School of Biomedical Sciences

SCHOOL OF BIOMEDICAL SCIENCES

Researcher : AN L

List of Research Outputs

AN L., DONG C., LI J., CHEN J., Yuan J., Huang J., Chan K.M., Yu C. and Huen M.S.Y., RNF169 limits 53BP1 deposition at DSBs to stimulate single-strand annealing repair, Proc Natl Acad Sci U S A. 2018, 115(35): E8266-E8295.

AN L., Role of Ring Finger Protein 169 in DNA Double Strand Break Signaling and Repair (PhD Thesis), The University of Hong Kong. 2018.

Researcher : ARYA S

List of Research Outputs

ARYA S., LIN Q. and Huang J., mRNA therapeutics: a different vision, 23rd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2018.

ARYA S., Lin Q., Zhou N. and Huang J., mRNA therapeutics, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

Researcher : Au YK

Project Title:	Engineering Multicellular Self-Organisation III; Mini-Spine: an Ex-vivo Mouse Model System for Functional Studies on the Notochord and Nucleus Pulposus
Investigator(s):	Au YK
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2018
Completion Date:	09/2018

List of Research Outputs

Cheah K.S.E., Szeto Y.Y., Chu D.K.H., Au Y.K., Huang Y.H., Wynn S.L., Mak A.C.Y., Chan Y.S., Chan W.Y., Jauch R., Fritzsch B., Lovell-Badge R.H. and Sham M.H., Dual modes of cooperative repression by SOX9 and SOX10 and SOX9 transactivation of genes essential for inner ear fluid homeostasis maintain hearing., Gordon Research Conference on Neural Crest and Cranial Placodes. 2019.

Cheah K.S.E., Guo S., Chen P., Au Y.K., Niu B., Wu R., Cheung K.M.C., Cheung J.P.Y., Sakai D., Chan D., Zhang M.Q., Richardson S. and Hoyland J., Insights into the cellular basis of intervertebral disc disease gained from the transcriptomes of single cells., Gordon Research Conference on Cartilage Biology and Pathology.. 2019.

GUO S., Chen P., Tan Z., Au Y.K., Niu B., Tam V., Cheung K.M.C., Cheung J.P.Y., Chan D., Sham P.C., Sakai D., Rickardson S., Hoyland J. and Cheah K.S.E., Single cell analyses of human intervertebral discs implicate HOPX as a regulator of homeostasis, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

Researcher : BADEA S-R

List of Research Outputs

BADEA S.-.R., RONG L., LIU R., SUN H., WU W. and Huang J., Overcoming CSPG-mediated inhibition by targeting PTPσ in experimental models of multiple sclerosis, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

Researcher : BHUYAN SK

List of Research Outputs

FRASER L.A., Cheung Y.W., Kinghorn A.B., Guo W., SHIU C.C., JINATA C., LONG F., BHUYAN S.K., Nan L., Shum H.C. and Tanner J.A., Microfluidic Technology for Nucleic Acid Aptamer Evolution and Application, Advanced Biosystems. 2019, 3: 1900012.

Researcher : Badea S

List of Research Outputs

Badea S., Sun H., Wu W. and Huang J., Overcoming CSPG-mediated inhibition by targeting PTPσ in experimental models of multiple sclerosis, 23rd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2018.

Researcher : Ballard HJ

Project Title:	The role of cystic fibrosis transmembrane conductance regulator in the heart
Investigator(s):	Ballard HJ
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017
Completion Date:	05/2019

Project Title:	CFTR-regulated ATP release in the heart
Investigator(s):	Ballard HJ
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research for Resubmission of GRF/ECS Proposals
Start Date:	07/2018
Completion Date:	11/2018

Project Title:	Europhysiology 2018; ATP release from cardiomyocytes involves cystic fibrosis transmembrane conductance regulator (CFTR), pannexin1 (Panx1), Ca signaling and mitochondria
Investigator(s):	Ballard HJ
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2018
Completion Date:	09/2018

List of Research Outputs

Ballard H.J. and WANG Y., Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Induces ATP Formation and Release by Regulating Acid-base Transition and Mitochondrial Oxidative phosphorylation in the Heart, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

LI C., Huang L., Sun W., Chen Y., He M.L., Yue J. and Ballard H.J., Saikosaponin D inhibits autophagy to suppress enterovirus A71 infection, Signal Transduction and Targeted Therapy. Nature, 2019, 4: Article 4.

Researcher : Bao S

List of Research Outputs

Bao S., Jia L., Zhou X., ZHANG Z., Wu W.L., Yu Z., NG G.C.T., Fan Y., Wong S.M., Huang S., To K.K.W., Yuen K.Y., Yeung M.L. and Song Y., Integrated analysis of mRNA-seq and miRNA-seq for host susceptibilities to influenza A (H7N9) infection in inbred mouse lines, Functional & Integrative Genomics. 2018, 18: 411-424.

Wang B., Bao S., ZHANG Z., ZHOU X., WANG J., Fan Y., Zhang Y., Li Y., Chen L.P., Jia Y., LI J., Li M., Zheng W., Mu N., Yang W., Yu Z., Lau D.S.S., Wong S.M., ZHANG Y., Kwan J.S.K., Mak H.K.F., Ambalavanan A., Zhou S., Cai W., Zheng J., Huang S., Rouleau G.A., Yang W., Rogaeva E., Ma X., St George-Hyslop P., Chu L.W. and Song Y., A rare variant in MLKL confers susceptibility to ApoE ɛ4-negative Alzheimer's disease in Hong Kong Chinese population, Neurobiol Aging. 2018, 68:160: e1-e7.

ZHANG Z., Bao S., WANG B.B., MA X. and Chu L.W., MLKL Loss-of-Function Variant Increases Alzheimer’s Disease Risk Through Modulating γ-Secretase Activity, 2019 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2019.

Researcher : CAO F

List of Research Outputs

CHEN Y., LI J., CAO F., Lam J., Cheng C.C.Y., Yu C. and Huen M.S.Y., Nucleolar residence of the seckel syndrome protein TRAIP is coupled to ribosomal DNA transcription, Nucleic Acids Research. 2018, 46: 10119-10131.

ZHOU Y., CAO F. and Yu C., PIK3CB and PTEN control macrophage podosome assembly, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

Zhang Y., Cao F., Zhou Y., Feng Z., Sit B., Krendel M. and Yu C., Tail domains of myosin-1e regulate phosphatidylinositol signaling and F-actin polymerization at the ventral layer of podosomes, Molecular Biology of the Cell. 2019, mbc.E18-06-0398.

Researcher : CHAN CK

List of Research Outputs

CHAN C.K., Wong Y.S., Jiang Z., Zhou Z. and Lee C.W., Podosome-directed MT1-MMP trafficking and surface insertion regulate AChR clustering and remodeling at developing NMJs, 2019 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2019.

Lin W., Yip Y.L., Jia L.J., Deng W., Zheng H., Dai W., Ko J.M.Y., Lo K.W., Chung G.T.Y., Yip K.Y., Lee S.D., Kwan J.S.H., Zhang J., Liu T.F., Chan Y.W., Kwong D.L.W., Lee V.H.F., Nicholls J.M., Busson P., Liu X.F., Chiang A.K.S., Hui K.F., Kwok H., Cheung S.T., Cheung Y.C., Chan C.K., Li B., Cheung A., Hau P.M., Zhou Y., Tsang C.M., Middeldorp J., Chen H., Lung M.L. and Tsao G.S.W., Establishment and characterization of new tumor xenografts and cancer cell lines from EBV-positive nasopharyngeal carcinoma, Nature Communications. 2018, 7; 9(1): 4663.

Researcher : CHAN HL

List of Research Outputs

FAN R., TAM K.K., CHAN H.L., Huang J. and Lai K.O., Elucidating the non-redundant role of different Kinesin 1 motor proteins in dendritic mRNA transport of neuron, 2019 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2019.

FAN R., CHAN H.L., Huang J. and Lai K.O., Elucidating the non-redundant role of different Kinesin 1 motor proteins in dendritic mRNA transport of neuron, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

Researcher : CHAN KC

List of Research Outputs

CHAN K.C. and Wong S.L., Discovering druggable gene combinations for Parkinson's disease by CombiGEM CRISPR, 2019 Synthetic Biology: Engineering, Evolution and Design (SEED). 2019.

CHAN K.C. and Wong S.L., Discovering druggable gene combinations for Parkinson’s disease by CombiGEM-CRISPR, 23rd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2018.

Researcher : CHAN LH

List of Research Outputs

CHAN L.H., Zhou L., Ng K.Y., Wong T.L., Lee T.K., Sharma R., LOONG H.C., Ching Y.P., Yuan Y.F., Xie D., Lo C.M., Man K., Artegiani B., Clevers H., Yan H.H.N., Leung S.Y., Richard S., Guan X., Huen M.S.Y. and Ma S.K.Y., Protein arginine methyltransferase PRMT6 regulates RAS/RAF binding and MEK/ERK-mediated cancer stemness activities in hepatocellular carcinoma through CRAF methylation, Cell Reports. 2018.

Researcher : CHAN SF

List of Research Outputs

CHAN S.F., Pearson B. and Chan D., Basement membrane regulates adult pluripotent stem cell fates in planarian, 23rd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2018.

Researcher : CHAUDHARY V

List of Research Outputs

. S., Yuen K.S., CHAUDHARY V., Botelho M.G. and Jin D., Dysregulation of innate interferon signaling by Epstein-Barr virus tegument protein BGLF2, IMMUNOLOGY 2019: Annual Meeting of The American Association of Immunologists, San Diego, California, USA. 2019.

Wang F., Ye Z., Deng J., Siu K.L., Gao W., Chaudhary V., Cheng Y., Fung S.Y., Yuen K.S., Ho T.H., Chan C.P., Zhang Y., Kok K.H., Yang W., Chan C.P. and Jin D., Inhibition of AIM2 inflammasome activation by a novel transcript isoform of IFI16. , EMBO reports. 2018.

Ye Z., CHAUDHARY V., Chan J.F.W. and Jin D., Activation of interferon-γ signaling by SFTS virus NSs protein, Keystone Symposium on “Framing the Response to Emerging Virus Infections, Pokfulam, Hong Kong. 2018.

Researcher : CHE N

List of Research Outputs

CHE N., Ng K.Y., Tong M., Lui Kau W.F., Huen M.S.Y., Guan X. and Ma S.K.Y., Functional and Mechanistic Characterisation of PRMT6-regulated Autophagy in Hepatocellular Carcinoma, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

CHE N., Ng K.Y., Tong M., Lui Kau W.F., Guan X., Huen M.S.Y. and Ma S.K.Y., Functional and mechanistic characterization of PRMT6-regulated autophagy in hepatocellular carcinoma, 23rd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2018.

CHE N., Ng K.Y., Tong M., Lui Kau W.F., Guan X., Huen M.S.Y. and Ma S.K.Y., Protein arginine methylation by PRMT6 regulates autophagy in hostile microenvironment of hepatocellular carcinoma tumours, 2019 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2019.

CHE N., Ng K.Y., Tong M., Lui Kau W.F., Guan X., Huen M.S.Y. and Ma S.K.Y., Protein arginine methylation by PRMT6 regulates autophagy in hostile microenvironment of hepatocellular carcinoma tumours, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

Researcher : CHEN J

List of Research Outputs

AN L., DONG C., LI J., CHEN J., Yuan J., Huang J., Chan K.M., Yu C. and Huen M.S.Y., RNF169 limits 53BP1 deposition at DSBs to stimulate single-strand annealing repair, Proc Natl Acad Sci U S A. 2018, 115(35): E8266-E8295.

CHEN X., ZHU S., Zhenin M., XU W., Bose S.J., Wong P.F., Leung G.P.H., Senderowitz H. and Chen J., A defective flexible loop contributes to the processing and gating defects of the predominant cystic fibrosis–causing mutation, The FASEB Journal. 2019, 33: 5126-5142.

Researcher : CHEN X

List of Research Outputs

CHEN X., ZHU S., Zhenin M., XU W., Bose S.J., Wong P.F., Leung G.P.H., Senderowitz H. and Chen J., A defective flexible loop contributes to the processing and gating defects of the predominant cystic fibrosis–causing mutation, The FASEB Journal. 2019, 33: 5126-5142.

CHEN X., Kwan J.S.K., Ma A.C.H. and Chang R.C.C., Inhibition of melanogenesis alters autophagy in zebrafish (Danio rerio), The 14th International Symposium on Healthy Aging. 2019, 57.

CHEN X., Hasan K.M.M., Kwan J.S.K., Ma A.C.H. and Chang R.C.C., Systemic inflammation induces IL-1b-mediated microglia invasion in the Zebrafish brain, The 14th International Symposium on Healthy Aging. 2019, 58.

CHEN X., Hasan K.M.M., Kwan J.S.K., Ma A.C.H. and Chang R.C.C., Systemic inflammation induces IL-1β-mediated microglia invasion in the zebrafish brain, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

Researcher : CHEN X

List of Research Outputs

CHEN X., Kwan J.S.K., Ma A.C.H. and Chang R.C.C., Inhibition of melanogenesis alters autophagy in zebrafish (Danio rerio), The 14th International Symposium on Healthy Aging. 2019, 57.

Researcher : CHEN Y

List of Research Outputs

CHEN Y., A Mechanistic Study of TRAIP Mobilisation in UV Response (MPhil Thesis), The University of Hong Kong. 2018.

CHEN Y., LI J., CAO F., Lam J., Cheng C.C.Y., Yu C. and Huen M.S.Y., Nucleolar residence of the seckel syndrome protein TRAIP is coupled to ribosomal DNA transcription, Nucleic Acids Research. 2018, 46: 10119-10131.

Researcher : CHENG T

List of Research Outputs

Jin D., CHENG T., HUNG T.N., Kong K.Y. and Chan C.P., Suppression of hepatitis B virus transcription by RFWD2 ubiquitin ligase, 2018 International HBV Meeting: The Molecular Biology of Hepatitis B Viruses. Palazzo dei Congressi, Piazza Vittorio Emanuele Taormina (Messina), Italy, October 3-6, 2018.. 2018.

Kong K.Y., CHENG T. and Jin D., The chromatin architectural protein CTCF binds to HBV cccDNA and promotes its transcription, 2018 International HBV Meeting: The Molecular Biology of Hepatitis B Viruses. Palazzo dei Congressi, Piazza Vittorio Emanuele Taormina (Messina), Italy, October 3-6, 2018.. 2018.

Researcher : CHENG TF

List of Research Outputs

Jin D., CHENG T.F., HO T.H. and Yuen K.S., Caspase 3 activation facilitates Epstein-Barr virus lytic replication in epithelial cells, 2018 International Conference on EBV & KSHV. University of Wisconsin – Madison, Wisconsin, USA, July 28 to August 1, 2018.. 2018.

Researcher : CHEUNG CC

List of Research Outputs

CHEUNG C.C. and Lam W.L., 3D printing for the improvement of patient consultation and consent in hand surgery, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

Researcher : CHEUNG MH

List of Research Outputs

CHEUNG M.H., JIANG Q., Wu L.K., Shum D.K.Y. and Chan Y.S., Fluoxetine activated ependymal stem cells and induces genesis of parvalbumin-expressing interneurons in the juvenile medial vestibular nuclei, Abstracts of 14^th International Symposium on Healthy Aging. 2019, P60.

Researcher : CHEUNG PHH

List of Research Outputs

CHEUNG P.H.H. and Jin D., Influenza A virus PB1-F2 protein suppresses IL-1β production from human macrophages by enhancing MAVS degradation, American Society for Virology Travel Award. 2018.

CHEUNG P.H.H., Fung S.Y., Yuen K.Y., Chen H. and Jin D., Influenza A virus PB1-F2 protein suppresses IL-1β production from human macrophages by enhancing MAVS degradation, The American Society for Virology 37th Annual Meeting, University of Maryland, College Park, Maryland, USA, July 14-18, 2018.. 2018.

CHEUNG P.H.H., PB1-F2 protein of highly pathogenic avian influenza A (H7N9) virus suppresses MAVS-mediated antiviral responses through enhancing MAVS degradation (PhD Thesis), The University of Hong Kong. 2018.

Chan C.P., Yuen C.K.J., CHEUNG P.H.H., Fung S.Y., Lui P.Y., Chen H., Kok K.H. and Jin D., Antiviral activity of double-stranded RNA–binding protein PACT against influenza A virus mediated via suppression of viral RNA polymerase, The FASEB Journal. 2018, 32: 4380-4393.

Fung S.Y., Cheung P.H.H., Chan C.P. and Jin D., Perturbation of innate DNA sensing by human RNA viruses., The 7th Cross Straight Immunology Conference. 2018.

Researcher : CHEUNG WL

List of Research Outputs

CHEUNG W.L., MA S.K.Y. and Chan D., Stem cell response to biomechanical changes in planarian regeneration, 23rd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2018.

Researcher : CHOW WH

List of Research Outputs

CHOW W.H., Neuron-astroglial communications: NMDA-induced proheparanase modulation of synaptic strength (PhD Thesis), The University of Hong Kong. 2018.

Researcher : CHU TL

List of Research Outputs

CHU T.L., MMP14 and Regulation of Hypertrophic Chondrocyte to Osteoblast Lineage (PhD Thesis), The University of Hong Kong. 2018.

Researcher : CHUA WH

List of Research Outputs

CHUA W.H., Impact of Neuromodulators on the Maturation and Rewiring of Neural Circuitry for Vestibular-dependent Behaviors, The University of Hong Kong. 2019.

Researcher : CHUNG WH

List of Research Outputs

CHUNG W.H., A Structural Approach to Protein Intrinsic Versatility - the Tale of Succinyllysine Reader GAS41 and Palmitoyllysine Eraser SIRT3 (MPhil Thesis), The University of Hong Kong. 2018.

Researcher : CUI D

List of Research Outputs

CUI D., Han L., ZHU Y., YAN D., Tsao G.S.W. and Cheung A., Role and mechanism of miR-338-5p in regulating metastasis of esophageal cancer, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

Researcher : Cai S

List of Research Outputs

Wong Y.C., Tam K.W., Cai S., Shum D.K.Y. and Chan Y.S., Towards autologous transplantation and remyelination therapy with use of human bone marrow stromal cell-derived Schwann cells, Abstracts of 14^th International Symposium on Healthy Aging. 2019, P62.

Researcher : Cecot TS

List of Research Outputs

Cecot T.S., Anatomical Terminology, The University of Hong Kong. 2019.

Cecot T.S., Practical approach to educational theories , Ideatorium 2019, 6th Annual Meeting; Gdansk, Poland. 2019.

See C.Y.H., Cecot T.S., Choi P.H., Ng L.S. and Siu M.F.P., Functional Anatomy Training: An interdisciplinary approach to enhancing student wellbeing in health professions education., Bridging the Gap: Translating Interdisciplinary Research into Evidence-Based Practice, Hong Kong Shue Yan University 2019.

Researcher : Chai A

List of Research Outputs

LIN L., LYU Q., Shen X., ZHAO J., Chai A. and Lai K.O., The epilepsy gene tbc1d24 encodes a novel synaptic protein that is required for the maintenance of excitatory synapses in hippocampal neuron, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

LIN L., LYU Q., Shen X., ZHAO J., Chai A. and Lai K.O., The epilepsy gene tbc1d24 encodes a novel synaptic protein that is required for the maintenance of excitatory synapses in neuron, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

Shen X., LIN L., LYU Q., ZHAO J., Chai A., Lai C.S., Chan Y.S. and Lai K.O., Impaired cognitive function and increased seizure susceptibility in mice depleted of the signalling protein TBC1D24, Abstracts of 14th International Symposium on Healthy Aging –Embrace the Golden Years : [HK. March 16-17, 2019]. 2019, P15.

Researcher : Chan CK

List of Research Outputs

Researcher : Chan CP

List of Research Outputs

Chan C.P., Yuen C.K.J., CHEUNG P.H.H., Fung S.Y., Lui P.Y., Chen H., Kok K.H. and Jin D., Antiviral activity of double-stranded RNA–binding protein PACT against influenza A virus mediated via suppression of viral RNA polymerase, The FASEB Journal. 2018, 32: 4380-4393.

Fung S.Y., Chan C.P., Zhu L., Yuen K.Y., Woo P.C.Y., Cai Z. and Jin D., Middle East respiratory syndrome coronavirus ORF4b protein targets cGAS-STING pathway of nucleic acid sensing., Keystone Symposium on “Framing the Response to Emerging Virus Infections“, Pokfulam, Hong Kong. 2018.

Fung S.Y., Cheung P.H.H., Chan C.P. and Jin D., Perturbation of innate DNA sensing by human RNA viruses., The 7th Cross Straight Immunology Conference. 2018.

Jin D., Chan C.P., Fung S.Y., Yuen K.S. and Chan C.P., Anti-HTLV-1 activity of SAMHD1 in resting T cells, HTLV 2019: 19th International Conference on Human Retrovirology, Lima, Peru. 2019.

Jin D., CHENG T., HUNG T.N., Kong K.Y. and Chan C.P., Suppression of hepatitis B virus transcription by RFWD2 ubiquitin ligase, 2018 International HBV Meeting: The Molecular Biology of Hepatitis B Viruses. Palazzo dei Congressi, Piazza Vittorio Emanuele Taormina (Messina), Italy, October 3-6, 2018.. 2018.

WONG L.Y.R., Lui P.Y., Siu K.L., Yeung M.L., Yuen K.S., Fung S.Y., Chan C.P., Woo P.C.Y., Yuen K.Y. and Jin D., Middle-East respiratory syndrome coronavirus ORF8b protein suppresses type I interferon production by interacting with HSP70, The American Society for Virology 37th Annual Meeting, University of Maryland, College Park, Maryland, USA, July 14-18, 2018.. 2018.

WONG L.Y.R., Ye Z., Lui P.Y., Siu K.L., Yeung M.L., Yuen K.S., Fung S.Y., Chan C.P., Cai Z., Woo P.C.Y., Yuen K.Y. and Jin D., Suppression of type I interferon production by Middle East respiratory syndrome coronavirus ORF8b accessory protein through interaction with HSP70 chaperone, Keystone Symposium on “Framing the Response to Emerging Virus Infections”, Pokfulam, Hong Kong. 2018.

Wang F., Ye Z., Deng J., Siu K.L., Gao W., Chaudhary V., Cheng Y., Fung S.Y., Yuen K.S., Ho T.H., Chan C.P., Zhang Y., Kok K.H., Yang W., Chan C.P. and Jin D., Inhibition of AIM2 inflammasome activation by a novel transcript isoform of IFI16. , EMBO reports. 2018.

Wang F., Ye Z., Chan C.P. and Jin D., Putting a brake on inflammasome activation by reprogramming transcription from an alternative promoter: IFI16 as an example, 11th International Singapore Symposium of Immunology, Singapore. 2019.

Researcher : Chan CP

Project Title:	Regulation of hepatitis B virus transcription by PRMT5 protein arginine methyltransferase
Investigator(s):	Chan CP, Zhou J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	08/2015
Completion Date:	12/2018

Project Title:	Characterization of a novel b-TrCP ubiquitin ligase-dependent mechanism for ubiquitination and degradation of liver-enriched transcription factor CREB-H
Investigator(s):	Chan CP, Yuen KS, Lui PY
Department:	School of Biomedical Sciences
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - Science Fund for Young Scholars
Start Date:	01/2016

Project Title:	Roles of Middle East respiratory syndrome coronavirus ORF8b protein in Type I interferon antagonism
Investigator(s):	Chan CP
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017

Project Title:	Identification and characterization of a novel CREB-H target implicating in liver fibrosis
Investigator(s):	Chan CP
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2019

List of Research Outputs

Fung S.Y., Cheung P.H.H., Chan C.P. and Jin D., Perturbation of innate DNA sensing by human RNA viruses., The 7th Cross Straight Immunology Conference. 2018.

Jin D., Chan C.P., Fung S.Y., Yuen K.S. and Chan C.P., Anti-HTLV-1 activity of SAMHD1 in resting T cells, HTLV 2019: 19th International Conference on Human Retrovirology, Lima, Peru. 2019.

Researcher : Chan D

Project Title:	Genome-wide identification and functional studies of genetic risk factors for low back pain and intervertebral disc degeneration
Investigator(s):	Chan D
Department:	School of Biomedical Sciences
Source(s) of Funding:	AOSpine International - General Award
Start Date:	08/2007

Project Title:	Research Output Prize (Li Ka Shing Faculty of Medicine)
Investigator(s):	Chan D
Department:	School of Biomedical Sciences
Source(s) of Funding:	Research Output Prize (in Faculty)
Start Date:	12/2010

Project Title:	Interplay between ER stress and hypoxic stress in the regulation of chondrocyte differentiation
Investigator(s):	Chan D, Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2012

Project Title:	Integrative Approaches to Understanding Disorders of the Skeleton
Investigator(s):	Chan D
Department:	School of Biomedical Sciences
Source(s) of Funding:	Croucher Advanced Study Institute
Start Date:	12/2013

Project Title:	IHH regulating CDO/GAS1 function in synovial joint formation
Investigator(s):	Chan D, Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2017

Project Title:	Understanding hyperplastic callus and abnormal bone formation in osteogenesis imperefecta type V
Investigator(s):	Chan D, To MKT, Gao B
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2018

Project Title:	Establishment of a Transgenic Core Facility for generation of genetically modified mice
Investigator(s):	Chan D
Department:	School of Biomedical Sciences
Source(s) of Funding:	Small Equipment Grant
Start Date:	04/2018

Project Title:	Molecular basis of Asporin as a genetic risk factor for intervertebral disc degeneration
Investigator(s):	Chan D, Cheah KSE, Gao B
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2019

Project Title:	Induced pluripotent stem cell-based therapy for spinal regeneration (iPSpine)
Investigator(s):	Chan D, Liu P
Department:	School of Biomedical Sciences
Source(s) of Funding:	European Union (EU) – Hong Kong Research and Innovation Cooperation Co-funding Mechanism by the RGC
Start Date:	04/2019

Project Title:	Ligament and tendon repair using Lgr5+ interzone cells as progenitor
Investigator(s):	Chan D, Yau WP, Gao B, Sham PC
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2019

Project Title:	Exploiting the true joint progenitor cell for articular cartilage repair
Investigator(s):	Chan D, Liu P, Sham PC
Department:	School of Biomedical Sciences
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2019

List of Research Outputs

CHAN S.F., Pearson B. and Chan D., Basement membrane regulates adult pluripotent stem cell fates in planarian, 23rd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2018.

CHEUNG W.L., MA S.K.Y. and Chan D., Stem cell response to biomechanical changes in planarian regeneration, 23rd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2018.

Cheah K.S.E., Guo S., Chen P., Au Y.K., Niu B., Wu R., Cheung K.M.C., Cheung J.P.Y., Sakai D., Chan D., Zhang M.Q., Richardson S. and Hoyland J., Insights into the cellular basis of intervertebral disc disease gained from the transcriptomes of single cells., Gordon Research Conference on Cartilage Biology and Pathology.. 2019.

GUO S., Chen P., Tan Z., Au Y.K., Niu B., Tam V., Cheung K.M.C., Cheung J.P.Y., Chan D., Sham P.C., Sakai D., Rickardson S., Hoyland J. and Cheah K.S.E., Single cell analyses of human intervertebral discs implicate HOPX as a regulator of homeostasis, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

Vimalagopalan D., Kwon Y.J.S., Chan W.C.W. and Chan D., Role of Pax1 in the etiology of adolescent idiopathic scoliosis, 23rd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2018.

Wang C., Tan Z., Niu B., Tsang K.Y., Tai C.P., Chan W.C.W., Lo R.L.K., Leung K.K.H., Dung W.F., Itoh N., Zhang M.Q., Chan D. and Cheah K.S.E., Inhibiting the integrated stress response pathway prevents aberrant chondrocyte differentiation thereby alleviating chondrodysplasia, eLife. 2018, 7: e37673.

Yip K.H.R., Chan D. and Cheah K.S.E., Mechanistic insights into skeletal development gained from genetic disorders, Curr Top Dev Biol. 2019, 133: 343-385.

Zhou X., Cheung C.L., Karasugi T., Karppinen J., Samartzis D., Hsu Y.H., Mak S.H.T., Song Y., Chiba K., Kawaguchi Y., LI Y., Chan D., Cheung K.M.C., Ikegawa S., Cheah K.S.E. and Sham P.C., Trans-ethnic polygenic analysis supports genetic overlap of lumbar disc degeneration with height, body mass index, and bone mineral density., Frontiers in Genetics. 2018.

Researcher : Chan LK

Project Title:	Perception by LKS Faculty of Medicine graduates on their university education
Investigator(s):	Chan LK, Ip MSM, Patil NG, Prosser MT
Department:	Bau Institute of Medical and Health Scie
Source(s) of Funding:	Teaching Development Grants
Start Date:	06/2008

Project Title:	Assessing competency of dental graduates from problem-based learning and traditional curriculums: Graduates’ and Employers’ Perceptions
Investigator(s):	Chan LK, Yiu CKY, Botelho MG, Bridges SM, Corbet EF, Dyson JE, McGrath CPJ, Wong WKR, Prosser MT
Department:	Bau Institute of Medical and Health Scie
Source(s) of Funding:	Teaching Development Grants
Start Date:	12/2008

List of Research Outputs

Bridges S.M., Chan L.K., Green J.L., Saleh A. and Hmelo-Silver C., Dialogic Intervisualizing: Rethinking Text-Discourse-Learning Relations in Multimodal Problem-based Learning, 13th CSCL 2019. Lyon, France.

Bridges S.M., Law N.W.Y., Li L. and Chan L.K., Evaluating Multimodal Learning Designs for Health Professions Education Advanced Degree Programs, 2019 AERA Annual Meeting. Toronto, Canda, 2019.

Chan L.K., Research and publishing in basic biomedical teaching and learning, Annual Conference of the Teaching Steering Committee of Basic Medical Sciences, Ministry of Education. Shiyan, Hubei, China . 2018.

Chan L.K., The use of technology to promote active learning in the gross anatomy laboratory. , The 5th International Anatomical Sciences & Cell Biology Conference 2018. Kuala Lumpur, Malaysia.. 2018.

Lam C.S.N., Chan L.K. and See C.Y.H., Converse, Connect and Consolidate – The Development of an Artificial Intelligence Chatbot for Health Sciences Education., Frontiers in Medical and Health Sciences Education Conference 2018, Hong Kong.. 2018.

See C.Y.H., Lam C.S.N., Li Y.S. and Chan L.K., Methods for training an AI for Higher Education, Centre for Information Technology in Education Annual Research Symposium (CITERS 2019), HKU. 2019.

Researcher : Chan WCW

Project Title:	Oligonucleotide aptamers for the treatment of low bone mass disorders
Investigator(s):	Chan WCW, Chan D, Tanner JA, To MKT
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2019

List of Research Outputs

Vimalagopalan D., Kwon Y.J.S., Chan W.C.W. and Chan D., Role of Pax1 in the etiology of adolescent idiopathic scoliosis, 23rd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2018.

Wang C., Tan Z., Niu B., Tsang K.Y., Tai C.P., Chan W.C.W., Lo R.L.K., Leung K.K.H., Dung W.F., Itoh N., Zhang M.Q., Chan D. and Cheah K.S.E., Inhibiting the integrated stress response pathway prevents aberrant chondrocyte differentiation thereby alleviating chondrodysplasia, eLife. 2018, 7: e37673.

Researcher : Chan YS

Project Title:	30th Annual Conference of Society for Neuroscience Expression of N-Methyl-D-Aspartate Receptor Subunits and Induction of c-fos in Otolith Neurons in the Vestibular Nuclei of Postnatal Rats
Investigator(s):	Chan YS
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2000

Project Title:	31st Annual Meeting of Society for Neuroscience Expression of Neurotrophin Receptors in Vestibular Nuclei During the Postnatal Development of the Rat
Investigator(s):	Chan YS
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2001

Project Title:	XXIV Annual Conference of Indian Academy of Neurosciences Development Refinement of Spatial Recognition Circuits
Investigator(s):	Chan YS
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	12/2006

Project Title:	Role of the thalamus in integrating spatial information and guiding navigation
Investigator(s):	Chan YS
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2009

Project Title:	Outstanding Research Student Supervisor Award 2009-10
Investigator(s):	Chan YS
Department:	School of Biomedical Sciences
Source(s) of Funding:	Outstanding Research Student Supervisor Award
Start Date:	12/2010

Project Title:	Orexin-induced modulation of activity-dependent synaptic plasticity is critical for the maturation of vestibular circuitry and functions
Investigator(s):	Chan YS, Shum DKY, Lai CH
Department:	School of Biomedical Sciences
Source(s) of Funding:	NSFC/RGC Joint Research Scheme
Start Date:	01/2015
Completion Date:	12/2018

Project Title:	Neuronal Mechanism of Cholecystokinin-Facilitated Cross-modal Learning and Memory
Investigator(s):	Chan YS
Department:	School of Biomedical Sciences
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2016

Project Title:	Remodeling the sulfation pattern of perineuronal nets in the entorhinal cortical circuit prevents stress-induced decline in learning and memory
Investigator(s):	Chan YS, Lai SWC, Shum DKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

Project Title:	Integration of new neurons into the mature vestibular circuitry requires GABAergic signaling for relevant outcome in behavior
Investigator(s):	Chan YS, Lai SWC, Shum DKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2016

Project Title:	HKU Centennial Distinguished Chinese Scholars Scheme 2016-17
Investigator(s):	Chan YS
Department:	School of Biomedical Sciences
Source(s) of Funding:	HKU Centennial Distinguished Chinese Scholars Scheme
Start Date:	09/2016

Project Title:	Selective recruitment of inhibitory interneurons to vestibular microcircuits for distinct behaviour
Investigator(s):	Chan YS, Lai SWC, Shum DKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2017

Project Title:	Overcoming hurdles in bridging critical nerve gaps to improve post-traumatic nerve regeneration and rehabilitation
Investigator(s):	Chan YS, Cai S, Shum DKY, Shea GKH, Tu W
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2018

Project Title:	Strategies to re-open plasticity in the central vestibular circuitry for rescuing disability in spatial learning (CRF)
Investigator(s):	Chan YS
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Funding for Strategic Interdisciplinary Research Scheme
Start Date:	04/2018

Project Title:	Surface hyaluronidase-4 derivatized oligodendrocyte precursor cells for repairing inflammation-induced impairment in the CNS
Investigator(s):	Chan YS, Shum DKY, Lai KO
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2019

List of Research Outputs

CHEUNG M.H., JIANG Q., Wu L.K., Shum D.K.Y. and Chan Y.S., Fluoxetine activated ependymal stem cells and induces genesis of parvalbumin-expressing interneurons in the juvenile medial vestibular nuclei, Abstracts of 14^th International Symposium on Healthy Aging. 2019, P60.

Chan Y.S., Ma C.W., Shi W. and Shum D.K.Y., Cannabinoid receptor suppresses long-term depression in the neonatal brain for consolidation of neuronal circuits for spatial cognition, Soc. Neuroscience Abstract (USA) 36.08 [San Diego. Nov. 3-7, 2018]. 2018, 36.08.

Chan Y.S., LAM T.F., JIANG Y., Wu L.K., Ma C.W. and Wang J.J., Orexin delays activity-dependent maturation of the vestibular system in rats, Abstracts of 11^th FENS Forum of Neuroscience. 2018, 691.

Chan Y.S., KWAN P.Y., Tam K.W., Ma C.W., Wu L.K. and Shum D.K.Y., Perineuronal net and semaphorin regulate developmental plasticity of the central vestibular circuitry for sensori-motor function, Abstracts of 15^th Conference of Asia-Pacific Society for Neurochemistry. 2018, 82.

Chan Y.S., Wu L.K., JIANG Q., Ma C.W. and Shum D.K.Y., Postnatal refinement of circuit plasticity for spatial navigation, Proc. 9^th Congress of Federation of Asian-Oceanian Physiological Societies [Kobe. March 28-31, 2019]. 2019, 61.

Cheah K.S.E., Szeto Y.Y., Chu D.K.H., Au Y.K., Huang Y.H., Wynn S.L., Mak A.C.Y., Chan Y.S., Chan W.Y., Jauch R., Fritzsch B., Lovell-Badge R.H. and Sham M.H., Dual modes of cooperative repression by SOX9 and SOX10 and SOX9 transactivation of genes essential for inner ear fluid homeostasis maintain hearing., Gordon Research Conference on Neural Crest and Cranial Placodes. 2019.

Han L. and Chan Y.S., Developmental profile of spontaneous transient outward currents in rat medial vestibular nucleus, Abstracts of 11^th FENS Forum of Neuroscience. 2018, 825.

He L., Zhang N., Zhang Z., Tang P., Su J.F., Hu L.L., Qing L.Q., He X., Tan A., Sun X., Li M., Wong K., Wang X., Cheung H.Y., Shum D.K.Y., Yung K.K., Chan Y.S., Tortorella M., Guo Y.P. and Xu F., Cholecystokinin release triggered by NMDA receptors produces LTP and sound-sound associative memory, Proceedings of National Academy of Sciences USA. 2019, 116: 6397-6406.

Ho S.S., Tam K.W., Shea G.K.H., Shum D.K.Y. and Chan Y.S., Directing polarization of macrophages in enhancing spinal cord repair after injury, Abstracts of 14^th International Symposium on Healthy Aging. 2019, P9.

Hu X., Wu L.K., Chua O.W., Shum D.K.Y. and Chan Y.S., Selective recruitment of inhibitory interneurons to vestibular microcircuits for distinct behaviour, Abstracts of 14^th International Symposium on Healthy Aging: Science and Aging –Embrace the Golden Years: P2. [HK. March 16-17, 2019]. 2019.

JIANG Q. and Chan Y.S., Neurogenesis-dependent restoration of plasticity in the vestibular nucleus of young adult rats by antidepressant, Gordon Research Conference – Recent Discoveries and Technological Advances in the Study of the Nervous System during Development, Health and Diseases. 2018.

KWAN P.Y., Shum D.K.Y. and Chan Y.S., Perineuronal chondroitin sulfates reinforce inhibitory GABAergic transmission in the maturation of sensori-motor function, Matrix Biology Europe 2018. [Manchester, UK. July 21-24, 2018]. 2018.

Koh J., Lim W.L., Zhang C.F., Heng B.C., Neoh J., Hescham S.A., Blokland A., Wu E.X., Chan Y.S., Temel Y. and Lim L.W., Pacemaker in the aged brain: From molecular profiling to memory enhancement, Abstracts of 14^th International Symposium on Healthy Aging –Embrace the Golden Years [HK. March 16-17, 2019]. 2019, P50.

Kwan P.Y., Shum D.K.Y. and Chan Y.S., Perineuronal Chondroitin Sulfates Disruption Interferes Excitation/Inhibition Balance in Developing Vestibular Circuitry, the 14th International Symposium on Healthy Aging . 2019.

Kwan P.Y., Shum D.K.Y. and Chan Y.S., Perineuronal chondroitin sulfates reinforce inhibitory GABAergic transmission in the maturation of sensori-motor function, Matrix Biology Europe 2018.

Kwan T.P., Shum D.K.Y. and Chan Y.S., Perineuronal chondroitin sulfates disruption interferes excitation/inhibition balance in developing vestibular circuitry, Abstracts of 14^th International Symposium on Healthy Aging. 2019, P51.

LYU Q., FAN R., Tsui Y.P., Chan Y.S., Shum D.K.Y. and Lai K.O., ) The use of genome-editing to study the pathophysiological mechanism of brain disorders in human induced pluripotent stem cell (iPSC), Abstracts of 14^th International Symposium on Healthy Aging. 2019, P61.

LYU Q., FAN R., Tsui Y.P., Chan Y.S., Shum D.K.Y. and Lai K.O., A knock-in strategy to study protein localization in human induced pluripotent stem cell (iPSC)-derived cortical neuron through genome editing, 13th Annual Canadian Neuroscience Meeting. 2019.

LYU Q., FAN R., ZHAO J., Tsui Y.P., Chan Y.S., Shum D.K.Y. and Lai K.O., A knock-in strategy to study protein localization in human induced pluripotent stem cell (iPSC)-derived cortical neuron through genome editing, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

Lau Y.T., Kwok L.F., Tam K.W., Chan Y.S., Shum D.K.Y. and Shea G.K.H., Genipin-treated chitosan nanofibers as a novel scaffold for nerve guidance channel design, Colloids and Surface B: Biointerfaces. 2018, 162: 126-134.

Leong T.L., Gu Y., Chan Y.S., Zheng H., DONG M., Chan R.W., WANG X., Liu Y., Tan L.H. and Wu E.X., Optogenetic fMRI interrogation of brain-wide central vestibular pathways, Proceedings of the National Academy of Sciences. NATL ACAD SCIENCES, 2019, 116: 10122-10129.

Lin R., Duan Z., Sun H., Fung M.L., Chen H., Wang J., Lau C.F., Yang D., Liu Y., Ni Y., Wang Z., Cui J., Wu W., Yung W.H., Chan Y.S., Lo A.C.Y., Xia J., Shen J. and Huang J., Kinesin-1 Regulates Extrasynaptic Targeting of NMDARs and Neuronal Vulnerability Toward Excitotoxicity, iScience. 2019, 13: 82-97.

Ma C.W., Kwan T.P., Wu K.L., Shum D.K.Y. and Chan Y.S., Regulatory role of perineuronal nets and semaphorin 3A in the postnatal maturation of the central vestibular circuitry for graviceptive reflex, Brain Structure and Function. 2019, 224: 613-626.

Ma C.W., Kwan P.Y., Wu L.K., Shum D.K.Y. and Chan Y.S., Regulatory roles of perineuronal nets and semaphorin 3A in the postnatal maturation of the central vestibular circuitry for graviceptive reflex, Brain Structure and Function. 2019, 224: 613-626.

NG H.L.L., HUANG Y., Han L., Chang R.C.C., Chan Y.S. and Lai S.W.C., Ketamine and selective activation of parvalbumin interneurons inhibit stress-induced dendritic spine elimination., Translational psychiatry . 2018, 8.

Ng N.Y., Tsui A.Y., Shum D.K.Y. and Chan Y.S., Derivation of oligodendrocytes precursor cells and pericytes from bone marrow-derived neurosphere cells, Abstracts of 14^th International Symposium on Healthy Aging. 2019, P59.

Peng Y.J., Zheng C.X., Chen X., Han L., Li M., Zhang G., Jiang H., Chan Y.S., Lau G.C. and He J., CCK released by entorhinal cortical neurons enables visuo-auditory associative learning, Gordon Research Conference – Neuroplasticity and Maladaptation of Sensory Systems. HK. June 3-8, 2018]. 2018.

Shen X., LIN L., LYU Q., ZHAO J., Chai A., Lai C.S., Chan Y.S. and Lai K.O., Impaired cognitive function and increased seizure susceptibility in mice depleted of the signalling protein TBC1D24, Abstracts of 14th International Symposium on Healthy Aging –Embrace the Golden Years : [HK. March 16-17, 2019]. 2019, P15.

Shum D.K.Y., KWAN P.Y., Ho S.N.S., Hau W.F., Tam K.W., Wu L.K., Ma C.W. and Chan Y.S., Dynamics of perineuronal net-associated plastic factors after sensory loss, Abstracts of 15^th Meeting of Asian-Pacific Society for Neurochemistry [Macau. Aug. 27-29, 2018]. 2018, 80.

Shum D.K.Y., KWAN P.Y., HAU W.F., Tam K.W., Wu L.K., Ma C.W. and Chan Y.S., Dynamics of perineuronal net-associated plastic factors after sensory loss, Abstracts of 15^th Meeting of Asian-Pacific Society for Neurochemistry, 80. [Macau. Aug. 27-29, 2018]. 2018, 80.

Shum D.K.Y., Tsui Y.P., Wu L.K., Tam K.W. and Chan Y.S., In vitro derivation of oligodendrocyte precursors from neural progenitors harbored in the adult bone marrow – implications for remyelination therapy, Abstracts of 11^th FENS Forum of Neuroscience, 312. [Berlin, Germany. July 7-11, 2018]. 2018.

Shum D.K.Y., Tsui Y.P., Wu L.K., Tam K.W. and Chan Y.S., In vitro derivation of oligodendrocyte precursors from neural progenitors harbored in the adult bone marrow--implications for remyelination therapy, 11th FENS Forum of Neuroscience . 2018.

Shum D.K.Y., Tam K.W. and Chan Y.S., Shifting macrophage polarisation to the anti-inflammatory state in the injured CNS, Soc. Neuroscience Abstract (USA). 2018, 213.28.

TAN Z.K.S., POON C.H., Chan Y.S. and Lim L.W., Deep brain stimulation of the medial prefrontal cortex disrupts consolidation of fear memories, 23rd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2018.

TAN Z.K.S., POON C.H., Chan Y.S. and Lim L.W., Deep brain stimulation of the medial prefrontal cortex disrupts consolidation of fear memories, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

TAN Z.K.S., Chan Y.S. and Lim L.W., Dsruption consolidation of fear memory through deep brain stimulation of the medial prefrontal cortex, Soc. Neuroscience Abstract (USA) [San Diego. Nov. 3-7, 2018]. 2018, 272.05.

TAN Z.K.S., Sheng V., Chan Y.S. and Lim L.W., Eternal sunshine of the neuromodulated mind: Altering fear memories through neuromodulation, Experimental Neurology. 2019, 314: 9-19.

Tam K.W., Shum D.K.Y. and Chan Y.S., Chondroitinase ABC induces macrophage polarized to M2 phenotype in central nervous system after injury, 11th FENS Forum of Neuroscience . 2018.

Tam K.W., Shum D.K.Y. and Chan Y.S., Chondroitinase ABC induces macrophage polarized to M2 phenotype in central nervous system after injury, Abstracts of 11^thFENS Forum of Neuroscience. 2018, 2122.

Tam K.W., Shum D.K.Y. and Chan Y.S., Chondroitinase ABC overcomes the axonal-restrictive CS at the sacr tissues and produces growth-promoting chondroitin sulphate-derived disaccharides, Abstracts of 14^th International Symposium on Healthy Aging. 2019, P8.

Tipoe G.L., Chan Y.S. and Lau C.S., Multiple Pathways for Biomedical Sciences at the School of Biomedical Sciences, The University of Hong Kong, 9th Asian Medical Education Association: Preparing Healthcare Learners for a Changing World. Hong Kong, 2018, 89.

Wong C.N., Shum D.K.Y. and Chan Y.S., Electrophysiological study of heparanase 2 protein in rat hippocampal neuronal cell, Abstracts of 14^th International Symposium on Healthy Aging. 2019, P11.

Wong M.C., Tam K.W., Kwok L.F., Chan Y.S., Shea G.K.H. and Shum D.K.Y., Genipin-treated chitosan nanofibers to assist post-traumatic axon regrowth and remyelination in the peripheral nervous system, Abstracts of 14^th International Symposium on Healthy Aging. 2019, P12.

Wong Y.C., Tam K.W., Cai S., Shum D.K.Y. and Chan Y.S., Towards autologous transplantation and remyelination therapy with use of human bone marrow stromal cell-derived Schwann cells, Abstracts of 14^th International Symposium on Healthy Aging. 2019, P62.

Wu L.K., Ho S.N., Hau W.F., Ma C.W., Shum D.K.Y. and Chan Y.S., Dynamics of perineuronal net-associated plastic factors after sensory loss, 11th FENS Forum of Neuroscience. 2018.

Wu L.K., Ho S.S.N., HAU W.F., Ma C.W., Shum D.K.Y. and Chan Y.S., Dynamics of perineuronal net-associated plastic factors after sensory loss, Abstracts of 11^th FENS Forum of Neuroscience. 2018, 1106.

YU W.S., Guan L., Shrestha S., Or Y., Lufkin T., Chan Y.S., Lin V.C.L. and Lim L.W., TTC9A deficiency induces social anxiety and estrogen-mediated alterations on amygdala-hippocampal neuroplasticity-related gene expression of mice, 23rd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2018.

Researcher : Chang RCC

Project Title:	Significance of molecular signaling for protein translation control in neurodegeneration of amyotrophic lateral sclerosis
Investigator(s):	Chang RCC
Department:	School of Biomedical Sciences
Source(s) of Funding:	Liu Po Shan/Dr Vincent Liu Endowment Fund for Motor Neuron diseases - General Award
Start Date:	03/2008

Project Title:	Elucidating the molecular defects associated with PTEN mutations in Autism Spectrum Disorders
Investigator(s):	Chang RCC
Department:	School of Biomedical Sciences
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	04/2015

Project Title:	Investigating oxyresveratrol as potential neuroprotective drug in experimental models of Parkinson’s disease
Investigator(s):	Chang RCC, Ng KM, Wang M, Ho YS
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2015
Completion Date:	12/2018

Project Title:	Investigation of drugs targeting mitochondrial dynamics and reactive oxygen species for Parkinson’s disease treatment using in vitro and in vivo imaging models
Investigator(s):	Chang RCC, Hung HLC
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2015
Completion Date:	12/2018

Project Title:	Establishment of pre-clinical platform and a novel 3D tissue visualisation protocol for therapeutic drug development of Lewy Body Dementias
Investigator(s):	Chang RCC
Department:	School of Biomedical Sciences
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	09/2016

Project Title:	Establishment of Pre-clinical Platform and a Novel 3D Tissue Visualisation Protocol for Therapeutic Drug Development of Lewy Body Dementias
Investigator(s):	Chang RCC
Department:	School of Biomedical Sciences
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	09/2016

Project Title:	Establishment of Pre-clinical Platform and a Novel 3D Tissue Visualisation Protocol for Therapeutic Drug Development of Lewy Body Dementias
Investigator(s):	Chang RCC
Department:	School of Biomedical Sciences
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	09/2016

Project Title:	Establishment of Pre-clinical Platform and a Novel 3D Tissue Visualisation Protocol for Therapeutic Drug Development of Lewy Body Dementias
Investigator(s):	Chang RCC, Gentleman SM
Department:	School of Biomedical Sciences
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	07/2017

Project Title:	Investigating the impact of periodontitis on neuroinflammation, neuropathology and neurodegeneration in Alzheimer's disease
Investigator(s):	Chang RCC, Khong PL, Leung WK
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	08/2017

Project Title:	Investigating the significant roles of PKR on systemic inflammation triggered neuroinflammation and cognitive dysfunctions
Investigator(s):	Chang RCC, Mak HKF, Wong GTC
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2018

Project Title:	Investigating alpha-synuclein and tau in frontal cortex and hippocampus of experimental Parkinson’s disease dementia (PDD)
Investigator(s):	Chang RCC, Ho YS
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2018

Project Title:	Investigating the effects of Lycium barbarum (wolfberry) on cognitive functions, neuropathology and neuroinflammation in experimental models of Parkinson's disease dementia
Investigator(s):	Chang RCC, Mak HKF
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	09/2018

Project Title:	The 14th International Conference on Alzheimer's and Parkinson's Diseases; SHORT-TERM RESISTANT EXERCISE AMELIORATES COGNITIVE DYSFUNCTION IN 9-MONTH 3XTG MICE
Investigator(s):	Chang RCC
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2019
Completion Date:	03/2019

Project Title:	Investigation of protein translation control regulated by endoplasmic reticulum stress or local protein translational control in experimental Alzheimer's disease
Investigator(s):	Chang RCC, Ho YS
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2019

List of Research Outputs

CHEN X., Kwan J.S.K., Ma A.C.H. and Chang R.C.C., Inhibition of melanogenesis alters autophagy in zebrafish (Danio rerio), The 14th International Symposium on Healthy Aging. 2019, 57.

CHEN X., Hasan K.M.M., Kwan J.S.K., Ma A.C.H. and Chang R.C.C., Systemic inflammation induces IL-1b-mediated microglia invasion in the Zebrafish brain, The 14th International Symposium on Healthy Aging. 2019, 58.

CHEN X., Hasan K.M.M., Kwan J.S.K., Ma A.C.H. and Chang R.C.C., Systemic inflammation induces IL-1β-mediated microglia invasion in the zebrafish brain, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

Chan H.H.L., Lam H.I., Choi K.Y., Li S.Z.C., Lakshmanan Y., Yu W.Y., Chang R.C.C., Lai J.S.M. and So K.F., Delay of cone degeneration in retinitis pigmentosa using a 12-month treatment with Lycium barbarum supplement, Journal of Ethnopharmacology. 2019, 236: 336-344.

Chang R.C.C., A short-term resistance exercise inhibits neuroinflammation and improves synaptic functions in 3xTg-AD mice, Gordon Research Conference: Cognitive dysfunctions in brain diseases, 2019. 2019.

Chang R.C.C., Editor-in-Chief, American Journal of Alzheimer's Disease and Other Dementias. 2019.

Chang R.C.C., Impact of silica nanoparticles-induced neurodegeneration and cognitive impairment, an example on the effect of environmental pollutant, Society for Neuroscience 2018, San Diego, USA. 2018.

Chang R.C.C., Potential of environmental pollutants as risk factors for developing cognitive dysfunction and Alzheimer’s disease, International Conference on the Prevention of Neurodegenerative Diseases: From Basic to Clinic, Shenzhen, CHINA. 2018.

Chang R.C.C., LIU Y., Chu M.T., Jin J. and Wong G.T.C., Short-term resistant exercise ameliorates cognitive dysfunction in 9-month 3xTg Mice, The 14th International Symposium on Alzheimer’s & Parkinson’s Diseases. 2019, #405.

Chang R.C.C., Systemic inflammation and neurodegeneration in Alzheimer’s disease, International Alzheimer’s disease Conference 2018, Science Park, Hong Kong. 2018.

Chen Z.X., Xu Q.Q., Shan C.S., Shi Y.H., Wang Y.S., Chang R.C.C. and Zheng G.T.C.Q., Borneol for regulating the permeability of the blood-brain-barrier in experimental ischemic stroke: preclinical evidence and possible mechanism, Oxidative Med. Cell. Longev.. 2019, 2019: 2936737.

Fan F., Zhang N.Q., SOERENSEN M.H. and Chang R.C.C., Unveiling mechanisms behind amyloid beta oligomer triggered autophagy, The 14th International Symposium on Healthy Aging. 2019, 64.

GONG Z., FANG C., You R., SHAO X., WEI X., Chang R.C.C. and Lin Y., Distinct Relaxation Timescales of Neurites Revealed by Rate-dependent Indentation, Relaxation and Micro-rheology Tests, Soft Matter. 2019, 15: 166-174.

HUANG C., Ng T.W., Irwin M.G., Hu X., Zhu S., Chang R.C.C. and Wong G.T.C., Differential effects of propofol and dexmedetomidine on neuroinflammation induced by systemic endotoxin lipopolysaccharides in adult mice, Australian and New Zealand College of Anaesthetists and Faculty of Pain Medicine ASM 2019.

HUANG C., Chu M.T., LIU Y., Chang R.C.C. and Wong G.T.C., Varenicline reduces DNA damage, tau mislocalization and post surgical cognitive impairment in aged mice, Neuropharmacology. 2018, 143: 217-227.

Ho Y.S., Lau C.F., Tang W.Y., Tian J.Y., Lee J.Q., Yung S.S.Y. and Chang R.C.C., Cognitive and pathological changes in an animal model of chronic kidney disease, The 14th International Symposium on Healthy Aging. 2019, 70.

LAI S.L.M., Lee K. and Chang R.C.C., Visualization of neural pathways in Parkinson’s disease by transparent brain and neural tracing, The 14th International Symposium on Healthy Aging. 2019, 64.

LIU K.L., Lim E.J., Ahmed I., Chang R.C.C., Pearce R.K.B. and Gentleman S.M., Revisiting the human cholinergic nucleus of the diagonal band of Broca, Neuropathol. Appl. Neurobiol.. 2018, 44: 647-662.

Lee K., Lai H.M. and Chang R.C.C., Development of a tissue clearing technique for Alzheimer’s disease research, International Alzheimer’s Disease Conference 2019 . 2019, 44.

Lee K., Lai H.M., SOERENSEN M.H., PANG C.C.C., Ho Y.S. and Chang R.C.C., Optimization of delipidation-based tissue clearing techniques for studying neuropathology in aging-associated neurodegenerative diseases, The 14th International Symposium on Healthy Aging. 2019, 62.

NG H.L.L., HUANG Y., Han L., Chang R.C.C., Chan Y.S. and Lai S.W.C., Ketamine and selective activation of parvalbumin interneurons inhibit stress-induced dendritic spine elimination., Translational psychiatry . 2018, 8.

PANG C.C.C., Lee K., Luk K.C., Lee V.M., Trojanowski J.Q., Noble W. and Chang R.C.C., Investigating spreading of -synuclein and the consequences on cognitive dysfunction and neuropathology in experimental Parkinson’s disease models., The 14th International Symposium on Alzheimer’s & Parkinson’s Diseases. 2019, #462.

SHAH A.N., Han P., Legido-Quigley C.S. and Chang R.C.C., Investigating novel changes of metabolites in the plasma and mid-brain in experimental Parkinson’s disease using 6-hydroxydopamine as toxin model, The 14th International Symposium on Healthy Aging. 2019, 61.

SHAH A.N., Han P., Wong M.Y., Chang R.C.C. and Legido-Quigley C., Palmitate and stearate are increased in the plasma in a 6-OHDA model of Parkinson’s disease, Metabolities. 2019, 9: pii: E31.

SHAO X., You R., HUI T.H., FANG C., GONG Z., YAN Z., Chang R.C.C., Shenoy V.B. and Lin Y., Tension- and Adhesion-Regulated Retraction of Injured Axons, Biophysical Journal. 2019, 117: 193-202.

SOERENSEN M.H., Fan F.C.P. and Chang R.C.C., Investigation of the cellular effects of alpha-synuclein preformed fibrils in primary cultures of hippocampal neurons, The 14th International Symposium on Healthy Aging. 2019, 62.

WANG P.H., Zhang S., Leung W.K., Ho Y.S. and Chang R.C.C., Investigating the impact of periodontitis on neuroinflammation of Alzheimer’s disease, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

Wong P.Y., Lee K. and Chang R.C.C., Protocol for generating transparent adult zebrafish for investigating aging-associated neurodegenerative diseases, The 14th International Symposium on Healthy Aging. 2019, 62.

YOU R., LIU Y. and Chang R.C.C., A behavioral test battery for the repeated assessment of motor skills, mood, and cognition in mice, J. Vis. Exp.. 2019.

YOU R., Ho Y.S., Hung H.L.C., LIU Y., HUANG C., Chan H.N., Ho S.L., Lui S.Y., Li H.W. and Chang R.C.C., Silica nanoparticles induce neurodegeneration-like changes in behaviour, neuropathology, and affect synapse through MAPK activation, Particle Fibre Toxicology. 2018, 15: 28.

Yang Z., Yan T., Li S., Wei M., Qi H., Shen B., Chang R.C.C., Le W. and Piao F., Altered expression levels of microRNA-132 and Nurr1 in peripheral blood of Parkinson’s disease: a potential disease biomarker, ACS Chem. Neurosci.. 2019, 10: 2243-2249.

Researcher : Chaudhary V

List of Research Outputs

Researcher : Cheah KSE

Project Title:	Defining the role of the transcription factor Sox9 in skeletal development by tissue-specific gene inactivation
Investigator(s):	Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	UK/Hong Kong Joint Research Scheme
Start Date:	02/1998

Project Title:	4th Pan-Pacific Connective Tissues Societies Symposium Abnormal Regulation of Cartilage and Bone Growth in Transgenic Mice Expressing a Collagen X SMCD Mution
Investigator(s):	Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/1999

Project Title:	Human Genome Meeting 2001 Genomic Analysis of the Mutant Locus in the Novel Transgenic Mouse Mutant, Yellow Submarine (ysb)
Investigator(s):	Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2001

Project Title:	67th Cold Spring Harbor Symposium on Quantitative Biology - The Cardiovascular System An Essential Role for Type IIA Procollagen in Heart Development
Investigator(s):	Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2002

Project Title:	1st Annual Meeting of the American Society for Matrix Biology Type IIA Procollagen is Essential for Proper Heart Development
Investigator(s):	Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2002

Project Title:	The Gordon Research Conference on Cartilage Biology and Pathology Chondrocytes Survive ER Stress Caused by Unfolded Proteins and Differentiation is Re-programmed
Investigator(s):	Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	06/2005

Project Title:	11th Human Genome Meeting Procollagen IIA Facilitates BMP Signaling in Heart Development
Investigator(s):	Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2006

Project Title:	Cold Spring Harbor Laboratory Meeting on Mouse Molecular Genetics Insight into the Molecular Pathogenesis of Campomelic Dysplasia Received By A Conditional SOX9 Mutant Mouse Model
Investigator(s):	Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	08/2006

Project Title:	Role of Sox2 in the stemness of dermal precursors
Investigator(s):	Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2010

Project Title:	Functional Analyses of How Genomic Variation Affects Personal Risk for Degenerative Skeletal Disorders
Investigator(s):	Cheah KSE, Chan BP, Chan D, Cheung KMC, Jin D, Lian Q, Luk KDK, Sham PC, Zhang MQ, Cherny SS, Huang J, Ng RK, Samartzis D, Song Y, Wang JJ
Department:	School of Biomedical Sciences
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	01/2013
Completion Date:	12/2019

Project Title:	Development and Reproduction
Investigator(s):	Cheah KSE, Ng EHY, Wu EX
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	06/2013

Project Title:	Craniofacial Morphogenesis & Tissue Regeneration; Transcriptional control of sensory progenitor specification in the inner ear
Investigator(s):	Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2014

Project Title:	Mechanisms controlling determination of sensory versus non-sensory fate in inner ear development
Investigator(s):	Cheah KSE, Wong YME, Jin D
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2014
Completion Date:	10/2018

Project Title:	Global Spine Congress 2015; The changing RNAome of the developing nucleus pulposus of the intervertebral disc - implications for Intervertebral Disc Disease
Investigator(s):	Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2015

Project Title:	Gordon Research Conference on Bones and Teeth; Dissecting the transition from hypertrophic chondrocyte to osteoblast in skeletal development and growth
Investigator(s):	Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	02/2016

Project Title:	Sox9 control of neuromesodermal progenitors
Investigator(s):	Cheah KSE, Cheung MCH, Lian Q
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	09/2017

Project Title:	Molecular control of hypertrophic chondrocyte cell fate and lineage extension
Investigator(s):	Cheah KSE, Chan D, Zhou Z
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2018

Project Title:	Analyses of progenitors and differentiation trajectories in the nucleus pulposus: the role of Notch signaling
Investigator(s):	Cheah KSE, Chan D
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research for Resubmission of GRF/ECS Proposals
Start Date:	07/2018

Project Title:	Identification of Sox2 otic enhancers and their utility for restoring hearing and vestibular function
Investigator(s):	Cheah KSE, Lui VCH
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	09/2018

Project Title:	Role(s) of TAGLN expressing cells in intervertebral disc development, homeostasis and degeneration
Investigator(s):	Cheah KSE, Chan D, Leung VYL
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2019

Project Title:	Gordon Research Conference "Neural Crest and Cranial Placodes; Dual modes of cooperative repression by SOX9 and SOX10 and SOX9 transactivation of genes essential for inner ear fluid homeostasis maintain hearing
Investigator(s):	Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2019

Project Title:	METHOD FOR PREVENTING OR MODULATING FIBROSIS AND FIBROTIC RESPONSE ASSOCIATED WITH THE INTEGRATED STRESS RESPONSE
Investigator(s):	Cheah KSE, Ng IOL
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Translational and Applied Research
Start Date:	06/2019

Project Title:	Systems analyses of regulatory networks for directing cell fate and lineage development of constituent cells of the intervertebral disc (CRF)
Investigator(s):	Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Funding for Strategic Interdisciplinary Research Scheme
Start Date:	06/2019

List of Research Outputs

Ali S.A., Niu B., Cheah K.S.E. and Alman B., Unique and overlapping GLI1 and GLI2 transcriptional targets in neoplastic chondrocytes, PLOS ONE. 2019, 14: e0211333.

Cheah K.S.E., Changing cell population heterogeneity in the nucleus pulposus in intervertebral disc degeneration, 2019 Annual Meeting of Korean Society for Cartilage and Osteoarthritis, February 15, 2019, Seoul, Korea.. 2019.

Cheah K.S.E., Chondrocyte lineage plasticity in development and disease, Research seminar, Center for Human Genetics and Genomics, New York University, March 13, 2019. 2019.

Cheah K.S.E., Szeto Y.Y., Chu D.K.H., Au Y.K., Huang Y.H., Wynn S.L., Mak A.C.Y., Chan Y.S., Chan W.Y., Jauch R., Fritzsch B., Lovell-Badge R.H. and Sham M.H., Dual modes of cooperative repression by SOX9 and SOX10 and SOX9 transactivation of genes essential for inner ear fluid homeostasis maintain hearing., Gordon Research Conference on Neural Crest and Cranial Placodes. 2019.

Cheah K.S.E., Editorial Review Board, Journal of Orthopaedic Research. 2019.

Cheah K.S.E., Insights into the cellular basis of intervertebral disc degeneration revealed by single cell analyses and lineage tracing” The Croucher Foundation – Advanced Study Institute on Genetic Variation and Genome Architecture in Development, Health and Disease. December 11 & 13, 2019 in Hong Kong. 2018.

Cheah K.S.E., Guo S., Chen P., Au Y.K., Niu B., Wu R., Cheung K.M.C., Cheung J.P.Y., Sakai D., Chan D., Zhang M.Q., Richardson S. and Hoyland J., Insights into the cellular basis of intervertebral disc disease gained from the transcriptomes of single cells., Gordon Research Conference on Cartilage Biology and Pathology.. 2019.

Cheah K.S.E., Insights into the cellular basis of intervertebral disc disease gained from the transcriptomes of single cells, 2019 Annual meeting of Korean Society for Cartilage and Osteoarthritis. Feb 15, 2019.

Cheah K.S.E., Insights into the cellular basis of intervertebral disc disease gained from the transcriptomes of single cells, Gordon Research Conference on Cartilage Biology and Pathology. March 17 – 22, 2019, Hotel Galvez in Galveston, TX, USA.. 2019.

Cheah K.S.E., Member, Conference Evaluation Committee, 2019-2025., Gordon Research Conferences Board of Trustees . 2019.

Cheah K.S.E., OA pathogenesis for beginners: lineage tracing in skeletal pathophysiology, Osteoarthritis Research Society International (OARSI) meeting, May 2-5, 2019, Toronto, Canada.. 2019.

Cheah K.S.E., Preventing and Alleviating Chondrodysplasia by Inhibiting Integrated Stress Response Pathway, The 11th Asian and Pan-pacific Connective Tissue Society Symposium & the 3th National Conference of CSMB, November 16-20, 2018, Hangzhou, China. 2018.

Cheah K.S.E., Reviewing Editor, eLife. 2019.

Cheah K.S.E., Senior Editor, eLIFE. 2019.

Cheah K.S.E., Skeletal lineage plasticity in development and disease, Orthopaedic Research Society 2019 Annual Meeting February 2-5, 2019, Austin, Texas, USA. 2019.

Cheah K.S.E., The integrated stress response in skeletal development and disease, International Society of Differentiation Meeting ComBio 2018, September 22-27, 2018 in International Convention Centre, Sydney. 2018.

Cheah K.S.E., The integrated stress response in skeletal development and disease, International Society of Differentiation Meeting ComBio 2018, Sydney, Australia, Sep 22-27, 2018.

GUO S. and Cheah K.S.E., Poster Presentation Prize “Single cell analyses of human intervertebral discs implicate HOPX as a regulator of homeostasis”, Research Day, School of Biomedical Sciences, the University of Hong Kong, December 14, 2018.. 2018.

GUO S., Chen P., Tan Z., Au Y.K., Niu B., Tam V., Cheung K.M.C., Cheung J.P.Y., Chan D., Sham P.C., Sakai D., Rickardson S., Hoyland J. and Cheah K.S.E., Single cell analyses of human intervertebral discs implicate HOPX as a regulator of homeostasis, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

LEE C.M., Lau K.S.A., TANG H.L., Wang M., Mok T.Y., CHUNG M.F., Yan W., Shum H.C., Cheah K.S.E., Chan G.C.F., So H.K.H., Wong K.K.Y. and Tsia K.K.M., Multi‐ATOM: Ultrahigh‐throughput single‐cell quantitative phase imaging with subcellular resolution, Journal of Biophotonics. 2019, e201800479.

LEE C.M., Cheah K.S.E., Chan G.C.F., So H.K.H., Wong K.K.Y. and Tsia K.K.M., Quantitative phase imaging flow cytometry for ultra-large-scale single-cell biophysical phenotyping, Cytometry Part A. 2019, 95.

TAM K.T., Leung K.K.H., Chen P., Kwong W.H., Pelling A., Pelling A., Lovell-Badge R.H. and Cheah K.S.E., From high to low: SOX2 dosage control of otic prosensory fate revealed by single cell transcriptome analyses, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

TAM K.T., Chen P., Leung K.K.H., Kwong M.W.H., Pelling A., Fritzsch B., Lovell-Badge R.H. and Cheah K.S.E., SOX2 dosage dependent control of otic cell identity revealed by single-cell transcriptome analyses, Japanese Society of Developmental Biologists Conference. 2019.

Tang S.M., Li P., Lai P.L., Fu A., Lau C.S.T., So M.T., Lui N.C., Li Z., Zhuang X., Yu M., Liu X., Ngo N., Miao X., Zhang X., Yi B., Tang S., Sun X., Zhang F., Liu H., Liu Q., Wang H., Huang L., Dong X., Tou J., Cheah K.S.E., Yang W., Yuan Z., Yip K., Sham P.C., Tam P.K.H., Garcia-Barcelo M.M. and Ngan E.S.W., Identification of genes associated with Hirschsprung Disease, based on whole-genome sequence analysis, and potential effects on enteric nervous system development, Gastroenterology. 2018, 155(6): 1908-1922.

Wang C., Tan Z., Niu B., Tsang K.Y., Tai C.P., Chan W.C.W., Lo R.L.K., Leung K.K.H., Dung W.F., Itoh N., Zhang M.Q., Chan D. and Cheah K.S.E., Inhibiting the integrated stress response pathway prevents aberrant chondrocyte differentiation thereby alleviating chondrodysplasia, eLife. 2018, 7: e37673.

Yip K.H.R., Chan D. and Cheah K.S.E., Mechanistic insights into skeletal development gained from genetic disorders, Curr Top Dev Biol. 2019, 133: 343-385.

Zhou X., Cheung C.L., Karasugi T., Karppinen J., Samartzis D., Hsu Y.H., Mak S.H.T., Song Y., Chiba K., Kawaguchi Y., LI Y., Chan D., Cheung K.M.C., Ikegawa S., Cheah K.S.E. and Sham P.C., Trans-ethnic polygenic analysis supports genetic overlap of lumbar disc degeneration with height, body mass index, and bone mineral density., Frontiers in Genetics. 2018.

Researcher : Chen J

Project Title:	Investigating the molecular mechanisms how ΔF508 mutation delays phosphorylation-dependent CFTR activation
Investigator(s):	Chen J
Department:	School of Biomedical Sciences
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2014

Project Title:	Investigating the mechanisms how Pseudomonas aeruginosa affects the function of airway epithelia
Investigator(s):	Chen J, Li NF, Wong PF
Department:	School of Biomedical Sciences
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2016

Project Title:	Regional function around the F508 residue in protein processing and channel gating of CFTR
Investigator(s):	Chen J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2016

Project Title:	Investigating the molecular mechanisms how Pseudomonas aeruginosa infection enhances the permeability of airway epithelia.
Investigator(s):	Chen J, Yan A
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	03/2017

List of Research Outputs

Researcher : Chen P

List of Research Outputs

Cheah K.S.E., Guo S., Chen P., Au Y.K., Niu B., Wu R., Cheung K.M.C., Cheung J.P.Y., Sakai D., Chan D., Zhang M.Q., Richardson S. and Hoyland J., Insights into the cellular basis of intervertebral disc disease gained from the transcriptomes of single cells., Gordon Research Conference on Cartilage Biology and Pathology.. 2019.

GUO S., Chen P., Tan Z., Au Y.K., Niu B., Tam V., Cheung K.M.C., Cheung J.P.Y., Chan D., Sham P.C., Sakai D., Rickardson S., Hoyland J. and Cheah K.S.E., Single cell analyses of human intervertebral discs implicate HOPX as a regulator of homeostasis, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

JIANG D., XIONG G., FENG H., ZHANG Z., Chen P., Yan B., CHEN L., Kesavamoorthy G., MA C.Y., Li C., HAN S., Zhang Y., Liao C., Lee T.L., Tse H.F., Fu Q.L., Chiu K. and Lian Q., Donation of mitochondria by iPSC-derived mesenchymal stem cells protects retinal ganglion cells against mitochondrial complex I defect-induced degeneration, Theranostics. Australia, Ivyspring International Publisher, 2019, 2019, Vol. 9, Issue 8: 2395-2410.

Jiang D., Xiong G., Feng H., ZHANG Z., Chen P., Yan B., Chen P., Kesavamoorthy G., Ma C.Y., Li C., Han S., Zhang Y., Liao C., Lee T.L., Tse H.F., Fu Q., Chiu K. and Lian Q., Donation of mitochondria by iPSC-derived mesenchymal stem cells protects retinal ganglion cells against mitochondrial complex I defect-induced degeneration, Theranostics. 2019, 9(8): 2395-2410.

TAM K.T., Leung K.K.H., Chen P., Kwong W.H., Pelling A., Pelling A., Lovell-Badge R.H. and Cheah K.S.E., From high to low: SOX2 dosage control of otic prosensory fate revealed by single cell transcriptome analyses, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

TAM K.T., Chen P., Leung K.K.H., Kwong M.W.H., Pelling A., Fritzsch B., Lovell-Badge R.H. and Cheah K.S.E., SOX2 dosage dependent control of otic cell identity revealed by single-cell transcriptome analyses, Japanese Society of Developmental Biologists Conference. 2019.

Researcher : Cheng Y

Project Title:	Identification and characterization of C11ORF86, a novel CREBH target gene implicated in hypertriglyceridemia
Investigator(s):	Cheng Y, Tipoe GL, Chan CP, Ye Z
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	09/2018

List of Research Outputs

Wang F., Ye Z., Deng J., Siu K.L., Gao W., Chaudhary V., Cheng Y., Fung S.Y., Yuen K.S., Ho T.H., Chan C.P., Zhang Y., Kok K.H., Yang W., Chan C.P. and Jin D., Inhibition of AIM2 inflammasome activation by a novel transcript isoform of IFI16. , EMBO reports. 2018.

Researcher : Cheung A

Project Title:	Identification of miR-29c/FBXO31 as a key regulatory mechanism in esophageal cancer chemoresistance-functional validation and implication for therapy
Investigator(s):	Cheung A, Li B
Department:	School of Biomedical Sciences
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2015

Project Title:	Role and mechanism of serglycin in promoting esophageal cancer invasion and metastasis
Investigator(s):	Cheung A, Chan KW, Tsao GSW, Law SYK
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2016

Project Title:	Significance of miR-338-5p in modulating PAK4 signaling and metastasis of esophageal cancer
Investigator(s):	Cheung A, Tsao GSW
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2018

List of Research Outputs

CUI D., Han L., ZHU Y., YAN D., Tsao G.S.W. and Cheung A., Role and mechanism of miR-338-5p in regulating metastasis of esophageal cancer, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

Li B., Hong P., Zheng C.C., Dai W., Chen W.Y., Yang Q.S., Han L., Tsao G.S.W., Chan K.T., Lee N.P.Y., Law S.K., Xu L.Y., Li E.M., Chan K.W., Qin Y.R., Guan X., Lung M.L., He Q.Y., Xu W.W. and Cheung A., Identification of miR-29c and its Target FBXO31 as a Key Regulatory Mechanism in Esophageal Cancer Chemoresistance: Functional Validation and Clinical Significance., Theranostics 2019. 2019, 9(6):1599-1613.

Li B., Hong P., Zheng C.-.C., Dai W., Chen W.-.Y., Yang Q.-.S., HAN L., Tsao G.S.W., Chan K.T., Lee N.P.Y., Law S.Y.K., Xu L.Y., Li E.M., Chan K.W., Qin Y.R., Guan X., Lung M.L., He Q.-.Y., Xu W. and Cheung A., Identification of miR-29c and its Target FBXO31 as a Key Regulatory Mechanism in Esophageal Cancer Chemoresistance: Functional Validation and Clinical Significance, Theranostics. 2019, 9: 1599-1613.

Lin W., Yip Y.L., Jia L.J., Deng W., Zheng H., Dai W., Ko J.M.Y., Lo K.W., Chung G.T.Y., Yip K.Y., Lee S.D., Kwan J.S.H., Zhang J., Liu T.F., Chan Y.W., Kwong D.L.W., Lee V.H.F., Nicholls J.M., Busson P., Liu X.F., Chiang A.K.S., Hui K.F., Kwok H., Cheung S.T., Cheung Y.C., Chan C.K., Li B., Cheung A., Hau P.M., Zhou Y., Tsang C.M., Middeldorp J., Chen H., Lung M.L. and Tsao G.S.W., Establishment and characterization of new tumor xenografts and cancer cell lines from EBV-positive nasopharyngeal carcinoma, Nature Communications. 2018, 7; 9(1): 4663.

Xu W.W., Li B., Zhao J.F., Yang J.G., Li J.Q., Tsao G.S.W., He Q.Y. and Cheung A., IGF2 induces CD133 expression in esophageal cancer cells to promote cancer stemness, Cancer Letters. 2018, 425: 88-100.

ZHU Y., Li B., Xu W., Lam A.K.Y., Lee N.P.Y., Law S.Y.K. and Cheung A., Role of serglycin in promoting esophageal cancer invasion and metastasis, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

ZHU Y. and Cheung A., Serglycin promotes migration and invasion of esophageal cancer cells, 2019 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2019.

Zhang J., Jia L.J., Liu T.E.N.G.F.E.I., Yip Y.L., Tang W.C., Lin W., Deng W., Lo K.W.O.K. .W.A.I., You C., Lung M.L., Lung H.L., Tsao G.S.W., Cheung A. and Tsang C.M., mTORC2-mediated PDHE1α nuclear translocation links EBV-LMP1 reprogrammed glucose metabolism to cancer metastasis in nasopharyngeal carcinoma., Oncogene. 2019, 38(24): 4669-4684.

Researcher : Cheung KH

Project Title:	Role of TMEM16A in the formation of epididymal microenvironment
Investigator(s):	Cheung KH
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2015

Project Title:	Role of presenilin-1 in pancreatic beta-cell insulin secretion
Investigator(s):	Cheung KH
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2016

Researcher : Cheung MCH

Project Title:	Elucidating the role of Sox9 in cell fate acquisition of neural crest progenitors in the dorsal root ganglia
Investigator(s):	Cheung MCH, Sham MH, Lui VCH, Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2015
Completion Date:	10/2018

Project Title:	Elucidating the therapeutic potential of neural stem cells with genetic manipulation of Sox9 expression following spinal cord injury
Investigator(s):	Cheung MCH, Wu W, Cheah KSE
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2016

Project Title:	Elucidating the role of Deleted in Liver Cancer-1 (DLC1) in melanoma development and therapy
Investigator(s):	Cheung MCH, Guan X
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2017
Completion Date:	09/2018

Project Title:	Elucidating the role of DEPDC1B in melanoma development and therapy
Investigator(s):	Cheung MCH, Guan X
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2017

Project Title:	SOX9 is a dose-dependent oncogenic fate determinant in melanoma
Investigator(s):	Cheung MCH
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2018
Completion Date:	09/2019

Project Title:	A nuclear form of RhoGAP Deleted in Liver Cancer 1 (DLC1) regulates neural crest specification in a RhoGAP-independent manner.
Investigator(s):	Cheung MCH
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2019

Project Title:	Gordon Research Conference: Neural Crest and Cranial placodes; Development, Disease and Evolution: Interdisciplinary Approaches to the Neural Crest and Cranial Placodes; Recruitment of distinct subcellular complexes by RhoGAP DLC1 in governing cranial neural crest specification and epithelial-to-mesenchymal transition
Investigator(s):	Cheung MCH
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2019
Completion Date:	04/2019

List of Research Outputs

Cheung M.C.H., Recruitment of distinct subcellular complexes by RhoGAP DLC1 in governing cranial neural crest specification and epithelial-to-mesenchymal transition, Gordon Research Conference on Neural Crest and Cranial Placodes. 2019.

Liu A.J., Hong J.L., Cheung M.P.L. and Cheung M.C.H., SOX10 determines glial fate choice in the dorsal root ganglia through destabilisation of neurogenic 2, 6th Macau Symposium on Biomedical Sciences. 2019.

YANG X., HU F., Cheung M.P.L., LUNG H.L. and Cheung M.C.H., DLC1 promotes melanoma invasion through activation of MMP9 by interaction with FOXK1, 2019 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2019.

YANG X., Cheung M.P.L., Lung L.H. and Cheung M.C.H., DLC1 promotes melanoma progression by interaction with FOXK1, 23rd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2018.

YANG X., LIANG R., Liu C.X., Liu A.J., Cheung M.P.L., Liu X.L., Man O.Y., Guan X., Lung H.L. and Cheung M.C.H., SOX9 is a dose-dependent metastatic fate determinant in melanoma, Journal of Experimental & Clinical Cancer Research. 2019, 38.

Researcher : Cheung MPL

List of Research Outputs

Liu A.J., Hong J.L., Cheung M.P.L. and Cheung M.C.H., SOX10 determines glial fate choice in the dorsal root ganglia through destabilisation of neurogenic 2, 6th Macau Symposium on Biomedical Sciences. 2019.

YANG X., HU F., Cheung M.P.L., LUNG H.L. and Cheung M.C.H., DLC1 promotes melanoma invasion through activation of MMP9 by interaction with FOXK1, 2019 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2019.

YANG X., Cheung M.P.L., Lung L.H. and Cheung M.C.H., DLC1 promotes melanoma progression by interaction with FOXK1, 23rd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2018.

YANG X., LIANG R., Liu C.X., Liu A.J., Cheung M.P.L., Liu X.L., Man O.Y., Guan X., Lung H.L. and Cheung M.C.H., SOX9 is a dose-dependent metastatic fate determinant in melanoma, Journal of Experimental & Clinical Cancer Research. 2019, 38.

Researcher : Cheung PHH

List of Research Outputs

CHEUNG P.H.H. and Jin D., Influenza A virus PB1-F2 protein suppresses IL-1β production from human macrophages by enhancing MAVS degradation, American Society for Virology Travel Award. 2018.

Fung S.Y., Cheung P.H.H., Chan C.P. and Jin D., Perturbation of innate DNA sensing by human RNA viruses., The 7th Cross Straight Immunology Conference. 2018.

Researcher : Cheung WTL

Project Title:	Targeting PIK3R1 copy number loss in ovarian cancer
Investigator(s):	Cheung WTL
Department:	School of Biomedical Sciences
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	01/2017

Project Title:	Characterization of PIK3R1 nSH2 domain mutations in cancer
Investigator(s):	Cheung WTL
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2017
Completion Date:	03/2019

Project Title:	Exploiting synthetic lethal interactions with EGFR inhibitor for translation to cancer therapies
Investigator(s):	Cheung WTL
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Translational and Applied Research
Start Date:	04/2017

Project Title:	Development of novel nanomedicine to enhance cancer chemotherapy response
Investigator(s):	Cheung WTL
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Translational and Applied Research
Start Date:	06/2018

Project Title:	Functional characterization of AKTIP in breast cancer
Investigator(s):	Cheung WTL
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2018

Project Title:	Elucidation of a novel p85β-AXL regulatory loop and associated signaling in ovarian cancer
Investigator(s):	Cheung WTL
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2019

Project Title:	American Association for Cancer Research (AACR) Annual Meeting 2019; p85α alters Gab2 phosphorylation profile in ovarian cancer
Investigator(s):	Cheung WTL
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2019
Completion Date:	04/2019

Project Title:	Defining the transcriptional network for oncogenesis in PIK3R2-amplified tumors
Investigator(s):	Cheung WTL
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2019

List of Research Outputs

Cheung W.T.L., Editorial Board Member, Current Cancer Drug Targets. 2019.

Cheung W.T.L., Editorial Board, Chinese Clinical Oncology. 2019.

LI X., Ng A.S., Mak C.Y., Zhou Y., Cheung A.N.Y. and Cheung W.T.L., Characterization of PIK3R1 driver aberrations reveals novel therapeutic responses in gynecological cancers., 14th International Symposium on Healthy Aging “Embrace the Golden Years”. 2019.

LI X., Mak C.Y., Zhou Y., Cheung A.N.Y. and Cheung W.T.L., Decreased PIK3R1 expression activates AKT and STAT3 in ovarian cancer, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

LI X., Mak C.Y., Zhou Y., Chao W., Wong E.S.Y., Sharma R., Lu Y., Cheung A.N.Y., Mills G.B. and Cheung W.T.L., Deregulated Gab2 phosphorylation mediates aberrant AKT and STAT3 signaling upon PIK3R1 loss in ovarian cancer, Nature Communications. 2019, 10: 716.

LI X., Mak C.Y., Cheung A.N.Y., Mills G.B. and Cheung W.T.L., p85α alters Gab2 phosphorylation profile in ovarian cancer, American Association of Cancer Research (AACR) Annual Meeting 2019.

RAO L., Mak C.Y., Fung C.Y., Zhou Y. and Cheung W.T.L., Therapeutic Implication of PIK3R2 Amplification in Ovarian Cancer, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

RAO L., Mak C.Y., Fung C.C., Zhou Y. and Cheung W.T.L., Therapeutic implication of PIK3R2 amplification in ovarian cancer, 14th International Symposium on Healthy Aging “Embrace the Golden Years”. 2019.

RAO L., Mak C.Y., Fung C.C.Y., Zhou Y. and Cheung W.T.L., Therapeutic implication of PIK3R2 amplification in ovarian cancer, 23rd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2018.

Researcher : Cheung YC

List of Research Outputs

Lin W., Yip Y.L., Jia L.J., Deng W., Zheng H., Dai W., Ko J.M.Y., Lo K.W., Chung G.T.Y., Yip K.Y., Lee S.D., Kwan J.S.H., Zhang J., Liu T.F., Chan Y.W., Kwong D.L.W., Lee V.H.F., Nicholls J.M., Busson P., Liu X.F., Chiang A.K.S., Hui K.F., Kwok H., Cheung S.T., Cheung Y.C., Chan C.K., Li B., Cheung A., Hau P.M., Zhou Y., Tsang C.M., Middeldorp J., Chen H., Lung M.L. and Tsao G.S.W., Establishment and characterization of new tumor xenografts and cancer cell lines from EBV-positive nasopharyngeal carcinoma, Nature Communications. 2018, 7; 9(1): 4663.

Researcher : Cheung YW

List of Research Outputs

Cheung Y.W., Dirkzwager R.M., Wong W.C., Cardoso J., D'Arc Neves Costa J. and Tanner J.A., Aptamer-mediated Plasmodium-specific diagnosis of malaria, Biochimie. 2018, 145: 131-136.

Cheung Y.W., Röthlisberger P., Mechaly A., Wong A.C.C., Weber P., Levi-Acobas F., Haouz A., Savage P., Hollenstein M. and Tanner J.A., Selection and structural analysis of cubane-modified aptamers for targeting Plasmodium vivax lactate dehydrogenase, Aptamers 2019, 6th Oxford Symposium on Aptamers, Oxford University, United Kingdom. 2019.

FRASER L.A., Cheung Y.W., Kinghorn A.B., Guo W., SHIU C.C., JINATA C., LONG F., BHUYAN S.K., Nan L., Shum H.C. and Tanner J.A., Microfluidic Technology for Nucleic Acid Aptamer Evolution and Application, Advanced Biosystems. 2019, 3: 1900012.

Figueroa-Miranda G., LO Y., Cheung Y.W., Tanner J.A., Offenhausser A. and Mayer D., Improved aptasensor performance for the detection of PfLDH malaria biomarkers in human serum, Aptamers 2019, 6th Oxford Symposium on Aptamers, Oxford University, United Kingdom. 2019.

Fraser L.A., Kinghorn A.B., Dirkzwager R.M., Liang S., Cheung Y.W., Lim B., Shiu C.C., Tang S.L.M., Andrew D., Manitta J., Richards J.S. and Tanner J.A., A portable microfluidic Aptamer-Tethered Enzyme Capture (APTEC) biosensor for malaria diagnosis, Biosensors and Bioelectronics. 2018, 100(Supplement C): 591-596.

LIU M., Cheung Y.W., Yu Y.Y., Choi N.T.V. and Tanner J.A., Development of Nucleic Acid Aptamer-functionalized Regenerative Medicine for Regenerative Applications, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

LIU M., YU Y., Cheung Y.W., Choi N.T.V. and Tanner J.A., Development of aptamer inhibitors against ADAMTS-5 for osteoarthritis disease, Aptamers 2019, 6th Oxford Symposium on Aptamers, Oxford University, United Kingdom. 2019.

Miranda G.F., Feng L., SHIU C.C., DIRKZWAGER R.M., Cheung Y.W. and Tanner J.A., Aptamer-based electrochemical biosensor for highly sensitive and selective malaria detection with adjustable dynamic response range and reusability, 11th International Workshop on Impedance Spectroscopy, Chemnitz, Germany. 2018.

SHIU C.C., Kinghorn A.B., Sakai Y., Cheung Y.W., Heddle J.G. and Tanner J.A., Three S’s for aptamer-mediated control of DNA nanostructure dynamics: shape, self-complementarity and spatial flexibility, Chembiochem. 2018, 19(18): 1900.

Tang S.L.M., Shiu C.C., Godonoga M., Cheung Y.W., Liang S., Dirkzwager R.M., Kinghorn A.B., Fraser L.A., Heddle J.G. and Tanner J.A., An aptamer-enabled DNA nanobox for protein sensing, Nanomedicine: Nanotechnology, Biology and Medicine. 2018, 14(4): 1161-1168.

Tanner J.A., Kinghorn A.B. and Cheung Y.W., Co-Editor, In: Julian Alexander Tanner, Andrew Brian Kinghorn and Yee-Wai Cheung, Aptamers. MDPI Books, 2018.

Researcher : Ching YP

Project Title:	Roles of p21-activated protein kinase (Pak) 1 in the pathogenesis of liver cancer
Investigator(s):	Ching YP, Ng IOL, Jin D, Yau TO
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2006

Project Title:	A study of the role of CDK5RAP3 in neuronal cell differentiation
Investigator(s):	Ching YP, Chang RCC
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2015
Completion Date:	12/2018

Project Title:	Functional characterization of the roles of Polo-like kinase 4, Plk4 in hepatocarcinogenesis
Investigator(s):	Ching YP
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016

Project Title:	A study of the role of p21-activated kinase 4 (PAK4) in chromosome instability
Investigator(s):	Ching YP
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2017
Completion Date:	03/2019

Project Title:	A study of the regulation of TAX1 binding protein 2 by p21-activated protein kinase 4 in liver cancer metastasis
Investigator(s):	Ching YP
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2017

Project Title:	Characterization of the role of liver cancer stem cell marker, CD133 in promoting chromosome instability in hepatocarcinogenesis
Investigator(s):	Ching YP, Ma SKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2018

Project Title:	Molecular mechanisms of Pumilio-Regulated Chromosomal Instability in Hepatocellular Carcinoma
Investigator(s):	Ching YP
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2018

Project Title:	Development of a P-21 activated protein kinase 4 specific inhibitory peptide as a novel hepatocellular carcinoma therapeutic agent
Investigator(s):	Ching YP
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Translational and Applied Research
Start Date:	04/2019

Project Title:	Regulation of a putative tumor suppressor, TAX1 binding protein 2 (TAX1BP2) by a centrosomal salt-inducible kinase
Investigator(s):	Ching YP
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2019

List of Research Outputs

CHAN L.H., Zhou L., Ng K.Y., Wong T.L., Lee T.K., Sharma R., LOONG H.C., Ching Y.P., Yuan Y.F., Xie D., Lo C.M., Man K., Artegiani B., Clevers H., Yan H.H.N., Leung S.Y., Richard S., Guan X., Huen M.S.Y. and Ma S.K.Y., Protein arginine methyltransferase PRMT6 regulates RAS/RAF binding and MEK/ERK-mediated cancer stemness activities in hepatocellular carcinoma through CRAF methylation, Cell Reports. 2018.

HU C. and Ching Y.P., Characterization of P21-activated kinase 4 phosphorylation substrate and intracellular inhibitor in hepatocellular carcinomav, 23rd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2018.

HU C., XIA X., Yu C. and Ching Y.P., Inhibition of P21-activated protein kinase 4 suppresses the formation of invadopodia, In: The Invadosome Consortium in. London, UK., Mechano-Chemical Signals in Invasion 2019 (7th Meeting). London, UK, 2019.

HU C. and Ching Y.P., The Regulation of TAX1 Binding Protein 2 by P21-activated Protein Kinase 4 in Liver Cancer Metastasis, 2019 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2019.

YEUNG S.F., Lai W.L. and Ching Y.P., PLK4 induce HCC migration via activation of Aurora A, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

YEUNG S.F. and Ching Y.P., The Polo-like kinase 4 promotes HCC migration via activation of Aurora A, RPG Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong. 2019.

YEUNG S.F. and Ching Y.P., The role of PLK4 in HCC progression, 23rd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2018.

ZOU W., Li S.K. and Ching Y.P., Transcriptional regulation of TAX1BP2 in hepatocellular carcinoma, 23rd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2018.

ZOU W., Li S.K. and Ching Y.P., Transcriptional regulation of TAX1BP2 in hepatocellular carcinoma, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

ZOU W., Li S.K. and Ching Y.P., Transcriptional regulation of TAX1BP2, a putative tumor suppressor in hepatocellular carcinoma, 2019 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2019.

Researcher : Choi NTV

List of Research Outputs

LIU M., Cheung Y.W., Yu Y.Y., Choi N.T.V. and Tanner J.A., Development of Nucleic Acid Aptamer-functionalized Regenerative Medicine for Regenerative Applications, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

LIU M., YU Y., Cheung Y.W., Choi N.T.V. and Tanner J.A., Development of aptamer inhibitors against ADAMTS-5 for osteoarthritis disease, Aptamers 2019, 6th Oxford Symposium on Aptamers, Oxford University, United Kingdom. 2019.

WANG N., Li C., Choi N.T.V., Wang C., Yang Y. and Gao B., The molecular basis of carpal tunnel syndrome, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

Researcher : Chung SK

Project Title:	To determine the role of Exchange Proteins Directly Activated by cAMP (Epac) in the gut microbiota-mediated metabolic syndrome
Investigator(s):	Chung SK
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2015

Project Title:	To determine the role of exchange protein directly activated by cAMP in the blood-retinal barrier and pathogenesis of diabetic retinopathy
Investigator(s):	Chung SK
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2016
Completion Date:	10/2019

Project Title:	Interaction between activated aldose reductase, non-enzymatic glycation, PKC and hexosamine pathways for the pathogenesis of diabetic complications
Investigator(s):	Chung SK
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2016

Project Title:	Cellular Mechanisms of Synaptic Functions and Plasticity in Health and Neurodegenerative Diseases
Investigator(s):	Chung SK
Department:	School of Biomedical Sciences
Source(s) of Funding:	Areas of Excellence Scheme
Start Date:	06/2017

List of Research Outputs

Ng C.L., Jian M., Bunting M., Ma K.F.O., Chung S.K. and Chan K.H., Adiponectin deficiency exacerbated neuropathologenesis and cognitive functions in Alzheimer’s disease mice: potential application of AdipoRon as Alzheimer’s disease treatment, 24th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2019, 25(1)(Supplement 1): 35.

Ni Y., Zhou N., Xue W., Rong L., Yung W.H., Lin R.Z., Kao Y.T., Duan Z.G., Sun H., Gong H., Tang X.M., Liu M.F., Zhang W., Qi S., Chung S.K., Song Y. and Huang J., A new role of anterograde motor Kif5b in facilitating large clathrin-coated vesicle mediated endocytosis via regulating clathrin uncoating, Cell Discovery. 2018, 4.

TAI W.L., Pan Z., Sun L.T., Li H., GU P., Wong S.C.S., Chung S.K. and Cheung C.W., Suppression of Pax2 Attenuates Allodynia and Hyperalgesia through ET-1–ETAR–NFAT5 Signaling in a Rat Model of Neuropathic Pain, Neuroscience. 2018, 384: 139-151.

Researcher : DIRKZWAGER RM

List of Research Outputs

Cheung Y.W., Dirkzwager R.M., Wong W.C., Cardoso J., D'Arc Neves Costa J. and Tanner J.A., Aptamer-mediated Plasmodium-specific diagnosis of malaria, Biochimie. 2018, 145: 131-136.

Fraser L.A., Kinghorn A.B., Dirkzwager R.M., Liang S., Cheung Y.W., Lim B., Shiu C.C., Tang S.L.M., Andrew D., Manitta J., Richards J.S. and Tanner J.A., A portable microfluidic Aptamer-Tethered Enzyme Capture (APTEC) biosensor for malaria diagnosis, Biosensors and Bioelectronics. 2018, 100(Supplement C): 591-596.

Miranda G.F., Feng L., SHIU C.C., DIRKZWAGER R.M., Cheung Y.W. and Tanner J.A., Aptamer-based electrochemical biosensor for highly sensitive and selective malaria detection with adjustable dynamic response range and reusability, 11th International Workshop on Impedance Spectroscopy, Chemnitz, Germany. 2018.

Tang S.L.M., Shiu C.C., Godonoga M., Cheung Y.W., Liang S., Dirkzwager R.M., Kinghorn A.B., Fraser L.A., Heddle J.G. and Tanner J.A., An aptamer-enabled DNA nanobox for protein sensing, Nanomedicine: Nanotechnology, Biology and Medicine. 2018, 14(4): 1161-1168.

Researcher : DONG C

List of Research Outputs

AN L., DONG C., LI J., CHEN J., Yuan J., Huang J., Chan K.M., Yu C. and Huen M.S.Y., RNF169 limits 53BP1 deposition at DSBs to stimulate single-strand annealing repair, Proc Natl Acad Sci U S A. 2018, 115(35): E8266-E8295.

DONG C., LI J. and Huen M.S.Y., DYRK1B Promotes Transcription Silencing on the Damaged Chromatin to Facilitate DSB Repair, 2019 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2019.

DONG C., WANG R., LI J., Huang J. and Huen M.S.Y., Fine-tuning of Transcriptional Activities at DSBs by the DYRK1 Kinases, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

DONG C., LI J., Huang J. and Huen M.S.Y., Fine-tuning of Transcriptional Activities at DSBs by the DYRK1B Kinase, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

DONG C., WANG R., LI J., Huang J. and Huen M.S.Y., Fine-tuning of transcriptional activities at DSBs by the DYRK1 kinases, 23rd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2018.

Researcher : DONG R

List of Research Outputs

LIN X., FENG D., DONG R., Lai K.O. and Gao B., Identification and characterization of the interactome of core Planar cell polarity (PCP) protein Vangl2, 2019 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2019.

LO H.Y.L., DONG R., LYU Q. and Lai K.O., The protein arginine methyltransferase PRMT8 regulates actin polymerization that is crucial for dendritic spine maturation and social behavior, 13th Annual Canadian Neuroscience Meeting. 2019.

LO H.Y.L., DONG R., LYU Q. and Lai K.O., The protein arginine methyltransferase PRMT8 regulates dendritic spine maturation and localization of excitatory synapses, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

LO H.Y.L., DONG R., LYU Q. and Lai K.O., The protein arginine methyltransferase PRMT8 regulates dendritic spine maturation and localization of excitatory synapses, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

Researcher : Deng J

List of Research Outputs

Wang F., Ye Z., Deng J., Siu K.L., Gao W., Chaudhary V., Cheng Y., Fung S.Y., Yuen K.S., Ho T.H., Chan C.P., Zhang Y., Kok K.H., Yang W., Chan C.P. and Jin D., Inhibition of AIM2 inflammasome activation by a novel transcript isoform of IFI16. , EMBO reports. 2018.

Researcher : Dirkzwager RM

List of Research Outputs

Cheung Y.W., Dirkzwager R.M., Wong W.C., Cardoso J., D'Arc Neves Costa J. and Tanner J.A., Aptamer-mediated Plasmodium-specific diagnosis of malaria, Biochimie. 2018, 145: 131-136.

Researcher : Dung WF

List of Research Outputs

Wang C., Tan Z., Niu B., Tsang K.Y., Tai C.P., Chan W.C.W., Lo R.L.K., Leung K.K.H., Dung W.F., Itoh N., Zhang M.Q., Chan D. and Cheah K.S.E., Inhibiting the integrated stress response pathway prevents aberrant chondrocyte differentiation thereby alleviating chondrodysplasia, eLife. 2018, 7: e37673.

Researcher : FAN R

List of Research Outputs

FAN R., TAM K.K., CHAN H.L., Huang J. and Lai K.O., Elucidating the non-redundant role of different Kinesin 1 motor proteins in dendritic mRNA transport of neuron, 2019 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2019.

FAN R., CHAN H.L., Huang J. and Lai K.O., Elucidating the non-redundant role of different Kinesin 1 motor proteins in dendritic mRNA transport of neuron, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

LYU Q., FAN R., Tsui Y.P., Chan Y.S., Shum D.K.Y. and Lai K.O., ) The use of genome-editing to study the pathophysiological mechanism of brain disorders in human induced pluripotent stem cell (iPSC), Abstracts of 14^th International Symposium on Healthy Aging. 2019, P61.

LYU Q., FAN R., Tsui Y.P., Chan Y.S., Shum D.K.Y. and Lai K.O., A knock-in strategy to study protein localization in human induced pluripotent stem cell (iPSC)-derived cortical neuron through genome editing, 13th Annual Canadian Neuroscience Meeting. 2019.

LYU Q., FAN R., ZHAO J., Tsui Y.P., Chan Y.S., Shum D.K.Y. and Lai K.O., A knock-in strategy to study protein localization in human induced pluripotent stem cell (iPSC)-derived cortical neuron through genome editing, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

Researcher : FANG H

List of Research Outputs

FANG H. and Wong W.H.J., Distinct POLE exonuclease domain somatic mutations are associated with genome-wide mutational patterns and a specific TP53 nonsense mutation in cancer , 2019 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2019.

FANG H. and Wong W.H.J., Distinct POLE exonuclease domain somatic mutations are associated with genome-wide mutational patterns and a specific TP53 nonsense mutation in cancer, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

Researcher : FENG D

List of Research Outputs

LIN X., FENG D., DONG R., Lai K.O. and Gao B., Identification and characterization of the interactome of core Planar cell polarity (PCP) protein Vangl2, 2019 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2019.

YANG W., FENG D., Yang Y. and Gao B., Wnt-induced Vangl2 phosphorylation is dose-dependently required for planar cell polarity in mammalian development, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

Researcher : FENG R

List of Research Outputs

FENG R., Effects of deletion of StAR-related lipid transfer domain protein 13 (STARD13) / Deleted in Liver Cancer 2 (DLC2) in diabetic neuropathy and regeneration (PhD Thesis), The University of Hong Kong. 2018.

Researcher : FENG Z

List of Research Outputs

FENG Z., NIU G. and Song Y., Genome-wide evaluation of the pathway activity profiles of APOE ε4 negative Alzheimer’s Disease cohorts using germline genetics, 2019 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2019.

Zhang Y., Cao F., Zhou Y., Feng Z., Sit B., Krendel M. and Yu C., Tail domains of myosin-1e regulate phosphatidylinositol signaling and F-actin polymerization at the ventral layer of podosomes, Molecular Biology of the Cell. 2019, mbc.E18-06-0398.

Researcher : FOK HK

List of Research Outputs

FOK H.K., Lai K.O., Huang J. and Lai S.W.C., The Role of KIF5B, isoform of Kinesin 1 in Learning and Memory, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

FOK H.K., Lai K.O., Huang J. and Lai S.W.C., The role of KIF5B trafficking in learning and memory, 23rd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2018.

Researcher : FRASER LA

List of Research Outputs

FRASER L.A., A Multidisciplinary Approach to Develop Aptamer-Based Biosensors for Malaria Diagnosis (PhD Thesis), The University of Hong Kong. 2018.

FRASER L.A., Cheung Y.W., Kinghorn A.B., Guo W., SHIU C.C., JINATA C., LONG F., BHUYAN S.K., Nan L., Shum H.C. and Tanner J.A., Microfluidic Technology for Nucleic Acid Aptamer Evolution and Application, Advanced Biosystems. 2019, 3: 1900012.

Fraser L.A., Kinghorn A.B., Dirkzwager R.M., Liang S., Cheung Y.W., Lim B., Shiu C.C., Tang S.L.M., Andrew D., Manitta J., Richards J.S. and Tanner J.A., A portable microfluidic Aptamer-Tethered Enzyme Capture (APTEC) biosensor for malaria diagnosis, Biosensors and Bioelectronics. 2018, 100(Supplement C): 591-596.

SHIU C.C., FRASER L.A., Ding Y. and Tanner J.A., Aptamer Display on Diverse DNA Polyhedron Supports, Molecules. 2018, 23: 1695.

Tang S.L.M., Shiu C.C., Godonoga M., Cheung Y.W., Liang S., Dirkzwager R.M., Kinghorn A.B., Fraser L.A., Heddle J.G. and Tanner J.A., An aptamer-enabled DNA nanobox for protein sensing, Nanomedicine: Nanotechnology, Biology and Medicine. 2018, 14(4): 1161-1168.

Researcher : Fan Y

List of Research Outputs

Bao S., Jia L., Zhou X., ZHANG Z., Wu W.L., Yu Z., NG G.C.T., Fan Y., Wong S.M., Huang S., To K.K.W., Yuen K.Y., Yeung M.L. and Song Y., Integrated analysis of mRNA-seq and miRNA-seq for host susceptibilities to influenza A (H7N9) infection in inbred mouse lines, Functional & Integrative Genomics. 2018, 18: 411-424.

Khanshour A.M., Kou I., Fan Y., Einarsdottir E., Makki N., Kidane Y.H., Kere J., Grauers A., Johnson T.A., Patel C., Singhania R., Kamiya N., Takeda N., Takeda K., Otomo N., Watanabe K., Luk K.D.K., Cheung K.M.C., Herring J., Rios J.J., Ahituv N., Gerdhem P., Gurnett C.A., Song Y., Ikegawa S. and Wise C.A., Genome-wide meta-analysis and replication studies in multiple ethnicities identify novel adolescent idiopathic scoliosis susceptibility loci, Human Molecular Genetics. 2018, 27: 3986-3998.

Kou I., Watanabe K., Takahashi Y., Momozawa Y., Khanshour A., Grauers A., Zhou H., Liu G., Fan Y., Takeda K., Ogura Y., Zhou T., Iwasaki Y., Kubo M., Wu Z., Matsumoto M., JSCRG J., TSRHCCG T., Einarsdottir E., Kere J., Huang D., Qiu G., Qiu Y., Wise C.A., Song Y., WU N., SU P., Gerdhem P. and Ikegawa S., A multi-ethnic meta-analysis confirms the association of rs6570507 with adolescent idiopathic scoliosis, Sci Rep.. 2018, 8(1): 11575.

Liu J., Zhou Y., Liu S., Song X., Yang X.Z., Fan Y., Chen W., Akdemir Z.C., Yan Z., Zuo P., Du R., Liu Z., Yuan B., Zhao S., Liu G., Chen Y., Zhao Y., Lin M., Zhu Q., Niu Y., Liu P., Ikegawa S., Song Y., Posey J.E., Qiu G., DISCO S., Zhang F., Wu Z., Lupski J.R. and Wu N., The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease, Hum Genet. 567, 2018, 137(6-7): 553.

Ogura Y., Takeda K., Kou I., Khanshour A., Grauers A., Zhou H., LIU G., Fan Y., ZHOU T., WU Z., Takahashi Y., Matsumoto M., Einarsdottir E., Kere J., Huang D., QIU G., XU L., QIU Y., WISE S.A., Song Y., WU N., SU P., Gerdhem P., Watanabe K. and Ikegawa S., An international meta-analysis confirms the association of BNC2 with adolescent idiopathic scoliosis, Scientific Reports. 2018, 8.

Wang B., Bao S., ZHANG Z., ZHOU X., WANG J., Fan Y., Zhang Y., Li Y., Chen L.P., Jia Y., LI J., Li M., Zheng W., Mu N., Yang W., Yu Z., Lau D.S.S., Wong S.M., ZHANG Y., Kwan J.S.K., Mak H.K.F., Ambalavanan A., Zhou S., Cai W., Zheng J., Huang S., Rouleau G.A., Yang W., Rogaeva E., Ma X., St George-Hyslop P., Chu L.W. and Song Y., A rare variant in MLKL confers susceptibility to ApoE ɛ4-negative Alzheimer's disease in Hong Kong Chinese population, Neurobiol Aging. 2018, 68:160: e1-e7.

Researcher : Feng W

Project Title:	Maintenance of Genome Stability 2014; A role of NIRR in replicative stress responses
Investigator(s):	Feng W
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2014

Researcher : Fraser LA

List of Research Outputs

FRASER L.A., A Multidisciplinary Approach to Develop Aptamer-Based Biosensors for Malaria Diagnosis (PhD Thesis), The University of Hong Kong. 2018.

SHIU C.C., FRASER L.A., Ding Y. and Tanner J.A., Aptamer Display on Diverse DNA Polyhedron Supports, Molecules. 2018, 23: 1695.

Researcher : Fu C

Project Title:	Systematic investigation of the roles of mitotic kinesins in spindle dynamics
Investigator(s):	Fu C
Department:	School of Biomedical Sciences
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2013

Project Title:	Molecular mechanisms of nuclear congression
Investigator(s):	Fu C
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016

Researcher : Fung ML

Project Title:	Pathophysiological role of local inflammation in nitric oxide deficit in the carotid body in intermittent hypoxia
Investigator(s):	Fung ML
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2016

Project Title:	Pathophysiological roles of monoamine oxidase A in the oxidative stress and hippocampal neurodegeneration induced by chronic intermittent hypoxia
Investigator(s):	Fung ML
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017
Completion Date:	05/2019

List of Research Outputs

Kang J.J., Guo B., Liang W.H., Lam C.S., Wu S.X., Huang X.F., Wong R.I.L.E.Y. .M.T.T., Fung M.L. and Liu Y.Y., Daily acute intermittent hypoxia induced dynamic changes in dendritic mitochondrial ultrastructure and cytochrome oxidase activity in the pre-Bötzinger complex of rats, Exp Neurol. 2019, 313: 124-134.

Lee Y.K.M., Ge M., Fung M.L., Vanhoutte P.M.G.R., Mak J.C.W. and Ip M.S.M., Low but not high frequency of intermittent hypoxia suppresses endothelium-dependent, oxidative stress-mediated contractions in carotid arteries of obese mice, Journal of Applied Physiology. 2018, 125: 1384-1395.

Lin R., Duan Z., Sun H., Fung M.L., Chen H., Wang J., Lau C.F., Yang D., Liu Y., Ni Y., Wang Z., Cui J., Wu W., Yung W.H., Chan Y.S., Lo A.C.Y., Xia J., Shen J. and Huang J., Kinesin-1 Regulates Extrasynaptic Targeting of NMDARs and Neuronal Vulnerability Toward Excitotoxicity, iScience. 2019, 13: 82-97.

SAW Y.L., MUHAMMAD SHARAFUDDIN BIN M.K., Tipoe G.L., Fung M.L. and Lim L.W., Investigation of stimulation parameters and neuroinflammation by electrical stimulation of the medial prefrontal cortex in an animal model of depression, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

SAW Y.L., Tipoe G.L., Fung M.L. and Lim L.W., Prelimbic cortical stimulation ameliorates the neuroinflammatoryinduced depressivelike and social behavioral deficits in rat models, 2019 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2019.

Researcher : Fung SY

List of Research Outputs

CHEUNG P.H.H., Fung S.Y., Yuen K.Y., Chen H. and Jin D., Influenza A virus PB1-F2 protein suppresses IL-1β production from human macrophages by enhancing MAVS degradation, The American Society for Virology 37th Annual Meeting, University of Maryland, College Park, Maryland, USA, July 14-18, 2018.. 2018.

Chan C.P., Yuen C.K.J., CHEUNG P.H.H., Fung S.Y., Lui P.Y., Chen H., Kok K.H. and Jin D., Antiviral activity of double-stranded RNA–binding protein PACT against influenza A virus mediated via suppression of viral RNA polymerase, The FASEB Journal. 2018, 32: 4380-4393.

Fung S.Y., Chan C.P., Zhu L., Yuen K.Y., Woo P.C.Y., Cai Z. and Jin D., Middle East respiratory syndrome coronavirus ORF4b protein targets cGAS-STING pathway of nucleic acid sensing., Keystone Symposium on “Framing the Response to Emerging Virus Infections“, Pokfulam, Hong Kong. 2018.

Fung S.Y., Cheung P.H.H., Chan C.P. and Jin D., Perturbation of innate DNA sensing by human RNA viruses., The 7th Cross Straight Immunology Conference. 2018.

Jin D., Chan C.P., Fung S.Y., Yuen K.S. and Chan C.P., Anti-HTLV-1 activity of SAMHD1 in resting T cells, HTLV 2019: 19th International Conference on Human Retrovirology, Lima, Peru. 2019.

WONG L.Y.R., Lui P.Y., Siu K.L., Yeung M.L., Yuen K.S., Fung S.Y., Chan C.P., Woo P.C.Y., Yuen K.Y. and Jin D., Middle-East respiratory syndrome coronavirus ORF8b protein suppresses type I interferon production by interacting with HSP70, The American Society for Virology 37th Annual Meeting, University of Maryland, College Park, Maryland, USA, July 14-18, 2018.. 2018.

WONG L.Y.R., Ye Z., Lui P.Y., Siu K.L., Yeung M.L., Yuen K.S., Fung S.Y., Chan C.P., Cai Z., Woo P.C.Y., Yuen K.Y. and Jin D., Suppression of type I interferon production by Middle East respiratory syndrome coronavirus ORF8b accessory protein through interaction with HSP70 chaperone, Keystone Symposium on “Framing the Response to Emerging Virus Infections”, Pokfulam, Hong Kong. 2018.

Wang F., Ye Z., Deng J., Siu K.L., Gao W., Chaudhary V., Cheng Y., Fung S.Y., Yuen K.S., Ho T.H., Chan C.P., Zhang Y., Kok K.H., Yang W., Chan C.P. and Jin D., Inhibition of AIM2 inflammasome activation by a novel transcript isoform of IFI16. , EMBO reports. 2018.

Researcher : GUO S

List of Research Outputs

Cheah K.S.E., Guo S., Chen P., Au Y.K., Niu B., Wu R., Cheung K.M.C., Cheung J.P.Y., Sakai D., Chan D., Zhang M.Q., Richardson S. and Hoyland J., Insights into the cellular basis of intervertebral disc disease gained from the transcriptomes of single cells., Gordon Research Conference on Cartilage Biology and Pathology.. 2019.

GUO S. and Cheah K.S.E., Poster Presentation Prize “Single cell analyses of human intervertebral discs implicate HOPX as a regulator of homeostasis”, Research Day, School of Biomedical Sciences, the University of Hong Kong, December 14, 2018.. 2018.

GUO S., Chen P., Tan Z., Au Y.K., Niu B., Tam V., Cheung K.M.C., Cheung J.P.Y., Chan D., Sham P.C., Sakai D., Rickardson S., Hoyland J. and Cheah K.S.E., Single cell analyses of human intervertebral discs implicate HOPX as a regulator of homeostasis, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

Researcher : GUO Y

List of Research Outputs

Sy M.H., GUO Y., Lan Y., Ng H.W.H., Miao X. and Huen M.S.Y., Stabilization Of Imprinted Retrotransposon-derived Gene Peg10 By Deubiquitinase Usp9x, 2018 Gorden Research Conference: genomic instability. 2018.

Researcher : Gao B

Project Title:	Genetic Studies of Congenital Scoliosis
Investigator(s):	Gao B, Cheung JPY, Song Y
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2017

Project Title:	Regulation of non-canonical Wnt/PCP signaling by Vangl2 phosphorylation
Investigator(s):	Gao B
Department:	School of Biomedical Sciences
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	07/2017

Project Title:	Understanding the molecular basis of Carpal Tunnel Syndrome
Investigator(s):	Gao B, Fok MWM, Chan D
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2018

Project Title:	Elucidating the Role of ER stress/UPR in Carpal Tunnel Syndrome
Investigator(s):	Gao B
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2018

Project Title:	Cartilage Biology and Pathology 2019; Non-canonical Wnt/Planar Cell Polarity signaling in cartilage development
Investigator(s):	Gao B
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2019
Completion Date:	03/2019

Project Title:	Understanding the regulatory mechanism of Vangl2 ubiquitination
Investigator(s):	Gao B, Huen MSY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2019

Project Title:	Identifying the genetic factors underlying congenital scoliosis in Hong Kong
Investigator(s):	Gao B, Cheung JPY, Song Y
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2019

List of Research Outputs

Gao B., Wnt Regulation of Planar Cell Polarity, International Forum of Genetics and Epigenetics in Precision Medicine. 2019.

Gao B., Wnt Regulation of Planar Cell Polarity, Joint Symposium on Biomedical Sciences by School of Biomedical Sciences of HKU and Faculty of Health Sciences of University of Macau. 2019.

LIN X., FENG D., DONG R., Lai K.O. and Gao B., Identification and characterization of the interactome of core Planar cell polarity (PCP) protein Vangl2, 2019 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2019.

WANG N., Li C., Choi N.T.V., Wang C., Yang Y. and Gao B., The molecular basis of carpal tunnel syndrome, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

YANG W., FENG D., Yang Y. and Gao B., Wnt-induced Vangl2 phosphorylation is dose-dependently required for planar cell polarity in mammalian development, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

Researcher : Gao W

List of Research Outputs

Leung K.C., Luk H.M., Tang H.M.V., Gao W., MAK C.C.Y., YU H.C., Wong W.L., Chu W.Y., Yang W., Wong W.H.S., Ma C.H., Leung A.Y.H., Jin D., Chan Y.K., Allanson J., Lo F.M.I. and Chung B.H.Y., Integrating Functional Analysis in the Next-Generation Sequencing Diagnostic Pipeline of RASopathies, Scientific Reports. 2018, 8: 2421.

Wang F., Ye Z., Deng J., Siu K.L., Gao W., Chaudhary V., Cheng Y., Fung S.Y., Yuen K.S., Ho T.H., Chan C.P., Zhang Y., Kok K.H., Yang W., Chan C.P. and Jin D., Inhibition of AIM2 inflammasome activation by a novel transcript isoform of IFI16. , EMBO reports. 2018.

Researcher : Gong H

List of Research Outputs

Ni Y., Zhou N., Xue W., Rong L., Yung W.H., Lin R.Z., Kao Y.T., Duan Z.G., Sun H., Gong H., Tang X.M., Liu M.F., Zhang W., Qi S., Chung S.K., Song Y. and Huang J., A new role of anterograde motor Kif5b in facilitating large clathrin-coated vesicle mediated endocytosis via regulating clathrin uncoating, Cell Discovery. 2018, 4.

Researcher : Guan L

List of Research Outputs

YU W.S., Guan L., Shrestha S., Or Y., Lufkin T., Chan Y.S., Lin V.C.L. and Lim L.W., TTC9A deficiency induces social anxiety and estrogen-mediated alterations on amygdala-hippocampal neuroplasticity-related gene expression of mice, 23rd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2018.

Researcher : HAN L

List of Research Outputs

CUI D., Han L., ZHU Y., YAN D., Tsao G.S.W. and Cheung A., Role and mechanism of miR-338-5p in regulating metastasis of esophageal cancer, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

Han L. and Chan Y.S., Developmental profile of spontaneous transient outward currents in rat medial vestibular nucleus, Abstracts of 11^th FENS Forum of Neuroscience. 2018, 825.

Li B., Hong P., Zheng C.C., Dai W., Chen W.Y., Yang Q.S., Han L., Tsao G.S.W., Chan K.T., Lee N.P.Y., Law S.K., Xu L.Y., Li E.M., Chan K.W., Qin Y.R., Guan X., Lung M.L., He Q.Y., Xu W.W. and Cheung A., Identification of miR-29c and its Target FBXO31 as a Key Regulatory Mechanism in Esophageal Cancer Chemoresistance: Functional Validation and Clinical Significance., Theranostics 2019. 2019, 9(6):1599-1613.

Li B., Hong P., Zheng C.-.C., Dai W., Chen W.-.Y., Yang Q.-.S., HAN L., Tsao G.S.W., Chan K.T., Lee N.P.Y., Law S.Y.K., Xu L.Y., Li E.M., Chan K.W., Qin Y.R., Guan X., Lung M.L., He Q.-.Y., Xu W. and Cheung A., Identification of miR-29c and its Target FBXO31 as a Key Regulatory Mechanism in Esophageal Cancer Chemoresistance: Functional Validation and Clinical Significance, Theranostics. 2019, 9: 1599-1613.

NG H.L.L., HUANG Y., Han L., Chang R.C.C., Chan Y.S. and Lai S.W.C., Ketamine and selective activation of parvalbumin interneurons inhibit stress-induced dendritic spine elimination., Translational psychiatry . 2018, 8.

Peng Y.J., Zheng C.X., Chen X., Han L., Li M., Zhang G., Jiang H., Chan Y.S., Lau G.C. and He J., CCK released by entorhinal cortical neurons enables visuo-auditory associative learning, Gordon Research Conference – Neuroplasticity and Maladaptation of Sensory Systems. HK. June 3-8, 2018]. 2018.

Researcher : HAU WF

List of Research Outputs

Shum D.K.Y., KWAN P.Y., Ho S.N.S., Hau W.F., Tam K.W., Wu L.K., Ma C.W. and Chan Y.S., Dynamics of perineuronal net-associated plastic factors after sensory loss, Abstracts of 15^th Meeting of Asian-Pacific Society for Neurochemistry [Macau. Aug. 27-29, 2018]. 2018, 80.

Shum D.K.Y., KWAN P.Y., HAU W.F., Tam K.W., Wu L.K., Ma C.W. and Chan Y.S., Dynamics of perineuronal net-associated plastic factors after sensory loss, Abstracts of 15^th Meeting of Asian-Pacific Society for Neurochemistry, 80. [Macau. Aug. 27-29, 2018]. 2018, 80.

Wu L.K., Ho S.N., Hau W.F., Ma C.W., Shum D.K.Y. and Chan Y.S., Dynamics of perineuronal net-associated plastic factors after sensory loss, 11th FENS Forum of Neuroscience. 2018.

Wu L.K., Ho S.S.N., HAU W.F., Ma C.W., Shum D.K.Y. and Chan Y.S., Dynamics of perineuronal net-associated plastic factors after sensory loss, Abstracts of 11^th FENS Forum of Neuroscience. 2018, 1106.

Researcher : HO TH

List of Research Outputs

HO T.H., Identification of Epstein-Barr virus proteins that inhibit the DNA damage response (PhD Thesis), The University of Hong Kong. 2018.

Jin D., CHENG T.F., HO T.H. and Yuen K.S., Caspase 3 activation facilitates Epstein-Barr virus lytic replication in epithelial cells, 2018 International Conference on EBV & KSHV. University of Wisconsin – Madison, Wisconsin, USA, July 28 to August 1, 2018.. 2018.

Wang F., Ye Z., Deng J., Siu K.L., Gao W., Chaudhary V., Cheng Y., Fung S.Y., Yuen K.S., Ho T.H., Chan C.P., Zhang Y., Kok K.H., Yang W., Chan C.P. and Jin D., Inhibition of AIM2 inflammasome activation by a novel transcript isoform of IFI16. , EMBO reports. 2018.

Researcher : HU C

List of Research Outputs

HU C. and Ching Y.P., Characterization of P21-activated kinase 4 phosphorylation substrate and intracellular inhibitor in hepatocellular carcinomav, 23rd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2018.

HU C., XIA X., Yu C. and Ching Y.P., Inhibition of P21-activated protein kinase 4 suppresses the formation of invadopodia, In: The Invadosome Consortium in. London, UK., Mechano-Chemical Signals in Invasion 2019 (7th Meeting). London, UK, 2019.

HU C. and Ching Y.P., The Regulation of TAX1 Binding Protein 2 by P21-activated Protein Kinase 4 in Liver Cancer Metastasis, 2019 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2019.

Researcher : HU F

List of Research Outputs

YANG X., HU F., Cheung M.P.L., LUNG H.L. and Cheung M.C.H., DLC1 promotes melanoma invasion through activation of MMP9 by interaction with FOXK1, 2019 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2019.

Researcher : HUANG Y

List of Research Outputs

NG H.L.L., HUANG Y., Han L., Chang R.C.C., Chan Y.S. and Lai S.W.C., Ketamine and selective activation of parvalbumin interneurons inhibit stress-induced dendritic spine elimination., Translational psychiatry . 2018, 8.

Researcher : HUNG CH

List of Research Outputs

HUNG C.H., The Role of Intracellular Ca²⁺ Channels in Airway Remodeling of an Asthmatic Mouse Model (PhD Thesis), The University of Hong Kong. 2018.

Researcher : HUNG TN

List of Research Outputs

Jin D., CHENG T., HUNG T.N., Kong K.Y. and Chan C.P., Suppression of hepatitis B virus transcription by RFWD2 ubiquitin ligase, 2018 International HBV Meeting: The Molecular Biology of Hepatitis B Viruses. Palazzo dei Congressi, Piazza Vittorio Emanuele Taormina (Messina), Italy, October 3-6, 2018.. 2018.

Researcher : Han L

Project Title:	11th Federation of European Neurosciences Societies forum; Developmental profile of spontaneous transient outward currents in rat medial vestibular nucleus
Investigator(s):	Han L
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2018
Completion Date:	07/2018

List of Research Outputs

Han L. and Chan Y.S., Developmental profile of spontaneous transient outward currents in rat medial vestibular nucleus, Abstracts of 11^th FENS Forum of Neuroscience. 2018, 825.

Researcher : Han L

List of Research Outputs

Han L. and Chan Y.S., Developmental profile of spontaneous transient outward currents in rat medial vestibular nucleus, Abstracts of 11^th FENS Forum of Neuroscience. 2018, 825.

Researcher : Hao Q

Project Title:	Investigation of pathogenesis mechanism of two infectious fungi Penicillium marneffei and Aspergillus fumigatus
Investigator(s):	Hao Q
Department:	School of Biomedical Sciences
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2014

Project Title:	Novel Structure and Function of Human Sirtuins
Investigator(s):	Hao Q, Huang J, Li XD
Department:	School of Biomedical Sciences
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	03/2015

Project Title:	Structural study of NDM-1: Towards rational inhibitor design against the antibiotic resistant “superbug”
Investigator(s):	Hao Q
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2016
Completion Date:	01/2019

Project Title:	Development of novel inhibitors targeting the resistance mechanisms of clinical superbugs
Investigator(s):	Hao Q
Department:	School of Biomedical Sciences
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2017

Project Title:	Structural and functional studies of the YEATS domain of GAS41
Investigator(s):	Hao Q
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2018

Project Title:	Asian Biophysics Association (ABA) Symposium; Structural studies of new post-translational modification erasers/readers.
Investigator(s):	Hao Q
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	12/2018

List of Research Outputs

Hao Q., Structural studies of new post-translational modification erasers/readers, Asian Biophysics Association Meeting, Melbourne, Australia. 2018.

Hao Q., Using Cryo-EM maps for X-ray Structure Determination, National Cryo-EM Meeting, Beijing, China. 2019.

Huang H., Zhang D., Wang Y., Perez-Neut M., Han Z., Zheng Y.G., Hao Q. and Zhao Y.M., Lysine benzoylation is a histone mark regulated by SIRT2, Nature Communications. 2018, 9.

Lam W.H., Sze K.H., Ke Y., Tse M.K., Zhang H., Woo P.C.Y., Lau S.K.P., Lau C.C.Y., Xu S., Lai P.M., Zhou T., Antonyuk S.V., Kao R.Y.T., Yuen K.Y. and Hao Q., Talaromyces marneffei Mp1 Protein, a Novel Virulence Factor, Carries Two Arachidonic Acid-Binding Domains To Suppress Inflammatory Responses in Hosts , Infection and Immunity. 2019, 87.

WAN W., Kao R.Y.T. and Hao Q., The apo structure of Dehydrosqualene Desaturase and the co-crystal structure with inhibitors, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

WU Y. and Hao Q., NDM-1 with cadmium substitution reveals initiate state of beta-lactam hydrolysis, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

Wang H., Wang M., Yang X., XU X., Hao Q., Yan A., Hu M., Lobinski R., Li H. and Sun H., Antimicrobial silver targets glyceraldehyde-3-phosphate dehydrogenase in glycolysis of E. coli , Chemical Science. 2019, 10: 7193-7199.

ZENG L., Ding W. and Hao Q., Using cryo-electron microscopy maps for X-ray structure determination, IUCrJ. 2018, 5: 382-389.

ZENG L., Ding W. and Hao Q., Using cryo-electron microscopy maps for X-ray structure determination, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

Zhang H., Ma G., Zhu Y., ZENG L., Ashmad A., Wang C., Pang B., Fang H., Zhao L. and Hao Q., Active site conformational fluctuations promote the enzymatic activity of NDM-1, Antimicrobial Agents and Chemotherapy. 2018.

Researcher : Hau WF

List of Research Outputs

Wu L.K., Ho S.N., Hau W.F., Ma C.W., Shum D.K.Y. and Chan Y.S., Dynamics of perineuronal net-associated plastic factors after sensory loss, 11th FENS Forum of Neuroscience. 2018.

Researcher : Ho CC

List of Research Outputs

Fryer L.K., Zeng M., Wong C.W., Ho C.C. and Chiu P., On-task student-to-teacher feedback: “Was that interesting?” &”Does it Matter”, EARLI SIG 4 Conference Topography of research on higher education: Promoting deep conversations. 2018.

Researcher : Ho JWK

List of Research Outputs

Djordjevic D., Cawood B.K., Rispin S.K., Shah A., Yim L.H.H., Hayward C.S. and Ho J.W.K., CardiacProfileR: an R package for extraction and visualisation of heart rate profiles from wearable fitness trackers, Biophysical Reviews. 2019, 11: 119-121.

Djordjevic D., Tang J.Y.S., Chen Y.X., Kwan S.L.S., Ling R.W.K., Qian G., Woo C.Y.Y., Ellis S.J. and Ho J.W.K., Discovery of perturbation gene targets via free text metadata mining in Gene Expression Omnibus, Computational Biology and Chemistry. 2019, 80: 152-158.

Farbehi N., Patrick R., Dorison A., Xaymardan M., Janbandhu V., Wystub-Lis K., Ho J.W.K., Nordon R.E. and Harvey R.P., Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury, eLife. 2019, 8: e43882.

Ho J.W.K., AI in Genomics: scalability and validity, Medicine Meets AI 2019: East Meets West, Hong Kong Science and Technology Park, Hong Kong. 2019.

Ho J.W.K. and Giannoulatou E., Big data: the elements of good questions, open data, and powerful software, Biophysical Reviews. 2019, 11: 1-3.

Ho J.W.K. and Scadding M., Classroom Activities for Teaching Artificial Intelligence to Primary School Students, International Conference on Computational Thinking Education 2019. 157-159.

Ho J.W.K., Executive Editor, Biophysical Reviews. Springer-Nature, 2019.

Ho J.W.K., Scalable bioinformatics methods for single-cell RNA-seq analysis, IAS New Technologies and Transnational Applications in Genomics. 2018.

Kabir M.H., Djordjevic D., O’Connor M.D. and Ho J.W.K., C3: An R package for cross-species compendium-based cell-type identification, Computational Biology and Chemistry. 2018, 77: 187-192.

Kabir M.H., Patrick R., Ho J.W.K. and O’Connor M.D., Identification of active signaling pathways by integrating gene expression and protein interaction data, BMC Systems Biology. 2018, 12.

Szczesnik T., Ho J.W.K. and Sherwood R., Dam mutants provide improved sensitivity and spatial resolution for profiling transcription factor binding, Epigenetics & Chromatin. 2019, 12: 36.

Wang Q., Wang K., Wu W., Giannoulatou E., Ho J.W.K. and Li L., Host and microbiome multi-omics integration: applications and methodologies, Biophysical Reviews. 2019.

Ye X. and Ho J.W.K., Expression Clustering, Encyclopedia of Bioinformatics and Computational Biology. Elsevier, 2019, 388-395.

Ye X. and Ho J.W.K., Ultrafast clustering of single-cell flow cytometry data using FlowGrid, BMC Systems Biology. 2019, 13: 35.

van Eyk C.L., Samaraweera S.E., Scott A., Webber D.L., Harvey D.P., Mecinger O., O’Keefe L.V., Cropley J.E., Young P., Ho J.W.K., Suter C. and Richards R.I., ‘Non-self’ Mutation: Double-stranded RNA elicits antiviral pathogenic response in a Drosophila model of expanded CAG repeat neurodegenerative diseases, Human Molecular Genetics. 2019.

Researcher : Ho SNS

List of Research Outputs

Shum D.K.Y., KWAN P.Y., Ho S.N.S., Hau W.F., Tam K.W., Wu L.K., Ma C.W. and Chan Y.S., Dynamics of perineuronal net-associated plastic factors after sensory loss, Abstracts of 15^th Meeting of Asian-Pacific Society for Neurochemistry [Macau. Aug. 27-29, 2018]. 2018, 80.

Researcher : Ho TH

List of Research Outputs

HO T.H., Identification of Epstein-Barr virus proteins that inhibit the DNA damage response (PhD Thesis), The University of Hong Kong. 2018.

Researcher : Ho YS

List of Research Outputs

Ho Y.S., Lau C.F., Tang W.Y., Tian J.Y., Lee J.Q., Yung S.S.Y. and Chang R.C.C., Cognitive and pathological changes in an animal model of chronic kidney disease, The 14th International Symposium on Healthy Aging. 2019, 70.

Lee K., Lai H.M., SOERENSEN M.H., PANG C.C.C., Ho Y.S. and Chang R.C.C., Optimization of delipidation-based tissue clearing techniques for studying neuropathology in aging-associated neurodegenerative diseases, The 14th International Symposium on Healthy Aging. 2019, 62.

YOU R., Ho Y.S., Hung H.L.C., LIU Y., HUANG C., Chan H.N., Ho S.L., Lui S.Y., Li H.W. and Chang R.C.C., Silica nanoparticles induce neurodegeneration-like changes in behaviour, neuropathology, and affect synapse through MAPK activation, Particle Fibre Toxicology. 2018, 15: 28.

Researcher : Hu M

List of Research Outputs

Wang H., Wang M., Yang X., XU X., Hao Q., Yan A., Hu M., Lobinski R., Li H. and Sun H., Antimicrobial silver targets glyceraldehyde-3-phosphate dehydrogenase in glycolysis of E. coli , Chemical Science. 2019, 10: 7193-7199.

Researcher : Hu X

List of Research Outputs

Hu X., Wu L.K., Chua O.W., Shum D.K.Y. and Chan Y.S., Selective recruitment of inhibitory interneurons to vestibular microcircuits for distinct behaviour, Abstracts of 14^th International Symposium on Healthy Aging: Science and Aging –Embrace the Golden Years: P2. [HK. March 16-17, 2019]. 2019.

Researcher : Huang J

Project Title:	RNA-DNA hybrid oligonucleotide mediated site-specific repair and gene therapy
Investigator(s):	Huang J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Matching Fund for Hi-Tech Research and Development Program of China (863 Projects)
Start Date:	01/2003

Project Title:	Development of a Pan-organism Riboregulator Device
Investigator(s):	Huang J, Jin Y
Department:	School of Biomedical Sciences
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	11/2009

Project Title:	Development of a Pan-organism Riboregulator Device
Investigator(s):	Huang J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	12/2009

Project Title:	Outstanding Research Student Supervisor Award 2011-12
Investigator(s):	Huang J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Outstanding Research Student Supervisor Award
Start Date:	01/2013

Project Title:	Protein Trafficking: Mechanism and Diseases
Investigator(s):	Huang J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	04/2013

Project Title:	Non-canonical role of Kif5b in clathrin uncoating and the endocytic regulation of muscarinic acetylcholine receptors
Investigator(s):	Huang J, Ni Y
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2013

Project Title:	Bridge the gap in nerve tissue injury to promote axonal regeneration with fabrication of a bioactive nanofibrous conduit
Investigator(s):	Huang J, Wu W
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2014

Project Title:	Pattern formation by bacteria: from theoretical physics to synthetic biology
Investigator(s):	Huang J
Department:	School of Biomedical Sciences
Source(s) of Funding:	ANR / RGC Joint Research Scheme
Start Date:	01/2015

Project Title:	A feasibility study on the inhibition of Staphylococcus aureus infection using AdsA specific antibodies
Investigator(s):	Huang J, Chen Z
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2015

Project Title:	Doris Zimmern HKU-Cambridge Hughes Hall Fellowships 2015-16
Investigator(s):	Huang J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Doris Zimmern HKU-Cambridge Hughes Hall Fellowships
Start Date:	09/2015

Project Title:	Characterization of the interaction between Kif5b and NMDAR in ischemic provoked neurodegeneration
Investigator(s):	Huang J, Sze KH
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016
Completion Date:	01/2020

Project Title:	Outstanding Researcher Award 2014-15
Investigator(s):	Huang J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	02/2016

Project Title:	Virus-like particle (VLP)-based mucosal vaccine for inducing cross-serotype immunity against Streptococcus pneumoniae infection
Investigator(s):	Huang J, Ho PL, Yu B
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2017

Project Title:	Investigation of the interaction between kinesin heavy chain and kinesin light chain
Investigator(s):	Huang J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017
Completion Date:	12/2018

Project Title:	Development of virus-like particle (VLP)-based vaccine against Streptococcus pneumoniae infection
Investigator(s):	Huang J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Translational and Applied Research
Start Date:	06/2017

Project Title:	Investigating the effect of Intracellular Sigma Protein in the treatment of amyotrophic lateral sclerosis and multiple sclerosis
Investigator(s):	Huang J, Wu W, Sun H
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2018

Project Title:	Mechanistic study of bacteria capable of inhibiting adjacent cell swarming
Investigator(s):	Huang J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2018
Completion Date:	05/2019

Project Title:	Engineering bacterial outer membrane vesicles for targeted cancer immunotherapy
Investigator(s):	Huang J, Sun J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Translational and Applied Research
Start Date:	06/2018

Project Title:	Identification of E. coli factors capable of inhibiting swarming of adjacent cells
Investigator(s):	Huang J, Wang X
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research for Resubmission of GRF/ECS Proposals
Start Date:	07/2018
Completion Date:	11/2018

Project Title:	EMBO\|EMBL Symposium: Synthetic Morphogenesis: From Gene Circuits to Tissue Architecture; Pattern formation by multi-species bacterial colonies with programmed population-to-population interactions
Investigator(s):	Huang J
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2019
Completion Date:	03/2019

Project Title:	Development of Therapeutic Neoantigen-based Vaccines Against Cancers with High Local Prevalence (AoE)
Investigator(s):	Huang J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Funding for Strategic Interdisciplinary Research Scheme
Start Date:	06/2019

List of Research Outputs

ARYA S., LIN Q. and Huang J., mRNA therapeutics: a different vision, 23rd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2018.

ARYA S., Lin Q., Zhou N. and Huang J., mRNA therapeutics, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

BADEA S.-.R., RONG L., LIU R., SUN H., WU W. and Huang J., Overcoming CSPG-mediated inhibition by targeting PTPσ in experimental models of multiple sclerosis, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

Badea S., Sun H., Wu W. and Huang J., Overcoming CSPG-mediated inhibition by targeting PTPσ in experimental models of multiple sclerosis, 23rd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2018.

FAN R., TAM K.K., CHAN H.L., Huang J. and Lai K.O., Elucidating the non-redundant role of different Kinesin 1 motor proteins in dendritic mRNA transport of neuron, 2019 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2019.

FAN R., CHAN H.L., Huang J. and Lai K.O., Elucidating the non-redundant role of different Kinesin 1 motor proteins in dendritic mRNA transport of neuron, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

FOK H.K., Lai K.O., Huang J. and Lai S.W.C., The Role of KIF5B, isoform of Kinesin 1 in Learning and Memory, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

FOK H.K., Lai K.O., Huang J. and Lai S.W.C., The role of KIF5B trafficking in learning and memory, 23rd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2018.

Lin R., Duan Z., Sun H., Fung M.L., Chen H., Wang J., Lau C.F., Yang D., Liu Y., Ni Y., Wang Z., Cui J., Wu W., Yung W.H., Chan Y.S., Lo A.C.Y., Xia J., Shen J. and Huang J., Kinesin-1 Regulates Extrasynaptic Targeting of NMDARs and Neuronal Vulnerability Toward Excitotoxicity, iScience. 2019, 13: 82-97.

Liu L., Zong Z.M., Liu Q., Jiang S.S., Zhang Q., Cen L.Q., Gao J., Gao X.G., Huang J., Liu Y. and Yao H., A novel galactose-PEG-conjugated biodegradable copolymer is an efficient gene delivery vector for immunotherapy of hepatocellular carcinoma, Biomaterials. 2018, 184: 20-30.

Luo Y.S., Zhou Y., Zhang K.E., Liu X., Hofer E. and Huang J., Kif5b Modulates Processing and Secretion of von Willebrand Factor in Endothelial Cells and Mice, Cardiovascular Pharmacology: Open Access. 2018, 07.

Ni Y., Zhou N., Xue W., Rong L., Yung W.H., Lin R.Z., Kao Y.T., Duan Z.G., Sun H., Gong H., Tang X.M., Liu M.F., Zhang W., Qi S., Chung S.K., Song Y. and Huang J., A new role of anterograde motor Kif5b in facilitating large clathrin-coated vesicle mediated endocytosis via regulating clathrin uncoating, Cell Discovery. 2018, 4.

Shi L., Tang X., Qian M., Liu Z., Meng F., Fu L., Wang Z., Zhu W.G., Huang J., Zhou Z. and Liu B., A SIRT1-centered circuitry regulates breast cancer stemness and metastasis, Oncogene. 2018, 37: 6299-6315.

Zhang K., Li C., Luo Y.S., Wen L.R., Yuan S., Wang D., WONG H.Y.B., Zhao X., Chiu M.C., Ye Z., Sun Z., Zhao H., ZHANG X., Hu M., Yang D., Shuai H.V., Wang Y., He J., Bose M.E., Henrickson K.J., Huang J., Zheng B., Chu H. and Zhou J., Establishment of a lethal aged mouse model of human respiratory syncytial virus infection, Antiviral Research. 2019, 161: 125-133.

Researcher : Huen MSY

Project Title:	Role of Human Ubiquitin Machineries in DNA Damage Signaling and Repair
Investigator(s):	Huen MSY
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2016
Completion Date:	12/2018

Project Title:	Outstanding Young Researcher Award 2014-15
Investigator(s):	Huen MSY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	02/2016

Project Title:	Exploiting the potential of cyro-EM for structure-based drug design: Targeting ATM for therapeutic intervention in cancer and degenerative diseases
Investigator(s):	Huen MSY, Lau CYW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Translational and Applied Research
Start Date:	06/2016

Project Title:	Role of The USP7-RNF169 Axis in DNA Double-Strand Break Responses
Investigator(s):	Huen MSY
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2016

Project Title:	Role of The BRCA1-A Complex in DNA Repair Control
Investigator(s):	Huen MSY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017
Completion Date:	05/2019

Project Title:	A Study of TRAIP in Replicative Stress Responses: Regulation and Relevance to Seckel Syndrome
Investigator(s):	Huen MSY
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2017

Project Title:	A Study of Self-Restraining Mechanisms of DNA Damage Surveillance and Repair
Investigator(s):	Huen MSY, Yu C
Department:	School of Biomedical Sciences
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	04/2018

Project Title:	Deciphering Cancer Cell Resistance to Radiotherapy
Investigator(s):	Huen MSY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Translational and Applied Research
Start Date:	06/2018

Project Title:	A Study of DYRK1B in DNA Damage Surveillance and Repair
Investigator(s):	Huen MSY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2018

Project Title:	A Study of MIRK in DNA Damage Response Control
Investigator(s):	Huen MSY, Wong SL
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2019

Project Title:	A Study of RAD54L2 in DNA Damage Surveillance and Repair
Investigator(s):	Huen MSY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2019

Project Title:	Understanding Cancer Cell Resistance to Chemotherapeutics
Investigator(s):	Huen MSY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Translational and Applied Research
Start Date:	06/2019

List of Research Outputs

AN L., DONG C., LI J., CHEN J., Yuan J., Huang J., Chan K.M., Yu C. and Huen M.S.Y., RNF169 limits 53BP1 deposition at DSBs to stimulate single-strand annealing repair, Proc Natl Acad Sci U S A. 2018, 115(35): E8266-E8295.

CHAN L.H., Zhou L., Ng K.Y., Wong T.L., Lee T.K., Sharma R., LOONG H.C., Ching Y.P., Yuan Y.F., Xie D., Lo C.M., Man K., Artegiani B., Clevers H., Yan H.H.N., Leung S.Y., Richard S., Guan X., Huen M.S.Y. and Ma S.K.Y., Protein arginine methyltransferase PRMT6 regulates RAS/RAF binding and MEK/ERK-mediated cancer stemness activities in hepatocellular carcinoma through CRAF methylation, Cell Reports. 2018.

CHE N., Ng K.Y., Tong M., Lui Kau W.F., Huen M.S.Y., Guan X. and Ma S.K.Y., Functional and Mechanistic Characterisation of PRMT6-regulated Autophagy in Hepatocellular Carcinoma, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

CHE N., Ng K.Y., Tong M., Lui Kau W.F., Guan X., Huen M.S.Y. and Ma S.K.Y., Functional and mechanistic characterization of PRMT6-regulated autophagy in hepatocellular carcinoma, 23rd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2018.

CHE N., Ng K.Y., Tong M., Lui Kau W.F., Guan X., Huen M.S.Y. and Ma S.K.Y., Protein arginine methylation by PRMT6 regulates autophagy in hostile microenvironment of hepatocellular carcinoma tumours, 2019 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2019.

CHE N., Ng K.Y., Tong M., Lui Kau W.F., Guan X., Huen M.S.Y. and Ma S.K.Y., Protein arginine methylation by PRMT6 regulates autophagy in hostile microenvironment of hepatocellular carcinoma tumours, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

CHEN Y., LI J., CAO F., Lam J., Cheng C.C.Y., Yu C. and Huen M.S.Y., Nucleolar residence of the seckel syndrome protein TRAIP is coupled to ribosomal DNA transcription, Nucleic Acids Research. 2018, 46: 10119-10131.

DONG C., LI J. and Huen M.S.Y., DYRK1B Promotes Transcription Silencing on the Damaged Chromatin to Facilitate DSB Repair, 2019 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2019.

DONG C., WANG R., LI J., Huang J. and Huen M.S.Y., Fine-tuning of Transcriptional Activities at DSBs by the DYRK1 Kinases, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

DONG C., LI J., Huang J. and Huen M.S.Y., Fine-tuning of Transcriptional Activities at DSBs by the DYRK1B Kinase, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

DONG C., WANG R., LI J., Huang J. and Huen M.S.Y., Fine-tuning of transcriptional activities at DSBs by the DYRK1 kinases, 23rd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2018.

Sy M.H., GUO Y., Lan Y., Ng H.W.H., Miao X. and Huen M.S.Y., Stabilization Of Imprinted Retrotransposon-derived Gene Peg10 By Deubiquitinase Usp9x, 2018 Gorden Research Conference: genomic instability. 2018.

Researcher : Hung HLC

List of Research Outputs

YOU R., Ho Y.S., Hung H.L.C., LIU Y., HUANG C., Chan H.N., Ho S.L., Lui S.Y., Li H.W. and Chang R.C.C., Silica nanoparticles induce neurodegeneration-like changes in behaviour, neuropathology, and affect synapse through MAPK activation, Particle Fibre Toxicology. 2018, 15: 28.

Researcher : JIANG Q

List of Research Outputs

CHEUNG M.H., JIANG Q., Wu L.K., Shum D.K.Y. and Chan Y.S., Fluoxetine activated ependymal stem cells and induces genesis of parvalbumin-expressing interneurons in the juvenile medial vestibular nuclei, Abstracts of 14^th International Symposium on Healthy Aging. 2019, P60.

Chan Y.S., Wu L.K., JIANG Q., Ma C.W. and Shum D.K.Y., Postnatal refinement of circuit plasticity for spatial navigation, Proc. 9^th Congress of Federation of Asian-Oceanian Physiological Societies [Kobe. March 28-31, 2019]. 2019, 61.

JIANG Q. and Chan Y.S., Neurogenesis-dependent restoration of plasticity in the vestibular nucleus of young adult rats by antidepressant, Gordon Research Conference – Recent Discoveries and Technological Advances in the Study of the Nervous System during Development, Health and Diseases. 2018.

Researcher : JIANG Y

List of Research Outputs

Chan Y.S., LAM T.F., JIANG Y., Wu L.K., Ma C.W. and Wang J.J., Orexin delays activity-dependent maturation of the vestibular system in rats, Abstracts of 11^th FENS Forum of Neuroscience. 2018, 691.

Researcher : JINATA C

List of Research Outputs

FRASER L.A., Cheung Y.W., Kinghorn A.B., Guo W., SHIU C.C., JINATA C., LONG F., BHUYAN S.K., Nan L., Shum H.C. and Tanner J.A., Microfluidic Technology for Nucleic Acid Aptamer Evolution and Application, Advanced Biosystems. 2019, 3: 1900012.

Researcher : Jauch R

Project Title:	Programming functional cells for regenerative medicine with artificially evolved and enhanced transcription factors
Investigator(s):	Jauch R
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research for New Staff
Start Date:	05/2018

Project Title:	Decoding the molecular basis for the enhanced activity of artificially evolved reprogramming transcription factors
Investigator(s):	Jauch R
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2019

Project Title:	Brain organoids derived from induced neural precursor cells generated by artificially evolved transcription factors
Investigator(s):	Jauch R
Department:	School of Biomedical Sciences
Source(s) of Funding:	Germany/Hong Kong Joint Research Scheme
Start Date:	01/2019

Project Title:	Generation of induced neural stem cells for pre-clinical studies through the directed evolution of reprogramming transcription factors by cell selection and sequencing (DERBY-seq)
Investigator(s):	Jauch R
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2019

Project Title:	Germinal Stem Cell Biology; Programming cell fates with artificially evolved transcription factors
Investigator(s):	Jauch R
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2019
Completion Date:	05/2019

Project Title:	In situ sequence diversification with base editors for the directed evolution of transcription factors in mammalian cells
Investigator(s):	Jauch R
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2019

List of Research Outputs

Cheah K.S.E., Szeto Y.Y., Chu D.K.H., Au Y.K., Huang Y.H., Wynn S.L., Mak A.C.Y., Chan Y.S., Chan W.Y., Jauch R., Fritzsch B., Lovell-Badge R.H. and Sham M.H., Dual modes of cooperative repression by SOX9 and SOX10 and SOX9 transactivation of genes essential for inner ear fluid homeostasis maintain hearing., Gordon Research Conference on Neural Crest and Cranial Placodes. 2019.

Jauch R., Cell fate reprogramming through engineering of native transcription factors, Current Opinion in Genetics & Development. 2018, 52: 109-116.

Jauch R., Enhancing cell fate reprogramming with engineered proteins, Frontiers of Genome Engineering. Shanghai. 2018.

Jauch R., Enhancing cellular reprogramming by directed factor evolution, International Human Epigenome Consortium. 2018.

Jauch R., Reprogramming with re-engineered factors, invited lecture (invited by Hans Robert Schöler). 2019.

TAN D.S., Srivastava Y., WENG M., Chen Y., Wei Y. and Jauch R., Decoding the molecular basis for the functional improvement of re-engineered pluripotency reprogramming factors, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

Veerapandian V., Ackermann J.O., Srivastava Y., Malik V., WENG M., Yang X.X. and Jauch R., Directed Evolution of Reprogramming Factors by Cell Selection and Sequencing, Stem Cell Reports. 2018.

WENG M., Holzner M., TAN D.S., Srinivasan K.G., Veeramohan V., Sivastava Y., Han D., Wu G., Schöler H.R. and Jauch R., Evolving Artificially Enhanced Transcription Factors for the Generation of Induced Neuronal Stem Cells, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

WENG M., Holzner M., TAN D.S., Srinivasan K.G., Veerapandian V., Sivastara Y., Han D., Wu G., Scholer H.R. and Jauch R., Evolving Artificially Enhanced Transcription Factors for the Generation of Induced Neuronal Stem Cells, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

Researcher : Javed A

List of Research Outputs

Wlliams L.B., Javed A., Sabri A., Morgan D.J., Huff C.D., Grigg J.R., Heng X.T., Khng A.J., Hollink I.H.I.M., Morrison M.A., Owen L.A., Anderson K., Kinard K., Greenlees R., Novacic D., Nida S.H., Zein W.M., Rodgers G.M., Vitale A.T., Haider N.B., Hillmer A.M., Ng P.C., Shankaracharya , Cheng A., Zheng L., Gillies M.C., van Slegtenhorst M., van Hagen P.M., Missotten T.O.A.R., Farley G.L., Polo M., Malatack J., Curtin J., Martin F., Arbuckle S., Alexander S.I., Chircop M., Davila S., Digre K.B., Jamieson R.V. and DeAngelis M.M., ALPK1 missense pathogenic variant in five families leads to ROSAH syndrome, an ocular multisystem autosomal dominant disorder, Genetics in Medicine. 2019.

Researcher : Jia LJ

Project Title:	To investigate the role of AMP-activated protein kinase in the regulation of EBV latent and lytic infection in nasopharyngeal carcinoma
Investigator(s):	Jia LJ, Tsao GSW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	05/2018

Project Title:	Gordon Research Conference 2019 - Stem cells and cancer; Epstein-Barr virus infection confers de-differentiation properties in nasopharyngeal epithelial cells
Investigator(s):	Jia LJ
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2019
Completion Date:	03/2019

Project Title:	To explore the functional significance of retinoid signaling in EBV infection-mediated de-differentiation of nasopharyngeal epithelial cells
Investigator(s):	Jia LJ, Tsao GSW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Mini Grant
Start Date:	05/2019

List of Research Outputs

Jia L.J., Yip Y.L., LIU T., Lo K.W. and Tsao G.S.W., Epstein-Barr virus infection confers de-differentiation properties in nasopharyngeal epithelial cells, Gordon Research Conference 2019 - Stem Cells and Cancer. 2019.

Lin W., Yip Y.L., Jia L.J., Deng W., Zheng H., Dai W., Ko J.M.Y., Lo K.W., Chung G.T.Y., Yip K.Y., Lee S.D., Kwan J.S.H., Zhang J., Liu T.F., Chan Y.W., Kwong D.L.W., Lee V.H.F., Nicholls J.M., Busson P., Liu X.F., Chiang A.K.S., Hui K.F., Kwok H., Cheung S.T., Cheung Y.C., Chan C.K., Li B., Cheung A., Hau P.M., Zhou Y., Tsang C.M., Middeldorp J., Chen H., Lung M.L. and Tsao G.S.W., Establishment and characterization of new tumor xenografts and cancer cell lines from EBV-positive nasopharyngeal carcinoma, Nature Communications. 2018, 7; 9(1): 4663.

Zhang J., Jia L.J., Liu T.E.N.G.F.E.I., Yip Y.L., Tang W.C., Lin W., Deng W., Lo K.W.O.K. .W.A.I., You C., Lung M.L., Lung H.L., Tsao G.S.W., Cheung A. and Tsang C.M., mTORC2-mediated PDHE1α nuclear translocation links EBV-LMP1 reprogrammed glucose metabolism to cancer metastasis in nasopharyngeal carcinoma., Oncogene. 2019, 38(24): 4669-4684.

Researcher : Jin D

Project Title:	Mitotic checkpoint and genomic stability in ovarian cancer
Investigator(s):	Jin D
Department:	School of Biomedical Sciences
Source(s) of Funding:	National Institutes of Health, US Department of Health and Human Services - General Award
Start Date:	09/2002

Project Title:	Outstanding Researcher Award 2007-2008
Investigator(s):	Jin D
Department:	School of Biomedical Sciences
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	10/2008

Project Title:	4th Intracellular Proteolysis Meeting on Ubiquitin-proteasome System, Dynamics and Targeting REV7-mediated polyubiquitination and degradation of human REV1
Investigator(s):	Jin D
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2009

Project Title:	Knockdown of miR-BART5 in Epstein-Barr Virus-infected Cells by RNA Decoys Delivered through Novel Adenoviral Vectors: a New Paradigm for Cancer Therapy
Investigator(s):	Jin D, Kok KH, Lei T
Department:	School of Biomedical Sciences
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	01/2010

Project Title:	Knockdown of miR-BART5 in Epstein-Barr Virus-infected Cells by RNA Decoys Delivered through Novel Adenoviral Vectors: a New Paradigm for Cancer Therapy
Investigator(s):	Jin D
Department:	School of Biomedical Sciences
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	01/2010

Project Title:	Knockdown of miR-BART5 in Epstein-Barr Virus-infected Cells by RNA Decoys Delivered through Novel Adenoviral Vectors: a New Paradigm for Cancer Therapy
Investigator(s):	Jin D
Department:	School of Biomedical Sciences
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	01/2010

Project Title:	Mapping of peptide sequence in swine-origin H1N1 influenza virus hemagglutinin associated with the induction of anti-ganglioside antibodies implicated in Guillain-Barre syndrome: a pilot study
Investigator(s):	Jin D, Zheng B
Department:	School of Biomedical Sciences
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2011

Project Title:	Outstanding Research Student Supervisor Award 2013-14
Investigator(s):	Jin D
Department:	School of Biomedical Sciences
Source(s) of Funding:	Outstanding Research Student Supervisor Award
Start Date:	12/2014

Project Title:	Suppression of innate interferon production by Middle East respiratory syndrome coronavirus M protein
Investigator(s):	Jin D, Yeung ML
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2015

Project Title:	Identification and characterization of a novel transcript isoform of STING that negatively regulates innate antiviral response
Investigator(s):	Jin D, Yang W, Deng J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2016
Completion Date:	06/2019

Project Title:	Molecular Mechanism of PACT-dependent Innate Antiviral Response
Investigator(s):	Jin D, Chan CP, Sham MH, Yeung ML, Yuen KY, Zheng B, Zhou J
Department:	School of Biomedical Sciences
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2016

Project Title:	Perturbation of MAVS-dependent antiviral response by PB1-F2 protein of influenza A (H7N9) virus and implications to viral pathogenesis
Investigator(s):	Jin D, Chen H, Chan CP
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2016
Completion Date:	06/2019

Project Title:	Identification and characterization of MDM2 as an E3 ubiquitin ligase for STAT2 activated by Zika virus NS5 protein
Investigator(s):	Jin D, Yuen KS, Wang F
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2017
Completion Date:	04/2019

Project Title:	Roles of BART non-coding RNAs in Epstein-Barr virus infection and oncogenesis (CRF)
Investigator(s):	Jin D
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Funding for Strategic Interdisciplinary Research Scheme
Start Date:	06/2017

Project Title:	Roles of the chromatin architectural protein CTCF in hepatitis B virus transcription
Investigator(s):	Jin D, Kong KY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2017

Project Title:	Regulatory roles of WD40 repeat-containing protein 5 (WDR5) in hepatitis B virus transcription
Investigator(s):	Jin D, Kong KY, Chan CP
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2018

Project Title:	Suppression of type I and type II interferon production and signalling by Epstein-Barr virus BGLF2 protein
Investigator(s):	Jin D, Yuen KS, Botelho MG
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	08/2018

Project Title:	Precision genome engineering by CRISPR: applications in biology and medicine
Investigator(s):	Jin D
Department:	School of Biomedical Sciences
Source(s) of Funding:	Croucher Summer Courses
Start Date:	08/2018

Project Title:	High-throughput genome-wide genetic screening using CRISPR/Cas9
Investigator(s):	Jin D, Kok KH, Yeung ML, Liu P
Department:	School of Biomedical Sciences
Source(s) of Funding:	Platform Technology Funding
Start Date:	04/2019

Project Title:	19th International Conference on Human Retrovirology - HTLV2019; Anti-HTLV-1 activity of SAMHD1 in resting T cells
Investigator(s):	Jin D
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2019
Completion Date:	04/2019

Project Title:	Activation of AIM2 inflamamsome by Epstein-Barr virus BPLF1 deubiquitinase
Investigator(s):	Jin D, Yuen KS
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2019

List of Research Outputs

. S., Yuen K.S., CHAUDHARY V., Botelho M.G. and Jin D., Dysregulation of innate interferon signaling by Epstein-Barr virus tegument protein BGLF2, IMMUNOLOGY 2019: Annual Meeting of The American Association of Immunologists, San Diego, California, USA. 2019.

. S., Botelho M.G. and Jin D., Epstein–Barr Virus and Innate Immunity: Friends or Foes?, Microorganisms. 2018, 7: 183.

CHEUNG P.H.H. and Jin D., Influenza A virus PB1-F2 protein suppresses IL-1β production from human macrophages by enhancing MAVS degradation, American Society for Virology Travel Award. 2018.

CHEUNG P.H.H., Fung S.Y., Yuen K.Y., Chen H. and Jin D., Influenza A virus PB1-F2 protein suppresses IL-1β production from human macrophages by enhancing MAVS degradation, The American Society for Virology 37th Annual Meeting, University of Maryland, College Park, Maryland, USA, July 14-18, 2018.. 2018.

Chan C.P., Yuen C.K.J., CHEUNG P.H.H., Fung S.Y., Lui P.Y., Chen H., Kok K.H. and Jin D., Antiviral activity of double-stranded RNA–binding protein PACT against influenza A virus mediated via suppression of viral RNA polymerase, The FASEB Journal. 2018, 32: 4380-4393.

Chu H., Chan C.M., Zhang X., Wang Y., Yuan S., Zhou J., Au Yeung K.H.R., Sze K.H., Yang D., Shuai H.V., Hou Y., Li C., Zhao X., Poon K.M., Leung A.S.P., Yeung M.L., Yan J., Lu G., Jin D., Gao G.F., Chan J.F.W. and Yuen K.Y., Middle East respiratory syndrome coronavirus and bat coronavirus HKU9 both can utilize GRP78 for attachment onto host cells, Journal of Biological Chemistry. 2018, 293: 11709-11726.

Fung S.Y., Chan C.P., Zhu L., Yuen K.Y., Woo P.C.Y., Cai Z. and Jin D., Middle East respiratory syndrome coronavirus ORF4b protein targets cGAS-STING pathway of nucleic acid sensing., Keystone Symposium on “Framing the Response to Emerging Virus Infections“, Pokfulam, Hong Kong. 2018.

Fung S.Y., Cheung P.H.H., Chan C.P. and Jin D., Perturbation of innate DNA sensing by human RNA viruses., The 7th Cross Straight Immunology Conference. 2018.

Jin D., Chan C.P., Fung S.Y., Yuen K.S. and Chan C.P., Anti-HTLV-1 activity of SAMHD1 in resting T cells, HTLV 2019: 19th International Conference on Human Retrovirology, Lima, Peru. 2019.

Jin D., CHENG T.F., HO T.H. and Yuen K.S., Caspase 3 activation facilitates Epstein-Barr virus lytic replication in epithelial cells, 2018 International Conference on EBV & KSHV. University of Wisconsin – Madison, Wisconsin, USA, July 28 to August 1, 2018.. 2018.

Jin D., Editorial Board Member, Journal of Virology. 2019.

Jin D., Excellent Research Award, Health Symposium 2019, Food and Health Bureau of Hong Kong. 2019.

Jin D., International Collaborative Partner, Universiti Tunku Abdul Rahman Global Research Network, Malaysia. 2018.

Jin D., CHENG T., HUNG T.N., Kong K.Y. and Chan C.P., Suppression of hepatitis B virus transcription by RFWD2 ubiquitin ligase, 2018 International HBV Meeting: The Molecular Biology of Hepatitis B Viruses. Palazzo dei Congressi, Piazza Vittorio Emanuele Taormina (Messina), Italy, October 3-6, 2018.. 2018.

Kong K.Y., CHENG T. and Jin D., The chromatin architectural protein CTCF binds to HBV cccDNA and promotes its transcription, 2018 International HBV Meeting: The Molecular Biology of Hepatitis B Viruses. Palazzo dei Congressi, Piazza Vittorio Emanuele Taormina (Messina), Italy, October 3-6, 2018.. 2018.

Kong K.Y. and Jin D., Travel Award, 2018 International HBV Meeting. 2018.

LUI W.Y., Yuen K.S. and Jin D., Suppression of cGAS-STING pathway for type I interferon production pathway by Epstein-Barr virus-encoded BPLF1 protein, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

LUI W.Y., Yuen K.S. and Jin D., Suppression of cGAS-STING- and RIG-I-MAVS-mediated innate immune responses by Epstein-Barr virus-encoded tegument protein BPLF1 through de-ubiquitination, IMMUNOLOGY 2019: Annual Meeting of The American Association of Immunologists, San Diego, California, USA. 2019.

Leung K.C., Luk H.M., Tang H.M.V., Gao W., MAK C.C.Y., YU H.C., Wong W.L., Chu W.Y., Yang W., Wong W.H.S., Ma C.H., Leung A.Y.H., Jin D., Chan Y.K., Allanson J., Lo F.M.I. and Chung B.H.Y., Integrating Functional Analysis in the Next-Generation Sequencing Diagnostic Pipeline of RASopathies, Scientific Reports. 2018, 8: 2421.

WONG L.Y.R. and Jin D., Middle-East respiratory syndrome coronavirus ORF8b protein suppresses type I interferon production by interacting with HSP70, American Society for Virology Travel Award. 2018.

WONG L.Y.R., Lui P.Y., Siu K.L., Yeung M.L., Yuen K.S., Fung S.Y., Chan C.P., Woo P.C.Y., Yuen K.Y. and Jin D., Middle-East respiratory syndrome coronavirus ORF8b protein suppresses type I interferon production by interacting with HSP70, The American Society for Virology 37th Annual Meeting, University of Maryland, College Park, Maryland, USA, July 14-18, 2018.. 2018.

WONG L.Y.R., Ye Z., Lui P.Y., Siu K.L., Yeung M.L., Yuen K.S., Fung S.Y., Chan C.P., Cai Z., Woo P.C.Y., Yuen K.Y. and Jin D., Suppression of type I interferon production by Middle East respiratory syndrome coronavirus ORF8b accessory protein through interaction with HSP70 chaperone, Keystone Symposium on “Framing the Response to Emerging Virus Infections”, Pokfulam, Hong Kong. 2018.

Wang F., Ye Z., Deng J., Siu K.L., Gao W., Chaudhary V., Cheng Y., Fung S.Y., Yuen K.S., Ho T.H., Chan C.P., Zhang Y., Kok K.H., Yang W., Chan C.P. and Jin D., Inhibition of AIM2 inflammasome activation by a novel transcript isoform of IFI16. , EMBO reports. 2018.

Wang F., Ye Z., Chan C.P. and Jin D., Putting a brake on inflammasome activation by reprogramming transcription from an alternative promoter: IFI16 as an example, 11th International Singapore Symposium of Immunology, Singapore. 2019.

Ye Z., CHAUDHARY V., Chan J.F.W. and Jin D., Activation of interferon-γ signaling by SFTS virus NSs protein, Keystone Symposium on “Framing the Response to Emerging Virus Infections, Pokfulam, Hong Kong. 2018.

Yeung M.L., JIA L., Yip C.Y., Chan J.F.W., Teng L.L., Chan K.H., Cai J., ZHANG C., Zhang J., Wong L.W.M., Kok K.H., Lau S.K.P., Woo P.C.Y., Lo J.Y.C., Jin D., Shih S.R. and Yuen K.Y., Human tryptophanyl-tRNA synthetase is an IFN-γ–inducible entry factor for Enterovirus, Journal of Clinical Investigation. 2018, 128: 5163-5177.

Yuan S., Chan J.F.W., Ye Z.W., Wen L., Tsang T.G.W., Cao J., Huang J., Chan C.Y.C., Chik K.K.H., Choi G.K.Y., Cai J., Yin F., Chu H., Liang M., Jin D. and Yuen K.Y., Screening of an FDA-Approved Drug Library with a Two-Tier System Identifies an Entry Inhibitor of Severe Fever with Thrombocytopenia Syndrome Virus, Viruses. 2019, 11: 385.

Yuen K.S., LUI W.Y. and Jin D., Inflammasome activation by Epstein-Barr virus deubiquitinase BPLF1 in nasopharyngeal carcinoma cells, 2018 International Conference on EBV & KSHV. University of Wisconsin – Madison, Wisconsin, USA, July 28 to August 1, 2018.

ZHU Z., Chu H., WEN L., Yuan S., CHIK K.K.H., YUEN T.T., Yip C.Y., WANG D., Zhou J., Yin F., Jin D., Kok K.H., Yuen K.Y. and Chan J.F.W., Targeting SUMO Modification of the Non-Structural Protein 5 of Zika Virus as a Host-Targeting Antiviral Strategy, International Journal of Molecular Sciences. 2019, 20: 392.

Researcher : KHONG ML

List of Research Outputs

KHONG M.L., Polyphosphate as a Fundamental Molecule in Human Osteoblasts (PhD Thesis), The University of Hong Kong. 2018.

KHONG M.L., Li L., Solesio M.E.T., Pavlov E. and Tanner J.A., Polyphosphate: a fundamental regulator of protein folding in human osteoblasts, The 43rd FEBS Congress, Prague, Czech Republic. 2018.

Khong M.L. and Tanner J.A., Designing and implementing a student-led collaborative biomedical project as a transdisciplinary course, Frontiers in Medical and Health Sciences Education – Learning in Alliance: Inter-professional Health Education and Practice, The University of Hong Kong, Hong Kong. 2018.

Khong M.L. and Tanner J.A., Developing the research-teaching nexus within a transdisciplinary open platform Common Core Course, Co-constructing Excellence: Recognising, Scaffolding and Building Excellence in University Learning and Teaching, The University of Hong Kong, Hong Kong. 2018.

Li L., KHONG M.L., Lui E.L.H., Mebarek S., Magne D., Buchet R. and Tanner J.A., Long-chain polyphosphate in osteoblast matrix vesicles: Enrichment and inhibition of mineralization, Biochimica et Biophysica Acta (BBA) - General Subjects. 2019, 1863: 199-209.

Researcher : KWAN PY

List of Research Outputs

Chan Y.S., KWAN P.Y., Tam K.W., Ma C.W., Wu L.K. and Shum D.K.Y., Perineuronal net and semaphorin regulate developmental plasticity of the central vestibular circuitry for sensori-motor function, Abstracts of 15^th Conference of Asia-Pacific Society for Neurochemistry. 2018, 82.

KWAN P.Y., Shum D.K.Y. and Chan Y.S., Perineuronal chondroitin sulfates reinforce inhibitory GABAergic transmission in the maturation of sensori-motor function, Matrix Biology Europe 2018. [Manchester, UK. July 21-24, 2018]. 2018.

Kwan P.Y., Shum D.K.Y. and Chan Y.S., Perineuronal Chondroitin Sulfates Disruption Interferes Excitation/Inhibition Balance in Developing Vestibular Circuitry, the 14th International Symposium on Healthy Aging . 2019.

Kwan P.Y., Shum D.K.Y. and Chan Y.S., Perineuronal chondroitin sulfates reinforce inhibitory GABAergic transmission in the maturation of sensori-motor function, Matrix Biology Europe 2018.

Ma C.W., Kwan P.Y., Wu L.K., Shum D.K.Y. and Chan Y.S., Regulatory roles of perineuronal nets and semaphorin 3A in the postnatal maturation of the central vestibular circuitry for graviceptive reflex, Brain Structure and Function. 2019, 224: 613-626.

Shum D.K.Y., KWAN P.Y., Ho S.N.S., Hau W.F., Tam K.W., Wu L.K., Ma C.W. and Chan Y.S., Dynamics of perineuronal net-associated plastic factors after sensory loss, Abstracts of 15^th Meeting of Asian-Pacific Society for Neurochemistry [Macau. Aug. 27-29, 2018]. 2018, 80.

Shum D.K.Y., KWAN P.Y., HAU W.F., Tam K.W., Wu L.K., Ma C.W. and Chan Y.S., Dynamics of perineuronal net-associated plastic factors after sensory loss, Abstracts of 15^th Meeting of Asian-Pacific Society for Neurochemistry, 80. [Macau. Aug. 27-29, 2018]. 2018, 80.

Researcher : KWON YJ

List of Research Outputs

KWON Y.J., Contribution of Pax1 to pathogenesis of adolescent idiopathic scoliosis (MPhil Thesis), The University of Hong Kong. 2018.

Researcher : Keung WWY

List of Research Outputs

Geng L., Kong M.C.W., WONG O.T., Shum A.M.Y., Chow M.Z.Y., Che H., Zhang C.Z., Yau K.L., Chan C.W.Y., Keung W.W.Y. and Li R.A., Probing flecainide block of INa using human pluripotent stem cell-derived ventricular cardiomyocytes adapted to automated patch-clamping and 2D monolayers, Toxicology Letters. 2018, 294: 61-72.

Researcher : Khong ML

List of Research Outputs

KHONG M.L., Polyphosphate as a Fundamental Molecule in Human Osteoblasts (PhD Thesis), The University of Hong Kong. 2018.

Researcher : Kinghorn AB

Project Title:	Aptamers in Bordeaux 2017; Aptamer affinity maturation by resampling of aptamer libraries based on an aptamer family consensus motif
Investigator(s):	Kinghorn AB
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2017

List of Research Outputs

Dhillo W.S., LIANG S., Kinghorn A.B., Voliotis M., Prague M.K., Veldhuis J.D., SHIU C.C., Tsaneva-Atanasova K., McArdle C.A., Li R.H.W., Cass A.E.G. and Tanner J.A., Measuring LH Pulsatility in Patients with Reproductive Disorders using a Novel Robotic Aptamer-Enabled Electrochemical Reader (RAPTER), Journal of the Endocrine Society, 3, Supplement 1, SAT-LB040, ENDO 2019, New Orleans, USA. 2019.

FRASER L.A., Cheung Y.W., Kinghorn A.B., Guo W., SHIU C.C., JINATA C., LONG F., BHUYAN S.K., Nan L., Shum H.C. and Tanner J.A., Microfluidic Technology for Nucleic Acid Aptamer Evolution and Application, Advanced Biosystems. 2019, 3: 1900012.

Fraser L.A., Kinghorn A.B., Dirkzwager R.M., Liang S., Cheung Y.W., Lim B., Shiu C.C., Tang S.L.M., Andrew D., Manitta J., Richards J.S. and Tanner J.A., A portable microfluidic Aptamer-Tethered Enzyme Capture (APTEC) biosensor for malaria diagnosis, Biosensors and Bioelectronics. 2018, 100(Supplement C): 591-596.

Guo W., Tang M., Kinghorn A.B., Tanner J.A. and Shum H.C., Droplet Microfluidics for RNA fluorogenic aptamer screening, MNMC EMBS Micro and Nanotechnology in Medicine Conference, Koloa, Hawaii, USA. 2018.

LIANG S., Kinghorn A.B., Voliotis M., Prague J.K., Veldhuis J.D., Tsaneva-Atanasova K., McArdle C.A., Li R.H.W., Cass A.E.G., Dhillo W.S. and Tanner J.A., Measuring luteinising hormone pulsatility with a robotic aptamer-enabled electrochemical reader, Nature Communications. 2019, 10: 852.

LIANG S., Kinghorn A.B., Voliotis M., Prague M.K., Veldhuis J.D., SHIU C.C., Tsaneva-Atanasova K., McArdle C.A., Li R.H.W., Cass A.E.G., Dhillo W.S. and Tanner J.A., Robotic aptamer-enabled electrochemical reader (RAPTER) – Diagnosing reproductive disorders from the laboratory to the clinic, Aptamers 2019, 6th Oxford Symposium on Aptamers, Oxford University, United Kingdom. 2019.

SHIU C.C., Kinghorn A.B., Sakai Y., Cheung Y.W., Heddle J.G. and Tanner J.A., Three S’s for aptamer-mediated control of DNA nanostructure dynamics: shape, self-complementarity and spatial flexibility, Chembiochem. 2018, 19(18): 1900.

Tang S.L.M., Shiu C.C., Godonoga M., Cheung Y.W., Liang S., Dirkzwager R.M., Kinghorn A.B., Fraser L.A., Heddle J.G. and Tanner J.A., An aptamer-enabled DNA nanobox for protein sensing, Nanomedicine: Nanotechnology, Biology and Medicine. 2018, 14(4): 1161-1168.

Tanner J.A., Kinghorn A.B. and Cheung Y.W., Co-Editor, In: Julian Alexander Tanner, Andrew Brian Kinghorn and Yee-Wai Cheung, Aptamers. MDPI Books, 2018.

Researcher : Koh J

List of Research Outputs

Koh J., Lim W.L., Neoh J., Hescham S., Blokland A., Chan Y.S., Temel Y. and Lim L.W., Brain pacemaker and memory enhancement: Investigation of molecular mechanisms in the aged brain., International Alzheimer’s Disease Conference. Hong Kong.. 2018.

Koh J., Lim W.L., Zhang C.F., Heng B.C., Neoh J., Hescham S.A., Blokland A., Wu E.X., Chan Y.S., Temel Y. and Lim L.W., Pacemaker in the aged brain: From molecular profiling to memory enhancement, Abstracts of 14^th International Symposium on Healthy Aging –Embrace the Golden Years [HK. March 16-17, 2019]. 2019, P50.

Researcher : Kong KY

List of Research Outputs

Jin D., CHENG T., HUNG T.N., Kong K.Y. and Chan C.P., Suppression of hepatitis B virus transcription by RFWD2 ubiquitin ligase, 2018 International HBV Meeting: The Molecular Biology of Hepatitis B Viruses. Palazzo dei Congressi, Piazza Vittorio Emanuele Taormina (Messina), Italy, October 3-6, 2018.. 2018.

Kong K.Y., CHENG T. and Jin D., The chromatin architectural protein CTCF binds to HBV cccDNA and promotes its transcription, 2018 International HBV Meeting: The Molecular Biology of Hepatitis B Viruses. Palazzo dei Congressi, Piazza Vittorio Emanuele Taormina (Messina), Italy, October 3-6, 2018.. 2018.

Kong K.Y. and Jin D., Travel Award, 2018 International HBV Meeting. 2018.

Researcher : Kudelko MA

Project Title:	Cartilage Development and Regeneration and Their Implications in Disease Therapies; Label-Free Proteomic Comparison of Murine Intervertebral Disc Across Gender, Level and Structure
Investigator(s):	Kudelko MA
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2019
Completion Date:	03/2019

Researcher : Kwan PY

Project Title:	Matrix Biology Europe 2018; Perineuronal chondroitin sulfates reinforce inhibitory GABAergic transmission in the maturation of sensori-motor function
Investigator(s):	Kwan PY
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2018
Completion Date:	07/2018

List of Research Outputs

Kwan P.Y., Shum D.K.Y. and Chan Y.S., Perineuronal chondroitin sulfates reinforce inhibitory GABAergic transmission in the maturation of sensori-motor function, Matrix Biology Europe 2018.

Researcher : Kwok LF

List of Research Outputs

Wong M.C., Tam K.W., Kwok L.F., Chan Y.S., Shea G.K.H. and Shum D.K.Y., Genipin-treated chitosan nanofibers to assist post-traumatic axon regrowth and remyelination in the peripheral nervous system, Abstracts of 14^th International Symposium on Healthy Aging. 2019, P12.

Researcher : Kwon YJS

List of Research Outputs

Vimalagopalan D., Kwon Y.J.S., Chan W.C.W. and Chan D., Role of Pax1 in the etiology of adolescent idiopathic scoliosis, 23rd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2018.

Researcher : LAI SLM

List of Research Outputs

LAI S.L.M., Lee K. and Chang R.C.C., Visualization of neural pathways in Parkinson’s disease by transparent brain and neural tracing, The 14th International Symposium on Healthy Aging. 2019, 64.

Researcher : LAM TF

List of Research Outputs

Chan Y.S., LAM T.F., JIANG Y., Wu L.K., Ma C.W. and Wang J.J., Orexin delays activity-dependent maturation of the vestibular system in rats, Abstracts of 11^th FENS Forum of Neuroscience. 2018, 691.

Researcher : LAM Y

List of Research Outputs

LAM Y., Dynamics of Progenitor Cells in the Formation and Repair of Synovial Joints (PhD Thesis), The University of Hong Kong. 2019.

Researcher : LEUNG OW

List of Research Outputs

LEUNG O.W., Molecular Basis and Cellular Events of Brachydactyly Type A1 Pathogensis (MPhil Thesis), The University of Hong Kong. 2019.

Researcher : LI C

List of Research Outputs

LI C., Huang L., Sun W., Chen Y., He M.L., Yue J. and Ballard H.J., Saikosaponin D inhibits autophagy to suppress enterovirus A71 infection, Signal Transduction and Targeted Therapy. Nature, 2019, 4: Article 4.

Researcher : LI H

List of Research Outputs

YAO M., Sun H., Yuan Q., LI N., LI H., Tang Y., Leung G.K.K. and Wu W., Targeting proteoglycan receptor PTPσ restores sensory function after spinal cord dorsal root injury by activation of Erks/CREB signaling pathway, Neuropharmacology. 2018, 144: 208-218.

Researcher : LI J

List of Research Outputs

AN L., DONG C., LI J., CHEN J., Yuan J., Huang J., Chan K.M., Yu C. and Huen M.S.Y., RNF169 limits 53BP1 deposition at DSBs to stimulate single-strand annealing repair, Proc Natl Acad Sci U S A. 2018, 115(35): E8266-E8295.

CHEN Y., LI J., CAO F., Lam J., Cheng C.C.Y., Yu C. and Huen M.S.Y., Nucleolar residence of the seckel syndrome protein TRAIP is coupled to ribosomal DNA transcription, Nucleic Acids Research. 2018, 46: 10119-10131.

DONG C., LI J. and Huen M.S.Y., DYRK1B Promotes Transcription Silencing on the Damaged Chromatin to Facilitate DSB Repair, 2019 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2019.

DONG C., WANG R., LI J., Huang J. and Huen M.S.Y., Fine-tuning of Transcriptional Activities at DSBs by the DYRK1 Kinases, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

DONG C., LI J., Huang J. and Huen M.S.Y., Fine-tuning of Transcriptional Activities at DSBs by the DYRK1B Kinase, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

DONG C., WANG R., LI J., Huang J. and Huen M.S.Y., Fine-tuning of transcriptional activities at DSBs by the DYRK1 kinases, 23rd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2018.

Wang B., Bao S., ZHANG Z., ZHOU X., WANG J., Fan Y., Zhang Y., Li Y., Chen L.P., Jia Y., LI J., Li M., Zheng W., Mu N., Yang W., Yu Z., Lau D.S.S., Wong S.M., ZHANG Y., Kwan J.S.K., Mak H.K.F., Ambalavanan A., Zhou S., Cai W., Zheng J., Huang S., Rouleau G.A., Yang W., Rogaeva E., Ma X., St George-Hyslop P., Chu L.W. and Song Y., A rare variant in MLKL confers susceptibility to ApoE ɛ4-negative Alzheimer's disease in Hong Kong Chinese population, Neurobiol Aging. 2018, 68:160: e1-e7.

Researcher : LI J

List of Research Outputs

Researcher : LI TW

List of Research Outputs

LI T.W., Functional characterization, clinical relevance and therapeutic implication of follistatin-like 1 (FSTL1) in hepatocellular carcinoma (MPhil Thesis), The University of Hong Kong. 2018.

Researcher : LI X

List of Research Outputs

LI X., Ng A.S., Mak C.Y., Zhou Y., Cheung A.N.Y. and Cheung W.T.L., Characterization of PIK3R1 driver aberrations reveals novel therapeutic responses in gynecological cancers., 14th International Symposium on Healthy Aging “Embrace the Golden Years”. 2019.

LI X., Mak C.Y., Zhou Y., Cheung A.N.Y. and Cheung W.T.L., Decreased PIK3R1 expression activates AKT and STAT3 in ovarian cancer, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

LI X., Mak C.Y., Zhou Y., Chao W., Wong E.S.Y., Sharma R., Lu Y., Cheung A.N.Y., Mills G.B. and Cheung W.T.L., Deregulated Gab2 phosphorylation mediates aberrant AKT and STAT3 signaling upon PIK3R1 loss in ovarian cancer, Nature Communications. 2019, 10: 716.

LI X., Mak C.Y., Cheung A.N.Y., Mills G.B. and Cheung W.T.L., p85α alters Gab2 phosphorylation profile in ovarian cancer, American Association of Cancer Research (AACR) Annual Meeting 2019.

Researcher : LIANG S

List of Research Outputs

Dhillo W.S., LIANG S., Kinghorn A.B., Voliotis M., Prague M.K., Veldhuis J.D., SHIU C.C., Tsaneva-Atanasova K., McArdle C.A., Li R.H.W., Cass A.E.G. and Tanner J.A., Measuring LH Pulsatility in Patients with Reproductive Disorders using a Novel Robotic Aptamer-Enabled Electrochemical Reader (RAPTER), Journal of the Endocrine Society, 3, Supplement 1, SAT-LB040, ENDO 2019, New Orleans, USA. 2019.

Fraser L.A., Kinghorn A.B., Dirkzwager R.M., Liang S., Cheung Y.W., Lim B., Shiu C.C., Tang S.L.M., Andrew D., Manitta J., Richards J.S. and Tanner J.A., A portable microfluidic Aptamer-Tethered Enzyme Capture (APTEC) biosensor for malaria diagnosis, Biosensors and Bioelectronics. 2018, 100(Supplement C): 591-596.

LIANG S., An aptamer-based sensing platform for luteinising hormone pulsatility measurement (PhD Thesis), The University of Hong Kong. 2018.

LIANG S., Kinghorn A.B., Voliotis M., Prague J.K., Veldhuis J.D., Tsaneva-Atanasova K., McArdle C.A., Li R.H.W., Cass A.E.G., Dhillo W.S. and Tanner J.A., Measuring luteinising hormone pulsatility with a robotic aptamer-enabled electrochemical reader, Nature Communications. 2019, 10: 852.

LIANG S., Kinghorn A.B., Voliotis M., Prague M.K., Veldhuis J.D., SHIU C.C., Tsaneva-Atanasova K., McArdle C.A., Li R.H.W., Cass A.E.G., Dhillo W.S. and Tanner J.A., Robotic aptamer-enabled electrochemical reader (RAPTER) – Diagnosing reproductive disorders from the laboratory to the clinic, Aptamers 2019, 6th Oxford Symposium on Aptamers, Oxford University, United Kingdom. 2019.

Tang S.L.M., Shiu C.C., Godonoga M., Cheung Y.W., Liang S., Dirkzwager R.M., Kinghorn A.B., Fraser L.A., Heddle J.G. and Tanner J.A., An aptamer-enabled DNA nanobox for protein sensing, Nanomedicine: Nanotechnology, Biology and Medicine. 2018, 14(4): 1161-1168.

Researcher : LIN L

List of Research Outputs

LIN L., LYU Q., Shen X., ZHAO J., Chai A. and Lai K.O., The epilepsy gene tbc1d24 encodes a novel synaptic protein that is required for the maintenance of excitatory synapses in hippocampal neuron, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

LIN L., LYU Q., Shen X., ZHAO J., Chai A. and Lai K.O., The epilepsy gene tbc1d24 encodes a novel synaptic protein that is required for the maintenance of excitatory synapses in neuron, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

LIN L., The epilepsy gene TBCID24 encodes a novel synaptic protein that is required for the maintenance of excitatory synapses in hippocampal neuron (PhD Thesis) , The University of Hong Kong. 2019.

Shen X., LIN L., LYU Q., ZHAO J., Chai A., Lai C.S., Chan Y.S. and Lai K.O., Impaired cognitive function and increased seizure susceptibility in mice depleted of the signalling protein TBC1D24, Abstracts of 14th International Symposium on Healthy Aging –Embrace the Golden Years : [HK. March 16-17, 2019]. 2019, P15.

Researcher : LIN Q

List of Research Outputs

ARYA S., LIN Q. and Huang J., mRNA therapeutics: a different vision, 23rd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2018.

ARYA S., Lin Q., Zhou N. and Huang J., mRNA therapeutics, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

Researcher : LIN X

List of Research Outputs

LIN X., FENG D., DONG R., Lai K.O. and Gao B., Identification and characterization of the interactome of core Planar cell polarity (PCP) protein Vangl2, 2019 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2019.

Researcher : LIU KL

List of Research Outputs

LIU K.L., Chau T.W., Lim E.J., Ahmed I., Kalaitzakis M.R., Graeber M.B. and Gentleman S.M., Hippocampal CA2 Lewy pathology is associated with cholinergic degeneration in Parkinson’s disease with cognitive decline, Acta Neuropathol. Comm.. 2019, 7: 61.

LIU K.L., Lim E.J., Ahmed I., Chang R.C.C., Pearce R.K.B. and Gentleman S.M., Revisiting the human cholinergic nucleus of the diagonal band of Broca, Neuropathol. Appl. Neurobiol.. 2018, 44: 647-662.

Lai H.M., LIU K.L., Ng H.H.M., Goldfinger M.H., Chau T.W., DeFelice J., Tilley B.S., Wong W.M., Wu W. and Gentleman S.M., Next generation histology methods for three-dimensional imaging of fresh and archival human brain tissues, Nature Communications. 2018, 9.

Researcher : LIU M

List of Research Outputs

LIU M., Cheung Y.W., Yu Y.Y., Choi N.T.V. and Tanner J.A., Development of Nucleic Acid Aptamer-functionalized Regenerative Medicine for Regenerative Applications, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

LIU M., YU Y., Cheung Y.W., Choi N.T.V. and Tanner J.A., Development of aptamer inhibitors against ADAMTS-5 for osteoarthritis disease, Aptamers 2019, 6th Oxford Symposium on Aptamers, Oxford University, United Kingdom. 2019.

Researcher : LIU R

List of Research Outputs

BADEA S.-.R., RONG L., LIU R., SUN H., WU W. and Huang J., Overcoming CSPG-mediated inhibition by targeting PTPσ in experimental models of multiple sclerosis, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

LIU R., Yue J., Yang S. and Wu W., Investigating the effect of a small molecular compound YS620 in the treatment of Alzheimer's Disease, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

Liu R., Yue J.B., Yang S.Y., Wu W. and Song Y., The effect of a small molecular compound in the treatment of Alzheimer’s Disease, 2019 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2019.

Researcher : LIU T

List of Research Outputs

Jia L.J., Yip Y.L., LIU T., Lo K.W. and Tsao G.S.W., Epstein-Barr virus infection confers de-differentiation properties in nasopharyngeal epithelial cells, Gordon Research Conference 2019 - Stem Cells and Cancer. 2019.

Pang P.S., LIU T., Lin W., Tsang C.M., Yip Y.L., Zhou Y.L., Guan X., Chan R.C.K., Tsao G.S.W. and Deng W., Defining early events of Epstein–Barr virus (EBV) infection in immortalized nasopharyngeal epithelial cells using cell-free EBV infection, Journal of General Virology. 2019, 100: 999-1012.

Researcher : LO HYL

List of Research Outputs

LO H.Y.L., DONG R., LYU Q. and Lai K.O., The protein arginine methyltransferase PRMT8 regulates actin polymerization that is crucial for dendritic spine maturation and social behavior, 13th Annual Canadian Neuroscience Meeting. 2019.

LO H.Y.L., DONG R., LYU Q. and Lai K.O., The protein arginine methyltransferase PRMT8 regulates dendritic spine maturation and localization of excitatory synapses, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

LO H.Y.L., DONG R., LYU Q. and Lai K.O., The protein arginine methyltransferase PRMT8 regulates dendritic spine maturation and localization of excitatory synapses, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

Researcher : LONG F

List of Research Outputs

FRASER L.A., Cheung Y.W., Kinghorn A.B., Guo W., SHIU C.C., JINATA C., LONG F., BHUYAN S.K., Nan L., Shum H.C. and Tanner J.A., Microfluidic Technology for Nucleic Acid Aptamer Evolution and Application, Advanced Biosystems. 2019, 3: 1900012.

LONG F., ISM1 in mammary gland morphogenesis and malignant transformation (PhD Thesis), The University of Hong Kong. 2019.

Researcher : LOONG HC

List of Research Outputs

CHAN L.H., Zhou L., Ng K.Y., Wong T.L., Lee T.K., Sharma R., LOONG H.C., Ching Y.P., Yuan Y.F., Xie D., Lo C.M., Man K., Artegiani B., Clevers H., Yan H.H.N., Leung S.Y., Richard S., Guan X., Huen M.S.Y. and Ma S.K.Y., Protein arginine methyltransferase PRMT6 regulates RAS/RAF binding and MEK/ERK-mediated cancer stemness activities in hepatocellular carcinoma through CRAF methylation, Cell Reports. 2018.

LOONG H.C., Wong T.L., Tong M., Sharma R., Zhou L., Ng K.Y., Li C.H.S. and Ma S.K.Y., Fucosyltransferase 1 (FUT1) sustains cancer stemness phenotype in hepatocellular carcinoma (HCC) under glucose restriction stress, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

LOONG H.C., Wong T.L., Sharma R., Zhou L., Ng K.Y., Li S. and Ma S.K.Y., Fucosyltransferase 1 (FUT1) sustains cancer stemness phenotype in hepatocellular carcinoma (HCC) under glucose restriction stress, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

LOONG H.C., Tong M., Wong T.L., Li S. and Ma S.K.Y., Fucosyltransferase 1 (FUT1) sustains cancer stemness phenotype in hepatocellular carcinoma under glucose restriction stress, 23rd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2018.

Researcher : LUI J

List of Research Outputs

LUI J., Li Z., SIT H.M., Zhang M. and Sham M.H., Dysregulation of Cel-Cell Interaction Genes in Sox10 Mutant Enteric Neural Crest Cells, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

LUI J., Li Z. and Sham M.H., The Role of ephrin-A1/EphA4 signaling in Enteric Neural Crest Cell Migration, 2019 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2019.

Researcher : LUI WY

List of Research Outputs

LUI W.Y., Yuen K.S. and Jin D., Suppression of cGAS-STING pathway for type I interferon production pathway by Epstein-Barr virus-encoded BPLF1 protein, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

LUI W.Y., Yuen K.S. and Jin D., Suppression of cGAS-STING- and RIG-I-MAVS-mediated innate immune responses by Epstein-Barr virus-encoded tegument protein BPLF1 through de-ubiquitination, IMMUNOLOGY 2019: Annual Meeting of The American Association of Immunologists, San Diego, California, USA. 2019.

Yuen K.S., LUI W.Y. and Jin D., Inflammasome activation by Epstein-Barr virus deubiquitinase BPLF1 in nasopharyngeal carcinoma cells, 2018 International Conference on EBV & KSHV. University of Wisconsin – Madison, Wisconsin, USA, July 28 to August 1, 2018.

Researcher : LUK TCS

List of Research Outputs

LUK T.C.S., Role of REX1 Down-Regulation in Promoting Cancer and Stemness Properties in Hepatocellular Carcinoma (PhD Thesis), The University of Hong Kong. 2018.

Researcher : LYU Q

List of Research Outputs

LIN L., LYU Q., Shen X., ZHAO J., Chai A. and Lai K.O., The epilepsy gene tbc1d24 encodes a novel synaptic protein that is required for the maintenance of excitatory synapses in hippocampal neuron, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

LIN L., LYU Q., Shen X., ZHAO J., Chai A. and Lai K.O., The epilepsy gene tbc1d24 encodes a novel synaptic protein that is required for the maintenance of excitatory synapses in neuron, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

LO H.Y.L., DONG R., LYU Q. and Lai K.O., The protein arginine methyltransferase PRMT8 regulates actin polymerization that is crucial for dendritic spine maturation and social behavior, 13th Annual Canadian Neuroscience Meeting. 2019.

LO H.Y.L., DONG R., LYU Q. and Lai K.O., The protein arginine methyltransferase PRMT8 regulates dendritic spine maturation and localization of excitatory synapses, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

LO H.Y.L., DONG R., LYU Q. and Lai K.O., The protein arginine methyltransferase PRMT8 regulates dendritic spine maturation and localization of excitatory synapses, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

LYU Q., FAN R., Tsui Y.P., Chan Y.S., Shum D.K.Y. and Lai K.O., ) The use of genome-editing to study the pathophysiological mechanism of brain disorders in human induced pluripotent stem cell (iPSC), Abstracts of 14^th International Symposium on Healthy Aging. 2019, P61.

LYU Q., FAN R., Tsui Y.P., Chan Y.S., Shum D.K.Y. and Lai K.O., A knock-in strategy to study protein localization in human induced pluripotent stem cell (iPSC)-derived cortical neuron through genome editing, 13th Annual Canadian Neuroscience Meeting. 2019.

LYU Q., FAN R., ZHAO J., Tsui Y.P., Chan Y.S., Shum D.K.Y. and Lai K.O., A knock-in strategy to study protein localization in human induced pluripotent stem cell (iPSC)-derived cortical neuron through genome editing, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

Shen X., LIN L., LYU Q., ZHAO J., Chai A., Lai C.S., Chan Y.S. and Lai K.O., Impaired cognitive function and increased seizure susceptibility in mice depleted of the signalling protein TBC1D24, Abstracts of 14th International Symposium on Healthy Aging –Embrace the Golden Years : [HK. March 16-17, 2019]. 2019, P15.

Researcher : Lai KO

Project Title:	Investigating the regulatory role of protein arginine methylation in dendritic spine development
Investigator(s):	Lai KO
Department:	School of Biomedical Sciences
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	01/2016

Project Title:	Investigating the role of the kinesin motor KIF5B in dendritic mRNA trafficking in neurons
Investigator(s):	Lai KO, Huang J
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2017

Project Title:	Investigation of protein localization and transport dynamics in human neuron by genome editing
Investigator(s):	Lai KO, Shum DKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	05/2017
Completion Date:	04/2019

Project Title:	Cellular Mechanisms of Synaptic Functions and Plasticity in Health and Neurodegenerative Diseases
Investigator(s):	Lai KO
Department:	School of Biomedical Sciences
Source(s) of Funding:	Areas of Excellence Scheme
Start Date:	06/2017

Project Title:	Understanding the role of the protein arginine methyltrasnferase PRMT8 in determining the morphology of dendritic spines and localization of excitatory synapses in hippocampal neuron
Investigator(s):	Lai KO
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2018

Project Title:	Neuroscience 2018; The protein arginine methyltransferase PRMT8 regulates dendritic spine maturation and localization of excitatory synapses
Investigator(s):	Lai KO
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2018
Completion Date:	11/2018

Project Title:	Investigating the dual function of the epilepsy-related gene tbc1d24 in regulating excitatory and inhibitory synapses of neuron
Investigator(s):	Lai KO, Chan YS, Chang RCC, Lai SWC
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2019

Project Title:	A Stem Cell Approach to Dissect the Molecular Basis of Neurodegenerative Diseases
Investigator(s):	Lai KO
Department:	School of Biomedical Sciences
Source(s) of Funding:	Theme-based Research Scheme
Start Date:	01/2019

Project Title:	Elucidating the function of dynamic m6A methylation of synaptic mRNAs
Investigator(s):	Lai KO
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2019

Project Title:	Investigating the effect of Amyotrophic Lateral Sclerosis (ALS)-associated FUS mutations on connectivity of human induced pluripotent stem cell (iPSC)-derived cortical neuron
Investigator(s):	Lai KO, Cheung MCH
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2019

List of Research Outputs

FAN R., TAM K.K., CHAN H.L., Huang J. and Lai K.O., Elucidating the non-redundant role of different Kinesin 1 motor proteins in dendritic mRNA transport of neuron, 2019 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2019.

FAN R., CHAN H.L., Huang J. and Lai K.O., Elucidating the non-redundant role of different Kinesin 1 motor proteins in dendritic mRNA transport of neuron, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

FOK H.K., Lai K.O., Huang J. and Lai S.W.C., The Role of KIF5B, isoform of Kinesin 1 in Learning and Memory, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

FOK H.K., Lai K.O., Huang J. and Lai S.W.C., The role of KIF5B trafficking in learning and memory, 23rd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2018.

LIN L., LYU Q., Shen X., ZHAO J., Chai A. and Lai K.O., The epilepsy gene tbc1d24 encodes a novel synaptic protein that is required for the maintenance of excitatory synapses in hippocampal neuron, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

LIN L., LYU Q., Shen X., ZHAO J., Chai A. and Lai K.O., The epilepsy gene tbc1d24 encodes a novel synaptic protein that is required for the maintenance of excitatory synapses in neuron, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

LIN X., FENG D., DONG R., Lai K.O. and Gao B., Identification and characterization of the interactome of core Planar cell polarity (PCP) protein Vangl2, 2019 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2019.

LO H.Y.L., DONG R., LYU Q. and Lai K.O., The protein arginine methyltransferase PRMT8 regulates actin polymerization that is crucial for dendritic spine maturation and social behavior, 13th Annual Canadian Neuroscience Meeting. 2019.

LO H.Y.L., DONG R., LYU Q. and Lai K.O., The protein arginine methyltransferase PRMT8 regulates dendritic spine maturation and localization of excitatory synapses, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

LO H.Y.L., DONG R., LYU Q. and Lai K.O., The protein arginine methyltransferase PRMT8 regulates dendritic spine maturation and localization of excitatory synapses, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

LYU Q., FAN R., Tsui Y.P., Chan Y.S., Shum D.K.Y. and Lai K.O., ) The use of genome-editing to study the pathophysiological mechanism of brain disorders in human induced pluripotent stem cell (iPSC), Abstracts of 14^th International Symposium on Healthy Aging. 2019, P61.

LYU Q., FAN R., Tsui Y.P., Chan Y.S., Shum D.K.Y. and Lai K.O., A knock-in strategy to study protein localization in human induced pluripotent stem cell (iPSC)-derived cortical neuron through genome editing, 13th Annual Canadian Neuroscience Meeting. 2019.

LYU Q., FAN R., ZHAO J., Tsui Y.P., Chan Y.S., Shum D.K.Y. and Lai K.O., A knock-in strategy to study protein localization in human induced pluripotent stem cell (iPSC)-derived cortical neuron through genome editing, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

Lai K.O., Editorial Board member, Scientific Reports. 2019.

Lai K.O., Molecular basis of "synaptopathy" in neurodevelopmental disorders, Polytechnic University Biomedical Engineering Research Seminar. 2019.

Lai K.O., Molecular basis of "synaptopathy" in neurodevelopmental disorders, University of Hong Kong-University of Macau Joint Symposium. 2019.

Lai K.O., Review Editor, Frontiers in Molecular Neuroscience. 2019.

Lai K.O., Role of Kinesin in dendritic transport and regulation of synaptic function of neuron, 15th Meeting of the Asian-Pacific Society for Neurochemistry. 2018.

Shen X., Yeung H.T. and Lai K.O., Application of Human-Induced Pluripotent Stem Cells (hiPSCs) to Study Synaptopathy of Neurodevelopmental Disorders, Developmental Neurobiology. 2019, 79: 20-35.

Shen X., LIN L., LYU Q., ZHAO J., Chai A., Lai C.S., Chan Y.S. and Lai K.O., Impaired cognitive function and increased seizure susceptibility in mice depleted of the signalling protein TBC1D24, Abstracts of 14th International Symposium on Healthy Aging –Embrace the Golden Years : [HK. March 16-17, 2019]. 2019, P15.

Researcher : Lai SWC

Project Title:	Mechanism of fear associative learning in the frontal association cortex and its implications in schizophrenia
Investigator(s):	Lai SWC
Department:	School of Biomedical Sciences
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	10/2015

Project Title:	The role of sleep on fear learning and dendritic spine plasticity
Investigator(s):	Lai SWC, Cheung WH
Department:	School of Biomedical Sciences
Source(s) of Funding:	National Natural Science Foundation of China (NSFC) - General Program
Start Date:	01/2016

Project Title:	Mechanisms underlying the antidepressant effects of ketamine in an animal model of depression: the role of dendritic spines and interneurons
Investigator(s):	Lai SWC, Chang RCC, Lai KO
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2016
Completion Date:	04/2019

Project Title:	Reversible microcircuitry of fear learning and unlearning in the mouse auditory cortex
Investigator(s):	Lai SWC, Chan YS
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2017

Project Title:	Advanced optogenetics and functional calcium imaging platform for deep brain structures in awake, free-moving, and behaving animals in learning and memory
Investigator(s):	Lai SWC, Chan YS, Chang RCC, Chan SY, Cheung MCH, Lai KO, Lo ACY, Lee CW, Lim LW, Shum DKY, Wu W
Department:	School of Biomedical Sciences
Source(s) of Funding:	Small Equipment Grant
Start Date:	06/2017

Project Title:	The role of KIF5B in learning and memory
Investigator(s):	Lai SWC, Huang J, Lai KO
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017
Completion Date:	06/2019

Project Title:	Effects of environmental enrichment on synaptic plasticity in NMDAR hypofunction
Investigator(s):	Lai SWC
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2018

Project Title:	Annual meeting of Society for Neuroscience 2018; Effects of environmental enrichment in a mouse NMDA receptor hypofunction model
Investigator(s):	Lai SWC
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2018
Completion Date:	11/2018

Project Title:	The role of KIF5B on specific dendritic spine modifications and fear learning
Investigator(s):	Lai SWC
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2019

List of Research Outputs

FOK H.K., Lai K.O., Huang J. and Lai S.W.C., The Role of KIF5B, isoform of Kinesin 1 in Learning and Memory, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

FOK H.K., Lai K.O., Huang J. and Lai S.W.C., The role of KIF5B trafficking in learning and memory, 23rd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2018.

Lai S.W.C., Adler A. and Gan W.B., Fear extinction reverses dendritic spine formation induced by fear conditioning in the mouse auditory cortex, Proceedings of the National Academy of Sciences. 2018, 115: 9306-9311.

NG H.L.L., HUANG Y., Han L., Chang R.C.C., Chan Y.S. and Lai S.W.C., Ketamine and selective activation of parvalbumin interneurons inhibit stress-induced dendritic spine elimination., Translational psychiatry . 2018, 8.

Tan X., KONG C., Ren Y., Lai S.W.C., Tsia K.K.M. and Wong K.K.Y., Volumetric two-photon microscopy with a non-diffracting Airy beam, Optics Letters. 2019, 44: 391.

Researcher : Lai WL

List of Research Outputs

YEUNG S.F., Lai W.L. and Ching Y.P., PLK4 induce HCC migration via activation of Aurora A, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

Researcher : Lam CS

List of Research Outputs

Kang J.J., Guo B., Liang W.H., Lam C.S., Wu S.X., Huang X.F., Wong R.I.L.E.Y. .M.T.T., Fung M.L. and Liu Y.Y., Daily acute intermittent hypoxia induced dynamic changes in dendritic mitochondrial ultrastructure and cytochrome oxidase activity in the pre-Bötzinger complex of rats, Exp Neurol. 2019, 313: 124-134.

Researcher : Lam YM

List of Research Outputs

YANG X., Lam Y.M., Lui W.C. and Ng R.K., Epigenetic Dysregulation of CEBPE Expression in MLL-Rearranged Leukemia, 9th Japanese Society of Hematology (JSH) International Symposium 2018, July, 27-28, 2018, Kyoto, Japan. 2018.

Researcher : Lan Y

List of Research Outputs

Sy M.H., GUO Y., Lan Y., Ng H.W.H., Miao X. and Huen M.S.Y., Stabilization Of Imprinted Retrotransposon-derived Gene Peg10 By Deubiquitinase Usp9x, 2018 Gorden Research Conference: genomic instability. 2018.

Researcher : Lau CF

List of Research Outputs

Lin R., Duan Z., Sun H., Fung M.L., Chen H., Wang J., Lau C.F., Yang D., Liu Y., Ni Y., Wang Z., Cui J., Wu W., Yung W.H., Chan Y.S., Lo A.C.Y., Xia J., Shen J. and Huang J., Kinesin-1 Regulates Extrasynaptic Targeting of NMDARs and Neuronal Vulnerability Toward Excitotoxicity, iScience. 2019, 13: 82-97.

Researcher : Lau CYW

Project Title:	Structural role of the BRCA1-PALB2-BRCA2 complex in DNA repair
Investigator(s):	Lau CYW
Department:	School of Biomedical Sciences
Source(s) of Funding:	AXA Research Fund
Start Date:	08/2014

Researcher : Lau DSS

List of Research Outputs

Wang B., Bao S., ZHANG Z., ZHOU X., WANG J., Fan Y., Zhang Y., Li Y., Chen L.P., Jia Y., LI J., Li M., Zheng W., Mu N., Yang W., Yu Z., Lau D.S.S., Wong S.M., ZHANG Y., Kwan J.S.K., Mak H.K.F., Ambalavanan A., Zhou S., Cai W., Zheng J., Huang S., Rouleau G.A., Yang W., Rogaeva E., Ma X., St George-Hyslop P., Chu L.W. and Song Y., A rare variant in MLKL confers susceptibility to ApoE ɛ4-negative Alzheimer's disease in Hong Kong Chinese population, Neurobiol Aging. 2018, 68:160: e1-e7.

Researcher : Le W

List of Research Outputs

Yang Z., Yan T., Li S., Wei M., Qi H., Shen B., Chang R.C.C., Le W. and Piao F., Altered expression levels of microRNA-132 and Nurr1 in peripheral blood of Parkinson’s disease: a potential disease biomarker, ACS Chem. Neurosci.. 2019, 10: 2243-2249.

Researcher : Lee CW

Project Title:	Spatiotemporal regulation of actin monomers for promoting membrane protrusions in axonal growth, guidance and regeneration
Investigator(s):	Lee CW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	01/2017

Project Title:	Investigating the pathogenic mechanisms underlying ocular and generalized myasthenia gravis using Xenopus cell-based assay
Investigator(s):	Lee CW, Chan KH
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2017

Project Title:	Investigating the effects of ALS-linked mutations in Profilin on neuronal actin dynamics using an in vitro ALS model
Investigator(s):	Lee CW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2017
Completion Date:	05/2019

Project Title:	Site-directed trafficking and clustering of acetylcholine receptors in the formation of neuromuscular synapses
Investigator(s):	Lee CW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2018

Project Title:	The function of ECM-induced assembly of podosome-like structures in the formation and remodeling of AChR clusters at neuromuscular synapses
Investigator(s):	Lee CW, Zhou Z, Chan BP
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2019

Project Title:	Proteolytic activity of MT1-MMP in regulating neuromuscular synapse development and remodeling
Investigator(s):	Lee CW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2019

Project Title:	Cell Dynamics: Organelle-Cytoskeleton Interface; Podosome-directed vesicular trafficking and surface delivery of MT1-MMP at developing NMJs
Investigator(s):	Lee CW
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2019
Completion Date:	05/2019

List of Research Outputs

CHAN C.K., Wong Y.S., Jiang Z., Zhou Z. and Lee C.W., Podosome-directed MT1-MMP trafficking and surface insertion regulate AChR clustering and remodeling at developing NMJs, 2019 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2019.

Wood J., Tse C.L., Yang X., Brobst D., Liu Z., Zaw A.M., Chow B.K.C., Lee C.W., Chan C.B., PANG P.S.B., CHAN W.S. and Ye K., BDNF Mimetic alleviates body weight gain in obese mice by enhancing mitochondrial biogenesis in skeletal muscle, Metabolism. 2018, 87: 113-122.

Researcher : Lee K

List of Research Outputs

LAI S.L.M., Lee K. and Chang R.C.C., Visualization of neural pathways in Parkinson’s disease by transparent brain and neural tracing, The 14th International Symposium on Healthy Aging. 2019, 64.

Lee K., Lai H.M. and Chang R.C.C., Development of a tissue clearing technique for Alzheimer’s disease research, International Alzheimer’s Disease Conference 2019 . 2019, 44.

Lee K., Investigating an improved protocol for making the brain to be transparent for neuroscience research (MMedSc Dissertation), The University of Hong Kong. 2018.

Lee K., Lai H.M., SOERENSEN M.H., PANG C.C.C., Ho Y.S. and Chang R.C.C., Optimization of delipidation-based tissue clearing techniques for studying neuropathology in aging-associated neurodegenerative diseases, The 14th International Symposium on Healthy Aging. 2019, 62.

Wong P.Y., Lee K. and Chang R.C.C., Protocol for generating transparent adult zebrafish for investigating aging-associated neurodegenerative diseases, The 14th International Symposium on Healthy Aging. 2019, 62.

Researcher : Leung KKH

List of Research Outputs

TAM K.T., Leung K.K.H., Chen P., Kwong W.H., Pelling A., Pelling A., Lovell-Badge R.H. and Cheah K.S.E., From high to low: SOX2 dosage control of otic prosensory fate revealed by single cell transcriptome analyses, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

TAM K.T., Chen P., Leung K.K.H., Kwong M.W.H., Pelling A., Fritzsch B., Lovell-Badge R.H. and Cheah K.S.E., SOX2 dosage dependent control of otic cell identity revealed by single-cell transcriptome analyses, Japanese Society of Developmental Biologists Conference. 2019.

Wang C., Tan Z., Niu B., Tsang K.Y., Tai C.P., Chan W.C.W., Lo R.L.K., Leung K.K.H., Dung W.F., Itoh N., Zhang M.Q., Chan D. and Cheah K.S.E., Inhibiting the integrated stress response pathway prevents aberrant chondrocyte differentiation thereby alleviating chondrodysplasia, eLife. 2018, 7: e37673.

Researcher : Leung WYG

List of Research Outputs

NGAN W.L., Tsui M.G., So H.F., Leung W.Y.G., Chan D.W. and Yao K.M., Novel Nuclear Partnering Role of EPS8 With FOXM1 in Regulating Cell Proliferation, Frontiers in Oncology. 2019, 9.

Researcher : Li B

List of Research Outputs

Li B., Hong P., Zheng C.C., Dai W., Chen W.Y., Yang Q.S., Han L., Tsao G.S.W., Chan K.T., Lee N.P.Y., Law S.K., Xu L.Y., Li E.M., Chan K.W., Qin Y.R., Guan X., Lung M.L., He Q.Y., Xu W.W. and Cheung A., Identification of miR-29c and its Target FBXO31 as a Key Regulatory Mechanism in Esophageal Cancer Chemoresistance: Functional Validation and Clinical Significance., Theranostics 2019. 2019, 9(6):1599-1613.

Li B., Hong P., Zheng C.-.C., Dai W., Chen W.-.Y., Yang Q.-.S., HAN L., Tsao G.S.W., Chan K.T., Lee N.P.Y., Law S.Y.K., Xu L.Y., Li E.M., Chan K.W., Qin Y.R., Guan X., Lung M.L., He Q.-.Y., Xu W. and Cheung A., Identification of miR-29c and its Target FBXO31 as a Key Regulatory Mechanism in Esophageal Cancer Chemoresistance: Functional Validation and Clinical Significance, Theranostics. 2019, 9: 1599-1613.

Lin W., Yip Y.L., Jia L.J., Deng W., Zheng H., Dai W., Ko J.M.Y., Lo K.W., Chung G.T.Y., Yip K.Y., Lee S.D., Kwan J.S.H., Zhang J., Liu T.F., Chan Y.W., Kwong D.L.W., Lee V.H.F., Nicholls J.M., Busson P., Liu X.F., Chiang A.K.S., Hui K.F., Kwok H., Cheung S.T., Cheung Y.C., Chan C.K., Li B., Cheung A., Hau P.M., Zhou Y., Tsang C.M., Middeldorp J., Chen H., Lung M.L. and Tsao G.S.W., Establishment and characterization of new tumor xenografts and cancer cell lines from EBV-positive nasopharyngeal carcinoma, Nature Communications. 2018, 7; 9(1): 4663.

Xu W.W., Li B., Zhao J.F., Yang J.G., Li J.Q., Tsao G.S.W., He Q.Y. and Cheung A., IGF2 induces CD133 expression in esophageal cancer cells to promote cancer stemness, Cancer Letters. 2018, 425: 88-100.

ZHU Y., Li B., Xu W., Lam A.K.Y., Lee N.P.Y., Law S.Y.K. and Cheung A., Role of serglycin in promoting esophageal cancer invasion and metastasis, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

Researcher : Li CHS

List of Research Outputs

LOONG H.C., Wong T.L., Tong M., Sharma R., Zhou L., Ng K.Y., Li C.H.S. and Ma S.K.Y., Fucosyltransferase 1 (FUT1) sustains cancer stemness phenotype in hepatocellular carcinoma (HCC) under glucose restriction stress, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

Researcher : Li L

List of Research Outputs

KHONG M.L., Li L., Solesio M.E.T., Pavlov E. and Tanner J.A., Polyphosphate: a fundamental regulator of protein folding in human osteoblasts, The 43rd FEBS Congress, Prague, Czech Republic. 2018.

Li L., KHONG M.L., Lui E.L.H., Mebarek S., Magne D., Buchet R. and Tanner J.A., Long-chain polyphosphate in osteoblast matrix vesicles: Enrichment and inhibition of mineralization, Biochimica et Biophysica Acta (BBA) - General Subjects. 2019, 1863: 199-209.

Researcher : Li RA

Project Title:	Stem Cell and Regenerative Medicine
Investigator(s):	Li RA, Chan GCF, Tse HF
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	06/2013

Project Title:	Establishing a Molecular Encyclopedia for Stem Cell & Regenerative Medicine: Heart
Investigator(s):	Li RA, Tam PKH, Cheung YF
Department:	Dr. Li Dak-Sum Research Centre
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 2)
Start Date:	08/2016

Researcher : Li SK

Project Title:	A Study of the Roles of Hepatitis B Virus X Protein on the Transcriptional Regulation of Tumor Suppressor TAX1BP2 in Hepatocellular Carcinoma
Investigator(s):	Li SK, Ching YP
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	08/2016

List of Research Outputs

ZOU W., Li S.K. and Ching Y.P., Transcriptional regulation of TAX1BP2 in hepatocellular carcinoma, 23rd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2018.

ZOU W., Li S.K. and Ching Y.P., Transcriptional regulation of TAX1BP2 in hepatocellular carcinoma, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

ZOU W., Li S.K. and Ching Y.P., Transcriptional regulation of TAX1BP2, a putative tumor suppressor in hepatocellular carcinoma, 2019 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2019.

Researcher : Li Z

List of Research Outputs

LUI J., Li Z., SIT H.M., Zhang M. and Sham M.H., Dysregulation of Cel-Cell Interaction Genes in Sox10 Mutant Enteric Neural Crest Cells, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

LUI J., Li Z. and Sham M.H., The Role of ephrin-A1/EphA4 signaling in Enteric Neural Crest Cell Migration, 2019 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2019.

Researcher : Liang S

List of Research Outputs

LIANG S., An aptamer-based sensing platform for luteinising hormone pulsatility measurement (PhD Thesis), The University of Hong Kong. 2018.

Researcher : Lim B

List of Research Outputs

Fraser L.A., Kinghorn A.B., Dirkzwager R.M., Liang S., Cheung Y.W., Lim B., Shiu C.C., Tang S.L.M., Andrew D., Manitta J., Richards J.S. and Tanner J.A., A portable microfluidic Aptamer-Tethered Enzyme Capture (APTEC) biosensor for malaria diagnosis, Biosensors and Bioelectronics. 2018, 100(Supplement C): 591-596.

Researcher : Lim LW

Project Title:	Memory and cognitive enhancement by electrical stimulation in experimental animal models of dementia: In search of brain targets and mechanisms
Investigator(s):	Lim LW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Early Career Scheme (ECS)
Start Date:	10/2016

Project Title:	Hippocampal gene expression profiling after deep brain stimulation in aged animal model of cognitive impairment
Investigator(s):	Lim LW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	02/2017
Completion Date:	01/2019

Project Title:	3rd International Brain Stimulation Conference; Pacemaker in the aged brain: From molecular profiling to memory enhancement
Investigator(s):	Lim LW
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	02/2019
Completion Date:	02/2019

Project Title:	Investigation of cognitive enhancement and neuroprotective effects of Hericium erinaceus (Bull.:Fr.) Pers in a 5XFAD mouse model of Alzheimer’s disease.
Investigator(s):	Lim LW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Translational and Applied Research
Start Date:	06/2019

Project Title:	Investigation of neuroplasticity-dependent and independent mechanisms of non-invasive transcorneal electrical stimulation-induced antidepressants in a chronic unpredictable stress animal model of depression
Investigator(s):	Lim LW
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2019

List of Research Outputs

Bhaskar Y., Lim L.W. and Mitra R., Enriched environment facilitates anxiolytic efficacy driven by deep-brain stimulation of medial prefrontal cortex., In: Anthony J. Hannan, Frontiers in Behavioral Neuroscience. 2018.

Dennison O., Gao J., Lim L.W., Stagg C.J. and Aquili L., Catecholaminergic modulation of indices of cognitive flexibility: A pharmaco-tDCS study., Brain Stimulation. 2018.

Heng B.C.A., Jiang S., YI B., GONG T., Lim L.W. and Zhang C., Small molecules enhance neurogenic differentiation of dental-derived adult stem cells, Archives of Oral Biology. Elsevier, 2019, 102: 26-38.

Koh J., Lim W.L., Neoh J., Hescham S., Blokland A., Chan Y.S., Temel Y. and Lim L.W., Brain pacemaker and memory enhancement: Investigation of molecular mechanisms in the aged brain., International Alzheimer’s Disease Conference. Hong Kong.. 2018.

Koh J., Lim W.L., Zhang C.F., Heng B.C., Neoh J., Hescham S.A., Blokland A., Wu E.X., Chan Y.S., Temel Y. and Lim L.W., Pacemaker in the aged brain: From molecular profiling to memory enhancement, Abstracts of 14^th International Symposium on Healthy Aging –Embrace the Golden Years [HK. March 16-17, 2019]. 2019, P50.

Lim L.W., Pacemaker in the aged brain: From molecular profiling to memory enhancement., 3rd International Brain Stimulation Conference, Vancouver, Canada.. 2019.

SAW Y.L., MUHAMMAD SHARAFUDDIN BIN M.K., Tipoe G.L., Fung M.L. and Lim L.W., Investigation of stimulation parameters and neuroinflammation by electrical stimulation of the medial prefrontal cortex in an animal model of depression, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

SAW Y.L., Tipoe G.L., Fung M.L. and Lim L.W., Prelimbic cortical stimulation ameliorates the neuroinflammatoryinduced depressivelike and social behavioral deficits in rat models, 2019 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2019.

TAN Z.K.S., Chan Y.S. and Lim L.W., 2018 APSN Travel Fellowship Award (Oral), Asian-Pacific Society for Neurochemistry. 2018.

TAN Z.K.S., Chan Y.S. and Lim L.W., Deep brain stimulation of the medial prefrontal cortex disrupts consolidation of fear memories., 15th Meeting of the Asian-Pacific Society for Neurochemistry.. 2018.

TAN Z.K.S., POON C.H., Chan Y.S. and Lim L.W., Deep brain stimulation of the medial prefrontal cortex disrupts consolidation of fear memories, 23rd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2018.

TAN Z.K.S., POON C.H., Chan Y.S. and Lim L.W., Deep brain stimulation of the medial prefrontal cortex disrupts consolidation of fear memories, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

TAN Z.K.S., Chan Y.S. and Lim L.W., Dsruption consolidation of fear memory through deep brain stimulation of the medial prefrontal cortex, Soc. Neuroscience Abstract (USA) [San Diego. Nov. 3-7, 2018]. 2018, 272.05.

TAN Z.K.S., Sheng V., Chan Y.S. and Lim L.W., Eternal sunshine of the neuromodulated mind: Altering fear memories through neuromodulation, Experimental Neurology. 2019, 314: 9-19.

Veniaminova E., Kopeikina E., TAN Z.K.S., MUHAMMAD SHARAFUDDIN BIN M.K., Lesch K.P., Lim L.W., Strekalova T. and Ponomarev E., The impact of genetic lack ST3GAL5, the key enzyme in brain-specific ganglioside synthesis, on behaviour, metabolic regulation and neuroinflammation: a study in a new mouse model., 11th FENS, Forum of Neuroscience, Berlin 2018.

Wong K.H., Abd Majib M.A.B., Cheng P.G., Lim L.W., Richard R.L.A. and Mong Y.K., Gold Award on "Development of NEVGROTM for healthy gait and balance", Penang International Invention, Innovation and Design 2019, Universiti Teknologi MARA. 2019.

Wong K.H., Abd Majib M.A.B., Cheng P.G., Lim L.W., Richard R.L.A. and Mong Y.K., Most Outstanding (Academician) , Penang International Invention, Innovation & Design 2019, Universiti Teknologi MARA.. 2019.

Wong K.H., Abd Majib M.A.B., Cheng P.G., Lim L.W., Richard R.L.A. and Mong Y.K., Platinum Award on "Development of NEVGROTM for healthy gait and balance", Penang International Invention, Innovation and Design 2019, Universiti Teknologi MARA. 2019.

YU W.S., Guan L., Shrestha S., Or Y., Lufkin T., Chan Y.S., Lin V.C.L. and Lim L.W., TTC9A deficiency induces social anxiety and estrogen-mediated alterations on amygdala-hippocampal neuroplasticity-related gene expression of mice, 23rd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2018.

Researcher : Lim WL

List of Research Outputs

Koh J., Lim W.L., Neoh J., Hescham S., Blokland A., Chan Y.S., Temel Y. and Lim L.W., Brain pacemaker and memory enhancement: Investigation of molecular mechanisms in the aged brain., International Alzheimer’s Disease Conference. Hong Kong.. 2018.

Koh J., Lim W.L., Zhang C.F., Heng B.C., Neoh J., Hescham S.A., Blokland A., Wu E.X., Chan Y.S., Temel Y. and Lim L.W., Pacemaker in the aged brain: From molecular profiling to memory enhancement, Abstracts of 14^th International Symposium on Healthy Aging –Embrace the Golden Years [HK. March 16-17, 2019]. 2019, P50.

Researcher : Lin B

Project Title:	annual meeting of the association for research in vision and ophthalmology ; PTEN deletion enhances the survival of cone photoreceptors in retinal degeneration disorders
Investigator(s):	Lin B
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2016

Researcher : Lin Q

List of Research Outputs

ARYA S., LIN Q. and Huang J., mRNA therapeutics: a different vision, 23rd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2018.

ARYA S., Lin Q., Zhou N. and Huang J., mRNA therapeutics, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

Researcher : Lin W

List of Research Outputs

Lin W., Yip Y.L., Jia L.J., Deng W., Zheng H., Dai W., Ko J.M.Y., Lo K.W., Chung G.T.Y., Yip K.Y., Lee S.D., Kwan J.S.H., Zhang J., Liu T.F., Chan Y.W., Kwong D.L.W., Lee V.H.F., Nicholls J.M., Busson P., Liu X.F., Chiang A.K.S., Hui K.F., Kwok H., Cheung S.T., Cheung Y.C., Chan C.K., Li B., Cheung A., Hau P.M., Zhou Y., Tsang C.M., Middeldorp J., Chen H., Lung M.L. and Tsao G.S.W., Establishment and characterization of new tumor xenografts and cancer cell lines from EBV-positive nasopharyngeal carcinoma, Nature Communications. 2018, 7; 9(1): 4663.

Pang P.S., LIU T., Lin W., Tsang C.M., Yip Y.L., Zhou Y.L., Guan X., Chan R.C.K., Tsao G.S.W. and Deng W., Defining early events of Epstein–Barr virus (EBV) infection in immortalized nasopharyngeal epithelial cells using cell-free EBV infection, Journal of General Virology. 2019, 100: 999-1012.

Yip Y.L., Lin W., Deng W., Tsang C.M. and Tsao G.S.W., Establishment of Nasopharyngeal Carcinoma Cell Lines, Patient-Derived Xenografts, and Immortalized Nasopharyngeal Epithelial Cell Lines for Nasopharyngeal Carcinoma and Epstein–Barr Virus Infection Studies, Nasopharyngeal Carcinoma: From Etiology to Clinical Practice. Elsevier, 2019, 85-107.

Zhang J., Jia L.J., Liu T.E.N.G.F.E.I., Yip Y.L., Tang W.C., Lin W., Deng W., Lo K.W.O.K. .W.A.I., You C., Lung M.L., Lung H.L., Tsao G.S.W., Cheung A. and Tsang C.M., mTORC2-mediated PDHE1α nuclear translocation links EBV-LMP1 reprogrammed glucose metabolism to cancer metastasis in nasopharyngeal carcinoma., Oncogene. 2019, 38(24): 4669-4684.

Researcher : Liong EC

List of Research Outputs

Xiao J., Wang F., Liong E.C., So K.F. and Tipoe G.L., Lycium barbarum polysaccharides improve hepatic injury through NFkappa-B and NLRP3/6 pathways in a methionine choline deficient diet steatohepatitis mouse model, International Journal of Biological Macromolecules. 2018, 120: 1480-1489.

Researcher : Liu AJ

Project Title:	Investigating the therapeutic potential of human neural stem cells by suppressor of fused (SUFU) knockdown in a spinal cord injury model
Investigator(s):	Liu AJ, Chan YS, Chang RCC, Cheung MCH
Department:	Anaesthesiology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	06/2019

List of Research Outputs

YANG X., LIANG R., Liu C.X., Liu A.J., Cheung M.P.L., Liu X.L., Man O.Y., Guan X., Lung H.L. and Cheung M.C.H., SOX9 is a dose-dependent metastatic fate determinant in melanoma, Journal of Experimental & Clinical Cancer Research. 2019, 38.

Researcher : Liu B

Project Title:	Adult stem cell decline accelerates premature ageing in Zmpste24 deficient mice
Investigator(s):	Liu B, Zhou Z
Department:	School of Biomedical Sciences
Source(s) of Funding:	Small Project Funding
Start Date:	08/2008

Project Title:	Stem Cells 2009 Oxidative stress-mediated accelerated adult stem cell decline contributes to premature ageing in Zmpste24–/– mice
Investigator(s):	Liu B
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	11/2009

Project Title:	Quantitative mass spectrometry-based screening for SIRT1 deacetylating targets
Investigator(s):	Liu B, Zhou Z, Chu IK
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2012

Project Title:	Role of Autophagy in Cellular Senescence and Laminopathy-based Premature Ageing
Investigator(s):	Liu B
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	01/2013

Researcher : Liu P

List of Research Outputs

Lin S., Huang G., Cheng L., Li Z., Xiao Y., Deng Q., Jiang Y., Li B., Lin S., Wang S., Wu Q., Yao H., Cao S., Li Y., Liu P., Wei W., Pei D., Yao Y., Wen Z., Zhang X., Wu Y., Zhang Z., Cui S., Sun X., Qian X. and Li P., Establishment of peripheral blood mononuclear cell-derived humanized lung cancer mouse models for studying efficacy of PD-L1/PD-1 targeted immunotherapy, mAbs. 2018, 10: 1301-1311.

Yang J., Ryan D.J., Lan G., Zou X. and Liu P., In vitro establishment of expanded-potential stem cells from mouse pre-implantation embryos or embryonic stem cells, Nature Protocols. 2019.

Researcher : Liu R

List of Research Outputs

Researcher : Lovell-Badge RH

List of Research Outputs

Cheah K.S.E., Szeto Y.Y., Chu D.K.H., Au Y.K., Huang Y.H., Wynn S.L., Mak A.C.Y., Chan Y.S., Chan W.Y., Jauch R., Fritzsch B., Lovell-Badge R.H. and Sham M.H., Dual modes of cooperative repression by SOX9 and SOX10 and SOX9 transactivation of genes essential for inner ear fluid homeostasis maintain hearing., Gordon Research Conference on Neural Crest and Cranial Placodes. 2019.

TAM K.T., Leung K.K.H., Chen P., Kwong W.H., Pelling A., Pelling A., Lovell-Badge R.H. and Cheah K.S.E., From high to low: SOX2 dosage control of otic prosensory fate revealed by single cell transcriptome analyses, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

TAM K.T., Chen P., Leung K.K.H., Kwong M.W.H., Pelling A., Fritzsch B., Lovell-Badge R.H. and Cheah K.S.E., SOX2 dosage dependent control of otic cell identity revealed by single-cell transcriptome analyses, Japanese Society of Developmental Biologists Conference. 2019.

Researcher : Lui PY

List of Research Outputs

WONG L.Y.R., Lui P.Y., Siu K.L., Yeung M.L., Yuen K.S., Fung S.Y., Chan C.P., Woo P.C.Y., Yuen K.Y. and Jin D., Middle-East respiratory syndrome coronavirus ORF8b protein suppresses type I interferon production by interacting with HSP70, The American Society for Virology 37th Annual Meeting, University of Maryland, College Park, Maryland, USA, July 14-18, 2018.. 2018.

WONG L.Y.R., Ye Z., Lui P.Y., Siu K.L., Yeung M.L., Yuen K.S., Fung S.Y., Chan C.P., Cai Z., Woo P.C.Y., Yuen K.Y. and Jin D., Suppression of type I interferon production by Middle East respiratory syndrome coronavirus ORF8b accessory protein through interaction with HSP70 chaperone, Keystone Symposium on “Framing the Response to Emerging Virus Infections”, Pokfulam, Hong Kong. 2018.

Researcher : Lui WC

List of Research Outputs

YANG X., Lam Y.M., Lui W.C. and Ng R.K., Epigenetic Dysregulation of CEBPE Expression in MLL-Rearranged Leukemia, 9th Japanese Society of Hematology (JSH) International Symposium 2018, July, 27-28, 2018, Kyoto, Japan. 2018.

Researcher : Lui Kau WF

List of Research Outputs

CHE N., Ng K.Y., Tong M., Lui Kau W.F., Huen M.S.Y., Guan X. and Ma S.K.Y., Functional and Mechanistic Characterisation of PRMT6-regulated Autophagy in Hepatocellular Carcinoma, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

CHE N., Ng K.Y., Tong M., Lui Kau W.F., Guan X., Huen M.S.Y. and Ma S.K.Y., Functional and mechanistic characterization of PRMT6-regulated autophagy in hepatocellular carcinoma, 23rd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2018.

CHE N., Ng K.Y., Tong M., Lui Kau W.F., Guan X., Huen M.S.Y. and Ma S.K.Y., Protein arginine methylation by PRMT6 regulates autophagy in hostile microenvironment of hepatocellular carcinoma tumours, 2019 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2019.

CHE N., Ng K.Y., Tong M., Lui Kau W.F., Guan X., Huen M.S.Y. and Ma S.K.Y., Protein arginine methylation by PRMT6 regulates autophagy in hostile microenvironment of hepatocellular carcinoma tumours, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

Researcher : MA SKY

List of Research Outputs

CHAN L.H., Zhou L., Ng K.Y., Wong T.L., Lee T.K., Sharma R., LOONG H.C., Ching Y.P., Yuan Y.F., Xie D., Lo C.M., Man K., Artegiani B., Clevers H., Yan H.H.N., Leung S.Y., Richard S., Guan X., Huen M.S.Y. and Ma S.K.Y., Protein arginine methyltransferase PRMT6 regulates RAS/RAF binding and MEK/ERK-mediated cancer stemness activities in hepatocellular carcinoma through CRAF methylation, Cell Reports. 2018.

CHE N., Ng K.Y., Tong M., Lui Kau W.F., Huen M.S.Y., Guan X. and Ma S.K.Y., Functional and Mechanistic Characterisation of PRMT6-regulated Autophagy in Hepatocellular Carcinoma, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

CHE N., Ng K.Y., Tong M., Lui Kau W.F., Guan X., Huen M.S.Y. and Ma S.K.Y., Functional and mechanistic characterization of PRMT6-regulated autophagy in hepatocellular carcinoma, 23rd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2018.

CHE N., Ng K.Y., Tong M., Lui Kau W.F., Guan X., Huen M.S.Y. and Ma S.K.Y., Protein arginine methylation by PRMT6 regulates autophagy in hostile microenvironment of hepatocellular carcinoma tumours, 2019 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2019.

CHE N., Ng K.Y., Tong M., Lui Kau W.F., Guan X., Huen M.S.Y. and Ma S.K.Y., Protein arginine methylation by PRMT6 regulates autophagy in hostile microenvironment of hepatocellular carcinoma tumours, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

CHEUNG W.L., MA S.K.Y. and Chan D., Stem cell response to biomechanical changes in planarian regeneration, 23rd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2018.

Hu H., Gehart H., Artegiani B., LOpez-Iglesias C., Dekkers F., Basak O., van Es J., Chuva de Sousa Lopes S.M., Begthel H., Korving J., van den Born M., Zou C., Quirk C., Chiriboga L., Rice C.M., Ma S.K.Y., Rios A., Peters P.J., de Jong Y.P. and Clevers H., Long-Term Expansion of Functional Mouse and Human Hepatocytes as 3D Organoids, Cell. 2018, 175: 1591-1606.e19.

LOONG H.C., Wong T.L., Tong M., Sharma R., Zhou L., Ng K.Y., Li C.H.S. and Ma S.K.Y., Fucosyltransferase 1 (FUT1) sustains cancer stemness phenotype in hepatocellular carcinoma (HCC) under glucose restriction stress, Research Postgraduates Poster Presentation Session, School of Biomedical Sciences, The University of Hong Kong (13 Mar 2019). 2019.

LOONG H.C., Wong T.L., Sharma R., Zhou L., Ng K.Y., Li S. and Ma S.K.Y., Fucosyltransferase 1 (FUT1) sustains cancer stemness phenotype in hepatocellular carcinoma (HCC) under glucose restriction stress, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

LOONG H.C., Tong M., Wong T.L., Li S. and Ma S.K.Y., Fucosyltransferase 1 (FUT1) sustains cancer stemness phenotype in hepatocellular carcinoma under glucose restriction stress, 23rd Research Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2018.

Ma S.K.Y., Applications of organoid cultures in the study of gastric and liver cancer biology, Theme-based Research Scheme Symposium: Gastric Cancer Genomics and Beyond – Organoids, Genomics and Cell Biology, University of Hong Kong. 2018.

Ma S.K.Y., Arginine methylation by PRMT6 as a novel stemness and metabolic regulator in hepatocellular carcinoma, 2018 Beijing Liver Cancer International Conference, Beijing, China. 2018.

Ma S.K.Y., Arginine methylation by PRMT6 as a novel stemness and metabolic regulator in hepatocellular carcinoma, Stem Cell & Cancer Symposium 2018, University of Malaya, Kuala Lumpur, Malaysia. 2018.

Ma S.K.Y., Exploiting stemness as a cancer cell vulnerability using hepatocellular carcinoma as a model system, 4th Pan-Asian Biomedical Science Conference, Danang, Vietnam. 2018.

Ma S.K.Y., Exploiting stemness vulnerabilities of cancer, Faculty of Health Sciences of University of Macau and School of Biomedical Sciences of University of Hong Kong Joint Symposium, Macau. 2019.

Ma S.K.Y., Founding Member, Hong Kong Young Academy of Sciences, 2018.

Ma S.K.Y., Pre-clinical experimental models for improved precision medicine, Pre-Conference Workshop, 4th Pan-Asian Biomedical Science Conference, Danang, Vietnam. 2018.

Ma S.K.Y., Protein arginine methylation as a regulator of hepatic cancer stemness and glucose metabolism, School of Biomedical Sciences Research Day, Chinese University of Hong Kong. 2019.

SIN T.K., Li Y., Liu M., Ma S.K.Y. and Guan X., TROP-2 exhibits tumor suppressive functions in cervical cancer by dual inhibition of IGF-1R and ALK signaling, Gynecol Oncol. 2019, 152(1): 185-193.

Sin S.T., Li Y., Liu M., Yuan Y.F., Ma S.K.Y. and Guan X., Down-regulation of TROP-2 predicts poor prognosis of hepatocellular carcinoma patients, Hepatology Communications. 2018.

Yan H.H.N., Siu H.C., Law S.Y.K., Ho R.S.L., Yue S.K.S., Tsui W.Y., Chan D., Chan A.S., Ma S.K.Y., Lam K.O., Bartfeld S., Man H.Y., Lee C.H., Chan A.S.Y., Wong W.H.J., Cheng S.W.P., Chan K.W., Zhang J., Shi J., Fan X., Kwong D.L.W., Mak T.W., Yuen S.T., Clevers H. and Leung S.Y., A Comprehensive Human Gastric Cancer Organoid Biobank Captures Tumor Subtype Heterogeneity and Enables Therapeutic Screening, Cell Stem Cell. 2018.

Researcher : MAK HM

List of Research Outputs

MAK H.M., Role of Jmjd2b in Trophoblast Stemness Maintenance and Differentiation (MPhil Thesis), The University of Hong Kong. 2018.

Researcher : MUHAMMAD SHARAFUDDIN BIN MK

List of Research Outputs

SAW Y.L., MUHAMMAD SHARAFUDDIN BIN M.K., Tipoe G.L., Fung M.L. and Lim L.W., Investigation of stimulation parameters and neuroinflammation by electrical stimulation of the medial prefrontal cortex in an animal model of depression, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.

Veniaminova E., Kopeikina E., TAN Z.K.S., MUHAMMAD SHARAFUDDIN BIN M.K., Lesch K.P., Lim L.W., Strekalova T. and Ponomarev E., The impact of genetic lack ST3GAL5, the key enzyme in brain-specific ganglioside synthesis, on behaviour, metabolic regulation and neuroinflammation: a study in a new mouse model., 11th FENS, Forum of Neuroscience, Berlin 2018.

Researcher : Ma CW

List of Research Outputs

Chan Y.S., Ma C.W., Shi W. and Shum D.K.Y., Cannabinoid receptor suppresses long-term depression in the neonatal brain for consolidation of neuronal circuits for spatial cognition, Soc. Neuroscience Abstract (USA) 36.08 [San Diego. Nov. 3-7, 2018]. 2018, 36.08.

Chan Y.S., LAM T.F., JIANG Y., Wu L.K., Ma C.W. and Wang J.J., Orexin delays activity-dependent maturation of the vestibular system in rats, Abstracts of 11^th FENS Forum of Neuroscience. 2018, 691.

Chan Y.S., KWAN P.Y., Tam K.W., Ma C.W., Wu L.K. and Shum D.K.Y., Perineuronal net and semaphorin regulate developmental plasticity of the central vestibular circuitry for sensori-motor function, Abstracts of 15^th Conference of Asia-Pacific Society for Neurochemistry. 2018, 82.

Chan Y.S., Wu L.K., JIANG Q., Ma C.W. and Shum D.K.Y., Postnatal refinement of circuit plasticity for spatial navigation, Proc. 9^th Congress of Federation of Asian-Oceanian Physiological Societies [Kobe. March 28-31, 2019]. 2019, 61.

Ma C.W., Nursing students’ perceptions of biomedical education with augmented reality, Integrative Biomedical Sciences. 2019, 5: 70-73.

Ma C.W., Kwan T.P., Wu K.L., Shum D.K.Y. and Chan Y.S., Regulatory role of perineuronal nets and semaphorin 3A in the postnatal maturation of the central vestibular circuitry for graviceptive reflex, Brain Structure and Function. 2019, 224: 613-626.

Ma C.W., Kwan P.Y., Wu L.K., Shum D.K.Y. and Chan Y.S., Regulatory roles of perineuronal nets and semaphorin 3A in the postnatal maturation of the central vestibular circuitry for graviceptive reflex, Brain Structure and Function. 2019, 224: 613-626.

Shum D.K.Y., KWAN P.Y., Ho S.N.S., Hau W.F., Tam K.W., Wu L.K., Ma C.W. and Chan Y.S., Dynamics of perineuronal net-associated plastic factors after sensory loss, Abstracts of 15^th Meeting of Asian-Pacific Society for Neurochemistry [Macau. Aug. 27-29, 2018]. 2018, 80.

Shum D.K.Y., KWAN P.Y., HAU W.F., Tam K.W., Wu L.K., Ma C.W. and Chan Y.S., Dynamics of perineuronal net-associated plastic factors after sensory loss, Abstracts of 15^th Meeting of Asian-Pacific Society for Neurochemistry, 80. [Macau. Aug. 27-29, 2018]. 2018, 80.

Wu L.K., Ho S.N., Hau W.F., Ma C.W., Shum D.K.Y. and Chan Y.S., Dynamics of perineuronal net-associated plastic factors after sensory loss, 11th FENS Forum of Neuroscience. 2018.

Wu L.K., Ho S.S.N., HAU W.F., Ma C.W., Shum D.K.Y. and Chan Y.S., Dynamics of perineuronal net-associated plastic factors after sensory loss, Abstracts of 11^th FENS Forum of Neuroscience. 2018, 1106.

Researcher : Ma SKY

Project Title:	Outstanding Young Researcher Award 2012-13
Investigator(s):	Ma SKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	01/2014

Project Title:	A multidisciplinary study on hepatic cancer stem cells
Investigator(s):	Ma SKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Croucher Innovation Awards
Start Date:	04/2014

Project Title:	A Multidisciplinary Study on CD133 Liver Cancer Stem Cells: Molecular Mechanisms, Clinical Relevance and Therapeutic Implications
Investigator(s):	Ma SKY, Guan X, Lo CM, Man K
Department:	School of Biomedical Sciences
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2015

Project Title:	Role of PRMT6 in regulating cancer and stemness properties in hepatocellular carcinoma
Investigator(s):	Ma SKY, Leung SY, Yan HHN
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2016

Project Title:	Role of MAPK11 in liver cancer stem cells
Investigator(s):	Ma SKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2017
Completion Date:	09/2018

Project Title:	A Multidisciplinary Study on CD133 Liver Cancer Stem Cells: Molecular Mechanisms, Clinical Relevance and Therapeutic Implications (CRF)
Investigator(s):	Ma SKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Funding for Strategic Interdisciplinary Research Scheme
Start Date:	06/2017

Project Title:	Role of protein arginine methyltransferase 6 (PRMT6) in metabolic reprogramming in hepatocellular carcinoma
Investigator(s):	Ma SKY, Wong CCL
Department:	School of Biomedical Sciences
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2018

Project Title:	PRMT6 binds to and methylates BAG5, BAG6, AMBRA1 and SQSTM1 to regulate autophagy in liver cancer
Investigator(s):	Ma SKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	04/2018

Project Title:	Establishment, characterization and applications of normal liver and hepatocellular carcinoma organoid cultures
Investigator(s):	Ma SKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Translational and Applied Research
Start Date:	05/2018

Project Title:	A study of the role and therapeutic potential of targeting protein tyrosine kinase 7 (PTK7) in liver cancer
Investigator(s):	Ma SKY, Man K
Department:	School of Biomedical Sciences
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	07/2018

Project Title:	AACR Annual Meeting; Down-regulation of PRMT6 drives Warburg effect through ERK induced relocalization of PKM2 to promote tumorigenicity and sorafenib resistance in hepatocellular carcinoma
Investigator(s):	Ma SKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2019

Project Title:	Exploiting stemness as a cancer cell vulnerability using hepatocellular carcinoma (HCC) as a model system
Investigator(s):	Ma SKY, Guan X, Ho JWK, Lo CM, Man K, Wong SL
Department:	School of Biomedical Sciences
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	04/2019

Project Title:	Molecular and mechanistic characterization of FUT1 mediated cancer stemness in a glucose restricted liver tumor microenvironment
Investigator(s):	Ma SKY, Sharma R
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Basic Research
Start Date:	06/2019

Project Title:	A pre-clinical study to evaluate the therapeutic efficacy of FSTL1 neutralizing antibody in combination with sorafenib for the treatment of HCC
Investigator(s):	Ma SKY
Department:	School of Biomedical Sciences
Source(s) of Funding:	Seed Fund for Translational and Applied Research
Start Date:	06/2019