Dept of Orthopaedics and Traumatology

DEPT OF ORTHOPAEDICS AND TRAUMATOLOGY

Researcher : Abbah SA

List of Research Outputs

Abbah S.A., Lu W.W., Luk K.D.K., Cheung K.M.C., Liu W., Chan D., Li Z. and Leong J.C.Y., New Bone Formation by Injected With Osteogenic Cells Confined in Sodium Alginate Microcapsules, The XXIII SICOT/SIROT Triennial World Congress held in Istanbul, Turkey, September 2-9, 2005.

Abbah S.A., Lu W.W., Cheung K.M.C., Zhao F., Chan D., Liu W.G., Li Z., Leong J.C.Y. and Luk K.D.K., Polymer encapsulated human osteoblastic cells form ectopic bone in mice, 52nd Annual Meeting of Orthopaedic Research Society, Chicago, Illinois, March 19-22, 2006.

Li Z., Lu W.W., Ni G., Lam W.M.R., Chan D., Abbah S.A., Yang F., Cheung K.M.C. and Luk K.D.K., Strontium combined with calcium increases vertebral bone mineral density and stiffness in goats, 25th Annual Congress of the Hong Kong Orthopaedic Association, Nov 19-20 2005, Hong Kong. 2005.

Lu W.W., Abbah S.A., Cheung K.M.C., Chan D., Li Z.Y., Leong J.C.Y. and Luk K.D.K., Ectopic bone formation from Polymer-encapsulated osteogenic cells, 25th Annual Congress of the Hong Kong Orthopaedic Association, Nov 19-20 2005, Hong Kong. 2005.

Researcher : Abbah SA

List of Research Outputs

Researcher : Aladin KDM

List of Research Outputs

Aladin K.D.M., Lu W.W., Cheung K.M.C., Yeung K.W.K. and Chan D., Impact of Trp2 allele mutation of alpha-2 chain in collagen IX on the structural integrity of human annulus fibrosus, European Cells and Materials Symposium: Spinal Motion Segment: From Basic Science to Clinical Application, 4th to 7th July, 2005. Davos, Switzerland. 2005.

Wang Y.J., Shi Q., Lu W.W., Cheung K.M.C., Aladin K.D.M., Li T.F., Dong Y.F., Zhou C.J., Zhou Q., Hu Z.J., Liu M., Bian Q., Li C.G., Luk K.D.K. and Leong J.C.Y., Cervical intervertebral disc degeneration induced by unbalanced dynamic and static forces: A novel in vivo rat model, Spine. 2006, 31(14): 1532-1538.

Researcher : Aladin Kaderbatcha DM

List of Research Outputs

Aladin Kaderbatcha D.M., Lu W.W., Cheung K.M.C., Yeung K.W.K. and Chan D., Impact of the Trp2 allele mutation of the alpha-2 chain in collagen IX on the structural integrity of human annulus fibrosus., European Cells and Material: ECM VI/SRN I Spinal Motion Segment: From basic science to clinical application. Davos, Switzerland, July 2005 . 2005.

Researcher : Arvinte D

List of Research Outputs

Cheung W.Y., Arvinte D., Cheung K.M.C. and Luk K.D.K., Neurological recovery after surgical decompression in patients with cervical spondylotic myelopathy: a prospective study, 25th Annual Congress of the Hong Kong Orthopaedic Association. 2005.

Researcher : Au YK

List of Research Outputs

Au Y.K., Wynn S.L., Cheung K.M.C. and Cheah K.S.E., Foxa2 minimal notochord enhancer element mediates Cre expression in the node and notochord, Mechanisms of Development, 15th International Society of Developmental Biologist Congress 2005, 3-7 September 2005 Sydney, Australia. 2005.

Au Y.K., Cheung K.M.C. and Cheah K.S.E., In vivo functional analysis of SOX9 by conditional expression of a mutant SOX9, SOx9^Y440X, 10th Research Postgraduate Symposium, Faculty of Medicine, HKU. 3 Dec. 2005.

Researcher : Cao Y

List of Research Outputs

Cao Y., Chen C. and Hu Y., Application of independent component analysis to ECG cancellation in surfaceelectromyography measurement., Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2005, 22: 686-9.

Researcher : Chan CCY

List of Research Outputs

Chan C.C.Y., Luk K.D.K. and Cheah K.S.E., Understanding the function of the SEDL gene and the molecular pathogenesis of spondyloepiphyseal dysplasia tarda, 10th Research Postgraduate Symposium, Faculty of Medicine, HKU. 2005.

Researcher : Chan YL

List of Research Outputs

Yeung K.W.K., Chan Y.L., Chan S.C.W., Liu X.Y., Chung C.Y., Chu P.K., Lu W.W., Luk K.D.K., Chan D. and Cheung K.M.C., Suppression of nickel release in nickel-titanium alloys by plasma immersion ion implantation surface treatment: towards a new generation of "smart" orthopaedic implants, 33rd IEEE International Conference on Plasma Science, Traverse City, Michigan, U.S.A., June 4-8, 2006.

Researcher : Chen C

List of Research Outputs

Cao Y., Chen C. and Hu Y., Application of independent component analysis to ECG cancellation in surfaceelectromyography measurement., Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2005, 22: 686-9.

Researcher : Chen Y

List of Research Outputs

Cheung K.M.C., Chen Y., Karppinen J., Chan D., Jim J.J.T., Luk K.D.K., Ala-Kokko L., Leong J.C.Y., Ott J., Sham P.C., Cheah K.S.E. and Song Y., Association of the Taq I allele in vitamin D receptor with degenerative disc disease and disc bulge in Chinese, Spine. 2006, 31(10): 1143-8.

Qian W.P., Tan Y., Chen Y., Peng Y., Li Z., Lu G.X., Lin M.C., Kung H., He M.L. and Shing L.K., Rapid quantification of semen hepatitis B virus DNA by real-time polymerase chain reaction, World Journal of Gastroenterology. 2005, 11(34): 5385-9.

Researcher : Cheung KMC

Project Title:	Genetic basis of degenerative disc disease in Chinese
Investigator(s):	Cheung KMC, Cheah KSE, Leong JCY, Chan D, Luk KDK, Yip SP
Department:	Orthopaedics and Traumatology
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	09/2001
Completion Date:	08/2005

Abstract:

To determine the contribution of COL9 mutations and other genetic factors to risk for DDD in Southern Chinese individuals.

Project Title:	Setting Up of a Stem Cell Research Programme for Musculoskeletal Tissue Repair
Investigator(s):	Cheung KMC, Chan D
Department:	Orthopaedics and Traumatology
Source(s) of Funding:	The University of Hong Kong Foundation Seed Grant
Start Date:	07/2003

Abstract:

To explore a novel method of intervertebral disc repair by implanting autologous MSCs into the degenerated intervertebral disc using a rabbit model.

Project Title:	The impact of the COL9A2 Q326W allele on intervertebral disc structure and degeneration
Investigator(s):	Cheung KMC
Department:	Orthopaedics and Traumatology
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

N/A

Project Title:	The impact of the COL9A2 Q326W allele on intervertebral disc structure and degeneration
Investigator(s):	Cheung KMC, Cheah KSE, Lu WW, Chan D, Luk KDK
Department:	Orthopaedics and Traumatology
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	01/2005

Abstract:

To collect and store degenerated and non-degenerated human intervertebral discs and DNA; to examine these retrieved specimens for expression of [alpha]2(IX)^Trp, collagen IX cross-linking abnormalites, cellular and extracellular matrix abnormalties and alternations in mechanical properties.

Project Title:	Intervertebral disc regeneration by use of mesenchymal stem cells
Investigator(s):	Cheung KMC
Department:	Orthopaedics and Traumatology
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2006

Abstract:

N/A

Project Title:	Intervertebral disc regeneration by use of mesenchymal stem cells
Investigator(s):	Cheung KMC, Chan D, Wu EX, Luk KDK
Department:	Orthopaedics and Traumatology
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	01/2006

Abstract:

(1) What is the fate of the transplanted MSCs within the IVD; (2) at what stage of degeneration is cell therapy most effective; (3) could allogeneic MSCs be used for transplantation; (4) what are the long term effects of transplanted MSCs.

Project Title:	New compounds for intervertebral disc regeneration by Chemical Genetics
Investigator(s):	Cheung KMC, Leung YL, Kao RYT, Chan D
Department:	Orthopaedics and Traumatology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2006

Abstract:

Low back pain is a significant cause of morbidity and disability. It is one of the most frequent reasons for clinic visits, loss of work hours and billions of dollars of expenditure in treatment and wage compensation. Although low back pain is complex in aetiology, chronic low back pain is commonly associated with degeneration of the intervertebral disc (IVD). Patients with severe IVD degeneration and pain often require surgery with its associated morbidity.Adult IVD cells have similar biological phenotype to chondrocytes1, using this knowledge various biological therapies for IVD regeneration have emerged. This includes injection of biomolecules such as OP-1/BMP-2/GDF-5 2-4 and adenoviral delivery of Sox9 gene 5 into degenerated discs. Chemical genetics is an emerging technique that uses small chemical compounds to alter the functions of proteins to which they bind. The principle is similar to how genes are manipulated in knock-out or transgenic animal models to understand the function of a particular gene; the downstream effects of alterations of these proteins can be evaluated to understand the function of the protein and its pathway, hence the term "Chemical Genetics". It is thus used to identify which proteins regulate different biological processes, to understand in molecular detail how proteins perform their biological functions, and to identify small compounds that may be of medical value. Through strategic design of screening assays, this technology has been successfully employed to identify potential pharmaceuticals for cancers 6, 7, diabetes 8, cardiovascular diseases 9, and neurodegeneration 10, 11. The Department of Microbiology at The University of Hong Kong has the only high throughput chemical genetics screening platform in Asia, and they have successfully used this technology to identify compounds that have anti-SARS-coV and anti-angiogenesis activity 12, 13.Using the principle of "Forward Genetics", we aim to perform a primary screen of a library of over 50,000 small compounds using goat chondrocytes, and to select those that are able to maintain or increase proteoglycan levels. Recent evidence that a number of molecular pathways are involved in IVD degeneration, and that an orally administered drug, Esculetin can reverse IVD degeneration in rabbits 14, would support that other small compounds and pathways that may act similarly or even more specifically can be identified. Reference list:1. Hunter, C. J., Matyas, J. R. & Duncan, N. A. Tissue Eng 9, 667-77 (2003).2. An, H. S. et al. Spine 30, 25-31; discussion 31-2 (2005).3. Li, J., Yoon, S. T. & Hutton, W. C. J Spinal Disord Tech 17, 423-8 (2004).4. Li, X., Leo, B. M., Beck, G., Balian, G. & Anderson, G. D. Spine 29, 2229-34 (2004).5. Paul, R. et al. Spine 28, 755-63 (2003).6. Lam, K. S. Anticancer Drug Des 12, 145-67 (1997).7. Remiszewski, S. W. Curr Med Chem 10, 2393-402 (2003).8. Shi, G. Q. et al. J Med Chem 48, 4457-68 (2005).9. Bush, E. et al. Proc Natl Acad Sci U S A 101, 2870-5 (2004).10. Apostol, B. L. et al. Proc Natl Acad Sci U S A 100, 5950-5 (2003).11. Massa, S. M., Xie, Y. & Longo, F. M. J Mol Neurosci 19, 107-11 (2002).12. Kao, R. Y. et al. Chem Biol 11, 1293-9 (2004).13. Kao, R. Y. et al. Proc Natl Acad Sci U S A 99, 10066-71 (2002).14. Masuda, K. & An, H. in European Cells and Materials 38 (2005).

List of Research Outputs

Abbah S.A., Lu W.W., Luk K.D.K., Cheung K.M.C., Liu W., Chan D., Li Z. and Leong J.C.Y., New Bone Formation by Injected With Osteogenic Cells Confined in Sodium Alginate Microcapsules, The XXIII SICOT/SIROT Triennial World Congress held in Istanbul, Turkey, September 2-9, 2005.

Abbah S.A., Lu W.W., Cheung K.M.C., Zhao F., Chan D., Liu W.G., Li Z., Leong J.C.Y. and Luk K.D.K., Polymer encapsulated human osteoblastic cells form ectopic bone in mice, 52nd Annual Meeting of Orthopaedic Research Society, Chicago, Illinois, March 19-22, 2006.

Aladin K.D.M., Lu W.W., Cheung K.M.C., Yeung K.W.K. and Chan D., Impact of Trp2 allele mutation of alpha-2 chain in collagen IX on the structural integrity of human annulus fibrosus, European Cells and Materials Symposium: Spinal Motion Segment: From Basic Science to Clinical Application, 4th to 7th July, 2005. Davos, Switzerland. 2005.

Aladin Kaderbatcha D.M., Lu W.W., Cheung K.M.C., Yeung K.W.K. and Chan D., Impact of the Trp2 allele mutation of the alpha-2 chain in collagen IX on the structural integrity of human annulus fibrosus., European Cells and Material: ECM VI/SRN I Spinal Motion Segment: From basic science to clinical application. Davos, Switzerland, July 2005 . 2005.

Au T.Y.K., Wynn S.L., Cheah K.S.E. and Cheung K.M.C., The use of a mouse model to understand the role of SOX9 in campomelic dysplasia and the notochord, 25th Annual Congress of the Hong Kong Orthopaedic Association, Nov 19-20 2005, Hong Kong. 2005.

Au Y.K., Wynn S.L., Cheung K.M.C. and Cheah K.S.E., Foxa2 minimal notochord enhancer element mediates Cre expression in the node and notochord, Mechanisms of Development, 15th International Society of Developmental Biologist Congress 2005, 3-7 September 2005 Sydney, Australia. 2005.

Au Y.K., Cheung K.M.C. and Cheah K.S.E., In vivo functional analysis of SOX9 by conditional expression of a mutant SOX9, SOx9^Y440X, 10th Research Postgraduate Symposium, Faculty of Medicine, HKU. 3 Dec. 2005.

Chan B.P., Hui T.Y., Chan C.M., So K.F., Lu W.W., Cheung K.M.C., Salomatina E. and Yaroslavsky A., Photochemical crosslinking for collagen-based scaffolds - A study on optical properties, mechanical properties, stablility and haematocompatibility, Tissue Engineering. USA, Mary Ann Liebert, Inc., 2006.

Chan D., Tsang K.Y., Cheslett D., Chan W.C.W., So C.L., Kwan K.M., Hunziker E.B., Yamada Y., Bateman J.F., Cheung K.M.C. and Cheah K.S.E., Endoplasmic reticulum stress and reprogramming of hypertrophic chondrocytes, Gordon Research Conference: Collagen. New London, New Hampshire USA, July. 2005.

Chan D., Ho G. and Cheung K.M.C., Stem cell therapy for intervertebral disc degeneration, The Croucher Foundation Advanced Study Institute on Stem Cell Research, Nov 14-15. 2005.

Chan D. and Cheung K.M.C., The effect of severity of degeneration on mesenchymal stem cells' ability to regenerate the intervetebral disc: a rabbit model, Hansjoerg Wyss Foundation Oral Presentation Award European Cells and Materials VI / SRN I Spinal Motion Segment: From Basic Science to Clinical Application, July 4-7 2005. 2005.

Chan D., Ho G., Leong V.Y.L. and Cheung K.M.C., The effect of severity of disc degeration on mesenchymal stem cell's ability to regenerate the intervertebral disc., European Cells and Material: ECM VI/SRN I Spinal Motion Segment: From basic science to clinical application. Davos, Switzerland, July 2005 . 2005.

Chan Y.L., Wang M., Lu W.W. and Cheung K.M.C., An investigation into a surface-treated shape memory alloy for orthopaedic applications, Proceedings of the International Symposium on Quality of Bone and Scaffold Materials Evaluated by microCT, pQCT and MRI. Hong Kong, The Chinese University of Hong Kong, 2005, 163.

Cheung K.M.C., Allograft Cervical Disc Replacement, Spine Connection 2006 organised by Malmo University Hospital, Malmo, Switzerland. April 27-28, 2006.

Cheung K.M.C., Anterior approach from C1 to the cervicothoracic junction, AOSpine Advanced Course, Phuket, Thailand, March 16-18, 2006.

Cheung K.M.C., Anterior approaches to cervical spine, en-bloc spondylectomy, recent advances in treatment of severe pediatric scoliosis, Faculty AO Spine Advanced Spine Course, Phuket, Thailand, March, 16-18, 2006. 2006.

Cheung K.M.C., Chen Y., Karppinen J., Chan D., Jim J.J.T., Luk K.D.K., Ala-Kokko L., Leong J.C.Y., Ott J., Sham P.C., Cheah K.S.E. and Song Y., Association of the Taq I allele in vitamin D receptor with degenerative disc disease and disc bulge in Chinese, Spine. 2006, 31(10): 1143-8.

Cheung K.M.C. and Guo C.A.T.H.Y., Comparison of the effect of non-selective NSAID and Cyclooxygenase-2 (COX-2) Selective NSAID on bone formation - Implications for Spinal Fusion, Moe basic science poster award Annual Meeting of the Scoliosis Research Society, Miami, USA, Oct 2005. 2005.

Cheung K.M.C., Yeung K.W.K., Chung J.C.Y. and Lu W.W., Device for correcting spinal deformities, Chinese Non-provisional Patent (No. 03824606.6). Filed: 16 November, 2005. 2005.

Cheung K.M.C., Duel: Why I use nagivation vs why I don't , AOSpine Degenerative Lumbar Spine and Deformity Course, Davos, Switzerland, December 11-16, 2005.

Cheung K.M.C., En bloc resection, AOSpine Advanced Course, Phuket, Thailand, March 16-18, 2006.

Cheung K.M.C., Genetics of Degenerative Disc Disease, The Lumbar Intervertebral Disc. Current Concepts in Nonfusion Technology, Denver, Colorado, USA, April 29-30, 2006.

Cheung K.M.C., Genetics of degenerative disc disease, European Cells and Materials Symposium (ECMVI): Spinal motion segment: from basic science to clinical application, Davos, Switzerland, July 4-7, 2005. 2005.

Cheung K.M.C., Yeung K.W.K., Lu W.W. and Luk K.D.K., Gradual deformity correction by use of the super elastic property of nickel-titanium alloy: in-vivo demonstration in a goat model, 40th Annual Meeting of Scoliosis Research Society, Miami, Florida, USA, October 27-30, 2005.

Cheung K.M.C. and Chooi Y.S., Hip adduction differences in adolescent idiopathic scoliosis: a cause or effect of scoliosis?, 25th Annual Congress of the Hong Kong Orthopaedic Association, Nov 19-20 2005, Hong Kong. 2005.

Cheung K.M.C., Lu D., Zhang H. and Luk K.D.K., In-vivo demonstration of the effectiveness of thoracoscopic anterior release using the fulcrum bending radiograph: a report of five cases, European Spine Journal. 2005, 21: 1-5.

Cheung K.M.C., Intervertebral Disc Regeneration & Tissue Engineering, The Lumbar Intervertebral Disc. Current Concepts in Nonfusion Technology, Denver, Colorado, USA, April 29-30, 2006.

Cheung K.M.C., Intervertebral Disc Transplantation, The Lumbar Intervertebral Disc. Current Concepts in Nonfusion Technology, Denver, Colorado, USA, April 29-30, 2006.

Cheung K.M.C., Intervertebral disc regeneration and tissue engineering, AOSpine Trauma and Degenerative Course, Davos, Switzerland, December 11-16, 2005.

Cheung K.M.C., Intervetebral disc regeneration, Federation of the Medical Societies of Hong Kong, Annual Scientific Meeting, June 10, 2006. 2006.

Cheung K.M.C., MRI Findings in Disc Degeneration , The Lumbar Intervertebral Disc. Current Concepts in Nonfusion Technology, Denver, Colorado, USA, April 29-30, 2006.

Cheung K.M.C., Management of severe pediatric spinal deformities, Hong Kong Orthopaedic Association Annual Congress, November 19-20, 2005. 2005.

Cheung K.M.C., Memory Alloy Technology in Spinal Implants, Spine Connection 2006 organised by Malmo University Hospital, Malmo, Switzerland. April 27-28, 2006.

Cheung K.M.C., Natural history and aetiology of AIS, AOSpine Advanced Course, Hong Kong, September 21-23, 2005. 2005.

Cheung K.M.C., Odontoid fractures, AOSpine Advanced Course, Hong Kong, September 21-23, 2005. 2005.

Cheung K.M.C., Osteoporotic fractures, AOSpine Advanced Course, Hong Kong, September 21-23, 2005. 2005.

Cheung K.M.C., Yeung K.W.K., Lu W.W. and Luk K.D.K., Prediction of spinal flexibility in adolescent idiopathic scoliosis: a quantitative analysis by in-vivo correction force measurements, SICOT/SIROT 2005 XXIII World Congress, Istanbul, Turkey, September 2-9, 2005.

Cheung K.M.C., Recent advances in management of severe pediatric, AOSpine Advanced Course, Phuket, Thailand, March 16-18, 2006.

Cheung K.M.C., Selection of fusion levels using fulcrum bending radiograph, International Symposium on Spinal Deformities and Minimally Invasive Spinal Surgery, Changhai Hospital, Shanghai, October 16, 2005. 2005.

Cheung K.M.C., Yeung K.W.K., Chung J.C.Y. and Lu W.W., Shape memory material and method of making the same (Heat treatment protocol), Japan Non-provisional Patent (No. 100064746). Filed 19 April 2004. Publication date: 14 October 2005 . 2005.

Cheung K.M.C., Strategy for posterior approaches, AOSpine Advanced Course, Phuket, Thailand, March 16-18, 2006.

Cheung K.M.C., Surgical techniques, AOSpine Trauma and Degenerative Course, Davos, Switzerland, December 11-16, 2005.

Cheung K.M.C., Talks on management of TB spine and osteoporotic spinal fractures, International Spine Symposium, The Medical College of Qingdao University, Qingdao, China, October 14-15, 2005. 2005.

Cheung K.M.C., Jim J.J.T., Noponen-Hietala N., Ott J., Karppinen J., Sahraravand A., Luk K.D.K., Yip S.P., Sham P.C., Song Y., Leong J.C.Y., Cheah K.S.E., Ala-Kokko L. and Chan D., The Genetics of intervertebral disc degenertation, European Cells and Material: ECM VI/SRN I Spinal Motion Segment: From basic science to clinical application. Davos, Switzerland, July . 2005.

Cheung K.M.C., Wang T., Carl A., Hu Y.G. and Leong J.C.Y., The effect of pinealectomy on scoliosis development in young non-human primates, SICOT 3rd Prize at the SICOT/SIROT 2005 XXIII World Congress, Istanbul, Turkey, September 2-9, 2005. 2005.

Cheung K.M.C., Wang T., Carl A., Hu Y.G. and Leong J.C.Y., The effect of pinealectomy on scoliosis development in young non-human primates, SICOT/SIROT 2005 XXIII World Congress, Istanbul, Turkey, September 2-9, 2005.

Cheung K.M.C., Wang T., Poon A.M.S., Carl A., Tranmer B., Hu Y.G., Luk K.D.K. and Leong J.C.Y., The effect of pinealectomy on scoliosis development in young non-human primates, Spine. 2005, 30(18): 2009-2013.

Cheung K.M.C., Ho G., Leung V. and Chan D., The effect of severity of degeneration on intervertebral disc regeneration by autologous mesenchymal stem cells, The 6th Combined Congress of the Spine and Paediatric Orthopaedic Sections of APOA, Taipei, Taiwan. Nov 24-27 2005.

Cheung K.M.C., Thoracoscopic surgery, AOSpine Advanced Course, Hong Kong, September 21-23, 2005. 2005.

Cheung K.M.C., Lu W.W., Luk K.D.K., Wong C.T., Chan D., Shen J.X., Qiu G.X., Zheng Z.M., Li C.H., Liu S.L., Chan W.K. and Leong J.C.Y., Vertebroplasty by use of a strontium containing bioactive bone cement, Spine (Focus Issue). 2005, 30(17S): S84-S91.

Cheung K.M.C., Ho G., Chan D. and Leong V.Y.L., regeneration of nucleus pulposus after disectomy by autologous mesenchymal stem cells: a rabbit model, European Cells and Material: ECM VI/SRN I Spinal Motion Segment: From basic science to clinical application. Davos, Switzerland, July 2005 . 2005.

Cheung W.Y., Arvinte D., Cheung K.M.C. and Luk K.D.K., Neurological recovery after surgical decompression in patients with cervical spondylotic myelopathy: a prospective study, 25th Annual Congress of the Hong Kong Orthopaedic Association. 2005.

Coe J.D. and Cheung K.M.C., Summary statement on biomaterials, Spine (Focus Issue). 2005, 30(17S): S75.

Guo C., Irwin M.G., Chan D., Tipoe G. and Cheung K.M.C., The role of cylooxygenase 1 and 2 in fracture repair , 52nd Annual Meeting of Orthopaedic Research Society, Chicago, Illinois, March 19-22, 2006.

Guo X., Cheung K.M.C., Chan D. and Irwin M.G., Comparison of the effect of non-selective NSAID and Cycloosygenoase-2 (COX-2) selective NSAID on bone formation - implications for spinal fusion, 40th Annual Meeting of Scoliosis Research Society, Miami, Florida, USA, October 27-30, 2005.

Guo X., Irwin M.G., Chan D., Tipoe G.L. and Cheung K.M.C., Differential functions of cyclooxygenase 1 and 2 in bone repair, European Cells and Materials. 2005, 10(3): 56.

Guo X., Irwin M.G., Cheung K.M.C., Chan D. and Tipoe G.L., The Role of Cyclooxygenase 1 and 2 in Bone Repair, 10th Research Postgraduate Symposium, Faculty of Medicine, HKU, December 3, 2005.

Ho D.W.H., Cheung K.M.C., Chan D., Karppinen J., Yip S.P., Ott J., Luk K.D.K., Leong J.C.Y., Cheah K.S.E., Sham P.C. and Song Y., Linkage Analysis on familial Early-onset Degenerative Disc Disease(DDD), Hugo, HGM2006, 31 May - 3 June 2006 Helsinki, Finland.. 2006.

Ho J.P.Y., Wu S.L., Poon R.W.Y., Chung C.Y., Tjong S.C., Chu P.K., Yeung K.W.K., Lu W.W., Cheung K.M.C. and Luk K.D.K., Oxygen plasma treatment to restrain nickel out diffusion from porous nickel titanium orthopedic materials, 5th Asian-European International Conference on Plasma Surface Engineering, Qingdao, China, September 12-16, 2005.

Hui T.Y., Ho G., Cheung K.M.C., Chan D., Cheung W.L. and Chan B.P., Rabbit bone marrow derived mesenchymal stem cells induced collagen gel contraction-fabrication of tissue-like structures with different cell densities, Tissue Engineering. May Ann Liebut, Inc., 2005, 110.

Jim J.J.T., Noponen-Hietala N., Cheung K.M.C., Ott J., Karppinen J., Sahraravand A., Luk K.D.K., Yip S.P., Sham P.C., Song Y., Leong J.C.Y., Cheah K.S.E., Ala-Kokko L. and Chan D., The TRP2 allele of COL9A2 is an age-dependent risk factor for the development and severity of intervertebral disc degeneration, Spine. 2005, 30: 2735-2742.

Leung V.Y.L., Ho G., Chan D. and Cheung K.M.C., The effect of severity of degeneration on intervertebral disc regeneration by autologous mesenchymal stem cells, 25th Annual Congress of the Hong Kong Orthopaedic Association, Nov 19-20 2005, Hong Kong. 2005.

Leung Y.L., Chan D. and Cheung K.M.C., Regeneration of intervertebral disc by mesenchymal stem cells: Potentials, limitations, and future direction, Eur Spine J. 2006, 15 Suppl 15: 406-13.

Leung Y.L., Ho G., Chan D. and Cheung K.M.C., The effect of severity of degeneration on intervertebral disc regeneration by use of mesenchymal stem cells, 52nd Annual Meeting of Orthopaedic Research Society, Chicago, Illinois, March 19-22, 2006.

Leung Y.L., Ho G., Cheung K.M.C. and Chan D., The effect of severity of degeneration on intervertebral disc regeneration by use of mesenchymal stem cells, European Cells & Materials Conference, Davos, Switzerland. 2005.

Li Z., Lu W.W., Ni G., Lam W.M.R., Chan D., Abbah S.A., Yang F., Cheung K.M.C. and Luk K.D.K., Strontium combined with calcium increases vertebral bone mineral density and stiffness in goats, 25th Annual Congress of the Hong Kong Orthopaedic Association, Nov 19-20 2005, Hong Kong. 2005.

Lu W.W., Abbah S.A., Cheung K.M.C., Chan D., Li Z.Y., Leong J.C.Y. and Luk K.D.K., Ectopic bone formation from Polymer-encapsulated osteogenic cells, 25th Annual Congress of the Hong Kong Orthopaedic Association, Nov 19-20 2005, Hong Kong. 2005.

Lu W.W., Wong C.T., Cheung K.M.C., Leong J.C.Y. and Luk K.D.K., In vitro mineralization of strontium-containing hydroxyapatite bioactive bone cement, SICOT/SIROT 2005 XXIII World Congress, Istanbul, Turkey, September 2-9, 2005.

Lu W.W., Ni G., Li Z., Tan B., Cheung K.M.C., Ngan A.H.W., Leong J.C.Y. and Luk K.D.K., Nanostructural and nanomechanics of the bone-cement interface in vivo, 25th Annual Congress of the Hong Kong Orthopaedic Association, Nov 19-20 2005, Hong Kong. 2005.

Luk K.D.K., Ruan D.K., Lu D., Chow D.H.K. and Cheung K.M.C., Allogeneic intervertebral disc transplantation: Results of pre-clinical and clinical studies, European Cells and Materials. 2005, 10 (Supplement 3): 8.

Ni G., Lu W.W., Tang B., Ngan A.H.W., Chiu P.K.Y., Cheung K.M.C., Li Z. and Luk K.D.K., Mechanical properties of interfaces between bone and strontium-containing hydroxyapatite bone cement under non- and weight-bearing conditions by nanoindentation, 52nd Annual Meeting of Orthopaedic Research Society, Chicago, Illinois, March 19-22, 2006.

Poon R.W., Ho J.P., Liu X.Y., Chung C.Y., Chu P.K., Yeung K.W.K., Lu W.W. and Cheung K.M.C., Formation of Titanium Nitride barrier layer in Nickel-Titanium shape memory alloys by nitrogen plasma immersion ion implantation for better corrosion resistance, Thin Solid Films. 2005, 488: 20-25.

Poon R.W., Ho J.P., Luk C.M., Liu X.Y., Chung C.Y., Chu P.K., Yeung K.W.K., Lu W.W. and Cheung K.M.C., Improvement of Corrosion Resistance of NiTi Orthopedic Materials by Carbon Plasma Immersion Ion Implantation, Nuclear Instruments and Methods in Physics Research B. 2006, 242: 270-274.

Poon R.W.Y., Ho J.P.Y., Liu X.Y., Chung C.Y., Tjong P.K., Chu P.K., Yeung K.W.K., Lu W.W. and Cheung K.M.C., Improvement of surface properties of orthopedic nickel-titanium shape memory alloys by nitrogen plasma immersion ion implantation, 14th International Conference on Surface Modification of Materials by Ion Beams (SMMIB), September 4-9, 2005, Kusadasi, Turkey. 2005.

Poon R.W.Y., Ho J.P.Y., Liu X.Y., Chung C.Y., Chu P.K., Yeung K.W.K., Lu W.W. and Cheung K.M.C., Improvements of anti-corrosion and mechanical properties of NiTi orthopedic materials by acetylene, nitrogen and oxygen plasma immersion ion implantation, Nuclear Instruments and Methods in Physics Research B. 2005, 237: 411-416.

Senkoylu A., Wong Y.W., Luk K.D.K. and Cheung K.M.C., Spontaneous rotational correction secondary to coronal curve correction in adolescent idiopathic scoliosis, 25th Annual Congress of the Hong Kong Orthopaedic Association, Nov 19-20 2005, Hong Kong. 2005.

Song Y., Ho D.W.H., Cheung K.M.C., Karppinen J., YIP S.P., Leong J.C.Y., Ott J., Luk K.D.K., Cheah K.S.E., Sham P.C. and Chan D., Genetic Linkage analysis of early onset degenerative disc disease in Southern Chinese., HUGO Pacific meeting & Asia-pacific Human Genetics Conference (HUGO-AP 2006), March 6-10, 2006 Academica Sinica, Taipei. 2006.

Takemitsu M., Cheung K.M.C., Wong Y.W., Cheung W.Y. and Luk K.D.K., The fifth cervical nerve root (C5) palsy after cervical Iaminoplasty and posterior fusion with instrumentation (investigation performed at the University of Hong Kong), 25th Annual Congress of the Hong Kong Orthopaedic Association, Nov 19-20 2005, Hong Kong. 2005.

To M. and Cheung K.M.C., Prospective evaluation of vertebroplasty with osteoporotic vertebral compression fracture non-union, 25th Annual Congress of the Hong Kong Orthopaedic Association. 2005.

Tsang K.Y., Chan D., Cheslett D., Chan W.C.W., So C.L., Kwan K.M., Hunziker E.B., Yamada Y., Bateman J.F., Cheung K.M.C. and Cheah K.S.E., Chondroctes Alleviate ER Stress Caused by Unfolded Proteins by Reprogramming, The British Society for Matrix Biology. 25th Anniversary Meeting Pathobiology of Bone and Cartilage. Manchester, UK, 12-13 September . 2005.

Wang Y.J., Shi Q., Lu W.W., Cheung K.M.C., Aladin K.D.M., Li T.F., Dong Y.F., Zhou C.J., Zhou Q., Hu Z.J., Liu M., Bian Q., Li C.G., Luk K.D.K. and Leong J.C.Y., Cervical intervertebral disc degeneration induced by unbalanced dynamic and static forces: A novel in vivo rat model, Spine. 2006, 31(14): 1532-1538.

Wu S.L., Liu X.M., Chung C.Y., Yeung K.W.K., Chu P.K., Chu C.L., Lu W.W. and Cheung K.M.C., Nickel relaese behavior and biocompatibility of oxidized porous NiTi, European Materials Research Society 2006 Spring Meeting, Nice, France, May 29 to June 2, 2006.

Wu S.L., Chu P.K., Liu X.M., Chung C.Y., Ho J.P., Chu C.L., Yeung K.W.K., Lu W.W., Luk K.D.K. and Cheung K.M.C., Surface Characteristics, Mechanical Properties, and Cytocompatibility of Oxygen Plasma-Implanted Porous Nickel Titanium Shape Memory Alloy, Journal of Biomedical Materials Research: Part A. 2006, 79A: 139-146.

Yee A.F.Y., Cheung K.M.C. and Chan D., Gene and Protein Expression Profiles of the Intervertebral Disc: In Health and Disease - A General Overview, 10th Research Postgraduate Symposium, Faculty of Medicine, HKU, December 3, 2005.

Yeung K.W.K., Lu W.W., Luk K.D.K. and Cheung K.M.C., A Novel design of spinal implant coupling by the use of shape memory effect of nickel titanium alloys, SICOT/SIROT 2005 XXIII World Congress, Istanbul, Turkey, September 2-9, 2005.

Yeung K.W.K., Lu W.W., Luk K.D.K. and Cheung K.M.C., A novel "smart" spinal implant locking mechanism based on nickel-titanium alloy, 40th Annual Meeting of Scoliosis Research Society, Miami, Florida, USA, October 27-30, 2005.

Yeung K.W.K., Cheung K.M.C., Lu W.W., Luk K.D.K. and Leong J.C.Y., A novel method for gradual scoliosis correction using the superelastic effect of nickel titanium alloys, SICOT/SIROT 2005 XXIII World Congress, Istanbul, Turkey, September 2-9, 2005.

Yeung K.W.K., Lu W.W., Luk K.D.K. and Cheung K.M.C., A smart locking mechanism for orthopaedic implants, 52nd Annual Meeting of Orthopaedic Research Society, Chicago, Illinois, March 19-22, 2006.

Yeung K.W.K., Lu W.W., Luk K.D.K. and Cheung K.M.C., A “Smart” Locking Mechanism For All Orthopaedic Implants, 25th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 19-20, 2005.

Yeung K.W.K., Poon R.W., Liu X.Y., Ho J.P., Chung C.Y., Chu P.K., Lu W.W., Chan D. and Cheung K.M.C., Corrosion resistance, mechanical properties and cyto-compatibility of NiTi shape memory alloys using nitrogen, and oxygen plasma immersion ion implantation, Journal of Biomedical Materials Research: Part A. 2005, 75: 256-67.

Yeung K.W.K. and Cheung K.M.C., Development of a Novel Spinal Implant for Progressive Scoliosis Correction, Young Scientist Award 2005 by The Hong Kong Institute of Science, HK, Oct 2005. 2005.

Yeung K.W.K., Poon R.W.Y., Liu X.Y., Ho J.P.Y., Chung C.Y., Chu P.Y., Lu W.W., Chan D. and Cheung K.M.C., Enhanced corrosion resistance and biocompatibility by plasma implantation of nickel-titanium alloys: An in-vitro and surface chemical study, 51st Annual Meeting of Orthopaedic Research Society, Washington DC, U.S.A., 2005.

Yeung K.W.K., Poon R.W.Y., Liu X., Ho J.P.Y., Chung C.Y., Chu P.K., Lu W.W., Chan D. and Cheung K.M.C., Nickel suppression in Ni-Ti alloys by plasma immersion ion implantation surface treatment: new materials for orthopaedic implantation, European Cells and Materials. 2005, 10(3): 78.

Yeung K.W.K., Poon R.W.Y., Liu X., Ho J.P.Y., Chung C.Y., Chu P.K., Wu W.W., Chan D. and Cheung K.M.C., Nickle suppression in Nickle-titanium alloys by plasma immersion ion implanation surface treatmentL new material for orthopaedic implanation., European Cells and Material: ECM VI/SRN I Spinal Motion Segment: From basic science to clinical application. Davos, Switzerland, July 2005 . 2005.

Yeung K.W.K., Poon R.W., Liu X.Y., Chung C.Y., Chu P.K., Lu W.W., Chan D. and Cheung K.M.C., Nitrogen Plasma Immersion Ion Implanted Nickel Titanium Alloys For Orthopedic Use, 5th Asian-European International Conference on Plasma Surface Engineering, Qingdao, China, Sept 12-16, 2005.. 2005.

Yeung K.W.K., Poon R.W.Y., Liu X.Y., Chung C.Y., Chu P.K., Lu W.W., Chan D. and Cheung K.M.C., Nitrogen plasma immersion ion implanted nickel titanium alloys for orthopedic use, 5th Asian-European International Conference on Plasma Surface Engineering, Qingdao, PR China, September 12-16. 2005.

Yeung K.W.K., Lu W.W., Luk K.D.K. and Cheung K.M.C., Progressive deformity correction using the superelastic property of nickel-titanium alloy: in-vivo demonstration in a goat model, 52nd Annual Meeting of Orthopaedic Research Society, Chicago, Illinois, March 19-22, 2006.

Yeung K.W.K., Chan Y.L., Chan S.C.W., Liu X.Y., Chung C.Y., Chu P.K., Lu W.W., Luk K.D.K., Chan D. and Cheung K.M.C., Suppression of nickel release in nickel-titanium alloys by plasma immersion ion implantation surface treatment: towards a new generation of "smart" orthopaedic implants, 33rd IEEE International Conference on Plasma Science, Traverse City, Michigan, U.S.A., June 4-8, 2006.

Yeung K.W.K., Chu P.K., Poon R.W.Y., Lu W.W. and Cheung K.M.C., Surface treated shape memory materials by the use of plasma immersion ion implantation and deposition or related ion-beam and plasma-based techniques for biomedical applications, US Non-Provisional Patent (No. 11/331264). Filed on January 11, 2006. 2006.

Yuan B., Chung J.C.Y., Yeung K.W.K. and Cheung K.M.C., Pseudoelastic porous shape memory materials for biomedical and engineering applications, US Provisional Patent filed 23 September 2005. 2005.

Researcher : Cheung WY

List of Research Outputs

Cheung W.Y., Arvinte D., Cheung K.M.C. and Luk K.D.K., Neurological recovery after surgical decompression in patients with cervical spondylotic myelopathy: a prospective study, 25th Annual Congress of the Hong Kong Orthopaedic Association. 2005.

Takemitsu M., Cheung K.M.C., Wong Y.W., Cheung W.Y. and Luk K.D.K., The fifth cervical nerve root (C5) palsy after cervical Iaminoplasty and posterior fusion with instrumentation (investigation performed at the University of Hong Kong), 25th Annual Congress of the Hong Kong Orthopaedic Association, Nov 19-20 2005, Hong Kong. 2005.

Researcher : Chiu PKY

Project Title:	The effect of bisphosphonate on established osteolytic lesions--a study of different approach and dosage in rabbit hip replacement model
Investigator(s):	Chiu PKY, Tang WM, Zhu Y
Department:	Orthopaedics and Traumatology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Abstract:

To study the effect of different approach and dosage of bisphosphonate on bone loss in previous established rabbit osteolysis model after hip joint replacement.

List of Research Outputs

Cheng S.C. and Chiu P.K.Y., Proprioceptive performance and quality of life meausrement in patients with total knee arthroplasty, unicondylar knee arthroplasty, knee osteoarthritis, and normal individuals, The 25th Annual Congress of Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2005, 9: S60.

Chiu P.K.Y., 1. Revision surgery for wear and osteolysis after THA 2. Computer assisted TKA, 2006 National Symposium in Joint Reconstructive Surgery and Seventh South China Advanced Course in New Techniques of Joint Surgery, organized by the Joint Section of Chinese Orthopaedic Association and the Joint Section of Guangdong Province Orthopaedic Association, June 21-25, 2006 at Guangzhou, China. 2006.

Chiu P.K.Y., 1. Soft tissue releases in TKA 2. Revision TKA, Seventh International Spine-Joint-Trauma Symposium organized by Peking Union Medical College Hospital, October 15-18, 2005 at Beijing, China. 2005.

Chiu P.K.Y., 1. TKA - how I do it 2. Computer assisted TKA, Symposium in Total Knee Replacement Surgery, organized by People's Hospital of Xinjiang Uygur Autunomous Region, June 21-25, 2006 at Urumqi, Xinjiang, China. 2006.

Chiu P.K.Y., Chiu K.H., Griffith J.F. and Leong L.L.Y., Post-SARS avascular necrosis, Hospital Authority, HKSAR: "Challenges of Severe Acute Respiratory Syndrome". Elsevier Science, 2006, 548-558.

Chow S.P., Lam K.W., Gibson I., Ngan A.H.W., Lu W.W., Ip W.Y. and Chiu P.K.Y., A novel artificial prosthetic replacement for the proximal interphalangeal joint of the hand - From concept to prototype, Hand Surgery. 2005, 10(2&3): 159-168.

Kuong E., Ng T.P., Wong H.M., Chiu P.K.Y., Tang W.M. and Yau P.W.P., Radiographic and clinical measurement of knee flexion after total knee arthroplasty and the weight of weight-bearing , The 25th Annual Congress of Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2005, 9: S18.

Lie W.H., Yau P.W.P., Wong S., Wong L., Chiu P.K.Y. and Tang W.M., Inter- and Intra-observer errors in measuring transepicondylar axis of distal femur using computerized tomogram, The 25th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2005, 9: S16.

Liu K., Chiu P.K.Y., Zhang S., Tang W.M., Ng T.P. and Yau P.W.P., Combined linked-unlinked total elbow arthroplasty: short-term results of 11 elbows, The 25th Annual Congress of Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2005, 9: S57.

Ng T.P., Zhu Y. and Chiu P.K.Y., Cementless acetabular component inserted without screws: the effect of immediate weight-bearing, The 25th Annual Congress of Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2005, 9: S56.

Ni G., Chiu P.K.Y., Lu W.W., 徐兵., Li Z. and Luk K.D.K., Effect of weight-bearing on micromechanics and chemical components of the interface between bioactive bone cement and bone , Chinese Journal of Orthopaedic Trauma. 2006, 8: 143-147.

Ni G., Lu W.W., Xu B., Chiu P.K.Y., Yang C., Li Z.Y., Lam W.M., Luk K.D.K. and Lam W.M., Infacial behaviour of strontium-containing hydroxyapatite cement with cancellous and cortical bone, Biomaterials. 2006, 27: 5127-5133.

Ni G., Lu W.W., Tang B., Ngan A.H.W., Chiu P.K.Y., Cheung K.M.C., Li Z. and Luk K.D.K., Mechanical properties of interfaces between bone and strontium-containing hydroxyapatite bone cement under non- and weight-bearing conditions by nanoindentation, 52nd Annual Meeting of Orthopaedic Research Society, Chicago, Illinois, March 19-22, 2006.

Ni G., Lu W.W., Chiu P.K.Y., 王岩., 張永.剛., 郝立.波., Li Z., 盧世.壁. and Luk K.D.K., 活性骨水泥用于髖關節置換翻修的生物力學及組織學評價, Orthopaedic Journal of China. 2006, 14: 177.

Ni G., Lu W.W., Chiu P.K.Y., Li Z., Fong D.Y.T. and Luk K.D.K., Strontium-containing hydroxyapatite (Sr-HA) bioactive cement for primary hip replacement: An in vivo study, J Biomed Mater Res Part B: Appl Biomater. 2006, 77B: 409-415.

Ni G., Lu W.W., Tang B., Ngan A.H.K., Chiu P.K.Y., Li Z. and Luk K.D.K., What is the effect of weight-bearing on interface between bone cement and bone?, The 25th Annual Congress of Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2005, 9: S28.

Ni G.X., Choy Y.S., Lu W.W., Chiu P.K.Y., Li Z.Y., Tang B. and Luk K.D.K., Nano-mechanics of bone and bioactive bone cement interfaces in a load-bearing model, Biomaterials. 2006, 27(9): 1963-1970.

Tang W.M. and Chiu P.K.Y., Assessment of pelvic rotation: A comparison of 3 methods , The 25th Annual Congress of Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2005, 9: S55.

Tang W.M. and Chiu P.K.Y., Avascular necrosis of femoral head: a short review, Hong Kong Bulletin on Rheumatic Diseases. 2005, 5: 49-51.

Yau P.W.P., Leung A., Liu K.G., Wong L.L.S. and Chiu P.K.Y., Can minimal incision approach be combined with computer assisted navigation total knee replacement? A cadaveric study on the errors in obtaining visually selected anatomical landmarks during registration process, The 6th Annual Meeting of CAOS-International Proceedings. 2006, 586-589.

Yau P.W.P., Leung A., Liu K.G., Yan C.H., Wong L.L.S. and Chiu P.K.Y., Errors in obtaining visually selected anatomic landmarks during registration process in non-image based navigation assisted total knee replacement - comparison between minimal incision approach and conventional incision approach, The 3rd Annual Meeting of the Asian Society for Computer Assisted Orthopaedic Surgery. 2006, 40.

Yau P.W.P., Yan C.H., Wong L.S., Leung A., Chiu P.K.Y. and Tang W.M., Errors in obtaining visually selected anatomical landmarks during registration process in non-image-based navigation-assisted total knee replacement: comparison between minimal incision approach and conventional incision approach, The 25th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2005, 9: S17.

Yau P.W.P., Chiu P.K.Y., Ng T.P. and Tang W.M., Incidence and severity of femoral and tibial bowing among Chinese patients: how it effects preoperative planning in total knee replacement, The 25th Annual Congress of Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2005, 9: S60.

Yau P.W.P., Leung A., Chiu P.K.Y., Tang W.M. and Ng T.P., Intra-observer errors in obtaining visually selected anatomic landmarks during registration process in non-image based navigation assisted TKR - A cadaveric experiment, The MIS Meets CAOS Symposium and Instructional Academy. Less and minimally invasive surgery for joint arthroplasty: Fact and fiction. 2005, 253-262.

Yau P.W.P., Leung A., Chiu P.K.Y., Tang W.M. and Ng T.P., Intra-observer errors in registration process in non-image based navigation assisted total knee replacement, J Bone Joint Surg Br Orthopaedic Proceedings. 2006, 88-B: 313.

Yau P.W.P., Leung A., Chiu P.K.Y., Tang W.M. and Ng T.P., Intra-observer errors in registration process in non-image based navigation, The 54th Annual Congress of the New Zealand Orthopaedic Association Annual Scientific Meeting. 2005, 15:52.

Yau P.W.P., Leung A., Chiu P.K.Y., Tang W.M. and Ng T.P., Intraobserver errors in obtaining visually selected anatomic landmarks during registration process in nonimage-based navigation-assisted total knee arthroplasty: a cadaveric experiment, Journal of Arthroplasty. 2005, 20(5): 591-601.

Yau P.W.P., Chiu P.K.Y., Tang W.M. and Tang W.M., Residual posterior femoral condyle osteophyte affects the flexion range after total knee replacement, International Orthopaedics (SICOT). 2005, 29: 375-379.

Zhang S.D., Tan J.W., Chiu P.K.Y. and Ng T.P., Comparison of the fatigue properties of bone cement specimens prepared with different monomer storing temperature and different polymerization ambient temperatures, 不同溫度保存單體在不同環境溫度下聚合的骨水泥抗疲勞性能比較, Chinese Journal of Orthopaedics. 2005, 25: 692-695.

Researcher : Chooi YS

List of Research Outputs

Cheung K.M.C. and Chooi Y.S., Hip adduction differences in adolescent idiopathic scoliosis: a cause or effect of scoliosis?, 25th Annual Congress of the Hong Kong Orthopaedic Association, Nov 19-20 2005, Hong Kong. 2005.

Researcher : Chow SP

Project Title:	Plate fixation develop and biomechanical evaluation for Type C2 and C3 Fractures of Distal Radius: a collaborative study with AO Mathys Medical Ltd and Nanfang Hospital, Guangzhou, PRC
Investigator(s):	Chow SP, Lu WW, Pei G.X., Zhu L.J., Leung F.
Department:	Orthopaedics and Traumatology
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	07/2004
Completion Date:	09/2005

Abstract:

To design and biomechanically evaluate a novel locking plates with proper surgical procedure; to compare the effectiveness of the fragment-specific fixation using current plates applied in an AO type C2 and C3 distal radius fracture model; to provide evidence based results from research for successfully apply this invention in clinical trial of human subject in hospitals in PRC.

Project Title:	Novel prosthetic replacements for metacarpophalangeal (MCP) joints
Investigator(s):	Chow SP
Department:	Orthopaedics and Traumatology
Source(s) of Funding:	Merit Award for RGC CERG Funded Projects
Start Date:	01/2005

Abstract:

N/A

Project Title:	Novel prosthetic replacements for metacarpophalangeal (MCP) joints
Investigator(s):	Chow SP, Ngan AHW, Chiu PKY, Ip WY, Gibson I, Lu WW
Department:	Orthopaedics and Traumatology
Source(s) of Funding:	Competitive Earmarked Research Grants (CERG)
Start Date:	01/2005

Abstract:

To reproduce the anatomical shape in order to achieve a good range of movement and to interact with the soft tissue in achieving the necessary stability; to have the right material for both the surface and the stem of the implant.

Project Title:	An animal model for vascularised nerve graft in complete spinal cord transection
Investigator(s):	Chow SP, Ip WY, Fung B
Department:	Orthopaedics and Traumatology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2006

Abstract:

Objectives :To establish an aminal model where a vascularised nerve graft can be used to bridge a complete transection of the spinal cord.Key issues and problem being addressed :In the past 20 years or so, attempts to achieve regeneration of the spinal cord across a defect left after spinal cord injury were directed towards three aspects :-a. To promote regeneration of the nerves by various active substances such as growth factorsb. To neutralise the inhibitors of regenerationc. To bridge the gap with all kinds of conduits and cells.The use of the peripheral nerve graft, which is highly successful in the peripheral nervous system, may be able to help bridge the gap, provide growth factors, or even neutralize the inhibitors. Indeed, Cajal, Kao, Wardrope, Cheng had all tried to use peripheral nerve grafts in different ways, yet only with rather feeble regeneration. One of the reasons for their failure, perhaps, was the lack of a good blood supply of the transplanted nerve graft in the environment of the spinal canal where the bony and ligamentous surrounding and the CSF were not conducive to re-vascularisation, thus leading to necrosis and fibrosis of the grafts. The use of vascularise nerve grafts (VNG) may therefore open up a new approach in spinal cord regeneration.The principal investigator had explored the use of VNG in spinal cord injury in the rat. A graft of the median and ulnar nerve of the upper limb was harvested with a long pedicle of blood vessl and was directed towards a defect of the spinal cord at the cervico-dorsal junction. Initially, a total transection of the cord was created, but all the animals died. Even with a hemi-transection model, 50% of the animal died unless very careful post-operative care was instituted. The subsequent study of the regeneration through the graft had to be carried out with the remaining intact half completely divided in order to show neurotransport and electrical conduction across the grafts. Extremely painstaking care and highly demanding technique was required. With such an amimal model, it was possible to show extraordinary good regeneration into the graft when compared to non-vascularised free nerve grafts (FNG).This animal model with a hemi-resection of the spinal cord, however, is open to all kinds of criticism. It will be ideal to develop an animal model where a VNG can be used to bridge a complete transection of the spinal cord.In trying to establish a VNG for a complete transection of the spinal cord, it is almost certain that the only feasible site for a complete cord transection in the animal has to be performed below the mid-thoracic level as a higher level will incur an extremely high mortality rate. In this area, vascularised nerve grafting post 2 major problems :-(1) Initial exploration showed that pedicled nerve graft from both the upper limb and the lower limb could not reach this area in the rat and rabbit.(2) If free vascularised grafts are used, the recipient blood vessels are too small for microvascular anatomosis even in the rat.

List of Research Outputs

Chow S.P., Lam K.W., Gibson I., Ngan A.H.W., Lu W.W., Ip W.Y. and Chiu P.K.Y., A novel artificial prosthetic replacement for the proximal interphalangeal joint of the hand - From concept to prototype, Hand Surgery. 2005, 10(2&3): 159-168.

Chow S.P., Different fixation devices for distal radius fractures, 2nd International Symposium on Hand Surgery and the Advances in Hand Therapy, Jakarta, Indonesia, 12-14 August 2005.

Chow S.P., Distal radius fractures: Management options and choice of plating techniques, Invited Teaching Fellow to the University of Malaya, Kuala Lumpur, Malaysia, 12-19 February 2006. 2006.

Chow S.P., Flexor tendon healing: Challenges and rehabilitation, Invited Teaching Fellow to the University of Malaya, Kuala Lumpur, Malaysia, 12-19 February 2006. 2006.

Chow S.P., Lessons learnt from the development of an artificial finger joint, Biomedical Engineering Workshop, Hong Kong, 28-29 April 2006.

Chow S.P., Malalignment patterns after fracture of the distal radius, SICOT XXIII World Congress, Istanbul, Turkey, 2-9 September 2005.

Chow S.P., Mycobacterial infection in the upper extremity, Invited Teaching Fellow to the University of Malaya, Kuala Lumpur, Malaysia, 12-19 February 2006. 2006.

Chow S.P., Open reduction and plate fixation - Techniques and problems, AOEA Hand Seminar, Manila, Philippines, 4-7May 2006.

Chow S.P., Phalangeal fractures: Kirschner wire or otherwise?, Invited Teaching Fellow to the University of Malaya, Kuala Lumpur, Malaysia, 12-19 February 2006. 2006.

Chow S.P., Replantation - Techniques and indications, 3rd AO Hand Course, Tokyo, Japan, 14-16 May 2006 . 2006.

Chow S.P., The art and science in hand surgery, 2nd International Symposium on Hand Surgery and the Advances in Hand Therapy, Jakarta, Indonesia, 12-14 August 2005.

Chow S.P., The mangled hand, Invited Teaching Fellow to the University of Malaya, Kuala Lumpur, Malaysia, 12-19 February 2006. 2006.

Gibson I., Cheung L.K., Chow S.P., Cheung W.L., Beh S.L., Savalani M.M. and Lee S.H., The Use Of Rapid Prototyping To Assist Medical Applications, Rapid Prototyping Journal. UK, Emerald Group Publishing Ltd., 2006, 12: 53-58.

Lie C., Leung K.L. and Chow S.P., Nicolau syndrome following intramuscular diclofenac administration: A case report, Journal of Orthopaedic Surgery. 2006, 14(1): 104-107.

Yan C.H., Lau T.W., Leung K.L. and Chow S.P., Volar locking plate fixation of distal radial fractures in the elderly, The 25th Hong Kong Orthopaedic Association Annual Congress, 19-20 November 2005, Hong Kong . 2005.

Researcher : Ho G

List of Research Outputs

Chan D., Ho G. and Cheung K.M.C., Stem cell therapy for intervertebral disc degeneration, The Croucher Foundation Advanced Study Institute on Stem Cell Research, Nov 14-15. 2005.

Chan D., Ho G., Leong V.Y.L. and Cheung K.M.C., The effect of severity of disc degeration on mesenchymal stem cell's ability to regenerate the intervertebral disc., European Cells and Material: ECM VI/SRN I Spinal Motion Segment: From basic science to clinical application. Davos, Switzerland, July 2005 . 2005.

Cheung K.M.C., Ho G., Leung V. and Chan D., The effect of severity of degeneration on intervertebral disc regeneration by autologous mesenchymal stem cells, The 6th Combined Congress of the Spine and Paediatric Orthopaedic Sections of APOA, Taipei, Taiwan. Nov 24-27 2005.

Cheung K.M.C., Ho G., Chan D. and Leong V.Y.L., regeneration of nucleus pulposus after disectomy by autologous mesenchymal stem cells: a rabbit model, European Cells and Material: ECM VI/SRN I Spinal Motion Segment: From basic science to clinical application. Davos, Switzerland, July 2005 . 2005.

Hui T.Y., Ho G., Cheung K.M.C., Chan D., Cheung W.L. and Chan B.P., Rabbit bone marrow derived mesenchymal stem cells induced collagen gel contraction-fabrication of tissue-like structures with different cell densities, Tissue Engineering. May Ann Liebut, Inc., 2005, 110.

Leung V.Y.L., Ho G., Chan D. and Cheung K.M.C., The effect of severity of degeneration on intervertebral disc regeneration by autologous mesenchymal stem cells, 25th Annual Congress of the Hong Kong Orthopaedic Association, Nov 19-20 2005, Hong Kong. 2005.

Leung Y.L., Ho G., Chan D. and Cheung K.M.C., The effect of severity of degeneration on intervertebral disc regeneration by use of mesenchymal stem cells, 52nd Annual Meeting of Orthopaedic Research Society, Chicago, Illinois, March 19-22, 2006.

Leung Y.L., Ho G., Cheung K.M.C. and Chan D., The effect of severity of degeneration on intervertebral disc regeneration by use of mesenchymal stem cells, European Cells & Materials Conference, Davos, Switzerland. 2005.

Researcher : Ho G

List of Research Outputs

Chan D., Ho G. and Cheung K.M.C., Stem cell therapy for intervertebral disc degeneration, The Croucher Foundation Advanced Study Institute on Stem Cell Research, Nov 14-15. 2005.

Researcher : Hu Y

Project Title:	New signal signal processing technique for intraoperative spinal cord monitoring
Investigator(s):	Hu Y, Luk KDK
Department:	Orthopaedics and Traumatology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004
Completion Date:	10/2005

Abstract:

To develop a new signal processing techniques to enhance SNR of EPs. The findings of this project can help to develop fast EP measurement techniques and auto-classification methods of EP monitoring.

Project Title:	A Sensor Array Approach to Spatial Presentation on Surface Electromyography of Intra-muscular Pain Behaviour
Investigator(s):	Hu Y, Luk KDK
Department:	Orthopaedics and Traumatology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2006

Abstract:

The objectives of this study are 1) to develop new methodology of myoelectric signal acquisition, decomposition and processing in sensor array sEMG for discovering and exploration of in-vivo functional physiology of muscle, 2) to characterise and compare the in-vivo motor unit firing behaviour and coordination processes corresponding to the actual pathophysiological status; and 3) to investigate the pain behaviour and electrophysiology of neuromuscular system in healthy, myopathic, spinal cord compression, and nerve root compression condition. Pain is the most common clinical symptom in various pathological conditions, which usually affects neuromuscular electrophysiological patterns. However, the pathomechanism of the effect of pain on neuromuscular activation potential distribution and their coordination behavior are still unclear. The key issus of this study is to find various myoelectrical activity patterns of the insulted muscle area, which will establish a reliable model to simulate the pain effcts on muscle activation and muscle contraction behaviour.

List of Research Outputs

Cao Y., Chen C. and Hu Y., Application of independent component analysis to ECG cancellation in surfaceelectromyography measurement., Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2005, 22: 686-9.

Hu Y., Lam S.C.B., Chang C., Chan F.H.Y., Lu W.W. and Luk K.D.K., Adaptive Signal Enhancement of Somatosensory Evoked Potential for Spinal Cord Compression Detection: An Experimental Study., Comput Biol Med.. 2005, 35: 814-28.

Lam W.K., Leong J.C.Y., Li Y.H., Hu Y. and Lu W.W., Biomechanical And Electromyographic Evaluation Of Ankle Foot Orthosis And Dynamic Ankle Foot Orthosis In Spastic Cerebral Palsy. (Top 25 Hotest Articles in Jan-Mar, 2005), Gait Posture. 2005, 22: 189-97.

Ng M.C., Wong K.K.K., Li G., Lai S., Yang E.S., Hu Y. and Luk K.D.K., Proton-density-weighted spinal fMRI with sensorimotor stimulation at 0.2 T, Neuroimage. 2006, 29: 995-999.

Ng M.C., Wu E.X., Lau H.F., Hu Y., Yang E.S. and Luk K.D.K., Detection of ipsilateral and contralateral activation components in unilateral fingers-tapping using spinal BOLD fMRI., Proc. 14th ISMRM; 2006. Seattle, U.S.A.

Ng M.C., Hu Y., Wu E.X., Yang E.S. and Luk K.D.K., Diffusion Tensor-Based Fiber Tracking in Cervical Spinal Cord with a 3T MRI., IEEE Southwest Symposium on Image Analysis and Interpretation; 2006. Denver, Colorado, USA,, 76 - 80.

Ng M.C., Wong K.K., Li G., Lai S., Yang E.S., Hu Y. and Luk K.D.K., Proton Density-weighted Spinal Fmri With Sensorimotor Stimulation At 0.2t. , Neuroimage (accepted On 3rd Aug 2005.).. 2005.

Qiu W., Chang C., Liu W.Q., Poon P.W., Hu Y., Lam F.K., Hamernik R.P., WEI G. and Chan F.H.Y., Real-time Data-reusing Adaptive Learning Of A Radial Basis Function Network For Tracking Evoked Potentials., IEEE Trans Biomed Eng. . 2006, 53: 226-37.

Researcher : Ip WY

Project Title:	Study on wrist problems
Investigator(s):	Ip WY, Chow SP
Department:	Orthopaedics and Traumatology
Source(s) of Funding:	Other Funding Scheme
Start Date:	01/1996

Abstract:

To study the clinical problems of chronic wrist pain. The individual specific clinical problems including sequalae of fracture distal radius, carpal instability, distal radio-ulnar joint problems, triangular fibrocartilage complex lesions and ulnar abatment syndromes would be studied in details. The objectives are to find the best treatment methods and to improve the functional results.

Project Title:	The study of work related hand injuries in Hong Kong
Investigator(s):	Ip WY, Chow SP, Wu W.C.
Department:	Orthopaedics and Traumatology
Source(s) of Funding:	Occupational Safety and Health Council - Research Grant Projects
Start Date:	01/1998

Abstract:

To study the epidemiology of severe hand injuries which are work related in Hong Kong Island; to suggest more accurate prognostic factors and more reasonable disability assessment system of hand injury; to give suggestions in industrial safety; to improve management of severe hand injuries; to minimise the social cost of severe hand injuries.

List of Research Outputs

Choi K.Y., Lam M. and Ip W.Y., Dorsal ulnar flap- the anatomy and clinical application, 25th Annual Congress of The Hong Kong Orthopaedic Association, Hong Kong, 19-20 November 2005 . 2005.

Chow S.P., Lam K.W., Gibson I., Ngan A.H.W., Lu W.W., Ip W.Y. and Chiu P.K.Y., A novel artificial prosthetic replacement for the proximal interphalangeal joint of the hand - From concept to prototype, Hand Surgery. 2005, 10(2&3): 159-168.

Hui L.F., Ip W.Y. and Fong D.Y.T., Linguistic Validation Of The Diabetric Foot Ucler Scale Short Form Into Hong Kong Chinese, Conference On Quality Of Life Research In Asia. Hong Kong, 2006, 62.

Ip W.Y., A novel prosthetic replacement for the PIP joint of the hand - From concept to prototype, Chinese Society for Surgery of the Hand 2006 Congress, June 22, 2006.

Ip W.Y., Acute dislocation of the elbow caused by a solitary osteochondroma of the priximal radius, In: Leung YF, Ip SP, Wong A, Ip WY, Arch Orthop Trauma Surg. 2006, 126(2): 131-3.

Ip W.Y., Basic flap surgery from principles to rehabilitation, Conjoint Scientific Meeting of HKSSH and AADO, Hong Kong, March 19, 2006.

Ip W.Y., Bone regeneration with resorbable polylactide membrane and sponge in an unstable fracture model in rabbit radius , Guangtung Province Society for Surgery of the Hand Congress, Guangzhou, China, 11 November 2005 . 2005.

Ip W.Y., Bone regeneration with resorbable polylactide membrane and sponge in an unstable fracture model in rabbit radius, Tissue Engineering Scientific Institute Annual Meeting, Shanghai, China, 25 October 2005.

Ip W.Y., Injuries of proximal interphalangeal joint of the hand, 10th Annual Congress of Pakistan Society for Surgery of the Hand, Karachi, Pakistan, 21-23 February 2006.

Ip W.Y., Reconstruction of upper limb paralytic conditions, 10th Annual Congress of Pakistan Society for Surgery of the Hand, Karachi, Pakistan, 21-23 February 2006.

Ip W.Y., Reconstructive surgery in wound coverage - points to ponder, Second Asian Pacific Conference on Diabetic Foot Problems, Kuala Lumpur, Malayisa, 15-17 December 2005.

Ip W.Y., Tendon transfer in tetraplegia, Hong Kong Society for Surgery of the Hand Annual Congress, Hong Kong, 25-26 March 2006.

Ip W.Y., Treatment targets - the patients and/or her feet , Second Asian Pacific Conference on Diabetic Foot Problems, Kuala Lumpur, Malaysia, 15-17 December 2005.

Leung Y.F., Ip S.P., Wong A. and Ip W.Y., Acute dislocation of the elbow caused by a solitary osteochondroma of the proximal radius, Arch Orthop Trauma Surgery. 2006, 126(2): 131-133.

Leung Y.F., Ip S.P., Wong A. and Ip W.Y., Transscahpoid transcapitate transtriquetral perilunate fracture-dislocation: a case report , Journal of Hand Surgery [Am]. 2006, 31(4): 608-610.

Yuen C.K. and Ip W.Y., Opportunities for the use of bio-corrodible alloys in tissue engineering, Tissue Engineering Scientific Institute Annual Meeting, Shanghai, China, 25 October 2005.

Zhou W.Y., Lee S.H., Cheung W.L., Wong M. and Ip W.Y., Elective laser sintering of porous scaffords from poly (L-lactide). Microsphers and its nanocompride with carbonated hydroxyapative nanosphers, European Society for Biomaterials 2006 Conference, Nantes, France, June 15, 2006.

Researcher : Lam KW

List of Research Outputs

Chow S.P., Lam K.W., Gibson I., Ngan A.H.W., Lu W.W., Ip W.Y. and Chiu P.K.Y., A novel artificial prosthetic replacement for the proximal interphalangeal joint of the hand - From concept to prototype, Hand Surgery. 2005, 10(2&3): 159-168.

Researcher : Lam SCB

List of Research Outputs

Hu Y., Lam S.C.B., Chang C., Chan F.H.Y., Lu W.W. and Luk K.D.K., Adaptive Signal Enhancement of Somatosensory Evoked Potential for Spinal Cord Compression Detection: An Experimental Study., Comput Biol Med.. 2005, 35: 814-28.

Researcher : Lam WK

List of Research Outputs

Lam W.K., Leong J.C.Y., Li Y.H., Hu Y. and Lu W.W., Biomechanical And Electromyographic Evaluation Of Ankle Foot Orthosis And Dynamic Ankle Foot Orthosis In Spastic Cerebral Palsy. (Top 25 Hotest Articles in Jan-Mar, 2005), Gait Posture. 2005, 22: 189-97.

Researcher : Lam WMR

List of Research Outputs

Li Z., Lu W.W., Ni G., Lam W.M.R., Chan D., Abbah S.A., Yang F., Cheung K.M.C. and Luk K.D.K., Strontium combined with calcium increases vertebral bone mineral density and stiffness in goats, 25th Annual Congress of the Hong Kong Orthopaedic Association, Nov 19-20 2005, Hong Kong. 2005.

Researcher : Lau TW

List of Research Outputs

Yan C.H., Lau T.W., Leung K.L. and Chow S.P., Volar locking plate fixation of distal radial fractures in the elderly, The 25th Hong Kong Orthopaedic Association Annual Congress, 19-20 November 2005, Hong Kong . 2005.

Researcher : Leong JCY

List of Research Outputs

Abbah S.A., Lu W.W., Luk K.D.K., Cheung K.M.C., Liu W., Chan D., Li Z. and Leong J.C.Y., New Bone Formation by Injected With Osteogenic Cells Confined in Sodium Alginate Microcapsules, The XXIII SICOT/SIROT Triennial World Congress held in Istanbul, Turkey, September 2-9, 2005.

Abbah S.A., Lu W.W., Cheung K.M.C., Zhao F., Chan D., Liu W.G., Li Z., Leong J.C.Y. and Luk K.D.K., Polymer encapsulated human osteoblastic cells form ectopic bone in mice, 52nd Annual Meeting of Orthopaedic Research Society, Chicago, Illinois, March 19-22, 2006.

Cheung K.M.C., Chen Y., Karppinen J., Chan D., Jim J.J.T., Luk K.D.K., Ala-Kokko L., Leong J.C.Y., Ott J., Sham P.C., Cheah K.S.E. and Song Y., Association of the Taq I allele in vitamin D receptor with degenerative disc disease and disc bulge in Chinese, Spine. 2006, 31(10): 1143-8.

Cheung K.M.C., Jim J.J.T., Noponen-Hietala N., Ott J., Karppinen J., Sahraravand A., Luk K.D.K., Yip S.P., Sham P.C., Song Y., Leong J.C.Y., Cheah K.S.E., Ala-Kokko L. and Chan D., The Genetics of intervertebral disc degenertation, European Cells and Material: ECM VI/SRN I Spinal Motion Segment: From basic science to clinical application. Davos, Switzerland, July . 2005.

Cheung K.M.C., Wang T., Carl A., Hu Y.G. and Leong J.C.Y., The effect of pinealectomy on scoliosis development in young non-human primates, SICOT 3rd Prize at the SICOT/SIROT 2005 XXIII World Congress, Istanbul, Turkey, September 2-9, 2005. 2005.

Cheung K.M.C., Wang T., Carl A., Hu Y.G. and Leong J.C.Y., The effect of pinealectomy on scoliosis development in young non-human primates, SICOT/SIROT 2005 XXIII World Congress, Istanbul, Turkey, September 2-9, 2005.

Cheung K.M.C., Wang T., Poon A.M.S., Carl A., Tranmer B., Hu Y.G., Luk K.D.K. and Leong J.C.Y., The effect of pinealectomy on scoliosis development in young non-human primates, Spine. 2005, 30(18): 2009-2013.

Cheung K.M.C., Lu W.W., Luk K.D.K., Wong C.T., Chan D., Shen J.X., Qiu G.X., Zheng Z.M., Li C.H., Liu S.L., Chan W.K. and Leong J.C.Y., Vertebroplasty by use of a strontium containing bioactive bone cement, Spine (Focus Issue). 2005, 30(17S): S84-S91.

Ho D.W.H., Cheung K.M.C., Chan D., Karppinen J., Yip S.P., Ott J., Luk K.D.K., Leong J.C.Y., Cheah K.S.E., Sham P.C. and Song Y., Linkage Analysis on familial Early-onset Degenerative Disc Disease(DDD), Hugo, HGM2006, 31 May - 3 June 2006 Helsinki, Finland.. 2006.

Jim J.J.T., Noponen-Hietala N., Cheung K.M.C., Ott J., Karppinen J., Sahraravand A., Luk K.D.K., Yip S.P., Sham P.C., Song Y., Leong J.C.Y., Cheah K.S.E., Ala-Kokko L. and Chan D., The TRP2 allele of COL9A2 is an age-dependent risk factor for the development and severity of intervertebral disc degeneration, Spine. 2005, 30: 2735-2742.

Lam W.K., Leong J.C.Y., Li Y.H., Hu Y. and Lu W.W., Biomechanical And Electromyographic Evaluation Of Ankle Foot Orthosis And Dynamic Ankle Foot Orthosis In Spastic Cerebral Palsy. (Top 25 Hotest Articles in Jan-Mar, 2005), Gait Posture. 2005, 22: 189-97.

Lu W.W., Abbah S.A., Cheung K.M.C., Chan D., Li Z.Y., Leong J.C.Y. and Luk K.D.K., Ectopic bone formation from Polymer-encapsulated osteogenic cells, 25th Annual Congress of the Hong Kong Orthopaedic Association, Nov 19-20 2005, Hong Kong. 2005.

Lu W.W., Wong C.T., Cheung K.M.C., Leong J.C.Y. and Luk K.D.K., In vitro mineralization of strontium-containing hydroxyapatite bioactive bone cement, SICOT/SIROT 2005 XXIII World Congress, Istanbul, Turkey, September 2-9, 2005.

Lu W.W., Ni G., Li Z., Tan B., Cheung K.M.C., Ngan A.H.W., Leong J.C.Y. and Luk K.D.K., Nanostructural and nanomechanics of the bone-cement interface in vivo, 25th Annual Congress of the Hong Kong Orthopaedic Association, Nov 19-20 2005, Hong Kong. 2005.

Song Y., Ho D.W.H., Cheung K.M.C., Karppinen J., YIP S. P., Leong J.C.Y., Ott J., Luk K.D.K., Cheah K.S.E., Sham P.C. and Chan D., Genetic Linkage analysis of early onset degenerative disc disease in Southern Chinese., HUGO Pacific meeting & Asia-pacific Human Genetics Conference (HUGO-AP 2006), March 6-10, 2006 Academica Sinica, Taipei. 2006.

Wang Y.J., Shi Q., Lu W.W., Cheung K.M.C., Aladin K.D.M., Li T.F., Dong Y.F., Zhou C.J., Zhou Q., Hu Z.J., Liu M., Bian Q., Li C.G., Luk K.D.K. and Leong J.C.Y., Cervical intervertebral disc degeneration induced by unbalanced dynamic and static forces: A novel in vivo rat model, Spine. 2006, 31(14): 1532-1538.

Wong W.N., Luk K.D.K., Leong J.C.Y., Wong S.F. and Wong K.K.Y., Continuous Dynamic Spinal Motion Analysis, Spine. 2006, 31(4): 414-419.

Yeung K.W.K., Cheung K.M.C., Lu W.W., Luk K.D.K. and Leong J.C.Y., A novel method for gradual scoliosis correction using the superelastic effect of nickel titanium alloys, SICOT/SIROT 2005 XXIII World Congress, Istanbul, Turkey, September 2-9, 2005.

Researcher : Leung HB

List of Research Outputs

Lee W.M., Leung H.B. and Wong J.W.C., Iatrogenic bilateral pneumothorax arising from acupuncture: a case report, Journal of Orthopaedic Surgery. 2005, 13(3): 300-302.

Researcher : Leung KL

List of Research Outputs

Leung K.L., Acetabular fractures: decision making and surgical indication, AO Pelvic Course for Surgeons, Chiangmai, Thailand, 25-29 May 2006.

Leung K.L., Acute infection after ORIF, AO Advanced Course for Surgeons, Chiangmai, Thailand, 25-29 May 2006.

Leung K.L., Acute infection after ORIF, AO Principles Course for Surgeons, Manila, Philippines, 2-4 March 2006.

Leung K.L., Acute infection, AO Masters Course for Surgeons, Chiangmai, Thailand, 25-29 May 2006.

Leung K.L., Bone healing: biology and response to implant insertion, AO Principles Course for Surgeons, Manila, Philippines, 2-4 March 2006.

Leung K.L., Bridge plate and MIPO technique, AO Principles Course for Surgeons, Manila, Philippines, 2-4 March 2006.

Leung K.L., Current concepts of distal radial fractures , Annual Congress, Royal College of Orthopaedic Surgeons of Thailand, Pattaya, Thailand, 19-21 October 2005.

Leung K.L., Development of minimally invasive surgery, Annual Congress, Royal College of Orthopaedic Surgeons of Thailand, Pattaya, Thailand, 19-21 October 2005 . 2005.

Leung K.L., Direct and indirect reduction techniques, AO Principles Course for Surgeons, Manila, Philippines, 2-4 March 2006.

Leung K.L., Distal radial fractures, AO Principles Course for Surgeons, Manila, Philippines, 2-4 March 2006.

Leung K.L., Distal radius fractures, AO Advanced Course for Surgeons, Chiangmai, Thailand, 25-29 May 2006 . 2006.

Leung K.L., Distal radius fractures, AO Advanced Course, Bali, Indonesia, 3-5 August 2005 . 2005.

Leung K.L., Distal radius fractures, AO Masters Course for Surgeons, Chiangmai, Thailand, 25-29 May 2006.

Leung K.L., Distal tibial percutaneous plating, Seminar on Minimally Invasive Surgery, Qingdao, China, 20-21 August 2005.

Leung K.L., Early complications of acetabular fractures, AO Pelvis and Acetabulum Course, Davos, Switzerland, 3-8 December 2005.

Leung K.L., Failed and neglected distal radius fractures, AO Masters Course for Surgeons, Chiangmai, Thailand, 25-29 May 2006 . 2006.

Leung K.L., Fractures easily missed, The Third Hong Kong International Orthopaedic Forum "Common Pitfalls in Orthopaedic Practice". Faculty of Medicine Building, The University of Hong Kong, 22-23 April 2006.

Leung K.L., Intraarticular proximal humeral fracture with valgus malalignment-11-C2, AO Manual of Fracture Management: Internal Fixators. Switzerland, Stuttgart, Thieme Verlag, 2006, 265-270.

Leung K.L., LISS - the other side of story, AO Seminar in "Complications of Fracture Management", Hong Kong, 25-26 February 2006.

Leung K.L., LISS - the other side of story, Recent Advances in Fracture Treatment, International Symposium, Kyungpook National University, Daegu, South Korea, 10 October 2005.

Leung K.L., Locking plate fixation of distal radial fractures , Korean Fracture Society Fall Meeting, Seoul, South Korea, 12 October 2006. 2005.

Leung K.L., MIPO of distal tibial fractures, Annual Congress, Royal College of Orthopaedic Surgeons of Thailand, Pattaya, Thailand, 19-21 October 2005 . 2005.

Leung K.L., MIPO of humerus - Is it really a good procedure?, Korean Fracture Society Fall Meeting, Seoul, South Korea, 12 October 2005.

Leung K.L., Minimally invasive techniques in proximal humeral fractures, AO Masters Course for Surgeons, Chiangmai, Thailand, 25-29 May 2006 . 2006.

Leung K.L., Orthopaedic surgeons in the front line management of disaster victims, 3rd Intercollegiate Scientific Meeting - "Disaster: How well prepared are we?", The Hong Kong Academy of Medicine, Hong Kong, 25 February 2006.

Leung K.L., Osteoporotic fractures and their management, Train the Trainer Workshop on Osteoporosis, The University of Hong Kong, Hong Kong, 15 October 2005 . 2005.

Leung K.L., Pelvic ring injuries in children and elderly, AO Pelvic & Acetabulum Course, Tokyo, Japan, 22-24 September 2005.

Leung K.L., Pitfalls in ankle fractures, AO Advanced Course for Surgeons, Chiangmai, Thailand, 25-29 May 2006.

Leung K.L., Principles and use of anti-rotation proximal femoral nailing and proximal tibial locking compression plating , Trauma Symposium, 25th Anniversary Meeting of Asean Orthopaedic Association, Manila, Philippines, 14 November 2005.

Leung K.L., Proximal tibia and tibial shaft MIPO, AO MIS Course for Surgeons, Chiangmai, Thailand, 25-29 May 2006.

Leung K.L., Spiral wedge tibial shaft fracture-42-B1 , AO Manual of Fracture Management: Internal Fixators. Switzerland, Stuttgart, Thieme-Verlag, 2006, 705-709.

Leung K.L., Surgery for distal radial fractues: for better form and function, The 31st Annual Meeting of the Japanese Society for Fracture Repair, Toyama, Japan, 8-9 July 2005.

Leung K.L., Treatment of distal femoral fractures in the elderly using a less-invasive plating technique, The 31st Annual Meeting of the Japanese Society for Fracture Repair, Toyama, Japan, 8-9 July 2005.

Lie C., Leung K.L. and Chow S.P., Nicolau syndrome following intramuscular diclofenac administration: A case report, Journal of Orthopaedic Surgery. 2006, 14(1): 104-107.

Yan C.H., Lau T.W., Leung K.L. and Chow S.P., Volar locking plate fixation of distal radial fractures in the elderly, The 25th Hong Kong Orthopaedic Association Annual Congress, 19-20 November 2005, Hong Kong . 2005.

Researcher : Leung YL

Project Title:	Molecular identity of nucleus pulposus cells in intervertebral disc
Investigator(s):	Leung YL, Cheung KMC, Chan D
Department:	Orthopaedics and Traumatology
Source(s) of Funding:	Small Project Funding
Start Date:	12/2005

Abstract:

1) Introduction: Low back pain has been a major focus in clinical practice. It represents a world-wide health problem of which about 70-80% population will experience low back pain in their lifetime [1,6]. Intervertebral disc degeneration has been suggested to associate with low back pain and sciatica and is thought to have multi-factorial causes. Previous study in human indicated that 90% of people will develop intervertebral disc degeneration above the age of 50. However, whether the degeneration is caused by natural aging or other unknown pathological conditions is still not clear [2]. Intervertebral discs (IVD) are avascular fibrocartilagenous structures between the vertebral bodies of the spine which function to articulate the spinal motion and are subject to high mechanical loading. Degeneration of IVD is generally characterized by changes in disc morphology, composition of extracellular matrix (ECM), loss of proteoglycan and water content, and an up-regulation of metalloproteinases in IVD [2,8-10]. Nonetheless, there is a lack of consensus on the cause of degeneration. In particular, whether the degeneration is a result from a loss of mechanical integrity in the disc or the mechanical loading itself being a precipitating factor of the degeneration is still controversial [6,7]. Studies have also suggested that the degeneration is related to a change of disc cells response to mechanical stimuli [11], but the molecular events happened during the response have not been clearly elaborated. IVD consists of three components: an outer fibrous ring (annulus fibrosus, AF), an inner gelatinous filling (nucleus pulposus, NP), and cartilaginous endplates (EP) which sandwich the former two structures. During organogenesis, NP is developed from the transformation of notochord and AF is differentiated from the condensation of sclerotome, implying that IVD is derived from mesodermal origin [3,4]. IVD is populated by three major cell types: chondrocytes in EP, notochordal/chondrocyte-like cells in NP and fibroblast-like cells in AF. NP and AF contain abundant ECM, particularly collagens and proteoglycans, which are present in different proportions in the two structures [6]. Cells in IVD have been defined base on their morphology, intercellular organization, and gene expression. NP is composed of a heterogeneous cell population of interconnected cells with prominent vacuoles, which are thought to be originated from the notochord, and small chondrocyte-like cells from yet unknown origin [12]. The notochordal cells appear to be replaced with chondrocyte-like cells during IVD maturation. The replacement of cells may be possibly due to apoptosis of notochordal cells together with an invasion of chondrocytes from AF or EP, or due to differentiation of notochordal cells into chondrocytic phenotype. Study has demonstrated that degeneration is not observed in IVD where notochordal cells persist to adult age, suggesting notochordal cells play vital role in maintaining IVD integrity [21]. Among various species studied, mature sheeps, dogs, and rats are suggested to retain NP cell populations mimicking those in adult humans [12]. In situ expression of variety of genes has been studies in NP. They express chondrocyte markers such as SOX9, collagen II and IX, agreccan, decorin, TGFbeta, and Ptc [13-18]. Gene knockout in mice has demonstrated that Sox5 and Sox6 regulate NP formation while Col2a1, Pax1/Pax9, Bapx1, and Jun play regulatory roles in the development of vertebral column [4,5,19,20]. To-date, the developmental regulation and specific function of NP in IVD are still largely unknown. In particular, there have been no genes found to be specifically expressed in the notochordal cells which can define their identity and distinguish them from chondrocyte-like cells in NP. 2) Key issues and problems: There has been limited advancement in the molecular biology of prenatal and postnatal IVD. Insufficient molecular characterization of IVD cells in is one of the major obstacles in understanding the properties of IVD and the etiology of disc degeneration. The lack of knowledge in NP cell-specific genes inevitably hampers the dissection of molecular pathways related to the IVD formation, maintenance, and the cause of IVD degeneration. On the other hand, we and other groups have been working on biological therapies such as the use of bioactive molecules and stem cells to regenerate disc cells in degenerated IVD. Without sufficient knowledge in the molecular signatures of the cells, accessing the outcome of the therapies will be difficult because cell phenotype in the treated IVD cannot be adequately described. In addition, the lack of cell-specific markers also compromises the use of high-throughput screening technologies that may rely on molecular cues to report expression changes specific to IVD. Taken together, the issue is critical to both basic and applied IVD research. 3) Hypothesis and objectives: It is hypothesized that notochordal cells in NP are specialized cells for IVD function and express unique genes which determine their specific differentiation status and cellular function. This study aims to identify the genes specifically expressed in notochordal cells in NP by the use of transcriptomics and bioinformatics.

List of Research Outputs

Leung Y.L., Chan D. and Cheung K.M.C., Regeneration of intervertebral disc by mesenchymal stem cells: Potentials, limitations, and future direction, Eur Spine J. 2006, 15 Suppl 15: 406-13.

Leung Y.L., Ho G., Chan D. and Cheung K.M.C., The effect of severity of degeneration on intervertebral disc regeneration by use of mesenchymal stem cells, 52nd Annual Meeting of Orthopaedic Research Society, Chicago, Illinois, March 19-22, 2006.

Leung Y.L., Ho G., Cheung K.M.C. and Chan D., The effect of severity of degeneration on intervertebral disc regeneration by use of mesenchymal stem cells, European Cells & Materials Conference, Davos, Switzerland. 2005.

Researcher : Li YH

List of Research Outputs

Lam W.K., Leong J.C.Y., Li Y.H., Hu Y. and Lu W.W., Biomechanical And Electromyographic Evaluation Of Ankle Foot Orthosis And Dynamic Ankle Foot Orthosis In Spastic Cerebral Palsy. (Top 25 Hotest Articles in Jan-Mar, 2005), Gait Posture. 2005, 22: 189-97.

Researcher : Li Z

List of Research Outputs

Abbah S.A., Lu W.W., Luk K.D.K., Cheung K.M.C., Liu W., Chan D., Li Z. and Leong J.C.Y., New Bone Formation by Injected With Osteogenic Cells Confined in Sodium Alginate Microcapsules, The XXIII SICOT/SIROT Triennial World Congress held in Istanbul, Turkey, September 2-9, 2005.

Abbah S.A., Lu W.W., Cheung K.M.C., Zhao F., Chan D., Liu W.G., Li Z., Leong J.C.Y. and Luk K.D.K., Polymer encapsulated human osteoblastic cells form ectopic bone in mice, 52nd Annual Meeting of Orthopaedic Research Society, Chicago, Illinois, March 19-22, 2006.

Li Z., Lu W.W., Ni G., Lam W.M.R., Chan D., Abbah S.A., Yang F., Cheung K.M.C. and Luk K.D.K., Strontium combined with calcium increases vertebral bone mineral density and stiffness in goats, 25th Annual Congress of the Hong Kong Orthopaedic Association, Nov 19-20 2005, Hong Kong. 2005.

Lu W.W., Ni G., Li Z., Tan B., Cheung K.M.C., Ngan A.H.W., Leong J.C.Y. and Luk K.D.K., Nanostructural and nanomechanics of the bone-cement interface in vivo, 25th Annual Congress of the Hong Kong Orthopaedic Association, Nov 19-20 2005, Hong Kong. 2005.

Ni G., Chiu P.K.Y., Lu W.W., 徐兵., Li Z. and Luk K.D.K., Effect of weight-bearing on micromechanics and chemical components of the interface between bioactive bone cement and bone , Chinese Journal of Orthopaedic Trauma. 2006, 8: 143-147.

Ni G., Lu W.W., Tang B., Ngan A.H.W., Chiu P.K.Y., Cheung K.M.C., Li Z. and Luk K.D.K., Mechanical properties of interfaces between bone and strontium-containing hydroxyapatite bone cement under non- and weight-bearing conditions by nanoindentation, 52nd Annual Meeting of Orthopaedic Research Society, Chicago, Illinois, March 19-22, 2006.

Ni G., Lu W.W., Chiu P.K.Y., 王岩., 張永.剛., 郝立.波., Li Z., 盧世.壁. and Luk K.D.K., 活性骨水泥用于髖關節置換翻修的生物力學及組織學評價, Orthopaedic Journal of China. 2006, 14: 177.

Ni G., Lu W.W., Chiu P.K.Y., Li Z., Fong D.Y.T. and Luk K.D.K., Strontium-containing hydroxyapatite (Sr-HA) bioactive cement for primary hip replacement: An in vivo study, J Biomed Mater Res Part B: Appl Biomater. 2006, 77B: 409-415.

Ni G., Lu W.W., Tang B., Ngan A.H.K., Chiu P.K.Y., Li Z. and Luk K.D.K., What is the effect of weight-bearing on interface between bone cement and bone?, The 25th Annual Congress of Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2005, 9: S28.

Researcher : Li Z

List of Research Outputs

Researcher : Liu K

List of Research Outputs

Liu K., Chiu P.K.Y., Zhang S., Tang W.M., Ng T.P. and Yau P.W.P., Combined linked-unlinked total elbow arthroplasty: short-term results of 11 elbows, The 25th Annual Congress of Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2005, 9: S57.

Researcher : Liu W

List of Research Outputs

Abbah S.A., Lu W.W., Luk K.D.K., Cheung K.M.C., Liu W., Chan D., Li Z. and Leong J.C.Y., New Bone Formation by Injected With Osteogenic Cells Confined in Sodium Alginate Microcapsules, The XXIII SICOT/SIROT Triennial World Congress held in Istanbul, Turkey, September 2-9, 2005.

Researcher : Lu D

List of Research Outputs

Cheung K.M.C., Lu D., Zhang H. and Luk K.D.K., In-vivo demonstration of the effectiveness of thoracoscopic anterior release using the fulcrum bending radiograph: a report of five cases, European Spine Journal. 2005, 21: 1-5.

Luk K.D.K., Ruan D.K., Lu D., Chow D.H.K. and Cheung K.M.C., Allogeneic intervertebral disc transplantation: Results of pre-clinical and clinical studies, European Cells and Materials. 2005, 10 (Supplement 3): 8.

Qiu G.U.I.X.I.N.G., Zhang J.I.A.N.G.U.O., Wang Y.I.P.E.N.G., Xu H.O.N.G.G.U.A.N.G., Zhang J.I.A., Weng X.I.S.H.E.N.G., Lin J.I.N., Zhao Y.U., Shen J.I.A.N.X.I.O.N.G., Yang X.I.N.Y.U., Luk K.D.K., Lu D. and Lu W.W., A New Operative Classification of Idiopathic Scoliosis: A Peking Union Medical College Method, Spine. 2005, 30(12): 1419-1426.

Researcher : Lu WW

Project Title:	Use of a new bioactive bone cement in the treatment of osteoporotic spinal fracture
Investigator(s):	Lu WW, Fong DYT, Cheung KMC, Ni G, Luk KDK, Liu S.L., Qiu G.X.
Department:	Orthopaedics and Traumatology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	10/2004

Abstract:

To help the poor and sick who suffer from osteoporotic spinal fractures; to apply for the market permit both in Hong Kong and China if this study can show the efficiency and safety in the clinical application.

Project Title:	Three-dimensional strontium-containing biomimetic scaffolds for bone tissue regeneration
Investigator(s):	Lu WW
Department:	Orthopaedics and Traumatology
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2005
Completion Date:	06/2006

Abstract:

N/A

List of Research Outputs

Abbah S.A., Lu W.W., Luk K.D.K., Cheung K.M.C., Liu W., Chan D., Li Z. and Leong J.C.Y., New Bone Formation by Injected With Osteogenic Cells Confined in Sodium Alginate Microcapsules, The XXIII SICOT/SIROT Triennial World Congress held in Istanbul, Turkey, September 2-9, 2005.

Abbah S.A., Lu W.W., Cheung K.M.C., Zhao F., Chan D., Liu W.G., Li Z., Leong J.C.Y. and Luk K.D.K., Polymer encapsulated human osteoblastic cells form ectopic bone in mice, 52nd Annual Meeting of Orthopaedic Research Society, Chicago, Illinois, March 19-22, 2006.

Abernethy A.B. and Lu W.W., Gait patterns, In: M. Akay (Ed.), Wiley Encyclopedia of Biomedical Engineering. Hoboken, NJ, Wiley, 2006.

Aladin K.D.M., Lu W.W., Cheung K.M.C., Yeung K.W.K. and Chan D., Impact of Trp2 allele mutation of alpha-2 chain in collagen IX on the structural integrity of human annulus fibrosus, European Cells and Materials Symposium: Spinal Motion Segment: From Basic Science to Clinical Application, 4th to 7th July, 2005. Davos, Switzerland. 2005.

Aladin Kaderbatcha D.M., Lu W.W., Cheung K.M.C., Yeung K.W.K. and Chan D., Impact of the Trp2 allele mutation of the alpha-2 chain in collagen IX on the structural integrity of human annulus fibrosus., European Cells and Material: ECM VI/SRN I Spinal Motion Segment: From basic science to clinical application. Davos, Switzerland, July 2005 . 2005.

Chan B.P., Hui T.Y., Chan C.M., So K.F., Lu W.W., Cheung K.M.C., Salomatina E. and Yaroslavsky A., Photochemical crosslinking for collagen-based scaffolds - A study on optical properties, mechanical properties, stablility and haematocompatibility, Tissue Engineering. USA, Mary Ann Liebert, Inc., 2006.

Chan Y.L., Wang M., Lu W.W. and Cheung K.M.C., An investigation into a surface-treated shape memory alloy for orthopaedic applications, Proceedings of the International Symposium on Quality of Bone and Scaffold Materials Evaluated by microCT, pQCT and MRI. Hong Kong, The Chinese University of Hong Kong, 2005, 163.

Cheung K.M.C., Yeung K.W.K., Chung J.C.Y. and Lu W.W., Device for correcting spinal deformities, Chinese Non-provisional Patent (No. 03824606.6). Filed: 16 November, 2005. 2005.

Cheung K.M.C., Yeung K.W.K., Lu W.W. and Luk K.D.K., Gradual deformity correction by use of the super elastic property of nickel-titanium alloy: in-vivo demonstration in a goat model, 40th Annual Meeting of Scoliosis Research Society, Miami, Florida, USA, October 27-30, 2005.

Cheung K.M.C., Yeung K.W.K., Lu W.W. and Luk K.D.K., Prediction of spinal flexibility in adolescent idiopathic scoliosis: a quantitative analysis by in-vivo correction force measurements, SICOT/SIROT 2005 XXIII World Congress, Istanbul, Turkey, September 2-9, 2005.

Cheung K.M.C., Yeung K.W.K., Chung J.C.Y. and Lu W.W., Shape memory material and method of making the same (Heat treatment protocol), Japan Non-provisional Patent (No. 100064746). Filed 19 April 2004. Publication date: 14 October 2005 . 2005.

Cheung K.M.C., Lu W.W., Luk K.D.K., Wong C.T., Chan D., Shen J.X., Qiu G.X., Zheng Z.M., Li C.H., Liu S.L., Chan W.K. and Leong J.C.Y., Vertebroplasty by use of a strontium containing bioactive bone cement, Spine (Focus Issue). 2005, 30(17S): S84-S91.

Chow S.P., Lam K.W., Gibson I., Ngan A.H.W., Lu W.W., Ip W.Y. and Chiu P.K.Y., A novel artificial prosthetic replacement for the proximal interphalangeal joint of the hand - From concept to prototype, Hand Surgery. 2005, 10(2&3): 159-168.

Ho J.P.Y., Wu S.L., Poon R.W.Y., Chung C.Y., Tjong S.C., Chu P.K., Yeung K.W.K., Lu W.W., Cheung K.M.C. and Luk K.D.K., Oxygen plasma treatment to restrain nickel out diffusion from porous nickel titanium orthopedic materials, 5th Asian-European International Conference on Plasma Surface Engineering, Qingdao, China, September 12-16, 2005.

Hu Y., Lam S.C.B., Chang C., Chan F.H.Y., Lu W.W. and Luk K.D.K., Adaptive Signal Enhancement of Somatosensory Evoked Potential for Spinal Cord Compression Detection: An Experimental Study., Comput Biol Med.. 2005, 35: 814-28.

Lam W.K., Leong J.C.Y., Li Y.H., Hu Y. and Lu W.W., Biomechanical And Electromyographic Evaluation Of Ankle Foot Orthosis And Dynamic Ankle Foot Orthosis In Spastic Cerebral Palsy. (Top 25 Hotest Articles in Jan-Mar, 2005), Gait Posture. 2005, 22: 189-97.

Li Z., Lu W.W., Ni G., Lam W.M.R., Chan D., Abbah S.A., Yang F., Cheung K.M.C. and Luk K.D.K., Strontium combined with calcium increases vertebral bone mineral density and stiffness in goats, 25th Annual Congress of the Hong Kong Orthopaedic Association, Nov 19-20 2005, Hong Kong. 2005.

Liu W.G., Lu W.W. and Yao K.D., Chitosan-based Nonviral Vectors For Gene Delivery, Handbook Of Carbohydrate Engineering. NY, Taylor & Francis Group, 2005, 1.

Lu W.W., Biomechanics, As Reviewer. 2005.

Lu W.W., Chinese Journal of Orthopaedic Trauma. 2005.

Lu W.W., Abbah S.A., Cheung K.M.C., Chan D., Li Z.Y., Leong J.C.Y. and Luk K.D.K., Ectopic bone formation from Polymer-encapsulated osteogenic cells, 25th Annual Congress of the Hong Kong Orthopaedic Association, Nov 19-20 2005, Hong Kong. 2005.

Lu W.W., Wong C.T., Cheung K.M.C., Leong J.C.Y. and Luk K.D.K., In vitro mineralization of strontium-containing hydroxyapatite bioactive bone cement, SICOT/SIROT 2005 XXIII World Congress, Istanbul, Turkey, September 2-9, 2005.

Lu W.W., Ni G., Li Z., Tan B., Cheung K.M.C., Ngan A.H.W., Leong J.C.Y. and Luk K.D.K., Nanostructural and nanomechanics of the bone-cement interface in vivo, 25th Annual Congress of the Hong Kong Orthopaedic Association, Nov 19-20 2005, Hong Kong. 2005.

Luk K.D.K., Chen L. and Lu W.W., A stronger bicortical sacral pedicle screw fixation through the S1 endplate: an in-vitro cyclic loading and pull-out force evaluation, Spine. 2005, 30: 525-529.

Ni G., Chiu P.K.Y., Lu W.W., 徐兵., Li Z. and Luk K.D.K., Effect of weight-bearing on micromechanics and chemical components of the interface between bioactive bone cement and bone , Chinese Journal of Orthopaedic Trauma. 2006, 8: 143-147.

Ni G., Lu W.W., Xu B., Chiu P.K.Y., Yang C., Li Z.Y., Lam W.M., Luk K.D.K. and Lam W.M., Infacial behaviour of strontium-containing hydroxyapatite cement with cancellous and cortical bone, Biomaterials. 2006, 27: 5127-5133.

Ni G., Lu W.W., Tang B., Ngan A.H.W., Chiu P.K.Y., Cheung K.M.C., Li Z. and Luk K.D.K., Mechanical properties of interfaces between bone and strontium-containing hydroxyapatite bone cement under non- and weight-bearing conditions by nanoindentation, 52nd Annual Meeting of Orthopaedic Research Society, Chicago, Illinois, March 19-22, 2006.

Ni G., Lu W.W., Chiu P.K.Y., 王岩., 張永.剛., 郝立.波., Li Z., 盧世.壁. and Luk K.D.K., 活性骨水泥用于髖關節置換翻修的生物力學及組織學評價, Orthopaedic Journal of China. 2006, 14: 177.

Ni G., Lu W.W., Chiu P.K.Y., Li Z., Fong D.Y.T. and Luk K.D.K., Strontium-containing hydroxyapatite (Sr-HA) bioactive cement for primary hip replacement: An in vivo study, J Biomed Mater Res Part B: Appl Biomater. 2006, 77B: 409-415.

Ni G., Lu W.W., Tang B., Ngan A.H.K., Chiu P.K.Y., Li Z. and Luk K.D.K., What is the effect of weight-bearing on interface between bone cement and bone?, The 25th Annual Congress of Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2005, 9: S28.

Ni G.X., Choy Y.S., Lu W.W., Chiu P.K.Y., Li Z.Y., Tang B. and Luk K.D.K., Nano-mechanics of bone and bioactive bone cement interfaces in a load-bearing model, Biomaterials. 2006, 27(9): 1963-1970.

Poon R.W., Ho J.P., Liu X.Y., Chung C.Y., Chu P.K., Yeung K.W.K., Lu W.W. and Cheung K.M.C., Formation of Titanium Nitride barrier layer in Nickel-Titanium shape memory alloys by nitrogen plasma immersion ion implantation for better corrosion resistance, Thin Solid Films. 2005, 488: 20-25.

Poon R.W., Ho J.P., Luk C.M., Liu X.Y., Chung C.Y., Chu P.K., Yeung K.W.K., Lu W.W. and Cheung K.M.C., Improvement of Corrosion Resistance of NiTi Orthopedic Materials by Carbon Plasma Immersion Ion Implantation, Nuclear Instruments and Methods in Physics Research B. 2006, 242: 270-274.

Poon R.W.Y., Ho J.P.Y., Liu X.Y., Chung C.Y., Tjong P.K., Chu P.K., Yeung K.W.K., Lu W.W. and Cheung K.M.C., Improvement of surface properties of orthopedic nickel-titanium shape memory alloys by nitrogen plasma immersion ion implantation, 14th International Conference on Surface Modification of Materials by Ion Beams (SMMIB), September 4-9, 2005, Kusadasi, Turkey. 2005.

Poon R.W.Y., Ho J.P.Y., Liu X.Y., Chung C.Y., Chu P.K., Yeung K.W.K., Lu W.W. and Cheung K.M.C., Improvements of anti-corrosion and mechanical properties of NiTi orthopedic materials by acetylene, nitrogen and oxygen plasma immersion ion implantation, Nuclear Instruments and Methods in Physics Research B. 2005, 237: 411-416.

Qiu G.U.I.X.I.N.G., Zhang J.I.A.N.G.U.O., Wang Y.I.P.E.N.G., Xu H.O.N.G.G.U.A.N.G., Zhang J.I.A., Weng X.I.S.H.E.N.G., Lin J.I.N., Zhao Y.U., Shen J.I.A.N.X.I.O.N.G., Yang X.I.N.Y.U., Luk K.D.K., Lu D. and Lu W.W., A New Operative Classification of Idiopathic Scoliosis: A Peking Union Medical College Method, Spine. 2005, 30(12): 1419-1426.

Tong H.W., Wang M. and Lu W.W., Mechanical evaluation of pedical screws and rods made of a shape memory alloy, Proceedings of the International Symposium on Quality of Bone and Scaffold Materials Evaluated by microCT, pQCT and MRI. Hong Kong, The Chinese University of Hong Kong, 2005, 167.

Wang X.T., Choi Y.K., Lu W.W. and Wang W.P., Rod-like trabeculae extraction from cancellous bone microstructure using topological analysis, Ninth International Conference on Computer Aided Design and Computer Graphics (CADCG 2005). IEEE Computer Society, 2005, 173-180.

Wang Y.J., Shi Q., Lu W.W., Cheung K.M.C., Aladin K.D.M., Li T.F., Dong Y.F., Zhou C.J., Zhou Q., Hu Z.J., Liu M., Bian Q., Li C.G., Luk K.D.K. and Leong J.C.Y., Cervical intervertebral disc degeneration induced by unbalanced dynamic and static forces: A novel in vivo rat model, Spine. 2006, 31(14): 1532-1538.

Wu S.L., Liu X.M., Chung C.Y., Yeung K.W.K., Chu P.K., Chu C.L., Lu W.W. and Cheung K.M.C., Nickel relaese behavior and biocompatibility of oxidized porous NiTi, European Materials Research Society 2006 Spring Meeting, Nice, France, May 29 to June 2, 2006.

Wu S.L., Chu P.K., Liu X.M., Chung C.Y., Ho J.P., Chu C.L., Yeung K.W.K., Lu W.W., Luk K.D.K. and Cheung K.M.C., Surface Characteristics, Mechanical Properties, and Cytocompatibility of Oxygen Plasma-Implanted Porous Nickel Titanium Shape Memory Alloy, Journal of Biomedical Materials Research: Part A. 2006, 79A: 139-146.

Yeung K.W.K., Lu W.W., Luk K.D.K. and Cheung K.M.C., A Novel design of spinal implant coupling by the use of shape memory effect of nickel titanium alloys, SICOT/SIROT 2005 XXIII World Congress, Istanbul, Turkey, September 2-9, 2005.

Yeung K.W.K., Lu W.W., Luk K.D.K. and Cheung K.M.C., A novel "smart" spinal implant locking mechanism based on nickel-titanium alloy, 40th Annual Meeting of Scoliosis Research Society, Miami, Florida, USA, October 27-30, 2005.

Yeung K.W.K., Cheung K.M.C., Lu W.W., Luk K.D.K. and Leong J.C.Y., A novel method for gradual scoliosis correction using the superelastic effect of nickel titanium alloys, SICOT/SIROT 2005 XXIII World Congress, Istanbul, Turkey, September 2-9, 2005.

Yeung K.W.K., Lu W.W., Luk K.D.K. and Cheung K.M.C., A smart locking mechanism for orthopaedic implants, 52nd Annual Meeting of Orthopaedic Research Society, Chicago, Illinois, March 19-22, 2006.

Yeung K.W.K., Lu W.W., Luk K.D.K. and Cheung K.M.C., A “Smart” Locking Mechanism For All Orthopaedic Implants, 25th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 19-20, 2005.

Yeung K.W.K., Poon R.W., Liu X.Y., Ho J.P., Chung C.Y., Chu P.K., Lu W.W., Chan D. and Cheung K.M.C., Corrosion resistance, mechanical properties and cyto-compatibility of NiTi shape memory alloys using nitrogen, and oxygen plasma immersion ion implantation, Journal of Biomedical Materials Research: Part A. 2005, 75: 256-67.

Yeung K.W.K., Poon R.W.Y., Liu X.Y., Ho J.P.Y., Chung C.Y., Chu P.Y., Lu W.W., Chan D. and Cheung K.M.C., Enhanced corrosion resistance and biocompatibility by plasma implantation of nickel-titanium alloys: An in-vitro and surface chemical study, 51st Annual Meeting of Orthopaedic Research Society, Washington DC, U.S.A., 2005.

Yeung K.W.K., Poon R.W.Y., Liu X., Ho J.P.Y., Chung C.Y., Chu P.K., Lu W.W., Chan D. and Cheung K.M.C., Nickel suppression in Ni-Ti alloys by plasma immersion ion implantation surface treatment: new materials for orthopaedic implantation, European Cells and Materials. 2005, 10(3): 78.

Yeung K.W.K., Poon R.W., Liu X.Y., Chung C.Y., Chu P.K., Lu W.W., Chan D. and Cheung K.M.C., Nitrogen Plasma Immersion Ion Implanted Nickel Titanium Alloys For Orthopedic Use, 5th Asian-European International Conference on Plasma Surface Engineering, Qingdao, China, Sept 12-16, 2005.. 2005.

Yeung K.W.K., Poon R.W.Y., Liu X.Y., Chung C.Y., Chu P.K., Lu W.W., Chan D. and Cheung K.M.C., Nitrogen plasma immersion ion implanted nickel titanium alloys for orthopedic use, 5th Asian-European International Conference on Plasma Surface Engineering, Qingdao, PR China, September 12-16. 2005.

Yeung K.W.K., Lu W.W., Luk K.D.K. and Cheung K.M.C., Progressive deformity correction using the superelastic property of nickel-titanium alloy: in-vivo demonstration in a goat model, 52nd Annual Meeting of Orthopaedic Research Society, Chicago, Illinois, March 19-22, 2006.

Yeung K.W.K., Chan Y.L., Chan S.C.W., Liu X.Y., Chung C.Y., Chu P.K., Lu W.W., Luk K.D.K., Chan D. and Cheung K.M.C., Suppression of nickel release in nickel-titanium alloys by plasma immersion ion implantation surface treatment: towards a new generation of "smart" orthopaedic implants, 33rd IEEE International Conference on Plasma Science, Traverse City, Michigan, U.S.A., June 4-8, 2006.

Yeung K.W.K., Chu P.K., Poon R.W.Y., Lu W.W. and Cheung K.M.C., Surface treated shape memory materials by the use of plasma immersion ion implantation and deposition or related ion-beam and plasma-based techniques for biomedical applications, US Non-Provisional Patent (No. 11/331264). Filed on January 11, 2006. 2006.

Zhao F., Ma T. and Lu W.W., Effects of Hydroxyapatite on Excellular Matrix Organization of Human Mesenchymal Stem Cell within 3-D Hydroxyapatite / chitosan-gelatin Constructs, Annual Meeting - Biomaterials: The Enabling Technology. Pittsburgh, Pennsylvania, USA, April 26-29, 2006.

Zhao F., Grayson W.L., Ma T., Bunnell B. and Lu W.W., Effects of hydroxyapatitie in 3-D chitosan-gelatin polymer network on human mesenchymal stem cell construct development, Biomaterials. 2006, 27: 1859-1867.

Researcher : Luk KDK

Project Title:	A minimal invasive approach to anterior release in scoliosis by chemonucleolysis: an experimental study with the rabbit scoliosis model
Investigator(s):	Luk KDK
Department:	Orthopaedics and Traumatology
Source(s) of Funding:	Outstanding RGC Projects
Start Date:	09/1998

Abstract:

To investigate whether the effect of chymopapain on generating spinal lateral instability can be used to treat scoliosis deformity; to develop a thoracoscopic-assisted or CT-guided chemonucleolysis technique to replace the conventional anterior spinal release method.

Project Title:	Provision of individualized biomechanical and electrophysiological service for occupational low back disorder patients
Investigator(s):	Luk KDK, Lu WW, Hu Y
Department:	Orthopaedics and Traumatology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	12/2003

Abstract:

To assess the low back muscular function and biomechanical problems of low back disorder patients to identify, evaluate and quantify potential of factors of OLBD; to study the drawbacks and benefits of conventional treatments; to introduce an individualized biomechanical and electrophysiological assessment service to identify specific OLBD problems in individual patients, and provide guidelines both for an optimal rehabilitation treatment and for a future workplace regimen to prevent recurrence.

Project Title:	MRI imaging analysis for severity and location of cervical spondylotic myelopathy
Investigator(s):	Luk KDK, Hu Y, Yang ES
Department:	Orthopaedics and Traumatology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	02/2004
Completion Date:	01/2006

Abstract:

To study the protocol of MRI examination based on the DWI and DTI technique for cervical spine diagnosis; to develop an image processing technique to measure the severity and location of spinal cord deficits in CSM; to trace the MRI signal changes along spinal cord and compare the difference between normal subjects and CSM patients.

Project Title:	Investigation on in-vivo Mechanical Properties of Degenerated Intervertebral Disc Using Magnetic Resonance Elastography
Investigator(s):	Luk KDK
Department:	Orthopaedics and Traumatology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2005

Abstract:

Intervertebral disc degeneration is frequently cited as a cause of low back pain as it would lead to changes in mechanical properties of the disc, causing instability of the spine. In most of the cases, “black disc” and “high intensity zone” in MRI are diagnostic signs of disc degeneration but there is no definite evidence that this is the gold standard for diagnosis of low back pain. With the development of the MRI techniques, Magnetic Resonance Elastography (MRE), it allows in-vivo measurement of the mechanical properties of different tissues. MRE is a phase-contrast-based technique that can directly visualize and quantitatively measure local values of shear modulus, elasticity and stiffness by propagating acoustic strain waves in tissue subjected to harmonic mechanical excitation[1, 2]. Since the discovery of MRE, studies have been performed in animal tissue[3, 4], human brain[5] and human skeletal muscle[6] to find the mechanical properties of different tissues. MRE has also been shown to be an effective diagnostic tool for breast cancer[7, 8]. However, this technique has not been developed in the intervertebral disc and its application on diagnosis of disc diseases has not yet been explored either. In the current study, we will apply MRE to disc. Objective This study will apply MRE to detect the mechanical property of spinal disc in normal subjects and patients with degenerative disc disease. Mechanical property change due to pathological condition will be characterized. References [1] R. Muthupillai, P. J. Rossman, D. J. Lomas, J. F. Greenleaf, S. J. Riederer & R. L. Ehman, Magnetic resonance imaging of transverse acoustic strain waves, Magn Reson Med 36(2), 1996, 266-274. [2] R. Muthupillai, D. J. Lomas, P. J. Rossman, J. F. Greenleaf, A. Manduca & R. L. Ehman, Magnetic resonance elastography by direct visualization of propagating acoustic strain waves, Science 269(5232), 1995, 1854-1857. [3] S. A. Kruse, J. A. Smith, A. J. Lawrence, M. A. Dresner, A. Manduca, J. F. Greenleaf & R. L. Ehman, Tissue characterization using magnetic resonance elastography: preliminary results, Phys. Med. Biol. 45, 2000, 1579-1590. [4] J. Bishop, G. Poole, M. Leitch & D. B. Plewes, Magnetic resonance imaging of shear wave propagation in excised tissue, J Magn Reson Imaging 8(6), 1998, 1257-1265. [5] S. A. Kruse, M. A. Dresner, P. J. Rossman, J. P. Felmlee, C. R. Jack & R. L. Ehman, 'Palpation of the brain' using magnetic resonance Ultraelastography. 7thISMRM, 1999, 258. [6] M. A. Dresner, G. H. Rose, P. J. Rossman, J. A. Smith, R. Muthupillai & R. L. Ehman, Functional MR elastography of human skeletal muscle. 6thISMRM, 1998, 463. [7] A. J. Lawrence, P. J. Rossman, J. L. Mahowald, A. Manduca, L. C. Hartmann & R. L. Ehman, Assessment of breast cancer by magneticresonance elastography. 7thISMRM, 1999, 525. [8] R. Sinkus, J. Lorenzen, D. Schrader, M. Lorenzen, M. Dargatz & D. Holz, High-resolution tensor MR elastography for breast tumour detection, Phys Med Biol 45(6), 2000, 1649-1664.

Project Title:	Proposal to develop the strategic research area on biomedical engineering
Investigator(s):	Luk KDK, Man RYK, Che CM, Cheung LK, Cheung PYS, Lu WW
Department:	Orthopaedics and Traumatology
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	05/2005

Abstract:

To improve quality of life through pioneering scientific discoveries and the education of future leaders in the medical and biotehnology fields. To establish an intra-institutional Biomedical Engineering research area with three sub-themes: Biomaterials and Tissue engineering; Electro-physioloyg/signal processing; Imaging/MRI. To foster interdisciplinary biomedical engineering by setting up a BME research core facility platform and to jointly secure external research grants. Establish joint appointments or ADjunct Professorship between Faculties of Dentistry, Engineering, Medicine, and Science. Recruitment RAP, PDF and RPG in these areas. Plan a unique integration between academia, clinical medicine and industry which enable biotechnology transfer.

Project Title:	Spinal perfusion imaging in cervical myelopathy patients
Investigator(s):	Luk KDK, Yang ES, Hu Y, Wu EX
Department:	Orthopaedics and Traumatology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2006

Abstract:

The objective of this project is to apply perfusion imaging (PI), a magnetic resonance dynamic imaging technique, to investigate the haemoglobin status of the cervical spinal cord, which may reveal the mechanism of surgical treatment on cervical spondylotic myelopathy (CSM). CSM is the most common spinal cord disorder affecting the elderly, and its incidence has increased significantly in recent years with the aging trend in the population in Hong Kong. Currently, the problem faced is that the mechanism of surgical treatment on CSM is not fully understood. The lack of understanding of the pathophysiology of CSM limits the rationale for improved treatment strategies. As well, the limit pathophysiology understanding also creates difficulties in the accurate and precise diagnosis of neurological functional deficits. The key issue here is to obtain a detailed understanding of the compression-associated pathomechanism of CSM and the changes after different surgical treatments. In this study, perfusion imaging will be applied to investigate the haemoglobin status of the cervical spinal cord and the relevant changes regarding different surgical treatments.

List of Research Outputs

Abbah S.A., Lu W.W., Luk K.D.K., Cheung K.M.C., Liu W., Chan D., Li Z. and Leong J.C.Y., New Bone Formation by Injected With Osteogenic Cells Confined in Sodium Alginate Microcapsules, The XXIII SICOT/SIROT Triennial World Congress held in Istanbul, Turkey, September 2-9, 2005.

Abbah S.A., Lu W.W., Cheung K.M.C., Zhao F., Chan D., Liu W.G., Li Z., Leong J.C.Y. and Luk K.D.K., Polymer encapsulated human osteoblastic cells form ectopic bone in mice, 52nd Annual Meeting of Orthopaedic Research Society, Chicago, Illinois, March 19-22, 2006.

Chan C.C.Y., Luk K.D.K. and Cheah K.S.E., Understanding the function of the SEDL gene and the molecular pathogenesis of spondyloepiphyseal dysplasia tarda, 10th Research Postgraduate Symposium, Faculty of Medicine, HKU. 2005.

Cheung K.M.C., Chen Y., Karppinen J., Chan D., Jim J.J.T., Luk K.D.K., Ala-Kokko L., Leong J.C.Y., Ott J., Sham P.C., Cheah K.S.E. and Song Y., Association of the Taq I allele in vitamin D receptor with degenerative disc disease and disc bulge in Chinese, Spine. 2006, 31(10): 1143-8.

Cheung K.M.C., Yeung K.W.K., Lu W.W. and Luk K.D.K., Gradual deformity correction by use of the super elastic property of nickel-titanium alloy: in-vivo demonstration in a goat model, 40th Annual Meeting of Scoliosis Research Society, Miami, Florida, USA, October 27-30, 2005.

Cheung K.M.C., Lu D., Zhang H. and Luk K.D.K., In-vivo demonstration of the effectiveness of thoracoscopic anterior release using the fulcrum bending radiograph: a report of five cases, European Spine Journal. 2005, 21: 1-5.

Cheung K.M.C., Yeung K.W.K., Lu W.W. and Luk K.D.K., Prediction of spinal flexibility in adolescent idiopathic scoliosis: a quantitative analysis by in-vivo correction force measurements, SICOT/SIROT 2005 XXIII World Congress, Istanbul, Turkey, September 2-9, 2005.

Cheung K.M.C., Jim J.J.T., Noponen-Hietala N., Ott J., Karppinen J., Sahraravand A., Luk K.D.K., Yip S.P., Sham P.C., Song Y., Leong J.C.Y., Cheah K.S.E., Ala-Kokko L. and Chan D., The Genetics of intervertebral disc degenertation, European Cells and Material: ECM VI/SRN I Spinal Motion Segment: From basic science to clinical application. Davos, Switzerland, July . 2005.

Cheung K.M.C., Wang T., Poon A.M.S., Carl A., Tranmer B., Hu Y.G., Luk K.D.K. and Leong J.C.Y., The effect of pinealectomy on scoliosis development in young non-human primates, Spine. 2005, 30(18): 2009-2013.

Cheung K.M.C., Lu W.W., Luk K.D.K., Wong C.T., Chan D., Shen J.X., Qiu G.X., Zheng Z.M., Li C.H., Liu S.L., Chan W.K. and Leong J.C.Y., Vertebroplasty by use of a strontium containing bioactive bone cement, Spine (Focus Issue). 2005, 30(17S): S84-S91.

Cheung W.Y., Arvinte D., Cheung K.M.C. and Luk K.D.K., Neurological recovery after surgical decompression in patients with cervical spondylotic myelopathy: a prospective study, 25th Annual Congress of the Hong Kong Orthopaedic Association. 2005.

Choi M.Y., Chan C., Chan D., Luk K.D.K., Cheah K.S.E. and Tanner J.A., Mechanistic insight into point mutations in sedlin that result in spondyloepiphyseal dysplasia tarda, FASEB Journal. 2006, 873.9.

Ho D.W.H., Cheung K.M.C., Chan D., Karppinen J., Yip S.P., Ott J., Luk K.D.K., Leong J.C.Y., Cheah K.S.E., Sham P.C. and Song Y., Linkage Analysis on familial Early-onset Degenerative Disc Disease(DDD), Hugo, HGM2006, 31 May - 3 June 2006 Helsinki, Finland.. 2006.

Ho J.P.Y., Wu S.L., Poon R.W.Y., Chung C.Y., Tjong S.C., Chu P.K., Yeung K.W.K., Lu W.W., Cheung K.M.C. and Luk K.D.K., Oxygen plasma treatment to restrain nickel out diffusion from porous nickel titanium orthopedic materials, 5th Asian-European International Conference on Plasma Surface Engineering, Qingdao, China, September 12-16, 2005.

Hu Y., Lam S.C.B., Chang C., Chan F.H.Y., Lu W.W. and Luk K.D.K., Adaptive Signal Enhancement of Somatosensory Evoked Potential for Spinal Cord Compression Detection: An Experimental Study., Comput Biol Med.. 2005, 35: 814-28.

Jim J.J.T., Noponen-Hietala N., Cheung K.M.C., Ott J., Karppinen J., Sahraravand A., Luk K.D.K., Yip S.P., Sham P.C., Song Y., Leong J.C.Y., Cheah K.S.E., Ala-Kokko L. and Chan D., The TRP2 allele of COL9A2 is an age-dependent risk factor for the development and severity of intervertebral disc degeneration, Spine. 2005, 30: 2735-2742.

Lai M.H., Luk K.D.K. and Kung A.W.C., ESR1 CA(n) repeat polymorphism is associated with increased risk of osteoporotic fractures and estrogen receptor alpha: mrna expression in bone, The IOF World Congress on Osteoporosis, 2-6 June 2006, Toronto, Canada. 2006.

Lau H.L., Ng M.Y.M., Cheung W.M.W., Paterson A.D., Sham P.C., Luk K.D.K., Chan V.N.Y. and Kung A.W.C., Assessment of linkage and association of 13 genetic loci with bone mineral density, Journal of Bone and Mineral Metabolism. 2006, 24: 226-34.

Lau H.L., Ng M.Y.M., Jin L., Paterson A., Sham P.C., Luk K.D.K., Chan V.N.Y. and Kung A.W.C., Test of linkage and association of 14 genetic loci with bone size, 27th Annual Meeting of the American Society for Bone & Mineral Research, 23-27 September 2005, Nashville, USA. 2005.

Li G., Ng M.C., Wong K.K., Luk K.D.K. and Yang E.S., Proton Density-weighted Spinal Fmri Induced By Acupuncture Stimulation At 0.2t. , In: John Gore, Magnetic Resonance Imaging / Invited Paper. 2005, 23: 998-999.

Li Z., Lu W.W., Ni G., Lam W.M.R., Chan D., Abbah S.A., Yang F., Cheung K.M.C. and Luk K.D.K., Strontium combined with calcium increases vertebral bone mineral density and stiffness in goats, 25th Annual Congress of the Hong Kong Orthopaedic Association, Nov 19-20 2005, Hong Kong. 2005.

Lu W.W., Abbah S.A., Cheung K.M.C., Chan D., Li Z.Y., Leong J.C.Y. and Luk K.D.K., Ectopic bone formation from Polymer-encapsulated osteogenic cells, 25th Annual Congress of the Hong Kong Orthopaedic Association, Nov 19-20 2005, Hong Kong. 2005.

Lu W.W., Wong C.T., Cheung K.M.C., Leong J.C.Y. and Luk K.D.K., In vitro mineralization of strontium-containing hydroxyapatite bioactive bone cement, SICOT/SIROT 2005 XXIII World Congress, Istanbul, Turkey, September 2-9, 2005.

Lu W.W., Ni G., Li Z., Tan B., Cheung K.M.C., Ngan A.H.W., Leong J.C.Y. and Luk K.D.K., Nanostructural and nanomechanics of the bone-cement interface in vivo, 25th Annual Congress of the Hong Kong Orthopaedic Association, Nov 19-20 2005, Hong Kong. 2005.

Luk K.D.K., Chen L. and Lu W.W., A stronger bicortical sacral pedicle screw fixation through the S1 endplate: an in-vitro cyclic loading and pull-out force evaluation, Spine. 2005, 30: 525-529.

Luk K.D.K., Ruan D.K., Lu D., Chow D.H.K. and Cheung K.M.C., Allogeneic intervertebral disc transplantation: Results of pre-clinical and clinical studies, European Cells and Materials. 2005, 10 (Supplement 3): 8.

Luk K.D.K., Anterior surgical approach to the cervicothoracic junction, 6th Combined Congress of Spine and Paediatric Sections, Asia Pacific Orthopaedic Association, Taipei, Taiwan, November 23-27, 2005.

Luk K.D.K., Approaches to the spine (from OC1 to sacrum), University of Alberta, Edmonton, Canada, December 6-9, 2005. 2005.

Luk K.D.K., Cervical myelopathy and its management, University of Alberta, Edmonton, Canada, December 6-9, 2005. 2005.

Luk K.D.K., Diagnosis and natural history, AOSpine Trauma and Degenerative Courses, Davos, Switzerland, December 11-16, 2005. 2005.

Luk K.D.K., Director of HK Editorial Office, Editorial Board of Chinese Journal of Orthopaedic Trauma since November 2005. 2005.

Luk K.D.K., Disc transplantation: from animal model to human trials, AO ASIF Advanced Concepts in the Management of Spinal Disorders, Sun Valley, Idaho, USA, February 23-26, 2006. 2006.

Luk K.D.K., Hong Kong operation for TB spine, AOSpine Trauma and Degenerative Courses, Davos, Switzerland, December 11-16, 2005. 2005.

Luk K.D.K., Intervertebral disc transplantation from animal studies to human clinical trial, University of Alberta, Edmonton, Canada, December 6-9, 2005. 2005.

Luk K.D.K., Intervertebral disc transplantation, AOSpine Trauma and Degenerative Courses, Davos, Switzerland, December 11-16, 2005. 2005.

Luk K.D.K., Member of Editorial Board of Journal of Orthopaedic Society and Research since December 2005. 2005.

Luk K.D.K., My worst case, AOSpine Advanced Course, Phuket, Thailand, March 16-18, 2006. 2006.

Luk K.D.K., Orthopaedic management of chronic spinal cord injury, First International Spinal Cord Injury Treatments and Trial Symposium, Hong Kong, December 17-20, 2005. 2005.

Luk K.D.K., Strategy for anterior approaches, AOSpine Advanced Course, Phuket, Thailand, March 16-18, 2006. 2006.

Luk K.D.K., Surgical techniques: En-bloc syondylectomy, AOSpine Trauma and Degenerative Courses, Davos, Switzerland, December 11-16, 2005. 2005.

Luk K.D.K., The development of NiTi shape memory alloy for scoliosis correction, University of Alberta, Edmonton, Canada, December 6-9, 2005. 2005.

Luk K.D.K., Treatment - anterior vs posterior, AOSpine Trauma and Degenerative Courses, Davos, Switzerland, December 11-16, 2005. 2005.

Ng M.C., Wong K.K.K., Li G., Lai S., Yang E.S., Hu Y. and Luk K.D.K., Proton-density-weighted spinal fMRI with sensorimotor stimulation at 0.2 T, Neuroimage. 2006, 29: 995-999.

Ng M.C., Wu E.X., Lau H.F., Hu Y., Yang E.S. and Luk K.D.K., Detection of ipsilateral and contralateral activation components in unilateral fingers-tapping using spinal BOLD fMRI., Proc. 14th ISMRM; 2006. Seattle, U.S.A.

Ng M.C., Hu Y., Wu E.X., Yang E.S. and Luk K.D.K., Diffusion Tensor-Based Fiber Tracking in Cervical Spinal Cord with a 3T MRI., IEEE Southwest Symposium on Image Analysis and Interpretation; 2006. Denver, Colorado, USA,, 76 - 80.

Ng M.C., Wong K.K., Li G., Lai S., Yang E.S., Hu Y. and Luk K.D.K., Proton Density-weighted Spinal Fmri With Sensorimotor Stimulation At 0.2t. , Neuroimage (accepted On 3rd Aug 2005.).. 2005.

Ni G., Chiu P.K.Y., Lu W.W., 徐兵., Li Z. and Luk K.D.K., Effect of weight-bearing on micromechanics and chemical components of the interface between bioactive bone cement and bone , Chinese Journal of Orthopaedic Trauma. 2006, 8: 143-147.

Ni G., Lu W.W., Xu B., Chiu P.K.Y., Yang C., Li Z.Y., Lam W.M., Luk K.D.K. and Lam W.M., Infacial behaviour of strontium-containing hydroxyapatite cement with cancellous and cortical bone, Biomaterials. 2006, 27: 5127-5133.

Ni G., Lu W.W., Tang B., Ngan A.H.W., Chiu P.K.Y., Cheung K.M.C., Li Z. and Luk K.D.K., Mechanical properties of interfaces between bone and strontium-containing hydroxyapatite bone cement under non- and weight-bearing conditions by nanoindentation, 52nd Annual Meeting of Orthopaedic Research Society, Chicago, Illinois, March 19-22, 2006.

Ni G., Lu W.W., Chiu P.K.Y., 王岩., 張永.剛., 郝立.波., Li Z., 盧世.壁. and Luk K.D.K., 活性骨水泥用于髖關節置換翻修的生物力學及組織學評價, Orthopaedic Journal of China. 2006, 14: 177.

Ni G., Lu W.W., Chiu P.K.Y., Li Z., Fong D.Y.T. and Luk K.D.K., Strontium-containing hydroxyapatite (Sr-HA) bioactive cement for primary hip replacement: An in vivo study, J Biomed Mater Res Part B: Appl Biomater. 2006, 77B: 409-415.

Ni G., Lu W.W., Tang B., Ngan A.H.K., Chiu P.K.Y., Li Z. and Luk K.D.K., What is the effect of weight-bearing on interface between bone cement and bone?, The 25th Annual Congress of Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2005, 9: S28.

Ni G.X., Choy Y.S., Lu W.W., Chiu P.K.Y., Li Z.Y., Tang B. and Luk K.D.K., Nano-mechanics of bone and bioactive bone cement interfaces in a load-bearing model, Biomaterials. 2006, 27(9): 1963-1970.

Qiu G.U.I.X.I.N.G., Zhang J.I.A.N.G.U.O., Wang Y.I.P.E.N.G., Xu H.O.N.G.G.U.A.N.G., Zhang J.I.A., Weng X.I.S.H.E.N.G., Lin J.I.N., Zhao Y.U., Shen J.I.A.N.X.I.O.N.G., Yang X.I.N.Y.U., Luk K.D.K., Lu D. and Lu W.W., A New Operative Classification of Idiopathic Scoliosis: A Peking Union Medical College Method, Spine. 2005, 30(12): 1419-1426.

Senkoylu A., Wong Y.W., Luk K.D.K. and Cheung K.M.C., Spontaneous rotational correction secondary to coronal curve correction in adolescent idiopathic scoliosis, 25th Annual Congress of the Hong Kong Orthopaedic Association, Nov 19-20 2005, Hong Kong. 2005.

Song Y., Ho D.W.H., Cheung K.M.C., Karppinen J., YIP S.P., Leong J.C.Y., Ott J., Luk K.D.K., Cheah K.S.E., Sham P.C. and Chan D., Genetic Linkage analysis of early onset degenerative disc disease in Southern Chinese., HUGO Pacific meeting & Asia-pacific Human Genetics Conference (HUGO-AP 2006), March 6-10, 2006 Academica Sinica, Taipei. 2006.

Takemitsu M., Cheung K.M.C., Wong Y.W., Cheung W.Y. and Luk K.D.K., The fifth cervical nerve root (C5) palsy after cervical Iaminoplasty and posterior fusion with instrumentation (investigation performed at the University of Hong Kong), 25th Annual Congress of the Hong Kong Orthopaedic Association, Nov 19-20 2005, Hong Kong. 2005.

Wang Y.J., Shi Q., Lu W.W., Cheung K.M.C., Aladin K.D.M., Li T.F., Dong Y.F., Zhou C.J., Zhou Q., Hu Z.J., Liu M., Bian Q., Li C.G., Luk K.D.K. and Leong J.C.Y., Cervical intervertebral disc degeneration induced by unbalanced dynamic and static forces: A novel in vivo rat model, Spine. 2006, 31(14): 1532-1538.

Wong W.N., Luk K.D.K., Leong J.C.Y., Wong S.F. and Wong K.K.Y., Continuous Dynamic Spinal Motion Analysis, Spine. 2006, 31(4): 414-419.

Wu S.L., Chu P.K., Liu X.M., Chung C.Y., Ho J.P., Chu C.L., Yeung K.W.K., Lu W.W., Luk K.D.K. and Cheung K.M.C., Surface Characteristics, Mechanical Properties, and Cytocompatibility of Oxygen Plasma-Implanted Porous Nickel Titanium Shape Memory Alloy, Journal of Biomedical Materials Research: Part A. 2006, 79A: 139-146.

Yeung K.W.K., Lu W.W., Luk K.D.K. and Cheung K.M.C., A Novel design of spinal implant coupling by the use of shape memory effect of nickel titanium alloys, SICOT/SIROT 2005 XXIII World Congress, Istanbul, Turkey, September 2-9, 2005.

Yeung K.W.K., Lu W.W., Luk K.D.K. and Cheung K.M.C., A novel "smart" spinal implant locking mechanism based on nickel-titanium alloy, 40th Annual Meeting of Scoliosis Research Society, Miami, Florida, USA, October 27-30, 2005.

Yeung K.W.K., Cheung K.M.C., Lu W.W., Luk K.D.K. and Leong J.C.Y., A novel method for gradual scoliosis correction using the superelastic effect of nickel titanium alloys, SICOT/SIROT 2005 XXIII World Congress, Istanbul, Turkey, September 2-9, 2005.

Yeung K.W.K., Lu W.W., Luk K.D.K. and Cheung K.M.C., A smart locking mechanism for orthopaedic implants, 52nd Annual Meeting of Orthopaedic Research Society, Chicago, Illinois, March 19-22, 2006.

Yeung K.W.K., Lu W.W., Luk K.D.K. and Cheung K.M.C., A “Smart” Locking Mechanism For All Orthopaedic Implants, 25th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 19-20, 2005.

Yeung K.W.K., Lu W.W., Luk K.D.K. and Cheung K.M.C., Progressive deformity correction using the superelastic property of nickel-titanium alloy: in-vivo demonstration in a goat model, 52nd Annual Meeting of Orthopaedic Research Society, Chicago, Illinois, March 19-22, 2006.

Yeung K.W.K., Chan Y.L., Chan S.C.W., Liu X.Y., Chung C.Y., Chu P.K., Lu W.W., Luk K.D.K., Chan D. and Cheung K.M.C., Suppression of nickel release in nickel-titanium alloys by plasma immersion ion implantation surface treatment: towards a new generation of "smart" orthopaedic implants, 33rd IEEE International Conference on Plasma Science, Traverse City, Michigan, U.S.A., June 4-8, 2006.

Researcher : Ng MC

List of Research Outputs

Ng M.C., Wong K.K.K., Li G., Lai S., Yang E.S., Hu Y. and Luk K.D.K., Proton-density-weighted spinal fMRI with sensorimotor stimulation at 0.2 T, Neuroimage. 2006, 29: 995-999.

Ng M.C., Wu E.X., Lau H.F., Hu Y., Yang E.S. and Luk K.D.K., Detection of ipsilateral and contralateral activation components in unilateral fingers-tapping using spinal BOLD fMRI., Proc. 14th ISMRM; 2006. Seattle, U.S.A.

Ng M.C., Hu Y., Wu E.X., Yang E.S. and Luk K.D.K., Diffusion Tensor-Based Fiber Tracking in Cervical Spinal Cord with a 3T MRI., IEEE Southwest Symposium on Image Analysis and Interpretation; 2006. Denver, Colorado, USA,, 76 - 80.

Ng M.C., Wong K.K., Li G., Lai S., Yang E.S., Hu Y. and Luk K.D.K., Proton Density-weighted Spinal Fmri With Sensorimotor Stimulation At 0.2t. , Neuroimage (accepted On 3rd Aug 2005.).. 2005.

Researcher : Ng MC

List of Research Outputs

Ng M.C., Wong K.K.K., Li G., Lai S., Yang E.S., Hu Y. and Luk K.D.K., Proton-density-weighted spinal fMRI with sensorimotor stimulation at 0.2 T, Neuroimage. 2006, 29: 995-999.

Ng M.C., Wong K.K., Li G., Lai S., Yang E.S., Hu Y. and Luk K.D.K., Proton Density-weighted Spinal Fmri With Sensorimotor Stimulation At 0.2t. , Neuroimage (accepted On 3rd Aug 2005.).. 2005.

Researcher : Ng TP

List of Research Outputs

Kuong E., Ng T.P., Wong H.M., Chiu P.K.Y., Tang W.M. and Yau P.W.P., Radiographic and clinical measurement of knee flexion after total knee arthroplasty and the weight of weight-bearing , The 25th Annual Congress of Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2005, 9: S18.

Liu K., Chiu P.K.Y., Zhang S., Tang W.M., Ng T.P. and Yau P.W.P., Combined linked-unlinked total elbow arthroplasty: short-term results of 11 elbows, The 25th Annual Congress of Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2005, 9: S57.

Ng T.P., Zhu Y. and Chiu P.K.Y., Cementless acetabular component inserted without screws: the effect of immediate weight-bearing, The 25th Annual Congress of Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2005, 9: S56.

Yau P.W.P., Chiu P.K.Y., Ng T.P. and Tang W.M., Incidence and severity of femoral and tibial bowing among Chinese patients: how it effects preoperative planning in total knee replacement, The 25th Annual Congress of Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2005, 9: S60.

Yau P.W.P., Leung A., Chiu P.K.Y., Tang W.M. and Ng T.P., Intra-observer errors in obtaining visually selected anatomic landmarks during registration process in non-image based navigation assisted TKR - A cadaveric experiment, The MIS Meets CAOS Symposium and Instructional Academy. Less and minimally invasive surgery for joint arthroplasty: Fact and fiction. 2005, 253-262.

Yau P.W.P., Leung A., Chiu P.K.Y., Tang W.M. and Ng T.P., Intra-observer errors in registration process in non-image based navigation assisted total knee replacement, J Bone Joint Surg Br Orthopaedic Proceedings. 2006, 88-B: 313.

Yau P.W.P., Leung A., Chiu P.K.Y., Tang W.M. and Ng T.P., Intra-observer errors in registration process in non-image based navigation, The 54th Annual Congress of the New Zealand Orthopaedic Association Annual Scientific Meeting. 2005, 15:52.

Yau P.W.P., Leung A., Chiu P.K.Y., Tang W.M. and Ng T.P., Intraobserver errors in obtaining visually selected anatomic landmarks during registration process in nonimage-based navigation-assisted total knee arthroplasty: a cadaveric experiment, Journal of Arthroplasty. 2005, 20(5): 591-601.

Zhang S.D., Tan J.W., Chiu P.K.Y. and Ng T.P., Comparison of the fatigue properties of bone cement specimens prepared with different monomer storing temperature and different polymerization ambient temperatures, 不同溫度保存單體在不同環境溫度下聚合的骨水泥抗疲勞性能比較, Chinese Journal of Orthopaedics. 2005, 25: 692-695.

Researcher : Ni G

List of Research Outputs

Li Z., Lu W.W., Ni G., Lam W.M.R., Chan D., Abbah S.A., Yang F., Cheung K.M.C. and Luk K.D.K., Strontium combined with calcium increases vertebral bone mineral density and stiffness in goats, 25th Annual Congress of the Hong Kong Orthopaedic Association, Nov 19-20 2005, Hong Kong. 2005.

Lu W.W., Ni G., Li Z., Tan B., Cheung K.M.C., Ngan A.H.W., Leong J.C.Y. and Luk K.D.K., Nanostructural and nanomechanics of the bone-cement interface in vivo, 25th Annual Congress of the Hong Kong Orthopaedic Association, Nov 19-20 2005, Hong Kong. 2005.

Ni G., Chiu P.K.Y., Lu W.W., 徐兵., Li Z. and Luk K.D.K., Effect of weight-bearing on micromechanics and chemical components of the interface between bioactive bone cement and bone , Chinese Journal of Orthopaedic Trauma. 2006, 8: 143-147.

Ni G., Lu W.W., Xu B., Chiu P.K.Y., Yang C., Li Z.Y., Lam W.M., Luk K.D.K. and Lam W.M., Infacial behaviour of strontium-containing hydroxyapatite cement with cancellous and cortical bone, Biomaterials. 2006, 27: 5127-5133.

Ni G., Lu W.W., Tang B., Ngan A.H.W., Chiu P.K.Y., Cheung K.M.C., Li Z. and Luk K.D.K., Mechanical properties of interfaces between bone and strontium-containing hydroxyapatite bone cement under non- and weight-bearing conditions by nanoindentation, 52nd Annual Meeting of Orthopaedic Research Society, Chicago, Illinois, March 19-22, 2006.

Ni G., Lu W.W., Chiu P.K.Y., 王岩., 張永.剛., 郝立.波., Li Z., 盧世.壁. and Luk K.D.K., 活性骨水泥用于髖關節置換翻修的生物力學及組織學評價, Orthopaedic Journal of China. 2006, 14: 177.

Ni G., Lu W.W., Chiu P.K.Y., Li Z., Fong D.Y.T. and Luk K.D.K., Strontium-containing hydroxyapatite (Sr-HA) bioactive cement for primary hip replacement: An in vivo study, J Biomed Mater Res Part B: Appl Biomater. 2006, 77B: 409-415.

Ni G., Lu W.W., Tang B., Ngan A.H.K., Chiu P.K.Y., Li Z. and Luk K.D.K., What is the effect of weight-bearing on interface between bone cement and bone?, The 25th Annual Congress of Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2005, 9: S28.

Researcher : Ni G

List of Research Outputs

Researcher : Senkoylu A

List of Research Outputs

Senkoylu A., Wong Y.W., Luk K.D.K. and Cheung K.M.C., Spontaneous rotational correction secondary to coronal curve correction in adolescent idiopathic scoliosis, 25th Annual Congress of the Hong Kong Orthopaedic Association, Nov 19-20 2005, Hong Kong. 2005.

Researcher : Tang WM

Project Title:	The alteration of CIP1/WAF1 gene in osteosarcoma: correlation with bone destruction, p53 expression, cell proliferation, cell cycle and clinical data
Investigator(s):	Tang WM, Chung SSM, Chiu PKY, Liao WM, Chow SP
Department:	Orthopaedics and Traumatology
Source(s) of Funding:	University Research Committee / Committee on Research and Conference Grants - General Award
Start Date:	07/1997

Abstract:

To investigate the role of the tumour suppressor gene: CIP1/WAF1 on the pathogenesis and aggressiveness on osteosarcoma; to examine the behaviour of osteosarcoma at the molecular level.

Project Title:	Enhancement of experimental fracture healing in using tradition Chinese medicine
Investigator(s):	Tang WM, Chu YW, Chow SP
Department:	Orthopaedics and Traumatology
Source(s) of Funding:	Low Budget High Impact Programme
Start Date:	11/2001

Abstract:

To determine the effect of these TCM prescriptions on fracture healing in a experimental fracture animal model.

Project Title:	Quantitative assessment of post-operative activities of Chinese patients underwent total hip arthroplasty: a prospective study on the effects of level of activity on polyethylene wear
Investigator(s):	Tang WM
Department:	Orthopaedics and Traumatology
Source(s) of Funding:	Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:	07/2005
Completion Date:	06/2006

Abstract:

N/A

List of Research Outputs

Kuong E., Ng T.P., Wong H.M., Chiu P.K.Y., Tang W.M. and Yau P.W.P., Radiographic and clinical measurement of knee flexion after total knee arthroplasty and the weight of weight-bearing , The 25th Annual Congress of Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2005, 9: S18.

Lie W.H., Yau P.W.P., Wong S., Wong L., Chiu P.K.Y. and Tang W.M., Inter- and Intra-observer errors in measuring transepicondylar axis of distal femur using computerized tomogram, The 25th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2005, 9: S16.

Liu K., Chiu P.K.Y., Zhang S., Tang W.M., Ng T.P. and Yau P.W.P., Combined linked-unlinked total elbow arthroplasty: short-term results of 11 elbows, The 25th Annual Congress of Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2005, 9: S57.

Mok T.M.Y., Wong S.Y., Chan D.T.M., Tang W.M., Wong R.W.S. and Lau W.C.S., Necrotising Fasciitis in Rheumatic Diseases, Lupus. 2006, 15: 380-3.

Tang W.M. and Chiu P.K.Y., Assessment of pelvic rotation: A comparison of 3 methods , The 25th Annual Congress of Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2005, 9: S55.

Tang W.M. and Chiu P.K.Y., Avascular necrosis of femoral head: a short review, Hong Kong Bulletin on Rheumatic Diseases. 2005, 5: 49-51.

Yau P.W.P., Yan C.H., Wong L.S., Leung A., Chiu P.K.Y. and Tang W.M., Errors in obtaining visually selected anatomical landmarks during registration process in non-image-based navigation-assisted total knee replacement: comparison between minimal incision approach and conventional incision approach, The 25th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2005, 9: S17.

Yau P.W.P., Chiu P.K.Y., Ng T.P. and Tang W.M., Incidence and severity of femoral and tibial bowing among Chinese patients: how it effects preoperative planning in total knee replacement, The 25th Annual Congress of Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2005, 9: S60.

Yau P.W.P., Leung A., Chiu P.K.Y., Tang W.M. and Ng T.P., Intra-observer errors in obtaining visually selected anatomic landmarks during registration process in non-image based navigation assisted TKR - A cadaveric experiment, The MIS Meets CAOS Symposium and Instructional Academy. Less and minimally invasive surgery for joint arthroplasty: Fact and fiction. 2005, 253-262.

Yau P.W.P., Leung A., Chiu P.K.Y., Tang W.M. and Ng T.P., Intra-observer errors in registration process in non-image based navigation assisted total knee replacement, J Bone Joint Surg Br Orthopaedic Proceedings. 2006, 88-B: 313.

Yau P.W.P., Leung A., Chiu P.K.Y., Tang W.M. and Ng T.P., Intra-observer errors in registration process in non-image based navigation, The 54th Annual Congress of the New Zealand Orthopaedic Association Annual Scientific Meeting. 2005, 15:52.

Yau P.W.P., Leung A., Chiu P.K.Y., Tang W.M. and Ng T.P., Intraobserver errors in obtaining visually selected anatomic landmarks during registration process in nonimage-based navigation-assisted total knee arthroplasty: a cadaveric experiment, Journal of Arthroplasty. 2005, 20(5): 591-601.

Yau P.W.P., Chiu P.K.Y., Tang W.M. and Tang W.M., Residual posterior femoral condyle osteophyte affects the flexion range after total knee replacement, International Orthopaedics (SICOT). 2005, 29: 375-379.

Researcher : Wong CT

List of Research Outputs

Cheung K.M.C., Lu W.W., Luk K.D.K., Wong C.T., Chan D., Shen J.X., Qiu G.X., Zheng Z.M., Li C.H., Liu S.L., Chan W.K. and Leong J.C.Y., Vertebroplasty by use of a strontium containing bioactive bone cement, Spine (Focus Issue). 2005, 30(17S): S84-S91.

Lu W.W., Wong C.T., Cheung K.M.C., Leong J.C.Y. and Luk K.D.K., In vitro mineralization of strontium-containing hydroxyapatite bioactive bone cement, SICOT/SIROT 2005 XXIII World Congress, Istanbul, Turkey, September 2-9, 2005.

Researcher : Wong CT

List of Research Outputs

Researcher : Wong HM

List of Research Outputs

Kuong E., Ng T.P., Wong H.M., Chiu P.K.Y., Tang W.M. and Yau P.W.P., Radiographic and clinical measurement of knee flexion after total knee arthroplasty and the weight of weight-bearing , The 25th Annual Congress of Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2005, 9: S18.

Researcher : Wong JWC

List of Research Outputs

Lee W.M., Leung H.B. and Wong J.W.C., Iatrogenic bilateral pneumothorax arising from acupuncture: a case report, Journal of Orthopaedic Surgery. 2005, 13(3): 300-302.

Researcher : Wong JWK

List of Research Outputs

Yip D.K.H. and Wong J.W.K., Technical note: A simple device in shoulder arthroscopy: the suture assistant, The Journal of Arthroscopic and Related Surgery. 2005, 21(9): 1151.

Researcher : Wong WN

List of Research Outputs

Wong W.N., Luk K.D.K., Leong J.C.Y., Wong S.F. and Wong K.K.Y., Continuous Dynamic Spinal Motion Analysis, Spine. 2006, 31(4): 414-419.

Researcher : Wong YW

List of Research Outputs

Senkoylu A., Wong Y.W., Luk K.D.K. and Cheung K.M.C., Spontaneous rotational correction secondary to coronal curve correction in adolescent idiopathic scoliosis, 25th Annual Congress of the Hong Kong Orthopaedic Association, Nov 19-20 2005, Hong Kong. 2005.

Takemitsu M., Cheung K.M.C., Wong Y.W., Cheung W.Y. and Luk K.D.K., The fifth cervical nerve root (C5) palsy after cervical Iaminoplasty and posterior fusion with instrumentation (investigation performed at the University of Hong Kong), 25th Annual Congress of the Hong Kong Orthopaedic Association, Nov 19-20 2005, Hong Kong. 2005.

Researcher : Yang F

List of Research Outputs

Li Z., Lu W.W., Ni G., Lam W.M.R., Chan D., Abbah S.A., Yang F., Cheung K.M.C. and Luk K.D.K., Strontium combined with calcium increases vertebral bone mineral density and stiffness in goats, 25th Annual Congress of the Hong Kong Orthopaedic Association, Nov 19-20 2005, Hong Kong. 2005.

Researcher : Yau PWP

List of Research Outputs

Kuong E., Ng T.P., Wong H.M., Chiu P.K.Y., Tang W.M. and Yau P.W.P., Radiographic and clinical measurement of knee flexion after total knee arthroplasty and the weight of weight-bearing , The 25th Annual Congress of Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2005, 9: S18.

Lie W.H., Yau P.W.P., Wong S., Wong L., Chiu P.K.Y. and Tang W.M., Inter- and Intra-observer errors in measuring transepicondylar axis of distal femur using computerized tomogram, The 25th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2005, 9: S16.

Liu K., Chiu P.K.Y., Zhang S., Tang W.M., Ng T.P. and Yau P.W.P., Combined linked-unlinked total elbow arthroplasty: short-term results of 11 elbows, The 25th Annual Congress of Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2005, 9: S57.

Yau P.W.P., Leung A., Liu K.G., Wong L.L.S. and Chiu P.K.Y., Can minimal incision approach be combined with computer assisted navigation total knee replacement? A cadaveric study on the errors in obtaining visually selected anatomical landmarks during registration process, The 6th Annual Meeting of CAOS-International Proceedings. 2006, 586-589.

Yau P.W.P., Leung A., Liu K.G., Yan C.H., Wong L.L.S. and Chiu P.K.Y., Errors in obtaining visually selected anatomic landmarks during registration process in non-image based navigation assisted total knee replacement - comparison between minimal incision approach and conventional incision approach, The 3rd Annual Meeting of the Asian Society for Computer Assisted Orthopaedic Surgery. 2006, 40.

Yau P.W.P., Yan C.H., Wong L.S., Leung A., Chiu P.K.Y. and Tang W.M., Errors in obtaining visually selected anatomical landmarks during registration process in non-image-based navigation-assisted total knee replacement: comparison between minimal incision approach and conventional incision approach, The 25th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2005, 9: S17.

Yau P.W.P., Chiu P.K.Y., Ng T.P. and Tang W.M., Incidence and severity of femoral and tibial bowing among Chinese patients: how it effects preoperative planning in total knee replacement, The 25th Annual Congress of Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2005, 9: S60.

Yau P.W.P., Leung A., Chiu P.K.Y., Tang W.M. and Ng T.P., Intra-observer errors in obtaining visually selected anatomic landmarks during registration process in non-image based navigation assisted TKR - A cadaveric experiment, The MIS Meets CAOS Symposium and Instructional Academy. Less and minimally invasive surgery for joint arthroplasty: Fact and fiction. 2005, 253-262.

Yau P.W.P., Intra-observer errors in obtaining visually selected anatomic landmarks during registration process in non-image based navigation assisted TKR - a cadaveric experiment, "MIS Meets CAOS Symposium and Instructional Academy. Less and Minimally Invasive Surgery for Joint Arthroplasty: Fact and Fiction" organized by MIS Meets CAOS Symposium, October 20-22, 2005. 2005.

Yau P.W.P., Leung A., Chiu P.K.Y., Tang W.M. and Ng T.P., Intra-observer errors in registration process in non-image based navigation assisted total knee replacement, J Bone Joint Surg Br Orthopaedic Proceedings. 2006, 88-B: 313.

Yau P.W.P., Leung A., Chiu P.K.Y., Tang W.M. and Ng T.P., Intra-observer errors in registration process in non-image based navigation, The 54th Annual Congress of the New Zealand Orthopaedic Association Annual Scientific Meeting. 2005, 15:52.

Yau P.W.P., Intra-observer errors in registration process in non-image based navigation, The 54th Annual Congress of the New Zealand Orthopaedic Association Annual Scientific Meeting organized by New Zealand Orthopaedic Association, October 2-5, 2005, Christichurch, New Zealand. 2005.

Yau P.W.P., Leung A., Chiu P.K.Y., Tang W.M. and Ng T.P., Intraobserver errors in obtaining visually selected anatomic landmarks during registration process in nonimage-based navigation-assisted total knee arthroplasty: a cadaveric experiment, Journal of Arthroplasty. 2005, 20(5): 591-601.

Yau P.W.P., Non-imaged based navigation assisted total knee replacement - is it accurate?, The 2005 china Insall Club Meeting. 2005, 69.

Yau P.W.P., Chiu P.K.Y., Tang W.M. and Tang W.M., Residual posterior femoral condyle osteophyte affects the flexion range after total knee replacement, International Orthopaedics (SICOT). 2005, 29: 375-379.

Researcher : Yee AFY

List of Research Outputs

Yee A.F.Y., Cheung K.M.C. and Chan D., Gene and Protein Expression Profiles of the Intervertebral Disc: In Health and Disease - A General Overview, 10th Research Postgraduate Symposium, Faculty of Medicine, HKU, December 3, 2005.

Researcher : Yeung KWK

Project Title:	Development Of Novel Locking Mechanism For Orthopaedic Implants
Investigator(s):	Yeung KWK, Cheung KMC, Lu WW
Department:	Orthopaedics and Traumatology
Source(s) of Funding:	Small Project Funding
Start Date:	12/2005
Completion Date:	02/2007

Abstract:

Objective: To develop an automatic locking mechanism based on the super-elastic and memory effects of nickel-titanium (NiTi) alloy. This locking mechanism will reduce the conventional post-operation complications induced by implant loosening. Introduction: All current internal and external orthopaedic implant locking mechanisms involve the tightening of a nut against the rod and screw head to form a coupling. Surgeons are required to apply a torque over the couplings when they lock these conventional implants. However, there are no standard guidelines regarding how much torque one should apply to be able to secure the lock. In most cases, the surgeon locks it as tightly as possible, which often fails to secure the implant in the long term. If the torque is too small, this will affect the overall mechanical stability of the spinal construct. Loss of correction and implant failure may also occur due to inadequate mechanical stability [1]. Furthermore, daily body movements can wear the rod and the locking mechanism (fretting) [2,3]. Fretting will inevitably generate debris and the coupling subsequently becomes loose, thereby resulting in some complications such as implant-induced osteolysis, pseudarthrosis, subacute low-grade implant infection, late operative site pain and abnormal metal concentration in serum [2-5]. Therefore, the invention of a new locking mechanism is needed. Our thought is to develop a novel locking mechanism with a self-retightening ability once fretting occurs. Hopefully, we can achieve this idea through the unique properties found in nickel-titanium (NiTi) alloys - the super-elastic and shape-memory effects. The NiTi material is malleable under cold temperatures, and is able to remember and recover its original shape when heated, hence the term "shape-memory" [7]. Super-elasticity is a state when the force is always constant under deformation strains that range from 1% to 8% [6,8]. The way NiTi works is analogous to how elastic materials such as rubber work, where the recovery force is proportional to the degree of deformation. Our previously patented thermal treatment protocol and paper have shown the ability to optimize the super-elastic and memory effect at human body temperature [9,10]. With the use of these special properties of NiTi alloy, the new locking mechanism may have the ability to automatically retighten once fretting occurs. Therefore, the complications induced by implant loosening can be solved. Hypothesis: A new locking mechanism made out of NiTi alloy which has the unqiue properties of super-elasticity and memory effect has the ability of self-retightening once fretting occurs. Therefore, this new locking mechanism is able to tackle the post-operation complications induced by implant loosening. The key issues are: - the ability to reduce the post-operation complications induced by implant loosening. - to ensure that the hypothesis of self-retightening mechanism is workable and that the lock behaves properly under in-vivo conditions. References: [1] Lim TH, An HS. Biomechanics of spinal instrumentation. In: An HS, Cotler JM, editors. Spinal Instrumentation. Philadelphia: Lippincott Williams & Wilkins; 1999. p 59-72. [2] Senaran H, Atilla P, Kaymaz F, Acaroglu E, Surat A. Ultrastructural Analysis of Metallic Debris and Tissue Reaction Around Spinal Implants in Patients With Late Operative Site Pain. Spine August 1 2004;29(15):1618-1623. [3] Kasai Y, Iida R, Uchida A. Metal Concentrations in the Serum and Hair of Patients With Titanium Alloy Spinal Implants. Spine 2003;28(12):1320-1326. [4] Hallab NJ, Cunningham BW, Jacobs JJ. Spinal Implant Debris-Induced Osteolysis. Spine October 15 2003;28(20S)(Supplement):S125-S138. [5] Wang JC, Yu WD, Sandhu HS, Betts F, Bhuta S, Delamarter RB. Metal Debris From Titanium Spinal Implants. Spine May 1 1999;24(9):899. [6] Liu Y, McCormick PG. Criteria of Transformation Sequences in NiTi Shape Memory Alloys. Materials Transactions 1996;37(4):691-696. [7] Liu Y, Liu Y, Van Humbeeck J. Two-way Shape Memory Effect Developed by Martensite Deformation in NiTi. Acta Materialia 1999;47(1):199-209. [8] Melton KN, Mercier O. The mechanical properties of NiTi-based shape memory alloys. Acta Metallurgica 1981;29(2):393-398. [9] Yeung KWK, Cheung KMC, Lu WW, Chung CY. Optimization of thermal treatment parameters to alter austenitic phase transition temperature of NiTi alloy for medical implant. Materials Science and Engineering A 2004;383(2):213-218. [10] KWK Yeung, KMC Cheung, JCY Chung, WW Lu. Superelastic or Pseudoelastic Nickel Titanium Alloy for Use as Medical Implant by Setting the AF Transition Temperature below Body Temperature. US Non-Provisional Patent (No. 10/827,665). Filed: April 19, 2004.

List of Research Outputs

Aladin K.D.M., Lu W.W., Cheung K.M.C., Yeung K.W.K. and Chan D., Impact of Trp2 allele mutation of alpha-2 chain in collagen IX on the structural integrity of human annulus fibrosus, European Cells and Materials Symposium: Spinal Motion Segment: From Basic Science to Clinical Application, 4th to 7th July, 2005. Davos, Switzerland. 2005.

Aladin Kaderbatcha D.M., Lu W.W., Cheung K.M.C., Yeung K.W.K. and Chan D., Impact of the Trp2 allele mutation of the alpha-2 chain in collagen IX on the structural integrity of human annulus fibrosus., European Cells and Material: ECM VI/SRN I Spinal Motion Segment: From basic science to clinical application. Davos, Switzerland, July 2005 . 2005.

Cheung K.M.C., Yeung K.W.K., Chung J.C.Y. and Lu W.W., Device for correcting spinal deformities, Chinese Non-provisional Patent (No. 03824606.6). Filed: 16 November, 2005. 2005.

Cheung K.M.C., Yeung K.W.K., Lu W.W. and Luk K.D.K., Gradual deformity correction by use of the super elastic property of nickel-titanium alloy: in-vivo demonstration in a goat model, 40th Annual Meeting of Scoliosis Research Society, Miami, Florida, USA, October 27-30, 2005.

Cheung K.M.C., Yeung K.W.K., Lu W.W. and Luk K.D.K., Prediction of spinal flexibility in adolescent idiopathic scoliosis: a quantitative analysis by in-vivo correction force measurements, SICOT/SIROT 2005 XXIII World Congress, Istanbul, Turkey, September 2-9, 2005.

Cheung K.M.C., Yeung K.W.K., Chung J.C.Y. and Lu W.W., Shape memory material and method of making the same (Heat treatment protocol), Japan Non-provisional Patent (No. 100064746). Filed 19 April 2004. Publication date: 14 October 2005 . 2005.

Chu C.L., Pu Y.P., Yin L.H., Chung C.Y., Yeung K.W.K. and Chu P.K., Biomimetic deposition process of an apatite coating on NiTi shape memory alloy, Materials Letters. 2006, 60: 3002-3006.

Chu C.L., Wu S.L., Yeung K.W.K., Chung C.Y. and Chu P.K., Microstructure, mechanical properties and phase transformation behaviors of porous NiTi shape memory alloy fabricated by combustion synthesis, International Conference on Shape Memory and Superelastic Technologies. May 7-11, 2006. Asilomar Conference Center in Pacific Grove, California, USA.. 2006.

Ho J.P.Y., Wu S.L., Poon R.W.Y., Chung C.Y., Tjong S.C., Chu P.K., Yeung K.W.K., Lu W.W., Cheung K.M.C. and Luk K.D.K., Oxygen plasma treatment to restrain nickel out diffusion from porous nickel titanium orthopedic materials, 5th Asian-European International Conference on Plasma Surface Engineering, Qingdao, China, September 12-16, 2005.

Poon R.W., Ho J.P., Liu X.Y., Chung C.Y., Chu P.K., Yeung K.W.K., Lu W.W. and Cheung K.M.C., Formation of Titanium Nitride barrier layer in Nickel-Titanium shape memory alloys by nitrogen plasma immersion ion implantation for better corrosion resistance, Thin Solid Films. 2005, 488: 20-25.

Poon R.W., Ho J.P., Luk C.M., Liu X.Y., Chung C.Y., Chu P.K., Yeung K.W.K., Lu W.W. and Cheung K.M.C., Improvement of Corrosion Resistance of NiTi Orthopedic Materials by Carbon Plasma Immersion Ion Implantation, Nuclear Instruments and Methods in Physics Research B. 2006, 242: 270-274.

Poon R.W.Y., Ho J.P.Y., Liu X.Y., Chung C.Y., Tjong P.K., Chu P.K., Yeung K.W.K., Lu W.W. and Cheung K.M.C., Improvement of surface properties of orthopedic nickel-titanium shape memory alloys by nitrogen plasma immersion ion implantation, 14th International Conference on Surface Modification of Materials by Ion Beams (SMMIB), September 4-9, 2005, Kusadasi, Turkey. 2005.

Poon R.W.Y., Ho J.P.Y., Liu X.Y., Chung C.Y., Chu P.K., Yeung K.W.K., Lu W.W. and Cheung K.M.C., Improvements of anti-corrosion and mechanical properties of NiTi orthopedic materials by acetylene, nitrogen and oxygen plasma immersion ion implantation, Nuclear Instruments and Methods in Physics Research B. 2005, 237: 411-416.

Wu S.L., Liu X.M., Chung C.Y., Yeung K.W.K., Chu P.K., Chu C.L., Lu W.W. and Cheung K.M.C., Nickel relaese behavior and biocompatibility of oxidized porous NiTi, European Materials Research Society 2006 Spring Meeting, Nice, France, May 29 to June 2, 2006.

Wu S.L., Liu X.M., Chu P.K., Chung C.Y., Chu C.L. and Yeung K.W.K., Phase transformation behaviour of porous NiTi alloys fabricated by capsule-free hot isostatic pressing, Internatonal Symposium on Functional Materials, Kuala Lumpur, Malaysia, December 6-8, 2005.

Wu S.L., Chu P.K., Liu X.M., Chung C.Y., Ho J.P., Chu C.L., Yeung K.W.K., Lu W.W., Luk K.D.K. and Cheung K.M.C., Surface Characteristics, Mechanical Properties, and Cytocompatibility of Oxygen Plasma-Implanted Porous Nickel Titanium Shape Memory Alloy, Journal of Biomedical Materials Research: Part A. 2006, 79A: 139-146.

Yeung K.W.K., Lu W.W., Luk K.D.K. and Cheung K.M.C., A Novel design of spinal implant coupling by the use of shape memory effect of nickel titanium alloys, SICOT/SIROT 2005 XXIII World Congress, Istanbul, Turkey, September 2-9, 2005.

Yeung K.W.K., Lu W.W., Luk K.D.K. and Cheung K.M.C., A novel "smart" spinal implant locking mechanism based on nickel-titanium alloy, 40th Annual Meeting of Scoliosis Research Society, Miami, Florida, USA, October 27-30, 2005.

Yeung K.W.K., Cheung K.M.C., Lu W.W., Luk K.D.K. and Leong J.C.Y., A novel method for gradual scoliosis correction using the superelastic effect of nickel titanium alloys, SICOT/SIROT 2005 XXIII World Congress, Istanbul, Turkey, September 2-9, 2005.

Yeung K.W.K., Lu W.W., Luk K.D.K. and Cheung K.M.C., A smart locking mechanism for orthopaedic implants, 52nd Annual Meeting of Orthopaedic Research Society, Chicago, Illinois, March 19-22, 2006.

Yeung K.W.K., Lu W.W., Luk K.D.K. and Cheung K.M.C., A “Smart” Locking Mechanism For All Orthopaedic Implants, 25th Annual Congress of the Hong Kong Orthopaedic Association, Hong Kong, November 19-20, 2005.

Yeung K.W.K., Poon R.W., Liu X.Y., Ho J.P., Chung C.Y., Chu P.K., Lu W.W., Chan D. and Cheung K.M.C., Corrosion resistance, mechanical properties and cyto-compatibility of NiTi shape memory alloys using nitrogen, and oxygen plasma immersion ion implantation, Journal of Biomedical Materials Research: Part A. 2005, 75: 256-67.

Yeung K.W.K. and Cheung K.M.C., Development of a Novel Spinal Implant for Progressive Scoliosis Correction, Young Scientist Award 2005 by The Hong Kong Institute of Science, HK, Oct 2005. 2005.

Yeung K.W.K., Development of a novel spinal implant for progressive scoliosis correction, Physics Department of Hong Kong University of Science and Technology. 2005.

Yeung K.W.K., Poon R.W.Y., Liu X.Y., Ho J.P.Y., Chung C.Y., Chu P.Y., Lu W.W., Chan D. and Cheung K.M.C., Enhanced corrosion resistance and biocompatibility by plasma implantation of nickel-titanium alloys: An in-vitro and surface chemical study, 51st Annual Meeting of Orthopaedic Research Society, Washington DC, U.S.A., 2005.

Yeung K.W.K., Hong Kong Orthopaedic Association Traveling Fellowship, Hong Kong Orthopaedic Association. 2005.

Yeung K.W.K., Poon R.W.Y., Liu X., Ho J.P.Y., Chung C.Y., Chu P.K., Lu W.W., Chan D. and Cheung K.M.C., Nickel suppression in Ni-Ti alloys by plasma immersion ion implantation surface treatment: new materials for orthopaedic implantation, European Cells and Materials. 2005, 10(3): 78.

Yeung K.W.K., Poon R.W.Y., Liu X., Ho J.P.Y., Chung C.Y., Chu P.K., Wu W.W., Chan D. and Cheung K.M.C., Nickle suppression in Nickle-titanium alloys by plasma immersion ion implanation surface treatmentL new material for orthopaedic implanation., European Cells and Material: ECM VI/SRN I Spinal Motion Segment: From basic science to clinical application. Davos, Switzerland, July 2005 . 2005.

Yeung K.W.K., Poon R.W., Liu X.Y., Chung C.Y., Chu P.K., Lu W.W., Chan D. and Cheung K.M.C., Nitrogen Plasma Immersion Ion Implanted Nickel Titanium Alloys For Orthopedic Use, 5th Asian-European International Conference on Plasma Surface Engineering, Qingdao, China, Sept 12-16, 2005.. 2005.

Yeung K.W.K., Poon R.W.Y., Liu X.Y., Chung C.Y., Chu P.K., Lu W.W., Chan D. and Cheung K.M.C., Nitrogen plasma immersion ion implanted nickel titanium alloys for orthopedic use, 5th Asian-European International Conference on Plasma Surface Engineering, Qingdao, PR China, September 12-16. 2005.

Yeung K.W.K., Lu W.W., Luk K.D.K. and Cheung K.M.C., Progressive deformity correction using the superelastic property of nickel-titanium alloy: in-vivo demonstration in a goat model, 52nd Annual Meeting of Orthopaedic Research Society, Chicago, Illinois, March 19-22, 2006.

Yeung K.W.K., Chan Y.L., Chan S.C.W., Liu X.Y., Chung C.Y., Chu P.K., Lu W.W., Luk K.D.K., Chan D. and Cheung K.M.C., Suppression of nickel release in nickel-titanium alloys by plasma immersion ion implantation surface treatment: towards a new generation of "smart" orthopaedic implants, 33rd IEEE International Conference on Plasma Science, Traverse City, Michigan, U.S.A., June 4-8, 2006.

Yeung K.W.K., Chu P.K., Poon R.W.Y., Lu W.W. and Cheung K.M.C., Surface treated shape memory materials by the use of plasma immersion ion implantation and deposition or related ion-beam and plasma-based techniques for biomedical applications, US Non-Provisional Patent (No. 11/331264). Filed on January 11, 2006. 2006.

Yeung K.W.K., Young Scientist Award, 青年科學家獎, Hong Kong Institution of Science. 香港科學會, 2005.

Yuan B., Chung J.C.Y., Yeung K.W.K. and Cheung K.M.C., Pseudoelastic porous shape memory materials for biomedical and engineering applications, US Provisional Patent filed 23 September 2005. 2005.

Researcher : Yip DKH

Project Title:	To evaluate biomechanically the strongest host bone and allograft bone docking site geometry - for application in bone transplant patients undergoing limb salvage surgery
Investigator(s):	Yip DKH, Chien EP
Department:	Orthopaedics and Traumatology
Source(s) of Funding:	Low Budget High Impact Programme
Start Date:	11/2000

Abstract:

To find the strongest, bone docking site geometry between the host bone and massive bone allograft in limb salvage patients.

Project Title:	Biomechanical evaluation of the effect of incomplete cortical erosion of a diaphyseal long bone
Investigator(s):	Yip DKH
Department:	Orthopaedics and Traumatology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002

Abstract:

To determine the critical failure strength of a diaphyseal long bone which has been eroded by metastatic disease?

Project Title:	Strength reduction of suture due to abrasion of the interference screw
Investigator(s):	Yip DKH
Department:	Orthopaedics and Traumatology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2004

Abstract:

To compare the failure strength of two types of sutures before and after the abrasive wear by the screw against bone.

List of Research Outputs

Yip D.K.H. and Wong J.W.K., A Simple Device in Shoulder Arthroscopy: the Suture Assistant. , Arthroscopy. 2005.

Yip D.K.H. and Wong J.W.K., Technical note: A simple device in shoulder arthroscopy: the suture assistant, The Journal of Arthroscopic and Related Surgery. 2005, 21(9): 1151.

Yip D.K.H. and Wong J.W.K., The peashooter A device in Revision ACL surgery. , Arthroscopy . 2005, 21: 1010e1-1010e4.

Researcher : Yuen CK

List of Research Outputs

Yuen C.K., Opportunities for the use of bio-corrodible alloys in tissue engineering, Tissue Engineering. 2006, 12(4): 990-991.

Yuen C.K. and Ip W.Y., Opportunities for the use of bio-corrodible alloys in tissue engineering, Tissue Engineering Scientific Institute Annual Meeting, Shanghai, China, 25 October 2005.

Researcher : Zhang S

List of Research Outputs

Liu K., Chiu P.K.Y., Zhang S., Tang W.M., Ng T.P. and Yau P.W.P., Combined linked-unlinked total elbow arthroplasty: short-term results of 11 elbows, The 25th Annual Congress of Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2005, 9: S57.

Researcher : Zhao F

List of Research Outputs

Abbah S.A., Lu W.W., Cheung K.M.C., Zhao F., Chan D., Liu W.G., Li Z., Leong J.C.Y. and Luk K.D.K., Polymer encapsulated human osteoblastic cells form ectopic bone in mice, 52nd Annual Meeting of Orthopaedic Research Society, Chicago, Illinois, March 19-22, 2006.

Zhao F., Ma T. and Lu W.W., Effects of Hydroxyapatite on Excellular Matrix Organization of Human Mesenchymal Stem Cell within 3-D Hydroxyapatite / chitosan-gelatin Constructs, Annual Meeting - Biomaterials: The Enabling Technology. Pittsburgh, Pennsylvania, USA, April 26-29, 2006.

Zhao F., Grayson W.L., Ma T., Bunnell B. and Lu W.W., Effects of hydroxyapatitie in 3-D chitosan-gelatin polymer network on human mesenchymal stem cell construct development, Biomaterials. 2006, 27: 1859-1867.

Researcher : Zhu Y

List of Research Outputs

Ng T.P., Zhu Y. and Chiu P.K.Y., Cementless acetabular component inserted without screws: the effect of immediate weight-bearing, The 25th Annual Congress of Hong Kong Orthopaedic Association, Hong Kong Journal of Orthopaedic Surgery. 2005, 9: S56.

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