DEPT OF MICROBIOLOGY
| Researcher : Ang L |
| Project Title: | Investigation of the Evolution Mechanism(s) and Changes in Antimicrobial Resistance Pattern of the Emerging Non-Vaccine Serotypes (NVT) of Streptococcus pneumoniae After the Introduction of Pneumococcal Conjugate Vaccine (PCV-7) in Hong Kong |
| Investigator(s): | Ang L, Ho PL |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2010 |
| Completion Date: | 10/2011 |
| List of Research Outputs |
| Ho P.L., Lo W.U., Yeung M.K., Lin C., Chow K.H., Ang L., Tong A.H.Y., Bao Y., Lok S. and Lo J.Y., Complete sequencing of pNDM-HK encoding NDM-1 carbapenemase from a multidrug-resistant Escherichia coli strain isolated in Hong Kong. , PLoS One. 2011, 6: e17989. |
| Ho P.L., Chiu S.S.S., Ang L. and Lau Y.L., Serotypes and antimicrobial susceptibilities of invasive Streptococcus pneumoniae before and after introduction of 7-valent pneumococcal conjugate vaccine, Hong Kong, 1995-2009., Vaccine. 2011, 29(17): 3270-3275. |
| Ho P.L., Ang L., Chow K.H., Lai E.L.Y. and Chiu S.S.S., The prevalence and characteristics of Streptococcus pneumoniae isolates expressing serotypes 6C and 6D in Hong Kong prior to the introduction of the 7-valent pneumococcal conjugate vaccine , Diagnostic Microbiology and Infectious Disease. 2010. |
| Researcher : Bahl J |
| List of Research Outputs |
| Dhanasekaran V., Smith G.J., Pybus O.G., Zhu H., Bahl J., Poon L.L.M., Riley S., Bahl J., Ma S.K., Cheung C.L., Perera R.A.P.M., Chen H., Shortridge K.F., Webby R., Guan Y. and Peiris J.S.M., Long-term evolution and transmission dynamics of swine influenza A virus., Nature. 2011, 473: 519-22. |
| Huang K., Bahl J., Fan X... .H..., Dhanasekaran V., Cheung C.L., Webby R... .J..., Webster R... .G..., Chen H., Smith G.J., Peiris J.S.M. and Guan Y., Establishment of an H6N2 Influenza Virus Lineage in Domestic Ducks in Southern China., J Virol. 2010, 84: 6978-86. |
| Researcher : Cao T |
| List of Research Outputs |
| Cao T., Chen M. and Zheng B., Ientification and Evaluation of Protective Ability of a T Cell Epitope Targeting Nucleoprotein of H5N1 influenza virus. , 1st European Conference of Microbiology and Immunology.. Budapest, Hungary., 2011. |
| Zhang N., Lin Y., Chen M., Zhang Q., Cao T. and Zheng B., Swine-Origin Influenza Virus Like Particle Vaccine Conferred Complete Protection Against Lethal Viral Challenge in Balb/C Mice., 1st European Conference of Microbiology and Immunology.. Budapest, Hungary., 2011. |
| Researcher : Chan CS |
| List of Research Outputs |
| Chan K.H., Zhang J., To K.K.W., Chan C.S., Poon K.M., Guo K., Ng F., Zhang Q., Leung H.C., Cheung A.N.Y., Lau C.Y., Woo P.C.Y., Tse H., Wu W.L., Chen H., Zheng B. and Yuen K.Y., Wild type and mutant 2009 pandemic influenza A (H1N1) viruses cause more severe disease and higher mortality in pregnant BALB/c mice, PLoS One. 2010, 5: e13757. |
| Du L., Leung H.C., Zhang X., Zhou J., Chen M., He W., Zhang H., Chan C.S., Poon K.M., Zhao G., Sun S., Cai L., Zhou Y., Zheng B. and Jiang S., A recombinant vaccine of H5N1 HA1 fused with foldon and human IgG Fc induced complete cross-clade protection against divergent H5N1 viruses., PloS One. 2011, 6(1):: e16555. |
| Liu S., Li R., Zhang R., Chan C.S., Xi B., Zhu Z., Yang J., Poon K.M., Zhou J., Chen M., Munch J., Kirchhoff F., Pleschka S., Haarmann T., Dietrich U., Pan C., Du L., Jiang S. and Zheng B., CL-385319 inhibits H5N1 avian influenza A virus infection by blocking viral entry. , Eur J Pharmacol . 2011, 660:: 460-467. |
| Zhao G., Lin Y., Guan J., Du L., Sui H., Chan C.S., Kou Z., Guo Y., Jiang S., Zhou Y. and Zheng B., An M2e-based polypeptide vaccine protects mice from lethal challenge with divergent H5N1 influenza viruses., 4TH Congress of European Microbiologists . Geneva, Switzerland., 2011. |
| Zheng B., Chan K.H., Zhang J., Zhou J., Chan C.S., Poon K.M., Zhang K., Leung H.C., Jin D., Woo P.C.Y., Chan J.F.W., To K.K.W., Chen H. and Yuen K.Y., D225G mutation in haemagglutinin of pandemic Influenza H1N1 (2009) virus enhances virulence in mice, Experimental Biology and Medicine. 2010, 235: 981-8. |
| Zheng B., Du L., Zhao G., Lin Y., Sui H., Chan C.S., He Y., Jiang S., Zhou Y. and Yuen K.Y., SARS-CoV S Protein Induces Strong Mucosal Immune Responses and Provides Long-term Protection Against SARS-CoV Infection., In: Eighth International Symposium on Frontiers in Life Sciences New Advances and Challenges in Multidisciplinary Research., Yinchuan, China., 2010. |
| Researcher : Chan E |
| List of Research Outputs |
| Tang S.F., Chan J.F.W., Chen M., Tsang O.T.Y., Mok M.Y., Lai W.Y.M., Lee R.A., Que T.L., Tse H., Li W.S., To K.K.W., Cheng V.C.C., Chan E., Zheng B. and Yuen K.Y., Disseminated penicilliosis, recurrent bacteremic non-typhoidal salmonellosis and burkholderiosis associated with acquired immunodeficiency due to autoantibody against interferon gamma., Clin Vaccine Immunol. 2010, 17(7):: 1132-1138. |
| Researcher : Chan JFW |
| List of Research Outputs |
| Chan J.F.W., Hwang G.Y., Lamb S., Chan G.S.W., So J.C.C., Leung S.S., To K.K.W., Li W.S., Cheng V.C.C. and Yuen K.Y., Pneumococcal native aortic valve endocarditis with mycotic abdominal aortic aneurysm, paraspinal and iliopsoas abscesses and pneumonia revealing a multiple myeloma, J Med Microbiol. 2011, 60(Pt 6): 851-5. |
| Chan J.F.W., To K.K.W., Tse H., Lau C.Y., Li W.S., Hung I.F.N., Chan K.H., Cheng V.C.C., Lai T.S.T., Woo P.C.Y., Chan E.Y.T. and Yuen K.Y., The lower serum immunoglobulin G2 level in severe cases than in mild cases of pandemic H1N1 2009 influenza is associated with cytokine dysregulation, Clinical and Vaccine Immunology. 2010, 18: 305-310. |
| Chan K.H., To K.K.W., Hung I.F.N., Zhang J., Chan J.F.W., Cheng V.C.C., Tse H., Che X.Y., Chen H. and Yuen K.Y., Differences in antibody responses of individuals with natural infection and those vaccinated against pandemic H1N1 2009 influenza., Clinical Vaccine Immunology. 2011, 18: 867-73. |
| Cheng V.C.C., Chan J.F.W., Wen X., Wu W.L., Que T.L., Chen H., Chan K.H. and Yuen K.Y., Infection of immunocompromised patients by avian H9N2 influenza A virus, J Infect.. 2011, 62: 394-9. |
| Cheng V.C.C., Wong L.M., Tai J.W., Chan J.F.W., To K.K.W., Li W.S., Hung I.F.N., Chan K.H., Ho P.L. and Yuen K.Y., Prevention of nosocomial transmission of norovirus by strategic infection control measures, Infection control and hospital epidemiology. 2011, 32(3): 229-37. |
| Cheng V.C.C., Tai J.W.M., Chan W.M., Lau E.H.Y., Chan J.F.W., To K.K.W., Li W.S., Ho P.L. and Yuen K.Y., Sequential introduction of single room isolation and hand hygiene campaign in the control of methicillin-resistant Staphylococcus aureus in intensive care unit., BMC infectious diseases. 2010, 10: 263. |
| Cheng V.C.C., Chan J.F.W., Lau E.H.Y., Yam W.C., Ho S.K.Y., Yau M.C.Y., Tse E.Y.F., Wong A.C.Y., Tai J.W.M., Fan S.T., Ho P.L. and Yuen K.Y., Studying the transmission dynamics of meticillin-resistant Staphylococcus aureus in Hong Kong using spa typing, Journal of Hospital Infection. 2011, 79(3): 206-210. |
| Hung I.F.N., To K.K.W., Lee C.K., Lin C.K., Chan J.F.W., Tse H., Cheng V.C.C., Chen H., Ho P.L., Tse C.W., Ng T.K., Que T.L., Chan K.H. and Yuen K.Y., Effect of Clinical and Virological Parameters on the Level of Neutralizing Antibody against Pandemic Influenza A Virus H1N1 2009, Clin Infect Dis.. 2010, 51: 274-9. |
| Hung I.F.N., To K.K.W., Lee C.K., Lin C.K., Chan J.F.W., Tse H., Cheng V.C.C., Chen H., Ho P.L., Tse C.W.S., Ng T.K., Que T.L., Chan K.H. and Yuen K.Y., Effect of clinical and virological parameters on the level of neutralizing antibody against pandemic influenza A virus H1N1 2009., Clinical Infectious Disease. 2010, 51: 274-9. |
| Tang S.F., Chan J.F.W., Chen M., Tsang O.T.Y., Mok M.Y., Lai W.Y.M., Lee R.A., Que T.L., Tse H., Li W.S., To K.K.W., Cheng V.C.C., Chan E., Zheng B. and Yuen K.Y., Disseminated penicilliosis, recurrent bacteremic non-typhoidal salmonellosis and burkholderiosis associated with acquired immunodeficiency due to autoantibody against interferon gamma., Clin Vaccine Immunol. 2010, 17(7):: 1132-1138. |
| To K.K.W., Cheng V.C.C., Chan J.F.W., Wong A.C., Chau S., Tsang F.H.F., Curreem S.O.T., Lau S.K.P., Yuen K.Y. and Woo P.C.Y., Molecular characterization of a catalase-negative Staphylococcus aureus subsp. aureus from a patient with mitral valve endocarditis and pericarditis revealed novel nonsense mutation in katA gene., Journal of Clinical Microbiology. 2011. |
| Zheng B., Chan K.H., Zhang J., Zhou J., Chan C.S., Poon K.M., Zhang K., Leung H.C., Jin D., Woo P.C.Y., Chan J.F.W., To K.K.W., Chen H. and Yuen K.Y., D225G mutation in haemagglutinin of pandemic Influenza H1N1 (2009) virus enhances virulence in mice, Experimental Biology and Medicine. 2010, 235: 981-8. |
| Researcher : Chan KCW |
| List of Research Outputs |
| Chen J.H.K., Wong K.H., Chen Z., Chan K.C.W., Lam H.Y., To W.C.S., Cheng V.C.C., Yuen K.Y. and Yam W.C., Increased Genetic Diversity of HIV-1 Circulating in Hong Kong, In: Vlsdimir N., PLoS One. 2010, 5: e12198. |
| Researcher : Chan KH |
| List of Research Outputs |
| Chan J.F.W., To K.K.W., Tse H., Lau C.Y., Li W.S., Hung I.F.N., Chan K.H., Cheng V.C.C., Lai T.S.T., Woo P.C.Y., Chan E.Y.T. and Yuen K.Y., The lower serum immunoglobulin G2 level in severe cases than in mild cases of pandemic H1N1 2009 influenza is associated with cytokine dysregulation, Clinical and Vaccine Immunology. 2010, 18: 305-310. |
| Chan K.H., To K.K.W., Hung I.F.N., Zhang J., Chan J.F.W., Cheng V.C.C., Tse H., Che X.Y., Chen H. and Yuen K.Y., Differences in antibody responses of individuals with natural infection and those vaccinated against pandemic H1N1 2009 influenza., Clinical Vaccine Immunology. 2011, 18: 867-73. |
| Chan K.H., Zhang J., To K.K.W., Chan C.S., Poon K.M., Guo K., Ng F., Zhang Q., Leung H.C., Cheung A.N.Y., Lau C.Y., Woo P.C.Y., Tse H., Wu W.L., Chen H., Zheng B. and Yuen K.Y., Wild type and mutant 2009 pandemic influenza A (H1N1) viruses cause more severe disease and higher mortality in pregnant BALB/c mice, PLoS One. 2010, 5: e13757. |
| Cheng V.C.C., Chan J.F.W., Wen X., Wu W.L., Que T.L., Chen H., Chan K.H. and Yuen K.Y., Infection of immunocompromised patients by avian H9N2 influenza A virus, J Infect.. 2011, 62: 394-9. |
| Cheng V.C.C., Wong L.M., Tai J.W., Chan J.F.W., To K.K.W., Li W.S., Hung I.F.N., Chan K.H., Ho P.L. and Yuen K.Y., Prevention of nosocomial transmission of norovirus by strategic infection control measures, Infection control and hospital epidemiology. 2011, 32(3): 229-37. |
| Chiu S.S.S., Chan K.H., Wong W.H.S., Chan L.Y. and Peiris J.S.M., Age-matched comparison of children hospitalized for 2009 pandemic H1N1 influenza with those hospitalized for seasonal H1N1 and H3N2, PLoS ONE. 2011, 6 (7): e21837. |
| Chiu S.S.S., Chan K.H., Chen H., Young B.W.Y., Lim W., Wong W.H.S. and Peiris J.S.M., Virologically confirmed population-based burden of hospitalization caused by respiratory syncytial virus, adenovirus, and parainfluenza viruses in children in Hong Kong, The Pediatric Infectious Disease Journal [Epub ahead]. 2010, 29(12). |
| Chu K.W., Chin W.H., Smith G.J., Chan K.H., Guan Y., Peiris J.S.M. and Poon L.L.M., Detection of novel astroviruses in urban brown rats and previously known astroviruses in humans., J Gen Virol. . 2010, 91: 2457-2462. |
| Cowling B.J., Ng S., Ma S.K., Cheng K.Y., Lim Wai W.S., Fang J., Chan K.H., Ip D.K.M., Chiu S.S.S., Peiris J.S.M. and Leung G.M., Protective Efficacy of Seasonal Influenza Vaccination against Seasonal and Pandemic Influenza Virus Infection during 2009 in Hong Kong, Clinical Infectious Diseases. 2010, 51(12): 1370-1379. |
| Cowling B.J., Ng S., Cheng K.Y., Lim Wai W.S., Fang J., Chan K.H., Ma E.S.K., Ip D.K.M., Chiu S.S.S., Peiris J.S.M. and Leung G.M., The effectiveness of seasonal influenza vaccine in preventing pandemic and seasonal influenza infection: a randomized controlled trial (Options for the Control of Influenza VII, 3-7 September 2010, Hong Kong), Influenza and Other Respiratory Viruses. 2010, 5(Suppl 1): 328-332. |
| Hung I.F.N., To K.K.W., Lee C...K..., Lee K...L..., Chan K..., Yan W...W..., Liu R..., Watt C...L..., Chan W.M., Lai K...Y..., Koo C...K..., Buckley T..., Chow F...L..., Wong K...K..., Chan H...S..., Ching C...K..., Tang B...S...F..., Lau C.Y., Li W.S., Liu S...H..., Chan K.H., Lin C...K... and Yuen K.Y., Convalescent plasma treatment reduced mortality in patients with severe pandemic influenza A (H1N1) 2009 virus infection , Clinical Infectious Diseases. 2011, 52(4): 447-456. |
| Hung I.F.N., To K.K.W., Lee C.K., Lin C.K., Chan J.F.W., Tse H., Cheng V.C.C., Chen H., Ho P.L., Tse C.W., Ng T.K., Que T.L., Chan K.H. and Yuen K.Y., Effect of Clinical and Virological Parameters on the Level of Neutralizing Antibody against Pandemic Influenza A Virus H1N1 2009, Clin Infect Dis.. 2010, 51: 274-9. |
| Hung I.F.N., To K.K.W., Lee C.K., Lin C.K., Chan J.F.W., Tse H., Cheng V.C.C., Chen H., Ho P.L., Tse C.W.S., Ng T.K., Que T.L., Chan K.H. and Yuen K.Y., Effect of clinical and virological parameters on the level of neutralizing antibody against pandemic influenza A virus H1N1 2009., Clinical Infectious Disease. 2010, 51: 274-9. |
| Lau L.H.L., Fang J., Chan K.H., Cheng K.Y., Peiris J.S.M., Leung G.M. and Cowling B.J., Patterns of viral shedding in pandemic and seasonal influenza virus infections in a community setting (Options for the Control of Influenza VII, 3-7 September 2010, Hong Kong), Influenza and Other Respiratory Viruses. 2010, 5(Suppl 1): 301-303. |
| Lau L.L.H., Chan K.H., Fang J., Cheng K.Y., Ma E.S.K., Ip D.K.M., Leung G.M., Peiris J.S.M. and Cowling B.J., Association of antibody titer measured by hemagglutination inhibition with protection from influenza virus infection and illness in a community setting (abstract), Options for the Control of Influenza VII Conference, 3-7 September 2010, Hong Kong. Hong Kong, Int’l Society for Influenza & Other Respiratory Virus Dis, 2010, 231. |
| Lau L.L.H., Chan K.H., Fang J., Cheng K.Y., Ma S.K., Ip D.K.M., Leung G.M., Peiris J.S.M. and Cowling B.J., Baseline hemagglutination inhibition titer levels and protection against naturally acquired influenza virus infection and illness (abstract and poster presentation), HKCCM International Conference, 4-6 September 2010, Hong Kong. Hong Kong, Hong Kong College of Community Medicine, 2010, 60. |
| Lau S.K.P., Woo P.C.Y., Yip C.Y., Li K.S.M., Fu C.T., Huang Y., Chan K.H. and Yuen K.Y., Co-existence of multiple strains of two novel porcine bocaviruses in the same pig, a previously undescribed phenomenon in members of the family Parvoviridae and evidence for inter- and intra-host genetic diversity and recombination, Journal of General Virology. 2011, 92: 2047-2059. |
| Lau S.K.P., Poon R.W.S., Wong B.H.L., Wang M., Huang Y., Xu H., Guo R., Li K.S.M., Guo K., Chan K.H., Zheng B., Woo P.C.Y. and Yuen K.Y., Coexistence of different genotypes in the same bat and serological characterization of Rousettus bat coronavirus HKU9 belonging to a novel Betacoronavirus subgroup. , J Virol. 2010, 84(21):: 11358-94. |
| Lee S.L., Chiu S.S.S., Peiris J.S.M., Chan K.H., Wong W.H.S. and Lau Y.L., Is respiratory viral infection really an important trigger of asthma exacerbations in children?, Eur J Pediatr [Epub ahead]. 2011. |
| Mak W.Y., Wong K.S.C., Li O.T.W., Chan K.H., Cheung C.L., Ma S.K., Webby R.I.C.H.A.R.D., Guan Y., Peiris J.S.M. and Poon L.L.M., Rapid genotyping of swine influenza viruses., Emerg Infect Dis.. 2011, 17: 691-694. |
| Ng S., Cheng K.Y., Lim Wai W.S., Fang J., Chan K.H., Ma S.K., Ip D.K.M., Chiu S.S.S., Peiris J.S.M., Leung G.M. and Cowling B.J., Seasonal influenza vaccine and risk of pandemic influenza infection: Findings from a randomized controlled trial (abstract and poster presentation), HKCCM International Conference, 4-6 September 2010, Hong Kong. Hong Kong, Hong Kong College of Community Medicine, 2010, 69. |
| Ning J., Xu X., Chan K.H. and Chiang A.K.S., Long-term carriers generate Epstein–Barr virus (EBV)-specific CD4+ and CD8+ polyfunctional T-cell responses which show immunodominance hierarchies of EBV proteins, Immunology. 2011, 134: 161-171. |
| To K.K.W., Wong S.S.Y., Li W.S., Hung I.F.N., Tse H., Woo P.C.Y., Chan K.H. and Yuen K.Y., Concurrent comparison of epidemiology, clinical presentation and outcome between adult patients suffering from the pandemic influenza A (H1N1) 2009 virus and seasonal influenza A virus infection, Postgrad Med J. 2010. |
| Wong C.M., Yang L., Chan K.P., Ma S.S.L., He J.F., Chen P.Y., Chan K.H. and Peiris J.S.M., Disease burden of influenza in three tropic and sub-tropic cities in Asia (abstract), Options for the Control of Influenza VII Conference, 3-7 September 2010, Hong Kong. Hong Kong, Int’l Society for Influenza & Other Respiratory Virus Dis, 2010, 229-230. |
| Yang L., Chiu S.S.S., Chan K.P., Chan K.H., Wong W.H.S., Peiris J.S.M. and Wong C.M., Validation of statistical models for estimating hospitalization associated with influenza and other respiratory viruses, PLoS One. 2011, 6(3): e17882. |
| Zheng B., Chan K.H., Zhang J., Zhou J., Chan C.S., Poon K.M., Zhang K., Leung H.C., Jin D., Woo P.C.Y., Chan J.F.W., To K.K.W., Chen H. and Yuen K.Y., D225G mutation in haemagglutinin of pandemic Influenza H1N1 (2009) virus enhances virulence in mice, Experimental Biology and Medicine. 2010, 235: 981-8. |
| Researcher : Chan MCW |
| Project Title: | Tissue tropism and innate immune responses of respiratory viruses in primary differentiated human respiratory epithelial cells in vitro and in ex-vivo cultures of lung and nasopharynx |
| Investigator(s): | Chan MCW, Nicholls JM, Poon LLM, Tsao GSW |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2008 |
| Completion Date: | 11/2010 |
| Project Title: | Effect of vitamin B2 in the treatment of human influenza H5N1 virus infection: studies in vitro and in vivo |
| Investigator(s): | Chan MCW, Peiris JSM, Chan WY |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 02/2009 |
| Project Title: | Role of Toll-like receptors and MyD88 in the innate immune response elicited by highly pathogenic influenza A (H5N1) virus infection in vivo |
| Investigator(s): | Chan MCW |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2009 |
| Completion Date: | 03/2011 |
| Project Title: | Influenza A (H5N1) virus infection in human primary type I and type II alveolar epithelial cells: Cell tropism, inflammatory responses and apoptosis |
| Investigator(s): | Chan MCW, Peiris JSM |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2010 |
| Project Title: | Effect of allogeneic human mesenchymal stem cells on alveolar fluid clearance and protein permeability in human alveolar epithelial cells injured by influenza H5N1 virus infection |
| Investigator(s): | Chan MCW, Nicholls JM |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2010 |
| Project Title: | Experimental models to study the impact of cigarette smoking on the tropism of the highly pathogenic avian influenza H5N1 virus in human respiratory tract |
| Investigator(s): | Chan MCW, Chan WY, Nicholls JM, Mak JCW |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 02/2011 |
| Project Title: | Tropism and innate host responses in primary human cardiac myocytes infected with influenza H5N1 and H1N1pdm virus |
| Investigator(s): | Chan MCW |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2011 |
| List of Research Outputs |
| Chan M.C.W., Chan W.Y., Yen H., Yu C.L., Yuen K.M., Tang L.L.S., Li C.L., Kang S.R., Hui F.F., Lai W.W.K., Sihoe A.D.L., Guan Y., Nicholls J.M. and Peiris J.S.M., ) Tropism and innate host response of the 2009 pandemic H1N1 influenza virus compared with related swine influenza viruses and reassortants in ex vivo and in vitro cultures of the human respiratory tract and conjunctiva, Options for the Control of Influenza VII, 2010. |
| Chan M.C.W., Chan W.Y., Yen H., Lee M.Y., Guan Y., Nicholls J.M. and Peiris J.S.M., Comparing the tropism of the pandemic H1N1/2009 influenza virus with seasonal influenza virus, related swine influenza viruses and reassortants in ex vivo and in vitro cultures of human conjunctiva and respiratory tract., 4th Annual Center of Excellence for Influenza Research and Surveillance Network Meeting, Woodcliff Hotel and Conference Center 199 Woodcliff Drive, Fairport, NY 14450 . 2010. |
| Chan M.C.W., Chan W.Y., Lee J.W., Fang X., Matthay M.A. and Peiris J.S.M., Impaired alveolar edema fluid clearance in human alveolar epithelial cells injured by severe influenza A virus infection, Keystone Symposia 2011 - Pathogenesis of influenza: virus-host interaction. 2011. |
| Chan M.C.W., Chan W.Y., Lee M.Y., Cheung C.Y., Nicholls J.M. and Peiris J.S.M., Pathogenesis of swine-origin influenza H1N1 virus (S-OIV) in humans: studies of viral tropism and host response in primary differentiated human respiratory epithelial cell cultures in vitro and in ex vivo, Health Research Symposium 2010. |
| Chan M.C.W., Chan W.Y., Yen H., Yu C.L., Yuen K.M., Tang L.L.S., Li C.L., Kang S.R., Hui F.F., Lai W.W.K., Sihoe A.D.L., Guan Y., Nicholls J.M. and Peiris J.S.M., Tropism and innate host response of the 2009 pandemic H2N2 influenza virus compared with related swine influenza viruses and reassortants in ex vivo and in vitro cultures of the human respiratory tract and conjunctiva, Influenza and other respiratory viruses. 2011, 5 (S1): 54-55. |
| Chan W.Y., Kang S.R., Yu C.L. and Chan M.C.W., Effect of vitamin B2 in the treatment of human influenza H5N1 virus infection: studies in vitro and in vivo. , Health Research Symposium 2010. |
| Chan W.Y., Chan M.C.W., Li S.Y., Nicholls J.M. and Peiris J.S.M., Neutrophil extracellular trap formation in acute influenza virus infection, Keystone Symposia 2011 - Pathogenesis of influenza: virus-host interaction, 2011 . 2011. |
| Chan W.Y., Hui F.F., Kang S.R., Yu C.L., Nicholls J.M. and Chan M.C.W., Replication and innate host response of influenza A virus in human lung microvascular endothelial cells: insights into systemic dissemination and pathogenesis , Options for the Control of Influenza VII. 2010. |
| Chan W.Y., Yuen K.M., Yu C.L., Tang L.L.S., Li C.L., Nicholls J.M. and Chan M.C.W., Replication of avian and seasonal influenza viruses in human bronchus and lung, Influenza and other respiratory viruses. 2011, 5: 425-426. |
| Chan W.Y., Chan M.C.W., Nicholls J.M. and Peiris J.S.M., Replication of avian and seasonal influenza viruses in human bronchus and lung, Options for the Control of Influenza VII. 2010. |
| Hui F.F., Chan W.Y., Fung K.H.Y., Yu C.L., Tsao G.S.W., Chan M.C.W. and Nicholls J.M., The regional distribution of different types of influenza receptors in cultured human alveolar epithelial cells and correlation with in vitro infection, Influenza and other respiratory viruses. 2011, 5(S1): 436-437. |
| Hui F.F., Chan W.Y., Fung K.H.Y., Yu C.L., Tsao G.S.W., Chan M.C.W. and Nicholls J.M., The regional distribution of different types of influenza receptors in cultured human alveolar epithelial cells and correlation with in vitro infection, Influenza and other respiratory viruses. 2011, 5(S1): 436-437. |
| Hui F.F., Chan W.Y., Fung K.H.Y., Yu C.L., Tsao G.S.W., Chan M.C.W. and Nicholls J.M., The regional distribution of different types of influenza receptors in cultured human alveolar epithelial cells and correlation with in vitro infection, Options for the Control of Influenza VII. 2010. |
| Jia D., Rahbar R., Chan W.Y., Lee M.Y., Chan M.C.W., Wang B.X., Baker D.P., Sun B., Peiris J.S.M., Nicholls J.M. and Fish E.N., Influenza virus non-structural protein 1 (NS1) disrupts interferon signaling. , PLoS One. 2010, 5 (11): e13927. |
| Lee M.Y., Chan W.Y., Gardy D.L., Lo C.K., Sihoe A.D.L., Kang S.R., Cheung K.W., Guan Y., Chan M.C.W., Hancock R.E. and Peiris J.S.M., Systems-level comparison of host responses induced by pandemic and seasonal influenza A H1N1 viruses in primary human type I-like alveolar epithelial cells in vitro, Respiratory Research. 2010, 11: 147. |
| Leung C.Y.H., Nicholls J.M., Sia S.F., Hui P.Y., Cheung P.P.H., Chow C.K., Chan W.Y., Chan M.C.W. and Peiris J.S.M., Toll-like Receptor 3 signaling contributes to enhanced disease severity in H5N1 but not pandemic H1N1 infection in mice, Keystone Symposia on Molecular and Cellular Biology: Pathogenesis of Influenza: virus-host interactions. 2011. |
| Li C.L., Chan W.Y., Hui F.F., Kang S.R., Yu C.L., Nicholls J.M. and Chan M.C.W., Replication and innate host response of influenza A virus in lung microvascular endothelial cells: new insights into systemic infection and pathogenesis, Influenza and other respiratory viruses. 2011, 5 (S1): 287-288. |
| Peiris J.S.M., Chan M.C.W., Chan W.Y. and Nicholls J.M., Human ex vivo and in vitro Experimental Models for Studying Influenza Pathogenesis, Keystone Symposia on Molecular and Cellular Biology: Pathogenesis of Influenza: virus-host interactions. 2011. |
| Yen H., Liang C., Wu C., Forrest H., Ferguson A., Choy K.T., Jones J., Wong D.D.Y., Cheung P.H.P., Hsu C., Li O.T.W., Yuen K.M., Chan W.Y., Poon L.L.M., Chan M.C.W., Nicholls J.M., Krauss S., Wong C.H., Guan Y., Webster R.G., Webby R. and Peiris J.S.M., Hemagglutinin-neuraminidase balance confers respiratory droplet transmissibility of the pandemic H1N1 influenza virus in ferrets, Keystone Symposia (Pathogenesis of Influenza: Virus-Host Interactions), May 23-28, 2011, Hong Kong SAR. 2011. |
| Yu C.L., Chan W.Y., Wang J., Nicholls J.M., Peiris J.S.M., Mason R.J. and Chan M.C.W., Avian influenza H5N1 and seasonal H1N1 virus infection and innate host responses in human alveolar type II epithelial cells and macrophages, Options for the Control of Influenza VII. 2010. |
| Yuen K.M., Chan W.Y., Mok K.P., Wong A.C.N., Kang S.R., Nicholls J.M. and Chan M.C.W., Differential onset of apoptosis in avian influenza H5N1 and seasonal H1N1 virus infected human bronchial and alveolar epithelial cell, an in vitro and ex vivo study, Options for the Control of Influenza VII. 2010. |
| Yuen K.M., Chan W.Y., Mok K.P., Wong C.N., Kang S.R., Nicholls J.M. and Chan M.C.W., Differential onset of apoptosis in avian influenza H5N1 and seasonal H1N1 virus infected human bronchial and alveolar epithelial cells: an in vitro and ex vivo study, Influenza and other respiratory viruses. 2011, 5 (S1): 437-438. |
| Researcher : Chen H |
| Project Title: | Modification of cells for isolation and characterization of SARS CoV from animal sources |
| Investigator(s): | Chen H |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Funding for New Staff |
| Start Date: | 07/2004 |
| Project Title: | Biological function/relevance for the 29 nucleotides insertion in the genome of animal SARS like CoV |
| Investigator(s): | Chen H, Guan Y |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2004 |
| Project Title: | Antiviral drug resistance in H5N1 virus |
| Investigator(s): | Chen H, Guan Y |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 01/2007 |
| Project Title: | Molecular basis for the regulation of influenza virus by nuclear factor NF90 |
| Investigator(s): | Chen H |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2011 |
| List of Research Outputs |
| Chan K.C., Ko J.M.Y., Lung H.L., Sedlacek R., Zhang Z.F., Luo D.Z., Feng Z.B., Chen S., Chen H., Chan K.W., Tsao G.S.W., Chua D.T.T., Zabarovsky E.R., Stanbridge E.J. and Lung M.L., Catalytic activity of matrix metalloproteinase-19 is essential for tumor suppressor and anti-angiogenic activities in nasopharyngeal carcinoma, International Journal of Cancer. 2010. |
| Chan K.H., To K.K.W., Hung I.F.N., Zhang J., Chan J.F.W., Cheng V.C.C., Tse H., Che X.Y., Chen H. and Yuen K.Y., Differences in antibody responses of individuals with natural infection and those vaccinated against pandemic H1N1 2009 influenza., Clinical Vaccine Immunology. 2011, 18: 867-73. |
| Chan K.H., Zhang J., To K.K.W., Chan C.S., Poon K.M., Guo K., Ng F., Zhang Q., Leung H.C., Cheung A.N.Y., Lau C.Y., Woo P.C.Y., Tse H., Wu W.L., Chen H., Zheng B. and Yuen K.Y., Wild type and mutant 2009 pandemic influenza A (H1N1) viruses cause more severe disease and higher mortality in pregnant BALB/c mice, PLoS One. 2010, 5: e13757. |
| Chen H., Host factors interacting with NS1 of influenza virus, Options for control of influenza VII, Sept 3-7, Hong Kong. 2010. |
| Chen H., NS1 regulates influenza virus replication through interaction with a cellular P-body component and viral NP protein, Keystone Symposium on Molecular and Cellular Biology/Pathogenesis of Influenza: Virus-Host Interaction, May 23-28, in Sheraton Hong Kong Hotel & Tower.. 2011. |
| Chen H., Regulation of Influenza Virus replication by nuclear factor , NF90, 2010 International Symposium on RNA Viruses, Dec 3-4, Chang Gung University, Taoyuan, Taiwan. 2010. |
| Cheng V.C.C., Chan J.F.W., Wen X., Wu W.L., Que T.L., Chen H., Chan K.H. and Yuen K.Y., Infection of immunocompromised patients by avian H9N2 influenza A virus, J Infect.. 2011, 62: 394-9. |
| Chu Y.C., Cheung C.L., Leung C.Y.H., Poon L.L.M., Chen H., Peiris J.S.M. and Guan Y., Continuing Evolution Of H9n2 Influenza Viruses Endemic In Poultry In Southern China, In: JSM Peiris & Y Guan, Options For The Control of Influenza VII. Oxford, UK, Wiley-Blackwell, 2011, 5 Suppl 1: 68-71. |
| Chu Y.C., Cheung C.L., Leung C.Y.H., Poon L.L.M., Chen H., Peiris J.S.M. and Guan Y., Continuing evolution of H9N2 influenza viruses endemic in poultry in southern China, Influenza Other Respi Viruses. 2011, 5: 68-71. |
| Danesh A., Cameron C.M., Leon A.J., Ran L., Xu L., Fang Y., Kelvin A.A., Rowe T., Chen H., Guan Y., Jonsson C.B., Cameron M.J. and Kelvin D.J., Early gene expression events in ferrets in response to SARS coronavirus infection versus direct interferon-alpha2b stimulation, Virology. 2011, 409(1): 102-12. |
| Dhanasekaran V., Smith G.J., Pybus O.G., Zhu H., Bahl J., Poon L.L.M., Riley S., Bahl J., Ma S.K., Cheung C.L., Perera R.A.P.M., Chen H., Shortridge K.F., Webby R., Guan Y. and Peiris J.S.M., Long-term evolution and transmission dynamics of swine influenza A virus., Nature. 2011, 473: 519-22. |
| Duan L., Zhu H., Wang J., Huang K., Cheung C.L., Peiris J.S.M., Chen H. and Guan Y., Influenza virus surveillance in migratory ducks and sentinel ducks at Poyang Lake, China., Influenza Other Respi Viruses. . 2011, Suppl 1: 65-68. |
| Duan L., Zhu H., Huang K., Wang J., Cheung C.L., Peiris J.S.M., Chen H. and Guan Y., Influenza virus surveillance in migratory ducks and sentinel ducks at Poyang Lake, China., Options for the Control of Influenza VII. 2010. |
| Huang K., Bahl J., Fan X... .H..., Dhanasekaran V., Cheung C.L., Webby R... .J..., Webster R... .G..., Chen H., Smith G.J., Peiris J.S.M. and Guan Y., Establishment of an H6N2 Influenza Virus Lineage in Domestic Ducks in Southern China., J Virol. 2010, 84: 6978-86. |
| Huang K., Cheung C.L., Fan X., Zhu H., Wang J., Duan L., Webby R., Webster R., Chen H., Peiris J.S.M. and Guan Y., Interspecies transmission and lineage replacement of H6 subtype influenza viruses in Southern China. , Options for the Control of Influenza VII. 2010. |
| Hung I.F.N., To K.K.W., Lee C.K., Lin C.K., Chan J.F.W., Tse H., Cheng V.C.C., Chen H., Ho P.L., Tse C.W., Ng T.K., Que T.L., Chan K.H. and Yuen K.Y., Effect of Clinical and Virological Parameters on the Level of Neutralizing Antibody against Pandemic Influenza A Virus H1N1 2009, Clin Infect Dis.. 2010, 51: 274-9. |
| Hung I.F.N., To K.K.W., Lee C.K., Lin C.K., Chan J.F.W., Tse H., Cheng V.C.C., Chen H., Ho P.L., Tse C.W.S., Ng T.K., Que T.L., Chan K.H. and Yuen K.Y., Effect of clinical and virological parameters on the level of neutralizing antibody against pandemic influenza A virus H1N1 2009., Clinical Infectious Disease. 2010, 51: 274-9. |
| Lin S., Liu N., Yang Z., Song W., Wang P., Chen H., Lucio M., Schmitt-Kopplin P., Chen G. and Cai Z., GC/MS-based metabolomics reveals fatty acid biosynthesis and cholesterol metabolism in cell lines infected with influenza A virus, Talanta. 2010, 83: 262-8. |
| Wong V.C., Chen H., Ko J.M.Y., Chan K.W., Chan Y.P., Law S.Y.K., Chua D.T.T., Kwong D.L.W., Lung H.L., Srivastava G., Tang J.C., Tsao G.S.W., Zabarovsky E.R., Stanbridge E.J. and Lung M.L., Tumor suppressor dual-specificity phosphatase 6 (DUSP6) impairs cell invasion and epithelial-mesenchymal transition (EMT)-associated phenotype, International journal of cancer. . 2011. |
| Yuan Q., Cheng X.D., Yang B.C., Zheng Q.B., Chen Y.X., Chen Q.R., Zeng F., Zhang R., Ge S.X., Hao X.K., Chen H., Zhang J. and Xia N.S., Differential diagnosis of pandemic (H1N1) 2009 infection by detection of haemagglutinin with an enzyme-linked immunoassay, Clin Microbiol Infect. 2011, 17: 1574-80. |
| Zheng B., Chan K.H., Zhang J., Zhou J., Chan C.S., Poon K.M., Zhang K., Leung H.C., Jin D., Woo P.C.Y., Chan J.F.W., To K.K.W., Chen H. and Yuen K.Y., D225G mutation in haemagglutinin of pandemic Influenza H1N1 (2009) virus enhances virulence in mice, Experimental Biology and Medicine. 2010, 235: 981-8. |
| Zheng Q., Xia L., Wu W.L., Zheng Z., Huo Y., Wu J., Liu Y., Yu H., Chen Y., Lau S.Y., Chen H., Luo W. and Xia N., Properties and therapeutic efficacy of broadly reactive chimeric and humanized H5-specific monoclonal antibodies against H5N1 influenza viruses, Antimicrobial Agents and Chemotherapy. 2011, 55: 1349-57. |
| Zhu H., Wang J., Chen H., Webster R., Webby R., Peiris J.S.M. and Guan Y., Influenza surveillance program in swine in Southern China (Dec 2009-Jun 2010), National Institute of Allergy and Infectious Diseases 4th Annual CEIRS Network Meeting. 2010. |
| Zhu H., Wang J., Zheng Z., Li L., Duan L., Yip C.H., Peiris J.S.M., Chen H. and Guan Y., Pathogenicity and transmissibility of the pandemic (H1N1) 2009-related influenza viruses in pigs and mice., Options for the Control of Influenza VII. 2010. |
| Zhu H., Wang J., Zheng Z., Chen R., Zheng R., Li L., Duan L., Zhang T., Yip C.H., Yan Z., Chen H., Peiris J.S.M. and Guan Y., Pathogenicity and transmissibility of the pandemic H1N1 2009-related influenza viruses in mice, ferrets, and pigs., Influenza Other Respi Viruses.. 2011, Suppl 1: 82-84. |
| Zhu H., Smith D.K., Lam T.Y., Li L., Zheng Z., Chen R., Zheng R., Zeng Y., Zhou J., Wang J., Chen H., Webster R.G., Webby R., Peiris J.S.M. and Guan Y., Reassortants of the pandemic H1N1/2009 virus in swine and their potential to infect human., National Institute of Allergy and Infectious Diseases 5th Annual CEIRS Network Meeting. 2011. |
| Zhu H., Wang J., Wang P., Song W., Zheng Z., Chen R., Guo K., Zhang T., Duan L., Li L., Yip C.H., Peiris J.S.M., Chen H. and Guan Y., Substitution of E627K in PB2 protein does not change virulence of the 2009 pandemic H1N1 virus in mice., Options for the Control of Influenza VII. 2010. |
| Researcher : Chen JHK |
| Project Title: | Molecular epidemiology study of HIV-1 among the men who have sex with men (MSM) population in Hong Kong |
| Investigator(s): | Chen JHK, Yam WC |
| Department: | Microbiology |
| Source(s) of Funding: | Council for the AIDS Trust Fund - General Award |
| Start Date: | 04/2009 |
| Researcher : Chen M |
| Project Title: | Immunogenicity and Cross-Protective Effect of Novel human T cell Epitopes in H5N1 influenza virus nucleoprotein |
| Investigator(s): | Chen M, Zheng B |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 10/2010 |
| List of Research Outputs |
| Cao T., Chen M. and Zheng B., Ientification and Evaluation of Protective Ability of a T Cell Epitope Targeting Nucleoprotein of H5N1 influenza virus. , 1st European Conference of Microbiology and Immunology.. Budapest, Hungary., 2011. |
| Du L., Leung H.C., Zhang X., Zhou J., Chen M., He W., Zhang H., Chan C.S., Poon K.M., Zhao G., Sun S., Cai L., Zhou Y., Zheng B. and Jiang S., A recombinant vaccine of H5N1 HA1 fused with foldon and human IgG Fc induced complete cross-clade protection against divergent H5N1 viruses., PloS One. 2011, 6(1):: e16555. |
| Liu S., Li R., Zhang R., Chan C.S., Xi B., Zhu Z., Yang J., Poon K.M., Zhou J., Chen M., Munch J., Kirchhoff F., Pleschka S., Haarmann T., Dietrich U., Pan C., Du L., Jiang S. and Zheng B., CL-385319 inhibits H5N1 avian influenza A virus infection by blocking viral entry. , Eur J Pharmacol . 2011, 660:: 460-467. |
| Tang S.F., Chan J.F.W., Chen M., Tsang O.T.Y., Mok M.Y., Lai W.Y.M., Lee R.A., Que T.L., Tse H., Li W.S., To K.K.W., Cheng V.C.C., Chan E., Zheng B. and Yuen K.Y., Disseminated penicilliosis, recurrent bacteremic non-typhoidal salmonellosis and burkholderiosis associated with acquired immunodeficiency due to autoantibody against interferon gamma., Clin Vaccine Immunol. 2010, 17(7):: 1132-1138. |
| Zhang N., Lin Y., Chen M., Zhang Q., Cao T. and Zheng B., Swine-Origin Influenza Virus Like Particle Vaccine Conferred Complete Protection Against Lethal Viral Challenge in Balb/C Mice., 1st European Conference of Microbiology and Immunology.. Budapest, Hungary., 2011. |
| Zhao G., Lin Y., Du L., Guan J., He Y., Sun S., Xiao W., Chen M., Chan C.S., Kou Z., Lustigman S., Jiang S., Zheng B. and Zhou Y., Induction of protection against divergent H5N1 influenza viruses using a recombinant fusion protein linking influenza M2e to Onchocerca volvulus activation associated protein-1 (ASP-1) adjuvant., Vaccine. 2010, 28(44):: 7233-40. |
| Researcher : Chen Z |
| Project Title: | A novel model for the study of lung pathogenesis of SARS |
| Investigator(s): | Chen Z |
| Department: | Medical Faculty |
| Source(s) of Funding: | National Institutes of Health, US Department of Health and Human Services - General Award |
| Start Date: | 08/2007 |
| Project Title: | Understanding the Ongoing HIV Epidemic in Yunnan China |
| Investigator(s): | Chen Z |
| Department: | Medical Faculty |
| Source(s) of Funding: | China AIDS Initiative - General Award |
| Start Date: | 05/2008 |
| Project Title: | Preventing HIV-1 infection using a novel vaccine immunogen |
| Investigator(s): | Chen Z |
| Department: | Medical Faculty |
| Source(s) of Funding: | Global Health Grants |
| Start Date: | 10/2008 |
| Project Title: | Role of the PD-1/PD-L pathway in HIV DNA vaccine design |
| Investigator(s): | Chen Z |
| Department: | Medical Faculty |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2009 |
| Completion Date: | 12/2010 |
| Project Title: | Role of the PD-1/PD-L pathway in HIV-1 vaccine design |
| Investigator(s): | Chen Z |
| Department: | Medical Faculty |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2009 |
| Project Title: | Characterization of novel anti-HIV/TB natural product analogues |
| Investigator(s): | Chen Z |
| Department: | Medical Faculty |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 03/2010 |
| Project Title: | BIT’s 1st World Congress of Virus and Infections 2010 (WCVI 2010) An effective mucosal vaccination regimen to protect AIDS viral infection |
| Investigator(s): | Chen Z |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 07/2010 |
| Completion Date: | 08/2010 |
| Project Title: | Investigation of HIV-1 new outbreaks in Fujian, China |
| Investigator(s): | Chen Z |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 10/2010 |
| Project Title: | Blocking HIV infection by gene-encoding neutralizing antibodies |
| Investigator(s): | Chen Z |
| Department: | Microbiology |
| Source(s) of Funding: | Travel Grants for NSFC/RGC JRS |
| Start Date: | 12/2010 |
| Project Title: | Establishment of a rapid, high-throughput, cost-effective HIV-1 drug resistance testing system |
| Investigator(s): | Chen Z |
| Department: | Microbiology |
| Source(s) of Funding: | Council for the AIDS Trust Fund - General Award |
| Start Date: | 05/2011 |
| List of Research Outputs |
| Chen Z., 17th Society on NeuroImmune Pharmacology (SNIP) Conference, Role: Has been invited to present at the conference and was appointed to be a council member of the American Society on NeuroImmune Pharmacology. 2011. |
| Chen Z., BIT’s 1st World Congress of Virus and Infections 2010. Busan, South Korea , Role: SAB member and section Chairman . 2010. |
| Chen Z., Certificate of Appreciation for effort to the abstract reviewing for the XVIII International AIDS Conference, July 2010, Vienna, Austria. , The AIDS 2010 Scientific Programme Committee. 2010. |
| Chen Z., Clinical Infectious Diseases Award for Outstanding Review (fewer than 5% of all reviews receive this designation), The Clinical Infectious Diseases (CID). 2010. |
| Chen Z., Fourth Ditan International Conference on Infectious Diseases. Beijing, China.. 2010. |
| Chen Z., The 4th International Symposium on Emerging Viral Diseases. Wuhan, China.. 2010. |
| Chen Z., The development of an AIDS mucosal vaccine, The Scientific Meeting of the Institut Pasteur International Network” at The University of Hong Kong. 2010. |
| Chen Z., The fifth China Health communication Conference and Tsinghua public health science conference” at Tsinghua University in Beijing. 2010. |
| Chen Z., Transgenic Plasmodium that expresses HIV-1 Gag elicits immunity and protects mice against vaccinia virus-gag and malarial parasites., In: Jiang B, Qin L, Du Y, Peng N, Chen L, Chen Z, Chen X., Vaccine. 2010, 28(50): 7915-22. |
| Chen Z., 解密沙士(SARS)病毒传播的新机制, Tsinghua-Yue-Yuen Symposium on Medical Sciences 2011”at Tsinghua University. 2011. |
| Liu L., Wei Q., Alvarez X., Wang H., Du Y., Zhu H., Jiang H., Zhou J., Lam P., Zhang L., Lackner A., Qin C. and Chen Z., Epithelial Cells Lining Salivary Gland Ducts Are Early Target Cells of Severe Acute Respiratory Syndrome Coronavirus Infection in the Upper Respiratory Tract of Rhesus Macaques, J Virol. 2011, 85(8): 4025-30. |
| Lu B., Yu W., Huang X., Wang H., Liu L. and Chen Z., Mucosal Immunization Induces a Higher Level of Lasting Neutralizing Antibody Response in Mice by a Replication-Competent Smallpox Vaccine: Vaccinia Tiantan Stain., Journal of Biomedicine and Biotechnology. 2011, 2011:: 970424. |
| Wang H., Zhuang K., Liu L., Tang Z., Tang J., Tien P., Zhang L. and Chen Z., Acute Infection of Chinese Macaques by a CCR5-Tropic SHIV Carrying a Primary HIV-1 Subtype B' Envelope., J Acquir Immune Defic Syndr. 2011, 53: 285-291. |
| Researcher : Cheng VCC |
| List of Research Outputs |
| Chan J.F.W., Hwang G.Y., Lamb S., Chan G.S.W., So J.C.C., Leung S.S., To K.K.W., Li W.S., Cheng V.C.C. and Yuen K.Y., Pneumococcal native aortic valve endocarditis with mycotic abdominal aortic aneurysm, paraspinal and iliopsoas abscesses and pneumonia revealing a multiple myeloma, J Med Microbiol. 2011, 60(Pt 6): 851-5. |
| Chan J.F.W., To K.K.W., Tse H., Lau C.Y., Li W.S., Hung I.F.N., Chan K.H., Cheng V.C.C., Lai T.S.T., Woo P.C.Y., Chan E.Y.T. and Yuen K.Y., The lower serum immunoglobulin G2 level in severe cases than in mild cases of pandemic H1N1 2009 influenza is associated with cytokine dysregulation, Clinical and Vaccine Immunology. 2010, 18: 305-310. |
| Chan K.H., To K.K.W., Hung I.F.N., Zhang J., Chan J.F.W., Cheng V.C.C., Tse H., Che X.Y., Chen H. and Yuen K.Y., Differences in antibody responses of individuals with natural infection and those vaccinated against pandemic H1N1 2009 influenza., Clinical Vaccine Immunology. 2011, 18: 867-73. |
| Chen J.H.K., Wong K.H., Chen Z., Chan K.C.W., Lam H.Y., To W.C.S., Cheng V.C.C., Yuen K.Y. and Yam W.C., Increased Genetic Diversity of HIV-1 Circulating in Hong Kong, In: Vlsdimir N., PLoS One. 2010, 5: e12198. |
| Cheng V.C.C., Chan J.F.W., Wen X., Wu W.L., Que T.L., Chen H., Chan K.H. and Yuen K.Y., Infection of immunocompromised patients by avian H9N2 influenza A virus, J Infect.. 2011, 62: 394-9. |
| Cheng V.C.C., Wong L.M., Tai J.W., Chan J.F.W., To K.K.W., Li W.S., Hung I.F.N., Chan K.H., Ho P.L. and Yuen K.Y., Prevention of nosocomial transmission of norovirus by strategic infection control measures, Infection control and hospital epidemiology. 2011, 32(3): 229-37. |
| Cheng V.C.C., Tai J.W.M., Chan W.M., Lau E.H.Y., Chan J.F.W., To K.K.W., Li W.S., Ho P.L. and Yuen K.Y., Sequential introduction of single room isolation and hand hygiene campaign in the control of methicillin-resistant Staphylococcus aureus in intensive care unit., BMC infectious diseases. 2010, 10: 263. |
| Cheng V.C.C., Chan J.F.W., Lau E.H.Y., Yam W.C., Ho S.K.Y., Yau M.C.Y., Tse E.Y.F., Wong A.C.Y., Tai J.W.M., Fan S.T., Ho P.L. and Yuen K.Y., Studying the transmission dynamics of meticillin-resistant Staphylococcus aureus in Hong Kong using spa typing, Journal of Hospital Infection. 2011, 79(3): 206-210. |
| Hung I.F.N., To K.K.W., Lee C.K., Lin C.K., Chan J.F.W., Tse H., Cheng V.C.C., Chen H., Ho P.L., Tse C.W., Ng T.K., Que T.L., Chan K.H. and Yuen K.Y., Effect of Clinical and Virological Parameters on the Level of Neutralizing Antibody against Pandemic Influenza A Virus H1N1 2009, Clin Infect Dis.. 2010, 51: 274-9. |
| Hung I.F.N., To K.K.W., Lee C.K., Lin C.K., Chan J.F.W., Tse H., Cheng V.C.C., Chen H., Ho P.L., Tse C.W.S., Ng T.K., Que T.L., Chan K.H. and Yuen K.Y., Effect of clinical and virological parameters on the level of neutralizing antibody against pandemic influenza A virus H1N1 2009., Clinical Infectious Disease. 2010, 51: 274-9. |
| Tang S.F., Chan J.F.W., Chen M., Tsang O.T.Y., Mok M.Y., Lai W.Y.M., Lee R.A., Que T.L., Tse H., Li W.S., To K.K.W., Cheng V.C.C., Chan E., Zheng B. and Yuen K.Y., Disseminated penicilliosis, recurrent bacteremic non-typhoidal salmonellosis and burkholderiosis associated with acquired immunodeficiency due to autoantibody against interferon gamma., Clin Vaccine Immunol. 2010, 17(7):: 1132-1138. |
| To K.K.W., Cheng V.C.C., Chan J.F.W., Wong A.C., Chau S., Tsang F.H.F., Curreem S.O.T., Lau S.K.P., Yuen K.Y. and Woo P.C.Y., Molecular characterization of a catalase-negative Staphylococcus aureus subsp. aureus from a patient with mitral valve endocarditis and pericarditis revealed novel nonsense mutation in katA gene., Journal of Clinical Microbiology. 2011. |
| Researcher : Cheung CL |
| List of Research Outputs |
| Chu Y.C., Cheung C.L., Leung C.Y.H., Poon L.L.M., Chen H., Peiris J.S.M. and Guan Y., Continuing Evolution Of H9n2 Influenza Viruses Endemic In Poultry In Southern China, In: JSM Peiris & Y Guan, Options For The Control of Influenza VII. Oxford, UK, Wiley-Blackwell, 2011, 5 Suppl 1: 68-71. |
| Chu Y.C., Cheung C.L., Leung C.Y.H., Poon L.L.M., Chen H., Peiris J.S.M. and Guan Y., Continuing evolution of H9N2 influenza viruses endemic in poultry in southern China, Influenza Other Respi Viruses. 2011, 5: 68-71. |
| Dhanasekaran V., Smith G.J., Pybus O.G., Zhu H., Bahl J., Poon L.L.M., Riley S., Bahl J., Ma S.K., Cheung C.L., Perera R.A.P.M., Chen H., Shortridge K.F., Webby R., Guan Y. and Peiris J.S.M., Long-term evolution and transmission dynamics of swine influenza A virus., Nature. 2011, 473: 519-22. |
| Duan L., Zhu H., Wang J., Huang K., Cheung C.L., Peiris J.S.M., Chen H. and Guan Y., Influenza virus surveillance in migratory ducks and sentinel ducks at Poyang Lake, China., Influenza Other Respi Viruses. . 2011, Suppl 1: 65-68. |
| Duan L., Zhu H., Huang K., Wang J., Cheung C.L., Peiris J.S.M., Chen H. and Guan Y., Influenza virus surveillance in migratory ducks and sentinel ducks at Poyang Lake, China., Options for the Control of Influenza VII. 2010. |
| Huang K., Bahl J., Fan X... .H..., Dhanasekaran V., Cheung C.L., Webby R... .J..., Webster R... .G..., Chen H., Smith G.J., Peiris J.S.M. and Guan Y., Establishment of an H6N2 Influenza Virus Lineage in Domestic Ducks in Southern China., J Virol. 2010, 84: 6978-86. |
| Huang K., Cheung C.L., Fan X., Zhu H., Wang J., Duan L., Webby R., Webster R., Chen H., Peiris J.S.M. and Guan Y., Interspecies transmission and lineage replacement of H6 subtype influenza viruses in Southern China. , Options for the Control of Influenza VII. 2010. |
| Mak W.Y., Wong K.S.C., Li O.T.W., Chan K.H., Cheung C.L., Ma S.K., Webby R.I.C.H.A.R.D., Guan Y., Peiris J.S.M. and Poon L.L.M., Rapid genotyping of swine influenza viruses., Emerg Infect Dis.. 2011, 17: 691-694. |
| Researcher : Cheung CL |
| List of Research Outputs |
| Chu Y.C., Cheung C.L., Leung C.Y.H., Poon L.L.M., Chen H., Peiris J.S.M. and Guan Y., Continuing Evolution Of H9n2 Influenza Viruses Endemic In Poultry In Southern China, In: JSM Peiris & Y Guan, Options For The Control of Influenza VII. Oxford, UK, Wiley-Blackwell, 2011, 5 Suppl 1: 68-71. |
| Chu Y.C., Cheung C.L., Leung C.Y.H., Poon L.L.M., Chen H., Peiris J.S.M. and Guan Y., Continuing evolution of H9N2 influenza viruses endemic in poultry in southern China, Influenza Other Respi Viruses. 2011, 5: 68-71. |
| Dhanasekaran V., Smith G.J., Pybus O.G., Zhu H., Bahl J., Poon L.L.M., Riley S., Bahl J., Ma S.K., Cheung C.L., Perera R.A.P.M., Chen H., Shortridge K.F., Webby R., Guan Y. and Peiris J.S.M., Long-term evolution and transmission dynamics of swine influenza A virus., Nature. 2011, 473: 519-22. |
| Duan L., Zhu H., Wang J., Huang K., Cheung C.L., Peiris J.S.M., Chen H. and Guan Y., Influenza virus surveillance in migratory ducks and sentinel ducks at Poyang Lake, China., Influenza Other Respi Viruses. . 2011, Suppl 1: 65-68. |
| Duan L., Zhu H., Huang K., Wang J., Cheung C.L., Peiris J.S.M., Chen H. and Guan Y., Influenza virus surveillance in migratory ducks and sentinel ducks at Poyang Lake, China., Options for the Control of Influenza VII. 2010. |
| Huang K., Bahl J., Fan X... .H..., Dhanasekaran V., Cheung C.L., Webby R... .J..., Webster R... .G..., Chen H., Smith G.J., Peiris J.S.M. and Guan Y., Establishment of an H6N2 Influenza Virus Lineage in Domestic Ducks in Southern China., J Virol. 2010, 84: 6978-86. |
| Huang K., Cheung C.L., Fan X., Zhu H., Wang J., Duan L., Webby R., Webster R., Chen H., Peiris J.S.M. and Guan Y., Interspecies transmission and lineage replacement of H6 subtype influenza viruses in Southern China. , Options for the Control of Influenza VII. 2010. |
| Mak W.Y., Wong K.S.C., Li O.T.W., Chan K.H., Cheung C.L., Ma S.K., Webby R.I.C.H.A.R.D., Guan Y., Peiris J.S.M. and Poon L.L.M., Rapid genotyping of swine influenza viruses., Emerg Infect Dis.. 2011, 17: 691-694. |
| Researcher : Cheung CY |
| Project Title: | Determination of cellular receptors involved in differentially high pro-inflammatory induction by influenza A subtype H5N1 viruses in primary human monocyte-derived macrophages |
| Investigator(s): | Cheung CY |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2006 |
| Project Title: | Mechanism of action for the regulation of COX-2 dependent genes in human macrophages after infection with low and high pathogenic coronavirus and influenza viruses |
| Investigator(s): | Cheung CY, Lee MY |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2010 |
| List of Research Outputs |
| Chan M.C.W., Chan W.Y., Lee M.Y., Cheung C.Y., Nicholls J.M. and Peiris J.S.M., Pathogenesis of swine-origin influenza H1N1 virus (S-OIV) in humans: studies of viral tropism and host response in primary differentiated human respiratory epithelial cell cultures in vitro and in ex vivo, Health Research Symposium 2010. |
| Cheung C.Y., Leung C.K.L. and Peiris J.S.M., Potential of the real-time and label-free cell sensor impedance technology to transform cell based infectivity assays for influenza viruses, INFLUENZA AND OTHER RESPIRATORY VIRUSES. 2011, 5: 269-272. |
| Hui P.Y., Lee M.Y., Cheung C.Y., Peiris J.S.M. and Peiris J.S.M., The Role of Innate Sensing Receptors in H5N1 Associated Hyper-induction of Cytokines , Influenza and other respiratory viruses. Oxford, UK, Wiley-Blackwell, 2011, 5: 269-272. |
| Hui P.Y., Lee M.Y., Cheung C.Y., Peiris J.S.M. and Peiris J.S.M., The Role of Innate Sensing Receptors in H5N1 Associated Hyper-induction of Cytokines , Options for the Control of Influenza VII. 2010. |
| Hui P.Y., Lee M.Y., Cheung C.Y., Peiris J.S.M. and Peiris J.S.M., The Role of Innate Sensing Receptors in Highly Pathogenic Avian Influenza (HPAI) H5N1 Associated Hyper-induction of Cytokines, Keystone Symposia: Pathogenesis of Influenza: Virus-Host Interactions. Hong Kong SAR, China, 2011, 129. |
| Hui P.Y., Lee M.Y., Cheung C.Y. and Peiris J.S.M., The role of innate sensing receptors in H5N1 associated hyper-induction of cytokines, INFLUENZA AND OTHER RESPIRATORY VIRUSES. 2011, 5: 269-272. |
| Ma S.K., Ho P.L., Cheung C.Y., Tse T.M., Dhanasekaran V., Poon L.L.M., Guan Y. and Peiris J.S.M., Surveillance of influenza viruses in swine in Hong Kong abattoir: methods and feasibility, INFLUENZA AND OTHER RESPIRATORY VIRUSES. 2011, 5: 74-76. |
| Yip M.S., Cheung C.Y., Li P.H., Bruzzone R., Peiris J.S.M. and Jaume M.D.A., Investigation of Antibody-Dependent Enhancement (ADE) of SARS Coronavirus Infection and Its Role in Pathogenesis of SARS, International Network of Pasteur Institutes Annual Symposium. 2010. |
| Researcher : Cheung KW |
| List of Research Outputs |
| Lee M.Y., Gai W., Cheung K.W. and Peiris J.S.M., Antiviral activity of a selective COX-2 inhibitor NS-398 on avian influenza H5N1 infection, Influenza and other respiratory viruses. Wiley-Blackwell, 2011, 5(Suppl.1): 230-251. |
| Lee M.Y., Gai W., Cheung K.W. and Peiris J.S.M., Antiviral activity of a selective COX-2 inhibitor, NS-398 on avain influenza H5N1 infection., Options for the Control of Influenza VII, 2010. |
| Lee M.Y., Chan W.Y., Gardy D.L., Lo C.K., Sihoe A.D.L., Kang S.R., Cheung K.W., Guan Y., Chan M.C.W., Hancock R.E. and Peiris J.S.M., Systems-level comparison of host responses induced by pandemic and seasonal influenza A H1N1 viruses in primary human type I-like alveolar epithelial cells in vitro, Respiratory Research. 2010, 11: 147. |
| Ng Y.P., Lee M.Y., Cheung K.W., Nicholls J.M., Peiris J.S.M. and Ip N.Y., Avian influenza H5N1 virus induces cytopathy and proinflammatory cytokine responses in human astrocytic and neuronal cell lines, Neuroscience. 2010, 168(3): 613-23. |
| Researcher : Cheung PHP |
| List of Research Outputs |
| Leung C.Y.H., Cheung P.H.P., Zhang L., Wu Y.O., Chow K.C., Ho C.K., Chow C.K., Ng C.F., Tsang C.L., Dhanasekaran V., Smith G.J., Guan Y. and Peiris J.S.M., Influenza Viruses In Wild Birds In Hong Kong, 2003-2010, In: JSM Peiris & Y Guan, Options For The Control Of Influenza VII. Oxford, UK, Wiley-Blackwell, 2011, 5: 77-78. |
| Yen H., Liang C., Wu C., Forrest H., Ferguson A., Choy K.T., Jones J., Wong D.D.Y., Cheung P.H.P., Hsu C., Li O.T.W., Yuen K.M., Chan W.Y., Poon L.L.M., Chan M.C.W., Nicholls J.M., Krauss S., Wong C.H., Guan Y., Webster R.G., Webby R. and Peiris J.S.M., Hemagglutinin-neuraminidase balance confers respiratory droplet transmissibility of the pandemic H1N1 influenza virus in ferrets, Keystone Symposia (Pathogenesis of Influenza: Virus-Host Interactions), May 23-28, 2011, Hong Kong SAR. 2011. |
| Researcher : Cheung PPH |
| List of Research Outputs |
| Leung C.Y.H., Cheung P.P.H., Zhang L., Wu Y.O., Chow K.C., Ho C.K., Chow C.K., Ng C.F., Li C., Tsang C.L., Dhanasekaran V., Smith G.J., Guan Y. and Peiris J.S.M., Influenza viruses in wild birds in Hong Kong, 2003-2010 , Influenza Other Respi Viruses. 2011, 5: 77-78. |
| Leung C.Y.H., Nicholls J.M., Sia S.F., Hui P.Y., Cheung P.P.H., Chow C.K., Chan W.Y., Chan M.C.W. and Peiris J.S.M., Toll-like Receptor 3 signaling contributes to enhanced disease severity in H5N1 but not pandemic H1N1 infection in mice, Keystone Symposia on Molecular and Cellular Biology: Pathogenesis of Influenza: virus-host interactions. 2011. |
| Yen H., Forrest H., Cheung P.P.H., Wong D.D.Y., Li O.T.W., Krauss S., Ferguson A., Crumpton J.C., Jones J., Choy K.T., Ma S.K., Poon L.L.M., Smith G.J., Nicholls J.M., Guan Y., Webster R.G., Webby R. and Peiris J.S.M., Transmissibility of pandemic H1N1 and genetically related swine influenza viruses in ferrets, Influenza Other Respi Viruses. 2011, 5: 85-87. |
| Yen H., Forrest H., Cheung P.P.H., Wong D.D.Y., Li O.T.W., Krauss S., Ferguson A., Crumpton J.C., Jones J., Choy K.T., Ma S.K., Poon L.L.M., Smith G.J., Nicholls J.M., Guan Y., Webster R., Webby R. and Peiris J.S.M., Transmissibility of pandemic H1N1 and genetically related swine influenza viruses in ferrets, Options for the Control of Influenza VII, 2010, Hong Kong. 2010. |
| Researcher : Chin WH |
| List of Research Outputs |
| Chu K.W., Chin W.H., Smith G.J., Chan K.H., Guan Y., Peiris J.S.M. and Poon L.L.M., Detection of novel astroviruses in urban brown rats and previously known astroviruses in humans., J Gen Virol. . 2010, 91: 2457-2462. |
| Researcher : Choi KY |
| List of Research Outputs |
| Woo P.C.Y., Lau S.K.P., Lee P., Miao J., Fung A.M.Y., Choi K.Y., Ellis-Behnke R.G. and Yuen K.Y., Resequencing microarray for detection of human adenoviruses in patients with community-acquired gastroenteritis: a proof of concept study, Journal of Medical Microbiology. 2010, 59: 1387-1390. |
| Researcher : Chong TK |
| List of Research Outputs |
| Woo P.C.Y., Tam W.T., Chong T.K., Cai J.J., Tung T.K., Ngan H.Y., Lau S.K.P. and Yuen K.Y., High diversity of polyketide synthase genes and the melanin biosynthesis gene cluster in Penicillium marneffei, FEBS Journal. 2010, 277: 3750-3758. |
| Researcher : Chow CK |
| List of Research Outputs |
| Leung C.Y.H., Cheung P.H.P., Zhang L., Wu Y.O., Chow K.C., Ho C.K., Chow C.K., Ng C.F., Tsang C.L., Dhanasekaran V., Smith G.J., Guan Y. and Peiris J.S.M., Influenza Viruses In Wild Birds In Hong Kong, 2003-2010, In: JSM Peiris & Y Guan, Options For The Control Of Influenza VII. Oxford, UK, Wiley-Blackwell, 2011, 5: 77-78. |
| Leung C.Y.H., Cheung P.P.H., Zhang L., Wu Y.O., Chow K.C., Ho C.K., Chow C.K., Ng C.F., Li C., Tsang C.L., Dhanasekaran V., Smith G.J., Guan Y. and Peiris J.S.M., Influenza viruses in wild birds in Hong Kong, 2003-2010 , Influenza Other Respi Viruses. 2011, 5: 77-78. |
| Leung C.Y.H., Nicholls J.M., Sia S.F., Hui P.Y., Cheung P.P.H., Chow C.K., Chan W.Y., Chan M.C.W. and Peiris J.S.M., Toll-like Receptor 3 signaling contributes to enhanced disease severity in H5N1 but not pandemic H1N1 infection in mice, Keystone Symposia on Molecular and Cellular Biology: Pathogenesis of Influenza: virus-host interactions. 2011. |
| Researcher : Chow KC |
| List of Research Outputs |
| Leung C.Y.H., Cheung P.H.P., Zhang L., Wu Y.O., Chow K.C., Ho C.K., Chow C.K., Ng C.F., Tsang C.L., Dhanasekaran V., Smith G.J., Guan Y. and Peiris J.S.M., Influenza Viruses In Wild Birds In Hong Kong, 2003-2010, In: JSM Peiris & Y Guan, Options For The Control Of Influenza VII. Oxford, UK, Wiley-Blackwell, 2011, 5: 77-78. |
| Leung C.Y.H., Cheung P.P.H., Zhang L., Wu Y.O., Chow K.C., Ho C.K., Chow C.K., Ng C.F., Li C., Tsang C.L., Dhanasekaran V., Smith G.J., Guan Y. and Peiris J.S.M., Influenza viruses in wild birds in Hong Kong, 2003-2010 , Influenza Other Respi Viruses. 2011, 5: 77-78. |
| Researcher : Chow KH |
| List of Research Outputs |
| Ho P.L., Lo W.U., Yeung M.K., Lin C., Chow K.H., Ang L., Tong A.H.Y., Bao Y., Lok S. and Lo J.Y., Complete sequencing of pNDM-HK encoding NDM-1 carbapenemase from a multidrug-resistant Escherichia coli strain isolated in Hong Kong. , PLoS One. 2011, 6: e17989. |
| Ho P.L., Ang L., Chow K.H., Lai E.L.Y. and Chiu S.S.S., The prevalence and characteristics of Streptococcus pneumoniae isolates expressing serotypes 6C and 6D in Hong Kong prior to the introduction of the 7-valent pneumococcal conjugate vaccine , Diagnostic Microbiology and Infectious Disease. 2010. |
| Li C.B., Au K.Y., Fang J.W., Yim H.C.H., Chow K.H., Ho P.L. and Lau A.S.Y., HIV-1 trans-activator protein dysregulates IFN-γ signaling and contributes to the suppression of autophagy induction., AIDS. 2011, 25(1): 15-25. |
| Researcher : Choy KT |
| List of Research Outputs |
| Yen H., Liang C., Wu C., Forrest H., Ferguson A., Choy K.T., Jones J., Wong D.D.Y., Cheung P.H.P., Hsu C., Li O.T.W., Yuen K.M., Chan W.Y., Poon L.L.M., Chan M.C.W., Nicholls J.M., Krauss S., Wong C.H., Guan Y., Webster R.G., Webby R. and Peiris J.S.M., Hemagglutinin-neuraminidase balance confers respiratory droplet transmissibility of the pandemic H1N1 influenza virus in ferrets, Keystone Symposia (Pathogenesis of Influenza: Virus-Host Interactions), May 23-28, 2011, Hong Kong SAR. 2011. |
| Yen H., Forrest H., Cheung P.P.H., Wong D.D.Y., Li O.T.W., Krauss S., Ferguson A., Crumpton J.C., Jones J., Choy K.T., Ma S.K., Poon L.L.M., Smith G.J., Nicholls J.M., Guan Y., Webster R.G., Webby R. and Peiris J.S.M., Transmissibility of pandemic H1N1 and genetically related swine influenza viruses in ferrets, Influenza Other Respi Viruses. 2011, 5: 85-87. |
| Yen H., Forrest H., Cheung P.P.H., Wong D.D.Y., Li O.T.W., Krauss S., Ferguson A., Crumpton J.C., Jones J., Choy K.T., Ma S.K., Poon L.L.M., Smith G.J., Nicholls J.M., Guan Y., Webster R., Webby R. and Peiris J.S.M., Transmissibility of pandemic H1N1 and genetically related swine influenza viruses in ferrets, Options for the Control of Influenza VII, 2010, Hong Kong. 2010. |
| Researcher : Chu KW |
| List of Research Outputs |
| Chu K.W., Chin W.H., Smith G.J., Chan K.H., Guan Y., Peiris J.S.M. and Poon L.L.M., Detection of novel astroviruses in urban brown rats and previously known astroviruses in humans., J Gen Virol. . 2010, 91: 2457-2462. |
| Riley S., Kwok K.O., Wu K.M., Ning Y., Cowling B.J., Wu J.T.K., Ho L.M., Tsang T.H.F., Lo S.V., Chu K.W., Ma E.S.K. and Peiris J.S.M., Epidemiological characteristics of 2009 (H1N1) pandemic influenza based on paired sera from a longitudinal community cohort study, PLoS Medicine. 2011, 8(6): e1000442. |
| Wu J.T.K., Ma S.K., Lee C.K., Chu K.W., Ho P.L., Shen L., Ho W.K., Hung I.F.N., Riley S., Ho L.M., Lin C.K., Tsang T.H.F., Lo S.V., Lau Y.L., Leung G.M., Cowling B.J. and Peiris J.S.M., A serial cross-sectional serologic survey of 2009 Pandemic (H1N1) in Hong Kong: implications for future pandemic influenza surveillance (Options for the Control of Influenza VII, 3-7 September 2010, Hong Kong), Influenza and Other Respiratory Viruses. 2011, 5(Suppl 1): 190-194. |
| Wu J.T.K., Ma S.K., Lee C.K., Chu K.W., Ho P.L., Shen L., Ho W.K., Hung I.F.N., Riley S., Ho L.M., Lin C.K., Tsang T.H.F., Lo S.V., Lau Y.L., Leung G.M., Cowling B.J. and Peiris J.S.M., The infection attack rate and severity of 2009 pandemic H1N1 influenza in Hong Kong, Clinical Infectious Diseases. 2010, 51(10): 1184-1191. |
| Researcher : Chu KW |
| List of Research Outputs |
| Chu K.W., Chin W.H., Smith G.J., Chan K.H., Guan Y., Peiris J.S.M. and Poon L.L.M., Detection of novel astroviruses in urban brown rats and previously known astroviruses in humans., J Gen Virol. . 2010, 91: 2457-2462. |
| Riley S., Kwok K.O., Wu K.M., Ning Y., Cowling B.J., Wu J.T.K., Ho L.M., Tsang T.H.F., Lo S.V., Chu K.W., Ma E.S.K. and Peiris J.S.M., Epidemiological characteristics of 2009 (H1N1) pandemic influenza based on paired sera from a longitudinal community cohort study, PLoS Medicine. 2011, 8(6): e1000442. |
| Wu J.T.K., Ma S.K., Lee C.K., Chu K.W., Ho P.L., Shen L., Ho W.K., Hung I.F.N., Riley S., Ho L.M., Lin C.K., Tsang T.H.F., Lo S.V., Lau Y.L., Leung G.M., Cowling B.J. and Peiris J.S.M., A serial cross-sectional serologic survey of 2009 Pandemic (H1N1) in Hong Kong: implications for future pandemic influenza surveillance (Options for the Control of Influenza VII, 3-7 September 2010, Hong Kong), Influenza and Other Respiratory Viruses. 2011, 5(Suppl 1): 190-194. |
| Wu J.T.K., Ma S.K., Lee C.K., Chu K.W., Ho P.L., Shen L., Ho W.K., Hung I.F.N., Riley S., Ho L.M., Lin C.K., Tsang T.H.F., Lo S.V., Lau Y.L., Leung G.M., Cowling B.J. and Peiris J.S.M., The infection attack rate and severity of 2009 pandemic H1N1 influenza in Hong Kong, Clinical Infectious Diseases. 2010, 51(10): 1184-1191. |
| Researcher : Chu YC |
| List of Research Outputs |
| Chu Y.C., Cheung C.L., Leung C.Y.H., Poon L.L.M., Chen H., Peiris J.S.M. and Guan Y., Continuing Evolution Of H9n2 Influenza Viruses Endemic In Poultry In Southern China, In: JSM Peiris & Y Guan, Options For The Control of Influenza VII. Oxford, UK, Wiley-Blackwell, 2011, 5 Suppl 1: 68-71. |
| Chu Y.C., Cheung C.L., Leung C.Y.H., Poon L.L.M., Chen H., Peiris J.S.M. and Guan Y., Continuing evolution of H9N2 influenza viruses endemic in poultry in southern China, Influenza Other Respi Viruses. 2011, 5: 68-71. |
| Researcher : Chu YC |
| List of Research Outputs |
| Chu Y.C., Cheung C.L., Leung C.Y.H., Poon L.L.M., Chen H., Peiris J.S.M. and Guan Y., Continuing Evolution Of H9n2 Influenza Viruses Endemic In Poultry In Southern China, In: JSM Peiris & Y Guan, Options For The Control of Influenza VII. Oxford, UK, Wiley-Blackwell, 2011, 5 Suppl 1: 68-71. |
| Chu Y.C., Cheung C.L., Leung C.Y.H., Poon L.L.M., Chen H., Peiris J.S.M. and Guan Y., Continuing evolution of H9N2 influenza viruses endemic in poultry in southern China, Influenza Other Respi Viruses. 2011, 5: 68-71. |
| Researcher : Chui HK |
| List of Research Outputs |
| Woo P.C.Y., Ngan H.Y., Chui H.K., Lau S.K.P. and Yuen K.Y., Agar block smear preparation: a novel method of slide preparation for preservation of native fungal structures for microscopic examination and long-term storage, Journal of Clinical Microbiology. 2010, 48: 3053-3061. |
| Researcher : Curreem SOT |
| List of Research Outputs |
| Curreem S.O.T., Teng L.L., Tse H., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., General metabolism of Laribacter hongkongensis: a genome-wide analysis, Cell & Bioscience. 2011, 1: 16. |
| Lau S.K.P., Fan Y.Y., Ho C.C., Wong G.K.M., Tsang K.L., Teng L.L., Chen W., Watt R.M., Curreem S.O.T., Tse H., Yuen K.Y. and Woo P.C.Y., Environmental adaptability and stress tolerance of Laribacter hongkongensis: a genome wide analysis, Cell & Bioscience. 2011, 1: 22. |
| To K.K.W., Cheng V.C.C., Chan J.F.W., Wong A.C., Chau S., Tsang F.H.F., Curreem S.O.T., Lau S.K.P., Yuen K.Y. and Woo P.C.Y., Molecular characterization of a catalase-negative Staphylococcus aureus subsp. aureus from a patient with mitral valve endocarditis and pericarditis revealed novel nonsense mutation in katA gene., Journal of Clinical Microbiology. 2011. |
| Researcher : Dhanasekaran V |
| List of Research Outputs |
| Dhanasekaran V., Smith G.J., Pybus O.G., Zhu H., Bahl J., Poon L.L.M., Riley S., Bahl J., Ma S.K., Cheung C.L., Perera R.A.P.M., Chen H., Shortridge K.F., Webby R., Guan Y. and Peiris J.S.M., Long-term evolution and transmission dynamics of swine influenza A virus., Nature. 2011, 473: 519-22. |
| Huang K., Bahl J., Fan X... .H..., Dhanasekaran V., Cheung C.L., Webby R... .J..., Webster R... .G..., Chen H., Smith G.J., Peiris J.S.M. and Guan Y., Establishment of an H6N2 Influenza Virus Lineage in Domestic Ducks in Southern China., J Virol. 2010, 84: 6978-86. |
| Leung C.Y.H., Cheung P.H.P., Zhang L., Wu Y.O., Chow K.C., Ho C.K., Chow C.K., Ng C.F., Tsang C.L., Dhanasekaran V., Smith G.J., Guan Y. and Peiris J.S.M., Influenza Viruses In Wild Birds In Hong Kong, 2003-2010, In: JSM Peiris & Y Guan, Options For The Control Of Influenza VII. Oxford, UK, Wiley-Blackwell, 2011, 5: 77-78. |
| Leung C.Y.H., Cheung P.P.H., Zhang L., Wu Y.O., Chow K.C., Ho C.K., Chow C.K., Ng C.F., Li C., Tsang C.L., Dhanasekaran V., Smith G.J., Guan Y. and Peiris J.S.M., Influenza viruses in wild birds in Hong Kong, 2003-2010 , Influenza Other Respi Viruses. 2011, 5: 77-78. |
| Ma S.K., Ho P.L., Cheung C.Y., Tse T.M., Dhanasekaran V., Poon L.L.M., Guan Y. and Peiris J.S.M., Surveillance of influenza viruses in swine in Hong Kong abattoir: methods and feasibility, INFLUENZA AND OTHER RESPIRATORY VIRUSES. 2011, 5: 74-76. |
| Researcher : Du L |
| List of Research Outputs |
| Du L., Leung H.C., Jiang S. and Zheng B., A Recombinant Vaccine of H5N1 HA1 Fused with Foldon and Human IgG Fc Induced Complete Cross-Clade Protection against Divergent H5N1 Viruses. , 1st European Conference of Microbiology and Immunology.. Budapest, Hungary, 2011. |
| Du L., Leung H.C., Zhang X., Zhou J., Chen M., He W., Zhang H., Chan C.S., Poon K.M., Zhao G., Sun S., Cai L., Zhou Y., Zheng B. and Jiang S., A recombinant vaccine of H5N1 HA1 fused with foldon and human IgG Fc induced complete cross-clade protection against divergent H5N1 viruses., PloS One. 2011, 6(1):: e16555. |
| Du L., Zhao G., Zhang X., Liu Z., Yu H., Zheng B., Zhou Y. and Jiang S., Development of a safe and convenient neutralization assay for rapid screening of influenza HA-specific neutralizing monoclonal antibodies., Biochem Biophys Res Commun . 2010, 397(3):: 580-585. |
| Liu S., Li R., Zhang R., Chan C.S., Xi B., Zhu Z., Yang J., Poon K.M., Zhou J., Chen M., Munch J., Kirchhoff F., Pleschka S., Haarmann T., Dietrich U., Pan C., Du L., Jiang S. and Zheng B., CL-385319 inhibits H5N1 avian influenza A virus infection by blocking viral entry. , Eur J Pharmacol . 2011, 660:: 460-467. |
| Zhao G., Sun S., Du L., Xiao W., Ru Z., Guo Y., Yu H., Jiang S., Long Y., Zheng B. and Zhou Y., An H5N1 M2e-based multiple antigenic peptide vaccine confers heterosubtypic protection from lethal infection with pandemic 2009 H1N1 virus., Virol J. 2010, 7(1):: 151. |
| Zhao G., Lin Y., Guan J., Du L., Sui H., Chan C.S., Kou Z., Guo Y., Jiang S., Zhou Y. and Zheng B., An M2e-based polypeptide vaccine protects mice from lethal challenge with divergent H5N1 influenza viruses., 4TH Congress of European Microbiologists . Geneva, Switzerland., 2011. |
| Zhao G., Lin Y., Du L., Guan J., He Y., Sun S., Xiao W., Chen M., Chan C.S., Kou Z., Lustigman S., Jiang S., Zheng B. and Zhou Y., Induction of protection against divergent H5N1 influenza viruses using a recombinant fusion protein linking influenza M2e to Onchocerca volvulus activation associated protein-1 (ASP-1) adjuvant., Vaccine. 2010, 28(44):: 7233-40. |
| Zheng B., Du L., Zhao G., Lin Y., Sui H., Chan C.S., He Y., Jiang S., Zhou Y. and Yuen K.Y., SARS-CoV S Protein Induces Strong Mucosal Immune Responses and Provides Long-term Protection Against SARS-CoV Infection., In: Eighth International Symposium on Frontiers in Life Sciences New Advances and Challenges in Multidisciplinary Research., Yinchuan, China., 2010. |
| Researcher : Duan L |
| List of Research Outputs |
| Duan L., Zhu H., Wang J., Huang K., Cheung C.L., Peiris J.S.M., Chen H. and Guan Y., Influenza virus surveillance in migratory ducks and sentinel ducks at Poyang Lake, China., Influenza Other Respi Viruses. . 2011, Suppl 1: 65-68. |
| Duan L., Zhu H., Huang K., Wang J., Cheung C.L., Peiris J.S.M., Chen H. and Guan Y., Influenza virus surveillance in migratory ducks and sentinel ducks at Poyang Lake, China., Options for the Control of Influenza VII. 2010. |
| Huang K., Cheung C.L., Fan X., Zhu H., Wang J., Duan L., Webby R., Webster R., Chen H., Peiris J.S.M. and Guan Y., Interspecies transmission and lineage replacement of H6 subtype influenza viruses in Southern China. , Options for the Control of Influenza VII. 2010. |
| Zhu H., Duan L., Li L., Lam T.Y., Wang J., Smith D.K., Peiris J.S.M. and Guan Y., Detection of a novel swine influenza reassortant virus with human infectious potential and inter-species transmissibility from pigs to ferrets. , 40th Keystone Symposia on Molecular and Cellular Biology: Pathogenesis of Influenza: Virus-host Interactions. 2011. |
| Zhu H., Wang J., Zheng Z., Li L., Duan L., Yip C.H., Peiris J.S.M., Chen H. and Guan Y., Pathogenicity and transmissibility of the pandemic (H1N1) 2009-related influenza viruses in pigs and mice., Options for the Control of Influenza VII. 2010. |
| Zhu H., Wang J., Zheng Z., Chen R., Zheng R., Li L., Duan L., Zhang T., Yip C.H., Yan Z., Chen H., Peiris J.S.M. and Guan Y., Pathogenicity and transmissibility of the pandemic H1N1 2009-related influenza viruses in mice, ferrets, and pigs., Influenza Other Respi Viruses.. 2011, Suppl 1: 82-84. |
| Zhu H., Wang J., Wang P., Song W., Zheng Z., Chen R., Guo K., Zhang T., Duan L., Li L., Yip C.H., Peiris J.S.M., Chen H. and Guan Y., Substitution of E627K in PB2 protein does not change virulence of the 2009 pandemic H1N1 virus in mice., Options for the Control of Influenza VII. 2010. |
| Researcher : Fan YY |
| List of Research Outputs |
| Lau S.K.P., Fan Y.Y., Ho C.C., Wong G.K.M., Tsang K.L., Teng L.L., Chen W., Watt R.M., Curreem S.O.T., Tse H., Yuen K.Y. and Woo P.C.Y., Environmental adaptability and stress tolerance of Laribacter hongkongensis: a genome wide analysis, Cell & Bioscience. 2011, 1: 22. |
| Lau S.K.P., Wong G.K.M., Tsang K.L., Teng L.L., Fan Y.Y., Tse H., Yuen K.Y. and Woo P.C.Y., Virulence determinants, drug resistance and mobile genetic elements of Laribacter hongkongensis: a genome-wide analysis, Cell & Bioscience. 2011, 1: 17. |
| Researcher : Fu CT |
| List of Research Outputs |
| Lau S.K.P., Woo P.C.Y., Yip C.Y., Li K.S.M., Fu C.T., Huang Y., Chan K.H. and Yuen K.Y., Co-existence of multiple strains of two novel porcine bocaviruses in the same pig, a previously undescribed phenomenon in members of the family Parvoviridae and evidence for inter- and intra-host genetic diversity and recombination, Journal of General Virology. 2011, 92: 2047-2059. |
| Researcher : Gai W |
| List of Research Outputs |
| Lee M.Y., Gai W., Cheung K.W. and Peiris J.S.M., Antiviral activity of a selective COX-2 inhibitor NS-398 on avian influenza H5N1 infection, Influenza and other respiratory viruses. Wiley-Blackwell, 2011, 5(Suppl.1): 230-251. |
| Lee M.Y., Gai W., Cheung K.W. and Peiris J.S.M., Antiviral activity of a selective COX-2 inhibitor, NS-398 on avain influenza H5N1 infection., Options for the Control of Influenza VII, 2010. |
| Researcher : Guan Y |
| Project Title: | Vaccines for the control of H5N1 and other avian influenza viruses |
| Investigator(s): | Guan Y |
| Department: | Microbiology |
| Source(s) of Funding: | The University of Hong Kong Foundation Seed Grant |
| Start Date: | 04/2002 |
| Project Title: | Searching for the precursor of SARS-Cov in Southern China |
| Investigator(s): | Guan Y |
| Department: | Microbiology |
| Source(s) of Funding: | VCO SARS Research Fund |
| Start Date: | 07/2003 |
| Project Title: | State Key Laboratory of Emerging Infectious Diseases |
| Investigator(s): | Guan Y |
| Department: | Microbiology |
| Source(s) of Funding: | Matching Fund for State Key Laboratory (SKL) |
| Start Date: | 02/2009 |
| Project Title: | Long-term surveillance for bat-borne viruses: An insight into viral ecology, evolutionary dynamics, and the source of zoonoses |
| Investigator(s): | Guan Y, Dhanasekaran V, Lai ACK, Zhu H |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2010 |
| List of Research Outputs |
| Barber M.R.W., Guan Y., Magor K.E., Peiris J.S.M. and Webster R.G., The role of animal surveillance in influenza preparedness: the consequence of inapparent infection in ducks and pigs, Influenza Other Respi Viruses. 2011, 5: 8-11. |
| Chan M.C.W., Chan W.Y., Yen H., Yu C.L., Yuen K.M., Tang L.L.S., Li C.L., Kang S.R., Hui F.F., Lai W.W.K., Sihoe A.D.L., Guan Y., Nicholls J.M. and Peiris J.S.M., ) Tropism and innate host response of the 2009 pandemic H1N1 influenza virus compared with related swine influenza viruses and reassortants in ex vivo and in vitro cultures of the human respiratory tract and conjunctiva, Options for the Control of Influenza VII, 2010. |
| Chan M.C.W., Chan W.Y., Yen H., Lee M.Y., Guan Y., Nicholls J.M. and Peiris J.S.M., Comparing the tropism of the pandemic H1N1/2009 influenza virus with seasonal influenza virus, related swine influenza viruses and reassortants in ex vivo and in vitro cultures of human conjunctiva and respiratory tract., 4th Annual Center of Excellence for Influenza Research and Surveillance Network Meeting, Woodcliff Hotel and Conference Center 199 Woodcliff Drive, Fairport, NY 14450 . 2010. |
| Chan M.C.W., Chan W.Y., Yen H., Yu C.L., Yuen K.M., Tang L.L.S., Li C.L., Kang S.R., Hui F.F., Lai W.W.K., Sihoe A.D.L., Guan Y., Nicholls J.M. and Peiris J.S.M., Tropism and innate host response of the 2009 pandemic H2N2 influenza virus compared with related swine influenza viruses and reassortants in ex vivo and in vitro cultures of the human respiratory tract and conjunctiva, Influenza and other respiratory viruses. 2011, 5 (S1): 54-55. |
| Chu K.W., Chin W.H., Smith G.J., Chan K.H., Guan Y., Peiris J.S.M. and Poon L.L.M., Detection of novel astroviruses in urban brown rats and previously known astroviruses in humans., J Gen Virol. . 2010, 91: 2457-2462. |
| Chu Y.C., Cheung C.L., Leung C.Y.H., Poon L.L.M., Chen H., Peiris J.S.M. and Guan Y., Continuing Evolution Of H9n2 Influenza Viruses Endemic In Poultry In Southern China, In: JSM Peiris & Y Guan, Options For The Control of Influenza VII. Oxford, UK, Wiley-Blackwell, 2011, 5 Suppl 1: 68-71. |
| Chu Y.C., Cheung C.L., Leung C.Y.H., Poon L.L.M., Chen H., Peiris J.S.M. and Guan Y., Continuing evolution of H9N2 influenza viruses endemic in poultry in southern China, Influenza Other Respi Viruses. 2011, 5: 68-71. |
| Danesh A., Cameron C.M., Leon A.J., Ran L., Xu L., Fang Y., Kelvin A.A., Rowe T., Chen H., Guan Y., Jonsson C.B., Cameron M.J. and Kelvin D.J., Early gene expression events in ferrets in response to SARS coronavirus infection versus direct interferon-alpha2b stimulation, Virology. 2011, 409(1): 102-12. |
| Dhanasekaran V., Smith G.J., Pybus O.G., Zhu H., Bahl J., Poon L.L.M., Riley S., Bahl J., Ma S.K., Cheung C.L., Perera R.A.P.M., Chen H., Shortridge K.F., Webby R., Guan Y. and Peiris J.S.M., Long-term evolution and transmission dynamics of swine influenza A virus., Nature. 2011, 473: 519-22. |
| Duan L., Zhu H., Wang J., Huang K., Cheung C.L., Peiris J.S.M., Chen H. and Guan Y., Influenza virus surveillance in migratory ducks and sentinel ducks at Poyang Lake, China., Influenza Other Respi Viruses. . 2011, Suppl 1: 65-68. |
| Duan L., Zhu H., Huang K., Wang J., Cheung C.L., Peiris J.S.M., Chen H. and Guan Y., Influenza virus surveillance in migratory ducks and sentinel ducks at Poyang Lake, China., Options for the Control of Influenza VII. 2010. |
| Ducatez M.F., Bahl J., Griffin Y., Stigger-Rosser E., Franks J., Barman S., Vijaykrishna D., Webb A., Guan Y., Webster R.G., Smith G.J. and Webby R.J., Feasibility of reconstructed ancestral H5N1 influenza viruses for cross-clade protective vaccine development, Proc Natl Acad Sci USA. 2011, 108(1): 349-54. |
| Guan Y., Establishment and lineage replacement of H6N2 influenza viruses in domestic ducks in Southern China (2000-2007), 4th Annual CEIRS Network Meeting. 2010. |
| Guan Y., Excellent Research Award (Basic and Laboratory Science), The Food and Health Bureau, the Government of the Hong Kong Special Administration Region. 2010. |
| Guan Y., Genetic characterisation of H5N1 viruses isolated from different regions of southern China, Hong Kong Med J. 2010, 16: 27-8. |
| Huang K., Bahl J., Fan X... .H..., Dhanasekaran V., Cheung C.L., Webby R... .J..., Webster R... .G..., Chen H., Smith G.J., Peiris J.S.M. and Guan Y., Establishment of an H6N2 Influenza Virus Lineage in Domestic Ducks in Southern China., J Virol. 2010, 84: 6978-86. |
| Huang K., Cheung C.L., Fan X., Zhu H., Wang J., Duan L., Webby R., Webster R., Chen H., Peiris J.S.M. and Guan Y., Interspecies transmission and lineage replacement of H6 subtype influenza viruses in Southern China. , Options for the Control of Influenza VII. 2010. |
| Lam T.Y., Zhu H., Wang J., Smith D.K., Holmes E.C., Webster R.G., Webby R., Peiris J.S.M. and Guan Y., Reassortment Events between European Avian-like and American Triple-Reassortant Swine Influenza Viruses in southern China., National Institute of Allergy and Infectious Diseases 5th Annual CEIRS Network Meeting. 2011. |
| Lee M.Y., Chan W.Y., Gardy D.L., Lo C.K., Sihoe A.D.L., Kang S.R., Cheung K.W., Guan Y., Chan M.C.W., Hancock R.E. and Peiris J.S.M., Systems-level comparison of host responses induced by pandemic and seasonal influenza A H1N1 viruses in primary human type I-like alveolar epithelial cells in vitro, Respiratory Research. 2010, 11: 147. |
| Leung C.Y.H., Cheung P.H.P., Zhang L., Wu Y.O., Chow K.C., Ho C.K., Chow C.K., Ng C.F., Tsang C.L., Dhanasekaran V., Smith G.J., Guan Y. and Peiris J.S.M., Influenza Viruses In Wild Birds In Hong Kong, 2003-2010, In: JSM Peiris & Y Guan, Options For The Control Of Influenza VII. Oxford, UK, Wiley-Blackwell, 2011, 5: 77-78. |
| Leung C.Y.H., Cheung P.P.H., Zhang L., Wu Y.O., Chow K.C., Ho C.K., Chow C.K., Ng C.F., Li C., Tsang C.L., Dhanasekaran V., Smith G.J., Guan Y. and Peiris J.S.M., Influenza viruses in wild birds in Hong Kong, 2003-2010 , Influenza Other Respi Viruses. 2011, 5: 77-78. |
| Ma S.K., Ho P.L., Cheung C.Y., Tse T.M., Dhanasekaran V., Poon L.L.M., Guan Y. and Peiris J.S.M., Surveillance of influenza viruses in swine in Hong Kong abattoir: methods and feasibility, INFLUENZA AND OTHER RESPIRATORY VIRUSES. 2011, 5: 74-76. |
| Mak W.Y., Wong K.S.C., Li O.T.W., Chan K.H., Cheung C.L., Ma S.K., Webby R.I.C.H.A.R.D., Guan Y., Peiris J.S.M. and Poon L.L.M., Rapid genotyping of swine influenza viruses., Emerg Infect Dis.. 2011, 17: 691-694. |
| Smith G.J.D. and Guan Y., Ecology and evolution of H5N1 in birds, Influenza and Other Respi Viruses. 2010, 4: 35. |
| Tu W., Mao H., Zheng J., Liu Y., Chiu S.S.S., Qin G., Chan P.L., Lam K.T., Guan J., Zhang L., Guan Y., Yuen K.Y., Peiris J.S.M. and Lau Y.L., Cytotoxic T Lymphocytes Established by Seasonal Human Influenza Cross-react against 2009 Pandemic H1N1 Influenza Virus., Journal of Virology. 2010, 84: 6527-35. |
| Tu W., Mao H., Zheng J., Liu Y., Chiu S.S.S., Qin G., Chan P.L., Lam K.T., Guan J., Zhang L., Guan Y., Yuen K.Y., Peiris J.S.M. and Lau Y.L., Cytotoxic T lymphocytes established by seasonal human influenza cross-react against 2009 pandemic H1N1 influenza virus, J Virol. 2010, 84(13): 6527-35. |
| Yen H., Liang C., Wu C., Forrest H., Ferguson A., Choy K.T., Jones J., Wong D.D.Y., Cheung P.H.P., Hsu C., Li O.T.W., Yuen K.M., Chan W.Y., Poon L.L.M., Chan M.C.W., Nicholls J.M., Krauss S., Wong C.H., Guan Y., Webster R.G., Webby R. and Peiris J.S.M., Hemagglutinin-neuraminidase balance confers respiratory droplet transmissibility of the pandemic H1N1 influenza virus in ferrets, Keystone Symposia (Pathogenesis of Influenza: Virus-Host Interactions), May 23-28, 2011, Hong Kong SAR. 2011. |
| Yen H., Forrest H., Cheung P.P.H., Wong D.D.Y., Li O.T.W., Krauss S., Ferguson A., Crumpton J.C., Jones J., Choy K.T., Ma S.K., Poon L.L.M., Smith G.J., Nicholls J.M., Guan Y., Webster R.G., Webby R. and Peiris J.S.M., Transmissibility of pandemic H1N1 and genetically related swine influenza viruses in ferrets, Influenza Other Respi Viruses. 2011, 5: 85-87. |
| Yen H., Forrest H., Cheung P.P.H., Wong D.D.Y., Li O.T.W., Krauss S., Ferguson A., Crumpton J.C., Jones J., Choy K.T., Ma S.K., Poon L.L.M., Smith G.J., Nicholls J.M., Guan Y., Webster R., Webby R. and Peiris J.S.M., Transmissibility of pandemic H1N1 and genetically related swine influenza viruses in ferrets, Options for the Control of Influenza VII, 2010, Hong Kong. 2010. |
| Zhu H., Duan L., Li L., Lam T.Y., Wang J., Smith D.K., Peiris J.S.M. and Guan Y., Detection of a novel swine influenza reassortant virus with human infectious potential and inter-species transmissibility from pigs to ferrets. , 40th Keystone Symposia on Molecular and Cellular Biology: Pathogenesis of Influenza: Virus-host Interactions. 2011. |
| Zhu H., Wang J., Chen H., Webster R., Webby R., Peiris J.S.M. and Guan Y., Influenza surveillance program in swine in Southern China (Dec 2009-Jun 2010), National Institute of Allergy and Infectious Diseases 4th Annual CEIRS Network Meeting. 2010. |
| Zhu H., Wang J., Zheng Z., Li L., Duan L., Yip C.H., Peiris J.S.M., Chen H. and Guan Y., Pathogenicity and transmissibility of the pandemic (H1N1) 2009-related influenza viruses in pigs and mice., Options for the Control of Influenza VII. 2010. |
| Zhu H., Wang J., Zheng Z., Chen R., Zheng R., Li L., Duan L., Zhang T., Yip C.H., Yan Z., Chen H., Peiris J.S.M. and Guan Y., Pathogenicity and transmissibility of the pandemic H1N1 2009-related influenza viruses in mice, ferrets, and pigs., Influenza Other Respi Viruses.. 2011, Suppl 1: 82-84. |
| Zhu H., Smith D.K., Lam T.Y., Li L., Zheng Z., Chen R., Zheng R., Zeng Y., Zhou J., Wang J., Chen H., Webster R.G., Webby R., Peiris J.S.M. and Guan Y., Reassortants of the pandemic H1N1/2009 virus in swine and their potential to infect human., National Institute of Allergy and Infectious Diseases 5th Annual CEIRS Network Meeting. 2011. |
| Zhu H., Wang J., Wang P., Song W., Zheng Z., Chen R., Guo K., Zhang T., Duan L., Li L., Yip C.H., Peiris J.S.M., Chen H. and Guan Y., Substitution of E627K in PB2 protein does not change virulence of the 2009 pandemic H1N1 virus in mice., Options for the Control of Influenza VII. 2010. |
| Researcher : Guo K |
| List of Research Outputs |
| Chan K.H., Zhang J., To K.K.W., Chan C.S., Poon K.M., Guo K., Ng F., Zhang Q., Leung H.C., Cheung A.N.Y., Lau C.Y., Woo P.C.Y., Tse H., Wu W.L., Chen H., Zheng B. and Yuen K.Y., Wild type and mutant 2009 pandemic influenza A (H1N1) viruses cause more severe disease and higher mortality in pregnant BALB/c mice, PLoS One. 2010, 5: e13757. |
| Lau S.K.P., Poon R.W.S., Wong B.H.L., Wang M., Huang Y., Xu H., Guo R., Li K.S.M., Guo K., Chan K.H., Zheng B., Woo P.C.Y. and Yuen K.Y., Coexistence of different genotypes in the same bat and serological characterization of Rousettus bat coronavirus HKU9 belonging to a novel Betacoronavirus subgroup. , J Virol. 2010, 84(21):: 11358-94. |
| Researcher : Ho CC |
| List of Research Outputs |
| Ho C.C., Lau C.Y., Mertelli P., Chan S.Y., Tse C.W.S., Wu A.K.L., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Novel pan-genomic analysis approach in target selection for multiplex PCR identification and detection of Burkholderia pseudomallei, Burkholderia thailandensis and Burkholderia cepacia complex species: a proof-of-concept study, Journal of Clinical Microbiology. 2011, 49: 814-821. |
| Lau S.K.P., Fan Y.Y., Ho C.C., Wong G.K.M., Tsang K.L., Teng L.L., Chen W., Watt R.M., Curreem S.O.T., Tse H., Yuen K.Y. and Woo P.C.Y., Environmental adaptability and stress tolerance of Laribacter hongkongensis: a genome wide analysis, Cell & Bioscience. 2011, 1: 22. |
| Researcher : Ho CK |
| List of Research Outputs |
| Leung C.Y.H., Cheung P.H.P., Zhang L., Wu Y.O., Chow K.C., Ho C.K., Chow C.K., Ng C.F., Tsang C.L., Dhanasekaran V., Smith G.J., Guan Y. and Peiris J.S.M., Influenza Viruses In Wild Birds In Hong Kong, 2003-2010, In: JSM Peiris & Y Guan, Options For The Control Of Influenza VII. Oxford, UK, Wiley-Blackwell, 2011, 5: 77-78. |
| Leung C.Y.H., Cheung P.P.H., Zhang L., Wu Y.O., Chow K.C., Ho C.K., Chow C.K., Ng C.F., Li C., Tsang C.L., Dhanasekaran V., Smith G.J., Guan Y. and Peiris J.S.M., Influenza viruses in wild birds in Hong Kong, 2003-2010 , Influenza Other Respi Viruses. 2011, 5: 77-78. |
| Researcher : Ho PL |
| Project Title: | A phenotypic and genotypic analysis of vancomycin tolerance in Streptococcus pnemoniae |
| Investigator(s): | Ho PL, Yuen KY, Que TL |
| Department: | Microbiology |
| Source(s) of Funding: | Low Budget High Impact Programme |
| Start Date: | 11/2000 |
| Project Title: | Molecular epidemiology of fluoroquinolone-resistant streptococcus pneumoniae in Hong kong and Canada |
| Investigator(s): | Ho PL |
| Department: | Microbiology |
| Source(s) of Funding: | Low Budget High Impact Programme |
| Start Date: | 11/2001 |
| Project Title: | Risk factors for SARS in health care workers following incubation of SARS patients |
| Investigator(s): | Ho PL, Hung CT |
| Department: | Microbiology |
| Source(s) of Funding: | VCO SARS Research Fund |
| Start Date: | 07/2003 |
| Project Title: | Fluoroquinolone susceptibility clinical breakpoints and fluoroquinolone-resistant determining mutations among clinical strains of streptococcus pneumoniae |
| Investigator(s): | Ho PL, Wong SSY |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2003 |
| Project Title: | Evaluation of molecular tests for the rapid detection of rifampicin and isoniazid resistance in Mycobacterium tuberculosis and their impact on patient management |
| Investigator(s): | Ho PL, Yam WC, Leung CC, Yew WW, Mok YW, Chan KS, Tam CM |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 04/2006 |
| List of Research Outputs |
| Cheng V.C.C., Wong L.M., Tai J.W., Chan J.F.W., To K.K.W., Li W.S., Hung I.F.N., Chan K.H., Ho P.L. and Yuen K.Y., Prevention of nosocomial transmission of norovirus by strategic infection control measures, Infection control and hospital epidemiology. 2011, 32(3): 229-37. |
| Cheng V.C.C., Tai J.W.M., Chan W.M., Lau E.H.Y., Chan J.F.W., To K.K.W., Li W.S., Ho P.L. and Yuen K.Y., Sequential introduction of single room isolation and hand hygiene campaign in the control of methicillin-resistant Staphylococcus aureus in intensive care unit., BMC infectious diseases. 2010, 10: 263. |
| Cheng V.C.C., Chan J.F.W., Lau E.H.Y., Yam W.C., Ho S.K.Y., Yau M.C.Y., Tse E.Y.F., Wong A.C.Y., Tai J.W.M., Fan S.T., Ho P.L. and Yuen K.Y., Studying the transmission dynamics of meticillin-resistant Staphylococcus aureus in Hong Kong using spa typing, Journal of Hospital Infection. 2011, 79(3): 206-210. |
| Ho P.L., Lo W.U., Yeung M.K., Lin C., Chow K.H., Ang L., Tong A.H.Y., Bao Y., Lok S. and Lo J.Y., Complete sequencing of pNDM-HK encoding NDM-1 carbapenemase from a multidrug-resistant Escherichia coli strain isolated in Hong Kong. , PLoS One. 2011, 6: e17989. |
| Ho P.L., Chiu S.S.S., Ang L. and Lau Y.L., Serotypes and antimicrobial susceptibilities of invasive Streptococcus pneumoniae before and after introduction of 7-valent pneumococcal conjugate vaccine, Hong Kong, 1995-2009., Vaccine. 2011, 29(17): 3270-3275. |
| Ho P.L., Ang L., Chow K.H., Lai E.L.Y. and Chiu S.S.S., The prevalence and characteristics of Streptococcus pneumoniae isolates expressing serotypes 6C and 6D in Hong Kong prior to the introduction of the 7-valent pneumococcal conjugate vaccine , Diagnostic Microbiology and Infectious Disease. 2010. |
| Hung I.F.N., To K.K.W., Lee C.K., Lin C.K., Chan J.F.W., Tse H., Cheng V.C.C., Chen H., Ho P.L., Tse C.W., Ng T.K., Que T.L., Chan K.H. and Yuen K.Y., Effect of Clinical and Virological Parameters on the Level of Neutralizing Antibody against Pandemic Influenza A Virus H1N1 2009, Clin Infect Dis.. 2010, 51: 274-9. |
| Hung I.F.N., To K.K.W., Lee C.K., Lin C.K., Chan J.F.W., Tse H., Cheng V.C.C., Chen H., Ho P.L., Tse C.W.S., Ng T.K., Que T.L., Chan K.H. and Yuen K.Y., Effect of clinical and virological parameters on the level of neutralizing antibody against pandemic influenza A virus H1N1 2009., Clinical Infectious Disease. 2010, 51: 274-9. |
| Hung I.F.N., Leung A.Y.M., Chu D.W.S., Leung Y.P., Cheung T..., Chan C.K., Lam C.L.K., Liu S...H..., Chu C...M..., Ho P.L., Chan S.S.C., Lam T.H., Liang R.H.S. and Yuen K.Y., Prevention of acute myocardial infarction and stroke among elderly persons by dual pneumococcal and influenza vaccination: a prospective cohort study, Clinical Infectious Diseases. 2010, 51(9): 1007-1016. |
| Li C.B., Au K.Y., Fang J.W., Yim H.C.H., Chow K.H., Ho P.L. and Lau A.S.Y., HIV-1 trans-activator protein dysregulates IFN-γ signaling and contributes to the suppression of autophagy induction., AIDS. 2011, 25(1): 15-25. |
| Ma S.K., Ho P.L., Cheung C.Y., Tse T.M., Dhanasekaran V., Poon L.L.M., Guan Y. and Peiris J.S.M., Surveillance of influenza viruses in swine in Hong Kong abattoir: methods and feasibility, INFLUENZA AND OTHER RESPIRATORY VIRUSES. 2011, 5: 74-76. |
| Wu J.T.K., Ma S.K., Lee C.K., Chu K.W., Ho P.L., Shen L., Ho W.K., Hung I.F.N., Riley S., Ho L.M., Lin C.K., Tsang T.H.F., Lo S.V., Lau Y.L., Leung G.M., Cowling B.J. and Peiris J.S.M., A serial cross-sectional serologic survey of 2009 Pandemic (H1N1) in Hong Kong: implications for future pandemic influenza surveillance (Options for the Control of Influenza VII, 3-7 September 2010, Hong Kong), Influenza and Other Respiratory Viruses. 2011, 5(Suppl 1): 190-194. |
| Wu J.T.K., Ma S.K., Lee C.K., Chu K.W., Ho P.L., Shen L., Ho W.K., Hung I.F.N., Riley S., Ho L.M., Lin C.K., Tsang T.H.F., Lo S.V., Lau Y.L., Leung G.M., Cowling B.J. and Peiris J.S.M., The infection attack rate and severity of 2009 pandemic H1N1 influenza in Hong Kong, Clinical Infectious Diseases. 2010, 51(10): 1184-1191. |
| Researcher : Ho PL |
| List of Research Outputs |
| Cheng V.C.C., Wong L.M., Tai J.W., Chan J.F.W., To K.K.W., Li W.S., Hung I.F.N., Chan K.H., Ho P.L. and Yuen K.Y., Prevention of nosocomial transmission of norovirus by strategic infection control measures, Infection control and hospital epidemiology. 2011, 32(3): 229-37. |
| Cheng V.C.C., Tai J.W.M., Chan W.M., Lau E.H.Y., Chan J.F.W., To K.K.W., Li W.S., Ho P.L. and Yuen K.Y., Sequential introduction of single room isolation and hand hygiene campaign in the control of methicillin-resistant Staphylococcus aureus in intensive care unit., BMC infectious diseases. 2010, 10: 263. |
| Cheng V.C.C., Chan J.F.W., Lau E.H.Y., Yam W.C., Ho S.K.Y., Yau M.C.Y., Tse E.Y.F., Wong A.C.Y., Tai J.W.M., Fan S.T., Ho P.L. and Yuen K.Y., Studying the transmission dynamics of meticillin-resistant Staphylococcus aureus in Hong Kong using spa typing, Journal of Hospital Infection. 2011, 79(3): 206-210. |
| Ho P.L., Lo W.U., Yeung M.K., Lin C., Chow K.H., Ang L., Tong A.H.Y., Bao Y., Lok S. and Lo J.Y., Complete sequencing of pNDM-HK encoding NDM-1 carbapenemase from a multidrug-resistant Escherichia coli strain isolated in Hong Kong. , PLoS One. 2011, 6: e17989. |
| Ho P.L., Chiu S.S.S., Ang L. and Lau Y.L., Serotypes and antimicrobial susceptibilities of invasive Streptococcus pneumoniae before and after introduction of 7-valent pneumococcal conjugate vaccine, Hong Kong, 1995-2009., Vaccine. 2011, 29(17): 3270-3275. |
| Ho P.L., Ang L., Chow K.H., Lai E.L.Y. and Chiu S.S.S., The prevalence and characteristics of Streptococcus pneumoniae isolates expressing serotypes 6C and 6D in Hong Kong prior to the introduction of the 7-valent pneumococcal conjugate vaccine , Diagnostic Microbiology and Infectious Disease. 2010. |
| Hung I.F.N., To K.K.W., Lee C.K., Lin C.K., Chan J.F.W., Tse H., Cheng V.C.C., Chen H., Ho P.L., Tse C.W., Ng T.K., Que T.L., Chan K.H. and Yuen K.Y., Effect of Clinical and Virological Parameters on the Level of Neutralizing Antibody against Pandemic Influenza A Virus H1N1 2009, Clin Infect Dis.. 2010, 51: 274-9. |
| Hung I.F.N., To K.K.W., Lee C.K., Lin C.K., Chan J.F.W., Tse H., Cheng V.C.C., Chen H., Ho P.L., Tse C.W.S., Ng T.K., Que T.L., Chan K.H. and Yuen K.Y., Effect of clinical and virological parameters on the level of neutralizing antibody against pandemic influenza A virus H1N1 2009., Clinical Infectious Disease. 2010, 51: 274-9. |
| Hung I.F.N., Leung A.Y.M., Chu D.W.S., Leung Y.P., Cheung T..., Chan C.K., Lam C.L.K., Liu S...H..., Chu C...M..., Ho P.L., Chan S.S.C., Lam T.H., Liang R.H.S. and Yuen K.Y., Prevention of acute myocardial infarction and stroke among elderly persons by dual pneumococcal and influenza vaccination: a prospective cohort study, Clinical Infectious Diseases. 2010, 51(9): 1007-1016. |
| Li C.B., Au K.Y., Fang J.W., Yim H.C.H., Chow K.H., Ho P.L. and Lau A.S.Y., HIV-1 trans-activator protein dysregulates IFN-γ signaling and contributes to the suppression of autophagy induction., AIDS. 2011, 25(1): 15-25. |
| Ma S.K., Ho P.L., Cheung C.Y., Tse T.M., Dhanasekaran V., Poon L.L.M., Guan Y. and Peiris J.S.M., Surveillance of influenza viruses in swine in Hong Kong abattoir: methods and feasibility, INFLUENZA AND OTHER RESPIRATORY VIRUSES. 2011, 5: 74-76. |
| Wu J.T.K., Ma S.K., Lee C.K., Chu K.W., Ho P.L., Shen L., Ho W.K., Hung I.F.N., Riley S., Ho L.M., Lin C.K., Tsang T.H.F., Lo S.V., Lau Y.L., Leung G.M., Cowling B.J. and Peiris J.S.M., A serial cross-sectional serologic survey of 2009 Pandemic (H1N1) in Hong Kong: implications for future pandemic influenza surveillance (Options for the Control of Influenza VII, 3-7 September 2010, Hong Kong), Influenza and Other Respiratory Viruses. 2011, 5(Suppl 1): 190-194. |
| Wu J.T.K., Ma S.K., Lee C.K., Chu K.W., Ho P.L., Shen L., Ho W.K., Hung I.F.N., Riley S., Ho L.M., Lin C.K., Tsang T.H.F., Lo S.V., Lau Y.L., Leung G.M., Cowling B.J. and Peiris J.S.M., The infection attack rate and severity of 2009 pandemic H1N1 influenza in Hong Kong, Clinical Infectious Diseases. 2010, 51(10): 1184-1191. |
| Researcher : Huang K |
| List of Research Outputs |
| Duan L., Zhu H., Wang J., Huang K., Cheung C.L., Peiris J.S.M., Chen H. and Guan Y., Influenza virus surveillance in migratory ducks and sentinel ducks at Poyang Lake, China., Influenza Other Respi Viruses. . 2011, Suppl 1: 65-68. |
| Duan L., Zhu H., Huang K., Wang J., Cheung C.L., Peiris J.S.M., Chen H. and Guan Y., Influenza virus surveillance in migratory ducks and sentinel ducks at Poyang Lake, China., Options for the Control of Influenza VII. 2010. |
| Huang K., Bahl J., Fan X... .H..., Dhanasekaran V., Cheung C.L., Webby R... .J..., Webster R... .G..., Chen H., Smith G.J., Peiris J.S.M. and Guan Y., Establishment of an H6N2 Influenza Virus Lineage in Domestic Ducks in Southern China., J Virol. 2010, 84: 6978-86. |
| Huang K., Cheung C.L., Fan X., Zhu H., Wang J., Duan L., Webby R., Webster R., Chen H., Peiris J.S.M. and Guan Y., Interspecies transmission and lineage replacement of H6 subtype influenza viruses in Southern China. , Options for the Control of Influenza VII. 2010. |
| Researcher : Huang Y |
| List of Research Outputs |
| Lau S.K.P., Poon R.W.S., Wong B.H.L., Wang M., Huang Y., Xu H., Guo R., Li K.S.M., Guo K., Chan K.H., Zheng B., Woo P.C.Y. and Yuen K.Y., Coexistence of different genotypes in the same bat and serological characterization of Rousettus bat coronavirus HKU9 belonging to a novel Betacoronavirus subgroup. , J Virol. 2010, 84(21):: 11358-94. |
| Woo P.C.Y., Huang Y., Lau S.K.P. and Yuen K.Y., Coronavirus genomics and bioinformatics analysis, Viruses. 2010, 2: 1804-1820. |
| Researcher : Hui FF |
| List of Research Outputs |
| Chan M.C.W., Chan W.Y., Yen H., Yu C.L., Yuen K.M., Tang L.L.S., Li C.L., Kang S.R., Hui F.F., Lai W.W.K., Sihoe A.D.L., Guan Y., Nicholls J.M. and Peiris J.S.M., ) Tropism and innate host response of the 2009 pandemic H1N1 influenza virus compared with related swine influenza viruses and reassortants in ex vivo and in vitro cultures of the human respiratory tract and conjunctiva, Options for the Control of Influenza VII, 2010. |
| Chan M.C.W., Chan W.Y., Yen H., Yu C.L., Yuen K.M., Tang L.L.S., Li C.L., Kang S.R., Hui F.F., Lai W.W.K., Sihoe A.D.L., Guan Y., Nicholls J.M. and Peiris J.S.M., Tropism and innate host response of the 2009 pandemic H2N2 influenza virus compared with related swine influenza viruses and reassortants in ex vivo and in vitro cultures of the human respiratory tract and conjunctiva, Influenza and other respiratory viruses. 2011, 5 (S1): 54-55. |
| Chan W.Y., Hui F.F., Kang S.R., Yu C.L., Nicholls J.M. and Chan M.C.W., Replication and innate host response of influenza A virus in human lung microvascular endothelial cells: insights into systemic dissemination and pathogenesis , Options for the Control of Influenza VII. 2010. |
| Hui F.F., Chan W.Y., Fung K.H.Y., Yu C.L., Tsao G.S.W., Chan M.C.W. and Nicholls J.M., The regional distribution of different types of influenza receptors in cultured human alveolar epithelial cells and correlation with in vitro infection, Influenza and other respiratory viruses. 2011, 5(S1): 436-437. |
| Hui F.F., Chan W.Y., Fung K.H.Y., Yu C.L., Tsao G.S.W., Chan M.C.W. and Nicholls J.M., The regional distribution of different types of influenza receptors in cultured human alveolar epithelial cells and correlation with in vitro infection, Influenza and other respiratory viruses. 2011, 5(S1): 436-437. |
| Hui F.F., Chan W.Y., Fung K.H.Y., Yu C.L., Tsao G.S.W., Chan M.C.W. and Nicholls J.M., The regional distribution of different types of influenza receptors in cultured human alveolar epithelial cells and correlation with in vitro infection, Options for the Control of Influenza VII. 2010. |
| Li C.L., Chan W.Y., Hui F.F., Kang S.R., Yu C.L., Nicholls J.M. and Chan M.C.W., Replication and innate host response of influenza A virus in lung microvascular endothelial cells: new insights into systemic infection and pathogenesis, Influenza and other respiratory viruses. 2011, 5 (S1): 287-288. |
| Researcher : Hui PY |
| Project Title: | Role of retinoic acid inducible gene-1, toll-like receptor-3 and -8 in cytokine induction by influenza A H5N1 and pandemic H1N1 viruses in primary human cells |
| Investigator(s): | Hui PY, Peiris JSM, Cheung CY, Chan MCW, Lee MY, Chan WY |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 11/2010 |
| Project Title: | Role of focal adhesion kinase in cytokine production by influenza A H5N1 infection |
| Investigator(s): | Hui PY, Peiris JSM |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2011 |
| List of Research Outputs |
| Hui P.Y., Boehringer Ingelheim Fonds Travel Grant, Boehringer Ingelheim Fonds. 2010. |
| Hui P.Y., Keystone Symposia Scholarship, Keystone Symposia. 2011. |
| Hui P.Y., Promising Investigator Scholarship, Options for the Control of Influenza VII. 2010. |
| Hui P.Y., Lee M.Y., Cheung C.Y., Peiris J.S.M. and Peiris J.S.M., The Role of Innate Sensing Receptors in H5N1 Associated Hyper-induction of Cytokines , Influenza and other respiratory viruses. Oxford, UK, Wiley-Blackwell, 2011, 5: 269-272. |
| Hui P.Y., Lee M.Y., Cheung C.Y., Peiris J.S.M. and Peiris J.S.M., The Role of Innate Sensing Receptors in H5N1 Associated Hyper-induction of Cytokines , Options for the Control of Influenza VII. 2010. |
| Hui P.Y., Lee M.Y., Cheung C.Y., Peiris J.S.M. and Peiris J.S.M., The Role of Innate Sensing Receptors in Highly Pathogenic Avian Influenza (HPAI) H5N1 Associated Hyper-induction of Cytokines, Keystone Symposia: Pathogenesis of Influenza: Virus-Host Interactions. Hong Kong SAR, China, 2011, 129. |
| Hui P.Y., Lee M.Y., Cheung C.Y. and Peiris J.S.M., The role of innate sensing receptors in H5N1 associated hyper-induction of cytokines, INFLUENZA AND OTHER RESPIRATORY VIRUSES. 2011, 5: 269-272. |
| Leung C.Y.H., Nicholls J.M., Sia S.F., Hui P.Y., Cheung P.P.H., Chow C.K., Chan W.Y., Chan M.C.W. and Peiris J.S.M., Toll-like Receptor 3 signaling contributes to enhanced disease severity in H5N1 but not pandemic H1N1 infection in mice, Keystone Symposia on Molecular and Cellular Biology: Pathogenesis of Influenza: virus-host interactions. 2011. |
| Researcher : Hung IFN |
| Project Title: | Harvesting convalescent plasma for hyperimmune intravenous globulin production: a multicentres, randomised double-blind controlled trial for treatment of patients with serious S-OIV H1N1 infection |
| Investigator(s): | Hung IFN, Chan KH, Liang RHS, Lai ST, Yuen KY |
| Department: | Medicine |
| Source(s) of Funding: | Commissioned Studies on Human Swine Influenza Research |
| Start Date: | 08/2009 |
| List of Research Outputs |
| Chan J.F.W., To K.K.W., Tse H., Lau C.Y., Li W.S., Hung I.F.N., Chan K.H., Cheng V.C.C., Lai T.S.T., Woo P.C.Y., Chan E.Y.T. and Yuen K.Y., The lower serum immunoglobulin G2 level in severe cases than in mild cases of pandemic H1N1 2009 influenza is associated with cytokine dysregulation, Clinical and Vaccine Immunology. 2010, 18: 305-310. |
| Chan K.H., To K.K.W., Hung I.F.N., Zhang J., Chan J.F.W., Cheng V.C.C., Tse H., Che X.Y., Chen H. and Yuen K.Y., Differences in antibody responses of individuals with natural infection and those vaccinated against pandemic H1N1 2009 influenza., Clinical Vaccine Immunology. 2011, 18: 867-73. |
| Hung I.F.N., To K.K.W., Lee C.K., Lin C.K., Chan J.F.W., Tse H., Cheng V.C.C., Chen H., Ho P.L., Tse C.W., Ng T.K., Que T.L., Chan K.H. and Yuen K.Y., Effect of Clinical and Virological Parameters on the Level of Neutralizing Antibody against Pandemic Influenza A Virus H1N1 2009, Clin Infect Dis.. 2010, 51: 274-9. |
| Wu J.T.K., Ma S.K., Lee C.K., Chu K.W., Ho P.L., Shen L., Ho W.K., Hung I.F.N., Riley S., Ho L.M., Lin C.K., Tsang T.H.F., Lo S.V., Lau Y.L., Leung G.M., Cowling B.J. and Peiris J.S.M., The infection attack rate and severity of 2009 pandemic H1N1 influenza in Hong Kong, Clinical Infectious Diseases. 2010, 51(10): 1184-1191. |
| Researcher : Im SWK |
| Project Title: | Investigation of community exposure to a novel coronavirus associated with SARS and herd immunity developed among healthy blood donors |
| Investigator(s): | Im SWK, Yam WC |
| Department: | Microbiology |
| Source(s) of Funding: | VCO SARS Research Fund |
| Start Date: | 07/2003 |
| Researcher : Kang SR |
| List of Research Outputs |
| Chan M.C.W., Chan W.Y., Yen H., Yu C.L., Yuen K.M., Tang L.L.S., Li C.L., Kang S.R., Hui F.F., Lai W.W.K., Sihoe A.D.L., Guan Y., Nicholls J.M. and Peiris J.S.M., ) Tropism and innate host response of the 2009 pandemic H1N1 influenza virus compared with related swine influenza viruses and reassortants in ex vivo and in vitro cultures of the human respiratory tract and conjunctiva, Options for the Control of Influenza VII, 2010. |
| Chan M.C.W., Chan W.Y., Yen H., Yu C.L., Yuen K.M., Tang L.L.S., Li C.L., Kang S.R., Hui F.F., Lai W.W.K., Sihoe A.D.L., Guan Y., Nicholls J.M. and Peiris J.S.M., Tropism and innate host response of the 2009 pandemic H2N2 influenza virus compared with related swine influenza viruses and reassortants in ex vivo and in vitro cultures of the human respiratory tract and conjunctiva, Influenza and other respiratory viruses. 2011, 5 (S1): 54-55. |
| Chan W.Y., Kang S.R., Yu C.L. and Chan M.C.W., Effect of vitamin B2 in the treatment of human influenza H5N1 virus infection: studies in vitro and in vivo. , Health Research Symposium 2010. |
| Chan W.Y., Hui F.F., Kang S.R., Yu C.L., Nicholls J.M. and Chan M.C.W., Replication and innate host response of influenza A virus in human lung microvascular endothelial cells: insights into systemic dissemination and pathogenesis , Options for the Control of Influenza VII. 2010. |
| Lee M.Y., Chan W.Y., Gardy D.L., Lo C.K., Sihoe A.D.L., Kang S.R., Cheung K.W., Guan Y., Chan M.C.W., Hancock R.E. and Peiris J.S.M., Systems-level comparison of host responses induced by pandemic and seasonal influenza A H1N1 viruses in primary human type I-like alveolar epithelial cells in vitro, Respiratory Research. 2010, 11: 147. |
| Li C.L., Chan W.Y., Hui F.F., Kang S.R., Yu C.L., Nicholls J.M. and Chan M.C.W., Replication and innate host response of influenza A virus in lung microvascular endothelial cells: new insights into systemic infection and pathogenesis, Influenza and other respiratory viruses. 2011, 5 (S1): 287-288. |
| Yuen K.M., Chan W.Y., Mok K.P., Wong A.C.N., Kang S.R., Nicholls J.M. and Chan M.C.W., Differential onset of apoptosis in avian influenza H5N1 and seasonal H1N1 virus infected human bronchial and alveolar epithelial cell, an in vitro and ex vivo study, Options for the Control of Influenza VII. 2010. |
| Yuen K.M., Chan W.Y., Mok K.P., Wong C.N., Kang S.R., Nicholls J.M. and Chan M.C.W., Differential onset of apoptosis in avian influenza H5N1 and seasonal H1N1 virus infected human bronchial and alveolar epithelial cells: an in vitro and ex vivo study, Influenza and other respiratory viruses. 2011, 5 (S1): 437-438. |
| Researcher : Kao RYT |
| Project Title: | Mode of action of a lead anti-influenza compound identified by chemical genetics |
| Investigator(s): | Kao RYT |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 01/2006 |
| Project Title: | Cloning and characterization of Streptococcus pneumoniae methionine aminopeptidase: a potential target for antimicrobial therapies |
| Investigator(s): | Kao RYT |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 01/2007 |
| Project Title: | Mechanism of novel antagonists of influenza A nucleoprotein trafficking: A chemical genetics approach |
| Investigator(s): | Kao RYT, Chen H, Yang D, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2011 |
| Project Title: | Gordon Research Conference on High-throughput Chemistry and Chemical Biology Identification of new antiviral targets by chemical genetics |
| Investigator(s): | Kao RYT |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 06/2011 |
| Completion Date: | 06/2011 |
| List of Research Outputs |
| Chen Y., Wong R.W.K., Seneviratne C.J., Hagg E.U.O., McGrath C.P.J., Samaranayake L.P. and Kao R.Y.T., The antimicrobial efficacy of Fructus mume extract on orthodontic bracket: A monospecies-biofilm model study in vitro, Archives of Oral Biology. 2010, 56: 16-21. |
| Leung Y.L., Tsui Y.K., Kao R.Y.T., Sun Y., Masuda K., Chan D. and Cheung K.M.C., Modulating proteoglycan metabolisum using small molecules as treatment for disc degeneratioin, World Forum for Spine Research 2010, Montreal, Canada, July 5-8, 2010. |
| Liu W.C., Wong C.T., Fong M.K., Cheung W.S., Kao R.Y.T., Luk K.D.K. and Lu W.W., Gentamicin-loaded strontium-containing hydroxyapatite bioactive bone cement - an efficient bioactive antiobiotic drug delivery system, Journal of Biomedical Materials Research: Part B - Applied Biomaterials. 2010, 95B(2): 397-406. |
| Seneviratne C.J., Wong R.W.K., Hagg E.U.O., Kao R.Y.T. and Samaranayake L.P., Prunus mume extract exhibits antimicrobial activity against pathogenic oral bacteria, International Association for Dental Research (IADR), 88th General Session and Exhibition, Barcelona, Spain, July, 2010 . 2010. |
| Wu S.L., Liu X.M., Yeung C.Y., Yeung K.W.K., Kao R.Y.T., Wu G.S., Hu T., Xu Z.S. and Chu P., Plasma-Modified Biomaterials for Self-Antimicrobial Applications, ACS Applied Materials and Interfaces. 2011. |
| Yeung C.Y., Luk K.D.K., Cheung K.M.C., Yeung K.W.K. and Kao R.Y.T., Antibacterial properties and biocompatibility of novel peptide incorporated titanium alloy biomaterals for orthopaedic implants, 2011. |
| Researcher : Lai ELY |
| List of Research Outputs |
| Ho P.L., Ang L., Chow K.H., Lai E.L.Y. and Chiu S.S.S., The prevalence and characteristics of Streptococcus pneumoniae isolates expressing serotypes 6C and 6D in Hong Kong prior to the introduction of the 7-valent pneumococcal conjugate vaccine , Diagnostic Microbiology and Infectious Disease. 2010. |
| Researcher : Lai WYM |
| List of Research Outputs |
| Tang S.F., Chan J.F.W., Chen M., Tsang O.T.Y., Mok M.Y., Lai W.Y.M., Lee R.A., Que T.L., Tse H., Li W.S., To K.K.W., Cheng V.C.C., Chan E., Zheng B. and Yuen K.Y., Disseminated penicilliosis, recurrent bacteremic non-typhoidal salmonellosis and burkholderiosis associated with acquired immunodeficiency due to autoantibody against interferon gamma., Clin Vaccine Immunol. 2010, 17(7):: 1132-1138. |
| Researcher : Lam HY |
| List of Research Outputs |
| Chen J.H.K., Wong K.H., Chen Z., Chan K.C.W., Lam H.Y., To W.C.S., Cheng V.C.C., Yuen K.Y. and Yam W.C., Increased Genetic Diversity of HIV-1 Circulating in Hong Kong, In: Vlsdimir N., PLoS One. 2010, 5: e12198. |
| Researcher : Lam TY |
| List of Research Outputs |
| Lam T.Y., Zhu H., Wang J., Smith D.K., Holmes E.C., Webster R.G., Webby R., Peiris J.S.M. and Guan Y., Reassortment Events between European Avian-like and American Triple-Reassortant Swine Influenza Viruses in southern China., National Institute of Allergy and Infectious Diseases 5th Annual CEIRS Network Meeting. 2011. |
| Zhu H., Duan L., Li L., Lam T.Y., Wang J., Smith D.K., Peiris J.S.M. and Guan Y., Detection of a novel swine influenza reassortant virus with human infectious potential and inter-species transmissibility from pigs to ferrets. , 40th Keystone Symposia on Molecular and Cellular Biology: Pathogenesis of Influenza: Virus-host Interactions. 2011. |
| Zhu H., Smith D.K., Lam T.Y., Li L., Zheng Z., Chen R., Zheng R., Zeng Y., Zhou J., Wang J., Chen H., Webster R.G., Webby R., Peiris J.S.M. and Guan Y., Reassortants of the pandemic H1N1/2009 virus in swine and their potential to infect human., National Institute of Allergy and Infectious Diseases 5th Annual CEIRS Network Meeting. 2011. |
| Researcher : Lau CY |
| List of Research Outputs |
| Chan J.F.W., To K.K.W., Tse H., Lau C.Y., Li W.S., Hung I.F.N., Chan K.H., Cheng V.C.C., Lai T.S.T., Woo P.C.Y., Chan E.Y.T. and Yuen K.Y., The lower serum immunoglobulin G2 level in severe cases than in mild cases of pandemic H1N1 2009 influenza is associated with cytokine dysregulation, Clinical and Vaccine Immunology. 2010, 18: 305-310. |
| Chan K.H., Zhang J., To K.K.W., Chan C.S., Poon K.M., Guo K., Ng F., Zhang Q., Leung H.C., Cheung A.N.Y., Lau C.Y., Woo P.C.Y., Tse H., Wu W.L., Chen H., Zheng B. and Yuen K.Y., Wild type and mutant 2009 pandemic influenza A (H1N1) viruses cause more severe disease and higher mortality in pregnant BALB/c mice, PLoS One. 2010, 5: e13757. |
| Ho C.C., Lau C.Y., Mertelli P., Chan S.Y., Tse C.W.S., Wu A.K.L., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Novel pan-genomic analysis approach in target selection for multiplex PCR identification and detection of Burkholderia pseudomallei, Burkholderia thailandensis and Burkholderia cepacia complex species: a proof-of-concept study, Journal of Clinical Microbiology. 2011, 49: 814-821. |
| Hung I.F.N., To K.K.W., Lee C...K..., Lee K...L..., Chan K..., Yan W...W..., Liu R..., Watt C...L..., Chan W.M., Lai K...Y..., Koo C...K..., Buckley T..., Chow F...L..., Wong K...K..., Chan H...S..., Ching C...K..., Tang B...S...F..., Lau C.Y., Li W.S., Liu S...H..., Chan K.H., Lin C...K... and Yuen K.Y., Convalescent plasma treatment reduced mortality in patients with severe pandemic influenza A (H1N1) 2009 virus infection , Clinical Infectious Diseases. 2011, 52(4): 447-456. |
| Researcher : Lau S.K.P. |
| Project Title: | The role of bats in the origin of severe acute respiratory syndrome coronavirus |
| Investigator(s): | Lau SKP, Woo PCY, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 07/2007 |
| Project Title: | Genotyping of bat coronavirus HKU9, a novel bat coronavirus identified in Hong Kong |
| Investigator(s): | Lau SKP, Woo PCY, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2009 |
| Completion Date: | 08/2011 |
| Project Title: | The role of a novel rhinovirus species, rhinovirus C, in respiratory illness and its molecular epidemiology |
| Investigator(s): | Lau SKP, Tse H, Woo PCY, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2010 |
| Project Title: | Clinical, phenotypic and molecular characterization of Catabacter hongkongensis recovered from blood cultures of patients |
| Investigator(s): | Lau SKP, Woo PCY, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2010 |
| Project Title: | Molecular characterization of novel animal bocaviruses |
| Investigator(s): | Lau SKP, Woo PCY, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2010 |
| List of Research Outputs |
| Researcher : Lau SKP |
| Project Title: | The role of bats in the origin of severe acute respiratory syndrome coronavirus |
| Investigator(s): | Lau SKP, Woo PCY, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 07/2007 |
| Project Title: | Genotyping of bat coronavirus HKU9, a novel bat coronavirus identified in Hong Kong |
| Investigator(s): | Lau SKP, Woo PCY, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2009 |
| Completion Date: | 08/2011 |
| Project Title: | The role of a novel rhinovirus species, rhinovirus C, in respiratory illness and its molecular epidemiology |
| Investigator(s): | Lau SKP, Tse H, Woo PCY, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2010 |
| Project Title: | Clinical, phenotypic and molecular characterization of Catabacter hongkongensis recovered from blood cultures of patients |
| Investigator(s): | Lau SKP, Woo PCY, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2010 |
| Project Title: | Molecular characterization of novel animal bocaviruses |
| Investigator(s): | Lau SKP, Woo PCY, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2010 |
| List of Research Outputs |
| Curreem S.O.T., Teng L.L., Tse H., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., General metabolism of Laribacter hongkongensis: a genome-wide analysis, Cell & Bioscience. 2011, 1: 16. |
| Ho C.C., Lau C.Y., Mertelli P., Chan S.Y., Tse C.W.S., Wu A.K.L., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Novel pan-genomic analysis approach in target selection for multiplex PCR identification and detection of Burkholderia pseudomallei, Burkholderia thailandensis and Burkholderia cepacia complex species: a proof-of-concept study, Journal of Clinical Microbiology. 2011, 49: 814-821. |
| Lam J.Y.W., Wu A.K.L., Ngai D.C., Teng L.L., Wong E.S.Y., Lau S.K.P., Lee R.A. and Woo P.C.Y., Three cases of severe invasive infections caused by Campylobacter rectus and first report of fatal C rectus infection, Journal of Clinical Microbiology. 2011, 49: 1687-1691. |
| Lau S.K.P. and Woo P.C.Y., Catabacter hongkongensis , Molecular detection of human bacterial pathogens. Taylor and Francis Group, 2011, Chapter 32. |
| Lau S.K.P., Woo P.C.Y., Yip C.Y., Li K.S.M., Fu C.T., Huang Y., Chan K.H. and Yuen K.Y., Co-existence of multiple strains of two novel porcine bocaviruses in the same pig, a previously undescribed phenomenon in members of the family Parvoviridae and evidence for inter- and intra-host genetic diversity and recombination, Journal of General Virology. 2011, 92: 2047-2059. |
| Lau S.K.P., Poon R.W.S., Wong B.H.L., Wang M., Huang Y., Xu H., Guo R., Li K.S.M., Guo K., Chan K.H., Zheng B., Woo P.C.Y. and Yuen K.Y., Coexistence of different genotypes in the same bat and serological characterization of Rousettus bat coronavirus HKU9 belonging to a novel Betacoronavirus subgroup. , J Virol. 2010, 84(21):: 11358-94. |
| Lau S.K.P., Fan Y.Y., Ho C.C., Wong G.K.M., Tsang K.L., Teng L.L., Chen W., Watt R.M., Curreem S.O.T., Tse H., Yuen K.Y. and Woo P.C.Y., Environmental adaptability and stress tolerance of Laribacter hongkongensis: a genome wide analysis, Cell & Bioscience. 2011, 1: 22. |
| Lau S.K.P., Wong G.K.M., Tsang K.L., Teng L.L., Fan Y.Y., Tse H., Yuen K.Y. and Woo P.C.Y., Virulence determinants, drug resistance and mobile genetic elements of Laribacter hongkongensis: a genome-wide analysis, Cell & Bioscience. 2011, 1: 17. |
| To K.K.W., Cheng V.C.C., Chan J.F.W., Wong A.C., Chau S., Tsang F.H.F., Curreem S.O.T., Lau S.K.P., Yuen K.Y. and Woo P.C.Y., Molecular characterization of a catalase-negative Staphylococcus aureus subsp. aureus from a patient with mitral valve endocarditis and pericarditis revealed novel nonsense mutation in katA gene., Journal of Clinical Microbiology. 2011. |
| To K.K.W., Woo P.C.Y., Yuen K.Y. and Lau S.K.P., Molecular characterization of a catalase-negative Staphylococcus aureus subsp. aureus from a patient with mitral valve endocarditis and pericarditis revealed novel nonsense mutation in katA gene., J Clin Microbiol. . 2011. |
| Tse H., Tsoi H.W., Leung A.S.P., Urquhart I.J., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Complete genome sequence of the veterinary pathogen staphylococcus pseudintermedius strain HKU10-03, isolated in a case of canine pyoderma, Journal of Bacteriology. 2011, 193: 1783-1784. |
| Wong S.S.Y., Yip C.Y., Lau S.K.P. and Yuen K.Y., Human enterovirus 71 and hand, foot and mouth disease, Epidemiology and Infection. 2010, 138: 1071-1089. |
| Woo P.C.Y., Lin A.W.C. and Lau S.K.P., Acupuncture transmitted infections, Acupuncture. In Tech-Open Access, 2011. |
| Woo P.C.Y., Ngan H.Y., Chui H.K., Lau S.K.P. and Yuen K.Y., Agar block smear preparation: a novel method of slide preparation for preservation of native fungal structures for microscopic examination and long-term storage, Journal of Clinical Microbiology. 2010, 48: 3053-3061. |
| Woo P.C.Y., Tsang K.L., Wong Y.P., Chen H., Chu J., Lau S.K.P. and Yuen K.Y., Analysis of multilocus sequence typing schemes for 35 different bacteria revealed that gene loci of 10 bacteria could be replaced to improve cost-effectiveness, Diagnostic Microbiology and Infectious Disease. 2011, 70: 316-323. |
| Woo P.C.Y., Teng L.L., Yeung M.Y., Tse H., Lau S.K.P. and Yuen K.Y., Automated identification of medically important bacteria by 16S rRNA gene sequencing using a novel comprehensive database, 16SpathDB, Journal of Clinical Microbiology. 2011, 49: 1799-1809. |
| Woo P.C.Y., Huang Y., Lau S.K.P. and Yuen K.Y., Coronavirus genomics and bioinformatics analysis, Viruses. 2010, 2: 1804-1820. |
| Woo P.C.Y., Tam W.T., Chong T.K., Cai J.J., Tung T.K., Ngan H.Y., Lau S.K.P. and Yuen K.Y., High diversity of polyketide synthase genes and the melanin biosynthesis gene cluster in Penicillium marneffei, FEBS Journal. 2010, 277: 3750-3758. |
| Woo P.C.Y. and Lau S.K.P., Laribacter hongkongensis, Molecular detection of human bacterial pathogens. Taylor and Francis Group, 2011, Chapter 64. |
| Woo P.C.Y., Lau S.K.P., Lee P., Miao J., Fung A.M.Y., Choi K.Y., Ellis-Behnke R.G. and Yuen K.Y., Resequencing microarray for detection of human adenoviruses in patients with community-acquired gastroenteritis: a proof of concept study, Journal of Medical Microbiology. 2010, 59: 1387-1390. |
| Researcher : Lau SY |
| List of Research Outputs |
| Zheng Q., Xia L., Wu W.L., Zheng Z., Huo Y., Wu J., Liu Y., Yu H., Chen Y., Lau S.Y., Chen H., Luo W. and Xia N., Properties and therapeutic efficacy of broadly reactive chimeric and humanized H5-specific monoclonal antibodies against H5N1 influenza viruses, Antimicrobial Agents and Chemotherapy. 2011, 55: 1349-57. |
| Researcher : Lee MY |
| Project Title: | Direct identification and quantification of host and viral microRNAs after influenza infection using the next generation ultra-high throughput DNA sequencer |
| Investigator(s): | Lee MY, Lok S, Cheung CY |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 05/2009 |
| List of Research Outputs |
| Chan M.C.W., Chan W.Y., Yen H., Lee M.Y., Guan Y., Nicholls J.M. and Peiris J.S.M., Comparing the tropism of the pandemic H1N1/2009 influenza virus with seasonal influenza virus, related swine influenza viruses and reassortants in ex vivo and in vitro cultures of human conjunctiva and respiratory tract., 4th Annual Center of Excellence for Influenza Research and Surveillance Network Meeting, Woodcliff Hotel and Conference Center 199 Woodcliff Drive, Fairport, NY 14450 . 2010. |
| Chan M.C.W., Chan W.Y., Lee M.Y., Cheung C.Y., Nicholls J.M. and Peiris J.S.M., Pathogenesis of swine-origin influenza H1N1 virus (S-OIV) in humans: studies of viral tropism and host response in primary differentiated human respiratory epithelial cell cultures in vitro and in ex vivo, Health Research Symposium 2010. |
| Hui P.Y., Lee M.Y., Cheung C.Y., Peiris J.S.M. and Peiris J.S.M., The Role of Innate Sensing Receptors in H5N1 Associated Hyper-induction of Cytokines , Influenza and other respiratory viruses. Oxford, UK, Wiley-Blackwell, 2011, 5: 269-272. |
| Hui P.Y., Lee M.Y., Cheung C.Y., Peiris J.S.M. and Peiris J.S.M., The Role of Innate Sensing Receptors in H5N1 Associated Hyper-induction of Cytokines , Options for the Control of Influenza VII. 2010. |
| Hui P.Y., Lee M.Y., Cheung C.Y., Peiris J.S.M. and Peiris J.S.M., The Role of Innate Sensing Receptors in Highly Pathogenic Avian Influenza (HPAI) H5N1 Associated Hyper-induction of Cytokines, Keystone Symposia: Pathogenesis of Influenza: Virus-Host Interactions. Hong Kong SAR, China, 2011, 129. |
| Hui P.Y., Lee M.Y., Cheung C.Y. and Peiris J.S.M., The role of innate sensing receptors in H5N1 associated hyper-induction of cytokines, INFLUENZA AND OTHER RESPIRATORY VIRUSES. 2011, 5: 269-272. |
| Jia D., Rahbar R., Chan W.Y., Lee M.Y., Chan M.C.W., Wang B.X., Baker D.P., Sun B., Peiris J.S.M., Nicholls J.M. and Fish E.N., Influenza virus non-structural protein 1 (NS1) disrupts interferon signaling. , PLoS One. 2010, 5 (11): e13927. |
| Lee M.Y., Gai W., Cheung K.W. and Peiris J.S.M., Antiviral activity of a selective COX-2 inhibitor NS-398 on avian influenza H5N1 infection, Influenza and other respiratory viruses. Wiley-Blackwell, 2011, 5(Suppl.1): 230-251. |
| Lee M.Y., Gai W., Cheung K.W. and Peiris J.S.M., Antiviral activity of a selective COX-2 inhibitor, NS-398 on avain influenza H5N1 infection., Options for the Control of Influenza VII, 2010. |
| Lee M.Y., Tong A.H.Y., Zhang N., Bao Y. and Lok S., Direct identification and quantification of host and viral microRNAs after influenza infection using the next generation ultra-high throughput DNA sequencer., Health Research Symposium 2010. |
| Lee M.Y., Ng Y.P., Ip N.Y. and Peiris J.S.M., Neuropathogenicity of pandemic H1N1 virus in human astrocytes and neuronal cells., Keystone Symposia, 2011. |
| Lee M.Y., Chan W.Y., Gardy D.L., Lo C.K., Sihoe A.D.L., Kang S.R., Cheung K.W., Guan Y., Chan M.C.W., Hancock R.E. and Peiris J.S.M., Systems-level comparison of host responses induced by pandemic and seasonal influenza A H1N1 viruses in primary human type I-like alveolar epithelial cells in vitro, Respiratory Research. 2010, 11: 147. |
| Ng Y.P., Lee M.Y., Cheung K.W., Nicholls J.M., Peiris J.S.M. and Ip N.Y., Avian influenza H5N1 virus induces cytopathy and proinflammatory cytokine responses in human astrocytic and neuronal cell lines, Neuroscience. 2010, 168(3): 613-23. |
| Researcher : Lee P |
| List of Research Outputs |
| Woo P.C.Y., Lau S.K.P., Lee P., Miao J., Fung A.M.Y., Choi K.Y., Ellis-Behnke R.G. and Yuen K.Y., Resequencing microarray for detection of human adenoviruses in patients with community-acquired gastroenteritis: a proof of concept study, Journal of Medical Microbiology. 2010, 59: 1387-1390. |
| Researcher : Lee RA |
| List of Research Outputs |
| Lam J.Y.W., Wu A.K.L., Ngai D.C., Teng L.L., Wong E.S.Y., Lau S.K.P., Lee R.A. and Woo P.C.Y., Three cases of severe invasive infections caused by Campylobacter rectus and first report of fatal C rectus infection, Journal of Clinical Microbiology. 2011, 49: 1687-1691. |
| Tang S.F., Chan J.F.W., Chen M., Tsang O.T.Y., Mok M.Y., Lai W.Y.M., Lee R.A., Que T.L., Tse H., Li W.S., To K.K.W., Cheng V.C.C., Chan E., Zheng B. and Yuen K.Y., Disseminated penicilliosis, recurrent bacteremic non-typhoidal salmonellosis and burkholderiosis associated with acquired immunodeficiency due to autoantibody against interferon gamma., Clin Vaccine Immunol. 2010, 17(7):: 1132-1138. |
| Researcher : Leung ASP |
| List of Research Outputs |
| Tse H., Tsoi H.W., Leung A.S.P., Urquhart I.J., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Complete genome sequence of the veterinary pathogen staphylococcus pseudintermedius strain HKU10-03, isolated in a case of canine pyoderma, Journal of Bacteriology. 2011, 193: 1783-1784. |
| Researcher : Leung CKL |
| List of Research Outputs |
| Cheung C.Y., Leung C.K.L. and Peiris J.S.M., Potential of the real-time and label-free cell sensor impedance technology to transform cell based infectivity assays for influenza viruses, INFLUENZA AND OTHER RESPIRATORY VIRUSES. 2011, 5: 269-272. |
| Researcher : Leung CSW |
| List of Research Outputs |
| Keng C.T., Akerström S., Leung C.S.W., Poon L.L.M., Peiris J.S.M., Mirazimi A. and Tan Y.J., SARS coronavirus 8b reduces viral replication by down-regulating E via an ubiquitin-independent proteasome pathway., Microbes Infect.. 2011, 13: 2. |
| Researcher : Leung CYH |
| List of Research Outputs |
| Chu Y.C., Cheung C.L., Leung C.Y.H., Poon L.L.M., Chen H., Peiris J.S.M. and Guan Y., Continuing Evolution Of H9n2 Influenza Viruses Endemic In Poultry In Southern China, In: JSM Peiris & Y Guan, Options For The Control of Influenza VII. Oxford, UK, Wiley-Blackwell, 2011, 5 Suppl 1: 68-71. |
| Chu Y.C., Cheung C.L., Leung C.Y.H., Poon L.L.M., Chen H., Peiris J.S.M. and Guan Y., Continuing evolution of H9N2 influenza viruses endemic in poultry in southern China, Influenza Other Respi Viruses. 2011, 5: 68-71. |
| Leung C.Y.H., Cheung P.H.P., Zhang L., Wu Y.O., Chow K.C., Ho C.K., Chow C.K., Ng C.F., Tsang C.L., Dhanasekaran V., Smith G.J., Guan Y. and Peiris J.S.M., Influenza Viruses In Wild Birds In Hong Kong, 2003-2010, In: JSM Peiris & Y Guan, Options For The Control Of Influenza VII. Oxford, UK, Wiley-Blackwell, 2011, 5: 77-78. |
| Leung C.Y.H., Cheung P.P.H., Zhang L., Wu Y.O., Chow K.C., Ho C.K., Chow C.K., Ng C.F., Li C., Tsang C.L., Dhanasekaran V., Smith G.J., Guan Y. and Peiris J.S.M., Influenza viruses in wild birds in Hong Kong, 2003-2010 , Influenza Other Respi Viruses. 2011, 5: 77-78. |
| Leung C.Y.H., Nicholls J.M., Sia S.F., Hui P.Y., Cheung P.P.H., Chow C.K., Chan W.Y., Chan M.C.W. and Peiris J.S.M., Toll-like Receptor 3 signaling contributes to enhanced disease severity in H5N1 but not pandemic H1N1 infection in mice, Keystone Symposia on Molecular and Cellular Biology: Pathogenesis of Influenza: virus-host interactions. 2011. |
| Researcher : Leung HC |
| List of Research Outputs |
| Chan K.H., Zhang J., To K.K.W., Chan C.S., Poon K.M., Guo K., Ng F., Zhang Q., Leung H.C., Cheung A.N.Y., Lau C.Y., Woo P.C.Y., Tse H., Wu W.L., Chen H., Zheng B. and Yuen K.Y., Wild type and mutant 2009 pandemic influenza A (H1N1) viruses cause more severe disease and higher mortality in pregnant BALB/c mice, PLoS One. 2010, 5: e13757. |
| Du L., Leung H.C., Jiang S. and Zheng B., A Recombinant Vaccine of H5N1 HA1 Fused with Foldon and Human IgG Fc Induced Complete Cross-Clade Protection against Divergent H5N1 Viruses. , 1st European Conference of Microbiology and Immunology.. Budapest, Hungary, 2011. |
| Du L., Leung H.C., Zhang X., Zhou J., Chen M., He W., Zhang H., Chan C.S., Poon K.M., Zhao G., Sun S., Cai L., Zhou Y., Zheng B. and Jiang S., A recombinant vaccine of H5N1 HA1 fused with foldon and human IgG Fc induced complete cross-clade protection against divergent H5N1 viruses., PloS One. 2011, 6(1):: e16555. |
| Zheng B., Chan K.H., Zhang J., Zhou J., Chan C.S., Poon K.M., Zhang K., Leung H.C., Jin D., Woo P.C.Y., Chan J.F.W., To K.K.W., Chen H. and Yuen K.Y., D225G mutation in haemagglutinin of pandemic Influenza H1N1 (2009) virus enhances virulence in mice, Experimental Biology and Medicine. 2010, 235: 981-8. |
| Researcher : Leung HC |
| List of Research Outputs |
| Chan K.H., Zhang J., To K.K.W., Chan C.S., Poon K.M., Guo K., Ng F., Zhang Q., Leung H.C., Cheung A.N.Y., Lau C.Y., Woo P.C.Y., Tse H., Wu W.L., Chen H., Zheng B. and Yuen K.Y., Wild type and mutant 2009 pandemic influenza A (H1N1) viruses cause more severe disease and higher mortality in pregnant BALB/c mice, PLoS One. 2010, 5: e13757. |
| Du L., Leung H.C., Jiang S. and Zheng B., A Recombinant Vaccine of H5N1 HA1 Fused with Foldon and Human IgG Fc Induced Complete Cross-Clade Protection against Divergent H5N1 Viruses. , 1st European Conference of Microbiology and Immunology.. Budapest, Hungary, 2011. |
| Du L., Leung H.C., Zhang X., Zhou J., Chen M., He W., Zhang H., Chan C.S., Poon K.M., Zhao G., Sun S., Cai L., Zhou Y., Zheng B. and Jiang S., A recombinant vaccine of H5N1 HA1 fused with foldon and human IgG Fc induced complete cross-clade protection against divergent H5N1 viruses., PloS One. 2011, 6(1):: e16555. |
| Zheng B., Chan K.H., Zhang J., Zhou J., Chan C.S., Poon K.M., Zhang K., Leung H.C., Jin D., Woo P.C.Y., Chan J.F.W., To K.K.W., Chen H. and Yuen K.Y., D225G mutation in haemagglutinin of pandemic Influenza H1N1 (2009) virus enhances virulence in mice, Experimental Biology and Medicine. 2010, 235: 981-8. |
| Researcher : Li C |
| List of Research Outputs |
| Leung C.Y.H., Cheung P.P.H., Zhang L., Wu Y.O., Chow K.C., Ho C.K., Chow C.K., Ng C.F., Li C., Tsang C.L., Dhanasekaran V., Smith G.J., Guan Y. and Peiris J.S.M., Influenza viruses in wild birds in Hong Kong, 2003-2010 , Influenza Other Respi Viruses. 2011, 5: 77-78. |
| Researcher : Li CL |
| List of Research Outputs |
| Chan M.C.W., Chan W.Y., Yen H., Yu C.L., Yuen K.M., Tang L.L.S., Li C.L., Kang S.R., Hui F.F., Lai W.W.K., Sihoe A.D.L., Guan Y., Nicholls J.M. and Peiris J.S.M., ) Tropism and innate host response of the 2009 pandemic H1N1 influenza virus compared with related swine influenza viruses and reassortants in ex vivo and in vitro cultures of the human respiratory tract and conjunctiva, Options for the Control of Influenza VII, 2010. |
| Chan M.C.W., Chan W.Y., Yen H., Yu C.L., Yuen K.M., Tang L.L.S., Li C.L., Kang S.R., Hui F.F., Lai W.W.K., Sihoe A.D.L., Guan Y., Nicholls J.M. and Peiris J.S.M., Tropism and innate host response of the 2009 pandemic H2N2 influenza virus compared with related swine influenza viruses and reassortants in ex vivo and in vitro cultures of the human respiratory tract and conjunctiva, Influenza and other respiratory viruses. 2011, 5 (S1): 54-55. |
| Chan W.Y., Yuen K.M., Yu C.L., Tang L.L.S., Li C.L., Nicholls J.M. and Chan M.C.W., Replication of avian and seasonal influenza viruses in human bronchus and lung, Influenza and other respiratory viruses. 2011, 5: 425-426. |
| Li C.L., Chan W.Y., Hui F.F., Kang S.R., Yu C.L., Nicholls J.M. and Chan M.C.W., Replication and innate host response of influenza A virus in lung microvascular endothelial cells: new insights into systemic infection and pathogenesis, Influenza and other respiratory viruses. 2011, 5 (S1): 287-288. |
| Nicholls J.M., Chan W.Y., Li C.L., Walther T.J. and Haslam S.T.U.A.R.T., Receptors in the Human Respiratory Tract - Making and Breaking the Links, Keystone Symposia on Molecular and Cellular Biology: Pathogenesis of Influenza: virus-host interactions. 2011. |
| Researcher : Li KSM |
| List of Research Outputs |
| Lau S.K.P., Woo P.C.Y., Yip C.Y., Li K.S.M., Fu C.T., Huang Y., Chan K.H. and Yuen K.Y., Co-existence of multiple strains of two novel porcine bocaviruses in the same pig, a previously undescribed phenomenon in members of the family Parvoviridae and evidence for inter- and intra-host genetic diversity and recombination, Journal of General Virology. 2011, 92: 2047-2059. |
| Lau S.K.P., Poon R.W.S., Wong B.H.L., Wang M., Huang Y., Xu H., Guo R., Li K.S.M., Guo K., Chan K.H., Zheng B., Woo P.C.Y. and Yuen K.Y., Coexistence of different genotypes in the same bat and serological characterization of Rousettus bat coronavirus HKU9 belonging to a novel Betacoronavirus subgroup. , J Virol. 2010, 84(21):: 11358-94. |
| Researcher : Li L |
| List of Research Outputs |
| Zhu H., Duan L., Li L., Lam T.Y., Wang J., Smith D.K., Peiris J.S.M. and Guan Y., Detection of a novel swine influenza reassortant virus with human infectious potential and inter-species transmissibility from pigs to ferrets. , 40th Keystone Symposia on Molecular and Cellular Biology: Pathogenesis of Influenza: Virus-host Interactions. 2011. |
| Zhu H., Wang J., Zheng Z., Li L., Duan L., Yip C.H., Peiris J.S.M., Chen H. and Guan Y., Pathogenicity and transmissibility of the pandemic (H1N1) 2009-related influenza viruses in pigs and mice., Options for the Control of Influenza VII. 2010. |
| Zhu H., Wang J., Zheng Z., Chen R., Zheng R., Li L., Duan L., Zhang T., Yip C.H., Yan Z., Chen H., Peiris J.S.M. and Guan Y., Pathogenicity and transmissibility of the pandemic H1N1 2009-related influenza viruses in mice, ferrets, and pigs., Influenza Other Respi Viruses.. 2011, Suppl 1: 82-84. |
| Zhu H., Smith D.K., Lam T.Y., Li L., Zheng Z., Chen R., Zheng R., Zeng Y., Zhou J., Wang J., Chen H., Webster R.G., Webby R., Peiris J.S.M. and Guan Y., Reassortants of the pandemic H1N1/2009 virus in swine and their potential to infect human., National Institute of Allergy and Infectious Diseases 5th Annual CEIRS Network Meeting. 2011. |
| Zhu H., Wang J., Wang P., Song W., Zheng Z., Chen R., Guo K., Zhang T., Duan L., Li L., Yip C.H., Peiris J.S.M., Chen H. and Guan Y., Substitution of E627K in PB2 protein does not change virulence of the 2009 pandemic H1N1 virus in mice., Options for the Control of Influenza VII. 2010. |
| Researcher : Li OTW |
| Project Title: | Genome-wide identification of transcription control influenced by influenza infections |
| Investigator(s): | Li OTW, Poon LLM |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 08/2010 |
| List of Research Outputs |
| Li O.T.W. and Poon L.L.M., DNA intercalator stimulates influenza transcription and virus replication., Virol J. . 2011, 8: 120. |
| Li O.T.W. and Poon L.L.M., Stalling of RNAPIIo by DNA intercalators activates influenza transcription and virus replication., Options for the Control of Influenza VII, 2010, Hong Kong, 2010 . 2010. |
| Mak W.Y., Wong K.S.C., Li O.T.W., Chan K.H., Cheung C.L., Ma S.K., Webby R.I.C.H.A.R.D., Guan Y., Peiris J.S.M. and Poon L.L.M., Rapid genotyping of swine influenza viruses., Emerg Infect Dis.. 2011, 17: 691-694. |
| Yen H., Liang C., Wu C., Forrest H., Ferguson A., Choy K.T., Jones J., Wong D.D.Y., Cheung P.H.P., Hsu C., Li O.T.W., Yuen K.M., Chan W.Y., Poon L.L.M., Chan M.C.W., Nicholls J.M., Krauss S., Wong C.H., Guan Y., Webster R.G., Webby R. and Peiris J.S.M., Hemagglutinin-neuraminidase balance confers respiratory droplet transmissibility of the pandemic H1N1 influenza virus in ferrets, Keystone Symposia (Pathogenesis of Influenza: Virus-Host Interactions), May 23-28, 2011, Hong Kong SAR. 2011. |
| Yen H., Forrest H., Cheung P.P.H., Wong D.D.Y., Li O.T.W., Krauss S., Ferguson A., Crumpton J.C., Jones J., Choy K.T., Ma S.K., Poon L.L.M., Smith G.J., Nicholls J.M., Guan Y., Webster R.G., Webby R. and Peiris J.S.M., Transmissibility of pandemic H1N1 and genetically related swine influenza viruses in ferrets, Influenza Other Respi Viruses. 2011, 5: 85-87. |
| Yen H., Forrest H., Cheung P.P.H., Wong D.D.Y., Li O.T.W., Krauss S., Ferguson A., Crumpton J.C., Jones J., Choy K.T., Ma S.K., Poon L.L.M., Smith G.J., Nicholls J.M., Guan Y., Webster R., Webby R. and Peiris J.S.M., Transmissibility of pandemic H1N1 and genetically related swine influenza viruses in ferrets, Options for the Control of Influenza VII, 2010, Hong Kong. 2010. |
| Researcher : Li WS |
| List of Research Outputs |
| Chan J.F.W., Hwang G.Y., Lamb S., Chan G.S.W., So J.C.C., Leung S.S., To K.K.W., Li W.S., Cheng V.C.C. and Yuen K.Y., Pneumococcal native aortic valve endocarditis with mycotic abdominal aortic aneurysm, paraspinal and iliopsoas abscesses and pneumonia revealing a multiple myeloma, J Med Microbiol. 2011, 60(Pt 6): 851-5. |
| Chan J.F.W., To K.K.W., Tse H., Lau C.Y., Li W.S., Hung I.F.N., Chan K.H., Cheng V.C.C., Lai T.S.T., Woo P.C.Y., Chan E.Y.T. and Yuen K.Y., The lower serum immunoglobulin G2 level in severe cases than in mild cases of pandemic H1N1 2009 influenza is associated with cytokine dysregulation, Clinical and Vaccine Immunology. 2010, 18: 305-310. |
| Cheng V.C.C., Wong L.M., Tai J.W., Chan J.F.W., To K.K.W., Li W.S., Hung I.F.N., Chan K.H., Ho P.L. and Yuen K.Y., Prevention of nosocomial transmission of norovirus by strategic infection control measures, Infection control and hospital epidemiology. 2011, 32(3): 229-37. |
| Cheng V.C.C., Tai J.W.M., Chan W.M., Lau E.H.Y., Chan J.F.W., To K.K.W., Li W.S., Ho P.L. and Yuen K.Y., Sequential introduction of single room isolation and hand hygiene campaign in the control of methicillin-resistant Staphylococcus aureus in intensive care unit., BMC infectious diseases. 2010, 10: 263. |
| Hung I.F.N., To K.K.W., Lee C...K..., Lee K...L..., Chan K..., Yan W...W..., Liu R..., Watt C...L..., Chan W.M., Lai K...Y..., Koo C...K..., Buckley T..., Chow F...L..., Wong K...K..., Chan H...S..., Ching C...K..., Tang B...S...F..., Lau C.Y., Li W.S., Liu S...H..., Chan K.H., Lin C...K... and Yuen K.Y., Convalescent plasma treatment reduced mortality in patients with severe pandemic influenza A (H1N1) 2009 virus infection , Clinical Infectious Diseases. 2011, 52(4): 447-456. |
| Tang S.F., Chan J.F.W., Chen M., Tsang O.T.Y., Mok M.Y., Lai W.Y.M., Lee R.A., Que T.L., Tse H., Li W.S., To K.K.W., Cheng V.C.C., Chan E., Zheng B. and Yuen K.Y., Disseminated penicilliosis, recurrent bacteremic non-typhoidal salmonellosis and burkholderiosis associated with acquired immunodeficiency due to autoantibody against interferon gamma., Clin Vaccine Immunol. 2010, 17(7):: 1132-1138. |
| To K.K.W., Wong S.S.Y., Li W.S., Hung I.F.N., Tse H., Woo P.C.Y., Chan K.H. and Yuen K.Y., Concurrent comparison of epidemiology, clinical presentation and outcome between adult patients suffering from the pandemic influenza A (H1N1) 2009 virus and seasonal influenza A virus infection, Postgrad Med J. 2010. |
| Researcher : Lin Y |
| List of Research Outputs |
| Lin Y., Siu K.L., Tanner J.A. and Zheng B., Antiviral effect of DNA aptamers binding H5N1 virus nucleoprotein., 3rd International Conference on Drug Discovery & Therapy. . Dubai, UAE., 2011. |
| Zhang H., Zheng B., Zhang K., Lin Y., Liao W., Zhang T., Shu D. and Wang S., Low Th17 expression is associated with Chronic Hepatitis B infection by reducing viral specific IFNγ releasing in a HBV transfection model of IL-17 KO mice , In: Dr. Ildiko Rita Dunay, University of Freiburg, Germany Chair of the Scientific Organizing Committee , 1st European Conference of Microbiology and Immunology. European Journal of Microbiology and Immunology . 2011. |
| Zhang N., Lin Y., Chen M., Zhang Q., Cao T. and Zheng B., Swine-Origin Influenza Virus Like Particle Vaccine Conferred Complete Protection Against Lethal Viral Challenge in Balb/C Mice., 1st European Conference of Microbiology and Immunology.. Budapest, Hungary., 2011. |
| Zhao G., Lin Y., Guan J., Du L., Sui H., Chan C.S., Kou Z., Guo Y., Jiang S., Zhou Y. and Zheng B., An M2e-based polypeptide vaccine protects mice from lethal challenge with divergent H5N1 influenza viruses., 4TH Congress of European Microbiologists . Geneva, Switzerland., 2011. |
| Zhao G., Lin Y., Du L., Guan J., He Y., Sun S., Xiao W., Chen M., Chan C.S., Kou Z., Lustigman S., Jiang S., Zheng B. and Zhou Y., Induction of protection against divergent H5N1 influenza viruses using a recombinant fusion protein linking influenza M2e to Onchocerca volvulus activation associated protein-1 (ASP-1) adjuvant., Vaccine. 2010, 28(44):: 7233-40. |
| Zheng B., Lin Y., Shum K.T. and Tanner J.A., DNA aptamers binding H5N1 virus nucleoprotein showed antiviral effects., In: Keystone Symposia: Evolving Approaches to Early-Stage Drug Discovery., Snowbird, Utah, USA, 2011. |
| Zheng B., Du L., Zhao G., Lin Y., Sui H., Chan C.S., He Y., Jiang S., Zhou Y. and Yuen K.Y., SARS-CoV S Protein Induces Strong Mucosal Immune Responses and Provides Long-term Protection Against SARS-CoV Infection., In: Eighth International Symposium on Frontiers in Life Sciences New Advances and Challenges in Multidisciplinary Research., Yinchuan, China., 2010. |
| Researcher : Lin Y |
| List of Research Outputs |
| Lin Y., Siu K.L., Tanner J.A. and Zheng B., Antiviral effect of DNA aptamers binding H5N1 virus nucleoprotein., 3rd International Conference on Drug Discovery & Therapy. . Dubai, UAE., 2011. |
| Zhang H., Zheng B., Zhang K., Lin Y., Liao W., Zhang T., Shu D. and Wang S., Low Th17 expression is associated with Chronic Hepatitis B infection by reducing viral specific IFNγ releasing in a HBV transfection model of IL-17 KO mice , In: Dr. Ildiko Rita Dunay, University of Freiburg, Germany Chair of the Scientific Organizing Committee , 1st European Conference of Microbiology and Immunology. European Journal of Microbiology and Immunology . 2011. |
| Zhang N., Lin Y., Chen M., Zhang Q., Cao T. and Zheng B., Swine-Origin Influenza Virus Like Particle Vaccine Conferred Complete Protection Against Lethal Viral Challenge in Balb/C Mice., 1st European Conference of Microbiology and Immunology.. Budapest, Hungary., 2011. |
| Zhao G., Lin Y., Guan J., Du L., Sui H., Chan C.S., Kou Z., Guo Y., Jiang S., Zhou Y. and Zheng B., An M2e-based polypeptide vaccine protects mice from lethal challenge with divergent H5N1 influenza viruses., 4TH Congress of European Microbiologists . Geneva, Switzerland., 2011. |
| Zhao G., Lin Y., Du L., Guan J., He Y., Sun S., Xiao W., Chen M., Chan C.S., Kou Z., Lustigman S., Jiang S., Zheng B. and Zhou Y., Induction of protection against divergent H5N1 influenza viruses using a recombinant fusion protein linking influenza M2e to Onchocerca volvulus activation associated protein-1 (ASP-1) adjuvant., Vaccine. 2010, 28(44):: 7233-40. |
| Zheng B., Lin Y., Shum K.T. and Tanner J.A., DNA aptamers binding H5N1 virus nucleoprotein showed antiviral effects., In: Keystone Symposia: Evolving Approaches to Early-Stage Drug Discovery., Snowbird, Utah, USA, 2011. |
| Zheng B., Du L., Zhao G., Lin Y., Sui H., Chan C.S., He Y., Jiang S., Zhou Y. and Yuen K.Y., SARS-CoV S Protein Induces Strong Mucosal Immune Responses and Provides Long-term Protection Against SARS-CoV Infection., In: Eighth International Symposium on Frontiers in Life Sciences New Advances and Challenges in Multidisciplinary Research., Yinchuan, China., 2010. |
| Researcher : Lo WU |
| List of Research Outputs |
| Ho P.L., Lo W.U., Yeung M.K., Lin C., Chow K.H., Ang L., Tong A.H.Y., Bao Y., Lok S. and Lo J.Y., Complete sequencing of pNDM-HK encoding NDM-1 carbapenemase from a multidrug-resistant Escherichia coli strain isolated in Hong Kong. , PLoS One. 2011, 6: e17989. |
| Researcher : Ma SK |
| List of Research Outputs |
| Cowling B.J., Ng S., Ma S.K., Cheng K.Y., Lim Wai W.S., Fang J., Chan K.H., Ip D.K.M., Chiu S.S.S., Peiris J.S.M. and Leung G.M., Protective Efficacy of Seasonal Influenza Vaccination against Seasonal and Pandemic Influenza Virus Infection during 2009 in Hong Kong, Clinical Infectious Diseases. 2010, 51(12): 1370-1379. |
| Dhanasekaran V., Smith G.J., Pybus O.G., Zhu H., Bahl J., Poon L.L.M., Riley S., Bahl J., Ma S.K., Cheung C.L., Perera R.A.P.M., Chen H., Shortridge K.F., Webby R., Guan Y. and Peiris J.S.M., Long-term evolution and transmission dynamics of swine influenza A virus., Nature. 2011, 473: 519-22. |
| Lau L.L.H., Chan K.H., Fang J., Cheng K.Y., Ma S.K., Ip D.K.M., Leung G.M., Peiris J.S.M. and Cowling B.J., Baseline hemagglutination inhibition titer levels and protection against naturally acquired influenza virus infection and illness (abstract and poster presentation), HKCCM International Conference, 4-6 September 2010, Hong Kong. Hong Kong, Hong Kong College of Community Medicine, 2010, 60. |
| Ma S.K., Ho P.L., Cheung C.Y., Tse T.M., Dhanasekaran V., Poon L.L.M., Guan Y. and Peiris J.S.M., Surveillance of influenza viruses in swine in Hong Kong abattoir: methods and feasibility, INFLUENZA AND OTHER RESPIRATORY VIRUSES. 2011, 5: 74-76. |
| Mak W.Y., Wong K.S.C., Li O.T.W., Chan K.H., Cheung C.L., Ma S.K., Webby R.I.C.H.A.R.D., Guan Y., Peiris J.S.M. and Poon L.L.M., Rapid genotyping of swine influenza viruses., Emerg Infect Dis.. 2011, 17: 691-694. |
| Ng S., Cheng K.Y., Lim Wai W.S., Fang J., Chan K.H., Ma S.K., Ip D.K.M., Chiu S.S.S., Peiris J.S.M., Leung G.M. and Cowling B.J., Seasonal influenza vaccine and risk of pandemic influenza infection: Findings from a randomized controlled trial (abstract and poster presentation), HKCCM International Conference, 4-6 September 2010, Hong Kong. Hong Kong, Hong Kong College of Community Medicine, 2010, 69. |
| Wu J.T.K., Ma S.K., Lee C.K., Chu K.W., Ho P.L., Shen L., Ho W.K., Hung I.F.N., Riley S., Ho L.M., Lin C.K., Tsang T.H.F., Lo S.V., Lau Y.L., Leung G.M., Cowling B.J. and Peiris J.S.M., A serial cross-sectional serologic survey of 2009 Pandemic (H1N1) in Hong Kong: implications for future pandemic influenza surveillance (Options for the Control of Influenza VII, 3-7 September 2010, Hong Kong), Influenza and Other Respiratory Viruses. 2011, 5(Suppl 1): 190-194. |
| Wu J.T.K., Ma S.K., Lee C.K., Chu K.W., Ho P.L., Shen L., Ho W.K., Hung I.F.N., Riley S., Ho L.M., Lin C.K., Tsang T.H.F., Lo S.V., Lau Y.L., Leung G.M., Cowling B.J. and Peiris J.S.M., The infection attack rate and severity of 2009 pandemic H1N1 influenza in Hong Kong, Clinical Infectious Diseases. 2010, 51(10): 1184-1191. |
| Yen H., Forrest H., Cheung P.P.H., Wong D.D.Y., Li O.T.W., Krauss S., Ferguson A., Crumpton J.C., Jones J., Choy K.T., Ma S.K., Poon L.L.M., Smith G.J., Nicholls J.M., Guan Y., Webster R.G., Webby R. and Peiris J.S.M., Transmissibility of pandemic H1N1 and genetically related swine influenza viruses in ferrets, Influenza Other Respi Viruses. 2011, 5: 85-87. |
| Yen H., Forrest H., Cheung P.P.H., Wong D.D.Y., Li O.T.W., Krauss S., Ferguson A., Crumpton J.C., Jones J., Choy K.T., Ma S.K., Poon L.L.M., Smith G.J., Nicholls J.M., Guan Y., Webster R., Webby R. and Peiris J.S.M., Transmissibility of pandemic H1N1 and genetically related swine influenza viruses in ferrets, Options for the Control of Influenza VII, 2010, Hong Kong. 2010. |
| Zhou Y., Ng M.W., Ma S.K., Ip D.K.M., Kwok H., Ng S., Lau L.L.H., Wu J.T.K., Seto W.H., Leung G.M., Peiris J.S.M. and Cowling B.J., Serologic survey among healthcare worker after first wave of 2009 pandemic H1N1 in Hong Kong (abstract and poster presentation), HKCCM International Conference, 4-6 September 2010, Hong Kong. Hong Kong, Hong Kong College of Community Medicine, 2010, 80. |
| Zhou Y., Ng M.W., Ma S.K., Ip D.K.M., Kwok H., Ng S., Lau L.L.H., Wu J.T.K., Seto W.H., Leung G.M., Peiris J.S.M. and Cowling B.J., Seroprevalence of antibody against 2009 pandemic H1N1 among health care workers in Hong Kong, March-April 2010 (abstract), Options for the Control of Influenza VII Conference, 3-7 September 2010, Hong Kong. Hong Kong, Int’l Society for Influenza & Other Respiratory Virus Dis, 2010, 230. |
| Researcher : Mak WY |
| List of Research Outputs |
| Mak W.Y., Wong K.S.C., Li O.T.W., Chan K.H., Cheung C.L., Ma S.K., Webby R.I.C.H.A.R.D., Guan Y., Peiris J.S.M. and Poon L.L.M., Rapid genotyping of swine influenza viruses., Emerg Infect Dis.. 2011, 17: 691-694. |
| Researcher : Miao J |
| List of Research Outputs |
| Woo P.C.Y., Lau S.K.P., Lee P., Miao J., Fung A.M.Y., Choi K.Y., Ellis-Behnke R.G. and Yuen K.Y., Resequencing microarray for detection of human adenoviruses in patients with community-acquired gastroenteritis: a proof of concept study, Journal of Medical Microbiology. 2010, 59: 1387-1390. |
| Researcher : Mok KP |
| List of Research Outputs |
| Yuen K.M., Chan W.Y., Mok K.P., Wong A.C.N., Kang S.R., Nicholls J.M. and Chan M.C.W., Differential onset of apoptosis in avian influenza H5N1 and seasonal H1N1 virus infected human bronchial and alveolar epithelial cell, an in vitro and ex vivo study, Options for the Control of Influenza VII. 2010. |
| Researcher : Ng CF |
| List of Research Outputs |
| Leung C.Y.H., Cheung P.H.P., Zhang L., Wu Y.O., Chow K.C., Ho C.K., Chow C.K., Ng C.F., Tsang C.L., Dhanasekaran V., Smith G.J., Guan Y. and Peiris J.S.M., Influenza Viruses In Wild Birds In Hong Kong, 2003-2010, In: JSM Peiris & Y Guan, Options For The Control Of Influenza VII. Oxford, UK, Wiley-Blackwell, 2011, 5: 77-78. |
| Leung C.Y.H., Cheung P.P.H., Zhang L., Wu Y.O., Chow K.C., Ho C.K., Chow C.K., Ng C.F., Li C., Tsang C.L., Dhanasekaran V., Smith G.J., Guan Y. and Peiris J.S.M., Influenza viruses in wild birds in Hong Kong, 2003-2010 , Influenza Other Respi Viruses. 2011, 5: 77-78. |
| Researcher : Ng F |
| List of Research Outputs |
| Chan K.H., Zhang J., To K.K.W., Chan C.S., Poon K.M., Guo K., Ng F., Zhang Q., Leung H.C., Cheung A.N.Y., Lau C.Y., Woo P.C.Y., Tse H., Wu W.L., Chen H., Zheng B. and Yuen K.Y., Wild type and mutant 2009 pandemic influenza A (H1N1) viruses cause more severe disease and higher mortality in pregnant BALB/c mice, PLoS One. 2010, 5: e13757. |
| Researcher : Ng IHY |
| List of Research Outputs |
| Tu W., Zheng J., Liu Y., Sia S.F., Liu M., Qin G., Ng I.H.Y., Xiang Z., Lam K.T., Peiris J.S.M. and Lau Y.L., The aminobisphosphonate pamidronate controls influenza pathogenesis by expanding a gammadelta T cell population in humanized mice, Journal of Experimental Medicine. 2011. |
| Researcher : Ng SP |
| Project Title: | Collection of background information on the alternative faecal indicators in the environmental waters of Hong Kong and their correlation with Escherichia coli |
| Investigator(s): | Ng SP, Yam WC |
| Department: | Microbiology |
| Source(s) of Funding: | Environment Protection Department - General Award |
| Start Date: | 06/2001 |
| Researcher : Ngan HY |
| List of Research Outputs |
| To K.K.W., Teng L.L., Wong S.S.Y., Ngan H.Y., Yuen K.Y. and Woo P.C.Y., Complication of corticosteroid treatment by acute Plasmodium malariae infection confirmed by small-subunit rRNA sequencing , Journal of Clinical Microbiology . 2010, 48: 4313-4316. |
| Woo P.C.Y., Ngan H.Y., Chui H.K., Lau S.K.P. and Yuen K.Y., Agar block smear preparation: a novel method of slide preparation for preservation of native fungal structures for microscopic examination and long-term storage, Journal of Clinical Microbiology. 2010, 48: 3053-3061. |
| Woo P.C.Y., Tam W.T., Chong T.K., Cai J.J., Tung T.K., Ngan H.Y., Lau S.K.P. and Yuen K.Y., High diversity of polyketide synthase genes and the melanin biosynthesis gene cluster in Penicillium marneffei, FEBS Journal. 2010, 277: 3750-3758. |
| Researcher : Peiris JSM |
| Project Title: | IV International Symposium on Respiratory Viral Infections The Influenza Disease Burden in Hong Kong: the Rates of Hospitalisation in Children |
| Investigator(s): | Peiris JSM |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 11/2001 |
| Project Title: | Influenza pandemic preparedness in Asia (Research collaboration with national Institute of Allergy and Infectious Diseases (NIAID), St. Jude Children's Research Hospital, Inc. (SJCRH) and The University of Hong Kong) |
| Investigator(s): | Peiris JSM, Guan Y |
| Department: | Microbiology |
| Source(s) of Funding: | National Institutes of Health, US Department of Health and Human Services - General Award |
| Start Date: | 04/2003 |
| Project Title: | Virus-cell interaction and the pathogenesis of SARS |
| Investigator(s): | Peiris JSM |
| Department: | Microbiology |
| Source(s) of Funding: | VCO SARS Research Fund |
| Start Date: | 07/2003 |
| Project Title: | Viral determinants underlying the increased secretion of pro-inflammatory cytokines in H5N1 infected human macrophages: a mechanism for the unusual severity of human H5N1 disease? |
| Investigator(s): | Peiris JSM, Guan Y, Lau ASY, Poon LLM |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2003 |
| Project Title: | The macrophage in the pathogenesis of Severe Acute Respiratory Syndrome Coronavirus infection |
| Investigator(s): | Peiris JSM |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 12/2005 |
| Project Title: | Mass Tag PCR: A novel, multiplex and potentially sensitive approach for the rapid detection of respiratory pathogens |
| Investigator(s): | Peiris JSM, Chiu SSS, Cheung CY |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 06/2006 |
| Project Title: | The pathogenesis of avian influenza A H5N1 in humans: macrophage and epithelial cell-virus interactions in vitro and ex-vivo |
| Investigator(s): | Peiris JSM |
| Department: | Microbiology |
| Source(s) of Funding: | The Wellcome Trust - General Award |
| Start Date: | 01/2007 |
| Project Title: | Communicable Diseases Surveillance and Response (CSR) - Standardization and shipment of PCR diagnostic kit for Avian Influenza detection to Member countries (viz: Bangladesh, Indonesia, Myanmar, Sri Lanka and Thailand) |
| Investigator(s): | Peiris JSM |
| Department: | Microbiology |
| Source(s) of Funding: | Collaborating Project Fund |
| Start Date: | 06/2007 |
| Project Title: | Control of Pandemic and Inter-pandemic Influenza |
| Investigator(s): | Peiris JSM, Guan Y, Yuen KY, Chen H, Leung GM, Lau YL |
| Department: | Microbiology |
| Source(s) of Funding: | Areas of Excellence Scheme |
| Start Date: | 01/2008 |
| Project Title: | Effector roles of cytokine cascades in the pathogenesis of human H5N1 disease |
| Investigator(s): | Peiris JSM, Cheung CY, Lee MY, Nicholls JM |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2008 |
| Project Title: | The role of Toll-like receptor 10 (TLR10) as an innate immune sensor for respiratory viral infections |
| Investigator(s): | Peiris JSM, Lee MY, Nicholls JM |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2011 |
| List of Research Outputs |
| Barber M.R.W., Guan Y., Magor K.E., Peiris J.S.M. and Webster R.G., The role of animal surveillance in influenza preparedness: the consequence of inapparent infection in ducks and pigs, Influenza Other Respi Viruses. 2011, 5: 8-11. |
| Chan M.C.W., Chan W.Y., Yen H., Yu C.L., Yuen K.M., Tang L.L.S., Li C.L., Kang S.R., Hui F.F., Lai W.W.K., Sihoe A.D.L., Guan Y., Nicholls J.M. and Peiris J.S.M., ) Tropism and innate host response of the 2009 pandemic H1N1 influenza virus compared with related swine influenza viruses and reassortants in ex vivo and in vitro cultures of the human respiratory tract and conjunctiva, Options for the Control of Influenza VII, 2010. |
| Chan M.C.W., Chan W.Y., Yen H., Lee M.Y., Guan Y., Nicholls J.M. and Peiris J.S.M., Comparing the tropism of the pandemic H1N1/2009 influenza virus with seasonal influenza virus, related swine influenza viruses and reassortants in ex vivo and in vitro cultures of human conjunctiva and respiratory tract., 4th Annual Center of Excellence for Influenza Research and Surveillance Network Meeting, Woodcliff Hotel and Conference Center 199 Woodcliff Drive, Fairport, NY 14450 . 2010. |
| Chan M.C.W., Chan W.Y., Lee J.W., Fang X., Matthay M.A. and Peiris J.S.M., Impaired alveolar edema fluid clearance in human alveolar epithelial cells injured by severe influenza A virus infection, Keystone Symposia 2011 - Pathogenesis of influenza: virus-host interaction. 2011. |
| Chan M.C.W., Chan W.Y., Lee M.Y., Cheung C.Y., Nicholls J.M. and Peiris J.S.M., Pathogenesis of swine-origin influenza H1N1 virus (S-OIV) in humans: studies of viral tropism and host response in primary differentiated human respiratory epithelial cell cultures in vitro and in ex vivo, Health Research Symposium 2010. |
| Chan M.C.W., Chan W.Y., Yen H., Yu C.L., Yuen K.M., Tang L.L.S., Li C.L., Kang S.R., Hui F.F., Lai W.W.K., Sihoe A.D.L., Guan Y., Nicholls J.M. and Peiris J.S.M., Tropism and innate host response of the 2009 pandemic H2N2 influenza virus compared with related swine influenza viruses and reassortants in ex vivo and in vitro cultures of the human respiratory tract and conjunctiva, Influenza and other respiratory viruses. 2011, 5 (S1): 54-55. |
| Chan W.Y., Chan M.C.W., Li S.Y., Nicholls J.M. and Peiris J.S.M., Neutrophil extracellular trap formation in acute influenza virus infection, Keystone Symposia 2011 - Pathogenesis of influenza: virus-host interaction, 2011 . 2011. |
| Chan W.Y., Chan M.C.W., Nicholls J.M. and Peiris J.S.M., Replication of avian and seasonal influenza viruses in human bronchus and lung, Options for the Control of Influenza VII. 2010. |
| Chan Y.K., Xu M., Ching J.C.Y., Chan V.S.F., Ip Y.C., Yam L., Chu C.M., Lai S.T., So K.M., Wong T.Y., Chung P.H., Tam P., Yip S.P., Sham P.C., Lin C., Leung G.M., Peiris J.S.M. and Khoo U.S., Association of a single nucleotide polymorphism in the CD209 (DC-SIGN) promoter with SARS severity, Hong Kong Med J. 2010, 16(5 Suppl 4): 37-42. |
| Chan Y.K., Xu M.S., Ching C.Y.J., So T.M., Lai S.T., Chu C.M., Yam L.Y., Wong A.T., Chung P.H., Chan V.S.F., Lin C.L., Sham P.C., Leung G.M., Peiris J.S.M. and Khoo U.S., CD209 (DC-SIGN) -336A>G promoter polymorphism and severe acute respiratory syndrome in Hong Kong Chinese, Hum Immunol. 2010, 71(7): 702-7. |
| Cheung C.Y., Leung C.K.L. and Peiris J.S.M., Potential of the real-time and label-free cell sensor impedance technology to transform cell based infectivity assays for influenza viruses, INFLUENZA AND OTHER RESPIRATORY VIRUSES. 2011, 5: 269-272. |
| Chiu S.S.S., Chan K.H., Wong W.H.S., Chan L.Y. and Peiris J.S.M., Age-matched comparison of children hospitalized for 2009 pandemic H1N1 influenza with those hospitalized for seasonal H1N1 and H3N2, PLoS ONE. 2011, 6 (7): e21837. |
| Chiu S.S.S., Chan K.H., Chen H., Young B.W.Y., Lim W., Wong W.H.S. and Peiris J.S.M., Virologically confirmed population-based burden of hospitalization caused by respiratory syncytial virus, adenovirus, and parainfluenza viruses in children in Hong Kong, The Pediatric Infectious Disease Journal [Epub ahead]. 2010, 29(12). |
| Chu K.W., Chin W.H., Smith G.J., Chan K.H., Guan Y., Peiris J.S.M. and Poon L.L.M., Detection of novel astroviruses in urban brown rats and previously known astroviruses in humans., J Gen Virol. . 2010, 91: 2457-2462. |
| Chu Y.C., Cheung C.L., Leung C.Y.H., Poon L.L.M., Chen H., Peiris J.S.M. and Guan Y., Continuing Evolution Of H9n2 Influenza Viruses Endemic In Poultry In Southern China, In: JSM Peiris & Y Guan, Options For The Control of Influenza VII. Oxford, UK, Wiley-Blackwell, 2011, 5 Suppl 1: 68-71. |
| Chu Y.C., Cheung C.L., Leung C.Y.H., Poon L.L.M., Chen H., Peiris J.S.M. and Guan Y., Continuing evolution of H9N2 influenza viruses endemic in poultry in southern China, Influenza Other Respi Viruses. 2011, 5: 68-71. |
| Chye M.L., Li H., Ramalingam S., Poon L.L.M. and Peiris J.S.M., Genetically modified plants comprising SARS-CoV viral nucleotide sequences and methods of use thereof for immunization against SARS., Chinese Patent No. z1200480039355.6 issued on Aug 4 . 2010. |
| Cook A.R., Fang J., Leung G.M., Peiris J.S.M. and Cowling B.J., Association between influenza A viral shedding and infectivity in households (abstract), Options for the Control of Influenza VII Conference, 3-7 September 2010, Hong Kong. Hong Kong, Int’l Society for Influenza & Other Respiratory Virus Dis, 2010. |
| Cowling B.J., Ng S., Ma S.K., Cheng K.Y., Lim Wai W.S., Fang J., Chan K.H., Ip D.K.M., Chiu S.S.S., Peiris J.S.M. and Leung G.M., Protective Efficacy of Seasonal Influenza Vaccination against Seasonal and Pandemic Influenza Virus Infection during 2009 in Hong Kong, Clinical Infectious Diseases. 2010, 51(12): 1370-1379. |
| Cowling B.J., Ng S., Ip D.K.M., Peiris J.S.M. and Leung G.M., Reply to Skowronski (letter), Clinical Infectious Diseases. 2011, 52(6): 832-833. |
| Cowling B.J., Ng S., Cheng K.Y., Wai W., Fang J., Chan K., Ma E., Ip D.K.M., Chiu S.S.S., Peiris J.S.M. and Leung G.M., The effectiveness of seasonal influenza vaccine in preventing pandemic and seasonal influenza infection: A randomized controlled trial (abstract), Options for the Control of Influenza VII Conference, 3-7 September 2010, Hong Kong. Hong Kong, Int’l Society for Influenza & Other Respiratory Virus Dis, 2010, 79-80. |
| Cowling B.J., Ng S., Cheng K.Y., Lim Wai W.S., Fang J., Chan K.H., Ma E.S.K., Ip D.K.M., Chiu S.S.S., Peiris J.S.M. and Leung G.M., The effectiveness of seasonal influenza vaccine in preventing pandemic and seasonal influenza infection: a randomized controlled trial (Options for the Control of Influenza VII, 3-7 September 2010, Hong Kong), Influenza and Other Respiratory Viruses. 2010, 5(Suppl 1): 328-332. |
| Dhanasekaran V., Smith G.J., Pybus O.G., Zhu H., Bahl J., Poon L.L.M., Riley S., Bahl J., Ma S.K., Cheung C.L., Perera R.A.P.M., Chen H., Shortridge K.F., Webby R., Guan Y. and Peiris J.S.M., Long-term evolution and transmission dynamics of swine influenza A virus., Nature. 2011, 473: 519-22. |
| Duan L., Zhu H., Wang J., Huang K., Cheung C.L., Peiris J.S.M., Chen H. and Guan Y., Influenza virus surveillance in migratory ducks and sentinel ducks at Poyang Lake, China., Influenza Other Respi Viruses. . 2011, Suppl 1: 65-68. |
| Duan L., Zhu H., Huang K., Wang J., Cheung C.L., Peiris J.S.M., Chen H. and Guan Y., Influenza virus surveillance in migratory ducks and sentinel ducks at Poyang Lake, China., Options for the Control of Influenza VII. 2010. |
| Fang J., Cook A.R., Leung G.M., Peiris J.S.M. and Cowling B.J., Inferring influenza A infection attack rates from serologic data allowing for cross-reactive antibody responses (abstract), Options for the Control of Influenza VII Conference, 3-7 September 2010, Hong Kong. Hong Kong, Int’l Society for Influenza & Other Respiratory Virus Dis, 2010, 229. |
| Huang K., Bahl J., Fan X... .H..., Dhanasekaran V., Cheung C.L., Webby R... .J..., Webster R... .G..., Chen H., Smith G.J., Peiris J.S.M. and Guan Y., Establishment of an H6N2 Influenza Virus Lineage in Domestic Ducks in Southern China., J Virol. 2010, 84: 6978-86. |
| Huang K., Cheung C.L., Fan X., Zhu H., Wang J., Duan L., Webby R., Webster R., Chen H., Peiris J.S.M. and Guan Y., Interspecies transmission and lineage replacement of H6 subtype influenza viruses in Southern China. , Options for the Control of Influenza VII. 2010. |
| Hui P.Y., Lee M.Y., Cheung C.Y., Peiris J.S.M. and Peiris J.S.M., The Role of Innate Sensing Receptors in H5N1 Associated Hyper-induction of Cytokines , Influenza and other respiratory viruses. Oxford, UK, Wiley-Blackwell, 2011, 5: 269-272. |
| Hui P.Y., Lee M.Y., Cheung C.Y., Peiris J.S.M. and Peiris J.S.M., The Role of Innate Sensing Receptors in H5N1 Associated Hyper-induction of Cytokines , Options for the Control of Influenza VII. 2010. |
| Hui P.Y., Lee M.Y., Cheung C.Y., Peiris J.S.M. and Peiris J.S.M., The Role of Innate Sensing Receptors in Highly Pathogenic Avian Influenza (HPAI) H5N1 Associated Hyper-induction of Cytokines, Keystone Symposia: Pathogenesis of Influenza: Virus-Host Interactions. Hong Kong SAR, China, 2011, 129. |
| Hui P.Y., Lee M.Y., Cheung C.Y. and Peiris J.S.M., The role of innate sensing receptors in H5N1 associated hyper-induction of cytokines, INFLUENZA AND OTHER RESPIRATORY VIRUSES. 2011, 5: 269-272. |
| Jia D., Rahbar R., Chan W.Y., Lee M.Y., Chan M.C.W., Wang B.X., Baker D.P., Sun B., Peiris J.S.M., Nicholls J.M. and Fish E.N., Influenza virus non-structural protein 1 (NS1) disrupts interferon signaling. , PLoS One. 2010, 5 (11): e13927. |
| Keng C.T., Akerström S., Leung C.S.W., Poon L.L.M., Peiris J.S.M., Mirazimi A. and Tan Y.J., SARS coronavirus 8b reduces viral replication by down-regulating E via an ubiquitin-independent proteasome pathway., Microbes Infect.. 2011, 13: 2. |
| Khoo U.S., Ching J.C.Y., Chan Y.K., Xu M., So K.M., Lai S.T., Chu C.M., Yam L., Wong T.Y., Chung P.H., Chan V.S.F., Tam P.K.H., Yip S.P., Lin C.L., Sham P.C., Leung G.M. and Peiris J.S.M., The CD209 (DC-SIGN) -336A>G and MxA -123C>A promoter polymorphisms in Severe Acute Respiratory Syndrome Coronavirus infection in Hong Kong Chinese, Health Research Symposium 2010: “Improving health and recognising excellence, Hong Kong. 2010. |
| Lam T.Y., Zhu H., Wang J., Smith D.K., Holmes E.C., Webster R.G., Webby R., Peiris J.S.M. and Guan Y., Reassortment Events between European Avian-like and American Triple-Reassortant Swine Influenza Viruses in southern China., National Institute of Allergy and Infectious Diseases 5th Annual CEIRS Network Meeting. 2011. |
| Lau L.H.L., Fang J., Chan K.H., Cheng K.Y., Peiris J.S.M., Leung G.M. and Cowling B.J., Patterns of viral shedding in pandemic and seasonal influenza virus infections in a community setting (Options for the Control of Influenza VII, 3-7 September 2010, Hong Kong), Influenza and Other Respiratory Viruses. 2010, 5(Suppl 1): 301-303. |
| Lau L.L.H., Chan K.H., Fang J., Cheng K.Y., Ma E.S.K., Ip D.K.M., Leung G.M., Peiris J.S.M. and Cowling B.J., Association of antibody titer measured by hemagglutination inhibition with protection from influenza virus infection and illness in a community setting (abstract), Options for the Control of Influenza VII Conference, 3-7 September 2010, Hong Kong. Hong Kong, Int’l Society for Influenza & Other Respiratory Virus Dis, 2010, 231. |
| Lau L.L.H., Chan K.H., Fang J., Cheng K.Y., Ma S.K., Ip D.K.M., Leung G.M., Peiris J.S.M. and Cowling B.J., Baseline hemagglutination inhibition titer levels and protection against naturally acquired influenza virus infection and illness (abstract and poster presentation), HKCCM International Conference, 4-6 September 2010, Hong Kong. Hong Kong, Hong Kong College of Community Medicine, 2010, 60. |
| Lau L.L.H., Fang J., Chan K., Cheng K.Y., Peiris J.S.M., Leung G.M. and Cowling B.J., Patterns of viral shedding in pandemic and seasonal influenza virus infections in a community setting (abstract), Options for the Control of Influenza VII Conference, 3-7 September 2010, Hong Kong. Hnog Kong, Int’l Society for Influenza & Other Respiratory Virus Dis, 2010, 70. |
| Lee M.Y., Gai W., Cheung K.W. and Peiris J.S.M., Antiviral activity of a selective COX-2 inhibitor NS-398 on avian influenza H5N1 infection, Influenza and other respiratory viruses. Wiley-Blackwell, 2011, 5(Suppl.1): 230-251. |
| Lee M.Y., Gai W., Cheung K.W. and Peiris J.S.M., Antiviral activity of a selective COX-2 inhibitor, NS-398 on avain influenza H5N1 infection., Options for the Control of Influenza VII, 2010. |
| Lee M.Y., Ng Y.P., Ip N.Y. and Peiris J.S.M., Neuropathogenicity of pandemic H1N1 virus in human astrocytes and neuronal cells., Keystone Symposia, 2011. |
| Lee M.Y., Chan W.Y., Gardy D.L., Lo C.K., Sihoe A.D.L., Kang S.R., Cheung K.W., Guan Y., Chan M.C.W., Hancock R.E. and Peiris J.S.M., Systems-level comparison of host responses induced by pandemic and seasonal influenza A H1N1 viruses in primary human type I-like alveolar epithelial cells in vitro, Respiratory Research. 2010, 11: 147. |
| Lee S.L., Chiu S.S.S., Peiris J.S.M., Chan K.H., Wong W.H.S. and Lau Y.L., Is respiratory viral infection really an important trigger of asthma exacerbations in children?, Eur J Pediatr [Epub ahead]. 2011. |
| Leung C.Y.H., Cheung P.H.P., Zhang L., Wu Y.O., Chow K.C., Ho C.K., Chow C.K., Ng C.F., Tsang C.L., Dhanasekaran V., Smith G.J., Guan Y. and Peiris J.S.M., Influenza Viruses In Wild Birds In Hong Kong, 2003-2010, In: JSM Peiris & Y Guan, Options For The Control Of Influenza VII. Oxford, UK, Wiley-Blackwell, 2011, 5: 77-78. |
| Leung C.Y.H., Cheung P.P.H., Zhang L., Wu Y.O., Chow K.C., Ho C.K., Chow C.K., Ng C.F., Li C., Tsang C.L., Dhanasekaran V., Smith G.J., Guan Y. and Peiris J.S.M., Influenza viruses in wild birds in Hong Kong, 2003-2010 , Influenza Other Respi Viruses. 2011, 5: 77-78. |
| Leung C.Y.H., Nicholls J.M., Sia S.F., Hui P.Y., Cheung P.P.H., Chow C.K., Chan W.Y., Chan M.C.W. and Peiris J.S.M., Toll-like Receptor 3 signaling contributes to enhanced disease severity in H5N1 but not pandemic H1N1 infection in mice, Keystone Symposia on Molecular and Cellular Biology: Pathogenesis of Influenza: virus-host interactions. 2011. |
| Ma S.K., Ho P.L., Cheung C.Y., Tse T.M., Dhanasekaran V., Poon L.L.M., Guan Y. and Peiris J.S.M., Surveillance of influenza viruses in swine in Hong Kong abattoir: methods and feasibility, INFLUENZA AND OTHER RESPIRATORY VIRUSES. 2011, 5: 74-76. |
| Mak W.Y., Wong K.S.C., Li O.T.W., Chan K.H., Cheung C.L., Ma S.K., Webby R.I.C.H.A.R.D., Guan Y., Peiris J.S.M. and Poon L.L.M., Rapid genotyping of swine influenza viruses., Emerg Infect Dis.. 2011, 17: 691-694. |
| Ng S., Cheng K.Y., Lim Wai W.S., Fang J., Chan K.H., Ma S.K., Ip D.K.M., Chiu S.S.S., Peiris J.S.M., Leung G.M. and Cowling B.J., Seasonal influenza vaccine and risk of pandemic influenza infection: Findings from a randomized controlled trial (abstract and poster presentation), HKCCM International Conference, 4-6 September 2010, Hong Kong. Hong Kong, Hong Kong College of Community Medicine, 2010, 69. |
| Peiris J.S.M., Chairman, The Options for the Control of Influenza VII Conferences. 2010. |
| Peiris J.S.M., Co-organizer., Keystone Symposia - Pathogeneis of Influenza: Virus-Host Interactions in Hong Kong May 23-27, 2011.. 2011. |
| Peiris J.S.M., Comparative Epidemiology of Pandemic and Seasonal Influenza A in Households in The New England Journal of Medicine. 2010 Jun 10; 362(23):2175-84., 2011 Faculty Outstanding Research Output Award. 2011. |
| Peiris J.S.M. and Poon L.L.M., Detection of SARS coronavirus., Methods Mol Biol. . 2011, 665: 369-82. |
| Peiris J.S.M., Chan M.C.W., Chan W.Y. and Nicholls J.M., Human ex vivo and in vitro Experimental Models for Studying Influenza Pathogenesis, Keystone Symposia on Molecular and Cellular Biology: Pathogenesis of Influenza: virus-host interactions. 2011. |
| Peiris J.S.M., Invited for Technical presentations "Surveillance of influenza viruses in swine in a Hong Kong abattoir"., OFFLU Annual Technical Meeting, Room, Italy. 2010. |
| Peiris J.S.M., Invited lecture: Human ex-vivo and in-vitro Experimental Models for Studying Influenza Pathogenesis., Keystone Symposia. Human Disease, Lung Injury and Human-Cell Experimental Models. . 2011. |
| Peiris J.S.M., Invited lecture: Plagues past, present and future., The Hong Kong Academy of Hong Kong: 2010 David Todd Oration.. 2010. |
| Peiris J.S.M., Invited talk., Musee du quai Branly talk, Paris, France. 2011. |
| Peiris J.S.M., Scientific Advisory Board., XIII International Symposium on Respiratory Viral Infections. Rome, Italy, Mar. 14-16, 2011.. 2011. |
| Peiris J.S.M., Session I - Minisymposium: Animal / Human Interface: Invited lecture and panel discussion: Surveillance of Influenza in pigs, XIII International Symposium on Respiratory Viral Infections.. 2011. |
| Peiris J.S.M., Session III Pathogenesis - Literature Review: Pre-clinical SARS and Influenza., XIII International Symposium on Respiratory Viral Infections.. 2011. |
| Riley S., Kwok K.O., Wu K.M., Ning Y., Cowling B.J., Wu J.T.K., Ho L.M., Tsang T.H.F., Lo S.V., Chu K.W., Ma E.S.K. and Peiris J.S.M., Epidemiological characteristics of 2009 (H1N1) pandemic influenza based on paired sera from a longitudinal community cohort study, PLoS Medicine. 2011, 8(6): e1000442. |
| Tu W., Mao H., Zheng J., Liu Y., Chiu S.S.S., Qin G., Chan P.L., Lam K.T., Guan J., Zhang L., Guan Y., Yuen K.Y., Peiris J.S.M. and Lau Y.L., Cytotoxic T Lymphocytes Established by Seasonal Human Influenza Cross-react against 2009 Pandemic H1N1 Influenza Virus., Journal of Virology. 2010, 84: 6527-35. |
| Tu W., Mao H., Zheng J., Liu Y., Chiu S.S.S., Qin G., Chan P.L., Lam K.T., Guan J., Zhang L., Guan Y., Yuen K.Y., Peiris J.S.M. and Lau Y.L., Cytotoxic T lymphocytes established by seasonal human influenza cross-react against 2009 pandemic H1N1 influenza virus, J Virol. 2010, 84(13): 6527-35. |
| Tu W., Zheng J., Liu Y., Sia S.F., Liu M., Qin G., Ng I.H.Y., Xiang Z., Lam K.T., Peiris J.S.M. and Lau Y.L., The aminobisphosphonate pamidronate controls influenza pathogenesis by expanding a gammadelta T cell population in humanized mice, Journal of Experimental Medicine. 2011. |
| Wong C.M., Yang L., Chan K.P., Ma S.S.L., He J.F., Chen P.Y., Chan K.H. and Peiris J.S.M., Disease burden of influenza in three tropic and sub-tropic cities in Asia (abstract), Options for the Control of Influenza VII Conference, 3-7 September 2010, Hong Kong. Hong Kong, Int’l Society for Influenza & Other Respiratory Virus Dis, 2010, 229-230. |
| Wong C.M., Thach T.Q., Chau Y.K., Chan K.P., Chung R.Y.N., Ou C., Yang L., Peiris J.S.M., Thomas G.N., Lam T.H., Wong T.W. and Hedley A.J., Interaction between air pollution and respiratory viruses: Time-series study of daily mortality and hospital admissions in Hong Kong, Public Health and Air Pollution in Asia (PAPA): Coordinated Studies of Short-Term Exposure to Air Pollution and Daily Mortality in Four Cities Report # 154. Boston, USA, Health Effects Institute, 2010, Part 4: 283-372. |
| Wong C.M., Thach T.Q., Chau Y.K., Chan K.P., Chung R.Y.N., Ou C., Yang L., Peiris J.S.M., Thomas G.N., Lam T.H., Wong T.W. and Hedley A.J., Public health and air pollution in Asia (PAPA): A combined analysis of four studies of air pollution and mortality, Public Health and Air Pollution in Asia (PAPA): Coordinated Studies of Short-Term Exposure to Air Pollution and Daily Mortality in Four Cities Report # 154. Boston, USA, Health Effects Institute, 2010, Part 5: 377-431. |
| Wong H.M.E., Smith D.K., Rabadan R., Peiris J.S.M. and Poon L.L.M., Codon usage bias and the evolution of influenza A viruses. Codon Usage Biases of Influenza Virus., BMC Evol Biol. . 2010, 10: 253. |
| Wu J.T.K., Ma S.K., Lee C.K., Chu K.W., Ho P.L., Shen L., Ho W.K., Hung I.F.N., Riley S., Ho L.M., Lin C.K., Tsang T.H.F., Lo S.V., Lau Y.L., Leung G.M., Cowling B.J. and Peiris J.S.M., A serial cross-sectional serologic survey of 2009 Pandemic (H1N1) in Hong Kong: implications for future pandemic influenza surveillance (Options for the Control of Influenza VII, 3-7 September 2010, Hong Kong), Influenza and Other Respiratory Viruses. 2011, 5(Suppl 1): 190-194. |
| Wu J.T.K., Cowling B.J., Riley S., Peiris J.S.M., Ma E., Lee K., Hung I.F.N., Lau Y.L., Lo S.V. and Leung G.M., A serial cross-sectional serologic survey of 2009 pandemic (H1N1) in Hong Kong: Implications for future pandemic influenza surveillance (abstract), Options for the Control of Influenza VII Conference, 3-7 September 2010, Hong Kong. Hong Kong, Int’l Society for Influenza & Other Respiratory Virus Dis, 2010, 256. |
| Wu J.T.K., Ma S.K., Lee C.K., Chu K.W., Ho P.L., Shen L., Ho W.K., Hung I.F.N., Riley S., Ho L.M., Lin C.K., Tsang T.H.F., Lo S.V., Lau Y.L., Leung G.M., Cowling B.J. and Peiris J.S.M., The infection attack rate and severity of 2009 pandemic H1N1 influenza in Hong Kong, Clinical Infectious Diseases. 2010, 51(10): 1184-1191. |
| Yang L., Chiu S.S.S., Chan K.P., Wong W.H.S., Peiris J.S.M. and Wong C.M., Validating statistical models for estimating disease burden of influenza and other respiratory viruses using virologically confirmed data (oral presentation), Options for the Control of Influenza VII Conference, 3-7 September 2010, Hong Kong. Hong Kong, Int’l Society for Influenza & Other Respiratory Virus Dis, 2010, 36. |
| Yang L., Chiu S.S.S., Chan K.P., Chan K.H., Wong W.H.S., Peiris J.S.M. and Wong C.M., Validation of statistical models for estimating hospitalization associated with influenza and other respiratory viruses, PLoS One. 2011, 6(3): e17882. |
| Yen H., Liang C., Wu C., Forrest H., Ferguson A., Choy K.T., Jones J., Wong D.D.Y., Cheung P.H.P., Hsu C., Li O.T.W., Yuen K.M., Chan W.Y., Poon L.L.M., Chan M.C.W., Nicholls J.M., Krauss S., Wong C.H., Guan Y., Webster R.G., Webby R. and Peiris J.S.M., Hemagglutinin-neuraminidase balance confers respiratory droplet transmissibility of the pandemic H1N1 influenza virus in ferrets, Keystone Symposia (Pathogenesis of Influenza: Virus-Host Interactions), May 23-28, 2011, Hong Kong SAR. 2011. |
| Yen H., Forrest H., Cheung P.P.H., Wong D.D.Y., Li O.T.W., Krauss S., Ferguson A., Crumpton J.C., Jones J., Choy K.T., Ma S.K., Poon L.L.M., Smith G.J., Nicholls J.M., Guan Y., Webster R.G., Webby R. and Peiris J.S.M., Transmissibility of pandemic H1N1 and genetically related swine influenza viruses in ferrets, Influenza Other Respi Viruses. 2011, 5: 85-87. |
| Yen H., Forrest H., Cheung P.P.H., Wong D.D.Y., Li O.T.W., Krauss S., Ferguson A., Crumpton J.C., Jones J., Choy K.T., Ma S.K., Poon L.L.M., Smith G.J., Nicholls J.M., Guan Y., Webster R., Webby R. and Peiris J.S.M., Transmissibility of pandemic H1N1 and genetically related swine influenza viruses in ferrets, Options for the Control of Influenza VII, 2010, Hong Kong. 2010. |
| Yu C.L., Chan W.Y., Wang J., Nicholls J.M., Peiris J.S.M., Mason R.J. and Chan M.C.W., Avian influenza H5N1 and seasonal H1N1 virus infection and innate host responses in human alveolar type II epithelial cells and macrophages, Options for the Control of Influenza VII. 2010. |
| Zhou Y., Ng M.W., Ma S.K., Ip D.K.M., Kwok H., Ng S., Lau L.L.H., Wu J.T.K., Seto W.H., Leung G.M., Peiris J.S.M. and Cowling B.J., Serologic survey among healthcare worker after first wave of 2009 pandemic H1N1 in Hong Kong (abstract and poster presentation), HKCCM International Conference, 4-6 September 2010, Hong Kong. Hong Kong, Hong Kong College of Community Medicine, 2010, 80. |
| Zhou Y., Ng M.W., Ma S.K., Ip D.K.M., Kwok H., Ng S., Lau L.L.H., Wu J.T.K., Seto W.H., Leung G.M., Peiris J.S.M. and Cowling B.J., Seroprevalence of antibody against 2009 pandemic H1N1 among health care workers in Hong Kong, March-April 2010 (abstract), Options for the Control of Influenza VII Conference, 3-7 September 2010, Hong Kong. Hong Kong, Int’l Society for Influenza & Other Respiratory Virus Dis, 2010, 230. |
| Zhu H., Duan L., Li L., Lam T.Y., Wang J., Smith D.K., Peiris J.S.M. and Guan Y., Detection of a novel swine influenza reassortant virus with human infectious potential and inter-species transmissibility from pigs to ferrets. , 40th Keystone Symposia on Molecular and Cellular Biology: Pathogenesis of Influenza: Virus-host Interactions. 2011. |
| Zhu H., Wang J., Chen H., Webster R., Webby R., Peiris J.S.M. and Guan Y., Influenza surveillance program in swine in Southern China (Dec 2009-Jun 2010), National Institute of Allergy and Infectious Diseases 4th Annual CEIRS Network Meeting. 2010. |
| Zhu H., Wang J., Zheng Z., Li L., Duan L., Yip C.H., Peiris J.S.M., Chen H. and Guan Y., Pathogenicity and transmissibility of the pandemic (H1N1) 2009-related influenza viruses in pigs and mice., Options for the Control of Influenza VII. 2010. |
| Zhu H., Wang J., Zheng Z., Chen R., Zheng R., Li L., Duan L., Zhang T., Yip C.H., Yan Z., Chen H., Peiris J.S.M. and Guan Y., Pathogenicity and transmissibility of the pandemic H1N1 2009-related influenza viruses in mice, ferrets, and pigs., Influenza Other Respi Viruses.. 2011, Suppl 1: 82-84. |
| Zhu H., Smith D.K., Lam T.Y., Li L., Zheng Z., Chen R., Zheng R., Zeng Y., Zhou J., Wang J., Chen H., Webster R.G., Webby R., Peiris J.S.M. and Guan Y., Reassortants of the pandemic H1N1/2009 virus in swine and their potential to infect human., National Institute of Allergy and Infectious Diseases 5th Annual CEIRS Network Meeting. 2011. |
| Zhu H., Wang J., Wang P., Song W., Zheng Z., Chen R., Guo K., Zhang T., Duan L., Li L., Yip C.H., Peiris J.S.M., Chen H. and Guan Y., Substitution of E627K in PB2 protein does not change virulence of the 2009 pandemic H1N1 virus in mice., Options for the Control of Influenza VII. 2010. |
| Researcher : Perera RAPM |
| List of Research Outputs |
| Dhanasekaran V., Smith G.J., Pybus O.G., Zhu H., Bahl J., Poon L.L.M., Riley S., Bahl J., Ma S.K., Cheung C.L., Perera R.A.P.M., Chen H., Shortridge K.F., Webby R., Guan Y. and Peiris J.S.M., Long-term evolution and transmission dynamics of swine influenza A virus., Nature. 2011, 473: 519-22. |
| Researcher : Poon KM |
| List of Research Outputs |
| Chan K.H., Zhang J., To K.K.W., Chan C.S., Poon K.M., Guo K., Ng F., Zhang Q., Leung H.C., Cheung A.N.Y., Lau C.Y., Woo P.C.Y., Tse H., Wu W.L., Chen H., Zheng B. and Yuen K.Y., Wild type and mutant 2009 pandemic influenza A (H1N1) viruses cause more severe disease and higher mortality in pregnant BALB/c mice, PLoS One. 2010, 5: e13757. |
| Du L., Leung H.C., Zhang X., Zhou J., Chen M., He W., Zhang H., Chan C.S., Poon K.M., Zhao G., Sun S., Cai L., Zhou Y., Zheng B. and Jiang S., A recombinant vaccine of H5N1 HA1 fused with foldon and human IgG Fc induced complete cross-clade protection against divergent H5N1 viruses., PloS One. 2011, 6(1):: e16555. |
| Liu S., Li R., Zhang R., Chan C.S., Xi B., Zhu Z., Yang J., Poon K.M., Zhou J., Chen M., Munch J., Kirchhoff F., Pleschka S., Haarmann T., Dietrich U., Pan C., Du L., Jiang S. and Zheng B., CL-385319 inhibits H5N1 avian influenza A virus infection by blocking viral entry. , Eur J Pharmacol . 2011, 660:: 460-467. |
| Zheng B., Chan K.H., Zhang J., Zhou J., Chan C.S., Poon K.M., Zhang K., Leung H.C., Jin D., Woo P.C.Y., Chan J.F.W., To K.K.W., Chen H. and Yuen K.Y., D225G mutation in haemagglutinin of pandemic Influenza H1N1 (2009) virus enhances virulence in mice, Experimental Biology and Medicine. 2010, 235: 981-8. |
| Researcher : Poon LLM |
| Project Title: | Reverse genetic for a coronavirus responsible for severe acute respiratory syndrome |
| Investigator(s): | Poon LLM, Guan Y |
| Department: | Microbiology |
| Source(s) of Funding: | VCO SARS Research Fund |
| Start Date: | 07/2003 |
| Project Title: | International Conference on Options for Control of Influenza V Genetic Characterization of a Novel Coronavirus Responsible for Severe Acute Respiratory Syndrome A Coronavirus Responsible for Severe Acute Respiratory Syndrome |
| Investigator(s): | Poon LLM |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 10/2003 |
| Project Title: | Centre for Research into Circulating Fetal Nucleic Acids |
| Investigator(s): | Poon LLM |
| Department: | Microbiology |
| Source(s) of Funding: | Areas of Excellence Scheme |
| Start Date: | 01/2008 |
| Project Title: | Codon biases of avian and human influenza A viruses |
| Investigator(s): | Poon LLM |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2009 |
| Completion Date: | 12/2010 |
| Project Title: | 15th International Bat Research Conference Detection of emerging viruses in bat guano |
| Investigator(s): | Poon LLM |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 08/2010 |
| Completion Date: | 08/2010 |
| Project Title: | Development of reverse trasncriptase-polymerase chain reaction for the detection of ressortants bewteen pandemic H1N1/2009 and other influenza viruses |
| Investigator(s): | Poon LLM |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 01/2011 |
| List of Research Outputs |
| Chu K.W., Chin W.H., Smith G.J., Chan K.H., Guan Y., Peiris J.S.M. and Poon L.L.M., Detection of novel astroviruses in urban brown rats and previously known astroviruses in humans., J Gen Virol. . 2010, 91: 2457-2462. |
| Chu Y.C., Cheung C.L., Leung C.Y.H., Poon L.L.M., Chen H., Peiris J.S.M. and Guan Y., Continuing Evolution Of H9n2 Influenza Viruses Endemic In Poultry In Southern China, In: JSM Peiris & Y Guan, Options For The Control of Influenza VII. Oxford, UK, Wiley-Blackwell, 2011, 5 Suppl 1: 68-71. |
| Chu Y.C., Cheung C.L., Leung C.Y.H., Poon L.L.M., Chen H., Peiris J.S.M. and Guan Y., Continuing evolution of H9N2 influenza viruses endemic in poultry in southern China, Influenza Other Respi Viruses. 2011, 5: 68-71. |
| Chye M.L., Li H., Ramalingam S., Poon L.L.M. and Peiris J.S.M., Genetically modified plants comprising SARS-CoV viral nucleotide sequences and methods of use thereof for immunization against SARS., Chinese Patent No. z1200480039355.6 issued on Aug 4 . 2010. |
| Dhanasekaran V., Smith G.J., Pybus O.G., Zhu H., Bahl J., Poon L.L.M., Riley S., Bahl J., Ma S.K., Cheung C.L., Perera R.A.P.M., Chen H., Shortridge K.F., Webby R., Guan Y. and Peiris J.S.M., Long-term evolution and transmission dynamics of swine influenza A virus., Nature. 2011, 473: 519-22. |
| Keng C.T., Akerström S., Leung C.S.W., Poon L.L.M., Peiris J.S.M., Mirazimi A. and Tan Y.J., SARS coronavirus 8b reduces viral replication by down-regulating E via an ubiquitin-independent proteasome pathway., Microbes Infect.. 2011, 13: 2. |
| Li O.T.W. and Poon L.L.M., DNA intercalator stimulates influenza transcription and virus replication., Virol J. . 2011, 8: 120. |
| Li O.T.W. and Poon L.L.M., Stalling of RNAPIIo by DNA intercalators activates influenza transcription and virus replication., Options for the Control of Influenza VII, 2010, Hong Kong, 2010 . 2010. |
| Ma S.K., Ho P.L., Cheung C.Y., Tse T.M., Dhanasekaran V., Poon L.L.M., Guan Y. and Peiris J.S.M., Surveillance of influenza viruses in swine in Hong Kong abattoir: methods and feasibility, INFLUENZA AND OTHER RESPIRATORY VIRUSES. 2011, 5: 74-76. |
| Mak W.Y., Wong K.S.C., Li O.T.W., Chan K.H., Cheung C.L., Ma S.K., Webby R.I.C.H.A.R.D., Guan Y., Peiris J.S.M. and Poon L.L.M., Rapid genotyping of swine influenza viruses., Emerg Infect Dis.. 2011, 17: 691-694. |
| Peiris J.S.M. and Poon L.L.M., Detection of SARS coronavirus., Methods Mol Biol. . 2011, 665: 369-82. |
| Poon L.L.M., Detection Of Emerging Viruses In Bat Guano, 15th International Bat Research Conference, Prague, Czech Republic.. 2010. |
| Poon L.L.M., Flu, a striking example of emerging disease, The 7th BioVision, Lyon, France.. 2011. |
| Poon L.L.M., PLoS One, 2010. |
| Poon L.L.M., The Holy Grail: Universal Vaccines for Influenza?, The 8th International Symposium on Antimicrobial Agents and Resistance, Seoul, South Korea.. 2011. |
| Poon L.L.M., Universal Influenza Vaccine?, 7th Pasteur-asia Virology Course, Hong Kong. 2010. |
| Umbach J.L., Yen H., Poon L.L.M. and Cullen B.R., Influenza A Virus Expresses High Levels of an Unusual Class of Small Viral Leader RNAs in Infected Cells, MBio. American Society for Microbiology, 2010, 1(4): e00204-10. |
| Wong H.M.E., Smith D.K., Rabadan R., Peiris J.S.M. and Poon L.L.M., Codon usage bias and the evolution of influenza A viruses. Codon Usage Biases of Influenza Virus., BMC Evol Biol. . 2010, 10: 253. |
| Yen H., Liang C., Wu C., Forrest H., Ferguson A., Choy K.T., Jones J., Wong D.D.Y., Cheung P.H.P., Hsu C., Li O.T.W., Yuen K.M., Chan W.Y., Poon L.L.M., Chan M.C.W., Nicholls J.M., Krauss S., Wong C.H., Guan Y., Webster R.G., Webby R. and Peiris J.S.M., Hemagglutinin-neuraminidase balance confers respiratory droplet transmissibility of the pandemic H1N1 influenza virus in ferrets, Keystone Symposia (Pathogenesis of Influenza: Virus-Host Interactions), May 23-28, 2011, Hong Kong SAR. 2011. |
| Yen H., Forrest H., Cheung P.P.H., Wong D.D.Y., Li O.T.W., Krauss S., Ferguson A., Crumpton J.C., Jones J., Choy K.T., Ma S.K., Poon L.L.M., Smith G.J., Nicholls J.M., Guan Y., Webster R.G., Webby R. and Peiris J.S.M., Transmissibility of pandemic H1N1 and genetically related swine influenza viruses in ferrets, Influenza Other Respi Viruses. 2011, 5: 85-87. |
| Yen H., Forrest H., Cheung P.P.H., Wong D.D.Y., Li O.T.W., Krauss S., Ferguson A., Crumpton J.C., Jones J., Choy K.T., Ma S.K., Poon L.L.M., Smith G.J., Nicholls J.M., Guan Y., Webster R., Webby R. and Peiris J.S.M., Transmissibility of pandemic H1N1 and genetically related swine influenza viruses in ferrets, Options for the Control of Influenza VII, 2010, Hong Kong. 2010. |
| Researcher : Poon RWS |
| List of Research Outputs |
| Lau S.K.P., Poon R.W.S., Wong B.H.L., Wang M., Huang Y., Xu H., Guo R., Li K.S.M., Guo K., Chan K.H., Zheng B., Woo P.C.Y. and Yuen K.Y., Coexistence of different genotypes in the same bat and serological characterization of Rousettus bat coronavirus HKU9 belonging to a novel Betacoronavirus subgroup. , J Virol. 2010, 84(21):: 11358-94. |
| Researcher : Que TL |
| List of Research Outputs |
| Tang S.F., Chan J.F.W., Chen M., Tsang O.T.Y., Mok M.Y., Lai W.Y.M., Lee R.A., Que T.L., Tse H., Li W.S., To K.K.W., Cheng V.C.C., Chan E., Zheng B. and Yuen K.Y., Disseminated penicilliosis, recurrent bacteremic non-typhoidal salmonellosis and burkholderiosis associated with acquired immunodeficiency due to autoantibody against interferon gamma., Clin Vaccine Immunol. 2010, 17(7):: 1132-1138. |
| Researcher : Seto WH |
| List of Research Outputs |
| Cowling B.J., Riley S., Seto W.H. and Leung G.M., Nosocomial transmission and control of SARS, In: Jon Ayres, Roy M Harrison, Gordon Nichols, Robert Maynard, Environmental Medicine. London, Hodder Arnold, 2010, Chapter 16: 205-212. |
| Zhou Y., Ng M.W., Ma S.K., Ip D.K.M., Kwok H., Ng S., Lau L.L.H., Wu J.T.K., Seto W.H., Leung G.M., Peiris J.S.M. and Cowling B.J., Serologic survey among healthcare worker after first wave of 2009 pandemic H1N1 in Hong Kong (abstract and poster presentation), HKCCM International Conference, 4-6 September 2010, Hong Kong. Hong Kong, Hong Kong College of Community Medicine, 2010, 80. |
| Zhou Y., Ng M.W., Ma S.K., Ip D.K.M., Kwok H., Ng S., Lau L.L.H., Wu J.T.K., Seto W.H., Leung G.M., Peiris J.S.M. and Cowling B.J., Seroprevalence of antibody against 2009 pandemic H1N1 among health care workers in Hong Kong, March-April 2010 (abstract), Options for the Control of Influenza VII Conference, 3-7 September 2010, Hong Kong. Hong Kong, Int’l Society for Influenza & Other Respiratory Virus Dis, 2010, 230. |
| Researcher : Shortridge KF |
| List of Research Outputs |
| Dhanasekaran V., Smith G.J., Pybus O.G., Zhu H., Bahl J., Poon L.L.M., Riley S., Bahl J., Ma S.K., Cheung C.L., Perera R.A.P.M., Chen H., Shortridge K.F., Webby R., Guan Y. and Peiris J.S.M., Long-term evolution and transmission dynamics of swine influenza A virus., Nature. 2011, 473: 519-22. |
| Researcher : Sia SF |
| List of Research Outputs |
| Leung C.Y.H., Nicholls J.M., Sia S.F., Hui P.Y., Cheung P.P.H., Chow C.K., Chan W.Y., Chan M.C.W. and Peiris J.S.M., Toll-like Receptor 3 signaling contributes to enhanced disease severity in H5N1 but not pandemic H1N1 infection in mice, Keystone Symposia on Molecular and Cellular Biology: Pathogenesis of Influenza: virus-host interactions. 2011. |
| Tu W., Zheng J., Liu Y., Sia S.F., Liu M., Qin G., Ng I.H.Y., Xiang Z., Lam K.T., Peiris J.S.M. and Lau Y.L., The aminobisphosphonate pamidronate controls influenza pathogenesis by expanding a gammadelta T cell population in humanized mice, Journal of Experimental Medicine. 2011. |
| Researcher : Smith DK |
| Project Title: | Patterns in proteins with unusual flexibility profiles |
| Investigator(s): | Smith DK |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding for New Staff |
| Start Date: | 08/2002 |
| List of Research Outputs |
| Lam T.Y., Zhu H., Wang J., Smith D.K., Holmes E.C., Webster R.G., Webby R., Peiris J.S.M. and Guan Y., Reassortment Events between European Avian-like and American Triple-Reassortant Swine Influenza Viruses in southern China., National Institute of Allergy and Infectious Diseases 5th Annual CEIRS Network Meeting. 2011. |
| Wong H.M.E., Smith D.K., Rabadan R., Peiris J.S.M. and Poon L.L.M., Codon usage bias and the evolution of influenza A viruses. Codon Usage Biases of Influenza Virus., BMC Evol Biol. . 2010, 10: 253. |
| Zhu H., Duan L., Li L., Lam T.Y., Wang J., Smith D.K., Peiris J.S.M. and Guan Y., Detection of a novel swine influenza reassortant virus with human infectious potential and inter-species transmissibility from pigs to ferrets. , 40th Keystone Symposia on Molecular and Cellular Biology: Pathogenesis of Influenza: Virus-host Interactions. 2011. |
| Zhu H., Smith D.K., Lam T.Y., Li L., Zheng Z., Chen R., Zheng R., Zeng Y., Zhou J., Wang J., Chen H., Webster R.G., Webby R., Peiris J.S.M. and Guan Y., Reassortants of the pandemic H1N1/2009 virus in swine and their potential to infect human., National Institute of Allergy and Infectious Diseases 5th Annual CEIRS Network Meeting. 2011. |
| Researcher : Smith GJ |
| Project Title: | Research into the ecology, evolution and population genetics of influenza A (H5N1) virus |
| Investigator(s): | Smith GJ |
| Department: | Microbiology |
| Source(s) of Funding: | National Institutes of Health, US Department of Health and Human Services - General Award |
| Start Date: | 05/2007 |
| Project Title: | Outstanding Young Researcher Award 2008-2009 |
| Investigator(s): | Smith GJ |
| Department: | Microbiology |
| Source(s) of Funding: | Outstanding Young Researcher Award |
| Start Date: | 12/2009 |
| List of Research Outputs |
| Chu K.W., Chin W.H., Smith G.J., Chan K.H., Guan Y., Peiris J.S.M. and Poon L.L.M., Detection of novel astroviruses in urban brown rats and previously known astroviruses in humans., J Gen Virol. . 2010, 91: 2457-2462. |
| Dhanasekaran V., Smith G.J., Pybus O.G., Zhu H., Bahl J., Poon L.L.M., Riley S., Bahl J., Ma S.K., Cheung C.L., Perera R.A.P.M., Chen H., Shortridge K.F., Webby R., Guan Y. and Peiris J.S.M., Long-term evolution and transmission dynamics of swine influenza A virus., Nature. 2011, 473: 519-22. |
| Huang K., Bahl J., Fan X... .H..., Dhanasekaran V., Cheung C.L., Webby R... .J..., Webster R... .G..., Chen H., Smith G.J., Peiris J.S.M. and Guan Y., Establishment of an H6N2 Influenza Virus Lineage in Domestic Ducks in Southern China., J Virol. 2010, 84: 6978-86. |
| Leung C.Y.H., Cheung P.H.P., Zhang L., Wu Y.O., Chow K.C., Ho C.K., Chow C.K., Ng C.F., Tsang C.L., Dhanasekaran V., Smith G.J., Guan Y. and Peiris J.S.M., Influenza Viruses In Wild Birds In Hong Kong, 2003-2010, In: JSM Peiris & Y Guan, Options For The Control Of Influenza VII. Oxford, UK, Wiley-Blackwell, 2011, 5: 77-78. |
| Leung C.Y.H., Cheung P.P.H., Zhang L., Wu Y.O., Chow K.C., Ho C.K., Chow C.K., Ng C.F., Li C., Tsang C.L., Dhanasekaran V., Smith G.J., Guan Y. and Peiris J.S.M., Influenza viruses in wild birds in Hong Kong, 2003-2010 , Influenza Other Respi Viruses. 2011, 5: 77-78. |
| Yen H., Forrest H., Cheung P.P.H., Wong D.D.Y., Li O.T.W., Krauss S., Ferguson A., Crumpton J.C., Jones J., Choy K.T., Ma S.K., Poon L.L.M., Smith G.J., Nicholls J.M., Guan Y., Webster R.G., Webby R. and Peiris J.S.M., Transmissibility of pandemic H1N1 and genetically related swine influenza viruses in ferrets, Influenza Other Respi Viruses. 2011, 5: 85-87. |
| Yen H., Forrest H., Cheung P.P.H., Wong D.D.Y., Li O.T.W., Krauss S., Ferguson A., Crumpton J.C., Jones J., Choy K.T., Ma S.K., Poon L.L.M., Smith G.J., Nicholls J.M., Guan Y., Webster R., Webby R. and Peiris J.S.M., Transmissibility of pandemic H1N1 and genetically related swine influenza viruses in ferrets, Options for the Control of Influenza VII, 2010, Hong Kong. 2010. |
| Researcher : Song W |
| List of Research Outputs |
| Lin S., Liu N., Yang Z., Song W., Wang P., Chen H., Lucio M., Schmitt-Kopplin P., Chen G. and Cai Z., GC/MS-based metabolomics reveals fatty acid biosynthesis and cholesterol metabolism in cell lines infected with influenza A virus, Talanta. 2010, 83: 262-8. |
| Zhu H., Wang J., Wang P., Song W., Zheng Z., Chen R., Guo K., Zhang T., Duan L., Li L., Yip C.H., Peiris J.S.M., Chen H. and Guan Y., Substitution of E627K in PB2 protein does not change virulence of the 2009 pandemic H1N1 virus in mice., Options for the Control of Influenza VII. 2010. |
| Researcher : Sui H |
| List of Research Outputs |
| Zhao G., Lin Y., Guan J., Du L., Sui H., Chan C.S., Kou Z., Guo Y., Jiang S., Zhou Y. and Zheng B., An M2e-based polypeptide vaccine protects mice from lethal challenge with divergent H5N1 influenza viruses., 4TH Congress of European Microbiologists . Geneva, Switzerland., 2011. |
| Zheng B., Du L., Zhao G., Lin Y., Sui H., Chan C.S., He Y., Jiang S., Zhou Y. and Yuen K.Y., SARS-CoV S Protein Induces Strong Mucosal Immune Responses and Provides Long-term Protection Against SARS-CoV Infection., In: Eighth International Symposium on Frontiers in Life Sciences New Advances and Challenges in Multidisciplinary Research., Yinchuan, China., 2010. |
| Researcher : Tai JWM |
| List of Research Outputs |
| Cheng V.C.C., Tai J.W.M., Chan W.M., Lau E.H.Y., Chan J.F.W., To K.K.W., Li W.S., Ho P.L. and Yuen K.Y., Sequential introduction of single room isolation and hand hygiene campaign in the control of methicillin-resistant Staphylococcus aureus in intensive care unit., BMC infectious diseases. 2010, 10: 263. |
| Researcher : Tam WT |
| List of Research Outputs |
| Woo P.C.Y., Tam W.T., Chong T.K., Cai J.J., Tung T.K., Ngan H.Y., Lau S.K.P. and Yuen K.Y., High diversity of polyketide synthase genes and the melanin biosynthesis gene cluster in Penicillium marneffei, FEBS Journal. 2010, 277: 3750-3758. |
| Researcher : Tang LLS |
| List of Research Outputs |
| Chan M.C.W., Chan W.Y., Yen H., Yu C.L., Yuen K.M., Tang L.L.S., Li C.L., Kang S.R., Hui F.F., Lai W.W.K., Sihoe A.D.L., Guan Y., Nicholls J.M. and Peiris J.S.M., ) Tropism and innate host response of the 2009 pandemic H1N1 influenza virus compared with related swine influenza viruses and reassortants in ex vivo and in vitro cultures of the human respiratory tract and conjunctiva, Options for the Control of Influenza VII, 2010. |
| Chan M.C.W., Chan W.Y., Yen H., Yu C.L., Yuen K.M., Tang L.L.S., Li C.L., Kang S.R., Hui F.F., Lai W.W.K., Sihoe A.D.L., Guan Y., Nicholls J.M. and Peiris J.S.M., Tropism and innate host response of the 2009 pandemic H2N2 influenza virus compared with related swine influenza viruses and reassortants in ex vivo and in vitro cultures of the human respiratory tract and conjunctiva, Influenza and other respiratory viruses. 2011, 5 (S1): 54-55. |
| Chan W.Y., Yuen K.M., Yu C.L., Tang L.L.S., Li C.L., Nicholls J.M. and Chan M.C.W., Replication of avian and seasonal influenza viruses in human bronchus and lung, Influenza and other respiratory viruses. 2011, 5: 425-426. |
| Researcher : Tang SF |
| List of Research Outputs |
| Tang S.F., Chan J.F.W., Chen M., Tsang O.T.Y., Mok M.Y., Lai W.Y.M., Lee R.A., Que T.L., Tse H., Li W.S., To K.K.W., Cheng V.C.C., Chan E., Zheng B. and Yuen K.Y., Disseminated penicilliosis, recurrent bacteremic non-typhoidal salmonellosis and burkholderiosis associated with acquired immunodeficiency due to autoantibody against interferon gamma., Clin Vaccine Immunol. 2010, 17(7):: 1132-1138. |
| Researcher : Teng LL |
| Project Title: | Usefulness of full sequence and 5' end 527-bp 16S ribosomal RNA gene sequencing for identification of medically important aerobic Gram-positive cocci |
| Investigator(s): | Teng LL, Woo PCY, Lau SKP, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2006 |
| List of Research Outputs |
| Curreem S.O.T., Teng L.L., Tse H., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., General metabolism of Laribacter hongkongensis: a genome-wide analysis, Cell & Bioscience. 2011, 1: 16. |
| Lam J.Y.W., Wu A.K.L., Ngai D.C., Teng L.L., Wong E.S.Y., Lau S.K.P., Lee R.A. and Woo P.C.Y., Three cases of severe invasive infections caused by Campylobacter rectus and first report of fatal C rectus infection, Journal of Clinical Microbiology. 2011, 49: 1687-1691. |
| Lau S.K.P., Fan Y.Y., Ho C.C., Wong G.K.M., Tsang K.L., Teng L.L., Chen W., Watt R.M., Curreem S.O.T., Tse H., Yuen K.Y. and Woo P.C.Y., Environmental adaptability and stress tolerance of Laribacter hongkongensis: a genome wide analysis, Cell & Bioscience. 2011, 1: 22. |
| Lau S.K.P., Wong G.K.M., Tsang K.L., Teng L.L., Fan Y.Y., Tse H., Yuen K.Y. and Woo P.C.Y., Virulence determinants, drug resistance and mobile genetic elements of Laribacter hongkongensis: a genome-wide analysis, Cell & Bioscience. 2011, 1: 17. |
| To K.K.W., Teng L.L., Wong S.S.Y., Ngan H.Y., Yuen K.Y. and Woo P.C.Y., Complication of corticosteroid treatment by acute Plasmodium malariae infection confirmed by small-subunit rRNA sequencing , Journal of Clinical Microbiology . 2010, 48: 4313-4316. |
| Woo P.C.Y., Teng L.L., Yeung M.Y., Tse H., Lau S.K.P. and Yuen K.Y., Automated identification of medically important bacteria by 16S rRNA gene sequencing using a novel comprehensive database, 16SpathDB, Journal of Clinical Microbiology. 2011, 49: 1799-1809. |
| Researcher : To KKW |
| Project Title: | Safety and efficacy of dose sparing intradermal S-OIV H1N1 influenza vaccination with the novel microneedle delivery device |
| Investigator(s): | To KKW, Hung IFN, Ho PL, Chan KH, Chan CK, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 12/2009 |
| Completion Date: | 12/2010 |
| Project Title: | IgG2 deficiency in patients infected with 2009 H1N1 influenza virus |
| Investigator(s): | To KKW, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2010 |
| Completion Date: | 03/2011 |
| List of Research Outputs |
| Chan J.F.W., Hwang G.Y., Lamb S., Chan G.S.W., So J.C.C., Leung S.S., To K.K.W., Li W.S., Cheng V.C.C. and Yuen K.Y., Pneumococcal native aortic valve endocarditis with mycotic abdominal aortic aneurysm, paraspinal and iliopsoas abscesses and pneumonia revealing a multiple myeloma, J Med Microbiol. 2011, 60(Pt 6): 851-5. |
| Chan J.F.W., To K.K.W., Tse H., Lau C.Y., Li W.S., Hung I.F.N., Chan K.H., Cheng V.C.C., Lai T.S.T., Woo P.C.Y., Chan E.Y.T. and Yuen K.Y., The lower serum immunoglobulin G2 level in severe cases than in mild cases of pandemic H1N1 2009 influenza is associated with cytokine dysregulation, Clinical and Vaccine Immunology. 2010, 18: 305-310. |
| Chan K.H., To K.K.W., Hung I.F.N., Zhang J., Chan J.F.W., Cheng V.C.C., Tse H., Che X.Y., Chen H. and Yuen K.Y., Differences in antibody responses of individuals with natural infection and those vaccinated against pandemic H1N1 2009 influenza., Clinical Vaccine Immunology. 2011, 18: 867-73. |
| Chan K.H., Zhang J., To K.K.W., Chan C.S., Poon K.M., Guo K., Ng F., Zhang Q., Leung H.C., Cheung A.N.Y., Lau C.Y., Woo P.C.Y., Tse H., Wu W.L., Chen H., Zheng B. and Yuen K.Y., Wild type and mutant 2009 pandemic influenza A (H1N1) viruses cause more severe disease and higher mortality in pregnant BALB/c mice, PLoS One. 2010, 5: e13757. |
| Cheng V.C.C., Wong L.M., Tai J.W., Chan J.F.W., To K.K.W., Li W.S., Hung I.F.N., Chan K.H., Ho P.L. and Yuen K.Y., Prevention of nosocomial transmission of norovirus by strategic infection control measures, Infection control and hospital epidemiology. 2011, 32(3): 229-37. |
| Cheng V.C.C., Tai J.W.M., Chan W.M., Lau E.H.Y., Chan J.F.W., To K.K.W., Li W.S., Ho P.L. and Yuen K.Y., Sequential introduction of single room isolation and hand hygiene campaign in the control of methicillin-resistant Staphylococcus aureus in intensive care unit., BMC infectious diseases. 2010, 10: 263. |
| Hung I.F.N., To K.K.W., Lee C...K..., Lee K...L..., Chan K..., Yan W...W..., Liu R..., Watt C...L..., Chan W.M., Lai K...Y..., Koo C...K..., Buckley T..., Chow F...L..., Wong K...K..., Chan H...S..., Ching C...K..., Tang B...S...F..., Lau C.Y., Li W.S., Liu S...H..., Chan K.H., Lin C...K... and Yuen K.Y., Convalescent plasma treatment reduced mortality in patients with severe pandemic influenza A (H1N1) 2009 virus infection , Clinical Infectious Diseases. 2011, 52(4): 447-456. |
| Hung I.F.N., To K.K.W., Lee C.K., Lin C.K., Chan J.F.W., Tse H., Cheng V.C.C., Chen H., Ho P.L., Tse C.W., Ng T.K., Que T.L., Chan K.H. and Yuen K.Y., Effect of Clinical and Virological Parameters on the Level of Neutralizing Antibody against Pandemic Influenza A Virus H1N1 2009, Clin Infect Dis.. 2010, 51: 274-9. |
| Hung I.F.N., To K.K.W., Lee C.K., Lin C.K., Chan J.F.W., Tse H., Cheng V.C.C., Chen H., Ho P.L., Tse C.W.S., Ng T.K., Que T.L., Chan K.H. and Yuen K.Y., Effect of clinical and virological parameters on the level of neutralizing antibody against pandemic influenza A virus H1N1 2009., Clinical Infectious Disease. 2010, 51: 274-9. |
| Tang S.F., Chan J.F.W., Chen M., Tsang O.T.Y., Mok M.Y., Lai W.Y.M., Lee R.A., Que T.L., Tse H., Li W.S., To K.K.W., Cheng V.C.C., Chan E., Zheng B. and Yuen K.Y., Disseminated penicilliosis, recurrent bacteremic non-typhoidal salmonellosis and burkholderiosis associated with acquired immunodeficiency due to autoantibody against interferon gamma., Clin Vaccine Immunol. 2010, 17(7):: 1132-1138. |
| To K.K.W., Azithromycin treatment failure in macrolide-resistant Mycoplasma pneumoniae pneumonia., Eur Respir J.. 2010, 36: 969-971. |
| To K.K.W., Capnocytophaga sputigena primary iliopsoas abscess., J Med Microbiol. 2010. |
| To K.K.W., Clostridium difficile isolates with increased sporulation: emergence of PCR ribotype 002 in Hong Kong., Eur J Clin Microbiol Infect Dis. 2011. |
| To K.K.W., Teng L.L., Wong S.S.Y., Ngan H.Y., Yuen K.Y. and Woo P.C.Y., Complication of corticosteroid treatment by acute Plasmodium malariae infection confirmed by small-subunit rRNA sequencing , Journal of Clinical Microbiology . 2010, 48: 4313-4316. |
| To K.K.W., Complication of corticosteroid treatment by acute Plasmodium malariae infection confirmed by small-subunit rRNA sequencing., J Clin Microbiol. 2010. |
| To K.K.W., Wong S.S.Y., Li W.S., Hung I.F.N., Tse H., Woo P.C.Y., Chan K.H. and Yuen K.Y., Concurrent comparison of epidemiology, clinical presentation and outcome between adult patients suffering from the pandemic influenza A (H1N1) 2009 virus and seasonal influenza A virus infection, Postgrad Med J. 2010. |
| To K.K.W., Differences in antibody responses of individuals with natural infection and those vaccinated against pandemic H1N1 2009 influenza., Clin Vaccine Immunol. 2011. |
| To K.K.W., Effect of applying the new Clinical and Laboratory Standards Institute ceftazidime and ceftriaxone susceptibility breakpoints for Escherichia coli in Hong Kong., Int J Antimicrob Agents.. 2011. |
| To K.K.W., Group B Streptococcal infection in pregnancy: A microbiologist’s perspective, Department of Obstetrics and Gynecology, Queen Mary Hospital. 2010. |
| To K.K.W., Hung I.F.N. and Yuen K.Y., Intradermal 2009 Pandemic Influenza A(H1N1) Vaccination as a Strategy for Dose and Adjuvant Sparing , Infectious Diseases Society of America 48th Annual Meeting. 2010. |
| To K.K.W., Cheng V.C.C., Chan J.F.W., Wong A.C., Chau S., Tsang F.H.F., Curreem S.O.T., Lau S.K.P., Yuen K.Y. and Woo P.C.Y., Molecular characterization of a catalase-negative Staphylococcus aureus subsp. aureus from a patient with mitral valve endocarditis and pericarditis revealed novel nonsense mutation in katA gene., Journal of Clinical Microbiology. 2011. |
| To K.K.W., Woo P.C.Y., Yuen K.Y. and Lau S.K.P., Molecular characterization of a catalase-negative Staphylococcus aureus subsp. aureus from a patient with mitral valve endocarditis and pericarditis revealed novel nonsense mutation in katA gene., J Clin Microbiol. . 2011. |
| To K.K.W., Pathophysiology of Pandemic Influenza, Centre for Health Protection. 2011. |
| To K.K.W., Pneumococcal native aortic valve endocarditis with mycotic abdominal aortic aneurysm, paraspinal and iliopsoas abscesses and pneumonia revealing a multiple myeloma., J Med Microbiol. 2011. |
| To K.K.W., Prevention of nosocomial transmission of norovirus by strategic infection control measures , Infect Control Hosp Epidemiol. 2011, 32: 229-237. |
| To K.K.W., Update of pandemic influenza, Federation of Medical Societies of Hong Kong Annual Scientific Meeting. 2011. |
| Zheng B., Chan K.H., Zhang J., Zhou J., Chan C.S., Poon K.M., Zhang K., Leung H.C., Jin D., Woo P.C.Y., Chan J.F.W., To K.K.W., Chen H. and Yuen K.Y., D225G mutation in haemagglutinin of pandemic Influenza H1N1 (2009) virus enhances virulence in mice, Experimental Biology and Medicine. 2010, 235: 981-8. |
| Researcher : To WCS |
| List of Research Outputs |
| Chen J.H.K., Wong K.H., Chen Z., Chan K.C.W., Lam H.Y., To W.C.S., Cheng V.C.C., Yuen K.Y. and Yam W.C., Increased Genetic Diversity of HIV-1 Circulating in Hong Kong, In: Vlsdimir N., PLoS One. 2010, 5: e12198. |
| Researcher : Tsang CL |
| List of Research Outputs |
| Leung C.Y.H., Cheung P.H.P., Zhang L., Wu Y.O., Chow K.C., Ho C.K., Chow C.K., Ng C.F., Tsang C.L., Dhanasekaran V., Smith G.J., Guan Y. and Peiris J.S.M., Influenza Viruses In Wild Birds In Hong Kong, 2003-2010, In: JSM Peiris & Y Guan, Options For The Control Of Influenza VII. Oxford, UK, Wiley-Blackwell, 2011, 5: 77-78. |
| Leung C.Y.H., Cheung P.P.H., Zhang L., Wu Y.O., Chow K.C., Ho C.K., Chow C.K., Ng C.F., Li C., Tsang C.L., Dhanasekaran V., Smith G.J., Guan Y. and Peiris J.S.M., Influenza viruses in wild birds in Hong Kong, 2003-2010 , Influenza Other Respi Viruses. 2011, 5: 77-78. |
| Researcher : Tsang KL |
| List of Research Outputs |
| Lau S.K.P., Fan Y.Y., Ho C.C., Wong G.K.M., Tsang K.L., Teng L.L., Chen W., Watt R.M., Curreem S.O.T., Tse H., Yuen K.Y. and Woo P.C.Y., Environmental adaptability and stress tolerance of Laribacter hongkongensis: a genome wide analysis, Cell & Bioscience. 2011, 1: 22. |
| Lau S.K.P., Wong G.K.M., Tsang K.L., Teng L.L., Fan Y.Y., Tse H., Yuen K.Y. and Woo P.C.Y., Virulence determinants, drug resistance and mobile genetic elements of Laribacter hongkongensis: a genome-wide analysis, Cell & Bioscience. 2011, 1: 17. |
| Woo P.C.Y., Tsang K.L., Wong Y.P., Chen H., Chu J., Lau S.K.P. and Yuen K.Y., Analysis of multilocus sequence typing schemes for 35 different bacteria revealed that gene loci of 10 bacteria could be replaced to improve cost-effectiveness, Diagnostic Microbiology and Infectious Disease. 2011, 70: 316-323. |
| Researcher : Tsang KL |
| List of Research Outputs |
| Lau S.K.P., Fan Y.Y., Ho C.C., Wong G.K.M., Tsang K.L., Teng L.L., Chen W., Watt R.M., Curreem S.O.T., Tse H., Yuen K.Y. and Woo P.C.Y., Environmental adaptability and stress tolerance of Laribacter hongkongensis: a genome wide analysis, Cell & Bioscience. 2011, 1: 22. |
| Lau S.K.P., Wong G.K.M., Tsang K.L., Teng L.L., Fan Y.Y., Tse H., Yuen K.Y. and Woo P.C.Y., Virulence determinants, drug resistance and mobile genetic elements of Laribacter hongkongensis: a genome-wide analysis, Cell & Bioscience. 2011, 1: 17. |
| Woo P.C.Y., Tsang K.L., Wong Y.P., Chen H., Chu J., Lau S.K.P. and Yuen K.Y., Analysis of multilocus sequence typing schemes for 35 different bacteria revealed that gene loci of 10 bacteria could be replaced to improve cost-effectiveness, Diagnostic Microbiology and Infectious Disease. 2011, 70: 316-323. |
| Researcher : Tse H |
| Project Title: | Multilocus sequence typing of Pseudomonas fluorescens isolates |
| Investigator(s): | Tse H, Yuen KY, Wong SSY |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2009 |
| Completion Date: | 01/2011 |
| Project Title: | Purification and characterization of cytotoxins produced by the human pathogen Staphylococcus lugdunensis |
| Investigator(s): | Tse H, Lau SKP, Woo PCY, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2011 |
| List of Research Outputs |
| Chan J.F.W., To K.K.W., Tse H., Lau C.Y., Li W.S., Hung I.F.N., Chan K.H., Cheng V.C.C., Lai T.S.T., Woo P.C.Y., Chan E.Y.T. and Yuen K.Y., The lower serum immunoglobulin G2 level in severe cases than in mild cases of pandemic H1N1 2009 influenza is associated with cytokine dysregulation, Clinical and Vaccine Immunology. 2010, 18: 305-310. |
| Chan K.H., To K.K.W., Hung I.F.N., Zhang J., Chan J.F.W., Cheng V.C.C., Tse H., Che X.Y., Chen H. and Yuen K.Y., Differences in antibody responses of individuals with natural infection and those vaccinated against pandemic H1N1 2009 influenza., Clinical Vaccine Immunology. 2011, 18: 867-73. |
| Chan K.H., Zhang J., To K.K.W., Chan C.S., Poon K.M., Guo K., Ng F., Zhang Q., Leung H.C., Cheung A.N.Y., Lau C.Y., Woo P.C.Y., Tse H., Wu W.L., Chen H., Zheng B. and Yuen K.Y., Wild type and mutant 2009 pandemic influenza A (H1N1) viruses cause more severe disease and higher mortality in pregnant BALB/c mice, PLoS One. 2010, 5: e13757. |
| Curreem S.O.T., Teng L.L., Tse H., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., General metabolism of Laribacter hongkongensis: a genome-wide analysis, Cell & Bioscience. 2011, 1: 16. |
| Hung I.F.N., To K.K.W., Lee C.K., Lin C.K., Chan J.F.W., Tse H., Cheng V.C.C., Chen H., Ho P.L., Tse C.W., Ng T.K., Que T.L., Chan K.H. and Yuen K.Y., Effect of Clinical and Virological Parameters on the Level of Neutralizing Antibody against Pandemic Influenza A Virus H1N1 2009, Clin Infect Dis.. 2010, 51: 274-9. |
| Hung I.F.N., To K.K.W., Lee C.K., Lin C.K., Chan J.F.W., Tse H., Cheng V.C.C., Chen H., Ho P.L., Tse C.W.S., Ng T.K., Que T.L., Chan K.H. and Yuen K.Y., Effect of clinical and virological parameters on the level of neutralizing antibody against pandemic influenza A virus H1N1 2009., Clinical Infectious Disease. 2010, 51: 274-9. |
| Lau S.K.P., Fan Y.Y., Ho C.C., Wong G.K.M., Tsang K.L., Teng L.L., Chen W., Watt R.M., Curreem S.O.T., Tse H., Yuen K.Y. and Woo P.C.Y., Environmental adaptability and stress tolerance of Laribacter hongkongensis: a genome wide analysis, Cell & Bioscience. 2011, 1: 22. |
| Lau S.K.P., Wong G.K.M., Tsang K.L., Teng L.L., Fan Y.Y., Tse H., Yuen K.Y. and Woo P.C.Y., Virulence determinants, drug resistance and mobile genetic elements of Laribacter hongkongensis: a genome-wide analysis, Cell & Bioscience. 2011, 1: 17. |
| Tang S.F., Chan J.F.W., Chen M., Tsang O.T.Y., Mok M.Y., Lai W.Y.M., Lee R.A., Que T.L., Tse H., Li W.S., To K.K.W., Cheng V.C.C., Chan E., Zheng B. and Yuen K.Y., Disseminated penicilliosis, recurrent bacteremic non-typhoidal salmonellosis and burkholderiosis associated with acquired immunodeficiency due to autoantibody against interferon gamma., Clin Vaccine Immunol. 2010, 17(7):: 1132-1138. |
| To K.K.W., Wong S.S.Y., Li W.S., Hung I.F.N., Tse H., Woo P.C.Y., Chan K.H. and Yuen K.Y., Concurrent comparison of epidemiology, clinical presentation and outcome between adult patients suffering from the pandemic influenza A (H1N1) 2009 virus and seasonal influenza A virus infection, Postgrad Med J. 2010. |
| Tse H., Tsoi H.W., Leung A.S.P., Urquhart I.J., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Complete genome sequence of the veterinary pathogen staphylococcus pseudintermedius strain HKU10-03, isolated in a case of canine pyoderma, Journal of Bacteriology. 2011, 193: 1783-1784. |
| Woo P.C.Y., Teng L.L., Yeung M.Y., Tse H., Lau S.K.P. and Yuen K.Y., Automated identification of medically important bacteria by 16S rRNA gene sequencing using a novel comprehensive database, 16SpathDB, Journal of Clinical Microbiology. 2011, 49: 1799-1809. |
| Researcher : Tse TM |
| List of Research Outputs |
| Ma S.K., Ho P.L., Cheung C.Y., Tse T.M., Dhanasekaran V., Poon L.L.M., Guan Y. and Peiris J.S.M., Surveillance of influenza viruses in swine in Hong Kong abattoir: methods and feasibility, INFLUENZA AND OTHER RESPIRATORY VIRUSES. 2011, 5: 74-76. |
| Researcher : Tsoi HW |
| List of Research Outputs |
| Tse H., Tsoi H.W., Leung A.S.P., Urquhart I.J., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Complete genome sequence of the veterinary pathogen staphylococcus pseudintermedius strain HKU10-03, isolated in a case of canine pyoderma, Journal of Bacteriology. 2011, 193: 1783-1784. |
| Researcher : Tung TK |
| List of Research Outputs |
| Woo P.C.Y., Tam W.T., Chong T.K., Cai J.J., Tung T.K., Ngan H.Y., Lau S.K.P. and Yuen K.Y., High diversity of polyketide synthase genes and the melanin biosynthesis gene cluster in Penicillium marneffei, FEBS Journal. 2010, 277: 3750-3758. |
| Researcher : Wang J |
| List of Research Outputs |
| Zhu H., Wang J., Zheng Z., Li L., Duan L., Yip C.H., Peiris J.S.M., Chen H. and Guan Y., Pathogenicity and transmissibility of the pandemic (H1N1) 2009-related influenza viruses in pigs and mice., Options for the Control of Influenza VII. 2010. |
| Researcher : Wang P |
| List of Research Outputs |
| Lin S., Liu N., Yang Z., Song W., Wang P., Chen H., Lucio M., Schmitt-Kopplin P., Chen G. and Cai Z., GC/MS-based metabolomics reveals fatty acid biosynthesis and cholesterol metabolism in cell lines infected with influenza A virus, Talanta. 2010, 83: 262-8. |
| Zhu H., Wang J., Wang P., Song W., Zheng Z., Chen R., Guo K., Zhang T., Duan L., Li L., Yip C.H., Peiris J.S.M., Chen H. and Guan Y., Substitution of E627K in PB2 protein does not change virulence of the 2009 pandemic H1N1 virus in mice., Options for the Control of Influenza VII. 2010. |
| Researcher : Wen X |
| List of Research Outputs |
| Cheng V.C.C., Chan J.F.W., Wen X., Wu W.L., Que T.L., Chen H., Chan K.H. and Yuen K.Y., Infection of immunocompromised patients by avian H9N2 influenza A virus, J Infect.. 2011, 62: 394-9. |
| Researcher : Wong BHL |
| List of Research Outputs |
| Lau S.K.P., Poon R.W.S., Wong B.H.L., Wang M., Huang Y., Xu H., Guo R., Li K.S.M., Guo K., Chan K.H., Zheng B., Woo P.C.Y. and Yuen K.Y., Coexistence of different genotypes in the same bat and serological characterization of Rousettus bat coronavirus HKU9 belonging to a novel Betacoronavirus subgroup. , J Virol. 2010, 84(21):: 11358-94. |
| Researcher : Wong DDY |
| List of Research Outputs |
| Yen H., Liang C., Wu C., Forrest H., Ferguson A., Choy K.T., Jones J., Wong D.D.Y., Cheung P.H.P., Hsu C., Li O.T.W., Yuen K.M., Chan W.Y., Poon L.L.M., Chan M.C.W., Nicholls J.M., Krauss S., Wong C.H., Guan Y., Webster R.G., Webby R. and Peiris J.S.M., Hemagglutinin-neuraminidase balance confers respiratory droplet transmissibility of the pandemic H1N1 influenza virus in ferrets, Keystone Symposia (Pathogenesis of Influenza: Virus-Host Interactions), May 23-28, 2011, Hong Kong SAR. 2011. |
| Yen H., Forrest H., Cheung P.P.H., Wong D.D.Y., Li O.T.W., Krauss S., Ferguson A., Crumpton J.C., Jones J., Choy K.T., Ma S.K., Poon L.L.M., Smith G.J., Nicholls J.M., Guan Y., Webster R.G., Webby R. and Peiris J.S.M., Transmissibility of pandemic H1N1 and genetically related swine influenza viruses in ferrets, Influenza Other Respi Viruses. 2011, 5: 85-87. |
| Yen H., Forrest H., Cheung P.P.H., Wong D.D.Y., Li O.T.W., Krauss S., Ferguson A., Crumpton J.C., Jones J., Choy K.T., Ma S.K., Poon L.L.M., Smith G.J., Nicholls J.M., Guan Y., Webster R., Webby R. and Peiris J.S.M., Transmissibility of pandemic H1N1 and genetically related swine influenza viruses in ferrets, Options for the Control of Influenza VII, 2010, Hong Kong. 2010. |
| Researcher : Wong GKM |
| List of Research Outputs |
| Lau S.K.P., Fan Y.Y., Ho C.C., Wong G.K.M., Tsang K.L., Teng L.L., Chen W., Watt R.M., Curreem S.O.T., Tse H., Yuen K.Y. and Woo P.C.Y., Environmental adaptability and stress tolerance of Laribacter hongkongensis: a genome wide analysis, Cell & Bioscience. 2011, 1: 22. |
| Lau S.K.P., Wong G.K.M., Tsang K.L., Teng L.L., Fan Y.Y., Tse H., Yuen K.Y. and Woo P.C.Y., Virulence determinants, drug resistance and mobile genetic elements of Laribacter hongkongensis: a genome-wide analysis, Cell & Bioscience. 2011, 1: 17. |
| Researcher : Wong HME |
| List of Research Outputs |
| Wong H.M.E., Smith D.K., Rabadan R., Peiris J.S.M. and Poon L.L.M., Codon usage bias and the evolution of influenza A viruses. Codon Usage Biases of Influenza Virus., BMC Evol Biol. . 2010, 10: 253. |
| Researcher : Wong KH |
| List of Research Outputs |
| Chen J.H.K., Wong K.H., Chen Z., Chan K.C.W., Lam H.Y., To W.C.S., Cheng V.C.C., Yuen K.Y. and Yam W.C., Increased Genetic Diversity of HIV-1 Circulating in Hong Kong, In: Vlsdimir N., PLoS One. 2010, 5: e12198. |
| Researcher : Wong KSC |
| List of Research Outputs |
| Mak W.Y., Wong K.S.C., Li O.T.W., Chan K.H., Cheung C.L., Ma S.K., Webby R.I.C.H.A.R.D., Guan Y., Peiris J.S.M. and Poon L.L.M., Rapid genotyping of swine influenza viruses., Emerg Infect Dis.. 2011, 17: 691-694. |
| Researcher : Wong SSY |
| Project Title: | Molecular characterization of streptococcus bovis bacteraemia |
| Investigator(s): | Wong SSY, Yuen KY, Woo PCY |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2003 |
| Project Title: | Characterization of bacterial isolates with ambiguous biochemical profiles recovered from patients with clinically significant bacteremia by 16S rRNA gene sequencing, the state-of-the-art molecular technique for bacterial identification |
| Investigator(s): | Wong SSY, Woo PCY, Lau SKP |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2004 |
| List of Research Outputs |
| To K.K.W., Teng L.L., Wong S.S.Y., Ngan H.Y., Yuen K.Y. and Woo P.C.Y., Complication of corticosteroid treatment by acute Plasmodium malariae infection confirmed by small-subunit rRNA sequencing , Journal of Clinical Microbiology . 2010, 48: 4313-4316. |
| To K.K.W., Wong S.S.Y., Li W.S., Hung I.F.N., Tse H., Woo P.C.Y., Chan K.H. and Yuen K.Y., Concurrent comparison of epidemiology, clinical presentation and outcome between adult patients suffering from the pandemic influenza A (H1N1) 2009 virus and seasonal influenza A virus infection, Postgrad Med J. 2010. |
| Wong S.S.Y., Yip C.Y., Lau S.K.P. and Yuen K.Y., Human enterovirus 71 and hand, foot and mouth disease, Epidemiology and Infection. 2010, 138: 1071-1089. |
| Researcher : Wong YP |
| List of Research Outputs |
| Woo P.C.Y., Tsang K.L., Wong Y.P., Chen H., Chu J., Lau S.K.P. and Yuen K.Y., Analysis of multilocus sequence typing schemes for 35 different bacteria revealed that gene loci of 10 bacteria could be replaced to improve cost-effectiveness, Diagnostic Microbiology and Infectious Disease. 2011, 70: 316-323. |
| Researcher : Woo P.C.Y. |
| Project Title: | Mechanistic characterization of a novel virulence factor, Mp1p, in Penicillium marneffei |
| Investigator(s): | Woo PCY, Chong TK, Lau SKP, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 08/2007 |
| Completion Date: | 07/2010 |
| Project Title: | Resequencing microarray for detection of viruses in patients with conjunctivitis |
| Investigator(s): | Woo PCY, Lau SKP, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2009 |
| Project Title: | Understanding interclass jumping between mammalian and avian coronaviruses |
| Investigator(s): | Woo PCY, Lau SKP, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2010 |
| Project Title: | A novel pan-genomic analysis approach to select targets for multiplex PCR identification and detection of Burkholderia pseudomallei, Burkholderia thailandensis and Burkholderia cepacia complex species: a proof-of-concept study |
| Investigator(s): | Woo PCY, Lau SKP, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2010 |
| List of Research Outputs |
| Researcher : Woo PCY |
| Project Title: | Mechanistic characterization of a novel virulence factor, Mp1p, in Penicillium marneffei |
| Investigator(s): | Woo PCY, Chong TK, Lau SKP, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 08/2007 |
| Completion Date: | 07/2010 |
| Project Title: | Resequencing microarray for detection of viruses in patients with conjunctivitis |
| Investigator(s): | Woo PCY, Lau SKP, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2009 |
| Project Title: | Understanding interclass jumping between mammalian and avian coronaviruses |
| Investigator(s): | Woo PCY, Lau SKP, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2010 |
| Project Title: | A novel pan-genomic analysis approach to select targets for multiplex PCR identification and detection of Burkholderia pseudomallei, Burkholderia thailandensis and Burkholderia cepacia complex species: a proof-of-concept study |
| Investigator(s): | Woo PCY, Lau SKP, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2010 |
| List of Research Outputs |
| Chan J.F.W., To K.K.W., Tse H., Lau C.Y., Li W.S., Hung I.F.N., Chan K.H., Cheng V.C.C., Lai T.S.T., Woo P.C.Y., Chan E.Y.T. and Yuen K.Y., The lower serum immunoglobulin G2 level in severe cases than in mild cases of pandemic H1N1 2009 influenza is associated with cytokine dysregulation, Clinical and Vaccine Immunology. 2010, 18: 305-310. |
| Chan K.H., Zhang J., To K.K.W., Chan C.S., Poon K.M., Guo K., Ng F., Zhang Q., Leung H.C., Cheung A.N.Y., Lau C.Y., Woo P.C.Y., Tse H., Wu W.L., Chen H., Zheng B. and Yuen K.Y., Wild type and mutant 2009 pandemic influenza A (H1N1) viruses cause more severe disease and higher mortality in pregnant BALB/c mice, PLoS One. 2010, 5: e13757. |
| Curreem S.O.T., Teng L.L., Tse H., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., General metabolism of Laribacter hongkongensis: a genome-wide analysis, Cell & Bioscience. 2011, 1: 16. |
| Ho C.C., Lau C.Y., Mertelli P., Chan S.Y., Tse C.W.S., Wu A.K.L., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Novel pan-genomic analysis approach in target selection for multiplex PCR identification and detection of Burkholderia pseudomallei, Burkholderia thailandensis and Burkholderia cepacia complex species: a proof-of-concept study, Journal of Clinical Microbiology. 2011, 49: 814-821. |
| Lam J.Y.W., Wu A.K.L., Ngai D.C., Teng L.L., Wong E.S.Y., Lau S.K.P., Lee R.A. and Woo P.C.Y., Three cases of severe invasive infections caused by Campylobacter rectus and first report of fatal C rectus infection, Journal of Clinical Microbiology. 2011, 49: 1687-1691. |
| Lau S.K.P. and Woo P.C.Y., Catabacter hongkongensis , Molecular detection of human bacterial pathogens. Taylor and Francis Group, 2011, Chapter 32. |
| Lau S.K.P., Woo P.C.Y., Yip C.Y., Li K.S.M., Fu C.T., Huang Y., Chan K.H. and Yuen K.Y., Co-existence of multiple strains of two novel porcine bocaviruses in the same pig, a previously undescribed phenomenon in members of the family Parvoviridae and evidence for inter- and intra-host genetic diversity and recombination, Journal of General Virology. 2011, 92: 2047-2059. |
| Lau S.K.P., Poon R.W.S., Wong B.H.L., Wang M., Huang Y., Xu H., Guo R., Li K.S.M., Guo K., Chan K.H., Zheng B., Woo P.C.Y. and Yuen K.Y., Coexistence of different genotypes in the same bat and serological characterization of Rousettus bat coronavirus HKU9 belonging to a novel Betacoronavirus subgroup. , J Virol. 2010, 84(21):: 11358-94. |
| Lau S.K.P., Fan Y.Y., Ho C.C., Wong G.K.M., Tsang K.L., Teng L.L., Chen W., Watt R.M., Curreem S.O.T., Tse H., Yuen K.Y. and Woo P.C.Y., Environmental adaptability and stress tolerance of Laribacter hongkongensis: a genome wide analysis, Cell & Bioscience. 2011, 1: 22. |
| Lau S.K.P., Wong G.K.M., Tsang K.L., Teng L.L., Fan Y.Y., Tse H., Yuen K.Y. and Woo P.C.Y., Virulence determinants, drug resistance and mobile genetic elements of Laribacter hongkongensis: a genome-wide analysis, Cell & Bioscience. 2011, 1: 17. |
| Liu C.H., Li L., Chen Z., Wang Q., Hu Y.L., Zhu B. and Woo P.C.Y., Characteristics and treatment outcomes of patients with MDR and XDR tuberculosis in a TB referral hospital in Beijing: a 13-year experience, PLoS One. 2011, 6: e19399. |
| To K.K.W., Teng L.L., Wong S.S.Y., Ngan H.Y., Yuen K.Y. and Woo P.C.Y., Complication of corticosteroid treatment by acute Plasmodium malariae infection confirmed by small-subunit rRNA sequencing , Journal of Clinical Microbiology . 2010, 48: 4313-4316. |
| To K.K.W., Wong S.S.Y., Li W.S., Hung I.F.N., Tse H., Woo P.C.Y., Chan K.H. and Yuen K.Y., Concurrent comparison of epidemiology, clinical presentation and outcome between adult patients suffering from the pandemic influenza A (H1N1) 2009 virus and seasonal influenza A virus infection, Postgrad Med J. 2010. |
| To K.K.W., Cheng V.C.C., Chan J.F.W., Wong A.C., Chau S., Tsang F.H.F., Curreem S.O.T., Lau S.K.P., Yuen K.Y. and Woo P.C.Y., Molecular characterization of a catalase-negative Staphylococcus aureus subsp. aureus from a patient with mitral valve endocarditis and pericarditis revealed novel nonsense mutation in katA gene., Journal of Clinical Microbiology. 2011. |
| To K.K.W., Woo P.C.Y., Yuen K.Y. and Lau S.K.P., Molecular characterization of a catalase-negative Staphylococcus aureus subsp. aureus from a patient with mitral valve endocarditis and pericarditis revealed novel nonsense mutation in katA gene., J Clin Microbiol. . 2011. |
| Tse H., Tsoi H.W., Leung A.S.P., Urquhart I.J., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Complete genome sequence of the veterinary pathogen staphylococcus pseudintermedius strain HKU10-03, isolated in a case of canine pyoderma, Journal of Bacteriology. 2011, 193: 1783-1784. |
| Woo P.C.Y., Lin A.W.C. and Lau S.K.P., Acupuncture transmitted infections, Acupuncture. In Tech-Open Access, 2011. |
| Woo P.C.Y., Ngan H.Y., Chui H.K., Lau S.K.P. and Yuen K.Y., Agar block smear preparation: a novel method of slide preparation for preservation of native fungal structures for microscopic examination and long-term storage, Journal of Clinical Microbiology. 2010, 48: 3053-3061. |
| Woo P.C.Y., Tsang K.L., Wong Y.P., Chen H., Chu J., Lau S.K.P. and Yuen K.Y., Analysis of multilocus sequence typing schemes for 35 different bacteria revealed that gene loci of 10 bacteria could be replaced to improve cost-effectiveness, Diagnostic Microbiology and Infectious Disease. 2011, 70: 316-323. |
| Woo P.C.Y., Teng L.L., Yeung M.Y., Tse H., Lau S.K.P. and Yuen K.Y., Automated identification of medically important bacteria by 16S rRNA gene sequencing using a novel comprehensive database, 16SpathDB, Journal of Clinical Microbiology. 2011, 49: 1799-1809. |
| Woo P.C.Y., Complete genome and proteome of Laribacter hongkongensis: mechanisms for environmental adaptations, 2010 International Conference on Genomics (ICGV), Zhenzhen, China. 2010. |
| Woo P.C.Y., Huang Y., Lau S.K.P. and Yuen K.Y., Coronavirus genomics and bioinformatics analysis, Viruses. 2010, 2: 1804-1820. |
| Woo P.C.Y., Editorial Board member, World Journal of Virology, 2011. |
| Woo P.C.Y., Editorial Board member, PLoS One, 2011. |
| Woo P.C.Y., Editorial Board member, World Journal of Clinical Infectious Diseases, 2011. |
| Woo P.C.Y., Editorial Board member, Cell and Bioscience, 2010. |
| Woo P.C.Y., Tam W.T., Chong T.K., Cai J.J., Tung T.K., Ngan H.Y., Lau S.K.P. and Yuen K.Y., High diversity of polyketide synthase genes and the melanin biosynthesis gene cluster in Penicillium marneffei, FEBS Journal. 2010, 277: 3750-3758. |
| Woo P.C.Y. and Lau S.K.P., Laribacter hongkongensis, Molecular detection of human bacterial pathogens. Taylor and Francis Group, 2011, Chapter 64. |
| Woo P.C.Y., More and more coronaviruses after the SARS epidemic, Hong Kong Medical Forum . 2011. |
| Woo P.C.Y., More and more coronaviruses, Australian Society of Microbiology Conference (Sydney, Australia). 2010. |
| Woo P.C.Y., Lau S.K.P., Lee P., Miao J., Fung A.M.Y., Choi K.Y., Ellis-Behnke R.G. and Yuen K.Y., Resequencing microarray for detection of human adenoviruses in patients with community-acquired gastroenteritis: a proof of concept study, Journal of Medical Microbiology. 2010, 59: 1387-1390. |
| Zheng B., Chan K.H., Zhang J., Zhou J., Chan C.S., Poon K.M., Zhang K., Leung H.C., Jin D., Woo P.C.Y., Chan J.F.W., To K.K.W., Chen H. and Yuen K.Y., D225G mutation in haemagglutinin of pandemic Influenza H1N1 (2009) virus enhances virulence in mice, Experimental Biology and Medicine. 2010, 235: 981-8. |
| Researcher : Wu AKL |
| List of Research Outputs |
| Ho C.C., Lau C.Y., Mertelli P., Chan S.Y., Tse C.W.S., Wu A.K.L., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Novel pan-genomic analysis approach in target selection for multiplex PCR identification and detection of Burkholderia pseudomallei, Burkholderia thailandensis and Burkholderia cepacia complex species: a proof-of-concept study, Journal of Clinical Microbiology. 2011, 49: 814-821. |
| Lam J.Y.W., Wu A.K.L., Ngai D.C., Teng L.L., Wong E.S.Y., Lau S.K.P., Lee R.A. and Woo P.C.Y., Three cases of severe invasive infections caused by Campylobacter rectus and first report of fatal C rectus infection, Journal of Clinical Microbiology. 2011, 49: 1687-1691. |
| Researcher : Wu H |
| List of Research Outputs |
| Wu H., Zhang H., Zhang X., Zhang Q. and Zheng B., Identification of Potential Drug Resistant mutations in HIV-1 Infected Patients with Long-term Undetectable Viral Load after Receiving HAART., HIV DART™ 2010: Frontiers in drug development for in antiretroviral therapies.. Los Cabos, Mexico., 2010. |
| Researcher : Wu WL |
| Project Title: | Characterization of conserved antigenic epitopes in hemagglutinin (HA) of the pandemic (H1N1) influenza virus with cross subtypes neutralizing monoclonal antibodies |
| Investigator(s): | Wu WL, Chen H |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2011 |
| List of Research Outputs |
| Chan K.H., Zhang J., To K.K.W., Chan C.S., Poon K.M., Guo K., Ng F., Zhang Q., Leung H.C., Cheung A.N.Y., Lau C.Y., Woo P.C.Y., Tse H., Wu W.L., Chen H., Zheng B. and Yuen K.Y., Wild type and mutant 2009 pandemic influenza A (H1N1) viruses cause more severe disease and higher mortality in pregnant BALB/c mice, PLoS One. 2010, 5: e13757. |
| Cheng V.C.C., Chan J.F.W., Wen X., Wu W.L., Que T.L., Chen H., Chan K.H. and Yuen K.Y., Infection of immunocompromised patients by avian H9N2 influenza A virus, J Infect.. 2011, 62: 394-9. |
| Zheng Q., Xia L., Wu W.L., Zheng Z., Huo Y., Wu J., Liu Y., Yu H., Chen Y., Lau S.Y., Chen H., Luo W. and Xia N., Properties and therapeutic efficacy of broadly reactive chimeric and humanized H5-specific monoclonal antibodies against H5N1 influenza viruses, Antimicrobial Agents and Chemotherapy. 2011, 55: 1349-57. |
| Researcher : Wu YO |
| List of Research Outputs |
| Leung C.Y.H., Cheung P.H.P., Zhang L., Wu Y.O., Chow K.C., Ho C.K., Chow C.K., Ng C.F., Tsang C.L., Dhanasekaran V., Smith G.J., Guan Y. and Peiris J.S.M., Influenza Viruses In Wild Birds In Hong Kong, 2003-2010, In: JSM Peiris & Y Guan, Options For The Control Of Influenza VII. Oxford, UK, Wiley-Blackwell, 2011, 5: 77-78. |
| Leung C.Y.H., Cheung P.P.H., Zhang L., Wu Y.O., Chow K.C., Ho C.K., Chow C.K., Ng C.F., Li C., Tsang C.L., Dhanasekaran V., Smith G.J., Guan Y. and Peiris J.S.M., Influenza viruses in wild birds in Hong Kong, 2003-2010 , Influenza Other Respi Viruses. 2011, 5: 77-78. |
| Researcher : Yam WC |
| List of Research Outputs |
| Cheng V.C.C., Chan J.F.W., Lau E.H.Y., Yam W.C., Ho S.K.Y., Yau M.C.Y., Tse E.Y.F., Wong A.C.Y., Tai J.W.M., Fan S.T., Ho P.L. and Yuen K.Y., Studying the transmission dynamics of meticillin-resistant Staphylococcus aureus in Hong Kong using spa typing, Journal of Hospital Infection. 2011, 79(3): 206-210. |
| Researcher : Yang Z |
| List of Research Outputs |
| Zhang Y., Li J., Yang Z. and Zhang M., Dual specific antibody co-targeting HIV-1 gp120 and gp41 inhibits virus entry by blocking the shedding of gp120, Next Generation Protein Therapeutics Summit . San Francisco, USA, 2011. |
| Researcher : Yau MCY |
| List of Research Outputs |
| Cheng V.C.C., Chan J.F.W., Lau E.H.Y., Yam W.C., Ho S.K.Y., Yau M.C.Y., Tse E.Y.F., Wong A.C.Y., Tai J.W.M., Fan S.T., Ho P.L. and Yuen K.Y., Studying the transmission dynamics of meticillin-resistant Staphylococcus aureus in Hong Kong using spa typing, Journal of Hospital Infection. 2011, 79(3): 206-210. |
| Researcher : Yen H |
| Project Title: | The role of balanced hemagglutinin-neuraminidase activity on the genesis of transmissible NA inhibitor-resistant variants in seasonal and novel pandemic influenza A H1N1 viruses |
| Investigator(s): | Yen H, Peiris JSM |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 01/2010 |
| Project Title: | Role of influenza hemagglutinin glycoprotein in activation of dendritic cells and induction of effective immune response through C-type lectin receptors |
| Investigator(s): | Yen H, Peiris JSM, Tu W |
| Department: | Microbiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2011 |
| List of Research Outputs |
| Chan M.C.W., Chan W.Y., Yen H., Yu C.L., Yuen K.M., Tang L.L.S., Li C.L., Kang S.R., Hui F.F., Lai W.W.K., Sihoe A.D.L., Guan Y., Nicholls J.M. and Peiris J.S.M., ) Tropism and innate host response of the 2009 pandemic H1N1 influenza virus compared with related swine influenza viruses and reassortants in ex vivo and in vitro cultures of the human respiratory tract and conjunctiva, Options for the Control of Influenza VII, 2010. |
| Chan M.C.W., Chan W.Y., Yen H., Lee M.Y., Guan Y., Nicholls J.M. and Peiris J.S.M., Comparing the tropism of the pandemic H1N1/2009 influenza virus with seasonal influenza virus, related swine influenza viruses and reassortants in ex vivo and in vitro cultures of human conjunctiva and respiratory tract., 4th Annual Center of Excellence for Influenza Research and Surveillance Network Meeting, Woodcliff Hotel and Conference Center 199 Woodcliff Drive, Fairport, NY 14450 . 2010. |
| Chan M.C.W., Chan W.Y., Yen H., Yu C.L., Yuen K.M., Tang L.L.S., Li C.L., Kang S.R., Hui F.F., Lai W.W.K., Sihoe A.D.L., Guan Y., Nicholls J.M. and Peiris J.S.M., Tropism and innate host response of the 2009 pandemic H2N2 influenza virus compared with related swine influenza viruses and reassortants in ex vivo and in vitro cultures of the human respiratory tract and conjunctiva, Influenza and other respiratory viruses. 2011, 5 (S1): 54-55. |
| Umbach J.L., Yen H., Poon L.L.M. and Cullen B.R., Influenza A Virus Expresses High Levels of an Unusual Class of Small Viral Leader RNAs in Infected Cells, MBio. American Society for Microbiology, 2010, 1(4): e00204-10. |
| Yen H. and Yen H., Animal models for the study of influenza virus pathogenesis and transmission, 7th HKU-Pasterur Research Center Virology Course, 2010. 2010. |
| Yen H., Liang C., Wu C., Forrest H., Ferguson A., Choy K.T., Jones J., Wong D.D.Y., Cheung P.H.P., Hsu C., Li O.T.W., Yuen K.M., Chan W.Y., Poon L.L.M., Chan M.C.W., Nicholls J.M., Krauss S., Wong C.H., Guan Y., Webster R.G., Webby R. and Peiris J.S.M., Hemagglutinin-neuraminidase balance confers respiratory droplet transmissibility of the pandemic H1N1 influenza virus in ferrets, Keystone Symposia (Pathogenesis of Influenza: Virus-Host Interactions), May 23-28, 2011, Hong Kong SAR. 2011. |
| Yen H., Forrest H., Cheung P.P.H., Wong D.D.Y., Li O.T.W., Krauss S., Ferguson A., Crumpton J.C., Jones J., Choy K.T., Ma S.K., Poon L.L.M., Smith G.J., Nicholls J.M., Guan Y., Webster R.G., Webby R. and Peiris J.S.M., Transmissibility of pandemic H1N1 and genetically related swine influenza viruses in ferrets, Influenza Other Respi Viruses. 2011, 5: 85-87. |
| Yen H., Forrest H., Cheung P.P.H., Wong D.D.Y., Li O.T.W., Krauss S., Ferguson A., Crumpton J.C., Jones J., Choy K.T., Ma S.K., Poon L.L.M., Smith G.J., Nicholls J.M., Guan Y., Webster R., Webby R. and Peiris J.S.M., Transmissibility of pandemic H1N1 and genetically related swine influenza viruses in ferrets, Options for the Control of Influenza VII, 2010, Hong Kong. 2010. |
| Researcher : Yeung MK |
| List of Research Outputs |
| Ho P.L., Lo W.U., Yeung M.K., Lin C., Chow K.H., Ang L., Tong A.H.Y., Bao Y., Lok S. and Lo J.Y., Complete sequencing of pNDM-HK encoding NDM-1 carbapenemase from a multidrug-resistant Escherichia coli strain isolated in Hong Kong. , PLoS One. 2011, 6: e17989. |
| Researcher : Yeung MY |
| List of Research Outputs |
| Woo P.C.Y., Teng L.L., Yeung M.Y., Tse H., Lau S.K.P. and Yuen K.Y., Automated identification of medically important bacteria by 16S rRNA gene sequencing using a novel comprehensive database, 16SpathDB, Journal of Clinical Microbiology. 2011, 49: 1799-1809. |
| Researcher : Yip CH |
| List of Research Outputs |
| Zhu H., Wang J., Zheng Z., Li L., Duan L., Yip C.H., Peiris J.S.M., Chen H. and Guan Y., Pathogenicity and transmissibility of the pandemic (H1N1) 2009-related influenza viruses in pigs and mice., Options for the Control of Influenza VII. 2010. |
| Zhu H., Wang J., Zheng Z., Chen R., Zheng R., Li L., Duan L., Zhang T., Yip C.H., Yan Z., Chen H., Peiris J.S.M. and Guan Y., Pathogenicity and transmissibility of the pandemic H1N1 2009-related influenza viruses in mice, ferrets, and pigs., Influenza Other Respi Viruses.. 2011, Suppl 1: 82-84. |
| Zhu H., Wang J., Wang P., Song W., Zheng Z., Chen R., Guo K., Zhang T., Duan L., Li L., Yip C.H., Peiris J.S.M., Chen H. and Guan Y., Substitution of E627K in PB2 protein does not change virulence of the 2009 pandemic H1N1 virus in mice., Options for the Control of Influenza VII. 2010. |
| Researcher : Yip CY |
| Project Title: | Complete genome sequence analysis of enterovirus 71 strains from southern China |
| Investigator(s): | Yip CY, Lau SKP, Yuen KY, Woo PCY |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2009 |
| Completion Date: | 02/2011 |
| List of Research Outputs |
| Lau S.K.P., Woo P.C.Y., Yip C.Y., Li K.S.M., Fu C.T., Huang Y., Chan K.H. and Yuen K.Y., Co-existence of multiple strains of two novel porcine bocaviruses in the same pig, a previously undescribed phenomenon in members of the family Parvoviridae and evidence for inter- and intra-host genetic diversity and recombination, Journal of General Virology. 2011, 92: 2047-2059. |
| Wong S.S.Y., Yip C.Y., Lau S.K.P. and Yuen K.Y., Human enterovirus 71 and hand, foot and mouth disease, Epidemiology and Infection. 2010, 138: 1071-1089. |
| Researcher : Yu CL |
| List of Research Outputs |
| Chan M.C.W., Chan W.Y., Yen H., Yu C.L., Yuen K.M., Tang L.L.S., Li C.L., Kang S.R., Hui F.F., Lai W.W.K., Sihoe A.D.L., Guan Y., Nicholls J.M. and Peiris J.S.M., ) Tropism and innate host response of the 2009 pandemic H1N1 influenza virus compared with related swine influenza viruses and reassortants in ex vivo and in vitro cultures of the human respiratory tract and conjunctiva, Options for the Control of Influenza VII, 2010. |
| Chan M.C.W., Chan W.Y., Yen H., Yu C.L., Yuen K.M., Tang L.L.S., Li C.L., Kang S.R., Hui F.F., Lai W.W.K., Sihoe A.D.L., Guan Y., Nicholls J.M. and Peiris J.S.M., Tropism and innate host response of the 2009 pandemic H2N2 influenza virus compared with related swine influenza viruses and reassortants in ex vivo and in vitro cultures of the human respiratory tract and conjunctiva, Influenza and other respiratory viruses. 2011, 5 (S1): 54-55. |
| Chan W.Y., Kang S.R., Yu C.L. and Chan M.C.W., Effect of vitamin B2 in the treatment of human influenza H5N1 virus infection: studies in vitro and in vivo. , Health Research Symposium 2010. |
| Chan W.Y., Hui F.F., Kang S.R., Yu C.L., Nicholls J.M. and Chan M.C.W., Replication and innate host response of influenza A virus in human lung microvascular endothelial cells: insights into systemic dissemination and pathogenesis , Options for the Control of Influenza VII. 2010. |
| Chan W.Y., Yuen K.M., Yu C.L., Tang L.L.S., Li C.L., Nicholls J.M. and Chan M.C.W., Replication of avian and seasonal influenza viruses in human bronchus and lung, Influenza and other respiratory viruses. 2011, 5: 425-426. |
| Hui F.F., Chan W.Y., Fung K.H.Y., Yu C.L., Tsao G.S.W., Chan M.C.W. and Nicholls J.M., The regional distribution of different types of influenza receptors in cultured human alveolar epithelial cells and correlation with in vitro infection, Influenza and other respiratory viruses. 2011, 5(S1): 436-437. |
| Hui F.F., Chan W.Y., Fung K.H.Y., Yu C.L., Tsao G.S.W., Chan M.C.W. and Nicholls J.M., The regional distribution of different types of influenza receptors in cultured human alveolar epithelial cells and correlation with in vitro infection, Influenza and other respiratory viruses. 2011, 5(S1): 436-437. |
| Hui F.F., Chan W.Y., Fung K.H.Y., Yu C.L., Tsao G.S.W., Chan M.C.W. and Nicholls J.M., The regional distribution of different types of influenza receptors in cultured human alveolar epithelial cells and correlation with in vitro infection, Options for the Control of Influenza VII. 2010. |
| Li C.L., Chan W.Y., Hui F.F., Kang S.R., Yu C.L., Nicholls J.M. and Chan M.C.W., Replication and innate host response of influenza A virus in lung microvascular endothelial cells: new insights into systemic infection and pathogenesis, Influenza and other respiratory viruses. 2011, 5 (S1): 287-288. |
| Yu C.L., Chan W.Y., Wang J., Nicholls J.M., Peiris J.S.M., Mason R.J. and Chan M.C.W., Avian influenza H5N1 and seasonal H1N1 virus infection and innate host responses in human alveolar type II epithelial cells and macrophages, Options for the Control of Influenza VII. 2010. |
| Researcher : Yuan T |
| List of Research Outputs |
| Yuan T., Li J., Zhang Y., Wang Y., Streaker E., Dimitrov D.S. and Zhang M., Putative rhesus macaque germline predecessors of human broadly HIV-neutralizing antibodies: differences from the human counterparts and implications for HIV-1 vaccine development , In: Hiroshi Kiyono, D.D.S., PhD. , Vaccine. 2011, in press. |
| Researcher : Yuen K.Y. |
| Project Title: | Establishment of core facilities for the HKU HIV/AIDS research laboratories |
| Investigator(s): | Yuen KY, Zheng B, Woo PCY, Yam WC, Im SWK |
| Department: | Microbiology |
| Source(s) of Funding: | Council for the AIDS Trust Fund - General Award |
| Start Date: | 11/2001 |
| Project Title: | Bacteraemia caused by Anaerotruncus colihominis and emended description of the species |
| Investigator(s): | Yuen KY, Lau SKP, Woo PCY |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2005 |
| Project Title: | Discovery and characterization of novel microbes with epidemic potential |
| Investigator(s): | Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Croucher Senior Medical Research Fellowships |
| Start Date: | 01/2007 |
| Project Title: | Investigation of invasive Lasiodiplodia theobromae infections in humans |
| Investigator(s): | Yuen KY, Tse H, Woo PCY, Lau SKP |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2007 |
| Project Title: | Internal Award for CAE Membership |
| Investigator(s): | Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Internal Award for Chinese Academy of Engineering Membership |
| Start Date: | 02/2008 |
| Project Title: | Molecular epidemiological investigation of PARV-4-related viruses in HK and southern China |
| Investigator(s): | Yuen KY, Tse H, Lau SKP, Woo PCY |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 10/2008 |
| Project Title: | Infection and Immunology |
| Investigator(s): | Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Funding for Strategic Research Theme |
| Start Date: | 11/2008 |
| List of Research Outputs |
| Hung I...F...N... and Yuen K...Y..., Reply to Lee et al, Clinical Infectious Diseases. 2011, 52(4): 559. |
| Researcher : Yuen KY |
| Project Title: | Establishment of core facilities for the HKU HIV/AIDS research laboratories |
| Investigator(s): | Yuen KY, Zheng B, Woo PCY, Yam WC, Im SWK |
| Department: | Microbiology |
| Source(s) of Funding: | Council for the AIDS Trust Fund - General Award |
| Start Date: | 11/2001 |
| Project Title: | Bacteraemia caused by Anaerotruncus colihominis and emended description of the species |
| Investigator(s): | Yuen KY, Lau SKP, Woo PCY |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2005 |
| Project Title: | Discovery and characterization of novel microbes with epidemic potential |
| Investigator(s): | Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Croucher Senior Medical Research Fellowships |
| Start Date: | 01/2007 |
| Project Title: | Investigation of invasive Lasiodiplodia theobromae infections in humans |
| Investigator(s): | Yuen KY, Tse H, Woo PCY, Lau SKP |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2007 |
| Project Title: | Internal Award for CAE Membership |
| Investigator(s): | Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Internal Award for Chinese Academy of Engineering Membership |
| Start Date: | 02/2008 |
| Project Title: | Molecular epidemiological investigation of PARV-4-related viruses in HK and southern China |
| Investigator(s): | Yuen KY, Tse H, Lau SKP, Woo PCY |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 10/2008 |
| Project Title: | Infection and Immunology |
| Investigator(s): | Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Funding for Strategic Research Theme |
| Start Date: | 11/2008 |
| List of Research Outputs |
| Chan J.F.W., Hwang G.Y., Lamb S., Chan G.S.W., So J.C.C., Leung S.S., To K.K.W., Li W.S., Cheng V.C.C. and Yuen K.Y., Pneumococcal native aortic valve endocarditis with mycotic abdominal aortic aneurysm, paraspinal and iliopsoas abscesses and pneumonia revealing a multiple myeloma, J Med Microbiol. 2011, 60(Pt 6): 851-5. |
| Chan J.F.W., To K.K.W., Tse H., Lau C.Y., Li W.S., Hung I.F.N., Chan K.H., Cheng V.C.C., Lai T.S.T., Woo P.C.Y., Chan E.Y.T. and Yuen K.Y., The lower serum immunoglobulin G2 level in severe cases than in mild cases of pandemic H1N1 2009 influenza is associated with cytokine dysregulation, Clinical and Vaccine Immunology. 2010, 18: 305-310. |
| Chan K.H., To K.K.W., Hung I.F.N., Zhang J., Chan J.F.W., Cheng V.C.C., Tse H., Che X.Y., Chen H. and Yuen K.Y., Differences in antibody responses of individuals with natural infection and those vaccinated against pandemic H1N1 2009 influenza., Clinical Vaccine Immunology. 2011, 18: 867-73. |
| Chan K.H., Zhang J., To K.K.W., Chan C.S., Poon K.M., Guo K., Ng F., Zhang Q., Leung H.C., Cheung A.N.Y., Lau C.Y., Woo P.C.Y., Tse H., Wu W.L., Chen H., Zheng B. and Yuen K.Y., Wild type and mutant 2009 pandemic influenza A (H1N1) viruses cause more severe disease and higher mortality in pregnant BALB/c mice, PLoS One. 2010, 5: e13757. |
| Chen J.H.K., Wong K.H., Chen Z., Chan K.C.W., Lam H.Y., To W.C.S., Cheng V.C.C., Yuen K.Y. and Yam W.C., Increased Genetic Diversity of HIV-1 Circulating in Hong Kong, In: Vlsdimir N., PLoS One. 2010, 5: e12198. |
| Cheng V.C.C., Chan J.F.W., Wen X., Wu W.L., Que T.L., Chen H., Chan K.H. and Yuen K.Y., Infection of immunocompromised patients by avian H9N2 influenza A virus, J Infect.. 2011, 62: 394-9. |
| Cheng V.C.C., Wong L.M., Tai J.W., Chan J.F.W., To K.K.W., Li W.S., Hung I.F.N., Chan K.H., Ho P.L. and Yuen K.Y., Prevention of nosocomial transmission of norovirus by strategic infection control measures, Infection control and hospital epidemiology. 2011, 32(3): 229-37. |
| Cheng V.C.C., Tai J.W.M., Chan W.M., Lau E.H.Y., Chan J.F.W., To K.K.W., Li W.S., Ho P.L. and Yuen K.Y., Sequential introduction of single room isolation and hand hygiene campaign in the control of methicillin-resistant Staphylococcus aureus in intensive care unit., BMC infectious diseases. 2010, 10: 263. |
| Cheng V.C.C., Chan J.F.W., Lau E.H.Y., Yam W.C., Ho S.K.Y., Yau M.C.Y., Tse E.Y.F., Wong A.C.Y., Tai J.W.M., Fan S.T., Ho P.L. and Yuen K.Y., Studying the transmission dynamics of meticillin-resistant Staphylococcus aureus in Hong Kong using spa typing, Journal of Hospital Infection. 2011, 79(3): 206-210. |
| Curreem S.O.T., Teng L.L., Tse H., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., General metabolism of Laribacter hongkongensis: a genome-wide analysis, Cell & Bioscience. 2011, 1: 16. |
| Ho C.C., Lau C.Y., Mertelli P., Chan S.Y., Tse C.W.S., Wu A.K.L., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Novel pan-genomic analysis approach in target selection for multiplex PCR identification and detection of Burkholderia pseudomallei, Burkholderia thailandensis and Burkholderia cepacia complex species: a proof-of-concept study, Journal of Clinical Microbiology. 2011, 49: 814-821. |
| Hung I.F.N., To K.K.W., Lee C...K..., Lee K...L..., Chan K..., Yan W...W..., Liu R..., Watt C...L..., Chan W.M., Lai K...Y..., Koo C...K..., Buckley T..., Chow F...L..., Wong K...K..., Chan H...S..., Ching C...K..., Tang B...S...F..., Lau C.Y., Li W.S., Liu S...H..., Chan K.H., Lin C...K... and Yuen K.Y., Convalescent plasma treatment reduced mortality in patients with severe pandemic influenza A (H1N1) 2009 virus infection , Clinical Infectious Diseases. 2011, 52(4): 447-456. |
| Hung I.F.N., To K.K.W., Lee C.K., Lin C.K., Chan J.F.W., Tse H., Cheng V.C.C., Chen H., Ho P.L., Tse C.W., Ng T.K., Que T.L., Chan K.H. and Yuen K.Y., Effect of Clinical and Virological Parameters on the Level of Neutralizing Antibody against Pandemic Influenza A Virus H1N1 2009, Clin Infect Dis.. 2010, 51: 274-9. |
| Hung I.F.N., To K.K.W., Lee C.K., Lin C.K., Chan J.F.W., Tse H., Cheng V.C.C., Chen H., Ho P.L., Tse C.W.S., Ng T.K., Que T.L., Chan K.H. and Yuen K.Y., Effect of clinical and virological parameters on the level of neutralizing antibody against pandemic influenza A virus H1N1 2009., Clinical Infectious Disease. 2010, 51: 274-9. |
| Hung I.F.N., Leung A.Y.M., Chu D.W.S., Leung Y.P., Cheung T..., Chan C.K., Lam C.L.K., Liu S...H..., Chu C...M..., Ho P.L., Chan S.S.C., Lam T.H., Liang R.H.S. and Yuen K.Y., Prevention of acute myocardial infarction and stroke among elderly persons by dual pneumococcal and influenza vaccination: a prospective cohort study, Clinical Infectious Diseases. 2010, 51(9): 1007-1016. |
| Lau S.K.P., Woo P.C.Y., Yip C.Y., Li K.S.M., Fu C.T., Huang Y., Chan K.H. and Yuen K.Y., Co-existence of multiple strains of two novel porcine bocaviruses in the same pig, a previously undescribed phenomenon in members of the family Parvoviridae and evidence for inter- and intra-host genetic diversity and recombination, Journal of General Virology. 2011, 92: 2047-2059. |
| Lau S.K.P., Poon R.W.S., Wong B.H.L., Wang M., Huang Y., Xu H., Guo R., Li K.S.M., Guo K., Chan K.H., Zheng B., Woo P.C.Y. and Yuen K.Y., Coexistence of different genotypes in the same bat and serological characterization of Rousettus bat coronavirus HKU9 belonging to a novel Betacoronavirus subgroup. , J Virol. 2010, 84(21):: 11358-94. |
| Lau S.K.P., Fan Y.Y., Ho C.C., Wong G.K.M., Tsang K.L., Teng L.L., Chen W., Watt R.M., Curreem S.O.T., Tse H., Yuen K.Y. and Woo P.C.Y., Environmental adaptability and stress tolerance of Laribacter hongkongensis: a genome wide analysis, Cell & Bioscience. 2011, 1: 22. |
| Lau S.K.P., Wong G.K.M., Tsang K.L., Teng L.L., Fan Y.Y., Tse H., Yuen K.Y. and Woo P.C.Y., Virulence determinants, drug resistance and mobile genetic elements of Laribacter hongkongensis: a genome-wide analysis, Cell & Bioscience. 2011, 1: 17. |
| Tang S.F., Chan J.F.W., Chen M., Tsang O.T.Y., Mok M.Y., Lai W.Y.M., Lee R.A., Que T.L., Tse H., Li W.S., To K.K.W., Cheng V.C.C., Chan E., Zheng B. and Yuen K.Y., Disseminated penicilliosis, recurrent bacteremic non-typhoidal salmonellosis and burkholderiosis associated with acquired immunodeficiency due to autoantibody against interferon gamma., Clin Vaccine Immunol. 2010, 17(7):: 1132-1138. |
| To K.K.W., Teng L.L., Wong S.S.Y., Ngan H.Y., Yuen K.Y. and Woo P.C.Y., Complication of corticosteroid treatment by acute Plasmodium malariae infection confirmed by small-subunit rRNA sequencing , Journal of Clinical Microbiology . 2010, 48: 4313-4316. |
| To K.K.W., Wong S.S.Y., Li W.S., Hung I.F.N., Tse H., Woo P.C.Y., Chan K.H. and Yuen K.Y., Concurrent comparison of epidemiology, clinical presentation and outcome between adult patients suffering from the pandemic influenza A (H1N1) 2009 virus and seasonal influenza A virus infection, Postgrad Med J. 2010. |
| To K.K.W., Hung I.F.N. and Yuen K.Y., Intradermal 2009 Pandemic Influenza A(H1N1) Vaccination as a Strategy for Dose and Adjuvant Sparing , Infectious Diseases Society of America 48th Annual Meeting. 2010. |
| To K.K.W., Cheng V.C.C., Chan J.F.W., Wong A.C., Chau S., Tsang F.H.F., Curreem S.O.T., Lau S.K.P., Yuen K.Y. and Woo P.C.Y., Molecular characterization of a catalase-negative Staphylococcus aureus subsp. aureus from a patient with mitral valve endocarditis and pericarditis revealed novel nonsense mutation in katA gene., Journal of Clinical Microbiology. 2011. |
| To K.K.W., Woo P.C.Y., Yuen K.Y. and Lau S.K.P., Molecular characterization of a catalase-negative Staphylococcus aureus subsp. aureus from a patient with mitral valve endocarditis and pericarditis revealed novel nonsense mutation in katA gene., J Clin Microbiol. . 2011. |
| Tse H., Tsoi H.W., Leung A.S.P., Urquhart I.J., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Complete genome sequence of the veterinary pathogen staphylococcus pseudintermedius strain HKU10-03, isolated in a case of canine pyoderma, Journal of Bacteriology. 2011, 193: 1783-1784. |
| Tu W., Mao H., Zheng J., Liu Y., Chiu S.S.S., Qin G., Chan P.L., Lam K.T., Guan J., Zhang L., Guan Y., Yuen K.Y., Peiris J.S.M. and Lau Y.L., Cytotoxic T Lymphocytes Established by Seasonal Human Influenza Cross-react against 2009 Pandemic H1N1 Influenza Virus., Journal of Virology. 2010, 84: 6527-35. |
| Tu W., Mao H., Zheng J., Liu Y., Chiu S.S.S., Qin G., Chan P.L., Lam K.T., Guan J., Zhang L., Guan Y., Yuen K.Y., Peiris J.S.M. and Lau Y.L., Cytotoxic T lymphocytes established by seasonal human influenza cross-react against 2009 pandemic H1N1 influenza virus, J Virol. 2010, 84(13): 6527-35. |
| Wong S.S.Y., Yip C.Y., Lau S.K.P. and Yuen K.Y., Human enterovirus 71 and hand, foot and mouth disease, Epidemiology and Infection. 2010, 138: 1071-1089. |
| Woo P.C.Y., Ngan H.Y., Chui H.K., Lau S.K.P. and Yuen K.Y., Agar block smear preparation: a novel method of slide preparation for preservation of native fungal structures for microscopic examination and long-term storage, Journal of Clinical Microbiology. 2010, 48: 3053-3061. |
| Woo P.C.Y., Tsang K.L., Wong Y.P., Chen H., Chu J., Lau S.K.P. and Yuen K.Y., Analysis of multilocus sequence typing schemes for 35 different bacteria revealed that gene loci of 10 bacteria could be replaced to improve cost-effectiveness, Diagnostic Microbiology and Infectious Disease. 2011, 70: 316-323. |
| Woo P.C.Y., Teng L.L., Yeung M.Y., Tse H., Lau S.K.P. and Yuen K.Y., Automated identification of medically important bacteria by 16S rRNA gene sequencing using a novel comprehensive database, 16SpathDB, Journal of Clinical Microbiology. 2011, 49: 1799-1809. |
| Woo P.C.Y., Huang Y., Lau S.K.P. and Yuen K.Y., Coronavirus genomics and bioinformatics analysis, Viruses. 2010, 2: 1804-1820. |
| Woo P.C.Y., Tam W.T., Chong T.K., Cai J.J., Tung T.K., Ngan H.Y., Lau S.K.P. and Yuen K.Y., High diversity of polyketide synthase genes and the melanin biosynthesis gene cluster in Penicillium marneffei, FEBS Journal. 2010, 277: 3750-3758. |
| Woo P.C.Y., Lau S.K.P., Lee P., Miao J., Fung A.M.Y., Choi K.Y., Ellis-Behnke R.G. and Yuen K.Y., Resequencing microarray for detection of human adenoviruses in patients with community-acquired gastroenteritis: a proof of concept study, Journal of Medical Microbiology. 2010, 59: 1387-1390. |
| Wu J.T.K., Lee C.K., Cowling B.J. and Yuen K.Y., Logistical feasibility and potential benefits of a population-wide passive immunotherapy program during an influenza pandemic (Options for the Control of Influenza VII, 3-7 September 2010, Hong Kong), Influenza and Other Respiratory Viruses. 2011, 5(Suppl 1): 226-229. |
| Yu B., Yang M., Wong H.Y.B., Watt R.M., Song E., Zheng B., Yuen K.Y. and Huang J., A method to generate recombinant Salmonella typhi Ty21a strains expressing multiple heterologous genes using an improved recombineering strategy., Applied Microbiology and Biotechnology. 2011, 91: 177-188. |
| Zheng B., Chan K.H., Zhang J., Zhou J., Chan C.S., Poon K.M., Zhang K., Leung H.C., Jin D., Woo P.C.Y., Chan J.F.W., To K.K.W., Chen H. and Yuen K.Y., D225G mutation in haemagglutinin of pandemic Influenza H1N1 (2009) virus enhances virulence in mice, Experimental Biology and Medicine. 2010, 235: 981-8. |
| Zheng B., Du L., Zhao G., Lin Y., Sui H., Chan C.S., He Y., Jiang S., Zhou Y. and Yuen K.Y., SARS-CoV S Protein Induces Strong Mucosal Immune Responses and Provides Long-term Protection Against SARS-CoV Infection., In: Eighth International Symposium on Frontiers in Life Sciences New Advances and Challenges in Multidisciplinary Research., Yinchuan, China., 2010. |
| Researcher : Zhang H |
| Project Title: | A pilot study for the role of TH17 in chronic hepatitis B patients |
| Investigator(s): | Zhang H, Zheng B |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 10/2010 |
| Project Title: | the 1st european conference of microbiology and immunology Low Th17 expression association with Chronic Hepatitis B viral infection by means of reducing viral specific IFNγ releasing in a HBV infection model of IL-17 KO mice |
| Investigator(s): | Zhang H |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 05/2011 |
| List of Research Outputs |
| Du L., Leung H.C., Zhang X., Zhou J., Chen M., He W., Zhang H., Chan C.S., Poon K.M., Zhao G., Sun S., Cai L., Zhou Y., Zheng B. and Jiang S., A recombinant vaccine of H5N1 HA1 fused with foldon and human IgG Fc induced complete cross-clade protection against divergent H5N1 viruses., PloS One. 2011, 6(1):: e16555. |
| Wang Z., Huang J..., Wong K...L..., Wang P...G..., Zhang H., Tanner J...A..., Spiga O..., Bernini A..., Zheng B... and Niccolai N..., On the mechanisms of bananin activity against severe acute respiratory syndrome coronavirus, FEBS Journal. 2011, 278: 383-389. |
| Wu H., Zhang H., Zhang X., Zhang Q. and Zheng B., Identification of Potential Drug Resistant mutations in HIV-1 Infected Patients with Long-term Undetectable Viral Load after Receiving HAART., HIV DART™ 2010: Frontiers in drug development for in antiretroviral therapies.. Los Cabos, Mexico., 2010. |
| Zhang H., Zheng B., Zhang K., Lin Y., Liao W., Zhang T., Shu D. and Wang S., Low Th17 expression is associated with Chronic Hepatitis B infection by reducing viral specific IFNγ releasing in a HBV transfection model of IL-17 KO mice , In: Dr. Ildiko Rita Dunay, University of Freiburg, Germany Chair of the Scientific Organizing Committee , 1st European Conference of Microbiology and Immunology. European Journal of Microbiology and Immunology . 2011. |
| Researcher : Zhang H |
| List of Research Outputs |
| Du L., Leung H.C., Zhang X., Zhou J., Chen M., He W., Zhang H., Chan C.S., Poon K.M., Zhao G., Sun S., Cai L., Zhou Y., Zheng B. and Jiang S., A recombinant vaccine of H5N1 HA1 fused with foldon and human IgG Fc induced complete cross-clade protection against divergent H5N1 viruses., PloS One. 2011, 6(1):: e16555. |
| Wang Z., Huang J..., Wong K...L..., Wang P...G..., Zhang H., Tanner J...A..., Spiga O..., Bernini A..., Zheng B... and Niccolai N..., On the mechanisms of bananin activity against severe acute respiratory syndrome coronavirus, FEBS Journal. 2011, 278: 383-389. |
| Wu H., Zhang H., Zhang X., Zhang Q. and Zheng B., Identification of Potential Drug Resistant mutations in HIV-1 Infected Patients with Long-term Undetectable Viral Load after Receiving HAART., HIV DART™ 2010: Frontiers in drug development for in antiretroviral therapies.. Los Cabos, Mexico., 2010. |
| Zhang H., Zheng B., Zhang K., Lin Y., Liao W., Zhang T., Shu D. and Wang S., Low Th17 expression is associated with Chronic Hepatitis B infection by reducing viral specific IFNγ releasing in a HBV transfection model of IL-17 KO mice , In: Dr. Ildiko Rita Dunay, University of Freiburg, Germany Chair of the Scientific Organizing Committee , 1st European Conference of Microbiology and Immunology. European Journal of Microbiology and Immunology . 2011. |
| Researcher : Zhang J |
| List of Research Outputs |
| Chan K.H., To K.K.W., Hung I.F.N., Zhang J., Chan J.F.W., Cheng V.C.C., Tse H., Che X.Y., Chen H. and Yuen K.Y., Differences in antibody responses of individuals with natural infection and those vaccinated against pandemic H1N1 2009 influenza., Clinical Vaccine Immunology. 2011, 18: 867-73. |
| Chan K.H., Zhang J., To K.K.W., Chan C.S., Poon K.M., Guo K., Ng F., Zhang Q., Leung H.C., Cheung A.N.Y., Lau C.Y., Woo P.C.Y., Tse H., Wu W.L., Chen H., Zheng B. and Yuen K.Y., Wild type and mutant 2009 pandemic influenza A (H1N1) viruses cause more severe disease and higher mortality in pregnant BALB/c mice, PLoS One. 2010, 5: e13757. |
| Zheng B., Chan K.H., Zhang J., Zhou J., Chan C.S., Poon K.M., Zhang K., Leung H.C., Jin D., Woo P.C.Y., Chan J.F.W., To K.K.W., Chen H. and Yuen K.Y., D225G mutation in haemagglutinin of pandemic Influenza H1N1 (2009) virus enhances virulence in mice, Experimental Biology and Medicine. 2010, 235: 981-8. |
| Researcher : Zhang K |
| List of Research Outputs |
| Zhang H., Zheng B., Zhang K., Lin Y., Liao W., Zhang T., Shu D. and Wang S., Low Th17 expression is associated with Chronic Hepatitis B infection by reducing viral specific IFNγ releasing in a HBV transfection model of IL-17 KO mice , In: Dr. Ildiko Rita Dunay, University of Freiburg, Germany Chair of the Scientific Organizing Committee , 1st European Conference of Microbiology and Immunology. European Journal of Microbiology and Immunology . 2011. |
| Zhang K., Yu B., Lou Y.S. and Zheng B., A Pilot Study of Oral Vaccine Development against H5N1 Avian Flu Using Salmonella asdA Mutant as Delivery System., 1st European Conference of Microbiology and Immunology.. Budapest, Hungary., 2011. |
| Zheng B., Chan K.H., Zhang J., Zhou J., Chan C.S., Poon K.M., Zhang K., Leung H.C., Jin D., Woo P.C.Y., Chan J.F.W., To K.K.W., Chen H. and Yuen K.Y., D225G mutation in haemagglutinin of pandemic Influenza H1N1 (2009) virus enhances virulence in mice, Experimental Biology and Medicine. 2010, 235: 981-8. |
| Researcher : Zhang K |
| List of Research Outputs |
| Zhang H., Zheng B., Zhang K., Lin Y., Liao W., Zhang T., Shu D. and Wang S., Low Th17 expression is associated with Chronic Hepatitis B infection by reducing viral specific IFNγ releasing in a HBV transfection model of IL-17 KO mice , In: Dr. Ildiko Rita Dunay, University of Freiburg, Germany Chair of the Scientific Organizing Committee , 1st European Conference of Microbiology and Immunology. European Journal of Microbiology and Immunology . 2011. |
| Zhang K., Yu B., Lou Y.S. and Zheng B., A Pilot Study of Oral Vaccine Development against H5N1 Avian Flu Using Salmonella asdA Mutant as Delivery System., 1st European Conference of Microbiology and Immunology.. Budapest, Hungary., 2011. |
| Zheng B., Chan K.H., Zhang J., Zhou J., Chan C.S., Poon K.M., Zhang K., Leung H.C., Jin D., Woo P.C.Y., Chan J.F.W., To K.K.W., Chen H. and Yuen K.Y., D225G mutation in haemagglutinin of pandemic Influenza H1N1 (2009) virus enhances virulence in mice, Experimental Biology and Medicine. 2010, 235: 981-8. |
| Researcher : Zhang L |
| List of Research Outputs |
| Leung C.Y.H., Cheung P.H.P., Zhang L., Wu Y.O., Chow K.C., Ho C.K., Chow C.K., Ng C.F., Tsang C.L., Dhanasekaran V., Smith G.J., Guan Y. and Peiris J.S.M., Influenza Viruses In Wild Birds In Hong Kong, 2003-2010, In: JSM Peiris & Y Guan, Options For The Control Of Influenza VII. Oxford, UK, Wiley-Blackwell, 2011, 5: 77-78. |
| Leung C.Y.H., Cheung P.P.H., Zhang L., Wu Y.O., Chow K.C., Ho C.K., Chow C.K., Ng C.F., Li C., Tsang C.L., Dhanasekaran V., Smith G.J., Guan Y. and Peiris J.S.M., Influenza viruses in wild birds in Hong Kong, 2003-2010 , Influenza Other Respi Viruses. 2011, 5: 77-78. |
| Tu W., Mao H., Zheng J., Liu Y., Chiu S.S.S., Qin G., Chan P.L., Lam K.T., Guan J., Zhang L., Guan Y., Yuen K.Y., Peiris J.S.M. and Lau Y.L., Cytotoxic T Lymphocytes Established by Seasonal Human Influenza Cross-react against 2009 Pandemic H1N1 Influenza Virus., Journal of Virology. 2010, 84: 6527-35. |
| Tu W., Mao H., Zheng J., Liu Y., Chiu S.S.S., Qin G., Chan P.L., Lam K.T., Guan J., Zhang L., Guan Y., Yuen K.Y., Peiris J.S.M. and Lau Y.L., Cytotoxic T lymphocytes established by seasonal human influenza cross-react against 2009 pandemic H1N1 influenza virus, J Virol. 2010, 84(13): 6527-35. |
| Researcher : Zhang M |
| Project Title: | Identification of HIV-1 vaccine immunogens by antibody in vitro maturation |
| Investigator(s): | Zhang M |
| Department: | Medical Faculty |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 12/2009 |
| Project Title: | Development of “Two-in-One (TiO)” dual specific antibodies targeting both IGF-IR and Her 2 |
| Investigator(s): | Zhang M |
| Department: | Medical Faculty |
| Source(s) of Funding: | Seed Funding Programme for Applied Research |
| Start Date: | 06/2010 |
| Completion Date: | 06/2011 |
| Project Title: | Identification of HIV-1-specific broadly neutralizing human monoclonal antibodies from the B-cell genomic DNA antibody gene repertoires of HIV-1 infected individuals |
| Investigator(s): | Zhang M |
| Department: | Medical Faculty |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2010 |
| Project Title: | Development of yeast display technology for antibody engineering |
| Investigator(s): | Zhang M |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2011 |
| Project Title: | Next Generation Protein Therapeutics Summit Duel specific antibody co-targeting HIV-1 gp120 and gp41 inhibited virus entry by blocking the shedding of gp120 |
| Investigator(s): | Zhang M |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 06/2011 |
| Completion Date: | 06/2011 |
| List of Research Outputs |
| Gift S.K., Zentner I.J., Schon A., McFadden K., Umashankara M., Rajagopal S., Contarino M., Duffy C., Courter J.R., Zhang M., Gershoni J.M., Cocklin S., Dimitrov D.S., Smith A.B., Freire E. and Chaiken I.M., Conformational and structural features of HIV-1 gp120 underlying the dual receptor antagonism by cross-reactive neutralizing antibody m18, Biochemistry. 2011, 50(14): 2756-68. |
| Gift S.K., McFadden K., Zentner I.J., Rajagopal S., Zhang M., Dimitrov D.S. and Chaiken I.M., Monoclonal antibody m18 paratope leading to dual receptor antagonism of HIV-1 gp120, Biochemistry. 2011, 50(14): 2769-79. |
| Yuan T., Li J., Zhang Y., Wang Y., Streaker E., Dimitrov D.S. and Zhang M., Putative rhesus macaque germline predecessors of human broadly HIV-neutralizing antibodies: differences from the human counterparts and implications for HIV-1 vaccine development , In: Hiroshi Kiyono, D.D.S., PhD. , Vaccine. 2011, in press. |
| Zhang M., Feng Y., Wang Y. and Dimitrov D.S., Characterization Of A Chimeric Monoclonal Antibody Against The Insulin-like Growth Factor-i Receptor, In: Janice M. Reichert, Ph.D., MAbs. • 1002 West Ave., Austin, TX 78701, Landes Bioscience, 2010, 1: 475-480. |
| Zhang M., Early Career Investigator Award , "AIDS Vaccine 2011" International Conference. 2011. |
| Zhang Y., Li J., Yang Z. and Zhang M., Dual specific antibody co-targeting HIV-1 gp120 and gp41 inhibits virus entry by blocking the shedding of gp120, Next Generation Protein Therapeutics Summit . San Francisco, USA, 2011. |
| Researcher : Zhang N |
| List of Research Outputs |
| Zhang N., Lin Y., Chen M., Zhang Q., Cao T. and Zheng B., Swine-Origin Influenza Virus Like Particle Vaccine Conferred Complete Protection Against Lethal Viral Challenge in Balb/C Mice., 1st European Conference of Microbiology and Immunology.. Budapest, Hungary., 2011. |
| Researcher : Zhang Q |
| Project Title: | Construction and Characterization of a Full-Length Infectious Molecular Clone from the HIV Type 1 CRF08_BC Isolated in China |
| Investigator(s): | Zhang Q, Zheng B |
| Department: | Microbiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2009 |
| Completion Date: | 10/2010 |
| List of Research Outputs |
| Chan K.H., Zhang J., To K.K.W., Chan C.S., Poon K.M., Guo K., Ng F., Zhang Q., Leung H.C., Cheung A.N.Y., Lau C.Y., Woo P.C.Y., Tse H., Wu W.L., Chen H., Zheng B. and Yuen K.Y., Wild type and mutant 2009 pandemic influenza A (H1N1) viruses cause more severe disease and higher mortality in pregnant BALB/c mice, PLoS One. 2010, 5: e13757. |
| Wu H., Zhang H., Zhang X., Zhang Q. and Zheng B., Identification of Potential Drug Resistant mutations in HIV-1 Infected Patients with Long-term Undetectable Viral Load after Receiving HAART., HIV DART™ 2010: Frontiers in drug development for in antiretroviral therapies.. Los Cabos, Mexico., 2010. |
| Zhang N., Lin Y., Chen M., Zhang Q., Cao T. and Zheng B., Swine-Origin Influenza Virus Like Particle Vaccine Conferred Complete Protection Against Lethal Viral Challenge in Balb/C Mice., 1st European Conference of Microbiology and Immunology.. Budapest, Hungary., 2011. |
| Researcher : Zhang X |
| List of Research Outputs |
| Wu H., Zhang H., Zhang X., Zhang Q. and Zheng B., Identification of Potential Drug Resistant mutations in HIV-1 Infected Patients with Long-term Undetectable Viral Load after Receiving HAART., HIV DART™ 2010: Frontiers in drug development for in antiretroviral therapies.. Los Cabos, Mexico., 2010. |
| Researcher : Zhang Y |
| List of Research Outputs |
| Yuan T., Li J., Zhang Y., Wang Y., Streaker E., Dimitrov D.S. and Zhang M., Putative rhesus macaque germline predecessors of human broadly HIV-neutralizing antibodies: differences from the human counterparts and implications for HIV-1 vaccine development , In: Hiroshi Kiyono, D.D.S., PhD. , Vaccine. 2011, in press. |
| Zhang Y., Li J., Yang Z. and Zhang M., Dual specific antibody co-targeting HIV-1 gp120 and gp41 inhibits virus entry by blocking the shedding of gp120, Next Generation Protein Therapeutics Summit . San Francisco, USA, 2011. |
| Researcher : Zhao G |
| List of Research Outputs |
| Du L., Leung H.C., Zhang X., Zhou J., Chen M., He W., Zhang H., Chan C.S., Poon K.M., Zhao G., Sun S., Cai L., Zhou Y., Zheng B. and Jiang S., A recombinant vaccine of H5N1 HA1 fused with foldon and human IgG Fc induced complete cross-clade protection against divergent H5N1 viruses., PloS One. 2011, 6(1):: e16555. |
| Du L., Zhao G., Zhang X., Liu Z., Yu H., Zheng B., Zhou Y. and Jiang S., Development of a safe and convenient neutralization assay for rapid screening of influenza HA-specific neutralizing monoclonal antibodies., Biochem Biophys Res Commun . 2010, 397(3):: 580-585. |
| Zhao G., Sun S., Du L., Xiao W., Ru Z., Guo Y., Yu H., Jiang S., Long Y., Zheng B. and Zhou Y., An H5N1 M2e-based multiple antigenic peptide vaccine confers heterosubtypic protection from lethal infection with pandemic 2009 H1N1 virus., Virol J. 2010, 7(1):: 151. |
| Zhao G., Lin Y., Guan J., Du L., Sui H., Chan C.S., Kou Z., Guo Y., Jiang S., Zhou Y. and Zheng B., An M2e-based polypeptide vaccine protects mice from lethal challenge with divergent H5N1 influenza viruses., 4TH Congress of European Microbiologists . Geneva, Switzerland., 2011. |
| Zhao G., Lin Y., Du L., Guan J., He Y., Sun S., Xiao W., Chen M., Chan C.S., Kou Z., Lustigman S., Jiang S., Zheng B. and Zhou Y., Induction of protection against divergent H5N1 influenza viruses using a recombinant fusion protein linking influenza M2e to Onchocerca volvulus activation associated protein-1 (ASP-1) adjuvant., Vaccine. 2010, 28(44):: 7233-40. |
| Zheng B., Du L., Zhao G., Lin Y., Sui H., Chan C.S., He Y., Jiang S., Zhou Y. and Yuen K.Y., SARS-CoV S Protein Induces Strong Mucosal Immune Responses and Provides Long-term Protection Against SARS-CoV Infection., In: Eighth International Symposium on Frontiers in Life Sciences New Advances and Challenges in Multidisciplinary Research., Yinchuan, China., 2010. |
| Researcher : Zheng B |
| Project Title: | CCR5 expression on antigen-presenting cens in HIV infection |
| Investigator(s): | Zheng B, Lee SS |
| Department: | Microbiology |
| Source(s) of Funding: | Council for the AIDS Trust Fund - General Award |
| Start Date: | 01/2001 |
| Project Title: | The pattern of chemokine receptor polymorphism in healthy and HIV positive Chinese adults |
| Investigator(s): | Zheng B, Lee SS |
| Department: | Microbiology |
| Source(s) of Funding: | Council for the AIDS Trust Fund - General Award |
| Start Date: | 01/2001 |
| Project Title: | A longitudinal study of HIV-1 drug-resistance for improving management of patients on HARRT (MSS 140R) |
| Investigator(s): | Zheng B, Lu L, Chan KW |
| Department: | Microbiology |
| Source(s) of Funding: | Council for the AIDS Trust Fund - General Award |
| Start Date: | 07/2006 |
| Project Title: | Study of vaccine HA-M2 against H5N1 avian influenza virus |
| Investigator(s): | Zheng B |
| Department: | Microbiology |
| Source(s) of Funding: | Matching Fund for Hi-Tech Research and Development Program of China (863 Projects) |
| Start Date: | 08/2007 |
| Project Title: | Study of AAV- and peptide-based vaccine candidates against influenza virus H5N1 infection in animal model |
| Investigator(s): | Zheng B, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 11/2007 |
| Project Title: | Cross-protective efficacy of immunization with different forms of M2 vaccines and their combinations with HA vaccines against highly pathogenic H5N1 influenza A viruses in mice |
| Investigator(s): | Zheng B, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 10/2009 |
| Project Title: | Co-administration of antiviral and anti-inflammatory agents against avian influenza virus H5N1 infection in animal model |
| Investigator(s): | Zheng B, Yuen KY, Jin D |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 01/2010 |
| Project Title: | The 3rd International Conference on Drug Discovery & Therapy Antiviral effect of DNA aptamers binding H5N1 virus nucleoprotein |
| Investigator(s): | Zheng B |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 02/2011 |
| Completion Date: | 02/2011 |
| List of Research Outputs |
| Cao T., Chen M. and Zheng B., Ientification and Evaluation of Protective Ability of a T Cell Epitope Targeting Nucleoprotein of H5N1 influenza virus. , 1st European Conference of Microbiology and Immunology.. Budapest, Hungary., 2011. |
| Chan K.H., Zhang J., To K.K.W., Chan C.S., Poon K.M., Guo K., Ng F., Zhang Q., Leung H.C., Cheung A.N.Y., Lau C.Y., Woo P.C.Y., Tse H., Wu W.L., Chen H., Zheng B. and Yuen K.Y., Wild type and mutant 2009 pandemic influenza A (H1N1) viruses cause more severe disease and higher mortality in pregnant BALB/c mice, PLoS One. 2010, 5: e13757. |
| Chen L., Yuen Y.F., Li Y., Chan H.M., Zheng B., Huang J. and Guan X., Clinical significance of CHD1L in hepatocellular carcinoma and therapeutic potentials of virus-mediated CHD1L depletion., Gut. 2011, 60(4):: 534-43. |
| Du L., Leung H.C., Jiang S. and Zheng B., A Recombinant Vaccine of H5N1 HA1 Fused with Foldon and Human IgG Fc Induced Complete Cross-Clade Protection against Divergent H5N1 Viruses. , 1st European Conference of Microbiology and Immunology.. Budapest, Hungary, 2011. |
| Du L., Leung H.C., Zhang X., Zhou J., Chen M., He W., Zhang H., Chan C.S., Poon K.M., Zhao G., Sun S., Cai L., Zhou Y., Zheng B. and Jiang S., A recombinant vaccine of H5N1 HA1 fused with foldon and human IgG Fc induced complete cross-clade protection against divergent H5N1 viruses., PloS One. 2011, 6(1):: e16555. |
| Du L., Zhao G., Zhang X., Liu Z., Yu H., Zheng B., Zhou Y. and Jiang S., Development of a safe and convenient neutralization assay for rapid screening of influenza HA-specific neutralizing monoclonal antibodies., Biochem Biophys Res Commun . 2010, 397(3):: 580-585. |
| Lau S.K.P., Poon R.W.S., Wong B.H.L., Wang M., Huang Y., Xu H., Guo R., Li K.S.M., Guo K., Chan K.H., Zheng B., Woo P.C.Y. and Yuen K.Y., Coexistence of different genotypes in the same bat and serological characterization of Rousettus bat coronavirus HKU9 belonging to a novel Betacoronavirus subgroup. , J Virol. 2010, 84(21):: 11358-94. |
| Li P., Liu Y., Dia B., Wang M., Shen J., Zhang Y., Chen X., Yuan J., Wu J., Li K., Lu E., Wu Y., Hao A., Chen X., Wang Y., Liu J., Pickerill S. and Zheng B., Epidemiological investigation of an outbreak of pandemic influenza A (H1N1) 2009 in a boarding school: Serological analysis of 1570 cases. , J Clin Virol. 2011, 50(3):: 235-9. |
| Lin Y., Siu K.L., Tanner J.A. and Zheng B., Antiviral effect of DNA aptamers binding H5N1 virus nucleoprotein., 3rd International Conference on Drug Discovery & Therapy. . Dubai, UAE., 2011. |
| Liu S., Li R., Zhang R., Chan C.S., Xi B., Zhu Z., Yang J., Poon K.M., Zhou J., Chen M., Munch J., Kirchhoff F., Pleschka S., Haarmann T., Dietrich U., Pan C., Du L., Jiang S. and Zheng B., CL-385319 inhibits H5N1 avian influenza A virus infection by blocking viral entry. , Eur J Pharmacol . 2011, 660:: 460-467. |
| Ma S.K.Y., Tang K.H., Chan Y.P., Lee K.W., Kwan P.S., Castilho A.G., Ng I.O.L., Man K., Wong N., To K.F., Zheng B., Lai P.B.S., Lo C.M., Chan K.W. and Guan X.Y., miR-130b promotes CD133(+) liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1, Cell Stem Cell. 2010, 7(6): 694-707. |
| Tang S.F., Chan J.F.W., Chen M., Tsang O.T.Y., Mok M.Y., Lai W.Y.M., Lee R.A., Que T.L., Tse H., Li W.S., To K.K.W., Cheng V.C.C., Chan E., Zheng B. and Yuen K.Y., Disseminated penicilliosis, recurrent bacteremic non-typhoidal salmonellosis and burkholderiosis associated with acquired immunodeficiency due to autoantibody against interferon gamma., Clin Vaccine Immunol. 2010, 17(7):: 1132-1138. |
| Wu H., Zhang H., Zhang X., Zhang Q. and Zheng B., Identification of Potential Drug Resistant mutations in HIV-1 Infected Patients with Long-term Undetectable Viral Load after Receiving HAART., HIV DART™ 2010: Frontiers in drug development for in antiretroviral therapies.. Los Cabos, Mexico., 2010. |
| Xu K., Klenk C., Liu B., Keiner B., Cheng J., Zheng B., Li L., Han Q., Wang C., Li T., Chen Z., Shu Y., Liu J., Klenk H.D. and Sun B., SUMO1 modification of the non-structural protein 1 of influenza A virus., J Virol. 2011, 85(2):: 1086-98. |
| Yu B., Yang M., Wong H.Y.B., Watt R.M., Song E., Zheng B., Yuen K.Y. and Huang J., A method to generate recombinant Salmonella typhi Ty21a strains expressing multiple heterologous genes using an improved recombineering strategy., Applied Microbiology and Biotechnology. 2011, 91: 177-188. |
| Zhang H., Zheng B., Zhang K., Lin Y., Liao W., Zhang T., Shu D. and Wang S., Low Th17 expression is associated with Chronic Hepatitis B infection by reducing viral specific IFNγ releasing in a HBV transfection model of IL-17 KO mice , In: Dr. Ildiko Rita Dunay, University of Freiburg, Germany Chair of the Scientific Organizing Committee , 1st European Conference of Microbiology and Immunology. European Journal of Microbiology and Immunology . 2011. |
| Zhang K., Yu B., Lou Y.S. and Zheng B., A Pilot Study of Oral Vaccine Development against H5N1 Avian Flu Using Salmonella asdA Mutant as Delivery System., 1st European Conference of Microbiology and Immunology.. Budapest, Hungary., 2011. |
| Zhang N., Lin Y., Chen M., Zhang Q., Cao T. and Zheng B., Swine-Origin Influenza Virus Like Particle Vaccine Conferred Complete Protection Against Lethal Viral Challenge in Balb/C Mice., 1st European Conference of Microbiology and Immunology.. Budapest, Hungary., 2011. |
| Zhao G., Sun S., Du L., Xiao W., Ru Z., Guo Y., Yu H., Jiang S., Long Y., Zheng B. and Zhou Y., An H5N1 M2e-based multiple antigenic peptide vaccine confers heterosubtypic protection from lethal infection with pandemic 2009 H1N1 virus., Virol J. 2010, 7(1):: 151. |
| Zhao G., Lin Y., Guan J., Du L., Sui H., Chan C.S., Kou Z., Guo Y., Jiang S., Zhou Y. and Zheng B., An M2e-based polypeptide vaccine protects mice from lethal challenge with divergent H5N1 influenza viruses., 4TH Congress of European Microbiologists . Geneva, Switzerland., 2011. |
| Zhao G., Lin Y., Du L., Guan J., He Y., Sun S., Xiao W., Chen M., Chan C.S., Kou Z., Lustigman S., Jiang S., Zheng B. and Zhou Y., Induction of protection against divergent H5N1 influenza viruses using a recombinant fusion protein linking influenza M2e to Onchocerca volvulus activation associated protein-1 (ASP-1) adjuvant., Vaccine. 2010, 28(44):: 7233-40. |
| Zheng B., Chan K.H., Zhang J., Zhou J., Chan C.S., Poon K.M., Zhang K., Leung H.C., Jin D., Woo P.C.Y., Chan J.F.W., To K.K.W., Chen H. and Yuen K.Y., D225G mutation in haemagglutinin of pandemic Influenza H1N1 (2009) virus enhances virulence in mice, Experimental Biology and Medicine. 2010, 235: 981-8. |
| Zheng B., Lin Y., Shum K.T. and Tanner J.A., DNA aptamers binding H5N1 virus nucleoprotein showed antiviral effects., In: Keystone Symposia: Evolving Approaches to Early-Stage Drug Discovery., Snowbird, Utah, USA, 2011. |
| Zheng B., Du L., Zhao G., Lin Y., Sui H., Chan C.S., He Y., Jiang S., Zhou Y. and Yuen K.Y., SARS-CoV S Protein Induces Strong Mucosal Immune Responses and Provides Long-term Protection Against SARS-CoV Infection., In: Eighth International Symposium on Frontiers in Life Sciences New Advances and Challenges in Multidisciplinary Research., Yinchuan, China., 2010. |
| Researcher : Zheng B. |
| Project Title: | CCR5 expression on antigen-presenting cens in HIV infection |
| Investigator(s): | Zheng B, Lee SS |
| Department: | Microbiology |
| Source(s) of Funding: | Council for the AIDS Trust Fund - General Award |
| Start Date: | 01/2001 |
| Project Title: | The pattern of chemokine receptor polymorphism in healthy and HIV positive Chinese adults |
| Investigator(s): | Zheng B, Lee SS |
| Department: | Microbiology |
| Source(s) of Funding: | Council for the AIDS Trust Fund - General Award |
| Start Date: | 01/2001 |
| Project Title: | A longitudinal study of HIV-1 drug-resistance for improving management of patients on HARRT (MSS 140R) |
| Investigator(s): | Zheng B, Lu L, Chan KW |
| Department: | Microbiology |
| Source(s) of Funding: | Council for the AIDS Trust Fund - General Award |
| Start Date: | 07/2006 |
| Project Title: | Study of vaccine HA-M2 against H5N1 avian influenza virus |
| Investigator(s): | Zheng B |
| Department: | Microbiology |
| Source(s) of Funding: | Matching Fund for Hi-Tech Research and Development Program of China (863 Projects) |
| Start Date: | 08/2007 |
| Project Title: | Study of AAV- and peptide-based vaccine candidates against influenza virus H5N1 infection in animal model |
| Investigator(s): | Zheng B, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 11/2007 |
| Project Title: | Cross-protective efficacy of immunization with different forms of M2 vaccines and their combinations with HA vaccines against highly pathogenic H5N1 influenza A viruses in mice |
| Investigator(s): | Zheng B, Yuen KY |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 10/2009 |
| Project Title: | Co-administration of antiviral and anti-inflammatory agents against avian influenza virus H5N1 infection in animal model |
| Investigator(s): | Zheng B, Yuen KY, Jin D |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 01/2010 |
| Project Title: | The 3rd International Conference on Drug Discovery & Therapy Antiviral effect of DNA aptamers binding H5N1 virus nucleoprotein |
| Investigator(s): | Zheng B |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 02/2011 |
| Completion Date: | 02/2011 |
| List of Research Outputs |
| Wang Z., Huang J..., Wong K...L..., Wang P...G..., Zhang H., Tanner J...A..., Spiga O..., Bernini A..., Zheng B... and Niccolai N..., On the mechanisms of bananin activity against severe acute respiratory syndrome coronavirus, FEBS Journal. 2011, 278: 383-389. |
| Researcher : Zhou J |
| Project Title: | A feasibility study on the inhibition of respiratory syncytial virus infection using siRNAs with a unique motif |
| Investigator(s): | Zhou J, Zheng B |
| Department: | Microbiology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2010 |
| Project Title: | A feasibility study on the inhibition of respiratory syncytial virus infection using siRNAs with a unique motif |
| Investigator(s): | Zhou J, Zheng B |
| Department: | Microbiology |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 01/2011 |
| Project Title: | Keystone Symposia on Molecular and Cellular Biology - Pathogenesis of influenza: virus-host interaction Hemagglutinin mutation D225G in Pandemic influenza H1N1 (2009) virus augments virulence in vitro and in vivo |
| Investigator(s): | Zhou J |
| Department: | Microbiology |
| Source(s) of Funding: | URC/CRCG - Conference Grants for Teaching Staff |
| Start Date: | 05/2011 |
| Completion Date: | 05/2011 |
| List of Research Outputs |
| Du L., Leung H.C., Zhang X., Zhou J., Chen M., He W., Zhang H., Chan C.S., Poon K.M., Zhao G., Sun S., Cai L., Zhou Y., Zheng B. and Jiang S., A recombinant vaccine of H5N1 HA1 fused with foldon and human IgG Fc induced complete cross-clade protection against divergent H5N1 viruses., PloS One. 2011, 6(1):: e16555. |
| Liu S., Li R., Zhang R., Chan C.S., Xi B., Zhu Z., Yang J., Poon K.M., Zhou J., Chen M., Munch J., Kirchhoff F., Pleschka S., Haarmann T., Dietrich U., Pan C., Du L., Jiang S. and Zheng B., CL-385319 inhibits H5N1 avian influenza A virus infection by blocking viral entry. , Eur J Pharmacol . 2011, 660:: 460-467. |
| Zheng B., Chan K.H., Zhang J., Zhou J., Chan C.S., Poon K.M., Zhang K., Leung H.C., Jin D., Woo P.C.Y., Chan J.F.W., To K.K.W., Chen H. and Yuen K.Y., D225G mutation in haemagglutinin of pandemic Influenza H1N1 (2009) virus enhances virulence in mice, Experimental Biology and Medicine. 2010, 235: 981-8. |
| Researcher : Zhu H |
| List of Research Outputs |
| Dhanasekaran V., Smith G.J., Pybus O.G., Zhu H., Bahl J., Poon L.L.M., Riley S., Bahl J., Ma S.K., Cheung C.L., Perera R.A.P.M., Chen H., Shortridge K.F., Webby R., Guan Y. and Peiris J.S.M., Long-term evolution and transmission dynamics of swine influenza A virus., Nature. 2011, 473: 519-22. |
| Duan L., Zhu H., Wang J., Huang K., Cheung C.L., Peiris J.S.M., Chen H. and Guan Y., Influenza virus surveillance in migratory ducks and sentinel ducks at Poyang Lake, China., Influenza Other Respi Viruses. . 2011, Suppl 1: 65-68. |
| Duan L., Zhu H., Huang K., Wang J., Cheung C.L., Peiris J.S.M., Chen H. and Guan Y., Influenza virus surveillance in migratory ducks and sentinel ducks at Poyang Lake, China., Options for the Control of Influenza VII. 2010. |
| Huang K., Cheung C.L., Fan X., Zhu H., Wang J., Duan L., Webby R., Webster R., Chen H., Peiris J.S.M. and Guan Y., Interspecies transmission and lineage replacement of H6 subtype influenza viruses in Southern China. , Options for the Control of Influenza VII. 2010. |
| Lam T.Y., Zhu H., Wang J., Smith D.K., Holmes E.C., Webster R.G., Webby R., Peiris J.S.M. and Guan Y., Reassortment Events between European Avian-like and American Triple-Reassortant Swine Influenza Viruses in southern China., National Institute of Allergy and Infectious Diseases 5th Annual CEIRS Network Meeting. 2011. |
| Zhu H., Duan L., Li L., Lam T.Y., Wang J., Smith D.K., Peiris J.S.M. and Guan Y., Detection of a novel swine influenza reassortant virus with human infectious potential and inter-species transmissibility from pigs to ferrets. , 40th Keystone Symposia on Molecular and Cellular Biology: Pathogenesis of Influenza: Virus-host Interactions. 2011. |
| Zhu H., Wang J., Chen H., Webster R., Webby R., Peiris J.S.M. and Guan Y., Influenza surveillance program in swine in Southern China (Dec 2009-Jun 2010), National Institute of Allergy and Infectious Diseases 4th Annual CEIRS Network Meeting. 2010. |
| Zhu H., Wang J., Zheng Z., Li L., Duan L., Yip C.H., Peiris J.S.M., Chen H. and Guan Y., Pathogenicity and transmissibility of the pandemic (H1N1) 2009-related influenza viruses in pigs and mice., Options for the Control of Influenza VII. 2010. |
| Zhu H., Wang J., Zheng Z., Chen R., Zheng R., Li L., Duan L., Zhang T., Yip C.H., Yan Z., Chen H., Peiris J.S.M. and Guan Y., Pathogenicity and transmissibility of the pandemic H1N1 2009-related influenza viruses in mice, ferrets, and pigs., Influenza Other Respi Viruses.. 2011, Suppl 1: 82-84. |
| Zhu H., Smith D.K., Lam T.Y., Li L., Zheng Z., Chen R., Zheng R., Zeng Y., Zhou J., Wang J., Chen H., Webster R.G., Webby R., Peiris J.S.M. and Guan Y., Reassortants of the pandemic H1N1/2009 virus in swine and their potential to infect human., National Institute of Allergy and Infectious Diseases 5th Annual CEIRS Network Meeting. 2011. |
| Zhu H., Reassortants of the pandemic H1N1/2009 virus in swine and their potential to infect human, National Institute of Allergy and Infectious Diseases 5th Annual CEIRS Network Meeting. 2011. |
| Zhu H., Wang J., Wang P., Song W., Zheng Z., Chen R., Guo K., Zhang T., Duan L., Li L., Yip C.H., Peiris J.S.M., Chen H. and Guan Y., Substitution of E627K in PB2 protein does not change virulence of the 2009 pandemic H1N1 virus in mice., Options for the Control of Influenza VII. 2010. |