Dept of Pathology

DEPT OF PATHOLOGY

Researcher : Au LK

List of Research Outputs

Wong C.C.L., Wong C.M., Tung K.K., Au L.K., Lee M.F., Poon R.T.P., Man K. and Ng I.O.L., The microRNA miR-139 suppresses metastasis and progression of hepatocellular carcinoma by down-regulating Rho-kinase 2, Gastroenterology. 2011, 140(1): 322-331.

Wong C.M., Wong C.C.L., Tung K.K., Au L.K., Lee M.F., Man K. and Ng I.O.L., MiR-139 suppresses metastasis and progression of hepatocellular carcinoma through regulation of Rho-Kinase 2 (ROCK2), International Liver Cancer Association Fourth Annual Conference . Montreal, QC, Canada, 2010.

Wong C.M., Wong C.C.L., Ng Y.L., Au L.K., Ko F.C.F. and Ng I.O.L., Transcriptional repressive H3K9 and H3K27 methylations contribute to DNMT1-mediated DNA methylation recovery, American Association for Cancer Research (AACR) 102 st Annual meeting 2011.

Researcher : Au LK

List of Research Outputs

Researcher : Beh SL

Project Title:	The attitudes of doctors toward rape victims
Investigator(s):	Beh SL
Department:	Pathology
Source(s) of Funding:	Other Funding Scheme
Start Date:	06/1993

List of Research Outputs

Beh S.L. and Payne-James J.A.S.O.N., Adult Sexual Assault, In: John Gall , Current Practice In Forensic Medicine. UK, John Wiley, 2011, 95-118.

Beh S.L., Death Investigation System In Hong Kong, 2011 Asia Pacific International Conference On Forensic Pathology And Forensic Science. 2011.

Beh S.L., Homicide Research And Forensic Pathology, Iv Mediterranean Academy Of Forensic Sciences. 2010.

Chan L.C., Beh S.L. and Yip Y.N., Young Chinese medical students adapt well to problem-based learning, Medical Teacher. 2011, 33: 506.

Chen J.Y., Yip L.M., Beh S.L. and Patil N.G., Medical school culture: more positive than you think, AMEE Conference 2011. Vienna, Austria.

Cheung A.N.Y., Lo C.L.R., Ho S.L., Kong P.L., Tipoe G. and Beh S.L., MULTI-MEDIA DIGITAL TUTORIAL FOR MEDICAL EDUCATION, Frontiers in Health and Medical Sciences Education HKU 2010.

Researcher : Castilho AG

List of Research Outputs

Lee K.W., Castilho A.G., Cheung C.H., Tang K.H., Ma S.K.Y. and Ng I.O.L., CD24+ liver tumor initiating cells drive self-renewal and tumor initiation through Stat3- mediated Nanog regulation, AACR 102nd Annual meddting 2011.

Lee K.W., Castilho A.G., Cheung C.H., Tang K.H., Ma S.K.Y. and Ng I.O.L., Lupeol targets liver tumor initiating cells through PTEN modulation, Hepatology. 2011, 53: 160-70.

Ma S.K.Y., Tang K.H., Chan Y.P., Lee K.W., Kwan P.S., Castilho A.G., Ng I.O.L., Man K., Wong N., To K.F., Zheng B., Lai P.B.S., Lo C.M., Chan K.W. and Guan X.Y., miR-130b promotes CD133(+) liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1, Cell Stem Cell. 2010, 7(6): 694-707.

Researcher : Castilho AG

List of Research Outputs

Lee K.W., Castilho A.G., Cheung C.H., Tang K.H., Ma S.K.Y. and Ng I.O.L., Lupeol targets liver tumor initiating cells through PTEN modulation, Hepatology. 2011, 53: 160-70.

Researcher : Chan AOK

List of Research Outputs

Lee H.H.C., Mak C.M., Lam C.W., Yuen L.Y.P., Chan A.O.K., Shek C.C., Siu T.S., Lai C.K., Ching D.C.K., Siu C.W.K., Chen S.P.L., Law C.Y., Tai M.H.L., Tam S. and Chan A.Y.W., Analysis of inborn errors of metabolism: disease spectrum for expanded newborn screening in Hong Kong, Chinese Medical Journal (English Edition). 2011, 124(7): 983-9.

Researcher : Chan AYW

List of Research Outputs

Chen S.P.L., Poon D.W.T., Mak C.M., Kwong Y.L., Chan A.Y.W. and Tam S., Application of pharmacogenetics: UGT1A1*28 and nilotinib-induced unconjugated hyperbilirubinaemia in a patient with chronic myeloid leukaemia, Pathology. 2011, 43(3): 273-4.

Lam C.W., Lau K.C., Mak C.M., Tsang M.W. and Chan A.Y.W., Circulating fluorocytes at the first attack of acute intermittent porphyria: a missing link in the pathogenesis, Clinica Chimica Acta. 2011, 412(1-2): 208-12.

Lau K.C., Lam C.W., Law C.Y., Lai S.T., Tsang T.Y., To W.K., Leung K.F., Mak C.M., Poon D.W.T., Chan P.K. and Chan A.Y.W., Non-invasive screening of HLA-DPA1 and HLA-DPB1 alleles for persistent hepatitis B virus infection: susceptibility for vertical transmission and toward a personalized approach for vaccination and treatment, Clinica Chimica Acta. 2011, 412(11-12): 952-7.

Lee H.H.C., Mak C.M., Lam C.W., Yuen L.Y.P., Chan A.O.K., Shek C.C., Siu T.S., Lai C.K., Ching D.C.K., Siu C.W.K., Chen S.P.L., Law C.Y., Tai M.H.L., Tam S. and Chan A.Y.W., Analysis of inborn errors of metabolism: disease spectrum for expanded newborn screening in Hong Kong, Chinese Medical Journal (English Edition). 2011, 124(7): 983-9.

Lee H.H.C., Lai C.K., Siu T.S., Chan K.Y., Chan A.Y.W., Tam S., Mak C.M. and Lam C.W., Role of Postmortem Genetic Testing Demonstrated in a Case of Glutaric Aciduria Type II, Diagnostic Molecular Pathology . 2010, 19(3): 184-6.

Mak C.M., Sheng B., Lee H.H.C., Lau K.K., Chan W.T., Lam C.W. and Chan A.Y.W., Young-onset parkinsonism in a Hong Kong Chinese man with adult-onset Hallervorden-Spatz syndrome, International Journal of Neuroscience. 2011, 121(4): 224-7.

Siu C.W.K., Ma R.C., Lam C.W., Mak C.M., Yuen L.Y.P., Lo F.M., Chan K.W., Lam S.F., Ling S.C., Tong S.F., So W.Y., Chow C.C., Tang M.H., Tam W.H. and Chan A.Y.W., Molecular basis of von Hippel-Lindau syndrome in Chinese patients, Chinese Medical Journal (English Version). 2011, 124(2): 237-41.

Researcher : Chan EYT

List of Research Outputs

Chan J.F.W., To K.K.W., Tse H., Lau C.Y., Li W.S., Hung I.F.N., Chan K.H., Cheng V.C.C., Lai T.S.T., Woo P.C.Y., Chan E.Y.T. and Yuen K.Y., The lower serum immunoglobulin G2 level in severe cases than in mild cases of pandemic H1N1 2009 influenza is associated with cytokine dysregulation, Clinical and Vaccine Immunology. 2010, 18: 305-310.

Researcher : Chan GSW

List of Research Outputs

Chan J.F.W., Hwang G.Y., Lamb S., Chan G.S.W., So J.C.C., Leung S.S., To K.K.W., Li W.S., Cheng V.C.C. and Yuen K.Y., Pneumococcal native aortic valve endocarditis with mycotic abdominal aortic aneurysm, paraspinal and iliopsoas abscesses and pneumonia revealing a multiple myeloma, J Med Microbiol. 2011, 60(Pt 6): 851-5.

Cheung C.Y., Lam M.F., Lee K.C., Chan G.S.W., Chan K.W., Chau K.F., Li C.S., Chan D.T.M. and Lai K.N., Renal cell carcinoma of native kidney in Chinese renal transplant recipients: a report of 12 cases and a review of the literature, International Urology and Nephrology. 2011, 43(3): 675-80.

Researcher : Chan HY

List of Research Outputs

Jiang L., Siu K.Y., Wong G.W., Tam K.F., Ngan H.Y.S., Wong S.Y., Chan H.Y. and Cheung A.N.Y., Overexpression of proto-oncogene FBI-1 activates membrane type 1-matrix metalloproteinase in association with adverse outcome in ovarian cancers., Molecular cancer. 2010, 9: 318.

Siu K.Y., Wong E.S.Y., Chan H.Y., Kong S.H., Woo N.W., Tam K.F., Ngan H.Y.S., Chan Q.K.Y., Chan D.C., Chan Y.K. and Cheung A.N.Y., Differential expression and phosphorylation of Pak1 and Pak2 in ovarian cancer: effects on prognosis and cell invasion, International Journal of Cancer. 2010.

Siu K.Y., Chan H.Y., Kong S.H., Wong E.S.Y., Wong G.W., Ngan H.Y.S., Tam K.F., Tsao G.S.W. and Cheung A.N.Y., p21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients., Proceedings of the National Academy of Sciences of the United States of America . 2010, 107: 18622-18627.

Siu K.Y., Chan H.Y., Kong S.H., Wong S.Y., Wong G.W., Ngan H.Y.S., Tam K.F., Zhang H., Li Z., Chan Q.K.Y., Tsao G.S.W., Strömblad S. and Cheung A.N.Y., p21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients, PNAS. 2010, 107(43): 18622-18627.

Researcher : Chan J

List of Research Outputs

Chan J., Ko F.C.F., Ng I.O.L. and Yam J.W.P., Integrin-linked kinase overexpression and its oncogenic role in promoting tumorigenicity of hepatocellular carcinoma, PLoS ONE. 2011, 6(2): e16984.

Researcher : Chan KK

List of Research Outputs

Yuen H.F., McCrudden C.M., Chan K.K., Chan Y.P., Wong M.L.Y., Chan Y.K., Khoo U.S., Law S., Srivastava G., Lappin T.R., Chan K.W. and El-Tanani M., The role of pea3 group transcription factors in esophageal squamous cell carcinoma, Am J Pathol. 2011, 179 (2): 992-1003.

Researcher : Chan KW

Project Title:	Identification, Characterization and Therapeutic Targeting of Tumourigenic Liver Cancer Stem Cells
Investigator(s):	Chan KW, Guan X
Department:	Pathology
Source(s) of Funding:	Michael and Betty Kadoorie Cancer Genetics Research Programme (MBKCGRP) II
Start Date:	01/2008

Project Title:	The regulatory role of miR-616 in the androgen-independent growth of prostate cancer
Investigator(s):	Chan KW, Ma SKY
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2008
Completion Date:	08/2010

Project Title:	The roles of Id-1 in prostate cancer to bone metastasis
Investigator(s):	Chan KW
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2009
Completion Date:	04/2011

Project Title:	The role of BARX2 in esophageal squamous cell carcinoma
Investigator(s):	Chan KW
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	03/2011

List of Research Outputs

Chan K.C., Ko J.M.Y., Lung H.L., Sedlacek R., Zhang Z.F., Luo D.Z., Feng Z.B., Chen S., Chen H., Chan K.W., Tsao G.S.W., Chua D.T.T., Zabarovsky E.R., Stanbridge E.J. and Lung M.L., Catalytic activity of matrix metalloproteinase-19 is essential for tumor suppressor and anti-angiogenic activities in nasopharyngeal carcinoma, International Journal of Cancer. 2010.

Chan S.H.K., Ko J.M.Y., Chan K.W., Chan Y.P., Tao Q., Hyytiainen M., Keski-Oja J., Law S.Y.K., Srivastava G., Tang J., Tsao G.S.W., Chen H., Stanbridge E.J. and Lung M.L., The ECM portein LTBP-2 is a suppressor of esophageal squamous cell carcinoma tumor formation but higher tumor expression associates with poor patient outcome, International Journal of Cancer. 2011, 129: 565-573.

Cheung A.K.L., Ko J.M.Y., Lung H.L., Chan K.W., Stanbridge E.J., Zabarovsky E.R., Kwong D.L.W., Chua D.T.T., Tsao G.S.W. and Lung M.L., CRIP2 is a candidate tumor suppressor in nasopharyngeal carcinoma associated with in vivo tumor suppression and angiogenesis inhibition., The 17th Hong Kong International Cancer Congress. Hong Kong SAR, China, 2010.

Cheung A.K.L., Ko J.M.Y., Lung H.L., Chan K.W., Stanbridge E.J., Zabarovsky E., Tokino T., Kashima L., Suzuki T., Kwong D.L.W., Chua D.T.T., Tsao G.S.W. and Lung M.L., Cysteine-rich intestinal protein 2 (CRIP2) acts as a repressor of NF-kB-mediated proangiogenic cytokine transcription to suppress tumorigenesis and angiogenesis, PNAS. 2011, 108(20): 8390-8395.

Cheung C.Y., Lam M.F., Lee K.C., Chan G.S.W., Chan K.W., Chau K.F., Li C.S., Chan D.T.M. and Lai K.N., Renal cell carcinoma of native kidney in Chinese renal transplant recipients: a report of 12 cases and a review of the literature, International Urology and Nephrology. 2011, 43(3): 675-80.

Chua C.W., Chiu Y.T., Yuen H.F., Chan K.W., Wang X., Ling M.T. and Wong Y.C., Differential expression of MSX2 in nodular hyperplasia, high-grade prostatic intraepithelial neoplasia and prostate adenocarcinoma, APMIS. 2010, 118(12): 918-26.

Lo H.Y.P., Lung H.L., Cheung A.K.L., Apte S.S., Chan K.W., Kwong F.M., Ko J.M.Y., Cheng Y., Law S.Y.K., Srivastava G., Zabarovsky E.R., Tsao G.S.W., Tang J.C., Stanbridge E.J. and Lung M.L., Extracellular protease ADAMTS9 suppresses esophageal and nasopharyngeal carcinoma tumor formation by inhibiting angiogenesis, Cancer Res. 2010, 70(13): 5567-76.

Ma S.K.Y., Kwan P.S., Chan Y.P., Fu L., Tang K.H., Tong M., Chan K.W. and Guan X., RNA-Seq identifies protein tyrosine kinase 6 (PTK6) as a candidate tumor-suppressor gene in esophageal squamous cell carcinoma , American Association for Cancer Research - Annual Meeting 2011.

Ma S.K.Y., Tang K.H., Chan Y.P., Lee K.W., Kwan P.S., Castilho A.G., Ng I.O.L., Man K., Wong N., To K.F., Zheng B., Lai P.B.S., Lo C.M., Chan K.W. and Guan X.Y., miR-130b promotes CD133(+) liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1, Cell Stem Cell. 2010, 7(6): 694-707.

Ma S.K.Y., Chan Y.P., Kwan P.S., Lee K.W., Yan M., Tang K.H., Ling M.T., Vielkind J.R., Guan X. and Chan K.W., microRNA-616 induces androgen-independent growth of prostate cancer cells by suppressing expression of tissue factor pathway inhibitor TFPI-2, Cancer Research. 2011, 71: 583-92.

Tang K.H., Ma S.K.Y., Kwan P.S., Chan Y.P., Lee K.W., Ng I.O.L., Guan X. and Chan K.W., CD133+ liver tumor-initiating cells promote tumor growth, angiogenesis and self-renewal through activation of the neurotensin / interleukin-8 signaling cascade, American Association for Cancer Reseach - Annual Meeting 2011.

Tong D.K.H., Law S.Y.K., Kwong D.L.W., Chan K.W., Lam A.K.Y. and Wong K.H., Histological regression of squamous esophageal carcinoma assessed by percentage of residual viable cells after neoadjuvant chemoradiation is an important prognostic factor, Ann Surg Oncol. 2010, 17(8): 2184-92.

Wong V.C., Ko J.M.Y., Qi R.Z., Li P.J., Wang L.D., Li J.L., Chan Y.P., Chan K.W., Stanbridge E.J. and Lung M.L., Abrogated expression of DEC1 during oesophageal squamous cell carcinoma progression is age- and family history-related and significantly associated with lymph node metastasis, British journal of cancer. 2011, 104(5): 841-9.

Wong V.C., Chen H., Ko J.M.Y., Chan K.W., Chan Y.P., Law S.Y.K., Chua D.T.T., Kwong D.L.W., Lung H.L., Srivastava G., Tang J.C., Tsao G.S.W., Zabarovsky E.R., Stanbridge E.J. and Lung M.L., Tumor suppressor dual-specificity phosphatase 6 (DUSP6) impairs cell invasion and epithelial-mesenchymal transition (EMT)-associated phenotype, International journal of cancer. . 2011.

Yuen H.F., Chan Y.K., Grills C., McCrudden C.M., Gunasekharan V., Shi Z., Wong S.Y., Lappin T.R., Chan K.W., Fennell D.A., Khoo U.S., Johnston P.G. and El-Tanani M., Polyomavirus enhancer activator 3 protein promotes breast cancer metastatic progression through Snail-induced epithelial-mesenchymal transition, J Pathol. 2011, 224(1): 78-89.

Yuen H.F., McCrudden C.M., Chan K.K., Chan Y.P., Wong M.L.Y., Chan Y.K., Khoo U.S., Law S., Srivastava G., Lappin T.R., Chan K.W. and El-Tanani M., The role of pea3 group transcription factors in esophageal squamous cell carcinoma, Am J Pathol. 2011, 179 (2): 992-1003.

Researcher : Chan LC

Project Title:	To develop a pilot humanities program in the first year undergraduate medical curriculum 2007-2008.
Investigator(s):	Chan LC
Department:	Pathology
Source(s) of Funding:	Leung Kau Kui Research and Teaching Endowment Fund - Teaching Grants
Start Date:	08/2007

Project Title:	The 7th Asia Pacific IAP Congress 2011 Professionalism and the practice of Pathology - Key Issues and Challenges
Investigator(s):	Chan LC
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Grants for Teaching Staff
Start Date:	05/2011

List of Research Outputs

Chan L.C., Experiences Learned in the past – Improving the efficiency and effectiveness of PBL in medical education, 1st Asia-Pacific Joint PBL Conference 2010. Taipei. 23 October 2010 . 2010.

Chan L.C., Guest speak, Symposium and Photo Exhibition - Suffering to Well-being. An initiative of the Task Force for Humanities in Medicine. Organized by Department of Family Medicine & Primary Care with the support of the LKS Faculty of Medicine Development Fund for Medical Humanities & the Centre for the Humanities & Medicine. 27 May 2011 . 2011.

Chan L.C., Mindfulness and medical humanities, Centre for Biomedical Ethics, National University of Singapore. Singapore. 6 May 2011. 2011.

Chan L.C., Moderator and Poster Reviewer during the conference, 1st Asia-Pacific Joint PBL Conference 2010. Taipei. 23 October 2010 . 2010.

Chan L.C., PBL in General Education – Engaging and empowering student learning through PBL, 1st Asia-Pacific Joint PBL Conference 2010. Taipei. 23 October 2010 . 2010.

Chan L.C., Professionalism and the practice of pathology – key issues and challenges, 7th Asia Pacific IAP Congress 2011. Taipei. 21 May 2011. 2011.

Chan L.C., Sowing the seeds of social responsibility and accountability – medical humanities show the way, 8th Asia Pacific Medical Education Conference (APMEC). Singapore. 29 January 2011 . 2011.

Chan L.C., Talk on Humanities, Faculty Orientation for All Freshmen (new MBBS students), Li Ka Shing Faculty of Medicine, September 2010 . 2010.

Chan L.C., Beh S.L. and Yip Y.N., Young Chinese medical students adapt well to problem-based learning, Medical Teacher. 2011, 33: 506.

Chen J.Y., Salter Menzo D.J. and Chan L.C., Pen, brush and camera: outcomes-based medical humanities, In: Kevin Eva, Medical Education. 2010, 44: 1139.

Farrell J.J., Sherva R.M., Chen Z.Y., Luo H.Y., Chu B.F., Ha S.Y., Li C.K., Lee A.C., Li R.C., Li C.K., Yuen H.L., So J.C.C., Ma E.S.K., Chan L.C., Chan V.N.Y., Sebastiani P., Farrer L.A., Baldwin C.T., Steinberg M.H. and Chui D.H., A 3-bp deletion in the HBS1L-MYB intergenic region on chromosome 6q23 is associated with HbF expression, Blood. 2011, 117(18): 4935-45.

Leung T.W., Yip S.F., Lam C.W., Chan T.L., Lam W.W., Siu D.Y., Fan Y.H., Chan N.P., Liu H.S., Chan L.C. and Wong K.S., Genetic predisposition of white matter infarction with protein S deficiency and R355C mutation, Neurology. 2010, 75(24): 2185-9.

So C.C., Leung Y.Y., Yip S.F., Chan S.Y., Lam C.C., Chan G.C.F., Chim S. and Chan L.C., Common association of haemolytic uraemic syndrome with invasive Streptococcus pneumoniae infection in five Chinese paediatric patients, Hong Kong Med J. 2011 Jun;17(3):237-41. 2011.

So J.C.C., Leung R.Y.Y., Yip S.F., Chan S.Y., Lam C.C.K., Chan G.C.F., Chim S. and Chan L.C., Common association of haemolytic uraemic syndrome with invasive Streptococcus pneumoniae infection in five Chinese paediatric patients, Hong Kong Med J. 2011, 17(3): 237-41.

So J.C.C., Chan A.Y.Y., Chow E.Y.D., Lin S.Y., Yip S.F., Szeto S.C. and Chan L.C., Haemoglobin Bonn in a Chinese family as a cause of spurious hypoxaemia measured by pulse oximetry, J Clin Pathol. 2010, 63(10): 947-9.

So J.C.C., Chan A.Y.Y., Luo H.Y., Verhovsek M., Chui D.H., Ling S.C. and Chan L.C., Hb A2 Hong Kong - A novel δ-globin variant in a Chinese family masks the diagnosis of β-thalassemia trait, Hemoglobin. 2010, 35(2): 162-5.

Researcher : Chan LK

Project Title:	Molecular dissection of the functional association of the PTEN and DLC1 tumor suppressors
Investigator(s):	Chan LK, Ng IOL
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	03/2011

List of Research Outputs

Ko F.C.F., Chan L.K., Tung K.K., Scott S.W., Ng I.O.L. and Yam J.W.P., Akt phosphorylation of deleted in liver cancer 1 abrogates its suppression of liver cancer tumorigenesis and metastasis., Gastroenterology. Elsevier Inc., 2010, 139: 1397-1407.e6.

Ko F.C.F., Chan L.K., Ng I.O.L. and Yam J.W.P., PKA Phosphorylation of Deleted in Liver Cancer 1 (DLC1) at serine-549 modulates its inhibitory activity in liver cancer tumourigenesis, The 3rd JCA-AACR Special Joint Conference, Chiba, Japan. 2011.

Researcher : Chan QKY

List of Research Outputs

Siu K.Y., Wong E.S.Y., Chan H.Y., Kong S.H., Woo N.W., Tam K.F., Ngan H.Y.S., Chan Q.K.Y., Chan D.C., Chan Y.K. and Cheung A.N.Y., Differential expression and phosphorylation of Pak1 and Pak2 in ovarian cancer: effects on prognosis and cell invasion, International Journal of Cancer. 2010.

Researcher : Chan TL

Project Title:	Molecular characterisation of the serrated neoplasia pathway and its role in the development of colorectal cancer with mismatch repair deficiency
Investigator(s):	Chan TL, Leung SY, Yuen ST
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2005

Project Title:	Expression of microRNAs in various stages and pathways of colorectal carcinogenesis
Investigator(s):	Chan TL, Leung SY, Yuen ST
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2007
Completion Date:	12/2010

Project Title:	The Role and Mechanism of CpG Island Methylator Phenotype (CIMP) in Early-Onset Colorectal Cancer
Investigator(s):	Chan TL
Department:	Pathology
Source(s) of Funding:	Michael and Betty Kadoorie Cancer Genetics Research Programme (MBKCGRP) II
Start Date:	01/2008

Project Title:	Study of the mechanisms underlying heritable germline epimutation of MSH2 in Hereditary Nonpolyposis Colorectal Cancer
Investigator(s):	Chan TL, Leung SY, Yuen ST
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	08/2008
Completion Date:	01/2011

Project Title:	Outstanding Young Researcher Award 2007-2008
Investigator(s):	Chan TL
Department:	Pathology
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	10/2008

Project Title:	The Genome Wide Epigenetic study of Early-onset Colorectal Cancer Patients with CpG Island Methylator Phenotype (CIMP)
Investigator(s):	Chan TL
Department:	Pathology
Source(s) of Funding:	Germany/Hong Kong Joint Research Scheme
Start Date:	01/2010

List of Research Outputs

Kempers M.J., Kuiper R.P., Ockeloen C.W., Chappuis P.O., Hutter P., Rahner N., Schackert H.K., Steinke V., Holinski-Feder E., Morak M., Kloor M., Büttner R., Verwiel E.T., van Krieken J.H., Nagtegaal I.D., Goossens M., van der Post R.S., Niessen R.C., Sijmons R.H., Kluijt I., Hogervorst F.B., Leter E.M., Gille J.J., Aalfs C.M., Redeker E.J., Hes F.J., Tops C.M., van Nesselrooij B.P., van Gijn M.E., Gómez García E.B., Eccles D.M., Bunyan D.J., Syngal S., Stoffel E.M., Culver J.O., Palomares M.R., Graham T., Velsher L., Papp J., Oláh E., Chan T.L., Leung S.Y., van Kessel A.G., Kiemeney L.A., Hoogerbrugge N. and Ligtenberg M.J., Risk of colorectal and endometrial cancers in EPCAM deletion-positive Lynch syndrome: a cohort study, Lancet Oncol. 2010, 12(1): 49-55.

Kuiper R.P., Vissers L.E., Venkatachalam R., Bodmer D., Hoenselaar E., Goossens M., Haufe A., Kamping E., Niessen R.C., Hogervorst F.B., Gille J.J., Redeker B., Tops C.M., van Gijn M.E., van den Ouweland A.M., Rahner N., Steinke V., Kahl P., Holinski-Feder E., Morak M., Kloor M., Stemmler S., Betz B., Hutter P., Bunyan D.J., Syngal S., Culver J.O., Graham T., Chan T.L., Nagtegaal I.D., van Krieken J.H., Schackert H.K., Hoogerbrugge N., van Kessel A.G. and Ligtenberg M.J., Recurrence and variability of germline EPCAM deletions in Lynch syndrome, Hum Mutat.. 2011, 32: 407-414.

Leung T.W., Yip S.F., Lam C.W., Chan T.L., Lam W.W., Siu D.Y., Fan Y.H., Chan N.P., Liu H.S., Chan L.C. and Wong K.S., Genetic predisposition of white matter infarction with protein S deficiency and R355C mutation, Neurology. 2010, 75(24): 2185-9.

Researcher : Chan WL

List of Research Outputs

Teoh K.T., Siu Y.L., Chan W.L., Schlüter M.A., Liu C.J., Peiris J.S.M., Bruzzone R., Margolis B. and Nal-Rogier B.T.M., The SARS coronavirus E protein interacts with PALS1 and alters tight junction formation and epithelial morphogenesis., In: Asma Nusrat, Molecular Biology of the Cell. 2010, 21: 3838-3852.

Researcher : Chan WY

Project Title:	Establishment of primary human conjunctival epithelial cell in vitro and conjunctiva ex vivo organ culture model to study human infection of influenza virus.
Investigator(s):	Chan WY, Peiris JSM, Nicholls JM
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	10/2009
Completion Date:	03/2011

Project Title:	The biological and genetic determinants of seasonal influenza A virus replication in the lower respiratory tract
Investigator(s):	Chan WY, Chan MCW, Yen H, Nicholls JM, Peiris JSM
Department:	Pathology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	02/2011

List of Research Outputs

Chan M.C.W., Chan W.Y., Yen H., Yu C.L., Yuen K.M., Tang L.L.S., Li C.L., Kang S.R., Hui F.F., Lai W.W.K., Sihoe A.D.L., Guan Y., Nicholls J.M. and Peiris J.S.M., ) Tropism and innate host response of the 2009 pandemic H1N1 influenza virus compared with related swine influenza viruses and reassortants in ex vivo and in vitro cultures of the human respiratory tract and conjunctiva, Options for the Control of Influenza VII, 2010.

Chan M.C.W., Chan W.Y., Yen H., Lee M.Y., Guan Y., Nicholls J.M. and Peiris J.S.M., Comparing the tropism of the pandemic H1N1/2009 influenza virus with seasonal influenza virus, related swine influenza viruses and reassortants in ex vivo and in vitro cultures of human conjunctiva and respiratory tract., 4th Annual Center of Excellence for Influenza Research and Surveillance Network Meeting, Woodcliff Hotel and Conference Center 199 Woodcliff Drive, Fairport, NY 14450 . 2010.

Chan M.C.W., Chan W.Y., Lee J.W., Fang X., Matthay M.A. and Peiris J.S.M., Impaired alveolar edema fluid clearance in human alveolar epithelial cells injured by severe influenza A virus infection, Keystone Symposia 2011 - Pathogenesis of influenza: virus-host interaction. 2011.

Chan M.C.W., Chan W.Y., Lee M.Y., Cheung C.Y., Nicholls J.M. and Peiris J.S.M., Pathogenesis of swine-origin influenza H1N1 virus (S-OIV) in humans: studies of viral tropism and host response in primary differentiated human respiratory epithelial cell cultures in vitro and in ex vivo, Health Research Symposium 2010.

Chan M.C.W., Chan W.Y., Yen H., Yu C.L., Yuen K.M., Tang L.L.S., Li C.L., Kang S.R., Hui F.F., Lai W.W.K., Sihoe A.D.L., Guan Y., Nicholls J.M. and Peiris J.S.M., Tropism and innate host response of the 2009 pandemic H2N2 influenza virus compared with related swine influenza viruses and reassortants in ex vivo and in vitro cultures of the human respiratory tract and conjunctiva, Influenza and other respiratory viruses. 2011, 5 (S1): 54-55.

Chan W.Y., Kang S.R., Yu C.L. and Chan M.C.W., Effect of vitamin B2 in the treatment of human influenza H5N1 virus infection: studies in vitro and in vivo. , Health Research Symposium 2010.

Chan W.Y., Chan M.C.W., Li S.Y., Nicholls J.M. and Peiris J.S.M., Neutrophil extracellular trap formation in acute influenza virus infection, Keystone Symposia 2011 - Pathogenesis of influenza: virus-host interaction, 2011 . 2011.

Chan W.Y., Hui F.F., Kang S.R., Yu C.L., Nicholls J.M. and Chan M.C.W., Replication and innate host response of influenza A virus in human lung microvascular endothelial cells: insights into systemic dissemination and pathogenesis , Options for the Control of Influenza VII. 2010.

Chan W.Y., Yuen K.M., Yu C.L., Tang L.L.S., Li C.L., Nicholls J.M. and Chan M.C.W., Replication of avian and seasonal influenza viruses in human bronchus and lung, Influenza and other respiratory viruses. 2011, 5: 425-426.

Chan W.Y., Chan M.C.W., Nicholls J.M. and Peiris J.S.M., Replication of avian and seasonal influenza viruses in human bronchus and lung, Options for the Control of Influenza VII. 2010.

Chan W.Y., Young Scientist Award (Life Science), The Hong Kong Institution of Science. 2010.

Hui F.F., Chan W.Y., Fung K.H.Y., Yu C.L., Tsao G.S.W., Chan M.C.W. and Nicholls J.M., The regional distribution of different types of influenza receptors in cultured human alveolar epithelial cells and correlation with in vitro infection, Influenza and other respiratory viruses. 2011, 5(S1): 436-437.

Jia D., Rahbar R., Chan W.Y., Lee M.Y., Chan M.C.W., Wang B.X., Baker D.P., Sun B., Peiris J.S.M., Nicholls J.M. and Fish E.N., Influenza virus non-structural protein 1 (NS1) disrupts interferon signaling. , PLoS One. 2010, 5 (11): e13927.

Lee M.Y., Chan W.Y., Gardy D.L., Lo C.K., Sihoe A.D.L., Kang S.R., Cheung K.W., Guan Y., Chan M.C.W., Hancock R.E. and Peiris J.S.M., Systems-level comparison of host responses induced by pandemic and seasonal influenza A H1N1 viruses in primary human type I-like alveolar epithelial cells in vitro, Respiratory Research. 2010, 11: 147.

Leung C.Y.H., Nicholls J.M., Sia S.F., Hui P.Y., Cheung P.P.H., Chow C.K., Chan W.Y., Chan M.C.W. and Peiris J.S.M., Toll-like Receptor 3 signaling contributes to enhanced disease severity in H5N1 but not pandemic H1N1 infection in mice, Keystone Symposia on Molecular and Cellular Biology: Pathogenesis of Influenza: virus-host interactions. 2011.

Li C.L., Chan W.Y., Hui F.F., Kang S.R., Yu C.L., Nicholls J.M. and Chan M.C.W., Replication and innate host response of influenza A virus in lung microvascular endothelial cells: new insights into systemic infection and pathogenesis, Influenza and other respiratory viruses. 2011, 5 (S1): 287-288.

Nicholls J.M., Chan W.Y., Li C.L., Walther T.J. and Haslam S.T.U.A.R.T., Receptors in the Human Respiratory Tract - Making and Breaking the Links, Keystone Symposia on Molecular and Cellular Biology: Pathogenesis of Influenza: virus-host interactions. 2011.

Peiris J.S.M., Chan M.C.W., Chan W.Y. and Nicholls J.M., Human ex vivo and in vitro Experimental Models for Studying Influenza Pathogenesis, Keystone Symposia on Molecular and Cellular Biology: Pathogenesis of Influenza: virus-host interactions. 2011.

Yen H., Liang C., Wu C., Forrest H., Ferguson A., Choy K.T., Jones J., Wong D.D.Y., Cheung P.H.P., Hsu C., Li O.T.W., Yuen K.M., Chan W.Y., Poon L.L.M., Chan M.C.W., Nicholls J.M., Krauss S., Wong C.H., Guan Y., Webster R.G., Webby R. and Peiris J.S.M., Hemagglutinin-neuraminidase balance confers respiratory droplet transmissibility of the pandemic H1N1 influenza virus in ferrets, Keystone Symposia (Pathogenesis of Influenza: Virus-Host Interactions), May 23-28, 2011, Hong Kong SAR. 2011.

Yu C.L., Chan W.Y., Wang J., Nicholls J.M., Peiris J.S.M., Mason R.J. and Chan M.C.W., Avian influenza H5N1 and seasonal H1N1 virus infection and innate host responses in human alveolar type II epithelial cells and macrophages, Options for the Control of Influenza VII. 2010.

Yuen K.M., Chan W.Y., Mok K.P., Wong A.C.N., Kang S.R., Nicholls J.M. and Chan M.C.W., Differential onset of apoptosis in avian influenza H5N1 and seasonal H1N1 virus infected human bronchial and alveolar epithelial cell, an in vitro and ex vivo study, Options for the Control of Influenza VII. 2010.

Yuen K.M., Chan W.Y., Mok K.P., Wong C.N., Kang S.R., Nicholls J.M. and Chan M.C.W., Differential onset of apoptosis in avian influenza H5N1 and seasonal H1N1 virus infected human bronchial and alveolar epithelial cells: an in vitro and ex vivo study, Influenza and other respiratory viruses. 2011, 5 (S1): 437-438.

Researcher : Chan YK

Project Title:	Characterization of BRCA2 Variants of Unknown Significance and Mutations
Investigator(s):	Chan YK, Khoo US
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2009
Completion Date:	01/2011

Project Title:	Validating and examining SNPs identified from genome-wide scanning for disease susceptibility to HBV-related liver cancer in Chinese population
Investigator(s):	Chan YK, Ng IOL, Wong CM
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2010

List of Research Outputs

Cai Q., Wen W., Qu S., Li G., Egan K.M., Chen K., Deming S.L., Shen H., Shen C.Y., Gammon M.D., Blot W.J., Matsuo K., Haiman C.A., Khoo U.S., Iwasaki M., Santella R.M., Zhang L., Fair A.M., Hu Z., Wu P.E., Signorello L.B., Titus-Ernstoff L., Tajima K., Henderson B.E., Chan Y.K., Kasuga Y., Newcomb P.A., Zheng H., Cui Y., Wang F., Shieh Y.L., Iwata H., Le Marchand L., Chan S.Y., Shrubsole M.J., Trentham-Dietz A., Tsugane S., Garcia-Barcelo M.M., Long J., Li C., Shi J., Huang B., Xiang Y.B., Gao Y.T., Lu W., Shu X.O. and Zheng W., Replication and functional genomic analyses of the breast cancer susceptibility locus at 6q25.1 generalize its importance in women of chinese, Japanese, and European ancestry, Cancer Res. 2011, 71(4): 1344-55.

Chan Y.K., Xu M., Ching J.C.Y., Chan V.S.F., Ip Y.C., Yam L., Chu C.M., Lai S.T., So K.M., Wong T.Y., Chung P.H., Tam P., Yip S.P., Sham P.C., Lin C., Leung G.M., Peiris J.S.M. and Khoo U.S., Association of a single nucleotide polymorphism in the CD209 (DC-SIGN) promoter with SARS severity, Hong Kong Med J. 2010, 16(5 Suppl 4): 37-42.

Chan Y.K., Xu M.S., Ching C.Y.J., So T.M., Lai S.T., Chu C.M., Yam L.Y., Wong A.T., Chung P.H., Chan V.S.F., Lin C.L., Sham P.C., Leung G.M., Peiris J.S.M. and Khoo U.S., CD209 (DC-SIGN) -336A>G promoter polymorphism and severe acute respiratory syndrome in Hong Kong Chinese, Hum Immunol. 2010, 71(7): 702-7.

Chan Y.K., PLoS ONE. 2010.

Chen J., Gomes A.R., Monteiro L.J., Wong S.Y., Wu L.H., Ng T.T., Karadedou C.T., Millour J., Ip Y.C., Cheung Y.N., Sunters A., Chan Y.K., Lam E.W. and Khoo U.S., Constitutively nuclear FOXO3a localization predicts poor survival and promotes Akt phosphorylation in breast cancer, PLoS One. 2010, 5(8): e12293.

Khoo U.S., Zhang L., Cheung Y.N., Chan Y.K., Ip Y.C., Wong S.U. and Tsang W.H., Splice variant profiling of tamoxifen sensitive and resistance breast cancer, 27th HUGO-IABCR Congress 2010, Singapore. 2010.

Khoo U.S., Ching J.C.Y., Chan Y.K., Xu M., So K.M., Lai S.T., Chu C.M., Yam L., Wong T.Y., Chung P.H., Chan V.S.F., Tam P.K.H., Yip S.P., Lin C.L., Sham P.C., Leung G.M. and Peiris J.S.M., The CD209 (DC-SIGN) -336A>G and MxA -123C>A promoter polymorphisms in Severe Acute Respiratory Syndrome Coronavirus infection in Hong Kong Chinese, Health Research Symposium 2010: “Improving health and recognising excellence, Hong Kong. 2010.

Siu K.Y., Wong E.S.Y., Chan H.Y., Kong S.H., Woo N.W., Tam K.F., Ngan H.Y.S., Chan Q.K.Y., Chan D.C., Chan Y.K. and Cheung A.N.Y., Differential expression and phosphorylation of Pak1 and Pak2 in ovarian cancer: effects on prognosis and cell invasion, International Journal of Cancer. 2010.

Yuen H.F., Chan Y.K., Grills C., McCrudden C.M., Gunasekharan V., Shi Z., Wong S.Y., Lappin T.R., Chan K.W., Fennell D.A., Khoo U.S., Johnston P.G. and El-Tanani M., Polyomavirus enhancer activator 3 protein promotes breast cancer metastatic progression through Snail-induced epithelial-mesenchymal transition, J Pathol. 2011, 224(1): 78-89.

Yuen H.F., McCrudden C.M., Chan K.K., Chan Y.P., Wong M.L.Y., Chan Y.K., Khoo U.S., Law S., Srivastava G., Lappin T.R., Chan K.W. and El-Tanani M., The role of pea3 group transcription factors in esophageal squamous cell carcinoma, Am J Pathol. 2011, 179 (2): 992-1003.

Researcher : Chan YP

List of Research Outputs

Chan S.H.K., Ko J.M.Y., Chan K.W., Chan Y.P., Tao Q., Hyytiainen M., Keski-Oja J., Law S.Y.K., Srivastava G., Tang J., Tsao G.S.W., Chen H., Stanbridge E.J. and Lung M.L., The ECM portein LTBP-2 is a suppressor of esophageal squamous cell carcinoma tumor formation but higher tumor expression associates with poor patient outcome, International Journal of Cancer. 2011, 129: 565-573.

Ma S.K.Y., Kwan P.S., Chan Y.P., Fu L., Tang K.H., Tong M., Chan K.W. and Guan X., RNA-Seq identifies protein tyrosine kinase 6 (PTK6) as a candidate tumor-suppressor gene in esophageal squamous cell carcinoma , American Association for Cancer Research - Annual Meeting 2011.

Ma S.K.Y., Tang K.H., Chan Y.P., Lee K.W., Kwan P.S., Castilho A.G., Ng I.O.L., Man K., Wong N., To K.F., Zheng B., Lai P.B.S., Lo C.M., Chan K.W. and Guan X.Y., miR-130b promotes CD133(+) liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1, Cell Stem Cell. 2010, 7(6): 694-707.

Ma S.K.Y., Chan Y.P., Kwan P.S., Lee K.W., Yan M., Tang K.H., Ling M.T., Vielkind J.R., Guan X. and Chan K.W., microRNA-616 induces androgen-independent growth of prostate cancer cells by suppressing expression of tissue factor pathway inhibitor TFPI-2, Cancer Research. 2011, 71: 583-92.

Tang K.H., Ma S.K.Y., Kwan P.S., Chan Y.P., Lee K.W., Ng I.O.L., Guan X. and Chan K.W., CD133+ liver tumor-initiating cells promote tumor growth, angiogenesis and self-renewal through activation of the neurotensin / interleukin-8 signaling cascade, American Association for Cancer Reseach - Annual Meeting 2011.

Wong V.C., Ko J.M.Y., Qi R.Z., Li P.J., Wang L.D., Li J.L., Chan Y.P., Chan K.W., Stanbridge E.J. and Lung M.L., Abrogated expression of DEC1 during oesophageal squamous cell carcinoma progression is age- and family history-related and significantly associated with lymph node metastasis, British journal of cancer. 2011, 104(5): 841-9.

Wong V.C., Chen H., Ko J.M.Y., Chan K.W., Chan Y.P., Law S.Y.K., Chua D.T.T., Kwong D.L.W., Lung H.L., Srivastava G., Tang J.C., Tsao G.S.W., Zabarovsky E.R., Stanbridge E.J. and Lung M.L., Tumor suppressor dual-specificity phosphatase 6 (DUSP6) impairs cell invasion and epithelial-mesenchymal transition (EMT)-associated phenotype, International journal of cancer. . 2011.

Yuen H.F., McCrudden C.M., Chan K.K., Chan Y.P., Wong M.L.Y., Chan Y.K., Khoo U.S., Law S., Srivastava G., Lappin T.R., Chan K.W. and El-Tanani M., The role of pea3 group transcription factors in esophageal squamous cell carcinoma, Am J Pathol. 2011, 179 (2): 992-1003.

Researcher : Chen J

List of Research Outputs

Chen J., Gomes A.R., Monteiro L.J., Wong S.Y., Wu L.H., Ng T.T., Karadedou C.T., Millour J., Ip Y.C., Cheung Y.N., Sunters A., Chan Y.K., Lam E.W. and Khoo U.S., Constitutively nuclear FOXO3a localization predicts poor survival and promotes Akt phosphorylation in breast cancer, PLoS One. 2010, 5(8): e12293.

Researcher : Chen SPL

List of Research Outputs

Chen S.P.L., Poon D.W.T., Mak C.M., Kwong Y.L., Chan A.Y.W. and Tam S., Application of pharmacogenetics: UGT1A1*28 and nilotinib-induced unconjugated hyperbilirubinaemia in a patient with chronic myeloid leukaemia, Pathology. 2011, 43(3): 273-4.

Lee H.H.C., Mak C.M., Lam C.W., Yuen L.Y.P., Chan A.O.K., Shek C.C., Siu T.S., Lai C.K., Ching D.C.K., Siu C.W.K., Chen S.P.L., Law C.Y., Tai M.H.L., Tam S. and Chan A.Y.W., Analysis of inborn errors of metabolism: disease spectrum for expanded newborn screening in Hong Kong, Chinese Medical Journal (English Edition). 2011, 124(7): 983-9.

Researcher : Chen WYW

Project Title:	Doris Zimmern HKU-Cambridge Hughes Hall Fellowships 2010-11
Investigator(s):	Chen WYW
Department:	Pathology
Source(s) of Funding:	Doris Zimmern HKU-Cambridge Hughes Hall Fellowships
Start Date:	09/2010

Project Title:	Anti-tumor effects of IL2Rα (CD25) antagonists, either as single agents or in combination with a proteasome inhibitor, Bortezomib in NK-cell malignancies
Investigator(s):	Chen WYW, Srivastava G
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	02/2011

List of Research Outputs

Dong G., Chanudet E., Zeng N., Appert A., Chen W.Y.W., Au W.Y., Hamoudi R., Watkins A.J., Ye H., Liu H., Gao Z., Chuang S.S., Srivastava G. and Du M.Q., A20, ABIN-1/2 and CARD11 mutations and their prognostic value in gastrointestinal diffuse large B-cell lymphoma, Clin Cancer Res. 2011, [Epub ahead of print].

Zeng N., Dong G., Bi Y., Chanudet E., Huang Y., Appert A., Chen W.Y.W., Au W.Y., Hamoudi R.A., Watkins A.J., Ye H., Liu H., Zhu X., Zou L., Chen R., Gao Z., Chuang S.S., Srivastava G. and Du M.Q., Genetic abnormalities of NF-kB regulators in ocular adnexal MALT lymphoma and gastrointestinal DLBCL, The 3rd UK & Ireland NF-kB meeting. 2011.

Researcher : Cheung ANY

Project Title:	Selecting most suitable students for production of best medical doctors-which criteria should we use?
Investigator(s):	Cheung ANY, Patil NG, Ip MSM, Chan LC
Department:	Pathology
Source(s) of Funding:	Leung Kau Kui Research and Teaching Endowment Fund - Teaching Grants
Start Date:	02/2005

Project Title:	Folate and folate receptor alpha in ovarian cancers
Investigator(s):	Cheung ANY, Siu KY
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2007

Project Title:	Akt and p21-activated kinase signaling pathways in gestational trophoblastic disease
Investigator(s):	Cheung ANY, Ngan HYS, Siu KY
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2007

Project Title:	Cervical cancer screening by enhanced cervical cytology-application of novel markers
Investigator(s):	Cheung ANY, Ngan HYS, Guan X
Department:	Pathology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	03/2007

Project Title:	Centre for Research into Circulating Fetal Nucleic Acids
Investigator(s):	Cheung ANY
Department:	Pathology
Source(s) of Funding:	Areas of Excellence Scheme
Start Date:	01/2008

Project Title:	Tropomyosin-related kinase B and Brain-derived neurotrophic factor in ovarian cancer
Investigator(s):	Cheung ANY, Siu KY, Ngan HYS
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2008

Project Title:	FBI-1 in ovarian carcinogenesis and progression
Investigator(s):	Cheung ANY, Siu KY, Ngan HYS
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2009

Project Title:	HPV detection as an adjunct for triage of atypical cervical cytology in screening for cervical cancer
Investigator(s):	Cheung ANY
Department:	Pathology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	11/2009

Project Title:	Hedgehog pathway regulator Kif7 in gestational trophoblastic disease
Investigator(s):	Cheung ANY, Ngan HYS, Siu KY, Wong GW
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2010

Project Title:	DOCK180 in ovarian cancer progression
Investigator(s):	Cheung ANY, Siu KY
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2011

Project Title:	7th Asia Pacific IAP Congress HPV testing: Application on gynecological cytology Differential Diagnosis of Molar Lesions
Investigator(s):	Cheung ANY
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Grants for Teaching Staff
Start Date:	05/2011
Completion Date:	05/2011

List of Research Outputs

Chan D.W., Liu V.W.S., Leung L.Y., Yao K.M., Chan K.K.L., Cheung A.N.Y. and Ngan H.Y.S., Zic2 synergistically enhances Hedgehog signalling through nuclear retention of Gli1 in cervical cancer cells, In: Peter A Hall, Journal of Pathology. Pathological Society of Great Britain an, John Wiley & Sons, Ltd, 2011, 225: 525-34.

Chan K.H., Zhang J., To K.K.W., Chan C.S., Poon K.M., Guo K., Ng F., Zhang Q., Leung H.C., Cheung A.N.Y., Lau C.Y., Woo P.C.Y., Tse H., Wu W.L., Chen H., Zheng B. and Yuen K.Y., Wild type and mutant 2009 pandemic influenza A (H1N1) viruses cause more severe disease and higher mortality in pregnant BALB/c mice, PLoS One. 2010, 5: e13757.

Cheung A.N.Y., 1. HPV testing in cervical cytology & 2. HPV testing. The example on gynecological cytology, The 7th Asia Pacific IAP Congress, May 20-24, 2011, Taiwan.. 2011.

Cheung A.N.Y., 1. New Bethesda Consensus and Screening Recommendation after Introduction of HPV Vaccines & 2. New Molecular Marker in Prediction of HGSIL, Asia Oceania (research organisation on) Genital Infections & Neoplasia (AOGIN), Bali, Indonesia, 17-19 March 2011. 2011.

Cheung A.N.Y., Lo C.L.R., Ho S.L., Kong P.L., Tipoe G. and Beh S.L., MULTI-MEDIA DIGITAL TUTORIAL FOR MEDICAL EDUCATION, Frontiers in Health and Medical Sciences Education HKU 2010.

Cheung A.N.Y., Wong G.W., Yang M.S., Tsang C.H., Ji S.L., Szeto E.F., Wong E.S.Y. and Ngan H.Y.S., Microarray-in-microwell HPV Profiling of Atypical Squamous cells of Undetermined Significance in an Asian Screening Population , 26th International Papillomavirus Conference, Montreal, Canada. 2010.

Cheung A.N.Y., Microarray-in-microwell HPV Profiling of Atypical Squamous cells of Undetermined Significance, Asian Screening Population. 26th International Papillomavirus Conference & Clinical and Public Health Workshops, 2-8 July. 2010.

Cheung A.N.Y., Molecular Markers for Cervical Cancer Detection, International Peace Maternity & Child Health Hospital of the China Welfare Institute, July 9, 2010, Shanghai. 2010.

Cheung A.N.Y., Molecular Markers for Cervical Cancer Detection, Cancer Hospital of Shantou University Medical College, September 26, 2010, Shantou. 2010.

Cheung A.N.Y., Molecular markers for cervical cancer detection: Gene loci specific studies in liquid based cervical cytology, 17th Hong Kong International Cancer Congress, 3-5 November. 2010.

Cheung A.N.Y., The role of HPV testing in clinical setting • Types of HPV test • Clinical applications , HPV Asia Pacific Forum, Singapore, 14-15 April, 2011. 2011.

Cheung A.N.Y., Update on the cytology and histology of cervical premalignant and malignant lesions, First annual scientific meeting of OGSHK jointly organized by OGSHK, HKSRM, HKSCCP and HKGES, 22 August. 2010.

Cheung L.W., Mak A.S., Cheung A.N.Y., Ngan H.Y.S., Leung P.C. and Wong A.S.T., P-cadherin cooperates with insulin-like growth factor-1 receptor to promote metastatic signaling of gonadotropin-releasing hormone in ovarian cancer via p120 catenin, Oncogene. 2011, 30: 2964-2974.

Ip K.M., Cheung A.N.Y., Ngan H.Y.S. and Wong A.S.T., p70 S6 kinase in the control of actin cytoskeleton dynamics and directed migration of ovarian cancer cells, Oncogene. 2011, 30: 2420-2432.

Jiang L., Siu K.Y., Wong G.W., Tam K.F., Ngan H.Y.S., Wong S.Y., Chan H.Y. and Cheung A.N.Y., Overexpression of proto-oncogene FBI-1 activates membrane type 1-matrix metalloproteinase in association with adverse outcome in ovarian cancers., Molecular cancer. 2010, 9: 318.

Kwan T.T.C., Cheung A.N.Y., Lo S.S., Lee P.W., Tam K.F., Chan K.K.L. and Ngan H.Y.S., Psychological burden of testing positive for HPV on women with atypical cervical cytology: a prospective study, Acta Obstet Gynecol Scand, Feb 5. 2011, 90(5): 445-51.

Kwan T.T.C., Cheung A.N.Y., Lo S.S., Lee P.W.H., Tam K.F., Chan K.K.L. and Ngan H.Y.S., Psychological burden of testing positive for high-risk human papillomavirus on women with atypical cervical cytology: a prospective study, Acta Obstetricia et Gynecologica Scandinavica. 2011, 90(5): 445-51.

Leung T.H.Y., Chan K.K.L., Chan D.W., Cheung A.N.Y. and Ngan H.Y.S., Interaction of DNp73 and C35 promotes chemoresistance in ovarian cancer cells, 23rd Lorne Cancer Conference, Melbourne, Australia. 2011.

Leung T.W., Liu S., Cheung A.N.Y. and Ngan H.Y.S., Expression of Notch 1 protein in cervical cancer and its correlation with Human Papillomavirus (HPV) infection., 17th Hong Kong International Cancer Congress. Nov. 2010.

Leung T.W., Liu S., Cheung A.N.Y. and Ngan H.Y.S., Hypermethylation of HPV 16/18 E2 binding sites 1&2 is associated with Hypermethylation of HPV 16/18 E2 binding sites 1&2 is associated with better survival in cervical cancer , 26th International Papillomavirus Conference, 223, Montreal Canada, July 3-8, 2010.

Liu S., Chan Y.K., Leung C.Y., Chan K.K.L., Tam K.F., Luk M.H.M., Lo S.S.T., Fong D.Y.T., Cheung A.N.Y., Lin Z.Q. and Ngan H.Y.S., Prevalence and Risk Factors of Human Papillomavirus (HPV) Infection in Southern Chinese Women – A Population-Based Study, PLoS One. 2011, 6(5): e19244-.

Mak C.Y., Siu K.Y., Wong G.W., Ngan H.Y.S., Wong E.S.Y. and Cheung A.N.Y., Downregulation of ASPP1 in gestational trophoblastic disease: correlation with hypermethylation, apoptotic activity and clinical outcome., Modern pathology. 2011, 24: 522-532.

Ngan H.Y.S., Garland S.M., Bhatla N., Pagliusi S.R., Chan K.K.L., Cheung A.N.Y., Chu T.Y., Domingo E.J., Qiao Y.L., Park J.S., Tay E.H. and Supakarapongkul W., Asia oceania guidelines for the implementation of programs for cervical cancer prevention and control, J Cancer Epidemiol, 2011;2011:794861, 2011 Apr 13. 2011.

Siu K.Y., Wong E.S.Y., Chan H.Y., Kong S.H., Woo N.W., Tam K.F., Ngan H.Y.S., Chan Q.K.Y., Chan D.C., Chan Y.K. and Cheung A.N.Y., Differential expression and phosphorylation of Pak1 and Pak2 in ovarian cancer: effects on prognosis and cell invasion, International Journal of Cancer. 2010.

Siu K.Y., Chan H.Y., Kong S.H., Wong E.S.Y., Wong G.W., Ngan H.Y.S., Tam K.F., Tsao G.S.W. and Cheung A.N.Y., p21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients., Proceedings of the National Academy of Sciences of the United States of America . 2010, 107: 18622-18627.

Siu K.Y., Chan H.Y., Kong S.H., Wong S.Y., Wong G.W., Ngan H.Y.S., Tam K.F., Zhang H., Li Z., Chan Q.K.Y., Tsao G.S.W., Strömblad S. and Cheung A.N.Y., p21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients, PNAS. 2010, 107(43): 18622-18627.

Tam K.F., Cheung A.N.Y., Szeto E. and Ngan H.Y.S., Atypical glandular cells diagnosed during pregnancy and the postpartum period: a retrospective analysis, Eur J Obstet Gynecol Reprod Biol, Jan 10. 2011, 155(2): 213-6.

Wong G.W., Lo C.K., Szeto E.F. and Cheung A.N.Y., Efficacy of Abbott RealTime High Risk HPV test in evaluation of atypical squamous cells of undetermined significance from an Asian screening population., Journal of Clinical Virology. 2011, 51: 136-138.

Zhang H., Siu K.Y., Jiang L., Mak C.Y., Ngan H.Y.S., Wong G.W. and Cheung A.N.Y., Overexpressed PAK4 promotes proliferation, migration and invasion of choriocarcinoma., Carcinogenesis. 2011, 32: 765-771.

Researcher : Cheung CH

List of Research Outputs

Lee K.W., Castilho A.G., Cheung C.H., Tang K.H., Ma S.K.Y. and Ng I.O.L., CD24+ liver tumor initiating cells drive self-renewal and tumor initiation through Stat3- mediated Nanog regulation, AACR 102nd Annual meddting 2011.

Lee K.W., Castilho A.G., Cheung C.H., Tang K.H., Ma S.K.Y. and Ng I.O.L., Lupeol targets liver tumor initiating cells through PTEN modulation, Hepatology. 2011, 53: 160-70.

Researcher : Cheung YN

Project Title:	Examination of eIF4E level in human breast cancers and study the role of eIF4E in regulating translation of various splice variants of breast cancer genes
Investigator(s):	Cheung YN, Khoo US, Chan YK
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2010

Project Title:	AACR 101st Annual Meeting eIF4E in human breast cancer and its role in regulating translation of splice variants of breast cancer genes
Investigator(s):	Cheung YN
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Grants for Teaching Staff
Start Date:	04/2010

List of Research Outputs

Chen J., Gomes A.R., Monteiro L.J., Wong S.Y., Wu L.H., Ng T.T., Karadedou C.T., Millour J., Ip Y.C., Cheung Y.N., Sunters A., Chan Y.K., Lam E.W. and Khoo U.S., Constitutively nuclear FOXO3a localization predicts poor survival and promotes Akt phosphorylation in breast cancer, PLoS One. 2010, 5(8): e12293.

Khoo U.S., Zhang L., Cheung Y.N., Chan Y.K., Ip Y.C., Wong S.U. and Tsang W.H., Splice variant profiling of tamoxifen sensitive and resistance breast cancer, 27th HUGO-IABCR Congress 2010, Singapore. 2010.

Researcher : Ching CYJ

List of Research Outputs

Chan Y.K., Xu M.S., Ching C.Y.J., So T.M., Lai S.T., Chu C.M., Yam L.Y., Wong A.T., Chung P.H., Chan V.S.F., Lin C.L., Sham P.C., Leung G.M., Peiris J.S.M. and Khoo U.S., CD209 (DC-SIGN) -336A>G promoter polymorphism and severe acute respiratory syndrome in Hong Kong Chinese, Hum Immunol. 2010, 71(7): 702-7.

Researcher : Ching DCK

List of Research Outputs

Lee H.H.C., Mak C.M., Lam C.W., Yuen L.Y.P., Chan A.O.K., Shek C.C., Siu T.S., Lai C.K., Ching D.C.K., Siu C.W.K., Chen S.P.L., Law C.Y., Tai M.H.L., Tam S. and Chan A.Y.W., Analysis of inborn errors of metabolism: disease spectrum for expanded newborn screening in Hong Kong, Chinese Medical Journal (English Edition). 2011, 124(7): 983-9.

Researcher : Ching JCY

List of Research Outputs

Chan Y.K., Xu M., Ching J.C.Y., Chan V.S.F., Ip Y.C., Yam L., Chu C.M., Lai S.T., So K.M., Wong T.Y., Chung P.H., Tam P., Yip S.P., Sham P.C., Lin C., Leung G.M., Peiris J.S.M. and Khoo U.S., Association of a single nucleotide polymorphism in the CD209 (DC-SIGN) promoter with SARS severity, Hong Kong Med J. 2010, 16(5 Suppl 4): 37-42.

Khoo U.S., Ching J.C.Y., Chan Y.K., Xu M., So K.M., Lai S.T., Chu C.M., Yam L., Wong T.Y., Chung P.H., Chan V.S.F., Tam P.K.H., Yip S.P., Lin C.L., Sham P.C., Leung G.M. and Peiris J.S.M., The CD209 (DC-SIGN) -336A>G and MxA -123C>A promoter polymorphisms in Severe Acute Respiratory Syndrome Coronavirus infection in Hong Kong Chinese, Health Research Symposium 2010: “Improving health and recognising excellence, Hong Kong. 2010.

Researcher : Ching YP

Project Title:	Roles of p21-activated protein kinase (Pak) 1 in the pathogenesis of liver cancer
Investigator(s):	Ching YP, Ng IOL, Jin D, Yau TO
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2006

Project Title:	The roles of CDK5 activator binding protein, LZAP, in the pathogenesis of neurodegenerative disease
Investigator(s):	Ching YP
Department:	Anatomy
Source(s) of Funding:	Travel Grants for NSFC/RGC JRS
Start Date:	12/2007

Project Title:	Functional characterization of a putative tumour suppressor, AMP-activated protein kinase, in liver cancer
Investigator(s):	Ching YP, Jin D, Ng IOL
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2008

Project Title:	The roles of CDK5 activator binding protein, LZAP, in the pathogenesis of neurodegenerative disease
Investigator(s):	Ching YP, Jin D
Department:	Anatomy
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2009

Project Title:	Characterisation of the role of p21-activated protein kinase 4 in liver cancer
Investigator(s):	Ching YP
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2009
Completion Date:	03/2011

Project Title:	Hepatitis B virus promotes hepatocarcinogenesis by activation of Pak1
Investigator(s):	Ching YP, Jin D
Department:	Anatomy
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2010

Project Title:	Functional characterisation of a novel centrosomal protein, TAX1BP2, in liver cancer development
Investigator(s):	Ching YP
Department:	Anatomy
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2010

Project Title:	Characterisation of the roles of LKB1 in liver cancer formation
Investigator(s):	Ching YP
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2010

Project Title:	BIT's 1st World Congress of Virus and Infections 2010 The role of HBx oncoprotein in HCC metastasis
Investigator(s):	Ching YP
Department:	Anatomy
Source(s) of Funding:	URC/CRCG - Conference Grants for Teaching Staff
Start Date:	07/2010
Completion Date:	08/2010

Project Title:	A study of the roles of an atypical small Rho GTPase, RhoV, in liver cancer
Investigator(s):	Ching YP
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2011

Researcher : Choi WL

Project Title:	The Role of FOXP1 and Its Isoforms in the Pathogenesis of Diffuse Large B-cell Lymphoma
Investigator(s):	Choi WL, Srivastava G
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2009

Project Title:	The Effects of DNA Methylation Signature in t(8;21) Acute Myeloid Leukaemia Cells on Patient Outcome
Investigator(s):	Choi WL
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	09/2010
Completion Date:	08/2011

Project Title:	52nd American Society of Hematology Annual Meeting and Exposition Alternative Splicing Is a Major Mechanism of Gene Regulation In Diffuse Large B Cell Lymphoma
Investigator(s):	Choi WL
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Grants for Teaching Staff
Start Date:	12/2010
Completion Date:	12/2010

List of Research Outputs

Choi W.L., Gesk S., Siebert R. and Fu K., Chronic lymphocytic leukemia/small lymphocytic lymphoma with focal D-type cyclin expression in proliferation centers: a report of four cases, Leukemia Research. 2010, 34: e219-e220.

Choi W.L., Mutations of Cytogenetically Normal Acute Myeloid Leukaemia, Second Asia Pacific Symposium on Advanced Molecular Technologies. 2010.

Choi W.L. and Chan W.C., WHO Classification Of Lymphomas, In: O'Brien S, Vose JM, Kantarjian HM, Management Of Hematologic Malignancies. Cambridge University Press, 2010, 228-256.

Gill H., Choi W.L. and Kwong Y.L., Refractory anemia with ringed sideroblasts: more than meets the eye, Journal of Clinical Oncology. 2010, 28: e654-e655.

Jacobs C.L., Patel A., Jima D., Liu Q., Greenough A., Zhang J., Dunphy C., Richards K., Choi W.L., Srivastava G., Evens A.M., Gordon L.I., Czader M., Rizzieri D.A., Lagoo A.S., Mann K.P., Flowers C.R., Bernal-Mizrachi L., Naresh K., Luftig M., Chadburn A., Hsi E., Thompson M.A., Gill J. and Dave S., Alternative Splicing Is a Major Mechanism of Gene Regulation In Diffuse Large B Cell Lymphoma, The 52nd American Society of Hematology Annual Meeting and Exposition. 2010.

Jima D.D., Zhang J., Jacobs C.J., Richards K.L., Dunphy C.H., Choi W.L., Au W.Y., Srivastava G., Czader M.B., Rizzieri D.A., Lagoo A.S., Lugar P.L., Mann K.P., Flowers C.R., Bernal-Mizrachi L., Naresh K.N., Evens A.M., Gordon L.I., Luftig M.A., Friedman D.R., Weinberg J.B., Thompson M.A., Gill J.I., Liu Q., How T., Grubor V., Gao Y., Patel A., Wu H., Zhu J., Blobe G.C., Lipsky P.E., Chadburn A. and Dave S.S., Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs, Blood. 2010, 116: e118-e127.

Researcher : Chow EYD

List of Research Outputs

So J.C.C., Chan A.Y.Y., Chow E.Y.D., Lin S.Y., Yip S.F., Szeto S.C. and Chan L.C., Haemoglobin Bonn in a Chinese family as a cause of spurious hypoxaemia measured by pulse oximetry, J Clin Pathol. 2010, 63(10): 947-9.

Researcher : Chu KY

List of Research Outputs

Sze M.F., Wong L.T., Chu K.Y., Lee M.F., Yau T.O. and Ng I.O.L., Loss of phosphatase and tensin homolog enhances cell invasion and migration through AKT/Sp-1 transcription factor/matrix metalloproteinase 2 activation in hepatocellular carcinoma and has clinicopathologic significance, In: Keith D. Lindor, Hepatology. 2011, 53 Issue 5: 1558-1569.

Researcher : Chung LP

List of Research Outputs

Chim J.C.S., Wong K.Y., Leung C.Y., Chung L.P., Hui P.K., Chan S.Y. and Yu L., Epigenetic inactivation of the hsa-miR-203 in haematological malignancies, J Cell Mol Med. 2011, [Epub ahead of print].

Wong D.W., Leung L.H., Wong K.M., Tin P.C., Sihoe A.D., Cheng L.C., Au J.S., Chung L.P. and Wong M.P., A novel KIF5B-ALK variant in nonsmall cell lung cancer, Cancer. 2011, 117(12): 2709-18.

Wong K.Y., So J.C.C., Loong F., Chung L.P., Lam W.W.L., Liang R.H.S., Jin D. and Chim J.C.S., Epigenetic inactivation of the miR-124-1 in haematological malignancies, PLoS One. 2011, 22;6(4).

Researcher : Fan NY

List of Research Outputs

Liang L., Wong C.M., Ying Q., Fan N.Y., Huang S., Ding J., Yao J., Yan M., Li J., Yao M., Ng I.O.L. and He X., MicroRNA-125b suppressesed human liver cancer cell proliferation and metastasis by directly targeting oncogene LIN28B2, Hepatology. 2010, 52: 1731-40.

Researcher : Fung KHY

List of Research Outputs

Hui F.F., Chan W.Y., Fung K.H.Y., Yu C.L., Tsao G.S.W., Chan M.C.W. and Nicholls J.M., The regional distribution of different types of influenza receptors in cultured human alveolar epithelial cells and correlation with in vitro infection, Influenza and other respiratory viruses. 2011, 5(S1): 436-437.

Researcher : Ip PPC

List of Research Outputs

HU Y.J., Ip P.P.C., Tam K.F. and Ngan H.Y.S., Ovarian clear cell carcinoma with choriocarcinomatous differentiation: report of a rare and aggressive tumor., Int J Gynecol Pathol. 2010, 29(6): 539-45.

Hu Y., Ip P.P.C., Chan K.K.L., Tam K.F. and Ngan H.Y.S., Ovarian clear cell carcinoma with choriocarcinomatous differentiation: report of a rare and aggressive tumor. , Int J Gynecol Pathol.. 2010, 29(6).

Researcher : Ip YC

Project Title:	Targeting Granulin for Breast Cancer Therapy
Investigator(s):	Ip YC, Khoo US
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2008

List of Research Outputs

Chan Y.K., Xu M., Ching J.C.Y., Chan V.S.F., Ip Y.C., Yam L., Chu C.M., Lai S.T., So K.M., Wong T.Y., Chung P.H., Tam P., Yip S.P., Sham P.C., Lin C., Leung G.M., Peiris J.S.M. and Khoo U.S., Association of a single nucleotide polymorphism in the CD209 (DC-SIGN) promoter with SARS severity, Hong Kong Med J. 2010, 16(5 Suppl 4): 37-42.

Chen J., Gomes A.R., Monteiro L.J., Wong S.Y., Wu L.H., Ng T.T., Karadedou C.T., Millour J., Ip Y.C., Cheung Y.N., Sunters A., Chan Y.K., Lam E.W. and Khoo U.S., Constitutively nuclear FOXO3a localization predicts poor survival and promotes Akt phosphorylation in breast cancer, PLoS One. 2010, 5(8): e12293.

Khoo U.S., Zhang L., Cheung Y.N., Chan Y.K., Ip Y.C., Wong S.U. and Tsang W.H., Splice variant profiling of tamoxifen sensitive and resistance breast cancer, 27th HUGO-IABCR Congress 2010, Singapore. 2010.

Researcher : Jiang L

List of Research Outputs

Jiang L., Siu K.Y., Wong G.W., Tam K.F., Ngan H.Y.S., Wong S.Y., Chan H.Y. and Cheung A.N.Y., Overexpression of proto-oncogene FBI-1 activates membrane type 1-matrix metalloproteinase in association with adverse outcome in ovarian cancers., Molecular cancer. 2010, 9: 318.

Zhang H., Siu K.Y., Jiang L., Mak C.Y., Ngan H.Y.S., Wong G.W. and Cheung A.N.Y., Overexpressed PAK4 promotes proliferation, migration and invasion of choriocarcinoma., Carcinogenesis. 2011, 32: 765-771.

Researcher : Kan J

Project Title:	The possible role and function of a histone H3K4 demethylase, JARID1B in defining colorectal cancer stem cells
Investigator(s):	Kan J, Leung SY
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	02/2011

Researcher : Khoo US

Project Title:	Association of the pro-inflammatory and anti-inflammatory cytokine gene polymorphism to breast cancer susceptibility
Investigator(s):	Khoo US, Cheung ANY, Chan YK
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Project Title:	Infectious Diseases and Global Health: Genetic approach to the identification of host susceptibility factors and pathogen virulence determinants. Genetics of coronaviruses-associated acute respiratory disease
Investigator(s):	Khoo US
Department:	Pathology
Source(s) of Funding:	CGDN NCE Large Scale Collaborative Research Grant
Start Date:	02/2005

Project Title:	Promoter polymorphisms of L-SIGN in relation to host genetic susceptibility to SARS.
Investigator(s):	Khoo US, Chan YK
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2006

Project Title:	Splice variant expression in relation to Estrogen Receptor gene expression in Chinese breast cancer
Investigator(s):	Khoo US, Chan YK, Kwong A
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2007

Project Title:	Ubiquitination of Estrogen Receptor-alpha (ESR1) isoforms
Investigator(s):	Khoo US, Chan YK
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2007

Project Title:	The role of FOXO transcription factors in the development of hormone refractory breast cancer
Investigator(s):	Khoo US, Chan YK, Ip YC
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2009

Project Title:	A pre-neoplastic marker for basal-like breast cancer
Investigator(s):	Khoo US, Chan YK
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2010

Project Title:	HER2 FISH test to assess eligibility for transtuzumab (herceptin) in breast cancer patients applying for assistance from Samaritan Fund for treatment
Investigator(s):	Khoo US, Au GKH, Leung TW, Luk MY, Yau TK
Department:	Pathology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	07/2010

Project Title:	27th HUGO-IABCR 2010 congress on Genomics, Biology and Breast Cancer Treatment Splice variant profiling of tamoxifen sensitive and resistance breast cancer
Investigator(s):	Khoo US
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Grants for Teaching Staff
Start Date:	10/2010
Completion Date:	10/2010

Project Title:	Characterization of candidate microRNAs associated with Tamoxifen resistance in breast cancer
Investigator(s):	Khoo US, Cheung YN
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	03/2011

List of Research Outputs

Cai Q., Wen W., Qu S., Li G., Egan K.M., Chen K., Deming S.L., Shen H., Shen C.Y., Gammon M.D., Blot W.J., Matsuo K., Haiman C.A., Khoo U.S., Iwasaki M., Santella R.M., Zhang L., Fair A.M., Hu Z., Wu P.E., Signorello L.B., Titus-Ernstoff L., Tajima K., Henderson B.E., Chan Y.K., Kasuga Y., Newcomb P.A., Zheng H., Cui Y., Wang F., Shieh Y.L., Iwata H., Le Marchand L., Chan S.Y., Shrubsole M.J., Trentham-Dietz A., Tsugane S., Garcia-Barcelo M.M., Long J., Li C., Shi J., Huang B., Xiang Y.B., Gao Y.T., Lu W., Shu X.O. and Zheng W., Replication and functional genomic analyses of the breast cancer susceptibility locus at 6q25.1 generalize its importance in women of chinese, Japanese, and European ancestry, Cancer Res. 2011, 71(4): 1344-55.

Chan Y.K., Xu M., Ching J.C.Y., Chan V.S.F., Ip Y.C., Yam L., Chu C.M., Lai S.T., So K.M., Wong T.Y., Chung P.H., Tam P., Yip S.P., Sham P.C., Lin C., Leung G.M., Peiris J.S.M. and Khoo U.S., Association of a single nucleotide polymorphism in the CD209 (DC-SIGN) promoter with SARS severity, Hong Kong Med J. 2010, 16(5 Suppl 4): 37-42.

Chan Y.K., Xu M.S., Ching C.Y.J., So T.M., Lai S.T., Chu C.M., Yam L.Y., Wong A.T., Chung P.H., Chan V.S.F., Lin C.L., Sham P.C., Leung G.M., Peiris J.S.M. and Khoo U.S., CD209 (DC-SIGN) -336A>G promoter polymorphism and severe acute respiratory syndrome in Hong Kong Chinese, Hum Immunol. 2010, 71(7): 702-7.

Chen J., Gomes A.R., Monteiro L.J., Wong S.Y., Wu L.H., Ng T.T., Karadedou C.T., Millour J., Ip Y.C., Cheung Y.N., Sunters A., Chan Y.K., Lam E.W. and Khoo U.S., Constitutively nuclear FOXO3a localization predicts poor survival and promotes Akt phosphorylation in breast cancer, PLoS One. 2010, 5(8): e12293.

Khoo U.S., "The Interpretation and Reporting of ER and PR in Breast Carcinomas"; "How to Interpret HER2/neu in Breast Carcinomas including Issues and Updates" & "Molecular Classification and Genetic Testing for Breast Cancers", 60th Annual Convention of the Philippine Society of Pathologists, Manila. 2011.

Khoo U.S., Zhang L., Cheung Y.N., Chan Y.K., Ip Y.C., Wong S.U. and Tsang W.H., Splice variant profiling of tamoxifen sensitive and resistance breast cancer, 27th HUGO-IABCR Congress 2010, Singapore. 2010.

Khoo U.S., Ching J.C.Y., Chan Y.K., Xu M., So K.M., Lai S.T., Chu C.M., Yam L., Wong T.Y., Chung P.H., Chan V.S.F., Tam P.K.H., Yip S.P., Lin C.L., Sham P.C., Leung G.M. and Peiris J.S.M., The CD209 (DC-SIGN) -336A>G and MxA -123C>A promoter polymorphisms in Severe Acute Respiratory Syndrome Coronavirus infection in Hong Kong Chinese, Health Research Symposium 2010: “Improving health and recognising excellence, Hong Kong. 2010.

Ng M.H.L., Cheng S.H., Lau K.M., Leung G.M., Khoo U.S., Zee B.C.W. and Sung J.J.Y., Immunogenetics in SARS: A case-control study, Hong Kong Medical Journal. 2010, 16 (Suppl 4): S29-S33.

Yuen H.F., Chan Y.K., Grills C., McCrudden C.M., Gunasekharan V., Shi Z., Wong S.Y., Lappin T.R., Chan K.W., Fennell D.A., Khoo U.S., Johnston P.G. and El-Tanani M., Polyomavirus enhancer activator 3 protein promotes breast cancer metastatic progression through Snail-induced epithelial-mesenchymal transition, J Pathol. 2011, 224(1): 78-89.

Yuen H.F., McCrudden C.M., Chan K.K., Chan Y.P., Wong M.L.Y., Chan Y.K., Khoo U.S., Law S., Srivastava G., Lappin T.R., Chan K.W. and El-Tanani M., The role of pea3 group transcription factors in esophageal squamous cell carcinoma, Am J Pathol. 2011, 179 (2): 992-1003.

Researcher : Ko FCF

Project Title:	Characterization of PKA pathway in hepatocellular carcinoma (HCC)
Investigator(s):	Ko FCF, Yam JWP
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2010
Completion Date:	06/2011

List of Research Outputs

Chan J., Ko F.C.F., Ng I.O.L. and Yam J.W.P., Integrin-linked kinase overexpression and its oncogenic role in promoting tumorigenicity of hepatocellular carcinoma, PLoS ONE. 2011, 6(2): e16984.

Ko F.C.F., Chan L.K., Tung K.K., Scott S.W., Ng I.O.L. and Yam J.W.P., Akt phosphorylation of deleted in liver cancer 1 abrogates its suppression of liver cancer tumorigenesis and metastasis., Gastroenterology. Elsevier Inc., 2010, 139: 1397-1407.e6.

Ko F.C.F., Ng I.O.L. and Yam J.W.P., DLC1 (deleted in liver cancer 1), Atlas of Genetics and Cytogenetics in Oncology and Haematology. 2010.

Ko F.C.F., Chan L.K., Ng I.O.L. and Yam J.W.P., PKA Phosphorylation of Deleted in Liver Cancer 1 (DLC1) at serine-549 modulates its inhibitory activity in liver cancer tumourigenesis, The 3rd JCA-AACR Special Joint Conference, Chiba, Japan. 2011.

Wong C.M., Wong C.C.L., Ng Y.L., Au L.K., Ko F.C.F. and Ng I.O.L., Transcriptional repressive H3K9 and H3K27 methylations contribute to DNMT1-mediated DNA methylation recovery, American Association for Cancer Research (AACR) 102 st Annual meeting 2011.

Researcher : Ko KH

List of Research Outputs

Yao H., Ng S.M., Huo L.F., Chow B.K.C., Shen Z., Ko K.H., Li M., Lu L., Bian X.W., Kung H.F. and Lin M.C., Effective melanoma immunotherapy with interleukin-2 delivered by a novel polymeric nanoparticle, Molecular Cancer Therapeutics. 2011, 10: 1082-1092.

Researcher : Kong SH

List of Research Outputs

Siu K.Y., Wong E.S.Y., Chan H.Y., Kong S.H., Woo N.W., Tam K.F., Ngan H.Y.S., Chan Q.K.Y., Chan D.C., Chan Y.K. and Cheung A.N.Y., Differential expression and phosphorylation of Pak1 and Pak2 in ovarian cancer: effects on prognosis and cell invasion, International Journal of Cancer. 2010.

Siu K.Y., Chan H.Y., Kong S.H., Wong E.S.Y., Wong G.W., Ngan H.Y.S., Tam K.F., Tsao G.S.W. and Cheung A.N.Y., p21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients., Proceedings of the National Academy of Sciences of the United States of America . 2010, 107: 18622-18627.

Siu K.Y., Chan H.Y., Kong S.H., Wong S.Y., Wong G.W., Ngan H.Y.S., Tam K.F., Zhang H., Li Z., Chan Q.K.Y., Tsao G.S.W., Strömblad S. and Cheung A.N.Y., p21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients, PNAS. 2010, 107(43): 18622-18627.

Researcher : Kong SH

List of Research Outputs

Researcher : Kwan PS

List of Research Outputs

Ma S.K.Y., Kwan P.S., Chan Y.P., Fu L., Tang K.H., Tong M., Chan K.W. and Guan X., RNA-Seq identifies protein tyrosine kinase 6 (PTK6) as a candidate tumor-suppressor gene in esophageal squamous cell carcinoma , American Association for Cancer Research - Annual Meeting 2011.

Ma S.K.Y., Chan Y.P., Kwan P.S., Lee K.W., Yan M., Tang K.H., Ling M.T., Vielkind J.R., Guan X. and Chan K.W., microRNA-616 induces androgen-independent growth of prostate cancer cells by suppressing expression of tissue factor pathway inhibitor TFPI-2, Cancer Research. 2011, 71: 583-92.

Tang K.H., Ma S.K.Y., Kwan P.S., Chan Y.P., Lee K.W., Ng I.O.L., Guan X. and Chan K.W., CD133+ liver tumor-initiating cells promote tumor growth, angiogenesis and self-renewal through activation of the neurotensin / interleukin-8 signaling cascade, American Association for Cancer Reseach - Annual Meeting 2011.

Researcher : Lam AKY

List of Research Outputs

Tong D.K.H., Law S.Y.K., Kwong D.L.W., Chan K.W., Lam A.K.Y. and Wong K.H., Histological regression of squamous esophageal carcinoma assessed by percentage of residual viable cells after neoadjuvant chemoradiation is an important prognostic factor, Ann Surg Oncol. 2010, 17(8): 2184-92.

Researcher : Lam CCK

List of Research Outputs

Ho S.L., Loong F., Lam C.C.K., Anthony M. and Kwong Y.L., F-18 Fluorodeoxyglucose non-avid hepatosplenic T cell lymphoma: a diagnostic pitfall., Ann Hematol.. 2011.

Ma L., Zheng L., Sham M.H., Lam C.C.K., Zwahlen R.A. and Cheung L.K., Effect of platelet rich plasma on a rabbit model of nicotine compromised bone healing , J Oral Maxillofac Surg. 2010, 69: 28-35.

So J.C.C., Leung R.Y.Y., Yip S.F., Chan S.Y., Lam C.C.K., Chan G.C.F., Chim S. and Chan L.C., Common association of haemolytic uraemic syndrome with invasive Streptococcus pneumoniae infection in five Chinese paediatric patients, Hong Kong Med J. 2011, 17(3): 237-41.

Researcher : Lam CW

Project Title:	Whole genome scan of genetic susceptibility for hepatitis B carries
Investigator(s):	Lam CW
Department:	Pathology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	04/2006

Project Title:	Therapeutic antibodies against basal cell carcinomas of the skin
Investigator(s):	Lam CW
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2009

Project Title:	Molecular basis of autism spectrum disorders in Chinese
Investigator(s):	Lam CW
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2010

Project Title:	Clinical Biomonitoring of Environmental Chemicals
Investigator(s):	Lam CW
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2011

List of Research Outputs

Lam C.W., A new mechanism for stone formation, Departmental Seminar, Clinical Biochemistry, Queen Mary Hospital, December 9, 2010. 2010.

Lam C.W., Acid Base, RCPA AACB Chemical Pathology Course, April 4-8, 2011, Adelaide, South Australia. 2011.

Lam C.W., Associate Editor, Clinica Chimica Acta. 2010.

Lam C.W., Cancer screening - biochemical and molecular markers, Hong Kong Academy of Medicine, November 13, 2010. 2010.

Lam C.W. and Lau K.C., Candidate Screening through High-Density SNP Array, Gene Discovery for Disease Models. 2011, 195-214.

Lam C.W., Lau K.C., Mak C.M., Tsang M.W. and Chan A.Y.W., Circulating fluorocytes at the first attack of acute intermittent porphyria: a missing link in the pathogenesis, Clinica Chimica Acta. 2011, 412(1-2): 208-12.

Lam C.W., Editorial Board member, Journal of Chinese Clinical Medicine. 2010.

Lam C.W., Genetic Testing and Personalized Medicine, 9th Asia Pacific Conference on Human Genetics, Nov 30 - Dec 3, 2010, Hong Kong. 2010.

Lam C.W., Genetic testing and personalised medicine, Genetics and Genomics, Global and Local, Hospital Authority Joint Commissioned Training, Coordinating Committee in Pathology and Central Committee on Genetic Services, November 10, 2010. 2010.

Lam C.W., Inherited metabolic diseases and personalized medicine (Theme: Laboratory Diagnosis of Inherited Metabolic Diseases), The 12th Asian-Pacific Congress of Clinical Biochemistry, Korean Society of Clinical Chemistry, October 3-7, 2010, Seoul, Korea. 2010.

Lam C.W., Microarrays for Personalized Genomic Medicine, International Forum on Laboratory Medicine 2011, June 28 - July 1, 2011, Wenzhou Medical College, Wenzhou, China. 2011.

Lam C.W., Lau K.C. and Tong S.F., Microarrays for personalized genomic medicine, Advances in Clinical Chemistry. 2010, 52: 1-18.

Lam C.W., Molecular Theranostics, 2nd Asia Pacific Symposium on Advanced Molecular Technologies, Hong Kong Society for Molecular Diagnostic Sciences Ltd., August 15, 2010. 2010.

Lam C.W., Neonatal Metabolic Screening in Hong Kong - how far should we go, Private Practicing Paediatrician Study Group, January 4, 2011, Eaton Hotel, Hong Kong. 2011.

Lam J.K., Lam C.W., Kung A.W.C., Tan K.C.B., Lau K.S. and Lam K.S.L., A man with hypophosphataemia, BMJ. 2011, 342:d773.

Lam J.K.Y., Lam C.W., Kung A.W.C., Tan K.C.B., Lau K.S. and Lam K.S.L., A man with hypophosphataemia, British Medical Journal. 2011, 342: d773.

Lau K.C., Lam C.W., Law C.Y., Lai S.T., Tsang T.Y., To W.K., Leung K.F., Mak C.M., Poon D.W.T., Chan P.K. and Chan A.Y.W., Non-invasive screening of HLA-DPA1 and HLA-DPB1 alleles for persistent hepatitis B virus infection: susceptibility for vertical transmission and toward a personalized approach for vaccination and treatment, Clinica Chimica Acta. 2011, 412(11-12): 952-7.

Lee H.H.C., Mak C.M., Lam C.W., Yuen L.Y.P., Chan A.O.K., Shek C.C., Siu T.S., Lai C.K., Ching D.C.K., Siu C.W.K., Chen S.P.L., Law C.Y., Tai M.H.L., Tam S. and Chan A.Y.W., Analysis of inborn errors of metabolism: disease spectrum for expanded newborn screening in Hong Kong, Chinese Medical Journal (English Edition). 2011, 124(7): 983-9.

Lee H.H.C., Lai C.K., Siu T.S., Chan K.Y., Chan A.Y.W., Tam S., Mak C.M. and Lam C.W., Role of Postmortem Genetic Testing Demonstrated in a Case of Glutaric Aciduria Type II, Diagnostic Molecular Pathology . 2010, 19(3): 184-6.

Leung T.W., Yip S.F., Lam C.W., Chan T.L., Lam W.W., Siu D.Y., Fan Y.H., Chan N.P., Liu H.S., Chan L.C. and Wong K.S., Genetic predisposition of white matter infarction with protein S deficiency and R355C mutation, Neurology. 2010, 75(24): 2185-9.

Mak C.M., Sheng B., Lee H.H.C., Lau K.K., Chan W.T., Lam C.W. and Chan A.Y.W., Young-onset parkinsonism in a Hong Kong Chinese man with adult-onset Hallervorden-Spatz syndrome, International Journal of Neuroscience. 2011, 121(4): 224-7.

Sass J.O., Gunduz A., Araujo Rodrigues Funayama C., Korkmaz B., Dantas Pinto K.G., Tuysuz B., Yanasse Dos Santos L., Taskiran E., de Fatima Turcato M., Lam C.W., Reiss J., Walter M., Yalcinkaya C. and Camelo Junior J.S., Functional deficiencies of sulfite oxidase: Differential diagnoses in neonates presenting with intractable seizures and cystic encephalomalacia, Brain & Development. 2010, 32(7): 544-9.

Siu C.W.K., Ma R.C., Lam C.W., Mak C.M., Yuen L.Y.P., Lo F.M., Chan K.W., Lam S.F., Ling S.C., Tong S.F., So W.Y., Chow C.C., Tang M.H., Tam W.H. and Chan A.Y.W., Molecular basis of von Hippel-Lindau syndrome in Chinese patients, Chinese Medical Journal (English Version). 2011, 124(2): 237-41.

Wong W.C., Lam C.W., Tong S.F. and Tong C.T., Persistent hypocalcaemia in a Chinese girl due to a novel de-novo activating mutation of the calcium-sensing receptor gene, Hong Kong Medical Journal. 2011, 17(2): 157-60.

Yeung W.L., Wong V.C.N., Chan K.Y., Hui J., Fung C.W., Yau F.T., Ko C.H., Lam C.W., Mak C.M., Siu S. and Low L.C.K., Expanding Phenotype and Clinical Analysis of Tyrosine Hydroxylase Deficiency, J Child Neurol 2011 26(2): 179-187. 2011.

Yeung W.L., Wong V.C., Chan K.Y., Hui J., Fung C.W., Yau E., Ko C.H., Lam C.W., Mak C.M., Siu S. and Low L., Expanding phenotype and clinical analysis of tyrosine hydroxylase deficiency, Journal of Child Neurology. 2011, 26(2): 179-87.

Researcher : Lam QLK

List of Research Outputs

Lam Q.L.K., Wang S., Ko O.K., Kincade P.W. and Lu L., Leptin signaling maintains B-cell homeostasis via induction of Bcl-2 and Cyclin D1, Proc Natl Acad Sci U S A. 2010, 107(31): 13812-7.

Researcher : Lau KC

List of Research Outputs

Lam C.W. and Lau K.C., Candidate Screening through High-Density SNP Array, Gene Discovery for Disease Models. 2011, 195-214.

Lam C.W., Lau K.C., Mak C.M., Tsang M.W. and Chan A.Y.W., Circulating fluorocytes at the first attack of acute intermittent porphyria: a missing link in the pathogenesis, Clinica Chimica Acta. 2011, 412(1-2): 208-12.

Lam C.W., Lau K.C. and Tong S.F., Microarrays for personalized genomic medicine, Advances in Clinical Chemistry. 2010, 52: 1-18.

Lau K.C., Lam C.W., Law C.Y., Lai S.T., Tsang T.Y., To W.K., Leung K.F., Mak C.M., Poon D.W.T., Chan P.K. and Chan A.Y.W., Non-invasive screening of HLA-DPA1 and HLA-DPB1 alleles for persistent hepatitis B virus infection: susceptibility for vertical transmission and toward a personalized approach for vaccination and treatment, Clinica Chimica Acta. 2011, 412(11-12): 952-7.

Researcher : Lau WH

List of Research Outputs

Gill H., Chan T., Lau W.H., Loong F., Hwang Y.Y., Wong C.S. and Khong P.L., Two tales of two lymphomas, Journal of Clinical Oncology. 2011, 29(20): e610-612.

Researcher : Law CY

List of Research Outputs

Lau K.C., Lam C.W., Law C.Y., Lai S.T., Tsang T.Y., To W.K., Leung K.F., Mak C.M., Poon D.W.T., Chan P.K. and Chan A.Y.W., Non-invasive screening of HLA-DPA1 and HLA-DPB1 alleles for persistent hepatitis B virus infection: susceptibility for vertical transmission and toward a personalized approach for vaccination and treatment, Clinica Chimica Acta. 2011, 412(11-12): 952-7.

Lee H.H.C., Mak C.M., Lam C.W., Yuen L.Y.P., Chan A.O.K., Shek C.C., Siu T.S., Lai C.K., Ching D.C.K., Siu C.W.K., Chen S.P.L., Law C.Y., Tai M.H.L., Tam S. and Chan A.Y.W., Analysis of inborn errors of metabolism: disease spectrum for expanded newborn screening in Hong Kong, Chinese Medical Journal (English Edition). 2011, 124(7): 983-9.

Researcher : Lee HHC

List of Research Outputs

Lee H.H.C., Mak C.M., Lam C.W., Yuen L.Y.P., Chan A.O.K., Shek C.C., Siu T.S., Lai C.K., Ching D.C.K., Siu C.W.K., Chen S.P.L., Law C.Y., Tai M.H.L., Tam S. and Chan A.Y.W., Analysis of inborn errors of metabolism: disease spectrum for expanded newborn screening in Hong Kong, Chinese Medical Journal (English Edition). 2011, 124(7): 983-9.

Lee H.H.C., Lai C.K., Siu T.S., Chan K.Y., Chan A.Y.W., Tam S., Mak C.M. and Lam C.W., Role of Postmortem Genetic Testing Demonstrated in a Case of Glutaric Aciduria Type II, Diagnostic Molecular Pathology . 2010, 19(3): 184-6.

Mak C.M., Sheng B., Lee H.H.C., Lau K.K., Chan W.T., Lam C.W. and Chan A.Y.W., Young-onset parkinsonism in a Hong Kong Chinese man with adult-onset Hallervorden-Spatz syndrome, International Journal of Neuroscience. 2011, 121(4): 224-7.

Researcher : Lee KW

Project Title:	The significance of nucleophosmin phosphorylation (Threonine 234) in HCC metastasis
Investigator(s):	Lee KW, Ng IOL
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2010

Project Title:	Clinical relevance and functional characterization of NEDD9 in hepatocellular carcinoma
Investigator(s):	Lee KW, Ng IOL
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2011

Project Title:	AACR 102nd Annual meeting 2011 CD24+ liver tumor-initiating cells drives self-renewal and tumor initiation through Stat3-mediated Nanog regulation
Investigator(s):	Lee KW
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Grants for Teaching Staff
Start Date:	04/2011
Completion Date:	04/2011

List of Research Outputs

Lee K.W., Castilho A.G., Cheung C.H., Tang K.H., Ma S.K.Y. and Ng I.O.L., CD24+ liver tumor initiating cells drive self-renewal and tumor initiation through Stat3- mediated Nanog regulation, AACR 102nd Annual meddting 2011.

Lee K.W., Castilho A.G., Cheung C.H., Tang K.H., Ma S.K.Y. and Ng I.O.L., Lupeol targets liver tumor initiating cells through PTEN modulation, Hepatology. 2011, 53: 160-70.

Luk S.U., Lee K.W., Liu J.I., Lee D.T.W., Chiu Y.T., Ma S.K.Y., Ng I.O.L., Wong Y.C., Chan F.L. and Ling M.T., Chemopreventive effect of PSP through targeting of prostate cancer stem cell-like population, PLoS One. 2011, 6: e19804.

Ma S.K.Y., Tang K.H., Chan Y.P., Lee K.W., Kwan P.S., Castilho A.G., Ng I.O.L., Man K., Wong N., To K.F., Zheng B., Lai P.B.S., Lo C.M., Chan K.W. and Guan X.Y., miR-130b promotes CD133(+) liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1, Cell Stem Cell. 2010, 7(6): 694-707.

Ma S.K.Y., Chan Y.P., Kwan P.S., Lee K.W., Yan M., Tang K.H., Ling M.T., Vielkind J.R., Guan X. and Chan K.W., microRNA-616 induces androgen-independent growth of prostate cancer cells by suppressing expression of tissue factor pathway inhibitor TFPI-2, Cancer Research. 2011, 71: 583-92.

Ng K.T.P., Lee K.W., Cheng Q., Wo Y.H., Sun K.W., Guo D., Lim Z.X.H., Lo C.M., Poon R.T.P., Fan S.T. and Man K., Suppression of tumorigenesis and metastasis of hepatocellular carcinoma by shRNA interference targeting on homeoprotein Six1, International Journal of Cancer. 2010, 127(4): 859-872.

Tang K.H., Ma S.K.Y., Kwan P.S., Chan Y.P., Lee K.W., Ng I.O.L., Guan X. and Chan K.W., CD133+ liver tumor-initiating cells promote tumor growth, angiogenesis and self-renewal through activation of the neurotensin / interleukin-8 signaling cascade, American Association for Cancer Reseach - Annual Meeting 2011.

Researcher : Lee MF

List of Research Outputs

Gao P., Wong C.C.L., Tung K.K., Lee M.F., Wong C.M. and Ng I.O.L., Deregulation of microRNA expression occurs early and accumulates in early stages of HBV-associated multistep hepatocarcinogenesis., Journal of Hepatology. Elsevier B.V., 2011, 54: 1177-1184.

Mak W.Y.G., Chan M.L., Leong V.Y.L., Lee M.F., Yau T.O., Ng I.O.L. and Ching Y.P., Overexpression of a novel activator of PAK4, the CDK5 kinase-associated protein CDK5RAP3, promotes hepatocellular carcinoma metastasis, Cancer Research. 2011, 71: 2949-58.

Sze M.F., Wong L.T., Chu K.Y., Lee M.F., Yau T.O. and Ng I.O.L., Loss of phosphatase and tensin homolog enhances cell invasion and migration through AKT/Sp-1 transcription factor/matrix metalloproteinase 2 activation in hepatocellular carcinoma and has clinicopathologic significance, In: Keith D. Lindor, Hepatology. 2011, 53 Issue 5: 1558-1569.

Wong C.C.L., Wong C.M., Tung K.K., Au L.K., Lee M.F., Poon R.T.P., Man K. and Ng I.O.L., The microRNA miR-139 suppresses metastasis and progression of hepatocellular carcinoma by down-regulating Rho-kinase 2, Gastroenterology. 2011, 140(1): 322-331.

Wong C.M., Wong C.C.L., Tung K.K., Au L.K., Lee M.F., Man K. and Ng I.O.L., MiR-139 suppresses metastasis and progression of hepatocellular carcinoma through regulation of Rho-Kinase 2 (ROCK2), International Liver Cancer Association Fourth Annual Conference . Montreal, QC, Canada, 2010.

Researcher : Leung CY

List of Research Outputs

Chim J.C.S., Wong K.Y., Leung C.Y., Chung L.P., Hui P.K., Chan S.Y. and Yu L., Epigenetic inactivation of the hsa-miR-203 in haematological malignancies, J Cell Mol Med. 2011, [Epub ahead of print].

Researcher : Leung KF

List of Research Outputs

Lau K.C., Lam C.W., Law C.Y., Lai S.T., Tsang T.Y., To W.K., Leung K.F., Mak C.M., Poon D.W.T., Chan P.K. and Chan A.Y.W., Non-invasive screening of HLA-DPA1 and HLA-DPB1 alleles for persistent hepatitis B virus infection: susceptibility for vertical transmission and toward a personalized approach for vaccination and treatment, Clinica Chimica Acta. 2011, 412(11-12): 952-7.

Researcher : Leung L.H.

Project Title:	Identification, isolation, expansion and characterization of cancer stem cells in non-small cell lung cancer
Investigator(s):	Leung LH, Chung LP, Wong MP
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	08/2009
Completion Date:	01/2011

List of Research Outputs

Wong W...S..., Leung L...H..., Wong K.M., Tin P...C... and Wong M...P..., A novel KIF5B-ALK fusion gene variant with transforming potentials in non-small cell lung cancer, 102nd American Association for Cancer Research meeting, Orlando, U.S., April 2011 . 2011.

Researcher : Leung LH

Project Title:	Identification, isolation, expansion and characterization of cancer stem cells in non-small cell lung cancer
Investigator(s):	Leung LH, Chung LP, Wong MP
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	08/2009
Completion Date:	01/2011

List of Research Outputs

Leung L.H., Fiscus R.R., Tung J.W., Tin P.C., Cheng L.C., Sihoe A.D.L., Fink L.M., Ma Y. and Wong M.P., Non-small cell lung cancer cells expressing CD44 are enriched for stem cell-like properties, PLoS One. 2010, 5(11): e14062.

Wong D.W., Leung L.H., Wong K.M., Tin P.C., Sihoe A.D., Cheng L.C., Au J.S., Chung L.P. and Wong M.P., A novel KIF5B-ALK variant in nonsmall cell lung cancer, Cancer. 2011, 117(12): 2709-18.

Wong K.M., Leung L.H., Tin P.C. and Wong M.P., Non-small cell lung cancer cells with high aldehyde dehydrogenase 1 activity display cancer stem cell properties and show chemoresistance, 102nd American Association for Cancer Research meeting, Orlando, U.S., 3 April 2011.

Researcher : Leung RYY

List of Research Outputs

Au W.Y., Ngai C.W., Chan W.M., Leung R.Y.Y. and Chan S.C., Hemolysis and methemoglobinemia due to hepatitis E virus infection in patient with G6PD deficiency (Letter to the Editor) , Annals of Hematology. 2011, 90(10): 1237-1238.

So J.C.C., Leung R.Y.Y., Yip S.F., Chan S.Y., Lam C.C.K., Chan G.C.F., Chim S. and Chan L.C., Common association of haemolytic uraemic syndrome with invasive Streptococcus pneumoniae infection in five Chinese paediatric patients, Hong Kong Med J. 2011, 17(3): 237-41.

Researcher : Leung SY

Project Title:	Identification of BRAF mutation in various stages of colorectal carcinogenesis and its relationship with KRAS mutation
Investigator(s):	Leung SY, Yuen ST
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002

Project Title:	Detail study of relationship of BRAF and KRAS mutation with microstatellite instability in colorectal cancer
Investigator(s):	Leung SY, Yuen ST
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Project Title:	Genomic screening for potential tumour suppressors silenced by promoter hypermethylation in gastric adenocarcinomas using cDNA microarray
Investigator(s):	Leung SY, Yuen ST, Chu KM, Fung TWK, Lin MC, Chen X
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2005

Project Title:	Genomics, genetics and clinico-pathological study of gastrointestinal cancers
Investigator(s):	Leung SY
Department:	Pathology
Source(s) of Funding:	Croucher Senior Medical Research Fellowships
Start Date:	07/2007

Project Title:	Research Output Prize (Faculty of Medicine)
Investigator(s):	Leung SY
Department:	Pathology
Source(s) of Funding:	Research Output Prize (in Faculty)
Start Date:	11/2007

Project Title:	Outstanding Researcher Award 2006-2007
Investigator(s):	Leung SY
Department:	Pathology
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	11/2007

Project Title:	Molecular and functional characterisation of novel tumour suppressor genes aberrantly down-regulated in colorectal cancer
Investigator(s):	Leung SY, Chan TL, Chen X, Yuen ST
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2008

Project Title:	Research Output Prize
Investigator(s):	Leung SY, Chan TL
Department:	Pathology
Source(s) of Funding:	Research Output Prize (in Faculty)
Start Date:	12/2009

Project Title:	Genomics study for new mechanism of tumour suppressor gene silencing by transcriptional interference in colorectal cancer
Investigator(s):	Leung SY, Chan TL, Lok S, Yuen ST
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2010

List of Research Outputs

Kempers M.J., Kuiper R.P., Ockeloen C.W., Chappuis P.O., Hutter P., Rahner N., Schackert H.K., Steinke V., Holinski-Feder E., Morak M., Kloor M., Büttner R., Verwiel E.T., van Krieken J.H., Nagtegaal I.D., Goossens M., van der Post R.S., Niessen R.C., Sijmons R.H., Kluijt I., Hogervorst F.B., Leter E.M., Gille J.J., Aalfs C.M., Redeker E.J., Hes F.J., Tops C.M., van Nesselrooij B.P., van Gijn M.E., Gómez García E.B., Eccles D.M., Bunyan D.J., Syngal S., Stoffel E.M., Culver J.O., Palomares M.R., Graham T., Velsher L., Papp J., Oláh E., Chan T.L., Leung S.Y., van Kessel A.G., Kiemeney L.A., Hoogerbrugge N. and Ligtenberg M.J., Risk of colorectal and endometrial cancers in EPCAM deletion-positive Lynch syndrome: a cohort study, Lancet Oncol. 2010, 12(1): 49-55.

Leung S.Y., Gene Expression Programme of Colon Crypt and Their Dysregulation in Carcinogenesis, The Inaugural Xiamen Winter Symposium, Xiamen University, Xiamen, China. 2011.

Leung S.Y., Hereditary Nonpolyposis Colorectal Cancer Syndrome (LynchSyndrome) - Relevance in Gynaecological Practice, Postgraduate Seminar 2011 organised by the Hong Kong College of Obstetricians and Gynaecologists . 2011.

Leung S.Y., Journal Editorial Board Membership, Journal of Clinical Pathology. 2011.

Leung S.Y., Keynote Session for Best Research Output Awardees “Gene Expression Programme of Colon Crypt and Pathways Involved in Intestinal Stem Cell Regulation”, Frontiers in Biomedical Research, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2010.

Leung S.Y., New Insights Into the Genetic and Epigenetic Mechanisms Causing Lynch Syndrome, The 9th Asia-Pacific Conference on Human Genetics, Hong Kong. 2010.

Researcher : Leung THY

Project Title:	23rd Lorne Cancer Conference Interaction of DNp73 and C35 promotes chemo-resistance in ovarian cancer cells
Investigator(s):	Leung THY
Department:	Obstetrics & Gynaecology
Source(s) of Funding:	URC/CRCG - Conference Grants for Teaching Staff
Start Date:	02/2011
Completion Date:	02/2011

Project Title:	Identification and characterization of cancer stem cells in cervical cancer
Investigator(s):	Leung THY, Ngan HYS
Department:	Obstetrics & Gynaecology
Source(s) of Funding:	Small Project Funding
Start Date:	03/2011

List of Research Outputs

Leung T.H.Y., Chan K.K.L., Chan D.W., Cheung A.N.Y. and Ngan H.Y.S., Interaction of DNp73 and C35 promotes chemoresistance in ovarian cancer cells, 23rd Lorne Cancer Conference, Melbourne, Australia. 2011.

Researcher : Li J

List of Research Outputs

Lo C.L.R., Tung K.K., Mak K.M., Fatima S., Zhou H., Poon R.T.P., Yuen R.M.F., Lai C.L., Li J., Luk J.M.C. and Ng I.O.L., Both tissue and serum dickkopf-1 (DKK-1) levels have clincopathologic and prognostic significance in hepatocellular carcinoma., Hepatology . 2010, 52(4 Suppl): 282A.

Researcher : Lo CK

List of Research Outputs

Wong G.W., Lo C.K., Szeto E.F. and Cheung A.N.Y., Efficacy of Abbott RealTime High Risk HPV test in evaluation of atypical squamous cells of undetermined significance from an Asian screening population., Journal of Clinical Virology. 2011, 51: 136-138.

Researcher : Lo CLR

Project Title:	Study of the role of Dickkopf-1 (DKK1) in liver cancer
Investigator(s):	Lo CLR, Ng IOL
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2010

Project Title:	61st Annual Meeting of the American Association for the Study of Liver Diseases Both tissue and serum Dickkopf-1 (DKK-1) levels have clinicopathologic and prognostic significance in hepatocellular carcinoma
Investigator(s):	Lo CLR
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Grants for Teaching Staff
Start Date:	10/2010
Completion Date:	11/2010

List of Research Outputs

Cheung A.N.Y., Lo C.L.R., Ho S.L., Kong P.L., Tipoe G. and Beh S.L., MULTI-MEDIA DIGITAL TUTORIAL FOR MEDICAL EDUCATION, Frontiers in Health and Medical Sciences Education HKU 2010.

Lo C.L.R., Tung K.K., Mak K.M., Fatima S., Zhou H., Poon R.T.P., Yuen R.M.F., Lai C.L., Li J., Luk J.M.C. and Ng I.O.L., Both tissue and serum dickkopf-1 (DKK-1) levels have clincopathologic and prognostic significance in hepatocellular carcinoma., Hepatology . 2010, 52(4 Suppl): 282A.

MA T.W., Lo C.L.R., CHENG Y.U.E. and Chim J.C.S., Multiple myeloma presenting as interstitial lung disease, Journal of Clinical Oncology. 2011.

Researcher : Loong F

List of Research Outputs

Gill H., Chan T., Lau W.H., Loong F., Hwang Y.Y., Wong C.S. and Khong P.L., Two tales of two lymphomas, Journal of Clinical Oncology. 2011, 29(20): e610-612.

Ho S.L., Loong F., Lam C.C.K., Anthony M. and Kwong Y.L., F-18 Fluorodeoxyglucose non-avid hepatosplenic T cell lymphoma: a diagnostic pitfall., Ann Hematol.. 2011.

Iqbal J., Weisenburger D.D., Chowdhury A., Tsai M.Y., Srivastava G., Greiner T.C., Kucuk C., Deffenbacher K., Vose J., Smith L., Au W.Y., Nakamura S., Seto M., Delabie J., Berger F., Loong F., Ko Y.H., Sng I., Liu X., Loughran T.P., Armitage J., Chan W.C. and International Peripheral T-cell Lymphoma Project , Natural killer cell lymphoma shares strikingly similar molecular features with a group of non-hepatosplenic γδ T-cell lymphoma and is highly sensitive to a novel aurora kinase A inhibitor in vitro, Leukemia. 2010, 25(2): 348-58.

Lee E.Y.P., Au Yeung K.L., Anthony M., Loong F. and Khong P.L., Utility of 18F-FDG PET/CT in identifying terminal ileal myeloid sarcoma in an asymptomatic patient., Am J Hematol.. 2011.

Wong K.Y., So J.C.C., Loong F., Chung L.P., Lam W.W.L., Liang R.H.S., Jin D. and Chim J.C.S., Epigenetic inactivation of the miR-124-1 in haematological malignancies, PLoS One. 2011, 22;6(4).

Wong M.K.Y., Loong F., Khong P.L., Kwong Y.L. and Leung A.Y.H., Mediastinal cryptococcosis masquerading as therapy-refractory lymphoma, Annals of Hematology. 2010, Epub.

Researcher : Lu L

Project Title:	Plasma cell development and its regulation in autoimmunity
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2007

Project Title:	Regulation of dendritic cell function and its therapeutic application in autoimmune diabetes
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	12/2007
Completion Date:	11/2010

Project Title:	Role of leptin in regulating B cell maturation and function
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2009

Project Title:	The regulatory B cell and its functional implication in autoimmune arthritis
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	12/2009
Completion Date:	05/2011

Project Title:	The role of IL-17 in modulating B cell functions duringin anti-viral immunity against H5N1 influenza infection in mice
Investigator(s):	Lu L, Zheng B
Department:	Pathology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2011

Project Title:	Role of regulatory B cells in modulating T cell functions
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	02/2011

List of Research Outputs

Lam Q.L.K., Wang S., Ko O.K., Kincade P.W. and Lu L., Leptin signaling maintains B-cell homeostasis via induction of Bcl-2 and Cyclin D1, Proc Natl Acad Sci U S A. 2010, 107(31): 13812-7.

Liang J., Zhang H., Hua B., Wang H., Lu L., Shi S., Hou Y., Zeng X., Gilkeson G.S. and Sun L., Allogenic Mesenchymal Stem Cells Transplantation in Refractory Systemic Lupus Erythematosus: a Pilot Clinical Study, Ann Rheum Dis. 2010, 69: 1423-1429.

Liang J., Gu F., Wang S., Hua B., Hou Y., Shi S., Lu L. and Sun L., Umbilical Cord-Derived Mesenchymal Stem Cells Transplantation Treats Diffuse Alveolar Hemorrhage in a SLE Patient, Nature Reviews Rheumatology. 2010, 6: 486-9.

Lu L., Roles of B cell activating factor in autoimmunity, 11th International Workshop on Autoantibodies and Autoimmunity. Shanghai China. 2011.

Lu L., B cell-targeted therapy for rheumatoid arthritis, 16th Chinese Rheumatology Congress. Changsha, China. 2011.

Lu L., B cell-targeted therapy for rheumatoid arthritis, Current Immunology. 2011, 31: 180-182.

Lu L., Current Immunology (Associate Editor-in-Chief). Chinese Society for Immunology, 2011.

Lu L., Distinguished Visitor, Singapore Immunology Network, Agency for Science Technology and Research, Singapore, 2010. 2010.

Lu L., Frontiers in B Cell Biology , International Union of Immunology Societies, 2011.

Lu L., International Journal of Rheumatic Diseases (Associate Editor), Asia Pacific League of Associations for Rheumatology, 2011.

Lu L. and Yang M., Novel function of BAFF in the induction of IL-10-producing regulatory B cells, The 14th International Congress of Immunology, Kansai, Japan. 2010.

Lu L., Regulatory B cells in autoimmune arthritis, International Forum for Rheumatoid Arthritis, Beijing, China, 2010. 2010.

Lu L., Role of B cells in autoimmune arthritis, The 14th Congress of Asia Pacific League of Association for Rheumatology (APLAR 2010), Hong Kong. 2010.

Lu L., Roles of B cell activating factor in autoimmunity, 11th International Workshop on Autoantibodies and Autoimmunity. Shanghai China. 2011.

Lu L., Roles of B cells in autoimmune arthritis, The 14th Congress of Asia Pacific League of Association for Rheumatology (APLAR 2010) . 2010.

Ma J., Wang S., Ma B., Mao C., Tong J., Yang M., Wu C., Jiao Z., Lu L. and Xu H., Dendritic cells engineered to express GITRL enhance therapeutic immunity in murine Lewis lung carcinoma, Cancer Lett. 2011, 301(2): 142-50.

Shi Y., Wang H., Su Z., Chen J., Xue Y., Wang S., He Z., Yang H., Zhou C., Kong F., Liu Y., Yang P., Lu L., Shao Q., Huang X. and Xu H., Differentiation Imbalance of Th1/ Th17 in Peripheral Blood Mononuclear Cells Might Contribute to Pathogenesis of Hashimoto's Thyroiditis, Scand J Immunol. 2010, 72(3): 250-5.

Sun L., Wang D., Liang J., Zhang H., Feng X., Wang H., Hua B., Liu B., Ye S., Hu X., Xu W., Zeng X., Hou Y., Gilkeson G.S., Silver R.M., Lu L. and Shi S., Umbilical cord mesenchymal stem cell transplantation in severe and refractory systemic lupus erythematosus, Arthritis Rheum. 2010, 62(8): 2467-75.

Wang D., Zhang H., Liang J., Gu Z., Ma X., Huang J., Lin J., Hou Y., Lu L. and Sun L., Effect of allogeneic bone marrow-derived mesenchymal stem cells transplantation in a polyI:C-induced primary biliary cirrhosis mouse model, Clin Exp Med. 2011, 11(1): 25-32.

Yao H., Ng S.S., Huo L.F., Chow B.K., Shen Z., Yang M., Sze J., Ko O., Li M., Yue A., Lu L., Bian X.W., Kung H.F. and Lin M.C., Effective melanoma immunotherapy with interleukin-2 delivered by a novel polymeric nanoparticle., Mol Cancer Ther. 2011, 10(6): 1082-92.

Yao H., Ng S.M., Huo L.F., Chow B.K.C., Shen Z., Ko K.H., Li M., Lu L., Bian X.W., Kung H.F. and Lin M.C., Effective melanoma immunotherapy with interleukin-2 delivered by a novel polymeric nanoparticle, Molecular Cancer Therapeutics. 2011, 10: 1082-1092.

Researcher : Ma ESK

List of Research Outputs

Farrell J.J., Sherva R.M., Chen Z.Y., Luo H.Y., Chu B.F., Ha S.Y., Li C.K., Lee A.C., Li R.C., Li C.K., Yuen H.L., So J.C.C., Ma E.S.K., Chan L.C., Chan V.N.Y., Sebastiani P., Farrer L.A., Baldwin C.T., Steinberg M.H. and Chui D.H., A 3-bp deletion in the HBS1L-MYB intergenic region on chromosome 6q23 is associated with HbF expression, Blood. 2011, 117(18): 4935-45.

Researcher : Ma SKY

Project Title:	The study of the interplay between microRNA-130b and TP53INP1 and their role in hepatocellular carcinoma
Investigator(s):	Ma SKY, Guan X, Chan KW
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2010
Completion Date:	07/2011

Project Title:	AACR 102nd Annual Meeting 2011 RNA-Seq identifies protein tyrosine kinase 6 (PTK6) as a candidate tumor-suppressor gene in esophageal squamous cell carcinoma
Investigator(s):	Ma SKY
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Grants for Teaching Staff
Start Date:	04/2011
Completion Date:	04/2011

Project Title:	Transcriptome sequencing (RNA-Seq) identifies protein tyrosine kinase 6 (PTK6) as a candidate tumor-suppressor gene in esophageal carcinoma (ESCC)
Investigator(s):	Ma SKY
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2011

List of Research Outputs

Lee K.W., Murthy S.R.K., Cawley N.X., Dhanvantari S., Hewitt S.M., Lou H., Lau T., Ma S.K.Y., Huynh T., Wesley R.A., Ng I.O.L., Pacak K., Poon R.T.P. and Loh Y.P., An N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers, The Journal of Clinical Investigation. 2011, 121: 880-892.

Lee K.W., Castilho A.G., Cheung C.H., Tang K.H., Ma S.K.Y. and Ng I.O.L., CD24+ liver tumor initiating cells drive self-renewal and tumor initiation through Stat3- mediated Nanog regulation, AACR 102nd Annual meddting 2011.

Lee K.W., Castilho A.G., Cheung C.H., Tang K.H., Ma S.K.Y. and Ng I.O.L., Lupeol targets liver tumor initiating cells through PTEN modulation, Hepatology. 2011, 53: 160-70.

Luk S.U., Lee K.W., Liu J.I., Lee D.T.W., Chiu Y.T., Ma S.K.Y., Ng I.O.L., Wong Y.C., Chan F.L. and Ling M.T., Chemopreventive effect of PSP through targeting of prostate cancer stem cell-like population, PLoS One. 2011, 6: e19804.

Ma S.K.Y., Associate Editor, American Journal of Cancer Research. 2011.

Ma S.K.Y., Cancer Stem Cells / Tumor-initiating Cells - Concepts, Methodologies And Therapeutic Implications, Hong Kong International Cancer Congress. 2010.

Ma S.K.Y., Cancer Stem Cells : Concepts, Methods and Implications in Carcinogenesis , 2nd International Course on Stem Cell Biology and Regenerative Medicine (The University of Hong Kong - The University of Toronto). 2011.

Ma S.K.Y., Dissecting cancer stem cells in hepatocellular carcinoma – CD133 and beyond, Forum on Strategic Research Themes in Biomedicine, The University of Hong Kong. 2011.

Ma S.K.Y., Hepatic cancer stem cells - CD133 and beyond, Stem Cell and Regenerative Medicine Consortium Lectures. 2011.

Ma S.K.Y. and Guan X., MiRegulators in cancer stem cells of solid tumors, Cell Cycle. 2011, 15: 571-2.

Ma S.K.Y., Kwan P.S., Chan Y.P., Fu L., Tang K.H., Tong M., Chan K.W. and Guan X., RNA-Seq identifies protein tyrosine kinase 6 (PTK6) as a candidate tumor-suppressor gene in esophageal squamous cell carcinoma , American Association for Cancer Research - Annual Meeting 2011.

Ma S.K.Y., Tang K.H., Chan Y.P., Lee K.W., Kwan P.S., Castilho A.G., Ng I.O.L., Man K., Wong N., To K.F., Zheng B., Lai P.B.S., Lo C.M., Chan K.W. and Guan X.Y., miR-130b promotes CD133(+) liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1, Cell Stem Cell. 2010, 7(6): 694-707.

Ma S.K.Y., Chan Y.P., Kwan P.S., Lee K.W., Yan M., Tang K.H., Ling M.T., Vielkind J.R., Guan X. and Chan K.W., microRNA-616 induces androgen-independent growth of prostate cancer cells by suppressing expression of tissue factor pathway inhibitor TFPI-2, Cancer Research. 2011, 71: 583-92.

Tang K.H., Ma S.K.Y., Kwan P.S., Chan Y.P., Lee K.W., Ng I.O.L., Guan X. and Chan K.W., CD133+ liver tumor-initiating cells promote tumor growth, angiogenesis and self-renewal through activation of the neurotensin / interleukin-8 signaling cascade, American Association for Cancer Reseach - Annual Meeting 2011.

Tong M., Tang K.H., Guan X. and Ma S.K.Y., Loss of Rab25 Expression Promotes Tumor Formation and Angiogenesis in Esophageal Squamous Cell Carcinoma , American Association for Cancer Research - Annual Meeting 2011.

Researcher : Mak CM

List of Research Outputs

Chen S.P.L., Poon D.W.T., Mak C.M., Kwong Y.L., Chan A.Y.W. and Tam S., Application of pharmacogenetics: UGT1A1*28 and nilotinib-induced unconjugated hyperbilirubinaemia in a patient with chronic myeloid leukaemia, Pathology. 2011, 43(3): 273-4.

Lam C.W., Lau K.C., Mak C.M., Tsang M.W. and Chan A.Y.W., Circulating fluorocytes at the first attack of acute intermittent porphyria: a missing link in the pathogenesis, Clinica Chimica Acta. 2011, 412(1-2): 208-12.

Lau K.C., Lam C.W., Law C.Y., Lai S.T., Tsang T.Y., To W.K., Leung K.F., Mak C.M., Poon D.W.T., Chan P.K. and Chan A.Y.W., Non-invasive screening of HLA-DPA1 and HLA-DPB1 alleles for persistent hepatitis B virus infection: susceptibility for vertical transmission and toward a personalized approach for vaccination and treatment, Clinica Chimica Acta. 2011, 412(11-12): 952-7.

Lee H.H.C., Mak C.M., Lam C.W., Yuen L.Y.P., Chan A.O.K., Shek C.C., Siu T.S., Lai C.K., Ching D.C.K., Siu C.W.K., Chen S.P.L., Law C.Y., Tai M.H.L., Tam S. and Chan A.Y.W., Analysis of inborn errors of metabolism: disease spectrum for expanded newborn screening in Hong Kong, Chinese Medical Journal (English Edition). 2011, 124(7): 983-9.

Lee H.H.C., Lai C.K., Siu T.S., Chan K.Y., Chan A.Y.W., Tam S., Mak C.M. and Lam C.W., Role of Postmortem Genetic Testing Demonstrated in a Case of Glutaric Aciduria Type II, Diagnostic Molecular Pathology . 2010, 19(3): 184-6.

Mak C.M., Sheng B., Lee H.H.C., Lau K.K., Chan W.T., Lam C.W. and Chan A.Y.W., Young-onset parkinsonism in a Hong Kong Chinese man with adult-onset Hallervorden-Spatz syndrome, International Journal of Neuroscience. 2011, 121(4): 224-7.

Siu C.W.K., Ma R.C., Lam C.W., Mak C.M., Yuen L.Y.P., Lo F.M., Chan K.W., Lam S.F., Ling S.C., Tong S.F., So W.Y., Chow C.C., Tang M.H., Tam W.H. and Chan A.Y.W., Molecular basis of von Hippel-Lindau syndrome in Chinese patients, Chinese Medical Journal (English Version). 2011, 124(2): 237-41.

Yeung W.L., Wong V.C., Chan K.Y., Hui J., Fung C.W., Yau E., Ko C.H., Lam C.W., Mak C.M., Siu S. and Low L., Expanding phenotype and clinical analysis of tyrosine hydroxylase deficiency, Journal of Child Neurology. 2011, 26(2): 179-87.

Researcher : Mak CY

List of Research Outputs

Mak C.Y., Siu K.Y., Wong G.W., Ngan H.Y.S., Wong E.S.Y. and Cheung A.N.Y., Downregulation of ASPP1 in gestational trophoblastic disease: correlation with hypermethylation, apoptotic activity and clinical outcome., Modern pathology. 2011, 24: 522-532.

Zhang H., Siu K.Y., Jiang L., Mak C.Y., Ngan H.Y.S., Wong G.W. and Cheung A.N.Y., Overexpressed PAK4 promotes proliferation, migration and invasion of choriocarcinoma., Carcinogenesis. 2011, 32: 765-771.

Researcher : Mak KM

List of Research Outputs

Lo C.L.R., Tung K.K., Mak K.M., Fatima S., Zhou H., Poon R.T.P., Yuen R.M.F., Lai C.L., Li J., Luk J.M.C. and Ng I.O.L., Both tissue and serum dickkopf-1 (DKK-1) levels have clincopathologic and prognostic significance in hepatocellular carcinoma., Hepatology . 2010, 52(4 Suppl): 282A.

Tsui Y.M., Tung K.K., Mak K.M. and Ng I.O.L., Dishevelled 3 (Dvl3) is upregulated and enhances cell migration and invasion in hepatocellular carcinoma , American Association for Cancer Research 102nd Annual Meeting 2011.

Researcher : Nanji AA

Project Title:	10th Congress of the International Society for Biomedical Research on Alcoholism Mechanisms of Apoptosis in Alcoholic Liver Disease
Investigator(s):	Nanji AA
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Grants for Teaching Staff
Start Date:	07/2000

Researcher : Ng IOL

Project Title:	Characterization of T-cadherin in hepatocellular carcinoma
Investigator(s):	Ng IOL, Chan DW
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Project Title:	Characterization of the roles of hepatitis B virus X protein in liver cancer
Investigator(s):	Ng IOL, Chan DW
Department:	Pathology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	09/2006

Project Title:	Outstanding Research Student Supervisor Award 2007-2008
Investigator(s):	Ng IOL
Department:	Pathology
Source(s) of Funding:	Outstanding Research Student Supervisor Award
Start Date:	10/2008

Project Title:	Role of mitotic checkpoint gene MAD1 (mitotic arrest deficient 1) in liver cancer
Investigator(s):	Ng IOL, Yam JWP
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2009

Project Title:	Study of the role of the tumor suppressor phosphatase and tensin homolog (PTEN) in liver cancer and metastasis
Investigator(s):	Ng IOL
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2009
Completion Date:	04/2011

Project Title:	Molecular Pathology of Liver Cancer - a Multidisciplinary Study
Investigator(s):	Ng IOL, Cheung ST, Ching YP, Guan X, Jin D, Lee KW, Poon RTP, Wong CM
Department:	Pathology
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	05/2010

Project Title:	Significance of cten dysregulation in hepatocarcinogenesis and cancer metastasis
Investigator(s):	Ng IOL, Yam JWP
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2010

Project Title:	Significance of cten dysregulation in hepatocarcinogenesis and cancer metastasis
Investigator(s):	Ng IOL, Yam JWP
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2011

Project Title:	RhoE dysregulation in liver cancer and metastasis
Investigator(s):	Ng IOL, Wong CM, Chan LK
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2011

List of Research Outputs

Chan C.P., Mak T.Y., Chin K.T., Ng I.O.L. and Jin D., The activity of liver-enriched and growth-suppressive transcription factor CREB-H is tightly regulated by N-linked glycosylation and ubiquitination, The Cold Spring Harbor Laboratory Meeting: Mechanisms and Models of Cancer, New York, USA. August, 2010.

Chan J., Ko F.C.F., Ng I.O.L. and Yam J.W.P., Integrin-linked kinase overexpression and its oncogenic role in promoting tumorigenicity of hepatocellular carcinoma, PLoS ONE. 2011, 6(2): e16984.

Chan S.C., Lo C.M., Ng K.K.C., Ng I.O.L., Yong B.H. and Fan S.T., Portal inflow and pressure changes in right liver living donor liver transplantation including the middle hepatic vein, Liver Transplantation. 2011, 17(2): 115-121.

Gao P., Wong C.C.L., Tung K.K., Lee M.F., Wong C.M. and Ng I.O.L., Deregulation of microRNA expression occurs early and accumulates in early stages of HBV-associated multistep hepatocarcinogenesis., Journal of Hepatology. Elsevier B.V., 2011, 54: 1177-1184.

Ko F.C.F., Chan L.K., Tung K.K., Scott S.W., Ng I.O.L. and Yam J.W.P., Akt phosphorylation of deleted in liver cancer 1 abrogates its suppression of liver cancer tumorigenesis and metastasis., Gastroenterology. Elsevier Inc., 2010, 139: 1397-1407.e6.

Ko F.C.F., Ng I.O.L. and Yam J.W.P., DLC1 (deleted in liver cancer 1), Atlas of Genetics and Cytogenetics in Oncology and Haematology. 2010.

Ko F.C.F., Chan L.K., Ng I.O.L. and Yam J.W.P., PKA Phosphorylation of Deleted in Liver Cancer 1 (DLC1) at serine-549 modulates its inhibitory activity in liver cancer tumourigenesis, The 3rd JCA-AACR Special Joint Conference, Chiba, Japan. 2011.

Lee K.W., Murthy S.R.K., Cawley N.X., Dhanvantari S., Hewitt S.M., Lou H., Lau T., Ma S.K.Y., Huynh T., Wesley R.A., Ng I.O.L., Pacak K., Poon R.T.P. and Loh Y.P., An N-terminal truncated carboxypeptidase E splice isoform induces tumor growth and is a biomarker for predicting future metastasis in human cancers, The Journal of Clinical Investigation. 2011, 121: 880-892.

Lee K.W., Castilho A.G., Cheung C.H., Tang K.H., Ma S.K.Y. and Ng I.O.L., CD24+ liver tumor initiating cells drive self-renewal and tumor initiation through Stat3- mediated Nanog regulation, AACR 102nd Annual meddting 2011.

Lee K.W., Castilho A.G., Cheung C.H., Tang K.H., Ma S.K.Y. and Ng I.O.L., Lupeol targets liver tumor initiating cells through PTEN modulation, Hepatology. 2011, 53: 160-70.

Liang L., Wong C.M., Ying Q., Fan N.Y., Huang S., Ding J., Yao J., Yan M., Li J., Yao M., Ng I.O.L. and He X., MicroRNA-125b suppressesed human liver cancer cell proliferation and metastasis by directly targeting oncogene LIN28B2, Hepatology. 2010, 52: 1731-40.

Lo C.L.R., Tung K.K., Mak K.M., Fatima S., Zhou H., Poon R.T.P., Yuen R.M.F., Lai C.L., Li J., Luk J.M.C. and Ng I.O.L., Both tissue and serum dickkopf-1 (DKK-1) levels have clincopathologic and prognostic significance in hepatocellular carcinoma., Hepatology . 2010, 52(4 Suppl): 282A.

Luk S.U., Lee K.W., Liu J.I., Lee D.T.W., Chiu Y.T., Ma S.K.Y., Ng I.O.L., Wong Y.C., Chan F.L. and Ling M.T., Chemopreventive effect of PSP through targeting of prostate cancer stem cell-like population, PLoS One. 2011, 6: e19804.

Ma S.K.Y., Tang K.H., Chan Y.P., Lee K.W., Kwan P.S., Castilho A.G., Ng I.O.L., Man K., Wong N., To K.F., Zheng B., Lai P.B.S., Lo C.M., Chan K.W. and Guan X.Y., miR-130b promotes CD133(+) liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1, Cell Stem Cell. 2010, 7(6): 694-707.

Mak W.Y.G., Chan M.L., Leong V.Y.L., Lee M.F., Yau T.O., Ng I.O.L. and Ching Y.P., Overexpression of a novel activator of PAK4, the CDK5 kinase-associated protein CDK5RAP3, promotes hepatocellular carcinoma metastasis, Cancer Research. 2011, 71: 2949-58.

Seto W.K., Ng M.M.T., Chan P., Ng I.O.L., Cheung S.C.W., Hung I.F.N., Yuen R.M.F. and Lai C.L., Ketamine-induced cholangiopathy: a case report., Am J Gastroenterol. 2011, 106(5): 1004-5.

Sze M.F., Wong L.T., Chu K.Y., Lee M.F., Yau T.O. and Ng I.O.L., Loss of phosphatase and tensin homolog enhances cell invasion and migration through AKT/Sp-1 transcription factor/matrix metalloproteinase 2 activation in hepatocellular carcinoma and has clinicopathologic significance, In: Keith D. Lindor, Hepatology. 2011, 53 Issue 5: 1558-1569.

Tang K.H., Ma S.K.Y., Kwan P.S., Chan Y.P., Lee K.W., Ng I.O.L., Guan X. and Chan K.W., CD133+ liver tumor-initiating cells promote tumor growth, angiogenesis and self-renewal through activation of the neurotensin / interleukin-8 signaling cascade, American Association for Cancer Reseach - Annual Meeting 2011.

Tsui Y.M., Tung K.K., Mak K.M. and Ng I.O.L., Dishevelled 3 (Dvl3) is upregulated and enhances cell migration and invasion in hepatocellular carcinoma , American Association for Cancer Research 102nd Annual Meeting 2011.

Wong C.C.L., Wong C.M., Tung K.K., Au L.K., Lee M.F., Poon R.T.P., Man K. and Ng I.O.L., The microRNA miR-139 suppresses metastasis and progression of hepatocellular carcinoma by down-regulating Rho-kinase 2, Gastroenterology. 2011, 140(1): 322-331.

Wong C.M., Wong C.C.L., Tung K.K., Au L.K., Lee M.F., Man K. and Ng I.O.L., MiR-139 suppresses metastasis and progression of hepatocellular carcinoma through regulation of Rho-Kinase 2 (ROCK2), International Liver Cancer Association Fourth Annual Conference . Montreal, QC, Canada, 2010.

Wong C.M. and Ng I.O.L., Molecular Pathogenesis of Hepatocellular, In: Wang, Xin Wei; Grisham, Joe W.; Thorgeirsson, Snorri S, Molecular Genetics of Liver Neoplasia. Springer, 2011, 373-396.

Wong C.M., Wong C.C.L., Ng Y.L., Au L.K., Ko F.C.F. and Ng I.O.L., Transcriptional repressive H3K9 and H3K27 methylations contribute to DNMT1-mediated DNA methylation recovery, American Association for Cancer Research (AACR) 102 st Annual meeting 2011.

Yang J., Yang W., Hirankarn N., Ye D.Q., Zhang Y., Pan H.F., Mok C.C., Chan T.M., Wong R.W.S., Mok M.Y., Lee K.W., Wong S.N., Leung A.M.H., Li X.P., Avihingsanon Y., Rianthavorn P., Deekajorndej T., Suphapeetiporn K., Shotelersuk V., Baum L., Kwan P., Lee T.L., Ho M.H.K., Lee P.P.W., Wong W.H.S., Zeng S., Zhang J., Wong C.M., Ng I.O.L., Garcia-Barcelo M.M., Cherny S.S., Tam P.K.H., Sham P.C., Lau W.C.S. and Lau Y.L., ELF1 is associated with systemic lupus erythematosus in Asian populations, Human Molecular Genetics. 2011, 20(3): 601-607.

Zhang Y., Yang W., Mok C.C., Chan T.M., Wong R.W.S., Mok T.M.Y., Lee K.W., Wong S.N., Leung A.M.H., Lee T.L., Ho M.H.K., Lee P.P.W., Wong W.H.S., Yang J., Zhang J., Wong C.M., Ng I.O.L., Garcia-Barcelo M.M., Cherny S.S., Tam P.K.H., Sham P.C., Lau W.C.S. and Lau Y.L., Two missense variants in UHRF1BP1 are indpendently associated with systemic lupus erythematosus in Hong Kong Chinese, Genes and Immunity. 2011, 12(3): 231-234.

Researcher : Ng RK

Project Title:	The role of Jarid1 histone demethylases in the development of haematopoietic stem cell
Investigator(s):	Ng RK
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2009
Completion Date:	06/2011

Project Title:	Genome-wide analysis of DNA methylation patterns in MLL-rearranged leukaemia stem cells
Investigator(s):	Ng RK, Chan LC
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2009

Project Title:	The functional role of Bmi-1 in self-renewal of haematopoietic stem cell
Investigator(s):	Ng RK
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2010

Project Title:	The functional roles of histone H3K9 demethylase Jmjd2 family in determination of trophoblast lineages
Investigator(s):	Ng RK, Lee CYL
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2010

Project Title:	Gordon Research Conference on Cancer Genetics & Epigenetics Promoter hypomethylation mediated by Mll-Een fusion protein dysregulates Hox gene expression in an invertor leukemia mouse model
Investigator(s):	Ng RK
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Grants for Teaching Staff
Start Date:	01/2011
Completion Date:	01/2011

List of Research Outputs

Ng R.K., Epigenetic Regulation in Stem Cells, 2nd International Course on Stem Cell Biology and Regenerative Medicine. Toronto Canada, 2011.

Ng R.K., Inspirational talk for current RPGs, Department of Pathology. 2011.

Waye M.M.Y., Baum L., Boyde T.R.C., Chan K.K.K., Cherny S.S., Choy F., Garcia-Barcelo M.M., Gong Z., Kagawa H., Kotaka M., Lee C.Y., Lee S.M.Y., Li H.Y., Meng H., Ng R.K., Ng T.B., Pollard J., Qi R., Shen D.W., Tam S.S.W., Tsang F.S.Y., Wasylyk B., Xue H. and Siu C.O., Journal of Biochemistry and Molecular Biology in the Post Genomic Era. 2010.

Researcher : Ng TT

List of Research Outputs

Chen J., Gomes A.R., Monteiro L.J., Wong S.Y., Wu L.H., Ng T.T., Karadedou C.T., Millour J., Ip Y.C., Cheung Y.N., Sunters A., Chan Y.K., Lam E.W. and Khoo U.S., Constitutively nuclear FOXO3a localization predicts poor survival and promotes Akt phosphorylation in breast cancer, PLoS One. 2010, 5(8): e12293.

Researcher : Ng YL

List of Research Outputs

Wong C.M., Wong C.C.L., Ng Y.L., Au L.K., Ko F.C.F. and Ng I.O.L., Transcriptional repressive H3K9 and H3K27 methylations contribute to DNMT1-mediated DNA methylation recovery, American Association for Cancer Research (AACR) 102 st Annual meeting 2011.

Researcher : Nicholls JM

Project Title:	Susceptibility of the upper respiratory tract to influenza virus infection following desialyation
Investigator(s):	Nicholls JM, Chan MCW, Kwong DLW
Department:	Pathology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2009

Project Title:	Investigations into influenza receptor binding and novel therapies in an ex-vivo setting
Investigator(s):	Nicholls JM
Department:	Pathology
Source(s) of Funding:	Croucher Senior Medical Research Fellowships
Start Date:	10/2009

Project Title:	Influenza and sialic acid linked glycan interactions using virus like pseudoparticles (VLP) and STD-NMR
Investigator(s):	Nicholls JM, Poon LLM
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2009

Project Title:	Prevention and treatment of swine origin influenza virus (S-OIV) though the use of interferon - an in vivo and ex vivo study
Investigator(s):	Nicholls JM
Department:	Pathology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2010

Project Title:	Sialoglyco2010 An update of inhibition of influenza infection by sialidase treatment
Investigator(s):	Nicholls JM
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Grants for Teaching Staff
Start Date:	08/2010

List of Research Outputs

Chan M.C.W., Chan W.Y., Yen H., Yu C.L., Yuen K.M., Tang L.L.S., Li C.L., Kang S.R., Hui F.F., Lai W.W.K., Sihoe A.D.L., Guan Y., Nicholls J.M. and Peiris J.S.M., ) Tropism and innate host response of the 2009 pandemic H1N1 influenza virus compared with related swine influenza viruses and reassortants in ex vivo and in vitro cultures of the human respiratory tract and conjunctiva, Options for the Control of Influenza VII, 2010.

Chan M.C.W., Chan W.Y., Yen H., Lee M.Y., Guan Y., Nicholls J.M. and Peiris J.S.M., Comparing the tropism of the pandemic H1N1/2009 influenza virus with seasonal influenza virus, related swine influenza viruses and reassortants in ex vivo and in vitro cultures of human conjunctiva and respiratory tract., 4th Annual Center of Excellence for Influenza Research and Surveillance Network Meeting, Woodcliff Hotel and Conference Center 199 Woodcliff Drive, Fairport, NY 14450 . 2010.

Chan M.C.W., Chan W.Y., Lee M.Y., Cheung C.Y., Nicholls J.M. and Peiris J.S.M., Pathogenesis of swine-origin influenza H1N1 virus (S-OIV) in humans: studies of viral tropism and host response in primary differentiated human respiratory epithelial cell cultures in vitro and in ex vivo, Health Research Symposium 2010.

Chan M.C.W., Chan W.Y., Yen H., Yu C.L., Yuen K.M., Tang L.L.S., Li C.L., Kang S.R., Hui F.F., Lai W.W.K., Sihoe A.D.L., Guan Y., Nicholls J.M. and Peiris J.S.M., Tropism and innate host response of the 2009 pandemic H2N2 influenza virus compared with related swine influenza viruses and reassortants in ex vivo and in vitro cultures of the human respiratory tract and conjunctiva, Influenza and other respiratory viruses. 2011, 5 (S1): 54-55.

Chan W.Y., Chan M.C.W., Li S.Y., Nicholls J.M. and Peiris J.S.M., Neutrophil extracellular trap formation in acute influenza virus infection, Keystone Symposia 2011 - Pathogenesis of influenza: virus-host interaction, 2011 . 2011.

Chan W.Y., Hui F.F., Kang S.R., Yu C.L., Nicholls J.M. and Chan M.C.W., Replication and innate host response of influenza A virus in human lung microvascular endothelial cells: insights into systemic dissemination and pathogenesis , Options for the Control of Influenza VII. 2010.

Chan W.Y., Yuen K.M., Yu C.L., Tang L.L.S., Li C.L., Nicholls J.M. and Chan M.C.W., Replication of avian and seasonal influenza viruses in human bronchus and lung, Influenza and other respiratory viruses. 2011, 5: 425-426.

Chan W.Y., Chan M.C.W., Nicholls J.M. and Peiris J.S.M., Replication of avian and seasonal influenza viruses in human bronchus and lung, Options for the Control of Influenza VII. 2010.

Hui F.F., Chan W.Y., Fung K.H.Y., Yu C.L., Tsao G.S.W., Chan M.C.W. and Nicholls J.M., The regional distribution of different types of influenza receptors in cultured human alveolar epithelial cells and correlation with in vitro infection, Influenza and other respiratory viruses. 2011, 5(S1): 436-437.

Jia D., Rahbar R., Chan W.Y., Lee M.Y., Chan M.C.W., Wang B.X., Baker D.P., Sun B., Peiris J.S.M., Nicholls J.M. and Fish E.N., Influenza virus non-structural protein 1 (NS1) disrupts interferon signaling. , PLoS One. 2010, 5 (11): e13927.

Lai J.C.C., Nicholls J.M., Peiris J.S.M. and Garcia J., Formation of virus-like particles from human cell lines exclusively expressing Influenza Neuraminidase, International Network Institut Pasteur Annual meeting. 2010.

Leung C.Y.H., Nicholls J.M., Sia S.F., Hui P.Y., Cheung P.P.H., Chow C.K., Chan W.Y., Chan M.C.W. and Peiris J.S.M., Toll-like Receptor 3 signaling contributes to enhanced disease severity in H5N1 but not pandemic H1N1 infection in mice, Keystone Symposia on Molecular and Cellular Biology: Pathogenesis of Influenza: virus-host interactions. 2011.

Li C.L., Chan W.Y., Hui F.F., Kang S.R., Yu C.L., Nicholls J.M. and Chan M.C.W., Replication and innate host response of influenza A virus in lung microvascular endothelial cells: new insights into systemic infection and pathogenesis, Influenza and other respiratory viruses. 2011, 5 (S1): 287-288.

Ng Y.P., Lee M.Y., Cheung K.W., Nicholls J.M., Peiris J.S.M. and Ip N.Y., Avian influenza H5N1 virus induces cytopathy and proinflammatory cytokine responses in human astrocytic and neuronal cell lines, Neuroscience. 2010, 168(3): 613-23.

Nicholls J.M., Chan W.Y., Li C.L., Walther T.J. and Haslam S.T.U.A.R.T., Receptors in the Human Respiratory Tract - Making and Breaking the Links, Keystone Symposia on Molecular and Cellular Biology: Pathogenesis of Influenza: virus-host interactions. 2011.

Peiris J.S.M., Chan M.C.W., Chan W.Y. and Nicholls J.M., Human ex vivo and in vitro Experimental Models for Studying Influenza Pathogenesis, Keystone Symposia on Molecular and Cellular Biology: Pathogenesis of Influenza: virus-host interactions. 2011.

Yen H., Liang C., Wu C., Forrest H., Ferguson A., Choy K.T., Jones J., Wong D.D.Y., Cheung P.H.P., Hsu C., Li O.T.W., Yuen K.M., Chan W.Y., Poon L.L.M., Chan M.C.W., Nicholls J.M., Krauss S., Wong C.H., Guan Y., Webster R.G., Webby R. and Peiris J.S.M., Hemagglutinin-neuraminidase balance confers respiratory droplet transmissibility of the pandemic H1N1 influenza virus in ferrets, Keystone Symposia (Pathogenesis of Influenza: Virus-Host Interactions), May 23-28, 2011, Hong Kong SAR. 2011.

Yen H., Forrest H., Cheung P.P.H., Wong D.D.Y., Li O.T.W., Krauss S., Ferguson A., Crumpton J.C., Jones J., Choy K.T., Ma S.K., Poon L.L.M., Smith G.J., Nicholls J.M., Guan Y., Webster R.G., Webby R. and Peiris J.S.M., Transmissibility of pandemic H1N1 and genetically related swine influenza viruses in ferrets, Influenza Other Respi Viruses. 2011, 5: 85-87.

Yen H., Forrest H., Cheung P.P.H., Wong D.D.Y., Li O.T.W., Krauss S., Ferguson A., Crumpton J.C., Jones J., Choy K.T., Ma S.K., Poon L.L.M., Smith G.J., Nicholls J.M., Guan Y., Webster R., Webby R. and Peiris J.S.M., Transmissibility of pandemic H1N1 and genetically related swine influenza viruses in ferrets, Options for the Control of Influenza VII, 2010, Hong Kong. 2010.

Yu C.L., Chan W.Y., Wang J., Nicholls J.M., Peiris J.S.M., Mason R.J. and Chan M.C.W., Avian influenza H5N1 and seasonal H1N1 virus infection and innate host responses in human alveolar type II epithelial cells and macrophages, Options for the Control of Influenza VII. 2010.

Yuen K.M., Chan W.Y., Mok K.P., Wong A.C.N., Kang S.R., Nicholls J.M. and Chan M.C.W., Differential onset of apoptosis in avian influenza H5N1 and seasonal H1N1 virus infected human bronchial and alveolar epithelial cell, an in vitro and ex vivo study, Options for the Control of Influenza VII. 2010.

Yuen K.M., Chan W.Y., Mok K.P., Wong C.N., Kang S.R., Nicholls J.M. and Chan M.C.W., Differential onset of apoptosis in avian influenza H5N1 and seasonal H1N1 virus infected human bronchial and alveolar epithelial cells: an in vitro and ex vivo study, Influenza and other respiratory viruses. 2011, 5 (S1): 437-438.

Researcher : Poon DWT

List of Research Outputs

Chen S.P.L., Poon D.W.T., Mak C.M., Kwong Y.L., Chan A.Y.W. and Tam S., Application of pharmacogenetics: UGT1A1*28 and nilotinib-induced unconjugated hyperbilirubinaemia in a patient with chronic myeloid leukaemia, Pathology. 2011, 43(3): 273-4.

Lau K.C., Lam C.W., Law C.Y., Lai S.T., Tsang T.Y., To W.K., Leung K.F., Mak C.M., Poon D.W.T., Chan P.K. and Chan A.Y.W., Non-invasive screening of HLA-DPA1 and HLA-DPB1 alleles for persistent hepatitis B virus infection: susceptibility for vertical transmission and toward a personalized approach for vaccination and treatment, Clinica Chimica Acta. 2011, 412(11-12): 952-7.

Researcher : Siu CWK

List of Research Outputs

Lee H.H.C., Mak C.M., Lam C.W., Yuen L.Y.P., Chan A.O.K., Shek C.C., Siu T.S., Lai C.K., Ching D.C.K., Siu C.W.K., Chen S.P.L., Law C.Y., Tai M.H.L., Tam S. and Chan A.Y.W., Analysis of inborn errors of metabolism: disease spectrum for expanded newborn screening in Hong Kong, Chinese Medical Journal (English Edition). 2011, 124(7): 983-9.

Siu C.W.K., Ma R.C., Lam C.W., Mak C.M., Yuen L.Y.P., Lo F.M., Chan K.W., Lam S.F., Ling S.C., Tong S.F., So W.Y., Chow C.C., Tang M.H., Tam W.H. and Chan A.Y.W., Molecular basis of von Hippel-Lindau syndrome in Chinese patients, Chinese Medical Journal (English Version). 2011, 124(2): 237-41.

Researcher : Siu KY

Project Title:	Effects of folate and folate receptor on ovarian and endometrial cancer: an in vitro study
Investigator(s):	Siu KY, Cheung ANY
Department:	Pathology
Source(s) of Funding:	American Institute for Cancer Research (AICR) - General Award
Start Date:	07/2006

Project Title:	p21-activated kinase 4: a prognostic and therapeutic target for ovarian carcinoma?
Investigator(s):	Siu KY, Cheung ANY, Ngan HYS
Department:	Pathology
Source(s) of Funding:	The Hong Kong Anti-Cancer Society (HKACS) - General Award
Start Date:	10/2007

Project Title:	Characterization of αPIX in ovarian cancer
Investigator(s):	Siu KY, Cheung ANY
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2009
Completion Date:	02/2011

Project Title:	Differential impact of reduced folate carrier and folate receptor alpha in ovarian cancer
Investigator(s):	Siu KY, Cheung ANY
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2010
Completion Date:	08/2011

Project Title:	Unraveling the role of Pak4 in ovarian cancer chemoresistance
Investigator(s):	Siu KY, Cheung ANY
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2011
Completion Date:	08/2011

List of Research Outputs

Jiang L., Siu K.Y., Wong G.W., Tam K.F., Ngan H.Y.S., Wong S.Y., Chan H.Y. and Cheung A.N.Y., Overexpression of proto-oncogene FBI-1 activates membrane type 1-matrix metalloproteinase in association with adverse outcome in ovarian cancers., Molecular cancer. 2010, 9: 318.

Mak C.Y., Siu K.Y., Wong G.W., Ngan H.Y.S., Wong E.S.Y. and Cheung A.N.Y., Downregulation of ASPP1 in gestational trophoblastic disease: correlation with hypermethylation, apoptotic activity and clinical outcome., Modern pathology. 2011, 24: 522-532.

Siu K.Y., Wong E.S.Y., Chan H.Y., Kong S.H., Woo N.W., Tam K.F., Ngan H.Y.S., Chan Q.K.Y., Chan D.C., Chan Y.K. and Cheung A.N.Y., Differential expression and phosphorylation of Pak1 and Pak2 in ovarian cancer: effects on prognosis and cell invasion, International Journal of Cancer. 2010.

Siu K.Y., Wong C.H., Xia W., Mruk D.D., Lee W.W.M. and Cheng C.Y., The beta-1-integrin-p-fak-p130cas-dock180-rhoavinculin is a novel regulatory protein complex at the apical ectoplasmic specialization in adult rat testes. , Spermatogenesis. 2011, 1: 73-86.

Siu K.Y., Chan H.Y., Kong S.H., Wong E.S.Y., Wong G.W., Ngan H.Y.S., Tam K.F., Tsao G.S.W. and Cheung A.N.Y., p21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients., Proceedings of the National Academy of Sciences of the United States of America . 2010, 107: 18622-18627.

Siu K.Y., Chan H.Y., Kong S.H., Wong S.Y., Wong G.W., Ngan H.Y.S., Tam K.F., Zhang H., Li Z., Chan Q.K.Y., Tsao G.S.W., Strömblad S. and Cheung A.N.Y., p21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients, PNAS. 2010, 107(43): 18622-18627.

Zhang H., Siu K.Y., Jiang L., Mak C.Y., Ngan H.Y.S., Wong G.W. and Cheung A.N.Y., Overexpressed PAK4 promotes proliferation, migration and invasion of choriocarcinoma., Carcinogenesis. 2011, 32: 765-771.

Researcher : So JCC

Project Title:	Role of chromosomal 6q23 region in the modulation of HbF production
Investigator(s):	So JCC, Ma ESK, Song Y
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2007

Project Title:	Genetic diagnosis of hereditary spherocytosis in Chinese - a prototype for studying hereditary haemolytic anaemias
Investigator(s):	So JCC
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2011

List of Research Outputs

Chan J.F.W., Hwang G.Y., Lamb S., Chan G.S.W., So J.C.C., Leung S.S., To K.K.W., Li W.S., Cheng V.C.C. and Yuen K.Y., Pneumococcal native aortic valve endocarditis with mycotic abdominal aortic aneurysm, paraspinal and iliopsoas abscesses and pneumonia revealing a multiple myeloma, J Med Microbiol. 2011, 60(Pt 6): 851-5.

Chan T.S., Au W.Y., Lam K., Lam Y.F., So J.C.C., Leung A.Y.H., Tse E.W.C., Lie A.K.W. and Kwong Y.L., Donor cell leukaemia after allogeneic haematopoietic SCT followed by prolonged thalidomide maintenance for multiple myeloma, Bone Marrow Transplant. 2011, [Epub ahead of print].

Farrell J.J., Sherva R.M., Chen Z.Y., Luo H.Y., Chu B.F., Ha S.Y., Li C.K., Lee A.C., Li R.C., Li C.K., Yuen H.L., So J.C.C., Ma E.S.K., Chan L.C., Chan V.N.Y., Sebastiani P., Farrer L.A., Baldwin C.T., Steinberg M.H. and Chui D.H., A 3-bp deletion in the HBS1L-MYB intergenic region on chromosome 6q23 is associated with HbF expression, Blood. 2011, 117(18): 4935-45.

Gill H., Yip T.P.S., So J.C.C. and Lo W.K., Quiz page October 2010: Anemia in a patient newly transferred from peritoneal dialysis to hemodialysis, Am J Kidney Dis. 2010, 56(4): A37-9.

Lee P.P.W., Lee T.L., Ho M.H.K., Chong C.Y., So J.C.C. and Lau Y.L., An infant with severe congenital neutropenia presenting with persistent omphalitis: case report and literature review, Hong Kong Journal of Paediatrics (new series). 2010, 15: 289-298.

So J.C.C., Leung R.Y.Y., Yip S.F., Chan S.Y., Lam C.C.K., Chan G.C.F., Chim S. and Chan L.C., Common association of haemolytic uraemic syndrome with invasive Streptococcus pneumoniae infection in five Chinese paediatric patients, Hong Kong Med J. 2011, 17(3): 237-41.

So J.C.C., Chan A.Y.Y., Chow E.Y.D., Lin S.Y., Yip S.F., Szeto S.C. and Chan L.C., Haemoglobin Bonn in a Chinese family as a cause of spurious hypoxaemia measured by pulse oximetry, J Clin Pathol. 2010, 63(10): 947-9.

So J.C.C., Chan A.Y.Y., Luo H.Y., Verhovsek M., Chui D.H., Ling S.C. and Chan L.C., Hb A2 Hong Kong - A novel δ-globin variant in a Chinese family masks the diagnosis of β-thalassemia trait, Hemoglobin. 2010, 35(2): 162-5.

So J.C.C., How should we type hereditary spherocytosis?, Seminar of The Hong Kong Association of Blood Transfusion and Haematology. 2011.

Tsang S.T.Y. and So J.C.C., Role of Chromosomal 6q23 Region in the Modulation of HbF Production, 17th Hemoglobin Switching Conference, 2-5 September 2010, St. John’s College, Oxford, UK. 2010.

Tse E.W.C., So J.C.C., Cheung W.W.W. and Kwong Y.L., T-cell prolymphocytic leukaemia: spontaneous immunophenotypical switch from CD4 to CD8 expression, Ann Hematol. 2010, 90(4): 479-81.

Wong K.Y., So J.C.C., Loong F., Chung L.P., Lam W.W.L., Liang R.H.S., Jin D. and Chim J.C.S., Epigenetic inactivation of the miR-124-1 in haematological malignancies, PLoS One. 2011, 22;6(4).

Wong K.Y., Liang R.H.S., So J.C.C., Jin D., Costello J.F. and Chim J.C.S., Epigenetic silencing of MIR203 in multiple myeloma, Br J Haematol. 2011, [Epub ahead of print].

Researcher : Srivastava G

Project Title:	Genetic and epigenetic mechanisms and clinicopathological significance of the silencing of a 6q22.33-q23.2 putative tumor suppressor PTPRK (protein tyrosine phosphatase, receptor type, kappa) gene in extranodal NK/T-cell lymphoma, nasal type
Investigator(s):	Srivastava G, Liang RHS
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2007
Completion Date:	08/2010

Project Title:	Identification of direct and indirect targets of the del 6q putative tumor suppressor PRDM1 gene in NK cells, and the role of the aberrant expression of these PRDM1 downstream target genes in the pathogenesis of NK-cell malignancies
Investigator(s):	Srivastava G, Liang RHS
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2009

Project Title:	Inactivation of the transcriptional repressor PRDM1 and imbalance in the expression of PRDM1 ?and ?isoforms in NK-cell malignancies, and their roles in the pathogenesis
Investigator(s):	Srivastava G, Liang RHS
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2009

Project Title:	Tumor suppressor role of PRKCBP1, a novel translocation partner of IGH gene, in the pathogenesis of gastric and other B-cell non-Hodgkin’s lymphomas
Investigator(s):	Srivastava G
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2011

List of Research Outputs

Cheng Y., Geng H., Cheng S.H., Liang P., Bai Y., Li J., Srivastava G., Ng M.H., Fukagawa T., Wu X., Chan A.T. and Tao Q., KRAB Zinc Finger Protein ZNF382 Is a Proapoptotic Tumor Suppressor That Represses Multiple Oncogenes and Is Commonly Silenced in Multiple Carcinomas, Cancer Res. 2010, 70(16): 6516-26.

Cheung P.P.Y., Deng W., Man C.W.Y., Tse W.W., Srivastava G., Law S.Y.K., Tsao G.S.W. and Cheung A., Genetic alterations in a telomerase-immortalized human esophageal epithelial cell line: Implications for carcinogenesis, Cancer Letters. 2010, 293(1): 41-51.

Dong G., Chanudet E., Zeng N., Appert A., Chen W.Y.W., Au W.Y., Hamoudi R., Watkins A.J., Ye H., Liu H., Gao Z., Chuang S.S., Srivastava G. and Du M.Q., A20, ABIN-1/2 and CARD11 mutations and their prognostic value in gastrointestinal diffuse large B-cell lymphoma, Clin Cancer Res. 2011, [Epub ahead of print].

Iqbal J., Weisenburger D.D., Chowdhury A., Tsai M.Y., Srivastava G., Greiner T.C., Kucuk C., Deffenbacher K., Vose J., Smith L., Au W.Y., Nakamura S., Seto M., Delabie J., Berger F., Loong F., Ko Y.H., Sng I., Liu X., Loughran T.P., Armitage J., Chan W.C. and International Peripheral T-cell Lymphoma Project , Natural killer cell lymphoma shares strikingly similar molecular features with a group of non-hepatosplenic γδ T-cell lymphoma and is highly sensitive to a novel aurora kinase A inhibitor in vitro, Leukemia. 2010, 25(2): 348-58.

Jacobs C.L., Patel A., Jima D., Liu Q., Greenough A., Zhang J., Dunphy C., Richards K., Choi W.L., Srivastava G., Evens A.M., Gordon L.I., Czader M., Rizzieri D.A., Lagoo A.S., Mann K.P., Flowers C.R., Bernal-Mizrachi L., Naresh K., Luftig M., Chadburn A., Hsi E., Thompson M.A., Gill J. and Dave S., Alternative Splicing Is a Major Mechanism of Gene Regulation In Diffuse Large B Cell Lymphoma, The 52nd American Society of Hematology Annual Meeting and Exposition. 2010.

Jima D.D., Zhang J., Jacobs C.J., Richards K.L., Dunphy C.H., Choi W.L., Au W.Y., Srivastava G., Czader M.B., Rizzieri D.A., Lagoo A.S., Lugar P.L., Mann K.P., Flowers C.R., Bernal-Mizrachi L., Naresh K.N., Evens A.M., Gordon L.I., Luftig M.A., Friedman D.R., Weinberg J.B., Thompson M.A., Gill J.I., Liu Q., How T., Grubor V., Gao Y., Patel A., Wu H., Zhu J., Blobe G.C., Lipsky P.E., Chadburn A. and Dave S.S., Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs, Blood. 2010, 116: e118-e127.

Li J., Ying J., Fan Y., Wu L., Ying Y., Chan A.T., Srivastava G. and Tao Q., WNT5A antagonizes WNT/beta-catenin signaling and is frequently silenced by promoter CpG methylation in esophageal squamous cell carcinoma, Cancer Biol Ther. 2010, 10(6).

Lo H.Y.P., Lung H.L., Cheung A.K.L., Apte S.S., Chan K.W., Kwong F.M., Ko J.M.Y., Cheng Y., Law S.Y.K., Srivastava G., Zabarovsky E.R., Tsao G.S.W., Tang J.C., Stanbridge E.J. and Lung M.L., Extracellular protease ADAMTS9 suppresses esophageal and nasopharyngeal carcinoma tumor formation by inhibiting angiogenesis, Cancer Res. 2010, 70(13): 5567-76.

Low J.S., Tao Q., Ng K.M., Goh H.K., Shu X.S., Woo W.L., Ambinder R.F., Srivastava G., Shamay M., Chan A.T., Popescu N.C. and Hsieh W.S., A novel isoform of the 8p22 tumor suppressor gene DLC1 suppresses tumor growth and is frequently silenced in multiple common tumors, Oncogene. 2011, 30(16): 1923-35.

Yuen H.F., McCrudden C.M., Chan K.K., Chan Y.P., Wong M.L.Y., Chan Y.K., Khoo U.S., Law S., Srivastava G., Lappin T.R., Chan K.W. and El-Tanani M., The role of pea3 group transcription factors in esophageal squamous cell carcinoma, Am J Pathol. 2011, 179 (2): 992-1003.

Zeng N., Dong G., Bi Y., Chanudet E., Huang Y., Appert A., Chen W.Y.W., Au W.Y., Hamoudi R.A., Watkins A.J., Ye H., Liu H., Zhu X., Zou L., Chen R., Gao Z., Chuang S.S., Srivastava G. and Du M.Q., Genetic abnormalities of NF-kB regulators in ocular adnexal MALT lymphoma and gastrointestinal DLBCL, The 3rd UK & Ireland NF-kB meeting. 2011.

Researcher : Sze MF

Project Title:	The role of Hepatitis B virus X protein in dysfunction of chromosomal segregation machinery via-interaction with BUBR1 in hepatocellular carcinoma
Investigator(s):	Sze MF, Ng IOL
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	12/2007

List of Research Outputs

Sze M.F., Wong L.T., Chu K.Y., Lee M.F., Yau T.O. and Ng I.O.L., Loss of phosphatase and tensin homolog enhances cell invasion and migration through AKT/Sp-1 transcription factor/matrix metalloproteinase 2 activation in hepatocellular carcinoma and has clinicopathologic significance, In: Keith D. Lindor, Hepatology. 2011, 53 Issue 5: 1558-1569.

Researcher : Szeto EF

List of Research Outputs

Cheung A.N.Y., Wong G.W., Yang M.S., Tsang C.H., Ji S.L., Szeto E.F., Wong E.S.Y. and Ngan H.Y.S., Microarray-in-microwell HPV Profiling of Atypical Squamous cells of Undetermined Significance in an Asian Screening Population , 26th International Papillomavirus Conference, Montreal, Canada. 2010.

Wong G.W., Lo C.K., Szeto E.F. and Cheung A.N.Y., Efficacy of Abbott RealTime High Risk HPV test in evaluation of atypical squamous cells of undetermined significance from an Asian screening population., Journal of Clinical Virology. 2011, 51: 136-138.

Researcher : Tai MHL

List of Research Outputs

Lee H.H.C., Mak C.M., Lam C.W., Yuen L.Y.P., Chan A.O.K., Shek C.C., Siu T.S., Lai C.K., Ching D.C.K., Siu C.W.K., Chen S.P.L., Law C.Y., Tai M.H.L., Tam S. and Chan A.Y.W., Analysis of inborn errors of metabolism: disease spectrum for expanded newborn screening in Hong Kong, Chinese Medical Journal (English Edition). 2011, 124(7): 983-9.

Researcher : Tam S

List of Research Outputs

Chen S.P.L., Poon D.W.T., Mak C.M., Kwong Y.L., Chan A.Y.W. and Tam S., Application of pharmacogenetics: UGT1A1*28 and nilotinib-induced unconjugated hyperbilirubinaemia in a patient with chronic myeloid leukaemia, Pathology. 2011, 43(3): 273-4.

Lee A.M., Chu L.W., Chong C.S., Chan S.Y., Tam S., Lam K.S.L. and Lam T.P., Relationship between symptoms of androgen deficiency and psychological factors and quality of life among Chinese men, Int J Androl. 2010, 33(5): 755-63.

Lee H.H.C., Mak C.M., Lam C.W., Yuen L.Y.P., Chan A.O.K., Shek C.C., Siu T.S., Lai C.K., Ching D.C.K., Siu C.W.K., Chen S.P.L., Law C.Y., Tai M.H.L., Tam S. and Chan A.Y.W., Analysis of inborn errors of metabolism: disease spectrum for expanded newborn screening in Hong Kong, Chinese Medical Journal (English Edition). 2011, 124(7): 983-9.

Lee H.H.C., Lai C.K., Siu T.S., Chan K.Y., Chan A.Y.W., Tam S., Mak C.M. and Lam C.W., Role of Postmortem Genetic Testing Demonstrated in a Case of Glutaric Aciduria Type II, Diagnostic Molecular Pathology . 2010, 19(3): 184-6.

Li R.H.W., Lee V.C.Y., Yeung T.W.Y., Tam S., Wong E.W.K., Yeung W.S.B., Ng E.H.Y. and Ho P.C., Relationship between anti-Mullerian hormone, obesity and insulin resistance in women with polycystic ovary syndrome, The 8th Conference of the Pacific Rim Society for Fertility and Sterility, May 27-29, 2011, Hong Kong Convention and Exhibition Centre.. 2011.

Tang S.C.W., Lin M., Tam S., Au W.S., Ma K.M., Yap D.Y., Ho Y.W. and Lai K.N., Aliskiren combined with losartan in immunoglobulin A nephropathy: an open-labeled pilot study. Proceedings of the World Congress of Nephrology April 2011, J Am Soc Nephrolol. 2010.

Tang S.C.W., Lin M., Tam S., Au W.S., Ma M.K., Yap D.Y., Ho Y.W. and Lai K.N., Aliskiren combined with losartan in immunoglobulin A nephropathy: an open-labeled pilot study, Nephrology Dialysis Transplantation. 2011.

Yap D.Y., Chu F.S.K., Chu S.S.M., Tam P.C., Tam S., Chan D.T.M., Lai K.N. and Tang S.C.W., CT angiography versus conventional digital angiography in preoperative assessment for Chinese living kidney donors, Journal of Nephrology. 2010, 23(6): 711-6.

Researcher : Tang KH

List of Research Outputs

Lee K.W., Castilho A.G., Cheung C.H., Tang K.H., Ma S.K.Y. and Ng I.O.L., CD24+ liver tumor initiating cells drive self-renewal and tumor initiation through Stat3- mediated Nanog regulation, AACR 102nd Annual meddting 2011.

Lee K.W., Castilho A.G., Cheung C.H., Tang K.H., Ma S.K.Y. and Ng I.O.L., Lupeol targets liver tumor initiating cells through PTEN modulation, Hepatology. 2011, 53: 160-70.

Ma S.K.Y., Kwan P.S., Chan Y.P., Fu L., Tang K.H., Tong M., Chan K.W. and Guan X., RNA-Seq identifies protein tyrosine kinase 6 (PTK6) as a candidate tumor-suppressor gene in esophageal squamous cell carcinoma , American Association for Cancer Research - Annual Meeting 2011.

Ma S.K.Y., Tang K.H., Chan Y.P., Lee K.W., Kwan P.S., Castilho A.G., Ng I.O.L., Man K., Wong N., To K.F., Zheng B., Lai P.B.S., Lo C.M., Chan K.W. and Guan X.Y., miR-130b promotes CD133(+) liver tumor-initiating cell growth and self-renewal via tumor protein 53-induced nuclear protein 1, Cell Stem Cell. 2010, 7(6): 694-707.

Ma S.K.Y., Chan Y.P., Kwan P.S., Lee K.W., Yan M., Tang K.H., Ling M.T., Vielkind J.R., Guan X. and Chan K.W., microRNA-616 induces androgen-independent growth of prostate cancer cells by suppressing expression of tissue factor pathway inhibitor TFPI-2, Cancer Research. 2011, 71: 583-92.

Tang K.H., Ma S.K.Y., Kwan P.S., Chan Y.P., Lee K.W., Ng I.O.L., Guan X. and Chan K.W., CD133+ liver tumor-initiating cells promote tumor growth, angiogenesis and self-renewal through activation of the neurotensin / interleukin-8 signaling cascade, American Association for Cancer Reseach - Annual Meeting 2011.

Tong M., Tang K.H., Guan X. and Ma S.K.Y., Loss of Rab25 Expression Promotes Tumor Formation and Angiogenesis in Esophageal Squamous Cell Carcinoma , American Association for Cancer Research - Annual Meeting 2011.

Researcher : Tang KH

List of Research Outputs

Lee K.W., Castilho A.G., Cheung C.H., Tang K.H., Ma S.K.Y. and Ng I.O.L., Lupeol targets liver tumor initiating cells through PTEN modulation, Hepatology. 2011, 53: 160-70.

Researcher : Tao Q

List of Research Outputs

Cheng Y., Geng H., Cheng S.H., Liang P., Bai Y., Li J., Srivastava G., Ng M.H., Fukagawa T., Wu X., Chan A.T. and Tao Q., KRAB Zinc Finger Protein ZNF382 Is a Proapoptotic Tumor Suppressor That Represses Multiple Oncogenes and Is Commonly Silenced in Multiple Carcinomas, Cancer Res. 2010, 70(16): 6516-26.

Li J., Ying J., Fan Y., Wu L., Ying Y., Chan A.T., Srivastava G. and Tao Q., WNT5A antagonizes WNT/beta-catenin signaling and is frequently silenced by promoter CpG methylation in esophageal squamous cell carcinoma, Cancer Biol Ther. 2010, 10(6).

Researcher : Tin P.C.

List of Research Outputs

Wong W...S..., Leung L...H..., Wong K.M., Tin P...C... and Wong M...P..., A novel KIF5B-ALK fusion gene variant with transforming potentials in non-small cell lung cancer, 102nd American Association for Cancer Research meeting, Orlando, U.S., April 2011 . 2011.

Researcher : Tin PC

List of Research Outputs

Leung L.H., Fiscus R.R., Tung J.W., Tin P.C., Cheng L.C., Sihoe A.D.L., Fink L.M., Ma Y. and Wong M.P., Non-small cell lung cancer cells expressing CD44 are enriched for stem cell-like properties, PLoS One. 2010, 5(11): e14062.

Wong D.W., Leung L.H., Wong K.M., Tin P.C., Sihoe A.D., Cheng L.C., Au J.S., Chung L.P. and Wong M.P., A novel KIF5B-ALK variant in nonsmall cell lung cancer, Cancer. 2011, 117(12): 2709-18.

Wong K.M., Leung L.H., Tin P.C. and Wong M.P., Non-small cell lung cancer cells with high aldehyde dehydrogenase 1 activity display cancer stem cell properties and show chemoresistance, 102nd American Association for Cancer Research meeting, Orlando, U.S., 3 April 2011.

Researcher : Tong M

List of Research Outputs

Ma S.K.Y., Kwan P.S., Chan Y.P., Fu L., Tang K.H., Tong M., Chan K.W. and Guan X., RNA-Seq identifies protein tyrosine kinase 6 (PTK6) as a candidate tumor-suppressor gene in esophageal squamous cell carcinoma , American Association for Cancer Research - Annual Meeting 2011.

Tong M., Tang K.H., Guan X. and Ma S.K.Y., Loss of Rab25 Expression Promotes Tumor Formation and Angiogenesis in Esophageal Squamous Cell Carcinoma , American Association for Cancer Research - Annual Meeting 2011.

Researcher : Tong SF

List of Research Outputs

Lam C.W., Lau K.C. and Tong S.F., Microarrays for personalized genomic medicine, Advances in Clinical Chemistry. 2010, 52: 1-18.

Siu C.W.K., Ma R.C., Lam C.W., Mak C.M., Yuen L.Y.P., Lo F.M., Chan K.W., Lam S.F., Ling S.C., Tong S.F., So W.Y., Chow C.C., Tang M.H., Tam W.H. and Chan A.Y.W., Molecular basis of von Hippel-Lindau syndrome in Chinese patients, Chinese Medical Journal (English Version). 2011, 124(2): 237-41.

Wong W.C., Lam C.W., Tong S.F. and Tong C.T., Persistent hypocalcaemia in a Chinese girl due to a novel de-novo activating mutation of the calcium-sensing receptor gene, Hong Kong Medical Journal. 2011, 17(2): 157-60.

Researcher : Tsang STY

List of Research Outputs

Tsang S.T.Y. and So J.C.C., Role of Chromosomal 6q23 Region in the Modulation of HbF Production, 17th Hemoglobin Switching Conference, 2-5 September 2010, St. John’s College, Oxford, UK. 2010.

Researcher : Tse YT

List of Research Outputs

Tse Y.T. and Yam J.W.P., Signaling pathways in hepatocellular carcinoma, In: Benjamin J. Valverde, Liver Cancer: Causes, Diagnosis and Treatment. Nova Science, 2011.

Wong Y.S.S., Tse Y.T. and Yam J.W.P., Role of hypoxia-induced upregulation of Caveolin-1 in hepatocellular carcinoma cell migration and invasion, The 102st American Association for Cancer Research Annual Meeting, Orlando, Florida, USA. 2011.

Researcher : Tsui YM

List of Research Outputs

Tsui Y.M., Tung K.K., Mak K.M. and Ng I.O.L., Dishevelled 3 (Dvl3) is upregulated and enhances cell migration and invasion in hepatocellular carcinoma , American Association for Cancer Research 102nd Annual Meeting 2011.

Researcher : Tung KK

Project Title:	Characterization of Prickle2 in liver cancer
Investigator(s):	Tung KK, Ng IOL
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	12/2010

List of Research Outputs

Gao P., Wong C.C.L., Tung K.K., Lee M.F., Wong C.M. and Ng I.O.L., Deregulation of microRNA expression occurs early and accumulates in early stages of HBV-associated multistep hepatocarcinogenesis., Journal of Hepatology. Elsevier B.V., 2011, 54: 1177-1184.

Ko F.C.F., Chan L.K., Tung K.K., Scott S.W., Ng I.O.L. and Yam J.W.P., Akt phosphorylation of deleted in liver cancer 1 abrogates its suppression of liver cancer tumorigenesis and metastasis., Gastroenterology. Elsevier Inc., 2010, 139: 1397-1407.e6.

Lo C.L.R., Tung K.K., Mak K.M., Fatima S., Zhou H., Poon R.T.P., Yuen R.M.F., Lai C.L., Li J., Luk J.M.C. and Ng I.O.L., Both tissue and serum dickkopf-1 (DKK-1) levels have clincopathologic and prognostic significance in hepatocellular carcinoma., Hepatology . 2010, 52(4 Suppl): 282A.

Tsui Y.M., Tung K.K., Mak K.M. and Ng I.O.L., Dishevelled 3 (Dvl3) is upregulated and enhances cell migration and invasion in hepatocellular carcinoma , American Association for Cancer Research 102nd Annual Meeting 2011.

Wong C.C.L., Wong C.M., Tung K.K., Au L.K., Lee M.F., Poon R.T.P., Man K. and Ng I.O.L., The microRNA miR-139 suppresses metastasis and progression of hepatocellular carcinoma by down-regulating Rho-kinase 2, Gastroenterology. 2011, 140(1): 322-331.

Wong C.M., Wong C.C.L., Tung K.K., Au L.K., Lee M.F., Man K. and Ng I.O.L., MiR-139 suppresses metastasis and progression of hepatocellular carcinoma through regulation of Rho-Kinase 2 (ROCK2), International Liver Cancer Association Fourth Annual Conference . Montreal, QC, Canada, 2010.

Researcher : Walther TJ

List of Research Outputs

Nicholls J.M., Chan W.Y., Li C.L., Walther T.J. and Haslam S.T.U.A.R.T., Receptors in the Human Respiratory Tract - Making and Breaking the Links, Keystone Symposia on Molecular and Cellular Biology: Pathogenesis of Influenza: virus-host interactions. 2011.

Researcher : Wan TSK

List of Research Outputs

Zhu M., Wang N., Tsao G.S.W., Yuen R.M.F., Feng Y.G., Wan T.S.K., Man K. and Feng Y., Up-regulation of microRNAs, miR21 and miR23a, in human liver cancer cells treated with Coptidis Rhizome aqueous extract, Experimental and Therapeutic Medicine. 2011.

Researcher : Wei L

List of Research Outputs

Wei L., Liu J., Le X.C., Han Y., Tong Y., Lau A.S.Y. and Rong J., Pharmacological induction of leukotriene B4-12-hydroxydehydrogenase suppresses the oncogenic transformation of human hepatoma HepG2 cells, International Journal of Oncology. Athens, Greece, Spandidos Publications Ltd, 2011, 39: 735-745.

Researcher : Wong ACN

List of Research Outputs

Yuen K.M., Chan W.Y., Mok K.P., Wong A.C.N., Kang S.R., Nicholls J.M. and Chan M.C.W., Differential onset of apoptosis in avian influenza H5N1 and seasonal H1N1 virus infected human bronchial and alveolar epithelial cell, an in vitro and ex vivo study, Options for the Control of Influenza VII. 2010.

Researcher : Wong CCL

List of Research Outputs

Gao P., Wong C.C.L., Tung K.K., Lee M.F., Wong C.M. and Ng I.O.L., Deregulation of microRNA expression occurs early and accumulates in early stages of HBV-associated multistep hepatocarcinogenesis., Journal of Hepatology. Elsevier B.V., 2011, 54: 1177-1184.

Wong C.C.L., Wong C.M., Tung K.K., Au L.K., Lee M.F., Poon R.T.P., Man K. and Ng I.O.L., The microRNA miR-139 suppresses metastasis and progression of hepatocellular carcinoma by down-regulating Rho-kinase 2, Gastroenterology. 2011, 140(1): 322-331.

Wong C.M., Wong C.C.L., Tung K.K., Au L.K., Lee M.F., Man K. and Ng I.O.L., MiR-139 suppresses metastasis and progression of hepatocellular carcinoma through regulation of Rho-Kinase 2 (ROCK2), International Liver Cancer Association Fourth Annual Conference . Montreal, QC, Canada, 2010.

Wong C.M., Wong C.C.L., Ng Y.L., Au L.K., Ko F.C.F. and Ng I.O.L., Transcriptional repressive H3K9 and H3K27 methylations contribute to DNMT1-mediated DNA methylation recovery, American Association for Cancer Research (AACR) 102 st Annual meeting 2011.

Researcher : Wong CM

Project Title:	Roles of histone methyltransferases SUV39H1 and SUV39H2 in liver cancer
Investigator(s):	Wong CM, Ng IOL
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2008

Project Title:	Functional and pathological implications of EZH2 in human HCC
Investigator(s):	Wong CM, Ng IOL
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2009
Completion Date:	01/2011

Project Title:	Epigenetic alteration and miRNA deregulation in liver cancer
Investigator(s):	Wong CM, Ng IOL
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2010

Project Title:	Characterization of EZH2 mediated miRNA deregulation in liver cancer
Investigator(s):	Wong CM, Ng IOL
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2011

Project Title:	102nd American Association for Cancer Resarch (AACR) Annual Meeting Transcriptional repressive H3K9 and H3K27 methylations are essential for DNMT1-mediated DNA methylation recovery
Investigator(s):	Wong CM
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Grants for Teaching Staff
Start Date:	04/2011
Completion Date:	04/2011

List of Research Outputs

Gao P., Wong C.C.L., Tung K.K., Lee M.F., Wong C.M. and Ng I.O.L., Deregulation of microRNA expression occurs early and accumulates in early stages of HBV-associated multistep hepatocarcinogenesis., Journal of Hepatology. Elsevier B.V., 2011, 54: 1177-1184.

Liang L., Wong C.M., Ying Q., Fan N.Y., Huang S., Ding J., Yao J., Yan M., Li J., Yao M., Ng I.O.L. and He X., MicroRNA-125b suppressesed human liver cancer cell proliferation and metastasis by directly targeting oncogene LIN28B2, Hepatology. 2010, 52: 1731-40.

Wong C.C.L., Wong C.M., Tung K.K., Au L.K., Lee M.F., Poon R.T.P., Man K. and Ng I.O.L., The microRNA miR-139 suppresses metastasis and progression of hepatocellular carcinoma by down-regulating Rho-kinase 2, Gastroenterology. 2011, 140(1): 322-331.

Wong C.M., Wong C.C.L., Tung K.K., Au L.K., Lee M.F., Man K. and Ng I.O.L., MiR-139 suppresses metastasis and progression of hepatocellular carcinoma through regulation of Rho-Kinase 2 (ROCK2), International Liver Cancer Association Fourth Annual Conference . Montreal, QC, Canada, 2010.

Wong C.M. and Ng I.O.L., Molecular Pathogenesis of Hepatocellular, In: Wang, Xin Wei; Grisham, Joe W.; Thorgeirsson, Snorri S, Molecular Genetics of Liver Neoplasia. Springer, 2011, 373-396.

Wong C.M., Wong C.C.L., Ng Y.L., Au L.K., Ko F.C.F. and Ng I.O.L., Transcriptional repressive H3K9 and H3K27 methylations contribute to DNMT1-mediated DNA methylation recovery, American Association for Cancer Research (AACR) 102 st Annual meeting 2011.

Yang J., Yang W., Hirankarn N., Ye D.Q., Zhang Y., Pan H.F., Mok C.C., Chan T.M., Wong R.W.S., Mok M.Y., Lee K.W., Wong S.N., Leung A.M.H., Li X.P., Avihingsanon Y., Rianthavorn P., Deekajorndej T., Suphapeetiporn K., Shotelersuk V., Baum L., Kwan P., Lee T.L., Ho M.H.K., Lee P.P.W., Wong W.H.S., Zeng S., Zhang J., Wong C.M., Ng I.O.L., Garcia-Barcelo M.M., Cherny S.S., Tam P.K.H., Sham P.C., Lau W.C.S. and Lau Y.L., ELF1 is associated with systemic lupus erythematosus in Asian populations, Human Molecular Genetics. 2011, 20(3): 601-607.

Zhang Y., Yang W., Mok C.C., Chan T.M., Wong R.W.S., Mok T.M.Y., Lee K.W., Wong S.N., Leung A.M.H., Lee T.L., Ho M.H.K., Lee P.P.W., Wong W.H.S., Yang J., Zhang J., Wong C.M., Ng I.O.L., Garcia-Barcelo M.M., Cherny S.S., Tam P.K.H., Sham P.C., Lau W.C.S. and Lau Y.L., Two missense variants in UHRF1BP1 are indpendently associated with systemic lupus erythematosus in Hong Kong Chinese, Genes and Immunity. 2011, 12(3): 231-234.

Researcher : Wong CN

List of Research Outputs

Yuen K.M., Chan W.Y., Mok K.P., Wong C.N., Kang S.R., Nicholls J.M. and Chan M.C.W., Differential onset of apoptosis in avian influenza H5N1 and seasonal H1N1 virus infected human bronchial and alveolar epithelial cells: an in vitro and ex vivo study, Influenza and other respiratory viruses. 2011, 5 (S1): 437-438.

Researcher : Wong ESY

List of Research Outputs

Cheung A.N.Y., Wong G.W., Yang M.S., Tsang C.H., Ji S.L., Szeto E.F., Wong E.S.Y. and Ngan H.Y.S., Microarray-in-microwell HPV Profiling of Atypical Squamous cells of Undetermined Significance in an Asian Screening Population , 26th International Papillomavirus Conference, Montreal, Canada. 2010.

Mak C.Y., Siu K.Y., Wong G.W., Ngan H.Y.S., Wong E.S.Y. and Cheung A.N.Y., Downregulation of ASPP1 in gestational trophoblastic disease: correlation with hypermethylation, apoptotic activity and clinical outcome., Modern pathology. 2011, 24: 522-532.

Siu K.Y., Wong E.S.Y., Chan H.Y., Kong S.H., Woo N.W., Tam K.F., Ngan H.Y.S., Chan Q.K.Y., Chan D.C., Chan Y.K. and Cheung A.N.Y., Differential expression and phosphorylation of Pak1 and Pak2 in ovarian cancer: effects on prognosis and cell invasion, International Journal of Cancer. 2010.

Siu K.Y., Chan H.Y., Kong S.H., Wong E.S.Y., Wong G.W., Ngan H.Y.S., Tam K.F., Tsao G.S.W. and Cheung A.N.Y., p21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients., Proceedings of the National Academy of Sciences of the United States of America . 2010, 107: 18622-18627.

Researcher : Wong GW

Project Title:	Role of Plexin-B1 signaling in ovarian cancer
Investigator(s):	Wong GW, Siu KY
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2010
Completion Date:	06/2011

List of Research Outputs

Cheung A.N.Y., Wong G.W., Yang M.S., Tsang C.H., Ji S.L., Szeto E.F., Wong E.S.Y. and Ngan H.Y.S., Microarray-in-microwell HPV Profiling of Atypical Squamous cells of Undetermined Significance in an Asian Screening Population , 26th International Papillomavirus Conference, Montreal, Canada. 2010.

Jiang L., Siu K.Y., Wong G.W., Tam K.F., Ngan H.Y.S., Wong S.Y., Chan H.Y. and Cheung A.N.Y., Overexpression of proto-oncogene FBI-1 activates membrane type 1-matrix metalloproteinase in association with adverse outcome in ovarian cancers., Molecular cancer. 2010, 9: 318.

Mak C.Y., Siu K.Y., Wong G.W., Ngan H.Y.S., Wong E.S.Y. and Cheung A.N.Y., Downregulation of ASPP1 in gestational trophoblastic disease: correlation with hypermethylation, apoptotic activity and clinical outcome., Modern pathology. 2011, 24: 522-532.

Siu K.Y., Chan H.Y., Kong S.H., Wong E.S.Y., Wong G.W., Ngan H.Y.S., Tam K.F., Tsao G.S.W. and Cheung A.N.Y., p21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients., Proceedings of the National Academy of Sciences of the United States of America . 2010, 107: 18622-18627.

Siu K.Y., Chan H.Y., Kong S.H., Wong S.Y., Wong G.W., Ngan H.Y.S., Tam K.F., Zhang H., Li Z., Chan Q.K.Y., Tsao G.S.W., Strömblad S. and Cheung A.N.Y., p21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients, PNAS. 2010, 107(43): 18622-18627.

Wong G.W., Lo C.K., Szeto E.F. and Cheung A.N.Y., Efficacy of Abbott RealTime High Risk HPV test in evaluation of atypical squamous cells of undetermined significance from an Asian screening population., Journal of Clinical Virology. 2011, 51: 136-138.

Zhang H., Siu K.Y., Jiang L., Mak C.Y., Ngan H.Y.S., Wong G.W. and Cheung A.N.Y., Overexpressed PAK4 promotes proliferation, migration and invasion of choriocarcinoma., Carcinogenesis. 2011, 32: 765-771.

Researcher : Wong KM

List of Research Outputs

Wong D.W., Leung L.H., Wong K.M., Tin P.C., Sihoe A.D., Cheng L.C., Au J.S., Chung L.P. and Wong M.P., A novel KIF5B-ALK variant in nonsmall cell lung cancer, Cancer. 2011, 117(12): 2709-18.

Wong K.M., Leung L.H., Tin P.C. and Wong M.P., Non-small cell lung cancer cells with high aldehyde dehydrogenase 1 activity display cancer stem cell properties and show chemoresistance, 102nd American Association for Cancer Research meeting, Orlando, U.S., 3 April 2011.

Wong W...S..., Leung L...H..., Wong K.M., Tin P...C... and Wong M...P..., A novel KIF5B-ALK fusion gene variant with transforming potentials in non-small cell lung cancer, 102nd American Association for Cancer Research meeting, Orlando, U.S., April 2011 . 2011.

Researcher : Wong KM

List of Research Outputs

Wong D.W., Leung L.H., Wong K.M., Tin P.C., Sihoe A.D., Cheng L.C., Au J.S., Chung L.P. and Wong M.P., A novel KIF5B-ALK variant in nonsmall cell lung cancer, Cancer. 2011, 117(12): 2709-18.

Researcher : Wong LT

List of Research Outputs

Sze M.F., Wong L.T., Chu K.Y., Lee M.F., Yau T.O. and Ng I.O.L., Loss of phosphatase and tensin homolog enhances cell invasion and migration through AKT/Sp-1 transcription factor/matrix metalloproteinase 2 activation in hepatocellular carcinoma and has clinicopathologic significance, In: Keith D. Lindor, Hepatology. 2011, 53 Issue 5: 1558-1569.

Researcher : Wong M.P.

Project Title:	Mutational Analysis of Epidermal Growth Factor Receptor in Non-Small Cell Lung Cancer
Investigator(s):	Wong MP, Chua DTT
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2005

Project Title:	ALK fusion genes in non-small cell lung cancer
Investigator(s):	Wong MP, Leung LH
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2008
Completion Date:	10/2010

Project Title:	Cancer genes alterations and their biological effects in lung cancer
Investigator(s):	Wong MP, Leung LH
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2008
Completion Date:	05/2011

Project Title:	Generation of a versatile and inducible EGFRL858R mouse lung cancer model and its application for studying gene collaboration in lung carcinogenesis
Investigator(s):	Wong MP, Leung LH, Cai K
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2010

Project Title:	p38 MAPK in human lung cancers and its potential involvement in treatment resistance to tyrosine kinase inhibitors
Investigator(s):	Wong MP, Cai K
Department:	Pathology
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2011

Project Title:	p38 MAPK in human lung cancers and its involvement in treatment resistance to tyrosine kinase inhibitors
Investigator(s):	Wong MP, Leung LH
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	02/2011

Project Title:	AACR 102nd Annual Meeting 2011 A novel KIF5B-ALK fusion gene variant with transforming potentials in non-small cell lung cancer
Investigator(s):	Wong MP
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Grants for Teaching Staff
Start Date:	04/2011
Completion Date:	04/2011

List of Research Outputs

Wong W...S..., Leung L...H..., Wong K.M., Tin P...C... and Wong M...P..., A novel KIF5B-ALK fusion gene variant with transforming potentials in non-small cell lung cancer, 102nd American Association for Cancer Research meeting, Orlando, U.S., April 2011 . 2011.

Researcher : Wong MLY

List of Research Outputs

Yuen H.F., McCrudden C.M., Chan K.K., Chan Y.P., Wong M.L.Y., Chan Y.K., Khoo U.S., Law S., Srivastava G., Lappin T.R., Chan K.W. and El-Tanani M., The role of pea3 group transcription factors in esophageal squamous cell carcinoma, Am J Pathol. 2011, 179 (2): 992-1003.

Researcher : Wong MP

Project Title:	Mutational Analysis of Epidermal Growth Factor Receptor in Non-Small Cell Lung Cancer
Investigator(s):	Wong MP, Chua DTT
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2005

Project Title:	ALK fusion genes in non-small cell lung cancer
Investigator(s):	Wong MP, Leung LH
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2008
Completion Date:	10/2010

Project Title:	Cancer genes alterations and their biological effects in lung cancer
Investigator(s):	Wong MP, Leung LH
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2008
Completion Date:	05/2011

Project Title:	Generation of a versatile and inducible EGFRL858R mouse lung cancer model and its application for studying gene collaboration in lung carcinogenesis
Investigator(s):	Wong MP, Leung LH, Cai K
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2010

Project Title:	p38 MAPK in human lung cancers and its potential involvement in treatment resistance to tyrosine kinase inhibitors
Investigator(s):	Wong MP, Cai K
Department:	Pathology
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2011

Project Title:	p38 MAPK in human lung cancers and its involvement in treatment resistance to tyrosine kinase inhibitors
Investigator(s):	Wong MP, Leung LH
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	02/2011

Project Title:	AACR 102nd Annual Meeting 2011 A novel KIF5B-ALK fusion gene variant with transforming potentials in non-small cell lung cancer
Investigator(s):	Wong MP
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Grants for Teaching Staff
Start Date:	04/2011
Completion Date:	04/2011

List of Research Outputs

Leung L.H., Fiscus R.R., Tung J.W., Tin P.C., Cheng L.C., Sihoe A.D.L., Fink L.M., Ma Y. and Wong M.P., Non-small cell lung cancer cells expressing CD44 are enriched for stem cell-like properties, PLoS One. 2010, 5(11): e14062.

Sihoe A.D., Yeung E.S., Cheng L.C., Wang E. and Wong M.P., LYMPH NODE EVALUATION DURING LOBECTOMY FOR LUNG CANCER: COMPLETE VIDEO ASSISTED THORACIC SURGERY VERSUS OPEN SURGERY, Asian Cardiovascular Thoracic Surgeons, Phuket, Thailand, 26-29 May 2011.. 2011.

Wong D.W., Leung L.H., Wong K.M., Tin P.C., Sihoe A.D., Cheng L.C., Au J.S., Chung L.P. and Wong M.P., A novel KIF5B-ALK variant in nonsmall cell lung cancer, Cancer. 2011, 117(12): 2709-18.

Wong K.M., Leung L.H., Tin P.C. and Wong M.P., Non-small cell lung cancer cells with high aldehyde dehydrogenase 1 activity display cancer stem cell properties and show chemoresistance, 102nd American Association for Cancer Research meeting, Orlando, U.S., 3 April 2011.

Wong M.P., Lung Cancers In Non-smokers - An Evolving Story , Hong Kong International Cancer Congress. 2010.

Researcher : Wong SY

List of Research Outputs

Chen J., Gomes A.R., Monteiro L.J., Wong S.Y., Wu L.H., Ng T.T., Karadedou C.T., Millour J., Ip Y.C., Cheung Y.N., Sunters A., Chan Y.K., Lam E.W. and Khoo U.S., Constitutively nuclear FOXO3a localization predicts poor survival and promotes Akt phosphorylation in breast cancer, PLoS One. 2010, 5(8): e12293.

Jiang L., Siu K.Y., Wong G.W., Tam K.F., Ngan H.Y.S., Wong S.Y., Chan H.Y. and Cheung A.N.Y., Overexpression of proto-oncogene FBI-1 activates membrane type 1-matrix metalloproteinase in association with adverse outcome in ovarian cancers., Molecular cancer. 2010, 9: 318.

Siu K.Y., Chan H.Y., Kong S.H., Wong S.Y., Wong G.W., Ngan H.Y.S., Tam K.F., Zhang H., Li Z., Chan Q.K.Y., Tsao G.S.W., Strömblad S. and Cheung A.N.Y., p21-activated kinase 4 regulates ovarian cancer cell proliferation, migration, and invasion and contributes to poor prognosis in patients, PNAS. 2010, 107(43): 18622-18627.

Yuen H.F., Chan Y.K., Grills C., McCrudden C.M., Gunasekharan V., Shi Z., Wong S.Y., Lappin T.R., Chan K.W., Fennell D.A., Khoo U.S., Johnston P.G. and El-Tanani M., Polyomavirus enhancer activator 3 protein promotes breast cancer metastatic progression through Snail-induced epithelial-mesenchymal transition, J Pathol. 2011, 224(1): 78-89.

Researcher : Wong W.S.

List of Research Outputs

Wong W...S..., Leung L...H..., Wong K.M., Tin P...C... and Wong M...P..., A novel KIF5B-ALK fusion gene variant with transforming potentials in non-small cell lung cancer, 102nd American Association for Cancer Research meeting, Orlando, U.S., April 2011 . 2011.

Researcher : Wong YSS

List of Research Outputs

Wong Y.S.S., Tse Y.T. and Yam J.W.P., Role of hypoxia-induced upregulation of Caveolin-1 in hepatocellular carcinoma cell migration and invasion, The 102st American Association for Cancer Research Annual Meeting, Orlando, Florida, USA. 2011.

Researcher : Xu M

List of Research Outputs

Chan Y.K., Xu M., Ching J.C.Y., Chan V.S.F., Ip Y.C., Yam L., Chu C.M., Lai S.T., So K.M., Wong T.Y., Chung P.H., Tam P., Yip S.P., Sham P.C., Lin C., Leung G.M., Peiris J.S.M. and Khoo U.S., Association of a single nucleotide polymorphism in the CD209 (DC-SIGN) promoter with SARS severity, Hong Kong Med J. 2010, 16(5 Suppl 4): 37-42.

Khoo U.S., Ching J.C.Y., Chan Y.K., Xu M., So K.M., Lai S.T., Chu C.M., Yam L., Wong T.Y., Chung P.H., Chan V.S.F., Tam P.K.H., Yip S.P., Lin C.L., Sham P.C., Leung G.M. and Peiris J.S.M., The CD209 (DC-SIGN) -336A>G and MxA -123C>A promoter polymorphisms in Severe Acute Respiratory Syndrome Coronavirus infection in Hong Kong Chinese, Health Research Symposium 2010: “Improving health and recognising excellence, Hong Kong. 2010.

Researcher : Xu MS

List of Research Outputs

Chan Y.K., Xu M.S., Ching C.Y.J., So T.M., Lai S.T., Chu C.M., Yam L.Y., Wong A.T., Chung P.H., Chan V.S.F., Lin C.L., Sham P.C., Leung G.M., Peiris J.S.M. and Khoo U.S., CD209 (DC-SIGN) -336A>G promoter polymorphism and severe acute respiratory syndrome in Hong Kong Chinese, Hum Immunol. 2010, 71(7): 702-7.

Researcher : Yam JWP

Project Title:	Nucleocytoplasmic shuttling mechanism of DLC1 tumor suppressor in liver cancer
Investigator(s):	Yam JWP, Ng IOL
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2008
Completion Date:	06/2011

Project Title:	Significance and transcriptional upregulation of caveolin-1 by PPARγ in liver cancer metastasis
Investigator(s):	Yam JWP, Ng IOL
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2009
Completion Date:	05/2011

Project Title:	Outstanding Young Researcher Award 2008-2009
Investigator(s):	Yam JWP
Department:	Pathology
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	12/2009

Project Title:	Role of caveolin-1 in liver cancer metastasis through HGF/Met signaling pathway
Investigator(s):	Yam JWP, Wong AST
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2010

Project Title:	BIT's 1st World Congress of Virus and Infections 2010 Role of focal adhesion proteins in hepatocellular carcinoma
Investigator(s):	Yam JWP
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Grants for Teaching Staff
Start Date:	07/2010
Completion Date:	08/2010

Project Title:	Interplay of caveolin-1 and met receptor in liver cancer metastasis
Investigator(s):	Yam JWP, Wong AST
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2011

Project Title:	Impact of nuclear translocation of Met receptor in liver cancer progression
Investigator(s):	Yam JWP, Wong AST
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2011

List of Research Outputs

Chan J., Ko F.C.F., Ng I.O.L. and Yam J.W.P., Integrin-linked kinase overexpression and its oncogenic role in promoting tumorigenicity of hepatocellular carcinoma, PLoS ONE. 2011, 6(2): e16984.

Ko F.C.F., Chan L.K., Tung K.K., Scott S.W., Ng I.O.L. and Yam J.W.P., Akt phosphorylation of deleted in liver cancer 1 abrogates its suppression of liver cancer tumorigenesis and metastasis., Gastroenterology. Elsevier Inc., 2010, 139: 1397-1407.e6.

Ko F.C.F., Ng I.O.L. and Yam J.W.P., DLC1 (deleted in liver cancer 1), Atlas of Genetics and Cytogenetics in Oncology and Haematology. 2010.

Ko F.C.F., Chan L.K., Ng I.O.L. and Yam J.W.P., PKA Phosphorylation of Deleted in Liver Cancer 1 (DLC1) at serine-549 modulates its inhibitory activity in liver cancer tumourigenesis, The 3rd JCA-AACR Special Joint Conference, Chiba, Japan. 2011.

Tse Y.T. and Yam J.W.P., Signaling pathways in hepatocellular carcinoma, In: Benjamin J. Valverde, Liver Cancer: Causes, Diagnosis and Treatment. Nova Science, 2011.

Wong Y.S.S., Tse Y.T. and Yam J.W.P., Role of hypoxia-induced upregulation of Caveolin-1 in hepatocellular carcinoma cell migration and invasion, The 102st American Association for Cancer Research Annual Meeting, Orlando, Florida, USA. 2011.

Yam J.W.P., Grant reviewer, Medical Research Council – New Investigator Research Grant. 2010.

Yam J.W.P., Phosphorylation of DLC1 tumor suppressor: its functional impact, Frontiers in Biomedical Research. 2010.

Yam J.W.P., Phosphorylation of DLC1 tumor suppressor: its functional impact, Hubei University of Medicine, Institute of Basic Medical Sciences. 2011.

Yam J.W.P., Reviewer, Current Cancer Drug Targets. 2011.

Yam J.W.P., Reviewer, The Journal of Clinical Investigation. 2011.

Yam J.W.P., Role of focal adhesion proteins in hepatocellular carcinoma, BIT Life Sciences’ 1st World Congress of Virus and Infections. 2010.

Yam J.W.P., Session co-chair, BIT Life Sciences’ 1st World Congress of Virus and Infections-2010 (WCVI-2010). 2010.

Researcher : Yang M

List of Research Outputs

Lu L. and Yang M., Novel function of BAFF in the induction of IL-10-producing regulatory B cells, The 14th International Congress of Immunology, Kansai, Japan. 2010.

Ma J., Wang S., Ma B., Mao C., Tong J., Yang M., Wu C., Jiao Z., Lu L. and Xu H., Dendritic cells engineered to express GITRL enhance therapeutic immunity in murine Lewis lung carcinoma, Cancer Lett. 2011, 301(2): 142-50.

Yao H., Ng S.S., Huo L.F., Chow B.K., Shen Z., Yang M., Sze J., Ko O., Li M., Yue A., Lu L., Bian X.W., Kung H.F. and Lin M.C., Effective melanoma immunotherapy with interleukin-2 delivered by a novel polymeric nanoparticle., Mol Cancer Ther. 2011, 10(6): 1082-92.

Researcher : Yau TO

Project Title:	The role of Frizzled-7, receptor of the WNT/β-catenin signalling pathway, in hepatocellular carcinoma: Implications in tumorigenesis and metastasis
Investigator(s):	Yau TO, Ng IOL
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	10/2006

List of Research Outputs

Mak W.Y.G., Chan M.L., Leong V.Y.L., Lee M.F., Yau T.O., Ng I.O.L. and Ching Y.P., Overexpression of a novel activator of PAK4, the CDK5 kinase-associated protein CDK5RAP3, promotes hepatocellular carcinoma metastasis, Cancer Research. 2011, 71: 2949-58.

Sze M.F., Wong L.T., Chu K.Y., Lee M.F., Yau T.O. and Ng I.O.L., Loss of phosphatase and tensin homolog enhances cell invasion and migration through AKT/Sp-1 transcription factor/matrix metalloproteinase 2 activation in hepatocellular carcinoma and has clinicopathologic significance, In: Keith D. Lindor, Hepatology. 2011, 53 Issue 5: 1558-1569.

Researcher : Yip SF

List of Research Outputs

Leung T.W., Yip S.F., Lam C.W., Chan T.L., Lam W.W., Siu D.Y., Fan Y.H., Chan N.P., Liu H.S., Chan L.C. and Wong K.S., Genetic predisposition of white matter infarction with protein S deficiency and R355C mutation, Neurology. 2010, 75(24): 2185-9.

So J.C.C., Leung R.Y.Y., Yip S.F., Chan S.Y., Lam C.C.K., Chan G.C.F., Chim S. and Chan L.C., Common association of haemolytic uraemic syndrome with invasive Streptococcus pneumoniae infection in five Chinese paediatric patients, Hong Kong Med J. 2011, 17(3): 237-41.

So J.C.C., Chan A.Y.Y., Chow E.Y.D., Lin S.Y., Yip S.F., Szeto S.C. and Chan L.C., Haemoglobin Bonn in a Chinese family as a cause of spurious hypoxaemia measured by pulse oximetry, J Clin Pathol. 2010, 63(10): 947-9.

Researcher : Yip SP

List of Research Outputs

Chan Y.K., Xu M., Ching J.C.Y., Chan V.S.F., Ip Y.C., Yam L., Chu C.M., Lai S.T., So K.M., Wong T.Y., Chung P.H., Tam P., Yip S.P., Sham P.C., Lin C., Leung G.M., Peiris J.S.M. and Khoo U.S., Association of a single nucleotide polymorphism in the CD209 (DC-SIGN) promoter with SARS severity, Hong Kong Med J. 2010, 16(5 Suppl 4): 37-42.

Khoo U.S., Ching J.C.Y., Chan Y.K., Xu M., So K.M., Lai S.T., Chu C.M., Yam L., Wong T.Y., Chung P.H., Chan V.S.F., Tam P.K.H., Yip S.P., Lin C.L., Sham P.C., Leung G.M. and Peiris J.S.M., The CD209 (DC-SIGN) -336A>G and MxA -123C>A promoter polymorphisms in Severe Acute Respiratory Syndrome Coronavirus infection in Hong Kong Chinese, Health Research Symposium 2010: “Improving health and recognising excellence, Hong Kong. 2010.

Researcher : Yuen HF

List of Research Outputs

Chua C.W., Chiu Y.T., Yuen H.F., Chan K.W., Wang X., Ling M.T. and Wong Y.C., Differential expression of MSX2 in nodular hyperplasia, high-grade prostatic intraepithelial neoplasia and prostate adenocarcinoma, APMIS. 2010, 118(12): 918-26.

Yuen H.F., Chan Y.K., Grills C., McCrudden C.M., Gunasekharan V., Shi Z., Wong S.Y., Lappin T.R., Chan K.W., Fennell D.A., Khoo U.S., Johnston P.G. and El-Tanani M., Polyomavirus enhancer activator 3 protein promotes breast cancer metastatic progression through Snail-induced epithelial-mesenchymal transition, J Pathol. 2011, 224(1): 78-89.

Yuen H.F., McCrudden C.M., Chan K.K., Chan Y.P., Wong M.L.Y., Chan Y.K., Khoo U.S., Law S., Srivastava G., Lappin T.R., Chan K.W. and El-Tanani M., The role of pea3 group transcription factors in esophageal squamous cell carcinoma, Am J Pathol. 2011, 179 (2): 992-1003.

Researcher : Yuen KM

List of Research Outputs

Chan M.C.W., Chan W.Y., Yen H., Yu C.L., Yuen K.M., Tang L.L.S., Li C.L., Kang S.R., Hui F.F., Lai W.W.K., Sihoe A.D.L., Guan Y., Nicholls J.M. and Peiris J.S.M., ) Tropism and innate host response of the 2009 pandemic H1N1 influenza virus compared with related swine influenza viruses and reassortants in ex vivo and in vitro cultures of the human respiratory tract and conjunctiva, Options for the Control of Influenza VII, 2010.

Chan M.C.W., Chan W.Y., Yen H., Yu C.L., Yuen K.M., Tang L.L.S., Li C.L., Kang S.R., Hui F.F., Lai W.W.K., Sihoe A.D.L., Guan Y., Nicholls J.M. and Peiris J.S.M., Tropism and innate host response of the 2009 pandemic H2N2 influenza virus compared with related swine influenza viruses and reassortants in ex vivo and in vitro cultures of the human respiratory tract and conjunctiva, Influenza and other respiratory viruses. 2011, 5 (S1): 54-55.

Chan W.Y., Yuen K.M., Yu C.L., Tang L.L.S., Li C.L., Nicholls J.M. and Chan M.C.W., Replication of avian and seasonal influenza viruses in human bronchus and lung, Influenza and other respiratory viruses. 2011, 5: 425-426.

Yen H., Liang C., Wu C., Forrest H., Ferguson A., Choy K.T., Jones J., Wong D.D.Y., Cheung P.H.P., Hsu C., Li O.T.W., Yuen K.M., Chan W.Y., Poon L.L.M., Chan M.C.W., Nicholls J.M., Krauss S., Wong C.H., Guan Y., Webster R.G., Webby R. and Peiris J.S.M., Hemagglutinin-neuraminidase balance confers respiratory droplet transmissibility of the pandemic H1N1 influenza virus in ferrets, Keystone Symposia (Pathogenesis of Influenza: Virus-Host Interactions), May 23-28, 2011, Hong Kong SAR. 2011.

Yuen K.M., Chan W.Y., Mok K.P., Wong A.C.N., Kang S.R., Nicholls J.M. and Chan M.C.W., Differential onset of apoptosis in avian influenza H5N1 and seasonal H1N1 virus infected human bronchial and alveolar epithelial cell, an in vitro and ex vivo study, Options for the Control of Influenza VII. 2010.

Yuen K.M., Chan W.Y., Mok K.P., Wong C.N., Kang S.R., Nicholls J.M. and Chan M.C.W., Differential onset of apoptosis in avian influenza H5N1 and seasonal H1N1 virus infected human bronchial and alveolar epithelial cells: an in vitro and ex vivo study, Influenza and other respiratory viruses. 2011, 5 (S1): 437-438.

Researcher : Yuen KM

List of Research Outputs

Researcher : Yuen LYP

List of Research Outputs

Lee H.H.C., Mak C.M., Lam C.W., Yuen L.Y.P., Chan A.O.K., Shek C.C., Siu T.S., Lai C.K., Ching D.C.K., Siu C.W.K., Chen S.P.L., Law C.Y., Tai M.H.L., Tam S. and Chan A.Y.W., Analysis of inborn errors of metabolism: disease spectrum for expanded newborn screening in Hong Kong, Chinese Medical Journal (English Edition). 2011, 124(7): 983-9.

Siu C.W.K., Ma R.C., Lam C.W., Mak C.M., Yuen L.Y.P., Lo F.M., Chan K.W., Lam S.F., Ling S.C., Tong S.F., So W.Y., Chow C.C., Tang M.H., Tam W.H. and Chan A.Y.W., Molecular basis of von Hippel-Lindau syndrome in Chinese patients, Chinese Medical Journal (English Version). 2011, 124(2): 237-41.

Researcher : Zhang H

List of Research Outputs

Zhang H., Siu K.Y., Jiang L., Mak C.Y., Ngan H.Y.S., Wong G.W. and Cheung A.N.Y., Overexpressed PAK4 promotes proliferation, migration and invasion of choriocarcinoma., Carcinogenesis. 2011, 32: 765-771.

Researcher : Zhang L

List of Research Outputs

Khoo U.S., Zhang L., Cheung Y.N., Chan Y.K., Ip Y.C., Wong S.U. and Tsang W.H., Splice variant profiling of tamoxifen sensitive and resistance breast cancer, 27th HUGO-IABCR Congress 2010, Singapore. 2010.

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