DEPT OF PHARMACOLOGY



Researcher : Bai B

List of Research Outputs

Bai B., Liang Y., Xu C., Xu A.M., Kee M., Vanhoutte P.M.G.R. and Wang Y., CDK5 mediates SIRT1 phosphorylation at serine 47 during endothelial senescence, 16th Research Postgraduate Symposium, December 7-8, 2011 Hong Kong. 2011, 2.01.
Bai B., Liang Y., Xu C., Lee M.Y.K., Xu A., Wu D., Vanhoutte P.M.G.R. and Wang Y., CDK5-Mediated Hyperphosphorylation of SIRT1 Contributes to the Development of Endothelial Senescence and Atherosclerosis, Circulation. 2012.
Bai B., Vanhoutte P.M.G.R. and Wang Y., CDK5-mediated phosphorylation of SIRT1 at serine 47 contributes to the development of endothelial senescence, XVI International Symposium on Atherosclerosis, Sydney, Australia, 25-29 March, 2012. 64.
Lee M.Y.K., Cai Y., Wang Y., Liao S., Liu Y., Zhang Y., Bai B., Tse H.F. and Vanhoutte P.M.G.R., Differential genomic changes caused by cholesterol - and PUFA-rich diets in regenerated porcine coronary endothelial cells, Physiolgical Genomics. 2012, 44: 551-561.
Radjainia H., Huang B., Bai B., Schmitz M., Wang Y. and Mitra A., A highly conserved tryptophan in the N-terminal variable domain regulates rate of disulfide bond formation and oligomeric assembly of adiponectin., FEBS Journal. 2012.


Researcher : Baretella OM

List of Research Outputs

Baretella O.M., Li F.Y.L., Chung S.K. and Vanhoutte P.M.G.R., Reduction of contractions to phenylephrine by L-NAME in the carotid artery of mice with endothelial overexpression of endothelin-1, Experimental Biology 2012, April 21 - 25, 2012, San Diego, CA . 2012.


Researcher : Cai Y

List of Research Outputs

Cai Y., Vanhoutte P.M.G.R. and Tang E.H.C., Knockdown of Rap 1 Suppresses NF-kB-dependent inflammation in Human Macrophages, 17th Research Postgraduate Symposium, Hong Kong, December 12 & 13, 2012. 85.
Cai Y., Liang Y., Lee M.Y.K., Vanhoutte P.M.G.R., Wang Y. and Wang Y., MMP-7 in the development of endothelial dysfunctions and atherosclerosis, EDHF 2012 - 10TH Anniversary Meeting, Vaux-de-Cernay, France, June 27-30, 2012 . 2012, 10.
Cai Y., Leung G.P.H. and Vanhoutte P.M.G.R., Thyroid hormone affects both endothelial and vascular smooth muscle cells in rat arteries, Experimental Biology 2012, April 21-25, San Diego, CA. 2012, 189.
Lee M.Y.K., Cai Y., Wang Y., Liao S., Liu Y., Zhang Y., Bai B., Tse H.F. and Vanhoutte P.M.G.R., Differential genomic changes caused by cholesterol - and PUFA-rich diets in regenerated porcine coronary endothelial cells, Physiolgical Genomics. 2012, 44: 551-561.


Researcher : Cai Y

List of Research Outputs

Cai Y., Vanhoutte P.M.G.R. and Tang E.H.C., Knockdown of Rap 1 Suppresses NF-kB-dependent inflammation in Human Macrophages, 17th Research Postgraduate Symposium, Hong Kong, December 12 & 13, 2012. 85.
Cai Y., Liang Y., Lee M.Y.K., Vanhoutte P.M.G.R., Wang Y. and Wang Y., MMP-7 in the development of endothelial dysfunctions and atherosclerosis, EDHF 2012 - 10TH Anniversary Meeting, Vaux-de-Cernay, France, June 27-30, 2012 . 2012, 10.
Cai Y., Leung G.P.H. and Vanhoutte P.M.G.R., Thyroid hormone affects both endothelial and vascular smooth muscle cells in rat arteries, Experimental Biology 2012, April 21-25, San Diego, CA. 2012, 189.
Lee M.Y.K., Cai Y., Wang Y., Liao S., Liu Y., Zhang Y., Bai B., Tse H.F. and Vanhoutte P.M.G.R., Differential genomic changes caused by cholesterol - and PUFA-rich diets in regenerated porcine coronary endothelial cells, Physiolgical Genomics. 2012, 44: 551-561.


Researcher : Chan HK

List of Research Outputs

Lam J.K.W., Liang W. and Chan H.K., Pulmonary delivery of therapeutic siRNA, Advanced Drug Delivery Reviews. 2012, 64 (1): 1-15.


Researcher : Chan KYC

List of Research Outputs

Chan K.Y.C., Mak J.C.W., Gao Y.S., Man R.Y.K. and Vanhoutte P.M.G.R., Endothelium-derived NO, but not cyclic GMP, is required for hypoxic augmentation in isolated porcine coronary arteries, American Journal of Physiology - Heart and Circulatory Physiology. 2011, 301: H2313-H2321.
Zhao Y., Chan K.Y.C., Liao S., Tse H.F., Leung S.W.S., Xu A. and Vanhoutte P.M.G.R., Apocynin and BMS309403 reduce dysfunction of regenerated endothelium of the pig coronary artery, Seventh International Symposium on Healthy Aging of the Research Centre of Heart, Brain, Hormone and Healthy Aging, March 3-4, 2012, Hong Kong. 2012, 70.


Researcher : Chan KYC

List of Research Outputs

Chan K.Y.C., Mak J.C.W., Gao Y.S., Man R.Y.K. and Vanhoutte P.M.G.R., Endothelium-derived NO, but not cyclic GMP, is required for hypoxic augmentation in isolated porcine coronary arteries, American Journal of Physiology - Heart and Circulatory Physiology. 2011, 301: H2313-H2321.
Zhao Y., Chan K.Y.C., Liao S., Tse H.F., Leung S.W.S., Xu A. and Vanhoutte P.M.G.R., Apocynin and BMS309403 reduce dysfunction of regenerated endothelium of the pig coronary artery, Seventh International Symposium on Healthy Aging of the Research Centre of Heart, Brain, Hormone and Healthy Aging, March 3-4, 2012, Hong Kong. 2012, 70.


Researcher : Chan MLY

List of Research Outputs

Leung S.W.S., Chan M.L.Y., Man G.S.K. and Man R.Y.K., Ovariectomy promotes the enhancement of endothelium-derived hyperpolarizing factor-mediated relaxation in mesenteric arteries of rats with chronic nitric oxide synthase inhibition, Fifteenth Annual Scientific Meeting of The Institute of Cardiovascular Science and Medicine, September 17, 2011 Hong Kong, 2011, 15. 2011, 15.


Researcher : Chan WYE

Project Title:Pharmacoepidmiology study of medication errors
Investigator(s):Chan WYE, Wong ICK
Department:Pharmacology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012


List of Research Outputs

Chan W.Y.E., Chan EW, Knott JC, Liew D, Taylor DMcD, Kong DCM. The pharmacoeconomics of managing acute agitation in the Emergency Department: what do we know and how do we approach it?, Exp Rev Pharmacoeconomics. 2012, 12(5): 589-595.


Researcher : Chen J

List of Research Outputs

Chow H.M., Liu J., Sun R.W.Y., Vanhoutte P.M.G.R., Xu A., Chen J., Che C.M. and Wang Y., The gold (III) porphyrin complex, gold-2a, supresses WNT1 expression in breast cancer cells by enhancing the promoter association of YY1, American Journal of Translational Research. 2011, 3: 479-491.
Liu J., Xu A., Lam K.S.L., Wong N.S., Chen J., Shepherd P.R. and Wang Y., Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation, 18th Hong Kong International Cancer Congress. 2011.
Liu J., Xu A., Lam K.S.L., Wong N.S., Chen J., Sheperd P.R. and Wang Y., Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation, The 18th Hong Kong International Cancer Conference. 2011.
Liu J., Xu A., Lam K.S.L., Wong N.S., Chen J., Shepherd P.R. and Wang Y., Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation, The 18th Hong Kong International Cancer Conference. 2011.


Researcher : Cho CH

Project Title:Advances in GI Pharmacology - From Acid Secretion to Mucosal Protection Symposium Non-ulcerogenic Dose of Dexamethasone Delays Gastric Ulcer Healing in Rats
Investigator(s):Cho CH
Department:Pharmacology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:11/2004


Project Title:Adrenaline and its receptor activation on colon cancer growth
Investigator(s):Cho CH
Department:Pharmacology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:02/2006




Researcher : Chow HM

List of Research Outputs

Chow H.M., Liu J., Sun R.W.Y., Vanhoutte P.M.G.R., Xu A., Chen J., Che C.M. and Wang Y., The gold (III) porphyrin complex, gold-2a, supresses WNT1 expression in breast cancer cells by enhancing the promoter association of YY1, American Journal of Translational Research. 2011, 3: 479-491.


Researcher : Chui WCM

List of Research Outputs

Samaranayake N.R., Chui W.C.M. and Cheung B.M.Y., Medication incidents related to technology in a university-affiliated general hospital in 2006-2010, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 44.
Samaranayake N.R., Cheung S.T.D., Chui W.C.M. and Cheung B.M.Y., Reducing the use of inappropriate abbreviations in prescriptions, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 45.
Samaranayake N.R., Cheung S.T.D., Chui W.C.M. and Cheung B.M.Y., Reducing the use of inappropriate abbreviations in prescriptions, Presented at the International Medication Safety Conference, Hong Kong 2011.
Samaranayake N.R., Cheung S.T.D., Chui W.C.M. and Cheung B.M.Y., The pattern of non-intercepted medication errors in a university affiliated teaching hospital, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 44.


Researcher : Fan P

List of Research Outputs

Fan P. and Wang Y., Adipokines-Toward the Molecular Dissection of Interactions between Stromal Adipocytes and Breast Cancer Cells, Breast Cancer Cells/Book 5. InTech press, 2011.
Fan P., Song E., Xu A., Feletou M., Vilaine J.P., Vanhoutte P.M.G.R. and Huang Y., Elevated 20-Hete contributes to the improved endothelial function in lipocalin-2 deficient mice, EDHF 2012 - 10TH Anniversary Meeting, Vaux-de-Cernay, France, June 27-30, 2012 . 2012, 16.
Song E., Fan P., Xu A., Vanhoutte P.M.G.R. and Wang Y., Lipocalin-2 mediates linoleic acid-induced endothelial dysfunction, Experimental Biology 2012, April 21-25, San Diego, CA. 2012, 259, 840.9.
Yang B., Fan P., Xu A., Lam K.S.L., Berger T., Mak T., Tse H.F., Song E., Vanhoutte P.M.G.R. and Wang Y., Improved functional recovery to I/R injury in hearts from lipocalin-2 deficiency mice: Restoration of Mitochondrial Function and Phospholipids Remodeling., American Journal of Translational Research. 2012.
Yang B., Fan P., Xu A., Lam K.S.L., Berger T., Mak T.W., Tse H.F., Yue W., Song E., Vanhoutte P.M.G.R., Sweeney G. and Wang Y., Improved functional recovery to I/R injury in hearts from lipocalin-2 deficiency mice: restoration of mitochondrial function and phospholipids remodeling, Am J Transl Res. 2012, 4(1): 60-71.


Researcher : Ho YW

List of Research Outputs

Li R.W.S., Yang C., Sit S.M., Lin Y.T., Ho Y.W. and Leung G.P.H., Physiological and Pharmacological roles of Vascular Nucleoside Transporters, J Cardiovasc Pharmacol. 2012, 59: 10-15.
Li R.W.S., Yang C., Sit S.M., Lin Y.T., Ho Y.W. and Leung G.P.H., Physiological and Pharmacological roles of vascular nucleoside transporters., Journal of Cardiovascular Pharmacology . 2012, 59: 10-15.


Researcher : Huang B

List of Research Outputs

Liu T.C., Song E., Xu A., Berger T., Mak T., Tse H.F., Law K.M., Huang B., Vanhoutte P.M.G.R. and Wang Y., Lipocalin-2 deficiency prevents endothelial dysfunction associated with dietary obesity: role of cytochrome P450 2C inhibition., British Journal of Pharmacology. 2011.
Radjainia H., Huang B., Bai B., Schmitz M., Wang Y. and Mitra A., A highly conserved tryptophan in the N-terminal variable domain regulates rate of disulfide bond formation and oligomeric assembly of adiponectin., FEBS Journal. 2012.
Wang Y., Huang B., Song E., Xu A., Feletou M. and Vilaine J.P., Obesity-accelerated arterial aging: interplay between free fatty acids and lipocalin-2, EDHF 2012 - 10th Anniversary Meeting, Vaux-de-Cernay, France, June 27-30, 2012. 49.
Zhou M., Xu A., Tam P.K.H., Lam K.S.L., Huang B., Liang Y., Lee I.K., Wu D.H. and Wang Y., Upregulation of UCP2 by adiponectin: the involvement of mitochondrial superoxide and hnRNP K, PLoS One. 2012, 7(2): e32349.


Researcher : Keung WYW

List of Research Outputs

Keung W.Y.W. and Man R.Y.K., Circulating sex hormones modulate vascular contractions and acute response to 17b-estradiol in rat mesenteric arteries, Pharmacology. 2011, 88: 55-64.


Researcher : Kong WCB

List of Research Outputs

Kong W.C.B., Lo C. and Leung S.W.S., The health status of endothelium in aging and hypertension , Chinese Journal of Pharmacology and Toxicology, HKPS / CPS Jointly Meeting, September 23-25, 2011 Jinan, China, 2011, 136. 2011.


Researcher : Koo MWL

Project Title:A cell-base co-culture system for the evaluation of green tea catechin, epigallocatechin gallate, in insulin resistance
Investigator(s):Koo MWL
Department:Pharmacology
Source(s) of Funding:Small Project Funding
Start Date:01/2009




Researcher : Kwan YW

List of Research Outputs

Kwan Y.W., Leung S.W.S. and Man R.Y.K., 1,25-Dihydroxyvtamin D3 acutely reduces acetylcholine-induced endothelium-dependent contraction in hypertensive rat aorta through activation of protein kinase C, EDHF 2012 - 10TH Anniversary Meeting, Vaux-de-Cernay, France, June 27-30, 2012 . 2012, 30.
Kwan Y.W., EPAC-Selective cyclic AMP analog, 8-PCPT-2'-O-ME-CAMP, induced relaxation in the porcine coronary artery in a RAP1-Independent mechanism, Fifteen Annual Scientific Meeting of The Institute of Cardiovascular Science and Medicine, September 17, 2011 Hong Kong. 2011, 14.
Kwan Y.W., Leung S.W.S. and Man R.Y.K., EPAC1 induces vasodilation on porcine coronary artery smooth muscle by Rho kinase I nhibition in a RAP1-independent pathway, Seventh International Symposium on Healthy Aging of the Research Centre of Heart, Brain, Hormone and Healthy Aging, March 3-4, 2012 Hong Kong. 2012, 50.
Kwan Y.W., Leung S.W.S. and Man R.Y.K., Epac-selective cyclic-AMP analog, 8-pCPT-2'-O-Me-cAMP, Induced Vasodilation in Porcine Coronary Artery by Rap1-independent Manner, 16th Research Postgraduate Symposium, December 7-8, 2011 Hong Kong. 2011, 2.10.
Kwan Y.W., Leung S.W.S. and Man R.Y.K., Epac1-selective cyclic-AMP analog 8-pCPT-2'-O-Me-cAMP induces vasodilation on porcine coronary artery in endothelium-independent pathway, BPS Winter Meeting London 2011, December 13-15. 2011, P041.


Researcher : Kwok PCL

Project Title:Inhalable dry powder aerosols for influenza prevention or treatment
Investigator(s):Kwok PCL, Yen H, Peiris JSM
Department:Pharmacology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2012


Project Title:Respiratory Drug Delivery 2012 Arizona Spray freeze dried large porous particles for nano drug delivery by inhalation
Investigator(s):Kwok PCL
Department:Pharmacology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:05/2012


List of Research Outputs

Chan H.-.K., Young P.M., Traini D., Kwok P.C.L. and Chan J.G.Y., Inhalable compositions, WO/2012/058719. 2012.
D'Addio S.M., Chan J.G.Y., Kwok P.C.L., Prud'homme R.K. and Chan H.-.K., Constant size, variable density aerosol particles by ultrasonic spray freeze drying, In: A.T. Florence, D.J. Burgess, T. Sonobe, J. Siepmann, International Journal of Pharmaceutics. Elsevier, 2012, 427: 185-191.
D'Addio S.M., Chan J.G.Y., Kwok P.C.L., Prud'homme R.K. and Chan H.-.K., Spray freeze dried large porous particles for nano drug delivery by inhalation, In: RN Dalby, PR Byron, J Peart, JD Suman, SJ Farr, PM Young, Respiratory Drug Delivery 2012, Phoenix, AZ, USA. River Grove, IL, Davis Healthcare International Publishing, 2012, 3: 695-698.
Kwok P.C.L., Novel dry powder formulations for pulmonary drug delivery, 7th AAPS-NUS PharmSci@Asia Symposium, National University of Singapore, Singapore. 2012, 21.
Kwok P.C.L., Novel dry powder formulations for pulmonary drug delivery, 用於呼吸系统药物传递的新型干粉吸入剂, China Pharmaceutical University, Nanjing, China, 29 May 2012. 2012.
Yamasaki K., Kwok P.C.L., Fukushige K., Prud'homme R.K. and Chan H.-.K., Enhanced dissolution of inhalable cyclosporine nano-matrix particles with mannitol as matrix former, International Journal of Pharmaceutics. 2011, 420: 34-42.


Researcher : Lam JKW

Project Title:Investigation of siRNA delivery to macrophages: potential novel therapy for the treatment of tuberculosis
Investigator(s):Lam JKW, Yam WC
Department:Pharmacology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:03/2011


Project Title:The investigation of antimicrobial peptide as novel therapy for mycobacterium tuberculosis
Investigator(s):Lam JKW, Yam WC
Department:Pharmacology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Mini Grants
Start Date:10/2011


Project Title:Chitosan-based dry powder nasal formulation for delivering therapeutic peptides – development of technology platform for intranasal delivery study
Investigator(s):Lam JKW, Kwok PCL
Department:Pharmacology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2012


Project Title:12th European Symposium on Controlled Drug Delivery Delivery of siRNA to lung epithelial cells and macrophages using pH responsive amphipathic peptide
Investigator(s):Lam JKW
Department:Pharmacology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:04/2012
Completion Date:04/2012


List of Research Outputs

Lam J.K.W., Liang W., Lan Y., Chaudhuri P., Chow M.Y.T., Witt K., Kudsiova L. and Mason A.J., Effective endogenous gene silencing mediated by pH responsive peptides proceeds via multiple pathways, Journal of Controlled Release. 2011, 158: 293-303.
Lam J.K.W., Nucleic acid and peptide-based therapy - barriers and potentials for infectious diseases, AoE Research Seminar, Control of Pandemic and Inter-Pandemic Influenza, LKS Faculty of Medicine, The University of Hong Kong. 2012.
Lam J.K.W., Liang W. and Chan H.K., Pulmonary delivery of therapeutic siRNA, Advanced Drug Delivery Reviews. 2012, 64 (1): 1-15.
Lam J.K.W., The delivery and formulation of therapeutic nucleic acids and peptides against respiratory infectious diseases, Pharmaceutical Science Division, King's College London. 2012.
Lam J.K.W. and Liang W., The delivery of therapeutic siRNA using pH responsive peptides - potential for the treatment of infectious diseases, Novel Drug Discovery, Joint Conference of World Class University (between CBNU & Harvard Medical School). 2012.
Lam J.K.W., The delivery of therapeutic siRNA using pH sensitive peptides - potential for the treatment of infectious diseases, Novel Drug Discovery, Joint Conference of World Class University (between CNBU & Harvard Medical School). 2012.
Lam J.K.W., The potential and barriers of siRNA and peptide-based therapeutics therapeutics against infectious diseases, Department of BIN Fusion, Chonbuck National University, Korea. 2012.
Lan Y., Liang W., Mason A.J. and Lam J.K.W., Delivery of siRNA to lung epithelial cells and macrophages using pH-responsive amphipathic peptides, 12th European Symposium on Controlled Drug Delivery. 2012.
Liang W., Lan Y., Mason J. and Lam J.K.W., The investigation of pH responsive amphipathic peptide for gene silencing , AAPS-NUS 7th PharmSci@Asia Symposium - Exploring Pharmaceutical & Opportunities, 6th & 7th June 2012 Singapore. 2012, 40.


Researcher : Lam MPS

List of Research Outputs

Lam M.P.S. and Cheung B.M.Y., The Pharmacogenetics of the Response to Warfarin in Chinese, Br J Clin Pharmacol. 2012, 73: 340-7.
Lam M.P.S. and Cheung B.M.Y., The use of STOPP/START criteria as a screening tool for assessing the appropriateness of medications in the elderly population, Expert Rev Clin Pharmacol. 2012, 5: 187-97.


Researcher : Lan Y

List of Research Outputs

Lam J.K.W., Liang W., Lan Y., Chaudhuri P., Chow M.Y.T., Witt K., Kudsiova L. and Mason A.J., Effective endogenous gene silencing mediated by pH responsive peptides proceeds via multiple pathways, Journal of Controlled Release. 2011, 158: 293-303.
Lan Y., Liang W., Mason A.J. and Lam J.K.W., Delivery of siRNA to lung epithelial cells and macrophages using pH-responsive amphipathic peptides, 12th European Symposium on Controlled Drug Delivery. 2012.
Liang W., Lan Y., Mason J. and Lam J.K.W., The investigation of pH responsive amphipathic peptide for gene silencing , AAPS-NUS 7th PharmSci@Asia Symposium - Exploring Pharmaceutical & Opportunities, 6th & 7th June 2012 Singapore. 2012, 40.


Researcher : Law KM

List of Research Outputs

Liu T.C., Song E., Xu A., Berger T., Mak T., Tse H.F., Law K.M., Huang B., Vanhoutte P.M.G.R. and Wang Y., Lipocalin-2 deficiency prevents endothelial dysfunction associated with dietary obesity: role of cytochrome P450 2C inhibition., British Journal of Pharmacology. 2011.


Researcher : Lee MYK

List of Research Outputs

Bai B., Liang Y., Xu C., Lee M.Y.K., Xu A., Wu D., Vanhoutte P.M.G.R. and Wang Y., CDK5-Mediated Hyperphosphorylation of SIRT1 Contributes to the Development of Endothelial Senescence and Atherosclerosis, Circulation. 2012.
Cai Y., Liang Y., Lee M.Y.K., Vanhoutte P.M.G.R., Wang Y. and Wang Y., MMP-7 in the development of endothelial dysfunctions and atherosclerosis, EDHF 2012 - 10TH Anniversary Meeting, Vaux-de-Cernay, France, June 27-30, 2012 . 2012, 10.
Lee M.Y.K., Cai Y., Wang Y., Liao S., Liu Y., Zhang Y., Bai B., Tse H.F. and Vanhoutte P.M.G.R., Differential genomic changes caused by cholesterol - and PUFA-rich diets in regenerated porcine coronary endothelial cells, Physiolgical Genomics. 2012, 44: 551-561.


Researcher : Leung GPH

Project Title:Cloning and characterization of novel equilibrative nucleoside transporter type 4 (ENT4)
Investigator(s):Leung GPH
Department:Pharmacology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:03/2005


Project Title:Abacavir, an antiviral nucleoside analogue, increases the risk of cardiovascular events by causing endothelial dysfunction
Investigator(s):Leung GPH, Vanhoutte PMGR, Xia Z
Department:Pharmacology
Source(s) of Funding:General Research Fund (GRF)
Start Date:11/2009


Project Title:Protective effect of ergothioneine on endothelial cell function against oxidative stress
Investigator(s):Leung GPH, Xia Z
Department:Pharmacology
Source(s) of Funding:General Research Fund (GRF)
Start Date:11/2010


Project Title:Re-uptake system of epoxyeicosatrienoic acids in vascular cells
Investigator(s):Leung GPH
Department:Pharmacology
Source(s) of Funding:Small Project Funding
Start Date:03/2011


Project Title:Inhibitory effect of emodin on nucleoside transporters: potential implication in cancer therapy
Investigator(s):Leung GPH
Department:Pharmacology
Source(s) of Funding:Small Project Funding
Start Date:04/2012


Project Title:BPS Focused Meeting on Neuropeptides Age and testosterone-dependent change in the expression of calcitonin-gene related peptide receptors in rat basilar arteries
Investigator(s):Leung GPH
Department:Pharmacology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2012
Completion Date:06/2012


List of Research Outputs

Cai Y., Leung G.P.H. and Vanhoutte P.M.G.R., Thyroid hormone affects both endothelial and vascular smooth muscle cells in rat arteries, Experimental Biology 2012, April 21-25, San Diego, CA. 2012, 189.
Hu G., Siu S.O., Li S., Chu I.K., Kwan Y.W., Chan S.W., Leung G.P.H., Yan R. and Lee S.M.Y., Metabolism of calycosin, an isoflavone from Astragali Radix, in zebrafish larvae, Xenobiotica . 2012, 42: 294-303.
Leung G.P.H., Iatrogenic mitochondriopathies: a recent lesson from nucleoside/nucleotide reverse transcriptase inhibitors, Advances in experimental medicine and biology . 2012, 942: 347-369.
Leung G.P.H., Protective effect of ergothioneine on endothelial cell function against oxidative stress, International Society of Chinese Medicine, Macau. 2011.
Li R.W.S., Yang C., Sit S.M., Lin Y.T., Ho Y.W. and Leung G.P.H., Physiological and Pharmacological roles of Vascular Nucleoside Transporters, J Cardiovasc Pharmacol. 2012, 59: 10-15.
Li R.W.S., Yang C., Sit S.M., Lin Y.T., Ho Y.W. and Leung G.P.H., Physiological and Pharmacological roles of vascular nucleoside transporters., Journal of Cardiovascular Pharmacology . 2012, 59: 10-15.
Li S., Lou S., Lei B.U.W., Chan T.F., Kwan Y.W., Chan S.W., Leung G.P.H., Tsui S.K.W. and Lee S.M.Y., Transcriptional Profiling of Angiogenesis Activities of Calycosin in Zebrafish, Molecular BioSystems. 2011, 7: 3112-3121.
Lin Y.T., Li R.W.S., Sit S.M., Kwan Y.W. and Leung G.P.H., Effects of emodin on nucleside transporters in endothelial cells, 16th Research Postgraduate Symposium, December 7-8, 2011 Hong Kong. 2011, 2.17.
Lin Y.T., Li R.W.S., Sit S.M., Kwan Y.W. and Leung G.P.H., Inhibition of nucleoside transporters in endothelial cells by emodin, Fifteenth Annual Scientific Meeting of The Institute of Cardiovascular Science and Medicine, September 17, 2011 Hong Kong. 2011, 9.
Lin Y.T., Li R.W.S., Zhang Y., Kwan Y.W. and Leung G.P.H., Inhibitory effect of emodin on human equilibrative nucleoside transporters and its potertial implication in enhancing the anti-cancer activity of gemcitabine, 19th Wonca Asia Pacific regional Conference, May 24-27, 2012 Jeju, Korea. 2012, PP24-72.
Zhang Y., Sze C.W., Tong Y., Song J., Lee C.K.F., Leung G.P.H., Ng T.B. and Shaw P.C., Anti-parkinsonian drug discovery from herbal medicines: what have we got from neurotoxic models. , In: Song JX, Stephen Sze CW, Ng TB, Caivin Lee KF, George Leung PH, Shaw PC, Tong Y, Zhang YB*., Journal of Ethnopharmacology. 2012 Feb 15; 139(3): 698-711. . 2012, 139: 698-711.
Zhang Y., Sze C.W., Tong Y., Cai Y., Liu J., Lee C.K.F. and Leung G.P.H., Comparative Analysis of Caffeoylquinic Acids and Lignans in Roots and Seeds among Various Burdock (Arctium lappa) Genotypes with High Antioxidant Activity., In: Liu JY, Cai YZ, Wong RNS, Lee KF, Tang CY, Sze CW, Tong Y and Zhang YB*. , J Agri Food Chem. 2012 April, 60 (16): 4067–75. . 2012, 60: 4067–75.
Zhang Y., Hu G., Li S., Li Z.H., Lam C.O., Hong S.J., Kwan Y.W., Chan S.W., Leung G.P.H. and Lee S.M.Y., Pro-angiogenic activity of astragaloside IV in HUVECs in vitro and zebrafish in vivo, Molecular Medicine Report. 2012, 5: 805-811.


Researcher : Leung SWS

Project Title:Acceleration of the senescence of the endothelium by high blood pressure
Investigator(s):Leung SWS, Lee MYK, Vanhoutte PMGR
Department:Pharmacology
Source(s) of Funding:General Research Fund (GRF)
Start Date:11/2008
Completion Date:10/2011


Project Title:Nitric oxide signaling pathway involved in the inhibition of the release of endothelium-derived contracting factor in hypertension
Investigator(s):Leung SWS
Department:Pharmacology
Source(s) of Funding:Travel Grants for NSFC/RGC JRS
Start Date:12/2009


Project Title:Assessment of vascular reactivity in protease inhibitor treatment using a rat model
Investigator(s):Leung SWS, Vanhoutte PMGR
Department:Pharmacology
Source(s) of Funding:Small Project Funding
Start Date:02/2011
Completion Date:08/2012


Project Title:Vascular effects of milk casein
Investigator(s):Leung SWS
Department:Pharmacology
Source(s) of Funding:Small Project Funding
Start Date:06/2012


Project Title:EDHF 2012 ANTIRETROVIRAL TREATMENT CAN AFFECT THE RELEASE OF NO AND EDCF, BUT NOT EDH IN RAT ARTERIES
Investigator(s):Leung SWS
Department:Pharmacology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2012


List of Research Outputs

Kong W.C.B., Lo C. and Leung S.W.S., The health status of endothelium in aging and hypertension , Chinese Journal of Pharmacology and Toxicology, HKPS / CPS Jointly Meeting, September 23-25, 2011 Jinan, China, 2011, 136. 2011.
Kwan Y.W., Leung S.W.S. and Man R.Y.K., 1,25-Dihydroxyvtamin D3 acutely reduces acetylcholine-induced endothelium-dependent contraction in hypertensive rat aorta through activation of protein kinase C, EDHF 2012 - 10TH Anniversary Meeting, Vaux-de-Cernay, France, June 27-30, 2012 . 2012, 30.
Kwan Y.W., Leung S.W.S. and Man R.Y.K., EPAC1 induces vasodilation on porcine coronary artery smooth muscle by Rho kinase I nhibition in a RAP1-independent pathway, Seventh International Symposium on Healthy Aging of the Research Centre of Heart, Brain, Hormone and Healthy Aging, March 3-4, 2012 Hong Kong. 2012, 50.
Kwan Y.W., Leung S.W.S. and Man R.Y.K., Epac-selective cyclic-AMP analog, 8-pCPT-2'-O-Me-cAMP, Induced Vasodilation in Porcine Coronary Artery by Rap1-independent Manner, 16th Research Postgraduate Symposium, December 7-8, 2011 Hong Kong. 2011, 2.10.
Kwan Y.W., Leung S.W.S. and Man R.Y.K., Epac1-selective cyclic-AMP analog 8-pCPT-2'-O-Me-cAMP induces vasodilation on porcine coronary artery in endothelium-independent pathway, BPS Winter Meeting London 2011, December 13-15. 2011, P041.
Kwong A.W.S., Leung S.W.S. and Man R.Y.K., Effect of isolavones on the vascular actions of phosphodiesterase inhibitors, EDHF 2012 - 10TH Anniversary Meeting, Vaux-de-Cernay, France, June 27-30, 2012 . 2012, 31.
Leung S.W.S., Chan M.L.Y., Man G.S.K. and Man R.Y.K., Ovariectomy promotes the enhancement of endothelium-derived hyperpolarizing factor-mediated relaxation in mesenteric arteries of rats with chronic nitric oxide synthase inhibition, Fifteenth Annual Scientific Meeting of The Institute of Cardiovascular Science and Medicine, September 17, 2011 Hong Kong, 2011, 15. 2011, 15.
Nejad A., Lee S.S., Vanhoutte P.M.G.R. and Leung S.W.S., Antiretroviral treatment can affect the release of NO and EDCF, but EDH in rat arteries, EDHF 2012 - 10TH Anniversary Meeting, Vaux-de-Cernay, France, June 27-30, 2012 . 2012, 37.
Ng J.K.F., Cheung C.W., Lee Y. and Leung S.W.S., Low-dose desmopressin improves hypothermia-induced impairment of primary haemostasis in healthy volunteers, Journal of the Association of Anaesthetists of Great Britain and Ireland. 2011, 66: 999-1005.
Zhang Y., Leung S.W.S. and Man R.Y.K., Effects of luteolin on endothelium-dependent relaxation is different between male and female rat mesenteric arteries: relationship with endothelium-derived hyperpolarizing factor and cyclooxygenase pathways, Fifteenth Annual Scientific Meeting of The Institute of Cardiovascular Science and Medicine, September 17, 2011 Hong Kong, 2011, 7 . 2011.
Zhang Y., Leung S.W.S. and Man R.Y.K., Gender-specific Relaxation of Flavonoids in Rat Mesenteric Arteries, 15th Research Postgraduate Symposium, Hong Kong, December 1-2, 2010. 2011, 100.
Zhang Y., Leung S.W.S. and Man R.Y.K., Gender-specific effects of luteolin in the enhancement of endothelium-dependent relaxation in 45-50 weeks old rat mesenteric arteries: role of endothelium-derived hyperpolarizing factors and cyclooxygenase, Chinese Journal of Pharmacology and Toxicology, HKPS / CPS Jointly Meeting, September 23-25, 2011 Jinan China. 2011, 25: 139.
Zhang Y., Leung S.W.S. and Man R.Y.K., Gender-specific relaxation of flavonoids in rat's mesenteric arteries, Fourth Scientific Meeting of the Asian Society for Vascular Biology, Hong Kong 20-21 November, 2010. 2011, 33.
Zhao Y., Leung S.W.S. and Vanhoutte P.M.G.R., Activation of A1-adrenergic receptors causes thromoxane-prostanoid receptor desensitization in the aorta of the spontaneously hypertensive rat, Fifteenth Annual Scientific Meeting of The Institute of Cardiovascular Science and Medicine, September 17, 2011 Hong Kong. 2011, 12.
Zhao Y., Chan K.Y.C., Liao S., Tse H.F., Leung S.W.S., Xu A. and Vanhoutte P.M.G.R., Apocynin and BMS309403 reduce dysfunction of regenerated endothelium of the pig coronary artery, Seventh International Symposium on Healthy Aging of the Research Centre of Heart, Brain, Hormone and Healthy Aging, March 3-4, 2012, Hong Kong. 2012, 70.
Zhao Y., Leung S.W.S. and Vanhoutte P.M.G.R., Endothelial NOS-Independent Release of Nitric Oxide in the Aorta of the Spontaneously Hypertensive Rat , 16th Research Postgraduate Symposium, December 7-8, 2011 Hong Kong. 2011, 95, 2.32.
Zhao Y., Leung S.W.S. and Vanhoutte P.M.G.R., Endothelial NOS-independent release of nitric oxide in the aorta of the spontaneously hypertensive rat, Chinese Journal of Pharmacology and Toxicology, HKPS / CPS Jointly Meeting, September 23-25, 2011, Jinan China. 2011, 25: 140.
Zhao Y., Leung S.W.S. and Vanhoutte P.M.G.R., Endothelial NOS-independent release of nitric oxide in the aorta of the spontaneously hypertensive rat, Experimental Biology 2012, April 21-25, San Diego, CA. 2012, 259, 840.1.
Zou Q., Leung S.W.S. and Vanhoutte P.M.G.R., Activation of nicotinic receptors can contribute to endothelium-dependent relaxations to acetylcholine in the rat aorta, The Journal of Pharmacology and Expermental Therapeutics. 2012, 341: 756-763.


Researcher : Li RWS

List of Research Outputs

Li R.W.S., Yang C., Sit S.M., Lin Y.T., Ho Y.W. and Leung G.P.H., Physiological and Pharmacological roles of Vascular Nucleoside Transporters, J Cardiovasc Pharmacol. 2012, 59: 10-15.
Li R.W.S., Yang C., Sit S.M., Lin Y.T., Ho Y.W. and Leung G.P.H., Physiological and Pharmacological roles of vascular nucleoside transporters., Journal of Cardiovascular Pharmacology . 2012, 59: 10-15.
Lin Y.T., Li R.W.S., Sit S.M., Kwan Y.W. and Leung G.P.H., Effects of emodin on nucleside transporters in endothelial cells, 16th Research Postgraduate Symposium, December 7-8, 2011 Hong Kong. 2011, 2.17.
Lin Y.T., Li R.W.S., Sit S.M., Kwan Y.W. and Leung G.P.H., Inhibition of nucleoside transporters in endothelial cells by emodin, Fifteenth Annual Scientific Meeting of The Institute of Cardiovascular Science and Medicine, September 17, 2011 Hong Kong. 2011, 9.
Lin Y.T., Li R.W.S., Zhang Y., Kwan Y.W. and Leung G.P.H., Inhibitory effect of emodin on human equilibrative nucleoside transporters and its potertial implication in enhancing the anti-cancer activity of gemcitabine, 19th Wonca Asia Pacific regional Conference, May 24-27, 2012 Jeju, Korea. 2012, PP24-72.


Researcher : Li Z

List of Research Outputs

Li Z., Wang Y. and Vanhoutte P.M.G.R., Heme oxygenase-1 induction by hemin enhances EDHF-mediated relaxations in the mesenteric artery of the SHR, Fifteen Annual Scientific Meeting of The Institute of Cardiovascular Science and Medicine, September 30, 2011 Hong Kong. 2011, 8.
Li Z., Tang E.H.C., Wang Y., Man R.Y.K. and Vanhoutte P.M.G.R., Up-regulation of Heme Oxygenase-1 by Hemin Improves Endothelial Function in the Spontaneously Hypertensive Rat, 16th Research Postgraduate Symposium, December 7-8, 2011 Hong Kong. 2011, 161; 1.09.
Li Z. and Vanhoutte P.M.G.R., Up-regulation of heme oxygenase-1 improves endothelial function in the spontaneous hypertensive rat, Chinese Journal of Pharmacology and Toxicology, HKPS / CPS Joint Meeting, September 22-25, 2011 Jinan China. 2011, 25: 138.
Li Z., Wang Y. and Vanhoutte P.M.G.R., Upregulation of heme oxygenase 1 by hemin impairs endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat, Hypertension. 2011, 58: 926-934.


Researcher : Liang C

List of Research Outputs

Liang C., Man R.Y.K. and Xu A., Loss of function in toll-like receptor 4 curtails endothelial dysfunction in genetically obese mice, Fourth Scientific Meeting of the Asian Society for Vascular Biology, Hong Kong 20-21 November, 2010. 2011, 29.


Researcher : Liang W

List of Research Outputs

Lam J.K.W., Liang W., Lan Y., Chaudhuri P., Chow M.Y.T., Witt K., Kudsiova L. and Mason A.J., Effective endogenous gene silencing mediated by pH responsive peptides proceeds via multiple pathways, Journal of Controlled Release. 2011, 158: 293-303.
Lam J.K.W., Liang W. and Chan H.K., Pulmonary delivery of therapeutic siRNA, Advanced Drug Delivery Reviews. 2012, 64 (1): 1-15.
Lam J.K.W. and Liang W., The delivery of therapeutic siRNA using pH responsive peptides - potential for the treatment of infectious diseases, Novel Drug Discovery, Joint Conference of World Class University (between CBNU & Harvard Medical School). 2012.
Lan Y., Liang W., Mason A.J. and Lam J.K.W., Delivery of siRNA to lung epithelial cells and macrophages using pH-responsive amphipathic peptides, 12th European Symposium on Controlled Drug Delivery. 2012.
Liang W., Lan Y., Mason J. and Lam J.K.W., The investigation of pH responsive amphipathic peptide for gene silencing , AAPS-NUS 7th PharmSci@Asia Symposium - Exploring Pharmaceutical & Opportunities, 6th & 7th June 2012 Singapore. 2012, 40.


Researcher : Liang Y

List of Research Outputs

Bai B., Liang Y., Xu C., Xu A.M., Kee M., Vanhoutte P.M.G.R. and Wang Y., CDK5 mediates SIRT1 phosphorylation at serine 47 during endothelial senescence, 16th Research Postgraduate Symposium, December 7-8, 2011 Hong Kong. 2011, 2.01.
Bai B., Liang Y., Xu C., Lee M.Y.K., Xu A., Wu D., Vanhoutte P.M.G.R. and Wang Y., CDK5-Mediated Hyperphosphorylation of SIRT1 Contributes to the Development of Endothelial Senescence and Atherosclerosis, Circulation. 2012.
Cai Y., Liang Y., Lee M.Y.K., Vanhoutte P.M.G.R., Wang Y. and Wang Y., MMP-7 in the development of endothelial dysfunctions and atherosclerosis, EDHF 2012 - 10TH Anniversary Meeting, Vaux-de-Cernay, France, June 27-30, 2012 . 2012, 10.
Liang Y., Xu A. and Wang Y., Selective activation of AMPK in eddothelial cells intensifies high fat diet-induced non-alcoholic fatty liver disease, Journal of Hepatology of The International Liver Congress 2012, Barcelona Spain, April 18-22, 2012. 56: S493.
Liang Y., Liu L., Xu A.M., Vanhoutte P.M.G.R. and Wang Y., The lysine 64 residue of the protein kinase LKB1 is critically involved in regulating endothelial senescence by SIRT1, 16th Research Postgraduate Symposium, December 7-8, 2011 Hong Kong. 2011, 2.16.


Researcher : Lin YT

List of Research Outputs

Li R.W.S., Yang C., Sit S.M., Lin Y.T., Ho Y.W. and Leung G.P.H., Physiological and Pharmacological roles of Vascular Nucleoside Transporters, J Cardiovasc Pharmacol. 2012, 59: 10-15.
Li R.W.S., Yang C., Sit S.M., Lin Y.T., Ho Y.W. and Leung G.P.H., Physiological and Pharmacological roles of vascular nucleoside transporters., Journal of Cardiovascular Pharmacology . 2012, 59: 10-15.
Lin Y.T., Li R.W.S., Sit S.M., Kwan Y.W. and Leung G.P.H., Effects of emodin on nucleside transporters in endothelial cells, 16th Research Postgraduate Symposium, December 7-8, 2011 Hong Kong. 2011, 2.17.
Lin Y.T., Li R.W.S., Sit S.M., Kwan Y.W. and Leung G.P.H., Inhibition of nucleoside transporters in endothelial cells by emodin, Fifteenth Annual Scientific Meeting of The Institute of Cardiovascular Science and Medicine, September 17, 2011 Hong Kong. 2011, 9.
Lin Y.T., Li R.W.S., Zhang Y., Kwan Y.W. and Leung G.P.H., Inhibitory effect of emodin on human equilibrative nucleoside transporters and its potertial implication in enhancing the anti-cancer activity of gemcitabine, 19th Wonca Asia Pacific regional Conference, May 24-27, 2012 Jeju, Korea. 2012, PP24-72.


Researcher : Lin YT

List of Research Outputs

Li R.W.S., Yang C., Sit S.M., Lin Y.T., Ho Y.W. and Leung G.P.H., Physiological and Pharmacological roles of Vascular Nucleoside Transporters, J Cardiovasc Pharmacol. 2012, 59: 10-15.
Li R.W.S., Yang C., Sit S.M., Lin Y.T., Ho Y.W. and Leung G.P.H., Physiological and Pharmacological roles of vascular nucleoside transporters., Journal of Cardiovascular Pharmacology . 2012, 59: 10-15.
Lin Y.T., Li R.W.S., Sit S.M., Kwan Y.W. and Leung G.P.H., Effects of emodin on nucleside transporters in endothelial cells, 16th Research Postgraduate Symposium, December 7-8, 2011 Hong Kong. 2011, 2.17.
Lin Y.T., Li R.W.S., Sit S.M., Kwan Y.W. and Leung G.P.H., Inhibition of nucleoside transporters in endothelial cells by emodin, Fifteenth Annual Scientific Meeting of The Institute of Cardiovascular Science and Medicine, September 17, 2011 Hong Kong. 2011, 9.
Lin Y.T., Li R.W.S., Zhang Y., Kwan Y.W. and Leung G.P.H., Inhibitory effect of emodin on human equilibrative nucleoside transporters and its potertial implication in enhancing the anti-cancer activity of gemcitabine, 19th Wonca Asia Pacific regional Conference, May 24-27, 2012 Jeju, Korea. 2012, PP24-72.


Researcher : Liu J

List of Research Outputs

Chow H.M., Liu J., Sun R.W.Y., Vanhoutte P.M.G.R., Xu A., Chen J., Che C.M. and Wang Y., The gold (III) porphyrin complex, gold-2a, supresses WNT1 expression in breast cancer cells by enhancing the promoter association of YY1, American Journal of Translational Research. 2011, 3: 479-491.
Liu J., Xu A., Lam K.S.L., Wong N.S., Chen J., Shepherd P.R. and Wang Y., Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation, 18th Hong Kong International Cancer Congress. 2011.
Liu J., Xu A., Lam K.S.L., Wong N.S., Chen J., Sheperd P.R. and Wang Y., Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation, The 18th Hong Kong International Cancer Conference. 2011.
Liu J., Xu A., Lam K.S.L., Wong N.S., Chen J., Shepherd P.R. and Wang Y., Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation, The 18th Hong Kong International Cancer Conference. 2011.


Researcher : Liu J

List of Research Outputs

Chow H.M., Liu J., Sun R.W.Y., Vanhoutte P.M.G.R., Xu A., Chen J., Che C.M. and Wang Y., The gold (III) porphyrin complex, gold-2a, supresses WNT1 expression in breast cancer cells by enhancing the promoter association of YY1, American Journal of Translational Research. 2011, 3: 479-491.
Liu J., Xu A., Lam K.S.L., Wong N.S., Chen J., Shepherd P.R. and Wang Y., Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation, 18th Hong Kong International Cancer Congress. 2011.
Liu J., Xu A., Lam K.S.L., Wong N.S., Chen J., Sheperd P.R. and Wang Y., Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation, The 18th Hong Kong International Cancer Conference. 2011.
Liu J., Xu A., Lam K.S.L., Wong N.S., Chen J., Shepherd P.R. and Wang Y., Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation, The 18th Hong Kong International Cancer Conference. 2011.


Researcher : Liu TC

List of Research Outputs

Liu T.C., Song E., Xu A., Berger T., Mak T., Tse H.F., Law K.M., Huang B., Vanhoutte P.M.G.R. and Wang Y., Lipocalin-2 deficiency prevents endothelial dysfunction associated with dietary obesity: role of cytochrome P450 2C inhibition., British Journal of Pharmacology. 2011.


Researcher : Lo C

List of Research Outputs

Kong W.C.B., Lo C. and Leung S.W.S., The health status of endothelium in aging and hypertension , Chinese Journal of Pharmacology and Toxicology, HKPS / CPS Jointly Meeting, September 23-25, 2011 Jinan, China, 2011, 136. 2011.


Researcher : Man GSK

List of Research Outputs

Leung S.W.S., Chan M.L.Y., Man G.S.K. and Man R.Y.K., Ovariectomy promotes the enhancement of endothelium-derived hyperpolarizing factor-mediated relaxation in mesenteric arteries of rats with chronic nitric oxide synthase inhibition, Fifteenth Annual Scientific Meeting of The Institute of Cardiovascular Science and Medicine, September 17, 2011 Hong Kong, 2011, 15. 2011, 15.


Researcher : Man RYK

Project Title:Outstanding Research Student Supervisor Award 2007-2008
Investigator(s):Man RYK
Department:Pharmacology
Source(s) of Funding:Outstanding Research Student Supervisor Award
Start Date:10/2008


Project Title:Protective effects of vitamin D on endothelial dysfunction in hypertension
Investigator(s):Man RYK, Leung SWS, Vanhoutte PMGR
Department:Pharmacology
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2010


Project Title:Effects of different isoflavones on the activity of phosphodiesterase (PDE) in porcine coronary artery
Investigator(s):Man RYK, Leung SWS
Department:Pharmacology
Source(s) of Funding:Small Project Funding
Start Date:12/2010
Completion Date:05/2012


Project Title:Peroxisome Proliferator-Activated Receptors and Vascular Function
Investigator(s):Man RYK, Leung SWS, Vanhoutte PMGR
Department:Pharmacology
Source(s) of Funding:General Research Fund (GRF)
Start Date:12/2011


Project Title:Involvement of cyclooxygenase pathway in the vascular actions of estrogen
Investigator(s):Man RYK, Leung SWS
Department:Pharmacology
Source(s) of Funding:Small Project Funding
Start Date:06/2012


Project Title:EDHF 2012; Effect of isoflavones on the vascular actions of phosphodiesterase inhibitors
Investigator(s):Man RYK
Department:Pharmacology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2012


List of Research Outputs

Chan K.H., Chan C.H., Yeung S.C., Man R.Y.K., Ip M.S.M. and Mak J.C.W., Inhibitory effect of Chinese green tea on cigarette smoke-induced up-regulation of airway neutrophil elastase and matrix metalloproteinase-12 via antioxidant activity, Free Radical Research. 2012, Epub ahead of print.
Chan K.Y.C., Mak J.C.W., Gao Y.S., Man R.Y.K. and Vanhoutte P.M.G.R., Endothelium-derived NO, but not cyclic GMP, is required for hypoxic augmentation in isolated porcine coronary arteries, American Journal of Physiology - Heart and Circulatory Physiology. 2011, 301: H2313-H2321.
Keung W.Y.W. and Man R.Y.K., Circulating sex hormones modulate vascular contractions and acute response to 17b-estradiol in rat mesenteric arteries, Pharmacology. 2011, 88: 55-64.
Kwan Y.W., Leung S.W.S. and Man R.Y.K., 1,25-Dihydroxyvtamin D3 acutely reduces acetylcholine-induced endothelium-dependent contraction in hypertensive rat aorta through activation of protein kinase C, EDHF 2012 - 10TH Anniversary Meeting, Vaux-de-Cernay, France, June 27-30, 2012 . 2012, 30.
Kwan Y.W., Leung S.W.S. and Man R.Y.K., EPAC1 induces vasodilation on porcine coronary artery smooth muscle by Rho kinase I nhibition in a RAP1-independent pathway, Seventh International Symposium on Healthy Aging of the Research Centre of Heart, Brain, Hormone and Healthy Aging, March 3-4, 2012 Hong Kong. 2012, 50.
Kwan Y.W., Leung S.W.S. and Man R.Y.K., Epac-selective cyclic-AMP analog, 8-pCPT-2'-O-Me-cAMP, Induced Vasodilation in Porcine Coronary Artery by Rap1-independent Manner, 16th Research Postgraduate Symposium, December 7-8, 2011 Hong Kong. 2011, 2.10.
Kwan Y.W., Leung S.W.S. and Man R.Y.K., Epac1-selective cyclic-AMP analog 8-pCPT-2'-O-Me-cAMP induces vasodilation on porcine coronary artery in endothelium-independent pathway, BPS Winter Meeting London 2011, December 13-15. 2011, P041.
Kwong A.W.S., Leung S.W.S. and Man R.Y.K., Effect of isolavones on the vascular actions of phosphodiesterase inhibitors, EDHF 2012 - 10TH Anniversary Meeting, Vaux-de-Cernay, France, June 27-30, 2012 . 2012, 31.
Leung S.W.S., Chan M.L.Y., Man G.S.K. and Man R.Y.K., Ovariectomy promotes the enhancement of endothelium-derived hyperpolarizing factor-mediated relaxation in mesenteric arteries of rats with chronic nitric oxide synthase inhibition, Fifteenth Annual Scientific Meeting of The Institute of Cardiovascular Science and Medicine, September 17, 2011 Hong Kong, 2011, 15. 2011, 15.
Li Z., Tang E.H.C., Wang Y., Man R.Y.K. and Vanhoutte P.M.G.R., Up-regulation of Heme Oxygenase-1 by Hemin Improves Endothelial Function in the Spontaneously Hypertensive Rat, 16th Research Postgraduate Symposium, December 7-8, 2011 Hong Kong. 2011, 161; 1.09.
Liang C., Man R.Y.K. and Xu A., Loss of function in toll-like receptor 4 curtails endothelial dysfunction in genetically obese mice, Fourth Scientific Meeting of the Asian Society for Vascular Biology, Hong Kong 20-21 November, 2010. 2011, 29.
Manio M.M., Vanhoutte P.M.G.R., Man R.Y.K. and Ng J.K.F., In Vivo Administration of LPS Reduces Dexmedetomidine-Induced Contraction in Isolated Rat Aortae, 16th Research Postgraduate Symposium, December 7-8, 2011 Hong Kong. 2011, 153; 5.35.
Manio M.M., Man R.Y.K., Vanhoutte P.M.G.R. and Ng J.K.F., In vivo administration of LPS reduces dexmedetomidine-induced contraction in isolated rat aortae, Experimental Biology 2012, April 21-25, San Diego, CA. 2012, 259, 840.7.
Zhang Y., Leung S.W.S. and Man R.Y.K., Effects of luteolin on endothelium-dependent relaxation is different between male and female rat mesenteric arteries: relationship with endothelium-derived hyperpolarizing factor and cyclooxygenase pathways, Fifteenth Annual Scientific Meeting of The Institute of Cardiovascular Science and Medicine, September 17, 2011 Hong Kong, 2011, 7 . 2011.
Zhang Y., Leung S.W.S. and Man R.Y.K., Gender-specific Relaxation of Flavonoids in Rat Mesenteric Arteries, 15th Research Postgraduate Symposium, Hong Kong, December 1-2, 2010. 2011, 100.
Zhang Y., Leung S.W.S. and Man R.Y.K., Gender-specific effects of luteolin in the enhancement of endothelium-dependent relaxation in 45-50 weeks old rat mesenteric arteries: role of endothelium-derived hyperpolarizing factors and cyclooxygenase, Chinese Journal of Pharmacology and Toxicology, HKPS / CPS Jointly Meeting, September 23-25, 2011 Jinan China. 2011, 25: 139.
Zhang Y., Leung S.W.S. and Man R.Y.K., Gender-specific relaxation of flavonoids in rat's mesenteric arteries, Fourth Scientific Meeting of the Asian Society for Vascular Biology, Hong Kong 20-21 November, 2010. 2011, 33.


Researcher : Manio MM

List of Research Outputs

Manio M.M., Vanhoutte P.M.G.R., Man R.Y.K. and Ng J.K.F., In Vivo Administration of LPS Reduces Dexmedetomidine-Induced Contraction in Isolated Rat Aortae, 16th Research Postgraduate Symposium, December 7-8, 2011 Hong Kong. 2011, 153; 5.35.
Manio M.M., Man R.Y.K., Vanhoutte P.M.G.R. and Ng J.K.F., In vivo administration of LPS reduces dexmedetomidine-induced contraction in isolated rat aortae, Experimental Biology 2012, April 21-25, San Diego, CA. 2012, 259, 840.7.


Researcher : Ng JKF

Project Title:Effect of desmopressin on platelet dysfunction associated with mild hypothermia in healthy volunteers
Investigator(s):Ng JKF, Cheung CW
Department:Anaesthesiology
Source(s) of Funding:Small Project Funding
Start Date:12/2009
Completion Date:11/2011


Project Title:Vascular effects of dexmedetomidine
Investigator(s):Ng JKF, Leung GPH, Vanhoutte PMGR
Department:Anaesthesiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2010
Completion Date:12/2011


Project Title:HAA 2011 Perioperative sCD40L and PFA-100® Profiles During Major Noncardiac Surgery
Investigator(s):Ng JKF
Department:Anaesthesiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2011
Completion Date:11/2011


Project Title:The role of endothelial arginine, arginase and nitric oxide on dexmedetomidine induced vascular contraction
Investigator(s):Ng JKF, Leung SWS
Department:Anaesthesiology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012


List of Research Outputs

Wang T., Qiao S., Lei S., Liu Y., Ng J.K.F., Ng J.K.F., Xu A., Xu A., Lam K.S.L., Irwin M.G. and Xia Z., N-acetylcysteine and allopurinol synergistically enhance cardiac adiponectin content and reduce myocardial reperfusion injury in diabetic rats, PLoS One. 2011, 6(8): e23967.


Researcher : Sit SM

List of Research Outputs

Li R.W.S., Yang C., Sit S.M., Lin Y.T., Ho Y.W. and Leung G.P.H., Physiological and Pharmacological roles of Vascular Nucleoside Transporters, J Cardiovasc Pharmacol. 2012, 59: 10-15.
Li R.W.S., Yang C., Sit S.M., Lin Y.T., Ho Y.W. and Leung G.P.H., Physiological and Pharmacological roles of vascular nucleoside transporters., Journal of Cardiovascular Pharmacology . 2012, 59: 10-15.
Lin Y.T., Li R.W.S., Sit S.M., Kwan Y.W. and Leung G.P.H., Effects of emodin on nucleside transporters in endothelial cells, 16th Research Postgraduate Symposium, December 7-8, 2011 Hong Kong. 2011, 2.17.
Lin Y.T., Li R.W.S., Sit S.M., Kwan Y.W. and Leung G.P.H., Inhibition of nucleoside transporters in endothelial cells by emodin, Fifteenth Annual Scientific Meeting of The Institute of Cardiovascular Science and Medicine, September 17, 2011 Hong Kong. 2011, 9.


Researcher : Sit SM

List of Research Outputs

Li R.W.S., Yang C., Sit S.M., Lin Y.T., Ho Y.W. and Leung G.P.H., Physiological and Pharmacological roles of Vascular Nucleoside Transporters, J Cardiovasc Pharmacol. 2012, 59: 10-15.
Li R.W.S., Yang C., Sit S.M., Lin Y.T., Ho Y.W. and Leung G.P.H., Physiological and Pharmacological roles of vascular nucleoside transporters., Journal of Cardiovascular Pharmacology . 2012, 59: 10-15.
Lin Y.T., Li R.W.S., Sit S.M., Kwan Y.W. and Leung G.P.H., Effects of emodin on nucleside transporters in endothelial cells, 16th Research Postgraduate Symposium, December 7-8, 2011 Hong Kong. 2011, 2.17.
Lin Y.T., Li R.W.S., Sit S.M., Kwan Y.W. and Leung G.P.H., Inhibition of nucleoside transporters in endothelial cells by emodin, Fifteenth Annual Scientific Meeting of The Institute of Cardiovascular Science and Medicine, September 17, 2011 Hong Kong. 2011, 9.


Researcher : Song E

List of Research Outputs

Fan P., Song E., Xu A., Feletou M., Vilaine J.P., Vanhoutte P.M.G.R. and Huang Y., Elevated 20-Hete contributes to the improved endothelial function in lipocalin-2 deficient mice, EDHF 2012 - 10TH Anniversary Meeting, Vaux-de-Cernay, France, June 27-30, 2012 . 2012, 16.
Liu T.C., Song E., Xu A., Berger T., Mak T., Tse H.F., Law K.M., Huang B., Vanhoutte P.M.G.R. and Wang Y., Lipocalin-2 deficiency prevents endothelial dysfunction associated with dietary obesity: role of cytochrome P450 2C inhibition., British Journal of Pharmacology. 2011.
Song E., Fan P., Xu A., Vanhoutte P.M.G.R. and Wang Y., Lipocalin-2 mediates linoleic acid-induced endothelial dysfunction, Experimental Biology 2012, April 21-25, San Diego, CA. 2012, 259, 840.9.
Song E., Vanhoutte P.M.G.R., Xu A. and Wang Y., Mechanisms underlying endothelial dysfunction induced by dietary obesity: role of lipocalin-2, 16th Research Postgraduate Symposium, December 7-8, 2011 Hong Kong. 2011, 90, 2.22.
Wang Y., Huang B., Song E., Xu A., Feletou M. and Vilaine J.P., Obesity-accelerated arterial aging: interplay between free fatty acids and lipocalin-2, EDHF 2012 - 10th Anniversary Meeting, Vaux-de-Cernay, France, June 27-30, 2012. 49.
Yang B., Fan P., Xu A., Lam K.S.L., Berger T., Mak T., Tse H.F., Song E., Vanhoutte P.M.G.R. and Wang Y., Improved functional recovery to I/R injury in hearts from lipocalin-2 deficiency mice: Restoration of Mitochondrial Function and Phospholipids Remodeling., American Journal of Translational Research. 2012.
Yang B., Fan P., Xu A., Lam K.S.L., Berger T., Mak T.W., Tse H.F., Yue W., Song E., Vanhoutte P.M.G.R., Sweeney G. and Wang Y., Improved functional recovery to I/R injury in hearts from lipocalin-2 deficiency mice: restoration of mitochondrial function and phospholipids remodeling, Am J Transl Res. 2012, 4(1): 60-71.


Researcher : Song E

List of Research Outputs

Fan P., Song E., Xu A., Feletou M., Vilaine J.P., Vanhoutte P.M.G.R. and Huang Y., Elevated 20-Hete contributes to the improved endothelial function in lipocalin-2 deficient mice, EDHF 2012 - 10TH Anniversary Meeting, Vaux-de-Cernay, France, June 27-30, 2012 . 2012, 16.
Liu T.C., Song E., Xu A., Berger T., Mak T., Tse H.F., Law K.M., Huang B., Vanhoutte P.M.G.R. and Wang Y., Lipocalin-2 deficiency prevents endothelial dysfunction associated with dietary obesity: role of cytochrome P450 2C inhibition., British Journal of Pharmacology. 2011.
Song E., Fan P., Xu A., Vanhoutte P.M.G.R. and Wang Y., Lipocalin-2 mediates linoleic acid-induced endothelial dysfunction, Experimental Biology 2012, April 21-25, San Diego, CA. 2012, 259, 840.9.
Song E., Vanhoutte P.M.G.R., Xu A. and Wang Y., Mechanisms underlying endothelial dysfunction induced by dietary obesity: role of lipocalin-2, 16th Research Postgraduate Symposium, December 7-8, 2011 Hong Kong. 2011, 90, 2.22.
Wang Y., Huang B., Song E., Xu A., Feletou M. and Vilaine J.P., Obesity-accelerated arterial aging: interplay between free fatty acids and lipocalin-2, EDHF 2012 - 10th Anniversary Meeting, Vaux-de-Cernay, France, June 27-30, 2012. 49.
Yang B., Fan P., Xu A., Lam K.S.L., Berger T., Mak T., Tse H.F., Song E., Vanhoutte P.M.G.R. and Wang Y., Improved functional recovery to I/R injury in hearts from lipocalin-2 deficiency mice: Restoration of Mitochondrial Function and Phospholipids Remodeling., American Journal of Translational Research. 2012.
Yang B., Fan P., Xu A., Lam K.S.L., Berger T., Mak T.W., Tse H.F., Yue W., Song E., Vanhoutte P.M.G.R., Sweeney G. and Wang Y., Improved functional recovery to I/R injury in hearts from lipocalin-2 deficiency mice: restoration of mitochondrial function and phospholipids remodeling, Am J Transl Res. 2012, 4(1): 60-71.


Researcher : Tang EHC

Project Title:The role of EP4 in inflammation of adipose tissue
Investigator(s):Tang EHC, Vanhoutte PMGR
Department:Pharmacology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:08/2010
Completion Date:08/2012


Project Title:EP4 agonists alleviate inflammation in mouse models of atherosclerosis and obesity.
Investigator(s):Tang EHC, Vanhoutte PMGR
Department:Pharmacology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2012


Project Title:EDHF2012 PROSTAGLANDIN E2-EP4 SIGNALING REDUCES INFLAMMATION IN MOUSE ADIPOSE TISSUE
Investigator(s):Tang EHC
Department:Pharmacology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2012


List of Research Outputs

Cai Y., Vanhoutte P.M.G.R. and Tang E.H.C., Knockdown of Rap 1 Suppresses NF-kB-dependent inflammation in Human Macrophages, 17th Research Postgraduate Symposium, Hong Kong, December 12 & 13, 2012. 85.
Li Z., Tang E.H.C., Wang Y., Man R.Y.K. and Vanhoutte P.M.G.R., Up-regulation of Heme Oxygenase-1 by Hemin Improves Endothelial Function in the Spontaneously Hypertensive Rat, 16th Research Postgraduate Symposium, December 7-8, 2011 Hong Kong. 2011, 161; 1.09.
Tang E.H.C., Libby P., Vanhoutte P.M.G.R. and Xu A., Anti-inflammation therapy by activation of prostaglandin EP4 receptor in cardiovascular and other inflammatory diseases, J Cardiovasc Pharmacol. 2012, 59(2): 116-23.
Tang E.H.C., Prostaglandin E2 alleviates adipose tissue inflammation, Institute of Cardiovascular Science and Medicine (ICSM) Quarterly Research Seminar. 5 June 2012, Faculty of Medicine Building, The University of Hong Kong. 2012.
Tang E.H.C., Wong C.K., Xu A. and Vanhoutte P.M.G.R., Prostaglandin E2-EP4 signaling reduces inflammation in mouse adipose tissue. , Journal of Vascular Research . 2012, 49: 1-54.
Tang E.H.C., Wong C.K., Xu A. and Vanhoutte P.M.G.R., Prostaglandin E2-EP4 signaling reduces inflammation in mouse adipose tissue, EDHF 2012 - 10TH Anniversary Meeting, Vaux-de-Cernay, France, June 27-30, 2012 . 2012, 46.
Tang E.H.C., Prostaglandin EP4 receptor: A promising therapeutic target for cardiovascular and other inflammatory diseases, The 21st International Conference of the Korean Scoeity for Gerontology: Intervention of Aging and Age-related Diseases 8-9 July 2011 Busan Korea.. 2011.
Tang E.H.C., The anti-inflammatory role of EP4 receptor in cardiovascular diseases, Forth Scientific Meeting Asian Soceity for Vascular Biology 20-21 November 2011, HKU. 2011.
Tang E.H.C., What is bulimia? Free yourself from weight obsession, stop overeating and emotional bingeing, 14th April 2012, Public Lecture Series, Hong Kong Central Library, Causeway Bay. 2012.


Researcher : Tang HC

Project Title:The role of EP4 in inflammation of adipose tissue
Investigator(s):Tang EHC, Vanhoutte PMGR
Department:Pharmacology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:08/2010
Completion Date:08/2012


Project Title:EP4 agonists alleviate inflammation in mouse models of atherosclerosis and obesity.
Investigator(s):Tang EHC, Vanhoutte PMGR
Department:Pharmacology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2012


Project Title:EDHF2012 PROSTAGLANDIN E2-EP4 SIGNALING REDUCES INFLAMMATION IN MOUSE ADIPOSE TISSUE
Investigator(s):Tang EHC
Department:Pharmacology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2012


List of Research Outputs



Researcher : Tom WM

Project Title:VII World Conference on Clinical Pharmacology and Therapeutics 4th Congress of the European Association for Clinical Pharmacology and Therapeutics Antidotal Mechanisms of Hydroxyacetone and Dihydroxyacetone in the Treatment of Acute Acetonitrile Poisoning
Investigator(s):Tom WM
Department:Pharmacology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:07/2000




Researcher : Vanhoutte P.M.G.

Project Title:Annual Summer School in Danish Cardiovascular Research Academy Veins in health and disease
Investigator(s):Vanhoutte PMGR
Department:Pharmacology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2007


Project Title:Visiting Research Professors Scheme 2009-10
Investigator(s):Vanhoutte PMGR
Department:Pharmacology
Source(s) of Funding:Visiting Research Professors Scheme
Start Date:09/2009


Project Title:A Study of the Relative Significance of Nitric Oxide Synthase vs NADPH oxidase in Endothelial Senescence
Investigator(s):Vanhoutte PMGR, Wang Y
Department:Pharmacology
Source(s) of Funding:Small Project Funding
Start Date:10/2009


Project Title:Vascular protective functions of the anti-aging protein SIRT1 by targeting LKB1/AMPK pathway in endothelial cells: tipping the balance towards vascular homeostasis
Investigator(s):Vanhoutte PMGR, Wang Y
Department:Pharmacology
Source(s) of Funding:General Research Fund (GRF)
Start Date:09/2011


List of Research Outputs



Researcher : Vanhoutte PMGR

Project Title:Annual Summer School in Danish Cardiovascular Research Academy Veins in health and disease
Investigator(s):Vanhoutte PMGR
Department:Pharmacology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2007


Project Title:Visiting Research Professors Scheme 2009-10
Investigator(s):Vanhoutte PMGR
Department:Pharmacology
Source(s) of Funding:Visiting Research Professors Scheme
Start Date:09/2009


Project Title:A Study of the Relative Significance of Nitric Oxide Synthase vs NADPH oxidase in Endothelial Senescence
Investigator(s):Vanhoutte PMGR, Wang Y
Department:Pharmacology
Source(s) of Funding:Small Project Funding
Start Date:10/2009


Project Title:Vascular protective functions of the anti-aging protein SIRT1 by targeting LKB1/AMPK pathway in endothelial cells: tipping the balance towards vascular homeostasis
Investigator(s):Vanhoutte PMGR, Wang Y
Department:Pharmacology
Source(s) of Funding:General Research Fund (GRF)
Start Date:09/2011


List of Research Outputs

Bai B., Liang Y., Xu C., Xu A.M., Kee M., Vanhoutte P.M.G.R. and Wang Y., CDK5 mediates SIRT1 phosphorylation at serine 47 during endothelial senescence, 16th Research Postgraduate Symposium, December 7-8, 2011 Hong Kong. 2011, 2.01.
Bai B., Liang Y., Xu C., Lee M.Y.K., Xu A., Wu D., Vanhoutte P.M.G.R. and Wang Y., CDK5-Mediated Hyperphosphorylation of SIRT1 Contributes to the Development of Endothelial Senescence and Atherosclerosis, Circulation. 2012.
Bai B., Vanhoutte P.M.G.R. and Wang Y., CDK5-mediated phosphorylation of SIRT1 at serine 47 contributes to the development of endothelial senescence, XVI International Symposium on Atherosclerosis, Sydney, Australia, 25-29 March, 2012. 64.
Baretella O.M., Li F.Y.L., Chung S.K. and Vanhoutte P.M.G.R., Reduction of contractions to phenylephrine by L-NAME in the carotid artery of mice with endothelial overexpression of endothelin-1, Experimental Biology 2012, April 21 - 25, 2012, San Diego, CA . 2012.
Cai Y., Vanhoutte P.M.G.R. and Tang E.H.C., Knockdown of Rap 1 Suppresses NF-kB-dependent inflammation in Human Macrophages, 17th Research Postgraduate Symposium, Hong Kong, December 12 & 13, 2012. 85.
Cai Y., Liang Y., Lee M.Y.K., Vanhoutte P.M.G.R., Wang Y. and Wang Y., MMP-7 in the development of endothelial dysfunctions and atherosclerosis, EDHF 2012 - 10TH Anniversary Meeting, Vaux-de-Cernay, France, June 27-30, 2012 . 2012, 10.
Cai Y., Leung G.P.H. and Vanhoutte P.M.G.R., Thyroid hormone affects both endothelial and vascular smooth muscle cells in rat arteries, Experimental Biology 2012, April 21-25, San Diego, CA. 2012, 189.
Chan K.Y.C., Mak J.C.W., Gao Y.S., Man R.Y.K. and Vanhoutte P.M.G.R., Endothelium-derived NO, but not cyclic GMP, is required for hypoxic augmentation in isolated porcine coronary arteries, American Journal of Physiology - Heart and Circulatory Physiology. 2011, 301: H2313-H2321.
Chow H.M., Liu J., Sun R.W.Y., Vanhoutte P.M.G.R., Xu A., Chen J., Che C.M. and Wang Y., The gold (III) porphyrin complex, gold-2a, supresses WNT1 expression in breast cancer cells by enhancing the promoter association of YY1, American Journal of Translational Research. 2011, 3: 479-491.
Fan P., Song E., Xu A., Feletou M., Vilaine J.P., Vanhoutte P.M.G.R. and Huang Y., Elevated 20-Hete contributes to the improved endothelial function in lipocalin-2 deficient mice, EDHF 2012 - 10TH Anniversary Meeting, Vaux-de-Cernay, France, June 27-30, 2012 . 2012, 16.
Feletou M., Huang Y. and Vanhoutte P.M.G.R., Endothelium-mediated control of vascular tone: COX-1 and COX-2 products, British Journal of Pharmacology. 2011, 164: 894-912.
Feletou M., Kohler R. and Vanhoutte P.M.G.R., Nitric oxide: Orchestrator of endothelium-dependent responses, Annals of Medicine. 2011, 1-23.
Gao Y. and Vanhoutte P.M.G.R., Nebivolol: An Endothelium-Friendly Selective b1-Adrenoceptor Blocker, J Cardiovasc Pharmacol. 2012, 59: 16-21.
Hagensen M.K., Vanhoutte P.M.G.R. and Bentzon J.F., Arterial endothelial cells: still the craftsmen of regenerated endothelium, Cardiovascular Research. 2012, 95: 281-289.
Hui X., Lam K.S.L., Vanhoutte P.M.G.R. and Xu A., Adiponectin and cardiovascular health: an update., Br J Pharmacol. 2012, 165(3): 574-90.
Hui X., Lam K.S.L., Vanhoutte P.M.G.R. and Xu A., Adiponectin and cardiovascular health: an update, British Journal of Pharmacology. 2012, 165: 574-590.
Lee M.Y.K., Cai Y., Wang Y., Liao S., Liu Y., Zhang Y., Bai B., Tse H.F. and Vanhoutte P.M.G.R., Differential genomic changes caused by cholesterol - and PUFA-rich diets in regenerated porcine coronary endothelial cells, Physiolgical Genomics. 2012, 44: 551-561.
Leung J.W.C., Wong W.T., Koon H.W., Mo F.M., Tam S., Huang Y., Vanhoutte P.M.G.R., Chung S.S.M. and Chung S.K., Transgenic mice over-expressing ET-1 in the endothelial cells develop systemic hypertension with altered vascular reactivity, PLoS One. 2011, 6:11: 1-8.
Li Z., Wang Y. and Vanhoutte P.M.G.R., Heme oxygenase-1 induction by hemin enhances EDHF-mediated relaxations in the mesenteric artery of the SHR, Fifteen Annual Scientific Meeting of The Institute of Cardiovascular Science and Medicine, September 30, 2011 Hong Kong. 2011, 8.
Li Z., Tang E.H.C., Wang Y., Man R.Y.K. and Vanhoutte P.M.G.R., Up-regulation of Heme Oxygenase-1 by Hemin Improves Endothelial Function in the Spontaneously Hypertensive Rat, 16th Research Postgraduate Symposium, December 7-8, 2011 Hong Kong. 2011, 161; 1.09.
Li Z. and Vanhoutte P.M.G.R., Up-regulation of heme oxygenase-1 improves endothelial function in the spontaneous hypertensive rat, Chinese Journal of Pharmacology and Toxicology, HKPS / CPS Joint Meeting, September 22-25, 2011 Jinan China. 2011, 25: 138.
Li Z., Wang Y. and Vanhoutte P.M.G.R., Upregulation of heme oxygenase 1 by hemin impairs endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat, Hypertension. 2011, 58: 926-934.
Liang Y., Liu L., Xu A.M., Vanhoutte P.M.G.R. and Wang Y., The lysine 64 residue of the protein kinase LKB1 is critically involved in regulating endothelial senescence by SIRT1, 16th Research Postgraduate Symposium, December 7-8, 2011 Hong Kong. 2011, 2.16.
Liu T.C., Song E., Xu A., Berger T., Mak T., Tse H.F., Law K.M., Huang B., Vanhoutte P.M.G.R. and Wang Y., Lipocalin-2 deficiency prevents endothelial dysfunction associated with dietary obesity: role of cytochrome P450 2C inhibition., British Journal of Pharmacology. 2011.
Liu Y., Lei S., GAO X., Mao X., Wang T., Wong G.T.C., Vanhoutte P.M.G.R., Irwin M.G. and Xia Z., PKCb inhibition with ruboxistaurin reduces oxidative stress and attenuates left ventricular hypertrophy and dysfunction in rats with streptozotocin-induced diabetes, Clin Sci (Lond). 2012, 122(4): 161-173.
Manio M.M., Vanhoutte P.M.G.R., Man R.Y.K. and Ng J.K.F., In Vivo Administration of LPS Reduces Dexmedetomidine-Induced Contraction in Isolated Rat Aortae, 16th Research Postgraduate Symposium, December 7-8, 2011 Hong Kong. 2011, 153; 5.35.
Manio M.M., Man R.Y.K., Vanhoutte P.M.G.R. and Ng J.K.F., In vivo administration of LPS reduces dexmedetomidine-induced contraction in isolated rat aortae, Experimental Biology 2012, April 21-25, San Diego, CA. 2012, 259, 840.7.
Mao X., Liu Y., Wang T., Lei S., Irwin M.G., Vanhoutte P.M.G.R. and Xia Z., Antioxidants N-acetylcysterine and Allopurinol synergistically enhance cardiac HIF-1α and heme oxygenase-1 and attenuate Postischemic Myocardial Injury in Diabetic Rats, FASEB Journal. 2012, 26: 1114.3.
Nejad A., Lee S.S., Vanhoutte P.M.G.R. and Leung S.W.S., Antiretroviral treatment can affect the release of NO and EDCF, but EDH in rat arteries, EDHF 2012 - 10TH Anniversary Meeting, Vaux-de-Cernay, France, June 27-30, 2012 . 2012, 37.
Shi Y., Cosentino F., Camici G.G., Akhmedov A., Vanhoutte P.M.G.R., Tanner F.C. and Luscher T.F., Oxidized Low-Density Lipoprotein Activates p66Shevia Lectin-Like Oxidized Low-Density Lipoprotein Receptor-1, Protein Kinase C-b, and c-Jun N-Terminal Kinase Kinase in Human Endothelial Cells, Arteriosclerosis, Thrombosis, and Vascular Biology, Journal of The American Heart Associations. 2011, 31: 2090-2097.
Song E., Fan P., Xu A., Vanhoutte P.M.G.R. and Wang Y., Lipocalin-2 mediates linoleic acid-induced endothelial dysfunction, Experimental Biology 2012, April 21-25, San Diego, CA. 2012, 259, 840.9.
Song E., Vanhoutte P.M.G.R., Xu A. and Wang Y., Mechanisms underlying endothelial dysfunction induced by dietary obesity: role of lipocalin-2, 16th Research Postgraduate Symposium, December 7-8, 2011 Hong Kong. 2011, 90, 2.22.
Staehr M., Madsen K., Vanhoutte P.M.G.R., Hansen P...B... and Jensen B...L..., Disruption of COX-2 and eNOS does not confer protection from cardiovascular failure in lipopolysaccharide-treated conscious mice and isolated vascular rings, American Journal of Physiology Regulatory, Intergrative and Comparative Physiology. 2011, 301: R412-R420.
Tang E.H.C., Libby P., Vanhoutte P.M.G.R. and Xu A., Anti-inflammation therapy by activation of prostaglandin EP4 receptor in cardiovascular and other inflammatory diseases, J Cardiovasc Pharmacol. 2012, 59(2): 116-23.
Tang E.H.C., Wong C.K., Xu A. and Vanhoutte P.M.G.R., Prostaglandin E2-EP4 signaling reduces inflammation in mouse adipose tissue. , Journal of Vascular Research . 2012, 49: 1-54.
Tang E.H.C., Wong C.K., Xu A. and Vanhoutte P.M.G.R., Prostaglandin E2-EP4 signaling reduces inflammation in mouse adipose tissue, EDHF 2012 - 10TH Anniversary Meeting, Vaux-de-Cernay, France, June 27-30, 2012 . 2012, 46.
Tian X.Y., Wong W.T., Leung F.P., Zhang Y., Wang Y.X., Lee H.K., Ng C.F., Chen Z.Y., Yao X.Q., Au C.L., Lau C.W., Vanhoutte P.M.G.R., Cooke J.P. and Huang Y., Oxidative stress-dependent cyclooxygenase-2-derived prostaglandin F2a impairs endothelial function in renovascular hypertensive rats, Antioxidants & Redox Signaling. 2011, 16: 363-373.
Vanhoutte P.M.G.R., Obesity and vascular dysfunction: the fat-e of rich and poor, British Journal of Pharmacology. 2011, 165: 541-543.
Wang P., Vanhoutte P.M.G.R. and Miao C., Visfatin and Cardio-Cerebro-Vascular Disease, J Cardiovasc Pharmacol. 2012, 59: 1-9.
Wang Y., Cheng K.Y., Lam K.S.L., Wu D., Wang Y., Huang Y., Vanhoutte P.M.G.R., Sweeney G., Li Y. and Xu A., APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice, Diabetes. 2011, 60: 3044-3054.
Wang Y., Cheng K.Y., Lam K.S.L., Wu D., Wang Y., Huang Y., Vanhoutte P.M.G.R., Sweeney G., Li Y. and Xu A., APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice, Diabetes . 2011, 60(11): 3044-54.
Wong T.W., Tian X.Y., Xu A., Yu J., Lau C.W., Hoo R.L.C., Wang Y., Lee V.W.Y., Lam K.S.L., Vanhoutte P.M.G.R. and Huang Y., Adiponectin is required for PPARgmediated improvement of endothelial function in diabetic mice, Cell Metabolism. 2011, 14: 104-115.
Wong W.T., Tian X.Y., Xu A., Yu J., Lau C.W., Hoo R.L.C., Wang Y., Lee VW , Lam K.S.L., Vanhoutte P.M.G.R. and Huang Y., Adiponectin is required for PPARγ-mediated improvement of endothelial function in diabetic mice, Cell Metabolism. 2011, 14: 104-115.
Xu A. and Vanhoutte P.M.G.R., Adiponectin and adipocyte fatty acid binding protein in the pathogensis of cardiovascular disease, American Journal of Physiology - Heart and Circulatory Physiology. 2012, 302: H1231-H1240.
Xu C., Xu A., Vanhoutte P.M.G.R. and Wang Y., Anti-aging effects of SIRT1 in adipose tissue, 16th Research Postgraduate Symposium, December 7-8, 2011 Hong Kong. 2011, 1.21.
Xu C., Vanhoutte P.M.G.R. and Wang Y., SIRT1 enhances endothelium-dependent relaxation through an eNOS-independent mechanism, Experimental Biology 2012, April 21-25, San Diego, CA. 2012, 189, B116.
Yang B., Fan P., Xu A., Lam K.S.L., Berger T., Mak T., Tse H.F., Song E., Vanhoutte P.M.G.R. and Wang Y., Improved functional recovery to I/R injury in hearts from lipocalin-2 deficiency mice: Restoration of Mitochondrial Function and Phospholipids Remodeling., American Journal of Translational Research. 2012.
Yang B., Fan P., Xu A., Lam K.S.L., Berger T., Mak T.W., Tse H.F., Yue W., Song E., Vanhoutte P.M.G.R., Sweeney G. and Wang Y., Improved functional recovery to I/R injury in hearts from lipocalin-2 deficiency mice: restoration of mitochondrial function and phospholipids remodeling, Am J Transl Res. 2012, 4(1): 60-71.
Yang B., Vanhoutte P.M.G.R. and Wang Y., Lipocalin-2 mediated myocardial extracellular matrix remodeling is correlated with Akt/P38 activity in hearts, Experimental Biology 2012, April 21-25, San Diego, CA. 2012, 380, S4.
Zhao Y., Leung S.W.S. and Vanhoutte P.M.G.R., Activation of A1-adrenergic receptors causes thromoxane-prostanoid receptor desensitization in the aorta of the spontaneously hypertensive rat, Fifteenth Annual Scientific Meeting of The Institute of Cardiovascular Science and Medicine, September 17, 2011 Hong Kong. 2011, 12.
Zhao Y., Chan K.Y.C., Liao S., Tse H.F., Leung S.W.S., Xu A. and Vanhoutte P.M.G.R., Apocynin and BMS309403 reduce dysfunction of regenerated endothelium of the pig coronary artery, Seventh International Symposium on Healthy Aging of the Research Centre of Heart, Brain, Hormone and Healthy Aging, March 3-4, 2012, Hong Kong. 2012, 70.
Zhao Y., Leung S.W.S. and Vanhoutte P.M.G.R., Endothelial NOS-Independent Release of Nitric Oxide in the Aorta of the Spontaneously Hypertensive Rat , 16th Research Postgraduate Symposium, December 7-8, 2011 Hong Kong. 2011, 95, 2.32.
Zhao Y., Leung S.W.S. and Vanhoutte P.M.G.R., Endothelial NOS-independent release of nitric oxide in the aorta of the spontaneously hypertensive rat, Chinese Journal of Pharmacology and Toxicology, HKPS / CPS Jointly Meeting, September 23-25, 2011, Jinan China. 2011, 25: 140.
Zhao Y., Leung S.W.S. and Vanhoutte P.M.G.R., Endothelial NOS-independent release of nitric oxide in the aorta of the spontaneously hypertensive rat, Experimental Biology 2012, April 21-25, San Diego, CA. 2012, 259, 840.1.
Zou Q. and Vanhoutte P.M.G.R., Activation of Nicotinic Receptors Contributes to Acetylcholine Induced Endothelium-dependent Relaxations in the Aorta of the Spontaneous Hypertensive Rat, 15th Research Postgraduate Symposium, Hong Kong, December 1-2, 2011. 102.
Zou Q. and Vanhoutte P.M.G.R., Activation of n-AChRs contributes to endothelium-dependent relaxations in the rat aorta, Chinese Journal of Pharmacology and Toxicology, HKPS / CPS Jointly Meeting, September 23-25, 2011 Jinan China. 2011, 25: 140.
Zou Q., Leung S.W.S. and Vanhoutte P.M.G.R., Activation of nicotinic receptors can contribute to endothelium-dependent relaxations to acetylcholine in the rat aorta, The Journal of Pharmacology and Expermental Therapeutics. 2012, 341: 756-763.


Researcher : Wang Y

Project Title:Molecular mechanisms underlying the hepato-protective functions of the fat cell-derived hormone adiponectin: potential roles of uncoupling protein 2
Investigator(s):Wang Y, Xu A
Department:Biochemistry
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2009
Completion Date:06/2012


Project Title:Protective effect of lipocalin-2 deficiency on aging- and dietary obesity-induced endothelial dysfunction
Investigator(s):Wang Y, Vanhoutte PMGR
Department:Pharmacology
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2010


Project Title:Outstanding Young Researcher Award 2009-10
Investigator(s):Wang Y
Department:Pharmacology
Source(s) of Funding:Outstanding Young Researcher Award
Start Date:12/2010


Project Title:YY1 as a negative regulator of WNT1 gene expression: a role in mammary carcinogenesis
Investigator(s):Wang Y, Xu A
Department:Pharmacology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2011
Completion Date:05/2012


Project Title:Oxidative peptide signatures as potential diagnostic biomarkers for obesity-related diabetes and cardiovascular diseases
Investigator(s):Wang Y, Siu AFM
Department:Pharmacology
Source(s) of Funding:Seed Funding Programme for Applied Research
Start Date:03/2012


Project Title:SIRT1 in cardiometabolic syndrome: Does liver play a role?
Investigator(s):Wang Y, Vanhoutte PMGR
Department:Pharmacology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012


Project Title:The Tenth Anniversary EDHF Meeting - EDHF2012 Obesity-accelerated arterial aging: interplay between free fatty acids and lipocalin-2
Investigator(s):Wang Y
Department:Pharmacology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2012


List of Research Outputs

Bai B., Liang Y., Xu C., Xu A.M., Kee M., Vanhoutte P.M.G.R. and Wang Y., CDK5 mediates SIRT1 phosphorylation at serine 47 during endothelial senescence, 16th Research Postgraduate Symposium, December 7-8, 2011 Hong Kong. 2011, 2.01.
Bai B., Liang Y., Xu C., Lee M.Y.K., Xu A., Wu D., Vanhoutte P.M.G.R. and Wang Y., CDK5-Mediated Hyperphosphorylation of SIRT1 Contributes to the Development of Endothelial Senescence and Atherosclerosis, Circulation. 2012.
Bai B., Vanhoutte P.M.G.R. and Wang Y., CDK5-mediated phosphorylation of SIRT1 at serine 47 contributes to the development of endothelial senescence, XVI International Symposium on Atherosclerosis, Sydney, Australia, 25-29 March, 2012. 64.
Cai Y., Liang Y., Lee M.Y.K., Vanhoutte P.M.G.R., Wang Y. and Wang Y., MMP-7 in the development of endothelial dysfunctions and atherosclerosis, EDHF 2012 - 10TH Anniversary Meeting, Vaux-de-Cernay, France, June 27-30, 2012 . 2012, 10.
Cheng K.Y., Lam K.S.L., Wu D.C.G., Wang Y., Sweeney G., Hoo R.L.C., Zhang J. and Xu A., APPL1 Promotes Insulin Secretion by Modulating Expression and Complex Formation of SNARE Proteins in Mice, Proc Natl Acad Sci USA. 2012, 109(23): 8919-24.
Cheng K.Y., Lam K.S.L., Wu D., Wang Y., Sweeney G., Hoo R.L.C., Zhang J. and Xu A., APPL1 potentiates insulin secretion in pancreatic β cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in mice., Proc Natl Acad Sci U S A. . United State, 2012, 109: 8919.
Cheung B.M.Y., Woo Y.C., Tso A.W.K., Ong K.L., Fong H.Y., Wang Y., Xu A. and Lam K.S.L., Plasma lipocalin-2 concentration is related to blood pressure and is increased in hypertension, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 18.
Chow H.M., Liu J., Sun R.W.Y., Vanhoutte P.M.G.R., Xu A., Chen J., Che C.M. and Wang Y., The gold (III) porphyrin complex, gold-2a, supresses WNT1 expression in breast cancer cells by enhancing the promoter association of YY1, American Journal of Translational Research. 2011, 3: 479-491.
Fan P. and Wang Y., Adipokines-Toward the Molecular Dissection of Interactions between Stromal Adipocytes and Breast Cancer Cells, Breast Cancer Cells/Book 5. InTech press, 2011.
Ge X., Chen C., Hui X., Wang Y., Lam K.S.L. and Xu A., Fibroblast growth factor 21 induces glucose transporter-1 expression through activation of the serum response factor/ Ets-like protein-1 in adipocytes, J Biol Chem. 2011.
Herath M.T.D.K.H., Wang Y., Seneviratne C.J., Darveau R...P..., Wang C...Y... and Jin L., 2011 International Association for Dental Research (IADR) - South East Asia Division /Unilever Hatton Divisional Award (Senior category), Singapore (Primary Supervisor for Ms. H.M.T.D.K. Herath, a PhD student), IADR - South East Asia Division. 2011.
Herath M.T.D.K.H., Wang Y., Seneviratne C.J., Darveau R.P., Wang C.Y. and Jin L., Novel pathogenic mechanisms of heterogeneous PG-LPS structures in periodontal disease, Journal of Dental Research. 2011, 90 (Spec Iss B): SD008 (SEA Division).
Herath M.T.D.K.H., Wang Y., Seneviratne C.J., Darveau R.P., Wang C. and Jin L., Novel pathogenic mechanisms of heterogeneous Pg-LPS structures in periodontal disease, Journal of Dental Research. 2012, 91 (Spec Iss B): 2643.
Herath M.T.D.K.H., Wang Y., Seneviratne C.J., Lu Q., Darveau R.P., Wang C.Y. and Jin L., Porphyromonas gingivalis lipopolysaccharide lipid A heterogeneity differentially modulates the expression of IL-6 and IL-8 in human gingival fibroblasts, Journal of Clinical Periodontology. 2011, 38: 694-701.
Lee M.Y.K., Cai Y., Wang Y., Liao S., Liu Y., Zhang Y., Bai B., Tse H.F. and Vanhoutte P.M.G.R., Differential genomic changes caused by cholesterol - and PUFA-rich diets in regenerated porcine coronary endothelial cells, Physiolgical Genomics. 2012, 44: 551-561.
Leung T.Y., Wang Y., Mak S.T., Ng W.C. and Leung K.M.Y., Differential proteomic responses in hepatopancreas and adductor muscles of the green-lipped mussel Perna viridis to stresses induced by cadmium and hydrogen peroxide, Aquatic Toxicology. 2011, 105: 49-61.
Leung T.Y., Park T.J., Wang Y. and Leung K.M.Y., Isoform-specific responses of metallothioneins in the green lipped mussel Perna viridis after exposure to cadmium and hydrogen peroxide, an oral presentation at the 15th International Symposium on Toxicity Assessment, held during 3-8 July 2011 at City University of Hong Kong, Hong Kong. 2011.
Li H., Hui X., Wang Y. and Xu A., High level expression, purification and characterization of active fusion human C1q and tumor necrosis factor related protein 2 (hCTRP2) in Escherichia coli , Protein Expression and Purification. 2011.
Li Z., Wang Y. and Vanhoutte P.M.G.R., Heme oxygenase-1 induction by hemin enhances EDHF-mediated relaxations in the mesenteric artery of the SHR, Fifteen Annual Scientific Meeting of The Institute of Cardiovascular Science and Medicine, September 30, 2011 Hong Kong. 2011, 8.
Li Z., Tang E.H.C., Wang Y., Man R.Y.K. and Vanhoutte P.M.G.R., Up-regulation of Heme Oxygenase-1 by Hemin Improves Endothelial Function in the Spontaneously Hypertensive Rat, 16th Research Postgraduate Symposium, December 7-8, 2011 Hong Kong. 2011, 161; 1.09.
Li Z., Wang Y. and Vanhoutte P.M.G.R., Upregulation of heme oxygenase 1 by hemin impairs endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat, Hypertension. 2011, 58: 926-934.
Liang Y., Xu A. and Wang Y., Selective activation of AMPK in eddothelial cells intensifies high fat diet-induced non-alcoholic fatty liver disease, Journal of Hepatology of The International Liver Congress 2012, Barcelona Spain, April 18-22, 2012. 56: S493.
Liang Y., Liu L., Xu A.M., Vanhoutte P.M.G.R. and Wang Y., The lysine 64 residue of the protein kinase LKB1 is critically involved in regulating endothelial senescence by SIRT1, 16th Research Postgraduate Symposium, December 7-8, 2011 Hong Kong. 2011, 2.16.
Liu J., Xu A., Lam K.S.L., Wong N.S., Chen J., Shepherd P.R. and Wang Y., Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation, 18th Hong Kong International Cancer Congress. 2011.
Liu J., Xu A., Lam K.S.L., Wong N.S., Chen J., Sheperd P.R. and Wang Y., Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation, The 18th Hong Kong International Cancer Conference. 2011.
Liu J., Xu A., Lam K.S.L., Wong N.S., Chen J., Shepherd P.R. and Wang Y., Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation, The 18th Hong Kong International Cancer Conference. 2011.
Liu L., Siu A.F.M., Che C.M., Xu A. and Wang Y., Akt blocks the tumor suppressor activity of LKB1 by promoting phosphorylation-dependent nuclear retention through 14-3-3 proteins, American Journal of Translational Research. 2012, 4: 175-186.
Liu T.C., Song E., Xu A., Berger T., Mak T., Tse H.F., Law K.M., Huang B., Vanhoutte P.M.G.R. and Wang Y., Lipocalin-2 deficiency prevents endothelial dysfunction associated with dietary obesity: role of cytochrome P450 2C inhibition., British Journal of Pharmacology. 2011.
Radjainia H., Huang B., Bai B., Schmitz M., Wang Y. and Mitra A., A highly conserved tryptophan in the N-terminal variable domain regulates rate of disulfide bond formation and oligomeric assembly of adiponectin., FEBS Journal. 2012.
Seneviratne C.J., Wang Y., Jin L. and Samaranayake L.P., Research Output Prize, The University of Hong Kong. 2012.
Seneviratne C.J., Wang Y., Jin L., Wong S.S.W., Herath M.T.D.K.H. and Samaranayake L.P., Unraveling the resistance of microbial biofilms: Has proteomics been helpful?, Proteomics. 2012, 12: 651-665.
Song E., Fan P., Xu A., Vanhoutte P.M.G.R. and Wang Y., Lipocalin-2 mediates linoleic acid-induced endothelial dysfunction, Experimental Biology 2012, April 21-25, San Diego, CA. 2012, 259, 840.9.
Song E., Vanhoutte P.M.G.R., Xu A. and Wang Y., Mechanisms underlying endothelial dysfunction induced by dietary obesity: role of lipocalin-2, 16th Research Postgraduate Symposium, December 7-8, 2011 Hong Kong. 2011, 90, 2.22.
Tian X.Y., Wong W.T., Xu A., Lu Y., Zhang Y., Wang L., Cheang W.S., Wang Y., Yao X. and Huang Y., Uncoupling protein-2 protects endothelial function in diet-induced obese mice, Circ Res. 2012, 110(9): 1211-6.
Wang Y., Cheng K.Y., Lam K.S.L., Wu D., Wang Y., Huang Y., Vanhoutte P.M.G.R., Sweeney G., Li Y. and Xu A., APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice, Diabetes. 2011, 60: 3044-3054.
Wang Y., Cheng K.Y., Lam K.S.L., Wu D., Wang Y., Huang Y., Vanhoutte P.M.G.R., Sweeney G., Li Y. and Xu A., APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice, Diabetes . 2011, 60(11): 3044-54.
Wang Y., Adipokines – toward the molecular dissection of interactions between stromal adipocytes and breast cancer cells, 18th Hong Kong International Cancer Congress. Hong Kong, 2011.
Wang Y., Lam K.S.L. and Xu A., Adiponectin and Chronic Liver Diseases: an Update, Adiponectin: Production, Regulation and Roles in Disease. NOVA SCIENCE PUBLISHERS, INC., 2011.
Wang Y., ISRN Nutrition, 2012.
Wang Y., Huang B., Song E., Xu A., Feletou M. and Vilaine J.P., Obesity-accelerated arterial aging: interplay between free fatty acids and lipocalin-2, EDHF 2012 - 10th Anniversary Meeting, Vaux-de-Cernay, France, June 27-30, 2012. 49.
Wang Y., Physiology Journal, 2012.
Wang Y., Zeng F., Long C.L., Pan Z.Y., Cui W.Y., Wang R.H. and Liu G.S., The novel ATP-sensitive potassium channel opener iptakalim prevents insulin resistance associated with hypertension via restoring endothelial function, Acta Pharmacologica Sinica. 2011, 32: 1466-1474.
Wong T.W., Tian X.Y., Xu A., Yu J., Lau C.W., Hoo R.L.C., Wang Y., Lee V.W.Y., Lam K.S.L., Vanhoutte P.M.G.R. and Huang Y., Adiponectin is required for PPARgmediated improvement of endothelial function in diabetic mice, Cell Metabolism. 2011, 14: 104-115.
Wong W.T., Tian X.Y., Xu A., Yu J., Lau C.W., Hoo R.L.C., Wang Y., Lee VW , Lam K.S.L., Vanhoutte P.M.G.R. and Huang Y., Adiponectin is required for PPARγ-mediated improvement of endothelial function in diabetic mice, Cell Metabolism. 2011, 14: 104-115.
Xu C., Xu A., Vanhoutte P.M.G.R. and Wang Y., Anti-aging effects of SIRT1 in adipose tissue, 16th Research Postgraduate Symposium, December 7-8, 2011 Hong Kong. 2011, 1.21.
Xu C., Vanhoutte P.M.G.R. and Wang Y., SIRT1 enhances endothelium-dependent relaxation through an eNOS-independent mechanism, Experimental Biology 2012, April 21-25, San Diego, CA. 2012, 189, B116.
Xu G., Ahn J., Chang S., Eguchi M., Ogier A., Han S., Park Y., Shim C., Jang Y., Yang B., Xu A., Wang Y. and Sweeney G., Lipocalin-2 induces cardiomyocyte apoptosis by increasing intracellular iron accumulation, J Biol Chem. 2012, 287(7): 4808-17.
Yang B., Fan P., Xu A., Lam K.S.L., Berger T., Mak T., Tse H.F., Song E., Vanhoutte P.M.G.R. and Wang Y., Improved functional recovery to I/R injury in hearts from lipocalin-2 deficiency mice: Restoration of Mitochondrial Function and Phospholipids Remodeling., American Journal of Translational Research. 2012.
Yang B., Fan P., Xu A., Lam K.S.L., Berger T., Mak T.W., Tse H.F., Yue W., Song E., Vanhoutte P.M.G.R., Sweeney G. and Wang Y., Improved functional recovery to I/R injury in hearts from lipocalin-2 deficiency mice: restoration of mitochondrial function and phospholipids remodeling, Am J Transl Res. 2012, 4(1): 60-71.
Yang B., Vanhoutte P.M.G.R. and Wang Y., Lipocalin-2 mediated myocardial extracellular matrix remodeling is correlated with Akt/P38 activity in hearts, Experimental Biology 2012, April 21-25, San Diego, CA. 2012, 380, S4.
Ye D., Li F.Y.L., Lam K.S.L., Li H., Jia W., Wang Y., Man K., Lo C.M., Li X. and Xu A., Toll-like receptor-4 mediates obesity-induced non-alcoholic steatohepatitis through activation of X-box binding protein-1 in mice, Gut. 2012.
Zhou M., Xu A., Tam P.K.H., Lam K.S.L., Huang B., Liang Y., Lee I.K., Wu D.H. and Wang Y., Upregulation of UCP2 by adiponectin: the involvement of mitochondrial superoxide and hnRNP K, PLoS One. 2012, 7(2): e32349.


Researcher : Wang Y

List of Research Outputs

Bai B., Liang Y., Xu C., Xu A.M., Kee M., Vanhoutte P.M.G.R. and Wang Y., CDK5 mediates SIRT1 phosphorylation at serine 47 during endothelial senescence, 16th Research Postgraduate Symposium, December 7-8, 2011 Hong Kong. 2011, 2.01.
Bai B., Liang Y., Xu C., Lee M.Y.K., Xu A., Wu D., Vanhoutte P.M.G.R. and Wang Y., CDK5-Mediated Hyperphosphorylation of SIRT1 Contributes to the Development of Endothelial Senescence and Atherosclerosis, Circulation. 2012.
Bai B., Vanhoutte P.M.G.R. and Wang Y., CDK5-mediated phosphorylation of SIRT1 at serine 47 contributes to the development of endothelial senescence, XVI International Symposium on Atherosclerosis, Sydney, Australia, 25-29 March, 2012. 64.
Cai Y., Liang Y., Lee M.Y.K., Vanhoutte P.M.G.R., Wang Y. and Wang Y., MMP-7 in the development of endothelial dysfunctions and atherosclerosis, EDHF 2012 - 10TH Anniversary Meeting, Vaux-de-Cernay, France, June 27-30, 2012 . 2012, 10.
Cheng K.Y., Lam K.S.L., Wu D.C.G., Wang Y., Sweeney G., Hoo R.L.C., Zhang J. and Xu A., APPL1 Promotes Insulin Secretion by Modulating Expression and Complex Formation of SNARE Proteins in Mice, Proc Natl Acad Sci USA. 2012, 109(23): 8919-24.
Cheng K.Y., Lam K.S.L., Wu D., Wang Y., Sweeney G., Hoo R.L.C., Zhang J. and Xu A., APPL1 potentiates insulin secretion in pancreatic β cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in mice., Proc Natl Acad Sci U S A. . United State, 2012, 109: 8919.
Cheung B.M.Y., Woo Y.C., Tso A.W.K., Ong K.L., Fong H.Y., Wang Y., Xu A. and Lam K.S.L., Plasma lipocalin-2 concentration is related to blood pressure and is increased in hypertension, Hong Kong Medical Journal. Presented at the Seventeenth Medical Research Conference, Hong Kong 2012. 18 (S1): 18.
Chow H.M., Liu J., Sun R.W.Y., Vanhoutte P.M.G.R., Xu A., Chen J., Che C.M. and Wang Y., The gold (III) porphyrin complex, gold-2a, supresses WNT1 expression in breast cancer cells by enhancing the promoter association of YY1, American Journal of Translational Research. 2011, 3: 479-491.
Fan P. and Wang Y., Adipokines-Toward the Molecular Dissection of Interactions between Stromal Adipocytes and Breast Cancer Cells, Breast Cancer Cells/Book 5. InTech press, 2011.
Ge X., Chen C., Hui X., Wang Y., Lam K.S.L. and Xu A., Fibroblast growth factor 21 induces glucose transporter-1 expression through activation of the serum response factor/ Ets-like protein-1 in adipocytes, J Biol Chem. 2011.
Herath M.T.D.K.H., Wang Y., Seneviratne C.J., Darveau R...P..., Wang C...Y... and Jin L., 2011 International Association for Dental Research (IADR) - South East Asia Division /Unilever Hatton Divisional Award (Senior category), Singapore (Primary Supervisor for Ms. H.M.T.D.K. Herath, a PhD student), IADR - South East Asia Division. 2011.
Herath M.T.D.K.H., Wang Y., Seneviratne C.J., Darveau R.P., Wang C.Y. and Jin L., Novel pathogenic mechanisms of heterogeneous PG-LPS structures in periodontal disease, Journal of Dental Research. 2011, 90 (Spec Iss B): SD008 (SEA Division).
Herath M.T.D.K.H., Wang Y., Seneviratne C.J., Darveau R.P., Wang C. and Jin L., Novel pathogenic mechanisms of heterogeneous Pg-LPS structures in periodontal disease, Journal of Dental Research. 2012, 91 (Spec Iss B): 2643.
Herath M.T.D.K.H., Wang Y., Seneviratne C.J., Lu Q., Darveau R.P., Wang C.Y. and Jin L., Porphyromonas gingivalis lipopolysaccharide lipid A heterogeneity differentially modulates the expression of IL-6 and IL-8 in human gingival fibroblasts, Journal of Clinical Periodontology. 2011, 38: 694-701.
Lee M.Y.K., Cai Y., Wang Y., Liao S., Liu Y., Zhang Y., Bai B., Tse H.F. and Vanhoutte P.M.G.R., Differential genomic changes caused by cholesterol - and PUFA-rich diets in regenerated porcine coronary endothelial cells, Physiolgical Genomics. 2012, 44: 551-561.
Leung T.Y., Wang Y., Mak S.T., Ng W.C. and Leung K.M.Y., Differential proteomic responses in hepatopancreas and adductor muscles of the green-lipped mussel Perna viridis to stresses induced by cadmium and hydrogen peroxide, Aquatic Toxicology. 2011, 105: 49-61.
Leung T.Y., Park T.J., Wang Y. and Leung K.M.Y., Isoform-specific responses of metallothioneins in the green lipped mussel Perna viridis after exposure to cadmium and hydrogen peroxide, an oral presentation at the 15th International Symposium on Toxicity Assessment, held during 3-8 July 2011 at City University of Hong Kong, Hong Kong. 2011.
Li H., Hui X., Wang Y. and Xu A., High level expression, purification and characterization of active fusion human C1q and tumor necrosis factor related protein 2 (hCTRP2) in Escherichia coli , Protein Expression and Purification. 2011.
Li Z., Wang Y. and Vanhoutte P.M.G.R., Heme oxygenase-1 induction by hemin enhances EDHF-mediated relaxations in the mesenteric artery of the SHR, Fifteen Annual Scientific Meeting of The Institute of Cardiovascular Science and Medicine, September 30, 2011 Hong Kong. 2011, 8.
Li Z., Tang E.H.C., Wang Y., Man R.Y.K. and Vanhoutte P.M.G.R., Up-regulation of Heme Oxygenase-1 by Hemin Improves Endothelial Function in the Spontaneously Hypertensive Rat, 16th Research Postgraduate Symposium, December 7-8, 2011 Hong Kong. 2011, 161; 1.09.
Li Z., Wang Y. and Vanhoutte P.M.G.R., Upregulation of heme oxygenase 1 by hemin impairs endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat, Hypertension. 2011, 58: 926-934.
Liang Y., Xu A. and Wang Y., Selective activation of AMPK in eddothelial cells intensifies high fat diet-induced non-alcoholic fatty liver disease, Journal of Hepatology of The International Liver Congress 2012, Barcelona Spain, April 18-22, 2012. 56: S493.
Liang Y., Liu L., Xu A.M., Vanhoutte P.M.G.R. and Wang Y., The lysine 64 residue of the protein kinase LKB1 is critically involved in regulating endothelial senescence by SIRT1, 16th Research Postgraduate Symposium, December 7-8, 2011 Hong Kong. 2011, 2.16.
Liu J., Xu A., Lam K.S.L., Wong N.S., Chen J., Shepherd P.R. and Wang Y., Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation, 18th Hong Kong International Cancer Congress. 2011.
Liu J., Xu A., Lam K.S.L., Wong N.S., Chen J., Sheperd P.R. and Wang Y., Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation, The 18th Hong Kong International Cancer Conference. 2011.
Liu J., Xu A., Lam K.S.L., Wong N.S., Chen J., Shepherd P.R. and Wang Y., Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation, The 18th Hong Kong International Cancer Conference. 2011.
Liu L., Siu A.F.M., Che C.M., Xu A. and Wang Y., Akt blocks the tumor suppressor activity of LKB1 by promoting phosphorylation-dependent nuclear retention through 14-3-3 proteins, American Journal of Translational Research. 2012, 4: 175-186.
Liu T.C., Song E., Xu A., Berger T., Mak T., Tse H.F., Law K.M., Huang B., Vanhoutte P.M.G.R. and Wang Y., Lipocalin-2 deficiency prevents endothelial dysfunction associated with dietary obesity: role of cytochrome P450 2C inhibition., British Journal of Pharmacology. 2011.
Radjainia H., Huang B., Bai B., Schmitz M., Wang Y. and Mitra A., A highly conserved tryptophan in the N-terminal variable domain regulates rate of disulfide bond formation and oligomeric assembly of adiponectin., FEBS Journal. 2012.
Seneviratne C.J., Wang Y., Jin L. and Samaranayake L.P., Research Output Prize, The University of Hong Kong. 2012.
Seneviratne C.J., Wang Y., Jin L., Wong S.S.W., Herath M.T.D.K.H. and Samaranayake L.P., Unraveling the resistance of microbial biofilms: Has proteomics been helpful?, Proteomics. 2012, 12: 651-665.
Song E., Fan P., Xu A., Vanhoutte P.M.G.R. and Wang Y., Lipocalin-2 mediates linoleic acid-induced endothelial dysfunction, Experimental Biology 2012, April 21-25, San Diego, CA. 2012, 259, 840.9.
Song E., Vanhoutte P.M.G.R., Xu A. and Wang Y., Mechanisms underlying endothelial dysfunction induced by dietary obesity: role of lipocalin-2, 16th Research Postgraduate Symposium, December 7-8, 2011 Hong Kong. 2011, 90, 2.22.
Tian X.Y., Wong W.T., Xu A., Lu Y., Zhang Y., Wang L., Cheang W.S., Wang Y., Yao X. and Huang Y., Uncoupling protein-2 protects endothelial function in diet-induced obese mice, Circ Res. 2012, 110(9): 1211-6.
Wang Y., Cheng K.Y., Lam K.S.L., Wu D., Wang Y., Huang Y., Vanhoutte P.M.G.R., Sweeney G., Li Y. and Xu A., APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice, Diabetes. 2011, 60: 3044-3054.
Wang Y., Cheng K.Y., Lam K.S.L., Wu D., Wang Y., Huang Y., Vanhoutte P.M.G.R., Sweeney G., Li Y. and Xu A., APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice, Diabetes . 2011, 60(11): 3044-54.
Wang Y., Adipokines – toward the molecular dissection of interactions between stromal adipocytes and breast cancer cells, 18th Hong Kong International Cancer Congress. Hong Kong, 2011.
Wang Y., Lam K.S.L. and Xu A., Adiponectin and Chronic Liver Diseases: an Update, Adiponectin: Production, Regulation and Roles in Disease. NOVA SCIENCE PUBLISHERS, INC., 2011.
Wang Y., ISRN Nutrition, 2012.
Wang Y., Huang B., Song E., Xu A., Feletou M. and Vilaine J.P., Obesity-accelerated arterial aging: interplay between free fatty acids and lipocalin-2, EDHF 2012 - 10th Anniversary Meeting, Vaux-de-Cernay, France, June 27-30, 2012. 49.
Wang Y., Physiology Journal, 2012.
Wang Y., Zeng F., Long C.L., Pan Z.Y., Cui W.Y., Wang R.H. and Liu G.S., The novel ATP-sensitive potassium channel opener iptakalim prevents insulin resistance associated with hypertension via restoring endothelial function, Acta Pharmacologica Sinica. 2011, 32: 1466-1474.
Wong T.W., Tian X.Y., Xu A., Yu J., Lau C.W., Hoo R.L.C., Wang Y., Lee V.W.Y., Lam K.S.L., Vanhoutte P.M.G.R. and Huang Y., Adiponectin is required for PPARgmediated improvement of endothelial function in diabetic mice, Cell Metabolism. 2011, 14: 104-115.
Wong W.T., Tian X.Y., Xu A., Yu J., Lau C.W., Hoo R.L.C., Wang Y., Lee VW , Lam K.S.L., Vanhoutte P.M.G.R. and Huang Y., Adiponectin is required for PPARγ-mediated improvement of endothelial function in diabetic mice, Cell Metabolism. 2011, 14: 104-115.
Xu C., Xu A., Vanhoutte P.M.G.R. and Wang Y., Anti-aging effects of SIRT1 in adipose tissue, 16th Research Postgraduate Symposium, December 7-8, 2011 Hong Kong. 2011, 1.21.
Xu C., Vanhoutte P.M.G.R. and Wang Y., SIRT1 enhances endothelium-dependent relaxation through an eNOS-independent mechanism, Experimental Biology 2012, April 21-25, San Diego, CA. 2012, 189, B116.
Xu G., Ahn J., Chang S., Eguchi M., Ogier A., Han S., Park Y., Shim C., Jang Y., Yang B., Xu A., Wang Y. and Sweeney G., Lipocalin-2 induces cardiomyocyte apoptosis by increasing intracellular iron accumulation, J Biol Chem. 2012, 287(7): 4808-17.
Yang B., Fan P., Xu A., Lam K.S.L., Berger T., Mak T., Tse H.F., Song E., Vanhoutte P.M.G.R. and Wang Y., Improved functional recovery to I/R injury in hearts from lipocalin-2 deficiency mice: Restoration of Mitochondrial Function and Phospholipids Remodeling., American Journal of Translational Research. 2012.
Yang B., Fan P., Xu A., Lam K.S.L., Berger T., Mak T.W., Tse H.F., Yue W., Song E., Vanhoutte P.M.G.R., Sweeney G. and Wang Y., Improved functional recovery to I/R injury in hearts from lipocalin-2 deficiency mice: restoration of mitochondrial function and phospholipids remodeling, Am J Transl Res. 2012, 4(1): 60-71.
Yang B., Vanhoutte P.M.G.R. and Wang Y., Lipocalin-2 mediated myocardial extracellular matrix remodeling is correlated with Akt/P38 activity in hearts, Experimental Biology 2012, April 21-25, San Diego, CA. 2012, 380, S4.
Ye D., Li F.Y.L., Lam K.S.L., Li H., Jia W., Wang Y., Man K., Lo C.M., Li X. and Xu A., Toll-like receptor-4 mediates obesity-induced non-alcoholic steatohepatitis through activation of X-box binding protein-1 in mice, Gut. 2012.
Zhou M., Xu A., Tam P.K.H., Lam K.S.L., Huang B., Liang Y., Lee I.K., Wu D.H. and Wang Y., Upregulation of UCP2 by adiponectin: the involvement of mitochondrial superoxide and hnRNP K, PLoS One. 2012, 7(2): e32349.


Researcher : Wang Y.

Project Title:Molecular mechanisms underlying the hepato-protective functions of the fat cell-derived hormone adiponectin: potential roles of uncoupling protein 2
Investigator(s):Wang Y, Xu A
Department:Biochemistry
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2009
Completion Date:06/2012


Project Title:Protective effect of lipocalin-2 deficiency on aging- and dietary obesity-induced endothelial dysfunction
Investigator(s):Wang Y, Vanhoutte PMGR
Department:Pharmacology
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2010


Project Title:Outstanding Young Researcher Award 2009-10
Investigator(s):Wang Y
Department:Pharmacology
Source(s) of Funding:Outstanding Young Researcher Award
Start Date:12/2010


Project Title:YY1 as a negative regulator of WNT1 gene expression: a role in mammary carcinogenesis
Investigator(s):Wang Y, Xu A
Department:Pharmacology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2011
Completion Date:05/2012


Project Title:Oxidative peptide signatures as potential diagnostic biomarkers for obesity-related diabetes and cardiovascular diseases
Investigator(s):Wang Y, Siu AFM
Department:Pharmacology
Source(s) of Funding:Seed Funding Programme for Applied Research
Start Date:03/2012


Project Title:SIRT1 in cardiometabolic syndrome: Does liver play a role?
Investigator(s):Wang Y, Vanhoutte PMGR
Department:Pharmacology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012


Project Title:The Tenth Anniversary EDHF Meeting - EDHF2012 Obesity-accelerated arterial aging: interplay between free fatty acids and lipocalin-2
Investigator(s):Wang Y
Department:Pharmacology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2012


List of Research Outputs



Researcher : Wong ICK

Project Title:Oral Transmucosal Drug Delivery System for Paediatric and Emergency Medications.
Investigator(s):Wong ICK, Lam JKW, Kwok PCL
Department:Pharmacology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:03/2012


Project Title:EUNETHYDIS 2nd International Conference, entitled "Sharpening the cutting edge of ADHD science and clinical practice", Setting up a progressive observational study to investigate the adverse effects of methylphenidate on children with ADHD in 4 European countries
Investigator(s):Wong ICK
Department:Pharmacology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:05/2012
Completion Date:05/2012


List of Research Outputs

Ahmed U., Spyridis N., Wong I.C.K., Sharland M. and Long P.F., Dosing of oral penicillins in children: is big child=half an adult, small child=half a big child, baby=half a small child still the best we can do?, BMJ. 2011, 343:d7803 doi: 10.1136/bmj.d7803.
Almandil N.B. and Wong I.C.K., Review on the current use of antipsychotic drugs in children and adolescents, Arch Dis Child Educ Pract Ed. 2011, 96(5): 192-6.
Chan M., Wong I.C.K. and Sutcliffe A.G., Prescription drug use in pregnancy: more evidence of safety is needed, The Obstetrician & Gynaecologist. 2012, 14(2): 87-92.
Christie D., Hudson L., Mathiot A., Cole T.J., Karlsen S., Kessel A., Kinra S., Morris S., Nazareth I., Sovio U., Wong I.C.K. and Viner R.M., Assessing the efficacy of the Healthy Eating and Lifestyle Programme (HELP) compared with enhanced standard care of the obese adolescent in the community: study protocol for a randomized controlled trial, Trials. 2011, 12:242.
Hsia Y., Dawoud D., Sutcliffe A.G., Viner R.M., Kinra S. and Wong I.C.K., Unlicensed Use of Metformin in Children and Adolescents in UK, The 6th Asian Conference on Pharmacoepidemiology (ACPE) and 2011 Annual Meeting of the Committee of Pharmacoepidemiology of Chinese Pharmaceutical Association (AMCP-CPA), October 28-30,2011 Beijing, China. 2011.
Hsia Y., Dawoud D., Sutcliffee A.G., Viner R.M., Kinra S. and Wong I.C.K., Unlicensed use of metformin in children and adolescents in the UK., Br J clin Pharmacol. 2012, 73(1): 135-9.
Huynh C., Mortazaee E., Tomlin S., Jani Y., Ghaleb M. and Wong I.C.K., Medicines reconcillation and the point of hospitla discharge for children, Neonatal and Paediatric Pharmacists Group 17th Annual Conference and Exhibition, November 11-13, 2011 Bristol, UK. 2011.
Huynh C., Mortazaee E., Tomlin S., Jani Y., Ghaleb M. and Wong I.C.K., Medicines reconcillation at the point of hospital discharge for children, The 6th Asian Conference on Pharmacoepidemiology (ACPE) and 2011 Annual Meeting of the Committee of Pharmacoepidemiology of Chinese Pharmaceutical Association (AMCP-CPA), October 28-30,2011 Beijing, China. 2011.
Huynh C., Terry D., Tomlin S., Jani Y., Haley H., Smith R., Lowey A., Sinclair A., Wilson K. and Wong I.C.K., The clinical significance of medicines reconciliation in children admitted to hospital, Prescribing and Research in Medicines management (UK & Ireland) Conference 2012, London February 9, 2012.
Huynh C., Jani Y., Tomlin S., Terry D., Sinclair A., Wilson K. and Wong I.C.K., epidemiology of medication discrepancies upon hospital admission in children - a systematic review, Neonatal & Paediatric Pharmacists Group 17th Annual Conference and Exhibition, November 11-13, 2011 Bristol, UK. 2011.
Ibrahim N., Wong I.C.K., Patey S., Tomlin S., Sinha M.D. and Jani Y., Drug-related problem in children with chronic kidney disease, Pediatr Nephrol. 2012, DOI: 10.1007/s00467-012-2149-1.
Iessa N., Murray M.L., Curran S. and Wong I.C.K., Asthma and suicide-related adverse events: a review of observational studies, Eur Respir Rev. 2011, 122: 287-292.
Iessa N., Star K., Wilton L., Curran S., Edwards R., Aronson J., Murray M., Besag F. and Wong I.C.K., Montelukast and Suicide: Causality Assessment Using Spontaneous Reports and Bradford Hill Guidelines, The 6th Asian Confernece on Pharmacoepidemiology (ACPE) and 2011 Annual Meeting of the Committee of Pharmacoepidemiology of Chinese Pharmaceutical Association (AMCP-CPA), October 28-30, 2011 Beijing, China. 2011.
Inglis S.K., Neubert A., Coghill D.R. and Wong I.C.K., Setting up a progressive observational study to investigate the adverse effects of methylphenidate on children with ADHD in 4 European countries, EUNETHYDIS 2nd International ADHD Confernece, May 23-25, 2012 Barcelona, Spain. 2012, 310.
Insuk S., Iessa N., Almandil N., Hsia Y., Murray M. and Wong I.C.K., Increased prescribing of psychotropic drugs to children and adolescents in the UK, The 6th Asian Conference on Pharmacoepidemiology (ACPE) and 2011 Annual Meeting of the Committee of Pharmacoepidemiology of Chinese Pharmaceutical Association (AMCP-CPA), October 28-30,2011 Beijing, China. 2011.
Insuk S., Banaschewski T., Neubert A., Murray M., McCarthy S. and Wong I.C.K., The Attention Deficit Hyperactivity Disorder (ADHD) Data Source Inventory, The 6th Asian Conference on Pharmacoepidemiology (ACPE) and 2011 Annual Meeting of the Committee of Pharmacoepidemiology of Chinese Pharmaceutical Association (AMCP-CPA), October 28-30,2011 Beijing, China. 2011.
Jani Y., Barber N. and Wong I.C.K., Evaluation of Electronic Prescribing in Children, The 6th Asian Conference on Pharmacoepidemiology (ACPE) and 2011 Annual Meeting of the Committee of Pharmacoepidemiology of Chinese Pharmaceutical Association (AMCP-CPA), October 28-30,2011 Beijing, China. 2011.
Jani Y.H., Barber N. and Wong I.C.K., Characteristics of clinical decision support alert overrides in an electronic prescribing system at a tertiary care paediatric hospital, Int J Pharm Pract. 2011, 19:5: 363-366.
Jani Y.H., Barber N. and Wong I.C.K., Republished error management: Paediatric dosing errors before and after electronic prescribing, Postgrad Med J. 2011, 87(1030): 565-8.
Matheson L., Asherson P., Wong I.C.K. and Clifford S., European Psychiatry, 20th European Congress of Psychiatry, Prague, March 30, 2012 Czech Republic. 2012, 27: 1.
McCarthy S., Wilton L., Murray M., Hodgkins P., Asherson P. and Wong I.C.K., Persistence of pharmacological treatment into adulthood for ADHD patients who started treatment in childhood or adolescence in UK primary care, EUNETHYDIS 2nd International ADHD Conference 2012, May 23-25, 2012 Barcelona, Spain. 2012, 318.
McCarthy S., Wilton L., Murray M., Hodgkins P., Asherson P. and Wong I.C.K., Persistence of pharmacological treatment into adulthood for ADHD patients who started treatment in childhood or adolescence in UK primary care, The 6th Asian Conference on Pharmacoepidemiology (ACPE) and 2011 Annual Meeting of the Committee of Pharmacoepidemiology of Chinese Pharmaceutical Association (AMCP-CPA), October 28-30,2011 Beijing, China. 2011.
McCarthy S., Wilton L., Murray M.L., Hodgkins P., Asherson P. and Wong I.C.K., The epidemiology of pharmacologically treated attention deficit hyperactivity disorder (ADHD) in children, adolescents and adults in UK primary care., BMC Pediatr. 2012, 12:78.
McCarthy S., Wilton L., Murray M., Hodgkins P., Asherson P. and Wong I.C.K., Theepidemiology of pharmacologically-treated attention deficit hyperactivity disorder (ADHD) in children, adolescents and adults in UK primary care, The 6th Asian Conference on Pharmacoepidemiology (ACPE) and 2011 Annual Meeting of the Committee of Pharmacoepidemiology of Chinese Pharmaceutical Association (AMCP-CPA), October 28-30,2011 Beijing, China. 2011.
Neubert A., Hsia Y., de Jong-van den Berg L.T., Janhsen K., Glaeske G., Furu K., Kieler H., Norgaard M., Clavenna A. and Wong I.C.K., Comparison of Anti-diabetic drug prescribing in children and adolescents in seven European Countries, The 6th Asian Conference on Pharmacoepidemiology (ACPE) and 2011 Annual Meeting of the Committee of Pharmacoepidemiology of Chinese Pharmaceutical Association (AMCP-CPA), October 28-30,2011 Beijing, China. 2011.
Neubert A., Hsia Y., de Jong-van den Berg L.T., Janhsen K., Glaeske G., Furu K., Kieler H., Norgaard M., Clavenna A. and Wong I.C.K., Comparison of anti-diabetic drug prescribing in children and adolescents in seven European countries., Br J Clin Pharmacol. 2011, 72(6): 969-77.
Porta A., Hsia Y., Doerholt K., Spyridis N., Bielicki J., Menson E., Tsolia M., Esposito S., Wong I.C.K. and Sharland M., Comparing neonatal and paediatric antibiotic prescribing between hospitals: a new algorithm to help international benchmarking., J Antimicrob Chemother. 2012, 67: 1278-1286.
Rani F.A., Byrne P., Cranswick N., Murray M.L. and Wong I.C.K., Mortality in children and adolescents prescribed antipsychotic medication: a retrospective cohort study using the UK general practice research database, Drug Saf. 2011, 34(9): 773-781.
Rashed A., Wong I.C.K., Cranswick N., Tomlin S., Rascher W. and Neubert A., Risk factors associated with adverse drug reactions in hospitalised children: an international multicentre study (ADVISE), 13th Biannual Congress of the European Society for Developmental Perinatal and Paediatric Pharmacology (ESDP): Drug Therapy in Neonates and Children - Recent Advances, Oslo, Norway, June 15-17, 2011.
Rashed A., Wong I.C.K., Cranswick N., Tomlin S., Rascher W. and Neubert A., Risk factors associated with adverse drug reactions in hospitalised children, The 6th Asian Conference on Pharmacoepidemiology (ACPE) and 2011 Annual Meeting of the Committee of Pharmacoepidemiology of Chinese Pharmaceutical Association (AMCP-CPA), October 28-30,2011 Beijing, China. 2011.
Rashed A.N., Wong I.C.K., Cranswick N., Tomlin S., Lee K., Chua S.S., Rascher W. and Neubert A., ADVISE: adverse drug reactions in children - International surveillance and evaluation: a multicentre cohort study , PRIMM: Prescribing and Research in Medicines Management (UK & Ireland), ADRs: 'Is the patient voice loud enough/' International Conference, June 26, 2011, Friend House, London. Published in Pharmacoepidemiol Drug Saf. 2011, Doi: 10.1002/pds.2222.
Rashed A.N., Wong I.C.K., Cranswick N., Hefele B., Tomlin S., Jackman J., Lee K., Hon K.L., Ong J., Ghaleb M., Chua S.S., Hui T.M., Rascher W. and Neubert A., Adverse Drug Reactions in Children – International Surveillance and Evaluation (ADVISE): A Multicentre Cohort Study, Drug Saf.. 2012, 35(6): 481-494.
Rashed A.N., Neubert A., Tomlin S., Jackman J., Alhamdan H., Shaikh A., Attar A., Aseen M. and Wong I.C.K., Drug-related problems in hospitalised children in United Kingdom and Saudi Arabia, The 6th Asian Conference on Pharmacoepidemiology (ACPE) and 2011 Annual Meeting of the Committee of Pharmacoepidemiology of Chinese Pharmaceutical Association (AMCP-CPA), October 28-30,2011 Beijing, China. 2011.
Rashed A.N., Neubert A., Tomlin S., Jackman J., Alhamdan H., Shaikh A., Attar A., Aseeri M. and Wong I.C.K., Drug-related problems in hospitalised children in the United Kingdom and Saudi Arabia, 11th International Society of Pharmacovgilance (ISOP) Annual Meeting, October 26-28, 2011 Istanbul, Turkey. Published in Drug Saf. 2011, 34(10): 983.
Rashed A.N., Neubert A., Tomlin S., Jackman J., Alhamdan H., Alshaikh A., Attar A., Aseeri M., Wilton L. and Wong I.C.K., Epidemiology and potential associated risk factors of drug-related problems in hospitalised children in the United Kingdom and Saudi Arabia., Eur J Clin Pharmacol. 2012, DOI 10.1007/s00228-012-1302-x.
Rashed A.N., Wong I.C.K., Cranswick N., Tomlin S., Rascher W. and Neubert A., Risk factors associated with adverse drug reactions in hospitalised children: international multicentre study, Eur J Clin Pharmacol. 2011, 68(5): 801-810.
Star K., Almandil N.B., Wong I.C.K., Strandell J. and Edwards R., Individual Case Safety Reports and Useful Clinical Information, The 11th International society of pharmcovigilance (ISOP) Annual Meeting, October 26-28, 2011 Istanbul, Turkey. 2011.
Wong I.C.K., Managing epilepsy: what pharmacists need to know, Clinical Pharmacist. 2012, 4: 52-53.
Wong I.C.K., Medication Safety in Children, The Forbidden City International Pharmacist Forum, May 11-14, 2012 Beijing China. 2012.
Wong I.C.K., Planting the Seed - Training the Next Generation of HK Pharmacists, Hong Kong Pharmacy Conference 2012, Hong Kong Convention and Exhibition Center, February 4, 2012, Hong Kong. 2012.
Wong I.C.K., Worldwide Pharmacovigilance Using the WHO Global Individual Case Safety Report Database, VigiBase, Third Annual Symposium on Pharmacovigilance, March 19, 2012 Shatin, Hong Kong. 2012.


Researcher : Worsley AJ

List of Research Outputs

Anderson R.J., Groundwater P.W., Todd A. and Worsley A.J., In: Anderson RA, Groundwater PW, Todd A, Worsley AJ, Antibacterial Agents. Chemistry, Mode of Action, Mechanisms of Resistance and Clinical Applications. John Wiley & Sons, 2012.


Researcher : Xu A

Project Title:Molecular mechanism underlaying the pathogenesis of type 2 diabetes
Investigator(s):Xu A
Department:Medicine
Source(s) of Funding:Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:05/2007


Project Title:Vascular dysfunction in obesity and diabetes: from risk prediction to therapeutic intervention
Investigator(s):Xu A, Lam KSL, Vanhoutte PMGR, Tse HF, Wang Y
Department:Medicine
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:06/2008


Project Title:Adipocyte fatty acid binding protein as a novel diagnostic marker and therapeutic target to combat vascular complications of diabetes: mechanisms and clinical implications
Investigator(s):Xu A, Vanhoutte PMGR, Lam KSL
Department:Medicine
Source(s) of Funding:NSFC/RGC Joint Research Scheme
Start Date:01/2009
Completion Date:12/2011


Project Title:Protective roles of AMP-activated protein kinase against vascular disease in diabetes: Molecular mechanisms and therapeutic intervention
Investigator(s):Xu A, Vanhoutte PMGR
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2009
Completion Date:12/2011


Project Title:Characterization of Novel Adaptor Proteins Involved in Regulating Insulin Sensitivity and Glucose Homeostasis: from Molecular Mechanism to Physiological Implication
Investigator(s):Xu A
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2010


Project Title:APPL2 as a Negative Regulator of Insulin Sensitivity and Glucose Uptake in Skeletal Muscle: A Novel Pathway Leading to Insulin Resistance?
Investigator(s):Xu A
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2011


Project Title:Genetic and pathogenic pathways leading to type 2 diabetes Mellitus
Investigator(s):Xu A
Department:Medicine
Source(s) of Funding:Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:05/2011


Project Title:Protective effects of the liver-derived hormone adropin against obesity-related insulin resistance and metabolic disorders
Investigator(s):Xu A, Wang Y
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2011
Completion Date:04/2012


Project Title:71th Scientific Sessions of the American Diabetes Association Genetic Inactivation of Toll-Like Receptor 4 Alleviates Diet-Induced Nonalcoholic Steatohepatitis by Inhibiting Reactive Oxygen Species-Evoked Activation of X-box Binding Protein-1 in ApoE-Deficient Mice
Investigator(s):Xu A
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2011


Project Title:A Multi-disciplinary Approach to Investigate Vascular Dysfunction in Obesity and Diabetes: From Molecular Mechanism to Therapeutic Intervention
Investigator(s):Xu A, Vanhoutte PMGR, Wang Y, Lam KSL
Department:Medicine
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:06/2011


Project Title:The Liver-derived Hormone FGF21 as a Novel Regulator of Vascular Function: Molecular Basis and Physiological Implications
Investigator(s):Xu A, Vanhoutte PMGR
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2012


Project Title:The Ubiquitin Ligase Mdm2 as a Novel Regulator of Adipose Functions and Obesity
Investigator(s):Xu A, Cheng KY
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012


Project Title:EDHF 2012 ENDOTHELIUM-SELECTIVE ACTIVATION OF AMP-ACTIVATED PROTEIN KINASE IMPROVES RE-ENDOTHELIALIZATION AND VASCULAR FUNCTION VIA INDUCTION OF HEME OXYGENASE-1 IN DIABETIC MICE
Investigator(s):Xu A
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2012


List of Research Outputs

Chow H.M., Liu J., Sun R.W.Y., Vanhoutte P.M.G.R., Xu A., Chen J., Che C.M. and Wang Y., The gold (III) porphyrin complex, gold-2a, supresses WNT1 expression in breast cancer cells by enhancing the promoter association of YY1, American Journal of Translational Research. 2011, 3: 479-491.
Liang C., Man R.Y.K. and Xu A., Loss of function in toll-like receptor 4 curtails endothelial dysfunction in genetically obese mice, Fourth Scientific Meeting of the Asian Society for Vascular Biology, Hong Kong 20-21 November, 2010. 2011, 29.
Liu J., Xu A., Lam K.S.L., Wong N.S., Chen J., Shepherd P.R. and Wang Y., Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation, 18th Hong Kong International Cancer Congress. 2011.
Liu J., Xu A., Lam K.S.L., Wong N.S., Chen J., Sheperd P.R. and Wang Y., Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation, The 18th Hong Kong International Cancer Conference. 2011.
Liu J., Xu A., Lam K.S.L., Wong N.S., Chen J., Shepherd P.R. and Wang Y., Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation, The 18th Hong Kong International Cancer Conference. 2011.
Liu T.C., Song E., Xu A., Berger T., Mak T., Tse H.F., Law K.M., Huang B., Vanhoutte P.M.G.R. and Wang Y., Lipocalin-2 deficiency prevents endothelial dysfunction associated with dietary obesity: role of cytochrome P450 2C inhibition., British Journal of Pharmacology. 2011.
Wang T., Qiao S., Lei S., Liu Y., Ng J.K.F., Ng J.K.F., Xu A., Xu A., Lam K.S.L., Irwin M.G. and Xia Z., N-acetylcysteine and allopurinol synergistically enhance cardiac adiponectin content and reduce myocardial reperfusion injury in diabetic rats, PLoS One. 2011, 6(8): e23967.
Wang Y., Lam K.S.L. and Xu A., Adiponectin and Chronic Liver Diseases: an Update, Adiponectin: Production, Regulation and Roles in Disease. NOVA SCIENCE PUBLISHERS, INC., 2011.
Wong T.W., Tian X.Y., Xu A., Yu J., Lau C.W., Hoo R.L.C., Wang Y., Lee V.W.Y., Lam K.S.L., Vanhoutte P.M.G.R. and Huang Y., Adiponectin is required for PPARgmediated improvement of endothelial function in diabetic mice, Cell Metabolism. 2011, 14: 104-115.


Researcher : Xu C

List of Research Outputs

Bai B., Liang Y., Xu C., Xu A.M., Kee M., Vanhoutte P.M.G.R. and Wang Y., CDK5 mediates SIRT1 phosphorylation at serine 47 during endothelial senescence, 16th Research Postgraduate Symposium, December 7-8, 2011 Hong Kong. 2011, 2.01.
Bai B., Liang Y., Xu C., Lee M.Y.K., Xu A., Wu D., Vanhoutte P.M.G.R. and Wang Y., CDK5-Mediated Hyperphosphorylation of SIRT1 Contributes to the Development of Endothelial Senescence and Atherosclerosis, Circulation. 2012.
Xu C., Xu A., Vanhoutte P.M.G.R. and Wang Y., Anti-aging effects of SIRT1 in adipose tissue, 16th Research Postgraduate Symposium, December 7-8, 2011 Hong Kong. 2011, 1.21.
Xu C., Vanhoutte P.M.G.R. and Wang Y., SIRT1 enhances endothelium-dependent relaxation through an eNOS-independent mechanism, Experimental Biology 2012, April 21-25, San Diego, CA. 2012, 189, B116.


Researcher : Yang B

List of Research Outputs

Xu G., Ahn J., Chang S., Eguchi M., Ogier A., Han S., Park Y., Shim C., Jang Y., Yang B., Xu A., Wang Y. and Sweeney G., Lipocalin-2 induces cardiomyocyte apoptosis by increasing intracellular iron accumulation, J Biol Chem. 2012, 287(7): 4808-17.
Yang B., Fan P., Xu A., Lam K.S.L., Berger T., Mak T., Tse H.F., Song E., Vanhoutte P.M.G.R. and Wang Y., Improved functional recovery to I/R injury in hearts from lipocalin-2 deficiency mice: Restoration of Mitochondrial Function and Phospholipids Remodeling., American Journal of Translational Research. 2012.
Yang B., Fan P., Xu A., Lam K.S.L., Berger T., Mak T.W., Tse H.F., Yue W., Song E., Vanhoutte P.M.G.R., Sweeney G. and Wang Y., Improved functional recovery to I/R injury in hearts from lipocalin-2 deficiency mice: restoration of mitochondrial function and phospholipids remodeling, Am J Transl Res. 2012, 4(1): 60-71.
Yang B., Vanhoutte P.M.G.R. and Wang Y., Lipocalin-2 mediated myocardial extracellular matrix remodeling is correlated with Akt/P38 activity in hearts, Experimental Biology 2012, April 21-25, San Diego, CA. 2012, 380, S4.


Researcher : Yang B

List of Research Outputs

Xu G., Ahn J., Chang S., Eguchi M., Ogier A., Han S., Park Y., Shim C., Jang Y., Yang B., Xu A., Wang Y. and Sweeney G., Lipocalin-2 induces cardiomyocyte apoptosis by increasing intracellular iron accumulation, J Biol Chem. 2012, 287(7): 4808-17.
Yang B., Fan P., Xu A., Lam K.S.L., Berger T., Mak T., Tse H.F., Song E., Vanhoutte P.M.G.R. and Wang Y., Improved functional recovery to I/R injury in hearts from lipocalin-2 deficiency mice: Restoration of Mitochondrial Function and Phospholipids Remodeling., American Journal of Translational Research. 2012.
Yang B., Fan P., Xu A., Lam K.S.L., Berger T., Mak T.W., Tse H.F., Yue W., Song E., Vanhoutte P.M.G.R., Sweeney G. and Wang Y., Improved functional recovery to I/R injury in hearts from lipocalin-2 deficiency mice: restoration of mitochondrial function and phospholipids remodeling, Am J Transl Res. 2012, 4(1): 60-71.
Yang B., Vanhoutte P.M.G.R. and Wang Y., Lipocalin-2 mediated myocardial extracellular matrix remodeling is correlated with Akt/P38 activity in hearts, Experimental Biology 2012, April 21-25, San Diego, CA. 2012, 380, S4.


Researcher : Yang C

List of Research Outputs

Li R.W.S., Yang C., Sit S.M., Lin Y.T., Ho Y.W. and Leung G.P.H., Physiological and Pharmacological roles of Vascular Nucleoside Transporters, J Cardiovasc Pharmacol. 2012, 59: 10-15.
Li R.W.S., Yang C., Sit S.M., Lin Y.T., Ho Y.W. and Leung G.P.H., Physiological and Pharmacological roles of vascular nucleoside transporters., Journal of Cardiovascular Pharmacology . 2012, 59: 10-15.


Researcher : Yang C

List of Research Outputs

Li R.W.S., Yang C., Sit S.M., Lin Y.T., Ho Y.W. and Leung G.P.H., Physiological and Pharmacological roles of Vascular Nucleoside Transporters, J Cardiovasc Pharmacol. 2012, 59: 10-15.
Li R.W.S., Yang C., Sit S.M., Lin Y.T., Ho Y.W. and Leung G.P.H., Physiological and Pharmacological roles of vascular nucleoside transporters., Journal of Cardiovascular Pharmacology . 2012, 59: 10-15.


Researcher : Zhang Y

List of Research Outputs

Zhang Y., Leung S.W.S. and Man R.Y.K., Effects of luteolin on endothelium-dependent relaxation is different between male and female rat mesenteric arteries: relationship with endothelium-derived hyperpolarizing factor and cyclooxygenase pathways, Fifteenth Annual Scientific Meeting of The Institute of Cardiovascular Science and Medicine, September 17, 2011 Hong Kong, 2011, 7 . 2011.
Zhang Y., Leung S.W.S. and Man R.Y.K., Gender-specific Relaxation of Flavonoids in Rat Mesenteric Arteries, 15th Research Postgraduate Symposium, Hong Kong, December 1-2, 2010. 2011, 100.
Zhang Y., Leung S.W.S. and Man R.Y.K., Gender-specific effects of luteolin in the enhancement of endothelium-dependent relaxation in 45-50 weeks old rat mesenteric arteries: role of endothelium-derived hyperpolarizing factors and cyclooxygenase, Chinese Journal of Pharmacology and Toxicology, HKPS / CPS Jointly Meeting, September 23-25, 2011 Jinan China. 2011, 25: 139.
Zhang Y., Leung S.W.S. and Man R.Y.K., Gender-specific relaxation of flavonoids in rat's mesenteric arteries, Fourth Scientific Meeting of the Asian Society for Vascular Biology, Hong Kong 20-21 November, 2010. 2011, 33.


Researcher : Zhao Y

List of Research Outputs

Zhao Y., Leung S.W.S. and Vanhoutte P.M.G.R., Activation of A1-adrenergic receptors causes thromoxane-prostanoid receptor desensitization in the aorta of the spontaneously hypertensive rat, Fifteenth Annual Scientific Meeting of The Institute of Cardiovascular Science and Medicine, September 17, 2011 Hong Kong. 2011, 12.
Zhao Y., Chan K.Y.C., Liao S., Tse H.F., Leung S.W.S., Xu A. and Vanhoutte P.M.G.R., Apocynin and BMS309403 reduce dysfunction of regenerated endothelium of the pig coronary artery, Seventh International Symposium on Healthy Aging of the Research Centre of Heart, Brain, Hormone and Healthy Aging, March 3-4, 2012, Hong Kong. 2012, 70.
Zhao Y., Leung S.W.S. and Vanhoutte P.M.G.R., Endothelial NOS-Independent Release of Nitric Oxide in the Aorta of the Spontaneously Hypertensive Rat , 16th Research Postgraduate Symposium, December 7-8, 2011 Hong Kong. 2011, 95, 2.32.
Zhao Y., Leung S.W.S. and Vanhoutte P.M.G.R., Endothelial NOS-independent release of nitric oxide in the aorta of the spontaneously hypertensive rat, Chinese Journal of Pharmacology and Toxicology, HKPS / CPS Jointly Meeting, September 23-25, 2011, Jinan China. 2011, 25: 140.
Zhao Y., Leung S.W.S. and Vanhoutte P.M.G.R., Endothelial NOS-independent release of nitric oxide in the aorta of the spontaneously hypertensive rat, Experimental Biology 2012, April 21-25, San Diego, CA. 2012, 259, 840.1.


Researcher : Zhou M

List of Research Outputs

Zhou M., Xu A., Tam P.K.H., Lam K.S.L., Huang B., Liang Y., Lee I.K., Wu D.H. and Wang Y., Upregulation of UCP2 by adiponectin: the involvement of mitochondrial superoxide and hnRNP K, PLoS One. 2012, 7(2): e32349.


Researcher : Zou Q

List of Research Outputs

Zou Q. and Vanhoutte P.M.G.R., Activation of Nicotinic Receptors Contributes to Acetylcholine Induced Endothelium-dependent Relaxations in the Aorta of the Spontaneous Hypertensive Rat, 15th Research Postgraduate Symposium, Hong Kong, December 1-2, 2011. 102.
Zou Q. and Vanhoutte P.M.G.R., Activation of n-AChRs contributes to endothelium-dependent relaxations in the rat aorta, Chinese Journal of Pharmacology and Toxicology, HKPS / CPS Jointly Meeting, September 23-25, 2011 Jinan China. 2011, 25: 140.
Zou Q., Leung S.W.S. and Vanhoutte P.M.G.R., Activation of nicotinic receptors can contribute to endothelium-dependent relaxations to acetylcholine in the rat aorta, The Journal of Pharmacology and Expermental Therapeutics. 2012, 341: 756-763.


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