Dept of Biochemistry

DEPT OF BIOCHEMISTRY

Researcher : Ao KL

List of Research Outputs

Ao K.L., Shum K.T. and Tanner J.A., Dissecting the mechanism of binding between polyphosphate and polyphosphate kinase 2, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Researcher : Au YK

Project Title:	Developing a culture system for notochord and nucleus pulposus cells
Investigator(s):	Au YK, Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	03/2012

Project Title:	World Forum for Spine Research 2012: The Intervertebral Disc—from Degeneration to Pain Generation of mouse notochord cell lines for the study of notochord function during intervertebral disc development
Investigator(s):	Au YK
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2012

List of Research Outputs

Au Y.K., Chan D. and Cheah K.S.E., Generation of mouse notochord cell lines for the study of notochord function during intervertebral disc development, In: Jeffrey C. Wang, M.D., Global Spine Journal World Forum for Spine Research 2012 The Intervertebral Disc-from Degeneration to Pain. AOSPINE, 2012, 2.

Au Y.K., Traval/Training Award, University of Hong Kong/China Medical Board Grants 2011/2012. 2012.

Cheah K.S.E., Szeto Y.Y., Au Y.K., Wynn S., Mak A.C.Y., Chan Y.S., Lovell-Badge R., Chan W.Y. and Fritzsch B., Defects in cochlear structure and function in the Sox9Y440X campomelic dysplasia mouse model , Wellcome Trust scientific conferences : 8th Molecular Biology of Hearing and Deafness Conference. 2011.

Guo S., Au Y.K., Wynn S., Chan D., Aszodi A., Fassler R. and Cheah K.S.E., An essential role for β1 integrin mediated cell-matrix interactions in the development and maintenance of the nucleus pulposus, World Forum for Spine Research 2012: The Intervertebral Disc- from Degeneration to Pain, Helsinki, Finland. Jun 18-21, 2012.. 2012.

Lam T.K., Au Y.K., Wynn S., Chan D., Cheah K.S.E., Leung Y.L. and Cheung K.M.C., Fate and Properties of Notochordal Descendent Cells in the Intervertebral Disc: Implication to Disc Degeneration, World Forum for Spine Research 2012: The Intervertebral Disc- from Degeneration to Pain, Helsinki, Finland. 2012.

Lam T.K., Au Y.K., Wynn S., Chan D., Chan D., Cheah K.S.E., Leung Y.L. and Cheung K.M.C., Fate and properties of notochordal descendent cells in the intervertebral disc: Implicationto disc degeneration, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.. 2011.

Leung Y.L., Gao B., Leung K.K.H., Melhado I.G., Wynn S.L., Au Y.K., Dung W.F., Lau J.Y.B., Mak A.C.Y., Chan D. and Cheah K.S.E., Sox9 governs differentiation stage-specific gene expression in growth plate chondrocytes via direct concomitant transactivation and repression., PLoS Genetics. 2011, 7(11): e1002356.

Wang M., Tsang K.Y., Au Y.K., Guo S., Chan D. and Cheah K.S.E., The role of Prkci in the development of notochord, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Yeung C.W., Au Y.K., Gao Y., Chan D., Cheah K.S.E. and Chan B.P., Developing three dimensional culture system for Notochordal cells. , World Forum for Spine Research - The Intervertebral disc - from degeneration to pain. 18-21 Jun, 2012. Helsinki, Finland.. 2012, P116.

Researcher : Bao S

List of Research Outputs

Li M., Gui H., Kwan S.H., Bao S. and Sham P.C., A Comprehensive Framework For Prioritizing Variants In Exome Sequencing Studies Of Mendelian Diseases, Nucleic Acids Research. 2012.

Researcher : Bevan SJ

List of Research Outputs

Hau C.H., Liu Z., Chan L.S., Chiu H.C., Ng T.W., Yung S.P., Tsang K.M., Wong C.W., Chan K.H., Tsing N.K., Chan Y.M., Lau Y.K., Cheung W.S., Han G., Zang W., Ching W.K., Tong P.L., Wong E.L.M., Chan W.K., Lo C.S.C., Lam K.F., Djurisic A., Bevan S.J. and Cheung S.L., Faculty KE Award 2012, Faculty of Science, The University of Hong Kong. 2012.

Researcher : Boyde TRC

List of Research Outputs

Waye M.M.Y., Baum L., Boyde T.R.C., Chan K.K.K., Cherny S.S., Choy F., Garcia-Barcelo M.M., Gong Z., Kagawa H., Kotaka M., Lee C.Y., Lee S.M.Y., Li H.Y., Meng H., Ng R.K., Ng T.B., Pollard J., Qi R., Shen D.W., Tam S.S.W., Tsang F.S.Y., Wasylyk B., Xue H. and Siu C.O., Journal of Biochemistry and Molecular Biology in the Post Genomic Era. 2011.

Researcher : Cham WC

List of Research Outputs

Lam Y.L., Cham W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Involvement of proheparanase and peri-synaptic heparan sulfate proteoglycan in synaptic plasticity to regulate AMPA-Type glutamate receptor trafficking, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Lam Y.L., Cham W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Modulation of synaptic plasticity by the partnership of proheparanase with peri-synaptic heparan sulfate proteoglycan and AMPA-type glutamate receptor, Abstracts of 7th Int’l Symp. on Healthy Aging: 73. 2012.

Lam Y.L., Cham W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Proheparanase-mediated AMPA-type glutamate receptor regulation in synaptic plasticity, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Lam Y.L., Cham W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Regulation of AMPA-type glutamate receptor trafficking by proheparanase in synaptic plasticity, Society Neuroscience Abstract (USA), 870.09/D41. 2011.

Lam Y.L., Cham W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Regulatory role of proheparanase with peri-synaptic heparan sulfate proteoglycan and AMPA-type glutamate receptor in synaptic plasticity, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 73. 2012.

Ma C.W., Cham W.C., Lai C.H., Chan Y.S. and Shum D.K.Y., The regulatory role of proheparanase in synaptic plasticity at the hippocampus, 8th IBRO World Congress of Neuroscience, Florence, Italy. July 14-18, B199. 2011.

Ma C.W., Cham W.C., Lai C.H., Shum D.K.Y. and Chan Y.S., The role of proheparanase in synaptic plasticity at the hippocampus, 9th Biennial Conference of the Chinese Neuroscience Society and The 5th Member Congress, Zhengzhou, China. Jul 29 - Aug 1, P-110. 2011.

Researcher : Cham WC

List of Research Outputs

Researcher : Chan CCY

List of Research Outputs

Chan W.L., Choi M.Y., Chan C.C.Y., Chan D., Yu S.S.B., Cheah K.S.E. and Tanner J.A., Sedlin and prostaglandin E2 dehydrogenase – interactions and implications for spondyloepiphyseal dysplasia tarda,, International Congress on Research of Rare and Orphan Diseases, Basel, Switzerland, 29 February-2 March 2012.. 2012.

Chan W.L., Choi M.Y., Chan C.C.Y., Chan D., Yu S.S., Cheah K.S.E. and Tanner J.A., Sedlin and prostaglandin E2 dehydrogenase – interactions and implications for spondyloepiphyseal dysplasia tarda, RE(ACT) Congress, Basel, Switzerland . 2012.

Researcher : Chan CH

List of Research Outputs

Chan K.H., Chan C.H., Yeung S.C., Man R.Y.K., Ip M.S.M. and Mak J.C.W., Inhibitory effect of Chinese green tea on cigarette smoke-induced up-regulation of airway neutrophil elastase and matrix metalloproteinase-12 via antioxidant activity, Free Radical Research. 2012, Epub ahead of print.

Lau K.W., Chan C.H., Law A.C.K., Ip M.S.M. and Mak J.C.W., The role of MAPK and Nrf2 pathways in ketanserin-elicited attenuation of cigarette smoke-induced IL-8 production in human bronchial epithelial cells, Toxicol Sci. 2012, 125(2): 569-577.

Wong Y.K., Han S.J., Chan C.H., Shum D.K.Y., Chan G.C.F. and Chan B.P., Characterization of human mesenchymal stem cells selected by collagen barrier., Tissue Engineering and Regenerative Medicine International Society Asia-Pacific Chapter Meeting (TERMIS-AP) 3-5 Aug 2011. Waterfront Conference Centre, Singapore.. 2011, 182.

Wu L.K., Chan C.H., Ip M.S.M. and Shum D.K.Y., Heparanase Activity Facilitates Syndecan-1 Shedding in Airway Inflammation, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Researcher : Chan CP

List of Research Outputs

Chan C.P., Kok K.H. and Jin D., Activation of protein secretory pathway by fusion oncoprotein FUS-CREB3L2 in low-grade fibromyxoid sarcoma, 13th SCBA International Symposium of the Society of Chinese Bioscientists in America (SCBA), Guangzhou, China. 2011.

Tang V.H.M., Siu Y.T., Chan C.P., Ching Y.P., Kok K.H. and Jin D., LKB1 tumor suppressor is a negative regulator of Tax-mediated transcriptional activation of human T-cell leukemia virus type 1 long terminal repeats, 13th SCBA International Symposium. Society of Chinese Bioscientists in America (SCBA). Guangzhou, China. 2011.

Tang V.H.M., Siu Y.T., Chan C.P., Kok K.H. and Jin D., STK11 inhibits transcriptional activation of HTLV-I LTR by Tax transactivator, The 70th Annual Meeting of the Japanese Cancer Association (JCA). 2011.

Researcher : Chan CP

List of Research Outputs

Researcher : Chan CWW

List of Research Outputs

Chan C.W.W., Sze K.L., Samartzis D., Leung V. and Chan D., Structure and biology of the intervertebral disc in health and disease, Orthopaedic Clinics of North America. 2011.

Feng C., Hu J., Chan C.W.W., Ng H.U.C.K. .H.U.I. and Chan D., Role of IHH signaling in the progression of digit joint formation, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Researcher : Chan CY

List of Research Outputs

Chong T.Y.I., Chan C.Y., Lee C.Y.L., Shiu S.Y.W., Li J.Y.H. and Yao K.M., Establishing a Cell-based Platform to identify Molecules for Directing the Differentiation of Human Embryonic Stem Cells into Insulin-secreting β-like cells, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Researcher : Chan D

Project Title:	Genome-wide identification and functional studies of genetic risk factors for low back pain and intervertebral disc degeneration
Investigator(s):	Chan D
Department:	Biochemistry
Source(s) of Funding:	AOSpine International - General Award
Start Date:	08/2007

Project Title:	Role of Indian hedgehog signaling in phalangeal joint formation and Brachydactylies
Investigator(s):	Chan D, Cheah KSE, Cheung MCH
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2009

Project Title:	Research Output Prize (Li Ka Shing Faculty of Medicine)
Investigator(s):	Chan D
Department:	Biochemistry
Source(s) of Funding:	Research Output Prize (in Faculty)
Start Date:	12/2010

Project Title:	Interplay between ER stress and hypoxic stress in the regulation of chondrocyte differentiation
Investigator(s):	Chan D, Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2012

List of Research Outputs

Au Y.K., Chan D. and Cheah K.S.E., Generation of mouse notochord cell lines for the study of notochord function during intervertebral disc development, In: Jeffrey C. Wang, M.D., Global Spine Journal World Forum for Spine Research 2012 The Intervertebral Disc-from Degeneration to Pain. AOSPINE, 2012, 2.

Chan C.W.W., Sze K.L., Samartzis D., Leung V. and Chan D., Structure and biology of the intervertebral disc in health and disease, Orthopaedic Clinics of North America. 2011.

Chan D., Concepts, Pain Genetics Symposium: From basic Science to Clinical Applications,, From basic Science to Clinical Applications, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China, Jun 9 2012. 2012.

Chan D., Genes and Diseases: Basic Concepts, Pain Genetics Symposium: From basic Science to Clinical Applications, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 9 June 2012.. 2012.

Chan D., Mechanisms of hereditary factors, World Forum for Spine Research 2012: The Intervertebral Disc- from Degeneration to Pain, Helsinki, Finland, 18-21, 2012.

Chan D., The role of genetics in pain, World Forum for Spine Research 2012: The Intervertebral Disc- from Degeneration to Pain, Helsinki, Finland, 18-21, 2012.

Chan W.C.W., Tsang K.Y., Ng V.C.W., Boot-Handford R., Cheah K.S.E. and Chan D., Activating ER-stress in differentiating osteocytes impairs maturation causing hyperostosis in mice , Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012.. 2012.

Chan W.C.W., Zhang L., Chan W.Y., Cheah K.S.E. and Chan D., Cells in the endplate cartilage contribute to the inner annulus fibrosus in the intervertebral disc, World Forum for Spine Research 2012: The Intervertebral Disc- from Degeneration to Pain, Helsinki, Finland, 18-21, 2012.

Chan W.C.W., Sze K.L., Samartzis D., Leung Y.L. and Chan D., Structure and biology of the intervertebral disk in health and disease, Orthop Clin North Am. 2011, 4: 447-64.

Chan W.L., Choi M.Y., Chan C.C.Y., Chan D., Yu S.S.B., Cheah K.S.E. and Tanner J.A., Sedlin and prostaglandin E2 dehydrogenase – interactions and implications for spondyloepiphyseal dysplasia tarda,, International Congress on Research of Rare and Orphan Diseases, Basel, Switzerland, 29 February-2 March 2012.. 2012.

Chan W.L., Choi M.Y., Chan C.C.Y., Chan D., Yu S.S., Cheah K.S.E. and Tanner J.A., Sedlin and prostaglandin E2 dehydrogenase – interactions and implications for spondyloepiphyseal dysplasia tarda, RE(ACT) Congress, Basel, Switzerland . 2012.

Cheah K.S.E., Wang C., Tan Z., Niu B., Tsang K.Y., Melhado I.G., Zhang M.Q. and Chan D., Transcriptional control of chondrocyte differentiation and their adaptation to ER stress in vivo , Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012.

Cheah K.S.E., Wang C., Tan Z., Niu B., Tsang K.Y., Melhado I.G., Zhong M. and Chan D., Transcriptional control of chondrocyte differentiation and their adaptation to ER stress in vivo, Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012. 2012.

Eskola P...J..., Lemmela S., Kjaer P...K..., Solovieva S., Mannikko M., Tommerup N., Lind-Thomsen A., Husgafvel-Pursiainen K., Cheung K.M.C., Chan D., Samartzis D. and Karppiene J., Genetic association studies in lumbar disc degeneration: a systematic review,, World Forum for Spine Research 2012: The Intervertebral Disc- from Degeneration to Pain, Helsinki, Finland. Jun 18-21, 2012.. 2012.

Fan Y., Cheung K.M.C., Chan D., Cheung W.Y., Cheah K.S.E., Sham P.C., Luk K.D.K. and Song Y., Genome-Wide Association Study of Adolescent Idiopathic Scoliosis in Southern Chinese, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Fan Y., Song Y., Chan D., Takahashi Y., Ikegawa S., Matsumoto M., Kou I., Cheah K.S.E., Sham P.C., Cheung K.M.C. and Luk K.D.K., SNP rs11190870 near LBX1 is associated with adolescent idiopathic scoliosis in southern Chinese., J Hum Genet . 2011, 57(4): 244-6.

Feng C., Hu J., Chan C.W.W., Ng H.U.C.K. .H.U.I. and Chan D., Role of IHH signaling in the progression of digit joint formation, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Feng C., Stricker S., Hu J., Mundlos S., Hui N.H. and Chan D., Role of IHH signaling in the progression of joint formation in digit development, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Gan H., Zhu G., Xue W., Chan D., Cheah K.S.E. and Huang J., Kinesin-1 is necessary for cytokinesis in chondrocytes, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.. 2012.

Gan H., Zhu G., Xue W., Chan D., Cheah K.S.E. and Huang J., Kinesin-1 is necessary for cytokinesis in chondrocytes, Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012.. 2012.

Gan H., Zhu G., Xue W., Chan D., Cheah K.S.E. and Huang J., Roles of kinesin-1 mediated intracellular transport in skeletal development, Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012.. 2012.

Guo S., Au Y.K., Wynn S., Chan D., Aszodi A., Fassler R. and Cheah K.S.E., An essential role for β1 integrin mediated cell-matrix interactions in the development and maintenance of the nucleus pulposus, World Forum for Spine Research 2012: The Intervertebral Disc- from Degeneration to Pain, Helsinki, Finland. Jun 18-21, 2012.. 2012.

Kao P.Y.P., Chan D., Samartzis D., Sham P.C. and Song Y., Genetics of lumbar disk degeneration: technology, study designs, and risk factors, Orthop Clin North Am. 2011, 42(4): 479-86.

Kelempisioti A., Eskola P.J., Okuloff A., Karjalainen U., Takatalo J., Daavittila I., Niinimaki J., Sequeiros R.B., Tervonen O., Solovieva S., Kao P.Y.P., Song Y., Cheung K.M.C., Chan D., Ala-Kokko L., Jarvelin M.R., Karppinen J. and Mannikko M., Genetic susceptibility of intervertebral disc degeneration among young Finnish adults, BMC Medical Genetics. 2011, 12: 153.

Lam T.K., Au Y.K., Wynn S., Chan D., Cheah K.S.E., Leung Y.L. and Cheung K.M.C., Fate and Properties of Notochordal Descendent Cells in the Intervertebral Disc: Implication to Disc Degeneration, World Forum for Spine Research 2012: The Intervertebral Disc- from Degeneration to Pain, Helsinki, Finland. 2012.

Lam T.K., Au Y.K., Wynn S., Chan D., Chan D., Cheah K.S.E., Leung Y.L. and Cheung K.M.C., Fate and properties of notochordal descendent cells in the intervertebral disc: Implicationto disc degeneration, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.. 2011.

Lee K.S., Lam T.K., Cheah K.S.E., Cheung K.M.C. and Chan D., In vivo study of Asporin, a genetic risk factor for intervertebral disc degeneration, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Leung Y.L., Gao B., Leung K.K.H., Melhado I.G., Wynn S.L., Au Y.K., Dung W.F., Lau J.Y.B., Mak A.C.Y., Chan D. and Cheah K.S.E., Sox9 governs differentiation stage-specific gene expression in growth plate chondrocytes via direct concomitant transactivation and repression., PLoS Genetics. 2011, 7(11): e1002356.

Leung Y.L., Aladin K.D.M., Lv F., Tam V., Sun Y., Lu W.W., Wu E.X., Luk K.D.K., Chan D. and Cheung K.M.C., Mesenchymal stem cells mediate disc regeneration by suppression of fibrosis in nucleus pulposus, World Forum for Spine Research 2012: The Intervertebral Disc- from Degeneration to Pain, Helsinki, Finland, 18-21, 2012.

Leung Y.L., Aladin K.D.M., Lv F., Tam V., Sun Y., Tang B., Ngan A.H.W., Luk K.D.K., Chan D. and Cheung K.M.C., Mesenchymal stromal cells rescue disc degeneration and function via suppression of fibrotic events, Days of Molecular Medicine, AAAS. 2011.

Leung Y.L., Tam V., Chan D., Chan B.P. and Cheung K.M.C., Tissue engineering for intervertebral disk degeneration, Orthopedic Clinics of North America. 2011, 42(4): 575-584.

Li Y.Y., Cheng H.W., Chan P.M., Wong M.Y., Teng W.K., Chow S.T., Cheung K.M.C., Chan D. and Chan B.P., Collagen-mesenchymal stem cell microspheres for the repair of articular cartilage defects in a rabbit model., Cold Srping Harbor Asia Conference - Bone and cartilage: From development to human diseases. Jun 11-15, 2012, Suzhou, China.. 2012, 86.

Lim F.L., Cheung K.M.C., Chan D., Tuan R. and Leung Y.L., Cadherin 2 as human notochordal cell marker and its expression pattern in disc degeneration, World Forum for Spine Research 2012: The Intervertebral Disc- from Degeneration to Pain, Helsinki, Finland. 2012.

Ng V.C.W., Chan W.C.W., Gauci S., Fosang A. and Chan D., Role of type II collagen turnover in disc development and degeneration , World Forum for Spine Research 2012, Marina Congress Centre, Helsinki, Finland, 18-21 June, 2012.

Samartzis D., Karppinen J.I., Chan D., Luk K.D.K. and Cheung K.M.C., Intervertebral disc degeneration on MRI is associated with low back pain: a population-based study,, Triennial World Congress, Prague, Czech Republic. Sep 6-9, 2011.

Samartzis D., Karppiene J..., Chan D., Luk K.D.K. and Cheung K.M.C., The Intervertebral Disc- from Degeneration to Pain, Helsinki, Finland. Jun 18-21, 2012, The association of intervertebral disc degeneration on MRI and low back pain: a population-based study, World Forum for Spine Research 2012.

Samartzis D., Karppinen J., Chan D., Luk K.D.K. and Cheung K.M.C., The association of lumbar intervertebral disc degeneration on magnetic resonance imaging with body mass index in overweight and obese adults: a population-based study, Arthritis & Rheumatism. 2012, 64(5): 1488-1496.

Shen Y., Ng V.C.W., Shen W., Norito S., Cheung S.K.C., Agata K., Chan B.P., Lam Y.W. and Chan D., Extracellular matrix and stem cell niche in the regenerating planarian, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Shen Y., Ng V.C.W., Shen W., Norito S., Cheung S.K.C., Agata K., Chan B.P., Lam Y.W. and Chan D., Extracellular matrix and the stem cell niche in the regenerating planarian, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Tam V., Rogers I., Chan D. and Cheung K.M.C., Best Short Talk Presentation Award: Can stem cells home to the injured intervertebral disc via intravenous infusion? A murine model, World Forum for Spine Research . 2012.

Tam V., Rogers I., Chan D. and Cheung K.M.C., Can stem cells home to the injured intervertebral disc via intravenous infusion? A murine model, World Forum for Spine Research, 2012, Finland. 2012.

Tam W.K., Cheung K.M.C., Leung Y.L. and Chan D., Role of hypoxia inducible factor-alpha (HIF-a) genes in chondrogenesis, 2012.

Tang S.M., Cheng G., So M.T., Yip B.H.K., Miao X., Wong E.H.M., Ngan E.S.W., Lui V.C.H., Song Y., Chan D., Cheung K.M.C., Yuan Z.W., Lei L., Chung H.Y., Liu X., Wong K.K.Y., Marshall C.R., Scherer S., Cherny S.S., Sham P.C., Tam P.K.H. and Garcia-Barcelo M.M., Genome-wide copy number analysis uncovers a new HSCR gene: NRG3, PLoS Genetics. 2012, 8(5): e1002687.

Tong W.Y.T., Shen W., Yeung C.W.F., Zhao Y., Cheng S.H., Chu P.K., Chan D., Chan G.C.F., Cheung K.M.C., Yeung K.W.K. and Lam Y.W., Functional replication of the tendon tissue microenvironment by a bioimprinted substrate and the support of tenocytic differentiation of mesenchymal stem cells, Biomaterials. 2012.

Tsang S.W., Yang Y.Z., Chan D. and Cheah K.S.E., Loss of b-Catenin in hypertrophic chondrocytes results in abnormal bone formation, Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012.. 2012.

Tsang S.W., Yang Y.Z., Chan D. and Cheah K.S.E., Loss of β-catenin in hypertrophic chondrocytes results in abnormal bone formation., Cold Spring harbor Conferences Asia – Bone & Cartilage: From Development to Human Diseases, 11-15 June 2012, Suzhou, China.. 2012.

Wang C., Tan Z., Tsang K.Y., Leung K.K.H., Ron D., Chan D. and Cheah K.S.E., The Role of PERK Pathway in adaptation of Hypertrophci Chondrocytes to ER Stress. , Joint Meeting of The 45th Annual Meeting of the Japanese Society of Developmental Biologists & The 64th Annual Meeting of the Japan Society for Cell Biology , Kobe, Japan, May 28-31, 2012 . 2012.

Wang C., Tan Z., Tsang K.Y., Leung K.K.H., Chan D. and Cheah K.S.E., (The Best Poster Award) The role of PERK pathway in adaptation of hypertrophic condrocytes to ER stress, Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012.. 2012.

Wang C., Tan Z., Tsang K.Y., Leung K.K.H., Chan D. and Cheah K.S.E., The role of PERK pathway in adaptation of hypertrophic chondrocytes to ER stress, Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012.. 2012.

Wang M., Tsang K.Y., Au Y.K., Guo S., Chan D. and Cheah K.S.E., The role of Prkci in the development of notochord, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Wang X., Cheung M.C.H., Tam P.P.L., Briscoe J. and Chan D., Molecular consequences of Indian Hedgehog mutations causing brachydactylies in chick neural tube, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Wang Y., Lu L., Wu M.H., Chan D., Cheah K.S.E. and Cheung M.C.H., Generation of induced pluripotent stem (iPS) cells from bone- formating cells, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Wang Y., Lu L., Wu M.H., Sham M.H., Chan D., Cheah K.S.E. and Cheung K.M.C., Induction of osteo-chondroprogenitors formation during transcription factor-mediated reprogramming processes, 10th Annual Meeting of International Society for Stem Cell Research, Yokohama, Japan. Jun 13-16 2012.. 2012.

Yan C.H., Qiu Y., Chiu P.K.Y., Cheung K.M.C., Chan D., Kao Y.P.P. and Ng F.Y., Interleukin-1 Beta (il-1b) And Osteoprotegerin (opg) Gene Polymorphisms Are Associated With Knee Osteoarthritis In Chinese, Orthopaedic Basic Science Award, 31st Hong Kong Orthopaedic Association Annual Congress 2011. 2011.

Yan C.H., Qiu Y., Chiu P.K.Y., Cheung K.M.C., Chan D. and Ng F.Y., Interleukin-1 Beta (il-1b) And Osteoprotegrin (opg) Gene Polymorphisms Are Associated With Knee Osteoarthritis In Chinese , The 31st Hong Kong Orthopaedic Association Annual Congress. 2011.

Yan C.H., Qiu Y., Chiu P.K.Y., Cheung K.M.C., Chan D. and Ng F.Y., Interleukin-1 beta and osteoprotegrin gene polymorphisums are associated with knee osteoarthritis in Chinese , 31st Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 19-20, 2011.

Yan C.H., Qiu Y., Chiu P.K.Y., Cheung K.M.C., Chan D., Kao Y.P.P. and Ng F.Y., Osteoprotegerin (opg) And Interleukin-1 Beta (il-1b) Gene Polymorphisms Are Associated With Knee Osteoarthritis In Chinese, 6th International Congress Of Chinese Orthopaedic Association. 2011.

Yan C.H., Qiu Y., Chiu P.K.Y., Cheung K.M.C., Chan D., Kao Y.P.P. and Ng F.Y., The Association of Osteoprotegerin Gene Polymorphism with Knee Osteoarthritis in Chinese Population, 34th Singaporean Orthopaedic Association Annual Scientific Meeting. 2011.

Yao Q., Ng V.C.W., Tan Z., Chan W.C.W., Tsang K.Y., Cheah K.S.E. and Chan D., Interplay between ER stree and hypoxia pathways in chondrocytes, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Yeung C.W., Au Y.K., Gao Y., Chan D., Cheah K.S.E. and Chan B.P., Developing three dimensional culture system for Notochordal cells. , World Forum for Spine Research - The Intervertebral disc - from degeneration to pain. 18-21 Jun, 2012. Helsinki, Finland.. 2012, P116.

Yip K.H.R., Wu M.H., Cheah K.S.E., Chan D. and Cheung M.C.H., Identification and Characterization of Long-range SOX9 Enhancers in Limb Development, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.. 2012.

Researcher : Chan D.

Project Title:	Genome-wide identification and functional studies of genetic risk factors for low back pain and intervertebral disc degeneration
Investigator(s):	Chan D
Department:	Biochemistry
Source(s) of Funding:	AOSpine International - General Award
Start Date:	08/2007

Project Title:	Role of Indian hedgehog signaling in phalangeal joint formation and Brachydactylies
Investigator(s):	Chan D, Cheah KSE, Cheung MCH
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2009

Project Title:	Research Output Prize (Li Ka Shing Faculty of Medicine)
Investigator(s):	Chan D
Department:	Biochemistry
Source(s) of Funding:	Research Output Prize (in Faculty)
Start Date:	12/2010

Project Title:	Interplay between ER stress and hypoxic stress in the regulation of chondrocyte differentiation
Investigator(s):	Chan D, Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2012

List of Research Outputs

Researcher : Chan JKM

List of Research Outputs

Chan J.K.M., Wong H.L.X., Jin G., Liu B., Cao R., Cao Y., Lehti K., Tryggvason K. and Zhou Z., MT1-MMP Inactivates ADAM9 to Regulate FGFR2 Signaling and Calvarial Osteogenesis, Developmental Cell. 2012, 22: 1176-1190.

Researcher : Chan KMJ

List of Research Outputs

Chan K.M.J., Wong H.L.X., Jin G., Cao R., Cao Y., Lehti K. and Zhou Z., MT1-MMP Inactivates ADAM9 to Regulate FGFR2 Signaling in Calvarial Osteogenesis. , Developmental Cell . Cell Press, 2012, 22 (6): 1176-1190.

Researcher : Chan SCL

List of Research Outputs

Leung C., Chan S.C.L., Tsang S.L., Wu W. and Sham M.H., Cyb26b1 mediates differential regulation of RA signaling in neural progenitor populations along the anterior-posterior axis of the adult spinal cord, Days of Molecular Medicine 2011, Re-engineering Regenerative Medicine, Hong Kong, 10-12 November 2011.

Leung C., Chan S.C.L., Tsang S.L., Wu W. and Sham M.H., Cyp26b mediates differential neurogenicity in axial-specific populations of adult spinal cord progenitor cells., Stem Cells and Development. 2012, Epub ahead of print.

Researcher : Chan SLC

List of Research Outputs

Tanner J.A., Shum K.T. and Chan S.L.C., High-affinity nucleic acid aptamers against sclerostin protein, PCT Patent. 2011, WO2011/147193.

Researcher : Chan W.L.

Project Title:	RE-ACT International Congress on Research of Rare and Orphan Diseases Sedlin and prostaglandin E2 dehydrogenase – interactions and implications for spondyloepiphyseal dysplasia tarda
Investigator(s):	Chan WL
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	02/2012
Completion Date:	03/2012

List of Research Outputs

Researcher : Chan WCW

Project Title:	Role of Endogenous Stem/Progenitor cells in the maintenance and regeneration of Intervertebral Discs
Investigator(s):	Chan WCW, Chan D
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	06/2012

Project Title:	World Forum for Spine Research 2012: The Intervertebral Disc—from Degeneration to Pain Cells in the endplate cartilage contribute to the inner annulus fibrosus in the intervertebral disc
Investigator(s):	Chan WCW
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2012

List of Research Outputs

Chan W.C.W., Tsang K.Y., Ng V.C.W., Boot-Handford R., Cheah K.S.E. and Chan D., Activating ER-stress in differentiating osteocytes impairs maturation causing hyperostosis in mice , Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012.. 2012.

Chan W.C.W., Zhang L., Chan W.Y., Cheah K.S.E. and Chan D., Cells in the endplate cartilage contribute to the inner annulus fibrosus in the intervertebral disc, World Forum for Spine Research 2012: The Intervertebral Disc- from Degeneration to Pain, Helsinki, Finland, 18-21, 2012.

Chan W.C.W., Sze K.L., Samartzis D., Leung Y.L. and Chan D., Structure and biology of the intervertebral disk in health and disease, Orthop Clin North Am. 2011, 4: 447-64.

Ng V.C.W., Chan W.C.W., Gauci S., Fosang A. and Chan D., Role of type II collagen turnover in disc development and degeneration , World Forum for Spine Research 2012, Marina Congress Centre, Helsinki, Finland, 18-21 June, 2012.

Yao Q., Ng V.C.W., Tan Z., Chan W.C.W., Tsang K.Y., Cheah K.S.E. and Chan D., Interplay between ER stree and hypoxia pathways in chondrocytes, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Researcher : Chan WL

Project Title:	RE-ACT International Congress on Research of Rare and Orphan Diseases Sedlin and prostaglandin E2 dehydrogenase – interactions and implications for spondyloepiphyseal dysplasia tarda
Investigator(s):	Chan WL
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	02/2012
Completion Date:	03/2012

List of Research Outputs

Chan W.L., Choi M.Y., Chan C.C.Y., Chan D., Yu S.S.B., Cheah K.S.E. and Tanner J.A., Sedlin and prostaglandin E2 dehydrogenase – interactions and implications for spondyloepiphyseal dysplasia tarda,, International Congress on Research of Rare and Orphan Diseases, Basel, Switzerland, 29 February-2 March 2012.. 2012.

Chan W.L., Choi M.Y., Chan C.C.Y., Chan D., Yu S.S., Cheah K.S.E. and Tanner J.A., Sedlin and prostaglandin E2 dehydrogenase – interactions and implications for spondyloepiphyseal dysplasia tarda, RE(ACT) Congress, Basel, Switzerland . 2012.

Zong M., Wu X.G., Chan W.L., Choi M.Y., Chan H.C., Tanner J.A. and Yu S., The adaptor function of TRAPPC2 in mammalian TRAPPs explains TRAPPC2-associated SEDT and TRAPPC9-associated congenital intellectual disability, PLoS ONE. 2011, 6 (8): e23350.

Researcher : Chan WY

List of Research Outputs

Chan W.C.W., Zhang L., Chan W.Y., Cheah K.S.E. and Chan D., Cells in the endplate cartilage contribute to the inner annulus fibrosus in the intervertebral disc, World Forum for Spine Research 2012: The Intervertebral Disc- from Degeneration to Pain, Helsinki, Finland, 18-21, 2012.

Researcher : Cheah K.S.E.

Project Title:	The role of Type II procollagens encoded by alternatively spliced forms of aI(II) procollagen mRNA in cartilage differnetiation and growth
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Arthritis and Rheumatism Council (ARC) - General Award
Start Date:	12/1993

Project Title:	Defining the role of the transcription factor Sox9 in skeletal development by tissue-specific gene inactivation
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	UK/Hong Kong Joint Research Scheme
Start Date:	02/1998

Project Title:	4th Pan-Pacific Connective Tissues Societies Symposium Abnormal Regulation of Cartilage and Bone Growth in Transgenic Mice Expressing a Collagen X SMCD Mution
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/1999

Project Title:	Human Genome Meeting 2001 Genomic Analysis of the Mutant Locus in the Novel Transgenic Mouse Mutant, Yellow Submarine (ysb)
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2001

Project Title:	67th Cold Spring Harbor Symposium on Quantitative Biology - The Cardiovascular System An Essential Role for Type IIA Procollagen in Heart Development
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2002

Project Title:	1st Annual Meeting of the American Society for Matrix Biology Type IIA Procollagen is Essential for Proper Heart Development
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2002

Project Title:	The Gordon Research Conference on Cartilage Biology and Pathology Chondrocytes Survive ER Stress Caused by Unfolded Proteins and Differentiation is Re-programmed
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2005

Project Title:	11th Human Genome Meeting Procollagen IIA Facilitates BMP Signaling in Heart Development
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2006

Project Title:	Cold Spring Harbor Laboratory Meeting on Mouse Molecular Genetics Insight into the Molecular Pathogenesis of Campomelic Dysplasia Received By A Conditional SOX9 Mutant Mouse Model
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2006

Project Title:	Development and Reproduction
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	09/2008
Completion Date:	08/2011

Project Title:	Role of Sox2 in the stemness of dermal precursors
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2010

Project Title:	Genetic analyses of sensory fate determination in inner ear development
Investigator(s):	Cheah KSE, Lok S
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2010

Project Title:	The role of Snail factor in skeletal development: Physiology and Pathology
Investigator(s):	Cheah KSE, Cheung MCH, Chan D
Department:	Biochemistry
Source(s) of Funding:	CSIC / RGC Joint Research Scheme
Start Date:	07/2011

Project Title:	World Forum for Spine Research: The Intervertebral Disc - from Degeneration to Pain Multidisciplinary disc research
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2012

List of Research Outputs

Researcher : Cheah KSE

Project Title:	The role of Type II procollagens encoded by alternatively spliced forms of aI(II) procollagen mRNA in cartilage differnetiation and growth
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Arthritis and Rheumatism Council (ARC) - General Award
Start Date:	12/1993

Project Title:	Defining the role of the transcription factor Sox9 in skeletal development by tissue-specific gene inactivation
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	UK/Hong Kong Joint Research Scheme
Start Date:	02/1998

Project Title:	4th Pan-Pacific Connective Tissues Societies Symposium Abnormal Regulation of Cartilage and Bone Growth in Transgenic Mice Expressing a Collagen X SMCD Mution
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/1999

Project Title:	Human Genome Meeting 2001 Genomic Analysis of the Mutant Locus in the Novel Transgenic Mouse Mutant, Yellow Submarine (ysb)
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2001

Project Title:	67th Cold Spring Harbor Symposium on Quantitative Biology - The Cardiovascular System An Essential Role for Type IIA Procollagen in Heart Development
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2002

Project Title:	1st Annual Meeting of the American Society for Matrix Biology Type IIA Procollagen is Essential for Proper Heart Development
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2002

Project Title:	The Gordon Research Conference on Cartilage Biology and Pathology Chondrocytes Survive ER Stress Caused by Unfolded Proteins and Differentiation is Re-programmed
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2005

Project Title:	11th Human Genome Meeting Procollagen IIA Facilitates BMP Signaling in Heart Development
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2006

Project Title:	Cold Spring Harbor Laboratory Meeting on Mouse Molecular Genetics Insight into the Molecular Pathogenesis of Campomelic Dysplasia Received By A Conditional SOX9 Mutant Mouse Model
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2006

Project Title:	Development and Reproduction
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	09/2008
Completion Date:	08/2011

Project Title:	Role of Sox2 in the stemness of dermal precursors
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2010

Project Title:	Genetic analyses of sensory fate determination in inner ear development
Investigator(s):	Cheah KSE, Lok S
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2010

Project Title:	The role of Snail factor in skeletal development: Physiology and Pathology
Investigator(s):	Cheah KSE, Cheung MCH, Chan D
Department:	Biochemistry
Source(s) of Funding:	CSIC / RGC Joint Research Scheme
Start Date:	07/2011

Project Title:	World Forum for Spine Research: The Intervertebral Disc - from Degeneration to Pain Multidisciplinary disc research
Investigator(s):	Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2012

List of Research Outputs

Au Y.K., Chan D. and Cheah K.S.E., Generation of mouse notochord cell lines for the study of notochord function during intervertebral disc development, In: Jeffrey C. Wang, M.D., Global Spine Journal World Forum for Spine Research 2012 The Intervertebral Disc-from Degeneration to Pain. AOSPINE, 2012, 2.

Chan W.C.W., Tsang K.Y., Ng V.C.W., Boot-Handford R., Cheah K.S.E. and Chan D., Activating ER-stress in differentiating osteocytes impairs maturation causing hyperostosis in mice , Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012.. 2012.

Chan W.C.W., Zhang L., Chan W.Y., Cheah K.S.E. and Chan D., Cells in the endplate cartilage contribute to the inner annulus fibrosus in the intervertebral disc, World Forum for Spine Research 2012: The Intervertebral Disc- from Degeneration to Pain, Helsinki, Finland, 18-21, 2012.

Chan W.L., Choi M.Y., Chan C.C.Y., Chan D., Yu S.S.B., Cheah K.S.E. and Tanner J.A., Sedlin and prostaglandin E2 dehydrogenase – interactions and implications for spondyloepiphyseal dysplasia tarda,, International Congress on Research of Rare and Orphan Diseases, Basel, Switzerland, 29 February-2 March 2012.. 2012.

Chan W.L., Choi M.Y., Chan C.C.Y., Chan D., Yu S.S., Cheah K.S.E. and Tanner J.A., Sedlin and prostaglandin E2 dehydrogenase – interactions and implications for spondyloepiphyseal dysplasia tarda, RE(ACT) Congress, Basel, Switzerland . 2012.

Cheah K.S.E., 3rd International Sox Meeting: From Structure to Function, Grainau, Germany, From Structure to Function, Grainau, Germany,11-15 Sept. 11-15, 2011.. 2011.

Cheah K.S.E., Szeto Y.Y., Au Y.K., Wynn S., Mak A.C.Y., Chan Y.S., Lovell-Badge R., Chan W.Y. and Fritzsch B., Defects in cochlear structure and function in the Sox9Y440X campomelic dysplasia mouse model , Wellcome Trust scientific conferences : 8th Molecular Biology of Hearing and Deafness Conference. 2011.

Cheah K.S.E., Mechanistic insights into chondrodysplasia caused by ER-stress revealed by genetic and transcriptome analyses, Integrative Omics-Conference on Disease Mechanisms – from emerging, Freiburg im Breisgau, Germany, 9-11 October 2011. . 2011.

Cheah K.S.E., Mouse as a model for functional genetic studies, Pain Genetics Symposium: From basic Science to Clinical Applications, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 9 June 2012.. 2012.

Cheah K.S.E., Multidisciplinary disc research, World Forum for Spine Research 2012: The Intervertebral Disc- from Degeneration to Pain, Helsinki, Finland, 18-21, 2012.

Cheah K.S.E., Multidisciplinary disc research, World Forum for Spine Research 2012: The Intervertebral Disc- from Degeneration to Pain, Helsinki, Finland, 18-21, 2012. 2012.

Cheah K.S.E., Sox proteins and inner ear development, The 3rd International Sox Meeting: From Structure to Function, Grainau, Germany, 11-15 September 2011. . 2011.

Cheah K.S.E., Wang C., Tan Z., Niu B., Tsang K.Y., Melhado I.G., Zhang M.Q. and Chan D., Transcriptional control of chondrocyte differentiation and their adaptation to ER stress in vivo , Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012.

Cheah K.S.E., Wang C., Tan Z., Niu B., Tsang K.Y., Melhado I.G., Zhong M. and Chan D., Transcriptional control of chondrocyte differentiation and their adaptation to ER stress in vivo, Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012. 2012.

Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Best Poster Award: Sox10 is essential for neural crest invasion in cochleo-vastibular ganglion. , 2012 Inter-University Postgraduate Symposium on Life Science, HKUST, Hong Kong, 9 June 2012.. 2012.

Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Sox10 is Essential for Neural Crest Invasion in Cochlea-Vestibular Ganglion, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Chu K.H., Zhang M., Wong E.Y.M., Chan Y.S., Cheah K.S.E. and Sham M.H., Sox10 is essential for neural crest invasion in cochleo-vastibular ganglion, 2012 Inter-University Postgraduate Symposium on Life Science, HKUST, Hong Kong, 9 June 2012.

Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Sox10 is essential for neural crest invasion in cochleo-vastibular ganglion, The 3rd International Symposium on Development of the Enteric Nervous System Cells, Signals and Genes, Hong Kong, 25-28 March, 2012.

Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Sox10 mutation affects gliogenesis of the cochleo-vestibular ganglion in mouse inner ear development, Third International Sox Meeting: From Structure to Function, Grainau, Munich, Germany, 11-14 September 2011.

Chu T.L., Tsang K.Y. and Cheah K.S.E., The role of MT1-MMP in regulating lineage progression of chondrocytes , 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012. . 2012.

Fan Y., Cheung K.M.C., Chan D., Cheung W.Y., Cheah K.S.E., Sham P.C., Luk K.D.K. and Song Y., Genome-Wide Association Study of Adolescent Idiopathic Scoliosis in Southern Chinese, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Fan Y., Song Y., Chan D., Takahashi Y., Ikegawa S., Matsumoto M., Kou I., Cheah K.S.E., Sham P.C., Cheung K.M.C. and Luk K.D.K., SNP rs11190870 near LBX1 is associated with adolescent idiopathic scoliosis in southern Chinese., J Hum Genet . 2011, 57(4): 244-6.

Gan H., Zhu G., Xue W., Chan D., Cheah K.S.E. and Huang J., Kinesin-1 is necessary for cytokinesis in chondrocytes, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.. 2012.

Gan H., Zhu G., Xue W., Chan D., Cheah K.S.E. and Huang J., Kinesin-1 is necessary for cytokinesis in chondrocytes, Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012.. 2012.

Gan H., Zhu G., Xue W., Chan D., Cheah K.S.E. and Huang J., Roles of kinesin-1 mediated intracellular transport in skeletal development, Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012.. 2012.

Grskovic I., Kutsch A., Frie C., Groma G., Stermann J., Schlötzer-Schrehardt U., Niehoff A., Moss S.E., Rosenbaum S S., Pöschl E., Chmielewski M., Rappl G., Abken H., Bateman J.F., Cheah K.S.E., Paulsson M. and Brachvogel B., Depletion of annexin A5, annexin A6 and collagen X causes no gross changes in matrix vesicle mediated mineralization, but lack of collagen X affects hematopoiesis and the Th1/Th2 response., Journal of Bone and Mineral Research. 2012, doi: 10.1002/jbmr.1682.: [Epub ahead of print].

Guo S., Au Y.K., Wynn S., Chan D., Aszodi A., Fassler R. and Cheah K.S.E., An essential role for β1 integrin mediated cell-matrix interactions in the development and maintenance of the nucleus pulposus, World Forum for Spine Research 2012: The Intervertebral Disc- from Degeneration to Pain, Helsinki, Finland. Jun 18-21, 2012.. 2012.

Ho B.S.-.Y., Cheng C.C.W., Leung K.K.H., Koopman P. and Cheah K.S.E., The role of Sox2 in mouse hair morphogenesis, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Lam T.K., Au Y.K., Wynn S., Chan D., Cheah K.S.E., Leung Y.L. and Cheung K.M.C., Fate and Properties of Notochordal Descendent Cells in the Intervertebral Disc: Implication to Disc Degeneration, World Forum for Spine Research 2012: The Intervertebral Disc- from Degeneration to Pain, Helsinki, Finland. 2012.

Lam T.K., Au Y.K., Wynn S., Chan D., Chan D., Cheah K.S.E., Leung Y.L. and Cheung K.M.C., Fate and properties of notochordal descendent cells in the intervertebral disc: Implicationto disc degeneration, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.. 2011.

Lee K.S., Lam T.K., Cheah K.S.E., Cheung K.M.C. and Chan D., In vivo study of Asporin, a genetic risk factor for intervertebral disc degeneration, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Leung Y.L., Gao B., Leung K.K.H., Melhado I.G., Wynn S.L., Au Y.K., Dung W.F., Lau J.Y.B., Mak A.C.Y., Chan D. and Cheah K.S.E., Sox9 governs differentiation stage-specific gene expression in growth plate chondrocytes via direct concomitant transactivation and repression., PLoS Genetics. 2011, 7(11): e1002356.

Matheu A., Collado M., Wise C., Manterola I., Cekaite L., Tye A.J., Canamero M., Bujanda L., Schedl A., Cheah K.S.E., Skotheim R.I., Lothe R.A., Lopez de Munain A., Briscoe J., Serrano M. and Lovell-Badge R.H., Oncogenicity of the Developmental Transcription Factor Sox9. , Cancer Research . 2012, 72: 1301-1315.

Ng T.T., Sham M.H., Cheah K.S.E. and Ng R.K., Regeneration of nucleus pulposus cells for degenerative disc disorder, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Tsang S.W., Yang Y.Z., Chan D. and Cheah K.S.E., Loss of b-Catenin in hypertrophic chondrocytes results in abnormal bone formation, Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012.. 2012.

Tsang S.W., Yang Y.Z., Chan D. and Cheah K.S.E., Loss of β-catenin in hypertrophic chondrocytes results in abnormal bone formation., Cold Spring harbor Conferences Asia – Bone & Cartilage: From Development to Human Diseases, 11-15 June 2012, Suzhou, China.. 2012.

Wang C., Tan Z., Tsang K.Y., Leung K.K.H., Ron D., Chan D. and Cheah K.S.E., The Role of PERK Pathway in adaptation of Hypertrophci Chondrocytes to ER Stress. , Joint Meeting of The 45th Annual Meeting of the Japanese Society of Developmental Biologists & The 64th Annual Meeting of the Japan Society for Cell Biology , Kobe, Japan, May 28-31, 2012 . 2012.

Wang C., Tan Z., Tsang K.Y., Leung K.K.H., Chan D. and Cheah K.S.E., (The Best Poster Award) The role of PERK pathway in adaptation of hypertrophic condrocytes to ER stress, Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012.. 2012.

Wang C., Tan Z., Tsang K.Y., Leung K.K.H., Chan D. and Cheah K.S.E., The role of PERK pathway in adaptation of hypertrophic chondrocytes to ER stress, Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012.. 2012.

Wang M., Tsang K.Y., Au Y.K., Guo S., Chan D. and Cheah K.S.E., The role of Prkci in the development of notochord, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Wang Y., Lu L., Wu M.H., Chan D., Cheah K.S.E. and Cheung M.C.H., Generation of induced pluripotent stem (iPS) cells from bone- formating cells, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Wang Y., Lu L., Wu M.H., Sham M.H., Chan D., Cheah K.S.E. and Cheung K.M.C., Induction of osteo-chondroprogenitors formation during transcription factor-mediated reprogramming processes, 10th Annual Meeting of International Society for Stem Cell Research, Yokohama, Japan. Jun 13-16 2012.. 2012.

Yao Q., Ng V.C.W., Tan Z., Chan W.C.W., Tsang K.Y., Cheah K.S.E. and Chan D., Interplay between ER stree and hypoxia pathways in chondrocytes, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Yeung C.W., Au Y.K., Gao Y., Chan D., Cheah K.S.E. and Chan B.P., Developing three dimensional culture system for Notochordal cells. , World Forum for Spine Research - The Intervertebral disc - from degeneration to pain. 18-21 Jun, 2012. Helsinki, Finland.. 2012, P116.

Yip K.H.R., Wu M.H., Cheah K.S.E., Chan D. and Cheung M.C.H., Identification and Characterization of Long-range SOX9 Enhancers in Limb Development, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.. 2012.

Yuan Q., Su H., Guo J., Tsang K.Y., Cheah K.S.E., Chiu K., Yang J., Wong W.M., So K.F., Huang J., Wu W. and Lin Z.X., Decreased c-jun expression correlates with impaired spinal motoneuron regeneration in aged mice following sciatic nerve crush, Experimental Gerontology. 2012, 47: 329-336.

Yuan Q.J., Su H., Guo J.S., Tsang K.Y., Cheah K.S.E., Chiu K.I.N., Yang J., Wong W.M., So K.F., Huang J., Wu W. and Lin Z.X., Decreased c-Jun expression correlates with impaired spinal motoneuron regeneration in aged mice following sciatic nerve crush., Exp Gerontol. Elsevier Inc., 2012, 47: 329-36.

Researcher : Chen L

List of Research Outputs

Chen L., Kao P.Y.P., Fan Y., Ho D.T.Y., Yik P.Y., Ha C.T., Chu L.W. and Song Y., Association between CLU Polymorphisms and clinical phenotypes in Alzheimer’s Disease, Alzheimer's Association International Conference (AAIC) . 2011.

Chen L., Kao P.Y.P., Fan Y., Ho T.Y., Yik P.Y., Ha C.T.J., Chu L.W. and Song Y., Polymorphisms of CR1, CLU and PICALM confer susceptibility of Alzheimer's disease in a southern Chinese population , Neurobiol Aging. 2012, 33(1):210.e: 1-7.

Chen L., Kao P.Y.P., Fan Y., Chu L.W. and Song Y., The genetic polymorphisms in sex steroid metabolic pathway and risk for sporadic Alzheimer's disease, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Zhou L., Chan K.H., Chu L.W., Kwan S.C., Song Y., Chen L., Ho W.L., Cheng O.Y., Ho W.M. and Lam K.S.L., Plasma amyloid-β oligomers level is a biomarker for Alzheimer’s disease diagnosis, Biochemical and Biophysical Research Communications. 2012, 423(4): 697-702.

Researcher : Cheng CCW

List of Research Outputs

Ho B.S.-.Y., Cheng C.C.W., Leung K.K.H., Koopman P. and Cheah K.S.E., The role of Sox2 in mouse hair morphogenesis, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Researcher : Cheng LYL

Project Title:	A concordance study of the importance of autosomal short tandem repeat (STR) and Y-chromosome STR in the Chinese community
Investigator(s):	Cheng LYL, Tan-Un KC
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002

Researcher : Cheung MCH

Project Title:	In vivo Functional Analysis of Posttranslational Modifications of Sox9 in Neural Crest Development
Investigator(s):	Cheung MCH, Zhou G
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2010

Project Title:	In vivo identification and characterization of cis-regulatory elements and upstream effectors to control Sox9 expression at the onset of neural crest specification
Investigator(s):	Cheung MCH
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2012

List of Research Outputs

Hui M.N., Wu M.H., Chan K.K. and Cheung M.C.H., Investigating the role of Sox9 in human neural stem cells, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Kam K.M., Cheung M.C.H., Tam P.K.H. and Lui V.C.H., Hoxb5 trans-activates Sox9 and regulates trunk neural crest cell development, The 3rd International Symposium on Development of the Enteric Nervous System Cells, Signals and Genes, Hong Kong, 25-28 March 2012.

Wang X., Cheung M.C.H., Tam P.P.L., Briscoe J. and Chan D., Molecular consequences of Indian Hedgehog mutations causing brachydactylies in chick neural tube, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Wang Y., Lu L., Wu M.H., Chan D., Cheah K.S.E. and Cheung M.C.H., Generation of induced pluripotent stem (iPS) cells from bone- formating cells, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Yip K.H.R., Wu M.H., Cheah K.S.E., Chan D. and Cheung M.C.H., Identification and Characterization of Long-range SOX9 Enhancers in Limb Development, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.. 2012.

Researcher : Cheung YW

List of Research Outputs

Cheung Y.W. and Tanner J.A., Aptamers against P. falciparum histidine rich protein 2 as a new approach to malaria diagnosis. , Croucher Advanced Study Institute (ASI) ‘Structure-based screening and design of ligands for protein targets’, Chinese University of Hong Kong. 2011.

Cheung Y.W. and Tanner J.A., Detection of Plasmodium falciparum lactate dehydrogenase by Aptamer-nanoparticle conjugates, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Tanner J.A. and Cheung Y.W., DNA aptamers against plasmodium lactate dehydrogenase and histidine-rich protein II for malaria diagnosis and therapy, US Provisional Patent. 2012, 61/596774.

Tanner J.A., Kinghorn A.B. and Cheung Y.W., Nucleic Acid Aptamers for Sensing Applications – Aptamers for Diagnosing Malaria, EnGENEious, Oxford University, UK . 2012.

Researcher : Choi MY

Project Title:	The stringent response and biofilm development in Staphylococcus aureus: the role of Rel-family proteins
Investigator(s):	Choi MY, Watt RM
Department:	Dental Faculty
Source(s) of Funding:	Small Project Funding
Start Date:	08/2010
Completion Date:	01/2012

List of Research Outputs

Chan W.L., Choi M.Y., Chan C.C.Y., Chan D., Yu S.S.B., Cheah K.S.E. and Tanner J.A., Sedlin and prostaglandin E2 dehydrogenase – interactions and implications for spondyloepiphyseal dysplasia tarda,, International Congress on Research of Rare and Orphan Diseases, Basel, Switzerland, 29 February-2 March 2012.. 2012.

Zong M., Wu X.G., Chan W.L., Choi M.Y., Chan H.C., Tanner J.A. and Yu S., The adaptor function of TRAPPC2 in mammalian TRAPPs explains TRAPPC2-associated SEDT and TRAPPC9-associated congenital intellectual disability, PLoS ONE. 2011, 6 (8): e23350.

Researcher : Choi MY

List of Research Outputs

Researcher : Chong TYI

List of Research Outputs

Chong T.Y.I., Chan C.Y., Lee C.Y.L., Shiu S.Y.W., Li J.Y.H. and Yao K.M., Establishing a Cell-based Platform to identify Molecules for Directing the Differentiation of Human Embryonic Stem Cells into Insulin-secreting β-like cells, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Researcher : Chow MZY

List of Research Outputs

Krishnan V., Chow M.Z.Y., Wang Z., Zhang L., Liu X. and Zhou Z., Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice, Proc Natl Aca Sci USA. 2011, 108: 12325-30.

Researcher : Chu KH

List of Research Outputs

Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Best Poster Award: Sox10 is essential for neural crest invasion in cochleo-vastibular ganglion. , 2012 Inter-University Postgraduate Symposium on Life Science, HKUST, Hong Kong, 9 June 2012.. 2012.

Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Sox10 is Essential for Neural Crest Invasion in Cochlea-Vestibular Ganglion, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Chu K.H., Sox10 is essential for neural crest invasion in cochlea-vastibular ganglion, 2012 Inter-University Postgraduate Symposium on Life Science, HKUST, Hong Kong, 9 June 2012.. 2012.

Chu K.H., Zhang M., Wong E.Y.M., Chan Y.S., Cheah K.S.E. and Sham M.H., Sox10 is essential for neural crest invasion in cochleo-vastibular ganglion, 2012 Inter-University Postgraduate Symposium on Life Science, HKUST, Hong Kong, 9 June 2012.

Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Sox10 is essential for neural crest invasion in cochleo-vastibular ganglion, The 3rd International Symposium on Development of the Enteric Nervous System Cells, Signals and Genes, Hong Kong, 25-28 March, 2012.

Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Sox10 mutation affects gliogenesis of the cochleo-vestibular ganglion in mouse inner ear development, Third International Sox Meeting: From Structure to Function, Grainau, Munich, Germany, 11-14 September 2011.

Liu Y., Chu K.H., Hui C.C. and Sham M.H., Best Poster Award: The roles of Irx3 and Irx5 genes in mammalian inner ear development., 2012 Inter-University Postgraduate Symposium on Life Science, HKUST, Hong Kong, 9 June 2012. . 2012.

Liu Y., Chu K.H., Hui C.C. and Sham M.H., The Roles of Irx3 and Irx5 Genes in Mammalian Inner Ear Development, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Liu Y., Chu K.H., Hui C.C. and Sham M.H., The roles of Irx3 and Irx5 genes inmammalian inner ear development, 2012 Inter-University Postgraduate Symposium on Life Science, HKUST, Hong Kong, 9 June 2012. . 2012.

Zhang M., Leung C., Sit H.M., Chu K.H., Lui V.C.H., Tam P.K.H. and Sham M.H., Sox10 ^NGFP mutation affects migration of enteric neural cress cells in mouse embryonic gut, The 3rd International Symposium on Development of the Enteric Nervous System Cells, Signals and Genes, Hong Kong, 25-28 March, 2012.

Researcher : Chu KH

List of Research Outputs

Chu K.H., Sox10 is essential for neural crest invasion in cochlea-vastibular ganglion, 2012 Inter-University Postgraduate Symposium on Life Science, HKUST, Hong Kong, 9 June 2012.. 2012.

Researcher : Chu TL

List of Research Outputs

Chu T.L., Tsang K.Y. and Cheah K.S.E., The role of MT1-MMP in regulating lineage progression of chondrocytes , 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012. . 2012.

Researcher : Chun CS

List of Research Outputs

Chun C.S. and Jin D., REV7-mediated polyubiquitination and degradation of human DNA translesion synthesis polymerase REV1., Society of Chinese Bioscientists in America, 13th International Symposium, Guangzhou, China. 2011.

Researcher : Dung WF

List of Research Outputs

Leung Y.L., Gao B., Leung K.K.H., Melhado I.G., Wynn S.L., Au Y.K., Dung W.F., Lau J.Y.B., Mak A.C.Y., Chan D. and Cheah K.S.E., Sox9 governs differentiation stage-specific gene expression in growth plate chondrocytes via direct concomitant transactivation and repression., PLoS Genetics. 2011, 7(11): e1002356.

Researcher : Fan Y

List of Research Outputs

Chen L., Kao P.Y.P., Fan Y., Ho D.T.Y., Yik P.Y., Ha C.T., Chu L.W. and Song Y., Association between CLU Polymorphisms and clinical phenotypes in Alzheimer’s Disease, Alzheimer's Association International Conference (AAIC) . 2011.

Chen L., Kao P.Y.P., Fan Y., Ho T.Y., Yik P.Y., Ha C.T.J., Chu L.W. and Song Y., Polymorphisms of CR1, CLU and PICALM confer susceptibility of Alzheimer's disease in a southern Chinese population , Neurobiol Aging. 2012, 33(1):210.e: 1-7.

Chen L., Kao P.Y.P., Fan Y., Chu L.W. and Song Y., The genetic polymorphisms in sex steroid metabolic pathway and risk for sporadic Alzheimer's disease, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Fan Y., Cheung K.M.C., Chan D., Cheung W.Y., Cheah K.S.E., Sham P.C., Luk K.D.K. and Song Y., Genome-Wide Association Study of Adolescent Idiopathic Scoliosis in Southern Chinese, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Fan Y. and Song Y., IPGWAS: An integrated pipeline for rational quality control and association analysis of genome-wide genetic studies, Biochem Biophys Res Commun. 2012, 422(3): 363-368.

Fan Y., Song Y., Chan D., Takahashi Y., Ikegawa S., Matsumoto M., Kou I., Cheah K.S.E., Sham P.C., Cheung K.M.C. and Luk K.D.K., SNP rs11190870 near LBX1 is associated with adolescent idiopathic scoliosis in southern Chinese., J Hum Genet . 2011, 57(4): 244-6.

Researcher : Fassler R

List of Research Outputs

Guo S., Au Y.K., Wynn S., Chan D., Aszodi A., Fassler R. and Cheah K.S.E., An essential role for β1 integrin mediated cell-matrix interactions in the development and maintenance of the nucleus pulposus, World Forum for Spine Research 2012: The Intervertebral Disc- from Degeneration to Pain, Helsinki, Finland. Jun 18-21, 2012.. 2012.

Researcher : Feng C

List of Research Outputs

Feng C., Hu J., Chan C.W.W., Ng H.U.C.K. .H.U.I. and Chan D., Role of IHH signaling in the progression of digit joint formation, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Feng C., Stricker S., Hu J., Mundlos S., Hui N.H. and Chan D., Role of IHH signaling in the progression of joint formation in digit development, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Researcher : Fu C

Project Title:	Investigation of the roles of kinesins and microtubule associated proteins in spindle length control at metaphase
Investigator(s):	Fu C
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	08/2011
Completion Date:	07/2012

Researcher : Gan H

List of Research Outputs

Gan H., Zhu G., Xue W., Chan D., Cheah K.S.E. and Huang J., Kinesin-1 is necessary for cytokinesis in chondrocytes, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.. 2012.

Gan H., Zhu G., Xue W., Chan D., Cheah K.S.E. and Huang J., Kinesin-1 is necessary for cytokinesis in chondrocytes, Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012.. 2012.

Gan H., Zhu G., Xue W., Chan D., Cheah K.S.E. and Huang J., Roles of kinesin-1 mediated intracellular transport in skeletal development, Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012.. 2012.

Researcher : Gao Y

List of Research Outputs

Yeung C.W., Au Y.K., Gao Y., Chan D., Cheah K.S.E. and Chan B.P., Developing three dimensional culture system for Notochordal cells. , World Forum for Spine Research - The Intervertebral disc - from degeneration to pain. 18-21 Jun, 2012. Helsinki, Finland.. 2012, P116.

Researcher : Guan X

Project Title:	49th Annual Meeting of the American Society of Human Genetics The Association of Chromosome 8p Deletion and Tumor Metastasis in Human Hepatocellular Carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/1999

Project Title:	51st Annual Meeting of the American Society of Human Genetics Loss of Tyrosine Aminotransferase may Contribute to the Development of Hepatocellular Carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/2001

Project Title:	Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	03/2009

Project Title:	Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	03/2009

Project Title:	Characterization of metastatic role of CHD1L in hepatocellular carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Small Project Funding
Start Date:	10/2009

Project Title:	Characterization of tumor suppressing function of CHL1 at a frequent deleted region 3p26.3 in esophageal squamous cell carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Small Project Funding
Start Date:	10/2010

Project Title:	Mass spectrometry-based metabolomics for the characterization of cellular metabolic pathways associated with the development of hepatocellular carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	04/2011

Project Title:	Characterization of tumor suppressive function and mechanism of CHL1 at a frequent deleted region 3p26.3 in esophageal squamous cell carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2011

Project Title:	The Liver Cancer Genome Project: translating genetic discoveries to clinical benefits
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	12/2011

Project Title:	Characterization of the role of Epstein-Barr virus encoded microRNA BART19-3p in enhancing tumor-initiating properties in nasopharyngeal carcinoma
Investigator(s):	Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

List of Research Outputs

Wang J., Chen L., Li Y. and Guan X., Overexpression of cathepsin Z contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma. , PLoS One. 2011, 6(9): e24967.

Researcher : Guo S

Project Title:	Investigating the role of cell-matrix interactions mediated by ß1 integrin in notochord cell polarity and cell migration
Investigator(s):	Guo S, Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	04/2011

Project Title:	World Forum for Spine Research 2012: The Intervertebral Disc from Degeneration to Pain An essential role for β1 integrin mediated cell-matrix interactions in the development and maintenance of the nucleus pulposus
Investigator(s):	Guo S
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2012

List of Research Outputs

Guo S., Au Y.K., Wynn S., Chan D., Aszodi A., Fassler R. and Cheah K.S.E., An essential role for β1 integrin mediated cell-matrix interactions in the development and maintenance of the nucleus pulposus, World Forum for Spine Research 2012: The Intervertebral Disc- from Degeneration to Pain, Helsinki, Finland. Jun 18-21, 2012.. 2012.

Wang M., Tsang K.Y., Au Y.K., Guo S., Chan D. and Cheah K.S.E., The role of Prkci in the development of notochord, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Researcher : Ho BS-Y

List of Research Outputs

Ho B.S.-.Y., Cheng C.C.W., Leung K.K.H., Koopman P. and Cheah K.S.E., The role of Sox2 in mouse hair morphogenesis, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Researcher : Ho TH

List of Research Outputs

Ng M.H., Ho T.H., Kok K.H., Siu K.L., Li J. and Jin D., MIP-T3 is a negative regulator of innate type I interferon response., J Immunol. 2011, 184: 6473-6482.

Ng M.H., Ho T.H., Siu K.L., Kok K.H. and Jin D., ROLES OF MITOCHONDRIAL TRAFFICKING PROTEINS IN TYPE-I INTERFERON PRODUCTION, 13th International Symposium of the Society of Chinese Bioscientists in America. 2011.

Researcher : Hor HH

List of Research Outputs

Hor H.H., Wang X., Hui C.C. and Sham M.H., Best Poster Award: Suppressor of fused (Su(fu)) plays domain specific function in orchestrating the maintenance and differentiation of hindbrain neural progenitor pools., 2012 Inter-University Postgraduate Symposium on Life Science, HKUST, Hong Kong, 9 June 2012. . 2012.

Hor H.H., Wang X., Hui C.C. and Sham M.H., Suppressor of fused (Su(fu)) Plays Domain Specific Function in Orchestrating The Maintenance and Differentiation of Hindbrain Neural Progenitor Pools, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Hor H.H., Wang X., Hui C.C. and Sham M.H., Suppressor of fused (Su(fu)) modulates hindbrain hedgehog signaling and neurogenesis, International Society of Developmental Neuroscience 2012: Neurodevelopment and Neurological Diseases, Mumbai, India, 11-14 January 2012.

Hor H.H., Wang X., Hui C.C. and Sham M.H., Suppressor of fused (Su(fu)) plays domain specific function in orchestrating the maintenance and differentiation of hindbrain neural progenitor pools, 2012 Inter-University Postgraduate Symposium on Life Science, HKUST, Hong Kong, 9 June 2012. . 2012.

Researcher : Hu J

List of Research Outputs

Feng C., Hu J., Chan C.W.W., Ng H.U.C.K. .H.U.I. and Chan D., Role of IHH signaling in the progression of digit joint formation, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Feng C., Stricker S., Hu J., Mundlos S., Hui N.H. and Chan D., Role of IHH signaling in the progression of joint formation in digit development, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Hu J., Li S. and Huang W., An Improved Method For Cell Traction Force Measurement, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Li S., Hu J., Liu C., Fu X., Huang J., Cui X. and Huang W., A Versatile Microscopy to Study Biological Pattern Formation, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Lu X., Li S., Hu J., Hwa T.E.R.R.Y., Huang J. and Huang W., Quantitative characterization of mouse embryonic stem cell self-renewal, differentiation and dedifferentiation, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Researcher : Hu J

List of Research Outputs

Researcher : Huang J

Project Title:	RNA-DNA hybrid oligonucleotide mediated site-specific repair and gene therapy
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Matching Fund for Hi-Tech Research and Development Program of China (863 Projects)
Start Date:	01/2003

Project Title:	Development of bacteria-mediated oral vaccine against highly pathogenic avian influenza viruses for veterinary use
Investigator(s):	Huang J, Yuen KY, Zheng B
Department:	Biochemistry
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	11/2007

Project Title:	Toward the treatment of breast cancer by targeting breast tumor initiating cells with microRNAs
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Travel Grants for NSFC/RGC JRS
Start Date:	12/2007

Project Title:	Toward a Bioshield against Influenza Virus Infection by Commensal Bacteria Secreting Antiviral Peptide
Investigator(s):	Huang J, Yuen KY, Zheng B
Department:	Biochemistry
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	12/2008

Project Title:	Toward the treatment of breast cancer by targeting breast tumor initiating cells with microRNAs
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	04/2009
Completion Date:	03/2012

Project Title:	Development of a Pan-organism Riboregulator Device
Investigator(s):	Huang J, Jin Y
Department:	Biochemistry
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	11/2009

Project Title:	Development of a Pan-organism Riboregulator Device
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	12/2009

Project Title:	Mechanistic study of the roles of kinesin-1 in myofibril assembly
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2011

Project Title:	Programming the Second Generation Tumor-targeting Bacteria
Investigator(s):	Huang J, Cui X, Man K
Department:	Biochemistry
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	03/2011

Project Title:	Mechanistic study of reprogramming epithelial cells to form mesenchymal stem cells
Investigator(s):	Huang J, Cui J
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2011
Completion Date:	03/2012

Project Title:	An auto-induction protein expression system
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	06/2012

Project Title:	Role of kinesin-1 in NMDAR trafficking and cerebral ischemia
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

List of Research Outputs

Chan H.M., Chen L., Liu M., Hu L., Zheng B., Poon K.M., Huang P., Yuan Y.F., Huang J., Yang J., Tsao G.S.W. and Guan X., Translationally controlled tumor protein induces mitotic defects and chromosome missegregation in hepatocellular carcinoma development. , Hepatology . 2012, 55: 491-505.

Fu X., Tang L.H., Liu C., Huang J., Hwa T. and Lenz P., Stripe Formation in Bacterial Systems with Density-Suppressed Motility, Physical Review Letters. New York, American Physical Society, 2012, 108: 198102:1-5.

Gan H., Zhu G., Xue W., Chan D., Cheah K.S.E. and Huang J., Kinesin-1 is necessary for cytokinesis in chondrocytes, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.. 2012.

Gan H., Zhu G., Xue W., Chan D., Cheah K.S.E. and Huang J., Kinesin-1 is necessary for cytokinesis in chondrocytes, Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012.. 2012.

Gan H., Zhu G., Xue W., Chan D., Cheah K.S.E. and Huang J., Roles of kinesin-1 mediated intracellular transport in skeletal development, Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012.. 2012.

Huang J. and Huang J., Applications of Synthetic Biology, Jiangnan University, Wuxi, China, July 19, 2011 . 2011.

Huang J., Autonomous formation of sequential periodic stripes from density-dependent motility, Marburg University and Max Planck Institute for Terrestrial Microbiology, Karl-von-Frisch Str. 10, 35043 Marburg, Germany, December 16, 2011 . 2011.

Huang J., Autonomous formation of sequential periodic stripes from density-dependent motility, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China, October 21, 2011 . 2011.

Huang J., Generation of sequential and periodic pattern by coupling cell motility with density, National Taiwan University College of Medicine (NTUCM), Taipei, Taiwan, China, August 8, 2011 . 2011.

Huang J., Program cell distribution in time and space: a synthetic biology approach, East China University of Science and Technology, Shanghai, China, May 10, 2012 . 2012.

Huang J., Program cell distribution in time and space: a synthetic biology approach, Institute of Plant Physiology & Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China, May 11, 2012 . 2012.

Huang J., Program cell distribution in time and space: a synthetic biology approach, Shanghai Jiaotong University, Shanghai, China, May 11, 2012 . 2012.

Huang J., Program cell distribution in time and space: a synthetic biology approach, Tianjian University, Tianjing, China, October 31, 2011 . 2011.

Huang J., Program cell distribution in time and space: a synthetic biology approach, Tsinghua University, Beijing, China, November 1, 2011 . 2011.

Huang J., Synthetic Biology Approach to Generate and Tune Sequential and Periodic Patterns, Division of Life Science, Hong Kong University of Science and Technology, Clear Water Bay, Hong Kong, June 8, 2012 . 2012.

Huang J., Synthetic biology approach to program cell distribution in time and space, Peking Union Medical College and the Chinese Academy of Medical Sciences, Beijing, China, December 31, 2011 . 2011.

Huang J., Synthetic biology approach to program cell distribution in time and space, Peking University, Beijing, China, December 29, 2011 . 2011.

Huang J., Synthetic biology approach to program cell distribution in time and space, Shandong University, Jinan, China, December 30, 2011 . 2011.

Jin Y. and Huang J., Engineering a portable riboswitch-LacP hybrid device for two-way gene regulation , Nucleic Acids Research. 2011.

Li S., Hu J., Liu C., Fu X., Huang J., Cui X. and Huang W., A Versatile Microscopy to Study Biological Pattern Formation, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Liu C., Fu X., Liu L., Ren X., Chau C.K.L., Li S., Xiang L., Zeng H., Chen G., Tang L.H., Lenz P., Cui X., Huang W., Hwa T. and Huang J., Sequential Establishment of Stripe Patterns in an Expanding Cell Population, Science. 2011, 334: 238-241.

Liu C., Fu X., Liu L., Ren X., Chau C.K., Li S., Xiang L., Zeng H., Chen G., Tang L.H., Lenz P., Cui X., Huang W., Hwa T.T. and Huang J., Sequential establishment of stripe patterns in an expanding cell population, Science. 2011, 334(6053): 238-41.

Lu S., Lu L.Y., Yuan Q.J., Sham M.H., Guan X. and Huang J., Cerebellar defects in Pdss2 conditional knockout mice during embryonic development and in adulthood, Neurobiology of Disease. 2011, 45: 219-233.

Lu X., Li S., Hu J., Hwa T.E.R.R.Y., Huang J. and Huang W., Quantitative characterization of mouse embryonic stem cell self-renewal, differentiation and dedifferentiation, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Shi L., Song E.W. and Huang J., Development of a trans-kingdom expression system in cancer therapy, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Yang M., Chen J., Su F., Yu B., Su F.X., Lin L., Liu Y.J., Huang J. and Song E.W., Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells, Molecular Cancer . 2011, 10(1): 117.

Yang W., Chen W., Wang H., Ho J.W.S., Huang J., Woo P.C.Y., Lau S.K.P., Yuen K.Y., Zhang Q., Zhou W., Bartlam M., Watt R.M. and Rao Z., Structural and functional insight into the mechanism of an alkaline exonuclease from Laribacter hongkongensis, Nucleic Acids Research. 2011, 39(22): 9803-19.

Yu B., Yang M., Shi L., Yao Y.D., Jiang Q.Q., Li X.F., Tang L.H., Zheng B., Yuen K.Y., Smith D.K., Song E.W. and Huang J., Explicit hypoxia targeting with tumor suppression by creating an "obligate" anaerobic Salmonella Typhimurium strain , Scientific Reports . 2012, 2: 436.

Yuan Q., Su H., Guo J., Tsang K.Y., Cheah K.S.E., Chiu K., Yang J., Wong W.M., So K.F., Huang J., Wu W. and Lin Z.X., Decreased c-jun expression correlates with impaired spinal motoneuron regeneration in aged mice following sciatic nerve crush, Experimental Gerontology. 2012, 47: 329-336.

Yuan Q.J., Su H., Guo J.S., Tsang K.Y., Cheah K.S.E., Chiu K.I.N., Yang J., Wong W.M., So K.F., Huang J., Wu W. and Lin Z.X., Decreased c-Jun expression correlates with impaired spinal motoneuron regeneration in aged mice following sciatic nerve crush., Exp Gerontol. Elsevier Inc., 2012, 47: 329-36.

Zhang K., Yu B., Cao T., Zhang N. and Huang J., A preliminary study for development of oral vaccines for poultry and wild birds against avian H5N1 influenza virus, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Researcher : Huang J.

Project Title:	RNA-DNA hybrid oligonucleotide mediated site-specific repair and gene therapy
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Matching Fund for Hi-Tech Research and Development Program of China (863 Projects)
Start Date:	01/2003

Project Title:	Development of bacteria-mediated oral vaccine against highly pathogenic avian influenza viruses for veterinary use
Investigator(s):	Huang J, Yuen KY, Zheng B
Department:	Biochemistry
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	11/2007

Project Title:	Toward the treatment of breast cancer by targeting breast tumor initiating cells with microRNAs
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Travel Grants for NSFC/RGC JRS
Start Date:	12/2007

Project Title:	Toward a Bioshield against Influenza Virus Infection by Commensal Bacteria Secreting Antiviral Peptide
Investigator(s):	Huang J, Yuen KY, Zheng B
Department:	Biochemistry
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	12/2008

Project Title:	Toward the treatment of breast cancer by targeting breast tumor initiating cells with microRNAs
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	04/2009
Completion Date:	03/2012

Project Title:	Development of a Pan-organism Riboregulator Device
Investigator(s):	Huang J, Jin Y
Department:	Biochemistry
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	11/2009

Project Title:	Development of a Pan-organism Riboregulator Device
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	12/2009

Project Title:	Mechanistic study of the roles of kinesin-1 in myofibril assembly
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2011

Project Title:	Programming the Second Generation Tumor-targeting Bacteria
Investigator(s):	Huang J, Cui X, Man K
Department:	Biochemistry
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	03/2011

Project Title:	Mechanistic study of reprogramming epithelial cells to form mesenchymal stem cells
Investigator(s):	Huang J, Cui J
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2011
Completion Date:	03/2012

Project Title:	An auto-induction protein expression system
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	06/2012

Project Title:	Role of kinesin-1 in NMDAR trafficking and cerebral ischemia
Investigator(s):	Huang J
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

List of Research Outputs

Researcher : Huang W

Project Title:	A quantitative platform to study the role of genes and small chemicals in embryonic stem cell self-renewal and reprogramming
Investigator(s):	Huang W, Huang J
Department:	Physics
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2010

Project Title:	Quantitative characterization of mouse embryonic stem cell self- renewal, differentiation and dedifferentiation
Investigator(s):	Huang W, Huang J
Department:	Physics
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2011

Project Title:	The geometry, dynamics and mechanics of mesenchymal cell pattern formation
Investigator(s):	Huang W
Department:	Physics
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2012

List of Research Outputs

Hu J., Li S. and Huang W., An Improved Method For Cell Traction Force Measurement, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Li S., Hu J., Liu C., Fu X., Huang J., Cui X. and Huang W., A Versatile Microscopy to Study Biological Pattern Formation, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Liu C., Fu X., Liu L., Ren X., Chau C.K.L., Li S., Xiang L., Zeng H., Chen G., Tang L.H., Lenz P., Cui X., Huang W., Hwa T. and Huang J., Sequential Establishment of Stripe Patterns in an Expanding Cell Population, Science. 2011, 334: 238-241.

Liu C., Fu X., Liu L., Ren X., Chau C.K., Li S., Xiang L., Zeng H., Chen G., Tang L.H., Lenz P., Cui X., Huang W., Hwa T.T. and Huang J., Sequential establishment of stripe patterns in an expanding cell population, Science. 2011, 334(6053): 238-41.

Lu X., Li S., Hu J., Hwa T.E.R.R.Y., Huang J. and Huang W., Quantitative characterization of mouse embryonic stem cell self-renewal, differentiation and dedifferentiation, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Researcher : Hui CC

List of Research Outputs

Hor H.H., Wang X., Hui C.C. and Sham M.H., Best Poster Award: Suppressor of fused (Su(fu)) plays domain specific function in orchestrating the maintenance and differentiation of hindbrain neural progenitor pools., 2012 Inter-University Postgraduate Symposium on Life Science, HKUST, Hong Kong, 9 June 2012. . 2012.

Hor H.H., Wang X., Hui C.C. and Sham M.H., Suppressor of fused (Su(fu)) Plays Domain Specific Function in Orchestrating The Maintenance and Differentiation of Hindbrain Neural Progenitor Pools, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Hor H.H., Wang X., Hui C.C. and Sham M.H., Suppressor of fused (Su(fu)) modulates hindbrain hedgehog signaling and neurogenesis, International Society of Developmental Neuroscience 2012: Neurodevelopment and Neurological Diseases, Mumbai, India, 11-14 January 2012.

Hor H.H., Wang X., Hui C.C. and Sham M.H., Suppressor of fused (Su(fu)) plays domain specific function in orchestrating the maintenance and differentiation of hindbrain neural progenitor pools, 2012 Inter-University Postgraduate Symposium on Life Science, HKUST, Hong Kong, 9 June 2012. . 2012.

Liu Y., Chu K.H., Hui C.C. and Sham M.H., Best Poster Award: The roles of Irx3 and Irx5 genes in mammalian inner ear development., 2012 Inter-University Postgraduate Symposium on Life Science, HKUST, Hong Kong, 9 June 2012. . 2012.

Liu Y., Hui C.C. and Sham M.H., The Irx3 and Irx5 genes in inner ear development, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Liu Y., Chu K.H., Hui C.C. and Sham M.H., The Roles of Irx3 and Irx5 Genes in Mammalian Inner Ear Development, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Liu Y., Chu K.H., Hui C.C. and Sham M.H., The roles of Irx3 and Irx5 genes inmammalian inner ear development, 2012 Inter-University Postgraduate Symposium on Life Science, HKUST, Hong Kong, 9 June 2012. . 2012.

Ngan E.S.W., Garcia-Barcelo M.M., Yip B.H.K., Poon P.C., Lau C.S.T., Kwok K.M., Sat E.W.Y., Sham M.H., Wong K.K.Y., Wainwright B.J., Cherny S.S., Hui C.C., Sham P.C., Lui V.C.H. and Tam P.K.H., Hedgehog/Notch-induced premature gliogenesis represents a new disease mechanism for Hirschsprung’s disease in mice and humans, Journal of Clinical Investigation. 2011, 121(9): 3467-3478.

Researcher : Hui MN

List of Research Outputs

Hui M.N., Wu M.H., Chan K.K. and Cheung M.C.H., Investigating the role of Sox9 in human neural stem cells, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Researcher : Ikegawa S

List of Research Outputs

Fan Y., Song Y., Chan D., Takahashi Y., Ikegawa S., Matsumoto M., Kou I., Cheah K.S.E., Sham P.C., Cheung K.M.C. and Luk K.D.K., SNP rs11190870 near LBX1 is associated with adolescent idiopathic scoliosis in southern Chinese., J Hum Genet . 2011, 57(4): 244-6.

Researcher : Jia Y

List of Research Outputs

Jia Y., Yu S.J. and Song Y., Computational construction of the downstream network of Pax6 in AD neuronal death model, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Researcher : Jin D

Project Title:	Mitotic checkpoint and genomic stability in ovarian cancer
Investigator(s):	Jin D
Department:	Biochemistry
Source(s) of Funding:	National Institutes of Health, US Department of Health and Human Services - General Award
Start Date:	09/2002

Project Title:	Roles for p21-activated protein kinase 3 in HTLV-I pathogenesis
Investigator(s):	Jin D, Ching YP
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2006

Project Title:	Outstanding Researcher Award 2007-2008
Investigator(s):	Jin D
Department:	Biochemistry
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	10/2008

Project Title:	Roles and regulation of MIP-T3 in centrosomal and ciliary function
Investigator(s):	Jin D, Ching YP, Kok KH
Department:	Biochemistry
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2009
Completion Date:	12/2011

Project Title:	Posttranslational modifications of TORC transcriptional coactivators and implications in HTLV-1 pathogenesis
Investigator(s):	Jin D
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2009
Completion Date:	12/2011

Project Title:	4th Intracellular Proteolysis Meeting on Ubiquitin-proteasome System, Dynamics and Targeting REV7-mediated polyubiquitination and degradation of human REV1
Investigator(s):	Jin D
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2009

Project Title:	Knockdown of miR-BART5 in Epstein-Barr Virus-infected Cells by RNA Decoys Delivered through Novel Adenoviral Vectors: a New Paradigm for Cancer Therapy
Investigator(s):	Jin D, Kok KH, Lei T
Department:	Biochemistry
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	01/2010

Project Title:	Identification and characterization of the cellular targets of miR-BART5, an Epstein-Barr virus-encoded microRNA
Investigator(s):	Jin D, Kok KH, Tsao GSW
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2010

Project Title:	Knockdown of miR-BART5 in Epstein-Barr Virus-infected Cells by RNA Decoys Delivered through Novel Adenoviral Vectors: a New Paradigm for Cancer Therapy
Investigator(s):	Jin D
Department:	Biochemistry
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	01/2010

Project Title:	Knockdown of miR-BART5 in Epstein-Barr Virus-infected Cells by RNA Decoys Delivered through Novel Adenoviral Vectors: a New Paradigm for Cancer Therapy
Investigator(s):	Jin D
Department:	Biochemistry
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	01/2010

Project Title:	Regulatory roles of dsRNA-binding proteins PACT and TRBP in antiviral innate immunity
Investigator(s):	Jin D, Kok KH
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2010
Completion Date:	02/2012

Project Title:	Roles of dsRNA-binding protein PACT in RIG-I dependent innate antiviral immunity
Investigator(s):	Jin D, Kok KH
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2010

Project Title:	Mapping of peptide sequence in swine-origin H1N1 influenza virus hemagglutinin associated with the induction of anti-ganglioside antibodies implicated in Guillain-Barre syndrome: a pilot study
Investigator(s):	Jin D, Zheng B
Department:	Biochemistry
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2011

Project Title:	Modulation of cell signalling by human coronavirus HKU1 S and M proteins
Investigator(s):	Jin D, Woo PCY
Department:	Biochemistry
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2011

Project Title:	Kinetochore localization and function of a structural component of the nuclear pore complex
Investigator(s):	Jin D
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2011

Project Title:	RIG-I and MDA5 agonists as vaccine adjuvants
Investigator(s):	Jin D, Kok KH
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	06/2011
Completion Date:	05/2012

Project Title:	Construction of miR-BART microRNA-deficient Epstein-Barr viruses in bacterial artificial chromosomes using recombineering in E. coli and characterization of recombinant viruses in nasopharyngeal epithelial cells
Investigator(s):	Jin D, Huang J
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2012

Project Title:	Subversion of host cellular organization and functions by pathogens Double stranded RNA-binding protein PACT counteracted by viruses is a cellular partner and activator of RIG-I and MDA5 in innate antiviral response
Investigator(s):	Jin D
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2012
Completion Date:	05/2012

Project Title:	Molecular mechanisms of innate antiviral response
Investigator(s):	Jin D, Kok KH, Lau ASY, Sham MH, Yuen KY, Zheng B
Department:	Biochemistry
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2012

List of Research Outputs

Chan C.P., Kok K.H. and Jin D., Activation of protein secretory pathway by fusion oncoprotein FUS-CREB3L2 in low-grade fibromyxoid sarcoma, 13th SCBA International Symposium of the Society of Chinese Bioscientists in America (SCBA), Guangzhou, China. 2011.

Chun C.S. and Jin D., REV7-mediated polyubiquitination and degradation of human DNA translesion synthesis polymerase REV1., Society of Chinese Bioscientists in America, 13th International Symposium, Guangzhou, China. 2011.

Kok K.H. and Jin D., A novel bunyavirus causing fever and thrombocytopenia: more questions than answers., Journal of the Formosan Medical Association. 2011, 110: 669-670.

Kong K.Y., Tang V.H.M., Jin D. and Wong C.M., Yeast Pre-mRNA splicing is facilitated by a RNA surveillance complex, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Kong K.Y., Tang H.M.V., Jin D. and Wong C.M., Yeast TRAMP complex facilitates pre-mRNA splicing, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Lai W.L., Hung W.Y., Wong L.L.Y., Zhou Y., Leong V.Y.L., Lee M.F., Ng I.O.L., Jin D. and Ching Y.P., The centrosomal protein Tax1 binding protein 2 is a novel tumour suppressor in hepatocellular carcinoma regulated by cyclin-dependent kinase 2, Hepatology. 2012, 56(5) pp: 1770-1781.

Lam H.C., Cherny S.S., Wong E.H.M., Sham P.C., Jin D. and Song Y., Functional characterisation reveals PTPN21 as a positive mediator of NRG3, a potential risk factor in Schizophrenia , 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Lei T., Siu K.L., Kok K.H., Chan K.H., Chan E.Y.T., Hung I.F.N., To K.K.W., Li P.C.K., Zhou J., Zheng B., Yuen K.Y., Wang M. and Jin D., Anti-ganglioside antibodies were not detected in human subjects infected with or vaccinated against 2009 pandemic influenza A (H1N1) virus., Vaccine. 2012, 30: 2605-2610.

Liu B., Jin D. and Zhou Z., From loss to gain: role for SUN1 in laminopathies, Cell & Bioscience. 2012, 2: 21.

Liu X., Jin D., McManus M.T. and Mourelatos Z., Precursor microRNA-programmed silencing complex assembly pathways in mammals., Molecular Cell. 2012, 46: 507-517.

Lui P.Y., Kok K.H. and Jin D., PACT, a double-stranded RNA binding protein, as cellular activator of cytoplasmic viral sensor MDA5, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Lui P.Y., Kok K.H. and Jin D., The double-stranded RNA-binding protein PACT is a cellular activator of MDA5 in innate antiviral immune response, 13th Biennial Meeting of the Society of Chinese Bioscientists in America (SCBA). 2011.

Ng M.H., Ho T.H., Kok K.H., Siu K.L., Li J. and Jin D., MIP-T3 is a negative regulator of innate type I interferon response., J Immunol. 2011, 184: 6473-6482.

Ng M.H., Ho T.H., Siu K.L., Kok K.H. and Jin D., ROLES OF MITOCHONDRIAL TRAFFICKING PROTEINS IN TYPE-I INTERFERON PRODUCTION, 13th International Symposium of the Society of Chinese Bioscientists in America. 2011.

Tang V.H.M., Siu Y.T., Chan C.P., Ching Y.P., Kok K.H. and Jin D., LKB1 tumor suppressor is a negative regulator of Tax-mediated transcriptional activation of human T-cell leukemia virus type 1 long terminal repeats, 13th SCBA International Symposium. Society of Chinese Bioscientists in America (SCBA). Guangzhou, China. 2011.

Tang V.H.M., Siu Y.T., Chan C.P., Kok K.H. and Jin D., STK11 inhibits transcriptional activation of HTLV-I LTR by Tax transactivator, The 70th Annual Meeting of the Japanese Cancer Association (JCA). 2011.

Wong K.Y., Yim R.L.H., So J.C.C., Jin D., Liang R.H.S. and Chim J.C.S., Epigenetic Inactivation of the MIR34B/C in Multiple Myeloma/ Best Abstract, 3rd International Hematologic Malignancies Conference/ The Asia Pacific Hematology Society. 2012.

Wong K.Y., Yim R.L.H., So J.C.C., Jin D., Liang R.H.S. and Chim J.C.S., Epigenetic Inactivation of the MIR34B/C in Multiple Myeloma, Blood. 2011, 118: 5901-5904.

Woo P.C.Y., Lau S.K.P., Choi K.Y., Huang Y., Teng L.L., Tsoi H.W., Tse H., Yeung M.L., Chan K.H., Jin D. and Yuen K.Y., Natural occurrence and characterization of two IRES elements in a novel virus, canine picodicistrovirus, in the picornavirus-like superfamily, Journal of Virology. 2011, 86: 2797-2808.

Yuen K.S., Tang V.H.M., Kok K.H. and Jin D., Adenoviral delivery of RNA decoys restores expression of proapoptotic protein PUMA in Nasopharyngeal carcinoma cell by silencing of epstein-barr virus-encoded antiapoptotic miR-BART5, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Researcher : Jin G

Project Title:	MT1-MMP in the regulation of stem cell niches
Investigator(s):	Jin G, Zhou Z
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	09/2010

List of Research Outputs

Chan J.K.M., Wong H.L.X., Jin G., Liu B., Cao R., Cao Y., Lehti K., Tryggvason K. and Zhou Z., MT1-MMP Inactivates ADAM9 to Regulate FGFR2 Signaling and Calvarial Osteogenesis, Developmental Cell. 2012, 22: 1176-1190.

Chan K.M.J., Wong H.L.X., Jin G., Cao R., Cao Y., Lehti K. and Zhou Z., MT1-MMP Inactivates ADAM9 to Regulate FGFR2 Signaling in Calvarial Osteogenesis. , Developmental Cell . Cell Press, 2012, 22 (6): 1176-1190.

Researcher : Jin G

List of Research Outputs

Researcher : Jin Y

Project Title:	Cell-to-cell coupling mediated seamless genetic engineering
Investigator(s):	Jin Y, Huang J
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	07/2010

List of Research Outputs

Jin Y. and Huang J., Engineering a portable riboswitch-LacP hybrid device for two-way gene regulation , Nucleic Acids Research. 2011.

Researcher : Kao PYP

List of Research Outputs

Chen L., Kao P.Y.P., Fan Y., Ho D.T.Y., Yik P.Y., Ha C.T., Chu L.W. and Song Y., Association between CLU Polymorphisms and clinical phenotypes in Alzheimer’s Disease, Alzheimer's Association International Conference (AAIC) . 2011.

Chen L., Kao P.Y.P., Fan Y., Ho T.Y., Yik P.Y., Ha C.T.J., Chu L.W. and Song Y., Polymorphisms of CR1, CLU and PICALM confer susceptibility of Alzheimer's disease in a southern Chinese population , Neurobiol Aging. 2012, 33(1):210.e: 1-7.

Chen L., Kao P.Y.P., Fan Y., Chu L.W. and Song Y., The genetic polymorphisms in sex steroid metabolic pathway and risk for sporadic Alzheimer's disease, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Kao P.Y.P., Chan D., Samartzis D., Sham P.C. and Song Y., Genetics of lumbar disk degeneration: technology, study designs, and risk factors, Orthop Clin North Am. 2011, 42(4): 479-86.

Kelempisioti A., Eskola P.J., Okuloff A., Karjalainen U., Takatalo J., Daavittila I., Niinimaki J., Sequeiros R.B., Tervonen O., Solovieva S., Kao P.Y.P., Song Y., Cheung K.M.C., Chan D., Ala-Kokko L., Jarvelin M.R., Karppinen J. and Mannikko M., Genetic susceptibility of intervertebral disc degeneration among young Finnish adults, BMC Medical Genetics. 2011, 12: 153.

Researcher : Kao YPP

List of Research Outputs

Yan C.H., Qiu Y., Chiu P.K.Y., Cheung K.M.C., Chan D., Kao Y.P.P. and Ng F.Y., Interleukin-1 Beta (il-1b) And Osteoprotegerin (opg) Gene Polymorphisms Are Associated With Knee Osteoarthritis In Chinese, Orthopaedic Basic Science Award, 31st Hong Kong Orthopaedic Association Annual Congress 2011. 2011.

Yan C.H., Qiu Y., Chiu P.K.Y., Cheung K.M.C., Chan D., Kao Y.P.P. and Ng F.Y., Osteoprotegerin (opg) And Interleukin-1 Beta (il-1b) Gene Polymorphisms Are Associated With Knee Osteoarthritis In Chinese, 6th International Congress Of Chinese Orthopaedic Association. 2011.

Yan C.H., Qiu Y., Chiu P.K.Y., Cheung K.M.C., Chan D., Kao Y.P.P. and Ng F.Y., The Association of Osteoprotegerin Gene Polymorphism with Knee Osteoarthritis in Chinese Population, 34th Singaporean Orthopaedic Association Annual Scientific Meeting. 2011.

Researcher : Kinghorn AB

List of Research Outputs

Tanner J.A., Kinghorn A.B. and Cheung Y.W., Nucleic Acid Aptamers for Sensing Applications – Aptamers for Diagnosing Malaria, EnGENEious, Oxford University, UK . 2012.

Researcher : Kok KH

Project Title:	Dominant negative role of a naturally-occurring alternatively spliced variant of TAR-binding protein in miRNA-mediated gene silencing
Investigator(s):	Kok KH
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2011

Project Title:	Inhibition of RIG-I-dependent innate immunity by herpes simplex virus type 1 Us11 protein
Investigator(s):	Kok KH, Jin D
Department:	Biochemistry
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2011

Project Title:	Characterization of the interferon-antagonizing activity of NSs protein encoded by severe febrile and thrombocytopenic syndrome virus (SFTSV), a newly identified phlebovirus associated with an emerging infectious disease
Investigator(s):	Kok KH
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2012

Project Title:	Modulation of RIG-I virus sensor by an Esptein-Barr virus-encoded microRNA
Investigator(s):	Kok KH, Jin D
Department:	Biochemistry
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2012

Project Title:	Identification of a novel splice isoform of TRBP and characterization of its role in microRNA biogenesis
Investigator(s):	Kok KH, Wong CM
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2012

Project Title:	EMBL Symposium: New Perspectives on Immunity to Infection The double-stranded RNA-binding protein PACT augments MDA5-mediated interferon production
Investigator(s):	Kok KH
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2012
Completion Date:	05/2012

List of Research Outputs

Chan C.P., Kok K.H. and Jin D., Activation of protein secretory pathway by fusion oncoprotein FUS-CREB3L2 in low-grade fibromyxoid sarcoma, 13th SCBA International Symposium of the Society of Chinese Bioscientists in America (SCBA), Guangzhou, China. 2011.

Kok K.H. and Jin D., A novel bunyavirus causing fever and thrombocytopenia: more questions than answers., Journal of the Formosan Medical Association. 2011, 110: 669-670.

Lei T., Siu K.L., Kok K.H., Chan K.H., Chan E.Y.T., Hung I.F.N., To K.K.W., Li P.C.K., Zhou J., Zheng B., Yuen K.Y., Wang M. and Jin D., Anti-ganglioside antibodies were not detected in human subjects infected with or vaccinated against 2009 pandemic influenza A (H1N1) virus., Vaccine. 2012, 30: 2605-2610.

Lui P.Y., Kok K.H. and Jin D., PACT, a double-stranded RNA binding protein, as cellular activator of cytoplasmic viral sensor MDA5, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Lui P.Y., Kok K.H. and Jin D., The double-stranded RNA-binding protein PACT is a cellular activator of MDA5 in innate antiviral immune response, 13th Biennial Meeting of the Society of Chinese Bioscientists in America (SCBA). 2011.

Ng M.H., Ho T.H., Kok K.H., Siu K.L., Li J. and Jin D., MIP-T3 is a negative regulator of innate type I interferon response., J Immunol. 2011, 184: 6473-6482.

Ng M.H., Ho T.H., Siu K.L., Kok K.H. and Jin D., ROLES OF MITOCHONDRIAL TRAFFICKING PROTEINS IN TYPE-I INTERFERON PRODUCTION, 13th International Symposium of the Society of Chinese Bioscientists in America. 2011.

Tang V.H.M., Siu Y.T., Chan C.P., Ching Y.P., Kok K.H. and Jin D., LKB1 tumor suppressor is a negative regulator of Tax-mediated transcriptional activation of human T-cell leukemia virus type 1 long terminal repeats, 13th SCBA International Symposium. Society of Chinese Bioscientists in America (SCBA). Guangzhou, China. 2011.

Tang V.H.M., Siu Y.T., Chan C.P., Kok K.H. and Jin D., STK11 inhibits transcriptional activation of HTLV-I LTR by Tax transactivator, The 70th Annual Meeting of the Japanese Cancer Association (JCA). 2011.

Yuen K.S., Tang V.H.M., Kok K.H. and Jin D., Adenoviral delivery of RNA decoys restores expression of proapoptotic protein PUMA in Nasopharyngeal carcinoma cell by silencing of epstein-barr virus-encoded antiapoptotic miR-BART5, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Researcher : Kong KY

List of Research Outputs

Kong K.Y., Tang V.H.M., Jin D. and Wong C.M., Yeast Pre-mRNA splicing is facilitated by a RNA surveillance complex, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Kong K.Y., Tang H.M.V., Jin D. and Wong C.M., Yeast TRAMP complex facilitates pre-mRNA splicing, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Researcher : Krishnan V

List of Research Outputs

Krishnan V., Liu B. and Zhou Z., 'Relax and Repair' to restrain aging, Aging. 2011, 3(10): 943-954.

Krishnan V., Liu B. and Zhou Z., DNA Repair, Human Diseases and Aging , In: Sonya Vengrova, DNA Repair and Human Health . INTECH, 2011, 1-40.

Krishnan V., Chow M.Z.Y., Wang Z., Zhang L., Liu X. and Zhou Z., Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice, Proc Natl Aca Sci USA. 2011, 108: 12325-30.

Researcher : Kudelko MA

List of Research Outputs

Brault J.B., Kudelko M.A., Vidalain P.O., Tangy F., Despres P. and Pardigon N., The interaction of flavivirus M protein with light chain Tctex-1 of human dynein plays a role in late stages of virus replication., Virology. 2011, 417 (2): 369-378.

Kudelko M.A., Brault J.B., Kwok K.T.H., Pardigon N., Peiris J.S.M., Bruzzone R., Despres P., Nal-Rogier B.T.M. and Wang P., Class II ADP-ribosylation Factors Are Required for Efficient Secretion of Dengue Viruses, The Journal of Biological Chemistry. 2012, 287 (1): 767-777.

Researcher : Kwok JC

List of Research Outputs

Kwok J.C., Yuen Y.L., Lau W.K., Zhang F.X., Fawcett J.W., Chan Y.S. and Shum D.K.Y., Chondroitin sulfates in the developing rat hindbrain confine commissural projections of vestibular nuclear neurons, Neural Development 7: art. 6. 2012.

Researcher : Kwok LF

List of Research Outputs

Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Activity assays of Chondroitinase ABCI immobilized on chitosan beads, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Immobilization Of Chondroitinase ABCI On Chitosan Beads To Improve Axonal Regrowth In Cspg-enriched Astrocyte Culture, Hong Kong-Taiwan Physiology Symposium 2012 and Joint Scientific Meeting of Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong, P62. 2012.

Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Immobilization of chondroitinase ABCI on chitosan beads to improve axonal regrowth in CSPG-enriched astrocyte culture, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 75. 2012.

Researcher : Kwong WH

Project Title:	The role of Smad4 in cochlear development in mouse
Investigator(s):	Kwong WH, Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	12/2011

Researcher : Lam HC

List of Research Outputs

Lam H.C., Cherny S.S., Wong E.H.M., Sham P.C., Jin D. and Song Y., Functional characterisation reveals PTPN21 as a positive mediator of NRG3, a potential risk factor in Schizophrenia , 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Researcher : Lam VMS

Project Title:	18th International Congress of Biochemistry and Molecular Biology Beyond the Human Glucose-6-phosphate Dehydrogenase (G6PD) Gene: Protein Structure and Function Analyses
Investigator(s):	Lam VMS
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2000

Project Title:	HUGO's Seventh International Human Genome Meeting, HGM2002 Post-Genomic Glucose-6-phosphate Dehydrogenase (G6PD): Different Mechanisms for Enzyme Deficiency from Structural and Kinetic Analyses
Investigator(s):	Lam VMS
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2002

Project Title:	7th International Symposium on Mutations in the Human Genome Multiplex Detection: a Rapid and Reliable Method to Screen Common Variations in the Glucose-6-phosphate Dehydrogenase Gene
Investigator(s):	Lam VMS
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2003

Researcher : Lam YL

List of Research Outputs

Lam Y.L., Cham W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Involvement of proheparanase and peri-synaptic heparan sulfate proteoglycan in synaptic plasticity to regulate AMPA-Type glutamate receptor trafficking, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Lam Y.L., Cham W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Modulation of synaptic plasticity by the partnership of proheparanase with peri-synaptic heparan sulfate proteoglycan and AMPA-type glutamate receptor, Abstracts of 7th Int’l Symp. on Healthy Aging: 73. 2012.

Lam Y.L., Cham W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Proheparanase-mediated AMPA-type glutamate receptor regulation in synaptic plasticity, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Lam Y.L., Cham W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Regulation of AMPA-type glutamate receptor trafficking by proheparanase in synaptic plasticity, Society Neuroscience Abstract (USA), 870.09/D41. 2011.

Lam Y.L., Cham W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Regulatory role of proheparanase with peri-synaptic heparan sulfate proteoglycan and AMPA-type glutamate receptor in synaptic plasticity, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 73. 2012.

Researcher : Lee KS

List of Research Outputs

Lee K.S., Lam T.K., Cheah K.S.E., Cheung K.M.C. and Chan D., In vivo study of Asporin, a genetic risk factor for intervertebral disc degeneration, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Researcher : Lei IL

List of Research Outputs

Lei I.L., Sham M.H. and Wang Z., ATP-dependent chromatin remodeling complex SWI/SNF in cardiogenesis and cardiac progenitor cell development., Frontiers in biology. 2012, 7(3): 202-211.

Lei I.L., Gao X., Sham M.H. and Wang Z., SWI/SNF component BAF250a regulates cardiac progenitor cell differentiation by modulating chromatin accessibility during second heart field development., Journal of Biological Chemistry. 2012, Epub ahead of print.

Researcher : Lei IL

List of Research Outputs

Lei I.L., Sham M.H. and Wang Z., ATP-dependent chromatin remodeling complex SWI/SNF in cardiogenesis and cardiac progenitor cell development., Frontiers in biology. 2012, 7(3): 202-211.

Researcher : Lei T

Project Title:	A→I editing of Epstein-Barr virus-encoded BART microRNAs and its impact on microRNA biogenesis
Investigator(s):	Lei T, Jin D
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2009

List of Research Outputs

Lei T., Siu K.L., Kok K.H., Chan K.H., Chan E.Y.T., Hung I.F.N., To K.K.W., Li P.C.K., Zhou J., Zheng B., Yuen K.Y., Wang M. and Jin D., Anti-ganglioside antibodies were not detected in human subjects infected with or vaccinated against 2009 pandemic influenza A (H1N1) virus., Vaccine. 2012, 30: 2605-2610.

Researcher : Leung C

List of Research Outputs

Leung C., Chan S.C.L., Tsang S.L., Wu W. and Sham M.H., Cyb26b1 mediates differential regulation of RA signaling in neural progenitor populations along the anterior-posterior axis of the adult spinal cord, Days of Molecular Medicine 2011, Re-engineering Regenerative Medicine, Hong Kong, 10-12 November 2011.

Leung C., Chan S.C.L., Tsang S.L., Wu W. and Sham M.H., Cyp26b mediates differential neurogenicity in axial-specific populations of adult spinal cord progenitor cells., Stem Cells and Development. 2012, Epub ahead of print.

Zhang M., Leung C., Sit H.M., Chu K.H., Lui V.C.H., Tam P.K.H. and Sham M.H., Sox10 ^NGFP mutation affects migration of enteric neural cress cells in mouse embryonic gut, The 3rd International Symposium on Development of the Enteric Nervous System Cells, Signals and Genes, Hong Kong, 25-28 March, 2012.

Researcher : Leung HY

List of Research Outputs

Leung H.Y., Tsui Y.P., Shea G.K.H., Tai W.Y.E., Chan Y.S. and Shum D.K.Y., Involvement of Neuregulin 1 Type III in the Ex Vivo Generation of Fate Committed Schwann Cells from Bone Marrow Stromal Cells, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Leung H.Y., Tsui Y.P., Shea G.K.H., Tai W.Y.E., Chan Y.S. and Shum D.K.Y., Role of neuregulin 1 type III in the generation of fate committed Schwann cells from bone marrow stromal cells, Abstracts of 7^th Int’l Symp. on Healthy Aging: Live Well, Age Well : 66. 2012.

Leung H.Y., Tsui Y.P., Shea G.K.H., Tai W.Y.E., Chan Y.S. and Shum D.K.Y., Signal involved in the switch to fate commitment of bone marrow-derived Schwann cells, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 74. 2012.

Shum D.K.Y., Tai W.Y.E., Shea G.K.H., Leung H.Y. and Chan Y.S., Roles of notch and ErbB signaling in the fate commitment of bone marrow-derived Schwann cells, Proc. 8th IBRO World Congress of Neuroscience: B077 [Florence Italy July 14-18, 2011] . 2011.

Tai W.Y.E., Shea G.K.H., Leung H.Y., Chan Y.S. and Shum D.K.Y., Mechanism behind the fate commitment of bone marrow-derived schwann cells, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Tai W.Y.E., Shea G.K.H., Tsui Y.P., Leung H.Y., Chan Y.S. and Shum D.K.Y., Notch signaling mediates the switch to fate commitment of bone marrow-derived Schwann cells, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 74. 2012.

Tai W.Y.E., Shea G.K.H., Tsui Y.P., Leung H.Y., Tam K.W., Chan Y.S. and Shum D.K.Y., Signals Involved In The Switch To Fate Commitment Of Bone Marrow-derived Schwann Cells, Seventh International Symposium on Healthy Aging, P45. 2012.

Researcher : Leung HY

List of Research Outputs

Researcher : Leung KKH

List of Research Outputs

Ho B.S.-.Y., Cheng C.C.W., Leung K.K.H., Koopman P. and Cheah K.S.E., The role of Sox2 in mouse hair morphogenesis, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Leung Y.L., Gao B., Leung K.K.H., Melhado I.G., Wynn S.L., Au Y.K., Dung W.F., Lau J.Y.B., Mak A.C.Y., Chan D. and Cheah K.S.E., Sox9 governs differentiation stage-specific gene expression in growth plate chondrocytes via direct concomitant transactivation and repression., PLoS Genetics. 2011, 7(11): e1002356.

Wang C., Tan Z., Tsang K.Y., Leung K.K.H., Ron D., Chan D. and Cheah K.S.E., The Role of PERK Pathway in adaptation of Hypertrophci Chondrocytes to ER Stress. , Joint Meeting of The 45th Annual Meeting of the Japanese Society of Developmental Biologists & The 64th Annual Meeting of the Japan Society for Cell Biology , Kobe, Japan, May 28-31, 2012 . 2012.

Wang C., Tan Z., Tsang K.Y., Leung K.K.H., Chan D. and Cheah K.S.E., (The Best Poster Award) The role of PERK pathway in adaptation of hypertrophic condrocytes to ER stress, Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012.. 2012.

Wang C., Tan Z., Tsang K.Y., Leung K.K.H., Chan D. and Cheah K.S.E., The role of PERK pathway in adaptation of hypertrophic chondrocytes to ER stress, Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012.. 2012.

Researcher : Leung WYG

List of Research Outputs

Shiu S.Y.W., Leung W.Y.G., Tam C.W., Liu V.W.S. and Yao K.M., Melatonin MT(1) receptor-induced transcriptional up-regulation of p27(Kip1) in prostate cancer antiproliferation is mediated via inhibtion of constitutively active nuclear factor kappa B (NF-kB): potential implications on prostate cancer chemoprevention and therapy, J Pineal Res. 2012, 54 (Jan 2013): 69-79.

Researcher : Li J

List of Research Outputs

Li J., Wang P., Liu X., Lim E.L., Wang Z., Yeager M., Wong M.P., Sham P.C., Chanock S.J. and Wang J.J., GWASdb: a database for human genetic variants identified by genome-wide association studies, Nucleic Acids Res. 2011, 40(Database issue): D1047-54.

Qin J., Li J., Wang P., Zhang M.Q. and Wang J.J., ChIP-Array: Gene Regulation Network Construction from ChIP-seq/chip and mRNA expression data, The Fifth IEEE International Conference on Systems Biology, Zhuhai, China, 2-4 September 2011.

Qin J., Li J. and Wang J.J., ProteoMir express: inferring microRNA activities from mRNA and protein expression data, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Wang J.J. and Li J., FastPval: a fast and memory efficient program to calculate very low P-values from empirical distribution, IEEE International Conference on Systems Biology, Zhuhai, China, Sept 2- 4. 2011.

Wang Y., Wang P., Li J., Qin J., Wang X.W., Zhang M.Q. and Wang J.J., EpiRegNet: constructing epigenetic regulatory network from high throughput gene expression data for humans, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Wang Y., Wang P., Li J., Qin J., Wang X.W., Zhang M.Q. and Wang J.J., EpiRegNet: constructing epigenetic regulatory network from high throughput gene expression data for humans, Bioinformatics of Human and Animal Genomics, Cold Spring Harbor Asia, Suzhou, China, 14-18 November 2011.

Wang Y., Wang P., Li J., Qin J., Wang X.W., Zhang M.Q. and Wang J.J., EpiRegNet: constructing epigenetic regulatory network from high throughput gene expression data for humans, The Fifth IEEE International Conference on Systems Biology, Zhuhai, China, 2-4 September 2011.

Wang Y., Wang P., Li J., Qin J., Wang X.W., Zhang M.Q. and Wang J.J., EpiRegNet: constructing epigenetic regulatory networks from high throughput gene expression data for human., Epigenetics. 2011, 6(12): 1505-12.

Researcher : Li J

List of Research Outputs

Qin J., Li J. and Wang J.J., ProteoMir express: inferring microRNA activities from mRNA and protein expression data, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Wang Y., Wang P., Li J., Qin J., Wang X.W., Zhang M.Q. and Wang J.J., EpiRegNet: constructing epigenetic regulatory network from high throughput gene expression data for humans, Bioinformatics of Human and Animal Genomics, Cold Spring Harbor Asia, Suzhou, China, 14-18 November 2011.

Wang Y., Wang P., Li J., Qin J., Wang X.W., Zhang M.Q. and Wang J.J., EpiRegNet: constructing epigenetic regulatory network from high throughput gene expression data for humans, The Fifth IEEE International Conference on Systems Biology, Zhuhai, China, 2-4 September 2011.

Researcher : Li Y

List of Research Outputs

Wang J., Chen L., Li Y. and Guan X., Overexpression of cathepsin Z contributes to tumor metastasis by inducing epithelial-mesenchymal transition in hepatocellular carcinoma. , PLoS One. 2011, 6(9): e24967.

Researcher : Lim EL

List of Research Outputs

Li J., Wang P., Liu X., Lim E.L., Wang Z., Yeager M., Wong M.P., Sham P.C., Chanock S.J. and Wang J.J., GWASdb: a database for human genetic variants identified by genome-wide association studies, Nucleic Acids Res. 2011, 40(Database issue): D1047-54.

Researcher : Liu B

Project Title:	Adult stem cell decline accelerates premature ageing in Zmpste24 deficient mice
Investigator(s):	Liu B, Zhou Z
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	08/2008

Project Title:	Stem Cells 2009 Oxidative stress-mediated accelerated adult stem cell decline contributes to premature ageing in Zmpste24–/– mice
Investigator(s):	Liu B
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2009

Project Title:	Quantitative mass spectrometry-based screening for SIRT1 deacetylating targets
Investigator(s):	Liu B, Zhou Z, Chu IK
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2012

List of Research Outputs

Chan J.K.M., Wong H.L.X., Jin G., Liu B., Cao R., Cao Y., Lehti K., Tryggvason K. and Zhou Z., MT1-MMP Inactivates ADAM9 to Regulate FGFR2 Signaling and Calvarial Osteogenesis, Developmental Cell. 2012, 22: 1176-1190.

Kar B., Liu B., Zhou Z. and Lam Y.W., Quantitative nucleolar proteomics reveals nuclear re-organization during stress-induced senescence in mouse fibroblast. , BMC Cell Biology . 2011.

Krishnan V., Liu B. and Zhou Z., 'Relax and Repair' to restrain aging, Aging. 2011, 3(10): 943-954.

Krishnan V., Liu B. and Zhou Z., DNA Repair, Human Diseases and Aging , In: Sonya Vengrova, DNA Repair and Human Health . INTECH, 2011, 1-40.

Liu B., Jin D. and Zhou Z., From loss to gain: role for SUN1 in laminopathies, Cell & Bioscience. 2012, 2: 21.

Researcher : Liu C

Project Title:	Evolution of a synthetic pattern formation system
Investigator(s):	Liu C, Huang J
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	06/2012

Project Title:	SMBE Conference 2012 Pattern formation and evolution by engineered bacteria
Investigator(s):	Liu C
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2012

List of Research Outputs

Fu X., Tang L.H., Liu C., Huang J., Hwa T. and Lenz P., Stripe Formation in Bacterial Systems with Density-Suppressed Motility, Physical Review Letters. New York, American Physical Society, 2012, 108: 198102:1-5.

Li S., Hu J., Liu C., Fu X., Huang J., Cui X. and Huang W., A Versatile Microscopy to Study Biological Pattern Formation, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Liu C., Dr KP Stephen Chang Gold Medal , Li Ka Shing Faculty of Medicine, HKU. 2011.

Liu C., Fu X., Liu L., Ren X., Chau C.K.L., Li S., Xiang L., Zeng H., Chen G., Tang L.H., Lenz P., Cui X., Huang W., Hwa T. and Huang J., Sequential Establishment of Stripe Patterns in an Expanding Cell Population, Science. 2011, 334: 238-241.

Liu C., Fu X., Liu L., Ren X., Chau C.K., Li S., Xiang L., Zeng H., Chen G., Tang L.H., Lenz P., Cui X., Huang W., Hwa T.T. and Huang J., Sequential establishment of stripe patterns in an expanding cell population, Science. 2011, 334(6053): 238-41.

Researcher : Liu C

List of Research Outputs

Liu C., Dr KP Stephen Chang Gold Medal , Li Ka Shing Faculty of Medicine, HKU. 2011.

Researcher : Liu L

List of Research Outputs

Liu C., Fu X., Liu L., Ren X., Chau C.K.L., Li S., Xiang L., Zeng H., Chen G., Tang L.H., Lenz P., Cui X., Huang W., Hwa T. and Huang J., Sequential Establishment of Stripe Patterns in an Expanding Cell Population, Science. 2011, 334: 238-241.

Liu C., Fu X., Liu L., Ren X., Chau C.K., Li S., Xiang L., Zeng H., Chen G., Tang L.H., Lenz P., Cui X., Huang W., Hwa T.T. and Huang J., Sequential establishment of stripe patterns in an expanding cell population, Science. 2011, 334(6053): 238-41.

Researcher : Liu L

List of Research Outputs

Researcher : Liu X

List of Research Outputs

Li J., Wang P., Liu X., Lim E.L., Wang Z., Yeager M., Wong M.P., Sham P.C., Chanock S.J. and Wang J.J., GWASdb: a database for human genetic variants identified by genome-wide association studies, Nucleic Acids Res. 2011, 40(Database issue): D1047-54.

Researcher : Liu Y

List of Research Outputs

Liu Y., Chu K.H., Hui C.C. and Sham M.H., Best Poster Award: The roles of Irx3 and Irx5 genes in mammalian inner ear development., 2012 Inter-University Postgraduate Symposium on Life Science, HKUST, Hong Kong, 9 June 2012. . 2012.

Liu Y., Hui C.C. and Sham M.H., The Irx3 and Irx5 genes in inner ear development, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Liu Y., Chu K.H., Hui C.C. and Sham M.H., The Roles of Irx3 and Irx5 Genes in Mammalian Inner Ear Development, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Liu Y., Chu K.H., Hui C.C. and Sham M.H., The roles of Irx3 and Irx5 genes inmammalian inner ear development, 2012 Inter-University Postgraduate Symposium on Life Science, HKUST, Hong Kong, 9 June 2012. . 2012.

Researcher : Lovell-Badge RH

List of Research Outputs

Matheu A., Collado M., Wise C., Manterola I., Cekaite L., Tye A.J., Canamero M., Bujanda L., Schedl A., Cheah K.S.E., Skotheim R.I., Lothe R.A., Lopez de Munain A., Briscoe J., Serrano M. and Lovell-Badge R.H., Oncogenicity of the Developmental Transcription Factor Sox9. , Cancer Research . 2012, 72: 1301-1315.

Researcher : Lu L

List of Research Outputs

Wang Y., Lu L., Wu M.H., Chan D., Cheah K.S.E. and Cheung M.C.H., Generation of induced pluripotent stem (iPS) cells from bone- formating cells, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Wang Y., Lu L., Wu M.H., Sham M.H., Chan D., Cheah K.S.E. and Cheung K.M.C., Induction of osteo-chondroprogenitors formation during transcription factor-mediated reprogramming processes, 10th Annual Meeting of International Society for Stem Cell Research, Yokohama, Japan. Jun 13-16 2012.. 2012.

Researcher : Lu L

List of Research Outputs

Researcher : Lu S

List of Research Outputs

Lu S., Lu L.Y., Yuan Q.J., Sham M.H., Guan X. and Huang J., Cerebellar defects in Pdss2 conditional knockout mice during embryonic development and in adulthood, Neurobiology of Disease. 2011, 45: 219-233.

Researcher : Lu X

List of Research Outputs

Lu X., Li S., Hu J., Hwa T.E.R.R.Y., Huang J. and Huang W., Quantitative characterization of mouse embryonic stem cell self-renewal, differentiation and dedifferentiation, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Researcher : Lui PY

List of Research Outputs

Lui P.Y., Kok K.H. and Jin D., PACT, a double-stranded RNA binding protein, as cellular activator of cytoplasmic viral sensor MDA5, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Lui P.Y., Kok K.H. and Jin D., The double-stranded RNA-binding protein PACT is a cellular activator of MDA5 in innate antiviral immune response, 13th Biennial Meeting of the Society of Chinese Bioscientists in America (SCBA). 2011.

Researcher : Lui PY

List of Research Outputs

Researcher : Lui WT

List of Research Outputs

Lui W.T. and Wong N.S., Functional significance of the 3'-UTR in the mRNA of the stress-inducible protein CHOP/Gadd153, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Researcher : Mak ACY

List of Research Outputs

Cheah K.S.E., Szeto Y.Y., Au Y.K., Wynn S., Mak A.C.Y., Chan Y.S., Lovell-Badge R., Chan W.Y. and Fritzsch B., Defects in cochlear structure and function in the Sox9Y440X campomelic dysplasia mouse model , Wellcome Trust scientific conferences : 8th Molecular Biology of Hearing and Deafness Conference. 2011.

Leung Y.L., Gao B., Leung K.K.H., Melhado I.G., Wynn S.L., Au Y.K., Dung W.F., Lau J.Y.B., Mak A.C.Y., Chan D. and Cheah K.S.E., Sox9 governs differentiation stage-specific gene expression in growth plate chondrocytes via direct concomitant transactivation and repression., PLoS Genetics. 2011, 7(11): e1002356.

Researcher : Melhado IG

List of Research Outputs

Cheah K.S.E., Wang C., Tan Z., Niu B., Tsang K.Y., Melhado I.G., Zhang M.Q. and Chan D., Transcriptional control of chondrocyte differentiation and their adaptation to ER stress in vivo , Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012.

Cheah K.S.E., Wang C., Tan Z., Niu B., Tsang K.Y., Melhado I.G., Zhong M. and Chan D., Transcriptional control of chondrocyte differentiation and their adaptation to ER stress in vivo, Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012. 2012.

Leung Y.L., Gao B., Leung K.K.H., Melhado I.G., Wynn S.L., Au Y.K., Dung W.F., Lau J.Y.B., Mak A.C.Y., Chan D. and Cheah K.S.E., Sox9 governs differentiation stage-specific gene expression in growth plate chondrocytes via direct concomitant transactivation and repression., PLoS Genetics. 2011, 7(11): e1002356.

Researcher : Ng MH

Project Title:	Roles of Flightless-I associated proteins LRRFIP1 and LRRFIP2 in type-I interferon production
Investigator(s):	Ng MH, Jin D
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	10/2010
Completion Date:	03/2012

List of Research Outputs

Ng M.H., Ho T.H., Kok K.H., Siu K.L., Li J. and Jin D., MIP-T3 is a negative regulator of innate type I interferon response., J Immunol. 2011, 184: 6473-6482.

Ng M.H., Ho T.H., Siu K.L., Kok K.H. and Jin D., ROLES OF MITOCHONDRIAL TRAFFICKING PROTEINS IN TYPE-I INTERFERON PRODUCTION, 13th International Symposium of the Society of Chinese Bioscientists in America. 2011.

Ng M.H., Travel Award, Society Of Chinese Bioscientists In America. 2011.

Researcher : Ng VCW

List of Research Outputs

Chan W.C.W., Tsang K.Y., Ng V.C.W., Boot-Handford R., Cheah K.S.E. and Chan D., Activating ER-stress in differentiating osteocytes impairs maturation causing hyperostosis in mice , Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012.. 2012.

Ng V.C.W., Chan W.C.W., Gauci S., Fosang A. and Chan D., Role of type II collagen turnover in disc development and degeneration , World Forum for Spine Research 2012, Marina Congress Centre, Helsinki, Finland, 18-21 June, 2012.

Shen Y., Ng V.C.W., Shen W., Norito S., Cheung S.K.C., Agata K., Chan B.P., Lam Y.W. and Chan D., Extracellular matrix and stem cell niche in the regenerating planarian, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Shen Y., Ng V.C.W., Shen W., Norito S., Cheung S.K.C., Agata K., Chan B.P., Lam Y.W. and Chan D., Extracellular matrix and the stem cell niche in the regenerating planarian, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Yao Q., Ng V.C.W., Tan Z., Chan W.C.W., Tsang K.Y., Cheah K.S.E. and Chan D., Interplay between ER stree and hypoxia pathways in chondrocytes, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Researcher : Ngan WL

List of Research Outputs

Ngan W.L. and Yao K.M., EPS8 and FOXM1 - Do they mesh to promote carcinogenesis?, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Researcher : Ni Y

Project Title:	Novel role of Kif5b in clathrin uncoating
Investigator(s):	Ni Y, Huang J
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	08/2010

Project Title:	The 8th Asia Pacific Symposium on Neural Regeneration (APSNR) in conjunction with The 5th Pan Pacific Symposium on Stem Cells and Cancer Research (PPSSC) The 1st Cross-Strait Biotechnology Forum New role of motor protein Kif5b in signal transduction of M3 muscarinic acetylcholine receptor
Investigator(s):	Ni Y
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2012
Completion Date:	04/2012

Researcher : Niu B

Project Title:	Whole genome identification of active core promoters, enhancers and insulators in mouse growth plate
Investigator(s):	Niu B, Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	01/2010

List of Research Outputs

Cheah K.S.E., Wang C., Tan Z., Niu B., Tsang K.Y., Melhado I.G., Zhang M.Q. and Chan D., Transcriptional control of chondrocyte differentiation and their adaptation to ER stress in vivo , Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012.

Cheah K.S.E., Wang C., Tan Z., Niu B., Tsang K.Y., Melhado I.G., Zhong M. and Chan D., Transcriptional control of chondrocyte differentiation and their adaptation to ER stress in vivo, Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012. 2012.

Researcher : Osorio Da Silva LA

Project Title:	Isthmin in early embryonic development and gastrulation
Investigator(s):	Osorio Da Silva LA, Zhou Z
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2010
Completion Date:	10/2011

Researcher : Qian C

Project Title:	Structural and Functional Analysis of Oncoprotein UHRF1
Investigator(s):	Qian C
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2010

Project Title:	Structural insights into non-CG DNA methylation recognition
Investigator(s):	Qian C
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2011
Completion Date:	05/2012

Project Title:	Structural and Mechanistic Analysis of Human SMARCAL1
Investigator(s):	Qian C, Tanner JA
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2011

Project Title:	Gordon Research Conference on Chromatin Structure & Function UHRF1 double tudor domain and the adjacent PHD finger act together to recognize K9me3-containing histone H3 tail
Investigator(s):	Qian C
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2012

Project Title:	Structural and Mechanistic Characterization of XPA/RPA complex in DNA recognition
Investigator(s):	Qian C
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

List of Research Outputs

Qian C., Structure of RPA32 with N-terminus of SMARCAL1 reveals a consensus structural motif shared by RPA32 interacting proteins, 4th Asia-Pacific NMR symposium, Beijing, Young Investigator Talk. 2011.

Xie S. and Qian C., Structure of RPA32 Bound to SMARCAL1 Redefines the Binding Interface between RPA32 and Its Interacting Proteins, 4th Asia-Pacific NMR Symposium. 2011.

Xie S., Jakoncic J. and Qian C., UHRF1 Double Tudor Domain and the Adjacent PHD Finger Act Together to Recognize K9me3-Containing Histone H3 Tail, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Xie S., Jakoncic J. and Qian C., UHRF1 double tudor domain and the adjacent PHD finger act together to recognize K9me3-containing histone H3 tail, 2012 Gordon Research Conference on Chromatin Structure & Function. 2012.

Xie S., Jakoncic J. and Qian C., UHRF1 double tudor domain and the adjacent PHD finger act together to recognize K9me3-containing histone H3 tail, Journal of Molecular Biology. Elsevier, 2012, 415: 318-328.

Researcher : Qin J

List of Research Outputs

Qin J., Li J., Wang P., Zhang M.Q. and Wang J.J., ChIP-Array: Gene Regulation Network Construction from ChIP-seq/chip and mRNA expression data, The Fifth IEEE International Conference on Systems Biology, Zhuhai, China, 2-4 September 2011.

Qin J., Li J. and Wang J.J., ProteoMir express: inferring microRNA activities from mRNA and protein expression data, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Wang Y., Wang P., Qin J., Wang X.W., Zhang M.Q. and Wang J.J., EpiRegNet: constructing epigenetic regulatory network from high throughput gene expression data for humans, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Wang Y., Wang P., Li J., Qin J., Wang X.W., Zhang M.Q. and Wang J.J., EpiRegNet: constructing epigenetic regulatory network from high throughput gene expression data for humans, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Wang Y., Wang P., Li J., Qin J., Wang X.W., Zhang M.Q. and Wang J.J., EpiRegNet: constructing epigenetic regulatory network from high throughput gene expression data for humans, Bioinformatics of Human and Animal Genomics, Cold Spring Harbor Asia, Suzhou, China, 14-18 November 2011.

Wang Y., Wang P., Li J., Qin J., Wang X.W., Zhang M.Q. and Wang J.J., EpiRegNet: constructing epigenetic regulatory network from high throughput gene expression data for humans, The Fifth IEEE International Conference on Systems Biology, Zhuhai, China, 2-4 September 2011.

Wang Y., Wang P., Li J., Qin J., Wang X.W., Zhang M.Q. and Wang J.J., EpiRegNet: constructing epigenetic regulatory networks from high throughput gene expression data for human., Epigenetics. 2011, 6(12): 1505-12.

Researcher : Qin J

List of Research Outputs

Qin J., Li J. and Wang J.J., ProteoMir express: inferring microRNA activities from mRNA and protein expression data, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Wang Y., Wang P., Li J., Qin J., Wang X.W., Zhang M.Q. and Wang J.J., EpiRegNet: constructing epigenetic regulatory network from high throughput gene expression data for humans, Bioinformatics of Human and Animal Genomics, Cold Spring Harbor Asia, Suzhou, China, 14-18 November 2011.

Wang Y., Wang P., Li J., Qin J., Wang X.W., Zhang M.Q. and Wang J.J., EpiRegNet: constructing epigenetic regulatory network from high throughput gene expression data for humans, The Fifth IEEE International Conference on Systems Biology, Zhuhai, China, 2-4 September 2011.

Researcher : Sham MH

Project Title:	International Congress on Differentation and Cell Biology Neural-specific Cis-acting and Trans-acting Regulation of the Mouse Hoxb-3 Gene During Embryogenesis
Investigator(s):	Sham MH
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2000

Project Title:	Sonic hedgehog signaling and cross talks with Hox genes in hindbrain neurogenesis
Investigator(s):	Sham MH
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2009
Completion Date:	09/2011

Project Title:	Outstanding Research Student Supervisor Award 2008-2009
Investigator(s):	Sham MH
Department:	Biochemistry
Source(s) of Funding:	Outstanding Research Student Supervisor Award
Start Date:	12/2009

Project Title:	Visiting Research Professors Scheme 2010-11
Investigator(s):	Sham MH
Department:	Biochemistry
Source(s) of Funding:	Visiting Research Professors Scheme
Start Date:	09/2010

Project Title:	Enteric neural crest cell migration in the developing gut: Molecular and cellular analyses of a Sox10 mouse mutant
Investigator(s):	Sham MH
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2010

Project Title:	The roles of Hoxb3 and Jag1 in mediating branchial arch defects in Six1-Eya1 associated Branchio-Oto-Renal syndrome.
Investigator(s):	Sham MH
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2012

List of Research Outputs

Chen J.L., Wang X., Wang C.F., Ng T.C., Hou Y.H., Sun X.Y., Chow G.W.H., Enomoto H., Sham M.H., Burns A.J. and Chan W.Y., Migratory behaviours of sacral neural crest cells in the hindgut of mouse embryos as shown by live cell imaging., The 3rd International Symposium on Development of the Enteric Nervous System Cells, Signals and Genes, Hong Kong, 25-28 March, 2012.

Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Best Poster Award: Sox10 is essential for neural crest invasion in cochleo-vastibular ganglion. , 2012 Inter-University Postgraduate Symposium on Life Science, HKUST, Hong Kong, 9 June 2012.. 2012.

Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Sox10 is Essential for Neural Crest Invasion in Cochlea-Vestibular Ganglion, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Chu K.H., Zhang M., Wong E.Y.M., Chan Y.S., Cheah K.S.E. and Sham M.H., Sox10 is essential for neural crest invasion in cochleo-vastibular ganglion, 2012 Inter-University Postgraduate Symposium on Life Science, HKUST, Hong Kong, 9 June 2012.

Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Sox10 is essential for neural crest invasion in cochleo-vastibular ganglion, The 3rd International Symposium on Development of the Enteric Nervous System Cells, Signals and Genes, Hong Kong, 25-28 March, 2012.

Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Sox10 mutation affects gliogenesis of the cochleo-vestibular ganglion in mouse inner ear development, Third International Sox Meeting: From Structure to Function, Grainau, Munich, Germany, 11-14 September 2011.

Hor H.H., Wang X., Hui C.C. and Sham M.H., Best Poster Award: Suppressor of fused (Su(fu)) plays domain specific function in orchestrating the maintenance and differentiation of hindbrain neural progenitor pools., 2012 Inter-University Postgraduate Symposium on Life Science, HKUST, Hong Kong, 9 June 2012. . 2012.

Hor H.H., Wang X., Hui C.C. and Sham M.H., Suppressor of fused (Su(fu)) Plays Domain Specific Function in Orchestrating The Maintenance and Differentiation of Hindbrain Neural Progenitor Pools, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Hor H.H., Wang X., Hui C.C. and Sham M.H., Suppressor of fused (Su(fu)) modulates hindbrain hedgehog signaling and neurogenesis, International Society of Developmental Neuroscience 2012: Neurodevelopment and Neurological Diseases, Mumbai, India, 11-14 January 2012.

Hor H.H., Wang X., Hui C.C. and Sham M.H., Suppressor of fused (Su(fu)) plays domain specific function in orchestrating the maintenance and differentiation of hindbrain neural progenitor pools, 2012 Inter-University Postgraduate Symposium on Life Science, HKUST, Hong Kong, 9 June 2012. . 2012.

Lei I.L., Sham M.H. and Wang Z., ATP-dependent chromatin remodeling complex SWI/SNF in cardiogenesis and cardiac progenitor cell development., Frontiers in biology. 2012, 7(3): 202-211.

Lei I.L., Gao X., Sham M.H. and Wang Z., SWI/SNF component BAF250a regulates cardiac progenitor cell differentiation by modulating chromatin accessibility during second heart field development., Journal of Biological Chemistry. 2012, Epub ahead of print.

Leung C., Chan S.C.L., Tsang S.L., Wu W. and Sham M.H., Cyb26b1 mediates differential regulation of RA signaling in neural progenitor populations along the anterior-posterior axis of the adult spinal cord, Days of Molecular Medicine 2011, Re-engineering Regenerative Medicine, Hong Kong, 10-12 November 2011.

Leung C., Chan S.C.L., Tsang S.L., Wu W. and Sham M.H., Cyp26b mediates differential neurogenicity in axial-specific populations of adult spinal cord progenitor cells., Stem Cells and Development. 2012, Epub ahead of print.

Liu Y., Chu K.H., Hui C.C. and Sham M.H., Best Poster Award: The roles of Irx3 and Irx5 genes in mammalian inner ear development., 2012 Inter-University Postgraduate Symposium on Life Science, HKUST, Hong Kong, 9 June 2012. . 2012.

Liu Y., Hui C.C. and Sham M.H., The Irx3 and Irx5 genes in inner ear development, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Liu Y., Chu K.H., Hui C.C. and Sham M.H., The Roles of Irx3 and Irx5 Genes in Mammalian Inner Ear Development, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Liu Y., Chu K.H., Hui C.C. and Sham M.H., The roles of Irx3 and Irx5 genes inmammalian inner ear development, 2012 Inter-University Postgraduate Symposium on Life Science, HKUST, Hong Kong, 9 June 2012. . 2012.

Lu S., Lu L.Y., Yuan Q.J., Sham M.H., Guan X. and Huang J., Cerebellar defects in Pdss2 conditional knockout mice during embryonic development and in adulthood, Neurobiology of Disease. 2011, 45: 219-233.

Ma L., Sham M.H., Zheng L. and Cheung L.K., Influence of low dose nicotine on bone healing, Journal of Trauma. 2011, 70(6): E117-21.

Ng T.T., Sham M.H., Cheah K.S.E. and Ng R.K., Regeneration of nucleus pulposus cells for degenerative disc disorder, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Ngan E.S.W., Garcia-Barcelo M.M., Yip B.H.K., Poon P.C., Lau C.S.T., Kwok K.M., Sat E.W.Y., Sham M.H., Wong K.K.Y., Wainwright B.J., Cherny S.S., Hui C.C., Sham P.C., Lui V.C.H. and Tam P.K.H., Hedgehog/Notch-induced premature gliogenesis represents a new disease mechanism for Hirschsprung’s disease in mice and humans, Journal of Clinical Investigation. 2011, 121(9): 3467-3478.

Sham M.H., Member of the Academic Editorial Board, PLoS ONE. 2011.

Sham M.H., Review Editor, Frontiers in Autonomic Neuroscience. Frontiers Editorial Office, 2012.

Sham M.H., Sox10^NGFPmutation affects migration of enteric neural cress cells in mouse embryonic gut, The 3rd International Symposium on Development of the Enteric Nervous System Cells, Signals and Genes, Hong Kong, 25-28 March, 2012 (Invited Speaker). 2012.

Sham M.H., Special Issue: Development of the Enteric Nervous System, Developmental Biology. 2012.

Wang Y., Lu L., Wu M.H., Sham M.H., Chan D., Cheah K.S.E. and Cheung K.M.C., Induction of osteo-chondroprogenitors formation during transcription factor-mediated reprogramming processes, 10th Annual Meeting of International Society for Stem Cell Research, Yokohama, Japan. Jun 13-16 2012.. 2012.

Zhang M., Leung C., Sit H.M., Chu K.H., Lui V.C.H., Tam P.K.H. and Sham M.H., Sox10 ^NGFP mutation affects migration of enteric neural cress cells in mouse embryonic gut, The 3rd International Symposium on Development of the Enteric Nervous System Cells, Signals and Genes, Hong Kong, 25-28 March, 2012.

Researcher : Sham PC

Project Title:	Replication study of susceptibility genes for colorectal cancer
Investigator(s):	Sham PC, Ho JWC, Cheng KK
Department:	Medical Faculty
Source(s) of Funding:	Small Project Funding
Start Date:	10/2007

Project Title:	Visiting Research Professors Scheme 2009-10
Investigator(s):	Sham PC
Department:	Medical Faculty
Source(s) of Funding:	Visiting Research Professors Scheme
Start Date:	09/2009

Project Title:	To determine the functional variants of candidate genes identified by Genome-wide Association Study of Osteoporosis
Investigator(s):	Sham PC, Gao RY, Xiao S, Kung AWC
Department:	Medical Faculty
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2010

Project Title:	Genetic studies of endophenotypes for psychosis
Investigator(s):	Sham PC
Department:	Medical Faculty
Source(s) of Funding:	Small Project Funding
Start Date:	10/2010

Project Title:	Method and Software for Personal Risk Profiling of Complex Diseases
Investigator(s):	Sham PC, Cherny SS, Garcia-Barcelo MM, Kung AWC, Li M, Yang W
Department:	Psychiatry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2012

List of Research Outputs

Li M., Gui H., Kwan S.H., Bao S. and Sham P.C., A Comprehensive Framework For Prioritizing Variants In Exome Sequencing Studies Of Mendelian Diseases, Nucleic Acids Research. 2012.

Li M., Pang S.Y.Y., Song Y., Kung M.H.W., Ho S.L. and Sham P.C., Whole exome sequencing identifies a novel mutation in the transglutaminase 6 gene for spinocerebellar ataxia in a Chinese family., Clinical Genetics. 2012, 3. doi: 10.1111/j.1399-0004.2012.01895.x.

Researcher : Shea GKH

List of Research Outputs

Cai S., Shea G.K.H., Tsui Y.P., Chan Y.S. and Shum D.K.Y., Derivation of clinically applicable schwann cells from bone marrow stromal cells for neural repair and regeneration., CNS Neurol Disord Drug Targets. 2011, 11: 500-508.

Leung H.Y., Tsui Y.P., Shea G.K.H., Tai W.Y.E., Chan Y.S. and Shum D.K.Y., Involvement of Neuregulin 1 Type III in the Ex Vivo Generation of Fate Committed Schwann Cells from Bone Marrow Stromal Cells, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Leung H.Y., Tsui Y.P., Shea G.K.H., Tai W.Y.E., Chan Y.S. and Shum D.K.Y., Role of neuregulin 1 type III in the generation of fate committed Schwann cells from bone marrow stromal cells, Abstracts of 7^th Int’l Symp. on Healthy Aging: Live Well, Age Well : 66. 2012.

Leung H.Y., Tsui Y.P., Shea G.K.H., Tai W.Y.E., Chan Y.S. and Shum D.K.Y., Signal involved in the switch to fate commitment of bone marrow-derived Schwann cells, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 74. 2012.

Shum D.K.Y., Tai W.Y.E., Shea G.K.H., Leung H.Y. and Chan Y.S., Roles of notch and ErbB signaling in the fate commitment of bone marrow-derived Schwann cells, Proc. 8th IBRO World Congress of Neuroscience: B077 [Florence Italy July 14-18, 2011] . 2011.

Tai W.Y.E., Shea G.K.H., Leung H.Y., Chan Y.S. and Shum D.K.Y., Mechanism behind the fate commitment of bone marrow-derived schwann cells, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Tai W.Y.E., Shea G.K.H., Tsui Y.P., Leung H.Y., Chan Y.S. and Shum D.K.Y., Notch signaling mediates the switch to fate commitment of bone marrow-derived Schwann cells, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 74. 2012.

Tai W.Y.E., Shea G.K.H., Tsui Y.P., Leung H.Y., Tam K.W., Chan Y.S. and Shum D.K.Y., Signals Involved In The Switch To Fate Commitment Of Bone Marrow-derived Schwann Cells, Seventh International Symposium on Healthy Aging, P45. 2012.

Tai W.Y.E., Shea G.K.H., Tsui Y.P., Leung K.H., Tam K.W., Chan Y.S. and Shum D.K.Y., Signals involved in the switch to fate commitment of bone marrow-derived Schwann cells, Abstracts of 7^th Int’l Symp. on Healthy Aging: Live Well, Age Well : 70. 2012.

Researcher : Shen Y

List of Research Outputs

Shen Y., Ng V.C.W., Shen W., Norito S., Cheung S.K.C., Agata K., Chan B.P., Lam Y.W. and Chan D., Extracellular matrix and stem cell niche in the regenerating planarian, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Shen Y., Ng V.C.W., Shen W., Norito S., Cheung S.K.C., Agata K., Chan B.P., Lam Y.W. and Chan D., Extracellular matrix and the stem cell niche in the regenerating planarian, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Researcher : Shi L

List of Research Outputs

Shi L., Song E.W. and Huang J., Development of a trans-kingdom expression system in cancer therapy, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Yu B., Yang M., Shi L., Yao Y.D., Jiang Q.Q., Li X.F., Tang L.H., Zheng B., Yuen K.Y., Smith D.K., Song E.W. and Huang J., Explicit hypoxia targeting with tumor suppression by creating an "obligate" anaerobic Salmonella Typhimurium strain , Scientific Reports . 2012, 2: 436.

Researcher : Shum DKY

Project Title:	30th Annual Conference of Society for Neuroscience Effects of Chondroitin Sulfate Supplements on Regeneration of Bridged Sciatic Nerves
Investigator(s):	Shum DKY
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2000

Project Title:	31st Annual Meeting of Society for Neuroscience Expression of Chondroitin 6-sulfotransferase mRNA and the Sulfation Product in Post-crush Sciatic Nerves of Adult Rats
Investigator(s):	Shum DKY
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2001

Project Title:	Expression of heparanase in the injured spinal cord
Investigator(s):	Shum DKY
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Project Title:	33rd Annual Conference of the Society for Neuroscience Spatiotemporal Expression of Chondroitin 6-Sulfotransferase (C6ST) In Regeneration of Crush-injured Sciatic Nerves of Adult Rats C6ST Expression in Sciatic Nerve Explant Culture of Adult Rats
Investigator(s):	Shum DKY
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2003

Project Title:	Expression of chondroitin sulfotransferases in the injured spinal cord
Investigator(s):	Shum DKY
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Project Title:	Proteoglycans in Signaling Heparan Sulfate/Syndecan-1 Modulates the Balance between Proteinase and Anti-Proteinase in Bronchiectasis
Investigator(s):	Shum DKY
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2005

Project Title:	Heparan sulfate oligosaccharide preparations - novel therapeutics in chronic inflammation
Investigator(s):	Shum DKY
Department:	Biochemistry
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	10/2007

Project Title:	Use of a rat model of chronic obstructive pulmonary disease to address neutrophil elastase/anti-elastase imbalance in the airways
Investigator(s):	Shum DKY, Ip MSM, Chan CH
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	12/2008

Project Title:	Role of heparanase in synaptic plasticity at the vestibular nucleus
Investigator(s):	Shum DKY, Chan YS
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2009

Project Title:	From bone marrow stromal cells to Schwann cells an in vitro route to specification
Investigator(s):	Shum DKY, Chan YS
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2010

Project Title:	A Novel Nerve Conduit that Combines Schwann Cell-seeded Chitosan Nanofibres with Chondroitinase ABC-loaded Chitosan Microbeads for Post-traumatic Nerve Regeneration
Investigator(s):	Shum DKY, Chan YS, Tam KW
Department:	Biochemistry
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	07/2011

Project Title:	A Novel Nerve Conduit that Combines Schwann Cell-seeded Chitosan Nanofibres with Chondroitinase ABC-loaded Chitosan Microbeads for Post-traumatic Nerve Regeneration
Investigator(s):	Shum DKY
Department:	Biochemistry
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	07/2011

Project Title:	8th World Congress of Neuroscience Roles of Notch and ErbB signaling in the fate commitment of bone marrow-derived Schwann cells
Investigator(s):	Shum DKY
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2011
Completion Date:	07/2011

Project Title:	Proheparanase and AMPA receptor trafficking in synaptic plasticity
Investigator(s):	Shum DKY, Chan YS
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2011

Project Title:	From bone marrow stromal cells to Schwann cells – in vitro route to specification and utility in re-myelination therapy
Investigator(s):	Shum DKY, Chan YS
Department:	Biochemistry
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2012

List of Research Outputs

Cai S., Tsui A.Y., Chan Y.S. and Shum D.K.Y., Characterization of human bone marrow stromal cells following differentiation into Schwann cells, Abstracts of 7^th Int’l Symp. on Healthy Aging: Live Well, Age Well : 69. 2012.

Cai S., Shea G.K.H., Tsui Y.P., Chan Y.S. and Shum D.K.Y., Derivation of clinically applicable schwann cells from bone marrow stromal cells for neural repair and regeneration., CNS Neurol Disord Drug Targets. 2011, 11: 500-508.

Cai S., Tsui A.Y., Chan Y.S. and Shum D.K.Y., Stable derivation of Schwann cells from human bone marrow stromal cells, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 57. 2012.

Chan Y.S., Lai S.K., Ma C.W., Wong T.P. and Shum D.K.Y., Acquisition of glutamate receptors in central vestibular synapses is crucial for developmental recognition of spatial orientation, 8th IBRO World Congress of Neuroscience, Florence, Italy. July 14-18. S16.3. 2011.

Chan Y.S., Ma C.W., Ng K.P. and Shum D.K.Y., Plasticity of neural correlates for spatial navigation, Abstracts of 2011 Neuroscience Symposium p. 16. [Kuala Lumpur, Malaysia. December 12-13, 2011]. 2011.

Chan Y.S., Lai S.K., Ma C.W., Hu H., Wong T.P. and Shum D.K.Y., The engagement of glutamate and GABA receptors in mediating spatial recognition behavior, Proc. 7^th Congress of the Federation of Asian and Oceanian Physiological Societies p.35 [Taipei, Taiwan September 12-15, 2011]. 2011.

Kwok J.C., Yuen Y.L., Lau W.K., Zhang F.X., Fawcett J.W., Chan Y.S. and Shum D.K.Y., Chondroitin sulfates in the developing rat hindbrain confine commissural projections of vestibular nuclear neurons, Neural Development 7: art. 6. 2012.

Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Activity assays of Chondroitinase ABCI immobilized on chitosan beads, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Immobilization Of Chondroitinase ABCI On Chitosan Beads To Improve Axonal Regrowth In Cspg-enriched Astrocyte Culture, Hong Kong-Taiwan Physiology Symposium 2012 and Joint Scientific Meeting of Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong, P62. 2012.

Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Immobilization of chondroitinase ABCI on chitosan beads to improve axonal regrowth in CSPG-enriched astrocyte culture, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 75. 2012.

Lam Y.L., Cham W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Involvement of proheparanase and peri-synaptic heparan sulfate proteoglycan in synaptic plasticity to regulate AMPA-Type glutamate receptor trafficking, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Lam Y.L., Cham W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Modulation of synaptic plasticity by the partnership of proheparanase with peri-synaptic heparan sulfate proteoglycan and AMPA-type glutamate receptor, Abstracts of 7th Int’l Symp. on Healthy Aging: 73. 2012.

Lam Y.L., Cham W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Proheparanase-mediated AMPA-type glutamate receptor regulation in synaptic plasticity, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Lam Y.L., Cham W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Regulation of AMPA-type glutamate receptor trafficking by proheparanase in synaptic plasticity, Society Neuroscience Abstract (USA), 870.09/D41. 2011.

Lam Y.L., Cham W.C., Ma C.W., Chan Y.S. and Shum D.K.Y., Regulatory role of proheparanase with peri-synaptic heparan sulfate proteoglycan and AMPA-type glutamate receptor in synaptic plasticity, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 73. 2012.

Leung H.Y., Tsui Y.P., Shea G.K.H., Tai W.Y.E., Chan Y.S. and Shum D.K.Y., Involvement of Neuregulin 1 Type III in the Ex Vivo Generation of Fate Committed Schwann Cells from Bone Marrow Stromal Cells, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Leung H.Y., Tsui Y.P., Shea G.K.H., Tai W.Y.E., Chan Y.S. and Shum D.K.Y., Role of neuregulin 1 type III in the generation of fate committed Schwann cells from bone marrow stromal cells, Abstracts of 7^th Int’l Symp. on Healthy Aging: Live Well, Age Well : 66. 2012.

Leung H.Y., Tsui Y.P., Shea G.K.H., Tai W.Y.E., Chan Y.S. and Shum D.K.Y., Signal involved in the switch to fate commitment of bone marrow-derived Schwann cells, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 74. 2012.

Li C., Han L., Ma C.W., Lai S.K., Lai C.H., Shum D.K.Y. and Chan Y.S., Maturation profile of inferior olivary neurons expressing ionotropic glutamate receptors: Role in coding linear accelerations, Brain Structure and Function [Epub ahead of print]. 2012.

Ma C.W., Lai C.H., Chan Y.S. and Shum D.K.Y., Involvement of perineuronal nets in developmental plasticity of the central vestibular system, Abstracts of 7th Int’l Symp. on Healthy Aging: 60. 2012.

Ma C.W., Lai C.H., Chan Y.S. and Shum D.K.Y., Roles of perineuronal matrix in developmental plasticity of the central vestibular system, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 73. 2012.

Ma C.W., Cham W.C., Lai C.H., Chan Y.S. and Shum D.K.Y., The regulatory role of proheparanase in synaptic plasticity at the hippocampus, 8th IBRO World Congress of Neuroscience, Florence, Italy. July 14-18, B199. 2011.

Ma C.W., Cham W.C., Lai C.H., Shum D.K.Y. and Chan Y.S., The role of proheparanase in synaptic plasticity at the hippocampus, 9th Biennial Conference of the Chinese Neuroscience Society and The 5th Member Congress, Zhengzhou, China. Jul 29 - Aug 1, P-110. 2011.

Shi W., Botelho F.P., Shum D.K.Y. and Chan Y.S., Role of endocannabinoid and GABA_A receptor in modulating synaptic plasticity in the vestibular nucleus of postnatal rats, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 68. 2012.

Shum D.K.Y., Tai W.Y.E., Shea G.K.H., Leung H.Y. and Chan Y.S., Roles of notch and ErbB signaling in the fate commitment of bone marrow-derived Schwann cells, Proc. 8th IBRO World Congress of Neuroscience: B077 [Florence Italy July 14-18, 2011] . 2011.

Tai W.Y.E., Shea G.K.H., Leung H.Y., Chan Y.S. and Shum D.K.Y., Mechanism behind the fate commitment of bone marrow-derived schwann cells, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Tai W.Y.E., Shea G.K.H., Tsui Y.P., Leung H.Y., Chan Y.S. and Shum D.K.Y., Notch signaling mediates the switch to fate commitment of bone marrow-derived Schwann cells, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 74. 2012.

Tai W.Y.E., Shea G.K.H., Tsui Y.P., Leung H.Y., Tam K.W., Chan Y.S. and Shum D.K.Y., Signals Involved In The Switch To Fate Commitment Of Bone Marrow-derived Schwann Cells, Seventh International Symposium on Healthy Aging, P45. 2012.

Tai W.Y.E., Shea G.K.H., Tsui Y.P., Leung K.H., Tam K.W., Chan Y.S. and Shum D.K.Y., Signals involved in the switch to fate commitment of bone marrow-derived Schwann cells, Abstracts of 7^th Int’l Symp. on Healthy Aging: Live Well, Age Well : 70. 2012.

Tam K.W., Chan Y.S. and Shum D.K.Y., Combinatorial use of chondroitin sulphate lyase subtypes in the treatment of nerve injury , Neuroscience 2011, 64.09/GG26 . 2011.

Tam K.W., Chan Y.S. and Shum D.K.Y., Factors Underlying Improved Efficacy Of Chondroitin Sulphate Lyases In Overcoming Chondroitin Sulphate Barriers For Nerve Repair And Regeneration, Seventh International Symposium on Healthy Aging, P5. 2012.

Tam K.W., Chan Y.S. and Shum D.K.Y., The Mechanisms of Chondroitin Sulphate Lyases Treatment in Promotion of Axonal Growth, Hong Kong-Taiwan Physiology Symposium 2012 and Joint Scientific Meeting of Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong, P57. 2012.

Tsui Y.P., Li R.S., Lo A.C.Y., Chan Y.S. and Shum D.K.Y., Derivation of oligodendrocyte precursors from bone marrow stromal cells for myelination therapy, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong: 72. 2012.

Tsui Y.P., Li S.Y., Lo A.C.Y., Chan Y.S. and Shum D.K.Y., Derivation of oligodendrocyte precursors from bone marrow stromal cells for remyelination therapy, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Tsui Y.P., Li S.Y., Lo A.C.Y., Chan Y.S. and Shum D.K.Y., Generation of oligodendrocyte precursors from bone marrow stromal cells for remyelination therapy, Abstracts of 7^th Int’l Symp. on Healthy Aging: Live Well, Age Well : 65.. 2012.

Tung W.T., Chan Y.S. and Shum D.K.Y., ALIGNED CHITOSAN NANO-FIBERS FOR NERVE REGENERATION, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Tung W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Preparation of Chitosan Fibers for Nerve Regeneration, Hong Kong-Taiwan Physiology Symposium 2012 and Joint Scientific Meeting of Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong, P63. 2012.

Tung W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Preparation of chitosan fibers for nerve regeneration, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 75. 2012.

Wong K.L., Ngan A.H.W., Shum D.K.Y. and Lu W.W., Nanomechanical study of vimentin intermediate filament , 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Wong Y.K., Han S.J., Chan C.H., Shum D.K.Y., Chan G.C.F. and Chan B.P., Characterization of human mesenchymal stem cells selected by collagen barrier., Tissue Engineering and Regenerative Medicine International Society Asia-Pacific Chapter Meeting (TERMIS-AP) 3-5 Aug 2011. Waterfront Conference Centre, Singapore.. 2011, 182.

Wu L.K., Chan C.H., Ip M.S.M. and Shum D.K.Y., Heparanase Activity Facilitates Syndecan-1 Shedding in Airway Inflammation, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Researcher : Shum KT

List of Research Outputs

Ao K.L., Shum K.T. and Tanner J.A., Dissecting the mechanism of binding between polyphosphate and polyphosphate kinase 2, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Tanner J.A., Shum K.T. and Chan S.L.C., High-affinity nucleic acid aptamers against sclerostin protein, PCT Patent. 2011, WO2011/147193.

Tucker W.O., Shum K.T. and Tanner J.A., G-quadruplex DNA Aptamers and their Ligands: Structure, Function and Application, Current Pharmaceutical Design. 2012, 18: 2014-2026.

Researcher : Shum KT

List of Research Outputs

Tanner J.A., Shum K.T. and Chan S.L.C., High-affinity nucleic acid aptamers against sclerostin protein, PCT Patent. 2011, WO2011/147193.

Tucker W.O., Shum K.T. and Tanner J.A., G-quadruplex DNA Aptamers and their Ligands: Structure, Function and Application, Current Pharmaceutical Design. 2012, 18: 2014-2026.

Researcher : Sit HM

List of Research Outputs

Zhang M., Leung C., Sit H.M., Chu K.H., Lui V.C.H., Tam P.K.H. and Sham M.H., Sox10 ^NGFP mutation affects migration of enteric neural cress cells in mouse embryonic gut, The 3rd International Symposium on Development of the Enteric Nervous System Cells, Signals and Genes, Hong Kong, 25-28 March, 2012.

Researcher : Siu KL

List of Research Outputs

Lei T., Siu K.L., Kok K.H., Chan K.H., Chan E.Y.T., Hung I.F.N., To K.K.W., Li P.C.K., Zhou J., Zheng B., Yuen K.Y., Wang M. and Jin D., Anti-ganglioside antibodies were not detected in human subjects infected with or vaccinated against 2009 pandemic influenza A (H1N1) virus., Vaccine. 2012, 30: 2605-2610.

Ng M.H., Ho T.H., Kok K.H., Siu K.L., Li J. and Jin D., MIP-T3 is a negative regulator of innate type I interferon response., J Immunol. 2011, 184: 6473-6482.

Ng M.H., Ho T.H., Siu K.L., Kok K.H. and Jin D., ROLES OF MITOCHONDRIAL TRAFFICKING PROTEINS IN TYPE-I INTERFERON PRODUCTION, 13th International Symposium of the Society of Chinese Bioscientists in America. 2011.

Researcher : Siu YT

List of Research Outputs

Tang V.H.M., Siu Y.T., Chan C.P., Kok K.H. and Jin D., STK11 inhibits transcriptional activation of HTLV-I LTR by Tax transactivator, The 70th Annual Meeting of the Japanese Cancer Association (JCA). 2011.

Researcher : Smith DK

Project Title:	Patterns in proteins with unusual flexibility profiles
Investigator(s):	Smith DK
Department:	Biochemistry
Source(s) of Funding:	Seed Funding for New Staff
Start Date:	08/2002

Researcher : Song Y

Project Title:	A Randomized Controlled Trial of the Therapeutic Effects of Tai Chi and Mahjong on Older Persons With Cognitive Impairment
Investigator(s):	Song Y
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2008

Project Title:	Detecting genes and functional analysis of a novel gene (Cer1) significantly associated with bone mineral density (BMD) in mice.
Investigator(s):	Song Y, Chan D, Sham PC, Tanner JA
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2009
Completion Date:	12/2011

Project Title:	Identification of small molecule inhibitors of Pax6 in neuronal apoptosis of Alzheimer’s Disease
Investigator(s):	Song Y, Kao RYT, Chu LW, Zhang Y
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	12/2010
Completion Date:	11/2011

Project Title:	Identification of a genetic variant for heart defects (CHD) in mice, which is a susceptibility factor for CHD in human
Investigator(s):	Song Y, Cheah KSE, Sham PC
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2011
Completion Date:	12/2011

Project Title:	In silico identification of genetic variations that affect resistance to influenza A virus infection
Investigator(s):	Song Y, To KKW, Zhou J
Department:	Biochemistry
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	12/2011

Project Title:	Uncovering the mechanism of oncoviruses in causing cancers using pluripotency signatures
Investigator(s):	Song Y, Zhu H
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

List of Research Outputs

Chen L., Kao P.Y.P., Fan Y., Ho D.T.Y., Yik P.Y., Ha C.T., Chu L.W. and Song Y., Association between CLU Polymorphisms and clinical phenotypes in Alzheimer’s Disease, Alzheimer's Association International Conference (AAIC) . 2011.

Chen L., Kao P.Y.P., Fan Y., Ho T.Y., Yik P.Y., Ha C.T.J., Chu L.W. and Song Y., Polymorphisms of CR1, CLU and PICALM confer susceptibility of Alzheimer's disease in a southern Chinese population , Neurobiol Aging. 2012, 33(1):210.e: 1-7.

Chen L., Kao P.Y.P., Fan Y., Chu L.W. and Song Y., The genetic polymorphisms in sex steroid metabolic pathway and risk for sporadic Alzheimer's disease, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Fan Y., Cheung K.M.C., Chan D., Cheung W.Y., Cheah K.S.E., Sham P.C., Luk K.D.K. and Song Y., Genome-Wide Association Study of Adolescent Idiopathic Scoliosis in Southern Chinese, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Fan Y. and Song Y., IPGWAS: An integrated pipeline for rational quality control and association analysis of genome-wide genetic studies, Biochem Biophys Res Commun. 2012, 422(3): 363-368.

Fan Y., Song Y., Chan D., Takahashi Y., Ikegawa S., Matsumoto M., Kou I., Cheah K.S.E., Sham P.C., Cheung K.M.C. and Luk K.D.K., SNP rs11190870 near LBX1 is associated with adolescent idiopathic scoliosis in southern Chinese., J Hum Genet . 2011, 57(4): 244-6.

Jia Y., Yu S.J. and Song Y., Computational construction of the downstream network of Pax6 in AD neuronal death model, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Kao P.Y.P., Chan D., Samartzis D., Sham P.C. and Song Y., Genetics of lumbar disk degeneration: technology, study designs, and risk factors, Orthop Clin North Am. 2011, 42(4): 479-86.

Kelempisioti A., Eskola P.J., Okuloff A., Karjalainen U., Takatalo J., Daavittila I., Niinimaki J., Sequeiros R.B., Tervonen O., Solovieva S., Kao P.Y.P., Song Y., Cheung K.M.C., Chan D., Ala-Kokko L., Jarvelin M.R., Karppinen J. and Mannikko M., Genetic susceptibility of intervertebral disc degeneration among young Finnish adults, BMC Medical Genetics. 2011, 12: 153.

Lam H.C., Cherny S.S., Wong E.H.M., Sham P.C., Jin D. and Song Y., Functional characterisation reveals PTPN21 as a positive mediator of NRG3, a potential risk factor in Schizophrenia , 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Li M., Pang S.Y.Y., Song Y., Kung M.H.W., Ho S.L. and Sham P.C., Whole exome sequencing identifies a novel mutation in the transglutaminase 6 gene for spinocerebellar ataxia in a Chinese family., Clinical Genetics. 2012, 3. doi: 10.1111/j.1399-0004.2012.01895.x.

Tang S.M., Cheng G., So M.T., Yip B.H.K., Miao X., Wong E.H.M., Ngan E.S.W., Lui V.C.H., Song Y., Chan D., Cheung K.M.C., Yuan Z.W., Lei L., Chung H.Y., Liu X., Wong K.K.Y., Marshall C.R., Scherer S., Cherny S.S., Sham P.C., Tam P.K.H. and Garcia-Barcelo M.M., Genome-wide copy number analysis uncovers a new HSCR gene: NRG3, PLoS Genetics. 2012, 8(5): e1002687.

Zhou L., Chan K.H., Chu L.W., Kwan S.C., Song Y., Chen L., Ho W.L., Cheng O.Y., Ho W.M. and Lam K.S.L., Plasma amyloid-β oligomers level is a biomarker for Alzheimer’s disease diagnosis, Biochemical and Biophysical Research Communications. 2012, 423(4): 697-702.

Researcher : Sze KL

List of Research Outputs

Chan W.C.W., Sze K.L., Samartzis D., Leung Y.L. and Chan D., Structure and biology of the intervertebral disk in health and disease, Orthop Clin North Am. 2011, 4: 447-64.

Researcher : Szeto YY

Project Title:	Transcriptional regulation of Aqp3 by Sox9 and Sox9Y440X in the mouse inner ear
Investigator(s):	Szeto YY, Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	05/2012

List of Research Outputs

Cheah K.S.E., Szeto Y.Y., Au Y.K., Wynn S., Mak A.C.Y., Chan Y.S., Lovell-Badge R., Chan W.Y. and Fritzsch B., Defects in cochlear structure and function in the Sox9Y440X campomelic dysplasia mouse model , Wellcome Trust scientific conferences : 8th Molecular Biology of Hearing and Deafness Conference. 2011.

Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Best Poster Award: Sox10 is essential for neural crest invasion in cochleo-vastibular ganglion. , 2012 Inter-University Postgraduate Symposium on Life Science, HKUST, Hong Kong, 9 June 2012.. 2012.

Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Sox10 is Essential for Neural Crest Invasion in Cochlea-Vestibular Ganglion, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Sox10 is essential for neural crest invasion in cochleo-vastibular ganglion, The 3rd International Symposium on Development of the Enteric Nervous System Cells, Signals and Genes, Hong Kong, 25-28 March, 2012.

Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Sox10 mutation affects gliogenesis of the cochleo-vestibular ganglion in mouse inner ear development, Third International Sox Meeting: From Structure to Function, Grainau, Munich, Germany, 11-14 September 2011.

Researcher : Tai CP

Project Title:	Conservation of chordate SOXE protein function in chondrogenesis
Investigator(s):	Tai CP, Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	02/2012

List of Research Outputs

Chen Y., Tai C.P., Kai K.L.A., Xu A., Lam K.S.L., Tam S., Chung S.S.M. and Chung S.K., Exchange Protein directly Activated by cAMP 1 is Involved in b3-adreneric Induction of Brown Adipose Tissue in White Adipose Tissue, The 72nd scientific section - American Diabetes Association. 2012.

Chen Y., Tai C.P., Kai K.L.A., Xu A., Lam K.S.L., Tam S., Chung S.S.M. and Chung S.K., Exchange Protein directly Activated by cAMP 1 is Involved in b3-adrenergic Induction of Brown Adipose Tissue in White Adipose Tissue, The 7th International Symposium on Healthy Aging organised by the Research Centre of Heart, Brain, Hormone and Healthy Aging. 2012.

Researcher : Tam JWO

Project Title:	14th Annual San Diego Conference: Nucleic Acid Technologies in Disease Detection Direct Flow-Through Hybridisation Device: An Effective and Lost Cost Apparatus for Rapid DNA Analysis
Investigator(s):	Tam JWO
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/1999

Researcher : Tam KW

List of Research Outputs

Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Activity assays of Chondroitinase ABCI immobilized on chitosan beads, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Kwok L.F., Tam K.W., Chan Y.S. and Shum D.K.Y., Immobilization Of Chondroitinase ABCI On Chitosan Beads To Improve Axonal Regrowth In Cspg-enriched Astrocyte Culture, Hong Kong-Taiwan Physiology Symposium 2012 and Joint Scientific Meeting of Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong, P62. 2012.

Tai W.Y.E., Shea G.K.H., Tsui Y.P., Leung H.Y., Tam K.W., Chan Y.S. and Shum D.K.Y., Signals Involved In The Switch To Fate Commitment Of Bone Marrow-derived Schwann Cells, Seventh International Symposium on Healthy Aging, P45. 2012.

Tam K.W., Chan Y.S. and Shum D.K.Y., Combinatorial use of chondroitin sulphate lyase subtypes in the treatment of nerve injury , Neuroscience 2011, 64.09/GG26 . 2011.

Tam K.W., Chan Y.S. and Shum D.K.Y., Factors Underlying Improved Efficacy Of Chondroitin Sulphate Lyases In Overcoming Chondroitin Sulphate Barriers For Nerve Repair And Regeneration, Seventh International Symposium on Healthy Aging, P5. 2012.

Tam K.W., Chan Y.S. and Shum D.K.Y., The Mechanisms of Chondroitin Sulphate Lyases Treatment in Promotion of Axonal Growth, Hong Kong-Taiwan Physiology Symposium 2012 and Joint Scientific Meeting of Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong, P57. 2012.

Tung W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Preparation of Chitosan Fibers for Nerve Regeneration, Hong Kong-Taiwan Physiology Symposium 2012 and Joint Scientific Meeting of Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong, P63. 2012.

Researcher : Tam PKH

Project Title:	Establishing a "train-the-trainers" programme for paediatric surgery in China
Investigator(s):	Tam PKH, Lin C
Department:	Surgery
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	10/1998

Project Title:	Expanding the "Train-the-Trainers" programme for paediatric surgery in China
Investigator(s):	Tam PKH, Lin C
Department:	Surgery
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	10/2000

Project Title:	Improving the survival and quality of life of children with cancers in China
Investigator(s):	Tam PKH, Wong IHN, Chan GCF, Ren Y, Lin C
Department:	Surgery
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	10/2003

Project Title:	The study of co-stimulatory function of sonic hedgehog in CD⁴⁺ lymphocytes
Investigator(s):	Tam PKH, Chan VSF
Department:	Surgery
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Project Title:	Further expansion of the "Train-the-Trainers" programme for paediatric surgery in China
Investigator(s):	Tam PKH, Chan KL, Wong KKY
Department:	Surgery
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	05/2005

Project Title:	Offering Iaparoscopic surgical workshops in China
Investigator(s):	Tam PKH, Wong KKY, Yip PKF
Department:	Surgery
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	01/2007

Project Title:	Offering surgical care to poor children with major congenital anomalies in rural China
Investigator(s):	Tam PKH, Wong KKY, Yip PKF
Department:	Surgery
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	04/2008

Project Title:	Genome-wide association study for the identification of genes underlying anorectal malformations
Investigator(s):	Tam PKH, Cherny SS, Garcia-Barcelo MM, Sham PC
Department:	Surgery
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2008
Completion Date:	08/2011

Project Title:	Establishing a quaternary peadiatric gastrointestinal centre for Hong Kong
Investigator(s):	Tam PKH, Wong KKY, Wong RMS
Department:	Surgery
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	12/2008

Project Title:	Improving the surgical care of sick children in Hong Kong by providing cutting edge minimally invasive and robotic surgery
Investigator(s):	Tam PKH
Department:	V-C's Office
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	03/2009

Project Title:	NRG1 intron 1 SNPs in Hirschsprung’s disease
Investigator(s):	Tam PKH, Garcia-Barcelo MM
Department:	Surgery
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2010
Completion Date:	02/2012

Project Title:	Establishing S.K. Yee Medical Foundation clinical fellowships
Investigator(s):	Tam PKH, Wong KKY
Department:	Surgery
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	08/2010

Project Title:	Deep Re-Sequencing of Hirschsprung's Disease Candidate Genes
Investigator(s):	Tam PKH, Cherny SS, Garcia-Barcelo MM, Lok S, Sham PC
Department:	Surgery
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2010

Project Title:	Validation of NRG3 copy number variations in the genome of Hirschsprung's patients
Investigator(s):	Tam PKH, Garcia-Barcelo MM
Department:	Surgery
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2011

Project Title:	BAPS 2011 International Congress Identification of ADD3 as a susceptible gene for biliary atresia: evidence from genetic fine mapping
Investigator(s):	Tam PKH
Department:	Surgery
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2011
Completion Date:	07/2011

Project Title:	Advancing laparoscopic skills in China - an extension of the current laparoscopic workshop scheme
Investigator(s):	Tam PKH, Wong KKY
Department:	Surgery
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	03/2012

Project Title:	Study of de novo copy number variations (CNV) in Hirschsprung disease
Investigator(s):	Tam PKH, Garcia-Barcelo MM
Department:	Surgery
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

List of Research Outputs

Leung J.L., Chung H.Y., Lan L.C.L., Wong K.K.Y. and Tam P.K.H., Management of tracheobronchial obstruction in infants using metallic stents: long-term outcome, The 45th Annual Meeting of Pacific Association of Pediatric Surgeons, Shanghai, China, 3 - 7 June 2012.

Researcher : Tam PPL

List of Research Outputs

Wang X., Cheung M.C.H., Tam P.P.L., Briscoe J. and Chan D., Molecular consequences of Indian Hedgehog mutations causing brachydactylies in chick neural tube, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Researcher : Tan TY

List of Research Outputs

Tan T.Y., Pierre Robin Sequence and SOX9 in Craniofacial Development, Victorian Clinical Genetics Services Seminar - Melbourne, Australia, 18May 2012.. 2012.

Tan T.Y., Pierre Robin Sequence, SOX9 and the Relevance of 'Junk DNA', Royal Children's Hospital Neonatology meeting - Melbourne, Australia, 4May 2012.. 2012.

Researcher : Tan Z

List of Research Outputs

Cheah K.S.E., Wang C., Tan Z., Niu B., Tsang K.Y., Melhado I.G., Zhang M.Q. and Chan D., Transcriptional control of chondrocyte differentiation and their adaptation to ER stress in vivo , Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012.

Cheah K.S.E., Wang C., Tan Z., Niu B., Tsang K.Y., Melhado I.G., Zhong M. and Chan D., Transcriptional control of chondrocyte differentiation and their adaptation to ER stress in vivo, Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012. 2012.

Wang C., Tan Z., Tsang K.Y., Leung K.K.H., Ron D., Chan D. and Cheah K.S.E., The Role of PERK Pathway in adaptation of Hypertrophci Chondrocytes to ER Stress. , Joint Meeting of The 45th Annual Meeting of the Japanese Society of Developmental Biologists & The 64th Annual Meeting of the Japan Society for Cell Biology , Kobe, Japan, May 28-31, 2012 . 2012.

Wang C., Tan Z., Tsang K.Y., Leung K.K.H., Chan D. and Cheah K.S.E., (The Best Poster Award) The role of PERK pathway in adaptation of hypertrophic condrocytes to ER stress, Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012.. 2012.

Wang C., Tan Z., Tsang K.Y., Leung K.K.H., Chan D. and Cheah K.S.E., The role of PERK pathway in adaptation of hypertrophic chondrocytes to ER stress, Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012.. 2012.

Yao Q., Ng V.C.W., Tan Z., Chan W.C.W., Tsang K.Y., Cheah K.S.E. and Chan D., Interplay between ER stree and hypoxia pathways in chondrocytes, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Researcher : Tan Z

List of Research Outputs

Researcher : Tang HMV

List of Research Outputs

Kong K.Y., Tang H.M.V., Jin D. and Wong C.M., Yeast TRAMP complex facilitates pre-mRNA splicing, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Researcher : Tang VHM

Project Title:	Anti-HBV potential of Metformin and the mechanism of action
Investigator(s):	Tang VHM, Jin D
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	03/2012

List of Research Outputs

Kong K.Y., Tang V.H.M., Jin D. and Wong C.M., Yeast Pre-mRNA splicing is facilitated by a RNA surveillance complex, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Tang V.H.M., Siu Y.T., Chan C.P., Ching Y.P., Kok K.H. and Jin D., LKB1 tumor suppressor is a negative regulator of Tax-mediated transcriptional activation of human T-cell leukemia virus type 1 long terminal repeats, 13th SCBA International Symposium. Society of Chinese Bioscientists in America (SCBA). Guangzhou, China. 2011.

Tang V.H.M., Ming K. Jeang Scholarship Award, Society of Chinese Bioscientists in America. 美洲華人生物科學學會, 2011.

Tang V.H.M., Siu Y.T., Chan C.P., Kok K.H. and Jin D., STK11 inhibits transcriptional activation of HTLV-I LTR by Tax transactivator, The 70th Annual Meeting of the Japanese Cancer Association (JCA). 2011.

Tang V.H.M., Travel Grant Award, The 70th Annual Meeting of the Japanese Cancer Association. 2011.

Yuen K.S., Tang V.H.M., Kok K.H. and Jin D., Adenoviral delivery of RNA decoys restores expression of proapoptotic protein PUMA in Nasopharyngeal carcinoma cell by silencing of epstein-barr virus-encoded antiapoptotic miR-BART5, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Researcher : Tanner J.A.

Project Title:	Comparative Characterization of the Two Polyphosphate Kinases of M. tuberculosis
Investigator(s):	Tanner JA
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2005

Project Title:	New approaches in the nuclear delivery and targeting of aptamers to augment osteoblast activity for osteoporosis
Investigator(s):	Tanner JA, Chan D
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2010

Project Title:	Investigation of the interplay of polyphosphates and matrix vesicles in bone mineralization
Investigator(s):	Tanner JA, Li L
Department:	Biochemistry
Source(s) of Funding:	France/Hong Kong Joint Research Scheme - Travel Grants
Start Date:	01/2011
Completion Date:	12/2011

Project Title:	enGENEious Nucleic Acid Aptamers for Sensing Applications - Aptamers for Diagnosing Malaria
Investigator(s):	Tanner JA
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2012

Project Title:	Development and comparison of three new methodologies for more effective DNA aptamer evolution
Investigator(s):	Tanner JA
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

List of Research Outputs

Researcher : Tanner JA

Project Title:	Comparative Characterization of the Two Polyphosphate Kinases of M. tuberculosis
Investigator(s):	Tanner JA
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2005

Project Title:	New approaches in the nuclear delivery and targeting of aptamers to augment osteoblast activity for osteoporosis
Investigator(s):	Tanner JA, Chan D
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2010

Project Title:	Investigation of the interplay of polyphosphates and matrix vesicles in bone mineralization
Investigator(s):	Tanner JA, Li L
Department:	Biochemistry
Source(s) of Funding:	France/Hong Kong Joint Research Scheme - Travel Grants
Start Date:	01/2011
Completion Date:	12/2011

Project Title:	enGENEious Nucleic Acid Aptamers for Sensing Applications - Aptamers for Diagnosing Malaria
Investigator(s):	Tanner JA
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2012

Project Title:	Development and comparison of three new methodologies for more effective DNA aptamer evolution
Investigator(s):	Tanner JA
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

List of Research Outputs

Albano D.R.B., Tanner J.A. and Fung Y.S., An aptamer-based piezoelectric quartaz crystal biosensor for sars coronavirus helicase, 27th Philippines Chemistry Congress (27PCC0, Manila, Philippines, April 11-13, 2012 . 2012, P21-BI-O2, p.100-101.

Albano D.R.B., Tanner J.A. and Fung Y.S., Aptamer-based piezoelectric quartz crystal biosensor for SARS coronavirus helicase, The 14th Beijing Conference and Exhibition on Instrumental Analysis (BCEIA 2011), Beijing, China, October 13-16, 2011. Abstract, G33 p.881-882.

Ao K.L., Shum K.T. and Tanner J.A., Dissecting the mechanism of binding between polyphosphate and polyphosphate kinase 2, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Chan W.L., Choi M.Y., Chan C.C.Y., Chan D., Yu S.S.B., Cheah K.S.E. and Tanner J.A., Sedlin and prostaglandin E2 dehydrogenase – interactions and implications for spondyloepiphyseal dysplasia tarda,, International Congress on Research of Rare and Orphan Diseases, Basel, Switzerland, 29 February-2 March 2012.. 2012.

Chan W.L., Choi M.Y., Chan C.C.Y., Chan D., Yu S.S., Cheah K.S.E. and Tanner J.A., Sedlin and prostaglandin E2 dehydrogenase – interactions and implications for spondyloepiphyseal dysplasia tarda, RE(ACT) Congress, Basel, Switzerland . 2012.

Cheung Y.W. and Tanner J.A., Aptamers against P. falciparum histidine rich protein 2 as a new approach to malaria diagnosis. , Croucher Advanced Study Institute (ASI) ‘Structure-based screening and design of ligands for protein targets’, Chinese University of Hong Kong. 2011.

Cheung Y.W. and Tanner J.A., Detection of Plasmodium falciparum lactate dehydrogenase by Aptamer-nanoparticle conjugates, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Choi M.Y., Wong L.Y., Wang Y., Chen W., Tanner J.A. and Watt R.M., Biochemical characterization of Gppa-ppx homologues from Mycobacterium tuberculosis, 25th IADS-SEA Division Scientific Meeting, Singapore. 2011.

Choi M.Y., Wong L.Y., Tanner J.A. and Watt R.M., Characterization and mutational analysis of an exopolyphosphatase from Mycobacterium smegmatis, 25th IADS-SEA Division Scientific Meeting, Singapore. 2011.

Tanner J.A., Chasing Ehrlich’s Magic Bullet – Nucleic acid aptamers for therapy and diagnostics, Croucher Advanced Study Institute (ASI) ‘Structure-based screening and design of ligands for protein targets’, Chinese University of Hong Kong.. 2011.

Tanner J.A. and Cheung Y.W., DNA aptamers against plasmodium lactate dehydrogenase and histidine-rich protein II for malaria diagnosis and therapy, US Provisional Patent. 2012, 61/596774.

Tanner J.A., HKU Strategic Research Theme for Development and Reproduction Best Research Output Prize 2008-2011, Third Prize, 2011.

Tanner J.A., Shum K.T. and Chan S.L.C., High-affinity nucleic acid aptamers against sclerostin protein, PCT Patent. 2011, WO2011/147193.

Tanner J.A., Medical Faculty Teaching Medal 2011, Faculty of Medicine HKU. 2011.

Tanner J.A., Member of the Editorial Board, Current Chemical Biology. 2012.

Tanner J.A., Kinghorn A.B. and Cheung Y.W., Nucleic Acid Aptamers for Sensing Applications – Aptamers for Diagnosing Malaria, EnGENEious, Oxford University, UK . 2012.

Tanner J.A., The softer art of enzymology, Bioessays. 2012, 34: 83-84.

Tucker W.O. and Tanner J.A., DNA APTAMERS AS INHIBITORS OF E3 UBIQUITIN LIGASE WWP1, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Tucker W.O., Shum K.T. and Tanner J.A., G-quadruplex DNA Aptamers and their Ligands: Structure, Function and Application, Current Pharmaceutical Design. 2012, 18: 2014-2026.

Tucker W.O. and Tanner J.A., The development of therapeutic DNA aptamers against various E3 ubiquitin ligase WWP1 truncations, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Yu Y. and Tanner J.A., Developing a new approach to degenerative disc disease therapy: DNA aptamers to inhibit aggrecanases, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.. 2012.

Zong M., Satoh A., Yu M.K., Siu K.Y., Ng W.Y., Chan H.C., Tanner J.A. and Yu S., TRAPPC9 Mediates the Interaction between p150Glued and COPII Vesicles at the Target Membrane, PLoS ONE . 2012, 7(1): e29995.

Zong M., Wu X.G., Chan W.L., Choi M.Y., Chan H.C., Tanner J.A. and Yu S., The adaptor function of TRAPPC2 in mammalian TRAPPs explains TRAPPC2-associated SEDT and TRAPPC9-associated congenital intellectual disability, PLoS ONE. 2011, 6 (8): e23350.

Researcher : Tsang KY

Project Title:	The Role of Fibroblast Growth Factor 21 in ER Stress-Induced Skeletal Dysplasia
Investigator(s):	Tsang KY, Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	02/2011

List of Research Outputs

Chan W.C.W., Tsang K.Y., Ng V.C.W., Boot-Handford R., Cheah K.S.E. and Chan D., Activating ER-stress in differentiating osteocytes impairs maturation causing hyperostosis in mice , Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012.. 2012.

Cheah K.S.E., Wang C., Tan Z., Niu B., Tsang K.Y., Melhado I.G., Zhang M.Q. and Chan D., Transcriptional control of chondrocyte differentiation and their adaptation to ER stress in vivo , Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012.

Cheah K.S.E., Wang C., Tan Z., Niu B., Tsang K.Y., Melhado I.G., Zhong M. and Chan D., Transcriptional control of chondrocyte differentiation and their adaptation to ER stress in vivo, Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012. 2012.

Chu T.L., Tsang K.Y. and Cheah K.S.E., The role of MT1-MMP in regulating lineage progression of chondrocytes , 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012. . 2012.

Wang C., Tan Z., Tsang K.Y., Leung K.K.H., Ron D., Chan D. and Cheah K.S.E., The Role of PERK Pathway in adaptation of Hypertrophci Chondrocytes to ER Stress. , Joint Meeting of The 45th Annual Meeting of the Japanese Society of Developmental Biologists & The 64th Annual Meeting of the Japan Society for Cell Biology , Kobe, Japan, May 28-31, 2012 . 2012.

Wang C., Tan Z., Tsang K.Y., Leung K.K.H., Chan D. and Cheah K.S.E., (The Best Poster Award) The role of PERK pathway in adaptation of hypertrophic condrocytes to ER stress, Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012.. 2012.

Wang C., Tan Z., Tsang K.Y., Leung K.K.H., Chan D. and Cheah K.S.E., The role of PERK pathway in adaptation of hypertrophic chondrocytes to ER stress, Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012.. 2012.

Wang M., Tsang K.Y., Au Y.K., Guo S., Chan D. and Cheah K.S.E., The role of Prkci in the development of notochord, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Yao Q., Ng V.C.W., Tan Z., Chan W.C.W., Tsang K.Y., Cheah K.S.E. and Chan D., Interplay between ER stree and hypoxia pathways in chondrocytes, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Yuan Q.J., Su H., Guo J.S., Tsang K.Y., Cheah K.S.E., Chiu K.I.N., Yang J., Wong W.M., So K.F., Huang J., Wu W. and Lin Z.X., Decreased c-Jun expression correlates with impaired spinal motoneuron regeneration in aged mice following sciatic nerve crush., Exp Gerontol. Elsevier Inc., 2012, 47: 329-36.

Researcher : Tsang SL

List of Research Outputs

Leung C., Chan S.C.L., Tsang S.L., Wu W. and Sham M.H., Cyb26b1 mediates differential regulation of RA signaling in neural progenitor populations along the anterior-posterior axis of the adult spinal cord, Days of Molecular Medicine 2011, Re-engineering Regenerative Medicine, Hong Kong, 10-12 November 2011.

Leung C., Chan S.C.L., Tsang S.L., Wu W. and Sham M.H., Cyp26b mediates differential neurogenicity in axial-specific populations of adult spinal cord progenitor cells., Stem Cells and Development. 2012, Epub ahead of print.

Researcher : Tsang SW

Project Title:	Consequences of activation of canonical Wnt signaling pathway in hypertrophic chondrocytes and their descendents in vivo
Investigator(s):	Tsang SW, Cheah KSE
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	01/2012

Project Title:	Bone and Cartilage: from Development to Human Diseases Loss of β-catenin in hypertrophic chondrocytes results in abnormal bone formation
Investigator(s):	Tsang SW
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2012
Completion Date:	06/2012

List of Research Outputs

Tsang S.W., Yang Y.Z., Chan D. and Cheah K.S.E., Loss of b-Catenin in hypertrophic chondrocytes results in abnormal bone formation, Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012.. 2012.

Tsang S.W., Yang Y.Z., Chan D. and Cheah K.S.E., Loss of β-catenin in hypertrophic chondrocytes results in abnormal bone formation., Cold Spring harbor Conferences Asia – Bone & Cartilage: From Development to Human Diseases, 11-15 June 2012, Suzhou, China.. 2012.

Researcher : Tsui YP

List of Research Outputs

Cai S., Shea G.K.H., Tsui Y.P., Chan Y.S. and Shum D.K.Y., Derivation of clinically applicable schwann cells from bone marrow stromal cells for neural repair and regeneration., CNS Neurol Disord Drug Targets. 2011, 11: 500-508.

Leung H.Y., Tsui Y.P., Shea G.K.H., Tai W.Y.E., Chan Y.S. and Shum D.K.Y., Involvement of Neuregulin 1 Type III in the Ex Vivo Generation of Fate Committed Schwann Cells from Bone Marrow Stromal Cells, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Leung H.Y., Tsui Y.P., Shea G.K.H., Tai W.Y.E., Chan Y.S. and Shum D.K.Y., Role of neuregulin 1 type III in the generation of fate committed Schwann cells from bone marrow stromal cells, Abstracts of 7^th Int’l Symp. on Healthy Aging: Live Well, Age Well : 66. 2012.

Leung H.Y., Tsui Y.P., Shea G.K.H., Tai W.Y.E., Chan Y.S. and Shum D.K.Y., Signal involved in the switch to fate commitment of bone marrow-derived Schwann cells, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 74. 2012.

Tai W.Y.E., Shea G.K.H., Tsui Y.P., Leung H.Y., Chan Y.S. and Shum D.K.Y., Notch signaling mediates the switch to fate commitment of bone marrow-derived Schwann cells, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 74. 2012.

Tai W.Y.E., Shea G.K.H., Tsui Y.P., Leung H.Y., Tam K.W., Chan Y.S. and Shum D.K.Y., Signals Involved In The Switch To Fate Commitment Of Bone Marrow-derived Schwann Cells, Seventh International Symposium on Healthy Aging, P45. 2012.

Tai W.Y.E., Shea G.K.H., Tsui Y.P., Leung K.H., Tam K.W., Chan Y.S. and Shum D.K.Y., Signals involved in the switch to fate commitment of bone marrow-derived Schwann cells, Abstracts of 7^th Int’l Symp. on Healthy Aging: Live Well, Age Well : 70. 2012.

Tsui Y.P., Li R.S., Lo A.C.Y., Chan Y.S. and Shum D.K.Y., Derivation of oligodendrocyte precursors from bone marrow stromal cells for myelination therapy, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong: 72. 2012.

Tsui Y.P., Li S.Y., Lo A.C.Y., Chan Y.S. and Shum D.K.Y., Derivation of oligodendrocyte precursors from bone marrow stromal cells for remyelination therapy, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Tsui Y.P., Li S.Y., Lo A.C.Y., Chan Y.S. and Shum D.K.Y., Generation of oligodendrocyte precursors from bone marrow stromal cells for remyelination therapy, Abstracts of 7^th Int’l Symp. on Healthy Aging: Live Well, Age Well : 65.. 2012.

Researcher : Tsui YP

List of Research Outputs

Researcher : Tucker WO

List of Research Outputs

Tucker W.O. and Tanner J.A., DNA APTAMERS AS INHIBITORS OF E3 UBIQUITIN LIGASE WWP1, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Tucker W.O., Shum K.T. and Tanner J.A., G-quadruplex DNA Aptamers and their Ligands: Structure, Function and Application, Current Pharmaceutical Design. 2012, 18: 2014-2026.

Tucker W.O. and Tanner J.A., The development of therapeutic DNA aptamers against various E3 ubiquitin ligase WWP1 truncations, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Researcher : Tung WT

List of Research Outputs

Tung W.T., Chan Y.S. and Shum D.K.Y., ALIGNED CHITOSAN NANO-FIBERS FOR NERVE REGENERATION, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Tung W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Preparation of Chitosan Fibers for Nerve Regeneration, Hong Kong-Taiwan Physiology Symposium 2012 and Joint Scientific Meeting of Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong, P63. 2012.

Tung W.T., Tam K.W., Chan Y.S. and Shum D.K.Y., Preparation of chitosan fibers for nerve regeneration, Abstracts of Joint Scientific Meeting of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong : 75. 2012.

Researcher : Tung WT

List of Research Outputs

Researcher : Wang C

Project Title:	CSH-Asia Conference-Bone & Cartilage: From Development to Human Diseases The role of PERK pathway in adaptation of hypertrophic chondrocytes to ER stress
Investigator(s):	Wang C
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2012
Completion Date:	06/2012

List of Research Outputs

Cheah K.S.E., Wang C., Tan Z., Niu B., Tsang K.Y., Melhado I.G., Zhang M.Q. and Chan D., Transcriptional control of chondrocyte differentiation and their adaptation to ER stress in vivo , Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012.

Cheah K.S.E., Wang C., Tan Z., Niu B., Tsang K.Y., Melhado I.G., Zhong M. and Chan D., Transcriptional control of chondrocyte differentiation and their adaptation to ER stress in vivo, Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012. 2012.

Wang C., Tan Z., Tsang K.Y., Leung K.K.H., Ron D., Chan D. and Cheah K.S.E., The Role of PERK Pathway in adaptation of Hypertrophci Chondrocytes to ER Stress. , Joint Meeting of The 45th Annual Meeting of the Japanese Society of Developmental Biologists & The 64th Annual Meeting of the Japan Society for Cell Biology , Kobe, Japan, May 28-31, 2012 . 2012.

Wang C., Tan Z., Tsang K.Y., Leung K.K.H., Chan D. and Cheah K.S.E., (The Best Poster Award) The role of PERK pathway in adaptation of hypertrophic condrocytes to ER stress, Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012.. 2012.

Wang C., APDBN Travel Award, The Asia-Pacific Developmental Biology Network . 2012.

Wang C., Tan Z., Tsang K.Y., Leung K.K.H., Chan D. and Cheah K.S.E., The role of PERK pathway in adaptation of hypertrophic chondrocytes to ER stress, Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012.. 2012.

Researcher : Wang JJ

Project Title:	Evolution and functional specialization of alternative promoters in humans
Investigator(s):	Wang JJ, Huang J
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2009

Project Title:	FastPval: a fast and memory efficient program to calculate very low p-values from empirical distribution
Investigator(s):	Wang JJ
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	10/2010
Completion Date:	09/2011

Project Title:	A Novel Hidden Markov Model to Predict microRNAs and their Targets Simultaneously and its Application to the Epstein-Barr virus
Investigator(s):	Wang JJ, Tsao GSW
Department:	Biochemistry
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2011

Project Title:	Understanding genetic and epigenetic features of active promoters in human/mouse embryonic stem cells
Investigator(s):	Wang JJ
Department:	Biochemistry
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2011
Completion Date:	12/2012

Project Title:	Understanding the co-evolutionary relationship between transcription factors and their DNA binding sites for bHLH family in eukaryotes
Investigator(s):	Wang JJ, Yao KM
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2011

Project Title:	A computational framework to detect SNPs from next-generation sequencing data
Investigator(s):	Wang JJ, Sham PC
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2012

Project Title:	BIT's 2nd Annual World Congress of Molecular & Cell Biology Integrative analysis of high throughput genomic data for network construction
Investigator(s):	Wang JJ
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2012

List of Research Outputs

Li J., Wang P., Liu X., Lim E.L., Wang Z., Yeager M., Wong M.P., Sham P.C., Chanock S.J. and Wang J.J., GWASdb: a database for human genetic variants identified by genome-wide association studies, Nucleic Acids Res. 2011, 40(Database issue): D1047-54.

Qin J., Li J., Wang P., Zhang M.Q. and Wang J.J., ChIP-Array: Gene Regulation Network Construction from ChIP-seq/chip and mRNA expression data, The Fifth IEEE International Conference on Systems Biology, Zhuhai, China, 2-4 September 2011.

Qin J., Li J. and Wang J.J., ProteoMir express: inferring microRNA activities from mRNA and protein expression data, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Wang J.J., A database of genetic variants in microRNA genes and their putative functional roles in gene regulation, Human Mutation. 2011, 33(1): vii.

Wang J.J., A fast and accurate SNP detection algorithm for next-generation sequencing data, Tsinghua University, Beijing, China. May 21. 2012.

Wang J.J., Bioinformatics and systems biology research in JJWangLab@HKU, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China. July 19. 2011.

Wang J.J., Co-chair for Gene Expression and Regulations Session, in CMCB-2012, May 18-22, Beijing, China., 2012.

Wang J.J., Editorial Board Member, Aug., 2011- present., TSWJ Computational Biology. 2011.

Wang J.J. and Li J., FastPval: a fast and memory efficient program to calculate very low P-values from empirical distribution, IEEE International Conference on Systems Biology, Zhuhai, China, Sept 2- 4. 2011.

Wang J.J., Integrative analysis of OMICs data for cancer genomics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, China. Jan. 31. 2012.

Wang J.J., Integrative analysis of OMICs data for cancer genomics, PUMC, Beijing, China. May 17. 2012.

Wang J.J., Integrative analysis of OMICs data for regulatory network inference, HKU-McGill Symposium, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China. May 3. 2012.

Wang J.J., Integrative analysis of high throughput data for regulatory network construction, BIT’s 2nd Annual World Congress of Molecular & Cell Biology, Beijing, China. May 18. 2012.

Wang W., Wei Z., Lam T.W. and Wang J.J., Assessment of next generation sequencing analysis tools shows lower coverage and poorer SNP-calling quality in the CpG islands and regulatory regions , FRONTIERS IN BIOMEDICAL RESEARCH, HKU,HK, 09 December 2011.

Wang W., Wei Z., Lam T.W. and Wang J.J., Assessment of next generation sequencing analysis tools shows lower coverage and poorer SNP-calling quality in the CpG islands and regulatory regions in cancer genome, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Wang W., Wei Z., Lam T.W. and Wang J.J., Next generation sequencing has lower sequence coverage and poorer SNP-detection capability in the regulatory regions, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Wang W., Zhi W., Lam T.W. and Wang J.J., Next generation sequencing has lower sequence coverage and poorer SNP-detection capability in the regulatory regions, Sci. Rep.. 2011, 1: 55.

Wang W., Wei Z.H.I., Lam T.W. and Wang J.J., Next generation sequencing has lower sequence coverage and poorer SNP-detection capability in the regulatory regions, The Fifth IEEE International conference on Systems Biology, Zhuhai, China, 02-04 September 2011.

Wang Y., Wang P., Qin J., Wang X.W., Zhang M.Q. and Wang J.J., EpiRegNet: constructing epigenetic regulatory network from high throughput gene expression data for humans, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Wang Y., Wang P., Li J., Qin J., Wang X.W., Zhang M.Q. and Wang J.J., EpiRegNet: constructing epigenetic regulatory network from high throughput gene expression data for humans, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Wang Y., Wang P., Li J., Qin J., Wang X.W., Zhang M.Q. and Wang J.J., EpiRegNet: constructing epigenetic regulatory network from high throughput gene expression data for humans, Bioinformatics of Human and Animal Genomics, Cold Spring Harbor Asia, Suzhou, China, 14-18 November 2011.

Wang Y., Wang P., Li J., Qin J., Wang X.W., Zhang M.Q. and Wang J.J., EpiRegNet: constructing epigenetic regulatory network from high throughput gene expression data for humans, The Fifth IEEE International Conference on Systems Biology, Zhuhai, China, 2-4 September 2011.

Wang Y., Wang P., Li J., Qin J., Wang X.W., Zhang M.Q. and Wang J.J., EpiRegNet: constructing epigenetic regulatory networks from high throughput gene expression data for human., Epigenetics. 2011, 6(12): 1505-12.

Wu H., Wu W., Sun H., Qin G.W., Wang H.B., Wang P., Yalamanchili H.K., Wang J.J., Tse H.F., Lau C.P., Vanhoutte P.M.G.R. and Li G.R., Acacetin causes a frequency- and use-dependent blockade of hKv1.5 channels by binding to the S6 domain. , J Mol Cell Cardiol. 2011, 51(6): 966-973.

Xu F., Wang W., Wang P., Sham P.C. and Wang J.J., A fast and accurate SNP detection algorithm for next-generation sequencing data, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Xu F., Wang W., Wang P., Sham P.C. and Wang J.J., A fast and accurate SNP detection algorithm for next-generation sequencing data, 2012 The University of Hong Kong Research Postgraduate Seminar Series, HKU, HK, 24 May 2012.

Xu F., Wang W., Wang P., Sham P.C. and Wang J.J., FaSD: A fast and accurate SNP detection algorithm for next-generation sequencing data, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Yalamanchili H.K., Xiao Q.U.A.N.-.W.U. and Wang J.J., A Novel Neural Response Algorithm for Protein Function Prediction, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Yalamanchili H.K., Xiao Q.W. and Wang J.J., NRProF: Neural Response Based Protein Function Prediction Algorithm, IEEE International Conference on Systems Biology, Zhuhai, China, Sept 2- 4. 2011, in press.

Yalamanchili H.K., Xiao Q.W. and Wang J.J., NRProF: neural response based protein function prediction algorithm, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Yang S., Yalamanchili H.K., Li X., Yao K.M., Sham P.C., Zhang M.Q. and Wang J.J., Correlated evolution of transcription factors and their binding sites, Bioinformatics. 2011, 27(21): 2972-2978.

Zhang G., Zhou B., Wang W., Zhang M., Zhao Y., Wang Z., Yang L., Zhai J., Feng C.G., Wang J.J. and Chen X., A functional single-nucleotide polymorphism in the promoter of the gene encoding interleukin 6 is associated with susceptibility to tuberculosis, J Infect Dis. 2012, 154(8): 1697-704.

Researcher : Wang M

List of Research Outputs

Wang M., Tsang K.Y., Au Y.K., Guo S., Chan D. and Cheah K.S.E., The role of Prkci in the development of notochord, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Researcher : Wang P

List of Research Outputs

Li J., Wang P., Liu X., Lim E.L., Wang Z., Yeager M., Wong M.P., Sham P.C., Chanock S.J. and Wang J.J., GWASdb: a database for human genetic variants identified by genome-wide association studies, Nucleic Acids Res. 2011, 40(Database issue): D1047-54.

Qin J., Li J., Wang P., Zhang M.Q. and Wang J.J., ChIP-Array: Gene Regulation Network Construction from ChIP-seq/chip and mRNA expression data, The Fifth IEEE International Conference on Systems Biology, Zhuhai, China, 2-4 September 2011.

Wang Y., Wang P., Qin J., Wang X.W., Zhang M.Q. and Wang J.J., EpiRegNet: constructing epigenetic regulatory network from high throughput gene expression data for humans, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Wang Y., Wang P., Li J., Qin J., Wang X.W., Zhang M.Q. and Wang J.J., EpiRegNet: constructing epigenetic regulatory network from high throughput gene expression data for humans, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Wang Y., Wang P., Li J., Qin J., Wang X.W., Zhang M.Q. and Wang J.J., EpiRegNet: constructing epigenetic regulatory network from high throughput gene expression data for humans, Bioinformatics of Human and Animal Genomics, Cold Spring Harbor Asia, Suzhou, China, 14-18 November 2011.

Wang Y., Wang P., Li J., Qin J., Wang X.W., Zhang M.Q. and Wang J.J., EpiRegNet: constructing epigenetic regulatory network from high throughput gene expression data for humans, The Fifth IEEE International Conference on Systems Biology, Zhuhai, China, 2-4 September 2011.

Wang Y., Wang P., Li J., Qin J., Wang X.W., Zhang M.Q. and Wang J.J., EpiRegNet: constructing epigenetic regulatory networks from high throughput gene expression data for human., Epigenetics. 2011, 6(12): 1505-12.

Wu H., Wu W., Sun H., Qin G.W., Wang H.B., Wang P., Yalamanchili H.K., Wang J.J., Tse H.F., Lau C.P., Vanhoutte P.M.G.R. and Li G.R., Acacetin causes a frequency- and use-dependent blockade of hKv1.5 channels by binding to the S6 domain. , J Mol Cell Cardiol. 2011, 51(6): 966-973.

Xu F., Wang W., Wang P., Sham P.C. and Wang J.J., A fast and accurate SNP detection algorithm for next-generation sequencing data, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Xu F., Wang W., Wang P., Sham P.C. and Wang J.J., A fast and accurate SNP detection algorithm for next-generation sequencing data, 2012 The University of Hong Kong Research Postgraduate Seminar Series, HKU, HK, 24 May 2012.

Xu F., Wang W., Wang P., Sham P.C. and Wang J.J., FaSD: A fast and accurate SNP detection algorithm for next-generation sequencing data, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Researcher : Wang P

List of Research Outputs

Wang Y., Wang P., Li J., Qin J., Wang X.W., Zhang M.Q. and Wang J.J., EpiRegNet: constructing epigenetic regulatory network from high throughput gene expression data for humans, Bioinformatics of Human and Animal Genomics, Cold Spring Harbor Asia, Suzhou, China, 14-18 November 2011.

Wang Y., Wang P., Li J., Qin J., Wang X.W., Zhang M.Q. and Wang J.J., EpiRegNet: constructing epigenetic regulatory network from high throughput gene expression data for humans, The Fifth IEEE International Conference on Systems Biology, Zhuhai, China, 2-4 September 2011.

Researcher : Wang W

List of Research Outputs

Wang W., Wei Z., Lam T.W. and Wang J.J., Assessment of next generation sequencing analysis tools shows lower coverage and poorer SNP-calling quality in the CpG islands and regulatory regions , FRONTIERS IN BIOMEDICAL RESEARCH, HKU,HK, 09 December 2011.

Wang W., Wei Z., Lam T.W. and Wang J.J., Assessment of next generation sequencing analysis tools shows lower coverage and poorer SNP-calling quality in the CpG islands and regulatory regions in cancer genome, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Wang W., Wei Z., Lam T.W. and Wang J.J., Next generation sequencing has lower sequence coverage and poorer SNP-detection capability in the regulatory regions, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Wang W., Zhi W., Lam T.W. and Wang J.J., Next generation sequencing has lower sequence coverage and poorer SNP-detection capability in the regulatory regions, Sci. Rep.. 2011, 1: 55.

Wang W., Wei Z.H.I., Lam T.W. and Wang J.J., Next generation sequencing has lower sequence coverage and poorer SNP-detection capability in the regulatory regions, The Fifth IEEE International conference on Systems Biology, Zhuhai, China, 02-04 September 2011.

Xu F., Wang W., Wang P., Sham P.C. and Wang J.J., A fast and accurate SNP detection algorithm for next-generation sequencing data, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Xu F., Wang W., Wang P., Sham P.C. and Wang J.J., A fast and accurate SNP detection algorithm for next-generation sequencing data, 2012 The University of Hong Kong Research Postgraduate Seminar Series, HKU, HK, 24 May 2012.

Xu F., Wang W., Wang P., Sham P.C. and Wang J.J., FaSD: A fast and accurate SNP detection algorithm for next-generation sequencing data, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Researcher : Wang X

List of Research Outputs

Hor H.H., Wang X., Hui C.C. and Sham M.H., Best Poster Award: Suppressor of fused (Su(fu)) plays domain specific function in orchestrating the maintenance and differentiation of hindbrain neural progenitor pools., 2012 Inter-University Postgraduate Symposium on Life Science, HKUST, Hong Kong, 9 June 2012. . 2012.

Hor H.H., Wang X., Hui C.C. and Sham M.H., Suppressor of fused (Su(fu)) Plays Domain Specific Function in Orchestrating The Maintenance and Differentiation of Hindbrain Neural Progenitor Pools, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Hor H.H., Wang X., Hui C.C. and Sham M.H., Suppressor of fused (Su(fu)) modulates hindbrain hedgehog signaling and neurogenesis, International Society of Developmental Neuroscience 2012: Neurodevelopment and Neurological Diseases, Mumbai, India, 11-14 January 2012.

Hor H.H., Wang X., Hui C.C. and Sham M.H., Suppressor of fused (Su(fu)) plays domain specific function in orchestrating the maintenance and differentiation of hindbrain neural progenitor pools, 2012 Inter-University Postgraduate Symposium on Life Science, HKUST, Hong Kong, 9 June 2012. . 2012.

Wang X., Cheung M.C.H., Tam P.P.L., Briscoe J. and Chan D., Molecular consequences of Indian Hedgehog mutations causing brachydactylies in chick neural tube, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Researcher : Wang X

List of Research Outputs

Researcher : Wang X

List of Research Outputs

Researcher : Wang Y

Project Title:	Molecular mechanisms underlying the hepato-protective functions of the fat cell-derived hormone adiponectin: potential roles of uncoupling protein 2
Investigator(s):	Wang Y, Xu A
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2009
Completion Date:	06/2012

Project Title:	Protective effect of lipocalin-2 deficiency on aging- and dietary obesity-induced endothelial dysfunction
Investigator(s):	Wang Y, Vanhoutte PMGR
Department:	Pharmacology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2010

Project Title:	Outstanding Young Researcher Award 2009-10
Investigator(s):	Wang Y
Department:	Pharmacology
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	12/2010

Project Title:	YY1 as a negative regulator of WNT1 gene expression: a role in mammary carcinogenesis
Investigator(s):	Wang Y, Xu A
Department:	Pharmacology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2011
Completion Date:	05/2012

Project Title:	Oxidative peptide signatures as potential diagnostic biomarkers for obesity-related diabetes and cardiovascular diseases
Investigator(s):	Wang Y, Siu AFM
Department:	Pharmacology
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	03/2012

Project Title:	SIRT1 in cardiometabolic syndrome: Does liver play a role?
Investigator(s):	Wang Y, Vanhoutte PMGR
Department:	Pharmacology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

Project Title:	The Tenth Anniversary EDHF Meeting - EDHF2012 Obesity-accelerated arterial aging: interplay between free fatty acids and lipocalin-2
Investigator(s):	Wang Y
Department:	Pharmacology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2012

Researcher : Wang Y

List of Research Outputs

Wang Y., Wang P., Qin J., Wang X.W., Zhang M.Q. and Wang J.J., EpiRegNet: constructing epigenetic regulatory network from high throughput gene expression data for humans, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Wang Y., Wang P., Li J., Qin J., Wang X.W., Zhang M.Q. and Wang J.J., EpiRegNet: constructing epigenetic regulatory network from high throughput gene expression data for humans, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Wang Y., Wang P., Li J., Qin J., Wang X.W., Zhang M.Q. and Wang J.J., EpiRegNet: constructing epigenetic regulatory network from high throughput gene expression data for humans, Bioinformatics of Human and Animal Genomics, Cold Spring Harbor Asia, Suzhou, China, 14-18 November 2011.

Wang Y., Wang P., Li J., Qin J., Wang X.W., Zhang M.Q. and Wang J.J., EpiRegNet: constructing epigenetic regulatory network from high throughput gene expression data for humans, The Fifth IEEE International Conference on Systems Biology, Zhuhai, China, 2-4 September 2011.

Wang Y., Wang P., Li J., Qin J., Wang X.W., Zhang M.Q. and Wang J.J., EpiRegNet: constructing epigenetic regulatory networks from high throughput gene expression data for human., Epigenetics. 2011, 6(12): 1505-12.

Wang Y., Lu L., Wu M.H., Chan D., Cheah K.S.E. and Cheung M.C.H., Generation of induced pluripotent stem (iPS) cells from bone- formating cells, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Wang Y., Lu L., Wu M.H., Sham M.H., Chan D., Cheah K.S.E. and Cheung K.M.C., Induction of osteo-chondroprogenitors formation during transcription factor-mediated reprogramming processes, 10th Annual Meeting of International Society for Stem Cell Research, Yokohama, Japan. Jun 13-16 2012.. 2012.

Researcher : Wang Y

List of Research Outputs

Wang Y., Wang P., Li J., Qin J., Wang X.W., Zhang M.Q. and Wang J.J., EpiRegNet: constructing epigenetic regulatory network from high throughput gene expression data for humans, Bioinformatics of Human and Animal Genomics, Cold Spring Harbor Asia, Suzhou, China, 14-18 November 2011.

Wang Y., Wang P., Li J., Qin J., Wang X.W., Zhang M.Q. and Wang J.J., EpiRegNet: constructing epigenetic regulatory network from high throughput gene expression data for humans, The Fifth IEEE International Conference on Systems Biology, Zhuhai, China, 2-4 September 2011.

Researcher : Wang Z

List of Research Outputs

Krishnan V., Chow M.Z.Y., Wang Z., Zhang L., Liu X. and Zhou Z., Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice, Proc Natl Aca Sci USA. 2011, 108: 12325-30.

Lei I.L., Sham M.H. and Wang Z., ATP-dependent chromatin remodeling complex SWI/SNF in cardiogenesis and cardiac progenitor cell development., Frontiers in biology. 2012, 7(3): 202-211.

Li J., Wang P., Liu X., Lim E.L., Wang Z., Yeager M., Wong M.P., Sham P.C., Chanock S.J. and Wang J.J., GWASdb: a database for human genetic variants identified by genome-wide association studies, Nucleic Acids Res. 2011, 40(Database issue): D1047-54.

Researcher : Wang Z

List of Research Outputs

Lei I.L., Sham M.H. and Wang Z., ATP-dependent chromatin remodeling complex SWI/SNF in cardiogenesis and cardiac progenitor cell development., Frontiers in biology. 2012, 7(3): 202-211.

Researcher : Wang Z

List of Research Outputs

Lei I.L., Sham M.H. and Wang Z., ATP-dependent chromatin remodeling complex SWI/SNF in cardiogenesis and cardiac progenitor cell development., Frontiers in biology. 2012, 7(3): 202-211.

Researcher : Wong CM

Project Title:	Identification of the novel receptors for two liver-derived endocrine Factors FGF21 and adropin
Investigator(s):	Wong CM
Department:	Medicine
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2011

Project Title:	The role of beta Klotho in regulation of metabolic homeostasis: Molecular Basis and Physiological Implications
Investigator(s):	Wong CM, Xu A
Department:	Medicine
Source(s) of Funding:	Small Project Funding
Start Date:	04/2012

List of Research Outputs

Kong K.Y., Tang V.H.M., Jin D. and Wong C.M., Yeast Pre-mRNA splicing is facilitated by a RNA surveillance complex, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Researcher : Wong EYM

List of Research Outputs

Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Best Poster Award: Sox10 is essential for neural crest invasion in cochleo-vastibular ganglion. , 2012 Inter-University Postgraduate Symposium on Life Science, HKUST, Hong Kong, 9 June 2012.. 2012.

Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Sox10 is Essential for Neural Crest Invasion in Cochlea-Vestibular Ganglion, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Chu K.H., Zhang M., Wong E.Y.M., Chan Y.S., Cheah K.S.E. and Sham M.H., Sox10 is essential for neural crest invasion in cochleo-vastibular ganglion, 2012 Inter-University Postgraduate Symposium on Life Science, HKUST, Hong Kong, 9 June 2012.

Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Sox10 is essential for neural crest invasion in cochleo-vastibular ganglion, The 3rd International Symposium on Development of the Enteric Nervous System Cells, Signals and Genes, Hong Kong, 25-28 March, 2012.

Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Sox10 mutation affects gliogenesis of the cochleo-vestibular ganglion in mouse inner ear development, Third International Sox Meeting: From Structure to Function, Grainau, Munich, Germany, 11-14 September 2011.

Researcher : Wong HLX

List of Research Outputs

Chan J.K.M., Wong H.L.X., Jin G., Liu B., Cao R., Cao Y., Lehti K., Tryggvason K. and Zhou Z., MT1-MMP Inactivates ADAM9 to Regulate FGFR2 Signaling and Calvarial Osteogenesis, Developmental Cell. 2012, 22: 1176-1190.

Chan K.M.J., Wong H.L.X., Jin G., Cao R., Cao Y., Lehti K. and Zhou Z., MT1-MMP Inactivates ADAM9 to Regulate FGFR2 Signaling in Calvarial Osteogenesis. , Developmental Cell . Cell Press, 2012, 22 (6): 1176-1190.

Wong H.L.X., Postgraduate Scholarship, Wong Ching Yee Medical Postgraduate Scholarships & YS and Christabel Lung Postgraduate Scholarship 2011/12. 2012.

Wong H.L.X., Chan K.M. and Zhou Z., The Regulation of FGF Signaling by MT1-MMP in Calvarial Osteogenesis, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Researcher : Wong NS

Project Title:	Kappa-opioid receptor mediated cellular stress response: the role of Inositol 1,4,5-trisphosphate and diacylglycerol
Investigator(s):	Wong NS, Yao KM
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2002

Project Title:	The role of glutathione metabolism in causing stress resistance of cancer cells
Investigator(s):	Wong NS
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	03/2011
Completion Date:	02/2012

Project Title:	Investigation of threshold mechanisms in cellular responses to stress
Investigator(s):	Wong NS
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2012

List of Research Outputs

Liu J., Xu A., Lam K.S.L., Wong N.S., Chen J., Shepherd P.R. and Wang Y., Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation, 18th Hong Kong International Cancer Congress. 2011.

Liu J., Xu A., Lam K.S.L., Wong N.S., Chen J., Shepherd P.R. and Wang Y., Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation, The 18th Hong Kong International Cancer Conference. 2011.

Liu J., Xu A., Lam K.S.L., Wong N.S., Chen J., Sheperd P.R. and Wang Y., Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation, The 18th Hong Kong International Cancer Conference. 2011.

Lui W.T. and Wong N.S., Functional significance of the 3'-UTR in the mRNA of the stress-inducible protein CHOP/Gadd153, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Researcher : Wu LK

List of Research Outputs

Wu L.K., Chan C.H., Ip M.S.M. and Shum D.K.Y., Heparanase Activity Facilitates Syndecan-1 Shedding in Airway Inflammation, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Researcher : Wu MH

List of Research Outputs

Hui M.N., Wu M.H., Chan K.K. and Cheung M.C.H., Investigating the role of Sox9 in human neural stem cells, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Wang Y., Lu L., Wu M.H., Chan D., Cheah K.S.E. and Cheung M.C.H., Generation of induced pluripotent stem (iPS) cells from bone- formating cells, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Wang Y., Lu L., Wu M.H., Sham M.H., Chan D., Cheah K.S.E. and Cheung K.M.C., Induction of osteo-chondroprogenitors formation during transcription factor-mediated reprogramming processes, 10th Annual Meeting of International Society for Stem Cell Research, Yokohama, Japan. Jun 13-16 2012.. 2012.

Yip K.H.R., Wu M.H., Cheah K.S.E., Chan D. and Cheung M.C.H., Identification and Characterization of Long-range SOX9 Enhancers in Limb Development, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.. 2012.

Researcher : Xie S

List of Research Outputs

Xie S. and Qian C., Structure of RPA32 Bound to SMARCAL1 Redefines the Binding Interface between RPA32 and Its Interacting Proteins, 4th Asia-Pacific NMR Symposium. 2011.

Xie S., Jakoncic J. and Qian C., UHRF1 Double Tudor Domain and the Adjacent PHD Finger Act Together to Recognize K9me3-Containing Histone H3 Tail, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Xie S., Jakoncic J. and Qian C., UHRF1 double tudor domain and the adjacent PHD finger act together to recognize K9me3-containing histone H3 tail, 2012 Gordon Research Conference on Chromatin Structure & Function. 2012.

Xie S., Jakoncic J. and Qian C., UHRF1 double tudor domain and the adjacent PHD finger act together to recognize K9me3-containing histone H3 tail, Journal of Molecular Biology. Elsevier, 2012, 415: 318-328.

Researcher : Xu F

List of Research Outputs

Xu F., Wang W., Wang P., Sham P.C. and Wang J.J., A fast and accurate SNP detection algorithm for next-generation sequencing data, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Xu F., Wang W., Wang P., Sham P.C. and Wang J.J., A fast and accurate SNP detection algorithm for next-generation sequencing data, 2012 The University of Hong Kong Research Postgraduate Seminar Series, HKU, HK, 24 May 2012.

Xu F., A fast and accurate SNP detection algorithm for next-generation-sequencing data, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Xu F., Wang W., Wang P., Sham P.C. and Wang J.J., FaSD: A fast and accurate SNP detection algorithm for next-generation sequencing data, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Researcher : Xue W

List of Research Outputs

Gan H., Zhu G., Xue W., Chan D., Cheah K.S.E. and Huang J., Kinesin-1 is necessary for cytokinesis in chondrocytes, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.. 2012.

Gan H., Zhu G., Xue W., Chan D., Cheah K.S.E. and Huang J., Kinesin-1 is necessary for cytokinesis in chondrocytes, Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012.. 2012.

Gan H., Zhu G., Xue W., Chan D., Cheah K.S.E. and Huang J., Roles of kinesin-1 mediated intracellular transport in skeletal development, Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012.. 2012.

Researcher : Yalamanchili HK

List of Research Outputs

Wu H., Wu W., Sun H., Qin G.W., Wang H.B., Wang P., Yalamanchili H.K., Wang J.J., Tse H.F., Lau C.P., Vanhoutte P.M.G.R. and Li G.R., Acacetin causes a frequency- and use-dependent blockade of hKv1.5 channels by binding to the S6 domain. , J Mol Cell Cardiol. 2011, 51(6): 966-973.

Yalamanchili H.K., Xiao Q.U.A.N.-.W.U. and Wang J.J., A Novel Neural Response Algorithm for Protein Function Prediction, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Yalamanchili H.K., Xiao Q.W. and Wang J.J., NRProF: Neural Response Based Protein Function Prediction Algorithm, IEEE International Conference on Systems Biology, Zhuhai, China, Sept 2- 4. 2011, in press.

Yalamanchili H.K., Xiao Q.W. and Wang J.J., NRProF: neural response based protein function prediction algorithm, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Yang S., Yalamanchili H.K., Li X., Yao K.M., Sham P.C., Zhang M.Q. and Wang J.J., Correlated evolution of transcription factors and their binding sites, Bioinformatics. 2011, 27(21): 2972-2978.

Researcher : Yang M

Project Title:	the 8th Asia Pacific Symposium on Neural Regeneration in conjunction with the 5th Pan Pacific Symposium on Stem Cells and Cancer Research & the 1st Cross-Strait Biotechnology Forum Exosomal shuttled microRNA: a new target for breast cancer therapy
Investigator(s):	Yang M
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2012
Completion Date:	04/2012

List of Research Outputs

Yang M., Chen J., Su F., Yu B., Su F.X., Lin L., Liu Y.J., Huang J. and Song E.W., Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells, Molecular Cancer . 2011, 10(1): 117.

Yu B., Yang M., Shi L., Yao Y.D., Jiang Q.Q., Li X.F., Tang L.H., Zheng B., Yuen K.Y., Smith D.K., Song E.W. and Huang J., Explicit hypoxia targeting with tumor suppression by creating an "obligate" anaerobic Salmonella Typhimurium strain , Scientific Reports . 2012, 2: 436.

Researcher : Yang S

List of Research Outputs

Yang S., Yalamanchili H.K., Li X., Yao K.M., Sham P.C., Zhang M.Q. and Wang J.J., Correlated evolution of transcription factors and their binding sites, Bioinformatics. 2011, 27(21): 2972-2978.

Researcher : Yao KM

Project Title:	Regulation of Bmi-1 expression by the Forkhead box transcription factor FoxM1
Investigator(s):	Yao KM
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	11/2007

Project Title:	Investigating the role of FOXM1 in the maintenance of human embryonic stem cell pluripotency and genome stability
Investigator(s):	Yao KM, Cheung MCH
Department:	Biochemistry
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2012

List of Research Outputs

Chan D.W., Liu V.W.S., Leung L.Y., Yao K.M., Chan K.K.L., Cheung A.N.Y. and Ngan H.Y.S., Zic2 synergistically enhances Hedgehog signalling through nuclear retention of Gli1 in cervical cancer cells, J Pathol. 2011, 225(4): 525-34.

Chong T.Y.I., Chan C.Y., Lee C.Y.L., Shiu S.Y.W., Li J.Y.H. and Yao K.M., Establishing a Cell-based Platform to identify Molecules for Directing the Differentiation of Human Embryonic Stem Cells into Insulin-secreting β-like cells, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Li C., Liu V.W.S., Chan D.W., Yao K.M. and Ngan H.Y.S., LY294002 and Metformin Cooperatively Enhance the Inhibition of Growth and the Induction of Apoptosis of Ovarian Cancer Cells., Int J Gynecol Cancer.. 2011, 22: 15-22.

Lok T.M., Chan D.W., Liu V.W.S., Hui W.Y., Leung T.H.Y., Yao K.M. and Ngan H.Y.S., Aberrant Activation of ERK/FOXM1 Signaling Cascade Triggers the Cell Migration/Invasion in Ovarian Cancer Cells, PLoS One. 2011, 6: e23790.

Ngan W.L. and Yao K.M., EPS8 and FOXM1 - Do they mesh to promote carcinogenesis?, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Shiu S.Y.W., Leung W.Y.G., Tam C.W., Liu V.W.S. and Yao K.M., Melatonin MT(1) receptor-induced transcriptional up-regulation of p27(Kip1) in prostate cancer antiproliferation is mediated via inhibtion of constitutively active nuclear factor kappa B (NF-kB): potential implications on prostate cancer chemoprevention and therapy, J Pineal Res. 2012, 54 (Jan 2013): 69-79.

Yang S., Yalamanchili H.K., Li X., Yao K.M., Sham P.C., Zhang M.Q. and Wang J.J., Correlated evolution of transcription factors and their binding sites, Bioinformatics. 2011, 27(21): 2972-2978.

Researcher : Yao Q

List of Research Outputs

Yao Q., Ng V.C.W., Tan Z., Chan W.C.W., Tsang K.Y., Cheah K.S.E. and Chan D., Interplay between ER stree and hypoxia pathways in chondrocytes, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Researcher : Yip KHR

List of Research Outputs

Yip K.H.R., Wu M.H., Cheah K.S.E., Chan D. and Cheung M.C.H., Identification and Characterization of Long-range SOX9 Enhancers in Limb Development, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.. 2012.

Researcher : Yip MS

Project Title:	Role of type II collagen cleavage and immune responses in intervertebral disc degeneration in vivo
Investigator(s):	Yip MS, Chan D
Department:	Biochemistry
Source(s) of Funding:	Small Project Funding
Start Date:	05/2012

Researcher : Yu B

List of Research Outputs

Yang M., Chen J., Su F., Yu B., Su F.X., Lin L., Liu Y.J., Huang J. and Song E.W., Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells, Molecular Cancer . 2011, 10(1): 117.

Yu B., Yang M., Shi L., Yao Y.D., Jiang Q.Q., Li X.F., Tang L.H., Zheng B., Yuen K.Y., Smith D.K., Song E.W. and Huang J., Explicit hypoxia targeting with tumor suppression by creating an "obligate" anaerobic Salmonella Typhimurium strain , Scientific Reports . 2012, 2: 436.

Zhang K., Yu B., Cao T., Zhang N. and Huang J., A preliminary study for development of oral vaccines for poultry and wild birds against avian H5N1 influenza virus, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Researcher : Yu B

List of Research Outputs

Researcher : Yu Y

List of Research Outputs

Yu Y. and Tanner J.A., Developing a new approach to degenerative disc disease therapy: DNA aptamers to inhibit aggrecanases, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.. 2012.

Researcher : Yuen KS

List of Research Outputs

Yuen K.S., Tang V.H.M., Kok K.H. and Jin D., Adenoviral delivery of RNA decoys restores expression of proapoptotic protein PUMA in Nasopharyngeal carcinoma cell by silencing of epstein-barr virus-encoded antiapoptotic miR-BART5, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Researcher : Zhang L

List of Research Outputs

Chan W.C.W., Zhang L., Chan W.Y., Cheah K.S.E. and Chan D., Cells in the endplate cartilage contribute to the inner annulus fibrosus in the intervertebral disc, World Forum for Spine Research 2012: The Intervertebral Disc- from Degeneration to Pain, Helsinki, Finland, 18-21, 2012.

Krishnan V., Chow M.Z.Y., Wang Z., Zhang L., Liu X. and Zhou Z., Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice, Proc Natl Aca Sci USA. 2011, 108: 12325-30.

Researcher : Zhang L

List of Research Outputs

Researcher : Zhang M

List of Research Outputs

Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Best Poster Award: Sox10 is essential for neural crest invasion in cochleo-vastibular ganglion. , 2012 Inter-University Postgraduate Symposium on Life Science, HKUST, Hong Kong, 9 June 2012.. 2012.

Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Sox10 is Essential for Neural Crest Invasion in Cochlea-Vestibular Ganglion, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Chu K.H., Zhang M., Wong E.Y.M., Chan Y.S., Cheah K.S.E. and Sham M.H., Sox10 is essential for neural crest invasion in cochleo-vastibular ganglion, 2012 Inter-University Postgraduate Symposium on Life Science, HKUST, Hong Kong, 9 June 2012.

Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Sox10 is essential for neural crest invasion in cochleo-vastibular ganglion, The 3rd International Symposium on Development of the Enteric Nervous System Cells, Signals and Genes, Hong Kong, 25-28 March, 2012.

Chu K.H., Zhang M., Wong E.Y.M., Szeto Y.Y., Chan Y.S., Cheah K.S.E. and Sham M.H., Sox10 mutation affects gliogenesis of the cochleo-vestibular ganglion in mouse inner ear development, Third International Sox Meeting: From Structure to Function, Grainau, Munich, Germany, 11-14 September 2011.

Zhang M., Leung C., Sit H.M., Chu K.H., Lui V.C.H., Tam P.K.H. and Sham M.H., Sox10 ^NGFP mutation affects migration of enteric neural cress cells in mouse embryonic gut, The 3rd International Symposium on Development of the Enteric Nervous System Cells, Signals and Genes, Hong Kong, 25-28 March, 2012.

Researcher : Zhang M

List of Research Outputs

Researcher : Zhong M

List of Research Outputs

Cheah K.S.E., Wang C., Tan Z., Niu B., Tsang K.Y., Melhado I.G., Zhong M. and Chan D., Transcriptional control of chondrocyte differentiation and their adaptation to ER stress in vivo, Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012. 2012.

Researcher : Zhou J

List of Research Outputs

Zhou J. and Zhou Z., Loss of MT1-MMP Facilitates iPSCs self-renewal, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Zhou J. and Zhou Z., Loss of MT1-MMP influences CNS development, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Researcher : Zhou Z

Project Title:	Understanding the regulation of MT1-MMP activity in tumorigenesis
Investigator(s):	Zhou Z
Department:	Biochemistry
Source(s) of Funding:	Matching Fund for NSFC Young Researcher Award
Start Date:	05/2006

Project Title:	Screening anti-ageing substances in small chemical library using premature ageing animals
Investigator(s):	Zhou Z
Department:	Biochemistry
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	09/2007

Project Title:	Regulation of FGFR signaling by MT1-MMP
Investigator(s):	Zhou Z
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2008
Completion Date:	02/2012

Project Title:	Ageing and longevity: biology and challenge
Investigator(s):	Zhou Z
Department:	Biochemistry
Source(s) of Funding:	Croucher Advanced Study Institute
Start Date:	02/2009

Project Title:	Stem Cells and the Key signaling Pathways in Bone Aging and Regeneration
Investigator(s):	Zhou Z
Department:	Biochemistry
Source(s) of Funding:	Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:	03/2011

Project Title:	Isthmin In Fibroblast Growth Factor Signaling and Nodal Signaling during Embryogenesis and Development
Investigator(s):	Zhou Z
Department:	Biochemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2011

Project Title:	Gordon Research Conference on Matrix Metalloproteinases MT1-MMP regulates Notch signaling to maintain B lymphocyte development
Investigator(s):	Zhou Z
Department:	Biochemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2011
Completion Date:	08/2011

Project Title:	MT1-MMP regulates neural stem cell self-renewal and differentiation
Investigator(s):	Zhou Z
Department:	Biochemistry
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2012

List of Research Outputs

Chan J.K.M., Wong H.L.X., Jin G., Liu B., Cao R., Cao Y., Lehti K., Tryggvason K. and Zhou Z., MT1-MMP Inactivates ADAM9 to Regulate FGFR2 Signaling and Calvarial Osteogenesis, Developmental Cell. 2012, 22: 1176-1190.

Chan K.M.J., Wong H.L.X., Jin G., Cao R., Cao Y., Lehti K. and Zhou Z., MT1-MMP Inactivates ADAM9 to Regulate FGFR2 Signaling in Calvarial Osteogenesis. , Developmental Cell . Cell Press, 2012, 22 (6): 1176-1190.

Kar B., Liu B., Zhou Z. and Lam Y.W., Quantitative nucleolar proteomics reveals nuclear re-organization during stress-induced senescence in mouse fibroblast. , BMC Cell Biology . 2011.

Krishnan V., Liu B. and Zhou Z., 'Relax and Repair' to restrain aging, Aging. 2011, 3(10): 943-954.

Krishnan V., Liu B. and Zhou Z., DNA Repair, Human Diseases and Aging , In: Sonya Vengrova, DNA Repair and Human Health . INTECH, 2011, 1-40.

Krishnan V., Chow M.Z.Y., Wang Z., Zhang L., Liu X. and Zhou Z., Histone H4 lysine 16 hypoacetylation is associated with defective DNA repair and premature senescence in Zmpste24-deficient mice, Proc Natl Aca Sci USA. 2011, 108: 12325-30.

Liu B., Jin D. and Zhou Z., From loss to gain: role for SUN1 in laminopathies, Cell & Bioscience. 2012, 2: 21.

Wong H.L.X., Chan K.M. and Zhou Z., The Regulation of FGF Signaling by MT1-MMP in Calvarial Osteogenesis, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Zhou J. and Zhou Z., Loss of MT1-MMP Facilitates iPSCs self-renewal, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Zhou J. and Zhou Z., Loss of MT1-MMP influences CNS development, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.

Zhou Z., Academic Editor, PLoS ONE. 2012.

Zhou Z., Biochemistry and Analytical Biochemistry. 2011.

Zhou Z., MT1-MMP cleaves Dll1 to regulate Notch signalling to maintain normal B lymphocyte development , Gordon Research Conference on Matrix Metalloproteinase. USA, 2011 Aug 7-12. 2011.

Zhou Z., Stem cells and aging , UK-HK Frontier of Science Royal Society, Croucher Foundation. 2011.

Researcher : Zhu G

List of Research Outputs

Gan H., Zhu G., Xue W., Chan D., Cheah K.S.E. and Huang J., Kinesin-1 is necessary for cytokinesis in chondrocytes, 2012 Hong Kong Inter-University Postgraduate Symposium on Life Science, The Hong Kong University of Science and Technology, 9 June 2012.. 2012.

Gan H., Zhu G., Xue W., Chan D., Cheah K.S.E. and Huang J., Kinesin-1 is necessary for cytokinesis in chondrocytes, Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012.. 2012.

Gan H., Zhu G., Xue W., Chan D., Cheah K.S.E. and Huang J., Roles of kinesin-1 mediated intracellular transport in skeletal development, Cold Spring Harbor Asia Meeting on " Bone and Cartilage: from Development to Human Diseases, Suzhou, China, 11-15 June, 2012.. 2012.

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