Dept of Pathology

DEPT OF PATHOLOGY

Researcher : Au CWH

List of Research Outputs

Au C.W.H., Siu K.Y., Liao X., Wong E.S.Y., Ngan H.Y.S., Tam K.F., Chan D.C.W., Chan Q.K.Y. and Cheung A.N.Y., Tyrosine kinase B receptor and BDNF expression in ovarian cancers - Effect on cell migration, angiogenesis and clinical outcome, Cancer Letters. 2009, 281: 151-161.

Researcher : Au LK

List of Research Outputs

Au L.K., Wong C.M. and Ng I.O.L., Deregulation of Enhancer of Zeste Homolog 2 (EZH2) in Hepatocellular Carcinoma (HCC), 15th Hong Kong International Cancer Congress. 2008.

Au L.K., Wong C.L., Lee M.F., Wong C.M. and Ng I.O.L., Overexpression of the histone methyltransferase Enhancer of Zeste Homolog 2 was involved in multistep hepatocarcinogenesis and metastasis of hepatocellular carcinoma, American Association for Cancer Research 100th Annual Meeting. Denvoer, CO, USA, 2009.

Researcher : Au WH

List of Research Outputs

Liao X., Siu K.Y., Au W.H., Chan K.Y.Q., Chan H.Y., Wong E.S.Y., Ip P.P.C., Ngan H.Y.S. and Cheung A.N.Y., Aberrant activation of hedgehog signaling pathway contributes to endometrial carcinogenesis through β-catenin., Modern Pathol.. 2009, 22: 839-847.

Liao X., Siu K.Y., Au W.H., Wong E.S.Y., Chan H.Y., Ip P.P.C., Ngan H.Y.S. and Cheung A.N.Y., Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation., Carcinogenesis. 2009, 30: 131-140.

Researcher : Beh SL

List of Research Outputs

Beh S.L., An Overview of Child Homicides in Hong Kong, Xviith International Congress Of The International Society For Prevention Of Child Abuse & Neglect (ispcan). 2008.

Beh S.L., Balancing Global Demands And Local Needs: Effects On Education And Health Human Resources, 1st International Conference on Educational in Health Sciences. 2008.

Beh S.L., Dropping Autopsy Rates: Revisiting The Minimally Invasive Autopsy, 1st International Eurasian Congress Of Forensic Sciences. 2008.

Beh S.L., How Do We Know It Is A Suicide, 3rd Asia Pacific Regional Conference of International Association for Suicide Prevention. 2008.

Beh S.L., International Editorial Board Member, Romanian Journal Of Legal Medicine. Romanian Society of Legal Medicine, 2009.

Beh S.L., Member Of The Forensic Medicine Section Advisory Board, Turkish Clinical Journal Of Medical Sciences. 2009.

Beh S.L., Reducing Autopsy Rates: Revisiting The Minimally Invasive Autopsy, 1st International Eurasian Congress Of Forensic Sciences. 2008.

Beh S.L., Fan K.M., Law W.L. and Patil N.G., Revisiting minimally invasive approach to autopsy , 7th International Symposium On Advances In Legal Medicine (1-5 September 2008). 2008.

Beh S.L., Sustainability of PBL, 6th Asia-pacific Association Of Problem Based Learning In Health Sciences. 2008.

Beh S.L., Sustaining Problem Based Learning - The Hong Kong University Experience, 6th Biennial Conference Of The Asia Pacific Association On Problem-based Learning In Health Sciences. 2008.

Beh S.L., Why Are Autopsy Rates Declining In Hong Kong, 18th Triennial Conference Of The International Association Of Forensic Sciences. New Orleans, 2008.

Yip P.S.F., Wong P.W.C., Cheung Y.T., Chan K...S... and Beh S.L., An empirical study of characteristics and types of homicide-suicides in Hong Kong, 1989-2005, Journal of Affective Disorders. 2009, 112(1-3): 184-192.

Researcher : Cao X

List of Research Outputs

Wu P., Wu J., Liu S., Han X., Lu J., Shi Y., Wang J., Lu L. and Cao X., TLR9/TLR7-triggered downregulation of BDCA2 expression on human plasmacytoid dendritic cells from healthy individuals and lupus patients., In: Wu P, J Wu, S Liu; X Han; J Lu, , Clinical Immunology. 2008, 129(1): 40-8.

Researcher : Castilho AG

List of Research Outputs

Lee K.W., Castilho A.G., Sin S.L., Ma S.K.Y. and Ng I.O.L., The specific targeting of liver cancer stem cells by lupeol through PTEN modulation, American Association for Cancer Research. 2009.

Researcher : Chan ASY

List of Research Outputs

Chan T.L., Yuen S.T., Kuiper R.P., Lee T.Y.H., Tsui W.Y., Lau J.K.Y., Li C., Chan K.W., Kong C.K., Chan A.S.Y., Ligtenberg M.J.L. and Leung S.Y., Deletion of the 3’ Exons of TACSTD1 Causes Hereditary Nonpolyposis Colorectal Cancer with MSH2 Gene Promoter Methylation, The 3rd Biennial Meeting of The International Society for Gastrointestinal Hereditary Tumours (InSiGHT), Dusseldorf, Germany. 2009.

Researcher : Chan AYW

List of Research Outputs

So J.C.C., Song Y., Tsang S.T.Y., Tang L.F., Chan A.Y.W., Ma E.S.K. and Chan L.C., The HBS1L-MYB intergenic region on chromosome 6q23 is a quantitative trait locus controlling fetal haemoglobin level in carries of β-thalassaemia, J Med Gen. 2008, 45(11): 745-51.

Researcher : Chan DW

List of Research Outputs

Chan D.W., Chan P.C.Y., Lee M.F. and Ng I.O.L., Genetic and epigenetic inactivation of T-cadherin in human hepatocellular carcinoma cells, International Journal of Cancer. wiley, 2008, 123: 1043-1052.

Researcher : Chan EYT

List of Research Outputs

Chim J.C.S., Lie A.K.W., Liang R.H.S., Chan E.Y.T. and Kwong Y.L., A total therapy incorporating Bortezomib/thalidomide/dexamethasone in those with insufficient cytoreduction led to a high CR rate, 32nd World Congress of the International Society of Hematology. Thailand, 2008, Abs#323&350.

Lau E.Y.F., So S.Y., Chan E.Y.T., Kwok J.S.Y., Ma J.T.C. and Kung A.W.C., Methimazole-induced antineutrophil cytoplasmic antibody-associated diffuse alveolar haemorrhage in a Chinese woman with Graves' disease, Hong Kong Med J.. 2009, 15(3): 209-12.

Researcher : Chan GSW

List of Research Outputs

Chan G.S.W., Tsoi H.W., Wong S.S.Y., Li C.L., Tse H., Uni K., Yuen K.Y. and Chan K.W., BK virus nephropathy due to KOM-3 strain., American journal of kidney diseases. 2008, 54(1): 122-126.

Hwang Y.Y., Leung A.Y.H., Ng I.O.L., Chan G.S.W., Chan K.W., Tse E.W.C. and Kwong Y.L., Protein-Losing Enteropathy Due to T-Cell Large Granular Lymphocyte Leukemia, Journal of Clinical Oncology. 2009, 27(12): 2097-8.

Lamb S.S., Khong P.L., Chan G.S.W. and Kwong Y.L., DIAGNOSIS IN ONCOLOGY Immunoglobulin M Amyloidosis, Journal of Clinical Oncology. 2009, 27(11): 1915-1916.

Lamb S.S., Khong P.L., Chan G.S.W. and Kwong Y.L., Immunoglobulin M amyloidosis, Journal of Clinical Oncology. 2009, 27: 1915-1916.

Researcher : Chan HY

List of Research Outputs

Chan H.Y., Siu K.Y., Zhang H., Wong E.S.Y., Ngan H.Y.S., Chan K.Y.Q. and Cheung A.N.Y., Activated Stat3 expression in gestational trophoblastic disease: correlation with clinicopathological parameters and apoptotic indices, Histopathology. 2008, 53(2): 139-146.

Kong S.H., Siu K.Y., Chan H.Y., Jiang L., Tam K.F., Ngan H.Y.S., Le X.F. and Cheung A.N.Y., Overexpression of αPIX contributes to ovarian cancer metastasis, increased chemoresistance and poor prognosis., The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18 - 22 April 2009.. 2009.

Liao X., Siu K.Y., Au W.H., Chan K.Y.Q., Chan H.Y., Wong E.S.Y., Ip P.P.C., Ngan H.Y.S. and Cheung A.N.Y., Aberrant activation of hedgehog signaling pathway contributes to endometrial carcinogenesis through β-catenin., Modern Pathol.. 2009, 22: 839-847.

Liao X., Siu K.Y., Au W.H., Wong E.S.Y., Chan H.Y., Ip P.P.C., Ngan H.Y.S. and Cheung A.N.Y., Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation., Carcinogenesis. 2009, 30: 131-140.

Liao X., Chan Y.K., Chan I.L.S., Wong K.Y., Wong E.S.Y., Chan H.Y., Siu K.Y., Khoo U.S., Ngan H.Y.S. and Cheung A.N.Y., Kinesin family member 7 (KIF7) in endometrial and ovarian cancers , The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18 - 22 April 2009. . 2009.

Siu K.Y., Wong E.S.Y., Chan H.Y., Ngan H.Y.S., Chan Y.K. and Cheung A.N.Y., Overexpression of NANOG in Gestational Trophoblastic Diseases. Effect on Apoptosis, Cell Invasion, and Clinical Outcome, Am J Pathol. 2008, [Epub ahead of print].

Zhang H., Siu K.Y., Wong E.S.Y., Chan H.Y., Ngan H.Y.S. and Cheung A.N.Y., Activation of PKB/AKT promotes cell survival and invasion in choriocarcinoma, The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18 - 22 April 2009.. 2009.

Zhao F., Siu K.Y., Wong E.S.Y., Chan H.Y., Jiang L., Ngan H.Y.S. and Cheung A.N.Y., Overexpression of Dock180 in ovarian cancer, The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18 - 22 April 2009.. 2009.

Researcher : Chan ILS

List of Research Outputs

Liao X., Chan Y.K., Chan I.L.S., Wong K.Y., Wong E.S.Y., Chan H.Y., Siu K.Y., Khoo U.S., Ngan H.Y.S. and Cheung A.N.Y., Kinesin family member 7 (KIF7) in endometrial and ovarian cancers , The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18 - 22 April 2009. . 2009.

Researcher : Chan KK

List of Research Outputs

Chan K.K. and Srivastava G., The Anti-Tumor Effect Of An Anti-CD25 mAb On Nasal NK Cell Lymphoma, Abstract of the 12th Research Postgraduate Symposium HKU, LKS Faculty of Medicine. 2008.

Yuen H.F., Kwok W.K., Chan K.K., Chua C.W., Chan Y.P., Chu Y.Y., Wong Y.C., Wang X. and Chan K.W., TWIST modulates prostate cancer cell-mediated bone cell activity and is upregulated by osteogenic induction, Carcinogenesis. 2008, 29(8): 1509-18.

Researcher : Chan KW

List of Research Outputs

Chan G.S.W., Tsoi H.W., Wong S.S.Y., Li C.L., Tse H., Uni K., Yuen K.Y. and Chan K.W., BK virus nephropathy due to KOM-3 strain., American journal of kidney diseases. 2008, 54(1): 122-126.

Chan T.L., Yuen S.T., Kuiper R.P., Lee T.Y.H., Tsui W.Y., Lau J.K.Y., Li C., Chan K.W., Kong C.K., Chan A.S.Y., Ligtenberg M.J.L. and Leung S.Y., Deletion of the 3’ Exons of TACSTD1 Causes Hereditary Nonpolyposis Colorectal Cancer with MSH2 Gene Promoter Methylation, The 3rd Biennial Meeting of The International Society for Gastrointestinal Hereditary Tumours (InSiGHT), Dusseldorf, Germany. 2009.

Dai Y., Qiao L., Chan K.W., Ma J., Zou B., Gu Q., Wang J., Pang R.W.C., Lan H.Y. and Wong B.C.Y., Effect of Embelin on colon carcinogenesis is PPARγ-dependent. 31 May-5 June, 2009, Illinois, Chicago, USA., DDW, 31 May-5 June, 2009, Illinois, Chicago, USA.. 2009.

Dai Y., Qiao L., Chan K.W., Yang M., Ye J., Ma J., Zou B., Gu Q., Wang J., Pang R.W.C., Lan H.Y. and Wong B.C.Y., Peroxisome proliferator-activated receptor-gamma contributes to the inhibitory effects of Embelin on colon carcinogenesis, Cancer Research. 2009, 69 (11): 4776–83.

Hwang Y.Y., Leung A.Y.H., Ng I.O.L., Chan G.S.W., Chan K.W., Tse E.W.C. and Kwong Y.L., Protein-Losing Enteropathy Due to T-Cell Large Granular Lymphocyte Leukemia, Journal of Clinical Oncology. 2009, 27(12): 2097-8.

Lui S.L., Tsang R.C.W., Chan K.W., Zhang Q., Tam S., Yung S.S.Y. and Chan D.T.M., Rapamycin attenuates the severity of murine adriamycin nephropathy [Epub 27Aug 2008], American Journal of Nephropathy. 2008, 29: 342-352.

Ma S.K.Y., Chan K.W., Lee K.W., Tang K.H., Wo Y.H., Zheng B. and Guan X.Y., Aldehyde dehydrogenase discriminates the CD133 liver cancer stem cell populations, Molecular Cancer Research. 2008, 6: 1146-1153.

Ma S.K.Y., Chan Y.P., Woolcock B., Hu L., Wong K.Y., Ling M.T., Bainbridge T., Webber D., Chan H.M., Guan X.Y., Lam W., Vielkind J. and Chan K.W., DNA fingerprinting tags novel altered chromosomal regions and identifies the involvement of SOX5 in the progression of prostate cancer, International Journal of Cancer. 2009, 124: 2323-2332.

Ma S.K.Y., Chan K.W. and Guan X.Y., In search of liver cancer stem cells, Stem Cell Reviews. 2008, 4: 179-192.

Ma S.K.Y., Chan Y.P., Lee K.W., Tang K.H., Ng I.O.L., Man K., To K.F., Zheng B., Chan K.W. and Guan X.Y., The role of miR-130b in the regulation of CD133+ cancer stem cells-driven hepatocellular carcinoma, The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18-22 April 2009.

Tam C.W., Chan K.W., Liu V.W.S., Pang B., Yao K.M. and Shiu S.Y.W., Melatonin as a negative mitogenic hormonal regulator of human prostate epithelial cell growth: potential mechanisms and clinical significance, Journal of Pineal Research. 2008, 45: 403-412.

Tang K.H., Ma S.K.Y., Lee K.W., Ng I.O.L., Man K., To K.F., Zheng B., Guan X.Y. and Chan K.W., CD133+ liver cancer stem cells promote tumor growth and angiogenesis through increased interleukin-8 secretion, The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18-22 April 2009.

Yuen H.F., Chan Y.P., Law S.Y.K., Srivastava G., E1-tanani M., Mak T.W. and Chan K.W., DJ-1 could predict worse prognosis in esophageal squamous cell carcinoma, Cancer Epidemiology, Biomarkers & Prevention. 2008, 17(12): 3593-3602.

Yuen H.F., Kwok W.K., Chan K.K., Chua C.W., Chan Y.P., Chu Y.Y., Wong Y.C., Wang X. and Chan K.W., TWIST modulates prostate cancer cell-mediated bone cell activity and is upregulated by osteogenic induction, Carcinogenesis. 2008, 29(8): 1509-18.

Yung S.S.Y., Zhang Q., Zhang C., Chan K.W., Lui S.L. and Chan D.T.M., Anti-DNA antibody induction of protein kinase C phosphorylation and fibronectin synthesis in human and murine lupus and the effect of mycophenolic acid, Arthritis Rheumatism. 2009, 60: 2071-2082.

Researcher : Chan KW

List of Research Outputs

Chan G.S.W., Tsoi H.W., Wong S.S.Y., Li C.L., Tse H., Uni K., Yuen K.Y. and Chan K.W., BK virus nephropathy due to KOM-3 strain., American journal of kidney diseases. 2008, 54(1): 122-126.

Ma S.K.Y., Chan K.W. and Guan X.Y., In search of liver cancer stem cells, Stem Cell Reviews. 2008, 4: 179-192.

Researcher : Chan KYQ

List of Research Outputs

Chan H.Y., Siu K.Y., Zhang H., Wong E.S.Y., Ngan H.Y.S., Chan K.Y.Q. and Cheung A.N.Y., Activated Stat3 expression in gestational trophoblastic disease: correlation with clinicopathological parameters and apoptotic indices, Histopathology. 2008, 53(2): 139-146.

Chan K.Y.Q., Ngan H.Y.S., Ip P.P.C., Liu V.W.S., Xue W. and Cheung A.N.Y., Tumor suppressor effect of follistatin-like 1 in ovarian and endometrial carcinogenesis: a differential expression and functional analysis, Carcinogenesis. Oxford Journals, 2009, 30: 114-121.

Liao X., Siu K.Y., Au W.H., Chan K.Y.Q., Chan H.Y., Wong E.S.Y., Ip P.P.C., Ngan H.Y.S. and Cheung A.N.Y., Aberrant activation of hedgehog signaling pathway contributes to endometrial carcinogenesis through β-catenin., Modern Pathol.. 2009, 22: 839-847.

Liao X., Siu K.Y., Wong E.S.Y., Ngan H.Y.S., Chan K.Y.Q., Li A.S.M., Khoo U.S. and Cheung A.N.Y., Hypermethylation of RAS effector related genes and DNA methyltransferase 1 expression in endometrial carcinogenesis, Int J Cancer. 2008, 123(2): 296-302.

Researcher : Chan LC

List of Research Outputs

Chan L.C., American Journal of Haematology. 2008.

Chan L.C., Factors affecting quality of PBL in medical curriculum, Kaohsiung Medical University International Conference and Workshop on PBL, Taiwan, July 2008. 2008.

Chan L.C., Factors affecting the quality of problem-based learning in a hybrid medical curriculum, The Kaohsiung Journal of Medical Sciences. 2009, 32(5): 254-257.

Chan L.C., Medical Humanities : Conversations, Framing Histories in Medicine presented by the Humanities, Science and Medicine Forum, The University of Hong Kong. December 2008. 2008.

Chan L.C., Plenary Session on "Humanities in Undergraduate Medical Education – Why it Matters to Doctors and Patients?" Topic: "Medical Humanities – the gift of understanding suffering and the development of compassion" , Frontiers in Medical and Health Sciences Education – Making Doctors Human. LKS Faculty of Medicine, The University of Hong Kong, December 2008. 2008.

Chan L.C., Quality Affecting Problem Based Learning, Medical Education Meeting, Kaohsiung Medical University, Taiwan, January 2009. 2009.

Chan L.C., Teaching and Learning of Pathology in the Medical Curriculum, Teaching Workshop in Kaohsiung Medical University organized by Kaohsiung Medical College Post Baccalaureate English Program, Taiwan, March 2009. 2009.

Chen J.Y., Chan L.K. and Chan L.C., Medical humanities in the undergraduate medical curriculum: can it happen in Hong Kong? , 2009 Asia-Pacific Regional Conference of World Organization of National Colleges, Academies and Academic Associations of General Practitioners/Family Physicians (WONCA). 2009.

Sedgewick A.E., Timofeev N., Sebastiani P., So J.C.C., Ma E.S.K., Chan L.C., Fucharoen G., Fucharoen S., Barbosa C.G., Vardarajan B.N., Farrer L.A., Baldwin C.T., Steinberg M.H. and Chui D.H.K., BCL11A is a major HbF quantitative trait locus in three different populations with beta-hemoglobinopathies, Blood Cells Mol Dis. 2008, 41(3): 255-8.

So J.C.C., Wan T.S.K., Ma E.S.K. and Chan L.C., An unbalanced translocation, der(17)t(1;17)(p13;p11.2), leads to heterozygous loss of TP53 and is associated with clinical evolution in myelodysplastic syndrome, Br J Biomed Sci. 2008, 65(1): 36-38.

So J.C.C., Leung R.Y.Y., Yip S.F., Lam C.C.K. and Chan L.C., Invasive Streptococcus pneumoniae infection associated with hemolytic uremic syndrome in Chinese pediatric patients. , 50th American Society of Hematology Annual Meeting and Expositions, USA. 2008.

So J.C.C., Song Y., Tsang S.T.Y., Tang L.F., Chan A.Y.W., Ma E.S.K. and Chan L.C., The HBS1L-MYB intergenic region on chromosome 6q23 is a quantitative trait locus controlling fetal haemoglobin level in carries of β-thalassaemia, J Med Gen. 2008, 45(11): 745-51.

Sun Q., So J.C.C., Yip S.F., Wan T.S.K., Ma E.S.K. and Chan L.C., Functional alterations of Lin-CD34+CD38+ cells in chronic myelomonocytic leukemia and on progression to acute leukemia, Leuk Res. 2008, 32(9): 1374-1381.

Researcher : Chan LK

List of Research Outputs

Chan L.K., Ko F.C.F., Ng I.O.L. and Yam J.W.P., Deleted in liver cancer 1 (DLC1) utilizes a novel binding site for Tensin2 PTB domain interaction and is required for tumor-suppressive function, PLoS One. 2009, 4: e5572.

Ko F.C.F., Chan L.K., Ng I.O.L. and Yam J.W.P., Post-translational modification of Deleted in Liver Cancer 1 (DLC1) tumor suppressor, The 6th International Meeting Hepatocellular Carcinoma: Eastern and Western Experiences, Seoul, Korea. 2008.

Wong C.C.L., Wong C.M., Ko F.C.F., Chan L.K., Ching Y.P., Yam J.W.P. and Ng I.O.L., Deleted in liver cancer 1 (DLC1) negatively regulates Rho/ROCK/MLC pathway in hepatocellular carcinoma, PLoS One. 2008, 3: e2779.

Yam J.W.P., Ko F.C.F., Chan L.K. and Ng I.O.L., Functional implications of Akt phosphorylation of Deleted in Liver Cancer 1 (DLC1), American Association for Cancer Research 100th Annual Meeting, Denver, Colorado, USA. 2009.

Researcher : Chan PCY

List of Research Outputs

Chan D.W., Chan P.C.Y., Lee M.F. and Ng I.O.L., Genetic and epigenetic inactivation of T-cadherin in human hepatocellular carcinoma cells, International Journal of Cancer. wiley, 2008, 123: 1043-1052.

Researcher : Chan QKY

List of Research Outputs

Au C.W.H., Siu K.Y., Liao X., Wong E.S.Y., Ngan H.Y.S., Tam K.F., Chan D.C.W., Chan Q.K.Y. and Cheung A.N.Y., Tyrosine kinase B receptor and BDNF expression in ovarian cancers - Effect on cell migration, angiogenesis and clinical outcome, Cancer Letters. 2009, 281: 151-161.

Researcher : Chan SY

List of Research Outputs

Chan Y.K., Liu W., Long J.R., Yip S.P., Chan S.Y., Shu X.O., Chua D.T.T., Cheung A.N.Y., Ching C.Y.J., Cai H., Au G.K.H., Chan M., Foo W., Ngan H.Y.S., Gao Y.T., Ngan E.S.W., Garcia-Barcelo M.M., Zheng W. and Khoo U.S., Functional polymorphisms in the BRCA1 promoter influence transcription and are associated with decreased risk for breast cancer in Chinese women., J Med Genet. 2009, 46: 32-39.

Researcher : Chan TL

List of Research Outputs

Chan T.L., Yuen S.T., Kuiper R.P., Lee T.Y.H., Tsui W.Y., Lau J.K.Y., Li C., Chan K.W., Kong C.K., Chan A.S.Y., Ligtenberg M.J.L. and Leung S.Y., Deletion of the 3’ Exons of TACSTD1 Causes Hereditary Nonpolyposis Colorectal Cancer with MSH2 Gene Promoter Methylation, The 3rd Biennial Meeting of The International Society for Gastrointestinal Hereditary Tumours (InSiGHT), Dusseldorf, Germany. 2009.

Chan T.L., Outstanding Young Researcher Awards, The University of Hong Kong. 2008.

Chan T.L., The Role of Genetic and Epigenetic Interaction in Hereditary Colorectal Cancer, German Cancer Research Center, Germany. 2009.

Ligtenberg M.J., Kuiper R.P., Chan T.L., Goossens M., Hebeda K.M., Voorendt M., Lee T.Y.H., Bodmer D., Hoenselaar E., Hendriks-Cornelissen S.J., Tsui W.Y., Kong C.K., Brunner H.G., van Kessel A.G., Yuen S.T., van Krieken J.H., Leung S.Y. and Hoogerbrugge N., Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3' exons of TACSTD1, Nat Genet. 2009, 41(1): 112-7.

Schetter A.J., Leung S.Y., Sohn J.J., Zanetti K.A., Bowman E.D., Yanaihara N., Yuen S.T., Chan T.L., Kwong D.L.W., Au G.K., Liu C.G., Calin G.A., Croce C.M. and Harris C.C., MicroRNA Expression Profiles Associated With Prognosis And Therapeutic Outcome In Colon Adenocarcinoma., Journal of the American Medical Association. 2008, 299: 425-36.

Researcher : Chan WY

List of Research Outputs

Li O.T.W., Chan M.C.W., Leung C.S.W., Chan W.Y., Guan Y., Nicholls J.M. and Poon L.L.M., Full factorial analysis of Mammalian and avian influenza polymerase subunits suggests a role of an efficient polymerase for virus adaptation., In: Li OT, Chan MC, Leung CS, Chan RW, Guan Y, Nicholls JM, Poon LL., PLoS ONE. 2009, 21;4(5): e5658.

Nicholls J.M., Chan M.C.W., Chan W.Y., Cheung C.Y., Kwong D.L.W., Wong M.P., Poon L.L.M., Tsao G.S.W. and Guan Y., 2008 Research Output Prize/Faculty Outstanding Research Output Award, The University of Hong Kong. 2008.

Nicholls J.M., Chan M.C.W., Chan W.Y., Peiris J.S.M., Malakhov M., Li H., Huang Y., Zaltash S., Hawley S., Haslam S., Karamanska R. and Fang F., The use of sialidase treatment in influenza virus infection , XI International Symposium on Respiratory Viral Infections. 2009.

Researcher : Chan YK

List of Research Outputs

Chan Y.K., Liu W., Long J.R., Yip S.P., Chan S.Y., Shu X.O., Chua D.T.T., Cheung A.N.Y., Ching C.Y.J., Cai H., Au G.K.H., Chan M., Foo W., Ngan H.Y.S., Gao Y.T., Ngan E.S.W., Garcia-Barcelo M.M., Zheng W. and Khoo U.S., Functional polymorphisms in the BRCA1 promoter influence transcription and are associated with decreased risk for breast cancer in Chinese women., J Med Genet. 2009, 46: 32-39.

Chan Y.K., Liu W., Long J.R., Yip S.P., Chan S.Y., Shu X.O., Chua D.T.T., Cheung A.N.Y., Ching J.C.Y., Cai H., Au G.K.H., Chan M., Foo W., Ngan H.Y.S., Gao Y.T., Ngan E.S.W., Garcia-Barcelo M.M., Zheng W.E.I. and Khoo U.S., Functional polymorphisms in the promoter of BRCA1 influences transcription and are associated with decreased risk for breast cancer in Chinese women, Journal of Medical Genetics. 2009, 46(1): 32-39.

Chen J., Wu L.H., Ip Y.C., Chan Y.K., Lam E.W. and Khoo U.S., Study of FOXO3a and the development of tamoxifen resistance in breast cancer , The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18 - 22 April 2009. . 2009.

Ip Y.C., Chan Y.K., Wong S.Y., Cheung S.T. and Khoo U.S., Targeting granulin-epithelin precursor in breast cancer , The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18 - 22 April 2009. . 2009.

Liao X., Chan Y.K., Chan I.L.S., Wong K.Y., Wong E.S.Y., Chan H.Y., Siu K.Y., Khoo U.S., Ngan H.Y.S. and Cheung A.N.Y., Kinesin family member 7 (KIF7) in endometrial and ovarian cancers , The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18 - 22 April 2009. . 2009.

Siu K.Y., Wong E.S.Y., Chan H.Y., Ngan H.Y.S., Chan Y.K. and Cheung A.N.Y., Overexpression of NANOG in Gestational Trophoblastic Diseases. Effect on Apoptosis, Cell Invasion, and Clinical Outcome, Am J Pathol. 2008, [Epub ahead of print].

Ting K.P., Wu L.H., Ip Y.C., Khoo U.S. and Chan Y.K., Mini-chromosome-maintenance-deficient 4 (MCM4) in breast cancer and its clinical significance (Oral presentation), The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18 - 22 April 2009. . 2009.

Researcher : Chan YP

List of Research Outputs

Ma S.K.Y., Chan Y.P., Woolcock B., Hu L., Wong K.Y., Ling M.T., Bainbridge T., Webber D., Chan H.M., Guan X.Y., Lam W., Vielkind J. and Chan K.W., DNA fingerprinting tags novel altered chromosomal regions and identifies the involvement of SOX5 in the progression of prostate cancer, International Journal of Cancer. 2009, 124: 2323-2332.

Ma S.K.Y., Chan Y.P., Lee K.W., Tang K.H., Ng I.O.L., Man K., To K.F., Zheng B., Chan K.W. and Guan X.Y., The role of miR-130b in the regulation of CD133+ cancer stem cells-driven hepatocellular carcinoma, The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18-22 April 2009.

Yuen H.F., Chan Y.P., Law S.Y.K., Srivastava G., E1-tanani M., Mak T.W. and Chan K.W., DJ-1 could predict worse prognosis in esophageal squamous cell carcinoma, Cancer Epidemiology, Biomarkers & Prevention. 2008, 17(12): 3593-3602.

Yuen H.F., Kwok W.K., Chan K.K., Chua C.W., Chan Y.P., Chu Y.Y., Wong Y.C., Wang X. and Chan K.W., TWIST modulates prostate cancer cell-mediated bone cell activity and is upregulated by osteogenic induction, Carcinogenesis. 2008, 29(8): 1509-18.

Researcher : Chen J

List of Research Outputs

Chen J., Wu L.H., Ip Y.C., Chan Y.K., Lam E.W. and Khoo U.S., Study of FOXO3a and the development of tamoxifen resistance in breast cancer , The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18 - 22 April 2009. . 2009.

Researcher : Chen WYW

List of Research Outputs

Dong G., Chanudet E., Hamoudi R.A., Chen W.Y.W., Chuang S.S., Ye H., Liu H., Gao Z., Srivastava G. and Du M.Q., Genomic Profiles of Gastrointestinal Diffuse Large B-cell Lymphoma, The Journal of Pathology. 2009, 219: S5.

Researcher : Cheung ANY

List of Research Outputs

Au C.W.H., Siu K.Y., Liao X., Wong E.S.Y., Ngan H.Y.S., Tam K.F., Chan D.C.W., Chan Q.K.Y. and Cheung A.N.Y., Tyrosine kinase B receptor and BDNF expression in ovarian cancers - Effect on cell migration, angiogenesis and clinical outcome, Cancer Letters. 2009, 281: 151-161.

Chan D.W., Yu Y.M., Chiu P.M., Yao K.M., Liu V.W.S., Cheung A.N.Y. and Ngan H.Y.S., Over-expression of FOXM1 transcription factor is associated with cervical cancer progression and pathogenesis, Journal of Pathology. 2008, 215 (3): 245-252.

Chan H.Y., Siu K.Y., Zhang H., Wong E.S.Y., Ngan H.Y.S., Chan K.Y.Q. and Cheung A.N.Y., Activated Stat3 expression in gestational trophoblastic disease: correlation with clinicopathological parameters and apoptotic indices, Histopathology. 2008, 53(2): 139-146.

Chan K.Y.Q., Ngan H.Y.S., Ip P.P.C., Liu V.W.S., Xue W. and Cheung A.N.Y., Tumor suppressor effect of follistatin-like 1 in ovarian and endometrial carcinogenesis: a differential expression and functional analysis, Carcinogenesis. Oxford Journals, 2009, 30: 114-121.

Chan Y.K., Liu W., Long J.R., Yip S.P., Chan S.Y., Shu X.O., Chua D.T.T., Cheung A.N.Y., Ching C.Y.J., Cai H., Au G.K.H., Chan M., Foo W., Ngan H.Y.S., Gao Y.T., Ngan E.S.W., Garcia-Barcelo M.M., Zheng W. and Khoo U.S., Functional polymorphisms in the BRCA1 promoter influence transcription and are associated with decreased risk for breast cancer in Chinese women., J Med Genet. 2009, 46: 32-39.

Chan Y.K., Liu W., Long J.R., Yip S.P., Chan S.Y., Shu X.O., Chua D.T.T., Cheung A.N.Y., Ching J.C.Y., Cai H., Au G.K.H., Chan M., Foo W., Ngan H.Y.S., Gao Y.T., Ngan E.S.W., Garcia-Barcelo M.M., Zheng W.E.I. and Khoo U.S., Functional polymorphisms in the promoter of BRCA1 influences transcription and are associated with decreased risk for breast cancer in Chinese women, Journal of Medical Genetics. 2009, 46(1): 32-39.

Cheung A.N.Y., Guan X.Y. and Ngan H.Y.S., Application of novel markers to cervical cytology for enhancing cervical cancer screening, Health Research Symposium 2007: Building bridges between research, practice & policy, Hong Kong, 30 Sep - 1 Oct. 2008.

Cheung A.N.Y., Gestational Trophoblastic Disease, In: Robboy S, Mutter G, Prat J, Bentley RC, Russell P, Anderson MC, Robboy's Pathology of the Female Reproductive Tract. Elsevier Science Health Science Div, 2009, 881-907.

Cheung A.N.Y., Gynecological malignancies in genetically susceptible women, Satellite Symposium for Gynecologic Pathology in the International Gynecologic Cancer Society 12th Biennial Meeting, Bangkok, 25 October. 2008.

Cheung A.N.Y., Gynecological malignancies in genetically susceptible women, in The 2008 China International Congress of Gynecological Oncology, Beijing, 31 October. 2008.

Cheung A.N.Y., HPV Molecular Test in Prevention of Cervical Cancer - Recent Advances, in the 9th Chinese Laboratory Medicine Conference, Hong Kong, 26-29 June. 2009.

Cheung A.N.Y., Hong Kong West Cluster and Queen Mary Hospital Outstanding Teams Award 2009 for “Gynae-Oncology Team, QMH”, Hospital Authority, Hong Kong. 2009.

Cheung A.N.Y., Journal Editor, The International Journal of Obstetrics & Gynecology, China. 2009.

Cheung A.N.Y., Zhang H., Xue W. and Siu K.Y., Pathogenesis of choriocarcinoma: clinical, genetic and stem cell perspectives, Future Oncology. 2009, 5(2): 217-231.

Cheung A.N.Y., Recent Advances on Cervical Cytology – New Techniques, new systems and New Markers, in the 8th Annual Meeting of Chinese Society of Cytopathology, GuangZhou, 28 March. 2009.

Cheung A.N.Y., Updates on Cervical Cytology for the Detection of Cancer, in the Co-joint Seminars organized by the Hong Kong Society of Cytology with Chinese American Pathologist Association, Hong Kong, 21 March. 2009.

Chow C.P., Ho M.H.K., Chan G.C.F., Cheung A.N.Y. and Ha S.Y., Congenital Rosai-Dorfman disease presenting with anemia, thrombocytopenia, and hepatomegaly, Pediatric Blood & Cancer. 2009, 52(3): 415-417.

Deng W., Tsao G.S.W., Kwok K.Y., Wong E.S.Y., Huang X.R., Liu S., Tsang C.M., Ngan H.Y.S., Cheung A.N.Y., Lan H.Y., Guan X.Y. and Cheung A., Transforming growth factor b1 promotes chromosomal instability in human papillomavirus 16 E6E7-infected cervical epithelial cells, Cancer Research. 2008, 68: 7200-7209.

Kong S.H., Siu K.Y., Chan H.Y., Jiang L., Tam K.F., Ngan H.Y.S., Le X.F. and Cheung A.N.Y., Overexpression of αPIX contributes to ovarian cancer metastasis, increased chemoresistance and poor prognosis., The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18 - 22 April 2009.. 2009.

Kwan T.T.C., Chan K.K.L., Yip M.W., Tam K.F., Cheung A.N.Y., Lo S.S.T., Lee P.W.H. and Ngan H.Y.S., Acceptability of human papillomavirus vaccination among Chinese women: concerns and implications, BJOG An International Journal of Obstetrics and Gynaecology. 2009, 116 (4): 501-510.

Lee C.K.F., Tam Y.T., Zuo Y., Cheong A.W.Y., Pang R.T.K., Lee P.Y., Shum K.Y., Tam P.C., Cheung A.N.Y., Yang Z.M., Yeung W.S.B. and Luk J.M.C., Characterization of an acrosome protein VAD1.2/AEP2 which is differentially expressed in spermatogenesis, Molecular Human Reproduction. 2008, 14(8): 465-474.

Leung G.M., Woo P.S., Cowling B.J., Tsang C.S.H., Cheung A.N.Y., Ngan H.Y.S., Galbraith K.P. and Lam T.H., Who receives, benefits from and is harmed by cervical and breast cancer screening among Hong Kong Chinese?, Journal of Public Health. 2008, 30(3): 282-292.

Li A.S., Siu M.K., Zhang H., Wong E.S., Chan K.Y., Ngan H.Y.S. and Cheung A.N.Y., Hypermethylation of SOX2 gene in hydatidiform mole and choriocarcinoma, Reproductive Science. PubMed PMID:18836133, 2008, 15(7): 735-744.

Liao X., Siu M.K., Au C.W.D., Chan Q.K., Chan H.Y., Wong E.S., IP P.P., Ngan H.Y.S. and Cheung A.N.Y., Aberrant activation of hedgehog signaling pathway contributes to endometrial carcinogenesis through beta-catenin, Mod Pathol. 2009 Jun;22(6):839-47. Epub 2009 Mar 27. 2009, 839-47.

Liao X., Siu K.Y., Au W.H., Chan K.Y.Q., Chan H.Y., Wong E.S.Y., Ip P.P.C., Ngan H.Y.S. and Cheung A.N.Y., Aberrant activation of hedgehog signaling pathway contributes to endometrial carcinogenesis through β-catenin., Modern Pathol.. 2009, 22: 839-847.

Liao X., Siu K.Y., Au W.H., Wong E.S.Y., Chan H.Y., Ip P.P.C., Ngan H.Y.S. and Cheung A.N.Y., Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation., Carcinogenesis. 2009, 30: 131-140.

Liao X., Siu K.Y., Wong E.S.Y., Ngan H.Y.S., Chan K.Y.Q., Li A.S.M., Khoo U.S. and Cheung A.N.Y., Hypermethylation of RAS effector related genes and DNA methyltransferase 1 expression in endometrial carcinogenesis, Int J Cancer. 2008, 123(2): 296-302.

Liao X., Chan Y.K., Chan I.L.S., Wong K.Y., Wong E.S.Y., Chan H.Y., Siu K.Y., Khoo U.S., Ngan H.Y.S. and Cheung A.N.Y., Kinesin family member 7 (KIF7) in endometrial and ovarian cancers , The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18 - 22 April 2009. . 2009.

Liu S., Leung C.Y., Cheung A.N.Y., Xie L., Zhang X. and Ngan H.Y.S., Evaluation of a Newly Developed GenoArray HPV Genotyping Assay, 25th International Papillomavirus Conference, P26.059, Malmo, Sweden, May 8-14. 2009.

Ngan H.Y.S., Cheung A.N.Y., Tam K.F., Chan K.K.L., Tang H., Bi D., Descamps D. and Bock H.L., Immunogenicity and safety of cervarizTM in healthy women in Hong Kong , 12th Biennial Meeting, International Gynecologic Cancer Society, October 25-28, 2008 in Bangkok, Thailand. 2008.

Pon Y.L., Zhou G., Cheung A.N.Y., Ngan H.Y.S. and Wong A.S.T., p70 S6 kinase promotes epithelial to mesenchymal transition through snail induction in ovarian cancer cells., Cancer Research. PubMed PMID:18701475, 2008, 68(16): 6524-6532.

Siu K.Y., Wong E.S.Y., Chan H.Y., Ngan H.Y.S., Chan Y.K. and Cheung A.N.Y., Overexpression of NANOG in Gestational Trophoblastic Diseases. Effect on Apoptosis, Cell Invasion, and Clinical Outcome, Am J Pathol. 2008, [Epub ahead of print].

Tay S.K., Ngan H.Y.S., Chu T.Y., Cheung A.N.Y. and Tay E.H., Epidemiology of human papillomavirus infection and cervical cancer and future perspectives in Hong Kong, Singapore and Taiwan, Vaccine. PubMed PMID:18945415, 2008, 19 (Suppl 12): M60-70.

Tse K.Y., Liu V.W.S., Chan D.W., Chiu P.M., Tam K.F., Chan K.K.L., Liao X., Cheung A.N.Y. and Ngan H.Y.S., Epigenetic alteration of the metallothionein 1E gene in human endometrial carcinomas, Tumor Biology. 2009, 30: 93-99.

Zhang H., Siu K.Y., Wong E.S.Y., Chan H.Y., Ngan H.Y.S. and Cheung A.N.Y., Activation of PKB/AKT promotes cell survival and invasion in choriocarcinoma, The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18 - 22 April 2009.. 2009.

Zhang H., Xue W.C., Siu K.Y., Liao X., Ngan H.Y.S. and Cheung A.N.Y., P63 Expression in Gestational Trophoblastic Disease: Correlation With Proliferation and Apoptotic Dynamics., Int. J. Gynecol. Pathol. . 2009, 28: 172-178.

Zhao F., Siu K.Y., Wong E.S.Y., Chan H.Y., Jiang L., Ngan H.Y.S. and Cheung A.N.Y., Overexpression of Dock180 in ovarian cancer, The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18 - 22 April 2009.. 2009.

Researcher : Cheung OF

List of Research Outputs

Yau T.O., Chan C.F., Lam S.G.S., Cheung O.F., Ching Y.P., Jin D., Sham M.H. and Ng I.O.L., Hepatocyte-specific activation of NF-KB does not aggravate chemical hepatocarcinogenesis in transgenic mice, The Journal of Pathology. 2008, 217: 353-361.

Researcher : Ching CYJ

List of Research Outputs

Chan Y.K., Liu W., Long J.R., Yip S.P., Chan S.Y., Shu X.O., Chua D.T.T., Cheung A.N.Y., Ching C.Y.J., Cai H., Au G.K.H., Chan M., Foo W., Ngan H.Y.S., Gao Y.T., Ngan E.S.W., Garcia-Barcelo M.M., Zheng W. and Khoo U.S., Functional polymorphisms in the BRCA1 promoter influence transcription and are associated with decreased risk for breast cancer in Chinese women., J Med Genet. 2009, 46: 32-39.

Researcher : Ching JCY

List of Research Outputs

Chan Y.K., Liu W., Long J.R., Yip S.P., Chan S.Y., Shu X.O., Chua D.T.T., Cheung A.N.Y., Ching J.C.Y., Cai H., Au G.K.H., Chan M., Foo W., Ngan H.Y.S., Gao Y.T., Ngan E.S.W., Garcia-Barcelo M.M., Zheng W.E.I. and Khoo U.S., Functional polymorphisms in the promoter of BRCA1 influences transcription and are associated with decreased risk for breast cancer in Chinese women, Journal of Medical Genetics. 2009, 46(1): 32-39.

Researcher : Ching YP

List of Research Outputs

Wong C.C.L., Wong C.M., Ko F.C.F., Chan L.K., Ching Y.P., Yam J.W.P. and Ng I.O.L., Deleted in liver cancer 1 (DLC1) negatively regulates Rho/ROCK/MLC pathway in hepatocellular carcinoma, PLoS One. 2008, 3: e2779.

Researcher : Chiu PM

List of Research Outputs

Chan D.W., Yu Y.M., Chiu P.M., Yao K.M., Liu V.W.S., Cheung A.N.Y. and Ngan H.Y.S., Over-expression of FOXM1 transcription factor is associated with cervical cancer progression and pathogenesis, Journal of Pathology. 2008, 215 (3): 245-252.

Researcher : Choi WL

List of Research Outputs

Choi W.L., Molecular Classification Of Diffuse Large B-cell Lymphoma: Implications And Impact , Hong Kong Society of Haematology June Meeting. 2009.

Fu K., Weisenburger D.D., Choi W.L., Perry K.D., Smith L.M., Shi X., Hans C.P., Greiner T.C., Bierman P.J., Bociek R.G., Armitage J.O., Chan W.C. and Vose J.M., Addition Of Rituximab To Standard Chemotherapy Improves The Survival Of Both The Germinal Center B-cell-like And Non-germinal Center B-cell-like Subtypes Of Diffuse Large B-cell Lymphoma, Journal Of Clinical Oncology . 2008, 26: 4587-4594.

Gu K., Fu K., Chan W.C., Greiner T.C., Aoun P., Smith L.M., Liu Z., Meyer P.N., Choi W.L., Bociek G., Vose J.M. and Weisenburger D.D., Neither Cell Of Origin Algorithms Or LMO2 Expression Predicts Survival In DLBCL Treated With Autologous Hematopoietic Stem Cell (HSC) Transplantation, United States and Canadian Academy of Pathology 98th Annual Meeting. 2009.

Meyer P.N., Weisenburger D.D., Choi W.L., Smith L.M., Greiner T.C., Aoun P., Delabie J., Braziel R.M., Vose J.M., Lenz G., Staudt L.M., Chan W.C. and Fu K., LMO2 Expression And The Hans Algorithm In Predicting Germinal Center Phenotype And Survival In Diffuse Large B-cell Lymphoma Treated With Rituximab , United States and Canadian Academy of Pathology 98th Annual Meeting. 2009.

Naushad H., Choi W.L., Page C.J., Sanger W.G., Weisenburger D.D. and Aoun P., Mantle Cell Lymphoma with Flow Cytometric Evidence of Clonal Plasmacytic Differentiation: A Case Report, Cytometry: Part B -- Clinical Cytometry. Wiley-Blackwell, 2009, 76: 218-224.

Researcher : Chung LP

List of Research Outputs

Leung L.H., Tam I.Y., Tin P.C., Chua D.T.T., Sihoe A.D.L., Cheung L.C., Ho J.C.M., Chung L.P. and Wong M.P., Src Promotes Survival and Invasion of Lung Cancers with Epidermal Growth Factor Receptor Abnormalities and Is a Potential Candidate for Molecular-Targeted Therapy., Molecular Cancer Research. 2009, 7(6): 923-32.

So K.T., Tam I.Y., Leung L.H., Tin P.C., Wong W.S., Sihoe A.D.L., Cheng L.C., Chung L.P. and Wong M.P., Mutational analysis of EGFR-related genes in non-small cell lung cancer (Poster), American Association for Cancer Research Annual Meeting, 2009 April 18-22, 2009, Denver, Colorado, the United State . 2009.

Tam I.Y., Leung L.H., Tin P.C., Chua D.T.T., Sihoe A.D.L., Cheng L.C., Chung L.P. and Wong M.P., EGFR mutants containing rare EGFR mutant types show reduced response to in-vitro gefitinib compared to common activating missense mutations (Poster), American Association for Cancer Research Annual Meeting, 2009 April 18-22, 2009, Denver, Colorado, the United State . 2009.

Wong W.S., Leung L.H., Tin P.C., Sihoe A.D.L., Cheng L.C., Chung L.P. and Wong M.P., ALK kinase domain is aberrantly expressed but not mutated in Chinese non-small cell lung cancer from male smokers with squamous cell carcinoma (Poster), American Association for Cancer Research Annual Meeting, 2009 April 18-22, 2009, Denver, Colorado, the United State . 2009.

Wong W.S., Leung L.H., So K.T., Tam Y.S.I., Sihoe A.D.L., Cheng L.C., Ho K.K., Au J.S., Chung L.P. and Wong M.P., The Eml4-alk Fusion Gene Is Involved In Various Histologic Types Of Lung Cancers From Nonsmokers With Wild-type Egfr And Kras, Cancer. 2009, 115: 1723-1733.

Researcher : Fan PYS

List of Research Outputs

Fan P.Y.S., Lui P.C., Tam K.Y., Hung K.N., Ng H.K. and Leung S.Y., A 33-year-old Chinese woman with a left frontal tumor, Brain Pathol.. 2009, 19(2): 337-40.

Researcher : Ip PPC

List of Research Outputs

Chan K.Y.Q., Ngan H.Y.S., Ip P.P.C., Liu V.W.S., Xue W. and Cheung A.N.Y., Tumor suppressor effect of follistatin-like 1 in ovarian and endometrial carcinogenesis: a differential expression and functional analysis, Carcinogenesis. Oxford Journals, 2009, 30: 114-121.

Liao X., Siu K.Y., Au W.H., Chan K.Y.Q., Chan H.Y., Wong E.S.Y., Ip P.P.C., Ngan H.Y.S. and Cheung A.N.Y., Aberrant activation of hedgehog signaling pathway contributes to endometrial carcinogenesis through β-catenin., Modern Pathol.. 2009, 22: 839-847.

Liao X., Siu K.Y., Au W.H., Wong E.S.Y., Chan H.Y., Ip P.P.C., Ngan H.Y.S. and Cheung A.N.Y., Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation., Carcinogenesis. 2009, 30: 131-140.

Yuen R.M.F., Wong D.K.H., Fung J.Y.Y., Ip P.P.C., But D., Hung I.F.N., Lau K., Yuen J.C.H. and Lai C.L., HBsAg Seroclearance in Chronic Hepatitis B in Asian Patients: Replicative Level and Risk of Hepatocellular Carcinoma, Gastroenterology. 2008, 135(4): 1192-9.

Researcher : Ip YC

List of Research Outputs

Chen J., Wu L.H., Ip Y.C., Chan Y.K., Lam E.W. and Khoo U.S., Study of FOXO3a and the development of tamoxifen resistance in breast cancer , The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18 - 22 April 2009. . 2009.

Ip Y.C., Chan Y.K., Wong S.Y., Cheung S.T. and Khoo U.S., Targeting granulin-epithelin precursor in breast cancer , The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18 - 22 April 2009. . 2009.

Ting K.P., Wu L.H., Ip Y.C., Khoo U.S. and Chan Y.K., Mini-chromosome-maintenance-deficient 4 (MCM4) in breast cancer and its clinical significance (Oral presentation), The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18 - 22 April 2009. . 2009.

Researcher : Jiang L

List of Research Outputs

Kong S.H., Siu K.Y., Chan H.Y., Jiang L., Tam K.F., Ngan H.Y.S., Le X.F. and Cheung A.N.Y., Overexpression of αPIX contributes to ovarian cancer metastasis, increased chemoresistance and poor prognosis., The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18 - 22 April 2009.. 2009.

Zhao F., Siu K.Y., Wong E.S.Y., Chan H.Y., Jiang L., Ngan H.Y.S. and Cheung A.N.Y., Overexpression of Dock180 in ovarian cancer, The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18 - 22 April 2009.. 2009.

Researcher : Khoo US

List of Research Outputs

Chan V.N.Y., Khoo U.S., Wong M.S., Lau K.M.K., Suen D.T.K., Li G.K.H., Kwong A. and Chan T.K., Localization of hRad9 in breast cancer, BMC Cancer. 2008, 8: 196.

Chan Y.K., Liu W., Long J.R., Yip S.P., Chan S.Y., Shu X.O., Chua D.T.T., Cheung A.N.Y., Ching C.Y.J., Cai H., Au G.K.H., Chan M., Foo W., Ngan H.Y.S., Gao Y.T., Ngan E.S.W., Garcia-Barcelo M.M., Zheng W. and Khoo U.S., Functional polymorphisms in the BRCA1 promoter influence transcription and are associated with decreased risk for breast cancer in Chinese women., J Med Genet. 2009, 46: 32-39.

Chan Y.K., Liu W., Long J.R., Yip S.P., Chan S.Y., Shu X.O., Chua D.T.T., Cheung A.N.Y., Ching J.C.Y., Cai H., Au G.K.H., Chan M., Foo W., Ngan H.Y.S., Gao Y.T., Ngan E.S.W., Garcia-Barcelo M.M., Zheng W.E.I. and Khoo U.S., Functional polymorphisms in the promoter of BRCA1 influences transcription and are associated with decreased risk for breast cancer in Chinese women, Journal of Medical Genetics. 2009, 46(1): 32-39.

Chen J., Wu L.H., Ip Y.C., Chan Y.K., Lam E.W. and Khoo U.S., Study of FOXO3a and the development of tamoxifen resistance in breast cancer , The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18 - 22 April 2009. . 2009.

Ip Y.C., Chan Y.K., Wong S.Y., Cheung S.T. and Khoo U.S., Targeting granulin-epithelin precursor in breast cancer , The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18 - 22 April 2009. . 2009.

Khoo U.S., Molecular Genetic Testing of Breast and Ovarian Cancer, 9th Chinese Laboratory Medicine Conference, Hong Kong. 2009.

Khoo U.S., Molecular Genetics of the BRCA1 and BRCA2 genes in Chinese breast and ovarian cancer, Croucher Advanced Study Institute, Hong Kong. 2009.

Liao X., Siu K.Y., Wong E.S.Y., Ngan H.Y.S., Chan K.Y.Q., Li A.S.M., Khoo U.S. and Cheung A.N.Y., Hypermethylation of RAS effector related genes and DNA methyltransferase 1 expression in endometrial carcinogenesis, Int J Cancer. 2008, 123(2): 296-302.

Liao X., Chan Y.K., Chan I.L.S., Wong K.Y., Wong E.S.Y., Chan H.Y., Siu K.Y., Khoo U.S., Ngan H.Y.S. and Cheung A.N.Y., Kinesin family member 7 (KIF7) in endometrial and ovarian cancers , The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18 - 22 April 2009. . 2009.

Ngan E.S.W., Lang B.H.H., Liu T., Shum K.Y., So M.T., Lau K.C., Leon Y.Y., Cherny S.S., Tsai S.Y., Lo C.Y., Khoo U.S., Tam P.K.H. and Garcia-Barcelo M.M., A germline mutation (A339V) in thyroid transcription factor-1 (TITF-1/NKX2.1) in patients with multinodular goiter and papillary thyroid carcinoma, Journal of the National Cancer Institute. 2009, 101(3): 162-175.

Ting K.P., Wu L.H., Ip Y.C., Khoo U.S. and Chan Y.K., Mini-chromosome-maintenance-deficient 4 (MCM4) in breast cancer and its clinical significance (Oral presentation), The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18 - 22 April 2009. . 2009.

Researcher : Ko FCF

List of Research Outputs

Chan L.K., Ko F.C.F., Ng I.O.L. and Yam J.W.P., Deleted in liver cancer 1 (DLC1) utilizes a novel binding site for Tensin2 PTB domain interaction and is required for tumor-suppressive function, PLoS One. 2009, 4: e5572.

Ko F.C.F., Chan L.K., Ng I.O.L. and Yam J.W.P., Post-translational modification of Deleted in Liver Cancer 1 (DLC1) tumor suppressor, The 6th International Meeting Hepatocellular Carcinoma: Eastern and Western Experiences, Seoul, Korea. 2008.

Tse Y.T., Ko F.C.F., Lee K.W., Ngan E.S.W., Ng I.O.L. and Yam J.W.P., Upregulation of caveolin-1 in human hepatocellular carcinoma, American Association for Cancer Research 100th Annual Meeting, Denver, Colorado, USA, 2009.

Wong C.C.L., Wong C.M., Ko F.C.F., Chan L.K., Ching Y.P., Yam J.W.P. and Ng I.O.L., Deleted in liver cancer 1 (DLC1) negatively regulates Rho/ROCK/MLC pathway in hepatocellular carcinoma, PLoS One. 2008, 3: e2779.

Yam J.W.P., Ko F.C.F., Chan L.K. and Ng I.O.L., Functional implications of Akt phosphorylation of Deleted in Liver Cancer 1 (DLC1), American Association for Cancer Research 100th Annual Meeting, Denver, Colorado, USA. 2009.

Researcher : Ko KH

List of Research Outputs

Au W.S., Lu L., Tam S., Ko K.H., Chow B.K.C., He M.L., Ng S.M., Yeung C.M., Liu C.C., Kung H.F. and Lin M.C., Pluronic L‑81 Ameliorates Diabetic Symptoms In Db/db Mice Through Transcriptional Regulation Of Microsomal Triglyceride Transfer Protein, World Journal of Gasternology. 2009, 15(24): 2987-2994.

Lam Q.L.K., Ko K.H., Zheng B.J. and Lu L., Local BAFF gene silencing suppresses Th17 cell generation and ameliorates autoimmune arthritis, Proceedings of the National Academy of Sciences. 2008, 105(39): 14993-14998.

Lam Q.L.K., Ko K.H., Zheng B. and Lu L., Local BAFF gene silencing suppresses Th17-cell generation and ameliorates autoimmune arthritis, Proc Natl Acad Sci USA. 2008, 105(39): 14993-14998.

Lo C.K., Lam Q.L.K., Sun L., Wang S., Ko K.H., Xu H., Wu C.Y., Zheng B. and Lu L., Natural killer cell degeneration exacerbates experimental arthritis in mice via enhanced interleukin-17 production, Arthritis and Rheumatism. 2008, 58(9): 2700-2711.

Researcher : Kong SH

List of Research Outputs

Kong S.H., Siu K.Y., Chan H.Y., Jiang L., Tam K.F., Ngan H.Y.S., Le X.F. and Cheung A.N.Y., Overexpression of αPIX contributes to ovarian cancer metastasis, increased chemoresistance and poor prognosis., The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18 - 22 April 2009.. 2009.

Researcher : Kwok JSY

List of Research Outputs

Ha S.Y., Chan G.C.F., Kwok J.S.Y., Chiang A.K.S., Lee T.L. and Lau Y.L., Matched unrelated donor transplantation for Hong Kong patients with thalassaemia major, Chinese Blood and Marrow Transplantation Forum and Annual Scientific Meeting of Hong Kong Society of Haematology, Hong Kong, 27 February - 2 March 2009 (oral presentation). 2009, 49.

Lau E.Y.F., So S.Y., Chan E.Y.T., Kwok J.S.Y., Ma J.T.C. and Kung A.W.C., Methimazole-induced antineutrophil cytoplasmic antibody-associated diffuse alveolar haemorrhage in a Chinese woman with Graves' disease, Hong Kong Med J.. 2009, 15(3): 209-12.

Researcher : Lam AKY

List of Research Outputs

Pak K.C., Lam A.K.Y., Law S.Y.K. and Tang J.C.O., The inhibitory effect of Gleditsia sinensis on cyclooxygenase-2 expression in human esophageal squamous cell carcinoma, International Journal of Molecular Medicine. 2009, 23(1): 121-129.

Researcher : Lam CCK

List of Research Outputs

So J.C.C., Leung R.Y.Y., Yip S.F., Lam C.C.K. and Chan L.C., Invasive Streptococcus pneumoniae infection associated with hemolytic uremic syndrome in Chinese pediatric patients. , 50th American Society of Hematology Annual Meeting and Expositions, USA. 2008.

Yeung C.K., Trendell-Smith N.J., Mak H.K.F., Lam C.C.K. and Kwong Y.L., Cutaneous intravascular large B-cell lymphoma: Asian variant or not? , Clinical and Experimental Dermatology (2009, in press).. 2009.

Researcher : Lam CW

List of Research Outputs

LAU K.C. and Lam C.W., A fast and easy protocol increases the flexibility of a high density genotyping microarray in host genetics susceptibility study, The American Society of Human Genetics (ASHG), The Human Genome Organisation (HUGO) and Nature Publishing Group: Genetics and Genomics of Infectious Diseases March 21-24, 2009, The Ritz Carlton Millenia Hotel, Singapore. 2009.

Lam C.W., Advances in Cardiac Arrhythmias & Heart Failure Management, HK-IN-PACE 10th Annual Scientific Meeting, organized by Hong Kong Interhospital Network of Pacing and Cardiac Electrophysiology (HK-IN-PACE), October 12, 2008, Langham Hotel Ballroom, Tsimshatsui, Kowloon. 2008.

Lam C.W., DNA-based Diagnosis of Cardiac Arrhythmia in Paediatric Patients, Journal of the Hong Kong College of Cardiology. 2009, 17(Supp 1): 9.

Lam C.W., DNA-based Diagnosis of Cardiac Arrhythmia in Paediatric Patients, Seventeenth Annual Scientific Congress, Hong Kong College of Cardiology, June 26-28, 2009, Hong Kong. 2009.

Lam C.W., DNA-based diagnosis of neurological diseases, Scientific Programme - 21st Annual Scientific Meeting, The Hong Kong Neurological Society, November 16, 2008, Hong Kong. 2008.

Lam C.W., Lan L.C.L., Che C.M., Tam S., Wong S.S.Y., Chen Y., Jin J., Tao S.H., Tang X.M., Yuen K.Y. and Tam P.K.H., Diagnosis and spectrum of melamine-related renal disease: plausible mechanism of stone formation in humans, Clinica Chimica Acta. 2009, 402: 150-155.

Lam C.W., Editorial Board member, Clinica Chimica Acta. 2008.

Lam C.W., Editorial Board member, Journal of Chinese Clinical Medicine. 2008.

Lam C.W., Exam Cases Workshop, RCPA AACB Chemical Pathology Course 2009, Melbourne Convention Centre, Melbourne, Victoria, Australia, February 23-27, 2009. 2009.

Lam C.W., HKU Discovers the Mechanism of Kidney Stone Formation in Humans by Melamine , The University of Hong Kong. 2009.

Lam C.W., High Prevalence Rate of Wilson Disease in Hong Kong: 1 in 5400, Brainchild. 2009, 10(1).

Lam C.W., Lithium / Digoxin, RCPA AACB Chemical Pathology Course 2009, Melbourne Convention Centre, Melbourne, Victoria, Australia, February 23-27, 2009. 2009.

Lam C.W., Personalized Medicine and Molecular Diagnostics, The Ninth Chinese Laboratory Medicine Conference, Hong Kong Institute of Medical Laboratory Sciences, June 26-29, 2009, Hong Kong. 2009.

Lam C.W., Personalized Medicine, Hospital Authority Toxicology Service Scientific Conference 2009, March 21, 2009, Hong Kong. 2009.

Tang H.W., Ng K.M., Chui S.Y., Che C.M., Lam C.W., Yuen K.Y., Siu T.S., Lan L.C.L. and Chen X.Y., Analysis of Melamine Cyanurate in Urine Using Matrix-Assisted Laser Desorption / Ionization Mass Spectrometry , Analytical Chemistry. 2009, 81: 3676-3682.

Researcher : Lam QLK

List of Research Outputs

Lam Q.L.K., Best Abstract Award, Annual Scientific Meeting, The Hong Kong Society for Immunology . 2009.

Lam Q.L.K. and Lu L., Local BAFF Gene Silencing Suppresses Th17 Cell Generation and Ameliorates Autoimmune Arthritis, The Fourth Congress of the Federation of Immunology Societies of Asia-Oceania (FIMSA), Taiwan. 2008.

Lam Q.L.K., Ko K.H., Zheng B.J. and Lu L., Local BAFF gene silencing suppresses Th17 cell generation and ameliorates autoimmune arthritis, Proceedings of the National Academy of Sciences. 2008, 105(39): 14993-14998.

Lam Q.L.K., Ko K.H., Zheng B. and Lu L., Local BAFF gene silencing suppresses Th17-cell generation and ameliorates autoimmune arthritis, Proc Natl Acad Sci USA. 2008, 105(39): 14993-14998.

Lo C.K., Lam Q.L.K., Sun L., Wang S., Ko K.H., Xu H., Wu C.Y., Zheng B. and Lu L., Natural killer cell degeneration exacerbates experimental arthritis in mice via enhanced interleukin-17 production, Arthritis and Rheumatism. 2008, 58(9): 2700-2711.

Researcher : Lam SGS

List of Research Outputs

Yau T.O., Chan C.F., Lam S.G.S., Cheung O.F., Ching Y.P., Jin D., Sham M.H. and Ng I.O.L., Hepatocyte-specific activation of NF-KB does not aggravate chemical hepatocarcinogenesis in transgenic mice, The Journal of Pathology. 2008, 217: 353-361.

Researcher : Lau JKY

List of Research Outputs

Chan T.L., Yuen S.T., Kuiper R.P., Lee T.Y.H., Tsui W.Y., Lau J.K.Y., Li C., Chan K.W., Kong C.K., Chan A.S.Y., Ligtenberg M.J.L. and Leung S.Y., Deletion of the 3’ Exons of TACSTD1 Causes Hereditary Nonpolyposis Colorectal Cancer with MSH2 Gene Promoter Methylation, The 3rd Biennial Meeting of The International Society for Gastrointestinal Hereditary Tumours (InSiGHT), Dusseldorf, Germany. 2009.

Researcher : Lau WH

List of Research Outputs

Tse E.W.C., Leung R.Y.Y., Khong P.L., Lau W.H. and Kwong Y.L., Non-nasal natural killer cell lymphoma: not non-nasal after all, Annals of Hetmatology. 2009, 88: 185-187.

Researcher : Lee KW

List of Research Outputs

Lee K.W., The molecular mechanism of HCC metastasis, K C Wong Education Foundation Fund, Shanghai Jiao Tong University from 28 to 30th October. 2008.

Lee K.W., Castilho A.G., Sin S.L., Ma S.K.Y. and Ng I.O.L., The specific targeting of liver cancer stem cells by lupeol through PTEN modulation, American Association for Cancer Research. 2009.

Lee K.W., Wong KC Education Fund, 2008.

Ling M.T., Chiu Y.T., Lee K.W., Leung S.C., Fung K.L., Wang X., Wong K.F. and Wong Y.C., Id-1 induces proteasome-dependent degradation of the HBX protein, Journal of molecular Biology. 2008, 382: 34-43.

Ma S.K.Y., Chan K.W., Lee K.W., Tang K.H., Wo Y.H., Zheng B. and Guan X.Y., Aldehyde dehydrogenase discriminates the CD133 liver cancer stem cell populations, Molecular Cancer Research. 2008, 6: 1146-1153.

Ma S.K.Y., Chan Y.P., Lee K.W., Tang K.H., Ng I.O.L., Man K., To K.F., Zheng B., Chan K.W. and Guan X.Y., The role of miR-130b in the regulation of CD133+ cancer stem cells-driven hepatocellular carcinoma, The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18-22 April 2009.

Tang K.H., Ma S.K.Y., Lee K.W., Ng I.O.L., Man K., To K.F., Zheng B., Guan X.Y. and Chan K.W., CD133+ liver cancer stem cells promote tumor growth and angiogenesis through increased interleukin-8 secretion, The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18-22 April 2009.

Tse Y.T., Ko F.C.F., Lee K.W., Ngan E.S.W., Ng I.O.L. and Yam J.W.P., Upregulation of caveolin-1 in human hepatocellular carcinoma, American Association for Cancer Research 100th Annual Meeting, Denver, Colorado, USA, 2009.

Researcher : Lee MF

List of Research Outputs

Au L.K., Wong C.L., Lee M.F., Wong C.M. and Ng I.O.L., Overexpression of the histone methyltransferase Enhancer of Zeste Homolog 2 was involved in multistep hepatocarcinogenesis and metastasis of hepatocellular carcinoma, American Association for Cancer Research 100th Annual Meeting. Denvoer, CO, USA, 2009.

Chan D.W., Chan P.C.Y., Lee M.F. and Ng I.O.L., Genetic and epigenetic inactivation of T-cadherin in human hepatocellular carcinoma cells, International Journal of Cancer. wiley, 2008, 123: 1043-1052.

Lee M.F., Wong C.M. and Ng I.O.L., Hepatitis B virus-associated multistep hepatocarcinogenesis: a stepwise increase in allelic alterations, In: Cancer Research, 2008, 68 (14): 5988-5996.

Tung K.K., Wong C.M., Yau T.O., Lee M.F., Ching Y.P. and Ng I.O.L., HAI-2 is epigenetically downregulated in human hepatocellular carcinoma, and its Kunitz domain type 1 is critical for anti-invasive functions. , International Journal of Cancer. 2009, 124: 1811.

Wong C.L., Wong C.M., Tung E.K., Lee M.F., Man K. and Ng I.O.L., Rho-kinase 2 (ROCK2) is involved in hepatocellular carcinoma progression, metastasis and invasion, Second Annual Meeting, International Liver Cancer Association, Chicago, USA. 2008.

Researcher : Lee TYH

List of Research Outputs

Chan T.L., Yuen S.T., Kuiper R.P., Lee T.Y.H., Tsui W.Y., Lau J.K.Y., Li C., Chan K.W., Kong C.K., Chan A.S.Y., Ligtenberg M.J.L. and Leung S.Y., Deletion of the 3’ Exons of TACSTD1 Causes Hereditary Nonpolyposis Colorectal Cancer with MSH2 Gene Promoter Methylation, The 3rd Biennial Meeting of The International Society for Gastrointestinal Hereditary Tumours (InSiGHT), Dusseldorf, Germany. 2009.

Ligtenberg M.J., Kuiper R.P., Chan T.L., Goossens M., Hebeda K.M., Voorendt M., Lee T.Y.H., Bodmer D., Hoenselaar E., Hendriks-Cornelissen S.J., Tsui W.Y., Kong C.K., Brunner H.G., van Kessel A.G., Yuen S.T., van Krieken J.H., Leung S.Y. and Hoogerbrugge N., Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3' exons of TACSTD1, Nat Genet. 2009, 41(1): 112-7.

Researcher : Leung LH

List of Research Outputs

Leung L.H., Tam I.Y., Tin P.C., Chua D.T.T., Sihoe A.D.L., Cheung L.C., Ho J.C.M., Chung L.P. and Wong M.P., Src Promotes Survival and Invasion of Lung Cancers with Epidermal Growth Factor Receptor Abnormalities and Is a Potential Candidate for Molecular-Targeted Therapy., Molecular Cancer Research. 2009, 7(6): 923-32.

Leung L.H., University of Hong Kong/China Medical Board Grants 2007/2008 Support training at the Nevada Cancer Institute (NVCI), Las Vegas, USA HKD 63, 872 , 2008.

So K.T., Tam I.Y., Leung L.H., Tin P.C., Wong W.S., Sihoe A.D.L., Cheng L.C., Chung L.P. and Wong M.P., Mutational analysis of EGFR-related genes in non-small cell lung cancer (Poster), American Association for Cancer Research Annual Meeting, 2009 April 18-22, 2009, Denver, Colorado, the United State . 2009.

Tam I.Y., Leung L.H., Tin P.C., Chua D.T.T., Sihoe A.D.L., Cheng L.C., Chung L.P. and Wong M.P., EGFR mutants containing rare EGFR mutant types show reduced response to in-vitro gefitinib compared to common activating missense mutations (Poster), American Association for Cancer Research Annual Meeting, 2009 April 18-22, 2009, Denver, Colorado, the United State . 2009.

Wong W.S., Leung L.H., Tin P.C., Sihoe A.D.L., Cheng L.C., Chung L.P. and Wong M.P., ALK kinase domain is aberrantly expressed but not mutated in Chinese non-small cell lung cancer from male smokers with squamous cell carcinoma (Poster), American Association for Cancer Research Annual Meeting, 2009 April 18-22, 2009, Denver, Colorado, the United State . 2009.

Wong W.S., Leung L.H., So K.T., Tam Y.S.I., Sihoe A.D.L., Cheng L.C., Ho K.K., Au J.S., Chung L.P. and Wong M.P., The Eml4-alk Fusion Gene Is Involved In Various Histologic Types Of Lung Cancers From Nonsmokers With Wild-type Egfr And Kras, Cancer. 2009, 115: 1723-1733.

Researcher : Leung RYY

List of Research Outputs

Au W.Y., Wong K.Y., Leung R.Y.Y. and Tong A.C.K., Isolated gingival relapse of acute lymphoblastic leukemia after transplantation, Journal of Oral Pathology & Medicine. 2008, 37(4): 249-251.

Hwang Y.Y., Wong K.Y., Leung R.Y.Y., Wong S.H., Chan S.C., Srivastava G. and Au W.Y., Post-rituximab Burkitt transformation of PTLD: loss of CD20 expression accompanied by a switch in light-chain expression, Ann Hematol. 2009, [Epub ahead of print].

So J.C.C., Leung R.Y.Y., Yip S.F., Lam C.C.K. and Chan L.C., Invasive Streptococcus pneumoniae infection associated with hemolytic uremic syndrome in Chinese pediatric patients. , 50th American Society of Hematology Annual Meeting and Expositions, USA. 2008.

Tse E.W.C., Leung R.Y.Y., Khong P.L., Lau W.H. and Kwong Y.L., Non-nasal natural killer cell lymphoma: not non-nasal after all, Annals of Hetmatology. 2009, 88: 185-187.

Researcher : Leung SY

List of Research Outputs

Chan T.L., Yuen S.T., Kuiper R.P., Lee T.Y.H., Tsui W.Y., Lau J.K.Y., Li C., Chan K.W., Kong C.K., Chan A.S.Y., Ligtenberg M.J.L. and Leung S.Y., Deletion of the 3’ Exons of TACSTD1 Causes Hereditary Nonpolyposis Colorectal Cancer with MSH2 Gene Promoter Methylation, The 3rd Biennial Meeting of The International Society for Gastrointestinal Hereditary Tumours (InSiGHT), Dusseldorf, Germany. 2009.

Fan P.Y.S., Lui P.C., Tam K.Y., Hung K.N., Ng H.K. and Leung S.Y., A 33-year-old Chinese woman with a left frontal tumor, Brain Pathol.. 2009, 19(2): 337-40.

Leung S.Y., Colorectal cancer carcinogenesis & genetic predisposition, Translating Cancer Cell Biology to Clinical Practice, Cancer Research Initiatives Foundation (CARIF), Kula Lumpur, Malaysia . 2008.

Leung S.Y., Colorectal cancer – Implications of genetic testing on clinical management, Translating Cancer Cell Biology to Clinical Practice, Cancer Research Initiatives Foundation (CARIF), Kula Lumpur, Malaysia . 2008.

Leung S.Y., Gene Expression Profiling of Human Colon Tops and Basal Crypts - Identification of BMP Antagonists as Intestinal Stem Cell Niche Factors, 46. The 15th Hong Kong International Cancer Congress and the 5th Annual Meeting Centre for Cancer Research, Li Ka Shing Faculty of Medicine, The University of Hong Kong . 2008.

Leung S.Y., Keynote Session for Best Research Output Awardees “Genetic and Epigenetic Mechanisms for Inactivation of DNA Mismatch Repair Genes in Hereditary Nonpolyposis Colorectal Cancer”, Frontiers in Biomedical Research, Li Ka Shing Faculty of Medicine, The University of Hong Kong . 2008.

Ligtenberg M.J., Kuiper R.P., Chan T.L., Goossens M., Hebeda K.M., Voorendt M., Lee T.Y.H., Bodmer D., Hoenselaar E., Hendriks-Cornelissen S.J., Tsui W.Y., Kong C.K., Brunner H.G., van Kessel A.G., Yuen S.T., van Krieken J.H., Leung S.Y. and Hoogerbrugge N., Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3' exons of TACSTD1, Nat Genet. 2009, 41(1): 112-7.

Sung J.J., Lau J.Y., Young G.P., Sano Y., Chiu H.M., Byeon J.S., Yeoh K.G., Goh K.L., Sollano J., Rerknimitr R., Matsuda T., Wu K.C., Ng S., Leung S.Y., Makharia G., Chong V.H., Ho K.Y., Brooks D., Lieberman D.A. and Chan F.K., Asia Pacific consensus recommendations for colorectal cancer screening, Gut. 2008, 57(8): 1166-76.

van Haaften G., Dalgliesh G.L., Davies H., Chen L., Bignell G., Greenman C., Edkins S., Hardy C., O'Meara S., Teague J., Butler A., Hinton J., Latimer C., Andrews J., Barthorpe S., Beare D., Buck G., Campbell P.J., Cole J., Forbes S., Jia M., Jones D., Kok C.Y., Leroy C., Lin M.L., McBride D.J., Maddison M., Maquire S., McLay K., Menzies A., Mironenko T., Mulderrig L., Mudie L., Pleasance E., Shepherd R., Smith R., Stebbings L., Stephens P., Tang G., Tarpey P.S., Turner R., Turrell K., Varian J., West S., Widaa S., Wray P., Collins V.P., Ichimura K., Law S.Y.K., Wong J., Yuen S.T., Leung S.Y., Tonon G., DePinho R.A., Tai Y.T., Anderson K.C., Kahnoski R.J., Massie A., Khoo S.K., Teh B.T., Stratton M.R. and Futreal P.A., Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer, Nature Genetics. 2009, 41(5): 521-523.

Researcher : Li C

List of Research Outputs

Chan T.L., Yuen S.T., Kuiper R.P., Lee T.Y.H., Tsui W.Y., Lau J.K.Y., Li C., Chan K.W., Kong C.K., Chan A.S.Y., Ligtenberg M.J.L. and Leung S.Y., Deletion of the 3’ Exons of TACSTD1 Causes Hereditary Nonpolyposis Colorectal Cancer with MSH2 Gene Promoter Methylation, The 3rd Biennial Meeting of The International Society for Gastrointestinal Hereditary Tumours (InSiGHT), Dusseldorf, Germany. 2009.

Researcher : Liao X

List of Research Outputs

Au C.W.H., Siu K.Y., Liao X., Wong E.S.Y., Ngan H.Y.S., Tam K.F., Chan D.C.W., Chan Q.K.Y. and Cheung A.N.Y., Tyrosine kinase B receptor and BDNF expression in ovarian cancers - Effect on cell migration, angiogenesis and clinical outcome, Cancer Letters. 2009, 281: 151-161.

Liao X., Siu K.Y., Au W.H., Chan K.Y.Q., Chan H.Y., Wong E.S.Y., Ip P.P.C., Ngan H.Y.S. and Cheung A.N.Y., Aberrant activation of hedgehog signaling pathway contributes to endometrial carcinogenesis through β-catenin., Modern Pathol.. 2009, 22: 839-847.

Liao X., Siu K.Y., Au W.H., Wong E.S.Y., Chan H.Y., Ip P.P.C., Ngan H.Y.S. and Cheung A.N.Y., Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation., Carcinogenesis. 2009, 30: 131-140.

Liao X., Siu K.Y., Wong E.S.Y., Ngan H.Y.S., Chan K.Y.Q., Li A.S.M., Khoo U.S. and Cheung A.N.Y., Hypermethylation of RAS effector related genes and DNA methyltransferase 1 expression in endometrial carcinogenesis, Int J Cancer. 2008, 123(2): 296-302.

Liao X., Chan Y.K., Chan I.L.S., Wong K.Y., Wong E.S.Y., Chan H.Y., Siu K.Y., Khoo U.S., Ngan H.Y.S. and Cheung A.N.Y., Kinesin family member 7 (KIF7) in endometrial and ovarian cancers , The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18 - 22 April 2009. . 2009.

Tse K.Y., Liu V.W.S., Chan D.W., Chiu P.M., Tam K.F., Chan K.K.L., Liao X., Cheung A.N.Y. and Ngan H.Y.S., Epigenetic alteration of the metallothionein 1E gene in human endometrial carcinomas, Tumor Biology. 2009, 30: 93-99.

Zhang H., Xue W.C., Siu K.Y., Liao X., Ngan H.Y.S. and Cheung A.N.Y., P63 Expression in Gestational Trophoblastic Disease: Correlation With Proliferation and Apoptotic Dynamics., Int. J. Gynecol. Pathol. . 2009, 28: 172-178.

Researcher : Liao X

List of Research Outputs

Researcher : Liu W

List of Research Outputs

Chan Y.K., Liu W., Long J.R., Yip S.P., Chan S.Y., Shu X.O., Chua D.T.T., Cheung A.N.Y., Ching C.Y.J., Cai H., Au G.K.H., Chan M., Foo W., Ngan H.Y.S., Gao Y.T., Ngan E.S.W., Garcia-Barcelo M.M., Zheng W. and Khoo U.S., Functional polymorphisms in the BRCA1 promoter influence transcription and are associated with decreased risk for breast cancer in Chinese women., J Med Genet. 2009, 46: 32-39.

Chan Y.K., Liu W., Long J.R., Yip S.P., Chan S.Y., Shu X.O., Chua D.T.T., Cheung A.N.Y., Ching J.C.Y., Cai H., Au G.K.H., Chan M., Foo W., Ngan H.Y.S., Gao Y.T., Ngan E.S.W., Garcia-Barcelo M.M., Zheng W.E.I. and Khoo U.S., Functional polymorphisms in the promoter of BRCA1 influences transcription and are associated with decreased risk for breast cancer in Chinese women, Journal of Medical Genetics. 2009, 46(1): 32-39.

Researcher : Liu W

List of Research Outputs

Researcher : Lo CK

List of Research Outputs

Lo C.K., Lam Q.L.K., Sun L., Wang S., Ko K.H., Xu H., Wu C.Y., Zheng B. and Lu L., Natural killer cell degeneration exacerbates experimental arthritis in mice via enhanced interleukin-17 production, Arthritis and Rheumatism. 2008, 58(9): 2700-2711.

Researcher : Lo JCY

List of Research Outputs

Siu Y.L., Teoh K.T., Lo J.C.Y., Chan C.M., Kien F.S., Escriou N., Tsao G.S.W., Nicholls J.M., Altmeyer R.M., Peiris J.S.M., Bruzzone R. and Nal-Rogier B.T.M., The M, E and N structural proteins of the SARS coronavirus are required for efficient assembly, trafficking and release of virus-like particles., Journal of Virology. 2008.

Siu Y.L., Teoh K.T., Lo J.C.Y., Chan C.M., Kien F.S., Escriou N., Tsao G.S.W., Nicholls J.M., Altmeyer R.M., Peiris J.S.M., Bruzzone R. and Nal-Rogier B.T.M., The M, E, And N Structural Proteins Of The Severe Acute Respiratory Syndrome Coronavirus Are Required For Efficient Assembly, Trafficking, And Release Of Virus-like Particles., Journal of Virology. 2008, 82(22): 11318-30.

Researcher : Loong F

List of Research Outputs

Chim J.C.S., Loong F., Ng W.K. and Kwong Y.L., Use of fludarabine-containing chemotherapeutic regimen results in durable complete remission of subcutaneous panniculitis-like T-cell lymphoma, American Journal of Clinical Dermatology. 2008, 9(6): 396-8.

Researcher : Lu L

List of Research Outputs

Au W.S., Lu L., Tam S., Ko K.H., Chow B.K.C., He M.L., Ng S.M., Yeung C.M., Liu C.C., Kung H.F. and Lin M.C., Pluronic L‑81 Ameliorates Diabetic Symptoms In Db/db Mice Through Transcriptional Regulation Of Microsomal Triglyceride Transfer Protein, World Journal of Gasternology. 2009, 15(24): 2987-2994.

Au W.S., Lu L., Yeung C.M., Liu C.C., Wong G.W., Lai L., Kung H.F. and Lin M.C., The HNF-1a Binding Element within the Promoter of MTP Gene is Crucial for MTP Basal Expression and Insulin Responsiveness, Journal of Molecular Endocrinology. 2008, 41: 229-238.

Lam Q.L.K. and Lu L., Local BAFF Gene Silencing Suppresses Th17 Cell Generation and Ameliorates Autoimmune Arthritis, The Fourth Congress of the Federation of Immunology Societies of Asia-Oceania (FIMSA), Taiwan. 2008.

Lam Q.L.K., Ko K.H., Zheng B.J. and Lu L., Local BAFF gene silencing suppresses Th17 cell generation and ameliorates autoimmune arthritis, Proceedings of the National Academy of Sciences. 2008, 105(39): 14993-14998.

Lam Q.L.K., Ko K.H., Zheng B. and Lu L., Local BAFF gene silencing suppresses Th17-cell generation and ameliorates autoimmune arthritis, Proc Natl Acad Sci USA. 2008, 105(39): 14993-14998.

Lo C.K., Lam Q.L.K., Sun L., Wang S., Ko K.H., Xu H., Wu C.Y., Zheng B. and Lu L., Natural killer cell degeneration exacerbates experimental arthritis in mice via enhanced interleukin-17 production, Arthritis and Rheumatism. 2008, 58(9): 2700-2711.

Lu L., Autoimmune arthritis and its therapeutic targeting by gene silencing, The 1st Chinese Cross-Strait Immunology Summit Conference, Chinese Society for Immunology, Guangzhou, China. 2009.

Lu L., Regulation of B cell and dendritic cell development, Annual Scientific Meeting of Hong Kong Institute of Laboratory Sciences, Hong Kong. 2008.

Lu L., Regulation of B cell and dendritic cell development, Nanjing University, Jiangsu, China. 2008.

Wu P., Wu J., Liu S., Han X., Lu J., Shi Y., Wang J., Lu L. and Cao X., TLR9/TLR7-triggered downregulation of BDCA2 expression on human plasmacytoid dendritic cells from healthy individuals and lupus patients., In: Wu P, J Wu, S Liu; X Han; J Lu, , Clinical Immunology. 2008, 129(1): 40-8.

Zheng B., Zhou J., Huang J., Lu L. and Yuen K.Y., An IFN-a/b receptor 1 promoter variant and hepatitis B virus synergistically increase the susceptibility to chronic hepatitis B, 2008 International Meeting: The Molecular Biology of Hepatitis B Viruses. San Diego, California, USA, 2008.

Zhou J., Chen D., Poon K.M., Zeng Y., Ng F., Lu L., Huang J., Yuen K.Y. and Zheng B., A comprehensive study of interferon-γ receptor 1 gene polymorphisms and susceptibility to chronic hepatitis B virus infection. , Immunogenetics. 2009, 61(6): 423-430.

Zhou J., Smith D.K., Lu L., Poon K.M., Ng F., Chen D., Huang J., Yuen K.Y. and Zheng B., A non-synonymous single nucleotide polymorphism in IFNAR1 affects susceptibility to chronic hepatitis B virus infection, J Viral Hepat. 2009, 16(1): 45-52.

Zhou J., Huang J., Poon V.K.M., Chen D.Q., Chan C.C.S., Ng F., Guan X.Y., Watt R.M., Lu L., Yuen K.Y. and Zheng B., Functional dissection of an IFN-α/β receptor 1 promoter variant that confers higher risk to chronic hepatitis B virus infection , Journal of Hepatology. 2009, V51(2): 322-32.

Researcher : Ma ESK

List of Research Outputs

Au W.Y., So J.C.C., Ma E.S.K. and Lie A.K.W., Glucose-6-phosphate-dehydrogenase deficiency and haematopoietic stem cell transplantation in Chinese patients, Hong Kong Med J . 2009, 15(3 Suppl 3): 35-8.

Gibney G.T., Panhuysen C.I.M., So J.C.C., Ma E.S.K., Ha S.Y., Li C.K., Lee A.C.W., Li C.K., Yuen H.L., Lau Y.L., Johnson D.M., Farrell J.J., Bisbee A.B., Farrer L.A., Steinberg M.H., Chan L.C. and Chui D.H.K., Variation and heritability of Hb F and F-cells among b-thalassemia heterozygotes in Hong Kong, American Journal of Hematology. 2008, 83(6): 458-464.

Sedgewick A.E., Timofeev N., Sebastiani P., So J.C.C., Ma E.S.K., Chan L.C., Fucharoen G., Fucharoen S., Barbosa C.G., Vardarajan B.N., Farrer L.A., Baldwin C.T., Steinberg M.H. and Chui D.H.K., BCL11A is a major HbF quantitative trait locus in three different populations with beta-hemoglobinopathies, Blood Cells Mol Dis. 2008, 41(3): 255-8.

So J.C.C., Wan T.S.K., Ma E.S.K. and Chan L.C., An unbalanced translocation, der(17)t(1;17)(p13;p11.2), leads to heterozygous loss of TP53 and is associated with clinical evolution in myelodysplastic syndrome, Br J Biomed Sci. 2008, 65(1): 36-38.

So J.C.C., Song Y., Tsang S.T.Y., Tang L.F., Chan A.Y.W., Ma E.S.K. and Chan L.C., The HBS1L-MYB intergenic region on chromosome 6q23 is a quantitative trait locus controlling fetal haemoglobin level in carries of β-thalassaemia, J Med Gen. 2008, 45(11): 745-51.

Sun Q., So J.C.C., Yip S.F., Wan T.S.K., Ma E.S.K. and Chan L.C., Functional alterations of Lin-CD34+CD38+ cells in chronic myelomonocytic leukemia and on progression to acute leukemia, Leuk Res. 2008, 32(9): 1374-1381.

Researcher : Ma SKY

List of Research Outputs

Chan H.M., Chen L., Ma S.K.Y., Hu L., Wang J. and Guan X.Y., CHD1L contributes to hepatocarcinogenesis by transcriptionally activating TCTP-mediated mitotic defects and chromosome missegregation, American Association for Cancer Research. 2009.

Chen L., Hu L., Chan H.M., Tsao G.S.W., Huo K.K., Fu L., Ma S.K.Y., Zheng B. and Guan X.Y., Chromodomain helicase/adenosine triphosphatase DNA binding protein 1-like (CHD1l) gene suppresses the nucleus-to-mitochondria translocation of nur77 to sustain hepatocellular carcinoma cell survival., Hepatology. 2009, 50: 122-129.

Lee K.W., Castilho A.G., Sin S.L., Ma S.K.Y. and Ng I.O.L., The specific targeting of liver cancer stem cells by lupeol through PTEN modulation, American Association for Cancer Research. 2009.

Ma S.K.Y., Chan K.W., Lee K.W., Tang K.H., Wo Y.H., Zheng B. and Guan X.Y., Aldehyde dehydrogenase discriminates the CD133 liver cancer stem cell populations, Molecular Cancer Research. 2008, 6: 1146-1153.

Ma S.K.Y., Cancer stem cells in the liver - The CD133 story, The 15th Hong Kong International Liver Congress (HKICC) The 5th Annual Meeting Centre for Cancer Research . 2008.

Ma S.K.Y., Chan Y.P., Woolcock B., Hu L., Wong K.Y., Ling M.T., Bainbridge T., Webber D., Chan H.M., Guan X.Y., Lam W., Vielkind J. and Chan K.W., DNA fingerprinting tags novel altered chromosomal regions and identifies the involvement of SOX5 in the progression of prostate cancer, International Journal of Cancer. 2009, 124: 2323-2332.

Ma S.K.Y., Hong Kong Young Scientist Award (Life Sciences Panel), Hong Kong Institution of Science. 2008.

Ma S.K.Y., Chan K.W. and Guan X.Y., In search of liver cancer stem cells, Stem Cell Reviews. 2008, 4: 179-192.

Ma S.K.Y., Chan Y.P., Lee K.W., Tang K.H., Ng I.O.L., Man K., To K.F., Zheng B., Chan K.W. and Guan X.Y., The role of miR-130b in the regulation of CD133+ cancer stem cells-driven hepatocellular carcinoma, The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18-22 April 2009.

Tang K.H., Ma S.K.Y., Lee K.W., Ng I.O.L., Man K., To K.F., Zheng B., Guan X.Y. and Chan K.W., CD133+ liver cancer stem cells promote tumor growth and angiogenesis through increased interleukin-8 secretion, The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18-22 April 2009.

Researcher : Ng IOL

List of Research Outputs

Au L.K., Wong C.M. and Ng I.O.L., Deregulation of Enhancer of Zeste Homolog 2 (EZH2) in Hepatocellular Carcinoma (HCC), 15th Hong Kong International Cancer Congress. 2008.

Au L.K., Wong C.L., Lee M.F., Wong C.M. and Ng I.O.L., Overexpression of the histone methyltransferase Enhancer of Zeste Homolog 2 was involved in multistep hepatocarcinogenesis and metastasis of hepatocellular carcinoma, American Association for Cancer Research 100th Annual Meeting. Denvoer, CO, USA, 2009.

Chan D.W., Chan P.C.Y., Lee M.F. and Ng I.O.L., Genetic and epigenetic inactivation of T-cadherin in human hepatocellular carcinoma cells, International Journal of Cancer. wiley, 2008, 123: 1043-1052.

Chan L.K., Ko F.C.F., Ng I.O.L. and Yam J.W.P., Deleted in liver cancer 1 (DLC1) utilizes a novel binding site for Tensin2 PTB domain interaction and is required for tumor-suppressive function, PLoS One. 2009, 4: e5572.

Chang Y.K., Yang W., Zhao M., Mok C.C., Chan T.M., Wong R.M.Y., Lee K.W., Mok T.M.Y., Wong S.N., Ng I.O.L., Lee T.L., Ho M.H.K., Lee P.P.W., Wong W.H.S., Lau C.S., Sham P.C. and Lau Y.L., Association of BANK1 and TNFSF4 with systemic lupus erythematosus in Hong Kong Chinese, Genes & Immunity (Advance online publication). 2009, 10: 414-420.

Ching Y.P., Liu M.H.F., Lee C.W. and Ng I.O.L., The tumor suppressive function of AMPK in Hepatocellular Carcinoma, In: FASEB Summer Research Conferences, AMPK: In Sickness and Health From Molecule to Man. 2008.

Hwang Y.Y., Leung A.Y.H., Ng I.O.L., Chan G.S.W., Chan K.W., Tse E.W.C. and Kwong Y.L., Protein-Losing Enteropathy Due to T-Cell Large Granular Lymphocyte Leukemia, Journal of Clinical Oncology. 2009, 27(12): 2097-8.

Ko F.C.F., Chan L.K., Ng I.O.L. and Yam J.W.P., Post-translational modification of Deleted in Liver Cancer 1 (DLC1) tumor suppressor, The 6th International Meeting Hepatocellular Carcinoma: Eastern and Western Experiences, Seoul, Korea. 2008.

Lee K.W., Castilho A.G., Sin S.L., Ma S.K.Y. and Ng I.O.L., The specific targeting of liver cancer stem cells by lupeol through PTEN modulation, American Association for Cancer Research. 2009.

Lee M.F., Wong C.M. and Ng I.O.L., Hepatitis B virus-associated multistep hepatocarcinogenesis: a stepwise increase in allelic alterations, In: Cancer Research, 2008, 68 (14): 5988-5996.

Luk J., Xu M., Yao T.J., Ng I.O.L., Poon R.T.P. and Fan S.T., YAP is an independent prognostic marker associated with tumor recurrence of hepatocellular carcinoma, Joint Metastasis Research Society - the American Association for Cancer Research Conference on Metastasis, Vancouver, B.C., Canada, 3 - 7 August 2008.

Ma S.K.Y., Chan Y.P., Lee K.W., Tang K.H., Ng I.O.L., Man K., To K.F., Zheng B., Chan K.W. and Guan X.Y., The role of miR-130b in the regulation of CD133+ cancer stem cells-driven hepatocellular carcinoma, The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18-22 April 2009.

Ng I.O.L., Academic Editor, PLoS ONE, 2009.

Ng I.O.L., Asian Journal of Oral and Maxillofacial Surgery. 2008.

Ng I.O.L., Asian Journal of Surgery. 2008.

Ng I.O.L., Associate Editor, Liver International (Official journal of International Association for the Study of the Liver) . 2008.

Ng I.O.L., Carcinogenesis of hepatocellular carcinoma, 2008 International Liver Cancer Symposium, Seoul, Korea. 2008.

Ng I.O.L., Genes and Cancer, 2009.

Ng I.O.L., HBV-associated hepatocarcinogenesis and ROCK2 in HCC, Laennac Society meeting 2008. 2008.

Ng I.O.L., HBV-associated hepatocarcinogenesis and ROCK2 in HCC, Laennac Society meeting 2008, Padua, Italy. 2008.

Ng I.O.L., HBx and HCC, Asian Pacific Association for the Study of Liver. 2009.

Ng I.O.L., Hepatology. 2009.

Ng I.O.L., Journal of Gastroenterology and Hepatology. 2008.

Ng I.O.L., Liver cancer as a curable/deadly disease from the perspective of histopathology and research in tumour characteristics, Consultants’ Meeting on development of guidelines for the palliative management of common cancers using radiotherapy in limited resource settings: liver cancer, IAEA Headquarters, The United Nations, Vienna, Austria. 2008.

Ng I.O.L., Molecular basis of cancer – tumor suppressor genes, Yongsei University, Seoul, Korea. 2008.

Ng I.O.L., Molecular pathology and genetic alterations in liver cancer, Mini-symposium, Institute of Biochemistry and Cell Biology, SIBS, Shanghai. 2008.

Ng I.O.L., Molecular pathology and genetic alterations in liver cancer, Singapore Cancer Symposium, Institute of Molecular and Cell Biology, Singapore. 2008.

Ng I.O.L., Mrs. Gordon Wu Exchange Professorship, The University of Hong Kong. 2008.

Ng I.O.L., Outstanding Research Student Supervisor Award 2007-2008, The University of Hong Kong. 2009.

Sze M.F., Ching Y.P., Jin D. and Ng I.O.L., Role of a novel splice variant of mitotic arrest deficient 1 (MAD1), MAD1beta, in mitotic checkpoint control in liver cancer, In: American Association for Cancer Research, Cancer Research. 2008, 68: 9194-9201.

Tang K.H., Ma S.K.Y., Lee K.W., Ng I.O.L., Man K., To K.F., Zheng B., Guan X.Y. and Chan K.W., CD133+ liver cancer stem cells promote tumor growth and angiogenesis through increased interleukin-8 secretion, The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18-22 April 2009.

Tse Y.T., Ko F.C.F., Lee K.W., Ngan E.S.W., Ng I.O.L. and Yam J.W.P., Upregulation of caveolin-1 in human hepatocellular carcinoma, American Association for Cancer Research 100th Annual Meeting, Denver, Colorado, USA, 2009.

Tung K.K., Wong C.M., Yau T.O., Lee M.F., Ching Y.P. and Ng I.O.L., HAI-2 is epigenetically downregulated in human hepatocellular carcinoma, and its Kunitz domain type 1 is critical for anti-invasive functions. , International Journal of Cancer. 2009, 124: 1811.

Wong C.C.L., Wong C.M., Ko F.C.F., Chan L.K., Ching Y.P., Yam J.W.P. and Ng I.O.L., Deleted in liver cancer 1 (DLC1) negatively regulates Rho/ROCK/MLC pathway in hepatocellular carcinoma, PLoS One. 2008, 3: e2779.

Wong C.L. and Ng I.O.L., Rho-kinase 2 (ROCK2) is involved in hepatocellular carcinoma progression, metastasis and invasion, AACR Conference on Metastasis, Vancouver. 2008.

Wong C.L., Wong C.M., Tung E.K., Lee M.F., Man K. and Ng I.O.L., Rho-kinase 2 (ROCK2) is involved in hepatocellular carcinoma progression, metastasis and invasion, Second Annual Meeting, International Liver Cancer Association, Chicago, USA. 2008.

Wong C.L., Wong C.M., Tung K.K., Man K. and Ng I.O.L., Rho-kinase 2 is frequently overexpressed in hepatocellular carcinoma and involved in tumor invasion., Hepatology. 2009, 49 (5): 1583-1594.

Wong C.M. and Ng I.O.L., Overexpression of histone methyltransferases SUV39H1 and SUV39H2 in hepatocellular carcinoma, American Association for Cancer Research 100th Annual Meeting. Denver, CO, USA, 2009.

Xu Z., Yao T.J., Lee P.Y., Ng I.O.L., Chan Y.T., Zender L., Lowe S.W., Poon R.T.P. and Luk J.M.C., Yes-associated protein is an independent prognostic marker in hepatocellular carcinoma, Cancer. 2009, 115(19): 4576-4585.

Yam J.W.P., Ko F.C.F., Chan L.K. and Ng I.O.L., Functional implications of Akt phosphorylation of Deleted in Liver Cancer 1 (DLC1), American Association for Cancer Research 100th Annual Meeting, Denver, Colorado, USA. 2009.

Yam J.W.P., Tse Y.T. and Ng I.O.L., Role and significance of focal adhesion proteins in hepatocellular carcinoma, J Gastroenterol Hepatol. 2009, 24: 520-530.

Yang W., Zhao M., Hirankarn N., Lau W.C.S., Mok C.C., Chan D.T.M., Wong R.W.S., Lee G.K.W., Mok T.M.Y., Wong S.N., Avihingsanon Y., Ng I.O.L., Lee T.L., Ho M.H.K., Lee P.P.W., Wong W.H.S., Sham P.C. and Lau Y.L., ITGAM is associated with disease susceptibility and renal nephritis of systemic lupus erythematosus in Hong Kong Chinese and Thai, Human Molecular Genetics. 2009, 18(11): 2063-2070.

Yau T.O., Chan C.F., Lam S.G.S., Cheung O.F., Ching Y.P., Jin D., Sham M.H. and Ng I.O.L., Hepatocyte-specific activation of NF-KB does not aggravate chemical hepatocarcinogenesis in transgenic mice, The Journal of Pathology. 2008, 217: 353-361.

Researcher : Nicholls JM

List of Research Outputs

Chua D.T.T., Wei W.I., Wong M.P., Sham J.S.T., Nicholls J.M. and Au G.K.H., Phase II study of gefitinib for the treatment of recurrent and metastatic nasopharyngeal carcinoma, Head & Neck. 2008, 30(7): 863-7.

Kwong D.L.W., Law S.Y.K., Tong K.H., Wong K.H. and Nicholls J.M., COX-2 inhibition in combination with preoperative chemoradiation for CA esophagus (Abstract), Annual Meeting of the American Society of Clinical Oncology (ASCO), Orlando, USA, 29 May - 2 June. 2009.

Lee M.Y., Cheung C.Y., Nicholls J.M. and Peiris J.S.M., Hyper-induction of COX-2-medicated proinflammatory cascade: A mechanism for the pathogenesis of avian influenza H5N1 infection , CYTOKINE. 2008, 43(3): 259.

Lee M.Y., Cheung C.Y., Nicholls J.M., Hui P.Y., Leung C.Y.H., Uiprasertkul M., Tipoe G.L., Lau Y.L., Poon L.L.M., Ip N.Y., Guan Y. and Peiris J.S.M., Hyperinduction of Cyclooxygenase-2-Mediated Proinflammatory Cascade: A Mechanism for the Pathogenesis of Avian Influenza H5N1 Infection, The Journal of Infectious Diseases. 2008, 198(4): 525-35.

Li O.T.W., Chan M.C.W., Leung C.S.W., Chan W.Y., Guan Y., Nicholls J.M. and Poon L.L.M., Full factorial analysis of Mammalian and avian influenza polymerase subunits suggests a role of an efficient polymerase for virus adaptation., In: Li OT, Chan MC, Leung CS, Chan RW, Guan Y, Nicholls JM, Poon LL., PLoS ONE. 2009, 21;4(5): e5658.

Ngan E.S.W., Sit F.Y.L., Lee K.Y., Miao X., Yuan Z.W., Wang W.L., Nicholls J.M., Wong K.K.Y. and Tam P.K.H., Prokineticin signaling in neuroblastoma, 青年醫師優秀論文獎, The 3rd National Pediatric Surgical Oncology Conference and the 3rd Cross-strait Symposium on Pediatric Oncology, Shanghai, China, 10-13 October 2008. 2008.

Ngan E.S.W., Sit Y.L.F., Yuan Z., Wang W., Nicholls J.M., Wong K.K.Y. and Tam P.K.H., Prokineticin signaling in neuroblastoma, The 3rd National Pediatric Surgical Oncology Conference and the 3rd Cross-strait Symposium on Pediatric Oncology, Shanghai, China, 10-13 October 2008.

Nicholls J.M., Chan M.C.W., Chan W.Y., Cheung C.Y., Kwong D.L.W., Wong M.P., Poon L.L.M., Tsao G.S.W. and Guan Y., 2008 Research Output Prize/Faculty Outstanding Research Output Award, The University of Hong Kong. 2008.

Nicholls J.M., Croucher Senior Medical Fellowship, The Croucher Foundation. 2008.

Nicholls J.M., Peiris J.S.M. and Guan Y., Sialic acid and receptor expression on the respiratory tract in normal subjects and H5N1 and non-avian influenza patients, Hong Kong Medical Journal. 2009, 15(3 Suppl 4): 16-20.

Nicholls J.M., Chan M.C.W., Chan W.Y., Peiris J.S.M., Malakhov M., Li H., Huang Y., Zaltash S., Hawley S., Haslam S., Karamanska R. and Fang F., The use of sialidase treatment in influenza virus infection , XI International Symposium on Respiratory Viral Infections. 2009.

Nicholls J.M. and Peiris J.S.M., Use of DAS181 as a potential therapy for influenza, Sialyoglycobiology 2008, Moscow . 2008.

Peiris J.S.M., Poon L.L.M., Nicholls J.M. and Guan Y., The role of influenza virus gene constellation and viral morphology on cytokine induction, pathogenesis, and viral virulence, Hong Kong Medical Journal. 2009, 15(3 Suppl 4): 21-3.

Poon L.L.M., Leung C.Y.H., Nicholls J.M., Lichy J.H., Yamamoto M., Waldmann T.A., Peiris J.S.M. and Perera L.P., Vaccinia virus-based multivalent H5N1 avian influenza vaccines adjuvanted with IL-15 confer sterile cross-clade protection in mice, The Jounal of Immunology. 2009, 182(5): 3063-71.

Siu Y.L., Teoh K.T., Lo J.C.Y., Chan C.M., Kien F.S., Escriou N., Tsao G.S.W., Nicholls J.M., Altmeyer R.M., Peiris J.S.M., Bruzzone R. and Nal-Rogier B.T.M., The M, E and N structural proteins of the SARS coronavirus are required for efficient assembly, trafficking and release of virus-like particles., Journal of Virology. 2008.

Siu Y.L., Teoh K.T., Lo J.C.Y., Chan C.M., Kien F.S., Escriou N., Tsao G.S.W., Nicholls J.M., Altmeyer R.M., Peiris J.S.M., Bruzzone R. and Nal-Rogier B.T.M., The M, E, And N Structural Proteins Of The Severe Acute Respiratory Syndrome Coronavirus Are Required For Efficient Assembly, Trafficking, And Release Of Virus-like Particles., Journal of Virology. 2008, 82(22): 11318-30.

Tse H.F., Liao S., Siu D.C.W., Liu Y., Nicholls J.M., Leung G., Ormsby T., Feld G.K. and Lau C.P., Determinants of lesion dimensions during transcatheter microwave ablation, Pacing Clin Electrophysiol. . 2009, 32(2): 201-8.

Wu Y., Chan W.S., Nicholls J.M., Liao S., Tse H.F. and Wu E.X., MR study of the effect of infarct size and location on left ventricular functional and microstructural alterations in porcine models, Journal of Magnetic Resonance Imaging. 2009, 29(2): 305-12.

Zhu J.Y., Pfuhl T., Motsch N., Barth S., Nicholls J.M., Grasser F. and Meister G., Identification of novel Epstein-Barr virus microRNA genes from nasopharyngeal carcinomas, Journal of Virology. 2009, 83(7): 3333-41.

Researcher : Shen L

List of Research Outputs

Iqbal J., Kucuk C., Deleeuw R.J., Srivastava G., Tam W., Geng H., Klinkebiel D., Christman J.K., Patel K., Cao K., Shen L., Dybkaer K., Tsui I.F., Ali H., Shimizu N., Au W.Y., Lam W.L. and Chan W.C., Genomic analyses reveal global functional alterations that promote tumor growth and novel tumor suppressor genes in natural killer-cell malignancies, Leukemia. 2009, Epub 2009 Feb 5.

Shen L., Au W.Y., Wong K.Y., Shimizu N., Tsuchiyama J., Kwong Y.L., Liang R.H.S. and Srivastava G., Cell death by bortezomib-induced mitotic catastrophe in natural killer lymphoma cells, Molecular Cancer Therapeutics. 2008, 7(12): 3807-15.

Researcher : Sin SL

List of Research Outputs

Lee K.W., Castilho A.G., Sin S.L., Ma S.K.Y. and Ng I.O.L., The specific targeting of liver cancer stem cells by lupeol through PTEN modulation, American Association for Cancer Research. 2009.

Researcher : Siu KY

List of Research Outputs

Au C.W.H., Siu K.Y., Liao X., Wong E.S.Y., Ngan H.Y.S., Tam K.F., Chan D.C.W., Chan Q.K.Y. and Cheung A.N.Y., Tyrosine kinase B receptor and BDNF expression in ovarian cancers - Effect on cell migration, angiogenesis and clinical outcome, Cancer Letters. 2009, 281: 151-161.

Chan H.Y., Siu K.Y., Zhang H., Wong E.S.Y., Ngan H.Y.S., Chan K.Y.Q. and Cheung A.N.Y., Activated Stat3 expression in gestational trophoblastic disease: correlation with clinicopathological parameters and apoptotic indices, Histopathology. 2008, 53(2): 139-146.

Cheung A.N.Y., Zhang H., Xue W. and Siu K.Y., Pathogenesis of choriocarcinoma: clinical, genetic and stem cell perspectives, Future Oncology. 2009, 5(2): 217-231.

Kong S.H., Siu K.Y., Chan H.Y., Jiang L., Tam K.F., Ngan H.Y.S., Le X.F. and Cheung A.N.Y., Overexpression of αPIX contributes to ovarian cancer metastasis, increased chemoresistance and poor prognosis., The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18 - 22 April 2009.. 2009.

Liao X., Siu K.Y., Au W.H., Chan K.Y.Q., Chan H.Y., Wong E.S.Y., Ip P.P.C., Ngan H.Y.S. and Cheung A.N.Y., Aberrant activation of hedgehog signaling pathway contributes to endometrial carcinogenesis through β-catenin., Modern Pathol.. 2009, 22: 839-847.

Liao X., Siu K.Y., Au W.H., Wong E.S.Y., Chan H.Y., Ip P.P.C., Ngan H.Y.S. and Cheung A.N.Y., Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation., Carcinogenesis. 2009, 30: 131-140.

Liao X., Siu K.Y., Wong E.S.Y., Ngan H.Y.S., Chan K.Y.Q., Li A.S.M., Khoo U.S. and Cheung A.N.Y., Hypermethylation of RAS effector related genes and DNA methyltransferase 1 expression in endometrial carcinogenesis, Int J Cancer. 2008, 123(2): 296-302.

Liao X., Chan Y.K., Chan I.L.S., Wong K.Y., Wong E.S.Y., Chan H.Y., Siu K.Y., Khoo U.S., Ngan H.Y.S. and Cheung A.N.Y., Kinesin family member 7 (KIF7) in endometrial and ovarian cancers , The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18 - 22 April 2009. . 2009.

Siu K.Y., Wong E.S.Y., Chan H.Y., Ngan H.Y.S., Chan Y.K. and Cheung A.N.Y., Overexpression of NANOG in Gestational Trophoblastic Diseases. Effect on Apoptosis, Cell Invasion, and Clinical Outcome, Am J Pathol. 2008, [Epub ahead of print].

Zhang H., Siu K.Y., Wong E.S.Y., Chan H.Y., Ngan H.Y.S. and Cheung A.N.Y., Activation of PKB/AKT promotes cell survival and invasion in choriocarcinoma, The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18 - 22 April 2009.. 2009.

Zhang H., Xue W.C., Siu K.Y., Liao X., Ngan H.Y.S. and Cheung A.N.Y., P63 Expression in Gestational Trophoblastic Disease: Correlation With Proliferation and Apoptotic Dynamics., Int. J. Gynecol. Pathol. . 2009, 28: 172-178.

Zhao F., Siu K.Y., Wong E.S.Y., Chan H.Y., Jiang L., Ngan H.Y.S. and Cheung A.N.Y., Overexpression of Dock180 in ovarian cancer, The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18 - 22 April 2009.. 2009.

Researcher : So JCC

List of Research Outputs

Au W.Y., Wong K.Y., Wan T.S.K., So J.C.C., Srivastava G. and Liang R.H.S., A unique case of B cell lymphoma relapsing as CD4/CD56 blastic neoplasm, Leuk Lymphoma . 2009, 50(6): 932-6.

Au W.Y., Ha S.Y., Wan T.S.K., So J.C.C. and Wong K.F., A unique case of familial leukaemia: maternal puerperal leukaemia followed by infantile leukaemia with monosomy 7, Br J Haematol. 2008, 143(3): 445-6.

Au W.Y., So J.C.C., Ma E.S.K. and Lie A.K.W., Glucose-6-phosphate-dehydrogenase deficiency and haematopoietic stem cell transplantation in Chinese patients, Hong Kong Med J . 2009, 15(3 Suppl 3): 35-8.

Au W.Y., Tse J., So J.C.C., Wan T.S.K. and Young K., Unexpected glucose-6-phosphate dehydrogenase deficiency, Br J Haematol. 2008, [Epub ahead of print].

Gibney G.T., Panhuysen C.I.M., So J.C.C., Ma E.S.K., Ha S.Y., Li C.K., Lee A.C.W., Li C.K., Yuen H.L., Lau Y.L., Johnson D.M., Farrell J.J., Bisbee A.B., Farrer L.A., Steinberg M.H., Chan L.C. and Chui D.H.K., Variation and heritability of Hb F and F-cells among b-thalassemia heterozygotes in Hong Kong, American Journal of Hematology. 2008, 83(6): 458-464.

Hwang Y.Y., Tse E.W.C., So J.C.C., Wan T.S.K. and Kwong Y.L., Persistent neutropenia in chronic myelogenous leukemia in chronic phase treated with imatinib mesylate, American Journal of Hematology. 2009, 84(5): 302-5.

Sedgewick A.E., Timofeev N., Sebastiani P., So J.C.C., Ma E.S.K., Chan L.C., Fucharoen G., Fucharoen S., Barbosa C.G., Vardarajan B.N., Farrer L.A., Baldwin C.T., Steinberg M.H. and Chui D.H.K., BCL11A is a major HbF quantitative trait locus in three different populations with beta-hemoglobinopathies, Blood Cells Mol Dis. 2008, 41(3): 255-8.

So J.C.C., Wan T.S.K., Ma E.S.K. and Chan L.C., An unbalanced translocation, der(17)t(1;17)(p13;p11.2), leads to heterozygous loss of TP53 and is associated with clinical evolution in myelodysplastic syndrome, Br J Biomed Sci. 2008, 65(1): 36-38.

So J.C.C., Beyond clots: Molecular studies for coagulation, University of Hong Kong & Royal Free Hospital Coagulation Workshop 2008. 2008.

So J.C.C., Genetic characterization of hereditary red cell disorders and building a Chinese database, Monthly scientific meeting of The Hong Kong Paediatric Haematology and Oncology Study Group. 2008.

So J.C.C., Genetic diagnosis of thalassaemia in Chinese, The Ninth Chinese Laboratory Medicine Conference, Hong Kong. 2009.

So J.C.C., Genetic study of thalassaemia: The Hong Kong scenario, Thalassaemia Forum at Department of Paediatrics, Hospital Centre of CSJ, Macau. 2009.

So J.C.C., Genetic study of thalassaemia: The Hong Kong scenario, Thalassaemia Forum of The Hong Kong Society for the Study of Thalassaemia . 2009.

So J.C.C., Leung R.Y.Y., Yip S.F., Lam C.C.K. and Chan L.C., Invasive Streptococcus pneumoniae infection associated with hemolytic uremic syndrome in Chinese pediatric patients. , 50th American Society of Hematology Annual Meeting and Expositions, USA. 2008.

So J.C.C., Laboratory investigations in haemoglobinopathies, Haematopathology Morphology Workshop The Malaysian Society of Haematology & Department of Hematology, Hospital Ampang, Malaysia. 2008.

So J.C.C., Song Y., Tsang S.T.Y., Tang L.F., Chan A.Y.W., Ma E.S.K. and Chan L.C., The HBS1L-MYB intergenic region on chromosome 6q23 is a quantitative trait locus controlling fetal haemoglobin level in carries of β-thalassaemia, J Med Gen. 2008, 45(11): 745-51.

Sun Q., So J.C.C., Yip S.F., Wan T.S.K., Ma E.S.K. and Chan L.C., Functional alterations of Lin-CD34+CD38+ cells in chronic myelomonocytic leukemia and on progression to acute leukemia, Leuk Res. 2008, 32(9): 1374-1381.

Researcher : So KT

List of Research Outputs

So K.T., Tam I.Y., Leung L.H., Tin P.C., Wong W.S., Sihoe A.D.L., Cheng L.C., Chung L.P. and Wong M.P., Mutational analysis of EGFR-related genes in non-small cell lung cancer (Poster), American Association for Cancer Research Annual Meeting, 2009 April 18-22, 2009, Denver, Colorado, the United State . 2009.

Wong W.S., Leung L.H., So K.T., Tam Y.S.I., Sihoe A.D.L., Cheng L.C., Ho K.K., Au J.S., Chung L.P. and Wong M.P., The Eml4-alk Fusion Gene Is Involved In Various Histologic Types Of Lung Cancers From Nonsmokers With Wild-type Egfr And Kras, Cancer. 2009, 115: 1723-1733.

Researcher : Srivastava G

List of Research Outputs

Au W.Y., Wong K.Y., Wan T.S.K., So J.C.C., Srivastava G. and Liang R.H.S., A unique case of B cell lymphoma relapsing as CD4/CD56 blastic neoplasm, Leuk Lymphoma . 2009, 50(6): 932-6.

Chan K.K. and Srivastava G., The Anti-Tumor Effect Of An Anti-CD25 mAb On Nasal NK Cell Lymphoma, Abstract of the 12th Research Postgraduate Symposium HKU, LKS Faculty of Medicine. 2008.

Cui Y., Ying Y., van Hasselt A., Ng K.M., Yu J., Zhang Q., Jin J., Liu D., Rhim J.S., Rha S.Y., Loyo M., Chan A.T., Srivastava G., Tsao G.S.W., Sellar G.C., Sung J.J., Sidransky D. and Tao Q., OPCML is a broad tumor suppressor for multiple carcinomas and lymphomas with frequently epigenetic inactivation, PLoS ONE. 2008, 3(8): e2990.

Dong G., Chanudet E., Hamoudi R.A., Chen W.Y.W., Chuang S.S., Ye H., Liu H., Gao Z., Srivastava G. and Du M.Q., Genomic Profiles of Gastrointestinal Diffuse Large B-cell Lymphoma, The Journal of Pathology. 2009, 219: S5.

Fu L., Gao Z., Zhang X., Tsang Y.H., Goh H.K., Geng H., Shimizu N., Tsuchiyama J., Srivastava G. and Tao Q., Frequent concomitant epigenetic silencing of the stress-responsive tumor suppressor gene CADM1, and its interacting partner DAL-1 in nasal NK/T-cell lymphoma, Int J Cancer. 2008, 124(7): 1572-1578.

Hwang Y.Y., Wong K.Y., Leung R.Y.Y., Wong S.H., Chan S.C., Srivastava G. and Au W.Y., Post-rituximab Burkitt transformation of PTLD: loss of CD20 expression accompanied by a switch in light-chain expression, Ann Hematol. 2009, [Epub ahead of print].

Iqbal J., Kucuk C., Deleeuw R.J., Srivastava G., Tam W., Geng H., Klinkebiel D., Christman J.K., Patel K., Cao K., Shen L., Dybkaer K., Tsui I.F., Ali H., Shimizu N., Au W.Y., Lam W.L. and Chan W.C., Genomic analyses reveal global functional alterations that promote tumor growth and novel tumor suppressor genes in natural killer-cell malignancies, Leukemia. 2009, Epub 2009 Feb 5.

Jacobs C.L., Lagoo A.S., Dash R.C., Raji A., Evens A.M., Winter J.N., Gordon L.I., Kahl B.S., Czader M., Srivastava G., Mann K.P., Gill J., Rizzieri D. and Dave S., MicroRNAs Distinguish Burkitt Lymphoma from the Molecular Subsets of Diffuse Large B Cell Lymphoma, Blood. 2008, 112(11): 1151.

Kucuk C., Iqbal J., Deleeuw R.J., Srivastava G., Tam W., Klinkebiel D., Christman J.K., Dybkaer K., Au W.Y., Lam W.L. and Chan W.C., Genomic Analyses Reveal Global Functional Alterations That Promote Tumor Growth and Novel Tumor Suppressor Genes in Natural Killer-Cell Malignancies, Blood. 2008, 112(11): 1298.

Lee K.Y., Geng H., Ng K.M., Yu J., van Hasselt A., Cao Y., Zeng Y.X., Wong A.H., Wang X., Ying J., Srivastava G., Lung M.L., Wang L.D., Kwok T.T., Levi B.Z., Chan A.T., Sung J.J. and Tao Q., Epigenetic disruption of interferon-gamma response through silencing the tumor suppressor interferon regulatory factor 8 in nasopharyngeal, esophageal and multiple other carcinomas, Oncogene. 2008, 27(39): 5267-5276.

Liu X., Wu W.K., Yu L., Sung J.J., Srivastava G., Zhang S.T. and Cho C.H., Epinephrine stimulates esophageal squamous-cell carcinoma cell proliferation via beta-adrenoceptor-dependent transactivation of extracellular signal-regulated kinase/cyclooxygenase-2 pathway, J Cell Biochem. 2008, 105(1): 53-60.

Shen L., Au W.Y., Wong K.Y., Shimizu N., Tsuchiyama J., Kwong Y.L., Liang R.H.S. and Srivastava G., Cell death by bortezomib-induced mitotic catastrophe in natural killer lymphoma cells, Molecular Cancer Therapeutics. 2008, 7(12): 3807-15.

Srivastava G., Editor & Editorial Board Member of International Journal of Medical Sciences. 2008.

Wang Y., Li J., Cui Y., Li T., Ng K.M., Geng H., Li H., Shu X.S., Li H., Liu W., Luo B., Zhang Q., Mok T.S., Zheng W., Qiu X., Srivastava G., Yu J., Sung J.J., Chan A.T., Ma D., Tao Q. and Han W., CMTM3, located at the critical tumor suppressor locus 16q22.1, is silenced by CpG methylation in carcinomas and inhibits tumor cell growth through inducing apoptosis, Cancer Res. 2009, 69(12): 5194-201.

Wong V.C.L., Chan P.L., Bernabeu C., Law S.Y.K., Wang L.D., Li J.L., Tsao G.S.W., Srivastava G. and Lung M.L., Identification of an invasion and tumor-suppressing gene, Endoglin (ENG), silenced by both epigenetic inactivation and allelic loss in esophageal squamous cell carcinoma, International Journal of Cancer. 2008, 123(12): 2816-2823.

Yuen H.F., Chan Y.P., Law S.Y.K., Srivastava G., E1-tanani M., Mak T.W. and Chan K.W., DJ-1 could predict worse prognosis in esophageal squamous cell carcinoma, Cancer Epidemiology, Biomarkers & Prevention. 2008, 17(12): 3593-3602.

Researcher : Sun Q

List of Research Outputs

Sun Q., So J.C.C., Yip S.F., Wan T.S.K., Ma E.S.K. and Chan L.C., Functional alterations of Lin-CD34+CD38+ cells in chronic myelomonocytic leukemia and on progression to acute leukemia, Leuk Res. 2008, 32(9): 1374-1381.

Researcher : Sze MF

List of Research Outputs

Sze M.F., Ching Y.P., Jin D. and Ng I.O.L., Role of a novel splice variant of mitotic arrest deficient 1 (MAD1), MAD1beta, in mitotic checkpoint control in liver cancer, In: American Association for Cancer Research, Cancer Research. 2008, 68: 9194-9201.

Researcher : Tam KY

List of Research Outputs

Fan P.Y.S., Lui P.C., Tam K.Y., Hung K.N., Ng H.K. and Leung S.Y., A 33-year-old Chinese woman with a left frontal tumor, Brain Pathol.. 2009, 19(2): 337-40.

Researcher : Tam S

List of Research Outputs

Au W.Y., Tam S., Fong B.M. and Kwong Y.L., Determinants of cerebrospinal fluid arsenic concentration in patients with acute promyelocytic leukemia on oral arsenic trioxide therapy, Blood. 2008, 112(9): 3587-3590.

Au W.Y., Tam S., Fong B.M. and Kwong Y.L., Oral arsenic treatment of leukemia and the risk of porphyria, Leukaemia Research . 2009, 33(4): 598-600.

Lam C.M., Lam B., Yao T.J., Lai A.Y.K., Ooi C.G.C., Tam S., Lam K.S.L. and Ip M.S.M., A double-blind randomized controlled study of nasal continuous positive airway pressure treatment on insulin sensitivity in men with obstructive sleep apnea., 13th Congress of the Asian Pacific Society of Respirology, Bangkok, Thailand. Respirology.. 2008, 13 (Supp 5): A135 (O20-03).

Lam C.W., Lan L.C.L., Che C.M., Tam S., Wong S.S.Y., Chen Y., Jin J., Tao S.H., Tang X.M., Yuen K.Y. and Tam P.K.H., Diagnosis and spectrum of melamine-related renal disease: plausible mechanism of stone formation in humans, Clinica Chimica Acta. 2009, 402: 150-155.

Lam M.F., Leung J.C.K., Lam C.W., Tse K.C., Lo W.K., Lui S.L., Chan D.T.M., Tam S. and Lai K.N., Procalcitonin fails to differentiate inflammatory status or predict long-term outcomes in peritoneal dialysis-associated peritonitis, Peritoneal Dialysis International. 2008, 28: 377-84.

Lui S.L., Tsang R.C.W., Chan K.W., Zhang Q., Tam S., Yung S.S.Y. and Chan D.T.M., Rapamycin attenuates the severity of murine adriamycin nephropathy [Epub 27Aug 2008], American Journal of Nephropathy. 2008, 29: 342-352.

Wong C.Y., Qiuwaxi J., Chen H., Li S.W., Chan H.T., Tam S., Shu X.O., Lau C.P., Kwong Y.L. and Tse H.F., Daily intake of thiamine correlates with the circulating level of endothelial progenitor cells and the endothelial function in patients with type II diabetes, Molecular Nutrition & Food Research. online, 2008, 52 (12): 1421 - 1427.

Researcher : Tam YSI

List of Research Outputs

Tam Y.S.I., Epidermal Growth Factor Receptor (EGFR) Mutations and Phosphorylation Pattern in Non-Small Cell Lung Ccancer (NSCLC), 2008.

Wong W.S., Leung L.H., So K.T., Tam Y.S.I., Sihoe A.D.L., Cheng L.C., Ho K.K., Au J.S., Chung L.P. and Wong M.P., The Eml4-alk Fusion Gene Is Involved In Various Histologic Types Of Lung Cancers From Nonsmokers With Wild-type Egfr And Kras, Cancer. 2009, 115: 1723-1733.

Researcher : Tang JCO

List of Research Outputs

Pak K.C., Lam A.K.Y., Law S.Y.K. and Tang J.C.O., The inhibitory effect of Gleditsia sinensis on cyclooxygenase-2 expression in human esophageal squamous cell carcinoma, International Journal of Molecular Medicine. 2009, 23(1): 121-129.

Researcher : Tang KH

List of Research Outputs

Ma S.K.Y., Chan K.W., Lee K.W., Tang K.H., Wo Y.H., Zheng B. and Guan X.Y., Aldehyde dehydrogenase discriminates the CD133 liver cancer stem cell populations, Molecular Cancer Research. 2008, 6: 1146-1153.

Ma S.K.Y., Chan Y.P., Lee K.W., Tang K.H., Ng I.O.L., Man K., To K.F., Zheng B., Chan K.W. and Guan X.Y., The role of miR-130b in the regulation of CD133+ cancer stem cells-driven hepatocellular carcinoma, The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18-22 April 2009.

Tang K.H., Ma S.K.Y., Lee K.W., Ng I.O.L., Man K., To K.F., Zheng B., Guan X.Y. and Chan K.W., CD133+ liver cancer stem cells promote tumor growth and angiogenesis through increased interleukin-8 secretion, The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18-22 April 2009.

Researcher : Tao Q

List of Research Outputs

Cui Y., Ying Y., van Hasselt A., Ng K.M., Yu J., Zhang Q., Jin J., Liu D., Rhim J.S., Rha S.Y., Loyo M., Chan A.T., Srivastava G., Tsao G.S.W., Sellar G.C., Sung J.J., Sidransky D. and Tao Q., OPCML is a broad tumor suppressor for multiple carcinomas and lymphomas with frequently epigenetic inactivation, PLoS ONE. 2008, 3(8): e2990.

Fu L., Gao Z., Zhang X., Tsang Y.H., Goh H.K., Geng H., Shimizu N., Tsuchiyama J., Srivastava G. and Tao Q., Frequent concomitant epigenetic silencing of the stress-responsive tumor suppressor gene CADM1, and its interacting partner DAL-1 in nasal NK/T-cell lymphoma, Int J Cancer. 2008, 124(7): 1572-1578.

Lee K.Y., Geng H., Ng K.M., Yu J., van Hasselt A., Cao Y., Zeng Y.X., Wong A.H., Wang X., Ying J., Srivastava G., Lung M.L., Wang L.D., Kwok T.T., Levi B.Z., Chan A.T., Sung J.J. and Tao Q., Epigenetic disruption of interferon-gamma response through silencing the tumor suppressor interferon regulatory factor 8 in nasopharyngeal, esophageal and multiple other carcinomas, Oncogene. 2008, 27(39): 5267-5276.

Wang Y., Li J., Cui Y., Li T., Ng K.M., Geng H., Li H., Shu X.S., Li H., Liu W., Luo B., Zhang Q., Mok T.S., Zheng W., Qiu X., Srivastava G., Yu J., Sung J.J., Chan A.T., Ma D., Tao Q. and Han W., CMTM3, located at the critical tumor suppressor locus 16q22.1, is silenced by CpG methylation in carcinomas and inhibits tumor cell growth through inducing apoptosis, Cancer Res. 2009, 69(12): 5194-201.

Researcher : Tin PC

List of Research Outputs

Leung L.H., Tam I.Y., Tin P.C., Chua D.T.T., Sihoe A.D.L., Cheung L.C., Ho J.C.M., Chung L.P. and Wong M.P., Src Promotes Survival and Invasion of Lung Cancers with Epidermal Growth Factor Receptor Abnormalities and Is a Potential Candidate for Molecular-Targeted Therapy., Molecular Cancer Research. 2009, 7(6): 923-32.

So K.T., Tam I.Y., Leung L.H., Tin P.C., Wong W.S., Sihoe A.D.L., Cheng L.C., Chung L.P. and Wong M.P., Mutational analysis of EGFR-related genes in non-small cell lung cancer (Poster), American Association for Cancer Research Annual Meeting, 2009 April 18-22, 2009, Denver, Colorado, the United State . 2009.

Tam I.Y., Leung L.H., Tin P.C., Chua D.T.T., Sihoe A.D.L., Cheng L.C., Chung L.P. and Wong M.P., EGFR mutants containing rare EGFR mutant types show reduced response to in-vitro gefitinib compared to common activating missense mutations (Poster), American Association for Cancer Research Annual Meeting, 2009 April 18-22, 2009, Denver, Colorado, the United State . 2009.

Wong W.S., Leung L.H., Tin P.C., Sihoe A.D.L., Cheng L.C., Chung L.P. and Wong M.P., ALK kinase domain is aberrantly expressed but not mutated in Chinese non-small cell lung cancer from male smokers with squamous cell carcinoma (Poster), American Association for Cancer Research Annual Meeting, 2009 April 18-22, 2009, Denver, Colorado, the United State . 2009.

Researcher : Ting KP

List of Research Outputs

Ting K.P., Wu L.H., Ip Y.C., Khoo U.S. and Chan Y.K., Mini-chromosome-maintenance-deficient 4 (MCM4) in breast cancer and its clinical significance (Oral presentation), The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18 - 22 April 2009. . 2009.

Researcher : Trendell-Smith NJ

List of Research Outputs

Chung H.Y., Trendell-Smith N.J., Yeung C.K. and Mok T.M.Y., Dego’s disease – a rare condition simulating rheumatic diseases [Epub Mar 20], Clinical Rheumatology. 2009, 28(7): 861-863.

Yeung C.K., Trendell-Smith N.J., Mak H.K.F., Lam C.C.K. and Kwong Y.L., Cutaneous intravascular large B-cell lymphoma: Asian variant or not? , Clinical and Experimental Dermatology (2009, in press).. 2009.

Yuen P.W., Kwong D.L.W., Leung G.K.K., Lee R. and Trendell-Smith N.J., Minimally invasive endoscopic surgery of anterior skull base, Hong Kong Academy of Medicine 15th Anniversary Congress entitled "Working together - the power of collaboration". 2008.

Yuen P.W., Ho C.M., Chow T.L., Tang L.C., Cheung W.Y., Ng W.M., Wei W.I., Kong C.K., Book K.S., Yuen W.C., Lam A.K., Yuen N.W., Trendell-Smith N.J., Chan Y.W., Wong B.Y.H., Li G.K.H., Ho A.C.W., Ho W.K., Wong S.Y. and Yao T.J., Prospective randomized study of selective neck dissection versus observation for N0 neck of early tongue carcinoma, Head and Neck. 2009, 31: 765-772.

Researcher : Tsang STY

List of Research Outputs

So J.C.C., Song Y., Tsang S.T.Y., Tang L.F., Chan A.Y.W., Ma E.S.K. and Chan L.C., The HBS1L-MYB intergenic region on chromosome 6q23 is a quantitative trait locus controlling fetal haemoglobin level in carries of β-thalassaemia, J Med Gen. 2008, 45(11): 745-51.

Researcher : Tse YT

List of Research Outputs

Tse Y.T. and Yam J.W.P., Role of caveolin-1 in hepatocellular carcinoma carcinogenesis and metastasis, 15th Hong Kong International Cancer Congress and 5th Annual Meeting Centre for Cancer Research, Hong Kong.. 2008, Abstract No. A25.

Tse Y.T., Ko F.C.F., Lee K.W., Ngan E.S.W., Ng I.O.L. and Yam J.W.P., Upregulation of caveolin-1 in human hepatocellular carcinoma, American Association for Cancer Research 100th Annual Meeting, Denver, Colorado, USA, 2009.

Yam J.W.P., Tse Y.T. and Ng I.O.L., Role and significance of focal adhesion proteins in hepatocellular carcinoma, J Gastroenterol Hepatol. 2009, 24: 520-530.

Researcher : Tsui WY

List of Research Outputs

Chan T.L., Yuen S.T., Kuiper R.P., Lee T.Y.H., Tsui W.Y., Lau J.K.Y., Li C., Chan K.W., Kong C.K., Chan A.S.Y., Ligtenberg M.J.L. and Leung S.Y., Deletion of the 3’ Exons of TACSTD1 Causes Hereditary Nonpolyposis Colorectal Cancer with MSH2 Gene Promoter Methylation, The 3rd Biennial Meeting of The International Society for Gastrointestinal Hereditary Tumours (InSiGHT), Dusseldorf, Germany. 2009.

Ligtenberg M.J., Kuiper R.P., Chan T.L., Goossens M., Hebeda K.M., Voorendt M., Lee T.Y.H., Bodmer D., Hoenselaar E., Hendriks-Cornelissen S.J., Tsui W.Y., Kong C.K., Brunner H.G., van Kessel A.G., Yuen S.T., van Krieken J.H., Leung S.Y. and Hoogerbrugge N., Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3' exons of TACSTD1, Nat Genet. 2009, 41(1): 112-7.

Researcher : Tung KK

List of Research Outputs

Tung K.K., Wong C.M., Yau T.O., Lee M.F., Ching Y.P. and Ng I.O.L., HAI-2 is epigenetically downregulated in human hepatocellular carcinoma, and its Kunitz domain type 1 is critical for anti-invasive functions. , International Journal of Cancer. 2009, 124: 1811.

Wong C.L., Wong C.M., Tung K.K., Man K. and Ng I.O.L., Rho-kinase 2 is frequently overexpressed in hepatocellular carcinoma and involved in tumor invasion., Hepatology. 2009, 49 (5): 1583-1594.

Researcher : Wan TSK

List of Research Outputs

Au W.Y., Wong K.Y., Wan T.S.K., So J.C.C., Srivastava G. and Liang R.H.S., A unique case of B cell lymphoma relapsing as CD4/CD56 blastic neoplasm, Leuk Lymphoma . 2009, 50(6): 932-6.

Au W.Y., Ha S.Y., Wan T.S.K., So J.C.C. and Wong K.F., A unique case of familial leukaemia: maternal puerperal leukaemia followed by infantile leukaemia with monosomy 7, Br J Haematol. 2008, 143(3): 445-6.

Au W.Y., Tse J., So J.C.C., Wan T.S.K. and Young K., Unexpected glucose-6-phosphate dehydrogenase deficiency, Br J Haematol. 2008, [Epub ahead of print].

Hwang Y.Y., Tse E.W.C., So J.C.C., Wan T.S.K. and Kwong Y.L., Persistent neutropenia in chronic myelogenous leukemia in chronic phase treated with imatinib mesylate, American Journal of Hematology. 2009, 84(5): 302-5.

So J.C.C., Wan T.S.K., Ma E.S.K. and Chan L.C., An unbalanced translocation, der(17)t(1;17)(p13;p11.2), leads to heterozygous loss of TP53 and is associated with clinical evolution in myelodysplastic syndrome, Br J Biomed Sci. 2008, 65(1): 36-38.

Sun Q., So J.C.C., Yip S.F., Wan T.S.K., Ma E.S.K. and Chan L.C., Functional alterations of Lin-CD34+CD38+ cells in chronic myelomonocytic leukemia and on progression to acute leukemia, Leuk Res. 2008, 32(9): 1374-1381.

Researcher : Wong CCL

List of Research Outputs

Wong C.C.L., Wong C.M., Ko F.C.F., Chan L.K., Ching Y.P., Yam J.W.P. and Ng I.O.L., Deleted in liver cancer 1 (DLC1) negatively regulates Rho/ROCK/MLC pathway in hepatocellular carcinoma, PLoS One. 2008, 3: e2779.

Researcher : Wong CL

List of Research Outputs

Au L.K., Wong C.L., Lee M.F., Wong C.M. and Ng I.O.L., Overexpression of the histone methyltransferase Enhancer of Zeste Homolog 2 was involved in multistep hepatocarcinogenesis and metastasis of hepatocellular carcinoma, American Association for Cancer Research 100th Annual Meeting. Denvoer, CO, USA, 2009.

Wong C.L., Wong C.M., Tung K.K., Man K. and Ng I.O.L., Rho-kinase 2 is frequently overexpressed in hepatocellular carcinoma and involved in tumor invasion., Hepatology. 2009, 49 (5): 1583-1594.

Researcher : Wong CM

List of Research Outputs

Au L.K., Wong C.M. and Ng I.O.L., Deregulation of Enhancer of Zeste Homolog 2 (EZH2) in Hepatocellular Carcinoma (HCC), 15th Hong Kong International Cancer Congress. 2008.

Au L.K., Wong C.L., Lee M.F., Wong C.M. and Ng I.O.L., Overexpression of the histone methyltransferase Enhancer of Zeste Homolog 2 was involved in multistep hepatocarcinogenesis and metastasis of hepatocellular carcinoma, American Association for Cancer Research 100th Annual Meeting. Denvoer, CO, USA, 2009.

Lee M.F., Wong C.M. and Ng I.O.L., Hepatitis B virus-associated multistep hepatocarcinogenesis: a stepwise increase in allelic alterations, In: Cancer Research, 2008, 68 (14): 5988-5996.

Tung K.K., Wong C.M., Yau T.O., Lee M.F., Ching Y.P. and Ng I.O.L., HAI-2 is epigenetically downregulated in human hepatocellular carcinoma, and its Kunitz domain type 1 is critical for anti-invasive functions. , International Journal of Cancer. 2009, 124: 1811.

Wong C.C.L., Wong C.M., Ko F.C.F., Chan L.K., Ching Y.P., Yam J.W.P. and Ng I.O.L., Deleted in liver cancer 1 (DLC1) negatively regulates Rho/ROCK/MLC pathway in hepatocellular carcinoma, PLoS One. 2008, 3: e2779.

Wong C.L., Wong C.M., Tung E.K., Lee M.F., Man K. and Ng I.O.L., Rho-kinase 2 (ROCK2) is involved in hepatocellular carcinoma progression, metastasis and invasion, Second Annual Meeting, International Liver Cancer Association, Chicago, USA. 2008.

Wong C.L., Wong C.M., Tung K.K., Man K. and Ng I.O.L., Rho-kinase 2 is frequently overexpressed in hepatocellular carcinoma and involved in tumor invasion., Hepatology. 2009, 49 (5): 1583-1594.

Wong C.M., Cancer Epigenetics: the roles of aberrant DNA methylation and histone modifications in cancer development, 15th Hong Kong International Cancer Congress. 2008.

Wong C.M., Epigenetic alterations and liver carcinogenesis, Shanghai Cancer Institute, Shanghai, China. 2008.

Wong C.M., Epigenetic alterations in liver cancer, Institute of Biochemistry and Cell Biology, SIBS, Chinese Academy of Sciences, Shanghai, China. . 2008.

Wong C.M. and Ng I.O.L., Overexpression of histone methyltransferases SUV39H1 and SUV39H2 in hepatocellular carcinoma, American Association for Cancer Research 100th Annual Meeting. Denver, CO, USA, 2009.

Zhang X.N., Wong C.M., Huang P.C. and Huang W.L., Tumor suppressor deleted in liver cancer-1 (DLC-1) gene triggers apoptosis in NPC cells by perturbing mitochondria (MI), The 13th Biennial Conference of the International Association for Research on Epstein-Barr Virus and Associated Diseases, Guangzhou, China. 2008.

Researcher : Wong ESY

List of Research Outputs

Au C.W.H., Siu K.Y., Liao X., Wong E.S.Y., Ngan H.Y.S., Tam K.F., Chan D.C.W., Chan Q.K.Y. and Cheung A.N.Y., Tyrosine kinase B receptor and BDNF expression in ovarian cancers - Effect on cell migration, angiogenesis and clinical outcome, Cancer Letters. 2009, 281: 151-161.

Chan H.Y., Siu K.Y., Zhang H., Wong E.S.Y., Ngan H.Y.S., Chan K.Y.Q. and Cheung A.N.Y., Activated Stat3 expression in gestational trophoblastic disease: correlation with clinicopathological parameters and apoptotic indices, Histopathology. 2008, 53(2): 139-146.

Deng W., Tsao G.S.W., Kwok K.Y., Wong E.S.Y., Huang X.R., Liu S., Tsang C.M., Ngan H.Y.S., Cheung A.N.Y., Lan H.Y., Guan X.Y. and Cheung A., Transforming growth factor b1 promotes chromosomal instability in human papillomavirus 16 E6E7-infected cervical epithelial cells, Cancer Research. 2008, 68: 7200-7209.

Liao X., Siu K.Y., Au W.H., Chan K.Y.Q., Chan H.Y., Wong E.S.Y., Ip P.P.C., Ngan H.Y.S. and Cheung A.N.Y., Aberrant activation of hedgehog signaling pathway contributes to endometrial carcinogenesis through β-catenin., Modern Pathol.. 2009, 22: 839-847.

Liao X., Siu K.Y., Au W.H., Wong E.S.Y., Chan H.Y., Ip P.P.C., Ngan H.Y.S. and Cheung A.N.Y., Aberrant activation of hedgehog signaling pathway in ovarian cancers: effect on prognosis, cell invasion and differentiation., Carcinogenesis. 2009, 30: 131-140.

Liao X., Siu K.Y., Wong E.S.Y., Ngan H.Y.S., Chan K.Y.Q., Li A.S.M., Khoo U.S. and Cheung A.N.Y., Hypermethylation of RAS effector related genes and DNA methyltransferase 1 expression in endometrial carcinogenesis, Int J Cancer. 2008, 123(2): 296-302.

Liao X., Chan Y.K., Chan I.L.S., Wong K.Y., Wong E.S.Y., Chan H.Y., Siu K.Y., Khoo U.S., Ngan H.Y.S. and Cheung A.N.Y., Kinesin family member 7 (KIF7) in endometrial and ovarian cancers , The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18 - 22 April 2009. . 2009.

Siu K.Y., Wong E.S.Y., Chan H.Y., Ngan H.Y.S., Chan Y.K. and Cheung A.N.Y., Overexpression of NANOG in Gestational Trophoblastic Diseases. Effect on Apoptosis, Cell Invasion, and Clinical Outcome, Am J Pathol. 2008, [Epub ahead of print].

Zhang H., Siu K.Y., Wong E.S.Y., Chan H.Y., Ngan H.Y.S. and Cheung A.N.Y., Activation of PKB/AKT promotes cell survival and invasion in choriocarcinoma, The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18 - 22 April 2009.. 2009.

Zhao F., Siu K.Y., Wong E.S.Y., Chan H.Y., Jiang L., Ngan H.Y.S. and Cheung A.N.Y., Overexpression of Dock180 in ovarian cancer, The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18 - 22 April 2009.. 2009.

Researcher : Wong KY

List of Research Outputs

Au W.Y., Wong K.Y., Wan T.S.K., So J.C.C., Srivastava G. and Liang R.H.S., A unique case of B cell lymphoma relapsing as CD4/CD56 blastic neoplasm, Leuk Lymphoma . 2009, 50(6): 932-6.

Au W.Y., Wong K.Y., Leung R.Y.Y. and Tong A.C.K., Isolated gingival relapse of acute lymphoblastic leukemia after transplantation, Journal of Oral Pathology & Medicine. 2008, 37(4): 249-251.

Hwang Y.Y., Wong K.Y., Leung R.Y.Y., Wong S.H., Chan S.C., Srivastava G. and Au W.Y., Post-rituximab Burkitt transformation of PTLD: loss of CD20 expression accompanied by a switch in light-chain expression, Ann Hematol. 2009, [Epub ahead of print].

Liao X., Chan Y.K., Chan I.L.S., Wong K.Y., Wong E.S.Y., Chan H.Y., Siu K.Y., Khoo U.S., Ngan H.Y.S. and Cheung A.N.Y., Kinesin family member 7 (KIF7) in endometrial and ovarian cancers , The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18 - 22 April 2009. . 2009.

Ma S.K.Y., Chan Y.P., Woolcock B., Hu L., Wong K.Y., Ling M.T., Bainbridge T., Webber D., Chan H.M., Guan X.Y., Lam W., Vielkind J. and Chan K.W., DNA fingerprinting tags novel altered chromosomal regions and identifies the involvement of SOX5 in the progression of prostate cancer, International Journal of Cancer. 2009, 124: 2323-2332.

Shen L., Au W.Y., Wong K.Y., Shimizu N., Tsuchiyama J., Kwong Y.L., Liang R.H.S. and Srivastava G., Cell death by bortezomib-induced mitotic catastrophe in natural killer lymphoma cells, Molecular Cancer Therapeutics. 2008, 7(12): 3807-15.

Researcher : Wong MP

List of Research Outputs

Chua D.T.T., Wei W.I., Wong M.P., Sham J.S.T., Nicholls J.M. and Au G.K.H., Phase II study of gefitinib for the treatment of recurrent and metastatic nasopharyngeal carcinoma, Head & Neck. 2008, 30(7): 863-7.

Ho P.L., Wong M.P., Lai E.L.Y., Chan K.H. and Chiu S.S.S., DNA typing of cytological samples for retrospective identification of an early case of Panton-Valentine leucocidin-positive, community-associated methicillin-resistant Staphylococcus aureus pneumonia, J Clin Microbiol. 2008, 46: 2457-2458.

Lam B., Lam S.Y., Wong M.P., Ooi C.G.C., Fong D.Y., Lam C.L., Lai A.Y., Tam C.M., Pang C.B.Y., Ip M.S.M. and Lam W.K., Sputum Cytology Examination Followed By Autofluorescence Bronchoscopy: A Practical Way Of Identifying Early Stage Lung Cancer In Central Airway, Lung Cancer. 2009, 64: 289-294.

Leung L.H., Tam I.Y., Tin P.C., Chua D.T.T., Sihoe A.D.L., Cheung L.C., Ho J.C.M., Chung L.P. and Wong M.P., Src Promotes Survival and Invasion of Lung Cancers with Epidermal Growth Factor Receptor Abnormalities and Is a Potential Candidate for Molecular-Targeted Therapy., Molecular Cancer Research. 2009, 7(6): 923-32.

Nicholls J.M., Chan M.C.W., Chan W.Y., Cheung C.Y., Kwong D.L.W., Wong M.P., Poon L.L.M., Tsao G.S.W. and Guan Y., 2008 Research Output Prize/Faculty Outstanding Research Output Award, The University of Hong Kong. 2008.

So K.T., Tam I.Y., Leung L.H., Tin P.C., Wong W.S., Sihoe A.D.L., Cheng L.C., Chung L.P. and Wong M.P., Mutational analysis of EGFR-related genes in non-small cell lung cancer (Poster), American Association for Cancer Research Annual Meeting, 2009 April 18-22, 2009, Denver, Colorado, the United State . 2009.

Tam I.Y., Leung L.H., Tin P.C., Chua D.T.T., Sihoe A.D.L., Cheng L.C., Chung L.P. and Wong M.P., EGFR mutants containing rare EGFR mutant types show reduced response to in-vitro gefitinib compared to common activating missense mutations (Poster), American Association for Cancer Research Annual Meeting, 2009 April 18-22, 2009, Denver, Colorado, the United State . 2009.

Wong M.K.Y., Wong M.P., Lam C.L., Sihoe A.D.L., Cheng L.C., Lam B., Ip M.S.M., Nakajima T., Yasufuku K., Lam W.K. and Ho J.C.M., Endobronchial ultrasound for diagnosis of synchronous primary lung cancers, Lung Cancer. 2009, 63: 154-157.

Wong W.S., Leung L.H., Tin P.C., Sihoe A.D.L., Cheng L.C., Chung L.P. and Wong M.P., ALK kinase domain is aberrantly expressed but not mutated in Chinese non-small cell lung cancer from male smokers with squamous cell carcinoma (Poster), American Association for Cancer Research Annual Meeting, 2009 April 18-22, 2009, Denver, Colorado, the United State . 2009.

Wong W.S., Leung L.H., So K.T., Tam Y.S.I., Sihoe A.D.L., Cheng L.C., Ho K.K., Au J.S., Chung L.P. and Wong M.P., The Eml4-alk Fusion Gene Is Involved In Various Histologic Types Of Lung Cancers From Nonsmokers With Wild-type Egfr And Kras, Cancer. 2009, 115: 1723-1733.

Researcher : Wong SY

List of Research Outputs

Ip Y.C., Chan Y.K., Wong S.Y., Cheung S.T. and Khoo U.S., Targeting granulin-epithelin precursor in breast cancer , The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18 - 22 April 2009. . 2009.

Researcher : Wong WS

List of Research Outputs

So K.T., Tam I.Y., Leung L.H., Tin P.C., Wong W.S., Sihoe A.D.L., Cheng L.C., Chung L.P. and Wong M.P., Mutational analysis of EGFR-related genes in non-small cell lung cancer (Poster), American Association for Cancer Research Annual Meeting, 2009 April 18-22, 2009, Denver, Colorado, the United State . 2009.

Wong W.S., Leung L.H., Tin P.C., Sihoe A.D.L., Cheng L.C., Chung L.P. and Wong M.P., ALK kinase domain is aberrantly expressed but not mutated in Chinese non-small cell lung cancer from male smokers with squamous cell carcinoma (Poster), American Association for Cancer Research Annual Meeting, 2009 April 18-22, 2009, Denver, Colorado, the United State . 2009.

Wong W.S., Leung L.H., So K.T., Tam Y.S.I., Sihoe A.D.L., Cheng L.C., Ho K.K., Au J.S., Chung L.P. and Wong M.P., The Eml4-alk Fusion Gene Is Involved In Various Histologic Types Of Lung Cancers From Nonsmokers With Wild-type Egfr And Kras, Cancer. 2009, 115: 1723-1733.

Researcher : Xue W

List of Research Outputs

Chan K.Y.Q., Ngan H.Y.S., Ip P.P.C., Liu V.W.S., Xue W. and Cheung A.N.Y., Tumor suppressor effect of follistatin-like 1 in ovarian and endometrial carcinogenesis: a differential expression and functional analysis, Carcinogenesis. Oxford Journals, 2009, 30: 114-121.

Cheung A.N.Y., Zhang H., Xue W. and Siu K.Y., Pathogenesis of choriocarcinoma: clinical, genetic and stem cell perspectives, Future Oncology. 2009, 5(2): 217-231.

Researcher : Yam JWP

List of Research Outputs

Chan L.K., Ko F.C.F., Ng I.O.L. and Yam J.W.P., Deleted in liver cancer 1 (DLC1) utilizes a novel binding site for Tensin2 PTB domain interaction and is required for tumor-suppressive function, PLoS One. 2009, 4: e5572.

Ko F.C.F., Chan L.K., Ng I.O.L. and Yam J.W.P., Post-translational modification of Deleted in Liver Cancer 1 (DLC1) tumor suppressor, The 6th International Meeting Hepatocellular Carcinoma: Eastern and Western Experiences, Seoul, Korea. 2008.

Tse Y.T. and Yam J.W.P., Role of caveolin-1 in hepatocellular carcinoma carcinogenesis and metastasis, 15th Hong Kong International Cancer Congress and 5th Annual Meeting Centre for Cancer Research, Hong Kong.. 2008, Abstract No. A25.

Tse Y.T., Ko F.C.F., Lee K.W., Ngan E.S.W., Ng I.O.L. and Yam J.W.P., Upregulation of caveolin-1 in human hepatocellular carcinoma, American Association for Cancer Research 100th Annual Meeting, Denver, Colorado, USA, 2009.

Wong C.C.L., Wong C.M., Ko F.C.F., Chan L.K., Ching Y.P., Yam J.W.P. and Ng I.O.L., Deleted in liver cancer 1 (DLC1) negatively regulates Rho/ROCK/MLC pathway in hepatocellular carcinoma, PLoS One. 2008, 3: e2779.

Yam J.W.P., Focal adhesion localization and tumor suppressor activity of DLC1, 13th World Congress on Advances in Oncology and 11th International Symposium on Molecular Medicine, Crete, Greece. 2008.

Yam J.W.P., Ko F.C.F., Chan L.K. and Ng I.O.L., Functional implications of Akt phosphorylation of Deleted in Liver Cancer 1 (DLC1), American Association for Cancer Research 100th Annual Meeting, Denver, Colorado, USA. 2009.

Yam J.W.P., Tse Y.T. and Ng I.O.L., Role and significance of focal adhesion proteins in hepatocellular carcinoma, J Gastroenterol Hepatol. 2009, 24: 520-530.

Yam J.W.P., Role of focal adhesion proteins in hepatocellular carcinoma, College of Life Sciences, Nankai University . 2009.

Yam J.W.P., UK-HK Frontiers of Science Symposium, Organised in Hong Kong by the Royal Society, with the support of the Croucher Foundation and the Department of Biochemistry, Hong Kong University of Science and Technology. 2009.

Researcher : Yau TO

List of Research Outputs

Tung K.K., Wong C.M., Yau T.O., Lee M.F., Ching Y.P. and Ng I.O.L., HAI-2 is epigenetically downregulated in human hepatocellular carcinoma, and its Kunitz domain type 1 is critical for anti-invasive functions. , International Journal of Cancer. 2009, 124: 1811.

Yau T.O., Chan C.F., Lam S.G.S., Cheung O.F., Ching Y.P., Jin D., Sham M.H. and Ng I.O.L., Hepatocyte-specific activation of NF-KB does not aggravate chemical hepatocarcinogenesis in transgenic mice, The Journal of Pathology. 2008, 217: 353-361.

Researcher : Yip SF

List of Research Outputs

So J.C.C., Leung R.Y.Y., Yip S.F., Lam C.C.K. and Chan L.C., Invasive Streptococcus pneumoniae infection associated with hemolytic uremic syndrome in Chinese pediatric patients. , 50th American Society of Hematology Annual Meeting and Expositions, USA. 2008.

Sun Q., So J.C.C., Yip S.F., Wan T.S.K., Ma E.S.K. and Chan L.C., Functional alterations of Lin-CD34+CD38+ cells in chronic myelomonocytic leukemia and on progression to acute leukemia, Leuk Res. 2008, 32(9): 1374-1381.

Researcher : Yuen HF

List of Research Outputs

Yuen H.F., Chan Y.P., Law S.Y.K., Srivastava G., E1-tanani M., Mak T.W. and Chan K.W., DJ-1 could predict worse prognosis in esophageal squamous cell carcinoma, Cancer Epidemiology, Biomarkers & Prevention. 2008, 17(12): 3593-3602.

Yuen H.F., Kwok W.K., Chan K.K., Chua C.W., Chan Y.P., Chu Y.Y., Wong Y.C., Wang X. and Chan K.W., TWIST modulates prostate cancer cell-mediated bone cell activity and is upregulated by osteogenic induction, Carcinogenesis. 2008, 29(8): 1509-18.

Researcher : Yuen ST

List of Research Outputs

Chan T.L., Yuen S.T., Kuiper R.P., Lee T.Y.H., Tsui W.Y., Lau J.K.Y., Li C., Chan K.W., Kong C.K., Chan A.S.Y., Ligtenberg M.J.L. and Leung S.Y., Deletion of the 3’ Exons of TACSTD1 Causes Hereditary Nonpolyposis Colorectal Cancer with MSH2 Gene Promoter Methylation, The 3rd Biennial Meeting of The International Society for Gastrointestinal Hereditary Tumours (InSiGHT), Dusseldorf, Germany. 2009.

Ligtenberg M.J., Kuiper R.P., Chan T.L., Goossens M., Hebeda K.M., Voorendt M., Lee T.Y.H., Bodmer D., Hoenselaar E., Hendriks-Cornelissen S.J., Tsui W.Y., Kong C.K., Brunner H.G., van Kessel A.G., Yuen S.T., van Krieken J.H., Leung S.Y. and Hoogerbrugge N., Heritable somatic methylation and inactivation of MSH2 in families with Lynch syndrome due to deletion of the 3' exons of TACSTD1, Nat Genet. 2009, 41(1): 112-7.

van Haaften G., Dalgliesh G.L., Davies H., Chen L., Bignell G., Greenman C., Edkins S., Hardy C., O'Meara S., Teague J., Butler A., Hinton J., Latimer C., Andrews J., Barthorpe S., Beare D., Buck G., Campbell P.J., Cole J., Forbes S., Jia M., Jones D., Kok C.Y., Leroy C., Lin M.L., McBride D.J., Maddison M., Maquire S., McLay K., Menzies A., Mironenko T., Mulderrig L., Mudie L., Pleasance E., Shepherd R., Smith R., Stebbings L., Stephens P., Tang G., Tarpey P.S., Turner R., Turrell K., Varian J., West S., Widaa S., Wray P., Collins V.P., Ichimura K., Law S.Y.K., Wong J., Yuen S.T., Leung S.Y., Tonon G., DePinho R.A., Tai Y.T., Anderson K.C., Kahnoski R.J., Massie A., Khoo S.K., Teh B.T., Stratton M.R. and Futreal P.A., Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer, Nature Genetics. 2009, 41(5): 521-523.

Researcher : Zhang H

List of Research Outputs

Chan H.Y., Siu K.Y., Zhang H., Wong E.S.Y., Ngan H.Y.S., Chan K.Y.Q. and Cheung A.N.Y., Activated Stat3 expression in gestational trophoblastic disease: correlation with clinicopathological parameters and apoptotic indices, Histopathology. 2008, 53(2): 139-146.

Cheung A.N.Y., Zhang H., Xue W. and Siu K.Y., Pathogenesis of choriocarcinoma: clinical, genetic and stem cell perspectives, Future Oncology. 2009, 5(2): 217-231.

Zhang H., Siu K.Y., Wong E.S.Y., Chan H.Y., Ngan H.Y.S. and Cheung A.N.Y., Activation of PKB/AKT promotes cell survival and invasion in choriocarcinoma, The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18 - 22 April 2009.. 2009.

Zhang H., Xue W.C., Siu K.Y., Liao X., Ngan H.Y.S. and Cheung A.N.Y., P63 Expression in Gestational Trophoblastic Disease: Correlation With Proliferation and Apoptotic Dynamics., Int. J. Gynecol. Pathol. . 2009, 28: 172-178.

Researcher : Zhang H

List of Research Outputs

Cheung A.N.Y., Zhang H., Xue W. and Siu K.Y., Pathogenesis of choriocarcinoma: clinical, genetic and stem cell perspectives, Future Oncology. 2009, 5(2): 217-231.

Researcher : Zhao F

List of Research Outputs

Zhao F., Siu K.Y., Wong E.S.Y., Chan H.Y., Jiang L., Ngan H.Y.S. and Cheung A.N.Y., Overexpression of Dock180 in ovarian cancer, The 100th Annual Meeting of the American Association for Cancer Research, Denver, Colorado, U.S.A., 18 - 22 April 2009.. 2009.

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