Dept of Pathology

DEPT OF PATHOLOGY

Researcher : Au LKS

Project Title:	EZH2 inhibition as a therapeutic strategy for hepatocellular carcinoma
Investigator(s):	Au LKS, Wong CM
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	04/2013
Completion Date:	09/2013

List of Research Outputs

Au L.K.S., Wong C.C.L., Lee M.F., Wong C.M. and Ng I.O.L., EZH2-Mediated H3K27me3 Is Involved in Epigenetic Repression of Deleted in Liver Cancer 1 in Human Cancers, PLoS One. 2013, 8: e68226.

Researcher : Beh SL

Project Title:	The attitudes of doctors toward rape victims
Investigator(s):	Beh SL
Department:	Pathology
Source(s) of Funding:	Other Funding Scheme
Start Date:	06/1993

List of Research Outputs

Beh S.L., Legal Aspects Of Traumatology And Violent Death, In: Burkhard Madea, Handbook Of Forensic Medicine. Wiley-Blackwell, 2014.

Beh S.L., Sexual Homicide, In: Burkhard Madea, Handbook Of Forensic Medicine. Wiley-Blackwell, 2014.

Beh S.L., The Teaching Of Criminology In Hong Kong, 6th Annual Conference - Asian Criminological Society - Osaka. 2014.

Beh S.L., Traumatology And Criminology, In: Burkhard Madea, Handbook Of Forensic Medicine. Wiley-Blackwell, 2014.

Researcher : CHAN KH

List of Research Outputs

Wang K., Yuen S.T., Xu J., LEE S.P., Yan H.H.N., Shi S.T., Siu H.C., Deng S., Chu K.M., Law S.Y.K., CHAN K.H., Chan A.S.Y., Tsui W.Y., Ho R.S.L., Chan K.W., Man J.L.K., Foglizzo V., Ng M.K., Chan A.S., Ching Y.P., Cheng H.W.G., Xie T., Fernandez J., Li V.S.W., Clevers H., Rejto P.A., Mao M. and Leung S.Y., Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer, Nature Genetics. 2014, 46(6): 573-582.

Researcher : Chan AOK

List of Research Outputs

Hui Y.L.E., Yeung M.C., Cheung P.T., Kwan E.Y.W., Tan K.C.B., Lam K.S.L. and Chan A.O.K., The clinical significance of aldosterone synthase deficiency: report of a novel mutation in the CYP11B2 gene., BMC Endocrine Disorder.. 2014, 14: 29.

Researcher : Chan AS

List of Research Outputs

Wang K., Yuen S.T., Xu J., LEE S.P., Yan H.H.N., Shi S.T., Siu H.C., Deng S., Chu K.M., Law S.Y.K., CHAN K.H., Chan A.S.Y., Tsui W.Y., Ho R.S.L., Chan K.W., Man J.L.K., Foglizzo V., Ng M.K., Chan A.S., Ching Y.P., Cheng H.W.G., Xie T., Fernandez J., Li V.S.W., Clevers H., Rejto P.A., Mao M. and Leung S.Y., Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer, Nature Genetics. 2014, 46(6): 573-582.

Researcher : Chan ASY

List of Research Outputs

Wang K., Yuen S.T., Xu J., LEE S.P., Yan H.H.N., Shi S.T., Siu H.C., Deng S., Chu K.M., Law S.Y.K., CHAN K.H., Chan A.S.Y., Tsui W.Y., Ho R.S.L., Chan K.W., Man J.L.K., Foglizzo V., Ng M.K., Chan A.S., Ching Y.P., Cheng H.W.G., Xie T., Fernandez J., Li V.S.W., Clevers H., Rejto P.A., Mao M. and Leung S.Y., Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer, Nature Genetics. 2014, 46(6): 573-582.

Researcher : Chan AYW

List of Research Outputs

Lee H.H.C., Poon K.H., Lai C.K., Au K.M., Siu T.S., Lai J.P., Mak C.M., Yuen Y.P., Lam C.W. and Chan A.Y.W., Hyperornithinaemia-hyperammonaemia-homocitrullinuria syndrome: a treatable genetic liver disease warranting urgent diagnosis, In: Lee HH, Poon KH, Lai CK, Au KM, Siu TS, Lai JP, Mak CM, Yuen YP, Lam CW, Chan AY, Hong Kong Med J. 2014.

Mak C.M., Lee H.H.C., Chan A.Y.W. and Lam C.W., Inborn errors of metabolism and expanded newborn screening: review and update, In: Mak CM, Lee HC, Chan AY, Lam CW, Crit Rev Clin Lab Sci. 2013.

Researcher : Chan GSW

List of Research Outputs

Tsang G.K.F., Chan G.S.W., Chan L.K. and Kwong M.M.F., Mortuary: A place more than dead body., International Conference on Grief and Bereavement (ICGB) in Contemporary Society, 11-14 June 2014, Hong Kong.. 2014.

Researcher : Chan HY

List of Research Outputs

Chiu S.Y., Chan H.Y., Shum S.K., Cheuk K.L.D., Chiang A.K.S., Ha S.Y. and Chan G.C.F., Treatment of children with drug-resistant graft-versus-host-disease by extracorporeal photopheresis, 45th Congress of the International Society of Paediatric Oncology. 2013.

Chiu S.Y., Chan H.Y., Cheuk K.L.D., Lee P.P.W., Chiang A.K.S., Ha S.Y., Chan G.C.F. and Shum S.K., Treatment of children with drug-resistant graft-versus-host-disease by extracorporeal photopheresis, The Hong Kong Paediatric Society and Hong Kong Paediatric Nurses Association Ltd Joint Annual Scientific Meeting 2013. 78.

Hung C.Y., Chiu S.Y., Shum S.K., Chan H.Y., Cheuk K.L.D., Chiang A.K.S., Ha S.Y. and Chan G.C.F., Surveillance on central venous catheter complications in paediatric haematology oncology unit, 45th Congress of the International Society of Paediatric Oncology. 2013.

Siu K.Y., Wong E.S.Y., Kong S.H., Chan H.Y., JIANG L., Wong G.W., Chan K.K.L., Ngan H.Y.S., Le X.F. and Cheung A.N.Y., Stem Cell transcription factor NANOG controls cell migration and invasion via dysregulation of E-Cadherin and Fox JI and contributes to adverse clinical outcome in ovarian cancers. 2013, 32(30): 3500-9.

Researcher : Chan KK

Project Title:	Autophagy in the chemoresistance of ovarian tumor-initiating cell
Investigator(s):	Chan KK, Cheung ANY
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2013

Project Title:	iASPP and autophagy - novel molecular targets for ovarian clear cell carcinoma
Investigator(s):	Chan KK, Cheung ANY, Wong GW, Chan KKL
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2014

List of Research Outputs

Cheung A.M., Wong G.W., Chan K.K., Wong E.S.Y. and Cheung A.N.Y., FBI-1 and choriocarcinoma cell proliferation, Hong Kong International Cancer Congress 2013.

Researcher : Chan KW

Project Title:	Identification, Characterization and Therapeutic Targeting of Tumourigenic Liver Cancer Stem Cells
Investigator(s):	Chan KW, Guan X
Department:	Pathology
Source(s) of Funding:	Michael and Betty Kadoorie Cancer Genetics Research Programme (MBKCGRP) II
Start Date:	01/2008

Project Title:	The role of interleukin-8 (IL-8) and efficacy of IL-8 targeted therapy in CD133+ cancer stem cells-driven hepatocellular carcinoma
Investigator(s):	Chan KW, Ma SKY
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2011

Project Title:	Characterization and evaluation of neuropilin-2 (NRP2) as a novel oncogene in esophageal squamous cell carcinoma (ESCC)
Investigator(s):	Chan KW
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2012
Completion Date:	05/2014

Project Title:	Functional characterization and evaluation of the metastasis promoting effect of neuropilin-2 (NRP2) in esophageal squamous cell carcinoma
Investigator(s):	Chan KW, Ma SKY, Law SYK
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2013

List of Research Outputs

Dai Y., Wilson G., Huang B., Peng M., Teng G., Zhang D., Zhang R., Ebert M.P., Chen J., Wong B.C.Y., Chan K.W., George J. and Qiao L., Silencing of Jagged1 inhibits cell growth and invasion in colorectal cancer, Cell Death Dis. 2014, 5: e1170.

Kang Y.L., Saleem M.A., Chan K.W., Yung B.Y. and Law H.K., The cytoprotective role of autophagy in puromycin aminonucleoside treated human podocytes, Biochem Biophys Res Commun. 2014, 443(2): 628-34.

Li B., Tsao G.S.W., Chan K.W., Ludwig D.L., Novosyadlyy R., Li Y.Y., He Q.Y. and Cheung A., Id1-induced IGF-II and its autocrine/endocrine promotion of esophageal cancer progression and chemoresistance-implications for IGF-II and IGF-IR-targeted therapy, Clinical Cancer Research. 2014, 2651-2662.

Li B., Tsao G.S.W., Chan K.W. and Cheung A., Id1/IGF2/IGF1R/P13K/AKT signaling cascade as functional markers and therapeutic targets in esophageal cancer, European Journal of Cancer. 2013, 49 Suppl. 4: S23 MC13-0039.

Wang K., Yuen S.T., Xu J., LEE S.P., Yan H.H.N., Shi S.T., Siu H.C., Deng S., Chu K.M., Law S.Y.K., CHAN K.H., Chan A.S.Y., Tsui W.Y., Ho R.S.L., Chan K.W., Man J.L.K., Foglizzo V., Ng M.K., Chan A.S., Ching Y.P., Cheng H.W.G., Xie T., Fernandez J., Li V.S.W., Clevers H., Rejto P.A., Mao M. and Leung S.Y., Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer, Nature Genetics. 2014, 46(6): 573-582.

XU W., Li B., Tsao G.S.W., Chan K.W. and Cheung A., Mechanistic study of the interactions between Id1-overexpressing esophageal cancer cells and fibroblasts in the tumor microenvironment, 2013 NCRI Cancer Conference, 3-6 November 2013, Liverpool, U. K.. 2013, A191.

XU W., Li B., Tsao G.S.W., Chan K.W. and Cheung A., Suppression of angiogenesis and esophageal cancer progression by selective targeting of hematopoietic and endothelial progenitor cells, 18th International Vascular Biology Meeting, April 14-17, 2014, Kyoto, Japan. 2014, P-513.

Yap Y.H.D., Chan G.S., Chan K.W., Kwan L.P., Wong W.T., Lam M.F. and Chan D.T.M., Cortical necrosis in a kidney transplant recipient due to leptospirosis, Nephrology. 2014, 19: 257-258.

Yiu W.H., WONG W.L.D., Chan Y.Y., Leung J.C.K., Chan K.W., lan H.Y., Lai K.N. and Tang S.C.W., Tissue kallikrein mediates pro-inflammatory pathways and activation of protease-activated receptor-4 in proximal tubular epithelial cells., PLoS One. 2014, 9 (2): e88894.

Yu Z., WONG C.L., Chan K.W. and Lung M.L., DNAJB6 as tumor suppressor in ESCC, 105th AACR. 2014.

Researcher : Chan KW

List of Research Outputs

Yap Y.H.D., Chan G.S., Chan K.W., Kwan L.P., Wong W.T., Lam M.F. and Chan D.T.M., Cortical necrosis in a kidney transplant recipient due to leptospirosis, Nephrology. 2014, 19: 257-258.

Yu Z., WONG C.L., Chan K.W. and Lung M.L., DNAJB6 as tumor suppressor in ESCC, 105th AACR. 2014.

Researcher : Chan LC

Project Title:	To develop a pilot humanities program in the first year undergraduate medical curriculum 2007-2008.
Investigator(s):	Chan LC
Department:	Pathology
Source(s) of Funding:	Leung Kau Kui Research and Teaching Endowment Fund - Teaching Grants
Start Date:	08/2007

List of Research Outputs

Chan L.C., CETL Seminar “Stories and the Teaching of Ethics in Healthcare – Conceptual and Experiential Approach”, Centre for the Enhancement of Teaching and Learning (CELT), The University of Hong Kong. 24 April 2014. 2014.

Chan L.C., Chen J.Y. and Tsang J.W.H., Outstanding Teaching Award (Team), The University of Hong Kong. 2013.

Chan L.C., Problem Based Learning Seminar, Faculty of Medicine & Health Sciences, Universiti Tunku Abdul Rahman, Kuala Lumpur, Malaysia. 18-19 November 2013. 2013.

Chan L.C., Reimagining Medical Education – Meaning, Curriculum and Outcome, 11th Asia Pacific Medical Education Conference (APMEC), Singapore. 15-19 January 2014. 2014.

Chan L.C., Theme “Buddhist Studies, Science and Life", 17th HKBA Joint School Teachers Development Day Seminar for all teachers of HKBA Secondary Schools, Buddhist Tai Hung College, Hong Kong. 24 May 2014. 2014.

Chan L.C., Training Doctors for Promoting Peace & Harmony at the Symposium on Peace & Health: Curriculum to Action, 45th Asia Pacific Academic Consortium for Public Health Conference, Wuhan, China. 25-27 October 2013. 2013.

Chen J.Y. and Chan L.C., Medical educators rush in where biomedical teachers fear to tread - developing a medical humanities core curriculum, Association for Medical Education in Europe (AMEE) 2013, Prague, Czech Republic. 2013.

Chen J.Y., Tsang J.W.H. and Chan L.C., Suffering, dying, grief and loss: Medical students’ photo-reflections., 10th International Conference on Grief and Bereavement in Contemporary Society, Hong Kong,. 2014.

Chen J.Y. and Chan L.C., The Person Behind the White Coat: Building a medical humanities core curriculum for medical students., 12th Canadian Conference for Medical Education/ 16th Ottawa Conference, Ottawa, Canada. 2014.

Lui W.C., Chan Y.F., Chan L.C. and Ng R.K., Cytokine combinations on the potential for ex vivo expansion of murine hematopoietic stem cells, Cytokine. Elsevier, 2014, 68: 127-132.

Ng R.K., Kong C.T., So J.C.C., Lui W.C., Chan Y.F., Leung T.K.C., So C.K.C., Tsang H.M., Chan L.C. and Sham M.H., Epigenetic dysregulation of leukaemic HOX code in MLL-rearranged leukaemia mouse model, Journal of Pathology. John Wiley & Sons, Ltd, 2014, 232: 65-74.

Ng R.K., Kong C.T., So J.C.C., Lui W.C., Chan Y.F., Leung T.K.C., So C.K.C., Tsang H.M., Chan L.C. and Sham M.H., Epigenetic dysregulation of leukemic Hox code in MLL-rearranged leukemia mouse model, Keystone Symposia Conference: Cancer Epigenetics February 4-9, 2014, New Mexico, USA. 2014.

Researcher : Chan LK

Project Title:	AACR Annual Meeting 2014; The functional role of Tensin4 in hepatocellular carcinoma
Investigator(s):	Chan LK
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2014
Completion Date:	04/2014

Researcher : Chan TL

Project Title:	Molecular characterisation of the serrated neoplasia pathway and its role in the development of colorectal cancer with mismatch repair deficiency
Investigator(s):	Chan TL, Leung SY, Yuen ST
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2005

Project Title:	Outstanding Young Researcher Award 2007-2008
Investigator(s):	Chan TL
Department:	Pathology
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	10/2008

Project Title:	The role of DNA methylation in chromosomal instability in early onset Colorectal Cancer
Investigator(s):	Chan TL
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2012

List of Research Outputs

Kuhmann C., LI C., Kloor M., Salou M., Weigel C., Schmidt C.R., Ng W.C.L., Tsui W.Y., Leung S.Y., Yuen S.T., Becker N., Weichenhan D., Plass C., Schmezer P., Chan T.L. and Popanda O., Altered regulation of DNA ligase IV activity by aberrant promoter DNA methylation and gene amplification in colorectal cancer., Hum Mol Genet. 2013, 23(8): 2043-54.

Researcher : Chan WY

Project Title:	The biological and genetic determinants of seasonal influenza A virus replication in the lower respiratory tract
Investigator(s):	Chan WY, Chan MCW, Yen H, Nicholls JM, Peiris JSM
Department:	Pathology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	02/2011
Completion Date:	09/2014

Project Title:	Neutrophil mediated host-responses during influenza A virus infection, an in vitro study
Investigator(s):	Chan WY, Chan MCW, Shum DKY, Nicholls JM, Peiris JSM
Department:	Pathology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	03/2012

Project Title:	Human primary lung microvascular endothelial responses to influenza A virus infection
Investigator(s):	Chan WY, Nicholls JM
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2012
Completion Date:	12/2013

Project Title:	The application of swine and human respiratory organ explant cultures to investigate inter-species transmission of avian influenza viruses to swine and humans
Investigator(s):	Chan WY, Chan MCW, Nicholls JM, Peiris JSM
Department:	School of Public Health
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2013

Project Title:	Influenza B virus induced host innate immune response in human primary alveolar epithelial cells
Investigator(s):	Chan WY
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2013

Project Title:	Human lung local immunity to influenza virus - role of lung antibody and resident memory T cells
Investigator(s):	Chan WY, Tu W, Nicholls JM, Peiris JSM
Department:	School of Public Health
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014

Project Title:	Influenza B viruses: Virus tropism in human and swine respiratory organ explant cultures and sero-epidemiology in swine
Investigator(s):	Chan WY, Chan MCW, Nicholls JM, Peiris JSM
Department:	School of Public Health
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2014

Project Title:	Is the loss of glycosylation in haemagglutinin protein a strategy for influenza virus to adapt in pigs?
Investigator(s):	Chan WY
Department:	School of Public Health
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2014

Researcher : Chan YF

List of Research Outputs

Lui W.C., Chan Y.F., Chan L.C. and Ng R.K., Cytokine combinations on the potential for ex vivo expansion of murine hematopoietic stem cells, Cytokine. Elsevier, 2014, 68: 127-132.

Ng R.K., Kong C.T., So J.C.C., Lui W.C., Chan Y.F., Leung T.K.C., So C.K.C., Tsang H.M., Chan L.C. and Sham M.H., Epigenetic dysregulation of leukaemic HOX code in MLL-rearranged leukaemia mouse model, Journal of Pathology. John Wiley & Sons, Ltd, 2014, 232: 65-74.

Ng R.K., Kong C.T., So J.C.C., Lui W.C., Chan Y.F., Leung T.K.C., So C.K.C., Tsang H.M., Chan L.C. and Sham M.H., Epigenetic dysregulation of leukemic Hox code in MLL-rearranged leukemia mouse model, Keystone Symposia Conference: Cancer Epigenetics February 4-9, 2014, New Mexico, USA. 2014.

Researcher : Chan YK

Project Title:	Validating and examining SNPs identified from genome-wide scanning for disease susceptibility to HBV-related liver cancer in Chinese population
Investigator(s):	Chan YK, Ng IOL, Wong CM
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2010

Researcher : Chan YTE

List of Research Outputs

Chim J.C.S., Liu H., Lie A.K.W., Chan Y.T.E., Ho S., Wong M. and Kwong Y.L., Unsustained CR of less than 24 months after autologous stem cell transplantation predicts aggressive myeloma with short survival, Hematol Oncol. 2014, Epub ahead of print.

Researcher : Chen WYW

Project Title:	Doris Zimmern HKU-Cambridge Hughes Hall Fellowships 2010-11
Investigator(s):	Chen WYW
Department:	Pathology
Source(s) of Funding:	Doris Zimmern HKU-Cambridge Hughes Hall Fellowships
Start Date:	09/2010

Project Title:	Anti-tumor effects of IL2Rα (CD25) antagonists, either as single agents or in combination with a proteasome inhibitor, Bortezomib in NK-cell malignancies
Investigator(s):	Chen WYW, Srivastava G
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	02/2011

Researcher : Cheng HWG

List of Research Outputs

Wang K., Yuen S.T., Xu J., LEE S.P., Yan H.H.N., Shi S.T., Siu H.C., Deng S., Chu K.M., Law S.Y.K., CHAN K.H., Chan A.S.Y., Tsui W.Y., Ho R.S.L., Chan K.W., Man J.L.K., Foglizzo V., Ng M.K., Chan A.S., Ching Y.P., Cheng H.W.G., Xie T., Fernandez J., Li V.S.W., Clevers H., Rejto P.A., Mao M. and Leung S.Y., Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer, Nature Genetics. 2014, 46(6): 573-582.

Researcher : Cheung ANY

Project Title:	Selecting most suitable students for production of best medical doctors-which criteria should we use?
Investigator(s):	Cheung ANY, Patil NG, Ip MSM, Chan LC
Department:	Pathology
Source(s) of Funding:	Leung Kau Kui Research and Teaching Endowment Fund - Teaching Grants
Start Date:	02/2005

Project Title:	Akt and p21-activated kinase signaling pathways in gestational trophoblastic disease
Investigator(s):	Cheung ANY, Ngan HYS, Siu KY
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2007

Project Title:	Folate and folate receptor alpha in ovarian cancers
Investigator(s):	Cheung ANY, Siu KY
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2007

Project Title:	Cervical cancer screening by enhanced cervical cytology-application of novel markers
Investigator(s):	Cheung ANY, Ngan HYS, Guan X
Department:	Pathology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	03/2007

Project Title:	Centre for Research into Circulating Fetal Nucleic Acids
Investigator(s):	Cheung ANY
Department:	Pathology
Source(s) of Funding:	Areas of Excellence Scheme
Start Date:	01/2008

Project Title:	FBI-1 in ovarian carcinogenesis and progression
Investigator(s):	Cheung ANY, Siu KY, Ngan HYS
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2009

Project Title:	HPV detection as an adjunct for triage of atypical cervical cytology in screening for cervical cancer
Investigator(s):	Cheung ANY
Department:	Pathology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	11/2009

Project Title:	FBI-1 (Pokemon) in Gestational Trophoblastic Disease
Investigator(s):	Cheung ANY, Ngan HYS, Siu KY, Wong GW
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2012

Project Title:	p21-activated kinase 4 in chemosensitivity of ovarian cancer
Investigator(s):	Cheung ANY, Ngan HYS, Wong GW
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2012
Completion Date:	12/2013

Project Title:	Tumour Microenvironment - New concepts and molecular mechanisms
Investigator(s):	Cheung ANY, Ng IOL, Khoo US, Lung ML, Ngan HYS
Department:	Pathology
Source(s) of Funding:	Croucher Advanced Study Institute
Start Date:	01/2012

Project Title:	HPV detection as an adjunct for triage of atypical cervical cytology in screening for cervical cancer
Investigator(s):	Cheung ANY, Ngan HYS
Department:	Pathology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	02/2012

Project Title:	Outstanding Research Student Supervisor Award 2011-12
Investigator(s):	Cheung ANY
Department:	Pathology
Source(s) of Funding:	Outstanding Research Student Supervisor Award
Start Date:	01/2013

Project Title:	Apoptosis stimulating proteins of p53 and gestational trophoblastic disease
Investigator(s):	Cheung ANY, Ngan HYS, Wong GW
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2013

Project Title:	3rd Biennial Meeting of Asian Society of Gynecologic Oncology; Pathology of endometrial cancer and its precursor
Investigator(s):	Cheung ANY
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	12/2013

Project Title:	p53 related proteins and gestational trophoblastic disease
Investigator(s):	Cheung ANY, Wong GW, Ngan HYS
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2014

Project Title:	Placental biology of Down Syndrome in relation to increased gene dosage
Investigator(s):	Cheung ANY, Wong GW, Ngan HYS
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2014

Project Title:	AMPK and metabolism in choriocarcinoma
Investigator(s):	Cheung ANY, Chan KK
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2014

List of Research Outputs

Chan R.W.S., Mak A.S., Yeung W.S.B., Lee C.K.F., Cheung A.N.Y., Ngan H.Y.S. and Wong A.S., Human female reproductive tract epithelial cell culture., Methods Mol Biol.. 2013, 945: 347-363.

Cheung A.M., Wong G.W., Chan K.K., Wong E.S.Y. and Cheung A.N.Y., FBI-1 and choriocarcinoma cell proliferation, Hong Kong International Cancer Congress 2013.

Cheung A.N.Y., Chapter 1 Tumors of the Ovary: Secondary Tumors Chapter 2 Tumours of the peritoneum Chapter 6 Gestational trophoblastic disease, In: Cheung AN, 4th edition of WHO Classification of Tumours of Female Reproductive Organs . 2014.

Cheung A.N.Y., Croucher Senior Medical Research Fellowship, The Croucher Foundation. 2014.

Cheung A.N.Y., Section Editor, In: Cheung AN, Management of Gestational Trophoblastic Diseases section of Volume 3, Issue 1 (March 2014), Current Obstetrics and Gynaecology Reports. Springer, 2014.

LEUNG O.N., Deng W., Ye T., Ngan H.Y.S., Tsao G.S.W., Cheung A.N.Y., Pang R.T.K. and Yeung W.S.B., miR-135a leads to cervical cancer cell transformation through regulation of β-catenin via a SIAH1-dependent ubiquitin proteosomal pathway, Carcinogenesis. 2014.

Lam S.N., Mak A.S.C., Yam J.W.P., Cheung A.N.Y., Ngan H.Y.S. and Wong A.S.T., Targeting estrogen-related receptor alpha inhibits epithelial-to-mesenchymal transition and stem cell properties of ovarian cancer cells, In: Lam SS, Mak AS, Yam JW, Cheung AN, Ngan HY, Wong AS, Mol Ther. 2014.

Leung C.O., Deng W., Ye T.M., Ngan H.Y.S., Tsao S.W., Cheung A.N.Y., Pang R.T.K. and Yeung W.S.B., miR-135a leads to cervical cancer cell transformation through regulation of β-catenin via a SIAH1-dependent ubiquitin proteosomal pathway, Carcinogenesis. 2014.

Leung T.H.Y., WONG C.S., Chan K.K.L., Chan D.W., Cheung A.N.Y. and Ngan H.Y.S., The interaction between C35 and ΔNp73 promotes chemo-resistance in ovarian cancer cells, British Journal of Cancer. 2013, 109: 965-975.

O W.S., Li R.H.W., Liao S., Cheung A.N.Y., Ng E.H.Y., Yeung W.S.B., Ho J.C.M. and Tang F., Decreases in adrenomedullin expression and ciliary beat frequency in the nasal epithelium in tubal pregnancy, Fertility and Sterility. 2013, 100: 459-463.e1.

Pang R.T.K., LEUNG O.N., YE T., Ngan H.Y.S., Cheung A.N.Y. and Yeung W.S.B., CERVICAL CANCER CD133 POSITIVE CELLS POSSESS TUMOR INITIATING CELLS PROPERTIES, 18th International Meeting of the European Society of Gynaecological Oncology (ESGO). International Journal of Gynecological Cancer, 2013.

Seto T.Y.M., Ip P.P.C., Ngu S.F., Cheung A.N.Y. and Pun T.C., Diagnostic Accuracy of Endometrial Polyps in Pipelle Endometrial Samples: A Clinicopathologic Study of 195 Cases, United States & Canadian Academy of Pathology’s 103rd Annual Meeting. 2014.

Siu K.Y., Wong E.S.Y., Kong S.H., Chan H.Y., JIANG L., Wong G.W., Chan K.K.L., Ngan H.Y.S., Le X.F. and Cheung A.N.Y., Stem Cell transcription factor NANOG controls cell migration and invasion via dysregulation of E-Cadherin and Fox JI and contributes to adverse clinical outcome in ovarian cancers. 2013, 32(30): 3500-9.

Tang K.S., Kwong A., Tam K.F., Cheung A.N.Y., Ngan H.Y.S., Xia W. and Wong A.S.T., BRCA1 deficiency induces protective autophagy to mitigate stress and provides a mechanism for BRCA1 haploinsufficiency in tumorigenesis, In: Tang MK, Kwong A, Tam KF, Cheung AN, Ngan HY, Xia W, Wong AS, Cancer Lett. 2014.

Zhao F., Siu K.Y., Wong G.W., Wong E.S.Y., Jiang L.L., Tam K.F., Ngan H.Y.S., Le X.F., Lam E.W.F. and Cheung A.N.Y., Role of FOXM1 in ovarian carcinogenesis, In: Zhao F, Siu MK, Wong OG, Wong ES, Jiang LL, Tam KF, Ngan HY, Le XF, Lam EWF, Cheung AN, AACR conference Advances in Ovarian Cancer Research: From Concept to Clinic. September 18-21, 2013. Miami, USA. Proceedings of the American Association for Cancer Research. 2013.

Researcher : Cheung KK

List of Research Outputs

Lam C.W., Law C.Y., To K.K.W., Cheung K.K., Lee K.C., Sze K.H. and Yuen K.Y., Springer Poster Prize For Outstanding Poster Presentation Of Research In The Field Of Metabolomics In The Metabolomics Society 2013 Conference , Metabolomics Society 2013 Conference . 2013.

Law C.Y., Cheung K.K. and Lam C.W., Performance Of High-resolution 1h Nuclear Magnetic Resonance Spectroscopy Analysis Versus Jaffe Reaction For Urinary Creatinine Quantification, International Symposium on Translating Omics Science to Clinical Applications 2013 (TOSCA'13). 2013.

To K.K.W., Lam C.W., Wong S.S.Y., Law C.Y., Lee K.C., Yung K.Y., Cheung K.K. and Chan S.F., Urine Metabolomics Profile Of Patients With Or Without Bacteremia, International Symposium on Translating Omics Science to Clinical Applications 2013 (TOSCA'13). 2013.

Researcher : Cheung MFF

List of Research Outputs

Chow J.P., Man W.Y., Mao M., Chen H., Cheung M.F.F., Nicholls J.M., Tsao G.S.W., Lung M.L. and Poon R.Y., Poly(ADP-ribose) polymerase 1 is overexpressed in nasopharyngeal carcinoma and its inhibition enhances radiotherapy, Molecular Cancer Therapeutics. 2013, 12(11): 2517-28.

Researcher : Cheung YN

Project Title:	AACR 101st Annual Meeting eIF4E in human breast cancer and its role in regulating translation of splice variants of breast cancer genes
Investigator(s):	Cheung YN
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2010

Researcher : Ching YP

Project Title:	Roles of p21-activated protein kinase (Pak) 1 in the pathogenesis of liver cancer
Investigator(s):	Ching YP, Ng IOL, Jin D, Yau TO
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2006

Project Title:	Hepatitis B virus promotes hepatocarcinogenesis by activation of Pak1
Investigator(s):	Ching YP, Jin D
Department:	Anatomy
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2010
Completion Date:	08/2014

Project Title:	Regulation of p53 by PAK4 in hepatocellular carcinoma
Investigator(s):	Ching YP
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2012
Completion Date:	04/2014

Project Title:	HBx oncoprotein induces chromosome instability in hepatocarcinogenesis via dysregulation of centrosome duplication regulatory protein, TAX1BP2
Investigator(s):	Ching YP, Jin D
Department:	Anatomy
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	03/2013

Project Title:	The role of centrosomal kinase Nek2 in the pathogenesis of liver cancer
Investigator(s):	Ching YP
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2013

Project Title:	Functional characterization of the roles of NIMA-related kinase, Nek2 in liver cancer development and metastasis
Investigator(s):	Ching YP
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2014

Researcher : Chiu PM

List of Research Outputs

Cheng Y., Cheung A.K.L., Ko J.M.Y., PHOON Y.P., Chiu P.M., Lo P.H., Waterman M.L. and Lung M.L., Physiological beta-catenin signaling controls self-renewal networks and generation of stem-like cells from nasopharyngeal carcinoma, BMC Cell Biol. BMC, 2013, 14(1): 44.

LI C., Liu V.W.S., Chiu P.M., Yao K.M., Ngan H.Y.S. and Chan D.W., Reduced expression of AMPK-beta1 during tumor progression enhances the oncogenic capacity of advanced ovarian cancer, In: Christophe Nicot, Molecular Cancer. United Kingdom, BioMed Central, 2014, 13: 49.

Researcher : Chiu YT

Project Title:	Dissecting the gender disparity of hepatocellular carcinoma - Roles of androgen receptor signaling in hepatocarcinogenesis
Investigator(s):	Chiu YT, Ng IOL
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	05/2012
Completion Date:	10/2013

Project Title:	Analysis of hepatitis B virus genomic integration and characterization of its role in hepatocarcinogenesis
Investigator(s):	Chiu YT, Ng IOL, Ho DWH
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	10/2013

Project Title:	The significance of X-linked MID1 interacting protein 1 (MID1IP1) in hepatocarcinogenesis
Investigator(s):	Chiu YT, Ng IOL
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2014

List of Research Outputs

Kwan P.S., Lau C.C., Chiu Y.T., Wong Y.C. and Ling M.T., Daxx regulates mitotic progression and prostate cancer predisposition, Carcinogenesis. 2013, 34: 750-759.

Researcher : Cho SY

List of Research Outputs

Cho S.Y., Siu T.S., Ma O., Tam S. and Lam C.W., Novel mutations in myopathic form of carnitine palmitoyltransferase II deficiency in a Chinese patient, In: Cho SY, Siu TS, Ma O, Tam S, Lam CW, Clin Chim Acta . 2013.

Researcher : Choi WL

Project Title:	Correlation of the AML1-ETO isoform transcript levels with the prognosis of patients with acute myeloid leukemia (AML) with t(8;21)
Investigator(s):	Choi WL, Chan LC, So JCC, Ha SY, Leung AYH
Department:	Pathology
Source(s) of Funding:	Queen Mary Hospital Charitable Trust - Training and Research Assistance Scheme
Start Date:	04/2011

Project Title:	Identification of FOXP1 target genes in diffuse large B-cell lymphoma
Investigator(s):	Choi WL
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	02/2012
Completion Date:	01/2014

List of Research Outputs

HE B., SHI X., Man C.H., Ma C.H., Ekker S.C., Chow C.H., So C.W., Choi W.L., Zhang W., Zhang Y. and Leung A.Y.H., Functions of flt3 in zebrafish hematopoiesis and its relevance to human acute myeloid leukemia., Blood. USA, American Society of Hematology, 2014, 123: 2518-2529.

Researcher : Chu KY

List of Research Outputs

Sze M.F., Chu K.Y., Mak H.Y., Lee M.F. and Ng I.O.L., Proline-rich acidic protein 1 (PRAP1) is a novel interacting partner of MAD1 and has a suppressive role in mitotic checkpoint signalling in hepatocellular carcinoma., In: Peter A Hall, Journal of Pathology. Great Britain and Ireland, John Wiley & Sons, Ltd, 2014, 233(1): 51-60.

Researcher : Chung LP

List of Research Outputs

Lee V.H.F., Tin P.C., Choy T.S., Lam K.O., Choi C.W., Chung L.P., Tsang J.W.H., Ho P.P., Leung D.K., Ma E.S., Liu J., Shek T.W.H., Kwong D.L.W., Leung T.W. and Wong M.P., Association of Exon 19 and 21 EGFR Mutation Patterns with Treatment Outcome after First-Line Tyrosine Kinase Inhibitor in Metastatic Non-Small-Cell Lung Cancer, In: Lee VH, Tin VP, Choy TS, Lam KO, Choi CW, Chung LP, Tsang JW, Ho PP, Leung DK, Ma ES, Liu J, Shek TW, Kwong DL, Leung TW, Wong MP, J Thorac Oncol. 2013, 8(9):1148-55.

So J.C.C., Chan A. and Chung L.P., A Comparison of high resolution melting, allele-specific priming and Sanger sequencing for the detection of BRAFV600E mutation in hairy cell leukaemia from different haematological specimens, XXVII Symposium on Technological Innovations in Laboratory Hematology, The Netherlands. 2014.

de Figueiredo-Pontes L.L., Wong D.W.S., Tin P.C., Chung L.P., Yasuda H., Yamaguchi N., Nakayama S., Jänne P.A., Wong M.P., Kobayashi S.S. and Costa D.B., Identification and Characterization of ALK Kinase Splicing Isoforms in Non-Small-Cell Lung Cancer, In: de Figueiredo-Pontes LL, Wong DW, Tin VP, Chung LP, Yasuda H, Yamaguchi N, Nakayama S, Jänne PA, Wong MP, Kobayashi SS, Costa DB, Journal of Thoracic Oncology. 2014, 9(2): 248–253.

Researcher : Ha SY

List of Research Outputs

Chen M.P., Li S.N., Lam W.W.M., Ho Y.C., Ha S.Y., Chan G.C.F. and Cheung Y.F., Left ventricular torsional mechanics and myocardial iron load in beta-thalassaemia major: a potential role of titin degradation , BMC Cardiovascular Disorders . 2014, 14: 49 (doi:10.1186/1471-2261-14-49.

Researcher : Ho DWH

Project Title:	Integrative investigation of somatic copy number and gene expression alterations in human hepatocellular carcinoma
Investigator(s):	Ho DWH, Ng IOL
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2014

List of Research Outputs

Ho D.W.H. and Yip S.P., Whole genome amplification: Technologies and applications., Genomics III – Methods, Techniques and Applications. iConcept Press Ltd., 2014.

Kwok T., Ho D.W.H., Chan G., Ip I., Wong B. and Ho F., Evaluation of day care services for demented clients in Hong Kong , Asian Journal of Gerontology and Geriatrics. 2014, 9: 5-9.

Kwok T., Leung P.C., Wing Y.K., Ip I., Wong B., Ho D.W.H., Wong W.M. and Ho F., The effectiveness of acupuncture on the sleep quality of elderly with dementia: A within-subjects trial, Clinical Interventions in Aging. 2013, 8: 923-9.

Researcher : Ho RSL

List of Research Outputs

Wang K., Yuen S.T., Xu J., LEE S.P., Yan H.H.N., Shi S.T., Siu H.C., Deng S., Chu K.M., Law S.Y.K., CHAN K.H., Chan A.S.Y., Tsui W.Y., Ho R.S.L., Chan K.W., Man J.L.K., Foglizzo V., Ng M.K., Chan A.S., Ching Y.P., Cheng H.W.G., Xie T., Fernandez J., Li V.S.W., Clevers H., Rejto P.A., Mao M. and Leung S.Y., Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer, Nature Genetics. 2014, 46(6): 573-582.

Researcher : Huang F

List of Research Outputs

Sattler S., Ling G.S., Xu D., Hussaarts L., Romaine A., Zhao H.Z., Fossati-Jimack L., Malik T., Cook H.T., Botto M., Lau Y.L., Smits H.H., Liew F.Y. and Huang F., IL-10-producing regulatory B cells induced by IL-33 (BregIL-33) effectively attenuate mucosal inflammatory responses in the gut, In: M.E. Gershwin, Journal of Autoimmunity. Elsevier, 2014, 50: 107-122.

Wang T., Sun X., Zhao J., Zhang J., Zhu H., Li C., Gao N., Jia Y., Xu D. and Huang F., Regulatory T cells in rheumatoid arthritis showed increased plasticity toward Th17 but retained suppressive function in peripheral blood, Annals of the Rheumatic Diseases. 2014.

Researcher : Ip HW

List of Research Outputs

Ip H.W. and So J.C.C., Diagnosis and prevention of thalassemia, Crit Rev Clin Lab Sci. 2013, 50(6): 125-41.

Researcher : Ip PPC

List of Research Outputs

Seto T.Y.M., Ip P.P.C., Ngu S.F., Cheung A.N.Y. and Pun T.C., Diagnostic Accuracy of Endometrial Polyps in Pipelle Endometrial Samples: A Clinicopathologic Study of 195 Cases, United States & Canadian Academy of Pathology’s 103rd Annual Meeting. 2014.

Wong D.K.H., Lai C.L., Ip P.P.C., Kopaniszen M., Seto W.K.W., Fung J.Y.Y., Huang F.Y., Wu C.H., Cheng C.T.K., Ngai W.S. and Yuen R.M.F., The effect of long-term nucleoside/tide analogue treatment on intrahepatic HBVDNA and covalently closed circular DNA in chronic hepatitis B patients, Poster presentation at the International Liver Congress™ 2014 – 49^th Annual meeting of the European Association for the Study of the Liver. Journal of hepatology : the journal of the European Association for the Study of the Liver. 2014, 60(1): S435.

Researcher : JIANG L

List of Research Outputs

Siu K.Y., Wong E.S.Y., Kong S.H., Chan H.Y., JIANG L., Wong G.W., Chan K.K.L., Ngan H.Y.S., Le X.F. and Cheung A.N.Y., Stem Cell transcription factor NANOG controls cell migration and invasion via dysregulation of E-Cadherin and Fox JI and contributes to adverse clinical outcome in ovarian cancers. 2013, 32(30): 3500-9.

Researcher : Kai AKL

Project Title:	The roles of chemokine C-C motif ligand 28 (CCL28) in hepatocarcinogenesis
Investigator(s):	Kai AKL, Ng IOL
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	03/2014

Project Title:	American association of cancer research annual meeting 2014; Hypoxia-inducible HIF1α-miR-210 signaling axis enhances chemoresistance in human hepatocellular carcinoma
Investigator(s):	Kai AKL
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2014

List of Research Outputs

Wong C.C.L., Kai A.K.L. and Ng I.O.L., The Impact Of Hypoxia In Hepatocellular Carcinoma Metastasis, Frontiers Of Medicine. 2014.

Researcher : Khoo US

Project Title:	Association of the pro-inflammatory and anti-inflammatory cytokine gene polymorphism to breast cancer susceptibility
Investigator(s):	Khoo US, Cheung ANY, Chan YK
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Project Title:	Infectious Diseases and Global Health: Genetic approach to the identification of host susceptibility factors and pathogen virulence determinants. Genetics of coronaviruses-associated acute respiratory disease
Investigator(s):	Khoo US
Department:	Pathology
Source(s) of Funding:	CGDN NCE Large Scale Collaborative Research Grant
Start Date:	02/2005

Project Title:	HER2 FISH test to assess eligibility for transtuzumab (herceptin) in breast cancer patients applying for assistance from Samaritan Fund for treatment
Investigator(s):	Khoo US, Au GKH, Leung TW, Luk MY, Yau TK
Department:	Pathology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	07/2010

Project Title:	Characterization of candidate microRNAs associated with Tamoxifen resistance in breast cancer
Investigator(s):	Khoo US, Cheung YN
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	03/2011
Completion Date:	02/2014

Project Title:	The role of eIF4E in regulating translation of splice variants of breast cancer related genes
Investigator(s):	Khoo US
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	05/2012
Completion Date:	05/2014

Project Title:	Role of eIF4E in tamoxifen resistance in breast cancer
Investigator(s):	Khoo US
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	05/2013

Project Title:	Antibody specific splice variant as biomarker for tamoxifen responsiveness in breast cancer
Investigator(s):	Khoo US, Man PS
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	06/2013
Completion Date:	05/2014

Project Title:	8th Asia Pacific IAP Congress; Genetic Predisposition to Breast Cancer: the Significance of the BRCA genes
Investigator(s):	Khoo US
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2013
Completion Date:	09/2013

Project Title:	HER2 Dual ISH test to assess eligibility for Trastuzumab (Herceptin) in breast cancer patients receiving treatment from public hospitals
Investigator(s):	Khoo US, Leung TW, Luk MY, Yeung MWR
Department:	Pathology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	11/2013

Project Title:	Development of Antibody Specific to Splice Variant of NCOR2 for the Management of Breast Cancer
Investigator(s):	Khoo US, Lee KW, Tsang JWH, Man PS
Department:	Pathology
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	12/2013

Project Title:	Development of Antibody Specific to Splice Variant of NCOR2 for the Management of Breast Cancer
Investigator(s):	Khoo US, Lee KW, Tsang JWH, Man PS
Department:	Pathology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	01/2014

Project Title:	Development of Antibody Specific to Splice Variant of NCOR2 for the Management of Breast Cancer
Investigator(s):	Khoo US, Lee KW, Tsang JWH, Man PS
Department:	Pathology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	01/2014

Project Title:	Development of a method for ex vivo expansion of in vivo captured circulating tumor cells from breast cancer patients for molecular profiling.
Investigator(s):	Khoo US, Tsang JWH, Tang MKP
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	06/2014

List of Research Outputs

Khongkow M., Olmos Y., Gong C., Gomes A.R., Monteiro L.J., Yague E., Cavaco T.B., Khongkow P., Man E.P., Laohasinnarong S., Koo C.Y., Harada-Shoji N., Tsang J.W.H., Coombes R.C., Schwer B., Khoo U.S. and Lam E.W., SIRT6 modulates paclitaxel and epirubicin resistance and survival in breast cancer, Carcinogenesis. 2013, 34(7): 1476-86.

Khoo U.S., Genetic Predisposition to Breast Cancer: the Significance of the BRCA genes, 8th Asia Pacific IAP Congress, Korea. 2013.

Khoo U.S., Genetic Predisposition to Breast Cancer: the Significance of the BRCA genes, 8th Asia Pacific IAP Congress, Korea, 2013. 2013.

Khoo U.S., Virtual Microscopy and On-line Case Vignette Study for Pathology Teaching, Frontiers in Medical and Health Science Education, Hong Kong. 2013.

Researcher : Ko FCF

Project Title:	Unravel the RhoGAP independent pathway of Deleted in Liver Cancer 1 tumor suppressor
Investigator(s):	Ko FCF, Yam JWP
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	05/2012

Project Title:	AACR Annual Meeting 2014; Novel RhoGAP independent pathway of tumor suppressor DLC1 regulates cancer invasion and metastasis
Investigator(s):	Ko FCF
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2014
Completion Date:	04/2014

Project Title:	The study of DLC1 regulates oxidative stress for tumor suppression
Investigator(s):	Ko FCF, Yam JWP
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2014

List of Research Outputs

Ko F.C.F., Yeung Y.S., Mao X. and Yam J.W.P., Novel RhoGAP independent pathway of tumor suppressor DLC1 regulates cancer invasion and metastasis, 2014 American Association for Cancer Research Annual Meeting. 2014.

Ko F.C.F. and Yam J.W.P., Regulation of Deleted in Liver Cancer 1 tumor suppressor by protein-protein interactions and phosphorylation, International Journal of Cancer. 2013, 135: 264-269.

Researcher : Kong SH

List of Research Outputs

Siu K.Y., Wong E.S.Y., Kong S.H., Chan H.Y., JIANG L., Wong G.W., Chan K.K.L., Ngan H.Y.S., Le X.F. and Cheung A.N.Y., Stem Cell transcription factor NANOG controls cell migration and invasion via dysregulation of E-Cadherin and Fox JI and contributes to adverse clinical outcome in ovarian cancers. 2013, 32(30): 3500-9.

Researcher : LEE SP

List of Research Outputs

Wang K., Yuen S.T., Xu J., LEE S.P., Yan H.H.N., Shi S.T., Siu H.C., Deng S., Chu K.M., Law S.Y.K., CHAN K.H., Chan A.S.Y., Tsui W.Y., Ho R.S.L., Chan K.W., Man J.L.K., Foglizzo V., Ng M.K., Chan A.S., Ching Y.P., Cheng H.W.G., Xie T., Fernandez J., Li V.S.W., Clevers H., Rejto P.A., Mao M. and Leung S.Y., Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer, Nature Genetics. 2014, 46(6): 573-582.

Researcher : LI C

List of Research Outputs

Kuhmann C., LI C., Kloor M., Salou M., Weigel C., Schmidt C.R., Ng W.C.L., Tsui W.Y., Leung S.Y., Yuen S.T., Becker N., Weichenhan D., Plass C., Schmezer P., Chan T.L. and Popanda O., Altered regulation of DNA ligase IV activity by aberrant promoter DNA methylation and gene amplification in colorectal cancer., Hum Mol Genet. 2013, 23(8): 2043-54.

Researcher : LO J

List of Research Outputs

LO J., Ng I.O.L. and Lee K.W., CD47,a potential therapeutic target for hepatocellular carcinoma, Journal of Liver: Disease &Transplantation. 2013, 2: 2.

Researcher : Lai JCC

Project Title:	Comparison of native influenza virus and virus-like-particles in their receptor-binding properties
Investigator(s):	Lai JCC, Nicholls JM
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	05/2014

List of Research Outputs

Garcia J.C., Lai J.C.C., Haselhorst T., Choy K.T., Yen H., Peiris J.S.M., Itzstein M.V. and Nicholls J.M., Investigation of the binding and cleavage characteristics of N1 neuraminidases from avian, seasonal, and pandemic influenza viruses using saturation transfer difference nuclear magnetic resonance, Influenza and Other Respiratory Viruses. 2014, 8(2): 235-42.

Lee M.Y., Kok K.H., Jaume M.D.A., Cheung K.W., Yip T.F., Lai J.C.C., Guan Y., Webster R.G., Jin D. and Peiris J.S.M., Toll-like receptor 10 is involved in induction of innate immune responses to influenza virus infection, Proceedings of the National Academy of Sciences of the United States of America. 2014, 111(10): 3793-8.

Researcher : Lam CCK

List of Research Outputs

So J.C.C., Chan A.Y. and Lam C.C.K., Novel point mutation of the α2-globin gene (HBA2) and a rare 2.4 kb deletion of the α1-globin gene (HBA1), identified in two chinese patients with Hb H disease, Hemoglobin. 2014, 38(3): 213-5.

Researcher : Lam CW

Project Title:	Whole genome scan of genetic susceptibility for hepatitis B carries
Investigator(s):	Lam CW
Department:	Pathology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	04/2006
Completion Date:	08/2014

Project Title:	The first prospective second generation newborn screening in Hong Kong
Investigator(s):	Lam CW, Chan AYW, Mak CM
Department:	Pathology
Source(s) of Funding:	S.K. Yee Medical Foundation - General Award
Start Date:	10/2012

Project Title:	Identifying the disease gene for a new locus of congenital myasthenic syndrome
Investigator(s):	Lam CW
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2012
Completion Date:	11/2013

Project Title:	Food
Investigator(s):	Lam CW, Wang M
Department:	Pathology
Source(s) of Funding:	Seed Funding for Strategic Research Theme
Start Date:	09/2013

Project Title:	Pathology Update 2014 ; Neogenin mutations in autism spectrum disorders
Investigator(s):	Lam CW
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	02/2014
Completion Date:	02/2014

List of Research Outputs

Cheung K.M., Lam C.W., Chan Y.K., Siu C.W.K. and Yong L., Atypical focal cortical dysplasia in a patient with Cowden syndrome, In: Cheung KM, Lam CW, Chan YK, Siu WK, Yong L, Hong Kong Med J. 2014.

Cho S.Y., Siu T.S., Ma O., Tam S. and Lam C.W., Novel mutations in myopathic form of carnitine palmitoyltransferase II deficiency in a Chinese patient, In: Cho SY, Siu TS, Ma O, Tam S, Lam CW, Clin Chim Acta . 2013.

Ho C.C.A., Fung C.W., Siu T.S., Ma O.C.K., Lam C.W., Tam S. and Wong V.C.N., Lathosterolosis: A Disorder Of Cholesterol Biosynthesis Resembling Smith-lemli-opitz Syndrome, Journal Of Inherited Metabolic Disease . 2014, 12: 129-134.

Lam C.W., Genodermatoses, 9th Asian Dermatological Congress 2013 (10-13 July 2013) Hong Kong, Asian Dermatological Association, Hong Kong College of Dermatologists and The Hong Kong Society of Dermatology and Venereology. 2013.

Lam C.W., Law C.Y., To K.K., Cheung S.K., Lee K.C., Sze K.H., Leung K.F. and Yuen K.Y., NMR-based metabolomic urinalysis: A rapid screening test for urinary tract infection, In: Lam CW, Law CY, To KK, Cheung SK, Lee KC, Sze KH, Leung KF, Yuen KY, Clin Chim Acta. 2014, 436: 217–223.

Lam C.W., PrimeIndel: Four-prime-number genetic code for indel decryption and sequence read alignment, In: Lam CW, Clin Chim Acta. 2014.

Lam C.W., Law C.Y., To K.K.W., Cheung K.K., Lee K.C., Sze K.H. and Yuen K.Y., Springer Poster Prize For Outstanding Poster Presentation Of Research In The Field Of Metabolomics In The Metabolomics Society 2013 Conference , Metabolomics Society 2013 Conference . 2013.

Law C.Y., Cheung K.K. and Lam C.W., Performance Of High-resolution 1h Nuclear Magnetic Resonance Spectroscopy Analysis Versus Jaffe Reaction For Urinary Creatinine Quantification, International Symposium on Translating Omics Science to Clinical Applications 2013 (TOSCA'13). 2013.

Lee H.H.C., Mak C.M., Poon W.K.G., Wong K.Y. and Lam C.W., Cost-benefit analysis of Hyperphenylalaninemia Due to 6-Pyruvoyl-Tetrahydropterin Synthase (PTPS) Deficiency: For Consideration of Expanded Newborn Screening in Hong Kong, In: Lee HH, Mak CM, Poon GW, Wong KY, Lam CW, J Med Screen. 2014.

Lee H.H.C., Poon K.H., Lai C.K., Au K.M., Siu T.S., Lai J.P., Mak C.M., Yuen Y.P., Lam C.W. and Chan A.Y.W., Hyperornithinaemia-hyperammonaemia-homocitrullinuria syndrome: a treatable genetic liver disease warranting urgent diagnosis, In: Lee HH, Poon KH, Lai CK, Au KM, Siu TS, Lai JP, Mak CM, Yuen YP, Lam CW, Chan AY, Hong Kong Med J. 2014.

Lee H.H.C., Poon K.H., Lai C.K., Au K.M., Siu T.S., Lai J.P.S., Mak C.M., Yuen L.Y.P., Lam C.W. and Chan A.Y.W., Hyperornithinaemia-hyperammonaemia-homocitrullinuria syndrome: a treatable genetic liver disease warranting urgent diagnosis, In: Lee HH, Poon KH, Lai CK, Au KM, Siu TS, Lai JP, Mak CM, Yuen YP, Lam CW, Chan AY, Hong Kong Medical Journal. 2014, 20: 63-66.

Mak C.M., Lee H.H.C., Chan A.Y.W. and Lam C.W., Inborn errors of metabolism and expanded newborn screening: review and update, In: Mak CM, Lee HC, Chan AY, Lam CW, Crit Rev Clin Lab Sci. 2013.

Mak C.M., Lee H.H.C., Chan A.Y.W. and Lam C.W., Inborn errors of metabolism and expanded newborn screening: review and update, In: Mak CM, Lee HC, Chan AY, Lam CW, Critical Reviews in Clinical Laboratory Sciences. 2013, 50: 142-162.

Tam W.T., Chen J.H.K., Lau E.C.L., Ngan A.H.Y., Fung K.S.C., Lee K.C., Lam C.W., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Misidentification of Aspergillus nomius and Aspergillus tamarii as Aspergillus flavus: Characterization by Internal Transcribed Spacer, -Tubulin, and Calmodulin Gene Sequencing, Metabolic Fingerprinting, and Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry, In: Tam EW, Chen JH, Lau EC, Ngan AH, Fung KS, Lee KC, Lam CW, Yuen KY, Lau SK, Woo PC, Journal of Clinical Microbiology. 2014, 52: 1153-1160.

Tam W.T., Chen J.H.K., Lau E.C., Ngan A.H., Fung K.S., Lee K.C., Lam C.W., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Misidentification of Aspergillus nomius and Aspergillus tamarii as Aspergillus flavus: characterization by internal transcribed spacer, β-Tubulin, and calmodulin gene sequencing, metabolic fingerprinting, and matrix-assisted laser desorption ionization-time of flight mass spectrometry, In: Tam EW, Chen JH, Lau EC, Ngan AH, Fung KS, Lee KC, Lam CW, Yuen KY, Lau SK, Woo PC, J Clin Microbiol. 2014.

To K.K.W., Lam C.W., Lee K.C., Yung K.Y., Law C.Y., Leung K.F., Lau K.C. and Chan S.F., Difference In The Metabolome Between Escherichia Coli Isolated From Patients With Pyelonephritis And Cholangitis, Metabolomics Society 2013 Conference . 2013.

To K.K.W., Lam C.W., Wong S.S.Y., Law C.Y., Lee K.C., Yung K.Y., Cheung K.K. and Chan S.F., Urine Metabolomics Profile Of Patients With Or Without Bacteremia, International Symposium on Translating Omics Science to Clinical Applications 2013 (TOSCA'13). 2013.

Researcher : Law CY

Project Title:	Metabolomics Society 2013 Conference 9th International Conference of the Metabolomics Society; Quantitative high resolution 1H NMR urinalysis for algorithmic diagnosis of urinary tract infection using an automatic analyzer/Urine metabolomics profile of patients with or without bacteremia
Investigator(s):	Law CY
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2013
Completion Date:	07/2013

List of Research Outputs

Lam C.W., Law C.Y., To K.K., Cheung S.K., Lee K.C., Sze K.H., Leung K.F. and Yuen K.Y., NMR-based metabolomic urinalysis: A rapid screening test for urinary tract infection, In: Lam CW, Law CY, To KK, Cheung SK, Lee KC, Sze KH, Leung KF, Yuen KY, Clin Chim Acta. 2014, 436: 217–223.

Lam C.W., Law C.Y., To K.K.W., Cheung K.K., Lee K.C., Sze K.H. and Yuen K.Y., Springer Poster Prize For Outstanding Poster Presentation Of Research In The Field Of Metabolomics In The Metabolomics Society 2013 Conference , Metabolomics Society 2013 Conference . 2013.

Law C.Y., Cheung K.K. and Lam C.W., Performance Of High-resolution 1h Nuclear Magnetic Resonance Spectroscopy Analysis Versus Jaffe Reaction For Urinary Creatinine Quantification, International Symposium on Translating Omics Science to Clinical Applications 2013 (TOSCA'13). 2013.

To K.K.W., Lam C.W., Lee K.C., Yung K.Y., Law C.Y., Leung K.F., Lau K.C. and Chan S.F., Difference In The Metabolome Between Escherichia Coli Isolated From Patients With Pyelonephritis And Cholangitis, Metabolomics Society 2013 Conference . 2013.

To K.K.W., Lam C.W., Wong S.S.Y., Law C.Y., Lee K.C., Yung K.Y., Cheung K.K. and Chan S.F., Urine Metabolomics Profile Of Patients With Or Without Bacteremia, International Symposium on Translating Omics Science to Clinical Applications 2013 (TOSCA'13). 2013.

Researcher : Lee HHC

List of Research Outputs

Lee H.H.C., Mak C.M., Poon W.K.G., Wong K.Y. and Lam C.W., Cost-benefit analysis of Hyperphenylalaninemia Due to 6-Pyruvoyl-Tetrahydropterin Synthase (PTPS) Deficiency: For Consideration of Expanded Newborn Screening in Hong Kong, In: Lee HH, Mak CM, Poon GW, Wong KY, Lam CW, J Med Screen. 2014.

Lee H.H.C., Poon K.H., Lai C.K., Au K.M., Siu T.S., Lai J.P., Mak C.M., Yuen Y.P., Lam C.W. and Chan A.Y.W., Hyperornithinaemia-hyperammonaemia-homocitrullinuria syndrome: a treatable genetic liver disease warranting urgent diagnosis, In: Lee HH, Poon KH, Lai CK, Au KM, Siu TS, Lai JP, Mak CM, Yuen YP, Lam CW, Chan AY, Hong Kong Med J. 2014.

Lee H.H.C., Poon K.H., Lai C.K., Au K.M., Siu T.S., Lai J.P.S., Mak C.M., Yuen L.Y.P., Lam C.W. and Chan A.Y.W., Hyperornithinaemia-hyperammonaemia-homocitrullinuria syndrome: a treatable genetic liver disease warranting urgent diagnosis, In: Lee HH, Poon KH, Lai CK, Au KM, Siu TS, Lai JP, Mak CM, Yuen YP, Lam CW, Chan AY, Hong Kong Medical Journal. 2014, 20: 63-66.

Mak C.M., Lee H.H.C., Chan A.Y.W. and Lam C.W., Inborn errors of metabolism and expanded newborn screening: review and update, In: Mak CM, Lee HC, Chan AY, Lam CW, Crit Rev Clin Lab Sci. 2013.

Mak C.M., Lee H.H.C., Chan A.Y.W. and Lam C.W., Inborn errors of metabolism and expanded newborn screening: review and update, In: Mak CM, Lee HC, Chan AY, Lam CW, Critical Reviews in Clinical Laboratory Sciences. 2013, 50: 142-162.

Researcher : Lee KC

List of Research Outputs

Lam C.W., Law C.Y., To K.K., Cheung S.K., Lee K.C., Sze K.H., Leung K.F. and Yuen K.Y., NMR-based metabolomic urinalysis: A rapid screening test for urinary tract infection, In: Lam CW, Law CY, To KK, Cheung SK, Lee KC, Sze KH, Leung KF, Yuen KY, Clin Chim Acta. 2014, 436: 217–223.

Lam C.W., Law C.Y., To K.K.W., Cheung K.K., Lee K.C., Sze K.H. and Yuen K.Y., Springer Poster Prize For Outstanding Poster Presentation Of Research In The Field Of Metabolomics In The Metabolomics Society 2013 Conference , Metabolomics Society 2013 Conference . 2013.

Tam W.T., Chen J.H.K., Lau E.C., Ngan A.H., Fung K.S., Lee K.C., Lam C.W., Yuen K.Y., Lau S.K.P. and Woo P.C.Y., Misidentification of Aspergillus nomius and Aspergillus tamarii as Aspergillus flavus: characterization by internal transcribed spacer, β-Tubulin, and calmodulin gene sequencing, metabolic fingerprinting, and matrix-assisted laser desorption ionization-time of flight mass spectrometry, In: Tam EW, Chen JH, Lau EC, Ngan AH, Fung KS, Lee KC, Lam CW, Yuen KY, Lau SK, Woo PC, J Clin Microbiol. 2014.

To K.K.W., Lam C.W., Lee K.C., Yung K.Y., Law C.Y., Leung K.F., Lau K.C. and Chan S.F., Difference In The Metabolome Between Escherichia Coli Isolated From Patients With Pyelonephritis And Cholangitis, Metabolomics Society 2013 Conference . 2013.

To K.K.W., Lam C.W., Wong S.S.Y., Law C.Y., Lee K.C., Yung K.Y., Cheung K.K. and Chan S.F., Urine Metabolomics Profile Of Patients With Or Without Bacteremia, International Symposium on Translating Omics Science to Clinical Applications 2013 (TOSCA'13). 2013.

Researcher : Lee KW

Project Title:	The significance of Nucleophosmin (NPM) phosphorylation in the progression of hepatocellular carcinoma
Investigator(s):	Lee KW, Wong CM
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	09/2011
Completion Date:	02/2014

Project Title:	Clinical relevance and functional characterization of CD47 in hepatocellular carcinoma
Investigator(s):	Lee KW
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2012
Completion Date:	02/2014

Project Title:	Therapeutic targeting of liver cancer by use of monoclonal antibodies against CD47
Investigator(s):	Lee KW, Ng IOL
Department:	Pathology
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	11/2012
Completion Date:	10/2013

Project Title:	Therapeutic targeting of liver cancer by use of monoclonal antibodies against CD47
Investigator(s):	Lee KW, Ng IOL
Department:	Pathology
Source(s) of Funding:	Innovation and Technology Fund Internship Programme
Start Date:	11/2012

Project Title:	The role of Hepatitis B virus in regulation of liver cancer stem cells properties
Investigator(s):	Lee KW
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2013

Project Title:	Hepatitis B virus promotes hepatocarcinogenesi through regulation of stemness factors
Investigator(s):	Lee KW, Sze MF
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	10/2013

Project Title:	Clinical relevance and characterization of CD47 in hepatocellular carcinoma
Investigator(s):	Lee KW
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2013

Project Title:	The role of cancer-associated fibroblasts (CAFs) in hepatocellular carcinoma
Investigator(s):	Lee KW
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2014

List of Research Outputs

LO J., Ng I.O.L. and Lee K.W., CD47,a potential therapeutic target for hepatocellular carcinoma, Journal of Liver: Disease &Transplantation. 2013, 2: 2.

Lee K.W., Cancer associated fibroblasts regulate cancer stemcell-like features in hepatocellular carcinoma, Advanced Study Institute, University of Hong Kong. 2014.

Lee K.W., Identification of liver cancer stem cells for treatment of hepatocellular carcinoma, School of Biomedical Sciences, Faculty of Health at the Queensland University of Technology. 2014.

Researcher : Lee MF

List of Research Outputs

Au L.K.S., Wong C.C.L., Lee M.F., Wong C.M. and Ng I.O.L., EZH2-Mediated H3K27me3 Is Involved in Epigenetic Repression of Deleted in Liver Cancer 1 in Human Cancers, PLoS One. 2013, 8: e68226.

Hou J., Zhou Y., Zhang Y., Fan J., Zhou W., Ng I.O.L., Sun H., Qin L., Qiu S., Lee M.F., Lo C.M., Man K. and Cao X., Hepatic RIG-I predicts survival and interferon-α therapeutic response in hepatocellular carcinoma, Cancer Cell. 2014, 25(1): 49-63.

Sze M.F., Chu K.Y., Mak H.Y., Lee M.F. and Ng I.O.L., Proline-rich acidic protein 1 (PRAP1) is a novel interacting partner of MAD1 and has a suppressive role in mitotic checkpoint signalling in hepatocellular carcinoma., In: Peter A Hall, Journal of Pathology. Great Britain and Ireland, John Wiley & Sons, Ltd, 2014, 233(1): 51-60.

Researcher : Leung KC

List of Research Outputs

Chan S.C., Sharr W.W., Cheung T.T., Chan A.C.Y., Tsang S.H.Y., Chok K.S.H., Leung K.C. and Lo C.M., Retrohepatic vena cava deroofing in living donor liver transplantation for caudate hepatocellular carcinoma, Hepatobiliary & Pancreatic Diseases International. 2013, 12(5): 552-555.

Researcher : Leung KF

List of Research Outputs

Lam C.W., Law C.Y., To K.K., Cheung S.K., Lee K.C., Sze K.H., Leung K.F. and Yuen K.Y., NMR-based metabolomic urinalysis: A rapid screening test for urinary tract infection, In: Lam CW, Law CY, To KK, Cheung SK, Lee KC, Sze KH, Leung KF, Yuen KY, Clin Chim Acta. 2014, 436: 217–223.

Researcher : Leung RYY

List of Research Outputs

Tse E.W.C., Leung R.Y.Y. and Kwong Y.L., Invasive fungal infections after obinutuzumab monotherapy for refractory chronic lymphocytic leukemia, Annals of Hematology. 2014.

Researcher : Leung SY

Project Title:	Identification of BRAF mutation in various stages of colorectal carcinogenesis and its relationship with KRAS mutation
Investigator(s):	Leung SY, Yuen ST
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2002

Project Title:	Detail study of relationship of BRAF and KRAS mutation with microstatellite instability in colorectal cancer
Investigator(s):	Leung SY, Yuen ST
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2003

Project Title:	Genomic screening for potential tumour suppressors silenced by promoter hypermethylation in gastric adenocarcinomas using cDNA microarray
Investigator(s):	Leung SY, Yuen ST, Chu KM, Fung TWK, Lin MC
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2005

Project Title:	Outstanding Researcher Award 2006-2007
Investigator(s):	Leung SY
Department:	Pathology
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	11/2007

Project Title:	Research Output Prize (Faculty of Medicine)
Investigator(s):	Leung SY
Department:	Pathology
Source(s) of Funding:	Research Output Prize (in Faculty)
Start Date:	11/2007

Project Title:	Research Output Prize
Investigator(s):	Leung SY, Chan TL
Department:	Pathology
Source(s) of Funding:	Research Output Prize (in Faculty)
Start Date:	12/2009

Project Title:	Genomics study for new mechanism of tumour suppressor gene silencing by transcriptional interference in colorectal cancer
Investigator(s):	Leung SY, Chan TL, Lok S, Yuen ST
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2010

List of Research Outputs

Kuhmann C., LI C., Kloor M., Salou M., Weigel C., Schmidt C.R., Ng W.C.L., Tsui W.Y., Leung S.Y., Yuen S.T., Becker N., Weichenhan D., Plass C., Schmezer P., Chan T.L. and Popanda O., Altered regulation of DNA ligase IV activity by aberrant promoter DNA methylation and gene amplification in colorectal cancer., Hum Mol Genet. 2013, 23(8): 2043-54.

Leung S.Y., Colorectal Cancer – Molecular Pathology and Pathways of Cancer Development, Hong Kong Pathology Forum 2014, Department of Pathology, The University of Hong Kong. 2014.

Leung S.Y., Genomic Study of Gastric Cancer, International Conference of Advanced Molecular Technologies 2014 (Joint meeting with the 4th Asia Pacific Symposium on Advanced Molecular Technologies), Hong Kong . 2014.

Leung S.Y., Integrative Genomic Analysis of Gastric Cancer, Genomics and Stem Cell Based Therapies: Shaping the Future of Personalized Medicine, 2014 Nature China Conference, Guangzhou, China . 2014.

Leung S.Y., Journal Editorial Board Membership, Journal of Clinical Pathology. 2014.

Leung S.Y., Whole-genome Sequencing and Comprehensive Molecular Profiling of Gastric Cancer, The 9th National Gastric Cancer Academic Conference and the 2nd Sunlight Great Wall Cancer Academic Conference organized by Gastric Cancer Association, Beijing, China. 2014.

Leung S.Y., Whole-genome sequencing and integrative genomic analysis of gastric cancer, Ludwig Institute for Cancer Research, University of Oxford, Nuffield Department of Clinical Medicine, England. 2014.

Thompson B.A., Spurdle A.B., Plazzer J.P., Greenblatt M.S., Akagi K., Al-Mulla F., Bapat B., Bernstein I., Capellá G., den Dunnen J.T., du Sart D., Fabre A., Farrell M.P., Farrington S.M., Frayling I.M., Frebourg T., Goldgar D.E., Heinen C.D., Holinski-Feder E., Kohonen-Corish M., Robinson K.L., Leung S.Y., Martins A., Moller P., Morak M., Nystrom M., Peltomaki P., Pineda M., Qi M., Ramesar R., Rasmussen L.J., Royer-Pokora B., Scott R.J., Sijmons R., Tavtigian S.V., Tops C.M., Weber T., Wijnen J., Woods M.O., Macrae F., Genuardi M. and on behalf of I.N.S.I.G.H.T., Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database, Nat Genet. 2013, 46(2): 107-15.

Wang K., Yuen S.T., Xu J., LEE S.P., Yan H.H.N., Shi S.T., Siu H.C., Deng S., Chu K.M., Law S.Y.K., CHAN K.H., Chan A.S.Y., Tsui W.Y., Ho R.S.L., Chan K.W., Man J.L.K., Foglizzo V., Ng M.K., Chan A.S., Ching Y.P., Cheng H.W.G., Xie T., Fernandez J., Li V.S.W., Clevers H., Rejto P.A., Mao M. and Leung S.Y., Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer, Nature Genetics. 2014, 46(6): 573-582.

Researcher : Leung TKC

List of Research Outputs

Ng R.K., Kong C.T., So J.C.C., Lui W.C., Chan Y.F., Leung T.K.C., So C.K.C., Tsang H.M., Chan L.C. and Sham M.H., Epigenetic dysregulation of leukaemic HOX code in MLL-rearranged leukaemia mouse model, Journal of Pathology. John Wiley & Sons, Ltd, 2014, 232: 65-74.

Ng R.K., Kong C.T., So J.C.C., Lui W.C., Chan Y.F., Leung T.K.C., So C.K.C., Tsang H.M., Chan L.C. and Sham M.H., Epigenetic dysregulation of leukemic Hox code in MLL-rearranged leukemia mouse model, Keystone Symposia Conference: Cancer Epigenetics February 4-9, 2014, New Mexico, USA. 2014.

Researcher : Lin X

Project Title:	The role of Th17 cells in the development of experimental Sjogren's syndrome
Investigator(s):	Lin X, Lu L
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	01/2014

List of Research Outputs

Chu H., Zhou J., Wong H.Y.B., Li C., Cheng Z., Lin X., Poon K.M., Sun T., Lau C.Y., Chan J.F.W., To K.K.W., Chan K.H., Lu L., Zheng B. and Yuen K.Y., Productive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response. , Virology. 2014, 454-455: 197-205.

Researcher : Liu J

Project Title:	Identification and characterization of tumor-initiating cells in non-small cell lung carcinoma
Investigator(s):	Liu J, Wong MP
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	02/2013
Completion Date:	07/2014

List of Research Outputs

Lee V.H.F., Tin P.C., Choy T.S., Lam K.O., Choi C.W., Chung L.P., Tsang J.W.H., Ho P.P., Leung D.K., Ma E.S., Liu J., Shek T.W.H., Kwong D.L.W., Leung T.W. and Wong M.P., Association of Exon 19 and 21 EGFR Mutation Patterns with Treatment Outcome after First-Line Tyrosine Kinase Inhibitor in Metastatic Non-Small-Cell Lung Cancer, In: Lee VH, Tin VP, Choy TS, Lam KO, Choi CW, Chung LP, Tsang JW, Ho PP, Leung DK, Ma ES, Liu J, Shek TW, Kwong DL, Leung TW, Wong MP, J Thorac Oncol. 2013, 8(9):1148-55.

Liu J., XIAO Z., Tin P.C., Wang J.J., Sham M.H. and Wong M.P., Lung cancer tumorigenicity and drug resistance are maintained through ALDHhiCD44hi tumor initiating cells, Oncotarget. 2013, 4(10): 1686-99.

Researcher : Lo CLR

Project Title:	Study of testis-specific protein Y-encoded (TSPY) in hepatocellular carcinoma
Investigator(s):	Lo CLR, Ng IOL
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012

Project Title:	Identification of downstream targets of PIM1 in hepatocellular carcinoma
Investigator(s):	Lo CLR, Wong CCL
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2013

Project Title:	Asian Pacific Association for The Study of the Liver Annual Meeting 2014; A Clinicopathologic Analysis of CK19 Expression in Paired Primary and Recurrent/metastatic Hepatocellular Carcinoma
Investigator(s):	Lo CLR
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2014
Completion Date:	03/2014

Project Title:	Study of the downstream molecular mechanism of Sox9 in hepatocellular carcinoma
Investigator(s):	Lo CLR, Lee KW
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2014

List of Research Outputs

Chok K.S.H., Cheung T.T., Lo C.L.R., Chu S.K.F., Tsang S.H.Y., Chan A.C.Y., Sharr W.W., Fung J.Y.Y., Dai W.C., Chan S.C., Fan S.T. and Lo C.M., Pilot study of high-intensity focused ultrasound ablation as a bridging therapy for hepatocellular carcinoma patients wait-listed for liver transplantation, Liver Transplantation. 2014, Epub on 2014-04-18.

Fung J.Y.Y., Lo C.L.R., Chan S.C., Chok K.S.H., Sharr W.W., Dai W.C., Cheung T.T., Chan A.C.Y., Wong C.L.T., Ng I.O.L., Yuen R.M.F. and Lo C.M., Histological outcome after liver transplantation for chronic hepatitis B using oral antiviral therapy alone without hepatitis B immune globulin, The 2014 Joint International Congress of ILTS, ELITA & LICAGE. 2014.

Lo C.L.R. and Ng I.O.L., A Clinicopathologic Analysis of CK19 Expression in Paired Primary and Recurrent/metastatic Hepatocellular Carcinoma, APASL 2014.

Lo C.L.R., Clinicopathological session, Hong Kong Pathology Forum 2013. 2014.

Lo C.L.R., Clinicopathological session, SKLLR Annual Meeting 2013. 2013.

Researcher : Loong F

List of Research Outputs

Chan S.Y., Gill H., Hwang Y.Y.G., Sim J., Tse C.T.A., Loong F., Khong P.L., Tse E.W.C., Leung A.Y.H., Chim J.C.S., Lie A.K.W. and Kwong Y.L., Breakthrough invasive fungal diseases during echinocandin treatment in high-risk hospitalized hematologic patients, Annals of Hematology. 2014, 93(3): 493-498.

Chan T.S., Gill H., Hwang Y.Y., Sim P.Y.J., Tse A.C., Loong F., Khong P.L., Tse E.W.C., Leung A.Y.H., Chim J.C.S., Lie A.K.W. and Kwong Y.L., Breakthrough invasive fungal diseases during echinocandin treatment in high-risk hospitalized hematologic patients, Ann Hematol. 2013, Epub ahead of print.

Researcher : Lu L

Project Title:	Plasma cell development and its regulation in autoimmunity
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2007

Project Title:	The role of IL-17 in modulating B cell functions duringin anti-viral immunity against H5N1 influenza infection in mice
Investigator(s):	Lu L, Zheng B
Department:	Pathology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2011

Project Title:	Roles of B cells in autoimmunity
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	Croucher Senior Research Fellowships in Natural Sciences, Technology and Medicine
Start Date:	01/2012
Completion Date:	02/2014

Project Title:	Roles of leptin in regulating T cell function and autoimmune pathogenesis
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013

Project Title:	Characterization of regulatory B cell and its functional implication in autoimmune diabetes
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2013
Completion Date:	05/2014

Project Title:	5th International Conference on Crossroads between Innate and Adaptive Immunity; Roles of regulatory B cells in autoimmune arthritis
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2013
Completion Date:	09/2013

Project Title:	B-1 cell response and its regulation during influenza virus infection
Investigator(s):	Lu L, Ko KH
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	01/2014

Project Title:	Outstanding Researcher Award 2012-13
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	Outstanding Researcher Award
Start Date:	01/2014

Project Title:	The role of B1 cells in the pathogenesis of autoimmune arthritis
Investigator(s):	Lu L
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2014

List of Research Outputs

Chu H., Zhou J., Wong H.Y.B., Li C., Cheng Z., Lin X., Poon K.M., Sun T., Lau C.Y., Chan J.F.W., To K.K.W., Chan K.H., Lu L., Zheng B. and Yuen K.Y., Productive replication of Middle East respiratory syndrome coronavirus in monocyte-derived dendritic cells modulates innate immune response. , Virology. 2014, 454-455: 197-205.

ZHANG N., LIN Y., Chen M., LEUNG H.C., Chan C.S., Poon K.M., Zhou J., Cheung C.Y., Lu L. and Zheng B., Pandemic A/H1N1 2009 Influenza Virus-like Particles Elicited Higher and Broader Immune Responses than the Commercial Panenza Vaccine., J Pharm Pharmaco. 2014, 2(2014): 50-58.

Researcher : Lui WC

List of Research Outputs

Lui W.C., Chan Y.F., Chan L.C. and Ng R.K., Cytokine combinations on the potential for ex vivo expansion of murine hematopoietic stem cells, Cytokine. Elsevier, 2014, 68: 127-132.

Ng R.K., Kong C.T., So J.C.C., Lui W.C., Chan Y.F., Leung T.K.C., So C.K.C., Tsang H.M., Chan L.C. and Sham M.H., Epigenetic dysregulation of leukaemic HOX code in MLL-rearranged leukaemia mouse model, Journal of Pathology. John Wiley & Sons, Ltd, 2014, 232: 65-74.

Ng R.K., Kong C.T., So J.C.C., Lui W.C., Chan Y.F., Leung T.K.C., So C.K.C., Tsang H.M., Chan L.C. and Sham M.H., Epigenetic dysregulation of leukemic Hox code in MLL-rearranged leukemia mouse model, Keystone Symposia Conference: Cancer Epigenetics February 4-9, 2014, New Mexico, USA. 2014.

Researcher : MAUROO NF

List of Research Outputs

CHAN C.Y., OR K.M., MAUROO N.F., Fernando N. and Karczmarski L., Tough living in Hong Kong? Indo-Pacific humpback dolphins with skin disorders and traumatic mutilations in a highly developed estuarine system. , 20th Biennial Conference on the Biology of Marine Mammals, Dunedin, New Zealand. 9-13 Dec . 2013.

Researcher : Ma SKY

Project Title:	Functional and molecular characterization of TP53INP1 as a novel metastasis suppressor in hepatocellular carcinoma
Investigator(s):	Ma SKY
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	03/2012
Completion Date:	02/2014

Project Title:	Centre for MicroRNA Study - Basic Research and Clinical Potentials in Cancer
Investigator(s):	Ma SKY, Wong AST
Department:	Pathology
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	06/2012

Project Title:	Characterization and clinical evaluation of the metastasis-suppressing function of TP53INP1 in hepatocellular carcinoma
Investigator(s):	Ma SKY
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2012

Project Title:	Hepatitis B virus promotes hepatocarcinogenesis through induction of CD133+ cancer stem cells/tumor-initiating cells
Investigator(s):	Ma SKY, Guan X
Department:	Clinical Oncology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	01/2013

Project Title:	Epigenetic modulation of CD133+ liver cancer stem cells by chromatin-modifying enzymes
Investigator(s):	Ma SKY
Department:	Clinical Oncology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2013
Completion Date:	04/2014

Project Title:	Significance of Annexin A3 in CD133+ Cancer-Initiating Cells-Driven Hepatocellular Carcinoma
Investigator(s):	Ma SKY, Chan KW
Department:	Clinical Oncology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2013

Project Title:	Outstanding Young Researcher Award 2012-13
Investigator(s):	Ma SKY
Department:	Anatomy
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	01/2014

Project Title:	American Association for Cancer Research Annual Meeting 2014; Annexin A3 is a therapeutic target for CD133+ liver cancer stem cells
Investigator(s):	Ma SKY
Department:	Anatomy
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2014
Completion Date:	04/2014

Project Title:	A multidisciplinary study on hepatic cancer stem cells
Investigator(s):	Ma SKY
Department:	Anatomy
Source(s) of Funding:	Croucher Innovation Awards
Start Date:	04/2014

Project Title:	The use of anti-annexin A3 monoclonal antibody for the treatment of liver cancer
Investigator(s):	Ma SKY
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	05/2014

Project Title:	miR-1246 and Wnt/β-catenin interaction in the control of CD133+ liver cancer stem cells driven hepatocellular carcinoma
Investigator(s):	Ma SKY
Department:	Anatomy
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2014

Researcher : Mak CM

List of Research Outputs

Lee H.H.C., Mak C.M., Poon W.K.G., Wong K.Y. and Lam C.W., Cost-benefit analysis of Hyperphenylalaninemia Due to 6-Pyruvoyl-Tetrahydropterin Synthase (PTPS) Deficiency: For Consideration of Expanded Newborn Screening in Hong Kong, In: Lee HH, Mak CM, Poon GW, Wong KY, Lam CW, J Med Screen. 2014.

Lee H.H.C., Poon K.H., Lai C.K., Au K.M., Siu T.S., Lai J.P., Mak C.M., Yuen Y.P., Lam C.W. and Chan A.Y.W., Hyperornithinaemia-hyperammonaemia-homocitrullinuria syndrome: a treatable genetic liver disease warranting urgent diagnosis, In: Lee HH, Poon KH, Lai CK, Au KM, Siu TS, Lai JP, Mak CM, Yuen YP, Lam CW, Chan AY, Hong Kong Med J. 2014.

Lee H.H.C., Poon K.H., Lai C.K., Au K.M., Siu T.S., Lai J.P.S., Mak C.M., Yuen L.Y.P., Lam C.W. and Chan A.Y.W., Hyperornithinaemia-hyperammonaemia-homocitrullinuria syndrome: a treatable genetic liver disease warranting urgent diagnosis, In: Lee HH, Poon KH, Lai CK, Au KM, Siu TS, Lai JP, Mak CM, Yuen YP, Lam CW, Chan AY, Hong Kong Medical Journal. 2014, 20: 63-66.

Mak C.M., Lee H.H.C., Chan A.Y.W. and Lam C.W., Inborn errors of metabolism and expanded newborn screening: review and update, In: Mak CM, Lee HC, Chan AY, Lam CW, Crit Rev Clin Lab Sci. 2013.

Mak C.M., Lee H.H.C., Chan A.Y.W. and Lam C.W., Inborn errors of metabolism and expanded newborn screening: review and update, In: Mak CM, Lee HC, Chan AY, Lam CW, Critical Reviews in Clinical Laboratory Sciences. 2013, 50: 142-162.

Researcher : Man JLK

List of Research Outputs

Wang K., Yuen S.T., Xu J., LEE S.P., Yan H.H.N., Shi S.T., Siu H.C., Deng S., Chu K.M., Law S.Y.K., CHAN K.H., Chan A.S.Y., Tsui W.Y., Ho R.S.L., Chan K.W., Man J.L.K., Foglizzo V., Ng M.K., Chan A.S., Ching Y.P., Cheng H.W.G., Xie T., Fernandez J., Li V.S.W., Clevers H., Rejto P.A., Mao M. and Leung S.Y., Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer, Nature Genetics. 2014, 46(6): 573-582.

Researcher : Man PS

List of Research Outputs

Khongkow M., Olmos Y., Gong C., Gomes A.R., Monteiro L.J., Yague E., Cavaco T.B., Khongkow P., Man P.S. and Laohasinnarong S., SIRT6 modulates paclitaxel and epirubicin resistance and survival in breast cancer, Carcinogenesis. 2013, 34: 1476-1486.

Researcher : Mao X

List of Research Outputs

Ko F.C.F., Yeung Y.S., Mao X. and Yam J.W.P., Novel RhoGAP independent pathway of tumor suppressor DLC1 regulates cancer invasion and metastasis, 2014 American Association for Cancer Research Annual Meeting. 2014.

Researcher : Nanji AA

Project Title:	10th Congress of the International Society for Biomedical Research on Alcoholism Mechanisms of Apoptosis in Alcoholic Liver Disease
Investigator(s):	Nanji AA
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	07/2000

Researcher : Ng IOL

Project Title:	Characterization of the roles of hepatitis B virus X protein in liver cancer
Investigator(s):	Ng IOL, Chan DW
Department:	Pathology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	09/2006

Project Title:	Outstanding Research Student Supervisor Award 2007-2008
Investigator(s):	Ng IOL
Department:	Pathology
Source(s) of Funding:	Outstanding Research Student Supervisor Award
Start Date:	10/2008

Project Title:	Molecular Pathology of Liver Cancer - a Multidisciplinary Study
Investigator(s):	Ng IOL, Cheung ST, Ching YP, Guan X, Jin D, Lee KW, Poon RTP, Wong CM
Department:	Pathology
Source(s) of Funding:	Collaborative Research Fund (CRF) - Group Research Project
Start Date:	05/2010
Completion Date:	10/2013

Project Title:	Significance of cten dysregulation in hepatocarcinogenesis and cancer metastasis
Investigator(s):	Ng IOL, Yam JWP
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2011
Completion Date:	12/2013

Project Title:	The Use of Anti-DKK1 (anti-Dickkopf-1) Monoclonal Antibody for Treatment of Liver Cancer
Investigator(s):	Ng IOL, Tung KK
Department:	Pathology
Source(s) of Funding:	Innovation and Technology Support Programme (Tier 3)
Start Date:	09/2011

Project Title:	Significance of RhoE dysregulation in liver cancer and metastasis
Investigator(s):	Ng IOL, Chan LK, Wong CM
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2011

Project Title:	Dissection of DLC1/Rho/ROCK2 signaling pathway in liver cancer
Investigator(s):	Ng IOL, Chan LK
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012
Completion Date:	06/2014

Project Title:	Dissecting the gender disparity of hepatocellular carcinoma: Roles of HBV X protein and androgen receptor
Investigator(s):	Ng IOL, Chiu YT
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2013

Project Title:	Role of hypoxia-inducible miR-210 in liver cancer
Investigator(s):	Ng IOL
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	05/2013

Project Title:	Cancer Biology
Investigator(s):	Ng IOL
Department:	Pathology
Source(s) of Funding:	Croucher Summer Courses
Start Date:	08/2013

Project Title:	ILCA 2013 Annual Conference and ILCA-EASL-NCI-AASLD workshop on molecular classification and biomarkers in HCC; A talk on “HCC classification based on pathological markers"
Investigator(s):	Ng IOL
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2013
Completion Date:	09/2013

Project Title:	The role of Lgr5 in liver cancer
Investigator(s):	Ng IOL
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014

Project Title:	Liver cancer research - From bench to translational applications
Investigator(s):	Ng IOL
Department:	Pathology
Source(s) of Funding:	Croucher Senior Medical Research Fellowships
Start Date:	01/2014

Project Title:	Delineation of the role of RSK2 and their natural mutants in liver cancer
Investigator(s):	Ng IOL
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2014

List of Research Outputs

Au L.K.S., Wong C.C.L., Lee M.F., Wong C.M. and Ng I.O.L., EZH2-Mediated H3K27me3 Is Involved in Epigenetic Repression of Deleted in Liver Cancer 1 in Human Cancers, PLoS One. 2013, 8: e68226.

Fung J.Y.Y., Lo C.L.R., Chan S.C., Chok K.S.H., Sharr W.W., Dai W.C., Cheung T.T., Chan A.C.Y., Wong C.L.T., Ng I.O.L., Yuen R.M.F. and Lo C.M., Histological outcome after liver transplantation for chronic hepatitis B using oral antiviral therapy alone without hepatitis B immune globulin, The 2014 Joint International Congress of ILTS, ELITA & LICAGE. 2014.

Hou J., Zhou Y., Zhang Y., Fan J., Zhou W., Ng I.O.L., Sun H., Qin L., Qiu S., Lee M.F., Lo C.M., Man K. and Cao X., Hepatic RIG-I predicts survival and interferon-α therapeutic response in hepatocellular carcinoma, Cancer Cell. 2014, 25(1): 49-63.

Jing Y., Jia D., Wong C.M., Ng I.O.L., Zhang Z., Liu L., Wang Q., Zhao F., Li J., Yao M., Wu X. and He X., SERPINA5 inhibits tumor cell migration by modulating the fibronectin-integrin β1 signaling pathway in hepatocellular carcinoma, Mol Oncol. 2014, 8: 366.

LO J., Ng I.O.L. and Lee K.W., CD47,a potential therapeutic target for hepatocellular carcinoma, Journal of Liver: Disease &Transplantation. 2013, 2: 2.

Lo C.L.R. and Ng I.O.L., A Clinicopathologic Analysis of CK19 Expression in Paired Primary and Recurrent/metastatic Hepatocellular Carcinoma, APASL 2014.

Ng I.O.L., HCC classification based on pathological markers, International Liver Cancer Association 7th Annual Conference - ILCA-EASL-NCI-AASLD Workshop on Molecular Classification and Biomarkers in HCC, Washington, DC, USA. 2013.

Ng I.O.L., Liver Cancer Stem Cells, 2013 Shanghai International Symposium on Cancer Stem Cells, Shanghai, China. 2013.

Ng I.O.L., Recent updates in liver cancer stem cells, The 8th IAP Asia Pacific Congress, Busan, South Korea. 2013.

Sze M.F., Chu K.Y., Mak H.Y., Lee M.F. and Ng I.O.L., Proline-rich acidic protein 1 (PRAP1) is a novel interacting partner of MAD1 and has a suppressive role in mitotic checkpoint signalling in hepatocellular carcinoma., In: Peter A Hall, Journal of Pathology. Great Britain and Ireland, John Wiley & Sons, Ltd, 2014, 233(1): 51-60.

Wong C.C.L. and Ng I.O.L., Lysyl oxidase-like 2 promotes hepatocellular carcinoma metastasis by remodeling the tumor and metastatic microenvironments, In: American Association for Cancer Research, American Association for Cancer Research (AACR) 105th Annual Meeting. 2014.

Wong C.C.L., Kai A.K.L. and Ng I.O.L., The Impact Of Hypoxia In Hepatocellular Carcinoma Metastasis, Frontiers Of Medicine. 2014.

Researcher : Ng MK

List of Research Outputs

Wang K., Yuen S.T., Xu J., LEE S.P., Yan H.H.N., Shi S.T., Siu H.C., Deng S., Chu K.M., Law S.Y.K., CHAN K.H., Chan A.S.Y., Tsui W.Y., Ho R.S.L., Chan K.W., Man J.L.K., Foglizzo V., Ng M.K., Chan A.S., Ching Y.P., Cheng H.W.G., Xie T., Fernandez J., Li V.S.W., Clevers H., Rejto P.A., Mao M. and Leung S.Y., Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer, Nature Genetics. 2014, 46(6): 573-582.

Researcher : Ng RK

Project Title:	The functional roles of histone H3K9 demethylase Jmjd2 family in determination of trophoblast lineages
Investigator(s):	Ng RK, Lee CYL
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2010

Project Title:	Role of RUNX1 in the establishment of leukemic stem cells in MLL-rearranged leukemia
Investigator(s):	Ng RK
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012
Completion Date:	06/2014

Project Title:	The functional role of epigenetic memory in the differentiation plasticity of induced pluripotent stem cells
Investigator(s):	Ng RK
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013

Project Title:	Function of PRMT1 in the establishment of leukemia stem cell
Investigator(s):	Ng RK
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2013

Project Title:	The role of PRMT1 in activation of leukemia stem cell program in MLL-rearranged leukemia
Investigator(s):	Ng RK, Yiu SM, Chan LC
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2014

Project Title:	Cancer Epigenetics; Epigenetic dysregulation of leukemic Hox code in MLL-rearranged leukemia mouse model
Investigator(s):	Ng RK
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	02/2014
Completion Date:	02/2014

Project Title:	Function of polycomb protein Bmi-1 in hematopoietic Wnt signaling pathway
Investigator(s):	Ng RK
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2014

List of Research Outputs

Lui W.C., Chan Y.F., Chan L.C. and Ng R.K., Cytokine combinations on the potential for ex vivo expansion of murine hematopoietic stem cells, Cytokine. Elsevier, 2014, 68: 127-132.

Ng R.K., DNA replication and transcription, In: Department of Biochemistry, The University of Hong Kong , Department of Biochemistry, The University of Hong Kong. 2014.

Ng R.K., Epigenetic barrier in differentiation of mouse embryonic stem cells towards trophoblast lineage, International Society For Stem Cell Research (ISSCR) 12th Annual Meeting June 18-21, 2014, Vancouver, Canada. 2014.

Ng R.K., Kong C.T., So J.C.C., Lui W.C., Chan Y.F., Leung T.K.C., So C.K.C., Tsang H.M., Chan L.C. and Sham M.H., Epigenetic dysregulation of leukaemic HOX code in MLL-rearranged leukaemia mouse model, Journal of Pathology. John Wiley & Sons, Ltd, 2014, 232: 65-74.

Ng R.K., Kong C.T., So J.C.C., Lui W.C., Chan Y.F., Leung T.K.C., So C.K.C., Tsang H.M., Chan L.C. and Sham M.H., Epigenetic dysregulation of leukemic Hox code in MLL-rearranged leukemia mouse model, Keystone Symposia Conference: Cancer Epigenetics February 4-9, 2014, New Mexico, USA. 2014.

Ng R.K., Roles of Epigenetic Regulation in Stem Cell and Cancer Biology, In: Department of Biochemistry, The University of Hong Kong, Department of Biochemistry, The University of Hong Kong. 2014.

Wang X., Ng R.K., Ming X., Zhang W., Chen L., Chu A.C.Y., Pang R.W.C., Lo C.M., Tsao G.S.W., Liu X., Poon R.T.P. and Fan S.T., Epigenetic regulation of pluripotent genes mediates stem cell features in human hepatocellular carcinoma and cancer cell lines, PLoS One. 2013, 8(9): e72435.

Researcher : Ng WCL

List of Research Outputs

Kuhmann C., LI C., Kloor M., Salou M., Weigel C., Schmidt C.R., Ng W.C.L., Tsui W.Y., Leung S.Y., Yuen S.T., Becker N., Weichenhan D., Plass C., Schmezer P., Chan T.L. and Popanda O., Altered regulation of DNA ligase IV activity by aberrant promoter DNA methylation and gene amplification in colorectal cancer., Hum Mol Genet. 2013, 23(8): 2043-54.

Researcher : Nicholls JM

Project Title:	Susceptibility of the upper respiratory tract to influenza virus infection following desialyation
Investigator(s):	Nicholls JM, Chan MCW, Kwong DLW
Department:	Pathology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2009

Project Title:	Prevention and treatment of swine origin influenza virus (S-OIV) though the use of interferon - an in vivo and ex vivo study
Investigator(s):	Nicholls JM
Department:	Pathology
Source(s) of Funding:	Research Fund for the Control of Infectious Diseases - Full Grants
Start Date:	01/2010

Project Title:	Options for Control of Influenza VIII; Tropism of human and infleunza virus infection in the human respiratory tract using ex vivo tissues
Investigator(s):	Nicholls JM
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	09/2013
Completion Date:	09/2013

Project Title:	Molecular determinants of H9N2 virus haemagglutinin and neuraminidase affecting virus tropism for the human and swine respiratory tract
Investigator(s):	Nicholls JM, Chan WY, Mok KP
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	11/2013

List of Research Outputs

Bui H.T., Nicholls J.M., Peiris J.S.M., Chan M.C.W. and Chan W.Y., Influenza B viruses in swine: virus tropism in swine respiratory organ explant cultures., Options for the Control of Influenza VIII. 2013.

Chan M.C.W., Chan W.Y., Chan L.Y., Mok K.P., Hui P.Y., Fong J.H.M., Tao K.P., Poon L.L.M., Nicholls J.M., Guan Y. and Peiris J.S.M., Tropism and innate host responses of a novel avian influenza A H7N9 virus: an analysis of ex-vivo and in-vitro cultures of the human respiratory tract, In: Chan MC, Chan RW, Chan LL, Mok CK, Hui KP, Fong JH, Tao KP, Poon LL, Nicholls JM, Guan Y, Peiris JM, Lancet Respir Med. 2013, 1: 534-42.

Chan W.Y., Karamanska R., Van Poucke S., Van Reeth K., Chan W.W., Chan M.C.W., Dell A., Peiris J.S.M., Haslam S.M., Guan Y. and Nicholls J.M., Infection of swine ex vivo tissues with avian viruses including H7N9 and correlation with glycomic analysis, In: Chan RW, Karamanska R, Van Poucke S, Van Reeth K, Chan IW, Chan MC, Dell A, Peiris JS, Haslam SM, Guan Y, Nicholls JM, Influenza Other Respir Viruses. Wiley-Blackwell, 2013, 7: 1269-1282.

Chow J.P., Man W.Y., Mao M., Chen H., Cheung M.F.F., Nicholls J.M., Tsao G.S.W., Lung M.L. and Poon R.Y., Poly(ADP-ribose) polymerase 1 is overexpressed in nasopharyngeal carcinoma and its inhibition enhances radiotherapy, Molecular Cancer Therapeutics. 2013, 12(11): 2517-28.

Doak S.A., Li O.T.W., Mak P.W., Mok K.P., Nicholls J.M., Guan Y., Waldmann T.A., Peiris J.S.M., Perera L.P. and Poon L.L.M., IL-15 adjuvanted multivalent vaccinia-based universal influenza vaccine requires CD4+ T cells for heterosubtypic protection, In: Valkenburg SA, Li OT, Mak PW, Mok CK, Nicholls JM, Guan Y, Waldmann TA, Peiris JS, Perera LP, Poon LL, Proc Natl Acad Sci U S A. 2014.

Garcia J.C., Lai J.C.C., Haselhorst T., Choy K.T., Yen H., Peiris J.S.M., Itzstein M.V. and Nicholls J.M., Investigation of the binding and cleavage characteristics of N1 neuraminidases from avian, seasonal, and pandemic influenza viruses using saturation transfer difference nuclear magnetic resonance, Influenza and Other Respiratory Viruses. 2014, 8(2): 235-42.

Leung G.K.K. and Nicholls J.M., Effect of clinical context on simulator-based assessment of blood pressure taking - a pilot randomized study, In: Leung GK, Nicholls JM, Med Teach. 2014.

Leung G.K.K. and Nicholls J.M., Effect of clinical context on simulator-based assessment of blood pressure taking - a pilot randomized study, Medical Teacher. 2014, 36(2): 177-179.

Mok K.P., Lee H.Y.H., Lestra M., Nicholls J.M., Chan M.C.W., Sia S.F., Zhu H., Poon L.L.M., Guan Y. and Peiris J.S.M., Amino acid substitutions in polymerase basic protein 2 gene contribute to the pathogenicity of the novel A/H7N9 Influenza virus in mammalian hosts., Journal of Virology. 2014, 88(6): 3568-76.

Mok K.P., Lee H.Y.H., Chan M.C.W., Sia S.F., Lestra M., Nicholls J.M., Zhu H., Guan Y. and Peiris J.S.M., Pathogenicity of the novel A/H7N9 influenza virus in mice, mBio. 2013, 4(4): e00362-13.

Nicholls J.M., Editor, In: Nicholls JM, Infection and Chemotherapy. 2014.

Nicholls J.M., New data on the host restriction of influenza virus transmission between species, In: Nicholls JM, 2014 TEPIK/Korean Society for Zoonoses Symposium, Seoul, Korea. June 10th 2014. 2014.

Peng P., Liu H., Gong J., Nicholls J.M. and Li X.C., A facile synthesis of sialylated oligolactosamine glycans from lactose via the Lafont intermediate, Chemical Science. 2014, 5: 3634-3639.

Researcher : Shek TWH

List of Research Outputs

Chan C.L., Ho R.S., Shek T.W.H. and Kwong A., Diabetic mastopathy, The Breast Journal. 2013, 19: 533-538.

Cheung J.P.Y., Tsang H.H.L., Ho K.W.Y., Lam Y.L. and Shek T.W.H., Atypical Manifestation Of Igg4-related Disease Mimicking Musculoskeletal Infection, Journal Of Orthopaedic Science. 2014.

Lee V.H.F., Tin P.C., Choy T.S., Lam K.O., Choi C.W., Chung L.P., Tsang J.W.H., Ho P.P., Leung D.K., Ma E.S., Liu J., Shek T.W.H., Kwong D.L.W., Leung T.W. and Wong M.P., Association of Exon 19 and 21 EGFR Mutation Patterns with Treatment Outcome after First-Line Tyrosine Kinase Inhibitor in Metastatic Non-Small-Cell Lung Cancer, In: Lee VH, Tin VP, Choy TS, Lam KO, Choi CW, Chung LP, Tsang JW, Ho PP, Leung DK, Ma ES, Liu J, Shek TW, Kwong DL, Leung TW, Wong MP, J Thorac Oncol. 2013, 8(9):1148-55.

Researcher : Siu CWK

List of Research Outputs

Cheung K.M., Lam C.W., Chan Y.K., Siu C.W.K. and Yong L., Atypical focal cortical dysplasia in a patient with Cowden syndrome, In: Cheung KM, Lam CW, Chan YK, Siu WK, Yong L, Hong Kong Med J. 2014.

Researcher : Siu HC

List of Research Outputs

Wang K., Yuen S.T., Xu J., LEE S.P., Yan H.H.N., Shi S.T., Siu H.C., Deng S., Chu K.M., Law S.Y.K., CHAN K.H., Chan A.S.Y., Tsui W.Y., Ho R.S.L., Chan K.W., Man J.L.K., Foglizzo V., Ng M.K., Chan A.S., Ching Y.P., Cheng H.W.G., Xie T., Fernandez J., Li V.S.W., Clevers H., Rejto P.A., Mao M. and Leung S.Y., Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer, Nature Genetics. 2014, 46(6): 573-582.

Researcher : Siu KY

Project Title:	Effects of folate and folate receptor on ovarian and endometrial cancer: an in vitro study
Investigator(s):	Siu KY, Cheung ANY
Department:	Pathology
Source(s) of Funding:	American Institute for Cancer Research (AICR) - General Award
Start Date:	07/2006

Project Title:	p21-activated kinase 4: a prognostic and therapeutic target for ovarian carcinoma?
Investigator(s):	Siu KY, Cheung ANY, Ngan HYS
Department:	Pathology
Source(s) of Funding:	The Hong Kong Anti-Cancer Society (HKACS) - General Award
Start Date:	10/2007

List of Research Outputs

Zhao F., Siu K.Y., Wong G.W., Wong E.S.Y., Jiang L.L., Tam K.F., Ngan H.Y.S., Le X.F., Lam E.W.F. and Cheung A.N.Y., Role of FOXM1 in ovarian carcinogenesis, In: Zhao F, Siu MK, Wong OG, Wong ES, Jiang LL, Tam KF, Ngan HY, Le XF, Lam EWF, Cheung AN, AACR conference Advances in Ovarian Cancer Research: From Concept to Clinic. September 18-21, 2013. Miami, USA. Proceedings of the American Association for Cancer Research. 2013.

Researcher : So CKC

List of Research Outputs

Ng R.K., Kong C.T., So J.C.C., Lui W.C., Chan Y.F., Leung T.K.C., So C.K.C., Tsang H.M., Chan L.C. and Sham M.H., Epigenetic dysregulation of leukaemic HOX code in MLL-rearranged leukaemia mouse model, Journal of Pathology. John Wiley & Sons, Ltd, 2014, 232: 65-74.

Ng R.K., Kong C.T., So J.C.C., Lui W.C., Chan Y.F., Leung T.K.C., So C.K.C., Tsang H.M., Chan L.C. and Sham M.H., Epigenetic dysregulation of leukemic Hox code in MLL-rearranged leukemia mouse model, Keystone Symposia Conference: Cancer Epigenetics February 4-9, 2014, New Mexico, USA. 2014.

Researcher : So JCC

Project Title:	Establishment of a Molecular Strategy for Direct Genotypic Characterisation of Moderate and Severe Haemophilia A in Hong Kong
Investigator(s):	So JCC
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	05/2012
Completion Date:	05/2015

Project Title:	XXVIIth International Symposium on Technological Innovations in Laboratory Haematology; A Comparison of High Resolution Melting, Allele-specific Priming and Sanger Sequencing for the Detection of BRAFV600E Mutation in Hairy Cell Leukaemia from Different Haematological Specimens
Investigator(s):	So JCC
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2014
Completion Date:	05/2014

Project Title:	Determination of the eaxct copy number variation in alpha globin genes and investigation of its effect on the phenotype of beta thalassaemia intermedia
Investigator(s):	So JCC
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2014

List of Research Outputs

Ip H.W. and So J.C.C., Diagnosis and prevention of thalassemia, Crit Rev Clin Lab Sci. 2013, 50(6): 125-41.

NG H.Y., Wan T.S.K., So J.C.C. and Chim J.C.S., Epigenetic inactivation of DAPK1, p14ARF, mir-34a and -34b/c in acute promyelocytic leukemia, Journal of Clinical Pathology. 2014, 67(6): 626-631.

Ng R.K., Kong C.T., So J.C.C., Lui W.C., Chan Y.F., Leung T.K.C., So C.K.C., Tsang H.M., Chan L.C. and Sham M.H., Epigenetic dysregulation of leukaemic HOX code in MLL-rearranged leukaemia mouse model, Journal of Pathology. John Wiley & Sons, Ltd, 2014, 232: 65-74.

Ng R.K., Kong C.T., So J.C.C., Lui W.C., Chan Y.F., Leung T.K.C., So C.K.C., Tsang H.M., Chan L.C. and Sham M.H., Epigenetic dysregulation of leukemic Hox code in MLL-rearranged leukemia mouse model, Keystone Symposia Conference: Cancer Epigenetics February 4-9, 2014, New Mexico, USA. 2014.

So J.C.C., Chan A. and Chung L.P., A Comparison of high resolution melting, allele-specific priming and Sanger sequencing for the detection of BRAFV600E mutation in hairy cell leukaemia from different haematological specimens, XXVII Symposium on Technological Innovations in Laboratory Hematology, The Netherlands. 2014.

So J.C.C., Genetics and diagnosis of haemophilia, Faculty of Health Sciences, Macau University of Science and Technology, Macau. 2014.

So J.C.C., Chan A.Y. and Lam C.C.K., Novel point mutation of the α2-globin gene (HBA2) and a rare 2.4 kb deletion of the α1-globin gene (HBA1), identified in two chinese patients with Hb H disease, Hemoglobin. 2014, 38(3): 213-5.

So J.C.C., The significance of dyserythropoiesis, Br J Haematol. 2013, 164(3): 313.

So J.C.C., Type and screen, St. Paul’s Hospital, Hong Kong . 2013.

Wong K.Y., Wan T.S.K., So J.C.C. and Chim J.C.S., Establishment of a Chinese human multiple myeloma cell line: MMLAL, Cancer Cell Int. . 2013, 13(1): 122.

Researcher : Srivastava G

Project Title:	Identification of direct and indirect targets of the del 6q putative tumor suppressor PRDM1 gene in NK cells, and the role of the aberrant expression of these PRDM1 downstream target genes in the pathogenesis of NK-cell malignancies
Investigator(s):	Srivastava G, Liang RHS
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2009

Project Title:	Tumor suppressor role of PRKCBP1, a novel translocation partner of IGH gene, in the pathogenesis of gastric and other B-cell non-Hodgkin’s lymphomas
Investigator(s):	Srivastava G
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	04/2011

Project Title:	Molecular features and functional consequences of a novel recurrent t(14;20)(q32;q13.12)/IGHS?PRKCBP1 translocation in gastric and other B-cell non-Hodgkins lymphomas
Investigator(s):	Srivastava G
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2011

Project Title:	Effect of t(11;14)(p13;q32) translocation on the expression of PDHX, the telomeric gene on chromosome 11p13, in GCB-derived lymphomas
Investigator(s):	Srivastava G
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2012

Project Title:	The roles of FOXP1 and its N-terminally truncated isoforms in the pathogenesis of diffuse large B-cell lymphoma
Investigator(s):	Srivastava G, Choi WL
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2012

Project Title:	Epigenetic silencing of the lymphocyte homing receptor CD44 in reactive germinal center B cells (GCB) and its activation in GCB-derived lymphomas by aberrant promoter hypomethylation
Investigator(s):	Srivastava G, Choi WL
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2012

Researcher : Sze MF

Project Title:	The characterizations of Ubiquitin-Conjugating Enzyme E2O (UBE2O) in mitotic checkpoint control via-interaction with MAD1 in hepatocellular carcinoma
Investigator(s):	Sze MF, Ng IOL
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	03/2014

List of Research Outputs

Sze M.F., Chu K.Y., Mak H.Y., Lee M.F. and Ng I.O.L., Proline-rich acidic protein 1 (PRAP1) is a novel interacting partner of MAD1 and has a suppressive role in mitotic checkpoint signalling in hepatocellular carcinoma., In: Peter A Hall, Journal of Pathology. Great Britain and Ireland, John Wiley & Sons, Ltd, 2014, 233(1): 51-60.

Researcher : TEY SK

List of Research Outputs

TEY S.K. and Yam J.W.P., Role of nuclear Met in hepatocellular carcinoma, 2014 American Association for Cancer Research Annual Meeting. 2014.

Researcher : Tam S

List of Research Outputs

Cho S.Y., Siu T.S., Ma O., Tam S. and Lam C.W., Novel mutations in myopathic form of carnitine palmitoyltransferase II deficiency in a Chinese patient, In: Cho SY, Siu TS, Ma O, Tam S, Lam CW, Clin Chim Acta . 2013.

Kwok G., Kan A., Leung R.Y., Tam S., Lau W.C.S. and Kwong Y.L., Pyrexia, massive hepatomegaly, and extreme hyperferritinemia, Am J Med. 2014, 127(6): e13-4.

Li R.H.W., Lam K.S.L., Tam S., Lee V.C.Y., Yeung T.W.Y., Cheung P.T., Yeung W.S.B., Ho P.C. and Ng E.H.Y., Serum Level of Sex Hormone-Binding Globulin Is a Good Independent Predictor of Metabolic Syndrome in Women with Polycystic Ovary Syndrome, The 16th International Congress of Endocrinology & the Endocrine Society’s 96th Annual Meeting & Expo. 2014.

Yuen M., Tam S., Fong C., Chow W.S., Tan K.C.B. and Lam K.S.L., Cerebrotendinous Xanthomatosis in Seven Hong Kong Chinese., 16th International Congress of Endocrinology & the Endocrine Society's 96th Annual Meeting in Chicago, USA.. 2014.

Researcher : Tin PC

List of Research Outputs

Lee V.H.F., Tin P.C., Choy T.S., Lam K.O., Choi C.W., Chung L.P., Tsang J.W.H., Ho P.P., Leung D.K., Ma E.S., Liu J., Shek T.W.H., Kwong D.L.W., Leung T.W. and Wong M.P., Association of Exon 19 and 21 EGFR Mutation Patterns with Treatment Outcome after First-Line Tyrosine Kinase Inhibitor in Metastatic Non-Small-Cell Lung Cancer, In: Lee VH, Tin VP, Choy TS, Lam KO, Choi CW, Chung LP, Tsang JW, Ho PP, Leung DK, Ma ES, Liu J, Shek TW, Kwong DL, Leung TW, Wong MP, J Thorac Oncol. 2013, 8(9):1148-55.

Lee V.H.F., Tin P.C., Choy T.S., Lam K.O., Choi C.W., Chung L.P., Tsang J.W.H., Ho P.P.Y., Leung D.K.C. and Ma E.S.K., Association of Exon 19 and 21 EGFR Mutation Patterns with Treatment Outcome after First-Line Tyrosine Kinase Inhibitor in Metastatic Non–Small-Cell Lung Cancer, Journal of Thoracic Oncology. 2013, 8: 1148-1155.

Liu J., XIAO Z., Tin P.C., Wang J.J., Sham M.H. and Wong M.P., Lung cancer tumorigenicity and drug resistance are maintained through ALDHhiCD44hi tumor initiating cells, Oncotarget. 2013, 4(10): 1686-99.

Zhu H., Wong M.P. and Tin P.C., High-resolution detection of recurrent aberrations in lung adenocarcinomas by array comparative genomic hybridization and expression analysis of selective genes by quantitative PCR, In: H. Zhu, M. P. Wong and V. Tin, Int J Oncol . 2014.

de Figueiredo-Pontes L.L., Wong D.W.S., Tin P.C., Chung L.P., Yasuda H., Yamaguchi N., Nakayama S., Jänne P.A., Wong M.P., Kobayashi S.S. and Costa D.B., Identification and Characterization of ALK Kinase Splicing Isoforms in Non-Small-Cell Lung Cancer, In: de Figueiredo-Pontes LL, Wong DW, Tin VP, Chung LP, Yasuda H, Yamaguchi N, Nakayama S, Jänne PA, Wong MP, Kobayashi SS, Costa DB, Journal of Thoracic Oncology. 2014, 9(2): 248–253.

Researcher : Tsui WY

List of Research Outputs

Kuhmann C., LI C., Kloor M., Salou M., Weigel C., Schmidt C.R., Ng W.C.L., Tsui W.Y., Leung S.Y., Yuen S.T., Becker N., Weichenhan D., Plass C., Schmezer P., Chan T.L. and Popanda O., Altered regulation of DNA ligase IV activity by aberrant promoter DNA methylation and gene amplification in colorectal cancer., Hum Mol Genet. 2013, 23(8): 2043-54.

Wang K., Yuen S.T., Xu J., LEE S.P., Yan H.H.N., Shi S.T., Siu H.C., Deng S., Chu K.M., Law S.Y.K., CHAN K.H., Chan A.S.Y., Tsui W.Y., Ho R.S.L., Chan K.W., Man J.L.K., Foglizzo V., Ng M.K., Chan A.S., Ching Y.P., Cheng H.W.G., Xie T., Fernandez J., Li V.S.W., Clevers H., Rejto P.A., Mao M. and Leung S.Y., Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer, Nature Genetics. 2014, 46(6): 573-582.

Researcher : Wan TSK

List of Research Outputs

Lau C.S.T., Hansford L.M., Chan W.K., Chan G.C.F., Wan T.S.K., Wong K.K.Y., Kaplan D.R., Tam P.K.H. and Ngan E.S.W., Prokineticin signaling is required for the maintenance of a de novo population of c-KIT positive cells to sustain neuroblastoma progression, Oncogene. 2014.

NG H.Y., Wan T.S.K., So J.C.C. and Chim J.C.S., Epigenetic inactivation of DAPK1, p14ARF, mir-34a and -34b/c in acute promyelocytic leukemia, Journal of Clinical Pathology. 2014, 67(6): 626-631.

Wong K.Y., Wan T.S.K., So J.C.C. and Chim J.C.S., Establishment of a Chinese human multiple myeloma cell line: MMLAL, Cancer Cell Int. . 2013, 13(1): 122.

Researcher : Wong CCL

Project Title:	Cold Spring Harbor Asia Conference - Liver Metabolism, Diseases and Cancer Lysyl oxidase-like 2 is an important determinant of tumor and metastatic niche formation in hepatocellular carcinoma.
Investigator(s):	Wong CCL
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2012

Project Title:	The use of anti-lysyl oxidase-like 2 (anti-LOLX2) monocolonal antibodies in the treatment of liver cancer
Investigator(s):	Wong CCL
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	05/2013
Completion Date:	04/2014

Project Title:	The roles and regulations of pyruvate kinase 2 (PKM2) in hepatocellular carcinoma development
Investigator(s):	Wong CCL
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	09/2013

Project Title:	Role of lysyl oxidase-like 2 (LOXL2) in the progression and metastasis of liver cancer
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2013

Project Title:	Hepatitis B virus infection promotes hepatocellular carcinoma through HIF-lα/LOXL2 pathway
Investigator(s):	Wong CCL, Ng IOL, Sze MF
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	12/2013

Project Title:	The American Association for Cancer Research Annual Meeting 2014; Lysyl oxidase-like 2 promotes hepatocellular carcinoma metastasis by remodeling the tumor and metastatic microenvironments
Investigator(s):	Wong CCL
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2014

Project Title:	Clinical relevance and roles of hypoxia-induced NDUFA4L2 in hepatocellular carcinoma progression
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2014

List of Research Outputs

Au L.K.S., Wong C.C.L., Lee M.F., Wong C.M. and Ng I.O.L., EZH2-Mediated H3K27me3 Is Involved in Epigenetic Repression of Deleted in Liver Cancer 1 in Human Cancers, PLoS One. 2013, 8: e68226.

Wong C.C.L., Deregulation Of Lysyl Oxidase-like 2 Plays A Critical Role In Tumor Microenvironment And Metastatic Niche Formation To Promote Hepatocellular Carcinoma Metastasis, the Croucher Advanced Institute - Tumor Microenvironment- Cancer Cell Metabolism.. 2013.

Wong C.C.L. and Ng I.O.L., Lysyl oxidase-like 2 promotes hepatocellular carcinoma metastasis by remodeling the tumor and metastatic microenvironments, In: American Association for Cancer Research, American Association for Cancer Research (AACR) 105th Annual Meeting. 2014.

Wong C.C.L., Kai A.K.L. and Ng I.O.L., The Impact Of Hypoxia In Hepatocellular Carcinoma Metastasis, Frontiers Of Medicine. 2014.

Researcher : Wong CL

Project Title:	Cold Spring Harbor Asia Conference - Liver Metabolism, Diseases and Cancer Lysyl oxidase-like 2 is an important determinant of tumor and metastatic niche formation in hepatocellular carcinoma.
Investigator(s):	Wong CCL
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	05/2012

Project Title:	The use of anti-lysyl oxidase-like 2 (anti-LOLX2) monocolonal antibodies in the treatment of liver cancer
Investigator(s):	Wong CCL
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	05/2013
Completion Date:	04/2014

Project Title:	The roles and regulations of pyruvate kinase 2 (PKM2) in hepatocellular carcinoma development
Investigator(s):	Wong CCL
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	09/2013

Project Title:	Role of lysyl oxidase-like 2 (LOXL2) in the progression and metastasis of liver cancer
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	12/2013

Project Title:	Hepatitis B virus infection promotes hepatocellular carcinoma through HIF-lα/LOXL2 pathway
Investigator(s):	Wong CCL, Ng IOL, Sze MF
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	12/2013

Project Title:	The American Association for Cancer Research Annual Meeting 2014; Lysyl oxidase-like 2 promotes hepatocellular carcinoma metastasis by remodeling the tumor and metastatic microenvironments
Investigator(s):	Wong CCL
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2014

Project Title:	Clinical relevance and roles of hypoxia-induced NDUFA4L2 in hepatocellular carcinoma progression
Investigator(s):	Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2014

List of Research Outputs

Researcher : Wong CM

Project Title:	Polycomb silencing and microRNA deregulation in liver cancer
Investigator(s):	Wong CM
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	07/2011
Completion Date:	12/2013

Project Title:	Hypoxia and SETDB1 up-regulation in liver cancer
Investigator(s):	Wong CM, Wong CCL, Ng IOL
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	01/2012
Completion Date:	12/2013

Project Title:	Deregulation of SETDB1 and its functional roles in liver cancer
Investigator(s):	Wong CM
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2013

Project Title:	Deregulation of HOTTIP long non-coding RNA in liver cancer
Investigator(s):	Wong CM, Ng IOL
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2013

Project Title:	American Association for Cancer Reserach Annual Meeting; miR-200b/c/429 sub-family negatively regulating Rho/ROCK signaling pathway and suppresses HCC metastasis
Investigator(s):	Wong CM
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2014
Completion Date:	04/2014

Project Title:	Functional and pathological characterizations of chromatin remodeling protein HELLS in liver cancer
Investigator(s):	Wong CM, Ng IOL
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2014

List of Research Outputs

Au L.K.S., Wong C.C.L., Lee M.F., Wong C.M. and Ng I.O.L., EZH2-Mediated H3K27me3 Is Involved in Epigenetic Repression of Deleted in Liver Cancer 1 in Human Cancers, PLoS One. 2013, 8: e68226.

Jing Y., Jia D., Wong C.M., Ng I.O.L., Zhang Z., Liu L., Wang Q., Zhao F., Li J., Yao M., Wu X. and He X., SERPINA5 inhibits tumor cell migration by modulating the fibronectin-integrin β1 signaling pathway in hepatocellular carcinoma, Mol Oncol. 2014, 8: 366.

Li L., Mak K.Y., Shi J., Leung C.H., Wong C.M., Leung C.W., Mak S.K., Chan G.K.Y., Chan N.M.M., Wu E.X. and Pong P.W.T., Sterilization on Dextran-Coated Iron Oxide Nanoparticles: Effects of Filtration, Autoclaving, and Ethanol Treatment, Microelectronic Engineering,. 2013, 111: 310.

Mak K.Y., Li L., Wong C.M., Leung C.W., Shi J., Koon H.K., Mak S.K., Chan N.M.M. and Pong P.W.T., Quantitative Analysis of Hepatic Cell Morphology and Migration in Response to Nanoporous and Microgrooved Surface Structures, Microelectronic Engineering. 2013, 111: 396.

Wong C.M., Deregulation of SETDB1 and its pathological roles in hepatocellular carcinoma, State Key Laboratory for Liver Research (SKLLR) Symposium 2013. 2013.

Wong C.M., Deregulation of epigenetic regulator and their pathological implications in liver cancer, 20th Hong Kong International Cancer Congress. 2013.

Wong C.M., Editorial Board Member, Advances in Hepatology . 2013.

Wong C.M., Editorial Board Member, Austin Journal of Clinical Pathology . 2014.

Wong C.M., Editorial Board Member, Journal of Liver and Clinical Research . 2014.

Wong C.M., Editorial Board Member, World Journal of Gastroenterology . 2014.

Wong C.M., miR-200b/c/429 sub-family negatively regulating Rho/ROCK signaling pathway and suppresses HCC metastasis, State Key Laboratory of Oncogene and Related genes/State Key Laboratory for Liver Research/ Shanghai eastern hepatobiliary hospital joint symposium. 2013.

Researcher : Wong ESY

List of Research Outputs

Cheung A.M., Wong G.W., Chan K.K., Wong E.S.Y. and Cheung A.N.Y., FBI-1 and choriocarcinoma cell proliferation, Hong Kong International Cancer Congress 2013.

Siu K.Y., Wong E.S.Y., Kong S.H., Chan H.Y., JIANG L., Wong G.W., Chan K.K.L., Ngan H.Y.S., Le X.F. and Cheung A.N.Y., Stem Cell transcription factor NANOG controls cell migration and invasion via dysregulation of E-Cadherin and Fox JI and contributes to adverse clinical outcome in ovarian cancers. 2013, 32(30): 3500-9.

Zhao F., Siu K.Y., Wong G.W., Wong E.S.Y., Jiang L.L., Tam K.F., Ngan H.Y.S., Le X.F., Lam E.W.F. and Cheung A.N.Y., Role of FOXM1 in ovarian carcinogenesis, In: Zhao F, Siu MK, Wong OG, Wong ES, Jiang LL, Tam KF, Ngan HY, Le XF, Lam EWF, Cheung AN, AACR conference Advances in Ovarian Cancer Research: From Concept to Clinic. September 18-21, 2013. Miami, USA. Proceedings of the American Association for Cancer Research. 2013.

Researcher : Wong GW

Project Title:	Cellular functions and potential clinical application of miR-143 in cervical cancer
Investigator(s):	Wong GW, Cheung ANY, Ngan HYS
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	01/2014

List of Research Outputs

Cheung A.M., Wong G.W., Chan K.K., Wong E.S.Y. and Cheung A.N.Y., FBI-1 and choriocarcinoma cell proliferation, Hong Kong International Cancer Congress 2013.

Siu K.Y., Wong E.S.Y., Kong S.H., Chan H.Y., JIANG L., Wong G.W., Chan K.K.L., Ngan H.Y.S., Le X.F. and Cheung A.N.Y., Stem Cell transcription factor NANOG controls cell migration and invasion via dysregulation of E-Cadherin and Fox JI and contributes to adverse clinical outcome in ovarian cancers. 2013, 32(30): 3500-9.

Zhao F., Siu K.Y., Wong G.W., Wong E.S.Y., Jiang L.L., Tam K.F., Ngan H.Y.S., Le X.F., Lam E.W.F. and Cheung A.N.Y., Role of FOXM1 in ovarian carcinogenesis, In: Zhao F, Siu MK, Wong OG, Wong ES, Jiang LL, Tam KF, Ngan HY, Le XF, Lam EWF, Cheung AN, AACR conference Advances in Ovarian Cancer Research: From Concept to Clinic. September 18-21, 2013. Miami, USA. Proceedings of the American Association for Cancer Research. 2013.

Researcher : Wong KF

List of Research Outputs

WANG L., Kwong Y.L., Wong K.F., Kho C.S.B., Jin D., Tse E.W.C., Rosen A. and Chim J.C.S., Epigenetic inactivation of miR-34b/c in addition to miR-34a and DAPK1 in chronic lymphocytic leukemia, J Transl Med. 2014, 12(1): 52.

Wang L.Q., Kwong Y.L., Wong K.F., Kho C.S.B., Jin D., Tse E.W.C., Rosen A. and Chim J.C.S., Epigenetic inactivation of miR-34b/c in addition to miR-34a and DAPK1 in chronic lymphocytic leukemia, Journal of Translational Medicine. 2014, 12: 52-61.

Researcher : Wong M.P.

Project Title:	Mutational Analysis of Epidermal Growth Factor Receptor in Non-Small Cell Lung Cancer
Investigator(s):	Wong MP, Chua DTT
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2005

Project Title:	p38 MAPK in human lung cancers and its involvement in treatment resistance to tyrosine kinase inhibitors
Investigator(s):	Wong MP, Leung LH
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	02/2011

Project Title:	Investigation of tumor-propagating cells and stemness/differentiation axis pathways in non-small cell lung cancers
Investigator(s):	Wong MP, Sham MH, Wang JJ
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2011

Project Title:	The role of non-canonical Wnt signaling in cancer cell survival and drug resistance in lung cancer
Investigator(s):	Wong MP
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2013

Project Title:	The role of Ca2+/calmodulin-dependent protein kinase II (CaMKII) in tumour initiating cells (TIC) regulation in non-small cell lung cancer
Investigator(s):	Wong MP, Liu J
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	03/2014

Project Title:	4th International Conference on Tumor Progression and Therapeutic Resistance ; Inhibition of tumor initiating cells through Ca++/calmodulin-dependent protein kinase II (CaMKII) down-regulation enhances lung cancer therapy
Investigator(s):	Wong MP
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2014
Completion Date:	03/2014

Project Title:	Identification of cancer metastasis and drug resistance pathways through comparison of primary and metastatic lung adenocarcinomas by next generation sequencing analysis
Investigator(s):	Wong MP, Lee VHF, Sihoe DLA, Wang JJ, Sham PC
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2014

List of Research Outputs

Researcher : Wong MP

Project Title:	Mutational Analysis of Epidermal Growth Factor Receptor in Non-Small Cell Lung Cancer
Investigator(s):	Wong MP, Chua DTT
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	11/2005

Project Title:	p38 MAPK in human lung cancers and its involvement in treatment resistance to tyrosine kinase inhibitors
Investigator(s):	Wong MP, Leung LH
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	02/2011

Project Title:	Investigation of tumor-propagating cells and stemness/differentiation axis pathways in non-small cell lung cancers
Investigator(s):	Wong MP, Sham MH, Wang JJ
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	10/2011

Project Title:	The role of non-canonical Wnt signaling in cancer cell survival and drug resistance in lung cancer
Investigator(s):	Wong MP
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	06/2013

Project Title:	The role of Ca2+/calmodulin-dependent protein kinase II (CaMKII) in tumour initiating cells (TIC) regulation in non-small cell lung cancer
Investigator(s):	Wong MP, Liu J
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	03/2014

Project Title:	4th International Conference on Tumor Progression and Therapeutic Resistance ; Inhibition of tumor initiating cells through Ca++/calmodulin-dependent protein kinase II (CaMKII) down-regulation enhances lung cancer therapy
Investigator(s):	Wong MP
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	03/2014
Completion Date:	03/2014

Project Title:	Identification of cancer metastasis and drug resistance pathways through comparison of primary and metastatic lung adenocarcinomas by next generation sequencing analysis
Investigator(s):	Wong MP, Lee VHF, Sihoe DLA, Wang JJ, Sham PC
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	04/2014

List of Research Outputs

LI J., WANG Y., Xia Z., Wong M.P., Sham P.C. and Wang J.J., The best poster presentation award, The 5th International Conference on Computational and Systems Biology, SUSTC, Shenzhen, Nov15, 2013 . 2013.

LI J., WANG Y., Xia Z., Wong M.P., Sham P.C. and Wang J.J., dbPSHP: a database of recent positive selection across human populations, Nucleic Acids Res. 2013.

LI J., WANG Y., Xia Z., Wong M.P., Sham P.C. and Wang J.J., dbPSHP: a database of recent positive selection across human populations, Nucleic Acids Res. 2014, 42(Database issue): D910-6.

Lee V.H.F., Tin P.C., Choy T.S., Lam K.O., Choi C.W., Chung L.P., Tsang J.W.H., Ho P.P., Leung D.K., Ma E.S., Liu J., Shek T.W.H., Kwong D.L.W., Leung T.W. and Wong M.P., Association of Exon 19 and 21 EGFR Mutation Patterns with Treatment Outcome after First-Line Tyrosine Kinase Inhibitor in Metastatic Non-Small-Cell Lung Cancer, In: Lee VH, Tin VP, Choy TS, Lam KO, Choi CW, Chung LP, Tsang JW, Ho PP, Leung DK, Ma ES, Liu J, Shek TW, Kwong DL, Leung TW, Wong MP, J Thorac Oncol. 2013, 8(9):1148-55.

Liu J., XIAO Z., Tin P.C., Wang J.J., Sham M.H. and Wong M.P., Lung cancer tumorigenicity and drug resistance are maintained through ALDHhiCD44hi tumor initiating cells, Oncotarget. 2013, 4(10): 1686-99.

Ma L., Wang D.D., Huang Y., Wong M.P., Lee V.H.F. and Yan H., Decoding the EGFR mutation-induced drug resistance in lung cancer treatment by local surface geometric properties, In: Ma L, Wang DD, Huang Y, Wong MP, Lee VH and Yan H. , Comput Biol Med . 2014.

QIN J., LI J., WANG P., Wong N.S., Wong M.P., Xia Z., Tsao G.S.W., Zhang M.Q. and Wang J.J., ProteoMirExpress: inferring microRNA-centered regulatory networks from high throughput proteomic and mRNA expression data, Molecular & Cellular Proteomics. 2013, 12: 3379-3387.

Qin J., LI J., Wang P., Wong N.S., Wong M.P., Xia Z., Tsao G.S.W., Zhang M.Q. and Wang J.J., ProteoMirExpress: Inferring MicroRNA and Protein-centered Regulatory Networks from High-throughput Proteomic and mRNA Expression Data, Molecular & Cellular Proteomics. 2013, 12: 3379-3387.

WANG W., WANG P., XU F., LUO R., Wong M.P., Lam T.W. and Wang J.J., FaSD-somatic: A fast and accurate somatic SNV detection algorithm for cancer genome sequencing data, Bioinformatics. 2014.

Wang D.D., Zhou W., Yan H., Wong M.P. and Lee V.H.F., Personalized prediction of EGFR mutation-induced drug resistance in lung cancer, In: Debby D. Wang, Weiqiang Zhou, Hong Yan, Maria Wong & Victor Lee, Scientific Reports. 2013, 3:2855.

Wong M.P. and Lee V.H.F., 治療肺癌新契機, In: 王碧, 李浩勳, 育醫造才:探索醫學世界第三册, 2014, 71.

Zhu H., Wong M.P. and Tin P.C., High-resolution detection of recurrent aberrations in lung adenocarcinomas by array comparative genomic hybridization and expression analysis of selective genes by quantitative PCR, In: H. Zhu, M. P. Wong and V. Tin, Int J Oncol . 2014.

de Figueiredo-Pontes L.L., Wong D.W.S., Tin P.C., Chung L.P., Yasuda H., Yamaguchi N., Nakayama S., Jänne P.A., Wong M.P., Kobayashi S.S. and Costa D.B., Identification and Characterization of ALK Kinase Splicing Isoforms in Non-Small-Cell Lung Cancer, In: de Figueiredo-Pontes LL, Wong DW, Tin VP, Chung LP, Yasuda H, Yamaguchi N, Nakayama S, Jänne PA, Wong MP, Kobayashi SS, Costa DB, Journal of Thoracic Oncology. 2014, 9(2): 248–253.

Researcher : XIAO Z

List of Research Outputs

Liu J., XIAO Z., Tin P.C., Wang J.J., Sham M.H. and Wong M.P., Lung cancer tumorigenicity and drug resistance are maintained through ALDHhiCD44hi tumor initiating cells, Oncotarget. 2013, 4(10): 1686-99.

Researcher : Yam JWP

Project Title:	Outstanding Young Researcher Award 2008-2009
Investigator(s):	Yam JWP
Department:	Pathology
Source(s) of Funding:	Outstanding Young Researcher Award
Start Date:	12/2009

Project Title:	Interplay of caveolin-1 and met receptor in liver cancer metastasis
Investigator(s):	Yam JWP, Wong AST
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	01/2011

Project Title:	Functional significance of nuclear Met-driven nuclear factor kappa B pathway in liver cancer
Investigator(s):	Yam JWP, Wong AST
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2012
Completion Date:	06/2014

Project Title:	Study of COOH-terminal truncated HBx protein-activated oncogenic caveolin-1 in hepatocellular carcinoma
Investigator(s):	Yam JWP, Guan X
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2013

Project Title:	Clinical relevance and functions of nuclear Met in hepatocellular carcinoma metastasis
Investigator(s):	Yam JWP, Wong AST
Department:	Pathology
Source(s) of Funding:	General Research Fund (GRF)
Start Date:	11/2013

Project Title:	Role of caveolim-1 in hepatitis B virus-induced hepatocarcinogenesis
Investigator(s):	Yam JWP, Guan X
Department:	Pathology
Source(s) of Funding:	Health and Medical Research Fund - Full Grant
Start Date:	11/2013

Project Title:	American Association for Cancer Research Annual Meeting 2014; Role of nuclear Met in hepatocellular carcinoma
Investigator(s):	Yam JWP
Department:	Pathology
Source(s) of Funding:	URC/CRCG - Conference Support for Teaching Staff
Start Date:	04/2014
Completion Date:	04/2014

Project Title:	The functional role of phospho-DLC1S549-mediatd galectin-1 in liver cancer
Investigator(s):	Yam JWP, Ching YP
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Basic Research
Start Date:	06/2014

Project Title:	Development of combined therapeutic approach of Cav1 silencing with TACE for the treatment of liver malignancy
Investigator(s):	Yam JWP
Department:	Pathology
Source(s) of Funding:	Seed Funding Programme for Applied Research
Start Date:	06/2014

List of Research Outputs

Ko F.C.F., Yeung Y.S., Mao X. and Yam J.W.P., Novel RhoGAP independent pathway of tumor suppressor DLC1 regulates cancer invasion and metastasis, 2014 American Association for Cancer Research Annual Meeting. 2014.

Ko F.C.F. and Yam J.W.P., Regulation of Deleted in Liver Cancer 1 tumor suppressor by protein-protein interactions and phosphorylation, International Journal of Cancer. 2013, 135: 264-269.

LIU X., Siu K.Y., Liu S., Yam J.W.P., Ngan H.Y.S. and Chan D.W., Epigenetic silencing of microRNA-199b-5p is associated with acquired chemoresistance via activation of JAG1-Notch1 signaling in ovarian cancer., In: Andrei V. Gudkov and Mikhail V. Blagosklonny, Oncotarget. Impact Journals LLC, 2014, 5: 944–958.

Lam S.N., Mak A.S.C., Yam J.W.P., Cheung A.N.Y., Ngan H.Y.S. and Wong A.S.T., Targeting estrogen-related receptor alpha inhibits epithelial-to-mesenchymal transition and stem cell properties of ovarian cancer cells, In: Lam SS, Mak AS, Yam JW, Cheung AN, Ngan HY, Wong AS, Mol Ther. 2014.

TEY S.K. and Yam J.W.P., Role of nuclear Met in hepatocellular carcinoma, 2014 American Association for Cancer Research Annual Meeting. 2014.

Yam J.W.P., Advances in Hepatology . 2013.

Yam J.W.P., Journal of Liver: Disease & Transplantation . 2013.

Yam J.W.P., PLoS ONE, Public Libraray of Science. 2013.

Researcher : Yan HHN

Project Title:	Regulation of stromal miR125b on normal colonic epithelial cell renewal and tumorigenesis
Investigator(s):	Yan HHN, Leung SY
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	05/2014

List of Research Outputs

Wang K., Yuen S.T., Xu J., LEE S.P., Yan H.H.N., Shi S.T., Siu H.C., Deng S., Chu K.M., Law S.Y.K., CHAN K.H., Chan A.S.Y., Tsui W.Y., Ho R.S.L., Chan K.W., Man J.L.K., Foglizzo V., Ng M.K., Chan A.S., Ching Y.P., Cheng H.W.G., Xie T., Fernandez J., Li V.S.W., Clevers H., Rejto P.A., Mao M. and Leung S.Y., Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer, Nature Genetics. 2014, 46(6): 573-582.

Researcher : Yang N

Project Title:	The correlation between gene methylation and treatment sensitivity in breast cancer
Investigator(s):	Yang N, Khoo US
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	05/2013
Completion Date:	08/2013

Researcher : Yau TO

Project Title:	The role of Frizzled-7, receptor of the WNT/β-catenin signalling pathway, in hepatocellular carcinoma: Implications in tumorigenesis and metastasis
Investigator(s):	Yau TO, Ng IOL
Department:	Pathology
Source(s) of Funding:	Small Project Funding
Start Date:	10/2006

Researcher : Yeung MC

List of Research Outputs

Hui Y.L.E., Yeung M.C., Cheung P.T., Kwan E.Y.W., Tan K.C.B., Lam K.S.L. and Chan A.O.K., The clinical significance of aldosterone synthase deficiency: report of a novel mutation in the CYP11B2 gene., BMC Endocrine Disorder.. 2014, 14: 29.

Researcher : Yeung YS

List of Research Outputs

Ko F.C.F., Yeung Y.S., Mao X. and Yam J.W.P., Novel RhoGAP independent pathway of tumor suppressor DLC1 regulates cancer invasion and metastasis, 2014 American Association for Cancer Research Annual Meeting. 2014.

Researcher : Yuen LYP

List of Research Outputs

Lee H.H.C., Poon K.H., Lai C.K., Au K.M., Siu T.S., Lai J.P.S., Mak C.M., Yuen L.Y.P., Lam C.W. and Chan A.Y.W., Hyperornithinaemia-hyperammonaemia-homocitrullinuria syndrome: a treatable genetic liver disease warranting urgent diagnosis, In: Lee HH, Poon KH, Lai CK, Au KM, Siu TS, Lai JP, Mak CM, Yuen YP, Lam CW, Chan AY, Hong Kong Medical Journal. 2014, 20: 63-66.

Researcher : Yuen ST

List of Research Outputs

Kuhmann C., LI C., Kloor M., Salou M., Weigel C., Schmidt C.R., Ng W.C.L., Tsui W.Y., Leung S.Y., Yuen S.T., Becker N., Weichenhan D., Plass C., Schmezer P., Chan T.L. and Popanda O., Altered regulation of DNA ligase IV activity by aberrant promoter DNA methylation and gene amplification in colorectal cancer., Hum Mol Genet. 2013, 23(8): 2043-54.

Wang K., Yuen S.T., Xu J., LEE S.P., Yan H.H.N., Shi S.T., Siu H.C., Deng S., Chu K.M., Law S.Y.K., CHAN K.H., Chan A.S.Y., Tsui W.Y., Ho R.S.L., Chan K.W., Man J.L.K., Foglizzo V., Ng M.K., Chan A.S., Ching Y.P., Cheng H.W.G., Xie T., Fernandez J., Li V.S.W., Clevers H., Rejto P.A., Mao M. and Leung S.Y., Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer, Nature Genetics. 2014, 46(6): 573-582.

Researcher : Yung KY

List of Research Outputs

To K.K.W., Lam C.W., Lee K.C., Yung K.Y., Law C.Y., Leung K.F., Lau K.C. and Chan S.F., Difference In The Metabolome Between Escherichia Coli Isolated From Patients With Pyelonephritis And Cholangitis, Metabolomics Society 2013 Conference . 2013.

To K.K.W., Lam C.W., Wong S.S.Y., Law C.Y., Lee K.C., Yung K.Y., Cheung K.K. and Chan S.F., Urine Metabolomics Profile Of Patients With Or Without Bacteremia, International Symposium on Translating Omics Science to Clinical Applications 2013 (TOSCA'13). 2013.

Researcher : Zhao F

List of Research Outputs

Zhao F., Siu K.Y., Wong G.W., Wong E.S.Y., Jiang L.L., Tam K.F., Ngan H.Y.S., Le X.F., Lam E.W.F. and Cheung A.N.Y., Role of FOXM1 in ovarian carcinogenesis, In: Zhao F, Siu MK, Wong OG, Wong ES, Jiang LL, Tam KF, Ngan HY, Le XF, Lam EWF, Cheung AN, AACR conference Advances in Ovarian Cancer Research: From Concept to Clinic. September 18-21, 2013. Miami, USA. Proceedings of the American Association for Cancer Research. 2013.

-- End of Listing --