DEPT OF MEDICINE



Researcher : Au KW

List of Research Outputs

Cheung Y.Y., Lee C.H.P., Tang S.M., Xu A., Au K.W., Fong H.Y., Ng K.K., KWOK H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Hai S.H.J.J., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Genetic regulation of Pigment Epithelium-Derived Factor (PEDF): an exome-chip association analysis in Chinese subjects with type 2 diabetes, Diabetes. 2019, 68: 198-206.
Wong Y.K., Cheung Y.Y., Tang S.M., Au K.W., Hai S.H.J.J., Lee C.H.P., Lau G.K.K., Cheung B.M.Y., Sham P.C., Xu A., Lam K.S.L. and Tse H.F., Age-Biomarkers-Clinical Risk Factors for Prediction of Cardiovascular Events in Patients With Coronary Artery Disease., Arterioscler Thromb Vasc Biol. American Heart Association, Inc., 2018, 38: 2519-2527.


Researcher : BAI Y

List of Research Outputs

BAI Y. and Chim J.C.S., Ficolled bone marrow is superior to bone marrow buffy coat for detection of minimal residual disease in multiple myeloma, Hematology. 2019, 24: 533-537.
YAO Q., BAI Y., Orfao A. and Chim J.C.S., Standardized Minimal Residual Disease Detection by Next-Generation Sequencing in Multiple Myeloma, Frontiers in Oncology. 2019, 9.


Researcher : Bu L

Project Title:Investigation of the relationship between ISL1+ and WT1+ heart progenitor cells in humans
Investigator(s):Bu L, Li RA
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:06/2012




Researcher : But YKD

List of Research Outputs

But Y.K.D., What is the role for cabozantinib as a new option in second-line aHCC?, 1st Ipsen Asia-Pacific Advisory Board in Hepatocellular Carcinoma, Seoul, South Korea. 2018.
Hui Y.T., Wong G.L.H., Fung J.Y.Y., Chan H.L.Y., Leung N.W.Y., Liu S.D., Liu K., Ma Y.K., But Y.K.D., Mak W.Y., Chan J.M.C., Lai K.B., Loo C.K., Ng A.C.Y., Lai M.S., Chan C.W., Lau J.Y.L., Fan T.T.T., Hui A.J., Lam B.C.Y., Cheung W.I., Tsang O.T.Y., Lam K., Lai L.S.W., Luk W.F., Lao M.K.K., Lao W.C., Lam J.T.W., Tsang S.W.C., Kung K.N., Chow W.H., Tong R.K.N., Lui K.L., Shan E.H.S., Yuen R.M.F. and Wong V.W.S., Territory-wide population-based study of chronic hepatitis C infection and implications for hepatitis elimination in Hong Kong, Liver International. 2018, 38(11): 1911-1919.


Researcher : CHAN LY

List of Research Outputs

Chan L.Y. and Chung H.Y., Sulfasalazine-Induced Connective Tissue Disease, JCR: Journal of Clinical Rheumatology. 2019, 1.
LI B., Leung J.C.K., Chan L.Y., Yiu W.H., Lai K.N. and Tang S.C.W., Mesenchymal Stem Cells Derived from Induced Pluripotent Stem Cells and Bone Marrow Are Equally Effective in Ameliorating Lipotoxicity-Induced Kidney Injury (Conference Abstract)., J Am Soc Nephrol. 2018, 29: 284.
Yiu W.H., Wong D.W., LOK W.Y., Liu W.H., LI Y., CHAN L.Y., Leung J.C.K., Lan H.Y. and Tang S.C.W., The Long Noncoding RNA Meg3 Mediates TLR4–Induced Renal Inflammation in Experimental Obstructive Nephropathy (Conference Abstracts) , J Am Soc Nephrol . 2018, 29: 953.


Researcher : CHEN L

List of Research Outputs

Cheung K.S.M., Chen L., Seto W.K.W. and Leung W.K., Best Abstract Award in Clinical Medicine (oral presentation), 24th Medical Research Conference, Hong Kong, The University of Hong Kong . 2019.
Cheung K.S.M., Chen L., Seto W.K.W. and Leung W.K., Epidemiology, characteristics and survival of post-colonoscopy colorectal cancer in Hong Kong: a population-based study, Medical Research Conference. 2019.
Cheung K.S.M., Chen L., Seto W.K.W. and Leung W.K., Epidemiology, characteristics and survival of post‐colonoscopy colorectal cancer in Asia: a population‐based study, Journal of Gastroenterology and Hepatology. 2019.
Cheung K.S.M., Chan E.W., Wong A.Y., Chen L., Seto W.K.W., Wong I.C.K. and Leung W.K., Metformin Use and Gastric Cancer Risk in Diabetic Patients After Helicobacter pylori Eradication, JNCI: Journal of the National Cancer Institute. 2018.
Cheung K.S.M., Chan E.W.Y., Wong A.S.Y., Chen L., Seto W.K.W., Wong I.C.K. and Leung W.K., Statin use and gastric cancer risk in Helicobacter pylori-eradicated patients: a territory-wide study with propensity score matching, Medical Research Conference, Hong Kong. 2019.
Cheung K.S.M., Chen L., Chan E.W., Seto W.K.W., Wong I.C.K. and Leung W.K., Statins reduce the progression of non-advanced adenomas to colorectal cancer: a postcolonoscopy study in 187 897 patients, Gut. 2019, gutjnl-2018-317714.
Cheung K.S.M., Chan E.W.Y., Chen L., Seto W.K.W., Wong I.C.K. and Leung W.K., Use of non-aspirin non-steroidal anti-inflammatory drugs and risk of post-colonoscopy colorectal cancer: a territory-wide study with propensity score analysis, Digestive Disease Week . 2019.
GUO C., Cheung K.S.M., Zhang F., Chan E.W.Y., Chen L., Wong I.C.K. and Leung W.K., Incidences, temporal trends and risks of hospitalisation for gastrointestinal bleeding in new or chronic low-dose aspirin users after treatment for Helicobacter pylori : a territory-wide cohort study , Gut. 2019, gutjnl-2019-318352.
GUO C., Chen L., Chan E.W.Y., Cheung K.S.M., Isshiki T., Wong I.C.K. and Leung W.K., Systematic review with meta- analysis: the risk of gastrointestinal bleeding in patients taking third-generation P2Y12 inhibitors compared with clopidogrel, Alimentary Pharmacology & Therapeutics. 2019.
JIANG D., XIONG G., FENG H., ZHANG Z., Chen P., Yan B., CHEN L., Kesavamoorthy G., MA C.Y., Li C., HAN S., Zhang Y., Liao C., Lee T.L., Tse H.F., Fu Q.L., Chiu K. and Lian Q., Donation of mitochondria by iPSC-derived mesenchymal stem cells protects retinal ganglion cells against mitochondrial complex I defect-induced degeneration, Theranostics. Australia, Ivyspring International Publisher, 2019, 2019, Vol. 9, Issue 8: 2395-2410.
Leung W.K., Chen L., Seto W.K.W. and Cheung K.S.M., Characteristics and risk factors of post-colonoscopy interval cancers: a population-based study from Asia, Digestive Disease Week. 2019.


Researcher : CHEN R

List of Research Outputs

CHEN R., Ip M.S.M. and Mak J.C.W., Effect of cigarette smoke on airway inflammation and mucus hypersecretion in submerged and well-differentiated airway epithelial cells, 24th Medical Research Conference, Department of Medicine, HKU. Hong Kong Medical Journal. 2019, 25 (Suppl 1): 11.
CHEN R., Yeung S.C., Ip M.S.M. and Mak J.C.W., The Role of ORMDL3 in Cigarette Smoke-induced Airway Injury, American Thoracic Society (ATS) and International Society of Respiratory Diseases (ISRD). 2019, 199: A3759.
CHEN R., Yeung S.C., Ip M.S.M. and Mak J.C.W., The role of ORMDL3 in cigarette smoke-induced airway injury, American Thoracic Society (ATS) International Conference 2019. 199: A3759.


Researcher : CHEN Y

List of Research Outputs

CHEN Y., Au T.W.K., Chan D., Sit K.Y., Zhen Z., Ho K.L., Wong D., Ho L.M., Yap Y.H.D., Lam Y.M., Lau C.P., Tse H.F., Chan D.T.M. and Yiu K.H., Clinical Benefit of Valvular Surgery in Patients with Chronic Kidney Disease, International Heart Journal. 2018, 59: 759-765.
CHEN Y., Liu Y., Seto W.K.W., Wu M., YU Y., Lam Y.M., Au W.K., Chan D., Sit K.Y., Ho L.M., Tse H.F. and Yiu K.H., Prognostic Value of Hepatorenal Function By Modified Model for End‐stage Liver Disease (MELD) Score in Patients Undergoing Tricuspid Annuloplasty, Journal of the American Heart Association. 2018, 7: e009020.
Chan Y.H., Ngai M.C., Chen Y., Wu M., YU Y., ZHEN Z., Lai K.W.H., Cheung T.T., Ho L.M., Chung H.Y., Lau W.C.S., Tse H.F. and Yiu K.H., Cumulative Rheumatic Inflammation Modulates the Bone–Vascular Axis and Risk of Coronary Calcification, Journal of the American Heart Association. 2019, 8.
Chan Y.H., Ngai M.C., Chen Y., Wu M., YU Y., ZHEN Z., Lai K.W.H., Cheung T.T., Ho L.M., Chung H.Y., Lau W.C.S., Lau C.P., Tse H.F. and Yiu K.H., Osteogenic circulating endothelial progenitor cells are linked to electrocardiographic conduction abnormalities in rheumatic patients, Annals of Noninvasive Electrocardiology. 2019, e12651.
Chen Y., Au T.W.K., Chan D., Sit K.Y., Zhen Z., Ho K.L., Wong D., Ho L.M., Yap Y.H.D., Lam Y.M., Lau C.P., Tse H.F., Chan D.T.M. and Yiu K.H., Clinical Benefit of Valvular Surgery in Patients with Chronic Kidney Disease. , International heart journal. 2018, 59(4): 759-765.
Chen Y., Liu Y., Seto W.K.W., Wu M., YU Y., Lam Y.M., Au T.W.K., Sit K.Y., Ho L.M., Tse H.F. and Yiu K.H., Prognostic Value of Hepatorenal Function By Modified Model for End-stage Liver Disease (MELD) Score in Patients Undergoing Tricuspid Annuloplasty, Journal of the American Heart Association. 2018, 7(14): 1-11.
Chen Y., Liu Y., Wu M., Lam Y.M., Ho L.M., Lau C.P., Au T.W.K., Tse H.F. and Yiu K.H., Prognostic value of tricuspid valve geometry and leaflet coaptation status in patients undergoing tricuspid annuloplasty: a three-dimensional echocardiography study, PCR Tokyo Valves 2019.
Wu M., Chen Y., Au T.W.K., Chan D., Sit K.Y., Ho K.L., Ho L.M., Lam Y.M., Lau C.P., Chan D.T.M., Tse H.F. and Yiu K.H., Predictive value of acute kidney injury for major adverse cardiovascular events following tricuspid annuloplasty: A comparison of three consensus criteria, Journal of Cardiology. 2018, 72: 247-254.


Researcher : CHOW JX

List of Research Outputs

CHOW J.X., Lam K.Y.I., Wong Y.Y.S., Lau W.C.S. and Chan V.S.F., Dysregulation of AIM2 inflammasome response in patients with Systemic Lupus Erythematosus, 13th World Immune Regulation Meeting. 2019.


Researcher : Cai Z

List of Research Outputs

Ng K.M., Lau V.Y.M., Vidhu D., Cai Z., Lee Y.K., Lai K.W.H., Tse H.F. and Siu D.C.W., Empagliflozin Ammeliorates High Glucose Induced-Cardiac Dysfuntion in Human iPSC-Derived Cardiomyocytes, Scientific Reports. 2018, 8.


Researcher : Chan CYC

List of Research Outputs

Chan D.T.M., Ho S., Tai C.P., Chan C.Y.C., Chau K.M. and Yung S.S.Y., Anti-dsDNA antibodies bind to Ku70 in proximal renal tubular epithelial cells and increase matrix protein synthesis and MCP-1 secretion, ISN World Congress of Nephrology 2019.
Chan D.T.M., Ho S.S.K., Tai C.P., Chan C.Y.C., Cheng W.M., Chau K.M. and Yung S.S.Y., Anti-dsDNA antibodies bind to Ku70 in proximal renal tubular epithelial cells and increased matrix protein and cytokine secretion, American Society of Nephrology Kidney Week 2018.
YU J., Yung S.S.Y., Chan C.Y.C., Chau K.M. and Chan D.T.M., Gut-derived lipopolysaccharide contributes to pathogenesis of lupus nephritis, ISN World Congress of Nephrology 2019.


Researcher : Chan CYJ

Project Title:Registry of Severe Cutaneous Adverse Drug Reactions and Epidemiological study in Hong Kong (RESCUE-HK)
Investigator(s):Chan CYJ, Cheung BMY, Wong ICK, Cheung CL, Yeung CK, Shih KC, Chan CLR
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:08/2016




Researcher : Chan DTM

Project Title:Gut Microbiota Products in the Pathogenesis of Lupus Nephritis
Investigator(s):Chan DTM, Yung SSY, Yap YHD
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:01/2014


Project Title:The role of Ku70 and Ku80 in the pathogenesis of lupus nephritis
Investigator(s):Chan DTM, Yung SSY
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2015
Completion Date:12/2018


Project Title:The Role of Major Vault Protein in Tubulo-interstitial Injury during Lupus Nephritis
Investigator(s):Chan DTM, Yung SSY
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:06/2015


Project Title:ASN Kidney Week 2015 Annual Meeting; Serum Acetate and Lipopolysaccharide Levels Correlate with Disease Activity in Patients with Lupus Nephritis
Investigator(s):Chan DTM
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:11/2015


Project Title:The roles of lipopolysaccharide, lipopolysaccharide binding protein and CD14 in the pathogenesis of lupus nephritis
Investigator(s):Chan DTM, Yung SSY
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2016


Project Title:Acetate in the Pathogenesis of Lupus Nephritis
Investigator(s):Chan DTM, Yung SSY
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2017


Project Title:Role of Major Vault Protein in Fibrotic Processes in Human Mesangial Cells and Proximal Renal Tubular Epithelial Cells
Investigator(s):Chan DTM, Yung SSY
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:06/2017
Completion Date:05/2019


Project Title:Major Vault Protein in Tubulo-interstitial Damage of Chronic Kidney Disease
Investigator(s):Chan DTM, Yung SSY
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2018


Project Title:The Role of Lipopolysaccharide on CD44-mediated Kidney Inflammation and Fibrosis in Lupus Nephritis
Investigator(s):Chan DTM, Yung SSY
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:06/2018


Project Title:American Society of Nephrology Kidney Week 2018; Anti-dsDNA Antibodies Bind to Ku70 in Proximal Renal Tubular Epithelial Cells and Increased Matrix Protein and Cytokine Secretion
Investigator(s):Chan DTM
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2018
Completion Date:10/2018


Project Title:Role of interstitial renal fibroblasts in chronic kidney disease
Investigator(s):Chan DTM, Yung SSY
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:06/2019


List of Research Outputs

. 倪.兆.慧., Ronco C., . 牟.姗., Davies S. and Chan D.T.M., 腎脏疾病的转化医学研究和临床实践, 转化医学出版工程,“十三五”. 国家重点图书出版规划项目, 上海科技专著出版资金资助项目, 2019.
CHEN Y., Au T.W.K., Chan D., Sit K.Y., Zhen Z., Ho K.L., Wong D., Ho L.M., Yap Y.H.D., Lam Y.M., Lau C.P., Tse H.F., Chan D.T.M. and Yiu K.H., Clinical Benefit of Valvular Surgery in Patients with Chronic Kidney Disease, International Heart Journal. 2018, 59: 759-765.
Chan D.T.M., Appel G.B., Furie R., Wofsy D., Takeuchi T., Malvar A., Doria A., Romero-Diaz J., Elege A., Jayne D., Dooley M.A. and Maldonado M.A., A Phase III randomized double-blind placebo-controlled study to evaluate the efficacy and safety of abatacept or placebo on standard of care in patients with active Class III or IV lupus nephritis, [Plenary Session oral presentation] at the 39th Korean College of Rheumatology Annual Scientific Meeting, 16-18 May. Seoul, South Korea, 2019.
Chan D.T.M., Ho S., Tai C.P., Chan C.Y.C., Chau K.M. and Yung S.S.Y., Anti-dsDNA antibodies bind to Ku70 in proximal renal tubular epithelial cells and increase matrix protein synthesis and MCP-1 secretion, ISN World Congress of Nephrology 2019.
Chan D.T.M., Ho S.S.K., Tai C.P., Chan C.Y.C., Cheng W.M., Chau K.M. and Yung S.S.Y., Anti-dsDNA antibodies bind to Ku70 in proximal renal tubular epithelial cells and increased matrix protein and cytokine secretion, American Society of Nephrology Kidney Week 2018.
Chan D.T.M., Challenges in the management of kidney transplant patients, at the 8th Oriental Congress of Nephrology in conjunction with ISN-GO CME Course, 18-20 October 2018, Shanghai, China. 2018.
Chan D.T.M., Chapter 80 "Far East" , in "Brenner & Rector's The Kidney (11th Edition)" Skorecki K, Chertow GM, Marsden PA, Taal MW, and Yu ASL, Editors. USA, Elsevier, Cambridge, MA -2139, 2019.
Chan D.T.M., Clinico-Pathological Basis of Lupus Nephritis Management, at 2018 Shenzhen & Hong Kong Renal Pathology and Clinical Management Academy, University of Hong Kong Shenzhen Hospital, 11 November, Shenzhen, China., 2018.
Chan D.T.M., Commentary on the TRANSFORM study of everolimus and infection rate in kidney transplant recipients, at 5th Kidney Transplant Asian Summit, Transplantation Society of Taiwan, 13-14 October, Taipei, Taiwan., 2018.
Chan D.T.M., Corticosteroids in the treatment of IgA nephropathy: any light beyond the clouds of confusion?, Postgraduate Medical Journal. 2018, 94(113): 371-373.
Chan D.T.M., How I manage my difficult-to-treat lupus nephritis patients, at the Annual Convention of the Philippine Society of Nephrology, 24-27 April, Manila, Philippines., 2019.
Chan D.T.M., Lupus Nephritis Clinical Management, at “内地-香港前沿学科论坛:肾脏病学从基础研究到临床诊治”organized by Chinese Society of Nephrology and supported by 国家自然基金委港澳台事务办, 6-8 May, Hangzhou, China, 2019.
Chan D.T.M., Lupus Nephritis – Recent Advances, at the Grand Bay Forum on Nephrology 2018, Guangdong Society of Nephrology, Chinese Medical Association, 7-8 December, Hilton Wanda Plaza, Guangzhou, China., 2018.
Chan D.T.M., Lupus nephritis management without long-term steroids?, at the Annual Philippine Rheumatology Meeting, Philippine Rheumatology Association, 6-9 March, Davao, Philippines., 2019.
Chan D.T.M., Management of lupus nephritis – mycophenolate and beyond, in Lupus and Glomerulonephritis Update, Postgraduate Institute of Medical Education & Research, 22-24 February, Chandigarh, India., 2019.
Chan D.T.M., Managing lupus flares effectively, at the Annual Philippine Rheumatology Meeting, Philippine Rheumatology Association, 6-9 March, Davao, Philippines., 2019.
Chan D.T.M., Significance and Management of Relapses in Lupus Nephritis, at 8th Oriental Congress of Nephrology, Shanghai Society of Nephrology, Chinese Society of Nephrology, in conjunction with International Society of Nephrology Global Outreach CME, 18-20 October, Shanghai, China., 2018.
Chan D.T.M., Significance and prevention of disease flare in lupus nephritis, at Autoimmune Disease Expert Academy Meeting, 21 July 2018, Tokyo, Japan. 2018.
Chan D.T.M., The failing kidney allograft, at the Annual Convention of the Philippine Society of Nephrology, 24-27 April, Manila, Philippines., 2019.
Chan D.T.M., Ultrafiltration failure in CAPD, at the 13th Annual Meeting of the Indonesian Society of Nephrology, 21-23 September 2017, Malang, Indonesia. 2018.
Chan D.T.M., Update of immunosuppressive treatment for lupus nephritis, at the 13th Annual Meeting of the Indonesian Society of Nephrology, 21-23 September2017, Malang, Indonesia. 2018.
Chan D.T.M., What is new in the treatment of lupus nephritis, in the 2019 World Congress of Nephrology organized by the International Society of Nephrology in conjunction with 16th Asian Pacific Congress of Nephrology, 12-15 April 2019, Melbourne, Australia. 2019.
Chen Y., Au T.W.K., Chan D., Sit K.Y., Zhen Z., Ho K.L., Wong D., Ho L.M., Yap Y.H.D., Lam Y.M., Lau C.P., Tse H.F., Chan D.T.M. and Yiu K.H., Clinical Benefit of Valvular Surgery in Patients with Chronic Kidney Disease. , International heart journal. 2018, 59(4): 759-765.
Floege J., Barbour S.J., Cattran D.C., Hogan J.J., Nachman P.H., Tang S.C.W., Wetzels J.F.M., Cheung M., Wheeler D.C., Winkelmayer W.C., Rovin B.H., Adler S.G., Alpers C.E., Ayoub I., Bagga A., Barratt J., Caster D.J., Chan D.T.M., Chang A., Choo J.C.J., Cook H.T., Coppo R., Fervenza F.C., Fogo A.B., Fox J.G., Gibson K.L., Glassock R.J., Harris D., Hodson E.M., Hoxha E., Iseki K., Jennette J.C., Jha V., Johnson D.W., Kaname S., Katafuchi R., Kitching A.R., Lafayette R.A., Li P.K.T., Liew A., Lv J., Malvar A., Maruyama S., Mejía-Vilet J.M., Moeller M.J., Mok C.C., Nester C.M., Noiri E., O'Shaughnessy M.M., Özen S., Parikh S.M., Park H.C., Peh C.A., Pendergraft W.F., Pickering M.C., Pillebout E., Radhakrishnan J., Rathi M., Roccatello D., Ronco P., Smoyer W.E., Tesař V., Thurman J.M., Trimarchi H., Vivarelli M., Walters G.D., Wang A.Y.M. and Wenderfer S.E., Management and treatment of glomerular diseases (part 1): conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference, Kidney International. 2019, 95: 268-280.
Heerspink H.J.L., Greene T., Tighiouart H., Gansevoort R.T., Coresh J., Simon A.L., Chan D.T.M., Hou E.F., Lewis J., Locatelli F., Praga M., Schena F.P., Levey A.S., Inker L.A. and Chronic Kidney Disease Epidemiology Collaboration .., Change in albuminuria as a surrogate endpoint for progression of kidney disease: a meta-analysis of treatment effects in randomised clinical trials, The Lancet Diabetes & Endocrinology. 2019, 7(2): 128-139.
Lau G.K.K., Lau C.D., Chan D.T.M. and Tang S.C.W., 1962 Albert Lasker Basic Medical Resaerch Award – Choh Hao Li (Ch. 12)., Nobel and Lasker Laureates of Chinese Descent in Literature and Science, Edited by Todd S. Ing, Keith K. Lau, Joseph M. Chan, Hon-lok Tang and Angela T. Hadsell and Laurence K. Chan,. World Scientific, Singapore, 2019, 183-199.
Li C., Yap Y.H.D., Chan S.W.G., Wen Y., Li H., Tang S.O.C., Li X., Li X. and Chan D.T.M., Clinical Outcomes and Clinico-pathological Correlations in Lupus Nephritis with Kidney Biopsy Showing Thrombotic Microangiopathy, The Journal of Rheumatology. 2019, jrheum.180773.
Li S., Ip K.M., Tang Y.H., Tang K.S., Tong Y., Zhang J., Hassan A.A., Mak A.S.C., Yung S.S.Y., Chan D.T.M., Ip P.C.P., Lee C.L., Chiu C.N., Lee L.T.O., Lai H.C., Zeng J.Z., Shum H.C. and Wong A.S.T., Sialyl LewisX-P-selectin cascade mediates tumor-mesothelial adhesion in ascitic fluid shear flow, Nat Cummun. 2019, 10(1): 2406.
Lui S.L., Yap Y.H.D., Cheng C.C.V., Chan D.T.M. and Yuen K.Y., Clinical practice guidelines for the provision of renal service in Hong Kong: Infection Control in Renal Service, Nephrology. 2019, 24 Suppl 1: 98-129.
Mackay M., Dali'Era M., Fishbein J., Kalunian K., Lesser M., Sanchez-Guerrero J., Levy D.M., Silverman E., Petri M., Arriens C., Lewis E.J., Korbet S.M., Conti F., Tesar V., Hruskova Z., Borba E.F., Bonfa E., Chan D.T.M., Rathi M., Gupta K.L., Jha V., Hasni S., West M.R., Solomons N., Houssiau F.A., Romero-Diaz J., Mejia-Vilet J. and Rovin B.H., Establishing Surrogate Kidney End Points for Lupus Nephritis Clinical Trials: Development and Validation of a Novel Approach to Predict Future Kidney Outcomes, Arthritis & Rheumatology. 2019, 71(3): 411-419.
Mok M.Y.M., Liu C.K., Lam M.F., Chan G.C., Ma K.M.M., Yap Y.H.D., Chiu F., Choy C.B., Tang S.C. and Chan D.T.M., A LONGITUDINAL STUDY ON THE PREVALENCE AND RISK FACTORS FOR DEPRESSION AND ANXIETY, QUALITY OF LIFE, AND CLINICAL OUTCOMES IN INCIDENT PERITONEAL DIALYSIS PATIENTS, Perit Dial Int.. 2018.
Shea Y.F., Lee M.C., Mok M.Y., Lam M.F., Chu L.W., Chan H.W.F. and Chan D.T.M., Self-Care Peritoneal Dialysis Patients with Cognitive Impairment Have a Higher Risk of Peritonitis in the Second Year, Peritoneal Dialysis International. 2019, 39(1): 51-58.
Thong K.M. and Chan D.T.M., Infectious complications in lupus nephritis treatment: a systematic review and meta-analysis, Lupus. 2019, 28(3): 334-346.
Wong C.K.H., Chen J.Y., Fung S.K.S., Mok M.Y., Cheng Y.L., Kong I., Lo W.K., Lui S.L., Chan D.T.M. and Lam C.L.K., Direct and indirect costs of end-stage renal disease patients in the first and second years after initiation of nocturnal home haemodialysis, hospital haemodialysis and peritoneal dialysis, Nephrology Dialysis Transplantation. 2018.
Wu M., Chen Y., Au T.W.K., Chan D., Sit K.Y., Ho K.L., Ho L.M., Lam Y.M., Lau C.P., Chan D.T.M., Tse H.F. and Yiu K.H., Predictive value of acute kidney injury for major adverse cardiovascular events following tricuspid annuloplasty: A comparison of three consensus criteria, Journal of Cardiology. 2018, 72: 247-254.
YU J., Yung S.S.Y., Chan C.Y.C., Chau K.M. and Chan D.T.M., Gut-derived lipopolysaccharide contributes to pathogenesis of lupus nephritis, ISN World Congress of Nephrology 2019.
Yap Y.H.D., Tang S.O.C., Chan G.C.W., Kwan P.Y.L., Ma K.M.M., Mok M.Y. and Chan D.T.M., Longterm Data on Sirolimus Treatment in Patients with Lupus Nephritis, The Journal of Rheumatology. 2018, 45(12): 1663-1670.
Yap Y.H.D., Yung S.S.Y. and Chan D.T.M., Lupus nephritis: An update on treatments and pathogenesis, Nephrology. 2018, 23 (Suppl 4): 80-83.
Yap Y.H.D., Tam C.H., Yung S.S.Y., Wong S., Tang S.O.C., Mok M.Y.T., Yuen C.K.Y., Ma M.K.M., Lau W.C.S. and Chan D.T.M., Pharmacokinetics and pharmacogenomics of mycophenolic acid and its clinical correlations in maintenance immunosuppression for lupus nephritis, Nephrol Dial Transplant. 2018.
Yap Y.H.D., Tam C.H., Yung S.S.Y., Wong S., Tang S.O.C., Mok M.Y.T., Yuen K.Y.C., Ma K.M.M., Lau W.C.S. and Chan D.T.M., Pharmacokinetics and pharmacogenomics of mycophenolic acid and its clinical correlations in maintenance immunosuppression for lupus nephritis, Nephrology Dialysis Transplantation. 2018.
Yung S.S.Y., Yu K., Chau K.M., Cheung K.F. and Chan D.T.M., Clinical associations with serum syndecan-1 level in patients with lupus nephritis, American Society of Nephrology Kidney Week 2018.
Yung S.S.Y., Yap Y.H.D. and Chan D.T.M., Chapter 5 “狼疮性肾炎的转化研究及新进展”, in, 腎脏疾病的转化医学研究和临床实践, 转化医学出版工程,“十三五” 倪兆慧, Claudio Ronco, 牟姗, Simon Davies, Tak Mao Chan, Editors. 国家重点图书出版规划项目, 上海科技专著出版资金资助项目, 2019.


Researcher : Chan GCW

List of Research Outputs

Chan K.W., Kwong A.S.K., Chan G.C.W., Leung C.P.S., Yiu W.H., Lui S.L., Ip T.P., Cowling B.J., Wong W.L.D., LI B., LI Y., Feng Y., Chan L.Y.Y., Leung J.C.K., Tan K.C.B., Wong C.W.V., Lai K.N. and Tang S.C.W., Best Poster Award, Good Practice In Traditional Chinese Medicine Research Association. 2018.
Chan K.W., Kwong A.S.K., Chan G.C.W., Leung C.P.S., Yiu W.H., Lui S.L., Ip T.P., Cowling B.J., Wong W.L.D., LI B., LI Y., Feng Y., Chan Y.Y., Leung J.C.K., Tan K.C.B., Wong C.W.V., Lai K.N. and Tang S.C.W., Semi-individualised Chinese Medicine Treatment for Diabetic Kidney Disease – From users’ perspectives to SCHEMATIC trial interim result and potential mechanisms, Advances in Integrative Medicine (International Congress on Complementary Medicine Research). 2019, 6: S12.
Yap Y.H.D., Tang S.O.C., Chan G.C.W., Kwan P.Y.L., Ma K.M.M., Mok M.Y. and Chan D.T.M., Longterm Data on Sirolimus Treatment in Patients with Lupus Nephritis, The Journal of Rheumatology. 2018, 45(12): 1663-1670.


Researcher : Chan HHL

Project Title:The role of epidermal cooling in improving the outcome of laser therapy in the treatment of Nevus of Ota
Investigator(s):Chan HLH, Lam LK
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:12/2000


Project Title:The use of vascular lasers in the treatment of port wine stain in chinese
Investigator(s):Chan HLH, Wei WI
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:11/2001


List of Research Outputs



Researcher : Chan HLH

Project Title:The role of epidermal cooling in improving the outcome of laser therapy in the treatment of Nevus of Ota
Investigator(s):Chan HLH, Lam LK
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:12/2000


Project Title:The use of vascular lasers in the treatment of port wine stain in chinese
Investigator(s):Chan HLH, Wei WI
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:11/2001


List of Research Outputs

Chan W.M.M., Shek Y.N.S., Yeung C.K. and Chan H.L.H., A prospective study in the treatment of lentigines in Asian skin using 532 nm picosecond Nd: YAG laser. , In: Brian Wong, Lasers in Surgery and Medicine. Lasers in Surgery and Medicine, 2019.
Wang H.L., Chan H.L.H., Ni M.Y., Lam W.W.T., Chan W.M.M. and Pang H.M.H., Bacteriophage of the Skin Microbiome in Patients with Psoriasis and Healthy Family Controls, In: Mark C. Udey, Journal of Investigative Dermatology. 2019.


Researcher : Chan HWF

List of Research Outputs

Shea Y.F., Lee M.C., Mok M.Y., Lam M.F., Chu L.W., Chan H.W.F. and Chan D.T.M., Self-Care Peritoneal Dialysis Patients with Cognitive Impairment Have a Higher Risk of Peritonitis in the Second Year, Peritoneal Dialysis International. 2019, 39(1): 51-58.
Wong T.M., Fang C.X., Lau T.W., Chan H.W.F., Leung F.K.L. and Wu J., Effectiveness of a Day Rehabilitation Program in Improving Functional Outcome and Reducing Mortality and Readmission of Elderly Patients With Fragility Hip Fractures, 4th AOTrauma Asia Pacific Scientific Congress. 2019.


Researcher : Chan JCK

Project Title:Application of the APACHE II and III prognostic scoring methods in the 14-bed Intensive Care Unit at Queen Mary Hospital
Investigator(s):Chan JCK, Lam WK
Department:Medicine
Source(s) of Funding:Health Services Research Fund - Full Grants
Start Date:07/1995




Researcher : Chan KH

Project Title:Clinical outcome of multiple sclerosis in Hong Kong Chinese
Investigator(s):Chan KH
Department:Medicine
Source(s) of Funding:Bayer Pharmaceuticals Ltd. - General Award
Start Date:01/2008


Project Title:Study of clinical and immunological characteristics of local multiple sclerosis patients
Investigator(s):Chan KH, Ho SL
Department:Medicine
Source(s) of Funding:Bayer Pharmaceuticals Ltd. - General Award
Start Date:03/2008


Project Title:The role of Interleukin-17 a nd Interleukin-23 and magnetic resonance findings during relapse of multiple sclerosis and neuromyelitis optica
Investigator(s):Chan KH, Ho WL
Department:Medicine
Source(s) of Funding:Bayer Pharmaceuticals Ltd. - General Award
Start Date:04/2009


Project Title:Study of potential neuroprotective role of adiponectin and APPL1 in beta-amyloid neurotoxicity
Investigator(s):Chan KH, Lam KSL, Xu A, Ho SL, Ho WL
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:02/2010


Project Title:Study of immunopathogenesis of multiple sclerosis and neuromyelitis optica
Investigator(s):Chan KH, Ho WL
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:06/2011


Project Title:Investigation of adiponectin gene therapy in an animal model of Alzheimer's disease
Investigator(s):Chan KH, Ng CL, Chung SK
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:08/2016
Completion Date:08/2019


Project Title:Longitudinal MRI Study of local multiple sclerosis patients using quantitative conventional MRI and advanced MRI techniques
Investigator(s):Chan KH
Department:Medicine
Source(s) of Funding:Novartis Pharmaceuticals (HK) Ltd
Start Date:01/2017


Project Title:Research for effective treatments for Alzhimer's disease
Investigator(s):Chan KH, Chung SK
Department:Medicine
Source(s) of Funding:Chan Kin Shing Charitable Trust
Start Date:10/2017


Project Title:Myeloperoxidase Inhibition ameliorates neuroinflammation in Alzheimer’s disease
Investigator(s):Chan KH, Ng CL
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:04/2018


Project Title:Advanced neuroimaging modalities and clinical correlates in multiple sclerosis and neuromyelitis optica spectrum disorders
Investigator(s):Chan KH, Mak HKF
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:08/2018


Project Title:Effects of pioglitazone on the time course of astrocytopathy and microglial activation in mice received aquaporin-4 autoantibodies from patients with neuromyelitis optica spectrum disorders
Investigator(s):Chan KH, Yick LW
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:01/2019


List of Research Outputs

Chan K.H., Diseaese Modifying Drugs (DMD) for Mutliple Sclerosis (MS): Optimization of Benefits and Personalization, Annual Scientific Meeting of the Macao Neuro-medical Society 2019. 2019.
Chan K.H., Immunopathology of MS: Role of B & T cell, 1st MS Expert Meeting, Taipei,July 2018. 2018.
Chan K.H. and Yick L.W., Memantine and pioglitazone ameliorate motor impairments and complement-independent cord pathologies in mice received aquaporin-4 autoantibodies from neuromyelitis optica spectrum disorder (NMOSD) patients, 11th Congress of the Pan-Asian Committee for Treatment and Research in Multiple Sclerosis 2018, Sydney. 2018.
Chan K.H., Publication Award, Department of Medicine, LKS Faculty of Medicine, HKU. 2018.
Chan K.H., Publication Award, Department of Medicine, LKS Faculty of Medicine, The University of Hong Kong. 2019.
Chan K.H., Therapeutic effects of adiponectin in an animal model of Alzheimer's disease, International Alzheimer's Disease Conference 2019. Hong Kong, May 2019. 2019.
Cheung S.S.L., Lau G.K.K., Chan K.H., Wong Y.H.I., Lai J.S.M., Tang W.K. and Shih K.C., Optic neuritis as the initial clinical presentation of limbic encephalitis: a case report, Journal of Medical Case Reports. 2018.
JIAN M., Kwan S.C., Bunting M., Ng C.L. and Chan K.H., Adiponectin suppresses amyloid-beta oligomer (AbO)-induced inflammatory response of microglia via AdipoR1-AMPK-NF-kB signaling pathway, Journal of Neuroinflammation. 2019, 16: 110.
Jian M., Ng C.L. and Chan K.H., Adiponectin attenuates microglia-mediated neuroinflammation and modulates microglia phagocytosis in Alzheimer’s Disease, 14th International Conference on Alzheimer's & Parkinson's Diseases. 2019, Lisbon. 2019.
Ma K.F.O., Ng C.L., Yick L.W., Jian M. and Chan K.H., In vivo electroporation-mediated transfer of interleukin-35 gene decreases demyelination in animal model of multiple sclerosis, 24th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2019, ;25(1)(Supplement 1): 32.
Ng C.L., Jian M., Bunting M., Ma K.F.O., Chung S.K. and Chan K.H., Adiponectin deficiency exacerbated neuropathologenesis and cognitive functions in Alzheimer’s disease mice: potential application of AdipoRon as Alzheimer’s disease treatment, 24th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2019, 25(1)(Supplement 1): 35.
Ng C.L., Jian M., Ma K.F.O. and Chan K.H., Adiponectin deficiency exacerbated vasculo-neuronal dysfunction and degeneration in Alzheimer’s disease mice model, 14th International Conference on Alzheimer's and Parkinson's Disease. 2019, Lisbon. 2019.
Yick L.W. and Chan K.H., Memantine and pioglitazone ameliorate motor impairments and spinal cord pathologies in mice received aquaporin-4 autoantibodies from patients with neuromyelitis optica spectrum disorders, 24th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2019, 25(1)(Supplement 1).


Researcher : Chan KW

List of Research Outputs

Chan K.W., Kwong A.S.K., Chan G.C.W., Leung C.P.S., Yiu W.H., Lui S.L., Ip T.P., Cowling B.J., Wong W.L.D., LI B., LI Y., Feng Y., Chan L.Y.Y., Leung J.C.K., Tan K.C.B., Wong C.W.V., Lai K.N. and Tang S.C.W., Best Poster Award, Good Practice In Traditional Chinese Medicine Research Association. 2018.
Chan K.W., Diagnosis, patient expectations, evidence and cases of Diabetic Kidney Disease, Professional Advancement Series 2018, Hong Kong Association of Traditional Chinese Medicine. Hong Kong, 2018.
Chan K.W., Integrative management for diabetic kidney disease: Patients’ and clinicians’ perspectives, clinical effectiveness and possible mechanisms, The University of Hong Kong. 2018.
Chan K.W., Kwong A.S.K., Chan G.C.W., Leung C.P.S., Yiu W.H., Lui S.L., Ip T.P., Cowling B.J., Wong W.L.D., LI B., LI Y., Feng Y., Chan Y.Y., Leung J.C.K., Tan K.C.B., Wong C.W.V., Lai K.N. and Tang S.C.W., Semi-individualised Chinese Medicine Treatment for Diabetic Kidney Disease – From users’ perspectives to SCHEMATIC trial interim result and potential mechanisms, Advances in Integrative Medicine (International Congress on Complementary Medicine Research). 2019, 6: S12.
LI B., Leung J.C.K., Chan Y.Y., Yiu W.H., LI Y., LOK W.Y., Liu W.H., Chan K.W., Tse H.F., Lai K.N. and Lai K.N., Amelioration of Endoplasmic Reticulum Stress by Mesenchymal Stem Cells Via Hepatocyte Growth Factor/c‐Met Signaling in Obesity‐Associated Kidney Injury, STEM CELLS Translational Medicine. 2019.


Researcher : Chan KWK

List of Research Outputs

Huang D., Cheng Y., Wong Y.T.A., Yung S.A., Tam C.C., Chan K.W.K., Lam C.C.S., Yiu K.H., Hai S.H.J.J., Lau C.P., Chan E.W.Y., Chiang C.E., Wong K.L., Cheung T.T., Cheung B.M.Y., Feng Y.Q., Tam N., Chen J.Y., Yue W.S., Hu H.X., Chen L., Tse H.F., Chan P.H.M. and Siu D.C.W., Thrombolysis in myocardial infarction risk score for secondary prevention of recurrent cardiovascular events in a real-world cohort of post-acute myocardial infarction patients, Circulation. 2019, 83(4): 809-817.


Researcher : Chan LY

List of Research Outputs

Chan L.Y. and Chung H.Y., Sulfasalazine-Induced Connective Tissue Disease, JCR: Journal of Clinical Rheumatology. 2019, 1.
LI B., Leung J.C.K., Chan L.Y., Yiu W.H., Lai K.N. and Tang S.C.W., Mesenchymal Stem Cells Derived from Induced Pluripotent Stem Cells and Bone Marrow Are Equally Effective in Ameliorating Lipotoxicity-Induced Kidney Injury (Conference Abstract)., J Am Soc Nephrol. 2018, 29: 284.
Yiu W.H., Wong D.W., LOK W.Y., Liu W.H., LI Y., CHAN L.Y., Leung J.C.K., Lan H.Y. and Tang S.C.W., The Long Noncoding RNA Meg3 Mediates TLR4–Induced Renal Inflammation in Experimental Obstructive Nephropathy (Conference Abstracts) , J Am Soc Nephrol . 2018, 29: 953.


Researcher : Chan MMW

Project Title:A surveillance program of tuberculosis in old age homes in Hong Kong
Investigator(s):Chan MMW, Chu LW, Lam WK
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:11/2001


Project Title:A surveillance program of tuberculosis in old age homes in Hong Kong
Investigator(s):Chan MMW, Chu LW, Lam WK
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:01/2004




Researcher : Chan PHM

Project Title:Comparative Evaluation of Combined Coronary Computed Tomography Angiography and Myocardial Perfusion Versus Cardiac Magnetic Resonance Imaging Myocardial Perfusion for Diagnosis of Coronary Artery Disease
Investigator(s):Chan PHM, She HLH, Tse HF, Chan WS, Siu DCW, Cheung CWS
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:07/2015
Completion Date:09/2019


Project Title:Provision of Free B-type Natriuretic Peptide Testing for Poor and Sick Patients with Fluid Overload to Improve Heart Failure Management
Investigator(s):Chan PHM, Siu DCW, Tse HF
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:01/2016


Project Title:Free computed tomography coronary angiography for poor and sick patients to evaluate for coronary artery disease
Investigator(s):Chan PHM, Ng MY, Tse HF
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:01/2016


Project Title:Provision of free non-vitamin K antagonist oral anticoagulants for poor and sick patients with atrial fibrillation who have high ischemic stroke risk
Investigator(s):Chan PHM, Siu DCW, Tse HF
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:01/2016


Project Title:Prospective evaluation of the impact of Drug-Coated Balloon in the management of true coronary bifurcation disease
Investigator(s):Chan PHM, Siu DCW, Tse HF
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:04/2017


Project Title:Screening Of Pulmonary Hypertension in systemic lupus Erythematosus: SOPHIE study
Investigator(s):Chan PHM, Siu DCW
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2018


List of Research Outputs

Huang D., Cheng Y., Wong Y.T.A., Yung S.A., Tam C.C., Chan K.W.K., Lam C.C.S., Yiu K.H., Hai S.H.J.J., Lau C.P., Chan E.W.Y., Chiang C.E., Wong K.L., Cheung T.T., Cheung B.M.Y., Feng Y.Q., Tam N., Chen J.Y., Yue W.S., Hu H.X., Chen L., Tse H.F., Chan P.H.M. and Siu D.C.W., Thrombolysis in myocardial infarction risk score for secondary prevention of recurrent cardiovascular events in a real-world cohort of post-acute myocardial infarction patients, Circulation. 2019, 83(4): 809-817.


Researcher : Chan SYT

List of Research Outputs

Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Mak L.Y., Wong D.K.H., Fung J.Y.Y., Liu S.H.K., Cheung K.S.M., Lai C.L., Kwong Y.L. and Yuen R.M.F., Monitoring and Treatment of Patients Undergoing Immunotherapy With Anti-CD20 Who are Exposed to HBV, Clinical Gastroenterology and Hepatology. 2018, 17(7): 1410-1412.
Singh G.H.H., Kumana C.R., Yim R.L.H., Hwang Y.Y.G., Chan S.Y.T., Yip S.F., Lee H.K.K., Mak V., Lau J.S.M., Chan C.C., Kho B., Wong R.S.M., Li W., Lin S.Y., Lau C.K., Ip H.W., Leung R.Y.Y., Lam C.C.K. and Kwong Y.L., Oral arsenic trioxide incorporation into frontline treatment with all‐trans retinoic acid and chemotherapy in newly diagnosed acute promyelocytic leukemia: A 5‐year prospective study, Cancer. 2019.


Researcher : Chan VNY

Project Title:Hepatitis B virus array for genotyping and mutation detection
Investigator(s):Chan VNY, Lai CL, Chan K, Yuen RMF
Department:Medicine
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:11/2006




Researcher : Chan VSF

Project Title:Regulation of inflammasome activation in systemic lupus erythematosus
Investigator(s):Chan VSF, Lau WCS
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2017


List of Research Outputs

CHOW J.X., Lam K.Y.I., Wong Y.Y.S., Lau W.C.S. and Chan V.S.F., Dysregulation of AIM2 inflammasome response in patients with Systemic Lupus Erythematosus, 13th World Immune Regulation Meeting. 2019.
Li Q., Wu H., Liao W., Zhao M., Chan V.S.F., Li L., Zheng M., Chen G., Zhang J., Lau W.C.S. and Lu Q., A comprehensive review of immune-mediated dermatopathology in systemic lupus erythematosus, Journal of Autoimmunity. 2018, 93: 1-15.
Sze S.Y., Chan V.S.F. and Lau W.C.S., Abnormal expression of long non-coding RNAs in systemic lupus erythematosus and lupus nephritis, 13th World Immune Regulation Meeting. 2019.
Wu H., Liao W., Li Q., Long H., Yin H., Zhao M., Chan V.S.F., Lau W.C.S. and Lu Q., Pathogenic role of tissue-resident memory T cells in autoimmune diseases, Autoimmunity Reviews. 2018, 17: 906-911.


Researcher : Chan WM

List of Research Outputs

Tsai N.W.P., Leung Y.M., Yeung P.N.P., Liong T.I.N.G., Lee S.F., Ngai C.W., Sin W.C., Koo J. and Chan W.M., Attitudes of visitors at adult intensive care unit toward organ donation and organ support, Chinese Medical Journal. 2019, 132: 373-376.


Researcher : Chan WMM

List of Research Outputs

Chan W.M.M., Shek Y.N.S., Yeung C.K. and Chan H.L.H., A prospective study in the treatment of lentigines in Asian skin using 532 nm picosecond Nd: YAG laser. , In: Brian Wong, Lasers in Surgery and Medicine. Lasers in Surgery and Medicine, 2019.
Wang H.L., Chan H.L.H., Ni M.Y., Lam W.W.T., Chan W.M.M. and Pang H.M.H., Bacteriophage of the Skin Microbiome in Patients with Psoriasis and Healthy Family Controls, In: Mark C. Udey, Journal of Investigative Dermatology. 2019.


Researcher : Chan WS

List of Research Outputs

Lui M.S.M., Tse H.F., Mak J.C.W., Lam C.L.D., Chan W.S., Chong W.C. and Ip M.S.M., Untreated Obstructive Sleep Apnea Is Associated With Myocardial Injury Independent of Blood Pressure Control in Hypertension, Journal of Clinical Sleep Medicine. 2018, 14: 1841-1847.


Researcher : Chan YY

List of Research Outputs

Chan K.W., Kwong A.S.K., Chan G.C.W., Leung C.P.S., Yiu W.H., Lui S.L., Ip T.P., Cowling B.J., Wong W.L.D., LI B., LI Y., Feng Y., Chan Y.Y., Leung J.C.K., Tan K.C.B., Wong C.W.V., Lai K.N. and Tang S.C.W., Semi-individualised Chinese Medicine Treatment for Diabetic Kidney Disease – From users’ perspectives to SCHEMATIC trial interim result and potential mechanisms, Advances in Integrative Medicine (International Congress on Complementary Medicine Research). 2019, 6: S12.
LI B., Leung J.C.K., Chan Y.Y., Yiu W.H., LI Y., LOK W.Y., Liu W.H., Chan K.W., Tse H.F., Lai K.N. and Lai K.N., Amelioration of Endoplasmic Reticulum Stress by Mesenchymal Stem Cells Via Hepatocyte Growth Factor/c‐Met Signaling in Obesity‐Associated Kidney Injury, STEM CELLS Translational Medicine. 2019.


Researcher : Chau KM

List of Research Outputs

Chan D.T.M., Ho S., Tai C.P., Chan C.Y.C., Chau K.M. and Yung S.S.Y., Anti-dsDNA antibodies bind to Ku70 in proximal renal tubular epithelial cells and increase matrix protein synthesis and MCP-1 secretion, ISN World Congress of Nephrology 2019.
Chan D.T.M., Ho S.S.K., Tai C.P., Chan C.Y.C., Cheng W.M., Chau K.M. and Yung S.S.Y., Anti-dsDNA antibodies bind to Ku70 in proximal renal tubular epithelial cells and increased matrix protein and cytokine secretion, American Society of Nephrology Kidney Week 2018.
YU J., Yung S.S.Y., Chan C.Y.C., Chau K.M. and Chan D.T.M., Gut-derived lipopolysaccharide contributes to pathogenesis of lupus nephritis, ISN World Congress of Nephrology 2019.
Yung S.S.Y., Yu K., Chau K.M., Cheung K.F. and Chan D.T.M., Clinical associations with serum syndecan-1 level in patients with lupus nephritis, American Society of Nephrology Kidney Week 2018.


Researcher : Chen L

List of Research Outputs

Cheung K.S.M., Chen L., Seto W.K.W. and Leung W.K., Best Abstract Award in Clinical Medicine (oral presentation), 24th Medical Research Conference, Hong Kong, The University of Hong Kong . 2019.
Cheung K.S.M., Chen L., Seto W.K.W. and Leung W.K., Epidemiology, characteristics and survival of post-colonoscopy colorectal cancer in Hong Kong: a population-based study, Medical Research Conference. 2019.
Cheung K.S.M., Chen L., Seto W.K.W. and Leung W.K., Epidemiology, characteristics and survival of post‐colonoscopy colorectal cancer in Asia: a population‐based study, Journal of Gastroenterology and Hepatology. 2019.
Cheung K.S.M., Chan E.W., Wong A.Y., Chen L., Seto W.K.W., Wong I.C.K. and Leung W.K., Metformin Use and Gastric Cancer Risk in Diabetic Patients After Helicobacter pylori Eradication, JNCI: Journal of the National Cancer Institute. 2018.
Cheung K.S.M., Chan E.W.Y., Wong A.S.Y., Chen L., Seto W.K.W., Wong I.C.K. and Leung W.K., Statin use and gastric cancer risk in Helicobacter pylori-eradicated patients: a territory-wide study with propensity score matching, Medical Research Conference, Hong Kong. 2019.
Cheung K.S.M., Chen L., Chan E.W., Seto W.K.W., Wong I.C.K. and Leung W.K., Statins reduce the progression of non-advanced adenomas to colorectal cancer: a postcolonoscopy study in 187 897 patients, Gut. 2019, gutjnl-2018-317714.
Cheung K.S.M., Chan E.W.Y., Chen L., Seto W.K.W., Wong I.C.K. and Leung W.K., Use of non-aspirin non-steroidal anti-inflammatory drugs and risk of post-colonoscopy colorectal cancer: a territory-wide study with propensity score analysis, Digestive Disease Week . 2019.
GUO C., Cheung K.S.M., Zhang F., Chan E.W.Y., Chen L., Wong I.C.K. and Leung W.K., Incidences, temporal trends and risks of hospitalisation for gastrointestinal bleeding in new or chronic low-dose aspirin users after treatment for Helicobacter pylori : a territory-wide cohort study , Gut. 2019, gutjnl-2019-318352.
GUO C., Chen L., Chan E.W.Y., Cheung K.S.M., Isshiki T., Wong I.C.K. and Leung W.K., Systematic review with meta- analysis: the risk of gastrointestinal bleeding in patients taking third-generation P2Y12 inhibitors compared with clopidogrel, Alimentary Pharmacology & Therapeutics. 2019.
JIANG D., XIONG G., FENG H., ZHANG Z., Chen P., Yan B., CHEN L., Kesavamoorthy G., MA C.Y., Li C., HAN S., Zhang Y., Liao C., Lee T.L., Tse H.F., Fu Q.L., Chiu K. and Lian Q., Donation of mitochondria by iPSC-derived mesenchymal stem cells protects retinal ganglion cells against mitochondrial complex I defect-induced degeneration, Theranostics. Australia, Ivyspring International Publisher, 2019, 2019, Vol. 9, Issue 8: 2395-2410.
Leung W.K., Chen L., Seto W.K.W. and Cheung K.S.M., Characteristics and risk factors of post-colonoscopy interval cancers: a population-based study from Asia, Digestive Disease Week. 2019.


Researcher : Chen WH

Project Title:Enoxaparin combined with epitfibatide or abciximab versus unfractionated heparin combined with epitfibatide or abciximab in percutaneous coronary intervention: obersvations on efficacy, safety, anticoagulation profile, and level of platelet inhibition
Investigator(s):Chen WH, Lau CP
Department:Medicine
Source(s) of Funding:Other Funding Scheme
Start Date:06/2001


Project Title:A prospective study to investigate the determinants of the quantity of embolized debris during native vessel percutaneous coronary intervention
Investigator(s):Chen WH, Lau CP
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2002


Project Title:A prospective study to evaluate the relation between aspirin resistance and the incidence and magnitude of myonecrosis after percutaneous coronary intervention
Investigator(s):Chen WH, Lau CP
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2003




Researcher : Chen Y

List of Research Outputs

CHEN Y., Au T.W.K., Chan D., Sit K.Y., Zhen Z., Ho K.L., Wong D., Ho L.M., Yap Y.H.D., Lam Y.M., Lau C.P., Tse H.F., Chan D.T.M. and Yiu K.H., Clinical Benefit of Valvular Surgery in Patients with Chronic Kidney Disease, International Heart Journal. 2018, 59: 759-765.
CHEN Y., Liu Y., Seto W.K.W., Wu M., YU Y., Lam Y.M., Au W.K., Chan D., Sit K.Y., Ho L.M., Tse H.F. and Yiu K.H., Prognostic Value of Hepatorenal Function By Modified Model for End‐stage Liver Disease (MELD) Score in Patients Undergoing Tricuspid Annuloplasty, Journal of the American Heart Association. 2018, 7: e009020.
Chan Y.H., Ngai M.C., Chen Y., Wu M., YU Y., ZHEN Z., Lai K.W.H., Cheung T.T., Ho L.M., Chung H.Y., Lau W.C.S., Tse H.F. and Yiu K.H., Cumulative Rheumatic Inflammation Modulates the Bone–Vascular Axis and Risk of Coronary Calcification, Journal of the American Heart Association. 2019, 8.
Chan Y.H., Ngai M.C., Chen Y., Wu M., YU Y., ZHEN Z., Lai K.W.H., Cheung T.T., Ho L.M., Chung H.Y., Lau W.C.S., Lau C.P., Tse H.F. and Yiu K.H., Osteogenic circulating endothelial progenitor cells are linked to electrocardiographic conduction abnormalities in rheumatic patients, Annals of Noninvasive Electrocardiology. 2019, e12651.
Chen Y., Au T.W.K., Chan D., Sit K.Y., Zhen Z., Ho K.L., Wong D., Ho L.M., Yap Y.H.D., Lam Y.M., Lau C.P., Tse H.F., Chan D.T.M. and Yiu K.H., Clinical Benefit of Valvular Surgery in Patients with Chronic Kidney Disease. , International heart journal. 2018, 59(4): 759-765.
Chen Y., Liu Y., Seto W.K.W., Wu M., YU Y., Lam Y.M., Au T.W.K., Sit K.Y., Ho L.M., Tse H.F. and Yiu K.H., Prognostic Value of Hepatorenal Function By Modified Model for End-stage Liver Disease (MELD) Score in Patients Undergoing Tricuspid Annuloplasty, Journal of the American Heart Association. 2018, 7(14): 1-11.
Chen Y., Liu Y., Wu M., Lam Y.M., Ho L.M., Lau C.P., Au T.W.K., Tse H.F. and Yiu K.H., Prognostic value of tricuspid valve geometry and leaflet coaptation status in patients undergoing tricuspid annuloplasty: a three-dimensional echocardiography study, PCR Tokyo Valves 2019.
Wu M., Chen Y., Au T.W.K., Chan D., Sit K.Y., Ho K.L., Ho L.M., Lam Y.M., Lau C.P., Chan D.T.M., Tse H.F. and Yiu K.H., Predictive value of acute kidney injury for major adverse cardiovascular events following tricuspid annuloplasty: A comparison of three consensus criteria, Journal of Cardiology. 2018, 72: 247-254.


Researcher : Cheng CTK

List of Research Outputs

Yuen R.M.F., Liu S.H.K., Seto W.K.W., Wong D.K.H., Wong S.Y., Cheung K.S.M., Mak L.Y.L., Ko K.L.M., To W.P.E., Yuen J.C.H., Wu C.H., Cheng C.T.K., Wu J.T.K. and Lau E.H.Y., Faculty Knowledge Exchange Award, HKU LKS Faculty of Medicine. 2019.


Researcher : Cheng CW

List of Research Outputs

Cheng C.W. and Tse E.W.C., PIN1 in Cell Cycle Control and Cancer, Frontiers in Pharmacology. 2018, 9.


Researcher : Cheng CYS

List of Research Outputs

Wong D.K.H., Cheng C.Y.S., Mak L.Y., To W.P., Lo C.L.R., Cheung T.T., Seto W.K.W., Fung J.Y.Y., Man K., Lai C.L. and Yuen R.M.F., Among Patients with Undetectable Hepatitis B Surface Antigen and Hepatocellular Carcinoma, a High Proportion Has Integration of HBV DNA into Hepatocyte DNA and No Cirrhosis, Clinical Gastroenterology and Hepatology. 2019.
Wong D.K.H., Cheng C.Y.S., Mak L.Y., To W.P., Cheung T.T., Seto W.K.W., Fung J.Y.Y., Man K., Lai C.L. and Yuen R.M.F., High Rate of HBV DNA Integration in Hepatocellular Carcinoma Patients with Occult Hepatitis B Infection, HEPATOLOGY. WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2018, 68: 331A-331A.
Wong D.K.H., Cheng C.Y.S., Mak L.Y., To W.P., Cheung T.T., Seto W.K.W., Fung J.Y.Y., Man K., Lai C.L. and Yuen R.M.F., Integration of HBV DNA near cancer-related genes in HBsAg-negative hepatocellular carcinoma patients, JOURNAL OF HEPATOLOGY. ELSEVIER SCIENCE BV PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, 2019, 70: E269-E269.


Researcher : Cheng KY

Project Title:The adaptor protein APPL2 as a physiological modulator of pancreatic β-cell functions in mice
Investigator(s):Cheng KY, Cheung YY
Department:Medicine
Source(s) of Funding:National Natural Science Foundation of China (NSFC) - General Program
Start Date:01/2015


Project Title:Hypothalamic APPL2 combats against obesity by promoting adaptive thermogenesis in adipose tissues
Investigator(s):Cheng KY, Xu A
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:04/2015


Project Title:APPL2 as a key mediator of white-to-beige fat transdifferentiation
Investigator(s):Cheng KY, Xu A
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:06/2015


Project Title:The role of adipocyte turnover in regulation of systemic energy and glucose homeostasis
Investigator(s):Cheng KY, Xu A
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:06/2016


List of Research Outputs

Gao C., Chen X., Xu A., Cheng K.Y. and Shen J., Adaptor Protein APPL2 Affects Adult Antidepressant Behaviors and Hippocampal Neurogenesis via Regulating the Sensitivity of Glucocorticoid Receptor, Molecular Neurobiology. 2018, 55: 5537-5547.


Researcher : Cheng WM

List of Research Outputs

Chan D.T.M., Ho S.S.K., Tai C.P., Chan C.Y.C., Cheng W.M., Chau K.M. and Yung S.S.Y., Anti-dsDNA antibodies bind to Ku70 in proximal renal tubular epithelial cells and increased matrix protein and cytokine secretion, American Society of Nephrology Kidney Week 2018.


Researcher : Cheng Y

List of Research Outputs

Huang D., Cheng Y., Wong Y.T.A., Yung S.A., Tam C.C., Chan K.W.K., Lam C.C.S., Yiu K.H., Hai S.H.J.J., Lau C.P., Chan E.W.Y., Chiang C.E., Wong K.L., Cheung T.T., Cheung B.M.Y., Feng Y.Q., Tam N., Chen J.Y., Yue W.S., Hu H.X., Chen L., Tse H.F., Chan P.H.M. and Siu D.C.W., Thrombolysis in myocardial infarction risk score for secondary prevention of recurrent cardiovascular events in a real-world cohort of post-acute myocardial infarction patients, Circulation. 2019, 83(4): 809-817.


Researcher : Cheng YY

Project Title:The role of hypoxia inducible factor 1 alpha in NK/T-cell lymphoma
Investigator(s):Cheng YY, Tse EWC
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:12/2008




Researcher : Cheung BMY

Project Title:Accelerating the Development of Pharmacogenomics at HKU through a Systems Biology Approach
Investigator(s):Cheung BMY
Department:Medicine
Source(s) of Funding:Innovative Research Grants
Start Date:07/2013


Project Title:The 10th Scientific Conference on Cardiovascular Science Across the Strait
Investigator(s):Cheung BMY
Department:Medicine
Source(s) of Funding:Croucher Foundation - Conference / Seminars
Start Date:11/2015


Project Title:British and Irish Hypertension Society Annual Scientific Meeting; Characteristics of Americans with Stage 1 Hypertension: United States National Health Nutrition and Examination Survey (NHANES) 2011-2016
Investigator(s):Cheung BMY
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:09/2018
Completion Date:09/2018


Project Title:Novel biomarkers of mortality and adverse outcomes for patients with acute coronary syndrome
Investigator(s):Cheung BMY, Cheung CL, Tam CC, Xu A
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:06/2019


List of Research Outputs

Chan E.W. and Cheung B.M.Y., Ethnic differences in response to cardiovascular drugs, In: European Society of Cardiology, The ESC textbook of cardiovascular medicine (3rd Edition). 2018.
Chan S.L.Y., TSOI M.F., Cheung T.T. and Cheung B.M.Y., Stroke incidence in Hong Kong after recall of contaminated generic valsartan, 24th Medical Research Conference. Hong Kong, Hong Kong Medical Journal, 2019, 25 (1), supp 1: 9.
Cheung B.M.Y. and Yau H.K.C., Clinical Therapeutics in Hong Kong, Clinical Therapeutics. 2019, 41: 592-597.
Cheung B.M.Y. and Lam K.S.L., Never too old for statin treatment?, The Lancet. 2019, 393: 379-380.
Cheung C.L., Tan K.C.B., Au C.M., Li H.Y. and Cheung B.M.Y., Evaluation of GDF15 as a therapeutic target of cardiometabolic diseases in human: A Mendelian randomization study, EBioMedicine. 2019, 41: 85-90.
Cheung T.T., Chiu W.Y.J., Yuen R.M.F., Lam K.S.L., Cheung B.M.Y., Feng H.P., Yeh W.W., Wang J.D., Li W.T., Zhao X.M., Wang Z.Q. and Mu S.M., A Phase I, Single- and Multiple-dose Study to Evaluate the Pharmacokinetics of Elbasvir and Grazoprevir in Healthy Chinese Participants” [Clinical Therapeutics 40 (2018) 719–732], Clinical Therapeutics. 2018, 40: 719-732.
Cheung T.T., TSOI M.F., Cheung B.M.Y. and Lau W.C.S., Mortality and causes of death in inflammatory arthritis patients in Hong Kong 1997-2016, 24th Medical Research Conference. Hong Kong, Hong Kong Medical Journal, 2019, 25 (1), supp 1: 13.
FEI Y., TSOI M.F. and Cheung B.M.Y., Cardiovascular outcomes in trials of new antidiabetic drug classes: a network meta-analysis, 24th Medical Research Conference. Hong Kong, Hong Kong Medical Journal, 2019, 25 (1), supp 1: 17.
FEI Y., TSOI M.F. and Cheung B.M.Y., Determining the Optimal Systolic Blood Pressure for Hypertensive Patients: A Network Meta-analysis, Canadian Journal of Cardiology. 2018, 34: 1581-1589.
FEI Y., LAM C.K. and Cheung B.M.Y., Efficacy and safety of newer P2Y12 inhibitors versus clopidogrel in patients with acute coronary syndrome, 24th Medical Research Conference. Hong Kong, Hong Kong Medical Journal, 2019, 25 (1), supp 1: 17.
FEI Y., TSOI M.F. and Cheung B.M.Y., Optimal duration of dual antiplatelet therapy after drug-eluting stent implantation: a network meta-analysis, 24th Medical Research Conference. Hong Kong, Hong Kong Medical Journal, 2019, 25 (1), supp 1: 18.
Huang D., Cheng Y., Wong Y.T.A., Yung S.A., Tam C.C., Chan K.W.K., Lam C.C.S., Yiu K.H., Hai S.H.J.J., Lau C.P., Chan E.W.Y., Chiang C.E., Wong K.L., Cheung T.T., Cheung B.M.Y., Feng Y.Q., Tam N., Chen J.Y., Yue W.S., Hu H.X., Chen L., Tse H.F., Chan P.H.M. and Siu D.C.W., Thrombolysis in myocardial infarction risk score for secondary prevention of recurrent cardiovascular events in a real-world cohort of post-acute myocardial infarction patients, Circulation. 2019, 83(4): 809-817.
Lee C.H.P., Chan R.S.M., Wan Y., Woo Y.C., Cheung Y.Y., Fong H.Y., Cheung B.M.Y., Lam T.H., Janus E., Woo J. and Lam K.S.L., Dietary Intake of Anti-Oxidant Vitamins A, C, and E Is Inversely Associated with Adverse Cardiovascular Outcomes in Chinese—A 22-Years Population-Based Prospective Study, Nutrients. 2018, 10: 1664.
Leung R.Y.H., Cheung B.M.Y., Tan K.C.B., Kung A.W.C. and Cheung C.L., 25-Hydroxyvitamin D and the risk of incident diabetes in Hong Kong Chinese, Public Health Nutrition. 2019, 1-7.
Leung R.Y.H., Li H.Y., Cheung B.M.Y., Tan K.C.B., Kung A.W.C. and Cheung C.L., Serum metabolomic profiling and its association with 25-hydroxyvitamin D, Clinical Nutrition. 2019.
Lui K.W.K., TSOI M.F., Cheung T.T., Cheung C.L. and Cheung B.M.Y., Are blood lead levels in the United States still declining? The United States National Health Nutrition and Examination Survey 1999-2016, 24th Medical Research Conference. Hong Kong, Hong Kong Medical Journal, 2019, 25(1) suppl 1: 30.
Ren L., Li C., Li W., Zeng Y., Ye S., Li Z., Feng H., Lei Z., Cai J., Hu S., Sui Y., Liu Q. and Cheung B.M.Y., Fast-tracking acute stroke care in China: Shenzhen Stroke Emergency Map, Postgraduate Medical Journal. 2019, 95: 46-47.
So A.S.C., TSOI M.F., Cheung C.L., Lee S.W., Tsui S.H., Tam C.C. and Cheung B.M.Y., Serum beta-2 microglobulin predicts mortality after acute coronary syndrome, 24th Medical Research Confernece. Hong Kong, Hong Kong Medical Journal, 2019, 25 (1), supp 1: 38.
TSOI M.F., Cheung B.M.Y., Lau W.C.S. and Cheung T.T., Association between blood lead level and gout: the United States National Health Nutrition and Examination Survey 2007-2014, 24th Medical Research Conference. Hong Kong, Hong Kong Medical Journal, 2019, 25 (1), supp 1: 39.
TSOI M.F., LUI K.K.W., Cheung T.T. and Cheung B.M.Y., Association between blood lead level and hypertension: the United States National Health Nutrition and Examination Survey 1999-2006, 24th Medical Research Conference. Hong Kong, Hong Kong Medical Journal, 2019, 25 (1), supp 1: 40.
TSOI M.F., Cheung T.T. and Cheung B.M.Y., Hyperlipidaemic effect of Janus kinase inhibitors: a meta-analysis, 24th Medical Research Conference. Hong Kong, Hong Kong Medical Journal, 2019, 25 (1), supp 1: 40.
TSOI M.F., Cheung B.M.Y., Lau W.C.S. and Cheung T.T., Incidence, prevalence, and utilisation of urate-lowering therapy in Hong Kong: a population-based study, 24th Medical Research Conference. Hong Kong, Hong Kong Medical Journal, 2019, 25 (1), supp 1: 41.
Wong Y.K., Cheung Y.Y., Tang S.M., Au K.W., Hai S.H.J.J., Lee C.H.P., Lau G.K.K., Cheung B.M.Y., Sham P.C., Xu A., Lam K.S.L. and Tse H.F., Age-Biomarkers-Clinical Risk Factors for Prediction of Cardiovascular Events in Patients With Coronary Artery Disease., Arterioscler Thromb Vasc Biol. American Heart Association, Inc., 2018, 38: 2519-2527.


Researcher : Cheung KF

List of Research Outputs

Yung S.S.Y., Yu K., Chau K.M., Cheung K.F. and Chan D.T.M., Clinical associations with serum syndecan-1 level in patients with lupus nephritis, American Society of Nephrology Kidney Week 2018.


Researcher : Cheung KS

List of Research Outputs



Researcher : Cheung KSM

List of Research Outputs

Cheung K.S.M., Leung W.K. and Seto W.K.W., Application of Big Data analysis in gastrointestinal research, World Journal of Gastroenterology. 2019, 25: 2990-3008.
Cheung K.S.M., Chen L., Seto W.K.W. and Leung W.K., Best Abstract Award in Clinical Medicine (oral presentation), 24th Medical Research Conference, Hong Kong, The University of Hong Kong . 2019.
Cheung K.S.M., Chen L., Seto W.K.W. and Leung W.K., Epidemiology, characteristics and survival of post-colonoscopy colorectal cancer in Hong Kong: a population-based study, Medical Research Conference. 2019.
Cheung K.S.M., Chen L., Seto W.K.W. and Leung W.K., Epidemiology, characteristics and survival of post‐colonoscopy colorectal cancer in Asia: a population‐based study, Journal of Gastroenterology and Hepatology. 2019.
Cheung K.S.M. and Leung W.K., Long-term use of proton-pump inhibitors and risk of gastric cancer: a review of the current evidence, Therapeutic Advances in Gastroenterology. 2019, 12: 175628481983451.
Cheung K.S.M., Chan E.W., Wong A.Y., Chen L., Seto W.K.W., Wong I.C.K. and Leung W.K., Metformin Use and Gastric Cancer Risk in Diabetic Patients After Helicobacter pylori Eradication, JNCI: Journal of the National Cancer Institute. 2018.
Cheung K.S.M. and Leung W.K., Response to Khosrow-Khavar, Kurteva, and Douros, JNCI: Journal of the National Cancer Institute. 2019.
Cheung K.S.M. and Leung W.K., Response to letter to the editor by Moayyedi et al , Gut. 2018, gutjnl-2018-317127.
Cheung K.S.M., Scientific accomplishment as an Early Career Investigator for Gastrointestinal Oncology (GIONC) Distinguished Abstract Plenary-Speaker Presentation, 50th Digestive Disease Week, San Diego, United States, American Gastroenterology Association . 2019.
Cheung K.S.M., Chan E.W.Y., Wong A.S.Y., Chen L., Seto W.K.W., Wong I.C.K. and Leung W.K., Statin use and gastric cancer risk in Helicobacter pylori-eradicated patients: a territory-wide study with propensity score matching, Medical Research Conference, Hong Kong. 2019.
Cheung K.S.M., Chen L., Chan E.W., Seto W.K.W., Wong I.C.K. and Leung W.K., Statins reduce the progression of non-advanced adenomas to colorectal cancer: a postcolonoscopy study in 187 897 patients, Gut. 2019, gutjnl-2018-317714.
Cheung K.S.M., Chan E.W.Y., Chen L., Seto W.K.W., Wong I.C.K. and Leung W.K., Use of non-aspirin non-steroidal anti-inflammatory drugs and risk of post-colonoscopy colorectal cancer: a territory-wide study with propensity score analysis, Digestive Disease Week . 2019.
GUO C., Cheung K.S.M., Zhang F., Chan E.W.Y., Chen L., Wong I.C.K. and Leung W.K., Incidences, temporal trends and risks of hospitalisation for gastrointestinal bleeding in new or chronic low-dose aspirin users after treatment for Helicobacter pylori : a territory-wide cohort study , Gut. 2019, gutjnl-2019-318352.
GUO C., Chen L., Chan E.W.Y., Cheung K.S.M., Isshiki T., Wong I.C.K. and Leung W.K., Systematic review with meta- analysis: the risk of gastrointestinal bleeding in patients taking third-generation P2Y12 inhibitors compared with clopidogrel, Alimentary Pharmacology & Therapeutics. 2019.
LIU F., ZHANG S., Huang F.Y., Wong D.K.H., Mak L.Y., Cheung K.S.M., Lai C.L., Yuen R.M.F. and Seto W.K.W., Characterization of regulatory T cells and the role of PD-1 and TNF-alpha in spontaneous hepatitis B surface antigen seroclearance in chronic hepatitis B, JOURNAL OF HEPATOLOGY. ELSEVIER SCIENCE BV PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, 2019, 70: E454-E455.
LIU F., ZHANG S., Huang F.Y., Wong D.K.H., Mak L.Y., Cheung K.S.M., Lai C.L., Yuen R.M.F. and Seto W.K.W., Characterization of regulatory T cells and the role of PD-1 and TNF-alpha in spontaneous hepatitis B surface antigen seroclearance in chronic hepatitis B, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2019, 701: E454-455.
LIU F., Seto W.K.W., Wong D.K.H., Huang F.Y., Cheung K.S.M., Mak L.Y., Sharma R., ZHANG S., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Plasma fibronectin levels identified via quantitative proteomics profiling predicts hepatitis B surface antigen seroclearance in chronic hepatitis B, The Journal of Infectious Diseases. 2019, 220(6): 940-950.
Lam Y.F., Seto W.K.W., Tong S.M., Cheung K.S.M., Lo O.S.H., Hung F.N.I., Law W.L. and Leung W.K., Rates of metachronous adenoma after curative resection for left-sided or right-sided colon cancer, Intestinal Research. 2018, 16: 619-627.
Leung W.K., Chen L., Seto W.K.W. and Cheung K.S.M., Characteristics and risk factors of post-colonoscopy interval cancers: a population-based study from Asia, Digestive Disease Week. 2019.
Liu F., Seto W.K.W., Wong D.K.H., Huang F.Y., Mak L.Y., Cheung K.S.M., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Serum Fibronectin Levels Identified Via Proteomics Profiling Predict Spontaneous Hepatitis B Surface Antigen Seroclearance in Chronic Hepatitis B, HEPATOLOGY. WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2018, 68: 1185A-1186A.
Liu S.H.K., Seto W.K.W., Lau E.H.Y., Wong D.K.H., Lam Y.F., Cheung K.S.M., Mak L.Y., Ko K.L., To W.P., Law M.W.K., Wu J.T.K., Lai C.L. and Yuen R.M.F., A territory-wide prevalence study on blood-borne and enteric viral hepatitis in Hong Kong, The Journal of Infectious Diseases. 2019, 219(12): 1924-1933.
Ma H.C.J., Mak L.Y., Cheung K.S.M., Fung J.Y.Y., Lai C.L., Yuen R.M.F. and Seto W.K.W., Concomitant diabetes mellitus increases risk of liver fibrosis in treatment-naive chronic hepatitis B with low viral loads: Results from a matched case-control study, JOURNAL OF HEPATOLOGY. ELSEVIER SCIENCE BV PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, 2019, 70: E264-E264.
Mak L.Y., Lee C.H.P., Cheung K.S.M., Wong D.K.H., LIU F., Hui R.W., Fung J.Y.Y., Xu A., Lam K.S.L., Yuen R.M.F. and Seto W.K.W., Association of adipokines with hepatic steatosis and fibrosis in chronic hepatitis B patients on long‐term nucleoside analogue, Liver International. 2019, 39(7): 1217-1225.
Mak L.Y., Wong D.K.H., Seto W.K.W., Ning Q., Cheung K.S.M., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Correlation of serum Mac-2-binding protein glycosylation isomer (M2BPGi) and liver stiffness in chronic hepatitis B infection, Hepatology International. 2019, 13(2): 148-156.
Mak L.Y., Wong D.K.H., Seto W.K.W., Cheung K.S.M., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., High Serum Mac-2-binding protein glycosylation isomer (M2BPGi) level was associated with incident hepatocellular carcinoma in entecavir-treated chronic hepatitis B patients, Hepatology. 2018, 68: 864A-864A.
Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Mak L.Y., Wong D.K.H., Fung J.Y.Y., Liu S.H.K., Cheung K.S.M., Lai C.L., Kwong Y.L. and Yuen R.M.F., Monitoring and Treatment of Patients Undergoing Immunotherapy With Anti-CD20 Who are Exposed to HBV, Clinical Gastroenterology and Hepatology. 2018, 17(7): 1410-1412.
Seto W.K.W., Liu S.H.K., Mak L.Y., Cheung K.S.M., Wong D.K.H., Liu F., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Treatment Cessation in Chronic Hepatitis B: Predicting Off-Treatment Durability Via Combination of Viral Markers, HEPATOLOGY. WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2018, 68: 248A-249A.
Yuen R.M.F., Liu S.H.K., Seto W.K.W., Wong D.K.H., Wong S.Y., Cheung K.S.M., Mak L.Y.L., Ko K.L.M., To W.P.E., Yuen J.C.H., Wu C.H., Cheng C.T.K., Wu J.T.K. and Lau E.H.Y., Faculty Knowledge Exchange Award, HKU LKS Faculty of Medicine. 2019.


Researcher : Cheung RTF

Project Title:Role of ischemia in Alzheimer's disease - an experimental study in transgenic mice
Investigator(s):Cheung RTF
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2004


Project Title:Neuroprotective effects of melatonin and/or electro-acupuncture (EA) on focal cerebral ischemia in rats
Investigator(s):Cheung RTF
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2009


List of Research Outputs

Cheung R.T.F., Editorial Board, Asian Journal of Neuroscience. Hindawi Publishing, 2019.
Cheung R.T.F., Editorial Board, Austin Journal of Anatomy. Austin Publishing Group, 2018.
Cheung R.T.F., Editorial Board, Austin Journal of Cerebrovascular Disease & Stroke. Austin Publishing Group, 2019.
Cheung R.T.F., Editorial Board, Chinese Journal of Neurology. Chinese Medical Association, 2019.
Cheung R.T.F., Editorial Board, Edorium Journal of Neurology. Edorium Journal, 2019.
Cheung R.T.F., Editorial Board, JSM Ophthalmology. JSciMedCentral, 2019.
Cheung R.T.F., Editorial Board, Journal of Pineal Research. Blackwell Publishing, 2019.
Cheung R.T.F., Editorial Board, Reviews on Recent Clinical Trials. Bentham Science Publishers, 2019.
Cheung R.T.F., Editorial Board, Stroke Research and Treatment. Hindawi Publishing Corporation, 2019.
Cheung R.T.F., Editorial Board, The Open Nuclear Medicine Journal. Bentham Science Publishers, 2019.
Cheung R.T.F., Editorial Board, World Journal of Biological Chemistry. Baishideng Publishing Group, 2019.
Cheung R.T.F., Journal editor, SM Journal of Neurology and Neuroscience. SM Group, 2019.
Cheung R.T.F., Neurologic immune-related adverse events, Immuno-Oncology Hong Kong 2018 Preceptorship Programme, Medical OncologyTeam, HKU Department of Medicine, December 17-21, 2018. 2018.
Cheung R.T.F., Regional Editor, Cardiovascular & Hematological Agents in Medicinal Chemistry. Bentham Science Publishers, 2018.
Cheung R.T.F., Session Chairperson for Symposium VII: Atrial fibrillation and stroke, 14th International Symposium on Healthy Aging, 16-17 March 2019, Ballroom, 3/F Sheraton Hong Kong Hotel & Towers, Tsimshatsui, Hong Kong. 2019.


Researcher : Cheung TT

Project Title:Provision of Free Herpes Zoster Vaccine for Patients with Inflammatory Arthritis Requiring Biologic Therapies
Investigator(s):Cheung TT, Lau WCS
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:08/2017


List of Research Outputs

Chan S.L.Y., TSOI M.F., Cheung T.T. and Cheung B.M.Y., Stroke incidence in Hong Kong after recall of contaminated generic valsartan, 24th Medical Research Conference. Hong Kong, Hong Kong Medical Journal, 2019, 25 (1), supp 1: 9.
Chan Y.H., Ngai M.C., Chen Y., Wu M., YU Y., ZHEN Z., Lai K.W.H., Cheung T.T., Ho L.M., Chung H.Y., Lau W.C.S., Tse H.F. and Yiu K.H., Cumulative Rheumatic Inflammation Modulates the Bone–Vascular Axis and Risk of Coronary Calcification, Journal of the American Heart Association. 2019, 8.
Chan Y.H., Ngai M.C., Chen Y., Wu M., YU Y., ZHEN Z., Lai K.W.H., Cheung T.T., Ho L.M., Chung H.Y., Lau W.C.S., Lau C.P., Tse H.F. and Yiu K.H., Osteogenic circulating endothelial progenitor cells are linked to electrocardiographic conduction abnormalities in rheumatic patients, Annals of Noninvasive Electrocardiology. 2019, e12651.
Cheung C.L., Sing C.W., Wong W., Kiel D., Cheung E., Lam J., Cheung T.T., Chan E.W.Y., Kung A.W.C. and Wong I.C.K., Association of Alendronate and Risk of Cardiovascular Events in Patients with Hip Fracture., Annual Meeting of the American-Society-for-Bone-and-Mineral-Research.. 2018.
Cheung T.T., Chiu W.Y.J., Yuen R.M.F., Lam K.S.L., Cheung B.M.Y., Feng H.P., Yeh W.W., Wang J.D., Li W.T., Zhao X.M., Wang Z.Q. and Mu S.M., A Phase I, Single- and Multiple-dose Study to Evaluate the Pharmacokinetics of Elbasvir and Grazoprevir in Healthy Chinese Participants” [Clinical Therapeutics 40 (2018) 719–732], Clinical Therapeutics. 2018, 40: 719-732.
Cheung T.T., TSOI M.F., Cheung B.M.Y. and Lau W.C.S., Mortality and causes of death in inflammatory arthritis patients in Hong Kong 1997-2016, 24th Medical Research Conference. Hong Kong, Hong Kong Medical Journal, 2019, 25 (1), supp 1: 13.
Huang D., Cheng Y., Wong Y.T.A., Yung S.A., Tam C.C., Chan K.W.K., Lam C.C.S., Yiu K.H., Hai S.H.J.J., Lau C.P., Chan E.W.Y., Chiang C.E., Wong K.L., Cheung T.T., Cheung B.M.Y., Feng Y.Q., Tam N., Chen J.Y., Yue W.S., Hu H.X., Chen L., Tse H.F., Chan P.H.M. and Siu D.C.W., Thrombolysis in myocardial infarction risk score for secondary prevention of recurrent cardiovascular events in a real-world cohort of post-acute myocardial infarction patients, Circulation. 2019, 83(4): 809-817.
Lui K.W.K., TSOI M.F., Cheung T.T., Cheung C.L. and Cheung B.M.Y., Are blood lead levels in the United States still declining? The United States National Health Nutrition and Examination Survey 1999-2016, 24th Medical Research Conference. Hong Kong, Hong Kong Medical Journal, 2019, 25(1) suppl 1: 30.
Sing C.W., Wong Y.S., Kiel D.P., Cheung E.Y., Lam K.Y.J., Cheung T.T., Chan E.W., Kung A.W.C., Wong I.C.K. and Cheung C.L., Association of Alendronate and Risk of Cardiovascular Events in Patients With Hip Fracture, Journal of Bone and Mineral Research. 2018, 33: 1422-1434.
Sing C.W., Wong A.Y., Kiel D.P., Cheung E.Y., Lam J.K., Cheung T.T., Chan E.W., Kung A.W.C., Wong I.C.K. and Cheung C.L., Reply to: Association Between Alendronate and All-Cause Mortality and Cardiovascular Mortality Among Hip Fracture: An Alternative Explanation, J Bone Miner Res. 2018, 33(10): 1908-1909.
TSOI M.F., Cheung B.M.Y., Lau W.C.S. and Cheung T.T., Association between blood lead level and gout: the United States National Health Nutrition and Examination Survey 2007-2014, 24th Medical Research Conference. Hong Kong, Hong Kong Medical Journal, 2019, 25 (1), supp 1: 39.
TSOI M.F., LUI K.K.W., Cheung T.T. and Cheung B.M.Y., Association between blood lead level and hypertension: the United States National Health Nutrition and Examination Survey 1999-2006, 24th Medical Research Conference. Hong Kong, Hong Kong Medical Journal, 2019, 25 (1), supp 1: 40.
TSOI M.F., Cheung T.T. and Cheung B.M.Y., Hyperlipidaemic effect of Janus kinase inhibitors: a meta-analysis, 24th Medical Research Conference. Hong Kong, Hong Kong Medical Journal, 2019, 25 (1), supp 1: 40.
TSOI M.F., Cheung B.M.Y., Lau W.C.S. and Cheung T.T., Incidence, prevalence, and utilisation of urate-lowering therapy in Hong Kong: a population-based study, 24th Medical Research Conference. Hong Kong, Hong Kong Medical Journal, 2019, 25 (1), supp 1: 41.


Researcher : Cheung YY

Project Title:Impact of genetic variants identified in genome-wide association studies and their possible interaction with hypertension on the risk of diabetic retinopathy
Investigator(s):Cheung YY, Lam KSL, Sham PC, Wong DSH, Gangwani RA, Yuen MAM
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:05/2016
Completion Date:08/2019


Project Title:A pilot study of circulating microRNAs as potential biomarkers for the development of sight-threatening diabetic retinopathy in Chinese patients with type 2 diabetes
Investigator(s):Cheung YY
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:05/2018


Project Title:54th Annual Meeting of the European Association for the Study of Diabetes; Genetic regulation of pigment epithelium-derived factor (PEDF), a multifunctional anti-tumour factor: an Exome-chip association analysis in subjects with type 2 diabetes
Investigator(s):Cheung YY
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2018
Completion Date:10/2018


Project Title:Circulating microRNA-34a as novel biomarker for early detection of diabetic nephropathy in patients with type 2 diabetes
Investigator(s):Cheung YY, Lam KSL
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:03/2019


List of Research Outputs

Cheung Y.Y., Lee C.H.P., Tang S.M., Xu A., Au K.W., Fong H.Y., Ng K.K., KWOK H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Hai S.H.J.J., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Genetic regulation of Pigment Epithelium-Derived Factor (PEDF): an exome-chip association analysis in Chinese subjects with type 2 diabetes, Diabetes. 2019, 68: 198-206.
Lee C.H.P., Cheung Y.Y., Woo Y.C., Lui D.T.W., Yuen M.A.M., Fong H.Y., Chow W.S., Xu A. and Lam K.S.L., Circulating Adipocyte Fatty Acid–Binding Protein Concentrations Predict Multiple Mortality Outcomes among Men and Women with Diabetes, Clinical Chemistry. 2018, clinchem.2018.289157.
Lee C.H.P., Chan R.S.M., Wan Y., Woo Y.C., Cheung Y.Y., Fong H.Y., Cheung B.M.Y., Lam T.H., Janus E., Woo J. and Lam K.S.L., Dietary Intake of Anti-Oxidant Vitamins A, C, and E Is Inversely Associated with Adverse Cardiovascular Outcomes in Chinese—A 22-Years Population-Based Prospective Study, Nutrients. 2018, 10: 1664.
Lee C.H.P., Cheung Y.Y., Woo Y.C., Lui D.T.W., Yuen M.A.M., Fong H.Y., Chow W.S., Xu A. and Lam K.S.L., Prospective associations of circulating adipocyte fatty acid-binding protein levels with risks of renal outcomes and mortality in type 2 diabetes, Diabetologia. 2019, 62: 169-177.
Tang S.M., Cheung Y.Y., Lam K.S.L. and Sham P.C., Faculty of Medicine research output prize (2018-2019) - Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants, LKS Faculty of Medicine, HKU. 2019.
Wong Y.K., Cheung Y.Y., Tang S.M., Au K.W., Hai S.H.J.J., Lee C.H.P., Lau G.K.K., Cheung B.M.Y., Sham P.C., Xu A., Lam K.S.L. and Tse H.F., Age-Biomarkers-Clinical Risk Factors for Prediction of Cardiovascular Events in Patients With Coronary Artery Disease., Arterioscler Thromb Vasc Biol. American Heart Association, Inc., 2018, 38: 2519-2527.


Researcher : Chim JCS

Project Title:FISH study and the use of bortezomib in high-risk multiple myeloma
Investigator(s):Chim JCS
Department:Medicine
Source(s) of Funding:Lee Hysan Foundation - General Award
Start Date:07/2008


Project Title:Genetic study (FISH study) for personalized treatment of multiple myeloma
Investigator(s):Chim JCS
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:11/2012


Project Title:Use of Bortezomib during conditioning of autologous stem cell transplantation of international stage III myeloma
Investigator(s):Chim JCS, Kwong YL, Lie AKW
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:03/2014


Project Title:Mechanism study of the effect of microenviroment on RANKL expression in myeloma cells
Investigator(s):Chim JCS, Wong KY
Department:Medicine
Source(s) of Funding:National Natural Science Foundation of China (NSFC) - General Program
Start Date:01/2015


Project Title:Epigenetic silencing of tumor suppressor long non-coding RNA BM742401 in chronic lymphocytic leukemia
Investigator(s):Chim JCS
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:06/2016


Project Title:Identification of methylated miRNAs in acute promyelocytic leukaemia and their potential clinical application
Investigator(s):Chim JCS
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:08/2016


Project Title:Application of two cycles of Bortezomib as Consolidation after autologous stem cell transplantation in multiple myeloma
Investigator(s):Chim JCS, Tse EWC, Wong HYH
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:02/2017


Project Title:Minimal Residual Disease in Multiple Myeloma
Investigator(s):Chim JCS
Department:Medicine
Source(s) of Funding:Hong Kong Blood Cancer Foundation - General Award
Start Date:06/2017


Project Title:Clinical outcomes of patients with relapsed/refractory multiple myeloma - the real-life experience in Hong Kong
Investigator(s):Chim JCS
Department:Medicine
Source(s) of Funding:Takeda Pharmaceuticals (HK) Ltd
Start Date:03/2018


Project Title:The role of methylation-mediated silencing of HOTTIP in mantle cell lymphoma
Investigator(s):Chim JCS, Wong KY
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:07/2018


List of Research Outputs

BAI Y. and Chim J.C.S., Ficolled bone marrow is superior to bone marrow buffy coat for detection of minimal residual disease in multiple myeloma, Hematology. 2019, 24: 533-537.
Chim J.C.S., Wong V.K.C., Au Y.L.E. and Kwong Y.L., 3-weekly Daratumumab-IMiD-dexamethasone is highly efficacious, hence financially affordable with enormous economic impacy for relapsed/ refractory Multiple Myeloma in less affluent counties, The 24th Congress of European Haematology Association, Amsterdam, Netherlands. 2019.
Hungria V.T.M., Lee J.H., Maiolino A., de Queiroz Crusoe E., Martinez G., Bittencourt R., Duarte G.O., Fantl D.B., Navarro J.R., Conte G., Gomez-Almaguer D., Ruiz-Argüelles G.J., Kim K., Shimizu K., Chen W., Huang S.Y., Chng W.J., Chim J.C.S., Nawarawong W. and Durie B., Survival differences in multiple myeloma in Latin America and Asia: a comparison involving 3664 patients from regional registries, Annals of Hematology. 2019, 98: 941-949.
Jurczyszyn A., Davila J., Kortüm K.M., Jayabalan D.S., Vij R., Fiala M., Milunovic V., Chim J.C.S., Wiśniewska-Piąty K., Waszczuk-Gajda A., Crusoe E., Hajek R., Robak P., Raźny M., Zawirska D., Bittrich M., Nahi H., Liu J., Castillo J.J. and Vesole D.H., Multiple myeloma in patients up to 30 years of age: a multicenter retrospective study of 52 cases, Leukemia & Lymphoma. 2019, 60: 471-476.
Tan D., Lee J.H., Chen W., Shimizu K., Hou J., Suzuki K., Nawarawong W., Huang S.Y., Chim J.C.S., Kim K., Kumar L., Malhotra P., Chng W.J. and Durie B., Recent advances in the management of multiple myeloma: clinical impact based on resource-stratification. Consensus statement of the Asian Myeloma Network at the 16th international myeloma workshop, Leukemia & Lymphoma. 2018, 59: 2305-2317.
Wong K.Y., YAO Q., Yuan L., LI Z., Ma E.S.K. and Chim J.C.S., Frequent functional activation of RAS signalling not explained by RAS/RAF mutations in relapsed/refractory multiple myeloma, Scientific Reports. 2018, 8.
YAO Q., Morgan G.J. and Chim J.C.S., Distinct promoter methylation profile reveals spatial epigenetic heterogeneity in 2 myeloma patients with multifocal extramedullary relapses, Clinical Epigenetics. 2018, 10.
YAO Q., BAI Y., Orfao A. and Chim J.C.S., Standardized Minimal Residual Disease Detection by Next-Generation Sequencing in Multiple Myeloma, Frontiers in Oncology. 2019, 9.


Researcher : Chiu JWY

Project Title:A study of the combination of sirolimus-based immunosuppressant with sorafenib in recurrent hepatocellular carcinoma (HCC) post liver transplant (LT)
Investigator(s):Chiu WYJ, Yau TCC, Cheung TT
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research for New Staff
Start Date:06/2015


List of Research Outputs



Researcher : Chiu KCP

List of Research Outputs

Choy N.K.B., ZHU M., Pang J.C.S., Chan J.C.H., Ng L.K.A., Fan C.Y., Iu L.P.L., Kwan J.S.K., Lai J.S.M. and Chiu K.C.P., Factors Associated with Poor Eye Drop Administration Technique and the Role of Patient Education among Hong Kong Elderly Population, Journal of Ophthalmology. 2019, 2019: 1-5.
Ho R.T.H., Fong T.C.T., Hon T., Yau C.Y.J., Li B.Y., Chan W.C., Kwan J.S.K., Chiu K.C.P. and Lam L.C.W., Effects of a randomized controlled trial of Dance Movement Therapy on elderly with early dementia, Movement: Brain, Body, Cognition. Harvard, Boston, Harvard Medical School, 2018.
Ho R.T.H., Fong T.C.T., Chan W.C., Kwan J.S.K., Chiu K.C.P., Yau C.Y.J. and Lam L.C.W., Psychophysiological Effects of Dance Movement Therapy and Physical Exercise on Older Adults With Mild Dementia: A Randomized Controlled Trial, The Journals of Gerontology: Series B. 2018.


Researcher : Chiu WYJ

Project Title:A study of the combination of sirolimus-based immunosuppressant with sorafenib in recurrent hepatocellular carcinoma (HCC) post liver transplant (LT)
Investigator(s):Chiu WYJ, Yau TCC, Cheung TT
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research for New Staff
Start Date:06/2015


List of Research Outputs

Cheung T.T., Chiu W.Y.J., Yuen R.M.F., Lam K.S.L., Cheung B.M.Y., Feng H.P., Yeh W.W., Wang J.D., Li W.T., Zhao X.M., Wang Z.Q. and Mu S.M., A Phase I, Single- and Multiple-dose Study to Evaluate the Pharmacokinetics of Elbasvir and Grazoprevir in Healthy Chinese Participants” [Clinical Therapeutics 40 (2018) 719–732], Clinical Therapeutics. 2018, 40: 719-732.
Chiu W.Y.J., Best of SABCS 2018 lecture on novel treatment for HER2-positive breast cancer, Best of SABCS 2018 symposium, organised by Breast Oncology Group (12 Jan 2019). 2019.
Chiu W.Y.J., Leung R.C.Y., Tang Y.F.V., Cheuk W.Y.I., Lo L.F., Kwok G.W., Wong H.Y.H., Suen T.K.D., Cheung P., Wong T.T., Yau T.C.C. and Kwong A., Changing pattern of recurrences in patients with early HER2-positive breast cancer receiving neoadjuvant chemotherapy in the era of dual anti-HER2 therapy, Postgraduate Medical Journal. 2019, 95: 155-161.
Chiu W.Y.J., How to balance cardio toxicity with cancer risk, invited lecture, Third Hong Kong End Stage Heart Failure Management Symposium, 14th July 2018 , 2018.
Chiu W.Y.J., Immune-related adverse effect - case discussion, Io-IO AE management forum, sponsored by BMS, 10th Sep 2018, 2018.
Chiu W.Y.J., Immunooncology preceptorship lectures, Immunooncology Preceptorship Program, sponsored by BMS, 26- 30/11/2018. 2018.
Chiu W.Y.J., Neoadjuvant therapy for breast cancer: local expert opinion and recent evidence, Hong Kong International Oncology Forum, 8th Sep 2018, 2018.
Chiu W.Y.J., Optimal treatment sequence in HR+ advanced breast cancer - what have we learnt to overcome resistance. Invited lecture by HKBCF, Hong Kong-Taiwan HR+ Advanced Breast Cancer Scientific Meeting, 3rd Aug 2018, 2018.
Chiu W.Y.J., Optimising pharmacological management for metastatic breast cancer patients harbouring BRCA mutation, Breast Cancer Summit, Hong Kong Breast Oncology Group, 1st Sep 2018, 2018.
Chiu W.Y.J., Phase 1 oncology in Hong Kong, NECTA annual meeting 2019, Sydney, Austria, 28th March 2019. 2019.
Chiu W.Y.J., Treatment of HER2-positive breast cancer, mBC Lecture Tour, Taiwan (23-25 May 2019). 2019.
Chiu W.Y.J., Treatment of breast cancer and implication of neoadjuvant therapy, Master course in Clinical Pharmacy, Hong Kong (8 April 2019). 2019.
Gutierrez M., Hellmann M.D., Gubens M.D., Aggarwal C.A., Tan D.S.W., Filip E., Chiu W.Y.J., Lee J.S., Yang J.C.H. and Garon E.B., KEYNOTE-495/KeyImPaCT: Phase 2 biomarker-directed precision oncology study of pembrolizumab-based combination therapy for non–small cell lung cancer, AACR 2019, Atlanta, USA (28 March - 3 Apr 2019). 2019.
Iwata H., Masuda N., Kim S.-.B., Inoue K.S.L., Rai Y.-.S., Fujita T., Chiu W.Y.J., Ohtani S., Takahashi M., Miyaki T.-.Y., Lu Y.-.S., Xu B., Yap Y.-.S., Bustam A., Yao B., Zhang B., Bryce R. and Chan A., Neratinib after trastuzumab-based adjuvant therapy in patients from Asia with early stage HER2-positive breast cancer, Future Oncology. 2019.
Kim S.-.B., Do I.-.G., Tsang J., Kim T.-.Y., Yap Y.-.S., Cornelia G., Gong G., Paik S., Lee S., Ng T.-.Y., Park S., Oh H.-.S., Chiu W.Y.J., Sohn J., Lee M., Choi Y.-.J., Lee E.M., Park K.-.H., Nathaniel C. and Ro J., BioPATH: A Biomarker Study in Asian Patients with HER2+ Advanced Breast Cancer Treated with Lapatinib and Other Anti-HER2 Therapy, Cancer Research and Treatment. 2019.


Researcher : Chong WC

List of Research Outputs

Kwok H.H., NING Z., Chong W.C., Wan T.S.K., Ng M.H.L., Ho G.Y.F., Ip M.S.M. and Lam C.L.D., Transfer of Extracellular Vesicle-Associated-RNAs Induces Drug Resistance in ALK-Translocated Lung Adenocarcinoma, In: Prof. Samuel C. Mok, Cancers. Basel, Switzerland, MDPI, 2019, 11: 104.
Lui M.S.M., Tse H.F., Mak J.C.W., Lam C.L.D., Chan W.S., Chong W.C. and Ip M.S.M., Untreated Obstructive Sleep Apnea Is Associated With Myocardial Injury Independent of Blood Pressure Control in Hypertension, Journal of Clinical Sleep Medicine. 2018, 14: 1841-1847.


Researcher : Chow WS

List of Research Outputs

Cheung Y.Y., Lee C.H.P., Tang S.M., Xu A., Au K.W., Fong H.Y., Ng K.K., KWOK H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Hai S.H.J.J., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Genetic regulation of Pigment Epithelium-Derived Factor (PEDF): an exome-chip association analysis in Chinese subjects with type 2 diabetes, Diabetes. 2019, 68: 198-206.
Lee C.H.P., Cheung Y.Y., Woo Y.C., Lui D.T.W., Yuen M.A.M., Fong H.Y., Chow W.S., Xu A. and Lam K.S.L., Circulating Adipocyte Fatty Acid–Binding Protein Concentrations Predict Multiple Mortality Outcomes among Men and Women with Diabetes, Clinical Chemistry. 2018, clinchem.2018.289157.
Lee C.H.P., Cheung Y.Y., Woo Y.C., Lui D.T.W., Yuen M.A.M., Fong H.Y., Chow W.S., Xu A. and Lam K.S.L., Prospective associations of circulating adipocyte fatty acid-binding protein levels with risks of renal outcomes and mortality in type 2 diabetes, Diabetologia. 2019, 62: 169-177.
Lui D.T.W., Woo Y.C., Chow W.S., Lee C.H.P., Lee C.H.A., Leung E.K.H., Tan K.C.B., Lam K.S.L. and Lam K.Y.J., Glycogenic hepatopathy as an unusual etiology of deranged liver function in a patient with type 1 diabetes, Medicine. 2019, 98: e15296.


Researcher : Chu LW

Project Title:A dementia outreach programme in Central, Western and Southern districts of Hong Kong
Investigator(s):Chu LW, Lam KSL, Lee WHP
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:09/2003


List of Research Outputs

Shea Y.F., Lee M.C., Mok M.Y., Lam M.F., Chu L.W., Chan H.W.F. and Chan D.T.M., Self-Care Peritoneal Dialysis Patients with Cognitive Impairment Have a Higher Risk of Peritonitis in the Second Year, Peritoneal Dialysis International. 2019, 39(1): 51-58.
Wang B., Bao S., ZHANG Z., ZHOU X., WANG J., Fan Y., Zhang Y., Li Y., Chen L.P., Jia Y., LI J., Li M., Zheng W., Mu N., Yang W., Yu Z., Lau D.S.S., Wong S.M., ZHANG Y., Kwan J.S.K., Mak H.K.F., Ambalavanan A., Zhou S., Cai W., Zheng J., Huang S., Rouleau G.A., Yang W., Rogaeva E., Ma X., St George-Hyslop P., Chu L.W. and Song Y., A rare variant in MLKL confers susceptibility to ApoE ɛ4-negative Alzheimer's disease in Hong Kong Chinese population, Neurobiol Aging. 2018, 68:160: e1-e7.
ZHANG Z., Bao S., WANG B.B., MA X. and Chu L.W., MLKL Loss-of-Function Variant Increases Alzheimer’s Disease Risk Through Modulating γ-Secretase Activity, 2019 Hong Kong Inter-University Postgraduate Symposium in Biochemical Sciences. 2019.
ZHANG Z., Bao S., Wang B., Ma X., Chu L.W. and Song Y., MLKL Loss-of-Function Variant Increases Alzheimer’s Disease Risk Through modulating γ-Secretase Activity, SBMS Research Day, School of Biomedical Sciences, The University of Hong Kong. 2018.


Researcher : Chung ACK

Project Title:Signaling mechanisms of angiotensin II-induced epithelial-mesenchymal transition in renal tubular epithelial cells
Investigator(s):Chung ACK, Lan HY
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:03/2008




Researcher : Chung HY

Project Title:Quantitative assessment of the Spondyloarthitis (SpA) severity by using Diffusion Weighted Imaging (DWI) in 3T magnetic resonance imaging
Investigator(s):Chung HY
Department:Medicine
Source(s) of Funding:Novartis Pharmaceuticals (HK) Ltd
Start Date:12/2017


Project Title:To assess the relationship between serum Dickkopf-1 and sclerostin levels with disease activity in patients with axial spondyloarthritis
Investigator(s):Chung HY, Tsang HLH, Lau WCS
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research for New Staff
Start Date:03/2018


Project Title:Assessment of relationship between spondyloarthritis(SpA) severity by Diffusion Weighted Imaging (DWI) in 3T magnetic resonance imaging and uveitis activity in anterior uveitis patients
Investigator(s):Chung HY
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:03/2019


List of Research Outputs

Chan L.Y. and Chung H.Y., Sulfasalazine-Induced Connective Tissue Disease, JCR: Journal of Clinical Rheumatology. 2019, 1.
Chan Y.H., Ngai M.C., Chen Y., Wu M., YU Y., ZHEN Z., Lai K.W.H., Cheung T.T., Ho L.M., Chung H.Y., Lau W.C.S., Tse H.F. and Yiu K.H., Cumulative Rheumatic Inflammation Modulates the Bone–Vascular Axis and Risk of Coronary Calcification, Journal of the American Heart Association. 2019, 8.
Chan Y.H., Ngai M.C., Chen Y., Wu M., YU Y., ZHEN Z., Lai K.W.H., Cheung T.T., Ho L.M., Chung H.Y., Lau W.C.S., Lau C.P., Tse H.F. and Yiu K.H., Osteogenic circulating endothelial progenitor cells are linked to electrocardiographic conduction abnormalities in rheumatic patients, Annals of Noninvasive Electrocardiology. 2019, e12651.
Chung H.Y., APLAR-Celltrion Best Abstract Award for APLAR 2018, Asia Pacific League of Associations for Rheumatology. 2018.
Chung H.Y., Anterior thoracic fatty corner lesions in T1 Magnetic Resonance Imaging are useful for axial Spondyloarthritis diagnosis, 20th Asia Pacific League of Associations for Rheumatology Congress (APLAR 2018). 2018.
Chung H.Y., Anterior thoracic fatty lesions in T1 Magnetic Resonance Imaging are useful for axial Spondyloarthritis diagnosis. (20th Asia Pacific League of Associations for Rheumatology Congress [APLAR 2018]), 2018.
Chung H.Y. and Lau W.C.S., Apparent Diffusion Coefficient as an Imaging Biomarker for Spinal Disease Activity in Axial Spondyloarthritis, Radiology. 2019, 180960.
Chung H.Y., Associated editor, Journal of Clinical Rheumatology and Immunology. 2019.
Chung H.Y., Lau W.C.S., Tsang H.L.H., Wong O.M., Chan S.C.W., Li P.H. and Lee K.H., Clinical Associations of Uveitis in Axial Spondyloarthritis Group and Ankylosing Spondylitis Group: Do They Represent the Same Disease?, Journal of Clinical Rheumatology. 2018.
Chung H.Y., Clinical predictors of disease relapse and mortality in immunoglobulin G4-related disease from a retrospective cohort in Hong Kong, International Conference of Chinese Rheumatologist 2018. Best free paper award. 2018.
Chung H.Y., Lau W.C.S., Tsang H.L.H., Chan C.W.S., Li P.H., Lee K.H. and Wong P.Y.S., Diffusion-weighted imaging versus short tau inversion recovery sequence: Usefulness in detection of active sacroiliitis and early diagnosis of axial spondyloarthritis, PLoS one. 2018.
Chung H.Y., Disease activity assessment in axial spondyloarthritis, 2019 international symposium for Spondyloarthritis. 2019.
Chung H.Y., Disease monitoring in axial spondyloarthritis, The CUHK 2019 AIM conference. 2019.
Chung H.Y., The 30th Anniversary of the Hong Kong Society of Rheumatology, Voice of APLAR. APLAR, 2018, Vol 2 Issue 4.
Chung H.Y., Ustekinumab increases risk of herpes zoster in patients with spondyloarthritis, 20th Asia Pacific League of Associations for Rheumatology Congress (APLAR 2018), (2018 / 2018) . 2018.
Li P.H., Chung H.Y., Wong C.S., Tsang H.H.L., Lau V.W.H., Ho G., XU X., Lau W.C.S. and Ma K.Y., The Association Between Age and Clinical and Radiological Activity in Axial Spondyloarthritis, Journal of Clinical Rheumatology and Immunology. 2019, 1-8.
Tsang H.L.H., Cheung J.P.Y., Wong C.K.H., Cheung W.H.P., Lau W.C.S. and Chung H.Y., Psychometric validation of the EuroQoL 5-dimension (EQ-5D) questionnaire in patients with spondyloarthritis, Arthritis Research & Therapy. 2019, 21: 41.
Wong S.C.T. and Chung H.Y., Secukinumab-Induced Delayed-Type Drug Hypersensitivity Reactions, JCR: Journal of Clinical Rheumatology. 2019, 1.


Researcher : Deng J

List of Research Outputs

Kwok H.H., Lee C.M.N., Deng J., Ip M.S.M. and Lam C.L.D., Lung cancer patient–derived organoid biobank for therapeutic screening, 24th Medical Research Conference, Department of Medicine, HKU, Feb 2019. Hong Kong Medical Journal. 2019, 25 (Suppl.1): 24.


Researcher : FEI Y

List of Research Outputs

FEI Y., TSOI M.F. and Cheung B.M.Y., Cardiovascular outcomes in trials of new antidiabetic drug classes: a network meta-analysis, 24th Medical Research Conference. Hong Kong, Hong Kong Medical Journal, 2019, 25 (1), supp 1: 17.
FEI Y., TSOI M.F. and Cheung B.M.Y., Determining the Optimal Systolic Blood Pressure for Hypertensive Patients: A Network Meta-analysis, Canadian Journal of Cardiology. 2018, 34: 1581-1589.
FEI Y., LAM C.K. and Cheung B.M.Y., Efficacy and safety of newer P2Y12 inhibitors versus clopidogrel in patients with acute coronary syndrome, 24th Medical Research Conference. Hong Kong, Hong Kong Medical Journal, 2019, 25 (1), supp 1: 17.
FEI Y., TSOI M.F. and Cheung B.M.Y., Optimal duration of dual antiplatelet therapy after drug-eluting stent implantation: a network meta-analysis, 24th Medical Research Conference. Hong Kong, Hong Kong Medical Journal, 2019, 25 (1), supp 1: 18.


Researcher : FENG H

List of Research Outputs

JIANG D., XIONG G., FENG H., ZHANG Z., Chen P., Yan B., CHEN L., Kesavamoorthy G., MA C.Y., Li C., HAN S., Zhang Y., Liao C., Lee T.L., Tse H.F., Fu Q.L., Chiu K. and Lian Q., Donation of mitochondria by iPSC-derived mesenchymal stem cells protects retinal ganglion cells against mitochondrial complex I defect-induced degeneration, Theranostics. Australia, Ivyspring International Publisher, 2019, 2019, Vol. 9, Issue 8: 2395-2410.


Researcher : FU SN

List of Research Outputs

Dao M.C., FU S.N., Chan C.W., Wong C.K.H., Wong Y.S., Luk W. and Yiu Y.K., RACGP Foundation Best Poster Award, GP18 Conference, Royal Australian College of General Practitioners. 2018.
Dao M.C., FU S.N., Chan C.W., Wong C.K.H., Wong Y.S., Luk W. and Yiu Y.K., Use of Short Message Services (SMS) Reminders to Improve the Attendance Rate of Diabetes-related Multidisciplinary Services in a General Outpatient Clinic: A Randomized Controlled Trial in Hong Kong, GP18 - The Royal Australian College of General Practitioners (RACGP) annual conference. 2018.
FU S.N., Dao M.C., Wong C.K.H. and Yu W.C., SF-6D utility scores of smokers and ex-smokers with or without respiratory symptoms attending primary care clinics, Health and Quality of Life Outcomes. 2019, 17: 48.


Researcher : Feng T

List of Research Outputs

Pan Y., Hui X., Hoo R.L.C., Ye D., Chan C.Y.C., Feng T., Wang Y., Lam K.S.L. and Xu A., Adipocyte-secreted Exosomal Microrna-34a Inhibits M2 Macrophage Polarization To Promote Obesity-induced Adipose Inflammation, Journal of Clinical Investigation. 2019, 129: 834-849.


Researcher : Feng Z

Project Title:30th Annual Meeting of the Society for Neuroscience Identifying and Cloning of B218 Gene, which was Down Regulated by Kainic Acid Treatment and in the Developmental Stages
Investigator(s):Feng Z
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:11/2000




Researcher : Fong HY

List of Research Outputs

Cheung Y.Y., Lee C.H.P., Tang S.M., Xu A., Au K.W., Fong H.Y., Ng K.K., KWOK H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Hai S.H.J.J., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Genetic regulation of Pigment Epithelium-Derived Factor (PEDF): an exome-chip association analysis in Chinese subjects with type 2 diabetes, Diabetes. 2019, 68: 198-206.
Lee C.H.P., Cheung Y.Y., Woo Y.C., Lui D.T.W., Yuen M.A.M., Fong H.Y., Chow W.S., Xu A. and Lam K.S.L., Circulating Adipocyte Fatty Acid–Binding Protein Concentrations Predict Multiple Mortality Outcomes among Men and Women with Diabetes, Clinical Chemistry. 2018, clinchem.2018.289157.
Lee C.H.P., Chan R.S.M., Wan Y., Woo Y.C., Cheung Y.Y., Fong H.Y., Cheung B.M.Y., Lam T.H., Janus E., Woo J. and Lam K.S.L., Dietary Intake of Anti-Oxidant Vitamins A, C, and E Is Inversely Associated with Adverse Cardiovascular Outcomes in Chinese—A 22-Years Population-Based Prospective Study, Nutrients. 2018, 10: 1664.
Lee C.H.P., Cheung Y.Y., Woo Y.C., Lui D.T.W., Yuen M.A.M., Fong H.Y., Chow W.S., Xu A. and Lam K.S.L., Prospective associations of circulating adipocyte fatty acid-binding protein levels with risks of renal outcomes and mortality in type 2 diabetes, Diabetologia. 2019, 62: 169-177.
Shih K.C., Poon S., Yu S., Li R., Seng C., Lam I., Hui J., Fong H.Y., Fung N.S.K. and Lee C.H.P., Efficacy of an endocrinologist-led specialist care clinic in minimizing burden of vision-threatening retinopathy in Chinese diabetic patients, 2019 Annual Meeting of the Association for Research in Vision and Ophthalmology. 2019.


Researcher : Fung JYY

List of Research Outputs

Au K.P., Chok K.S.H., Sin S.L., Fung J.Y.Y., Lo C.M. and Mok V.W.K., Partial portal vein arterialization using right gastroepiploic artery: A novel solution for portal hypoperfusion (Letter to the Editor), Hepatobiliary & Pancreatic Diseases International. 2018, Epub ahead of print.
Chan M.Y.M., Chok K.S.H., Fung J.Y.Y., Ng S.L., Yiu M.K. and Lo C.M., Prospective study on sexual dysfunction in male Chinese liver transplant recipients, American Journal of Men's Health. 2019, 13(2): 155798831983513.
Chok K.S.H., Fung J.Y.Y., Dai W.C., Sin S.L., Ma K.W., Chan A.C.Y., Cheung T.T. and Lo C.M., Donor ductal anomaly is not a contraindication to right liver lobe donation, Hepatobiliary & Pancreatic Diseases International. 2019, Epub ahead of print.
Chu K.W.K., Chok K.S.H., Fung J.Y.Y., Chan A.C.Y., Dai W.C. and Lo C.M., Emergency ABO-incompatible living donor liver transplant for patients with ultrahigh MELD scores (Letter to the Editor), Hepatobiliary & Pancreatic Diseases International. 2019, 18: 87-89.
Fung J.Y.Y., Hepatorenal Syndrome - New Understanding and Management, GUT 2018 - Malaysian Society of Gastroenterology & Hepatology. 2018.
Fung J.Y.Y., Chok K.S.H., Chan A.C.Y., Dai W.C., She W.H., Sin S.L., Ma K.W., Ng K.C.K., Wong C.L.T., Cheung T.T., Seto W.K.W., Lai C.L., Lo C.M. and Yuen R.M.F., High Predictive value of MELD for short-term mortality in severe acute flares of chronic hepatitis B, Hepatology. 2018, 68: 1211A-1211A.
Fung J.Y.Y., Wong D.K.H., Tanaka Y., Lo C.L.R., Wong C.L.T., Chok K.S.H., Chan A.C.Y., Cheung T.T., Dai W.C., Ng K.C.K., Ng K.T.P., Man K., Ng I.O.L., Seto W.K.W., Lai C.L., Yuen R.M.F. and Lo C.M., Quantitative hepatitis B surface antigen in predicting recurrence of hepatitis B-related hepatocellular carcinoma after liver transplantation, Hepatoma Research. 2018, 4: 62.
Fung J.Y.Y., Chok K.S.H., Wong C.L.T., Dai W.C., Chan A.C.Y., Sin S.L., She W.H., Ma K.W., Ng K.C.K., Seto W.K.W., Yuen R.M.F. and Lo C.M., Risk Factors for Graft Steatosis after Liver Transplantation using Controlled Attenuation Parameter Measurements, Transplantation. 2018, 102: S863.
Fung J.Y.Y., Who Do I Refer for Liver Transplantation in 2018, GUT 2018 - Malaysian Society of Gastroenterology & Hepatology. 2018.
Hui Y.T., Wong G.L.H., Fung J.Y.Y., Chan H.L.Y., Leung N.W.Y., Liu S.D., Liu K., Ma Y.K., But Y.K.D., Mak W.Y., Chan J.M.C., Lai K.B., Loo C.K., Ng A.C.Y., Lai M.S., Chan C.W., Lau J.Y.L., Fan T.T.T., Hui A.J., Lam B.C.Y., Cheung W.I., Tsang O.T.Y., Lam K., Lai L.S.W., Luk W.F., Lao M.K.K., Lao W.C., Lam J.T.W., Tsang S.W.C., Kung K.N., Chow W.H., Tong R.K.N., Lui K.L., Shan E.H.S., Yuen R.M.F. and Wong V.W.S., Territory-wide population-based study of chronic hepatitis C infection and implications for hepatitis elimination in Hong Kong, Liver International. 2018, 38(11): 1911-1919.
Hung F.N.I., Wong D.K.H., Seto W.K.W., Fung J.Y.Y., Yuen K.Y. and Yuen R.M.F., A Double-Blind Randomized Controlled Trial of Intradermal Hepatitis B Vaccination with Topical Imiquimod in Subjects with Occult Hepatitis B Infection, HEPATOLOGY. WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2018, 68: 255A-256A.
Ko K.L., To W.P., Mak L.Y., Seto W.K.W., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., A Large Cohort Study Examining the Effects of Long-Term Entecavir on Hepatocellular Carcinoma and HBsAg Seroclearance, HEPATOLOGY. WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2018, 68: 260A-260A.
LIU F., Seto W.K.W., Wong D.K.H., Huang F.Y., Cheung K.S.M., Mak L.Y., Sharma R., ZHANG S., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Plasma fibronectin levels identified via quantitative proteomics profiling predicts hepatitis B surface antigen seroclearance in chronic hepatitis B, The Journal of Infectious Diseases. 2019, 220(6): 940-950.
Liu F., Seto W.K.W., Wong D.K.H., Huang F.Y., Mak L.Y., Cheung K.S.M., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Serum Fibronectin Levels Identified Via Proteomics Profiling Predict Spontaneous Hepatitis B Surface Antigen Seroclearance in Chronic Hepatitis B, HEPATOLOGY. WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2018, 68: 1185A-1186A.
Ma H.C.J., Mak L.Y., Cheung K.S.M., Fung J.Y.Y., Lai C.L., Yuen R.M.F. and Seto W.K.W., Concomitant diabetes mellitus increases risk of liver fibrosis in treatment-naive chronic hepatitis B with low viral loads: Results from a matched case-control study, JOURNAL OF HEPATOLOGY. ELSEVIER SCIENCE BV PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, 2019, 70: E264-E264.
Ma K.W., Chok K.S.H., Fung J.Y.Y. and Lo C.M., Liver transplantation for hepatitis B virus-related hepatocellular carcinoma in Hong Kong, Journal of Clinical and Translational Hepatology. 2018, 6(3): 283-288.
Ma K.W., She W.H., Chan A.C.Y., Cheung T.T., Fung J.Y.Y., Dai W.C., Lo C.M. and Chok K.S.H., Validated model for prediction of recurrent hepatocellular carcinoma after liver transplantation in Asian population, World Journal of Gastrointestinal Oncology. 2019, 11: 322-334.
Ma K.W., She W.H., Cheung T.T., Chan A.C.Y., Dai W.C., Fung J.Y.Y., Lo C.M. and Chok K.S.H., Validated nomogram for the prediction of disease-free survival after hepatectomy for hepatocellular carcinoma within the Milan criteria: individualizing a surveillance strategy, Surgery Today. 2019, 49: 521-528.
Mak L.Y., Lee C.H.P., Cheung K.S.M., Wong D.K.H., LIU F., Hui R.W., Fung J.Y.Y., Xu A., Lam K.S.L., Yuen R.M.F. and Seto W.K.W., Association of adipokines with hepatic steatosis and fibrosis in chronic hepatitis B patients on long‐term nucleoside analogue, Liver International. 2019, 39(7): 1217-1225.
Mak L.Y., Wong D.K.H., Seto W.K.W., Ning Q., Cheung K.S.M., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Correlation of serum Mac-2-binding protein glycosylation isomer (M2BPGi) and liver stiffness in chronic hepatitis B infection, Hepatology International. 2019, 13(2): 148-156.
Mak L.Y., Seto W.K.W., Hui R.W., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Fibrosis evolution in chronic hepatitis B E‐antigen negative patients across a 10‐year interval, Journal of Viral Hepatitis. 2019, 26(7): 818-827.
Mak L.Y., Wong D.K.H., Seto W.K.W., Cheung K.S.M., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., High Serum Mac-2-binding protein glycosylation isomer (M2BPGi) level was associated with incident hepatocellular carcinoma in entecavir-treated chronic hepatitis B patients, Hepatology. 2018, 68: 864A-864A.
Mak L.Y., Seto W.K.W., Fung J.Y.Y. and Yuen R.M.F., New Biomarkers of Chronic Hepatitis B, Gut and Liver. 2019.
Mak L.Y., Seto W.K.W., Fung J.Y.Y. and Yuen R.M.F., Novel developments of hepatitis B: treatment goals, agents and monitoring tools, Expert Review of Clinical Pharmacology. 2019, 12(2): 109-120.
Mak L.Y., To W.P., Wong D.K.H., Fung J.Y.Y., LIU F., Seto W.K.W., Lai C.L. and Yuen R.M.F., Serum Mac-2 binding protein glycosylation isomer level predicts hepatocellular carcinoma development in E-negative chronic hepatitis B patients, World Journal of Gastroenterology. 2019, 25: 1398-1408.
Mak L.Y., Ko M., To E., Wong D.K.H., Ma J.H.C., Hui T.L.Y., Seto W.K.W., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Serum Mac-2-binding protein glycosylation isomer and risk of hepatocellular carcinoma in entecavir-treated chronic hepatitis B patients, Journal of Gastroenterology and Hepatology. 2019.
Ng K.C.K., Cheung T.T., Wong C.L.T., Fung J.Y.Y., Dai W.C., Ma K.W., She W.H. and Lo C.M., Long-term survival comparison between primary transplant and upfront curative treatment with salvage transplant for early stage hepatocellular carcinoma, Asian Journal of Surgery. 2019, 42(2): 433-442.
Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Mak L.Y., Wong D.K.H., Fung J.Y.Y., Liu S.H.K., Cheung K.S.M., Lai C.L., Kwong Y.L. and Yuen R.M.F., Monitoring and Treatment of Patients Undergoing Immunotherapy With Anti-CD20 Who are Exposed to HBV, Clinical Gastroenterology and Hepatology. 2018, 17(7): 1410-1412.
Seto W.K.W., Liu S.H.K., Mak L.Y., Cheung K.S.M., Wong D.K.H., Liu F., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Treatment Cessation in Chronic Hepatitis B: Predicting Off-Treatment Durability Via Combination of Viral Markers, HEPATOLOGY. WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2018, 68: 248A-249A.
She W.H., Chok K.S.H., Li W.S., Ma K.W., Sin S.L., Dai W.C., Fung J.Y.Y. and Lo C.M., Pneumocystis jirovecii-related spontaneous pneumothorax, pneumomediastinum and subcutaneous emphysema in a liver transplant recipient: a case report, BMC Infectious Diseases. 2019, 19: 66.
Wong C.L.T., Ng K.C.K., Fung J.Y.Y., Chok K.S.H., Cheung T.T., Chan A.C.Y., Dai W.C. and Lo C.M., Comparable outcomes after right lobe vs. left lobe living donor liver transplantation, International Symposium for Commemoration of 5000 LDLTs at Asan Medical Center, Seoul, South Korea, 30 November - 1 December 2018.
Wong C.L.T., Ng K.C.K., Chok K.S.H., Cheung T.T., Chan A.C.Y., Fung J.Y.Y., Dai W.C. and Lo C.M., Excellent perioperative and long-term outcomes with lower graft-to-recipient weight ratio for living donor liver transplantation, The 27th International Congress of the Transplantation Society, Madrid, Spain, 30 June - 5 July 2018.
Wong C.L.T., Fung J.Y.Y., Chok K.S.H., Cheung T.T., Chan A.C.Y., Dai W.C., Ng K.C.K., Chan S.C. and Lo C.M., Hepatitis B vaccination in patients receiving oral antiviral therapy without hepatitis B immunoglobulin after liver transplant, Transplantation Proceedings. 2018, 50: 3681-3688.
Wong C.L.T., Fung J.Y.Y., Cui T.Y.S., Lam A.H.K., Dai W.C., Chan A.C.Y., Cheung T.T., Chok K.S.H., Ng K.C.K. and Lo C.M., Liver transplantation using hepatitis B core positive grafts with antiviral monotherapy prophylaxis, Journal of Hepatology. 2019, 70: 1114-1122.
Wong C.L.T., Ng K.C.K., Fung J.Y.Y., Chan A.C.Y., Cheung T.T., Chok K.S.H., Dai W.C. and Lo C.M., Long-term survival outcome between living donor and deceased donor liver transplant for hepatocellular carcinoma: intention-to-treat and propensity score matching analyses, Annals of Surgical Oncology. 2019, 26: 1454-1462.
Wong C.L.T., Lee V.H.F., Law A.H., Cui T.Y., Fung J.Y.Y., Sin S.L., Chan A.C.Y., Dai W.C., Chok K.S.H., Cheung T.T., Ng K.C.K., Leung T.W. and Lo C.M., Prospective study of stereotactic body radiation therapy as a bridging therapy for hepatocellular carcinoma patients on waiting list for liver transplantation., International Liver Transplant Society 25th Annual Congress, Toronto, Canada, 15-18 May 2019 . 2019.
Wong C.L.T., Shing B.S.Y., Cui T.Y.S., Tong C.H., Ng K.K.C., Fung J.Y.Y., Chan A.C.Y., Chok K.S.H., Cheung T.T., Dai W.C. and Lo C.M., What can we learn from living donor evaluation? A higher prevalence of metabolic diseases and less technical contraindication, Clinical Congress of American College of Surgeon 2018, San Francisco, U.S.A., 27-30 October 2018.
Wong C.L.T., Ng K.C.K., Fung J.Y.Y., Chok K.S.H., Cheung T.T., Chan A.C.Y., Dai W.C. and Lo C.M., Zero mortality using extreme small-for-size grafts with graft-to-recipient weight ratio <0.6% in living donor liver transplantation, The 13th World Congress of the International Hepato-Pancreato-Biliary Association, Geneva, Switzerland, 4-7 September 2018.
Wong D.K.H., Cheng C.Y.S., Mak L.Y., To W.P., Lo C.L.R., Cheung T.T., Seto W.K.W., Fung J.Y.Y., Man K., Lai C.L. and Yuen R.M.F., Among Patients with Undetectable Hepatitis B Surface Antigen and Hepatocellular Carcinoma, a High Proportion Has Integration of HBV DNA into Hepatocyte DNA and No Cirrhosis, Clinical Gastroenterology and Hepatology. 2019.
Wong D.K.H., Cheng C.Y.S., Mak L.Y., To W.P., Cheung T.T., Seto W.K.W., Fung J.Y.Y., Man K., Lai C.L. and Yuen R.M.F., High Rate of HBV DNA Integration in Hepatocellular Carcinoma Patients with Occult Hepatitis B Infection, HEPATOLOGY. WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2018, 68: 331A-331A.
Wong D.K.H., Cheng C.Y.S., Mak L.Y., To W.P., Cheung T.T., Seto W.K.W., Fung J.Y.Y., Man K., Lai C.L. and Yuen R.M.F., Integration of HBV DNA near cancer-related genes in HBsAg-negative hepatocellular carcinoma patients, JOURNAL OF HEPATOLOGY. ELSEVIER SCIENCE BV PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, 2019, 70: E269-E269.
Wong D.K.H., Cheng C.Y.S., Mak L.Y., To W.P., Cheung T.T., Seto W.K.W., Fung J.Y.Y., Man K., Lai C.L. and Yuen R.M.F., Integration of HBV DNA near cancer-related genes in HBsAg-negative hepatocellular carcinoma patients, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2019, 701: E269.
Yeo Y.H., Ho H.J., Yang H.-.I., Tseng T.-.C., Hosaka T., Trinh H.N., Kwak M.S., Park Y.M., Fung J.Y.Y., But M., Rodríguez M., Treeprasertsuk S., Preda C.M., Ungtrakul T., Charatcharoenwitthaya P., Li X., Li J., Zhang J., Le M.H., Wei B., Zou B., Le A., Jeong D., Chien N., Kam L., Lee C.-.C., Riveiro-Barciela M., Istratescu D., Sriprayoon T., Chong Y., Tanwandee T., Kobayashi M., Suzuki F., Yuen R.M.F., Lee H.-.S., Kao J.-.H., Lok A.S., Wu C.-.Y. and Nguyen M.H., Factors Associated With Rates of HBsAg Seroclearance in Adults With Chronic HBV Infection: A Systematic Review and Meta-analysis, Gastroenterology. 2019, 156: 635-646.e9.
Yeo Y.H., Ho H.J., Yang H.I., Tseng T.-.C., Trinh H.N., Park Y.M., Hosaka T., Fung J.Y.Y., Ungtrakul T., Yu M.L., Li J., Zhang J., Le A.K., Sriprayoon T., Yuen R.M.F., Lee H.S., Suzuki F., Kobayashi M., Kao J.H., Wu C.-.Y. and Nguyen M.H., Incidence and predictors of HBsAg seroclearance in 10,614 untreated patients on long-term follow-up: a collaborative study from North America and Asia Pacific, Hepatology. 2018, 68: 132A-133A.


Researcher : GUO C

List of Research Outputs

GUO C., Cheung K.S.M., Zhang F., Chan E.W.Y., Chen L., Wong I.C.K. and Leung W.K., Incidences, temporal trends and risks of hospitalisation for gastrointestinal bleeding in new or chronic low-dose aspirin users after treatment for Helicobacter pylori : a territory-wide cohort study , Gut. 2019, gutjnl-2019-318352.
GUO C., Chen L., Chan E.W.Y., Cheung K.S.M., Isshiki T., Wong I.C.K. and Leung W.K., Systematic review with meta- analysis: the risk of gastrointestinal bleeding in patients taking third-generation P2Y12 inhibitors compared with clopidogrel, Alimentary Pharmacology & Therapeutics. 2019.
Zimmermann-Fraedrich K., Sehner S., Rex D.K., Kaltenbach T., Soetniko R., Wallace M., Leung W.K., GUO C., Gralnek I.M., Brand E.C., Growth S., Schachschai G., Ikematsu H., Siersema P.D. and Rosch T., Right-Sided Location Not Associated With Missed Colorectal Adenomas in an Individual-Level Reanalysis of Tandem Colonoscopy Studies, Gastroenterology. 2019.


Researcher : Ge M

List of Research Outputs

Lee Y.K.M., Ge M., Fung M.L., Vanhoutte P.M.G.R., Mak J.C.W. and Ip M.S.M., Low but not high frequency of intermittent hypoxia suppresses endothelium-dependent, oxidative stress-mediated contractions in carotid arteries of obese mice, Journal of Applied Physiology. 2018, 125: 1384-1395.
Wong S.M., Lam W., Ge M., Yeung S.C., Liang Y., Ip M.S.M. and Mak J.C.W., Cardiac and Pulmonary Inflammatory Responses by Intermittent Hypoxia in C57BL/6N and C57BL/6J Mouse Strains, 24th Medical Research Conference, Department of Medicine, HKU, Hong Kong Medical Journal. 2019, 25: 32.
Yeung S.C., Ge M., Mak J.C.W. and Ip M.S.M., Differential effects of intermittent hypoxia on systemic and adipose tissue inflammation in lean and diet-induced obese mice, 24th Medical Research Conference, Department of Medicine, HKU, January 2019. Hong Kong Medical Journal. 2019, 25 (Suppl 1): 45.


Researcher : Geng L

List of Research Outputs

Geng L., Liao B., Jin L., Huang Z., Triggle C., Hong D., Zhang J., Huang Y., Lin Z. and Xu A., Exercise Alleviates Obesity-Induced Metabolic Dysfunction via Enhancing FGF21 Sensitivity in Adipose Tissues, In: Stephen Matheson, Cell Reports. Cambridge, Massachusetts, U.S., Cell Press, 2019, 26: 2738-2752.E4.


Researcher : HAN S

List of Research Outputs

JIANG D., XIONG G., FENG H., ZHANG Z., Chen P., Yan B., CHEN L., Kesavamoorthy G., MA C.Y., Li C., HAN S., Zhang Y., Liao C., Lee T.L., Tse H.F., Fu Q.L., Chiu K. and Lian Q., Donation of mitochondria by iPSC-derived mesenchymal stem cells protects retinal ganglion cells against mitochondrial complex I defect-induced degeneration, Theranostics. Australia, Ivyspring International Publisher, 2019, 2019, Vol. 9, Issue 8: 2395-2410.


Researcher : Hai SHJJ

Project Title:Effect of a Glucagon-Like Peptide-1 (GLP-1) Receptor Agonist on Hypertension-Induced Atrial Remodelling
Investigator(s):Hai SHJJ, Tse HF
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research for New Staff
Start Date:06/2016


List of Research Outputs

Chan Y.H., Hai S.H.J.J. and Tse H.F., Malignant Arrhythmia in a 40-Year-Old Man, JAMA Cardiology. 2018, 3: 661.
Cheung Y.Y., Lee C.H.P., Tang S.M., Xu A., Au K.W., Fong H.Y., Ng K.K., KWOK H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Hai S.H.J.J., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Genetic regulation of Pigment Epithelium-Derived Factor (PEDF): an exome-chip association analysis in Chinese subjects with type 2 diabetes, Diabetes. 2019, 68: 198-206.
Feng X.F., Hai S.H.J.J., Ma Y., Wang Z.Q. and Tse H.F., Sudden Cardiac Death in Mainland China, Circulation: Arrhythmia and Electrophysiology. 2018, 11: e006684.
Hai S.H.J.J., Fang J., Tam C.C., Wong C.K., Un C.K., Siu D.C.W., Lau C.P. and Tse H.F., Safety and feasibility of a midseptal implantation technique of a leadless pacemaker, Heart Rhythm. 2019, 16: 896-902.
Huang D., Cheng Y., Wong Y.T.A., Yung S.A., Tam C.C., Chan K.W.K., Lam C.C.S., Yiu K.H., Hai S.H.J.J., Lau C.P., Chan E.W.Y., Chiang C.E., Wong K.L., Cheung T.T., Cheung B.M.Y., Feng Y.Q., Tam N., Chen J.Y., Yue W.S., Hu H.X., Chen L., Tse H.F., Chan P.H.M. and Siu D.C.W., Thrombolysis in myocardial infarction risk score for secondary prevention of recurrent cardiovascular events in a real-world cohort of post-acute myocardial infarction patients, Circulation. 2019, 83(4): 809-817.
Lau C.P., Hai S.H.J.J. and Siu D.C.W., Implantable cardioverter defibrillators in Asian population, Pacing and Clinical Electrophysiology. 2018, 41: 1627-1629.
Wong Y.K., Cheung Y.Y., Tang S.M., Au K.W., Hai S.H.J.J., Lee C.H.P., Lau G.K.K., Cheung B.M.Y., Sham P.C., Xu A., Lam K.S.L. and Tse H.F., Age-Biomarkers-Clinical Risk Factors for Prediction of Cardiovascular Events in Patients With Coronary Artery Disease., Arterioscler Thromb Vasc Biol. American Heart Association, Inc., 2018, 38: 2519-2527.
Zhan X.Z., Liu F.Z., Guo H.M., Liao H.T., Fang X.H., Liu J., Deng H., Huang H.L., Hai S.H.J.J., Tse H.F., Li Y.Q., Xue Y.M. and Wu S.L., Characteristics, Mechanism and Long-Term Ablation Outcome of Atrial Tachycardias After Mitral Valvular Surgery and Concomitant Cox-MAZE IV Procedure., International Heart Journal. 2019, 60(1): 71-77.


Researcher : Ho JCM

Project Title:MERIT – A phase II marker identification trial for TarcevaTM in second line NSCLC patients
Investigator(s):Ho JCM
Department:Medicine
Source(s) of Funding:F Hoffmann-La Roche and Co. Ltd. - General Award
Start Date:07/2005


Project Title:A Phase III, radonmized, double-blinded, parallel group, multi centre study to access the efficacy and safety of ZD6474 (ZACTIMA TM) in combination with pemetrexed (Alimta) versus pemetrexed alone in patients with locally-advanced or metastatic (stage IIIB or IV) non-small cell lung cancer (NSCLC) after failure of 1st line anti-cancer therapy
Investigator(s):Ho JCM, Wong KYM
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:02/2007


Project Title:A rabdomized, double blind, placebo controlled, phase IIIB trial comparing bevacizumab therapy with or without erlotinib after completion of chemotherapy with bevacizumab for the first line treatment of locally advanced, recurrent, or metastatic non-small cell lung cancer
Investigator(s):Ho JCM
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:08/2007


Project Title:The effect of inhaled corticosteroids on the risk of diabetes, impaired glucose tolerance and characteristics of glucose regulation in adults with asthma: a population based matched controlled study
Investigator(s):Ho JCM
Department:Medicine
Source(s) of Funding:Lee Wing Tat Fund
Start Date:08/2007


Project Title:A Phase 3, multicentre, randomized, placebo-controlled, double-bind trial of AMG 706 in combination with paclitaxel and carboplatin for advanced non-small cell lung cancer
Investigator(s):Ho JCM
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:11/2007


Project Title:A phase III, randomized, double-blind, active-controlled, parallel-group study, conducted under in-house building conditions, to examine the safety, tolerability, and efficacy of a single dose of intravenous MK-0517 for the prevention of chemotherapy-induced nausea and vomiting (CINV) associated wtih Cisplatin chemotheray
Investigator(s):Ho JCM
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:06/2008


Project Title:A randomized, multicenter phase II study to explore whether biomarkers correlate with treatment outcome in chemo-naive patients with advanced or recurrent non-squamous non-small cell lung cancer, who receive treatment with bevacizumab (at a dose of either 7,5mg.kg or 15mg/kg) in addition to carboplain-based chemotherapy (gemcitabine or paclitaxed)
Investigator(s):Ho JCM
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:12/2008


Project Title:In-vitro combination of arsenic trioxide and chemotherapy in non-small cell lung cancer
Investigator(s):Ho JCM
Department:Medicine
Source(s) of Funding:Hong Kong Lung Foundation Research Grant
Start Date:02/2009


Project Title:A randomised, placebo-controlled, double-blind phase III study of sequential administration of Tarceva (erlotinib) or placebo in combination with gemcitabine/platinum as first-line treatment in patients with stage IIIB/V non-small cell lung cancer (NSCLC)
Investigator(s):Ho JCM
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:04/2009


Project Title:Multicenter, randomized, double-blind, phase III trial to investigate the efficacy and safety of oral BIBF 1120 plus standard pemetrexed therapy compared to placebo plus standard pemetrexed therapy in patients with stage IIIB/IV or recurrent non small cell lung cancer after failure of first line chemotherapy
Investigator(s):Ho JCM
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:04/2009


Project Title:A Phase III, multi-center, placebo–controlled trial of Sorafenib (BAY 43-9006) in patients with relapsed or refractory advanced predominantly non squamous Non-Small Cell Lung Cancer (NSCLC) after 2 or 3 previous treatment regimens.
Investigator(s):Ho JCM, Lam CLD, Lam CMJ, Wang KLJ, Wong KYM
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:08/2009


Project Title:Phase 3, randomized, open-label study of the efficacy and safety of PF-02341066 versus standard of care chemotherapy (pemetrexed or docetaxel) in patients with advanced nonsmall cell lung cancer (NSCLC) harbouring a translocation or inversion event involving the anaplastic lymphoma kinase (ALK) gene locus
Investigator(s):Ho JCM, Lam CLD, Wong KYM, Lam CMJ, Ip MSM
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:04/2010


Project Title:Phase 2, open-label single arm study of the efficacy and safety of PF 02341066 in patients with advanced non-small cell lung cancer (NSCLC) harboring a translocation or inversion involving the anaplastic lymphoma kinase (ALK) gene locus
Investigator(s):Ho JCM, Lam CLD, Wong KYM, Lam CMJ, Ip MSM
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:04/2010


Project Title:Randomized controlled trial of S-1 versus docetaxel in patients with non-small cell lung cancer who have received a platinum-based treatment
Investigator(s):Ho JCM, Lam CLD
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:08/2010


Project Title:In-vitro combination of arsenic trioxide and chemotherapy in non-small cell lung cancer
Investigator(s):Ho JCM
Department:Medicine
Source(s) of Funding:The Hong Kong Anti-Cancer Society (HKACS) - General Award
Start Date:03/2011


Project Title:A Randomized, Double-Blind, Phase 2 Study of erlotinib (Tarceva®) in combination with OSI 906 or placebo in Chemonaive Patients with Advanced NSCLC with Activating Mutations of the Epidermal Growth Factor Receptor (EGFR) Gene
Investigator(s):Ho JCM, Lam CLD
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:04/2011


Project Title:Randomized, Multicenter, Double-Blind, Phase 3 Trial Comparing the Efficacy of Ipilimumab in Addition to Paclitaxel and Carboplatin versus Placebo in Addition to Paclitaxel and Carboplatin in Subjects with Stage IV/Recurrent Non-Small Cell Lung Cancer (NSCLC)
Investigator(s):Ho JCM, Lam CLD
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:05/2011


Project Title:In vitro study of arsenic trioxide in treatment of malignant pleural mesothelioma
Investigator(s):Ho JCM, Lam SK
Department:Medicine
Source(s) of Funding:Pneumoconiosis Compensation Fund Board - General Award
Start Date:07/2011


Project Title:A Phase III Randomised, Double blind, Placebo controlled, Parallel, Multicentre Study to Assess the Efficacy and Safety of continuing IRESSATM 250 mg in addition to Chemotherapy versus Chemotherapy alone in Patients who have Epidermal Growth Factor Receptor (EGFR)Mutation Positive Locally advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) and have progressed on First Line IRESSATM
Investigator(s):Ho JCM, Lam CLD
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:02/2012


Project Title:In vitro and in vivo study of arginase in treatment of malignant pleural mesothelioma
Investigator(s):Ho JCM, Lam SK
Department:Medicine
Source(s) of Funding:Pneumoconiosis Compensation Fund Board - General Award
Start Date:07/2015


List of Research Outputs

Ho J.C.M. and Leung C.C., Management of co-existent tuberculosis and lung cancer, Lung Cancer. 2018, 122: 83-87.
Hsin M.K. and Ho J.C.M., It is not as bad as they say: The risks of surgery in screening-detected lung cancer are overstated. , J Thorac Cardiovasc Surg . Elsevier, 2019, 157: 2047-2048.
Kwok W.C., Ho J.C.M., Lam C.L.D., Lui M.S.M., Ip M.S.M. and Tam C.C.T., Efficacy of gefitinib at reduced dose in EGFR mutant non-small-cell lung carcinoma., 24th Medical Research Conference, Department of Medicine, HKU. Hong Kong Medical Journal. 2019, 25 (Suppl 1): 24.
Kwok W.C., Ho J.C.M., Lam C.L.D., Lui M.S.M., Ip M.S.M. and Tam C.C.T., Progression-free survival among progressed non-small-cell lung cancer with T790M mutation as guided by liquid versus tissue re-biopsy, 24th Medical Research Conference, Department of Medicine, HKU. Hong Kong Medical Journal. 2019, 25 (Suppl 1): 25.
Lam S.K., Yan S., XU S., U K.P., Cheng P.N. and Ho J.C.M., Endogenous arginase 2 as a potential biomarker for PEGylated arginase 1 treatment in xenograft models of squamous cell lung carcinoma , Oncogenesis. 2019, 8: 18.
Lam S.K., U K.P., Li Y.V., XU S., Cheng P.N. and Ho J.C.M., Inhibition of ornithine decarboxylase 1 facilitates pegylated arginase treatment in lung adenocarcinoma xenograft models, Oncology Reports. 2018.
Lam S.K., Yan S., XU S. and Ho J.C.M., Targeting polyamines as potential adjuvant therapy in malignant pleural mesothelioma xenograft models, IASLC 19th World Conference on Lung Cancer. 2018.
Lam S.K., Yan S., XU S. and Ho J.C.M., Targeting polyamines as potential adjuvant therapy in malignant pleural mesothelioma xenograft models, 24th Medical Research Conference. Medical Journal, 2019, 25: 26.
Wong M.P., Xiao Z., Tin P.C. and Ho J.C.M., Uncovering Tyrosine Kinase Inhibitor Resistance Mutations In EGFR Mutant Lung Adenocarcinoma Using Whole Exome Sequencing, Cancer Genomics Conference. 2019.
Wu Y.L., Lu S., Lu Y., Zhou J.Y., Shui Y.K., Sriuranpong V., Ho J.C.M., Ong C.K., Tsai C.M., Chung C.H., Wilner K.D., Tang Y., Masters E.T., Selaru P. and Mok T.S., Results of PROFILE 1029, a Phase III Comparison of First-Line Crizotinib versus Chemotherapy in East Asian Patients with ALK-Positive Advanced Non–Small Cell Lung Cancer, Journal of Thoracic Oncology. 2018, 13: 1539-1548.
XU S., Lam S.K., Cheng P.N. and Ho J.C.M., Recombinant human arginase induces apoptosis via oxidative stress and cell cycle arrest in small cell lung cancer, Cancer Science. 2018, Epub ahead of print.


Researcher : Ho SL

Project Title:Biochemical markers in a large Chinese kindred with autosomal dominant motor neurone disease associated with SOD1 mutation
Investigator(s):Ho SL, Song Y, Wang Y
Department:Medicine
Source(s) of Funding:Liu Po Shan/Dr Vincent Liu Endowment Fund for Motor Neuron diseases - General Award
Start Date:04/2007


Project Title:Pathophysiological study of synaptic vesicle protein synaptogyrin3 (SYNGR3) in Parkinson’s disease
Investigator(s):Ho SL, Ho WL, Lam CSC
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:04/2018


List of Research Outputs

Ho W.L., Leung C.T.G., Liu H., Pang S.Y.Y., Lam C.S.C., Xian J., Li L., Kung M.H.W., Ramsden D.B. and Ho S.L., Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA), Autophagy. 2019, 1-24.
Ho W.L. and Ho S.L., Animal Models of Parkinson's Disease, 12th Congress of the Movement Disorder Society of Japan. Kyoto, Japan. (5-7 July 2018). 2018.
LI T.H., Hui S.K., Chan Q., Yao N., Chua S.E., McAlonan G.M., Pang S.Y.Y., Ho S.L. and Mak H.K.F., Quantitative susceptibility mapping as an indicator of subcortical and limbic iron abnormality in Parkinson's disease with dementia, NeuroImage: Clinical. 2018.


Researcher : Ho WL

Project Title:Neurotoxic effects of environmental estrogenic endocrine disruptive compounds on brain dopamine homeostasis
Investigator(s):Ho WL, Ho SL, Leung KMY
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:06/2015


Project Title:Therapeutic effects of brain-penetrable kinase inhibitors to prevent accumulation of pathogenic alpha-synuclein oligomers in Parkinson’s disease Parkinson’s disease
Investigator(s):Ho WL, Ho SL
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:04/2018


List of Research Outputs

Ho W.L., Leung C.T.G., Liu H., Pang S.Y.Y., Lam C.S.C., Xian J., Li L., Kung M.H.W., Ramsden D.B. and Ho S.L., Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA), Autophagy. 2019, 1-24.
Ho W.L. and Ho S.L., Animal Models of Parkinson's Disease, 12th Congress of the Movement Disorder Society of Japan. Kyoto, Japan. (5-7 July 2018). 2018.


Researcher : Hoo RLC

Project Title:The inter-relationship between A-FABF, endoplasmic reticulum stress and autophagy in the pathogenesis of obesity-induced imflammation
Investigator(s):Hoo RLC, Zhang J
Department:Medicine
Source(s) of Funding:National Natural Science Foundation of China (NSFC) - General Program
Start Date:01/2013


Project Title:Adipocyte fatty acid binding protein (A-FABP) is a potential therapeutic target of both alcoholic and non-alcoholic steatohepatitis
Investigator(s):Hoo RLC, Xu A
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:04/2015


Project Title:Adipocyte fatty acid binding protein (A-FABP) is a pathological mediator of obesity-related renal dysfunction.
Investigator(s):Hoo RLC, Xu A
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:06/2016
Completion Date:02/2019


Project Title:The role of lipid chaperone ap2 in regional adipose tissue expandability
Investigator(s):Hoo RLC, Xu A
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:04/2017
Completion Date:03/2019


Project Title:The roles of neutrophil elastase (NE) and proteinase 3 (PR3) in the conversion of white to brown adipocytes
Investigator(s):Hoo RLC, Xu A
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:06/2018


Project Title:Neutrophil serine proteases as the endogenous suppressors of white adipose tissue browning and adaptive thermogenesis
Investigator(s):Hoo RLC, Xu A
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2019


Project Title:The role of Syndecan-4 (Sdc4) in adipose tissue dysfunction
Investigator(s):Hoo RLC, Xu A
Department:Pharmacology & Pharmacy
Source(s) of Funding:Seed Fund for Basic Research
Start Date:06/2019


Project Title:Mitochondrial protein coiled-coil-helix-coiled-coil-helix domain 10 (Chchd10) as a novel factor for the treatment of obesity and its related diseases
Investigator(s):Hoo RLC, Xu A
Department:Pharmacology & Pharmacy
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:06/2019




Researcher : Hu HC

Project Title:A study to validate a symptom severity questionnaire for patents with functional dyspepsia
Investigator(s):Hu HC, Lam CLK
Department:Medicine
Source(s) of Funding:Health Services Research Fund - Full Grants
Start Date:10/1998




Researcher : Huang D

List of Research Outputs

BLAIS J.E., Chan E.W.Y., Law W.Y., Mok M.T., Huang D., Wong I.C.K. and Siu D.C.W., Trends in statin prescription prevalence, initiation, and dosing: Hong Kong, 2004–2015, Atherosclerosis. 2018, 280: 174-182.
Huang D., Cheng Y., Wong Y.T.A., Yung S.A., Tam C.C., Chan K.W.K., Lam C.C.S., Yiu K.H., Hai S.H.J.J., Lau C.P., Chan E.W.Y., Chiang C.E., Wong K.L., Cheung T.T., Cheung B.M.Y., Feng Y.Q., Tam N., Chen J.Y., Yue W.S., Hu H.X., Chen L., Tse H.F., Chan P.H.M. and Siu D.C.W., Thrombolysis in myocardial infarction risk score for secondary prevention of recurrent cardiovascular events in a real-world cohort of post-acute myocardial infarction patients, Circulation. 2019, 83(4): 809-817.


Researcher : Huang FY

List of Research Outputs

LIU F., ZHANG S., Huang F.Y., Wong D.K.H., Mak L.Y., Cheung K.S.M., Lai C.L., Yuen R.M.F. and Seto W.K.W., Characterization of regulatory T cells and the role of PD-1 and TNF-alpha in spontaneous hepatitis B surface antigen seroclearance in chronic hepatitis B, JOURNAL OF HEPATOLOGY. ELSEVIER SCIENCE BV PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, 2019, 70: E454-E455.
LIU F., ZHANG S., Huang F.Y., Wong D.K.H., Mak L.Y., Cheung K.S.M., Lai C.L., Yuen R.M.F. and Seto W.K.W., Characterization of regulatory T cells and the role of PD-1 and TNF-alpha in spontaneous hepatitis B surface antigen seroclearance in chronic hepatitis B, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2019, 701: E454-455.
LIU F., Seto W.K.W., Wong D.K.H., Huang F.Y., Cheung K.S.M., Mak L.Y., Sharma R., ZHANG S., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Plasma fibronectin levels identified via quantitative proteomics profiling predicts hepatitis B surface antigen seroclearance in chronic hepatitis B, The Journal of Infectious Diseases. 2019, 220(6): 940-950.
Liu F., Seto W.K.W., Wong D.K.H., Huang F.Y., Mak L.Y., Cheung K.S.M., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Serum Fibronectin Levels Identified Via Proteomics Profiling Predict Spontaneous Hepatitis B Surface Antigen Seroclearance in Chronic Hepatitis B, HEPATOLOGY. WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2018, 68: 1185A-1186A.
ZHANG S., LIU F., Huang F.Y., Wong D.K.H., Lai C.L., Yuen R.M.F. and Seto W.K.W., The role of Paneth cells in the pathogenesis of non-alcoholic fatty liver disease: A potential gut microbiota-associated mechanism, JOURNAL OF HEPATOLOGY. ELSEVIER SCIENCE BV PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, 2019, 70: E553-E553.
zhang L.F., Mao M.Y., Ye W., Yang Y.T., Leung W.K., Chu K.M., Huang F.Y. and Todsico A.N.D.R.E.A., REGULATION OF THE BMP SIGNALING INHIBITOR SMAD6 IN GASTRITIS AND GASTRIC CANCER, DDW 2019. 156: S-273.


Researcher : Huang Z

Project Title:Targeting G protein-coupled receptor 110 for the treatment of obesity and non-alcoholic fatty liver disease
Investigator(s):Huang Z, Xu A
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:05/2019


List of Research Outputs

Geng L., Liao B., Jin L., Huang Z., Triggle C., Hong D., Zhang J., Huang Y., Lin Z. and Xu A., Exercise Alleviates Obesity-Induced Metabolic Dysfunction via Enhancing FGF21 Sensitivity in Adipose Tissues, In: Stephen Matheson, Cell Reports. Cambridge, Massachusetts, U.S., Cell Press, 2019, 26: 2738-2752.E4.


Researcher : Hui CK

Project Title:Significance of occult hepatitis B infection in patients undergoing autologous HSCT
Investigator(s):Hui CK, Liang HSR, Lau G, Lie AKW
Department:Medicine
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:10/2006




Researcher : Hui KMC

List of Research Outputs

North C.M., Rice M.A.R.Y. .B., Ferkol T.H.O.M.A.S., Gozal D.A.V.I.D., Hui K.M.C., Jung S.O.O.N.-.H.E.E., Kuribayashi K.O.Z.O., McCormack M.E.R.E.D.I.T.H. .C., Mishima M.I.C.H.I.A.K.I., Morimoto Y.A.S.U.O., Song Y.U.A.N.L.I.N., Wilson K.E.V.I.N. .C., Kim W.O.O. .J.I.N. and Fong K.W.U.N. .M., Air pollution in the Asia‐Pacific Region, Respirology. 2019, 24: 484-491.
North C.R.Y.S.T.A.L. .M., Rice M.A.R.Y. .B., Ferkol T.H.O.M.A.S., Gozal D.A.V.I.D., Hui K.M.C., Jung S.O.O.N.-.H.E.E., Kuribayashi K.O.Z.O., McCormack M.E.R.E.D.I.T.H. .C., Mishima M.I.C.H.I.A.K.I., Morimoto Y.A.S.U.O., Song Y.U.A.N.L.I.N., Wilson K.E.V.I.N. .C., Kim W.O.O. .J.I.N. and Fong K.W.U.N. .M., Air Pollution in the Asia-Pacific Region. A Joint Asian Pacific Society of Respirology/American Thoracic Society Perspective, American Journal of Respiratory and Critical Care Medicine. 2019, 199: 693-700.
Shih K.C., Choy N.K.B., Ho W.L., Shum J.W.H., Lai J.S.M., Huang R., Hui K.M.C. and Ip M.S.M., Incidence of Normal Tension Glaucoma Among Chinese Patients with Treatment Naïve Obstructive Sleep Apnea Syndrome, 2019 Annual Meeting of the Asia Pacific Academy of Ophthalmology. 2019.
Xu P., Hui K.M.C., Lui M.S.M., Lam C.L.D., Fong D.Y.T. and Ip M.S.M., Incident Type 2 Diabetes in OSA and Effect of CPAP Treatment, Chest. 2019.


Researcher : Hui X

Project Title:SIRT1 in perivascular adipose tissues(PVAT) as a mediator of obesity-induced endothelial dysfunction by controlling brown-to-white transition of PVAT: Molecular mechanisms and therapeutic interventions
Investigator(s):Hui X, Vanhoutte PMGR
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:04/2015
Completion Date:10/2018


Project Title:The non-canonical thermoregulatory pathways in uncoupling protein-1 (UCP1) independent manner
Investigator(s):Hui X, Xu A
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research for New Staff
Start Date:06/2017
Completion Date:06/2019


Project Title:Lactate produced in adipose tissue as a culprit of obesity-related metabolic complications: mechanisms and clinical implications
Investigator(s):Hui X, Xu A
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:06/2018


Project Title:The role of Annexin A8 in adipose and systemic metabolism
Investigator(s):Hui X
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:06/2018


Project Title:Mechanisms of Metabolic Signaling; Adipocyte-derived lactate enhances adipose tissue inflammation
Investigator(s):Hui X
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:05/2019


Project Title:The new function of AMPKgamma2 subunit in determining adipocyte and adipose tissue function
Investigator(s):Hui X
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:06/2019


List of Research Outputs

Li H., Wu G., Fang Q., Zhang M., Hui X., Sheng B., Wu L., Bao Y., Li P., Xu A. and Jia W., Fibroblast growth factor 21 increases insulin sensitivity through specific expansion of subcutaneous fat, Nature Communications. 2018, 9.
Pan Y., Hui X., Hoo R.L.C., Ye D., Chan C.Y.C., Feng T., Wang Y., Lam K.S.L. and Xu A., Adipocyte-secreted Exosomal Microrna-34a Inhibits M2 Macrophage Polarization To Promote Obesity-induced Adipose Inflammation, Journal of Clinical Investigation. 2019, 129: 834-849.


Researcher : Hui YLE

Project Title:Genetic markers of severe diabetic retinopathy in Southern Chinese subjects with type 2 diabetes
Investigator(s):Hui YLE, Lam KSL, Xu A, Wong DSH, Cheung YY, Chan JTJ
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research for New Staff
Start Date:03/2013




Researcher : Hung FNI

Project Title:Treatment of severe influenza A infection with celecoxib: a double blind randomized controlled trial
Investigator(s):Hung FNI, To KKW, Chan JFW, Chan KH, Yuen KY
Department:Medicine
Source(s) of Funding:Commissioned Studies on Emerging Influenza A Viruses with Epidemic Potential
Start Date:12/2014


Project Title:A double-blind randomized controlled trial of 13-valent pneumococcal conjugated vaccine in patients with chronic illness
Investigator(s):Hung FNI, Chan KH
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:04/2015
Completion Date:06/2019


Project Title:Intrademal quadrivalent influenza vaccine with topical imiquimod in elderly & chronic illness subjects, a double-blind randomized controlled tria
Investigator(s):Hung FNI, Yuen KY, Cheng CCV, Chan KH
Department:Medicine
Source(s) of Funding:Commissioned Study on Influenza Vaccine with Imiquimod in Elderly and Chronic Illness Subjects
Start Date:06/2019


List of Research Outputs

Chan J.F.W., Yuen K.Y. and Hung F.N.I., Commissioned study on conducting tests for Zika virus among asymptomatic people returning from the 2016 Olympic Games and Paralympic Games, Health Research Symposium 2019.
Chen J.Y., Lam T.P., Hung F.N.I., Chan A.C.Y., Chin W.Y., See C.Y.H. and Tsang J.P.Y., A pilot project on medical students as peer tutors: Perspectives from stakeholders, Frontiers in Medical and Health Sciences Education. 2018.
Hung F.N.I., Wong D.K.H., Seto W.K.W., Fung J.Y.Y., Yuen K.Y. and Yuen R.M.F., A Double-Blind Randomized Controlled Trial of Intradermal Hepatitis B Vaccination with Topical Imiquimod in Subjects with Occult Hepatitis B Infection, HEPATOLOGY. WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2018, 68: 255A-256A.
Hung F.N.I., Becoming Health Care Professionals Summer School - Understanding the Professional Roles and Responsibilities of Doctors, Guest talk in the Summer School 2018 organized by HKUSPACE. 2018.
Hung F.N.I., Burden of Influenza in the different age groups, 2nd WAidid Congress in Milan, Italy on 19 October 2018 . 2018.
Hung F.N.I., Clinical Medicine Teaching, Executive Training Programme on Hong Kong Higher Education Management for Wannan Medical College organized by HKUSPACE on 3 July 2018, 2018.
Hung F.N.I., Hepatitis C (chair the session), Beijing/Hong Kong Medical Exchange Conference 20-21 October 2018 organized by Hong Kong Medical Association . 2018.
Hung F.N.I., Inflammatory bowel disease related infection and prevention, 8th Annual Scientific Meeting of Macao Society of Gastroenterology & Hepatology . 2018.
Hung F.N.I., Novel Influenza Vaccine - Long Overdue , 17th Asia-Pacific Congress of Clinical Microbiology and Infection cum 8th International Infection Control Conference . 2018.
Hung F.N.I., Update of Influenza Vaccination, Lunch seminar on seasonal flu and LAIV for Hong Kong Medical Association Members organized by AstraZeneca Hong Kong Limited . 2018.
Lam Y.F., Seto W.K.W., Tong S.M., Cheung K.S.M., Lo O.S.H., Hung F.N.I., Law W.L. and Leung W.K., Rates of metachronous adenoma after curative resection for left-sided or right-sided colon cancer, Intestinal Research. 2018, 16: 619-627.
Li C., To K.K.W., Zhang J., Lee C.Y., Zhu H., Mak W.N., Hung F.N.I. and Yuen K.Y., Co-stimulation With TLR7 Agonist Imiquimod and Inactivated Influenza Virus Particles Promotes Mouse B Cell Activation, Differentiation, and Accelerated Antigen Specific Antibody Production., Frontiers in Immunology. 2018, 9.
Lui G., Tam A., Tso E.Y.K., Wu A.K.L., Zee J., Choi K.W., Lam W., Chan M.C., Ting W.M. and Hung F.N.I., Melioidosis in Hong Kong, Tropical Medicine and Infectious Disease . 2018, 3(3): pii.E91.
Zhang J., ZHU H., Chen Y., LI C., Li C., Gozali L., Lee C.Y., To K.K.W., Hung F.N.I. and Yuen K.Y., Prostaglandin E2-mediated impairment of innate immune response to A(H1N1)pdm09 infection in diet-induced obese mice could be restored by paracetamol , Journal of Infectious Diseases. 2018.


Researcher : Hung I.F.N.

Project Title:Treatment of severe influenza A infection with celecoxib: a double blind randomized controlled trial
Investigator(s):Hung FNI, To KKW, Chan JFW, Chan KH, Yuen KY
Department:Medicine
Source(s) of Funding:Commissioned Studies on Emerging Influenza A Viruses with Epidemic Potential
Start Date:12/2014


Project Title:A double-blind randomized controlled trial of 13-valent pneumococcal conjugated vaccine in patients with chronic illness
Investigator(s):Hung FNI, Chan KH
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:04/2015
Completion Date:06/2019


Project Title:Intrademal quadrivalent influenza vaccine with topical imiquimod in elderly & chronic illness subjects, a double-blind randomized controlled tria
Investigator(s):Hung FNI, Yuen KY, Cheng CCV, Chan KH
Department:Medicine
Source(s) of Funding:Commissioned Study on Influenza Vaccine with Imiquimod in Elderly and Chronic Illness Subjects
Start Date:06/2019


List of Research Outputs



Researcher : Hung IFN

Project Title:Treatment of severe influenza A infection with celecoxib: a double blind randomized controlled trial
Investigator(s):Hung FNI, To KKW, Chan JFW, Chan KH, Yuen KY
Department:Medicine
Source(s) of Funding:Commissioned Studies on Emerging Influenza A Viruses with Epidemic Potential
Start Date:12/2014


Project Title:A double-blind randomized controlled trial of 13-valent pneumococcal conjugated vaccine in patients with chronic illness
Investigator(s):Hung FNI, Chan KH
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:04/2015
Completion Date:06/2019


Project Title:Intrademal quadrivalent influenza vaccine with topical imiquimod in elderly & chronic illness subjects, a double-blind randomized controlled tria
Investigator(s):Hung FNI, Yuen KY, Cheng CCV, Chan KH
Department:Medicine
Source(s) of Funding:Commissioned Study on Influenza Vaccine with Imiquimod in Elderly and Chronic Illness Subjects
Start Date:06/2019


List of Research Outputs



Researcher : Hwang YYG

List of Research Outputs

Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Mak L.Y., Wong D.K.H., Fung J.Y.Y., Liu S.H.K., Cheung K.S.M., Lai C.L., Kwong Y.L. and Yuen R.M.F., Monitoring and Treatment of Patients Undergoing Immunotherapy With Anti-CD20 Who are Exposed to HBV, Clinical Gastroenterology and Hepatology. 2018, 17(7): 1410-1412.
Singh G.H.H., Kumana C.R., Yim R.L.H., Hwang Y.Y.G., Chan S.Y.T., Yip S.F., Lee H.K.K., Mak V., Lau J.S.M., Chan C.C., Kho B., Wong R.S.M., Li W., Lin S.Y., Lau C.K., Ip H.W., Leung R.Y.Y., Lam C.C.K. and Kwong Y.L., Oral arsenic trioxide incorporation into frontline treatment with all‐trans retinoic acid and chemotherapy in newly diagnosed acute promyelocytic leukemia: A 5‐year prospective study, Cancer. 2019.


Researcher : Ip MSM

Project Title:The efficacy of the modified oral appliance in the treatment of mild and moderate obstructive Sleep Apnoea
Investigator(s):Ip MSM
Department:Medicine
Source(s) of Funding:Other Funding Scheme
Start Date:02/1997


Project Title:The effect of oral appliance (OA) in treatment of obstructive sleep apnoea
Investigator(s):Ip MSM, Peh WCG, Cooke MS
Department:Medicine
Source(s) of Funding:Other Funding Scheme
Start Date:06/1997


Project Title:Role of adiponectin in obstructive sleep apnoea
Investigator(s):Ip MSM, Lam KSL
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2002


Project Title:Candidate genes of obstructive sleep apnoea syndrome in Hong Kong Chinese
Investigator(s):Ip MSM, Lam KSL, Song Y, Sham PC
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:01/2005


List of Research Outputs

Au Y.N.E., Liang Y., Ip M.S.M., Zhang Y. and Mak J.C.W., Effects of Dendrobium officinale Polysaccharides in Cigarette Smoke-induced Inflammation in Human Airway Epithelial NCI-H292 Cells, 24th Medical Research Conference, Department of Medicine, HKU, Hong Kong Medical Journal. Hong Kong Medical Jouranal, 2019, 25: 9.
CHEN R., Ip M.S.M. and Mak J.C.W., Effect of cigarette smoke on airway inflammation and mucus hypersecretion in submerged and well-differentiated airway epithelial cells, 24th Medical Research Conference, Department of Medicine, HKU. Hong Kong Medical Journal. 2019, 25 (Suppl 1): 11.
CHEN R., Yeung S.C., Ip M.S.M. and Mak J.C.W., The Role of ORMDL3 in Cigarette Smoke-induced Airway Injury, American Thoracic Society (ATS) and International Society of Respiratory Diseases (ISRD). 2019, 199: A3759.
CHEN R., Yeung S.C., Ip M.S.M. and Mak J.C.W., The role of ORMDL3 in cigarette smoke-induced airway injury, American Thoracic Society (ATS) International Conference 2019. 199: A3759.
Han Q., Yeung S.C., Ip M.S.M. and Mak J.C.W., Dysregulation of cardiac lipid parameters in high-fat high-cholesterol diet-induced rat model, Lipids Health Dis. 2018, 17: 255.
Ip M.S.M. and Mokhlesi B., Activating Leptin Receptors in the Central Nervous System Using Intranasal Leptin. A Novel Therapeutic Target for Sleep-disordered Breathing, American Journal of Respiratory and Critical Care Medicine. 2019, 199: 689-691.
Ip M.S.M., Cardiometabolic aspects and other conditions associated with OSA, HKTS / CHEST Delegation Hong Kong & Macau Advanced Course on Sleep and Breathing cum Annual Scientific Meeting, Hong Kong, Mar 2019. 2019.
Ip M.S.M., Chairman, Changing treatment landscape of chronic hepatitis B (Plenary Lecture), 2018 Hong Kong-Beijing-Taiyuan Medical Forum, Taiyuan, China, Sep 2018. 2018.
Ip M.S.M., Chairperson - Symposium I, HKTS / CHEST Delegation Hong Kong & Macau Advanced Course on Sleep and Breathing cum Annual Scientific Meeting, Hong Kong, Mar 2019. 2019.
Ip M.S.M., Co-chairman - OSA and CSA : from basic to clinical practice, 4th International Congress on Respiratory Disease, Guangzhou, China, May 2019. 2019.
Ip M.S.M., Co-chairperson - Debate on Hot Topics in Sleep & Respiratory Failure, HKTS / CHEST Delegation Hong Kong & Macau Advanced Course on Sleep and Breathing cum Annual Scientific Meeting, Hong Kong, Mar 2019. 2019.
Ip M.S.M., Co-chairperson, Respiratory Grand Round: Challenging Cases, Autumn Respiratory Seminar cum Symposium and Hands-On Workshop on Pleural Diseases, HKTS / CHEST Delegation Hong Kong & Macau, Hong Kong, Nov 2018. 2018.
Ip M.S.M., Co-chairperson, Symposium 5: Battle of the titans: Where do we go from here?, HKTS & CHEST Delegation Hong Kong & Macau Symposium on Asthma and COPD, Hong Kong, Sep 2018. 2018.
Ip M.S.M., Co-chairperson, Symposium on Sleep disordered breathing, East West Alliance in Sleep Medicine and 1st China-Israel International Sleep Medicine Symposium, Shantou, China, Nov 2018. 2018.
Ip M.S.M., Local experience with interstitial lung disease, The University of Chicago, Symposium of Interstitial Lung Disease (ILD): Diagnosis and Management. Hong Kong, Apr 2019. 2019.
Ip M.S.M., Member of Advisory Board, Sleep and Biological Rhythms. 2019.
Ip M.S.M., Member of Editorial Board, Journal of Thoracic Disease. 2019.
Ip M.S.M., Member of Editorial Board, Sleep Medicine. 2018.
Ip M.S.M., Member of Editorial Board, Sleep Medicine Research of Korean Society of Sleep Medicine. 2019.
Ip M.S.M., Obstructive sleep apnea and Glucose metabolism, East West Alliance in Sleep Medicine & 1st China-Israel International Sleep Medicine Symposium, Shantou, China, Nov 2018. 2018.
Ip M.S.M., Prevention of cardiometabolic complications in obstructive sleep apnea – An achievable goal?, 4th International Congress on Respiratory Disease, Guangzhou, China, May 2019. 2019.
Kwok H.H., Lee C.M.N., Deng J., Ip M.S.M. and Lam C.L.D., Lung cancer patient–derived organoid biobank for therapeutic screening, 24th Medical Research Conference, Department of Medicine, HKU, Feb 2019. Hong Kong Medical Journal. 2019, 25 (Suppl.1): 24.
Kwok H.H., NING Z., Chong W.C., Wan T.S.K., Ng M.H.L., Ho G.Y.F., Ip M.S.M. and Lam C.L.D., Transfer of Extracellular Vesicle-Associated-RNAs Induces Drug Resistance in ALK-Translocated Lung Adenocarcinoma, In: Prof. Samuel C. Mok, Cancers. Basel, Switzerland, MDPI, 2019, 11: 104.
Kwok W.C., Ho J.C.M., Lam C.L.D., Lui M.S.M., Ip M.S.M. and Tam C.C.T., Efficacy of gefitinib at reduced dose in EGFR mutant non-small-cell lung carcinoma., 24th Medical Research Conference, Department of Medicine, HKU. Hong Kong Medical Journal. 2019, 25 (Suppl 1): 24.
Kwok W.C., Ho J.C.M., Lam C.L.D., Lui M.S.M., Ip M.S.M. and Tam C.C.T., Progression-free survival among progressed non-small-cell lung cancer with T790M mutation as guided by liquid versus tissue re-biopsy, 24th Medical Research Conference, Department of Medicine, HKU. Hong Kong Medical Journal. 2019, 25 (Suppl 1): 25.
Kwok W.C., Tam C.C.T., Lam C.L.D., Ip M.S.M. and Lui M.S.M., Pulmonary embolism developing after therapeutic drainage of malignant pleural effusions, Respiratory Medicine Case Reports. 2018, 25: 122-123.
Kwok W.C., Liang B.M., Lui M.S.M., Tam C.C.T., Sim P.Y.J., Tse E.W.C., Leung A.Y.H., Kwong Y.L., Lie A.K.W., Ip M.S.M. and Lam C.L.D., Rapid versus gradual lung function decline in bronchiolitis obliterans syndrome after haematopoietic stem cell transplantation is associated with survival outcome, Respirology. 2019, 24: 459-466.
Lam C.L.D. and Ip M.S.M., Sleep apnoea and immune regulation: The story is only beginning, Respirology. 2019, 24: 624-625.
Lee Y.K.M., Ge M., Fung M.L., Vanhoutte P.M.G.R., Mak J.C.W. and Ip M.S.M., Low but not high frequency of intermittent hypoxia suppresses endothelium-dependent, oxidative stress-mediated contractions in carotid arteries of obese mice, Journal of Applied Physiology. 2018, 125: 1384-1395.
Li S.M., Fong D.Y.T., Wong J.Y.H., Wilkinson K., Shapiro C., Choi P.H., McPherson D.B., Lam C.L.K. and Ip M.S.M., Nonrestorative sleep scale: reliable and valid for the Chinese population, Quality of Life Research. 2019, 28: 1685-1692.
Liang Y., Ip M.S.M. and Mak J.C.W., (-)-Epigallocatechin-3-gallate suppresses cigarette smoke-induced inflammation in human cardiomyocytes via ROS-mediated MAPK and NF-κB pathways, Phytomedicine. 2019.
Liang Y., Ip M.S.M. and Mak J.C.W., Congress Bursary for 18th World Congress of Basic And Clinical Pharmacology (WCP2018), 18th World Congress of Basic And Clinical Pharmacology. 2018.
Liang Y., Ip M.S.M. and Mak J.C.W., Mito-TEMPO protects cardiomyocytes from cigarette smoke medium-induced inflammation and apoptosis in vitro, 18th World Congress of Basic And Clinical Pharmacology. 2018.
Liang Y., Tian L., Ho K.F., Ip M.S.M. and Mak J.C.W., Mitochondrial Toxicity of Fine Particulate Matter (PM2.5) Collected in Hong Kong in Human Airway Epithelial Cells, 24th Medical Research Conference, Department of Medicine, HKU, Hong Kong Medical Journal. Hong Kong Medical Journal, 2019, 25: 28.
Liang Y., Ip M.S.M. and Mak J.C.W., The Role of Mitochondria in Cigarette Smoke-induced Inflammation and Apoptosis in Cardiomyocytes, 22nd Annual Scientific Meeting of Institute of Cardiovascular Science and Medicine . Hong Kong, Journal of the Hong Kong College of Cardiology, 2018, 26: 108.
Lui M.S.M., Tse H.F., Mak J.C.W., Lam C.L.D., Chan W.S., Chong W.C. and Ip M.S.M., Untreated Obstructive Sleep Apnea Is Associated With Myocardial Injury Independent of Blood Pressure Control in Hypertension, Journal of Clinical Sleep Medicine. 2018, 14: 1841-1847.
Shih K.C., Choy N.K.B., Ho W.L., Shum J.W.H., Lai J.S.M., Huang R., Hui K.M.C. and Ip M.S.M., Incidence of Normal Tension Glaucoma Among Chinese Patients with Treatment Naïve Obstructive Sleep Apnea Syndrome, 2019 Annual Meeting of the Asia Pacific Academy of Ophthalmology. 2019.
WANG Y., Lee Y.K.M., Mak J.C.W. and Ip M.S.M., Low-Frequency Intermittent Hypoxia Suppresses Subcutaneous Adipogenesis and Induces Macrophage Polarization in Lean Mice, Diabetes Metab J. 2019.
Wong S.M., Lam W., Ge M., Yeung S.C., Liang Y., Ip M.S.M. and Mak J.C.W., Cardiac and Pulmonary Inflammatory Responses by Intermittent Hypoxia in C57BL/6N and C57BL/6J Mouse Strains, 24th Medical Research Conference, Department of Medicine, HKU, Hong Kong Medical Journal. 2019, 25: 32.
Xu P., Hui K.M.C., Lui M.S.M., Lam C.L.D., Fong D.Y.T. and Ip M.S.M., Incident Type 2 Diabetes in OSA and Effect of CPAP Treatment, Chest. 2019.
Yeung S.C., Ge M., Mak J.C.W. and Ip M.S.M., Differential effects of intermittent hypoxia on systemic and adipose tissue inflammation in lean and diet-induced obese mice, 24th Medical Research Conference, Department of Medicine, HKU, January 2019. Hong Kong Medical Journal. 2019, 25 (Suppl 1): 45.


Researcher : Ip TP

List of Research Outputs

Chan K.W., Kwong A.S.K., Chan G.C.W., Leung C.P.S., Yiu W.H., Lui S.L., Ip T.P., Cowling B.J., Wong W.L.D., LI B., LI Y., Feng Y., Chan L.Y.Y., Leung J.C.K., Tan K.C.B., Wong C.W.V., Lai K.N. and Tang S.C.W., Best Poster Award, Good Practice In Traditional Chinese Medicine Research Association. 2018.
Chan K.W., Kwong A.S.K., Chan G.C.W., Leung C.P.S., Yiu W.H., Lui S.L., Ip T.P., Cowling B.J., Wong W.L.D., LI B., LI Y., Feng Y., Chan Y.Y., Leung J.C.K., Tan K.C.B., Wong C.W.V., Lai K.N. and Tang S.C.W., Semi-individualised Chinese Medicine Treatment for Diabetic Kidney Disease – From users’ perspectives to SCHEMATIC trial interim result and potential mechanisms, Advances in Integrative Medicine (International Congress on Complementary Medicine Research). 2019, 6: S12.


Researcher : JIAN M

List of Research Outputs

JIAN M., Kwan S.C., Bunting M., Ng C.L. and Chan K.H., Adiponectin suppresses amyloid-beta oligomer (AbO)-induced inflammatory response of microglia via AdipoR1-AMPK-NF-kB signaling pathway, Journal of Neuroinflammation. 2019, 16: 110.
Jian M., Ng C.L. and Chan K.H., Adiponectin attenuates microglia-mediated neuroinflammation and modulates microglia phagocytosis in Alzheimer’s Disease, 14th International Conference on Alzheimer's & Parkinson's Diseases. 2019, Lisbon. 2019.
Ma K.F.O., Ng C.L., Yick L.W., Jian M. and Chan K.H., In vivo electroporation-mediated transfer of interleukin-35 gene decreases demyelination in animal model of multiple sclerosis, 24th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2019, ;25(1)(Supplement 1): 32.
Ng C.L., Jian M., Bunting M., Ma K.F.O., Chung S.K. and Chan K.H., Adiponectin deficiency exacerbated neuropathologenesis and cognitive functions in Alzheimer’s disease mice: potential application of AdipoRon as Alzheimer’s disease treatment, 24th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2019, 25(1)(Supplement 1): 35.
Ng C.L., Jian M., Ma K.F.O. and Chan K.H., Adiponectin deficiency exacerbated vasculo-neuronal dysfunction and degeneration in Alzheimer’s disease mice model, 14th International Conference on Alzheimer's and Parkinson's Disease. 2019, Lisbon. 2019.


Researcher : JIANG Y

List of Research Outputs

Liao S., Zhang Y., Ting S.H.E.R.W.I.N., ZHEN Z., Luo F.A.N., Zhu Z., JIANG Y., SUN S., Lai K.W.H., Lian Q. and Tse H.F., Potent immunomodulation and angiogenic effects of mesenchymal stem cells versus cardiomyocytes derived from pluripotent stem cells for treatment of heart failure, Stem Cell Research & Therapy. 2019, 10.


Researcher : Jian M

List of Research Outputs

JIAN M., Kwan S.C., Bunting M., Ng C.L. and Chan K.H., Adiponectin suppresses amyloid-beta oligomer (AbO)-induced inflammatory response of microglia via AdipoR1-AMPK-NF-kB signaling pathway, Journal of Neuroinflammation. 2019, 16: 110.
Jian M., Ng C.L. and Chan K.H., Adiponectin attenuates microglia-mediated neuroinflammation and modulates microglia phagocytosis in Alzheimer’s Disease, 14th International Conference on Alzheimer's & Parkinson's Diseases. 2019, Lisbon. 2019.
Ma K.F.O., Ng C.L., Yick L.W., Jian M. and Chan K.H., In vivo electroporation-mediated transfer of interleukin-35 gene decreases demyelination in animal model of multiple sclerosis, 24th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2019, ;25(1)(Supplement 1): 32.
Ng C.L., Jian M., Bunting M., Ma K.F.O., Chung S.K. and Chan K.H., Adiponectin deficiency exacerbated neuropathologenesis and cognitive functions in Alzheimer’s disease mice: potential application of AdipoRon as Alzheimer’s disease treatment, 24th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2019, 25(1)(Supplement 1): 35.
Ng C.L., Jian M., Ma K.F.O. and Chan K.H., Adiponectin deficiency exacerbated vasculo-neuronal dysfunction and degeneration in Alzheimer’s disease mice model, 14th International Conference on Alzheimer's and Parkinson's Disease. 2019, Lisbon. 2019.


Researcher : Jin Y

Project Title:Cytogenetic and molecular genetic characterization of esophageal carcinomas
Investigator(s):Jin Y, Kwong YL, Tsao GSW
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:10/2002




Researcher : KWOK HM

List of Research Outputs

Cheung Y.Y., Lee C.H.P., Tang S.M., Xu A., Au K.W., Fong H.Y., Ng K.K., KWOK H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Hai S.H.J.J., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Genetic regulation of Pigment Epithelium-Derived Factor (PEDF): an exome-chip association analysis in Chinese subjects with type 2 diabetes, Diabetes. 2019, 68: 198-206.


Researcher : Kumana CR

List of Research Outputs

Singh G.H.H., Kumana C.R. and Kwong Y.L., Oral Arsenic Trioxide in the Frontline Treatment of Newly-Diagnosed Acute Promyelocytic Leukemia: A 5-Year Prospective Cohort Study, Blood. 2018, 132: 390.
Singh G.H.H., Kumana C.R., Yim R.L.H., Hwang Y.Y.G., Chan S.Y.T., Yip S.F., Lee H.K.K., Mak V., Lau J.S.M., Chan C.C., Kho B., Wong R.S.M., Li W., Lin S.Y., Lau C.K., Ip H.W., Leung R.Y.Y., Lam C.C.K. and Kwong Y.L., Oral arsenic trioxide incorporation into frontline treatment with all‐trans retinoic acid and chemotherapy in newly diagnosed acute promyelocytic leukemia: A 5‐year prospective study, Cancer. 2019.


Researcher : Kung AWC

Project Title:Cost-effective osteoporosis intervention thresholds for Hong Kong Southern Chinese postmenopausal women
Investigator(s):Kung AWC, McGhee S
Department:Medicine
Source(s) of Funding:Health and Health Services Research Fund - Full Grants
Start Date:10/2009


List of Research Outputs

Cheung C.L., Sing C.W., Wong W., Kiel D., Cheung E., Lam J., Cheung T.T., Chan E.W.Y., Kung A.W.C. and Wong I.C.K., Association of Alendronate and Risk of Cardiovascular Events in Patients with Hip Fracture., Annual Meeting of the American-Society-for-Bone-and-Mineral-Research.. 2018.
Cheung C.L., Kung A.W.C. and Tan K.C.B., Serum follicle stimulating hormone is associated with reduced risk of diabetes in postmenopausal women. The Hong Kong osteoporosis study., Maturitas.. 2018, 114: 41-45.
Leung R.Y.H., Cheung B.M.Y., Tan K.C.B., Kung A.W.C. and Cheung C.L., 25-Hydroxyvitamin D and the risk of incident diabetes in Hong Kong Chinese, Public Health Nutrition. 2019, 1-7.
Leung R.Y.H., Li H.Y., Cheung B.M.Y., Tan K.C.B., Kung A.W.C. and Cheung C.L., Serum metabolomic profiling and its association with 25-hydroxyvitamin D, Clinical Nutrition. 2019.
Sing C.W., Wong Y.S., Kiel D.P., Cheung E.Y., Lam K.Y.J., Cheung T.T., Chan E.W., Kung A.W.C., Wong I.C.K. and Cheung C.L., Association of Alendronate and Risk of Cardiovascular Events in Patients With Hip Fracture, Journal of Bone and Mineral Research. 2018, 33: 1422-1434.
Sing C.W., Wong A.Y., Kiel D.P., Cheung E.Y., Lam J.K., Cheung T.T., Chan E.W., Kung A.W.C., Wong I.C.K. and Cheung C.L., Reply to: Association Between Alendronate and All-Cause Mortality and Cardiovascular Mortality Among Hip Fracture: An Alternative Explanation, J Bone Miner Res. 2018, 33(10): 1908-1909.


Researcher : Kung MHW

List of Research Outputs

Ho W.L., Leung C.T.G., Liu H., Pang S.Y.Y., Lam C.S.C., Xian J., Li L., Kung M.H.W., Ramsden D.B. and Ho S.L., Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA), Autophagy. 2019, 1-24.


Researcher : Kwan CM

List of Research Outputs

Chesla C.A., Chun K.M. and Kwan C.M., Overcoming family and cultural challenges for Chinese American patients with diabetes: Provider guidelines, American Diabetes Association’s 79th Scientific Sessions. 2019.


Researcher : Kwan JSK

Project Title:HKU Overseas Fellowship Awards 2016-17
Investigator(s):Kwan JSK
Department:Medicine
Source(s) of Funding:HKU Overseas Fellowship Awards
Start Date:06/2016


Project Title:Effects of regular physical activity on immunosenescence: the role of autophagy and apoptosis on senescent T-lymphocytes and NK cells
Investigator(s):Kwan JSK, Wong GTC, Tse MA, Tipoe GL
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:03/2017


Project Title:Innovative IT Platform To Enable Remote Group Cognitive Stimulation Therapy For Better Cognition And Well-being In Older Dementia Patients And Their Caregivers: The FaceCog Project
Investigator(s):Kwan JSK, Wong GHY, Hsiao JHW, Mak HKF, Lum TYS, Wong GTC
Department:Medicine
Source(s) of Funding:Midstream Research Programme for Universities (MRP)
Start Date:03/2018


List of Research Outputs

CHEN X., Kwan J.S.K., Ma A.C.H. and Chang R.C.C., Inhibition of melanogenesis alters autophagy in zebrafish (Danio rerio), The 14th International Symposium on Healthy Aging. 2019, 57.
CHEN X., Hasan K.M.M., Kwan J.S.K., Ma A.C.H. and Chang R.C.C., Systemic inflammation induces IL-1b-mediated microglia invasion in the Zebrafish brain, The 14th International Symposium on Healthy Aging. 2019, 58.
Choy N.K.B., ZHU M., Pang J.C.S., Chan J.C.H., Ng L.K.A., Fan C.Y., Iu L.P.L., Kwan J.S.K., Lai J.S.M. and Chiu K.C.P., Factors Associated with Poor Eye Drop Administration Technique and the Role of Patient Education among Hong Kong Elderly Population, Journal of Ophthalmology. 2019, 2019: 1-5.
Ho R.T.H., Fong T.C.T., Hon T., Yau C.Y.J., Li B.Y., Chan W.C., Kwan J.S.K., Chiu K.C.P. and Lam L.C.W., Effects of a randomized controlled trial of Dance Movement Therapy on elderly with early dementia, Movement: Brain, Body, Cognition. Harvard, Boston, Harvard Medical School, 2018.
Ho R.T.H., Fong T.C.T., Chan W.C., Kwan J.S.K., Chiu K.C.P., Yau C.Y.J. and Lam L.C.W., Psychophysiological Effects of Dance Movement Therapy and Physical Exercise on Older Adults With Mild Dementia: A Randomized Controlled Trial, The Journals of Gerontology: Series B. 2018.
Wang B., Bao S., ZHANG Z., ZHOU X., WANG J., Fan Y., Zhang Y., Li Y., Chen L.P., Jia Y., LI J., Li M., Zheng W., Mu N., Yang W., Yu Z., Lau D.S.S., Wong S.M., ZHANG Y., Kwan J.S.K., Mak H.K.F., Ambalavanan A., Zhou S., Cai W., Zheng J., Huang S., Rouleau G.A., Yang W., Rogaeva E., Ma X., St George-Hyslop P., Chu L.W. and Song Y., A rare variant in MLKL confers susceptibility to ApoE ɛ4-negative Alzheimer's disease in Hong Kong Chinese population, Neurobiol Aging. 2018, 68:160: e1-e7.


Researcher : Kwan PYL

List of Research Outputs

Yap Y.H.D., Tang S.O.C., Chan G.C.W., Kwan P.Y.L., Ma K.M.M., Mok M.Y. and Chan D.T.M., Longterm Data on Sirolimus Treatment in Patients with Lupus Nephritis, The Journal of Rheumatology. 2018, 45(12): 1663-1670.


Researcher : Kwan SC

List of Research Outputs

JIAN M., Kwan S.C., Bunting M., Ng C.L. and Chan K.H., Adiponectin suppresses amyloid-beta oligomer (AbO)-induced inflammatory response of microglia via AdipoR1-AMPK-NF-kB signaling pathway, Journal of Neuroinflammation. 2019, 16: 110.


Researcher : Kwan SKJ

Project Title:HKU Overseas Fellowship Awards 2016-17
Investigator(s):Kwan JSK
Department:Medicine
Source(s) of Funding:HKU Overseas Fellowship Awards
Start Date:06/2016


Project Title:Effects of regular physical activity on immunosenescence: the role of autophagy and apoptosis on senescent T-lymphocytes and NK cells
Investigator(s):Kwan JSK, Wong GTC, Tse MA, Tipoe GL
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:03/2017


Project Title:Innovative IT Platform To Enable Remote Group Cognitive Stimulation Therapy For Better Cognition And Well-being In Older Dementia Patients And Their Caregivers: The FaceCog Project
Investigator(s):Kwan JSK, Wong GHY, Hsiao JHW, Mak HKF, Lum TYS, Wong GTC
Department:Medicine
Source(s) of Funding:Midstream Research Programme for Universities (MRP)
Start Date:03/2018


List of Research Outputs



Researcher : Kwok HH

List of Research Outputs

Kwok H.H., Lee C.M.N., Deng J., Ip M.S.M. and Lam C.L.D., Lung cancer patient–derived organoid biobank for therapeutic screening, 24th Medical Research Conference, Department of Medicine, HKU, Feb 2019. Hong Kong Medical Journal. 2019, 25 (Suppl.1): 24.
Kwok H.H., NING Z., Chong W.C., Wan T.S.K., Ng M.H.L., Ho G.Y.F., Ip M.S.M. and Lam C.L.D., Transfer of Extracellular Vesicle-Associated-RNAs Induces Drug Resistance in ALK-Translocated Lung Adenocarcinoma, In: Prof. Samuel C. Mok, Cancers. Basel, Switzerland, MDPI, 2019, 11: 104.


Researcher : Kwok WC

List of Research Outputs

Kwok W.C., Ho J.C.M., Lam C.L.D., Lui M.S.M., Ip M.S.M. and Tam C.C.T., Efficacy of gefitinib at reduced dose in EGFR mutant non-small-cell lung carcinoma., 24th Medical Research Conference, Department of Medicine, HKU. Hong Kong Medical Journal. 2019, 25 (Suppl 1): 24.
Kwok W.C., Ho J.C.M., Lam C.L.D., Lui M.S.M., Ip M.S.M. and Tam C.C.T., Progression-free survival among progressed non-small-cell lung cancer with T790M mutation as guided by liquid versus tissue re-biopsy, 24th Medical Research Conference, Department of Medicine, HKU. Hong Kong Medical Journal. 2019, 25 (Suppl 1): 25.
Kwok W.C., Tam C.C.T., Lam C.L.D., Ip M.S.M. and Lui M.S.M., Pulmonary embolism developing after therapeutic drainage of malignant pleural effusions, Respiratory Medicine Case Reports. 2018, 25: 122-123.
Kwok W.C., Liang B.M., Lui M.S.M., Tam C.C.T., Sim P.Y.J., Tse E.W.C., Leung A.Y.H., Kwong Y.L., Lie A.K.W., Ip M.S.M. and Lam C.L.D., Rapid versus gradual lung function decline in bronchiolitis obliterans syndrome after haematopoietic stem cell transplantation is associated with survival outcome, Respirology. 2019, 24: 459-466.


Researcher : Kwong YL

Project Title:Molecular mechanisms and consequences of downregulation of p73 in natural killer cell lymphoma
Investigator(s):Kwong YL
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2002


Project Title:Molecular basis of arsenic resistance in tumours
Investigator(s):Kwong YL, Tse EWC
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2003


Project Title:Provision of free cytogenetic and molecular testing for monitoring of disease relapse after bone marrow transplantation
Investigator(s):Kwong YL, Liang HSR, Lie AKW, Au WY
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:11/2004


Project Title:Provision of ibritumomab for the treatment of lymphoma
Investigator(s):Kwong YL, Liu KY
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:01/2008


Project Title:Provision of oral arsenic trioxide free to patients with cancers
Investigator(s):Kwong YL, Au WY, Chim JCS
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:01/2008


Project Title:Provision of ibritumomab for the treatment of Iymphoma
Investigator(s):Kwong YL, Liu KY
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:05/2010


Project Title:Provision of clofarabine for the treatment of relapsed or refractory acute leukaemia
Investigator(s):Kwong YL, Leung AYH, Tse EWC
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:08/2010


Project Title:Provision of bendamustine for the treatment of non-Hodgkin lymphoma and chronic lymphocytic leukemia
Investigator(s):Kwong YL, Leung AYH, Tse EWC
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:10/2012


Project Title:Provision of free azacitidine for high-risk patient with myelodysplastic syndrome (MDS)
Investigator(s):Kwong YL, Leung AYH
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:01/2014


Project Title:Plasma DNA as a Platform Technology for Cancer Detection
Investigator(s):Kwong YL
Department:Medicine
Source(s) of Funding:Theme-based Research Scheme
Start Date:12/2016


List of Research Outputs

Chim J.C.S., Wong V.K.C., Au Y.L.E. and Kwong Y.L., 3-weekly Daratumumab-IMiD-dexamethasone is highly efficacious, hence financially affordable with enormous economic impacy for relapsed/ refractory Multiple Myeloma in less affluent counties, The 24th Congress of European Haematology Association, Amsterdam, Netherlands. 2019.
Kwok W.C., Liang B.M., Lui M.S.M., Tam C.C.T., Sim P.Y.J., Tse E.W.C., Leung A.Y.H., Kwong Y.L., Lie A.K.W., Ip M.S.M. and Lam C.L.D., Rapid versus gradual lung function decline in bronchiolitis obliterans syndrome after haematopoietic stem cell transplantation is associated with survival outcome, Respirology. 2019, 24: 459-466.
Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Mak L.Y., Wong D.K.H., Fung J.Y.Y., Liu S.H.K., Cheung K.S.M., Lai C.L., Kwong Y.L. and Yuen R.M.F., Monitoring and Treatment of Patients Undergoing Immunotherapy With Anti-CD20 Who are Exposed to HBV, Clinical Gastroenterology and Hepatology. 2018, 17(7): 1410-1412.
Singh G.H.H., Ip H.W., Yim R.L.H., Tang W.F., Pang H.M.H., Lee P., Leung G.M.K., Li J.W.Y., Tang K., So J.C.C., Leung R.Y.Y., Li J., Panagiotou I., Lam C.C.K. and Kwong Y.L., Next-generation sequencing with a 54-gene panel identified unique mutational profile and prognostic markers in Chinese patients with myelofibrosis, Annals of Hematology. 2018.
Singh G.H.H., Kumana C.R. and Kwong Y.L., Oral Arsenic Trioxide in the Frontline Treatment of Newly-Diagnosed Acute Promyelocytic Leukemia: A 5-Year Prospective Cohort Study, Blood. 2018, 132: 390.
Singh G.H.H., Kumana C.R., Yim R.L.H., Hwang Y.Y.G., Chan S.Y.T., Yip S.F., Lee H.K.K., Mak V., Lau J.S.M., Chan C.C., Kho B., Wong R.S.M., Li W., Lin S.Y., Lau C.K., Ip H.W., Leung R.Y.Y., Lam C.C.K. and Kwong Y.L., Oral arsenic trioxide incorporation into frontline treatment with all‐trans retinoic acid and chemotherapy in newly diagnosed acute promyelocytic leukemia: A 5‐year prospective study, Cancer. 2019.


Researcher : LI B

List of Research Outputs

Chan K.W., Kwong A.S.K., Chan G.C.W., Leung C.P.S., Yiu W.H., Lui S.L., Ip T.P., Cowling B.J., Wong W.L.D., LI B., LI Y., Feng Y., Chan L.Y.Y., Leung J.C.K., Tan K.C.B., Wong C.W.V., Lai K.N. and Tang S.C.W., Best Poster Award, Good Practice In Traditional Chinese Medicine Research Association. 2018.
Chan K.W., Kwong A.S.K., Chan G.C.W., Leung C.P.S., Yiu W.H., Lui S.L., Ip T.P., Cowling B.J., Wong W.L.D., LI B., LI Y., Feng Y., Chan Y.Y., Leung J.C.K., Tan K.C.B., Wong C.W.V., Lai K.N. and Tang S.C.W., Semi-individualised Chinese Medicine Treatment for Diabetic Kidney Disease – From users’ perspectives to SCHEMATIC trial interim result and potential mechanisms, Advances in Integrative Medicine (International Congress on Complementary Medicine Research). 2019, 6: S12.
LI B., Leung J.C.K., Chan Y.Y., Yiu W.H., LI Y., LOK W.Y., Liu W.H., Chan K.W., Tse H.F., Lai K.N. and Lai K.N., Amelioration of Endoplasmic Reticulum Stress by Mesenchymal Stem Cells Via Hepatocyte Growth Factor/c‐Met Signaling in Obesity‐Associated Kidney Injury, STEM CELLS Translational Medicine. 2019.
LI B., Leung J.C.K., Chan L.Y., Yiu W.H., Lai K.N. and Tang S.C.W., Mesenchymal Stem Cells Derived from Induced Pluripotent Stem Cells and Bone Marrow Are Equally Effective in Ameliorating Lipotoxicity-Induced Kidney Injury (Conference Abstract)., J Am Soc Nephrol. 2018, 29: 284.


Researcher : LI Y

List of Research Outputs

Chan K.W., Kwong A.S.K., Chan G.C.W., Leung C.P.S., Yiu W.H., Lui S.L., Ip T.P., Cowling B.J., Wong W.L.D., LI B., LI Y., Feng Y., Chan L.Y.Y., Leung J.C.K., Tan K.C.B., Wong C.W.V., Lai K.N. and Tang S.C.W., Best Poster Award, Good Practice In Traditional Chinese Medicine Research Association. 2018.
Chan K.W., Kwong A.S.K., Chan G.C.W., Leung C.P.S., Yiu W.H., Lui S.L., Ip T.P., Cowling B.J., Wong W.L.D., LI B., LI Y., Feng Y., Chan Y.Y., Leung J.C.K., Tan K.C.B., Wong C.W.V., Lai K.N. and Tang S.C.W., Semi-individualised Chinese Medicine Treatment for Diabetic Kidney Disease – From users’ perspectives to SCHEMATIC trial interim result and potential mechanisms, Advances in Integrative Medicine (International Congress on Complementary Medicine Research). 2019, 6: S12.
LI B., Leung J.C.K., Chan Y.Y., Yiu W.H., LI Y., LOK W.Y., Liu W.H., Chan K.W., Tse H.F., Lai K.N. and Lai K.N., Amelioration of Endoplasmic Reticulum Stress by Mesenchymal Stem Cells Via Hepatocyte Growth Factor/c‐Met Signaling in Obesity‐Associated Kidney Injury, STEM CELLS Translational Medicine. 2019.
Yiu W.H., Wong D.W., LOK W.Y., Liu W.H., LI Y., CHAN L.Y., Leung J.C.K., Lan H.Y. and Tang S.C.W., The Long Noncoding RNA Meg3 Mediates TLR4–Induced Renal Inflammation in Experimental Obstructive Nephropathy (Conference Abstracts) , J Am Soc Nephrol . 2018, 29: 953.


Researcher : LI Z

List of Research Outputs

Wong K.Y., YAO Q., Yuan L., LI Z., Ma E.S.K. and Chim J.C.S., Frequent functional activation of RAS signalling not explained by RAS/RAF mutations in relapsed/refractory multiple myeloma, Scientific Reports. 2018, 8.


Researcher : LIU F

List of Research Outputs

LIU F., ZHANG S., Huang F.Y., Wong D.K.H., Mak L.Y., Cheung K.S.M., Lai C.L., Yuen R.M.F. and Seto W.K.W., Characterization of regulatory T cells and the role of PD-1 and TNF-alpha in spontaneous hepatitis B surface antigen seroclearance in chronic hepatitis B, JOURNAL OF HEPATOLOGY. ELSEVIER SCIENCE BV PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, 2019, 70: E454-E455.
LIU F., ZHANG S., Huang F.Y., Wong D.K.H., Mak L.Y., Cheung K.S.M., Lai C.L., Yuen R.M.F. and Seto W.K.W., Characterization of regulatory T cells and the role of PD-1 and TNF-alpha in spontaneous hepatitis B surface antigen seroclearance in chronic hepatitis B, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2019, 701: E454-455.
LIU F., Seto W.K.W., Wong D.K.H., Huang F.Y., Cheung K.S.M., Mak L.Y., Sharma R., ZHANG S., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Plasma fibronectin levels identified via quantitative proteomics profiling predicts hepatitis B surface antigen seroclearance in chronic hepatitis B, The Journal of Infectious Diseases. 2019, 220(6): 940-950.
Liu F., Seto W.K.W., Wong D.K.H., Huang F.Y., Mak L.Y., Cheung K.S.M., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Serum Fibronectin Levels Identified Via Proteomics Profiling Predict Spontaneous Hepatitis B Surface Antigen Seroclearance in Chronic Hepatitis B, HEPATOLOGY. WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2018, 68: 1185A-1186A.
Mak L.Y., Lee C.H.P., Cheung K.S.M., Wong D.K.H., LIU F., Hui R.W., Fung J.Y.Y., Xu A., Lam K.S.L., Yuen R.M.F. and Seto W.K.W., Association of adipokines with hepatic steatosis and fibrosis in chronic hepatitis B patients on long‐term nucleoside analogue, Liver International. 2019, 39(7): 1217-1225.
Mak L.Y., To W.P., Wong D.K.H., Fung J.Y.Y., LIU F., Seto W.K.W., Lai C.L. and Yuen R.M.F., Serum Mac-2 binding protein glycosylation isomer level predicts hepatocellular carcinoma development in E-negative chronic hepatitis B patients, World Journal of Gastroenterology. 2019, 25: 1398-1408.
Seto W.K.W., Liu S.H.K., Mak L.Y., Cheung K.S.M., Wong D.K.H., Liu F., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Treatment Cessation in Chronic Hepatitis B: Predicting Off-Treatment Durability Via Combination of Viral Markers, HEPATOLOGY. WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2018, 68: 248A-249A.
ZHANG S., LIU F., Huang F.Y., Wong D.K.H., Lai C.L., Yuen R.M.F. and Seto W.K.W., The role of Paneth cells in the pathogenesis of non-alcoholic fatty liver disease: A potential gut microbiota-associated mechanism, JOURNAL OF HEPATOLOGY. ELSEVIER SCIENCE BV PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, 2019, 70: E553-E553.


Researcher : LIU Z

List of Research Outputs

LIU Z., JIN L., Yang J.K., Wang B., Wu K.K., Hallenborg P., Xu A. and Cheng K.K., The Dysfunctional MDM2-p53 Axis in Adipocytes Contributes to Ageing Related Metabolic Complications by Induction of Lipodystrophy, Diabetes. 2018, db180684.


Researcher : LO Y

List of Research Outputs

Figueroa-Miranda G., LO Y., Cheung Y.W., Tanner J.A., Offenhausser A. and Mayer D., Improved aptasensor performance for the detection of PfLDH malaria biomarkers in human serum, Aptamers 2019, 6th Oxford Symposium on Aptamers, Oxford University, United Kingdom. 2019.


Researcher : LOK WY

List of Research Outputs

LI B., Leung J.C.K., Chan Y.Y., Yiu W.H., LI Y., LOK W.Y., Liu W.H., Chan K.W., Tse H.F., Lai K.N. and Lai K.N., Amelioration of Endoplasmic Reticulum Stress by Mesenchymal Stem Cells Via Hepatocyte Growth Factor/c‐Met Signaling in Obesity‐Associated Kidney Injury, STEM CELLS Translational Medicine. 2019.
Yiu W.H., Wong D.W., LOK W.Y., Liu W.H., LI Y., CHAN L.Y., Leung J.C.K., Lan H.Y. and Tang S.C.W., The Long Noncoding RNA Meg3 Mediates TLR4–Induced Renal Inflammation in Experimental Obstructive Nephropathy (Conference Abstracts) , J Am Soc Nephrol . 2018, 29: 953.


Researcher : Lai CL

Project Title:A preliminary assessment of safety and antiviral activity of open-label entecavir plus lamivudine therapy in subjects with chronic hepatitis B who have viremia on monotherapy in other entecavir trials
Investigator(s):Lai CL, Yuen RMF
Department:Medicine
Source(s) of Funding:Bristol-Myers-Squibb (HK) - General Award
Start Date:01/2003


Project Title:Long-term assessment of treatment outcomes with entecavir and lamivudine for chronic hepatitis B infection in patients who have enrolled in phase iii entecavir trials
Investigator(s):Lai CL, Yuen RMF
Department:Medicine
Source(s) of Funding:Bristol-Myers-Squibb (HK) - General Award
Start Date:10/2003


Project Title:A randomized, double-blind trial of Telbivudine (LdT) versus Lamivudine in adults with decompensated chronic hepatitis B and evidence of cirrhosis
Investigator(s):Lai CL, Yuen RMF
Department:Medicine
Source(s) of Funding:Idenix Pharmaceuticals, Inc - General Award
Start Date:01/2004


Project Title:Outstanding Researcher Award 2003-2004
Investigator(s):Lai CL
Department:Medicine
Source(s) of Funding:Outstanding Researcher Award
Start Date:07/2004


List of Research Outputs

Fung J.Y.Y., Chok K.S.H., Chan A.C.Y., Dai W.C., She W.H., Sin S.L., Ma K.W., Ng K.C.K., Wong C.L.T., Cheung T.T., Seto W.K.W., Lai C.L., Lo C.M. and Yuen R.M.F., High Predictive value of MELD for short-term mortality in severe acute flares of chronic hepatitis B, Hepatology. 2018, 68: 1211A-1211A.
Fung J.Y.Y., Wong D.K.H., Tanaka Y., Lo C.L.R., Wong C.L.T., Chok K.S.H., Chan A.C.Y., Cheung T.T., Dai W.C., Ng K.C.K., Ng K.T.P., Man K., Ng I.O.L., Seto W.K.W., Lai C.L., Yuen R.M.F. and Lo C.M., Quantitative hepatitis B surface antigen in predicting recurrence of hepatitis B-related hepatocellular carcinoma after liver transplantation, Hepatoma Research. 2018, 4: 62.
Gane E.J., Locarnini S., Lim T.H., Strasser S., Sievert W., Cheng W., Thompson A., Given B., Schluep T., Hamilton J., Li Z., Cloherty G., Wong D.K.H., Schwabe C., Jackson K., Ferrari C., Lai C.L., Gish R.G. and Yuen R.M.F., First results with rna interference (rnai) in chronic hepatitis b (chb) using ARO-HBV. Hepatology 2018; 68(6): 1463A-1463A, Hepatology. 2018, 68(6): 1463A-1463A.
Jadoul M., Berenguer M.C., Doss W., Fabrizi F., Izopet J., Jha V., Kamar N., Kasiske B.L., Lai C.L., Morales J.M., Patel P.R., Pol S., Silva M.O., Balk E.M., Gordon C.E., Earley A., Di M.Y. and Martin P., Executive summary of the 2018 KDIGO Hepatitis C in CKD Guideline: welcoming advances in evaluation and management, Kidney International. 2018, 94: 663-673.
Ko K.L., To W.P., Mak L.Y., Seto W.K.W., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., A Large Cohort Study Examining the Effects of Long-Term Entecavir on Hepatocellular Carcinoma and HBsAg Seroclearance, HEPATOLOGY. WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2018, 68: 260A-260A.
LIU F., ZHANG S., Huang F.Y., Wong D.K.H., Mak L.Y., Cheung K.S.M., Lai C.L., Yuen R.M.F. and Seto W.K.W., Characterization of regulatory T cells and the role of PD-1 and TNF-alpha in spontaneous hepatitis B surface antigen seroclearance in chronic hepatitis B, JOURNAL OF HEPATOLOGY. ELSEVIER SCIENCE BV PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, 2019, 70: E454-E455.
LIU F., ZHANG S., Huang F.Y., Wong D.K.H., Mak L.Y., Cheung K.S.M., Lai C.L., Yuen R.M.F. and Seto W.K.W., Characterization of regulatory T cells and the role of PD-1 and TNF-alpha in spontaneous hepatitis B surface antigen seroclearance in chronic hepatitis B, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2019, 701: E454-455.
LIU F., Seto W.K.W., Wong D.K.H., Huang F.Y., Cheung K.S.M., Mak L.Y., Sharma R., ZHANG S., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Plasma fibronectin levels identified via quantitative proteomics profiling predicts hepatitis B surface antigen seroclearance in chronic hepatitis B, The Journal of Infectious Diseases. 2019, 220(6): 940-950.
Lai C.L., Across borders: The challenge of HBV & HCV with increasing globalization, The Hong Kong Association for the Study of Liver Diseases 31st Annual Scientific Meeting and Intenational Symposium on Hepatology 2018, Hong Kong. 2018.
Lai C.L., Across borders: The challenge of HBV and HCV in the setting of increasing globalization, 2018 International Roche Infectious Diseases (IRIDS 2018), Sepember 24-26, 2018, Vienna, Austria.. 2018.
Lai C.L., Advisor, Gilead Hepatitis Medical Affairs Advisory Program (MAAP), Hong Kong, July 23, 2018. 2018.
Lai C.L., Chair the thematic session: Hepatitis C: Treatment Strategy, Asian Pacific Digestive Week 2017 (APDW 2017), Hong Kong, September 25, 2017. 2018.
Lai C.L., Chronic Hepatitis C in 2018”, Annual Scientific Meeting 2018 - Medical Advances for Community Health, The Federation of Medical Societies of Hong Kong (FMSHK), October 7, 2018, Hong Kong,. 2018.
Lai C.L., Clinical Decisions for CHB Treatment, APASL Single Topic Conference 2018, December 6-8, 2018, Beijing, China.. 2018.
Lai C.L., Co-Moderator, Roundtable 1 - “HCV is curable: What is the best HCV testing algorithm to support HCV elimination programs?, Pre-International Roche Infectious Diseases (IRIDS 2018), Vienna, Austria. 2018.
Lai C.L., Cultivating One’s Self: M, J, MJ, M, Medical Summer Broadening Programme, LKS Faculty of Medicine, The University of Hong Kong, July 23, 2018. 2018.
Lai C.L., Global & Regional Epidemiology of HCV: Pathways to Its Elimination by 2030, Plenary Session 1: Global Perspectives, KDIGO CUHK HCV Implementation Summit (Town Hall Meeting), Prince of Wales Hospital, 1 June 2019, Hong Kong.. 2019.
Lai C.L., Group Member of Opinion Leaders, Planning Meeting of the Hong Kong Organizing Committee for the Hep-Free Asia Summit (Oct 30 - Nov 1, 2019), HKSAR, China. 2019.
Lai C.L., HCV in 2018 EASL Data and Recent Updates, Princess Margaret Hospital Medical Grand Round. 2018.
Lai C.L., HCV in 2018”, EASL Debrief 2018, Queen Elizabeth Hospital, Kowloon, Hong Kong, August 6, 2018. 2018.
Lai C.L., Hepatitis B and C, Seminar on Viral Hepatitis for Nurses and Allied Health Professionals 2019, Special Preventive Programme Viral Hepatitis Control Office, Central for Health Protection, Jun 4, 2019, Hong Kong. 2019.
Lai C.L., Hepatitis and Liver Cancer, Public Health Seminar on World Hepatitis Day 2018, jointly organized by Sai Kung District Council and Hong Kong Hep B Free Foundation, Tseung Kwan O, Hong Kong, July 28, 2018. 2018.
Lai C.L., Hepatitits A-E, Jointly organized by Hep B Free Foundation & the Hong Kong Federation of Women on March 31, 2019, MacPherson Stadium, Kowloon, Hong Kong.. 2019.
Lai C.L., Hepatitits B, Health Talk organized by St Paul’s Convent School, Causeway Bay, Hong Kong, July 10, 2018. 2018.
Lai C.L., Honorary Senior Adviser, Department of Health, HKSAR, Hong Kong (1 Dec 2018-30 Nov 2021).. 2018.
Lai C.L., Introduction of James Gibson Lecture, Symposium II: Genetics & Genomics, HK Pathology Forum 2019, January 26, 2019, Hong Kong.. 2019.
Lai C.L., Life Member, The Royal Australasian College of Physicians. 2018.
Lai C.L., Overview of Chronic Hepatitis B Infection, Hong Kong Sanatorium & Hospital Ltd. Breakfast Meeting, December 11, 2018, Hong Kong,. 2018.
Lai C.L., Overview of Chronic Hepatitis B Infection, Northern District Hospital. 2018.
Lai C.L., Overview of Chronic Hepatitis B Infection, Pamela Youde Nethersole Eastern Hospital, January 21, 2019, Hong Kong.. 2019.
Lai C.L., Overview of Chronic Hepatitis B Infection, Pok Hoi Hospital Medical Meeting, November 30, 2018, Hong Kong.. 2018.
Lai C.L., Overview of Chronic Hepatitis B Infection, Tuen Mun Hospital Medical Meeting, January 11, 2019, Hong Kong. 2019.
Lai C.L., Overview of Chronic hepatitis B Infection, Alice Ho Miu Ling Nethersole Hospital Medical and Healthcare professionals on 24 May 2019, Hong Kong.. 2019.
Lai C.L., Overview of Chronic hepatitis B Infection, Queen Elizabeth Hospital Medical and Healthcare professionals on 21 March 2019, Hong Kong.. 2019.
Lai C.L., Overview of Chronic hepatitis B Infection, Tseung Kwan O Hospital Medical and Healthcare professionals on 29 May 2019, Hong Kong.. 2019.
Lai C.L., Patients with Chronic Hepatitis B (CHB) on Immunosuppression, Baptitis Hospital, October 25, 2018, Hong Kong.. 2018.
Lai C.L., Patients with Chronic Hepatitis B (CHB) on Immunosuppression, Chronic Hepatitis B Round Table Meeting with Oncologists, Hong Kong Integrated Oncology Centre, Hong Kong, August 14, 2018. 2018.
Lai C.L., Patients with Chronic Hepatitis B (CHB) on Immunosuppression, Joint Annual Scientific Meeting 2018 of the Hong Kong College of Dermatologists and the Hong Kong Society of Paediatric Dermatology, November 4, 2018, Hong Kong.. 2018.
Lai C.L., Reducing the risks when treating patients with Chronic Hepatitis B, Round Table Discussion under the Auspices of Gastroenterological Society of Singapore and supported by an educational grant from Gilead Sciences, 6 June 2019, Singapore.. 2019.
Lai C.L., Should Antenatal Antiviral Medication be Given for Hepatitis B Carriers?, The Obstetrical and Gynaecological Society of Hong Kong Annual Scientific Meeting 2019, Hong Kong Academy of Medicine Jockey Club Building, 1-2 June 2019, Hong Kong.. 2019.
Lai C.L., Two Patients with Cirrhosis of the Liver, Macau Society of Clinical Internal Medicine, January 27, 2019, Macau. 2019.
Lai C.L., Updates on HCV management, Scientific Dinner Symposium of Macao Society of Gastroenterology and Hepatology (MSGEH), Macau, August 29, 2018. 2018.
Lai C.L., Updates on Hepatitis C Infection, The 10th Macau Forum of Hospital Medicine, and 2018 Annual Scientific Meeting of Macau Physician Association of Public Hospital, October 7, 2018, Macau.. 2018.
Lai C.L., Work Group Member, KDIGO 2018 Clinical Practice Guideline for the Prevention, Diagnosis, Evaluation, and Treatment of Hepatitis C in Chronic Kidney Disease. 2018.
Liu F., Seto W.K.W., Wong D.K.H., Huang F.Y., Mak L.Y., Cheung K.S.M., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Serum Fibronectin Levels Identified Via Proteomics Profiling Predict Spontaneous Hepatitis B Surface Antigen Seroclearance in Chronic Hepatitis B, HEPATOLOGY. WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2018, 68: 1185A-1186A.
Liu S.H.K., Seto W.K.W., Lau E.H.Y., Wong D.K.H., Lam Y.F., Cheung K.S.M., Mak L.Y., Ko K.L., To W.P., Law M.W.K., Wu J.T.K., Lai C.L. and Yuen R.M.F., A territory-wide prevalence study on blood-borne and enteric viral hepatitis in Hong Kong, The Journal of Infectious Diseases. 2019, 219(12): 1924-1933.
Ma H.C.J., Mak L.Y., Cheung K.S.M., Fung J.Y.Y., Lai C.L., Yuen R.M.F. and Seto W.K.W., Concomitant diabetes mellitus increases risk of liver fibrosis in treatment-naive chronic hepatitis B with low viral loads: Results from a matched case-control study, JOURNAL OF HEPATOLOGY. ELSEVIER SCIENCE BV PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, 2019, 70: E264-E264.
Mak L.Y., Wong D.K.H., Seto W.K.W., Ning Q., Cheung K.S.M., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Correlation of serum Mac-2-binding protein glycosylation isomer (M2BPGi) and liver stiffness in chronic hepatitis B infection, Hepatology International. 2019, 13(2): 148-156.
Mak L.Y., Seto W.K.W., Hui R.W., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Fibrosis evolution in chronic hepatitis B E‐antigen negative patients across a 10‐year interval, Journal of Viral Hepatitis. 2019, 26(7): 818-827.
Mak L.Y., Wong D.K.H., Seto W.K.W., Cheung K.S.M., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., High Serum Mac-2-binding protein glycosylation isomer (M2BPGi) level was associated with incident hepatocellular carcinoma in entecavir-treated chronic hepatitis B patients, Hepatology. 2018, 68: 864A-864A.
Mak L.Y., To W.P., Wong D.K.H., Fung J.Y.Y., LIU F., Seto W.K.W., Lai C.L. and Yuen R.M.F., Serum Mac-2 binding protein glycosylation isomer level predicts hepatocellular carcinoma development in E-negative chronic hepatitis B patients, World Journal of Gastroenterology. 2019, 25: 1398-1408.
Mak L.Y., Ko M., To E., Wong D.K.H., Ma J.H.C., Hui T.L.Y., Seto W.K.W., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Serum Mac-2-binding protein glycosylation isomer and risk of hepatocellular carcinoma in entecavir-treated chronic hepatitis B patients, Journal of Gastroenterology and Hepatology. 2019.
Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Mak L.Y., Wong D.K.H., Fung J.Y.Y., Liu S.H.K., Cheung K.S.M., Lai C.L., Kwong Y.L. and Yuen R.M.F., Monitoring and Treatment of Patients Undergoing Immunotherapy With Anti-CD20 Who are Exposed to HBV, Clinical Gastroenterology and Hepatology. 2018, 17(7): 1410-1412.
Seto W.K.W., Liu S.H.K., Mak L.Y., Cheung K.S.M., Wong D.K.H., Liu F., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Treatment Cessation in Chronic Hepatitis B: Predicting Off-Treatment Durability Via Combination of Viral Markers, HEPATOLOGY. WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2018, 68: 248A-249A.
Wong D.K.H., Cheng C.Y.S., Mak L.Y., To W.P., Lo C.L.R., Cheung T.T., Seto W.K.W., Fung J.Y.Y., Man K., Lai C.L. and Yuen R.M.F., Among Patients with Undetectable Hepatitis B Surface Antigen and Hepatocellular Carcinoma, a High Proportion Has Integration of HBV DNA into Hepatocyte DNA and No Cirrhosis, Clinical Gastroenterology and Hepatology. 2019.
Wong D.K.H., Cheng C.Y.S., Mak L.Y., To W.P., Cheung T.T., Seto W.K.W., Fung J.Y.Y., Man K., Lai C.L. and Yuen R.M.F., High Rate of HBV DNA Integration in Hepatocellular Carcinoma Patients with Occult Hepatitis B Infection, HEPATOLOGY. WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2018, 68: 331A-331A.
Wong D.K.H., Cheng C.Y.S., Mak L.Y., To W.P., Cheung T.T., Seto W.K.W., Fung J.Y.Y., Man K., Lai C.L. and Yuen R.M.F., Integration of HBV DNA near cancer-related genes in HBsAg-negative hepatocellular carcinoma patients, JOURNAL OF HEPATOLOGY. ELSEVIER SCIENCE BV PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, 2019, 70: E269-E269.
Wong D.K.H., Cheng C.Y.S., Mak L.Y., To W.P., Cheung T.T., Seto W.K.W., Fung J.Y.Y., Man K., Lai C.L. and Yuen R.M.F., Integration of HBV DNA near cancer-related genes in HBsAg-negative hepatocellular carcinoma patients, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2019, 701: E269.
YounossI Z.M., Stepanova M., Henry L., Han H.H., Ahn S.H., Lim Y.S., Chuang W.L., Kao J.H., Nuguyen K.V., Lai C.L., Chan H.L.Y. and Lai W., Sofosbuvir and ledipasvir are associated with high sustained virologic response and improvement of health-related quality of life in East Asian patients with hepatitis C virus infection, Journal of Viral Hepatitis. 2018.
Younossi Z.M., Stepanova M., Henry L., Han K.H., Ahn S.H., Lim Y.S., Chuang W.L., Kao J.H., Kinh N., Lai C.L., Yuen R.M.F., Chan H.L.Y. and Lai W., The effect of interferon-free regimens on health-related quality of life in East Asian patients with chronic hepatitis C, Liver International. 2018, 38: 1179-1187.
Yuen R.M.F., Locarnini S., Lim T.H., Strasser S., Sievert W., Cheng W., Thompson A., Given B., Schluep T., Hamilton J., Cloherty G., Wong D.K.H., Schwabe C., Jackson K., Ferrari C., Lai C.L., Gish R.G. and Gane E., Short term RNA interference therapy in chronic hepatitis B using JNJ-3989 brings majority of patients to HBsAg < 100 IU/ml threshold, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2019, 701: E51-52.
ZHANG S., LIU F., Huang F.Y., Wong D.K.H., Lai C.L., Yuen R.M.F. and Seto W.K.W., The role of Paneth cells in the pathogenesis of non-alcoholic fatty liver disease: A potential gut microbiota-associated mechanism, JOURNAL OF HEPATOLOGY. ELSEVIER SCIENCE BV PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, 2019, 70: E553-E553.


Researcher : Lai KN

Project Title:The role of the renin-angiotensin system in the tubulointerstitial injury of IgA nephropathy (IgAN)
Investigator(s):Lai KN, Leung JCK
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:02/2004


List of Research Outputs

Chan K.W., Kwong A.S.K., Chan G.C.W., Leung C.P.S., Yiu W.H., Lui S.L., Ip T.P., Cowling B.J., Wong W.L.D., LI B., LI Y., Feng Y., Chan L.Y.Y., Leung J.C.K., Tan K.C.B., Wong C.W.V., Lai K.N. and Tang S.C.W., Best Poster Award, Good Practice In Traditional Chinese Medicine Research Association. 2018.
Chan K.W., Kwong A.S.K., Chan G.C.W., Leung C.P.S., Yiu W.H., Lui S.L., Ip T.P., Cowling B.J., Wong W.L.D., LI B., LI Y., Feng Y., Chan Y.Y., Leung J.C.K., Tan K.C.B., Wong C.W.V., Lai K.N. and Tang S.C.W., Semi-individualised Chinese Medicine Treatment for Diabetic Kidney Disease – From users’ perspectives to SCHEMATIC trial interim result and potential mechanisms, Advances in Integrative Medicine (International Congress on Complementary Medicine Research). 2019, 6: S12.
LI B., Leung J.C.K., Chan Y.Y., Yiu W.H., LI Y., LOK W.Y., Liu W.H., Chan K.W., Tse H.F., Lai K.N. and Lai K.N., Amelioration of Endoplasmic Reticulum Stress by Mesenchymal Stem Cells Via Hepatocyte Growth Factor/c‐Met Signaling in Obesity‐Associated Kidney Injury, STEM CELLS Translational Medicine. 2019.
LI B., Leung J.C.K., Chan L.Y., Yiu W.H., Lai K.N. and Tang S.C.W., Mesenchymal Stem Cells Derived from Induced Pluripotent Stem Cells and Bone Marrow Are Equally Effective in Ameliorating Lipotoxicity-Induced Kidney Injury (Conference Abstract)., J Am Soc Nephrol. 2018, 29: 284.
Leung J.C.K., Lai K.N. and Tang S.C.W., Role of Mesangial-Podocytic-Tubular Cross-Talk in IgA Nephropathy, Seminars in Nephrology. 2018, 38: 485-495.


Researcher : Lai KWH

List of Research Outputs

Chan Y.H., Ngai M.C., Chen Y., Wu M., YU Y., ZHEN Z., Lai K.W.H., Cheung T.T., Ho L.M., Chung H.Y., Lau W.C.S., Tse H.F. and Yiu K.H., Cumulative Rheumatic Inflammation Modulates the Bone–Vascular Axis and Risk of Coronary Calcification, Journal of the American Heart Association. 2019, 8.
Chan Y.H., Ngai M.C., Chen Y., Wu M., YU Y., ZHEN Z., Lai K.W.H., Cheung T.T., Ho L.M., Chung H.Y., Lau W.C.S., Lau C.P., Tse H.F. and Yiu K.H., Osteogenic circulating endothelial progenitor cells are linked to electrocardiographic conduction abnormalities in rheumatic patients, Annals of Noninvasive Electrocardiology. 2019, e12651.
Liao S., Zhang Y., Ting S.H.E.R.W.I.N., ZHEN Z., Luo F.A.N., Zhu Z., JIANG Y., SUN S., Lai K.W.H., Lian Q. and Tse H.F., Potent immunomodulation and angiogenic effects of mesenchymal stem cells versus cardiomyocytes derived from pluripotent stem cells for treatment of heart failure, Stem Cell Research & Therapy. 2019, 10.
Ng K.M., Lau V.Y.M., Vidhu D., Cai Z., Lee Y.K., Lai K.W.H., Tse H.F. and Siu D.C.W., Empagliflozin Ammeliorates High Glucose Induced-Cardiac Dysfuntion in Human iPSC-Derived Cardiomyocytes, Scientific Reports. 2018, 8.


Researcher : Lam CCS

List of Research Outputs

Huang D., Cheng Y., Wong Y.T.A., Yung S.A., Tam C.C., Chan K.W.K., Lam C.C.S., Yiu K.H., Hai S.H.J.J., Lau C.P., Chan E.W.Y., Chiang C.E., Wong K.L., Cheung T.T., Cheung B.M.Y., Feng Y.Q., Tam N., Chen J.Y., Yue W.S., Hu H.X., Chen L., Tse H.F., Chan P.H.M. and Siu D.C.W., Thrombolysis in myocardial infarction risk score for secondary prevention of recurrent cardiovascular events in a real-world cohort of post-acute myocardial infarction patients, Circulation. 2019, 83(4): 809-817.


Researcher : Lam CL

Project Title:The role of nicotinic acetylcholine receptor (nAChR) in bronchial epithelium in relation to lung carcinogenesis
Investigator(s):Lam CLD, Ip MSM, Tsao GSW, Lam WK
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:06/2010


Project Title:Therapeutic target gene mutation analysis for newly established lung cancer cell lines from local Chinese patients
Investigator(s):Lam CLD
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:05/2011


Project Title:Prospective Evaluation of Selection Criteria for Lung Cancer Screening with Low-dose Thoracic Computed Tomography and Standardized System for Nodule Management - An International Study
Investigator(s):Lam CLD, Lui MSM, Tam CCT, Lam CLK
Department:Medicine
Source(s) of Funding:The Terry Fox Foundation
Start Date:08/2017


Project Title:Testing for Plasma EGFR Mutations in Advanced Stage Non-small Cell Lung Cancer
Investigator(s):Lam CLD
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:04/2018


List of Research Outputs



Researcher : Lam CLD

Project Title:The role of nicotinic acetylcholine receptor (nAChR) in bronchial epithelium in relation to lung carcinogenesis
Investigator(s):Lam CLD, Ip MSM, Tsao GSW, Lam WK
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:06/2010


Project Title:Therapeutic target gene mutation analysis for newly established lung cancer cell lines from local Chinese patients
Investigator(s):Lam CLD
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:05/2011


Project Title:Prospective Evaluation of Selection Criteria for Lung Cancer Screening with Low-dose Thoracic Computed Tomography and Standardized System for Nodule Management - An International Study
Investigator(s):Lam CLD, Lui MSM, Tam CCT, Lam CLK
Department:Medicine
Source(s) of Funding:The Terry Fox Foundation
Start Date:08/2017


Project Title:Testing for Plasma EGFR Mutations in Advanced Stage Non-small Cell Lung Cancer
Investigator(s):Lam CLD
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:04/2018


List of Research Outputs

Hsin M.K.Y. and Lam C.L.D., Does the lung nodule look aggressive enough to warrant a more extensive operation?, The Journal of Thoracic and Cardiovascular Surgery. 2018, 156: 1667-1668.
Kwok H.H., Lee C.M.N., Deng J., Ip M.S.M. and Lam C.L.D., Lung cancer patient–derived organoid biobank for therapeutic screening, 24th Medical Research Conference, Department of Medicine, HKU, Feb 2019. Hong Kong Medical Journal. 2019, 25 (Suppl.1): 24.
Kwok H.H., NING Z., Chong W.C., Wan T.S.K., Ng M.H.L., Ho G.Y.F., Ip M.S.M. and Lam C.L.D., Transfer of Extracellular Vesicle-Associated-RNAs Induces Drug Resistance in ALK-Translocated Lung Adenocarcinoma, In: Prof. Samuel C. Mok, Cancers. Basel, Switzerland, MDPI, 2019, 11: 104.
Kwok W.C., Ho J.C.M., Lam C.L.D., Lui M.S.M., Ip M.S.M. and Tam C.C.T., Efficacy of gefitinib at reduced dose in EGFR mutant non-small-cell lung carcinoma., 24th Medical Research Conference, Department of Medicine, HKU. Hong Kong Medical Journal. 2019, 25 (Suppl 1): 24.
Kwok W.C., Tam T.C.C. and Lam C.L.D., First reported case of afatinib-associated toxic megacolon, Respirology Case Reports. 2018, 6: e00360.
Kwok W.C., Ho J.C.M., Lam C.L.D., Lui M.S.M., Ip M.S.M. and Tam C.C.T., Progression-free survival among progressed non-small-cell lung cancer with T790M mutation as guided by liquid versus tissue re-biopsy, 24th Medical Research Conference, Department of Medicine, HKU. Hong Kong Medical Journal. 2019, 25 (Suppl 1): 25.
Kwok W.C., Tam C.C.T., Lam C.L.D., Ip M.S.M. and Lui M.S.M., Pulmonary embolism developing after therapeutic drainage of malignant pleural effusions, Respiratory Medicine Case Reports. 2018, 25: 122-123.
Kwok W.C., Liang B.M., Lui M.S.M., Tam C.C.T., Sim P.Y.J., Tse E.W.C., Leung A.Y.H., Kwong Y.L., Lie A.K.W., Ip M.S.M. and Lam C.L.D., Rapid versus gradual lung function decline in bronchiolitis obliterans syndrome after haematopoietic stem cell transplantation is associated with survival outcome, Respirology. 2019, 24: 459-466.
Lam C.L.D., Associate Editor, Respirology Case Reports. 2018.
Lam C.L.D., Basic and clinical research in lung cancer, Invited visiting lecture, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, 28, Nov, 2019.. 2018.
Lam C.L.D., Basic and clinical research in lung cancer, Invited visiting lecture, Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan, 28, Nov, 2019.. 2018.
Lam C.L.D., Circulating biomarkers in lung cancer, International Symposium on Respiratory Diseases Lung Cancer Summit, 16 Nov, 2018, Xiamen, China.. 2018.
Lam C.L.D., Management of Malignant Pleural Effusion, HKTS / CHEST Delegation Hong Kong and Macau Autumn Respiratory Seminar 2018 cum Symposium and Hands-on Workshop on Pleural Diseases, 17 – 18 November 2018.. 2018.
Lam C.L.D., Precision medicine in lung cancer, 2. International Symposium on Respiratory Diseases Lung Cancer Summit, 16 Nov, 2018, Xiamen, China.. 2018.
Lam C.L.D. and Ip M.S.M., Sleep apnoea and immune regulation: The story is only beginning, Respirology. 2019, 24: 624-625.
Lam C.L.D., Thoracic USG: Pleural diseases., HKTS / CHEST Delegation Hong Kong and Macau Autumn Respiratory Seminar 2018 cum Symposium and Hands-on Workshop on Pleural Diseases, 17 – 18 November 2018.. 2018.
Lui M.S.M., Tse H.F., Mak J.C.W., Lam C.L.D., Chan W.S., Chong W.C. and Ip M.S.M., Untreated Obstructive Sleep Apnea Is Associated With Myocardial Injury Independent of Blood Pressure Control in Hypertension, Journal of Clinical Sleep Medicine. 2018, 14: 1841-1847.
Muruganandan S., Azzopardi M., Fitzgerald D.B., Shrestha R., Kwan B.C.H., Lam C.L.D., De Chaneet C.C., Rashid Ali M.R.S., Yap E., Tobin C.L., Garske L.A., Nguyen P.T., Stanley C., Popowicz N.D., Kosky C., Thomas R.A.J.E.S.H., Read C.A., Budgeon C.A., Feller-Kopman D., Maskell N.A., Murray K. and Lee Y.C.G., Aggressive versus symptom-guided drainage of malignant pleural effusion via indwelling pleural catheters (AMPLE-2): an open-label randomised trial, The Lancet Respiratory Medicine. 2018.
Xu P., Hui K.M.C., Lui M.S.M., Lam C.L.D., Fong D.Y.T. and Ip M.S.M., Incident Type 2 Diabetes in OSA and Effect of CPAP Treatment, Chest. 2019.


Researcher : Lam CLK

Project Title:Evaluation Study on Quality of Care of Healthcare Programmes
Investigator(s):Lam CLK, Lam TP, Chin WY, Chen JY, Lam TP
Department:Med - Family Medicine Unit
Source(s) of Funding:Hospital Authority - General Award
Start Date:04/2010


Project Title:Epidemiological Study on Different Body Constitution for the "Treatment of Not Yet ill " Programme.
Investigator(s):Lam CLK, Wong W
Department:Med - Family Medicine Unit
Source(s) of Funding:Hospital Authority - General Award
Start Date:04/2010


Project Title:Provision of Data Analysis and Report Writing Services for Conducting the Population Health Survey 2014/15
Investigator(s):Lam CLK, Cheung BMY, Yu YTE, Wong CKH, Guo Y
Department:Family Med & Primary Care
Source(s) of Funding:Department of Health - General Award
Start Date:07/2016


Project Title:10-year risk prediction models of complications and mortality of diabetes mellitus in Chinese patients in primary care in Hong Kong
Investigator(s):Lam CLK, Fong DYT, Tan KCB, Fung SCC, Wan YFE
Department:Family Med & Primary Care
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:07/2017


Project Title:22nd WONCA World Conference 2018 Seoul; Workshop "Professional Training & Development in Family Medicine/GP Around the World- What is New?
Investigator(s):Lam CLK
Department:Family Med & Primary Care
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2018
Completion Date:10/2018


List of Research Outputs

Li S.M., Fong D.Y.T., Wong J.Y.H., Wilkinson K., Shapiro C., Choi P.H., McPherson D.B., Lam C.L.K. and Ip M.S.M., Nonrestorative sleep scale: reliable and valid for the Chinese population, Quality of Life Research. 2019, 28: 1685-1692.


Researcher : Lam CSC

List of Research Outputs

Ho W.L., Leung C.T.G., Liu H., Pang S.Y.Y., Lam C.S.C., Xian J., Li L., Kung M.H.W., Ramsden D.B. and Ho S.L., Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA), Autophagy. 2019, 1-24.


Researcher : Lam KSL

Project Title:The Endocrine Society's 88th Annual Meeting Adipocyte Fatty Acid Binding Protein as a Potential Circulating Metabolic Hormone: Clinical and Functional Studies
Investigator(s):Lam KSL
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2006


Project Title:Ageing
Investigator(s):Lam KSL, Xu A, Lum TYS
Department:Medicine
Source(s) of Funding:Seed Funding for Strategic Research Theme
Start Date:09/2013


Project Title:Establishing a Phase 1 Clinical Trials Centre in Queen Mary Hospital: Extending Hong Kong's Competitive Edges in Healthcare, Education and Life Sciences Research and Development
Investigator(s):Lam KSL, Lau YL, Cheung BMY, Lam CW, Yau HKC
Department:Medicine
Source(s) of Funding:Commissioned Programme on Phase 1 Clinical Trials Centre
Start Date:02/2014
Completion Date:10/2019


Project Title:ENDO 2019; MicroRNA 34a-mediated FGF21 resistance in the adipose tissue contributes to insulin resistance and hypoadiponectinemia in diet-induced obesity
Investigator(s):Lam KSL
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:03/2019
Completion Date:03/2019


Project Title:Enhancing early phase clinical trials on novel pharmaceutical products in Hong Kong
Investigator(s):Lam KSL, Lau YL, Cheung BMY, Yau HKC
Department:Medicine
Source(s) of Funding:Commissioned Research Programmes - Early Phase Clinical Trials on Novel Pharmaceutical Products
Start Date:05/2019


List of Research Outputs

Cheung B.M.Y. and Lam K.S.L., Never too old for statin treatment?, The Lancet. 2019, 393: 379-380.
Cheung T.T., Chiu W.Y.J., Yuen R.M.F., Lam K.S.L., Cheung B.M.Y., Feng H.P., Yeh W.W., Wang J.D., Li W.T., Zhao X.M., Wang Z.Q. and Mu S.M., A Phase I, Single- and Multiple-dose Study to Evaluate the Pharmacokinetics of Elbasvir and Grazoprevir in Healthy Chinese Participants” [Clinical Therapeutics 40 (2018) 719–732], Clinical Therapeutics. 2018, 40: 719-732.
Cheung Y.Y., Lee C.H.P., Tang S.M., Xu A., Au K.W., Fong H.Y., Ng K.K., KWOK H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Hai S.H.J.J., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Genetic regulation of Pigment Epithelium-Derived Factor (PEDF): an exome-chip association analysis in Chinese subjects with type 2 diabetes, Diabetes. 2019, 68: 198-206.
Lam K.S.L., Associate Editor, Chinese Journal of Diabetes. 2018.
Lam K.S.L., Associate Editor, Journal of Diabetes Investigation. 2019.
Lam K.S.L., Editor Board Member, The Journal of Clinical Endocrinology Society. 2019.
Lam K.S.L., Editorial Board Member, Journal of Diabetes Investigation. 2018.
Lam K.S.L., Editorial Board Member, Journal of the Endocrine Society. 2018.
Lam K.S.L., FGF21 mediates the inter-talk between major metabolic regulators, Asian and Oceanian Physiological Societies Congress (FAOPS) 2019. Kobe, Japan. 2019.
Lam K.S.L., FGF21: a multifarious regulator of glucose metabolism. (Plenary Lecture), Asia Islet Biology & Incretin Symposium (AIBIS), Seoul, 2-4 Aug 2018. 2018.
Lam K.S.L., FGF21: a multifarious regulator of glucose metabolism, Asia Islet Biology & Incretin Symposium (AIBIS), Seoul. 2018.
Lee C.H.P., Woo Y.C., Lam K.S.L. and Tan K.C.B., Case series of Chinese patients with dysthyroid optic neuropathy: a single centre audit, 5th International Thyroid Eye Disease Symposium, Singapore, Feb 2019.
Lee C.H.P., Cheung Y.Y., Woo Y.C., Lui D.T.W., Yuen M.A.M., Fong H.Y., Chow W.S., Xu A. and Lam K.S.L., Circulating Adipocyte Fatty Acid–Binding Protein Concentrations Predict Multiple Mortality Outcomes among Men and Women with Diabetes, Clinical Chemistry. 2018, clinchem.2018.289157.
Lee C.H.P., Chan R.S.M., Wan Y., Woo Y.C., Cheung Y.Y., Fong H.Y., Cheung B.M.Y., Lam T.H., Janus E., Woo J. and Lam K.S.L., Dietary Intake of Anti-Oxidant Vitamins A, C, and E Is Inversely Associated with Adverse Cardiovascular Outcomes in Chinese—A 22-Years Population-Based Prospective Study, Nutrients. 2018, 10: 1664.
Lee C.H.P., Woo Y.C. and Lam K.S.L., Fighting the Health Challenges of Diabetes in Hong Kong: A Window Into Mainland China, American Journal of Public Health. 2018, 108: 1623-1624.
Lee C.H.P., Cheung Y.Y., Woo Y.C., Lui D.T.W., Yuen M.A.M., Fong H.Y., Chow W.S., Xu A. and Lam K.S.L., Prospective associations of circulating adipocyte fatty acid-binding protein levels with risks of renal outcomes and mortality in type 2 diabetes, Diabetologia. 2019, 62: 169-177.
Lee C.H.P., Woo Y.C., Lam K.Y.J., Lee C.H.A., Lam K.S.L. and Tan K.C.B., The effects of insulin treatment on circulating ketone levels in patients with type 2 diabetes on sodium-glucose co-transporter 2 inhibitors, American Diabetes Association 79th Scientific Sessions, San Francisco, June 2019.
Lui D.T.W., Woo Y.C., Chow W.S., Lee C.H.P., Lee C.H.A., Leung E.K.H., Tan K.C.B., Lam K.S.L. and Lam K.Y.J., Glycogenic hepatopathy as an unusual etiology of deranged liver function in a patient with type 1 diabetes, Medicine. 2019, 98: e15296.
Mak L.Y., Lee C.H.P., Cheung K.S.M., Wong D.K.H., LIU F., Hui R.W., Fung J.Y.Y., Xu A., Lam K.S.L., Yuen R.M.F. and Seto W.K.W., Association of adipokines with hepatic steatosis and fibrosis in chronic hepatitis B patients on long‐term nucleoside analogue, Liver International. 2019, 39(7): 1217-1225.
Pan Y., Hui X., Hoo R.L.C., Ye D., Chan C.Y.C., Feng T., Wang Y., Lam K.S.L. and Xu A., Adipocyte-secreted Exosomal Microrna-34a Inhibits M2 Macrophage Polarization To Promote Obesity-induced Adipose Inflammation, Journal of Clinical Investigation. 2019, 129: 834-849.
Shu L., WU X., CHEONG L.Y., Zhou Z., Hoo R.L.C., Lam K.S.L. and Xu A., FABP4 mediates autoimmune destruction of beta cells by enhancing the crosstalk between innate and adaptive immunity/ Oral presentation, Asia Islet Biology and Incretin Symposium (AIBIS 2018). 2018.
Tang S.M., Cheung Y.Y., Lam K.S.L. and Sham P.C., Faculty of Medicine research output prize (2018-2019) - Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants, LKS Faculty of Medicine, HKU. 2019.
Wang B., Lin H., Li X., Lam K.S.L., Xu A. and Cheng K., APPL2 deficiency suppresses glucose-stimulated insulin secretion by disrupting F-actin remodeling in pancreatic β cells, 2018 Asia Islet Biology & Incretin Symposium. 2018.
Wong H.Y.Q., Li R.H.W., Lam K.S.L., Tam S., Shek C.C., Lee V.C.Y., Yeung W.S.B., Ho P.C. and Ng E.H.Y., Independent association of serum vitamin D with anti-Mullerian hormone levels in women with polycystic ovary syndrome, Clinical Endocrinology. 2018.
Wong Y.K., Cheung Y.Y., Tang S.M., Au K.W., Hai S.H.J.J., Lee C.H.P., Lau G.K.K., Cheung B.M.Y., Sham P.C., Xu A., Lam K.S.L. and Tse H.F., Age-Biomarkers-Clinical Risk Factors for Prediction of Cardiovascular Events in Patients With Coronary Artery Disease., Arterioscler Thromb Vasc Biol. American Heart Association, Inc., 2018, 38: 2519-2527.


Researcher : Lam KYI

List of Research Outputs

CHOW J.X., Lam K.Y.I., Wong Y.Y.S., Lau W.C.S. and Chan V.S.F., Dysregulation of AIM2 inflammasome response in patients with Systemic Lupus Erythematosus, 13th World Immune Regulation Meeting. 2019.


Researcher : Lam KYJ

List of Research Outputs

Lee C.H.P., Woo Y.C., Lam K.Y.J., Lee C.H.A., Lam K.S.L. and Tan K.C.B., The effects of insulin treatment on circulating ketone levels in patients with type 2 diabetes on sodium-glucose co-transporter 2 inhibitors, American Diabetes Association 79th Scientific Sessions, San Francisco, June 2019.
Lui D.T.W., Woo Y.C., Chow W.S., Lee C.H.P., Lee C.H.A., Leung E.K.H., Tan K.C.B., Lam K.S.L. and Lam K.Y.J., Glycogenic hepatopathy as an unusual etiology of deranged liver function in a patient with type 1 diabetes, Medicine. 2019, 98: e15296.
Sing C.W., Wong Y.S., Kiel D.P., Cheung E.Y., Lam K.Y.J., Cheung T.T., Chan E.W., Kung A.W.C., Wong I.C.K. and Cheung C.L., Association of Alendronate and Risk of Cardiovascular Events in Patients With Hip Fracture, Journal of Bone and Mineral Research. 2018, 33: 1422-1434.


Researcher : Lam MF

List of Research Outputs

Shea Y.F., Lee M.C., Mok M.Y., Lam M.F., Chu L.W., Chan H.W.F. and Chan D.T.M., Self-Care Peritoneal Dialysis Patients with Cognitive Impairment Have a Higher Risk of Peritonitis in the Second Year, Peritoneal Dialysis International. 2019, 39(1): 51-58.


Researcher : Lam SK

Project Title:Biotech Company in the Faculty of Medicine, The University of Hong Kong
Investigator(s):Lam SK
Department:Medicine
Source(s) of Funding:The University of Hong Kong Foundation Seed Grant
Start Date:07/2003


Project Title:Treatment of gastrointestinal cancer by targeting survivin using adeno-associated virus gene delivery system
Investigator(s):Lam SK, Wong CYB, Lin MC
Department:LKS Medical Faculty
Source(s) of Funding:General Research Fund (GRF)
Start Date:09/2004




Researcher : Lam SK

Project Title:In Vitro and in vivo combination of arginase and chemotherapeutic drugs in squamous cell lung carcinoma
Investigator(s):Lam SK, Ho JCM
Department:Medicine
Source(s) of Funding:The Hong Kong Anti-Cancer Society (HKACS) - General Award
Start Date:03/2016


Project Title:Targeting polyamine for prevention and therapy in malignant pleural mesohelioma
Investigator(s):Lam SK, Ho JCM
Department:Medicine
Source(s) of Funding:Pneumoconiosis Compensation Fund Board - General Award
Start Date:12/2016


List of Research Outputs

Lam S.K., Yan S., XU S., U K.P., Cheng P.N. and Ho J.C.M., Endogenous arginase 2 as a potential biomarker for PEGylated arginase 1 treatment in xenograft models of squamous cell lung carcinoma , Oncogenesis. 2019, 8: 18.
Lam S.K., U K.P., Li Y.V., XU S., Cheng P.N. and Ho J.C.M., Inhibition of ornithine decarboxylase 1 facilitates pegylated arginase treatment in lung adenocarcinoma xenograft models, Oncology Reports. 2018.
Lam S.K., Yan S., XU S. and Ho J.C.M., Targeting polyamines as potential adjuvant therapy in malignant pleural mesothelioma xenograft models, IASLC 19th World Conference on Lung Cancer. 2018.
Lam S.K., Yan S., XU S. and Ho J.C.M., Targeting polyamines as potential adjuvant therapy in malignant pleural mesothelioma xenograft models, 24th Medical Research Conference. Medical Journal, 2019, 25: 26.
XU S., Lam S.K., Cheng P.N. and Ho J.C.M., Recombinant human arginase induces apoptosis via oxidative stress and cell cycle arrest in small cell lung cancer, Cancer Science. 2018, Epub ahead of print.


Researcher : Lam YF

List of Research Outputs

Lam Y.F., Seto W.K.W., Tong S.M., Cheung K.S.M., Lo O.S.H., Hung F.N.I., Law W.L. and Leung W.K., Rates of metachronous adenoma after curative resection for left-sided or right-sided colon cancer, Intestinal Research. 2018, 16: 619-627.
Liu S.H.K., Seto W.K.W., Lau E.H.Y., Wong D.K.H., Lam Y.F., Cheung K.S.M., Mak L.Y., Ko K.L., To W.P., Law M.W.K., Wu J.T.K., Lai C.L. and Yuen R.M.F., A territory-wide prevalence study on blood-borne and enteric viral hepatitis in Hong Kong, The Journal of Infectious Diseases. 2019, 219(12): 1924-1933.


Researcher : Lam YM

List of Research Outputs

CHEN Y., Au T.W.K., Chan D., Sit K.Y., Zhen Z., Ho K.L., Wong D., Ho L.M., Yap Y.H.D., Lam Y.M., Lau C.P., Tse H.F., Chan D.T.M. and Yiu K.H., Clinical Benefit of Valvular Surgery in Patients with Chronic Kidney Disease, International Heart Journal. 2018, 59: 759-765.
CHEN Y., Liu Y., Seto W.K.W., Wu M., YU Y., Lam Y.M., Au W.K., Chan D., Sit K.Y., Ho L.M., Tse H.F. and Yiu K.H., Prognostic Value of Hepatorenal Function By Modified Model for End‐stage Liver Disease (MELD) Score in Patients Undergoing Tricuspid Annuloplasty, Journal of the American Heart Association. 2018, 7: e009020.
Chen Y., Au T.W.K., Chan D., Sit K.Y., Zhen Z., Ho K.L., Wong D., Ho L.M., Yap Y.H.D., Lam Y.M., Lau C.P., Tse H.F., Chan D.T.M. and Yiu K.H., Clinical Benefit of Valvular Surgery in Patients with Chronic Kidney Disease. , International heart journal. 2018, 59(4): 759-765.
Chen Y., Liu Y., Seto W.K.W., Wu M., YU Y., Lam Y.M., Au T.W.K., Sit K.Y., Ho L.M., Tse H.F. and Yiu K.H., Prognostic Value of Hepatorenal Function By Modified Model for End-stage Liver Disease (MELD) Score in Patients Undergoing Tricuspid Annuloplasty, Journal of the American Heart Association. 2018, 7(14): 1-11.
Chen Y., Liu Y., Wu M., Lam Y.M., Ho L.M., Lau C.P., Au T.W.K., Tse H.F. and Yiu K.H., Prognostic value of tricuspid valve geometry and leaflet coaptation status in patients undergoing tricuspid annuloplasty: a three-dimensional echocardiography study, PCR Tokyo Valves 2019.
Wu M., Chen Y., Au T.W.K., Chan D., Sit K.Y., Ho K.L., Ho L.M., Lam Y.M., Lau C.P., Chan D.T.M., Tse H.F. and Yiu K.H., Predictive value of acute kidney injury for major adverse cardiovascular events following tricuspid annuloplasty: A comparison of three consensus criteria, Journal of Cardiology. 2018, 72: 247-254.


Researcher : Lan HY

Project Title:Essential role of SMAD3 in cardiac repair and fibrosis
Investigator(s):Lan HY
Department:Medicine
Source(s) of Funding:Sun Chieh Yeh Heart Foundation - General Award
Start Date:08/2006


Project Title:Role of Smad signalling in the pathogenesis of hypertensive nephropathy and a novel therapeutic potential using ultrasound-microbubble-mediated transfer of inducible Smad7
Investigator(s):Lan HY
Department:Medicine
Source(s) of Funding:Baxter Health Care Ltd. - General Award
Start Date:05/2008


Project Title:Gene therapy for diabetic nephropathy using ultrasound-microbubble-mediated transfer of inducible smad7
Investigator(s):Lan HY
Department:Medicine
Source(s) of Funding:Pharmaceutical Industry - General Award
Start Date:05/2008




Researcher : Lan XR

Project Title:Mechanisms of Peritoneal Fibrosis: Role of TGF-beta Signaling
Investigator(s):Lan XR, Lan HY, Leung JCK
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:09/2008




Researcher : Lau CP

Project Title:Evaluation of the antianginal efficacy and safety of oral chronic administration of ivabradine (5mg b.i.d. then 7.5mg b.i.d or 10mg b.i.d) compared to atenolol (50mg o.d then 100mg o.d), in patients with stable effort angina pectorals
Investigator(s):Lau CP, Lee KLF
Department:Medicine
Source(s) of Funding:Other Funding Scheme
Start Date:05/2000


Project Title:Roles of macrophage migration inhibitory factor (MIF) in acute myocardial infarction
Investigator(s):Lau CP, Yu CM, Lan HY
Department:Medicine
Source(s) of Funding:Low Budget High Impact Programme
Start Date:11/2000


List of Research Outputs

CHEN Y., Au T.W.K., Chan D., Sit K.Y., Zhen Z., Ho K.L., Wong D., Ho L.M., Yap Y.H.D., Lam Y.M., Lau C.P., Tse H.F., Chan D.T.M. and Yiu K.H., Clinical Benefit of Valvular Surgery in Patients with Chronic Kidney Disease, International Heart Journal. 2018, 59: 759-765.
Chan Y.H., Ngai M.C., Chen Y., Wu M., YU Y., ZHEN Z., Lai K.W.H., Cheung T.T., Ho L.M., Chung H.Y., Lau W.C.S., Lau C.P., Tse H.F. and Yiu K.H., Osteogenic circulating endothelial progenitor cells are linked to electrocardiographic conduction abnormalities in rheumatic patients, Annals of Noninvasive Electrocardiology. 2019, e12651.
Chen Y., Au T.W.K., Chan D., Sit K.Y., Zhen Z., Ho K.L., Wong D., Ho L.M., Yap Y.H.D., Lam Y.M., Lau C.P., Tse H.F., Chan D.T.M. and Yiu K.H., Clinical Benefit of Valvular Surgery in Patients with Chronic Kidney Disease. , International heart journal. 2018, 59(4): 759-765.
Chen Y., Liu Y., Wu M., Lam Y.M., Ho L.M., Lau C.P., Au T.W.K., Tse H.F. and Yiu K.H., Prognostic value of tricuspid valve geometry and leaflet coaptation status in patients undergoing tricuspid annuloplasty: a three-dimensional echocardiography study, PCR Tokyo Valves 2019.
Hai S.H.J.J., Fang J., Tam C.C., Wong C.K., Un C.K., Siu D.C.W., Lau C.P. and Tse H.F., Safety and feasibility of a midseptal implantation technique of a leadless pacemaker, Heart Rhythm. 2019, 16: 896-902.
Huang D., Cheng Y., Wong Y.T.A., Yung S.A., Tam C.C., Chan K.W.K., Lam C.C.S., Yiu K.H., Hai S.H.J.J., Lau C.P., Chan E.W.Y., Chiang C.E., Wong K.L., Cheung T.T., Cheung B.M.Y., Feng Y.Q., Tam N., Chen J.Y., Yue W.S., Hu H.X., Chen L., Tse H.F., Chan P.H.M. and Siu D.C.W., Thrombolysis in myocardial infarction risk score for secondary prevention of recurrent cardiovascular events in a real-world cohort of post-acute myocardial infarction patients, Circulation. 2019, 83(4): 809-817.
Lau C.P., Hai S.H.J.J. and Siu D.C.W., Implantable cardioverter defibrillators in Asian population, Pacing and Clinical Electrophysiology. 2018, 41: 1627-1629.
Perera K.S., Sharma M., Connolly S.J., Wang J., Gold M.R., Hohnloser S.H., Lau C.P., Van Gelder I.C., Morillo C., Capucci A., Israel C.W., Botto G. and Healey J.S., Stroke type and severity in patients with subclinical atrial fibrillation: An analysis from the Asymptomatic Atrial Fibrillation and Stroke Evaluation in Pacemaker Patients and the Atrial Fibrillation Reduction Atrial Pacing Trial (ASSERT), American Heart Journal. 2018, 201: 160-163.
Wu M., Chen Y., Au T.W.K., Chan D., Sit K.Y., Ho K.L., Ho L.M., Lam Y.M., Lau C.P., Chan D.T.M., Tse H.F. and Yiu K.H., Predictive value of acute kidney injury for major adverse cardiovascular events following tricuspid annuloplasty: A comparison of three consensus criteria, Journal of Cardiology. 2018, 72: 247-254.


Researcher : Lau G

Project Title:Prevalence and Natural History of Non-Alcoholic Fatty Liver Diseases in Hong Kong Chinese
Investigator(s):Lau G
Department:Medicine
Source(s) of Funding:Hong Kong Liver Foundation - General Award
Start Date:02/2005


Project Title:Basic science study on the disease mechanism, clinical surveillance and outcomes of severe hepatitis B infection
Investigator(s):Lau G
Department:Medicine
Source(s) of Funding:Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:12/2007




Researcher : Lau GKK

Project Title:Prevalence and Natural History of Non-Alcoholic Fatty Liver Diseases in Hong Kong Chinese
Investigator(s):Lau G
Department:Medicine
Source(s) of Funding:Hong Kong Liver Foundation - General Award
Start Date:02/2005


Project Title:Basic science study on the disease mechanism, clinical surveillance and outcomes of severe hepatitis B infection
Investigator(s):Lau G
Department:Medicine
Source(s) of Funding:Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:12/2007




Researcher : Lau GKK

List of Research Outputs

CHEN S., XU X., Lau G.K.K., Li L.S.W., WONG Y.K., Yau C., Mak H.K.F., Chan Q., Chang H.C.C. and Hui S.K., The association between functional brain network and functional outcome after acute ischemic stroke, The 26th Annual Meeting of the International Society for Magnetic Resonance in Medicine. 2019, 3895.
Cheng Y.M., Tang Y.M.J., Lum T.Y.S., Lau G.K.K., Fong K., Fu Y. and Lou V.W., Empower Family Functioning for Stroke Caregivers: A Two-Tier Care Management Model, International Federation on Ageing, 14th Global Conference on Ageing. 2018.
Cheung S.S.L., Lau G.K.K., Chan K.H., Wong Y.H.I., Lai J.S.M., Tang W.K. and Shih K.C., Optic neuritis as the initial clinical presentation of limbic encephalitis: a case report, Journal of Medical Case Reports. 2018.
Lau G.K.K., Lau C.D., Chan D.T.M. and Tang S.C.W., 1962 Albert Lasker Basic Medical Resaerch Award – Choh Hao Li (Ch. 12)., Nobel and Lasker Laureates of Chinese Descent in Literature and Science, Edited by Todd S. Ing, Keith K. Lau, Joseph M. Chan, Hon-lok Tang and Angela T. Hadsell and Laurence K. Chan,. World Scientific, Singapore, 2019, 183-199.
Lau G.K.K. and Rothwell P.M., Acute Treatment of Major Stroke: General Principles, In: Gary K. K. Lau, Sarah T. Pendlebury, Peter M. Rothwell, Transient Ischemic Attack and Stroke: Diagnosis, Investigation and Treatment. Cambridge University Press, 2018, 296-306.
Lau G.K.K. and Rothwell P.M., Acute Treatment of Transient Ischemic Attack and Minor Stroke, In: Gary K. K. Lau, Sarah T. Pendlebury, Peter M. Rothwell, Transient Ischemic Attack and Stroke: Diagnosis, Investigation and Treatment. Cambridge University Press, 2018, 282-295.
Lau G.K.K., Pego P., Mazzucco S., Li L., Howard D.P.J., Kuker W. and Rothwell P.M., Age and sex-specific associations of carotid pulsatility with small vessel disease burden in transient ischemic attack and ischemic stroke, International Journal of Stroke. 2018, 174749301878444.
Lau G.K.K., Tsang C.O.A., Teo K.C., Li H.L., Chu L.K.W., Li J.C.H., Chan M.K.C., Wan V.H.L., Hui S.K. and Mak H.K.F., Age-Specific Associations of Renal Impairment and Cerebral Small Vessel Disease Burden in Chinese with Ischaemic Stroke, Journal of Stroke and Cerebrovascular Diseases. 2019, 28: 1274-1280.
Lau G.K.K. and Rothwell P.M., Anatomy and Physiology, In: Gary K. K. Lau, Sarah T. Pendlebury, Peter M. Rothwell, Transient Ischemic Attack and Stroke: Diagnosis, Investigation and Treatment. Cambridge University Press, 2018, 52-64.
Lau G.K.K. and Rothwell P.M., Brain Imaging in Major Acute Stroke, In: Gary K. K. Lau, Sarah T. Pendlebury, Peter M. Rothwell, Transient Ischemic Attack and Stroke: Diagnosis, Investigation and Treatment. Cambridge University Press, 2018, 176-190.
Lau G.K.K. and Rothwell P.M., Brain Imaging in Transient Ischemic Attack and Minor Stroke, In: Gary K. K. Lau, Sarah T. Pendlebury, Peter M. Rothwell, Transient Ischemic Attack and Stroke: Diagnosis, Investigation and Treatment. Cambridge University Press, 2018, 159-175.
Lau G.K.K. and Rothwell P.M., Carotid Endarterectomy, In: Gary K. K. Lau, Sarah T. Pendlebury, Peter M. Rothwell, Transient Ischemic Attack and Stroke: Diagnosis, Investigation and Treatment. Cambridge University Press, 2018, 373-387.
Lau G.K.K. and Rothwell P.M., Carotid Stenting and Other Interventions, In: Gary K. K. Lau, Sarah T. Pendlebury, Peter M. Rothwell, Transient Ischemic Attack and Stroke: Diagnosis, Investigation and Treatment. Cambridge University Press, 2018, 388-398.
Lau G.K.K. and Rothwell P.M., Causes of Spontaneous Intracranial Hemorrhage, In: Gary K. K. Lau, Sarah T. Pendlebury, Peter M. Rothwell, Transient Ischemic Attack and Stroke: Diagnosis, Investigation and Treatment. Cambridge University Press, 2018, 113-126.
Lau G.K.K. and Rothwell P.M., Causes of Transient Ischemic Attack and Ischemic Stroke, In: Gary K. K. Lau, Sarah T. Pendlebury, Peter M. Rothwell, Transient Ischemic Attack and Stroke: Diagnosis, Investigation and Treatment. Cambridge University Press, 2018, 71-112.
Lau G.K.K. and Rothwell P.M., Cerebral Venous Thrombosis, In: Gary K. K. Lau, Sarah T. Pendlebury, Peter M. Rothwell, Transient Ischemic Attack and Stroke: Diagnosis, Investigation and Treatment. Cambridge University Press, 2018, 429-437.
Lau G.K.K., Cerebral small vessel disease, HK-Beijing-Taiyuan Medical Forum . 2018.
Lau G.K.K., Distinguished Research Paper Award for Young Investigators , Hong Kong College of Physicians. 2018.
Lau G.K.K. and Rothwell P.M., Epidemiology, In: Gary K. K. Lau, Sarah T. Pendlebury, Peter M. Rothwell, Transient Ischemic Attack and Stroke: Diagnosis, Investigation and Treatment. Cambridge University Press, 2018, 1-16.
Lau G.K.K. and Rothwell P.M., Genetics, In: Gary K. K. Lau, Sarah T. Pendlebury, Peter M. Rothwell, Transient Ischemic Attack and Stroke: Diagnosis, Investigation and Treatment. Cambridge University Press, 2018, 35-51.
Lau G.K.K. and Rothwell P.M., Intervention for Asymptomatic Carotid Stenosis, In: Gary K. K. Lau, Sarah T. Pendlebury, Peter M. Rothwell, Transient Ischemic Attack and Stroke: Diagnosis, Investigation and Treatment. Cambridge University Press, 2018, 419-428.
Lau G.K.K., Long-Term Premorbid Blood Pressure and Cerebral Small Vessel Disease Burden on Imaging in Transient Ischemic Attack and Ischemic Stroke, Stroke. 2018, 49: 2053-2060.
Lau G.K.K. and Rothwell P.M., Long-Term Prognosis after Transient Ischemic Attack and Stroke, In: Gary K. K. Lau, Sarah T. Pendlebury, Peter M. Rothwell, Transient Ischemic Attack and Stroke: Diagnosis, Investigation and Treatment. Cambridge University Press, 2018, 253-264.
Lau G.K.K. and Rothwell P.M., Medical Therapies, In: Gary K. K. Lau, Sarah T. Pendlebury, Peter M. Rothwell, Transient Ischemic Attack and Stroke: Diagnosis, Investigation and Treatment. Cambridge University Press, 2018, 357-372.
Lau G.K.K. and Rothwell P.M., Methods of Determining Prognosis, In: Gary K. K. Lau, Sarah T. Pendlebury, Peter M. Rothwell, Transient Ischemic Attack and Stroke: Diagnosis, Investigation and Treatment. Cambridge University Press, 2018, 213-230.
Lau G.K.K. and Rothwell P.M., Non-Radiological Investigations for Transient Ischemic Attack and Stroke, In: Gary K. K. Lau, Sarah T. Pendlebury, Peter M. Rothwell, Transient Ischemic Attack and Stroke: Diagnosis, Investigation and Treatment. Cambridge University Press, 2018, 207-212.
Lau G.K.K. and Rothwell P.M., Pathophysiology of Acute Cerebral Ischemia, In: Gary K. K. Lau, Sarah T. Pendlebury, Peter M. Rothwell, Transient Ischemic Attack and Stroke: Diagnosis, Investigation and Treatment. Cambridge University Press, 2018, 65-70.
Lau G.K.K. and Rothwell P.M., Recovery and Rehabilitation after Stroke, In: Gary K. K. Lau, Sarah T. Pendlebury, Peter M. Rothwell, Transient Ischemic Attack and Stroke: Diagnosis, Investigation and Treatment. Cambridge University Press, 2018, 339-356.
Lau G.K.K., Response by Lau and Rothwell to Letter Regarding Article, “Antiplatelet Treatment After Transient Ischemic Attack and Ischemic Stroke in Patients With Cerebral Microbleeds in 2 Large Cohorts and an Updated Systematic Review”, Stroke. 2018, 49.
Lau G.K.K. and Rothwell P.M., Risk Factors, In: Gary K. K. Lau, Sarah T. Pendlebury, Peter M. Rothwell, Transient Ischemic Attack and Stroke: Diagnosis, Investigation and Treatment. Cambridge University Press, 2018, 17-34.
Lau G.K.K. and Rothwell P.M., Selection of Patients for Carotid Intervention, In: Gary K. K. Lau, Sarah T. Pendlebury, Peter M. Rothwell, Transient Ischemic Attack and Stroke: Diagnosis, Investigation and Treatment. Cambridge University Press, 2018, 399-418.
Lau G.K.K. and Rothwell P.M., Short-Term Prognosis after Major Stroke, In: Gary K. K. Lau, Sarah T. Pendlebury, Peter M. Rothwell, Transient Ischemic Attack and Stroke: Diagnosis, Investigation and Treatment. Cambridge University Press, 2018, 246-252.
Lau G.K.K. and Rothwell P.M., Short-Term Prognosis after Transient Ischemic Attack and Minor Stroke, In: Gary K. K. Lau, Sarah T. Pendlebury, Peter M. Rothwell, Transient Ischemic Attack and Stroke: Diagnosis, Investigation and Treatment. Cambridge University Press, 2018, 231-245.
Lau G.K.K. and Rothwell P.M., Specific Treatment of Acute Intracerebral Hemorrhage, In: Gary K. K. Lau, Sarah T. Pendlebury, Peter M. Rothwell, Transient Ischemic Attack and Stroke: Diagnosis, Investigation and Treatment. Cambridge University Press, 2018, 328-338.
Lau G.K.K. and Rothwell P.M., Specific Treatments for Major Acute Ischemic Stroke, In: Gary K. K. Lau, Sarah T. Pendlebury, Peter M. Rothwell, Transient Ischemic Attack and Stroke: Diagnosis, Investigation and Treatment. Cambridge University Press, 2018, 307-327.
Lau G.K.K. and Rothwell P.M., Spontaneous Subarachnoid Hemorrhage, In: Gary K. K. Lau, Sarah T. Pendlebury, Peter M. Rothwell, Transient Ischemic Attack and Stroke: Diagnosis, Investigation and Treatment. Cambridge University Press, 2018, 438-455.
Lau G.K.K. and Rothwell P.M., The Clinical Features and Differential Diagnosis of Acute Stroke, In: Gary K. K. Lau, Sarah T. Pendlebury, Peter M. Rothwell, Transient Ischemic Attack and Stroke: Diagnosis, Investigation and Treatment. Cambridge University Press, 2018, 139-158.
Lau G.K.K., Pendlebury S.T. and Rothwell P.M., Transient Ischemic Attack and Stroke: Diagnosis, Investigation and Treatment. Cambridge University Press, 2018.
Lau G.K.K. and Rothwell P.M., Vascular Imaging in Transient Ischemic Attack and Stroke, In: Gary K. K. Lau, Sarah T. Pendlebury, Peter M. Rothwell, Transient Ischemic Attack and Stroke: Diagnosis, Investigation and Treatment. Cambridge University Press, 2018, 191-206.
Lou V.W., Tang Y.M.J., Lum T.Y.S., Lau G.K.K., Fong K., Cheng Y.M. and Fu Y., Effectiveness of a family-based care management model for strok caregivers: a randomized control trail, Innovation in Aging. 2018, 2: 292-292.
Lou V.W., Tang Y.M.J., Lum T.Y.S., Lau G.K.K., Fung K., Cheng Y.M., Fu Y. and Ko W.T., Enhancing family functioning for stroke caregivers using a two-tier care management mode, 15th World Congress on Long Term Care in Chinese Communities. 2018.
Tsang C.O.A., Cheung I.H.W., Lau G.K.K., Brinjikji W., Kallmes D. and Krings T., Outcomes of stent retriever versus aspiration-first thrombectomy in ischaemic stroke: a systematic review and metaanalysis, American Journal of Neuroradiology . 2018, 39(11): 2070-2076.
Wong Y.K., Cheung Y.Y., Tang S.M., Au K.W., Hai S.H.J.J., Lee C.H.P., Lau G.K.K., Cheung B.M.Y., Sham P.C., Xu A., Lam K.S.L. and Tse H.F., Age-Biomarkers-Clinical Risk Factors for Prediction of Cardiovascular Events in Patients With Coronary Artery Disease., Arterioscler Thromb Vasc Biol. American Heart Association, Inc., 2018, 38: 2519-2527.


Researcher : Lau KK

List of Research Outputs

Tsang C.O.A., Cheung I.H.W., Lau K.K., Brinjikji W., Kallmes D.F. and Krings T., Outcomes of stent retriever versus aspiration-first thrombectomy in ischemic stroke: a systematic review and meta-analysis, American Journal of Neuroradiology. 2018, 39(11): 2070-2076.
Tsang C.O.A., Lau K.K., Tsang C.P., Tse M.Y.M., Lee R. and Lui W.M., Severity of intracranial carotid artery calcification in intracranial atherosclerosis-related occlusion treated with endovascular thrombectomy, Clinical Neurology and Neurosurgery. 2018, 174: 214-216.
Tsang C.O.A., Orru E., Klostranec J.M., Yang I.H., Lau K.K., Tsang C.P., Lui W.M., Pereira V.M. and Krings T., Thrombectomy outcomes of intracranial atherosclerosis-related occlusions, Stroke. 2019, Epub on 2019-05-14.


Researcher : Lau VYM

List of Research Outputs

Ng K.M., Lau V.Y.M., Vidhu D., Cai Z., Lee Y.K., Lai K.W.H., Tse H.F. and Siu D.C.W., Empagliflozin Ammeliorates High Glucose Induced-Cardiac Dysfuntion in Human iPSC-Derived Cardiomyocytes, Scientific Reports. 2018, 8.


Researcher : Lau WCS

Project Title:Prospective study of the clinical pattern of systemic lupus erythematosus in Hong Kong
Investigator(s):Lau WCS
Department:Medicine
Source(s) of Funding:Other Funding Scheme
Start Date:01/1993


Project Title:Effects of sex hormones on lymphocyte function in systemic lupus erythematosus
Investigator(s):Lau WCS, Mok MYT
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2002


Project Title:A study to evaluate the immunopathology of Severe Acute Respiratory Syndrome
Investigator(s):Lau WCS, Chan YTE, Cheung BMY
Department:Medicine
Source(s) of Funding:VCO SARS Research Fund
Start Date:07/2003


Project Title:Evaluation of the effects of sex hormones on neutrophils and macrophage apoptosis and macrophage phagocytic clearance of apoptotic neutrophils in systemic lupus erythematosus
Investigator(s):Lau WCS
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2003


Project Title:Dendritic cell function and their effects on B cell activation in systemic lupus erythematosus
Investigator(s):Lau WCS
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:12/2005


Project Title:Interactions between plasmacytoid dendritic cells and T regulatory / interleukin-17 producing T-helper cells in systemic lupus erythematosus
Investigator(s):Lau WCS
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:04/2012


Project Title:The role of plasmacytoid dendritic cells in systemic lupus erythematosus
Investigator(s):Lau WCS, Chan VSF
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:06/2013


Project Title:Advances in Immunology in Health and Disease
Investigator(s):Lau WCS
Department:Medicine
Source(s) of Funding:Croucher Summer Courses
Start Date:07/2014


Project Title:Validation of a new definition of lupus low disease activity state (LLDAS): Clinical and management implications
Investigator(s):Lau WCS
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:04/2015


Project Title:Centre for Research into Circulating Fetal Nucleic Acids
Investigator(s):Lau WCS
Department:Medicine
Source(s) of Funding:Theme-based Research Scheme
Start Date:01/2016


Project Title:Dysregulation of interleukin-18 receptor accessory protein in neutrophils of lupus nephritis patients – a pilot study
Investigator(s):Lau WCS, Chan VSF
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Mini Grant
Start Date:06/2019


List of Research Outputs

CHOW J.X., Lam K.Y.I., Wong Y.Y.S., Lau W.C.S. and Chan V.S.F., Dysregulation of AIM2 inflammasome response in patients with Systemic Lupus Erythematosus, 13th World Immune Regulation Meeting. 2019.
Chan Y.H., Ngai M.C., Chen Y., Wu M., YU Y., ZHEN Z., Lai K.W.H., Cheung T.T., Ho L.M., Chung H.Y., Lau W.C.S., Tse H.F. and Yiu K.H., Cumulative Rheumatic Inflammation Modulates the Bone–Vascular Axis and Risk of Coronary Calcification, Journal of the American Heart Association. 2019, 8.
Chan Y.H., Ngai M.C., Chen Y., Wu M., YU Y., ZHEN Z., Lai K.W.H., Cheung T.T., Ho L.M., Chung H.Y., Lau W.C.S., Lau C.P., Tse H.F. and Yiu K.H., Osteogenic circulating endothelial progenitor cells are linked to electrocardiographic conduction abnormalities in rheumatic patients, Annals of Noninvasive Electrocardiology. 2019, e12651.
Chen J.Y., Wu Y.H., Wright A., Leung G.K.K., Tsang J.P.Y. and Lau W.C.S., What ethical dilemmas in clinical clerkships cause moral distress in medical students?, Transform MedEd 2018.
Cheung T.T., TSOI M.F., Cheung B.M.Y. and Lau W.C.S., Mortality and causes of death in inflammatory arthritis patients in Hong Kong 1997-2016, 24th Medical Research Conference. Hong Kong, Hong Kong Medical Journal, 2019, 25 (1), supp 1: 13.
Chung H.Y. and Lau W.C.S., Apparent Diffusion Coefficient as an Imaging Biomarker for Spinal Disease Activity in Axial Spondyloarthritis, Radiology. 2019, 180960.
Chung H.Y., Lau W.C.S., Tsang H.L.H., Chan C.W.S., Li P.H., Lee K.H. and Wong P.Y.S., Diffusion-weighted imaging versus short tau inversion recovery sequence: Usefulness in detection of active sacroiliitis and early diagnosis of axial spondyloarthritis, PLoS one. 2018.
Kandane‐Rathnayake R., Golder V., Louthrenoo W., Luo S.F., Jand Wu Y.J., Li Z., An Y., Lateef A., Sockalingam S., Navarra S.V., Zamora L., Hamijoyo L., Katsumata Y., Harigai M., Chan M., O’Neill S., Goldblatt F., Hao Y., Zhang Z., Al‐Saleh J., Khamashta M., Takeuchi T., Tanaka Y., Bae S.C., Lau W.C.S., Hoi A., Nikpour M. and Morand E.F., Development of the Asia Pacific Lupus Collaboration cohort, International Journal of Rheumatic Diseases. 2019, 22: 425-433.
Lam T.P., Sun K.S.T., Chan H.Y., Lau W.C.S., Lam K.F. and Sanson-Fisher R., Perceptions of Chinese Towards Dementia in Hong Kong—Diagnosis, Symptoms and Impacts, International Journal of Environmental Research and Public Health. 2019, 16: 128.
Lau W.C.S., Chia F., Dans L., Harrison A., Hsieh T.Y., Jain R., Jung S.M., Kishimoto M., Kumar A., Leong K.P., Li Z., Lichauco J.J., Louthrenoo W., Luo S.F., Mu R., Nash P., Ng C.T., Suryana B., Wijaya L.K. and Yeap S.S., 2018 update of the APLAR recommendations for treatment of rheumatoid arthritis, International Journal of Rheumatic Diseases. 2019, 22: 357-375.
Lau W.C.S., APLAR Spondyloarthritis Treatment Recommendations., SpA Forum and Workshop. HKU-SZN Hospital, Shenzhen, 21 September, 2018. 2018.
Lau W.C.S., APLAR update on rheumatoid arthritis treatment., 10th International Forum on Rheumatoid Arthritis, Beijing, September 2018. 2018.
Lau W.C.S., Application to leadership in the East Asian Context., Executive Leadership Course, Leading Change in Health Professional Education in Vietnam, Da Lat, Vietnam, 15-16 January, 2019. 2019.
Lau W.C.S., Case illustration in how to create and sustain a culture of innovation, creativity and diversity., Executive Leadership Course, Leading Change in Health Professional Education in Vietnam, Da Lat, Vietnam, 15-16 January, 2019. 2019.
Lau W.C.S., Disruptions in Medicine: Impact on Specialist Training., Hong Kong Hospital Authority Convention 2019, Hong Kong Convention & Exhibition Centre, 14-15 May 2019. 2019.
Lau W.C.S., Disruptions in medicine: what are the impacts?, The Society of Physicians of HK Annual Scientific Meeting, Langhan Hotel, 4 Nov 2018. 2018.
Lau W.C.S., IgG4 related disease case series: Experience in Hong Kong., 20th Asia Pacific League of Associations for Rheumatology, Kaohsiung, 8 September 2018. 2018.
Lau W.C.S., IgG4 – it’s everywhere!, Philippine Rheumatology Association (PRA) Annual Meeting 2019, SMX Convention Center, Lanang, Davao City, Philippines, 7-9 March 2019. 2019.
Lau W.C.S., Improving outcomes of lupus related recurrent abortion., 6th World Congress on Controversies, Debates & Consensus in Bone, Muscle & Joint Diseases (BMJD), Bangkok, Thailand, 8-10 November 2018. 2018.
Lau W.C.S., JAK inhibitors review & Hong Kong consensus statement., Dinner Symposium arranged by Pfizer, Macau, 4 April 2019. 2019.
Lau W.C.S., JAK inhibitors review and consensus statement., 2019 Asia REACH Summit on Inflammation and Immunology. Le Meridien Hotel, Chiang Mai, Thailand, 26–27 January, 2019. 2019.
Lau W.C.S., Outstanding Community Service Award, Hang Seng-Regeneration Society. 2018.
Lau W.C.S., Patient Advocacy., Hong Kong Arthritis & Rheumatism Foundation Patient Conference, Hong Kong, August 2018. 2018.
Lau W.C.S., Presidents’ Round Table Discussion – Maintenance of competency., 52nd Malaysia-Singapore Congress of Medicine, Kuala Lumpur, July 2018. 2018.
Lau W.C.S., Revised APLAR rheumatoid arthritis treatment recommendations., 20th Asia Pacific League of Associations for Rheumatology, Kaohsiung, 7 September 2018. 2018.
Lau W.C.S., Status of Postgraduate Medical Training in Hong Kong., The Best Practice in Postgraduate Medical Education, Shenzhen, December 2018. 2018.
Lau W.C.S., The 2018 APLAR revised treatment recommendations for rheumatoid arthritis, 10th International Forum on Rheumatoid Arthritis, Beijing, 15 September 2018. 2018.
Lau W.C.S., The Development of Treatment Recommendations for Rheumatology Arthritis in the Asia Pacific region”?, International Conference of Chinese Rheumatologists (ICCR 2018), 17 November 2018. 2018.
Lau W.C.S., Training in medical ethics and morality., World Health Conference, The Chinese Medical Association, Hangzhou, October 2018.. 2018.
Lau W.C.S., Treating Rheumatoid Arthritis in Asia., Philippine Rheumatology Association (PRA) Annual Meeting 2019, SMX Convention Center, Lanang, Davao City, Philippines, 7-9 March 2019. 2019.
Lau W.C.S., Treatment of rheumatoid arthritis: The “orally available biologics”!, The British Medical Association (HK) Advance in Therapeutics Course 2019, Hong Kong 27 May 2019. 2019.
Lau W.C.S., Update on Management of Painful Arthritis., Annual Scientific Meeting in Anaesthesiology 2018, Hong Kong Convention and Exhibition Centre, 17 November 2018. 2018.
Lau W.C.S., Update on management of painful arthritis., Annual Scientific Meeting in Anaesthesiology 2018, Hong Kong Convention and Exhibition Centre, November 2018. 2018.
Lau W.C.S., What’s new with APLAR?, 2019 Asia REACH Summit on Inflammation and Immunology. Le Meridien Hotel, Chiang Mai, Thailand, 26–27 January, 2019. 2019.
Lau W.C.S., 大湾区医疗机构发展暨医疗人才培训研讨会 - 全科医生培训., Guangzhou August, 2018. 2018.
Lau W.C.S., 香港畢業後醫學模擬訓練與教員發展(Simulation training and faculty development)., 廣東省醫師協會畢業後醫學教育工作委員會年會 深圳 (20-21 April 2019). 2019.
Li P.H., Lee P.P.W., Fung S.L., Lau W.C.S. and Lu Y.L., Chronic mucocutaneous candidiasis—more than just skin deep, Hong Kong Medical Journal. 2018, 24(4): 423-425.
Li P.H., Chung H.Y., Wong C.S., Tsang H.H.L., Lau V.W.H., Ho G., XU X., Lau W.C.S. and Ma K.Y., The Association Between Age and Clinical and Radiological Activity in Axial Spondyloarthritis, Journal of Clinical Rheumatology and Immunology. 2019, 1-8.
Li Q., Wu H., Liao W., Zhao M., Chan V.S.F., Li L., Zheng M., Chen G., Zhang J., Lau W.C.S. and Lu Q., A comprehensive review of immune-mediated dermatopathology in systemic lupus erythematosus, Journal of Autoimmunity. 2018, 93: 1-15.
Sze S.Y., Chan V.S.F. and Lau W.C.S., Abnormal expression of long non-coding RNAs in systemic lupus erythematosus and lupus nephritis, 13th World Immune Regulation Meeting. 2019.
TSOI M.F., Cheung B.M.Y., Lau W.C.S. and Cheung T.T., Association between blood lead level and gout: the United States National Health Nutrition and Examination Survey 2007-2014, 24th Medical Research Conference. Hong Kong, Hong Kong Medical Journal, 2019, 25 (1), supp 1: 39.
TSOI M.F., Cheung B.M.Y., Lau W.C.S. and Cheung T.T., Incidence, prevalence, and utilisation of urate-lowering therapy in Hong Kong: a population-based study, 24th Medical Research Conference. Hong Kong, Hong Kong Medical Journal, 2019, 25 (1), supp 1: 41.
Tam L.S., Wei J.C.C., Aggarwal A., Baek H.J., Cheung P.P., Chiowchanwisawakit P., Dans L., Gu J., Hagino N., Kishimoto M., Reyes H.M., Soroosh S., Stebbings S., Whittle S., Yeap S.S. and Lau W.C.S., 2018 APLAR axial spondyloarthritis treatment recommendations, International Journal of Rheumatic Diseases. 2019, 22: 340-356.
Tsang H.L.H., Cheung J.P.Y., Wong C.K.H., Cheung W.H.P., Lau W.C.S. and Chung H.Y., Psychometric validation of the EuroQoL 5-dimension (EQ-5D) questionnaire in patients with spondyloarthritis, Arthritis Research & Therapy. 2019, 21: 41.
Wong S.P.Y., Mok C.C., Lau W.C.S., Yip M.L., Tam L.S., Ying K.Y., Ng W.L., Ng K.H., Leung M.H., Lee T.Y., To C.H., Lee K.L., Wan M.C., Yu K.L., Wong P.C.H., Sung C.K., Lee K.F. and Kun E.W.L., Clinical presentation, treatment and outcome of Takayasu’s arteritis in southern Chinese: a multicenter retrospective study, Rheumatology International. 2018.
Wu H., Liao W., Li Q., Long H., Yin H., Zhao M., Chan V.S.F., Lau W.C.S. and Lu Q., Pathogenic role of tissue-resident memory T cells in autoimmune diseases, Autoimmunity Reviews. 2018, 17: 906-911.
Yap Y.H.D., Tam C.H., Yung S.S.Y., Wong S., Tang S.O.C., Mok M.Y.T., Yuen C.K.Y., Ma M.K.M., Lau W.C.S. and Chan D.T.M., Pharmacokinetics and pharmacogenomics of mycophenolic acid and its clinical correlations in maintenance immunosuppression for lupus nephritis, Nephrol Dial Transplant. 2018.
Yap Y.H.D., Tam C.H., Yung S.S.Y., Wong S., Tang S.O.C., Mok M.Y.T., Yuen K.Y.C., Ma K.M.M., Lau W.C.S. and Chan D.T.M., Pharmacokinetics and pharmacogenomics of mycophenolic acid and its clinical correlations in maintenance immunosuppression for lupus nephritis, Nephrology Dialysis Transplantation. 2018.
Yeung K.S., Lee T.L., Mok M.Y., Mak C.C.Y., Yang W., Chong C.Y., Lee P.P.W., Ho M.H.K., Choufani S., Lau W.C.S., Lau Y.L., Weksberg R. and Chung B.H.Y., Cell Lineage-specific Genome-wide DNA Methylation Analysis of Patients with Paediatric-onset Systemic Lupus Erythematosus, Epigenetics. 2019.


Researcher : Lee CHA

List of Research Outputs

Chan M.L., Cheung C.L., Lee C.H.A., Yeung C.Y., Siu D.C.W., Leung J.Y., Pang H.K. and Tan K.C.B., Genetic variations in familial hypercholesterolemia and cascade screening in East Asians, Mol Genet Genomic Med. 2019, 7(2): e00520.
Lee C.H.P., Woo Y.C., Lam K.Y.J., Lee C.H.A., Lam K.S.L. and Tan K.C.B., The effects of insulin treatment on circulating ketone levels in patients with type 2 diabetes on sodium-glucose co-transporter 2 inhibitors, American Diabetes Association 79th Scientific Sessions, San Francisco, June 2019.
Lui D.T.W., Woo Y.C., Chow W.S., Lee C.H.P., Lee C.H.A., Leung E.K.H., Tan K.C.B., Lam K.S.L. and Lam K.Y.J., Glycogenic hepatopathy as an unusual etiology of deranged liver function in a patient with type 1 diabetes, Medicine. 2019, 98: e15296.
Tan K.C.B., Cheung C.L., Lee C.H.A., Lam J.K.Y., Wong Y. and Shiu S.W.M., Galectin-3 and risk of cardiovascular events and all-cause mortality in type 2 diabetes, Diabetes Metab Res Rev. 2019, 35(2): e3093.


Researcher : Lee CHP

Project Title:The Role of Novel Serum Biomarkers and Dietary Pattern in Non-Alcoholic Fatty Liver Disease among Chinese patients with Type 2 Diabetes in Hong Kong
Investigator(s):Lee CHP, Lam KSL
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research for New Staff
Start Date:06/2016


Project Title:Adipocyte fatty acid binding protein as a novel marker of the development of sight threatening diabetic retinopathy
Investigator(s):Lee CHP, Lam KSL, Yuen MAM, Wong YHI, Fong HY
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:04/2017


Project Title:Establishing an Optimal Genetic Screening Strategy for Identification of Germline Mutation in Southern Chinese with Phaeochromocytoma and Paraganglioma
Investigator(s):Lee CHP, Cheung YY
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:07/2018


List of Research Outputs

Cheung Y.Y., Lee C.H.P., Tang S.M., Xu A., Au K.W., Fong H.Y., Ng K.K., KWOK H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Hai S.H.J.J., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Genetic regulation of Pigment Epithelium-Derived Factor (PEDF): an exome-chip association analysis in Chinese subjects with type 2 diabetes, Diabetes. 2019, 68: 198-206.
Lee C.H.P., Adipocyte fatty acid binding protein and diabetic kidney disease, Asia Pacific Diabetes & Obesity Symposium (APDO), 8-9 Oct 2018, Kobe, Japan. 2018.
Lee C.H.P., Woo Y.C., Lam K.S.L. and Tan K.C.B., Case series of Chinese patients with dysthyroid optic neuropathy: a single centre audit, 5th International Thyroid Eye Disease Symposium, Singapore, Feb 2019.
Lee C.H.P., Cheung Y.Y., Woo Y.C., Lui D.T.W., Yuen M.A.M., Fong H.Y., Chow W.S., Xu A. and Lam K.S.L., Circulating Adipocyte Fatty Acid–Binding Protein Concentrations Predict Multiple Mortality Outcomes among Men and Women with Diabetes, Clinical Chemistry. 2018, clinchem.2018.289157.
Lee C.H.P., Clinical Update in Phaechromocytoma & Paraganglioma, The University of Hong Kong – Shenzhen Hospital Endocrine Forum 2019. 2019.
Lee C.H.P., Chan R.S.M., Wan Y., Woo Y.C., Cheung Y.Y., Fong H.Y., Cheung B.M.Y., Lam T.H., Janus E., Woo J. and Lam K.S.L., Dietary Intake of Anti-Oxidant Vitamins A, C, and E Is Inversely Associated with Adverse Cardiovascular Outcomes in Chinese—A 22-Years Population-Based Prospective Study, Nutrients. 2018, 10: 1664.
Lee C.H.P., Woo Y.C. and Lam K.S.L., Fighting the Health Challenges of Diabetes in Hong Kong: A Window Into Mainland China, American Journal of Public Health. 2018, 108: 1623-1624.
Lee C.H.P., HbA1c variability – A New Target?, The Xijing Diabetes and Endocrine Forum, Xian, China. 2019.
Lee C.H.P., Cheung Y.Y., Woo Y.C., Lui D.T.W., Yuen M.A.M., Fong H.Y., Chow W.S., Xu A. and Lam K.S.L., Prospective associations of circulating adipocyte fatty acid-binding protein levels with risks of renal outcomes and mortality in type 2 diabetes, Diabetologia. 2019, 62: 169-177.
Lee C.H.P., Woo Y.C., Lam K.Y.J., Lee C.H.A., Lam K.S.L. and Tan K.C.B., The effects of insulin treatment on circulating ketone levels in patients with type 2 diabetes on sodium-glucose co-transporter 2 inhibitors, American Diabetes Association 79th Scientific Sessions, San Francisco, June 2019.
Lui D.T.W., Woo Y.C., Chow W.S., Lee C.H.P., Lee C.H.A., Leung E.K.H., Tan K.C.B., Lam K.S.L. and Lam K.Y.J., Glycogenic hepatopathy as an unusual etiology of deranged liver function in a patient with type 1 diabetes, Medicine. 2019, 98: e15296.
Mak L.Y., Lee C.H.P., Cheung K.S.M., Wong D.K.H., LIU F., Hui R.W., Fung J.Y.Y., Xu A., Lam K.S.L., Yuen R.M.F. and Seto W.K.W., Association of adipokines with hepatic steatosis and fibrosis in chronic hepatitis B patients on long‐term nucleoside analogue, Liver International. 2019, 39(7): 1217-1225.
Shih K.C., Poon S., Yu S., Li R., Seng C., Lam I., Hui J., Fong H.Y., Fung N.S.K. and Lee C.H.P., Efficacy of an endocrinologist-led specialist care clinic in minimizing burden of vision-threatening retinopathy in Chinese diabetic patients, 2019 Annual Meeting of the Association for Research in Vision and Ophthalmology. 2019.
Wong Y.K., Cheung Y.Y., Tang S.M., Au K.W., Hai S.H.J.J., Lee C.H.P., Lau G.K.K., Cheung B.M.Y., Sham P.C., Xu A., Lam K.S.L. and Tse H.F., Age-Biomarkers-Clinical Risk Factors for Prediction of Cardiovascular Events in Patients With Coronary Artery Disease., Arterioscler Thromb Vasc Biol. American Heart Association, Inc., 2018, 38: 2519-2527.


Researcher : Lee CMN

List of Research Outputs

Kwok H.H., Lee C.M.N., Deng J., Ip M.S.M. and Lam C.L.D., Lung cancer patient–derived organoid biobank for therapeutic screening, 24th Medical Research Conference, Department of Medicine, HKU, Feb 2019. Hong Kong Medical Journal. 2019, 25 (Suppl.1): 24.


Researcher : Lee P

List of Research Outputs

Singh G.H.H., Ip H.W., Yim R.L.H., Tang W.F., Pang H.M.H., Lee P., Leung G.M.K., Li J.W.Y., Tang K., So J.C.C., Leung R.Y.Y., Li J., Panagiotou I., Lam C.C.K. and Kwong Y.L., Next-generation sequencing with a 54-gene panel identified unique mutational profile and prognostic markers in Chinese patients with myelofibrosis, Annals of Hematology. 2018.


Researcher : Lee YK

Project Title:Validation of preclinical molecular diagnosed hypertrophic cardiomyopathy (HCM) using patient specific human induced pluripotent stem cell (hiPSC) platform-new perspectives in personalized drug-screening
Investigator(s):Lee YK
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:04/2018


Project Title:European Society of Cardiology (ESC) Congress 2018; Disease modeling of laminopathy-related dilated cardiomyopathy (DCM) - Proarrhythmic effects and electrical-contraction (EC) coupling defeats due to altered mechanosensitivity of lamin A
Investigator(s):Lee YK
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:08/2018
Completion Date:08/2018


Project Title:Precision medicine towards familial cardiac laminopathy
Investigator(s):Lee YK, Siu DCW, Tse HF
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:05/2019


List of Research Outputs

Lee Y.K., Travel awards for European Society of Cardiology (ESC) Congress, European Society of Cardiology (ESC) . 2018.
Lee Y.K., University of Hong Kong/ China Medical Broad Grants 2018/2019 (First Round), Hong Kong/ China Medical Broad. 2019.
Mura M., Lee Y.K., Pisano F., Ginevrino M., Boni M., Calabrò F., Crotti L., Schwartz P.J., Tse H.F. and Gnecchi M., Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation. , Stem Cell Res. 2019.
Mura M., Lee Y.K., Pisano F., Ginevrino M., Boni M., Calabrò F., Crotti L., Schwartz P.J., Tse H.F. and Gnecchi M., Generation of the human induced pluripotent stem cell (hiPSC) line PSMi005-A from a patient carrying the KCNQ1-R190W mutation., Stem Cell Res. 2019, 37.
Ng K.M., Lau V.Y.M., Vidhu D., Cai Z., Lee Y.K., Lai K.W.H., Tse H.F. and Siu D.C.W., Empagliflozin Ammeliorates High Glucose Induced-Cardiac Dysfuntion in Human iPSC-Derived Cardiomyocytes, Scientific Reports. 2018, 8.


Researcher : Lee YKM

List of Research Outputs

Lee Y.K.M., Ge M., Fung M.L., Vanhoutte P.M.G.R., Mak J.C.W. and Ip M.S.M., Low but not high frequency of intermittent hypoxia suppresses endothelium-dependent, oxidative stress-mediated contractions in carotid arteries of obese mice, Journal of Applied Physiology. 2018, 125: 1384-1395.
WANG Y., Lee Y.K.M., Mak J.C.W. and Ip M.S.M., Low-Frequency Intermittent Hypoxia Suppresses Subcutaneous Adipogenesis and Induces Macrophage Polarization in Lean Mice, Diabetes Metab J. 2019.


Researcher : Leung AYH

Project Title:Detection of WU and KI polyomaviruses from patients with acute respiratory tract infections in Hong Kong
Investigator(s):Leung AYH, Kwong YL
Department:Medicine
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:01/2009


Project Title:Study of Microglia and Myeloid Leukemia in Zebrafish
Investigator(s):Leung AYH
Department:Medicine
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:05/2013


Project Title:Provision of free Sorafenib for patients with refractory or relapsed acute myeloid leukemia to bridge them to curative bone marrow transplantation
Investigator(s):Leung AYH
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:01/2014
Completion Date:12/2018


Project Title:Development of Cell Manipulation Tools for Probing Functional Mechanism of Hematopoietic Cells: Robotics, Optical tweezers, and Hematopoiesis
Investigator(s):Leung AYH
Department:Medicine
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:06/2014


Project Title:Provision of free next generation sequencing (NGS) service of prognostic and therapeutic values for patients with acute myeloid leukemia in Hong Kong
Investigator(s):Leung AYH
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:03/2016


Project Title:Establish a zebrafish model to study the molecular and clonal heterogeneity and develop personalized treatment in FLT3-ITD+ AML
Investigator(s):Leung AYH
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:09/2016


Project Title:A Comprehensive and Multidisciplinary Approach Targeting Acute Myeloid Leukaemia in Hong Kong (TRS)
Investigator(s):Leung AYH
Department:Medicine
Source(s) of Funding:Seed Funding for Strategic Interdisciplinary Research Scheme
Start Date:06/2017


Project Title:Targeting DNA damage and repair mechanism in FLT3-ITD acute myeloid leukaemia (AML) - a mechanistic and therapeutic study
Investigator(s):Leung AYH
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:07/2017


Project Title:Follistatin as a novel target and biomarker for acute myeloid leukaemia (AML) carrying internal tandem duplication (ITD) of Fms-Like Tyrosine kinase 3 (FLT3).
Investigator(s):Leung AYH
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2018


Project Title:Develop a high throughput platform for personalized treatment of acute myeloid leukaemia
Investigator(s):Leung AYH
Department:Medicine
Source(s) of Funding:Croucher Senior Medical Research Fellowships
Start Date:01/2018


Project Title:Provision of Free Azacitidine as Maintenance Therapy for Haematopoietic Stem Cell Transplant Recipients at High Risk of Relapse from Acute Myeloid Leukaemia
Investigator(s):Leung AYH
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:06/2018


Project Title:Outstanding Research Student Supervisor Award 2017-18
Investigator(s):Leung AYH
Department:Medicine
Source(s) of Funding:Outstanding Research Student Supervisor Award
Start Date:12/2018


List of Research Outputs

Kwok W.C., Liang B.M., Lui M.S.M., Tam C.C.T., Sim P.Y.J., Tse E.W.C., Leung A.Y.H., Kwong Y.L., Lie A.K.W., Ip M.S.M. and Lam C.L.D., Rapid versus gradual lung function decline in bronchiolitis obliterans syndrome after haematopoietic stem cell transplantation is associated with survival outcome, Respirology. 2019, 24: 459-466.
Leung K.C., Luk H.M., Tang H.M.V., Gao W., MAK C.C.Y., YU H.C., Wong W.L., Chu W.Y., Yang W., Wong W.H.S., Ma C.H., Leung A.Y.H., Jin D., Chan Y.K., Allanson J., Lo F.M.I. and Chung B.H.Y., Integrating Functional Analysis in the Next-Generation Sequencing Diagnostic Pipeline of RASopathies, Scientific Reports. 2018, 8: 2421.


Researcher : Leung CTG

List of Research Outputs

Ho W.L., Leung C.T.G., Liu H., Pang S.Y.Y., Lam C.S.C., Xian J., Li L., Kung M.H.W., Ramsden D.B. and Ho S.L., Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA), Autophagy. 2019, 1-24.


Researcher : Leung JCK

Project Title:Macrophage–Myofibroblast-Transition in Organ Fibrosis: Molecular Mechanisms and Clinical Implications
Investigator(s):Leung JCK
Department:Medicine
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:06/2013


List of Research Outputs

Chan K.W., Kwong A.S.K., Chan G.C.W., Leung C.P.S., Yiu W.H., Lui S.L., Ip T.P., Cowling B.J., Wong W.L.D., LI B., LI Y., Feng Y., Chan L.Y.Y., Leung J.C.K., Tan K.C.B., Wong C.W.V., Lai K.N. and Tang S.C.W., Best Poster Award, Good Practice In Traditional Chinese Medicine Research Association. 2018.
Chan K.W., Kwong A.S.K., Chan G.C.W., Leung C.P.S., Yiu W.H., Lui S.L., Ip T.P., Cowling B.J., Wong W.L.D., LI B., LI Y., Feng Y., Chan Y.Y., Leung J.C.K., Tan K.C.B., Wong C.W.V., Lai K.N. and Tang S.C.W., Semi-individualised Chinese Medicine Treatment for Diabetic Kidney Disease – From users’ perspectives to SCHEMATIC trial interim result and potential mechanisms, Advances in Integrative Medicine (International Congress on Complementary Medicine Research). 2019, 6: S12.
LI B., Leung J.C.K., Chan Y.Y., Yiu W.H., LI Y., LOK W.Y., Liu W.H., Chan K.W., Tse H.F., Lai K.N. and Lai K.N., Amelioration of Endoplasmic Reticulum Stress by Mesenchymal Stem Cells Via Hepatocyte Growth Factor/c‐Met Signaling in Obesity‐Associated Kidney Injury, STEM CELLS Translational Medicine. 2019.
LI B., Leung J.C.K., Chan L.Y., Yiu W.H., Lai K.N. and Tang S.C.W., Mesenchymal Stem Cells Derived from Induced Pluripotent Stem Cells and Bone Marrow Are Equally Effective in Ameliorating Lipotoxicity-Induced Kidney Injury (Conference Abstract)., J Am Soc Nephrol. 2018, 29: 284.
Leung J.C.K., Lai K.N. and Tang S.C.W., Role of Mesangial-Podocytic-Tubular Cross-Talk in IgA Nephropathy, Seminars in Nephrology. 2018, 38: 485-495.
Yiu W.H., Wong D.W., LOK W.Y., Liu W.H., LI Y., CHAN L.Y., Leung J.C.K., Lan H.Y. and Tang S.C.W., The Long Noncoding RNA Meg3 Mediates TLR4–Induced Renal Inflammation in Experimental Obstructive Nephropathy (Conference Abstracts) , J Am Soc Nephrol . 2018, 29: 953.


Researcher : Leung KP

List of Research Outputs

DENG X., CHAU L.H., CHIU S.Y., Leung K.P., Hu Y. and Ip W.Y., Diagnostic use of ultrasonography in carpal tunnel syndrome and its correlation with the Chinese version of boston carpal tunnel questionnaire, Journal of Medical Ultrasound. 2019, 27: 124.
DENG X., CHAU L.H., CHIU S.Y., Leung K.P., Hu Y. and Ip W.Y., Prognostic value of ultrasonography in predicting therapeutic outcome for carpal tunnel syndrome after conservative treatment: A retrospective long-term follow-up study, Journal of Medical Ultrasound. 2019, 0: 0.
DENG X., CHAU L.H., CHIU S.Y., Leung K.P., Hu Y. and Ip W.Y., Screening of Axonal Degeneration in Carpal Tunnel Syndrome Using Ultrasonography and Nerve Conduction Studies, Journal of Visualized Experiments. 2019.


Researcher : Leung RCY

List of Research Outputs

Chiu W.Y.J., Leung R.C.Y., Tang Y.F.V., Cheuk W.Y.I., Lo L.F., Kwok G.W., Wong H.Y.H., Suen T.K.D., Cheung P., Wong T.T., Yau T.C.C. and Kwong A., Changing pattern of recurrences in patients with early HER2-positive breast cancer receiving neoadjuvant chemotherapy in the era of dual anti-HER2 therapy, Postgraduate Medical Journal. 2019, 95: 155-161.
Kwong A., Cheng D.K.L., Hsue C.C., Hui S.K., Leung R.C.Y., Leung K.C., Ngan K.C.R. and Soong S.I., BRCA mutation testing for ovarian cancer in the context of available targeted therapy: survey and consensus of Hong Kong specialists, Asia-Pacific Journal of Clinical Oncology. 2019, 15(Suppl.): 20-31.
Woo P.Y.M., Lam T.C., Pu K.S.J., Li L.F., Leung R.C.Y., Ho J.M.K., Zhung J.T.F., Wong B., Chan T.S.K., Loong H.H.F. and Ng H.K., Regression of BRAF mutant adult glioblastoma after primary combined BRAF-MEK inhibitor targeted therapy: a report of two cases, Oncotarget. 2019, 10(38): 3818-3826.


Researcher : Leung WK

Project Title:Use of Fecal Calprotection for Diagnosis and Monitoring of Patients with Inflammatory Bowel Disease
Investigator(s):Leung WK, Hung FNI, Liu SHK
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:03/2016
Completion Date:02/2019


Project Title:Provision of Small Bowel Capsule Endoscopy and Balloon-Assisted Enteroscopy to Patients with Small Bowel Diseases
Investigator(s):Leung WK, Hung FNI, Wong SY, But YKD, Liu SHK
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:03/2018


Project Title:Digestive Disease Week 2019; A prospective randomized tandem colonoscopy study of linked color imaging or narrow band imaging for detection of colorectal polyp
Investigator(s):Leung WK
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:05/2019
Completion Date:05/2019


List of Research Outputs

Cheung K.S.M., Leung W.K. and Seto W.K.W., Application of Big Data analysis in gastrointestinal research, World Journal of Gastroenterology. 2019, 25: 2990-3008.
Cheung K.S.M., Chen L., Seto W.K.W. and Leung W.K., Best Abstract Award in Clinical Medicine (oral presentation), 24th Medical Research Conference, Hong Kong, The University of Hong Kong . 2019.
Cheung K.S.M., Chen L., Seto W.K.W. and Leung W.K., Epidemiology, characteristics and survival of post-colonoscopy colorectal cancer in Hong Kong: a population-based study, Medical Research Conference. 2019.
Cheung K.S.M., Chen L., Seto W.K.W. and Leung W.K., Epidemiology, characteristics and survival of post‐colonoscopy colorectal cancer in Asia: a population‐based study, Journal of Gastroenterology and Hepatology. 2019.
Cheung K.S.M. and Leung W.K., Long-term use of proton-pump inhibitors and risk of gastric cancer: a review of the current evidence, Therapeutic Advances in Gastroenterology. 2019, 12: 175628481983451.
Cheung K.S.M., Chan E.W., Wong A.Y., Chen L., Seto W.K.W., Wong I.C.K. and Leung W.K., Metformin Use and Gastric Cancer Risk in Diabetic Patients After Helicobacter pylori Eradication, JNCI: Journal of the National Cancer Institute. 2018.
Cheung K.S.M. and Leung W.K., Response to Khosrow-Khavar, Kurteva, and Douros, JNCI: Journal of the National Cancer Institute. 2019.
Cheung K.S.M. and Leung W.K., Response to letter to the editor by Moayyedi et al , Gut. 2018, gutjnl-2018-317127.
Cheung K.S.M., Chan E.W.Y., Wong A.S.Y., Chen L., Seto W.K.W., Wong I.C.K. and Leung W.K., Statin use and gastric cancer risk in Helicobacter pylori-eradicated patients: a territory-wide study with propensity score matching, Medical Research Conference, Hong Kong. 2019.
Cheung K.S.M., Chen L., Chan E.W., Seto W.K.W., Wong I.C.K. and Leung W.K., Statins reduce the progression of non-advanced adenomas to colorectal cancer: a postcolonoscopy study in 187 897 patients, Gut. 2019, gutjnl-2018-317714.
Cheung K.S.M., Chan E.W.Y., Chen L., Seto W.K.W., Wong I.C.K. and Leung W.K., Use of non-aspirin non-steroidal anti-inflammatory drugs and risk of post-colonoscopy colorectal cancer: a territory-wide study with propensity score analysis, Digestive Disease Week . 2019.
GUO C., Cheung K.S.M., Zhang F., Chan E.W.Y., Chen L., Wong I.C.K. and Leung W.K., Incidences, temporal trends and risks of hospitalisation for gastrointestinal bleeding in new or chronic low-dose aspirin users after treatment for Helicobacter pylori : a territory-wide cohort study , Gut. 2019, gutjnl-2019-318352.
GUO C., Chen L., Chan E.W.Y., Cheung K.S.M., Isshiki T., Wong I.C.K. and Leung W.K., Systematic review with meta- analysis: the risk of gastrointestinal bleeding in patients taking third-generation P2Y12 inhibitors compared with clopidogrel, Alimentary Pharmacology & Therapeutics. 2019.
Lam Y.F., Seto W.K.W., Tong S.M., Cheung K.S.M., Lo O.S.H., Hung F.N.I., Law W.L. and Leung W.K., Rates of metachronous adenoma after curative resection for left-sided or right-sided colon cancer, Intestinal Research. 2018, 16: 619-627.
Leung W.K., Chen L., Seto W.K.W. and Cheung K.S.M., Characteristics and risk factors of post-colonoscopy interval cancers: a population-based study from Asia, Digestive Disease Week. 2019.
Lui K.L., Wong K.K.Y. and Leung W.K., Artifical Intelligence Image Classifier Based on Nonoptical Magnified Images Accurately Predicts Histology and Endoscopic Resectability of Different Colonic Lesions, Gastroenterology. 2019, 156(6): S-48.
Lui K.L., Wong K.K.Y., Mak L.L.Y., Ko M.K.L., Tsao S.K.K. and Leung W.K., Endoscopic prediction of deeply submucosal invasive carcinoma with use of artificial intelligence, Endoscopy International Open. 2019, 7(4): E514-E520.
Lui K.L., Wong K.K.Y. and Leung W.K., Use Of Artificial Intelligence Image Classifier For Real-time Detection Of Colonic Polyps, Gastrointestinal Endoscopy. 2019, 89(6): AB135.
Lui K.L., Wong K.K.Y., Ko M.K.L., Mak L.Y., Tsui V.W.M. and Leung W.K., Use Of Artificial Intelligence Image Classifier To Predict Histology Of Solitary Sessile Gastric Lesions And Comparison With Junior Endoscopists, Gastrointestinal Endoscopy. 2019, 89(6): AB617-AB618.
Ma Z., Williams M., Cheng Y.Y. and Leung W.K., Roles of Methylated DNA Biomarkers in Patients with Colorectal Cancer, Disease Markers. Hindawi, 2019, 2019: 1-8.
Mak L.Y., Lau C.W., Hui Y.T., Ng C., Shan E., Li M.K.K., Lau J.Y.W., Chiu P.W.Y., Leong H.T., Ho J., Wu J.C.Y., Lee C.K. and Leung W.K., Joint recommendations on management of anaemia in patients with gastrointestinal bleeding in Hong Kong, Hong Kong Medical Journal. 2018, 416-422.
Mak W.Y., Mak O.S., Lee C.K., Tang W., Leung W.K., Wong M.T.L., Sze A.S.F., Li M., Leung C.M., Lo F.H., Lam B.C.Y., Chan K.H., Shan E.H.S., Tsang S.W.C., Hui A.J., Chow W.H., Chan F.K.L., Sung J.J.Y. and Ng S.C., Significant medical and surgical morbidity in perianal Crohn’s disease: Results from a territory-wide study, Journal of Crohn's and Colitis. 2018.
Ooi C.J., Hilmi I., Banerjee R., Chuah S.W., Ng S.C., Wei S.C., Makharia G.K., Pisespongsa P., Chen M.H., Ran Z.H., Ye B.D., Park D.I., Ling K.L., Ong D., Ahuja V., Goh K.L., Sollano J., Lim W.C., Leung W.K., Raja Ali R.A., Wu D.C., Ong E., Mustaffa N., Limsrivilai J., Hisamatsu T., Yang S.K., Ouyang Q., Geary R., De Silva J.H., Rerknimitr R., Simadibrata M., Abdullah M. and Leong R.W.L., Best practices on immunomodulators and biological agents for Ulcerative colitis and Crohn's disease in Asia, Journal of Gastroenterology and Hepatology. 2019.
Zimmermann-Fraedrich K., Sehner S., Rex D.K., Kaltenbach T., Soetniko R., Wallace M., Leung W.K., GUO C., Gralnek I.M., Brand E.C., Growth S., Schachschai G., Ikematsu H., Siersema P.D. and Rosch T., Right-Sided Location Not Associated With Missed Colorectal Adenomas in an Individual-Level Reanalysis of Tandem Colonoscopy Studies, Gastroenterology. 2019.
zhang L.F., Mao M.Y., Ye W., Yang Y.T., Leung W.K., Chu K.M., Huang F.Y. and Todsico A.N.D.R.E.A., REGULATION OF THE BMP SIGNALING INHIBITOR SMAD6 IN GASTRITIS AND GASTRIC CANCER, DDW 2019. 156: S-273.


Researcher : Li C

List of Research Outputs

JIANG D., XIONG G., FENG H., ZHANG Z., Chen P., Yan B., CHEN L., Kesavamoorthy G., MA C.Y., Li C., HAN S., Zhang Y., Liao C., Lee T.L., Tse H.F., Fu Q.L., Chiu K. and Lian Q., Donation of mitochondria by iPSC-derived mesenchymal stem cells protects retinal ganglion cells against mitochondrial complex I defect-induced degeneration, Theranostics. Australia, Ivyspring International Publisher, 2019, 2019, Vol. 9, Issue 8: 2395-2410.
Jiang D., Xiong G., Feng H., ZHANG Z., Chen P., Yan B., Chen P., Kesavamoorthy G., Ma C.Y., Li C., Han S., Zhang Y., Liao C., Lee T.L., Tse H.F., Fu Q., Chiu K. and Lian Q., Donation of mitochondria by iPSC-derived mesenchymal stem cells protects retinal ganglion cells against mitochondrial complex I defect-induced degeneration, Theranostics. 2019, 9(8): 2395-2410.


Researcher : Li G

Project Title:Volume-sensitive chloride current and cell volume regulation in human atrial myocytes
Investigator(s):Li GR, Lau CP, Chiu SW, Tse HF
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:12/2001




Researcher : Li GR

Project Title:Volume-sensitive chloride current and cell volume regulation in human atrial myocytes
Investigator(s):Li GR, Lau CP, Chiu SW, Tse HF
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:12/2001




Researcher : Li J

Project Title:Manipulation of the Gut Microbiota for Metabolic Health; Adiponectin antagonizes dietary-induced metabolic diseases via modulation of gut microbiota
Investigator(s):Li J
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:03/2018




Researcher : Li L

List of Research Outputs

Ho W.L., Leung C.T.G., Liu H., Pang S.Y.Y., Lam C.S.C., Xian J., Li L., Kung M.H.W., Ramsden D.B. and Ho S.L., Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA), Autophagy. 2019, 1-24.


Researcher : Li LSW

List of Research Outputs

CHEN S., XU X., Lau G.K.K., Li L.S.W., WONG Y.K., Yau C., Mak H.K.F., Chan Q., Chang H.C.C. and Hui S.K., The association between functional brain network and functional outcome after acute ischemic stroke, The 26th Annual Meeting of the International Society for Magnetic Resonance in Medicine. 2019, 3895.


Researcher : Li YV

List of Research Outputs

Lam S.K., U K.P., Li Y.V., XU S., Cheng P.N. and Ho J.C.M., Inhibition of ornithine decarboxylase 1 facilitates pegylated arginase treatment in lung adenocarcinoma xenograft models, Oncology Reports. 2018.


Researcher : Lian Q

Project Title:The Roles and Mechanisms of human mesenchymal stem cell-mediated cardial protection against anthracycline-induced cardiomyopathy
Investigator(s):Lian Q
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:05/2012


Project Title:The Roles and Mechanisms of RAP1/NFkb signaling pathway in MSC-induced immunomodulation for organ transplantation
Investigator(s):Lian Q, Poon MW, He J
Department:Medicine
Source(s) of Funding:National Natural Science Foundation of China (NSFC) - General Program
Start Date:01/2013


Project Title:Platform of Human Pluripotent Stem Cell-derived Mesenchymal Stem Cells for Tissue Regeneration and Industrial Application
Investigator(s):Lian Q, Tse HF, Poon MW
Department:Medicine
Source(s) of Funding:Innovation and Technology Support Programme (Tier 3)
Start Date:01/2013


Project Title:Platform of Human Pluripotent Stem Cell-derived Mesenchymal Stem Cells for Tissue Regeneration and Industrial Application
Investigator(s):Lian Q, Tse HF, Poon MW
Department:Medicine
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:04/2013


Project Title:Generation, Purification and Transplantation of human Pluripotent Stem Cell -derived Cone and Rod Photoreceptor Cells for Retinal Degenerative Disease
Investigator(s):Lian Q, Wong DSH
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:05/2013


Project Title:International Society for Stem Cell Research 11th Annual Meeting; ACTIVATION OF NRG1/ERBB4 SIGNALING PATHYWAY IN MESENCHYMAL STEM CELLS ENHANCES CELL SURVIAL AND PARACRINE POTENTIALS AGAINST MYOCARDIAL INFARCTION
Investigator(s):Lian Q
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2013


Project Title:Platform of Human Pluripotent Stem Cell-derived Mesenchymal Stem Cells for Tissue Regeneration and Industrial Application
Investigator(s):Lian Q, Tse HF, Poon MW
Department:Medicine
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:07/2013


Project Title:Functional roles of human ESC/iPSC-derived mesenchymal stem cell-deposited matrixes for improving survive and functions of retinal pigment epithelial cell (RPE)
Investigator(s):Lian Q
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:06/2014


Project Title:Functional Roles of Procollagen 2a1 in the Regulation of Nkx2.5+Cardiac Progenitor Cells for Myocardial Regeneration
Investigator(s):Lian Q, Zhang Y
Department:Ophthalmology
Source(s) of Funding:National Natural Science Foundation of China (NSFC) - General Program
Start Date:01/2016


Project Title:Human induced pluripotent stem cells derived-nucleus pulposus cells for intervertebral disc degeneration in rats
Investigator(s):Lian Q, Zhang Y, Cheah KSE
Department:Ophthalmology
Source(s) of Funding:AO Spine Asia Pacific
Start Date:06/2016


Project Title:Regulation of mitochondrial transfer potency by Kif5b in mesenchymal stem cells to rescue mitochondrial dysfunction-provoked ganglion cell degeneration
Investigator(s):Lian Q, Huang J, Chiu K
Department:Ophthalmology
Source(s) of Funding:General Research Fund (GRF)
Start Date:12/2016
Completion Date:01/2019


Project Title:International Society of Stem Cell Research (ISSCR) 2018 annunal Meeting ; HUMAN ISOGENIC AND PATIENT’S PLURIPOTENT STEM CELLS TO MODEL BIETTI’S CRYSTALLINE RETINAL DYSTROPHY
Investigator(s):Lian Q
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2018


Project Title:Phenotypic Turnover of Cardiac Mesenchymal Stem Cells in Mitochondrial Stress is Regulated by mTORC1/AMPKα Activity through Targeting of DRP1
Investigator(s):Lian Q, Song Y, Tse HF
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research for Resubmission of GRF/ECS Proposals
Start Date:07/2018


Project Title:Using pluripotent stem cells-derived neural cells and brain organoids to investigate Huntington’s disease-provoked mitochondrial dysfunction
Investigator(s):Lian Q, Chang RCC
Department:LKS Medical Faculty
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:04/2019


List of Research Outputs

He H., Yu B., Liu Z., Ye G., You W., Hong Y., Lian Q., Zhang Y.L. and Li X., Vascular progenitor cell senescence in patients with Marfan syndrome, Journal of Cellular and Molecular Medicine. 2019.
JIANG D., XIONG G., FENG H., ZHANG Z., Chen P., Yan B., CHEN L., Kesavamoorthy G., MA C.Y., Li C., HAN S., Zhang Y., Liao C., Lee T.L., Tse H.F., Fu Q.L., Chiu K. and Lian Q., Donation of mitochondria by iPSC-derived mesenchymal stem cells protects retinal ganglion cells against mitochondrial complex I defect-induced degeneration, Theranostics. Australia, Ivyspring International Publisher, 2019, 2019, Vol. 9, Issue 8: 2395-2410.
Jiang D., Xiong G., Feng H., ZHANG Z., Chen P., Yan B., Chen P., Kesavamoorthy G., Ma C.Y., Li C., Han S., Zhang Y., Liao C., Lee T.L., Tse H.F., Fu Q., Chiu K. and Lian Q., Donation of mitochondria by iPSC-derived mesenchymal stem cells protects retinal ganglion cells against mitochondrial complex I defect-induced degeneration, Theranostics. 2019, 9(8): 2395-2410.
Liao S., Zhang Y., Ting S.H.E.R.W.I.N., ZHEN Z., Luo F.A.N., Zhu Z., JIANG Y., SUN S., Lai K.W.H., Lian Q. and Tse H.F., Potent immunomodulation and angiogenic effects of mesenchymal stem cells versus cardiomyocytes derived from pluripotent stem cells for treatment of heart failure, Stem Cell Research & Therapy. 2019, 10.
iang X.I.A.O.T.I.N.G., ding Y.U.E., inb F.A.N.G., Zhang Y., zhou X.I.A.O.H.U.I., meng Q.I.N.G.S.H.U., LU S.I.N.G.Y.U.E., jiang G.U.O.J.U.N., zhu H.O.N.G.M.I.N.G., chen Y.U., Lian Q., fan H.U.I.M.I.N. and liu Z.H.O.N.G.M.I.N., Overexpression of ERBB4 rejuvenates aged mesenchymal stem cells and enhances angiogenesis via PI3K/AKT and MAPK/ERK pathways , The FASEB Journal. 2019, 33: 4559-4570.
yao I.N., Fan X.I.N.G.-.L.I.A.N.G., JIANG D., Zhang Y., Li X.I.N., Xu Z.H.I.N.-.B.I.N., fANG S.H.U.-.B.I.N., CHIU S.I.N.M.I.N.G., Tse H.F., Lian Q. and Fu Q.L., Connexin 43-Mediated Mitochondrial Transfer of iPSC-MSCs Alleviates Asthma Inflammation, Stem Cell Reports. 2018, 11: 1120-1135.


Researcher : Liang Y

Project Title:18th World Congress of Basic and Clinical Pharmacology (WCP2018); Mito-TEMPO protects cardiomyocytes from cigarette smoke medium-induced inflammation and apoptosis in vitro
Investigator(s):Liang Y
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:07/2018
Completion Date:07/2018


List of Research Outputs

Au Y.N.E., Liang Y., Ip M.S.M., Zhang Y. and Mak J.C.W., Effects of Dendrobium officinale Polysaccharides in Cigarette Smoke-induced Inflammation in Human Airway Epithelial NCI-H292 Cells, 24th Medical Research Conference, Department of Medicine, HKU, Hong Kong Medical Journal. Hong Kong Medical Jouranal, 2019, 25: 9.
Liang Y., Ip M.S.M. and Mak J.C.W., (-)-Epigallocatechin-3-gallate suppresses cigarette smoke-induced inflammation in human cardiomyocytes via ROS-mediated MAPK and NF-κB pathways, Phytomedicine. 2019.
Liang Y., Ip M.S.M. and Mak J.C.W., Congress Bursary for 18th World Congress of Basic And Clinical Pharmacology (WCP2018), 18th World Congress of Basic And Clinical Pharmacology. 2018.
Liang Y., Ip M.S.M. and Mak J.C.W., Mito-TEMPO protects cardiomyocytes from cigarette smoke medium-induced inflammation and apoptosis in vitro, 18th World Congress of Basic And Clinical Pharmacology. 2018.
Liang Y., Tian L., Ho K.F., Ip M.S.M. and Mak J.C.W., Mitochondrial Toxicity of Fine Particulate Matter (PM2.5) Collected in Hong Kong in Human Airway Epithelial Cells, 24th Medical Research Conference, Department of Medicine, HKU, Hong Kong Medical Journal. Hong Kong Medical Journal, 2019, 25: 28.
Liang Y., Ip M.S.M. and Mak J.C.W., The Role of Mitochondria in Cigarette Smoke-induced Inflammation and Apoptosis in Cardiomyocytes, 22nd Annual Scientific Meeting of Institute of Cardiovascular Science and Medicine . Hong Kong, Journal of the Hong Kong College of Cardiology, 2018, 26: 108.
Wong S.M., Lam W., Ge M., Yeung S.C., Liang Y., Ip M.S.M. and Mak J.C.W., Cardiac and Pulmonary Inflammatory Responses by Intermittent Hypoxia in C57BL/6N and C57BL/6J Mouse Strains, 24th Medical Research Conference, Department of Medicine, HKU, Hong Kong Medical Journal. 2019, 25: 32.


Researcher : Liao S

Project Title:Myocardial Tissue Engineering with Cells Derived From Human-Induced Pluripotent Stem Cells and a Native Decellularized Placenta Scaffold
Investigator(s):Liao S, Tse HF
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research for Resubmission of GRF/ECS Proposals
Start Date:07/2018
Completion Date:11/2018


List of Research Outputs

Liao S., Zhang Y., Ting S.H.E.R.W.I.N., ZHEN Z., Luo F.A.N., Zhu Z., JIANG Y., SUN S., Lai K.W.H., Lian Q. and Tse H.F., Potent immunomodulation and angiogenic effects of mesenchymal stem cells versus cardiomyocytes derived from pluripotent stem cells for treatment of heart failure, Stem Cell Research & Therapy. 2019, 10.


Researcher : Lie AKW

List of Research Outputs

Kwok W.C., Liang B.M., Lui M.S.M., Tam C.C.T., Sim P.Y.J., Tse E.W.C., Leung A.Y.H., Kwong Y.L., Lie A.K.W., Ip M.S.M. and Lam C.L.D., Rapid versus gradual lung function decline in bronchiolitis obliterans syndrome after haematopoietic stem cell transplantation is associated with survival outcome, Respirology. 2019, 24: 459-466.


Researcher : Liu H

List of Research Outputs

Ho W.L., Leung C.T.G., Liu H., Pang S.Y.Y., Lam C.S.C., Xian J., Li L., Kung M.H.W., Ramsden D.B. and Ho S.L., Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA), Autophagy. 2019, 1-24.


Researcher : Liu SHK

List of Research Outputs

Liu S.H.K., Seto W.K.W., Lau E.H.Y., Wong D.K.H., Lam Y.F., Cheung K.S.M., Mak L.Y., Ko K.L., To W.P., Law M.W.K., Wu J.T.K., Lai C.L. and Yuen R.M.F., A territory-wide prevalence study on blood-borne and enteric viral hepatitis in Hong Kong, The Journal of Infectious Diseases. 2019, 219(12): 1924-1933.
Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Mak L.Y., Wong D.K.H., Fung J.Y.Y., Liu S.H.K., Cheung K.S.M., Lai C.L., Kwong Y.L. and Yuen R.M.F., Monitoring and Treatment of Patients Undergoing Immunotherapy With Anti-CD20 Who are Exposed to HBV, Clinical Gastroenterology and Hepatology. 2018, 17(7): 1410-1412.
Seto W.K.W., Liu S.H.K., Mak L.Y., Cheung K.S.M., Wong D.K.H., Liu F., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Treatment Cessation in Chronic Hepatitis B: Predicting Off-Treatment Durability Via Combination of Viral Markers, HEPATOLOGY. WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2018, 68: 248A-249A.
Yuen R.M.F., Liu S.H.K., Seto W.K.W., Wong D.K.H., Wong S.Y., Cheung K.S.M., Mak L.Y.L., Ko K.L.M., To W.P.E., Yuen J.C.H., Wu C.H., Cheng C.T.K., Wu J.T.K. and Lau E.H.Y., Faculty Knowledge Exchange Award, HKU LKS Faculty of Medicine. 2019.


Researcher : Liu WH

List of Research Outputs

LI B., Leung J.C.K., Chan Y.Y., Yiu W.H., LI Y., LOK W.Y., Liu W.H., Chan K.W., Tse H.F., Lai K.N. and Lai K.N., Amelioration of Endoplasmic Reticulum Stress by Mesenchymal Stem Cells Via Hepatocyte Growth Factor/c‐Met Signaling in Obesity‐Associated Kidney Injury, STEM CELLS Translational Medicine. 2019.
Yiu W.H., Wong D.W., LOK W.Y., Liu W.H., LI Y., CHAN L.Y., Leung J.C.K., Lan H.Y. and Tang S.C.W., The Long Noncoding RNA Meg3 Mediates TLR4–Induced Renal Inflammation in Experimental Obstructive Nephropathy (Conference Abstracts) , J Am Soc Nephrol . 2018, 29: 953.


Researcher : Liu Y

Project Title:Exercise Metabolism; Gut microbiota and its metabolites mediate the heterogeneous glycemic responses to exercise intervention
Investigator(s):Liu Y
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:05/2019
Completion Date:05/2019


List of Research Outputs

CHEN Y., Liu Y., Seto W.K.W., Wu M., YU Y., Lam Y.M., Au W.K., Chan D., Sit K.Y., Ho L.M., Tse H.F. and Yiu K.H., Prognostic Value of Hepatorenal Function By Modified Model for End‐stage Liver Disease (MELD) Score in Patients Undergoing Tricuspid Annuloplasty, Journal of the American Heart Association. 2018, 7: e009020.
Chen Y., Liu Y., Seto W.K.W., Wu M., YU Y., Lam Y.M., Au T.W.K., Sit K.Y., Ho L.M., Tse H.F. and Yiu K.H., Prognostic Value of Hepatorenal Function By Modified Model for End-stage Liver Disease (MELD) Score in Patients Undergoing Tricuspid Annuloplasty, Journal of the American Heart Association. 2018, 7(14): 1-11.
Chen Y., Liu Y., Wu M., Lam Y.M., Ho L.M., Lau C.P., Au T.W.K., Tse H.F. and Yiu K.H., Prognostic value of tricuspid valve geometry and leaflet coaptation status in patients undergoing tricuspid annuloplasty: a three-dimensional echocardiography study, PCR Tokyo Valves 2019.
WANG X., Liu Y., Xu A. and Leung W.K., Alveolar and tibial bone status in obese mice with exercise, Journal of Dental Research. 2018, 97 (Spec Iss B): 3510.


Researcher : Liu Y

List of Research Outputs

CHEN Y., Liu Y., Seto W.K.W., Wu M., YU Y., Lam Y.M., Au W.K., Chan D., Sit K.Y., Ho L.M., Tse H.F. and Yiu K.H., Prognostic Value of Hepatorenal Function By Modified Model for End‐stage Liver Disease (MELD) Score in Patients Undergoing Tricuspid Annuloplasty, Journal of the American Heart Association. 2018, 7: e009020.
Chen Y., Liu Y., Seto W.K.W., Wu M., YU Y., Lam Y.M., Au T.W.K., Sit K.Y., Ho L.M., Tse H.F. and Yiu K.H., Prognostic Value of Hepatorenal Function By Modified Model for End-stage Liver Disease (MELD) Score in Patients Undergoing Tricuspid Annuloplasty, Journal of the American Heart Association. 2018, 7(14): 1-11.
Chen Y., Liu Y., Wu M., Lam Y.M., Ho L.M., Lau C.P., Au T.W.K., Tse H.F. and Yiu K.H., Prognostic value of tricuspid valve geometry and leaflet coaptation status in patients undergoing tricuspid annuloplasty: a three-dimensional echocardiography study, PCR Tokyo Valves 2019.
WANG X., Liu Y., Xu A. and Leung W.K., Alveolar and tibial bone status in obese mice with exercise, Journal of Dental Research. 2018, 97 (Spec Iss B): 3510.


Researcher : Lo WK

List of Research Outputs

Wong C.K.H., Chen J.Y., Fung S.K.S., Mok M.Y., Cheng Y.L., Kong I., Lo W.K., Lui S.L., Chan D.T.M. and Lam C.L.K., Direct and indirect costs of end-stage renal disease patients in the first and second years after initiation of nocturnal home haemodialysis, hospital haemodialysis and peritoneal dialysis, Nephrology Dialysis Transplantation. 2018.


Researcher : Lui KL

List of Research Outputs

Hui Y.T., Wong G.L.H., Fung J.Y.Y., Chan H.L.Y., Leung N.W.Y., Liu S.D., Liu K., Ma Y.K., But Y.K.D., Mak W.Y., Chan J.M.C., Lai K.B., Loo C.K., Ng A.C.Y., Lai M.S., Chan C.W., Lau J.Y.L., Fan T.T.T., Hui A.J., Lam B.C.Y., Cheung W.I., Tsang O.T.Y., Lam K., Lai L.S.W., Luk W.F., Lao M.K.K., Lao W.C., Lam J.T.W., Tsang S.W.C., Kung K.N., Chow W.H., Tong R.K.N., Lui K.L., Shan E.H.S., Yuen R.M.F. and Wong V.W.S., Territory-wide population-based study of chronic hepatitis C infection and implications for hepatitis elimination in Hong Kong, Liver International. 2018, 38(11): 1911-1919.
Lui K.L., Wong K.K.Y. and Leung W.K., Artifical Intelligence Image Classifier Based on Nonoptical Magnified Images Accurately Predicts Histology and Endoscopic Resectability of Different Colonic Lesions, Gastroenterology. 2019, 156(6): S-48.
Lui K.L., Wong K.K.Y., Mak L.L.Y., Ko M.K.L., Tsao S.K.K. and Leung W.K., Endoscopic prediction of deeply submucosal invasive carcinoma with use of artificial intelligence, Endoscopy International Open. 2019, 7(4): E514-E520.
Lui K.L., Wong K.K.Y. and Leung W.K., Use Of Artificial Intelligence Image Classifier For Real-time Detection Of Colonic Polyps, Gastrointestinal Endoscopy. 2019, 89(6): AB135.
Lui K.L., Wong K.K.Y., Ko M.K.L., Mak L.Y., Tsui V.W.M. and Leung W.K., Use Of Artificial Intelligence Image Classifier To Predict Histology Of Solitary Sessile Gastric Lesions And Comparison With Junior Endoscopists, Gastrointestinal Endoscopy. 2019, 89(6): AB617-AB618.


Researcher : Lui MSM

List of Research Outputs

Kwok W.C., Ho J.C.M., Lam C.L.D., Lui M.S.M., Ip M.S.M. and Tam C.C.T., Efficacy of gefitinib at reduced dose in EGFR mutant non-small-cell lung carcinoma., 24th Medical Research Conference, Department of Medicine, HKU. Hong Kong Medical Journal. 2019, 25 (Suppl 1): 24.
Kwok W.C., Ho J.C.M., Lam C.L.D., Lui M.S.M., Ip M.S.M. and Tam C.C.T., Progression-free survival among progressed non-small-cell lung cancer with T790M mutation as guided by liquid versus tissue re-biopsy, 24th Medical Research Conference, Department of Medicine, HKU. Hong Kong Medical Journal. 2019, 25 (Suppl 1): 25.
Kwok W.C., Tam C.C.T., Lam C.L.D., Ip M.S.M. and Lui M.S.M., Pulmonary embolism developing after therapeutic drainage of malignant pleural effusions, Respiratory Medicine Case Reports. 2018, 25: 122-123.
Kwok W.C., Liang B.M., Lui M.S.M., Tam C.C.T., Sim P.Y.J., Tse E.W.C., Leung A.Y.H., Kwong Y.L., Lie A.K.W., Ip M.S.M. and Lam C.L.D., Rapid versus gradual lung function decline in bronchiolitis obliterans syndrome after haematopoietic stem cell transplantation is associated with survival outcome, Respirology. 2019, 24: 459-466.
Lui M.S.M., Tse H.F., Mak J.C.W., Lam C.L.D., Chan W.S., Chong W.C. and Ip M.S.M., Untreated Obstructive Sleep Apnea Is Associated With Myocardial Injury Independent of Blood Pressure Control in Hypertension, Journal of Clinical Sleep Medicine. 2018, 14: 1841-1847.
Xu P., Hui K.M.C., Lui M.S.M., Lam C.L.D., Fong D.Y.T. and Ip M.S.M., Incident Type 2 Diabetes in OSA and Effect of CPAP Treatment, Chest. 2019.


Researcher : Lui SL

List of Research Outputs

Chan K.W., Kwong A.S.K., Chan G.C.W., Leung C.P.S., Yiu W.H., Lui S.L., Ip T.P., Cowling B.J., Wong W.L.D., LI B., LI Y., Feng Y., Chan L.Y.Y., Leung J.C.K., Tan K.C.B., Wong C.W.V., Lai K.N. and Tang S.C.W., Best Poster Award, Good Practice In Traditional Chinese Medicine Research Association. 2018.
Chan K.W., Kwong A.S.K., Chan G.C.W., Leung C.P.S., Yiu W.H., Lui S.L., Ip T.P., Cowling B.J., Wong W.L.D., LI B., LI Y., Feng Y., Chan Y.Y., Leung J.C.K., Tan K.C.B., Wong C.W.V., Lai K.N. and Tang S.C.W., Semi-individualised Chinese Medicine Treatment for Diabetic Kidney Disease – From users’ perspectives to SCHEMATIC trial interim result and potential mechanisms, Advances in Integrative Medicine (International Congress on Complementary Medicine Research). 2019, 6: S12.
Lui S.L., Yap Y.H.D., Cheng C.C.V., Chan D.T.M. and Yuen K.Y., Clinical practice guidelines for the provision of renal service in Hong Kong: Infection Control in Renal Service, Nephrology. 2019, 24 Suppl 1: 98-129.
Wong C.K.H., Chen J.Y., Fung S.K.S., Mok M.Y., Cheng Y.L., Kong I., Lo W.K., Lui S.L., Chan D.T.M. and Lam C.L.K., Direct and indirect costs of end-stage renal disease patients in the first and second years after initiation of nocturnal home haemodialysis, hospital haemodialysis and peritoneal dialysis, Nephrology Dialysis Transplantation. 2018.


Researcher : MA CY

List of Research Outputs

JIANG D., XIONG G., FENG H., ZHANG Z., Chen P., Yan B., CHEN L., Kesavamoorthy G., MA C.Y., Li C., HAN S., Zhang Y., Liao C., Lee T.L., Tse H.F., Fu Q.L., Chiu K. and Lian Q., Donation of mitochondria by iPSC-derived mesenchymal stem cells protects retinal ganglion cells against mitochondrial complex I defect-induced degeneration, Theranostics. Australia, Ivyspring International Publisher, 2019, 2019, Vol. 9, Issue 8: 2395-2410.


Researcher : Ma CH

Project Title:The role of calreticulin in normal hematopoiesis and myeloproliferative neoplasms
Investigator(s):Ma CH
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:03/2015


Project Title:Developing an in vivo zebrafish platform for functional evaluation of recurrent mutations in acute myeloid leukemia (AML) and primary screening of novel targeted therapeutic agents
Investigator(s):Ma CH, Leung AYH
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:05/2015


Project Title:Generating transgenic zebrafish model to study the emerging role of autophagy and mitophagy in hematopoietic diseases
Investigator(s):Ma CH, Leung AYH
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:05/2016




Researcher : Ma KFO

List of Research Outputs

Ma K.F.O., Ng C.L., Yick L.W., Jian M. and Chan K.H., In vivo electroporation-mediated transfer of interleukin-35 gene decreases demyelination in animal model of multiple sclerosis, 24th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2019, ;25(1)(Supplement 1): 32.
Ng C.L., Jian M., Bunting M., Ma K.F.O., Chung S.K. and Chan K.H., Adiponectin deficiency exacerbated neuropathologenesis and cognitive functions in Alzheimer’s disease mice: potential application of AdipoRon as Alzheimer’s disease treatment, 24th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2019, 25(1)(Supplement 1): 35.
Ng C.L., Jian M., Ma K.F.O. and Chan K.H., Adiponectin deficiency exacerbated vasculo-neuronal dysfunction and degeneration in Alzheimer’s disease mice model, 14th International Conference on Alzheimer's and Parkinson's Disease. 2019, Lisbon. 2019.


Researcher : Ma KMM

List of Research Outputs

Mok M.Y.M., Liu C.K., Lam M.F., Chan G.C., Ma K.M.M., Yap Y.H.D., Chiu F., Choy C.B., Tang S.C. and Chan D.T.M., A LONGITUDINAL STUDY ON THE PREVALENCE AND RISK FACTORS FOR DEPRESSION AND ANXIETY, QUALITY OF LIFE, AND CLINICAL OUTCOMES IN INCIDENT PERITONEAL DIALYSIS PATIENTS, Perit Dial Int.. 2018.
Yap Y.H.D., Tang S.O.C., Chan G.C.W., Kwan P.Y.L., Ma K.M.M., Mok M.Y. and Chan D.T.M., Longterm Data on Sirolimus Treatment in Patients with Lupus Nephritis, The Journal of Rheumatology. 2018, 45(12): 1663-1670.
Yap Y.H.D., Tam C.H., Yung S.S.Y., Wong S., Tang S.O.C., Mok M.Y.T., Yuen K.Y.C., Ma K.M.M., Lau W.C.S. and Chan D.T.M., Pharmacokinetics and pharmacogenomics of mycophenolic acid and its clinical correlations in maintenance immunosuppression for lupus nephritis, Nephrology Dialysis Transplantation. 2018.


Researcher : Mak JCW

Project Title:Role of transforming growth factor-beta1 variants in susceptibility to tuberculosis in Hong Kong Chinese population
Investigator(s):Mak JCW, Chan MMW
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:02/2005


Project Title:Therapeutic Potential of Human Induced Pluripotent Stem Cell-derived Mesenchymal Stem Cells (hiPSC-MSCs) on oxidative stress-induced
Investigator(s):Mak JCW
Department:Medicine
Source(s) of Funding:National Natural Science Foundation of China (NSFC) - General Program
Start Date:01/2014


Project Title:Role of Dendrobium officinale polysaccharides in amelioration of cigarette smoke-induced mucus hypersecretion – relevant to chronic obstructive pulmonary disease
Investigator(s):Mak JCW, Zhang Y
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:06/2017
Completion Date:09/2018


Project Title:Amelioration of cigarette smoke-induced mucus hypersecretion by Dendrobium officinale polysaccharides – relevant to chronic obstructive pulmonary disease
Investigator(s):Mak JCW, Zhang Y, Liang Y
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:04/2018


Project Title:Role of PM2.5 collected in Hong Kong on mitochondrial dynamics in airway epithelial cells
Investigator(s):Mak JCW, Liang Y, Tian L
Department:Medicine
Source(s) of Funding:Hong Kong Lung Foundation Research Grant
Start Date:07/2018


List of Research Outputs

Au Y.N.E., Liang Y., Ip M.S.M., Zhang Y. and Mak J.C.W., Effects of Dendrobium officinale Polysaccharides in Cigarette Smoke-induced Inflammation in Human Airway Epithelial NCI-H292 Cells, 24th Medical Research Conference, Department of Medicine, HKU, Hong Kong Medical Journal. Hong Kong Medical Jouranal, 2019, 25: 9.
CHEN R., Ip M.S.M. and Mak J.C.W., Effect of cigarette smoke on airway inflammation and mucus hypersecretion in submerged and well-differentiated airway epithelial cells, 24th Medical Research Conference, Department of Medicine, HKU. Hong Kong Medical Journal. 2019, 25 (Suppl 1): 11.
CHEN R., Yeung S.C., Ip M.S.M. and Mak J.C.W., The Role of ORMDL3 in Cigarette Smoke-induced Airway Injury, American Thoracic Society (ATS) and International Society of Respiratory Diseases (ISRD). 2019, 199: A3759.
CHEN R., Yeung S.C., Ip M.S.M. and Mak J.C.W., The role of ORMDL3 in cigarette smoke-induced airway injury, American Thoracic Society (ATS) International Conference 2019. 199: A3759.
Han Q., Yeung S.C., Ip M.S.M. and Mak J.C.W., Dysregulation of cardiac lipid parameters in high-fat high-cholesterol diet-induced rat model, Lipids Health Dis. 2018, 17: 255.
Lee Y.K.M., Ge M., Fung M.L., Vanhoutte P.M.G.R., Mak J.C.W. and Ip M.S.M., Low but not high frequency of intermittent hypoxia suppresses endothelium-dependent, oxidative stress-mediated contractions in carotid arteries of obese mice, Journal of Applied Physiology. 2018, 125: 1384-1395.
Liang Y., Ip M.S.M. and Mak J.C.W., (-)-Epigallocatechin-3-gallate suppresses cigarette smoke-induced inflammation in human cardiomyocytes via ROS-mediated MAPK and NF-κB pathways, Phytomedicine. 2019.
Liang Y., Ip M.S.M. and Mak J.C.W., Congress Bursary for 18th World Congress of Basic And Clinical Pharmacology (WCP2018), 18th World Congress of Basic And Clinical Pharmacology. 2018.
Liang Y., Ip M.S.M. and Mak J.C.W., Mito-TEMPO protects cardiomyocytes from cigarette smoke medium-induced inflammation and apoptosis in vitro, 18th World Congress of Basic And Clinical Pharmacology. 2018.
Liang Y., Tian L., Ho K.F., Ip M.S.M. and Mak J.C.W., Mitochondrial Toxicity of Fine Particulate Matter (PM2.5) Collected in Hong Kong in Human Airway Epithelial Cells, 24th Medical Research Conference, Department of Medicine, HKU, Hong Kong Medical Journal. Hong Kong Medical Journal, 2019, 25: 28.
Liang Y., Ip M.S.M. and Mak J.C.W., The Role of Mitochondria in Cigarette Smoke-induced Inflammation and Apoptosis in Cardiomyocytes, 22nd Annual Scientific Meeting of Institute of Cardiovascular Science and Medicine . Hong Kong, Journal of the Hong Kong College of Cardiology, 2018, 26: 108.
Lui M.S.M., Tse H.F., Mak J.C.W., Lam C.L.D., Chan W.S., Chong W.C. and Ip M.S.M., Untreated Obstructive Sleep Apnea Is Associated With Myocardial Injury Independent of Blood Pressure Control in Hypertension, Journal of Clinical Sleep Medicine. 2018, 14: 1841-1847.
WANG Y., Lee Y.K.M., Mak J.C.W. and Ip M.S.M., Low-Frequency Intermittent Hypoxia Suppresses Subcutaneous Adipogenesis and Induces Macrophage Polarization in Lean Mice, Diabetes Metab J. 2019.
Wong S.M., Lam W., Ge M., Yeung S.C., Liang Y., Ip M.S.M. and Mak J.C.W., Cardiac and Pulmonary Inflammatory Responses by Intermittent Hypoxia in C57BL/6N and C57BL/6J Mouse Strains, 24th Medical Research Conference, Department of Medicine, HKU, Hong Kong Medical Journal. 2019, 25: 32.
Yeung S.C., Ge M., Mak J.C.W. and Ip M.S.M., Differential effects of intermittent hypoxia on systemic and adipose tissue inflammation in lean and diet-induced obese mice, 24th Medical Research Conference, Department of Medicine, HKU, January 2019. Hong Kong Medical Journal. 2019, 25 (Suppl 1): 45.


Researcher : Mok MY

List of Research Outputs

Shea Y.F., Lee M.C., Mok M.Y., Lam M.F., Chu L.W., Chan H.W.F. and Chan D.T.M., Self-Care Peritoneal Dialysis Patients with Cognitive Impairment Have a Higher Risk of Peritonitis in the Second Year, Peritoneal Dialysis International. 2019, 39(1): 51-58.
Wong C.K.H., Chen J.Y., Fung S.K.S., Mok M.Y., Cheng Y.L., Kong I., Lo W.K., Lui S.L., Chan D.T.M. and Lam C.L.K., Direct and indirect costs of end-stage renal disease patients in the first and second years after initiation of nocturnal home haemodialysis, hospital haemodialysis and peritoneal dialysis, Nephrology Dialysis Transplantation. 2018.
Yap Y.H.D., Tang S.O.C., Chan G.C.W., Kwan P.Y.L., Ma K.M.M., Mok M.Y. and Chan D.T.M., Longterm Data on Sirolimus Treatment in Patients with Lupus Nephritis, The Journal of Rheumatology. 2018, 45(12): 1663-1670.


Researcher : Mok MYT

List of Research Outputs

Yap Y.H.D., Tam C.H., Yung S.S.Y., Wong S., Tang S.O.C., Mok M.Y.T., Yuen C.K.Y., Ma M.K.M., Lau W.C.S. and Chan D.T.M., Pharmacokinetics and pharmacogenomics of mycophenolic acid and its clinical correlations in maintenance immunosuppression for lupus nephritis, Nephrol Dial Transplant. 2018.
Yap Y.H.D., Tam C.H., Yung S.S.Y., Wong S., Tang S.O.C., Mok M.Y.T., Yuen K.Y.C., Ma K.M.M., Lau W.C.S. and Chan D.T.M., Pharmacokinetics and pharmacogenomics of mycophenolic acid and its clinical correlations in maintenance immunosuppression for lupus nephritis, Nephrology Dialysis Transplantation. 2018.


Researcher : NING Z

List of Research Outputs

Kwok H.H., NING Z., Chong W.C., Wan T.S.K., Ng M.H.L., Ho G.Y.F., Ip M.S.M. and Lam C.L.D., Transfer of Extracellular Vesicle-Associated-RNAs Induces Drug Resistance in ALK-Translocated Lung Adenocarcinoma, In: Prof. Samuel C. Mok, Cancers. Basel, Switzerland, MDPI, 2019, 11: 104.


Researcher : Ng CL

Project Title:Small molecule of Adiponectin receptor agonist, AdipoRon - a potential therapeutic medication for Alzheimer's disease
Investigator(s):Ng CL, Chan KH, Chung SK
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:07/2016
Completion Date:06/2019


Project Title:Disease Modeling and Phenotyping Drug testing of Alzheimer’s Disease by 3D culturing Patient-specific iPSC-derived neurons
Investigator(s):Ng CL, Chan KH
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research for New Staff
Start Date:01/2019


Project Title:The 14th International Conference on Alzheimer's & Parkinson's Diseases; ADIPONECTIN DEFICIENCY EXACERBATED VASCULO-NEURONAL DYSFUNCTION AND DEGENERATION IN ALZHEIMER’S MICE MODEL
Investigator(s):Ng CL
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:03/2019
Completion Date:03/2019


Project Title:Generation of of Nanobody Structure Corrector of Apolipoprotein E4: potential therapeutic tool for Alzheimer's disease
Investigator(s):Ng CL
Department:Medicine
Source(s) of Funding:Seed Fund for Translational and Applied Research
Start Date:06/2019


List of Research Outputs

JIAN M., Kwan S.C., Bunting M., Ng C.L. and Chan K.H., Adiponectin suppresses amyloid-beta oligomer (AbO)-induced inflammatory response of microglia via AdipoR1-AMPK-NF-kB signaling pathway, Journal of Neuroinflammation. 2019, 16: 110.
Jian M., Ng C.L. and Chan K.H., Adiponectin attenuates microglia-mediated neuroinflammation and modulates microglia phagocytosis in Alzheimer’s Disease, 14th International Conference on Alzheimer's & Parkinson's Diseases. 2019, Lisbon. 2019.
Ma K.F.O., Ng C.L., Yick L.W., Jian M. and Chan K.H., In vivo electroporation-mediated transfer of interleukin-35 gene decreases demyelination in animal model of multiple sclerosis, 24th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2019, ;25(1)(Supplement 1): 32.
Ng C.L., Jian M., Bunting M., Ma K.F.O., Chung S.K. and Chan K.H., Adiponectin deficiency exacerbated neuropathologenesis and cognitive functions in Alzheimer’s disease mice: potential application of AdipoRon as Alzheimer’s disease treatment, 24th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2019, 25(1)(Supplement 1): 35.
Ng C.L., Jian M., Ma K.F.O. and Chan K.H., Adiponectin deficiency exacerbated vasculo-neuronal dysfunction and degeneration in Alzheimer’s disease mice model, 14th International Conference on Alzheimer's and Parkinson's Disease. 2019, Lisbon. 2019.


Researcher : Ng KK

List of Research Outputs

Cheung Y.Y., Lee C.H.P., Tang S.M., Xu A., Au K.W., Fong H.Y., Ng K.K., KWOK H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Hai S.H.J.J., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Genetic regulation of Pigment Epithelium-Derived Factor (PEDF): an exome-chip association analysis in Chinese subjects with type 2 diabetes, Diabetes. 2019, 68: 198-206.


Researcher : Ng KM

Project Title:Novel Therapeutic Approach for X-linked related Danon Disease  Insight from Patient-specific Pluripotent Stem Cells Platform.
Investigator(s):Ng KM, Siu DCW, Tse HF
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2014


Project Title:Clinical Insight into Xi-chromosome Reactivation and its Therapeutic Potential in X-linked cardiomyopathies and related disorders.
Investigator(s):Ng KM, Tse HF
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2018


Project Title:Patient-specific isogenic iPSCs-derived cardiomyocytes as a clinically relevant platform for the identification of therapeutic targets for Rett syndrome
Investigator(s):Ng KM, Tse HF
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:04/2018


List of Research Outputs

Ng K.M., Lau V.Y.M., Vidhu D., Cai Z., Lee Y.K., Lai K.W.H., Tse H.F. and Siu D.C.W., Empagliflozin Ammeliorates High Glucose Induced-Cardiac Dysfuntion in Human iPSC-Derived Cardiomyocytes, Scientific Reports. 2018, 8.


Researcher : Pai MCP

List of Research Outputs

Li H., Chan Y.C., Cui D., Liu J.S., Wang M.C., Li N., Cheng S.W.K. and Pai M.C.P., Predictors of fistula maturation in a cohort of Chinese patients undergoing radiocephalic fistula creation, Dialysis Access Synergy (DASy), Singapore, 28-30 March 2019.
Li H., Chan Y.C., Cheng S.W.K. and Pai M.C.P., Successful endovascular treatment for a failing arteriovenous fistula, Dialysis Access Synergy (DASy), Singapore, 28-30 March 2019.


Researcher : Pan Y

List of Research Outputs

Pan Y., Hui X., Hoo R.L.C., Ye D., Chan C.Y.C., Feng T., Wang Y., Lam K.S.L. and Xu A., Adipocyte-secreted Exosomal Microrna-34a Inhibits M2 Macrophage Polarization To Promote Obesity-induced Adipose Inflammation, Journal of Clinical Investigation. 2019, 129: 834-849.


Researcher : Pang SYY

List of Research Outputs

Ho W.L., Leung C.T.G., Liu H., Pang S.Y.Y., Lam C.S.C., Xian J., Li L., Kung M.H.W., Ramsden D.B. and Ho S.L., Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA), Autophagy. 2019, 1-24.
LI T.H., Hui S.K., Chan Q., Yao N., Chua S.E., McAlonan G.M., Pang S.Y.Y., Ho S.L. and Mak H.K.F., Quantitative susceptibility mapping as an indicator of subcortical and limbic iron abnormality in Parkinson's disease with dementia, NeuroImage: Clinical. 2018.


Researcher : Ren T

List of Research Outputs

Ren T., Lyu M., An X., Xiao P., Lin Y. and Seto W.K.W., Abnormal expression and its role of adenosine A3 receptor in colonic mucosa epithelium of ulcerative colitis., 腺苷A3受体在溃疡性结肠炎患者结肠黏膜中的异常表达和作用, International Journal of Digestive Disease. 国际消化病杂志, 2018, 38: 407-412.
Ren T., Lv M., An X., Xiao P., Lin Y. and Seto W.K.W., Characteristics of altered 5-hydroxytryptamine signaling in colonic mucosa of patients with ulceratie colitis, 溃疡性结肠炎患者结肠黏膜5-HT信号通路的变化特点, International Journal of Digestive Diseases. 国际消化病杂志, 2019, 39: 222-227.


Researcher : SUN S

List of Research Outputs

Liao S., Zhang Y., Ting S.H.E.R.W.I.N., ZHEN Z., Luo F.A.N., Zhu Z., JIANG Y., SUN S., Lai K.W.H., Lian Q. and Tse H.F., Potent immunomodulation and angiogenic effects of mesenchymal stem cells versus cardiomyocytes derived from pluripotent stem cells for treatment of heart failure, Stem Cell Research & Therapy. 2019, 10.


Researcher : Seto WKW

Project Title:Provision of serum quantitative hepatitis B surface antigen measurements to optimize disease monitoring and risk stratification of chronic hepatitis B
Investigator(s):Seto WKW, Wong DKH, Fung JYY, Lai CL, Yuen RMF
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:12/2014
Completion Date:12/2018


Project Title:Metabolic determinants of fibrosis reversal in advanced chronic hepatitis B during long-term nucleoside analogue therapy
Investigator(s):Seto WKW, Lam KSL, Yuen RMF, Wong DKH, Fung JYY, Lee CHP
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2016


Project Title:Diabetes mellitus and liver fibrosis regression in nucleoside analogue-treated chronic hepatitis B: a prospective matched case-control evaluation using multiparametric magnetic resonance imaging and transient elastography
Investigator(s):Seto WKW, Chiu WHK, Lee CHP, Fung JYY, Yuen RMF
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:07/2017


Project Title:Outstanding Young Researcher Award 2016-17
Investigator(s):Seto WKW
Department:Medicine
Source(s) of Funding:Outstanding Young Researcher Award
Start Date:01/2018


Project Title:The interactive role of Paneth cells and the gut microbiota in a non-alcoholic fatty liver disease animal model
Investigator(s):Seto WKW, Yuen RMF, Wong DKH
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:04/2018


Project Title:Serum Enhanced Liver Fibrosis (ELF): A Validated Marker for the Non-invasive Diagnosis of Advanced Liver Fibrosis and Cirrhosis
Investigator(s):Seto WKW, Lee CHP, Yuen MAM, Wong DKH, Yuen RMF
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:06/2018


Project Title:Bile acid dysmetabolism as a potential mediator for gut microbiota to induce nonalcoholic fatty liver disease
Investigator(s):Seto WKW, Wong DKH, Yuen RMF
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:05/2019


Project Title:An Artificial Intelligence System For The Detection And Characterization Of Early Liver Cancer
Investigator(s):Seto WKW, Chiu WHK, Yu PLH, Li WK, Yuen RMF
Department:Medicine
Source(s) of Funding:Innovation and Technology Support Programme (Tier 2)
Start Date:05/2019


Project Title:An Artificial Intelligence System For The Detection And Characterization Of Early Liver Cancer
Investigator(s):Seto WKW, Chiu WHK, Yu PLH, Li WK, Yuen RMF
Department:Medicine
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:05/2019


Project Title:An Artificial Intelligence System For The Detection And Characterization Of Early Liver Cancer
Investigator(s):Seto WKW, Chiu WHK, Yu PLH, Li WK, Yuen RMF
Department:Medicine
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:05/2019


List of Research Outputs

CHEN Y., Liu Y., Seto W.K.W., Wu M., YU Y., Lam Y.M., Au W.K., Chan D., Sit K.Y., Ho L.M., Tse H.F. and Yiu K.H., Prognostic Value of Hepatorenal Function By Modified Model for End‐stage Liver Disease (MELD) Score in Patients Undergoing Tricuspid Annuloplasty, Journal of the American Heart Association. 2018, 7: e009020.
Chan H.L.Y., Lim Y., Seto W.K.W., Agarwal K., Brunetto M.R., Janssen H.L., Caruntu F., Stepanova T., Tsang O. and Yatsuhashi H., Three Year Efficacy and Safety of Tenofovir Alafenamide (TAF) Compared to Tenofovir Disoproxil Fumarate (TDF) in Hbeag-Negative and Hbeag-Positive Patients with Chronic Hepatitis B, HEPATOLOGY. WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2018, 68: 227A-228A.
Chen Y., Liu Y., Seto W.K.W., Wu M., YU Y., Lam Y.M., Au T.W.K., Sit K.Y., Ho L.M., Tse H.F. and Yiu K.H., Prognostic Value of Hepatorenal Function By Modified Model for End-stage Liver Disease (MELD) Score in Patients Undergoing Tricuspid Annuloplasty, Journal of the American Heart Association. 2018, 7(14): 1-11.
Cheung K.S.M., Leung W.K. and Seto W.K.W., Application of Big Data analysis in gastrointestinal research, World Journal of Gastroenterology. 2019, 25: 2990-3008.
Cheung K.S.M., Chen L., Seto W.K.W. and Leung W.K., Best Abstract Award in Clinical Medicine (oral presentation), 24th Medical Research Conference, Hong Kong, The University of Hong Kong . 2019.
Cheung K.S.M., Chen L., Seto W.K.W. and Leung W.K., Epidemiology, characteristics and survival of post-colonoscopy colorectal cancer in Hong Kong: a population-based study, Medical Research Conference. 2019.
Cheung K.S.M., Chen L., Seto W.K.W. and Leung W.K., Epidemiology, characteristics and survival of post‐colonoscopy colorectal cancer in Asia: a population‐based study, Journal of Gastroenterology and Hepatology. 2019.
Cheung K.S.M., Chan E.W., Wong A.Y., Chen L., Seto W.K.W., Wong I.C.K. and Leung W.K., Metformin Use and Gastric Cancer Risk in Diabetic Patients After Helicobacter pylori Eradication, JNCI: Journal of the National Cancer Institute. 2018.
Cheung K.S.M., Chan E.W.Y., Wong A.S.Y., Chen L., Seto W.K.W., Wong I.C.K. and Leung W.K., Statin use and gastric cancer risk in Helicobacter pylori-eradicated patients: a territory-wide study with propensity score matching, Medical Research Conference, Hong Kong. 2019.
Cheung K.S.M., Chen L., Chan E.W., Seto W.K.W., Wong I.C.K. and Leung W.K., Statins reduce the progression of non-advanced adenomas to colorectal cancer: a postcolonoscopy study in 187 897 patients, Gut. 2019, gutjnl-2018-317714.
Cheung K.S.M., Chan E.W.Y., Chen L., Seto W.K.W., Wong I.C.K. and Leung W.K., Use of non-aspirin non-steroidal anti-inflammatory drugs and risk of post-colonoscopy colorectal cancer: a territory-wide study with propensity score analysis, Digestive Disease Week . 2019.
Fung J.Y.Y., Chok K.S.H., Chan A.C.Y., Dai W.C., She W.H., Sin S.L., Ma K.W., Ng K.C.K., Wong C.L.T., Cheung T.T., Seto W.K.W., Lai C.L., Lo C.M. and Yuen R.M.F., High Predictive value of MELD for short-term mortality in severe acute flares of chronic hepatitis B, Hepatology. 2018, 68: 1211A-1211A.
Fung J.Y.Y., Wong D.K.H., Tanaka Y., Lo C.L.R., Wong C.L.T., Chok K.S.H., Chan A.C.Y., Cheung T.T., Dai W.C., Ng K.C.K., Ng K.T.P., Man K., Ng I.O.L., Seto W.K.W., Lai C.L., Yuen R.M.F. and Lo C.M., Quantitative hepatitis B surface antigen in predicting recurrence of hepatitis B-related hepatocellular carcinoma after liver transplantation, Hepatoma Research. 2018, 4: 62.
Fung J.Y.Y., Chok K.S.H., Wong C.L.T., Dai W.C., Chan A.C.Y., Sin S.L., She W.H., Ma K.W., Ng K.C.K., Seto W.K.W., Yuen R.M.F. and Lo C.M., Risk Factors for Graft Steatosis after Liver Transplantation using Controlled Attenuation Parameter Measurements, Transplantation. 2018, 102: S863.
Hung F.N.I., Wong D.K.H., Seto W.K.W., Fung J.Y.Y., Yuen K.Y. and Yuen R.M.F., A Double-Blind Randomized Controlled Trial of Intradermal Hepatitis B Vaccination with Topical Imiquimod in Subjects with Occult Hepatitis B Infection, HEPATOLOGY. WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2018, 68: 255A-256A.
Ko K.L., To W.P., Mak L.Y., Seto W.K.W., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., A Large Cohort Study Examining the Effects of Long-Term Entecavir on Hepatocellular Carcinoma and HBsAg Seroclearance, HEPATOLOGY. WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2018, 68: 260A-260A.
LIU F., ZHANG S., Huang F.Y., Wong D.K.H., Mak L.Y., Cheung K.S.M., Lai C.L., Yuen R.M.F. and Seto W.K.W., Characterization of regulatory T cells and the role of PD-1 and TNF-alpha in spontaneous hepatitis B surface antigen seroclearance in chronic hepatitis B, JOURNAL OF HEPATOLOGY. ELSEVIER SCIENCE BV PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, 2019, 70: E454-E455.
LIU F., ZHANG S., Huang F.Y., Wong D.K.H., Mak L.Y., Cheung K.S.M., Lai C.L., Yuen R.M.F. and Seto W.K.W., Characterization of regulatory T cells and the role of PD-1 and TNF-alpha in spontaneous hepatitis B surface antigen seroclearance in chronic hepatitis B, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2019, 701: E454-455.
LIU F., Seto W.K.W., Wong D.K.H., Huang F.Y., Cheung K.S.M., Mak L.Y., Sharma R., ZHANG S., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Plasma fibronectin levels identified via quantitative proteomics profiling predicts hepatitis B surface antigen seroclearance in chronic hepatitis B, The Journal of Infectious Diseases. 2019, 220(6): 940-950.
Lam Y.F., Seto W.K.W., Tong S.M., Cheung K.S.M., Lo O.S.H., Hung F.N.I., Law W.L. and Leung W.K., Rates of metachronous adenoma after curative resection for left-sided or right-sided colon cancer, Intestinal Research. 2018, 16: 619-627.
Leung W.K., Chen L., Seto W.K.W. and Cheung K.S.M., Characteristics and risk factors of post-colonoscopy interval cancers: a population-based study from Asia, Digestive Disease Week. 2019.
Li Q., Xiao P., Ling T., Sun Y., Luo L., Liang R., Deng Z. and Seto W.K.W., Detection of proximal serrated polyps: a single-center retrospective analysis, 近端锯齿状息肉检出的单中心回顾性研究, Chinese Journal of Digestive Endoscopy. 中华消化内镜杂志, 2019, 36: 86-90.
Liu F., Seto W.K.W., Wong D.K.H., Huang F.Y., Mak L.Y., Cheung K.S.M., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Serum Fibronectin Levels Identified Via Proteomics Profiling Predict Spontaneous Hepatitis B Surface Antigen Seroclearance in Chronic Hepatitis B, HEPATOLOGY. WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2018, 68: 1185A-1186A.
Liu S.H.K., Seto W.K.W., Lau E.H.Y., Wong D.K.H., Lam Y.F., Cheung K.S.M., Mak L.Y., Ko K.L., To W.P., Law M.W.K., Wu J.T.K., Lai C.L. and Yuen R.M.F., A territory-wide prevalence study on blood-borne and enteric viral hepatitis in Hong Kong, The Journal of Infectious Diseases. 2019, 219(12): 1924-1933.
Ma H.C.J., Mak L.Y., Cheung K.S.M., Fung J.Y.Y., Lai C.L., Yuen R.M.F. and Seto W.K.W., Concomitant diabetes mellitus increases risk of liver fibrosis in treatment-naive chronic hepatitis B with low viral loads: Results from a matched case-control study, JOURNAL OF HEPATOLOGY. ELSEVIER SCIENCE BV PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, 2019, 70: E264-E264.
Mak L.Y., Lee C.H.P., Cheung K.S.M., Wong D.K.H., LIU F., Hui R.W., Fung J.Y.Y., Xu A., Lam K.S.L., Yuen R.M.F. and Seto W.K.W., Association of adipokines with hepatic steatosis and fibrosis in chronic hepatitis B patients on long‐term nucleoside analogue, Liver International. 2019, 39(7): 1217-1225.
Mak L.Y., Wong D.K.H., Seto W.K.W., Ning Q., Cheung K.S.M., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Correlation of serum Mac-2-binding protein glycosylation isomer (M2BPGi) and liver stiffness in chronic hepatitis B infection, Hepatology International. 2019, 13(2): 148-156.
Mak L.Y., Seto W.K.W., Hui R.W., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Fibrosis evolution in chronic hepatitis B E‐antigen negative patients across a 10‐year interval, Journal of Viral Hepatitis. 2019, 26(7): 818-827.
Mak L.Y., Wong D.K.H., Seto W.K.W., Cheung K.S.M., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., High Serum Mac-2-binding protein glycosylation isomer (M2BPGi) level was associated with incident hepatocellular carcinoma in entecavir-treated chronic hepatitis B patients, Hepatology. 2018, 68: 864A-864A.
Mak L.Y., Seto W.K.W., Fung J.Y.Y. and Yuen R.M.F., New Biomarkers of Chronic Hepatitis B, Gut and Liver. 2019.
Mak L.Y., Seto W.K.W., Fung J.Y.Y. and Yuen R.M.F., Novel developments of hepatitis B: treatment goals, agents and monitoring tools, Expert Review of Clinical Pharmacology. 2019, 12(2): 109-120.
Mak L.Y., To W.P., Wong D.K.H., Fung J.Y.Y., LIU F., Seto W.K.W., Lai C.L. and Yuen R.M.F., Serum Mac-2 binding protein glycosylation isomer level predicts hepatocellular carcinoma development in E-negative chronic hepatitis B patients, World Journal of Gastroenterology. 2019, 25: 1398-1408.
Mak L.Y., Ko M., To E., Wong D.K.H., Ma J.H.C., Hui T.L.Y., Seto W.K.W., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Serum Mac-2-binding protein glycosylation isomer and risk of hepatocellular carcinoma in entecavir-treated chronic hepatitis B patients, Journal of Gastroenterology and Hepatology. 2019.
Ren T., Lyu M., An X., Xiao P., Lin Y. and Seto W.K.W., Abnormal expression and its role of adenosine A3 receptor in colonic mucosa epithelium of ulcerative colitis., 腺苷A3受体在溃疡性结肠炎患者结肠黏膜中的异常表达和作用, International Journal of Digestive Disease. 国际消化病杂志, 2018, 38: 407-412.
Ren T., Lv M., An X., Xiao P., Lin Y. and Seto W.K.W., Characteristics of altered 5-hydroxytryptamine signaling in colonic mucosa of patients with ulceratie colitis, 溃疡性结肠炎患者结肠黏膜5-HT信号通路的变化特点, International Journal of Digestive Diseases. 国际消化病杂志, 2019, 39: 222-227.
Seto W.K.W., 2030: Is eradication of viral hepatitis possible?, Hong Kong Association for the Study of Liver Disease Symposium. 2019.
Seto W.K.W., Asia Pacific Disease Week Emerging Leader 2018, Asia Pacific Disease Week Federation. 2018.
Seto W.K.W., Buti M., Izumi N., Lim Y., Kao J., Streinu-Cercel A., Nurmukhametova E., Ma X., Tabak F. and Jablkowski M., Bone and Renal Safety Are Improved in Chronic HBV Patients 1 Year after Switching to Tenofovir Alafenamide (TAF) from Tenofovir Disoproxil Fumarate (TDF), HEPATOLOGY. WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2018, 68: 240A-241A.
Seto W.K.W., Bone and renal safety Are improved in chronic HBV patients switched to tenofovir alafenamide after either 2 or 3 years of prior tenofovir disoproxil fumarate treatment., Liver Week, Korean Association for the Study of the Liver. 2019.
Seto W.K.W., Chronic hepatitis B and metabolic risk factors: A call for rigorous longitudinal studies, World Journal of Gastroenterology. 2019, 25: 282-286.
Seto W.K.W., Lo Y.R., Pawlotsky J.M. and Yuen R.M.F., Chronic hepatitis B virus infection, The Lancet. 2018, 392: 2313-2324.
Seto W.K.W., HCV Infection: Towards Eradication. Asia-Pacific Conference in Clinical Microbiology and Infection, 2018.
Seto W.K.W., HEV, HCV, HBV and the Occult, Hong Kong Blood Transfusion Service Lecture. 2019.
Seto W.K.W. and Yuen R.M.F., Hepatitis B Virus: Asian Perspective, In: Wong, Robert J. and Gish, Robert G., Clinical Epidemiology of Chronic Liver Diseases. Cham, Springer International Publishing, 2019, 99-116.
Seto W.K.W., Incidence and clinical characteristics of hepatocellular carcinoma in chronic hepatitis B patients treated for up to 4 years with tenofovir alafenamide or tenofovir disoproxil fumarate in 2 large phase 3 studies., Annual Conference, China Network for Severe Liver Disease, Suzhou, China 2019.
Seto W.K.W., Intestinal microbiota, metabolomics and liver disease: Is it you or your bacteria?, 25th Anniversary Congress of the Hong Kong Academy of Medicine. 2018.
Seto W.K.W., Management of occult hepatitis B infection, Beijing / Hong Kong Medical Exchange Conference, Hong Kong Medical Association.. 2018.
Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Mak L.Y., Wong D.K.H., Fung J.Y.Y., Liu S.H.K., Cheung K.S.M., Lai C.L., Kwong Y.L. and Yuen R.M.F., Monitoring and Treatment of Patients Undergoing Immunotherapy With Anti-CD20 Who are Exposed to HBV, Clinical Gastroenterology and Hepatology. 2018, 17(7): 1410-1412.
Seto W.K.W., New horizon for chronic hepatitis B management, Liver Week Satellite Symposium, Korean Association for the Study of the Liver, Busan, Korea. 2019.
Seto W.K.W., Occult hepatitis B and C: implications for blood safety, Annual Congress of the Korean Society of Blood Transfusion, Daegu, Korea. 2019.
Seto W.K.W., Occult hepatitis B infection, Hong Kong College of Physicians Annual Scientific Meeting. 2018.
Seto W.K.W., Recent advances in the diagnosis and therapy of liver fibrosis and cirrhosis, Dongguan Gastroenterology Conference, Donggguan, China. 2018.
Seto W.K.W., The functional cure of chronic hepatitis B, China Southern Hepatitis Medical Symposium, Guangzhou, China. 2018.
Seto W.K.W., Liu S.H.K., Mak L.Y., Cheung K.S.M., Wong D.K.H., Liu F., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Treatment Cessation in Chronic Hepatitis B: Predicting Off-Treatment Durability Via Combination of Viral Markers, HEPATOLOGY. WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2018, 68: 248A-249A.
Wong D.K.H., Cheng C.Y.S., Mak L.Y., To W.P., Lo C.L.R., Cheung T.T., Seto W.K.W., Fung J.Y.Y., Man K., Lai C.L. and Yuen R.M.F., Among Patients with Undetectable Hepatitis B Surface Antigen and Hepatocellular Carcinoma, a High Proportion Has Integration of HBV DNA into Hepatocyte DNA and No Cirrhosis, Clinical Gastroenterology and Hepatology. 2019.
Wong D.K.H., Cheng C.Y.S., Mak L.Y., To W.P., Cheung T.T., Seto W.K.W., Fung J.Y.Y., Man K., Lai C.L. and Yuen R.M.F., High Rate of HBV DNA Integration in Hepatocellular Carcinoma Patients with Occult Hepatitis B Infection, HEPATOLOGY. WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2018, 68: 331A-331A.
Wong D.K.H., Cheng C.Y.S., Mak L.Y., To W.P., Cheung T.T., Seto W.K.W., Fung J.Y.Y., Man K., Lai C.L. and Yuen R.M.F., Integration of HBV DNA near cancer-related genes in HBsAg-negative hepatocellular carcinoma patients, JOURNAL OF HEPATOLOGY. ELSEVIER SCIENCE BV PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, 2019, 70: E269-E269.
Wong D.K.H., Cheng C.Y.S., Mak L.Y., To W.P., Cheung T.T., Seto W.K.W., Fung J.Y.Y., Man K., Lai C.L. and Yuen R.M.F., Integration of HBV DNA near cancer-related genes in HBsAg-negative hepatocellular carcinoma patients, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2019, 701: E269.
Yuen R.M.F., Liu S.H.K., Seto W.K.W., Wong D.K.H., Wong S.Y., Cheung K.S.M., Mak L.Y.L., Ko K.L.M., To W.P.E., Yuen J.C.H., Wu C.H., Cheng C.T.K., Wu J.T.K. and Lau E.H.Y., Faculty Knowledge Exchange Award, HKU LKS Faculty of Medicine. 2019.
ZHANG S., LIU F., Huang F.Y., Wong D.K.H., Lai C.L., Yuen R.M.F. and Seto W.K.W., The role of Paneth cells in the pathogenesis of non-alcoholic fatty liver disease: A potential gut microbiota-associated mechanism, JOURNAL OF HEPATOLOGY. ELSEVIER SCIENCE BV PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, 2019, 70: E553-E553.


Researcher : Shea YF

List of Research Outputs

Shea Y.F., Lee M.C., Mok M.Y., Lam M.F., Chu L.W., Chan H.W.F. and Chan D.T.M., Self-Care Peritoneal Dialysis Patients with Cognitive Impairment Have a Higher Risk of Peritonitis in the Second Year, Peritoneal Dialysis International. 2019, 39(1): 51-58.


Researcher : Shek YNS

List of Research Outputs

Chan W.M.M., Shek Y.N.S., Yeung C.K. and Chan H.L.H., A prospective study in the treatment of lentigines in Asian skin using 532 nm picosecond Nd: YAG laser. , In: Brian Wong, Lasers in Surgery and Medicine. Lasers in Surgery and Medicine, 2019.


Researcher : Shen J

Project Title:Biochemical Society Meeting 679 University of Essex UK - Stress, Signalling and Control Reactive Oxygen Species Mediate Intracellular Cholesterol Accumulation via Modulating Caveolin-1 Pathway in Chinese Hamster Ovary Cells
Investigator(s):Shen J
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:07/2003


Project Title:Elucidating peroxynitrite as a cellular signaling molecule for regulating neurogenesis under hypoxic and ischemic conditions
Investigator(s):Shen J, Yang D, Chen X
Department:School of Chinese Medicine
Source(s) of Funding:National Natural Science Foundation of China (NSFC) - General Program
Start Date:01/2013


Project Title:Exploring HMGB1 signaling as molecular target in peroxynitrite-mediated blood brain barrier disruption and hemorrhage transformation in ischemia-reperfused brain with delayed thrombolytic therapy
Investigator(s):Shen J, Yang D, Chung SK
Department:School of Chinese Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2015
Completion Date:09/2018


Project Title:Elucidating Impacts of Reactive Nitrogen Species-mediated Excessive Mitophagy on Cerebral Ischemic-Reperfusion Injury and Exploring the Neuroprotective Mechanisms of Naringin for Inhibition of Excessive Mitophagy
Investigator(s):Shen J, Chen X
Department:School of Chinese Medicine
Source(s) of Funding:National Natural Science Foundation of China (NSFC) - General Program
Start Date:01/2016


Project Title:Exploring Effects of Glycyrrhizin, an Active Compound from Glycyrrhizae Radix, on Attenuating Delayed Tissue-plasminogen Activator (t-PA) Treatment-induced Hemorrhagic Transformation in Ischemic Stroke
Investigator(s):Shen J, Chen X, Fung ML, Chen H
Department:School of Chinese Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:05/2016
Completion Date:06/2019


Project Title:Evaluating the neuroprotective effect and safety of An-Gong-Niu-Huang Wan and its ingredients in ischemic stroke
Investigator(s):Shen J
Department:School of Chinese Medicine
Source(s) of Funding:Matching Grant for Joint Research
Start Date:06/2016


Project Title:Exploring Molecular Targets for Drug Discovery to Preventing Hyperglycemia-mediated Hemorrhagic transformation in Ischemic Stroke: Sodium Danshensu (SDSS) as an Example
Investigator(s):Shen J, Siu DCW, Chung SK
Department:School of Chinese Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:09/2017


Project Title:Elucidating the roles of caveolin-1, a major component of mitochondria-associated-membrane, in regulating adult hippocampal neurogenesis and ageing
Investigator(s):Shen J
Department:School of Chinese Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:06/2019




Researcher : Shiu SWM

List of Research Outputs

Tan K.C.B., Cheung C.L., Lee C.H.A., Lam J.K.Y., Wong Y. and Shiu S.W.M., Galectin-3 and risk of cardiovascular events and all-cause mortality in type 2 diabetes, Diabetes Metab Res Rev. 2019, 35(2): e3093.


Researcher : Shu L

Project Title:Fatty acid binding protein 4 as a therapeutic target for atherosclerosis by regulating gut microbiota and immunity
Investigator(s):Shu L, Hoo RLC, Xu A
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:04/2019


List of Research Outputs

CHEONG L.Y., Wang B., Shu L., WU X., Hoo R.L.C. and Xu A., Absence of inguinal lymph nodes impairs the browning of subcutaneous white adipose tissue in mice , 2018 FASEB Science Research Conferences - Immunological Aspects of Metabolic Syndrome . 2018.
CHEONG L.Y., Wang B., Shu L., Wu X., Hoo R.L.C. and Xu A., Absence of inguinal lymph nodes impairs the browning of subcutaneous white adipose tissue in mice, FASEB Science Research Conferences, 10-15 Aug 2018, Snowmass, CO. 2018.
Shu L., WU X., CHEONG L.Y., Zhou Z., Hoo R.L.C., Lam K.S.L. and Xu A., FABP4 mediates autoimmune destruction of beta cells by enhancing the crosstalk between innate and adaptive immunity/ Oral presentation, Asia Islet Biology and Incretin Symposium (AIBIS 2018). 2018.
Shu L., Hoo R.L.C. and Xu A., Fabp4 Mediates Autoimmune Diabetes Though Activation On Macrophage And Tissue Resident Memory T Lymphocyte , Shs Young Investigator Symposium & 9th Gwanak Symposium. 2019.
Shu L., Hoo R.L.C. and Xu A., Fabp4 Promotes Autoimmune Diabetes Through Activation On Macrophages And Tissue Resident Memory T Lymphocytes, Shs Young Investigator Symposium. 2019.
Shu L., Hoo R.L.C. and Xu A., Fabp4 Promotes Autoimmune Diabetes Through Activation On Macrophages And Tissue Resident Memory T Lymphocytes, Shs Young Investigator Symposium & Gwanak Symposium. 2019.


Researcher : Sim PYJ

List of Research Outputs

Kwok W.C., Liang B.M., Lui M.S.M., Tam C.C.T., Sim P.Y.J., Tse E.W.C., Leung A.Y.H., Kwong Y.L., Lie A.K.W., Ip M.S.M. and Lam C.L.D., Rapid versus gradual lung function decline in bronchiolitis obliterans syndrome after haematopoietic stem cell transplantation is associated with survival outcome, Respirology. 2019, 24: 459-466.


Researcher : Sin WC

List of Research Outputs

Sin W.C., Yeung P.N.P., Ngai C.W., Lai C.K.P., Chan W.K.R. and Mok Y.T.A., Education Curriculum on Extracoporeal Membrane Oxygenation – the Evolving Role of Simulation Training. , Advances in Extra-corporeal Perfusion Therapies. IntechOpen, 2019.
Sin W.C., Yeung P.N.P., Ngai W.C.W., Lai P.C.K., Mok A.Y.T. and Chan R.W.K., Simulation training for crises during venoarterial extracorporeal membrane oxygenation, Journal of Thoracic Disease. 2019, 11: 2144-2152.
Tsai N.W.P., Leung Y.M., Yeung P.N.P., Liong T.I.N.G., Lee S.F., Ngai C.W., Sin W.C., Koo J. and Chan W.M., Attitudes of visitors at adult intensive care unit toward organ donation and organ support, Chinese Medical Journal. 2019, 132: 373-376.


Researcher : Singh GHH

Project Title:Mechanisms of leukaemic transformation from myelodysplastic syndromes (MDS) failing treatment with demethylating agents.
Investigator(s):Singh GHH, Kwong YL, Leung AYH
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2015


Project Title:Significance of novel mutations detected by serial whole exome sequencing in relapsed or refractory acute promyelocytic leukaemia resistant to arsenic trioxide
Investigator(s):Singh GHH
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:01/2017


Project Title:Clinical and genomic registry of myelodysplastic syndrome (MIDS) and secondary acute myeloid leukaemia (AML) in Asia
Investigator(s):Singh GHH, Kwong YL
Department:Medicine
Source(s) of Funding:Celgene International II SARL
Start Date:01/2019


List of Research Outputs

Singh G.H.H., Ip H.W., Yim R.L.H., Tang W.F., Pang H.M.H., Lee P., Leung G.M.K., Li J.W.Y., Tang K., So J.C.C., Leung R.Y.Y., Li J., Panagiotou I., Lam C.C.K. and Kwong Y.L., Next-generation sequencing with a 54-gene panel identified unique mutational profile and prognostic markers in Chinese patients with myelofibrosis, Annals of Hematology. 2018.
Singh G.H.H., Kumana C.R. and Kwong Y.L., Oral Arsenic Trioxide in the Frontline Treatment of Newly-Diagnosed Acute Promyelocytic Leukemia: A 5-Year Prospective Cohort Study, Blood. 2018, 132: 390.
Singh G.H.H., Kumana C.R., Yim R.L.H., Hwang Y.Y.G., Chan S.Y.T., Yip S.F., Lee H.K.K., Mak V., Lau J.S.M., Chan C.C., Kho B., Wong R.S.M., Li W., Lin S.Y., Lau C.K., Ip H.W., Leung R.Y.Y., Lam C.C.K. and Kwong Y.L., Oral arsenic trioxide incorporation into frontline treatment with all‐trans retinoic acid and chemotherapy in newly diagnosed acute promyelocytic leukemia: A 5‐year prospective study, Cancer. 2019.


Researcher : Siu DCW

Project Title:Dynamic Conformational Changes of the P-S6 linker of the Pacemaker (HCN) Channels Identified by Sulfhydryl Modification: Pore-to-Gate Coupling Model
Investigator(s):Siu DCW, Tse HF
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:10/2008


Project Title:Fabrication of Bio-artificial Atrio-Ventricular Node for Biological Pacing combining 3D Bio-printing and Induced Pluripotent Stem Cell Technology
Investigator(s):Siu DCW
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2017


Project Title:Territory-wide pulmonary hypertension screening amongst partients with connective tissue diseases: A prospective screening study
Investigator(s):Siu DCW
Department:Medicine
Source(s) of Funding:Actelion Pharmaceuticals Hong Kong Limited
Start Date:09/2017


Project Title:Research on Diabetes and Cardiovascular Area and Relevant Publication
Investigator(s):Siu DCW
Department:Medicine
Source(s) of Funding:AstraZeneca Hong Kong Ltd
Start Date:02/2018


List of Research Outputs

BLAIS J.E., Chan E.W.Y., Law W.Y., Mok M.T., Huang D., Wong I.C.K. and Siu D.C.W., Trends in statin prescription prevalence, initiation, and dosing: Hong Kong, 2004–2015, Atherosclerosis. 2018, 280: 174-182.
Chan M.L., Cheung C.L., Lee C.H.A., Yeung C.Y., Siu D.C.W., Leung J.Y., Pang H.K. and Tan K.C.B., Genetic variations in familial hypercholesterolemia and cascade screening in East Asians, Mol Genet Genomic Med. 2019, 7(2): e00520.
Chan N.Y., Choy C.C., Chan C.K. and Siu D.C.W., Effectiveness of a nongovernmental organization-led large-scale community atrial fibrillation screening program using the smartphone electrocardiogram: An observational cohort study., Heart Rhythm. 2018. 2018, 15(9): 1306-1311.
Hai S.H.J.J., Fang J., Tam C.C., Wong C.K., Un C.K., Siu D.C.W., Lau C.P. and Tse H.F., Safety and feasibility of a midseptal implantation technique of a leadless pacemaker, Heart Rhythm. 2019, 16: 896-902.
Huang D., Cheng Y., Wong Y.T.A., Yung S.A., Tam C.C., Chan K.W.K., Lam C.C.S., Yiu K.H., Hai S.H.J.J., Lau C.P., Chan E.W.Y., Chiang C.E., Wong K.L., Cheung T.T., Cheung B.M.Y., Feng Y.Q., Tam N., Chen J.Y., Yue W.S., Hu H.X., Chen L., Tse H.F., Chan P.H.M. and Siu D.C.W., Thrombolysis in myocardial infarction risk score for secondary prevention of recurrent cardiovascular events in a real-world cohort of post-acute myocardial infarction patients, Circulation. 2019, 83(4): 809-817.
Lau C.P., Hai S.H.J.J. and Siu D.C.W., Implantable cardioverter defibrillators in Asian population, Pacing and Clinical Electrophysiology. 2018, 41: 1627-1629.
Law W.Y., Lau C.Y., Wong I.C.K., Lip G.Y.H., Mok M.T., Siu D.C.W. and Chan E.W., Sex-based differences in outcomes of oral anticoagulation in patients with atrial fibrillation, Journal of the American College of Cardiology. 2018, 72: 271-282.
Ng K.M., Lau V.Y.M., Vidhu D., Cai Z., Lee Y.K., Lai K.W.H., Tse H.F. and Siu D.C.W., Empagliflozin Ammeliorates High Glucose Induced-Cardiac Dysfuntion in Human iPSC-Derived Cardiomyocytes, Scientific Reports. 2018, 8.
Siu D.C.W., 2019 Invited Speaker, 61th Annual International Symposium on CIED Infection and Treatment Beijing, “Clinical application on SICD in Asia Pacific, 2019.
Siu D.C.W., Invited Speaker, APHRS 2018 Bangkok, Thailand, “ Insight from RCT and RWE: Answering the unanswer”, 2018.
Siu D.C.W., Invited Speaker, BI Lecture Tour in Dalian, Beijing, Tianjin, China , “亚洲房颤患者抗凝药物抉择” “NOAC真实世界研究”, 2018.
Siu D.C.W., Invited Speaker, “2018南充市超聲醫學質控制中心, 第一屆川東北國際超聲學術研討會 “Futuristic Approach for Heart Failure Management”, 2018.
Siu D.C.W., Invited Speaker, 亞洲心臟病醫院學術年會2018, “Hereditary Premature Cardiac Aging, 2018.
Tomlinson B., Chan J.C., Chan W.B., Chen W.W., Chow F.C., Li S.K., Kong A.P., Ma R.C., Siu D.C.W., Tan K.C.B., Wong L.K., Yeung V.T., But B.W., Cheung P.T., Fu C.C., Tung J.Y., Wong W.C. and Yau H.C., Guidance on the management of familial hypercholesterolaemia in Hong Kong: an expert panel consensus viewpoint., Hong Kong Medical Journal. Hong Kong, Hong Kong Academy of Medicine, 2018, 24(4): 408–15.


Researcher : Siu SC

List of Research Outputs

Wong C.K.H., Siu S.C., Wong K.W., Yu Y.T.E. and Lam C.L.K., Five-year effectiveness of short messaging service (SMS) for pre-diabetes, BMC Research Notes. 2018, 11: 709.


Researcher : TSOI MF

List of Research Outputs

Chan S.L.Y., TSOI M.F., Cheung T.T. and Cheung B.M.Y., Stroke incidence in Hong Kong after recall of contaminated generic valsartan, 24th Medical Research Conference. Hong Kong, Hong Kong Medical Journal, 2019, 25 (1), supp 1: 9.
Cheung T.T., TSOI M.F., Cheung B.M.Y. and Lau W.C.S., Mortality and causes of death in inflammatory arthritis patients in Hong Kong 1997-2016, 24th Medical Research Conference. Hong Kong, Hong Kong Medical Journal, 2019, 25 (1), supp 1: 13.
FEI Y., TSOI M.F. and Cheung B.M.Y., Cardiovascular outcomes in trials of new antidiabetic drug classes: a network meta-analysis, 24th Medical Research Conference. Hong Kong, Hong Kong Medical Journal, 2019, 25 (1), supp 1: 17.
FEI Y., TSOI M.F. and Cheung B.M.Y., Determining the Optimal Systolic Blood Pressure for Hypertensive Patients: A Network Meta-analysis, Canadian Journal of Cardiology. 2018, 34: 1581-1589.
FEI Y., TSOI M.F. and Cheung B.M.Y., Optimal duration of dual antiplatelet therapy after drug-eluting stent implantation: a network meta-analysis, 24th Medical Research Conference. Hong Kong, Hong Kong Medical Journal, 2019, 25 (1), supp 1: 18.
Lui K.W.K., TSOI M.F., Cheung T.T., Cheung C.L. and Cheung B.M.Y., Are blood lead levels in the United States still declining? The United States National Health Nutrition and Examination Survey 1999-2016, 24th Medical Research Conference. Hong Kong, Hong Kong Medical Journal, 2019, 25(1) suppl 1: 30.
So A.S.C., TSOI M.F., Cheung C.L., Lee S.W., Tsui S.H., Tam C.C. and Cheung B.M.Y., Serum beta-2 microglobulin predicts mortality after acute coronary syndrome, 24th Medical Research Confernece. Hong Kong, Hong Kong Medical Journal, 2019, 25 (1), supp 1: 38.
TSOI M.F., Cheung B.M.Y., Lau W.C.S. and Cheung T.T., Association between blood lead level and gout: the United States National Health Nutrition and Examination Survey 2007-2014, 24th Medical Research Conference. Hong Kong, Hong Kong Medical Journal, 2019, 25 (1), supp 1: 39.
TSOI M.F., LUI K.K.W., Cheung T.T. and Cheung B.M.Y., Association between blood lead level and hypertension: the United States National Health Nutrition and Examination Survey 1999-2006, 24th Medical Research Conference. Hong Kong, Hong Kong Medical Journal, 2019, 25 (1), supp 1: 40.
TSOI M.F., Cheung T.T. and Cheung B.M.Y., Hyperlipidaemic effect of Janus kinase inhibitors: a meta-analysis, 24th Medical Research Conference. Hong Kong, Hong Kong Medical Journal, 2019, 25 (1), supp 1: 40.
TSOI M.F., Cheung B.M.Y., Lau W.C.S. and Cheung T.T., Incidence, prevalence, and utilisation of urate-lowering therapy in Hong Kong: a population-based study, 24th Medical Research Conference. Hong Kong, Hong Kong Medical Journal, 2019, 25 (1), supp 1: 41.


Researcher : Tai CP

List of Research Outputs

Chan D.T.M., Ho S., Tai C.P., Chan C.Y.C., Chau K.M. and Yung S.S.Y., Anti-dsDNA antibodies bind to Ku70 in proximal renal tubular epithelial cells and increase matrix protein synthesis and MCP-1 secretion, ISN World Congress of Nephrology 2019.
Chan D.T.M., Ho S.S.K., Tai C.P., Chan C.Y.C., Cheng W.M., Chau K.M. and Yung S.S.Y., Anti-dsDNA antibodies bind to Ku70 in proximal renal tubular epithelial cells and increased matrix protein and cytokine secretion, American Society of Nephrology Kidney Week 2018.


Researcher : Tam CC

List of Research Outputs

Huang D., Cheng Y., Wong Y.T.A., Yung S.A., Tam C.C., Chan K.W.K., Lam C.C.S., Yiu K.H., Hai S.H.J.J., Lau C.P., Chan E.W.Y., Chiang C.E., Wong K.L., Cheung T.T., Cheung B.M.Y., Feng Y.Q., Tam N., Chen J.Y., Yue W.S., Hu H.X., Chen L., Tse H.F., Chan P.H.M. and Siu D.C.W., Thrombolysis in myocardial infarction risk score for secondary prevention of recurrent cardiovascular events in a real-world cohort of post-acute myocardial infarction patients, Circulation. 2019, 83(4): 809-817.
So A.S.C., TSOI M.F., Cheung C.L., Lee S.W., Tsui S.H., Tam C.C. and Cheung B.M.Y., Serum beta-2 microglobulin predicts mortality after acute coronary syndrome, 24th Medical Research Confernece. Hong Kong, Hong Kong Medical Journal, 2019, 25 (1), supp 1: 38.


Researcher : Tam CCT

List of Research Outputs

Kwok W.C., Ho J.C.M., Lam C.L.D., Lui M.S.M., Ip M.S.M. and Tam C.C.T., Efficacy of gefitinib at reduced dose in EGFR mutant non-small-cell lung carcinoma., 24th Medical Research Conference, Department of Medicine, HKU. Hong Kong Medical Journal. 2019, 25 (Suppl 1): 24.
Kwok W.C., Ho J.C.M., Lam C.L.D., Lui M.S.M., Ip M.S.M. and Tam C.C.T., Progression-free survival among progressed non-small-cell lung cancer with T790M mutation as guided by liquid versus tissue re-biopsy, 24th Medical Research Conference, Department of Medicine, HKU. Hong Kong Medical Journal. 2019, 25 (Suppl 1): 25.
Kwok W.C., Tam C.C.T., Lam C.L.D., Ip M.S.M. and Lui M.S.M., Pulmonary embolism developing after therapeutic drainage of malignant pleural effusions, Respiratory Medicine Case Reports. 2018, 25: 122-123.
Kwok W.C., Liang B.M., Lui M.S.M., Tam C.C.T., Sim P.Y.J., Tse E.W.C., Leung A.Y.H., Kwong Y.L., Lie A.K.W., Ip M.S.M. and Lam C.L.D., Rapid versus gradual lung function decline in bronchiolitis obliterans syndrome after haematopoietic stem cell transplantation is associated with survival outcome, Respirology. 2019, 24: 459-466.


Researcher : Tan KCB

Project Title:Role of the inducible degrader of low-density lipoprotein receptor (IDOL) in lipoprotein metabolism
Investigator(s):Tan KCB, Leung AYH
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2018


List of Research Outputs

CHENG K.F., Li H.Y., Tan K.C.B., Lu W.W. and Cheung C.L., AKAP11 is a positive regulator of osteoblast extracellular matrix formation and mineralization, 46th ECTS Congress, Budapest Hungary, May 11-14, 2019.
Chan K.W., Kwong A.S.K., Chan G.C.W., Leung C.P.S., Yiu W.H., Lui S.L., Ip T.P., Cowling B.J., Wong W.L.D., LI B., LI Y., Feng Y., Chan L.Y.Y., Leung J.C.K., Tan K.C.B., Wong C.W.V., Lai K.N. and Tang S.C.W., Best Poster Award, Good Practice In Traditional Chinese Medicine Research Association. 2018.
Chan K.W., Kwong A.S.K., Chan G.C.W., Leung C.P.S., Yiu W.H., Lui S.L., Ip T.P., Cowling B.J., Wong W.L.D., LI B., LI Y., Feng Y., Chan Y.Y., Leung J.C.K., Tan K.C.B., Wong C.W.V., Lai K.N. and Tang S.C.W., Semi-individualised Chinese Medicine Treatment for Diabetic Kidney Disease – From users’ perspectives to SCHEMATIC trial interim result and potential mechanisms, Advances in Integrative Medicine (International Congress on Complementary Medicine Research). 2019, 6: S12.
Chan M.L., Cheung C.L., Lee C.H.A., Yeung C.Y., Siu D.C.W., Leung J.Y., Pang H.K. and Tan K.C.B., Genetic variations in familial hypercholesterolemia and cascade screening in East Asians, Mol Genet Genomic Med. 2019, 7(2): e00520.
Cheng V.K., Au C.M., Tan K.C.B. and Cheung C.L., MicroRNA and Human Bone Health, JBMR Plus. 2019, 3(1): 2-13.
Cheung C.L., Tan K.C.B., Au C.M., Li H.Y. and Cheung B.M.Y., Evaluation of GDF15 as a therapeutic target of cardiometabolic diseases in human: A Mendelian randomization study, EBioMedicine. 2019, 41: 85-90.
Cheung C.L., Kung A.W.C. and Tan K.C.B., Serum follicle stimulating hormone is associated with reduced risk of diabetes in postmenopausal women. The Hong Kong osteoporosis study., Maturitas.. 2018, 114: 41-45.
Cheung Y.Y., Lee C.H.P., Tang S.M., Xu A., Au K.W., Fong H.Y., Ng K.K., KWOK H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Hai S.H.J.J., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Genetic regulation of Pigment Epithelium-Derived Factor (PEDF): an exome-chip association analysis in Chinese subjects with type 2 diabetes, Diabetes. 2019, 68: 198-206.
Ho K.Y., Li W.H.C., Lam K.W.K., Wang M.P., XIA W., Ho L.Y., Tan K.C.B., Sin H.K.M., Cheung E., Mok M.P.H. and Lam T.H., Smoking behaviours of Hong Kong Chinese hospitalised patients and predictors of smoking abstinence after discharge: a cross-sectional study, BMJ Open. 2018, 8(12): e023965.
Lee C.H.P., Woo Y.C., Lam K.S.L. and Tan K.C.B., Case series of Chinese patients with dysthyroid optic neuropathy: a single centre audit, 5th International Thyroid Eye Disease Symposium, Singapore, Feb 2019.
Lee C.H.P., Woo Y.C., Lam K.Y.J., Lee C.H.A., Lam K.S.L. and Tan K.C.B., The effects of insulin treatment on circulating ketone levels in patients with type 2 diabetes on sodium-glucose co-transporter 2 inhibitors, American Diabetes Association 79th Scientific Sessions, San Francisco, June 2019.
Leung R.Y.H., Cheung B.M.Y., Tan K.C.B., Kung A.W.C. and Cheung C.L., 25-Hydroxyvitamin D and the risk of incident diabetes in Hong Kong Chinese, Public Health Nutrition. 2019, 1-7.
Leung R.Y.H., Li H.Y., Cheung B.M.Y., Tan K.C.B., Kung A.W.C. and Cheung C.L., Serum metabolomic profiling and its association with 25-hydroxyvitamin D, Clinical Nutrition. 2019.
Lui D.T.W., Lee A.C.H., Yap Y.H.D., Chan G.S.W. and Tan K.C.B., A young Chinese man with nephrotic syndrome due to lipoprotein glomerulopathy, Journal of Clinical Lipidology. 2018, 13: 251-253.
Lui D.T.W., Woo Y.C., Chow W.S., Lee C.H.P., Lee C.H.A., Leung E.K.H., Tan K.C.B., Lam K.S.L. and Lam K.Y.J., Glycogenic hepatopathy as an unusual etiology of deranged liver function in a patient with type 1 diabetes, Medicine. 2019, 98: e15296.
Tan K.C.B., AKAP11 is a positive regulator of osteoblast extracellular matrix formation and mineralization, 46th Annual Meeting of the European Calcified Tissue Society, Budapest, May 2019.
Tan K.C.B., Carbamylated HDL and all-cause mortality in type 2 diabetes., In: 1. Tan KC, Shiu SWM, Lam JKY, Lee ACH, Wong Y., 54th European Association for the Study of Diabetes Annual Meeting, Berlin, Oct 2018.
Tan K.C.B., Cheung C.L., Lee C.H.A., Lam J.K.Y., Wong Y. and Shiu S.W.M., Galectin-3 and risk of cardiovascular events and all-cause mortality in type 2 diabetes, Diabetes Metab Res Rev. 2019, 35(2): e3093.
Tan K.C.B., “ Cardiovascular outcome trials with SGLT2 inhibitors”, Annual Scientific Meeting of the Macau Physician Society and Macau Diabetes Association, Oct 2018, Macau. 2018.
Tan K.C.B., “Advances in medical therapy for pituitary tumours”, Endocrinolgy, Diabetes and Metabolism Hong Kong Inauguration Conference, Nov 2018, Hong Kong. 2018.
Tan K.C.B., “Advances in the medical treatment of Cushing’s syndrome”, Guangdong Province CME Meeting for Physicians, Apr 2019, Shenzhen. 2019.
Tan K.C.B., “DECLARE: the impact to our daily practice”, 14th International Symposium on Healthy Aging, Mar 2019, Hong Kong. 2019.
Tan K.C.B., “HDL function in diabetes”, Xijing Diabetes and Endocrine Forum, June 2019, Xi’an.. 2019.
Tan K.C.B., “Place of therapy of lipid lowering agents and newer anti-diabetic agents in reducing cardiovascular outcomes”, 3rd JAPAC Medical Collegium, May 2019, Sendai. 2019.
Tan K.C.B., “Practical Approach to Lipid Disorders”, Plenary lecture, 35th Annual Scientific Meeting of Hong Kong Society of Endocrinology, Metabolism and Reproduction, Nov 2018. 2018.
Tan K.C.B., “Treating hyperlipidaemia”, Plenary lecture, Endocrinology, Diabetes and Metabolism Hong Kong Inauguration Conference, Nov 2018, Hong Kong. 2018.
Tan K.C.B., “Updates on familial hypercholesterolemia”, Hong Kong Society of Endocrinology, Metabolism and Reproduction Symposium, June 2019, Hong Kong. 2019.
Tomlinson B., Chan J.C., Chan W.B., Chen W.W., Chow F.C., Li S.K., Kong A.P., Ma R.C., Siu D.C.W., Tan K.C.B., Wong L.K., Yeung V.T., But B.W., Cheung P.T., Fu C.C., Tung J.Y., Wong W.C. and Yau H.C., Guidance on the management of familial hypercholesterolaemia in Hong Kong: an expert panel consensus viewpoint., Hong Kong Medical Journal. Hong Kong, Hong Kong Academy of Medicine, 2018, 24(4): 408–15.
Wan Y.F., Yu Y.T.E., Chin W.Y., Fung S.C.C., Kwok R.L.P., Chao D.V.K., Chan K.H., Hui E.M.T., Tsui W.W.S., Tan K.C.B., Fong D.Y.T. and Lam C.L.K., Ten-year risk prediction models of complications and mortality of Chinese patients with diabetes mellitus in primary care in Hong Kong: a study protocol, BMJ Open. 2018, 8: e023070.


Researcher : Tan V.P.Y.

Project Title:Prevalence of Fermentable Oligo-, Di- and Mono- saccharides and Polyols (FODMAPS) malabsorption in Chinese Control, Functional Dyspepsia, Irritable Bowel and Inflammatory Bowel Disease Patients
Investigator(s):Tan VPY
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:06/2011


Project Title:Influence of phytochemicals present in plant based supplementation on stool microbiota of control versus colon cancer subjects: A feasibility study
Investigator(s):Tan VPY, Panagiotou I, Dufay S, Poon TCJ
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:06/2014


Project Title:Factors driving a response in functional dyspepsia subjects treated with Rifaximin: Effect on upper gastrointestinal gas production, pH, transit time, mucosal histopathology.
Investigator(s):Tan VPY
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:05/2018




Researcher : Tan VPY

Project Title:Prevalence of Fermentable Oligo-, Di- and Mono- saccharides and Polyols (FODMAPS) malabsorption in Chinese Control, Functional Dyspepsia, Irritable Bowel and Inflammatory Bowel Disease Patients
Investigator(s):Tan VPY
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:06/2011


Project Title:Influence of phytochemicals present in plant based supplementation on stool microbiota of control versus colon cancer subjects: A feasibility study
Investigator(s):Tan VPY, Panagiotou I, Dufay S, Poon TCJ
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:06/2014


Project Title:Factors driving a response in functional dyspepsia subjects treated with Rifaximin: Effect on upper gastrointestinal gas production, pH, transit time, mucosal histopathology.
Investigator(s):Tan VPY
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:05/2018




Researcher : Tang CW

Project Title:Aliskiren combined with losartan in immunoglobulin A nephropathy: an open-label pilot study
Investigator(s):Tang SCW, Lai KN
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:10/2010


Project Title:King's/HKU Fellowship Awards 2012-13
Investigator(s):Tang SCW
Department:Medicine
Source(s) of Funding:King's/HKU Fellowship Awards
Start Date:07/2012


Project Title:Semi-structured Chinese Medicine Treatment as an Adjuvant Therapy to the Management of Diabetic Nephropathy – A pilot comparative clinical trial
Investigator(s):Tang SCW, Feng Y
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:07/2015


Project Title:Exploring the Role of Reprogrammed Mesenchymal Stem Cells in Diabetic Nephropathy
Investigator(s):Tang SCW
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:07/2015
Completion Date:01/2019


Project Title:Exploring the biphasic and dual roles of Wnt/beta-catenin signaling in proteinuric nephropathy
Investigator(s):Tang SCW, Liu Y, Yiu WH
Department:Medicine
Source(s) of Funding:National Natural Science Foundation of China (NSFC) - General Program
Start Date:01/2016


Project Title:Exploring the Role of Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells in Nephropathies
Investigator(s):Tang SCW, Liu Y, Tse HF
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:07/2016
Completion Date:08/2019


Project Title:Outstanding Researcher Award 2015-16
Investigator(s):Tang SCW
Department:Medicine
Source(s) of Funding:Outstanding Researcher Award
Start Date:11/2016


Project Title:Cost-Effectiveness analysis of staged screening of BK virus-associated nephropathy using cytology and serum quantitative polymerase chain reaction
Investigator(s):Tang SCW, Ma KMM, Chan JFW
Department:Medicine
Source(s) of Funding:Hong Kong Society of Nephrology Ltd.
Start Date:12/2016


Project Title:Role of kallistatin in Wnt/β-catenin signaling during renal fibrosis
Investigator(s):Tang SCW, Yiu WH
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2017


Project Title:Mechanisms of Renal Inflammation: Role of Toll-like Receptor 4
Investigator(s):Tang SCW
Department:Medicine
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:06/2017


Project Title:Efficacy, safety and response predictors of adjuvant Astragalus therapy for diabetic kidney disease – an open-label randomised controlled trial with responder regression analysis
Investigator(s):Tang SCW, Chan KW, Zhang Y
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:07/2017


Project Title:Dissecting the anti-inflammatory properties of kallistatin in diabetic nephropathy
Investigator(s):Tang SCW
Department:Medicine
Source(s) of Funding:Hong Kong Society of Nephrology Ltd.
Start Date:11/2017


Project Title:Protease-activated receptor-1 (PAR-1)–targeted therapy: potential for preventing renal fibrosis
Investigator(s):Tang SCW, Yiu WH
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:07/2018


Project Title:Role of renal tubular Wnt/β-catenin in modulating renal inflammation
Investigator(s):Tang SCW, Yiu WH
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2019


Project Title:Role and mechanism of C5a/C5aR signaling on the development of inflammation and fibrosis in diabetic nephropathy
Investigator(s):Tang SCW
Department:Medicine
Source(s) of Funding:National Natural Science Foundation of China (NSFC) - General Program
Start Date:01/2019


Project Title:Low-Cost Highly Sensitive Glucose Sensors for Noninvasive Glucose Detection
Investigator(s):Tang SCW
Department:Medicine
Source(s) of Funding:Midstream Research Programme for Universities (MRP)
Start Date:03/2019


List of Research Outputs



Researcher : Tang SCW

Project Title:Aliskiren combined with losartan in immunoglobulin A nephropathy: an open-label pilot study
Investigator(s):Tang SCW, Lai KN
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:10/2010


Project Title:King's/HKU Fellowship Awards 2012-13
Investigator(s):Tang SCW
Department:Medicine
Source(s) of Funding:King's/HKU Fellowship Awards
Start Date:07/2012


Project Title:Semi-structured Chinese Medicine Treatment as an Adjuvant Therapy to the Management of Diabetic Nephropathy – A pilot comparative clinical trial
Investigator(s):Tang SCW, Feng Y
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:07/2015


Project Title:Exploring the Role of Reprogrammed Mesenchymal Stem Cells in Diabetic Nephropathy
Investigator(s):Tang SCW
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:07/2015
Completion Date:01/2019


Project Title:Exploring the biphasic and dual roles of Wnt/beta-catenin signaling in proteinuric nephropathy
Investigator(s):Tang SCW, Liu Y, Yiu WH
Department:Medicine
Source(s) of Funding:National Natural Science Foundation of China (NSFC) - General Program
Start Date:01/2016


Project Title:Exploring the Role of Induced Pluripotent Stem Cell-Derived Mesenchymal Stem Cells in Nephropathies
Investigator(s):Tang SCW, Liu Y, Tse HF
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:07/2016
Completion Date:08/2019


Project Title:Outstanding Researcher Award 2015-16
Investigator(s):Tang SCW
Department:Medicine
Source(s) of Funding:Outstanding Researcher Award
Start Date:11/2016


Project Title:Cost-Effectiveness analysis of staged screening of BK virus-associated nephropathy using cytology and serum quantitative polymerase chain reaction
Investigator(s):Tang SCW, Ma KMM, Chan JFW
Department:Medicine
Source(s) of Funding:Hong Kong Society of Nephrology Ltd.
Start Date:12/2016


Project Title:Role of kallistatin in Wnt/β-catenin signaling during renal fibrosis
Investigator(s):Tang SCW, Yiu WH
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2017


Project Title:Mechanisms of Renal Inflammation: Role of Toll-like Receptor 4
Investigator(s):Tang SCW
Department:Medicine
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:06/2017


Project Title:Efficacy, safety and response predictors of adjuvant Astragalus therapy for diabetic kidney disease – an open-label randomised controlled trial with responder regression analysis
Investigator(s):Tang SCW, Chan KW, Zhang Y
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:07/2017


Project Title:Dissecting the anti-inflammatory properties of kallistatin in diabetic nephropathy
Investigator(s):Tang SCW
Department:Medicine
Source(s) of Funding:Hong Kong Society of Nephrology Ltd.
Start Date:11/2017


Project Title:Protease-activated receptor-1 (PAR-1)–targeted therapy: potential for preventing renal fibrosis
Investigator(s):Tang SCW, Yiu WH
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:07/2018


Project Title:Role of renal tubular Wnt/β-catenin in modulating renal inflammation
Investigator(s):Tang SCW, Yiu WH
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2019


Project Title:Role and mechanism of C5a/C5aR signaling on the development of inflammation and fibrosis in diabetic nephropathy
Investigator(s):Tang SCW
Department:Medicine
Source(s) of Funding:National Natural Science Foundation of China (NSFC) - General Program
Start Date:01/2019


Project Title:Low-Cost Highly Sensitive Glucose Sensors for Noninvasive Glucose Detection
Investigator(s):Tang SCW
Department:Medicine
Source(s) of Funding:Midstream Research Programme for Universities (MRP)
Start Date:03/2019


List of Research Outputs

Barratt J. and Tang S.C.W., Treatment of IgA Nephropathy: Evolution Over Half a Century, Seminars in Nephrology. 2018, 38: 531-540.
CHEN X., LAM K.H., Feng Y., Xu K., Sze S.C.W., Tang S.C.W., Leung G.P.H., Lee C.K.F., Shi J., Yang Z., Li S., Zhang Z. and Zhang Y., Ellagitannins from Pomegranate Ameliorates 5-Fluorouracil-Induced Intestinal Mucositis in Rats while Enhancing Its Chemotoxicity against HT-29 Colorectal Cancer Cells through Intrinsic Apoptosis Induction, Journal of Agricultural and Food Chemistry. 2018, 66: 7054-7064.
Chan G.C.W. and Tang S.C.W., Proteinuria reaffirmed as a risk modifier in diabetic chronic kidney disease, Nephrol Dial Transplant. 2018, 2018.
Chan K.W., Kwong A.S.K., Chan G.C.W., Leung C.P.S., Yiu W.H., Lui S.L., Ip T.P., Cowling B.J., Wong W.L.D., LI B., LI Y., Feng Y., Chan L.Y.Y., Leung J.C.K., Tan K.C.B., Wong C.W.V., Lai K.N. and Tang S.C.W., Best Poster Award, Good Practice In Traditional Chinese Medicine Research Association. 2018.
Chan K.W., Kwong A.S.K., Chan G.C.W., Leung C.P.S., Yiu W.H., Lui S.L., Ip T.P., Cowling B.J., Wong W.L.D., LI B., LI Y., Feng Y., Chan Y.Y., Leung J.C.K., Tan K.C.B., Wong C.W.V., Lai K.N. and Tang S.C.W., Semi-individualised Chinese Medicine Treatment for Diabetic Kidney Disease – From users’ perspectives to SCHEMATIC trial interim result and potential mechanisms, Advances in Integrative Medicine (International Congress on Complementary Medicine Research). 2019, 6: S12.
Cheung C.Y. and Tang S.C.W., An update on cancer after kidney transplantation, Nephrology Dialysis Transplantation. 2019, 34: 914-920.
Cheung C.Y. and Tang S.C.W., Oncology in nephrology comes of age: A focus on chronic dialysis patients, Nephrology. 2019, 24: 380-386.
Floege J., Barbour S.J., Cattran D.C., Hogan J.J., Nachman P.H., Tang S.C.W., Wetzels J.F.M., Cheung M., Wheeler D.C., Winkelmayer W.C., Rovin B.H., Adler S.G., Alpers C.E., Ayoub I., Bagga A., Barratt J., Caster D.J., Chan D.T.M., Chang A., Choo J.C.J., Cook H.T., Coppo R., Fervenza F.C., Fogo A.B., Fox J.G., Gibson K.L., Glassock R.J., Harris D., Hodson E.M., Hoxha E., Iseki K., Jennette J.C., Jha V., Johnson D.W., Kaname S., Katafuchi R., Kitching A.R., Lafayette R.A., Li P.K.T., Liew A., Lv J., Malvar A., Maruyama S., Mejía-Vilet J.M., Moeller M.J., Mok C.C., Nester C.M., Noiri E., O'Shaughnessy M.M., Özen S., Parikh S.M., Park H.C., Peh C.A., Pendergraft W.F., Pickering M.C., Pillebout E., Radhakrishnan J., Rathi M., Roccatello D., Ronco P., Smoyer W.E., Tesař V., Thurman J.M., Trimarchi H., Vivarelli M., Walters G.D., Wang A.Y.M. and Wenderfer S.E., Management and treatment of glomerular diseases (part 1): conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference, Kidney International. 2019, 95: 268-280.
LI B., Leung J.C.K., Chan L.Y., Yiu W.H., Lai K.N. and Tang S.C.W., Mesenchymal Stem Cells Derived from Induced Pluripotent Stem Cells and Bone Marrow Are Equally Effective in Ameliorating Lipotoxicity-Induced Kidney Injury (Conference Abstract)., J Am Soc Nephrol. 2018, 29: 284.
LIU J., CHEN X., Chen H., Shi J., Leung G.P.H., Tang S.C.W., Lao L., Yip H.K.F., Lee C.K.F., Sze S.C.W., Zhang Z. and Zhang Y., Downregulation of Aquaporin 9 Exacerbates Beta-amyloid-induced Neurotoxicity in Alzheimer’s Disease Models In vitro and In vivo, Neuroscience. 2018, 394: 72-82.
Lau G.K.K., Lau C.D., Chan D.T.M. and Tang S.C.W., 1962 Albert Lasker Basic Medical Resaerch Award – Choh Hao Li (Ch. 12)., Nobel and Lasker Laureates of Chinese Descent in Literature and Science, Edited by Todd S. Ing, Keith K. Lau, Joseph M. Chan, Hon-lok Tang and Angela T. Hadsell and Laurence K. Chan,. World Scientific, Singapore, 2019, 183-199.
Leung J.C.K., Lai K.N. and Tang S.C.W., Role of Mesangial-Podocytic-Tubular Cross-Talk in IgA Nephropathy, Seminars in Nephrology. 2018, 38: 485-495.
Sadat‐Ebrahimi S.R., Parnianfard N., Vahed N., Babaei H., Ghojazadeh M., Tang S.C.W. and Azarpazhooh A., An evidence‐based systematic review of the off‐label uses of lisinopril, British Journal of Clinical Pharmacology. 2018, 84: 2502-2521.
Tang S.C.W., An Overview of IgA Nephropathy: 50 Years On, Seminars in Nephrology. 2018, 38: 433-434.
Tang S.C.W., CKD prevention: Perspectives in Hong Kong, Nephrology. 2018, 23: 72-75.
Tang S.C.W., CKDu in S.E. Asia, World Congress of Nephrology, Apr 13, 2019, Melbourne, Australia. 2019.
Tang S.C.W., Wong A.K. and Mak S.K., Clinical practice guidelines for the provision of renal service in Hong Kong: General Nephrology, Nephrology. 2019, 24: 9-26.
Tang S.C.W., Croucher Senior Medical Research Fellowship 2019 – 2020,, 2018.
Tang S.C.W., Diabetic Kidney Disease: Of Mice and Men, Kolling Institute Seminar Series, University of Sydney, Royal North Shore Hospital, Sep 12, 2018, Sydney, Australia. 2018.
Tang S.C.W., Editorial Advisory Board (one of 7 international faculties in the same role), appointed in Sep 2018, Seminars in Nephrology. 2018.
Tang S.C.W., Guest Editor, Seminars in Nephrology, 2018, Vol.38, no.5 for September 2018.
Tang S.C.W., IgA Nephropathy – 50 Years and What Have We Learned?, Australia and New Zealand Society of Nephrology (ANZSN) Annual Scientific Meeting, Sep 11, 2018, Sydney, Australia.. 2018.
Tang S.C.W., IgA Nephropathy: 50 Years On, Fifth Xiangya International Forum of Kidney Disease and Congress on Kidney Diseases in 6 Provinces of Central and South China, Nov 17, 2018, Changsha, China. 2018.
Tang S.C.W., IgA Nephropathy: 50 Years On, Keynote lecture, Hong Kong Society of Nephrology Annual Scientific Meeting, 30 Sep 2018, Hong Kong. 2019.
Tang S.C.W., IgA nephropathy: What next after 50 years?, Mainland-Hong Kong Frontier Discipline Forum. Nephrology: from Bench to Bedside, May 7, 2019, Hangzhou. 2019.
Tang S.C.W., International Honorary Member of the Japanese Society of Nephrology (awarded to one Asian and one European), 2019.
Tang S.C.W., Nutritional strategies to halt vascular calcification in CKD, KDIGO Clinical Practice Conference, Sep 14, 2018, Xi’An, China. 2018.
Tang S.C.W. and Sharma K., Pathogenesis, Clinical Manifestations, and Natural History of Diabetic Kidney Disease (Ch. 30, Section V), In: John Feehally, Jurgen Floege, Richard Johnson and Marcello Tonelli , Comprehensive Clinical Nephrology (6th Ed). Elsevier, Philadelphia, USA, 2018, pp 357-375.
Tang S.C.W., Renal inflammation: its pathogenetic role in diabetic kidney disease, European Renal Association and European Dialysis and Transplant Association (ERA-EDTA) Congress, Jun 14, 2019, Budapest, Hungary. 2019.
Tang S.C.W., The landscape of IgA nephropathy in 2019, Asian Pacific Society of Nephrology-Japanese Society of Nephrology CME course, Jun 20, 2019, Nagoya, Japan. 2019.
Tang S.C.W., Treatment of DKD: The position of SGLT2 inhibitors, Nanjing International Nephrology Forum & National CME Course, Jun 29, 2019, Nanjing, China. 2019.
Tang S.C.W., Update in Management of Diabetic Nephropathy, Asian Pacific Society of Nephrology-ANZSN CME course, Sep 8, 2018, Sydney, Australia. 2018.
Tang S.C.W., Why is the risk of stroke so high in CKD and in dialysis patients?, European Renal Association and European Dialysis and Transplant Association (ERA-EDTA) Congress, Jun 15, 2019, Budapest, Hungary. 2019.
Tang S.C.W., as one of four co-editors – an entire issue on Clinical Practice Guideline for Renal Services in Hong Kong (Published in April 2019), Nephrology. 2019.
Tang S.C.W., as the sole Editor (Vol. 38, no. 5) – an entire issue on IgA Nephropathy: 50 Years On (Published in September, 2018), Seminar in Nephrology. 2018.
Tang S.C.W., “Current Status & Future of Hemodialysis and Vascular Access in Hong Kong”, Association of Vascular Access and Interventional Renal Physicians (AVATAR), Jul 20, 2018, New Delhi, India. 2018.
Tang S.C.W., “Nutritional strategies to halt vascular calcification in ESRD patients” and “Unmet Needs in Clinical Trials of Diabetic Kidney Disease (web symposium to be broadcast to Korean doctors in September 2018)” (Aug 11, 2018) and “Low turnover disease in CKD” (Aug 12, 2018), 2018 , 2018 Sanofi CKD-MBD Masterclass, Seoul, Korea. 2018.
Wang J., Zhang L., Tang S.C.W., Kashihara N., Kim Y.S., Togtokh A., Yang C.W. and Zhao M.H., ISN North and East Asia Regional Board. Disease burden and challenges of chronic kidney disease in North and East Asia., Kidney Int. 2018, 2018: 94(1):22-25.
Yiu W.H., Wong D.W., LOK W.Y., Liu W.H., LI Y., CHAN L.Y., Leung J.C.K., Lan H.Y. and Tang S.C.W., The Long Noncoding RNA Meg3 Mediates TLR4–Induced Renal Inflammation in Experimental Obstructive Nephropathy (Conference Abstracts) , J Am Soc Nephrol . 2018, 29: 953.


Researcher : Tang SOC

List of Research Outputs

Li C., Yap Y.H.D., Chan S.W.G., Wen Y., Li H., Tang S.O.C., Li X., Li X. and Chan D.T.M., Clinical Outcomes and Clinico-pathological Correlations in Lupus Nephritis with Kidney Biopsy Showing Thrombotic Microangiopathy, The Journal of Rheumatology. 2019, jrheum.180773.
Yap Y.H.D., Tang S.O.C., Chan G.C.W., Kwan P.Y.L., Ma K.M.M., Mok M.Y. and Chan D.T.M., Longterm Data on Sirolimus Treatment in Patients with Lupus Nephritis, The Journal of Rheumatology. 2018, 45(12): 1663-1670.
Yap Y.H.D., Tam C.H., Yung S.S.Y., Wong S., Tang S.O.C., Mok M.Y.T., Yuen C.K.Y., Ma M.K.M., Lau W.C.S. and Chan D.T.M., Pharmacokinetics and pharmacogenomics of mycophenolic acid and its clinical correlations in maintenance immunosuppression for lupus nephritis, Nephrol Dial Transplant. 2018.
Yap Y.H.D., Tam C.H., Yung S.S.Y., Wong S., Tang S.O.C., Mok M.Y.T., Yuen K.Y.C., Ma K.M.M., Lau W.C.S. and Chan D.T.M., Pharmacokinetics and pharmacogenomics of mycophenolic acid and its clinical correlations in maintenance immunosuppression for lupus nephritis, Nephrology Dialysis Transplantation. 2018.


Researcher : Tang YFV

List of Research Outputs

Chiu W.Y.J., Leung R.C.Y., Tang Y.F.V., Cheuk W.Y.I., Lo L.F., Kwok G.W., Wong H.Y.H., Suen T.K.D., Cheung P., Wong T.T., Yau T.C.C. and Kwong A., Changing pattern of recurrences in patients with early HER2-positive breast cancer receiving neoadjuvant chemotherapy in the era of dual anti-HER2 therapy, Postgraduate Medical Journal. 2019, 95: 155-161.


Researcher : Teo KC

List of Research Outputs

Lau G.K.K., Tsang C.O.A., Teo K.C., Li H.L., Chu L.K.W., Li J.C.H., Chan M.K.C., Wan V.H.L., Hui S.K. and Mak H.K.F., Age-Specific Associations of Renal Impairment and Cerebral Small Vessel Disease Burden in Chinese with Ischaemic Stroke, Journal of Stroke and Cerebrovascular Diseases. 2019, 28: 1274-1280.


Researcher : Tong SM

List of Research Outputs

Lam Y.F., Seto W.K.W., Tong S.M., Cheung K.S.M., Lo O.S.H., Hung F.N.I., Law W.L. and Leung W.K., Rates of metachronous adenoma after curative resection for left-sided or right-sided colon cancer, Intestinal Research. 2018, 16: 619-627.


Researcher : Tsang HLH

List of Research Outputs

Chung H.Y., Lau W.C.S., Tsang H.L.H., Wong O.M., Chan S.C.W., Li P.H. and Lee K.H., Clinical Associations of Uveitis in Axial Spondyloarthritis Group and Ankylosing Spondylitis Group: Do They Represent the Same Disease?, Journal of Clinical Rheumatology. 2018.
Chung H.Y., Lau W.C.S., Tsang H.L.H., Chan C.W.S., Li P.H., Lee K.H. and Wong P.Y.S., Diffusion-weighted imaging versus short tau inversion recovery sequence: Usefulness in detection of active sacroiliitis and early diagnosis of axial spondyloarthritis, PLoS one. 2018.
Tsang H.L.H., Cheung J.P.Y., Wong C.K.H., Cheung W.H.P., Lau W.C.S. and Chung H.Y., Psychometric validation of the EuroQoL 5-dimension (EQ-5D) questionnaire in patients with spondyloarthritis, Arthritis Research & Therapy. 2019, 21: 41.


Researcher : Tse EWC

Project Title:Outstanding Young Researcher Award 2009-10
Investigator(s):Tse EWC
Department:Medicine
Source(s) of Funding:Outstanding Young Researcher Award
Start Date:12/2010


Project Title:PTCL Study - PD-1 blockade with pembrolizumab in relapsed/refractory mature T-cell and NK-cell lymphomas
Investigator(s):Tse EWC, Kwong YL, Singh GHH
Department:Medicine
Source(s) of Funding:Merck, Sharp and Dohme (Asia) Ltd. - General Award
Start Date:06/2017


Project Title:Targeting BCL6 in diffuse large B-cell lymphoma with arsenic trioxide
Investigator(s):Tse EWC, Kwong YL
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:08/2018


List of Research Outputs

Cheng C.W. and Tse E.W.C., PIN1 in Cell Cycle Control and Cancer, Frontiers in Pharmacology. 2018, 9.
Kwok W.C., Liang B.M., Lui M.S.M., Tam C.C.T., Sim P.Y.J., Tse E.W.C., Leung A.Y.H., Kwong Y.L., Lie A.K.W., Ip M.S.M. and Lam C.L.D., Rapid versus gradual lung function decline in bronchiolitis obliterans syndrome after haematopoietic stem cell transplantation is associated with survival outcome, Respirology. 2019, 24: 459-466.
ZHOU Y., WANG H., Tse E.W.C., Li H. and Sun H., Cell cycle-dependent uptake and cytotoxicity of arsenic-based drugs in single Leukemia cells, Analytical Chemistry. USA, ACS, 2018, 90: 10465-10471.


Researcher : Tse HF

Project Title:Outstanding Researcher Award 2007-2008
Investigator(s):Tse HF
Department:Medicine
Source(s) of Funding:Outstanding Researcher Award
Start Date:10/2008


Project Title:Direct endomyocardial injection of autologous bone marrow cells for treatment of patients with "end-stage" ischaemic heart failure
Investigator(s):Tse HF, Lau CP, Kwong YL, Siu DCW, Lee SWL, Chan HWF, Lam L, Lee KLF, Chan WS, Lam YM
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:01/2009


Project Title:Personalized Medicine for Cardiovascular Diseases: From Genomic Testing and Biomarkers to Human Pluripotent Stem Cell Platform
Investigator(s):Tse HF, Xu A, Sham PC, Lam KSL, Lam TH, Cheung BMY, Tan KCB, Siu DCW, Lian Q, Cherny SS, Lam CW
Department:Medicine
Source(s) of Funding:Theme-based Research Scheme
Start Date:01/2012
Completion Date:12/2018


Project Title:Development of Wireless Powered Miniature Pacing Devices for Cardiac Rhythm Management
Investigator(s):Tse HF, Siu DCW, Lai KWH
Department:Medicine
Source(s) of Funding:Innovation and Technology Support Programme (Tier 3)
Start Date:12/2014


Project Title:Discovery of New Approaches for Treating Hyperlipidemia Using an Induced Pluripotent Stem Cell (iPSC)-Based Platform
Investigator(s):Tse HF, Esteban MA, Siu DCW, Lian Q
Department:Medicine
Source(s) of Funding:CAS - Croucher Funding Scheme for Joint Laboratories
Start Date:10/2016


Project Title:Sudden Unexpected Death (SUD) in Hong Kong
Investigator(s):Tse HF
Department:Medicine
Source(s) of Funding:Sun Chieh Yeh Heart Foundation - General Award
Start Date:06/2017


Project Title:Klf4 interacts with PCG-1/ERR to regulate mitochondrial biogenesis and dynamics in rescuing complex I dysfunction-provoked mesenchymal stem cell ageing
Investigator(s):Tse HF, Yan B, Lian Q
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:09/2017


Project Title:Generation of a Familial Hypercholesterolemia Human Liver Chimeric Rabbit Model
Investigator(s):Tse HF, Au KW
Department:Medicine
Source(s) of Funding:Guangdong-Hong Kong Technology Cooperation Funding Scheme
Start Date:07/2018


Project Title:Generation of a Familial Hypercholesterolemia Human Liver Chimeric Rabbit Model
Investigator(s):Tse HF, Au KW
Department:Medicine
Source(s) of Funding:Postdoctoral Hub Programme for ITF projects
Start Date:11/2018


Project Title:Generation of a Familial Hypercholesterolemia Human Liver Chimeric Rabbit Model
Investigator(s):Tse HF, Au KW
Department:Medicine
Source(s) of Funding:Postdoctoral Hub Programme for ITF projects
Start Date:11/2018


List of Research Outputs

CHEN Y., Au T.W.K., Chan D., Sit K.Y., Zhen Z., Ho K.L., Wong D., Ho L.M., Yap Y.H.D., Lam Y.M., Lau C.P., Tse H.F., Chan D.T.M. and Yiu K.H., Clinical Benefit of Valvular Surgery in Patients with Chronic Kidney Disease, International Heart Journal. 2018, 59: 759-765.
CHEN Y., Liu Y., Seto W.K.W., Wu M., YU Y., Lam Y.M., Au W.K., Chan D., Sit K.Y., Ho L.M., Tse H.F. and Yiu K.H., Prognostic Value of Hepatorenal Function By Modified Model for End‐stage Liver Disease (MELD) Score in Patients Undergoing Tricuspid Annuloplasty, Journal of the American Heart Association. 2018, 7: e009020.
Chan Y.H., Ngai M.C., Chen Y., Wu M., YU Y., ZHEN Z., Lai K.W.H., Cheung T.T., Ho L.M., Chung H.Y., Lau W.C.S., Tse H.F. and Yiu K.H., Cumulative Rheumatic Inflammation Modulates the Bone–Vascular Axis and Risk of Coronary Calcification, Journal of the American Heart Association. 2019, 8.
Chan Y.H., Hai S.H.J.J. and Tse H.F., Malignant Arrhythmia in a 40-Year-Old Man, JAMA Cardiology. 2018, 3: 661.
Chan Y.H., Ngai M.C., Chen Y., Wu M., YU Y., ZHEN Z., Lai K.W.H., Cheung T.T., Ho L.M., Chung H.Y., Lau W.C.S., Lau C.P., Tse H.F. and Yiu K.H., Osteogenic circulating endothelial progenitor cells are linked to electrocardiographic conduction abnormalities in rheumatic patients, Annals of Noninvasive Electrocardiology. 2019, e12651.
Chen Y., Au T.W.K., Chan D., Sit K.Y., Zhen Z., Ho K.L., Wong D., Ho L.M., Yap Y.H.D., Lam Y.M., Lau C.P., Tse H.F., Chan D.T.M. and Yiu K.H., Clinical Benefit of Valvular Surgery in Patients with Chronic Kidney Disease. , International heart journal. 2018, 59(4): 759-765.
Chen Y., Liu Y., Seto W.K.W., Wu M., YU Y., Lam Y.M., Au T.W.K., Sit K.Y., Ho L.M., Tse H.F. and Yiu K.H., Prognostic Value of Hepatorenal Function By Modified Model for End-stage Liver Disease (MELD) Score in Patients Undergoing Tricuspid Annuloplasty, Journal of the American Heart Association. 2018, 7(14): 1-11.
Chen Y., Liu Y., Wu M., Lam Y.M., Ho L.M., Lau C.P., Au T.W.K., Tse H.F. and Yiu K.H., Prognostic value of tricuspid valve geometry and leaflet coaptation status in patients undergoing tricuspid annuloplasty: a three-dimensional echocardiography study, PCR Tokyo Valves 2019.
Cheung Y.Y., Lee C.H.P., Tang S.M., Xu A., Au K.W., Fong H.Y., Ng K.K., KWOK H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Hai S.H.J.J., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Genetic regulation of Pigment Epithelium-Derived Factor (PEDF): an exome-chip association analysis in Chinese subjects with type 2 diabetes, Diabetes. 2019, 68: 198-206.
Feng X.F., Hai S.H.J.J., Ma Y., Wang Z.Q. and Tse H.F., Sudden Cardiac Death in Mainland China, Circulation: Arrhythmia and Electrophysiology. 2018, 11: e006684.
Hai S.H.J.J., Fang J., Tam C.C., Wong C.K., Un C.K., Siu D.C.W., Lau C.P. and Tse H.F., Safety and feasibility of a midseptal implantation technique of a leadless pacemaker, Heart Rhythm. 2019, 16: 896-902.
Huang D., Cheng Y., Wong Y.T.A., Yung S.A., Tam C.C., Chan K.W.K., Lam C.C.S., Yiu K.H., Hai S.H.J.J., Lau C.P., Chan E.W.Y., Chiang C.E., Wong K.L., Cheung T.T., Cheung B.M.Y., Feng Y.Q., Tam N., Chen J.Y., Yue W.S., Hu H.X., Chen L., Tse H.F., Chan P.H.M. and Siu D.C.W., Thrombolysis in myocardial infarction risk score for secondary prevention of recurrent cardiovascular events in a real-world cohort of post-acute myocardial infarction patients, Circulation. 2019, 83(4): 809-817.
JIANG D., XIONG G., FENG H., ZHANG Z., Chen P., Yan B., CHEN L., Kesavamoorthy G., MA C.Y., Li C., HAN S., Zhang Y., Liao C., Lee T.L., Tse H.F., Fu Q.L., Chiu K. and Lian Q., Donation of mitochondria by iPSC-derived mesenchymal stem cells protects retinal ganglion cells against mitochondrial complex I defect-induced degeneration, Theranostics. Australia, Ivyspring International Publisher, 2019, 2019, Vol. 9, Issue 8: 2395-2410.
Jiang D., Xiong G., Feng H., ZHANG Z., Chen P., Yan B., Chen P., Kesavamoorthy G., Ma C.Y., Li C., Han S., Zhang Y., Liao C., Lee T.L., Tse H.F., Fu Q., Chiu K. and Lian Q., Donation of mitochondria by iPSC-derived mesenchymal stem cells protects retinal ganglion cells against mitochondrial complex I defect-induced degeneration, Theranostics. 2019, 9(8): 2395-2410.
Kwok S.Y. and Tse H.F., Hybrid cardiac resynchronization with leadless pacemaker and transvenous coronary sinus lead, Europace. 2018, 20(9): 1505.
LI B., Leung J.C.K., Chan Y.Y., Yiu W.H., LI Y., LOK W.Y., Liu W.H., Chan K.W., Tse H.F., Lai K.N. and Lai K.N., Amelioration of Endoplasmic Reticulum Stress by Mesenchymal Stem Cells Via Hepatocyte Growth Factor/c‐Met Signaling in Obesity‐Associated Kidney Injury, STEM CELLS Translational Medicine. 2019.
Liao S., Zhang Y., Ting S.H.E.R.W.I.N., ZHEN Z., Luo F.A.N., Zhu Z., JIANG Y., SUN S., Lai K.W.H., Lian Q. and Tse H.F., Potent immunomodulation and angiogenic effects of mesenchymal stem cells versus cardiomyocytes derived from pluripotent stem cells for treatment of heart failure, Stem Cell Research & Therapy. 2019, 10.
Liu F.Z., Lin W.D., Liao H.T., Peng J., Xue Y.M., Zhan X.Z., Zhu J.M., Yiu K.H., Li Y.F., Tse H.F., Shi L., Fang X.H. and Wu S.L., Mid-term outcomes of concomitant left atrial appendage closure and catheter ablation for non-valvular atrial fibrillation: a multicenter registry., Heart Vessels. 2019, 34(5): 860-867.
Lui M.S.M., Tse H.F., Mak J.C.W., Lam C.L.D., Chan W.S., Chong W.C. and Ip M.S.M., Untreated Obstructive Sleep Apnea Is Associated With Myocardial Injury Independent of Blood Pressure Control in Hypertension, Journal of Clinical Sleep Medicine. 2018, 14: 1841-1847.
Mura M., Lee Y.K., Pisano F., Ginevrino M., Boni M., Calabrò F., Crotti L., Schwartz P.J., Tse H.F. and Gnecchi M., Generation of the human induced pluripotent stem cell (hiPSC) line PSMi004-A from a carrier of the KCNQ1-R594Q mutation. , Stem Cell Res. 2019.
Mura M., Lee Y.K., Pisano F., Ginevrino M., Boni M., Calabrò F., Crotti L., Schwartz P.J., Tse H.F. and Gnecchi M., Generation of the human induced pluripotent stem cell (hiPSC) line PSMi005-A from a patient carrying the KCNQ1-R190W mutation., Stem Cell Res. 2019, 37.
Ng K.M., Lau V.Y.M., Vidhu D., Cai Z., Lee Y.K., Lai K.W.H., Tse H.F. and Siu D.C.W., Empagliflozin Ammeliorates High Glucose Induced-Cardiac Dysfuntion in Human iPSC-Derived Cardiomyocytes, Scientific Reports. 2018, 8.
Tse H.F., Chair, European Society of Cardiology (ESC Congress, 2018, Aug 26-29 (Munich, Germany) Basic Science, Cardiac Diseases, 2018.
Tse H.F., Chair, 11th Korean Heart Rhythm Society Symposium 2019, Grand Walkerhill, Seoul, Korea.” Atrial Fibrillation”& “YIA”, 2019.
Tse H.F., Invited Speaker, CASNA Annual Australia 2018 Device detected atrial high rate episdoes: Significance and management, High-resolution mapping of atrial arrhythmias in repaired congenital heart disease, 2018.
Tse H.F., Invited Speaker, 7th Annual International Symposium on CIEF Infection and Treatment, Beijing, China, “The Clinical Application of SICD”, 2019.
Tse H.F., Invited Speaker, Asia Pacific Heart Rhythm Society Session, Taipei, Taiwan “What are the Surprising Findings in the Real World Data of NOACs?,” Real World Status of Subcutaneous-ICD” “Managing your Asian High Risk Patients with NVAF”, 2018.
Tse H.F., Invited Speaker, China International Pacing Summit (CIPS), Boao, China,” Latest Update on SICD,” Increasing CRT Response by Dynamic AV Optimization”, 2019.
Tse H.F., Invited Speaker, TW SPNVAF Masterclass, Taipei, Taiwan “Where are we in Asia in terms of AF Mgt?, “S-ICD System Overview’, 2019.
Tse H.F., Invited Speaker, Update in Cardiology 2018 Seoul, Korea,” The subclinical AF”, “How to detect subclinical AF And reduce the risk of stroke”, 2018.
Tse H.F., Invited Speaker,23rd Asesan Federation of Cardiology Congress, Bangkok, Thailand,“ NOAC and warfarin Asian Population”, 2018.
Tse H.F., Invited Speaker,The 13th Biennial Congress of Chinese Society of Pacing and Electrophysiology, Nanjing, China,” 成人先天性心脏病房性心律失常的高密度标测及消融”, 2018.
Tse H.F., Invited Speaker,國際再生醫療論壇Taipei, Taiwan, “ Human Pluripotent Stem Cells Derived Mesenchymal Stem Cells as Novel Therpay for Treatment of Cardiovascular Diseases”, 2019.
Tse H.F., Speaker, Asia Pacific Heart Rhythm Society Scientific Session, Bangkok, Thailand, Speaker "Single stroke risk factor: what to do" Speaker" Neuromodulation for heart failure" Moderator: The current roles of subQ ICD . 2019.
Tse H.F., Speaker, Macau Cardiology Association – Annual Scientific Meeting 2019,” Latest update of PCSK9i for use high CV risk patients?, 2019.
WANG Y., Liu H.N., Zhen Z., Yiu K.H., Tse H.F., Zhang C., Pelekos G. and Jin L., Periodontal treatment increases circulating EPC counts in patients with T2DM, Journal of Dental Research. 2018, 97 (Spec Iss B): 1114.
WANG Y., Zhen Z., Liu H.N., Lai I.A., Pelekos G., Tse H.F., Yiu K.H. and Jin L., Periodontitis links to exacerbation of myocardial dysfunction in subjects with type 2 diabetes, Journal of Periodontal Research. 2019, 54: 339-348.
Wong Y.K., Cheung Y.Y., Tang S.M., Au K.W., Hai S.H.J.J., Lee C.H.P., Lau G.K.K., Cheung B.M.Y., Sham P.C., Xu A., Lam K.S.L. and Tse H.F., Age-Biomarkers-Clinical Risk Factors for Prediction of Cardiovascular Events in Patients With Coronary Artery Disease., Arterioscler Thromb Vasc Biol. American Heart Association, Inc., 2018, 38: 2519-2527.
Wu M., Chen Y., Au T.W.K., Chan D., Sit K.Y., Ho K.L., Ho L.M., Lam Y.M., Lau C.P., Chan D.T.M., Tse H.F. and Yiu K.H., Predictive value of acute kidney injury for major adverse cardiovascular events following tricuspid annuloplasty: A comparison of three consensus criteria, Journal of Cardiology. 2018, 72: 247-254.
Zhan X.Z., Liu F.Z., Guo H.M., Liao H.T., Fang X.H., Liu J., Deng H., Huang H.L., Hai S.H.J.J., Tse H.F., Li Y.Q., Xue Y.M. and Wu S.L., Characteristics, Mechanism and Long-Term Ablation Outcome of Atrial Tachycardias After Mitral Valvular Surgery and Concomitant Cox-MAZE IV Procedure., International Heart Journal. 2019, 60(1): 71-77.
yao I.N., Fan X.I.N.G.-.L.I.A.N.G., JIANG D., Zhang Y., Li X.I.N., Xu Z.H.I.N.-.B.I.N., fANG S.H.U.-.B.I.N., CHIU S.I.N.M.I.N.G., Tse H.F., Lian Q. and Fu Q.L., Connexin 43-Mediated Mitochondrial Transfer of iPSC-MSCs Alleviates Asthma Inflammation, Stem Cell Reports. 2018, 11: 1120-1135.


Researcher : Tse MYM

List of Research Outputs

Tsang C.O.A., Lau K.K., Tsang C.P., Tse M.Y.M., Lee R. and Lui W.M., Severity of intracranial carotid artery calcification in intracranial atherosclerosis-related occlusion treated with endovascular thrombectomy, Clinical Neurology and Neurosurgery. 2018, 174: 214-216.


Researcher : Tso AWK

Project Title:A population-based prospective study to investigate the associations of obesity and adipokines with the incidence of cardiovascular disease and cancer
Investigator(s):Tso AWK, Cheung BMY, Lam KSL, Lam TH, Tse HF, Wat NMS
Department:Medicine
Source(s) of Funding:Health and Health Services Research Fund - Full Grants
Start Date:12/2008


Project Title:Adipocyte fatty acid-binding protein – an adipocytokine with a role in diabetic nephropathy ?
Investigator(s):Tso AWK, Lam KSL, Chan DTM, Xu A
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:06/2009




Researcher : WANG Y

List of Research Outputs

WANG Y., Lee Y.K.M., Mak J.C.W. and Ip M.S.M., Low-Frequency Intermittent Hypoxia Suppresses Subcutaneous Adipogenesis and Induces Macrophage Polarization in Lean Mice, Diabetes Metab J. 2019.


Researcher : WONG YK

List of Research Outputs

CHEN S., XU X., Lau G.K.K., Li L.S.W., WONG Y.K., Yau C., Mak H.K.F., Chan Q., Chang H.C.C. and Hui S.K., The association between functional brain network and functional outcome after acute ischemic stroke, The 26th Annual Meeting of the International Society for Magnetic Resonance in Medicine. 2019, 3895.
Wong Y.K., Cheung Y.Y., Tang S.M., Au K.W., Hai S.H.J.J., Lee C.H.P., Lau G.K.K., Cheung B.M.Y., Sham P.C., Xu A., Lam K.S.L. and Tse H.F., Age-Biomarkers-Clinical Risk Factors for Prediction of Cardiovascular Events in Patients With Coronary Artery Disease., Arterioscler Thromb Vasc Biol. American Heart Association, Inc., 2018, 38: 2519-2527.


Researcher : Wan Y

List of Research Outputs

Lee C.H.P., Chan R.S.M., Wan Y., Woo Y.C., Cheung Y.Y., Fong H.Y., Cheung B.M.Y., Lam T.H., Janus E., Woo J. and Lam K.S.L., Dietary Intake of Anti-Oxidant Vitamins A, C, and E Is Inversely Associated with Adverse Cardiovascular Outcomes in Chinese—A 22-Years Population-Based Prospective Study, Nutrients. 2018, 10: 1664.


Researcher : Wang AYM

Project Title:An epidemiologic survey of vitamin D deficiency in Chinese patients with moderate to severe chronic kidney disease
Investigator(s):Wang AYM, Kwan CW, Lai KN
Department:Medicine
Source(s) of Funding:Health and Health Services Research Fund - Full Grants
Start Date:07/2008


Project Title:Providing intravenous paricalcitol treatment to the sick and poor chronic hemodialysis patients with severe secondary hyperparathyroidism resistant to existing vitamin D analogs
Investigator(s):Wang AYM
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:08/2010
Completion Date:02/2019


List of Research Outputs

Floege J., Barbour S.J., Cattran D.C., Hogan J.J., Nachman P.H., Tang S.C.W., Wetzels J.F.M., Cheung M., Wheeler D.C., Winkelmayer W.C., Rovin B.H., Adler S.G., Alpers C.E., Ayoub I., Bagga A., Barratt J., Caster D.J., Chan D.T.M., Chang A., Choo J.C.J., Cook H.T., Coppo R., Fervenza F.C., Fogo A.B., Fox J.G., Gibson K.L., Glassock R.J., Harris D., Hodson E.M., Hoxha E., Iseki K., Jennette J.C., Jha V., Johnson D.W., Kaname S., Katafuchi R., Kitching A.R., Lafayette R.A., Li P.K.T., Liew A., Lv J., Malvar A., Maruyama S., Mejía-Vilet J.M., Moeller M.J., Mok C.C., Nester C.M., Noiri E., O'Shaughnessy M.M., Özen S., Parikh S.M., Park H.C., Peh C.A., Pendergraft W.F., Pickering M.C., Pillebout E., Radhakrishnan J., Rathi M., Roccatello D., Ronco P., Smoyer W.E., Tesař V., Thurman J.M., Trimarchi H., Vivarelli M., Walters G.D., Wang A.Y.M. and Wenderfer S.E., Management and treatment of glomerular diseases (part 1): conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference, Kidney International. 2019, 95: 268-280.


Researcher : Wang B

List of Research Outputs

CHEONG L.Y., Wang B., Shu L., WU X., Hoo R.L.C. and Xu A., Absence of inguinal lymph nodes impairs the browning of subcutaneous white adipose tissue in mice , 2018 FASEB Science Research Conferences - Immunological Aspects of Metabolic Syndrome . 2018.
CHEONG L.Y., Wang B., Shu L., Wu X., Hoo R.L.C. and Xu A., Absence of inguinal lymph nodes impairs the browning of subcutaneous white adipose tissue in mice, FASEB Science Research Conferences, 10-15 Aug 2018, Snowmass, CO. 2018.
LIU Z., JIN L., Yang J.K., Wang B., Wu K.K., Hallenborg P., Xu A. and Cheng K.K., The Dysfunctional MDM2-p53 Axis in Adipocytes Contributes to Ageing Related Metabolic Complications by Induction of Lipodystrophy, Diabetes. 2018, db180684.
Pan Y., Wang B., Zheng J., Xiong R., Fan Z., Ye Y., Zhang S., Li Q., Gong F., Wu C., Lin Z., Li X. and Pan X., Pancreatic Fibroblast Growth Factor 21 Protects Against Type 2 Diabetes In Mice By Promoting Insulin Expression And Secretion In A Pi3k/akt Signaling-dependent Manner., Journal of Cellular and Molecular Medicine. 2019.
Wang B., Lin H., Li X., Lam K.S.L., Xu A. and Cheng K., APPL2 deficiency suppresses glucose-stimulated insulin secretion by disrupting F-actin remodeling in pancreatic β cells, 2018 Asia Islet Biology & Incretin Symposium. 2018.
Wang B. and Cheng K., Hypothalamic AMPK as a Mediator of Hormonal Regulation of Energy Balance, International Journal of Molecular Sciences. 2018.


Researcher : Wang J

Project Title:Characterization of the interaction between XAF1 and FHL2 in carcinogenesis and differentiation of gastrointestinal cancers
Investigator(s):Wang J, Wong CYB
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:01/2008


Project Title:Elucidation of the role of Sp1 in maintaining the survival and renewal of colon cancer stem cells
Investigator(s):Wang J, Wong CYB
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:04/2009




Researcher : Wang J.

Project Title:Characterization of the interaction between XAF1 and FHL2 in carcinogenesis and differentiation of gastrointestinal cancers
Investigator(s):Wang J, Wong CYB
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:01/2008


Project Title:Elucidation of the role of Sp1 in maintaining the survival and renewal of colon cancer stem cells
Investigator(s):Wang J, Wong CYB
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:04/2009




Researcher : Wong B.C.Y.

Project Title:Effect of XAF1 gene on tumor growth in gastric and colon cancer
Investigator(s):Wong CYB, Tu S
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:01/2003


Project Title:Role of Bcl-2 family proteins in non-steroidal anti-inflammatory drug-induced apoptosis of gastric cancer
Investigator(s):Wong CYB, Xia HHX
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:02/2004




Researcher : Wong BCY

Project Title:Effect of XAF1 gene on tumor growth in gastric and colon cancer
Investigator(s):Wong CYB, Tu S
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:01/2003


Project Title:Role of Bcl-2 family proteins in non-steroidal anti-inflammatory drug-induced apoptosis of gastric cancer
Investigator(s):Wong CYB, Xia HHX
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:02/2004




Researcher : Wong CM

Project Title:Coupling of nuclear RNA surveillance with splicing
Investigator(s):Wong CM, Chen C
Department:Medicine
Source(s) of Funding:National Natural Science Foundation of China (NSFC) - General Program
Start Date:01/2013




Researcher : Wong DKH

List of Research Outputs

Fung J.Y.Y., Wong D.K.H., Tanaka Y., Lo C.L.R., Wong C.L.T., Chok K.S.H., Chan A.C.Y., Cheung T.T., Dai W.C., Ng K.C.K., Ng K.T.P., Man K., Ng I.O.L., Seto W.K.W., Lai C.L., Yuen R.M.F. and Lo C.M., Quantitative hepatitis B surface antigen in predicting recurrence of hepatitis B-related hepatocellular carcinoma after liver transplantation, Hepatoma Research. 2018, 4: 62.
Gane E.J., Locarnini S., Lim T.H., Strasser S., Sievert W., Cheng W., Thompson A., Given B., Schluep T., Hamilton J., Li Z., Cloherty G., Wong D.K.H., Schwabe C., Jackson K., Ferrari C., Lai C.L., Gish R.G. and Yuen R.M.F., First results with rna interference (rnai) in chronic hepatitis b (chb) using ARO-HBV. Hepatology 2018; 68(6): 1463A-1463A, Hepatology. 2018, 68(6): 1463A-1463A.
Hung F.N.I., Wong D.K.H., Seto W.K.W., Fung J.Y.Y., Yuen K.Y. and Yuen R.M.F., A Double-Blind Randomized Controlled Trial of Intradermal Hepatitis B Vaccination with Topical Imiquimod in Subjects with Occult Hepatitis B Infection, HEPATOLOGY. WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2018, 68: 255A-256A.
LIU F., ZHANG S., Huang F.Y., Wong D.K.H., Mak L.Y., Cheung K.S.M., Lai C.L., Yuen R.M.F. and Seto W.K.W., Characterization of regulatory T cells and the role of PD-1 and TNF-alpha in spontaneous hepatitis B surface antigen seroclearance in chronic hepatitis B, JOURNAL OF HEPATOLOGY. ELSEVIER SCIENCE BV PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, 2019, 70: E454-E455.
LIU F., ZHANG S., Huang F.Y., Wong D.K.H., Mak L.Y., Cheung K.S.M., Lai C.L., Yuen R.M.F. and Seto W.K.W., Characterization of regulatory T cells and the role of PD-1 and TNF-alpha in spontaneous hepatitis B surface antigen seroclearance in chronic hepatitis B, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2019, 701: E454-455.
LIU F., Seto W.K.W., Wong D.K.H., Huang F.Y., Cheung K.S.M., Mak L.Y., Sharma R., ZHANG S., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Plasma fibronectin levels identified via quantitative proteomics profiling predicts hepatitis B surface antigen seroclearance in chronic hepatitis B, The Journal of Infectious Diseases. 2019, 220(6): 940-950.
Liu F., Seto W.K.W., Wong D.K.H., Huang F.Y., Mak L.Y., Cheung K.S.M., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Serum Fibronectin Levels Identified Via Proteomics Profiling Predict Spontaneous Hepatitis B Surface Antigen Seroclearance in Chronic Hepatitis B, HEPATOLOGY. WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2018, 68: 1185A-1186A.
Liu S.H.K., Seto W.K.W., Lau E.H.Y., Wong D.K.H., Lam Y.F., Cheung K.S.M., Mak L.Y., Ko K.L., To W.P., Law M.W.K., Wu J.T.K., Lai C.L. and Yuen R.M.F., A territory-wide prevalence study on blood-borne and enteric viral hepatitis in Hong Kong, The Journal of Infectious Diseases. 2019, 219(12): 1924-1933.
Mak L.Y., Lee C.H.P., Cheung K.S.M., Wong D.K.H., LIU F., Hui R.W., Fung J.Y.Y., Xu A., Lam K.S.L., Yuen R.M.F. and Seto W.K.W., Association of adipokines with hepatic steatosis and fibrosis in chronic hepatitis B patients on long‐term nucleoside analogue, Liver International. 2019, 39(7): 1217-1225.
Mak L.Y., Wong D.K.H., Seto W.K.W., Ning Q., Cheung K.S.M., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Correlation of serum Mac-2-binding protein glycosylation isomer (M2BPGi) and liver stiffness in chronic hepatitis B infection, Hepatology International. 2019, 13(2): 148-156.
Mak L.Y., Seto W.K.W., Hui R.W., Fung J.Y.Y., Wong D.K.H., Lai C.L. and Yuen R.M.F., Fibrosis evolution in chronic hepatitis B E‐antigen negative patients across a 10‐year interval, Journal of Viral Hepatitis. 2019, 26(7): 818-827.
Mak L.Y., Wong D.K.H., Seto W.K.W., Cheung K.S.M., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., High Serum Mac-2-binding protein glycosylation isomer (M2BPGi) level was associated with incident hepatocellular carcinoma in entecavir-treated chronic hepatitis B patients, Hepatology. 2018, 68: 864A-864A.
Mak L.Y., To W.P., Wong D.K.H., Fung J.Y.Y., LIU F., Seto W.K.W., Lai C.L. and Yuen R.M.F., Serum Mac-2 binding protein glycosylation isomer level predicts hepatocellular carcinoma development in E-negative chronic hepatitis B patients, World Journal of Gastroenterology. 2019, 25: 1398-1408.
Mak L.Y., Ko M., To E., Wong D.K.H., Ma J.H.C., Hui T.L.Y., Seto W.K.W., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Serum Mac-2-binding protein glycosylation isomer and risk of hepatocellular carcinoma in entecavir-treated chronic hepatitis B patients, Journal of Gastroenterology and Hepatology. 2019.
Seto W.K.W., Chan S.Y.T., Hwang Y.Y.G., Mak L.Y., Wong D.K.H., Fung J.Y.Y., Liu S.H.K., Cheung K.S.M., Lai C.L., Kwong Y.L. and Yuen R.M.F., Monitoring and Treatment of Patients Undergoing Immunotherapy With Anti-CD20 Who are Exposed to HBV, Clinical Gastroenterology and Hepatology. 2018, 17(7): 1410-1412.
Seto W.K.W., Liu S.H.K., Mak L.Y., Cheung K.S.M., Wong D.K.H., Liu F., Fung J.Y.Y., Lai C.L. and Yuen R.M.F., Treatment Cessation in Chronic Hepatitis B: Predicting Off-Treatment Durability Via Combination of Viral Markers, HEPATOLOGY. WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2018, 68: 248A-249A.
Wong D.K.H., Cheng C.Y.S., Mak L.Y., To W.P., Lo C.L.R., Cheung T.T., Seto W.K.W., Fung J.Y.Y., Man K., Lai C.L. and Yuen R.M.F., Among Patients with Undetectable Hepatitis B Surface Antigen and Hepatocellular Carcinoma, a High Proportion Has Integration of HBV DNA into Hepatocyte DNA and No Cirrhosis, Clinical Gastroenterology and Hepatology. 2019.
Wong D.K.H., Assessment of Liver Fibrosis Stages and Its Clinical Use, 澳門醫務衛生界聯合 總會 第十屆理監事就 職典禮 暨 專題學術會 議, 2019.
Wong D.K.H., Editorial Board Member, Scientific Reports. 2019.
Wong D.K.H., Cheng C.Y.S., Mak L.Y., To W.P., Cheung T.T., Seto W.K.W., Fung J.Y.Y., Man K., Lai C.L. and Yuen R.M.F., High Rate of HBV DNA Integration in Hepatocellular Carcinoma Patients with Occult Hepatitis B Infection, HEPATOLOGY. WILEY 111 RIVER ST, HOBOKEN 07030-5774, NJ USA, 2018, 68: 331A-331A.
Wong D.K.H., Cheng C.Y.S., Mak L.Y., To W.P., Cheung T.T., Seto W.K.W., Fung J.Y.Y., Man K., Lai C.L. and Yuen R.M.F., Integration of HBV DNA near cancer-related genes in HBsAg-negative hepatocellular carcinoma patients, JOURNAL OF HEPATOLOGY. ELSEVIER SCIENCE BV PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, 2019, 70: E269-E269.
Wong D.K.H., Cheng C.Y.S., Mak L.Y., To W.P., Cheung T.T., Seto W.K.W., Fung J.Y.Y., Man K., Lai C.L. and Yuen R.M.F., Integration of HBV DNA near cancer-related genes in HBsAg-negative hepatocellular carcinoma patients, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2019, 701: E269.
Wong D.K.H., Role of Microbiology Laboratory in Cancer Diagnosis, Central Commissioned Training Program for Medical Laboratory Technologists 2018/19 . 2018.
Yuen R.M.F., Liu S.H.K., Seto W.K.W., Wong D.K.H., Wong S.Y., Cheung K.S.M., Mak L.Y.L., Ko K.L.M., To W.P.E., Yuen J.C.H., Wu C.H., Cheng C.T.K., Wu J.T.K. and Lau E.H.Y., Faculty Knowledge Exchange Award, HKU LKS Faculty of Medicine. 2019.
Yuen R.M.F., Locarnini S., Lim T.H., Strasser S., Sievert W., Cheng W., Thompson A., Given B., Schluep T., Hamilton J., Cloherty G., Wong D.K.H., Schwabe C., Jackson K., Ferrari C., Lai C.L., Gish R.G. and Gane E., Short term RNA interference therapy in chronic hepatitis B using JNJ-3989 brings majority of patients to HBsAg < 100 IU/ml threshold, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2019, 701: E51-52.
ZHANG S., LIU F., Huang F.Y., Wong D.K.H., Lai C.L., Yuen R.M.F. and Seto W.K.W., The role of Paneth cells in the pathogenesis of non-alcoholic fatty liver disease: A potential gut microbiota-associated mechanism, JOURNAL OF HEPATOLOGY. ELSEVIER SCIENCE BV PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS, 2019, 70: E553-E553.


Researcher : Wong HYH

List of Research Outputs

Chiu W.Y.J., Leung R.C.Y., Tang Y.F.V., Cheuk W.Y.I., Lo L.F., Kwok G.W., Wong H.Y.H., Suen T.K.D., Cheung P., Wong T.T., Yau T.C.C. and Kwong A., Changing pattern of recurrences in patients with early HER2-positive breast cancer receiving neoadjuvant chemotherapy in the era of dual anti-HER2 therapy, Postgraduate Medical Journal. 2019, 95: 155-161.


Researcher : Wong KL

List of Research Outputs

Huang D., Cheng Y., Wong Y.T.A., Yung S.A., Tam C.C., Chan K.W.K., Lam C.C.S., Yiu K.H., Hai S.H.J.J., Lau C.P., Chan E.W.Y., Chiang C.E., Wong K.L., Cheung T.T., Cheung B.M.Y., Feng Y.Q., Tam N., Chen J.Y., Yue W.S., Hu H.X., Chen L., Tse H.F., Chan P.H.M. and Siu D.C.W., Thrombolysis in myocardial infarction risk score for secondary prevention of recurrent cardiovascular events in a real-world cohort of post-acute myocardial infarction patients, Circulation. 2019, 83(4): 809-817.


Researcher : Wong KY

List of Research Outputs

Wong K.Y., YAO Q., Yuan L., LI Z., Ma E.S.K. and Chim J.C.S., Frequent functional activation of RAS signalling not explained by RAS/RAF mutations in relapsed/refractory multiple myeloma, Scientific Reports. 2018, 8.


Researcher : Wong LYF

Project Title:Involvement of NF-κB and cAMP-dependent protein kinase pathways in adrenomedullin-induced cytokine responses in macrophages
Investigator(s):Wong LYF, Cheung BMY
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2004


Project Title:Mechanism of the modulation of cytokine responses by adrenomedullin and adrenomedullin binding protein-1 in macrophages: a novel pathway in sepsis with therapeutic implications
Investigator(s):Wong LYF, Cheung BMY
Department:Medicine
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:10/2006




Researcher : Wong SY

List of Research Outputs

Yuen R.M.F., Liu S.H.K., Seto W.K.W., Wong D.K.H., Wong S.Y., Cheung K.S.M., Mak L.Y.L., Ko K.L.M., To W.P.E., Yuen J.C.H., Wu C.H., Cheng C.T.K., Wu J.T.K. and Lau E.H.Y., Faculty Knowledge Exchange Award, HKU LKS Faculty of Medicine. 2019.


Researcher : Wong WLD

List of Research Outputs

Chan K.W., Kwong A.S.K., Chan G.C.W., Leung C.P.S., Yiu W.H., Lui S.L., Ip T.P., Cowling B.J., Wong W.L.D., LI B., LI Y., Feng Y., Chan L.Y.Y., Leung J.C.K., Tan K.C.B., Wong C.W.V., Lai K.N. and Tang S.C.W., Best Poster Award, Good Practice In Traditional Chinese Medicine Research Association. 2018.
Chan K.W., Kwong A.S.K., Chan G.C.W., Leung C.P.S., Yiu W.H., Lui S.L., Ip T.P., Cowling B.J., Wong W.L.D., LI B., LI Y., Feng Y., Chan Y.Y., Leung J.C.K., Tan K.C.B., Wong C.W.V., Lai K.N. and Tang S.C.W., Semi-individualised Chinese Medicine Treatment for Diabetic Kidney Disease – From users’ perspectives to SCHEMATIC trial interim result and potential mechanisms, Advances in Integrative Medicine (International Congress on Complementary Medicine Research). 2019, 6: S12.


Researcher : Wong Y

List of Research Outputs

Tan K.C.B., Cheung C.L., Lee C.H.A., Lam J.K.Y., Wong Y. and Shiu S.W.M., Galectin-3 and risk of cardiovascular events and all-cause mortality in type 2 diabetes, Diabetes Metab Res Rev. 2019, 35(2): e3093.


Researcher : Wong YK

List of Research Outputs

CHEN S., XU X., Lau G.K.K., Li L.S.W., WONG Y.K., Yau C., Mak H.K.F., Chan Q., Chang H.C.C. and Hui S.K., The association between functional brain network and functional outcome after acute ischemic stroke, The 26th Annual Meeting of the International Society for Magnetic Resonance in Medicine. 2019, 3895.
Wong Y.K., Cheung Y.Y., Tang S.M., Au K.W., Hai S.H.J.J., Lee C.H.P., Lau G.K.K., Cheung B.M.Y., Sham P.C., Xu A., Lam K.S.L. and Tse H.F., Age-Biomarkers-Clinical Risk Factors for Prediction of Cardiovascular Events in Patients With Coronary Artery Disease., Arterioscler Thromb Vasc Biol. American Heart Association, Inc., 2018, 38: 2519-2527.


Researcher : Wong YTA

List of Research Outputs

Huang D., Cheng Y., Wong Y.T.A., Yung S.A., Tam C.C., Chan K.W.K., Lam C.C.S., Yiu K.H., Hai S.H.J.J., Lau C.P., Chan E.W.Y., Chiang C.E., Wong K.L., Cheung T.T., Cheung B.M.Y., Feng Y.Q., Tam N., Chen J.Y., Yue W.S., Hu H.X., Chen L., Tse H.F., Chan P.H.M. and Siu D.C.W., Thrombolysis in myocardial infarction risk score for secondary prevention of recurrent cardiovascular events in a real-world cohort of post-acute myocardial infarction patients, Circulation. 2019, 83(4): 809-817.


Researcher : Wong YYS

List of Research Outputs

CHOW J.X., Lam K.Y.I., Wong Y.Y.S., Lau W.C.S. and Chan V.S.F., Dysregulation of AIM2 inflammasome response in patients with Systemic Lupus Erythematosus, 13th World Immune Regulation Meeting. 2019.


Researcher : Woo YC

List of Research Outputs

Cheung Y.Y., Lee C.H.P., Tang S.M., Xu A., Au K.W., Fong H.Y., Ng K.K., KWOK H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Hai S.H.J.J., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Genetic regulation of Pigment Epithelium-Derived Factor (PEDF): an exome-chip association analysis in Chinese subjects with type 2 diabetes, Diabetes. 2019, 68: 198-206.
Lang H.H.B., Wong C.K.H., Ma E.P.M., Woo Y.C. and Chiu W.H.K., A propensity-matched analysis of clinical outcomes between open thyroid lobectomy and high-intensity focused ultrasound (HIFU) ablation of benign thyroid nodules, Surgery. 2018, 165 (1): 85-91.
Lang H.H.B., Woo Y.C. and Chiu W.H.K., Changes in serum thyroglobulin and antithyroglobulin shortly following high-intensity focused ablation of benign thyroid nodules in patients with positive antithyroglobulin status, International Journal of Hyperthermia. 2018.
Lang H.H.B., Woo Y.C. and Chiu W.H.K., Effect of perithyroidal lignocaine infusion (PLI) to pain experienced during high-intensity focused ultrasound (HIFU) ablation of benign thyroid nodules, European Radiology. 2019, Epub ahead of print.
Lang H.H.B., Woo Y.C. and Chiu W.H.K., High intensity focused ultrasound (HIFU) ablation of benign thyroid nodule is safe and efficacious in patients who continue taking an anti-coagulation or anti-platelet agent in the treatment period, International Journal of Hyperthermia. 2018, Epub ahead of print: 1-5.
Lang H.H.B., Woo Y.C. and Chiu W.H.K., Role of second high-intensity focused ultrasound (HIFU) treatment for unsatisfactory benign thyroid nodules after first treatment, European Radiology. 2018, Epub ahead of print.
Lang H.H.B., Woo Y.C. and Chiu W.H.K., Two sequential applications of high-intensity focused ultrasound (HIFU) ablation for large benign thyroid nodules, European Radiology. 2019, Epub ahead of print.
Lang H.H.B., Woo Y.C. and Chiu W.H.K., Two-year outcomes of single-session high-intensity focused ultrasound (HIFU) treatment in persistent or relapsed Graves' disease, European Radiology. 2019, Epub ahead of print.
Lee C.H.P., Woo Y.C., Lam K.S.L. and Tan K.C.B., Case series of Chinese patients with dysthyroid optic neuropathy: a single centre audit, 5th International Thyroid Eye Disease Symposium, Singapore, Feb 2019.
Lee C.H.P., Cheung Y.Y., Woo Y.C., Lui D.T.W., Yuen M.A.M., Fong H.Y., Chow W.S., Xu A. and Lam K.S.L., Circulating Adipocyte Fatty Acid–Binding Protein Concentrations Predict Multiple Mortality Outcomes among Men and Women with Diabetes, Clinical Chemistry. 2018, clinchem.2018.289157.
Lee C.H.P., Chan R.S.M., Wan Y., Woo Y.C., Cheung Y.Y., Fong H.Y., Cheung B.M.Y., Lam T.H., Janus E., Woo J. and Lam K.S.L., Dietary Intake of Anti-Oxidant Vitamins A, C, and E Is Inversely Associated with Adverse Cardiovascular Outcomes in Chinese—A 22-Years Population-Based Prospective Study, Nutrients. 2018, 10: 1664.
Lee C.H.P., Woo Y.C. and Lam K.S.L., Fighting the Health Challenges of Diabetes in Hong Kong: A Window Into Mainland China, American Journal of Public Health. 2018, 108: 1623-1624.
Lee C.H.P., Cheung Y.Y., Woo Y.C., Lui D.T.W., Yuen M.A.M., Fong H.Y., Chow W.S., Xu A. and Lam K.S.L., Prospective associations of circulating adipocyte fatty acid-binding protein levels with risks of renal outcomes and mortality in type 2 diabetes, Diabetologia. 2019, 62: 169-177.
Lee C.H.P., Woo Y.C., Lam K.Y.J., Lee C.H.A., Lam K.S.L. and Tan K.C.B., The effects of insulin treatment on circulating ketone levels in patients with type 2 diabetes on sodium-glucose co-transporter 2 inhibitors, American Diabetes Association 79th Scientific Sessions, San Francisco, June 2019.
Lui D.T.W., Woo Y.C., Chow W.S., Lee C.H.P., Lee C.H.A., Leung E.K.H., Tan K.C.B., Lam K.S.L. and Lam K.Y.J., Glycogenic hepatopathy as an unusual etiology of deranged liver function in a patient with type 1 diabetes, Medicine. 2019, 98: e15296.


Researcher : Wu CH

List of Research Outputs

Yuen R.M.F., Liu S.H.K., Seto W.K.W., Wong D.K.H., Wong S.Y., Cheung K.S.M., Mak L.Y.L., Ko K.L.M., To W.P.E., Yuen J.C.H., Wu C.H., Cheng C.T.K., Wu J.T.K. and Lau E.H.Y., Faculty Knowledge Exchange Award, HKU LKS Faculty of Medicine. 2019.


Researcher : Wu M

List of Research Outputs

CHEN Y., Liu Y., Seto W.K.W., Wu M., YU Y., Lam Y.M., Au W.K., Chan D., Sit K.Y., Ho L.M., Tse H.F. and Yiu K.H., Prognostic Value of Hepatorenal Function By Modified Model for End‐stage Liver Disease (MELD) Score in Patients Undergoing Tricuspid Annuloplasty, Journal of the American Heart Association. 2018, 7: e009020.
Chan Y.H., Ngai M.C., Chen Y., Wu M., YU Y., ZHEN Z., Lai K.W.H., Cheung T.T., Ho L.M., Chung H.Y., Lau W.C.S., Tse H.F. and Yiu K.H., Cumulative Rheumatic Inflammation Modulates the Bone–Vascular Axis and Risk of Coronary Calcification, Journal of the American Heart Association. 2019, 8.
Chan Y.H., Ngai M.C., Chen Y., Wu M., YU Y., ZHEN Z., Lai K.W.H., Cheung T.T., Ho L.M., Chung H.Y., Lau W.C.S., Lau C.P., Tse H.F. and Yiu K.H., Osteogenic circulating endothelial progenitor cells are linked to electrocardiographic conduction abnormalities in rheumatic patients, Annals of Noninvasive Electrocardiology. 2019, e12651.
Chen Y., Liu Y., Seto W.K.W., Wu M., YU Y., Lam Y.M., Au T.W.K., Sit K.Y., Ho L.M., Tse H.F. and Yiu K.H., Prognostic Value of Hepatorenal Function By Modified Model for End-stage Liver Disease (MELD) Score in Patients Undergoing Tricuspid Annuloplasty, Journal of the American Heart Association. 2018, 7(14): 1-11.
Chen Y., Liu Y., Wu M., Lam Y.M., Ho L.M., Lau C.P., Au T.W.K., Tse H.F. and Yiu K.H., Prognostic value of tricuspid valve geometry and leaflet coaptation status in patients undergoing tricuspid annuloplasty: a three-dimensional echocardiography study, PCR Tokyo Valves 2019.
Wu M., Chen Y., Au T.W.K., Chan D., Sit K.Y., Ho K.L., Ho L.M., Lam Y.M., Lau C.P., Chan D.T.M., Tse H.F. and Yiu K.H., Predictive value of acute kidney injury for major adverse cardiovascular events following tricuspid annuloplasty: A comparison of three consensus criteria, Journal of Cardiology. 2018, 72: 247-254.
ZHAO D., Yiu K.H., Wu M., Yu S.Y., Pelekos G. and Jin L., Is severe periodontitis a pre-indicator of abnormal systemic conditions?, Journal of Dental Research. 2019, 98 (Spec Iss A): 0361.


Researcher : Wu X

List of Research Outputs

CHEONG L.Y., Wang B., Shu L., Wu X., Hoo R.L.C. and Xu A., Absence of inguinal lymph nodes impairs the browning of subcutaneous white adipose tissue in mice, FASEB Science Research Conferences, 10-15 Aug 2018, Snowmass, CO. 2018.


Researcher : XU S

List of Research Outputs

Lam S.K., Yan S., XU S., U K.P., Cheng P.N. and Ho J.C.M., Endogenous arginase 2 as a potential biomarker for PEGylated arginase 1 treatment in xenograft models of squamous cell lung carcinoma , Oncogenesis. 2019, 8: 18.
Lam S.K., U K.P., Li Y.V., XU S., Cheng P.N. and Ho J.C.M., Inhibition of ornithine decarboxylase 1 facilitates pegylated arginase treatment in lung adenocarcinoma xenograft models, Oncology Reports. 2018.
Lam S.K., Yan S., XU S. and Ho J.C.M., Targeting polyamines as potential adjuvant therapy in malignant pleural mesothelioma xenograft models, IASLC 19th World Conference on Lung Cancer. 2018.
Lam S.K., Yan S., XU S. and Ho J.C.M., Targeting polyamines as potential adjuvant therapy in malignant pleural mesothelioma xenograft models, 24th Medical Research Conference. Medical Journal, 2019, 25: 26.
XU S., Lam S.K., Cheng P.N. and Ho J.C.M., Recombinant human arginase induces apoptosis via oxidative stress and cell cycle arrest in small cell lung cancer, Cancer Science. 2018, Epub ahead of print.


Researcher : Xia HHX

Project Title:Homeobox genes in gastric carcinogenesis: an in vivo and in vitro study
Investigator(s):Xia HHX, Wong CYB
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:01/2003


Project Title:Role of cyclooxygenase in helicobacter pylori-induced gastric carcinogenesis
Investigator(s):Xia HHX, Wong CYB
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:02/2004


Project Title:Role of macrophage migration inhibitory factor in Helicobacter pylori-induced gastric carcinogenesis
Investigator(s):Xia HHX, Wong CYB
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:05/2005




Researcher : Xian J

List of Research Outputs

Ho W.L., Leung C.T.G., Liu H., Pang S.Y.Y., Lam C.S.C., Xian J., Li L., Kung M.H.W., Ramsden D.B. and Ho S.L., Age-dependent accumulation of oligomeric SNCA/α-synuclein from impaired degradation in mutant LRRK2 knockin mouse model of Parkinson disease: role for therapeutic activation of chaperone-mediated autophagy (CMA), Autophagy. 2019, 1-24.


Researcher : Xiong J

Project Title:2008 NCRI Cancer Conference Growth inhibitory effect of 5-aza-2'-deoxycytidine on cancer cells is independent of p16 ink4a and p14ARF
Investigator(s):Xiong J
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2008




Researcher : Xu A

Project Title:Molecular mechanism underlaying the pathogenesis of type 2 diabetes
Investigator(s):Xu A
Department:Medicine
Source(s) of Funding:Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:05/2007


Project Title:Genetic and pathogenic pathways leading to type 2 diabetes Mellitus
Investigator(s):Xu A
Department:Medicine
Source(s) of Funding:Matching Fund for National Key Basic Research Development Scheme (973 Projects)
Start Date:05/2011


Project Title:71th Scientific Sessions of the American Diabetes Association Genetic Inactivation of Toll-Like Receptor 4 Alleviates Diet-Induced Nonalcoholic Steatohepatitis by Inhibiting Reactive Oxygen Species-Evoked Activation of X-box Binding Protein-1 in ApoE-Deficient Mice
Investigator(s):Xu A
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:06/2011


Project Title:Physical exercise promotes vascular health: impact of mechano-transduction and novel endothelium-derived regulators
Investigator(s):Xu A
Department:Medicine
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:06/2013


Project Title:Fatty acid binding protein-4 as a mediator of autoimmune diabetes: from molecular mechanism to clinical significance
Investigator(s):Xu A, Lam KSL
Department:Medicine
Source(s) of Funding:NSFC/RGC Joint Research Scheme
Start Date:01/2015
Completion Date:12/2018


Project Title:FGF21 resistance as a potential mediator of systemic insulin resistance and type 2 diabetes
Investigator(s):Xu A, Lam KSL, Chan YCC
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:04/2015


Project Title:Development of innovative chemiluminescent immunoassays for diabetes and its cardiovascular complications
Investigator(s):Xu A, Cheung BMY, Zhang J, Zhou P, Wang Y, Choi L
Department:Medicine
Source(s) of Funding:Matching Grant for Joint Research
Start Date:04/2015


Project Title:A Multi-disciplinary Approach to Investigate Vascular Dysfunction in Obesity and Diabetes: From Molecular Mechanism to Therapeutic Intervention
Investigator(s):Xu A, Cheng KY, Lam KSL, Vanhoutte PMGR, Wang Y, Woo WHC, Wu EX
Department:Medicine
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:06/2015


Project Title:2015 51st EASD Annual Meeting ; Adiponectin is required for adaptive thermogenesis by enhancing the browning of white adipose tissues in mice
Investigator(s):Xu A
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:09/2015


Project Title:Frontiers in Immunometabolism
Investigator(s):Xu A
Department:Medicine
Source(s) of Funding:Croucher Advanced Study Institute
Start Date:11/2015


Project Title:Development of Innovative Chemiluminescent Immunoassays for Diabetes and its Cardiovascular Complications
Investigator(s):Xu A, Cheung BMY, Zhang J, Zhou P, Wang Y, Choi L
Department:Medicine
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:11/2015


Project Title:Neutrophil serine proteases as a potential mediator of insulitis in autoimmune diabetes
Investigator(s):Xu A
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2016
Completion Date:12/2019


Project Title:Deciphering the molecular mechanism of Protein Arginine Methyltransferase (PRMT) 1 in the regulation of hepatic glucose and lipid metabolism
Investigator(s):Xu A, Woo WHC
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:06/2016
Completion Date:12/2019


Project Title:Activation of uncoupling protein-1 as a potential therapeutic strategy for obesity-induced endothelial dysfunction and atherosclerosis
Investigator(s):Xu A
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:06/2016


Project Title:FGF21 as a potential mediator for the anti-depressant effects of physical exercise
Investigator(s):Xu A
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:06/2016


Project Title:Fibroblast growth factor-21 as an Autocrine Regulator of Browning and Adaptive Thermogenesis in Subcutaneous Adipose Tissue
Investigator(s):Xu A, Hui X
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2017


Project Title:Development of an Innovative Immunoturbidimetric Assay (ITA) of Lipocalin-2 (LCN2) for Prognosis and Diagnosis of Diabetes and its Cardiovascular Complications
Investigator(s):Xu A, Zhong L, Zhou P
Department:Medicine
Source(s) of Funding:Seed Fund for Translational and Applied Research
Start Date:06/2017


Project Title:Adiponectin antagonizes dietary obesity-induced metabolic dysfunction via modulation of gut microbiota
Investigator(s):Xu A, Liu Y
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:06/2017


Project Title:Institute of Metabolic Medicine (AoE)
Investigator(s):Xu A
Department:Medicine
Source(s) of Funding:Seed Funding for Strategic Interdisciplinary Research Scheme
Start Date:06/2017


Project Title:A multi-disciplinary study on the beneficial effects of PPARD in physical exercise against diabetic vascular complications: cellular crosstalk and energy metabolism
Investigator(s):Xu A
Department:Medicine
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:06/2017


Project Title:The mechanobiology of obesity
Investigator(s):Xu A, Hui X, Wang B
Department:Medicine
Source(s) of Funding:France/Hong Kong Joint Research Scheme - Travel Grants
Start Date:01/2018


Project Title:UCP1 Independent Mechanisms Mediate the Crosstalk between Brown and White Adipose Tissue to Dissipate Energy
Investigator(s):Xu A, Hui X
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2018


Project Title:A Multi-Channel Oxytherm System for Research into Mitochondria Respiration and Function
Investigator(s):Xu A, Shen J, Chung SK, Hoo RLC, Hui X, Woo WHC
Department:Medicine
Source(s) of Funding:Small Equipment Grant
Start Date:04/2018


Project Title:Hepatic G protein-coupled receptor 110 as a potential therapeutic target to combat obesity and its related metabolic complications
Investigator(s):Xu A, Huang Z
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:06/2018


Project Title:Conversion of white into brown adipocytes as a therapeutic strategy for obesity-related metabolic and vascular complications
Investigator(s):Xu A, Hoo RLC, Hui X, Vanhoutte PMGR, Wang Y, Woo WHC
Department:Medicine
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:06/2018


Project Title:Targeting Neutrophil Serine Proteases for Treatment of Vascular Inflammation and Atherosclerosis
Investigator(s):Xu A, Hui X
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:07/2018


Project Title:2018 Research Output Prize (Faculty of Medicine)
Investigator(s):Xu A
Department:Medicine
Source(s) of Funding:Research Output Prize (in Faculty)
Start Date:12/2018


Project Title:Roles of FGF21 signaling pathways in conferring the beneficial effects of physical exercise on cardiac metabolism and function in diabetic hearts
Investigator(s):Xu A, Xia Z
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2019


Project Title:Establishing an ex vivo isolated working heart system for direct measurement of cardiac function and energy metabolism
Investigator(s):Xu A, Xia Z, Hui X, Hoo RLC, Wang Y, Woo WHC, Shen J, Rong J
Department:Medicine
Source(s) of Funding:Small Equipment Grant
Start Date:04/2019


Project Title:Institute of Metabolic Medicine
Investigator(s):Xu A, Lam KSL, Liu P, Wu EX, Li XD, Vanhoutte PMGR, Wang Y, Macfarlane DJ, Woo WHC, Cheung BMY, Siu MFP, Xia Z, Hoo RLC, Lee CHP, Hui X
Department:Medicine
Source(s) of Funding:Areas of Excellence Scheme
Start Date:05/2019


Project Title:Adipocytes regulates osteogenesis by paracrine and/or endocrine actions.
Investigator(s):Xu A, Liu Z
Department:Medicine
Source(s) of Funding:Seed Fund for Basic Research
Start Date:06/2019


Project Title:An advanced monoclonal antibody platform for biopharmaceutical development, medical diagnosis and precision medicine
Investigator(s):Xu A, Chan KL, Chen Z
Department:Medicine
Source(s) of Funding:Platform Technology Funding
Start Date:06/2019


List of Research Outputs

Baretella O.M., Xu A. and Vanhoutte P.M.G.R., No Protective Effect of Constitutive Activation of AMPK in Endothelial Cells on Vascular Function in Aged Obese Mice but Augmented α1-Adrenergic Contractions in Renal Arteries Reversible by Weight Loss, Journal of Vascular Research. 2018, 189-202.
CHEONG L.Y., Wang B., Shu L., WU X., Hoo R.L.C. and Xu A., Absence of inguinal lymph nodes impairs the browning of subcutaneous white adipose tissue in mice , 2018 FASEB Science Research Conferences - Immunological Aspects of Metabolic Syndrome . 2018.
CHEONG L.Y., Wang B., Shu L., Wu X., Hoo R.L.C. and Xu A., Absence of inguinal lymph nodes impairs the browning of subcutaneous white adipose tissue in mice, FASEB Science Research Conferences, 10-15 Aug 2018, Snowmass, CO. 2018.
CHEUNG J., YIU J.H.C., FUNG W.L., Xu A. and Woo W.H.C., High Fat Diet Protects Against radiation-Induced Damage: a potential benefit from Gut Microbiota, Keystone Symposia on Molecular and Cellular Biology, March 10-14, 2019, Montreal, Quebec, Canada. 2019.
Cheang W., Wong W., Wang L., Cheng C., Lau C., Ma R., Xu A., Wang N., Huang Y. and Tian X., Resveratrol ameliorates endothelial dysfunction in diabetic and obese mice through sirtuin 1 and peroxisome proliferator-activated receptor δ, Pharmacological Research. 2019, 139: 384-394.
Cheung Y.Y., Lee C.H.P., Tang S.M., Xu A., Au K.W., Fong H.Y., Ng K.K., KWOK H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Hai S.H.J.J., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Genetic regulation of Pigment Epithelium-Derived Factor (PEDF): an exome-chip association analysis in Chinese subjects with type 2 diabetes, Diabetes. 2019, 68: 198-206.
Ellie A., Bloksgaard M., Sun W.Y., Yang K., Man W.C.A., Xu A., Irmukhamedov A., . Riber L., Wang Y., De Mey J. and Pablo G., Local enrichment of fatty acid-binding protein 4 in the pericardial cavity of cardiovascular disease patients, PLOS ONE. 2018, 13: e0206802.
FENG J., Chen X., Lu S., LI W., Wang Q., Xu A. and Shen J., Naringin attenuates cerebral ischemia-reperfusion injury through inhibiting peroxynitrite-mediated mitophagy activation, Molecular Neurobiology . 2018, 2018.
Gao C., Chen X., Xu A., Cheng K.Y. and Shen J., Adaptor Protein APPL2 Affects Adult Antidepressant Behaviors and Hippocampal Neurogenesis via Regulating the Sensitivity of Glucocorticoid Receptor, Molecular Neurobiology. 2018, 55: 5537-5547.
Geng L., Liao B., Jin L., Huang Z., Triggle C., Hong D., Zhang J., Huang Y., Lin Z. and Xu A., Exercise Alleviates Obesity-Induced Metabolic Dysfunction via Enhancing FGF21 Sensitivity in Adipose Tissues, In: Stephen Matheson, Cell Reports. Cambridge, Massachusetts, U.S., Cell Press, 2019, 26: 2738-2752.E4.
Guo Y., Man W.C.A., Luo C., Huang Y., Xu A., Vanhoutte P.M.G.R. and Wang Y., SIRT1 prevents age-induced impairment of vasodilator responses by enhancing the expression and activity of soluble guanylyl cyclase, Cardiovascular Research . 2018.
Huang J., Xiao Y., Zheng P., Zhou W., Wang Y., Huang G., Xu A. and Zhou Z., Distinct neutrophil counts and functions in patients with newly diagnosed type 1 diabetes, latent autoimmune diabetes in adults, and type 2 diabetes, Diabetes/Metabolism Research and Reviews. 2018, e3064.
KONJA D., ZHANG P., Luo C., Xu A., Vanhoutte P.M.G.R. and Wang Y., Overexpression of SIRT1 in perivascular adipose tissue enhances vasodilatation and prevents adverse arterial remodeling by modulating the crosstalks between mitochondria and endoplasmic reticulum, 13th MOVD /7th EDH 2019, Rotterdam, The Netherlands, May 20-22, 2019.
LIU Z., JIN L., Yang J.K., Wang B., Wu K.K., Hallenborg P., Xu A. and Cheng K.K., The Dysfunctional MDM2-p53 Axis in Adipocytes Contributes to Ageing Related Metabolic Complications by Induction of Lipodystrophy, Diabetes. 2018, db180684.
Lee C.H.P., Cheung Y.Y., Woo Y.C., Lui D.T.W., Yuen M.A.M., Fong H.Y., Chow W.S., Xu A. and Lam K.S.L., Circulating Adipocyte Fatty Acid–Binding Protein Concentrations Predict Multiple Mortality Outcomes among Men and Women with Diabetes, Clinical Chemistry. 2018, clinchem.2018.289157.
Lee C.H.P., Cheung Y.Y., Woo Y.C., Lui D.T.W., Yuen M.A.M., Fong H.Y., Chow W.S., Xu A. and Lam K.S.L., Prospective associations of circulating adipocyte fatty acid-binding protein levels with risks of renal outcomes and mortality in type 2 diabetes, Diabetologia. 2019, 62: 169-177.
Li H., Wu G., Fang Q., Zhang M., Hui X., Sheng B., Wu L., Bao Y., Li P., Xu A. and Jia W., Fibroblast growth factor 21 increases insulin sensitivity through specific expansion of subcutaneous fat, Nature Communications. 2018, 9.
Liu J.J., Liu S., Choo R.W.M., Wee S.L., Xu A. and Lim S.C., Sex modulates the association of fibroblast growth factor 21 with end-stage renal disease in Asian people with Type 2 diabetes: a 6.3-year prospective cohort study, Diabetic Medicine. 2018, 35: 880-886.
Mak L.Y., Lee C.H.P., Cheung K.S.M., Wong D.K.H., LIU F., Hui R.W., Fung J.Y.Y., Xu A., Lam K.S.L., Yuen R.M.F. and Seto W.K.W., Association of adipokines with hepatic steatosis and fibrosis in chronic hepatitis B patients on long‐term nucleoside analogue, Liver International. 2019, 39(7): 1217-1225.
Pan Y., Hui X., Hoo R.L.C., Ye D., Chan C.Y.C., Feng T., Wang Y., Lam K.S.L. and Xu A., Adipocyte-secreted Exosomal Microrna-34a Inhibits M2 Macrophage Polarization To Promote Obesity-induced Adipose Inflammation, Journal of Clinical Investigation. 2019, 129: 834-849.
Shu L., WU X., CHEONG L.Y., Zhou Z., Hoo R.L.C., Lam K.S.L. and Xu A., FABP4 mediates autoimmune destruction of beta cells by enhancing the crosstalk between innate and adaptive immunity/ Oral presentation, Asia Islet Biology and Incretin Symposium (AIBIS 2018). 2018.
Shu L., Hoo R.L.C. and Xu A., Fabp4 Mediates Autoimmune Diabetes Though Activation On Macrophage And Tissue Resident Memory T Lymphocyte , Shs Young Investigator Symposium & 9th Gwanak Symposium. 2019.
Shu L., Hoo R.L.C. and Xu A., Fabp4 Promotes Autoimmune Diabetes Through Activation On Macrophages And Tissue Resident Memory T Lymphocytes, Shs Young Investigator Symposium. 2019.
Shu L., Hoo R.L.C. and Xu A., Fabp4 Promotes Autoimmune Diabetes Through Activation On Macrophages And Tissue Resident Memory T Lymphocytes, Shs Young Investigator Symposium & Gwanak Symposium. 2019.
Sun W.Y., Bai B., Luo C., Yang K., LI D., Wu D., Feletou M., Villeneuve N., Zhou Y., Yang J., Xu A., Vanhoutte P.M.G.R. and Wang Y., Lipocalin-2 derived from adipose tissue mediates aldosterone-induced renal injury, Journal of Clinical Investigation Insight. 2018, 3(17): e120196.
WANG X., Liu Y., Xu A. and Leung W.K., Alveolar and tibial bone status in obese mice with exercise, Journal of Dental Research. 2018, 97 (Spec Iss B): 3510.
Wang B., Lin H., Li X., Lam K.S.L., Xu A. and Cheng K., APPL2 deficiency suppresses glucose-stimulated insulin secretion by disrupting F-actin remodeling in pancreatic β cells, 2018 Asia Islet Biology & Incretin Symposium. 2018.
Wong Y.K., Cheung Y.Y., Tang S.M., Au K.W., Hai S.H.J.J., Lee C.H.P., Lau G.K.K., Cheung B.M.Y., Sham P.C., Xu A., Lam K.S.L. and Tse H.F., Age-Biomarkers-Clinical Risk Factors for Prediction of Cardiovascular Events in Patients With Coronary Artery Disease., Arterioscler Thromb Vasc Biol. American Heart Association, Inc., 2018, 38: 2519-2527.
Xiao Y., Xiao X., Xu A., Chen X., Tang W. and Zhou Z., Circulating adipocyte fatty acid-binding protein levels predict the development of subclinical atherosclerosis in type 2 diabetes, Journal of Diabetes and its Complications. 2018, 32: 1100-1104.
Yang J., Lu J., Yuan S.-.S., Cao X., Qiu H., Shi T., Yang F., Li Q., Liu C., Wu Q., Wang Y., Huang H., Kayoumu A., Feng J., Xie R., Zhu X., Liu C., Yang G., Xie C., Chen C., Chen C., zhang B., liu G., zhang X. and Xu A., From Hyper- to Hypoinsulinemia and Diabetes: Effect of KCNH6 on Insulin Secretion, Cell Reports. 2018, 25: 3800-3810.e6.
Yau S.Y., Lee T.H.Y., Li A., Xu A. and So K.F., Adiponectin Mediates Running-Restored Hippocampal Neurogenesis in Streptozotocin-Induced Type 1 Diabetes in Mice, Frontiers in Neuroscience. 2018, 12.


Researcher : Xu P

List of Research Outputs

Xu P., Hui K.M.C., Lui M.S.M., Lam C.L.D., Fong D.Y.T. and Ip M.S.M., Incident Type 2 Diabetes in OSA and Effect of CPAP Treatment, Chest. 2019.


Researcher : YAO Q

List of Research Outputs

Wong K.Y., YAO Q., Yuan L., LI Z., Ma E.S.K. and Chim J.C.S., Frequent functional activation of RAS signalling not explained by RAS/RAF mutations in relapsed/refractory multiple myeloma, Scientific Reports. 2018, 8.
YAO Q., Morgan G.J. and Chim J.C.S., Distinct promoter methylation profile reveals spatial epigenetic heterogeneity in 2 myeloma patients with multifocal extramedullary relapses, Clinical Epigenetics. 2018, 10.
YAO Q., BAI Y., Orfao A. and Chim J.C.S., Standardized Minimal Residual Disease Detection by Next-Generation Sequencing in Multiple Myeloma, Frontiers in Oncology. 2019, 9.


Researcher : YU J

List of Research Outputs

YU J., Yung S.S.Y., Chan C.Y.C., Chau K.M. and Chan D.T.M., Gut-derived lipopolysaccharide contributes to pathogenesis of lupus nephritis, ISN World Congress of Nephrology 2019.


Researcher : YU Y

List of Research Outputs

CHEN Y., Liu Y., Seto W.K.W., Wu M., YU Y., Lam Y.M., Au W.K., Chan D., Sit K.Y., Ho L.M., Tse H.F. and Yiu K.H., Prognostic Value of Hepatorenal Function By Modified Model for End‐stage Liver Disease (MELD) Score in Patients Undergoing Tricuspid Annuloplasty, Journal of the American Heart Association. 2018, 7: e009020.
Chan Y.H., Ngai M.C., Chen Y., Wu M., YU Y., ZHEN Z., Lai K.W.H., Cheung T.T., Ho L.M., Chung H.Y., Lau W.C.S., Tse H.F. and Yiu K.H., Cumulative Rheumatic Inflammation Modulates the Bone–Vascular Axis and Risk of Coronary Calcification, Journal of the American Heart Association. 2019, 8.
Chan Y.H., Ngai M.C., Chen Y., Wu M., YU Y., ZHEN Z., Lai K.W.H., Cheung T.T., Ho L.M., Chung H.Y., Lau W.C.S., Lau C.P., Tse H.F. and Yiu K.H., Osteogenic circulating endothelial progenitor cells are linked to electrocardiographic conduction abnormalities in rheumatic patients, Annals of Noninvasive Electrocardiology. 2019, e12651.
Chen Y., Liu Y., Seto W.K.W., Wu M., YU Y., Lam Y.M., Au T.W.K., Sit K.Y., Ho L.M., Tse H.F. and Yiu K.H., Prognostic Value of Hepatorenal Function By Modified Model for End-stage Liver Disease (MELD) Score in Patients Undergoing Tricuspid Annuloplasty, Journal of the American Heart Association. 2018, 7(14): 1-11.


Researcher : Yan S

Project Title:19th World Conference on Lung Cancer; The Role of Contactin 1 on Acquired Resistance to Pegylated Arginase in Small Cell Lung Cancer
Investigator(s):Yan S
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:09/2018
Completion Date:09/2018


List of Research Outputs

Lam S.K., Yan S., XU S., U K.P., Cheng P.N. and Ho J.C.M., Endogenous arginase 2 as a potential biomarker for PEGylated arginase 1 treatment in xenograft models of squamous cell lung carcinoma , Oncogenesis. 2019, 8: 18.
Lam S.K., Yan S., XU S. and Ho J.C.M., Targeting polyamines as potential adjuvant therapy in malignant pleural mesothelioma xenograft models, IASLC 19th World Conference on Lung Cancer. 2018.
Lam S.K., Yan S., XU S. and Ho J.C.M., Targeting polyamines as potential adjuvant therapy in malignant pleural mesothelioma xenograft models, 24th Medical Research Conference. Medical Journal, 2019, 25: 26.


Researcher : Yang N

Project Title:Identifying biomarkers predictive of treatment response to PEGylated recombinant human arginase I in AML and its therapeutic partners
Investigator(s):Yang N, Leung AYH
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:06/2019




Researcher : Yap YHD

Project Title:Relationship between Mycophenolic Acid Pharmacokinetics and Pharmacogenomics with treatment response and disease activity in lupus nephritis
Investigator(s):Yap YHD, Ma KMM, Chan DTM, Yung SSY
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:04/2015


Project Title:Lymphocyte subset profile and clinical phenotype in lupus nephritis
Investigator(s):Yap YHD, Chan DTM, Yung SSY
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:04/2016


Project Title:An Anti-Phospholipase A2 Receptor Antibody Monitoring Program for Patients with Idiopathic Membranous Nephropathy
Investigator(s):Yap YHD, Chan DTM
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:03/2018


Project Title:Investigating the B cell signatures for disease flare and response to pre-emptive immunosuppressive therapy in patients with lupus nephritis
Investigator(s):Yap YHD, Yung SSY, Chan DTM
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:04/2018


List of Research Outputs

CHEN Y., Au T.W.K., Chan D., Sit K.Y., Zhen Z., Ho K.L., Wong D., Ho L.M., Yap Y.H.D., Lam Y.M., Lau C.P., Tse H.F., Chan D.T.M. and Yiu K.H., Clinical Benefit of Valvular Surgery in Patients with Chronic Kidney Disease, International Heart Journal. 2018, 59: 759-765.
Chen Y., Au T.W.K., Chan D., Sit K.Y., Zhen Z., Ho K.L., Wong D., Ho L.M., Yap Y.H.D., Lam Y.M., Lau C.P., Tse H.F., Chan D.T.M. and Yiu K.H., Clinical Benefit of Valvular Surgery in Patients with Chronic Kidney Disease. , International heart journal. 2018, 59(4): 759-765.
Li C., Yap Y.H.D., Chan S.W.G., Wen Y., Li H., Tang S.O.C., Li X., Li X. and Chan D.T.M., Clinical Outcomes and Clinico-pathological Correlations in Lupus Nephritis with Kidney Biopsy Showing Thrombotic Microangiopathy, The Journal of Rheumatology. 2019, jrheum.180773.
Lui D.T.W., Lee A.C.H., Yap Y.H.D., Chan G.S.W. and Tan K.C.B., A young Chinese man with nephrotic syndrome due to lipoprotein glomerulopathy, Journal of Clinical Lipidology. 2018, 13: 251-253.
Lui S.L., Yap Y.H.D., Cheng C.C.V., Chan D.T.M. and Yuen K.Y., Clinical practice guidelines for the provision of renal service in Hong Kong: Infection Control in Renal Service, Nephrology. 2019, 24 Suppl 1: 98-129.
Mok M.Y.M., Liu C.K., Lam M.F., Chan G.C., Ma K.M.M., Yap Y.H.D., Chiu F., Choy C.B., Tang S.C. and Chan D.T.M., A LONGITUDINAL STUDY ON THE PREVALENCE AND RISK FACTORS FOR DEPRESSION AND ANXIETY, QUALITY OF LIFE, AND CLINICAL OUTCOMES IN INCIDENT PERITONEAL DIALYSIS PATIENTS, Perit Dial Int.. 2018.
Yap Y.H.D., Challenges and advances in the prevention and management of chronic kidney diseases, NCD Forum 2019, Hong Kong. 2019.
Yap Y.H.D., Tang S.O.C., Chan G.C.W., Kwan P.Y.L., Ma K.M.M., Mok M.Y. and Chan D.T.M., Longterm Data on Sirolimus Treatment in Patients with Lupus Nephritis, The Journal of Rheumatology. 2018, 45(12): 1663-1670.
Yap Y.H.D., Yung S.S.Y. and Chan D.T.M., Lupus nephritis: An update on treatments and pathogenesis, Nephrology. 2018, 23 (Suppl 4): 80-83.
Yap Y.H.D., Tam C.H., Yung S.S.Y., Wong S., Tang S.O.C., Mok M.Y.T., Yuen C.K.Y., Ma M.K.M., Lau W.C.S. and Chan D.T.M., Pharmacokinetics and pharmacogenomics of mycophenolic acid and its clinical correlations in maintenance immunosuppression for lupus nephritis, Nephrol Dial Transplant. 2018.
Yap Y.H.D., Tam C.H., Yung S.S.Y., Wong S., Tang S.O.C., Mok M.Y.T., Yuen K.Y.C., Ma K.M.M., Lau W.C.S. and Chan D.T.M., Pharmacokinetics and pharmacogenomics of mycophenolic acid and its clinical correlations in maintenance immunosuppression for lupus nephritis, Nephrology Dialysis Transplantation. 2018.
Yung S.S.Y., Yap Y.H.D. and Chan D.T.M., Chapter 5 “狼疮性肾炎的转化研究及新进展”, in, 腎脏疾病的转化医学研究和临床实践, 转化医学出版工程,“十三五” 倪兆慧, Claudio Ronco, 牟姗, Simon Davies, Tak Mao Chan, Editors. 国家重点图书出版规划项目, 上海科技专著出版资金资助项目, 2019.


Researcher : Yau TCC

Project Title:The Role of Serial Changes in Circulating Angiogenic Markers in Predicting the Clinical Outcome of Advanced Hepatocellular Carcinoma (HCC) Patients on Sorafenib
Investigator(s):Yau TCC, Fan ST, Poon RTP, Pang RWC
Department:Surgery
Source(s) of Funding:Seed Fund for Basic Research
Start Date:06/2011


Project Title:4th Biennial Congress of the Asian-Pacific Hepato-Pancreato-Biliary Association; Systemic treatment of metastatic neuroendocrine tumors to the liver/Local-regional therapy for colorectal liver metastases
Investigator(s):Yau TCC
Department:Surgery
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:03/2013


Project Title:The Role of Insulin Growth Factor (IGF) Level in Cachexia and Treatment Outcome in Advanced Pancreatic Cancer Patients
Investigator(s):Yau TCC, Poon RTP
Department:Surgery
Source(s) of Funding:Small Project Funding
Start Date:06/2013


Project Title:A Phase II study of the safety and efficacy of PEG-BCT-100 combined with capecitabine/oxaliplatin in patients with advanced hepatocellular carcinoma (Part I)
Investigator(s):Yau TCC
Department:Medicine
Source(s) of Funding:Matching Grant for Joint Research
Start Date:04/2014


Project Title:A Prospective Validation of the Hong Kong Liver Cancer (HKLC) Prognostic Staging System: A Multi-Centre Study in Hong Kong
Investigator(s):Yau TCC, Cheung TT
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2016


Project Title:A Combination of Sorafenib, Oxaliplatin and Capecitabine as Neoadjuvant Therapy for Patients with Locally Advanced Hepatocelullar Carcinoma: A Phase II Study
Investigator(s):Yau TCC, Cheung TT
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:12/2016
Completion Date:01/2020


Project Title:A Phase 1b Study of Polo-like Kinase 4 inhibitor CFI-400945 in Advanced Hepatocellular Carcinoma
Investigator(s):Yau TCC, Wong CCL, Chiu WYJ
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2018


List of Research Outputs

Chiu W.Y.J., Leung R.C.Y., Tang Y.F.V., Cheuk W.Y.I., Lo L.F., Kwok G.W., Wong H.Y.H., Suen T.K.D., Cheung P., Wong T.T., Yau T.C.C. and Kwong A., Changing pattern of recurrences in patients with early HER2-positive breast cancer receiving neoadjuvant chemotherapy in the era of dual anti-HER2 therapy, Postgraduate Medical Journal. 2019, 95: 155-161.
El Dika I., Lim H.Y., Yong W.P., Lin C.C., Yoon J.H., Modiano M., Freilich B., Choi H.J., Chao T.Y., Kelley R.K., Brown J., Knox J., Ryoo B.Y., Yau T.C.C. and Abou-Alfa G.K., An Open-Label, Multicenter, Phase I, Dose Escalation Study with Phase II Expansion Cohort to Determine the Safety, Pharmacokinetics, and Preliminary Antitumor Activity of Intravenous TKM-080301 in Subjects with Advanced Hepatocellular Carcinoma, Oncologist. 2019, 24: 747-e218.
Wong K.P., Lang H.H.B., Lam K.O., Shek T.W.H. and Yau T.C.C., Poster presentation: PD-L1 expression in patients with anaplastic thyroid carcinoma: prevalence and outcome, The 88th Annual Meeting of the American Thyroid Association (ATA), Washington, U.S.A., 3-7 October 2018. 2018.
Yau T.C.C., Checkpoint Inhibitors and Tyrosine Inhibitors Post Immunotherapy in the Management of Advanced HCC, Ipsen HCC Asia Scientific Meeting, Seoul, South Korea. 2019.
Yau T.C.C., Development of Immunotherapy in Hepatocellular Carcinoma Patients, 4th International Hepatobiliary & Pancreatic Diseases Summit Forum, Hangzhou, China. 2018.
Yau T.C.C., Development of Immunotherapy in Hepatocellular Carcinoma Patients, Bristol-Myers Squibb Satellite Symposium in HCC, Macau. 2019.
Yau T.C.C., Early Clinical Trials in Hong Kong (Oncology)-Opportunities & Challenges, Phase 1 Centre, West Hospital, Chengdu, China. 2019.
Yau T.C.C., Immune Checkpoint Inhibitor for Hepatocellular Carcinoma, Multi-specialty Medical Mega Conference, Hong Kong. 2019.
Yau T.C.C., Immune-related Adverse Event Management Algorithms, AstraZeneca EMERALD-1 Investigators’ Meeting, New Orleans, USA. 2019.
Yau T.C.C., Immunotherapy in Advanced Hepatocellular Carcinoma, MSD HCC Regional Expert Input Forum, Shanghai, China. 2019.
Yau T.C.C., Immunotherapy in Hepatocellular and Pancreatic Cancer: Hong Kong Experiences, First Oncology Forum, Shulan Hospital, Hangzhou, China. 2018.
Yau T.C.C., Neuroendocrine Tumor Treatment Development in Asia, The 2st Asian NET Expert Meeting, Taipei, Taiwan. 2019.
Yau T.C.C., Portending the future: How will a positive 1st line trial with check-point inhibitors in HCC change the treatment paradigm in HCC, 6th Asia Pacific Gastroenterology Cancer Summit 2019, Singapore. 2019.
Yau T.C.C., Real-world Experience with Cabozantinib, Ipsen HCC Asia Scientific Meeting, Seoul, South Korea. 2019.
Yau T.C.C., Taking a Leap Forward in Advanced Hepatocellular Carcinoma, Research Meeting, CStone Pharmaceuticals, Shanghai, China. 2019.
Yau T.C.C., Taking a Leap Forward: What is the Latest Evidence of Systemic Therapy in Advanced Hepatocellular Carcinoma?, 26th Annual Scientific Meeting of Hong Kong College of Radiologists, Hong Kong. 2018.
Yau T.C.C., The Use of Cabozantinib in Advanced HCC: CELESTIAL Experiences, Ipsen Expert Panel Meeting in Hepatocellular Carcinoma, Hong Kong. 2019.
Yau T.C.C., Treating Hepatocellular Carcinoma: A Fight Against the Odds, Bristol-Myers Squibb Satellite Symposium in HCC, Bangkok, Thailand. 2019.
Yau T.C.C., Updates on Immunotherapy in HCC, 3rd Singapore Liver Cancer Consortium (SLCC) Symposium Programme, Singapore. 2019.
Yau T.C.C., What Are The Latest Advances in Hepatobiliary and Pancreatic Cancers in 2018?, Hepatobiliary Meeting, Hong Kong Sanatorium & Hospital, Hong Kong. 2018.
Yau T.C.C., What is the role for cabozantinib as a new option in second-line aHCC?, 1st Ipsen Asia-Pacific Advisory Board in Hepatocellular Carcinoma, Seoul, Korea. 2018.


Researcher : Ye D

Project Title:Gut Microbiota Modulation of Host Physiology: The Search for Mechanism (C1); Neutrophil-derived Lipocalin-2 Mediates Nonalcoholic Steatohepatitis through Modulating Crosstalk between Mucosa Immunity and Gut Microbiota
Investigator(s):Ye D
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:03/2015




Researcher : Yeung CK

Project Title:HLA-B* 58:01 allele screening to reduce allopurinol-induced severe cutaneous reactions in patients with chronic kidney disease in Hong Kong
Investigator(s):Yeung CK, Tang SCW, Cheung BMY
Department:Medicine
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:01/2012


List of Research Outputs

Chan W.M.M., Shek Y.N.S., Yeung C.K. and Chan H.L.H., A prospective study in the treatment of lentigines in Asian skin using 532 nm picosecond Nd: YAG laser. , In: Brian Wong, Lasers in Surgery and Medicine. Lasers in Surgery and Medicine, 2019.


Researcher : Yeung CY

List of Research Outputs

Chan M.L., Cheung C.L., Lee C.H.A., Yeung C.Y., Siu D.C.W., Leung J.Y., Pang H.K. and Tan K.C.B., Genetic variations in familial hypercholesterolemia and cascade screening in East Asians, Mol Genet Genomic Med. 2019, 7(2): e00520.


Researcher : Yeung PNP

List of Research Outputs

Friedrich S., Yeung P.N.P., Platzbecker K., Burns S.M., Banner-Goodspeed V., Weimar C., Sabramaniam B., Houle T.T., Bhatt D.L. and Eikermann M., Patent foramen ovale and long-term risk of ischaemic stroke after surgery, European Heart Journal. 2019, 40: 914-924.
Rudolph M.I., Yeung P.N.P., Deng H., Scheffenbichler F.T., Grabitz S.D., Wanderer J.P., Houle T.T. and Eikermann M., Comparison of a novel clinical score to estimate the risk of REsidual neuromuscular block Prediction Score and the last train-of-four count documented in the electronic anaesthesia record, European Journal of Anaesthesiology. 2018, 35: 1.
Rudolph M.I., Chitilian H.V., Yeung P.N.P., Timm F.P., Agarwala A.V., Doney A.B., Ramachandran S.K., Houle T.T. and Eikermann M., Implementation of a new strategy to improve the peri-operative management of neuromuscular blockade and its effects on postoperative pulmonary complications, Anaesthesia. 2018, 73: 1067-1078.
Sin W.C., Yeung P.N.P., Ngai C.W., Lai C.K.P., Chan W.K.R. and Mok Y.T.A., Education Curriculum on Extracoporeal Membrane Oxygenation – the Evolving Role of Simulation Training. , Advances in Extra-corporeal Perfusion Therapies. IntechOpen, 2019.
Sin W.C., Yeung P.N.P., Ngai W.C.W., Lai P.C.K., Mok A.Y.T. and Chan R.W.K., Simulation training for crises during venoarterial extracorporeal membrane oxygenation, Journal of Thoracic Disease. 2019, 11: 2144-2152.
Tsai N.W.P., Leung Y.M., Yeung P.N.P., Liong T.I.N.G., Lee S.F., Ngai C.W., Sin W.C., Koo J. and Chan W.M., Attitudes of visitors at adult intensive care unit toward organ donation and organ support, Chinese Medical Journal. 2019, 132: 373-376.
Yeung P.N.P., ECMO Emergencies and Complications, APELSO Adult ECMO Training Course. 2018.


Researcher : Yeung SC

List of Research Outputs

CHEN R., Yeung S.C., Ip M.S.M. and Mak J.C.W., The Role of ORMDL3 in Cigarette Smoke-induced Airway Injury, American Thoracic Society (ATS) and International Society of Respiratory Diseases (ISRD). 2019, 199: A3759.
CHEN R., Yeung S.C., Ip M.S.M. and Mak J.C.W., The role of ORMDL3 in cigarette smoke-induced airway injury, American Thoracic Society (ATS) International Conference 2019. 199: A3759.
Han Q., Yeung S.C., Ip M.S.M. and Mak J.C.W., Dysregulation of cardiac lipid parameters in high-fat high-cholesterol diet-induced rat model, Lipids Health Dis. 2018, 17: 255.
Wong S.M., Lam W., Ge M., Yeung S.C., Liang Y., Ip M.S.M. and Mak J.C.W., Cardiac and Pulmonary Inflammatory Responses by Intermittent Hypoxia in C57BL/6N and C57BL/6J Mouse Strains, 24th Medical Research Conference, Department of Medicine, HKU, Hong Kong Medical Journal. 2019, 25: 32.
Yeung S.C., Ge M., Mak J.C.W. and Ip M.S.M., Differential effects of intermittent hypoxia on systemic and adipose tissue inflammation in lean and diet-induced obese mice, 24th Medical Research Conference, Department of Medicine, HKU, January 2019. Hong Kong Medical Journal. 2019, 25 (Suppl 1): 45.


Researcher : Yick LW

Project Title:Defining the roles of epidermal growth factor (EGF) in the regulation of chondrocyte differentiation and endochondral bone formation
Investigator(s):Yick LW, Chan SY
Department:Paediatrics & Adolescent Med
Source(s) of Funding:Small Project Funding
Start Date:11/2004


List of Research Outputs

Chan K.H. and Yick L.W., Memantine and pioglitazone ameliorate motor impairments and complement-independent cord pathologies in mice received aquaporin-4 autoantibodies from neuromyelitis optica spectrum disorder (NMOSD) patients, 11th Congress of the Pan-Asian Committee for Treatment and Research in Multiple Sclerosis 2018, Sydney. 2018.
Ma K.F.O., Ng C.L., Yick L.W., Jian M. and Chan K.H., In vivo electroporation-mediated transfer of interleukin-35 gene decreases demyelination in animal model of multiple sclerosis, 24th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2019, ;25(1)(Supplement 1): 32.
Yick L.W. and Chan K.H., Memantine and pioglitazone ameliorate motor impairments and spinal cord pathologies in mice received aquaporin-4 autoantibodies from patients with neuromyelitis optica spectrum disorders, 24th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2019, 25(1)(Supplement 1).


Researcher : Yim RLH

List of Research Outputs

Singh G.H.H., Ip H.W., Yim R.L.H., Tang W.F., Pang H.M.H., Lee P., Leung G.M.K., Li J.W.Y., Tang K., So J.C.C., Leung R.Y.Y., Li J., Panagiotou I., Lam C.C.K. and Kwong Y.L., Next-generation sequencing with a 54-gene panel identified unique mutational profile and prognostic markers in Chinese patients with myelofibrosis, Annals of Hematology. 2018.
Singh G.H.H., Kumana C.R., Yim R.L.H., Hwang Y.Y.G., Chan S.Y.T., Yip S.F., Lee H.K.K., Mak V., Lau J.S.M., Chan C.C., Kho B., Wong R.S.M., Li W., Lin S.Y., Lau C.K., Ip H.W., Leung R.Y.Y., Lam C.C.K. and Kwong Y.L., Oral arsenic trioxide incorporation into frontline treatment with all‐trans retinoic acid and chemotherapy in newly diagnosed acute promyelocytic leukemia: A 5‐year prospective study, Cancer. 2019.


Researcher : Yiu KH

Project Title:Role of Angiotensin Receptor Blocker to Decrease the Progression of Left Ventricular Remodeling in Patients with Asymptomatic Aortic Stenosis
Investigator(s):Yiu KH, Tse HF
Department:Medicine
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2016


Project Title:Reversibility of liver stiffness after tricuspid annulopasty: A case-control study
Investigator(s):Yiu KH, Tse HF, Seto WKW
Department:Medicine
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:07/2016
Completion Date:12/2019


Project Title:Development Of A Novel Cardiac Imaging Technique To Detect Silent Brain Infarction In The Elderly To Prevent Subsequent Vascular Dementia
Investigator(s):Yiu KH, Lee W, Mak HKF
Department:Medicine
Source(s) of Funding:Midstream Research Programme for Universities (MRP)
Start Date:01/2018


Project Title:Development Of A Novel Cardiac Imaging Technique To Detect Silent Brain Infarction In The Elderly To Prevent Subsequent Vascular Dementia
Investigator(s):Yiu KH, Lee W, Mak HKF
Department:Medicine
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:09/2018


Project Title:Development Of A Novel Cardiac Imaging Technique To Detect Silent Brain Infarction In The Elderly To Prevent Subsequent Vascular Dementia
Investigator(s):Yiu KH, Lee W, Mak HKF
Department:Medicine
Source(s) of Funding:Postdoctoral Hub Programme for ITF projects
Start Date:10/2018


List of Research Outputs

CHEN Y., Au T.W.K., Chan D., Sit K.Y., Zhen Z., Ho K.L., Wong D., Ho L.M., Yap Y.H.D., Lam Y.M., Lau C.P., Tse H.F., Chan D.T.M. and Yiu K.H., Clinical Benefit of Valvular Surgery in Patients with Chronic Kidney Disease, International Heart Journal. 2018, 59: 759-765.
CHEN Y., Liu Y., Seto W.K.W., Wu M., YU Y., Lam Y.M., Au W.K., Chan D., Sit K.Y., Ho L.M., Tse H.F. and Yiu K.H., Prognostic Value of Hepatorenal Function By Modified Model for End‐stage Liver Disease (MELD) Score in Patients Undergoing Tricuspid Annuloplasty, Journal of the American Heart Association. 2018, 7: e009020.
Chan Y.H., Ngai M.C., Chen Y., Wu M., YU Y., ZHEN Z., Lai K.W.H., Cheung T.T., Ho L.M., Chung H.Y., Lau W.C.S., Tse H.F. and Yiu K.H., Cumulative Rheumatic Inflammation Modulates the Bone–Vascular Axis and Risk of Coronary Calcification, Journal of the American Heart Association. 2019, 8.
Chan Y.H., Ngai M.C., Chen Y., Wu M., YU Y., ZHEN Z., Lai K.W.H., Cheung T.T., Ho L.M., Chung H.Y., Lau W.C.S., Lau C.P., Tse H.F. and Yiu K.H., Osteogenic circulating endothelial progenitor cells are linked to electrocardiographic conduction abnormalities in rheumatic patients, Annals of Noninvasive Electrocardiology. 2019, e12651.
Chen Y., Au T.W.K., Chan D., Sit K.Y., Zhen Z., Ho K.L., Wong D., Ho L.M., Yap Y.H.D., Lam Y.M., Lau C.P., Tse H.F., Chan D.T.M. and Yiu K.H., Clinical Benefit of Valvular Surgery in Patients with Chronic Kidney Disease. , International heart journal. 2018, 59(4): 759-765.
Chen Y., Liu Y., Seto W.K.W., Wu M., YU Y., Lam Y.M., Au T.W.K., Sit K.Y., Ho L.M., Tse H.F. and Yiu K.H., Prognostic Value of Hepatorenal Function By Modified Model for End-stage Liver Disease (MELD) Score in Patients Undergoing Tricuspid Annuloplasty, Journal of the American Heart Association. 2018, 7(14): 1-11.
Chen Y., Liu Y., Wu M., Lam Y.M., Ho L.M., Lau C.P., Au T.W.K., Tse H.F. and Yiu K.H., Prognostic value of tricuspid valve geometry and leaflet coaptation status in patients undergoing tricuspid annuloplasty: a three-dimensional echocardiography study, PCR Tokyo Valves 2019.
Huang D., Cheng Y., Wong Y.T.A., Yung S.A., Tam C.C., Chan K.W.K., Lam C.C.S., Yiu K.H., Hai S.H.J.J., Lau C.P., Chan E.W.Y., Chiang C.E., Wong K.L., Cheung T.T., Cheung B.M.Y., Feng Y.Q., Tam N., Chen J.Y., Yue W.S., Hu H.X., Chen L., Tse H.F., Chan P.H.M. and Siu D.C.W., Thrombolysis in myocardial infarction risk score for secondary prevention of recurrent cardiovascular events in a real-world cohort of post-acute myocardial infarction patients, Circulation. 2019, 83(4): 809-817.
Liu F.Z., Lin W.D., Liao H.T., Peng J., Xue Y.M., Zhan X.Z., Zhu J.M., Yiu K.H., Li Y.F., Tse H.F., Shi L., Fang X.H. and Wu S.L., Mid-term outcomes of concomitant left atrial appendage closure and catheter ablation for non-valvular atrial fibrillation: a multicenter registry., Heart Vessels. 2019, 34(5): 860-867.
WANG Y., Liu H.N., Zhen Z., Yiu K.H., Tse H.F., Zhang C., Pelekos G. and Jin L., Periodontal treatment increases circulating EPC counts in patients with T2DM, Journal of Dental Research. 2018, 97 (Spec Iss B): 1114.
WANG Y., Zhen Z., Liu H.N., Lai I.A., Pelekos G., Tse H.F., Yiu K.H. and Jin L., Periodontitis links to exacerbation of myocardial dysfunction in subjects with type 2 diabetes, Journal of Periodontal Research. 2019, 54: 339-348.
Wu M., Chen Y., Au T.W.K., Chan D., Sit K.Y., Ho K.L., Ho L.M., Lam Y.M., Lau C.P., Chan D.T.M., Tse H.F. and Yiu K.H., Predictive value of acute kidney injury for major adverse cardiovascular events following tricuspid annuloplasty: A comparison of three consensus criteria, Journal of Cardiology. 2018, 72: 247-254.
ZHAO D., Yiu K.H., Wu M., Yu S.Y., Pelekos G. and Jin L., Is severe periodontitis a pre-indicator of abnormal systemic conditions?, Journal of Dental Research. 2019, 98 (Spec Iss A): 0361.
ZHAO D., Zhen Z., Pelekos G., Yiu K.H. and Jin L., Periodontal disease increases the risk for onset of systemic comorbidities in dental hospital attendees: An 18-year retrospective cohort study, Journal of Periodontology. 2019, 90: 225-233.


Researcher : Yiu WH

Project Title:ASN Kidney Week 2013 Annual Meeting ; Tissue Kallikrein Mediates Pro-inflammatory Pathways in Proximal Tubular Epithelial Cells
Investigator(s):Yiu WH
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:11/2013


Project Title:ASN Kidney Week 2018; The long noncoding RNA Meg3 mediates TLR4–induced renal inflammation in experimental obstructive nephropathy
Investigator(s):Yiu WH
Department:Medicine
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2018
Completion Date:10/2018


List of Research Outputs

Chan K.W., Kwong A.S.K., Chan G.C.W., Leung C.P.S., Yiu W.H., Lui S.L., Ip T.P., Cowling B.J., Wong W.L.D., LI B., LI Y., Feng Y., Chan L.Y.Y., Leung J.C.K., Tan K.C.B., Wong C.W.V., Lai K.N. and Tang S.C.W., Best Poster Award, Good Practice In Traditional Chinese Medicine Research Association. 2018.
Chan K.W., Kwong A.S.K., Chan G.C.W., Leung C.P.S., Yiu W.H., Lui S.L., Ip T.P., Cowling B.J., Wong W.L.D., LI B., LI Y., Feng Y., Chan Y.Y., Leung J.C.K., Tan K.C.B., Wong C.W.V., Lai K.N. and Tang S.C.W., Semi-individualised Chinese Medicine Treatment for Diabetic Kidney Disease – From users’ perspectives to SCHEMATIC trial interim result and potential mechanisms, Advances in Integrative Medicine (International Congress on Complementary Medicine Research). 2019, 6: S12.
LI B., Leung J.C.K., Chan Y.Y., Yiu W.H., LI Y., LOK W.Y., Liu W.H., Chan K.W., Tse H.F., Lai K.N. and Lai K.N., Amelioration of Endoplasmic Reticulum Stress by Mesenchymal Stem Cells Via Hepatocyte Growth Factor/c‐Met Signaling in Obesity‐Associated Kidney Injury, STEM CELLS Translational Medicine. 2019.
LI B., Leung J.C.K., Chan L.Y., Yiu W.H., Lai K.N. and Tang S.C.W., Mesenchymal Stem Cells Derived from Induced Pluripotent Stem Cells and Bone Marrow Are Equally Effective in Ameliorating Lipotoxicity-Induced Kidney Injury (Conference Abstract)., J Am Soc Nephrol. 2018, 29: 284.
Yiu W.H., Role of Renal Tubular Wnt/Beta-catenin in Proteinuric Kidney, Hong Kong Society of Nephrology Annual Scientific Meeting 2018. 2018.
Yiu W.H., Wong D.W., LOK W.Y., Liu W.H., LI Y., CHAN L.Y., Leung J.C.K., Lan H.Y. and Tang S.C.W., The Long Noncoding RNA Meg3 Mediates TLR4–Induced Renal Inflammation in Experimental Obstructive Nephropathy (Conference Abstracts) , J Am Soc Nephrol . 2018, 29: 953.


Researcher : Yu SY

List of Research Outputs

ZHAO D., Yiu K.H., Wu M., Yu S.Y., Pelekos G. and Jin L., Is severe periodontitis a pre-indicator of abnormal systemic conditions?, Journal of Dental Research. 2019, 98 (Spec Iss A): 0361.


Researcher : Yuen JCH

List of Research Outputs

Yuen R.M.F., Liu S.H.K., Seto W.K.W., Wong D.K.H., Wong S.Y., Cheung K.S.M., Mak L.Y.L., Ko K.L.M., To W.P.E., Yuen J.C.H., Wu C.H., Cheng C.T.K., Wu J.T.K. and Lau E.H.Y., Faculty Knowledge Exchange Award, HKU LKS Faculty of Medicine. 2019.


Researcher : Yuen JKY

List of Research Outputs

Yuen J.K.Y., Effective Strategies for Teaching 21st Century Skills (Keynote Address), Teaching and Learning Innovation Expo 2018, The Chinese University of Hong Kong. 2018.
Yuen J.K.Y., See C.Y.H., Lum C.M., Cheung T.K. and Wong W.T., Empathy Training for Medical Students through a Blended Learning Communication Skills Training Program: a Mixed-Methods Study, Asia Pacific Medical Education Conference, National University of Singapore, Singapore. 2019.
Yuen J.K.Y. and Carson R., Serious Illness Care: More, Better, Earlier Conversations., Hospital Authority Central Commissioned Training Program: The Emerging Roles of Renal Palliative Care. 2019.


Researcher : Yuen KYC

List of Research Outputs

Yap Y.H.D., Tam C.H., Yung S.S.Y., Wong S., Tang S.O.C., Mok M.Y.T., Yuen K.Y.C., Ma K.M.M., Lau W.C.S. and Chan D.T.M., Pharmacokinetics and pharmacogenomics of mycophenolic acid and its clinical correlations in maintenance immunosuppression for lupus nephritis, Nephrology Dialysis Transplantation. 2018.


Researcher : Yuen MAM

List of Research Outputs

Cheung Y.Y., Lee C.H.P., Tang S.M., Xu A., Au K.W., Fong H.Y., Ng K.K., KWOK H.M., Chow W.S., Woo Y.C., Yuen M.A.M., Hai S.H.J.J., Tan K.C.B., Lam T.H., Tse H.F., Sham P.C. and Lam K.S.L., Genetic regulation of Pigment Epithelium-Derived Factor (PEDF): an exome-chip association analysis in Chinese subjects with type 2 diabetes, Diabetes. 2019, 68: 198-206.
Lee C.H.P., Cheung Y.Y., Woo Y.C., Lui D.T.W., Yuen M.A.M., Fong H.Y., Chow W.S., Xu A. and Lam K.S.L., Circulating Adipocyte Fatty Acid–Binding Protein Concentrations Predict Multiple Mortality Outcomes among Men and Women with Diabetes, Clinical Chemistry. 2018, clinchem.2018.289157.
Lee C.H.P., Cheung Y.Y., Woo Y.C., Lui D.T.W., Yuen M.A.M., Fong H.Y., Chow W.S., Xu A. and Lam K.S.L., Prospective associations of circulating adipocyte fatty acid-binding protein levels with risks of renal outcomes and mortality in type 2 diabetes, Diabetologia. 2019, 62: 169-177.


Researcher : Yuen MF

Project Title:An open label study of adefovir dipivoxil for the treatment of patients with chronic hepatitis B (CHB) related advanced fibrosis or cirrhosis
Investigator(s):Yuen RMF
Department:Medicine
Source(s) of Funding:Glaxo Wellcome Hong Kong Ltd. - General Award
Start Date:07/2005


Project Title:Randomized, open-label, comparative study to evaluate early viral load reductions and exploratory viral kinetics following administration of entecavir or adefovir in nucleoside-naïve adults with chronic hepatitis B infection
Investigator(s):Yuen RMF
Department:Medicine
Source(s) of Funding:Bristol-Myers-Squibb (HK) - General Award
Start Date:01/2006


Project Title:A phase I, multi-centre, randomised, placebo-controlled, dose escalation study to assess the local and systemic tolerability of the therapeutic DNA plasmid pdpSC18 vaccine administered by particle mediated epidermal delivery using the powderject ND 10 delivery system in subjects with chronic hepatitis B infection
Investigator(s):Yuen RMF
Department:Medicine
Source(s) of Funding:PowderMed Ltd - General Award
Start Date:11/2006


Project Title:Significance of HBV DNA in the natural history of chronic hepatitis B: impact on disease outcome including significant fibrosis and hepatocellular carcinoma
Investigator(s):Yuen RMF
Department:Medicine
Source(s) of Funding:Bristol-Myers-Squibb (HK) - General Award
Start Date:09/2007


Project Title:Outstanding Researcher Award 2009-10
Investigator(s):Yuen RMF
Department:Medicine
Source(s) of Funding:Outstanding Researcher Award
Start Date:12/2010


List of Research Outputs



Researcher : Yuen RMF

Project Title:An open label study of adefovir dipivoxil for the treatment of patients with chronic hepatitis B (CHB) related advanced fibrosis or cirrhosis
Investigator(s):Yuen RMF
Department:Medicine
Source(s) of Funding:Glaxo Wellcome Hong Kong Ltd. - General Award
Start Date:07/2005


Project Title:Randomized, open-label, comparative study to evaluate early viral load reductions and exploratory viral kinetics following administration of entecavir or adefovir in nucleoside-naïve adults with chronic hepatitis B infection
Investigator(s):Yuen RMF
Department:Medicine
Source(s) of Funding:Bristol-Myers-Squibb (HK) - General Award
Start Date:01/2006


Project Title:A phase I, multi-centre, randomised, placebo-controlled, dose escalation study to assess the local and systemic tolerability of the therapeutic DNA plasmid pdpSC18 vaccine administered by particle mediated epidermal delivery using the powderject ND 10 delivery system in subjects with chronic hepatitis B infection
Investigator(s):Yuen RMF
Department:Medicine
Source(s) of Funding:PowderMed Ltd - General Award
Start Date:11/2006


Project Title:Significance of HBV DNA in the natural history of chronic hepatitis B: impact on disease outcome including significant fibrosis and hepatocellular carcinoma
Investigator(s):Yuen RMF
Department:Medicine
Source(s) of Funding:Bristol-Myers-Squibb (HK) - General Award
Start Date:09/2007


Project Title:Outstanding Researcher Award 2009-10
Investigator(s):Yuen RMF
Department:Medicine
Source(s) of Funding:Outstanding Researcher Award
Start Date:12/2010


List of Research Outputs

Bazerbachi F., Haffar S., Wang Z., González J.C., Arias-Loste M.T., Crespo J., Darwish-Murad S., Ikram M.A., Olynyk J.K., Gan E., Petta S., Berzuini A., Prati D., de Lédinghen W., Wong V.W., Del Poggio P., Chávez-Tapia N.C., Chen Y.P., Cheng P.N., Yuen R.M.F., Das K., Chowdhury A., Caballeria L., Fabrellas N., Ginès P., Kumar M., Sarin S.K., Conti F., Andreone P., Sirli R., Cortez-Pinto H., Carvalhana S., Sugihara T., Kim S.U., Parikh P., Chayama K., Corpechot C., Kim K.M., Papatheodoridis G., Alsebaey A., Kamath P.S., Murad M.H. and Watt K., Range of Normal Liver stiffness and Predictors of Suspected Advanced Fibrosis in Apparently Healthy Individuals: A Pooled Analysis of 16,082 Participants, Clinical Gastroenterology and Hepatology. 2018.
Chen T., Yang Z.Y., Li J., Han T., Hu J.H., Xin S.J., Choudhury A., Al-Mahtab M., Nan Y.M., Tan S.S., Hamid S.S., Subha A., Jafri W., Lee G.H., Ghazinian H., Chawla Y., Yuen R.M.F., Jia J.D., Abbas Z., Devarbhavi H., Dokmeci A.K., Amarapurkar D., Kumar M., Lesmana L.A., Lau G., Yokosuka O., Duan Z.P., Guo W., Ma K., Zhang Z.W., Sarin S.K. and Ning Q., Complication is a major risk factor for mortality of cirrhotic hepatitis B virus-related acute-on-chronic liver failure patients: A multi-national study from Asian-pacific region, Journal of hepatology : the journal of the European Association for the Study of the Liver. 2019, 701: E459.
Chen T., Ma K., Yang Z.Y., Duan Z.P., Li J., Chen Y., Han T., Hu J.H., Choudhury A.K., Al Mahtab M., Xin S.J., Nan Y.M., Tan S.S., Hamid S.S., Jafri S.M.W., Butt A., Lee G.H., Ghazinian H., Chawla Y.K., Yuen R.M.F., Jia J.D., Abbas Z., Devarbhavi H., Dokmeci A., Amarapurkar D.N., Lesmana L.A., Lau G.K.K., Yokosuka O., Guo W., Sarin S.K., Ning Q. and the APASL ACLF working party .., Validation of TPPM Score in Predicting Short-Term Survival in HBV-ACLF Patients: A Multinational Study from APASL ACLF Research Consortium (AARC), Hepatology. 2018, 68: 193A-194A.
Cheung T.T., Chiu W.Y.J., Yuen R.M.F., Lam K.S.L., Cheung B.M.Y., Feng H.P., Yeh W.W., Wang J.D., Li W.T., Zhao X.M., Wang Z.Q. and Mu S.M., A Phase I, Single- and Multiple-dose Study to Evaluate the Pharmacokinetics of Elbasvir and Grazoprevir in Healthy Chinese Participants” [Clinical Therapeutics 40 (2018) 719–732], Clinical Therapeutics. 2018, 40: 719-732.
Devarbhavi H., Choudhury A.K., Sharma M.K., Maiwall R., AI Mahtab M., Rahman S., Chawla Y.K., Dhimusejaan R.K., Duseja A., Taneja S., Ning Q., Jia J.D., Duan Z., Yu C., Eapen C.E., Goel A., Tan S.S., Hamid S.S., Butt A.S., Jafri W., Kim D.J., Hu J.H., Sood A., Midha V., Shukia A., Ghazinian H., Sahu M.K., Treeprasertsuk S., Lee G.H., Lim S.G., Lesmana L.A., Lesmana C.R., Shah S., Kala C., Abbas Z., Sollano J.D., Prasad V.G.M., Payawa D.A., Dokmeci A.K., Rao P.N., Shrestha A., Lau G.K., Yuen R.M.F., Saraswa V.A., Shiha G., Yokosuka O., Kedarisetty C.K., Jain P., Bhatia P. and Sarin S.K., Drug-Induced Acute-on-Chronic Liver Failure in Asian Patients, The American Journal of Gastroenterology. 2019, 114: 929-937.
Fung J.Y.Y., Chok K.S.H., Chan A.C.Y., Dai W.C., She W.H., Sin S.L., Ma K.W., Ng K.C.K., Wong C.L.T., Cheung T.T., Seto W.K.W., Lai C.L., Lo C.M. and Yuen R.M.F., High Predictive value of MELD for short-term mortality in severe acute flares of chronic hepatitis B, Hepatology. 2018, 68: 1211A-1211A.
Fung J.Y.Y., Wong D.K.H., Tanaka Y., Lo C.L.R., Wong C.L.T., Chok K.S.H., Chan A.C.Y., Cheung T.T., Dai W.C., Ng K.C.K., Ng K.T.P., Man K., Ng I.O.L., Seto W.K.W., Lai C.L., Yuen R.M.F. and Lo C.M., Quantitative hepatitis B surface antigen in predicting recurrence of hepatitis B-related hepatocellular carcinoma after liver transplantation, Hepatoma Research. 2018, 4: 62.
Fung J.Y.Y., Chok K.S.H., Wong C.L.T., Dai W.C., Chan A.C.Y., Sin S.L., She W.H., Ma K.W., Ng K.C.K., Seto W.K.W., Yuen R.M.F. and Lo C.M., Risk Factors for Graft Steatosis after Liver Transplantation using Controlled Attenuation Parameter Measurements, Transplantation. 2018, 102: S863.
Gane E.,