HKU-PASTEUR RESEARCH CENTRE LIMITED
Researcher : Baudon EM |
List of Research Outputs |
Baudon E.M., Trevennec K., Peiris J.S.M., Roger F. and Garcia J., Preliminary laboratory results of an epidemiological study on avian and swine influenza in Vietnam, International symposium on “Surveillance and Discovery in Respiratory and Other Emerging Infectious Diseases. 2011. |
Researcher : Bruzzone R |
Project Title: | Regulation of early steps of coronavirus infection by the ezrin ERM protein |
Investigator(s): | Bruzzone R, Cheung CY, Nal-Rogier BTM |
Department: | Medical Faculty |
Source(s) of Funding: | General Research Fund (GRF) |
Start Date: | 11/2008 |
Completion Date: | 10/2010 |
List of Research Outputs |
Bruzzone R., Helbig I., Sammler E., Eliava M., Bolshakov A. .P., Rozov A., Monyer H. and Hormuzdi S. .G., In vivo evidence for the involvement of the carboxy terminal domain in assembling connexin 36 at the electrical synapse. , Molecular and Cellular Neuroscience. US, Elsevier Inc., 2010, 45 (1-3): 47-58. |
Lam Y.M., Tang D., Chu S.L., Nal-Rogier B.T.M., Bruzzone R. and Lam C.H.P., Identification of Molecular Determinants for Efficient H5pp, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
Leung H.L., Li P.H., Lee H.H.Y., Yip M.S., Bruzzone R. and Jaume M.D.A., Mechanism of Antibody-dependent Enhancement infection of Severe Acute Respiratory Syndrome Coronavirus. , 15th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong. 2010. |
Teoh K.T., Siu Y.L., Chan W.L., Schlüter M.A., Liu C.J., Peiris J.S.M., Bruzzone R., Margolis B. and Nal-Rogier B.T.M., The SARS coronavirus E protein interacts with PALS1 and alters tight junction formation and epithelial morphogenesis., In: Asma Nusrat, Molecular Biology of the Cell. 2010, 21: 3838-3852. |
Yip M.S., Cheung C.Y., Li P.H., Bruzzone R., Peiris J.S.M. and Jaume M.D.A., Investigation of Antibody-Dependent Enhancement (ADE) of SARS Coronavirus Infection and Its Role in Pathogenesis of SARS, International Network of Pasteur Institutes Annual Symposium. 2010. |
Researcher : Chu SL |
List of Research Outputs |
Lam Y.M., Tang D., Chu S.L., Nal-Rogier B.T.M., Bruzzone R. and Lam C.H.P., Identification of Molecular Determinants for Efficient H5pp, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
Researcher : Dutry ICA |
List of Research Outputs |
Dutry I.C.A., Yen H., Lee H.H.Y., Peiris J.S.M. and Jaume M.D.A., Antibody-Dependent Enhancement (ADE) of influenza infection and its possible role in the pathogenesis of influenza. , Institut Pasteur International Network Symposium on Surveillance and Investigation of Respiratory Diseases, Phnom Penh – Cambodia. 2011. |
Dutry I.C.A., Yen H., Lee H.H.Y., Peiris J.S.M. and Jaume M.D.A., Antibody-Dependent Enhancement (ADE) of influenza infection and its possible role in the pathogenesis of influenza., 15th Research Postgraduate Symposium, The University of Hong Kong. 2010. |
Dutry I.C.A., Yen H., Lee H.H.Y., Peiris J.S.M. and Jaume M.D.A., Antibody-Dependent Enhancement (ADE) of influenza infection and its possible role in the pathogenesis of influenza., Annual Scientific Meeting of the Institut Pasteur International Network. 2010. |
Dutry I.C.A., Certificate of Merit for the best poster presentation in “Infection & Immunology” theme, 15th Research Postgraduate Symposium, Hong Kong. . 2010. |
Dutry I.C.A., Yen H., Lee H.H.Y., Peiris J.S.M. and Jaume M.D.A., Dutry I., Yen H.L., Lee H., Peiris J.S.M., & Jaume M. Antibody-Dependent Enhancement (ADE) of influenza infection and its possible role in the pathogenesis of influenza, Options for the Control of Influenza VII. 2010. |
Researcher : Garcia J |
List of Research Outputs |
Baudon E.M., Trevennec K., Peiris J.S.M., Roger F. and Garcia J., Preliminary laboratory results of an epidemiological study on avian and swine influenza in Vietnam, International symposium on “Surveillance and Discovery in Respiratory and Other Emerging Infectious Diseases. 2011. |
Bethell D., Jongkaewwattana A., Kramyu J., Thitithayanont A., Wiboon-ut S., Saunders D., Yongvanitchit K., Limsalakpetch A., Kum-Arb U., Uthaimongkol N., Garcia J., Peiris J.S.M., Thomas S., Engering A., Jarman R., Mongkolsirichaikul D., Mason C., Khemnu N., Tyner S. and Walsh D., Evaluation of in vitro cross-reactivity with avian influenza H5N1 and swine flu H1N1 2009 viruses in healthy volunteers vaccinated with a prime boost regimen of seasonal influenza vaccine, Keystone symposia, Seattle. 2010. |
Garcia J., Cell-based assay: application to drug discovery, International training course “Animal cell biotechnology: production from cells-cells as products". 2010. |
Garcia J., Buchy P., Cavailler P., de Jong M. and Peiris J.S.M., Influenza Pseudotyped lentivirus-A flexible useful tool for influenza research, International symposium on “Surveillance and Discovery in Respiratory and Other Emerging Infectious Diseases”. 2011. |
Garcia J. and Lai J.C.C., Production of influenza pseudotyped lentiviral particles and its use in flu research and diagnosis-an update, Expert Rev. Anti Infect. Ther. . 2011, 9: 443-455. |
Lai J.C.C., Nicholls J.M., Peiris J.S.M. and Garcia J., Formation of virus-like particles from human cell lines exclusively expressing Influenza Neuraminidase, International Network Institut Pasteur Annual meeting. 2010. |
Researcher : Jaume MDA |
List of Research Outputs |
Dutry I.C.A., Yen H., Lee H.H.Y., Peiris J.S.M. and Jaume M.D.A., Antibody-Dependent Enhancement (ADE) of influenza infection and its possible role in the pathogenesis of influenza. , Institut Pasteur International Network Symposium on Surveillance and Investigation of Respiratory Diseases, Phnom Penh – Cambodia. 2011. |
Dutry I.C.A., Yen H., Lee H.H.Y., Peiris J.S.M. and Jaume M.D.A., Antibody-Dependent Enhancement (ADE) of influenza infection and its possible role in the pathogenesis of influenza., 15th Research Postgraduate Symposium, The University of Hong Kong. 2010. |
Dutry I.C.A., Yen H., Lee H.H.Y., Peiris J.S.M. and Jaume M.D.A., Antibody-Dependent Enhancement (ADE) of influenza infection and its possible role in the pathogenesis of influenza., Annual Scientific Meeting of the Institut Pasteur International Network. 2010. |
Dutry I.C.A., Yen H., Lee H.H.Y., Peiris J.S.M. and Jaume M.D.A., Dutry I., Yen H.L., Lee H., Peiris J.S.M., & Jaume M. Antibody-Dependent Enhancement (ADE) of influenza infection and its possible role in the pathogenesis of influenza, Options for the Control of Influenza VII. 2010. |
Jaume M.D.A., Monitoring by flow cytometry of antigen-specific proliferative response of mouse spleen cells., 3rd HKU-Pasteur Immunology Course - Pathogen sensing and cross-talk between innate & adaptive immunity. 2010. |
Leung H.L., Li P.H., Lee H.H.Y., Yip M.S., Bruzzone R. and Jaume M.D.A., Mechanism of Antibody-dependent Enhancement infection of Severe Acute Respiratory Syndrome Coronavirus. , 15th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong. 2010. |
Yip M.S. and Jaume M.D.A., Antibody-dependent Enhancement of Severe Acute Respiratory Syndrome Coronavirus, 15th Research Postgraduate Symposium. Li Ka Shing Faculty of Medicine, HKU. 2010. |
Yip M.S., Cheung C.Y., Li P.H., Bruzzone R., Peiris J.S.M. and Jaume M.D.A., Investigation of Antibody-Dependent Enhancement (ADE) of SARS Coronavirus Infection and Its Role in Pathogenesis of SARS, International Network of Pasteur Institutes Annual Symposium. 2010. |
Researcher : Lai JCC |
List of Research Outputs |
Garcia J. and Lai J.C.C., Production of influenza pseudotyped lentiviral particles and its use in flu research and diagnosis-an update, Expert Rev. Anti Infect. Ther. . 2011, 9: 443-455. |
Lai J.C.C., Nicholls J.M., Peiris J.S.M. and Garcia J., Formation of virus-like particles from human cell lines exclusively expressing Influenza Neuraminidase, International Network Institut Pasteur Annual meeting. 2010. |
Researcher : Lee HHY |
List of Research Outputs |
Dutry I.C.A., Yen H., Lee H.H.Y., Peiris J.S.M. and Jaume M.D.A., Antibody-Dependent Enhancement (ADE) of influenza infection and its possible role in the pathogenesis of influenza. , Institut Pasteur International Network Symposium on Surveillance and Investigation of Respiratory Diseases, Phnom Penh – Cambodia. 2011. |
Dutry I.C.A., Yen H., Lee H.H.Y., Peiris J.S.M. and Jaume M.D.A., Antibody-Dependent Enhancement (ADE) of influenza infection and its possible role in the pathogenesis of influenza., 15th Research Postgraduate Symposium, The University of Hong Kong. 2010. |
Dutry I.C.A., Yen H., Lee H.H.Y., Peiris J.S.M. and Jaume M.D.A., Antibody-Dependent Enhancement (ADE) of influenza infection and its possible role in the pathogenesis of influenza., Annual Scientific Meeting of the Institut Pasteur International Network. 2010. |
Dutry I.C.A., Yen H., Lee H.H.Y., Peiris J.S.M. and Jaume M.D.A., Dutry I., Yen H.L., Lee H., Peiris J.S.M., & Jaume M. Antibody-Dependent Enhancement (ADE) of influenza infection and its possible role in the pathogenesis of influenza, Options for the Control of Influenza VII. 2010. |
Leung H.L., Li P.H., Lee H.H.Y., Yip M.S., Bruzzone R. and Jaume M.D.A., Mechanism of Antibody-dependent Enhancement infection of Severe Acute Respiratory Syndrome Coronavirus. , 15th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong. 2010. |
Researcher : Li PH |
List of Research Outputs |
Leung H.L., Li P.H., Lee H.H.Y., Yip M.S., Bruzzone R. and Jaume M.D.A., Mechanism of Antibody-dependent Enhancement infection of Severe Acute Respiratory Syndrome Coronavirus. , 15th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong. 2010. |
Yip M.S., Cheung C.Y., Li P.H., Bruzzone R., Peiris J.S.M. and Jaume M.D.A., Investigation of Antibody-Dependent Enhancement (ADE) of SARS Coronavirus Infection and Its Role in Pathogenesis of SARS, International Network of Pasteur Institutes Annual Symposium. 2010. |
Researcher : Mok KP |
List of Research Outputs |
Yuen K.M., Chan W.Y., Mok K.P., Wong C.N., Kang S.R., Nicholls J.M. and Chan M.C.W., Differential onset of apoptosis in avian influenza H5N1 and seasonal H1N1 virus infected human bronchial and alveolar epithelial cells: an in vitro and ex vivo study, Influenza and other respiratory viruses. 2011, 5 (S1): 437-438. |
Researcher : Nal-Rogier BTM |
List of Research Outputs |
Lam Y.M., Tang D., Chu S.L., Nal-Rogier B.T.M., Bruzzone R. and Lam C.H.P., Identification of Molecular Determinants for Efficient H5pp, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
Researcher : Peiris JSM |
Project Title: | IV International Symposium on Respiratory Viral Infections The Influenza Disease Burden in Hong Kong: the Rates of Hospitalisation in Children |
Investigator(s): | Peiris JSM |
Department: | Microbiology |
Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
Start Date: | 11/2001 |
Project Title: | Influenza pandemic preparedness in Asia (Research collaboration with national Institute of Allergy and Infectious Diseases (NIAID), St. Jude Children's Research Hospital, Inc. (SJCRH) and The University of Hong Kong) |
Investigator(s): | Peiris JSM, Guan Y |
Department: | Microbiology |
Source(s) of Funding: | National Institutes of Health, US Department of Health and Human Services - General Award |
Start Date: | 04/2003 |
Project Title: | Virus-cell interaction and the pathogenesis of SARS |
Investigator(s): | Peiris JSM |
Department: | Microbiology |
Source(s) of Funding: | VCO SARS Research Fund |
Start Date: | 07/2003 |
Project Title: | Viral determinants underlying the increased secretion of pro-inflammatory cytokines in H5N1 infected human macrophages: a mechanism for the unusual severity of human H5N1 disease? |
Investigator(s): | Peiris JSM, Guan Y, Lau ASY, Poon LLM |
Department: | Microbiology |
Source(s) of Funding: | General Research Fund (GRF) |
Start Date: | 09/2003 |
Project Title: | The macrophage in the pathogenesis of Severe Acute Respiratory Syndrome Coronavirus infection |
Investigator(s): | Peiris JSM |
Department: | Microbiology |
Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
Start Date: | 12/2005 |
Project Title: | Mass Tag PCR: A novel, multiplex and potentially sensitive approach for the rapid detection of respiratory pathogens |
Investigator(s): | Peiris JSM, Chiu SSS, Cheung CY |
Department: | Microbiology |
Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
Start Date: | 06/2006 |
Project Title: | The pathogenesis of avian influenza A H5N1 in humans: macrophage and epithelial cell-virus interactions in vitro and ex-vivo |
Investigator(s): | Peiris JSM |
Department: | Microbiology |
Source(s) of Funding: | The Wellcome Trust - General Award |
Start Date: | 01/2007 |
Project Title: | Communicable Diseases Surveillance and Response (CSR) - Standardization and shipment of PCR diagnostic kit for Avian Influenza detection to Member countries (viz: Bangladesh, Indonesia, Myanmar, Sri Lanka and Thailand) |
Investigator(s): | Peiris JSM |
Department: | Microbiology |
Source(s) of Funding: | Collaborating Project Fund |
Start Date: | 06/2007 |
Project Title: | Control of Pandemic and Inter-pandemic Influenza |
Investigator(s): | Peiris JSM, Guan Y, Yuen KY, Chen H, Leung GM, Lau YL |
Department: | Microbiology |
Source(s) of Funding: | Areas of Excellence Scheme |
Start Date: | 01/2008 |
Project Title: | Effector roles of cytokine cascades in the pathogenesis of human H5N1 disease |
Investigator(s): | Peiris JSM, Cheung CY, Lee MY, Nicholls JM |
Department: | Microbiology |
Source(s) of Funding: | General Research Fund (GRF) |
Start Date: | 01/2008 |
Project Title: | The role of Toll-like receptor 10 (TLR10) as an innate immune sensor for respiratory viral infections |
Investigator(s): | Peiris JSM, Lee MY, Nicholls JM |
Department: | Microbiology |
Source(s) of Funding: | General Research Fund (GRF) |
Start Date: | 01/2011 |
List of Research Outputs |
Baudon E.M., Trevennec K., Peiris J.S.M., Roger F. and Garcia J., Preliminary laboratory results of an epidemiological study on avian and swine influenza in Vietnam, International symposium on “Surveillance and Discovery in Respiratory and Other Emerging Infectious Diseases. 2011. |
Bethell D., Jongkaewwattana A., Kramyu J., Thitithayanont A., Wiboon-ut S., Saunders D., Yongvanitchit K., Limsalakpetch A., Kum-Arb U., Uthaimongkol N., Garcia J., Peiris J.S.M., Thomas S., Engering A., Jarman R., Mongkolsirichaikul D., Mason C., Khemnu N., Tyner S. and Walsh D., Evaluation of in vitro cross-reactivity with avian influenza H5N1 and swine flu H1N1 2009 viruses in healthy volunteers vaccinated with a prime boost regimen of seasonal influenza vaccine, Keystone symposia, Seattle. 2010. |
Dutry I.C.A., Yen H., Lee H.H.Y., Peiris J.S.M. and Jaume M.D.A., Antibody-Dependent Enhancement (ADE) of influenza infection and its possible role in the pathogenesis of influenza. , Institut Pasteur International Network Symposium on Surveillance and Investigation of Respiratory Diseases, Phnom Penh – Cambodia. 2011. |
Dutry I.C.A., Yen H., Lee H.H.Y., Peiris J.S.M. and Jaume M.D.A., Antibody-Dependent Enhancement (ADE) of influenza infection and its possible role in the pathogenesis of influenza., 15th Research Postgraduate Symposium, The University of Hong Kong. 2010. |
Dutry I.C.A., Yen H., Lee H.H.Y., Peiris J.S.M. and Jaume M.D.A., Antibody-Dependent Enhancement (ADE) of influenza infection and its possible role in the pathogenesis of influenza., Annual Scientific Meeting of the Institut Pasteur International Network. 2010. |
Dutry I.C.A., Yen H., Lee H.H.Y., Peiris J.S.M. and Jaume M.D.A., Dutry I., Yen H.L., Lee H., Peiris J.S.M., & Jaume M. Antibody-Dependent Enhancement (ADE) of influenza infection and its possible role in the pathogenesis of influenza, Options for the Control of Influenza VII. 2010. |
Garcia J., Buchy P., Cavailler P., de Jong M. and Peiris J.S.M., Influenza Pseudotyped lentivirus-A flexible useful tool for influenza research, International symposium on “Surveillance and Discovery in Respiratory and Other Emerging Infectious Diseases”. 2011. |
Hui P.Y., Lee M.Y., Cheung C.Y., Peiris J.S.M. and Peiris J.S.M., The Role of Innate Sensing Receptors in H5N1 Associated Hyper-induction of Cytokines , Influenza and other respiratory viruses. Oxford, UK, Wiley-Blackwell, 2011, 5: 269-272. |
Hui P.Y., Lee M.Y., Cheung C.Y., Peiris J.S.M. and Peiris J.S.M., The Role of Innate Sensing Receptors in H5N1 Associated Hyper-induction of Cytokines , Options for the Control of Influenza VII. 2010. |
Hui P.Y., Lee M.Y., Cheung C.Y., Peiris J.S.M. and Peiris J.S.M., The Role of Innate Sensing Receptors in Highly Pathogenic Avian Influenza (HPAI) H5N1 Associated Hyper-induction of Cytokines, Keystone Symposia: Pathogenesis of Influenza: Virus-Host Interactions. Hong Kong SAR, China, 2011, 129. |
Lai J.C.C., Nicholls J.M., Peiris J.S.M. and Garcia J., Formation of virus-like particles from human cell lines exclusively expressing Influenza Neuraminidase, International Network Institut Pasteur Annual meeting. 2010. |
Ng Y.P., Lee M.Y., Cheung K.W., Nicholls J.M., Peiris J.S.M. and Ip N.Y., Avian influenza H5N1 virus induces cytopathy and proinflammatory cytokine responses in human astrocytic and neuronal cell lines, Neuroscience. 2010, 168(3): 613-23. |
Teoh K.T., Siu Y.L., Chan W.L., Schlüter M.A., Liu C.J., Peiris J.S.M., Bruzzone R., Margolis B. and Nal-Rogier B.T.M., The SARS coronavirus E protein interacts with PALS1 and alters tight junction formation and epithelial morphogenesis., In: Asma Nusrat, Molecular Biology of the Cell. 2010, 21: 3838-3852. |
Yip M.S., Cheung C.Y., Li P.H., Bruzzone R., Peiris J.S.M. and Jaume M.D.A., Investigation of Antibody-Dependent Enhancement (ADE) of SARS Coronavirus Infection and Its Role in Pathogenesis of SARS, International Network of Pasteur Institutes Annual Symposium. 2010. |
Researcher : Siu YL |
List of Research Outputs |
Teoh K.T., Siu Y.L., Chan W.L., Schlüter M.A., Liu C.J., Peiris J.S.M., Bruzzone R., Margolis B. and Nal-Rogier B.T.M., The SARS coronavirus E protein interacts with PALS1 and alters tight junction formation and epithelial morphogenesis., In: Asma Nusrat, Molecular Biology of the Cell. 2010, 21: 3838-3852. |
Researcher : Tang D |
List of Research Outputs |
Lam Y.M., Tang D., Chu S.L., Nal-Rogier B.T.M., Bruzzone R. and Lam C.H.P., Identification of Molecular Determinants for Efficient H5pp, 15th Research Postgraduate Symposium, HKU, 1-2 Dec 2010. HK. |
Researcher : Yen H |
Project Title: | The role of balanced hemagglutinin-neuraminidase activity on the genesis of transmissible NA inhibitor-resistant variants in seasonal and novel pandemic influenza A H1N1 viruses |
Investigator(s): | Yen H, Peiris JSM |
Department: | Microbiology |
Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
Start Date: | 01/2010 |
Project Title: | Role of influenza hemagglutinin glycoprotein in activation of dendritic cells and induction of effective immune response through C-type lectin receptors |
Investigator(s): | Yen H, Peiris JSM, Tu W |
Department: | Microbiology |
Source(s) of Funding: | General Research Fund (GRF) |
Start Date: | 01/2011 |
List of Research Outputs |
Dutry I.C.A., Yen H., Lee H.H.Y., Peiris J.S.M. and Jaume M.D.A., Antibody-Dependent Enhancement (ADE) of influenza infection and its possible role in the pathogenesis of influenza. , Institut Pasteur International Network Symposium on Surveillance and Investigation of Respiratory Diseases, Phnom Penh – Cambodia. 2011. |
Dutry I.C.A., Yen H., Lee H.H.Y., Peiris J.S.M. and Jaume M.D.A., Antibody-Dependent Enhancement (ADE) of influenza infection and its possible role in the pathogenesis of influenza., 15th Research Postgraduate Symposium, The University of Hong Kong. 2010. |
Dutry I.C.A., Yen H., Lee H.H.Y., Peiris J.S.M. and Jaume M.D.A., Antibody-Dependent Enhancement (ADE) of influenza infection and its possible role in the pathogenesis of influenza., Annual Scientific Meeting of the Institut Pasteur International Network. 2010. |
Dutry I.C.A., Yen H., Lee H.H.Y., Peiris J.S.M. and Jaume M.D.A., Dutry I., Yen H.L., Lee H., Peiris J.S.M., & Jaume M. Antibody-Dependent Enhancement (ADE) of influenza infection and its possible role in the pathogenesis of influenza, Options for the Control of Influenza VII. 2010. |
Yen H. and Yen H., Animal models for the study of influenza virus pathogenesis and transmission, 7th HKU-Pasterur Research Center Virology Course, 2010. 2010. |
Researcher : Yip MS |
List of Research Outputs |
Leung H.L., Li P.H., Lee H.H.Y., Yip M.S., Bruzzone R. and Jaume M.D.A., Mechanism of Antibody-dependent Enhancement infection of Severe Acute Respiratory Syndrome Coronavirus. , 15th Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong. 2010. |
Yip M.S. and Jaume M.D.A., Antibody-dependent Enhancement of Severe Acute Respiratory Syndrome Coronavirus, 15th Research Postgraduate Symposium. Li Ka Shing Faculty of Medicine, HKU. 2010. |
Yip M.S., Cheung C.Y., Li P.H., Bruzzone R., Peiris J.S.M. and Jaume M.D.A., Investigation of Antibody-Dependent Enhancement (ADE) of SARS Coronavirus Infection and Its Role in Pathogenesis of SARS, International Network of Pasteur Institutes Annual Symposium. 2010. |
Yip M.S., Severe Acute Respiratory Syndrome Coronavirus Infection of Human Immune Cells through Antibody-mediated Pathway., PhD thesis. HKU. 2011. |