DEPT OF ANAESTHESIOLOGY



Researcher : Cai Y

Project Title:Rap1 exacerbates myocardial ischemia/reperfusion injury through enhancing cell apoptosis and inflammatory response
Investigator(s):Cai Y, Xia Z, Irwin MG
Department:Anaesthesiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:08/2017


List of Research Outputs

Cai Y., Young Scientist Travel Award (WCP2018), American Society of Pharmacology & Experimental Therapeutics . 2018.
HE Y., Cai Y., Liu H., Irwin M.G. and Xia Z., Overexpression of miR-503-5p exacerbates hypoxia/reoxygenation injury in H9C2 cardiomyocytes, 2019, 33 (Supp 1): 674.
Leung S.W.S., Cai Y., ZHANG Y., Vanhoutte P.M.G.R., Sun X., Feinberg M.W. and Man R.Y.K., Upregulation of miRNA-17-3p reduces inflammatory responses in rats, The 8th Scientific Meeting of Asian Society for Vascular Biology (ASVB), 2 to 4 November 2018, Shanghai, China. 2018.
REN W., Cai Y., Zhang Y., Ho Y.W., Lam J.K.W., Vanhoutte P.M.G.R. and Leung S.W.S., MicroRNA-17-3p blunts endothelial responses to inflammatory stimuli, 13th MOVD / 7th EDH 2019, Rotterdam, The Netherlands, May 20-22, 2019.


Researcher : Chan TCW

List of Research Outputs

Wong S.C.S., Chan T.C.W., Chung Y.F., Fang C.X. and Cheung C.W., Effects of Infraclavicular nerve block versus General Anaesthesia for Acute postoperative pain after distal radial fracture surgery, 17th World Congress on Pain (2018), Boston, USA. 2018.


Researcher : Cheung CW

Project Title:Cash donation to support service and clinical research (Pain Management)
Investigator(s):Cheung CW, Irwin MG
Department:Anaesthesiology
Source(s) of Funding:Cash donation for supporting service and clinical research
Start Date:11/2013


Project Title:Determining the role of histone deacetylase 2 (HDAC2) in the pathogenesis of chemotherapy-induced peripheral neuropathy (CIPN)
Investigator(s):Cheung CW
Department:Anaesthesiology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:05/2018


Project Title:Determination of the role of nucleocytoplasmic shuttling of histone deacetylase 5 (HDAC5) in the central anti-nociceptive effect mediated by endothelin-1 (ET-1) on neuropathic pain
Investigator(s):Cheung CW, Wong SCS, Chan YS
Department:Anaesthesiology
Source(s) of Funding:Seed Fund for Basic Research for Resubmission of GRF/ECS Proposals
Start Date:07/2018
Completion Date:11/2018


List of Research Outputs

Cheung C.W. and Irwin M.G., Pain Management, Anesthesia & Analgesia. 2018, 1.
Choi W.W.S. and Cheung C.W., Is Ketamine Effective in Reducing Postoperative Discomfort in Third Molar Surgery? a Randomised Controlled Trial, 100th Annual Meeting of the American Association of Oral and Maxillofacial Surgeons. 2018.
Choi W.W.S. and Cheung C.W., Oral Abstract Scientific Presentation Award, American Association of Oral and Maxillofacial Surgeons. 2018.
Chow W.C., Cheng K.S., Leong F., Cheung C.W., Shiao L.R., Leung Y.M. and Wong K., Enhancing Tetrandrine Cytotoxicity In Human Lung Carcinoma A549 Cells By Suppressing Mitochondrial Atp Production, Naunyn-schmiedeberg's Archives Of Pharmacology. 2019, 392: 427-436.
Leorey N S., Nada L., Zhang J.Z., Cheung C.W. and Wang X.M.A., Altered Cd8+ T Lymphocyte Response Triggered By Arginase 1: Implication For Fatigue Intensification During Localized Radiation Therapy In Prostate Cancer Patients, Neuropsychiatry. 2018, 08.
Pan Z.Q., Shan Q., GU P., Wang X.M.A., Tai W., Sun M.L., Luo X., Sun L.T. and Cheung C.W., miRNA-23a/CXCR4 regulates neuropathic pain via directly targeting TXNIP/NLRP3 inflammasome axis, Journal of Neuroinflammation. 2018, 15.
TAI W.L., Yeung S.C. and Cheung C.W., Enriched Environment And Effects On Neuropathic Pain: Experimental Findings And Mechanisms, Pain Practice. 2018, 18: 1068-1082.
TAI W.L., Pan Z., Sun L.T., Li H., GU P., Wong S.C.S., Chung S.K. and Cheung C.W., Suppression of Pax2 Attenuates Allodynia and Hyperalgesia through ET-1–ETAR–NFAT5 Signaling in a Rat Model of Neuropathic Pain, Neuroscience. 2018, 384: 139-151.
Wong S.C.S., Chan T.C.W., Chung Y.F., Fang C.X. and Cheung C.W., Effects of Infraclavicular nerve block versus General Anaesthesia for Acute postoperative pain after distal radial fracture surgery, 17th World Congress on Pain (2018), Boston, USA. 2018.
Wong S.C.S., Choi S.W. and Cheung C.W., Intraoperative Total Intravenous Anaesthesia is associated with reduced postoperative opioid consumption after colorectal surgery., 17th World Congress on Pain (2018), Boston, USA. 2018.
Wong S.C.S., Sun L.T., QIU Q., GU P., Li Q., Wang X.M.A. and Cheung C.W., Propofol attenuates postoperative hyperalgesia via regulating spinal GluN2B-p38MAPK/EPAC1 pathway in an animal model of postoperative pain, European Journal of Pain. 2018.
Wong S.C.S., Choi S.W., Lee Y., Irwin M.G. and Cheung C.W., The analgesic effects of intraoperative total intravenous anesthesia (TIVA) with propofol versus sevoflurane after colorectal surgery, Medicine. 2018, 97: e11615.
Wong S.C.S., Leung M.Y.Y. and Cheung C.W., The effect of total intravenous anaesthesia with propofol on postoperative pain after third molar surgery: a double blind randomized controlled trial, European Journal of Pain. 2018.
XIE X., YAN D., Li H., Zhu Q., Li J., Fang Y.P., Cheung C.W., Irwin M.G., Xia Z. and Lian Q., Enhancement of Adiponectin Ameliorates Nonalcoholic Fatty Liver Disease via Inhibition of FoxO1 in Type I Diabetic Rats, Journal of Diabetes Research. 2018, 2018: 1-9.
Zhu D., Fan T.T., Huo W.Y., Cui J., Cheung C.W. and Xia Z.Y., Progressive Increase Of Inflammatory Cxcr4 And Tnf-alpha In The Dorsal Root Ganglia And Spinal Cord Maintains Peripheral And Central Sensitization To Diabetic Neuropathic Pain In Rats, Mediators Of Inflammation. 2019, 2019: 1-11.


Researcher : Choi SW

List of Research Outputs

Cheung V., Yuen V.M.Y., Wong G.T.C. and Choi S.W., The effect of sleep deprivation and disruption on DNA damage and health of doctors, Anaesthesia. 2019, 74: 434-440.
Wong S.C.S., Choi S.W. and Cheung C.W., Intraoperative Total Intravenous Anaesthesia is associated with reduced postoperative opioid consumption after colorectal surgery., 17th World Congress on Pain (2018), Boston, USA. 2018.
Wong S.C.S., Choi S.W., Lee Y., Irwin M.G. and Cheung C.W., The analgesic effects of intraoperative total intravenous anesthesia (TIVA) with propofol versus sevoflurane after colorectal surgery, Medicine. 2018, 97: e11615.


Researcher : Chu MT

List of Research Outputs

Chang R.C.C., LIU Y., Chu M.T., Jin J. and Wong G.T.C., Short-term resistant exercise ameliorates cognitive dysfunction in 9-month 3xTg Mice, The 14th International Symposium on Alzheimer’s & Parkinson’s Diseases. 2019, #405.
HUANG C., Chu M.T., LIU Y., Chang R.C.C. and Wong G.T.C., Varenicline reduces DNA damage, tau mislocalization and post surgical cognitive impairment in aged mice, Neuropharmacology. 2018, 143: 217-227.
Xiong W., Zhao G.D., Yin X., Linghu K.G., Chu M.T., Wong G.T.C., Li H., Yu H. and Wang Y.T., Brij-grafted-chitosan copolymers with function of P-glycoprotein modulation: Synthesis, characterization and in vitro investigations, Carbohydrate Polymers. 2019, 204: 89-96.


Researcher : Chung YF

List of Research Outputs

Wong S.C.S., Chan T.C.W., Chung Y.F., Fang C.X. and Cheung C.W., Effects of Infraclavicular nerve block versus General Anaesthesia for Acute postoperative pain after distal radial fracture surgery, 17th World Congress on Pain (2018), Boston, USA. 2018.


Researcher : GU P

List of Research Outputs

Pan Z.Q., Shan Q., GU P., Wang X.M.A., Tai W., Sun M.L., Luo X., Sun L.T. and Cheung C.W., miRNA-23a/CXCR4 regulates neuropathic pain via directly targeting TXNIP/NLRP3 inflammasome axis, Journal of Neuroinflammation. 2018, 15.
TAI W.L., Pan Z., Sun L.T., Li H., GU P., Wong S.C.S., Chung S.K. and Cheung C.W., Suppression of Pax2 Attenuates Allodynia and Hyperalgesia through ET-1–ETAR–NFAT5 Signaling in a Rat Model of Neuropathic Pain, Neuroscience. 2018, 384: 139-151.
Wong S.C.S., Sun L.T., QIU Q., GU P., Li Q., Wang X.M.A. and Cheung C.W., Propofol attenuates postoperative hyperalgesia via regulating spinal GluN2B-p38MAPK/EPAC1 pathway in an animal model of postoperative pain, European Journal of Pain. 2018.


Researcher : HE Y

List of Research Outputs

HE Y., Cai Y., Liu H., Irwin M.G. and Xia Z., Overexpression of miR-503-5p exacerbates hypoxia/reoxygenation injury in H9C2 cardiomyocytes, 2019, 33 (Supp 1): 674.


Researcher : HUANG C

List of Research Outputs

HUANG C., Ng T.W., Irwin M.G., Hu X., Zhu S., Chang R.C.C. and Wong G.T.C., Differential effects of propofol and dexmedetomidine on neuroinflammation induced by systemic endotoxin lipopolysaccharides in adult mice, Australian and New Zealand College of Anaesthetists and Faculty of Pain Medicine ASM 2019.
HUANG C., Chu M.T., LIU Y., Chang R.C.C. and Wong G.T.C., Varenicline reduces DNA damage, tau mislocalization and post surgical cognitive impairment in aged mice, Neuropharmacology. 2018, 143: 217-227.
YOU R., Ho Y.S., Hung H.L.C., LIU Y., HUANG C., Chan H.N., Ho S.L., Lui S.Y., Li H.W. and Chang R.C.C., Silica nanoparticles induce neurodegeneration-like changes in behaviour, neuropathology, and affect synapse through MAPK activation, Particle Fibre Toxicology. 2018, 15: 28.


Researcher : Hui TWC

List of Research Outputs

Mohtar S., Hui T.W.C. and Irwin M.G., Anaesthetic management of thoracoscopic resection of lung lesions in small children, Paediatric Anaesthesia. 2018, 28(11): 1035-1042.


Researcher : Ip KY

List of Research Outputs

Ip K.Y., Tsai N.W.P. and Irwin M.G., Peri-operative optimization of elderly patients: a narrative review., anaethesia. 2019, 74 (Suppl 1): 80-89.
Ip K.Y., Tsai N.W.P. and Irwin M.G., Pre-operative cardiac optimization: a directed review, Anaesthesia. 2019, 74 (Suppl 1): 67-69.


Researcher : Irwin MG

Project Title:A comparative study of hydroxyethyl starch (130/0.4) and gelatin on the immune response in paediatric scoliosis surgery
Investigator(s):Irwin MG, Wylie SJ
Department:Anaesthesiology
Source(s) of Funding:Small Project Funding
Start Date:01/2009


Project Title:Radiofrequency therapy for chronic and cancer pain patient
Investigator(s):Irwin MG, Cheung CW
Department:Anaesthesiology
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:08/2010


Project Title:Repressor activator protein 1 increases the susceptibility to myocardial ischemia/reperfusion injury in type 2 diabetic mice
Investigator(s):Irwin MG, Vanhoutte PMGR, Wong GTC, Xia Z
Department:Anaesthesiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2018


List of Research Outputs

Ackland G.L., Brudney C.S., Cecconi M., Ince C., Irwin M.G., Lacey J., Pinsky M.R., Grocott M.P.W., Mythen M.G., Edwards M.R., Miller T.E., Mythen M.G., Grocott M.P.W., Edwards M.R., Ackland G.L., Brudney C.S., Cecconi M., Ince C.A.N., Sanders R., Hughes F., Bader A., Thompson A., Hoeft A., Williams D., Shaw A.D., Sessier D.I., Aronson S., Berry C., Gan T.J., Kellum J., Plumb J., Blookstone J., McEvoy M.D., Thacker J.K.M., Gapta R., Koepke E., Feldheiser A., Levett D., Michard F. and Hamilton M., Perioperative Quality Initiative consensus statement on the physiology of arterial blood pressure control in perioperative medicine, British Journal of Anaesthesia. 2019, 122: 542-551.
Cheung C.W. and Irwin M.G., Pain Management, Anesthesia & Analgesia. 2018, 1.
HE Y., Cai Y., Liu H., Irwin M.G. and Xia Z., Overexpression of miR-503-5p exacerbates hypoxia/reoxygenation injury in H9C2 cardiomyocytes, 2019, 33 (Supp 1): 674.
HUANG C., Ng T.W., Irwin M.G., Hu X., Zhu S., Chang R.C.C. and Wong G.T.C., Differential effects of propofol and dexmedetomidine on neuroinflammation induced by systemic endotoxin lipopolysaccharides in adult mice, Australian and New Zealand College of Anaesthetists and Faculty of Pain Medicine ASM 2019.
Ip K.Y., Tsai N.W.P. and Irwin M.G., Peri-operative optimization of elderly patients: a narrative review., anaethesia. 2019, 74 (Suppl 1): 80-89.
Ip K.Y., Tsai N.W.P. and Irwin M.G., Pre-operative cardiac optimization: a directed review, Anaesthesia. 2019, 74 (Suppl 1): 67-69.
Irwin M.G., Acta Anaesthesia Taiwanica, Editorial Board Member. 2019.
Irwin M.G., Anaesthesia and Intensive Care Medicine, Editorial Board member. 2019.
Irwin M.G., Anaesthesia, Editorial Board member. 2019.
Irwin M.G., Annual Meeting, 15th Asian Australasian Congress of Anaesthesiologists. 2018.
Irwin M.G., Annual Meeting, Association of Anaesthetists, Adelaide, Australia. 2018.
Irwin M.G., Annual Meeting, Koreanesthesia. 2018.
Irwin M.G., BioMed Central Perioperative Medicine, Editorial Board member (Associate Editor). 2019.
Irwin M.G., Expert Opinion on Pharmacotherapy, Editorial Board Member. 2019.
Irwin M.G., Grant Reviewer, ANZCA Clinical Trials Network (CTN), Australia. 2019.
Irwin M.G., Grant Reviewer, Australian Academy of Health and Medical Sciences. 2019.
Irwin M.G., Grant Reviewer, Croatian Science Foundation (HRZZ), Croatia. 2019.
Irwin M.G., Grant Reviewer, Hong Kong Research Grants Council, HK. 2019.
Irwin M.G., Grant Reviewer, National Institute of Academic Anaesthesia (NIAA), UK. 2019.
Irwin M.G., Grant Reviewer, National Natural Science Foundation of China (NSFC), China. 2019.
Irwin M.G., Grant Reviewer, SK Yee Medical Foundation, HK. 2019.
Irwin M.G., Grant Reviewer, The Netherlands Organization for Health Research and Development (ZonMw). 2019.
Irwin M.G., Grant reviewer, Health Services Research Committee/Health Care & Promotion Fund, HK. 2019.
Irwin M.G., Hong Kong Medical Journal, Editorial Board Member (Senior Editor Managing Reviews). 2019.
Irwin M.G., Journal of International Medical Research, Editorial Board Member. 2019.
Irwin M.G., Pain Research and Treatment, Editorial Board Member. 2019.
Irwin M.G., Peer Reviewer, Anaesthesia. 2019.
Irwin M.G., Peer Reviewer, Anaesthesia and Intensive Care. 2019.
Irwin M.G., Peer Reviewer, Anesthesia and Analgesia. 2019.
Irwin M.G., Peer Reviewer, Anesthesiology. 2019.
Irwin M.G., Peer Reviewer, British Journal of Anaesthesia. 2019.
Irwin M.G., Peer Reviewer, British Journal of Pharmacology. 2019.
Irwin M.G., Peer Reviewer, Canadian Journal of Anaesthesia. 2019.
Irwin M.G., Peer Reviewer, Canadian Journal of Physiology and Pharmacology. 2019.
Irwin M.G., Peer Reviewer, Diabetes. 2019.
Irwin M.G., Peer Reviewer, European Journal of Pharmacology. 2019.
Irwin M.G., Peer Reviewer, Expert Opinion on Investigational Drugs. 2019.
Irwin M.G., Peer Reviewer, International Immunopharmacology. 2019.
Irwin M.G., Peer Reviewer, Journal of Cardiothoracic and Vascular Anesthesia. 2019.
Irwin M.G., Peer Reviewer, Journal of Clinical Anaesthesia. 2019.
Irwin M.G., Peer Reviewer, Journal of Maxillofacial Surgery. 2019.
Irwin M.G., Peer Reviewer, Journal of Molecular and Cellular Cardiology. 2019.
Irwin M.G., Peer Reviewer, Journal of Neuroscience Methods. 2019.
Irwin M.G., Peer Reviewer, Journal of Paediatrics, Obstetrics and Gynaecology. 2019.
Irwin M.G., Peer Reviewer, Journal of Paediatrics, Obstetrics and Gynaecology. 2019.
Irwin M.G., Peer Reviewer, Journal of Pharmaceutical & Biomedical Analysis. 2019.
Irwin M.G., Peer Reviewer, Lancet. 2019.
Irwin M.G., Peer Reviewer, Medical Science Monitor. 2019.
Irwin M.G., Peer Reviewer, Oncotarget. 2019.
Irwin M.G., Peer Reviewer, Surgical Practice. 2019.
Irwin M.G. and Wong G.T.C., Taking on TIVA. Why we need guidelines on total intravenous anaesthesia, Anaesthesia. 2019, 74: 140-142.
Li A., Yuen V.M.Y., Goulay-Dufay S., Sheng Y., Standing J.F., Kwok P.C.L., Leung K.M.M., Leung A.S., Wong I.C.K. and Irwin M.G., Corrigendum to “Pharmacokinetic and pharmacodynamic study of intranasal and intravenous dexmedetomidine” (Br J Anaesth 2018; 120: 960–968), British Journal of Anaesthesia. 2018, 121 (3): 687.
McEvoy M.D., Gupta R., Koepke E.J., Feldheiser A., Michard F., Levettq D., Thacker J.K.M., Hamiltom M., Grocott M.P.W., Mythen M.G., Miller T.E., Edwards M.R., Miller T.E., Mythen M.G., Grocott M.P.W., Edwards M.R., Ackland G.L., Brudney C.S., Cecconi M., Ince C., Irwin M.G., Lacey J., Pinsky M.R., Sanders R., Hughes F., Bader A., Thompson A., Hoeft A., Williams D., Shaw A.D., Sessleer D.I., Aronson S., Berry C., Gan T.J., Kellum J., Plumb J., Bloomstone J., McEvoy M.D., Thacker J.K.M., Gupta R., Koepke E., Feldheiser A., Levett D., Michard F. and Hamilton M., Perioperative Quality Initiative consensus statement on postoperative blood pressure, risk and outcomes for elective surgery, British Journal of Anaesthesia. 2019, 122: 575-586.
Mohtar S., Hui T.W.C. and Irwin M.G., Anaesthetic management of thoracoscopic resection of lung lesions in small children, Paediatric Anaesthesia. 2018, 28(11): 1035-1042.
Sanders R.D., Hughes F., Shaw A., Thompson A., Bader A., Hoeft A., Williams D.A., Grocott M.P.W., Mythen M.G., Miller T.E., Edwards M.R., Ackland G.L., Brudney C.S., Cecconi M., Ince C., Irwin M.G., Lacey J., Pinsky M.R., Sanders R., Hughes F., Bader A., Thompson A., Hoeft A., William D., Shaw A.D., Sessier D.I., Aronson S., Berry C., Gan T.J., Kellum J., Plumb J., Bloomstone J., McEvoy M.D., thacker J.K.M., Gupta R., Koepke E.L.E.N.A., Feldheiser A., Levett D., Michard F. and Hamilton M., Perioperative Quality Initiative consensus statement on preoperative blood pressure, risk and outcomes for elective surgery, British Journal of Anaesthesia. 2019, 122: 552-562.
Sessier D.I., Blookstone J.A., Aronson S., Berry C., Gan T., Kellum J.A., Plumb J., Mythen M.G., Grocott M.P.W., Edwards M.R., Miller T.E., Miller T.E., Mythen M.G., Grocott M.P.W., Edward M.R., Ackland G.L., Brudney C.S., Cecconi M., Ince C., Irwin M.G., Lacey J., Pinsky M.R., Sanders R., Hughes F., Bader A., Thompson A., Hoeft A., Williams D., Shaw A.D., Sessler D.I., Aronson S., Berry C., Gan T.J., Kellum J., Plumb J., Bloomstone J., McEvoy M.D., Thacker J.K.M., Gupta R., Koepke E., Feldheiser A., Levett D., Michard F. and Hamilton M., Perioperative Quality Initiative consensus statement on intraoperative blood pressure, risk and outcomes for elective surgery, British Journal of Anaesthesia. 2019, 122: 563-574.
Wong G.T.C. and Irwin M.G., A cost comparison between total intravenous and volatile anaesthesia., Anaesthesia and Intensive Care. 2018, 46: 633-634.
Wong G.T.C. and Irwin M.G., In reply, Anaesthesia and Intensive Care. 2018, 46(6): 633-634.
Wong S.C.S., Choi S.W., Lee Y., Irwin M.G. and Cheung C.W., The analgesic effects of intraoperative total intravenous anesthesia (TIVA) with propofol versus sevoflurane after colorectal surgery, Medicine. 2018, 97: e11615.
XIE X., YAN D., Li H., Zhu Q., Li J., Fang Y.P., Cheung C.W., Irwin M.G., Xia Z. and Lian Q., Enhancement of Adiponectin Ameliorates Nonalcoholic Fatty Liver Disease via Inhibition of FoxO1 in Type I Diabetic Rats, Journal of Diabetes Research. 2018, 2018: 1-9.
YE X., Zhang D., Wang S., Irwin M.G. and Xia Z., Down-regulation of thioredoxin-interacting protein by repeated non-invasive limb ischemic preconditioning protects diabetic heart from myocardial ischemia/reperfusion injury, The FASEB Journal. 2019, 33 (Suppl1 ): 514.
Yuen V.M.Y., Cheuk D.K., Wong I.C., Lam W.W. and Irwin M.G., Oral chloral hydrate versus intranasal dexmedetomidine for sedation of children undergoing computed tomography: a multicenter study, Hong Kong Medical Journal. 2019, 25 Suppl 3(1): 27-29.


Researcher : Jin J

List of Research Outputs

Chang R.C.C., LIU Y., Chu M.T., Jin J. and Wong G.T.C., Short-term resistant exercise ameliorates cognitive dysfunction in 9-month 3xTg Mice, The 14th International Symposium on Alzheimer’s & Parkinson’s Diseases. 2019, #405.


Researcher : LIU Y

List of Research Outputs

Chang R.C.C., LIU Y., Chu M.T., Jin J. and Wong G.T.C., Short-term resistant exercise ameliorates cognitive dysfunction in 9-month 3xTg Mice, The 14th International Symposium on Alzheimer’s & Parkinson’s Diseases. 2019, #405.
HUANG C., Chu M.T., LIU Y., Chang R.C.C. and Wong G.T.C., Varenicline reduces DNA damage, tau mislocalization and post surgical cognitive impairment in aged mice, Neuropharmacology. 2018, 143: 217-227.
YOU R., LIU Y. and Chang R.C.C., A behavioral test battery for the repeated assessment of motor skills, mood, and cognition in mice, J. Vis. Exp.. 2019.
YOU R., Ho Y.S., Hung H.L.C., LIU Y., HUANG C., Chan H.N., Ho S.L., Lui S.Y., Li H.W. and Chang R.C.C., Silica nanoparticles induce neurodegeneration-like changes in behaviour, neuropathology, and affect synapse through MAPK activation, Particle Fibre Toxicology. 2018, 15: 28.


Researcher : Lee Y

List of Research Outputs

Wong S.C.S., Choi S.W., Lee Y., Irwin M.G. and Cheung C.W., The analgesic effects of intraoperative total intravenous anesthesia (TIVA) with propofol versus sevoflurane after colorectal surgery, Medicine. 2018, 97: e11615.


Researcher : Leung KMM

List of Research Outputs

Li A., Yuen V.M.Y., Goulay-Dufay S., Sheng Y., Standing J.F., Kwok P.C.L., Leung K.M.M., Leung A.S., Wong I.C.K. and Irwin M.G., Corrigendum to “Pharmacokinetic and pharmacodynamic study of intranasal and intravenous dexmedetomidine” (Br J Anaesth 2018; 120: 960–968), British Journal of Anaesthesia. 2018, 121 (3): 687.


Researcher : Li H

List of Research Outputs

TAI W.L., Pan Z., Sun L.T., Li H., GU P., Wong S.C.S., Chung S.K. and Cheung C.W., Suppression of Pax2 Attenuates Allodynia and Hyperalgesia through ET-1–ETAR–NFAT5 Signaling in a Rat Model of Neuropathic Pain, Neuroscience. 2018, 384: 139-151.
XIE X., YAN D., Li H., Zhu Q., Li J., Fang Y.P., Cheung C.W., Irwin M.G., Xia Z. and Lian Q., Enhancement of Adiponectin Ameliorates Nonalcoholic Fatty Liver Disease via Inhibition of FoxO1 in Type I Diabetic Rats, Journal of Diabetes Research. 2018, 2018: 1-9.
Xia Z. and Li H., HKU Faculty of Medicine Outstanding Research output award, HKU LKS School of Medicine. 2018.


Researcher : Liu AJ

Project Title:Investigating the therapeutic potential of human neural stem cells by suppressor of fused (SUFU) knockdown in a spinal cord injury model
Investigator(s):Liu AJ, Chan YS, Chang RCC, Cheung MCH
Department:Anaesthesiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:06/2019


List of Research Outputs

Liu A.J., Hong J.L., Cheung M.P.L. and Cheung M.C.H., SOX10 determines glial fate choice in the dorsal root ganglia through destabilisation of neurogenic 2, 6th Macau Symposium on Biomedical Sciences. 2019.


Researcher : Ng JKF

Project Title:The role of endothelial arginine, arginase and nitric oxide on dexmedetomidine induced vascular contraction
Investigator(s):Ng KFJ, Leung SWS
Department:Anaesthesiology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:06/2012




Researcher : Ng KFJ

Project Title:The role of endothelial arginine, arginase and nitric oxide on dexmedetomidine induced vascular contraction
Investigator(s):Ng KFJ, Leung SWS
Department:Anaesthesiology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:06/2012




Researcher : Ng TW

List of Research Outputs

HUANG C., Ng T.W., Irwin M.G., Hu X., Zhu S., Chang R.C.C. and Wong G.T.C., Differential effects of propofol and dexmedetomidine on neuroinflammation induced by systemic endotoxin lipopolysaccharides in adult mice, Australian and New Zealand College of Anaesthetists and Faculty of Pain Medicine ASM 2019.


Researcher : Pan Z

List of Research Outputs

TAI W.L., Pan Z., Sun L.T., Li H., GU P., Wong S.C.S., Chung S.K. and Cheung C.W., Suppression of Pax2 Attenuates Allodynia and Hyperalgesia through ET-1–ETAR–NFAT5 Signaling in a Rat Model of Neuropathic Pain, Neuroscience. 2018, 384: 139-151.


Researcher : QIU Q

List of Research Outputs

Wong S.C.S., Sun L.T., QIU Q., GU P., Li Q., Wang X.M.A. and Cheung C.W., Propofol attenuates postoperative hyperalgesia via regulating spinal GluN2B-p38MAPK/EPAC1 pathway in an animal model of postoperative pain, European Journal of Pain. 2018.


Researcher : Rodrigo MRC

Project Title:4th South Asian Confederation of Anaesthesiologists Congress Anaesthesia for Orthognathic Surgery
Investigator(s):Rodrigo MRC
Department:Anaesthesiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:09/1999


Project Title:The Association of Dental Anaesthetists 25th Anniversary Summer Scientific Meeting Patient Controlled Sedation with Propolfol
Investigator(s):Rodrigo MRC
Department:Anaesthesiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2002




Researcher : Sun LT

List of Research Outputs

TAI W.L., Pan Z., Sun L.T., Li H., GU P., Wong S.C.S., Chung S.K. and Cheung C.W., Suppression of Pax2 Attenuates Allodynia and Hyperalgesia through ET-1–ETAR–NFAT5 Signaling in a Rat Model of Neuropathic Pain, Neuroscience. 2018, 384: 139-151.
Wong S.C.S., Sun L.T., QIU Q., GU P., Li Q., Wang X.M.A. and Cheung C.W., Propofol attenuates postoperative hyperalgesia via regulating spinal GluN2B-p38MAPK/EPAC1 pathway in an animal model of postoperative pain, European Journal of Pain. 2018.


Researcher : TAI WL

List of Research Outputs

TAI W.L., Yeung S.C. and Cheung C.W., Enriched Environment And Effects On Neuropathic Pain: Experimental Findings And Mechanisms, Pain Practice. 2018, 18: 1068-1082.
TAI W.L., Pan Z., Sun L.T., Li H., GU P., Wong S.C.S., Chung S.K. and Cheung C.W., Suppression of Pax2 Attenuates Allodynia and Hyperalgesia through ET-1–ETAR–NFAT5 Signaling in a Rat Model of Neuropathic Pain, Neuroscience. 2018, 384: 139-151.


Researcher : Tsai NWP

List of Research Outputs

Ip K.Y., Tsai N.W.P. and Irwin M.G., Peri-operative optimization of elderly patients: a narrative review., anaethesia. 2019, 74 (Suppl 1): 80-89.
Ip K.Y., Tsai N.W.P. and Irwin M.G., Pre-operative cardiac optimization: a directed review, Anaesthesia. 2019, 74 (Suppl 1): 67-69.
Tsai N.W.P., Leung Y.M., Yeung P.N.P., Liong T.I.N.G., Lee S.F., Ngai C.W., Sin W.C., Koo J. and Chan W.M., Attitudes of visitors at adult intensive care unit toward organ donation and organ support, Chinese Medical Journal. 2019, 132: 373-376.


Researcher : Wang S

List of Research Outputs

YE X., Zhang D., Wang S., Irwin M.G. and Xia Z., Down-regulation of thioredoxin-interacting protein by repeated non-invasive limb ischemic preconditioning protects diabetic heart from myocardial ischemia/reperfusion injury, The FASEB Journal. 2019, 33 (Suppl1 ): 514.


Researcher : Wang XMA

List of Research Outputs

Leorey N S., Nada L., Zhang J.Z., Cheung C.W. and Wang X.M.A., Altered Cd8+ T Lymphocyte Response Triggered By Arginase 1: Implication For Fatigue Intensification During Localized Radiation Therapy In Prostate Cancer Patients, Neuropsychiatry. 2018, 08.
Pan Z.Q., Shan Q., GU P., Wang X.M.A., Tai W., Sun M.L., Luo X., Sun L.T. and Cheung C.W., miRNA-23a/CXCR4 regulates neuropathic pain via directly targeting TXNIP/NLRP3 inflammasome axis, Journal of Neuroinflammation. 2018, 15.
Wong S.C.S., Sun L.T., QIU Q., GU P., Li Q., Wang X.M.A. and Cheung C.W., Propofol attenuates postoperative hyperalgesia via regulating spinal GluN2B-p38MAPK/EPAC1 pathway in an animal model of postoperative pain, European Journal of Pain. 2018.


Researcher : Wong GTC

Project Title:The cardiac preconditioning effect of surgery patients
Investigator(s):Wong GTC, Irwin MG, Hiong YT, Das SR
Department:Anaesthesiology
Source(s) of Funding:Queen Mary Hospital Charitable Trust - Training and Research Assistance Scheme
Start Date:10/2007


Project Title:The impact of preoperative and postoperative haemoglobin level on rehabilitation duration in fracture hip patients
Investigator(s):Wong GTC, Leung FKL
Department:Anaesthesiology
Source(s) of Funding:AOTrauma
Start Date:09/2014


Project Title:The role of surgery induced type 1 interferon on blood brain barrier dysfunction and postoperative cognitive dysfunction
Investigator(s):Wong GTC, Chang RCC
Department:Anaesthesiology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:06/2017
Completion Date:10/2019


Project Title:ANZCA ASM 2019; Differential effects of propofol and dexmedetomidine on neuroinflammation induced by systemic endotoxin lipopolysaccharides in adult mice
Investigator(s):Wong GTC
Department:Anaesthesiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:04/2019


List of Research Outputs

Chang R.C.C., LIU Y., Chu M.T., Jin J. and Wong G.T.C., Short-term resistant exercise ameliorates cognitive dysfunction in 9-month 3xTg Mice, The 14th International Symposium on Alzheimer’s & Parkinson’s Diseases. 2019, #405.
Chen K., Wang L., Wang Q., Liu X., Lu Y., Li Y. and Wong G.T.C., Effects of pneumoperitoneum and steep Trendelenburg position on cerebral hemodynamics during robotic-assisted laparoscopic radical prostatectomy, Medicine. 2019, 98: e15794.
Cheung V., Yuen V.M.Y., Wong G.T.C. and Choi S.W., The effect of sleep deprivation and disruption on DNA damage and health of doctors, Anaesthesia. 2019, 74: 434-440.
Choi S.W. and Wong G.T.C., Assumptions and associations under pressure, Anaesthesia. 2018, 73: 901-903.
Choi S.W. and Wong G.T.C., Doctor, why are you driving a wedge between us? Calculating sample size in multiple testing and the need for Geisser-Greenhouse correction, Anaesthesia. 2018, 73: 1564-1566.
Choi S.W. and Wong G.T.C., Quality improvement studies - pitfalls of the before and after study design, Anaesthesia. 2018, 73: 1432-1435.
HUANG C., Ng T.W., Irwin M.G., Hu X., Zhu S., Chang R.C.C. and Wong G.T.C., Differential effects of propofol and dexmedetomidine on neuroinflammation induced by systemic endotoxin lipopolysaccharides in adult mice, Australian and New Zealand College of Anaesthetists and Faculty of Pain Medicine ASM 2019.
HUANG C., Chu M.T., LIU Y., Chang R.C.C. and Wong G.T.C., Varenicline reduces DNA damage, tau mislocalization and post surgical cognitive impairment in aged mice, Neuropharmacology. 2018, 143: 217-227.
Irwin M.G. and Wong G.T.C., Taking on TIVA. Why we need guidelines on total intravenous anaesthesia, Anaesthesia. 2019, 74: 140-142.
Wong G.T.C. and Irwin M.G., A cost comparison between total intravenous and volatile anaesthesia., Anaesthesia and Intensive Care. 2018, 46: 633-634.
Wong G.T.C., An Evaluaqon Of A Self-directed Peer supported Model With Structured Roles For Clinical Skills Acquisition, 10th ASIAN MEDICAL EDUCATION ASSOCIATION(AMEA) SYMPOSIUM 4th Industrial Revolution: Creating A New World for Health Professions Education. (12 - 14 April 2019). 2019.
Wong G.T.C. and Irwin M.G., In reply, Anaesthesia and Intensive Care. 2018, 46(6): 633-634.
Wong G.T.C., Monitoring during Anaesthesia can help to reduce post-operative delirium and cognitive dysfunction, 9th Asia Anaesthesia Forum Hanoi. 2018.
Wong G.T.C., Re-imaging the undergraduate medical curriculum: Enrichment Year at The University of Hong Kong, Inje University College of Medicine’s 40th Anniversary International Symposium 2019. 2019.
Wong G.T.C., Taking a new perspective Using Desflurane to achieve quality anaesthesia, Anesthesia Expert Forum Incheon Korea. 2018.
Xiong W., Zhao G.D., Yin X., Linghu K.G., Chu M.T., Wong G.T.C., Li H., Yu H. and Wang Y.T., Brij-grafted-chitosan copolymers with function of P-glycoprotein modulation: Synthesis, characterization and in vitro investigations, Carbohydrate Polymers. 2019, 204: 89-96.


Researcher : Wong K

List of Research Outputs

Chow W.C., Cheng K.S., Leong F., Cheung C.W., Shiao L.R., Leung Y.M. and Wong K., Enhancing Tetrandrine Cytotoxicity In Human Lung Carcinoma A549 Cells By Suppressing Mitochondrial Atp Production, Naunyn-schmiedeberg's Archives Of Pharmacology. 2019, 392: 427-436.


Researcher : Wong SCS

Project Title:IASP World Congress on Pain 2018; Effects of infraclavicular nerve block versus general anaesthesia for acute postoperative pain after distal radial fracture surgery/Intraoperative Total Intravenous Anaesthesia with propofol is associated reduced postoperative opioid consumption after colorectal surgery
Investigator(s):Wong SCS
Department:Anaesthesiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:09/2018
Completion Date:09/2018


Project Title:Effect of intraoperative total intravenous anaesthesia with propofol versus inhalational anaesthesia on postoperative pain after hepatectomy: a randomized controlled trial
Investigator(s):Wong SCS, Cheung CW
Department:Anaesthesiology
Source(s) of Funding:Health and Medical Research Fund - Mini Grant
Start Date:05/2019


List of Research Outputs

TAI W.L., Pan Z., Sun L.T., Li H., GU P., Wong S.C.S., Chung S.K. and Cheung C.W., Suppression of Pax2 Attenuates Allodynia and Hyperalgesia through ET-1–ETAR–NFAT5 Signaling in a Rat Model of Neuropathic Pain, Neuroscience. 2018, 384: 139-151.
Wong S.C.S., Chan T.C.W., Chung Y.F., Fang C.X. and Cheung C.W., Effects of Infraclavicular nerve block versus General Anaesthesia for Acute postoperative pain after distal radial fracture surgery, 17th World Congress on Pain (2018), Boston, USA. 2018.
Wong S.C.S., Choi S.W. and Cheung C.W., Intraoperative Total Intravenous Anaesthesia is associated with reduced postoperative opioid consumption after colorectal surgery., 17th World Congress on Pain (2018), Boston, USA. 2018.
Wong S.C.S., Sun L.T., QIU Q., GU P., Li Q., Wang X.M.A. and Cheung C.W., Propofol attenuates postoperative hyperalgesia via regulating spinal GluN2B-p38MAPK/EPAC1 pathway in an animal model of postoperative pain, European Journal of Pain. 2018.
Wong S.C.S., Choi S.W., Lee Y., Irwin M.G. and Cheung C.W., The analgesic effects of intraoperative total intravenous anesthesia (TIVA) with propofol versus sevoflurane after colorectal surgery, Medicine. 2018, 97: e11615.
Wong S.C.S., Leung M.Y.Y. and Cheung C.W., The effect of total intravenous anaesthesia with propofol on postoperative pain after third molar surgery: a double blind randomized controlled trial, European Journal of Pain. 2018.


Researcher : Wong TM

Project Title:First Asia-Pacific Opioid Symposium Cardioprotective Effects of K-Opioids
Investigator(s):Wong TM
Department:School of Biomedical Sciences
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:08/2000


Project Title:Outstanding Research Student Supervisor Award 2001-2002
Investigator(s):Wong TM
Department:Anaesthesiology
Source(s) of Funding:Outstanding Research Student Supervisor Award
Start Date:06/2002


Project Title:XVIII World Congress International Society for Heart Research in Conjunction with 52nd Annual Scientific Meeting of the Cardiac Society of Australia & New Zealand Delayed Cardioprotection of Kappa Opioid Receptor Stimulation in Normal and Diabetic Rats - Roles of Heat Shock Protein 70 and Intracellular Ca2+
Investigator(s):Wong TM
Department:School of Biomedical Sciences
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:08/2004


Project Title:CSANZ 2006 Annual Scientific Meeting Heat Shock Protein 70, Calcium Regulation and Cardiac Survival
Investigator(s):Wong TM
Department:School of Biomedical Sciences
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:08/2006




Researcher : XIE X

List of Research Outputs

XIE X., YAN D., Li H., Zhu Q., Li J., Fang Y.P., Cheung C.W., Irwin M.G., Xia Z. and Lian Q., Enhancement of Adiponectin Ameliorates Nonalcoholic Fatty Liver Disease via Inhibition of FoxO1 in Type I Diabetic Rats, Journal of Diabetes Research. 2018, 2018: 1-9.


Researcher : Xia Z

Project Title:Nitrate tolerance compromises propofol protection of the endothelium against inflammation: The role of PKC-beta2 and NADPH oxidase interaction
Investigator(s):Xia Z
Department:Anaesthesiology
Source(s) of Funding:SCA Research Starter and MidCareer Grants
Start Date:07/2008


Project Title:Experimental Biology 2015; Dexmedetomidine enhances cerebral cortex GIRK1 protein expression and attenuates Acute Postoperative Pain in rats.
Investigator(s):Xia Z
Department:Anaesthesiology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:03/2015


Project Title:Sevoflurance cardiopulmonary protection and mechanism
Investigator(s):Xia Z
Department:Anaesthesiology
Source(s) of Funding:The First Hospital of Jilin University
Start Date:08/2015


Project Title:PKCß2 over-activation reduces cardiac tolerance to ischemia-reperfusion injury in diabetic rodents by downregulating caveolin-3 and modulating cardiomyocyte autophagy
Investigator(s):Xia Z, Xu A, Vanhoutte PMGR, Wang JJ, Irwin MG
Department:Anaesthesiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:09/2015
Completion Date:08/2018


Project Title:PKCε over-activation by down-regulating caveolin-3 compromises adiponectin-mediated ischemic postconditioning cardioprotection in diabetes
Investigator(s):Xia Z, Irwin MG, Vanhoutte PMGR, Xu A
Department:Anaesthesiology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:04/2016
Completion Date:07/2018


Project Title:PKC-ϵ facilitates adiponectin to restore diabetic heart responsiveness to ischemic postconditioning: The importance of PKC-ϵ/Cav3 association.
Investigator(s):Xia Z, Vanhoutte PMGR, Xu A, Irwin MG
Department:Anaesthesiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2017


Project Title:Brg1 by down-regulating lncCNIF-mediated necroptosis restores sevoflurane postconditioning cardioprotection in diabetes
Investigator(s):Xia Z, Xu A, Irwin MG, Li H
Department:Anaesthesiology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:04/2017


Project Title:Repressor activator protein 1 protects against mitochondrial function and ischemia/reperfusion injury in aging heart via PGC1α signaling activation
Investigator(s):Xia Z, Irwin MG, Wong GTC, Cai Y, Xu A
Department:Anaesthesiology
Source(s) of Funding:Seed Fund for Basic Research
Start Date:05/2018


Project Title:Role of Cardiac STAT5A in repeated non-invasive limb ischemic preconditioning-induced cardioprotection in diabetes and its interplay with STAT3
Investigator(s):Xia Z, Xu A
Department:Anaesthesiology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:08/2018


Project Title:Deletion of Telomere-Rap1 increases the susceptibility to myocardial ischemia/reperfusion injury via p53-PGC1α signaling during aging
Investigator(s):Xia Z, Xu A, Yan B, Irwin MG
Department:Anaesthesiology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2019


List of Research Outputs

HE Y., Cai Y., Liu H., Irwin M.G. and Xia Z., Overexpression of miR-503-5p exacerbates hypoxia/reoxygenation injury in H9C2 cardiomyocytes, 2019, 33 (Supp 1): 674.
XIE X., YAN D., Li H., Zhu Q., Li J., Fang Y.P., Cheung C.W., Irwin M.G., Xia Z. and Lian Q., Enhancement of Adiponectin Ameliorates Nonalcoholic Fatty Liver Disease via Inhibition of FoxO1 in Type I Diabetic Rats, Journal of Diabetes Research. 2018, 2018: 1-9.
Xia Z., Cognitive dysfunction after cardiac surgery: controversial and potential role and mechanism of remote ischemic preconditioning, International Chinese Anesthesiologist Association (ICAA) Annual Scientific Symposium at San Francisco, USA. 2018.
Xia Z. and Li H., HKU Faculty of Medicine Outstanding Research output award, HKU LKS School of Medicine. 2018.
YE X., Zhang D., Wang S., Irwin M.G. and Xia Z., Down-regulation of thioredoxin-interacting protein by repeated non-invasive limb ischemic preconditioning protects diabetic heart from myocardial ischemia/reperfusion injury, The FASEB Journal. 2019, 33 (Suppl1 ): 514.


Researcher : YAN D

List of Research Outputs

XIE X., YAN D., Li H., Zhu Q., Li J., Fang Y.P., Cheung C.W., Irwin M.G., Xia Z. and Lian Q., Enhancement of Adiponectin Ameliorates Nonalcoholic Fatty Liver Disease via Inhibition of FoxO1 in Type I Diabetic Rats, Journal of Diabetes Research. 2018, 2018: 1-9.


Researcher : YE X

List of Research Outputs

YE X., Zhang D., Wang S., Irwin M.G. and Xia Z., Down-regulation of thioredoxin-interacting protein by repeated non-invasive limb ischemic preconditioning protects diabetic heart from myocardial ischemia/reperfusion injury, The FASEB Journal. 2019, 33 (Suppl1 ): 514.


Researcher : Yuen VMY

List of Research Outputs

Cheung V., Yuen V.M.Y., Wong G.T.C. and Choi S.W., The effect of sleep deprivation and disruption on DNA damage and health of doctors, Anaesthesia. 2019, 74: 434-440.
Li A., Yuen V.M.Y., Goulay-Dufay S., Sheng Y., Standing J.F., Kwok P.C.L., Leung K.M.M., Leung A.S., Wong I.C.K. and Irwin M.G., Corrigendum to “Pharmacokinetic and pharmacodynamic study of intranasal and intravenous dexmedetomidine” (Br J Anaesth 2018; 120: 960–968), British Journal of Anaesthesia. 2018, 121 (3): 687.
Yuen V.M.Y., Cheuk D.K., Wong I.C., Lam W.W. and Irwin M.G., Oral chloral hydrate versus intranasal dexmedetomidine for sedation of children undergoing computed tomography: a multicenter study, Hong Kong Medical Journal. 2019, 25 Suppl 3(1): 27-29.


Researcher : Zhu Q

List of Research Outputs

XIE X., YAN D., Li H., Zhu Q., Li J., Fang Y.P., Cheung C.W., Irwin M.G., Xia Z. and Lian Q., Enhancement of Adiponectin Ameliorates Nonalcoholic Fatty Liver Disease via Inhibition of FoxO1 in Type I Diabetic Rats, Journal of Diabetes Research. 2018, 2018: 1-9.


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