DEPT OF CLINICAL ONCOLOGY



Researcher : CAO T
List of Research Outputs

Li Y., Fu L., Qin Y.R., Zeng T., Zhou J., Zeng Z.L., CHEN J., CAO T., Ban X., Qian C., Cai Z., Xie D., Huang P. and Guan X., Increased expression of EIF5A2, via hypoxia or gene amplification, contributes to metastasis and angiogenesis of esophageal squamous cell carcinoma, Gastroenterology. 2014, 146(7): 1701-1713.


Researcher : CHAN KC
List of Research Outputs

Lung H.L., MAN O.Y., YEUNG M.C., Ko J.M.Y., Cheung A.K.L., LAW W.L., Yu Z., SHUEN W.H., Tung E., Chan S.H.K., Bangarusamy D.K., Cheng Y., YANG X., KAN P.Q.R., PHOON Y.P., CHAN K.C., CHUA D., Kwong D.L.W., Lee A.W.M., Ji M.F. and Lung M.L., SAA1 polymorphisms are associated with variation in antiangiogenic and tumor-suppressive activities in nasopharyngeal carcinoma, Oncogene. 2014.


Researcher : CHAN KH
List of Research Outputs

CHAN K.H., Kwong D.L.W., Law G.M., Tam E., Tong A., Lee V. and Ng C.Y., Dosimetric evaluation of four-dimensional dose distributions of CyberKnife and volumetric-modulated arc radiotherapy in stereotactic body lung radiotherapy, Journal of Applied Clinical Medical Physics . 2013, 14(4): 4229.
CHAN K.H., Kwong D.L.W., Tong A., Tam E. and Ng C.Y., Evaluation of dose prediction error and optimization convergence error in four-dimensional inverse planning of robotic stereotactic lung radiotherapy , Journal of Applied Clinical Medical Physics. 2013, Vol. 14 , No. 4: 4270.
CHAN K.H., Kwong D.L.W., Tam E., Tong A. and Ng C.Y., Quantifying variability of intrafractional target motion in stereotactic body radiotherapy for lung cancers , Journal of Applied Clinical Medical Physics. 2013, 14(5): 140-52.


Researcher : CHEN J
List of Research Outputs

Li Y., Fu L., Qin Y.R., Zeng T., Zhou J., Zeng Z.L., CHEN J., CAO T., Ban X., Qian C., Cai Z., Xie D., Huang P. and Guan X., Increased expression of EIF5A2, via hypoxia or gene amplification, contributes to metastasis and angiogenesis of esophageal squamous cell carcinoma, Gastroenterology. 2014, 146(7): 1701-1713.
Liu L., Dai Y., CHEN J., Zeng T., Li Y., Chen L., Zhu Y.H., Li J., Li Y., Ma S.K.Y., Xie D., Yuan Y.F. and Guan X., Maelstrom promotes hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition by way of Akt/GSK-3b signaling, Hepatology. 2014, 59: 531-543.
Liu L., Dai Y., CHEN J., Zeng T., Li Y., Chen L., Zhu Y., Li J., Li Y., Xie D., Yuan Y.F. and Guan X., Maelstrom promotes hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition via Akt/GSK-3β/Snail signaling, Hepatology. 2014, 59(2): 531-543.
Liu M., Li Y., Chen L., Chan H.M., SONG Y., Fu L., Zeng T.T., Dai Y.D., Zhu Y.H., Li Y., CHEN J., Yuan Y.F. and Guan X., Allele-specific imbalance of oxidative stress-induced growth inhibitor 1 associates with progression of hepatocellular carcinoma, Gastroenterology. 2014, 146(4): 1084-1096.


Researcher : Chan HM
List of Research Outputs

Chan H.M., Lin C.H., Qi L., Fei J., Li Y., Yong K.J., Liu M., SONG Y., Chow K.K., Ng V.H., Yuan Y.F., Tenen D.G., Guan X. and Chen L., A disrupted RNA editing balance mediated by ADARs (Adenosine DeAminases that act on RNA) in human hepatocellular carcinoma, Gut. 2014, 63(5): 832-843.
Li Y., Chen L., Chan H.M. and Guan X., Hepatocellular carcinoma: transcriptome diversity regulated by RNA editing, International Journal of Biochemistry & Cell Biology. 2013, 45(8): 1843-1848.
Liu M., Li Y., Chen L., Chan H.M., SONG Y., Fu L., Zeng T.T., Dai Y.D., Zhu Y.H. and Li Y., Allele-Specific Imbalance of Oxidative Stress-Induced Growth Inhibitor 1 Associates With Progression of Hepatocellular Carcinoma, Gastroenterology. 2014, 146: 1084-1096.e5.
Liu M., Li Y., Chen L., Chan H.M., SONG Y., Fu L., Zeng T.T., Dai Y.D., Zhu Y.H., Li Y., CHEN J., Yuan Y.F. and Guan X., Allele-specific imbalance of oxidative stress-induced growth inhibitor 1 associates with progression of hepatocellular carcinoma, Gastroenterology. 2014, 146(4): 1084-1096.
Qin Y.R., Qiao J.J., Chan H.M., Zhu Y.H., Liu H., Fei J., Li Y., Guan X. and Chen L., Adenosine-to-inosine RNA editing mediated by ADARs in esophageal squamous cell carcinoma (ESCC), Cancer Research. 2014, 74(3): 840-851.


Researcher : Chan OSH
List of Research Outputs

Lee A.W.M., Ng W.T., Chan L.L., Hung W.M., Chan C.C., Sze C.K.H., Chan O.S.H., Chang A.T. and Yeung M.W.R., Evolution of treatment for nasopharyngeal cancer--success and setback in the intensity-modulated radiotherapy era, In: Jens Overgaard, Radiother Oncol.. Radiother Oncol., 2014, 110: 377-384.
Sze C.K.H., Chan L.K.L., Ng W.T., Hung W.M.A., Lee C.H.M., Chang T.Y.A., Chan O.S.H., Cheung F.Y., Yeung M.W.R. and Lee A.W.M., The prognostic significance of masticator space involvement in nasopharyngeal carcinoma. , 咀嚼肌间隙侵犯对鼻咽癌分期影响的重要意义, The 9th Pan-Pearl-River Area Congress of Radiation Oncology. 第九届泛珠会议, 2014.


Researcher : Chen L
List of Research Outputs

Chan H.M., Lin C.H., Qi L., Fei J., Li Y., Yong K.J., Liu M., SONG Y., Chow K.K., Ng V.H., Yuan Y.F., Tenen D.G., Guan X. and Chen L., A disrupted RNA editing balance mediated by ADARs (Adenosine DeAminases that act on RNA) in human hepatocellular carcinoma, Gut. 2014, 63(5): 832-843.
Li Y., Chen L., Chan H.M. and Guan X., Hepatocellular carcinoma: transcriptome diversity regulated by RNA editing, International Journal of Biochemistry & Cell Biology. 2013, 45(8): 1843-1848.
Liu L., Dai Y., CHEN J., Zeng T., Li Y., Chen L., Zhu Y.H., Li J., Li Y., Ma S.K.Y., Xie D., Yuan Y.F. and Guan X., Maelstrom promotes hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition by way of Akt/GSK-3b signaling, Hepatology. 2014, 59: 531-543.
Liu L., Dai Y., CHEN J., Zeng T., Li Y., Chen L., Zhu Y., Li J., Li Y., Xie D., Yuan Y.F. and Guan X., Maelstrom promotes hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition via Akt/GSK-3β/Snail signaling, Hepatology. 2014, 59(2): 531-543.
Liu M., Li Y., Chen L., Chan H.M., SONG Y., Fu L., Zeng T.T., Dai Y.D., Zhu Y.H. and Li Y., Allele-Specific Imbalance of Oxidative Stress-Induced Growth Inhibitor 1 Associates With Progression of Hepatocellular Carcinoma, Gastroenterology. 2014, 146: 1084-1096.e5.
Liu M., Li Y., Chen L., Chan H.M., SONG Y., Fu L., Zeng T.T., Dai Y.D., Zhu Y.H., Li Y., CHEN J., Yuan Y.F. and Guan X., Allele-specific imbalance of oxidative stress-induced growth inhibitor 1 associates with progression of hepatocellular carcinoma, Gastroenterology. 2014, 146(4): 1084-1096.
Qin Y.R., Qiao J.J., Chan H.M., Zhu Y.H., Liu H., Fei J., Li Y., Guan X. and Chen L., Adenosine-to-inosine RNA editing mediated by ADARs in esophageal squamous cell carcinoma (ESCC), Cancer Research. 2014, 74(3): 840-851.
Wong A.M.G., Kong K.L., Chen L., Liu M., Wong A.M.G., Zhu C., Tsang J.W.H. and Guan X., Characterization of CACNA2D3 as a putative tumor suppressor gene in the development and progression of nasopharyngeal carcinoma , International Journal of Cancer. 2013, 133: 2284-2295.


Researcher : Cheng CK
List of Research Outputs

Wu Y.L., Lee J.S., Thongprasert S., Yu C.J., Zhang L., Ladrera G., Srimuninnimit V., Sriuranpong V., Sandoval-Tan J., Zhu Y., Liao M., Zhou C., Pan H., Lee V.H.F., Chen Y.M., Sun Y., Margono B., Fuerte F., Chang G.C., Seetalarom K., Wang J., Cheng C.K., Syahruddin E., Qian X., Ho J.C.M., Kurnianda J., Liu H.E., Jin K., Truman M., Bara I. and Mok T., Intercalated combination of chemotherapy and erlotinib for patients with advanced stage non-small-lung cancer (FASTACT-2): a randomised, double-blind trial, Lancet Oncology. Science Direct, 2013, 14: 777-786.


Researcher : Cheng Y
Project Title:Wnt-signaling defines cancer stem cells and epithelial-mesenchymal transition
Investigator(s):Cheng Y, Lung ML
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:02/2012
Completion Date:01/2014


Project Title:A novel tumor suppressive pathway mediated by BLU gene in nasopharyngeal carcinoma
Investigator(s):Cheng Y, Lung ML
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:11/2012


List of Research Outputs

Cheng Y., PHOON Y.P. and Lung M.L., Inhibition of both physiological and aberrant Wnt/beta-catenin signaling activities in nasopharyngeal carcinoma, American Association for Cancer Research Annual Meeting 2014.
Cheng Y., Cheung A.K.L., Ko J.M.Y., PHOON Y.P., Chiu P.M., Lo P.H., Waterman M.L. and Lung M.L., Physiological beta-catenin signaling controls self-renewal networks and generation of stem-like cells from nasopharyngeal carcinoma, BMC Cell Biol. BMC, 2013, 14(1): 44.
Cheng Y. and Lung M.L., inhibition of both physiological and aberrant Wnt/b-catenin signaling activities associated with stemness in NPC, 105th American Association of Cancer Research. 2014.
Lung H.L., MAN O.Y., YEUNG M.C., Ko J.M.Y., Cheung A.K.L., LAW W.L., Yu Z., SHUEN W.H., Tung E., Chan S.H.K., Bangarusamy D.K., Cheng Y., YANG X., KAN P.Q.R., PHOON Y.P., CHAN K.C., CHUA D., Kwong D.L.W., Lee A.W.M., Ji M.F. and Lung M.L., SAA1 polymorphisms are associated with variation in antiangiogenic and tumor-suppressive activities in nasopharyngeal carcinoma, Oncogene. 2014.
YANG X., Dai W., Szeto C.Y.Y., Cheng Y., Kwong D.L.W. and Lung M.L., Epigenetic markers for early detection of NPC, 18th postgraduate symposium HKU. 2013.


Researcher : Cheung AKL
Project Title:Investigation of the role of Epstein-Barr Virus in epigenetic regulation in nasopharyngeal carcinoma
Investigator(s):Cheung AKL, Lung ML
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:01/2012


Project Title:Investigation of EBV-associated host cell histone modification and gene expression changes in nasopharyngeal carcinoma by next generation sequencing
Investigator(s):Cheung AKL, Lung ML, Tsao GSW
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:08/2013


List of Research Outputs

Cheng Y., Cheung A.K.L., Ko J.M.Y., PHOON Y.P., Chiu P.M., Lo P.H., Waterman M.L. and Lung M.L., Physiological beta-catenin signaling controls self-renewal networks and generation of stem-like cells from nasopharyngeal carcinoma, BMC Cell Biol. BMC, 2013, 14(1): 44.
Cheung A.K.L., Ip J.C.Y., Lung H.L., Wu J.Z., Tsao G.S.W. and Lung M.L., Polo-like Kinase Inhibitor Ro5203280 Has Potent Antitumor Activity in Nasopharyngeal Carcinoma, Molecular cancer therapeutics. 2013.
KAN P.Q.R., Cheung A.K.L. and Lung M.L., NPC candidate tumor-suppressive ECM protein, LTBP2, mediates its effects via the pleiotropic transcription factor NFkB pathway, 18th Postgraduate Symposium HKU. 2013.
Lung H.L., MAN O.Y., YEUNG M.C., Ko J.M.Y., Cheung A.K.L., LAW W.L., Yu Z., SHUEN W.H., Tung E., Chan S.H.K., Bangarusamy D.K., Cheng Y., YANG X., KAN P.Q.R., PHOON Y.P., CHAN K.C., CHUA D., Kwong D.L.W., Lee A.W.M., Ji M.F. and Lung M.L., SAA1 polymorphisms are associated with variation in antiangiogenic and tumor-suppressive activities in nasopharyngeal carcinoma, Oncogene. 2014.
PHOON Y.P., Cheung A.K.L. and Lung M.L., The tumor suppressive role of IKBb, a NFkB inhibitor, in NPC, 18th Postgraduate symposium HKU. 2013.


Researcher : Cheung FY
List of Research Outputs

Sze C.K.H., Chan L.K.L., Ng W.T., Hung W.M.A., Lee C.H.M., Chang T.Y.A., Chan O.S.H., Cheung F.Y., Yeung M.W.R. and Lee A.W.M., The prognostic significance of masticator space involvement in nasopharyngeal carcinoma. , 咀嚼肌间隙侵犯对鼻咽癌分期影响的重要意义, The 9th Pan-Pearl-River Area Congress of Radiation Oncology. 第九届泛珠会议, 2014.


Researcher : Cheung YT
List of Research Outputs

Lee V.H.F., Kwong D.L.W., Lam K.O., Leung D.K.C., Ho P.P.Y., Cheung Y.T., Wong S.Y., Tsang J.W.H. and Leung T.W., Pre-treatment EBV DNA differentiates different stages of undifferentiated carcinoma of the nasopharynx, European Cancer Congress 2013. Amsterdam, European Cancer Organisation.


Researcher : Chow KK
List of Research Outputs

Chan H.M., Lin C.H., Qi L., Fei J., Li Y., Yong K.J., Liu M., SONG Y., Chow K.K., Ng V.H., Yuan Y.F., Tenen D.G., Guan X. and Chen L., A disrupted RNA editing balance mediated by ADARs (Adenosine DeAminases that act on RNA) in human hepatocellular carcinoma, Gut. 2014, 63(5): 832-843.


Researcher : Choy TS
List of Research Outputs

Chan W.L., Lee V.H.F., Choy T.S. and Leung T.W., Pineal Parenchymal Tumor of Intermediate Differentiation: two cases treated with adjuvant radiotherapy, 20th Hong Kong International Cancer Congress. Hong Kong, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 2013.
Lee V.H.F., Tin P.C., Choy T.S., Lam K.O., Choi C.W., Chung L.P., Tsang J.W.H., Ho P.P., Leung D.K., Ma E.S., Liu J., Shek T.W.H., Kwong D.L.W., Leung T.W. and Wong M.P., Association of Exon 19 and 21 EGFR Mutation Patterns with Treatment Outcome after First-Line Tyrosine Kinase Inhibitor in Metastatic Non-Small-Cell Lung Cancer, In: Lee VH, Tin VP, Choy TS, Lam KO, Choi CW, Chung LP, Tsang JW, Ho PP, Leung DK, Ma ES, Liu J, Shek TW, Kwong DL, Leung TW, Wong MP, J Thorac Oncol. 2013, 8(9):1148-55.
Lee V.H.F., Chan W.W., Lee E.Y.P., Choy T.S., Ho P.P., Leung D.K., Lam K.O., Kwong D.L.W., Leung T.W. and Khong P.L., Prognostic Significance of Standardized Uptake Value of Lymph Nodes on Survival for Stage III Non-Small Cell Lung Cancer Treated With Definitive Concurrent Chemoradiotherapy, American Journal of Clinical Oncology . Lippincott Williams & Wilkins, Inc, 2014, Published Ahead-of-Print.


Researcher : Chua DTT
Project Title:2000 Annual Meeting of the American Society for Therapeutic Radiology and Oncology Patterns of Failure after Induction Chemotherapy and Radiotherapy for Loco-Regionally Advanced Nasopharyngeal Carcinoma: The Queen Mary Hospital Experience
Investigator(s):Chua DTT
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2000


Project Title:2001 Annual Scientific Meeting of the American Society for Therapeutic Radiology and Oncology Control of Regional Metastasis after Induction Chemotherapy and Radiotherapy for Nasopharyngeal Carcinoma
Investigator(s):Chua DTT
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:11/2001


Project Title:The Radiological Society of North America 89th Scientific Assembly and Annual Meeting Prognostic Value of Tumor Volume in Early Stage Nasopharyngeal Carcinoma Treated by Radiotherapy
Investigator(s):Chua DTT
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:11/2003


Project Title:46th Annual Meeting of the American Society for Therapeutic Radiology and Oncology Prognostic Impact of Hemoglobin Level on Treatment Outcome in Patients with Nasopharyngeal Carcinoma Treated with Sequential Chemoradiotherapy or Radiotherapy Alone
Investigator(s):Chua DTT
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2004


Project Title:Nasopharyngeal Carcinoma (NPC)
Investigator(s):Chua DTT, Nicholls JM
Department:Clinical Oncology
Source(s) of Funding:Croucher Foundation - Research Grants
Start Date:01/2007




Researcher : Dai W
Project Title:Pilot Study for Deciphering Methylome of Nasopharyngeal Carcinoma (NPC)
Investigator(s):Dai W, Lung ML
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:05/2014


List of Research Outputs

Dai W. and Lung M.L., Small Project Funding - “Pilot Study for Deciphering Methylome of Nasopharyngeal Carcinoma (NPC)” HK$51,732, University Research Committee. 2014.
Ko J.M.Y., Dai W., Wong H.W.E., Kwong D.L.W., Ng W.T., Lee A.W.M., Ngan R.C.K., Yau C.C., Tung S. and Lung M.L., Multigene pathway-based analyses identify nasopharyngeal carcinoma risk associations for cumulative adverse effects of TERT-CLPTM1L and DNA double-strand breaks repair , International Journal of Cancer. 2014, n/a-n/a.
Lung M.L., Ko J.M.Y., Dai W., Wong H.W.E., Kwong D.L.W., Ng W.T., Lee A., Ngan R.K., Yau C.C. and Tung S., Adverse effects if TERT-CLPTM1L and double-strand breaks repair contribute to risk for NPC, 105th AACR. 2014.
YANG X., Dai W., Szeto C.Y.Y., Cheng Y., Kwong D.L.W. and Lung M.L., Epigenetic markers for early detection of NPC, 18th postgraduate symposium HKU. 2013.


Researcher : Fu L
Project Title:Epigenetic Alteration of Organic Cation Transporter Gene SLC22A3 Confers Susceptibility To Esophageal Cancer in The High-Risk Northern Chinese
Investigator(s):Fu L, Guan X
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012
Completion Date:05/2014


Project Title:Characterization of WNT2 in the esophageal cancer microenvironment: prognostic and therapeutic implications
Investigator(s):Fu L, Zhang M, Guan X
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2014
Completion Date:11/2013


List of Research Outputs

Li J.C., Li Y., Ai J.Y., Chen K., Zhu Y.H., Fu L., Qin Y.R., Wang L.J. and Guan X., Podoplanin positive cancer cells at the edge of esophageal squamous cell carcinomas are involved in invasion, Molecular Medicine Reports. 2014, 10(3): 1513-1518.
Li Y., Fu L., Qin Y.R., Zeng T., Zhou J., Zeng Z.L., CHEN J., CAO T., Ban X., Qian C., Cai Z., Xie D., Huang P. and Guan X., Increased expression of EIF5A2, via hypoxia or gene amplification, contributes to metastasis and angiogenesis of esophageal squamous cell carcinoma, Gastroenterology. 2014, 146(7): 1701-1713.
Liu M., Li Y., Chen L., Chan H.M., SONG Y., Fu L., Zeng T.T., Dai Y.D., Zhu Y.H. and Li Y., Allele-Specific Imbalance of Oxidative Stress-Induced Growth Inhibitor 1 Associates With Progression of Hepatocellular Carcinoma, Gastroenterology. 2014, 146: 1084-1096.e5.
Liu M., Li Y., Chen L., Chan H.M., SONG Y., Fu L., Zeng T.T., Dai Y.D., Zhu Y.H., Li Y., CHEN J., Yuan Y.F. and Guan X., Allele-specific imbalance of oxidative stress-induced growth inhibitor 1 associates with progression of hepatocellular carcinoma, Gastroenterology. 2014, 146(4): 1084-1096.


Researcher : Guan X
Project Title:49th Annual Meeting of the American Society of Human Genetics The Association of Chromosome 8p Deletion and Tumor Metastasis in Human Hepatocellular Carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/1999


Project Title:51st Annual Meeting of the American Society of Human Genetics Loss of Tyrosine Aminotransferase may Contribute to the Development of Hepatocellular Carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2001


Project Title:Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:03/2009


Project Title:Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:03/2009


Project Title:Mass spectrometry-based metabolomics for the characterization of cellular metabolic pathways associated with the development of hepatocellular carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:04/2011
Completion Date:03/2014


Project Title:Characterization of tumor suppressive function and mechanism of CHL1 at a frequent deleted region 3p26.3 in esophageal squamous cell carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2011
Completion Date:09/2013


Project Title:The Liver Cancer Genome Project: translating genetic discoveries to clinical benefits
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Theme-based Research Scheme
Start Date:12/2011


Project Title:Characterization of the role of Epstein-Barr virus encoded microRNA BART19-3p in enhancing tumor-initiating properties in nasopharyngeal carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012
Completion Date:05/2014


Project Title:A novel strategy for prevention and treatment of HIV-1 infection
Investigator(s):Guan X, Zhang M
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:12/2012


Project Title:Analysis of the role of ATOH8 and HCC cancer stem cell and somatic cell reprogramming
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:NSFC/RGC Joint Research Scheme
Start Date:01/2013


Project Title:Outstanding Researcher Award 2011-12
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Outstanding Researcher Award
Start Date:01/2013


Project Title:Characterization of CHD1L in regulating hepatocellular carcinoma stemness and self-renewal
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2013


Project Title:Cancer
Investigator(s):Guan X, Chan CLW, Tsao GSW
Department:Clinical Oncology
Source(s) of Funding:Seed Funding for Strategic Research Theme
Start Date:11/2013


Project Title:Characterization of the regulatory roles of CHD1L in stemness and differentiation in hepatocellular carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2014


Project Title:Characterization of the effect of Epstein-Barr Virus encoded BART microRNAs on enhancing tumor-initiating properties and potentially serve as biomarkers in Nasopharyngeal Carcinoma
Investigator(s):Guan X, Kwong DLW
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:01/2014


Project Title:Characterization of tumor suppressive function of HBP21 in hepatocellular carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:06/2014


List of Research Outputs

Chan H.M., Lin C.H., Qi L., Fei J., Li Y., Yong K.J., Liu M., SONG Y., Chow K.K., Ng V.H., Yuan Y.F., Tenen D.G., Guan X. and Chen L., A disrupted RNA editing balance mediated by ADARs (Adenosine DeAminases that act on RNA) in human hepatocellular carcinoma, Gut. 2014, 63(5): 832-843.
Cheung C.C., Chung G.T., Lun S.W., To K.F., Choy K.W., Lau K.M., Siu S.P., Guan X., Ngan R.K., Yip T.T., Busson P., Tsao G.S.W. and Lo K.W., miR-31 is consistently inactivated in EBV-associated nasopharyngeal carcinoma and contributes to its tumorigenesis, Molecular Cancer . 2014, 13(1):184: 184.
Li J., Yang H., Li Y., Liu Y., Chen S., Qi C., Zhang Q., Lan T., He X., Guan X. and Wang L., microRNA-146 up-regulation predicts the prognosis of non-small cell lung cancer by miRNA in situ hybridization, Exp Mol Pathology . 2014, 96(2): 195-199.
Li J.C., Li Y., Ai J.Y., Chen K., Zhu Y.H., Fu L., Qin Y.R., Wang L.J. and Guan X., Podoplanin positive cancer cells at the edge of esophageal squamous cell carcinomas are involved in invasion, Molecular Medicine Reports. 2014, 10(3): 1513-1518.
Li Y., Chen L., Chan H.M. and Guan X., Hepatocellular carcinoma: transcriptome diversity regulated by RNA editing, International Journal of Biochemistry & Cell Biology. 2013, 45(8): 1843-1848.
Li Y., Fu L., Qin Y.R., Zeng T., Zhou J., Zeng Z.L., CHEN J., CAO T., Ban X., Qian C., Cai Z., Xie D., Huang P. and Guan X., Increased expression of EIF5A2, via hypoxia or gene amplification, contributes to metastasis and angiogenesis of esophageal squamous cell carcinoma, Gastroenterology. 2014, 146(7): 1701-1713.
Liu L., Dai Y., CHEN J., Zeng T., Li Y., Chen L., Zhu Y.H., Li J., Li Y., Ma S.K.Y., Xie D., Yuan Y.F. and Guan X., Maelstrom promotes hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition by way of Akt/GSK-3b signaling, Hepatology. 2014, 59: 531-543.
Liu L., Dai Y., CHEN J., Zeng T., Li Y., Chen L., Zhu Y., Li J., Li Y., Xie D., Yuan Y.F. and Guan X., Maelstrom promotes hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition via Akt/GSK-3β/Snail signaling, Hepatology. 2014, 59(2): 531-543.
Liu M., Li Y., Chen L., Chan H.M., SONG Y., Fu L., Zeng T.T., Dai Y.D., Zhu Y.H., Li Y., CHEN J., Yuan Y.F. and Guan X., Allele-specific imbalance of oxidative stress-induced growth inhibitor 1 associates with progression of hepatocellular carcinoma, Gastroenterology. 2014, 146(4): 1084-1096.
Qin Y.R., Qiao J.J., Chan H.M., Zhu Y.H., Liu H., Fei J., Li Y., Guan X. and Chen L., Adenosine-to-inosine RNA editing mediated by ADARs in esophageal squamous cell carcinoma (ESCC), Cancer Research. 2014, 74(3): 840-851.
Tong M., Guan X. and Ma S.K.Y., Functional significance, clinical relevance and therapeutic implications of annexin A3 (ANXA3) in CD133+ cancer stem cells-driven hepatocellular carcinoma, The 4th Asia Pacific Primary Liver Cancer Expert Meeting. 2013.
Wang F.W., Guan X. and Xie D., Roles of eukaryotic initiation factor 5A2 in human cancer, Int J Biol Sci . 2013, 9(10): 1013-1020.
Wong A.M.G., Kong K.L., Chen L., Liu M., Wong A.M.G., Zhu C., Tsang J.W.H. and Guan X., Characterization of CACNA2D3 as a putative tumor suppressor gene in the development and progression of nasopharyngeal carcinoma , International Journal of Cancer. 2013, 133: 2284-2295.
Zhu J., Yu Y., Meng X., Fan Y., Zhang Y., Zhou C., Yue Z., Jin Y., Zhang C., Yu L., Ji W., Jia X., Guan R., Wu J., Yu J., Bai J., Guan X., Wang M., Lee K.Y., Sun W. and Fu S., De novo-generated small palindromes are characteristic of amplicon boundary junction of double minutes, International Journal of Cancer . 2013, 133(4): 797-806.
Zhu Y.H., Liu H., SONG Y., ZHANG L., Zeng T., Qin Y.R., Li L., Liu L., LI J., Zhang B. and Guan X., Downregulation of LGI1 promotes tumor metastasis in esophageal squamous cell carcinoma, Carcinogenesis. 2014, 35(5): 1154-1161.
Zhu Y.H., Yang F., Zhang S.S., Zeng T.T., Xie X. and Guan X., High expression of biglycan is associated with poor prognosis in patients with esophageal squamous cell carcinoma, Int J Clin Exp Pathol . 2013, 6(11): 2497-2505.


Researcher : Guan X.
Project Title:49th Annual Meeting of the American Society of Human Genetics The Association of Chromosome 8p Deletion and Tumor Metastasis in Human Hepatocellular Carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/1999


Project Title:51st Annual Meeting of the American Society of Human Genetics Loss of Tyrosine Aminotransferase may Contribute to the Development of Hepatocellular Carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2001


Project Title:Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:03/2009


Project Title:Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:03/2009


Project Title:Mass spectrometry-based metabolomics for the characterization of cellular metabolic pathways associated with the development of hepatocellular carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:04/2011
Completion Date:03/2014


Project Title:Characterization of tumor suppressive function and mechanism of CHL1 at a frequent deleted region 3p26.3 in esophageal squamous cell carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2011
Completion Date:09/2013


Project Title:The Liver Cancer Genome Project: translating genetic discoveries to clinical benefits
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Theme-based Research Scheme
Start Date:12/2011


Project Title:Characterization of the role of Epstein-Barr virus encoded microRNA BART19-3p in enhancing tumor-initiating properties in nasopharyngeal carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012
Completion Date:05/2014


Project Title:A novel strategy for prevention and treatment of HIV-1 infection
Investigator(s):Guan X, Zhang M
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:12/2012


Project Title:Analysis of the role of ATOH8 and HCC cancer stem cell and somatic cell reprogramming
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:NSFC/RGC Joint Research Scheme
Start Date:01/2013


Project Title:Outstanding Researcher Award 2011-12
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Outstanding Researcher Award
Start Date:01/2013


Project Title:Characterization of CHD1L in regulating hepatocellular carcinoma stemness and self-renewal
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2013


Project Title:Cancer
Investigator(s):Guan X, Chan CLW, Tsao GSW
Department:Clinical Oncology
Source(s) of Funding:Seed Funding for Strategic Research Theme
Start Date:11/2013


Project Title:Characterization of the regulatory roles of CHD1L in stemness and differentiation in hepatocellular carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2014


Project Title:Characterization of the effect of Epstein-Barr Virus encoded BART microRNAs on enhancing tumor-initiating properties and potentially serve as biomarkers in Nasopharyngeal Carcinoma
Investigator(s):Guan X, Kwong DLW
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:01/2014


Project Title:Characterization of tumor suppressive function of HBP21 in hepatocellular carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:06/2014


List of Research Outputs



Researcher : Guan XY
Project Title:49th Annual Meeting of the American Society of Human Genetics The Association of Chromosome 8p Deletion and Tumor Metastasis in Human Hepatocellular Carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/1999


Project Title:51st Annual Meeting of the American Society of Human Genetics Loss of Tyrosine Aminotransferase may Contribute to the Development of Hepatocellular Carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:10/2001


Project Title:Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:03/2009


Project Title:Evaluation of an Oxygen Therapeutic (IKOR-2084) in the Enhancement of Chemotherapy and Radiotherapy in Rodent Cancer Models
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Innovation and Technology Fund Internship Programme
Start Date:03/2009


Project Title:Mass spectrometry-based metabolomics for the characterization of cellular metabolic pathways associated with the development of hepatocellular carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:04/2011
Completion Date:03/2014


Project Title:Characterization of tumor suppressive function and mechanism of CHL1 at a frequent deleted region 3p26.3 in esophageal squamous cell carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2011
Completion Date:09/2013


Project Title:The Liver Cancer Genome Project: translating genetic discoveries to clinical benefits
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Theme-based Research Scheme
Start Date:12/2011


Project Title:Characterization of the role of Epstein-Barr virus encoded microRNA BART19-3p in enhancing tumor-initiating properties in nasopharyngeal carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2012
Completion Date:05/2014


Project Title:A novel strategy for prevention and treatment of HIV-1 infection
Investigator(s):Guan X, Zhang M
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:12/2012


Project Title:Analysis of the role of ATOH8 and HCC cancer stem cell and somatic cell reprogramming
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:NSFC/RGC Joint Research Scheme
Start Date:01/2013


Project Title:Outstanding Researcher Award 2011-12
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Outstanding Researcher Award
Start Date:01/2013


Project Title:Characterization of CHD1L in regulating hepatocellular carcinoma stemness and self-renewal
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2013


Project Title:Cancer
Investigator(s):Guan X, Chan CLW, Tsao GSW
Department:Clinical Oncology
Source(s) of Funding:Seed Funding for Strategic Research Theme
Start Date:11/2013


Project Title:Characterization of the regulatory roles of CHD1L in stemness and differentiation in hepatocellular carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:01/2014


Project Title:Characterization of the effect of Epstein-Barr Virus encoded BART microRNAs on enhancing tumor-initiating properties and potentially serve as biomarkers in Nasopharyngeal Carcinoma
Investigator(s):Guan X, Kwong DLW
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:01/2014


Project Title:Characterization of tumor suppressive function of HBP21 in hepatocellular carcinoma
Investigator(s):Guan X
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:06/2014


List of Research Outputs



Researcher : Ip JCY
List of Research Outputs

Cheung A.K.L., Ip J.C.Y., Lung H.L., Wu J.Z., Tsao G.S.W. and Lung M.L., Polo-like Kinase Inhibitor Ro5203280 Has Potent Antitumor Activity in Nasopharyngeal Carcinoma, Molecular cancer therapeutics. 2013.


Researcher : KAN PQR
List of Research Outputs

KAN P.Q.R., Cheung A.K.L. and Lung M.L., NPC candidate tumor-suppressive ECM protein, LTBP2, mediates its effects via the pleiotropic transcription factor NFkB pathway, 18th Postgraduate Symposium HKU. 2013.
Lung H.L., MAN O.Y., YEUNG M.C., Ko J.M.Y., Cheung A.K.L., LAW W.L., Yu Z., SHUEN W.H., Tung E., Chan S.H.K., Bangarusamy D.K., Cheng Y., YANG X., KAN P.Q.R., PHOON Y.P., CHAN K.C., CHUA D., Kwong D.L.W., Lee A.W.M., Ji M.F. and Lung M.L., SAA1 polymorphisms are associated with variation in antiangiogenic and tumor-suppressive activities in nasopharyngeal carcinoma, Oncogene. 2014.


Researcher : Ko JMY
Project Title:A multigenic SNP association study of DNA repair genes on Chinese esophageal squamous cell carcinoma risk in moderate (Hong Kong) and high risk (Henan) regions
Investigator(s):Ko JMY, Lung ML
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:05/2012
Completion Date:10/2013


Project Title:The 105th Annual Meeting of the American Association for Cancer Research; Germline PALB2 genetic variations of familial esophageal squamous cell carcinoma (ESCC) in Henan, a high risk ESCC region
Investigator(s):Ko JMY
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:04/2014
Completion Date:04/2014


Project Title:Study of alternative splicing of esophageal squamous cell carcinoma through transcriptome analysis in Hong Kong
Investigator(s):Ko JMY, Lung ML
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:06/2014


List of Research Outputs

Cheng Y., Cheung A.K.L., Ko J.M.Y., PHOON Y.P., Chiu P.M., Lo P.H., Waterman M.L. and Lung M.L., Physiological beta-catenin signaling controls self-renewal networks and generation of stem-like cells from nasopharyngeal carcinoma, BMC Cell Biol. BMC, 2013, 14(1): 44.
Ko J.M.Y., Dai W., Wong H.W.E., Kwong D.L.W., Ng W.T., Lee A.W.M., Ngan R.C.K., Yau C.C., Tung S. and Lung M.L., Multigene pathway-based analyses identify nasopharyngeal carcinoma risk associations for cumulative adverse effects of TERT-CLPTM1L and DNA double-strand breaks repair , International Journal of Cancer. 2014, n/a-n/a.
Ko J.M.Y., Li D.W., Law S.Y.K. and Lung M.L., Germline PALB2 genetic variations of familial ESCC in Henan, a high risk ESCC region, 105th American Association of Cancer Research. 2014.
Ko J.M.Y. and Lung M.L., Small Project Funding - “Study of alternative splicing of esophageal squamous cell carcinoma through transcriptome analysis in Hong Kong” HK$46,327, University Research Committee. 2014.
Lung H.L., MAN O.Y., YEUNG M.C., Ko J.M.Y., Cheung A.K.L., LAW W.L., Yu Z., SHUEN W.H., Tung E., Chan S.H.K., Bangarusamy D.K., Cheng Y., YANG X., KAN P.Q.R., PHOON Y.P., CHAN K.C., CHUA D., Kwong D.L.W., Lee A.W.M., Ji M.F. and Lung M.L., SAA1 polymorphisms are associated with variation in antiangiogenic and tumor-suppressive activities in nasopharyngeal carcinoma, Oncogene. 2014.
Lung M.L., Ko J.M.Y., Dai W., Wong H.W.E., Kwong D.L.W., Ng W.T., Lee A., Ngan R.K., Yau C.C. and Tung S., Adverse effects if TERT-CLPTM1L and double-strand breaks repair contribute to risk for NPC, 105th AACR. 2014.


Researcher : Kwong DLW
Project Title:PET/CT scan for early response monitoring and radiation dose escalation in locally advanced nasopharyngeal carcinoma
Investigator(s):Kwong DLW, Khong PL, Lee VHF
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:12/2012


List of Research Outputs

CHAN K.H., Kwong D.L.W., Law G.M., Tam E., Tong A., Lee V. and Ng C.Y., Dosimetric evaluation of four-dimensional dose distributions of CyberKnife and volumetric-modulated arc radiotherapy in stereotactic body lung radiotherapy, Journal of Applied Clinical Medical Physics . 2013, 14(4): 4229.
CHAN K.H., Kwong D.L.W., Tong A., Tam E. and Ng C.Y., Evaluation of dose prediction error and optimization convergence error in four-dimensional inverse planning of robotic stereotactic lung radiotherapy , Journal of Applied Clinical Medical Physics. 2013, Vol. 14 , No. 4: 4270.
CHAN K.H., Kwong D.L.W., Tam E., Tong A. and Ng C.Y., Quantifying variability of intrafractional target motion in stereotactic body radiotherapy for lung cancers , Journal of Applied Clinical Medical Physics. 2013, 14(5): 140-52.
Cheuk I.W., Yip S.P., Kwong D.L.W. and Wu V.W.C., Spandidos Publications 2014, 2014, 2(4): 553-8.
Chung H.P., Lee V.H.F., Tsang R.K.Y., Chan Y.W., Kwong D.L.W., Lam K.O., Sze C.K.H. and Leung T.W., Treatment outcomes of postradiation second head and neck malignancies managed by a multidisciplinary approach , Head & Neck. Wiley Periodicals, Inc., 2014.
D'cruz A., Lin T., Anand A.K., Atmakusuma D., Calaguas M.J., Chitapanarux I., Cho B.C., Goh B.C., Guo Y., Hsieh W.S., Hu C., Kwong D.L.W., Lin J.C., Lou P.J., Lu T., Prabhash K., Sriuranpong V., Tang P., Vu V.V., Wahid I., Ang K.K. and Chan A.T., Consensus recommendations for management of head and neck cancer in Asian countries: A review of international guidelines, Oral Oncology. Elsevier Inc., 2013, 49(9): 872-877.
Fang W.J., Lam K.O., Ng C.Y., Choi C.W., Kwong D.L.W., Zheng S.S. and Lee V.H.F., Manual contouring based volumetric evaluation for colorectal cancer with liver limited metastases: a comparison with RECIST, Asian Pacific Journal of Cancer Prevention. Asian Pacific Organization for Cancer Prevention, 2014, 14(7): 4151-5.
Fang W.J., Lam K.O., Ng C.Y., Choi C.W., Kwong D.L.W., Zheng S.S. and Lee V.H.F., Manual contouring based volumetric evaluation for colorectal cancer with liver limited metastases: a comparison with RECIST, Asian Pacific Journal of cancer prevention: APJCP. Korea, National Cancer Centre, Korea, 2013, 14: 4151.
J C.H.U.N.G., Lee V.H.F., Tsang R.K.Y., Chan Y.W., Kwong D.L.W., Lam K.O., Sze C.K.H. and TW L.E.U.N.G., Treatment outcomes of post-radiation second head and neck malignancies (PRS-SHNM) managed by a multidisciplinary approach, In: Ehab Y. Hanna, Head and Neck. Wiley Periodicals, Inc., A Wiley Company, 2014.
Kam M.K., Wong F.C., Kwong D.L.W., Sze C.K.H. and Lee A.W.M., Current controversies in radiotherapy for nasopharyngeal carcinoma (NPC). , Oral Oncology. 2013.
Ko J.M.Y., Dai W., Wong H.W.E., Kwong D.L.W., Ng W.T., Lee A.W.M., Ngan R.C.K., Yau C.C., Tung S. and Lung M.L., Multigene pathway-based analyses identify nasopharyngeal carcinoma risk associations for cumulative adverse effects of TERT-CLPTM1L and DNA double-strand breaks repair , International Journal of Cancer. 2014, n/a-n/a.
Kwong D.L.W., 1. Multimodality treatment for stomach cancer 2. A case presentation on CA esophagus, 15th Beijing/Hong Kong Medical Exchange – recent advances in cancer medicine, 12-13 October 2013, Changsha, Hunan, PRC. 2013.
Kwong D.L.W., 1. Title of talk: Toward personalized treatment for head and neck cancers: translational developments. 2. Panelist in Challenging cases workshop on Head and Neck Cancer. , Asia-Pacific Oncology Conference, 13-14 July 2013, Bangkok, Thailand. 2013.
Kwong D.L.W., Application of RT in brain tumor, 45th Congress of International Society of Paediatric Oncology (SIOP), 25-28 September 2013, Hong Kong. 2013.
Kwong D.L.W., McGale P., Taylor C., Correa C., Cutter D., Duane F., Ewertz M., Gray R., Mannu G., Peto R., Whelan T., Wang Y., Wang Z. and Darby S., Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trials. , The Lancet . Elsevier Ltd., 2014, 383(9935): 2127-35.
Kwong D.L.W., In: Paediatric tumor, Hong Kong College of Radiologists Intermediate Training Course 2014 (Clinical Oncology). 2014.
Kwong D.L.W., Locally advanced CA larynx in an elderly man treated with radiotherapy and concurrent cetuximab, APAC NECTAR & Merck Serono Oncology Summit, 19-20 July 2013, Seoul, Korea. 2013.
Kwong D.L.W., Radiotherapy and Chemotherapy for Head and Neck Cancers, Continuous Nursing Education Programme, Tung Wah Hospital, Hong Kong. 2014.
Lam K.O., Ho P.Y., Lau K.S., Lee V.H.F., Liu K.Y., Leung T.W. and Kwong D.L.W., Treatment outcomes and implication of complete response on PET scan after first-line cetuximab-xelox in Chinese patients with Kras wild-type metastatic colorectal cancer, APAC-NECTAR Merck Serono Oncology Summit 2013.
Lee V.H.F., Tin P.C., Choy T.S., Lam K.O., Choi C.W., Chung L.P., Tsang J.W.H., Ho P.P., Leung D.K., Ma E.S., Liu J., Shek T.W.H., Kwong D.L.W., Leung T.W. and Wong M.P., Association of Exon 19 and 21 EGFR Mutation Patterns with Treatment Outcome after First-Line Tyrosine Kinase Inhibitor in Metastatic Non-Small-Cell Lung Cancer, In: Lee VH, Tin VP, Choy TS, Lam KO, Choi CW, Chung LP, Tsang JW, Ho PP, Leung DK, Ma ES, Liu J, Shek TW, Kwong DL, Leung TW, Wong MP, J Thorac Oncol. 2013, 8(9):1148-55.
Lee V.H.F. and Kwong D.L.W., Palliative Chemotherapy and Targeted Therapy for Recurrent and Metastatic Nasopharyngeal Carcinoma: Reminiscences and the Future, In: Lee Ho Fun Victor, Kwong Lai Wan Dora, Hong Kong Journal of Radiology. Hong Kong, HKAM Press, 2013, 16: 252.
Lee V.H.F., Kwong D.L.W., Lam K.O., Leung D.K.C., Ho P.P.Y., Cheung Y.T., Wong S.Y., Tsang J.W.H. and Leung T.W., Pre-treatment EBV DNA differentiates different stages of undifferentiated carcinoma of the nasopharynx, European Cancer Congress 2013. Amsterdam, European Cancer Organisation.
Lee V.H.F., Chan W.W., Lee E.Y.P., Choy T.S., Ho P.P., Leung D.K., Lam K.O., Kwong D.L.W., Leung T.W. and Khong P.L., Prognostic Significance of Standardized Uptake Value of Lymph Nodes on Survival for Stage III Non-Small Cell Lung Cancer Treated With Definitive Concurrent Chemoradiotherapy, American Journal of Clinical Oncology . Lippincott Williams & Wilkins, Inc, 2014, Published Ahead-of-Print.
Lee V.H.F., Luk M.Y., Tong C.C., Law W.M., Ng C.Y., Tso W.K., Ma W.H., Liu K.Y., Kwong D.L.W. and Leung T.W., Treatment Outcomes of Patients with Extremely Advanced Inoperable Hepatocellular Carcinoma (HCC) after Yttrium-90 Radioembolization, ESMO 16th World Congress on Gastrointestinal Cancer. European Society for Medical Oncology, 2014.
Lee V.H.F., Ng C.Y., Taw B.T.B., Hung K.N., Lam K.O., Chan W.W.L., Leung D.K.C., Ho P.P.Y., Sze C.K.H., Leung T.W. and Kwong D.L.W., Whole-brain Radiotherapy with Simultaneous Integrated Boost Using Volumetric Modulated Arc Therapy (VMAT) for Patients of Recursive Partitioning Analysis (RPA) Class I and II Suffering from 1-3 Brain Metastases , Hong Kong College of Radiologists 21st Annual Scientific Meeting. Hong Kong, Hong Kong College of Radiologists, 2013.
Liu A.P.Y., Shing M.M.K., Yuen H.L., Li R.C.H., Ling S.C., Luk C.W., Ha S.Y., Li C.K., Kwong D.L.W. and Chan G.C.F., Timing Of Adjuvant Radiotherapy And Treatment Outcome In Childhood Ependymoma, Hong Kong Paediatric Society Annual Scientific Meeting. 2013.
Liu A.P.Y., Shing M.M.K., Yuen H.L., Li R.C.H., Ling S.C., Luk C.W., Ha S.Y., Li C.K., Kwong D.L.W. and Chan G.C.F., Timing of adjuvant radiotherapy and treatment outcome in childhood ependymoma, Joint Annual Scientific Meeting 2013, The HK Paediatric Society and HK Paediatrics Nurses Association Ltd., QEH, 8 September 2013. 53.
Liu A.P.Y., Shing M.M.K., Yuen H.L., Li C.H., Ling S.C., Luk C.W., Ha S.Y., Li C.K., Kwong D.L.W. and Chan G.C.F., Timing of adjuvant radiotherapy and treatment outcome in childhood ependymoma, Pediatric Blood & Cancer. 2014, 61: 606-611.
Lo M.C., YIP T.C., Ngan K.C., Cheng W.W., Law C.K., Chan P.S., Chan K.C., Wong K.C., Wong N.S., Lo K.W., Ng W.T., Lee A.W.M., Tsao G.S.W., Kwong D.L.W., Lung M.L. and Mak N.K., Role of MIF/CXCL8/CXCR2 signaling in the growth of nasopharyngeal carcinoma tumor spheres, Cancer Letters. 2013, 335(1): 81-92.
Lung H.L., MAN O.Y., YEUNG M.C., Ko J.M.Y., Cheung A.K.L., LAW W.L., Yu Z., SHUEN W.H., Tung E., Chan S.H.K., Bangarusamy D.K., Cheng Y., YANG X., KAN P.Q.R., PHOON Y.P., CHAN K.C., CHUA D., Kwong D.L.W., Lee A.W.M., Ji M.F. and Lung M.L., SAA1 polymorphisms are associated with variation in antiangiogenic and tumor-suppressive activities in nasopharyngeal carcinoma, Oncogene. 2014.
Lung M.L., Ko J.M.Y., Dai W., Wong H.W.E., Kwong D.L.W., Ng W.T., Lee A., Ngan R.K., Yau C.C. and Tung S., Adverse effects if TERT-CLPTM1L and double-strand breaks repair contribute to risk for NPC, 105th AACR. 2014.
Shan J., Pow E.H.N., Tsang P.C.S., PERERA R.A.P.M. and Kwong D.L.W., Comparison of two laboratory extraction techniques for the detection of Epstein–Barr virus in the saliva of nasopharyngeal carcinoma patients , Journal of Investigative and Clinical Dentistry . Wiley Publishing Asia Pty Ltd, 2013, 5(2): 104-8.
Sze C.K.H., Lau J., Chan A., Yung S.T., Luk M.Y., Leung T.W., Kwong D.L.W. and Tsang J.W.H., The use of Denosumab for breast cancer patients with bone metastases – experience from a tertiary center, 3rd International Breast Cancer Symposium. 2014.
Tsang J.W.H., Lee V.H.F. and Kwong D.L.W., Novel therapy for nasopharyngeal carcinoma - Where are we, Oral Oncology. Elsevier Ltd., 2014, 50(9): 798-801.
YANG X., Dai W., Szeto C.Y.Y., Cheng Y., Kwong D.L.W. and Lung M.L., Epigenetic markers for early detection of NPC, 18th postgraduate symposium HKU. 2013.


Researcher : LAW WL
List of Research Outputs

Lung H.L., MAN O.Y., YEUNG M.C., Ko J.M.Y., Cheung A.K.L., LAW W.L., Yu Z., SHUEN W.H., Tung E., Chan S.H.K., Bangarusamy D.K., Cheng Y., YANG X., KAN P.Q.R., PHOON Y.P., CHAN K.C., CHUA D., Kwong D.L.W., Lee A.W.M., Ji M.F. and Lung M.L., SAA1 polymorphisms are associated with variation in antiangiogenic and tumor-suppressive activities in nasopharyngeal carcinoma, Oncogene. 2014.


Researcher : LI J
List of Research Outputs

Zhu Y.H., Liu H., SONG Y., ZHANG L., Zeng T., Qin Y.R., Li L., Liu L., LI J., Zhang B. and Guan X., Downregulation of LGI1 promotes tumor metastasis in esophageal squamous cell carcinoma, Carcinogenesis. 2014, 35(5): 1154-1161.


Researcher : Lam KO
Project Title:A prospective study on the predictive and prognostic value of baseline biomarker expressions in locally advanced rectal cancer treated with neoadjuvant chemoradiation using capecitabine
Investigator(s):Lam KO, Kwong DLW, Lee VHF
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:01/2012
Completion Date:07/2014


Project Title:HKU Overseas Fellowship Awards 2013-14
Investigator(s):Lam KO
Department:Clinical Oncology
Source(s) of Funding:HKU Overseas Fellowship Awards
Start Date:08/2013
Completion Date:08/2014


List of Research Outputs

Cheng A.L., Li J., Vaid A.K., Ma B., Teh C.S., Ahn J.B., Bello M., Charoentum C., Chen L.T., de Lima Lopes Jr G., Ho G.F., Kong H.L., Lam K.O., Liu T.S., Park Y.S., Sriuranpong V., Sudoyo A.W., Wang J.Y., Zhang J., Zhang S.Z., Ciardiello F., Kohne C.H., Shaw M. and Kim T.W., Adaptatioin Of International Guidelines For Metastatic Colorectal Cancer: An Asian Consensus, Clinical Colorectal Cancer. 2014.
Chung H.P., Lee V.H.F., Tsang R.K.Y., Chan Y.W., Kwong D.L.W., Lam K.O., Sze C.K.H. and Leung T.W., Treatment outcomes of postradiation second head and neck malignancies managed by a multidisciplinary approach , Head & Neck. Wiley Periodicals, Inc., 2014.
Fang W.J., Lam K.O., Ng C.Y., Choi C.W., Kwong D.L.W., Zheng S.S. and Lee V.H.F., Manual contouring based volumetric evaluation for colorectal cancer with liver limited metastases: a comparison with RECIST, Asian Pacific Journal of Cancer Prevention. Asian Pacific Organization for Cancer Prevention, 2014, 14(7): 4151-5.
Fang W.J., Lam K.O., Ng C.Y., Choi C.W., Kwong D.L.W., Zheng S.S. and Lee V.H.F., Manual contouring based volumetric evaluation for colorectal cancer with liver limited metastases: a comparison with RECIST, Asian Pacific Journal of cancer prevention: APJCP. Korea, National Cancer Centre, Korea, 2013, 14: 4151.
J C.H.U.N.G., Lee V.H.F., Tsang R.K.Y., Chan Y.W., Kwong D.L.W., Lam K.O., Sze C.K.H. and TW L.E.U.N.G., Treatment outcomes of post-radiation second head and neck malignancies (PRS-SHNM) managed by a multidisciplinary approach, In: Ehab Y. Hanna, Head and Neck. Wiley Periodicals, Inc., A Wiley Company, 2014.
Lai V., LI X., Lee V.H.F., Lam K.O., Fong D.Y.T., Huang B., Chan Q. and Khong P.L., Nasopharyngeal carcinoma: comparison of diffusion and perfusion characteristics between different tumour stages using intravoxel incoherent motion MR imaging., European Radiology. 2014, 24(1): 176-183.
Lai V., Lee V.H.F., Lam K.O., Sze C.K.H., Huang B. and Khong P.L., Utility of Intravoxel Incoherent Motion MR Imaging in Characterisation of Nasopharyngeal Carcinoma, Nasopharyngeal Carcinoma AoE IAB. 2013.
Lam K.O., Anti-EGFR Monoclonal Antibodies in Metastatic Colorectal Cancer - Will the Pendulum Swing, 5th Joint Scientific Meeting of The Royal College of Radiologists & Hong Kong College of Radiologists and 21st Annual Scientific Meeting of Hong Kong College of Radiologists. 2013.
Lam K.O., Bevacizumab in the Elderly QMH Experience Sharing, Safety in the Management of Colorectal Cancer: Oncologist & Surgeon Expert Forum. 2014.
Lam K.O., Controversies in Metastatic Colorectal Cancer, Multi-specialty Medical Mega Conference Fourth Round. 2014.
Lam K.O., From complexity to simplicity: applying the best level of evidence in mCRC, The Hong Kong College of Radiologists and The Society of Clinical Oncology. 2013.
Lam K.O., From complexity to simplicity: best level of evidence for metastatic colorectal cancer., In: WCW Chu, Hong Kong Journal of Radiology. HKAM Press, 2013, 16(Supp): S9-16.
Lam K.O., Management of Colorectal Cancer: Clinical Oncologist’s Perspective, CRC Case Management Enhancement Training Program by Hospital Authority. 2014.
Lam K.O., Maximizing treatment exposure in metastatic colorectal cancer, Oncology Tribune. Oncology Tribune, 2013.
Lam K.O., ONcologiC Management of Upper Gastro-intestinal Cancers, Post-registration Certificate Course in Oncology Nursing 2013-14. 2014.
Lam K.O., The HKU Overseas Fellowship Award, The University of Hong Kong. 2013.
Lam K.O., Ho P.Y., Lau K.S., Lee V.H.F., Liu K.Y., Leung T.W. and Kwong D.L.W., Treatment outcomes and implication of complete response on PET scan after first-line cetuximab-xelox in Chinese patients with Kras wild-type metastatic colorectal cancer, APAC-NECTAR Merck Serono Oncology Summit 2013.
Lee V.H.F., Tin P.C., Choy T.S., Lam K.O., Choi C.W., Chung L.P., Tsang J.W.H., Ho P.P., Leung D.K., Ma E.S., Liu J., Shek T.W.H., Kwong D.L.W., Leung T.W. and Wong M.P., Association of Exon 19 and 21 EGFR Mutation Patterns with Treatment Outcome after First-Line Tyrosine Kinase Inhibitor in Metastatic Non-Small-Cell Lung Cancer, In: Lee VH, Tin VP, Choy TS, Lam KO, Choi CW, Chung LP, Tsang JW, Ho PP, Leung DK, Ma ES, Liu J, Shek TW, Kwong DL, Leung TW, Wong MP, J Thorac Oncol. 2013, 8(9):1148-55.
Lee V.H.F., Tin P.C., Choy T.S., Lam K.O., Choi C.W., Chung L.P., Tsang J.W.H., Ho P.P.Y., Leung D.K.C. and Ma E.S.K., Association of Exon 19 and 21 EGFR Mutation Patterns with Treatment Outcome after First-Line Tyrosine Kinase Inhibitor in Metastatic Non–Small-Cell Lung Cancer, Journal of Thoracic Oncology. 2013, 8: 1148-1155.
Lee V.H.F., Kwong D.L.W., Lam K.O., Leung D.K.C., Ho P.P.Y., Cheung Y.T., Wong S.Y., Tsang J.W.H. and Leung T.W., Pre-treatment EBV DNA differentiates different stages of undifferentiated carcinoma of the nasopharynx, European Cancer Congress 2013. Amsterdam, European Cancer Organisation.
Lee V.H.F., Chan W.W., Lee E.Y.P., Choy T.S., Ho P.P., Leung D.K., Lam K.O., Kwong D.L.W., Leung T.W. and Khong P.L., Prognostic Significance of Standardized Uptake Value of Lymph Nodes on Survival for Stage III Non-Small Cell Lung Cancer Treated With Definitive Concurrent Chemoradiotherapy, American Journal of Clinical Oncology . Lippincott Williams & Wilkins, Inc, 2014, Published Ahead-of-Print.
Lee V.H.F., Ng C.Y., Taw B.T.B., Hung K.N., Lam K.O., Chan W.W.L., Leung D.K.C., Ho P.P.Y., Sze C.K.H., Leung T.W. and Kwong D.L.W., Whole-brain Radiotherapy with Simultaneous Integrated Boost Using Volumetric Modulated Arc Therapy (VMAT) for Patients of Recursive Partitioning Analysis (RPA) Class I and II Suffering from 1-3 Brain Metastases , Hong Kong College of Radiologists 21st Annual Scientific Meeting. Hong Kong, Hong Kong College of Radiologists, 2013.


Researcher : Lee AWM
List of Research Outputs

Kam M.K., Wong F.C., Kwong D.L.W., Sze C.K.H. and Lee A.W.M., Current controversies in radiotherapy for nasopharyngeal carcinoma (NPC). , Oral Oncology. 2013.
Lo M.C., YIP T.C., Ngan K.C., Cheng W.W., Law C.K., Chan P.S., Chan K.C., Wong K.C., Wong N.S., Lo K.W., Ng W.T., Lee A.W.M., Tsao G.S.W., Kwong D.L.W., Lung M.L. and Mak N.K., Role of MIF/CXCL8/CXCR2 signaling in the growth of nasopharyngeal carcinoma tumor spheres, Cancer Letters. 2013, 335(1): 81-92.


Researcher : Lee VHF
Project Title:A retrospective analysis of genetic aberrations as predictors of relapse and survival outcomes in completely resected stage III adenocarcinoma of colon after the use of oxaliplatin-based regimen as adjuvant chemotherapy
Investigator(s):Lee VHF, Chua DTT, Kwong DLW
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:02/2009


Project Title:Complementary EBV DNA testing for the poor and sick patents diagnosed to have nasopharyngeal carcinoma
Investigator(s):Lee VHF, Kwong DLW
Department:Clinical Oncology
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:09/2010


Project Title:A prospective study on the anatomical and physiological changes of carotid arteries by doppler ultrasonography after Intensity Modulated Radiation Therapy (IMRT) for untreated nasopharyngeal carcinoma (NPC)
Investigator(s):Lee VHF, Wong CS, Kwong DLW
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:03/2011
Completion Date:02/2014


Project Title:Host, Salivary, Virulent and Molecular Attributes to the Development of Oral Candidiasis During Intensity Modulated Radiation Therapy (IMRT) for Nasopharyngeal Carcinoma (NPC) – A Prospective Study
Investigator(s):Lee VHF, Kwong DLW
Department:Clinical Oncology
Source(s) of Funding:Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:01/2012


Project Title:Complimentary EBV DNA testing for the poor and sick patients diagnosed to have nasopharyngeal carcinoma
Investigator(s):Lee VHF, Kwong DLW
Department:Clinical Oncology
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:02/2012


Project Title:Identification of epithelial stem cells and factors predicting recovery of mucositis after intensity modulated radiation therapy (IMRT) for patients with nasopharyngeal carcinoma (NPC)
Investigator(s):Lee VHF, Guan X, Kwong DLW, Lam KO
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:06/2013


Project Title:Development of Cancer Registry of Human Papilloma Virus (HPV)-associated Oral and Oropharyngeal Cancers in Hong Kong and its Correlation with Survival Outcomes
Investigator(s):Lee VHF, Kwong DLW, Lam KO, Sze CKH
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:06/2014


List of Research Outputs

Chan W.L., Lee V.H.F., Choy T.S. and Leung T.W., Pineal Parenchymal Tumor of Intermediate Differentiation: two cases treated with adjuvant radiotherapy, 20th Hong Kong International Cancer Congress. Hong Kong, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 2013.
Chan W.L., Ng C.Y., Law W.M., Lee V.H.F., Wan K.Y. and Leung T.W., Volumetric-modulated Arc Therapy in Differentiated Thyroid Cancer: a comparison with Intensity-modulated Radiotherapy, World Congress of Thyroid Cancer 2013. Toronto, World Congress of Thyroid Cancer.
Chung H.P., Lee V.H.F., Tsang R.K.Y., Chan Y.W., Kwong D.L.W., Lam K.O., Sze C.K.H. and Leung T.W., Treatment outcomes of postradiation second head and neck malignancies managed by a multidisciplinary approach , Head & Neck. Wiley Periodicals, Inc., 2014.
Fang W.J., Lam K.O., Ng C.Y., Choi C.W., Kwong D.L.W., Zheng S.S. and Lee V.H.F., Manual contouring based volumetric evaluation for colorectal cancer with liver limited metastases: a comparison with RECIST, Asian Pacific Journal of Cancer Prevention. Asian Pacific Organization for Cancer Prevention, 2014, 14(7): 4151-5.
Fang W.J., Lam K.O., Ng C.Y., Choi C.W., Kwong D.L.W., Zheng S.S. and Lee V.H.F., Manual contouring based volumetric evaluation for colorectal cancer with liver limited metastases: a comparison with RECIST, Asian Pacific Journal of cancer prevention: APJCP. Korea, National Cancer Centre, Korea, 2013, 14: 4151.
J C.H.U.N.G., Lee V.H.F., Tsang R.K.Y., Chan Y.W., Kwong D.L.W., Lam K.O., Sze C.K.H. and TW L.E.U.N.G., Treatment outcomes of post-radiation second head and neck malignancies (PRS-SHNM) managed by a multidisciplinary approach, In: Ehab Y. Hanna, Head and Neck. Wiley Periodicals, Inc., A Wiley Company, 2014.
Lai V., LI X., Lee V.H.F., Lam K.O., Fong D.Y.T., Huang B., Chan Q. and Khong P.L., Nasopharyngeal carcinoma: comparison of diffusion and perfusion characteristics between different tumour stages using intravoxel incoherent motion MR imaging., European Radiology. 2014, 24(1): 176-183.
Lai V., Lee V.H.F., Lam K.O., Sze C.K.H., Huang B. and Khong P.L., Utility of Intravoxel Incoherent Motion MR Imaging in Characterisation of Nasopharyngeal Carcinoma, Nasopharyngeal Carcinoma AoE IAB. 2013.
Lam K.O., Ho P.Y., Lau K.S., Lee V.H.F., Liu K.Y., Leung T.W. and Kwong D.L.W., Treatment outcomes and implication of complete response on PET scan after first-line cetuximab-xelox in Chinese patients with Kras wild-type metastatic colorectal cancer, APAC-NECTAR Merck Serono Oncology Summit 2013.
Lee V.H.F., Adjuvant Therapy for Parotid Cancer, ENT course 2013 - Parotid, Palate & Paranasal Sinus Surgery. Hong Kong, Department of Surgery, The University of Hong Kong, 2013.
Lee V.H.F., Annual General Meeting 2013, Palliative and Maintenance Therapy for Metastatic Non-small-cell Lung Cancer. Macua, Macau Chest Diseases and Tuberculosis Association, 2013.
Lee V.H.F., Tin P.C., Choy T.S., Lam K.O., Choi C.W., Chung L.P., Tsang J.W.H., Ho P.P., Leung D.K., Ma E.S., Liu J., Shek T.W.H., Kwong D.L.W., Leung T.W. and Wong M.P., Association of Exon 19 and 21 EGFR Mutation Patterns with Treatment Outcome after First-Line Tyrosine Kinase Inhibitor in Metastatic Non-Small-Cell Lung Cancer, In: Lee VH, Tin VP, Choy TS, Lam KO, Choi CW, Chung LP, Tsang JW, Ho PP, Leung DK, Ma ES, Liu J, Shek TW, Kwong DL, Leung TW, Wong MP, J Thorac Oncol. 2013, 8(9):1148-55.
Lee V.H.F., Tin P.C., Choy T.S., Lam K.O., Choi C.W., Chung L.P., Tsang J.W.H., Ho P.P.Y., Leung D.K.C. and Ma E.S.K., Association of Exon 19 and 21 EGFR Mutation Patterns with Treatment Outcome after First-Line Tyrosine Kinase Inhibitor in Metastatic Non–Small-Cell Lung Cancer, Journal of Thoracic Oncology. 2013, 8: 1148-1155.
Lee V.H.F., Case sharing on the use of cetuximab for oesophageal cancer, 2nd Oncology Summit. Merck Pharmaceutical (HK) Limited, 2013.
Lee V.H.F., Distinguished Young Fellow of Hong Kong Academy of Medicine, Hong Kong Academy of Medicine. 2013.
Lee V.H.F., Editor of Modern Chemotherapy, In: Shamim Ahmad, Seung Joon Baek , Jeon‐Hor Chen, James CS Chim, Massimo Donadelli, Erin M. Dunbar, Ashkan Emadi, Mehdi Hamadani, Christopher Allan Hamm,, Modern Chemotherapy. Scientific Research, 2013.
Lee V.H.F., Modern Chemotherapy. 2013.
Lee V.H.F., Nasopharyngeal Cancer: signs/ symptoms, investigation, treatment & prevention, Nasopharyngeal Cancer: signs/ symptoms, investigation, treatment & prevention. Hong Kong, Hong Kong Anti-Cancer Society, 2013.
Lee V.H.F. and Kwong D.L.W., Palliative Chemotherapy and Targeted Therapy for Recurrent and Metastatic Nasopharyngeal Carcinoma: Reminiscences and the Future, In: Lee Ho Fun Victor, Kwong Lai Wan Dora, Hong Kong Journal of Radiology. Hong Kong, HKAM Press, 2013, 16: 252.
Lee V.H.F., Kwong D.L.W., Lam K.O., Leung D.K.C., Ho P.P.Y., Cheung Y.T., Wong S.Y., Tsang J.W.H. and Leung T.W., Pre-treatment EBV DNA differentiates different stages of undifferentiated carcinoma of the nasopharynx, European Cancer Congress 2013. Amsterdam, European Cancer Organisation.
Lee V.H.F., Chan W.W., Lee E.Y.P., Choy T.S., Ho P.P., Leung D.K., Lam K.O., Kwong D.L.W., Leung T.W. and Khong P.L., Prognostic Significance of Standardized Uptake Value of Lymph Nodes on Survival for Stage III Non-Small Cell Lung Cancer Treated With Definitive Concurrent Chemoradiotherapy, American Journal of Clinical Oncology . Lippincott Williams & Wilkins, Inc, 2014, Published Ahead-of-Print.
Lee V.H.F., Luk M.Y., Tong C.C., Law W.M., Ng C.Y., Tso W.K., Ma W.H., Liu K.Y., Kwong D.L.W. and Leung T.W., Treatment Outcomes of Patients with Extremely Advanced Inoperable Hepatocellular Carcinoma (HCC) after Yttrium-90 Radioembolization, ESMO 16th World Congress on Gastrointestinal Cancer. European Society for Medical Oncology, 2014.
Lee V.H.F., Ng C.Y., Taw B.T.B., Hung K.N., Lam K.O., Chan W.W.L., Leung D.K.C., Ho P.P.Y., Sze C.K.H., Leung T.W. and Kwong D.L.W., Whole-brain Radiotherapy with Simultaneous Integrated Boost Using Volumetric Modulated Arc Therapy (VMAT) for Patients of Recursive Partitioning Analysis (RPA) Class I and II Suffering from 1-3 Brain Metastases , Hong Kong College of Radiologists 21st Annual Scientific Meeting. Hong Kong, Hong Kong College of Radiologists, 2013.
Lee V.W., Schwander B. and Lee V.H.F., Effectiveness and cost-effectiveness of erlotinib versus gefitinib in first-line treatment of epidermal growth factor receptor-activating mutation-positive non-small-cell lung cancer patients in Hong Kong., Hong Kong Medical Journal. Hong Kong, HKAM Press, 2013.
Leung D.K.C., Lee V.H.F., Liu K.Y., Luk M.Y., Law W.M., Tso W.K., Wong K.K., Wong K.K., Ma V.W.H., Ng C.Y., Poon R.T.P., Tong C.C. and Leung T.W., Radioembolization with yttrium-90 microspheres for inoperable advanced hepatocellular carcinoma (HCC), Hong Kong College of Radiologists 21st Annual Scientific Meeting. Hong Kong, Hong Kong College of Radiologists, 2013.
Ma L., Wang D.D., Huang Y., Wong M.P., Lee V.H.F. and Yan H., Decoding the EGFR mutation-induced drug resistance in lung cancer treatment by local surface geometric properties, In: Ma L, Wang DD, Huang Y, Wong MP, Lee VH and Yan H. , Comput Biol Med . 2014.
Ng C.Y., Law W.M., Lee V.H.F., Ma W. and Leung T.W., Feasibility of 90Y Bremsstrahlung scan to determine SIRT patient dose, 99th Scientific and Annual Meeting, The Radiological Society of North America. USA, The Radiological Society of North America, 2013.
Ng C.Y., Lee V.H.F., Law W.M., Liu K.Y., Ma V.W., Tso W.K. and Leung T.W., Patient dosimetry for 90Y selective internal radiation treatment based on 90Y PET imaging, Journal of Applied Clinical Medical Physics. USA, MULTIMED, 2013, 14: 212.
Tsang J.W.H., Lee V.H.F. and Kwong D.L.W., Novel therapy for nasopharyngeal carcinoma - Where are we, Oral Oncology. Elsevier Ltd., 2014, 50(9): 798-801.
Wang D.D., Zhou W., Yan H., Wong M.P. and Lee V.H.F., Personalized prediction of EGFR mutation-induced drug resistance in lung cancer, In: Debby D. Wang, Weiqiang Zhou, Hong Yan, Maria Wong & Victor Lee, Scientific Reports. 2013, 3:2855.
Wong M.P. and Lee V.H.F., 治療肺癌新契機, In: 王碧, 李浩勳, 育醫造才:探索醫學世界 第三册, 2014, 71.
Wu Y.L., Lee J.S., Thongprasert S., Yu C.J., Zhang L., Ladrera G., Srimuninnimit V., Sriuranpong V., Sandoval-Tan J., Zhu Y., Liao M., Zhou C., Pan H., Lee V.H.F., Chen Y.M., Sun Y., Margono B., Fuerte F., Chang G.C., Seetalarom K., Wang J., Cheng C.K., Syahruddin E., Qian X., Ho J.C.M., Kurnianda J., Liu H.E., Jin K., Truman M., Bara I. and Mok T., Intercalated combination of chemotherapy and erlotinib for patients with advanced stage non-small-lung cancer (FASTACT-2): a randomised, double-blind trial, Lancet Oncology. Science Direct, 2013, 14: 777-786.


Researcher : Leung TW
List of Research Outputs

Chan W.L., Lee V.H.F., Choy T.S. and Leung T.W., Pineal Parenchymal Tumor of Intermediate Differentiation: two cases treated with adjuvant radiotherapy, 20th Hong Kong International Cancer Congress. Hong Kong, Li Ka Shing Faculty of Medicine, The University of Hong Kong, 2013.
Chan W.L., Ng C.Y., Law W.M., Lee V.H.F., Wan K.Y. and Leung T.W., Volumetric-modulated Arc Therapy in Differentiated Thyroid Cancer: a comparison with Intensity-modulated Radiotherapy, World Congress of Thyroid Cancer 2013. Toronto, World Congress of Thyroid Cancer.
Chung H.P., Lee V.H.F., Tsang R.K.Y., Chan Y.W., Kwong D.L.W., Lam K.O., Sze C.K.H. and Leung T.W., Treatment outcomes of postradiation second head and neck malignancies managed by a multidisciplinary approach , Head & Neck. Wiley Periodicals, Inc., 2014.
Lam K.O., Ho P.Y., Lau K.S., Lee V.H.F., Liu K.Y., Leung T.W. and Kwong D.L.W., Treatment outcomes and implication of complete response on PET scan after first-line cetuximab-xelox in Chinese patients with Kras wild-type metastatic colorectal cancer, APAC-NECTAR Merck Serono Oncology Summit 2013.
Lee V.H.F., Tin P.C., Choy T.S., Lam K.O., Choi C.W., Chung L.P., Tsang J.W.H., Ho P.P., Leung D.K., Ma E.S., Liu J., Shek T.W.H., Kwong D.L.W., Leung T.W. and Wong M.P., Association of Exon 19 and 21 EGFR Mutation Patterns with Treatment Outcome after First-Line Tyrosine Kinase Inhibitor in Metastatic Non-Small-Cell Lung Cancer, In: Lee VH, Tin VP, Choy TS, Lam KO, Choi CW, Chung LP, Tsang JW, Ho PP, Leung DK, Ma ES, Liu J, Shek TW, Kwong DL, Leung TW, Wong MP, J Thorac Oncol. 2013, 8(9):1148-55.
Lee V.H.F., Kwong D.L.W., Lam K.O., Leung D.K.C., Ho P.P.Y., Cheung Y.T., Wong S.Y., Tsang J.W.H. and Leung T.W., Pre-treatment EBV DNA differentiates different stages of undifferentiated carcinoma of the nasopharynx, European Cancer Congress 2013. Amsterdam, European Cancer Organisation.
Lee V.H.F., Chan W.W., Lee E.Y.P., Choy T.S., Ho P.P., Leung D.K., Lam K.O., Kwong D.L.W., Leung T.W. and Khong P.L., Prognostic Significance of Standardized Uptake Value of Lymph Nodes on Survival for Stage III Non-Small Cell Lung Cancer Treated With Definitive Concurrent Chemoradiotherapy, American Journal of Clinical Oncology . Lippincott Williams & Wilkins, Inc, 2014, Published Ahead-of-Print.
Lee V.H.F., Luk M.Y., Tong C.C., Law W.M., Ng C.Y., Tso W.K., Ma W.H., Liu K.Y., Kwong D.L.W. and Leung T.W., Treatment Outcomes of Patients with Extremely Advanced Inoperable Hepatocellular Carcinoma (HCC) after Yttrium-90 Radioembolization, ESMO 16th World Congress on Gastrointestinal Cancer. European Society for Medical Oncology, 2014.
Lee V.H.F., Ng C.Y., Taw B.T.B., Hung K.N., Lam K.O., Chan W.W.L., Leung D.K.C., Ho P.P.Y., Sze C.K.H., Leung T.W. and Kwong D.L.W., Whole-brain Radiotherapy with Simultaneous Integrated Boost Using Volumetric Modulated Arc Therapy (VMAT) for Patients of Recursive Partitioning Analysis (RPA) Class I and II Suffering from 1-3 Brain Metastases , Hong Kong College of Radiologists 21st Annual Scientific Meeting. Hong Kong, Hong Kong College of Radiologists, 2013.
Leung D.K.C., Lee V.H.F., Liu K.Y., Luk M.Y., Law W.M., Tso W.K., Wong K.K., Wong K.K., Ma V.W.H., Ng C.Y., Poon R.T.P., Tong C.C. and Leung T.W., Radioembolization with yttrium-90 microspheres for inoperable advanced hepatocellular carcinoma (HCC), Hong Kong College of Radiologists 21st Annual Scientific Meeting. Hong Kong, Hong Kong College of Radiologists, 2013.
Ng C.Y., Law W.M., Lee V.H.F., Ma W. and Leung T.W., Feasibility of 90Y Bremsstrahlung scan to determine SIRT patient dose, 99th Scientific and Annual Meeting, The Radiological Society of North America. USA, The Radiological Society of North America, 2013.
Ng C.Y., Lee V.H.F., Law W.M., Liu K.Y., Ma V.W., Tso W.K. and Leung T.W., Patient dosimetry for 90Y selective internal radiation treatment based on 90Y PET imaging, Journal of Applied Clinical Medical Physics. USA, MULTIMED, 2013, 14: 212.
Sze C.K.H., Lau J., Chan A., Yung S.T., Luk M.Y., Leung T.W., Kwong D.L.W. and Tsang J.W.H., The use of Denosumab for breast cancer patients with bone metastases – experience from a tertiary center, 3rd International Breast Cancer Symposium. 2014.


Researcher : Li Y
Project Title:Identification of the novel transforming GLI3–MRPL48 fusion gene in non-small-cell lung cancer.
Investigator(s):Li Y, Guan X
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:03/2014


List of Research Outputs

Chan H.M., Lin C.H., Qi L., Fei J., Li Y., Yong K.J., Liu M., SONG Y., Chow K.K., Ng V.H., Yuan Y.F., Tenen D.G., Guan X. and Chen L., A disrupted RNA editing balance mediated by ADARs (Adenosine DeAminases that act on RNA) in human hepatocellular carcinoma, Gut. 2014, 63(5): 832-843.
Li Y., 2013 Young Scientist Award (Life Science Panel), Hong Kong Institution of Science. 2013.
Li Y., Dr KP Stephen Chang Gold Medal 2011/2012, The University of Hong Kong. 2013.
Li Y., Chen L., Chan H.M. and Guan X., Hepatocellular carcinoma: transcriptome diversity regulated by RNA editing, International Journal of Biochemistry & Cell Biology. 2013, 45(8): 1843-1848.
Li Y., Li Ka Shing Prize, 2011/2012, The University of Hong Kong. 2013.
Liu L., Dai Y., CHEN J., Zeng T., Li Y., Chen L., Zhu Y.H., Li J., Li Y., Ma S.K.Y., Xie D., Yuan Y.F. and Guan X., Maelstrom promotes hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition by way of Akt/GSK-3b signaling, Hepatology. 2014, 59: 531-543.
Liu L., Dai Y., CHEN J., Zeng T., Li Y., Chen L., Zhu Y., Li J., Li Y., Xie D., Yuan Y.F. and Guan X., Maelstrom promotes hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition via Akt/GSK-3β/Snail signaling, Hepatology. 2014, 59(2): 531-543.
Liu M., Li Y., Chen L., Chan H.M., SONG Y., Fu L., Zeng T.T., Dai Y.D., Zhu Y.H. and Li Y., Allele-Specific Imbalance of Oxidative Stress-Induced Growth Inhibitor 1 Associates With Progression of Hepatocellular Carcinoma, Gastroenterology. 2014, 146: 1084-1096.e5.
Liu M., Li Y., Chen L., Chan H.M., SONG Y., Fu L., Zeng T.T., Dai Y.D., Zhu Y.H., Li Y., CHEN J., Yuan Y.F. and Guan X., Allele-specific imbalance of oxidative stress-induced growth inhibitor 1 associates with progression of hepatocellular carcinoma, Gastroenterology. 2014, 146(4): 1084-1096.
Qin Y.R., Qiao J.J., Chan H.M., Zhu Y.H., Liu H., Fei J., Li Y., Guan X. and Chen L., Adenosine-to-inosine RNA editing mediated by ADARs in esophageal squamous cell carcinoma (ESCC), Cancer Research. 2014, 74(3): 840-851.


Researcher : Liu KY
List of Research Outputs

Lam K.O., Ho P.Y., Lau K.S., Lee V.H.F., Liu K.Y., Leung T.W. and Kwong D.L.W., Treatment outcomes and implication of complete response on PET scan after first-line cetuximab-xelox in Chinese patients with Kras wild-type metastatic colorectal cancer, APAC-NECTAR Merck Serono Oncology Summit 2013.
Lee V.H.F., Luk M.Y., Tong C.C., Law W.M., Ng C.Y., Tso W.K., Ma W.H., Liu K.Y., Kwong D.L.W. and Leung T.W., Treatment Outcomes of Patients with Extremely Advanced Inoperable Hepatocellular Carcinoma (HCC) after Yttrium-90 Radioembolization, ESMO 16th World Congress on Gastrointestinal Cancer. European Society for Medical Oncology, 2014.
Leung D.K.C., Lee V.H.F., Liu K.Y., Luk M.Y., Law W.M., Tso W.K., Wong K.K., Wong K.K., Ma V.W.H., Ng C.Y., Poon R.T.P., Tong C.C. and Leung T.W., Radioembolization with yttrium-90 microspheres for inoperable advanced hepatocellular carcinoma (HCC), Hong Kong College of Radiologists 21st Annual Scientific Meeting. Hong Kong, Hong Kong College of Radiologists, 2013.
Ng C.Y., Lee V.H.F., Law W.M., Liu K.Y., Ma V.W., Tso W.K. and Leung T.W., Patient dosimetry for 90Y selective internal radiation treatment based on 90Y PET imaging, Journal of Applied Clinical Medical Physics. USA, MULTIMED, 2013, 14: 212.


Researcher : Liu M
Project Title:The 11th international conference of the Asian Clinical Oncology Society ; CHD1L ASSOCIATES WITH TUMOR DIFFERENCIATION AND MIGHT BE A NOVEL THERAPEUTIC TARGET IN HEPATOCELLULAR CARCINOMA
Investigator(s):Liu M
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:05/2014
Completion Date:05/2014


List of Research Outputs

Chan H.M., Lin C.H., Qi L., Fei J., Li Y., Yong K.J., Liu M., SONG Y., Chow K.K., Ng V.H., Yuan Y.F., Tenen D.G., Guan X. and Chen L., A disrupted RNA editing balance mediated by ADARs (Adenosine DeAminases that act on RNA) in human hepatocellular carcinoma, Gut. 2014, 63(5): 832-843.
Liu M., Li Y., Chen L., Chan H.M., SONG Y., Fu L., Zeng T.T., Dai Y.D., Zhu Y.H. and Li Y., Allele-Specific Imbalance of Oxidative Stress-Induced Growth Inhibitor 1 Associates With Progression of Hepatocellular Carcinoma, Gastroenterology. 2014, 146: 1084-1096.e5.
Liu M., Li Y., Chen L., Chan H.M., SONG Y., Fu L., Zeng T.T., Dai Y.D., Zhu Y.H., Li Y., CHEN J., Yuan Y.F. and Guan X., Allele-specific imbalance of oxidative stress-induced growth inhibitor 1 associates with progression of hepatocellular carcinoma, Gastroenterology. 2014, 146(4): 1084-1096.
Wong A.M.G., Kong K.L., Chen L., Liu M., Wong A.M.G., Zhu C., Tsang J.W.H. and Guan X., Characterization of CACNA2D3 as a putative tumor suppressor gene in the development and progression of nasopharyngeal carcinoma , International Journal of Cancer. 2013, 133: 2284-2295.


Researcher : Luk MY
List of Research Outputs

Ho R.T.H., Kwan T.T.C., Cheung K.M., CHAN K.P.C., Lo H.Y.P., Yip P.S.F., Luk M.Y. and Chan C.L.W., Association of fatigue with perceived stress in Chinese women with early stage breast cancer awaiting adjuvant radiotherapy, Stress and Health. 2013, online first.
Lee V.H.F., Luk M.Y., Tong C.C., Law W.M., Ng C.Y., Tso W.K., Ma W.H., Liu K.Y., Kwong D.L.W. and Leung T.W., Treatment Outcomes of Patients with Extremely Advanced Inoperable Hepatocellular Carcinoma (HCC) after Yttrium-90 Radioembolization, ESMO 16th World Congress on Gastrointestinal Cancer. European Society for Medical Oncology, 2014.
Leung D.K.C., Lee V.H.F., Liu K.Y., Luk M.Y., Law W.M., Tso W.K., Wong K.K., Wong K.K., Ma V.W.H., Ng C.Y., Poon R.T.P., Tong C.C. and Leung T.W., Radioembolization with yttrium-90 microspheres for inoperable advanced hepatocellular carcinoma (HCC), Hong Kong College of Radiologists 21st Annual Scientific Meeting. Hong Kong, Hong Kong College of Radiologists, 2013.
Sze C.K.H., Lau J., Chan A., Yung S.T., Luk M.Y., Leung T.W., Kwong D.L.W. and Tsang J.W.H., The use of Denosumab for breast cancer patients with bone metastases – experience from a tertiary center, 3rd International Breast Cancer Symposium. 2014.


Researcher : Lung HL
Project Title:Investigation of the X-linked candidate genes which escape the X-inactivation in nasopharyngeal carcinoma
Investigator(s):Lung HL, Lung ML
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2012
Completion Date:11/2013


Project Title:Investigation of the sixth base, 5-hydroxymethylcytosine, in nasopharyngeal carcinoma
Investigator(s):Lung HL
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:04/2013


Project Title:The serum amyloid A1 (SAA1) Polymorphisms as Risk Factors in Esophageal Squamous Cell Carcinoma
Investigator(s):Lung HL, Lung ML, Law SYK
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:11/2013


Project Title:American Association for Cancer Research Annual Meeting 2014; The role of the tumor suppressor gene THY1 in suppression of epithelial-mesenchymal transition (EMT) in nasopharyngeal carcinoma
Investigator(s):Lung HL
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:04/2014


Project Title:Establishment of human nasopharyngeal carcinoma in 3D invasion and angiogenesis organotypic culture to study hypoxia-induced tumor invasion and angiogenesis
Investigator(s):Lung HL
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2014


List of Research Outputs

Cheung A.K.L., Ip J.C.Y., Lung H.L., Wu J.Z., Tsao G.S.W. and Lung M.L., Polo-like Kinase Inhibitor Ro5203280 Has Potent Antitumor Activity in Nasopharyngeal Carcinoma, Molecular cancer therapeutics. 2013.
Lung H.L., Associate editor, Bioprotocol. www.bio-protocol.org, 2014.
Lung H.L., Reviewer, Bioprotocol for manuscript 2. 2013.
Lung H.L., MAN O.Y., YEUNG M.C., Ko J.M.Y., Cheung A.K.L., LAW W.L., Yu Z., SHUEN W.H., Tung E., Chan S.H.K., Bangarusamy D.K., Cheng Y., YANG X., KAN P.Q.R., PHOON Y.P., CHAN K.C., CHUA D., Kwong D.L.W., Lee A.W.M., Ji M.F. and Lung M.L., SAA1 polymorphisms are associated with variation in antiangiogenic and tumor-suppressive activities in nasopharyngeal carcinoma, Oncogene. 2014.
Lung H.L. and Lung M.L., The role of the tumor suppressor gene THY1 in suppression of EMT in NPC, 105th AACR. 2014.
MAN O.Y., Lung M.L. and Lung H.L., Differential angiogenic roles of SAA1 as a tumor suppressor gene in ESCC, 105th AACR. 2014.
MAN O.Y., Lung M.L. and Lung H.L., Regulation of EMT by SAA1 is dependent on integrin in ESCC, 15th International Biennial Congress of the Metastasis Research Society. 2014.
MAN O.Y., Lung M.L. and Lung H.L., The roles of SAA1 as a tumor suppressor gene in esophageal squamous cell carcinoma, 18th Postgraduate Symposium HKU. 2013.


Researcher : Lung ML
Project Title:Candidate tumor suppressor gene, DUSP6, involvement in esophageal and nasopharyngeal carcinomas
Investigator(s):Lung ML
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2009


Project Title:Centre for Nasopharyngeal Carcinoma Research
Investigator(s):Lung ML, Chen H, Chiang AKS, Chua DTT, Khong PL, Kwong DLW, Guan X, Tsao GSW, Wu EX
Department:Clinical Oncology
Source(s) of Funding:Areas of Excellence Scheme
Start Date:01/2010


Project Title:Role of DNAJB6 epithelial-mesenchymal transition in esophageal squamous cell carcinoma tumorigenesis and metastasis
Investigator(s):Lung ML
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2011


Project Title:Identifying germline alterations associated with familial esophageal squamous cell carcinoma
Investigator(s):Lung ML, Ko JMY
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:03/2013
Completion Date:02/2014


Project Title:Elucidating the functional role of a metastasis-associated extracellular matrix gene, ECM1, in esophageal cancer
Investigator(s):Lung ML
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:11/2013


Project Title:Elucidating the genetic basis for early-age onset nasopharyngeal carcinoma in Hong Kong
Investigator(s):Lung ML, Sham PC, Yang W, Cherny SS, Chiang AKS
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:11/2013


Project Title:American Association for Cancer Research Annual Meeting 2014; Adverse effects of TERT-CLPTM1L and double-strand breaks repair contribute to risk for NPC
Investigator(s):Lung ML
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:04/2014
Completion Date:04/2014


List of Research Outputs

Cheng Y., PHOON Y.P. and Lung M.L., Inhibition of both physiological and aberrant Wnt/beta-catenin signaling activities in nasopharyngeal carcinoma, American Association for Cancer Research Annual Meeting 2014.
Cheng Y., Cheung A.K.L., Ko J.M.Y., PHOON Y.P., Chiu P.M., Lo P.H., Waterman M.L. and Lung M.L., Physiological beta-catenin signaling controls self-renewal networks and generation of stem-like cells from nasopharyngeal carcinoma, BMC Cell Biol. BMC, 2013, 14(1): 44.
Cheng Y. and Lung M.L., inhibition of both physiological and aberrant Wnt/b-catenin signaling activities associated with stemness in NPC, 105th American Association of Cancer Research. 2014.
Cheung A.K.L., Ip J.C.Y., Lung H.L., Wu J.Z., Tsao G.S.W. and Lung M.L., Polo-like Kinase Inhibitor Ro5203280 Has Potent Antitumor Activity in Nasopharyngeal Carcinoma, Molecular cancer therapeutics. 2013.
Chow J.P., Man W.Y., Mao M., Chen H., Cheung M.F.F., Nicholls J.M., Tsao G.S.W., Lung M.L. and Poon R.Y., Poly(ADP-ribose) polymerase 1 is overexpressed in nasopharyngeal carcinoma and its inhibition enhances radiotherapy, Molecular Cancer Therapeutics. 2013, 12(11): 2517-28.
Dai W. and Lung M.L., Small Project Funding - “Pilot Study for Deciphering Methylome of Nasopharyngeal Carcinoma (NPC)” HK$51,732, University Research Committee. 2014.
KAN P.Q.R., Cheung A.K.L. and Lung M.L., NPC candidate tumor-suppressive ECM protein, LTBP2, mediates its effects via the pleiotropic transcription factor NFkB pathway, 18th Postgraduate Symposium HKU. 2013.
Ko J.M.Y., Dai W., Wong H.W.E., Kwong D.L.W., Ng W.T., Lee A.W.M., Ngan R.C.K., Yau C.C., Tung S. and Lung M.L., Multigene pathway-based analyses identify nasopharyngeal carcinoma risk associations for cumulative adverse effects of TERT-CLPTM1L and DNA double-strand breaks repair , International Journal of Cancer. 2014, n/a-n/a.
Ko J.M.Y., Li D.W., Law S.Y.K. and Lung M.L., Germline PALB2 genetic variations of familial ESCC in Henan, a high risk ESCC region, 105th American Association of Cancer Research. 2014.
Ko J.M.Y. and Lung M.L., Small Project Funding - “Study of alternative splicing of esophageal squamous cell carcinoma through transcriptome analysis in Hong Kong” HK$46,327, University Research Committee. 2014.
Lo M.C., YIP T.C., Ngan K.C., Cheng W.W., Law C.K., Chan P.S., Chan K.C., Wong K.C., Wong N.S., Lo K.W., Ng W.T., Lee A.W.M., Tsao G.S.W., Kwong D.L.W., Lung M.L. and Mak N.K., Role of MIF/CXCL8/CXCR2 signaling in the growth of nasopharyngeal carcinoma tumor spheres, Cancer Letters. 2013, 335(1): 81-92.
Lung H.L., MAN O.Y., YEUNG M.C., Ko J.M.Y., Cheung A.K.L., LAW W.L., Yu Z., SHUEN W.H., Tung E., Chan S.H.K., Bangarusamy D.K., Cheng Y., YANG X., KAN P.Q.R., PHOON Y.P., CHAN K.C., CHUA D., Kwong D.L.W., Lee A.W.M., Ji M.F. and Lung M.L., SAA1 polymorphisms are associated with variation in antiangiogenic and tumor-suppressive activities in nasopharyngeal carcinoma, Oncogene. 2014.
Lung H.L. and Lung M.L., The role of the tumor suppressor gene THY1 in suppression of EMT in NPC, 105th AACR. 2014.
Lung M.L., Advanced Study Institute, Croucher Foundation. 2014.
Lung M.L., Advances in Nasopharyngeal Carcinoma Studies, Croucher Foundation Advanced Study Institute. 2014.
Lung M.L., Ko J.M.Y., Dai W., Wong H.W.E., Kwong D.L.W., Ng W.T., Lee A., Ngan R.K., Yau C.C. and Tung S., Adverse effects if TERT-CLPTM1L and double-strand breaks repair contribute to risk for NPC, 105th AACR. 2014.
Lung M.L., Center for NPC Research: NPC diagnostics, Hong Kong Biotech Horizons, Translational Medicine: Promising Research in Cancer Therapies and Diagnostics. 2013.
Lung M.L., Deciphering the molecular genetic basis of esophageal cancers: identity by descent approach, 2013.
Lung M.L., GRF Research Grant 2014 - "Secretory NID2, a basement membrane protein facilitating cell adhesion, migration, and metastasis in human cancers" HK$1,122,210, Research Grants Council. 2014.
Lung M.L., Research Grant 2013-2015 - “Genetic studies of NPC” $2,155,000 , Hong Kong Cancer Fund. 2014.
Lung M.L., Research Grant 2013-2015 - “The SAA1 polymorphism vs risk factors in ESCC” $785,624 (Co-investigator) , Health Medical Research Fund. 2014.
Lung M.L., Research Grant 2013-2015 - “Elucidating the genetic basis for early-age onset NPC in Hong Kong” $1,000,000 , Health Medical Research Fund. 2014.
Lung M.L., Research Grant 2013-2015 - “Genomic studies of esophageal squamous cell carcinoma familial genetic susceptibility and diagnostic biomarkers” HK$800,000 , Asian Cancer Research Fund. 2014.
Lung M.L., Research Grant 2014-2015 - “Genomic studies of esophageal squamous cell carcinoma familial genetic susceptibility and diagnostic biomarkers” HK$345,000, Asian Cancer Research Fund. 2014.
MAN O.Y., Lung M.L. and Lung H.L., Differential angiogenic roles of SAA1 as a tumor suppressor gene in ESCC, 105th AACR. 2014.
MAN O.Y., Lung M.L. and Lung H.L., Regulation of EMT by SAA1 is dependent on integrin in ESCC, 15th International Biennial Congress of the Metastasis Research Society. 2014.
MAN O.Y., Lung M.L. and Lung H.L., The roles of SAA1 as a tumor suppressor gene in esophageal squamous cell carcinoma, 18th Postgraduate Symposium HKU. 2013.
NG H.Y. and Lung M.L., Characterization of the tumor suppressive role of DESC1 in esophageal squamous cell carcinoma, 18th Postgraduate Symposium HKU . 2013.
PHOON Y.P., Cheung A.K.L. and Lung M.L., The tumor suppressive role of IKBb, a NFkB inhibitor, in NPC, 18th Postgraduate symposium HKU. 2013.
Szeto C.Y.Y., Lin C., Choi S.C., Yip T.T., Ngan R.K., Tsao G.S.W. and Lung M.L., Integrated mRNA and microRNA transcriptome sequencing characterizes sequence variants and mRNA – microRNA regulatory network in nasopharyngeal carcinoma model systems. , FEBS Open Biology. 2014, 10: 1016.
YANG X., Dai W., Szeto C.Y.Y., Cheng Y., Kwong D.L.W. and Lung M.L., Epigenetic markers for early detection of NPC, 18th postgraduate symposium HKU. 2013.
Yu Z., WONG C.L., Chan K.W. and Lung M.L., DNAJB6 as tumor suppressor in ESCC, 105th AACR. 2014.


Researcher : MAN OY
List of Research Outputs

Lung H.L., MAN O.Y., YEUNG M.C., Ko J.M.Y., Cheung A.K.L., LAW W.L., Yu Z., SHUEN W.H., Tung E., Chan S.H.K., Bangarusamy D.K., Cheng Y., YANG X., KAN P.Q.R., PHOON Y.P., CHAN K.C., CHUA D., Kwong D.L.W., Lee A.W.M., Ji M.F. and Lung M.L., SAA1 polymorphisms are associated with variation in antiangiogenic and tumor-suppressive activities in nasopharyngeal carcinoma, Oncogene. 2014.
MAN O.Y., Lung M.L. and Lung H.L., Differential angiogenic roles of SAA1 as a tumor suppressor gene in ESCC, 105th AACR. 2014.
MAN O.Y., Lung M.L. and Lung H.L., Regulation of EMT by SAA1 is dependent on integrin in ESCC, 15th International Biennial Congress of the Metastasis Research Society. 2014.
MAN O.Y., Lung M.L. and Lung H.L., The roles of SAA1 as a tumor suppressor gene in esophageal squamous cell carcinoma, 18th Postgraduate Symposium HKU. 2013.


Researcher : Ma SKY
Project Title:Functional and molecular characterization of TP53INP1 as a novel metastasis suppressor in hepatocellular carcinoma
Investigator(s):Ma SKY
Department:Pathology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:03/2012
Completion Date:02/2014


Project Title:Centre for MicroRNA Study - Basic Research and Clinical Potentials in Cancer
Investigator(s):Ma SKY, Wong AST
Department:Pathology
Source(s) of Funding:Collaborative Research Fund (CRF) - Group Research Project
Start Date:06/2012


Project Title:Characterization and clinical evaluation of the metastasis-suppressing function of TP53INP1 in hepatocellular carcinoma
Investigator(s):Ma SKY
Department:Pathology
Source(s) of Funding:General Research Fund (GRF)
Start Date:10/2012


Project Title:Hepatitis B virus promotes hepatocarcinogenesis through induction of CD133+ cancer stem cells/tumor-initiating cells
Investigator(s):Ma SKY, Guan X
Department:Clinical Oncology
Source(s) of Funding:Health and Medical Research Fund - Full Grant
Start Date:01/2013


Project Title:Epigenetic modulation of CD133+ liver cancer stem cells by chromatin-modifying enzymes
Investigator(s):Ma SKY
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:05/2013
Completion Date:04/2014


Project Title:Significance of Annexin A3 in CD133+ Cancer-Initiating Cells-Driven Hepatocellular Carcinoma
Investigator(s):Ma SKY, Chan KW
Department:Clinical Oncology
Source(s) of Funding:General Research Fund (GRF)
Start Date:12/2013


Project Title:Outstanding Young Researcher Award 2012-13
Investigator(s):Ma SKY
Department:Anatomy
Source(s) of Funding:Outstanding Young Researcher Award
Start Date:01/2014


Project Title:American Association for Cancer Research Annual Meeting 2014; Annexin A3 is a therapeutic target for CD133+ liver cancer stem cells
Investigator(s):Ma SKY
Department:Anatomy
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:04/2014
Completion Date:04/2014


Project Title:A multidisciplinary study on hepatic cancer stem cells
Investigator(s):Ma SKY
Department:Anatomy
Source(s) of Funding:Croucher Innovation Awards
Start Date:04/2014


Project Title:The use of anti-annexin A3 monoclonal antibody for the treatment of liver cancer
Investigator(s):Ma SKY
Department:Anatomy
Source(s) of Funding:Seed Funding Programme for Applied Research
Start Date:05/2014


Project Title:miR-1246 and Wnt/β-catenin interaction in the control of CD133+ liver cancer stem cells driven hepatocellular carcinoma
Investigator(s):Ma SKY
Department:Anatomy
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:06/2014


List of Research Outputs

Ma S.K.Y., CD133 hepatic cancer stem cells, The 4th Asia Pacific Primary Liver Cancer Expert Meeting, Busan, Korea. 2013.
Ma S.K.Y., Role of liver cancer stem cells in HCC metastasis, The 4th Asia Pacific Primary Liver Cancer Expert Meeting, Busan, Korea. 2013.
Tong M., Guan X. and Ma S.K.Y., Functional significance, clinical relevance and therapeutic implications of annexin A3 (ANXA3) in CD133+ cancer stem cells-driven hepatocellular carcinoma, The 4th Asia Pacific Primary Liver Cancer Expert Meeting. 2013.


Researcher : NG HY
List of Research Outputs

NG H.Y. and Lung M.L., Characterization of the tumor suppressive role of DESC1 in esophageal squamous cell carcinoma, 18th Postgraduate Symposium HKU . 2013.


Researcher : Ng CY
List of Research Outputs

CHAN K.H., Kwong D.L.W., Law G.M., Tam E., Tong A., Lee V. and Ng C.Y., Dosimetric evaluation of four-dimensional dose distributions of CyberKnife and volumetric-modulated arc radiotherapy in stereotactic body lung radiotherapy, Journal of Applied Clinical Medical Physics . 2013, 14(4): 4229.
CHAN K.H., Kwong D.L.W., Tong A., Tam E. and Ng C.Y., Evaluation of dose prediction error and optimization convergence error in four-dimensional inverse planning of robotic stereotactic lung radiotherapy , Journal of Applied Clinical Medical Physics. 2013, Vol. 14 , No. 4: 4270.
CHAN K.H., Kwong D.L.W., Tam E., Tong A. and Ng C.Y., Quantifying variability of intrafractional target motion in stereotactic body radiotherapy for lung cancers , Journal of Applied Clinical Medical Physics. 2013, 14(5): 140-52.
Chan W.L., Ng C.Y., Law W.M., Lee V.H.F., Wan K.Y. and Leung T.W., Volumetric-modulated Arc Therapy in Differentiated Thyroid Cancer: a comparison with Intensity-modulated Radiotherapy, World Congress of Thyroid Cancer 2013. Toronto, World Congress of Thyroid Cancer.
Fang W.J., Lam K.O., Ng C.Y., Choi C.W., Kwong D.L.W., Zheng S.S. and Lee V.H.F., Manual contouring based volumetric evaluation for colorectal cancer with liver limited metastases: a comparison with RECIST, Asian Pacific Journal of Cancer Prevention. Asian Pacific Organization for Cancer Prevention, 2014, 14(7): 4151-5.
Fang W.J., Lam K.O., Ng C.Y., Choi C.W., Kwong D.L.W., Zheng S.S. and Lee V.H.F., Manual contouring based volumetric evaluation for colorectal cancer with liver limited metastases: a comparison with RECIST, Asian Pacific Journal of cancer prevention: APJCP. Korea, National Cancer Centre, Korea, 2013, 14: 4151.
Lee V.H.F., Luk M.Y., Tong C.C., Law W.M., Ng C.Y., Tso W.K., Ma W.H., Liu K.Y., Kwong D.L.W. and Leung T.W., Treatment Outcomes of Patients with Extremely Advanced Inoperable Hepatocellular Carcinoma (HCC) after Yttrium-90 Radioembolization, ESMO 16th World Congress on Gastrointestinal Cancer. European Society for Medical Oncology, 2014.
Lee V.H.F., Ng C.Y., Taw B.T.B., Hung K.N., Lam K.O., Chan W.W.L., Leung D.K.C., Ho P.P.Y., Sze C.K.H., Leung T.W. and Kwong D.L.W., Whole-brain Radiotherapy with Simultaneous Integrated Boost Using Volumetric Modulated Arc Therapy (VMAT) for Patients of Recursive Partitioning Analysis (RPA) Class I and II Suffering from 1-3 Brain Metastases , Hong Kong College of Radiologists 21st Annual Scientific Meeting. Hong Kong, Hong Kong College of Radiologists, 2013.
Leung D.K.C., Lee V.H.F., Liu K.Y., Luk M.Y., Law W.M., Tso W.K., Wong K.K., Wong K.K., Ma V.W.H., Ng C.Y., Poon R.T.P., Tong C.C. and Leung T.W., Radioembolization with yttrium-90 microspheres for inoperable advanced hepatocellular carcinoma (HCC), Hong Kong College of Radiologists 21st Annual Scientific Meeting. Hong Kong, Hong Kong College of Radiologists, 2013.
Ng C.Y., Law W.M., Lee V.H.F., Ma W. and Leung T.W., Feasibility of 90Y Bremsstrahlung scan to determine SIRT patient dose, 99th Scientific and Annual Meeting, The Radiological Society of North America. USA, The Radiological Society of North America, 2013.
Ng C.Y., Lee V.H.F., Law W.M., Liu K.Y., Ma V.W., Tso W.K. and Leung T.W., Patient dosimetry for 90Y selective internal radiation treatment based on 90Y PET imaging, Journal of Applied Clinical Medical Physics. USA, MULTIMED, 2013, 14: 212.


Researcher : Ng WT
List of Research Outputs

Lee A.W.M., Ng W.T., Chan L.L., Hung W.M., Chan C.C., Sze C.K.H., Chan O.S.H., Chang A.T. and Yeung M.W.R., Evolution of treatment for nasopharyngeal cancer--success and setback in the intensity-modulated radiotherapy era, In: Jens Overgaard, Radiother Oncol.. Radiother Oncol., 2014, 110: 377-384.
Sze C.K.H., Chan L.K.L., Ng W.T., Hung W.M.A., Lee C.H.M., Chang T.Y.A., Chan O.S.H., Cheung F.Y., Yeung M.W.R. and Lee A.W.M., The prognostic significance of masticator space involvement in nasopharyngeal carcinoma. , 咀嚼肌间隙侵犯对鼻咽癌分期影响的重要意义, The 9th Pan-Pearl-River Area Congress of Radiation Oncology. 第九届泛珠会议, 2014.


Researcher : PHOON YP
List of Research Outputs

Cheng Y., PHOON Y.P. and Lung M.L., Inhibition of both physiological and aberrant Wnt/beta-catenin signaling activities in nasopharyngeal carcinoma, American Association for Cancer Research Annual Meeting 2014.
Cheng Y., Cheung A.K.L., Ko J.M.Y., PHOON Y.P., Chiu P.M., Lo P.H., Waterman M.L. and Lung M.L., Physiological beta-catenin signaling controls self-renewal networks and generation of stem-like cells from nasopharyngeal carcinoma, BMC Cell Biol. BMC, 2013, 14(1): 44.
Lung H.L., MAN O.Y., YEUNG M.C., Ko J.M.Y., Cheung A.K.L., LAW W.L., Yu Z., SHUEN W.H., Tung E., Chan S.H.K., Bangarusamy D.K., Cheng Y., YANG X., KAN P.Q.R., PHOON Y.P., CHAN K.C., CHUA D., Kwong D.L.W., Lee A.W.M., Ji M.F. and Lung M.L., SAA1 polymorphisms are associated with variation in antiangiogenic and tumor-suppressive activities in nasopharyngeal carcinoma, Oncogene. 2014.
PHOON Y.P., Cheung A.K.L. and Lung M.L., The tumor suppressive role of IKBb, a NFkB inhibitor, in NPC, 18th Postgraduate symposium HKU. 2013.


Researcher : SHUEN WH
List of Research Outputs

Lung H.L., MAN O.Y., YEUNG M.C., Ko J.M.Y., Cheung A.K.L., LAW W.L., Yu Z., SHUEN W.H., Tung E., Chan S.H.K., Bangarusamy D.K., Cheng Y., YANG X., KAN P.Q.R., PHOON Y.P., CHAN K.C., CHUA D., Kwong D.L.W., Lee A.W.M., Ji M.F. and Lung M.L., SAA1 polymorphisms are associated with variation in antiangiogenic and tumor-suppressive activities in nasopharyngeal carcinoma, Oncogene. 2014.


Researcher : SONG Y
List of Research Outputs

Chan H.M., Lin C.H., Qi L., Fei J., Li Y., Yong K.J., Liu M., SONG Y., Chow K.K., Ng V.H., Yuan Y.F., Tenen D.G., Guan X. and Chen L., A disrupted RNA editing balance mediated by ADARs (Adenosine DeAminases that act on RNA) in human hepatocellular carcinoma, Gut. 2014, 63(5): 832-843.
Liu M., Li Y., Chen L., Chan H.M., SONG Y., Fu L., Zeng T.T., Dai Y.D., Zhu Y.H. and Li Y., Allele-Specific Imbalance of Oxidative Stress-Induced Growth Inhibitor 1 Associates With Progression of Hepatocellular Carcinoma, Gastroenterology. 2014, 146: 1084-1096.e5.
Liu M., Li Y., Chen L., Chan H.M., SONG Y., Fu L., Zeng T.T., Dai Y.D., Zhu Y.H., Li Y., CHEN J., Yuan Y.F. and Guan X., Allele-specific imbalance of oxidative stress-induced growth inhibitor 1 associates with progression of hepatocellular carcinoma, Gastroenterology. 2014, 146(4): 1084-1096.
Zhu Y.H., Liu H., SONG Y., ZHANG L., Zeng T., Qin Y.R., Li L., Liu L., LI J., Zhang B. and Guan X., Downregulation of LGI1 promotes tumor metastasis in esophageal squamous cell carcinoma, Carcinogenesis. 2014, 35(5): 1154-1161.


Researcher : Sham JST
List of Research Outputs

Chan J.S.M., Ho R.T.H., Wang C., Yuan L.P., Sham J.S.T. and Chan C.L.W., Effects of Qigong Exercise on Fatigue, Anxiety, and Depressive Symptoms of Patients with Chronic Fatigue Syndrome-Like Illness: A Randomized Controlled Trial, Evidence-Based Complementary and Alternative Medicine. 2013, 2013: Article ID 485341, 8 pages.


Researcher : Sze CKH
Project Title:Feasibility and prognostic impact of DNA repair gene profiling by PCR array in locally advanced nasopharyngeal carcinoma treated with radiotherapy alone or in conjunction with chemoradiotherapy.
Investigator(s):Sze CKH, Kwong DLW, Lung ML, Lung HL, Lee AWM, Lee VHF, Lam KO
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:11/2013


List of Research Outputs

Chung H.P., Lee V.H.F., Tsang R.K.Y., Chan Y.W., Kwong D.L.W., Lam K.O., Sze C.K.H. and Leung T.W., Treatment outcomes of postradiation second head and neck malignancies managed by a multidisciplinary approach , Head & Neck. Wiley Periodicals, Inc., 2014.
J C.H.U.N.G., Lee V.H.F., Tsang R.K.Y., Chan Y.W., Kwong D.L.W., Lam K.O., Sze C.K.H. and TW L.E.U.N.G., Treatment outcomes of post-radiation second head and neck malignancies (PRS-SHNM) managed by a multidisciplinary approach, In: Ehab Y. Hanna, Head and Neck. Wiley Periodicals, Inc., A Wiley Company, 2014.
Kam M.K., Wong F.C., Kwong D.L.W., Sze C.K.H. and Lee A.W.M., Current controversies in radiotherapy for nasopharyngeal carcinoma (NPC). , Oral Oncology. 2013.
Lai V., Lee V.H.F., Lam K.O., Sze C.K.H., Huang B. and Khong P.L., Utility of Intravoxel Incoherent Motion MR Imaging in Characterisation of Nasopharyngeal Carcinoma, Nasopharyngeal Carcinoma AoE IAB. 2013.
Lee A.W.M., Ng W.T., Chan L.L., Hung W.M., Chan C.C., Sze C.K.H., Chan O.S.H., Chang A.T. and Yeung M.W.R., Evolution of treatment for nasopharyngeal cancer--success and setback in the intensity-modulated radiotherapy era, In: Jens Overgaard, Radiother Oncol.. Radiother Oncol., 2014, 110: 377-384.
Lee V.H.F., Ng C.Y., Taw B.T.B., Hung K.N., Lam K.O., Chan W.W.L., Leung D.K.C., Ho P.P.Y., Sze C.K.H., Leung T.W. and Kwong D.L.W., Whole-brain Radiotherapy with Simultaneous Integrated Boost Using Volumetric Modulated Arc Therapy (VMAT) for Patients of Recursive Partitioning Analysis (RPA) Class I and II Suffering from 1-3 Brain Metastases , Hong Kong College of Radiologists 21st Annual Scientific Meeting. Hong Kong, Hong Kong College of Radiologists, 2013.
Sze C.K.H., Chan L.K.L., Ng W.T., Hung W.M.A., Lee C.H.M., Chang T.Y.A., Chan O.S.H., Cheung F.Y., Yeung M.W.R. and Lee A.W.M., The prognostic significance of masticator space involvement in nasopharyngeal carcinoma. , 咀嚼肌间隙侵犯对鼻咽癌分期影响的重要意义, The 9th Pan-Pearl-River Area Congress of Radiation Oncology. 第九届泛珠会议, 2014.
Sze C.K.H., Lau J., Chan A., Yung S.T., Luk M.Y., Leung T.W., Kwong D.L.W. and Tsang J.W.H., The use of Denosumab for breast cancer patients with bone metastases – experience from a tertiary center, 3rd International Breast Cancer Symposium. 2014.


Researcher : Szeto CYY
List of Research Outputs

Szeto C.Y.Y., Lin C., Choi S.C., Yip T.T., Ngan R.K., Tsao G.S.W. and Lung M.L., Integrated mRNA and microRNA transcriptome sequencing characterizes sequence variants and mRNA – microRNA regulatory network in nasopharyngeal carcinoma model systems. , FEBS Open Biology. 2014, 10: 1016.
YANG X., Dai W., Szeto C.Y.Y., Cheng Y., Kwong D.L.W. and Lung M.L., Epigenetic markers for early detection of NPC, 18th postgraduate symposium HKU. 2013.


Researcher : Tong CC
List of Research Outputs

Lee V.H.F., Luk M.Y., Tong C.C., Law W.M., Ng C.Y., Tso W.K., Ma W.H., Liu K.Y., Kwong D.L.W. and Leung T.W., Treatment Outcomes of Patients with Extremely Advanced Inoperable Hepatocellular Carcinoma (HCC) after Yttrium-90 Radioembolization, ESMO 16th World Congress on Gastrointestinal Cancer. European Society for Medical Oncology, 2014.
Leung D.K.C., Lee V.H.F., Liu K.Y., Luk M.Y., Law W.M., Tso W.K., Wong K.K., Wong K.K., Ma V.W.H., Ng C.Y., Poon R.T.P., Tong C.C. and Leung T.W., Radioembolization with yttrium-90 microspheres for inoperable advanced hepatocellular carcinoma (HCC), Hong Kong College of Radiologists 21st Annual Scientific Meeting. Hong Kong, Hong Kong College of Radiologists, 2013.


Researcher : Tong M
List of Research Outputs

Tong M., Guan X. and Ma S.K.Y., Functional significance, clinical relevance and therapeutic implications of annexin A3 (ANXA3) in CD133+ cancer stem cells-driven hepatocellular carcinoma, The 4th Asia Pacific Primary Liver Cancer Expert Meeting. 2013.


Researcher : Tsang JWH
Project Title:Breast Cancer Awareness, Spectrum of Breast Cancer with Particular Reference to Triple Negative Breast Cancer in the Hong Kong Chinese Population
Investigator(s):Tsang JWH, Chua DTT, Kwong A, Khoo US, Lam WWT
Department:Clinical Oncology
Source(s) of Funding:Seed Funding Programme for Basic Research
Start Date:10/2008


Project Title:General Awareness and Attitudes towards Cancer Clinical Trials among Cancer Patients in Hong Kong.
Investigator(s):Tsang JWH, Yung ST, Lam WWT
Department:Clinical Oncology
Source(s) of Funding:Small Project Funding
Start Date:04/2011


Project Title:Training Oncology Interns in Patient-centred Communication
Investigator(s):Tsang JWH, Lam WWT, Fielding R
Department:Clinical Oncology
Source(s) of Funding:Hong Kong Cancer Fund - General Award
Start Date:04/2011


Project Title:Study of the OncotypeDx 21-gene assay and its impact on the treatment decision making process among Hong Kong Chinese breast cancer patients
Investigator(s):Tsang JWH, Khoo US
Department:Clinical Oncology
Source(s) of Funding:S.K. Yee Medical Foundation - General Award
Start Date:08/2012


List of Research Outputs

Chan L.C., Chen J.Y. and Tsang J.W.H., Outstanding Teaching Award (Team), The University of Hong Kong. 2013.
Chen J.Y., Tsang J.W.H. and Chan L.C., Suffering, dying, grief and loss: Medical students’ photo-reflections., 10th International Conference on Grief and Bereavement in Contemporary Society, Hong Kong,. 2014.
Khongkow M., Olmos Y., Gong C., Gomes A.R., Monteiro L.J., Yague E., Cavaco T.B., Khongkow P., Man E.P., Laohasinnarong S., Koo C.Y., Harada-Shoji N., Tsang J.W.H., Coombes R.C., Schwer B., Khoo U.S. and Lam E.W., SIRT6 modulates paclitaxel and epirubicin resistance and survival in breast cancer, Carcinogenesis. 2013, 34(7): 1476-86.
Lam W.W.T., Soong I., Yau T.K., Wong K.Y., Tsang J.W.H., Yeo W., Suen J., Ho W.M., Sze W.K., Ng A.W., Kwong A., Suen T.K.D. and Fielding R., The evolution of psychological distress trajectories in women diagnosed with advanced breast cancer: a longitudinal study , Psycho-oncology . 2013, 22(12): 2831-9.
Lam W.W.T., Tsang J.W.H., Yeo W., Suen J., Ho W.M., Yau T.K., Soong I., Wong K.Y., Kwong A., Suen T.K.D., Sze W.K., Ng W.Y., Girgis A. and Fielding R., The evolution of supportive care needs trajectories in women with advanced breast cancer during the 12 months following diagnosis , Support Care in Cancer. 2014, 22(3): 635-44.
Lee V.H.F., Tin P.C., Choy T.S., Lam K.O., Choi C.W., Chung L.P., Tsang J.W.H., Ho P.P., Leung D.K., Ma E.S., Liu J., Shek T.W.H., Kwong D.L.W., Leung T.W. and Wong M.P., Association of Exon 19 and 21 EGFR Mutation Patterns with Treatment Outcome after First-Line Tyrosine Kinase Inhibitor in Metastatic Non-Small-Cell Lung Cancer, In: Lee VH, Tin VP, Choy TS, Lam KO, Choi CW, Chung LP, Tsang JW, Ho PP, Leung DK, Ma ES, Liu J, Shek TW, Kwong DL, Leung TW, Wong MP, J Thorac Oncol. 2013, 8(9):1148-55.
Lee V.H.F., Tin P.C., Choy T.S., Lam K.O., Choi C.W., Chung L.P., Tsang J.W.H., Ho P.P.Y., Leung D.K.C. and Ma E.S.K., Association of Exon 19 and 21 EGFR Mutation Patterns with Treatment Outcome after First-Line Tyrosine Kinase Inhibitor in Metastatic Non–Small-Cell Lung Cancer, Journal of Thoracic Oncology. 2013, 8: 1148-1155.
Lee V.H.F., Kwong D.L.W., Lam K.O., Leung D.K.C., Ho P.P.Y., Cheung Y.T., Wong S.Y., Tsang J.W.H. and Leung T.W., Pre-treatment EBV DNA differentiates different stages of undifferentiated carcinoma of the nasopharynx, European Cancer Congress 2013. Amsterdam, European Cancer Organisation.
Sze C.K.H., Lau J., Chan A., Yung S.T., Luk M.Y., Leung T.W., Kwong D.L.W. and Tsang J.W.H., The use of Denosumab for breast cancer patients with bone metastases – experience from a tertiary center, 3rd International Breast Cancer Symposium. 2014.
Tsang J.W.H., Lee V.H.F. and Kwong D.L.W., Novel therapy for nasopharyngeal carcinoma - Where are we, Oral Oncology. Elsevier Ltd., 2014, 50(9): 798-801.
Wong A.M.G., Kong K.L., Chen L., Liu M., Wong A.M.G., Zhu C., Tsang J.W.H. and Guan X., Characterization of CACNA2D3 as a putative tumor suppressor gene in the development and progression of nasopharyngeal carcinoma , International Journal of Cancer. 2013, 133: 2284-2295.


Researcher : Tung E
List of Research Outputs

Lung H.L., MAN O.Y., YEUNG M.C., Ko J.M.Y., Cheung A.K.L., LAW W.L., Yu Z., SHUEN W.H., Tung E., Chan S.H.K., Bangarusamy D.K., Cheng Y., YANG X., KAN P.Q.R., PHOON Y.P., CHAN K.C., CHUA D., Kwong D.L.W., Lee A.W.M., Ji M.F. and Lung M.L., SAA1 polymorphisms are associated with variation in antiangiogenic and tumor-suppressive activities in nasopharyngeal carcinoma, Oncogene. 2014.


Researcher : WONG CL
List of Research Outputs

Yu Z., WONG C.L., Chan K.W. and Lung M.L., DNAJB6 as tumor suppressor in ESCC, 105th AACR. 2014.


Researcher : Wong HWE
List of Research Outputs

Ko J.M.Y., Dai W., Wong H.W.E., Kwong D.L.W., Ng W.T., Lee A.W.M., Ngan R.C.K., Yau C.C., Tung S. and Lung M.L., Multigene pathway-based analyses identify nasopharyngeal carcinoma risk associations for cumulative adverse effects of TERT-CLPTM1L and DNA double-strand breaks repair , International Journal of Cancer. 2014, n/a-n/a.
Lung M.L., Ko J.M.Y., Dai W., Wong H.W.E., Kwong D.L.W., Ng W.T., Lee A., Ngan R.K., Yau C.C. and Tung S., Adverse effects if TERT-CLPTM1L and double-strand breaks repair contribute to risk for NPC, 105th AACR. 2014.


Researcher : Wong SY
List of Research Outputs

Lee V.H.F., Kwong D.L.W., Lam K.O., Leung D.K.C., Ho P.P.Y., Cheung Y.T., Wong S.Y., Tsang J.W.H. and Leung T.W., Pre-treatment EBV DNA differentiates different stages of undifferentiated carcinoma of the nasopharynx, European Cancer Congress 2013. Amsterdam, European Cancer Organisation.


Researcher : Wu VWC
List of Research Outputs

Cheuk I.W., Yip S.P., Kwong D.L.W. and Wu V.W.C., Spandidos Publications 2014, 2014, 2(4): 553-8.


Researcher : YANG X
List of Research Outputs

Lung H.L., MAN O.Y., YEUNG M.C., Ko J.M.Y., Cheung A.K.L., LAW W.L., Yu Z., SHUEN W.H., Tung E., Chan S.H.K., Bangarusamy D.K., Cheng Y., YANG X., KAN P.Q.R., PHOON Y.P., CHAN K.C., CHUA D., Kwong D.L.W., Lee A.W.M., Ji M.F. and Lung M.L., SAA1 polymorphisms are associated with variation in antiangiogenic and tumor-suppressive activities in nasopharyngeal carcinoma, Oncogene. 2014.
YANG X., Dai W., Szeto C.Y.Y., Cheng Y., Kwong D.L.W. and Lung M.L., Epigenetic markers for early detection of NPC, 18th postgraduate symposium HKU. 2013.


Researcher : YEUNG MC
List of Research Outputs

Lung H.L., MAN O.Y., YEUNG M.C., Ko J.M.Y., Cheung A.K.L., LAW W.L., Yu Z., SHUEN W.H., Tung E., Chan S.H.K., Bangarusamy D.K., Cheng Y., YANG X., KAN P.Q.R., PHOON Y.P., CHAN K.C., CHUA D., Kwong D.L.W., Lee A.W.M., Ji M.F. and Lung M.L., SAA1 polymorphisms are associated with variation in antiangiogenic and tumor-suppressive activities in nasopharyngeal carcinoma, Oncogene. 2014.


Researcher : Yeung MWR
List of Research Outputs

Lee A.W.M., Ng W.T., Chan L.L., Hung W.M., Chan C.C., Sze C.K.H., Chan O.S.H., Chang A.T. and Yeung M.W.R., Evolution of treatment for nasopharyngeal cancer--success and setback in the intensity-modulated radiotherapy era, In: Jens Overgaard, Radiother Oncol.. Radiother Oncol., 2014, 110: 377-384.
Sze C.K.H., Chan L.K.L., Ng W.T., Hung W.M.A., Lee C.H.M., Chang T.Y.A., Chan O.S.H., Cheung F.Y., Yeung M.W.R. and Lee A.W.M., The prognostic significance of masticator space involvement in nasopharyngeal carcinoma. , 咀嚼肌间隙侵犯对鼻咽癌分期影响的重要意义, The 9th Pan-Pearl-River Area Congress of Radiation Oncology. 第九届泛珠会议, 2014.


Researcher : Yu Z
Project Title:AACR Annual Meeting 2014; DNAJB6a as tumor suppressor in esophageal squamous cell carcinoma
Investigator(s):Yu Z
Department:Clinical Oncology
Source(s) of Funding:URC/CRCG - Conference Support for Teaching Staff
Start Date:04/2014
Completion Date:04/2014


List of Research Outputs

Lung H.L., MAN O.Y., YEUNG M.C., Ko J.M.Y., Cheung A.K.L., LAW W.L., Yu Z., SHUEN W.H., Tung E., Chan S.H.K., Bangarusamy D.K., Cheng Y., YANG X., KAN P.Q.R., PHOON Y.P., CHAN K.C., CHUA D., Kwong D.L.W., Lee A.W.M., Ji M.F. and Lung M.L., SAA1 polymorphisms are associated with variation in antiangiogenic and tumor-suppressive activities in nasopharyngeal carcinoma, Oncogene. 2014.
Yu Z., WONG C.L., Chan K.W. and Lung M.L., DNAJB6 as tumor suppressor in ESCC, 105th AACR. 2014.


Researcher : Yung ST
List of Research Outputs

Sze C.K.H., Lau J., Chan A., Yung S.T., Luk M.Y., Leung T.W., Kwong D.L.W. and Tsang J.W.H., The use of Denosumab for breast cancer patients with bone metastases – experience from a tertiary center, 3rd International Breast Cancer Symposium. 2014.


Researcher : ZHANG L
List of Research Outputs

Zhu Y.H., Liu H., SONG Y., ZHANG L., Zeng T., Qin Y.R., Li L., Liu L., LI J., Zhang B. and Guan X., Downregulation of LGI1 promotes tumor metastasis in esophageal squamous cell carcinoma, Carcinogenesis. 2014, 35(5): 1154-1161.


Researcher : Zhu C
List of Research Outputs

Wong A.M.G., Kong K.L., Chen L., Liu M., Wong A.M.G., Zhu C., Tsang J.W.H. and Guan X., Characterization of CACNA2D3 as a putative tumor suppressor gene in the development and progression of nasopharyngeal carcinoma , International Journal of Cancer. 2013, 133: 2284-2295.


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