DEPT OF PHARMACOLOGY & PHARMACY
| Researcher : Anand S |
| List of Research Outputs |
| Lam L., Anand S., Li X., Tse M.L., Zhao J. and Chan E.W.Y., Efficacy and safety of naltrexone for amfetamine and methamfetamine use disorder: A systematic review of randomized controlled trials. , Clin Toxicology. 2018, 57(4): 225-233. |
| Researcher : Au CM |
| List of Research Outputs |
| Cheng V.K., Au C.M., Tan K.C.B. and Cheung C.L., MicroRNA and Human Bone Health, JBMR Plus. 2019, 3(1): 2-13. |
| Cheung C.L., Tan K.C.B., Au C.M., Li H.Y. and Cheung B.M.Y., Evaluation of GDF15 as a therapeutic target of cardiometabolic diseases in human: A Mendelian randomization study, EBioMedicine. 2019, 41: 85-90. |
| Researcher : BLAIS JE |
| List of Research Outputs |
| BLAIS J.E., Chan E.W.Y., Law W.Y., Mok M.T., Huang D., Wong I.C.K. and Siu D.C.W., Trends in statin prescription prevalence, initiation, and dosing: Hong Kong, 2004–2015, Atherosclerosis. 2018, 280: 174-182. |
| Li X., BLAIS J.E., Wong I.C.K., Tam A.W., Cowling B.J., Hung F.N.I. and Chan E.W.Y., Population-based estimates of the burden of pneumonia hospitalizations in Hong Kong, 2011–2015. , Eur J Clin Microbiol Infect Dis. 2019, 38(3): 553-561. |
| Researcher : Bai B |
| List of Research Outputs |
| Sun W.Y., Bai B., Luo C., Yang K., LI D., Wu D., Feletou M., Villeneuve N., Zhou Y., Yang J., Xu A., Vanhoutte P.M.G.R. and Wang Y., Lipocalin-2 derived from adipose tissue mediates aldosterone-induced renal injury, Journal of Clinical Investigation Insight. 2018, 3(17): e120196. |
| Researcher : Baretella OM |
| List of Research Outputs |
| Baretella O.M., Xu A. and Vanhoutte P.M.G.R., No Protective Effect of Constitutive Activation of AMPK in Endothelial Cells on Vascular Function in Aged Obese Mice but Augmented α1-Adrenergic Contractions in Renal Arteries Reversible by Weight Loss, Journal of Vascular Research. 2018, 189-202. |
| Researcher : CHEN H |
| List of Research Outputs |
| CHEN H., Vanhoutte P.M.G.R. and Leung S.W.S., AMPK-activation reduces EDH-type relaxations in rat small arteries , 22nd Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine (ICSM): From Cardiovascular Science to Cardiovascular Medicine, in Conjunction with 7th Asian Preventive Cardiology & Cardiac Rehabilitation Conference, 10 Nov 2018, Hong Kong. 2018, 26: 101. |
| CHEN H., Leung S.W.S. and Vanhoutte P.M.G.R., Activation of AMPK inhibits EDH-like relaxations in rat superior mesenteric arteries, Chinese Society For Vascular Medicine, Asian Society For Vascular Biology, Shanghai, November 4, 2018. |
| CHEN H., Vanhoutte P.M.G.R. and Leung S.W.S., Activation of AMPK inhibits EDH-like relaxations in rat superior mesenteric arteries, The 8th Scientific Meeting of Asian Society for Vascular Biology (ASVB), 2 to 4 November 2018, Shanghai, China. 2018. |
| CHEN H., Vanhoutte P.M.G.R. and Leung S.W.S., Biased modulation of EDH-type relaxations by AMPK in hypertension, The 13th International Symposium on Mechanisms of Vasodilatation and 7th International Symposium on Endothelium-Dependent Hyperpolarization (MOVD/EDH 2019), 20-22 May 2019, Rotterdam, The Netherlands. 2019. |
| Researcher : CHENG KF |
| List of Research Outputs |
| CHENG K.F., Li H.Y., Tan K.C.B., Lu W.W. and Cheung C.L., AKAP11 is a positive regulator of osteoblast extracellular matrix formation and mineralization, 46th ECTS Congress, Budapest Hungary, May 11-14, 2019. |
| Researcher : CHENG Y |
| List of Research Outputs |
| CHENG Y., Vanhoutte P.M.G.R. and Leung S.W.S., Apolipoprotein E deletion protects prostacyclin receptor activation in mouse aorta, Chinese Society For Vascular Medicine, Asian Society For Vascular Biology, Shanghai, November 4, 2019. 2018. |
| CHENG Y., Vanhoutte P.M.G.R. and Leung S.W.S., Apolipoprotein E deletion protects prostacyclin receptor activation in mouse aorta, The 8th Scientific Meeting of Asian Society for Vascular Biology (ASVB), 2 to 4 November 2018, Shanghai, China. 2018. |
| CHENG Y., Vanhoutte P.M.G.R. and Leung S.W.S., Apolipoprotein E deletion protects prostacyclin receptor agonist-induced relaxations in mouse aorta, 18th World Congress of Basic And Clinical Pharmacology, 1-6 July 2018, Kyoto, Japan. 2018. |
| CHENG Y., Apolipoprotein E deletion protects prostacyclin receptor agonist-induced relaxations in mouse aorta, WCP2018 KYOTO 18th World Congress of Basic and Clinical Pharmacology, 1-6 Jul 2018, Kyoto International Conference Center Kyoto, Japan. 2018. |
| CHENG Y., Vanhoutte P.M.G.R. and Leung S.W.S., Apolipoprotein E favours the blunting by high-fat diet of prostacyclin receptor activation in the mouse aorta, British Journal of Pharmacology. WILEY, 2018, 175: 3453-3469. |
| CHENG Y., Dusting G.J., Vanhoutte P.M.G.R. and Leung S.W.S., Apolipoprotein E-deletion potentiates endothelium-dependent relaxations to prostacyclin receptor activation in the mouse aorta, 13th International Symposium on Mechanisms of Vasodilatation and 7th International Symposium on Endothelium-Dependent Hyperpolarization (MOVD/EDH 2019), 20-22 May 2019, Rotterdam, The Netherlands. 2019. |
| CHENG Y., Dusting G., Vanhoutte P.M.G.R. and Leung S.W.S., Apolipoprotein E-deletion potentiates endothelium-dependent relaxations to prostacyclin receptor activation in the mouse aorta, 13th MOVD / 7th EDH 2019, Rotterdam, The Netherlands May 20-22, 2019. |
| Researcher : CHEONG LY |
| List of Research Outputs |
| CHEONG L.Y., Wang B., Shu L., WU X., Hoo R.L.C. and Xu A., Absence of inguinal lymph nodes impairs the browning of subcutaneous white adipose tissue in mice , 2018 FASEB Science Research Conferences - Immunological Aspects of Metabolic Syndrome . 2018. |
| CHEONG L.Y., Wang B., Shu L., Wu X., Hoo R.L.C. and Xu A., Absence of inguinal lymph nodes impairs the browning of subcutaneous white adipose tissue in mice, FASEB Science Research Conferences, 10-15 Aug 2018, Snowmass, CO. 2018. |
| Shu L., WU X., CHEONG L.Y., Zhou Z., Hoo R.L.C., Lam K.S.L. and Xu A., FABP4 mediates autoimmune destruction of beta cells by enhancing the crosstalk between innate and adaptive immunity/ Oral presentation, Asia Islet Biology and Incretin Symposium (AIBIS 2018). 2018. |
| Researcher : CHEUNG J |
| List of Research Outputs |
| CHEUNG J., YIU J.H.C., FUNG W.L., Xu A. and Woo W.H.C., High Fat Diet Protects Against radiation-Induced Damage: a potential benefit from Gut Microbiota, Keystone Symposia on Molecular and Cellular Biology, March 10-14, 2019, Montreal, Quebec, Canada. 2019. |
| Researcher : CHOW YT |
| List of Research Outputs |
| CHOW Y.T., LEUNG S.S.K. and Lam J.K.W., Preparation and characterisation of siRNA-containing microparticles intended for inhalation with mannitol and albumin using spray drying technique, Journal of Aerosol Medicine and Pulmonary Drug Delivery. 2019, 32: A10. |
| LIAO Q., YIP L., Chow Y.T., Chow S.F., Chan H.K., Kwok P.C.L. and Lam J.K.W., Porous and highly dispersible voriconazole dry powders produced by spray freeze drying for pulmonary delivery with efficient lung deposition, International Journal of Pharmaceutics. 2019, 560: 144-154. |
| Liang W., Chow Y.T., Chow S.F., Chan H.K., Kwok P.C.L. and Lam J.K.W., Using two-fluid nozzle for spray freeze drying to produce porous powder formulation of naked siRNA for inhalation, International Journal of Pharmaceutics. 2018, 552: 67-75. |
| Researcher : Chan EW |
| Project Title: | Young adult patient experiences in clinical management of ADHD in Hong Kong |
| Investigator(s): | Chan EWY |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Janssen Pharmaceutica - General Award |
| Start Date: | 01/2014 |
| Project Title: | Intramuscular olanzapine versus haloperidol or midazolam for the management of acute agitation in the emergency department a multicentre randomised clinical trial. |
| Investigator(s): | Chan EWY |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Early Career Scheme (ECS) |
| Start Date: | 01/2014 |
| Completion Date: | 06/2019 |
| Project Title: | Oro-dispersible olanzapine (wafer) versus conventional oral haloperidol or diazepam tablets for the management of acute agitation in the Accident and Emergency Department - a multicentre randomised clinical trial. |
| Investigator(s): | Chan EWY, Leung LP |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 06/2016 |
| Completion Date: | 06/2019 |
| Project Title: | Understanding drug abuser and their healthcare pathways: Towards better management in Hong Kong |
| Investigator(s): | Chan EWY, Tam AW |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Beat Drugs Fund Association |
| Start Date: | 06/2017 |
| Project Title: | The prescribing trends and safety of biologics in Hong Kong |
| Investigator(s): | Chan EWY |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2017 |
| Completion Date: | 05/2019 |
| Project Title: | 33rd International Conference on Pharmacoepidemiology & Therapeutic Risk Management; Bleeding-related hospital admissions and 30 day readmissions with dabigatran versus warfarin in patients with nonvalavular atrial fibrillation |
| Investigator(s): | Chan EWY |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2017 |
| Project Title: | Use of targeted therapy in non-small cell lung cancer (NSCLC) |
| Investigator(s): | Chan EWY, Wong ICK |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Takeda Pharmaceuticals (HK) Ltd |
| Start Date: | 03/2018 |
| Project Title: | ISPOR Asia Pacific 2018; Budget Impact Analysis of Introducing Tofacitinib for the Treatment of Patients with Rheumatoid Arthritis in Hong Kong |
| Investigator(s): | Chan EWY |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2018 |
| Project Title: | Outstanding Young Researcher Award 2017-18 |
| Investigator(s): | Chan EWY |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Outstanding Young Researcher Award |
| Start Date: | 12/2018 |
| Project Title: | Incidence of adverse events associated with roflumilast use in patients with COPD: a population-based cohort study |
| Investigator(s): | Chan EWY, Wong ICK, Lam CLD, Suh IH |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2019 |
| List of Research Outputs |
| Chan E.W., Li X., Pathadka S. and Wong I.C.K., Budget impact analysis of introducing Tofacitinib for the treatment of patients with rheumatoid arthritis in Hong Kong, ISPOR 8th Asia-Pacific Conference, Tokyo, Japan, 8-11th September. 2018. |
| Chan E.W. and Cheung B.M.Y., Ethnic differences in response to cardiovascular drugs, In: European Society of Cardiology, The ESC textbook of cardiovascular medicine (3rd Edition). 2018. |
| Cheung K.S.M., Chan E.W., Wong A.Y., Chen L., Seto W.K.W., Wong I.C.K. and Leung W.K., Metformin Use and Gastric Cancer Risk in Diabetic Patients After Helicobacter pylori Eradication, JNCI: Journal of the National Cancer Institute. 2018. |
| Cheung K.S.M., Chen L., Chan E.W., Seto W.K.W., Wong I.C.K. and Leung W.K., Statins reduce the progression of non-advanced adenomas to colorectal cancer: a postcolonoscopy study in 187 897 patients, Gut. 2019, gutjnl-2018-317714. |
| Law W.Y., Lau C.Y., Wong I.C.K., Lip G.Y.H., Mok M.T., Siu D.C.W. and Chan E.W., Sex-based differences in outcomes of oral anticoagulation in patients with atrial fibrillation, Journal of the American College of Cardiology. 2018, 72: 271-282. |
| Raman S.R., Man K.C.K., Bahmanyar S., Berard A., Bilder S., Boukhris T., Bushnell G., Crystal S., Furu K., Kao Yang Y.H., Karlstad Ø., Kieler H., Kubota K., Lai E.C.C., Martikainen J.E., Maura G., Moore N., Montero D., Nakamura H., Neumann A., Pate V., Pottegård A., Pratt N.L., Roughead E.E., Macias Saint-Gerons D., Stürmer T., Su C.C., Zoega H., Sturkenbroom M.C.J.M., Chan E.W., Coghill D., Ip P. and Wong I.C.K., Trends in attention-deficit hyperactivity disorder medication use: a retrospective observational study using population-based databases, The Lancet Psychiatry. 2018. |
| Shi Y.M., Wong C.K.H., Man K.C.K., Chan E.W., Ho C.W., Tse T.Y.E., Wong I.C.K. and Lam C.L.K., Treatment intensification with Dipeptidylpeptidase-4 inhibitor, insulin, or Thiazolidinediones and risks of cardiovascular diseases and all-cause mortality in patients on metformin-sulfonylurea dual therapy, 14th International Symposium on Healthy Aging “Embrace the Golden Years”, Hong Kong, 2019. . |
| Sing C.W., Wong Y.S., Kiel D.P., Cheung E.Y., Lam K.Y.J., Cheung T.T., Chan E.W., Kung A.W.C., Wong I.C.K. and Cheung C.L., Association of Alendronate and Risk of Cardiovascular Events in Patients With Hip Fracture, Journal of Bone and Mineral Research. 2018, 33: 1422-1434. |
| Sing C.W., Wong A.Y., Kiel D.P., Cheung E.Y., Lam J.K., Cheung T.T., Chan E.W., Kung A.W.C., Wong I.C.K. and Cheung C.L., Reply to: Association Between Alendronate and All-Cause Mortality and Cardiovascular Mortality Among Hip Fracture: An Alternative Explanation, J Bone Miner Res. 2018, 33(10): 1908-1909. |
| Researcher : Chan EWY |
| Project Title: | Young adult patient experiences in clinical management of ADHD in Hong Kong |
| Investigator(s): | Chan EWY |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Janssen Pharmaceutica - General Award |
| Start Date: | 01/2014 |
| Project Title: | Intramuscular olanzapine versus haloperidol or midazolam for the management of acute agitation in the emergency department a multicentre randomised clinical trial. |
| Investigator(s): | Chan EWY |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Early Career Scheme (ECS) |
| Start Date: | 01/2014 |
| Completion Date: | 06/2019 |
| Project Title: | Oro-dispersible olanzapine (wafer) versus conventional oral haloperidol or diazepam tablets for the management of acute agitation in the Accident and Emergency Department - a multicentre randomised clinical trial. |
| Investigator(s): | Chan EWY, Leung LP |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 06/2016 |
| Completion Date: | 06/2019 |
| Project Title: | Understanding drug abuser and their healthcare pathways: Towards better management in Hong Kong |
| Investigator(s): | Chan EWY, Tam AW |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Beat Drugs Fund Association |
| Start Date: | 06/2017 |
| Project Title: | The prescribing trends and safety of biologics in Hong Kong |
| Investigator(s): | Chan EWY |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2017 |
| Completion Date: | 05/2019 |
| Project Title: | 33rd International Conference on Pharmacoepidemiology & Therapeutic Risk Management; Bleeding-related hospital admissions and 30 day readmissions with dabigatran versus warfarin in patients with nonvalavular atrial fibrillation |
| Investigator(s): | Chan EWY |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2017 |
| Project Title: | Use of targeted therapy in non-small cell lung cancer (NSCLC) |
| Investigator(s): | Chan EWY, Wong ICK |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Takeda Pharmaceuticals (HK) Ltd |
| Start Date: | 03/2018 |
| Project Title: | ISPOR Asia Pacific 2018; Budget Impact Analysis of Introducing Tofacitinib for the Treatment of Patients with Rheumatoid Arthritis in Hong Kong |
| Investigator(s): | Chan EWY |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2018 |
| Project Title: | Outstanding Young Researcher Award 2017-18 |
| Investigator(s): | Chan EWY |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Outstanding Young Researcher Award |
| Start Date: | 12/2018 |
| Project Title: | Incidence of adverse events associated with roflumilast use in patients with COPD: a population-based cohort study |
| Investigator(s): | Chan EWY, Wong ICK, Lam CLD, Suh IH |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2019 |
| List of Research Outputs |
| BLAIS J.E., Chan E.W.Y., Law W.Y., Mok M.T., Huang D., Wong I.C.K. and Siu D.C.W., Trends in statin prescription prevalence, initiation, and dosing: Hong Kong, 2004–2015, Atherosclerosis. 2018, 280: 174-182. |
| Chan E.W.Y., Gold Medallion: Faculty Teaching Medal, Faculty of Medicine, The University of Hong Kong. 2018. |
| Chan E.W.Y., In-patient Medication Order Entry System (IPMOE) and technological advancements in Hong Kong, American College of Clinical Pharmacy (ACCP) Global Conference on Clinical Pharmacy, Seattle, Washington, USA. 2018. |
| Chan E.W.Y., Outstanding Young Researcher Award, The University of Hong Kong. 2018. |
| Cheung C.L., Sing C.W., Wong W., Kiel D., Cheung E., Lam J., Cheung T.T., Chan E.W.Y., Kung A.W.C. and Wong I.C.K., Association of Alendronate and Risk of Cardiovascular Events in Patients with Hip Fracture., Annual Meeting of the American-Society-for-Bone-and-Mineral-Research.. 2018. |
| Cheung K.S.M., Chan E.W.Y., Wong A.S.Y., Chen L., Seto W.K.W., Wong I.C.K. and Leung W.K., Statin use and gastric cancer risk in Helicobacter pylori-eradicated patients: a territory-wide study with propensity score matching, Medical Research Conference, Hong Kong. 2019. |
| Cheung K.S.M., Chan E.W.Y., Chen L., Seto W.K.W., Wong I.C.K. and Leung W.K., Use of non-aspirin non-steroidal anti-inflammatory drugs and risk of post-colonoscopy colorectal cancer: a territory-wide study with propensity score analysis, Digestive Disease Week . 2019. |
| GUO C., Cheung K.S.M., Zhang F., Chan E.W.Y., Chen L., Wong I.C.K. and Leung W.K., Incidences, temporal trends and risks of hospitalisation for gastrointestinal bleeding in new or chronic low-dose aspirin users after treatment for Helicobacter pylori : a territory-wide cohort study , Gut. 2019, gutjnl-2019-318352. |
| GUO C., Chen L., Chan E.W.Y., Cheung K.S.M., Isshiki T., Wong I.C.K. and Leung W.K., Systematic review with meta- analysis: the risk of gastrointestinal bleeding in patients taking third-generation P2Y12 inhibitors compared with clopidogrel, Alimentary Pharmacology & Therapeutics. 2019. |
| Ge M., Man K.K., Chui S.L.C., Chan E.W.Y., Wong I.C.K. and Li X., Prevalence, Safety and Long-Term Retention Rates of Biologics in Hong Kong from 2001 to 2015, Drug Safety. 2019. |
| Huang D., Cheng Y., Wong Y.T.A., Yung S.A., Tam C.C., Chan K.W.K., Lam C.C.S., Yiu K.H., Hai S.H.J.J., Lau C.P., Chan E.W.Y., Chiang C.E., Wong K.L., Cheung T.T., Cheung B.M.Y., Feng Y.Q., Tam N., Chen J.Y., Yue W.S., Hu H.X., Chen L., Tse H.F., Chan P.H.M. and Siu D.C.W., Thrombolysis in myocardial infarction risk score for secondary prevention of recurrent cardiovascular events in a real-world cohort of post-acute myocardial infarction patients, Circulation. 2019, 83(4): 809-817. |
| Lam L., Anand S., Li X., Tse M.L., Zhao J. and Chan E.W.Y., Efficacy and safety of naltrexone for amfetamine and methamfetamine use disorder: A systematic review of randomized controlled trials. , Clin Toxicology. 2018, 57(4): 225-233. |
| Law W.Y., Lau W.C.Y., Wong I.C.K. and Chan E.W.Y., Reply: Sex-Based Differences in Outcomes of Oral Anticoagulation: Does Antiplatelet Therapy Matter?, Journal of the American College of Cardiology. 2018, 72: 2547-2548. |
| Li X., Pathadka S., Man K.K., Wong I.C.K. and Chan E.W.Y., Budget impact of introducing tofacitinib to the public hospital formulary in Hong Kong, 2017-2021., Hong Kong Med. J. . 2019, 25(3): 201-208. |
| Li X., Shami J.J.P., Suh I.H. and Chan E.W.Y., Cost-effectiveness of pneumococcal vaccination strategies in older adults of Hong Kong, ISPOR 2019. New Orleans, LA, USA, 18-22nd May . Value in Health, 2019, 22(S2): S200. |
| Li X., Wong I.C.K., McGhee S., Kwan M.Y.W., Wong C.K.H., Ip D.K.M., Chau J. and Chan E.W.Y., Mothers' preference and willingness to pay for human papillomavirus vaccination for their daughters: a discrete choice experiment, Hong Kong Med J. Hong Kong, 2018, 24(Suppl 6): S34-6. |
| Li X., BLAIS J.E., Wong I.C.K., Tam A.W., Cowling B.J., Hung F.N.I. and Chan E.W.Y., Population-based estimates of the burden of pneumonia hospitalizations in Hong Kong, 2011–2015. , Eur J Clin Microbiol Infect Dis. 2019, 38(3): 553-561. |
| Researcher : Chan WYE |
| Project Title: | Young adult patient experiences in clinical management of ADHD in Hong Kong |
| Investigator(s): | Chan EWY |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Janssen Pharmaceutica - General Award |
| Start Date: | 01/2014 |
| Project Title: | Intramuscular olanzapine versus haloperidol or midazolam for the management of acute agitation in the emergency department a multicentre randomised clinical trial. |
| Investigator(s): | Chan EWY |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Early Career Scheme (ECS) |
| Start Date: | 01/2014 |
| Completion Date: | 06/2019 |
| Project Title: | Oro-dispersible olanzapine (wafer) versus conventional oral haloperidol or diazepam tablets for the management of acute agitation in the Accident and Emergency Department - a multicentre randomised clinical trial. |
| Investigator(s): | Chan EWY, Leung LP |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 06/2016 |
| Completion Date: | 06/2019 |
| Project Title: | Understanding drug abuser and their healthcare pathways: Towards better management in Hong Kong |
| Investigator(s): | Chan EWY, Tam AW |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Beat Drugs Fund Association |
| Start Date: | 06/2017 |
| Project Title: | The prescribing trends and safety of biologics in Hong Kong |
| Investigator(s): | Chan EWY |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2017 |
| Completion Date: | 05/2019 |
| Project Title: | 33rd International Conference on Pharmacoepidemiology & Therapeutic Risk Management; Bleeding-related hospital admissions and 30 day readmissions with dabigatran versus warfarin in patients with nonvalavular atrial fibrillation |
| Investigator(s): | Chan EWY |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2017 |
| Project Title: | Use of targeted therapy in non-small cell lung cancer (NSCLC) |
| Investigator(s): | Chan EWY, Wong ICK |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Takeda Pharmaceuticals (HK) Ltd |
| Start Date: | 03/2018 |
| Project Title: | ISPOR Asia Pacific 2018; Budget Impact Analysis of Introducing Tofacitinib for the Treatment of Patients with Rheumatoid Arthritis in Hong Kong |
| Investigator(s): | Chan EWY |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2018 |
| Project Title: | Outstanding Young Researcher Award 2017-18 |
| Investigator(s): | Chan EWY |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Outstanding Young Researcher Award |
| Start Date: | 12/2018 |
| Project Title: | Incidence of adverse events associated with roflumilast use in patients with COPD: a population-based cohort study |
| Investigator(s): | Chan EWY, Wong ICK, Lam CLD, Suh IH |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2019 |
| List of Research Outputs |
| Researcher : Cheung CL |
| Project Title: | The role of Vitamin D and bone metabolism in cardiovascular events risk, an interaction or mediation? An 11 year follow-up study |
| Investigator(s): | Cheung CL, Tan KCB, Kung AWC, Cheung BMY |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 02/2015 |
| Project Title: | Pharmacogenomics Assessment of Serious Cutaneous Adverse drug reactions (PASCA): A retrospective study |
| Investigator(s): | Cheung CL, Chan CYJ, Sham PC, Cheung BMY, Wong ICK |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2015 |
| Project Title: | Metabolomic Study of Osteoporosis in Southern Chinese |
| Investigator(s): | Cheung CL |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Early Career Scheme (ECS) |
| Start Date: | 09/2016 |
| Project Title: | Identification of susceptibility genes involved in the pathogenesis and prediction of thyrotoxic periodic paralysis |
| Investigator(s): | Cheung CL |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2017 |
| Project Title: | Genetic screening service of HLA-B*38:02 in people prescribing antithyroid drug |
| Investigator(s): | Cheung CL, Tan KCB, Cheung BMY |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | S.K. Yee Medical Foundation - General Award |
| Start Date: | 03/2017 |
| Project Title: | AKAP11 as a positive regulator of osteogenesis |
| Investigator(s): | Cheung CL, Lu WW, Tan KCB |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2018 |
| Project Title: | A comprehensive program for evaluation of musculoskeletal health and pharmacist medication review |
| Investigator(s): | Cheung CL, Chu KPJ |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Beat Drugs Fund Association |
| Start Date: | 05/2018 |
| Project Title: | ASBMR 2018 Annual Meeting; Association of Alendronate and Risk of Cardiovascular Events in Patients with Hip Fracture |
| Investigator(s): | Cheung CL |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2018 |
| Project Title: | Evaluation of the role of bisphosphonates in pneumonia-related events among patients with hip fracture |
| Investigator(s): | Cheung CL |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2019 |
| Project Title: | GREM2: A novel regulator and marker of bone metabolism? |
| Investigator(s): | Cheung CL |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 05/2019 |
| List of Research Outputs |
| CHENG K.F., Li H.Y., Tan K.C.B., Lu W.W. and Cheung C.L., AKAP11 is a positive regulator of osteoblast extracellular matrix formation and mineralization, 46th ECTS Congress, Budapest Hungary, May 11-14, 2019. |
| Chan M.L., Cheung C.L., Lee C.H.A., Yeung C.Y., Siu D.C.W., Leung J.Y., Pang H.K. and Tan K.C.B., Genetic variations in familial hypercholesterolemia and cascade screening in East Asians, Mol Genet Genomic Med. 2019, 7(2): e00520. |
| Cheng V.K., Au C.M., Tan K.C.B. and Cheung C.L., MicroRNA and Human Bone Health, JBMR Plus. 2019, 3(1): 2-13. |
| Cheung C.L., Sing C.W., Wong W., Kiel D., Cheung E., Lam J., Cheung T.T., Chan E.W.Y., Kung A.W.C. and Wong I.C.K., Association of Alendronate and Risk of Cardiovascular Events in Patients with Hip Fracture., Annual Meeting of the American-Society-for-Bone-and-Mineral-Research.. 2018. |
| Cheung C.L., Tan K.C.B., Au C.M., Li H.Y. and Cheung B.M.Y., Evaluation of GDF15 as a therapeutic target of cardiometabolic diseases in human: A Mendelian randomization study, EBioMedicine. 2019, 41: 85-90. |
| Cheung C.L., Kung A.W.C. and Tan K.C.B., Serum follicle stimulating hormone is associated with reduced risk of diabetes in postmenopausal women. The Hong Kong osteoporosis study., Maturitas.. 2018, 114: 41-45. |
| Leung R.Y.H., Cheung B.M.Y., Tan K.C.B., Kung A.W.C. and Cheung C.L., 25-Hydroxyvitamin D and the risk of incident diabetes in Hong Kong Chinese, Public Health Nutrition. 2019, 1-7. |
| Leung R.Y.H., Li H.Y., Cheung B.M.Y., Tan K.C.B., Kung A.W.C. and Cheung C.L., Serum metabolomic profiling and its association with 25-hydroxyvitamin D, Clinical Nutrition. 2019. |
| Lui K.W.K., TSOI M.F., Cheung T.T., Cheung C.L. and Cheung B.M.Y., Are blood lead levels in the United States still declining? The United States National Health Nutrition and Examination Survey 1999-2016, 24th Medical Research Conference. Hong Kong, Hong Kong Medical Journal, 2019, 25(1) suppl 1: 30. |
| Sing C.W., Wong Y.S., Kiel D.P., Cheung E.Y., Lam K.Y.J., Cheung T.T., Chan E.W., Kung A.W.C., Wong I.C.K. and Cheung C.L., Association of Alendronate and Risk of Cardiovascular Events in Patients With Hip Fracture, Journal of Bone and Mineral Research. 2018, 33: 1422-1434. |
| Sing C.W., Wong A.Y., Kiel D.P., Cheung E.Y., Lam J.K., Cheung T.T., Chan E.W., Kung A.W.C., Wong I.C.K. and Cheung C.L., Reply to: Association Between Alendronate and All-Cause Mortality and Cardiovascular Mortality Among Hip Fracture: An Alternative Explanation, J Bone Miner Res. 2018, 33(10): 1908-1909. |
| So A.S.C., TSOI M.F., Cheung C.L., Lee S.W., Tsui S.H., Tam C.C. and Cheung B.M.Y., Serum beta-2 microglobulin predicts mortality after acute coronary syndrome, 24th Medical Research Confernece. Hong Kong, Hong Kong Medical Journal, 2019, 25 (1), supp 1: 38. |
| Tan K.C.B., Cheung C.L., Lee C.H.A., Lam J.K.Y., Wong Y. and Shiu S.W.M., Galectin-3 and risk of cardiovascular events and all-cause mortality in type 2 diabetes, Diabetes Metab Res Rev. 2019, 35(2): e3093. |
| Zhou X., Cheung C.L., Karasugi T., Karppinen J., Samartzis D., Hsu Y.H., Mak S.H.T., Song Y., Chiba K., Kawaguchi Y., LI Y., Chan D., Cheung K.M.C., Ikegawa S., Cheah K.S.E. and Sham P.C., Trans-ethnic polygenic analysis supports genetic overlap of lumbar disc degeneration with height, body mass index, and bone mineral density., Frontiers in Genetics. 2018. |
| Researcher : Cho CH |
| Project Title: | Advances in GI Pharmacology - From Acid Secretion to Mucosal Protection Symposium Non-ulcerogenic Dose of Dexamethasone Delays Gastric Ulcer Healing in Rats |
| Investigator(s): | Cho CH |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2004 |
| Project Title: | Adrenaline and its receptor activation on colon cancer growth |
| Investigator(s): | Cho CH |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 02/2006 |
| Researcher : Chow SF |
| List of Research Outputs |
| Chow S.F., WENG J., XUAN B. and WAN K.Y., How can the challenges faced by nanoparticle-based pulmonary drug formulations be overcome, Therapeutic Delivery. 2019. |
| LIAO Q., YIP L., Chow Y.T., Chow S.F., Chan H.K., Kwok P.C.L. and Lam J.K.W., Porous and highly dispersible voriconazole dry powders produced by spray freeze drying for pulmonary delivery with efficient lung deposition, International Journal of Pharmaceutics. 2019, 560: 144-154. |
| Liang W., Chow Y.T., Chow S.F., Chan H.K., Kwok P.C.L. and Lam J.K.W., Using two-fluid nozzle for spray freeze drying to produce porous powder formulation of naked siRNA for inhalation, International Journal of Pharmaceutics. 2018, 552: 67-75. |
| Tao J., Chow S.F. and Zheng Y., Application of flash nanoprecipitation to fabricate poorly water-soluble drug nanoparticles, Acta Pharmaceutica Sinica B. 2019, 9: 4-18. |
| WENG J., Wong S.N., Xu X., XUAN B., Wang C., Chen R., Sun C.C., Lakerveld R., Kwok P.C.L. and Chow S.F., Cocrystal Engineering of Itraconazole with Suberic acid via Rotary Evaporation and Spray Drying, Crystal Growth & Design. 2019. |
| WENG J., Wong S.N., Wan K.Y., Chow A.H.L. and Chow S.F., Comparative Evaluation of Four Structurally-Related Profens for Nanoparticle Formulation, AAPS PharmSci 360. 2018. |
| Wan K.Y., Wong S.N., Chow S.F. and Chow A.H.L., A Novel Approach for the Fabrication of Nanoparticle Agglomerates for Pulmonary Drug Delivery, AAPS PharmSci 360. 2018. |
| Wan K.Y., Wong S.N., Wong K.W., Chow S.F. and Chow A.H.L., Interplay between Amphiphilic Stabilizers and Cholesterol in the Stabilization of Itraconazole Nanoparticles Prepared by Flash Nanoprecipitation, Molecular Pharmaceutics. 2018, 16: 195-204. |
| Wong S.N., Hu S., Ng W.W., Xu X., Lai K.L., Lee T.W.Y., Chow A.H.L., Sun C.C. and Chow S.F., Cocrystallization of curcumin with benzenediols and benzenetriols via rapid solvent removal, Crystal Growth & Design. 2018, 18: 5534-5546. |
| Wong S.N., Xu X., Dattani R., Kwok P.C.L. and Chow S.F., Crystal Engineering of Novel Pharmaceutical Cocrystal of Itraconazole with Suberic Acid, AAPS PharmSci 360. 2018. |
| Xu X., Wong S.N. and Chow S.F., Characterization of Flurbiprofen-Pyrazinamide Cocrystal Formulation as Potential Combination Therapy for Treating Tuberculosis, AAPS PharmSci 360. 2018. |
| Xu X., Wong S.N., Wan K.Y. and Chow S.F., Investigation of Photostability of Curcumin via Cocrystallization with Polyphenols, AAPS PharmSci 360. 2018. |
| Researcher : Chow YT |
| List of Research Outputs |
| CHOW Y.T., LEUNG S.S.K. and Lam J.K.W., Preparation and characterisation of siRNA-containing microparticles intended for inhalation with mannitol and albumin using spray drying technique, Journal of Aerosol Medicine and Pulmonary Drug Delivery. 2019, 32: A10. |
| LIAO Q., YIP L., Chow Y.T., Chow S.F., Chan H.K., Kwok P.C.L. and Lam J.K.W., Porous and highly dispersible voriconazole dry powders produced by spray freeze drying for pulmonary delivery with efficient lung deposition, International Journal of Pharmaceutics. 2019, 560: 144-154. |
| Liang W., Chow Y.T., Chow S.F., Chan H.K., Kwok P.C.L. and Lam J.K.W., Using two-fluid nozzle for spray freeze drying to produce porous powder formulation of naked siRNA for inhalation, International Journal of Pharmaceutics. 2018, 552: 67-75. |
| Researcher : Chui SLC |
| List of Research Outputs |
| Ge M., Man K.K., Chui S.L.C., Chan E.W.Y., Wong I.C.K. and Li X., Prevalence, Safety and Long-Term Retention Rates of Biologics in Hong Kong from 2001 to 2015, Drug Safety. 2019. |
| Researcher : DETREMMERIE CMS |
| List of Research Outputs |
| DETREMMERIE C.M.S., Leung S.W.S. and Vanhoutte P.M.G.R., Activation of NQO-1 mediates the augmented contractions of isolated arteries due to biased activity of soluble guanylyl cyclase in their smooth muscle, Naunyn-Schmiedeberg's Archives of Pharmacology. 2018, 391: 1221-1235. |
| Leung S.W.S., Detremmerie C.M.S. and Vanhoutte P.M.G.R., Biased activation of soluble guanylyl cyclase by quinones causes contractions of isolated arteries: Role of NADPH:quinone oxidoreductase-1, 18th World Congress of Basic And Clinical Pharmacology, 1-6 July 2018, Kyoto, Japan. 2018. |
| Researcher : Detremmerie CMS |
| List of Research Outputs |
| DETREMMERIE C.M.S., Leung S.W.S. and Vanhoutte P.M.G.R., Activation of NQO-1 mediates the augmented contractions of isolated arteries due to biased activity of soluble guanylyl cyclase in their smooth muscle, Naunyn-Schmiedeberg's Archives of Pharmacology. 2018, 391: 1221-1235. |
| Leung S.W.S., Detremmerie C.M.S. and Vanhoutte P.M.G.R., Biased activation of soluble guanylyl cyclase by quinones causes contractions of isolated arteries: Role of NADPH:quinone oxidoreductase-1, 18th World Congress of Basic And Clinical Pharmacology, 1-6 July 2018, Kyoto, Japan. 2018. |
| Researcher : Dufay S |
| Project Title: | Quantitation of Dexmedetomidine in plasma for pharmacokinetic study after intranasal administration in healthy volunteers |
| Investigator(s): | Dufay S, Irwin MG, Wong ICK |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2013 |
| Researcher : FUNG WL |
| List of Research Outputs |
| CHEUNG J., YIU J.H.C., FUNG W.L., Xu A. and Woo W.H.C., High Fat Diet Protects Against radiation-Induced Damage: a potential benefit from Gut Microbiota, Keystone Symposia on Molecular and Cellular Biology, March 10-14, 2019, Montreal, Quebec, Canada. 2019. |
| Researcher : Ge M |
| List of Research Outputs |
| Ge M., Man K.K., Chui S.L.C., Chan E.W.Y., Wong I.C.K. and Li X., Prevalence, Safety and Long-Term Retention Rates of Biologics in Hong Kong from 2001 to 2015, Drug Safety. 2019. |
| Researcher : Guo Y |
| List of Research Outputs |
| Guo Y., Man W.C.A., Luo C., Huang Y., Xu A., Vanhoutte P.M.G.R. and Wang Y., SIRT1 prevents age-induced impairment of vasodilator responses by enhancing the expression and activity of soluble guanylyl cyclase, Cardiovascular Research . 2018. |
| Researcher : Ho YW |
| List of Research Outputs |
| REN W., Cai Y., Zhang Y., Ho Y.W., Lam J.K.W., Vanhoutte P.M.G.R. and Leung S.W.S., MicroRNA-17-3p blunts endothelial responses to inflammatory stimuli, 13th MOVD / 7th EDH 2019, Rotterdam, The Netherlands, May 20-22, 2019. |
| Researcher : Hoo RLC |
| Project Title: | The inter-relationship between A-FABF, endoplasmic reticulum stress and autophagy in the pathogenesis of obesity-induced imflammation |
| Investigator(s): | Hoo RLC, Zhang J |
| Department: | Medicine |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2013 |
| Project Title: | Adipocyte fatty acid binding protein (A-FABP) is a potential therapeutic target of both alcoholic and non-alcoholic steatohepatitis |
| Investigator(s): | Hoo RLC, Xu A |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2015 |
| Project Title: | Adipocyte fatty acid binding protein (A-FABP) is a pathological mediator of obesity-related renal dysfunction. |
| Investigator(s): | Hoo RLC, Xu A |
| Department: | Medicine |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 06/2016 |
| Completion Date: | 02/2019 |
| Project Title: | The role of lipid chaperone ap2 in regional adipose tissue expandability |
| Investigator(s): | Hoo RLC, Xu A |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 04/2017 |
| Completion Date: | 03/2019 |
| Project Title: | The roles of neutrophil elastase (NE) and proteinase 3 (PR3) in the conversion of white to brown adipocytes |
| Investigator(s): | Hoo RLC, Xu A |
| Department: | Medicine |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2018 |
| Project Title: | Neutrophil serine proteases as the endogenous suppressors of white adipose tissue browning and adaptive thermogenesis |
| Investigator(s): | Hoo RLC, Xu A |
| Department: | Medicine |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2019 |
| Project Title: | The role of Syndecan-4 (Sdc4) in adipose tissue dysfunction |
| Investigator(s): | Hoo RLC, Xu A |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2019 |
| Project Title: | Mitochondrial protein coiled-coil-helix-coiled-coil-helix domain 10 (Chchd10) as a novel factor for the treatment of obesity and its related diseases |
| Investigator(s): | Hoo RLC, Xu A |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 06/2019 |
| List of Research Outputs |
| CHEONG L.Y., Wang B., Shu L., WU X., Hoo R.L.C. and Xu A., Absence of inguinal lymph nodes impairs the browning of subcutaneous white adipose tissue in mice , 2018 FASEB Science Research Conferences - Immunological Aspects of Metabolic Syndrome . 2018. |
| CHEONG L.Y., Wang B., Shu L., Wu X., Hoo R.L.C. and Xu A., Absence of inguinal lymph nodes impairs the browning of subcutaneous white adipose tissue in mice, FASEB Science Research Conferences, 10-15 Aug 2018, Snowmass, CO. 2018. |
| Hoo R.L.C., Editorial board member, Frontiers of Endocrinology. 2019. |
| Pan Y., Hui X., Hoo R.L.C., Ye D., Chan C.Y.C., Feng T., Wang Y., Lam K.S.L. and Xu A., Adipocyte-secreted Exosomal Microrna-34a Inhibits M2 Macrophage Polarization To Promote Obesity-induced Adipose Inflammation, Journal of Clinical Investigation. 2019, 129: 834-849. |
| Shu L., WU X., CHEONG L.Y., Zhou Z., Hoo R.L.C., Lam K.S.L. and Xu A., FABP4 mediates autoimmune destruction of beta cells by enhancing the crosstalk between innate and adaptive immunity/ Oral presentation, Asia Islet Biology and Incretin Symposium (AIBIS 2018). 2018. |
| Shu L., Hoo R.L.C. and Xu A., Fabp4 Mediates Autoimmune Diabetes Though Activation On Macrophage And Tissue Resident Memory T Lymphocyte , Shs Young Investigator Symposium & 9th Gwanak Symposium. 2019. |
| Shu L., Hoo R.L.C. and Xu A., Fabp4 Promotes Autoimmune Diabetes Through Activation On Macrophages And Tissue Resident Memory T Lymphocytes, Shs Young Investigator Symposium. 2019. |
| Shu L., Hoo R.L.C. and Xu A., Fabp4 Promotes Autoimmune Diabetes Through Activation On Macrophages And Tissue Resident Memory T Lymphocytes, Shs Young Investigator Symposium & Gwanak Symposium. 2019. |
| Researcher : JIN L |
| List of Research Outputs |
| Geng L., Liao B., Jin L., Huang Z., Triggle C., Hong D., Zhang J., Huang Y., Lin Z. and Xu A., Exercise Alleviates Obesity-Induced Metabolic Dysfunction via Enhancing FGF21 Sensitivity in Adipose Tissues, In: Stephen Matheson, Cell Reports. Cambridge, Massachusetts, U.S., Cell Press, 2019, 26: 2738-2752.E4. |
| JIN L., High Fat Diet Protects Against radiation-Induced Damage: a potential benefit from Gut Microbiota, Keystone Symposia on Molecular and Cellular Biology, Drivers of Type 2 Diabetes: From Genes to Environment, October 7-11, 2018, Seoul, South Korea. 2018. |
| LIU Z., JIN L., Yang J.K., Wang B., Wu K.K., Hallenborg P., Xu A. and Cheng K.K., The Dysfunctional MDM2-p53 Axis in Adipocytes Contributes to Ageing Related Metabolic Complications by Induction of Lipodystrophy, Diabetes. 2018, db180684. |
| Researcher : Jin L |
| List of Research Outputs |
| Geng L., Liao B., Jin L., Huang Z., Triggle C., Hong D., Zhang J., Huang Y., Lin Z. and Xu A., Exercise Alleviates Obesity-Induced Metabolic Dysfunction via Enhancing FGF21 Sensitivity in Adipose Tissues, In: Stephen Matheson, Cell Reports. Cambridge, Massachusetts, U.S., Cell Press, 2019, 26: 2738-2752.E4. |
| JIN L., High Fat Diet Protects Against radiation-Induced Damage: a potential benefit from Gut Microbiota, Keystone Symposia on Molecular and Cellular Biology, Drivers of Type 2 Diabetes: From Genes to Environment, October 7-11, 2018, Seoul, South Korea. 2018. |
| LIU Z., JIN L., Yang J.K., Wang B., Wu K.K., Hallenborg P., Xu A. and Cheng K.K., The Dysfunctional MDM2-p53 Axis in Adipocytes Contributes to Ageing Related Metabolic Complications by Induction of Lipodystrophy, Diabetes. 2018, db180684. |
| Researcher : KONJA D |
| List of Research Outputs |
| KONJA D., ZHANG P., Luo C., Xu A., Vanhoutte P.M.G.R. and Wang Y., Overexpression of SIRT1 in perivascular adipose tissue enhances vasodilatation and prevents adverse arterial remodeling by modulating the crosstalks between mitochondria and endoplasmic reticulum, 13th MOVD /7th EDH 2019, Rotterdam, The Netherlands, May 20-22, 2019. |
| Researcher : Kwan CM |
| List of Research Outputs |
| Chesla C.A., Chun K.M. and Kwan C.M., Biculturalism in couple support for diabetes care in U.S.-born Chinese Americans, Research in Nursing & Health. 2019, 42: 39-47. |
| Researcher : Kwok PCL |
| Project Title: | Dexmedetomidine buccal spray solution for premedication in children |
| Investigator(s): | Kwok PCL, Dufay S, Yuen VMY |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Health and Medical Research Fund - Mini Grant |
| Start Date: | 05/2015 |
| Researcher : LI D |
| List of Research Outputs |
| Sun W.Y., Bai B., Luo C., Yang K., LI D., Wu D., Feletou M., Villeneuve N., Zhou Y., Yang J., Xu A., Vanhoutte P.M.G.R. and Wang Y., Lipocalin-2 derived from adipose tissue mediates aldosterone-induced renal injury, Journal of Clinical Investigation Insight. 2018, 3(17): e120196. |
| Researcher : LI J |
| List of Research Outputs |
| LI J., A new andrographolide derivative exhibited anti-colon cancer effects via anti-angiogenic and pro-apoptotic pathways, WCP 2018 KYOTO 18th World Congress of Basic and Clinical Pharmacology, 1-6 Jul 2018, Kyoto International Conference Center Kyoto, Japan. 2018. |
| LI J., Synergistic combination with oridonin enhances doxorubicin anti-tumor efficacy against aggressive breast cancer via pro-apoptosis and anti-angiogenic effects, ICMPB & SNPBR, 22-24 Aug 2018, Macao. 2018. |
| Researcher : LI R |
| List of Research Outputs |
| Cheng I.S.C., LI R., Leung G.P.H., Li S.L., Kong M., Lao L., Zhang Z., Lin W.L., Ng E.H.Y., Rong J., Chen J., Su J., Zhang Y. and Meng W., Application of UPLC‐MS/MS to simultaneously detect four bioactive compounds in the tumour‐shrinking decoction (FM1523) for uterine fibroids treatment, Phytochemical Analysis. 2019. |
| Researcher : LI Y |
| List of Research Outputs |
| LI Y. and Wang W., Photo-controlled dendrimers for cancer therapy, ICMAT 2019, June 23-28, 2019 Singapore. 2019. |
| LI Y., ZHANG Y. and Wang W., Photoresponsive nanoparticles for targeted drug delivery, 5th International Biomaterials Symposium. 2018. |
| LI Y., ZHANG Y., LONG K. and Wang W., Phototriggered targeting of nanocarriers for drug delivery, 2018 Taiwan-Japan-Korea Trilateral Conference on Nanomedicine. 2018. |
| LI Y., ZHANG Y. and Wang W., Phototriggered targeting of nanocarriers for drug delivery, Nano Research. Springer Nature, 2018, 11: 5424. |
| ZHANG Y., LI J., LI Y., GE Z. and Wang W., Stimuli-responsive polymeric nanoreactors for cancer therapy , 3rd Asian University Symposium for Biomedical Engineering. 2018. |
| Researcher : LIAO Q |
| List of Research Outputs |
| LIAO Q. and Lam J.K.W., Formulation of inhalable voriconazole dry powders using spray freeze drying technique, Journal of Aerosol Medicine and Pulmonary Drug Delivery. Mary Ann Liebert, 2019, 32: A18. |
| LIAO Q., YIP L., Chow Y.T., Chow S.F., Chan H.K., Kwok P.C.L. and Lam J.K.W., Porous and highly dispersible voriconazole dry powders produced by spray freeze drying for pulmonary delivery with efficient lung deposition, International Journal of Pharmaceutics. 2019, 560: 144-154. |
| Researcher : LONG K |
| List of Research Outputs |
| LI Y., ZHANG Y., LONG K. and Wang W., Phototriggered targeting of nanocarriers for drug delivery, 2018 Taiwan-Japan-Korea Trilateral Conference on Nanomedicine. 2018. |
| Researcher : Lam JKW |
| Project Title: | Porous nanoparticle aerosol carriers with controllable density for pulmonary drug delivery |
| Investigator(s): | Lam JKW, Kwok PCL |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2016 |
| Project Title: | Development of a highly efficient inhalable mucosal DNA vaccine against HIV as dry powder using pH responsive LAH peptides with nuclear localizing sequence as DNA carrier |
| Investigator(s): | Lam JKW, Chen Z, Kwok PCL, Lan Y, Chu YJ |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2016 |
| Project Title: | Inhalable dry powder formulation of naked siRNA using spray-drying and spray freeze-drying technologies for the treatment of respiratory infections |
| Investigator(s): | Lam JKW, Kwok PCL |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2016 |
| Project Title: | Aerosolized formulation of antifungal drugs for pulmonary fungal infections |
| Investigator(s): | Lam JKW |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2017 |
| Completion Date: | 05/2019 |
| Project Title: | Lung surfactant inspired peptide-based vector for pulmonary delivery of small nucleic acid therapeutics |
| Investigator(s): | Lam JKW |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2018 |
| Project Title: | Drug Delivery to Lungs (DDL 2018); Albumin as an alternative dispersion enhancer for inhalable siRNA spray dried powders |
| Investigator(s): | Lam JKW |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 12/2018 |
| Completion Date: | 12/2018 |
| Project Title: | High-performance inhaled powder formulation of RNAi therapeutics by co-spray drying of RNA with human serum albumin |
| Investigator(s): | Lam JKW |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2019 |
| Project Title: | Investigation of inhaled RNAi therapeutics targeting EGFR for the treatment of lung cancer |
| Investigator(s): | Lam JKW |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2019 |
| List of Research Outputs |
| CHOW Y.T., LEUNG S.S.K. and Lam J.K.W., Preparation and characterisation of siRNA-containing microparticles intended for inhalation with mannitol and albumin using spray drying technique, Journal of Aerosol Medicine and Pulmonary Drug Delivery. 2019, 32: A10. |
| LIAO Q. and Lam J.K.W., Formulation of inhalable voriconazole dry powders using spray freeze drying technique, Journal of Aerosol Medicine and Pulmonary Drug Delivery. Mary Ann Liebert, 2019, 32: A18. |
| LIAO Q., YIP L., Chow Y.T., Chow S.F., Chan H.K., Kwok P.C.L. and Lam J.K.W., Porous and highly dispersible voriconazole dry powders produced by spray freeze drying for pulmonary delivery with efficient lung deposition, International Journal of Pharmaceutics. 2019, 560: 144-154. |
| Lam J.K.W., Development of carrier-free, inhalable powder formulation of siRNA, 18th World Congress of Basic and Clinical Pharmacology, Kyoto, Japan. 2018. |
| Liang W., Chow Y.T., Chow S.F., Chan H.K., Kwok P.C.L. and Lam J.K.W., Using two-fluid nozzle for spray freeze drying to produce porous powder formulation of naked siRNA for inhalation, International Journal of Pharmaceutics. 2018, 552: 67-75. |
| Lucarini S., Fagioli L., Cavanagh R., Liang W., Perinelli D., Campana M., Stolnik S., Lam J.K.W., Casettari L. and Duranti A., Synthesis, Structure–Activity Relationships and In Vitro Toxicity Profile of Lactose-Based Fatty Acid Monoesters as Possible Drug Permeability Enhancers, Pharmaceutics. 2018, 10: 81. |
| MAN K.W.D., Kanno T., Manzo G., Robertson B.D., Lam J.K.W. and Mason A.J., Rifampin- or Capreomycin-Induced Remodeling of the Mycobacterium smegmatis Mycolic Acid Layer Is Mitigated in Synergistic Combinations with Cationic Antimicrobial Peptides , mSphere. 2018, 3: e00218-18. |
| QIU Y., TAM B., CHUNG W.Y.W., MASON A.J. and Lam J.K.W., Relationship between the secondary structure of the peptide based siRNA carrier and effective gene silencing effect on lung epithelial cells, Journal of Aerosol Medicine and Pulmonary Drug Delivery. Mary Ann Liebert, 2019, 32: A16-17. |
| REN W., Cai Y., Zhang Y., Ho Y.W., Lam J.K.W., Vanhoutte P.M.G.R. and Leung S.W.S., MicroRNA-17-3p blunts endothelial responses to inflammatory stimuli, 13th MOVD / 7th EDH 2019, Rotterdam, The Netherlands, May 20-22, 2019. |
| ZHANG L., NG T.B., Lam J.K.W., WANG S., Lao L., Zhang Y. and Sze C.W.S., Research and Development of Proteins and Peptides with Therapeutic Potential from Yam Tubers, Current Protein & Peptide Science. 2019, 20: 277-284. |
| Researcher : Lam L |
| List of Research Outputs |
| Lam L., Anand S., Li X., Tse M.L., Zhao J. and Chan E.W.Y., Efficacy and safety of naltrexone for amfetamine and methamfetamine use disorder: A systematic review of randomized controlled trials. , Clin Toxicology. 2018, 57(4): 225-233. |
| Researcher : Lam MPS |
| List of Research Outputs |
| Lam M.P.S., The Impact of Automatic Tablet Dispensing and Packaging System (ATDPS) in a Rehabilitation Complex - Preliminary results. Hong Kong, Hong Kong Pharmaceutical Journal, 2019, 26: S09. |
| Researcher : Lau CY |
| List of Research Outputs |
| Brauer R., Lau C.Y., Hayes J.F., Man K.C.K., Osborn D.P.J., Howard R., Kim J. and Wong I.C.K., Trazodone use and risk of dementia: A population-based cohort study, PLOS Medicine. 2019, 16: e1002728. |
| Law W.Y., Lau C.Y., Wong I.C.K., Lip G.Y.H., Mok M.T., Siu D.C.W. and Chan E.W., Sex-based differences in outcomes of oral anticoagulation in patients with atrial fibrillation, Journal of the American College of Cardiology. 2018, 72: 271-282. |
| Naser A.Y., Wong I.C.K., Whittlesea C., Beykloo M.Y., Man K.C.K., Lau C.Y., Hyassat D.A.H. and Wei L., Use of multiple antidiabetic medications in patients with diabetes and its association with hypoglycaemic events: a case-crossover study in Jordan, BMJ Open. 2018, 8: e024909. |
| Researcher : Law WY |
| List of Research Outputs |
| BLAIS J.E., Chan E.W.Y., Law W.Y., Mok M.T., Huang D., Wong I.C.K. and Siu D.C.W., Trends in statin prescription prevalence, initiation, and dosing: Hong Kong, 2004–2015, Atherosclerosis. 2018, 280: 174-182. |
| Law W.Y., Lau W.C.Y., Wong I.C.K. and Chan E.W.Y., Reply: Sex-Based Differences in Outcomes of Oral Anticoagulation: Does Antiplatelet Therapy Matter?, Journal of the American College of Cardiology. 2018, 72: 2547-2548. |
| Law W.Y., Lau C.Y., Wong I.C.K., Lip G.Y.H., Mok M.T., Siu D.C.W. and Chan E.W., Sex-based differences in outcomes of oral anticoagulation in patients with atrial fibrillation, Journal of the American College of Cardiology. 2018, 72: 271-282. |
| Researcher : Leung GPH |
| Project Title: | Cloning and characterization of novel equilibrative nucleoside transporter type 4 (ENT4) |
| Investigator(s): | Leung GPH |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 03/2005 |
| Project Title: | Protective effects of Pleurotus ostreatus (Oyster mushroom) and ergothioneine against doxorubicin-induced cardiotoxicity |
| Investigator(s): | Leung GPH, Xia Z, Zhang Y, So TH |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2016 |
| Completion Date: | 08/2019 |
| Project Title: | Development of novel equilibrative nucleoside transporter-2 inhibitor and its application in studying the functions of equilibrative nucleoside transporter-2 in skeletal muscle |
| Investigator(s): | Leung GPH, Ballard HJ |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2016 |
| Completion Date: | 09/2018 |
| Project Title: | Role of equilibrative nucleoside transporter-4 in ischemic brain damage |
| Investigator(s): | Leung GPH |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2017 |
| Completion Date: | 05/2019 |
| Project Title: | Role of equilibrative nucleoside transporter-4 in the cardioprotection against ischemia-reperfusion injury in diabetes mellitus |
| Investigator(s): | Leung GPH, Xia Z |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2018 |
| Project Title: | Effects of Danshensu on increasing the therapeutic to adverse effect ratio of bevacizumab |
| Investigator(s): | Leung GPH |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2018 |
| Project Title: | Development of novel selective inhibitors of equilibrative nucleoside transporter-2 through the structural modification of FPMINT and molecular docking |
| Investigator(s): | Leung GPH |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2019 |
| List of Research Outputs |
| CHEN X., ZHU S., Zhenin M., XU W., Bose S.J., Wong P.F., Leung G.P.H., Senderowitz H. and Chen J., A defective flexible loop contributes to the processing and gating defects of the predominant cystic fibrosis–causing mutation, The FASEB Journal. 2019, 33: 5126-5142. |
| CHEN X., LAM K.H., Feng Y., Xu K., Sze S.C.W., Tang S.C.W., Leung G.P.H., Lee C.K.F., Shi J., Yang Z., Li S., Zhang Z. and Zhang Y., Ellagitannins from Pomegranate Ameliorates 5-Fluorouracil-Induced Intestinal Mucositis in Rats while Enhancing Its Chemotoxicity against HT-29 Colorectal Cancer Cells through Intrinsic Apoptosis Induction, Journal of Agricultural and Food Chemistry. 2018, 66: 7054-7064. |
| Cheng I.S.C., LI R., Leung G.P.H., Li S.L., Kong M., Lao L., Zhang Z., Lin W.L., Ng E.H.Y., Rong J., Chen J., Su J., Zhang Y. and Meng W., Application of UPLC‐MS/MS to simultaneously detect four bioactive compounds in the tumour‐shrinking decoction (FM1523) for uterine fibroids treatment, Phytochemical Analysis. 2019. |
| LIU J., CHEN X., Chen H., Shi J., Leung G.P.H., Tang S.C.W., Lao L., Yip H.K.F., Lee C.K.F., Sze S.C.W., Zhang Z. and Zhang Y., Downregulation of Aquaporin 9 Exacerbates Beta-amyloid-induced Neurotoxicity in Alzheimer’s Disease Models In vitro and In vivo, Neuroscience. 2018, 394: 72-82. |
| Researcher : Leung SWS |
| Project Title: | Effects of microRNA-17-3p upregulation on vascular inflammation and endothelial dysfunction caused by the human immunodeficiency virus proteins |
| Investigator(s): | Leung SWS, Lam JKW |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 06/2017 |
| Project Title: | MicroRNA-17-3p curtails endothelial dysfunction and vascular inflammation |
| Investigator(s): | Leung SWS, Vanhoutte PMGR |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2017 |
| Completion Date: | 05/2019 |
| Project Title: | Effects of activation of adenosine monophosphate-activated protein kinase (AMPK) on endothelium-dependent hyperpolarization-like relaxations in mesenteric arteries of normotensive and hypertensive rats |
| Investigator(s): | Leung SWS, Vanhoutte PMGR |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2018 |
| Project Title: | Paradoxical vasoconstrictor effect of thymoquinone, a natural product known to induce vasodilatation and used in humans |
| Investigator(s): | Leung SWS, Leung GPH |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 06/2018 |
| Project Title: | 18th World Congress of Basic And Clinical Pharmacology (WCP2018); Biased activation of soluble guanylyl cyclase by quinones causes contractions of isolated arteries: Role of NADPH:quinone oxidoreductase-1 |
| Investigator(s): | Leung SWS |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2018 |
| Completion Date: | 07/2018 |
| Project Title: | Mechanism(s) underlying the salt-induced vascular inflammation and endothelial dysfunction |
| Investigator(s): | Leung SWS, Vanhoutte PMGR |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2019 |
| List of Research Outputs |
| CHEN H., Vanhoutte P.M.G.R. and Leung S.W.S., AMPK-activation reduces EDH-type relaxations in rat small arteries , 22nd Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine (ICSM): From Cardiovascular Science to Cardiovascular Medicine, in Conjunction with 7th Asian Preventive Cardiology & Cardiac Rehabilitation Conference, 10 Nov 2018, Hong Kong. 2018, 26: 101. |
| CHEN H., Leung S.W.S. and Vanhoutte P.M.G.R., Activation of AMPK inhibits EDH-like relaxations in rat superior mesenteric arteries, Chinese Society For Vascular Medicine, Asian Society For Vascular Biology, Shanghai, November 4, 2018. |
| CHEN H., Vanhoutte P.M.G.R. and Leung S.W.S., Activation of AMPK inhibits EDH-like relaxations in rat superior mesenteric arteries, The 8th Scientific Meeting of Asian Society for Vascular Biology (ASVB), 2 to 4 November 2018, Shanghai, China. 2018. |
| CHEN H., Vanhoutte P.M.G.R. and Leung S.W.S., Biased modulation of EDH-type relaxations by AMPK in hypertension, The 13th International Symposium on Mechanisms of Vasodilatation and 7th International Symposium on Endothelium-Dependent Hyperpolarization (MOVD/EDH 2019), 20-22 May 2019, Rotterdam, The Netherlands. 2019. |
| CHENG Y., Vanhoutte P.M.G.R. and Leung S.W.S., Apolipoprotein E deletion protects prostacyclin receptor activation in mouse aorta, Chinese Society For Vascular Medicine, Asian Society For Vascular Biology, Shanghai, November 4, 2019. 2018. |
| CHENG Y., Vanhoutte P.M.G.R. and Leung S.W.S., Apolipoprotein E deletion protects prostacyclin receptor activation in mouse aorta, The 8th Scientific Meeting of Asian Society for Vascular Biology (ASVB), 2 to 4 November 2018, Shanghai, China. 2018. |
| CHENG Y., Vanhoutte P.M.G.R. and Leung S.W.S., Apolipoprotein E deletion protects prostacyclin receptor agonist-induced relaxations in mouse aorta, 18th World Congress of Basic And Clinical Pharmacology, 1-6 July 2018, Kyoto, Japan. 2018. |
| CHENG Y., Vanhoutte P.M.G.R. and Leung S.W.S., Apolipoprotein E favours the blunting by high-fat diet of prostacyclin receptor activation in the mouse aorta, British Journal of Pharmacology. WILEY, 2018, 175: 3453-3469. |
| CHENG Y., Dusting G.J., Vanhoutte P.M.G.R. and Leung S.W.S., Apolipoprotein E-deletion potentiates endothelium-dependent relaxations to prostacyclin receptor activation in the mouse aorta, 13th International Symposium on Mechanisms of Vasodilatation and 7th International Symposium on Endothelium-Dependent Hyperpolarization (MOVD/EDH 2019), 20-22 May 2019, Rotterdam, The Netherlands. 2019. |
| CHENG Y., Dusting G., Vanhoutte P.M.G.R. and Leung S.W.S., Apolipoprotein E-deletion potentiates endothelium-dependent relaxations to prostacyclin receptor activation in the mouse aorta, 13th MOVD / 7th EDH 2019, Rotterdam, The Netherlands May 20-22, 2019. |
| DETREMMERIE C.M.S., Leung S.W.S. and Vanhoutte P.M.G.R., Activation of NQO-1 mediates the augmented contractions of isolated arteries due to biased activity of soluble guanylyl cyclase in their smooth muscle, Naunyn-Schmiedeberg's Archives of Pharmacology. 2018, 391: 1221-1235. |
| Leung S.W.S., Detremmerie C.M.S. and Vanhoutte P.M.G.R., Biased activation of soluble guanylyl cyclase by quinones causes contractions of isolated arteries: Role of NADPH:quinone oxidoreductase-1, 18th World Congress of Basic And Clinical Pharmacology, 1-6 July 2018, Kyoto, Japan. 2018. |
| Leung S.W.S., Sex differences in endothelium-dependent vasodilator signals (NO and EDH) in the progression of vascular disease, 13th International Symposium on Mechanisms of Vasodilatation and 7th International Symposium on Endothelium-Dependent Hyperpolarization (MOVD/EDH 2019), 20-22 May 2019, Rotterdam, The Netherlands. 2019. |
| Leung S.W.S., Cai Y., ZHANG Y., Vanhoutte P.M.G.R., Sun X., Feinberg M.W. and Man R.Y.K., Upregulation of miRNA-17-3p reduces inflammatory responses in rats, The 8th Scientific Meeting of Asian Society for Vascular Biology (ASVB), 2 to 4 November 2018, Shanghai, China. 2018. |
| REN W., Cai Y., Zhang Y., Ho Y.W., Lam J.K.W., Vanhoutte P.M.G.R. and Leung S.W.S., MicroRNA-17-3p blunts endothelial responses to inflammatory stimuli, 13th MOVD / 7th EDH 2019, Rotterdam, The Netherlands, May 20-22, 2019. |
| Researcher : Li HY |
| List of Research Outputs |
| CHENG K.F., Li H.Y., Tan K.C.B., Lu W.W. and Cheung C.L., AKAP11 is a positive regulator of osteoblast extracellular matrix formation and mineralization, 46th ECTS Congress, Budapest Hungary, May 11-14, 2019. |
| Cheung C.L., Tan K.C.B., Au C.M., Li H.Y. and Cheung B.M.Y., Evaluation of GDF15 as a therapeutic target of cardiometabolic diseases in human: A Mendelian randomization study, EBioMedicine. 2019, 41: 85-90. |
| Leung R.Y.H., Li H.Y., Cheung B.M.Y., Tan K.C.B., Kung A.W.C. and Cheung C.L., Serum metabolomic profiling and its association with 25-hydroxyvitamin D, Clinical Nutrition. 2019. |
| Researcher : Li X |
| Project Title: | ISPOR 2019; Cost-effectiveness of pneumococcal vaccination strategies in older adults of Hong Kong |
| Investigator(s): | Li X |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2019 |
| Completion Date: | 05/2019 |
| Project Title: | The impact of childhood pneumococcal conjugate vaccine (PCV) immunisation on pneumonia admissions in Hong Kong: a population-based interrupted time series analysis from 2004-2017 |
| Investigator(s): | Li X, Chan EWY, Hung FNI |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 06/2019 |
| List of Research Outputs |
| Chan E.W., Li X., Pathadka S. and Wong I.C.K., Budget impact analysis of introducing Tofacitinib for the treatment of patients with rheumatoid arthritis in Hong Kong, ISPOR 8th Asia-Pacific Conference, Tokyo, Japan, 8-11th September. 2018. |
| Ge M., Man K.K., Chui S.L.C., Chan E.W.Y., Wong I.C.K. and Li X., Prevalence, Safety and Long-Term Retention Rates of Biologics in Hong Kong from 2001 to 2015, Drug Safety. 2019. |
| Lam L., Anand S., Li X., Tse M.L., Zhao J. and Chan E.W.Y., Efficacy and safety of naltrexone for amfetamine and methamfetamine use disorder: A systematic review of randomized controlled trials. , Clin Toxicology. 2018, 57(4): 225-233. |
| Li X., Pathadka S., Man K.K., Wong I.C.K. and Chan E.W.Y., Budget impact of introducing tofacitinib to the public hospital formulary in Hong Kong, 2017-2021., Hong Kong Med. J. . 2019, 25(3): 201-208. |
| Li X., Shami J.J.P., Suh I.H. and Chan E.W.Y., Cost-effectiveness of pneumococcal vaccination strategies in older adults of Hong Kong, ISPOR 2019. New Orleans, LA, USA, 18-22nd May . Value in Health, 2019, 22(S2): S200. |
| Li X., Global orphan drug policy and insights for Hong Kong, Hong Kong Pharmacy Conference 2019. 2019. |
| Li X., Health economics for shared-decision making - an evaluation of NOACs in Hong Kong and Mainland China, HKU-UCL Collaboration on Medication Safety and Healthcare Big Data Research. 2018. |
| Li X., Health economics for shared-decision making - an evaluation of NOACs in Hong Kong and Mainland China, The AMHFPM Symposium on Pharmacoeconomics 2019. 2019. |
| Li X., Wong I.C.K., McGhee S., Kwan M.Y.W., Wong C.K.H., Ip D.K.M., Chau J. and Chan E.W.Y., Mothers' preference and willingness to pay for human papillomavirus vaccination for their daughters: a discrete choice experiment, Hong Kong Med J. Hong Kong, 2018, 24(Suppl 6): S34-6. |
| Li X., BLAIS J.E., Wong I.C.K., Tam A.W., Cowling B.J., Hung F.N.I. and Chan E.W.Y., Population-based estimates of the burden of pneumonia hospitalizations in Hong Kong, 2011–2015. , Eur J Clin Microbiol Infect Dis. 2019, 38(3): 553-561. |
| Li X., Updates: Health Policy Trends in Asia Pacific – Hong Kong, ISPOR 24th International annual meeting, Asian business meeting. 2019. |
| Li X., Will NOACs Increase GI Bleeding Risk? Insights from Latest Real World Evidence from HKU, Stroke from Prevention to Rehabilitation Symposium 2019, Hong Kong Geriatric Society. 2019. |
| Researcher : Liang W |
| List of Research Outputs |
| Liang W., Chow Y.T., Chow S.F., Chan H.K., Kwok P.C.L. and Lam J.K.W., Using two-fluid nozzle for spray freeze drying to produce porous powder formulation of naked siRNA for inhalation, International Journal of Pharmaceutics. 2018, 552: 67-75. |
| Lucarini S., Fagioli L., Cavanagh R., Liang W., Perinelli D., Campana M., Stolnik S., Lam J.K.W., Casettari L. and Duranti A., Synthesis, Structure–Activity Relationships and In Vitro Toxicity Profile of Lactose-Based Fatty Acid Monoesters as Possible Drug Permeability Enhancers, Pharmaceutics. 2018, 10: 81. |
| Researcher : Liao B |
| List of Research Outputs |
| Geng L., Liao B., Jin L., Huang Z., Triggle C., Hong D., Zhang J., Huang Y., Lin Z. and Xu A., Exercise Alleviates Obesity-Induced Metabolic Dysfunction via Enhancing FGF21 Sensitivity in Adipose Tissues, In: Stephen Matheson, Cell Reports. Cambridge, Massachusetts, U.S., Cell Press, 2019, 26: 2738-2752.E4. |
| Researcher : Lui WYV |
| Project Title: | A Precision Therapeutic Tool for Head and Neck Cancer (HNC) |
| Investigator(s): | Lui WYV |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Translational and Applied Research |
| Start Date: | 03/2015 |
| Project Title: | HKU Overseas Fellowship Awards 2015-16 |
| Investigator(s): | Lui WYV |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | HKU Overseas Fellowship Awards |
| Start Date: | 06/2015 |
| Researcher : Luo C |
| List of Research Outputs |
| Guo Y., Man W.C.A., Luo C., Huang Y., Xu A., Vanhoutte P.M.G.R. and Wang Y., SIRT1 prevents age-induced impairment of vasodilator responses by enhancing the expression and activity of soluble guanylyl cyclase, Cardiovascular Research . 2018. |
| KONJA D., ZHANG P., Luo C., Xu A., Vanhoutte P.M.G.R. and Wang Y., Overexpression of SIRT1 in perivascular adipose tissue enhances vasodilatation and prevents adverse arterial remodeling by modulating the crosstalks between mitochondria and endoplasmic reticulum, 13th MOVD /7th EDH 2019, Rotterdam, The Netherlands, May 20-22, 2019. |
| Sun W.Y., Bai B., Luo C., Yang K., LI D., Wu D., Feletou M., Villeneuve N., Zhou Y., Yang J., Xu A., Vanhoutte P.M.G.R. and Wang Y., Lipocalin-2 derived from adipose tissue mediates aldosterone-induced renal injury, Journal of Clinical Investigation Insight. 2018, 3(17): e120196. |
| Researcher : MAN KWD |
| List of Research Outputs |
| MAN K.W.D., Kanno T., Manzo G., Robertson B.D., Lam J.K.W. and Mason A.J., Rifampin- or Capreomycin-Induced Remodeling of the Mycobacterium smegmatis Mycolic Acid Layer Is Mitigated in Synergistic Combinations with Cationic Antimicrobial Peptides , mSphere. 2018, 3: e00218-18. |
| Researcher : Man KCK |
| List of Research Outputs |
| Brauer R., Lau C.Y., Hayes J.F., Man K.C.K., Osborn D.P.J., Howard R., Kim J. and Wong I.C.K., Trazodone use and risk of dementia: A population-based cohort study, PLOS Medicine. 2019, 16: e1002728. |
| Kubota K., Kamijima Y., Kao Yang Y.H., Kimura S., Lai E.C.C., Man K.C.K., Ryan P., Schuemie M., Stang P., Su C.C., Wong I.C.K., Zhang Y. and Setoguchi S., Penetration of new antidiabetic medications in East Asian countries and the United States: A cross-national comparative study, PLOS ONE. 2018, 13: e0208796. |
| Ma T.T., Wong I.C.K., Man K.C.K., Chen Y., Crake T., Ozkor M.A., Ding L.Q., Wang Z.X., Zhang L. and Wei L., Effect of evidence-based therapy for secondary prevention of cardiovascular disease: Systematic review and meta-analysis, PLOS ONE. 2019, 14: e0210988. |
| McCarthy S., Neubert A., Man K.C.K., Banaschewski T., Buitelaar J., Carucci S., Coghill D., Danckaerts M., Falissard B., Garas P., Häge A., Hollis C., Inglis S., Kovshoff H., Liddle E., Mechler K., Nagy P., Rosenthal E., Schlack R., Sonuga-Barke E., Zuddas A. and Wong I.C.K., Effects of long-term methylphenidate use on growth and blood pressure: results of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS), BMC Psychiatry. 2018, 18. |
| Naser A.Y., Wong I.C.K., Whittlesea C., Beykloo M.Y., Man K.C.K., Lau C.Y., Hyassat D.A.H. and Wei L., Use of multiple antidiabetic medications in patients with diabetes and its association with hypoglycaemic events: a case-crossover study in Jordan, BMJ Open. 2018, 8: e024909. |
| Shi Y.M., Wong C.K.H., Man K.C.K., Chan E.W., Ho C.W., Tse T.Y.E., Wong I.C.K. and Lam C.L.K., Treatment intensification with Dipeptidylpeptidase-4 inhibitor, insulin, or Thiazolidinediones and risks of cardiovascular diseases and all-cause mortality in patients on metformin-sulfonylurea dual therapy, 14th International Symposium on Healthy Aging “Embrace the Golden Years”, Hong Kong, 2019. . |
| Wang Z., Ho P.W.H., Choy M.T.H., Wong I.C.K., Brauer R. and Man K.C.K., Advances in Epidemiological Methods and Utilisation of Large Databases: A Methodological Review of Observational Studies on Central Nervous System Drug Use in Pregnancy and Central Nervous System Outcomes in Children, Drug Safety. 2018. |
| Researcher : Man RYK |
| List of Research Outputs |
| Leung S.W.S., Cai Y., ZHANG Y., Vanhoutte P.M.G.R., Sun X., Feinberg M.W. and Man R.Y.K., Upregulation of miRNA-17-3p reduces inflammatory responses in rats, The 8th Scientific Meeting of Asian Society for Vascular Biology (ASVB), 2 to 4 November 2018, Shanghai, China. 2018. |
| Researcher : Man WCA |
| List of Research Outputs |
| Ellie A., Bloksgaard M., Sun W.Y., Yang K., Man W.C.A., Xu A., Irmukhamedov A., . Riber L., Wang Y., De Mey J. and Pablo G., Local enrichment of fatty acid-binding protein 4 in the pericardial cavity of cardiovascular disease patients, PLOS ONE. 2018, 13: e0206802. |
| Guo Y., Man W.C.A., Luo C., Huang Y., Xu A., Vanhoutte P.M.G.R. and Wang Y., SIRT1 prevents age-induced impairment of vasodilator responses by enhancing the expression and activity of soluble guanylyl cyclase, Cardiovascular Research . 2018. |
| Researcher : Pathadka S |
| List of Research Outputs |
| Chan E.W., Li X., Pathadka S. and Wong I.C.K., Budget impact analysis of introducing Tofacitinib for the treatment of patients with rheumatoid arthritis in Hong Kong, ISPOR 8th Asia-Pacific Conference, Tokyo, Japan, 8-11th September. 2018. |
| Li X., Pathadka S., Man K.K., Wong I.C.K. and Chan E.W.Y., Budget impact of introducing tofacitinib to the public hospital formulary in Hong Kong, 2017-2021., Hong Kong Med. J. . 2019, 25(3): 201-208. |
| Researcher : QIU Y |
| List of Research Outputs |
| QIU Y., TAM B., CHUNG W.Y.W., MASON A.J. and Lam J.K.W., Relationship between the secondary structure of the peptide based siRNA carrier and effective gene silencing effect on lung epithelial cells, Journal of Aerosol Medicine and Pulmonary Drug Delivery. Mary Ann Liebert, 2019, 32: A16-17. |
| Researcher : REN W |
| List of Research Outputs |
| REN W., Cai Y., Zhang Y., Ho Y.W., Lam J.K.W., Vanhoutte P.M.G.R. and Leung S.W.S., MicroRNA-17-3p blunts endothelial responses to inflammatory stimuli, 13th MOVD / 7th EDH 2019, Rotterdam, The Netherlands, May 20-22, 2019. |
| Researcher : Shami JJP |
| List of Research Outputs |
| Li X., Shami J.J.P., Suh I.H. and Chan E.W.Y., Cost-effectiveness of pneumococcal vaccination strategies in older adults of Hong Kong, ISPOR 2019. New Orleans, LA, USA, 18-22nd May . Value in Health, 2019, 22(S2): S200. |
| Researcher : Sing CW |
| List of Research Outputs |
| Cheung C.L., Sing C.W., Wong W., Kiel D., Cheung E., Lam J., Cheung T.T., Chan E.W.Y., Kung A.W.C. and Wong I.C.K., Association of Alendronate and Risk of Cardiovascular Events in Patients with Hip Fracture., Annual Meeting of the American-Society-for-Bone-and-Mineral-Research.. 2018. |
| Sing C.W., Wong Y.S., Kiel D.P., Cheung E.Y., Lam K.Y.J., Cheung T.T., Chan E.W., Kung A.W.C., Wong I.C.K. and Cheung C.L., Association of Alendronate and Risk of Cardiovascular Events in Patients With Hip Fracture, Journal of Bone and Mineral Research. 2018, 33: 1422-1434. |
| Sing C.W., Wong A.Y., Kiel D.P., Cheung E.Y., Lam J.K., Cheung T.T., Chan E.W., Kung A.W.C., Wong I.C.K. and Cheung C.L., Reply to: Association Between Alendronate and All-Cause Mortality and Cardiovascular Mortality Among Hip Fracture: An Alternative Explanation, J Bone Miner Res. 2018, 33(10): 1908-1909. |
| Researcher : Suh IH |
| List of Research Outputs |
| Li X., Shami J.J.P., Suh I.H. and Chan E.W.Y., Cost-effectiveness of pneumococcal vaccination strategies in older adults of Hong Kong, ISPOR 2019. New Orleans, LA, USA, 18-22nd May . Value in Health, 2019, 22(S2): S200. |
| Researcher : Sun WY |
| Project Title: | Mechanisms Of VasoDilatation/Endothelium-Dependent Hyperpolarization symposia; Role of adipocyte-derived lipocalin-2 in dietary obesity-induced hypertension via remodelling of vascular function |
| Investigator(s): | Sun WY |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2019 |
| Completion Date: | 05/2019 |
| List of Research Outputs |
| Ellie A., Bloksgaard M., Sun W.Y., Yang K., Man W.C.A., Xu A., Irmukhamedov A., . Riber L., Wang Y., De Mey J. and Pablo G., Local enrichment of fatty acid-binding protein 4 in the pericardial cavity of cardiovascular disease patients, PLOS ONE. 2018, 13: e0206802. |
| Sun W.Y., Bai B., Luo C., Yang K., LI D., Wu D., Feletou M., Villeneuve N., Zhou Y., Yang J., Xu A., Vanhoutte P.M.G.R. and Wang Y., Lipocalin-2 derived from adipose tissue mediates aldosterone-induced renal injury, Journal of Clinical Investigation Insight. 2018, 3(17): e120196. |
| Researcher : Tam AW |
| List of Research Outputs |
| Li X., BLAIS J.E., Wong I.C.K., Tam A.W., Cowling B.J., Hung F.N.I. and Chan E.W.Y., Population-based estimates of the burden of pneumonia hospitalizations in Hong Kong, 2011–2015. , Eur J Clin Microbiol Infect Dis. 2019, 38(3): 553-561. |
| Researcher : Tang EHC |
| Project Title: | Telomere-independent Rap1 contributes to inflammation during atherosclerosis |
| Investigator(s): | Tang EHC, Man RYK, Leung SWS |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2013 |
| Project Title: | Regulation of triglyceride metabolism by prostaglandin E receptor subtype 4 |
| Investigator(s): | Tang EHC |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2013 |
| Project Title: | Rap1 aggravates the development of angiotensin II-induced aortic abdominal aneurysm in apolipoprotein E-deficient mice. |
| Investigator(s): | Tang EHC |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2014 |
| Researcher : Tang HC |
| Project Title: | Telomere-independent Rap1 contributes to inflammation during atherosclerosis |
| Investigator(s): | Tang EHC, Man RYK, Leung SWS |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | National Natural Science Foundation of China (NSFC) - General Program |
| Start Date: | 01/2013 |
| Project Title: | Regulation of triglyceride metabolism by prostaglandin E receptor subtype 4 |
| Investigator(s): | Tang EHC |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2013 |
| Project Title: | Rap1 aggravates the development of angiotensin II-induced aortic abdominal aneurysm in apolipoprotein E-deficient mice. |
| Investigator(s): | Tang EHC |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2014 |
| Researcher : Tom WM |
| Project Title: | VII World Conference on Clinical Pharmacology and Therapeutics 4th Congress of the European Association for Clinical Pharmacology and Therapeutics Antidotal Mechanisms of Hydroxyacetone and Dihydroxyacetone in the Treatment of Acute Acetonitrile Poisoning |
| Investigator(s): | Tom WM |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 07/2000 |
| Researcher : Vanhoutte P.M.G. |
| Project Title: | Annual Summer School in Danish Cardiovascular Research Academy Veins in health and disease |
| Investigator(s): | Vanhoutte PMGR |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2007 |
| Project Title: | Visiting Research Professors Scheme 2009-10 |
| Investigator(s): | Vanhoutte PMGR |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Visiting Research Professors Scheme |
| Start Date: | 09/2009 |
| Project Title: | A Study of the Relative Significance of Nitric Oxide Synthase vs NADPH oxidase in Endothelial Senescence |
| Investigator(s): | Vanhoutte PMGR, Wang Y |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 10/2009 |
| Project Title: | Human Prostacyclin Receptors and Endothelial Dysfunction |
| Investigator(s): | Vanhoutte PMGR, Xu A, Wang Y, Leung SWS |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2016 |
| Completion Date: | 10/2019 |
| List of Research Outputs |
| Researcher : Vanhoutte PMGR |
| Project Title: | Annual Summer School in Danish Cardiovascular Research Academy Veins in health and disease |
| Investigator(s): | Vanhoutte PMGR |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2007 |
| Project Title: | Visiting Research Professors Scheme 2009-10 |
| Investigator(s): | Vanhoutte PMGR |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Visiting Research Professors Scheme |
| Start Date: | 09/2009 |
| Project Title: | A Study of the Relative Significance of Nitric Oxide Synthase vs NADPH oxidase in Endothelial Senescence |
| Investigator(s): | Vanhoutte PMGR, Wang Y |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 10/2009 |
| Project Title: | Human Prostacyclin Receptors and Endothelial Dysfunction |
| Investigator(s): | Vanhoutte PMGR, Xu A, Wang Y, Leung SWS |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2016 |
| Completion Date: | 10/2019 |
| List of Research Outputs |
| Assersen K.B., Jensen P.S., Briones A.M., Rasmussen L.M., Marcussen N., Toft A., Vanhoutte P.M.G.R., Jensen B.L. and Hansen P.B.L., Periarterial fat from two human vascular beds is not a source of aldosterone to promote vasoconstriction, American Journal of Physiology-Renal Physiology. 2018, 315: F1670-F1682. |
| Baretella O.M., Xu A. and Vanhoutte P.M.G.R., No Protective Effect of Constitutive Activation of AMPK in Endothelial Cells on Vascular Function in Aged Obese Mice but Augmented α1-Adrenergic Contractions in Renal Arteries Reversible by Weight Loss, Journal of Vascular Research. 2018, 189-202. |
| CHEN H., Vanhoutte P.M.G.R. and Leung S.W.S., AMPK-activation reduces EDH-type relaxations in rat small arteries , 22nd Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine (ICSM): From Cardiovascular Science to Cardiovascular Medicine, in Conjunction with 7th Asian Preventive Cardiology & Cardiac Rehabilitation Conference, 10 Nov 2018, Hong Kong. 2018, 26: 101. |
| CHEN H., Leung S.W.S. and Vanhoutte P.M.G.R., Activation of AMPK inhibits EDH-like relaxations in rat superior mesenteric arteries, Chinese Society For Vascular Medicine, Asian Society For Vascular Biology, Shanghai, November 4, 2018. |
| CHEN H., Vanhoutte P.M.G.R. and Leung S.W.S., Activation of AMPK inhibits EDH-like relaxations in rat superior mesenteric arteries, The 8th Scientific Meeting of Asian Society for Vascular Biology (ASVB), 2 to 4 November 2018, Shanghai, China. 2018. |
| CHEN H., Vanhoutte P.M.G.R. and Leung S.W.S., Biased modulation of EDH-type relaxations by AMPK in hypertension, The 13th International Symposium on Mechanisms of Vasodilatation and 7th International Symposium on Endothelium-Dependent Hyperpolarization (MOVD/EDH 2019), 20-22 May 2019, Rotterdam, The Netherlands. 2019. |
| CHENG Y., Vanhoutte P.M.G.R. and Leung S.W.S., Apolipoprotein E deletion protects prostacyclin receptor activation in mouse aorta, Chinese Society For Vascular Medicine, Asian Society For Vascular Biology, Shanghai, November 4, 2019. 2018. |
| CHENG Y., Vanhoutte P.M.G.R. and Leung S.W.S., Apolipoprotein E deletion protects prostacyclin receptor activation in mouse aorta, The 8th Scientific Meeting of Asian Society for Vascular Biology (ASVB), 2 to 4 November 2018, Shanghai, China. 2018. |
| CHENG Y., Vanhoutte P.M.G.R. and Leung S.W.S., Apolipoprotein E deletion protects prostacyclin receptor agonist-induced relaxations in mouse aorta, 18th World Congress of Basic And Clinical Pharmacology, 1-6 July 2018, Kyoto, Japan. 2018. |
| CHENG Y., Vanhoutte P.M.G.R. and Leung S.W.S., Apolipoprotein E favours the blunting by high-fat diet of prostacyclin receptor activation in the mouse aorta, British Journal of Pharmacology. WILEY, 2018, 175: 3453-3469. |
| CHENG Y., Dusting G.J., Vanhoutte P.M.G.R. and Leung S.W.S., Apolipoprotein E-deletion potentiates endothelium-dependent relaxations to prostacyclin receptor activation in the mouse aorta, 13th International Symposium on Mechanisms of Vasodilatation and 7th International Symposium on Endothelium-Dependent Hyperpolarization (MOVD/EDH 2019), 20-22 May 2019, Rotterdam, The Netherlands. 2019. |
| CHENG Y., Dusting G., Vanhoutte P.M.G.R. and Leung S.W.S., Apolipoprotein E-deletion potentiates endothelium-dependent relaxations to prostacyclin receptor activation in the mouse aorta, 13th MOVD / 7th EDH 2019, Rotterdam, The Netherlands May 20-22, 2019. |
| DETREMMERIE C.M.S., Leung S.W.S. and Vanhoutte P.M.G.R., Activation of NQO-1 mediates the augmented contractions of isolated arteries due to biased activity of soluble guanylyl cyclase in their smooth muscle, Naunyn-Schmiedeberg's Archives of Pharmacology. 2018, 391: 1221-1235. |
| Guo Y., Man W.C.A., Luo C., Huang Y., Xu A., Vanhoutte P.M.G.R. and Wang Y., SIRT1 prevents age-induced impairment of vasodilator responses by enhancing the expression and activity of soluble guanylyl cyclase, Cardiovascular Research . 2018. |
| KONJA D., ZHANG P., Luo C., Xu A., Vanhoutte P.M.G.R. and Wang Y., Overexpression of SIRT1 in perivascular adipose tissue enhances vasodilatation and prevents adverse arterial remodeling by modulating the crosstalks between mitochondria and endoplasmic reticulum, 13th MOVD /7th EDH 2019, Rotterdam, The Netherlands, May 20-22, 2019. |
| Lee Y.K.M., Ge M., Fung M.L., Vanhoutte P.M.G.R., Mak J.C.W. and Ip M.S.M., Low but not high frequency of intermittent hypoxia suppresses endothelium-dependent, oxidative stress-mediated contractions in carotid arteries of obese mice, Journal of Applied Physiology. 2018, 125: 1384-1395. |
| Leung S.W.S., Detremmerie C.M.S. and Vanhoutte P.M.G.R., Biased activation of soluble guanylyl cyclase by quinones causes contractions of isolated arteries: Role of NADPH:quinone oxidoreductase-1, 18th World Congress of Basic And Clinical Pharmacology, 1-6 July 2018, Kyoto, Japan. 2018. |
| Leung S.W.S., Cai Y., ZHANG Y., Vanhoutte P.M.G.R., Sun X., Feinberg M.W. and Man R.Y.K., Upregulation of miRNA-17-3p reduces inflammatory responses in rats, The 8th Scientific Meeting of Asian Society for Vascular Biology (ASVB), 2 to 4 November 2018, Shanghai, China. 2018. |
| REN W., Cai Y., Zhang Y., Ho Y.W., Lam J.K.W., Vanhoutte P.M.G.R. and Leung S.W.S., MicroRNA-17-3p blunts endothelial responses to inflammatory stimuli, 13th MOVD / 7th EDH 2019, Rotterdam, The Netherlands, May 20-22, 2019. |
| Sun W.Y., Bai B., Luo C., Yang K., LI D., Wu D., Feletou M., Villeneuve N., Zhou Y., Yang J., Xu A., Vanhoutte P.M.G.R. and Wang Y., Lipocalin-2 derived from adipose tissue mediates aldosterone-induced renal injury, Journal of Clinical Investigation Insight. 2018, 3(17): e120196. |
| Researcher : WENG J |
| List of Research Outputs |
| Chow S.F., WENG J., XUAN B. and WAN K.Y., How can the challenges faced by nanoparticle-based pulmonary drug formulations be overcome, Therapeutic Delivery. 2019. |
| WENG J., Wong S.N., Xu X., XUAN B., Wang C., Chen R., Sun C.C., Lakerveld R., Kwok P.C.L. and Chow S.F., Cocrystal Engineering of Itraconazole with Suberic acid via Rotary Evaporation and Spray Drying, Crystal Growth & Design. 2019. |
| WENG J., Wong S.N., Wan K.Y., Chow A.H.L. and Chow S.F., Comparative Evaluation of Four Structurally-Related Profens for Nanoparticle Formulation, AAPS PharmSci 360. 2018. |
| Researcher : WU X |
| List of Research Outputs |
| CHEONG L.Y., Wang B., Shu L., WU X., Hoo R.L.C. and Xu A., Absence of inguinal lymph nodes impairs the browning of subcutaneous white adipose tissue in mice , 2018 FASEB Science Research Conferences - Immunological Aspects of Metabolic Syndrome . 2018. |
| Shu L., WU X., CHEONG L.Y., Zhou Z., Hoo R.L.C., Lam K.S.L. and Xu A., FABP4 mediates autoimmune destruction of beta cells by enhancing the crosstalk between innate and adaptive immunity/ Oral presentation, Asia Islet Biology and Incretin Symposium (AIBIS 2018). 2018. |
| Researcher : Wang W |
| Project Title: | Ultrasound-responsive polymeric nanoparticles for tumour targeting |
| Investigator(s): | Wang W |
| Department: | Dr. Li Dak-Sum Research Centre |
| Source(s) of Funding: | Seed Fund for Basic Research for New Staff |
| Start Date: | 06/2017 |
| Project Title: | Photo-triggered high-efficiency drug release based on a photosensitizable and photocleavable group |
| Investigator(s): | Wang W, Lyu W |
| Department: | Dr. Li Dak-Sum Research Centre |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 05/2018 |
| Project Title: | Construction of photoresponsive small-molecule nanoparticles as drug delivery carriers |
| Investigator(s): | Wang W, Wang Y |
| Department: | Dr. Li Dak-Sum Research Centre |
| Source(s) of Funding: | Seed Fund for Basic Research for Resubmission of GRF/ECS Proposals |
| Start Date: | 07/2018 |
| Completion Date: | 11/2018 |
| Project Title: | European Advanced Materials Congress 2018; Stimuli-responsive nanoparticles self-assembled from triskelion molecules for drug delivery |
| Investigator(s): | Wang W |
| Department: | Dr. Li Dak-Sum Research Centre |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 08/2018 |
| Completion Date: | 08/2018 |
| List of Research Outputs |
| LI Y. and Wang W., Photo-controlled dendrimers for cancer therapy, ICMAT 2019, June 23-28, 2019 Singapore. 2019. |
| ZHANG Y. and Wang W., Polymer prodrug-based nanoreactors activated by light for combined oxidation and chmotherapy, ICMAT 2019, June 23-28, 2019 Singapore. 2019. |
| Researcher : Wang Y |
| Project Title: | Outstanding Young Researcher Award 2009-10 |
| Investigator(s): | Wang Y |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Outstanding Young Researcher Award |
| Start Date: | 12/2010 |
| Project Title: | Molecular dissection of the pathogenic adipose-vascular signaling axis associated with obesity - focusing on polyamination and deamidation of lipocalin-2 |
| Investigator(s): | Wang Y, Yuen KY |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Role of Endothelial SIRT1 in the Prevention of Vascular Ageing - focusing on arterial remodeling and circadian rhythmicity |
| Investigator(s): | Wang Y, Vanhoutte PMGR |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 09/2016 |
| Project Title: | Timely resetting mitochondrial function by SIRT1 in adipose tissue determines the pace of metabolic ageing in mice |
| Investigator(s): | Wang Y |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2017 |
| Project Title: | Selective overexpression of SIRT1 in adipose tissue protects adiponectin deficiency induced liver injury |
| Investigator(s): | Wang Y, Xu C |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2017 |
| Project Title: | Role of lipocalin-2 in adipose tissue expansion, phenotypic switching and fibrotic damages during the development of cardiometabolic syndrome |
| Investigator(s): | Wang Y, Sun WY |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2017 |
| Completion Date: | 05/2019 |
| Project Title: | Lipocalin-2: a key mediator of tissue fibrosis in obesity-associated cardiometabolic renal syndrome |
| Investigator(s): | Wang Y, Vanhoutte PMGR |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2018 |
| Project Title: | Endothelial SIRT1 - a key circadian regulator controlling the 24-hour rhythmicity in blood pressure and energy metabolism |
| Investigator(s): | Wang Y, Vanhoutte PMGR |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2019 |
| Project Title: | MOVD/EDH 2019; Lipocalin-2, a versatile drug target for cardiovascular diseases (Final Report: Lipocalin-2, a versatile drug target for cardiometabolic and renal diseases) |
| Investigator(s): | Wang Y |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2019 |
| Completion Date: | 05/2019 |
| Project Title: | Metabolic characterization of adipose tissue-specific Triadin transgenic and knockout mice |
| Investigator(s): | Wang Y |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2019 |
| List of Research Outputs |
| Ellie A., Bloksgaard M., Sun W.Y., Yang K., Man W.C.A., Xu A., Irmukhamedov A., . Riber L., Wang Y., De Mey J. and Pablo G., Local enrichment of fatty acid-binding protein 4 in the pericardial cavity of cardiovascular disease patients, PLOS ONE. 2018, 13: e0206802. |
| Guo Y., Man W.C.A., Luo C., Huang Y., Xu A., Vanhoutte P.M.G.R. and Wang Y., SIRT1 prevents age-induced impairment of vasodilator responses by enhancing the expression and activity of soluble guanylyl cyclase, Cardiovascular Research . 2018. |
| KONJA D., ZHANG P., Luo C., Xu A., Vanhoutte P.M.G.R. and Wang Y., Overexpression of SIRT1 in perivascular adipose tissue enhances vasodilatation and prevents adverse arterial remodeling by modulating the crosstalks between mitochondria and endoplasmic reticulum, 13th MOVD /7th EDH 2019, Rotterdam, The Netherlands, May 20-22, 2019. |
| Pan Y., Hui X., Hoo R.L.C., Ye D., Chan C.Y.C., Feng T., Wang Y., Lam K.S.L. and Xu A., Adipocyte-secreted Exosomal Microrna-34a Inhibits M2 Macrophage Polarization To Promote Obesity-induced Adipose Inflammation, Journal of Clinical Investigation. 2019, 129: 834-849. |
| Sun W.Y., Bai B., Luo C., Yang K., LI D., Wu D., Feletou M., Villeneuve N., Zhou Y., Yang J., Xu A., Vanhoutte P.M.G.R. and Wang Y., Lipocalin-2 derived from adipose tissue mediates aldosterone-induced renal injury, Journal of Clinical Investigation Insight. 2018, 3(17): e120196. |
| Researcher : Wang Y. |
| Project Title: | Outstanding Young Researcher Award 2009-10 |
| Investigator(s): | Wang Y |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Outstanding Young Researcher Award |
| Start Date: | 12/2010 |
| Project Title: | Molecular dissection of the pathogenic adipose-vascular signaling axis associated with obesity - focusing on polyamination and deamidation of lipocalin-2 |
| Investigator(s): | Wang Y, Yuen KY |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2015 |
| Project Title: | Role of Endothelial SIRT1 in the Prevention of Vascular Ageing - focusing on arterial remodeling and circadian rhythmicity |
| Investigator(s): | Wang Y, Vanhoutte PMGR |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 09/2016 |
| Project Title: | Timely resetting mitochondrial function by SIRT1 in adipose tissue determines the pace of metabolic ageing in mice |
| Investigator(s): | Wang Y |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2017 |
| Project Title: | Selective overexpression of SIRT1 in adipose tissue protects adiponectin deficiency induced liver injury |
| Investigator(s): | Wang Y, Xu C |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2017 |
| Project Title: | Role of lipocalin-2 in adipose tissue expansion, phenotypic switching and fibrotic damages during the development of cardiometabolic syndrome |
| Investigator(s): | Wang Y, Sun WY |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2017 |
| Completion Date: | 05/2019 |
| Project Title: | Lipocalin-2: a key mediator of tissue fibrosis in obesity-associated cardiometabolic renal syndrome |
| Investigator(s): | Wang Y, Vanhoutte PMGR |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2018 |
| Project Title: | Endothelial SIRT1 - a key circadian regulator controlling the 24-hour rhythmicity in blood pressure and energy metabolism |
| Investigator(s): | Wang Y, Vanhoutte PMGR |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2019 |
| Project Title: | MOVD/EDH 2019; Lipocalin-2, a versatile drug target for cardiovascular diseases (Final Report: Lipocalin-2, a versatile drug target for cardiometabolic and renal diseases) |
| Investigator(s): | Wang Y |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2019 |
| Completion Date: | 05/2019 |
| Project Title: | Metabolic characterization of adipose tissue-specific Triadin transgenic and knockout mice |
| Investigator(s): | Wang Y |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2019 |
| List of Research Outputs |
| Researcher : Wong ICK |
| Project Title: | Feasibility study of the effects of clonidine and melatonin treatment on sleep architecture of children with ADHD. |
| Investigator(s): | Wong ICK |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Translational and Applied Research |
| Start Date: | 04/2015 |
| Project Title: | 18th Annual Meeting of the International Society of Pharmacovigilance; A Methodological Review Of Observational Studies On Central Nervous System Drugs Use In Pregnancy And Outcomes In Children/Scientific Chair Conference opening speech |
| Investigator(s): | Wong ICK |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2018 |
| Completion Date: | 11/2018 |
| Project Title: | Oral Anticoagulant Therapy and the Risk of Dementia in Patients with Atrial Fibrillation: A Propensity-score Weighted Cohort Study |
| Investigator(s): | Wong ICK |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2019 |
| List of Research Outputs |
| Alfageh B.H., Wang Z., Mongkhon P., Besag F.M.C., Alhawassi T.M., Brauer R. and Wong I.C.K., Safety and Tolerability of Antipsychotic Medication in Individuals with Autism Spectrum Disorder: A Systematic Review and Meta-Analysis, Pediatric Drugs. 2019, 21: 153-167. |
| Almandil N.B., Lodhi R.J., Ren H., Besag F.M.C., Rossolatos D., Ohlsen R., Slomp C., Lapetina D.L., Plazzotta G., Murray M.L., Al-Sulaiman A.A., Gringras P., Wong I.C.K. and Aitchison K.J., Associations between the LEP -2548G/A Promoter and Baseline Weight and between LEPR Gln223Arg and Lys656Asn Variants and Change in BMI z Scores in Arab Children and Adolescents Treated with Risperidone, Molecular Neuropsychiatry. 2018, 4: 111-117. |
| BLAIS J.E., Chan E.W.Y., Law W.Y., Mok M.T., Huang D., Wong I.C.K. and Siu D.C.W., Trends in statin prescription prevalence, initiation, and dosing: Hong Kong, 2004–2015, Atherosclerosis. 2018, 280: 174-182. |
| Brauer R., Lau C.Y., Hayes J.F., Man K.C.K., Osborn D.P.J., Howard R., Kim J. and Wong I.C.K., Trazodone use and risk of dementia: A population-based cohort study, PLOS Medicine. 2019, 16: e1002728. |
| Chan E.W., Li X., Pathadka S. and Wong I.C.K., Budget impact analysis of introducing Tofacitinib for the treatment of patients with rheumatoid arthritis in Hong Kong, ISPOR 8th Asia-Pacific Conference, Tokyo, Japan, 8-11th September. 2018. |
| Cheung C.L., Sing C.W., Wong W., Kiel D., Cheung E., Lam J., Cheung T.T., Chan E.W.Y., Kung A.W.C. and Wong I.C.K., Association of Alendronate and Risk of Cardiovascular Events in Patients with Hip Fracture., Annual Meeting of the American-Society-for-Bone-and-Mineral-Research.. 2018. |
| Cheung K.S.M., Chan E.W.Y., Wong A.S.Y., Chen L., Seto W.K.W., Wong I.C.K. and Leung W.K., Statin use and gastric cancer risk in Helicobacter pylori-eradicated patients: a territory-wide study with propensity score matching, Medical Research Conference, Hong Kong. 2019. |
| Cheung K.S.M., Chen L., Chan E.W., Seto W.K.W., Wong I.C.K. and Leung W.K., Statins reduce the progression of non-advanced adenomas to colorectal cancer: a postcolonoscopy study in 187 897 patients, Gut. 2019, gutjnl-2018-317714. |
| Cheung K.S.M., Chan E.W.Y., Chen L., Seto W.K.W., Wong I.C.K. and Leung W.K., Use of non-aspirin non-steroidal anti-inflammatory drugs and risk of post-colonoscopy colorectal cancer: a territory-wide study with propensity score analysis, Digestive Disease Week . 2019. |
| Daley D., Van D.O.S., Ferrin M., Cortese S., Danckaerts M., Doepfner M., Van D.H.B.J., Coghill D., Thompson M., Asherson P., Banaschewski T., Brandeis D., Buitelaar J., Dittmann R.W., Hollis C., Holtmann M., Konofal E., Lecendreux M., Rothenberger A., Santosh P., Simonoff E., Soutullo C., Steinhausen H.C., Stringaris A., Taylor E., Wong I.C.K., Zuddas A. and Sonuga-Barke E.J., Practitioner Review: Current best practice in the use of parent training and other behavioural interventions in the treatment of children and adolescents with attention deficit hyperactivity disorder, Journal of Child Psychology and Psychiatry. 2018, 59: 932-947. |
| Fanning L., Ryan-Atwood T.E., Bell J.S., Meretoja A., McNamara K.P., Darzins P., Wong I.C.K. and Ilomaki J., Prevalence, Safety, and Effectiveness of Oral Anticoagulant Use in People with and without Dementia or Cognitive Impairment: A Systematic Review and Meta-Analysis, Journal of Alzheimer's Disease. 2018, 65: 489-517. |
| GUO C., Cheung K.S.M., Zhang F., Chan E.W.Y., Chen L., Wong I.C.K. and Leung W.K., Incidences, temporal trends and risks of hospitalisation for gastrointestinal bleeding in new or chronic low-dose aspirin users after treatment for Helicobacter pylori : a territory-wide cohort study , Gut. 2019, gutjnl-2019-318352. |
| GUO C., Chen L., Chan E.W.Y., Cheung K.S.M., Isshiki T., Wong I.C.K. and Leung W.K., Systematic review with meta- analysis: the risk of gastrointestinal bleeding in patients taking third-generation P2Y12 inhibitors compared with clopidogrel, Alimentary Pharmacology & Therapeutics. 2019. |
| Harrop E., Jamieson L., Choy T.H., Ho W.H.P. and Wong I.C.K., Barriers to the use of buccal and intranasal fentanyl for breakthrough pain in paediatric palliative care: an exploratory survey, BMJ Supportive & Palliative Care. 2018, 8: 355-356. |
| Hayes J.F., Lundin A., Wicks S., Lewis G., Wong I.C.K., Osborn D.P.J. and Dalman C., Association of Hydroxylmethyl Glutaryl Coenzyme A Reductase Inhibitors, L-Type Calcium Channel Antagonists, and Biguanides With Rates of Psychiatric Hospitalization and Self-Harm in Individuals With Serious Mental Illness, JAMA Psychiatry. 2019, 76: 382. |
| Hsia Y., Sharland M., Jackson C., Wong I.C.K., Magrini N. and Bielicki J.A., Consumption of oral antibiotic formulations for young children according to the WHO Access, Watch, Reserve (AWaRe) antibiotic groups: an analysis of sales data from 70 middle-income and high-income countries, The Lancet Infectious Diseases. 2019, 19: 67-75. |
| Jackson C., Hsia Y., Bielicki J.A., Ellis S., Stephens P., Wong I.C.K. and Sharland M., Estimating global trends in total and childhood antibiotic consumption, 2011-2015, BMJ Global Health. 2019, 4: e001241. |
| Kuan V., Denaxas S., Gonzalez-Izquierdo A., Direk K., Bhatti O., Husain S., Sutaria S., Hingorani M., Nitsch D., Parisinos C.A., Lumbers R.T., Mathur R., Sofat R., Casas J.P., Wong I.C.K., Hemingway H. and Hingorani A.D., A chronological map of 308 physical and mental health conditions from 4 million individuals in the English National Health Service, The Lancet Digital Health. 2019, 1: e63-e77. |
| Kubota K., Kamijima Y., Kao Yang Y.H., Kimura S., Lai E.C.C., Man K.C.K., Ryan P., Schuemie M., Stang P., Su C.C., Wong I.C.K., Zhang Y. and Setoguchi S., Penetration of new antidiabetic medications in East Asian countries and the United States: A cross-national comparative study, PLOS ONE. 2018, 13: e0208796. |
| Lai E.C.C., Ryan P., Zhang Y., Schuemie M.J., Hardy C., Kamijima Y., Kimura S., Kubota K., Man K.C.K., Cho S.Y., Park R.W., Stang P., Su C.C., Wong I.C.K., Yang Kao Y.H. and Setoguchi S., Applying a common data model to Asian databases for multinational pharmacoepidemiologic studies: opportunities and challenges, Clinical Epidemiology. 2018, Volume 10: 875-885. |
| Lai E.C.C., Shin J.Y., Kubota K., Man K.C.K., Park B.J., Pratt N.L., Roughead E.E., Wong I.C.K., Kao Yang Y.H. and Setoguchi S., Comparative safety of NSAIDs for gastrointestinal events in Asia-Pacific populations: A multi-database, international cohort study, Pharmacoepidemiology and Drug Safety. 2018. |
| Lau W.C.Y., Bielicki J., Tersigni C., Saxena S., Wong I.C.K., Sharland M. and Hsia Y., All‐cause pneumonia in children after the introduction of pneumococcal vaccines in the United Kingdom: A population‐based study, Pharmacoepidemiology and Drug Safety. 2019. |
| Law W.Y., Lau W.C.Y., Wong I.C.K. and Chan E.W.Y., Reply: Sex-Based Differences in Outcomes of Oral Anticoagulation: Does Antiplatelet Therapy Matter?, Journal of the American College of Cardiology. 2018, 72: 2547-2548. |
| Law W.Y., Lau C.Y., Wong I.C.K., Lip G.Y.H., Mok M.T., Siu D.C.W. and Chan E.W., Sex-based differences in outcomes of oral anticoagulation in patients with atrial fibrillation, Journal of the American College of Cardiology. 2018, 72: 271-282. |
| Li X., Pathadka S., Man K.K., Wong I.C.K. and Chan E.W.Y., Budget impact of introducing tofacitinib to the public hospital formulary in Hong Kong, 2017-2021., Hong Kong Med. J. . 2019, 25(3): 201-208. |
| Li X., Wong I.C.K., McGhee S., Kwan M.Y.W., Wong C.K.H., Ip D.K.M., Chau J. and Chan E.W.Y., Mothers' preference and willingness to pay for human papillomavirus vaccination for their daughters: a discrete choice experiment, Hong Kong Med J. Hong Kong, 2018, 24(Suppl 6): S34-6. |
| Li X., BLAIS J.E., Wong I.C.K., Tam A.W., Cowling B.J., Hung F.N.I. and Chan E.W.Y., Population-based estimates of the burden of pneumonia hospitalizations in Hong Kong, 2011–2015. , Eur J Clin Microbiol Infect Dis. 2019, 38(3): 553-561. |
| Ma T.T., Wong I.C.K., Man K.C.K., Chen Y., Crake T., Ozkor M.A., Ding L.Q., Wang Z.X., Zhang L. and Wei L., Effect of evidence-based therapy for secondary prevention of cardiovascular disease: Systematic review and meta-analysis, PLOS ONE. 2019, 14: e0210988. |
| Manias E., Cranswick N., Newall F., Rosenfeld E., Weiner C., Williams A., Wong I.C.K., Borrott N., Lai J. and Kinney S., Medication error trends and effects of person-related, environment-related and communication-related factors on medication errors in a paediatric hospital, Journal of Paediatrics and Child Health. 2019, 55: 320-326. |
| McCarthy S., Neubert A., Man K.C.K., Banaschewski T., Buitelaar J., Carucci S., Coghill D., Danckaerts M., Falissard B., Garas P., Häge A., Hollis C., Inglis S., Kovshoff H., Liddle E., Mechler K., Nagy P., Rosenthal E., Schlack R., Sonuga-Barke E., Zuddas A. and Wong I.C.K., Effects of long-term methylphenidate use on growth and blood pressure: results of the German Health Interview and Examination Survey for Children and Adolescents (KiGGS), BMC Psychiatry. 2018, 18. |
| McMahon K., Craig M., Beykloo M.Y., Wong I.C.K., Nicholls D., Simic M. and Brauer R., Combining family-based treatment and enhanced cognitive behavioural therapy for eating disorders (CBT-ED) to improve outcomes for young people experiencing eating disorders, EUROPEAN EATING DISORDERS REVIEW. 2018, 26(4): E11-E12. |
| Mongkhon P., Naser A.Y., Naser L., Tse G., Lau W.C.Y., Wong I.C.K. and Kongkaew C., Oral anticoagulants and risk of dementia: A systematic review and meta-analysis of observational studies and randomized controlled trials, Neuroscience & Biobehavioral Reviews. 2019, 96: 1-9. |
| Naser A.Y., Wong I.C.K., Whittlesea C., Beykloo M.Y., Man K.C.K., Lau C.Y., Hyassat D.A.H. and Wei L., Use of multiple antidiabetic medications in patients with diabetes and its association with hypoglycaemic events: a case-crossover study in Jordan, BMJ Open. 2018, 8: e024909. |
| Payne H., Jamieson L., Prentice M., O'Connor A., Wong I.C.K. and Chambers P., Preferences for Toxicity Monitoring of Patients on Abiraterone Acetate Plus Prednisone, Clinical Oncology. 2018, 30: 674-675. |
| Prentice M., Man K., Jani Y., Payne H.A. and Wong I.C.K., Computer modelling in prostate anticancer therapy (COMPACT)., Journal of Clinical Oncology. 2019, 37: e16528-e16528. |
| Raman S.R., Man K.C.K., Bahmanyar S., Berard A., Bilder S., Boukhris T., Bushnell G., Crystal S., Furu K., Kao Yang Y.H., Karlstad Ø., Kieler H., Kubota K., Lai E.C.C., Martikainen J.E., Maura G., Moore N., Montero D., Nakamura H., Neumann A., Pate V., Pottegård A., Pratt N.L., Roughead E.E., Macias Saint-Gerons D., Stürmer T., Su C.C., Zoega H., Sturkenbroom M.C.J.M., Chan E.W., Coghill D., Ip P. and Wong I.C.K., Trends in attention-deficit hyperactivity disorder medication use: a retrospective observational study using population-based databases, The Lancet Psychiatry. 2018. |
| Schuemie M.J., Ryan P.B., Man K.K.C., Wong I.C.K., Suchard M.A. and Hripcsak G., A plea to stop using the case-control design in retrospective database studies, Statistics in Medicine. 2019. |
| Sharland E., Long P., Sharland M., Bielicki J., Saxena S., Wong I.C.K. and Barker C., Early origins of oral penicillin dosing for children, Archives of Disease in Childhood. 2019, archdischild-2018-316531. |
| Shi Y.M., Wong C.K.H., Man K.C.K., Chan E.W., Ho C.W., Tse T.Y.E., Wong I.C.K. and Lam C.L.K., Treatment intensification with Dipeptidylpeptidase-4 inhibitor, insulin, or Thiazolidinediones and risks of cardiovascular diseases and all-cause mortality in patients on metformin-sulfonylurea dual therapy, 14th International Symposium on Healthy Aging “Embrace the Golden Years”, Hong Kong, 2019. . |
| Sing C.W., Wong Y.S., Kiel D.P., Cheung E.Y., Lam K.Y.J., Cheung T.T., Chan E.W., Kung A.W.C., Wong I.C.K. and Cheung C.L., Association of Alendronate and Risk of Cardiovascular Events in Patients With Hip Fracture, Journal of Bone and Mineral Research. 2018, 33: 1422-1434. |
| Sing C.W., Wong A.Y., Kiel D.P., Cheung E.Y., Lam J.K., Cheung T.T., Chan E.W., Kung A.W.C., Wong I.C.K. and Cheung C.L., Reply to: Association Between Alendronate and All-Cause Mortality and Cardiovascular Mortality Among Hip Fracture: An Alternative Explanation, J Bone Miner Res. 2018, 33(10): 1908-1909. |
| Sou Da Rosa Duque J., Cheuk K.L.D., Chong C.Y., Ip P., Wong W.H.S., Lee P.P.W., Wong I.C.K., Chan G.C.F., Lau Y.L. and Ho M.H.K., Older age and male gender as risk factors for IgE-mediated drug allergies in Chinese children, 10th Hong Kong Allergy Convention 2018. |
| Tang Y.M.J., Luo H., Wong G.H.Y., Lau M.Y., Joe G.M., Tse M.A., Ip P., Wong I.C.K. and Lum T.Y.S., Bone mineral density from early to middle adulthood in persons with Down syndrome, Journal of Intellectual Disability Research. 2019. |
| Tso W.Y.W., Chan M.C.M., Ho F.K., Rao N., Li A.M., Chan K.L., Tiwari A.F.Y., Wong I.C.K., Wing Y.K., Van Voorhees B., Li S.L., Goh W.H.S. and Ip P., Early sleep deprivation and attention-deficit/hyperactivity disorder, Pediatric Research. 2019, 85: 449-455. |
| Wang Z., Ho P.W.H., Choy M.T.H., Wong I.C.K., Brauer R. and Man K.C.K., Advances in Epidemiological Methods and Utilisation of Large Databases: A Methodological Review of Observational Studies on Central Nervous System Drug Use in Pregnancy and Central Nervous System Outcomes in Children, Drug Safety. 2018. |
| Wong I.C.K., ADHD medication and health related outcomes in the Hong Kong medical record data, 7th World Congress on ADHD. World Federation of ADHD. 25 - 28 April 2019, Lisbon, Portugal. 2019. |
| Wong I.C.K., ADHD medication and health related outcomes in the Hong Kong medical record data, The 7th World Congress on ADHD from 25 - 28 April 2019 in Lisbon, Portugal.. 2019. |
| Wong I.C.K., Application of phamacoepidemiology in ADHD research, Division of Pharmacy and Optometry, School of Health Sciences, University of Manchester. 4th June 2019. Manchester UK. 2019. |
| Wong I.C.K., Banaschewski T., Buitelaar J., Cortese S., Döpfner M., Simonoff E. and Coghil D., Emerging challenges in pharmacotherapy research on attention-deficit hyperactivity disorder—outcome measures beyond symptom control and clinical trials, The Lancet Psychiatry. 2019, 6: 528-537. |
| Wong I.C.K., Experience of using Real World Evidence (RWE) in Hong Kong and other countries - personal experience and view, University of Hong Kong and Macau University Joint Seminar. 22 June 2019, Macau. 2019. |
| Wong I.C.K., Globalization of pharmacovigilance Personal perspective and the future, Research Centre of Safety and Quality in Healthcare Conference. Naresuan University. Narai Hotel.. 15th February 2019. Bangkok. Thailand. 2019. |
| Wong I.C.K., Long-term treatment outcomes – what have we learnt from Hong Kong pharmacoepidemiological studies, The 5th Eunethydis International Conference. European Network of Hyperkinetic Disorder. Edinburgh, Scotland 23rd September to 26th September 2018.. 2018. |
| Wong I.C.K., Prenatal antidepressants use and risks of ADHD in offspring., The 7th World Congress on ADHD from 25 - 28 April 2019 in Lisbon, Portugal.. 2019. |
| Wong I.C.K., Prenatal antidepressants use and risks of ADHD in offspring, 7th World Congress on ADHD. World Federation of ADHD. 25 - 28 April 2019, Lisbon, Portugal. 2019. |
| Researcher : Wong SN |
| List of Research Outputs |
| WENG J., Wong S.N., Xu X., XUAN B., Wang C., Chen R., Sun C.C., Lakerveld R., Kwok P.C.L. and Chow S.F., Cocrystal Engineering of Itraconazole with Suberic acid via Rotary Evaporation and Spray Drying, Crystal Growth & Design. 2019. |
| WENG J., Wong S.N., Wan K.Y., Chow A.H.L. and Chow S.F., Comparative Evaluation of Four Structurally-Related Profens for Nanoparticle Formulation, AAPS PharmSci 360. 2018. |
| Wan K.Y., Wong S.N., Chow S.F. and Chow A.H.L., A Novel Approach for the Fabrication of Nanoparticle Agglomerates for Pulmonary Drug Delivery, AAPS PharmSci 360. 2018. |
| Wan K.Y., Wong S.N., Wong K.W., Chow S.F. and Chow A.H.L., Interplay between Amphiphilic Stabilizers and Cholesterol in the Stabilization of Itraconazole Nanoparticles Prepared by Flash Nanoprecipitation, Molecular Pharmaceutics. 2018, 16: 195-204. |
| Wong S.N., Hu S., Ng W.W., Xu X., Lai K.L., Lee T.W.Y., Chow A.H.L., Sun C.C. and Chow S.F., Cocrystallization of curcumin with benzenediols and benzenetriols via rapid solvent removal, Crystal Growth & Design. 2018, 18: 5534-5546. |
| Wong S.N., Xu X., Dattani R., Kwok P.C.L. and Chow S.F., Crystal Engineering of Novel Pharmaceutical Cocrystal of Itraconazole with Suberic Acid, AAPS PharmSci 360. 2018. |
| Xu X., Wong S.N. and Chow S.F., Characterization of Flurbiprofen-Pyrazinamide Cocrystal Formulation as Potential Combination Therapy for Treating Tuberculosis, AAPS PharmSci 360. 2018. |
| Xu X., Wong S.N., Wan K.Y. and Chow S.F., Investigation of Photostability of Curcumin via Cocrystallization with Polyphenols, AAPS PharmSci 360. 2018. |
| Researcher : Wong YS |
| List of Research Outputs |
| Sing C.W., Wong Y.S., Kiel D.P., Cheung E.Y., Lam K.Y.J., Cheung T.T., Chan E.W., Kung A.W.C., Wong I.C.K. and Cheung C.L., Association of Alendronate and Risk of Cardiovascular Events in Patients With Hip Fracture, Journal of Bone and Mineral Research. 2018, 33: 1422-1434. |
| Researcher : Woo WHC |
| Project Title: | Anticipation of Gut Microbiota in Atheroprotection via TLR5 signaling |
| Investigator(s): | Woo WHC |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2017 |
| Completion Date: | 05/2019 |
| Project Title: | Gut-derived flagellin ameliorates diet-induced dyslipidemia by upregulating apolipoprotein-A1 |
| Investigator(s): | Woo WHC, Xu A |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2018 |
| Project Title: | TLR5 is an obligatory signaling molecule for UCP1 expression in adaptive thermogenesis |
| Investigator(s): | Woo WHC |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2018 |
| Project Title: | TLR5 controls adaptive thermogenesis by posttranscriptional regulation of UCP1 |
| Investigator(s): | Woo WHC, Xu A |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2018 |
| Project Title: | The role of TRIF in atherosclerosis during postmenopause |
| Investigator(s): | Woo WHC |
| Department: | Pharmacology & Pharmacy |
| Source(s) of Funding: | Seed Fund for Basic Research |
| Start Date: | 06/2019 |
| List of Research Outputs |
| CHEUNG J., YIU J.H.C., FUNG W.L., Xu A. and Woo W.H.C., High Fat Diet Protects Against radiation-Induced Damage: a potential benefit from Gut Microbiota, Keystone Symposia on Molecular and Cellular Biology, March 10-14, 2019, Montreal, Quebec, Canada. 2019. |
| Sid V., Siow Y.L., Shang Y., Woo W.H.C. and O K., High-fat diet consumption reduces hepatic folate transporter expression via nuclear respiratory factor-1, Journal of Molecular Medicine. 2018. |
| Woo W.H.C., A novel atheroprotective role of gut microbiota: an unconventional bridging by Toll-like receptor, Asia-Pacific Diabetes and Obesity Study Group Symposium. 2018. |
| Researcher : XUAN B |
| List of Research Outputs |
| Chow S.F., WENG J., XUAN B. and WAN K.Y., How can the challenges faced by nanoparticle-based pulmonary drug formulations be overcome, Therapeutic Delivery. 2019. |
| WENG J., Wong S.N., Xu X., XUAN B., Wang C., Chen R., Sun C.C., Lakerveld R., Kwok P.C.L. and Chow S.F., Cocrystal Engineering of Itraconazole with Suberic acid via Rotary Evaporation and Spray Drying, Crystal Growth & Design. 2019. |
| Researcher : Xu X |
| List of Research Outputs |
| WENG J., Wong S.N., Xu X., XUAN B., Wang C., Chen R., Sun C.C., Lakerveld R., Kwok P.C.L. and Chow S.F., Cocrystal Engineering of Itraconazole with Suberic acid via Rotary Evaporation and Spray Drying, Crystal Growth & Design. 2019. |
| Wong S.N., Hu S., Ng W.W., Xu X., Lai K.L., Lee T.W.Y., Chow A.H.L., Sun C.C. and Chow S.F., Cocrystallization of curcumin with benzenediols and benzenetriols via rapid solvent removal, Crystal Growth & Design. 2018, 18: 5534-5546. |
| Wong S.N., Xu X., Dattani R., Kwok P.C.L. and Chow S.F., Crystal Engineering of Novel Pharmaceutical Cocrystal of Itraconazole with Suberic Acid, AAPS PharmSci 360. 2018. |
| Xu X., Wong S.N. and Chow S.F., Characterization of Flurbiprofen-Pyrazinamide Cocrystal Formulation as Potential Combination Therapy for Treating Tuberculosis, AAPS PharmSci 360. 2018. |
| Xu X., Wong S.N., Wan K.Y. and Chow S.F., Investigation of Photostability of Curcumin via Cocrystallization with Polyphenols, AAPS PharmSci 360. 2018. |
| Researcher : YIU JHC |
| List of Research Outputs |
| CHEUNG J., YIU J.H.C., FUNG W.L., Xu A. and Woo W.H.C., High Fat Diet Protects Against radiation-Induced Damage: a potential benefit from Gut Microbiota, Keystone Symposia on Molecular and Cellular Biology, March 10-14, 2019, Montreal, Quebec, Canada. 2019. |
| Researcher : Yang K |
| List of Research Outputs |
| Ellie A., Bloksgaard M., Sun W.Y., Yang K., Man W.C.A., Xu A., Irmukhamedov A., . Riber L., Wang Y., De Mey J. and Pablo G., Local enrichment of fatty acid-binding protein 4 in the pericardial cavity of cardiovascular disease patients, PLOS ONE. 2018, 13: e0206802. |
| Sun W.Y., Bai B., Luo C., Yang K., LI D., Wu D., Feletou M., Villeneuve N., Zhou Y., Yang J., Xu A., Vanhoutte P.M.G.R. and Wang Y., Lipocalin-2 derived from adipose tissue mediates aldosterone-induced renal injury, Journal of Clinical Investigation Insight. 2018, 3(17): e120196. |
| Researcher : ZHANG P |
| List of Research Outputs |
| KONJA D., ZHANG P., Luo C., Xu A., Vanhoutte P.M.G.R. and Wang Y., Overexpression of SIRT1 in perivascular adipose tissue enhances vasodilatation and prevents adverse arterial remodeling by modulating the crosstalks between mitochondria and endoplasmic reticulum, 13th MOVD /7th EDH 2019, Rotterdam, The Netherlands, May 20-22, 2019. |
| Researcher : ZHANG Y |
| List of Research Outputs |
| LI Y., ZHANG Y. and Wang W., Photoresponsive nanoparticles for targeted drug delivery, 5th International Biomaterials Symposium. 2018. |
| LI Y., ZHANG Y., LONG K. and Wang W., Phototriggered targeting of nanocarriers for drug delivery, 2018 Taiwan-Japan-Korea Trilateral Conference on Nanomedicine. 2018. |
| LI Y., ZHANG Y. and Wang W., Phototriggered targeting of nanocarriers for drug delivery, Nano Research. Springer Nature, 2018, 11: 5424. |
| Leung S.W.S., Cai Y., ZHANG Y., Vanhoutte P.M.G.R., Sun X., Feinberg M.W. and Man R.Y.K., Upregulation of miRNA-17-3p reduces inflammatory responses in rats, The 8th Scientific Meeting of Asian Society for Vascular Biology (ASVB), 2 to 4 November 2018, Shanghai, China. 2018. |
| Wang Z., ZHANG Y., Cao B., Ji Z., Luo W., Zhai S., Zhang D., Wang W., Xing D. and Hu X., Explosible nanocapsules excited by pulsed microwaves for efficient thermoacoustic-chemo combination therapy, Nanoscale. 2018, 11: 1710-1719. |
| ZHANG Y. and Wang W., Polymer prodrug-based nanoreactors activated by light for combined oxidation and chmotherapy, ICMAT 2019, June 23-28, 2019 Singapore. 2019. |
| ZHANG Y., LI J., LI Y., GE Z. and Wang W., Stimuli-responsive polymeric nanoreactors for cancer therapy , 3rd Asian University Symposium for Biomedical Engineering. 2018. |
| Researcher : ZHANG Y |
| List of Research Outputs |
| LI Y., ZHANG Y. and Wang W., Photoresponsive nanoparticles for targeted drug delivery, 5th International Biomaterials Symposium. 2018. |
| LI Y., ZHANG Y., LONG K. and Wang W., Phototriggered targeting of nanocarriers for drug delivery, 2018 Taiwan-Japan-Korea Trilateral Conference on Nanomedicine. 2018. |
| LI Y., ZHANG Y. and Wang W., Phototriggered targeting of nanocarriers for drug delivery, Nano Research. Springer Nature, 2018, 11: 5424. |
| Leung S.W.S., Cai Y., ZHANG Y., Vanhoutte P.M.G.R., Sun X., Feinberg M.W. and Man R.Y.K., Upregulation of miRNA-17-3p reduces inflammatory responses in rats, The 8th Scientific Meeting of Asian Society for Vascular Biology (ASVB), 2 to 4 November 2018, Shanghai, China. 2018. |
| Wang Z., ZHANG Y., Cao B., Ji Z., Luo W., Zhai S., Zhang D., Wang W., Xing D. and Hu X., Explosible nanocapsules excited by pulsed microwaves for efficient thermoacoustic-chemo combination therapy, Nanoscale. 2018, 11: 1710-1719. |
| ZHANG Y. and Wang W., Polymer prodrug-based nanoreactors activated by light for combined oxidation and chmotherapy, ICMAT 2019, June 23-28, 2019 Singapore. 2019. |
| ZHANG Y., LI J., LI Y., GE Z. and Wang W., Stimuli-responsive polymeric nanoreactors for cancer therapy , 3rd Asian University Symposium for Biomedical Engineering. 2018. |
| Researcher : Zhao J |
| List of Research Outputs |
| Lam L., Anand S., Li X., Tse M.L., Zhao J. and Chan E.W.Y., Efficacy and safety of naltrexone for amfetamine and methamfetamine use disorder: A systematic review of randomized controlled trials. , Clin Toxicology. 2018, 57(4): 225-233. |