamak U., Cheah K.S.E. and Chan D., Molecular Basis for Gerodermia Osteodysplastica, a Prematured Aging Disorder, 13th Research Postgraduate Symposium, HKU, Hong Kong December 10 & 11. 2008.

Cheah K.S.E., Chan C.C.Y., Choi M.Y., Tanner J.A., Luk K.D.K. and Chan D., Essential and dose-dependent requirement for the sedlin component of the trapp complex in development, Cold Spring Harbor Meeting on Mouse Genetics & Genomics: Development & Disease, Cold Sping Harbor, New York, USA, October 29 - November 2, 2008.

Cheng H.W., Tsui K., Cheung K.M.C., Chan D. and Chan B.P., Decellularization of chondrocyte-encapsulated collagen microspheres - A 3D model to study the effects of acellular matrix on stem cell fate, Tissue Engineering, Part C. 2009, 15: 1-10.

Cheng H.W., Tsui Y.K., Cheung K.M.C., Chan D. and Chan B.P., Decellularization of chondrocyte-encapsulated collagen microspheres – A 3D model to study effects of acellular matrix on stem cell fate, Biomaterials Asia 2009. Hong Kong, PA16.

Cheung K.M.C., Karppinen J., Chan D., Fan B., Ho D.W.H., Kao P.Y.P., Song Y., Sham P.C., Cheah K.S.E., Leong J.C.Y. and Luk K.D.K., How has genetics changed our understanding of disc degeneration, SICOT/SIROT 2008 XXIV Triennial World Congress, Hong Kong, August 24-28, 2008.

Cheung K.M.C., Karppinen J., Chan D., Ho D.W.H., Song Y., Sham P.C., Cheah K.S.E., Leong J.C.Y. and Luk K.D.K., Prevalence and pattern of lumbar MRI changes in a population study of 1043 individuals, Spine. 2009, 34(9): 934-40.

Cheung M.C.H. and Chan D., Principles of Developmental Genetics, JAMA. 2008, 299(11): 1366-1367.

Gan H., Zhu G., Wang Z., Chan D., Cheah K.S.E. and Huang J., Study the function of KIF5B in long bone development, 13th Research Postgraduate Symposium, Hong Kong December 10 & 11. 2008.

Gan H., Zhu G., Chan D., Cheah K.S.E. and Huang J., The function of kinesin-1 mediated intracellular transportation in long bone development, Gordon Research Conferences - 2009 Program (Cartilage Biology & Pathology). Les Diablerets Conference Center, Les Diablerets, Switzerland June 7-12. 2009.

Gao B., Hu J., Stricker S., Cheung M.C.H., Ma G., Law K...F., Witte F., Briscoe J., Mundlos S., He L., Cheah K.S.E. and Chan D., A mutation in lhh that causes digit abnormalities alters its signalling capacity and range, Nature. 2009, 458(7242): 1196-200.

Gao Y., Leung W.L., Wong S.Y.Y., Chan D. and Cheah K.S.E., Type IIA Procollagen: A Regulator of Nodal Signaling, 13th Research Postgraduate Symposium, HKU December 10 & 11. 2008.

Garcia-Barcelo M.M., Tang S.M., Ngan E.S.W., Lui V.C.H., Chen Y., So M.T., Leon Y.Y., Miao X., Shum K.Y., Liu F., Yeung M.Y., Yuan Z.W., Guo W.H., Liu L., Sun X., Huang L.M., Tou J.F., Song Y.Q., Chan D., Cheung K.M.C., Wong K.K.Y., Cherny S.S., Sham P.C. and Tam P.K.H., Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung's disease, PNAS. 2009, 106(8): 2694-2699.

Guo S., Wynn S...L., Au Y.K., Chan D., Fassler R. and Cheah K.S.E., The role of Cell-matrix interactions mediated by β1 integrin in notochord development and function, Gordon Research Conferences - 2009 Program Cartilage Biology & Pathology. Les Diablerets Conference Center, Les Diablerets, Switzerland June 7-12,. 2009.

Huang S., Cheung K.M.C., Long D., Lin H., Luk K.D.K., Chan D. and Zhou G., Isolation and characterization of cell subpopulation with stem Cell properties in human and monkey intervertebral disc (IVD), Xth European Cell & Materials (ECM) Conference: Stem Cells for Musculoskeletal Regeneration. AO Foundation, Davos, 2009.

Lam T.K., Chan D., Cheah K.S.E. and Song Y., In Vivo Study Of Asporin Polymorphic Variants In Chondrogenesis And Degenerative Skeletal Diseases, 13th Research Postgraduate Symposium, Hong Kong December 10 & 11. 2008.

Lam T.K., Chan D., Cheah K.S.E. and Song Y., In vivo Study of Asporin Polymorphic Variants in Chondrogenesis and Degenerative Skeletal Diseases, Matrix Biology Society of Australia and New Zealand (MBSANZ), October 13-16. NSW, Australia, 2008.

Leung Y.L., Hung S.C., Chan Li L.C., Wu E.X., Luk K.D.K., Chan D. and Cheung K.M.C., Age-related degeneration of lumbar intervertebral discs in rabbits revealed by deuterium oxide-assisted MRI, Osteoarthritis and Cartilage. 2008, 16 (11): 1312-8.

Leung Y.L., Chan W.C.W., Hung S.C., Cheung K.M.C. and Chan D., Implication of matrix remodeling during intervertebral disc growth and degeneration by multichromatic FAST staining, 55th Annual Meeting of the Orthopaedic Research Society, Las Vegas, USA, February 22-25, 2009.

Leung Y.L., Chan C.W.W., Hung S.C., Cheung K.M.C. and Chan D., Implication of matrix remodeling during intervertebral disc growth and degeneration by multichromatic FAST staining, Journal of Histochemistry & Cytochemistry. 2009, 57(3): 249-256.

Li Y.Y., Cheng H.W., Chan P.M., Wong M.Y., Chan D. and Chan B.P., Collagen-mesenchymal stem cell microspheres for cartilage tissue engineering, Biomaterials Asia 2009. Hong Kong, OD02.

Lie Y.S., Chan C.W.W., Cheah K.S.E. and Chan D., Impact of Intracellular Clearance of unfolded Proteins on Chondrocytes Cell Fate, 13th Research Postgraduate Symposium, HKU December 10 & 11 . 2008.

Sham P.C., Cherny S.S., Kao P.Y.P., Song Y., Chan D. and Cheung K.M.C., (iii) Whole-genome association studies of complex diseases, Current Orthopaedics. 2008, 22: 251-258.

Tam P.K.H., Tang S.M., Ngan E.S.W., Lui V.C.H., Chen Y., So M.T., Leon Y.Y., Miao X., Shum K.Y., Liu F., Yeung M.Y., Yuan Z.W., Guo W.H., Liu L., Sun X., Huang L.M., Tou J.F., Song Y.Q., Chan D., Cheung K.M.C., Wong K.K.Y., Cherny S.S., Sham P.C. and Garcia-Barcelo M.M., Genome-wide association study identifies NRG1 as a susceptibility locus for Hirschsprung's disease (Invited Lecture), The 2nd International Symposium: Develoopment of the Enteric Nervous System: Cells, Signals and Genes, UCL Institute of Child Health, London, U.K., 22-25 February 2009. 2009.

Tsui Y.K., Leung Y.L., Kao R.Y.T., Masuda K., Chan D. and Cheung K.M.C., Identifying therapeutic chemical agents for osteoarthritis by high throughput screening, 55th Annual Meeting of the Orthopaedic Research Society, Las Vegas, USA, February 22-25, 2009.

Wang C., Tsang K.Y., Chan D. and Cheah K.S.E., Best Poster: the Roles Of Chop And Gadd34 In The Adaptation Of Hypertrophic Chondrocytes To Er Stress , , Gordon Conference (cartilage Biology & Pathology). 2009.

Wang C., Tsang K.Y., Chan D. and Cheah K.S.E., The Roles of CHOP and GADD34 in the Adaptation of Hypertrophic Chondrocytes to ER Stress, Gordon Research Conferences - 2009 Program (Cartilage Biology & Pathology). Les Diablerets Conference Center, Les Diablerets, Switzerland June 7-12. 2009.

Yang F., Leung Y.L., Chan D., Luk K.D.K. and Cheung K.M.C., A histological grading system for evaluating disc degeneration in the mouse, 55th Annual Meeting of the Orthopaedic Research Society, Las Vegas, USA, February 22-25, 2009.

Yang F., Chan D., Leung Y.L., Lu W.W., Luk K.D.K. and Cheung K.M.C., In vivo chondrocytic differentiation of the allogenic stem cells in the murine intervertebral disc, SICOT/SIROT 2008 XXIV Triennial World Congress, Hong Kong, August 24-28, 2008.

Yang F., Leung Y.L., Luk K.D.K., Chan D. and Cheung K.M.C., Injury-induced sequential transformation of notochordal nucleus pulposus to chondrogenic and fibrocartilaginous phenotype in the mouse, Journal of Pathology. 2009, 218(1): 113-21.

Yee F.Y.A., Melhado I.G., Lam P.Y., Chu I.K., Grad S., Alini M., Cheah K.S.E., Cheung K.M.C. and Chan D., Protein and Gene Expression Profiles of the Intervertebral Disc in Health and Disease, Gordon Research Conferences - 2009 Program (Cartilage Biology & Pathology). Les Diablerets Conference Center, Les Diablerets, Switzerland June 7-12. 2009.

Yeung C.W., Cheah K.S.E., Chan D. and Chan B.P., Three dimensional culture and chondrogenic differentiation of mouse embryonic stem cells, Biomaterials Asia 2009. Hong Kong, OB01.

Yeung C.W., Chan D., Cheah K.S.E. and Chan B.P., Three dimensional culture and embryoid body-free chondrogenic differentiation of mouse embryonic stem cells in collagen microspheres, Tissue Engineering, Part A. 2009, 15: 1-15.

Yeung K.W.K., Chan Y.L., Lu W.W., Luk K.D.K., Chan D., Wu S.L., Liu X.M., Chu C.L., Chung C.Y., Chu P.K., Cheung K.M.C. and Chung C.Y., Formation of CAP04 and suppression of Ni leaching in nitinol using oxygen and sodium plasma immersion ion implantation, SICOT/SIROT 2008 XXIV Triennial World Congress, Hong Kong, August 24-28, 2008.

Yeung K.W.K., Chan Y.L., Lu W.W., Luk K.D.K., Chan D., Wu S.L., Liu X.M., Chu C.L. and Chung C.Y., Formation of CaPO4 and Suppression of Ni Leaching in Nitinol using Oxygen and Sodium Plasma Immersion Ion Implantation, SICOT/SIROT 2008 XXIV Triennial World Congress, Hong Kong (24-28, Aug, 2008). 2008.

Yeung M.N., Zhou Z., Chan D. and Shum D.K.Y., A Novel Non-invasive Role of Heparanase: Promotion of Cartilage Matrix Mineralization, 13th Research Postgraduate Symposium, HKU. December 10 & 11, 2008, Hong Kong. 2008.

Researcher : Chan JKM

List of Research Outputs

West M.A., Prescott A.R., Chan J.K.M., Zhou Z., Rose-John S., Scheller J. and Watts C., Tlr Ligand-induced Podosome Disassembly In Dendritic Cells Is Adam17 Dependent, J Cell Biol.. USA, 2008, 182: 993-1005.

Researcher : Chan SLC

List of Research Outputs

Chan S.L.C., Sclerostin - A Negative regulator Of Bone Formation And A Target For Osteoporosis Therapy, PhD Thesis. 2009.

Researcher : Chan SY

List of Research Outputs

Tang L.F., Cheung C.L., Sham P.C., McClurg P., Lee B.B.C., Chan S.Y., Smith D.K., Tanner J.A., Su A.I., Cheah K.S.E., Kung A.W.C. and Song Y., Genome-wide haplotype association mapping in mice identifies a genetic variant in CER1 associated with bone mineral density and fracture in southern Chinese women., J Bone Miner Res . 2008, 24(6): 1013-21.

Researcher : Chan WCW

List of Research Outputs

Chan W.C.W., Tsang K.Y., Cheng Y.W., Chik H.Y.H., Melhado I.G., Boyde A., Jones S., Cheah K.S.E. and Chan D., Activating ER-stress in differentiating osteocytes impairs maturation causing hyperostosis in mice, XXI Meeting of the Federation of the European Connective Tissue Societies, Marseille, France 9-13 July 2008.

Leung Y.L., Chan W.C.W., Hung S.C., Cheung K.M.C. and Chan D., Implication of matrix remodeling during intervertebral disc growth and degeneration by multichromatic FAST staining, 55th Annual Meeting of the Orthopaedic Research Society, Las Vegas, USA, February 22-25, 2009.

Researcher : Chan WL

List of Research Outputs

Chan W.L., A Proteomics Study to Reveal the Molecular Response to Protein Misfolding in Chondrocytes, Ph.D. thesis. 2009.

Chan W.L., Chan D., Lee S., Cheah K.S.E. and Tanner J.A., Differential protein profiling of stressed chondrocytes and skeletal dysplasia disease, Human Proteomics Organisation (HUPO) Annual Meeting August 16-20, 2008, Amsterdam, Netherlands. 2008.

Chan W.L., Mundlos S., Kamak U., Cheah K.S.E. and Chan D., Molecular Basis for Gerodermia Osteodysplastica, a Prematured Aging Disorder, 13th Research Postgraduate Symposium, HKU, Hong Kong December 10 & 11. 2008.

Researcher : Chan WL

List of Research Outputs

Chan W.L., A Proteomics Study to Reveal the Molecular Response to Protein Misfolding in Chondrocytes, Ph.D. thesis. 2009.

Researcher : Chan WL

List of Research Outputs

Chan W.L., A Proteomics Study to Reveal the Molecular Response to Protein Misfolding in Chondrocytes, Ph.D. thesis. 2009.

Researcher : Chan WY

List of Research Outputs

Chan W.Y., Mouse Model with Impaired Matrx Degradation at the Chondro-osseous Junction, PhD Thesis. 2009.

Cheah K.S.E., Au Y.K., Szeto Y.Y., Wynn S.L., Geng G.Y.H., Chan Y.S., Chan W.Y., Cheung K.M.C. and Fritzsch B., Illuminating the aetiology of Campomelic dysplasia caused by mutation in the transactivation domain of SOX9, Frontiers in Biomedical Research, Hong Kong December 12. 2008.

Cheah K.S.E., Au Y.K., Szeto Y.Y., Wynn S.L., Chan Y.S., Cheung K.M.C., Chan W.Y., Lovell-Badge R.H. and Fritzsch B., Insights into the function of SOX9 and campomelic dysplasia, American Society for Matrix Biology, 2008 Meeting, San Diego, California, USA, December 07-10. 2008.

Szeto Y.Y., Au Y.K., Wynn S., Chan Y.S., Lovell-Badge R., Chan W.Y., Fritzsch B. and Cheah K.S.E., Sensorineural Deafness in a mouse model of Campomelic Dysplasia, The 18th CDB Meeting, Common themes and New Concepts in Sensory Formation, RIKEN Center for Developmental Biology, April 13-16, Kobe, Japan . 2009.

Researcher : Chan WY

List of Research Outputs

Chan W.Y., Mouse Model with Impaired Matrx Degradation at the Chondro-osseous Junction, PhD Thesis. 2009.

Researcher : Cheah KSE

List of Research Outputs

Au Y.K., Wynn S...L., Szeto Y.Y., Geng G...Y...H., Cheung K.M.C. and Cheah K.S.E., Mutant Sox9 exerts context dependent gain-of-function impact in a campomelic dysplasia mouse model, Gordon Research Conferences - 2009 Program (Cartilage Biology & Pathology). Les Diablerets Conference Center, Les Diablerets, Switzerland June 7-12,. 2009.

Chan B.P., Chan G.C.F., Wong H.L., Cheung P.T., Cheah K.S.E. and Chan D., Cell-matrix Microspheres, Methods For Preparatin And Applications 07872058.8 - 1223 Pct/ib2007004413, European Patent Office. 2008.

Chan W.C.W., Tsang K.Y., Cheng Y.W., Chik H.Y.H., Melhado I.G., Boyde A., Jones S., Cheah K.S.E. and Chan D., Activating ER-stress in differentiating osteocytes impairs maturation causing hyperostosis in mice, XXI Meeting of the Federation of the European Connective Tissue Societies, Marseille, France 9-13 July 2008.

Chan W.L., Chan D., Lee S., Cheah K.S.E. and Tanner J.A., Differential protein profiling of stressed chondrocytes and skeletal dysplasia disease, Human Proteomics Organisation (HUPO) Annual Meeting August 16-20, 2008, Amsterdam, Netherlands. 2008.

Chan W.L., Mundlos S., Kamak U., Cheah K.S.E. and Chan D., Molecular Basis for Gerodermia Osteodysplastica, a Prematured Aging Disorder, 13th Research Postgraduate Symposium, HKU, Hong Kong December 10 & 11. 2008.

Cheah K.S.E., Cell fate determination in skeletal development., 2008 Seminar Series in Cell Biology-Subcellular Structures and Cellular Dynamics. HKU-Pasteur Research Centre, The University of Hong Kong, Hong Kong , November 25-26. 2008.

Cheah K.S.E., Context dependent impact of Sox9 campomelic dysplasia mutation, Sox Meeting, Awaji Island, Japan September 16-19. 2008.

Cheah K.S.E., Context dependent impact of Sox9 campomelic dysplasia mutation, Sox Meeting, Awaji Island, Japan. September 16-19, 2008, Invited speaker. 2008.

Cheah K.S.E., Chan C.C.Y., Choi M.Y., Tanner J.A., Luk K.D.K. and Chan D., Essential and dose-dependent requirement for the sedlin component of the trapp complex in development, Cold Spring Harbor Meeting on Mouse Genetics & Genomics: Development & Disease, Cold Sping Harbor, New York, USA, October 29 - November 2, 2008.

Cheah K.S.E., Genetic variation and degenerative skeletal disorders: intervertebral disc disease as a case study., HUGO HVP Forum 2008. September16-19 . 2008.

Cheah K.S.E., Au Y.K., Szeto Y.Y., Wynn S.L., Geng G.Y.H., Chan Y.S., Chan W.Y., Cheung K.M.C. and Fritzsch B., Illuminating the aetiology of Campomelic dysplasia caused by mutation in the transactivation domain of SOX9, Frontiers in Biomedical Research, Hong Kong December 12. 2008.

Cheah K.S.E., Au Y.K., Szeto Y.Y., Wynn S.L., Chan Y.S., Cheung K.M.C., Chan W.Y., Lovell-Badge R.H. and Fritzsch B., Insights into the function of SOX9 and campomelic dysplasia, American Society for Matrix Biology, 2008 Meeting, San Diego, California, USA, December 07-10. 2008.

Cheung K.M.C., Karppinen J., Chan D., Fan B., Ho D.W.H., Kao P.Y.P., Song Y., Sham P.C., Cheah K.S.E., Leong J.C.Y. and Luk K.D.K., How has genetics changed our understanding of disc degeneration, SICOT/SIROT 2008 XXIV Triennial World Congress, Hong Kong, August 24-28, 2008.

Cheung K.M.C., Karppinen J., Chan D., Ho D.W.H., Song Y., Sham P.C., Cheah K.S.E., Leong J.C.Y. and Luk K.D.K., Prevalence and pattern of lumbar MRI changes in a population study of 1043 individuals, Spine. 2009, 34(9): 934-40.

Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Sox10 mutation affects inner ear gliogenesis and morphogenesis, The 7th Molecular Biology of Hearing and Deafness. Harvard Medical School. Boston, June 20-23, USA. 2009.

Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Cheah K.S.E. and Sham M.H., The Role of Sox 10 in Mouse Inner Ear Development, 13th Research Postgraduate Symposium, HKU December 10 & 11. 2008.

Dabdoub A., Puligilla C., Jones J...M..., Fritzsch B..., Cheah K.S.E., Pevny L...H. and Kelley M...W., Sox2 signaling in prosensory domain specification and subsequent hair cell differentiation in the developing cochlea, Proc Natl. Acad. Sci. (USA) Epub. 2008, 105: 18396-401.

Francois M., Caprini A., Hosking B., Orsenigo F., Wilhelm D., Browne C., Paavonen K., Karnezis T., Shayan R., Downes M., Davidson T., Tutt D., Cheah K.S.E., Stacker S...A., Muscat G...E., Achen M...G., Dejana E. and Koopman P., Sox18 induces development of the lymphatic vasculature in mice, Nature. 2008, 456(7222): 643-7.

Gan H., Zhu G., Wang Z., Chan D., Cheah K.S.E. and Huang J., Study the function of KIF5B in long bone development, 13th Research Postgraduate Symposium, Hong Kong December 10 & 11. 2008.

Gan H., Zhu G., Chan D., Cheah K.S.E. and Huang J., The function of kinesin-1 mediated intracellular transportation in long bone development, Gordon Research Conferences - 2009 Program (Cartilage Biology & Pathology). Les Diablerets Conference Center, Les Diablerets, Switzerland June 7-12. 2009.

Gao B., Hu J., Stricker S., Cheung M.C.H., Ma G., Law K...F., Witte F., Briscoe J., Mundlos S., He L., Cheah K.S.E. and Chan D., A mutation in lhh that causes digit abnormalities alters its signalling capacity and range, Nature. 2009, 458(7242): 1196-200.

Gao Y., Leung W.L., Wong S.Y.Y., Chan D. and Cheah K.S.E., Type IIA Procollagen: A Regulator of Nodal Signaling, 13th Research Postgraduate Symposium, HKU December 10 & 11. 2008.

Guo S., Wynn S...L., Au Y.K., Chan D., Fassler R. and Cheah K.S.E., The role of Cell-matrix interactions mediated by β1 integrin in notochord development and function, Gordon Research Conferences - 2009 Program Cartilage Biology & Pathology. Les Diablerets Conference Center, Les Diablerets, Switzerland June 7-12,. 2009.

Ho D.W.H., Cheung K.M.C., Karppinen J., Yip S.P., Ott J., Luk K.D.K., Leong J.C.Y., Cheah K.S.E., Sham P.C. and Song Y., Linkage Analysis With Subsequent Fine-mapping On Familial Early-onset Degenerative Disc Disease, The 10th International Meeting on Human Genome Variation Toronto, Canada http://www.tcag.ca/hgv2008/. 2008.

Kwong W.H. and Cheah K.S.E., Functional Analyses of Type IIA Procollagen in Mouse Inner Ear Development, 13th Research Postgraduate Symposium, HKU. Hong Kong December 10 & 11. 2008.

Lam T.K., Chan D., Cheah K.S.E. and Song Y., In Vivo Study Of Asporin Polymorphic Variants In Chondrogenesis And Degenerative Skeletal Diseases, 13th Research Postgraduate Symposium, Hong Kong December 10 & 11. 2008.

Lam T.K., Chan D., Cheah K.S.E. and Song Y., In vivo Study of Asporin Polymorphic Variants in Chondrogenesis and Degenerative Skeletal Diseases, Matrix Biology Society of Australia and New Zealand (MBSANZ), October 13-16. NSW, Australia, 2008.

Lie Y.S., Chan C.W.W., Cheah K.S.E. and Chan D., Impact of Intracellular Clearance of unfolded Proteins on Chondrocytes Cell Fate, 13th Research Postgraduate Symposium, HKU December 10 & 11 . 2008.

Mak C.Y.A., Szeto Y.Y. and Cheah K.S.E., Differential and Overlapping Expression of SOX2 and SOX9 in Inner Ear Development, 13th Research Postgraduate Symposium, HKU. Hong Kong December 10 & 11. 2008.

Mak C.Y.A., Szeto Y.Y., Fritzsch B. and Cheah K.S.E., Differential and Overlapping Expression of SOX2 and SOX9 in Inner Ear Development, Common Themes and New Concerpts in Sensory Formation April13-15 2009 Kobe, Japan. 2008.

Song Y., Tang L.F., Wong S.Y.Y., Leung W.L., Sham P.C. and Cheah K.S.E., Genetic Modifier(s) Of Embryonic Lethality In Type Iia Procollagen Deficient Mice , 58th Annual Meeting of The American Society of Human Genetics http://www.ashg.org/2008meeting/ Philadelphia, USA. Nov 11-15. 2008.

Szeto Y.Y., Au Y.K., Wynn S., Chan Y.S., Lovell-Badge R., Chan W.Y., Fritzsch B. and Cheah K.S.E., Sensorineural Deafness in a mouse model of Campomelic Dysplasia, The 18th CDB Meeting, Common themes and New Concepts in Sensory Formation, RIKEN Center for Developmental Biology, April 13-16, Kobe, Japan . 2009.

Szeto Y.Y., Leung K.K.H., Sham M.H. and Cheah K.S.E., Utility of Hoxb2 Enhancer-mediated Cre Activity for Functional Studies in the Developing Inner ear, Common Themes and New Concepts in Sensory Formation, April 13-15 2009, Kobe, Japan . 2008.

Szeto Y.Y., Leung K.K.H., Sham M.H. and Cheah K.S.E., Utility of Hoxb2 enhancer - mediated Cre activity for functional studies in the developing inner ear, Genesis. 2009, 47(6): 361-365.

Tang L.F., Cheung C.L., Sham P.C., McClurg P., Lee B.B.C., Chan S.Y., Smith D.K., Tanner J.A., Su A.I., Cheah K.S.E., Kung A.W.C. and Song Y., Genome-wide haplotype association mapping in mice identifies a genetic variant in CER1 associated with bone mineral density and fracture in southern Chinese women., J Bone Miner Res . 2008, 24(6): 1013-21.

Tang L.F., Cheah K.S.E., Sham P.C. and Song Y., Mapping a genetic modifier for heart defects in Type IIA procollagen deficient mutant mice, Best Poster, New Developments in Quantitative Molecular Bioscience, Greece, 10-17 September, 2008. 2008.

Tang L.F., Cheah K.S.E. and Song Y., Mapping a genetic modifier for heart defects in Type IIA procollagen deficient mutant mice, New Developments in Quantitative Molecular Bioscience. Island of Spetses, Greece, 2008.

Wang C., Tsang K.Y., Chan D. and Cheah K.S.E., Best Poster: the Roles Of Chop And Gadd34 In The Adaptation Of Hypertrophic Chondrocytes To Er Stress , , Gordon Conference (cartilage Biology & Pathology). 2009.

Wang C., Tsang K.Y., Chan D. and Cheah K.S.E., The Roles of CHOP and GADD34 in the Adaptation of Hypertrophic Chondrocytes to ER Stress, Gordon Research Conferences - 2009 Program (Cartilage Biology & Pathology). Les Diablerets Conference Center, Les Diablerets, Switzerland June 7-12. 2009.

Wong E.Y.M., Fritzsch B., Wu D.K., Chan Y.S., Cheah K.S.E. and Sham M.H., Over-expression of Hoxb3 affects inner ear neurogenesis, The 27th Hong Kong Society of Neuroscience Annual Meeting, Hong Kong. 2008.

Wong E.Y.M., Chan Y.S., Cheah K.S.E. and Sham M.H., Over-expression of Hoxb3 affects sensory neuron differentiation and inner ear morphogenesis., 32nd Annual Midwinter Research Meeting, Association for Research in Otolaryngology, USA. . 2009.

Yee F.Y.A., Melhado I.G., Lam P.Y., Chu I.K., Grad S., Alini M., Cheah K.S.E., Cheung K.M.C. and Chan D., Protein and Gene Expression Profiles of the Intervertebral Disc in Health and Disease, Gordon Research Conferences - 2009 Program (Cartilage Biology & Pathology). Les Diablerets Conference Center, Les Diablerets, Switzerland June 7-12. 2009.

Yeung C.W., Cheah K.S.E., Chan D. and Chan B.P., Three dimensional culture and chondrogenic differentiation of mouse embryonic stem cells, Biomaterials Asia 2009. Hong Kong, OB01.

Yeung C.W., Chan D., Cheah K.S.E. and Chan B.P., Three dimensional culture and embryoid body-free chondrogenic differentiation of mouse embryonic stem cells in collagen microspheres, Tissue Engineering, Part A. 2009, 15: 1-15.

Researcher : Chee DMC

List of Research Outputs

Chee D.M.C., Studying the roles of conserved domains of the transcription factor Sox 10 in neural crest development, MPhil Thesis. 2008.

Sham M.H., Zhang M., Chu K.H., Wong E.Y.M., Chee D.M.C., Cheung M.C.H., Lui V.C.H. and Tam P.K.H., A Novel Sox10-NGFP mouse model of waardenburg_Hirschsprung Syndrome, Neurogastroenterol. 2009, 21(2): XXI.

Sham M.H., Zhang M., Chu K.H., Wong E.Y.M., Chee D.M.C., Cheung M.C.H., Lui V.C.H. and Tam P.K.H., A novel Sox10-NGFP mouse model of Waardenburg-Hirschsprung Syndrome, The 2nd International Symposium on the Development of the Enteric Nervous System, London, U.K.. 2009.

Researcher : Cheng CCW

List of Research Outputs

Chow E.S.H., Hui N.Y.H., Cheng C.C.W. and Cheng S.H., Cadmium affects retinogenesis 8431ba54a75d994aac14300f">Toxicology and Applied Pharmacology. Elsevier, 2009, 235: 68-76.

Researcher : Cheng MH

List of Research Outputs

Cheng M.H., Choy R.K.W., Zheng C., Tsang W.H., Tsang S.L., Song Y., Pang C.P. and Sham M.H., A _γA-crystallin Mouse Mutant Secc with Small Eye, Cataract and Closed Eyelid, 13th Research Postgraduate Symposium, HKU December 10 & 11. 2008.

Researcher : Cheung MCH

List of Research Outputs

Cheung M.C.H. and Chan D., Principles of Developmental Genetics, JAMA. 2008, 299(11): 1366-1367.

Gao B., Hu J., Stricker S., Cheung M.C.H., Ma G., Law K...F., Witte F., Briscoe J., Mundlos S., He L., Cheah K.S.E. and Chan D., A mutation in lhh that causes digit abnormalities alters its signalling capacity and range, Nature. 2009, 458(7242): 1196-200.

Sham M.H., Zhang M., Chu K.H., Wong E.Y.M., Chee D.M.C., Cheung M.C.H., Lui V.C.H. and Tam P.K.H., A Novel Sox10-NGFP mouse model of waardenburg_Hirschsprung Syndrome, Neurogastroenterol. 2009, 21(2): XXI.

Sham M.H., Zhang M., Chu K.H., Wong E.Y.M., Chee D.M.C., Cheung M.C.H., Lui V.C.H. and Tam P.K.H., A novel Sox10-NGFP mouse model of Waardenburg-Hirschsprung Syndrome, The 2nd International Symposium on the Development of the Enteric Nervous System, London, U.K.. 2009.

Researcher : Chik HYH

List of Research Outputs

Chan W.C.W., Tsang K.Y., Cheng Y.W., Chik H.Y.H., Melhado I.G., Boyde A., Jones S., Cheah K.S.E. and Chan D., Activating ER-stress in differentiating osteocytes impairs maturation causing hyperostosis in mice, XXI Meeting of the Federation of the European Connective Tissue Societies, Marseille, France 9-13 July 2008.

Researcher : Chin KT

List of Research Outputs

Chan C.P., Mak T.Y., Chin K.T. and Jin D., Requirement of N-linked glycosylation in the luminal domain for optimal proteolytic activation of liver-enriched transcription factor, The 48th American Society for Cell Biology Annual Meeting, San Francisco. 2008.

Researcher : Choi MY

List of Research Outputs

Cheah K.S.E., Chan C.C.Y., Choi M.Y., Tanner J.A., Luk K.D.K. and Chan D., Essential and dose-dependent requirement for the sedlin component of the trapp complex in development, Cold Spring Harbor Meeting on Mouse Genetics & Genomics: Development & Disease, Cold Sping Harbor, New York, USA, October 29 - November 2, 2008.

Choi M.Y., Functional Studies On Sedlin And Its Involvement In Spondyloepiphyseal Dysplasia Tarda, PhD Thesis. 2008.

Researcher : Choi MY

List of Research Outputs

Choi M.Y., Functional Studies On Sedlin And Its Involvement In Spondyloepiphyseal Dysplasia Tarda, PhD Thesis. 2008.

Researcher : Choy YWE

List of Research Outputs

Choy Y.W.E., Siu K.L., Kok K.H., Lung R.W.M., Tsang C.M., To K.F., Kwong D.L.W., Tsao G.S.W. and Jin D., An Epstein-Barr virus-encoded microRNA targets PUMA to promote host cell survival, Journal of Experimental Medicine. 2008, 205: 2551-2560.

Researcher : Chu KH

List of Research Outputs

Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Sox10 mutation affects inner ear gliogenesis and morphogenesis, The 7th Molecular Biology of Hearing and Deafness. Harvard Medical School. Boston, June 20-23, USA. 2009.

Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Cheah K.S.E. and Sham M.H., The Role of Sox 10 in Mouse Inner Ear Development, 13th Research Postgraduate Symposium, HKU December 10 & 11. 2008.

Sham M.H., Zhang M., Chu K.H., Wong E.Y.M., Chee D.M.C., Cheung M.C.H., Lui V.C.H. and Tam P.K.H., A Novel Sox10-NGFP mouse model of waardenburg_Hirschsprung Syndrome, Neurogastroenterol. 2009, 21(2): XXI.

Sham M.H., Zhang M., Chu K.H., Wong E.Y.M., Chee D.M.C., Cheung M.C.H., Lui V.C.H. and Tam P.K.H., A novel Sox10-NGFP mouse model of Waardenburg-Hirschsprung Syndrome, The 2nd International Symposium on the Development of the Enteric Nervous System, London, U.K.. 2009.

Researcher : Chun CS

List of Research Outputs

Chun C.S. and Jin D., REV7-mediated polyubiquitination and degradation of human REV1. , 4th Intracellular Proteolysis Meeting: Ubiquitin-Proteosome System, Dynamics and Targeting (A Biochemical Society Meeting), Barcelona, Spain. 2009.

Researcher : Cui J

List of Research Outputs

Cui J., Wang Z., Zeng Q.N., Leung P.S., Yao K.M. and Huang J., Investigation of the Role of Kif5B in Pancreatic β-cells Function, 13th Research Postgraduate Symposium, December 10 & 11, 2008.

Researcher : Danchin ALM

List of Research Outputs

Miao Y., Danchin A.L.M. and Huang J., Visualizing the Proteome Escherichia coli by Recombineering Technology, 13th Research Postgraduate Symposium, HKU, Hong Kong, December 10 & 11. 2008.

Researcher : Fan B

List of Research Outputs

Cheung K.M.C., Karppinen J., Chan D., Fan B., Ho D.W.H., Kao P.Y.P., Song Y., Sham P.C., Cheah K.S.E., Leong J.C.Y. and Luk K.D.K., How has genetics changed our understanding of disc degeneration, SICOT/SIROT 2008 XXIV Triennial World Congress, Hong Kong, August 24-28, 2008.

Researcher : Gan H

List of Research Outputs

Gan H., Zhu G., Wang Z., Chan D., Cheah K.S.E. and Huang J., Study the function of KIF5B in long bone development, 13th Research Postgraduate Symposium, Hong Kong December 10 & 11. 2008.

Gan H., Zhu G., Chan D., Cheah K.S.E. and Huang J., The function of kinesin-1 mediated intracellular transportation in long bone development, Gordon Research Conferences - 2009 Program (Cartilage Biology & Pathology). Les Diablerets Conference Center, Les Diablerets, Switzerland June 7-12. 2009.

Researcher : Gao B

List of Research Outputs

Gao B., Hu J., Stricker S., Cheung M.C.H., Ma G., Law K...F., Witte F., Briscoe J., Mundlos S., He L., Cheah K.S.E. and Chan D., A mutation in lhh that causes digit abnormalities alters its signalling capacity and range, Nature. 2009, 458(7242): 1196-200.

Researcher : Gao Y

List of Research Outputs

Gao Y., Leung W.L., Wong S.Y.Y., Chan D. and Cheah K.S.E., Type IIA Procollagen: A Regulator of Nodal Signaling, 13th Research Postgraduate Symposium, HKU December 10 & 11. 2008.

Researcher : Guo S

List of Research Outputs

Guo S., Wynn S...L., Au Y.K., Chan D., Fassler R. and Cheah K.S.E., The role of Cell-matrix interactions mediated by β1 integrin in notochord development and function, Gordon Research Conferences - 2009 Program Cartilage Biology & Pathology. Les Diablerets Conference Center, Les Diablerets, Switzerland June 7-12,. 2009.

Researcher : Ho DWH

List of Research Outputs

Cheung K.M.C., Karppinen J., Chan D., Fan B., Ho D.W.H., Kao P.Y.P., Song Y., Sham P.C., Cheah K.S.E., Leong J.C.Y. and Luk K.D.K., How has genetics changed our understanding of disc degeneration, SICOT/SIROT 2008 XXIV Triennial World Congress, Hong Kong, August 24-28, 2008.

Cheung K.M.C., Karppinen J., Chan D., Ho D.W.H., Song Y., Sham P.C., Cheah K.S.E., Leong J.C.Y. and Luk K.D.K., Prevalence and pattern of lumbar MRI changes in a population study of 1043 individuals, Spine. 2009, 34(9): 934-40.

Ho D.W.H., Genetic Study of Lumbar Disc Degeneration, PhD Thesis. 2009.

Ho D.W.H., Cheung K.M.C., Karppinen J., Yip S.P., Ott J., Luk K.D.K., Leong J.C.Y., Cheah K.S.E., Sham P.C. and Song Y., Linkage Analysis With Subsequent Fine-mapping On Familial Early-onset Degenerative Disc Disease, The 10th International Meeting on Human Genome Variation Toronto, Canada http://www.tcag.ca/hgv2008/. 2008.

Samartzis D., Karppinen J., Mok P.S., Ho D.W.H., Fong D.Y.T., Luk K.D.K. and Cheung K.M.C., "Skipped" level disc degeneration of the lumbar spine, Global Spine Congress, San Francisco, USA, June 23-26, 2009.

Samartzis D., Karppinen J., Mok P.S., Ho D.W.H., Fong D.Y.T., Luk K.D.K. and Cheung K.M.C., Juvenile disc degeneration of the lumbar spine: prevalence, risk factors and clinical relevance, Global Spine Congress, San Francisco, USA, June 23-26, 2009.

Researcher : Ho DWH

List of Research Outputs

Ho D.W.H., Genetic Study of Lumbar Disc Degeneration, PhD Thesis. 2009.

Researcher : Hu J

List of Research Outputs

Gao B., Hu J., Stricker S., Cheung M.C.H., Ma G., Law K...F., Witte F., Briscoe J., Mundlos S., He L., Cheah K.S.E. and Chan D., A mutation in lhh that causes digit abnormalities alters its signalling capacity and range, Nature. 2009, 458(7242): 1196-200.

Researcher : Huang J

List of Research Outputs

Chan C.M., Tse H., Wong S.S.Y., Woo P.C.Y., Lau S.K.P., Chen L., Zheng B., Huang J. and Yuen K.Y., Examination of seroprevalence of coronavirus HKU1 infection with S protein-based ELISA and neutralization assay against viral spike pseudotyped virus. , J Clin Virol. 2009, 45(1): 54-60.

Chan C.M., Lau S.K.P., Woo P.C.Y., Tse H., Zheng B., Chen L., Huang J. and Yuen K.Y., Identification of Major Histocompatibility Antigen Class I C as an attachment coreceptor that facilitates Coronavirus HKU1 Spike-mediated infection, J Viral . 2009, 16(1): 45-52.

Chan C.M., Woo P.C.Y., Lau S.K.P., Tse H., Chen H., Li F., Zheng B., Chen L., Huang J. and Yuen K.Y., Spike protein, S, of human coronavirus HKU1: role in viral life cycle and application in antibody detection, Exp Biol Med (Maywood). 2008, 33 (12): 1527-1536.

Cui J., Wang Z., Zeng Q.N., Leung P.S., Yao K.M. and Huang J., Investigation of the Role of Kif5B in Pancreatic β-cells Function, 13th Research Postgraduate Symposium, December 10 & 11, 2008.

Gan H., Zhu G., Wang Z., Chan D., Cheah K.S.E. and Huang J., Study the function of KIF5B in long bone development, 13th Research Postgraduate Symposium, Hong Kong December 10 & 11. 2008.

Gan H., Zhu G., Chan D., Cheah K.S.E. and Huang J., The function of kinesin-1 mediated intracellular transportation in long bone development, Gordon Research Conferences - 2009 Program (Cartilage Biology & Pathology). Les Diablerets Conference Center, Les Diablerets, Switzerland June 7-12. 2009.

He M.L., Zheng B., Chen Y., Wong K.L., Huang J., Lin M.C., Yuen K.Y., Sung J.J. and Kung H.F., Development of Interfering RNA Agents to Inhibit SARS-associated Coronavirus Infection and Replication, Hong Kong Medical Journal. 2009, Suppl 4: S28-31.

Huang J., Chen G. and Hwa T., Bronze Award, International Genetically Engineered Machine Competition 2008, MIT, Microsoft Corporation. 2008.

Huang J., Formation of new patterns by programming cell motility, First International Frontiers in Synthetic Biology 2008, Meeting ‘Synthetic Biology: Engineering Genes, Genomes & Cells for Drug Discovery’, Boston, MA, U.S.A.) 1-2 December 2008 . 2008.

Huang J., Zheng B. and Sun H., Helicases as antiviral drug targets., Hong Kong Med J. 2008, 14(4, Suppl 4): 36-38.

Huang J., Program cell motility to form novel patterns, Applied Industrial Synthetic Biology in Europe - Status Quo and Perspectives, April 15-16, 2009, Freiburg, Germany. 2009.

Huang J., Program cell motility to form novel patterns, Shanghai Institutes for Biological Sciences Shanghai, Chinese Academy of Science, Shanghai, China . 2009.

Jin Y., Watt R.M., Danchin A. and Huang J., Small noncoding RNA GcvB is a novel regulator of acid resistance in Escherichia coli, BMC Genomics. 2009, 10: 165-171.

Lin R., Fung M.L. and Huang J., Reduced Neuronal Nitric Oxide Production from KIF5B-deficiency Mice, 13th Research Postgraduate Symposium, HKU December 10 & 11. 2008.

Lin R., Fung M.L. and Huang J., Reduced neuronal nitric oxide production from KIF5B-deficiency mice, 13th Research Postgraduate Symposium, HKU. 2008, P1.21.

Lu S., Lu L., Guan X.Y. and Huang J., Pdss2 Conditional Knockout Mouse Model, 13th Research Postgraduate Symposium, Hong Kong December 10 & 11. 2008.

Miao Y., Danchin A.L.M. and Huang J., Visualizing the Proteome Escherichia coli by Recombineering Technology, 13th Research Postgraduate Symposium, HKU, Hong Kong, December 10 & 11. 2008.

Sui H., Zhao G., Huang J., Jin D., Yuen K.Y. and Zheng B., Small Interfering RNA Targeting M2 Gene Induces Effective and Long term Inhibition of Influenza A Virus Replication. , PloS One. 2009, 4(5): e5671.

Woo P.C.Y., Lau S.K.P., Tse H., Teng L.L., Curreem O.T.S., Tsang K.L., Fan Y.Y., Wong K.M.G., Huang Y., Loman N.J., Snyder L.A., Cai J., Huang J., Mak W.W., Pallen M.J., Lok S. and Yuen K.Y., The complete genome and proteome of Laribacter hongkongensis reveal potential mechanisms for adaptations to different temperatures and habitats, PLoS Genetics. 2009, 5: e1000416.

Yu B., Yuen K.Y., Zheng B. and Huang J., Development of Salmonella-mediated Oral Vaccine against Avian Influenza Viruses H5N1, 13th Research Postgraduate Symposium, HKU. Hong Kong December 10 & 11. 2008.

Zheng B., Zhou J., Huang J., Lu L. and Yuen K.Y., An IFN-a/b receptor 1 promoter variant and hepatitis B virus synergistically increase the susceptibility to chronic hepatitis B, 2008 International Meeting: The Molecular Biology of Hepatitis B Viruses. San Diego, California, USA, 2008.

Zheng B., Guan Y., Huang J. and He M.L., Synthetic Peptide Targeting Critical Sites on the SARS-Associated Coronaviurs Spike Protein Responsible for Viral Infection and a Method of Use Thereof, U.S. Patent No. 7,491,489. 2009.

Zhou J., Chen D., Poon K.M., Zeng Y., Ng F., Lu L., Huang J., Yuen K.Y. and Zheng B., A comprehensive study of interferon-γ receptor 1 gene polymorphisms and susceptibility to chronic hepatitis B virus infection. , Immunogenetics. 2009, 61(6): 423-430.

Zhou J., Smith D.K., Lu L., Poon K.M., Ng F., Chen D., Huang J., Yuen K.Y. and Zheng B., A non-synonymous single nucleotide polymorphism in IFNAR1 affects susceptibility to chronic hepatitis B virus infection, J Viral Hepat. 2009, 16(1): 45-52.

Zhou J., Huang J., Poon V.K.M., Chen D.Q., Chan C.C.S., Ng F., Guan X.Y., Watt R.M., Lu L., Yuen K.Y. and Zheng B., Functional dissection of an IFN-α/β receptor 1 promoter variant that confers higher risk to chronic hepatitis B virus infection , Journal of Hepatology. 2009, V51(2): 322-32.

Researcher : Jin D

List of Research Outputs

Chan C.P., Mak T.Y., Chin K.T. and Jin D., Requirement of N-linked glycosylation in the luminal domain for optimal proteolytic activation of liver-enriched transcription factor, The 48th American Society for Cell Biology Annual Meeting, San Francisco. 2008.

Chan C.P., Siu Y.T. and Jin D., The role of CREB in Ras-induced expression of interleukin 8., 8th EMBL Transcription Meeting, EMBL Heidelberg. 2008.

Choy Y.W.E., Siu K.L., Kok K.H., Lung R.W.M., Tsang C.M., To K.F., Kwong D.L.W., Tsao G.S.W. and Jin D., An Epstein-Barr virus-encoded microRNA targets PUMA to promote host cell survival, Journal of Experimental Medicine. 2008, 205: 2551-2560.

Chun C.S. and Jin D., REV7-mediated polyubiquitination and degradation of human REV1. , 4th Intracellular Proteolysis Meeting: Ubiquitin-Proteosome System, Dynamics and Targeting (A Biochemical Society Meeting), Barcelona, Spain. 2009.

Jang W.C., Kok K.H., Jin D., Wong D.S.H. and Lo A.C.Y., Effects of Down-Regulating Hypoxia-Inducible Factor-1 Alpha on Retinal Pigment Epithelial Cells Under Hypoxia, ARVO 2009 Annual Meeting. 2009.

Jang W.C., Kok K.H., Jin D., Wong D.S.H. and Lo A.C.Y., The role of hypoxia-inducible factor-1 in choroidal neovascularization, The 27th Hong Kong Society of Neuroscience Annual Meeting. 2009.

Jin D., Epstein-Barr virus encodes an antiapoptotic microRNA that inhibits Epstein-Barr virus encodes an antiapoptotic microRNA that inhibits PUMA to promote tumor cell survival. , Frontiers in Biomedical Research, HKU2008. 2008.

Jin D., Epstein-Barr virus encodes an antiapoptotic microRNA to inhibit PUMA and promote tumor cell survival, Cancer 2009: MicroRNA in Cancer Development. The 5th Asia Pacific Multidisciplinary Meeting for Cancer Research. The Chinese University of Hong Kong, Hong Kong. 2009.

Jin D., Outstanding Researcher Award 2008-2009, University of Hong Kong. 2008.

Jin D., Viral modulation of cellular signaling through SARS coronavirus structural proteins, Emerging Infectious Disease Workshop, National Taiwan University Hospital. 2008.

Jin D., miR-BART5 is an anti-apoptotic miRNA encoded by EBV and inhibits PUMA to promote host cell survival. , The 20th Federation of Asian and Ocean Biochemists and Molecular Biologists (FAOBMB), Taipei, Taiwan. 2008.

Jin D., miR-BART5 is an anti-apoptotic miRNA encoded by EBV and inhibits PUMA to promote host cell survival, EBV Symposium 2008 (Thirteenth Biennial Symposium of the International Association for Research on Epstein-Barr Virus and Associated Diseases), Guangzhou, China. 2008.

Ng M.H., Siu K.L., Ching Y.P. and Jin D., Roles and Regulation of MIPT3 in Interferon Signaling, 13th Research Postgraduate Symposium, HKU. Hong Kong December 10 & 11. 2008.

Siu K.L., Kok K.H., Ng M.H., Poon K.M., Yuen K.Y., Zheng B. and Jin D., Severe acute respiratory syndrome coronavirus M protein inhibits type I interferon production by impeding the formation of TRAF3.TANK.TBK1/IKKepsilon complex., Journal of Biological Chemistry. 2009, 284: 16202-16209.

Siu Y.T., Ching Y.P. and Jin D., Activation of TORC1 transcriptional coactivator through MEKK1-induced phosphorylation, Molecular Biology Of The Cell. 2008, 19: 4750-61.

Siu Y.T. and Jin D., Activation of TORCI transcriptional Coactivator Through MEKKI-induced Phosphorylation and Ubiquitination, 13th Research Postgraduate Symposium, HKU. Hong Kong, December 10 & 11. 2008.

Siu Y.T. and Jin D., MEKK1-induced phosphorylation and activation of TORC1 transcriptional coactivator, 8th EMBL Transcription Meeting, EMBL Heidelberg, Germany. 2008.

Sui H., Zhao G., Huang J., Jin D., Yuen K.Y. and Zheng B., Small Interfering RNA Targeting M2 Gene Induces Effective and Long term Inhibition of Influenza A Virus Replication. , PloS One. 2009, 4(5): e5671.

Sze M.F., Ching Y.P., Jin D. and Ng I.O.L., Role of a novel splice variant of mitotic arrest deficient 1 (MAD1), MAD1beta, in mitotic checkpoint control in liver cancer, In: American Association for Cancer Research, Cancer Research. 2008, 68: 9194-9201.

Tang H.M.V., Siu K.L., Wong C.M. and Jin D., Loss of Yeast Peroxiredoxin TSAI Induces Genome Instability Through Constitutive Activation of DNA Damage Checkpoint and Elevation of Cellular dNTP Levels, 13th Research Postgraduate Symposium, HKU. Hong Kong December 10 & 11. 2008.

Tang H.M.V., Siu K.L., Wong C.M. and Jin D., Loss of peroxiredoxin Tsa1p induces genome instability through activation of DNA damage checkpoint and elevation of dNTP levels., 3rd American Society for Microbiology Conference on DNA Repair and Mutagenesis. Fairmont Chateau Whistler, Whistler, BC, Canada. 2009.

Tsao G.S.W., Tsang C.M., Zhang G., Hau P.M., Man C.W.Y., Yip Y.L., Lee L.S., Seto E., Takada K., Cao Y., Chen H., Lo K.W., Jin D. and Kwong D.L.W., Establishment of stable infection of Epstein-Barr Virus in premalignant nasopharyngeal epithelial cells, Proceedings of EBV Symposium. 2008.

Yau T.O., Chan C.F., Lam S.G.S., Cheung O.F., Ching Y.P., Jin D., Sham M.H. and Ng I.O.L., Hepatocyte-specific activation of NF-KB does not aggravate chemical hepatocarcinogenesis in transgenic mice, The Journal of Pathology. 2008, 217: 353-361.

Zheng B., Du L., Zhao G., Lin Y., Sui H., Chan C.S., Ma S., He Y., Jiang S., Wu C., Jin D., Zhou Y. and Yuen K.Y., SARS-CoV S Protein Induces Strong Mucosal Immune Responses and Provides Long-term Protection Against SARS-CoV Infection. , Vaccine 2nd Congress. Boston, MA, USA, 2008.

Researcher : Jin G

List of Research Outputs

Jin G. and Zhou Z., MTI-MMP Supports Development Niche of B Cell Lineage in Bone Marrow, 13th Research Postgraduate Symposium, HKU. Hong Kong December 10 & 11. 2008.

Researcher : Jin Y

List of Research Outputs

Jin Y., Watt R.M., Danchin A. and Huang J., Small noncoding RNA GcvB is a novel regulator of acid resistance in Escherichia coli, BMC Genomics. 2009, 10: 165-171.

Researcher : Kao PYP

List of Research Outputs

Cheung K.M.C., Karppinen J., Chan D., Fan B., Ho D.W.H., Kao P.Y.P., Song Y., Sham P.C., Cheah K.S.E., Leong J.C.Y. and Luk K.D.K., How has genetics changed our understanding of disc degeneration, SICOT/SIROT 2008 XXIV Triennial World Congress, Hong Kong, August 24-28, 2008.

Li M., Jiang L., Kao P.Y.P., Sham P.C. and Song Y., IGG3: a tool to rapidly integrate large genotype datasets for whole-genome imputation and individual-level meta-analysis, Bioinformatics. 2009, 25 (11): 1449-1450.

Sham P.C., Cherny S.S., Kao P.Y.P., Song Y., Chan D. and Cheung K.M.C., (iii) Whole-genome association studies of complex diseases, Current Orthopaedics. 2008, 22: 251-258.

Researcher : Kimura M

List of Research Outputs

Kimura M. and Tanner J.A., Delivery of SCV Helicase Aptamers Using Cationic Lipidic Systems, 13th Research Postgraduate Symposium, HKU. Hong Kong. December 10 & 11. 2008.

Researcher : Kok KH

List of Research Outputs

Choy Y.W.E., Siu K.L., Kok K.H., Lung R.W.M., Tsang C.M., To K.F., Kwong D.L.W., Tsao G.S.W. and Jin D., An Epstein-Barr virus-encoded microRNA targets PUMA to promote host cell survival, Journal of Experimental Medicine. 2008, 205: 2551-2560.

Jang W.C., Kok K.H., Jin D., Wong D.S.H. and Lo A.C.Y., Effects of Down-Regulating Hypoxia-Inducible Factor-1 Alpha on Retinal Pigment Epithelial Cells Under Hypoxia, ARVO 2009 Annual Meeting. 2009.

Jang W.C., Kok K.H., Jin D., Wong D.S.H. and Lo A.C.Y., The role of hypoxia-inducible factor-1 in choroidal neovascularization, The 27th Hong Kong Society of Neuroscience Annual Meeting. 2009.

Siu K.L., Kok K.H., Ng M.H., Poon K.M., Yuen K.Y., Zheng B. and Jin D., Severe acute respiratory syndrome coronavirus M protein inhibits type I interferon production by impeding the formation of TRAF3.TANK.TBK1/IKKepsilon complex., Journal of Biological Chemistry. 2009, 284: 16202-16209.

Researcher : Kong CT

List of Research Outputs

Wu X., Kong C.T. and Zhou Z., Functional Analysis of the Mouse Isthmin Gene Encoding a Novel Secreted Protein, 13th Research Postgraduate Symposium, HKU. Hong Kong. December 10 & 11. 2008.

Researcher : Kwong WH

List of Research Outputs

Kwong W.H. and Cheah K.S.E., Functional Analyses of Type IIA Procollagen in Mouse Inner Ear Development, 13th Research Postgraduate Symposium, HKU. Hong Kong December 10 & 11. 2008.

Researcher : Lam D

List of Research Outputs

Lam D. and Wong N.S., An Investigation of the Mutual Relationship between ER Stress and Oxidative Stress, 13th Research Postgraduate Symposium, HKU December 10 & 11. 2008.

Researcher : Lam TK

List of Research Outputs

Lam T.K., Chan D., Cheah K.S.E. and Song Y., In Vivo Study Of Asporin Polymorphic Variants In Chondrogenesis And Degenerative Skeletal Diseases, 13th Research Postgraduate Symposium, Hong Kong December 10 & 11. 2008.

Lam T.K., In vivo Study of Asporin Polymorphic Variants in Chondrogenesis and Degenerative Disc Disease (DDD), M.Phil Thesis. 2009.

Lam T.K., Chan D., Cheah K.S.E. and Song Y., In vivo Study of Asporin Polymorphic Variants in Chondrogenesis and Degenerative Skeletal Diseases, Matrix Biology Society of Australia and New Zealand (MBSANZ), October 13-16. NSW, Australia, 2008.

Researcher : Lam TK

List of Research Outputs

Lam T.K., In vivo Study of Asporin Polymorphic Variants in Chondrogenesis and Degenerative Disc Disease (DDD), M.Phil Thesis. 2009.

Researcher : Lee BBC

List of Research Outputs

Tang L.F., Cheung C.L., Sham P.C., McClurg P., Lee B.B.C., Chan S.Y., Smith D.K., Tanner J.A., Su A.I., Cheah K.S.E., Kung A.W.C. and Song Y., Genome-wide haplotype association mapping in mice identifies a genetic variant in CER1 associated with bone mineral density and fracture in southern Chinese women., J Bone Miner Res . 2008, 24(6): 1013-21.

Researcher : Lee S

List of Research Outputs

Chan W.L., Chan D., Lee S., Cheah K.S.E. and Tanner J.A., Differential protein profiling of stressed chondrocytes and skeletal dysplasia disease, Human Proteomics Organisation (HUPO) Annual Meeting August 16-20, 2008, Amsterdam, Netherlands. 2008.

Researcher : Leong JCY

List of Research Outputs

Cheung K.M.C., Karppinen J., Chan D., Ho D.W.H., Song Y., Sham P.C., Cheah K.S.E., Leong J.C.Y. and Luk K.D.K., Prevalence and pattern of lumbar MRI changes in a population study of 1043 individuals, Spine. 2009, 34(9): 934-40.

Researcher : Leung C

List of Research Outputs

Zhang M., Leung C., Lui V.C.H., Tam P.K.H. and Sham M.H., Abnormal enteric nervous system development in a Sox10^NGFPmouse mutant, Neurogastroenterol. 2009, 21(2): XVIII.

Zhang M., Leung C., Lui V.C.H., Tam P.K.H. and Sham M.H., Abnormal enteric nervous systemdevelopment in a Sox10-NGFP mutant mouse, The 6th Asian Biophysics Association Symposium and the 27th Hong Kong Society of Neuroscience Annual Meeting, Hong Kong, 11 - 15 January 2009.

Researcher : Leung KKH

List of Research Outputs

Szeto Y.Y., Leung K.K.H., Sham M.H. and Cheah K.S.E., Utility of Hoxb2 Enhancer-mediated Cre Activity for Functional Studies in the Developing Inner ear, Common Themes and New Concepts in Sensory Formation, April 13-15 2009, Kobe, Japan . 2008.

Szeto Y.Y., Leung K.K.H., Sham M.H. and Cheah K.S.E., Utility of Hoxb2 enhancer - mediated Cre activity for functional studies in the developing inner ear, Genesis. 2009, 47(6): 361-365.

Researcher : Leung OYV

List of Research Outputs

Chan C.H., Leung O.Y.V., Ip M.S.M. and Shum D.K.Y., HS/syndecan modulate proteolytic balance in airway inflammation, American Society for Matrix Biology, 2008 Meeting, San Diego, California, USA. December 07-10. 2008.

Chan C.H., Leung O.Y.V., Ip M.S.M. and Shum D.K.Y., Shed Syndecan-1 Restricts Neutrophil Elastase from alpha-1-Antitrypsin in Neutrophilic Airway Inflammation, American Journal of Respiratory Cell and Molecular Biology. 2009, 41: 620-628.

Leung O.Y.V., Chan C.H., Ip M.S.M. and Shum D.K.Y., The Potential Use of Heparinase-generated Heparin Fragments in the Treatment of Bronchiectasis and Chronic Obstructive Pulmonary Disease, 13th Research Postgraduate Symposium, Hong Kong December 10 & 11. 2008.

Researcher : Leung WL

List of Research Outputs

Gao Y., Leung W.L., Wong S.Y.Y., Chan D. and Cheah K.S.E., Type IIA Procollagen: A Regulator of Nodal Signaling, 13th Research Postgraduate Symposium, HKU December 10 & 11. 2008.

Song Y., Tang L.F., Wong S.Y.Y., Leung W.L., Sham P.C. and Cheah K.S.E., Genetic Modifier(s) Of Embryonic Lethality In Type Iia Procollagen Deficient Mice , 58th Annual Meeting of The American Society of Human Genetics http://www.ashg.org/2008meeting/ Philadelphia, USA. Nov 11-15. 2008.

Researcher : Li M

List of Research Outputs

Li M., Jiang L., Kao P.Y.P., Sham P.C. and Song Y., IGG3: a tool to rapidly integrate large genotype datasets for whole-genome imputation and individual-level meta-analysis, Bioinformatics. 2009, 25 (11): 1449-1450.

Li M., Sham P.C. and Song Y., KGG: A Systematic Biological Knowledge-based Mining System for Genome-wide Genetic Studies, 13th Research Postgraduate Symposium, HKU. Hong Kong December 10 & 11. 2008.

Li M., Jiang L., Sham P.C. and Song Y., Power of transmission/disequilibrium tests in admixed populations, Genetic Epidemiology. 2008, 32: 434-444.

Li M., Chan Y.S. and Shum D.K.Y., The Role of Chondroitin Sulfate Moieties on Cranial Motor Neuron Migration in the Developing Hindbrain of Rates, 13th Research Postgraduate Symposium, HKU. Hong Kong December 10 & 11. 2008.

Li M., Chan Y.S. and Shum D.K.Y., The expression of chondroitin sulfates in rat embryonic hindbrain and their roles on the lateral migration of trigeminal motor neurons, Proc. 6th Asian Biophysics Association Symposium. 2009, 143-144.

Li M., Chan Y.S. and Shum D.K.Y., The restrictive role of chondroitin sulfate moieties on the lateral migration of trigeminal motor neurons during hindbrain development in rats, Soc. Neuroscience Abstract (USA), 29.14/C57. [Washington DC. Nov. 15-19, 2008]. 2008.

Li M., Chan Y.S. and Shum D.K.Y., The role of chondroitin sulfate moieties on trigeminal motor neuron migration in embryonic rat hindbrain, Abstracts of 4th Int’l Symp. on Healthy Aging: Emerging Therapy for an Aging Population: 80. 2009.

Li M., Cheng T.S., Ho W.L., Chan K.H., Mak W., Cheung R.T.F., Ramsden D.B., Sham P.C., Song Y. and Ho S.L., –459C>T point mutation in 5' non-coding region of human GJB1 gene is linked to X-linked Charcot-Marie-Tooth neuropathy. , Journal of the Peripheral Nervous System. J Peripher Nerv Syst, 2009, 14: 14-21.

Researcher : Li M

List of Research Outputs

Li M., Jiang L., Sham P.C. and Song Y., Power of transmission/disequilibrium tests in admixed populations, Genetic Epidemiology. 2008, 32: 434-444.

Researcher : Li M

List of Research Outputs

Li M., Jiang L., Sham P.C. and Song Y., Power of transmission/disequilibrium tests in admixed populations, Genetic Epidemiology. 2008, 32: 434-444.

Researcher : Li M

List of Research Outputs

Li M., Jiang L., Sham P.C. and Song Y., Power of transmission/disequilibrium tests in admixed populations, Genetic Epidemiology. 2008, 32: 434-444.

Researcher : Li Y

List of Research Outputs

Li Y., Chu L.W., Li Z., Yik P.Y. and Song Y., A study on the association of the chromosome 12p13 locus with sporadic late-onset Alzheimer's disease in Chinese., Dement Geriatr Cogn Disord. Epub, 2009, 27(6): 508-12.

Li Y., Chu L.W. and Song Y., Cholesterol and genetics of Alzheimer¡¦s disease, Alzheimer's Association 2009 International Conference on Alzheimer's Disease (ICAD). 2009.

Li Y., Chu L.W., Cheung B.M.Y., Leung Y.H., Yik P.Y. and Song Y., Genetic Analysis of Alzheimer’s Disease Associated Genes – A Perspective from Abnormal Cholesterol Metabolism . Fourth international symposium on healthy aging, 2009.

Researcher : Li Y

List of Research Outputs

Li Y., Chu L.W. and Song Y., Cholesterol and genetics of Alzheimer¡¦s disease, Alzheimer's Association 2009 International Conference on Alzheimer's Disease (ICAD). 2009.

Researcher : Lie YS

List of Research Outputs

Lie Y.S., Chan C.W.W., Cheah K.S.E. and Chan D., Impact of Intracellular Clearance of unfolded Proteins on Chondrocytes Cell Fate, 13th Research Postgraduate Symposium, HKU December 10 & 11 . 2008.

Researcher : Lin R

List of Research Outputs

Lin R., Fung M.L. and Huang J., Reduced Neuronal Nitric Oxide Production from KIF5B-deficiency Mice, 13th Research Postgraduate Symposium, HKU December 10 & 11. 2008.

Lin R., Fung M.L. and Huang J., Reduced neuronal nitric oxide production from KIF5B-deficiency mice, 13th Research Postgraduate Symposium, HKU. 2008, P1.21.

Researcher : Lin R

List of Research Outputs

Lin R., Fung M.L. and Huang J., Reduced Neuronal Nitric Oxide Production from KIF5B-deficiency Mice, 13th Research Postgraduate Symposium, HKU December 10 & 11. 2008.

Lin R., Fung M.L. and Huang J., Reduced neuronal nitric oxide production from KIF5B-deficiency mice, 13th Research Postgraduate Symposium, HKU. 2008, P1.21.

Researcher : Liu B

List of Research Outputs

Zhou S., Liu B. and Zhou Z., B Cell Development Defect in ZMPSTE24^-/-Mice, 13th Research Postgraduate Symposium, HKU. Hong Kong December 10 & 11. 2008.

Researcher : Lovell-Badge RH

List of Research Outputs

Cheah K.S.E., Au Y.K., Szeto Y.Y., Wynn S.L., Chan Y.S., Cheung K.M.C., Chan W.Y., Lovell-Badge R.H. and Fritzsch B., Insights into the function of SOX9 and campomelic dysplasia, American Society for Matrix Biology, 2008 Meeting, San Diego, California, USA, December 07-10. 2008.

Researcher : Lu L

List of Research Outputs

Lu S., Lu L., Guan X.Y. and Huang J., Pdss2 Conditional Knockout Mouse Model, 13th Research Postgraduate Symposium, Hong Kong December 10 & 11. 2008.

Researcher : Lu S

List of Research Outputs

Lu S., Lu L., Guan X.Y. and Huang J., Pdss2 Conditional Knockout Mouse Model, 13th Research Postgraduate Symposium, Hong Kong December 10 & 11. 2008.

Researcher : Mak CYA

List of Research Outputs

Mak C.Y.A., Szeto Y.Y. and Cheah K.S.E., Differential and Overlapping Expression of SOX2 and SOX9 in Inner Ear Development, 13th Research Postgraduate Symposium, HKU. Hong Kong December 10 & 11. 2008.

Mak C.Y.A., Szeto Y.Y., Fritzsch B. and Cheah K.S.E., Differential and Overlapping Expression of SOX2 and SOX9 in Inner Ear Development, Common Themes and New Concerpts in Sensory Formation April13-15 2009 Kobe, Japan. 2008.

Researcher : Mak TY

List of Research Outputs

Chan C.P., Mak T.Y., Chin K.T. and Jin D., Requirement of N-linked glycosylation in the luminal domain for optimal proteolytic activation of liver-enriched transcription factor, The 48th American Society for Cell Biology Annual Meeting, San Francisco. 2008.

Researcher : Melhado IG

List of Research Outputs

Chan W.C.W., Tsang K.Y., Cheng Y.W., Chik H.Y.H., Melhado I.G., Boyde A., Jones S., Cheah K.S.E. and Chan D., Activating ER-stress in differentiating osteocytes impairs maturation causing hyperostosis in mice, XXI Meeting of the Federation of the European Connective Tissue Societies, Marseille, France 9-13 July 2008.

Yee F.Y.A., Melhado I.G., Lam P.Y., Chu I.K., Grad S., Alini M., Cheah K.S.E., Cheung K.M.C. and Chan D., Protein and Gene Expression Profiles of the Intervertebral Disc in Health and Disease, Gordon Research Conferences - 2009 Program (Cartilage Biology & Pathology). Les Diablerets Conference Center, Les Diablerets, Switzerland June 7-12. 2009.

Researcher : Miao Y

List of Research Outputs

Miao Y., Danchin A.L.M. and Huang J., Visualizing the Proteome Escherichia coli by Recombineering Technology, 13th Research Postgraduate Symposium, HKU, Hong Kong, December 10 & 11. 2008.

Researcher : Ng MH

List of Research Outputs

Ng M.H., Siu K.L., Ching Y.P. and Jin D., Roles and Regulation of MIPT3 in Interferon Signaling, 13th Research Postgraduate Symposium, HKU. Hong Kong December 10 & 11. 2008.

Ng M.H., Society of Chinese Bioscientists in America Travel Fellowship 2009, Society of Chinese Bioscientists in America. 2009.

Siu K.L., Kok K.H., Ng M.H., Poon K.M., Yuen K.Y., Zheng B. and Jin D., Severe acute respiratory syndrome coronavirus M protein inhibits type I interferon production by impeding the formation of TRAF3.TANK.TBK1/IKKepsilon complex., Journal of Biological Chemistry. 2009, 284: 16202-16209.

Researcher : Ng MH

List of Research Outputs

Ng M.H., Siu K.L., Ching Y.P. and Jin D., Roles and Regulation of MIPT3 in Interferon Signaling, 13th Research Postgraduate Symposium, HKU. Hong Kong December 10 & 11. 2008.

Ng M.H., Society of Chinese Bioscientists in America Travel Fellowship 2009, Society of Chinese Bioscientists in America. 2009.

Researcher : Sham MH

List of Research Outputs

Au-yeung K.L., Sze K.Y., Sham M.H. and Chan B.P., Development of a micromanipulator-based loading device for mechanoregulation study of human mesenchymal stem cells in 3D collagen constructs, Tissue Engineering, Part C. 2009, 15: 1-15.

Cheng M.H., Choy R.K.W., Zheng C., Tsang W.H., Tsang S.L., Song Y., Pang C.P. and Sham M.H., A _γA-crystallin Mouse Mutant Secc with Small Eye, Cataract and Closed Eyelid, 13th Research Postgraduate Symposium, HKU December 10 & 11. 2008.

Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Sox10 mutation affects inner ear gliogenesis and morphogenesis, The 7th Molecular Biology of Hearing and Deafness. Harvard Medical School. Boston, June 20-23, USA. 2009.

Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Cheah K.S.E. and Sham M.H., The Role of Sox 10 in Mouse Inner Ear Development, 13th Research Postgraduate Symposium, HKU December 10 & 11. 2008.

Lui V.C.H., Poon H.C., Ngan E.S.W., Sit F.Y.L., Hui C.C., Wainwright B.J., Sham M.H. and Tam P.K.H., Condition Ptc 1 knockout in vagal neural crest cells causes intestinal hypoganglionosis (Invited Lecture), The 2nd International Symposium, Development of the Enteric Nervous System: Cells, Signals and Genes, UCL Institute of Child Health, London, U.K., 22-25 February 2009. 2009.

Sham M.H., Zhang M., Chu K.H., Wong E.Y.M., Chee D.M.C., Cheung M.C.H., Lui V.C.H. and Tam P.K.H., A Novel Sox10-NGFP mouse model of waardenburg_Hirschsprung Syndrome, Neurogastroenterol. 2009, 21(2): XXI.

Sham M.H., Zhang M., Chu K.H., Wong E.Y.M., Chee D.M.C., Cheung M.C.H., Lui V.C.H. and Tam P.K.H., A novel Sox10-NGFP mouse model of Waardenburg-Hirschsprung Syndrome, The 2nd International Symposium on the Development of the Enteric Nervous System, London, U.K.. 2009.

Sham M.H., Congenital cataract: Characterization of a mouse model, World Ophthalmology Congress 2008. 2008.

Sham M.H., Faculty Teaching Medal , 2008.

Sham M.H., Member of the Academic Editorial Board, PLoS ONE. PLoS, 2008.

Sham M.H., Stem cell based therapy, Public Lecture Series 2008, Hong Kong Central Library. 2008.

Szeto Y.Y., Leung K.K.H., Sham M.H. and Cheah K.S.E., Utility of Hoxb2 Enhancer-mediated Cre Activity for Functional Studies in the Developing Inner ear, Common Themes and New Concepts in Sensory Formation, April 13-15 2009, Kobe, Japan . 2008.

Szeto Y.Y., Leung K.K.H., Sham M.H. and Cheah K.S.E., Utility of Hoxb2 enhancer - mediated Cre activity for functional studies in the developing inner ear, Genesis. 2009, 47(6): 361-365.

Wong E.Y.M., Fritzsch B., Wu D.K., Chan Y.S., Cheah K.S.E. and Sham M.H., Over-expression of Hoxb3 affects inner ear neurogenesis, The 27th Hong Kong Society of Neuroscience Annual Meeting, Hong Kong. 2008.

Wong E.Y.M., Chan Y.S., Cheah K.S.E. and Sham M.H., Over-expression of Hoxb3 affects sensory neuron differentiation and inner ear morphogenesis., 32nd Annual Midwinter Research Meeting, Association for Research in Otolaryngology, USA. . 2009.

Yau T.O., Chan C.F., Lam S.G.S., Cheung O.F., Ching Y.P., Jin D., Sham M.H. and Ng I.O.L., Hepatocyte-specific activation of NF-KB does not aggravate chemical hepatocarcinogenesis in transgenic mice, The Journal of Pathology. 2008, 217: 353-361.

Zhang M., Leung C., Lui V.C.H., Tam P.K.H. and Sham M.H., Abnormal enteric nervous system development in a Sox10^NGFPmouse mutant, Neurogastroenterol. 2009, 21(2): XVIII.

Zhang M., Leung C., Lui V.C.H., Tam P.K.H. and Sham M.H., Abnormal enteric nervous systemdevelopment in a Sox10-NGFP mutant mouse, The 6th Asian Biophysics Association Symposium and the 27th Hong Kong Society of Neuroscience Annual Meeting, Hong Kong, 11 - 15 January 2009.

Researcher : Sham PC

List of Research Outputs

Li M., Cheng T.S., Ho W.L., Chan K.H., Mak W., Cheung R.T.F., Ramsden D.B., Sham P.C., Song Y. and Ho S.L., –459C>T point mutation in 5' non-coding region of human GJB1 gene is linked to X-linked Charcot-Marie-Tooth neuropathy. , Journal of the Peripheral Nervous System. J Peripher Nerv Syst, 2009, 14: 14-21.

Researcher : Shea GKH

List of Research Outputs

Shea G.K.H., Tsui Y.P., Chan Y.S. and Shum D.K.Y., Ex Vivo Generation of Myelinating Schwann-cell Like Cells from Bone Marrow-derived Neurospheres, 13th Research Postgraduate Symposium, Hong Kong, December 10 & 11. 2008.

Shea G.K.H., Tsui Y.P., Chan Y.S. and Shum D.K.Y., Ex vivo generation of myelinating Schwann-cell-like cells from bone marrow-derived neurospheres, Proc. 6th Asian Biophysics Association Symposium. 2009, 68-69.

Shea G.K.H., Tsui Y.P., Chan Y.S. and Shum D.K.Y., Ex vivo generation of myelinating Schwann-cell-like cells from bone marrow-derived neurospheres, Soc. Neurosci. Abst. (USA), 623.3/B30. 2008.

Tsui Y.P., Shea G.K.H., Ao Q., Chan Y.S. and Shum D.K.Y., Schwann cells derived from bone marrow stromal cells – in vitro study with dorsal root ganglia and in vivo study with peripheral nerve conduits. Neuroscience Research (Suppl 1): S, [31st Annual Meeting of Japan Neuroscience Society Tokyo. July 9-11, 2008 . 2008.

Researcher : Shum DKY

List of Research Outputs

Ao Q., Fung C.K., Tsui Y.P., Chan Y.S. and Shum D.K.Y., Chitosan nerve conduits seeded with bone marrow stromal cell-derived Schwann cells enhance regeneration of transected sciatic nerves of adult rats, Abstracts of 4th Int’l Symp. on Healthy Aging: Emerging Therapy for an Aging Population: 69. 2009.

Cham W.C., Ma C.W., Zhang Y., Xie H., Yung W.H., Chan Y.S. and Shum D.K.Y., Heparanase modulates synaptic plasticity at the hippocampus, Abstracts of 4th Int’l Symp. on Healthy Aging: Emerging Therapy for an Aging Population: 77. 2009.

Cham W.C., Ma C.W., Zhang Y., Chan Y.S. and Shum D.K.Y., Role of heparanase in synaptic plasticity at the hippocampus and the vestibular nucleus, Proc. 6th Asian Biophysics Association Symposium. 2009, 167-168.

Chan C.H., Leung O.Y.V., Ip M.S.M. and Shum D.K.Y., HS/syndecan modulate proteolytic balance in airway inflammation, American Society for Matrix Biology, 2008 Meeting, San Diego, California, USA. December 07-10. 2008.

Chan C.H., Leung O.Y.V., Ip M.S.M. and Shum D.K.Y., Shed Syndecan-1 Restricts Neutrophil Elastase from alpha-1-Antitrypsin in Neutrophilic Airway Inflammation, American Journal of Respiratory Cell and Molecular Biology. 2009, 41: 620-628.

Chan K.H., Chan C.H., Ho S.P., Yeung S.C., Shum D.K.Y., Ip M.S.M., Man R.Y.K. and Mak J.C.W., Chinese green tea protects cigarette smoke-induced up-regulation of neutrophil elastase in rat lung, Am J Respir Crit Care Med. 2009, 179: A2022.

Chan K.H., Chan C.H., Ho S.P., Yeung S.C., Shum D.K.Y., Ip M.S.M., Man R.Y.K. and Mak J.C.W., Protection of cigarette smoke-induced up-regulation of neutrophil elastase by Chinese green tea in rat lung, 14th Medical Research Conference, Department of Medicine, HKU. Hong Kong Medical Journal. 2009, 15 (Supp 1): 8.

Chan Y.S., Chen L., Yung K.K.L. and Shum D.K.Y., Molecular and cellular aspects of plasticity after neural injury, Journal of Medical Sciences. 2008, 1(2): 73-79.

Chen L., Yung K.K.L., Chan Y.S., Shum D.K.Y. and Bolam J.P., The proNGF-p75NTR-sortilin signalling complex as new target for the therapeutic treatment of Parkinson’s disease, CNS & Neurological Disorders - Drug Targets. 2008, 7: 512-523.

Fung C.K., Ao Q., Tsui Y.P., Shum D.K.Y. and Chan Y.S., Derivation of Schwann cells from mammalian skin and bone marrow for use in axonal regeneration, Soc. Neurosci. Abst. (USA), 327.13/C22. 2008.

Fung C.K., Ao Q., Tsui Y.P., Shum D.K.Y. and Chan Y.S., In vitro generation of Schwann cells from mammalian skin for bridging injured nerves, Proc. 6th Asian Biophysics Association Symposium. 2009, 161-162.

Lai C.H., Ng K.Y., Yung K.K.L., Shum D.K.Y. and Chan Y.S., Co-expression of GABA_BR1and GABA_BR2 receptor subunits in rat vestibular nucleus, Neuroembryology and Aging. 2008, 5: 127-133.

Lai C.H., Ng K.Y., Yung K.K.L., Shum D.K.Y. and Chan Y.S., Coexpression of GABABR1 and GABABR2 Receptor Subunits in the Rat Vestibular Nucleus , Neuroembryology and Aging . 2008, 5: 127-133.

Lai S.K., Lai C.H., Tse Y.C., Yung K.K.L., Shum D.K.Y. and Chan Y.S., Developmental maturation of ionotropic glutamate receptor subunits in rat vestibular nuclear neurons responsive to vertical linear acceleration, European Journal of Neuroscience. 2008, 11: 2157-2172.

Lai S.K., Lai C.H., Zhang F.X., Ma C.W., Shum D.K.Y. and Chan Y.S., Neural plasticity of otolith-related vestibular system, Acta Academiae Medicinae Sinicae. 2008, 30: 741-746.

Leung O.Y.V., Chan C.H., Ip M.S.M. and Shum D.K.Y., The Potential Use of Heparinase-generated Heparin Fragments in the Treatment of Bronchiectasis and Chronic Obstructive Pulmonary Disease, 13th Research Postgraduate Symposium, Hong Kong December 10 & 11. 2008.

Li M., Chan Y.S. and Shum D.K.Y., The Role of Chondroitin Sulfate Moieties on Cranial Motor Neuron Migration in the Developing Hindbrain of Rates, 13th Research Postgraduate Symposium, HKU. Hong Kong December 10 & 11. 2008.

Li M., Chan Y.S. and Shum D.K.Y., The expression of chondroitin sulfates in rat embryonic hindbrain and their roles on the lateral migration of trigeminal motor neurons, Proc. 6th Asian Biophysics Association Symposium. 2009, 143-144.

Li M., Chan Y.S. and Shum D.K.Y., The restrictive role of chondroitin sulfate moieties on the lateral migration of trigeminal motor neurons during hindbrain development in rats, Soc. Neuroscience Abstract (USA), 29.14/C57. [Washington DC. Nov. 15-19, 2008]. 2008.

Li M., Chan Y.S. and Shum D.K.Y., The role of chondroitin sulfate moieties on trigeminal motor neuron migration in embryonic rat hindbrain, Abstracts of 4th Int’l Symp. on Healthy Aging: Emerging Therapy for an Aging Population: 80. 2009.

Ma C.W., Lai C.H., Shum D.K.Y. and Chan Y.S., Carbohydrate and core protein components of perineuronal net play differential roles in functional modifications of vestibular nuclear neurons in the rat, Abstracts of Physiology Symposium 2009: 38. Hong Kong, May 29-30. 2009.

Ma C.W., Lai C.H., Shum D.K.Y. and Chan Y.S., Changes in perineuronal net components correlate with functional modifications of vestibular nuclear neurons in rats, Soc. Neuroscience Abstract (U.S.A.). 2008, 169.6.

Ma C.W., Lai C.H., Shum D.K.Y. and Chan Y.S., Differential involvement of perineuronal net components in functional modifications of vestibular nuclear neurons in the rat, Proc. 6th Asian Biophysics Association Symposium. 2009, 72.

Ma C.W., Lai C.H., Shum D.K.Y. and Chan Y.S., Differential roles of perineuronal net components in functional modifications of rat vestibular nuclear neurons, Abstracts of Fourth International Symposium on Healthy Aging: Emerging Therapy for an Aging Population: 76 . 2009.

Ma C.W., Lai C.H., Shum D.K.Y. and Chan Y.S., Overexpression of Hoxb3 affects inner ear neurogenesis, Proc. 6th Asian Biophysics Association Symposium, p. 72. 2009.

Ng K.P., Lai C.H., Shum D.K.Y. and Chan Y.S., Maturation profile of thalamic neurons responsive to rotational and translational motions, Soc. Neuroscience Abstract (U.S.A.). 2008, 169.13.

Shea G.K.H., Tsui Y.P., Chan Y.S. and Shum D.K.Y., Ex Vivo Generation of Myelinating Schwann-cell Like Cells from Bone Marrow-derived Neurospheres, 13th Research Postgraduate Symposium, Hong Kong, December 10 & 11. 2008.

Shea G.K.H., Tsui Y.P., Chan Y.S. and Shum D.K.Y., Ex vivo generation of myelinating Schwann-cell-like cells from bone marrow-derived neurospheres, Proc. 6th Asian Biophysics Association Symposium. 2009, 68-69.

Shea G.K.H., Tsui Y.P., Chan Y.S. and Shum D.K.Y., Ex vivo generation of myelinating Schwann-cell-like cells from bone marrow-derived neurospheres, Soc. Neurosci. Abst. (USA), 623.3/B30. 2008.

Sun X., Guo Y.P., Shum D.K.Y., Chan Y.S. and He J., Time course of cortically induced Fos expression in auditory thalamus and midbrain after bilateral cochlear ablation, Neuroscience. 2009, 60: 186-197.

Tam K.W., Li R.A., Chan Y.S. and Shum D.K.Y., Chondroitinase ABC isoforms cooperate to enhance axonal growth, Proc. 6th Asian Biophysics Association Symposium. 2009, 163-164.

Tam K.W., Li R.A., Chan Y.S. and Shum D.K.Y., Use of chondroitin sulphate exolyase and endolyase to decrease axon-restrictive chondroitin sulphates in neural environments, Soc. Neuroscience Abstract (U.S.A.), 651.2/AA19. 2008.

Tsui Y.P., Shea G.K.H., Ao Q., Chan Y.S. and Shum D.K.Y., Schwann cells derived from bone marrow stromal cells – in vitro study with dorsal root ganglia and in vivo study with peripheral nerve conduits. Neuroscience Research (Suppl 1): S, [31st Annual Meeting of Japan Neuroscience Society Tokyo. July 9-11, 2008 . 2008.

Yeung M.N., Zhou Z., Chan D. and Shum D.K.Y., A Novel Non-invasive Role of Heparanase: Promotion of Cartilage Matrix Mineralization, 13th Research Postgraduate Symposium, HKU. December 10 & 11, 2008, Hong Kong. 2008.

Researcher : Shum KT

List of Research Outputs

Lin Y., Shum K.T., Tanner J.A. and Zheng B., In vitro selection of DNA aptamers binding H5N1 Virus nucleoprotein, HKU 13th Research Postgraduate Symposium. 2008.

Shum K.T. and Tanner J.A., Aptamer-mediated Inhibition of Mycobacterium tuberculosis Polyphosphate Kinase 2, Hong Kong Chemical Biology Symposium 2009 . 2009.

Shum K.T. and Tanner J.A., Differential inhibition of the SARS coronavirus helicase by distinct structural classes of DNA aptamers, Chembiochem. 2008, 9: 3037-3045.

Shum K.T. and Tanner J.A., Targeting the Polyphosphate Kinase 2 with Aptamer-based Inhibitors as an Approach to Tuberculosis Therapy, 13th Research Postgraduate Symposium, HKU, Hong Kong, December 10 & 11. 2008.

Researcher : Shum KT

List of Research Outputs

Lin Y., Shum K.T., Tanner J.A. and Zheng B., In vitro selection of DNA aptamers binding H5N1 Virus nucleoprotein, HKU 13th Research Postgraduate Symposium. 2008.

Shum K.T. and Tanner J.A., Aptamer-mediated Inhibition of Mycobacterium tuberculosis Polyphosphate Kinase 2, Hong Kong Chemical Biology Symposium 2009 . 2009.

Shum K.T. and Tanner J.A., Differential inhibition of the SARS coronavirus helicase by distinct structural classes of DNA aptamers, Chembiochem. 2008, 9: 3037-3045.

Researcher : Siu KL

List of Research Outputs

Choy Y.W.E., Siu K.L., Kok K.H., Lung R.W.M., Tsang C.M., To K.F., Kwong D.L.W., Tsao G.S.W. and Jin D., An Epstein-Barr virus-encoded microRNA targets PUMA to promote host cell survival, Journal of Experimental Medicine. 2008, 205: 2551-2560.

Ng M.H., Siu K.L., Ching Y.P. and Jin D., Roles and Regulation of MIPT3 in Interferon Signaling, 13th Research Postgraduate Symposium, HKU. Hong Kong December 10 & 11. 2008.

Siu K.L., Kok K.H., Ng M.H., Poon K.M., Yuen K.Y., Zheng B. and Jin D., Severe acute respiratory syndrome coronavirus M protein inhibits type I interferon production by impeding the formation of TRAF3.TANK.TBK1/IKKepsilon complex., Journal of Biological Chemistry. 2009, 284: 16202-16209.

Tang H.M.V., Siu K.L., Wong C.M. and Jin D., Loss of Yeast Peroxiredoxin TSAI Induces Genome Instability Through Constitutive Activation of DNA Damage Checkpoint and Elevation of Cellular dNTP Levels, 13th Research Postgraduate Symposium, HKU. Hong Kong December 10 & 11. 2008.

Tang H.M.V., Siu K.L., Wong C.M. and Jin D., Loss of peroxiredoxin Tsa1p induces genome instability through activation of DNA damage checkpoint and elevation of dNTP levels., 3rd American Society for Microbiology Conference on DNA Repair and Mutagenesis. Fairmont Chateau Whistler, Whistler, BC, Canada. 2009.

Researcher : Siu YT

List of Research Outputs

Chan C.P., Siu Y.T. and Jin D., The role of CREB in Ras-induced expression of interleukin 8., 8th EMBL Transcription Meeting, EMBL Heidelberg. 2008.

Siu Y.T., Activation of TORC1 Transcriptional Coactivator through MEKK1-induced Phosphorylation and Ubiquitination, PhD Thesis. 2009.

Siu Y.T., Ching Y.P. and Jin D., Activation of TORC1 transcriptional coactivator through MEKK1-induced phosphorylation, Molecular Biology Of The Cell. 2008, 19: 4750-61.

Siu Y.T. and Jin D., Activation of TORCI transcriptional Coactivator Through MEKKI-induced Phosphorylation and Ubiquitination, 13th Research Postgraduate Symposium, HKU. Hong Kong, December 10 & 11. 2008.

Siu Y.T. and Jin D., MEKK1-induced phosphorylation and activation of TORC1 transcriptional coactivator, 8th EMBL Transcription Meeting, EMBL Heidelberg, Germany. 2008.

Siu Y.T., Society of Chinese Bioscientists in America Travel Fellowship 2009, Society of Chinese Bioscientists in America. 2009.

Researcher : Siu YT

List of Research Outputs

Chan C.P., Siu Y.T. and Jin D., The role of CREB in Ras-induced expression of interleukin 8., 8th EMBL Transcription Meeting, EMBL Heidelberg. 2008.

Siu Y.T., Activation of TORC1 Transcriptional Coactivator through MEKK1-induced Phosphorylation and Ubiquitination, PhD Thesis. 2009.

Siu Y.T., Ching Y.P. and Jin D., Activation of TORC1 transcriptional coactivator through MEKK1-induced phosphorylation, Molecular Biology Of The Cell. 2008, 19: 4750-61.

Siu Y.T. and Jin D., MEKK1-induced phosphorylation and activation of TORC1 transcriptional coactivator, 8th EMBL Transcription Meeting, EMBL Heidelberg, Germany. 2008.

Siu Y.T., Society of Chinese Bioscientists in America Travel Fellowship 2009, Society of Chinese Bioscientists in America. 2009.

Researcher : Smith DK

List of Research Outputs

Cheung C.L., Chan B.Y.Y., Chan V.N.Y., Ikegawa S., Kou I., Ngai H.H.Y., Smith D.K., Luk K.D.K., Huang Q., Mori S., Sham P.C. and Kung A.W.C., Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible genetic association with bone mineral density variation , Human Molecular Genetics. 2009, 18: 679-687.

Chung B.H.Y., Lam S.T.S., Tong T.M.F., Li Y.H., Lun K.S., Chan D.H.C., Fok S.F.S., Or J.S.F., Smith D.K., Yang W. and Lau Y.L., Identification of Noel FBN1 and TGFBR2 Mutations in 65 Probands with Marfan Syndrome or Marfan-Like Phenotypes, American Journal of Medical Genetics. 2009, 149A(7): 1452-1459.

Tang L.F., Cheung C.L., Sham P.C., McClurg P., Lee B.B.C., Chan S.Y., Smith D.K., Tanner J.A., Su A.I., Cheah K.S.E., Kung A.W.C. and Song Y., Genome-wide haplotype association mapping in mice identifies a genetic variant in CER1 associated with bone mineral density and fracture in southern Chinese women., J Bone Miner Res . 2008, 24(6): 1013-21.

Zhou J., Smith D.K., Lu L., Poon K.M., Ng F., Chen D., Huang J., Yuen K.Y. and Zheng B., A non-synonymous single nucleotide polymorphism in IFNAR1 affects susceptibility to chronic hepatitis B virus infection, J Viral Hepat. 2009, 16(1): 45-52.

Researcher : Song Y

List of Research Outputs

Chai L., Song Y., Zee K.Y. and Leung W.K., Single nucleotide polymorphisms of Fc-gamma receptor genes and periodontitis, Journal of Clinical Periodontology. 2009, 36 (Suppl 9): 88.

Chai L., Song Y., Zee K.Y. and Leung W.K., Single nucleotide polymorphisms of complement component 5 and periodontitis, Journal of Clinical Periodontology. 2009, 36 (Suppl 9): 87.

Cheng M.H., Choy R.K.W., Zheng C., Tsang W.H., Tsang S.L., Song Y., Pang C.P. and Sham M.H., A _γA-crystallin Mouse Mutant Secc with Small Eye, Cataract and Closed Eyelid, 13th Research Postgraduate Symposium, HKU December 10 & 11. 2008.

Cheung B.M.Y., Ong K.L., Leung Y.H., Wong L.Y.F., Song Y. and Sham P.C., Single-nucleotide polymorphisms near the microsatellite D17S1303 and the development of hypertension in a 6-year longitudinal study, Journal of Human Hypertension. 2008, 22: 151-153.

Cheung K.M.C., Karppinen J., Chan D., Ho D.W.H., Song Y., Sham P.C., Cheah K.S.E., Leong J.C.Y. and Luk K.D.K., Prevalence and pattern of lumbar MRI changes in a population study of 1043 individuals, Spine. 2009, 34(9): 934-40.

Chu L.W., Tam S., Lee P.W.H., Yik P.Y., Song Y., Cheung B.M.Y. and Lam K.S.L., Late-Life Body Mass Index and Waist Circumference in Amnestic Mild Cognitive Impairment and Alzheimer's Disease, Journal of Alzheimer's Disease. 2009, 17: 223-232.

Ho D.W.H., Cheung K.M.C., Karppinen J., Yip S.P., Ott J., Luk K.D.K., Leong J.C.Y., Cheah K.S.E., Sham P.C. and Song Y., Linkage Analysis With Subsequent Fine-mapping On Familial Early-onset Degenerative Disc Disease, The 10th International Meeting on Human Genome Variation Toronto, Canada http://www.tcag.ca/hgv2008/. 2008.

Lam T.K., Chan D., Cheah K.S.E. and Song Y., In Vivo Study Of Asporin Polymorphic Variants In Chondrogenesis And Degenerative Skeletal Diseases, 13th Research Postgraduate Symposium, Hong Kong December 10 & 11. 2008.

Lam T.K., Chan D., Cheah K.S.E. and Song Y., In vivo Study of Asporin Polymorphic Variants in Chondrogenesis and Degenerative Skeletal Diseases, Matrix Biology Society of Australia and New Zealand (MBSANZ), October 13-16. NSW, Australia, 2008.

Li M., Jiang L., Kao P.Y.P., Sham P.C. and Song Y., IGG3: a tool to rapidly integrate large genotype datasets for whole-genome imputation and individual-level meta-analysis, Bioinformatics. 2009, 25 (11): 1449-1450.

Li M., Sham P.C. and Song Y., KGG: A Systematic Biological Knowledge-based Mining System for Genome-wide Genetic Studies, 13th Research Postgraduate Symposium, HKU. Hong Kong December 10 & 11. 2008.

Li M., Jiang L., Sham P.C. and Song Y., Power of transmission/disequilibrium tests in admixed populations, Genetic Epidemiology. 2008, 32: 434-444.

Li M., Cheng T.S., Ho W.L., Chan K.H., Mak W., Cheung R.T.F., Ramsden D.B., Sham P.C., Song Y. and Ho S.L., –459C>T point mutation in 5' non-coding region of human GJB1 gene is linked to X-linked Charcot-Marie-Tooth neuropathy. , Journal of the Peripheral Nervous System. J Peripher Nerv Syst, 2009, 14: 14-21.

Li Y., Chu L.W., Li Z., Yik P.Y. and Song Y., A study on the association of the chromosome 12p13 locus with sporadic late-onset Alzheimer's disease in Chinese., Dement Geriatr Cogn Disord. Epub, 2009, 27(6): 508-12.

Li Y., Chu L.W. and Song Y., Cholesterol and genetics of Alzheimer¡¦s disease, Alzheimer's Association 2009 International Conference on Alzheimer's Disease (ICAD). 2009.

Li Y., Chu L.W., Cheung B.M.Y., Leung Y.H., Yik P.Y. and Song Y., Genetic Analysis of Alzheimer’s Disease Associated Genes – A Perspective from Abnormal Cholesterol Metabolism . Fourth international symposium on healthy aging, 2009.

Liu J.R., Sun X.R., Dong H.W., Sun C.H., Sun W.G., Chen B.Q., Song Y. and Yang B.F., beta-Ionone suppresses mammary carcinogenesis, proliferative activity and induces apoptosis in the mammary gland of the Sprague-Dawley rat, International journal of cancer. Journal international du cancer. 2008, 122: 2689-2698.

Sham P.C., Cherny S.S., Kao P.Y.P., Song Y., Chan D. and Cheung K.M.C., (iii) Whole-genome association studies of complex diseases, Current Orthopaedics. 2008, 22: 251-258.

So J.C.C., Song Y., Tsang S.T.Y., Tang L.F., Chan A.Y.W., Ma E.S.K. and Chan L.C., The HBS1L-MYB intergenic region on chromosome 6q23 is a quantitative trait locus controlling fetal haemoglobin level in carries of β-thalassaemia, J Med Gen. 2008, 45(11): 745-51.

Song Y., Tang L.F., Wong S.Y.Y., Leung W.L., Sham P.C. and Cheah K.S.E., Genetic Modifier(s) Of Embryonic Lethality In Type Iia Procollagen Deficient Mice , 58th Annual Meeting of The American Society of Human Genetics http://www.ashg.org/2008meeting/ Philadelphia, USA. Nov 11-15. 2008.

Tang L.F., Cheung C.L., Sham P.C., McClurg P., Lee B.B.C., Chan S.Y., Smith D.K., Tanner J.A., Su A.I., Cheah K.S.E., Kung A.W.C. and Song Y., Genome-wide haplotype association mapping in mice identifies a genetic variant in CER1 associated with bone mineral density and fracture in southern Chinese women., J Bone Miner Res . 2008, 24(6): 1013-21.

Tang L.F. and Song Y., Lab2: a Web platform for mouse geneticists, Best Poster, Pacific Symposium on Biocomputing Big Island of Hawaii. 2009.

Tang L.F., Cheah K.S.E., Sham P.C. and Song Y., Mapping a genetic modifier for heart defects in Type IIA procollagen deficient mutant mice, Best Poster, New Developments in Quantitative Molecular Bioscience, Greece, 10-17 September, 2008. 2008.

Tang L.F., Cheah K.S.E. and Song Y., Mapping a genetic modifier for heart defects in Type IIA procollagen deficient mutant mice, New Developments in Quantitative Molecular Bioscience. Island of Spetses, Greece, 2008.

Zhang Y. and Song Y., The Role of Pax6 in Beta-Amyloid Induced Neuronal Death, 13th Research Postgraduate Symposium, December 10 & 11, 2008. HKU. 2008.

Researcher : Szeto YY

List of Research Outputs

Au Y.K., Wynn S...L., Szeto Y.Y., Geng G...Y...H., Cheung K.M.C. and Cheah K.S.E., Mutant Sox9 exerts context dependent gain-of-function impact in a campomelic dysplasia mouse model, Gordon Research Conferences - 2009 Program (Cartilage Biology & Pathology). Les Diablerets Conference Center, Les Diablerets, Switzerland June 7-12,. 2009.

Cheah K.S.E., Au Y.K., Szeto Y.Y., Wynn S.L., Geng G.Y.H., Chan Y.S., Chan W.Y., Cheung K.M.C. and Fritzsch B., Illuminating the aetiology of Campomelic dysplasia caused by mutation in the transactivation domain of SOX9, Frontiers in Biomedical Research, Hong Kong December 12. 2008.

Cheah K.S.E., Au Y.K., Szeto Y.Y., Wynn S.L., Chan Y.S., Cheung K.M.C., Chan W.Y., Lovell-Badge R.H. and Fritzsch B., Insights into the function of SOX9 and campomelic dysplasia, American Society for Matrix Biology, 2008 Meeting, San Diego, California, USA, December 07-10. 2008.

Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Sox10 mutation affects inner ear gliogenesis and morphogenesis, The 7th Molecular Biology of Hearing and Deafness. Harvard Medical School. Boston, June 20-23, USA. 2009.

Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Cheah K.S.E. and Sham M.H., The Role of Sox 10 in Mouse Inner Ear Development, 13th Research Postgraduate Symposium, HKU December 10 & 11. 2008.

Mak C.Y.A., Szeto Y.Y. and Cheah K.S.E., Differential and Overlapping Expression of SOX2 and SOX9 in Inner Ear Development, 13th Research Postgraduate Symposium, HKU. Hong Kong December 10 & 11. 2008.

Mak C.Y.A., Szeto Y.Y., Fritzsch B. and Cheah K.S.E., Differential and Overlapping Expression of SOX2 and SOX9 in Inner Ear Development, Common Themes and New Concerpts in Sensory Formation April13-15 2009 Kobe, Japan. 2008.

Szeto Y.Y., Au Y.K., Wynn S., Chan Y.S., Lovell-Badge R., Chan W.Y., Fritzsch B. and Cheah K.S.E., Sensorineural Deafness in a mouse model of Campomelic Dysplasia, The 18th CDB Meeting, Common themes and New Concepts in Sensory Formation, RIKEN Center for Developmental Biology, April 13-16, Kobe, Japan . 2009.

Szeto Y.Y., Leung K.K.H., Sham M.H. and Cheah K.S.E., Utility of Hoxb2 Enhancer-mediated Cre Activity for Functional Studies in the Developing Inner ear, Common Themes and New Concepts in Sensory Formation, April 13-15 2009, Kobe, Japan . 2008.

Szeto Y.Y., Leung K.K.H., Sham M.H. and Cheah K.S.E., Utility of Hoxb2 enhancer - mediated Cre activity for functional studies in the developing inner ear, Genesis. 2009, 47(6): 361-365.

Researcher : Tang HMV

List of Research Outputs

Tang H.M.V., Siu K.L., Wong C.M. and Jin D., Loss of Yeast Peroxiredoxin TSAI Induces Genome Instability Through Constitutive Activation of DNA Damage Checkpoint and Elevation of Cellular dNTP Levels, 13th Research Postgraduate Symposium, HKU. Hong Kong December 10 & 11. 2008.

Tang H.M.V., Siu K.L., Wong C.M. and Jin D., Loss of peroxiredoxin Tsa1p induces genome instability through activation of DNA damage checkpoint and elevation of dNTP levels., 3rd American Society for Microbiology Conference on DNA Repair and Mutagenesis. Fairmont Chateau Whistler, Whistler, BC, Canada. 2009.

Tang H.M.V., Society of Chinese Bioscientists in America Travel Fellowship 2009, Society of Chinese Bioscientists in America. 2009.

Researcher : Tang LF

List of Research Outputs

So J.C.C., Song Y., Tsang S.T.Y., Tang L.F., Chan A.Y.W., Ma E.S.K. and Chan L.C., The HBS1L-MYB intergenic region on chromosome 6q23 is a quantitative trait locus controlling fetal haemoglobin level in carries of β-thalassaemia, J Med Gen. 2008, 45(11): 745-51.

Song Y., Tang L.F., Wong S.Y.Y., Leung W.L., Sham P.C. and Cheah K.S.E., Genetic Modifier(s) Of Embryonic Lethality In Type Iia Procollagen Deficient Mice , 58th Annual Meeting of The American Society of Human Genetics http://www.ashg.org/2008meeting/ Philadelphia, USA. Nov 11-15. 2008.

Tang L.F., Cheung C.L., Sham P.C., McClurg P., Lee B.B.C., Chan S.Y., Smith D.K., Tanner J.A., Su A.I., Cheah K.S.E., Kung A.W.C. and Song Y., Genome-wide haplotype association mapping in mice identifies a genetic variant in CER1 associated with bone mineral density and fracture in southern Chinese women., J Bone Miner Res . 2008, 24(6): 1013-21.

Tang L.F. and Song Y., Lab2: a Web platform for mouse geneticists, Best Poster, Pacific Symposium on Biocomputing Big Island of Hawaii. 2009.

Tang L.F., Cheah K.S.E., Sham P.C. and Song Y., Mapping a genetic modifier for heart defects in Type IIA procollagen deficient mutant mice, Best Poster, New Developments in Quantitative Molecular Bioscience, Greece, 10-17 September, 2008. 2008.

Tang L.F., Cheah K.S.E. and Song Y., Mapping a genetic modifier for heart defects in Type IIA procollagen deficient mutant mice, New Developments in Quantitative Molecular Bioscience. Island of Spetses, Greece, 2008.

Researcher : Tang LF

List of Research Outputs

Tang L.F. and Song Y., Lab2: a Web platform for mouse geneticists, Best Poster, Pacific Symposium on Biocomputing Big Island of Hawaii. 2009.

Researcher : Tanner JA

List of Research Outputs

Chan W.L., Chan D., Lee S., Cheah K.S.E. and Tanner J.A., Differential protein profiling of stressed chondrocytes and skeletal dysplasia disease, Human Proteomics Organisation (HUPO) Annual Meeting August 16-20, 2008, Amsterdam, Netherlands. 2008.

Cheah K.S.E., Chan C.C.Y., Choi M.Y., Tanner J.A., Luk K.D.K. and Chan D., Essential and dose-dependent requirement for the sedlin component of the trapp complex in development, Cold Spring Harbor Meeting on Mouse Genetics & Genomics: Development & Disease, Cold Sping Harbor, New York, USA, October 29 - November 2, 2008.

Kimura M. and Tanner J.A., Delivery of SCV Helicase Aptamers Using Cationic Lipidic Systems, 13th Research Postgraduate Symposium, HKU. Hong Kong. December 10 & 11. 2008.

Lin Y., Shum K.T., Tanner J.A. and Zheng B., In vitro selection of DNA aptamers binding H5N1 Virus nucleoprotein, HKU 13th Research Postgraduate Symposium. 2008.

Miller A.D. and Tanner J.A., Essentials Of Chemical Biology: Structure and Dynamics of Biological Macromolecules. Wiley, UK, 2008, 573 pages.

Shum K.T. and Tanner J.A., Aptamer-mediated Inhibition of Mycobacterium tuberculosis Polyphosphate Kinase 2, Hong Kong Chemical Biology Symposium 2009 . 2009.

Shum K.T. and Tanner J.A., Differential inhibition of the SARS coronavirus helicase by distinct structural classes of DNA aptamers, Chembiochem. 2008, 9: 3037-3045.

Shum K.T. and Tanner J.A., Targeting the Polyphosphate Kinase 2 with Aptamer-based Inhibitors as an Approach to Tuberculosis Therapy, 13th Research Postgraduate Symposium, HKU, Hong Kong, December 10 & 11. 2008.

Tang L.F., Cheung C.L., Sham P.C., McClurg P., Lee B.B.C., Chan S.Y., Smith D.K., Tanner J.A., Su A.I., Cheah K.S.E., Kung A.W.C. and Song Y., Genome-wide haplotype association mapping in mice identifies a genetic variant in CER1 associated with bone mineral density and fracture in southern Chinese women., J Bone Miner Res . 2008, 24(6): 1013-21.

Tanner J.A., Nucleic acid aptamers – tools for chemical biology, Hong Kong Chemical Biology Symposium 2009.

Researcher : Tsang KY

List of Research Outputs

Chan W.C.W., Tsang K.Y., Cheng Y.W., Chik H.Y.H., Melhado I.G., Boyde A., Jones S., Cheah K.S.E. and Chan D., Activating ER-stress in differentiating osteocytes impairs maturation causing hyperostosis in mice, XXI Meeting of the Federation of the European Connective Tissue Societies, Marseille, France 9-13 July 2008.

Wang C., Tsang K.Y., Chan D. and Cheah K.S.E., Best Poster: the Roles Of Chop And Gadd34 In The Adaptation Of Hypertrophic Chondrocytes To Er Stress , , Gordon Conference (cartilage Biology & Pathology). 2009.

Wang C., Tsang K.Y., Chan D. and Cheah K.S.E., The Roles of CHOP and GADD34 in the Adaptation of Hypertrophic Chondrocytes to ER Stress, Gordon Research Conferences - 2009 Program (Cartilage Biology & Pathology). Les Diablerets Conference Center, Les Diablerets, Switzerland June 7-12. 2009.

Researcher : Tsang SL

List of Research Outputs

Cheng M.H., Choy R.K.W., Zheng C., Tsang W.H., Tsang S.L., Song Y., Pang C.P. and Sham M.H., A _γA-crystallin Mouse Mutant Secc with Small Eye, Cataract and Closed Eyelid, 13th Research Postgraduate Symposium, HKU December 10 & 11. 2008.

Researcher : Tsang SW

List of Research Outputs

Thomas M.K., Tsang S.W., Yeung M.L., Leung P.S. and Yao K.M., The roles of the PDZ-containing proteins Bridge-1 and PDZD2 in the regulation of insulin production and pancreatic beta-cell mass, Curr Protein Pept Sci. 2009, 10: 30-36.

Researcher : Tsui YP

List of Research Outputs

Ao Q., Fung C.K., Tsui Y.P., Chan Y.S. and Shum D.K.Y., Chitosan nerve conduits seeded with bone marrow stromal cell-derived Schwann cells enhance regeneration of transected sciatic nerves of adult rats, Abstracts of 4th Int’l Symp. on Healthy Aging: Emerging Therapy for an Aging Population: 69. 2009.

Fung C.K., Ao Q., Tsui Y.P., Shum D.K.Y. and Chan Y.S., Derivation of Schwann cells from mammalian skin and bone marrow for use in axonal regeneration, Soc. Neurosci. Abst. (USA), 327.13/C22. 2008.

Fung C.K., Ao Q., Tsui Y.P., Shum D.K.Y. and Chan Y.S., In vitro generation of Schwann cells from mammalian skin for bridging injured nerves, Proc. 6th Asian Biophysics Association Symposium. 2009, 161-162.

Shea G.K.H., Tsui Y.P., Chan Y.S. and Shum D.K.Y., Ex Vivo Generation of Myelinating Schwann-cell Like Cells from Bone Marrow-derived Neurospheres, 13th Research Postgraduate Symposium, Hong Kong, December 10 & 11. 2008.

Shea G.K.H., Tsui Y.P., Chan Y.S. and Shum D.K.Y., Ex vivo generation of myelinating Schwann-cell-like cells from bone marrow-derived neurospheres, Proc. 6th Asian Biophysics Association Symposium. 2009, 68-69.

Shea G.K.H., Tsui Y.P., Chan Y.S. and Shum D.K.Y., Ex vivo generation of myelinating Schwann-cell-like cells from bone marrow-derived neurospheres, Soc. Neurosci. Abst. (USA), 623.3/B30. 2008.

Tsui Y.P., Shea G.K.H., Ao Q., Chan Y.S. and Shum D.K.Y., Schwann cells derived from bone marrow stromal cells – in vitro study with dorsal root ganglia and in vivo study with peripheral nerve conduits. Neuroscience Research (Suppl 1): S, [31st Annual Meeting of Japan Neuroscience Society Tokyo. July 9-11, 2008 . 2008.

Tsui Y.P., In vitroderivation of myelinating Schwann cells for use in chitosan-based nerve guidance channels, MPhil Thesis. 2009.

Researcher : Tsui YP

List of Research Outputs

Shea G.K.H., Tsui Y.P., Chan Y.S. and Shum D.K.Y., Ex vivo generation of myelinating Schwann-cell-like cells from bone marrow-derived neurospheres, Soc. Neurosci. Abst. (USA), 623.3/B30. 2008.

Tsui Y.P., In vitroderivation of myelinating Schwann cells for use in chitosan-based nerve guidance channels, MPhil Thesis. 2009.

Researcher : Wang C

List of Research Outputs

Wang C., Tsang K.Y., Chan D. and Cheah K.S.E., Best Poster: the Roles Of Chop And Gadd34 In The Adaptation Of Hypertrophic Chondrocytes To Er Stress , , Gordon Conference (cartilage Biology & Pathology). 2009.

Wang C., Tsang K.Y., Chan D. and Cheah K.S.E., The Roles of CHOP and GADD34 in the Adaptation of Hypertrophic Chondrocytes to ER Stress, Gordon Research Conferences - 2009 Program (Cartilage Biology & Pathology). Les Diablerets Conference Center, Les Diablerets, Switzerland June 7-12. 2009.

Researcher : Wang JJ

List of Research Outputs

Wang J.J., Computational methods for prediction of alternative promoters and transcription factor binding sites., School of Computing, National University of Singapore, Singapore. 10 November, 2008. 2008.

Wang J.J., Computational methods for prediction of promoters and transcription factor binding sites, Institute of Biochemistry and Cell Biology, Shanghai, 14 May, 2009.. 2009.

Wang J.J., Ungar L.H., Tseng H. and Hannenhalli S., MetaProm: a neural network based meta-predictor for alternative human promoter prediction, 16th Annual International Conference Intelligent Systems for Meolecular Biology Meeting, Toronto, Canada July 19-23. 2008.

Wang J.J., Ungar L...H., Tseng H. and Hannenhalli S., MetaProm: a neural network based meta-predictor for alternative human promoter prediction, 16th Annual International Conference Intelligent Systems for Molecular Biology Meeting. Toronto, Canada, July 19-23, 2008.

Wang J.J., PC Member, IEEE International Conference on Bioinformatics & Biomedicine 2008, 3-5 Nov., 2008, Philadelphia, PA, USA.. 2008.

Wang J.J., Wei F., Zaprazna K. and Atchison M.L., PU.1 can Recruit BCL6 to DNA to Repress Gene Expression in Germinal Center B Cells, Pacific Symposium on Biocomputing Meeting, Big Island, Hawaii, USA. Jan 5-9, 2009.. 2009.

Wei F., Zaprazna K., Wang J.J. and Atchison M.L., PU.1 can Recruit BCL6 to DNA to Repress Gene Expression in Germinal Center B Cells., Mol. Cell. Biol.. 2009, 29: 4612-4622.

Researcher : Wang Z

List of Research Outputs

Cui J., Wang Z., Zeng Q.N., Leung P.S., Yao K.M. and Huang J., Investigation of the Role of Kif5B in Pancreatic β-cells Function, 13th Research Postgraduate Symposium, December 10 & 11, 2008.

Gan H., Zhu G., Wang Z., Chan D., Cheah K.S.E. and Huang J., Study the function of KIF5B in long bone development, 13th Research Postgraduate Symposium, Hong Kong December 10 & 11. 2008.

Researcher : Wang Z

List of Research Outputs

Cui J., Wang Z., Zeng Q.N., Leung P.S., Yao K.M. and Huang J., Investigation of the Role of Kif5B in Pancreatic β-cells Function, 13th Research Postgraduate Symposium, December 10 & 11, 2008.

Gan H., Zhu G., Wang Z., Chan D., Cheah K.S.E. and Huang J., Study the function of KIF5B in long bone development, 13th Research Postgraduate Symposium, Hong Kong December 10 & 11. 2008.

Researcher : Wong CM

List of Research Outputs

Dong J., Nanda J.S., Rahman H., Pruitt M.R., Shin B.S., Wong C.M., Lorsch J.R. and Hinnebusch A.G., Genetic identification of yeast 18S rRNA residues required for efficient recruitment of initiator tRNA(Met) and AUG selection., Genes and Development. 2008, 22: 2242.

Tang H.M.V., Siu K.L., Wong C.M. and Jin D., Loss of Yeast Peroxiredoxin TSAI Induces Genome Instability Through Constitutive Activation of DNA Damage Checkpoint and Elevation of Cellular dNTP Levels, 13th Research Postgraduate Symposium, HKU. Hong Kong December 10 & 11. 2008.

Tang H.M.V., Siu K.L., Wong C.M. and Jin D., Loss of peroxiredoxin Tsa1p induces genome instability through activation of DNA damage checkpoint and elevation of dNTP levels., 3rd American Society for Microbiology Conference on DNA Repair and Mutagenesis. Fairmont Chateau Whistler, Whistler, BC, Canada. 2009.

Researcher : Wong EYM

List of Research Outputs

Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Sox10 mutation affects inner ear gliogenesis and morphogenesis, The 7th Molecular Biology of Hearing and Deafness. Harvard Medical School. Boston, June 20-23, USA. 2009.

Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Cheah K.S.E. and Sham M.H., The Role of Sox 10 in Mouse Inner Ear Development, 13th Research Postgraduate Symposium, HKU December 10 & 11. 2008.

Sham M.H., Zhang M., Chu K.H., Wong E.Y.M., Chee D.M.C., Cheung M.C.H., Lui V.C.H. and Tam P.K.H., A Novel Sox10-NGFP mouse model of waardenburg_Hirschsprung Syndrome, Neurogastroenterol. 2009, 21(2): XXI.

Sham M.H., Zhang M., Chu K.H., Wong E.Y.M., Chee D.M.C., Cheung M.C.H., Lui V.C.H. and Tam P.K.H., A novel Sox10-NGFP mouse model of Waardenburg-Hirschsprung Syndrome, The 2nd International Symposium on the Development of the Enteric Nervous System, London, U.K.. 2009.

Wong E.Y.M., Fritzsch B., Wu D.K., Chan Y.S., Cheah K.S.E. and Sham M.H., Over-expression of Hoxb3 affects inner ear neurogenesis, The 27th Hong Kong Society of Neuroscience Annual Meeting, Hong Kong. 2008.

Wong E.Y.M., Chan Y.S., Cheah K.S.E. and Sham M.H., Over-expression of Hoxb3 affects sensory neuron differentiation and inner ear morphogenesis., 32nd Annual Midwinter Research Meeting, Association for Research in Otolaryngology, USA. . 2009.

Wong E.Y.M., Postdoctoral Fellow Travel Award was presented by the panel of adjudications at the 2009 MidWinter Meeting , Association for Research in Otolaryngology ARO, USA. 2009.

Wong E.Y.M., The role of Hox genes in craniofacial and inner ear development. , National institute of Health (NIH) - National Institute on Deafness and other Communication Disorders (NIDCD), USA. 8th July, 2008. 2008.

Wong E.Y.M., The role of Hox genes in dorsoventral patterning and morphogenesis. , Gordon Research Conference on Auditory System session “Cochlea development and regeneration” in Colby-Sawyer College, New Hampshire, USA. 1st July, 2008. 2008.

Wong E.Y.M., Travel award was presented by Gordon Research Conference Auditory System 2008, Gordon Research Conference organization. 2008.

Researcher : Wong NS

List of Research Outputs

Lam D. and Wong N.S., An Investigation of the Mutual Relationship between ER Stress and Oxidative Stress, 13th Research Postgraduate Symposium, HKU December 10 & 11. 2008.

Researcher : Wong SYY

List of Research Outputs

Gao Y., Leung W.L., Wong S.Y.Y., Chan D. and Cheah K.S.E., Type IIA Procollagen: A Regulator of Nodal Signaling, 13th Research Postgraduate Symposium, HKU December 10 & 11. 2008.

Song Y., Tang L.F., Wong S.Y.Y., Leung W.L., Sham P.C. and Cheah K.S.E., Genetic Modifier(s) Of Embryonic Lethality In Type Iia Procollagen Deficient Mice , 58th Annual Meeting of The American Society of Human Genetics http://www.ashg.org/2008meeting/ Philadelphia, USA. Nov 11-15. 2008.

Researcher : Wu X

List of Research Outputs

Wu X., Kong C.T. and Zhou Z., Functional Analysis of the Mouse Isthmin Gene Encoding a Novel Secreted Protein, 13th Research Postgraduate Symposium, HKU. Hong Kong. December 10 & 11. 2008.

Researcher : Yang L

List of Research Outputs

Yang L., Genetic analyses of terminal differentiation of hypertrophic chondrocytes, PhD Thesis. 2009.

Researcher : Yao KM

List of Research Outputs

Chan D.W., Liu V.W.S., Tsao G.S.W., Yao K.M., Furukawa T., Chan K.K.L. and Ngan H.Y.S., Loss of MKP3 mediated by oxidative stress enhances tumorigenicity and chemoresistance of ovarian cancer cells , Carcinogenesis. 2008, 29(9): 1742-1750.

Chan D.W., Yu Y.M., Chiu P.M., Yao K.M., Liu V.W.S., Cheung A.N.Y. and Ngan H.Y.S., Over-expression of FOXM1 transcription factor is associated with cervical cancer progression and pathogenesis, Journal of Pathology. 2008, 215 (3): 245-252.

Cui J., Wang Z., Zeng Q.N., Leung P.S., Yao K.M. and Huang J., Investigation of the Role of Kif5B in Pancreatic β-cells Function, 13th Research Postgraduate Symposium, December 10 & 11, 2008.

Leung K.K., Suen P.M., Lau T.K., Ko W.H., Yao K.M. and Leung P.S., PDZ-Domain Containing-2 (PDZD2) Drives the Maturity of Human Fetal Pancreatic Progenitor-Derived Islet-Like Cell Clusters with Functional Responsiveness against Membrane Depolarization, Stem Cells Dev.. 2008, 18: 979-990.

Pang B., Yao K.M. and Shiu S.Y.W., Potential signaling mechanisms of the secreted PDZ domain-containing protein 2 (sPDZD2) in tumor suppression, Annals of Oncology, Vol 20, Suppl. 3. 2009, 20: p29.

Tam C.W., Chan K.W., Liu V.W.S., Pang B., Yao K.M. and Shiu S.Y.W., Melatonin as a negative mitogenic hormonal regulator of human prostate epithelial cell growth: potential mechanisms and clinical significance, Journal of Pineal Research. 2008, 45: 403-412.

Tam C.W., Yao K.M. and Shiu S.Y.W., Putative cellular receptor for secreted PDZ domain-containing protein 2 (sPDZD2) in cancer cells, Physiology Symposium 2009: Physiology from protein structure to function, Department of Physiology, The University of Hong Kong, May 29-30. Hong Kong, 2009, p17.

Tam C.W., Liu V.W.S., Leung W.Y., Yao K.M. and Shiu S.Y.W., The autocrine human secreted PDZ domain-containing protein 2 (sPDZD2) induces senescence or quiescence of prostate, breast and liver cancer cells via transcriptional activation of p53, Cancer Letters. 2008, 271: 64-80.

Thomas M.K., Tsang S.W., Yeung M.L., Leung P.S. and Yao K.M., The roles of the PDZ-containing proteins Bridge-1 and PDZD2 in the regulation of insulin production and pancreatic beta-cell mass, Curr Protein Pept Sci. 2009, 10: 30-36.

Yao K.M., Increased basal insulin secretion in Pdzd2-deficient mice, Asia Islet Biology & Incretin Symposium (AIBIS) 2008 at Incheon, Korea. 2008.

Researcher : Yeung MN

List of Research Outputs

Yeung M.N., Zhou Z., Chan D. and Shum D.K.Y., A Novel Non-invasive Role of Heparanase: Promotion of Cartilage Matrix Mineralization, 13th Research Postgraduate Symposium, HKU. December 10 & 11, 2008, Hong Kong. 2008.

Researcher : Yu B

List of Research Outputs

Yu B., Yuen K.Y., Zheng B. and Huang J., Development of Salmonella-mediated Oral Vaccine against Avian Influenza Viruses H5N1, 13th Research Postgraduate Symposium, HKU. Hong Kong December 10 & 11. 2008.

Researcher : Zhang L

List of Research Outputs

Zhang L. and Zhou Z., Prelamin A Induces Cellular Senescence by Activating Heterochromatin Formation, 13th Research Postgraduate Symposium, HKU. Hong Kong December 10 & 11. 2008.

Zhang L., Prelamin A Induces Premature Senescence and Accelerated Aging by Activating Heterochromatin Formation., Keystone Symposia conference “Chromatin Dynamics and Higher Order Organization” USA. March. 2009.

Researcher : Zhang M

List of Research Outputs

Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Sox10 mutation affects inner ear gliogenesis and morphogenesis, The 7th Molecular Biology of Hearing and Deafness. Harvard Medical School. Boston, June 20-23, USA. 2009.

Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Cheah K.S.E. and Sham M.H., The Role of Sox 10 in Mouse Inner Ear Development, 13th Research Postgraduate Symposium, HKU December 10 & 11. 2008.

Sham M.H., Zhang M., Chu K.H., Wong E.Y.M., Chee D.M.C., Cheung M.C.H., Lui V.C.H. and Tam P.K.H., A Novel Sox10-NGFP mouse model of waardenburg_Hirschsprung Syndrome, Neurogastroenterol. 2009, 21(2): XXI.

Sham M.H., Zhang M., Chu K.H., Wong E.Y.M., Chee D.M.C., Cheung M.C.H., Lui V.C.H. and Tam P.K.H., A novel Sox10-NGFP mouse model of Waardenburg-Hirschsprung Syndrome, The 2nd International Symposium on the Development of the Enteric Nervous System, London, U.K.. 2009.

Zhang M., Leung C., Lui V.C.H., Tam P.K.H. and Sham M.H., Abnormal enteric nervous system development in a Sox10^NGFPmouse mutant, Neurogastroenterol. 2009, 21(2): XVIII.

Zhang M., Leung C., Lui V.C.H., Tam P.K.H. and Sham M.H., Abnormal enteric nervous systemdevelopment in a Sox10-NGFP mutant mouse, The 6th Asian Biophysics Association Symposium and the 27th Hong Kong Society of Neuroscience Annual Meeting, Hong Kong, 11 - 15 January 2009.

Researcher : Zhang Y

List of Research Outputs

Cham W.C., Ma C.W., Zhang Y., Xie H., Yung W.H., Chan Y.S. and Shum D.K.Y., Heparanase modulates synaptic plasticity at the hippocampus, Abstracts of 4th Int’l Symp. on Healthy Aging: Emerging Therapy for an Aging Population: 77. 2009.

Cham W.C., Ma C.W., Zhang Y., Chan Y.S. and Shum D.K.Y., Role of heparanase in synaptic plasticity at the hippocampus and the vestibular nucleus, Proc. 6th Asian Biophysics Association Symposium. 2009, 167-168.

Zhang Y. and Song Y., The Role of Pax6 in Beta-Amyloid Induced Neuronal Death, 13th Research Postgraduate Symposium, December 10 & 11, 2008. HKU. 2008.

Researcher : Zhang Y

List of Research Outputs

Zhang Y. and Song Y., The Role of Pax6 in Beta-Amyloid Induced Neuronal Death, 13th Research Postgraduate Symposium, December 10 & 11, 2008. HKU. 2008.

Researcher : Zheng C

List of Research Outputs

Cheng M.H., Choy R.K.W., Zheng C., Tsang W.H., Tsang S.L., Song Y., Pang C.P. and Sham M.H., A _γA-crystallin Mouse Mutant Secc with Small Eye, Cataract and Closed Eyelid, 13th Research Postgraduate Symposium, HKU December 10 & 11. 2008.

Researcher : Zhou S

List of Research Outputs

Zhou S., Liu B. and Zhou Z., B Cell Development Defect in ZMPSTE24^-/-Mice, 13th Research Postgraduate Symposium, HKU. Hong Kong December 10 & 11. 2008.

Researcher : Zhou Z

List of Research Outputs

Jin G. and Zhou Z., MTI-MMP Supports Development Niche of B Cell Lineage in Bone Marrow, 13th Research Postgraduate Symposium, HKU. Hong Kong December 10 & 11. 2008.

Mimura T., Han K.Y., Onguchi T., Chang J.H., Kim T.I., Kojima T., Zhou Z. and Azar D.T., MT1-MMP-Mediated Cleavage of Decorin in Corneal Angiogenesis., J Vasc Res. 2009, 46(6): 541-550.

Peng S., Zhou G., Li Z., Cheung K.M.C., Luk K.D.K., Zhou Z. and Lu W.W., Strontium Promotes Osteogenic Differentiation Of Mesenchymal Stem Cells Through Enhancing The Ras/erk Mapk Signalling, Cell Physiology and Biechemistry. 2009, 23: 165-174.

Peng S.L., Zhou G., Luk K.D.K., Cheung K.M.C., Li Z., Lam R.W.M., Zhou Z. and Lu W.W., Strontium promotes osteogenic differentiation of mesenchymal stem cells through the Ras/MAPK signaling pathway., Cell Physiol Biochem. 2009, 23: 165-174.

She Z.G., Zheng W., Wei Y.S., Chen H.Z., Wang A.B., Li H.L., Liu G., Zhang R., Liu J.J., Stallcup W.B., Zhou Z., Liu D.P. and Liang C.C., Human paraoxonase gene cluster transgenic overexpression represses atherogenesis and promotes atherosclerotic plaque stability in ApoE-null mice., Circulation Research. . 2009, 104: 1160-1168.

West M.A., Prescott A.R., Chan J.K.M., Zhou Z., Rose-John S., Scheller J. and Watts C., Tlr Ligand-induced Podosome Disassembly In Dendritic Cells Is Adam17 Dependent, J Cell Biol.. USA, 2008, 182: 993-1005.

Wu X., Kong C.T. and Zhou Z., Functional Analysis of the Mouse Isthmin Gene Encoding a Novel Secreted Protein, 13th Research Postgraduate Symposium, HKU. Hong Kong. December 10 & 11. 2008.

Yeung M.N., Zhou Z., Chan D. and Shum D.K.Y., A Novel Non-invasive Role of Heparanase: Promotion of Cartilage Matrix Mineralization, 13th Research Postgraduate Symposium, HKU. December 10 & 11, 2008, Hong Kong. 2008.

Zhang L. and Zhou Z., Prelamin A Induces Cellular Senescence by Activating Heterochromatin Formation, 13th Research Postgraduate Symposium, HKU. Hong Kong December 10 & 11. 2008.

Zhou S., Liu B. and Zhou Z., B Cell Development Defect in ZMPSTE24^-/-Mice, 13th Research Postgraduate Symposium, HKU. Hong Kong December 10 & 11. 2008.

Researcher : Zhu G

List of Research Outputs

Gan H., Zhu G., Wang Z., Chan D., Cheah K.S.E. and Huang J., Study the function of KIF5B in long bone development, 13th Research Postgraduate Symposium, Hong Kong December 10 & 11. 2008.

Gan H., Zhu G., Chan D., Cheah K.S.E. and Huang J., The function of kinesin-1 mediated intracellular transportation in long bone development, Gordon Research Conferences - 2009 Program (Cartilage Biology & Pathology). Les Diablerets Conference Center, Les Diablerets, Switzerland June 7-12. 2009.

Yin Y., Yu V...C..., Zhu G. and Chang D...C..., SET8 plays a role in controlling G1/S transition by blocking lysine acetylation in histone through binding to H4 N-terminal tall, Cell Cycle. 2008, 7: 1423-1432.

Zhu G., Study of the Function of Kinesin-1 (K1F5B) in Long Bone Development, PhD Thesis. 2009.

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