DENTAL FACULTY - ORAL BIOSCIENCES



Researcher : Bandara HMHN

List of Research Outputs

Bandara H.M.H.N., Lam L.T., Jin L. and Samaranayake L.P., Microbial chemical signaling: a current perspective, Critical Reviews in Microbiology. 2012, 38: 217-249.
Bandara H.M.H.N., Samaranayake L.P., Tsang P.C.S. and Tsang W.K., Purpurin alters the architecture of Candida albicans biofilms. , 25th IADR Annual Scientific Meeting 2011. Journal of Dental Research. Singapore, 2011 . 2011.
Bandara H.M.H.N., Samaranayake L.P., Tsang P.C.S. and Tsang W.K., Purpurin alters the architecture of Candida albicans biofilms, Journal of Dental Research. 2011, 90 (Special Issue B): 176.
Samaranayake Y.H., Bandara H.M.H.N., Cheung B.P.K., Yau J.Y.Y., Yeung S.K.W. and Samaranayake L.P., Interactions of C. albicans and Bacterial species on Catheter Surfaces, IADR - SEAADE Annual Meeting 29-30 October 2011, Singapore. 2011.


Researcher : Chen W

List of Research Outputs

Yang W., Chen W., Wang H., Ho J.W.S., Huang J., Woo P.C.Y., Lau S.K.P., Yuen K.Y., Zhang Q., Zhou W., Bartlam M., Watt R.M. and Rao Z., Structural and functional insight into the mechanism of an alkaline exonuclease from Laribacter hongkongensis, Nucleic Acids Research. 2011, 39(22): 9803-19.


Researcher : Choi MY

Project Title:The stringent response and biofilm development in Staphylococcus aureus: the role of Rel-family proteins
Investigator(s):Choi MY, Watt RM
Department:Dental Faculty
Source(s) of Funding:Small Project Funding
Start Date:08/2010
Completion Date:01/2012


List of Research Outputs

Chan W.L., Choi M.Y., Chan C.C.Y., Chan D., Yu S.S., Cheah K.S.E. and Tanner J.A., Sedlin and prostaglandin E2 dehydrogenase – interactions and implications for spondyloepiphyseal dysplasia tarda, RE(ACT) Congress, Basel, Switzerland . 2012.
Choi M.Y., Wong L.Y., Wang Y., Chen W., Tanner J.A. and Watt R.M., Biochemical characterization of Gppa-ppx homologues from Mycobacterium tuberculosis, 25th IADS-SEA Division Scientific Meeting, Singapore. 2011.
Choi M.Y., Wong L.Y., Tanner J.A. and Watt R.M., Characterization and mutational analysis of an exopolyphosphatase from Mycobacterium smegmatis, 25th IADS-SEA Division Scientific Meeting, Singapore. 2011.


Researcher : Samaranayake YH

Project Title:84th General Session and Exhibition of the International Association for Dental Research (IADR) Synergistic Effect of Lysozyme and Amphotericin B on Candida Biofilms
Investigator(s):Samaranayake YH
Department:Dental Faculty
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2006


List of Research Outputs

Samaranayake Y.H., Cheung B.P.K., Yau J.Y.Y., Samaranayake L.P. and Yeung S.K.W., Characteristics of single and dual species Candida biofilms on catheter surfaces, Conjoint Scientific Meeting, Faculty of Dentistry, The University of Hong Kong - Sichuan University West China College of Stomatology 24-25 November 2011.
Samaranayake Y.H., Bandara H.M.H.N., Cheung B.P.K., Yau J.Y.Y., Yeung S.K.W. and Samaranayake L.P., Interactions of C. albicans and Bacterial species on Catheter Surfaces, IADR - SEAADE Annual Meeting 29-30 October 2011, Singapore. 2011.


Researcher : Seneviratne CJ

Project Title:Cross-talk of host oral epithelial cells with commensal and pathogenic bacteria
Investigator(s):Seneviratne CJ, Samaranayake LP, Jin L, Lau ASY, Lu L
Department:Dental Faculty
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:07/2010
Completion Date:07/2011


Project Title:Multiplex PCR array for detection and quantification of caries associated bacteria
Investigator(s):Seneviratne CJ, Lo ECM, Samaranayake LP, Gao X
Department:Dental Faculty
Source(s) of Funding:Seed Funding Programme for Applied Research
Start Date:11/2010


Project Title:Structure-Activity Relationship of Novel Antifungal Small molecule against Candida
Investigator(s):Seneviratne CJ, Kao RYT, Wang Y, Samaranayake LP
Department:Dental Faculty - Oral Biosciences
Source(s) of Funding:Small Project Funding
Start Date:12/2011


Project Title:Research Output Prize (Faculty of Dentistry)
Investigator(s):Seneviratne CJ
Department:Dental Faculty - Oral Biosciences
Source(s) of Funding:Research Output Prize (in Faculty)
Start Date:12/2011


Project Title:International Association for Dental Research General Session Structure-Activity Relationship of Novel Antifungal Small Molecule against Candida
Investigator(s):Seneviratne CJ
Department:Dental Faculty - Oral Biosciences
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2012
Completion Date:06/2012


List of Research Outputs

Chen Y., Wong R.W.K., Seneviratne C.J., Hagg E.U.O., McGrath C.P.J. and Samaranayake L.P., Comparison of the Antimicrobial Activity of Listerine® and Corsodyl® on Orthodontic Brackets In Vitro, American Journal of Orthodontics and Dentofacial Orthopedics. 2011, 140: Issue 4: 537-542.
Chen Y., Wong R.W.K., Seneviratne C.J., Hagg E.U.O., McGrath C.P.J. and Samaranayake L.P., Poster Presentation: The antimicrobial effect of Traditional Chinese Medicine mouthwash on patients undergoing orthodontic treatment with fixed appliance, The 10th Meeting of Consortium for Globalization of Chinese Medicine CGCM 2011, Shanghai, August 26 – 28, 2011.
Chu C.H., Mei L., Seneviratne C.J. and Lo E.C.M., Silver-diamine-fluoride on dentine infected with Streptococcus mutans and Lactobacillus acidophilus, Journal of Dental Research. 2011, 90 (Spec Iss B): 0027 (SEA Division).
Herath M.T.D.K.H., Wang Y., Seneviratne C.J., Darveau R...P..., Wang C...Y... and Jin L., 2011 International Association for Dental Research (IADR) - South East Asia Division /Unilever Hatton Divisional Award (Senior category), Singapore (Primary Supervisor for Ms. H.M.T.D.K. Herath, a PhD student), IADR - South East Asia Division. 2011.
Herath M.T.D.K.H., Wang Y., Seneviratne C.J., Darveau R.P., Wang C.Y. and Jin L., Novel pathogenic mechanisms of heterogeneous PG-LPS structures in periodontal disease, Journal of Dental Research. 2011, 90 (Spec Iss B): SD008 (SEA Division).
Herath M.T.D.K.H., Wang Y., Seneviratne C.J., Darveau R.P., Wang C. and Jin L., Novel pathogenic mechanisms of heterogeneous Pg-LPS structures in periodontal disease, Journal of Dental Research. 2012, 91 (Spec Iss B): 2643.
Li H., Seneviratne C.J., Lau A.S.Y. and Jin L., Crosstalk of human oral keratinocytes with commensal and pathogenic bacteria, Journal of Dental Research. 2011, 90 (Spec Iss B): SD007 (SEA Division).
Ng Y.L.N., Seneviratne C.J., Herath M.T.D.K.H., Jin L. and Samaranayake L.P., Mechanism of higher resistance in Enterococcus faecalis biofilm persister cells, Journal of Dental Research. 2011, 90 (Spec Iss B): JD007 (SEA Division).
Seneviratne C.J., Antifungal Susceptibility and Virulence Attributes of Bloodstream Isolates of Candida from Hong Kong and Finland. Seneviratne CJ, Wong SS, Yuen KY, Meurman JH, Pärnänen P, Vaara M, Samaranayake LP., Mycopathologia. 2011.
Seneviratne C.J., Best Oral Presentation Award for SSW Wong (PhDl student), HKU-SU 2011 conjoint scientific meeting, Sichuan, China, November, 2011 (co-supervisor), HKU-SU 2011 conjoint scientific meeting. 2011.
Seneviratne C.J., Biocide resistance of Candida and Escherichia coli biofilms may be associated with higher antioxidative capacities, J Hosp Infect. 2012 Jun;81(2):79-86. *corresponding author undergraduate research publication. 2012.
Seneviratne C.J., Guest Editor: Special Issue on Biofilms, International Journal of Dentistry, 2011.
Seneviratne C.J., IADR-SEA Division/ Joseph Lister Award in Oral Disease Prevention 2012 for CH Leung, 25th Annual Scientific Meeting, Southeast Asian Division of International Association for Dental Research, Singapore, 2011(supervisor), International Association for Dental Research. 2011.
Seneviratne C.J., IADR/ Unilever Hatton Award (Senior category) for TDK Herath (PhD student), 25th Annual Scientific Meeting, Southeast Asian Division of International Association for Dental Research, Singapore, 2011 (collaborator), International Association for Dental Research. 2011.
Seneviratne C.J., Yip W.Y., Gao X., Lo E.C.M., Jin L. and Samaranayake L.P., Multiplex Taqman-PRC-Array for identification and quantification of oral pathogenic bacteria, Journal of Dental Research. 2011, 90 (Spec Iss B): O135.
Seneviratne C.J., Outstanding Poster Presentation Award for TDK Herath (PhD student), 4th Hiroshima Conference on Education and Science in Dentistry, Hiroshima, Japan, September, 2011 (collaborator) , Faculty of Dentistry, Hiroshima University . 2011.
Seneviratne C.J., Research Output Prize for 2010, Faculty of Dentistry, The University of Hong Kong , The University of Hong Kong. 2011.
Seneviratne C.J., Travel Award, 10th CGCM Meeting for Yong Chen (PhD student), "The antimicrobial effect of Traditional Chinese Medicine mouthwash on patients undergoing orthodontic treatment with fixed appliance" Shanghai , China August, 2011 (co-author and mentor) , Consortium for Globalization of Chinese Medicine . 2011.
Seneviratne C.J., Wang Y., Jin L., Wong S.S.W., Herath M.T.D.K.H. and Samaranayake L.P., Unraveling the resistance of microbial biofilms: Has proteomics been helpful?, Proteomics. 2012, 12: 651-665.
Watamoto T., Samaranayake L.P., Egusa H., Yatani H. and Seneviratne C.J., Transcriptional regulation of drug-resistance genes in Candida albicans biofilms in response to antifungals (corresponding author), Journal of Medical Microbiology. 2011, 60: 1241-1247.


Researcher : Tsang WK

Project Title:Generation of focused libraries by combinatorial biocatalysis with anti-Candidal activity: synthesis and in vitro study
Investigator(s):Tsang WK
Department:Dental Faculty
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Mini Grants
Start Date:01/2009


Project Title:Phytate utilization in Candida albicans: possible link to pathogenesis?
Investigator(s):Tsang WK, Samaranayake LP
Department:Dental Faculty
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2010
Completion Date:06/2012


Project Title:From vital to lethal: functional analysis of apoptosis-inducing factor in the human fungal pathogen Candida albicans
Investigator(s):Tsang WK
Department:Dental Faculty - Oral Biosciences
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Mini Grants
Start Date:12/2011


Project Title:Investigation of the functional significance of phytase activity in Candida albicans: gene disruption, pH regulation, and virulence study
Investigator(s):Tsang WK, Samaranayake LP
Department:Dental Faculty - Oral Biosciences
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:03/2012


Project Title:18th Congress of the International Society for Human and Animal Mycology Effects of purpurin on proton-pumping ATPase and morphological transition in Candida albicans
Investigator(s):Tsang WK
Department:Dental Faculty - Oral Biosciences
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2012
Completion Date:06/2012


List of Research Outputs

Bandara H.M.H.N., Samaranayake L.P., Tsang P.C.S. and Tsang W.K., Purpurin alters the architecture of Candida albicans biofilms, Journal of Dental Research. 2011, 90 (Special Issue B): 176.
Tsang P.C.S. and Tsang W.K., Aspirin as an antifungal lock therapy agent, Journal of Dental Research. 2011, 90 (Special Issue B): 177.
Tsang W.K., Differential phytate utilization in Candida species, Mycopathologia. Springer, 2011, 172: 473-479.
Tsang W.K., Editorial Board, ISRN Biochemistry. 2012.
Tsang W.K. and Fong W.P., Effects of purpurin on proton-pumping ATPase and morphological transition in Candida albicans, The 18th Congress of the International Society for Human and Animal Mycology. 2012.
Tsang W.K., Journal Editor, Open Journal of Medical Microbiology. Scientific Research Publishing, 2011.
Tsang W.K., Lead Faculty in Microbiology, WebmedCentral. United Kingdom, Webmed Limited, 2011.


Researcher : Watt RM

Project Title:A Molecular toolbox for genetic, proteomic and metabolic engineering in the ethanol-producing bacterium Zymomonas mobilis
Investigator(s):Watt RM, Huang J
Department:Chemistry
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2009
Completion Date:06/2012


Project Title:Genes get 'recT' : new and improved methods for bacterial DNA engineering
Investigator(s):Watt RM, Huang J, Tanner JA
Department:Dental Faculty
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2010


Project Title:A molecular typing system for Treponema denticola: an enigmatic oral pathogen
Investigator(s):Watt RM, Leung WK
Department:Dental Faculty
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2010
Completion Date:03/2012


Project Title:New approaches for the analysis of microbial biofilms associated with periodontal disease
Investigator(s):Watt RM, Leung WK
Department:Dental Faculty
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2011


Project Title:Treponema denticola and periodontal disease: novel analytical approaches to probe host-pathogen relationships
Investigator(s):Watt RM, Leung WK, Tanner JA
Department:Dental Faculty
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2012


Project Title:Stress response in the oral pathogen Fusobacterium nucleatum: the interplay between polyphosphate metabolism and the stringent response
Investigator(s):Watt RM, Seneviratne CJ, Choi MY
Department:Dental Faculty - Oral Biosciences
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2012


List of Research Outputs

Bandara H.M.H.N., Watt R.M., Jin L. and Samaranayake L.P., Bacterial quorum sensors cross communicate with Candida during biofilm development, Journal of Dental Research. 2011, 90 (Spec Iss B): SD016 (SEA Division).
Choi M.Y., Wong L.Y., Wang Y., Chen W., Tanner J.A. and Watt R.M., Biochemical characterization of Gppa-ppx homologues from Mycobacterium tuberculosis, 25th IADS-SEA Division Scientific Meeting, Singapore. 2011.
Choi M.Y., Wong L.Y., Tanner J.A. and Watt R.M., Characterization and mutational analysis of an exopolyphosphatase from Mycobacterium smegmatis, 25th IADS-SEA Division Scientific Meeting, Singapore. 2011.
Curreem S.O.T., Watt R.M., Lau S.K.P. and Woo P.C.Y., Two-dimensional gel electrophoresis in bacterial proteomics, Protein & Cell. 2012, 3: 346-363.
So L.Y. and Watt R.M., Development of versatile expression vectors for biological and biotechnological applications in the ethanologenic bacterium Zymomonas mobilis, Society for General Microbiology Spring Conference. 2012, GM/37.
Yang W., Chen W., Wang H., Ho J.W.S., Huang J., Woo P.C.Y., Lau S.K.P., Yuen K.Y., Zhang Q., Zhou W., Bartlam M., Watt R.M. and Rao Z., Structural and functional insight into the mechanism of an alkaline exonuclease from Laribacter hongkongensis, Nucleic Acids Research. 2011, 39(22): 9803-19.


Researcher : Wong LY

Project Title:An investigation on p21-activated protein kinase 1 inhibitor, IPA-3, in hepatocellular carcinoma
Investigator(s):Wong LLY, Ching YP
Department:Anatomy
Source(s) of Funding:Small Project Funding
Start Date:06/2012


List of Research Outputs

Choi M.Y., Wong L.Y., Wang Y., Chen W., Tanner J.A. and Watt R.M., Biochemical characterization of Gppa-ppx homologues from Mycobacterium tuberculosis, 25th IADS-SEA Division Scientific Meeting, Singapore. 2011.
Choi M.Y., Wong L.Y., Tanner J.A. and Watt R.M., Characterization and mutational analysis of an exopolyphosphatase from Mycobacterium smegmatis, 25th IADS-SEA Division Scientific Meeting, Singapore. 2011.


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