DEPT OF PSYCHIATRY



Researcher : Chan LS

List of Research Outputs

Chan L.S., Chen E.Y.H. and Chan R.C.K., Three-subtest Short Form of the Wechsler Adult Intelligence Scale-III for Patients with Psychotic Disorders: a Preliminary Report, Hong Kong Journal of Psychiatry. 2005, 15: 39-42.


Researcher : Chan RCK

List of Research Outputs

Chan L.S., Chen E.Y.H. and Chan R.C.K., Three-subtest Short Form of the Wechsler Adult Intelligence Scale-III for Patients with Psychotic Disorders: a Preliminary Report, Hong Kong Journal of Psychiatry. 2005, 15: 39-42.
Chan R.C.K., Chen E.Y.H. and Law C.W., Fractionating the executive function in schizophrenia: does it still hold true for medication-naïve sample? , Schizophrenia Research. 2006, 81: 230.
Chan R.C.K., Chen E.Y.H., Cheung E.F.C., Chen R.Y.L. and Cheung H.K., The components of executive functioning in a cohort of patients with chronic schizophrenia: a multiple single-case study design, Schizophrenia Research. 2006, 81(2-3): 173-189.
Chiang J.C.S., Chow A.S.Y., Chan R.C.K., Law C.W. and Chen E.Y.H., Pathway to Care for Patients with First-episode Psychosis in Hong Kong, Hong Kong Journal of Psychiatry. 2005, 15: 18-22.
Honer W.G., Thornton A.E., Chen E.Y.H., Chan R.C.K., Wong J.O.Y., Bergmann A., Falkai P., Pomarol-Clotet E., McKenna P.J., Stip E., Williams R., MacEwan G.W., Wasan K. and Procyshyn K., Clozapine alone versus clozapine and risperidone with refractory schizophrenia, New England Journal of Medicine. 2006, 354: 472-482.
Law C.W., Chen E.Y.H., Cheung E.F.C., Chan R.C.K., Wong J.G.W.S., Lam C.L.K., Leung K.F. and Lo M.S.M., Impact of Untreated Psychosis on Quality of Life in Patients with First-episode Schizophrenia, Quality of Life Research. 2005, 14: 1803-1811.


Researcher : Chan WF

List of Research Outputs

Chen E.Y.H., Hui L.M.C., Wong C.K., Dunn E.L.W., Chan W.F., Miao Y.K., Yeung W.S. and Tang O.W.N., Long duration of untreated psychosis is associated with poorer neurocognitive and negative symptom recovery after first episode schizophrenia, Schizophrenia Research. 2006, 81: 231.
Hui L.M.C., Chen E.Y.H., Wong C.K., Chan W.F. and Tang O.W.N., The course of semantic memory dysfunction in first-episode schizophrenia: a prospective 3-year longitudinal study, 13th Biennial Winter Workshop on Schizophrenia Research. Davos, 2006.
Hui L.M.C., Chen E.Y.H., Wong C.K., Dunn E.L.W., Chan W.F., Miao Y.K., Yeung W.S. and Tang O.W.N., The course of semantic memory dysfunction in first-episode schizophrenia, Schizophrenia Research. 2006, 81: 111.


Researcher : Chau WY

List of Research Outputs

Lee W.Y., Chen R.Y.L., Chum K.W.C., Chau W.Y., Lee A.M., Chen E.Y.H., Tang S.W. and Sham P.C., Psychiatric comorbidity of substance use disorder and pathological gambling in Hong Kong Chinese, Paper presented at the Australian National Association for Gambling Studies (January 2006). 2006.


Researcher : Chen EYH

Project Title:Outcome of an early intervention programme for psychosis (EASY): a case controlled study
Investigator(s):Chen EYH, Chan RCK
Department:Psychiatry
Source(s) of Funding:Health and Health Services Research Fund - Full Grants
Start Date:09/2005
Abstract:
The study will help identify the effectiveness of early intervention for psychosis in Hong Kong. In addition to a broad range of outcome asssessment, it will provide service utilization and functioning data for cost effectiveness evaluation. The study will also identify areas of unmet needs and provide guidance for future service development.


Project Title:Duration of maintenance anti-psychotic therapy after first-episode schizophrenia: a double-blind randomized placebo-control relapse prevention study
Investigator(s):Chen EYH
Department:Psychiatry
Source(s) of Funding:Merit Award for RGC CERG Funded Projects
Start Date:09/2005
Abstract:
N/A


Project Title:Duration of maintenance anti-psychotic therapy after first-episode schizophrenia: a double-blind randomized placebo-control relapse prevention study
Investigator(s):Chen EYH, Law CW, Hung SF, Tso S, Chung DWS, Chan KPM, Chiu CPY, Chan KT, Pang PF
Department:Psychiatry
Source(s) of Funding:Competitive Earmarked Research Grants (CERG)
Start Date:09/2005
Abstract:
To study the efficacy of relapse prevetion by maintenance antipsychotic therapy in patients who had responded well and remained well for 12 months following a first-episode schizophrenia.


List of Research Outputs

Chan L.S., Chen E.Y.H. and Chan R.C.K., Three-subtest Short Form of the Wechsler Adult Intelligence Scale-III for Patients with Psychotic Disorders: a Preliminary Report, Hong Kong Journal of Psychiatry. 2005, 15: 39-42.
Chan R.C.K., Chen E.Y.H. and Law C.W., Fractionating the executive function in schizophrenia: does it still hold true for medication-naïve sample? , Schizophrenia Research. 2006, 81: 230.
Chan R.C.K., Chen E.Y.H., Cheung E.F.C., Chen R.Y.L. and Cheung H.K., The components of executive functioning in a cohort of patients with chronic schizophrenia: a multiple single-case study design, Schizophrenia Research. 2006, 81(2-3): 173-189.
Chen E.Y.H., Chief Editor, The Hong Kong Journal of Psychiatry. 2005.
Chen E.Y.H., Early Psychosis in an Asian urban setting: critical issues and research, Harvard Initiative in Global Mental Health. Boston, Harvard Medical School, 2006.
Chen E.Y.H., Editorial Board (2003-present), Schizophrenia Research. 2006.
Chen E.Y.H., Editorial Board (2005-present), Chinese Medical Journal . 2005.
Chen E.Y.H., Improving the service for early psychosis in an Asian context: the Hong Kong experience, The 9th annual meeting, Japanese Society of Prevention in Psychiatric Disorders. Japanese Society of Prevention in Psychiatric Disorders, Tokyo, 2005.
Chen E.Y.H., Issues in early intervention and recovery from first-episode psychosis, Keio Medical Society Lecture series. Keio University, Tokyo, 2005.
Chen E.Y.H., Hui L.M.C., Wong C.K., Dunn E.L.W., Chan W.F., Miao Y.K., Yeung W.S. and Tang O.W.N., Long duration of untreated psychosis is associated with poorer neurocognitive and negative symptom recovery after first episode schizophrenia, Schizophrenia Research. 2006, 81: 231.
Chen E.Y.H., Member (2000-present), International Early Psychosis Association. 2006.
Chen E.Y.H., Member (2003-present), VALID study international steering committee. 2006.
Chen E.Y.H., President (2004-present), Asian Network for Early Psychosis. 2006.
Chen E.Y.H., Chan W.S.C., Wong P.W.C., Chan S.S.M., Chan C.L.W. and Law Y.W., Suicide in Hong Kong: a case-control psychological autopsy study, Psychological Medicine. 2006, 36(6): 815-825.
Chen E.Y.H., The Psychosis Recovery inventory, Harvard Global Mental Health Seminar. Boston, Harvard Medical School, 2006.
Chen E.Y.H., Vice President elect, International Early Psychosis Association. 2006.
Chen E.Y.H., 面對思覺失調必須及早治療(健康情報), 都巿日報, 香港, 都巿日報, 2005, 32.
Cheung C., Cheung V., Qiu D.Q., Leung L.H.T., Khong P.L., Chen E.Y.H., Chua S.E. and McAlonan G.M., Diffusion tensor imaging study of periventricular and cortico-cortical white matter dysconnectivty in never-medicated schizophrenia, 13th Biennial Winter workshop on Schizophrenia, Schizophrenia Research. Davos, Seitzerland, 2006, 81: 156.
Cheung J.P.Y., Cheung V., Cheung C., Chen E.Y.H., Tsang J.T.K., Wong J.C.H., Yip L., Tai K.S., Suckling J., Bullmore E., McAlonan G.M. and Chua S.E., A comprehensive computational morphometric analysis of the brain in neuroleptic-naïve schizophrenia, Schizophrenia Research. 2006, 81: 165.
Cheung J.P.Y., Cheung V., Cheung C., Chen E.Y.H., Tsang J.T.K., Wong J.C.H., Yip L., Tai K.S., Suckling J., Bullmore E., McAlonan G.M. and Chua S.E., Early striatal & extrastriatal cerebral grey matter excess within 3 weeks of anti-psychotic treatment in schizophrenia, 13th Biennial Winter Workshop on Schizophrenia, Schizophrenia Research. Davos, Switzerland, 2006, 81: 156.
Cheung V., Cheung C., Sham P.C., Leung P.W.L., Khong P.L., Chua S.E., Chen E.Y.H. and McAlonan G.M., Relationship between volumetric structural abnormalities and white matter dysconnectivity in never-medicated patients with first-episode psychosis , 12th. Annual Meeting Human Brain Mapping. Florence, Italy, 2006.
Cheung V., Cheung C., Qiu D.Q., Khong P.L., Chen E.Y.H., McAlonan G.M. and Chua S.E., White matter dyconnectivity of cortico-stratal areas and the relation with executive functioning in never-medicated patients with first-episode psychosis, 12th. Annual Meeting Human Brain Mapping. Florence, Italy, 2006.
Chiang J.C.S., Chow A.S.Y., Chan R.C.K., Law C.W. and Chen E.Y.H., Pathway to Care for Patients with First-episode Psychosis in Hong Kong, Hong Kong Journal of Psychiatry. 2005, 15: 18-22.
Chiu C.P.Y. and Chen E.Y.H., Schizophrenia, In: Chiu EYK, Chiu HFK, Kua EHK, Xin Y, Textbook in Psychiatry for Asia. Beijing, Peking University Medical Press, 2006.
Chiu C.P.Y., Law C.W., Dunn E.L.W. and Chen E.Y.H., The experience of stigmatization in first episode psychosis, Fourth Pan-Asia Pacific Conference on Mental Health (PAPCMH), November 14-17. Shanghai, 2005, 63.
Ho G.S.M. and Chen E.Y.H., Impact of Stigmatization on Outcome of Psychiatric Disorders, Medical Progress. 2005, 525-530.
Honer W.G., Thornton A.E., Chen E.Y.H., Chan R.C.K., Wong J.O.Y., Bergmann A., Falkai P., Pomarol-Clotet E., McKenna P.J., Stip E., Williams R., MacEwan G.W., Wasan K. and Procyshyn K., Clozapine alone versus clozapine and risperidone with refractory schizophrenia, New England Journal of Medicine. 2006, 354: 472-482.
Hui L.M.C., Chen E.Y.H., Kan C.S., Yip K.C., Law C.W. and Chiu C.P.Y., Anti-psychotics adherence among out-patients with schizophrenia in Hong Kong, The Keio Journal of Medicine. Tokyo, school of medicine, Keio University, 2006, 55 no. 1: 9-14.
Hui L.M.C., Chen E.Y.H., Kan C.S., Yip K.C., Law C.W. and Chiu C.P.Y., Detection of non-adherent behavior in early psychosis, Australian and New Zealand Journal of Psychiatry. 2005, 40: 446-451.
Hui L.M.C., Chen E.Y.H., Chiu C.P.Y. and Law C.W., Executive function and relapse in first-episode psychosis, Fourth Pan-Asia Pacific Conference on Mental Health (PAPCMH), November 14-17. Shanghai, 2005, 63.
Hui L.M.C. and Chen E.Y.H., Medication adherence and relapse in first episode psychosis in Hong Kong, Annual Seminar Meeting, Department of Social Medicine, Harvard Medical School. Boston, 2006.
Hui L.M.C. and Chen E.Y.H., Relapse prevention in an Asian context: medication adherence in first-episode psychosis in Hong Kong (Invited Oral Presentation), The 9th Annual Meeting Japanese Society of Prevention in Psychiatric Disorders. Tokyo, Japan, 2006.
Hui L.M.C., Chen E.Y.H., Wong C.K., Chan W.F. and Tang O.W.N., The course of semantic memory dysfunction in first-episode schizophrenia: a prospective 3-year longitudinal study, 13th Biennial Winter Workshop on Schizophrenia Research. Davos, 2006.
Hui L.M.C., Chen E.Y.H., Wong C.K., Dunn E.L.W., Chan W.F., Miao Y.K., Yeung W.S. and Tang O.W.N., The course of semantic memory dysfunction in first-episode schizophrenia, Schizophrenia Research. 2006, 81: 111.
Lam M., Hung S.F. and Chen E.Y.H., Transition to psychosis: 6-month follow up of a Chinese high risk group in Hong Kong , Australian and New Zealand Journal of Psychiatry. 2005, 40: 414-420.
Lam M.L.M., Hung S.F. and Chen E.Y.H., Transition to psychosis: a prospective study of a Chinese high risk group in Hong Kong. , Proceedings of the Fourth Pan-Asia Pacific Conference on Mental Health (PAPCMH), November 14-17. Shanghai, 2005, 62.
Law C.W., Chen E.Y.H., Cheung E.F.C., Chan R.C.K., Wong J.G.W.S., Lam C.L.K., Leung K.F. and Lo M.S.M., Impact of Untreated Psychosis on Quality of Life in Patients with First-episode Schizophrenia, Quality of Life Research. 2005, 14: 1803-1811.
Lee T.M.C., Chan M.W.C., Gao J.L., Chen E.Y.H., Wang K. and Chan C.C.H., The nature of prose memory deficits associated with schizophrenia, Schizophrenia Research. 2006, 81: 199-209.
Lee W.Y., Chen R.Y.L., Chum K.W.C., Chau W.Y., Lee A.M., Chen E.Y.H., Tang S.W. and Sham P.C., Psychiatric comorbidity of substance use disorder and pathological gambling in Hong Kong Chinese, Paper presented at the Australian National Association for Gambling Studies (January 2006). 2006.
Lu Z., Tseng S.M., Hu J., Chen C.K., Diokno Jr G.L., Lee B.Y., Chen E.Y.H., Harrison G.A., McElroy H.J. and Buenaventura R., Effectiveness and safety of olanzapine in the treatment of schizophrenia among Asian patients switching from conventional antipsychotics, Psychotic disorders and antipsychotics. 2005, S471.
Moritz S., Woodward T.S. and Chen E.Y.H., Investigation of metamemory dysfunctions in first-episode schizophrenia, Schizophrenia Research. 2006, 81(2-3): 247-252.
Ran M., Chan C.L.W., Chen E.Y.H., Mao W.J., Hu S.H., Tang C.P., Lin F.R. and Conwell Y., The influence of caregivers on treatment of patients with schizophrenia in rural China, Schizophrenia Research. 2006, 81: 63.
Ran M.S., Chan C.L.W., Chen E.Y.H., Xiang M.Z., Caine E.D. and Conwell Y., Homelessness among patients with schizophrenia in rural China: a 10-year cohort study, Acta Psychiatrica Scandinavica. 2006, 114(2): 118-123.
Ran M.S., Chen E.Y.H., Chan C.L., Yip P.S., Conwell Y. and Caine E., The characteristics of homeless individuals with schizophrenia in rural China, Schizophrenia Bulletin. 2006, 31: 235.
Wong J.C.H., Cheung V., Cheung C., Chen E.Y.H., Tsang J.T.K., Yip L., Tai K.S., Suckling J., Bullmore E., McAlonan G.M. and Chua S.E., Bilateral caudate volume deficits in never-treated schizophrenia, 13th Biennial Winter Workshop On Schizophrenia, Schizophrenia Research. Davos, Switzerland, 2006, 81: 167.
Woodward T.S., Moritz S. and Chen E.Y.H., Letter to the Editor: The Contribution of a Cognitive Bias against Disconfirmatory Evidence (BADE) to Delusions: a Study in an Asian Sample with First Episode Schizophrenia Spectrum Disorders, Schizophrenia Research. 2006, 83/2-3: 297-298.
Woodward T.S., Moritz S. and Chen E.Y.H., The contribution of a cognitive bias against disconfirmatory evidence to delusions in first episode schizophrenia, Schizophrenia Research. 2006, 81: 131.


Researcher : Chen RYL

Project Title:Psychological and biological risk factors associated with Pathological Gambling
Investigator(s):Chen RYL, Sham PC
Department:Psychiatry
Source(s) of Funding:Small Project Funding
Start Date:11/2004
Abstract:
To identify psychological risk factors in terms of personality traits as well as genetic risk factors in terms of genetic polymorphisms with respects to certain candidate genes associated with Pathological Gambling (PG) in Hong Kong Chinese; to figure out the patterns in terms of the risk factors mentioned in pathological gamblers engaging in different forms of gambling.


List of Research Outputs

Chan R.C.K., Chen E.Y.H., Cheung E.F.C., Chen R.Y.L. and Cheung H.K., The components of executive functioning in a cohort of patients with chronic schizophrenia: a multiple single-case study design, Schizophrenia Research. 2006, 81(2-3): 173-189.
Lee W.Y., Chen R.Y.L., Chum K.W.C., Chau W.Y., Lee A.M., Chen E.Y.H., Tang S.W. and Sham P.C., Psychiatric comorbidity of substance use disorder and pathological gambling in Hong Kong Chinese, Paper presented at the Australian National Association for Gambling Studies (January 2006). 2006.
Ng M.L., Chen R.Y.L. and Lee W.Y., Attitude, Behavior and Psychophysiological Responses to Gambling in Chinese Macau Gambling Workers, Inaugural Asian Pacific Problem Gambling Conference (2005-11- 23). 2005, 37-38.


Researcher : Cheung C

List of Research Outputs

Cheung C., Cheung V., Qiu D.Q., Leung L.H.T., Khong P.L., Chen E.Y.H., Chua S.E. and McAlonan G.M., Diffusion tensor imaging study of periventricular and cortico-cortical white matter dysconnectivty in never-medicated schizophrenia, 13th Biennial Winter workshop on Schizophrenia, Schizophrenia Research. Davos, Seitzerland, 2006, 81: 156.
Cheung J.P.Y., Cheung V., Cheung C., Chen E.Y.H., Tsang J.T.K., Wong J.C.H., Yip L., Tai K.S., Suckling J., Bullmore E., McAlonan G.M. and Chua S.E., A comprehensive computational morphometric analysis of the brain in neuroleptic-naïve schizophrenia, Schizophrenia Research. 2006, 81: 165.
Cheung J.P.Y., Cheung V., Cheung C., Chen E.Y.H., Tsang J.T.K., Wong J.C.H., Yip L., Tai K.S., Suckling J., Bullmore E., McAlonan G.M. and Chua S.E., Early striatal & extrastriatal cerebral grey matter excess within 3 weeks of anti-psychotic treatment in schizophrenia, 13th Biennial Winter Workshop on Schizophrenia, Schizophrenia Research. Davos, Switzerland, 2006, 81: 156.
Cheung V., Cheung C., Sham P.C., Leung P.W.L., Khong P.L., Chua S.E., Chen E.Y.H. and McAlonan G.M., Relationship between volumetric structural abnormalities and white matter dysconnectivity in never-medicated patients with first-episode psychosis , 12th. Annual Meeting Human Brain Mapping. Florence, Italy, 2006.
Cheung V., Cheung C., Qiu D.Q., Khong P.L., Chen E.Y.H., McAlonan G.M. and Chua S.E., White matter dyconnectivity of cortico-stratal areas and the relation with executive functioning in never-medicated patients with first-episode psychosis, 12th. Annual Meeting Human Brain Mapping. Florence, Italy, 2006.
Chua S.E., Cheung C., McAlonan G.M., Lam I.W.S., Cheung V., Wong K.W.T., Chan E.K.C., Mak-Lieh F., Tai K.S., Yip L.K.C. and McGuire P.K., Functional Magnetic Resonance Imaging Evaluation of Bilateral Brain Activation in Chinese Speech, Hong Kong Journal of Psychiatry. 2006, 15(2): 77-81.
Wong J.C.H., Cheung V., Cheung C., Chen E.Y.H., Tsang J.T.K., Yip L., Tai K.S., Suckling J., Bullmore E., McAlonan G.M. and Chua S.E., Bilateral caudate volume deficits in never-treated schizophrenia, 13th Biennial Winter Workshop On Schizophrenia, Schizophrenia Research. Davos, Switzerland, 2006, 81: 167.


Researcher : Cheung EFC

List of Research Outputs

Law C.W., Chen E.Y.H., Cheung E.F.C., Chan R.C.K., Wong J.G.W.S., Lam C.L.K., Leung K.F. and Lo M.S.M., Impact of Untreated Psychosis on Quality of Life in Patients with First-episode Schizophrenia, Quality of Life Research. 2005, 14: 1803-1811.


Researcher : Cheung EPT

List of Research Outputs

Wong J.G.W.S., Patil N.G., Beh S.L., Cheung E.P.T., Wong V., Chan L.C. and Mak-Lieh F., Cultivating psychological well-being in Hong Kong's future doctors, Medical Teacher. 2005, 27(8): 715-9.
Wong J.G.W.S., Cheung E.P.T., Chan K.K.C., Ma K.K.M. and Tang S.W., Web-based survey of depression, anxiety and stress in first-year tertiary education students in Hong Kong., Australian and New Zealand Journal of Psychiatry. 2006, 40: 777-782.


Researcher : Cheung V

List of Research Outputs

Cheung C., Cheung V., Qiu D.Q., Leung L.H.T., Khong P.L., Chen E.Y.H., Chua S.E. and McAlonan G.M., Diffusion tensor imaging study of periventricular and cortico-cortical white matter dysconnectivty in never-medicated schizophrenia, 13th Biennial Winter workshop on Schizophrenia, Schizophrenia Research. Davos, Seitzerland, 2006, 81: 156.
Cheung J.P.Y., Cheung V., Cheung C., Chen E.Y.H., Tsang J.T.K., Wong J.C.H., Yip L., Tai K.S., Suckling J., Bullmore E., McAlonan G.M. and Chua S.E., A comprehensive computational morphometric analysis of the brain in neuroleptic-naïve schizophrenia, Schizophrenia Research. 2006, 81: 165.
Cheung J.P.Y., Cheung V., Cheung C., Chen E.Y.H., Tsang J.T.K., Wong J.C.H., Yip L., Tai K.S., Suckling J., Bullmore E., McAlonan G.M. and Chua S.E., Early striatal & extrastriatal cerebral grey matter excess within 3 weeks of anti-psychotic treatment in schizophrenia, 13th Biennial Winter Workshop on Schizophrenia, Schizophrenia Research. Davos, Switzerland, 2006, 81: 156.
Cheung V., Cheung C., Sham P.C., Leung P.W.L., Khong P.L., Chua S.E., Chen E.Y.H. and McAlonan G.M., Relationship between volumetric structural abnormalities and white matter dysconnectivity in never-medicated patients with first-episode psychosis , 12th. Annual Meeting Human Brain Mapping. Florence, Italy, 2006.
Cheung V., Cheung C., Qiu D.Q., Khong P.L., Chen E.Y.H., McAlonan G.M. and Chua S.E., White matter dyconnectivity of cortico-stratal areas and the relation with executive functioning in never-medicated patients with first-episode psychosis, 12th. Annual Meeting Human Brain Mapping. Florence, Italy, 2006.
Chua S.E., Cheung C., McAlonan G.M., Lam I.W.S., Cheung V., Wong K.W.T., Chan E.K.C., Mak-Lieh F., Tai K.S., Yip L.K.C. and McGuire P.K., Functional Magnetic Resonance Imaging Evaluation of Bilateral Brain Activation in Chinese Speech, Hong Kong Journal of Psychiatry. 2006, 15(2): 77-81.
Wong J.C.H., Cheung V., Cheung C., Chen E.Y.H., Tsang J.T.K., Yip L., Tai K.S., Suckling J., Bullmore E., McAlonan G.M. and Chua S.E., Bilateral caudate volume deficits in never-treated schizophrenia, 13th Biennial Winter Workshop On Schizophrenia, Schizophrenia Research. Davos, Switzerland, 2006, 81: 167.


Researcher : Chiu CPY

List of Research Outputs

Chiu C.P.Y. and Chen E.Y.H., Schizophrenia, In: Chiu EYK, Chiu HFK, Kua EHK, Xin Y, Textbook in Psychiatry for Asia. Beijing, Peking University Medical Press, 2006.
Chiu C.P.Y., Law C.W., Dunn E.L.W. and Chen E.Y.H., The experience of stigmatization in first episode psychosis, Fourth Pan-Asia Pacific Conference on Mental Health (PAPCMH), November 14-17. Shanghai, 2005, 63.
Hui L.M.C., Chen E.Y.H., Kan C.S., Yip K.C., Law C.W. and Chiu C.P.Y., Anti-psychotics adherence among out-patients with schizophrenia in Hong Kong, The Keio Journal of Medicine. Tokyo, school of medicine, Keio University, 2006, 55 no. 1: 9-14.
Hui L.M.C., Chen E.Y.H., Kan C.S., Yip K.C., Law C.W. and Chiu C.P.Y., Detection of non-adherent behavior in early psychosis, Australian and New Zealand Journal of Psychiatry. 2005, 40: 446-451.
Hui L.M.C., Chen E.Y.H., Chiu C.P.Y. and Law C.W., Executive function and relapse in first-episode psychosis, Fourth Pan-Asia Pacific Conference on Mental Health (PAPCMH), November 14-17. Shanghai, 2005, 63.


Researcher : Chua SE

Project Title:Brain mapping social impairment in autism
Investigator(s):Chua SE, Fung PCW, Tai KS, McAlonan GM
Department:Psychiatry
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:02/2004
Abstract:
To determine what regions of brain contribute to social impairment in children with autism; the results of the study will help elucidate the causes of autism, and perhaps lead to more effective treatments.


Project Title:Anatomy and connectivity in Attention Deficit-Hyperactivity Disorder (ADHD). A voxel based morphometry and diffusion tensor imaging study.
Investigator(s):Chua SE, McAlonan GM, Khong PL, Tai KS, Cheung V
Department:Psychiatry
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:02/2005
Abstract:
1) To assess the integrity of white matter tracts connecting regions of neuropathology considered important to control of attention and executive processes. With the advent of Diffusion Tensor Imaging (DTI) we are now in a position to do this and in the current project will apply this "cutting-edge" technology to the problem of ADHD 2) This study will rescan the children scanned 4 years ago in our first investigation and examine brain maturational progress in conjunction with symptom rating.


Project Title:An MRI study of childhood attention deficit-hyperactivity disorder (ADHD) using voxel-based morphometry (VBM) and diffusion tensor imaging (DTI)
Investigator(s):Chua SE
Department:Psychiatry
Source(s) of Funding:Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:07/2005
Completion Date:06/2006
Abstract:
N/A


Project Title:Early effects of anti-psychotic drugs on brain growth and gene expression in schizophrenia. A pilot study.
Investigator(s):Chua SE, McAlonan GM, Chen EYH, Wong JGWS, Law CW, Chiu CPY
Department:Psychiatry
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:02/2006
Abstract:
OBJECTIVES : This is a pilot study to investigate the feasibility of using MRI and microarray to study the early effects of anti-psychotic drugs on brain growth and gene expression. Since microarray is expensive, with budget constraints it is fair to adopt a sample size of n=6. Our project objectives are to determine the feasibility of : (1) recruitment of subjects with first-onset schizophrenia (n=12) for MRI brain scan at time 0 and 3 weeks, (2) peripheral blood taking of these subjects at weeks 0, 3 (3) microarray analysis protocol (n=6, see below) at the Genome Research Centre . SUMMARY : Schizophrenia is a heritable, serious mental disorder, affecting 1% people worldwide. It usually presents in young adults with psychosis i.e. hallucinations or delusions. Anti-psychotic drugs classically block dopamine receptors in the basal ganglia (striatum) in the brain and take effect after 3 weeks (Johnstone et al 1978). There are a range of brain morphological abnormalities in schizophrenia including ventricular enlargement, smaller brain volume, reduced fronto-temporal volume, increased caudate volume (Wright et al 2000) but these have mainly been studied in chornic patients who have been treated with neuroleptic medication. Chronicity and neuroleptic treatment are known to affect interpretation of brain morphological differences. Thus, in recent years, the research focus in brain imaging has turned to newly-ill and neuroleptic-naïve patients. In the first comprehensive voxel-based MRI study of never-medicated patients with first episode of schizophrenia, we reported significantly smaller volumes of caudate nuclei of the dopamine-rich basal ganglia (Chua et al, 2005a, in submission). Current evidence suggests anti-psychotics reverse this abnormality after 3 (Massana et al 2005) to 15 months (Chakos 1994). However, our pilot data comparing medicated and never-medicated patients with schizophrenia clearly suggested caudate volume normalization as early as 3 weeks post-treatment (Chua et al, 2005b, in submission). Coinciding with clinical recovery, it suggests a role for anti-psychotic agents in gene expression controlling brain growth. We now ask : (1) Can this novel effect be confirmed in a single cohort of individuals pre and post treatment and what is its genetic basis? We propose a prospective longitudinal MRI and gene expression study of a single patient cohort with first-episode schizophrenia (n=20). Each will have MRI brain scan before and 3 weeks after treatment to assess brain morphology, with blood samples drawn at weekly intervals for microarray analysis of genetic markers for brain growth. No previous study has examined such early treatment-induced brain changes. This will help to provide a benchmark for assessing effectiveness of drugs in the early treatment of schizophrenia and open new avenues for drug development. PURPOSE : We propose to use MRI brain in a single group of patients with schizophrenia to demonstrate that a robust neurotrophic effect occurs within 3 weeks of treatment as symptoms improve. In addition, we shall perform a microarray analysis to study candidate gene markers which govern brain neurotrophic changes and clinical response. KEY ISSUES & PROBLEMS ADDRESSED : 1. Anti-psychotic drugs markedly reduce symptoms within the first 3 weeks of treatment (Johnstone et al 1978) and 68% of the improvement at 1 year is achieved within the 1st month (Leucht et al 2005). However, the underlying mechanism for this time lag to clinical effect is not understood. 2. In a recent study, our group found that patients with schizophrenia (n=29) who had never previoulsy been exposed to any medication, have smaller regional brain volumes compared to typically developing individuals (n=40) (Chua et al, a, in submission). In another related study, we found that a similar group of schizophrenic patients (n=12) who had received antipsychotic medication for 3 weeks showed early "normalisation" of these above brain volume deficits ie the deficits appeared to reverse especially in the (dopamine-rich) basal ganglia (striatum) of the brain. Therefore the issue is whether this represents an early neurotrophic effect which corresponds to clinical response. 3. Therefore this pilot study addresses the feasibility of recruiting a single cohort (n=12) of patients who will (i) undergo MRI brain scan at weeks 0 and 3 and (ii) have perpheral whole blood-taking at weekly intervals for gene expression pattern changes during early 3 weeks of treatment. The purpose of this is (iii) to identify genes which may be involved in early symptom response and be involved in control of early brain volume changes. In other words, this project addresses the core question of whether treatment effectiveness might depend on neural circuity "re-wiring" (Konradi & Heckers 2001).


List of Research Outputs

Cheung C., Cheung V., Qiu D.Q., Leung L.H.T., Khong P.L., Chen E.Y.H., Chua S.E. and McAlonan G.M., Diffusion tensor imaging study of periventricular and cortico-cortical white matter dysconnectivty in never-medicated schizophrenia, 13th Biennial Winter workshop on Schizophrenia, Schizophrenia Research. Davos, Seitzerland, 2006, 81: 156.
Cheung J.P.Y., Cheung V., Cheung C., Chen E.Y.H., Tsang J.T.K., Wong J.C.H., Yip L., Tai K.S., Suckling J., Bullmore E., McAlonan G.M. and Chua S.E., A comprehensive computational morphometric analysis of the brain in neuroleptic-naïve schizophrenia, Schizophrenia Research. 2006, 81: 165.
Cheung J.P.Y., Cheung V., Cheung C., Chen E.Y.H., Tsang J.T.K., Wong J.C.H., Yip L., Tai K.S., Suckling J., Bullmore E., McAlonan G.M. and Chua S.E., Early striatal & extrastriatal cerebral grey matter excess within 3 weeks of anti-psychotic treatment in schizophrenia, 13th Biennial Winter Workshop on Schizophrenia, Schizophrenia Research. Davos, Switzerland, 2006, 81: 156.
Cheung V., Cheung C., Sham P.C., Leung P.W.L., Khong P.L., Chua S.E., Chen E.Y.H. and McAlonan G.M., Relationship between volumetric structural abnormalities and white matter dysconnectivity in never-medicated patients with first-episode psychosis , 12th. Annual Meeting Human Brain Mapping. Florence, Italy, 2006.
Cheung V., Cheung C., Qiu D.Q., Khong P.L., Chen E.Y.H., McAlonan G.M. and Chua S.E., White matter dyconnectivity of cortico-stratal areas and the relation with executive functioning in never-medicated patients with first-episode psychosis, 12th. Annual Meeting Human Brain Mapping. Florence, Italy, 2006.
Chua S.E., Cheung C., McAlonan G.M., Lam I.W.S., Cheung V., Wong K.W.T., Chan E.K.C., Mak-Lieh F., Tai K.S., Yip L.K.C. and McGuire P.K., Functional Magnetic Resonance Imaging Evaluation of Bilateral Brain Activation in Chinese Speech, Hong Kong Journal of Psychiatry. 2006, 15(2): 77-81.
Chua S.E. and McAlonan G.M., 腦部社交區變異與自閉症的關係 (健康情報), Metropoplis Daily. 都巿日報, 香港, 都巿日報, 2005, 32.
Chua S.E., TVB Interview Interactive Health Programme about Autism on 17 March 2006. 2006.
Khong P.L., Qiu D., Yung A.W.Y., Poon G.W.K., Leung C., Chua S.E., McAlonan G.M. and Lam B.C.C., White matter volume and anisotropy in very low birth weight preterm born children: association with cognitive outcome, 14th Scientific Meeting & Exhibition, Seattle, Washington, USA, 6-12 May 2006.
McAlonan G.M. and Chua S.E., HKU Autism Research Finds Changes in Brain Regions which Control Social Ability, Apple Daily. 2005, A24.
McAlonan G.M. and Chua S.E., HKU Autism Research Finds Changes in Brain Regions which Control Social Ability, Hong Kong Daily News. 2005, A8.
McAlonan G.M. and Chua S.E., HKU Autism Research Finds Changes in Brain Regions which Control Social Ability, Hong Kong Economic Times. 2005, A29.
McAlonan G.M. and Chua S.E., HKU Autism Research Finds Changes in Brain Regions which Control Social Ability, Ming Pao. 2005, A16.
McAlonan G.M. and Chua S.E., HKU Autism Research Finds Changes in Brain Regions which Control Social Ability, Oriental Daily. 2005, A39.
McAlonan G.M. and Chua S.E., HKU Autism Research Finds Changes in Brain Regions which Control Social Ability, Sing Tao. 2005, A9.
McAlonan G.M. and Chua S.E., HKU Autism Research Finds Changes in Brain Regions which Control Social Ability, The Sun. 2005, A31.
McAlonan G.M. and Chua S.E., HKU Autism Research Finds Changes in Brain Regions which Control Social Ability, Wen Wei Po. 2005, A14.
McAlonan G.M. and Chua S.E., Learning to understand autism, HKU Bulletin. 2006, Apr vol 7: no. 5, 11.
Wong J.C.H., Cheung V., Cheung C., Chen E.Y.H., Tsang J.T.K., Yip L., Tai K.S., Suckling J., Bullmore E., McAlonan G.M. and Chua S.E., Bilateral caudate volume deficits in never-treated schizophrenia, 13th Biennial Winter Workshop On Schizophrenia, Schizophrenia Research. Davos, Switzerland, 2006, 81: 167.


Researcher : Chum KWC

List of Research Outputs

Lee W.Y., Chen R.Y.L., Chum K.W.C., Chau W.Y., Lee A.M., Chen E.Y.H., Tang S.W. and Sham P.C., Psychiatric comorbidity of substance use disorder and pathological gambling in Hong Kong Chinese, Paper presented at the Australian National Association for Gambling Studies (January 2006). 2006.


Researcher : Chung KF

Project Title:Seizure threshold of unilateral electroconvulsive therapy
Investigator(s):Chung KF, Wong SJ
Department:Psychiatry
Source(s) of Funding:Other Funding Scheme
Start Date:07/2001
Abstract:
To find out the seizure threshold of electroconvulsive therapy and its predictors in Chinese.


Project Title:Influence of a psychiatric clerkship on medical students' attitudes toward psychiatry and mental patients
Investigator(s):Chung KF
Department:Psychiatry
Source(s) of Funding:Other Funding Scheme
Start Date:01/2002
Abstract:
To compare the effect of a standard clerkship with one augmented with a 1-hour stigma-changing programme on students' attitudes toward mental illness.


Project Title:Response to moderately suprathreshold unilateral (UL) electroconvulsive therapy (ECT): an examination of possible predictors
Investigator(s):Chung KF, Irwin MG
Department:Psychiatry
Source(s) of Funding:Other Funding Scheme
Start Date:06/2002
Abstract:
To examine factors that associate with response to moderately suprathereshold unilateral ECT.


List of Research Outputs

Chung K.F., Changing the Attitudes of Hong Kong Medical Students Toward People with Mental Illness, Journal of Nervous and Mental Disease. Lippincott Williams & Wilkins, 2005, 193, no. 11: 766-768.
Chung K.F., Determinants of seizure threshold of electroconvulsive therapy in Chinese, Journal of ECT. 2006, 22(2): 100-102.
Chung K.F., Insomnia Subtypes and Their Relationship to Daytime Sleepiness in Patients with Obstructive Sleep Apnea, Respiration. Basel, S. Karger Medical and Scientific Publishers, 2005, 72: 460-465.
Chung K.F. and Cheung M.M., Sleep pattern and problems in Hnog Kong adolescents, Annual Scientific meeting of the Hong Kong College of Sleep Medicine. 2005.
Chung K.F. and Tang M.K., Subjective sleep disturbance and its correlates in middle-aged Hong Kong Chinese women, Maturitas. Elsevier, 2005, 53: 396-404.
Lee A.M., Wei R., Chung K.F., Hui K.T., Ip S.K., Leung H.L., Liu H.L., Lui S.Y., Ng Y.H., Wong M.F. and Wong T.C., Premenstrual Syndrome among Chinese female undergradutes: Relationship with stress and general mental health, Hong Kong Journal of Gynaecology, Obstetrics and Midwifery. 2005, 5: 10-21.


Researcher : Dunn ELW

List of Research Outputs

Chen E.Y.H., Hui L.M.C., Wong C.K., Dunn E.L.W., Chan W.F., Miao Y.K., Yeung W.S. and Tang O.W.N., Long duration of untreated psychosis is associated with poorer neurocognitive and negative symptom recovery after first episode schizophrenia, Schizophrenia Research. 2006, 81: 231.
Chiu C.P.Y., Law C.W., Dunn E.L.W. and Chen E.Y.H., The experience of stigmatization in first episode psychosis, Fourth Pan-Asia Pacific Conference on Mental Health (PAPCMH), November 14-17. Shanghai, 2005, 63.
Hui L.M.C., Chen E.Y.H., Wong C.K., Dunn E.L.W., Chan W.F., Miao Y.K., Yeung W.S. and Tang O.W.N., The course of semantic memory dysfunction in first-episode schizophrenia, Schizophrenia Research. 2006, 81: 111.


Researcher : Fung ASM

List of Research Outputs

Chan Y.M., Lee P.W.H., Fong D.Y.T., Fung A.S.M., Wu L.Y.F., Choi A.Y., Ng T.Y., Ngan H.Y.S. and Wong L.C., Effect of individual psychological intervention in Chinese women with gynecologic malignancy: A randomized controlled trial, Journal of Clinical Oncology. 2005, 23(22): 4913-4924.


Researcher : Fung PCW

Project Title:Development of a novel natural antioxidant with strong anti-aging and protective properties for skin
Investigator(s):Fung PCW, Shen J
Department:Medicine
Source(s) of Funding:Seed Funding Programme for Applied Research
Start Date:07/2002
Abstract:
To develop a novel antioxidants from herbal products which can scavenge superoxide, hydroxyl and lipid peroxide free radicals in skin.


Project Title:Roles of plasma membrane cholesterol homeostasis in regulating neuronal oxidative damage of ischemic stroke
Investigator(s):Fung PCW, Shen J
Department:Medicine
Source(s) of Funding:Small Project Funding
Start Date:11/2003
Abstract:
To understand the roles of plasma membrane cholesterol homeostasis in protecting neuronal cells from oxidative damage during ischemic stroke.


Project Title:High level brain activity studies and applications
Investigator(s):Fung PCW, Chang C, Gao S.K., Gao X.R., Zhang Z.G., Yang F.S., Poon P.W.F., Chan FHY
Department:Medicine
Source(s) of Funding:NSFC/RGC Joint Research Scheme
Start Date:01/2004
Abstract:
To better understand and utilize the functioning of the brain.


List of Research Outputs



Researcher : Ho GSM

List of Research Outputs

Ho G.S.M. and Chen E.Y.H., Impact of Stigmatization on Outcome of Psychiatric Disorders, Medical Progress. 2005, 525-530.


Researcher : Hui LMC

List of Research Outputs

Chen E.Y.H., Hui L.M.C., Wong C.K., Dunn E.L.W., Chan W.F., Miao Y.K., Yeung W.S. and Tang O.W.N., Long duration of untreated psychosis is associated with poorer neurocognitive and negative symptom recovery after first episode schizophrenia, Schizophrenia Research. 2006, 81: 231.
Hui L.M.C., Chen E.Y.H., Kan C.S., Yip K.C., Law C.W. and Chiu C.P.Y., Anti-psychotics adherence among out-patients with schizophrenia in Hong Kong, The Keio Journal of Medicine. Tokyo, school of medicine, Keio University, 2006, 55 no. 1: 9-14.
Hui L.M.C., Chen E.Y.H., Kan C.S., Yip K.C., Law C.W. and Chiu C.P.Y., Detection of non-adherent behavior in early psychosis, Australian and New Zealand Journal of Psychiatry. 2005, 40: 446-451.
Hui L.M.C., Chen E.Y.H., Chiu C.P.Y. and Law C.W., Executive function and relapse in first-episode psychosis, Fourth Pan-Asia Pacific Conference on Mental Health (PAPCMH), November 14-17. Shanghai, 2005, 63.
Hui L.M.C. and Chen E.Y.H., Medication adherence and relapse in first episode psychosis in Hong Kong, Annual Seminar Meeting, Department of Social Medicine, Harvard Medical School. Boston, 2006.
Hui L.M.C. and Chen E.Y.H., Relapse prevention in an Asian context: medication adherence in first-episode psychosis in Hong Kong (Invited Oral Presentation), The 9th Annual Meeting Japanese Society of Prevention in Psychiatric Disorders. Tokyo, Japan, 2006.
Hui L.M.C., Chen E.Y.H., Wong C.K., Chan W.F. and Tang O.W.N., The course of semantic memory dysfunction in first-episode schizophrenia: a prospective 3-year longitudinal study, 13th Biennial Winter Workshop on Schizophrenia Research. Davos, 2006.
Hui L.M.C., Chen E.Y.H., Wong C.K., Dunn E.L.W., Chan W.F., Miao Y.K., Yeung W.S. and Tang O.W.N., The course of semantic memory dysfunction in first-episode schizophrenia, Schizophrenia Research. 2006, 81: 111.


Researcher : Khong PL

Project Title:To establish the use of magnetic resonance imaging for assessing the degree of brain damage following hypoxic ischemic insult with or without neuroprotective therapies
Investigator(s):Khong PL, Cheung PT
Department:Diagnostic Radiology
Source(s) of Funding:Other Funding Scheme
Start Date:06/2002
Abstract:
To evaluate the neuroprotective effects of one purified component of Traditional Chinese Medicine (TCM), caspase inhibitor (CI) and cyclosporin A (CA), in combination or alone.


Project Title:Diffusion tensor MR imaging (DTI) for the detection and quantification of treatment-induced white matter injury in childhood tumours
Investigator(s):Khong PL, Ooi CGC, Kwong DLW, Chan GCF
Department:Diagnostic Radiology
Source(s) of Funding:Competitive Earmarked Research Grants (CERG)
Start Date:11/2003
Completion Date:10/2005
Abstract:
To test the following hypotheses in acute lymphoblastic leukemia and childhood brain tumour survivors who have undergone cranial irradiation +/- chemotherapy: 1) Loss of anisotropy (i.e. reduction in FA) occurs in the white matter cranial irradiation and chemotherapy, and this is dose dependent; DTI is more sensitive for detection of treatment-induced white-matter injury compared to conventional MRI; White matter FA correlates with cognitive function; to determine if DTI is sensitive and accurate for detecting, quantifying and monitoring treatment-induced neurotoxicity.


Project Title:Magnetic resonance imaging of neonatal rat brain to evaluate therapeutic interventions following hypoxic ischemic insult using a 1.5T clinical scanner and a custom made microimaging coil
Investigator(s):Khong PL, Cheung PT, Ooi CGC, Shen GG
Department:Diagnostic Radiology
Source(s) of Funding:Small Project Funding
Start Date:11/2003
Completion Date:04/2006
Abstract:
To evaluate the HIE induced changes by T1-weighted, T2-weighted and diffusion-weighted imaging, and to evaluate therapeutic interventions for neonatal hypoxic-ischaemic brain injuries, using the custom made animal micro-imaging coil (bird-cage coil).


Project Title:Diffusion tensor MR imaging (DTI) for the detection and quantification of treatment-induced white matter injury in childhood tumours
Investigator(s):Khong PL, Ooi CGC, Kwong DLW, Chan GCF
Department:Diagnostic Radiology
Source(s) of Funding:Merit Award for RGC CERG Funded Projects
Start Date:11/2003
Completion Date:10/2005
Abstract:
N/A


Project Title:Diffusion tensor MRI assessment of the brain in low birth weight preterm children
Investigator(s):Khong PL, Ooi CGC
Department:Diagnostic Radiology
Source(s) of Funding:Small Project Funding
Start Date:11/2004
Completion Date:01/2006
Abstract:
To study the FA of the white matter in the brain by DTI, comparing with normal age-matched controls.


Project Title:Whole body magnetic resonance (MR) screening in primary plasmacytomas
Investigator(s):Khong PL, Chim JCS
Department:Diagnostic Radiology
Source(s) of Funding:Small Project Funding
Start Date:11/2004
Abstract:
To evaluate the clinical utility of whole body MR screening to detect occult lesions in the diagnostic work-up of cases with primary plasmacytomas, including primary solitary bone and extramedullary plasmacytomas.


Project Title:Mapping dose distribution on the Fractional Anisotropy Map: Applications in the assessment of treatment-induced white matter injury
Investigator(s):Khong PL, Kwong DLW, Chan GCF
Department:Diagnostic Radiology
Source(s) of Funding:Small Project Funding
Start Date:10/2005
Abstract:
Treatment-induced neurotoxicity is prevalant and impacts significantly on the lives of childhood brain tumour survivors (Mulhern et al., 2004). Whole brain radiotherapy is considered to be the major contributory factor that causes these deficits (Johnson et al., 1994; Mulhern et al., 1998; Silber et al., 1992). It has been shown that white matter is predisposed to radiation-induced injury and that it may be the substrate of neurocognitive deterioration. There is emerging evidence that diffusion tensor MR imaging (DTI), using fractional anisotropy (FA), is sensitive in detecting and monitoring white matter injury in these patients. (Khong et al., 2005b; Khong et al., 2003; Khong et al., 2005a; Leung et al., 2004b). We aim to explore and describe an optimal method to map whole brain radiation dose distribution to the FA images of childhood brain tumour survivors.


List of Research Outputs

Cheung C., Cheung V., Qiu D.Q., Leung L.H.T., Khong P.L., Chen E.Y.H., Chua S.E. and McAlonan G.M., Diffusion tensor imaging study of periventricular and cortico-cortical white matter dysconnectivty in never-medicated schizophrenia, 13th Biennial Winter workshop on Schizophrenia, Schizophrenia Research. Davos, Seitzerland, 2006, 81: 156.
Cheung V., Cheung C., Sham P.C., Leung P.W.L., Khong P.L., Chua S.E., Chen E.Y.H. and McAlonan G.M., Relationship between volumetric structural abnormalities and white matter dysconnectivity in never-medicated patients with first-episode psychosis , 12th. Annual Meeting Human Brain Mapping. Florence, Italy, 2006.
Cheung V., Cheung C., Qiu D.Q., Khong P.L., Chen E.Y.H., McAlonan G.M. and Chua S.E., White matter dyconnectivity of cortico-stratal areas and the relation with executive functioning in never-medicated patients with first-episode psychosis, 12th. Annual Meeting Human Brain Mapping. Florence, Italy, 2006.


Researcher : Ko SN

List of Research Outputs

Ng M.L. and Ko S.N., The state and development of sexual disorder services in Hong Kong, Proceedings of First China International Forum on Sexual Medicine (Oct 21-23). Chongqing China, China Sexology Association, 2005, 22-25.


Researcher : Kuriansky J

List of Research Outputs

Ng M.L., Kuriansky J., Ng T.M.Y. and Cheung B.S.N., The evaluation of a web-based course for professional sex education in Hong Kong, The 28th Congress of the World Federation for Mental Health, Equity and Mental Health. Cairo, 2005.


Researcher : Kwan TTC

List of Research Outputs

Lee P.W.H. and Kwan T.T.C., Death, dying and bereavement: a Hong Kong Chinese experience, In: C.L.W. Chan and A.Y.M. Chow (Eds.) , Providing end-of-life care: enhancing effectiveness and resilience . HKU Press, 2006, 209-224.


Researcher : Lam MLM

List of Research Outputs

Lam M.L.M., Hung S.F. and Chen E.Y.H., Transition to psychosis: a prospective study of a Chinese high risk group in Hong Kong. , Proceedings of the Fourth Pan-Asia Pacific Conference on Mental Health (PAPCMH), November 14-17. Shanghai, 2005, 62.


Researcher : Lau WM

List of Research Outputs

Lau W.M., Qiu G., Helmeste D.M., Lee T.M.C., Tang S.W. and So K.F., Corticosteroid decreases subventricular zone cell proliferation, which could be reserved by paroxetine, Restorative Neurology and Neuroscience (In press). 2006.


Researcher : Law CW

List of Research Outputs

Chan R.C.K., Chen E.Y.H. and Law C.W., Fractionating the executive function in schizophrenia: does it still hold true for medication-naïve sample? , Schizophrenia Research. 2006, 81: 230.
Chiang J.C.S., Chow A.S.Y., Chan R.C.K., Law C.W. and Chen E.Y.H., Pathway to Care for Patients with First-episode Psychosis in Hong Kong, Hong Kong Journal of Psychiatry. 2005, 15: 18-22.
Chiu C.P.Y., Law C.W., Dunn E.L.W. and Chen E.Y.H., The experience of stigmatization in first episode psychosis, Fourth Pan-Asia Pacific Conference on Mental Health (PAPCMH), November 14-17. Shanghai, 2005, 63.
Hui L.M.C., Chen E.Y.H., Kan C.S., Yip K.C., Law C.W. and Chiu C.P.Y., Anti-psychotics adherence among out-patients with schizophrenia in Hong Kong, The Keio Journal of Medicine. Tokyo, school of medicine, Keio University, 2006, 55 no. 1: 9-14.
Hui L.M.C., Chen E.Y.H., Kan C.S., Yip K.C., Law C.W. and Chiu C.P.Y., Detection of non-adherent behavior in early psychosis, Australian and New Zealand Journal of Psychiatry. 2005, 40: 446-451.
Hui L.M.C., Chen E.Y.H., Chiu C.P.Y. and Law C.W., Executive function and relapse in first-episode psychosis, Fourth Pan-Asia Pacific Conference on Mental Health (PAPCMH), November 14-17. Shanghai, 2005, 63.
Law C.W., Chen E.Y.H., Cheung E.F.C., Chan R.C.K., Wong J.G.W.S., Lam C.L.K., Leung K.F. and Lo M.S.M., Impact of Untreated Psychosis on Quality of Life in Patients with First-episode Schizophrenia, Quality of Life Research. 2005, 14: 1803-1811.


Researcher : Lee AM

Project Title:A prospective longitudinal study of disordered eating attitudes and behaviours among pregnant women in Hong Kong
Investigator(s):Lee AM, Lam SK, Lee PWH, Tang LCH
Department:Psychiatry
Source(s) of Funding:Seed Funding for New Staff
Start Date:01/2003
Completion Date:12/2005
Abstract:
To document the level of disordered eating attitudes and behaviours among pregnant women in Hong Kong; to understand the course of disordered eating attitudes and behaviours, and body image disturbance across different stages of pregnancy; to examine the psychological correlates and predictors of disordered eating attitudes and behaviours among pregnant women; to identify pregnant women at high risk of developing disordered eating attitudes and behaviours to guide the development of prevention and early intervention efforts; to examine the relationship between disordered eating during pregnancy and postnatal distress.


Project Title:Psychosocial Group Therapy for Menopausal Women: A model for the non-pharmacological management of menopausal distress
Investigator(s):Lee AM, Leung K. Y.
Department:Psychiatry
Source(s) of Funding:Centre on Behavioral Health Seed Funding Scheme - General Award
Start Date:07/2003
Abstract:
The study aims at developing and evaluating the efficacy of a psychosocial group therapy approach to the management of menopausal problems among Hong Kong women.


Project Title:Neurobiological dysfunction in patients with Severe Acute Respiratory Syndrome (SARS) following corticosteroid treatment: a follow-up study at baseline
Investigator(s):Lee AM, Tang SW, Lee TMC, Chua SE, Tai KS, Yam L.Y.C., Chen RYL
Department:Psychiatry
Source(s) of Funding:VCO SARS Research Fund
Start Date:07/2003
Completion Date:12/2005
Abstract:
To determine the psychiatric comorbidity and neurocognitive impairment of the SARS survivors for 2 years as compared to controls; to determine the level of brain derived neurotropic factor (BDNF) and volumetric change of selected brain regions as biological markers for underlying brain dysfunction; to determine risk factors for the development of psychiatric comorbidity and neurocognitive impairment.


Project Title:Molecular genetic study on the serotonin related behavioural traits in Chinese
Investigator(s):Lee AM, Sham P.C., Chen RYL
Department:Psychiatry
Source(s) of Funding:Small Project Funding
Start Date:11/2003
Completion Date:10/2005
Abstract:
To determine the genetic basis of serotonin dysfunction in association with psycho-behavioural traits associated with the impulsive-compulsive-addictive spectrum in Chinese; to study the differences in behavioural measures between diagnostic groups.


Project Title:The efficacy of group psychosocial intervention on psychological distress, quality of life, and post-traumatic growth among patients with gynaecological cancers: a randomized controlled trial
Investigator(s):Lee AM, Ngan HYS, Chan YM, Tam KF, Lee PWH
Department:Psychiatry
Source(s) of Funding:Small Project Funding
Start Date:11/2003
Abstract:
To systematically test the efficacy of group psychosocial intervention in reducing psychological distress, and improving quality of life and adjustment among patients with gynaecological cancers; to examine the usefulness of group psychosocial intervention in bringing about post-traumatic growth among patients with gynaecological cancers; to examine the course of changes in psychological distress, quality of life, and post-traumatic growth over time; to examine the ability of psychological distress in predicting quality of life, adjustment, and post-traumatic growth at post-intervention and three-month follow-up; to identify therapeutic elements of the group psychosocial intervention programme.


Project Title:A prospective longitudinal study of high-risk behaviors among adolescents in Hong Kong: the effects of modernization and culture
Investigator(s):Lee AM, Stewart SM, Lam TH, Lee PWH, Chan E.S.M.
Department:Psychiatry
Source(s) of Funding:Competitive Earmarked Research Grants (CERG)
Start Date:11/2003
Abstract:
Obtain baseline information on the rates, forms, and patterns of high-risk behaviors among adolescents in Hong Kong; to empirically test the hypothesis that high-risk behaviors (such as smoking, substance abuse, and early sex) represent a single core construct versus the competing hypothesis that they represent multiple constructs or even distinct and isolated behavioral entities; to identify a set of risk and protective factors that may predispose (or protect) adolescents to (from) high-risk behaviors. These risk factors include individual factors as well as measurable vulnerabilities associated with modernization; to understand the developmental trajectories and causative influences of risk factors identified; to examine the longer term consequences (adverse end-points) of high-risk behaviors in terms of a broad range of mental and physical health problems problems as well as functioning.


Project Title:A prospective longitudinal study of high-risk behaviors among adolescents in Hong Kong: the effects of modernization and culture
Investigator(s):Lee AM, Stewart SM, Lam TH, Lee PWH, Chan E.S.M.
Department:Psychiatry
Source(s) of Funding:Merit Award for RGC CERG Funded Projects
Start Date:11/2003
Abstract:
N/A


Project Title:An exploratory study of the male climacteric and its relationship with psychological factors
Investigator(s):Lee AM, Leung SSK, Chen RYL
Department:Psychiatry
Source(s) of Funding:Small Project Funding
Start Date:11/2004
Abstract:
The document the level of ADAM among middle- and old-aged males between the ages of 40 and 80 in Hong Kong; to examine the multidimensional nature of male climacteric problems and its relation to androgen deficiency; to identify the psychological risk factors of male climacteric problems and ADAM; to compare the relative contribution of psychological factors and androgen deficiency to male climacteric problems; to examine the impact of climacteric problems and ADAM on quality of life among males.


Project Title:A randomized contolled trial of the efficacy of a model of psychosocial intervention in improving quality of life and psychological well-being of Chinese patients with colorectal cancer
Investigator(s):Lee AM, Ho W. C., Chan CLW
Department:Psychiatry
Source(s) of Funding:Health and Health Services Research Fund - Full Grants
Start Date:02/2005
Abstract:
The study uses a prospective randomized controlled trial design to systematically assess the efficacy of an Eastern Body-Mind-Spirit (BMS) approach in improving the quality of life and psychological well-being among a sample of colorectal cancer patients in Hong Kong. Its specific objectives are as follows: (i) To examine the efficacy of BMS intervention in improving quality of life and psychological well-being outcomes among CRC patients against a control group that receives no active psychosocial intervention; (ii) To monitor the effectiveness of BMS intervention over time;


Project Title:Translation of the Depression Anxiety and Stress Scales 21- item version (DASS-21) into Chinese and Validation of the Chinese DASS-21 among Clinical and Non-Clinical Samples in Hong Kong
Investigator(s):Lee AM, Wong JGWS, Lam TP, Tang SW
Department:Psychiatry
Source(s) of Funding:Small Project Funding
Start Date:01/2006
Abstract:
PURPOSE OF PROPOSED STUDY: The Depression Anxiety Stress Scales (DASS) (1) has been widely evaluated and shown to be a high quality self-report measure of depression, anxiety, and stress. Its unique capacity to define and distinguish between these three negative emotional states renders it a valuable tool in both research and clinical practice. It is superior to traditional measures of depression, most of which are less pure measures of depression by containing a mixture of depressive and anxiety symptoms; the same being true for traditional measures of anxiety (2,3,4). The DASS-21 is a 21-item short version of the DASS with equally satisfactory psychometric properties (1). It has been translated into a number of different languages, and used among diverse populations (5,6). In Hong Kong, where over 95% of the population are ethnic Chinese, and Chinese is the dominant language of communication, a conceptually equivalent and validated Chinese version the DASS-21 is much needed. The proposed study aims to translate the 21-item version of the Depression Anxiety and Stress Scales (DASS-21) into Chinese and validate it among clinical and non-clinical samples of Hong Kong Chinese. Sepcifically, the proposed study purports to use an established and systematic approach to translate the DASS-21 into Chinese, the product of which will be compared to the original English version by testing on bilingual subjects. Its psychometric properties will then be further examined in both clinical and non-clinical samples with regard to reliability (internal consistency and test-retest reliability), factorial validity, concurrent validity, and convergent and discriminant validity. LITERATURE REVIEW AND KEY ISSUES: The Depression Anxiety Stress Scales (DASS) (1) is a 42-item questionnaire developed to measure the three negative emotional states of depression, anxiety, and stress. It is widely used among Caucasian populations for both clinical and research purposes. The DASS-21 is a short version of the DASS, with three subscales each consisting of 7 items to measure the three negative emotional states. The psychometric properties of both the 42-item original version and the 21-item short version have been examined in non-clinical and clinical samples. Reliability in terms of internal consistency and temporal stability is high across the board. Moreover, convergent and discriminant validity as examined by correlation with other self-report measures of depression and anxiety are consistently satisfactory (2,3,7). The DASS and DASS-21 differ from traditional measures in their proven capacity to distinguish well between anxiety and depressive symptoms, and providing a measure of stress at the same time (2,3,4). Developing suitable instruments for assessing depression and anxiety poses great challenge. This is because although depression and anxiety disorders are conceptualized as distinct clinical entities, there is substantial overlap between the two conditions, and they often co-occur clinically (8). Among non-clinical populations, levels of depression and anxiety also correlate significantly and strongly with each other (9). Existing measures of depression and anxiety fare poorly in distinguishing between these two negative emotional states (3). Clark and Watson (10) developed the tripartite model of anxiety and depression in an attempt to explain the overlap between depression and anxiety. They argued that depression and anxiety have both unique and shared characteristics, with the shared component being elevated negative affect such as irritability and general distress. Based on this model, there are three interrelated negative emotional states, namely, anhedonia, physiological arousal, and general distress. Anhedonia or the absence of positive affect is unique to depression, physiological arousal is unique to anxiety, and general distress is common to both depression and anxiety. Within this theoretical framework, only anhedonia and physiological arousal are specific negative emotional states; general distress represents a non-specific component shared by both depression and anxiety . Lovibond and Lovibond (1,7,11) further identified a third specific and distinct negative emotional state, stress, that is distinct from depression and anxiety on the one hand, and differs from the non-specific symptoms shared by both depression and anxiety (general distress) on the other. This negative emotional state relates to general hyperarousal and is characterized by tension, inability to relax, and overreaction to stressful events. The DASS was conceptually and psychometrically consistent with the tripartite model of anxiety and depression but extends beyond it to include a measure of stress. The Depression scale (DASS-D) measures symptoms unique to depression, and includes items that are associated with dysphoria or an absence of positive affect. The Anxiety scale (DASS-A) measures symptoms unique to anxiety, and includes items that assess symptoms of physiological hyperarousal. Studies clarifying the nature of these symptoms found that symptoms on this scale are particularly characteristic of those experienced by patients with panic disorder (2). The Stress scale (DASS-S) includes items measuring symptoms such as tension, irritability, and tendency to overreact to stressful events. The symptoms on the Stress scale, being characteristic symptoms associated with chronic worry, have been found to be most associated with symptoms of Generalized Anxiety Disorder (GAD), a particular form of anxiety disorder (2). The 21-item version has the obvious advantage of being shorter and quicker to administer, hence more suitable as a screening instrument for assessing primary care patients and community population. Clara et al (12) have used a predominantly depressed sample and shown, through confirmatory factor analysis, support for a 3-factor model for the DASS-21 which was not improved by the 42-item version. Furthermore, the 21-item DASS provided clearer distinction between the anxiety and depression symptoms compared with the 42-item DASS. These results point to the value of DASS-21 as the instrument of choice over its 42-item counterpart. A Chinese version of DASS-21 was developed and tested on an Australian immigrant sample by Taouk et al (13). Factor loadings were found to be generally comparable to those reported by Lovibond and Lovibond using the English DASS (1,3), but the discrimination between the depression, anxiety and stress scales was significantly poorer. This study represents only a preliminary validation of the Chinese DASS-21, and the value of this translated measure in the Hong Kong population remains questionable, especially since there are subtle differences in the use of the Chinese language by Chinese in different parts of the world. Data from Chinese-speaking Australian immigrants cannot be readily generalizable to Hong Kong Chinese. Indeed, experience by local clinicians found parts of the scale poorly understood by some patients in Hong Kong. Further study is called for to formally translate the DASS-21 into Chinese, to test the psychometric properties of the Chinese version on a clinical sample, and to perform a more thorough evaluation of its psychometric properties among non-clinical samples of Hong Objectives of Study: This study aims to use a systematic and methodical approach to translate the DASS-21 into Chinese, and to validate it on non-clinical and clinical samples of Hong Kong Chinese. Specifically, the proposed study aims to achieve the following two main objectives: (i) To produce a conceptually and linguistically equivalent Chinese translation of the original English DASS- 21. (ii) To evaluate the psychometric properties of the Chinese DASS-21 among non-clinical and clinical populations in Hong Kong in terms of reliability, factorial validity, convergent and discriminant validity, and concurrent validity.


List of Research Outputs

Lee A.M., Antenatal Depression, Hong Kong Economic Daily (July 22, 2005). 2005, A26.
Lee A.M., Antenatal depression and anxiety, PHUDA Newsletter and Website. 2005.
Lee A.M., Eating Disorders and Self-Esteem Problems among Adolescents, Workshop for participants in the Hospital Authority-Jardine Health in Mind Youth Mental Health Promotion Programme on April 29. 2006.
Lee A.M., Emotional Arousal and Influenza Prevention, TVB Flu Education Programme (December 22, 2005). 2005.
Lee A.M., Interviewing Skills for Cervical Smear Taking, invitated lecture given to the Family Planning Association (audience: nurses) on May 20. 2006.
Lee A.M., Mental Health in Face of Potential Influenza Pandemic, TVB Flu Education Programme (December 23, 2005). 2005.
Lee A.M., Postpartum Depression, Hong Kong Economics Daily (August 13, 2005). 2005, A26.
Lee A.M., Wei R., Chung K.F., Hui K.T., Ip S.K., Leung H.L., Liu H.L., Lui S.Y., Ng Y.H., Wong M.F. and Wong T.C., Premenstrual Syndrome among Chinese female undergradutes: Relationship with stress and general mental health, Hong Kong Journal of Gynaecology, Obstetrics and Midwifery. 2005, 5: 10-21.
Lee A.M., Premenstrual Syndrome and Premenstrual Dysphoric Disorder, TVB Super Sun television interview (February 24, 2006). 2006.
Lee A.M., Premenstrual Syndrome: Assessment and Management, invited lecture given to the Department of Health (audience: doctors and nurses) on October 29. 2005.
Lee A.M., Lam S.K., Lau S.M. and Tang L.C.H., Prevalence and risk factors of antenatal anxiety and depression among Chinese pregnant women, Paper presented at the Conference on the Quality of Life Research in Asia (May 19-21, 2006). Hong Kong, 2006.
Lee A.M., Prevention Strategies in Face of Potential Influenza Pandemic, TVB Flu Education Programme (December 21, 2005). 2005.
Lee A.M., Prevention of Antenatal Depression, Hong Kong Economic Daily (August 3, 2005). 2005, C11.
Lee A.M., Prevention of Antenatal Depression, Oriental Daily (July 22, 2005). 2005, A22.
Lee A.M., Psychological aspects of menopause, PHUDA Newsletter and Website. 2005.
Lee W.Y., Chen R.Y.L., Chum K.W.C., Chau W.Y., Lee A.M., Chen E.Y.H., Tang S.W. and Sham P.C., Psychiatric comorbidity of substance use disorder and pathological gambling in Hong Kong Chinese, Paper presented at the Australian National Association for Gambling Studies (January 2006). 2006.
Leung S.K., Lee A.M., Salili F., Wong E. and Fung T., Premenstrual Syndrome and associated psychosocial variables among Chinese young adults in Hong Kong, 16th International Nursing Research Congress. Hawaii, 2005.
Tang V., Lee A.M., Chan C.L.W. and Ho J.W.C., The role of body image on psychological well- being among patients with colorectal cancer - a preliminary report, paper presented at the 18th Asian Pacific Social Work Conference (September 21-24, 2005). Korea, 2005.
Tang V.Y.H., Lee A.M., Chan C.L.W., Leung P.P.Y., Sham J.S.T., Ho J.W.C., Fu Y.T. and Yau T.K., The legend of posttraumatic growth: A preliminary report on the effectiveness of Body-Mind-Spirit (BMS) intervention on colorectal cancer survivors, Paper presented at the 12th Hong Kong International Congress (December 8-10, 2005), and awarded the Young Investigator Award 2005. Hong Kong.


Researcher : Lee PWH

Project Title:A study of risk factors for exposure to AIDS in high risk adolescent Chinese females
Investigator(s):Lee PWH, Lin O.C., Fung A.S.M.
Department:Psychiatry
Source(s) of Funding:Council for the AIDS Trust Fund - General Award
Start Date:04/1997
Abstract:
To study the prevailing pattern of knowledge, practice and attitudes towards sexual intimacy and behaviours in teenage secondary school female students; to study common misconceptions and risks of teenage secondary school students towards developing STDs and AIDs; to study factors associated with increased risk for exposure to STDs and AIDs.


Project Title:Psychological adjustment and stresses of nurses working in acute hospital
Investigator(s):Lee PWH
Department:Psychiatry
Source(s) of Funding:Other Funding Scheme
Start Date:06/1997
Abstract:
To study the prevalence of psychological malaise in a representative group of registered nurses working in acute general hospital; to identify factors associated with increases stress and strain in registered nurses in acute general hospital.


Project Title:The psychosocial outcomes and well-being of living related donors involved in liver transplantation surgery: a follow-up study of risk factors, resilience, and outcome predictors
Investigator(s):Lee PWH, Fan ST, Fung ASM
Department:Psychiatry
Source(s) of Funding:Small Project Funding
Start Date:11/2003
Abstract:
To trace the natue and course of psycholsocial adjustment of living related donors through a retrospective study on their adjustment in the pre-transplanation, post-transplantation and rehabilitation phases; to identify areas of concerns, difficulties, physical malaise, and psychosocial distress in donors during the different phases of the transplantation procedure and its rehabilitation; to study the relationship between pre-transplantation variables of the living related donors and their levels of post-transplantation functioning and adjustment; to identify predictors of high-risk characteristics and situations likely to be encountered by living related donors and consider ways of reducing such risks; on the basis of data gathered and analyzed, to consider cost-effective avenues, format and focus of psychosocial interventions to enable potential living related donors to achieve an all round better immediate and long-term outcome; to look into the differences in decision making processes and adjustment of living related donors with different relationship with the recipients.


List of Research Outputs

Chan Y.M., Lee P.W.H., Fong D.Y.T., Fung A.S.M., Wu L.Y.F., Choi A.Y., Ng T.Y., Ngan H.Y.S. and Wong L.C., Effect of individual psychological intervention in Chinese women with gynecologic malignancy: A randomized controlled trial, Journal of Clinical Oncology. 2005, 23(22): 4913-4924.
Lee P.W.H., Dealing with unhappy patient, Orthopaedic Forum 2006. 2006.
Lee P.W.H. and Kwan T.T.C., Death, dying and bereavement: a Hong Kong Chinese experience, In: C.L.W. Chan and A.Y.M. Chow (Eds.) , Providing end-of-life care: enhancing effectiveness and resilience . HKU Press, 2006, 209-224.
Lee P.W.H., Stewart S.M. and Chan K.K.C., Hong Kong, SAR China: transitions and return to the motherland, In: James Georgas, John W Berry, Fons J R van de Vijver, Cigdem Kagitcibasi, and Ype H Poortinga, Families Across Cultures, A 30-Nation Psychological Study. Cambridge University Press, 2006, 353-361.
Lee P.W.H., Psychogenic Pain, International Conference on Applied Psychology. 2005.
Lee P.W.H., Psychological Management of Epileptic Patient and Relatives, Enlighten - Workshop on Epilepsy given to 15 Epileptic patient and relatives. 2005.
Lee P.W.H., Stress Management and Staff Support, ICAC: Chief Investigators' Command Course. 2005.
Lee P.W.H., Workshop on Psychological Care for Diabetic Patients, Post-registration Certificate Course in Diabetes Nursing. 2005.
Lee W., Lam T.H., Stewart S.M., Ho D.S.Y., Leung G.M., Lee S., Mak K.H., Lee P.W.H., Wong P.S.J. and Striegel-Moore R.H., A population-based, longitudinal study of eating disturbances in Hong Kong Chinese boys and girls: Results from a pilot study (Abstract), 10th Research Postgraduate Symposium, 3 December 2005, Hong Kong. Hong Kong, Faculty of Medicine, University of Hong Kong, 2005, 87.
Lee W., Lam T.H., Stewart S.M., Ho D.S.Y., Leung G.M., Lee S., Mak K.H., Lee P.W.H., Wong J.P.S. and Striegel-Moore R.H., Pilot study findings from "A population-based, longitudinal study of eating disturbances in Hong Kong Chinese boys and girls", Hong Kong College of Community Medicine Annual Scientific Meeting, 25 June 2006, Hong Kong. Hong Kong, Hong Kong College of Community Medicine, 2006, Poster 11.


Researcher : Lee TMC

Project Title:Memory deficits following unilateral frontal or temporal brain lesion
Investigator(s):Lee TMC, Fan YW
Department:Psychology
Source(s) of Funding:Health Services Research Fund - Full Grants
Start Date:05/2000
Abstract:
To develop an instrument for assessment of confabulation in prose memory.


Project Title:Deception and its detection: brain activities associated with faking memory problems
Investigator(s):Lee TMC, Broadhurst RG, Yang ES, Liu AHL, Gao JH, Fox PT
Department:Psychology
Source(s) of Funding:Competitive Earmarked Research Grants (CERG)
Start Date:08/2002
Abstract:
The project attempts to investigate the potential application of brain activities to understand the phenomenon of deception and its detection. It will examine the generalizability of forced-choice testing situations, and also different brain activities associated with making genuine errors and feigning memory impairment.


Project Title:The effect of emotional attachment on the brain activities associated with deception: an functional magnetic resonance imaging (fMRI) study
Investigator(s):Lee TMC
Department:Psychology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2005
Completion Date:11/2006
Abstract:
The study is intended to investigate the role of emotional attachment on the brain activity patterns that are associated with deception.


Project Title:Selective attention biases of people with major depressive disorder, and its relationship with brain damages.
Investigator(s):Lee TMC, Leung K.K.
Department:Psychology
Source(s) of Funding:Small Project Funding
Start Date:09/2005
Abstract:
Attention bias towards mood-congruent information has been postulated to be one of the essential psychological substrates of major depressive disorder. Attention biases could have at least two levels of meanings: a) initial orienting, i.e. attention being captured involuntarily to certain types of information; and b) difficulties in inhibiting or shifting the attention from the current attentional focus once certain types of information has been attended to, either voluntarily or involuntarily. However, research findings are inconsistent in demonstrating these phenomena in people with major depressive disorder. This study aims to investigate whether people with major depressive disorder exhibit these two types of attention biases. In addition, it has been postulated that major depressive disorder is associated with frontal-limbic dysregulation. In particular, various studies suggest that amygdala, prefrontal cortex, anterior cingulate cortex, and hippocampus are involved in depression. This study also attempts to investigate whether people with brain lesions arising from stroke or brain trauma at the above areas also exhibit the attention biases to depression-related information. It also follows that question of whether those who show these attention biases due to brain lesions also exhibit depressive features will also be examined.


List of Research Outputs

Lau W.M., Qiu G., Helmeste D.M., Lee T.M.C., Tang S.W. and So K.F., Corticosteroid decreases subventricular zone cell proliferation, which could be reserved by paroxetine, Restorative Neurology and Neuroscience (In press). 2006.
Lee T.M.C., Chan M.W.C., Gao J.L., Chen E.Y.H., Wang K. and Chan C.C.H., The nature of prose memory deficits associated with schizophrenia, Schizophrenia Research. 2006, 81: 199-209.


Researcher : Lee WY

List of Research Outputs

Lee W.Y., Chen R.Y.L., Chum K.W.C., Chau W.Y., Lee A.M., Chen E.Y.H., Tang S.W. and Sham P.C., Psychiatric comorbidity of substance use disorder and pathological gambling in Hong Kong Chinese, Paper presented at the Australian National Association for Gambling Studies (January 2006). 2006.


Researcher : Leung PWL

List of Research Outputs

Cheung V., Cheung C., Sham P.C., Leung P.W.L., Khong P.L., Chua S.E., Chen E.Y.H. and McAlonan G.M., Relationship between volumetric structural abnormalities and white matter dysconnectivity in never-medicated patients with first-episode psychosis , 12th. Annual Meeting Human Brain Mapping. Florence, Italy, 2006.


Researcher : Mak KY

Project Title:Program enhancement for the mental-ill patients at the S.K. Yee Mental Health Resource and Rehabilitation Centre
Investigator(s):Mak KY, Wong MMC, Mak-Lieh F, Yau EFY, Yip E.C.H.
Department:Psychiatry
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:09/2000
Abstract:
To facilitate psychiatric patients to return to work and re-integrate into society through widening the present service scope by providing sufficient equipment to meet the increasing demand in work training and offer wider range of therapeutic programs to improve the domestic living skill of patients; to provide professional development and training to psychiatrists and paramedical staff in Hong Kong and China.


List of Research Outputs



Researcher : Mak-Lieh F

List of Research Outputs

Chua S.E., Cheung C., McAlonan G.M., Lam I.W.S., Cheung V., Wong K.W.T., Chan E.K.C., Mak-Lieh F., Tai K.S., Yip L.K.C. and McGuire P.K., Functional Magnetic Resonance Imaging Evaluation of Bilateral Brain Activation in Chinese Speech, Hong Kong Journal of Psychiatry. 2006, 15(2): 77-81.
Wong J.G.W.S., Patil N.G., Beh S.L., Cheung E.P.T., Wong V., Chan L.C. and Mak-Lieh F., Cultivating psychological well-being in Hong Kong's future doctors, Medical Teacher. 2005, 27(8): 715-9.


Researcher : McAlonan GM

List of Research Outputs

Cheung C., Cheung V., Qiu D.Q., Leung L.H.T., Khong P.L., Chen E.Y.H., Chua S.E. and McAlonan G.M., Diffusion tensor imaging study of periventricular and cortico-cortical white matter dysconnectivty in never-medicated schizophrenia, 13th Biennial Winter workshop on Schizophrenia, Schizophrenia Research. Davos, Seitzerland, 2006, 81: 156.
Cheung J.P.Y., Cheung V., Cheung C., Chen E.Y.H., Tsang J.T.K., Wong J.C.H., Yip L., Tai K.S., Suckling J., Bullmore E., McAlonan G.M. and Chua S.E., A comprehensive computational morphometric analysis of the brain in neuroleptic-naïve schizophrenia, Schizophrenia Research. 2006, 81: 165.
Cheung J.P.Y., Cheung V., Cheung C., Chen E.Y.H., Tsang J.T.K., Wong J.C.H., Yip L., Tai K.S., Suckling J., Bullmore E., McAlonan G.M. and Chua S.E., Early striatal & extrastriatal cerebral grey matter excess within 3 weeks of anti-psychotic treatment in schizophrenia, 13th Biennial Winter Workshop on Schizophrenia, Schizophrenia Research. Davos, Switzerland, 2006, 81: 156.
Cheung V., Cheung C., Sham P.C., Leung P.W.L., Khong P.L., Chua S.E., Chen E.Y.H. and McAlonan G.M., Relationship between volumetric structural abnormalities and white matter dysconnectivity in never-medicated patients with first-episode psychosis , 12th. Annual Meeting Human Brain Mapping. Florence, Italy, 2006.
Cheung V., Cheung C., Qiu D.Q., Khong P.L., Chen E.Y.H., McAlonan G.M. and Chua S.E., White matter dyconnectivity of cortico-stratal areas and the relation with executive functioning in never-medicated patients with first-episode psychosis, 12th. Annual Meeting Human Brain Mapping. Florence, Italy, 2006.
Chua S.E., Cheung C., McAlonan G.M., Lam I.W.S., Cheung V., Wong K.W.T., Chan E.K.C., Mak-Lieh F., Tai K.S., Yip L.K.C. and McGuire P.K., Functional Magnetic Resonance Imaging Evaluation of Bilateral Brain Activation in Chinese Speech, Hong Kong Journal of Psychiatry. 2006, 15(2): 77-81.
Chua S.E. and McAlonan G.M., 腦部社交區變異與自閉症的關係 (健康情報), Metropoplis Daily. 都巿日報, 香港, 都巿日報, 2005, 32.
Khong P.L., Leung L.H.T., Fung A.S.M., Fong D.Y.T., Qiu D., Kwong D.L.W., Ooi C.G.C., McAlonan G.M., Cao G. and Chan G.C.F., White Matter Anisotropy in Post-Treatment Childhood Cancer Survivors: Preliminary Evidence of Association With Neurocognitive Function, Journal of Clinical Oncology. 2006, 24(6): 884-890.
Khong P.L., Qiu D., Yung A.W.Y., Poon G.W.K., Leung C., Chua S.E., McAlonan G.M. and Lam B.C.C., White matter volume and anisotropy in very low birth weight preterm born children: association with cognitive outcome, 14th Scientific Meeting & Exhibition, Seattle, Washington, USA, 6-12 May 2006.
McAlonan G.M. and Chua S.E., HKU Autism Research Finds Changes in Brain Regions which Control Social Ability, Apple Daily. 2005, A24.
McAlonan G.M. and Chua S.E., HKU Autism Research Finds Changes in Brain Regions which Control Social Ability, Hong Kong Daily News. 2005, A8.
McAlonan G.M. and Chua S.E., HKU Autism Research Finds Changes in Brain Regions which Control Social Ability, Hong Kong Economic Times. 2005, A29.
McAlonan G.M. and Chua S.E., HKU Autism Research Finds Changes in Brain Regions which Control Social Ability, Ming Pao. 2005, A16.
McAlonan G.M. and Chua S.E., HKU Autism Research Finds Changes in Brain Regions which Control Social Ability, Oriental Daily. 2005, A39.
McAlonan G.M. and Chua S.E., HKU Autism Research Finds Changes in Brain Regions which Control Social Ability, Sing Tao. 2005, A9.
McAlonan G.M. and Chua S.E., HKU Autism Research Finds Changes in Brain Regions which Control Social Ability, The Sun. 2005, A31.
McAlonan G.M. and Chua S.E., HKU Autism Research Finds Changes in Brain Regions which Control Social Ability, Wen Wei Po. 2005, A14.
McAlonan G.M. and Chua S.E., Learning to understand autism, HKU Bulletin. 2006, Apr vol 7: no. 5, 11.
Wong J.C.H., Cheung V., Cheung C., Chen E.Y.H., Tsang J.T.K., Yip L., Tai K.S., Suckling J., Bullmore E., McAlonan G.M. and Chua S.E., Bilateral caudate volume deficits in never-treated schizophrenia, 13th Biennial Winter Workshop On Schizophrenia, Schizophrenia Research. Davos, Switzerland, 2006, 81: 167.


Researcher : Miao YK

List of Research Outputs

Chen E.Y.H., Hui L.M.C., Wong C.K., Dunn E.L.W., Chan W.F., Miao Y.K., Yeung W.S. and Tang O.W.N., Long duration of untreated psychosis is associated with poorer neurocognitive and negative symptom recovery after first episode schizophrenia, Schizophrenia Research. 2006, 81: 231.
Hui L.M.C., Chen E.Y.H., Wong C.K., Dunn E.L.W., Chan W.F., Miao Y.K., Yeung W.S. and Tang O.W.N., The course of semantic memory dysfunction in first-episode schizophrenia, Schizophrenia Research. 2006, 81: 111.


Researcher : Ng ML

Project Title:Chaos in psychotherapy
Investigator(s):Ng ML, Xu C.J.
Department:Psychiatry
Source(s) of Funding:Department of Psychiatry - General Award
Start Date:09/1998
Abstract:
To look for chaos patterns in the communication procedures in psychotherapy using mathematical or physical modelling.


Project Title:Violence on male genitalia - a ten year review of cases in Hong Kong
Investigator(s):Ng ML, Cheb C., Lai S., Ho R.
Department:Psychiatry
Source(s) of Funding:Other Funding Scheme
Start Date:05/2002
Abstract:
To review and investigate into the demographic, psychological and social characteristics of the victims and the offenders involved in cases of violent male genital injury in the last ten years in Hong Kong.


List of Research Outputs

Ng M.L., Chen R.Y.L. and Lee W.Y., Attitude, Behavior and Psychophysiological Responses to Gambling in Chinese Macau Gambling Workers, Inaugural Asian Pacific Problem Gambling Conference (2005-11- 23). 2005, 37-38.
Ng M.L., Demystifying Sex, Students' Affair Office, Macau University. Macau, 2006.
Ng M.L., Era of Affection and Sex Counseling in Hong Kong, Richmond Fellowship of Hong Kong and Florida Postgraduate Sex Therapy Training Institute. 2006.
Ng M.L., Psychological Aspects of Sexual Dysfunction (Abstract), Beijing/ Hong Kong Medical Exchange Seventh Meeting-AIDS & Sexual Health (Sep 26-27). Beijing, Chinese Medical Association, Hong Kong Medical Association, 2005, 35.
Ng M.L., Psychosexual Disorders, In: Chiu EYK and Chiu HFK, Textbook in Psychiatry for Asia. Beijing, Peking University Medical Press, 2006, Chapter 13: 102-108.
Ng M.L., Lee G.M.Y. and Ng T.M.Y., Special Publication of the First Hong Kong Sex Cultural Festival 2006. 香港首屆性文化節2006特刊, Hong Kong, Hong Kong Sex Education Association, 2006.
Ng M.L., Kuriansky J., Ng T.M.Y., Shen S.M. and Cheung B., The Web-based Sex Education for Professionals in Hong Kong, Youth Sexual Health Education Conference-Global Perspectives Papers (Oct 12-14). Hangzhou China, China Sexology Association, 2005, 52-57.
Ng M.L., Kuriansky J., Ng T.M.Y. and Cheung B.S.N., The evaluation of a web-based course for professional sex education in Hong Kong, The 28th Congress of the World Federation for Mental Health, Equity and Mental Health. Cairo, 2005.
Ng M.L., The politics of sexual harassment, 性騷擾背後的性政治, Proceedings of the First Annual Conference of the Taiwan Sexology Association (Nov 24). 台灣性學會第一屆年會、會員大會暨學術研討會 (11月24日), 台灣高雄, 台灣性學會, 2005, 23-26.
Ng M.L. and Ko S.N., The state and development of sexual disorder services in Hong Kong, Proceedings of First China International Forum on Sexual Medicine (Oct 21-23). Chongqing China, China Sexology Association, 2005, 22-25.
Ng M.L., The transformation of a sexual culture, the Chinese paradigm, Editorial, Sexual and Relationship Therapy. 2006, 21:2: 137-141.
Ng M.L., 性騷擾背後的性政治, 第一屆台灣性學會週年會議, Kaohsiung, Taiwan, 2005.


Researcher : Ran M

Project Title:A long-term prospective follow-up study of suicide among persons with affective disorders in a chinese rural area
Investigator(s):Ran M, Chan CLW, Yip PSF, Chen EYH
Department:Social Sciences Faculty
Source(s) of Funding:Small Project Funding
Start Date:11/2004
Abstract:
To explore the characteristics of suicide among 196 individuals with affective disorders in a 10-year prospective follow-up study in a Chinese rural community.


List of Research Outputs

Ran M., Chan C.L.W., Chen E.Y.H., Mao W.J., Hu S.H., Tang C.P., Lin F.R. and Conwell Y., The influence of caregivers on treatment of patients with schizophrenia in rural China, Schizophrenia Research. 2006, 81: 63.


Researcher : Sham PC

Project Title:An association screen for schizophrenia susceptibility loci in a high-LD, gene-rich region of chromosome 3p
Investigator(s):Sham PC
Department:Psychiatry
Source(s) of Funding:Small Project Funding
Start Date:07/2004
Abstract:
To identify novel susceptibility loci for schizophrenia, by conducting a high-density SNP screen of a region recently identified by a meta-analysis of 20 genome-wide linkage scans.


Project Title:A systematic screen for schizophrenia susceptibility loci in high-LD, gene-rich chromosomal regions implicated by meta-analysis of whole genome linkage scans
Investigator(s):Sham PC
Department:Psychiatry
Source(s) of Funding:Merit Award for RGC CERG Funded Projects
Start Date:01/2006
Abstract:
N/A


Project Title:A systematic screen for schizophrenia susceptibility loci in high-LD, gene-rich chromosomal regions implicated by meta-analysis of whole genome linkage scans
Investigator(s):Sham PC, Chen RYL, Ng KP, Li T
Department:Psychiatry
Source(s) of Funding:Competitive Earmarked Research Grants (CERG)
Start Date:01/2006
Abstract:
To identify novel susceptibility loci for schizophrenia, by conducting a high-density SNP screen of a number of chromosomal regions that are (a) identified as linkage hotspots by a recent meta-analysis of 20 genome-wide scans of schizophrenia, (b) gene-rich and (c) high in the level of linkage disequilibrium (LD). Optimal marker sets that tag all common variation in these regions will be selected using HapMap data on the Chinese population. These regions will be screened in 489 cases of DSM-IV schizophrenia and 520 controls recruited from Hong Kong; significant associations will be replicated on 500 cases and both parents recruited from Chengdu.


List of Research Outputs

Cheung K.M.C., Chen Y., Karppinen J., Chan D., Jim J.J.T., Luk K.D.K., Ala-Kokko L., Leong J.C.Y., Ott J., Sham P.C., Cheah K.S.E. and Song Y., Association of the Taq I allele in vitamin D receptor with degenerative disc disease and disc bulge in Chinese, Spine. 2006, 31(10): 1143-8.
Cheung K.M.C., Jim J.J.T., Noponen-Hietala N., Ott J., Karppinen J., Sahraravand A..., Luk K.D.K., Yip S...P., Sham P.C., Song Y., Leong J.C.Y., Cheah K.S.E., Ala-Kokko L. and Chan D., The Genetics of intervertebral disc degenertation, European Cells and Material: ECM VI/SRN I Spinal Motion Segment: From basic science to clinical application. Davos, Switzerland, July . 2005.
Cheung V., Cheung C., Sham P.C., Leung P.W.L., Khong P.L., Chua S.E., Chen E.Y.H. and McAlonan G.M., Relationship between volumetric structural abnormalities and white matter dysconnectivity in never-medicated patients with first-episode psychosis , 12th. Annual Meeting Human Brain Mapping. Florence, Italy, 2006.
Jim J.J.T., Noponen-Hietala N., Cheung K.M.C., Ott J., Karppinen J., Sahraravand A., Luk K.D.K., Yip S.P., Sham P.C., Song Y., Leong J.C.Y., Cheah K.S.E., Ala-Kokko L. and Chan D., The TRP2 allele of COL9A2 is an age-dependent risk factor for the development and severity of intervertebral disc degeneration, Spine. 2005, 30: 2735-2742.
Khoo U.S., Chan V.S.F., Chan Y.K., Chen Y., Poon L.L.M., Cheung A.N.Y., Zheng B., Ngan H.Y.S., Tam P.K.H., Chan L.C., Yip S.P., Peiris J.S.M., Sham P.C. and Lin C.L., The protective role of homozygous L-SIGN (CLEC4M) in SARS coronavirus infection., HUGO's 11th Human Genome Meeting, Helsinki, Finland. . 2006.
Kung A.W.C., Lai M.H., Ng M.Y.M., Cheung W.M.W., Chan V.N.Y. and Sham P.C., Estrogen receptor beta polymorphisms predict risks of osteoporosis in men and women: A linkage and association study, 27th Annual Meeting of the American Society for Bone & Mineral Research, 23-27 September 2005, Nashville, USA. 2005.
Kung A.W.C., Lai M.H., Ng M.Y.M., Chan V.N.Y. and Sham P.C., T-1213C polymorphism of estrogen receptor beta is associated with low bone mineral density and osteoporotic fractures, Bone. 2006.
Lau H.L., Ng M.Y.M., Cheung W.M.W., Paterson A.D., Sham P.C., Luk K.D.K., Chan V.N.Y. and Kung A.W.C., Assessment of linkage and association of 13 genetic loci with bone mineral density, Journal of Bone and Mineral Metabolism. 2006, 24: 226-34.
Lau H.L., Ng M.Y.M., Jin L., Paterson A., Sham P.C., Luk K.D.K., Chan V.N.Y. and Kung A.W.C., Test of linkage and association of 14 genetic loci with bone size, 27th Annual Meeting of the American Society for Bone & Mineral Research, 23-27 September 2005, Nashville, USA. 2005.
Lee W.Y., Chen R.Y.L., Chum K.W.C., Chau W.Y., Lee A.M., Chen E.Y.H., Tang S.W. and Sham P.C., Psychiatric comorbidity of substance use disorder and pathological gambling in Hong Kong Chinese, Paper presented at the Australian National Association for Gambling Studies (January 2006). 2006.
Song Y., Ho D.W.H., Cheung K.M.C., Karppinen J., YIP S...P., Leong J.C.Y., Ott J., Luk K.D.K., Cheah K.S.E., Sham P.C. and Chan D., Genetic Linkage analysis of early onset degenerative disc disease in Southern Chinese., HUGO Pacific meeting & Asia-pacific Human Genetics Conference (HUGO-AP 2006), March 6-10, 2006 Academica Sinica, Taipei. 2006.
Tang L.F., Chan S.Y., Sham P.C. and Song Y., In silico mapping of quantitative trait loci affecting bone mineral density in mice., HUGO Pacific meeting & Asia-Pacific Human Genetics Conference (HUGO-AP 2006) March 6-10,2006 Academica Sinica, Taipei. 2006.
The International HapMap Consortium &., Tsui L.C., Mak W.W., Sham P.C., Song Y. and Tam P.K.H., A haplotype map of the human genome. The International HapMap Consortium (Co-PI of Hong Kong Centre which responsible 2.5% of genome), Nature. 2005, 437: 1299-1319.
The International HapMap Consortium H.K.U., Tsui L.C., Mak W.W., Sham P.C., Song Y. and Tam P.K.H., A haplotype map of the human genome (Co-PI of Hong Kong Centre which responsible for 2.5% of genome), Nature. 2005, 437: 1299-1320.
Tse Y.T., Chan Y.K., Chan S.Y., Tsang S.T.Y., Sham P.C. and Khoo U.S., Estrogen Receptor a Gene Polymorphisms and Breast Cancer Risk in Chinese, HUGO's 11th Human Genome Meeting, Helsinki, Finland. . 2006.
Tsui L.C., Mak W., Sham P.C., Song Y. and Tam P.K.H., Haplotype Map of the Human Genome, Nature . 2005, 437: 1299-1320.


Researcher : So KF

Project Title:Molecular signaling of PKR/EiF2-[alpha] and GSK3[beta] in the pathophysiology of glaucoma
Investigator(s):So KF, Hugon J, Chang RCC
Department:Anatomy
Source(s) of Funding:Incentive Award for RGC CERG Fundable But Not Funded Projects
Start Date:07/2003
Abstract:
N/A


Project Title:The effect of CNTF and BDNF on retinal ganglion cell survival and nitric oxide expression after optic nerve injury
Investigator(s):So KF
Department:Anatomy
Source(s) of Funding:Small Project Funding
Start Date:11/2004
Completion Date:02/2006
Abstract:
To investigate the importance of different types of neurotrophic factors on the survival of retinal ganglion cells and their relationship to the expression of nitric oxide.


Project Title:Neuroprotection in steroid therapy: an animal model
Investigator(s):So KF, Lee TMC, Tang SW
Department:Anatomy
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:01/2005
Abstract:
To investigate the effect of Lithium and paroxetine in arresting hippocampal damages associated with high dosage of steroid through quantitative neuro-anatomical and immunohistochemical methods.


Project Title:The role of KhcU on the development and intracellular transportation of rod bipolar cell of mice retina
Investigator(s):So KF, Huang J
Department:Anatomy
Source(s) of Funding:Small Project Funding
Start Date:10/2005
Completion Date:09/2006
Abstract:
In this study, we make use of the previously created Pcp2-IRES-Cre mouse line and knock out the ubiquitously expressed kinesin heavy chain (KhcU) specifically in rod bipolar cells. We aim to investigate: 1) the retinal phenotypic and developmental changes after KhcU knockout in rod bipolar; 2) the alterations of intracellular transportation in the absence of KhcU, the MyosinVa-mediated processes will be specially noted.


List of Research Outputs

Lau W.M., Qiu G., Helmeste D.M., Lee T.M.C., Tang S.W. and So K.F., Corticosteroid decreases subventricular zone cell proliferation, which could be reserved by paroxetine, Restorative Neurology and Neuroscience (In press). 2006.


Researcher : Tang OWN

List of Research Outputs

Chen E.Y.H., Hui L.M.C., Wong C.K., Dunn E.L.W., Chan W.F., Miao Y.K., Yeung W.S. and Tang O.W.N., Long duration of untreated psychosis is associated with poorer neurocognitive and negative symptom recovery after first episode schizophrenia, Schizophrenia Research. 2006, 81: 231.
Hui L.M.C., Chen E.Y.H., Wong C.K., Chan W.F. and Tang O.W.N., The course of semantic memory dysfunction in first-episode schizophrenia: a prospective 3-year longitudinal study, 13th Biennial Winter Workshop on Schizophrenia Research. Davos, 2006.
Hui L.M.C., Chen E.Y.H., Wong C.K., Dunn E.L.W., Chan W.F., Miao Y.K., Yeung W.S. and Tang O.W.N., The course of semantic memory dysfunction in first-episode schizophrenia, Schizophrenia Research. 2006, 81: 111.


Researcher : Tang SW

List of Research Outputs

Huang Y. and Tang S.W., Commentary on Allik: Cross-Cultural Diagnosis of Personality Disorders, Dimensional Models of Personality Disorders: Refining the Research Agenda for DSM-V. Washington, DC, American Psychiatric Association, 2006, Chapter 15: 143-147.
Lau W.M., Qiu G., Helmeste D.M., Lee T.M.C., Tang S.W. and So K.F., Corticosteroid decreases subventricular zone cell proliferation, which could be reserved by paroxetine, Restorative Neurology and Neuroscience (In press). 2006.
Lee A.C.K., Tang S.W. and Yu G.K.K., Depression After Stroke: A Triple Burden, 9 th Asian Regional Conference of CICIAMS . Hong Kong, Hong Kong Catholic Nurses Guild, 2005, 101.
Lee W.Y., Chen R.Y.L., Chum K.W.C., Chau W.Y., Lee A.M., Chen E.Y.H., Tang S.W. and Sham P.C., Psychiatric comorbidity of substance use disorder and pathological gambling in Hong Kong Chinese, Paper presented at the Australian National Association for Gambling Studies (January 2006). 2006.
Qiu G., Lee T.M.C., Helmeste D.M., Tang S.W. and So K.F., The modulation of paroxetine to the suppressive effect of corticosteroid on adult hippocampal neurogenesis, Society for Neuroscience 2005. Program No. 552.3.
Tang S.W., Applied Molecular Psychophamacology for the Psychiatrists, Talk to Castle Peak Hospital, January 18, 2006. 2006.
Tang S.W. and Helmeste D.M., Aripiprazole, Medical Progress. 2006, 33, No.2: 84-88.
Tang S.W., CINP Technical Review on the Usefulness and Use of Anti-Depressant Medications, Talk to CINP Technical Review of Anti-Depressant Medications, Regional Meeting, Shanghai, China, June 26-27, 2006. Shanghai, China, 2006.
Tang S.W. and Helmeste D.M., Duloxetine, Medical Progress. 2006, 33, No.3: 136-140.
Tang S.W., Escitalopram-Basic Mechanism of Action, Key speaker, at the Chinese Psychiatrists, Psychophamacology, Shanghai , China, April 21, 2006. Shanghai, China, 2006.
Tang S.W., Escitalopram-Basic Mechanism of Action, Key speaker, at the Manila Philippine Psychiatric Association, Philippine, March 3, 2006. Philippine, 2006.
Tang S.W., Escitalopram-what is special about the molecule, Talk to Asian Expert Meeting, Perth, Australia, November 18, 2005. 2005.
Tang S.W., How Psychiatric Drug Works, Breaking News, Speaker at the Macau Psychiatric Association, December 16, 2005. 2005.
Tang S.W., International Training in Psychopharmacology, Certificate Program (Organizer) (2005-Present). 2006.
Tang S.W., Key speaker and Organizing Committee member International Conference on Pharmacogenetics IUPHAR & PRACP, June 28-30, 2006. Changsha, China, 2006.
Tang S.W., Member and Speaker, CINP Technical Review of Anti-Depressant Medications, Regional Meeting, Shanghai, China, June 26-27, 2006. Shanghai, China, 2006.
Tang S.W., Neurotransmitters in a changing Brain, Gust speaker for the Hong Kong Society of Child Neurology and Development Paediatrics, Queen Elizabeth Hospital, Kowloon, July 29, 2005. 2005.
Tang S.W., New Technology in Drug Discovery and Development, Key speaker at the International Conference on Phamacogenetics IUPHAR & PRACP, Changsha, China, June 28-30, 2006. Changsha, China, 2006.
Tang S.W., 每年一次情緒健康檢查, Talk to Metro Finance Radio-Public Education Programme, September 30, 2005. 2005.
Tang S.W., 每年一次情緒健康檢查, Talk to Sanatorium Hospital October 18, 2005. 2005.
Tang S.W., Treating Depression in Old Age, Talk to HKW Cluster Geriatric Academic Meeting, Queen Mary Hospital, October 3, 2005. 2005.
Tang S.W., Treating Mood Problems in old age, Talk to Geriatric Academic Meeting, Queen Mary Hospital, September 5, 2005. 2005.
Tang S.W., UNO Magazine interview; Depression in Males (April 10, 2006). 2006.
Tang S.W. and Helmeste D.M., www Bioinformatics Resources, Pharmacogenomics. New York London, Taylor & Francis, 2005, 156: 493-514.
Tang S.W., TVB Health Program: 腦細胞可以再生嗎 (March 24, 2006), 2006.
Wong J.G.W.S., Cheung E.P.T., Chan K.K.C., Ma K.K.M. and Tang S.W., Web-based survey of depression, anxiety and stress in first-year tertiary education students in Hong Kong., Australian and New Zealand Journal of Psychiatry. 2006, 40: 777-782.
Wong N.L., Tsang S. and Tang S.W., SSRI Induced Hyponatraemia in non-geriatric psychiatric patients, Canadian Medical Association Journal. CMA Media Inc., 2006, 159 (10): 1245-1252.


Researcher : Wong CK

List of Research Outputs

Chen E.Y.H., Hui L.M.C., Wong C.K., Dunn E.L.W., Chan W.F., Miao Y.K., Yeung W.S. and Tang O.W.N., Long duration of untreated psychosis is associated with poorer neurocognitive and negative symptom recovery after first episode schizophrenia, Schizophrenia Research. 2006, 81: 231.
Hui L.M.C., Chen E.Y.H., Wong C.K., Chan W.F. and Tang O.W.N., The course of semantic memory dysfunction in first-episode schizophrenia: a prospective 3-year longitudinal study, 13th Biennial Winter Workshop on Schizophrenia Research. Davos, 2006.
Hui L.M.C., Chen E.Y.H., Wong C.K., Dunn E.L.W., Chan W.F., Miao Y.K., Yeung W.S. and Tang O.W.N., The course of semantic memory dysfunction in first-episode schizophrenia, Schizophrenia Research. 2006, 81: 111.


Researcher : Wong JGWS

Project Title:What makes a good clinical teacher in the new medical curriculum? A focus group study on student perception
Investigator(s):Wong JGWS, Lam TP, Mak-Lieh F
Department:Psychiatry
Source(s) of Funding:Other Funding Scheme
Start Date:01/2002
Abstract:
To examine medical student perceptions on what makes a good clinical teacher; to explore the concept of a good role model.


Project Title:A follow-up study on the severity of psychological sequelae in SARS patients
Investigator(s):Wong JGWS, Sham PC, Wong PC, McAlonan GM, Chu CM, Lee AM, Lee PWH, Tsang KWT, Chua SE
Department:Psychiatry
Source(s) of Funding:Small Project Funding
Start Date:11/2004
Abstract:
To assess severity of psychological sequelae in SARS patients (including infected HCWS after recovery from the infection; to assess severity of psychological sequelae in high risk and low risk HCWs after the SARS outbreak; to inform psychological intervention in the event of a future outbreak.


List of Research Outputs

Law C.W., Chen E.Y.H., Cheung E.F.C., Chan R.C.K., Wong J.G.W.S., Lam C.L.K., Leung K.F. and Lo M.S.M., Impact of Untreated Psychosis on Quality of Life in Patients with First-episode Schizophrenia, Quality of Life Research. 2005, 14: 1803-1811.
Wong J.G.W.S., Patil N.G., Beh S.L., Cheung E.P.T., Wong V., Chan L.C. and Mak-Lieh F., Cultivating psychological well-being in Hong Kong's future doctors, Medical Teacher. 2005, 27(8): 715-9.
Wong J.G.W.S., Cheung E.P.T., Chan K.K.C., Ma K.K.M. and Tang S.W., Web-based survey of depression, anxiety and stress in first-year tertiary education students in Hong Kong., Australian and New Zealand Journal of Psychiatry. 2006, 40: 777-782.


Researcher : Wong KWT

List of Research Outputs

Chua S.E., Cheung C., McAlonan G.M., Lam I.W.S., Cheung V., Wong K.W.T., Chan E.K.C., Mak-Lieh F., Tai K.S., Yip L.K.C. and McGuire P.K., Functional Magnetic Resonance Imaging Evaluation of Bilateral Brain Activation in Chinese Speech, Hong Kong Journal of Psychiatry. 2006, 15(2): 77-81.


Researcher : Wong MMC

Project Title:Enrichment of collections in the library of the S.K. Yee Mental Health Resources and Rehabilitation Centre
Investigator(s):Wong MMC, Mak KY, Mak-Lieh F, Yau EFY
Department:Psychiatry
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:10/2001
Abstract:
Taking care of mentally people in the community is often a great stress to the caregivers (including family members and staff of those agencies which are involved in the rehabilitation of the patients in the community). They often lack the knowledge in mental illness and are not equipped with the skills in taking care of the mentally ill patients. Therefore apart from offering services to the patients, the service should be extended to cover the caregivers. They should have easy access to information (including written and audio-visual material) so that they can have better knowledge on mental illness and can learn the skills in taking care of the mentally ill patients. It is also important to help the public to change their attitude towards the mentally ill through various public education materials which improve their awardness, understanding and acceptance of mental illness in the community.


List of Research Outputs



Researcher : Wu LYF

List of Research Outputs

Chan Y.M., Lee P.W.H., Fong D.Y.T., Fung A.S.M., Wu L.Y.F., Choi A.Y., Ng T.Y., Ngan H.Y.S. and Wong L.C., Effect of individual psychological intervention in Chinese women with gynecologic malignancy: A randomized controlled trial, Journal of Clinical Oncology. 2005, 23(22): 4913-4924.


Researcher : Yeung WS

List of Research Outputs

Chen E.Y.H., Hui L.M.C., Wong C.K., Dunn E.L.W., Chan W.F., Miao Y.K., Yeung W.S. and Tang O.W.N., Long duration of untreated psychosis is associated with poorer neurocognitive and negative symptom recovery after first episode schizophrenia, Schizophrenia Research. 2006, 81: 231.
Hui L.M.C., Chen E.Y.H., Wong C.K., Dunn E.L.W., Chan W.F., Miao Y.K., Yeung W.S. and Tang O.W.N., The course of semantic memory dysfunction in first-episode schizophrenia, Schizophrenia Research. 2006, 81: 111.


-- End of Listing --