DEPT OF PAEDIATRICS & ADOLESCENT MED
| Researcher : CHEN Q |
| List of Research Outputs |
| CHEN Q., Liu Y., Lv A., NI K., Xiang Z., WEN K. and Tu W., Influenza virus infection exacerbates experimental autoimmune encephalomyelitis disease by promoting type I T cells infiltration into central nervous system, Journal of Autoimmunity. 2017, 77: 1-10. |
| Researcher : CHEN R |
| List of Research Outputs |
| CHEN R., Lau Y.L., Zhang Y. and Yang W., SRinversion: a tool for detecting short inversions by splitting and re-aligning poorly mapped and unmapped sequencing reads, Bioinformatics. Oxford University Press, 2016, 32: 3559-3565. |
| Morris D.L., Sheng Y., Zhang Y., WANG Y., Zhu Z., Tombleson P., Chen L., Cunninghame Graham D.S., Bentham J., Roberts A.L., CHEN R., Zuo X., WANG T., Wen L., Yang C., Liu L., Yang L., Li F., Huang Y., Yin X., Yang S., Rönnblom L., Fürnrohr B.G., Voll R.E., Schett G., Costedoat-Chalumeau N., Gaffney P.M., Lau Y.L., Zhang X X., Yang W., Cui Y. and Vyse T.J., Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus., Nature Genetics. 2016, 48: 940–946. |
| Zhou X.J., Nath S.K., Qi Y.Y., Sun C., Hou P., Zhang Y.M., Lv J.C., Shi S.F., Liu L.J., CHEN R., Yang W., He K.Z., Li Y. and Zhang H., Novel identified associations of RGS1 and RASGRP1 variants in IgA Nephropathy., Scientific Reports. 2016. |
| Researcher : CHONG CH |
| List of Research Outputs |
| CHONG C.H., NG C.P., Mak H.S., Li Q., McAlonan G.M. and Chan S.Y., LRRC7 regulates neurite morphogenesis through mGluR5, Annual Meeting of Neuroscience 2016 (San Diego, USA). 2016. |
| Researcher : Chan GCF |
| Project Title: | Review of local experience in the management of childhood myelodysplastic syndrome |
| Investigator(s): | Chan GCF |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Other Funding Scheme |
| Start Date: | 01/2001 |
| Project Title: | Treatment protocol for childhood medulloblastoma in Hong Kong |
| Investigator(s): | Chan GCF |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Other Funding Scheme |
| Start Date: | 01/2001 |
| Project Title: | Survey on the prevalence on use of alternative medical treatment in paediatric patients |
| Investigator(s): | Chan GCF |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Other Funding Scheme |
| Start Date: | 09/2001 |
| Project Title: | Direct generation and functional characterization of human dendritic cells derived from bone marrow cells of leukemic origins |
| Investigator(s): | Chan GCF, Chiu CSW, Ma ESK, Huang F |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Other Funding Scheme |
| Start Date: | 07/2002 |
| Project Title: | King's/HKU Fellowship Awards 2009-10 |
| Investigator(s): | Chan GCF |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | King's/HKU Fellowship Awards |
| Start Date: | 09/2009 |
| Project Title: | Molecular diagnosis for Childhood Cancers: Defining the Prognosis and Stratifying the Proper Treatments |
| Investigator(s): | Chan GCF, Tam PKH |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 01/2014 |
| Project Title: | Human Mesenchymal Stem Cells as a Therapeutic Modality for Graft Versus Host Disease Murine Models |
| Investigator(s): | Chan GCF |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2014 |
| Project Title: | A two-arm, randomized, double-blind, placebo-controlled trial to investigate the efficacy and safety of Everolimus (mTOR inhibitor) in pediatric patients with tuberous sclerosis and epilepsy requiring anticonvulsant treatments |
| Investigator(s): | Chan GCF, Yung AWY, Khong PL |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 09/2015 |
| Project Title: | The healing effects of mesenchymal stem cell or its soluble factors on cutaneous burn injury |
| Investigator(s): | Chan GCF, Li CB, Chan S |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2016 |
| Project Title: | Automated bioreactors for expanding and monitoring mesenchymal stem cells |
| Investigator(s): | Chan GCF, Li CB, Deng R |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Matching Grant for Joint Research |
| Start Date: | 10/2016 |
| Project Title: | Investigation of Sustained Expression of Human Factor IX by Genetic Modified Human Mesenchymal Stem Cells both in vivo and in vitro |
| Investigator(s): | Chan GCF |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Providence Foundation Limited |
| Start Date: | 01/2017 |
| List of Research Outputs |
| Cheuk K.L.D., Chiang A.K.S., Chan G.C.F. and Ha S.Y., Urate oxidase for the prevention and treatment of tumour lysis syndrome in children with cancer, In: The Cochrane Collaboration, Cochrane Database of Systematic Reviews: Reviews. Chichester, UK, John Wiley & Sons, Ltd, 2017. |
| Ho K.Y., Li W.H.C., LAM K.W.K., Chan G.C.F. and Chiu S.Y., ICCN 2016 Abstract Book - OE-26 Effectiveness of Adventure-Based Training in Reducing Fatigue Among Childhood Cancer Survivors , Cancer Nursing. 2016, 39: S1-S121. |
| Kwok J.S.Y., GUO M., Yang W., Lee C.K., Chan N.K., Ho J., Tang W.H., Chan Y.S., Middleton D., Lu L. and Chan G.C.F., HLA-A, -B and -DRB1 genotyping and haplotype frequencies of 3892 cord blood units in the Hong Kong Chinese Cord Blood Registry, Human Immunology. 2016, 77: 1109-1110. |
| Kwok J.S.Y., GUO M., Yang W., Lee C.K., Ho J., Tang W.H., Chan Y.S., Middleton D., Lu L. and Chan G.C.F., HLA-A, -B, -C, and -DRB1 genotyping and haplotype frequencies for a Hong Kong Chinese population of 7595 individuals, Human Immunology. ELSEVIER, 2016, 77: 1111-1112. |
| LAM K.W.K., Li W.H.C., Ho K.Y., Chung O.K.J. and Chan G.C.F., Factors contributing to the low physical activity level for Hong Kong Chinese children hospitalised with cancer: an exploratory study, Journal of Clinical Nursing. 2017, 26: 190-201. |
| Law H.Y., Yang L.H., Lau A.S.Y. and Chan G.C.F., Mechanism of action and molecular identification of individual bio-active constituents from an effective traditional Chinese medicine decoction in treating influenza virus infection. Submitted to Journal of Antimicrobial Chemotherapy, 2016. |
| Li W.H.C., Ho K.Y., Chung O.K.J., Lam H.S., Chiu S.Y. and Chan G.C.F., Adventure-based training to promote physical activity, reduce fatigue, and enhance quality of life among Hong Kong Chinese childhood cancer survivors: A phase 3 randomised controlled trial (poster and abstract), Health Research Symposium 2017, June 16, 2017, Hong Kong. 2017. |
| Liu A.P.Y., Leung Y.Y., Kwok J.S.Y., Chiang A.K.S., Ha S.Y., Lee P.P.W., Cheuk D.K.L. and Chan G.C.F., HAPLOIDENTICAL HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR RELAPSED/REFRACTORY OR METASTATIC PEDIATRIC SOLID TUMORS, SIOP Asia 2017. |
| Ning B.T., Yu B., Chan S., Chan J.L., Huang J. and Chan G.C.F., Treatment of Neuroblastoma with an Engineered “Obligate” Anaerobic Salmonella typhimurium Strain YB1, Journal of Cancer. 2017, 8(9): 1609–1618. |
| See W.S.Q., Cheuk K.L.D., To K.F., Ip P.C.P., Chiang A.K.S., Ha S.Y. and Chan G.C.F., Congenital intestinal fibrosarcoma with rapid recurrence requiring adjuvant chemotherapy, Pediatrics International. 2017. |
| See W.S.Q., Chang K.O., Cheuk K.L.D., Leung Y.R., Chan G.C.F., Chan S.C. and Ha S.Y., Inhibitor development after liver transplantation in congenital factor VII deficiency, Haemophilia. 2016, 22(5): e417-422. |
| TANG H.L., YEUNG P., Chan G.C.F., Chan B.P., Wong K.K.Y. and Tsia K.K.M., Time-stretch microscopy on a DVD for high-throughput imaging cell-based assay, Biomedical Optics Express. 2017, 8: 640. |
| TSANG H.Y., LEUNG K.C., MAK C.C.Y., Miu X., Lee S.L., Chan G.C.F., Yung A.W.Y. and Chung B.H.Y., Genetic diagnosis of drug-resistant epilepsy by whole exome sequencing and chromosomal array in Hong Kong, Hong Kong College of Paediatricians, 4th Annual Scientific Meeting cum 5th Hong Kong-Guangdong-Shanghai-Chongqing Paediatric Exchange Meeting, HK, 3-4 December 2016. |
| TSANG H.Y., LEUNG K.C., MAK C.C.Y., Chu W.Y., Mu X., Lee S.L., Chan G.C.F., Yung A.W.Y. and Chung B.H.Y., Genetic diagnosis of early onset epilepsy by whole exome sequencing and chromosomal array in Hong Kong, Asian Society for Pediatric Research (ASPR) and Faculty of Medicine Ramathibodi Hospital 2016, Thailand, Bangkok, 10-12 November 2016. |
| Tso W.Y.W., YEUNG K.S., Ip J.K.J., Liu A.P.Y., Lee P.P.W., Chu W.Y., Chong C.Y., Ho M.H.K., Chan G.C.F., Lau Y.L. and Chung B.H.Y., The genetics of macrocephaly, autistic spectrum disorders and developmental delay in Chinese children. British Paediatric Neurology Association Annual Meeting, 11-13 January 2017, UK [Poster Presentations], Developmental Medicine & Child Neurology. 2017, 59: 19-108. |
| WANG R., Chan S., Chan G.C.F., Li H. and Sun H., Bismuth Compounds as Novel Antagonists Against Toxicity of Cisplatin, 8th Asian Biological Inorganic Chemistry Conference. 2016. |
| YEUNG K.S., Ip J.K.J., Chow C.P., Kuong E.E.Y.L., Tam P.K.H., Chan G.C.F. and Chung B.H.Y., Somatic PIK3CA mutations in seven patients with PIK3CA-related overgrowth spectrum, American Journal of Medical Genetics Part A. 2017, 173A: 978-984. |
| Researcher : Chan HSS |
| Project Title: | Comprehensive mutation analysis for childhood onset neuromuscular disorder in Chinese patients using Next Generation Sequencing panels |
| Investigator(s): | Chan HSS, Chung BHY, Lee HHC, Wong CNV |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 08/2016 |
| List of Research Outputs |
| Chan H.S.S., Ho S.L.R., Chan A., Ip J., Wong S., Ng G., Lee H., Cheng S., Liu K.T., Lee C.N., Fung S., Cherk S., Chan T., Lam W., Shek T. and Wong C.N.V., Best Free Paper Award on the study ' Congenital myopathies are a group of phenotypically and genetically heterogeneous diseases', 29th Annual Scientific Meeting of the Hong Kong Neurological Society on 5th November 2016. 2016. |
| Chan H.S.S., Fung C.W. and Chung B.H.Y., Improving genetic diagnosis by whole exome sequencing in rare hereditary peripheral neuropathies, Hong Kong College of Paediatricians 4th Annual Scientific Meeting cum 5th HK Guangdong Shanghai Chongquing Paediatric Exchange Meeting. 2016. |
| Chan H.S.S., Chan O.K. and Engel A.G., Long term follow-up of three children with COLQ-related congenital Myasthenic syndrome of different mutations responsive to salbutamol, Hong Kong College of Paediatricians 4th Annual Scientific Meeting cum 5th HK Guangdong Shanghai Chongquing Paediatric Exchange Meeting. 2016. |
| Chan H.S.S., Neuromuscular Disorder: Are we doing better in diagnosis? The 29th Annual Scientific Meeting of the Hong Kong Neurological Society: Neuromuscular Disorder Symposium. Hong Kong 5-6 Nov 2016, 2016. |
| Donkervoort S., Chan H.S.S., Hayes L.H., Bradley N., Nguyen D., Leach M.E., Mohassel P., Hu Y., Thangarajh M., Bharucha-Goebel D., Kan A., Ho R.S.L., Reyes C.A., Nance J., Moore S.A., Foley A.R. and Bonnemann C.G., Cytoplasmic body pathology in severe ACTA1-related myopathy in the absence of typical nemaline rods., neuromuscul disord. 2017, 27(6): 531-536. |
| Fu K.W., Ho F.K.W., Rao N., Fan F.J., Li L., Lee T.M.C., Chan H.S.S., Yung A.W.Y., Young Y.M.E. and Ip P., Parental restriction reduces the harmful effects of in-bedroom electronic devices, Archives of Disease in Childhood. 2017, archdischild-2017-312639. |
| Researcher : Chan KW |
| List of Research Outputs |
| Ben-Ali M., Yang J., Chan K.W., Ben-Mustapha I., Yang W., Lau Y.L. and Barbouche M.R., Homozygous transcription factor 3 gene (TCF3) mutation is associated with severe hypogammaglobulinemia and B-cell acute lymphoblastic leukemia., J Allergy Clin Immunol.. 2017, S0091-6749(17)30794-7. |
| Researcher : Chan S |
| List of Research Outputs |
| Ning B.T., Yu B., Chan S., Chan J.L., Huang J. and Chan G.C.F., Treatment of Neuroblastoma with an Engineered “Obligate” Anaerobic Salmonella typhimurium Strain YB1, Journal of Cancer. 2017, 8(9): 1609–1618. |
| WANG R., Chan S., Chan G.C.F., Li H. and Sun H., Bismuth Compounds as Novel Antagonists Against Toxicity of Cisplatin, 8th Asian Biological Inorganic Chemistry Conference. 2016. |
| Researcher : Chan SHS |
| Project Title: | Comprehensive mutation analysis for childhood onset neuromuscular disorder in Chinese patients using Next Generation Sequencing panels |
| Investigator(s): | Chan HSS, Chung BHY, Lee HHC, Wong CNV |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 08/2016 |
| List of Research Outputs |
| Researcher : Chan SY |
| Project Title: | Role of TSPYL2 in epigenetic control of gene expression |
| Investigator(s): | Chan SY, Chan KMJ |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2014 |
| Project Title: | Multiplex gene targeting of TSPYL family in embryonic stem cells |
| Investigator(s): | Chan SY |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2015 |
| Project Title: | TSPYL1 and TSPYL4: Novel tumour suppressors? |
| Investigator(s): | Chan SY, Ching YP |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2017 |
| List of Research Outputs |
| CHONG C.H., NG C.P., Mak H.S., Li Q., McAlonan G.M. and Chan S.Y., LRRC7 regulates neurite morphogenesis through mGluR5, Annual Meeting of Neuroscience 2016 (San Diego, USA). 2016. |
| Chan S.Y., Facilitator, Workshop on Animal Research Ethics, 2016, 2016. |
| Chan S.Y., Facilitator, Workshop on Animal Research Ethics, 2017, 2017. |
| Researcher : Chau AKT |
| List of Research Outputs |
| MAK C.C.Y., Chow P.C., Liu A.P.Y., Chan Y.K., Chu W.Y., Mok T.K.G., LEUNG K.C., YEUNG K.S., Chau A.K.T., Lowther C., Scherer S.W., Marshall C.R., Bassett A.S. and Chung B.H.Y., De novo large rare copy-number variations contribute to conotruncal heart disease in Chinese patients, npj Genomic Medicine. 2016, 1: 16033. |
| Researcher : Chau SKC |
| List of Research Outputs |
| Chau S.K.C., Yung A.W.Y. and Lee S.L., Long-Term Management for Ventilator-Assisted Children in Hong Kong: 2 Decades' Experience, Respiratory Care. 2017, 62: 54-64. |
| LEUNG K.C., Ying D., MAK C.C.Y., Chen X.Y., Xu W., YEUNG K.S., Wong W.L., Chu W.Y., Mok T.K.G., Chau S.K.C., McLuskey J., Ong W.P.T., Leong H.Y., Chan Y.K., Yang W., Chen J.H., Li A.M., Sham P.C., Lau Y.L., Chung B.H.Y. and Lee S.L., CFTR founder mutation causes protein trafficking defects in Chinese patients with cystic fibrosis , Molecular Genetics & Genomic Medicine. 2016. |
| LEUNG K.C., Ying D., MAK C.C.Y., Chen X.Y., Xu W., YEUNG K.S., Chu W.Y., Mok T.K.G., Chau S.K.C., McLuskey J., Ong W.P.T., Leong H.Y., Chan Y.K., Yang W., Chen J.H., Li A.M., Lau Y.L., Lee S.L. and Chung B.H.Y., Identification of a CFTR founder mutations, c.3068T>G:p.I1023R, which causes protein trafficking defects in Chinese patients with cystic fibrosis, Asian Society for Pediatric Research (ASPR) and Faculty of Medicine Ramathibodi Hospital 2016, Thailand, Bangkok, 10-12 November 2016. |
| Researcher : Cheuk DKL |
| Project Title: | Renal dysfunction in patients with transfusion-dependent thalassaemia (REDEFINE study) |
| Investigator(s): | Cheuk KLD |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Children's Thalassaemia Foundation - General Awards |
| Start Date: | 10/2016 |
| List of Research Outputs |
| Researcher : Cheuk KLD |
| Project Title: | Renal dysfunction in patients with transfusion-dependent thalassaemia (REDEFINE study) |
| Investigator(s): | Cheuk KLD |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Children's Thalassaemia Foundation - General Awards |
| Start Date: | 10/2016 |
| List of Research Outputs |
| Cheuk K.L.D., Sieswerda E., van Dalen E.C., Postma A. and Kremer L.C., Medical interventions for treating anthracycline-induced symptomatic and asymptomatic cardiotoxicity during and after treatment for childhood cancer, In: The Cochrane Collaboration, Cochrane Database of Systematic Reviews: Reviews. Chichester, UK, John Wiley & Sons, Ltd, 2016. |
| Cheuk K.L.D., Chiang A.K.S., Chan G.C.F. and Ha S.Y., Urate oxidase for the prevention and treatment of tumour lysis syndrome in children with cancer, In: The Cochrane Collaboration, Cochrane Database of Systematic Reviews: Reviews. Chichester, UK, John Wiley & Sons, Ltd, 2017. |
| See W.S.Q., Cheuk K.L.D., To K.F., Ip P.C.P., Chiang A.K.S., Ha S.Y. and Chan G.C.F., Congenital intestinal fibrosarcoma with rapid recurrence requiring adjuvant chemotherapy, Pediatrics International. 2017. |
| See W.S.Q., Chang K.O., Cheuk K.L.D., Leung Y.R., Chan G.C.F., Chan S.C. and Ha S.Y., Inhibitor development after liver transplantation in congenital factor VII deficiency, Haemophilia. 2016, 22(5): e417-422. |
| Researcher : Cheung PT |
| Project Title: | The Endocrine Society 83rd Annual Meeting Mutations of the CYP11B2 Gene in a Patient with Corticosterone Methyl Oxidase Type II Deficiency |
| Investigator(s): | Cheung PT |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2001 |
| Project Title: | International Perinatal Collegium 2005 Meeting New Approaches in Old Models - Identification of Novel Molecular Alterations in Neonatal Mouse Hypoxic-Ischaemic Brain Damage |
| Investigator(s): | Cheung PT |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2005 |
| Project Title: | 4th Asian Epigenomics Meeting Methyl mercury induced epigenetic dysregulation of BDNF gene in NG108 cells in vitro – a possible mechanism of environment-epigenome interactions underlying neuropsychiatric and neurodevelopmental disorders. |
| Investigator(s): | Cheung PT |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2009 |
| Project Title: | 9th Joint Meeting of Paediatric Endocrinology; Effective treatment with low dose dihydrotestosterone gel on three Chinese boys with 5-alpha-reductase II deficiency |
| Investigator(s): | Cheung PT |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2013 |
| List of Research Outputs |
| Man E., Cheung P.T. and Cheung Y.F., Associations between arterial structure and function and serum levels of liver enzymes in obese adolescents, J Paediatr Child Health 2017. 2017. |
| Researcher : Cheung YF |
| Project Title: | CSX/NKX2.5 mutations in patients with pulmonary atresia and intact ventricular septum |
| Investigator(s): | Cheung YF, Chan SY |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2003 |
| Project Title: | Development of a multimedia tool for teaching of paediatric cardiology |
| Investigator(s): | Cheung YF |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Run Run Shaw Research and Teaching Endowment Fund - Teaching Grants |
| Start Date: | 04/2004 |
| Project Title: | Circulating MicroRNAs and Myocardial Damage in Paediatric Cancer Patients Receiving Anthracyline Therapy |
| Investigator(s): | Cheung YF, Cheuk KLD, Chan GCF |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2014 |
| Completion Date: | 07/2017 |
| Project Title: | Left Atrial Mechanics and Remodeling in Anthracycline-Treated Long-Term Survivors of Childhood Cancers |
| Investigator(s): | Cheung YF |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 04/2015 |
| Completion Date: | 09/2016 |
| Project Title: | Circulating Transforming Growth Factor-β and Aortic Dilation in Patients with Repaired Congenital Heart Disease |
| Investigator(s): | Cheung YF |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 05/2015 |
| Project Title: | Right and Left Atrial Function in Patients with Thalassaemia Major: Interaction with Ventricular Diastolic Function and Arterial Mechanics (Project No. 2015/07) |
| Investigator(s): | Cheung YF |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Children's Thalassaemia Foundation - General Awards |
| Start Date: | 11/2015 |
| Project Title: | Multi-modality evaluation of cardiac function in children late after cancer therapy: the emerging field of paediatric cardio-oncology |
| Investigator(s): | Cheung YF |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Children's Cancer Foundation - General Award |
| Start Date: | 01/2016 |
| Project Title: | Novel MRI T1 mapping for estimation of T1 relaxation time of myocardium in patients with beta-thalassaemia major |
| Investigator(s): | Cheung YF, See WSQ, Chan GCF |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Children's Thalassaemia Foundation - General Awards |
| Start Date: | 01/2017 |
| List of Research Outputs |
| Cheung Y.F., Acute collapse – acquired cardiovascular causes apart from arrhythmia, The 8th Annual General Meeting & Annual Scientific Meeting, Hong Kong Society of Paediatric Cradiology, Hong Kong. 2016. |
| Cheung Y.F., Advances on Management of Congenital Heart Disases in Children, Professional CME Series on Child Health 2016, The Hong Kong Paediatric Foundation, Hong Kong. 2016. |
| Cheung Y.F., Cardiac Dysfunction Late After Paediatric Catheter Intervention, The 19th South China International Congress of Cardiology, Guangzhou. 2017. |
| Cheung Y.F., Chief-Editor, Hong Kong Journal of Paediatrics (new series), Editorial Board , 2017. |
| Cheung Y.F., Clinical Approach to Heart Murmur in Children, Common Cardiovascular Problems in Children and Adolescents, The Department of Health Student Health Service (SHS) & The Hong Kong Paediatric Society (HKPS), Hong Kong. 2017. |
| Cheung Y.F., Echocardiographic Assessment of Myocardial Strain: Applications in Paediatric Congenital and Acquired Heart Diseases, 2016 GE Cardiac Ultrasound MAB and Mega Conference of Cardiologist, Chengdu. 2016. |
| Cheung Y.F., Echocardiographic Evaluation of Right Ventricular Function Before and After Pulmonary Valve Implantation, 25th Annual Scientific Congress of Hong Kong College of Cardiology, Hong Kong. 2017. |
| Cheung Y.F., Functional assessment of the right ventricle in pulmonary hypertension, The 6th Congress of Asia-Pacific Pediatric Cardiac Society, Shanghai. 2016. |
| Cheung Y.F., Kawasaki Disease: Diagnosis and Management, 第一屆錢江小兒心血管 疾病診治高峰論壇暨 2016年小兒心血管疾病 診治新進展國家級繼續 教育學習班及2016年中 國先天性心臟病診治巡 講, Hangzhou, Zhejiang, 2016. |
| Cheung Y.F., Long-term Management of Kawasaki Disease, 2016年第二屆西部兒童 心血管協作網高峰論 壇、兒童心血管疾病進 展培訓班、胎兒期心血 管疾病診斷及治療進展 培訓班, Chengdu, Sichuan, 2016. |
| Cheung Y.F., Medical Humanities in Paediatric Clinical Practice, Hong Kong Journal of Paediatrics (New Series). 2017. |
| Cheung Y.F., Monitoring and Managing Chemotherapy-Related Cardiotoxicity in Long-term Survivors of Childhood Cancers , The 27th Great Wall International Congress of Cardiology, Beijing. 2016. |
| Cheung Y.F., Right Heart Function in Congenital Heart Disease, 2016年第二屆西部兒童 心血管協作網高峰論 壇、兒童心血管疾病進 展培訓班、胎兒期心血 管疾病診斷及治療進展 培訓班, Chengdu, Sichuan, 2016. |
| Cheung Y.F., Strain Imaging in Congenital and Paediatric Heart Diseases, The 6th Congress of Asia-Pacific Pediatric Cardiac Society, Shanghai. 2016. |
| Cheung Y.F., Understanding the Genetics of Kawasaki Disease: Toward Precision Medicine , The 6th Congress of Asia-Pacific Pediatric Cardiac Society, Shanghai . 2016. |
| Cheung Y.F., Vascular Dysfunction of Kawasaki Disease, The 1st International Pediatric Precision Medicine Forum, Shanghai. 2016. |
| Man E., Cheung P.T. and Cheung Y.F., Associations between arterial structure and function and serum levels of liver enzymes in obese adolescents, J Paediatr Child Health 2017. 2017. |
| Yu C.K., Wong W.H., LI W.Y.V. and Cheung Y.F., Left ventricular stiffness in adolescents and young adults with repaired tetralogy of Fallot., Scientific Reports. 2017, 7: 1252. |
| Researcher : Chiang AKS |
| Project Title: | Genetic studies of tubercubosis |
| Investigator(s): | Chiang AKS |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Other Funding Scheme |
| Start Date: | 03/2002 |
| Project Title: | Prospective study of virologic and immunologic parameters of primary Epstein-Barr virus infection in Chinese children |
| Investigator(s): | Chiang AKS, Chan KH |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2003 |
| Project Title: | Prospective study of Epstein-Barr virus (EBV) strains in primary EBV infection |
| Investigator(s): | Chiang AKS |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2004 |
| Project Title: | Longitudinal study of Epstein-Barr virus specific antibody responses in childhood infectious mononucleosis |
| Investigator(s): | Chiang AKS |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 12/2005 |
| Project Title: | Delineating pathogenic mutations in Epstein-Barr virus genomes of nasopharyngeal carcinoma using next generation sequencing technology |
| Investigator(s): | Chiang AKS, Lung ML, Sham PC, Yang W, Kwong DLW |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2015 |
| Project Title: | Longitudinal study of NK cell subset and function in childhood infectious mononucleosis and post-transplant lymphoproliferative disorder |
| Investigator(s): | Chiang AKS |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2015 |
| Completion Date: | 03/2017 |
| Project Title: | 17th International Symposium on EBV and associated diseases; Deficiency in production of early differentiated NK cells with accumulation of terminally differentiated NK cells in post-transplant lymphoproliferative disorders/Target capture and sequencing of Epstein-Barr virus genomes using DNA oligo probes |
| Investigator(s): | Chiang AKS |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2016 |
| Completion Date: | 08/2016 |
| Project Title: | Mechanism of cell death by inhibition of histone deacetylation and proteasome degradation pathways in Burkitt lymphoma and lymphoblastoid cells |
| Investigator(s): | Chiang AKS, Hui KF |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2017 |
| Project Title: | Reactivation of Epstein-Barr virus (EBV) lytic cycle in EBV-associated epithelial malignancies by iron chelators and evaluation of its therapeutic potential |
| Investigator(s): | Chiang AKS, Hui KF, Yang D |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 05/2017 |
| List of Research Outputs |
| Cheuk K.L.D., Chiang A.K.S., Chan G.C.F. and Ha S.Y., Urate oxidase for the prevention and treatment of tumour lysis syndrome in children with cancer, In: The Cochrane Collaboration, Cochrane Database of Systematic Reviews: Reviews. Chichester, UK, John Wiley & Sons, Ltd, 2017. |
| Chiang A.K.S., Deficiency in production of early differentiated NK cells with accumulation of terminally differentiated NK cells in post-transplant lymphoproliferative disorders (abstract), 17th Symposium on Epstein Barr Virus and Associated Disease, Zurich, Switzerland. 2016. |
| Chiang A.K.S., Translating Knowledge to Treatment of Paediatric non-Hodgkin Lymphoma, 第二屆兒童淋巴瘤學術研討會暨2016年中國抗淋巴瘤聯盟兒童淋巴瘤巡講, Guangzhou, China. 2016. |
| Hui K.F., YEUNG P.L. and Chiang A.K.S., Targeting the survival function of ebna-3c protein in ebv-positive burkitt and lymphoblastoid cells by histone deacetylase and proteasome inhibitors, 17th Symposium on Epstein Barr Virus and Associated Disease, Zurich, Switzerland. 2016. |
| Liu A.P.Y., Leung Y.Y., Kwok J.S.Y., Chiang A.K.S., Ha S.Y., Lee P.P.W., Cheuk D.K.L. and Chan G.C.F., HAPLOIDENTICAL HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR RELAPSED/REFRACTORY OR METASTATIC PEDIATRIC SOLID TUMORS, SIOP Asia 2017. |
| Liu A.P.Y., Ip J.J.K., Leung A.W.K., Luk C.W., Li C.H., Ho K.K.H., Lo C.L.R., Chan E.K.W., Chan A.C.Y., Chung H.Y. and Chiang A.K.S., Outcome of Paediatric Hepatoblastoma in Hong Kong, SIOPEL Spring Meeting 2017. |
| Lung M.L., Dai W., ZHENG H., Ko J.M.Y., Sham P.C., Yang W., Cherny S.S., Ngan R.K.C., Kwong D.L.W., Ng W.T., Chiang A.K.S. and Lee W.M.A., Elucidating the Genetic Basis for Early-age Onset Nasopharyngeal Carcinoma in Hong Kong, Health Research Symposium 2017, Hong Kong. June 16, 2017.. 2017. |
| See W.S.Q., Cheuk K.L.D., To K.F., Ip P.C.P., Chiang A.K.S., Ha S.Y. and Chan G.C.F., Congenital intestinal fibrosarcoma with rapid recurrence requiring adjuvant chemotherapy, Pediatrics International. 2017. |
| Researcher : Chik SCC |
| List of Research Outputs |
| Lau A.S.Y., Yang L.H., Chik S.C.C., Law H.Y. and Lee D.C.W., Coriolus Versicolor Extracts, Methods of Preparation and Uses Thereof. Japanese patent No. 5959523., 2016. |
| Researcher : Chiu SSS |
| Project Title: | Streptococcus pneumoniae carriage in young children in Hong Kong |
| Investigator(s): | Chiu SSS, Ho PL |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Health Services Research Fund - Full Grants |
| Start Date: | 10/1999 |
| Project Title: | Impact of universal vaccination with the 7-valent conjugate pneumocccal vaccine (PCV7) in Hong Kong on the incidence of pneumonia hospitalization and carriage in children |
| Investigator(s): | Chiu SSS, Ho PL |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Centre for Health Protection |
| Start Date: | 07/2010 |
| Project Title: | A prospective longitudinal study to correlate maternal antibodies against influenza A and B with influenza infection and hospitalization in the first 6 months of life |
| Investigator(s): | Chiu SSS, Cowling BJ, Peiris JSM |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2014 |
| Researcher : Chiu TA |
| List of Research Outputs |
| Chiu T.A., LEUNG K.C., Chu W.Y., Gripp K.W. and Chung B.H.Y., A novel patient with an attenuated Costello syndrome phenotype due to an HRAS mutation affecting codon 146-Literature review and update , American Journal of Medical Genetics Part A. 2017, 173: 1109-1114. |
| Chiu T.A., Zhu L., Mok T.K.G., LEUNG K.C., Chow C.B. and Chung B.H.Y., Before and after – Nutritional transformation of dysmorphism in a case of Costello syndrome, European Journal of Medical Genetics. 2016, 59: 573-576. |
| Chiu T.A., Chu W.Y., Kan S.Y.A. and Chung B.H.Y., What is the Diagnosis?, Hong Kong Journal of Paediatrics (new series). Medcom Limited, 2016, 21(4): 298,311-314. |
| Chu W.Y., LEUNG K.C., Mak A.S.L., Chiu T.A., MAK C.C.Y., Mok T.K.G., Tang W.F., Chan Y.K., Tang M.H.Y., Lau E.T.K., So K.W., Tao Q.V., Fung C.W., Wong V.C.N., Lee S.L., Marshall C., Scherer S., Kan S.Y.A. and Chung B.H.Y., Use of clinical chromosomal microarray in Hong Kong Chinese patients with autism spectrum disorder - Implication of a copy number variation involving DPP10, Asian Society for Pediatric Research (ASPR) and Faculty of Medicine Ramathibodi Hospital 2016, Thailand, Bangkok, 10-12 November 2016. |
| Chung B.H.Y., Mak S.L., Chiu T.A., LEUNG K.C., MAK C.C.Y., Chu W.Y., Mok T.K.G., Chan Y.K., Kan S.Y.A., Tang M.H.Y., Lau E.T.K., Fung C.W. and Lee S.L., Use of chromosomal microarray in Hong Kong patients with autism spectrum disorder - implication of a copy number variation involving DPP10, ASHG 2016, Vancouver, Canada, 18-22 October 2016. |
| Researcher : Chong CY |
| List of Research Outputs |
| Tso W.Y.W., YEUNG K.S., Ip J.K.J., Liu A.P.Y., Lee P.P.W., Chu W.Y., Chong C.Y., Ho M.H.K., Chan G.C.F., Lau Y.L. and Chung B.H.Y., The genetics of macrocephaly, autistic spectrum disorders and developmental delay in Chinese children. British Paediatric Neurology Association Annual Meeting, 11-13 January 2017, UK [Poster Presentations], Developmental Medicine & Child Neurology. 2017, 59: 19-108. |
| Researcher : Chow CB |
| Project Title: | A geographical study of child injury in Hong Kong: Spatial variation among 18 districts |
| Investigator(s): | Chow CB, Ip P, Wong WHS |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Health Care and Promotion Fund - Research Grant Projects |
| Start Date: | 09/2013 |
| Completion Date: | 12/2016 |
| Project Title: | Measuring the burden of fatal and nonfatal injury in Hong Kong |
| Investigator(s): | Chow CB, Ip P, McGhee S, Tsui MSH, Kam CW, Chan EW, Wong WHS, Chiu IWS |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2014 |
| Project Title: | Measuring the practicability and effectiveness of online-based injury prevention anticipatory guidance |
| Investigator(s): | Chow CB, Ip P, Wong WHS, Tang MHY |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Health Care and Promotion Fund - Research Grant Projects |
| Start Date: | 07/2016 |
| Project Title: | Developing indicators to monitor injury trend and burden in Hong Kong |
| Investigator(s): | Chow CB, Ip P, Wong WHS |
| Department: | The University of Hong Kong |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 08/2016 |
| List of Research Outputs |
| Chiu T.A., Zhu L., Mok T.K.G., LEUNG K.C., Chow C.B. and Chung B.H.Y., Before and after – Nutritional transformation of dysmorphism in a case of Costello syndrome, European Journal of Medical Genetics. 2016, 59: 573-576. |
| Researcher : Chow PC |
| List of Research Outputs |
| MAK C.C.Y., Chow P.C., Liu A.P.Y., Chan Y.K., Chu W.Y., Mok T.K.G., LEUNG K.C., YEUNG K.S., Chau A.K.T., Lowther C., Scherer S.W., Marshall C.R., Bassett A.S. and Chung B.H.Y., De novo large rare copy-number variations contribute to conotruncal heart disease in Chinese patients, npj Genomic Medicine. 2016, 1: 16033. |
| Researcher : Chu WY |
| List of Research Outputs |
| Chiu T.A., LEUNG K.C., Chu W.Y., Gripp K.W. and Chung B.H.Y., A novel patient with an attenuated Costello syndrome phenotype due to an HRAS mutation affecting codon 146-Literature review and update , American Journal of Medical Genetics Part A. 2017, 173: 1109-1114. |
| Chiu T.A., Chu W.Y., Kan S.Y.A. and Chung B.H.Y., What is the Diagnosis?, Hong Kong Journal of Paediatrics (new series). Medcom Limited, 2016, 21(4): 298,311-314. |
| Chu W.Y., Chu S.P.W., Mok W.K.Y., Tan T.Y. and Chung B.H.Y., Insights on sensitive language use in the Hong Kong healthcare setting: perceptions of parents and caregivers of patients with Down syndrome, Hong Kong Journal of Paediatrics. 2017, 22: 26-33. |
| Chu W.Y., LEUNG K.C., Mak A.S.L., Chiu T.A., MAK C.C.Y., Mok T.K.G., Tang W.F., Chan Y.K., Tang M.H.Y., Lau E.T.K., So K.W., Tao Q.V., Fung C.W., Wong V.C.N., Lee S.L., Marshall C., Scherer S., Kan S.Y.A. and Chung B.H.Y., Use of clinical chromosomal microarray in Hong Kong Chinese patients with autism spectrum disorder - Implication of a copy number variation involving DPP10, Asian Society for Pediatric Research (ASPR) and Faculty of Medicine Ramathibodi Hospital 2016, Thailand, Bangkok, 10-12 November 2016. |
| Chung B.H.Y., YEUNG K.S., Tso W.Y.W., Ying D., Ip J.K.J., Chu W.Y., LEUNG K.C. and MAK C.C.Y., Exome sequencing of a Chinese patient cohort with ID/ASD and macrocephaly/megalencephaly: Identification of a patient with biallelic PTEN mutations and others with germline/ post-zygotic mutations in PIK3C-AKT-mTOR pathway, 17th Manchester Dysmorphology Conference, Manchester, UK, 7-10 November 2016. |
| Chung B.H.Y., Mak S.L., Chiu T.A., LEUNG K.C., MAK C.C.Y., Chu W.Y., Mok T.K.G., Chan Y.K., Kan S.Y.A., Tang M.H.Y., Lau E.T.K., Fung C.W. and Lee S.L., Use of chromosomal microarray in Hong Kong patients with autism spectrum disorder - implication of a copy number variation involving DPP10, ASHG 2016, Vancouver, Canada, 18-22 October 2016. |
| LEUNG K.C., Ying D., MAK C.C.Y., Chen X.Y., Xu W., YEUNG K.S., Wong W.L., Chu W.Y., Mok T.K.G., Chau S.K.C., McLuskey J., Ong W.P.T., Leong H.Y., Chan Y.K., Yang W., Chen J.H., Li A.M., Sham P.C., Lau Y.L., Chung B.H.Y. and Lee S.L., CFTR founder mutation causes protein trafficking defects in Chinese patients with cystic fibrosis , Molecular Genetics & Genomic Medicine. 2016. |
| LEUNG K.C., Ying D., MAK C.C.Y., Chen X.Y., Xu W., YEUNG K.S., Chu W.Y., Mok T.K.G., Chau S.K.C., McLuskey J., Ong W.P.T., Leong H.Y., Chan Y.K., Yang W., Chen J.H., Li A.M., Lau Y.L., Lee S.L. and Chung B.H.Y., Identification of a CFTR founder mutations, c.3068T>G:p.I1023R, which causes protein trafficking defects in Chinese patients with cystic fibrosis, Asian Society for Pediatric Research (ASPR) and Faculty of Medicine Ramathibodi Hospital 2016, Thailand, Bangkok, 10-12 November 2016. |
| LEUNG K.C., Ying D., Shek N.W.M., Chu W.Y., YEUNG K.S., Tang M.H.Y., Kan S.Y.A., Chan Y.K., Ip J.K.J., Yang W., Lau Y.L. and Chung B.H.Y., Identification of a novel homozygous missense mutation in ABR causing cerebellar hypoplasia with early lethality, Asian Society for Pediatric Research (ASPR) and Faculty of Medicine Ramathibodi Hospital 2016, Thailand, Bangkok, 10-12 November 2016. |
| MAK C.C.Y., Chow P.C., Liu A.P.Y., Chan Y.K., Chu W.Y., Mok T.K.G., LEUNG K.C., YEUNG K.S., Chau A.K.T., Lowther C., Scherer S.W., Marshall C.R., Bassett A.S. and Chung B.H.Y., De novo large rare copy-number variations contribute to conotruncal heart disease in Chinese patients, npj Genomic Medicine. 2016, 1: 16033. |
| Mok T.K.G., Chu W.Y., Luk H.M. and Chung B.H.Y., Computer-aided facial recognition of Chinese individuals with Angelman syndrome in Hong Kong, Hong Kong College of Paediatricians, 4th Annual Scientific Meeting cum 5th Hong Kong-Guangdong-Shanghai-Chongqing Paediatric Exchange Meeting, HK, 3-4 December 2016. |
| Panagiotou E.S., Sanjurjo Soriano C., Poulter J.A., Lord E.C., Dzulova D., Kondo H., Hiyoshi A., Chung B.H.Y., Chu W.Y., Lai C.H.Y., Tafoya M.E., Karjosukarso D., Collin R.W.J., Topping J., Downey L.M., Ali M., Ingleheam C.F. and Toomes C., Defects in the Cell Signaling Mediator β-Catenin Cause the Retinal Vascular Condition FEVR, The American Journal of Human Genetics. 2017, 100: 960-968. |
| TSANG H.Y., LEUNG K.C., MAK C.C.Y., Chu W.Y., Mu X., Lee S.L., Chan G.C.F., Yung A.W.Y. and Chung B.H.Y., Genetic diagnosis of early onset epilepsy by whole exome sequencing and chromosomal array in Hong Kong, Asian Society for Pediatric Research (ASPR) and Faculty of Medicine Ramathibodi Hospital 2016, Thailand, Bangkok, 10-12 November 2016. |
| Tso W.Y.W., YEUNG K.S., Ip J.K.J., Liu A.P.Y., Lee P.P.W., Chu W.Y., Chong C.Y., Ho M.H.K., Chan G.C.F., Lau Y.L. and Chung B.H.Y., The genetics of macrocephaly, autistic spectrum disorders and developmental delay in Chinese children. British Paediatric Neurology Association Annual Meeting, 11-13 January 2017, UK [Poster Presentations], Developmental Medicine & Child Neurology. 2017, 59: 19-108. |
| Researcher : Chung BHY |
| Project Title: | Provision of molecular diagnosis for patients with birth defects/genetic conditions in Hong Kong |
| Investigator(s): | Chung BHY, Lau YL, Yang W |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 02/2012 |
| Project Title: | Comprehensive genetic evaluation of children with autism spectrum disorders in Hong Kong |
| Investigator(s): | Chung BHY, Wong CNV, Lee SL, Fung CW |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 08/2012 |
| Project Title: | Copy-number variations in Chinese patients with conotruncal defects - a pilot study of 100 patients |
| Investigator(s): | Chung BHY, Liu APY |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Children's Heart Foundation - General Award |
| Start Date: | 03/2013 |
| Project Title: | Genomic Medicine for All - State of Art Testing for Hong Kong Children with Genetic Conditions |
| Investigator(s): | Chung BHY, Lau YL, Yang W, Sham PC, Chan YK |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 01/2014 |
| Project Title: | Cell lineage-specific differential DNA methylation in Chinese patients with early-onset systemic lupus erythematosus: implications for disease susceptibility |
| Investigator(s): | Chung BHY, Lau YL, Yang W, Lee PPW |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Completion Date: | 01/2018 |
| Project Title: | Identifying the causality of a novel variant – A candidate mutation leading to cerebellar hypoplasia |
| Investigator(s): | Chung BHY, Ying D |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2015 |
| Completion Date: | 12/2016 |
| Project Title: | Identifying the genetic causes underlying prenatally-diagnosed structural congenital anomalies (SCAs) by whole-exome sequencing (WES) |
| Investigator(s): | Chung BHY, Liu APY, Kan SYA, Hui PW, Chan YK, Yang W, Tang MHY, Sham PC |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2015 |
| Project Title: | Comprehensive Evaluation of Disable Infants and Children with Genetic Disorders |
| Investigator(s): | Chung BHY, Lau YL |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | The Society for the Relief of Disabled Children |
| Start Date: | 09/2015 |
| Project Title: | Identifying somatic mutations in PIK3CA-Related Overgrowth Spectrum – Implications for targeted therapeutic treatment |
| Investigator(s): | Chung BHY, Chan GCF |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2016 |
| Project Title: | 2016 American Society of Human Genetics (ASHG) Meeting; Use of Chromosomal Microarray in Hong Kong Patients with autism Spectrum Disorder - Implications of a Copy Number Variatin involving DPP10 |
| Investigator(s): | Chung BHY |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 10/2016 |
| Completion Date: | 10/2016 |
| Project Title: | Using Paired-end whole genome sequencing to investigate balanced chromosomal translocation associated with congenital anomalies/neurodevelopmental disorders |
| Investigator(s): | Chung BHY |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2017 |
| List of Research Outputs |
| Chan H.S.S., Fung C.W. and Chung B.H.Y., Improving genetic diagnosis by whole exome sequencing in rare hereditary peripheral neuropathies, Hong Kong College of Paediatricians 4th Annual Scientific Meeting cum 5th HK Guangdong Shanghai Chongquing Paediatric Exchange Meeting. 2016. |
| Chiu T.A., LEUNG K.C., Chu W.Y., Gripp K.W. and Chung B.H.Y., A novel patient with an attenuated Costello syndrome phenotype due to an HRAS mutation affecting codon 146-Literature review and update , American Journal of Medical Genetics Part A. 2017, 173: 1109-1114. |
| Chiu T.A., Zhu L., Mok T.K.G., LEUNG K.C., Chow C.B. and Chung B.H.Y., Before and after – Nutritional transformation of dysmorphism in a case of Costello syndrome, European Journal of Medical Genetics. 2016, 59: 573-576. |
| Chiu T.A., Chu W.Y., Kan S.Y.A. and Chung B.H.Y., What is the Diagnosis?, Hong Kong Journal of Paediatrics (new series). Medcom Limited, 2016, 21(4): 298,311-314. |
| Chu W.Y., Chu S.P.W., Mok W.K.Y., Tan T.Y. and Chung B.H.Y., Insights on sensitive language use in the Hong Kong healthcare setting: perceptions of parents and caregivers of patients with Down syndrome, Hong Kong Journal of Paediatrics. 2017, 22: 26-33. |
| Chu W.Y., LEUNG K.C., Mak A.S.L., Chiu T.A., MAK C.C.Y., Mok T.K.G., Tang W.F., Chan Y.K., Tang M.H.Y., Lau E.T.K., So K.W., Tao Q.V., Fung C.W., Wong V.C.N., Lee S.L., Marshall C., Scherer S., Kan S.Y.A. and Chung B.H.Y., Use of clinical chromosomal microarray in Hong Kong Chinese patients with autism spectrum disorder - Implication of a copy number variation involving DPP10, Asian Society for Pediatric Research (ASPR) and Faculty of Medicine Ramathibodi Hospital 2016, Thailand, Bangkok, 10-12 November 2016. |
| Chung B.H.Y., 遺傳代謝病 全港僅7患者, Apple Daily. 2016. |
| Chung B.H.Y., [動畫 - 不知飽的妹妹] 患小胖威利,症 食唔停, Apple Daily. 2016. |
| Chung B.H.Y., 長不大的進進 不放棄 患罕見病身形永遠如兩歲 昐狻新藥 [快啲高 快啲好], Apple Daily, 19 July 2016. 2016. |
| Chung B.H.Y., Application of NGS in paediatric patients in Hong Kong, International Symposium in Kanagawa 2017, PACIFICO Yokohama, Japan, 21-22 January 2017. |
| Chung B.H.Y., Associate Editor, Hong Kong Journal of Paediatrics 2017-2010. 2017. |
| Chung B.H.Y., Shuman C., Choufani S. and Weksberg R., Beckwith-Wiedemann Syndrome, UpToDate. 2017. |
| Chung B.H.Y., Chairman & Moderator - Rare Disease categories, Hong Kong Alliance for Rare Diseases 2017. 2017. |
| Chung B.H.Y., 基因測試是否有助診斷罕見疾病?, Choice Magazine. 選擇雜誌, 2017, 484: 38-40. |
| Chung B.H.Y., Clinical delineation of the recurrent de novo c.607>T mutation in PACS1, European Conference of Human Genetics 2017, Copenhagen, Denmark 27-30 May 2017. |
| Chung B.H.Y., Clinical delineation of the recurrent de novo c.607C>T mutation in PACS1, European Conference of Human Genetics 2017, Copenhagen, Denmark, 27-30 May 2017. |
| Chung B.H.Y., Discussion on group presentation/presentation topics/debates, Commissioned Programs on Genetic Counselling for Nurses Level II - Foundation Course, 11 January 2017. 2017. |
| Chung B.H.Y., Equipping nurses to take up the role of genetic counselors - better care for families at risk of genetic disorders in Hong Kong, Staff Development Department, Lesson Plan on In-house Program, St. Paul's Hospital. 11 May 2017. 2017. |
| Chung B.H.Y., Ethical issues and dilemmas in Genetics (I): Overview of Principles, Confidentiality & Privacy issue, Commissioned Programs on Genetic Counselling for Nurses Level II - Foundation Course, 11 January 2017. 2017. |
| Chung B.H.Y., Ethical issues in Genetics (II): Duty to re-contact and duty to warm, testing in minors, Commissioned Programs on Genetic Counselling for Nurses Level II - Foundation Course, 11 January 2017. 2017. |
| Chung B.H.Y., YEUNG K.S., Tso W.Y.W., Ying D., Ip J.K.J., Chu W.Y., LEUNG K.C. and MAK C.C.Y., Exome sequencing of a Chinese patient cohort with ID/ASD and macrocephaly/megalencephaly: Identification of a patient with biallelic PTEN mutations and others with germline/ post-zygotic mutations in PIK3C-AKT-mTOR pathway, 17th Manchester Dysmorphology Conference, Manchester, UK, 7-10 November 2016. |
| Chung B.H.Y., 看不見的罕見病, Fitness & Health, TVB Magazine. 2016. |
| Chung B.H.Y., Foundation in Genetics (I): Introduction to genetic counseling and Mendelian mode of inheritance, Commissioned Programs on Genetic Counselling for Nurses Level II - Foundation Course, 11 January 2017. 2017. |
| Chung B.H.Y., Genetic and genomic medicine in Asia - Application of NGS in paediatric patients in Hong Kong, The Progress of Neonatal Medicine in Asia, The International Symposium in Kanagawa 2017, Pacifico Yokohama, Japan. 2017. |
| Chung B.H.Y., Genetic assessment (I): Normal childhood development & techniques in taking perinatal, medical/developmental history, 2017. |
| Chung B.H.Y., Genetics of Congenital Heart Disease, PRCC in Cardiothoracic Surgical Nursing, 2016 -2017, HK. 18 May 2017. 2017. |
| Chung B.H.Y., Genetics of Connective Tissues, CME & CNE program, St. Paul’s Hospital, 11 May 2017. 2017. |
| Chung B.H.Y., Hong Kong doctors to be trained up as city faces shortage of clinical genetics experts, South China Morning Post. 2016. |
| Chung B.H.Y., Introduction and Human Genetics, Commissioned Programs on Genetic Counselling for Nurses Level II - Foundation Course, 11 January 2017. 2017. |
| Chung B.H.Y., Medical Consultant, Hong Kong MPS & Rare Genetic Diseases Mutual Aid Group. 2017. |
| Chung B.H.Y., Member (1 Dec 2016 - 30 Nov 2019), Committee on Continuing Medical Education (CME) Programme for Non-specialists. 2016. |
| Chung B.H.Y., Member, 2016-2017, Board for Graduate Studies (BoGS). 2016. |
| Chung B.H.Y., Member, Provisional Subspecialty Board in Genetics & Genomic Paediatrics (GGP). 2017. |
| Chung B.H.Y., 患結節性硬化症腦瘤長不停損智力 積極抗腫瘤畫出一片天, Ming Pao. 2016. |
| Chung B.H.Y., NGS in Paediatrics - discoveries and challenges, International Symposium in Kanagawa 2017, PACIFICO Yokohama, Japan, 21-22 January 2017. |
| Chung B.H.Y., NGS in Paediatrics - discoveries and challenges, The Progress of Neonatal Medicine in Asia, The International Symposium in Kanagawa 2017, Pacifico Yokohama, Japan. 2017. |
| Chung B.H.Y., NGS in Paediatrics: Promises, Challenges and a few things, Private Practising Paediatricians Study Group (PPPSG), 17 March 2017. 2017. |
| Chung B.H.Y., NGS in Paediatrics: promises, challenges and a few things, Practising Paediatricians Study Group, Hong Kong, 17 March 2017. 2017. |
| Chung B.H.Y., 侏儒症, Now TV + Viu TV 杏林在線. 2016. |
| Chung B.H.Y., Paediatrics (I): Syndromes & dysmorphology, Commissioned Programs on Genetic Counselling for Nurses Level II - Foundation Course, 11 January 2017. 2017. |
| Chung B.H.Y., Paediatrics (II): Teratology & Cardiovascular genetics, Commissioned Programs on Genetic Counselling for Nurses Level II - Foundation Course, 11 January 2017. 2017. |
| Chung B.H.Y., Paediatrics (III): Developmental Delay, Commissioned Programs on Genetic Counselling for Nurses Level II - Foundation Course, 11 January 2017. 2017. |
| Chung B.H.Y., Paediatrics (IV): Inborn errors of metabolism, Commissioned Programs on Genetic Counselling for Nurses Level II - Foundation Course, 11 January 2017. 2017. |
| Chung B.H.Y., Paediatrics (V): Paediatric Cancer Genetics, Commissioned Programs on Genetic Counselling for Nurses Level II - Foundation Course, 11 January 2017. 2017. |
| Chung B.H.Y., Reviewer, Clinical Case Reports. 2017. |
| Chung B.H.Y., Seminars: Patient group sharing, Commissioned Programs on Genetic Counselling for Nurses Level II - Foundation Course, 11 January 2017. 2017. |
| Chung B.H.Y., 生育前遺傳諮詢 可減唐氏嬰機會, Sing Tao Daily. 2017. |
| Chung B.H.Y., Speaker of panel discussion: molecular testing in Chinese around the World, ACGA Annual Meeting 2016, Vancouver, Canada, October 2016. 2016. |
| Chung B.H.Y., 巨人媽媽灌溉百厘米生命 你是我的禮物 從沒想過放棄, Tai Kung Pao Newspaer. 2017. |
| Chung B.H.Y., Training course launched as city faces shortage of clinical genetics experts, South China Morning Post, 16 October 2016. 2016. |
| Chung B.H.Y., Mak S.L., Chiu T.A., LEUNG K.C., MAK C.C.Y., Chu W.Y., Mok T.K.G., Chan Y.K., Kan S.Y.A., Tang M.H.Y., Lau E.T.K., Fung C.W. and Lee S.L., Use of chromosomal microarray in Hong Kong patients with autism spectrum disorder - implication of a copy number variation involving DPP10, ASHG 2016, Vancouver, Canada, 18-22 October 2016. |
| Chung B.H.Y., Video on direct consumer testing and discussion, Commissioned Programs on Genetic Counselling for Nurses Level II - Foundation Course, 11 January 2017. 2017. |
| Chung B.H.Y., 基因突變天使症, 有線電視 <至FIT 男女>, 2016. |
| Chung B.H.Y., 亨廷頓舞蹈症, 香港電台- 精靈一7點, 2017. |
| De Maria B., de Jager T., Sarubbi C., Bartsch O., Bianchi A., Brancati F., Chung B.H.Y., David A., Kariminejad A., Foresti M., Gallottini M., Isidor B., Marchegiani S., Martins F., Mazzanti L., Roche N., Singh A., Stevens C., Suga K., Zenker M. and Hennekam R.C., Barber-Say Syndrome and Ablepharon-Macrostomia Syndrome: A Patient's View, Molecular Syndromology. 2017, 8(4): 172-178. |
| Gripp K.W., Aldinger K.A., Bennett J., Baker L., Tusi J., Powell-Hamilton N., Stabley D., Sol-Church K., Timms A., Dobyns W.B., de Man A., Larson A., Spruijt L., Koolen D., Stevens S.J.C., Stegmann A.P.A., Nillesen M.W., Norrhock H.V., Belien M., Nellist M., Verheijen F., Wilems P.J., Chung B.H.Y., Dubbs H., Bhoj E., Santani A., McDougall C., Zackai E.H., Rinne T.K. and Wessels M.W., Recurrent de novo missense mutations in PP1CB cause a novel rasopathy closely resembling Noonan syndrome with loose anagen hair (Reviewer choice), Asian Society for Pediatric Research (ASPR) and Faculty of Medicine Ramathibodi Hospital ASHG 2016, Thailand, Bangkok, 10-12 November 2016. |
| Kruszka P., Addissie Y.A., McGinn D.E., Porras A.R., Biggs E., Share M., Crowley T.B., Chung B.H.Y., Mok T.K.G., MAK C.C.Y., Muthukumarasamy P., Thong M.K., Siriseria N.D., Dissanayake V.H.W., Paththinige C.S., Prabodha L.B.L., Mishra R., Shotelersuk V., Ekure E.N., Sokunbi O.J., Kalu N., Ferreira C.R., Duncan J.M., Patil S.J., Jones K.L., Kaplan J.D., Abdul-Rahman O.A., Uwineza A., Mutesa L., Moresco A., Obregon M.G., Richieri-Costa A., Gil-da-Silva-Lopes V.L., Adeyemo A.A., Summar M., Zackai E.H., McDonald-McGinn D.M., Linguraru M.G. and Muenke M., 22q11.2 deletion syndrome in diverse populations, American Journal of Medical Genetics Part A. 2017, 173: 879-888. |
| Kruszka P., Porras A.R., Sobering A.K., Ikolo F.A., Qua S.L., Shotelersuk V., Chung B.H.Y., Mok T.K.G., Uwineza A., Mutesa L., Moresco A., Obregon M.G., Sokunbi O.J., Kalu N., Joseph D.A., Ikebudu D., Ugwu C.E., Okoromah C.A.N., Addissie Y.A., Pardo K.L., Brough J.J., Lee N.C., Girisha K.M., Patil S.J., Ng I.S.L., Mim B.C.W., Jamuar S.S., Tibrewal S., Wallang B., Ganesh S., Sirisena N.D., Dissanayake V.H.W., Paththinige C.S., Prabodha L.B.L., Richieri-Costa A., Muthukumarasamy P., Thong M.K., Jones K.L., Abdul-Rahman O.A., Ekure E.N., Adeyemo A.A., Summar M., Linguraru M.G. and Muenke M., Down syndrome in diverse populations, American Journal of Medical Genetics Part A. 2017, 173: 42-53. |
| LEUNG K.C., Ying D., MAK C.C.Y., Chen X.Y., Xu W., YEUNG K.S., Wong W.L., Chu W.Y., Mok T.K.G., Chau S.K.C., McLuskey J., Ong W.P.T., Leong H.Y., Chan Y.K., Yang W., Chen J.H., Li A.M., Sham P.C., Lau Y.L., Chung B.H.Y. and Lee S.L., CFTR founder mutation causes protein trafficking defects in Chinese patients with cystic fibrosis , Molecular Genetics & Genomic Medicine. 2016. |
| LEUNG K.C., Ying D., MAK C.C.Y., Chen X.Y., Xu W., YEUNG K.S., Chu W.Y., Mok T.K.G., Chau S.K.C., McLuskey J., Ong W.P.T., Leong H.Y., Chan Y.K., Yang W., Chen J.H., Li A.M., Lau Y.L., Lee S.L. and Chung B.H.Y., Identification of a CFTR founder mutations, c.3068T>G:p.I1023R, which causes protein trafficking defects in Chinese patients with cystic fibrosis, Asian Society for Pediatric Research (ASPR) and Faculty of Medicine Ramathibodi Hospital 2016, Thailand, Bangkok, 10-12 November 2016. |
| LEUNG K.C., Ying D., Shek N.W.M., Chu W.Y., YEUNG K.S., Tang M.H.Y., Kan S.Y.A., Chan Y.K., Ip J.K.J., Yang W., Lau Y.L. and Chung B.H.Y., Identification of a novel homozygous missense mutation in ABR causing cerebellar hypoplasia with early lethality, Asian Society for Pediatric Research (ASPR) and Faculty of Medicine Ramathibodi Hospital 2016, Thailand, Bangkok, 10-12 November 2016. |
| Li Y.L., Ip J.K.J., Cheung K.K.Y., Chung B.H.Y. and Lam W.W.M., Radiological features of PIK3CA-related overgrowth spectrum (PROS), Hong Kong College of Radiology ASM, HK, 5 November 2016. |
| Luk H.M., YEUNG K.S., Wong W.L., Chung B.H.Y., Tong T.M.F. and Lo I.F.M., Silver-Russell syndrome in Hong Kong, Hong Kong Medical Journal. 2016, 22(6): 526-533. |
| MAK C.C.Y., Chow P.C., Liu A.P.Y., Chan Y.K., Chu W.Y., Mok T.K.G., LEUNG K.C., YEUNG K.S., Chau A.K.T., Lowther C., Scherer S.W., Marshall C.R., Bassett A.S. and Chung B.H.Y., De novo large rare copy-number variations contribute to conotruncal heart disease in Chinese patients, npj Genomic Medicine. 2016, 1: 16033. |
| Mok T.K.G., Fleischer N., Luk H.M. and Chung B.H.Y., Computer-aided facial recognition of Chinese individuals with Angelman Syndrome in Hong Kong, Asian Society for Pediatric Research (ASPR) and Faculty of Medicine Ramathibodi Hospital 2016, Thailand, Bangkok, 10-12 November 2016. |
| Mok T.K.G., Chu W.Y., Luk H.M. and Chung B.H.Y., Computer-aided facial recognition of Chinese individuals with Angelman syndrome in Hong Kong, Hong Kong College of Paediatricians, 4th Annual Scientific Meeting cum 5th Hong Kong-Guangdong-Shanghai-Chongqing Paediatric Exchange Meeting, HK, 3-4 December 2016. |
| Panagiotou E.S., Sanjurjo Soriano C., Poulter J.A., Lord E.C., Dzulova D., Kondo H., Hiyoshi A., Chung B.H.Y., Chu W.Y., Lai C.H.Y., Tafoya M.E., Karjosukarso D., Collin R.W.J., Topping J., Downey L.M., Ali M., Ingleheam C.F. and Toomes C., Defects in the Cell Signaling Mediator β-Catenin Cause the Retinal Vascular Condition FEVR, The American Journal of Human Genetics. 2017, 100: 960-968. |
| TSANG H.Y., LEUNG K.C., MAK C.C.Y., Miu X., Lee S.L., Chan G.C.F., Yung A.W.Y. and Chung B.H.Y., Genetic diagnosis of drug-resistant epilepsy by whole exome sequencing and chromosomal array in Hong Kong, Hong Kong College of Paediatricians, 4th Annual Scientific Meeting cum 5th Hong Kong-Guangdong-Shanghai-Chongqing Paediatric Exchange Meeting, HK, 3-4 December 2016. |
| TSANG H.Y., LEUNG K.C., MAK C.C.Y., Chu W.Y., Mu X., Lee S.L., Chan G.C.F., Yung A.W.Y. and Chung B.H.Y., Genetic diagnosis of early onset epilepsy by whole exome sequencing and chromosomal array in Hong Kong, Asian Society for Pediatric Research (ASPR) and Faculty of Medicine Ramathibodi Hospital 2016, Thailand, Bangkok, 10-12 November 2016. |
| Tso W.Y.W., YEUNG K.S., Ip J.K.J., Liu A.P.Y., Lee P.P.W., Chu W.Y., Chong C.Y., Ho M.H.K., Chan G.C.F., Lau Y.L. and Chung B.H.Y., The genetics of macrocephaly, autistic spectrum disorders and developmental delay in Chinese children. British Paediatric Neurology Association Annual Meeting, 11-13 January 2017, UK [Poster Presentations], Developmental Medicine & Child Neurology. 2017, 59: 19-108. |
| YEUNG K.S., Chung B.H.Y., Choufani S., Mok M.Y.T., Wong W.L., MAK C.C.Y., Yang W., Lee P.P.W., Wong W.H.S., Chen Y.A., Grafodatskaya D., Wong W.S.R., Lau W.C.S., Chan D.T.M., Weksberg R., Lau Y.L. and Crispin J.C., Genome-Wide DNA Methylation Analysis of Chinese Patients with Systemic Lupus Erythematosus Identified Hypomethylation in Genes Related to the Type I Interferon Pathway, PLOS ONE. 2017, 12: e0169553. |
| YEUNG K.S., Chung B.H.Y., Choufani S., Mok M.Y.T., Wong W.L., MAK C.C.Y., Yang W., Lee P.P.W., Wong W.H.S., Chen Y.A., Grafodatskaya D., Wong R.M.S., Lau W.C.S., Chan T.M., Weksberg R. and Lau Y.L., Genome-wide DNA methylation analysis of Chinese patients with systemic lupus erythematosus identified hypomethylation in genes to type I interferon pathway [PONE-D-16-30852R1], accepted, PLOS One. 2017. |
| YEUNG K.S., Ip J.K.J., Chow C.P., Kuong E.E.Y.L., Tam P.K.H., Chan G.C.F. and Chung B.H.Y., Somatic PIK3CA mutations in seven patients with PIK3CA-related overgrowth spectrum, American Journal of Medical Genetics Part A. 2017, 173A: 978-984. |
| van Damme T., Gardenchik T., Mohamed M., Gucerrero-Castillo S., Freisinger P., Guillemyn B., Kariminejad A., Dalloyaux D., van Kraaij S., Lefeber D.J., Syx D., Steyaert W., De Rycke R., Hotschen A., Kamstccg E.J., Wong S.Y., van Scherpenzeei M., Jamali P., Brandt U., Nijtmans L., Korenke C., Chung B.H.Y., MAK C.C.Y., Hausser I., Kornak U., Fischer-Zirnsak B., Strom T.M., Meitinger T., Alanay Y., Utine G.E., Leung P.K.C., Ghadcri-Soli S., Coucke P., Symoens S., De Paepe A., Thiel C., Haack T.B., Malfair F., Morava E. and Callewaert B., Mutations in ATP6V1E1 or ATP6V1A cause AR cutis laxia, Asian Society for Pediatric Research (ASPR) and Faculty of Medicine Ramathibodi Hospital ASHG 2016, Thailand, Bangkok, 10-12 November 2016. |
| van Damme T., Gardeitchik T., Mohamed M., Guerrero-Castillo S., Freisinger P., Guillemyn B., Kariminejad A., Dalloyaux D., van Kraaij S., Lefeber D.J., Syx D., Steyaert W., DeRycke R., Hoischen A., Kamsteeg E.J., Wong S.Y., van Scherpenzeel M., Jamali P., Brandt P., Nijtmans L., Korenke G.C., Chung B.H.Y., MAK C.C.Y., Hausser I., Kornak U., Fischer-Zirnsak B., Strom T.M., Meitinger T., Alanay Y., Utine G.E., Leung K.C.P., Ghaderi-Sohi S., Coucke P., Symoens S., De Paepe A., Thiel C., Haack T.B., Malfait F., Morava E., Callewaert B. and Wevers R.A., Mutations in ATP6V1E1 or ATP6V1A cause autosomal-recessive cutis laxa, The American Journal of Human Genetics. 2017, 100: 2. |
| Researcher : Fung CW |
| Project Title: | Neurogenetic Project |
| Investigator(s): | Fung CW |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | The Society for the Relief of Disabled Children |
| Start Date: | 05/2016 |
| Project Title: | Pilot Programme for Diagnosis and Management of Mitochondrial Diseases |
| Investigator(s): | Fung CW |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | The Society for the Relief of Disabled Children |
| Start Date: | 05/2016 |
| Project Title: | Territory-wide Mitochondrial Disease Registry in Hong Kong (Phase I) and Territory-wide Inborn Errors of Metabolism Registry in Hong Kong (Phase II) |
| Investigator(s): | Fung CW |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | The Joshua Hellmann Foundation for Orphan Disease |
| Start Date: | 06/2017 |
| List of Research Outputs |
| Chan H.S.S., Fung C.W. and Chung B.H.Y., Improving genetic diagnosis by whole exome sequencing in rare hereditary peripheral neuropathies, Hong Kong College of Paediatricians 4th Annual Scientific Meeting cum 5th HK Guangdong Shanghai Chongquing Paediatric Exchange Meeting. 2016. |
| Chu W.Y., LEUNG K.C., Mak A.S.L., Chiu T.A., MAK C.C.Y., Mok T.K.G., Tang W.F., Chan Y.K., Tang M.H.Y., Lau E.T.K., So K.W., Tao Q.V., Fung C.W., Wong V.C.N., Lee S.L., Marshall C., Scherer S., Kan S.Y.A. and Chung B.H.Y., Use of clinical chromosomal microarray in Hong Kong Chinese patients with autism spectrum disorder - Implication of a copy number variation involving DPP10, Asian Society for Pediatric Research (ASPR) and Faculty of Medicine Ramathibodi Hospital 2016, Thailand, Bangkok, 10-12 November 2016. |
| Chung B.H.Y., Mak S.L., Chiu T.A., LEUNG K.C., MAK C.C.Y., Chu W.Y., Mok T.K.G., Chan Y.K., Kan S.Y.A., Tang M.H.Y., Lau E.T.K., Fung C.W. and Lee S.L., Use of chromosomal microarray in Hong Kong patients with autism spectrum disorder - implication of a copy number variation involving DPP10, ASHG 2016, Vancouver, Canada, 18-22 October 2016. |
| Fung C.W., Kwong K.Y. and Wong C.N.V., Gene panel analysis for nonsyndromic cryptogenic neonatal/infantile epileptic encephalopathy, Epilepsia Open. 2017, 2: 236-243. |
| Koene S., Hendriks J.C.M., Dirks I., de Boer L., de Vries M.C., Janssen M.C.H., Smuts I., Fung C.W., Wong C.N.V., de Coo I.R.F.M., Vill K., Stendel C., Klopstock T., Falk M.J., McCormick E.M., McFarland R., de Groot I.J.M. and Smeitink J.A.M., International Paediatric Mitochondrial Disease Scale, Journal of Inherited Metabolic Disease. 2016, 39: 705-712. |
| Palmigiano A., Bua R.O., Barone R., Rymen D., Legal L., Deconinck N., Dionisi-Vici C., Fung C.W., Garozzo D., Jaeken J. and Sturiale L., MALDI-MS profiling of serum O-glycosylation and N-glycosylation in COG5-CDG , Journal of Mass Spectrometry. 2017, 52: 372-377. |
| Wong S.S.N., Goraj B., Fung C.W., Vister J., de Boer L., Koene S. and Smeitink J., Radboud Centre for Mitochondrial Medicine Pediatric MRI score, Mitochondrion. 2017, 32: 36-41. |
| Researcher : GUO M |
| List of Research Outputs |
| Kwok J.S.Y., GUO M., Yang W., Lee C.K., Chan N.K., Ho J., Tang W.H., Chan Y.S., Middleton D., Lu L. and Chan G.C.F., HLA-A, -B and -DRB1 genotyping and haplotype frequencies of 3892 cord blood units in the Hong Kong Chinese Cord Blood Registry, Human Immunology. 2016, 77: 1109-1110. |
| Kwok J.S.Y., GUO M., Yang W., Lee C.K., Ho J., Tang W.H., Chan Y.S., Middleton D., Lu L. and Chan G.C.F., HLA-A, -B, -C, and -DRB1 genotyping and haplotype frequencies for a Hong Kong Chinese population of 7595 individuals, Human Immunology. ELSEVIER, 2016, 77: 1111-1112. |
| WANG Y., GUO M., WANG T., Zhang Y., Yang J., Lau Y.L. and Yang W., Functional Properties of Genomic Region Associated with Multiple Traits in Genome-Wide Association Studies, The American Society of Human Genetics 2016. |
| Researcher : HUANG C |
| List of Research Outputs |
| Diao L.H., Li G.G., Zhu Y.C., Tu W., HUANG C., Lian R.C., Chen X., Li Y.Y., Zhang T., Huang Y. and Zeng Y., Human chorionic gonadotropin potentially affects pregnancy outcome in women with recurrent implantation failure by regulating the homing preference of regulatory T cells, American Journal of Reproductive Immunology. 2017, 77: e12618. |
| Researcher : Ha SY |
| List of Research Outputs |
| Cheuk K.L.D., Chiang A.K.S., Chan G.C.F. and Ha S.Y., Urate oxidase for the prevention and treatment of tumour lysis syndrome in children with cancer, In: The Cochrane Collaboration, Cochrane Database of Systematic Reviews: Reviews. Chichester, UK, John Wiley & Sons, Ltd, 2017. |
| See W.S.Q., Cheuk K.L.D., To K.F., Ip P.C.P., Chiang A.K.S., Ha S.Y. and Chan G.C.F., Congenital intestinal fibrosarcoma with rapid recurrence requiring adjuvant chemotherapy, Pediatrics International. 2017. |
| See W.S.Q., Chang K.O., Cheuk K.L.D., Leung Y.R., Chan G.C.F., Chan S.C. and Ha S.Y., Inhibitor development after liver transplantation in congenital factor VII deficiency, Haemophilia. 2016, 22(5): e417-422. |
| Researcher : Ho KW |
| List of Research Outputs |
| Chow C.B., Wong W.H.S., Leung W.C., Tang M.H.Y., Chan E.K.L., Or C.K.L., Li M.H., Ho K.W., Lo D. and Ip P., Effectiveness of Internet-based injury prevention program in enhancing mother’s knowledge on child safety, JMIR Res Protoc. 2016. |
| Ip P., Ho K.W., Chan E.K.L. and Yip P.S.F., Child maltreatment hospitalizations in Hong Kong from 2001 to 2010: Incidence rate and seasonal pattern, Arch Dis Child. 2016. |
| Ip P., Chim D., Chan E.K.L., Li M.H., Ho K.W., Voorhees B.W.V., Tiwari A., Tsang A.M.C., Chan C.W.L., Ho S.P., Tso W.Y.W. and Wong W.H.S., Effectiveness of a Culturally Attuned Internet-based Depression Prevention Program for Chinese Adolescents: A Randomized Controlled Trial, Depression and Anxiety. 2016. |
| Researcher : Ho MHK |
| List of Research Outputs |
| Lee T.H., Ho M.H.K. and Leung T.F., Genetically modified foods and allergy, Hong Kong Medical Journal. 2017, 23(3): 291-295. |
| Leung N.Y., Wai C.Y., Ho M.H.K., Liu R., Lam K.S., Wang J.J., Shu S.A., Chu K.H. and Leung P.S., Screening and identification of mimotopes of the major shrimp allergen tropomyosin using one-bead-one-compound peptide libraries, Cellular & Molecular Immunology. 2017, 14: 308-318. |
| Tso W.Y.W., YEUNG K.S., Ip J.K.J., Liu A.P.Y., Lee P.P.W., Chu W.Y., Chong C.Y., Ho M.H.K., Chan G.C.F., Lau Y.L. and Chung B.H.Y., The genetics of macrocephaly, autistic spectrum disorders and developmental delay in Chinese children. British Paediatric Neurology Association Annual Meeting, 11-13 January 2017, UK [Poster Presentations], Developmental Medicine & Child Neurology. 2017, 59: 19-108. |
| Researcher : Ho SP |
| Project Title: | Understanding the molecular pathogenesis of osteosarcoma |
| Investigator(s): | Ho SP, Chan D, Chan GCF |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2016 |
| List of Research Outputs |
| Ip P., Chim D., Chan E.K.L., Li M.H., Ho K.W., Voorhees B.W.V., Tiwari A., Tsang A.M.C., Chan C.W.L., Ho S.P., Tso W.Y.W. and Wong W.H.S., Effectiveness of a Culturally Attuned Internet-based Depression Prevention Program for Chinese Adolescents: A Randomized Controlled Trial, Depression and Anxiety. 2016. |
| Researcher : Hui KF |
| Project Title: | Sensitization of nasopharyngeal carcinoma to radiotherapy and chemotherapy by induction of DNA damage response pathway |
| Investigator(s): | Hui KF, Chiang AKS |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 04/2015 |
| Completion Date: | 09/2016 |
| Project Title: | 17th International Symposium on EBV and associated diseases; Targeting the survival function of ebna-3c protein in ebv-positive burkitt and lymphoblastoid cells by histone deacetylase and proteasome inhibitors |
| Investigator(s): | Hui KF |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2016 |
| Completion Date: | 08/2016 |
| List of Research Outputs |
| Hui K.F., Outstanding Poster Presentation Award, Gordon Research Conference on Nasopharyngeal Carcinoma, HKUST. 2016. |
| Hui K.F., YEUNG P.L. and Chiang A.K.S., Targeting the survival function of ebna-3c protein in ebv-positive burkitt and lymphoblastoid cells by histone deacetylase and proteasome inhibitors, 17th Symposium on Epstein Barr Virus and Associated Disease, Zurich, Switzerland. 2016. |
| Researcher : Ip P |
| Project Title: | Promoting alcohol-related attitudinal and behavioural change amongst adolescents through Internet intervention: A cluster randomised controlled trial |
| Investigator(s): | Ip P, Chow CB, Lam TH, Ho DSY, Wong WHS |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 07/2015 |
| Project Title: | Attention-deficit/hyperactivity disorder and child maltreatment: A population-based study |
| Investigator(s): | Ip P, Chan EKL, Fong DYT, Sham PC |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2016 |
| List of Research Outputs |
| B C.H., Fung C.H., H R.N., B E.B., Tse T.H., Fu K.W., Ip P. and Basch C., Zika Virus on YouTube: An Analysis of English-language Video Content by Source, Journal of Preventive Medicine and Public Health. 2017, 50: 133-140. |
| Britto P.R., Lye S., Proulx K., Yousafzai A.K., Matthews S.G., Peresz-Escamilla R., Rao N., Ip P. and Fernald L.C., Nurturing Care: Science and Effective Interventions to Promote Early Childhood Development, Lancet. 2016. |
| Chan K.L., Emery C.R., Fulu E., Tolman R.M. and Ip P., Association Among Father Involvement, Partner Violence, and Paternal Health: UN Multi-Country Cross-Sectional Study on Men and Violence., The American Journal of Preventive Medicine. 2017, 671-679. |
| Chow C.B., Wong W.H.S., Leung W.C., Tang M.H.Y., Chan E.K.L., Or C.K.L., Li M.H., Ho K.W., Lo D. and Ip P., Effectiveness of Internet-based injury prevention program in enhancing mother’s knowledge on child safety, JMIR Res Protoc. 2016. |
| Fu K.W., Ho F.K.W., Rao N., Fan F.J., Li L., Lee T.M.C., Chan H.S.S., Yung A.W.Y., Young Y.M.E. and Ip P., Parental restriction reduces the harmful effects of in-bedroom electronic devices, Archives of Disease in Childhood. 2017, archdischild-2017-312639. |
| Ip P., Ho K.W., Chan E.K.L. and Yip P.S.F., Child maltreatment hospitalizations in Hong Kong from 2001 to 2010: Incidence rate and seasonal pattern, Arch Dis Child. 2016. |
| Ip P., Chim D., Chan E.K.L., Li M.H., Ho K.W., Voorhees B.W.V., Tiwari A., Tsang A.M.C., Chan C.W.L., Ho S.P., Tso W.Y.W. and Wong W.H.S., Effectiveness of a Culturally Attuned Internet-based Depression Prevention Program for Chinese Adolescents: A Randomized Controlled Trial, Depression and Anxiety. 2016. |
| Lo C.K.M., Tung T.S., Chan L.K., Yip P.S.F., Lau J.T.F., Wong W.H.S., Wong R.S.M., Tsang A.M.C., Tsang H.Y.H., Tso W.Y.W. and Ip P., Risk factors for child physical abuse and neglect among Chinese young mothers, Child Abuse & Neglect. 2017, 67: 193-206. |
| Man K.C.K., Coghill D., Chan E.W., LAU C.Y., Hollis C., Liddle E., Banaschewski T., McCarthy S., Neubert A., Sayal K., Ip P. and Wong I.C.K., Methylphenidate and the risk of psychotic disorders and hallucinations in children and adolescents in a large health system, Translational Psychiatry. Nature Publishing Group, 2016, 6(11): e956. |
| Man K.C.K., Chan E.W., Ip P., Coghill D.R., Simonoff E., Chan P.K.L., LAU C.Y., Schuemie M.J., Sturkenboom M.C.J.M. and Wong I.C.K., Prenatal antidepressant use and risk of attention-deficit/hyperactivity disorder in offspring: population based cohort study, BMJ. 2017, j2350. |
| Rao N., Richards B.D., Umayahara M..., Sun J..., Bacon-Shone J., Ip P., Lee P.L.D. and Becher Y..., Myanmar East Asia- Pacific Early Child Development Scales (EAP-ECDS) Project, UNICEF Myanmar. Myanmar, 2017. |
| Rao N., Sun J..., Weber A..., Sincovich A..., Ip P. and Darmstadt G...L..., Stunting and School Readiness in East Asia and the Pacific, Poster presented at the biennial meeting of the Society for Research in Child Development Conference. Austin, USA, 2017. |
| WONG R.S.M., Guo Y., Ip P., Wong C.K.H., Yu Y.T.E., Fung S.C.C. and Lam C.L.K., Mothers’ health-related quality of life: Its relationship with children’s health-related quality of life and behavior in low-income families, Family Medicine and Community Health. 2016, 4: 4-12. |
| Zhang H., Wong W.C., Ip P., Lai G.W.F., Lam T.H., Lam K.F., Fan S., Cheung D.Y.T., Lee A., Zhang Y. and Yip P.S., A Study of Violence Among Hong Kong Young Adults and Associated Substance Use, Risky Sexual Behaviors, and Pregnancy, Violence Vict. 2016. |
| Researcher : Kong MCW |
| List of Research Outputs |
| Keung W.W.Y., Ren L., Li S., Wong A.O., Chopra A., Kong M.C.W., Tomaselli G.F., Chen C.S. and Li R.A., Non-cell autonomous cues for enhanced functionality of human embryonic stem cell-derived cardiomyocytes via maturation of sarcolemmal and mitochondrial KATP channels, Scientific Reports. 2016, 6: 34154. |
| Researcher : Kwong KY |
| List of Research Outputs |
| Fung C.W., Kwong K.Y. and Wong C.N.V., Gene panel analysis for nonsyndromic cryptogenic neonatal/infantile epileptic encephalopathy, Epilepsia Open. 2017, 2: 236-243. |
| Researcher : LEUNG KC |
| List of Research Outputs |
| Chiu T.A., LEUNG K.C., Chu W.Y., Gripp K.W. and Chung B.H.Y., A novel patient with an attenuated Costello syndrome phenotype due to an HRAS mutation affecting codon 146-Literature review and update , American Journal of Medical Genetics Part A. 2017, 173: 1109-1114. |
| Chiu T.A., Zhu L., Mok T.K.G., LEUNG K.C., Chow C.B. and Chung B.H.Y., Before and after – Nutritional transformation of dysmorphism in a case of Costello syndrome, European Journal of Medical Genetics. 2016, 59: 573-576. |
| Chu W.Y., LEUNG K.C., Mak A.S.L., Chiu T.A., MAK C.C.Y., Mok T.K.G., Tang W.F., Chan Y.K., Tang M.H.Y., Lau E.T.K., So K.W., Tao Q.V., Fung C.W., Wong V.C.N., Lee S.L., Marshall C., Scherer S., Kan S.Y.A. and Chung B.H.Y., Use of clinical chromosomal microarray in Hong Kong Chinese patients with autism spectrum disorder - Implication of a copy number variation involving DPP10, Asian Society for Pediatric Research (ASPR) and Faculty of Medicine Ramathibodi Hospital 2016, Thailand, Bangkok, 10-12 November 2016. |
| Chung B.H.Y., YEUNG K.S., Tso W.Y.W., Ying D., Ip J.K.J., Chu W.Y., LEUNG K.C. and MAK C.C.Y., Exome sequencing of a Chinese patient cohort with ID/ASD and macrocephaly/megalencephaly: Identification of a patient with biallelic PTEN mutations and others with germline/ post-zygotic mutations in PIK3C-AKT-mTOR pathway, 17th Manchester Dysmorphology Conference, Manchester, UK, 7-10 November 2016. |
| Chung B.H.Y., Mak S.L., Chiu T.A., LEUNG K.C., MAK C.C.Y., Chu W.Y., Mok T.K.G., Chan Y.K., Kan S.Y.A., Tang M.H.Y., Lau E.T.K., Fung C.W. and Lee S.L., Use of chromosomal microarray in Hong Kong patients with autism spectrum disorder - implication of a copy number variation involving DPP10, ASHG 2016, Vancouver, Canada, 18-22 October 2016. |
| LEUNG K.C., Ying D., MAK C.C.Y., Chen X.Y., Xu W., YEUNG K.S., Wong W.L., Chu W.Y., Mok T.K.G., Chau S.K.C., McLuskey J., Ong W.P.T., Leong H.Y., Chan Y.K., Yang W., Chen J.H., Li A.M., Sham P.C., Lau Y.L., Chung B.H.Y. and Lee S.L., CFTR founder mutation causes protein trafficking defects in Chinese patients with cystic fibrosis , Molecular Genetics & Genomic Medicine. 2016. |
| LEUNG K.C., Ying D., MAK C.C.Y., Chen X.Y., Xu W., YEUNG K.S., Chu W.Y., Mok T.K.G., Chau S.K.C., McLuskey J., Ong W.P.T., Leong H.Y., Chan Y.K., Yang W., Chen J.H., Li A.M., Lau Y.L., Lee S.L. and Chung B.H.Y., Identification of a CFTR founder mutations, c.3068T>G:p.I1023R, which causes protein trafficking defects in Chinese patients with cystic fibrosis, Asian Society for Pediatric Research (ASPR) and Faculty of Medicine Ramathibodi Hospital 2016, Thailand, Bangkok, 10-12 November 2016. |
| LEUNG K.C., Ying D., Shek N.W.M., Chu W.Y., YEUNG K.S., Tang M.H.Y., Kan S.Y.A., Chan Y.K., Ip J.K.J., Yang W., Lau Y.L. and Chung B.H.Y., Identification of a novel homozygous missense mutation in ABR causing cerebellar hypoplasia with early lethality, Asian Society for Pediatric Research (ASPR) and Faculty of Medicine Ramathibodi Hospital 2016, Thailand, Bangkok, 10-12 November 2016. |
| MAK C.C.Y., Chow P.C., Liu A.P.Y., Chan Y.K., Chu W.Y., Mok T.K.G., LEUNG K.C., YEUNG K.S., Chau A.K.T., Lowther C., Scherer S.W., Marshall C.R., Bassett A.S. and Chung B.H.Y., De novo large rare copy-number variations contribute to conotruncal heart disease in Chinese patients, npj Genomic Medicine. 2016, 1: 16033. |
| TSANG H.Y., LEUNG K.C., MAK C.C.Y., Miu X., Lee S.L., Chan G.C.F., Yung A.W.Y. and Chung B.H.Y., Genetic diagnosis of drug-resistant epilepsy by whole exome sequencing and chromosomal array in Hong Kong, Hong Kong College of Paediatricians, 4th Annual Scientific Meeting cum 5th Hong Kong-Guangdong-Shanghai-Chongqing Paediatric Exchange Meeting, HK, 3-4 December 2016. |
| TSANG H.Y., LEUNG K.C., MAK C.C.Y., Chu W.Y., Mu X., Lee S.L., Chan G.C.F., Yung A.W.Y. and Chung B.H.Y., Genetic diagnosis of early onset epilepsy by whole exome sequencing and chromosomal array in Hong Kong, Asian Society for Pediatric Research (ASPR) and Faculty of Medicine Ramathibodi Hospital 2016, Thailand, Bangkok, 10-12 November 2016. |
| Researcher : LI WYV |
| List of Research Outputs |
| Yu C.K., Wong W.H., LI W.Y.V. and Cheung Y.F., Left ventricular stiffness in adolescents and young adults with repaired tetralogy of Fallot., Scientific Reports. 2017, 7: 1252. |
| Researcher : Lam KT |
| List of Research Outputs |
| Liu Y., Zheng J., Liu Y., WEN L., Huang L., Xiang Z., Lam K.T., Lv A., Mao H., Lau Y.L. and Tu W., Uncompromised NK cell activation is essential for virus-specific CTL activity during acute influenza virus infection, Cellular & Molecular Immunology. 2017. |
| Researcher : Lau ASY |
| Project Title: | Cytokines, Signaling & Diseases 2003 The Role of Protein Kinase PKR in the Induction of Cytokine Expression by Bacillus Calmette Guerin Through NF-kappaB |
| Investigator(s): | Lau ASY |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 10/2003 |
| Project Title: | Cytokine Dysregulation and Virus-Induced Cell Death in Avian Influenza Virus Infections |
| Investigator(s): | Lau ASY, Peiris JSM |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2005 |
| Project Title: | Factors affecting mycobacteria evasion of immunity: effects of HIV on cellular signaling and kinases |
| Investigator(s): | Lau ASY |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 09/2009 |
| List of Research Outputs |
| Lau A.S.Y., Yang L.H., Chik S.C.C., Law H.Y. and Lee D.C.W., Coriolus Versicolor Extracts, Methods of Preparation and Uses Thereof. Japanese patent No. 5959523., 2016. |
| Law H.Y., Yang L.H., Lau A.S.Y. and Chan G.C.F., Mechanism of action and molecular identification of individual bio-active constituents from an effective traditional Chinese medicine decoction in treating influenza virus infection. Submitted to Journal of Antimicrobial Chemotherapy, 2016. |
| Researcher : Lau YL |
| Project Title: | A community-based educational program on thalassaemias to enhance awareness with the aim to reduce burden of thalassaemia related health problems in Hong Kong |
| Investigator(s): | Lau YL, Ha SY |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Health Promotion Projects |
| Start Date: | 09/1997 |
| Project Title: | Comparison of process upgrade varicella vaccine (Puvv) with VARILRIX-TM |
| Investigator(s): | Lau YL |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Other Funding Scheme |
| Start Date: | 07/1999 |
| Project Title: | Association of cytokine and chemokine genes polymorphism with susceptibility to SARS and severity of SARS |
| Investigator(s): | Lau YL, Peiris JSM |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 09/2005 |
| Project Title: | p21 gene polymorphism with systemic lupus erythematosus and rheumatoid arthritis |
| Investigator(s): | Lau YL, Lau WCS |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2005 |
| Project Title: | The effects of BTK mutation on TLR3-mediated type I IFN response against poliovirus infection in X-linked agammaglobulinemia |
| Investigator(s): | Lau YL, Tu W, Lee PPW |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Completion Date: | 01/2018 |
| List of Research Outputs |
| Ben-Ali M., Yang J., Chan K.W., Ben-Mustapha I., Yang W., Lau Y.L. and Barbouche M.R., Homozygous transcription factor 3 gene (TCF3) mutation is associated with severe hypogammaglobulinemia and B-cell acute lymphoblastic leukemia., J Allergy Clin Immunol.. 2017, S0091-6749(17)30794-7. |
| CHEN R., Lau Y.L., Zhang Y. and Yang W., SRinversion: a tool for detecting short inversions by splitting and re-aligning poorly mapped and unmapped sequencing reads, Bioinformatics. Oxford University Press, 2016, 32: 3559-3565. |
| LEUNG K.C., Ying D., MAK C.C.Y., Chen X.Y., Xu W., YEUNG K.S., Wong W.L., Chu W.Y., Mok T.K.G., Chau S.K.C., McLuskey J., Ong W.P.T., Leong H.Y., Chan Y.K., Yang W., Chen J.H., Li A.M., Sham P.C., Lau Y.L., Chung B.H.Y. and Lee S.L., CFTR founder mutation causes protein trafficking defects in Chinese patients with cystic fibrosis , Molecular Genetics & Genomic Medicine. 2016. |
| LEUNG K.C., Ying D., MAK C.C.Y., Chen X.Y., Xu W., YEUNG K.S., Chu W.Y., Mok T.K.G., Chau S.K.C., McLuskey J., Ong W.P.T., Leong H.Y., Chan Y.K., Yang W., Chen J.H., Li A.M., Lau Y.L., Lee S.L. and Chung B.H.Y., Identification of a CFTR founder mutations, c.3068T>G:p.I1023R, which causes protein trafficking defects in Chinese patients with cystic fibrosis, Asian Society for Pediatric Research (ASPR) and Faculty of Medicine Ramathibodi Hospital 2016, Thailand, Bangkok, 10-12 November 2016. |
| LEUNG K.C., Ying D., Shek N.W.M., Chu W.Y., YEUNG K.S., Tang M.H.Y., Kan S.Y.A., Chan Y.K., Ip J.K.J., Yang W., Lau Y.L. and Chung B.H.Y., Identification of a novel homozygous missense mutation in ABR causing cerebellar hypoplasia with early lethality, Asian Society for Pediatric Research (ASPR) and Faculty of Medicine Ramathibodi Hospital 2016, Thailand, Bangkok, 10-12 November 2016. |
| Lee S.L., O'Callaghan C., Lau Y.L. and Lee D.C.W., Functional analysis and evaluation of ultrastructure of respiratory cilia in healthy Chinese children in Hong Kong, Health Research Symposium (HRS)2017, Hong Kong, 16 June 2017. |
| Lee S.L., Lau Y.L., Wong W.H.S. and Tian L., Prevalence of and Risk Factors for Childhood Asthma, Rhinitis, and Eczema in Hong Kong: Proposal for a Cross-Sectional Survey, JMIR Research Protocols. 2017, 6: e106. |
| Liu Y., Zheng J., Liu Y., WEN L., Huang L., Xiang Z., Lam K.T., Lv A., Mao H., Lau Y.L. and Tu W., Uncompromised NK cell activation is essential for virus-specific CTL activity during acute influenza virus infection, Cellular & Molecular Immunology. 2017. |
| Mao H., Liu Y., Sia S.F., Peiris J.S.M., Lau Y.L. and Tu W., Avian influenza virus directly infects human natural killer cells and inhibits cell activity, Virologica Sinica. 2017, 32(2): 122-9. |
| Molineros J.E., Yang W., Zhou X.J., Sun C., Okada Y., ZHANG H., Heng Chua K., Lau Y.L., Kochi Y., Suzuki A., Yamamoto K., Ma J., Bang S.Y., Lee H.S., Kim K K., Bae S.C., Zhang H., Shen N., Looger L.L. and Nath SK S.K., Confirmation of five novel susceptibility loci for systemic lupus erythematosus (SLE) and integrated network analysis of 82 SLE susceptibility loci., Human Molecular Genetics. Oxford University Press, 2017, 26: 1205-1216. |
| Morris D.L., Sheng Y., Zhang Y., WANG Y., Zhu Z., Tombleson P., Chen L., Cunninghame Graham D.S., Bentham J., Roberts A.L., CHEN R., Zuo X., WANG T., Wen L., Yang C., Liu L., Yang L., Li F., Huang Y., Yin X., Yang S., Rönnblom L., Fürnrohr B.G., Voll R.E., Schett G., Costedoat-Chalumeau N., Gaffney P.M., Lau Y.L., Zhang X X., Yang W., Cui Y. and Vyse T.J., Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus., Nature Genetics. 2016, 48: 940–946. |
| Tso W.Y.W., YEUNG K.S., Ip J.K.J., Liu A.P.Y., Lee P.P.W., Chu W.Y., Chong C.Y., Ho M.H.K., Chan G.C.F., Lau Y.L. and Chung B.H.Y., The genetics of macrocephaly, autistic spectrum disorders and developmental delay in Chinese children. British Paediatric Neurology Association Annual Meeting, 11-13 January 2017, UK [Poster Presentations], Developmental Medicine & Child Neurology. 2017, 59: 19-108. |
| WANG Y., GUO M., WANG T., Zhang Y., Yang J., Lau Y.L. and Yang W., Functional Properties of Genomic Region Associated with Multiple Traits in Genome-Wide Association Studies, The American Society of Human Genetics 2016. |
| YEUNG K.S., Chung B.H.Y., Choufani S., Mok M.Y.T., Wong W.L., MAK C.C.Y., Yang W., Lee P.P.W., Wong W.H.S., Chen Y.A., Grafodatskaya D., Wong W.S.R., Lau W.C.S., Chan D.T.M., Weksberg R., Lau Y.L. and Crispin J.C., Genome-Wide DNA Methylation Analysis of Chinese Patients with Systemic Lupus Erythematosus Identified Hypomethylation in Genes Related to the Type I Interferon Pathway, PLOS ONE. 2017, 12: e0169553. |
| YEUNG K.S., Chung B.H.Y., Choufani S., Mok M.Y.T., Wong W.L., MAK C.C.Y., Yang W., Lee P.P.W., Wong W.H.S., Chen Y.A., Grafodatskaya D., Wong R.M.S., Lau W.C.S., Chan T.M., Weksberg R. and Lau Y.L., Genome-wide DNA methylation analysis of Chinese patients with systemic lupus erythematosus identified hypomethylation in genes to type I interferon pathway [PONE-D-16-30852R1], accepted, PLOS One. 2017. |
| Researcher : Law HY |
| List of Research Outputs |
| Lau A.S.Y., Yang L.H., Chik S.C.C., Law H.Y. and Lee D.C.W., Coriolus Versicolor Extracts, Methods of Preparation and Uses Thereof. Japanese patent No. 5959523., 2016. |
| Law H.Y., Yang L.H., Lau A.S.Y. and Chan G.C.F., Mechanism of action and molecular identification of individual bio-active constituents from an effective traditional Chinese medicine decoction in treating influenza virus infection. Submitted to Journal of Antimicrobial Chemotherapy, 2016. |
| Researcher : Lee DCW |
| List of Research Outputs |
| Lau A.S.Y., Yang L.H., Chik S.C.C., Law H.Y. and Lee D.C.W., Coriolus Versicolor Extracts, Methods of Preparation and Uses Thereof. Japanese patent No. 5959523., 2016. |
| Lee S.L., O'Callaghan C., Lau Y.L. and Lee D.C.W., Functional analysis and evaluation of ultrastructure of respiratory cilia in healthy Chinese children in Hong Kong, Health Research Symposium (HRS)2017, Hong Kong, 16 June 2017. |
| Researcher : Lee PPW |
| Project Title: | The role of NLRP3 inflammasome in the induction of protective Th1 and Th17 immune response towards Penicillium marneffei |
| Investigator(s): | Lee PPW, Lau YL, Woo PCY, Tu W, Chan JFW |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | St Jude-VIVA Forum ; Allogeneic Haematopoietic Stem Cell Transplant Using Reduced-Intensity Conditioning Consisting of Fludarabine and Targeted Busulphan Administration: A Safe and Efficacious Approach for Curing Congenital Phagocytic Disorders |
| Investigator(s): | Lee PPW |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 03/2017 |
| Completion Date: | 03/2017 |
| List of Research Outputs |
| Liu A.P.Y., Leung Y.Y., Kwok J.S.Y., Chiang A.K.S., Ha S.Y., Lee P.P.W., Cheuk D.K.L. and Chan G.C.F., HAPLOIDENTICAL HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR RELAPSED/REFRACTORY OR METASTATIC PEDIATRIC SOLID TUMORS, SIOP Asia 2017. |
| Tso W.Y.W., YEUNG K.S., Ip J.K.J., Liu A.P.Y., Lee P.P.W., Chu W.Y., Chong C.Y., Ho M.H.K., Chan G.C.F., Lau Y.L. and Chung B.H.Y., The genetics of macrocephaly, autistic spectrum disorders and developmental delay in Chinese children. British Paediatric Neurology Association Annual Meeting, 11-13 January 2017, UK [Poster Presentations], Developmental Medicine & Child Neurology. 2017, 59: 19-108. |
| YEUNG K.S., Chung B.H.Y., Choufani S., Mok M.Y.T., Wong W.L., MAK C.C.Y., Yang W., Lee P.P.W., Wong W.H.S., Chen Y.A., Grafodatskaya D., Wong W.S.R., Lau W.C.S., Chan D.T.M., Weksberg R., Lau Y.L. and Crispin J.C., Genome-Wide DNA Methylation Analysis of Chinese Patients with Systemic Lupus Erythematosus Identified Hypomethylation in Genes Related to the Type I Interferon Pathway, PLOS ONE. 2017, 12: e0169553. |
| YEUNG K.S., Chung B.H.Y., Choufani S., Mok M.Y.T., Wong W.L., MAK C.C.Y., Yang W., Lee P.P.W., Wong W.H.S., Chen Y.A., Grafodatskaya D., Wong R.M.S., Lau W.C.S., Chan T.M., Weksberg R. and Lau Y.L., Genome-wide DNA methylation analysis of Chinese patients with systemic lupus erythematosus identified hypomethylation in genes to type I interferon pathway [PONE-D-16-30852R1], accepted, PLOS One. 2017. |
| Researcher : Lee SL |
| Project Title: | Where for Rare |
| Investigator(s): | Lee SL, Chung BHY, Chau SKC, Cheung YF, Tao QV, Tso WYW, Yung AWY, Wong RMS, Lee DCW, Wong WHS |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | The Society for the Relief of Disabled Children |
| Start Date: | 01/2017 |
| List of Research Outputs |
| Chau S.K.C., Yung A.W.Y. and Lee S.L., Long-Term Management for Ventilator-Assisted Children in Hong Kong: 2 Decades' Experience, Respiratory Care. 2017, 62: 54-64. |
| Chu W.Y., LEUNG K.C., Mak A.S.L., Chiu T.A., MAK C.C.Y., Mok T.K.G., Tang W.F., Chan Y.K., Tang M.H.Y., Lau E.T.K., So K.W., Tao Q.V., Fung C.W., Wong V.C.N., Lee S.L., Marshall C., Scherer S., Kan S.Y.A. and Chung B.H.Y., Use of clinical chromosomal microarray in Hong Kong Chinese patients with autism spectrum disorder - Implication of a copy number variation involving DPP10, Asian Society for Pediatric Research (ASPR) and Faculty of Medicine Ramathibodi Hospital 2016, Thailand, Bangkok, 10-12 November 2016. |
| Chung B.H.Y., Mak S.L., Chiu T.A., LEUNG K.C., MAK C.C.Y., Chu W.Y., Mok T.K.G., Chan Y.K., Kan S.Y.A., Tang M.H.Y., Lau E.T.K., Fung C.W. and Lee S.L., Use of chromosomal microarray in Hong Kong patients with autism spectrum disorder - implication of a copy number variation involving DPP10, ASHG 2016, Vancouver, Canada, 18-22 October 2016. |
| LEUNG K.C., Ying D., MAK C.C.Y., Chen X.Y., Xu W., YEUNG K.S., Wong W.L., Chu W.Y., Mok T.K.G., Chau S.K.C., McLuskey J., Ong W.P.T., Leong H.Y., Chan Y.K., Yang W., Chen J.H., Li A.M., Sham P.C., Lau Y.L., Chung B.H.Y. and Lee S.L., CFTR founder mutation causes protein trafficking defects in Chinese patients with cystic fibrosis , Molecular Genetics & Genomic Medicine. 2016. |
| LEUNG K.C., Ying D., MAK C.C.Y., Chen X.Y., Xu W., YEUNG K.S., Chu W.Y., Mok T.K.G., Chau S.K.C., McLuskey J., Ong W.P.T., Leong H.Y., Chan Y.K., Yang W., Chen J.H., Li A.M., Lau Y.L., Lee S.L. and Chung B.H.Y., Identification of a CFTR founder mutations, c.3068T>G:p.I1023R, which causes protein trafficking defects in Chinese patients with cystic fibrosis, Asian Society for Pediatric Research (ASPR) and Faculty of Medicine Ramathibodi Hospital 2016, Thailand, Bangkok, 10-12 November 2016. |
| Lee S.L., O'Callaghan C., Lau Y.L. and Lee D.C.W., Functional analysis and evaluation of ultrastructure of respiratory cilia in healthy Chinese children in Hong Kong, Health Research Symposium (HRS)2017, Hong Kong, 16 June 2017. |
| Lee S.L., Lau Y.L., Wong W.H.S. and Tian L., Prevalence of and Risk Factors for Childhood Asthma, Rhinitis, and Eczema in Hong Kong: Proposal for a Cross-Sectional Survey, JMIR Research Protocols. 2017, 6: e106. |
| TSANG H.Y., LEUNG K.C., MAK C.C.Y., Miu X., Lee S.L., Chan G.C.F., Yung A.W.Y. and Chung B.H.Y., Genetic diagnosis of drug-resistant epilepsy by whole exome sequencing and chromosomal array in Hong Kong, Hong Kong College of Paediatricians, 4th Annual Scientific Meeting cum 5th Hong Kong-Guangdong-Shanghai-Chongqing Paediatric Exchange Meeting, HK, 3-4 December 2016. |
| TSANG H.Y., LEUNG K.C., MAK C.C.Y., Chu W.Y., Mu X., Lee S.L., Chan G.C.F., Yung A.W.Y. and Chung B.H.Y., Genetic diagnosis of early onset epilepsy by whole exome sequencing and chromosomal array in Hong Kong, Asian Society for Pediatric Research (ASPR) and Faculty of Medicine Ramathibodi Hospital 2016, Thailand, Bangkok, 10-12 November 2016. |
| Researcher : Leung KCP |
| List of Research Outputs |
| van Damme T., Gardeitchik T., Mohamed M., Guerrero-Castillo S., Freisinger P., Guillemyn B., Kariminejad A., Dalloyaux D., van Kraaij S., Lefeber D.J., Syx D., Steyaert W., DeRycke R., Hoischen A., Kamsteeg E.J., Wong S.Y., van Scherpenzeel M., Jamali P., Brandt P., Nijtmans L., Korenke G.C., Chung B.H.Y., MAK C.C.Y., Hausser I., Kornak U., Fischer-Zirnsak B., Strom T.M., Meitinger T., Alanay Y., Utine G.E., Leung K.C.P., Ghaderi-Sohi S., Coucke P., Symoens S., De Paepe A., Thiel C., Haack T.B., Malfait F., Morava E., Callewaert B. and Wevers R.A., Mutations in ATP6V1E1 or ATP6V1A cause autosomal-recessive cutis laxa, The American Journal of Human Genetics. 2017, 100: 2. |
| Researcher : Li CB |
| Project Title: | The role of c-Myc in anti-mycobaterial responses: from bacterial killing to T cell activation |
| Investigator(s): | Li CB, Chan GCF |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 02/2014 |
| Project Title: | A role for interleukin-17A in influenza virus induced immune responses and viral replication |
| Investigator(s): | Li CB |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2016 |
| Researcher : Li L |
| List of Research Outputs |
| Fu K.W., Ho F.K.W., Rao N., Fan F.J., Li L., Lee T.M.C., Chan H.S.S., Yung A.W.Y., Young Y.M.E. and Ip P., Parental restriction reduces the harmful effects of in-bedroom electronic devices, Archives of Disease in Childhood. 2017, archdischild-2017-312639. |
| Researcher : Li MH |
| List of Research Outputs |
| Chow C.B., Wong W.H.S., Leung W.C., Tang M.H.Y., Chan E.K.L., Or C.K.L., Li M.H., Ho K.W., Lo D. and Ip P., Effectiveness of Internet-based injury prevention program in enhancing mother’s knowledge on child safety, JMIR Res Protoc. 2016. |
| Ip P., Chim D., Chan E.K.L., Li M.H., Ho K.W., Voorhees B.W.V., Tiwari A., Tsang A.M.C., Chan C.W.L., Ho S.P., Tso W.Y.W. and Wong W.H.S., Effectiveness of a Culturally Attuned Internet-based Depression Prevention Program for Chinese Adolescents: A Randomized Controlled Trial, Depression and Anxiety. 2016. |
| Researcher : Liu APY |
| Project Title: | Copy-number variations in Chinese patients with conotruncal defects |
| Investigator(s): | Liu APY, Wong WL, Chung BHY |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2013 |
| Project Title: | Immunogenicity and immunomodulatory activitiy of induced pluripotent stem cells-derived cardiomyocytes from human mesenchymal stem cells |
| Investigator(s): | Liu APY, Poon NYE, Boheler KR, Chan GCF |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2014 |
| Project Title: | SIOPEL Spring Meeting 2017; Treatment Outcome of Paediatric Hepatoblastoma in Hong Kong |
| Investigator(s): | Liu APY |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2017 |
| Completion Date: | 04/2017 |
| List of Research Outputs |
| Lee B.W., Liu A.P.Y., Leung T.F., Fong S.L., Franck T., Oh H.M.L., Chan P.C., Rombo L., Tan N.C., Rouzier R., De Simoni S., Suryakiran P., Hezareh M., Folschweiller N., Thomas F. and Struyf F., Immunological Superiority Of 2-dose As04-hpv-16/18 Vaccine Schedule Versus 2-dose And 3-dose Schedules Of 4vhpv At Month36; A Randomized, Multicentre Trial, Asia-Oceania Research Organisation in Genital Infection and Neoplasia. 2016. |
| Liu A.P.Y. and Cheuk K.L.D., Disease-modifying treatments for primary autoimmune haemolytic anaemia, In: The Cochrane Collaboration, Cochrane Database of Systematic Reviews: Protocols. Chichester, UK, John Wiley & Sons, Ltd, 2017. |
| Liu A.P.Y., Leung Y.Y., Kwok J.S.Y., Chiang A.K.S., Ha S.Y., Lee P.P.W., Cheuk D.K.L. and Chan G.C.F., HAPLOIDENTICAL HEMATOPOIETIC STEM CELL TRANSPLANTATION FOR RELAPSED/REFRACTORY OR METASTATIC PEDIATRIC SOLID TUMORS, SIOP Asia 2017. |
| Liu A.P.Y., Ip J.J.K., Leung A.W.K., Luk C.W., Li C.H., Ho K.K.H., Lo C.L.R., Chan E.K.W., Chan A.C.Y., Chung H.Y. and Chiang A.K.S., Outcome of Paediatric Hepatoblastoma in Hong Kong, SIOPEL Spring Meeting 2017. |
| MAK C.C.Y., Chow P.C., Liu A.P.Y., Chan Y.K., Chu W.Y., Mok T.K.G., LEUNG K.C., YEUNG K.S., Chau A.K.T., Lowther C., Scherer S.W., Marshall C.R., Bassett A.S. and Chung B.H.Y., De novo large rare copy-number variations contribute to conotruncal heart disease in Chinese patients, npj Genomic Medicine. 2016, 1: 16033. |
| Tso W.Y.W., YEUNG K.S., Ip J.K.J., Liu A.P.Y., Lee P.P.W., Chu W.Y., Chong C.Y., Ho M.H.K., Chan G.C.F., Lau Y.L. and Chung B.H.Y., The genetics of macrocephaly, autistic spectrum disorders and developmental delay in Chinese children. British Paediatric Neurology Association Annual Meeting, 11-13 January 2017, UK [Poster Presentations], Developmental Medicine & Child Neurology. 2017, 59: 19-108. |
| Wong R.W.C., Liu A.P.Y., Wan E.H.Y. and Chan A.O.K., Vaginal paraganglioma as a manifestation of germline SDHB mutation: Case report with genetic findings and review of the literature, International Congress of Gynecologic and Obstetric Pathology 2016. |
| Researcher : Liu Y |
| List of Research Outputs |
| CHEN Q., Liu Y., Lv A., NI K., Xiang Z., WEN K. and Tu W., Influenza virus infection exacerbates experimental autoimmune encephalomyelitis disease by promoting type I T cells infiltration into central nervous system, Journal of Autoimmunity. 2017, 77: 1-10. |
| Liu Y., Zheng J., Liu Y., WEN L., Huang L., Xiang Z., Lam K.T., Lv A., Mao H., Lau Y.L. and Tu W., Uncompromised NK cell activation is essential for virus-specific CTL activity during acute influenza virus infection, Cellular & Molecular Immunology. 2017. |
| Mao H., Liu Y., Sia S.F., Peiris J.S.M., Lau Y.L. and Tu W., Avian influenza virus directly infects human natural killer cells and inhibits cell activity, Virologica Sinica. 2017, 32(2): 122-9. |
| Researcher : Low LCK |
| Project Title: | 12th Asia Pacific Congress of Paediatrics and 2nd Asia Pacific Congress of Paediatric Nursing The Role of Nutritional Intake and Total Energy Expenditure on Early Growth of Babies Born with Intrauterine Growth Retardation |
| Investigator(s): | Low CKL |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2006 |
| Researcher : MAK CCY |
| List of Research Outputs |
| Chu W.Y., LEUNG K.C., Mak A.S.L., Chiu T.A., MAK C.C.Y., Mok T.K.G., Tang W.F., Chan Y.K., Tang M.H.Y., Lau E.T.K., So K.W., Tao Q.V., Fung C.W., Wong V.C.N., Lee S.L., Marshall C., Scherer S., Kan S.Y.A. and Chung B.H.Y., Use of clinical chromosomal microarray in Hong Kong Chinese patients with autism spectrum disorder - Implication of a copy number variation involving DPP10, Asian Society for Pediatric Research (ASPR) and Faculty of Medicine Ramathibodi Hospital 2016, Thailand, Bangkok, 10-12 November 2016. |
| Chung B.H.Y., YEUNG K.S., Tso W.Y.W., Ying D., Ip J.K.J., Chu W.Y., LEUNG K.C. and MAK C.C.Y., Exome sequencing of a Chinese patient cohort with ID/ASD and macrocephaly/megalencephaly: Identification of a patient with biallelic PTEN mutations and others with germline/ post-zygotic mutations in PIK3C-AKT-mTOR pathway, 17th Manchester Dysmorphology Conference, Manchester, UK, 7-10 November 2016. |
| Chung B.H.Y., Mak S.L., Chiu T.A., LEUNG K.C., MAK C.C.Y., Chu W.Y., Mok T.K.G., Chan Y.K., Kan S.Y.A., Tang M.H.Y., Lau E.T.K., Fung C.W. and Lee S.L., Use of chromosomal microarray in Hong Kong patients with autism spectrum disorder - implication of a copy number variation involving DPP10, ASHG 2016, Vancouver, Canada, 18-22 October 2016. |
| Kruszka P., Addissie Y.A., McGinn D.E., Porras A.R., Biggs E., Share M., Crowley T.B., Chung B.H.Y., Mok T.K.G., MAK C.C.Y., Muthukumarasamy P., Thong M.K., Siriseria N.D., Dissanayake V.H.W., Paththinige C.S., Prabodha L.B.L., Mishra R., Shotelersuk V., Ekure E.N., Sokunbi O.J., Kalu N., Ferreira C.R., Duncan J.M., Patil S.J., Jones K.L., Kaplan J.D., Abdul-Rahman O.A., Uwineza A., Mutesa L., Moresco A., Obregon M.G., Richieri-Costa A., Gil-da-Silva-Lopes V.L., Adeyemo A.A., Summar M., Zackai E.H., McDonald-McGinn D.M., Linguraru M.G. and Muenke M., 22q11.2 deletion syndrome in diverse populations, American Journal of Medical Genetics Part A. 2017, 173: 879-888. |
| LEUNG K.C., Ying D., MAK C.C.Y., Chen X.Y., Xu W., YEUNG K.S., Wong W.L., Chu W.Y., Mok T.K.G., Chau S.K.C., McLuskey J., Ong W.P.T., Leong H.Y., Chan Y.K., Yang W., Chen J.H., Li A.M., Sham P.C., Lau Y.L., Chung B.H.Y. and Lee S.L., CFTR founder mutation causes protein trafficking defects in Chinese patients with cystic fibrosis , Molecular Genetics & Genomic Medicine. 2016. |
| LEUNG K.C., Ying D., MAK C.C.Y., Chen X.Y., Xu W., YEUNG K.S., Chu W.Y., Mok T.K.G., Chau S.K.C., McLuskey J., Ong W.P.T., Leong H.Y., Chan Y.K., Yang W., Chen J.H., Li A.M., Lau Y.L., Lee S.L. and Chung B.H.Y., Identification of a CFTR founder mutations, c.3068T>G:p.I1023R, which causes protein trafficking defects in Chinese patients with cystic fibrosis, Asian Society for Pediatric Research (ASPR) and Faculty of Medicine Ramathibodi Hospital 2016, Thailand, Bangkok, 10-12 November 2016. |
| MAK C.C.Y., Chow P.C., Liu A.P.Y., Chan Y.K., Chu W.Y., Mok T.K.G., LEUNG K.C., YEUNG K.S., Chau A.K.T., Lowther C., Scherer S.W., Marshall C.R., Bassett A.S. and Chung B.H.Y., De novo large rare copy-number variations contribute to conotruncal heart disease in Chinese patients, npj Genomic Medicine. 2016, 1: 16033. |
| TSANG H.Y., LEUNG K.C., MAK C.C.Y., Miu X., Lee S.L., Chan G.C.F., Yung A.W.Y. and Chung B.H.Y., Genetic diagnosis of drug-resistant epilepsy by whole exome sequencing and chromosomal array in Hong Kong, Hong Kong College of Paediatricians, 4th Annual Scientific Meeting cum 5th Hong Kong-Guangdong-Shanghai-Chongqing Paediatric Exchange Meeting, HK, 3-4 December 2016. |
| TSANG H.Y., LEUNG K.C., MAK C.C.Y., Chu W.Y., Mu X., Lee S.L., Chan G.C.F., Yung A.W.Y. and Chung B.H.Y., Genetic diagnosis of early onset epilepsy by whole exome sequencing and chromosomal array in Hong Kong, Asian Society for Pediatric Research (ASPR) and Faculty of Medicine Ramathibodi Hospital 2016, Thailand, Bangkok, 10-12 November 2016. |
| YEUNG K.S., Chung B.H.Y., Choufani S., Mok M.Y.T., Wong W.L., MAK C.C.Y., Yang W., Lee P.P.W., Wong W.H.S., Chen Y.A., Grafodatskaya D., Wong W.S.R., Lau W.C.S., Chan D.T.M., Weksberg R., Lau Y.L. and Crispin J.C., Genome-Wide DNA Methylation Analysis of Chinese Patients with Systemic Lupus Erythematosus Identified Hypomethylation in Genes Related to the Type I Interferon Pathway, PLOS ONE. 2017, 12: e0169553. |
| YEUNG K.S., Chung B.H.Y., Choufani S., Mok M.Y.T., Wong W.L., MAK C.C.Y., Yang W., Lee P.P.W., Wong W.H.S., Chen Y.A., Grafodatskaya D., Wong R.M.S., Lau W.C.S., Chan T.M., Weksberg R. and Lau Y.L., Genome-wide DNA methylation analysis of Chinese patients with systemic lupus erythematosus identified hypomethylation in genes to type I interferon pathway [PONE-D-16-30852R1], accepted, PLOS One. 2017. |
| van Damme T., Gardenchik T., Mohamed M., Gucerrero-Castillo S., Freisinger P., Guillemyn B., Kariminejad A., Dalloyaux D., van Kraaij S., Lefeber D.J., Syx D., Steyaert W., De Rycke R., Hotschen A., Kamstccg E.J., Wong S.Y., van Scherpenzeei M., Jamali P., Brandt U., Nijtmans L., Korenke C., Chung B.H.Y., MAK C.C.Y., Hausser I., Kornak U., Fischer-Zirnsak B., Strom T.M., Meitinger T., Alanay Y., Utine G.E., Leung P.K.C., Ghadcri-Soli S., Coucke P., Symoens S., De Paepe A., Thiel C., Haack T.B., Malfair F., Morava E. and Callewaert B., Mutations in ATP6V1E1 or ATP6V1A cause AR cutis laxia, Asian Society for Pediatric Research (ASPR) and Faculty of Medicine Ramathibodi Hospital ASHG 2016, Thailand, Bangkok, 10-12 November 2016. |
| van Damme T., Gardeitchik T., Mohamed M., Guerrero-Castillo S., Freisinger P., Guillemyn B., Kariminejad A., Dalloyaux D., van Kraaij S., Lefeber D.J., Syx D., Steyaert W., DeRycke R., Hoischen A., Kamsteeg E.J., Wong S.Y., van Scherpenzeel M., Jamali P., Brandt P., Nijtmans L., Korenke G.C., Chung B.H.Y., MAK C.C.Y., Hausser I., Kornak U., Fischer-Zirnsak B., Strom T.M., Meitinger T., Alanay Y., Utine G.E., Leung K.C.P., Ghaderi-Sohi S., Coucke P., Symoens S., De Paepe A., Thiel C., Haack T.B., Malfait F., Morava E., Callewaert B. and Wevers R.A., Mutations in ATP6V1E1 or ATP6V1A cause autosomal-recessive cutis laxa, The American Journal of Human Genetics. 2017, 100: 2. |
| Researcher : Mak HS |
| List of Research Outputs |
| CHONG C.H., NG C.P., Mak H.S., Li Q., McAlonan G.M. and Chan S.Y., LRRC7 regulates neurite morphogenesis through mGluR5, Annual Meeting of Neuroscience 2016 (San Diego, USA). 2016. |
| Researcher : Man E |
| List of Research Outputs |
| Man E., Cheung P.T. and Cheung Y.F., Associations between arterial structure and function and serum levels of liver enzymes in obese adolescents, J Paediatr Child Health 2017. 2017. |
| Researcher : Man KCK |
| List of Research Outputs |
| LAU C.Y., Chan E.W., Cheung C.L., SING C.W., Man K.C.K., Lip G.Y.H., Siu D.C.W., Lam K.Y.J., Lee C.H.A. and Wong I.C.K., Association Between Dabigatran vs Warfarin and Risk of Osteoporotic Fractures Among Patients With Nonvalvular Atrial Fibrillation, JAMA. 2017, 317: 1151. |
| Man K.C.K., Best poster award, 32nd International Conference on Pharmacoepidemiology & Therapeutic Risk Management, August 25-28, 2016, Dublin, International Society for Pharmacoepidemiology. 2016. |
| Man K.C.K., Lai E.C., Su C.C., Kubota K., Kimura S., Stang P., Schuemie M., Ryan P., Kao Yang Y.H., Zhang Y., Setoguchi S. and Wong I.C.K., Epidemiology in Asian Pharmacoepidemiology Network (AsPEN): study in Surveillance of Health Care in Asian Network (SCAN), 32nd International Conference on Pharmacoepidemiology and Therapeutic Risk Management, August 25-28, 2016, Dublin. 2016. |
| Man K.C.K., Lai E.C., Su C.C., Kubota K., Kimura S., Stang P., Schuemie M., Ryan P., Kao Yang Y.H., Zhang Y., Setoguchi S. and Wong I.C.K., Incidence and medical resource utilization for cardiovascular events in Asia, 32nd International Conference on Pharmacoepidemiology and Therapeutic Risk Management, August 25-28, 2016, Dublin. 2016. |
| Man K.C.K., Coghill D., Chan E.W., LAU C.Y., Hollis C., Liddle E., Banaschewski T., McCarthy S., Neubert A., Sayal K., Ip P. and Wong I.C.K., Methylphenidate and the risk of psychotic disorders and hallucinations in children and adolescents in a large health system, Translational Psychiatry. Nature Publishing Group, 2016, 6(11): e956. |
| Man K.C.K., Chan E.W., Ip P., Coghill D.R., Simonoff E., Chan P.K.L., LAU C.Y., Schuemie M.J., Sturkenboom M.C.J.M. and Wong I.C.K., Prenatal antidepressant use and risk of attention-deficit/hyperactivity disorder in offspring: population based cohort study, BMJ. 2017, j2350. |
| Roughead E.E., Chan E.W., Choi N.K., Griffiths J., Lee J., Kimura T., Kubota K., Lai E.C., Man K.C.K., Nguyen T.A., Ooba N., Park B.J., Sato T., Shin J.Y., Wang T.T., Wong I.C.K., Kao Yang Y.H. and Pratt N., Proton pump inhibitors and risk of Clostridium difficile infection: a multi-country study using sequence symmetry analysis., Expert Opinion On Drug Safety. 2016, 15(12): 1589-1595. |
| Researcher : Mao H |
| List of Research Outputs |
| Mao H., Liu Y., Sia S.F., Peiris J.S.M., Lau Y.L. and Tu W., Avian influenza virus directly infects human natural killer cells and inhibits cell activity, Virologica Sinica. 2017, 32(2): 122-9. |
| Researcher : Mok TKG |
| List of Research Outputs |
| Chiu T.A., Zhu L., Mok T.K.G., LEUNG K.C., Chow C.B. and Chung B.H.Y., Before and after – Nutritional transformation of dysmorphism in a case of Costello syndrome, European Journal of Medical Genetics. 2016, 59: 573-576. |
| Chu W.Y., LEUNG K.C., Mak A.S.L., Chiu T.A., MAK C.C.Y., Mok T.K.G., Tang W.F., Chan Y.K., Tang M.H.Y., Lau E.T.K., So K.W., Tao Q.V., Fung C.W., Wong V.C.N., Lee S.L., Marshall C., Scherer S., Kan S.Y.A. and Chung B.H.Y., Use of clinical chromosomal microarray in Hong Kong Chinese patients with autism spectrum disorder - Implication of a copy number variation involving DPP10, Asian Society for Pediatric Research (ASPR) and Faculty of Medicine Ramathibodi Hospital 2016, Thailand, Bangkok, 10-12 November 2016. |
| Chung B.H.Y., Mak S.L., Chiu T.A., LEUNG K.C., MAK C.C.Y., Chu W.Y., Mok T.K.G., Chan Y.K., Kan S.Y.A., Tang M.H.Y., Lau E.T.K., Fung C.W. and Lee S.L., Use of chromosomal microarray in Hong Kong patients with autism spectrum disorder - implication of a copy number variation involving DPP10, ASHG 2016, Vancouver, Canada, 18-22 October 2016. |
| Kruszka P., Addissie Y.A., McGinn D.E., Porras A.R., Biggs E., Share M., Crowley T.B., Chung B.H.Y., Mok T.K.G., MAK C.C.Y., Muthukumarasamy P., Thong M.K., Siriseria N.D., Dissanayake V.H.W., Paththinige C.S., Prabodha L.B.L., Mishra R., Shotelersuk V., Ekure E.N., Sokunbi O.J., Kalu N., Ferreira C.R., Duncan J.M., Patil S.J., Jones K.L., Kaplan J.D., Abdul-Rahman O.A., Uwineza A., Mutesa L., Moresco A., Obregon M.G., Richieri-Costa A., Gil-da-Silva-Lopes V.L., Adeyemo A.A., Summar M., Zackai E.H., McDonald-McGinn D.M., Linguraru M.G. and Muenke M., 22q11.2 deletion syndrome in diverse populations, American Journal of Medical Genetics Part A. 2017, 173: 879-888. |
| Kruszka P., Porras A.R., Sobering A.K., Ikolo F.A., Qua S.L., Shotelersuk V., Chung B.H.Y., Mok T.K.G., Uwineza A., Mutesa L., Moresco A., Obregon M.G., Sokunbi O.J., Kalu N., Joseph D.A., Ikebudu D., Ugwu C.E., Okoromah C.A.N., Addissie Y.A., Pardo K.L., Brough J.J., Lee N.C., Girisha K.M., Patil S.J., Ng I.S.L., Mim B.C.W., Jamuar S.S., Tibrewal S., Wallang B., Ganesh S., Sirisena N.D., Dissanayake V.H.W., Paththinige C.S., Prabodha L.B.L., Richieri-Costa A., Muthukumarasamy P., Thong M.K., Jones K.L., Abdul-Rahman O.A., Ekure E.N., Adeyemo A.A., Summar M., Linguraru M.G. and Muenke M., Down syndrome in diverse populations, American Journal of Medical Genetics Part A. 2017, 173: 42-53. |
| LEUNG K.C., Ying D., MAK C.C.Y., Chen X.Y., Xu W., YEUNG K.S., Wong W.L., Chu W.Y., Mok T.K.G., Chau S.K.C., McLuskey J., Ong W.P.T., Leong H.Y., Chan Y.K., Yang W., Chen J.H., Li A.M., Sham P.C., Lau Y.L., Chung B.H.Y. and Lee S.L., CFTR founder mutation causes protein trafficking defects in Chinese patients with cystic fibrosis , Molecular Genetics & Genomic Medicine. 2016. |
| LEUNG K.C., Ying D., MAK C.C.Y., Chen X.Y., Xu W., YEUNG K.S., Chu W.Y., Mok T.K.G., Chau S.K.C., McLuskey J., Ong W.P.T., Leong H.Y., Chan Y.K., Yang W., Chen J.H., Li A.M., Lau Y.L., Lee S.L. and Chung B.H.Y., Identification of a CFTR founder mutations, c.3068T>G:p.I1023R, which causes protein trafficking defects in Chinese patients with cystic fibrosis, Asian Society for Pediatric Research (ASPR) and Faculty of Medicine Ramathibodi Hospital 2016, Thailand, Bangkok, 10-12 November 2016. |
| MAK C.C.Y., Chow P.C., Liu A.P.Y., Chan Y.K., Chu W.Y., Mok T.K.G., LEUNG K.C., YEUNG K.S., Chau A.K.T., Lowther C., Scherer S.W., Marshall C.R., Bassett A.S. and Chung B.H.Y., De novo large rare copy-number variations contribute to conotruncal heart disease in Chinese patients, npj Genomic Medicine. 2016, 1: 16033. |
| Mok T.K.G., Fleischer N., Luk H.M. and Chung B.H.Y., Computer-aided facial recognition of Chinese individuals with Angelman Syndrome in Hong Kong, Asian Society for Pediatric Research (ASPR) and Faculty of Medicine Ramathibodi Hospital 2016, Thailand, Bangkok, 10-12 November 2016. |
| Mok T.K.G., Chu W.Y., Luk H.M. and Chung B.H.Y., Computer-aided facial recognition of Chinese individuals with Angelman syndrome in Hong Kong, Hong Kong College of Paediatricians, 4th Annual Scientific Meeting cum 5th Hong Kong-Guangdong-Shanghai-Chongqing Paediatric Exchange Meeting, HK, 3-4 December 2016. |
| Researcher : Mu X |
| List of Research Outputs |
| TSANG H.Y., LEUNG K.C., MAK C.C.Y., Chu W.Y., Mu X., Lee S.L., Chan G.C.F., Yung A.W.Y. and Chung B.H.Y., Genetic diagnosis of early onset epilepsy by whole exome sequencing and chromosomal array in Hong Kong, Asian Society for Pediatric Research (ASPR) and Faculty of Medicine Ramathibodi Hospital 2016, Thailand, Bangkok, 10-12 November 2016. |
| Researcher : NG CP |
| List of Research Outputs |
| CHONG C.H., NG C.P., Mak H.S., Li Q., McAlonan G.M. and Chan S.Y., LRRC7 regulates neurite morphogenesis through mGluR5, Annual Meeting of Neuroscience 2016 (San Diego, USA). 2016. |
| Researcher : NI K |
| List of Research Outputs |
| CHEN Q., Liu Y., Lv A., NI K., Xiang Z., WEN K. and Tu W., Influenza virus infection exacerbates experimental autoimmune encephalomyelitis disease by promoting type I T cells infiltration into central nervous system, Journal of Autoimmunity. 2017, 77: 1-10. |
| Researcher : See WSQ |
| List of Research Outputs |
| See W.S.Q., Cheuk K.L.D., To K.F., Ip P.C.P., Chiang A.K.S., Ha S.Y. and Chan G.C.F., Congenital intestinal fibrosarcoma with rapid recurrence requiring adjuvant chemotherapy, Pediatrics International. 2017. |
| See W.S.Q., Chang K.O., Cheuk K.L.D., Leung Y.R., Chan G.C.F., Chan S.C. and Ha S.Y., Inhibitor development after liver transplantation in congenital factor VII deficiency, Haemophilia. 2016, 22(5): e417-422. |
| Researcher : So KW |
| List of Research Outputs |
| Chu W.Y., LEUNG K.C., Mak A.S.L., Chiu T.A., MAK C.C.Y., Mok T.K.G., Tang W.F., Chan Y.K., Tang M.H.Y., Lau E.T.K., So K.W., Tao Q.V., Fung C.W., Wong V.C.N., Lee S.L., Marshall C., Scherer S., Kan S.Y.A. and Chung B.H.Y., Use of clinical chromosomal microarray in Hong Kong Chinese patients with autism spectrum disorder - Implication of a copy number variation involving DPP10, Asian Society for Pediatric Research (ASPR) and Faculty of Medicine Ramathibodi Hospital 2016, Thailand, Bangkok, 10-12 November 2016. |
| Researcher : TSANG HY |
| List of Research Outputs |
| TSANG H.Y., LEUNG K.C., MAK C.C.Y., Miu X., Lee S.L., Chan G.C.F., Yung A.W.Y. and Chung B.H.Y., Genetic diagnosis of drug-resistant epilepsy by whole exome sequencing and chromosomal array in Hong Kong, Hong Kong College of Paediatricians, 4th Annual Scientific Meeting cum 5th Hong Kong-Guangdong-Shanghai-Chongqing Paediatric Exchange Meeting, HK, 3-4 December 2016. |
| TSANG H.Y., LEUNG K.C., MAK C.C.Y., Chu W.Y., Mu X., Lee S.L., Chan G.C.F., Yung A.W.Y. and Chung B.H.Y., Genetic diagnosis of early onset epilepsy by whole exome sequencing and chromosomal array in Hong Kong, Asian Society for Pediatric Research (ASPR) and Faculty of Medicine Ramathibodi Hospital 2016, Thailand, Bangkok, 10-12 November 2016. |
| Researcher : Tan TY |
| List of Research Outputs |
| Chu W.Y., Chu S.P.W., Mok W.K.Y., Tan T.Y. and Chung B.H.Y., Insights on sensitive language use in the Hong Kong healthcare setting: perceptions of parents and caregivers of patients with Down syndrome, Hong Kong Journal of Paediatrics. 2017, 22: 26-33. |
| Researcher : Tao QV |
| List of Research Outputs |
| Chu W.Y., LEUNG K.C., Mak A.S.L., Chiu T.A., MAK C.C.Y., Mok T.K.G., Tang W.F., Chan Y.K., Tang M.H.Y., Lau E.T.K., So K.W., Tao Q.V., Fung C.W., Wong V.C.N., Lee S.L., Marshall C., Scherer S., Kan S.Y.A. and Chung B.H.Y., Use of clinical chromosomal microarray in Hong Kong Chinese patients with autism spectrum disorder - Implication of a copy number variation involving DPP10, Asian Society for Pediatric Research (ASPR) and Faculty of Medicine Ramathibodi Hospital 2016, Thailand, Bangkok, 10-12 November 2016. |
| Researcher : Tsang AMC |
| List of Research Outputs |
| Ip P., Chim D., Chan E.K.L., Li M.H., Ho K.W., Voorhees B.W.V., Tiwari A., Tsang A.M.C., Chan C.W.L., Ho S.P., Tso W.Y.W. and Wong W.H.S., Effectiveness of a Culturally Attuned Internet-based Depression Prevention Program for Chinese Adolescents: A Randomized Controlled Trial, Depression and Anxiety. 2016. |
| Lo C.K.M., Tung T.S., Chan L.K., Yip P.S.F., Lau J.T.F., Wong W.H.S., Wong R.S.M., Tsang A.M.C., Tsang H.Y.H., Tso W.Y.W. and Ip P., Risk factors for child physical abuse and neglect among Chinese young mothers, Child Abuse & Neglect. 2017, 67: 193-206. |
| Researcher : Tsang HYH |
| List of Research Outputs |
| Lo C.K.M., Tung T.S., Chan L.K., Yip P.S.F., Lau J.T.F., Wong W.H.S., Wong R.S.M., Tsang A.M.C., Tsang H.Y.H., Tso W.Y.W. and Ip P., Risk factors for child physical abuse and neglect among Chinese young mothers, Child Abuse & Neglect. 2017, 67: 193-206. |
| Researcher : Tso WWY |
| Project Title: | The use of diffusion kurtosis imaging (DKI) to quantify brain microstructure alteration as predictor for neurocognitive and functional outcomes in childhood intracranial germinoma survivors |
| Investigator(s): | Tso WYW, Lee TMC, Fong DYT, Chan GCF, Khong PL, Hui SK |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2016 |
| Project Title: | The structural and functional brain connectivity in children with attention-deficit hyperactivity disorders: relationship with disease severity and Methylphenidate treatment |
| Investigator(s): | Tso WYW, Ip P, Khong PL, Vardhanabhuti V, Hui SK |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2017 |
| List of Research Outputs |
| Researcher : Tso WYW |
| Project Title: | The use of diffusion kurtosis imaging (DKI) to quantify brain microstructure alteration as predictor for neurocognitive and functional outcomes in childhood intracranial germinoma survivors |
| Investigator(s): | Tso WYW, Lee TMC, Fong DYT, Chan GCF, Khong PL, Hui SK |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2016 |
| Project Title: | The structural and functional brain connectivity in children with attention-deficit hyperactivity disorders: relationship with disease severity and Methylphenidate treatment |
| Investigator(s): | Tso WYW, Ip P, Khong PL, Vardhanabhuti V, Hui SK |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2017 |
| List of Research Outputs |
| Chung B.H.Y., YEUNG K.S., Tso W.Y.W., Ying D., Ip J.K.J., Chu W.Y., LEUNG K.C. and MAK C.C.Y., Exome sequencing of a Chinese patient cohort with ID/ASD and macrocephaly/megalencephaly: Identification of a patient with biallelic PTEN mutations and others with germline/ post-zygotic mutations in PIK3C-AKT-mTOR pathway, 17th Manchester Dysmorphology Conference, Manchester, UK, 7-10 November 2016. |
| Ip P., Chim D., Chan E.K.L., Li M.H., Ho K.W., Voorhees B.W.V., Tiwari A., Tsang A.M.C., Chan C.W.L., Ho S.P., Tso W.Y.W. and Wong W.H.S., Effectiveness of a Culturally Attuned Internet-based Depression Prevention Program for Chinese Adolescents: A Randomized Controlled Trial, Depression and Anxiety. 2016. |
| Lo C.K.M., Tung T.S., Chan L.K., Yip P.S.F., Lau J.T.F., Wong W.H.S., Wong R.S.M., Tsang A.M.C., Tsang H.Y.H., Tso W.Y.W. and Ip P., Risk factors for child physical abuse and neglect among Chinese young mothers, Child Abuse & Neglect. 2017, 67: 193-206. |
| Tso W.Y.W., YEUNG K.S., Ip J.K.J., Liu A.P.Y., Lee P.P.W., Chu W.Y., Chong C.Y., Ho M.H.K., Chan G.C.F., Lau Y.L. and Chung B.H.Y., The genetics of macrocephaly, autistic spectrum disorders and developmental delay in Chinese children. British Paediatric Neurology Association Annual Meeting, 11-13 January 2017, UK [Poster Presentations], Developmental Medicine & Child Neurology. 2017, 59: 19-108. |
| Researcher : Tu W |
| Project Title: | Humanized mouse as a model to study the antiviral activity of human gammadelta-T cells against human and avian influenza A viruses in vivo |
| Investigator(s): | Tu W, Lau YL, Peiris JSM, Law HKW |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 08/2007 |
| Project Title: | Induction of tolerance by alloantigen-specific regulatory T cells in humanized mice and non-human primates |
| Investigator(s): | Tu W, Lau YL, Liu Y |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2012 |
| Project Title: | Role of human gammadelta-T cells in the generation of influenza virus-specific antibody |
| Investigator(s): | Tu W, Lau YL, Liu Y |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2013 |
| Completion Date: | 10/2016 |
| Project Title: | Antiviral Activity of Human γδ-T cells against Enterovirus 71 |
| Investigator(s): | Tu W, Lau YL, Liu Y, Zheng J |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 01/2014 |
| Completion Date: | 03/2017 |
| Project Title: | Human gammadelta-T cell-mediated virus-specific immune regulation during influenza virus infection |
| Investigator(s): | Tu W, Lau YL, Liu Y, Zheng J |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Role of costimulatory molecule CD137 in the antiviral activity of human gammadelta-T cells against influenza virus |
| Investigator(s): | Tu W, Peiris JSM |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2016 |
| List of Research Outputs |
| CHEN Q., Liu Y., Lv A., NI K., Xiang Z., WEN K. and Tu W., Influenza virus infection exacerbates experimental autoimmune encephalomyelitis disease by promoting type I T cells infiltration into central nervous system, Journal of Autoimmunity. 2017, 77: 1-10. |
| Diao L.H., Li G.G., Zhu Y.C., Tu W., HUANG C., Lian R.C., Chen X., Li Y.Y., Zhang T., Huang Y. and Zeng Y., Human chorionic gonadotropin potentially affects pregnancy outcome in women with recurrent implantation failure by regulating the homing preference of regulatory T cells, American Journal of Reproductive Immunology. 2017, 77: e12618. |
| Liu Y., Zheng J., Liu Y., WEN L., Huang L., Xiang Z., Lam K.T., Lv A., Mao H., Lau Y.L. and Tu W., Uncompromised NK cell activation is essential for virus-specific CTL activity during acute influenza virus infection, Cellular & Molecular Immunology. 2017. |
| Mao H., Liu Y., Sia S.F., Peiris J.S.M., Lau Y.L. and Tu W., Avian influenza virus directly infects human natural killer cells and inhibits cell activity, Virologica Sinica. 2017, 32(2): 122-9. |
| Teng O., Chen S.T., Hsu T.L., Sia S.F., Cole S.L., Doak S.A., Hsu T.Y., Zheng J.T., Tu W., Bruzzone R., Peiris J.S.M., Hsieh S.A.L. and Yen H., CLEC5A-mediated enhancement of the inflammatory response in myeloid cells contributes to influenza pathogenicity in vivo. , Journal of Virology. 2017, 91(1): e01813-6. |
| Tu W. and Zheng J., Application of Humanized Mice in Immunological Research, In: Maria Cristina Cuturi and Ignacio Anegon , Suppression and Regulation of Immune Responses: Methods and Protocols, Volume II, Methods in Molecular Biology. New York, Springer Science+Business Media, 2016, 1371: 157-176. |
| Researcher : Tung TS |
| List of Research Outputs |
| Lo C.K.M., Tung T.S., Chan L.K., Yip P.S.F., Lau J.T.F., Wong W.H.S., Wong R.S.M., Tsang A.M.C., Tsang H.Y.H., Tso W.Y.W. and Ip P., Risk factors for child physical abuse and neglect among Chinese young mothers, Child Abuse & Neglect. 2017, 67: 193-206. |
| Researcher : WANG T |
| List of Research Outputs |
| Morris D.L., Sheng Y., Zhang Y., WANG Y., Zhu Z., Tombleson P., Chen L., Cunninghame Graham D.S., Bentham J., Roberts A.L., CHEN R., Zuo X., WANG T., Wen L., Yang C., Liu L., Yang L., Li F., Huang Y., Yin X., Yang S., Rönnblom L., Fürnrohr B.G., Voll R.E., Schett G., Costedoat-Chalumeau N., Gaffney P.M., Lau Y.L., Zhang X X., Yang W., Cui Y. and Vyse T.J., Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus., Nature Genetics. 2016, 48: 940–946. |
| WANG Y., GUO M., WANG T., Zhang Y., Yang J., Lau Y.L. and Yang W., Functional Properties of Genomic Region Associated with Multiple Traits in Genome-Wide Association Studies, The American Society of Human Genetics 2016. |
| Researcher : WANG Y |
| List of Research Outputs |
| Morris D.L., Sheng Y., Zhang Y., WANG Y., Zhu Z., Tombleson P., Chen L., Cunninghame Graham D.S., Bentham J., Roberts A.L., CHEN R., Zuo X., WANG T., Wen L., Yang C., Liu L., Yang L., Li F., Huang Y., Yin X., Yang S., Rönnblom L., Fürnrohr B.G., Voll R.E., Schett G., Costedoat-Chalumeau N., Gaffney P.M., Lau Y.L., Zhang X X., Yang W., Cui Y. and Vyse T.J., Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus., Nature Genetics. 2016, 48: 940–946. |
| WANG Y., GUO M., WANG T., Zhang Y., Yang J., Lau Y.L. and Yang W., Functional Properties of Genomic Region Associated with Multiple Traits in Genome-Wide Association Studies, The American Society of Human Genetics 2016. |
| Researcher : WEN K |
| List of Research Outputs |
| CHEN Q., Liu Y., Lv A., NI K., Xiang Z., WEN K. and Tu W., Influenza virus infection exacerbates experimental autoimmune encephalomyelitis disease by promoting type I T cells infiltration into central nervous system, Journal of Autoimmunity. 2017, 77: 1-10. |
| Researcher : WEN L |
| List of Research Outputs |
| Liu Y., Zheng J., Liu Y., WEN L., Huang L., Xiang Z., Lam K.T., Lv A., Mao H., Lau Y.L. and Tu W., Uncompromised NK cell activation is essential for virus-specific CTL activity during acute influenza virus infection, Cellular & Molecular Immunology. 2017. |
| Researcher : WONG OT |
| List of Research Outputs |
| Tse G., Liu T., Li K.H., Laxton V., WONG O.T., Chan Y.W., Keung W.W.Y., Chan C.W.Y. and Li R.A., Tachycardia-bradycardia syndrome: Electrophysiological mechanisms and future therapeutic approaches (Review), International Journal of Molecular Medicine. 2017. |
| Researcher : Wong CNV |
| Project Title: | Rett Syndrome :Systematic screening of MECP2 in children with autistic traits and or unexplained mental retardation/ encephalopathy to define the spectrum of Rett Syndrome phenotypes resulting from mutations in MECP2 |
| Investigator(s): | Wong CNV |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2006 |
| Project Title: | A study of copy number variations (CNVs) of genes NRXN1, GRIN2A, GRIN2B and PCDH19 associated with synaptic function in Chinese children with infantile epileptic encephalopathies |
| Investigator(s): | Wong CNV, Kwong KY, Fung CW |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2014 |
| Project Title: | Investigation of causal mutations by whole exome sequencing (WES) in Chinese children with infantile epileptic encephalopathy (IEE) |
| Investigator(s): | Wong CNV, Kwong KY, Fung CW |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2015 |
| Completion Date: | 04/2018 |
| List of Research Outputs |
| Chan H.S.S., Ho S.L.R., Chan A., Ip J., Wong S., Ng G., Lee H., Cheng S., Liu K.T., Lee C.N., Fung S., Cherk S., Chan T., Lam W., Shek T. and Wong C.N.V., Best Free Paper Award on the study ' Congenital myopathies are a group of phenotypically and genetically heterogeneous diseases', 29th Annual Scientific Meeting of the Hong Kong Neurological Society on 5th November 2016. 2016. |
| Fung C.W., Kwong K.Y. and Wong C.N.V., Gene panel analysis for nonsyndromic cryptogenic neonatal/infantile epileptic encephalopathy, Epilepsia Open. 2017, 2: 236-243. |
| Koene S., Hendriks J.C.M., Dirks I., de Boer L., de Vries M.C., Janssen M.C.H., Smuts I., Fung C.W., Wong C.N.V., de Coo I.R.F.M., Vill K., Stendel C., Klopstock T., Falk M.J., McCormick E.M., McFarland R., de Groot I.J.M. and Smeitink J.A.M., International Paediatric Mitochondrial Disease Scale, Journal of Inherited Metabolic Disease. 2016, 39: 705-712. |
| Researcher : Wong RMS |
| List of Research Outputs |
| YEUNG K.S., Chung B.H.Y., Choufani S., Mok M.Y.T., Wong W.L., MAK C.C.Y., Yang W., Lee P.P.W., Wong W.H.S., Chen Y.A., Grafodatskaya D., Wong R.M.S., Lau W.C.S., Chan T.M., Weksberg R. and Lau Y.L., Genome-wide DNA methylation analysis of Chinese patients with systemic lupus erythematosus identified hypomethylation in genes to type I interferon pathway [PONE-D-16-30852R1], accepted, PLOS One. 2017. |
| Researcher : Wong RSM |
| List of Research Outputs |
| Lo C.K.M., Tung T.S., Chan L.K., Yip P.S.F., Lau J.T.F., Wong W.H.S., Wong R.S.M., Tsang A.M.C., Tsang H.Y.H., Tso W.Y.W. and Ip P., Risk factors for child physical abuse and neglect among Chinese young mothers, Child Abuse & Neglect. 2017, 67: 193-206. |
| Researcher : Wong VCN |
| Project Title: | Rett Syndrome :Systematic screening of MECP2 in children with autistic traits and or unexplained mental retardation/ encephalopathy to define the spectrum of Rett Syndrome phenotypes resulting from mutations in MECP2 |
| Investigator(s): | Wong CNV |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2006 |
| Project Title: | A study of copy number variations (CNVs) of genes NRXN1, GRIN2A, GRIN2B and PCDH19 associated with synaptic function in Chinese children with infantile epileptic encephalopathies |
| Investigator(s): | Wong CNV, Kwong KY, Fung CW |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2014 |
| Project Title: | Investigation of causal mutations by whole exome sequencing (WES) in Chinese children with infantile epileptic encephalopathy (IEE) |
| Investigator(s): | Wong CNV, Kwong KY, Fung CW |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2015 |
| Completion Date: | 04/2018 |
| List of Research Outputs |
| Chu W.Y., LEUNG K.C., Mak A.S.L., Chiu T.A., MAK C.C.Y., Mok T.K.G., Tang W.F., Chan Y.K., Tang M.H.Y., Lau E.T.K., So K.W., Tao Q.V., Fung C.W., Wong V.C.N., Lee S.L., Marshall C., Scherer S., Kan S.Y.A. and Chung B.H.Y., Use of clinical chromosomal microarray in Hong Kong Chinese patients with autism spectrum disorder - Implication of a copy number variation involving DPP10, Asian Society for Pediatric Research (ASPR) and Faculty of Medicine Ramathibodi Hospital 2016, Thailand, Bangkok, 10-12 November 2016. |
| Researcher : Wong WHS |
| List of Research Outputs |
| Chow C.B., Wong W.H.S., Leung W.C., Tang M.H.Y., Chan E.K.L., Or C.K.L., Li M.H., Ho K.W., Lo D. and Ip P., Effectiveness of Internet-based injury prevention program in enhancing mother’s knowledge on child safety, JMIR Res Protoc. 2016. |
| Ip P., Chim D., Chan E.K.L., Li M.H., Ho K.W., Voorhees B.W.V., Tiwari A., Tsang A.M.C., Chan C.W.L., Ho S.P., Tso W.Y.W. and Wong W.H.S., Effectiveness of a Culturally Attuned Internet-based Depression Prevention Program for Chinese Adolescents: A Randomized Controlled Trial, Depression and Anxiety. 2016. |
| Lee S.L., Lau Y.L., Wong W.H.S. and Tian L., Prevalence of and Risk Factors for Childhood Asthma, Rhinitis, and Eczema in Hong Kong: Proposal for a Cross-Sectional Survey, JMIR Research Protocols. 2017, 6: e106. |
| Lo C.K.M., Tung T.S., Chan L.K., Yip P.S.F., Lau J.T.F., Wong W.H.S., Wong R.S.M., Tsang A.M.C., Tsang H.Y.H., Tso W.Y.W. and Ip P., Risk factors for child physical abuse and neglect among Chinese young mothers, Child Abuse & Neglect. 2017, 67: 193-206. |
| YEUNG K.S., Chung B.H.Y., Choufani S., Mok M.Y.T., Wong W.L., MAK C.C.Y., Yang W., Lee P.P.W., Wong W.H.S., Chen Y.A., Grafodatskaya D., Wong W.S.R., Lau W.C.S., Chan D.T.M., Weksberg R., Lau Y.L. and Crispin J.C., Genome-Wide DNA Methylation Analysis of Chinese Patients with Systemic Lupus Erythematosus Identified Hypomethylation in Genes Related to the Type I Interferon Pathway, PLOS ONE. 2017, 12: e0169553. |
| YEUNG K.S., Chung B.H.Y., Choufani S., Mok M.Y.T., Wong W.L., MAK C.C.Y., Yang W., Lee P.P.W., Wong W.H.S., Chen Y.A., Grafodatskaya D., Wong R.M.S., Lau W.C.S., Chan T.M., Weksberg R. and Lau Y.L., Genome-wide DNA methylation analysis of Chinese patients with systemic lupus erythematosus identified hypomethylation in genes to type I interferon pathway [PONE-D-16-30852R1], accepted, PLOS One. 2017. |
| Researcher : Wong WL |
| List of Research Outputs |
| LEUNG K.C., Ying D., MAK C.C.Y., Chen X.Y., Xu W., YEUNG K.S., Wong W.L., Chu W.Y., Mok T.K.G., Chau S.K.C., McLuskey J., Ong W.P.T., Leong H.Y., Chan Y.K., Yang W., Chen J.H., Li A.M., Sham P.C., Lau Y.L., Chung B.H.Y. and Lee S.L., CFTR founder mutation causes protein trafficking defects in Chinese patients with cystic fibrosis , Molecular Genetics & Genomic Medicine. 2016. |
| Luk H.M., YEUNG K.S., Wong W.L., Chung B.H.Y., Tong T.M.F. and Lo I.F.M., Silver-Russell syndrome in Hong Kong, Hong Kong Medical Journal. 2016, 22(6): 526-533. |
| YEUNG K.S., Chung B.H.Y., Choufani S., Mok M.Y.T., Wong W.L., MAK C.C.Y., Yang W., Lee P.P.W., Wong W.H.S., Chen Y.A., Grafodatskaya D., Wong W.S.R., Lau W.C.S., Chan D.T.M., Weksberg R., Lau Y.L. and Crispin J.C., Genome-Wide DNA Methylation Analysis of Chinese Patients with Systemic Lupus Erythematosus Identified Hypomethylation in Genes Related to the Type I Interferon Pathway, PLOS ONE. 2017, 12: e0169553. |
| YEUNG K.S., Chung B.H.Y., Choufani S., Mok M.Y.T., Wong W.L., MAK C.C.Y., Yang W., Lee P.P.W., Wong W.H.S., Chen Y.A., Grafodatskaya D., Wong R.M.S., Lau W.C.S., Chan T.M., Weksberg R. and Lau Y.L., Genome-wide DNA methylation analysis of Chinese patients with systemic lupus erythematosus identified hypomethylation in genes to type I interferon pathway [PONE-D-16-30852R1], accepted, PLOS One. 2017. |
| Researcher : Xiang Z |
| List of Research Outputs |
| CHEN Q., Liu Y., Lv A., NI K., Xiang Z., WEN K. and Tu W., Influenza virus infection exacerbates experimental autoimmune encephalomyelitis disease by promoting type I T cells infiltration into central nervous system, Journal of Autoimmunity. 2017, 77: 1-10. |
| Liu Y., Zheng J., Liu Y., WEN L., Huang L., Xiang Z., Lam K.T., Lv A., Mao H., Lau Y.L. and Tu W., Uncompromised NK cell activation is essential for virus-specific CTL activity during acute influenza virus infection, Cellular & Molecular Immunology. 2017. |
| Researcher : YEUNG KS |
| List of Research Outputs |
| Chung B.H.Y., YEUNG K.S., Tso W.Y.W., Ying D., Ip J.K.J., Chu W.Y., LEUNG K.C. and MAK C.C.Y., Exome sequencing of a Chinese patient cohort with ID/ASD and macrocephaly/megalencephaly: Identification of a patient with biallelic PTEN mutations and others with germline/ post-zygotic mutations in PIK3C-AKT-mTOR pathway, 17th Manchester Dysmorphology Conference, Manchester, UK, 7-10 November 2016. |
| LEUNG K.C., Ying D., MAK C.C.Y., Chen X.Y., Xu W., YEUNG K.S., Wong W.L., Chu W.Y., Mok T.K.G., Chau S.K.C., McLuskey J., Ong W.P.T., Leong H.Y., Chan Y.K., Yang W., Chen J.H., Li A.M., Sham P.C., Lau Y.L., Chung B.H.Y. and Lee S.L., CFTR founder mutation causes protein trafficking defects in Chinese patients with cystic fibrosis , Molecular Genetics & Genomic Medicine. 2016. |
| LEUNG K.C., Ying D., MAK C.C.Y., Chen X.Y., Xu W., YEUNG K.S., Chu W.Y., Mok T.K.G., Chau S.K.C., McLuskey J., Ong W.P.T., Leong H.Y., Chan Y.K., Yang W., Chen J.H., Li A.M., Lau Y.L., Lee S.L. and Chung B.H.Y., Identification of a CFTR founder mutations, c.3068T>G:p.I1023R, which causes protein trafficking defects in Chinese patients with cystic fibrosis, Asian Society for Pediatric Research (ASPR) and Faculty of Medicine Ramathibodi Hospital 2016, Thailand, Bangkok, 10-12 November 2016. |
| LEUNG K.C., Ying D., Shek N.W.M., Chu W.Y., YEUNG K.S., Tang M.H.Y., Kan S.Y.A., Chan Y.K., Ip J.K.J., Yang W., Lau Y.L. and Chung B.H.Y., Identification of a novel homozygous missense mutation in ABR causing cerebellar hypoplasia with early lethality, Asian Society for Pediatric Research (ASPR) and Faculty of Medicine Ramathibodi Hospital 2016, Thailand, Bangkok, 10-12 November 2016. |
| Luk H.M., YEUNG K.S., Wong W.L., Chung B.H.Y., Tong T.M.F. and Lo I.F.M., Silver-Russell syndrome in Hong Kong, Hong Kong Medical Journal. 2016, 22(6): 526-533. |
| MAK C.C.Y., Chow P.C., Liu A.P.Y., Chan Y.K., Chu W.Y., Mok T.K.G., LEUNG K.C., YEUNG K.S., Chau A.K.T., Lowther C., Scherer S.W., Marshall C.R., Bassett A.S. and Chung B.H.Y., De novo large rare copy-number variations contribute to conotruncal heart disease in Chinese patients, npj Genomic Medicine. 2016, 1: 16033. |
| Tso W.Y.W., YEUNG K.S., Ip J.K.J., Liu A.P.Y., Lee P.P.W., Chu W.Y., Chong C.Y., Ho M.H.K., Chan G.C.F., Lau Y.L. and Chung B.H.Y., The genetics of macrocephaly, autistic spectrum disorders and developmental delay in Chinese children. British Paediatric Neurology Association Annual Meeting, 11-13 January 2017, UK [Poster Presentations], Developmental Medicine & Child Neurology. 2017, 59: 19-108. |
| YEUNG K.S., Chung B.H.Y., Choufani S., Mok M.Y.T., Wong W.L., MAK C.C.Y., Yang W., Lee P.P.W., Wong W.H.S., Chen Y.A., Grafodatskaya D., Wong W.S.R., Lau W.C.S., Chan D.T.M., Weksberg R., Lau Y.L. and Crispin J.C., Genome-Wide DNA Methylation Analysis of Chinese Patients with Systemic Lupus Erythematosus Identified Hypomethylation in Genes Related to the Type I Interferon Pathway, PLOS ONE. 2017, 12: e0169553. |
| YEUNG K.S., Chung B.H.Y., Choufani S., Mok M.Y.T., Wong W.L., MAK C.C.Y., Yang W., Lee P.P.W., Wong W.H.S., Chen Y.A., Grafodatskaya D., Wong R.M.S., Lau W.C.S., Chan T.M., Weksberg R. and Lau Y.L., Genome-wide DNA methylation analysis of Chinese patients with systemic lupus erythematosus identified hypomethylation in genes to type I interferon pathway [PONE-D-16-30852R1], accepted, PLOS One. 2017. |
| YEUNG K.S., Ip J.K.J., Chow C.P., Kuong E.E.Y.L., Tam P.K.H., Chan G.C.F. and Chung B.H.Y., Somatic PIK3CA mutations in seven patients with PIK3CA-related overgrowth spectrum, American Journal of Medical Genetics Part A. 2017, 173A: 978-984. |
| Researcher : YEUNG PL |
| List of Research Outputs |
| Hui K.F., YEUNG P.L. and Chiang A.K.S., Targeting the survival function of ebna-3c protein in ebv-positive burkitt and lymphoblastoid cells by histone deacetylase and proteasome inhibitors, 17th Symposium on Epstein Barr Virus and Associated Disease, Zurich, Switzerland. 2016. |
| Researcher : Yang J |
| List of Research Outputs |
| Ben-Ali M., Yang J., Chan K.W., Ben-Mustapha I., Yang W., Lau Y.L. and Barbouche M.R., Homozygous transcription factor 3 gene (TCF3) mutation is associated with severe hypogammaglobulinemia and B-cell acute lymphoblastic leukemia., J Allergy Clin Immunol.. 2017, S0091-6749(17)30794-7. |
| WANG Y., GUO M., WANG T., Zhang Y., Yang J., Lau Y.L. and Yang W., Functional Properties of Genomic Region Associated with Multiple Traits in Genome-Wide Association Studies, The American Society of Human Genetics 2016. |
| Researcher : Yang LH |
| List of Research Outputs |
| Lau A.S.Y., Yang L.H., Chik S.C.C., Law H.Y. and Lee D.C.W., Coriolus Versicolor Extracts, Methods of Preparation and Uses Thereof. Japanese patent No. 5959523., 2016. |
| Law H.Y., Yang L.H., Lau A.S.Y. and Chan G.C.F., Mechanism of action and molecular identification of individual bio-active constituents from an effective traditional Chinese medicine decoction in treating influenza virus infection. Submitted to Journal of Antimicrobial Chemotherapy, 2016. |
| Researcher : Yang M |
| Project Title: | Protective effect of thrombopoietin on iron-induced cardiomyopathy |
| Investigator(s): | Yang M |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Children's Thalassaemia Foundation - General Awards |
| Start Date: | 07/2007 |
| Project Title: | The effect of melatonin in the treatment of thrombocytopenia |
| Investigator(s): | Yang M |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Queen Mary Hospital Charitable Trust - Training and Research Assistance Scheme |
| Start Date: | 01/2008 |
| Project Title: | The protective effects of thrombopoietin and amlodipine on iron overload-induced human mesenchymal stem cell damage: its impact on iron overload related osteopenia & osteoporosis |
| Investigator(s): | Yang M, Chan GCF, Cheung YF, Liu C |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Children's Thalassaemia Foundation - General Awards |
| Start Date: | 01/2009 |
| Researcher : Yang W |
| Project Title: | Identifying susceptibility genes in the human MHC region independently associated with systemic lupus erythematosus (SLE) in Chinese populations |
| Investigator(s): | Yang W, Lau YL, Sham PC |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Completion Date: | 12/2016 |
| Project Title: | Molecular diagnosis for severe combined immunodeficiencies (SCID) using whole exome sequencing |
| Investigator(s): | Yang W, Lau YL, Lee PPW, Chung BHY, Yang J |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 02/2014 |
| Completion Date: | 03/2017 |
| Project Title: | Meta-Analysis of three GWAS datasets from Hong Kong, Anhui China and UK followed by replication in independent cohorts in Asia and UK for identification of novel susceptibility genes associated with SLE |
| Investigator(s): | Yang W, Sham PC, Lau YL, Yang J |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2014 |
| Project Title: | Meta-analysis of SLE GWAS followed by replication on X chromosome in cross-ethnic populations |
| Investigator(s): | Yang W, Lau YL, Yang J |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2015 |
| Project Title: | Haplotype-based analysis of genome-wide association study data to uncover genes associated with SLE in Hong Kong and other Asian populations |
| Investigator(s): | Yang W |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2015 |
| Completion Date: | 11/2016 |
| Project Title: | Understanding gene expression changes in Systemic Lupus Erythematosus through a systems approach |
| Investigator(s): | Yang W |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2016 |
| Project Title: | Unravelling the genetic puzzle of systemic lupus erythematosus (SLE) through comprehensive analyses of genetic association by functional annotation of genes, variants, and genomic regions |
| Investigator(s): | Yang W, Lau YL, Chung BHY, Sham PC |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2016 |
| Project Title: | annual meeting of american society of human genetics; Genetic factors for lupus nephritis in Asian populations |
| Investigator(s): | Yang W |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 10/2016 |
| Completion Date: | 10/2016 |
| Project Title: | Sub-phenotype analysis of systemic lupus erythematosus for novel loci with disease association and lupus nephritis predisposition |
| Investigator(s): | Yang W |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2017 |
| Project Title: | Development of a genetic testing method by next generation sequencing for Thalassaemia - a pilot study |
| Investigator(s): | Yang W, Ha SY, So JCC, Ip HW, Yang J |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Children's Thalassaemia Foundation - General Awards |
| Start Date: | 06/2017 |
| List of Research Outputs |
| Ben-Ali M., Yang J., Chan K.W., Ben-Mustapha I., Yang W., Lau Y.L. and Barbouche M.R., Homozygous transcription factor 3 gene (TCF3) mutation is associated with severe hypogammaglobulinemia and B-cell acute lymphoblastic leukemia., J Allergy Clin Immunol.. 2017, S0091-6749(17)30794-7. |
| CHEN R., Lau Y.L., Zhang Y. and Yang W., SRinversion: a tool for detecting short inversions by splitting and re-aligning poorly mapped and unmapped sequencing reads, Bioinformatics. Oxford University Press, 2016, 32: 3559-3565. |
| Jiang S S., Tang L., Zhao N., Yang W., Qiu Y. and Chen H.Z., A Systems View of the Differences between APOE ε4 Carriers and Non-carriers in Alzheimer's Disease, Front Aging Neurosci.. 2016, 8: 171. |
| Kwok J.S.Y., GUO M., Yang W., Lee C.K., Chan N.K., Ho J., Tang W.H., Chan Y.S., Middleton D., Lu L. and Chan G.C.F., HLA-A, -B and -DRB1 genotyping and haplotype frequencies of 3892 cord blood units in the Hong Kong Chinese Cord Blood Registry, Human Immunology. 2016, 77: 1109-1110. |
| Kwok J.S.Y., GUO M., Yang W., Lee C.K., Ho J., Tang W.H., Chan Y.S., Middleton D., Lu L. and Chan G.C.F., HLA-A, -B, -C, and -DRB1 genotyping and haplotype frequencies for a Hong Kong Chinese population of 7595 individuals, Human Immunology. ELSEVIER, 2016, 77: 1111-1112. |
| LEUNG K.C., Ying D., MAK C.C.Y., Chen X.Y., Xu W., YEUNG K.S., Wong W.L., Chu W.Y., Mok T.K.G., Chau S.K.C., McLuskey J., Ong W.P.T., Leong H.Y., Chan Y.K., Yang W., Chen J.H., Li A.M., Sham P.C., Lau Y.L., Chung B.H.Y. and Lee S.L., CFTR founder mutation causes protein trafficking defects in Chinese patients with cystic fibrosis , Molecular Genetics & Genomic Medicine. 2016. |
| LEUNG K.C., Ying D., MAK C.C.Y., Chen X.Y., Xu W., YEUNG K.S., Chu W.Y., Mok T.K.G., Chau S.K.C., McLuskey J., Ong W.P.T., Leong H.Y., Chan Y.K., Yang W., Chen J.H., Li A.M., Lau Y.L., Lee S.L. and Chung B.H.Y., Identification of a CFTR founder mutations, c.3068T>G:p.I1023R, which causes protein trafficking defects in Chinese patients with cystic fibrosis, Asian Society for Pediatric Research (ASPR) and Faculty of Medicine Ramathibodi Hospital 2016, Thailand, Bangkok, 10-12 November 2016. |
| LEUNG K.C., Ying D., Shek N.W.M., Chu W.Y., YEUNG K.S., Tang M.H.Y., Kan S.Y.A., Chan Y.K., Ip J.K.J., Yang W., Lau Y.L. and Chung B.H.Y., Identification of a novel homozygous missense mutation in ABR causing cerebellar hypoplasia with early lethality, Asian Society for Pediatric Research (ASPR) and Faculty of Medicine Ramathibodi Hospital 2016, Thailand, Bangkok, 10-12 November 2016. |
| Lung M.L., Dai W., ZHENG H., Ko J.M.Y., Sham P.C., Yang W., Cherny S.S., Ngan R.K.C., Kwong D.L.W., Ng W.T., Chiang A.K.S. and Lee W.M.A., Elucidating the Genetic Basis for Early-age Onset Nasopharyngeal Carcinoma in Hong Kong, Health Research Symposium 2017, Hong Kong. June 16, 2017.. 2017. |
| Molineros J.E., Yang W., Zhou X.J., Sun C., Okada Y., ZHANG H., Heng Chua K., Lau Y.L., Kochi Y., Suzuki A., Yamamoto K., Ma J., Bang S.Y., Lee H.S., Kim K K., Bae S.C., Zhang H., Shen N., Looger L.L. and Nath SK S.K., Confirmation of five novel susceptibility loci for systemic lupus erythematosus (SLE) and integrated network analysis of 82 SLE susceptibility loci., Human Molecular Genetics. Oxford University Press, 2017, 26: 1205-1216. |
| Morris D.L., Sheng Y., Zhang Y., WANG Y., Zhu Z., Tombleson P., Chen L., Cunninghame Graham D.S., Bentham J., Roberts A.L., CHEN R., Zuo X., WANG T., Wen L., Yang C., Liu L., Yang L., Li F., Huang Y., Yin X., Yang S., Rönnblom L., Fürnrohr B.G., Voll R.E., Schett G., Costedoat-Chalumeau N., Gaffney P.M., Lau Y.L., Zhang X X., Yang W., Cui Y. and Vyse T.J., Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus., Nature Genetics. 2016, 48: 940–946. |
| WANG Y., GUO M., WANG T., Zhang Y., Yang J., Lau Y.L. and Yang W., Functional Properties of Genomic Region Associated with Multiple Traits in Genome-Wide Association Studies, The American Society of Human Genetics 2016. |
| YEUNG K.S., Chung B.H.Y., Choufani S., Mok M.Y.T., Wong W.L., MAK C.C.Y., Yang W., Lee P.P.W., Wong W.H.S., Chen Y.A., Grafodatskaya D., Wong W.S.R., Lau W.C.S., Chan D.T.M., Weksberg R., Lau Y.L. and Crispin J.C., Genome-Wide DNA Methylation Analysis of Chinese Patients with Systemic Lupus Erythematosus Identified Hypomethylation in Genes Related to the Type I Interferon Pathway, PLOS ONE. 2017, 12: e0169553. |
| YEUNG K.S., Chung B.H.Y., Choufani S., Mok M.Y.T., Wong W.L., MAK C.C.Y., Yang W., Lee P.P.W., Wong W.H.S., Chen Y.A., Grafodatskaya D., Wong R.M.S., Lau W.C.S., Chan T.M., Weksberg R. and Lau Y.L., Genome-wide DNA methylation analysis of Chinese patients with systemic lupus erythematosus identified hypomethylation in genes to type I interferon pathway [PONE-D-16-30852R1], accepted, PLOS One. 2017. |
| Zhang F., Wu L., Qian J., Qu B., Xia S., La T., Wu Y., Ma J., Zeng J., Guo Q., Cui Y., Yang W., Huang J., Zhu W., Yao Y., Shen N. and Tang Y., Journal of Autoimmunity, Identification of the long noncoding RNA NEAT1 as a novel inflammatory regulator acting through MAPK pathway in human lupus. Elsevier, 2016, 75: 96-104. |
| Zhou X.J., Nath S.K., Qi Y.Y., Sun C., Hou P., Zhang Y.M., Lv J.C., Shi S.F., Liu L.J., CHEN R., Yang W., He K.Z., Li Y. and Zhang H., Novel identified associations of RGS1 and RASGRP1 variants in IgA Nephropathy., Scientific Reports. 2016. |
| Researcher : Yick LW |
| Project Title: | Defining the roles of epidermal growth factor (EGF) in the regulation of chondrocyte differentiation and endochondral bone formation |
| Investigator(s): | Yick LW, Chan SY |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2004 |
| Researcher : Ying D |
| List of Research Outputs |
| Chung B.H.Y., YEUNG K.S., Tso W.Y.W., Ying D., Ip J.K.J., Chu W.Y., LEUNG K.C. and MAK C.C.Y., Exome sequencing of a Chinese patient cohort with ID/ASD and macrocephaly/megalencephaly: Identification of a patient with biallelic PTEN mutations and others with germline/ post-zygotic mutations in PIK3C-AKT-mTOR pathway, 17th Manchester Dysmorphology Conference, Manchester, UK, 7-10 November 2016. |
| LEUNG K.C., Ying D., MAK C.C.Y., Chen X.Y., Xu W., YEUNG K.S., Wong W.L., Chu W.Y., Mok T.K.G., Chau S.K.C., McLuskey J., Ong W.P.T., Leong H.Y., Chan Y.K., Yang W., Chen J.H., Li A.M., Sham P.C., Lau Y.L., Chung B.H.Y. and Lee S.L., CFTR founder mutation causes protein trafficking defects in Chinese patients with cystic fibrosis , Molecular Genetics & Genomic Medicine. 2016. |
| LEUNG K.C., Ying D., MAK C.C.Y., Chen X.Y., Xu W., YEUNG K.S., Chu W.Y., Mok T.K.G., Chau S.K.C., McLuskey J., Ong W.P.T., Leong H.Y., Chan Y.K., Yang W., Chen J.H., Li A.M., Lau Y.L., Lee S.L. and Chung B.H.Y., Identification of a CFTR founder mutations, c.3068T>G:p.I1023R, which causes protein trafficking defects in Chinese patients with cystic fibrosis, Asian Society for Pediatric Research (ASPR) and Faculty of Medicine Ramathibodi Hospital 2016, Thailand, Bangkok, 10-12 November 2016. |
| LEUNG K.C., Ying D., Shek N.W.M., Chu W.Y., YEUNG K.S., Tang M.H.Y., Kan S.Y.A., Chan Y.K., Ip J.K.J., Yang W., Lau Y.L. and Chung B.H.Y., Identification of a novel homozygous missense mutation in ABR causing cerebellar hypoplasia with early lethality, Asian Society for Pediatric Research (ASPR) and Faculty of Medicine Ramathibodi Hospital 2016, Thailand, Bangkok, 10-12 November 2016. |
| Researcher : Yung AWY |
| List of Research Outputs |
| Chau S.K.C., Yung A.W.Y. and Lee S.L., Long-Term Management for Ventilator-Assisted Children in Hong Kong: 2 Decades' Experience, Respiratory Care. 2017, 62: 54-64. |
| Fu K.W., Ho F.K.W., Rao N., Fan F.J., Li L., Lee T.M.C., Chan H.S.S., Yung A.W.Y., Young Y.M.E. and Ip P., Parental restriction reduces the harmful effects of in-bedroom electronic devices, Archives of Disease in Childhood. 2017, archdischild-2017-312639. |
| TSANG H.Y., LEUNG K.C., MAK C.C.Y., Miu X., Lee S.L., Chan G.C.F., Yung A.W.Y. and Chung B.H.Y., Genetic diagnosis of drug-resistant epilepsy by whole exome sequencing and chromosomal array in Hong Kong, Hong Kong College of Paediatricians, 4th Annual Scientific Meeting cum 5th Hong Kong-Guangdong-Shanghai-Chongqing Paediatric Exchange Meeting, HK, 3-4 December 2016. |
| TSANG H.Y., LEUNG K.C., MAK C.C.Y., Chu W.Y., Mu X., Lee S.L., Chan G.C.F., Yung A.W.Y. and Chung B.H.Y., Genetic diagnosis of early onset epilepsy by whole exome sequencing and chromosomal array in Hong Kong, Asian Society for Pediatric Research (ASPR) and Faculty of Medicine Ramathibodi Hospital 2016, Thailand, Bangkok, 10-12 November 2016. |
| Researcher : ZHANG H |
| List of Research Outputs |
| Molineros J.E., Yang W., Zhou X.J., Sun C., Okada Y., ZHANG H., Heng Chua K., Lau Y.L., Kochi Y., Suzuki A., Yamamoto K., Ma J., Bang S.Y., Lee H.S., Kim K K., Bae S.C., Zhang H., Shen N., Looger L.L. and Nath SK S.K., Confirmation of five novel susceptibility loci for systemic lupus erythematosus (SLE) and integrated network analysis of 82 SLE susceptibility loci., Human Molecular Genetics. Oxford University Press, 2017, 26: 1205-1216. |
| Researcher : Zhang Y |
| Project Title: | The ASHG 64th Annual Meeting; Meta-analysis on the 22q11.21 region identifies an autoimmune disease risk allele as associated with systemic lupus erythematosus |
| Investigator(s): | Zhang Y |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 10/2014 |
| List of Research Outputs |
| CHEN R., Lau Y.L., Zhang Y. and Yang W., SRinversion: a tool for detecting short inversions by splitting and re-aligning poorly mapped and unmapped sequencing reads, Bioinformatics. Oxford University Press, 2016, 32: 3559-3565. |
| Morris D.L., Sheng Y., Zhang Y., WANG Y., Zhu Z., Tombleson P., Chen L., Cunninghame Graham D.S., Bentham J., Roberts A.L., CHEN R., Zuo X., WANG T., Wen L., Yang C., Liu L., Yang L., Li F., Huang Y., Yin X., Yang S., Rönnblom L., Fürnrohr B.G., Voll R.E., Schett G., Costedoat-Chalumeau N., Gaffney P.M., Lau Y.L., Zhang X X., Yang W., Cui Y. and Vyse T.J., Genome-wide association meta-analysis in Chinese and European individuals identifies ten new loci associated with systemic lupus erythematosus., Nature Genetics. 2016, 48: 940–946. |
| WANG Y., GUO M., WANG T., Zhang Y., Yang J., Lau Y.L. and Yang W., Functional Properties of Genomic Region Associated with Multiple Traits in Genome-Wide Association Studies, The American Society of Human Genetics 2016. |
| Researcher : Zheng J |
| Project Title: | Gammadelta-T cell-targeted therapy on the formation of adaptive immunity against influenza virus infection |
| Investigator(s): | Zheng J, Tu W, Liu Y, Lau YL |
| Department: | Paediatrics & Adolescent Med |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 01/2016 |
| List of Research Outputs |
| Liu Y., Zheng J., Liu Y., WEN L., Huang L., Xiang Z., Lam K.T., Lv A., Mao H., Lau Y.L. and Tu W., Uncompromised NK cell activation is essential for virus-specific CTL activity during acute influenza virus infection, Cellular & Molecular Immunology. 2017. |
| Tu W. and Zheng J., Application of Humanized Mice in Immunological Research, In: Maria Cristina Cuturi and Ignacio Anegon , Suppression and Regulation of Immune Responses: Methods and Protocols, Volume II, Methods in Molecular Biology. New York, Springer Science+Business Media, 2016, 1371: 157-176. |