Dept of Microbiology

DEPT OF MICROBIOLOGY

Researcher : Ang L

Project Title:	Investigation of the Evolution Mechanism(s) and Changes in Antimicrobial Resistance Pattern of the Emerging Non-Vaccine Serotypes (NVT) of Streptococcus pneumoniae After the Introduction of Pneumococcal Conjugate Vaccine (PCV-7) in Hong Kong
Investigator(s):	Ang L, Ho PL
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2010
Completion Date:	10/2011

List of Research Outputs

Chiu S.S.S., Lau Y.L., Ho P.L., Ang L., Chow K.H. and Chan M.Y., Changes in nasopharyngeal carriage and serotype distribution of antibiotic-resistant Streptococcus pneumonias before and after the introduction of 7-valent pneumococcal conjugate vaccine in Hong Kong, Diagnostic Microbiology and Infectious Disease. 2011, 71(4).

Researcher : Bai R

List of Research Outputs

Lau S.K.P., Woo P.C.Y., Yeung C., Teng L.L., Wu Y., Bai R., Fan Y.Y., Chan K.H. and Yuen K.Y., Identification and characterization of bocaviruses in cats and dogs revealed a novel feline bocavirus and a novel genetic group of canine bocavirus, Journal of General Virology. 2012, 93: 1573-1582.

Lau S.K.P., Woo P.C.Y., Yip C.Y., Choi K.Y., Wu Y., Bai R., Fan Y.Y., Lai K.Y., Chan K.H. and Yuen K.Y., Identification of a novel feline picornavirus from the domestic cat, Journal of Virology . 2011, 86: 395-405.

Woo P.C.Y., Lau S.K.P., Bai R., Teng L.L., Lee P., Martelli P., Hui S.W. and Yuen K.Y., Complete genome sequence of a novel picobirnavirus, otarine picobirnavirus, discovered in California sea lions, Journal of Virology. 2012, 86: 6377-6378.

Woo P.C.Y., Lau S.K.P., Lam S.F., Lau C.Y., Tsang K.L., Lau J.H.N., Bai R., Teng L.L., Tsang C.C.C., Wang M., Zheng B., Chan K.H. and Yuen K.Y., Discovery of seven novel mammalian and avian coronaviruses in Deltacoronavirus supports bat coronaviruses as the gene source of Alphacoronavirus and Betacoronavirus and avian coronaviruses as the gene source of Gammacoronavirus and Deltacoronavirus, Journal of Virology. 2012, 86: 3995-4008.

Researcher : Cao T

List of Research Outputs

Zhang K., Yu B., Cao T., Zhang N. and Huang J., A preliminary study for development of oral vaccines for poultry and wild birds against avian H5N1 influenza virus, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Researcher : Chan CM

List of Research Outputs

Wang Y.F., Cai J.P., Wang Y.D., Dong H., Hao W., Jiang L.X., Long J., Chan C.M., Woo P.C.Y., Lau S.K.P., Yuen K.Y. and Che X.Y., Immunoassays based on Penicillium marneffei Mp1p derived from Pichia pastoris expression system for diagnosis of penicilliosis, PLoS One. 2011, 6: e28796.

Woo P.C.Y., Lau S.K.P., Liu B., Cai J.J., Chong T.K., Tse H., Kao R.Y.T., Chan C.M., Chow W.N. and Yuen K.Y., Draft genome sequence of Penicillium marneffei strain PM1, Eukaryotic Cell. 2011, 10: 1740-1741.

Researcher : Chan JFW

List of Research Outputs

Chan J.F.W., Lau S.K.P., Curreem S.O.T., To K.K.W., Leung S.S.M., Cheng V.C.C., Yuen K.Y. and Woo P.C.Y., First report of spontaneous intrapartum Atopobium vaginae bacteremia, Journal of Clinical Microbiology. 2012, 50: 2525-2528.

Chan J.F.W., Woo P.C.Y., Teng L.L., Lau S.K.P., Leung S.S.M., Tam F.C.C. and Yuen K.Y., Primary infective spondylodiscitis caused by Lactococcus garvieae and a review of human L. garvieae infections, Infection. 2011, 39: 259-264.

Cheng V.C.C., Yam W.C., Yau M.C.Y., Siu G.K.H., Wong S.C.Y., Chan J.F.W., To K.K.W., Tse H., Hung I.F.N., Tai J.W.M., Ho P.L. and Yuen K.Y., Epidemiology Of Klebsiella Oxytoca-associated Diarrhea Detected By Simmons Citrate Agar Supplemented With Inositol, Tryptophan, And Bile Salts., J Clin Microbiol. 2012, 50(5):1571-9.

Cheng V.C.C., Yam W.C., Tsang L.L., Yau M.C.Y., Siu G.K.H., Wong S.C.Y., Chan J.F.W., To K.K.W., Tse H., Hung I.F.N., Tai J.W.M., Ho P.L. and Yuen K.Y., Epidemiology of Klebsiella oxytoca-associated diarrhea detected by Simmons citrate agar supplemented with inositol, tryptophan, and bile salts, Journal of Clinical Microbiology. 2012, 50: 1571-9.

Researcher : Chan KH

List of Research Outputs

Bahl J., Nelson M.I., Chan K.H., Chen R., Vijaykrishna D., Halpin R.A., Stockwell T.B., Lin X., Wentworth D.E., Ghedin E., Guan Y., Peiris J.S.M., Riley S., Rambaut A., Holmes E.C. and Smith G.J., Temporally structured metapopulation dynamics and persistence of influenza A H3N2 virus in humans, Proceedings of National Academic Science (USA). 2011, 108(48): 19359-64.

Chiu S.S.S., Chan K.H., So L.Y., Chen H.S.R., Chan E.L. and Peiris J.S.M., The population based socioeconomic burden of pediatric influenza-associated hospitalization in Hong Kong, Vaccine. 2012, 30(10).

Cowling B.J., Chan K.H., Klick B.A., Durrani S., Chou S.K., Wong S.T., Kam M.S., Kwok H.K.H., Ng S., Chiu S.S.S., Peiris J.S.M. and Ip D.K.M., Efficacy of live attenuated seasonal and pandemic influenza vaccine in school-age children: A randomized controlled trial (abstract), 4th ESWI Influenza Conference on 11-14 September 2011 in Malta. Malta, European Scientific Working Group on Influenza, 2011, A508P.

Cowling B.J., Fang J., Nishiura H., Chan K.H., Ng S., Ip D.K.M., Chiu S.S.S., Leung G.M. and Peiris J.S.M., Increased risk of non-influenza respiratory virus infections associated with receipt of inactivated influenza vaccine, Clinical Infectious Diseases. 2012, 54(12): 1778-83.

Ip D.K.M., Schutten M., Fang J., Fung R.O.P., Dutkowski R.T., Chan K.H., Leung G.M., Peiris J.S.M. and Cowling B.J., Validation of self-swab for virologic confirmation of influenza virus infections in a community setting, Journal of Infectious Diseases. 2012, 205(4): 631-634.

Lau L.H.L., Fang J., Chan K.H., Cheng K.Y., Leung G.M., Peiris J.S.M. and Cowling B.J., Influenza viral loads and infectivity (abstract and oral presentation), 16th Research Postgraduate Symposium on 7-8 December 2011 in Hong Kong. Hong Kong, LKS Faculty of Medicine, HKU, 2011, 3.16: 204.

Lau S.K.P., Woo P.C.Y., Lai K.Y., Huang Y., Yip C.Y., Shek C.T., Lee P., Lam S.F., Chan K.H. and Yuen K.Y., Complete genome analysis of three novel picornaviruses from diverse bat species, Journal of Virology. 2011, 85: 8819-8828.

Lau S.K.P., Woo P.C.Y., Yeung C., Teng L.L., Wu Y., Bai R., Fan Y.Y., Chan K.H. and Yuen K.Y., Identification and characterization of bocaviruses in cats and dogs revealed a novel feline bocavirus and a novel genetic group of canine bocavirus, Journal of General Virology. 2012, 93: 1573-1582.

Lau S.K.P., Woo P.C.Y., Yip C.Y., Choi K.Y., Wu Y., Bai R., Fan Y.Y., Lai K.Y., Chan K.H. and Yuen K.Y., Identification of a novel feline picornavirus from the domestic cat, Journal of Virology . 2011, 86: 395-405.

Lau S.K.P., Woo P.C.Y., Yip C.Y., Fan Y.Y., Huang Y., Wang M., Guo R., Lam S.F., Tsang K.L., Lai K.Y., Chan K.H., Che X.Y., Zheng B. and Yuen K.Y., Isolation and characterization of a novel Betacoronavirus subgroup A coronavirus, rabbit coronavirus HKU14, from domestic rabbits, Journal of Virology. 2012, 86: 5481-5496.

Lau S.K.P., Lee P., Tsang K.L., Yip C.Y., Tse H., Lee R.A., So L.Y., Lau Y.L., Chan K.H., Woo P.C.Y. and Yuen K.Y., Molecular epidemiology of human coronavirus OC43 reveals evolution of different genotypes over time and recent emergence of a novel genotype due to natural recombination., Journal of Virology. 2011, 85: 11325-11337.

Lei T., Siu K.L., Koh K.H., Chan K.H., Hung I.F.N., To K.K.W. and Yuen K.Y., Anti-ganglioside Antibodies Were Not Detected In Human Subjects Infected With Or Vaccinated Against 2009 Pandemic Influenza A (h1n1) Virus., Vaccine. 2012, 30(16):2605-10.

Lei T., Siu K.L., Kok K.H., Chan K.H., Chan E.Y.T., Hung I.F.N., To K.K.W., Li P.C.K., Zhou J., Zheng B., Yuen K.Y., Wang M. and Jin D., Anti-ganglioside antibodies were not detected in human subjects infected with or vaccinated against 2009 pandemic influenza A (H1N1) virus., Vaccine. 2012, 30: 2605-2610.

Tse H., To K.K.W., Wen X., Chen H., Chan K.H., Tsoi H.W., Li I.W.S. and Yuen K.Y., Clinical and virological factors associated with viremia in pandemic influenza A/H1N1/2009 virus infection, PLoS One. 2011, 6: e22534.

Wang X., Yang L., Chan K.P., Chiu S.S.S., Chan K.H., Peiris J.S.M. and Wong C.M., Model selection in time series studies of influenza-associated mortality, PLoS One. 2012, 7(6): e39423.

Wang X., Yang L., Chan K.P., Chiu S.S.S., Chan K.H., Peiris J.S.M. and Wong C.M., Performance of model selection criteria in time series studies of influenza-associated mortality (abstract and poster presentation), 16th Research Postgraduate Symposium on 7-8 December 2011 in Hong Kong. 2011, 4.26: 131.

Wang X., Yang L., Chan K.P., Chiu S.S.S., Chan K.H., Peiris J.S.M. and Wong C.M., Performance of three influenza activity proxy variables for estimating age-specific hospitalization associated with influenza in Hong Kong (abstract and poster presentation), Hong Kong College of Community Medicine Annual Scientific Meeting on 27 November 2011 in Hong Kong. Hong Kong, Hong Kong College of Community Medicine, 2011.

Woo P.C.Y., Lau S.K.P., Lam S.F., Lau C.Y., Tsang K.L., Lau J.H.N., Bai R., Teng L.L., Tsang C.C.C., Wang M., Zheng B., Chan K.H. and Yuen K.Y., Discovery of seven novel mammalian and avian coronaviruses in Deltacoronavirus supports bat coronaviruses as the gene source of Alphacoronavirus and Betacoronavirus and avian coronaviruses as the gene source of Gammacoronavirus and Deltacoronavirus, Journal of Virology. 2012, 86: 3995-4008.

Woo P.C.Y., Lau S.K.P., Wong B.H.L., Fan Y.Y., Wong Y.P., Zhang J., Wu Y., Choi K.Y., Li K.S.M., Hui J., Wang M., Zheng B., Chan K.H. and Yuen K.Y., Feline morbillivirus, a previously undescribed paramyxovirus associated with tubulointerstitial nephritis in domestic cats, Proceedings of the National Academy of Sciences of the USA. 2012, 109: 5435-5440.

Woo P.C.Y., Lau S.K.P., Choi K.Y., Huang Y., Teng L.L., Tsoi H.W., Tse H., Yeung M.L., Chan K.H., Jin D. and Yuen K.Y., Natural occurrence and characterization of two IRES elements in a novel virus, canine picodicistrovirus, in the picornavirus-like superfamily, Journal of Virology. 2011, 86: 2797-2808.

Wu W.L., Lau S.Y., Chen Y., Wang G., Mok B.W.Y., Wen X., Wang P., Song W., Lin T., Chan K.H., Yuen K.Y. and Chen H., 2008-2009 H1N1 influenza virus exhibits reduced susceptibility to antibody inhibition: implications for the prevalence of oseltamivir resistant variant viruses, Antiviral Research. . 2011, 93: 144-53.

Yang L., Chan K.P., Cowling B.J., Chiu S.S.S., Chan K.H., Peiris J.S.M. and Wong C.M., Estimation of mortality burden associated with 2009 pandemic H1N1 in Hong Kong (abstract), 4th ESWI Influenza Conference on 11-14 September 2011 in Malta. Malta, European Scientific Working Group on Influenza, 2011, B608P.

Yip C.Y., Lau S.K.P., Woo P.C.Y., Chan K.H. and Yuen K.Y., Complete genome sequence of a coxsackievirus A22 strain in Hong Kong reveals a natural intratypic recombination event, Journal of Virology . 2011, 85: 12098-12099.

Zhang J., To K.K.W., Tse H., Chan K.H., Hung I.F.N. and Yuen K.Y., High Incidence Of Severe Influenza Among Individuals Over 50 Years Of Age., Clin Vaccine Immunol . 2011, 18(11):1918-24.

Researcher : Chan MCW

Project Title:	Effect of vitamin B2 in the treatment of human influenza H5N1 virus infection: studies in vitro and in vivo
Investigator(s):	Chan MCW, Peiris JSM, Chan WY
Department:	Microbiology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	02/2009

Project Title:	Influenza A (H5N1) virus infection in human primary type I and type II alveolar epithelial cells: Cell tropism, inflammatory responses and apoptosis
Investigator(s):	Chan MCW, Peiris JSM
Department:	Microbiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2010

Project Title:	Effect of allogeneic human mesenchymal stem cells on alveolar fluid clearance and protein permeability in human alveolar epithelial cells injured by influenza H5N1 virus infection
Investigator(s):	Chan MCW, Nicholls JM
Department:	Microbiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2010

Project Title:	Experimental models to study the impact of cigarette smoking on the tropism of the highly pathogenic avian influenza H5N1 virus in human respiratory tract
Investigator(s):	Chan MCW, Chan WY, Nicholls JM, Mak JCW
Department:	Microbiology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	02/2011

Project Title:	Tropism and innate host responses in primary human cardiac myocytes infected with influenza H5N1 and H1N1pdm virus
Investigator(s):	Chan MCW
Department:	Microbiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2011

Project Title:	Role of indirubin-3’-oxime as an antiviral and immunomodulatory agent in the treatment of severe human influenza virus infection
Investigator(s):	Chan MCW
Department:	School of Public Health
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	03/2012

Project Title:	Therapeutic Effect of Human Umbilical Cord Mesenchymal Stem Cells on Acute Lung Injury Caused by Severe Influenza H5N1 Virus Infection
Investigator(s):	Chan MCW, Peiris JSM, Guan Y, Chan GCF, Chan WY
Department:	School of Public Health
Source(s) of Funding:	Matching Grant for Joint Research
Start Date:	05/2012

Project Title:	A comparative study of influenza A viruses with differential interferon induction with respect to their potential to confer increased susceptibility to secondary bacterial infections
Investigator(s):	Chan MCW
Department:	School of Public Health
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

List of Research Outputs

Hui P.Y., Lee M.Y., Cheung C.Y., Mao H., Lai K.W., Chan W.Y., Chan M.C.W., Tu W., Guan Y., Lau Y.L. and Peiris J.S.M., H5N1 influenza virus-induced mediators upregulate RIG-I in uninfected cells by paracrine effects contributing to amplified cytokine cascades, The Journal of Infectious Diseases. 2011, 204(12): 1866-1878.

Mok K.P., Yen H., Yu Y.M., Yuen K.M., Sia S.F., Chan M.C.W., Qin G., Tu W. and Peiris J.S.M., Amino Acid Residues 253 and 591 of the PB2 Protein of Avian Influenza Virus A H9N2 Contribute to Mammalian Pathogenesis, Journal of Virology. 2011, 85(18): 9641-9645.

Yen H., Liang C.-.H., Wu C.-.Y., Forrest H., Ferguson A., Choy K.T., Jones J., Wong D.D.Y., Cheung P.H.P., Hsu C.-.H., Li O.T.W., Yuen K.M., Chan W.Y., Poon L.L.M., Chan M.C.W., Nicholls J.M., Krauss S., Wong C.-.H., Guan Y., Webster R.G., Webby R. and Peiris J.S.M., Hemagglutinin-neuraminidase balance confers respiratory-droplet transmissibility of the pandemic H1N1 influenza virus in ferrets, Proceedings of National Academic Science (USA). 2011, 108: 14264-14269.

Yu C.L., Chan W.Y., Wang J., Travanty E.A., Nicholls J.M., Peiris J.S.M., Mason R.J. and Chan M.C.W., Viral Replication and Innate Host Responses in Primary Human Alveolar Epithelial Cells and Alveolar Macrophages Infected with Influenza H5N1 and H1N1 Viruses. , Journal of Virology. 2011, 85 (14): 6844-6855.

Researcher : Chan WM

List of Research Outputs

Tse H., Lau S.K.P., Chan W.M., Choi K.Y., Woo P.C.Y. and Yuen K.Y., Complete genome sequences of novel canine noroviruses in Hong Kong, Journal of Virology. 2012, 86: 9531-9532.

Tse H., Chan W.M., Li K.S.M., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Discovery and genomic characterization of a novel bat sapovirus with unusual genomic features and phylogenetic position, PLoS One. 2012, 7: e34987.

Tse H., Chan W.M., Tsoi H.W., Fan Y.Y., Lau C.Y., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Rediscovery and genomic characterization of bovine astroviruses, Journal of General Virology. 2011, 2011, 92: 1888-1898.

Researcher : Chan WY

Project Title:	The biological and genetic determinants of seasonal influenza A virus replication in the lower respiratory tract
Investigator(s):	Chan WY, Chan MCW, Yen H, Nicholls JM, Peiris JSM
Department:	Pathology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	02/2011

Project Title:	Neutrophil mediated host-responses during influenza A virus infection, an in vitro study
Investigator(s):	Chan WY, Chan MCW, Shum DKY, Nicholls JM, Peiris JSM
Department:	Pathology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	03/2012

Project Title:	Human primary lung microvascular endothelial responses to influenza A virus infection
Investigator(s):	Chan WY, Nicholls JM
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2012

List of Research Outputs

Hui P.Y., Lee M.Y., Cheung C.Y., Mao H., Lai K.W., Chan W.Y., Chan M.C.W., Tu W., Guan Y., Lau Y.L. and Peiris J.S.M., H5N1 influenza virus-induced mediators upregulate RIG-I in uninfected cells by paracrine effects contributing to amplified cytokine cascades, The Journal of Infectious Diseases. 2011, 204(12): 1866-1878.

Researcher : Chen C

List of Research Outputs

Fu X.-.Y., Chen C., Pan H.-.X., Huang T.A.O., Zhang M. and Zheng H.O.N.G., Inhibition of breast cancer cell proliferation and migration by monoclonal antibody m590 specific for insulin-like growth factor receptor type I , Chinese Journal of Experimental Surgery. 中华实验外科杂志, 2012, 29: 824-926.

Researcher : Chen H

Project Title:	Modification of cells for isolation and characterization of SARS CoV from animal sources
Investigator(s):	Chen H
Department:	Microbiology
Source(s) of Funding:	Seed Funding for New Staff
Start Date:	07/2004

Project Title:	Biological function/relevance for the 29 nucleotides insertion in the genome of animal SARS like CoV
Investigator(s):	Chen H, Guan Y
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Project Title:	Antiviral drug resistance in H5N1 virus
Investigator(s):	Chen H, Guan Y
Department:	Microbiology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2007

Project Title:	Molecular basis for the regulation of influenza virus by nuclear factor NF90
Investigator(s):	Chen H
Department:	Microbiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2011

Project Title:	Biological functiuons of of the Epstein-Barr V irus-encoded BARTs in nasopharyngeal carcinoma
Investigator(s):	Chen H
Department:	Microbiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2012

List of Research Outputs

Chen H., From SARS to bird flu-understanding the natural reservoir and mediator of wildlife borne diseases, Workshop on Wildlife-Borne Diseases Control and Management in Asia-Pacific Region, Beijing, China. 2011.

Chen H., The roles of viral determinants and host factor regulation in influenza A virus pathogenesis, Recent Advance in Pathogenic Human Viruses, The American Society for Biochemical and Molecular Biology (ASBMB) special symposium, Guangzhou, China. 2011.

Chen Y., Zheng Q., Zeng F., Lau S.Y., Wu W.L., Huang S., Zhang J., Chen H. and Xia N., Serological survey of antibodies to influenza A viruses in a group of people without a history of influenza vaccination, Clinical Microbiology and Infection. 2011, 17: 1347-9.

Huang K., Zhu H., Fan X., Wang J., Cheung C.L., Duan L., Hong W., Liu Y., Li L., Smith D.K., Chen H., Webster R.G., Webby R.J., Peiris J.S.M. and Guan Y., Establishment and Lineage Replacement of H6 Influenza Viruses in Domestic Ducks in Southern China, Journal of Virology. 2012, 86: 6075-6083.

Lai A.C.K., Wu W.L., Lau S.Y., Guan Y. and Chen H., Two-dimension antigenic dendrogram and phylogenetic tree of avian influenza virus H5N1, FEMS Immunol Med Microbiol. 2011, 64: 205-11.

Tsao G.S.W., Tsang C.M., Pang P.S., Zhang G., Chen H. and Lo K.W., The biology of EBV infection in human epithelial cells, Seminar in Cancer Biology. 2012, 22: 137-143.

Tse H., To K.K.W., Wen X., Chen H., Chan K.H., Tsoi H.W., Li I.W.S. and Yuen K.Y., Clinical and virological factors associated with viremia in pandemic influenza A/H1N1/2009 virus infection, PLoS One. 2011, 6: e22534.

Tse H., Kao R.Y.T., Wu W.L., Lim W.W., Chen H., Yeung M.Y., Woo P.C.Y., Sze K.H. and Yuen K.Y., Structural basis and sequence co-evolution analysis of the hemagglutinin protein of the pandemic influenza A/H1N1 (2009) virus, Experimental Biology and Medicine. 2011, 236: 915-25.

Wu W.L., Lau S.Y., Chen Y., Wang G., Mok B.W.Y., Wen X., Wang P., Song W., Lin T., Chan K.H., Yuen K.Y. and Chen H., 2008-2009 H1N1 influenza virus exhibits reduced susceptibility to antibody inhibition: implications for the prevalence of oseltamivir resistant variant viruses, Antiviral Research. . 2011, 93: 144-53.

Zhou F., Wang G., Buchy P., Cai Z., Chen H., Chen Z., Cheng G., Wan X.F., Deubel V. and Zhou P., A triclade DNA vaccine designed on the basis of a comprehensive serologic study elicits neutralizing antibody responses against all clades and subclades of highly pathogenic avian influenza H5N1 viruses., J Virol.. 2012, 86(12): 6970-8.

Zhu H., ZHou B., Fan X., Lam T.T.Y., Wang J., Chen A., Chen X., Chen H., Webster R.G., Webby R., Peiris J.S.M., Smith D.K. and Guan Y., Novel Reassortment of Eurasian Avian-Like and Pandemic/2009 Influenza Viruses in Swine: Infectious Potential for Humans, Journal of Virology. 2011, 85: 10432-10439.

Zhu H., Li L., Zeng Y., Zhou J., Zheng Z., Chen R., Zheng R., Duan L., Yip C.H., Huang K., Lam T.Y., Wang J., Chen H., Webster R.G., Webby R., Peiris J.S.M., Smith D.K. and Guan Y., Pandemic H1N1/2009 virus in swine: prevalence and genesis of reassortants with the potential to infect humans., 4th International Influenza Conference: Influenza2011 Zoonotic Influenza and Human Health. 2011.

Zhu H., Li L., Zeng Y., Zhou J., Zheng Z., Chen R., Zheng R., Duan L., Yip C.H., Huang K., Lam T.Y., Wang J., Chen H., Webster R.G., Webby R., Peiris J.S.M., Smith D.K. and Guan Y., Pandemic H1N1/2009 virus in swine: prevalence and genesis of reassortants with the potential to infect humans., Influenza 2011: Zoonotic Influenza and Human Health. 2011.

Researcher : Chen JHK

Project Title:	Molecular epidemiology study of HIV-1 among the men who have sex with men (MSM) population in Hong Kong
Investigator(s):	Chen JHK, Yam WC
Department:	Microbiology
Source(s) of Funding:	Council for the AIDS Trust Fund - General Award
Start Date:	04/2009

Researcher : Chen M

Project Title:	Immunogenicity and Cross-Protective Effect of Novel human T cell Epitopes in H5N1 influenza virus nucleoprotein
Investigator(s):	Chen M, Zheng B
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	10/2010

Project Title:	European Biotechnology Congress 2011 Immunogenecity and Protective Efficiency of a Novel CTL Epitope in Avian H5N1 Nucleoprotein
Investigator(s):	Chen M
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2011
Completion Date:	10/2011

Researcher : Chen Z

Project Title:	A novel model for the study of lung pathogenesis of SARS
Investigator(s):	Chen Z
Department:	Medical Faculty
Source(s) of Funding:	National Institutes of Health, US Department of Health and Human Services - General Award
Start Date:	08/2007

Project Title:	Understanding the Ongoing HIV Epidemic in Yunnan China
Investigator(s):	Chen Z
Department:	Medical Faculty
Source(s) of Funding:	China AIDS Initiative - General Award
Start Date:	05/2008

Project Title:	Preventing HIV-1 infection using a novel vaccine immunogen
Investigator(s):	Chen Z
Department:	Medical Faculty
Source(s) of Funding:	Global Health Grants
Start Date:	10/2008

Project Title:	Role of the PD-1/PD-L pathway in HIV-1 vaccine design
Investigator(s):	Chen Z
Department:	Medical Faculty
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2009

Project Title:	Characterization of novel anti-HIV/TB natural product analogues
Investigator(s):	Chen Z
Department:	Medical Faculty
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	03/2010

Project Title:	Investigation of HIV-1 new outbreaks in Fujian, China
Investigator(s):	Chen Z
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	10/2010
Completion Date:	09/2012

Project Title:	Blocking HIV infection by gene-encoding neutralizing antibodies
Investigator(s):	Chen Z
Department:	Microbiology
Source(s) of Funding:	Travel Grants for NSFC/RGC JRS
Start Date:	12/2010

Project Title:	Establishment of a rapid, high-throughput, cost-effective HIV-1 drug resistance testing system
Investigator(s):	Chen Z
Department:	Microbiology
Source(s) of Funding:	Council for the AIDS Trust Fund - General Award
Start Date:	05/2011

Project Title:	A Novel Vaccine for Mesothelioma Immunotherapy and Prevention;
Investigator(s):	Chen Z
Department:	Microbiology
Source(s) of Funding:	Pneumoconiosis Compensation Fund Board - General Award
Start Date:	07/2011

Project Title:	A promising mucosal prime and intramuscular boost AIDS vaccine regimen
Investigator(s):	Chen Z
Department:	Microbiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2011

Project Title:	AIDS Vaccine 2011 A Novel Vaccine Design for Inducing Robust HIV-1 Specific Immunity
Investigator(s):	Chen Z
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2011

Project Title:	A Novel Vaccine for Tuberculosis Prevention
Investigator(s):	Chen Z, Yam WC
Department:	Microbiology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	11/2011

Project Title:	Blocking HIV infection by gene-encoding neutralizing antibodies
Investigator(s):	Chen Z, Liu L
Department:	Microbiology
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2012

List of Research Outputs

Chen J.H., Wong K.H., Chan K.C., To S.W., Chen Z. and Yam W.C., Phylodynamics of HIV-1 subtype B among the men-having-sex-with-men (MSM) population in Hong Kong, PLoS One.. 2011, 6(9): e25286.

Kang Y., Wu Z., Lau T., Lu X., Liu L., Cheung K.L.A., Tan Z., Ng J., Liang J., Wang H., Li S., Zheng B., Li B., Chen L. and Chen Z., CCR5 Antagonist TD-0680 Uses a Novel Mechanism for Enhanced Potency against HIV-1 Entry, Cell-mediated Infection, and a Resistant Variant, JBC. JBC, 2012, 287: 16499.

Liu Z., Liu L., Chen Z., Xu M., Zhang T., Jiao Y., Sheng B., Chen D. and Wu H., Prevalence of GB virus type C viraemia in MSM with or without HIV-1 infection in Beijing, China, Epidemiol. Infect.. 2012, 26: 1-11.

Lu X., Liu L., Zhang X., Lau T.C., Tsui S.K., Kang Y., Zheng P., Zheng B., Liu G. and Chen Z., F18, a novel small molecule NNRTI, inhibits HIV-1 replication using distinct binding motifs as demonstrated by resistance selection and docking analysis, Antimicrob Agents Chemother. 2012, Jan: 56(1): 341-51.

Qiu M., Wang Q., Chu Y., Yuan Z., Song H.Y., Chen Z. and Wu Z., Lignosulfonic acid shows potent antiretroviral activity - potential as a microbicide candidate for the prevention of HIV-1 sexual transmission, PLoS One. 2012, 7(4): e35906.

Yao X., Wang H., Yan P., Lu Y., Lin H., Chen L., Ng J., Liu L. and Chen Z., Rising epidemic of HIV-1 infections among general populations in Fujian, China., JAIDS. JAIDS, 2012, 60: 328.

Zhang Q., Zhang X., Wu H., Seto D., Zhang H., Chen Z., Wan C.S. and Zheng B., Parental LTRs Are Important in a Construct of a Stable and Efficient Replication-Competent Infectious Molecular Clone of HIV-1 CRF08_BC, PLoS ONE. 2012, 7(2): e31233.

Zhou F., Wang G., Buchy P., Cai Z., Chen H., Chen Z., Cheng G., Wan X.F., Deubel V. and Zhou P., A triclade DNA vaccine designed on the basis of a comprehensive serologic study elicits neutralizing antibody responses against all clades and subclades of highly pathogenic avian influenza H5N1 viruses., J Virol.. 2012, 86(12): 6970-8.

Researcher : Cheng VCC

List of Research Outputs

Chan J.F.W., Lau S.K.P., Curreem S.O.T., To K.K.W., Leung S.S.M., Cheng V.C.C., Yuen K.Y. and Woo P.C.Y., First report of spontaneous intrapartum Atopobium vaginae bacteremia, Journal of Clinical Microbiology. 2012, 50: 2525-2528.

Cheng V.C.C., Yam W.C., Yau M.C.Y., Siu G.K.H., Wong S.C.Y., Chan J.F.W., To K.K.W., Tse H., Hung I.F.N., Tai J.W.M., Ho P.L. and Yuen K.Y., Epidemiology Of Klebsiella Oxytoca-associated Diarrhea Detected By Simmons Citrate Agar Supplemented With Inositol, Tryptophan, And Bile Salts., J Clin Microbiol. 2012, 50(5):1571-9.

Cheng V.C.C., Yam W.C., Tsang L.L., Yau M.C.Y., Siu G.K.H., Wong S.C.Y., Chan J.F.W., To K.K.W., Tse H., Hung I.F.N., Tai J.W.M., Ho P.L. and Yuen K.Y., Epidemiology of Klebsiella oxytoca-associated diarrhea detected by Simmons citrate agar supplemented with inositol, tryptophan, and bile salts, Journal of Clinical Microbiology. 2012, 50: 1571-9.

Ho P.L., Lai E.L.Y., Chow K.H. and Cheng V.C.C., Effect of applying the new CLSI imipenem susceptibility breakpoints for Enterobacteriaceae in Hong Kong, The Journal of antimicrobial chemotherapy. England, London, New York, Academic Press., 2011, 66(11): 2671-2673.

Ho P.L., Chow K.H., Lai E.L.Y., Lau H.Y. and Cheng V.C.C., Extended-spectrum-β-lactamase-positive Escherichia coli mainly adds to, rather than replaces, extended-spectrum-β-lactamase-negative E. coli in causing bacteraemia in Hong Kong, 2000-10 , Journal of Antimicrobial Chemotherapy. England, London, New York, Academic Press, 2012, 67(3): 778-80.

Singh G.H., Ip A.H., So J.C.C., Cheng V.C.C., Wong C.S., Yuen K.Y. and Kwong Y.L., Disseminated cryptococcosis mimicking a lymphoma, Eur J Haematol. 2012, 88(3): 275-6.

Researcher : Cheung CY

Project Title:	Mechanism of action for the regulation of COX-2 dependent genes in human macrophages after infection with low and high pathogenic coronavirus and influenza viruses
Investigator(s):	Cheung CY, Lee MY
Department:	Microbiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2010

Project Title:	62nd Annual Conference of the Canadian Society of Microbiologists Highly Pathogenic H5N1 Virus Causes Significant Perturbations in Host Proteome Very Early in Infected Primary Human Monocyte Derived Macrophages
Investigator(s):	Cheung CY
Department:	School of Public Health
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2012

List of Research Outputs

Hui P.Y., Lee M.Y., Cheung C.Y., Mao H., Lai K.W., Chan W.Y., Chan M.C.W., Tu W., Guan Y., Lau Y.L. and Peiris J.S.M., H5N1 influenza virus-induced mediators upregulate RIG-I in uninfected cells by paracrine effects contributing to amplified cytokine cascades, The Journal of Infectious Diseases. 2011, 204(12): 1866-1878.

Jaume M.D.A., Yip M.S., Cheung C.Y., Leung H.L., Li P.H., Kien F.S., Dutry I.C.A., Callendret B., Escriou N., Altmeyer R.M., Nal-Rogier B.T.M., Daeron M., Bruzzone R. and Peiris J.S.M., Anti-Severe Acute Respiratory Syndrome Coronavirus Spike Antibodies Trigger Infection of Human Immune Cells via a pH- and Cysteine Protease-Independent FcgR Pathway, Journal of Virology. 2011, 85.

Jaume M.D.A., Yip M.S., Cheung C.Y., Kien F.S., Li P.H., Dutry I.C.A., Bruzzone R., Peiris J.S.M., Nal-Rogier B.T.M. and Altmeyer R.M., Sars Cov Subunit Vaccine: Antibody-mediated Neutralisation And Enhancement., In: Jaume M, Yip MS, Kam YW, Cheung CY, Kien F, Roberts A, Li PH, Dutry I, Escriou N, Daeron M, Bruzzone R, Subbarao K, Peiris JS, Nal B, Altmeyer R, Hong Kong Med J.. Hong Kong, 2012, 18: Suppl 2:31-6.

Yip M.S., Cheung C.Y., Li P.H., Bruzzone R., Peiris J.S.M. and Jaume M.D.A., Investigation of Antibody-Dependent Enhancement (ADE) of SARS Coronavirus Infection and Its Role in Pathogenesis of SARS (RFCID grant 09080872), Health Research Symposium 2010: “Improving health and recognising excellence”. Food and Health Bureau, the Government of the Hong Kong Special Administrative Region. 2011.

Researcher : Cheung KW

List of Research Outputs

Lee M.Y., Gai W., Cheung K.W. and Peiris J.S.M., Antiviral activity of a selective COX-2 inhibitor on H5N1 infection in vitro., Antiviral Research. 2011, 91(3): 330-4.

Researcher : Cheung PHP

List of Research Outputs

Yen H., Liang C.-.H., Wu C.-.Y., Forrest H., Ferguson A., Choy K.T., Jones J., Wong D.D.Y., Cheung P.H.P., Hsu C.-.H., Li O.T.W., Yuen K.M., Chan W.Y., Poon L.L.M., Chan M.C.W., Nicholls J.M., Krauss S., Wong C.-.H., Guan Y., Webster R.G., Webby R. and Peiris J.S.M., Hemagglutinin-neuraminidase balance confers respiratory-droplet transmissibility of the pandemic H1N1 influenza virus in ferrets, Proceedings of National Academic Science (USA). 2011, 108: 14264-14269.

Researcher : Choi KY

List of Research Outputs

Lau S.K.P., Woo P.C.Y., Yip C.Y., Choi K.Y., Wu Y., Bai R., Fan Y.Y., Lai K.Y., Chan K.H. and Yuen K.Y., Identification of a novel feline picornavirus from the domestic cat, Journal of Virology . 2011, 86: 395-405.

Tse H., Lau S.K.P., Chan W.M., Choi K.Y., Woo P.C.Y. and Yuen K.Y., Complete genome sequences of novel canine noroviruses in Hong Kong, Journal of Virology. 2012, 86: 9531-9532.

Woo P.C.Y., Lau S.K.P., Wong B.H.L., Fan Y.Y., Wong Y.P., Zhang J., Wu Y., Choi K.Y., Li K.S.M., Hui J., Wang M., Zheng B., Chan K.H. and Yuen K.Y., Feline morbillivirus, a previously undescribed paramyxovirus associated with tubulointerstitial nephritis in domestic cats, Proceedings of the National Academy of Sciences of the USA. 2012, 109: 5435-5440.

Woo P.C.Y., Lau S.K.P., Choi K.Y., Huang Y., Teng L.L., Tsoi H.W., Tse H., Yeung M.L., Chan K.H., Jin D. and Yuen K.Y., Natural occurrence and characterization of two IRES elements in a novel virus, canine picodicistrovirus, in the picornavirus-like superfamily, Journal of Virology. 2011, 86: 2797-2808.

Researcher : Chong TK

List of Research Outputs

Woo P.C.Y., Lau S.K.P., Liu B., Cai J.J., Chong T.K., Tse H., Kao R.Y.T., Chan C.M., Chow W.N. and Yuen K.Y., Draft genome sequence of Penicillium marneffei strain PM1, Eukaryotic Cell. 2011, 10: 1740-1741.

Researcher : Chow KH

List of Research Outputs

Chiu S.S.S., Lau Y.L., Ho P.L., Ang L., Chow K.H. and Chan M.Y., Changes in nasopharyngeal carriage and serotype distribution of antibiotic-resistant Streptococcus pneumonias before and after the introduction of 7-valent pneumococcal conjugate vaccine in Hong Kong, Diagnostic Microbiology and Infectious Disease. 2011, 71(4).

Ho P.L., Lo W.U., Yeung M.K., Li Z., Chan J., Yam W.C., Tong A.H., Bao J.Y., Lin C.H., Chiu S.S.S., Lok S. and Chow K.H., Dissemination of pHK01-like incompatibility group IncFII plasmids encoding CTX-M-14 in Escherichia coli from human and animal sources., Veterinary Microbiology . 2012.

Ho P.L., Lai E.L.Y., Chow K.H. and Cheng V.C.C., Effect of applying the new CLSI imipenem susceptibility breakpoints for Enterobacteriaceae in Hong Kong, The Journal of antimicrobial chemotherapy. England, London, New York, Academic Press., 2011, 66(11): 2671-2673.

Ho P.L., Lo W.U., Lai E.L.Y., Chow K.H. and Yam W.C., Escherichia coli O25b-ST131 is an important cause of antimicrobial-resistant infections in women with uncomplicated cystitis, Journal of Antimicrobial Chemotherapy. 2012.

Ho P.L., Chow K.H., Lai E.L.Y., Lau H.Y. and Cheng V.C.C., Extended-spectrum-β-lactamase-positive Escherichia coli mainly adds to, rather than replaces, extended-spectrum-β-lactamase-negative E. coli in causing bacteraemia in Hong Kong, 2000-10 , Journal of Antimicrobial Chemotherapy. England, London, New York, Academic Press, 2012, 67(3): 778-80.

Ho P.L., Chiu S.S.S., Chan M.Y., Gan Y., Chow K.H., Lai E.L. and Lau Y.L., Molecular epidemiology and nasal carriage of Staphylococcus aureus and methicillin-resistant S. aureus among young children attending day care centers and kindergartens in Hong Kong, Journal of Infection . 2012, 64(5).

Ho P.L., Yeung M.K., Lo W.U., Tse H., Li Z., Lai E.L.Y., Chow K.H., To K.K.W. and Yam W.C., Predominance of pHK01-like incompatibility group FII plasmids encoding CTX-M-14 among extended-spectrum beta-lactamase-producing Escherichia coli in Hong Kong, 1996-2008, Diagnostic Microbiology and Infectious Diseases. 2012, 73: 182-186.

Wu Y., Mao H., Ling M.T., Chow K.H., Ho P.L., Tu W. and Lau Y.L., Successive influenza virus infection and Streptococcus pneumoniae stimulation alter human dendritic cell function., BMC Infect Dis. 2011, 20;11:201.

Researcher : Chow WN

List of Research Outputs

Woo P.C.Y., Lau S.K.P., Liu B., Cai J.J., Chong T.K., Tse H., Kao R.Y.T., Chan C.M., Chow W.N. and Yuen K.Y., Draft genome sequence of Penicillium marneffei strain PM1, Eukaryotic Cell. 2011, 10: 1740-1741.

Researcher : Choy KT

List of Research Outputs

Yen H., Liang C.-.H., Wu C.-.Y., Forrest H., Ferguson A., Choy K.T., Jones J., Wong D.D.Y., Cheung P.H.P., Hsu C.-.H., Li O.T.W., Yuen K.M., Chan W.Y., Poon L.L.M., Chan M.C.W., Nicholls J.M., Krauss S., Wong C.-.H., Guan Y., Webster R.G., Webby R. and Peiris J.S.M., Hemagglutinin-neuraminidase balance confers respiratory-droplet transmissibility of the pandemic H1N1 influenza virus in ferrets, Proceedings of National Academic Science (USA). 2011, 108: 14264-14269.

Researcher : Chu KW

List of Research Outputs

Wu J.T.K., Leung S.M., Ma S.K., Lee C.K., Chu K.W., Ho P.L., Hung I.F.N., Ho L.M., Lin C.K., Tsang T., Lo S.V., Lau Y.L., Leung G.M., Cowling B.J. and Peiris J.S.M., Characterizing the transmission dynamics and severity of the 2009 influenza pandemic in Hong Kong (abstract and poster presentation), Hong Kong College of Community Medicine Annual Scientific Meeting on 27 November 2011 in Hong Kong. Hong Kong, Hong Kong College of Community Medicine, 2011.

Wu J.T.K., Ho W.K., Ma S.K., Lee C.K., Chu K.W., Ho P.L., Hung I.F.N., Ho L.M., Lin C.K., Tsang T.H.F., Lo S.V., Lau Y.L., Leung G.M., Cowling B.J. and Peiris J.S.M., Estimating infection attack rates and severity in real time during an influenza pandemic: analysis of serial cross-sectional serologic surveillance data, PLoS Medicine. 2011, 8(10): e1001103.

Researcher : Curreem SOT

List of Research Outputs

Chan J.F.W., Lau S.K.P., Curreem S.O.T., To K.K.W., Leung S.S.M., Cheng V.C.C., Yuen K.Y. and Woo P.C.Y., First report of spontaneous intrapartum Atopobium vaginae bacteremia, Journal of Clinical Microbiology. 2012, 50: 2525-2528.

Curreem S.O.T., Watt R.M., Lau S.K.P. and Woo P.C.Y., Two-dimensional gel electrophoresis in bacterial proteomics, Protein & Cell. 2012, 3: 346-363.

Lau S.K.P., Curreem S.O.T., Ngan H.Y., Yeung C.K., Yuen K.Y. and Woo P.C.Y., First report of disseminated Mycobacterium skin infections in two liver transplant recipients and rapid diagnosis by hsp65 gene sequencing, Journal of Clinical Microbiology. 2011, 49: 3733-3737.

Lau S.K.P., Tang B.S.F., Curreem S.O.T., Chan T.M., Martelli P., Tse C.W.S., Wu A.K.L., Yuen K.Y. and Woo P.C.Y., Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry for Rapid Identification of Burkholderia pseudomallei: Importance of Expanding Databases with Pathogens Endemic to Different Localities., Journal of Clinical Microbiology. 2012, 50: 3142-3.

Wong M.Y., Lau S.K.P., Tang S.C.W., Curreem S.O.T., Woo P.C.Y. and Yuen K.Y., First Report of Peritoneal Dialysis-Related Peritonitis Caused by Citrobacter amalonaticus, Peritoneal Dialysis International. 2012, 32: 224-225.

Researcher : Duan L

List of Research Outputs

Zhu H., Li L., Zeng Y., Zhou J., Zheng Z., Chen R., Zheng R., Duan L., Yip C.H., Huang K., Lam T.Y., Wang J., Chen H., Webster R.G., Webby R., Peiris J.S.M., Smith D.K. and Guan Y., Pandemic H1N1/2009 virus in swine: prevalence and genesis of reassortants with the potential to infect humans., 4th International Influenza Conference: Influenza2011 Zoonotic Influenza and Human Health. 2011.

Researcher : Fan YY

List of Research Outputs

Lau S.K.P., Fan Y.Y., Lo H.W., Ng R.H.Y., Wong S.S.Y., Li W.S., Wu A.K.L., Ng K.H.L., Tseung S., Lee R.A., Fung K.S.C., Que T.L., Yuen K.Y. and Woo P.C.Y., High mortality associated with Catabacter hongkongensis bacteremia, Journal of Clinical Microbiology. 2012, 50: 2239-2243.

Lau S.K.P., Woo P.C.Y., Yeung C., Teng L.L., Wu Y., Bai R., Fan Y.Y., Chan K.H. and Yuen K.Y., Identification and characterization of bocaviruses in cats and dogs revealed a novel feline bocavirus and a novel genetic group of canine bocavirus, Journal of General Virology. 2012, 93: 1573-1582.

Lau S.K.P., Woo P.C.Y., Yip C.Y., Choi K.Y., Wu Y., Bai R., Fan Y.Y., Lai K.Y., Chan K.H. and Yuen K.Y., Identification of a novel feline picornavirus from the domestic cat, Journal of Virology . 2011, 86: 395-405.

Lau S.K.P., Woo P.C.Y., Yip C.Y., Fan Y.Y., Huang Y., Wang M., Guo R., Lam S.F., Tsang K.L., Lai K.Y., Chan K.H., Che X.Y., Zheng B. and Yuen K.Y., Isolation and characterization of a novel Betacoronavirus subgroup A coronavirus, rabbit coronavirus HKU14, from domestic rabbits, Journal of Virology. 2012, 86: 5481-5496.

Lau S.K.P., Fan Y.Y., Wong G.K.M., Teng L.L., Sze K.H., Tse H., Yuen K.Y. and Woo P.C.Y., Transport genes and chemotaxis in Laribacter hongkongensis: a genome-wide analysis, Cell and Bioscience. 2011, 1: 28.

Tse H., Chan W.M., Tsoi H.W., Fan Y.Y., Lau C.Y., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Rediscovery and genomic characterization of bovine astroviruses, Journal of General Virology. 2011, 2011, 92: 1888-1898.

Woo P.C.Y., Lau S.K.P., Wong B.H.L., Fan Y.Y., Wong Y.P., Zhang J., Wu Y., Choi K.Y., Li K.S.M., Hui J., Wang M., Zheng B., Chan K.H. and Yuen K.Y., Feline morbillivirus, a previously undescribed paramyxovirus associated with tubulointerstitial nephritis in domestic cats, Proceedings of the National Academy of Sciences of the USA. 2012, 109: 5435-5440.

Researcher : Gai W

List of Research Outputs

Lee M.Y., Gai W., Cheung K.W. and Peiris J.S.M., Antiviral activity of a selective COX-2 inhibitor on H5N1 infection in vitro., Antiviral Research. 2011, 91(3): 330-4.

Researcher : Gan YT

List of Research Outputs

Ho P.L. and Gan Y.T., The relationship between methicillin-resistant Staphylococcus aureus lineages, environmental contamination and biological fitness, Pokfulam Road, Hong Kong, University of Hong Kong, 2011.

Researcher : Guan Y

Project Title:	Vaccines for the control of H5N1 and other avian influenza viruses
Investigator(s):	Guan Y
Department:	Microbiology
Source(s) of Funding:	The University of Hong Kong Foundation Seed Grant
Start Date:	04/2002

Project Title:	Searching for the precursor of SARS-Cov in Southern China
Investigator(s):	Guan Y
Department:	Microbiology
Source(s) of Funding:	VCO SARS Research Fund
Start Date:	07/2003

Project Title:	State Key Laboratory of Emerging Infectious Diseases
Investigator(s):	Guan Y
Department:	Microbiology
Source(s) of Funding:	Matching Fund for State Key Laboratory (SKL)
Start Date:	02/2009

Project Title:	Long-term surveillance for bat-borne viruses: An insight into viral ecology, evolutionary dynamics, and the source of zoonoses
Investigator(s):	Guan Y, Dhanasekaran V, Lai ACK, Zhu H
Department:	Microbiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2010

List of Research Outputs

Ducatez M.F., Cai Z., Peiris J.S.M., Guan Y., Ye Z., Wan X.F. and Webby R.J., Extent of antigenic cross-reactivity among highly pathogenic H5N1 influrnza viruses, Journal of Clinical Microbiology. 2011, 49(10): 3531-6.

Hui P.Y., Lee M.Y., Cheung C.Y., Mao H., Lai K.W., Chan W.Y., Chan M.C.W., Tu W., Guan Y., Lau Y.L. and Peiris J.S.M., H5N1 influenza virus-induced mediators upregulate RIG-I in uninfected cells by paracrine effects contributing to amplified cytokine cascades, The Journal of Infectious Diseases. 2011, 204(12): 1866-1878.

Lam T.Y., Zhu H., Wang J., Smith D.K., Holmes E.C., Webster R.G., Webby R., Peiris J.S.M. and Guan Y., Reassortment Events Among Swine Influenza A Viruses in China: Implications for the Origin of the 2009 Influenza Pandemic, J Virol. 2011, 85(19): 10279-85.

Lessler J., Cummings D.A.T., Read J.M., Wang S., Zhu H., Smith G.J., Guan Y., Jiang C. and Riley S., Location-specific patterns of exposure to recent pre-pandemic strains of influenza A in southern China, Nat Commun. 2011, 2:423: doi:10.1038/ncomms1432.

Liu Y., Cao M., Zhu H. and Guan Y., Detection and Phylogenetic Analysis of Coronavirus from Ducks and Chickens in Southern China., 49th Infectious Diseases Society of America (IDSA) Annual Meeting. 2011.

Yen H., Liang C.-.H., Wu C.-.Y., Forrest H., Ferguson A., Choy K.T., Jones J., Wong D.D.Y., Cheung P.H.P., Hsu C.-.H., Li O.T.W., Yuen K.M., Chan W.Y., Poon L.L.M., Chan M.C.W., Nicholls J.M., Krauss S., Wong C.-.H., Guan Y., Webster R.G., Webby R. and Peiris J.S.M., Hemagglutinin-neuraminidase balance confers respiratory-droplet transmissibility of the pandemic H1N1 influenza virus in ferrets, Proceedings of National Academic Science (USA). 2011, 108: 14264-14269.

Zhu H., Li L., Zeng Y., Zhou J., Zheng Z., Chen R., Zheng R., Duan L., Yip C.H., Huang K., Lam T.Y., Wang J., Chen H., Webster R.G., Webby R., Peiris J.S.M., Smith D.K. and Guan Y., Pandemic H1N1/2009 virus in swine: prevalence and genesis of reassortants with the potential to infect humans., 4th International Influenza Conference: Influenza2011 Zoonotic Influenza and Human Health. 2011.

Researcher : Ho CC

List of Research Outputs

Ho C.C., Wu A.K.L., Tse C.W.S., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Automated pangenomic analysis in target selection for PCR detection and identification of bacteria by use of ssGeneFinder Webserver and its application to Salmonella enterica serovar Typhi, Journal of Clinical Microbiology. 2012, 50: 1905-1911.

Ho C.C., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Rapid identification and validation of specific molecular targets for detection of Escherichia coli O104:H4 outbreak strain using high-throughput sequencing data from nine genomes, Journal of Clinical Microbiology. 2011, 49: 3714-3716.

Researcher : Ho PL

Project Title:	A phenotypic and genotypic analysis of vancomycin tolerance in Streptococcus pnemoniae
Investigator(s):	Ho PL, Yuen KY, Que TL
Department:	Microbiology
Source(s) of Funding:	Low Budget High Impact Programme
Start Date:	11/2000

Project Title:	Molecular epidemiology of fluoroquinolone-resistant streptococcus pneumoniae in Hong kong and Canada
Investigator(s):	Ho PL
Department:	Microbiology
Source(s) of Funding:	Low Budget High Impact Programme
Start Date:	11/2001

Project Title:	Risk factors for SARS in health care workers following incubation of SARS patients
Investigator(s):	Ho PL, Hung CT
Department:	Microbiology
Source(s) of Funding:	VCO SARS Research Fund
Start Date:	07/2003

Project Title:	Fluoroquinolone susceptibility clinical breakpoints and fluoroquinolone-resistant determining mutations among clinical strains of streptococcus pneumoniae
Investigator(s):	Ho PL, Wong SSY
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Project Title:	Evaluation of molecular tests for the rapid detection of rifampicin and isoniazid resistance in Mycobacterium tuberculosis and their impact on patient management
Investigator(s):	Ho PL, Yam WC, Leung CC, Yew WW, Mok YW, Chan KS, Tam CM
Department:	Microbiology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	04/2006

List of Research Outputs

Cheng V.C.C., Yam W.C., Yau M.C.Y., Siu G.K.H., Wong S.C.Y., Chan J.F.W., To K.K.W., Tse H., Hung I.F.N., Tai J.W.M., Ho P.L. and Yuen K.Y., Epidemiology Of Klebsiella Oxytoca-associated Diarrhea Detected By Simmons Citrate Agar Supplemented With Inositol, Tryptophan, And Bile Salts., J Clin Microbiol. 2012, 50(5):1571-9.

Cheng V.C.C., Yam W.C., Tsang L.L., Yau M.C.Y., Siu G.K.H., Wong S.C.Y., Chan J.F.W., To K.K.W., Tse H., Hung I.F.N., Tai J.W.M., Ho P.L. and Yuen K.Y., Epidemiology of Klebsiella oxytoca-associated diarrhea detected by Simmons citrate agar supplemented with inositol, tryptophan, and bile salts, Journal of Clinical Microbiology. 2012, 50: 1571-9.

Chiu S.S.S., Lau Y.L., Ho P.L., Ang L., Chow K.H. and Chan M.Y., Changes in nasopharyngeal carriage and serotype distribution of antibiotic-resistant Streptococcus pneumonias before and after the introduction of 7-valent pneumococcal conjugate vaccine in Hong Kong, Diagnostic Microbiology and Infectious Disease. 2011, 71(4).

Ho P.L., Lo W.U., Yeung M.K., Li Z., Chan J., Yam W.C., Tong A.H., Bao J.Y., Lin C.H., Chiu S.S.S., Lok S. and Chow K.H., Dissemination of pHK01-like incompatibility group IncFII plasmids encoding CTX-M-14 in Escherichia coli from human and animal sources., Veterinary Microbiology . 2012.

Ho P.L., Lai E.L.Y., Chow K.H. and Cheng V.C.C., Effect of applying the new CLSI imipenem susceptibility breakpoints for Enterobacteriaceae in Hong Kong, The Journal of antimicrobial chemotherapy. England, London, New York, Academic Press., 2011, 66(11): 2671-2673.

Ho P.L., Li Z., Lai E.L.Y., Cheng V.C. and Chiu S.S.S., Emergence of NDM-1-producing Enterobacteriaceae in China, J Antimicrob Chemother. 2012, 67(6).

Ho P.L. and Yeung M.K., Epidemiology of CTX-M type extended-spectrum beta-lactamase-producing Escherichia coli among blood culture isolates in Hong Kong, Pokfulam Road, Hong Kong, University of Hong Kong, 2011.

Ho P.L., Lo W.U., Lai E.L.Y., Chow K.H. and Yam W.C., Escherichia coli O25b-ST131 is an important cause of antimicrobial-resistant infections in women with uncomplicated cystitis, Journal of Antimicrobial Chemotherapy. 2012.

Ho P.L., Chow K.H., Lai E.L.Y., Lau H.Y. and Cheng V.C.C., Extended-spectrum-β-lactamase-positive Escherichia coli mainly adds to, rather than replaces, extended-spectrum-β-lactamase-negative E. coli in causing bacteraemia in Hong Kong, 2000-10 , Journal of Antimicrobial Chemotherapy. England, London, New York, Academic Press, 2012, 67(3): 778-80.

Ho P.L., Chiu S.S.S., Chan M.Y., Gan Y., Chow K.H., Lai E.L. and Lau Y.L., Molecular epidemiology and nasal carriage of Staphylococcus aureus and methicillin-resistant S. aureus among young children attending day care centers and kindergartens in Hong Kong, Journal of Infection . 2012, 64(5).

Ho P.L., Yeung M.K., Lo W.U., Tse H., Li Z., Lai E.L.Y., Chow K.H., To K.K.W. and Yam W.C., Predominance of pHK01-like incompatibility group FII plasmids encoding CTX-M-14 among extended-spectrum beta-lactamase-producing Escherichia coli in Hong Kong, 1996-2008, Diagnostic Microbiology and Infectious Diseases. 2012, 73: 182-186.

Ho P.L. and Leung Y.H., Risk factors for community-associated methicillin-resistant Staphylococcus aureus infection in Hong Kong, The Journal of infection. England, London, New York, Academic Press, 2012, 64(5): 494-499.

Ho P.L. and Iwao Y., The emerging ST8 methicillin-resistant Staphylococcus aureus clone in the community in Japan: associated infections, genetic diversity, and comparative genomics, Journal of infection and chemotherapy. Japan, Tokyo : New York : Published for the Society by Churchill Li, 2012, 18(2): 228-240.

Ho P.L. and Gan Y.T., The relationship between methicillin-resistant Staphylococcus aureus lineages, environmental contamination and biological fitness, Pokfulam Road, Hong Kong, University of Hong Kong, 2011.

Ho P.L. and Siu T.P., Vancomycin heteroresistance in blood isolates of methicillin-resistant Staphylococcus aureus, Pokfulam Road, Hong Kong, University of Hong Kong, 2011.

Lam T.H., Yuen K.Y., Ho P.L., Weng X.H., Zhang W.H., Chen S. and Yam W.C., Truncated Rv2820c enhances mycobacterial virulence ex vivo and in vivo, Microbial pathogenesis. England, London ; Orlando : Academic Press, 2012, 50 (6): 331-335.

Lo W.U. and Ho P.L., Epidemiology of CTX-M type extended-spectrum beta-lactamases in escherichia coli isolates from human and animals, (Pokfulam Road, Hong Kong, University of Hong Kong, 2011.

Ting J.Y., Ho P.L. and Wong K.Y., Bordetella bronchiseptica Pneumona in an Extremely-Low-Birth-Weigh Neonate , American Journal of Perinatology Reports. 2011, 1(2): 83-86.

Wu J.T.K., Leung S.M., Ma S.K., Lee C.K., Chu K.W., Ho P.L., Hung I.F.N., Ho L.M., Lin C.K., Tsang T., Lo S.V., Lau Y.L., Leung G.M., Cowling B.J. and Peiris J.S.M., Characterizing the transmission dynamics and severity of the 2009 influenza pandemic in Hong Kong (abstract and poster presentation), Hong Kong College of Community Medicine Annual Scientific Meeting on 27 November 2011 in Hong Kong. Hong Kong, Hong Kong College of Community Medicine, 2011.

Wu J.T.K., Ho W.K., Ma S.K., Lee C.K., Chu K.W., Ho P.L., Hung I.F.N., Ho L.M., Lin C.K., Tsang T.H.F., Lo S.V., Lau Y.L., Leung G.M., Cowling B.J. and Peiris J.S.M., Estimating infection attack rates and severity in real time during an influenza pandemic: analysis of serial cross-sectional serologic surveillance data, PLoS Medicine. 2011, 8(10): e1001103.

Wu J.T.K., Ho A.L.Y., Ma E., Lee C.K., Chu D., Ho P.L., Hung I.F.N., Lin C.K., Tsang T., Lo S.V., Lau Y.L., Leung G.M., Cowling B.J. and Peiris J.S.M., Estimating infection attack rates and severity in real-time during an influenza pandemic (abstract), 4th ESWI Influenza Conference on 11-14 September 2011 in Malta. Malta, European Scientific Working Group on Influenza, 2011, B619P.

Wu Y., Mao H., Ling M.T., Chow K.H., Ho P.L., Tu W. and Lau Y.L., Successive influenza virus infection and Streptococcus pneumoniae stimulation alter human dendritic cell function., BMC Infect Dis. 2011, 20;11:201.

Researcher : Ho PL

List of Research Outputs

Ho P.L., Li Z., Lai E.L.Y., Cheng V.C. and Chiu S.S.S., Emergence of NDM-1-producing Enterobacteriaceae in China, J Antimicrob Chemother. 2012, 67(6).

Ho P.L. and Siu T.P., Vancomycin heteroresistance in blood isolates of methicillin-resistant Staphylococcus aureus, Pokfulam Road, Hong Kong, University of Hong Kong, 2011.

Lo W.U. and Ho P.L., Epidemiology of CTX-M type extended-spectrum beta-lactamases in escherichia coli isolates from human and animals, (Pokfulam Road, Hong Kong, University of Hong Kong, 2011.

Ting J.Y., Ho P.L. and Wong K.Y., Bordetella bronchiseptica Pneumona in an Extremely-Low-Birth-Weigh Neonate , American Journal of Perinatology Reports. 2011, 1(2): 83-86.

Researcher : Huang K

List of Research Outputs

Zhu H., Li L., Zeng Y., Zhou J., Zheng Z., Chen R., Zheng R., Duan L., Yip C.H., Huang K., Lam T.Y., Wang J., Chen H., Webster R.G., Webby R., Peiris J.S.M., Smith D.K. and Guan Y., Pandemic H1N1/2009 virus in swine: prevalence and genesis of reassortants with the potential to infect humans., 4th International Influenza Conference: Influenza2011 Zoonotic Influenza and Human Health. 2011.

Researcher : Huang Y

List of Research Outputs

Lau S.K.P., Woo P.C.Y., Yip C.Y., Fan Y.Y., Huang Y., Wang M., Guo R., Lam S.F., Tsang K.L., Lai K.Y., Chan K.H., Che X.Y., Zheng B. and Yuen K.Y., Isolation and characterization of a novel Betacoronavirus subgroup A coronavirus, rabbit coronavirus HKU14, from domestic rabbits, Journal of Virology. 2012, 86: 5481-5496.

Woo P.C.Y., Lau S.K.P., Choi K.Y., Huang Y., Teng L.L., Tsoi H.W., Tse H., Yeung M.L., Chan K.H., Jin D. and Yuen K.Y., Natural occurrence and characterization of two IRES elements in a novel virus, canine picodicistrovirus, in the picornavirus-like superfamily, Journal of Virology. 2011, 86: 2797-2808.

Researcher : Hui PY

Project Title:	Role of retinoic acid inducible gene-1, toll-like receptor-3 and -8 in cytokine induction by influenza A H5N1 and pandemic H1N1 viruses in primary human cells
Investigator(s):	Hui PY, Peiris JSM, Cheung CY, Chan MCW, Lee MY, Chan WY
Department:	Microbiology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	11/2010

Project Title:	Role of focal adhesion kinase in cytokine production by influenza A H5N1 infection
Investigator(s):	Hui PY, Peiris JSM
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	03/2011
Completion Date:	08/2012

List of Research Outputs

Hui P.Y., Lee M.Y., Cheung C.Y., Mao H., Lai K.W., Chan W.Y., Chan M.C.W., Tu W., Guan Y., Lau Y.L. and Peiris J.S.M., H5N1 influenza virus-induced mediators upregulate RIG-I in uninfected cells by paracrine effects contributing to amplified cytokine cascades, The Journal of Infectious Diseases. 2011, 204(12): 1866-1878.

Researcher : Im SWK

Project Title:	Investigation of community exposure to a novel coronavirus associated with SARS and herd immunity developed among healthy blood donors
Investigator(s):	Im SWK, Yam WC
Department:	Microbiology
Source(s) of Funding:	VCO SARS Research Fund
Start Date:	07/2003

Researcher : Kang Y

List of Research Outputs

Kang Y., Wu Z., Lau T., Lu X., Liu L., Cheung K.L.A., Tan Z., Ng J., Liang J., Wang H., Li S., Zheng B., Li B., Chen L. and Chen Z., CCR5 Antagonist TD-0680 Uses a Novel Mechanism for Enhanced Potency against HIV-1 Entry, Cell-mediated Infection, and a Resistant Variant, JBC. JBC, 2012, 287: 16499.

Lu X., Liu L., Zhang X., Lau T.C., Tsui S.K., Kang Y., Zheng P., Zheng B., Liu G. and Chen Z., F18, a novel small molecule NNRTI, inhibits HIV-1 replication using distinct binding motifs as demonstrated by resistance selection and docking analysis, Antimicrob Agents Chemother. 2012, Jan: 56(1): 341-51.

Researcher : Kao RYT

Project Title:	Mode of action of a lead anti-influenza compound identified by chemical genetics
Investigator(s):	Kao RYT
Department:	Microbiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2006

Project Title:	Cloning and characterization of Streptococcus pneumoniae methionine aminopeptidase: a potential target for antimicrobial therapies
Investigator(s):	Kao RYT
Department:	Microbiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2007

Project Title:	Mechanism of novel antagonists of influenza A nucleoprotein trafficking: A chemical genetics approach
Investigator(s):	Kao RYT, Chen H, Yang D, Yuen KY
Department:	Microbiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2011

Project Title:	The 25th International Conference on Antiviral Research Nucleozin elicits rapid and target-specific aggregation of influenza A nucleoprotein (NP)
Investigator(s):	Kao RYT
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2012
Completion Date:	04/2012

List of Research Outputs

Kao R.Y.T. and Yuen K.Y., Faculty Outstanding Research Award, LKS Faculty of Medicine, HKU. 2011.

Li T.L., Kao R.Y.T., Cheung K.M.C., Wu S.L., Chu P.K., Luk K.D.K., Cheung K.M.C. and Yeung K.W.K., Antibacterial Properties of Novel 1D ZnO Nanowires on Medical Grade 316L Stainless Steel Surface, 9th World Biomaterials Congress, Chengdu, China. 2012.

Li T.L., Kao R.Y.T., Cheung K.M.C., Wu S.L., Chu P., Luk K.D.K. and Yeung K.W.K., Antibacterial properties of novel one-dimensional zinc oxide nanowires on medical-grade 316L stainless steel surface, 31st Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 19-20, 2011.

Tse H., Kao R.Y.T., Wu W.L., Lim W.W., Chen H., Yeung M.Y., Woo P.C.Y., Sze K.H. and Yuen K.Y., Structural basis and sequence co-evolution analysis of the hemagglutinin protein of the pandemic influenza A/H1N1 (2009) virus, Experimental Biology and Medicine. 2011, 236: 915-25.

Woo P.C.Y., Lau S.K.P., Liu B., Cai J.J., Chong T.K., Tse H., Kao R.Y.T., Chan C.M., Chow W.N. and Yuen K.Y., Draft genome sequence of Penicillium marneffei strain PM1, Eukaryotic Cell. 2011, 10: 1740-1741.

Researcher : Lai ACK

List of Research Outputs

Lai A.C.K., Wu W.L., Lau S.Y., Guan Y. and Chen H., Two-dimension antigenic dendrogram and phylogenetic tree of avian influenza virus H5N1, FEMS Immunol Med Microbiol. 2011, 64: 205-11.

Researcher : Lai ELY

List of Research Outputs

Ho P.L., Lai E.L.Y., Chow K.H. and Cheng V.C.C., Effect of applying the new CLSI imipenem susceptibility breakpoints for Enterobacteriaceae in Hong Kong, The Journal of antimicrobial chemotherapy. England, London, New York, Academic Press., 2011, 66(11): 2671-2673.

Ho P.L., Li Z., Lai E.L.Y., Cheng V.C. and Chiu S.S.S., Emergence of NDM-1-producing Enterobacteriaceae in China, J Antimicrob Chemother. 2012, 67(6).

Ho P.L., Lo W.U., Lai E.L.Y., Chow K.H. and Yam W.C., Escherichia coli O25b-ST131 is an important cause of antimicrobial-resistant infections in women with uncomplicated cystitis, Journal of Antimicrobial Chemotherapy. 2012.

Ho P.L., Chow K.H., Lai E.L.Y., Lau H.Y. and Cheng V.C.C., Extended-spectrum-β-lactamase-positive Escherichia coli mainly adds to, rather than replaces, extended-spectrum-β-lactamase-negative E. coli in causing bacteraemia in Hong Kong, 2000-10 , Journal of Antimicrobial Chemotherapy. England, London, New York, Academic Press, 2012, 67(3): 778-80.

Ho P.L., Yeung M.K., Lo W.U., Tse H., Li Z., Lai E.L.Y., Chow K.H., To K.K.W. and Yam W.C., Predominance of pHK01-like incompatibility group FII plasmids encoding CTX-M-14 among extended-spectrum beta-lactamase-producing Escherichia coli in Hong Kong, 1996-2008, Diagnostic Microbiology and Infectious Diseases. 2012, 73: 182-186.

Researcher : Lai KW

List of Research Outputs

Hui P.Y., Lee M.Y., Cheung C.Y., Mao H., Lai K.W., Chan W.Y., Chan M.C.W., Tu W., Guan Y., Lau Y.L. and Peiris J.S.M., H5N1 influenza virus-induced mediators upregulate RIG-I in uninfected cells by paracrine effects contributing to amplified cytokine cascades, The Journal of Infectious Diseases. 2011, 204(12): 1866-1878.

Researcher : Lai KY

List of Research Outputs

Lau S.K.P., Woo P.C.Y., Lai K.Y., Huang Y., Yip C.Y., Shek C.T., Lee P., Lam S.F., Chan K.H. and Yuen K.Y., Complete genome analysis of three novel picornaviruses from diverse bat species, Journal of Virology. 2011, 85: 8819-8828.

Lau S.K.P., Woo P.C.Y., Yip C.Y., Choi K.Y., Wu Y., Bai R., Fan Y.Y., Lai K.Y., Chan K.H. and Yuen K.Y., Identification of a novel feline picornavirus from the domestic cat, Journal of Virology . 2011, 86: 395-405.

Lau S.K.P., Woo P.C.Y., Yip C.Y., Fan Y.Y., Huang Y., Wang M., Guo R., Lam S.F., Tsang K.L., Lai K.Y., Chan K.H., Che X.Y., Zheng B. and Yuen K.Y., Isolation and characterization of a novel Betacoronavirus subgroup A coronavirus, rabbit coronavirus HKU14, from domestic rabbits, Journal of Virology. 2012, 86: 5481-5496.

Researcher : Lai KY

List of Research Outputs

Researcher : Lam SF

List of Research Outputs

Lau S.K.P., Woo P.C.Y., Lai K.Y., Huang Y., Yip C.Y., Shek C.T., Lee P., Lam S.F., Chan K.H. and Yuen K.Y., Complete genome analysis of three novel picornaviruses from diverse bat species, Journal of Virology. 2011, 85: 8819-8828.

Lau S.K.P., Woo P.C.Y., Yip C.Y., Fan Y.Y., Huang Y., Wang M., Guo R., Lam S.F., Tsang K.L., Lai K.Y., Chan K.H., Che X.Y., Zheng B. and Yuen K.Y., Isolation and characterization of a novel Betacoronavirus subgroup A coronavirus, rabbit coronavirus HKU14, from domestic rabbits, Journal of Virology. 2012, 86: 5481-5496.

Woo P.C.Y., Lau S.K.P., Lam S.F., Lau C.Y., Tsang K.L., Lau J.H.N., Bai R., Teng L.L., Tsang C.C.C., Wang M., Zheng B., Chan K.H. and Yuen K.Y., Discovery of seven novel mammalian and avian coronaviruses in Deltacoronavirus supports bat coronaviruses as the gene source of Alphacoronavirus and Betacoronavirus and avian coronaviruses as the gene source of Gammacoronavirus and Deltacoronavirus, Journal of Virology. 2012, 86: 3995-4008.

Woo P.C.Y., Lau S.K.P., Wong B.H.L., Wu Y., Lam S.F. and Yuen K.Y., Novel variant of Beilong paramyxovirus in rats, China, Emerging Infectious Diseases. 2012, 18: 1022-1024.

Researcher : Lam TH

List of Research Outputs

Lam T.H., Yuen K.Y., Ho P.L., Weng X.H., Zhang W.H., Chen S. and Yam W.C., Truncated Rv2820c enhances mycobacterial virulence ex vivo and in vivo, Microbial pathogenesis. England, London ; Orlando : Academic Press, 2012, 50 (6): 331-335.

Researcher : Lam TY

List of Research Outputs

Lam T.Y., Zhu H., Wang J., Smith D.K., Holmes E.C., Webster R.G., Webby R., Peiris J.S.M. and Guan Y., Reassortment Events Among Swine Influenza A Viruses in China: Implications for the Origin of the 2009 Influenza Pandemic, J Virol. 2011, 85(19): 10279-85.

Zhu H., Li L., Zeng Y., Zhou J., Zheng Z., Chen R., Zheng R., Duan L., Yip C.H., Huang K., Lam T.Y., Wang J., Chen H., Webster R.G., Webby R., Peiris J.S.M., Smith D.K. and Guan Y., Pandemic H1N1/2009 virus in swine: prevalence and genesis of reassortants with the potential to infect humans., 4th International Influenza Conference: Influenza2011 Zoonotic Influenza and Human Health. 2011.

Researcher : Lau CY

List of Research Outputs

Tse H., Chan W.M., Tsoi H.W., Fan Y.Y., Lau C.Y., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Rediscovery and genomic characterization of bovine astroviruses, Journal of General Virology. 2011, 2011, 92: 1888-1898.

Woo P.C.Y., Lau S.K.P., Lam S.F., Lau C.Y., Tsang K.L., Lau J.H.N., Bai R., Teng L.L., Tsang C.C.C., Wang M., Zheng B., Chan K.H. and Yuen K.Y., Discovery of seven novel mammalian and avian coronaviruses in Deltacoronavirus supports bat coronaviruses as the gene source of Alphacoronavirus and Betacoronavirus and avian coronaviruses as the gene source of Gammacoronavirus and Deltacoronavirus, Journal of Virology. 2012, 86: 3995-4008.

Researcher : Lau S.K.P.

Project Title:	The role of bats in the origin of severe acute respiratory syndrome coronavirus
Investigator(s):	Lau SKP, Woo PCY, Yuen KY
Department:	Microbiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2007

Project Title:	Genotyping of bat coronavirus HKU9, a novel bat coronavirus identified in Hong Kong
Investigator(s):	Lau SKP, Woo PCY, Yuen KY
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	09/2009
Completion Date:	08/2011

Project Title:	The role of a novel rhinovirus species, rhinovirus C, in respiratory illness and its molecular epidemiology
Investigator(s):	Lau SKP, Tse H, Woo PCY, Yuen KY
Department:	Microbiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2010
Completion Date:	12/2011

Project Title:	Clinical, phenotypic and molecular characterization of Catabacter hongkongensis recovered from blood cultures of patients
Investigator(s):	Lau SKP, Woo PCY, Yuen KY
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	09/2010
Completion Date:	09/2012

Project Title:	Molecular characterization of novel animal bocaviruses
Investigator(s):	Lau SKP, Woo PCY, Yuen KY
Department:	Microbiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2010

Project Title:	Genomic and serological characterization of novel animal paramyxoviruses
Investigator(s):	Lau SKP, Woo PCY, Yuen KY
Department:	Microbiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2011

Project Title:	Phenotypic and molecular characterization of a novel Streptococcus species associated with wound infection
Investigator(s):	Lau SKP, Woo PCY, Yuen KY
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2012

List of Research Outputs

Researcher : Lau SKP

Project Title:	The role of bats in the origin of severe acute respiratory syndrome coronavirus
Investigator(s):	Lau SKP, Woo PCY, Yuen KY
Department:	Microbiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2007

Project Title:	Genotyping of bat coronavirus HKU9, a novel bat coronavirus identified in Hong Kong
Investigator(s):	Lau SKP, Woo PCY, Yuen KY
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	09/2009
Completion Date:	08/2011

Project Title:	The role of a novel rhinovirus species, rhinovirus C, in respiratory illness and its molecular epidemiology
Investigator(s):	Lau SKP, Tse H, Woo PCY, Yuen KY
Department:	Microbiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2010
Completion Date:	12/2011

Project Title:	Clinical, phenotypic and molecular characterization of Catabacter hongkongensis recovered from blood cultures of patients
Investigator(s):	Lau SKP, Woo PCY, Yuen KY
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	09/2010
Completion Date:	09/2012

Project Title:	Molecular characterization of novel animal bocaviruses
Investigator(s):	Lau SKP, Woo PCY, Yuen KY
Department:	Microbiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2010

Project Title:	Genomic and serological characterization of novel animal paramyxoviruses
Investigator(s):	Lau SKP, Woo PCY, Yuen KY
Department:	Microbiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2011

Project Title:	Phenotypic and molecular characterization of a novel Streptococcus species associated with wound infection
Investigator(s):	Lau SKP, Woo PCY, Yuen KY
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2012

List of Research Outputs

Chan J.F.W., Lau S.K.P., Curreem S.O.T., To K.K.W., Leung S.S.M., Cheng V.C.C., Yuen K.Y. and Woo P.C.Y., First report of spontaneous intrapartum Atopobium vaginae bacteremia, Journal of Clinical Microbiology. 2012, 50: 2525-2528.

Chan J.F.W., Woo P.C.Y., Teng L.L., Lau S.K.P., Leung S.S.M., Tam F.C.C. and Yuen K.Y., Primary infective spondylodiscitis caused by Lactococcus garvieae and a review of human L. garvieae infections, Infection. 2011, 39: 259-264.

Curreem S.O.T., Watt R.M., Lau S.K.P. and Woo P.C.Y., Two-dimensional gel electrophoresis in bacterial proteomics, Protein & Cell. 2012, 3: 346-363.

Ho C.C., Wu A.K.L., Tse C.W.S., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Automated pangenomic analysis in target selection for PCR detection and identification of bacteria by use of ssGeneFinder Webserver and its application to Salmonella enterica serovar Typhi, Journal of Clinical Microbiology. 2012, 50: 1905-1911.

Ho C.C., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Rapid identification and validation of specific molecular targets for detection of Escherichia coli O104:H4 outbreak strain using high-throughput sequencing data from nine genomes, Journal of Clinical Microbiology. 2011, 49: 3714-3716.

Lau S.K.P., Woo P.C.Y., Lai K.Y., Huang Y., Yip C.Y., Shek C.T., Lee P., Lam S.F., Chan K.H. and Yuen K.Y., Complete genome analysis of three novel picornaviruses from diverse bat species, Journal of Virology. 2011, 85: 8819-8828.

Lau S.K.P., Curreem S.O.T., Ngan H.Y., Yeung C.K., Yuen K.Y. and Woo P.C.Y., First report of disseminated Mycobacterium skin infections in two liver transplant recipients and rapid diagnosis by hsp65 gene sequencing, Journal of Clinical Microbiology. 2011, 49: 3733-3737.

Lau S.K.P., Fan Y.Y., Lo H.W., Ng R.H.Y., Wong S.S.Y., Li W.S., Wu A.K.L., Ng K.H.L., Tseung S., Lee R.A., Fung K.S.C., Que T.L., Yuen K.Y. and Woo P.C.Y., High mortality associated with Catabacter hongkongensis bacteremia, Journal of Clinical Microbiology. 2012, 50: 2239-2243.

Lau S.K.P., Woo P.C.Y., Yeung C., Teng L.L., Wu Y., Bai R., Fan Y.Y., Chan K.H. and Yuen K.Y., Identification and characterization of bocaviruses in cats and dogs revealed a novel feline bocavirus and a novel genetic group of canine bocavirus, Journal of General Virology. 2012, 93: 1573-1582.

Lau S.K.P., Woo P.C.Y., Yip C.Y., Choi K.Y., Wu Y., Bai R., Fan Y.Y., Lai K.Y., Chan K.H. and Yuen K.Y., Identification of a novel feline picornavirus from the domestic cat, Journal of Virology . 2011, 86: 395-405.

Lau S.K.P., Woo P.C.Y., Yip C.Y., Fan Y.Y., Huang Y., Wang M., Guo R., Lam S.F., Tsang K.L., Lai K.Y., Chan K.H., Che X.Y., Zheng B. and Yuen K.Y., Isolation and characterization of a novel Betacoronavirus subgroup A coronavirus, rabbit coronavirus HKU14, from domestic rabbits, Journal of Virology. 2012, 86: 5481-5496.

Lau S.K.P., Tang B.S.F., Curreem S.O.T., Chan T.M., Martelli P., Tse C.W.S., Wu A.K.L., Yuen K.Y. and Woo P.C.Y., Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry for Rapid Identification of Burkholderia pseudomallei: Importance of Expanding Databases with Pathogens Endemic to Different Localities., Journal of Clinical Microbiology. 2012, 50: 3142-3.

Lau S.K.P., Lee P., Tsang K.L., Yip C.Y., Tse H., Lee R.A., So L.Y., Lau Y.L., Chan K.H., Woo P.C.Y. and Yuen K.Y., Molecular epidemiology of human coronavirus OC43 reveals evolution of different genotypes over time and recent emergence of a novel genotype due to natural recombination., Journal of Virology. 2011, 85: 11325-11337.

Lau S.K.P., Fan Y.Y., Wong G.K.M., Teng L.L., Sze K.H., Tse H., Yuen K.Y. and Woo P.C.Y., Transport genes and chemotaxis in Laribacter hongkongensis: a genome-wide analysis, Cell and Bioscience. 2011, 1: 28.

Tao Y., Tang K., Shi M., Conrardy C., Li K.S.M., Lau S.K.P., Anderson L.J. and Tong S., Genomic characterization of seven distinct bat coronaviruses in Kenya, Virus Research. 2012, 167: 67-73.

Teng L.L., Yeung M.Y., Yue G., Au-Yeung R.K.H., Yeung E.Y.H., Fung A.M.Y., Tse H., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., In silico analysis of 16S rRNA gene sequencing based methods for identification of medically important aerobic Gram-negative bacteria, Journal of Medical Microbiology. 2011, 2011, 60: 1281-1286.

Tse H., Lau S.K.P., Chan W.M., Choi K.Y., Woo P.C.Y. and Yuen K.Y., Complete genome sequences of novel canine noroviruses in Hong Kong, Journal of Virology. 2012, 86: 9531-9532.

Tse H., Chan W.M., Li K.S.M., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Discovery and genomic characterization of a novel bat sapovirus with unusual genomic features and phylogenetic position, PLoS One. 2012, 7: e34987.

Tse H., Tsoi H.W., Teng L.L., Chen X.C., Liu H., Zhou B., Zheng B., Woo P.C.Y., Lau S.K.P. and Yuen K.Y., Discovery and genomic characterization of a novel ovine partetravirus and a new genotype of bovine partetravirus, PLoS One. 2011, 6: e25619.

Tse H., Chan W.M., Tsoi H.W., Fan Y.Y., Lau C.Y., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Rediscovery and genomic characterization of bovine astroviruses, Journal of General Virology. 2011, 2011, 92: 1888-1898.

Wang Y.F., Cai J.P., Wang Y.D., Dong H., Hao W., Jiang L.X., Long J., Chan C.M., Woo P.C.Y., Lau S.K.P., Yuen K.Y. and Che X.Y., Immunoassays based on Penicillium marneffei Mp1p derived from Pichia pastoris expression system for diagnosis of penicilliosis, PLoS One. 2011, 6: e28796.

Wong M.Y., Lau S.K.P., Tang S.C.W., Curreem S.O.T., Woo P.C.Y. and Yuen K.Y., First Report of Peritoneal Dialysis-Related Peritonitis Caused by Citrobacter amalonaticus, Peritoneal Dialysis International. 2012, 32: 224-225.

Woo P.C.Y., Leung S.Y., Ngan A.H.Y., Lau S.K.P. and Yuen K.Y., A significant number of reported Absidia corymbifera (Lichtheimia corymbifera) infections are caused by Lictheimia ramosa (syn. Lichtheimia hongkongensis): an emerging cause of mucormycosis, Emerging Microbes & Infections. 2012, 1: e12.

Woo P.C.Y., Lau S.K.P., Wong B.H.L., Wong Y.P., Poon W.S.R. and Yuen K.Y., Complete genome sequence of a novel paramyxovirus, Tailam virus, discovered in Sikkim rats, Journal of Virology. 2011, 85: 13473-13474.

Woo P.C.Y., Lau S.K.P., Bai R., Teng L.L., Lee P., Martelli P., Hui S.W. and Yuen K.Y., Complete genome sequence of a novel picobirnavirus, otarine picobirnavirus, discovered in California sea lions, Journal of Virology. 2012, 86: 6377-6378.

Woo P.C.Y., Lau S.K.P., Lam S.F., Lau C.Y., Tsang K.L., Lau J.H.N., Bai R., Teng L.L., Tsang C.C.C., Wang M., Zheng B., Chan K.H. and Yuen K.Y., Discovery of seven novel mammalian and avian coronaviruses in Deltacoronavirus supports bat coronaviruses as the gene source of Alphacoronavirus and Betacoronavirus and avian coronaviruses as the gene source of Gammacoronavirus and Deltacoronavirus, Journal of Virology. 2012, 86: 3995-4008.

Woo P.C.Y., Lau S.K.P., Liu B., Cai J.J., Chong T.K., Tse H., Kao R.Y.T., Chan C.M., Chow W.N. and Yuen K.Y., Draft genome sequence of Penicillium marneffei strain PM1, Eukaryotic Cell. 2011, 10: 1740-1741.

Woo P.C.Y., Lau S.K.P., Wong B.H.L., Fan Y.Y., Wong Y.P., Zhang J., Wu Y., Choi K.Y., Li K.S.M., Hui J., Wang M., Zheng B., Chan K.H. and Yuen K.Y., Feline morbillivirus, a previously undescribed paramyxovirus associated with tubulointerstitial nephritis in domestic cats, Proceedings of the National Academy of Sciences of the USA. 2012, 109: 5435-5440.

Woo P.C.Y., Lau S.K.P., Choi K.Y., Huang Y., Teng L.L., Tsoi H.W., Tse H., Yeung M.L., Chan K.H., Jin D. and Yuen K.Y., Natural occurrence and characterization of two IRES elements in a novel virus, canine picodicistrovirus, in the picornavirus-like superfamily, Journal of Virology. 2011, 86: 2797-2808.

Woo P.C.Y., Lau S.K.P., Wong B.H.L., Wu Y., Lam S.F. and Yuen K.Y., Novel variant of Beilong paramyxovirus in rats, China, Emerging Infectious Diseases. 2012, 18: 1022-1024.

Yang W., Chen W., Wang H., Ho J.W.S., Huang J., Woo P.C.Y., Lau S.K.P., Yuen K.Y., Zhang Q., Zhou W., Bartlam M., Watt R.M. and Rao Z., Structural and functional insight into the mechanism of an alkaline exonuclease from Laribacter hongkongensis, Nucleic Acids Research. 2011, 39(22): 9803-19.

Yip C.Y., Lau S.K.P., Woo P.C.Y., Chan K.H. and Yuen K.Y., Complete genome sequence of a coxsackievirus A22 strain in Hong Kong reveals a natural intratypic recombination event, Journal of Virology . 2011, 85: 12098-12099.

Researcher : Lau SY

List of Research Outputs

Chen Y., Zheng Q., Zeng F., Lau S.Y., Wu W.L., Huang S., Zhang J., Chen H. and Xia N., Serological survey of antibodies to influenza A viruses in a group of people without a history of influenza vaccination, Clinical Microbiology and Infection. 2011, 17: 1347-9.

Lai A.C.K., Wu W.L., Lau S.Y., Guan Y. and Chen H., Two-dimension antigenic dendrogram and phylogenetic tree of avian influenza virus H5N1, FEMS Immunol Med Microbiol. 2011, 64: 205-11.

Wu W.L., Lau S.Y., Chen Y., Wang G., Mok B.W.Y., Wen X., Wang P., Song W., Lin T., Chan K.H., Yuen K.Y. and Chen H., 2008-2009 H1N1 influenza virus exhibits reduced susceptibility to antibody inhibition: implications for the prevalence of oseltamivir resistant variant viruses, Antiviral Research. . 2011, 93: 144-53.

Researcher : Lee MY

Project Title:	Direct identification and quantification of host and viral microRNAs after influenza infection using the next generation ultra-high throughput DNA sequencer
Investigator(s):	Lee MY, Lok S, Cheung CY
Department:	Microbiology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	05/2009

Project Title:	Host response of the highly pathogenic avian influenza viruses
Investigator(s):	Lee MY, Peiris JSM
Department:	School of Public Health
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

List of Research Outputs

Hui P.Y., Lee M.Y., Cheung C.Y., Mao H., Lai K.W., Chan W.Y., Chan M.C.W., Tu W., Guan Y., Lau Y.L. and Peiris J.S.M., H5N1 influenza virus-induced mediators upregulate RIG-I in uninfected cells by paracrine effects contributing to amplified cytokine cascades, The Journal of Infectious Diseases. 2011, 204(12): 1866-1878.

Lee M.Y., Gai W., Cheung K.W. and Peiris J.S.M., Antiviral activity of a selective COX-2 inhibitor on H5N1 infection in vitro., Antiviral Research. 2011, 91(3): 330-4.

Researcher : Lee P

List of Research Outputs

Lau S.K.P., Woo P.C.Y., Lai K.Y., Huang Y., Yip C.Y., Shek C.T., Lee P., Lam S.F., Chan K.H. and Yuen K.Y., Complete genome analysis of three novel picornaviruses from diverse bat species, Journal of Virology. 2011, 85: 8819-8828.

Lau S.K.P., Lee P., Tsang K.L., Yip C.Y., Tse H., Lee R.A., So L.Y., Lau Y.L., Chan K.H., Woo P.C.Y. and Yuen K.Y., Molecular epidemiology of human coronavirus OC43 reveals evolution of different genotypes over time and recent emergence of a novel genotype due to natural recombination., Journal of Virology. 2011, 85: 11325-11337.

Woo P.C.Y., Lau S.K.P., Bai R., Teng L.L., Lee P., Martelli P., Hui S.W. and Yuen K.Y., Complete genome sequence of a novel picobirnavirus, otarine picobirnavirus, discovered in California sea lions, Journal of Virology. 2012, 86: 6377-6378.

Researcher : Lee RA

List of Research Outputs

Lau S.K.P., Lee P., Tsang K.L., Yip C.Y., Tse H., Lee R.A., So L.Y., Lau Y.L., Chan K.H., Woo P.C.Y. and Yuen K.Y., Molecular epidemiology of human coronavirus OC43 reveals evolution of different genotypes over time and recent emergence of a novel genotype due to natural recombination., Journal of Virology. 2011, 85: 11325-11337.

Researcher : Leung SY

List of Research Outputs

Woo P.C.Y., Leung S.Y., Ngan A.H.Y., Lau S.K.P. and Yuen K.Y., A significant number of reported Absidia corymbifera (Lichtheimia corymbifera) infections are caused by Lictheimia ramosa (syn. Lichtheimia hongkongensis): an emerging cause of mucormycosis, Emerging Microbes & Infections. 2012, 1: e12.

Researcher : Li KSM

List of Research Outputs

Tao Y., Tang K., Shi M., Conrardy C., Li K.S.M., Lau S.K.P., Anderson L.J. and Tong S., Genomic characterization of seven distinct bat coronaviruses in Kenya, Virus Research. 2012, 167: 67-73.

Tse H., Chan W.M., Li K.S.M., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Discovery and genomic characterization of a novel bat sapovirus with unusual genomic features and phylogenetic position, PLoS One. 2012, 7: e34987.

Woo P.C.Y., Lau S.K.P., Wong B.H.L., Fan Y.Y., Wong Y.P., Zhang J., Wu Y., Choi K.Y., Li K.S.M., Hui J., Wang M., Zheng B., Chan K.H. and Yuen K.Y., Feline morbillivirus, a previously undescribed paramyxovirus associated with tubulointerstitial nephritis in domestic cats, Proceedings of the National Academy of Sciences of the USA. 2012, 109: 5435-5440.

Researcher : Li L

List of Research Outputs

Zhu H., Li L., Zeng Y., Zhou J., Zheng Z., Chen R., Zheng R., Duan L., Yip C.H., Huang K., Lam T.Y., Wang J., Chen H., Webster R.G., Webby R., Peiris J.S.M., Smith D.K. and Guan Y., Pandemic H1N1/2009 virus in swine: prevalence and genesis of reassortants with the potential to infect humans., 4th International Influenza Conference: Influenza2011 Zoonotic Influenza and Human Health. 2011.

Researcher : Li OTW

Project Title:	Genome-wide identification of transcription control influenced by influenza infections
Investigator(s):	Li OTW, Poon LLM
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	08/2010
Completion Date:	01/2012

List of Research Outputs

Yen H., Liang C.-.H., Wu C.-.Y., Forrest H., Ferguson A., Choy K.T., Jones J., Wong D.D.Y., Cheung P.H.P., Hsu C.-.H., Li O.T.W., Yuen K.M., Chan W.Y., Poon L.L.M., Chan M.C.W., Nicholls J.M., Krauss S., Wong C.-.H., Guan Y., Webster R.G., Webby R. and Peiris J.S.M., Hemagglutinin-neuraminidase balance confers respiratory-droplet transmissibility of the pandemic H1N1 influenza virus in ferrets, Proceedings of National Academic Science (USA). 2011, 108: 14264-14269.

Researcher : Li WS

List of Research Outputs

Lau S.K.P., Fan Y.Y., Lo H.W., Ng R.H.Y., Wong S.S.Y., Li W.S., Wu A.K.L., Ng K.H.L., Tseung S., Lee R.A., Fung K.S.C., Que T.L., Yuen K.Y. and Woo P.C.Y., High mortality associated with Catabacter hongkongensis bacteremia, Journal of Clinical Microbiology. 2012, 50: 2239-2243.

Researcher : Li Z

List of Research Outputs

Ho P.L., Yeung M.K., Lo W.U., Tse H., Li Z., Lai E.L.Y., Chow K.H., To K.K.W. and Yam W.C., Predominance of pHK01-like incompatibility group FII plasmids encoding CTX-M-14 among extended-spectrum beta-lactamase-producing Escherichia coli in Hong Kong, 1996-2008, Diagnostic Microbiology and Infectious Diseases. 2012, 73: 182-186.

Researcher : Liang J

List of Research Outputs

Kang Y., Wu Z., Lau T., Lu X., Liu L., Cheung K.L.A., Tan Z., Ng J., Liang J., Wang H., Li S., Zheng B., Li B., Chen L. and Chen Z., CCR5 Antagonist TD-0680 Uses a Novel Mechanism for Enhanced Potency against HIV-1 Entry, Cell-mediated Infection, and a Resistant Variant, JBC. JBC, 2012, 287: 16499.

Researcher : Liu L

Project Title:	Early HIV-1 diagnosis using in-house real-time PCR amplification on dried blood spots for men who have sex with men in Hong Kong
Investigator(s):	Liu L
Department:	Medical Faculty
Source(s) of Funding:	Council for the AIDS Trust Fund - General Award
Start Date:	09/2009

Project Title:	Identification of small molecule HIV-1 inhibitors with distinct new targets
Investigator(s):	Liu L
Department:	Medical Faculty
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	02/2012

Project Title:	The role of HIV-1/SIV Nef in immune activation through regulating the expression of PD-1 and delta-PD-1
Investigator(s):	Liu L, Chen Z
Department:	Medical Faculty
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	03/2012

List of Research Outputs

Kang Y., Wu Z., Lau T., Lu X., Liu L., Cheung K.L.A., Tan Z., Ng J., Liang J., Wang H., Li S., Zheng B., Li B., Chen L. and Chen Z., CCR5 Antagonist TD-0680 Uses a Novel Mechanism for Enhanced Potency against HIV-1 Entry, Cell-mediated Infection, and a Resistant Variant, JBC. JBC, 2012, 287: 16499.

Yao X., Wang H., Yan P., Lu Y., Lin H., Chen L., Ng J., Liu L. and Chen Z., Rising epidemic of HIV-1 infections among general populations in Fujian, China., JAIDS. JAIDS, 2012, 60: 328.

Researcher : Lo KC

List of Research Outputs

Lo K.C., Lo K.C., Zhu G., Sze K.H. and Sze K.H., Study on the interaction between DNA-binding domain (DBD) of human androgen receptor (AR) and SWIRM domain of lysine-specific demethylase 1 (LSD1), Croucher Advanced Study Institute - Structure-Based Sreening and Design of Ligands for Protein Targets, December 12-15, 2011, CUHK . 2011, Abstract, A09.

Researcher : Lo WU

List of Research Outputs

Ho P.L., Lo W.U., Lai E.L.Y., Chow K.H. and Yam W.C., Escherichia coli O25b-ST131 is an important cause of antimicrobial-resistant infections in women with uncomplicated cystitis, Journal of Antimicrobial Chemotherapy. 2012.

Ho P.L., Yeung M.K., Lo W.U., Tse H., Li Z., Lai E.L.Y., Chow K.H., To K.K.W. and Yam W.C., Predominance of pHK01-like incompatibility group FII plasmids encoding CTX-M-14 among extended-spectrum beta-lactamase-producing Escherichia coli in Hong Kong, 1996-2008, Diagnostic Microbiology and Infectious Diseases. 2012, 73: 182-186.

Lo W.U. and Ho P.L., Epidemiology of CTX-M type extended-spectrum beta-lactamases in escherichia coli isolates from human and animals, (Pokfulam Road, Hong Kong, University of Hong Kong, 2011.

Researcher : Lu X

List of Research Outputs

Kang Y., Wu Z., Lau T., Lu X., Liu L., Cheung K.L.A., Tan Z., Ng J., Liang J., Wang H., Li S., Zheng B., Li B., Chen L. and Chen Z., CCR5 Antagonist TD-0680 Uses a Novel Mechanism for Enhanced Potency against HIV-1 Entry, Cell-mediated Infection, and a Resistant Variant, JBC. JBC, 2012, 287: 16499.

Lu X., Liu L., Zhang X., Lau T.C., Tsui S.K., Kang Y., Zheng P., Zheng B., Liu G. and Chen Z., F18, a novel small molecule NNRTI, inhibits HIV-1 replication using distinct binding motifs as demonstrated by resistance selection and docking analysis, Antimicrob Agents Chemother. 2012, Jan: 56(1): 341-51.

Researcher : Ma SK

List of Research Outputs

Perera R.A.P.M., Riley S., Ma S.K., Zhu H., Guan Y. and Peiris J.S.M., Seroconversion to pandemic (H1N1) 2009 virus and cross-reactive immunity to other swine influenza viruses., Emerging Infectious Diseases. 2011, 17: 1897-1899.

Wu J.T.K., Leung S.M., Ma S.K., Lee C.K., Chu K.W., Ho P.L., Hung I.F.N., Ho L.M., Lin C.K., Tsang T., Lo S.V., Lau Y.L., Leung G.M., Cowling B.J. and Peiris J.S.M., Characterizing the transmission dynamics and severity of the 2009 influenza pandemic in Hong Kong (abstract and poster presentation), Hong Kong College of Community Medicine Annual Scientific Meeting on 27 November 2011 in Hong Kong. Hong Kong, Hong Kong College of Community Medicine, 2011.

Wu J.T.K., Ho W.K., Ma S.K., Lee C.K., Chu K.W., Ho P.L., Hung I.F.N., Ho L.M., Lin C.K., Tsang T.H.F., Lo S.V., Lau Y.L., Leung G.M., Cowling B.J. and Peiris J.S.M., Estimating infection attack rates and severity in real time during an influenza pandemic: analysis of serial cross-sectional serologic surveillance data, PLoS Medicine. 2011, 8(10): e1001103.

Zhou Y., Ng M.W., Seto W.H., Ip D.K.M., Kwok H.K.H., Ma S.K., Ng S., Lau L.H.L., Wu J.T.K., Peiris J.S.M. and Cowling B.J., Seroprevalence of antibody to pandemic influenza A (H1N1) 2009 among healthcare workers after the first wave in Hong Kong, Journal of Hospital Infection. 2011, 78(4): 308-311.

Zhou Y., Ng M.W., Seto W.H., Ip D.K.M., Kwok H.K.H., Ma S.K., Ng S., Lau L.H.L., Peiris J.S.M. and Cowling B.J., Seroprevalence of pandemic H1N1 antibody among health care workers in Hong Kong following receipt of monovalent 2009 H1N1 influenza vaccine, PLoS One. 2011, 6(11): e27169.

Zhou Y., Ng M.W., Seto W.H., Ip D.K.M., Kwok H.K.H., Ma S.K., Ng S., Lau L.H.L., Peiris J.S.M. and Cowling B.J., Suboptimal immunogenicity among healthcare workers after receipt of the monovalent 2009 influenza A(N1N1) vaccine (abstract and poster presentation), Hong Kong College of Community Medicine Annual Scientific Meeting on 27 November 2011 in Hong Kong. Hong Kong, Hong Kong College of Community Medicine, 2011.

Researcher : Mok BWY

Project Title:	Exploring the role of influenza A virus NS1 protein in microRNA-induced silencing complex (miRISC) regulation of gene expression
Investigator(s):	Mok BWY, Chen H
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	04/2012

List of Research Outputs

Wu W.L., Lau S.Y., Chen Y., Wang G., Mok B.W.Y., Wen X., Wang P., Song W., Lin T., Chan K.H., Yuen K.Y. and Chen H., 2008-2009 H1N1 influenza virus exhibits reduced susceptibility to antibody inhibition: implications for the prevalence of oseltamivir resistant variant viruses, Antiviral Research. . 2011, 93: 144-53.

Researcher : Mok KP

Project Title:	Role of calpain inhibitor as an antiviral and immunomodulatory agent in the treatment of severe human influenza H5N1 virus infection
Investigator(s):	Mok KP, Peiris JSM
Department:	School of Public Health
Source(s) of Funding:	Small Project Funding
Start Date:	01/2012
Completion Date:	12/2012

List of Research Outputs

Mok K.P., Yen H., Yu Y.M., Yuen K.M., Sia S.F., Chan M.C.W., Qin G., Tu W. and Peiris J.S.M., Amino Acid Residues 253 and 591 of the PB2 Protein of Avian Influenza Virus A H9N2 Contribute to Mammalian Pathogenesis, Journal of Virology. 2011, 85(18): 9641-9645.

Researcher : Ng IHY

List of Research Outputs

Qin G., Liu Y., Zheng J., Zheng X., Ng I.H.Y., Peiris J.S.M., Lau Y.L. and Tu W., Phenotypic and Functional Characterization of Human γδ T-Cell Subsets in Response to Influenza A Viruses, Journal of Infectious Diseases. 2012, 205(11): 1646-1653.

Qin G., Liu Y., Zheng J., Ng I.H.Y., Xiang Z., Lam K.T., Mao H., Li H., Peiris J.S.M., Lau Y.L. and Tu W., Type 1 Responses Of Human V9v2 T Cells To Influenza A Viruses, Journal of Virology. 2011, 85(19): 10109-10116.

Qin G., Liu Y., Zheng J., Ng I.H.Y., Xiang Z., Lam K.T., Mao H., Li H., Peiris J.S.M., Lau Y.L. and Tu W., Type-1 responses of human Vgamma9Vdelta2 T cells to influenza A viruses., J Virol. 2011.

Tu W., Zheng J., Liu Y., Sia S.F., Liu M., Qin G., Ng I.H.Y., Xiang Z., Lam K.T., Peiris J.S.M. and Lau Y.L., The aminobisphosphonate pamidronate controls influenza pathogenesis by expanding a gammadelta T cell population in humanized mice, Journal of Experimental Medicine. 2011, 208(7): 1511-1522.

Researcher : Ng SP

Project Title:	Collection of background information on the alternative faecal indicators in the environmental waters of Hong Kong and their correlation with Escherichia coli
Investigator(s):	Ng SP, Yam WC
Department:	Microbiology
Source(s) of Funding:	Environment Protection Department - General Award
Start Date:	06/2001

Researcher : Ngan HY

List of Research Outputs

Lau S.K.P., Curreem S.O.T., Ngan H.Y., Yeung C.K., Yuen K.Y. and Woo P.C.Y., First report of disseminated Mycobacterium skin infections in two liver transplant recipients and rapid diagnosis by hsp65 gene sequencing, Journal of Clinical Microbiology. 2011, 49: 3733-3737.

Researcher : Peiris JSM

Project Title:	IV International Symposium on Respiratory Viral Infections The Influenza Disease Burden in Hong Kong: the Rates of Hospitalisation in Children
Investigator(s):	Peiris JSM
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2001

Project Title:	Influenza pandemic preparedness in Asia (Research collaboration with national Institute of Allergy and Infectious Diseases (NIAID), St. Jude Children's Research Hospital, Inc. (SJCRH) and The University of Hong Kong)
Investigator(s):	Peiris JSM, Guan Y
Department:	Microbiology
Source(s) of Funding:	National Institutes of Health, US Department of Health and Human Services - General Award
Start Date:	04/2003

Project Title:	Virus-cell interaction and the pathogenesis of SARS
Investigator(s):	Peiris JSM
Department:	Microbiology
Source(s) of Funding:	VCO SARS Research Fund
Start Date:	07/2003

Project Title:	Viral determinants underlying the increased secretion of pro-inflammatory cytokines in H5N1 infected human macrophages: a mechanism for the unusual severity of human H5N1 disease?
Investigator(s):	Peiris JSM, Guan Y, Lau ASY, Poon LLM
Department:	Microbiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2003

Project Title:	The macrophage in the pathogenesis of Severe Acute Respiratory Syndrome Coronavirus infection
Investigator(s):	Peiris JSM
Department:	Microbiology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	12/2005

Project Title:	Mass Tag PCR: A novel, multiplex and potentially sensitive approach for the rapid detection of respiratory pathogens
Investigator(s):	Peiris JSM, Chiu SSS, Cheung CY
Department:	Microbiology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	06/2006

Project Title:	The pathogenesis of avian influenza A H5N1 in humans: macrophage and epithelial cell-virus interactions in vitro and ex-vivo
Investigator(s):	Peiris JSM
Department:	Microbiology
Source(s) of Funding:	The Wellcome Trust - General Award
Start Date:	01/2007

Project Title:	Communicable Diseases Surveillance and Response (CSR) - Standardization and shipment of PCR diagnostic kit for Avian Influenza detection to Member countries (viz: Bangladesh, Indonesia, Myanmar, Sri Lanka and Thailand)
Investigator(s):	Peiris JSM
Department:	Microbiology
Source(s) of Funding:	Collaborating Project Fund
Start Date:	06/2007

Project Title:	Control of Pandemic and Inter-pandemic Influenza
Investigator(s):	Peiris JSM, Guan Y, Yuen KY, Chen H, Leung GM, Lau YL
Department:	Microbiology
Source(s) of Funding:	Areas of Excellence Scheme
Start Date:	01/2008

Project Title:	The role of Toll-like receptor 10 (TLR10) as an innate immune sensor for respiratory viral infections
Investigator(s):	Peiris JSM, Lee MY, Nicholls JM
Department:	Microbiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2011

List of Research Outputs

Cowling B.J., Chan K.H., Klick B.A., Durrani S., Chou S.K., Wong S.T., Kam M.S., Kwok H.K.H., Ng S., Chiu S.S.S., Peiris J.S.M. and Ip D.K.M., Efficacy of live attenuated seasonal and pandemic influenza vaccine in school-age children: A randomized controlled trial (abstract), 4th ESWI Influenza Conference on 11-14 September 2011 in Malta. Malta, European Scientific Working Group on Influenza, 2011, A508P.

Cowling B.J., Klick B.A., Ng S., Fang J., Leung G.M., Peiris J.S.M. and Nishiura H., Estimation of household and community transmission parameters of seasonal and pandemic influenza in a cohort of households in Hong Kong (abstract), 4th ESWI Influenza Conference on 11-14 September 2011 in Malta. Malta, European Scientific Working Group on Influenza, 2011.

Cowling B.J., Fang J., Nishiura H., Chan K.H., Ng S., Ip D.K.M., Chiu S.S.S., Leung G.M. and Peiris J.S.M., Increased risk of non-influenza respiratory virus infections associated with receipt of inactivated influenza vaccine, Clinical Infectious Diseases. 2012, 54(12): 1778-83.

Cowling B.J., Wu J.T.K. and Peiris J.S.M., Reply to Kok and Dwyer (letter), Clinical Infectious Diseases. 2011, 53(1): 101-103.

Ekiert D.C., Friesen R.H., Bhabha G., Kwaks T., Jongeneelen M., Yu W., Ophorst C., Cox F., Korse H.J., Brandenburg B., Vogels R., Brakenhoff J.P., Kompier R., Koldijk M.H., Cornelissen L.A., Poon L.L.M., Peiris J.S.M., Koudstaal W., Wilson I.A. and Goudsmit J., A Highly Conserved Neutralizing Epitope on Group 2 Influenza A Viruses., Science. 2011.

Hui P.Y., Lee M.Y., Cheung C.Y., Mao H., Lai K.W., Chan W.Y., Chan M.C.W., Tu W., Guan Y., Lau Y.L. and Peiris J.S.M., H5N1 influenza virus-induced mediators upregulate RIG-I in uninfected cells by paracrine effects contributing to amplified cytokine cascades, The Journal of Infectious Diseases. 2011, 204(12): 1866-1878.

Ip D.K.M., Schutten M., Fang J., Fung R.O.P., Dutkowski R.T., Chan K.H., Leung G.M., Peiris J.S.M. and Cowling B.J., Validation of self-swab for virologic confirmation of influenza virus infections in a community setting, Journal of Infectious Diseases. 2012, 205(4): 631-634.

Jaume M.D.A., Yip M.S., Cheung C.Y., Kien F.S., Li P.H., Dutry I.C.A., Bruzzone R., Peiris J.S.M., Nal-Rogier B.T.M. and Altmeyer R.M., Sars Cov Subunit Vaccine: Antibody-mediated Neutralisation And Enhancement., In: Jaume M, Yip MS, Kam YW, Cheung CY, Kien F, Roberts A, Li PH, Dutry I, Escriou N, Daeron M, Bruzzone R, Subbarao K, Peiris JS, Nal B, Altmeyer R, Hong Kong Med J.. Hong Kong, 2012, 18: Suppl 2:31-6.

Klick B.A., Nishiura H., Ng S., Fang J., Leung G.M., Peiris J.S.M. and Cowling B.J., Transmissibility of seasonal and pandemic influenza in a cohort of households in Hong Kong in 2009, Epidemiology. 2011, 22(6): 793-796.

Kudelko M.A., Brault J.B., Kwok K.T.H., Pardigon N., Peiris J.S.M., Bruzzone R., Despres P., Nal-Rogier B.T.M. and Wang P., Class II ADP-ribosylation Factors Are Required for Efficient Secretion of Dengue Viruses, The Journal of Biological Chemistry. 2012, 287 (1): 767-777.

Kwok K.O., Cowling B.J., Wei W.I., Wu K.M., Ning Y., Lessler J., Read J., Commings D.A., Peiris J.S.M. and Riley S., Social contacts and the transmission of influenza in Hong Kong during the main wave of the 2009 pandemic (abstract and poster presentation), Hong Kong College of Community Medicine Annual Scientific Meeting on 27 November 2011 in Hong Kong. Hong Kong, Hong Kong College of Community Medicine, 2011.

Lam T.Y., Zhu H., Wang J., Smith D.K., Holmes E.C., Webster R.G., Webby R., Peiris J.S.M. and Guan Y., Reassortment Events Among Swine Influenza A Viruses in China: Implications for the Origin of the 2009 Influenza Pandemic, J Virol. 2011, 85(19): 10279-85.

Lau L.H.L., Fang J., Chan K.H., Cheng K.Y., Leung G.M., Peiris J.S.M. and Cowling B.J., Influenza viral loads and infectivity (abstract and oral presentation), 16th Research Postgraduate Symposium on 7-8 December 2011 in Hong Kong. Hong Kong, LKS Faculty of Medicine, HKU, 2011, 3.16: 204.

Lee D.C.W., Law H.Y., Hui K., Tam A.H., Peiris J.S.M. and Lau A.S.Y., Interferon dysregulation and virus-induced cell death in avian influenza H5N1 virus infections. , Hong Kong Medical Journal. 2012; 18 Suppl 2:12-6. 2012.

Lee M.Y., Gai W., Cheung K.W. and Peiris J.S.M., Antiviral activity of a selective COX-2 inhibitor on H5N1 infection in vitro., Antiviral Research. 2011, 91(3): 330-4.

Ling M.T., Tu W., Han Y., Mao H., Chong W.P., Guan J., Liu M., Lam K.T., Law H.K.W., Peiris J.S.M., Takahashi K. and Lau Y.L., Mannose-Binding LectinContributes to Deleterious Inflammatory Response in Pandemic H1N1 and Avian H9N2 Infection, Journal of Infectious Diseases. 2012, 205(1): 44-53.

Mok K.P., Yen H., Yu Y.M., Yuen K.M., Sia S.F., Chan M.C.W., Qin G., Tu W. and Peiris J.S.M., Amino Acid Residues 253 and 591 of the PB2 Protein of Avian Influenza Virus A H9N2 Contribute to Mammalian Pathogenesis, Journal of Virology. 2011, 85(18): 9641-9645.

Qin G., Liu Y., Zheng J., Zheng X., Ng I.H.Y., Peiris J.S.M., Lau Y.L. and Tu W., Phenotypic and Functional Characterization of Human γδ T-Cell Subsets in Response to Influenza A Viruses, Journal of Infectious Diseases. 2012, 205(11): 1646-1653.

Qin G., Liu Y., Zheng J., Ng I.H.Y., Xiang Z., Lam K.T., Mao H., Li H., Peiris J.S.M., Lau Y.L. and Tu W., Type 1 Responses Of Human V9v2 T Cells To Influenza A Viruses, Journal of Virology. 2011, 85(19): 10109-10116.

Qin G., Liu Y., Zheng J., Ng I.H.Y., Xiang Z., Lam K.T., Mao H., Li H., Peiris J.S.M., Lau Y.L. and Tu W., Type-1 responses of human Vgamma9Vdelta2 T cells to influenza A viruses., J Virol. 2011.

Trevennec K.A.R.E.N., Chevalier V., Grosbois V., Garcia J.C., Ho Thu H., Berthouly–Salazar C., Peiris J.S.M. and Roger F., Looking for avian influenza in remote areas. A case study in Northern Vietnam., Acta Tropica. 2011, 120: 160-6.

Tu W., Zheng J., Liu Y., Sia S.F., Liu M., Qin G., Ng I.H.Y., Xiang Z., Lam K.T., Peiris J.S.M. and Lau Y.L., The aminobisphosphonate pamidronate controls influenza pathogenesis by expanding a gammadelta T cell population in humanized mice, Journal of Experimental Medicine. 2011, 208(7): 1511-1522.

Wang X., Yang L., Chan K.P., Chiu S.S.S., Chan K.H., Peiris J.S.M. and Wong C.M., Model selection in time series studies of influenza-associated mortality, PLoS One. 2012, 7(6): e39423.

Wang X., Yang L., Chan K.P., Chiu S.S.S., Chan K.H., Peiris J.S.M. and Wong C.M., Performance of model selection criteria in time series studies of influenza-associated mortality (abstract and poster presentation), 16th Research Postgraduate Symposium on 7-8 December 2011 in Hong Kong. 2011, 4.26: 131.

Wang X., Yang L., Chan K.P., Chiu S.S.S., Chan K.H., Peiris J.S.M. and Wong C.M., Performance of three influenza activity proxy variables for estimating age-specific hospitalization associated with influenza in Hong Kong (abstract and poster presentation), Hong Kong College of Community Medicine Annual Scientific Meeting on 27 November 2011 in Hong Kong. Hong Kong, Hong Kong College of Community Medicine, 2011.

Wong C.M., Yang L., Chan K.P., Song L., Lai H.K., Thach T.Q., Ho L.M., Lam T.H. and Peiris J.S.M., Effect modifications of smoking on risk of mortality associated with influenza (abstract), International Society for Environmental Epidemiology, 13-16 September 2011, Barcelona. Barcelona, ISEE, 2011.

Wong C.M., Peiris J.S.M., Yang L., Chan K.P., Thach T.Q., Lai H.K., Lim W.W.L., Hedley A.J., He J., Chen P., Ou C., Deng A., Zhang X., Zhou D., Ma S.S.L. and Chow A., Effect of influenza on cardiorespiratory and all-cause mortality in Hong Kong, Singapore and Guangzhou, Hong Kong Medical Journal. 2012, 18(Suppl 2): S8-S11.

Wu J.T.K., Leung S.M., Ma S.K., Lee C.K., Chu K.W., Ho P.L., Hung I.F.N., Ho L.M., Lin C.K., Tsang T., Lo S.V., Lau Y.L., Leung G.M., Cowling B.J. and Peiris J.S.M., Characterizing the transmission dynamics and severity of the 2009 influenza pandemic in Hong Kong (abstract and poster presentation), Hong Kong College of Community Medicine Annual Scientific Meeting on 27 November 2011 in Hong Kong. Hong Kong, Hong Kong College of Community Medicine, 2011.

Wu J.T.K., Ho W.K., Ma S.K., Lee C.K., Chu K.W., Ho P.L., Hung I.F.N., Ho L.M., Lin C.K., Tsang T.H.F., Lo S.V., Lau Y.L., Leung G.M., Cowling B.J. and Peiris J.S.M., Estimating infection attack rates and severity in real time during an influenza pandemic: analysis of serial cross-sectional serologic surveillance data, PLoS Medicine. 2011, 8(10): e1001103.

Wu J.T.K., Ho A.L.Y., Ma E., Lee C.K., Chu D., Ho P.L., Hung I.F.N., Lin C.K., Tsang T., Lo S.V., Lau Y.L., Leung G.M., Cowling B.J. and Peiris J.S.M., Estimating infection attack rates and severity in real-time during an influenza pandemic (abstract), 4th ESWI Influenza Conference on 11-14 September 2011 in Malta. Malta, European Scientific Working Group on Influenza, 2011, B619P.

Yang L., Chen P., He J.F., Chan K.P., Ou C., Deng A.P., Peiris J.S.M. and Wong C.M., Effect modification of environmental factors on influenza-associated mortality: A time-series study in two Chinese cities, BMC Infectious Diseases. 2011, 11: 342.

Yang L., Chan K.P., Chan W.M., Song L., Lai H.K., Thach T.Q., Ho L.M., Lam T.H., Peiris J.S.M. and Wong C.M., Effect of exercise on mortality risk associated with influenza: Evidence from an elderly cohort in Hong Kong (abstract and poster presentation), 4th ESWI Influenza Conference on 11-14 September 2011 in Malta. Malta, European Scientific Working Group on Influenza, 2011, A110P.

Yang L., Chan K.P., Chen P., He J.F., Ou C., Peiris J.S.M. and Wong C.M., Effects of environmental factors on influenza seasonality in the subtropics (abstract and oral presentation),, International Society for Environmental Epidemiology, 13-16 September 2011, Barcelona. Barcelona, ISEE, 2011.

Yang L., Chan K.P., Chen P., He J.F., Ou C., Peiris J.S.M. and Wong C.M., Environmental factors and mortality risks associated influenza (abstract and poster presentation),, International Society for Environmental Epidemiology, 13-16 September 2011, Barcelona. Barcelona, ISEE, 2011.

Yang L., Chan K.P., Cowling B.J., Chiu S.S.S., Chan K.H., Peiris J.S.M. and Wong C.M., Estimation of mortality burden associated with 2009 pandemic H1N1 in Hong Kong (abstract), 4th ESWI Influenza Conference on 11-14 September 2011 in Malta. Malta, European Scientific Working Group on Influenza, 2011, B608P.

Yang L., Ma S.S.L., Chen P., He J.F., Chan K.P., Chow A., Ou C., Deng A.P., Hedley A.J., Wong C.M. and Peiris J.S.M., Influenza associated mortality in the subtropics and tropics: results from three Asian cities, Vaccine. 2011, 29(48): 8909-8914.

Yen H., Liang C.-.H., Wu C.-.Y., Forrest H., Ferguson A., Choy K.T., Jones J., Wong D.D.Y., Cheung P.H.P., Hsu C.-.H., Li O.T.W., Yuen K.M., Chan W.Y., Poon L.L.M., Chan M.C.W., Nicholls J.M., Krauss S., Wong C.-.H., Guan Y., Webster R.G., Webby R. and Peiris J.S.M., Hemagglutinin-neuraminidase balance confers respiratory-droplet transmissibility of the pandemic H1N1 influenza virus in ferrets, Proceedings of National Academic Science (USA). 2011, 108: 14264-14269.

Yu C.L., Chan W.Y., Wang J., Travanty E.A., Nicholls J.M., Peiris J.S.M., Mason R.J. and Chan M.C.W., Viral Replication and Innate Host Responses in Primary Human Alveolar Epithelial Cells and Alveolar Macrophages Infected with Influenza H5N1 and H1N1 Viruses. , Journal of Virology. 2011, 85 (14): 6844-6855.

Zhou Y., Ng M.W., Seto W.H., Ip D.K.M., Kwok H.K.H., Ma S.K., Ng S., Lau L.H.L., Wu J.T.K., Peiris J.S.M. and Cowling B.J., Seroprevalence of antibody to pandemic influenza A (H1N1) 2009 among healthcare workers after the first wave in Hong Kong, Journal of Hospital Infection. 2011, 78(4): 308-311.

Zhou Y., Ng M.W., Seto W.H., Ip D.K.M., Kwok H.K.H., Ma S.K., Ng S., Lau L.H.L., Peiris J.S.M. and Cowling B.J., Seroprevalence of pandemic H1N1 antibody among health care workers in Hong Kong following receipt of monovalent 2009 H1N1 influenza vaccine, PLoS One. 2011, 6(11): e27169.

Zhou Y., Ng M.W., Seto W.H., Ip D.K.M., Kwok H.K.H., Ma S.K., Ng S., Lau L.H.L., Peiris J.S.M. and Cowling B.J., Suboptimal immunogenicity among healthcare workers after receipt of the monovalent 2009 influenza A(N1N1) vaccine (abstract and poster presentation), Hong Kong College of Community Medicine Annual Scientific Meeting on 27 November 2011 in Hong Kong. Hong Kong, Hong Kong College of Community Medicine, 2011.

Zhu H., Li L., Zeng Y., Zhou J., Zheng Z., Chen R., Zheng R., Duan L., Yip C.H., Huang K., Lam T.Y., Wang J., Chen H., Webster R.G., Webby R., Peiris J.S.M., Smith D.K. and Guan Y., Pandemic H1N1/2009 virus in swine: prevalence and genesis of reassortants with the potential to infect humans., 4th International Influenza Conference: Influenza2011 Zoonotic Influenza and Human Health. 2011.

Researcher : Poon KM

List of Research Outputs

Chan H.M., Chen L., Liu M., Hu L., Zheng B., Poon K.M., Huang P., Yuan Y.F., Huang J., Yang J., Tsao G.S.W. and Guan X., Translationally controlled tumor protein induces mitotic defects and chromosome missegregation in hepatocellular carcinoma development. , Hepatology . 2012, 55: 491-505.

Researcher : Poon LLM

Project Title:	Reverse genetic for a coronavirus responsible for severe acute respiratory syndrome
Investigator(s):	Poon LLM, Guan Y
Department:	Microbiology
Source(s) of Funding:	VCO SARS Research Fund
Start Date:	07/2003

Project Title:	International Conference on Options for Control of Influenza V Genetic Characterization of a Novel Coronavirus Responsible for Severe Acute Respiratory Syndrome A Coronavirus Responsible for Severe Acute Respiratory Syndrome
Investigator(s):	Poon LLM
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/2003

Project Title:	Centre for Research into Circulating Fetal Nucleic Acids
Investigator(s):	Poon LLM
Department:	Microbiology
Source(s) of Funding:	Areas of Excellence Scheme
Start Date:	01/2008

Project Title:	Development of reverse trasncriptase-polymerase chain reaction for the detection of ressortants bewteen pandemic H1N1/2009 and other influenza viruses
Investigator(s):	Poon LLM
Department:	Microbiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2011
Completion Date:	12/2011

Project Title:	Retrospective studies of pandemic and seasonal human influenza viral polymerase complexes
Investigator(s):	Poon LLM
Department:	Microbiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2011

Project Title:	Epigenomic modifications induced by influenza A infection
Investigator(s):	Poon LLM, Li OTW
Department:	School of Public Health
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2012

List of Research Outputs

Ekiert D.C., Friesen R.H., Bhabha G., Kwaks T., Jongeneelen M., Yu W., Ophorst C., Cox F., Korse H.J., Brandenburg B., Vogels R., Brakenhoff J.P., Kompier R., Koldijk M.H., Cornelissen L.A., Poon L.L.M., Peiris J.S.M., Koudstaal W., Wilson I.A. and Goudsmit J., A Highly Conserved Neutralizing Epitope on Group 2 Influenza A Viruses., Science. 2011.

Poon L.L.M., Coronavirus in wildlife , The XIIth International Symposium of Nidoviruses, Michigan, USA.. 2011.

Poon L.L.M., Universal vaccine for influenza A virus, The 2010 Annual Scientific Meeting of the Institut Pasteur International Network, Hong Kong. . 2011.

Yen H., Liang C.-.H., Wu C.-.Y., Forrest H., Ferguson A., Choy K.T., Jones J., Wong D.D.Y., Cheung P.H.P., Hsu C.-.H., Li O.T.W., Yuen K.M., Chan W.Y., Poon L.L.M., Chan M.C.W., Nicholls J.M., Krauss S., Wong C.-.H., Guan Y., Webster R.G., Webby R. and Peiris J.S.M., Hemagglutinin-neuraminidase balance confers respiratory-droplet transmissibility of the pandemic H1N1 influenza virus in ferrets, Proceedings of National Academic Science (USA). 2011, 108: 14264-14269.

Researcher : Poon WSR

List of Research Outputs

Woo P.C.Y., Lau S.K.P., Wong B.H.L., Wong Y.P., Poon W.S.R. and Yuen K.Y., Complete genome sequence of a novel paramyxovirus, Tailam virus, discovered in Sikkim rats, Journal of Virology. 2011, 85: 13473-13474.

Researcher : Sia SF

List of Research Outputs

Mok K.P., Yen H., Yu Y.M., Yuen K.M., Sia S.F., Chan M.C.W., Qin G., Tu W. and Peiris J.S.M., Amino Acid Residues 253 and 591 of the PB2 Protein of Avian Influenza Virus A H9N2 Contribute to Mammalian Pathogenesis, Journal of Virology. 2011, 85(18): 9641-9645.

Tu W., Zheng J., Liu Y., Sia S.F., Liu M., Qin G., Ng I.H.Y., Xiang Z., Lam K.T., Peiris J.S.M. and Lau Y.L., The aminobisphosphonate pamidronate controls influenza pathogenesis by expanding a gammadelta T cell population in humanized mice, Journal of Experimental Medicine. 2011, 208(7): 1511-1522.

Researcher : Siu GKH

List of Research Outputs

Cheng V.C.C., Yam W.C., Yau M.C.Y., Siu G.K.H., Wong S.C.Y., Chan J.F.W., To K.K.W., Tse H., Hung I.F.N., Tai J.W.M., Ho P.L. and Yuen K.Y., Epidemiology Of Klebsiella Oxytoca-associated Diarrhea Detected By Simmons Citrate Agar Supplemented With Inositol, Tryptophan, And Bile Salts., J Clin Microbiol. 2012, 50(5):1571-9.

Cheng V.C.C., Yam W.C., Tsang L.L., Yau M.C.Y., Siu G.K.H., Wong S.C.Y., Chan J.F.W., To K.K.W., Tse H., Hung I.F.N., Tai J.W.M., Ho P.L. and Yuen K.Y., Epidemiology of Klebsiella oxytoca-associated diarrhea detected by Simmons citrate agar supplemented with inositol, tryptophan, and bile salts, Journal of Clinical Microbiology. 2012, 50: 1571-9.

Researcher : Smith DK

Project Title:	Patterns in proteins with unusual flexibility profiles
Investigator(s):	Smith DK
Department:	Biochemistry
Source(s) of Funding:	Seed Funding for New Staff
Start Date:	08/2002

List of Research Outputs

Yu B., Yang M., Shi L., Yao Y.D., Jiang Q.Q., Li X.F., Tang L.H., Zheng B., Yuen K.Y., Smith D.K., Song E.W. and Huang J., Explicit hypoxia targeting with tumor suppression by creating an "obligate" anaerobic Salmonella Typhimurium strain , Scientific Reports . 2012, 2: 436.

Zhu H., Li L., Zeng Y., Zhou J., Zheng Z., Chen R., Zheng R., Duan L., Yip C.H., Huang K., Lam T.Y., Wang J., Chen H., Webster R.G., Webby R., Peiris J.S.M., Smith D.K. and Guan Y., Pandemic H1N1/2009 virus in swine: prevalence and genesis of reassortants with the potential to infect humans., 4th International Influenza Conference: Influenza2011 Zoonotic Influenza and Human Health. 2011.

Researcher : Smith GJ

Project Title:	Research into the ecology, evolution and population genetics of influenza A (H5N1) virus
Investigator(s):	Smith GJ
Department:	Microbiology
Source(s) of Funding:	National Institutes of Health, US Department of Health and Human Services - General Award
Start Date:	05/2007

Project Title:	Outstanding Young Researcher Award 2008-2009
Investigator(s):	Smith GJ
Department:	Microbiology
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	12/2009

List of Research Outputs

Lessler J., Cummings D.A.T., Read J.M., Wang S., Zhu H., Smith G.J., Guan Y., Jiang C. and Riley S., Location-specific patterns of exposure to recent pre-pandemic strains of influenza A in southern China, Nat Commun. 2011, 2:423: doi:10.1038/ncomms1432.

Researcher : Song W

List of Research Outputs

Wu W.L., Lau S.Y., Chen Y., Wang G., Mok B.W.Y., Wen X., Wang P., Song W., Lin T., Chan K.H., Yuen K.Y. and Chen H., 2008-2009 H1N1 influenza virus exhibits reduced susceptibility to antibody inhibition: implications for the prevalence of oseltamivir resistant variant viruses, Antiviral Research. . 2011, 93: 144-53.

Researcher : Sze KH

Project Title:	XXIInd International Conference on Magnetic Resonance in Biological Systems (ICMRBS 2006) Backbone Dynamics and Solution Structure of a Thermophilic Acylphosphatase from Pyrococcus Horikoshii by NMR Spectroscopy
Investigator(s):	Sze KH
Department:	Chemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2006

Project Title:	Structure-function study of XIAP-Associated Factor 1 (XAF1) structure determinations of XAF1 and its complex with X-Linked Inhibitor of Apoptosis Protein (XIAP) by multi-dimensional NMR spectroscopy
Investigator(s):	Sze KH, Wong BCY
Department:	Chemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2008
Completion Date:	04/2012

Project Title:	Structure-function study of ubiquitin C-terminal hydrolase L1 (UCH-L1) by NMR Spectroscopy Insights into structure changes induced by mutations associated with the risk of Parkinsons disease'
Investigator(s):	Sze KH
Department:	Chemistry
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2009

Project Title:	XXIVth International Conference on Magnetic Resonance in Biological Systems Solution structure of ubiquitin-associated domain of X-linked inhibitor of apoptosis protein and Characterization of its interactions with Ubiquitin and XAF1
Investigator(s):	Sze KH
Department:	Chemistry
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2010

Project Title:	Investigation of the binding of cell wall proteins of Penicillium marneffei and Aspergillus fumigates with proinflammatory lipid signaling molecules: A mechanism of pathogen’s evasion of host defense?
Investigator(s):	Sze KH, Yuen KY, Kao RYT, Woo PCY
Department:	Microbiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2012

List of Research Outputs

Ke Z.H., Chow H.F., Chan M.C., Liu Z.F. and Sze K.H., Head-to-Tail dimerization and organogelating properties of click peptidomimetics, Organic Letters. 2011, 14: 394-397.

Lee K.M., Wu W.H., Chiu Y.H., Sze K.H., Sze K.H., Shaw P.C. and Wong K.B., Solution structure of the dimerization domain of the eurkaryotic stalk P1/P2 complex reveals the structural organization of the eukaryotic stalk, Croucher Advanced Study Institute - Structure-Based Sreening and Design of Ligands for Protein Targets, December 12-15, 2011, CUHK. 2011, Abstract, A01.

Lo K.C., Lo K.C., Zhu G., Sze K.H. and Sze K.H., Study on the interaction between DNA-binding domain (DBD) of human androgen receptor (AR) and SWIRM domain of lysine-specific demethylase 1 (LSD1), Croucher Advanced Study Institute - Structure-Based Sreening and Design of Ligands for Protein Targets, December 12-15, 2011, CUHK . 2011, Abstract, A09.

So L.C., Liu C.C., Chan M.C.W., Lo J.C.Y., Sze K.H., Sze K.H. and Zhu N., Scalar coupling across [C-H^...F-C] interactions in (s-Aryl)-chelating post-metallocenes, Chemistry - A European Journal. 2012, 18: 565-573.

Sze K.H., Wu Q.L., Tse H.S. and Zhu G., Dynamic Nuclear Polarization: New Methodology and Applications, Topics in Current Chemistry. Berlin Heidelberg, Springer-Verlag, 2011, 326: 215-242.

Sze K.H., Sze K.H., Tse H.S. and Hu H.Y., Structure-function study of ubiquitin c-terminal hydrolase L1 (UCH-L1) by NMR spectroscopy - insights into UCH-L1 mutation's association with the risk of parkinson's disease, Joint Annual Scientific Meeting of the Hong Kong Society of Neurosciences and the Biophysical Society of Hong Kong, June 14-15, 2012, Hong Kong. 2012, Abstract, P72, p.79.

Tse M.K., Tse M.K., Hui S.K., Yang Y.H., Yin S.T., Hu H.Y., Zou B., Wong B.C.Y., Sze K.H. and Sze K.H., Structural analysis of the UBA domain of x-linked inhibitor of apoptosis protein reveals different surfaces for ubiquitin-binding and self-association, PLoS one. 2011, 6: e28511 (1-14).

Wu W.H., NG Y.M., Mak A.N.S., Sze K.H., Sze K.H., Au S.W.M., Wong K.B. and Shaw P.C., Interaction between maize ribosome-inactivating protein and ribosomes, Croucher Advanced Study Institute - Structure-Based Sreening and Design of Ligands for Protein Targets, December 12-15, 2011, CUHK . 2011, Abstract, A11.

Yang Y.H., Ng Y.M., Sze K.H., Sze K.H., Zhang X., Zheng Y.T. and Shaw P.C., Structural characterization and anti-HIV-1 activities of arginine/glutamate-rich polypeptide luffin P1 from the seeds of sponge gourd (Luffa Cylindrica), Croucher Advanced Study Institute - Structure-Based Sreening and Design of Ligands for Protein Targets, December 12-15, 2011, CUHK . 2011, Abstract, A19.

Researcher : Tai JWM

List of Research Outputs

Cheng V.C.C., Yam W.C., Yau M.C.Y., Siu G.K.H., Wong S.C.Y., Chan J.F.W., To K.K.W., Tse H., Hung I.F.N., Tai J.W.M., Ho P.L. and Yuen K.Y., Epidemiology Of Klebsiella Oxytoca-associated Diarrhea Detected By Simmons Citrate Agar Supplemented With Inositol, Tryptophan, And Bile Salts., J Clin Microbiol. 2012, 50(5):1571-9.

Cheng V.C.C., Yam W.C., Tsang L.L., Yau M.C.Y., Siu G.K.H., Wong S.C.Y., Chan J.F.W., To K.K.W., Tse H., Hung I.F.N., Tai J.W.M., Ho P.L. and Yuen K.Y., Epidemiology of Klebsiella oxytoca-associated diarrhea detected by Simmons citrate agar supplemented with inositol, tryptophan, and bile salts, Journal of Clinical Microbiology. 2012, 50: 1571-9.

Researcher : Tan Z

List of Research Outputs

Kang Y., Wu Z., Lau T., Lu X., Liu L., Cheung K.L.A., Tan Z., Ng J., Liang J., Wang H., Li S., Zheng B., Li B., Chen L. and Chen Z., CCR5 Antagonist TD-0680 Uses a Novel Mechanism for Enhanced Potency against HIV-1 Entry, Cell-mediated Infection, and a Resistant Variant, JBC. JBC, 2012, 287: 16499.

Researcher : Tang LLS

List of Research Outputs

Chan W.Y., Kang S.R., Yen H., Li C.L., Tang L.L.S., Yu C.L., Yuen K.M., Chan W.W., Wong D.D.Y., Lai W.W.K., Kwong D.L.W., Sihoe A.D.L., Poon L.L.M., Guan Y., Nicholls J.M., Peiris J.S.M. and Chan M.C.W., Tissue tropism of swine influenza viruses and reassortants in ex vivo cultures of the human respiratory tract and conjunctiva., J Virol. 2011, 85(22): 11581-7.

Researcher : Teng LL

Project Title:	Usefulness of full sequence and 5' end 527-bp 16S ribosomal RNA gene sequencing for identification of medically important aerobic Gram-positive cocci
Investigator(s):	Teng LL, Woo PCY, Lau SKP, Yuen KY
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	09/2006

Project Title:	Biosicence for the 21st Century: Emerging Frontiers and Evolving Concepts Automated Identification of Medically Important Bacteria by 16S rRNA Gene Sequencing Using a Novel Comprehensive Database
Investigator(s):	Teng LL
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2011
Completion Date:	07/2011

Project Title:	Automated identification of medically important bacteria by 16S rRNA sequencing using a novel comprehensive database 16SpathDB
Investigator(s):	Teng LL, Woo PCY, Lau SKP
Department:	Microbiology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Mini Grants
Start Date:	09/2011

Project Title:	Usefulness of full sequence and 5’ end 527-bp 16S ribosomal RNA gene sequencing for identification of medically important aerobic Gram-negative bacteria
Investigator(s):	Teng LL, Woo PCY, Lau SKP
Department:	Microbiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	09/2011
Completion Date:	08/2012

List of Research Outputs

Chan J.F.W., Woo P.C.Y., Teng L.L., Lau S.K.P., Leung S.S.M., Tam F.C.C. and Yuen K.Y., Primary infective spondylodiscitis caused by Lactococcus garvieae and a review of human L. garvieae infections, Infection. 2011, 39: 259-264.

Lau S.K.P., Woo P.C.Y., Yeung C., Teng L.L., Wu Y., Bai R., Fan Y.Y., Chan K.H. and Yuen K.Y., Identification and characterization of bocaviruses in cats and dogs revealed a novel feline bocavirus and a novel genetic group of canine bocavirus, Journal of General Virology. 2012, 93: 1573-1582.

Lau S.K.P., Fan Y.Y., Wong G.K.M., Teng L.L., Sze K.H., Tse H., Yuen K.Y. and Woo P.C.Y., Transport genes and chemotaxis in Laribacter hongkongensis: a genome-wide analysis, Cell and Bioscience. 2011, 1: 28.

Teng L.L., Yeung M.Y., Yue G., Au-Yeung R.K.H., Yeung E.Y.H., Fung A.M.Y., Tse H., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., In silico analysis of 16S rRNA gene sequencing based methods for identification of medically important aerobic Gram-negative bacteria, Journal of Medical Microbiology. 2011, 2011, 60: 1281-1286.

Tse H., Tsoi H.W., Teng L.L., Chen X.C., Liu H., Zhou B., Zheng B., Woo P.C.Y., Lau S.K.P. and Yuen K.Y., Discovery and genomic characterization of a novel ovine partetravirus and a new genotype of bovine partetravirus, PLoS One. 2011, 6: e25619.

Woo P.C.Y., Lau S.K.P., Bai R., Teng L.L., Lee P., Martelli P., Hui S.W. and Yuen K.Y., Complete genome sequence of a novel picobirnavirus, otarine picobirnavirus, discovered in California sea lions, Journal of Virology. 2012, 86: 6377-6378.

Woo P.C.Y., Lau S.K.P., Lam S.F., Lau C.Y., Tsang K.L., Lau J.H.N., Bai R., Teng L.L., Tsang C.C.C., Wang M., Zheng B., Chan K.H. and Yuen K.Y., Discovery of seven novel mammalian and avian coronaviruses in Deltacoronavirus supports bat coronaviruses as the gene source of Alphacoronavirus and Betacoronavirus and avian coronaviruses as the gene source of Gammacoronavirus and Deltacoronavirus, Journal of Virology. 2012, 86: 3995-4008.

Woo P.C.Y., Lau S.K.P., Choi K.Y., Huang Y., Teng L.L., Tsoi H.W., Tse H., Yeung M.L., Chan K.H., Jin D. and Yuen K.Y., Natural occurrence and characterization of two IRES elements in a novel virus, canine picodicistrovirus, in the picornavirus-like superfamily, Journal of Virology. 2011, 86: 2797-2808.

Researcher : To KKW

Project Title:	Rapid detection of macrolide resistance amony Mycoplasma pneumoniae in Queen Mary Hospital
Investigator(s):	To KKW, Ho PL, Chan KH, Hung IFN, Chiu SSS
Department:	Microbiology
Source(s) of Funding:	Queen Mary Hospital Charitable Trust - Training and Research Assistance Scheme
Start Date:	07/2011

Project Title:	IDSA 49th annual meeting Age-specific Incidence Rate in Severe or Symptomatic Infection due to Pandemic H1N1 2009 Influenza Virus
Investigator(s):	To KKW
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	10/2011
Completion Date:	10/2011

List of Research Outputs

Chan J.F.W., Lau S.K.P., Curreem S.O.T., To K.K.W., Leung S.S.M., Cheng V.C.C., Yuen K.Y. and Woo P.C.Y., First report of spontaneous intrapartum Atopobium vaginae bacteremia, Journal of Clinical Microbiology. 2012, 50: 2525-2528.

Cheng V.C.C., Yam W.C., Yau M.C.Y., Siu G.K.H., Wong S.C.Y., Chan J.F.W., To K.K.W., Tse H., Hung I.F.N., Tai J.W.M., Ho P.L. and Yuen K.Y., Epidemiology Of Klebsiella Oxytoca-associated Diarrhea Detected By Simmons Citrate Agar Supplemented With Inositol, Tryptophan, And Bile Salts., J Clin Microbiol. 2012, 50(5):1571-9.

Cheng V.C.C., Yam W.C., Tsang L.L., Yau M.C.Y., Siu G.K.H., Wong S.C.Y., Chan J.F.W., To K.K.W., Tse H., Hung I.F.N., Tai J.W.M., Ho P.L. and Yuen K.Y., Epidemiology of Klebsiella oxytoca-associated diarrhea detected by Simmons citrate agar supplemented with inositol, tryptophan, and bile salts, Journal of Clinical Microbiology. 2012, 50: 1571-9.

Ho P.L., Yeung M.K., Lo W.U., Tse H., Li Z., Lai E.L.Y., Chow K.H., To K.K.W. and Yam W.C., Predominance of pHK01-like incompatibility group FII plasmids encoding CTX-M-14 among extended-spectrum beta-lactamase-producing Escherichia coli in Hong Kong, 1996-2008, Diagnostic Microbiology and Infectious Diseases. 2012, 73: 182-186.

Hung I.F.N. and To K.K.W., Quantitative And Qualitative Analysis Of Antibody Response After Dose Sparing Intradermal 2009 H1n1 Vaccination, Vaccine. 2011, 2707-8.

Lei T., Siu K.L., Koh K.H., Chan K.H., Hung I.F.N., To K.K.W. and Yuen K.Y., Anti-ganglioside Antibodies Were Not Detected In Human Subjects Infected With Or Vaccinated Against 2009 Pandemic Influenza A (h1n1) Virus., Vaccine. 2012, 30(16):2605-10.

Lei T., Siu K.L., Kok K.H., Chan K.H., Chan E.Y.T., Hung I.F.N., To K.K.W., Li P.C.K., Zhou J., Zheng B., Yuen K.Y., Wang M. and Jin D., Anti-ganglioside antibodies were not detected in human subjects infected with or vaccinated against 2009 pandemic influenza A (H1N1) virus., Vaccine. 2012, 30: 2605-2610.

To K.K.W., Age-specific Incidence Rate in Severe or Symptomatic Infection due to Pandemic H1N1 2009 Influenza Virus , IDSA 49th Annual Meeting . 2011.

To K.K.W., Colistin – the last resort for MDRO, Centre for Health Protection Infection Control Forum. 2012.

To K.K.W., Detection of Pneumocystis jirovecii in adult patients with acute and chronic respiratory tract infections, 22nd European Congress of Clinical Microbiology and Infectious Diseases. 2012.

To K.K.W., Scarlet fever and Group A Streptococcus, Hong Kong Association of Medical Laboratories . 2011.

Tse H., To K.K.W., Wen X., Chen H., Chan K.H., Tsoi H.W., Li I.W.S. and Yuen K.Y., Clinical and virological factors associated with viremia in pandemic influenza A/H1N1/2009 virus infection, PLoS One. 2011, 6: e22534.

Wong R.L.M., Yu W.H., To K.K.W., Lai W.W.K. and Wong Y.H.I., Spectrum of microbial keratitis in Hong Kong - A seven-year local series, The 27th Asia-Pacific Academy of Ophthalmology Congress. 2012.

Yap Y.H.D., To K.K.W., Yip T.P.S., Lui S.L., Chan D.T.M., Lai K.N. and Lo W.K., Streptococcus bovis peritonitis complicating peritoneal dialysis - a review of 10 years' experience, Peritoneal Dialysis International. 2012, 32: 55-9.

Zhang J., To K.K.W., Tse H., Chan K.H., Hung I.F.N. and Yuen K.Y., High Incidence Of Severe Influenza Among Individuals Over 50 Years Of Age., Clin Vaccine Immunol . 2011, 18(11):1918-24.

Researcher : Tsang KL

List of Research Outputs

Lau S.K.P., Woo P.C.Y., Yip C.Y., Fan Y.Y., Huang Y., Wang M., Guo R., Lam S.F., Tsang K.L., Lai K.Y., Chan K.H., Che X.Y., Zheng B. and Yuen K.Y., Isolation and characterization of a novel Betacoronavirus subgroup A coronavirus, rabbit coronavirus HKU14, from domestic rabbits, Journal of Virology. 2012, 86: 5481-5496.

Lau S.K.P., Lee P., Tsang K.L., Yip C.Y., Tse H., Lee R.A., So L.Y., Lau Y.L., Chan K.H., Woo P.C.Y. and Yuen K.Y., Molecular epidemiology of human coronavirus OC43 reveals evolution of different genotypes over time and recent emergence of a novel genotype due to natural recombination., Journal of Virology. 2011, 85: 11325-11337.

Woo P.C.Y., Lau S.K.P., Lam S.F., Lau C.Y., Tsang K.L., Lau J.H.N., Bai R., Teng L.L., Tsang C.C.C., Wang M., Zheng B., Chan K.H. and Yuen K.Y., Discovery of seven novel mammalian and avian coronaviruses in Deltacoronavirus supports bat coronaviruses as the gene source of Alphacoronavirus and Betacoronavirus and avian coronaviruses as the gene source of Gammacoronavirus and Deltacoronavirus, Journal of Virology. 2012, 86: 3995-4008.

Researcher : Tse H

Project Title:	Purification and characterization of cytotoxins produced by the human pathogen Staphylococcus lugdunensis
Investigator(s):	Tse H, Lau SKP, Woo PCY, Yuen KY
Department:	Microbiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2011

Project Title:	Phylogenetic reconstruction of coronavirus evolution under non-homogeneous, non-stationary models
Investigator(s):	Tse H, Lau SKP, Yuen KY, Woo PCY
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	04/2012

List of Research Outputs

Cheng V.C.C., Yam W.C., Yau M.C.Y., Siu G.K.H., Wong S.C.Y., Chan J.F.W., To K.K.W., Tse H., Hung I.F.N., Tai J.W.M., Ho P.L. and Yuen K.Y., Epidemiology Of Klebsiella Oxytoca-associated Diarrhea Detected By Simmons Citrate Agar Supplemented With Inositol, Tryptophan, And Bile Salts., J Clin Microbiol. 2012, 50(5):1571-9.

Cheng V.C.C., Yam W.C., Tsang L.L., Yau M.C.Y., Siu G.K.H., Wong S.C.Y., Chan J.F.W., To K.K.W., Tse H., Hung I.F.N., Tai J.W.M., Ho P.L. and Yuen K.Y., Epidemiology of Klebsiella oxytoca-associated diarrhea detected by Simmons citrate agar supplemented with inositol, tryptophan, and bile salts, Journal of Clinical Microbiology. 2012, 50: 1571-9.

Ho P.L., Yeung M.K., Lo W.U., Tse H., Li Z., Lai E.L.Y., Chow K.H., To K.K.W. and Yam W.C., Predominance of pHK01-like incompatibility group FII plasmids encoding CTX-M-14 among extended-spectrum beta-lactamase-producing Escherichia coli in Hong Kong, 1996-2008, Diagnostic Microbiology and Infectious Diseases. 2012, 73: 182-186.

Lau S.K.P., Lee P., Tsang K.L., Yip C.Y., Tse H., Lee R.A., So L.Y., Lau Y.L., Chan K.H., Woo P.C.Y. and Yuen K.Y., Molecular epidemiology of human coronavirus OC43 reveals evolution of different genotypes over time and recent emergence of a novel genotype due to natural recombination., Journal of Virology. 2011, 85: 11325-11337.

Lau S.K.P., Fan Y.Y., Wong G.K.M., Teng L.L., Sze K.H., Tse H., Yuen K.Y. and Woo P.C.Y., Transport genes and chemotaxis in Laribacter hongkongensis: a genome-wide analysis, Cell and Bioscience. 2011, 1: 28.

Teng L.L., Yeung M.Y., Yue G., Au-Yeung R.K.H., Yeung E.Y.H., Fung A.M.Y., Tse H., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., In silico analysis of 16S rRNA gene sequencing based methods for identification of medically important aerobic Gram-negative bacteria, Journal of Medical Microbiology. 2011, 2011, 60: 1281-1286.

Tse H., To K.K.W., Wen X., Chen H., Chan K.H., Tsoi H.W., Li I.W.S. and Yuen K.Y., Clinical and virological factors associated with viremia in pandemic influenza A/H1N1/2009 virus infection, PLoS One. 2011, 6: e22534.

Tse H., Lau S.K.P., Chan W.M., Choi K.Y., Woo P.C.Y. and Yuen K.Y., Complete genome sequences of novel canine noroviruses in Hong Kong, Journal of Virology. 2012, 86: 9531-9532.

Tse H., Conference Papers in Microbiology. Hindawi, 2012.

Tse H., Chan W.M., Li K.S.M., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Discovery and genomic characterization of a novel bat sapovirus with unusual genomic features and phylogenetic position, PLoS One. 2012, 7: e34987.

Tse H., Tsoi H.W., Teng L.L., Chen X.C., Liu H., Zhou B., Zheng B., Woo P.C.Y., Lau S.K.P. and Yuen K.Y., Discovery and genomic characterization of a novel ovine partetravirus and a new genotype of bovine partetravirus, PLoS One. 2011, 6: e25619.

Tse H., Chan W.M., Tsoi H.W., Fan Y.Y., Lau C.Y., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Rediscovery and genomic characterization of bovine astroviruses, Journal of General Virology. 2011, 2011, 92: 1888-1898.

Tse H., Kao R.Y.T., Wu W.L., Lim W.W., Chen H., Yeung M.Y., Woo P.C.Y., Sze K.H. and Yuen K.Y., Structural basis and sequence co-evolution analysis of the hemagglutinin protein of the pandemic influenza A/H1N1 (2009) virus, Experimental Biology and Medicine. 2011, 236: 915-25.

Woo P.C.Y., Lau S.K.P., Liu B., Cai J.J., Chong T.K., Tse H., Kao R.Y.T., Chan C.M., Chow W.N. and Yuen K.Y., Draft genome sequence of Penicillium marneffei strain PM1, Eukaryotic Cell. 2011, 10: 1740-1741.

Woo P.C.Y., Lau S.K.P., Choi K.Y., Huang Y., Teng L.L., Tsoi H.W., Tse H., Yeung M.L., Chan K.H., Jin D. and Yuen K.Y., Natural occurrence and characterization of two IRES elements in a novel virus, canine picodicistrovirus, in the picornavirus-like superfamily, Journal of Virology. 2011, 86: 2797-2808.

Zhang J., To K.K.W., Tse H., Chan K.H., Hung I.F.N. and Yuen K.Y., High Incidence Of Severe Influenza Among Individuals Over 50 Years Of Age., Clin Vaccine Immunol . 2011, 18(11):1918-24.

Researcher : Tse MK

List of Research Outputs

Tse M.K., Tse M.K., Hui S.K., Yang Y.H., Yin S.T., Hu H.Y., Zou B., Wong B.C.Y., Sze K.H. and Sze K.H., Structural analysis of the UBA domain of x-linked inhibitor of apoptosis protein reveals different surfaces for ubiquitin-binding and self-association, PLoS one. 2011, 6: e28511 (1-14).

Researcher : Tsoi HW

List of Research Outputs

Tse H., To K.K.W., Wen X., Chen H., Chan K.H., Tsoi H.W., Li I.W.S. and Yuen K.Y., Clinical and virological factors associated with viremia in pandemic influenza A/H1N1/2009 virus infection, PLoS One. 2011, 6: e22534.

Tse H., Tsoi H.W., Teng L.L., Chen X.C., Liu H., Zhou B., Zheng B., Woo P.C.Y., Lau S.K.P. and Yuen K.Y., Discovery and genomic characterization of a novel ovine partetravirus and a new genotype of bovine partetravirus, PLoS One. 2011, 6: e25619.

Tse H., Chan W.M., Tsoi H.W., Fan Y.Y., Lau C.Y., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Rediscovery and genomic characterization of bovine astroviruses, Journal of General Virology. 2011, 2011, 92: 1888-1898.

Woo P.C.Y., Lau S.K.P., Choi K.Y., Huang Y., Teng L.L., Tsoi H.W., Tse H., Yeung M.L., Chan K.H., Jin D. and Yuen K.Y., Natural occurrence and characterization of two IRES elements in a novel virus, canine picodicistrovirus, in the picornavirus-like superfamily, Journal of Virology. 2011, 86: 2797-2808.

Researcher : Wang J

List of Research Outputs

Lam T.Y., Zhu H., Wang J., Smith D.K., Holmes E.C., Webster R.G., Webby R., Peiris J.S.M. and Guan Y., Reassortment Events Among Swine Influenza A Viruses in China: Implications for the Origin of the 2009 Influenza Pandemic, J Virol. 2011, 85(19): 10279-85.

Zhu H., Li L., Zeng Y., Zhou J., Zheng Z., Chen R., Zheng R., Duan L., Yip C.H., Huang K., Lam T.Y., Wang J., Chen H., Webster R.G., Webby R., Peiris J.S.M., Smith D.K. and Guan Y., Pandemic H1N1/2009 virus in swine: prevalence and genesis of reassortants with the potential to infect humans., 4th International Influenza Conference: Influenza2011 Zoonotic Influenza and Human Health. 2011.

Researcher : Wang P

List of Research Outputs

Wu W.L., Lau S.Y., Chen Y., Wang G., Mok B.W.Y., Wen X., Wang P., Song W., Lin T., Chan K.H., Yuen K.Y. and Chen H., 2008-2009 H1N1 influenza virus exhibits reduced susceptibility to antibody inhibition: implications for the prevalence of oseltamivir resistant variant viruses, Antiviral Research. . 2011, 93: 144-53.

Researcher : Wen X

List of Research Outputs

Tse H., To K.K.W., Wen X., Chen H., Chan K.H., Tsoi H.W., Li I.W.S. and Yuen K.Y., Clinical and virological factors associated with viremia in pandemic influenza A/H1N1/2009 virus infection, PLoS One. 2011, 6: e22534.

Wu W.L., Lau S.Y., Chen Y., Wang G., Mok B.W.Y., Wen X., Wang P., Song W., Lin T., Chan K.H., Yuen K.Y. and Chen H., 2008-2009 H1N1 influenza virus exhibits reduced susceptibility to antibody inhibition: implications for the prevalence of oseltamivir resistant variant viruses, Antiviral Research. . 2011, 93: 144-53.

Researcher : Wong BHL

List of Research Outputs

Woo P.C.Y., Lau S.K.P., Wong B.H.L., Wong Y.P., Poon W.S.R. and Yuen K.Y., Complete genome sequence of a novel paramyxovirus, Tailam virus, discovered in Sikkim rats, Journal of Virology. 2011, 85: 13473-13474.

Woo P.C.Y., Lau S.K.P., Wong B.H.L., Fan Y.Y., Wong Y.P., Zhang J., Wu Y., Choi K.Y., Li K.S.M., Hui J., Wang M., Zheng B., Chan K.H. and Yuen K.Y., Feline morbillivirus, a previously undescribed paramyxovirus associated with tubulointerstitial nephritis in domestic cats, Proceedings of the National Academy of Sciences of the USA. 2012, 109: 5435-5440.

Woo P.C.Y., Lau S.K.P., Wong B.H.L., Wu Y., Lam S.F. and Yuen K.Y., Novel variant of Beilong paramyxovirus in rats, China, Emerging Infectious Diseases. 2012, 18: 1022-1024.

Researcher : Wong DDY

List of Research Outputs

Yen H., Liang C.-.H., Wu C.-.Y., Forrest H., Ferguson A., Choy K.T., Jones J., Wong D.D.Y., Cheung P.H.P., Hsu C.-.H., Li O.T.W., Yuen K.M., Chan W.Y., Poon L.L.M., Chan M.C.W., Nicholls J.M., Krauss S., Wong C.-.H., Guan Y., Webster R.G., Webby R. and Peiris J.S.M., Hemagglutinin-neuraminidase balance confers respiratory-droplet transmissibility of the pandemic H1N1 influenza virus in ferrets, Proceedings of National Academic Science (USA). 2011, 108: 14264-14269.

Researcher : Wong GKM

List of Research Outputs

Lau S.K.P., Fan Y.Y., Wong G.K.M., Teng L.L., Sze K.H., Tse H., Yuen K.Y. and Woo P.C.Y., Transport genes and chemotaxis in Laribacter hongkongensis: a genome-wide analysis, Cell and Bioscience. 2011, 1: 28.

Researcher : Wong LP

List of Research Outputs

Ng E.K.O., Leung P.H.C., Shin V.Y., Wong L.P., Ma E.S.K., Jin H.C., Chu K.M. and Kwong A., Quantitative analysis and diagnostic significance of methylated SLC19A3 DNA in the plasma of breast and gastric cancer patients, PLoS One. 2011, 6(7): e22233.

Researcher : Wong SCY

List of Research Outputs

Cheng V.C.C., Yam W.C., Yau M.C.Y., Siu G.K.H., Wong S.C.Y., Chan J.F.W., To K.K.W., Tse H., Hung I.F.N., Tai J.W.M., Ho P.L. and Yuen K.Y., Epidemiology Of Klebsiella Oxytoca-associated Diarrhea Detected By Simmons Citrate Agar Supplemented With Inositol, Tryptophan, And Bile Salts., J Clin Microbiol. 2012, 50(5):1571-9.

Cheng V.C.C., Yam W.C., Tsang L.L., Yau M.C.Y., Siu G.K.H., Wong S.C.Y., Chan J.F.W., To K.K.W., Tse H., Hung I.F.N., Tai J.W.M., Ho P.L. and Yuen K.Y., Epidemiology of Klebsiella oxytoca-associated diarrhea detected by Simmons citrate agar supplemented with inositol, tryptophan, and bile salts, Journal of Clinical Microbiology. 2012, 50: 1571-9.

Researcher : Wong SSY

Project Title:	Molecular characterization of streptococcus bovis bacteraemia
Investigator(s):	Wong SSY, Yuen KY, Woo PCY
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Project Title:	Characterization of bacterial isolates with ambiguous biochemical profiles recovered from patients with clinically significant bacteremia by 16S rRNA gene sequencing, the state-of-the-art molecular technique for bacterial identification
Investigator(s):	Wong SSY, Woo PCY, Lau SKP
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

List of Research Outputs

Lau S.K.P., Fan Y.Y., Lo H.W., Ng R.H.Y., Wong S.S.Y., Li W.S., Wu A.K.L., Ng K.H.L., Tseung S., Lee R.A., Fung K.S.C., Que T.L., Yuen K.Y. and Woo P.C.Y., High mortality associated with Catabacter hongkongensis bacteremia, Journal of Clinical Microbiology. 2012, 50: 2239-2243.

Researcher : Wong YP

List of Research Outputs

Woo P.C.Y., Lau S.K.P., Wong B.H.L., Wong Y.P., Poon W.S.R. and Yuen K.Y., Complete genome sequence of a novel paramyxovirus, Tailam virus, discovered in Sikkim rats, Journal of Virology. 2011, 85: 13473-13474.

Woo P.C.Y., Lau S.K.P., Wong B.H.L., Fan Y.Y., Wong Y.P., Zhang J., Wu Y., Choi K.Y., Li K.S.M., Hui J., Wang M., Zheng B., Chan K.H. and Yuen K.Y., Feline morbillivirus, a previously undescribed paramyxovirus associated with tubulointerstitial nephritis in domestic cats, Proceedings of the National Academy of Sciences of the USA. 2012, 109: 5435-5440.

Researcher : Woo P.C.Y.

Project Title:	Resequencing microarray for detection of viruses in patients with conjunctivitis
Investigator(s):	Woo PCY, Lau SKP, Yuen KY
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	09/2009
Completion Date:	08/2011

Project Title:	Understanding interclass jumping between mammalian and avian coronaviruses
Investigator(s):	Woo PCY, Lau SKP, Yuen KY
Department:	Microbiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2010
Completion Date:	12/2011

Project Title:	A novel pan-genomic analysis approach to select targets for multiplex PCR identification and detection of Burkholderia pseudomallei, Burkholderia thailandensis and Burkholderia cepacia complex species: a proof-of-concept study
Investigator(s):	Woo PCY, Lau SKP, Yuen KY
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	09/2010

Project Title:	Molecular evolution and interspecies jumping in picornaviruses
Investigator(s):	Woo PCY, Lau SKP, Yuen KY
Department:	Microbiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2011

Project Title:	Significance of Lichtheimia hongkongensis as a cause of mucormycosis
Investigator(s):	Woo PCY, Lau SKP, Yuen KY
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2012

List of Research Outputs

Researcher : Woo PCY

Project Title:	Resequencing microarray for detection of viruses in patients with conjunctivitis
Investigator(s):	Woo PCY, Lau SKP, Yuen KY
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	09/2009
Completion Date:	08/2011

Project Title:	Understanding interclass jumping between mammalian and avian coronaviruses
Investigator(s):	Woo PCY, Lau SKP, Yuen KY
Department:	Microbiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2010
Completion Date:	12/2011

Project Title:	A novel pan-genomic analysis approach to select targets for multiplex PCR identification and detection of Burkholderia pseudomallei, Burkholderia thailandensis and Burkholderia cepacia complex species: a proof-of-concept study
Investigator(s):	Woo PCY, Lau SKP, Yuen KY
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	09/2010

Project Title:	Molecular evolution and interspecies jumping in picornaviruses
Investigator(s):	Woo PCY, Lau SKP, Yuen KY
Department:	Microbiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2011

Project Title:	Significance of Lichtheimia hongkongensis as a cause of mucormycosis
Investigator(s):	Woo PCY, Lau SKP, Yuen KY
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2012

List of Research Outputs

Chan J.F.W., Lau S.K.P., Curreem S.O.T., To K.K.W., Leung S.S.M., Cheng V.C.C., Yuen K.Y. and Woo P.C.Y., First report of spontaneous intrapartum Atopobium vaginae bacteremia, Journal of Clinical Microbiology. 2012, 50: 2525-2528.

Chan J.F.W., Woo P.C.Y., Teng L.L., Lau S.K.P., Leung S.S.M., Tam F.C.C. and Yuen K.Y., Primary infective spondylodiscitis caused by Lactococcus garvieae and a review of human L. garvieae infections, Infection. 2011, 39: 259-264.

Chan T.C., Hung I.F.N., Woo P.C.Y. and Chu L.W., Efficacy Of Dual Vaccination Of Pandemic H1n1 2009 Influenza And Seasonal Influenza On Institutionalized Elderly: A One-year Prospective Cohort Study., Vaccine. 2011, 29(44):7773-8.

Chan T.C., Hung I.F.N., Luk J.K.H., Woo P.C.Y. and Chu L.W., Prevention Of Mortality And Pneumonia Among Nursing Home Older Adults By Dual Pneumococcal And Seasonal Influenza Vaccination During A Pandemic Caused By Novel Pandemic Influenza A (h1n1)., J Am Med Dir Assoc. 2012.

Curreem S.O.T., Watt R.M., Lau S.K.P. and Woo P.C.Y., Two-dimensional gel electrophoresis in bacterial proteomics, Protein & Cell. 2012, 3: 346-363.

Ho C.C., Wu A.K.L., Tse C.W.S., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Automated pangenomic analysis in target selection for PCR detection and identification of bacteria by use of ssGeneFinder Webserver and its application to Salmonella enterica serovar Typhi, Journal of Clinical Microbiology. 2012, 50: 1905-1911.

Ho C.C., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Rapid identification and validation of specific molecular targets for detection of Escherichia coli O104:H4 outbreak strain using high-throughput sequencing data from nine genomes, Journal of Clinical Microbiology. 2011, 49: 3714-3716.

Lau S.K.P., Woo P.C.Y., Lai K.Y., Huang Y., Yip C.Y., Shek C.T., Lee P., Lam S.F., Chan K.H. and Yuen K.Y., Complete genome analysis of three novel picornaviruses from diverse bat species, Journal of Virology. 2011, 85: 8819-8828.

Lau S.K.P., Curreem S.O.T., Ngan H.Y., Yeung C.K., Yuen K.Y. and Woo P.C.Y., First report of disseminated Mycobacterium skin infections in two liver transplant recipients and rapid diagnosis by hsp65 gene sequencing, Journal of Clinical Microbiology. 2011, 49: 3733-3737.

Lau S.K.P., Fan Y.Y., Lo H.W., Ng R.H.Y., Wong S.S.Y., Li W.S., Wu A.K.L., Ng K.H.L., Tseung S., Lee R.A., Fung K.S.C., Que T.L., Yuen K.Y. and Woo P.C.Y., High mortality associated with Catabacter hongkongensis bacteremia, Journal of Clinical Microbiology. 2012, 50: 2239-2243.

Lau S.K.P., Woo P.C.Y., Yeung C., Teng L.L., Wu Y., Bai R., Fan Y.Y., Chan K.H. and Yuen K.Y., Identification and characterization of bocaviruses in cats and dogs revealed a novel feline bocavirus and a novel genetic group of canine bocavirus, Journal of General Virology. 2012, 93: 1573-1582.

Lau S.K.P., Woo P.C.Y., Yip C.Y., Choi K.Y., Wu Y., Bai R., Fan Y.Y., Lai K.Y., Chan K.H. and Yuen K.Y., Identification of a novel feline picornavirus from the domestic cat, Journal of Virology . 2011, 86: 395-405.

Lau S.K.P., Woo P.C.Y., Yip C.Y., Fan Y.Y., Huang Y., Wang M., Guo R., Lam S.F., Tsang K.L., Lai K.Y., Chan K.H., Che X.Y., Zheng B. and Yuen K.Y., Isolation and characterization of a novel Betacoronavirus subgroup A coronavirus, rabbit coronavirus HKU14, from domestic rabbits, Journal of Virology. 2012, 86: 5481-5496.

Lau S.K.P., Tang B.S.F., Curreem S.O.T., Chan T.M., Martelli P., Tse C.W.S., Wu A.K.L., Yuen K.Y. and Woo P.C.Y., Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry for Rapid Identification of Burkholderia pseudomallei: Importance of Expanding Databases with Pathogens Endemic to Different Localities., Journal of Clinical Microbiology. 2012, 50: 3142-3.

Lau S.K.P., Lee P., Tsang K.L., Yip C.Y., Tse H., Lee R.A., So L.Y., Lau Y.L., Chan K.H., Woo P.C.Y. and Yuen K.Y., Molecular epidemiology of human coronavirus OC43 reveals evolution of different genotypes over time and recent emergence of a novel genotype due to natural recombination., Journal of Virology. 2011, 85: 11325-11337.

Lau S.K.P., Fan Y.Y., Wong G.K.M., Teng L.L., Sze K.H., Tse H., Yuen K.Y. and Woo P.C.Y., Transport genes and chemotaxis in Laribacter hongkongensis: a genome-wide analysis, Cell and Bioscience. 2011, 1: 28.

Teng L.L., Yeung M.Y., Yue G., Au-Yeung R.K.H., Yeung E.Y.H., Fung A.M.Y., Tse H., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., In silico analysis of 16S rRNA gene sequencing based methods for identification of medically important aerobic Gram-negative bacteria, Journal of Medical Microbiology. 2011, 2011, 60: 1281-1286.

Tse H., Lau S.K.P., Chan W.M., Choi K.Y., Woo P.C.Y. and Yuen K.Y., Complete genome sequences of novel canine noroviruses in Hong Kong, Journal of Virology. 2012, 86: 9531-9532.

Tse H., Chan W.M., Li K.S.M., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Discovery and genomic characterization of a novel bat sapovirus with unusual genomic features and phylogenetic position, PLoS One. 2012, 7: e34987.

Tse H., Tsoi H.W., Teng L.L., Chen X.C., Liu H., Zhou B., Zheng B., Woo P.C.Y., Lau S.K.P. and Yuen K.Y., Discovery and genomic characterization of a novel ovine partetravirus and a new genotype of bovine partetravirus, PLoS One. 2011, 6: e25619.

Tse H., Chan W.M., Tsoi H.W., Fan Y.Y., Lau C.Y., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Rediscovery and genomic characterization of bovine astroviruses, Journal of General Virology. 2011, 2011, 92: 1888-1898.

Tse H., Kao R.Y.T., Wu W.L., Lim W.W., Chen H., Yeung M.Y., Woo P.C.Y., Sze K.H. and Yuen K.Y., Structural basis and sequence co-evolution analysis of the hemagglutinin protein of the pandemic influenza A/H1N1 (2009) virus, Experimental Biology and Medicine. 2011, 236: 915-25.

Wang Y.F., Cai J.P., Wang Y.D., Dong H., Hao W., Jiang L.X., Long J., Chan C.M., Woo P.C.Y., Lau S.K.P., Yuen K.Y. and Che X.Y., Immunoassays based on Penicillium marneffei Mp1p derived from Pichia pastoris expression system for diagnosis of penicilliosis, PLoS One. 2011, 6: e28796.

Wong M.Y., Lau S.K.P., Tang S.C.W., Curreem S.O.T., Woo P.C.Y. and Yuen K.Y., First Report of Peritoneal Dialysis-Related Peritonitis Caused by Citrobacter amalonaticus, Peritoneal Dialysis International. 2012, 32: 224-225.

Woo P.C.Y., Leung S.Y., Ngan A.H.Y., Lau S.K.P. and Yuen K.Y., A significant number of reported Absidia corymbifera (Lichtheimia corymbifera) infections are caused by Lictheimia ramosa (syn. Lichtheimia hongkongensis): an emerging cause of mucormycosis, Emerging Microbes & Infections. 2012, 1: e12.

Woo P.C.Y., Lau S.K.P., Wong B.H.L., Wong Y.P., Poon W.S.R. and Yuen K.Y., Complete genome sequence of a novel paramyxovirus, Tailam virus, discovered in Sikkim rats, Journal of Virology. 2011, 85: 13473-13474.

Woo P.C.Y., Lau S.K.P., Bai R., Teng L.L., Lee P., Martelli P., Hui S.W. and Yuen K.Y., Complete genome sequence of a novel picobirnavirus, otarine picobirnavirus, discovered in California sea lions, Journal of Virology. 2012, 86: 6377-6378.

Woo P.C.Y., Coronavirus diversity, phylogeny and interspecies jumping, Asia-Pacific Congress of Medical Virology (Adelaide, Australia) . 2012.

Woo P.C.Y., Coronavirus diversity, phylogeny and interspecies jumping, Society of Chinese Bioscientists in America, the 13 International Symposium (Guangzhou, China) . 2011.

Woo P.C.Y., Lau S.K.P., Lam S.F., Lau C.Y., Tsang K.L., Lau J.H.N., Bai R., Teng L.L., Tsang C.C.C., Wang M., Zheng B., Chan K.H. and Yuen K.Y., Discovery of seven novel mammalian and avian coronaviruses in Deltacoronavirus supports bat coronaviruses as the gene source of Alphacoronavirus and Betacoronavirus and avian coronaviruses as the gene source of Gammacoronavirus and Deltacoronavirus, Journal of Virology. 2012, 86: 3995-4008.

Woo P.C.Y., Lau S.K.P., Liu B., Cai J.J., Chong T.K., Tse H., Kao R.Y.T., Chan C.M., Chow W.N. and Yuen K.Y., Draft genome sequence of Penicillium marneffei strain PM1, Eukaryotic Cell. 2011, 10: 1740-1741.

Woo P.C.Y., Lau S.K.P., Wong B.H.L., Fan Y.Y., Wong Y.P., Zhang J., Wu Y., Choi K.Y., Li K.S.M., Hui J., Wang M., Zheng B., Chan K.H. and Yuen K.Y., Feline morbillivirus, a previously undescribed paramyxovirus associated with tubulointerstitial nephritis in domestic cats, Proceedings of the National Academy of Sciences of the USA. 2012, 109: 5435-5440.

Woo P.C.Y., More and more coronaviruses after the SARS epidemic: human coronavirus HKU1 and other coronaviruses, Fifth Ditan International Conference on Infectious Diseases (Beijing, China). 2011.

Woo P.C.Y., More and more coronaviruses, Chinese Academy of Sciences (Beijing, China). 2011.

Woo P.C.Y., More and more coronaviruses, The International symposium on Emerging Infectious Diseases in Pan Pearl River Delta Region (Guangzhou, China). 2011.

Woo P.C.Y., Lau S.K.P., Choi K.Y., Huang Y., Teng L.L., Tsoi H.W., Tse H., Yeung M.L., Chan K.H., Jin D. and Yuen K.Y., Natural occurrence and characterization of two IRES elements in a novel virus, canine picodicistrovirus, in the picornavirus-like superfamily, Journal of Virology. 2011, 86: 2797-2808.

Woo P.C.Y., Novel human and animal coronaviruses, Workshop on microbiology, pathogenesis and therapies for pandemic threats and emerging infectious diseases (Singapore) . 2011.

Woo P.C.Y., Lau S.K.P., Wong B.H.L., Wu Y., Lam S.F. and Yuen K.Y., Novel variant of Beilong paramyxovirus in rats, China, Emerging Infectious Diseases. 2012, 18: 1022-1024.

Woo P.C.Y., What have we learned from Laribacter hongkongensis so far, The fifth meeting of Tuanshan Hill anti-EID forum (Beijing, China). 2012.

Yang W., Chen W., Wang H., Ho J.W.S., Huang J., Woo P.C.Y., Lau S.K.P., Yuen K.Y., Zhang Q., Zhou W., Bartlam M., Watt R.M. and Rao Z., Structural and functional insight into the mechanism of an alkaline exonuclease from Laribacter hongkongensis, Nucleic Acids Research. 2011, 39(22): 9803-19.

Yip C.Y., Lau S.K.P., Woo P.C.Y., Chan K.H. and Yuen K.Y., Complete genome sequence of a coxsackievirus A22 strain in Hong Kong reveals a natural intratypic recombination event, Journal of Virology . 2011, 85: 12098-12099.

Researcher : Wu WL

Project Title:	Characterization of conserved antigenic epitopes in hemagglutinin (HA) of the pandemic (H1N1) influenza virus with cross subtypes neutralizing monoclonal antibodies
Investigator(s):	Wu WL, Chen H
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	03/2011
Completion Date:	08/2012

List of Research Outputs

Chen Y., Zheng Q., Zeng F., Lau S.Y., Wu W.L., Huang S., Zhang J., Chen H. and Xia N., Serological survey of antibodies to influenza A viruses in a group of people without a history of influenza vaccination, Clinical Microbiology and Infection. 2011, 17: 1347-9.

Lai A.C.K., Wu W.L., Lau S.Y., Guan Y. and Chen H., Two-dimension antigenic dendrogram and phylogenetic tree of avian influenza virus H5N1, FEMS Immunol Med Microbiol. 2011, 64: 205-11.

Tse H., Kao R.Y.T., Wu W.L., Lim W.W., Chen H., Yeung M.Y., Woo P.C.Y., Sze K.H. and Yuen K.Y., Structural basis and sequence co-evolution analysis of the hemagglutinin protein of the pandemic influenza A/H1N1 (2009) virus, Experimental Biology and Medicine. 2011, 236: 915-25.

Wu W.L., Lau S.Y., Chen Y., Wang G., Mok B.W.Y., Wen X., Wang P., Song W., Lin T., Chan K.H., Yuen K.Y. and Chen H., 2008-2009 H1N1 influenza virus exhibits reduced susceptibility to antibody inhibition: implications for the prevalence of oseltamivir resistant variant viruses, Antiviral Research. . 2011, 93: 144-53.

Researcher : Wu Y

List of Research Outputs

Lau S.K.P., Woo P.C.Y., Yeung C., Teng L.L., Wu Y., Bai R., Fan Y.Y., Chan K.H. and Yuen K.Y., Identification and characterization of bocaviruses in cats and dogs revealed a novel feline bocavirus and a novel genetic group of canine bocavirus, Journal of General Virology. 2012, 93: 1573-1582.

Lau S.K.P., Woo P.C.Y., Yip C.Y., Choi K.Y., Wu Y., Bai R., Fan Y.Y., Lai K.Y., Chan K.H. and Yuen K.Y., Identification of a novel feline picornavirus from the domestic cat, Journal of Virology . 2011, 86: 395-405.

Woo P.C.Y., Lau S.K.P., Wong B.H.L., Fan Y.Y., Wong Y.P., Zhang J., Wu Y., Choi K.Y., Li K.S.M., Hui J., Wang M., Zheng B., Chan K.H. and Yuen K.Y., Feline morbillivirus, a previously undescribed paramyxovirus associated with tubulointerstitial nephritis in domestic cats, Proceedings of the National Academy of Sciences of the USA. 2012, 109: 5435-5440.

Woo P.C.Y., Lau S.K.P., Wong B.H.L., Wu Y., Lam S.F. and Yuen K.Y., Novel variant of Beilong paramyxovirus in rats, China, Emerging Infectious Diseases. 2012, 18: 1022-1024.

Researcher : Yam WC

List of Research Outputs

Chen J.H., Wong K.H., Chan K.C., To S.W., Chen Z. and Yam W.C., Phylodynamics of HIV-1 subtype B among the men-having-sex-with-men (MSM) population in Hong Kong, PLoS One.. 2011, 6(9): e25286.

Cheng V.C.C., Yam W.C., Yau M.C.Y., Siu G.K.H., Wong S.C.Y., Chan J.F.W., To K.K.W., Tse H., Hung I.F.N., Tai J.W.M., Ho P.L. and Yuen K.Y., Epidemiology Of Klebsiella Oxytoca-associated Diarrhea Detected By Simmons Citrate Agar Supplemented With Inositol, Tryptophan, And Bile Salts., J Clin Microbiol. 2012, 50(5):1571-9.

Ho P.L., Lo W.U., Lai E.L.Y., Chow K.H. and Yam W.C., Escherichia coli O25b-ST131 is an important cause of antimicrobial-resistant infections in women with uncomplicated cystitis, Journal of Antimicrobial Chemotherapy. 2012.

Ho P.L., Yeung M.K., Lo W.U., Tse H., Li Z., Lai E.L.Y., Chow K.H., To K.K.W. and Yam W.C., Predominance of pHK01-like incompatibility group FII plasmids encoding CTX-M-14 among extended-spectrum beta-lactamase-producing Escherichia coli in Hong Kong, 1996-2008, Diagnostic Microbiology and Infectious Diseases. 2012, 73: 182-186.

Lam T.H., Yuen K.Y., Ho P.L., Weng X.H., Zhang W.H., Chen S. and Yam W.C., Truncated Rv2820c enhances mycobacterial virulence ex vivo and in vivo, Microbial pathogenesis. England, London ; Orlando : Academic Press, 2012, 50 (6): 331-335.

Researcher : Yang Z

List of Research Outputs

Zhang M., Yuan T., Rosa Borges A., Watkins J.D., Guenaga J., Yang Z., Li J., Wang Y., Li Y., Polonis V.R., Pincus S.H., Ruprecht R. and Dimitrov D.S., Identification and Characterization of a Cross-Reactive HIV-1-Neutralizing Human Monoclonal Antibody that Binds to Both gp120 and gp41 , The 8th Annual Protein Engineering Summit, Boston, USA. 2012.

Researcher : Yau MCY

List of Research Outputs

Cheng V.C.C., Yam W.C., Yau M.C.Y., Siu G.K.H., Wong S.C.Y., Chan J.F.W., To K.K.W., Tse H., Hung I.F.N., Tai J.W.M., Ho P.L. and Yuen K.Y., Epidemiology Of Klebsiella Oxytoca-associated Diarrhea Detected By Simmons Citrate Agar Supplemented With Inositol, Tryptophan, And Bile Salts., J Clin Microbiol. 2012, 50(5):1571-9.

Researcher : Yen H

Project Title:	The role of balanced hemagglutinin-neuraminidase activity on the genesis of transmissible NA inhibitor-resistant variants in seasonal and novel pandemic influenza A H1N1 viruses
Investigator(s):	Yen H, Peiris JSM
Department:	Microbiology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2010

Project Title:	Role of influenza hemagglutinin glycoprotein in activation of dendritic cells and induction of effective immune response through C-type lectin receptors
Investigator(s):	Yen H, Peiris JSM, Tu W
Department:	Microbiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2011

Project Title:	Evaluating effect of pandemic H1N1 matrix protein 1 on viral replication in vitro
Investigator(s):	Yen H, Peiris JSM
Department:	School of Public Health
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2012

List of Research Outputs

Mok K.P., Yen H., Yu Y.M., Yuen K.M., Sia S.F., Chan M.C.W., Qin G., Tu W. and Peiris J.S.M., Amino Acid Residues 253 and 591 of the PB2 Protein of Avian Influenza Virus A H9N2 Contribute to Mammalian Pathogenesis, Journal of Virology. 2011, 85(18): 9641-9645.

Yen H., Hemagglutinin-Neuraminidase Balance and the Transmissibility of the Influenza Virus – A Complex Question , IBMS Seminar, Academia Sinica. 2011.

Yen H., Liang C.-.H., Wu C.-.Y., Forrest H., Ferguson A., Choy K.T., Jones J., Wong D.D.Y., Cheung P.H.P., Hsu C.-.H., Li O.T.W., Yuen K.M., Chan W.Y., Poon L.L.M., Chan M.C.W., Nicholls J.M., Krauss S., Wong C.-.H., Guan Y., Webster R.G., Webby R. and Peiris J.S.M., Hemagglutinin-neuraminidase balance confers respiratory-droplet transmissibility of the pandemic H1N1 influenza virus in ferrets, Proceedings of National Academic Science (USA). 2011, 108: 14264-14269.

Yen H., Hemagglutinin–neuraminidase balance confers respiratory-droplet transmissibility of the pandemic H1N1 influenza virus in ferrets, 2011 International Symposium on RNA Viruses (Virus-Host Interactions), November 11th-12th, 2011 in Chang Gung University,Taoyuan, Taiwan R.O.C. 2011.

Researcher : Yeung C

List of Research Outputs

Lau S.K.P., Woo P.C.Y., Yeung C., Teng L.L., Wu Y., Bai R., Fan Y.Y., Chan K.H. and Yuen K.Y., Identification and characterization of bocaviruses in cats and dogs revealed a novel feline bocavirus and a novel genetic group of canine bocavirus, Journal of General Virology. 2012, 93: 1573-1582.

Researcher : Yeung EYH

List of Research Outputs

Teng L.L., Yeung M.Y., Yue G., Au-Yeung R.K.H., Yeung E.Y.H., Fung A.M.Y., Tse H., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., In silico analysis of 16S rRNA gene sequencing based methods for identification of medically important aerobic Gram-negative bacteria, Journal of Medical Microbiology. 2011, 2011, 60: 1281-1286.

Researcher : Yeung MK

List of Research Outputs

Ho P.L. and Yeung M.K., Epidemiology of CTX-M type extended-spectrum beta-lactamase-producing Escherichia coli among blood culture isolates in Hong Kong, Pokfulam Road, Hong Kong, University of Hong Kong, 2011.

Ho P.L., Yeung M.K., Lo W.U., Tse H., Li Z., Lai E.L.Y., Chow K.H., To K.K.W. and Yam W.C., Predominance of pHK01-like incompatibility group FII plasmids encoding CTX-M-14 among extended-spectrum beta-lactamase-producing Escherichia coli in Hong Kong, 1996-2008, Diagnostic Microbiology and Infectious Diseases. 2012, 73: 182-186.

Researcher : Yeung ML

Project Title:	Identification of Hepatitis B virus (HBV) receptors
Investigator(s):	Yeung ML, Yuen KY
Department:	Microbiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2011
Completion Date:	11/2012

Project Title:	Biosicence for the 21st Century: Emerging Frontiers and Evolving Concepts A genome-wide short hairpin (shRNA) screening of host factors essential for Enterovirus 71 (EV71) replication
Investigator(s):	Yeung ML
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2011
Completion Date:	07/2011

List of Research Outputs

Woo P.C.Y., Lau S.K.P., Choi K.Y., Huang Y., Teng L.L., Tsoi H.W., Tse H., Yeung M.L., Chan K.H., Jin D. and Yuen K.Y., Natural occurrence and characterization of two IRES elements in a novel virus, canine picodicistrovirus, in the picornavirus-like superfamily, Journal of Virology. 2011, 86: 2797-2808.

Researcher : Yeung MY

List of Research Outputs

Teng L.L., Yeung M.Y., Yue G., Au-Yeung R.K.H., Yeung E.Y.H., Fung A.M.Y., Tse H., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., In silico analysis of 16S rRNA gene sequencing based methods for identification of medically important aerobic Gram-negative bacteria, Journal of Medical Microbiology. 2011, 2011, 60: 1281-1286.

Tse H., Kao R.Y.T., Wu W.L., Lim W.W., Chen H., Yeung M.Y., Woo P.C.Y., Sze K.H. and Yuen K.Y., Structural basis and sequence co-evolution analysis of the hemagglutinin protein of the pandemic influenza A/H1N1 (2009) virus, Experimental Biology and Medicine. 2011, 236: 915-25.

Researcher : Yip CH

List of Research Outputs

Zhu H., Li L., Zeng Y., Zhou J., Zheng Z., Chen R., Zheng R., Duan L., Yip C.H., Huang K., Lam T.Y., Wang J., Chen H., Webster R.G., Webby R., Peiris J.S.M., Smith D.K. and Guan Y., Pandemic H1N1/2009 virus in swine: prevalence and genesis of reassortants with the potential to infect humans., 4th International Influenza Conference: Influenza2011 Zoonotic Influenza and Human Health. 2011.

Researcher : Yip CY

Project Title:	Complete genome sequence analysis of human enterovirus 71 strains from 2004 to 2010 in Hong Kong
Investigator(s):	Yip CY, Lau SKP, Woo PCY
Department:	Microbiology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Mini Grants
Start Date:	11/2011

List of Research Outputs

Lau S.K.P., Woo P.C.Y., Lai K.Y., Huang Y., Yip C.Y., Shek C.T., Lee P., Lam S.F., Chan K.H. and Yuen K.Y., Complete genome analysis of three novel picornaviruses from diverse bat species, Journal of Virology. 2011, 85: 8819-8828.

Lau S.K.P., Woo P.C.Y., Yip C.Y., Choi K.Y., Wu Y., Bai R., Fan Y.Y., Lai K.Y., Chan K.H. and Yuen K.Y., Identification of a novel feline picornavirus from the domestic cat, Journal of Virology . 2011, 86: 395-405.

Lau S.K.P., Woo P.C.Y., Yip C.Y., Fan Y.Y., Huang Y., Wang M., Guo R., Lam S.F., Tsang K.L., Lai K.Y., Chan K.H., Che X.Y., Zheng B. and Yuen K.Y., Isolation and characterization of a novel Betacoronavirus subgroup A coronavirus, rabbit coronavirus HKU14, from domestic rabbits, Journal of Virology. 2012, 86: 5481-5496.

Lau S.K.P., Lee P., Tsang K.L., Yip C.Y., Tse H., Lee R.A., So L.Y., Lau Y.L., Chan K.H., Woo P.C.Y. and Yuen K.Y., Molecular epidemiology of human coronavirus OC43 reveals evolution of different genotypes over time and recent emergence of a novel genotype due to natural recombination., Journal of Virology. 2011, 85: 11325-11337.

Yip C.Y., Lau S.K.P., Woo P.C.Y., Chan K.H. and Yuen K.Y., Complete genome sequence of a coxsackievirus A22 strain in Hong Kong reveals a natural intratypic recombination event, Journal of Virology . 2011, 85: 12098-12099.

Researcher : Yu CL

List of Research Outputs

Yu C.L., Chan W.Y., Wang J., Travanty E.A., Nicholls J.M., Peiris J.S.M., Mason R.J. and Chan M.C.W., Viral Replication and Innate Host Responses in Primary Human Alveolar Epithelial Cells and Alveolar Macrophages Infected with Influenza H5N1 and H1N1 Viruses. , Journal of Virology. 2011, 85 (14): 6844-6855.

Researcher : Yu YM

List of Research Outputs

Mok K.P., Yen H., Yu Y.M., Yuen K.M., Sia S.F., Chan M.C.W., Qin G., Tu W. and Peiris J.S.M., Amino Acid Residues 253 and 591 of the PB2 Protein of Avian Influenza Virus A H9N2 Contribute to Mammalian Pathogenesis, Journal of Virology. 2011, 85(18): 9641-9645.

Researcher : Yuan T

List of Research Outputs

Yuan T., Li J. and Zhang M., A single mutation turns a non-binding germline-like predecessor of broadly neutralizing antibody into a binding antibody to HIV-1 envelope glycoproteins, MAbs. 2011, 3(4).

Zhang M., Yuan T., Rosa Borges A., Watkins J.D., Guenaga J., Yang Z., Li J., Wang Y., Li Y., Polonis V.R., Pincus S.H., Ruprecht R. and Dimitrov D.S., Identification and Characterization of a Cross-Reactive HIV-1-Neutralizing Human Monoclonal Antibody that Binds to Both gp120 and gp41 , The 8th Annual Protein Engineering Summit, Boston, USA. 2012.

Researcher : Yuen K.Y.

Project Title:	Establishment of core facilities for the HKU HIV/AIDS research laboratories
Investigator(s):	Yuen KY, Zheng B, Woo PCY, Yam WC, Im SWK
Department:	Microbiology
Source(s) of Funding:	Council for the AIDS Trust Fund - General Award
Start Date:	11/2001

Project Title:	Bacteraemia caused by Anaerotruncus colihominis and emended description of the species
Investigator(s):	Yuen KY, Lau SKP, Woo PCY
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	09/2005

Project Title:	Discovery and characterization of novel microbes with epidemic potential
Investigator(s):	Yuen KY
Department:	Microbiology
Source(s) of Funding:	Croucher Senior Medical Research Fellowships
Start Date:	01/2007

Project Title:	Investigation of invasive Lasiodiplodia theobromae infections in humans
Investigator(s):	Yuen KY, Tse H, Woo PCY, Lau SKP
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	09/2007

Project Title:	Internal Award for CAE Membership
Investigator(s):	Yuen KY
Department:	Microbiology
Source(s) of Funding:	Internal Award for Chinese Academy of Engineering Membership
Start Date:	02/2008

Project Title:	Molecular epidemiological investigation of PARV-4-related viruses in HK and southern China
Investigator(s):	Yuen KY, Tse H, Lau SKP, Woo PCY
Department:	Microbiology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	10/2008

Project Title:	Infection and Immunology
Investigator(s):	Yuen KY
Department:	Microbiology
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	11/2008

List of Research Outputs

Researcher : Yuen KM

List of Research Outputs

Mok K.P., Yen H., Yu Y.M., Yuen K.M., Sia S.F., Chan M.C.W., Qin G., Tu W. and Peiris J.S.M., Amino Acid Residues 253 and 591 of the PB2 Protein of Avian Influenza Virus A H9N2 Contribute to Mammalian Pathogenesis, Journal of Virology. 2011, 85(18): 9641-9645.

Researcher : Yuen KY

Project Title:	Establishment of core facilities for the HKU HIV/AIDS research laboratories
Investigator(s):	Yuen KY, Zheng B, Woo PCY, Yam WC, Im SWK
Department:	Microbiology
Source(s) of Funding:	Council for the AIDS Trust Fund - General Award
Start Date:	11/2001

Project Title:	Bacteraemia caused by Anaerotruncus colihominis and emended description of the species
Investigator(s):	Yuen KY, Lau SKP, Woo PCY
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	09/2005

Project Title:	Discovery and characterization of novel microbes with epidemic potential
Investigator(s):	Yuen KY
Department:	Microbiology
Source(s) of Funding:	Croucher Senior Medical Research Fellowships
Start Date:	01/2007

Project Title:	Investigation of invasive Lasiodiplodia theobromae infections in humans
Investigator(s):	Yuen KY, Tse H, Woo PCY, Lau SKP
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	09/2007

Project Title:	Internal Award for CAE Membership
Investigator(s):	Yuen KY
Department:	Microbiology
Source(s) of Funding:	Internal Award for Chinese Academy of Engineering Membership
Start Date:	02/2008

Project Title:	Molecular epidemiological investigation of PARV-4-related viruses in HK and southern China
Investigator(s):	Yuen KY, Tse H, Lau SKP, Woo PCY
Department:	Microbiology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	10/2008

Project Title:	Infection and Immunology
Investigator(s):	Yuen KY
Department:	Microbiology
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	11/2008

List of Research Outputs

Chan J.F.W., Lau S.K.P., Curreem S.O.T., To K.K.W., Leung S.S.M., Cheng V.C.C., Yuen K.Y. and Woo P.C.Y., First report of spontaneous intrapartum Atopobium vaginae bacteremia, Journal of Clinical Microbiology. 2012, 50: 2525-2528.

Chan J.F.W., Woo P.C.Y., Teng L.L., Lau S.K.P., Leung S.S.M., Tam F.C.C. and Yuen K.Y., Primary infective spondylodiscitis caused by Lactococcus garvieae and a review of human L. garvieae infections, Infection. 2011, 39: 259-264.

Cheng V.C.C., Yam W.C., Yau M.C.Y., Siu G.K.H., Wong S.C.Y., Chan J.F.W., To K.K.W., Tse H., Hung I.F.N., Tai J.W.M., Ho P.L. and Yuen K.Y., Epidemiology Of Klebsiella Oxytoca-associated Diarrhea Detected By Simmons Citrate Agar Supplemented With Inositol, Tryptophan, And Bile Salts., J Clin Microbiol. 2012, 50(5):1571-9.

Cheng V.C.C., Yam W.C., Tsang L.L., Yau M.C.Y., Siu G.K.H., Wong S.C.Y., Chan J.F.W., To K.K.W., Tse H., Hung I.F.N., Tai J.W.M., Ho P.L. and Yuen K.Y., Epidemiology of Klebsiella oxytoca-associated diarrhea detected by Simmons citrate agar supplemented with inositol, tryptophan, and bile salts, Journal of Clinical Microbiology. 2012, 50: 1571-9.

Ho C.C., Wu A.K.L., Tse C.W.S., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Automated pangenomic analysis in target selection for PCR detection and identification of bacteria by use of ssGeneFinder Webserver and its application to Salmonella enterica serovar Typhi, Journal of Clinical Microbiology. 2012, 50: 1905-1911.

Ho C.C., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Rapid identification and validation of specific molecular targets for detection of Escherichia coli O104:H4 outbreak strain using high-throughput sequencing data from nine genomes, Journal of Clinical Microbiology. 2011, 49: 3714-3716.

Kao R.Y.T. and Yuen K.Y., Faculty Outstanding Research Award, LKS Faculty of Medicine, HKU. 2011.

Lam T.H., Yuen K.Y., Ho P.L., Weng X.H., Zhang W.H., Chen S. and Yam W.C., Truncated Rv2820c enhances mycobacterial virulence ex vivo and in vivo, Microbial pathogenesis. England, London ; Orlando : Academic Press, 2012, 50 (6): 331-335.

Lau G.K.K., Chan J.F.W., Yuen K.Y., Tse C.T.A., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Hon F.K.S., Kwan M.W.M., Mak W., Cheung R.T.F. and Ho S.L., Clinical And Neuroradiological Features Of Viral Encephalitis: A Hospital-based Study, 17th Medical Research Conference, Hong Kong Medical Journal. 2012, 18 (Suppl 1): 31.

Lau G.K.K., Chan J.F., Yuen K.Y., Tse C.T.A., Chang S.K.R., Pang S.Y.Y., Lee J.C.Y., Kwan W.M.M., Hon F.K.S., Mak W., Cheung R.T.F., Ho S.L. and Chan K.H., Clinical and neuroradiological features of viral encephalitis: a hospital based study, 17th Medical Research Conference, Department of Medicine, The University of Hong Kong, Hong Kong Medical Journal. 2012, 18 (Suppl 1): 31.

Lau S.K.P., Woo P.C.Y., Lai K.Y., Huang Y., Yip C.Y., Shek C.T., Lee P., Lam S.F., Chan K.H. and Yuen K.Y., Complete genome analysis of three novel picornaviruses from diverse bat species, Journal of Virology. 2011, 85: 8819-8828.

Lau S.K.P., Curreem S.O.T., Ngan H.Y., Yeung C.K., Yuen K.Y. and Woo P.C.Y., First report of disseminated Mycobacterium skin infections in two liver transplant recipients and rapid diagnosis by hsp65 gene sequencing, Journal of Clinical Microbiology. 2011, 49: 3733-3737.

Lau S.K.P., Fan Y.Y., Lo H.W., Ng R.H.Y., Wong S.S.Y., Li W.S., Wu A.K.L., Ng K.H.L., Tseung S., Lee R.A., Fung K.S.C., Que T.L., Yuen K.Y. and Woo P.C.Y., High mortality associated with Catabacter hongkongensis bacteremia, Journal of Clinical Microbiology. 2012, 50: 2239-2243.

Lau S.K.P., Woo P.C.Y., Yeung C., Teng L.L., Wu Y., Bai R., Fan Y.Y., Chan K.H. and Yuen K.Y., Identification and characterization of bocaviruses in cats and dogs revealed a novel feline bocavirus and a novel genetic group of canine bocavirus, Journal of General Virology. 2012, 93: 1573-1582.

Lau S.K.P., Woo P.C.Y., Yip C.Y., Choi K.Y., Wu Y., Bai R., Fan Y.Y., Lai K.Y., Chan K.H. and Yuen K.Y., Identification of a novel feline picornavirus from the domestic cat, Journal of Virology . 2011, 86: 395-405.

Lau S.K.P., Woo P.C.Y., Yip C.Y., Fan Y.Y., Huang Y., Wang M., Guo R., Lam S.F., Tsang K.L., Lai K.Y., Chan K.H., Che X.Y., Zheng B. and Yuen K.Y., Isolation and characterization of a novel Betacoronavirus subgroup A coronavirus, rabbit coronavirus HKU14, from domestic rabbits, Journal of Virology. 2012, 86: 5481-5496.

Lau S.K.P., Tang B.S.F., Curreem S.O.T., Chan T.M., Martelli P., Tse C.W.S., Wu A.K.L., Yuen K.Y. and Woo P.C.Y., Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry for Rapid Identification of Burkholderia pseudomallei: Importance of Expanding Databases with Pathogens Endemic to Different Localities., Journal of Clinical Microbiology. 2012, 50: 3142-3.

Lau S.K.P., Lee P., Tsang K.L., Yip C.Y., Tse H., Lee R.A., So L.Y., Lau Y.L., Chan K.H., Woo P.C.Y. and Yuen K.Y., Molecular epidemiology of human coronavirus OC43 reveals evolution of different genotypes over time and recent emergence of a novel genotype due to natural recombination., Journal of Virology. 2011, 85: 11325-11337.

Lau S.K.P., Fan Y.Y., Wong G.K.M., Teng L.L., Sze K.H., Tse H., Yuen K.Y. and Woo P.C.Y., Transport genes and chemotaxis in Laribacter hongkongensis: a genome-wide analysis, Cell and Bioscience. 2011, 1: 28.

Lei T., Siu K.L., Koh K.H., Chan K.H., Hung I.F.N., To K.K.W. and Yuen K.Y., Anti-ganglioside Antibodies Were Not Detected In Human Subjects Infected With Or Vaccinated Against 2009 Pandemic Influenza A (h1n1) Virus., Vaccine. 2012, 30(16):2605-10.

Lei T., Siu K.L., Kok K.H., Chan K.H., Chan E.Y.T., Hung I.F.N., To K.K.W., Li P.C.K., Zhou J., Zheng B., Yuen K.Y., Wang M. and Jin D., Anti-ganglioside antibodies were not detected in human subjects infected with or vaccinated against 2009 pandemic influenza A (H1N1) virus., Vaccine. 2012, 30: 2605-2610.

Singh G.H., Ip A.H., So J.C.C., Cheng V.C.C., Wong C.S., Yuen K.Y. and Kwong Y.L., Disseminated cryptococcosis mimicking a lymphoma, Eur J Haematol. 2012, 88(3): 275-6.

Teng L.L., Yeung M.Y., Yue G., Au-Yeung R.K.H., Yeung E.Y.H., Fung A.M.Y., Tse H., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., In silico analysis of 16S rRNA gene sequencing based methods for identification of medically important aerobic Gram-negative bacteria, Journal of Medical Microbiology. 2011, 2011, 60: 1281-1286.

Tse H., Lau S.K.P., Chan W.M., Choi K.Y., Woo P.C.Y. and Yuen K.Y., Complete genome sequences of novel canine noroviruses in Hong Kong, Journal of Virology. 2012, 86: 9531-9532.

Tse H., Chan W.M., Li K.S.M., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Discovery and genomic characterization of a novel bat sapovirus with unusual genomic features and phylogenetic position, PLoS One. 2012, 7: e34987.

Tse H., Tsoi H.W., Teng L.L., Chen X.C., Liu H., Zhou B., Zheng B., Woo P.C.Y., Lau S.K.P. and Yuen K.Y., Discovery and genomic characterization of a novel ovine partetravirus and a new genotype of bovine partetravirus, PLoS One. 2011, 6: e25619.

Tse H., Chan W.M., Tsoi H.W., Fan Y.Y., Lau C.Y., Lau S.K.P., Woo P.C.Y. and Yuen K.Y., Rediscovery and genomic characterization of bovine astroviruses, Journal of General Virology. 2011, 2011, 92: 1888-1898.

Tse H., Kao R.Y.T., Wu W.L., Lim W.W., Chen H., Yeung M.Y., Woo P.C.Y., Sze K.H. and Yuen K.Y., Structural basis and sequence co-evolution analysis of the hemagglutinin protein of the pandemic influenza A/H1N1 (2009) virus, Experimental Biology and Medicine. 2011, 236: 915-25.

Wang Y.F., Cai J.P., Wang Y.D., Dong H., Hao W., Jiang L.X., Long J., Chan C.M., Woo P.C.Y., Lau S.K.P., Yuen K.Y. and Che X.Y., Immunoassays based on Penicillium marneffei Mp1p derived from Pichia pastoris expression system for diagnosis of penicilliosis, PLoS One. 2011, 6: e28796.

Wong M.Y., Lau S.K.P., Tang S.C.W., Curreem S.O.T., Woo P.C.Y. and Yuen K.Y., First Report of Peritoneal Dialysis-Related Peritonitis Caused by Citrobacter amalonaticus, Peritoneal Dialysis International. 2012, 32: 224-225.

Woo P.C.Y., Leung S.Y., Ngan A.H.Y., Lau S.K.P. and Yuen K.Y., A significant number of reported Absidia corymbifera (Lichtheimia corymbifera) infections are caused by Lictheimia ramosa (syn. Lichtheimia hongkongensis): an emerging cause of mucormycosis, Emerging Microbes & Infections. 2012, 1: e12.

Woo P.C.Y., Lau S.K.P., Wong B.H.L., Wong Y.P., Poon W.S.R. and Yuen K.Y., Complete genome sequence of a novel paramyxovirus, Tailam virus, discovered in Sikkim rats, Journal of Virology. 2011, 85: 13473-13474.

Woo P.C.Y., Lau S.K.P., Bai R., Teng L.L., Lee P., Martelli P., Hui S.W. and Yuen K.Y., Complete genome sequence of a novel picobirnavirus, otarine picobirnavirus, discovered in California sea lions, Journal of Virology. 2012, 86: 6377-6378.

Woo P.C.Y., Lau S.K.P., Lam S.F., Lau C.Y., Tsang K.L., Lau J.H.N., Bai R., Teng L.L., Tsang C.C.C., Wang M., Zheng B., Chan K.H. and Yuen K.Y., Discovery of seven novel mammalian and avian coronaviruses in Deltacoronavirus supports bat coronaviruses as the gene source of Alphacoronavirus and Betacoronavirus and avian coronaviruses as the gene source of Gammacoronavirus and Deltacoronavirus, Journal of Virology. 2012, 86: 3995-4008.

Woo P.C.Y., Lau S.K.P., Liu B., Cai J.J., Chong T.K., Tse H., Kao R.Y.T., Chan C.M., Chow W.N. and Yuen K.Y., Draft genome sequence of Penicillium marneffei strain PM1, Eukaryotic Cell. 2011, 10: 1740-1741.

Woo P.C.Y., Lau S.K.P., Wong B.H.L., Fan Y.Y., Wong Y.P., Zhang J., Wu Y., Choi K.Y., Li K.S.M., Hui J., Wang M., Zheng B., Chan K.H. and Yuen K.Y., Feline morbillivirus, a previously undescribed paramyxovirus associated with tubulointerstitial nephritis in domestic cats, Proceedings of the National Academy of Sciences of the USA. 2012, 109: 5435-5440.

Woo P.C.Y., Lau S.K.P., Choi K.Y., Huang Y., Teng L.L., Tsoi H.W., Tse H., Yeung M.L., Chan K.H., Jin D. and Yuen K.Y., Natural occurrence and characterization of two IRES elements in a novel virus, canine picodicistrovirus, in the picornavirus-like superfamily, Journal of Virology. 2011, 86: 2797-2808.

Woo P.C.Y., Lau S.K.P., Wong B.H.L., Wu Y., Lam S.F. and Yuen K.Y., Novel variant of Beilong paramyxovirus in rats, China, Emerging Infectious Diseases. 2012, 18: 1022-1024.

Wu W.L., Lau S.Y., Chen Y., Wang G., Mok B.W.Y., Wen X., Wang P., Song W., Lin T., Chan K.H., Yuen K.Y. and Chen H., 2008-2009 H1N1 influenza virus exhibits reduced susceptibility to antibody inhibition: implications for the prevalence of oseltamivir resistant variant viruses, Antiviral Research. . 2011, 93: 144-53.

Yang W., Chen W., Wang H., Ho J.W.S., Huang J., Woo P.C.Y., Lau S.K.P., Yuen K.Y., Zhang Q., Zhou W., Bartlam M., Watt R.M. and Rao Z., Structural and functional insight into the mechanism of an alkaline exonuclease from Laribacter hongkongensis, Nucleic Acids Research. 2011, 39(22): 9803-19.

Yip C.Y., Lau S.K.P., Woo P.C.Y., Chan K.H. and Yuen K.Y., Complete genome sequence of a coxsackievirus A22 strain in Hong Kong reveals a natural intratypic recombination event, Journal of Virology . 2011, 85: 12098-12099.

Yu B., Yang M., Shi L., Yao Y.D., Jiang Q.Q., Li X.F., Tang L.H., Zheng B., Yuen K.Y., Smith D.K., Song E.W. and Huang J., Explicit hypoxia targeting with tumor suppression by creating an "obligate" anaerobic Salmonella Typhimurium strain , Scientific Reports . 2012, 2: 436.

Zhang J., To K.K.W., Tse H., Chan K.H., Hung I.F.N. and Yuen K.Y., High Incidence Of Severe Influenza Among Individuals Over 50 Years Of Age., Clin Vaccine Immunol . 2011, 18(11):1918-24.

Researcher : Zhang H

Project Title:	A pilot study for the role of TH17 in chronic hepatitis B patients
Investigator(s):	Zhang H, Zheng B
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	10/2010

Project Title:	the 1st european conference of microbiology and immunology Low Th17 expression association with Chronic Hepatitis B viral infection by means of reducing viral specific IFNγ releasing in a HBV infection model of IL-17 KO mice
Investigator(s):	Zhang H
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2011

Researcher : Zhang J

Project Title:	Mechanisms study of 2009 pandemic H1N1 influenza causes severe infection in obese Mice
Investigator(s):	Zhang J, Yuen KY
Department:	Microbiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	09/2011
Completion Date:	09/2012

List of Research Outputs

Woo P.C.Y., Lau S.K.P., Wong B.H.L., Fan Y.Y., Wong Y.P., Zhang J., Wu Y., Choi K.Y., Li K.S.M., Hui J., Wang M., Zheng B., Chan K.H. and Yuen K.Y., Feline morbillivirus, a previously undescribed paramyxovirus associated with tubulointerstitial nephritis in domestic cats, Proceedings of the National Academy of Sciences of the USA. 2012, 109: 5435-5440.

Zhang J., To K.K.W., Tse H., Chan K.H., Hung I.F.N. and Yuen K.Y., High Incidence Of Severe Influenza Among Individuals Over 50 Years Of Age., Clin Vaccine Immunol . 2011, 18(11):1918-24.

Researcher : Zhang JX

Project Title:	Mechanisms study of 2009 pandemic H1N1 influenza causes severe infection in obese Mice
Investigator(s):	Zhang J, Yuen KY
Department:	Microbiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	09/2011
Completion Date:	09/2012

List of Research Outputs

Researcher : Zhang K

List of Research Outputs

Zhang K., Yu B., Cao T., Zhang N. and Huang J., A preliminary study for development of oral vaccines for poultry and wild birds against avian H5N1 influenza virus, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Researcher : Zhang M

Project Title:	Identification of HIV-1 vaccine immunogens by antibody in vitro maturation
Investigator(s):	Zhang M
Department:	Medical Faculty
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	12/2009
Completion Date:	06/2012

Project Title:	Identification of HIV-1-specific broadly neutralizing human monoclonal antibodies from the B-cell genomic DNA antibody gene repertoires of HIV-1 infected individuals
Investigator(s):	Zhang M
Department:	Medical Faculty
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2010

Project Title:	Development of yeast display technology for antibody engineering
Investigator(s):	Zhang M
Department:	Microbiology
Source(s) of Funding:	Small Project Funding
Start Date:	03/2011
Completion Date:	02/2012

Project Title:	Reconstitution and Characterization of HIV-specific Antibody Repertoires in vitro: Implications for Passive Immunization
Investigator(s):	Zhang M
Department:	Microbiology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	08/2011

Project Title:	Development of a "Two-in-One" Duel Specific Antibody Therapeutics for Treatment of Breast Cancer
Investigator(s):	Zhang M
Department:	Microbiology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	11/2011

Project Title:	Development of a "Two-in-One" Duel Specific Antibody Therapeutics for Treatment of Breast Cancer
Investigator(s):	Zhang M, Srivastava V, Li J
Department:	Microbiology
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	11/2011

Project Title:	Eighth Annual Protein Engineering Summit (PEGS) Identification and Characterization of a Cross-Reactive HIV-1-Neutralizing Human Monoclonal Antibody that Binds to Both gp120 and gp41
Investigator(s):	Zhang M
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2012

Project Title:	Development of intrabodies targeting eukaryotic translation initiation factor 5A2 for cancer treatment
Investigator(s):	Zhang M, Guan X
Department:	Microbiology
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	06/2012

List of Research Outputs

Fu X.-.Y., Chen C., Pan H.-.X., Huang T.A.O., Zhang M. and Zheng H.O.N.G., Inhibition of breast cancer cell proliferation and migration by monoclonal antibody m590 specific for insulin-like growth factor receptor type I , Chinese Journal of Experimental Surgery. 中华实验外科杂志, 2012, 29: 824-926.

Yuan T., Li J. and Zhang M., A single mutation turns a non-binding germline-like predecessor of broadly neutralizing antibody into a binding antibody to HIV-1 envelope glycoproteins, MAbs. 2011, 3(4).

Zhang M., Broadly Cross-Reactive HIV-1-Specific Antibodies For Prevention And Treatment of HIV, Patent Application No. 13/534,834.. 2012.

Zhang M., Editorial Board Member, ISRN Preventive Medicine. 2012.

Zhang M., Yuan T., Rosa Borges A., Watkins J.D., Guenaga J., Yang Z., Li J., Wang Y., Li Y., Polonis V.R., Pincus S.H., Ruprecht R. and Dimitrov D.S., Identification and Characterization of a Cross-Reactive HIV-1-Neutralizing Human Monoclonal Antibody that Binds to Both gp120 and gp41 , The 8th Annual Protein Engineering Summit, Boston, USA. 2012.

Researcher : Zhang N

List of Research Outputs

Zhang K., Yu B., Cao T., Zhang N. and Huang J., A preliminary study for development of oral vaccines for poultry and wild birds against avian H5N1 influenza virus, 16th Research Postgraduate Symposium, HKU, December 7-8, 2011. Hong Kong.

Researcher : Zheng B

Project Title:	CCR5 expression on antigen-presenting cens in HIV infection
Investigator(s):	Zheng B, Lee SS
Department:	Microbiology
Source(s) of Funding:	Council for the AIDS Trust Fund - General Award
Start Date:	01/2001

Project Title:	The pattern of chemokine receptor polymorphism in healthy and HIV positive Chinese adults
Investigator(s):	Zheng B, Lee SS
Department:	Microbiology
Source(s) of Funding:	Council for the AIDS Trust Fund - General Award
Start Date:	01/2001

Project Title:	A longitudinal study of HIV-1 drug-resistance for improving management of patients on HARRT (MSS 140R)
Investigator(s):	Zheng B, Lu L, Chan KW
Department:	Microbiology
Source(s) of Funding:	Council for the AIDS Trust Fund - General Award
Start Date:	07/2006

Project Title:	Study of vaccine HA-M2 against H5N1 avian influenza virus
Investigator(s):	Zheng B
Department:	Microbiology
Source(s) of Funding:	Matching Fund for Hi-Tech Research and Development Program of China (863 Projects)
Start Date:	08/2007

Project Title:	Study of AAV- and peptide-based vaccine candidates against influenza virus H5N1 infection in animal model
Investigator(s):	Zheng B, Yuen KY
Department:	Microbiology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	11/2007

Project Title:	Cross-protective efficacy of immunization with different forms of M2 vaccines and their combinations with HA vaccines against highly pathogenic H5N1 influenza A viruses in mice
Investigator(s):	Zheng B, Yuen KY
Department:	Microbiology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	10/2009

Project Title:	Co-administration of antiviral and anti-inflammatory agents against avian influenza virus H5N1 infection in animal model
Investigator(s):	Zheng B, Yuen KY, Jin D
Department:	Microbiology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2010

Project Title:	A feasibility study on anti-H5N1 influenza viral infection using aptamers targeting viral nucleoprotein
Investigator(s):	Zheng B, Zhou J
Department:	Microbiology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	11/2011

Project Title:	Keystone Symposia: Frontiers in HIV Pathogenesis, Therapy and Eradication (X8) In vitro selection of HIV-1 CRF08_BC resistant variants to reverse transcriptase inhibitors
Investigator(s):	Zheng B
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2012
Completion Date:	03/2012

Project Title:	Development of Antiviral Agents based on Small RNA Containing Unique Motif (UIM/215)
Investigator(s):	Zheng B, Zhou J
Department:	Microbiology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	05/2012

Project Title:	Development of Antiviral Agents based on Small RNA Containing Unique Motif (UIM/215)
Investigator(s):	Zheng B, Zhou J
Department:	Microbiology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	05/2012

Project Title:	Development of Antiviral Agents based on Small RNA Containing Unique Motif
Investigator(s):	Zheng B, Zhou J
Department:	Microbiology
Source(s) of Funding:	Matching Grant for Joint Research
Start Date:	05/2012

List of Research Outputs

Chan H.M., Chen L., Liu M., Hu L., Zheng B., Poon K.M., Huang P., Yuan Y.F., Huang J., Yang J., Tsao G.S.W. and Guan X., Translationally controlled tumor protein induces mitotic defects and chromosome missegregation in hepatocellular carcinoma development. , Hepatology . 2012, 55: 491-505.

Kang Y., Wu Z., Lau T., Lu X., Liu L., Cheung K.L.A., Tan Z., Ng J., Liang J., Wang H., Li S., Zheng B., Li B., Chen L. and Chen Z., CCR5 Antagonist TD-0680 Uses a Novel Mechanism for Enhanced Potency against HIV-1 Entry, Cell-mediated Infection, and a Resistant Variant, JBC. JBC, 2012, 287: 16499.

Lau S.K.P., Woo P.C.Y., Yip C.Y., Fan Y.Y., Huang Y., Wang M., Guo R., Lam S.F., Tsang K.L., Lai K.Y., Chan K.H., Che X.Y., Zheng B. and Yuen K.Y., Isolation and characterization of a novel Betacoronavirus subgroup A coronavirus, rabbit coronavirus HKU14, from domestic rabbits, Journal of Virology. 2012, 86: 5481-5496.

Lei T., Siu K.L., Kok K.H., Chan K.H., Chan E.Y.T., Hung I.F.N., To K.K.W., Li P.C.K., Zhou J., Zheng B., Yuen K.Y., Wang M. and Jin D., Anti-ganglioside antibodies were not detected in human subjects infected with or vaccinated against 2009 pandemic influenza A (H1N1) virus., Vaccine. 2012, 30: 2605-2610.

Li T., Fu C., Di B., Wu J., Yang Z., Wang Y., Li M., Lu J., Chen Y., LU E., Geng J., Hu W., Dong Z., Li M.F., Zheng B., Cao K.Y. and Wang M., A Two-Year Surveillance of 2009 Pandemic Influenza A (H1N1) in Guangzhou, China: From Pandemic to Seasonal Influenza?, PLoS One . 2011, 6(11): e28027.

Tse H., Tsoi H.W., Teng L.L., Chen X.C., Liu H., Zhou B., Zheng B., Woo P.C.Y., Lau S.K.P. and Yuen K.Y., Discovery and genomic characterization of a novel ovine partetravirus and a new genotype of bovine partetravirus, PLoS One. 2011, 6: e25619.

Woo P.C.Y., Lau S.K.P., Lam S.F., Lau C.Y., Tsang K.L., Lau J.H.N., Bai R., Teng L.L., Tsang C.C.C., Wang M., Zheng B., Chan K.H. and Yuen K.Y., Discovery of seven novel mammalian and avian coronaviruses in Deltacoronavirus supports bat coronaviruses as the gene source of Alphacoronavirus and Betacoronavirus and avian coronaviruses as the gene source of Gammacoronavirus and Deltacoronavirus, Journal of Virology. 2012, 86: 3995-4008.

Woo P.C.Y., Lau S.K.P., Wong B.H.L., Fan Y.Y., Wong Y.P., Zhang J., Wu Y., Choi K.Y., Li K.S.M., Hui J., Wang M., Zheng B., Chan K.H. and Yuen K.Y., Feline morbillivirus, a previously undescribed paramyxovirus associated with tubulointerstitial nephritis in domestic cats, Proceedings of the National Academy of Sciences of the USA. 2012, 109: 5435-5440.

Yu B., Yang M., Shi L., Yao Y.D., Jiang Q.Q., Li X.F., Tang L.H., Zheng B., Yuen K.Y., Smith D.K., Song E.W. and Huang J., Explicit hypoxia targeting with tumor suppression by creating an "obligate" anaerobic Salmonella Typhimurium strain , Scientific Reports . 2012, 2: 436.

Zhang Q., Zhang X., Wu H., Seto D., Zhang H., Chen Z., Wan C.S. and Zheng B., Parental LTRs Are Important in a Construct of a Stable and Efficient Replication-Competent Infectious Molecular Clone of HIV-1 CRF08_BC, PLoS ONE. 2012, 7(2): e31233.

Zhou J., Tan T., Tian Y., Zheng B., Ou J.H., Huang E.J. and Yen T.S., Krüppel-like factor 15 activates hepatitis B virus gene expression and replication, Hepatology. Hepatology, 2011, 54: 109-21.

Researcher : Zheng B.

Project Title:	CCR5 expression on antigen-presenting cens in HIV infection
Investigator(s):	Zheng B, Lee SS
Department:	Microbiology
Source(s) of Funding:	Council for the AIDS Trust Fund - General Award
Start Date:	01/2001

Project Title:	The pattern of chemokine receptor polymorphism in healthy and HIV positive Chinese adults
Investigator(s):	Zheng B, Lee SS
Department:	Microbiology
Source(s) of Funding:	Council for the AIDS Trust Fund - General Award
Start Date:	01/2001

Project Title:	A longitudinal study of HIV-1 drug-resistance for improving management of patients on HARRT (MSS 140R)
Investigator(s):	Zheng B, Lu L, Chan KW
Department:	Microbiology
Source(s) of Funding:	Council for the AIDS Trust Fund - General Award
Start Date:	07/2006

Project Title:	Study of vaccine HA-M2 against H5N1 avian influenza virus
Investigator(s):	Zheng B
Department:	Microbiology
Source(s) of Funding:	Matching Fund for Hi-Tech Research and Development Program of China (863 Projects)
Start Date:	08/2007

Project Title:	Study of AAV- and peptide-based vaccine candidates against influenza virus H5N1 infection in animal model
Investigator(s):	Zheng B, Yuen KY
Department:	Microbiology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	11/2007

Project Title:	Cross-protective efficacy of immunization with different forms of M2 vaccines and their combinations with HA vaccines against highly pathogenic H5N1 influenza A viruses in mice
Investigator(s):	Zheng B, Yuen KY
Department:	Microbiology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	10/2009

Project Title:	Co-administration of antiviral and anti-inflammatory agents against avian influenza virus H5N1 infection in animal model
Investigator(s):	Zheng B, Yuen KY, Jin D
Department:	Microbiology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2010

Project Title:	A feasibility study on anti-H5N1 influenza viral infection using aptamers targeting viral nucleoprotein
Investigator(s):	Zheng B, Zhou J
Department:	Microbiology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	11/2011

Project Title:	Keystone Symposia: Frontiers in HIV Pathogenesis, Therapy and Eradication (X8) In vitro selection of HIV-1 CRF08_BC resistant variants to reverse transcriptase inhibitors
Investigator(s):	Zheng B
Department:	Microbiology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2012
Completion Date:	03/2012

Project Title:	Development of Antiviral Agents based on Small RNA Containing Unique Motif (UIM/215)
Investigator(s):	Zheng B, Zhou J
Department:	Microbiology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	05/2012

Project Title:	Development of Antiviral Agents based on Small RNA Containing Unique Motif (UIM/215)
Investigator(s):	Zheng B, Zhou J
Department:	Microbiology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	05/2012

Project Title:	Development of Antiviral Agents based on Small RNA Containing Unique Motif
Investigator(s):	Zheng B, Zhou J
Department:	Microbiology
Source(s) of Funding:	Matching Grant for Joint Research
Start Date:	05/2012

List of Research Outputs

Researcher : Zhou J

Project Title:	A feasibility study on the inhibition of respiratory syncytial virus infection using siRNAs with a unique motif
Investigator(s):	Zhou J, Zheng B
Department:	Microbiology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2010

Project Title:	A feasibility study on the inhibition of respiratory syncytial virus infection using siRNAs with a unique motif
Investigator(s):	Zhou J, Zheng B
Department:	Microbiology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2011

Project Title:	Characterization of KLF15 as a crucial transactivator for hepatitis B virus gene expression and viral replication in vitro and in vivo
Investigator(s):	Zhou J, Yuen KY, Zheng B
Department:	Microbiology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2012

List of Research Outputs

Lei T., Siu K.L., Kok K.H., Chan K.H., Chan E.Y.T., Hung I.F.N., To K.K.W., Li P.C.K., Zhou J., Zheng B., Yuen K.Y., Wang M. and Jin D., Anti-ganglioside antibodies were not detected in human subjects infected with or vaccinated against 2009 pandemic influenza A (H1N1) virus., Vaccine. 2012, 30: 2605-2610.

Zhou J., Tan T., Tian Y., Zheng B., Ou J.H., Huang E.J. and Yen T.S., Krüppel-like factor 15 activates hepatitis B virus gene expression and replication, Hepatology. Hepatology, 2011, 54: 109-21.

Researcher : Zhu H

List of Research Outputs

Lam T.Y., Zhu H., Wang J., Smith D.K., Holmes E.C., Webster R.G., Webby R., Peiris J.S.M. and Guan Y., Reassortment Events Among Swine Influenza A Viruses in China: Implications for the Origin of the 2009 Influenza Pandemic, J Virol. 2011, 85(19): 10279-85.

Lessler J., Cummings D.A.T., Read J.M., Wang S., Zhu H., Smith G.J., Guan Y., Jiang C. and Riley S., Location-specific patterns of exposure to recent pre-pandemic strains of influenza A in southern China, Nat Commun. 2011, 2:423: doi:10.1038/ncomms1432.

Liu Y., Cao M., Zhu H. and Guan Y., Detection and Phylogenetic Analysis of Coronavirus from Ducks and Chickens in Southern China., 49th Infectious Diseases Society of America (IDSA) Annual Meeting. 2011.

Zhu H., Li L., Zeng Y., Zhou J., Zheng Z., Chen R., Zheng R., Duan L., Yip C.H., Huang K., Lam T.Y., Wang J., Chen H., Webster R.G., Webby R., Peiris J.S.M., Smith D.K. and Guan Y., Pandemic H1N1/2009 virus in swine: prevalence and genesis of reassortants with the potential to infect humans., 4th International Influenza Conference: Influenza2011 Zoonotic Influenza and Human Health. 2011.

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