DEPT OF PHYSIOLOGY
| Researcher : Bourreau JP |
| Project Title: | Role of cyclooxygenase in the ventricular effects of adrenomedullin: does prostacyclin contribute towards the cardiodepression in the late hypodynamic phase of septic shock? |
| Investigator(s): | Bourreau JP |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2003 |
| Project Title: | Switch in G-protein coupling. Role of intracellular cAMP |
| Investigator(s): | Bourreau JP |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2006 |
| Researcher : Chan YS |
| Project Title: | 30th Annual Conference of Society for Neuroscience Expression of N-Methyl-D-Aspartate Receptor Subunits and Induction of c-fos in Otolith Neurons in the Vestibular Nuclei of Postnatal Rats |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2000 |
| Project Title: | 31st Annual Meeting of Society for Neuroscience Expression of Neurotrophin Receptors in Vestibular Nuclei During the Postnatal Development of the Rat |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2001 |
| Project Title: | XXIV Annual Conference of Indian Academy of Neurosciences Development Refinement of Spatial Recognition Circuits |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 12/2006 |
| Project Title: | Role of the thalamus in integrating spatial information and guiding navigation |
| Investigator(s): | Chan YS |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2009 |
| Project Title: | Outstanding Research Student Supervisor Award 2009-10 |
| Investigator(s): | Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | Outstanding Research Student Supervisor Award |
| Start Date: | 12/2010 |
| Project Title: | Serotonin-induced bidirectional modulation of activity-dependent synaptic plasticity tunes vestibular functions |
| Investigator(s): | Chan YS, Shum DKY |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2013 |
| Project Title: | Orexin-induced modulation of activity-dependent synaptic plasticity is critical for the maturation of vestibular circuitry and functions |
| Investigator(s): | Chan YS, Shum DKY, Lai CH |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2015 |
| Project Title: | Semaphorin and perineuronal nets regulate developmental plasticity of central vestibular circuitry |
| Investigator(s): | Chan YS, Shum DKY |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2015 |
| Project Title: | Neuronal Mechanism of Cholecystokinin-Facilitated Cross-modal Learning and Memory |
| Investigator(s): | Chan YS |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 06/2016 |
| Project Title: | Remodeling the sulfation pattern of perineuronal nets in the entorhinal cortical circuit prevents stress-induced decline in learning and memory |
| Investigator(s): | Chan YS, Lai SWC, Shum DKY |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2016 |
| Project Title: | Integration of new neurons into the mature vestibular circuitry requires GABAergic signaling for relevant outcome in behavior |
| Investigator(s): | Chan YS, Lai SWC, Shum DKY |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 07/2016 |
| Project Title: | HKU Centennial Distinguished Chinese Scholars Scheme 2016-17 |
| Investigator(s): | Chan YS |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | HKU Centennial Distinguished Chinese Scholars Scheme |
| Start Date: | 09/2016 |
| Project Title: | Society for Neuroscience 46th Annual Meeting 2016; Prevation of Schwann cell identity in vitro through bone morphogenetic protein signaling |
| Investigator(s): | Chan YS |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2016 |
| Completion Date: | 11/2016 |
| Researcher : Cheung KH |
| Project Title: | Nuclear Membrane Electrophysiology of Ryanodine Receptor And Its Regulation by cADPR |
| Investigator(s): | Cheung KH, Chen J |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2013 |
| Completion Date: | 02/2017 |
| Project Title: | Electrophysiological Characterization of the Two-Pore Channel 2 |
| Investigator(s): | Cheung KH |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2014 |
| Completion Date: | 02/2017 |
| Project Title: | Role of TMEM16A in the formation of epididymal microenvironment |
| Investigator(s): | Cheung KH |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2015 |
| Project Title: | Role of presenilin-1 in pancreatic beta-cell insulin secretion |
| Investigator(s): | Cheung KH |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2016 |
| Researcher : Hao Q |
| Project Title: | Investigation of pathogenesis mechanism of two infectious fungi Penicillium marneffei and Aspergillus fumigatus |
| Investigator(s): | Hao Q |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2014 |
| Project Title: | Novel Structure and Function of Human Sirtuins |
| Investigator(s): | Hao Q, Huang J, Li XD |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 03/2015 |
| Project Title: | Structural study of NDM-1: Towards rational inhibitor design against the antibiotic resistant “superbug” |
| Investigator(s): | Hao Q |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 05/2016 |
| Project Title: | Development of novel inhibitors targeting the resistance mechanisms of clinical superbugs |
| Investigator(s): | Hao Q |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 06/2017 |
| List of Research Outputs |
| GUO Z., CHAN W.H.Y., Kong K.W.G., Hao Q. and Chye M.L., 2017. The first plant acyl-CoA-binding protein structures: the close homologues OsACBP1 and OsACBP2 from rice, Acta Cryst.. 2017, D73: 438-448. |
| Researcher : Keung WWY |
| Project Title: | Driving maturation of human embryonic stem cell-derived cardiomyocytes through metabolic conditioning in 2D and 3D environment |
| Investigator(s): | Keung WWY |
| Department: | Physiology |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 09/2014 |
| Completion Date: | 09/2016 |
| Project Title: | Modeling cardiomyopathy with 3D cardiac tissue constructs of patient specific induced-pluripotent stem cells |
| Investigator(s): | Keung WWY |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2016 |
| Researcher : LU L |
| List of Research Outputs |
| WU T.H.E., LU L., WANG Y. and Ballard H.J., Connexin 43, Pannexin 1 and Cystic Fibrosis Transmembrane Conductance Regulator in the Regulation of ATP Release From Muscle, 21st Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2016. |
| Researcher : Leung CFP |
| Project Title: | Regulation of CD38 in abscisic acid-activated human monocytes. |
| Investigator(s): | Leung CFP, Lee HC |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2009 |
| Researcher : Lung MAKY |
| Project Title: | Endothelins in nasal mucosa: role in nasal congestion and decongestion |
| Investigator(s): | Lung MAKY |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2004 |
| Researcher : Lung MKY |
| Project Title: | Endothelins in nasal mucosa: role in nasal congestion and decongestion |
| Investigator(s): | Lung MAKY |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2004 |
| Researcher : PANG B |
| List of Research Outputs |
| PANG B., Cheung N.N., ZHANG W., Dai J., Kao R.Y.T., Zhang H. and Hao Q., Structural Characterization of H1N1 Nucleoprotein-Nucleozin Binding Sites, Scientific Reports. 2016, 6: 29684. |
| Researcher : Ren L |
| List of Research Outputs |
| Keung W.W.Y., Ren L., Li S., Wong A.O., Chopra A., Kong M.C.W., Tomaselli G.F., Chen C.S. and Li R.A., Non-cell autonomous cues for enhanced functionality of human embryonic stem cell-derived cardiomyocytes via maturation of sarcolemmal and mitochondrial KATP channels, Scientific Reports. 2016, 6: 34154. |
| Researcher : Shiu SYW |
| Project Title: | Investigating potential signaling interactions between melatonin MT1 receptor and melatonin-related GPR50 receptor, and profiling melatonin-induced genome-wide transcriptional changes in prostate cancer |
| Investigator(s): | Shiu SYW |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2014 |
| Completion Date: | 11/2016 |
| Project Title: | Exploring melatonin receptor signaling in human retinal pigment epithelial cells |
| Investigator(s): | Shiu SYW |
| Department: | School of Biomedical Sciences |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 04/2015 |
| Researcher : Tsui YP |
| Project Title: | Axonal regulation of peripheral nervous system glia identity |
| Investigator(s): | Tsui YP, Chan YS |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2015 |
| Completion Date: | 08/2016 |
| Researcher : Wang Y |
| Project Title: | Structural basis of sirt6 catalytic mechanism investigation and the inhibitors design |
| Investigator(s): | Wang Y, Hao Q |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2015 |
| Completion Date: | 08/2016 |
| Researcher : Wong TM |
| Project Title: | First Asia-Pacific Opioid Symposium Cardioprotective Effects of K-Opioids |
| Investigator(s): | Wong TM |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2000 |
| Project Title: | Outstanding Research Student Supervisor Award 2001-2002 |
| Investigator(s): | Wong TM |
| Department: | Anaesthesiology |
| Source(s) of Funding: | Outstanding Research Student Supervisor Award |
| Start Date: | 06/2002 |
| Project Title: | XVIII World Congress International Society for Heart Research in Conjunction with 52nd Annual Scientific Meeting of the Cardiac Society of Australia & New Zealand Delayed Cardioprotection of Kappa Opioid Receptor Stimulation in Normal and Diabetic Rats - Roles of Heat Shock Protein 70 and Intracellular Ca2+ |
| Investigator(s): | Wong TM |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2004 |
| Project Title: | CSANZ 2006 Annual Scientific Meeting Heat Shock Protein 70, Calcium Regulation and Cardiac Survival |
| Investigator(s): | Wong TM |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2006 |
| Researcher : Yue J |
| Project Title: | The role of NAADP/two-pore channel 2/Ca2+ signaling in regulating neural differentiation of mouse embryonic stem cells |
| Investigator(s): | Yue J, Wu W |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2011 |
| Project Title: | 2013 ASBMB Annual Meeting; The NAADP/ TPC2/Ca2+ Signaling Antagonizes Autophagosome Maturation |
| Investigator(s): | Yue J |
| Department: | Physiology |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2013 |
| Project Title: | Dissecting the Mechanism and Function of TPC2 Signaling in Autophagy Maturation in Mammalian Cells |
| Investigator(s): | Yue J, Wu W |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2013 |
| Project Title: | Applying a Novel cADPR Photoaffinity Labelling Analogue to Dissect the Cyclic ADP-Ribose (cADPR)-Ca2+ Signaling in Mammalian Cells |
| Investigator(s): | Yue J, Cheung KH |
| Department: | Physiology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2014 |
| Researcher : ZHANG W |
| List of Research Outputs |
| PANG B., Cheung N.N., ZHANG W., Dai J., Kao R.Y.T., Zhang H. and Hao Q., Structural Characterization of H1N1 Nucleoprotein-Nucleozin Binding Sites, Scientific Reports. 2016, 6: 29684. |
| Wang Y., Fung E.Y.M., ZHANG W., He B., CHUNG W.H., Jin J., Hu J., Lin H.N. and Hao Q., Deacylation Mechanism by SIRT2 Revealed in the 1′-SH-2′-O-Myristoyl Intermediate Structure, Cell Chemical Biology. 2017, 24: 339-345. |
| Researcher : Zhang H |
| List of Research Outputs |
| HU M., Zhang H., Liu Q. and Hao Q., Structural Basis for Human PECAM-1-Mediated Trans-homophilic Cell Adhesion, Scientific Reports. 2016, 6: 38655. |
| PANG B., Cheung N.N., ZHANG W., Dai J., Kao R.Y.T., Zhang H. and Hao Q., Structural Characterization of H1N1 Nucleoprotein-Nucleozin Binding Sites, Scientific Reports. 2016, 6: 29684. |
| Researcher : Zhao Y |
| Project Title: | Characteristics and potential regulatory mechanisms of a cytosolic CD38 |
| Investigator(s): | Zhao Y, Lee HC |
| Department: | Physiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2011 |