DEPT OF DIAGNOSTIC RADIOLOGY
| Researcher : Chau MT |
| List of Research Outputs |
| Tam K.F., Chau M.T., Chan Y.M., Ng T.Y., Wong R.L.C. and Ngan H.Y.S., Hepatic arteriogram for gestational trophoblastic tumor: Is it useful? , Cancer Investigation. 2005, 23: 677-682. |
| Researcher : Cheung SCW |
| List of Research Outputs |
| Cheung E.W.Y., Lam W.W.M., Chiu C.S.W., Chau A.K.T., Cheung S.C.W. and Cheung Y.F., Plasma Brain Natriuretic Peptide Levels, Right Ventricular Function and Exercise Capacity in Patients After Surgical Repair of Tetralogy of Fallot, 6th Guangdong-Hong Kong Paediatric Exchange Meeting, Guangdong, PRC, 25 June 2006. 54-55. |
| Cheung E.W.Y., Lam W.W.M., Chiu C.S.W., Chau A.K.T., Cheung S.C.W. and Cheung Y.F., Plasma Brain Natriuretic Peptide Levels, Right Ventricular Function and Exercise Capacity in Patients After Surgical Repair of Tetralogy of Fallot, Journal of the Hong Kong College of Cardiology, Including Abstracts of Fourteenth Annual Scientific Congress, Hong Kong College of Cardiology, Hong Kong, 5 -7 May 2006. 14(1): 48. |
| Cheung E.W.Y., Lam W.W.M., Cheung S.C.W. and Cheung Y.F., Relation of Right Ventricular Function by Cardiovascular Magnetic Resonance to Exercise Capacity in Patients After Repair of Tetralogy of Fallot, 6th Guangdong-Hong Kong Paediatric Exchange Meeting, Guangdong, PRC, 25 June 2006. 55-56. |
| Cheung E.W.Y., Lam W.W.M., Cheung S.C.W. and Cheung Y.F., Relation of Right Ventricular Function by Cardiovascular Magnetic Resonance to Exercise Capacity in Patients After Repair of Tetralogy of Fallot, Journal of the Hong Kong College of Cardiology, Including Abstracts of Fourteenth Annual Scientific Congress, Hong Kong College of Cardiology, Hong Kong, 5 -7 May 2006. 14(1): 46. |
| Researcher : Khong PL |
| Project Title: | To establish the use of magnetic resonance imaging for assessing the degree of brain damage following hypoxic ischemic insult with or without neuroprotective therapies |
| Investigator(s): | Khong PL, Cheung PT |
| Department: | Diagnostic Radiology |
| Source(s) of Funding: | Other Funding Scheme |
| Start Date: | 06/2002 |
| Abstract: |
| To evaluate the neuroprotective effects of one purified component of Traditional Chinese Medicine (TCM), caspase inhibitor (CI) and cyclosporin A (CA), in combination or alone. |
| Project Title: | Diffusion tensor MR imaging (DTI) for the detection and quantification of treatment-induced white matter injury in childhood tumours |
| Investigator(s): | Khong PL, Ooi CGC, Kwong DLW, Chan GCF |
| Department: | Diagnostic Radiology |
| Source(s) of Funding: | Competitive Earmarked Research Grants (CERG) |
| Start Date: | 11/2003 |
| Completion Date: | 10/2005 |
| Abstract: |
| To test the following hypotheses in acute lymphoblastic leukemia and childhood brain tumour survivors who have undergone cranial irradiation +/- chemotherapy: 1) Loss of anisotropy (i.e. reduction in FA) occurs in the white matter cranial irradiation and chemotherapy, and this is dose dependent; DTI is more sensitive for detection of treatment-induced white-matter injury compared to conventional MRI; White matter FA correlates with cognitive function; to determine if DTI is sensitive and accurate for detecting, quantifying and monitoring treatment-induced neurotoxicity. |
| Project Title: | Magnetic resonance imaging of neonatal rat brain to evaluate therapeutic interventions following hypoxic ischemic insult using a 1.5T clinical scanner and a custom made microimaging coil |
| Investigator(s): | Khong PL, Cheung PT, Ooi CGC, Shen GG |
| Department: | Diagnostic Radiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2003 |
| Completion Date: | 04/2006 |
| Abstract: |
| To evaluate the HIE induced changes by T1-weighted, T2-weighted and diffusion-weighted imaging, and to evaluate therapeutic interventions for neonatal hypoxic-ischaemic brain injuries, using the custom made animal micro-imaging coil (bird-cage coil). |
| Project Title: | Diffusion tensor MR imaging (DTI) for the detection and quantification of treatment-induced white matter injury in childhood tumours |
| Investigator(s): | Khong PL, Ooi CGC, Kwong DLW, Chan GCF |
| Department: | Diagnostic Radiology |
| Source(s) of Funding: | Merit Award for RGC CERG Funded Projects |
| Start Date: | 11/2003 |
| Completion Date: | 10/2005 |
| Abstract: |
| N/A |
| Project Title: | Diffusion tensor MRI assessment of the brain in low birth weight preterm children |
| Investigator(s): | Khong PL, Ooi CGC |
| Department: | Diagnostic Radiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2004 |
| Completion Date: | 01/2006 |
| Abstract: |
| To study the FA of the white matter in the brain by DTI, comparing with normal age-matched controls. |
| Project Title: | Whole body magnetic resonance (MR) screening in primary plasmacytomas |
| Investigator(s): | Khong PL, Chim JCS |
| Department: | Diagnostic Radiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2004 |
| Abstract: |
| To evaluate the clinical utility of whole body MR screening to detect occult lesions in the diagnostic work-up of cases with primary plasmacytomas, including primary solitary bone and extramedullary plasmacytomas. |
| Project Title: | Mapping dose distribution on the Fractional Anisotropy Map: Applications in the assessment of treatment-induced white matter injury |
| Investigator(s): | Khong PL, Kwong DLW, Chan GCF |
| Department: | Diagnostic Radiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 10/2005 |
| Abstract: |
| Treatment-induced neurotoxicity is prevalant and impacts significantly on the lives of childhood brain tumour survivors (Mulhern et al., 2004). Whole brain radiotherapy is considered to be the major contributory factor that causes these deficits (Johnson et al., 1994; Mulhern et al., 1998; Silber et al., 1992). It has been shown that white matter is predisposed to radiation-induced injury and that it may be the substrate of neurocognitive deterioration. There is emerging evidence that diffusion tensor MR imaging (DTI), using fractional anisotropy (FA), is sensitive in detecting and monitoring white matter injury in these patients. (Khong et al., 2005b; Khong et al., 2003; Khong et al., 2005a; Leung et al., 2004b). We aim to explore and describe an optimal method to map whole brain radiation dose distribution to the FA images of childhood brain tumour survivors. |
| List of Research Outputs |
| Au W.Y., Cheung W.C., Hu H.C., Chan G.C.F., Ha S.Y., Khong P.L., Ma E.S.K. and Liang R.H.S., Hyperbilirubinaemia and cholelithiasis in Chinese patients with hemoglobin H disease., Annals of Hematology. 2005, 84(10): 671-674. |
| Babyn P.S., Chu W.C., Tsou I.Y., Wansaicheong G.K., Allen U., Bitnun A., Chee T.S., Cheng F.W., Chiu M.C., Fok T.F., Hon E.K., Gahunia H.K., Kaw G.J., Khong P.L., Leung C.W., Li A.M., Manson D., Metreweli C., Ng P.C., Read S. and Stringer D.A., Severe acute respiratory syndrome (SARS): chest radiographic features in children, Walter Berdon Award for the Best Clinical Paper submitted to Journal of Pediatric Radiology, 2005. Pediatric Radiology. 2005, 34: 47-58. |
| Chung B.H.Y., Ip P., Wong V.C.N., Lo J., Nicholls J.M. and Khong P.L., Acute fulminant SSPE with absent measels and PCR studies in cerebrospinal fluid, DK 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, 16-17 September 2005. |
| Chung B.H.Y., Ma E.S.K., Khong P.L. and Chan G.C.F., Genetic thrombophilic risk factors in Chinese children with malignant illness, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 66. |
| Chung B.H.Y., Ma E.S.K., Khong P.L. and Chan G.C.F., Inherited Thrombophilia Does Not Increase Catheter Thrombosis in Chinese Children with malignancies, 1st Congress of Asian Society for Pediatric Research, Tokyo, Japan, 24-26 November 2005. 82. |
| Ho P.L., Chau P.H., Yip P.S.F., Ooi C.G.C., Khong P.L., Ho J.C.M., Wong P.C., Ko C.F., Yan C.P.K. and Tsang K.W.T., A prediction rule for clinical diagnosis of severe acute respiratory syndrome, European Respiratory Journal. 2005, 26(3): 474-9. |
| Khong P.L., Best Poster Award at Annual Scientific Meeting, Hong Kong College of Radiologists . 2005. |
| Khong P.L., Diffusion tensor MR imaging in paediatric neuroradiology., Joint Scientific Meeting of the RCR and HKCR and 13th Annual Scientific Meeting of Hong Kong College of Radiologists, Hong Kong, 21-23 October 2005.. 2005. |
| Khong P.L., Diffusion tensor MR imaging of intrinsic brain tumours, Commissioned Training in Neurorsurgery, Hospital Authority, Hong Kong Neurosurgical Society and University of Hong Kong Medical Center, Hong Kong, 12-14 January 2006. 2006. |
| Khong P.L., Editorial Board, The Chinese Journal of Medicine. 2005. |
| Khong P.L., Imaging the pediatric patient: specific pathologies-specific imaging protocols, 14th Scientific Meeting & Exhibition of the International Society of Magnetic Resonance Imaging in Medicine (ISMRM), Seattle, U.S.A., 6-12 May 2006. 2006. |
| Khong P.L., Journal of Pediatric Gastroenterology and Nutrition, Journal Reviewer. 2006. |
| Khong P.L., Wang Y., Qiu D., Shen G.G., Wu E.X. and Cheung P.T., MRI for the prediction of irreversible infarct size in neonatal rat brain after hypoxic-ischemic injury, Society of Paediatric Radiology and European Society of Paediatric Radiology's Fifth Conjoint Meeting, Montreal, Canada, 18-20 May 2006. |
| Khong P.L., Paediatric Emergency Radiology, Dedicated CME Programme for Non-Fellow 2005 organized by Hong Kong Academy of Medicine at Ruttonjee Hospital, Hong Kong, 7 July 2005. . 2005. |
| Khong P.L., Paediatric Emergency Radiology, Dedicated CME Programme for Non-Fellow 2006 organized by Hong Kong Academy of Medicine at Queen Elizabeth Hospital, Hong Kong, 19 April 2006. 2006. |
| Khong P.L., Pediatric Radiology, Editorial Board & Journal Reviewer. 2006. |
| Khong P.L., Pediatric Research, Journal Reviewer. 2006. |
| Khong P.L., Qiu D., Yung A.W.Y., Poon G.W.K., Leung C. and Lam B.C.C., Regional white matter anisotropy and general intelligence in preterm born children: a voxelwise analysis, 14th Scientific Meeting & Exhibition, Seattle, Washington, USA, 6-12 May 2006. |
| Khong P.L., The Hong Kong Journal of Paediatrics, Journal Reviewer. 2006. |
| Khong P.L., The Hong Kong Medical Journal, Journal Reviewer. 2006. |
| Khong P.L., The Journal of the Hong Kong College of Radiologists, Journal Associate Editor & Journal Reviewer. 2005. |
| Khong P.L., Leung L.H.T., Fung A.S.M., Fong D.Y.T., Qiu D., Kwong D.L.W., Ooi C.G.C., McAlonan G.M., Cao G. and Chan G.C.F., White Matter Anisotropy in Post-Treatment Childhood Cancer Survivors: Preliminary Evidence of Association With Neurocognitive Function, Journal of Clinical Oncology. 2006, 24(6): 884-890. |
| Khong P.L., Qiu D., Yung A.W.Y., Poon G.W.K., Leung C., Chua S.E., McAlonan G.M. and Lam B.C.C., White matter volume and anisotropy in very low birth weight preterm born children: association with cognitive outcome, 14th Scientific Meeting & Exhibition, Seattle, Washington, USA, 6-12 May 2006. |
| Leung C., Goh W.H.S., Khong P.L. and Wong V.C.N., Thalamic T2 hyperintensities and cognitive function in Chinese children with neurofibromatosis, Type I, DK 50th Anniversary Symposium on Paediatric Neuroloyg and Neuro-rehabilitation (Hong Kong, 16-17 September, 2005). 2005. |
| Ma I. and Khong P.L., Tracheobronchial foreign bodies: computed tomography appearances, Joint Scientific Meeting of the RCR and HKCR and 13th Annual Scientific meeting of HKCR, Hong Kong, 21-23 October 2005. |
| Ooi C.G.C., Chim J.C.S., Au W.Y. and Khong P.L., Radiologic Manifestations of Primary Solitary Extramedullary and Multiple Solitary Plasmacytomas , AJR. American journal of roentgenology. 2006, 186(3): 821-7. |
| Qiu D., Leung L., Kwong D.L.W., Chan G.L.H., Cao G. and Khong P.L., Discrepant FA reduction between the frontal and parietal lobes of post irradiation medulloblastoma survivors: preliminary findings of regional susceptibility?, ISMRM 14th Scientific Meeting & Exhibition, Seattle, Washington, U.S.A., 6-12 May 2006. |
| Qiu D., Leung L., Kwong D.L.W., Chan G.L.H., Cao G. and Khong P.L., Mapping radiation dose distribution on the Fractional Anisotropy Map: application in the assessment of treatment-induced white matter injury, ISMRM 14th Scientific Meeting & Exhibition, Seattle, Washington, U.S.A., 6-12 May 2006. |
| Qiu D., Leung L.H.T., Kwong D.L.W., Chan G.C.F. and Khong P.L., Mapping radiation dose distribution on the Fractional Anisotropy Map: application in the assessment of treatment-induced white matter injury, NeuroImage. 2006, 31: 109-115. |
| To R.W.Y., Lee S.L., Khong P.L., Goh W.H.S., Ip P., Wong V.C.N. and Wong W.H.S., Clinical evaluation by videofluoroscopic observaton on swallowing problems in children with neuromuscular diseases, DK 50th Anniversary symposium on Paediatric Neurology and Neuro-rehabilitation. 2005. |
| Wang Y., Cheung P.T., Shen G.G., Wu E.X., Cao G., Bhatia I., Wong W.H.S. and Khong P.L., Hypoxic-ischemic brain injury in the neonatal rat model: relationship between lesion size at early MR imaging and irreversible infarction, American Journal of Neuroradiology. 2006, 27: 51-54. |
| Wong V.C.N. and Khong P.L., Tuberous Sclerosis Complex: Correlation of Magnetic Resonance Imaging (MRI) Findings with Comorbidities, Journal of Child Neurology. 2006, 21(2): 99-105. |
| Yung A.W.Y., Leung C., Sze A., Khong P.L., Ho W.Y., Yuen S.M. and Fan Y.W., Clinical outcome in four patients after epilepsy surgery, The 50th Anniversary Symposium on Paediatric Neurology and Neuro-Rehabilitation, Children's Habilitation Institute, 16-17 September 2005. 49. |
| Yung A.W.Y., Poon G.W.K., Qiu D., Chu J., Leung C., Lam B.C.C., Goh W.H.S. and Khong P.L., White matter volume and anisotropy in preterm children: a pilot study of neurocognitive correlates, 1st Congress of the Asian Society for Pediatric Research (ASPR), Tokyo, Japan, 24-26 November 2005. |
| Researcher : Lam WWM |
| List of Research Outputs |
| Cheung E.W.Y., Lam W.W.M. and Cheung Y.F., Cardiovascular magnetic resonance imaging derived right ventricular volume and pulmonary regurgitant fraction relate to exercise capacity in patients after surgical repair of tetralogy of fallot, Joint Annual Scientific Meeting, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association, Queen Elizabeth Hospital, 7 January 2006. 70. |
| Cheung E.W.Y., Lam W.W.M., Chiu C.S.W., Chau A.K.T., Cheung S.C.W. and Cheung Y.F., Plasma Brain Natriuretic Peptide Levels, Right Ventricular Function and Exercise Capacity in Patients After Surgical Repair of Tetralogy of Fallot, 6th Guangdong-Hong Kong Paediatric Exchange Meeting, Guangdong, PRC, 25 June 2006. 54-55. |
| Cheung E.W.Y., Lam W.W.M., Chiu C.S.W., Chau A.K.T., Cheung S.C.W. and Cheung Y.F., Plasma Brain Natriuretic Peptide Levels, Right Ventricular Function and Exercise Capacity in Patients After Surgical Repair of Tetralogy of Fallot, Journal of the Hong Kong College of Cardiology, Including Abstracts of Fourteenth Annual Scientific Congress, Hong Kong College of Cardiology, Hong Kong, 5 -7 May 2006. 14(1): 48. |
| Cheung E.W.Y., Lam W.W.M., Cheung S.C.W. and Cheung Y.F., Relation of Right Ventricular Function by Cardiovascular Magnetic Resonance to Exercise Capacity in Patients After Repair of Tetralogy of Fallot, 6th Guangdong-Hong Kong Paediatric Exchange Meeting, Guangdong, PRC, 25 June 2006. 55-56. |
| Cheung E.W.Y., Lam W.W.M., Cheung S.C.W. and Cheung Y.F., Relation of Right Ventricular Function by Cardiovascular Magnetic Resonance to Exercise Capacity in Patients After Repair of Tetralogy of Fallot, Journal of the Hong Kong College of Cardiology, Including Abstracts of Fourteenth Annual Scientific Congress, Hong Kong College of Cardiology, Hong Kong, 5 -7 May 2006. 14(1): 46. |
| Researcher : Li G |
| Project Title: | The Neuroprotective Effect of Coenzyme Q10 in AD mice model |
| Investigator(s): | Li G, Yang ES, Yang YiHong, Jack Jr. Clifford |
| Department: | Medical Faculty |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 03/2006 |
| Abstract: |
| Alzheimer's disease (AD) and ischemic cerebrovascular disease are two main causes of dementia in elderly people. Recent basic and clinical investigations demonstrate that AD and vascular dementia (VaD), traditionally considered two independent neurological disorders, may interact in an additive manner. In clinical studies, the presence of ischemic lesions enhances the cognitive deficits in patients with AD pathology. Mutations in the genes of beta-amyloid precursor protein (APP), presenilin 1 (PS1) and presenilin 2 (PS2) cause familial AD. In transgenic mice with overexpressed APP, susceptibility to ischemic brain damage caused by middle cerebral artery occlusion (MCAO) is increased. In AD patients, the extent of AD pathology is increased if ischemic stroke coexists. Elderly subjects are more likely to have been demented in life if both AD pathology and ischemic cerebrovascular disease are present at autopsy than if either is pathology is found in isolation. Several studies suggest a possible role of increased oxidative stress and impairment of mitochondrial energy metabolism in the pathogenesis of both AD and stroke. A number of investigators have identified a deficiency in the complex VI, cytochrome c oxidase (COX) of the mitochondrial electron transport chain in AD patients and a reduced activity of complexes I and III in ischemic conditions. Coenzyme Q10 (CoQ10) is an essential biological cofactor produced endogenously in the body and provided in the food chain. As the electron acceptor for mitochondrial complexes I and II, it has an essential role in cellular energy production as an electron and proton carrier. Complex I or II dysfunction are found in neurological disorders such as Parkinson’s disease and Huntington disease. Shults et al. reported a correlation between mitochondrial CoQ10 level and the biological activity of complexes I - IV Parkinson’s disease patients who were administered the highest dose of CoQ10 showed the greatest clinical benefit. Oral CoQ10 supplementation increases brain mitochondrial concentrations and exerts neuroprotective effects. A neuroprotective effect of CoQ10 has been found in various animal models of stroke and this has been attributed to its role as a potent antioxidant and an oxygen derived free radical scavenger. This finding has not been universally replicated, however, as Li and his colleagues found that immediate treatment with CoQ10 via intraperitoneal injection did not prevent neuronal injuries following global and focal ischemia. Mitochondrial abnormalities have been found in human AD patients, and there are a few reports about the therapeutic effect of CoQ10 in AD patients. Results have been mixed however, for example, de Bustos et al. investigated serum levels of CoQ10 in patients with AD and found no relationship with the risk of AD and vascular dementia. CoQ10 has been shown to have a neuroprotective effect in other neurodegenerative diseases, such as Parkinson’s and Huntington’s diseases. In this study, we address the effects of CoQ10 on AD and cerebral ischemia using volume magnetic resonance imaging (MRI) in transgenic animal models. APP/PS1, APP and PS1 transgenic mice with ischemic stroke will be treated with high-dose CoQ10 for 28 days, and then their brain specimens will be examined by MRI to investigate the neuroprotective effects of CoQ10, compared to the non-treated counterparts. Transgenic rather than wild type mice will be employed in order to amplify the destructive effects of stroke in the experimental animals. |
| List of Research Outputs |
| Researcher : Ooi CGC |
| Project Title: | Nasal T/NK-cell lymphoma: CT and MR imaging features of a new clinico-pathological entity: lethal midline granuloma reclassified |
| Investigator(s): | Ooi CGC, Liang RHS, Kwong YL, Chim JCS |
| Department: | Diagnostic Radiology |
| Source(s) of Funding: | Other Funding Scheme |
| Start Date: | 06/1999 |
| Abstract: |
| To describe the radiological features with respect to computed tomography (CT) and magnetic resonance imaging (MRI) of nasal T/NK cell lymphoma; to devise a local (T) tumour staging system and evaluate any correlation with survival and prognosis. |
| Project Title: | Computed tomography (CT) characterization of irreversible asthma with morphologic functional correlation |
| Investigator(s): | Ooi CGC, Ip MSM, Khong PL |
| Department: | Diagnostic Radiology |
| Source(s) of Funding: | Low Budget High Impact Programme |
| Start Date: | 11/2001 |
| Abstract: |
| To characterize CT features of irreversible or end stage asthma; to develop a scoring system to quantify these changes on CT; to correlate lung function with CT score of lung changes; to evaluate whether small airways disease seen on CT is an association of end-stage asthma; to evaluate the significance of bronchial wall thickening in this condition. |
| Project Title: | Prognostic significance of CT-derived tumour volume in oesophageal cancer |
| Investigator(s): | Ooi CGC, Khong PL |
| Department: | Diagnostic Radiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2002 |
| Abstract: |
| To quantify baseline and post chemo-irradiation (post-treatment) tumour volumes (TV) in patients with oesophageal carcinoma using computed tomography (CT); to quantify post-treatment TV based on PET (positron emission tomography)/CT data; to evaluate the relationships between baseline and post-treatment TV, with T-stage, N-stage, overall stage and survival; to evaluate the relationship between SUV (standardised uptake value) uptake in PET and TV; to determine the significance of baseline and post-treatment CT-TV on changes in T and N stage after chemo-irradiation. |
| Project Title: | Clinical utility of radiological assessment of Severe Acute Respiratory Syndrome: a retrospective and prospective study on a cohort of SARS patients |
| Investigator(s): | Ooi CGC, Tsang KWT, Khong PL |
| Department: | Diagnostic Radiology |
| Source(s) of Funding: | VCO SARS Research Fund |
| Start Date: | 07/2003 |
| Abstract: |
| To quantify severity of severe acute respiratory syndrome (SARS) on chest radiograph and to determine its relationship with clinical parameters; to evaluate the predictive value of chest radiographs on oxygen supplementation requirement and treatment response in severe acute respiratory syndrome (SARS); to document serial lung changes on HRCT int he acute and covalescent period; to document and describe irreversible lung changes of HRCT on long term follow-up. |
| Project Title: | HRCT quantification of lung disease in SARS: correlation with clinical parameters and residual disease |
| Investigator(s): | Ooi CGC, Tsang KWT, Khong PL |
| Department: | Diagnostic Radiology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2003 |
| Abstract: |
| To validate a commercially available quantitative technique in measuring normal lung volume and volume of lung abnormalities on high resolution CT (HRCT) scans; to correlate disease volume measured on HRCT at or near maximal lung disease as defined on chest radiograph in SARS with clinical parameters such as exercise tolerance, and amount of residual disease 6 months after discharge. |
| List of Research Outputs |
| Chan J.C.W., Chim J.C.S., Ooi C.G.C., Cheung B.M.Y., Liang R.H.S., Chan T.K. and Chan V.N.Y., Use of the oral chelator deferiprone in the treatment of iron overload in patients with Hb H disease, British Journal of Haematology. 2006, 133(2): 198-205. |
| Chan V.N.Y., Chan J.C.W., Chim J.C.S., Ooi C.G.C., Cheung B.M.Y., Liang R.H.S. and Chan T.K., Deferiprone in the treatment of iron overload in patients with Hb H disease, XXXth World Congress of the International Society of Hematology, Istanbul, Turkey. Istanbul, Turkey, 2005. |
| Chim J.C.S. and Ooi C.G.C., Bulbar palsy in multiple myeloma, Haematologica. 2005, 90(12Suppl): ECF42. |
| Chim J.C.S., Yuen W.K., Loong F., Hu H.C. and Ooi C.G.C., Primary large B-cell lymphoma of the ampulla of vater, Haematologica. 2006, 91(3): ECR06. |
| Ho P.L., Chau P.H., Yip P.S.F., Ooi C.G.C., Khong P.L., Ho J.C.M., Wong P.C., Ko C.F., Yan C.P.K. and Tsang K.W.T., A prediction rule for clinical diagnosis of severe acute respiratory syndrome, European Respiratory Journal. 2005, 26(3): 474-9. |
| Khong P.L., Leung L.H.T., Fung A.S.M., Fong D.Y.T., Qiu D., Kwong D.L.W., Ooi C.G.C., McAlonan G.M., Cao G. and Chan G.C.F., White Matter Anisotropy in Post-Treatment Childhood Cancer Survivors: Preliminary Evidence of Association With Neurocognitive Function, Journal of Clinical Oncology. 2006, 24(6): 884-890. |
| Kwok R.P., Sun J.Z., Tipoe G.L., Leung Y.H., Yan C.P.K., Ooi C.G.C., Ho P.L., Mak J.C.W., Lam W.K. and Tsang K.W.T., Pseudomonas aeruginosa pyocyanin : discruption of ultrastructure of human respiratory mucosa in vitro, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong,. 2006, Abstract Book 087: pp. 55. |
| Kwok R.P., Sun J.Z., Tipoe G.L., Leung Y.H., Yan C.P.K., Ooi C.G.C., Ho P.L., Mak J.C.W., Lam W.K. and Tsang K.W.T., Pseudomonas aeruginosa pyocyanin : discruption of ultrastructure of human respiratory mucosa in vitro, Respirology. 2005, 10 (Suppl): A126 (#170). |
| Kwok R.P., Leung Y.H., Sun J.Z., Yan C.P.K., Ooi C.G.C., Ho P.L., Tipoe G.L., Lam W.K. and Tsang K.W.T., The effects of gelomyrtol ForteÒ on human ciliary beat frequency in bronchiectasis subjects in vitro, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2006, Abstract Book 086: pp.54. |
| Kwok R.P., Leung Y.H., Sun J.Z., Yan C.P.K., Ooi C.G.C., Ho P.L., Tipoe G.L., Lam W.K. and Tsang K.W.T., The effects of gelomyrtol forteÒ on human ciliary beat frequency in bronchiectasis subjects in vitro, Respirology. 2005, 10 (Suppl): A126 (#169). |
| Kwok R.P., Leung Y.H., Sun J.Z., Yan C.P.K., Ko K.W., Ooi C.G.C., Ho P.L., Tipoe G.L., Lam W.K. and Tsang K.W.T., The effects of myrtol standardized on human ciliary beat frequency in vitro, European Respiratory Medicine. 2005, 26 (Suppl 49): 100S (#714). |
| Lam B., Tam C.M., Lam S.Y., Wong M.P., Ooi C.G.C., Fung S.L., Lam D.C.L., Ip M.S.M. and Lam W.K., Detection of early lung cancer in high risk population: A prospective study. 11th World Conference on Lung Cancer, Lung Cancer. 2005, 49 (Suppl 2): S182 (P-257). |
| Lam B., Wong M.P., Fung S.L., Lam D.C.L., Wong P.C., Mok T.Y.W., Lam F.M., Ip M.S.M., Ooi C.G.C. and Lam W.K., The clinical value of autofluorescence bronchoscopy for the diagnosis of lung cancer, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong. 2006, Abstract Book 094: pp. 58. |
| Mak J.C.W., Ho S.P., Leung Y.H., Ho P.L., Ooi C.G.C., Tipoe G.L., Yan C.P.K., Ip M.S.M., Lam W.K. and Tsang K.W.T., Elevated levels of transforming growth factor-beta(1) in serum of patients with stable bronchiectasis, Respiratory Medicine. 2005, 99: 1223-1228. |
| Ooi C.G.C., Chest Imaging Session : MDCT in imaging thoracic diseases., International Imaging Course 2005. Department of Diagnostic Radiology and Organ Imaging, Faculty of Medicine, The Chinese University of Hong Kong. September 24-25, 2005.. 2005. |
| Ooi C.G.C., Chim J.C.S., Au W.Y. and Khong P.L., Radiologic Manifestations of Primary Solitary Extramedullary and Multiple Solitary Plasmacytomas , AJR. American journal of roentgenology. 2006, 186(3): 821-7. |
| Ooi C.G.C., Ho J.C.M., Lam B., Lai A.Y.K., Tsang K.W.T. and Lam W.K., Relationship between MR intra-abdominal fat parameters and cardiovascular risk parameters in obstructive sleep apnoea, Respirology. 2005, 10 (Suppl): A176 (#366). |
| Ooi C.G.C., Survey of solitary pulmonary nodule., The 10th Congress of the Asian Pacific Society of Respirology 11-14 November 2005, Guangzhou, China.. 2005. |
| Sam K., Lam B., Ooi C.G.C., Cooke M.S. and Ip M.S.M., Effect of a fixed oral appliance on upper airway morphology in obstructive sleep apnea, 11th Medical Research Conference, Department of Medicine, The University of Hong Kong, January 2006. Abstract Book 095: pp.59. |
| Sam K., Lam B., Ooi C.G.C., Cooke M.S. and Ip M.S.M., Effect of a non-adjustable oral appliance on upper airway morphology in obstructive sleep apnea, Respiratory Medicine. 2006, 100: 897-902. |
| Tse E.W.C., Yip S.F., Ooi C.G.C. and Kwong Y.L., Subarachnoid haemorrhage: more than meets the eye, British Journal of Haematology. 2006, 132(4): 383. |
| Researcher : Qiu D |
| List of Research Outputs |
| Khong P.L., Wang Y., Qiu D., Shen G.G., Wu E.X. and Cheung P.T., MRI for the prediction of irreversible infarct size in neonatal rat brain after hypoxic-ischemic injury, Society of Paediatric Radiology and European Society of Paediatric Radiology's Fifth Conjoint Meeting, Montreal, Canada, 18-20 May 2006. |
| Khong P.L., Qiu D., Yung A.W.Y., Poon G.W.K., Leung C. and Lam B.C.C., Regional white matter anisotropy and general intelligence in preterm born children: a voxelwise analysis, 14th Scientific Meeting & Exhibition, Seattle, Washington, USA, 6-12 May 2006. |
| Khong P.L., Qiu D., Yung A.W.Y., Poon G.W.K., Leung C., Chua S.E., McAlonan G.M. and Lam B.C.C., White matter volume and anisotropy in very low birth weight preterm born children: association with cognitive outcome, 14th Scientific Meeting & Exhibition, Seattle, Washington, USA, 6-12 May 2006. |
| Qiu D., Leung L., Kwong D.L.W., Chan G.L.H., Cao G. and Khong P.L., Discrepant FA reduction between the frontal and parietal lobes of post irradiation medulloblastoma survivors: preliminary findings of regional susceptibility?, ISMRM 14th Scientific Meeting & Exhibition, Seattle, Washington, U.S.A., 6-12 May 2006. |
| Qiu D., Leung L., Kwong D.L.W., Chan G.L.H., Cao G. and Khong P.L., Mapping radiation dose distribution on the Fractional Anisotropy Map: application in the assessment of treatment-induced white matter injury, ISMRM 14th Scientific Meeting & Exhibition, Seattle, Washington, U.S.A., 6-12 May 2006. |
| Qiu D., Leung L.H.T., Kwong D.L.W., Chan G.C.F. and Khong P.L., Mapping radiation dose distribution on the Fractional Anisotropy Map: application in the assessment of treatment-induced white matter injury, NeuroImage. 2006, 31: 109-115. |
| Yung A.W.Y., Poon G.W.K., Qiu D., Chu J., Leung C., Lam B.C.C., Goh W.H.S. and Khong P.L., White matter volume and anisotropy in preterm children: a pilot study of neurocognitive correlates, 1st Congress of the Asian Society for Pediatric Research (ASPR), Tokyo, Japan, 24-26 November 2005. |
| Researcher : Tso WK |
| List of Research Outputs |
| Liem M.S.L., Poon R.T.P., Lo C.M., Tso W.K. and Fan S.T., Outcome of transarterial chemoembolization in patients with inoperable hepatocellular carcinoma eligible for radiofrequency ablation, World Journal of Gastroenterology. 2005, 11(29): 4465-4471. |
| Liem M.S.L., Liu C.L., Tso W.K., Lo C.M., Fan S.T. and Wong J., Portal vein embolisation prior to extended right-sided hepatic resection, Hong Kong Medical Journal. 2005, 11(5): 366-372. |
| Liu C.L., Fan S.T., Lo C.M., Tso W.K., Wong Y., Poon R.T.P., Lam C.M., Wong B.C.Y. and Wong J., Clinicobiochemical prediction of biliary cause of acute pancreatitis in the era of endoscopic ultrasonography, Alimentary Pharmacology and Therapeutics. 2005, 22(5): 423-431. |
| Liu C.L., Fan S.T., Lo C.M., Tso W.K., Wong Y., Poon R.T.P., Lam C.M., Wong B.C.Y. and Wong J., Comparison of early endoscopic ultrasonography and endoscopic retrograde cholangiopancreatography in the management of acute biliary pancreatitis: a prospective randomized study, Clinical Gastroenterology and Hepatology. 2005, 3(12): 1238-1244. |
| Ng K.K.C., Poon R.T.P., Chan F.S.Y., Yuen J.H.F., Tso W.K. and Fan S.T., Comparison of radiofrequency ablation and hepatic re-resection for intrahepatic recurrent hepatocellular carcinoma (Oral Presentation), The 106th Annual Congress of Japan Surgical Society, Tokyo, Japan, 29-31 March 2006. |
| Ng K.K.C., Poon R.T.P., Lam C.M., Yuen J.H.F., Tso W.K. and Fan S.T., Efficacy and safety of radiofrequency ablation for perivascular hepatocellular carcinoma without hepatic inflow occlusion, British Journal of Surgery. 2006, 93(4): 440-447. |
| Ng K.K.C., Poon R.T.P., Lo C.M., Yuen J.H.F., Tso W.K. and Fan S.T., Recurrence pattern and survival outcome after radiofrequency ablation of hepatocellular carcinoma (Abstract), The 16th World Congress of the International Association of Surgeons and Gastroenterologists, Madrid, Spain, 25 - 27 May 2006. |
| Researcher : Wang Y |
| List of Research Outputs |
| Khong P.L., Wang Y., Qiu D., Shen G.G., Wu E.X. and Cheung P.T., MRI for the prediction of irreversible infarct size in neonatal rat brain after hypoxic-ischemic injury, Society of Paediatric Radiology and European Society of Paediatric Radiology's Fifth Conjoint Meeting, Montreal, Canada, 18-20 May 2006. |
| Wang Y., Cheung P.T., Shen G.G., Wu E.X., Cao G., Bhatia I., Wong W.H.S. and Khong P.L., Hypoxic-ischemic brain injury in the neonatal rat model: relationship between lesion size at early MR imaging and irreversible infarction, American Journal of Neuroradiology. 2006, 27: 51-54. |
| Researcher : Wong Y |
| List of Research Outputs |
| Chan S.C., Liu C.L., Lo C.M., Lam B.K.Y., Lee E.W.M., Wong Y. and Fan S.T., Estimating liver weight of adults by body weight and gender, World Journal of Gastroenterology. 2006, 12(14): 2217-2222. |
| Chan S.C., Lo C.M., Wong Y., Liu C.L. and Fan S.T., Long-term biological consequences of donor right hepatectomy including the middle hepatic vein in adult-to-adult live donor liver transplantation, Liver Transplantation. 2006, 12(2): 259-263. |
| Chan S.C., Lo C.M., Liu C.L., Wong Y. and Fan S.T., Versatility and viability of hepatic venoplasty in live donor liver transplantation using the right lobe with the middle hepatic vein, Hepatobiliary and Pancreatic Diseases International. 2005, 4(4): 618-621. |
| Liu C.L., Fan S.T., Lo C.M., Tso W.K., Wong Y., Poon R.T.P., Lam C.M., Wong B.C.Y. and Wong J., Clinicobiochemical prediction of biliary cause of acute pancreatitis in the era of endoscopic ultrasonography, Alimentary Pharmacology and Therapeutics. 2005, 22(5): 423-431. |
| Liu C.L., Fan S.T., Lo C.M., Tso W.K., Wong Y., Poon R.T.P., Lam C.M., Wong B.C.Y. and Wong J., Comparison of early endoscopic ultrasonography and endoscopic retrograde cholangiopancreatography in the management of acute biliary pancreatitis: a prospective randomized study, Clinical Gastroenterology and Hepatology. 2005, 3(12): 1238-1244. |
| Researcher : Wu EX |
| Project Title: | Magnetic resonance imaging for biomedical research |
| Investigator(s): | Wu EX |
| Department: | Engineering Faculty |
| Source(s) of Funding: | Seed Funding for New Staff |
| Start Date: | 02/2004 |
| Abstract: |
| To develop and acquire the basic and necessary software and hardware required for the MRI research at HKU. |
| Project Title: | Manganese-enhanced Magnetic Resonance Imaging of Rodent Brain Function and Pathology |
| Investigator(s): | Wu EX |
| Department: | Engineering Faculty |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 10/2005 |
| Abstract: |
| Manganese ions (Mn++) have been recently discovered as a Ca++ analog in neuronal transport that tracks various active neuronal pathways and cortical projections. The primary objective of this project is to explore and develop in vivo Mn-enhanced MRI (MEMRI) technology that is suitable for interrogation of rodent brain functions in normal and pathological states. The specific aims are to (1) establish an optimal high-resolution MEMRI protocol to detect neural activity in various regions of normal rodent brain; (2) define and characterize altered patterns of MEMRI enhancement associated with neonatal hypoxia ischemia in mouse model and glaucoma in rat model. |
| List of Research Outputs |
| Azeloglu E.U., Tang H., Chen R.K., Chaudhry H.W., Wu E.X., Gaudette G.R. and Costa K.D., Automated adaptive analysis of tagged magnetic resonance images of the mouse heart, 2006 Proceedings of International Society of Magnetic Resonance in Medicine. 2006, 1217. |
| Chang C., Mao X., Hung Y.S., Yang J., Fung P.C.W., Shungu D.C. and Wu E.X., Blind spectra decomposition of MRSI of the brain with tumor by sparse component analysis, 2006 Proceedings of International Society of Magnetic Resonance in Medicine. 2006, 2541. |
| Cheung J.S., Chow A.M., Hui E.S., Yang J., Tse H.F. and Wu E.X., Cell number quantification of USPIO-labeled stem cells by MRI: an in vitro study, 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS). 2006, 476. |
| Cheung S.C., Yang J., Hui S.K. and Wu E.X., MRI characterization of trabecular bone structure by exploring bone microscopic susceptibility effect, 2006 Proceedings of International Society of Magnetic Resonance in Medicine. 2006, 1699. |
| Hui S.K., Yang J., Cheung S.C. and Wu E.X., MOTSA TOF-MRA using multi-oblique-stacks acquisition (MOSA), 2006 Proceedings of International Society of Magnetic Resonance in Medicine. 2006, 1942. |
| Khong P.L., Wang Y., Qiu D., Shen G.G., Wu E.X. and Cheung P.T., MRI for the prediction of irreversible infarct size in neonatal rat brain after hypoxic-ischemic injury, Society of Paediatric Radiology and European Society of Paediatric Radiology's Fifth Conjoint Meeting, Montreal, Canada, 18-20 May 2006. |
| Ng M.C., Wu E.X., Lau H.F., Hu Y., Yang E.S. and Luk K.D.K., Detection of ipsilateral and contralateral activation components in unilateral fingers-tapping using spinal BOLD fMRI., Proc. 14th ISMRM; 2006. Seattle, U.S.A. |
| Tang H., Wu E.X., Kennan R. and Liu H., Gradient reversal technique revisited for simultaneous water and fat imaging at high field, 2006 Proceedings of International Society of Magnetic Resonance in Medicine. 2006, 627. |
| Tang H., Wu E.X. and Vasseli J.R., MRI and Image Quantitation for Drug Assessment - Growth Effects of Anabolic Steroids and Precursors, 27th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS). 2005, 3.1.3-1. |
| Tang H., Wu E.X. and Vasseli J.R., MRI and image quantitation for assessment of the growth effects of anabolic steroid precursors in a guinea pig model, 2006 Proceedings of International Society of Magnetic Resonance in Medicine. 2006, 1257. |
| Wang Y., Cheung P.T., Shen G.G., Wu E.X., Cao G., Bhatia I., Wong W.H.S. and Khong P.L., Hypoxic-ischemic brain injury in the neonatal rat model: relationship between lesion size at early MR imaging and irreversible infarction, American Journal of Neuroradiology. 2006, 27: 51-54. |
| Wong K., Wu E.X., Ng M.C., Wu Y., Tse H.F., Lau C.P., Lo G. and Yang E.S., Image Registration in Myocardial Perfusion MRI, 27th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS). 2005, 3.5.1-1. |
| Wu E.X., 2005 ISMRM (Internationall Society of Magnetic Resonance in Medicine) Scientific Reviewer. 2005. |
| Wu E.X., In: Session Chair of "MRI of Animal Models Other Than stroke", 2006 ISMRM (International Society of Magnetic Resonance in Medicine), Seattle, USA . Seattle, USA, 2006. |
| Wu E.X., Associate Editor for Biomedical Imaging and Image Processing Theme Track Chair for Magnetic Resonance Imaging Session Chair of “MRI: Novel Applications” , 2006 IEEE-EMBC (Engineering in Medicine and Biology Conference), New York, USA. 2006. |
| Wu E.X., Chair for Biomedical Imaging and Image Processing Theme Session Chair of “Novel MRI Instrumentation, Methods and Applications”Session Chair of “Molecular Imaging”, In: Editor for Biomedical Imaging and Image Processing Theme , 2005 IEEE-EMBC (Engineering in Medicine and Biology Conference), Shanghai, China. 2005. |
| Wu E.X., Hui S.K. and Yang J., Free-breathing 2D time-of-flight pulmonary MRA at 3T, Proceedings of International Society of Magnetic Resonance in Medicine. 2006, 1955. |
| Wu E.X., Tang H. and Vasselli J.R., Growth effects of anabolic steroids and precursors in animal model using quantitative and longitudinal MRI assessment, The Endocrine Society’s 88th Annual Meeting, Boston. 2006. |
| Wu E.X., High-field MRI study of animal models – technologies and applications, Workshop on Biomedical Engineering (invited lecture). 2006, 26. |
| Wu E.X., High-field MRI study of animal models – technologies and applications, Workshop on Biomedical Engineering (invited), Hong Kong. 2006, 26. |
| Wu E.X., International Journal Ad Hoc Reviewer, Circulation (Impact factor: 10.5). 2005. |
| Wu E.X., International Journal Ad Hoc Reviewer, IEEE Transactions on Biomedical Engineering (Impact factor: 1.5). 2005. |
| Wu E.X., International Journal Ad Hoc Reviewer, Journal of Magnetic Resonance Imaging (Impact factor: 2.4). 2005. |
| Wu E.X., International Journal Ad Hoc Reviewer, Magnetic Resonance in Medicine (Impact factor: 3.4). 2005. |
| Wu E.X., MRI technology and applications in orthopedic research (invited lecture), International Symposium on Quality of bone and Scaffold Biomaterials, Hong Kong. 2005. |
| Wu E.X., MRI technology – visualize living biology (invited lecture)., 13th Annual Conference of Hong Kong Institution of Science. 2005, 27. |
| Wu E.X., Molecular imaging of cancer – MRI, optical imaging, and biomarkers (invited lecture), 12th Hong Kong International Cancer Congress. 2005, 22. |
| Wu E.X., Organizing Committee Member, 2006 HKU Workshop on Biomedical Imaging, Hong Kong. 2006. |
| Wu Y., Tse H.F. and Wu E.X., Diffusion tensor MRI study of myocardium remodeling after infarction in porcine model, 29th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS). 2006, 1069. |
| Wu Y., Wu E.X., Wong K., Tang H., Tse H.F., Lau C.P. and Yang E.S., Myocardial Fiber Length Mapping with MR Diffusion Tensor Imaging, 27th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBS). 2005, 3.5.3-5. |
| Researcher : Yuen JHF |
| List of Research Outputs |
| Chan F.S.Y., Ng K.K.C., Poon R.T.P., Yuen J.H.F. and Fan S.T., Comparison of radiofrequency ablation and hepatic re-resection for intrahepatic recurrent hepatocellular carcinoma (Abstract), The 4th Japan Society of Hepatology Single Topic Conference, "Hepatocellular Carcinoma: International Consensus and Controversies", Awaiji Island, Hyogo, Japan, 2-3 December 2005. |
| Ng K.K.C., Poon R.T.P., Chan F.S.Y., Yuen J.H.F., Tso W.K. and Fan S.T., Comparison of radiofrequency ablation and hepatic re-resection for intrahepatic recurrent hepatocellular carcinoma (Oral Presentation), The 106th Annual Congress of Japan Surgical Society, Tokyo, Japan, 29-31 March 2006. |
| Ng K.K.C., Poon R.T.P., Lam C.M., Yuen J.H.F., Tso W.K. and Fan S.T., Efficacy and safety of radiofrequency ablation for perivascular hepatocellular carcinoma without hepatic inflow occlusion, British Journal of Surgery. 2006, 93(4): 440-447. |
| Ng K.K.C., Poon R.T.P., Lo C.M., Yuen J.H.F., Tso W.K. and Fan S.T., Recurrence pattern and survival outcome after radiofrequency ablation of hepatocellular carcinoma (Abstract), The 16th World Congress of the International Association of Surgeons and Gastroenterologists, Madrid, Spain, 25 - 27 May 2006. |