DEPT OF ANATOMY
| Researcher : CHEN Y |
| List of Research Outputs |
| CHEN Y., Hui Pun Hing Scholarships for Postgraduate Research at The University of Hong Kong for 2013-14, 2014. |
| Researcher : CHENG SY |
| List of Research Outputs |
| CHENG S.Y., Hung C.H.L. and Chang R.C.C., Interplay of the ubiquitin-proteasome system and the autophagy-lysosomal pathway in an in vitro model of Alzheimer’s disease., The 9th International Symposium of Healthy Aging. 2014, 60. |
| CHENG S.Y., Hung C.H.L. and Chang R.C.C., Interplay of the ubiquitin-proteasome system and the autophagy-lysosome pathway in cultured neurons stressed by oligomeric b-amyloid peptide, Neuroscience 2013. Program # 40.13: Poster # G33. |
| Chang R.C.C., Wuwongse S., Wong S., Wong M.T.H., TSANG A.W.-.T., Zhang E., CHENG S.Y., Hung C.H.L., Lau W.M., Ho Y.S., So K.F. and Law A.C.K., Investigating biological mechanisms of corticosterone-induced neurodegeneration: Implication of how depression promotes cognitive impairment in Alzheimer's disease, Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 2013, 9 Issue 4 Supplement: 561-562. |
| Chang R.C.C., Ho Y.S., WONG T.H.G., TSANG A.W.-.T., WUWONGSE S., POON C.H., YOU R., HUANG C., Ng T.W., CHENG S.Y., Hung C.H.L., LEUNG Y., Yang X., Law A.C.K., Chiu K., Lau W.M., Mak J.C.W., Wong G.T.C., Lee S.M.Y. and Hoi M.P.M., Investigating mechanisms of risk factors for Alzheimer’s disease to learn how to prevent disease progression., International Alzheimer’s Disease Conference 2014. 24. |
| Chang R.C.C., TSANG A.W.-.T., Wong G.T.H., CHENG S.Y., Hung C.H.L., Ho Y.S. and Law A.C.K., Targeting depression to prevent dementia and Alzheimer's disease, International Conference on Pharmacology and Drug Development, Singapore 2013.. 2013, : 65. |
| Hung C.H.L., CHENG S.Y., Lee S.M.Y. and Chang R.C.C., A reciprocal relationship between oxygen species and mitochondrial dynamics in neurodegeneration., The 9th International Symposium of Healthy Aging. 2014, 59. |
| WUWONGSE S., CHENG S.Y., WONG T.H.G., Hung C.H.L., ZHANG Q., HO Y.S., Law A.C.K. and Chang R.C.C., Effects of corticosterone and amyloid-beta on proteins essential for synaptic function: Implications for depression and Alzheimer's disease, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2013. |
| YOU R., Hung C.H.L., CHENG S.Y., Ho Y.S. and Chang R.C.C., Neuroprotective effects of honokiol in 6-hydroxydopamine-induced neurotoxicity., The 9th International Symposium of Healthy Aging. 2014, 61. |
| Researcher : Chan CWY |
| Project Title: | Linking autophagy and inflammation in human embryonic stem cell-derived cardiomyocytes |
| Investigator(s): | Chan CWY, Li RA |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2013 |
| Completion Date: | 04/2014 |
| Project Title: | Human embryonic stem cell-derived cardiomyocyte as a model to study the role of autophagy in cardiac inflammation |
| Investigator(s): | Chan CWY, Li RA |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 11/2013 |
| Project Title: | Costimulation blockade to promote survival of human embryonic stem cell-derived cardiomyocytes in a humanized mouse model. |
| Investigator(s): | Chan CWY |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2014 |
| List of Research Outputs |
| Wang J., Keung W.W.Y., Chan C.W.Y. and Li R.A., Effect of engineered anisotropy on the susceptibility of human pluripotent stem cell-derived ventricular cardiomyocytes to arrhythmias., Biomaterials. 2013. |
| Researcher : Chan OOC |
| List of Research Outputs |
| Chan L.K., Chan O.O.C., Kwan A.L.H., So K.F., Tipoe G.L., Tsao G.S.W. and Wong P.W.L., Faculty Knowledge Exchange Award, The University of Hong Kong. 2014. |
| Researcher : Chan TK |
| Project Title: | The impact of educational intervention on registration as an organ donor: a pilot study |
| Investigator(s): | Chan TK, Ho MCT |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 01/2013 |
| Completion Date: | 03/2014 |
| Project Title: | Centre for Biomedical Ethics’ Journal club series; The Policy Statement of the American Academy of Pediatrics – Children as Hematopoietic Stem Cell Donors – a proposal of amendments for better protection of minors |
| Investigator(s): | Chan TK |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2013 |
| Completion Date: | 09/2013 |
| List of Research Outputs |
| Chan T.K., Hui E. and Chung B.H.Y., A child born with Edward's syndrome: the legal and moral duty to accede to the request for parentage determination, Journal of Medical Ethics. 2014, 40: 383-386. |
| Chan T.K., Lee C.Y.Y., Yau S.K. and Tipoe G.L., Debate & Analysis Primary care in Asia: a call for compulsory vocational training, British Journal of General Practice. 2014, 64: 304-305. |
| Researcher : Chang R.C.C. |
| Project Title: | Significance of molecular signaling for protein translation control in neurodegeneration of amyotrophic lateral sclerosis |
| Investigator(s): | Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | Liu Po Shan/Dr Vincent Liu Endowment Fund for Motor Neuron diseases - General Award |
| Start Date: | 03/2008 |
| Project Title: | Elucidating the roles of PKR in the brain during systemic inflammation |
| Investigator(s): | Chang RCC, Ho YS, Chiu K, Cheung KH |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2013 |
| Completion Date: | 04/2014 |
| Project Title: | Society for Neuroscience Annual Meeting 2013; Examination of the retina in triple transgenic mice of Alzheimer’s disease |
| Investigator(s): | Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2013 |
| Completion Date: | 11/2013 |
| Project Title: | Investigating tau degradation: the underlying mechanisms for the pathogenesis of Alzheimer’s disease |
| Investigator(s): | Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2014 |
| List of Research Outputs |
| Researcher : Chang RCC |
| Project Title: | Significance of molecular signaling for protein translation control in neurodegeneration of amyotrophic lateral sclerosis |
| Investigator(s): | Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | Liu Po Shan/Dr Vincent Liu Endowment Fund for Motor Neuron diseases - General Award |
| Start Date: | 03/2008 |
| Project Title: | Elucidating the roles of PKR in the brain during systemic inflammation |
| Investigator(s): | Chang RCC, Ho YS, Chiu K, Cheung KH |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2013 |
| Completion Date: | 04/2014 |
| Project Title: | Society for Neuroscience Annual Meeting 2013; Examination of the retina in triple transgenic mice of Alzheimer’s disease |
| Investigator(s): | Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2013 |
| Completion Date: | 11/2013 |
| Project Title: | Investigating tau degradation: the underlying mechanisms for the pathogenesis of Alzheimer’s disease |
| Investigator(s): | Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2014 |
| List of Research Outputs |
| CHENG S.Y., Hung C.H.L. and Chang R.C.C., Interplay of the ubiquitin-proteasome system and the autophagy-lysosomal pathway in an in vitro model of Alzheimer’s disease., The 9th International Symposium of Healthy Aging. 2014, 60. |
| CHENG S.Y., Hung C.H.L. and Chang R.C.C., Interplay of the ubiquitin-proteasome system and the autophagy-lysosome pathway in cultured neurons stressed by oligomeric b-amyloid peptide, Neuroscience 2013. Program # 40.13: Poster # G33. |
| Chang R.C.C., Biological basis of risk factors in developing Alzheimer's disease, The 16th Asia Pacific Regional Conference of Alzheimer's Disease International: Capacity Building in Dementia Care. Hong Kong. 2013. |
| Chang R.C.C., Co-Chairman, International Alzheimer's Disease Conference 2014: Theme: "Early Detection, Treatment & Prevention of Dementia: Patients' and Caregivers' Perspectives", HKU Alzheimer's Disease Research Network. 2014. |
| Chang R.C.C., Editorial Board Member, Advances in Neuroscience Research. 2014. |
| Chang R.C.C., Editorial Board Member, Asian Journal of Neuroscience. 2014. |
| Chang R.C.C., Editorial Board member, Anatomy and Physiology: Current Research. 2014. |
| Chang R.C.C., Editorial Board member, Dataset Paper in Medicine (Ophthalmology). 2014. |
| Chang R.C.C., Editorial Board member, Journal of Brain and Behavioral Sciences. 2014. |
| Chang R.C.C., Editorial Board member, Journal of Neurology and Psychology. 2014. |
| Chang R.C.C., Ethic Committee for Animal Subjects, Hong Kong Polytechnic University. 2014. |
| Chang R.C.C., Chiu K., Lok C.K.M., Turner R.S., Matsuoka Y. and So K.F., Examination of the retina in triple transgenic mice of Alzheimer's disease, Neuroscience 2013. Program # 710.13: Poster # G7. |
| Chang R.C.C., Guest Editor, BioMed Research International. 2013. |
| Chang R.C.C., Wuwongse S., Wong S., Wong M.T.H., TSANG A.W.-.T., Zhang E., CHENG S.Y., Hung C.H.L., Lau W.M., Ho Y.S., So K.F. and Law A.C.K., Investigating biological mechanisms of corticosterone-induced neurodegeneration: Implication of how depression promotes cognitive impairment in Alzheimer's disease, Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 2013, 9 Issue 4 Supplement: 561-562. |
| Chang R.C.C., Ho Y.S., WONG T.H.G., TSANG A.W.-.T., WUWONGSE S., POON C.H., YOU R., HUANG C., Ng T.W., CHENG S.Y., Hung C.H.L., LEUNG Y., Yang X., Law A.C.K., Chiu K., Lau W.M., Mak J.C.W., Wong G.T.C., Lee S.M.Y. and Hoi M.P.M., Investigating mechanisms of risk factors for Alzheimer’s disease to learn how to prevent disease progression., International Alzheimer’s Disease Conference 2014. 24. |
| Chang R.C.C., Investigating mechanisms of risk factors for Alzheimer’s disease to learn how to prevent disease progression, International Alzheimer’s disease Conference, Hong Kong. 2014. |
| Chang R.C.C., Investigating the biological mechanisms of risk factors leading to dementia and Alzheimer's disease, Shenzhen-Hong Kong Alzheimer's Disease Conference, Shenzhen, CHINA . 2013. |
| Chang R.C.C., Molecular Mechanisms of Delaying Disease Progression to Preventing Disease Initiation in Alzheimer's Disease, Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. 2013. |
| Chang R.C.C., Molecular Mechanisms of Disease Progression to Risk Factors to Elucidate Potential Drug Targets for Alzheimer’s Disease, School of Chemical Biology & Biotechnology, Peking University Shenzhen Graduate School, Shenzhen, CHINA . 2014. |
| Chang R.C.C., Ho Y.S., WONG S., Gentleman S.M. and Ng H.K., Neuropathology of cigarette smoking, Acta Neuropathologica. Berlin Heidelberg, Springer, 2014, 127: 53-69. |
| Chang R.C.C., Neuroprotective Strategies to Delay and Prevent Alzheimer's Disease, State Key Laboratory of Quality Research in Chinese Medicine, Macau University of Science and Technology, Macau. 2014. |
| Chang R.C.C., Organizing Committee, The 9th International Symposium on Healthy Aging: Aging with Confidence. 2014. |
| Chang R.C.C., Targeting depression to prevent dementia and Alzheimer's Disease, International Conference on Pharmacology and Drug Development, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. 2013. |
| Chang R.C.C., TSANG A.W.-.T., Wong G.T.H., CHENG S.Y., Hung C.H.L., Ho Y.S. and Law A.C.K., Targeting depression to prevent dementia and Alzheimer's disease, International Conference on Pharmacology and Drug Development, Singapore 2013.. 2013, : 65. |
| Chang R.C.C., Wolfberry as an example of anti-aging Chinese medicine to prevent progressive neurodegeneration in Alzheimer's disease, The 2nd Integrative Medicine in Neurology, Beijing, CHINA. 2013. |
| Chiu K., Li J., Leung M.C., Chang R.C.C. and So K.F., Delayed trans-scleral electrical stimulation enhanced the survival of retinal ganglion cells after optic nerve axotomy, The 5th AEARU - Interdisciplinary medical and engineering symposium on the eye: tissue properties, pathology, treatments and devices. 2014. |
| Chiu K., Leung M.C., Leung I.Y.P., Lok C.K.M., Turner R., Matsuoka Y., So K.F. and Chang R.C.C., Morphometric analysis of the retina in a triple-transgenic model of Alzheimer's disease, Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 2013, 9, Issue 4, Supplement: 435. |
| Chiu K., Lok C.K.M., So K.F. and Chang R.C.C., Potential significance of chrysin as a neuroprotective agent to retinal ganglion cells in a rat model of glaucoma, The 6th Chinese Congress of Research in Vision and Ophthalmology. 2014. |
| HUANG C., Ho Y.S., Irwin M.G., Chang R.C.C. and Wong G.T.C., Comparing the effects of different anesthetics on tau protein phosphorylation., The 9th International Symposium of Healthy Aging. 2014, 59. |
| He M., Pan H., Chang R.C.C., So K.F., Brecha N.C. and Pu M., Activaton of the Nrf2/HO-1 antioxidant pathway contributes to the protective effects of lycium barbarum polysaccharides in the rodent retina after ischemia-reperfusion-induced damage, PLos One. 2014, 9 Issue 1: e84800. |
| Ho Y.S., Hung C.H.L., Lau C.F. and Chang R.C.C., Targeting the unfolded protein response in Alzheimer’s disease – a potential approach to reduce tau pathology., The 9th International Symposium of Healthy Aging. 2014, 61. |
| Hung C.H.L., CHENG S.Y., Lee S.M.Y. and Chang R.C.C., A reciprocal relationship between oxygen species and mitochondrial dynamics in neurodegeneration., The 9th International Symposium of Healthy Aging. 2014, 59. |
| LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Cheung K.H. and Fung M.L., Lycium barbarum polysaccharides facilitate hippocampal neurogenesis induced by chronic intermittent hypoxia in rats, 18th Research Postgraduate Symposium, HKU, P5.12, 12/2013. |
| LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Chan Y.S., Cheung K.H. and Fung M.L., Mechanisms of Lycium barbarum polysaccharides against spatial memory deficits in rats exposed to chronic intermittent hpoxia, Proc. International Symposium on Physiomics p.75. 2013. |
| LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Cheung K.H. and Fung M.L., Mechanistic effects of Lycium barbarum polysaccharides against rat hippocampal injuries induced by chronic intermittent hypoxia, The 17th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, CP3, 11/2013. (Journal of the Hong Kong College of Cardiology, 21(2):69, CP3, 2013). 2013. |
| LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Cheung K.H., Chan Y.S. and Fung M.L., Neuroprotective mechanisms of Lycium barbarum polysaccharides against spatial memory impairment induced by chronic intermittent hypoxia, The Ninth International Symposium on Healthy Aging – Aging with Confidence, OP7, 3/2014. |
| LEUNG Y., Chiu K. and Chang R.C.C., A comparison between medial forebrain bundle injection and striatal injection in 6-OHDA model of Parkinson’s disease., The 9th International Symposium of Healthy Aging. 2014, 59. |
| LEUNG Y., Chiu K. and Chang R.C.C., A comparison between medial forebrain bundle injection and striatal injection in 6-OHDA model of Parkinson’s disease, The 9th International Symposium of Healthy Aging. 2014. |
| Li H., Liang Y., Chiu K., Yuan Q., Lin B., Chang R.C.C. and So K.F., Lycium Barbarum (wolfberry) reduces secondary degeneration and oxidative stress, and inhibits JNK pathway in retina after partial optic nerve transection, PLoS. 2013, 8 issue 7 e68881: 1-13. |
| POON C.H., Ho Y.S., Lok C.K.M., Leung M.C., Chiu K. and Chang R.C.C., Differential modulation of bacteria-induced sickness and inflammation by double stranded RNA-dependent protein kinase (PKR), Neuroscience 2013. Program # 277.01: Poster # EEE22. |
| POON C.H., Ho Y.S., Lok C.K.M., Chiu K. and Chang R.C.C., Effects of double stranded RNA-dependent protein kinase (PKR) on bacteria-mediated sickness and inflammation., The 9th International Symposium of Healthy Aging. 2014, 66. |
| Sen A., Wang Y.Y., Chiu K., Whiley L., Cowan D., Chang R.C.C. and Legido-Quigley C., Metabolic phenotyping of the healthy rodent model using in-vial extraction of dried serum, urine and cerebrospinal fluid spots, Analytical Chemistry. 2013, 85: 7257. |
| Suen K., Li M., Chan W. and Chang R.C.C., A neuroscience pull-out gifted program in a high school in Hong Kong: Connection of neurodegenerative diseases and traditional Chinese medicine in research-based learning, Neuroscience 2013. Presentation/Poster # 24.10SU/MMM43. |
| Suen K., Chung H., Ma H., Ho P., Chow P., Tong J.T., Abbass G., Chung C. and Chang R.C.C., Dendrobium huoshanense can reduce hydrogen peroxide-induced toxicity in SH-SY5Y cells, Neuroscience 2013. Program # 343.18: Poster # DD14. |
| WONG T.H.G., Hung C.H.L., TSANG A.W.-.T., Chang R.C.C. and Law A.C.K., Microtubule dysfunction in corticosterone and oligomeric beta-amyloid in vitro model and its effect on actin morphology., The 9th International Symposium of Healthy Aging. 2014, 50. |
| WUWONGSE S., CHENG S.Y., WONG T.H.G., Hung C.H.L., ZHANG Q., HO Y.S., Law A.C.K. and Chang R.C.C., Effects of corticosterone and amyloid-beta on proteins essential for synaptic function: Implications for depression and Alzheimer's disease, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2013. |
| Wong G.T.H., Hung C.H.L., Law A.C.K. and Chang R.C.C., Oligomeric beta-amyloid and corticosterone trigger similar morphologic and dynamic changes in microtubules of cultured hippocampal neurons, Neuroscience 2013. Program # 40.11: Poster # G31. |
| Xiao J., Liong E.C., Chang R.C.C., Fung M.L., Xu A.M., So K.F. and Tipoe G.L., Lycium barbarum polysaccharides protect rat liver from non-alcoholic steatohepatitis-induced injury, Nutrition and Diabetes, Doi:10.1038/nutd.2013.22. 2013, 3,e81. |
| Xu M., Chen X., Gu Y., Peng T., Yang D., Chang R.C.C., So K.F., Liu K. and Shen J., Baicalin can scavenge peroxynitrite and ameliorate endogenous peroxynitrite-mediated neurotoxicity in cerebral ischemia-reperfusion injury, J Ethnopharmacol. 2013, 150(1): 116-24. |
| YOU R., Hung C.H.L., CHENG S.Y., Ho Y.S. and Chang R.C.C., Neuroprotective effects of honokiol in 6-hydroxydopamine-induced neurotoxicity., The 9th International Symposium of Healthy Aging. 2014, 61. |
| Researcher : Chau RMW |
| Project Title: | HUGO's Seventh International Human Genome Meeting, HGM2002 The Possible Mechanism of Action for Quinacrine Interacting the Scrapie Protein in Prion Disease |
| Investigator(s): | Chau RMW |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2002 |
| Researcher : Chen AYS |
| Project Title: | Study of the role of polyol pathway activation the impaired nerve regeneration in diabetes |
| Investigator(s): | Chen AYS, Chung SK |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 12/2008 |
| Researcher : Cheung A |
| Project Title: | Role of Id1-induced IGF2 in autocrine/endocrine promotion of esophageal cancer tumorigenesis and metastasis implications for targeted therapy |
| Investigator(s): | Cheung A, Chan KW, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2010 |
| Completion Date: | 09/2013 |
| Project Title: | Id1-induced IGF2 promotes esophageal cancer progression through instigation of stromal fibroblasts and bone marrow-derived vascular progenitor cells |
| Investigator(s): | Cheung A, Chan KW, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2012 |
| Project Title: | An integrated approach to identify genes associated with esophageal cancer progression |
| Investigator(s): | Cheung A, Li B |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2012 |
| Completion Date: | 05/2014 |
| Project Title: | MicroRNA-377 inhibits growth and metastasis of esophageal cancer stem-like cells by directly repressing CD133 – mechanisms and implications for cancer stem cell-targeted therapy |
| Investigator(s): | Cheung A, Chan KW, Law SYK, Tsao GSW, Li B |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 01/2013 |
| Project Title: | 17th ECCO - 38th ESMO - 32nd ESTRO European Cancer Congress; Id1-induced IGF2 promotes bidirectional interaction between esophageal cancer cells and fibroblasts in the tumor microenviro |
| Investigator(s): | Cheung A |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2013 |
| Completion Date: | 10/2013 |
| Project Title: | FBXO31 regulates stress-induced cell apoptosis by mediating K48-linked ubiquitination and degradation of phosphorylated MKK6 |
| Investigator(s): | Cheung A |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 04/2014 |
| List of Research Outputs |
| Cheung A., Editorial Board, The Open Pathology Journal. Bentham Open, 2014. |
| Cheung A., Identification and functional validation of cytokines that mediate the effects of Id1 on local invasion and distant metastasis (US$3,000), RayBiotech's 2013 Innovative Research Grant Program. 2013. |
| Cheung A., Xu W., Li B., Tsao G.S.W. and Chan K.W., Id1 induced IGF2 promotes bidirectional interaction between oesophageal cancer cells and fibroblasts in the tumour microenvironment, European Cancer Congress, Amsterdam, 27 September - 1 October 2013, Holland. 2013, 392. |
| Cheung A., Role of Id1 in esophageal cancer. (Shantou University Medical College, China), 2014. |
| HAN L., Li B., Tsao G.S.W. and Cheung A., Roles of miR-338-5p in downregulating Id-1 and inhibiting chemoresistance and cancer cell invasion, 20th Hong Kong International Cancer congress, November 14-15, 2013, Hong Kong. 2013, No. A21. |
| LIU J., Li B., Yang J., Huen M.S.Y., Tsao G.S.W. and Cheung A., FBX031 negatively regulates p38 MAPK by promoting ubiquitination and degradation of MAP kinase kinase 6, 20th Hong Kong International Cancer Congress, November 14-15, 2013, Hong Kong. 2013, No. A16. |
| Li B., Tsao G.S.W., Chan K.W., Ludwig D.L., Novosyadlyy R., Li Y.Y., He Q.Y. and Cheung A., Id1-induced IGF-II and its autocrine/endocrine promotion of esophageal cancer progression and chemoresistance-implications for IGF-II and IGF-IR-targeted therapy, Clinical Cancer Research. 2014, 2651-2662. |
| Li B., Tsao G.S.W., Chan K.W. and Cheung A., Id1/IGF2/IGF1R/P13K/AKT signaling cascade as functional markers and therapeutic targets in esophageal cancer, European Journal of Cancer. 2013, 49 Suppl. 4: S23 MC13-0039. |
| Liu J., HAN L., Li B., Yang J., Huen M.S.Y., Pan X., Tsao G.S.W. and Cheung A., F-box only protein 31 (FBX031) negatively regulates p38 mitogen-activated protein kinase (MAPK) signaling by mediating lysine 48-linked ubiquitination and degradation of mitogen-activated protein kinase kinase 6 (MKK6), Journal of Biological Chemistrry. 2014, 289: 21508-21518. |
| XU W., Li B., Tsao G.S.W., Chan K.W. and Cheung A., Mechanistic study of the interactions between Id1-overexpressing esophageal cancer cells and fibroblasts in the tumor microenvironment, 2013 NCRI Cancer Conference, 3-6 November 2013, Liverpool, U. K.. 2013, A191. |
| XU W., Li B., Tsao G.S.W., Chan K.W. and Cheung A., Suppression of angiogenesis and esophageal cancer progression by selective targeting of hematopoietic and endothelial progenitor cells, 18th International Vascular Biology Meeting, April 14-17, 2014, Kyoto, Japan. 2014, P-513. |
| Researcher : Cheung A. |
| Project Title: | Role of Id1-induced IGF2 in autocrine/endocrine promotion of esophageal cancer tumorigenesis and metastasis implications for targeted therapy |
| Investigator(s): | Cheung A, Chan KW, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2010 |
| Completion Date: | 09/2013 |
| Project Title: | Id1-induced IGF2 promotes esophageal cancer progression through instigation of stromal fibroblasts and bone marrow-derived vascular progenitor cells |
| Investigator(s): | Cheung A, Chan KW, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2012 |
| Project Title: | An integrated approach to identify genes associated with esophageal cancer progression |
| Investigator(s): | Cheung A, Li B |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2012 |
| Completion Date: | 05/2014 |
| Project Title: | MicroRNA-377 inhibits growth and metastasis of esophageal cancer stem-like cells by directly repressing CD133 – mechanisms and implications for cancer stem cell-targeted therapy |
| Investigator(s): | Cheung A, Chan KW, Law SYK, Tsao GSW, Li B |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 01/2013 |
| Project Title: | 17th ECCO - 38th ESMO - 32nd ESTRO European Cancer Congress; Id1-induced IGF2 promotes bidirectional interaction between esophageal cancer cells and fibroblasts in the tumor microenviro |
| Investigator(s): | Cheung A |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2013 |
| Completion Date: | 10/2013 |
| Project Title: | FBXO31 regulates stress-induced cell apoptosis by mediating K48-linked ubiquitination and degradation of phosphorylated MKK6 |
| Investigator(s): | Cheung A |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 04/2014 |
| List of Research Outputs |
| Researcher : Cheung ALM |
| Project Title: | Role of Id1-induced IGF2 in autocrine/endocrine promotion of esophageal cancer tumorigenesis and metastasis implications for targeted therapy |
| Investigator(s): | Cheung A, Chan KW, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2010 |
| Completion Date: | 09/2013 |
| Project Title: | Id1-induced IGF2 promotes esophageal cancer progression through instigation of stromal fibroblasts and bone marrow-derived vascular progenitor cells |
| Investigator(s): | Cheung A, Chan KW, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2012 |
| Project Title: | An integrated approach to identify genes associated with esophageal cancer progression |
| Investigator(s): | Cheung A, Li B |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2012 |
| Completion Date: | 05/2014 |
| Project Title: | MicroRNA-377 inhibits growth and metastasis of esophageal cancer stem-like cells by directly repressing CD133 – mechanisms and implications for cancer stem cell-targeted therapy |
| Investigator(s): | Cheung A, Chan KW, Law SYK, Tsao GSW, Li B |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 01/2013 |
| Project Title: | 17th ECCO - 38th ESMO - 32nd ESTRO European Cancer Congress; Id1-induced IGF2 promotes bidirectional interaction between esophageal cancer cells and fibroblasts in the tumor microenviro |
| Investigator(s): | Cheung A |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2013 |
| Completion Date: | 10/2013 |
| Project Title: | FBXO31 regulates stress-induced cell apoptosis by mediating K48-linked ubiquitination and degradation of phosphorylated MKK6 |
| Investigator(s): | Cheung A |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 04/2014 |
| List of Research Outputs |
| Researcher : Cheung MCH |
| Project Title: | In vivo Functional Analysis of Posttranslational Modifications of Sox9 in Neural Crest Development |
| Investigator(s): | Cheung MCH, Zhou G |
| Department: | Biochemistry |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2010 |
| Project Title: | In vivo identification and characterization of cis-regulatory elements and upstream effectors to control Sox9 expression at the onset of neural crest specification |
| Investigator(s): | Cheung MCH |
| Department: | Biochemistry |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2012 |
| Completion Date: | 09/2013 |
| Project Title: | Avian Model Systems; BMP and canonical Wnt signaling regulate neural crest delamination by controlling Sox9 phosphorylation and its interaction with Snail2 |
| Investigator(s): | Cheung MCH |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 03/2014 |
| Completion Date: | 03/2014 |
| Project Title: | Investigating the roles of SOX9 in human neural stem cells |
| Investigator(s): | Cheung MCH |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| List of Research Outputs |
| Cheung M.C.H., Dissecting The Downstream Molecular Events Of Sox9 In Regulating The Transition From Neural Crest Delamination To Migration, The Microscopy Society Singapore. 2014. |
| Cheung M.C.H., Post-Translational Regulation of Sox9 Function in Avian Neural Crest Development, Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore. 2014. |
| Kam K.M., Cheung M.C.H., Zhu J.J., Cheng W.W., Sat E.W.Y., Tam P.K.H. and Lui V.C.H., Perturbation of Hoxb5 signaling in vagal and trunk neural crest cells causes apoptosis and neurocristopathies in mice, Cell Death & Differentiation. 2013, 21(2): 278-289. |
| Researcher : Cheung MPL |
| List of Research Outputs |
| DAI Y., PAN Y., Cheung M.P.L. and Yip H.K.F., Inhibition Of Stat/smad Co-transcription Factor P300 Regulates Differentiation Of Adult Spinal Cord Neural Progenitors And Ameliorates Functional Recovery In Chronic Spinal Cord, Ninth International Symposium On Healthy Aging. 2014. |
| Liao S., Cheung K.H., Cheung M.P.L., To J.Y.T., O W.S. and Tang F., Adrenomedullin increased the short-circuit current in the pig oviduct through chloride channels via the CGRP receptor: Mediation by cAMP and calcium ions but not by nitric oxide, Biology of Reproduction. 2013, 89(4): 99, 1-6. |
| Liao S., Cheung K.H., Cheung M.P.L., Wong P.F., O W.S. and Tang F., Adrenomedullin increases the short-circuit current in the rat prostate: Receptors, chloride channels, the effects of cAMP and calcium ions and implications on fluid secretion, Andrology. 2014, 2: 474-480. |
| PAN Y., DAI Y., Cheung M.P.L. and Yip H.K.F., The Role Of GSK3-beta Pathway In Oligodendroglial Progenitor Cell Differentiation And Remyelination After Spinal Cord Injury, Ninth International Symposium On Healthy Aging. 2014. |
| Researcher : Cheung YC |
| List of Research Outputs |
| Tsang C.M., Cheung Y.C., Lui W.Y.V., Yip Y.L., Zhang G., LIN W., Cheung K.C.P., Feng Y. and Tsao G.S.W., Berberine suppresses tumorigenicity and growth of nasopharyngeal carcinoma cells by inhibiting STAT3 activation induced by tumor associated fibroblasts, BMC Cancer. 2013, 13: 619. |
| Researcher : Ching Y.P. |
| Project Title: | Roles of p21-activated protein kinase (Pak) 1 in the pathogenesis of liver cancer |
| Investigator(s): | Ching YP, Ng IOL, Jin D, Yau TO |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2006 |
| Project Title: | Hepatitis B virus promotes hepatocarcinogenesis by activation of Pak1 |
| Investigator(s): | Ching YP, Jin D |
| Department: | Anatomy |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 01/2010 |
| Completion Date: | 08/2014 |
| Project Title: | Regulation of p53 by PAK4 in hepatocellular carcinoma |
| Investigator(s): | Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2012 |
| Completion Date: | 04/2014 |
| Project Title: | HBx oncoprotein induces chromosome instability in hepatocarcinogenesis via dysregulation of centrosome duplication regulatory protein, TAX1BP2 |
| Investigator(s): | Ching YP, Jin D |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2013 |
| Project Title: | The role of centrosomal kinase Nek2 in the pathogenesis of liver cancer |
| Investigator(s): | Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2013 |
| Project Title: | Functional characterization of the roles of NIMA-related kinase, Nek2 in liver cancer development and metastasis |
| Investigator(s): | Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| List of Research Outputs |
| Researcher : Ching YP |
| Project Title: | Roles of p21-activated protein kinase (Pak) 1 in the pathogenesis of liver cancer |
| Investigator(s): | Ching YP, Ng IOL, Jin D, Yau TO |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2006 |
| Project Title: | Hepatitis B virus promotes hepatocarcinogenesis by activation of Pak1 |
| Investigator(s): | Ching YP, Jin D |
| Department: | Anatomy |
| Source(s) of Funding: | Research Fund for the Control of Infectious Diseases - Full Grants |
| Start Date: | 01/2010 |
| Completion Date: | 08/2014 |
| Project Title: | Regulation of p53 by PAK4 in hepatocellular carcinoma |
| Investigator(s): | Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2012 |
| Completion Date: | 04/2014 |
| Project Title: | HBx oncoprotein induces chromosome instability in hepatocarcinogenesis via dysregulation of centrosome duplication regulatory protein, TAX1BP2 |
| Investigator(s): | Ching YP, Jin D |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 03/2013 |
| Project Title: | The role of centrosomal kinase Nek2 in the pathogenesis of liver cancer |
| Investigator(s): | Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2013 |
| Project Title: | Functional characterization of the roles of NIMA-related kinase, Nek2 in liver cancer development and metastasis |
| Investigator(s): | Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| List of Research Outputs |
| Chan C.P., Siu Y.T., Kok K.H., Ching Y.P., Tang V.H.M. and Jin D., Group I p21-activated kinases facilitate Tax-mediated transcriptional activation of the human T-cell leukemia virus type 1 long terminal repeats, Retrovirology. 2013, 10: 47. |
| Ching Y.P., A specific role of AMP-activated Protein Kinase in Hepatocarcinogenesis, In: Hong Kong International Cancer Congress, 19th Hong Kong International Cancer Congress. Hong Kong, 2013. |
| KWAN K.K. and Ching Y.P., Role of PAK4 in Extracellular matrix (ECM) Degradation, In: European Molecular Biology Laboratory, EMBO|EMBL Symposium: Tumour microenvironment and signalling 2014. Heidelberg. |
| Tse E.Y.T. and Ching Y.P., Functional characterization of NIMA (never in mitosis gene a)-related kinase 2 in Hepatocellular Carcinoma, The 17th ECCO-38th ESMO-32nd ESTRO European Cancer Congress. 2013. |
| Wang K., Yuen S.T., Xu J., LEE S.P., Yan H.H.N., Shi S.T., Siu H.C., Deng S., Chu K.M., Law S.Y.K., CHAN K.H., Chan A.S.Y., Tsui W.Y., Ho R.S.L., Chan K.W., Man J.L.K., Foglizzo V., Ng M.K., Chan A.S., Ching Y.P., Cheng H.W.G., Xie T., Fernandez J., Li V.S.W., Clevers H., Rejto P.A., Mao M. and Leung S.Y., Whole-genome sequencing and comprehensive molecular profiling identify new driver mutations in gastric cancer, Nature Genetics. 2014, 46(6): 573-582. |
| Wong L.L.Y., Lam P.Y., WONG Y.N., Lai W.L., Liu M.H.F., Yeung L.L. and Ching Y.P., IPA-3 inhibits the growth of liver cancer cells by suppressing PAK1 and NF-kB activation, PLOS ONE. 2013, 8(7), pp: e68843. |
| Researcher : Chiu K |
| List of Research Outputs |
| Chang R.C.C., Chiu K., Lok C.K.M., Turner R.S., Matsuoka Y. and So K.F., Examination of the retina in triple transgenic mice of Alzheimer's disease, Neuroscience 2013. Program # 710.13: Poster # G7. |
| Chiu K., Leung M.C., Leung I.Y.P., Lok C.K.M., Turner R., Matsuoka Y., So K.F. and Chang R.C.C., Morphometric analysis of the retina in a triple-transgenic model of Alzheimer's disease, Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 2013, 9, Issue 4, Supplement: 435. |
| Li H., Liang Y., Chiu K., Yuan Q., Lin B., Chang R.C.C. and So K.F., Lycium Barbarum (wolfberry) reduces secondary degeneration and oxidative stress, and inhibits JNK pathway in retina after partial optic nerve transection, PLoS. 2013, 8 issue 7 e68881: 1-13. |
| POON C.H., Ho Y.S., Lok C.K.M., Leung M.C., Chiu K. and Chang R.C.C., Differential modulation of bacteria-induced sickness and inflammation by double stranded RNA-dependent protein kinase (PKR), Neuroscience 2013. Program # 277.01: Poster # EEE22. |
| POON C.H., Ho Y.S., Lok C.K.M., Chiu K. and Chang R.C.C., Effects of double stranded RNA-dependent protein kinase (PKR) on bacteria-mediated sickness and inflammation., The 9th International Symposium of Healthy Aging. 2014, 66. |
| Sen A., Wang Y.Y., Chiu K., Whiley L., Cowan D., Chang R.C.C. and Legido-Quigley C., Metabolic phenotyping of the healthy rodent model using in-vial extraction of dried serum, urine and cerebrospinal fluid spots, Analytical Chemistry. 2013, 85: 7257. |
| Yuan Q., Su H., Chiu K., Wu W. and Lin Z.X., Assessment of the rate of spinal motor axonal regeneration by ChAT immunohistochemistry, Journal of Neurosurgery. 2013. |
| Researcher : Chung SK |
| Project Title: | Molecular Basis for Diabetes-induced Painless and Painful Neuropathy, and Inability to Structurally and Functionally Recovery after Peripheral Nerve Injury |
| Investigator(s): | Chung SK |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2012 |
| Project Title: | Stem Cell Strategy for Nervous System Disorders |
| Investigator(s): | Chung SK |
| Department: | Anatomy |
| Source(s) of Funding: | Theme-based Research Scheme |
| Start Date: | 09/2012 |
| Project Title: | The pathogenesis of dopaminergic neuronal loss in Parkinson’s disease and therapeutic restoration of dopaminergic neurons |
| Investigator(s): | Chung SK |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2013 |
| Completion Date: | 04/2014 |
| Project Title: | To Determine the Role of Exchange Protein Directly Activated by cAMP, Epac 1 and Epac2, in the Blood-retinal Barrier and Neuroinflammation in Retina |
| Investigator(s): | Chung SK |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| List of Research Outputs |
| BARETELLA O.M., Chung S.K., Barton M., Xu A. and Vanhoutte P.M.G.R., Obesity and heterozygous endothelial overexpression of prepro-endothelin-1 modulate responsiveness of mouse main and segmental renal arteries to vasoconstrictor agents., Life Sci. . 2014, Epub ahead of print. |
| Baretella O.M., Chung S.K., Xu A. and Vanhoutte P.M.G.R., Heterozygous Endothelial Endothelin-1 Overexpression Potentiates Endothelium-Dependent Contractions in the Carotid Arteries of Obese Mice, HBPR 2013, September 11-14, 2013, New Orleans, LA. 2013. |
| Baretella O.M., Chung S.K., Xu A. and Vanhoutte P.M.G.R., Heterozygous overexpression of preproendothelin-1 in endothelial cells enhances thromboxane-prostanoid receptor-induced contractions in the renal artery of obese mice, 13th International Conference on Endothelin, September 8-11, 2013, University of Tsukuba, Tokyo. 2013. |
| Baretella O.M., Chung S.K., Xu A. and Vanhoutte P.M.G.R., Improved relaxations to acetylcholine in murine carotid arteries with heterozygous overexpression of preproendothelin-1 in the endothelium, 13th International Conference on Endothelin, September 8-11, 2013, University of Tsukuba, Tokyo. 2013. |
| Cheng O.Y., Lam K.S.L., Chung S.K., Xu A., Yeung P.K.K., Kwan S.C., Ho W.L., Cheng K.Y., Guo Y. and Chan K.H., Cognitive impairment in adiponectin-knockout mice, 19th Medical Research Conference, Department of Medicine, The University of Hong Kong,. Hong Kong, Hong Kong Medicine Journal, 2014, 20 Number 1 (Suppl 1): 14. |
| Durairajan S.S.K., Yuen Y., Chen L.L., Kwok K.Y., Liu L.F., Song J.X., Han Q.B., Xue L., Chung S.K., Huang J. and Li M., Effects of Huanglian-Jie-Du-Tang and its modified formula on the modulation of amyloid-β precursor protein processing in Alzheimer's disease models. , PLoS ONE . 2014, 9(3): e92954. |
| Guo Y., Chung S.K., Siu D.C.W., Kwan S.C., Ho W.L., Yeung P.K.K., Teo K.C. and Chan K.H., Endothelin-1 overexpression exacerbate experimental allergic encephalomyelitis, Physiology Symposium 2014 & Joint Scientific Conference of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong. 2014. |
| Hung K.L., TAI W.L., LUO X., Sun L.T., QIU Q., Chung S.K. and Cheung C.W., Endothelin-1 over-expression in astrocyte attenuates peripheral neuropathic pain by up-regulating the expression of excitatory amino acid transporter-2 in lumbar spinal cord., 7th World Congress. World Institute of Pain, masstricht, Netherland. 7-10 May 2014. |
| Hung K.L., Tai W.L., Qiu Q., Luo X., Wong K., Chung S.K. and Cheung C.W., Over-expression of astrocytic ET-1 attenuates neuropathic pain by inhibition of ERK1/2 and Akt(s) via activation of ETA receptor, Molecular and Cellular Neuroscience. 2014, 60: 26-35. |
| Jo W.K., Law A.C.K. and Chung S.K., The neglected co-star in the dementia drama: the putative roles of astrocytes in the pathogeneses of major neurocognitive disorders, Molecular Psychiatry. 2014, 19 (2): 159-167. |
| LUO X., TAI W.L., Sun L.T., QIU Q., Xia Z., Chung S.K. and Cheung C.W., Central administration of C-X-C chemokine receptor type 4 antagonist alleviates the development and maintenance of peripheral neuropathic pain in mice, The FASEB Journal: Experimental Biology 2014. 28(1): Supplement LB618. |
| LUO X., TAI W.L., Sun L.T., Xia Z., Chung S.K. and Cheung C.W., Central administration of CXCR4 antagonist prevents the development of peripheral neuropathic pain and modulates the spinal expression of neuropeptides and pro-inflammatory cytokines in mice., Euroanaesthesia 2014. 31 May - 3 June 2014. |
| LUO X., TAI W.L., Sun L.T., QIU Q., Xia Z., Chung S.K. and Cheung C.W., Endothelial cell-targeted over-expressing Et-1 leads to increased blood pressure and decreased heart rate in aged mice., Experimental Biology, USA. 26-30 May 2014. |
| Li C., Ng K.T.P., Shao Y., Liu X., Ling C., Ma Y.Y., Geng W., Qi X., Cheng Q., Chung S.K., Lo C.M. and Man K., The inhibition of aldose reductase attenuates hepatic ischemia-reperfusion injury through reducing inflammatory response, Annals of Surgery. 2014, Epub on 2014-01-20. |
| Lo A.C.Y., Fu Z. and Chung S.K., Aldose reductase deficiency protects retinal neurons against oxygen-induced retinopathy, Neuroscience 2013. |
| Nian S., Fu Z., Chung S.K. and Lo A.C.Y., Aldose reductase deficiency protects neuroretinal morphology and function in mouse model of oxygen induced retinopathy, Ninth International Symposium on Healthy Aging: “Aging with Confidence”. 2014. |
| ZHANG L., Chung S.K. and Chow B.K.C., The Knockout of Secretin in Cerebellar Purkinje Cells Impairs Mouse Motor Coordination and Motor Learning, Neuropsychopharmacology. 2014, 39: 1460. |
| Researcher : DAI Y |
| List of Research Outputs |
| DAI Y., PAN Y. and Yip H.K.F., Combined Lithium And Noggin Treatment Regulates The Differentiation Of Neural Progenitor Cells In The Adult Spinal Cord And Promotes Functional Recovery After Chronic Spinal Cord Injury, 18th Research Postgraduate Sympsoium. 2013. |
| DAI Y., PAN Y., Cheung M.P.L. and Yip H.K.F., Inhibition Of Stat/smad Co-transcription Factor P300 Regulates Differentiation Of Adult Spinal Cord Neural Progenitors And Ameliorates Functional Recovery In Chronic Spinal Cord, Ninth International Symposium On Healthy Aging. 2014. |
| PAN Y., DAI Y. and Yip H.K.F., The Role Of GSK3-Beta Pathway In Oligodendroglial Progenitor Cell (OPC) Differentiation And Remyelination After Spinal Cord Injury (SCI), 18th Research Postgraduate Symposium, Li Ka Shing Faculty Of Medicine, HKU. 2013. |
| PAN Y., DAI Y., Cheung M.P.L. and Yip H.K.F., The Role Of GSK3-beta Pathway In Oligodendroglial Progenitor Cell Differentiation And Remyelination After Spinal Cord Injury, Ninth International Symposium On Healthy Aging. 2014. |
| Researcher : Deng W |
| Project Title: | Role of Bmi-1 in the persistence of Epstein-Barr virus (EBV) in nasopharyngeal epithelial cells |
| Investigator(s): | Deng W, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2012 |
| Completion Date: | 10/2013 |
| Project Title: | Role of Bmi-1 in the persistence of Epstein-Barr virus (EBV) in nasopharyngeal epithelial cells |
| Investigator(s): | Deng W, Tsao GSW, Huen MSY, Tsang CM |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 01/2013 |
| Project Title: | Role of short telomere profiles of cancer patients in determining cancer karyotype abnormalities |
| Investigator(s): | Deng W, Tsao GSW |
| Department: | School of Nursing |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2013 |
| Project Title: | Distinct whole-genome short telomere profiles of cancer patients in comparison with non-cancer individuals |
| Investigator(s): | Deng W, Tiwari AFY, Tsao GSW, Lam CLD |
| Department: | School of Nursing |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| List of Research Outputs |
| LEUNG O.N., Deng W., Ye T., Ngan H.Y.S., Tsao G.S.W., Cheung A.N.Y., Pang R.T.K. and Yeung W.S.B., miR-135a leads to cervical cancer cell transformation through regulation of β-catenin via a SIAH1-dependent ubiquitin proteosomal pathway, Carcinogenesis. 2014. |
| Researcher : Deng W. |
| Project Title: | Role of Bmi-1 in the persistence of Epstein-Barr virus (EBV) in nasopharyngeal epithelial cells |
| Investigator(s): | Deng W, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2012 |
| Completion Date: | 10/2013 |
| Project Title: | Role of Bmi-1 in the persistence of Epstein-Barr virus (EBV) in nasopharyngeal epithelial cells |
| Investigator(s): | Deng W, Tsao GSW, Huen MSY, Tsang CM |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 01/2013 |
| Project Title: | Role of short telomere profiles of cancer patients in determining cancer karyotype abnormalities |
| Investigator(s): | Deng W, Tsao GSW |
| Department: | School of Nursing |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2013 |
| Project Title: | Distinct whole-genome short telomere profiles of cancer patients in comparison with non-cancer individuals |
| Investigator(s): | Deng W, Tiwari AFY, Tsao GSW, Lam CLD |
| Department: | School of Nursing |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| List of Research Outputs |
| Researcher : Ellis-Behnke RG |
| Project Title: | The ADME of Self-assembling Nanomaterials |
| Investigator(s): | Ellis-Behnke RG |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2008 |
| Project Title: | Incorporation Dynamics of Additives and Self-assembly peptides (SAPs) at Nanoscale for Central Nervous System (CNS) Regeneration |
| Investigator(s): | Ellis-Behnke RG |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2009 |
| List of Research Outputs |
| SANG Y., Yang X., Ellis-Behnke R.G., So K.F. and Cheung R.T.F., A self-assembling peptide nanofiber scaffold reduces acute brain injury and improves functional recovery in a hypertensive rat model of intracerebral hemorrhage plus clot aspiration, The Conjoint Congress of the 5th World ICH Conference 2013 & 20th Annual Scientific Meeting of Hong Kong Neurosurgical Society. 2013, 106. |
| Sang L.Y.H., Liang Y., Li Y., Wong W.M., Tay D.K.C., So K.F., Ellis-Behnke R.G., Wu W. and Cheung R.T.F., A self-assembling nanomaterial reduces acute brain injury and enhances functional recovery in a rat model of intracerebral hemorrhage, Nanomedicine: Nanotechnology, Biology and Medicine. 2014, Epub on 2014-06-04. |
| Researcher : FENG Q |
| List of Research Outputs |
| FENG Q., Characterization of NG2+ macrophage in glaucoma - an investigation focusing on its origin and potential roles in ischemic retina. 2014, 168 pages. |
| Researcher : Feng W |
| Project Title: | Understanding the molecular mechanisms of TRAIP-dependent responses to genotoxic stress |
| Investigator(s): | Feng W, Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 12/2012 |
| Completion Date: | 05/2014 |
| Project Title: | Maintenance of Genome Stability 2014; A role of NIRR in replicative stress responses |
| Investigator(s): | Feng W |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 03/2014 |
| List of Research Outputs |
| Feng W. and Huen M.S.Y., A Role of NIRR in Replicative Stress Responses, Maintenance of Genome Stability 2014 - ABCAM. 2014. |
| Sy M.H., Guo Y., Feng W. and Huen M.S.Y., Role of ATM Signaling in PALB2-dependent DNA Damage Responses, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014. |
| Researcher : GUO R |
| List of Research Outputs |
| GUO R., Lin B., PAN J., Liong E.C., Fung M.L., So K.F., Youdim M.B.H. and Tipoe G.L., M30 multi-functional drug reduces apoptosis, oxidative stress and inflammation in CCl4 -induced acute liver injury animal model, The Physiology Symposium 2014, P9, 6/2014, 2014. |
| GUO R., Lin B., PAN J., Liong E.C., Fung M.L., So K.F., Youdim M.B.H. and Tipoe G.L., M30 multi-functional drug reduces apoptosis, oxidative stress and inflammation in CCl4-induced acute liver injury animal model, The Ninth International Symposium on Healthy Aging – Aging with Confidence, P64, 3/2014. |
| PAN J., GUO R., Liong E.C., Tipoe G.L. and Fung M.L., Intermittent hypoxia exacerbates lipid accumulation, inflammation and apoptosis via NADPH oxidase in a cell model of non-alcoholic fatty liver disease, The Physiology Symposium 2014, P27, 6/2014. |
| PAN J., GUO R., Liong E.C., Tipoe G.L. and Fung M.L., Oxidative stress induced by chronic intermittent hypoxia aggravates hepatic inflammation in nonalcoholic fatty liver disease (NAFLD), 18th Research Postgraduate Symposium, HKU P5.17, 12/2013. |
| PAN J., GUO R., Liong E.C., Tipoe G.L. and Fung M.L., Oxidative stress induced by intermittent hypoxia aggravates lipid accumulation and autophagy in a cell model of nonalcoholic fatty liver disease (NAFLD), The Ninth International Symposium on Healthy Aging – Aging with Confidence, P35, 3/2014. |
| PAN J., GUO R., Liong E.C., Tipoe G.L. and Fung M.L., Oxidative stress induced by intermittent hypoxia exacerbates lipid accumulation and inflammation in HepG2 cells. 2013 International Symposium on Physiomics &Taiwan, Hong Kong Physiology Symposium. Taipei, Taiwan. 2013. |
| PAN J., GUO R., Liong E.C., Tipoe G.L. and Fung M.L., Oxidative stress induced by intermittent hypoxia exacerbates lipid accumulation and inflammation in a cell model of non-alcoholic steatohepatitis. The 17th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, OP3, 11/2013, Journal of the Hong Kong College of Cardiology. 2013, 21(2):65. |
| WU F., GUO R., Tipoe G.L. and Fung M.L., Exercise attenuates left ventricular hypertrophy induced by high fat diet in rats, 18th Research Postgraduate Symposium, HKU, P5.25, 12/2013.. 2013. |
| WU F., GUO R., PAN J., Tipoe G.L. and Fung M.L., Involvement of autophagy in the effect of exercise on left ventricular hypertrophy induced by high fat diet in rats. The 17th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, CP5, Journal of the Hong Kong College of Cardiology. 2013, 21(2):70. |
| WU F., GUO R., PAN J., Tipoe G.L. and Fung M.L., Potential role of autophagy in the effect of exercise on left ventricular hypertrophy induced by high fat diet in rats. 2013 International Symposium on Physiomics &Taiwan , Hong Kong Physiology Symposium. Taipei, Taiwan,. 2013. |
| Researcher : GUO Y |
| List of Research Outputs |
| GUO Y. and Huen M.S.Y., Role of ATM Signaling in PALB2-dependent DNA Damage Responses, 20th Hong Kong International Cancer Congress, Hong Kong. 2013. |
| GUO Y. and Huen M.S.Y., Role of ATM Signaling in PALB2-dependent DNA Damage Responses, International Symposium on DNA Damage Response & Human Diseases - Beijing 2013 (isDDRHD-Beijing 2013). 2013. |
| Sy M.H., Guo Y., Feng W. and Huen M.S.Y., Role of ATM Signaling in PALB2-dependent DNA Damage Responses, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014. |
| Researcher : Guo Y |
| List of Research Outputs |
| GUO Y. and Huen M.S.Y., Role of ATM Signaling in PALB2-dependent DNA Damage Responses, 20th Hong Kong International Cancer Congress, Hong Kong. 2013. |
| GUO Y. and Huen M.S.Y., Role of ATM Signaling in PALB2-dependent DNA Damage Responses, International Symposium on DNA Damage Response & Human Diseases - Beijing 2013 (isDDRHD-Beijing 2013). 2013. |
| Sy M.H., Guo Y., Feng W. and Huen M.S.Y., Role of ATM Signaling in PALB2-dependent DNA Damage Responses, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014. |
| Researcher : HAN L |
| List of Research Outputs |
| HAN L., Li B., Tsao G.S.W. and Cheung A., Roles of miR-338-5p in downregulating Id-1 and inhibiting chemoresistance and cancer cell invasion, 20th Hong Kong International Cancer congress, November 14-15, 2013, Hong Kong. 2013, No. A21. |
| Liu J., HAN L., Li B., Yang J., Huen M.S.Y., Pan X., Tsao G.S.W. and Cheung A., F-box only protein 31 (FBX031) negatively regulates p38 mitogen-activated protein kinase (MAPK) signaling by mediating lysine 48-linked ubiquitination and degradation of mitogen-activated protein kinase kinase 6 (MKK6), Journal of Biological Chemistrry. 2014, 289: 21508-21518. |
| Researcher : HO YS |
| List of Research Outputs |
| Chang R.C.C., Wuwongse S., Wong S., Wong M.T.H., TSANG A.W.-.T., Zhang E., CHENG S.Y., Hung C.H.L., Lau W.M., Ho Y.S., So K.F. and Law A.C.K., Investigating biological mechanisms of corticosterone-induced neurodegeneration: Implication of how depression promotes cognitive impairment in Alzheimer's disease, Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 2013, 9 Issue 4 Supplement: 561-562. |
| Chang R.C.C., Ho Y.S., WONG T.H.G., TSANG A.W.-.T., WUWONGSE S., POON C.H., YOU R., HUANG C., Ng T.W., CHENG S.Y., Hung C.H.L., LEUNG Y., Yang X., Law A.C.K., Chiu K., Lau W.M., Mak J.C.W., Wong G.T.C., Lee S.M.Y. and Hoi M.P.M., Investigating mechanisms of risk factors for Alzheimer’s disease to learn how to prevent disease progression., International Alzheimer’s Disease Conference 2014. 24. |
| Chang R.C.C., TSANG A.W.-.T., Wong G.T.H., CHENG S.Y., Hung C.H.L., Ho Y.S. and Law A.C.K., Targeting depression to prevent dementia and Alzheimer's disease, International Conference on Pharmacology and Drug Development, Singapore 2013.. 2013, : 65. |
| HUANG C., Ho Y.S., Irwin M.G., Chang R.C.C. and Wong G.T.C., Comparing the effects of different anesthetics on tau protein phosphorylation., The 9th International Symposium of Healthy Aging. 2014, 59. |
| Ho Y.S., Hung C.H.L., Lau C.F. and Chang R.C.C., Targeting the unfolded protein response in Alzheimer’s disease – a potential approach to reduce tau pathology., The 9th International Symposium of Healthy Aging. 2014, 61. |
| POON C.H., Ho Y.S., Lok C.K.M., Leung M.C., Chiu K. and Chang R.C.C., Differential modulation of bacteria-induced sickness and inflammation by double stranded RNA-dependent protein kinase (PKR), Neuroscience 2013. Program # 277.01: Poster # EEE22. |
| POON C.H., Ho Y.S., Lok C.K.M., Chiu K. and Chang R.C.C., Effects of double stranded RNA-dependent protein kinase (PKR) on bacteria-mediated sickness and inflammation., The 9th International Symposium of Healthy Aging. 2014, 66. |
| WUWONGSE S., CHENG S.Y., WONG T.H.G., Hung C.H.L., ZHANG Q., HO Y.S., Law A.C.K. and Chang R.C.C., Effects of corticosterone and amyloid-beta on proteins essential for synaptic function: Implications for depression and Alzheimer's disease, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2013. |
| YOU R., Hung C.H.L., CHENG S.Y., Ho Y.S. and Chang R.C.C., Neuroprotective effects of honokiol in 6-hydroxydopamine-induced neurotoxicity., The 9th International Symposium of Healthy Aging. 2014, 61. |
| Researcher : Hau PM |
| List of Research Outputs |
| Yip Y.L., Pang P.S., Deng W., Tsang C.M., Zeng M., Hau P.M., Man C., Jin Y., Yuen A.P. and Tsao G.S.W., Efficient immortalization of primary nasopharyngeal epithelial cells for EBV infection study., PLoS One. 2013, 8: e78395. |
| Researcher : Ho MCT |
| List of Research Outputs |
| Xiao J., Ho M.C.T., Liong E.C., Nanji A.A., Leung T.M., Lau T.Y.H., Fung M.L. and Tipoe G.L., Epigallocatechin gallate attenuates fibrosis, oxidative stress, and inflammation in non-alcoholic fatty liver disease rat model through TGF/SMAD, PI3 K/Akt/FoxO1, and NF-kappa B pathways, European Journal of Nutrition. 2014, 53(1): 187-199. |
| Researcher : Ho YS |
| List of Research Outputs |
| Chang R.C.C., Wuwongse S., Wong S., Wong M.T.H., TSANG A.W.-.T., Zhang E., CHENG S.Y., Hung C.H.L., Lau W.M., Ho Y.S., So K.F. and Law A.C.K., Investigating biological mechanisms of corticosterone-induced neurodegeneration: Implication of how depression promotes cognitive impairment in Alzheimer's disease, Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 2013, 9 Issue 4 Supplement: 561-562. |
| Chang R.C.C., Ho Y.S., WONG T.H.G., TSANG A.W.-.T., WUWONGSE S., POON C.H., YOU R., HUANG C., Ng T.W., CHENG S.Y., Hung C.H.L., LEUNG Y., Yang X., Law A.C.K., Chiu K., Lau W.M., Mak J.C.W., Wong G.T.C., Lee S.M.Y. and Hoi M.P.M., Investigating mechanisms of risk factors for Alzheimer’s disease to learn how to prevent disease progression., International Alzheimer’s Disease Conference 2014. 24. |
| Chang R.C.C., TSANG A.W.-.T., Wong G.T.H., CHENG S.Y., Hung C.H.L., Ho Y.S. and Law A.C.K., Targeting depression to prevent dementia and Alzheimer's disease, International Conference on Pharmacology and Drug Development, Singapore 2013.. 2013, : 65. |
| HUANG C., Ho Y.S., Irwin M.G., Chang R.C.C. and Wong G.T.C., Comparing the effects of different anesthetics on tau protein phosphorylation., The 9th International Symposium of Healthy Aging. 2014, 59. |
| Ho Y.S., Hung C.H.L., Lau C.F. and Chang R.C.C., Targeting the unfolded protein response in Alzheimer’s disease – a potential approach to reduce tau pathology., The 9th International Symposium of Healthy Aging. 2014, 61. |
| POON C.H., Ho Y.S., Lok C.K.M., Leung M.C., Chiu K. and Chang R.C.C., Differential modulation of bacteria-induced sickness and inflammation by double stranded RNA-dependent protein kinase (PKR), Neuroscience 2013. Program # 277.01: Poster # EEE22. |
| POON C.H., Ho Y.S., Lok C.K.M., Chiu K. and Chang R.C.C., Effects of double stranded RNA-dependent protein kinase (PKR) on bacteria-mediated sickness and inflammation., The 9th International Symposium of Healthy Aging. 2014, 66. |
| WUWONGSE S., CHENG S.Y., WONG T.H.G., Hung C.H.L., ZHANG Q., HO Y.S., Law A.C.K. and Chang R.C.C., Effects of corticosterone and amyloid-beta on proteins essential for synaptic function: Implications for depression and Alzheimer's disease, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2013. |
| YOU R., Hung C.H.L., CHENG S.Y., Ho Y.S. and Chang R.C.C., Neuroprotective effects of honokiol in 6-hydroxydopamine-induced neurotoxicity., The 9th International Symposium of Healthy Aging. 2014, 61. |
| Researcher : Huen M.S.Y. |
| Project Title: | Molecular and functional characterisation of USP34, a ubiquitin specific peptidase involved in the DNA Damage Response |
| Investigator(s): | Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2011 |
| Project Title: | Characterization of C9ORF, a novel Axin1-associated factor implicated in Wnt/beta-catenin signaling. |
| Investigator(s): | Huen MSY, Sy MH |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2012 |
| Completion Date: | 05/2014 |
| Project Title: | Role of ATM Signaling in PALB2-dependent Homologous Recombination DNA Repair |
| Investigator(s): | Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | Early Career Scheme (ECS) |
| Start Date: | 10/2012 |
| Project Title: | Molecular and Functional Characterisation of DYRK1A in DNA Damage Signaling and Repair |
| Investigator(s): | Huen MSY, Sy MH |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2013 |
| Project Title: | Study Role of PCNA-binding protein TRAIP in Replicative Stress Responses and Tumor Suppression |
| Investigator(s): | Huen MSY, Feng W |
| Department: | Anatomy |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2014 |
| Project Title: | Study of the PALB2-Plk1 module in Cell Cycle Checkpoint Control and Maintenance of Genome Stability |
| Investigator(s): | Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 01/2014 |
| List of Research Outputs |
| Researcher : Huen MSY |
| Project Title: | Molecular and functional characterisation of USP34, a ubiquitin specific peptidase involved in the DNA Damage Response |
| Investigator(s): | Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 09/2011 |
| Project Title: | Characterization of C9ORF, a novel Axin1-associated factor implicated in Wnt/beta-catenin signaling. |
| Investigator(s): | Huen MSY, Sy MH |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2012 |
| Completion Date: | 05/2014 |
| Project Title: | Role of ATM Signaling in PALB2-dependent Homologous Recombination DNA Repair |
| Investigator(s): | Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | Early Career Scheme (ECS) |
| Start Date: | 10/2012 |
| Project Title: | Molecular and Functional Characterisation of DYRK1A in DNA Damage Signaling and Repair |
| Investigator(s): | Huen MSY, Sy MH |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 04/2013 |
| Project Title: | Study Role of PCNA-binding protein TRAIP in Replicative Stress Responses and Tumor Suppression |
| Investigator(s): | Huen MSY, Feng W |
| Department: | Anatomy |
| Source(s) of Funding: | NSFC/RGC Joint Research Scheme |
| Start Date: | 01/2014 |
| Project Title: | Study of the PALB2-Plk1 module in Cell Cycle Checkpoint Control and Maintenance of Genome Stability |
| Investigator(s): | Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 01/2014 |
| List of Research Outputs |
| Feng W. and Huen M.S.Y., A Role of NIRR in Replicative Stress Responses, Maintenance of Genome Stability 2014 - ABCAM. 2014. |
| GUO Y. and Huen M.S.Y., Role of ATM Signaling in PALB2-dependent DNA Damage Responses, 20th Hong Kong International Cancer Congress, Hong Kong. 2013. |
| GUO Y. and Huen M.S.Y., Role of ATM Signaling in PALB2-dependent DNA Damage Responses, International Symposium on DNA Damage Response & Human Diseases - Beijing 2013 (isDDRHD-Beijing 2013). 2013. |
| Han J., Liu T., Huen M.S.Y., Hu L., Chen Z. and Huang J., SIVA1 directs the E3 ubiquitin ligase RAD18 for PCNA monoubiquitination, Journal of Cell Biology. 2014, 205: 811-827. |
| Huen M.S.Y., Regulators of Ubiquitin Signaling at DNA Double-Strand Breaks, Asia GenomeCheck Conference, Ajou University Medical Center, South Korea. 2014. |
| Huen M.S.Y., Regulators of Ubiquitin Signaling at DNA Double-Strand Breaks, Society of Chinese Bioscientists in America - The 14th International Symposium. 2013. |
| Huen M.S.Y., Regulators of ubiquitin signaling at DNA double strand breaks, International Symposium on DNA Damage Response & Human Diseases - Beijing 2013. 2013. |
| LIU J., Li B., Yang J., Huen M.S.Y., Tsao G.S.W. and Cheung A., FBX031 negatively regulates p38 MAPK by promoting ubiquitination and degradation of MAP kinase kinase 6, 20th Hong Kong International Cancer Congress, November 14-15, 2013, Hong Kong. 2013, No. A16. |
| Liu J., HAN L., Li B., Yang J., Huen M.S.Y., Pan X., Tsao G.S.W. and Cheung A., F-box only protein 31 (FBX031) negatively regulates p38 mitogen-activated protein kinase (MAPK) signaling by mediating lysine 48-linked ubiquitination and degradation of mitogen-activated protein kinase kinase 6 (MKK6), Journal of Biological Chemistrry. 2014, 289: 21508-21518. |
| NG H.M. and Huen M.S.Y., Role of Deubiquitylase BRCC36 at DNA Double-Strand Breaks, 20th Hong Kong International Cancer Congress, Hong Kong. 2013. |
| Sy M.H., Guo Y., Feng W. and Huen M.S.Y., Role of ATM Signaling in PALB2-dependent DNA Damage Responses, 2014 Hong Kong Inter-University Biochemistry Postgraduate Symposium, Li Ka Shing Faculty of Medicine, The University of Hong Kong, June 14, 2014. |
| Sy M.H., Jiang J., O W.S., Deng Y. and Huen M.S.Y., The Ubiquitin Specific Protease USP34 promotes ubiquitin signaling at DNA double-strand breaks, Nucleic Acids Research. 2013, 41(18): 8572-80. |
| Researcher : Hugon J |
| Project Title: | Society for Neuroscience 30th Annual Meeting Tau Phosphorylation during neuronal Apoptosis Induced by NMDA Receptor Blockade: an in Vivo Study |
| Investigator(s): | Hugon J |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2000 |
| Researcher : Hung CHL |
| List of Research Outputs |
| CHENG S.Y., Hung C.H.L. and Chang R.C.C., Interplay of the ubiquitin-proteasome system and the autophagy-lysosomal pathway in an in vitro model of Alzheimer’s disease., The 9th International Symposium of Healthy Aging. 2014, 60. |
| CHENG S.Y., Hung C.H.L. and Chang R.C.C., Interplay of the ubiquitin-proteasome system and the autophagy-lysosome pathway in cultured neurons stressed by oligomeric b-amyloid peptide, Neuroscience 2013. Program # 40.13: Poster # G33. |
| Chang R.C.C., Wuwongse S., Wong S., Wong M.T.H., TSANG A.W.-.T., Zhang E., CHENG S.Y., Hung C.H.L., Lau W.M., Ho Y.S., So K.F. and Law A.C.K., Investigating biological mechanisms of corticosterone-induced neurodegeneration: Implication of how depression promotes cognitive impairment in Alzheimer's disease, Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 2013, 9 Issue 4 Supplement: 561-562. |
| Chang R.C.C., Ho Y.S., WONG T.H.G., TSANG A.W.-.T., WUWONGSE S., POON C.H., YOU R., HUANG C., Ng T.W., CHENG S.Y., Hung C.H.L., LEUNG Y., Yang X., Law A.C.K., Chiu K., Lau W.M., Mak J.C.W., Wong G.T.C., Lee S.M.Y. and Hoi M.P.M., Investigating mechanisms of risk factors for Alzheimer’s disease to learn how to prevent disease progression., International Alzheimer’s Disease Conference 2014. 24. |
| Chang R.C.C., TSANG A.W.-.T., Wong G.T.H., CHENG S.Y., Hung C.H.L., Ho Y.S. and Law A.C.K., Targeting depression to prevent dementia and Alzheimer's disease, International Conference on Pharmacology and Drug Development, Singapore 2013.. 2013, : 65. |
| Ho Y.S., Hung C.H.L., Lau C.F. and Chang R.C.C., Targeting the unfolded protein response in Alzheimer’s disease – a potential approach to reduce tau pathology., The 9th International Symposium of Healthy Aging. 2014, 61. |
| Hung C.H.L., CHENG S.Y., Lee S.M.Y. and Chang R.C.C., A reciprocal relationship between oxygen species and mitochondrial dynamics in neurodegeneration., The 9th International Symposium of Healthy Aging. 2014, 59. |
| WONG T.H.G., Hung C.H.L., TSANG A.W.-.T., Chang R.C.C. and Law A.C.K., Microtubule dysfunction in corticosterone and oligomeric beta-amyloid in vitro model and its effect on actin morphology., The 9th International Symposium of Healthy Aging. 2014, 50. |
| WUWONGSE S., CHENG S.Y., WONG T.H.G., Hung C.H.L., ZHANG Q., HO Y.S., Law A.C.K. and Chang R.C.C., Effects of corticosterone and amyloid-beta on proteins essential for synaptic function: Implications for depression and Alzheimer's disease, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2013. |
| Wong G.T.H., Hung C.H.L., Law A.C.K. and Chang R.C.C., Oligomeric beta-amyloid and corticosterone trigger similar morphologic and dynamic changes in microtubules of cultured hippocampal neurons, Neuroscience 2013. Program # 40.11: Poster # G31. |
| YOU R., Hung C.H.L., CHENG S.Y., Ho Y.S. and Chang R.C.C., Neuroprotective effects of honokiol in 6-hydroxydopamine-induced neurotoxicity., The 9th International Symposium of Healthy Aging. 2014, 61. |
| Researcher : KWAN KK |
| List of Research Outputs |
| KWAN K.K. and Ching Y.P., Role of PAK4 in Extracellular matrix (ECM) Degradation, In: European Molecular Biology Laboratory, EMBO|EMBL Symposium: Tumour microenvironment and signalling 2014. Heidelberg. |
| Researcher : Kwan ALH |
| List of Research Outputs |
| Chan L.K., Chan O.O.C., Kwan A.L.H., So K.F., Tipoe G.L., Tsao G.S.W. and Wong P.W.L., Faculty Knowledge Exchange Award, The University of Hong Kong. 2014. |
| Researcher : LAU KLK |
| List of Research Outputs |
| LAU K.L.K., Human pluripotent stem cells as a source of dendritic cells to induce immune tolerance. 2014, 92 pages. |
| Researcher : LAU MY |
| List of Research Outputs |
| Tsao G.S.W., Yip Y.L., Tsang C.M., Pang P.S., LAU M.Y., Zhang G. and Lo K.W., Etiological factors of nasopharyngeal carcinoma, Oral Oncology. 2014, 50: 330-8. |
| Researcher : LEE CD |
| List of Research Outputs |
| Lau W.M., LEE C.D. and So K.F., Neurogenic hypothesis and psychiatric disorders, Chinese Science Bulletin. 2013, 58(26): 3188-3198. |
| Researcher : LEUNG Y |
| List of Research Outputs |
| Chang R.C.C., Ho Y.S., WONG T.H.G., TSANG A.W.-.T., WUWONGSE S., POON C.H., YOU R., HUANG C., Ng T.W., CHENG S.Y., Hung C.H.L., LEUNG Y., Yang X., Law A.C.K., Chiu K., Lau W.M., Mak J.C.W., Wong G.T.C., Lee S.M.Y. and Hoi M.P.M., Investigating mechanisms of risk factors for Alzheimer’s disease to learn how to prevent disease progression., International Alzheimer’s Disease Conference 2014. 24. |
| LEUNG Y., Chiu K. and Chang R.C.C., A comparison between medial forebrain bundle injection and striatal injection in 6-OHDA model of Parkinson’s disease., The 9th International Symposium of Healthy Aging. 2014, 59. |
| LEUNG Y., Chiu K. and Chang R.C.C., A comparison between medial forebrain bundle injection and striatal injection in 6-OHDA model of Parkinson’s disease, The 9th International Symposium of Healthy Aging. 2014. |
| Researcher : LIN W |
| List of Research Outputs |
| Tsang C.M., Cheung Y.C., Lui W.Y.V., Yip Y.L., Zhang G., LIN W., Cheung K.C.P., Feng Y. and Tsao G.S.W., Berberine suppresses tumorigenicity and growth of nasopharyngeal carcinoma cells by inhibiting STAT3 activation induced by tumor associated fibroblasts, BMC Cancer. 2013, 13: 619. |
| Researcher : LIU J |
| List of Research Outputs |
| LIU J., Li B., Yang J., Huen M.S.Y., Tsao G.S.W. and Cheung A., FBX031 negatively regulates p38 MAPK by promoting ubiquitination and degradation of MAP kinase kinase 6, 20th Hong Kong International Cancer Congress, November 14-15, 2013, Hong Kong. 2013, No. A16. |
| LIU J., Role of FBXO31 in regulating MAPK-mediated genotoxic stress response and cancer cell survival. 2014, 168 pages. |
| Liu J., HAN L., Li B., Yang J., Huen M.S.Y., Pan X., Tsao G.S.W. and Cheung A., F-box only protein 31 (FBX031) negatively regulates p38 mitogen-activated protein kinase (MAPK) signaling by mediating lysine 48-linked ubiquitination and degradation of mitogen-activated protein kinase kinase 6 (MKK6), Journal of Biological Chemistrry. 2014, 289: 21508-21518. |
| Researcher : Lai WL |
| Project Title: | An investigation on the role of Tax1 binding protein 2 in the DNA damage response in hepatocellular carcinoma |
| Investigator(s): | Lai WL, Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2013 |
| List of Research Outputs |
| Wong L.L.Y., Lam P.Y., WONG Y.N., Lai W.L., Liu M.H.F., Yeung L.L. and Ching Y.P., IPA-3 inhibits the growth of liver cancer cells by suppressing PAK1 and NF-kB activation, PLOS ONE. 2013, 8(7), pp: e68843. |
| Researcher : Lam PY |
| List of Research Outputs |
| Wong L.L.Y., Lam P.Y., WONG Y.N., Lai W.L., Liu M.H.F., Yeung L.L. and Ching Y.P., IPA-3 inhibits the growth of liver cancer cells by suppressing PAK1 and NF-kB activation, PLOS ONE. 2013, 8(7), pp: e68843. |
| Researcher : Lau WM |
| List of Research Outputs |
| Chang R.C.C., Wuwongse S., Wong S., Wong M.T.H., TSANG A.W.-.T., Zhang E., CHENG S.Y., Hung C.H.L., Lau W.M., Ho Y.S., So K.F. and Law A.C.K., Investigating biological mechanisms of corticosterone-induced neurodegeneration: Implication of how depression promotes cognitive impairment in Alzheimer's disease, Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 2013, 9 Issue 4 Supplement: 561-562. |
| Chang R.C.C., Ho Y.S., WONG T.H.G., TSANG A.W.-.T., WUWONGSE S., POON C.H., YOU R., HUANG C., Ng T.W., CHENG S.Y., Hung C.H.L., LEUNG Y., Yang X., Law A.C.K., Chiu K., Lau W.M., Mak J.C.W., Wong G.T.C., Lee S.M.Y. and Hoi M.P.M., Investigating mechanisms of risk factors for Alzheimer’s disease to learn how to prevent disease progression., International Alzheimer’s Disease Conference 2014. 24. |
| Lau W.M., LEE C.D. and So K.F., Neurogenic hypothesis and psychiatric disorders, Chinese Science Bulletin. 2013, 58(26): 3188-3198. |
| Researcher : Lee NPY |
| Project Title: | Tight-junction claudin-19 in kidney development and renal disease |
| Investigator(s): | Lee NPY, Luk JMC, Tam PC |
| Department: | Surgery |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2004 |
| Project Title: | Elucidating the role of cadherin-17 on proliferation and apoptosis of liver cancer cells |
| Investigator(s): | Lee NPY |
| Department: | Surgery |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2012 |
| Completion Date: | 11/2013 |
| Project Title: | An Investigation into the Pre-clinical Efficacy of Monoclonal Antibody against Cadherin-17 and its Combined Treatment with Chemotherapeutic Drugs using Live Imaging in an Orthotopic Tumor Xenograft Model (ITS/280/11) |
| Investigator(s): | Lee NPY, Sun S, Fan ST |
| Department: | Surgery |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 06/2012 |
| Project Title: | An Investigation into the Pre-clinical Efficacy of Monoclonal Antibody against Cadherin-17 and its Combined Treatment with Chemotherapeutic Drugs using Live Imaging in an Orthotopic Tumor Xenograft Model |
| Investigator(s): | Lee NPY, Sun S, Fan ST |
| Department: | Surgery |
| Source(s) of Funding: | Innovation and Technology Support Programme (Tier 3) |
| Start Date: | 06/2012 |
| Completion Date: | 02/2014 |
| Project Title: | An Investigation into the Pre-clinical Efficacy of Monoclonal Antibody against Cadherin-17 and its Combined Treatment with Chemotherapeutic Drugs using Live Imaging in an Orthotopic Tumor Xenograft Model (ITS/280/11) |
| Investigator(s): | Lee NPY, Sun S, Fan ST |
| Department: | Surgery |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 06/2012 |
| Project Title: | An Investigation into the Pre-clinical Efficacy of Monoclonal Antibody against Cadherin-17 and its Combined Treatment with Chemotherapeutic Drugs using Live Imaging in an Orthotopic Tumor Xenograft Model |
| Investigator(s): | Lee NPY, Sun S, Fan ST |
| Department: | Surgery |
| Source(s) of Funding: | Innovation and Technology Fund Internship Programme |
| Start Date: | 04/2013 |
| Project Title: | Characterizing the tumorigenic properties of cyclin E1 in liver cancer |
| Investigator(s): | Lee NPY |
| Department: | Surgery |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2013 |
| Project Title: | A study of hepatitis B virus integration events into human cyclin E1 |
| Investigator(s): | Lee NPY |
| Department: | Surgery |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| List of Research Outputs |
| Sung Y.J.C., Lee N.P.Y. and El-Nezamy H.S., Regulation of T helper subsets by bacteria: An approach for the treatment of hepatocellular carcinoma. , 14th International Conference of FFC - Second International Symposium of ASFFBC: Functional Foods and Bioactive Compounds in the Management of Chronic Inflammation: Science and Practical Application, University of California, Los Angeles (UCLA), USA. 2013. |
| Researcher : Lee SMY |
| List of Research Outputs |
| Chang R.C.C., Ho Y.S., WONG T.H.G., TSANG A.W.-.T., WUWONGSE S., POON C.H., YOU R., HUANG C., Ng T.W., CHENG S.Y., Hung C.H.L., LEUNG Y., Yang X., Law A.C.K., Chiu K., Lau W.M., Mak J.C.W., Wong G.T.C., Lee S.M.Y. and Hoi M.P.M., Investigating mechanisms of risk factors for Alzheimer’s disease to learn how to prevent disease progression., International Alzheimer’s Disease Conference 2014. 24. |
| Researcher : Leung MC |
| List of Research Outputs |
| Chiu K., Leung M.C., Leung I.Y.P., Lok C.K.M., Turner R., Matsuoka Y., So K.F. and Chang R.C.C., Morphometric analysis of the retina in a triple-transgenic model of Alzheimer's disease, Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 2013, 9, Issue 4, Supplement: 435. |
| POON C.H., Ho Y.S., Lok C.K.M., Leung M.C., Chiu K. and Chang R.C.C., Differential modulation of bacteria-induced sickness and inflammation by double stranded RNA-dependent protein kinase (PKR), Neuroscience 2013. Program # 277.01: Poster # EEE22. |
| Researcher : Leung TM |
| List of Research Outputs |
| Xiao J., Ho M.C.T., Liong E.C., Nanji A.A., Leung T.M., Lau T.Y.H., Fung M.L. and Tipoe G.L., Epigallocatechin gallate attenuates fibrosis, oxidative stress, and inflammation in non-alcoholic fatty liver disease rat model through TGF/SMAD, PI3 K/Akt/FoxO1, and NF-kappa B pathways, European Journal of Nutrition. 2014, 53(1): 187-199. |
| Researcher : Li B |
| Project Title: | Suppressive effects of Id1-targeting microRNAs in metastasis of esophageal cancer |
| Investigator(s): | Li B, Cheung A |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2013 |
| Project Title: | Markers in Cancer; Id1/IGF2/IGF1R/PI3K/AKT signaling cascade as functional markers and therapeutic targets in esophageal cancer |
| Investigator(s): | Li B |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 11/2013 |
| Completion Date: | 11/2013 |
| List of Research Outputs |
| Cheung A., Xu W., Li B., Tsao G.S.W. and Chan K.W., Id1 induced IGF2 promotes bidirectional interaction between oesophageal cancer cells and fibroblasts in the tumour microenvironment, European Cancer Congress, Amsterdam, 27 September - 1 October 2013, Holland. 2013, 392. |
| HAN L., Li B., Tsao G.S.W. and Cheung A., Roles of miR-338-5p in downregulating Id-1 and inhibiting chemoresistance and cancer cell invasion, 20th Hong Kong International Cancer congress, November 14-15, 2013, Hong Kong. 2013, No. A21. |
| LIU J., Li B., Yang J., Huen M.S.Y., Tsao G.S.W. and Cheung A., FBX031 negatively regulates p38 MAPK by promoting ubiquitination and degradation of MAP kinase kinase 6, 20th Hong Kong International Cancer Congress, November 14-15, 2013, Hong Kong. 2013, No. A16. |
| Li B., Tsao G.S.W., Chan K.W., Ludwig D.L., Novosyadlyy R., Li Y.Y., He Q.Y. and Cheung A., Id1-induced IGF-II and its autocrine/endocrine promotion of esophageal cancer progression and chemoresistance-implications for IGF-II and IGF-IR-targeted therapy, Clinical Cancer Research. 2014, 2651-2662. |
| Li B., Tsao G.S.W., Chan K.W. and Cheung A., Id1/IGF2/IGF1R/P13K/AKT signaling cascade as functional markers and therapeutic targets in esophageal cancer, European Journal of Cancer. 2013, 49 Suppl. 4: S23 MC13-0039. |
| Liu J., HAN L., Li B., Yang J., Huen M.S.Y., Pan X., Tsao G.S.W. and Cheung A., F-box only protein 31 (FBX031) negatively regulates p38 mitogen-activated protein kinase (MAPK) signaling by mediating lysine 48-linked ubiquitination and degradation of mitogen-activated protein kinase kinase 6 (MKK6), Journal of Biological Chemistrry. 2014, 289: 21508-21518. |
| XU W., Li B., Tsao G.S.W., Chan K.W. and Cheung A., Mechanistic study of the interactions between Id1-overexpressing esophageal cancer cells and fibroblasts in the tumor microenvironment, 2013 NCRI Cancer Conference, 3-6 November 2013, Liverpool, U. K.. 2013, A191. |
| XU W., Li B., Tsao G.S.W., Chan K.W. and Cheung A., Suppression of angiogenesis and esophageal cancer progression by selective targeting of hematopoietic and endothelial progenitor cells, 18th International Vascular Biology Meeting, April 14-17, 2014, Kyoto, Japan. 2014, P-513. |
| Researcher : Li H |
| List of Research Outputs |
| Chu P.H.W., Li H., Chin M.P., So K.F. and Chan H.H.L., Effect of Lycium Barbarum (Wolfberry) polysaccharides on preserving retinal function after partial optic nerve transection, PLoS One. 2013, 8 Issue 12: e81339. |
| Li H., Liang Y., Chiu K., Yuan Q., Lin B., Chang R.C.C. and So K.F., Lycium Barbarum (wolfberry) reduces secondary degeneration and oxidative stress, and inhibits JNK pathway in retina after partial optic nerve transection, PLoS. 2013, 8 issue 7 e68881: 1-13. |
| Researcher : Li YY |
| List of Research Outputs |
| Li B., Tsao G.S.W., Chan K.W., Ludwig D.L., Novosyadlyy R., Li Y.Y., He Q.Y. and Cheung A., Id1-induced IGF-II and its autocrine/endocrine promotion of esophageal cancer progression and chemoresistance-implications for IGF-II and IGF-IR-targeted therapy, Clinical Cancer Research. 2014, 2651-2662. |
| Researcher : Liang Y |
| List of Research Outputs |
| Li H., Liang Y., Chiu K., Yuan Q., Lin B., Chang R.C.C. and So K.F., Lycium Barbarum (wolfberry) reduces secondary degeneration and oxidative stress, and inhibits JNK pathway in retina after partial optic nerve transection, PLoS. 2013, 8 issue 7 e68881: 1-13. |
| Sang L.Y.H., Liang Y., Li Y., Wong W.M., Tay D.K.C., So K.F., Ellis-Behnke R.G., Wu W. and Cheung R.T.F., A self-assembling nanomaterial reduces acute brain injury and enhances functional recovery in a rat model of intracerebral hemorrhage, Nanomedicine: Nanotechnology, Biology and Medicine. 2014, Epub on 2014-06-04. |
| Sang Y., Liang Y., Behnke E.R.G., So K.F. and Cheung R.T.F., A self-assembling peptide nanofiber scaffold reduces acute brain injury and improves functional recovery in a hypertensive rat model of intracranial hemorrhage plus clot aspiration, The 5th World Conference of Intracerebral Hemorrhage & 20th Annual Scientific Meeting of the Hong Kong Neurosurgical Society, Hong Kong, China, 2-4 November 2013. |
| Zhou I.Y., Liang Y., Chan R.W., GAO P., Cheng J.S., Hu Y., So K.F. and Wu E.X., NeuroImage, Brain resting-state functional MRI connectivity: morphological foundation and plasticity.. 2014, 84: 1-10. |
| Zhou Y., Liang Y., Chan R.W., Gao P.P., Cheng J.S., Hu Y., So K.F. and Wu E.X., Brain resting-state functional MRI connectivity: Morphological foundation and plasticity, NeuroImage. 2013, 84: 1-10. |
| Researcher : Liao S |
| Project Title: | Molecular regulation of meiotic resumption and chromosome segregation in mouse and human oocytes |
| Investigator(s): | Liao S |
| Department: | Obstetrics & Gynaecology |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2014 |
| List of Research Outputs |
| Liao S., Cheung K.H., Cheung M.P.L., To J.Y.T., O W.S. and Tang F., Adrenomedullin increased the short-circuit current in the pig oviduct through chloride channels via the CGRP receptor: Mediation by cAMP and calcium ions but not by nitric oxide, Biology of Reproduction. 2013, 89(4): 99, 1-6. |
| Researcher : Lin B |
| Project Title: | Restoring visual function after photoreceptor degeneration: ectopic expression of photosensitive proteins in retinal neurons. |
| Investigator(s): | Lin B |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2010 |
| Completion Date: | 09/2013 |
| Project Title: | Mechanisms of the Secondary Degeneration of Retinal Cone Photoreceptors in Retinitis Pigmentosa (RP) |
| Investigator(s): | Lin B |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2011 |
| Completion Date: | 06/2014 |
| Project Title: | Protection and Restoration of cone photoreceptors by a novel multifunctional drug and its neuroprotective molecular mechanisms in one mouse model of retinitis pigmentosa |
| Investigator(s): | Lin B |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 01/2012 |
| Completion Date: | 12/2013 |
| Project Title: | Artificial photoreceptors created by using an optogenetic approach |
| Investigator(s): | Lin B |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Applied Research |
| Start Date: | 06/2013 |
| Completion Date: | 06/2014 |
| Project Title: | The role of gap junctions in retinal degeneration |
| Investigator(s): | Lin B |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2013 |
| Project Title: | Modulation of the PTEN/mTOR pathway enhances the survival of cone photoreceptors in retinal degeneration disorders |
| Investigator(s): | Lin B, Ching YP, Huang X |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 12/2013 |
| Project Title: | The Association for Research in Vision and Ophthalmology (ARVO) 2014 Annual Meeting,; Suppression of microglial activation is neuroprotective in a mouse model of human retinitis pigmentosa |
| Investigator(s): | Lin B |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 05/2014 |
| Project Title: | Cyclooxygenase-1 deletion enhances cone photoreceptor survival in retinal degeneration disorders |
| Investigator(s): | Lin B |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| List of Research Outputs |
| GUO R., Lin B., PAN J., Liong E.C., Fung M.L., So K.F., Youdim M.B.H. and Tipoe G.L., M30 multi-functional drug reduces apoptosis, oxidative stress and inflammation in CCl4 -induced acute liver injury animal model, The Physiology Symposium 2014, P9, 6/2014, 2014. |
| GUO R., Lin B., PAN J., Liong E.C., Fung M.L., So K.F., Youdim M.B.H. and Tipoe G.L., M30 multi-functional drug reduces apoptosis, oxidative stress and inflammation in CCl4-induced acute liver injury animal model, The Ninth International Symposium on Healthy Aging – Aging with Confidence, P64, 3/2014. |
| Li H., Liang Y., Chiu K., Yuan Q., Lin B., Chang R.C.C. and So K.F., Lycium Barbarum (wolfberry) reduces secondary degeneration and oxidative stress, and inhibits JNK pathway in retina after partial optic nerve transection, PLoS. 2013, 8 issue 7 e68881: 1-13. |
| PENG B., Xiao J., WANG K., So K.F., Tipoe G.L. and Lin B., Suppression of Microglial Activation Is Neuroprotective in a Mouse Model of Human Retinitis Pigmentosa. The Journal of Neuroscience, 2014, 34: 8139-8150. |
| WANG K., PENG B. and Lin B., Fractalkine receptor regulates microglial neurotoxicity in an experimental mouse glaucoma model, Glia. Wiley Periodicals, Inc., 2014, 62: 1943-1954. |
| Researcher : Ling MT |
| Project Title: | The regulation and role of Id-1 in prostate cancer progression |
| Investigator(s): | Ling MT, Wong YC, Wang X |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2005 |
| Project Title: | The role of EMI1 in prostate carcinogenesis |
| Investigator(s): | Ling MT, Wang X |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 02/2007 |
| Project Title: | The role of Daxx in chromosome instability and prostate carcinogenesis |
| Investigator(s): | Ling MT, Wong YC |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2008 |
| Project Title: | Effect of Tocotrienol in the inhibition of hormone refractory prostate cancer |
| Investigator(s): | Ling MT, Wong YC |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Applied Research |
| Start Date: | 08/2008 |
| Researcher : Liong EC |
| List of Research Outputs |
| GUO R., Lin B., PAN J., Liong E.C., Fung M.L., So K.F., Youdim M.B.H. and Tipoe G.L., M30 multi-functional drug reduces apoptosis, oxidative stress and inflammation in CCl4 -induced acute liver injury animal model, The Physiology Symposium 2014, P9, 6/2014, 2014. |
| GUO R., Lin B., PAN J., Liong E.C., Fung M.L., So K.F., Youdim M.B.H. and Tipoe G.L., M30 multi-functional drug reduces apoptosis, oxidative stress and inflammation in CCl4-induced acute liver injury animal model, The Ninth International Symposium on Healthy Aging – Aging with Confidence, P64, 3/2014. |
| Lam S.S.Y., liu Y., Ng K.M., Liong E.C., Tipoe G.L., Leung P.S. and Fung M.L., Upregulation of a local renin-angiotensin system in the rat carotid body during chronic intermittent hypoxia, Experimental Physiology. 2014, 99: 220-231. |
| PAN J., GUO R., Liong E.C., Tipoe G.L. and Fung M.L., Intermittent hypoxia exacerbates lipid accumulation, inflammation and apoptosis via NADPH oxidase in a cell model of non-alcoholic fatty liver disease, The Physiology Symposium 2014, P27, 6/2014. |
| PAN J., GUO R., Liong E.C., Tipoe G.L. and Fung M.L., Oxidative stress induced by chronic intermittent hypoxia aggravates hepatic inflammation in nonalcoholic fatty liver disease (NAFLD), 18th Research Postgraduate Symposium, HKU P5.17, 12/2013. |
| PAN J., GUO R., Liong E.C., Tipoe G.L. and Fung M.L., Oxidative stress induced by intermittent hypoxia aggravates lipid accumulation and autophagy in a cell model of nonalcoholic fatty liver disease (NAFLD), The Ninth International Symposium on Healthy Aging – Aging with Confidence, P35, 3/2014. |
| PAN J., GUO R., Liong E.C., Tipoe G.L. and Fung M.L., Oxidative stress induced by intermittent hypoxia exacerbates lipid accumulation and inflammation in HepG2 cells. 2013 International Symposium on Physiomics &Taiwan, Hong Kong Physiology Symposium. Taipei, Taiwan. 2013. |
| PAN J., GUO R., Liong E.C., Tipoe G.L. and Fung M.L., Oxidative stress induced by intermittent hypoxia exacerbates lipid accumulation and inflammation in a cell model of non-alcoholic steatohepatitis. The 17th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, OP3, 11/2013, Journal of the Hong Kong College of Cardiology. 2013, 21(2):65. |
| Xiao J., Ho M.C.T., Liong E.C., Nanji A.A., Leung T.M., Lau T.Y.H., Fung M.L. and Tipoe G.L., Epigallocatechin gallate attenuates fibrosis, oxidative stress, and inflammation in non-alcoholic fatty liver disease rat model through TGF/SMAD, PI3 K/Akt/FoxO1, and NF-kappa B pathways, European Journal of Nutrition. 2014, 53(1): 187-199. |
| Xiao J., Liong E.C., Chang R.C.C., Fung M.L., Xu A.M., So K.F. and Tipoe G.L., Lycium barbarum polysaccharides protect rat liver from non-alcoholic steatohepatitis-induced injury, Nutrition and Diabetes, Doi:10.1038/nutd.2013.22. 2013, 3,e81. |
| Xiao J., Wang J., Xing F., Han T., Jiao R., Liong E.C., Fung M.L., So K.F. and Tipoe G.L., Zeaxanthin dipalmitate therapeutically improves hepatic functions in an alcoholic fatty liver disease model through modulating MAPK pathway, PLOS ONE. 2014, 9(4): e95214. |
| Researcher : Liu J |
| List of Research Outputs |
| LIU J., Li B., Yang J., Huen M.S.Y., Tsao G.S.W. and Cheung A., FBX031 negatively regulates p38 MAPK by promoting ubiquitination and degradation of MAP kinase kinase 6, 20th Hong Kong International Cancer Congress, November 14-15, 2013, Hong Kong. 2013, No. A16. |
| LIU J., Role of FBXO31 in regulating MAPK-mediated genotoxic stress response and cancer cell survival. 2014, 168 pages. |
| Liu J., HAN L., Li B., Yang J., Huen M.S.Y., Pan X., Tsao G.S.W. and Cheung A., F-box only protein 31 (FBX031) negatively regulates p38 mitogen-activated protein kinase (MAPK) signaling by mediating lysine 48-linked ubiquitination and degradation of mitogen-activated protein kinase kinase 6 (MKK6), Journal of Biological Chemistrry. 2014, 289: 21508-21518. |
| Researcher : Liu MHF |
| List of Research Outputs |
| Wong L.L.Y., Lam P.Y., WONG Y.N., Lai W.L., Liu M.H.F., Yeung L.L. and Ching Y.P., IPA-3 inhibits the growth of liver cancer cells by suppressing PAK1 and NF-kB activation, PLOS ONE. 2013, 8(7), pp: e68843. |
| Researcher : Lok CKM |
| List of Research Outputs |
| Chang R.C.C., Chiu K., Lok C.K.M., Turner R.S., Matsuoka Y. and So K.F., Examination of the retina in triple transgenic mice of Alzheimer's disease, Neuroscience 2013. Program # 710.13: Poster # G7. |
| Chiu K., Leung M.C., Leung I.Y.P., Lok C.K.M., Turner R., Matsuoka Y., So K.F. and Chang R.C.C., Morphometric analysis of the retina in a triple-transgenic model of Alzheimer's disease, Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 2013, 9, Issue 4, Supplement: 435. |
| Chiu K., Lok C.K.M., So K.F. and Chang R.C.C., Potential significance of chrysin as a neuroprotective agent to retinal ganglion cells in a rat model of glaucoma, The 6th Chinese Congress of Research in Vision and Ophthalmology. 2014. |
| POON C.H., Ho Y.S., Lok C.K.M., Leung M.C., Chiu K. and Chang R.C.C., Differential modulation of bacteria-induced sickness and inflammation by double stranded RNA-dependent protein kinase (PKR), Neuroscience 2013. Program # 277.01: Poster # EEE22. |
| POON C.H., Ho Y.S., Lok C.K.M., Chiu K. and Chang R.C.C., Effects of double stranded RNA-dependent protein kinase (PKR) on bacteria-mediated sickness and inflammation., The 9th International Symposium of Healthy Aging. 2014, 66. |
| Researcher : Ma SKY |
| Project Title: | Functional and molecular characterization of TP53INP1 as a novel metastasis suppressor in hepatocellular carcinoma |
| Investigator(s): | Ma SKY |
| Department: | Pathology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 03/2012 |
| Completion Date: | 02/2014 |
| Project Title: | Centre for MicroRNA Study - Basic Research and Clinical Potentials in Cancer |
| Investigator(s): | Ma SKY, Wong AST |
| Department: | Pathology |
| Source(s) of Funding: | Collaborative Research Fund (CRF) - Group Research Project |
| Start Date: | 06/2012 |
| Project Title: | Characterization and clinical evaluation of the metastasis-suppressing function of TP53INP1 in hepatocellular carcinoma |
| Investigator(s): | Ma SKY |
| Department: | Pathology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2012 |
| Project Title: | Hepatitis B virus promotes hepatocarcinogenesis through induction of CD133+ cancer stem cells/tumor-initiating cells |
| Investigator(s): | Ma SKY, Guan X |
| Department: | Clinical Oncology |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 01/2013 |
| Project Title: | Epigenetic modulation of CD133+ liver cancer stem cells by chromatin-modifying enzymes |
| Investigator(s): | Ma SKY |
| Department: | Clinical Oncology |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2013 |
| Completion Date: | 04/2014 |
| Project Title: | Significance of Annexin A3 in CD133+ Cancer-Initiating Cells-Driven Hepatocellular Carcinoma |
| Investigator(s): | Ma SKY, Chan KW |
| Department: | Clinical Oncology |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 12/2013 |
| Project Title: | Outstanding Young Researcher Award 2012-13 |
| Investigator(s): | Ma SKY |
| Department: | Anatomy |
| Source(s) of Funding: | Outstanding Young Researcher Award |
| Start Date: | 01/2014 |
| Project Title: | American Association for Cancer Research Annual Meeting 2014; Annexin A3 is a therapeutic target for CD133+ liver cancer stem cells |
| Investigator(s): | Ma SKY |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2014 |
| Completion Date: | 04/2014 |
| Project Title: | A multidisciplinary study on hepatic cancer stem cells |
| Investigator(s): | Ma SKY |
| Department: | Anatomy |
| Source(s) of Funding: | Croucher Innovation Awards |
| Start Date: | 04/2014 |
| Project Title: | The use of anti-annexin A3 monoclonal antibody for the treatment of liver cancer |
| Investigator(s): | Ma SKY |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Applied Research |
| Start Date: | 05/2014 |
| Project Title: | miR-1246 and Wnt/β-catenin interaction in the control of CD133+ liver cancer stem cells driven hepatocellular carcinoma |
| Investigator(s): | Ma SKY |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2014 |
| List of Research Outputs |
| Liu L., Dai Y., CHEN J., Zeng T., Li Y., Chen L., Zhu Y.H., Li J., Li Y., Ma S.K.Y., Xie D., Yuan Y.F. and Guan X., Maelstrom promotes hepatocellular carcinoma metastasis by inducing epithelial-mesenchymal transition by way of Akt/GSK-3b signaling, Hepatology. 2014, 59: 531-543. |
| Ma S.K.Y., 2012-2013 Outstanding Young Researcher Award, The University of Hong Kong, The University of Hong Kong. 2014. |
| Ma S.K.Y., Biology and clinical implications of liver cancer stem cells, The 1st International Symposium of Catholic Liver Research Centre, The Catholic University of Korea, Seoul, Korea. 2013. |
| Ma S.K.Y., Croucher Innovation Award, The Croucher Foundation, Hong Kong. 2014. |
| Ma S.K.Y., Editorial Board Member, World Journal of Biological Chemistry. 2013. |
| Ma S.K.Y., Esophageal cancer stem cells, Shantou University Medical College, Shantou, China. 2014. |
| Ma S.K.Y., Reviewer Editorial Board, Frontiers in Molecular Medicine. 2013. |
| Researcher : NG HM |
| List of Research Outputs |
| NG H.M. and Huen M.S.Y., Role of Deubiquitylase BRCC36 at DNA Double-Strand Breaks, 20th Hong Kong International Cancer Congress, Hong Kong. 2013. |
| Researcher : Ng TW |
| List of Research Outputs |
| Chang R.C.C., Ho Y.S., WONG T.H.G., TSANG A.W.-.T., WUWONGSE S., POON C.H., YOU R., HUANG C., Ng T.W., CHENG S.Y., Hung C.H.L., LEUNG Y., Yang X., Law A.C.K., Chiu K., Lau W.M., Mak J.C.W., Wong G.T.C., Lee S.M.Y. and Hoi M.P.M., Investigating mechanisms of risk factors for Alzheimer’s disease to learn how to prevent disease progression., International Alzheimer’s Disease Conference 2014. 24. |
| Researcher : O WS |
| List of Research Outputs |
| Liao S., Cheung K.H., O W.S. and Tang F., Adrenomedullin Increases the Short-Circuit Current in the Mouse Seminal Vesicle: Actions on Chloride Secretion, Biology of Reproduction. 2014. |
| Liao S., Cheung K.H., Cheung M.P.L., To J.Y.T., O W.S. and Tang F., Adrenomedullin increased the short-circuit current in the pig oviduct through chloride channels via the CGRP receptor: Mediation by cAMP and calcium ions but not by nitric oxide, Biology of Reproduction. 2013, 89(4): 99, 1-6. |
| Liao S., Cheung K.H., Cheung M.P.L., Wong P.F., O W.S. and Tang F., Adrenomedullin increases the short-circuit current in the rat prostate: Receptors, chloride channels, the effects of cAMP and calcium ions and implications on fluid secretion, Andrology. 2014, 2: 474-480. |
| O W.S., Li R.H.W., Liao S., Cheung A.N.Y., Ng E.H.Y., Yeung W.S.B., Ho J.C.M. and Tang F., Decreases in adrenomedullin expression and ciliary beat frequency in the nasal epithelium in tubal pregnancy, Fertility and Sterility. 2013, 100: 459-463.e1. |
| Sy M.H., Jiang J., O W.S., Deng Y. and Huen M.S.Y., The Ubiquitin Specific Protease USP34 promotes ubiquitin signaling at DNA double-strand breaks, Nucleic Acids Research. 2013, 41(18): 8572-80. |
| Researcher : PAN Y |
| List of Research Outputs |
| DAI Y., PAN Y. and Yip H.K.F., Combined Lithium And Noggin Treatment Regulates The Differentiation Of Neural Progenitor Cells In The Adult Spinal Cord And Promotes Functional Recovery After Chronic Spinal Cord Injury, 18th Research Postgraduate Sympsoium. 2013. |
| DAI Y., PAN Y., Cheung M.P.L. and Yip H.K.F., Inhibition Of Stat/smad Co-transcription Factor P300 Regulates Differentiation Of Adult Spinal Cord Neural Progenitors And Ameliorates Functional Recovery In Chronic Spinal Cord, Ninth International Symposium On Healthy Aging. 2014. |
| PAN Y., DAI Y. and Yip H.K.F., The Role Of GSK3-Beta Pathway In Oligodendroglial Progenitor Cell (OPC) Differentiation And Remyelination After Spinal Cord Injury (SCI), 18th Research Postgraduate Symposium, Li Ka Shing Faculty Of Medicine, HKU. 2013. |
| PAN Y., DAI Y., Cheung M.P.L. and Yip H.K.F., The Role Of GSK3-beta Pathway In Oligodendroglial Progenitor Cell Differentiation And Remyelination After Spinal Cord Injury, Ninth International Symposium On Healthy Aging. 2014. |
| Researcher : PANG PS |
| List of Research Outputs |
| PANG P.S., Epstein-Barr infection and viral gene expression in nasopharyngeal epithelial cells. 2013, 266 pages. |
| Researcher : PENG B |
| List of Research Outputs |
| PENG B., Xiao J., WANG K., So K.F., Tipoe G.L. and Lin B., Suppression of Microglial Activation Is Neuroprotective in a Mouse Model of Human Retinitis Pigmentosa. The Journal of Neuroscience, 2014, 34: 8139-8150. |
| WANG K., PENG B. and Lin B., Fractalkine receptor regulates microglial neurotoxicity in an experimental mouse glaucoma model, Glia. Wiley Periodicals, Inc., 2014, 62: 1943-1954. |
| Researcher : POON CH |
| List of Research Outputs |
| Chang R.C.C., Ho Y.S., WONG T.H.G., TSANG A.W.-.T., WUWONGSE S., POON C.H., YOU R., HUANG C., Ng T.W., CHENG S.Y., Hung C.H.L., LEUNG Y., Yang X., Law A.C.K., Chiu K., Lau W.M., Mak J.C.W., Wong G.T.C., Lee S.M.Y. and Hoi M.P.M., Investigating mechanisms of risk factors for Alzheimer’s disease to learn how to prevent disease progression., International Alzheimer’s Disease Conference 2014. 24. |
| POON C.H., Ho Y.S., Lok C.K.M., Leung M.C., Chiu K. and Chang R.C.C., Differential modulation of bacteria-induced sickness and inflammation by double stranded RNA-dependent protein kinase (PKR), Neuroscience 2013. Program # 277.01: Poster # EEE22. |
| POON C.H., Ho Y.S., Lok C.K.M., Chiu K. and Chang R.C.C., Effects of double stranded RNA-dependent protein kinase (PKR) on bacteria-mediated sickness and inflammation., The 9th International Symposium of Healthy Aging. 2014, 66. |
| Researcher : QIN D |
| List of Research Outputs |
| Su H., Yuan Q., QIN D., Yang X., Wong W.M., So K.F. and Wu W., Lithium enhances axonal regeneration in peripheral nerve by inhibiting glycogen synthase kinase 3b activation, BioMed Research International. 2014, Articile ID 658753: 7 pages. |
| Su H., Yuan Q., QIN D., Yang X., Wong W.M., So K.F. and Wu W., Ventral root re-implantation is better than peripheral nerve transplantation for motoneuron survival and regeneration after spinal root avulsion injury, BMC Surgery. 2013, 13: 21. |
| Researcher : Sang Y |
| List of Research Outputs |
| Sang Y., Liang Y., Behnke E.R.G., So K.F. and Cheung R.T.F., A self-assembling peptide nanofiber scaffold reduces acute brain injury and improves functional recovery in a hypertensive rat model of intracranial hemorrhage plus clot aspiration, The 5th World Conference of Intracerebral Hemorrhage & 20th Annual Scientific Meeting of the Hong Kong Neurosurgical Society, Hong Kong, China, 2-4 November 2013. |
| Sang Y., YANG X., Su H.X., Leung G.K.K., Wu W. and Cheung R.T.F., Local transplantation pf NPC in a rat model of intracerebral hemorrhage plus hematoma evacuation, Cell Symposia: Using Stem Cells to Model and Treat Human Disease, Los Angeles, U.S.A., 21-23 November 2013. |
| Sang Y., YANG X., Su H.X., Leung G.K.K., Wu W. and Cheung R.T.F., Transplantation of neural progenitor cells into the hematoma cavity improves functional outcome in a rat model of intracerebral hemorrhage, The 5th World Conference of Intracerebral Hemorrhage & 20th Annual Scientific Meeting of the Hong Kong Neurosurgical Society, Hong Kong, China, 2-4 November 2013. |
| Researcher : So K.F. |
| Project Title: | Study of gliogenesis and neurochemistry underlying psychomotor retardation induced by chronic stress and the therapeutic approach of motor training in reversing the adverse effects |
| Investigator(s): | So KF |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2013 |
| Completion Date: | 05/2015 |
| Project Title: | Minimizing neuropsychiatric side-effects of glucocorticoid therapy by antipsychotics and Chinese medicine |
| Investigator(s): | So KF, Lee TMC, Chang RCC, Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 01/2014 |
| List of Research Outputs |
| Researcher : So KF |
| Project Title: | Study of gliogenesis and neurochemistry underlying psychomotor retardation induced by chronic stress and the therapeutic approach of motor training in reversing the adverse effects |
| Investigator(s): | So KF |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2013 |
| Completion Date: | 05/2015 |
| Project Title: | Minimizing neuropsychiatric side-effects of glucocorticoid therapy by antipsychotics and Chinese medicine |
| Investigator(s): | So KF, Lee TMC, Chang RCC, Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 01/2014 |
| List of Research Outputs |
| Chan L.K., Chan O.O.C., Kwan A.L.H., So K.F., Tipoe G.L., Tsao G.S.W. and Wong P.W.L., Faculty Knowledge Exchange Award, The University of Hong Kong. 2014. |
| Chang R.C.C., Chiu K., Lok C.K.M., Turner R.S., Matsuoka Y. and So K.F., Examination of the retina in triple transgenic mice of Alzheimer's disease, Neuroscience 2013. Program # 710.13: Poster # G7. |
| Chang R.C.C., Wuwongse S., Wong S., Wong M.T.H., TSANG A.W.-.T., Zhang E., CHENG S.Y., Hung C.H.L., Lau W.M., Ho Y.S., So K.F. and Law A.C.K., Investigating biological mechanisms of corticosterone-induced neurodegeneration: Implication of how depression promotes cognitive impairment in Alzheimer's disease, Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 2013, 9 Issue 4 Supplement: 561-562. |
| Chiu K., Leung M.C., Leung I.Y.P., Lok C.K.M., Turner R., Matsuoka Y., So K.F. and Chang R.C.C., Morphometric analysis of the retina in a triple-transgenic model of Alzheimer's disease, Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 2013, 9, Issue 4, Supplement: 435. |
| Chu P.H.W., Li H., Chin M.P., So K.F. and Chan H.H.L., Effect of Lycium Barbarum (Wolfberry) polysaccharides on preserving retinal function after partial optic nerve transection, PLoS One. 2013, 8 Issue 12: e81339. |
| Fan Y., Yan C.P., Chen C., So K.F., Li P. and Qi L.W., Tissue-smashing based ultra-rapid extraction of chemical constituents in herbal medicines, Journal of Pharmaceutical and Biomedical Analysis. 2014, 95: 213-219. |
| GUO R., Lin B., PAN J., Liong E.C., Fung M.L., So K.F., Youdim M.B.H. and Tipoe G.L., M30 multi-functional drug reduces apoptosis, oxidative stress and inflammation in CCl4 -induced acute liver injury animal model, The Physiology Symposium 2014, P9, 6/2014, 2014. |
| GUO R., Lin B., PAN J., Liong E.C., Fung M.L., So K.F., Youdim M.B.H. and Tipoe G.L., M30 multi-functional drug reduces apoptosis, oxidative stress and inflammation in CCl4-induced acute liver injury animal model, The Ninth International Symposium on Healthy Aging – Aging with Confidence, P64, 3/2014. |
| Han Q., Feng J., Qu Y., Ding Y., Wang M., So K.F., Wu W. and Zhou L., Spinal cord maturation and locomotion in mice with an isolated cortex, Neuroscience. 2013, 253: 235-244. |
| He M., Pan H., Chang R.C.C., So K.F., Brecha N.C. and Pu M., Activaton of the Nrf2/HO-1 antioxidant pathway contributes to the protective effects of lycium barbarum polysaccharides in the rodent retina after ischemia-reperfusion-induced damage, PLos One. 2014, 9 Issue 1: e84800. |
| LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Cheung K.H. and Fung M.L., Lycium barbarum polysaccharides facilitate hippocampal neurogenesis induced by chronic intermittent hypoxia in rats, 18th Research Postgraduate Symposium, HKU, P5.12, 12/2013. |
| LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Chan Y.S., Cheung K.H. and Fung M.L., Mechanisms of Lycium barbarum polysaccharides against spatial memory deficits in rats exposed to chronic intermittent hpoxia, Proc. International Symposium on Physiomics p.75. 2013. |
| LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Cheung K.H. and Fung M.L., Mechanistic effects of Lycium barbarum polysaccharides against rat hippocampal injuries induced by chronic intermittent hypoxia, The 17th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, CP3, 11/2013. (Journal of the Hong Kong College of Cardiology, 21(2):69, CP3, 2013). 2013. |
| LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Cheung K.H., Chan Y.S. and Fung M.L., Neuroprotective mechanisms of Lycium barbarum polysaccharides against spatial memory impairment induced by chronic intermittent hypoxia, The Ninth International Symposium on Healthy Aging – Aging with Confidence, OP7, 3/2014. |
| Lau W.M., LEE C.D. and So K.F., Neurogenic hypothesis and psychiatric disorders, Chinese Science Bulletin. 2013, 58(26): 3188-3198. |
| Lee T.M.C., WONG M.L., Lau B.W.M., Lee J.C.D., Yau S.Y. and So K.F., Aerobic exercise interacts with neurotrophic factors to predict cognitive functioning in adolescents., Psychoneuroendocrinology. 2014, 39: 214-224. |
| Leung M.C.P., Yip K.K., Lam C.T., Lam K.S., Lau W., Yu W.L., Leung A.K.M., Leung A.K.M. and So K.F., Acupuncture improves cognitive function, A systematic review, Neural Regeneration Research. 2013, 8(18): 1673-1684. |
| Lin J., Lee H.M.E., Chan K.W., Chang W.C., Su W., Honer W.G., Khong P.L., Tse M.A., Chan C.L.W., So K.F. and Chen E.Y.H., The impacts of aerobic exercise and mind-body exercise (yoga) on neuro-cognition and clinical symptoms in early psychosis: a single-blind randomized controlled clinical trial , Schizophrenia Research. 2014, 153 (S1): 260. |
| SANG Y., Yang X., Ellis-Behnke R.G., So K.F. and Cheung R.T.F., A self-assembling peptide nanofiber scaffold reduces acute brain injury and improves functional recovery in a hypertensive rat model of intracerebral hemorrhage plus clot aspiration, The Conjoint Congress of the 5th World ICH Conference 2013 & 20th Annual Scientific Meeting of Hong Kong Neurosurgical Society. 2013, 106. |
| Sang L.Y.H., Liang Y., Li Y., Wong W.M., Tay D.K.C., So K.F., Ellis-Behnke R.G., Wu W. and Cheung R.T.F., A self-assembling nanomaterial reduces acute brain injury and enhances functional recovery in a rat model of intracerebral hemorrhage, Nanomedicine: Nanotechnology, Biology and Medicine. 2014, Epub on 2014-06-04. |
| Sang Y., Liang Y., Behnke E.R.G., So K.F. and Cheung R.T.F., A self-assembling peptide nanofiber scaffold reduces acute brain injury and improves functional recovery in a hypertensive rat model of intracranial hemorrhage plus clot aspiration, The 5th World Conference of Intracerebral Hemorrhage & 20th Annual Scientific Meeting of the Hong Kong Neurosurgical Society, Hong Kong, China, 2-4 November 2013. |
| Su H., Yuan Q., QIN D., Yang X., Wong W.M., So K.F. and Wu W., Lithium enhances axonal regeneration in peripheral nerve by inhibiting glycogen synthase kinase 3b activation, BioMed Research International. 2014, Articile ID 658753: 7 pages. |
| Su H., Yuan Q., QIN D., Yang X., Wong W.M., So K.F. and Wu W., Ventral root re-implantation is better than peripheral nerve transplantation for motoneuron survival and regeneration after spinal root avulsion injury, BMC Surgery. 2013, 13: 21. |
| Xiao J., Liong E.C., Chang R.C.C., Fung M.L., Xu A.M., So K.F. and Tipoe G.L., Lycium barbarum polysaccharides protect rat liver from non-alcoholic steatohepatitis-induced injury, Nutrition and Diabetes, Doi:10.1038/nutd.2013.22. 2013, 3,e81. |
| Xiao J., Wang J., Xing F., Han T., Jiao R., Liong E.C., Fung M.L., So K.F. and Tipoe G.L., Zeaxanthin dipalmitate therapeutically improves hepatic functions in an alcoholic fatty liver disease model through modulating MAPK pathway, PLOS ONE. 2014, 9(4): e95214. |
| Xiao J., Zhu Y., Liu Y., Tipoe G.L., Xing F. and So K.F., Lycium barbarum polysaccharide attenuates alcoholic cellular injury through TXNIP-NLRP3 inflammasome pathway, International Journal of Biological Macromolecules. 2014, 69: 73-78. |
| Xu M., Chen X., Gu Y., Peng T., Yang D., Chang R.C.C., So K.F., Liu K. and Shen J., Baicalin can scavenge peroxynitrite and ameliorate endogenous peroxynitrite-mediated neurotoxicity in cerebral ischemia-reperfusion injury, J Ethnopharmacol. 2013, 150(1): 116-24. |
| Yau S.Y. and So K.F., Adult neurogenesis and dendritic remodeling in hippocampal plasticity; Which one is more important?, Cell Transplantation. 2014, 23: 471-479. |
| Yau S.Y., Gil-Mohapel J., Christie B.R. and So K.F., Physical exercise-induced adult neurogenesis: A good strategy to prevent cognitive decline in neurodegenerative diseases?, BioMed Research International. 2014, Article ID 403120: 20 pages. |
| Yau S.Y., Li A., Zhang E., Christie B.R., Xu A., Lee T.M.C. and So K.F., Sustained running in rats administered corticosterone prevents the development of depressive behaviors and enhances hippocampal neurogenesis and synaptic plasticity without increasing neurotrophic factor levels, Cell Transplantaton. 2014, 23: 481-492. |
| Zeng H., Lee T.M.C., Walters J.H., So K.F., Sham P.C., Schottenfeld R.S., Marienfeld C. and Chawarski M.C., Impulsivity, cognitive function, and their relationship in heroin-dependent individuals, Journal of Clinical and Experimental Neuropsychology. 2013, 35(9): 897-905. |
| Zhou I.Y., Liang Y., Chan R.W., GAO P., Cheng J.S., Hu Y., So K.F. and Wu E.X., NeuroImage, Brain resting-state functional MRI connectivity: morphological foundation and plasticity.. 2014, 84: 1-10. |
| Zhou Y., Liang Y., Chan R.W., Gao P.P., Cheng J.S., Hu Y., So K.F. and Wu E.X., Brain resting-state functional MRI connectivity: Morphological foundation and plasticity, NeuroImage. 2013, 84: 1-10. |
| Researcher : Su H |
| List of Research Outputs |
| SANG Y., Yang X., Su H., Leung G.K.K., Wu W. and Cheung R.T.F., Transplantation of NPCs into the hematoma cavity improves functional outcome in a rat model of intracerebral hemorrhage, The Conjoint Congress of the 5th World ICH Conference 2013 & 20th Annual Scientific Meeting of Hong Kong Neurosurgical Society. 2013, 69-70. |
| Researcher : Sy MH |
| Project Title: | Regulation of Microcephalin (MCPH1) by the Herpes Simplex Virus Type 1 Regulatory Protein ICP0 |
| Investigator(s): | Sy MH, Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2013 |
| List of Research Outputs |
| Sy M.H., Jiang J., O W.S., Deng Y. and Huen M.S.Y., The Ubiquitin Specific Protease USP34 promotes ubiquitin signaling at DNA double-strand breaks, Nucleic Acids Research. 2013, 41(18): 8572-80. |
| Researcher : Sy SMH |
| Project Title: | Regulation of Microcephalin (MCPH1) by the Herpes Simplex Virus Type 1 Regulatory Protein ICP0 |
| Investigator(s): | Sy MH, Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2013 |
| List of Research Outputs |
| Researcher : TIRRELL L |
| List of Research Outputs |
| TIRRELL L., The role of RhoA GTPase activating protein DLC2 in painful diabetic neuropathy. 2013, 67 pages. |
| Researcher : TSANG AW-T |
| List of Research Outputs |
| Chang R.C.C., Wuwongse S., Wong S., Wong M.T.H., TSANG A.W.-.T., Zhang E., CHENG S.Y., Hung C.H.L., Lau W.M., Ho Y.S., So K.F. and Law A.C.K., Investigating biological mechanisms of corticosterone-induced neurodegeneration: Implication of how depression promotes cognitive impairment in Alzheimer's disease, Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 2013, 9 Issue 4 Supplement: 561-562. |
| Chang R.C.C., Ho Y.S., WONG T.H.G., TSANG A.W.-.T., WUWONGSE S., POON C.H., YOU R., HUANG C., Ng T.W., CHENG S.Y., Hung C.H.L., LEUNG Y., Yang X., Law A.C.K., Chiu K., Lau W.M., Mak J.C.W., Wong G.T.C., Lee S.M.Y. and Hoi M.P.M., Investigating mechanisms of risk factors for Alzheimer’s disease to learn how to prevent disease progression., International Alzheimer’s Disease Conference 2014. 24. |
| Chang R.C.C., TSANG A.W.-.T., Wong G.T.H., CHENG S.Y., Hung C.H.L., Ho Y.S. and Law A.C.K., Targeting depression to prevent dementia and Alzheimer's disease, International Conference on Pharmacology and Drug Development, Singapore 2013.. 2013, : 65. |
| TSANG A.W.-.T., Investigating the potential significance of tau protein in corticosterone-induced depression and neurodegeneraton: Implication in Alzheimer's disease. 2014, 119 pages. |
| WONG T.H.G., Hung C.H.L., TSANG A.W.-.T., Chang R.C.C. and Law A.C.K., Microtubule dysfunction in corticosterone and oligomeric beta-amyloid in vitro model and its effect on actin morphology., The 9th International Symposium of Healthy Aging. 2014, 50. |
| Researcher : Tay DKC |
| List of Research Outputs |
| Sang L.Y.H., Liang Y., Li Y., Wong W.M., Tay D.K.C., So K.F., Ellis-Behnke R.G., Wu W. and Cheung R.T.F., A self-assembling nanomaterial reduces acute brain injury and enhances functional recovery in a rat model of intracerebral hemorrhage, Nanomedicine: Nanotechnology, Biology and Medicine. 2014, Epub on 2014-06-04. |
| Researcher : Tipoe GL |
| Project Title: | The protective effects of Wolfberry (Lycium Barbarium Polysaccharide; LBP) in a clinically relevant orally fed non-alcoholic fatty liver disease (NAFLD) rat model |
| Investigator(s): | Tipoe GL, Ching YP, So KF |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2012 |
| Completion Date: | 05/2014 |
| Project Title: | Garlic derived S-allylmercaptocysteine (SAMC) reduces apoptosis in non-alcoholic fatty liver disease rat model through p53-dependent pathways |
| Investigator(s): | Tipoe GL |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2013 |
| Project Title: | 23rd Conference of the Asian Pacific Association for the Study of the Liver (APASL); Polysaccharides from Lycium barbarum attenuates hepatic steatosis, fibrosis and inflammation in non-alcoholic liver diseases (NAFLD) rat model |
| Investigator(s): | Tipoe GL |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2013 |
| Project Title: | Multifunctional M30 drug down-regulates carbon tetrachloride (CCl4) – induced hepatic oxidative stress, inflammation and apoptosis in vitro and in vivo models |
| Investigator(s): | Tipoe GL |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2014 |
| List of Research Outputs |
| Chan L.K., Chan O.O.C., Kwan A.L.H., So K.F., Tipoe G.L., Tsao G.S.W. and Wong P.W.L., Faculty Knowledge Exchange Award, The University of Hong Kong. 2014. |
| Chan T.K., Lee C.Y.Y., Yau S.K. and Tipoe G.L., Debate & Analysis Primary care in Asia: a call for compulsory vocational training, British Journal of General Practice. 2014, 64: 304-305. |
| Fung M.L., Tipoe G.L. and Leung P.S., Mechanisms of maladaptive responses of peripheral chemoreceptors to intermittent hypoxia in sleep-disordered breathing., Acta Physiologica Sinica. 2014, 66(1): 23-29. |
| GUO R., Lin B., PAN J., Liong E.C., Fung M.L., So K.F., Youdim M.B.H. and Tipoe G.L., M30 multi-functional drug reduces apoptosis, oxidative stress and inflammation in CCl4 -induced acute liver injury animal model, The Physiology Symposium 2014, P9, 6/2014, 2014. |
| GUO R., Lin B., PAN J., Liong E.C., Fung M.L., So K.F., Youdim M.B.H. and Tipoe G.L., M30 multi-functional drug reduces apoptosis, oxidative stress and inflammation in CCl4-induced acute liver injury animal model, The Ninth International Symposium on Healthy Aging – Aging with Confidence, P64, 3/2014. |
| Hung M.W., Kravtsov G.M., Lau C.F., Poon A.M.S., Tipoe G.L. and Fung M.L., Melatonin ameliorates endothelial dysfunction, vascular inflammation, and systemic hypertension in rats with chronic intermittent hypoxia, Journal of Pineal Research. 2013, 55: 247-256. |
| LAM C.S., Liu Y.Y., Tipoe G.L. and Fung M.L., Induction of depressive-like behavior in a rat model of obstructive sleep apnea, The Physiology Symposium 2014, N61, 6/2014. |
| LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Cheung K.H. and Fung M.L., Lycium barbarum polysaccharides facilitate hippocampal neurogenesis induced by chronic intermittent hypoxia in rats, 18th Research Postgraduate Symposium, HKU, P5.12, 12/2013. |
| LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Chan Y.S., Cheung K.H. and Fung M.L., Mechanisms of Lycium barbarum polysaccharides against spatial memory deficits in rats exposed to chronic intermittent hpoxia, Proc. International Symposium on Physiomics p.75. 2013. |
| LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Cheung K.H. and Fung M.L., Mechanistic effects of Lycium barbarum polysaccharides against rat hippocampal injuries induced by chronic intermittent hypoxia, The 17th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, CP3, 11/2013. (Journal of the Hong Kong College of Cardiology, 21(2):69, CP3, 2013). 2013. |
| LAM C.S., Tipoe G.L., Chang R.C.C., So K.F., Cheung K.H., Chan Y.S. and Fung M.L., Neuroprotective mechanisms of Lycium barbarum polysaccharides against spatial memory impairment induced by chronic intermittent hypoxia, The Ninth International Symposium on Healthy Aging – Aging with Confidence, OP7, 3/2014. |
| Lam S.S.Y., liu Y., Ng K.M., Liong E.C., Tipoe G.L., Leung P.S. and Fung M.L., Upregulation of a local renin-angiotensin system in the rat carotid body during chronic intermittent hypoxia, Experimental Physiology. 2014, 99: 220-231. |
| PAN J., GUO R., Liong E.C., Tipoe G.L. and Fung M.L., Intermittent hypoxia exacerbates lipid accumulation, inflammation and apoptosis via NADPH oxidase in a cell model of non-alcoholic fatty liver disease, The Physiology Symposium 2014, P27, 6/2014. |
| PAN J., GUO R., Liong E.C., Tipoe G.L. and Fung M.L., Oxidative stress induced by chronic intermittent hypoxia aggravates hepatic inflammation in nonalcoholic fatty liver disease (NAFLD), 18th Research Postgraduate Symposium, HKU P5.17, 12/2013. |
| PAN J., GUO R., Liong E.C., Tipoe G.L. and Fung M.L., Oxidative stress induced by intermittent hypoxia aggravates lipid accumulation and autophagy in a cell model of nonalcoholic fatty liver disease (NAFLD), The Ninth International Symposium on Healthy Aging – Aging with Confidence, P35, 3/2014. |
| PAN J., GUO R., Liong E.C., Tipoe G.L. and Fung M.L., Oxidative stress induced by intermittent hypoxia exacerbates lipid accumulation and inflammation in HepG2 cells. 2013 International Symposium on Physiomics &Taiwan, Hong Kong Physiology Symposium. Taipei, Taiwan. 2013. |
| PAN J., GUO R., Liong E.C., Tipoe G.L. and Fung M.L., Oxidative stress induced by intermittent hypoxia exacerbates lipid accumulation and inflammation in a cell model of non-alcoholic steatohepatitis. The 17th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, OP3, 11/2013, Journal of the Hong Kong College of Cardiology. 2013, 21(2):65. |
| PENG B., Xiao J., WANG K., So K.F., Tipoe G.L. and Lin B., Suppression of Microglial Activation Is Neuroprotective in a Mouse Model of Human Retinitis Pigmentosa. The Journal of Neuroscience, 2014, 34: 8139-8150. |
| WU F., GUO R., Tipoe G.L. and Fung M.L., Exercise attenuates left ventricular hypertrophy induced by high fat diet in rats, 18th Research Postgraduate Symposium, HKU, P5.25, 12/2013.. 2013. |
| WU F., GUO R., PAN J., Tipoe G.L. and Fung M.L., Involvement of autophagy in the effect of exercise on left ventricular hypertrophy induced by high fat diet in rats. The 17th Annual Scientific Meeting of the Institute of Cardiovascular Science and Medicine, CP5, Journal of the Hong Kong College of Cardiology. 2013, 21(2):70. |
| WU F., GUO R., PAN J., Tipoe G.L. and Fung M.L., Potential role of autophagy in the effect of exercise on left ventricular hypertrophy induced by high fat diet in rats. 2013 International Symposium on Physiomics &Taiwan , Hong Kong Physiology Symposium. Taipei, Taiwan,. 2013. |
| Xiao J., Ho M.C.T., Liong E.C., Nanji A.A., Leung T.M., Lau T.Y.H., Fung M.L. and Tipoe G.L., Epigallocatechin gallate attenuates fibrosis, oxidative stress, and inflammation in non-alcoholic fatty liver disease rat model through TGF/SMAD, PI3 K/Akt/FoxO1, and NF-kappa B pathways, European Journal of Nutrition. 2014, 53(1): 187-199. |
| Xiao J., Zhu Y.I.N.G.H.U.I., Liu Y.I.N.G.X.I.A., Tipoe G.L., Xing F.E.I.Y.U.E. and So K.F., Lycium Barbarum Polysaccharide Attenuates Alcoholic Cellular Injury Through TXNIP=NLRP3 Inflammasome Pathway. International Journal of Biological Macromolecules, 2014, 69: 73-78. |
| Xiao J., Liong E.C., Chang R.C.C., Fung M.L., Xu A.M., So K.F. and Tipoe G.L., Lycium barbarum polysaccharides protect rat liver from non-alcoholic steatohepatitis-induced injury, Nutrition and Diabetes, Doi:10.1038/nutd.2013.22. 2013, 3,e81. |
| Xiao J., Wang J., Xing F., Han T., Jiao R., Liong E.C., Fung M.L., So K.F. and Tipoe G.L., Zeaxanthin dipalmitate therapeutically improves hepatic functions in an alcoholic fatty liver disease model through modulating MAPK pathway, PLOS ONE. 2014, 9(4): e95214. |
| Xiao J., Zhu Y., Liu Y., Tipoe G.L., Xing F. and So K.F., Lycium barbarum polysaccharide attenuates alcoholic cellular injury through TXNIP-NLRP3 inflammasome pathway, International Journal of Biological Macromolecules. 2014, 69: 73-78. |
| Researcher : Tsang C.M. |
| Project Title: | The biological significance of TGF-β1 in sensitizing the nasopharyngeal epithelial cells to EBV infection |
| Investigator(s): | Tsang CM, Yip YL, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2013 |
| Project Title: | The protective role of Epstein-Barr virus infection towards starvation-induced apoptosis |
| Investigator(s): | Tsang CM, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2014 |
| List of Research Outputs |
| Researcher : Tsang CM |
| Project Title: | The biological significance of TGF-β1 in sensitizing the nasopharyngeal epithelial cells to EBV infection |
| Investigator(s): | Tsang CM, Yip YL, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2013 |
| Project Title: | The protective role of Epstein-Barr virus infection towards starvation-induced apoptosis |
| Investigator(s): | Tsang CM, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Health and Medical Research Fund - Full Grant |
| Start Date: | 04/2014 |
| List of Research Outputs |
| Tsang C.M., Cheung Y.C., Lui W.Y.V., Yip Y.L., Zhang G., LIN W., Cheung K.C.P., Feng Y. and Tsao G.S.W., Berberine suppresses tumorigenicity and growth of nasopharyngeal carcinoma cells by inhibiting STAT3 activation induced by tumor associated fibroblasts, BMC Cancer. 2013, 13: 619. |
| Tsao G.S.W., Yip Y.L., Tsang C.M., Pang P.S., LAU M.Y., Zhang G. and Lo K.W., Etiological factors of nasopharyngeal carcinoma, Oral Oncology. 2014, 50: 330-8. |
| Yip Y.L., Pang P.S., Deng W., Tsang C.M., Zeng M., Hau P.M., Man C., Jin Y., Yuen A.P. and Tsao G.S.W., Efficient immortalization of primary nasopharyngeal epithelial cells for EBV infection study., PLoS One. 2013, 8: e78395. |
| Researcher : Tsao G.S.W. |
| Project Title: | Cancer |
| Investigator(s): | Tsao GSW, Poon RTP |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding for Strategic Research Theme |
| Start Date: | 11/2008 |
| Project Title: | The role of TGF-beta in EBV infection and pathogenesis of nasopharyngeal carcinoma |
| Investigator(s): | Tsao GSW, Lan HY |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2009 |
| Project Title: | NF-kB activation in the immortalization of nasopharyngeal epithelial cells |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2010 |
| Project Title: | The role of cyclin D1 in the persistence of Epstein-Barr virus (EBV) infection in premalignant nasopharyngeal epithelial cells. |
| Investigator(s): | Tsao GSW, Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2011 |
| Project Title: | The role of IL6 on EBV-infected nasopharyngeal epithelial cells |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2012 |
| Completion Date: | 12/2013 |
| Project Title: | The role of ATM signaling in the lytic replication of Epstein-Barr virus in infected nasopharyngeal epithelial cells |
| Investigator(s): | Tsao GSW, Chiang AKS, Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2013 |
| Project Title: | Functional interaction of EBV-encoded BZLF1 with the DNA damage repair proteins |
| Investigator(s): | Tsao GSW, Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2013 |
| Project Title: | Dynamics of EBV episome maintenance in infected nasopharyngeal epithelial cells |
| Investigator(s): | Tsao GSW, Chen H, Deng W |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Project Title: | Systematic Development of Molecular Targets for Nasopharyngeal Carcinoma |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Theme-based Research Scheme |
| Start Date: | 01/2014 |
| Project Title: | Advances in Live Cell and Intravital Imaging in Biomedicine |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Croucher Foundation - Conference / Seminars |
| Start Date: | 03/2014 |
| Project Title: | American Association for Cancer Research Annual Meeting 2014; The role of ATM in lytic infection of EBV in nasopharyngeal epithelial cells. |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2014 |
| Completion Date: | 04/2014 |
| Project Title: | Live cell imaging of invasion by EBV-infected nasopharyngeal epithelial cells. |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2014 |
| List of Research Outputs |
| Researcher : Tsao GSW |
| Project Title: | Cancer |
| Investigator(s): | Tsao GSW, Poon RTP |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding for Strategic Research Theme |
| Start Date: | 11/2008 |
| Project Title: | The role of TGF-beta in EBV infection and pathogenesis of nasopharyngeal carcinoma |
| Investigator(s): | Tsao GSW, Lan HY |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2009 |
| Project Title: | NF-kB activation in the immortalization of nasopharyngeal epithelial cells |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 11/2010 |
| Project Title: | The role of cyclin D1 in the persistence of Epstein-Barr virus (EBV) infection in premalignant nasopharyngeal epithelial cells. |
| Investigator(s): | Tsao GSW, Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 10/2011 |
| Project Title: | The role of IL6 on EBV-infected nasopharyngeal epithelial cells |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2012 |
| Completion Date: | 12/2013 |
| Project Title: | The role of ATM signaling in the lytic replication of Epstein-Barr virus in infected nasopharyngeal epithelial cells |
| Investigator(s): | Tsao GSW, Chiang AKS, Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2013 |
| Project Title: | Functional interaction of EBV-encoded BZLF1 with the DNA damage repair proteins |
| Investigator(s): | Tsao GSW, Huen MSY |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 05/2013 |
| Project Title: | Dynamics of EBV episome maintenance in infected nasopharyngeal epithelial cells |
| Investigator(s): | Tsao GSW, Chen H, Deng W |
| Department: | Anatomy |
| Source(s) of Funding: | General Research Fund (GRF) |
| Start Date: | 01/2014 |
| Project Title: | Systematic Development of Molecular Targets for Nasopharyngeal Carcinoma |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Theme-based Research Scheme |
| Start Date: | 01/2014 |
| Project Title: | Advances in Live Cell and Intravital Imaging in Biomedicine |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Croucher Foundation - Conference / Seminars |
| Start Date: | 03/2014 |
| Project Title: | American Association for Cancer Research Annual Meeting 2014; The role of ATM in lytic infection of EBV in nasopharyngeal epithelial cells. |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 04/2014 |
| Completion Date: | 04/2014 |
| Project Title: | Live cell imaging of invasion by EBV-infected nasopharyngeal epithelial cells. |
| Investigator(s): | Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2014 |
| List of Research Outputs |
| CHEN C., ZHANG Y., ZHANG Y., Li J., Tsao G.S.W. and Zhang M., Superior Antitumor Activity of a Novel Bispecific Antibody Cotargeting Human Epidermal Growth Factor Receptor 2 and Type I Insulin-like Growth Factor Receptor, Molecular Cancer Therapeutics. 2013, 13: 90-100. |
| Chan L.K., Chan O.O.C., Kwan A.L.H., So K.F., Tipoe G.L., Tsao G.S.W. and Wong P.W.L., Faculty Knowledge Exchange Award, The University of Hong Kong. 2014. |
| Chan M.C.W., Chan W.Y., Tsao G.S.W. and Peiris J.S.M., Replication and pathogenesis of avian influenza A (H5N1) virus infection in polarised human bronchial and alveolar epithelium, Hong Kong Medical Journal. 2013, 19 Supp 4: 24-8. |
| Cheung A., Xu W., Li B., Tsao G.S.W. and Chan K.W., Id1 induced IGF2 promotes bidirectional interaction between oesophageal cancer cells and fibroblasts in the tumour microenvironment, European Cancer Congress, Amsterdam, 27 September - 1 October 2013, Holland. 2013, 392. |
| Cheung A.K.L., Ip J.C.Y., Lung H.L., Wu J.Z., Tsao G.S.W. and Lung M.L., Polo-like Kinase Inhibitor Ro5203280 Has Potent Antitumor Activity in Nasopharyngeal Carcinoma, Molecular cancer therapeutics. 2013. |
| Cheung C.C., Chung G.T., Lun S.W., To K.F., Choy K.W., Lau K.M., Siu S.P., Guan X., Ngan R.K., Yip T.T., Busson P., Tsao G.S.W. and Lo K.W., miR-31 is consistently inactivated in EBV-associated nasopharyngeal carcinoma and contributes to its tumorigenesis, Molecular Cancer . 2014, 13(1):184: 184. |
| Chow J.P., Man W.Y., Mao M., Chen H., Cheung M.F.F., Nicholls J.M., Tsao G.S.W., Lung M.L. and Poon R.Y., Poly(ADP-ribose) polymerase 1 is overexpressed in nasopharyngeal carcinoma and its inhibition enhances radiotherapy, Molecular Cancer Therapeutics. 2013, 12(11): 2517-28. |
| HAN L., Li B., Tsao G.S.W. and Cheung A., Roles of miR-338-5p in downregulating Id-1 and inhibiting chemoresistance and cancer cell invasion, 20th Hong Kong International Cancer congress, November 14-15, 2013, Hong Kong. 2013, No. A21. |
| Ho Y., Tsao G.S.W., Zeng M.S. and Lui V.W., STAT3 as a therapeutic target for Epstein-Barr virus (EBV): associated nasopharyngeal carcinoma, Cancer Lett. 2013, Apr 28;330(2):: 141-9. |
| Ip K.M., Yung S.S.Y., Chan D.T.M., Tsao G.S.W. and Wong A.S.T., p70 S6 kinase is a regulator of ovarian cancer metastasis via crosstalk between P-cadherin-beta1-integrin signaling axes., The 20th Hong Kong International Cancer Congress. 2013. |
| Ip K.M., Yung S.S.Y., Chan D.T.M., Tsao G.S.W. and Wong A.S.T., p70 S6 kinase promotes a critical step in ovarian cancer metastasis by modulating tumor-mesothelial cell adhesion through P-cadherin-beta1-integrin crosstalk., The European Cancer Congress 2013. |
| LAM S.N., Yung S.S.Y., Chan D.T.M., Tsao G.S.W. and Wong A.S.T., MicroRNA-145, a p70 S6 kinase-activated microRNA, regulates N-cadherin expression and epithelial-mesenchymal transition, 17thECCO - 28thESMO - 32ndESTRO European Cancer Congress, Amsterdam, Netherlands. 2013. |
| LEUNG O.N., Deng W., Ye T., Ngan H.Y.S., Tsao G.S.W., Cheung A.N.Y., Pang R.T.K. and Yeung W.S.B., miR-135a leads to cervical cancer cell transformation through regulation of β-catenin via a SIAH1-dependent ubiquitin proteosomal pathway, Carcinogenesis. 2014. |
| LIU J., Li B., Yang J., Huen M.S.Y., Tsao G.S.W. and Cheung A., FBX031 negatively regulates p38 MAPK by promoting ubiquitination and degradation of MAP kinase kinase 6, 20th Hong Kong International Cancer Congress, November 14-15, 2013, Hong Kong. 2013, No. A16. |
| Lei T., Yuen K.S., Tsao G.S.W., Chen H., Kok K.H. and Jin D., Perturbation of biogenesis and targeting of Epstein-Barr virus-encoded miR-BART3 microRNA by adenosine-to-inosine editing, Journal of General Virology. 2013, 94: 2739-2744. |
| Lei T., YUEN K.S., Xu R., Tsao G.S.W., Chen H., Li M., Kok K.H. and Jin D., Targeting of DICE1 tumor suppressor by Epstein-Barr virus-encoded miR-BART3* microRNA in nasopharyngeal carcinoma, International Journal of Cancer. 2013, 133: 79-87. |
| Li B., Tsao G.S.W., Chan K.W., Ludwig D.L., Novosyadlyy R., Li Y.Y., He Q.Y. and Cheung A., Id1-induced IGF-II and its autocrine/endocrine promotion of esophageal cancer progression and chemoresistance-implications for IGF-II and IGF-IR-targeted therapy, Clinical Cancer Research. 2014, 2651-2662. |
| Li B., Tsao G.S.W., Chan K.W. and Cheung A., Id1/IGF2/IGF1R/P13K/AKT signaling cascade as functional markers and therapeutic targets in esophageal cancer, European Journal of Cancer. 2013, 49 Suppl. 4: S23 MC13-0039. |
| Liu J., HAN L., Li B., Yang J., Huen M.S.Y., Pan X., Tsao G.S.W. and Cheung A., F-box only protein 31 (FBX031) negatively regulates p38 mitogen-activated protein kinase (MAPK) signaling by mediating lysine 48-linked ubiquitination and degradation of mitogen-activated protein kinase kinase 6 (MKK6), Journal of Biological Chemistrry. 2014, 289: 21508-21518. |
| Lo M.C., YIP T.C., Ngan K.C., Cheng W.W., Law C.K., Chan P.S., Chan K.C., Wong K.C., Wong N.S., Lo K.W., Ng W.T., Lee A.W.M., Tsao G.S.W., Kwong D.L.W., Lung M.L. and Mak N.K., Role of MIF/CXCL8/CXCR2 signaling in the growth of nasopharyngeal carcinoma tumor spheres, Cancer Letters. 2013, 335(1): 81-92. |
| QIN J., LI J., WANG P., Wong N.S., Wong M.P., Xia Z., Tsao G.S.W., Zhang M.Q. and Wang J.J., ProteoMirExpress: inferring microRNA-centered regulatory networks from high throughput proteomic and mRNA expression data, Molecular & Cellular Proteomics. 2013, 12: 3379-3387. |
| Qin J., LI J., Wang P., Wong N.S., Wong M.P., Xia Z., Tsao G.S.W., Zhang M.Q. and Wang J.J., ProteoMirExpress: Inferring MicroRNA and Protein-centered Regulatory Networks from High-throughput Proteomic and mRNA Expression Data, Molecular & Cellular Proteomics. 2013, 12: 3379-3387. |
| Szeto C.Y.Y., Lin C., Choi S.C., Yip T.T., Ngan R.K., Tsao G.S.W. and Lung M.L., Integrated mRNA and microRNA transcriptome sequencing characterizes sequence variants and mRNA – microRNA regulatory network in nasopharyngeal carcinoma model systems. , FEBS Open Biology. 2014, 10: 1016. |
| TAN H.Y., Wang N., Tsao G.S.W., Zhang Z. and Feng Y., Suppression of Vascular Endothelial Growth Factor via Inactivation of Eukaryotic Elongation Factor 2 by Alkaloids in Coptidis rhizoma in Hepatocellular Carcinoma, Integrative Cancer Therapies. 2013. |
| Tsang C.M., Cheung Y.C., Lui W.Y.V., Yip Y.L., Zhang G., LIN W., Cheung K.C.P., Feng Y. and Tsao G.S.W., Berberine suppresses tumorigenicity and growth of nasopharyngeal carcinoma cells by inhibiting STAT3 activation induced by tumor associated fibroblasts, BMC Cancer. 2013, 13: 619. |
| Tsao G.S.W., Epstein-barr Virus Infection In Premalignant Nasopharyngeal Epithelial Cells, The 6th International Symposium on Nasopharyngeal Carcinoma, June 20- 22, 2013, Istanbul, Turkey. 2013. |
| Tsao G.S.W., Yip Y.L., Tsang C.M., Pang P.S., LAU M.Y., Zhang G. and Lo K.W., Etiological factors of nasopharyngeal carcinoma, Oral Oncology. 2014, 50: 330-8. |
| Wang N., ZHU M., Wang X., TAN H.Y., Tsao G.S.W. and Feng Y., Berberine-induced tumor suppressor p53 up-regulation gets involved in the regulatory network of MIR-23a in hepatocellular carcinoma, Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. 2014. |
| Wang N., Zhu M., Tsao G.S.W., Man K., Zhang Z. and Feng Y., MiR-23a-mediated inhibition of topoisomerase 1 expression potentiates cell response to etoposide in human hepatocellular carcinoma, Molecular Cancer. Elsevier, 2013, 12(1):119.: doi: 10.1186/1476-4598-12-119. |
| Wang X., Ng R.K., Ming X., Zhang W., Chen L., Chu A.C.Y., Pang R.W.C., Lo C.M., Tsao G.S.W., Liu X., Poon R.T.P. and Fan S.T., Epigenetic regulation of pluripotent genes mediates stem cell features in human hepatocellular carcinoma and cancer cell lines, PLoS One. 2013, 8(9): e72435. |
| XU W., Li B., Tsao G.S.W., Chan K.W. and Cheung A., Mechanistic study of the interactions between Id1-overexpressing esophageal cancer cells and fibroblasts in the tumor microenvironment, 2013 NCRI Cancer Conference, 3-6 November 2013, Liverpool, U. K.. 2013, A191. |
| XU W., Li B., Tsao G.S.W., Chan K.W. and Cheung A., Suppression of angiogenesis and esophageal cancer progression by selective targeting of hematopoietic and endothelial progenitor cells, 18th International Vascular Biology Meeting, April 14-17, 2014, Kyoto, Japan. 2014, P-513. |
| Yip Y.L., Pang P.S., Deng W., Tsang C.M., Zeng M., Hau P.M., Man C., Jin Y., Yuen A.P. and Tsao G.S.W., Efficient immortalization of primary nasopharyngeal epithelial cells for EBV infection study., PLoS One. 2013, 8: e78395. |
| Researcher : Tse EYT |
| Project Title: | Characterization of NIMA (never in mitosis gene a)-related kinase 2 (Nek2) in Hepatocellular Carcinoma (HCC) |
| Investigator(s): | Tse EYT, Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2013 |
| Project Title: | The 17th ECCO – 38th ESMO – 32nd ESTRO European Cancer Congress; Functional characterization of NIMA (never in mitosis gene a)-related kinase 2 in hepatocellular carcinoma |
| Investigator(s): | Tse EYT |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 09/2013 |
| Completion Date: | 10/2013 |
| List of Research Outputs |
| Tse E.Y.T. and Ching Y.P., Functional characterization of NIMA (never in mitosis gene a)-related kinase 2 in Hepatocellular Carcinoma, The 17th ECCO-38th ESMO-32nd ESTRO European Cancer Congress. 2013. |
| Researcher : WANG K |
| List of Research Outputs |
| PENG B., Xiao J., WANG K., So K.F., Tipoe G.L. and Lin B., Suppression of Microglial Activation Is Neuroprotective in a Mouse Model of Human Retinitis Pigmentosa. The Journal of Neuroscience, 2014, 34: 8139-8150. |
| WANG K., PENG B. and Lin B., Fractalkine receptor regulates microglial neurotoxicity in an experimental mouse glaucoma model, Glia. Wiley Periodicals, Inc., 2014, 62: 1943-1954. |
| Researcher : WONG YN |
| List of Research Outputs |
| Wong L.L.Y., Lam P.Y., WONG Y.N., Lai W.L., Liu M.H.F., Yeung L.L. and Ching Y.P., IPA-3 inhibits the growth of liver cancer cells by suppressing PAK1 and NF-kB activation, PLOS ONE. 2013, 8(7), pp: e68843. |
| Researcher : WU Y |
| List of Research Outputs |
| WU Y., Chan L.K. and Fielding R., Award of Merit, Frontiers in Medical and Health Sciences Education, Li Ka Shing Faculty of Medicine, The University of Hong Kong. 2013. |
| WU Y., Chan L.K. and Fielding R., The effects of Chinese medical terms on Hong Kong people's comprehension of medical information, Frontiers in Medical and Health Sciences Education, 6-7 December 2013, Hong Kong. Received Award of Merit.. 2013. |
| Researcher : Wang X |
| Project Title: | The role fo MAD2 in overcoming cisplatin resistance in testicular germ cell tumors |
| Investigator(s): | Wang X, Jin D |
| Department: | Anatomy |
| Source(s) of Funding: | Lance Armstrong Foundation - General Award |
| Start Date: | 10/2003 |
| Project Title: | Significance of MAD2 expression to chromosomal instability in prostate cancer |
| Investigator(s): | Wang X |
| Department: | Anatomy |
| Source(s) of Funding: | Association for International Cancer Research - General Award |
| Start Date: | 04/2004 |
| Project Title: | Molecular mechanisms involved in the suppressive effects of garlic derivatives on cell growth and motility in prostate cancer cells |
| Investigator(s): | Wang X |
| Department: | Anatomy |
| Source(s) of Funding: | American Institute for Cancer Research (AICR) - General Award |
| Start Date: | 08/2005 |
| Researcher : Wang X |
| Project Title: | Angio-(1-7) and ACE2 during normal and hypertensive pregnancy |
| Investigator(s): | Wang X, Ellis-Behnke RG |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 12/2008 |
| Researcher : Wong LLY |
| Project Title: | An investigation on p21-activated protein kinase 1 inhibitor, IPA-3, in hepatocellular carcinoma |
| Investigator(s): | Wong LLY, Ching YP |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2012 |
| Completion Date: | 08/2013 |
| List of Research Outputs |
| Wong L.L.Y., Lam P.Y., WONG Y.N., Lai W.L., Liu M.H.F., Yeung L.L. and Ching Y.P., IPA-3 inhibits the growth of liver cancer cells by suppressing PAK1 and NF-kB activation, PLOS ONE. 2013, 8(7), pp: e68843. |
| Researcher : Wong PWL |
| List of Research Outputs |
| Chan L.K., Chan O.O.C., Kwan A.L.H., So K.F., Tipoe G.L., Tsao G.S.W. and Wong P.W.L., Faculty Knowledge Exchange Award, The University of Hong Kong. 2014. |
| Researcher : Wong WM |
| List of Research Outputs |
| LU Y., HAO B., Graeff R.M., Wong W.M., Wu W. and Yue J., Two Pore Channel 2 (TPC2) Inhibits Autophagosomal-Lysosomal Fusion by Alkalinizing Lysosomal pH, J Biol Chem.. 2013, 288(33): 24247-63. |
| Sang L.Y.H., Liang Y., Li Y., Wong W.M., Tay D.K.C., So K.F., Ellis-Behnke R.G., Wu W. and Cheung R.T.F., A self-assembling nanomaterial reduces acute brain injury and enhances functional recovery in a rat model of intracerebral hemorrhage, Nanomedicine: Nanotechnology, Biology and Medicine. 2014, Epub on 2014-06-04. |
| Su H., Yuan Q., QIN D., Yang X., Wong W.M., So K.F. and Wu W., Lithium enhances axonal regeneration in peripheral nerve by inhibiting glycogen synthase kinase 3b activation, BioMed Research International. 2014, Articile ID 658753: 7 pages. |
| Su H., Yuan Q., QIN D., Yang X., Wong W.M., So K.F. and Wu W., Ventral root re-implantation is better than peripheral nerve transplantation for motoneuron survival and regeneration after spinal root avulsion injury, BMC Surgery. 2013, 13: 21. |
| Researcher : Wong YC |
| Project Title: | Induction of breast carcinogenesis by a combination of androgens and oestrogens |
| Investigator(s): | Wong YC, Xie B |
| Department: | Anatomy |
| Source(s) of Funding: | Other Funding Scheme |
| Start Date: | 07/1997 |
| Project Title: | The Beijing, Hong Kong and UK Collaborative Study on the Molecular Genetic Basis of Differential Susceptibility of Prostate Cancer Between Chinese and Caucasian |
| Investigator(s): | Wong YC, Wang X, Ho KMT |
| Department: | Anatomy |
| Source(s) of Funding: | The University of Hong Kong Foundation Seed Grant |
| Start Date: | 07/2003 |
| List of Research Outputs |
| Kwan P.S., Lau C.C., Chiu Y.T., Wong Y.C. and Ling M.T., Daxx regulates mitotic progression and prostate cancer predisposition, Carcinogenesis. 2013, 34: 750-759. |
| Researcher : Wu W |
| Project Title: | Effects of chondroitinase ABC and lithium chloride on neuronal survival and regeneration after spinal cord injury |
| Investigator(s): | Wu W, Yick LW, So KF |
| Department: | Anatomy |
| Source(s) of Funding: | Matching Fund for National Key Basic Research Development Scheme (973 Projects) |
| Start Date: | 11/2003 |
| Project Title: | Research Output Prize |
| Investigator(s): | Wu W, Su H, Wong WM, So KF, Wu EX |
| Department: | Anatomy |
| Source(s) of Funding: | Research Output Prize (in Faculty) |
| Start Date: | 10/2008 |
| Project Title: | Influence of corticospinal tract on the survival and regeneration of spinal motor neurons after axonal injury |
| Investigator(s): | Wu W |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 06/2012 |
| Completion Date: | 05/2014 |
| Project Title: | Fabrication of a bioactive nanofibrous conduit for functional recovery of spinal cord injury |
| Investigator(s): | Wu W |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2014 |
| Project Title: | Symposium for Chinese Neuroscience Worldwide 2014; Survival and regeneration of motor neurons after axonal injury |
| Investigator(s): | Wu W |
| Department: | Anatomy |
| Source(s) of Funding: | URC/CRCG - Conference Support for Teaching Staff |
| Start Date: | 06/2014 |
| List of Research Outputs |
| Han Q., Feng J., Qu Y., Ding Y., Wang M., So K.F., Wu W. and Zhou L., Spinal cord maturation and locomotion in mice with an isolated cortex, Neuroscience. 2013, 253: 235-244. |
| LU Y., HAO B., Graeff R.M., Wong W.M., Wu W. and Yue J., Two Pore Channel 2 (TPC2) Inhibits Autophagosomal-Lysosomal Fusion by Alkalinizing Lysosomal pH, J Biol Chem.. 2013, 288(33): 24247-63. |
| SANG Y., Yang X., Su H., Leung G.K.K., Wu W. and Cheung R.T.F., Transplantation of NPCs into the hematoma cavity improves functional outcome in a rat model of intracerebral hemorrhage, The Conjoint Congress of the 5th World ICH Conference 2013 & 20th Annual Scientific Meeting of Hong Kong Neurosurgical Society. 2013, 69-70. |
| Sang L.Y.H., Liang Y., Li Y., Wong W.M., Tay D.K.C., So K.F., Ellis-Behnke R.G., Wu W. and Cheung R.T.F., A self-assembling nanomaterial reduces acute brain injury and enhances functional recovery in a rat model of intracerebral hemorrhage, Nanomedicine: Nanotechnology, Biology and Medicine. 2014, Epub on 2014-06-04. |
| Sang Y., YANG X., Su H.X., Leung G.K.K., Wu W. and Cheung R.T.F., Local transplantation pf NPC in a rat model of intracerebral hemorrhage plus hematoma evacuation, Cell Symposia: Using Stem Cells to Model and Treat Human Disease, Los Angeles, U.S.A., 21-23 November 2013. |
| Sang Y., YANG X., Su H.X., Leung G.K.K., Wu W. and Cheung R.T.F., Transplantation of neural progenitor cells into the hematoma cavity improves functional outcome in a rat model of intracerebral hemorrhage, The 5th World Conference of Intracerebral Hemorrhage & 20th Annual Scientific Meeting of the Hong Kong Neurosurgical Society, Hong Kong, China, 2-4 November 2013. |
| Su H., Yuan Q., QIN D., Yang X., Wong W.M., So K.F. and Wu W., Lithium enhances axonal regeneration in peripheral nerve by inhibiting glycogen synthase kinase 3b activation, BioMed Research International. 2014, Articile ID 658753: 7 pages. |
| Su H., Yuan Q., QIN D., Yang X., Wong W.M., So K.F. and Wu W., Ventral root re-implantation is better than peripheral nerve transplantation for motoneuron survival and regeneration after spinal root avulsion injury, BMC Surgery. 2013, 13: 21. |
| Un K.C., Wang Y., Wu W. and Leung G.K.K., Systemic progesterone for modulating electrocautery-induced secondary brain injury, Clinical neuroscience. 2013, 20(9): 1329-1330. |
| Yuan Q., Su H., Chiu K., Wu W. and Lin Z.X., Assessment of the rate of spinal motor axonal regeneration by ChAT immunohistochemistry, Journal of Neurosurgery. 2013. |
| Researcher : XU W |
| List of Research Outputs |
| Cheung A., Xu W., Li B., Tsao G.S.W. and Chan K.W., Id1 induced IGF2 promotes bidirectional interaction between oesophageal cancer cells and fibroblasts in the tumour microenvironment, European Cancer Congress, Amsterdam, 27 September - 1 October 2013, Holland. 2013, 392. |
| XU W., Li B., Tsao G.S.W., Chan K.W. and Cheung A., Mechanistic study of the interactions between Id1-overexpressing esophageal cancer cells and fibroblasts in the tumor microenvironment, 2013 NCRI Cancer Conference, 3-6 November 2013, Liverpool, U. K.. 2013, A191. |
| XU W., Li B., Tsao G.S.W., Chan K.W. and Cheung A., Suppression of angiogenesis and esophageal cancer progression by selective targeting of hematopoietic and endothelial progenitor cells, 18th International Vascular Biology Meeting, April 14-17, 2014, Kyoto, Japan. 2014, P-513. |
| Researcher : Xiao J |
| List of Research Outputs |
| PENG B., Xiao J., WANG K., So K.F., Tipoe G.L. and Lin B., Suppression of Microglial Activation Is Neuroprotective in a Mouse Model of Human Retinitis Pigmentosa. The Journal of Neuroscience, 2014, 34: 8139-8150. |
| Xiao J., Ho M.C.T., Liong E.C., Nanji A.A., Leung T.M., Lau T.Y.H., Fung M.L. and Tipoe G.L., Epigallocatechin gallate attenuates fibrosis, oxidative stress, and inflammation in non-alcoholic fatty liver disease rat model through TGF/SMAD, PI3 K/Akt/FoxO1, and NF-kappa B pathways, European Journal of Nutrition. 2014, 53(1): 187-199. |
| Xiao J., Zhu Y.I.N.G.H.U.I., Liu Y.I.N.G.X.I.A., Tipoe G.L., Xing F.E.I.Y.U.E. and So K.F., Lycium Barbarum Polysaccharide Attenuates Alcoholic Cellular Injury Through TXNIP=NLRP3 Inflammasome Pathway. International Journal of Biological Macromolecules, 2014, 69: 73-78. |
| Xiao J., Liong E.C., Chang R.C.C., Fung M.L., Xu A.M., So K.F. and Tipoe G.L., Lycium barbarum polysaccharides protect rat liver from non-alcoholic steatohepatitis-induced injury, Nutrition and Diabetes, Doi:10.1038/nutd.2013.22. 2013, 3,e81. |
| Xiao J., Wang J., Xing F., Han T., Jiao R., Liong E.C., Fung M.L., So K.F. and Tipoe G.L., Zeaxanthin dipalmitate therapeutically improves hepatic functions in an alcoholic fatty liver disease model through modulating MAPK pathway, PLOS ONE. 2014, 9(4): e95214. |
| Xiao J., Zhu Y., Liu Y., Tipoe G.L., Xing F. and So K.F., Lycium barbarum polysaccharide attenuates alcoholic cellular injury through TXNIP-NLRP3 inflammasome pathway, International Journal of Biological Macromolecules. 2014, 69: 73-78. |
| Researcher : Xu W |
| List of Research Outputs |
| Cheung A., Xu W., Li B., Tsao G.S.W. and Chan K.W., Id1 induced IGF2 promotes bidirectional interaction between oesophageal cancer cells and fibroblasts in the tumour microenvironment, European Cancer Congress, Amsterdam, 27 September - 1 October 2013, Holland. 2013, 392. |
| XU W., Li B., Tsao G.S.W., Chan K.W. and Cheung A., Mechanistic study of the interactions between Id1-overexpressing esophageal cancer cells and fibroblasts in the tumor microenvironment, 2013 NCRI Cancer Conference, 3-6 November 2013, Liverpool, U. K.. 2013, A191. |
| XU W., Li B., Tsao G.S.W., Chan K.W. and Cheung A., Suppression of angiogenesis and esophageal cancer progression by selective targeting of hematopoietic and endothelial progenitor cells, 18th International Vascular Biology Meeting, April 14-17, 2014, Kyoto, Japan. 2014, P-513. |
| Researcher : YANG J |
| List of Research Outputs |
| Chan L.K. and Yang J., Faculty development for teaching in the laboratory environment, Physiology Symposium 2014 and Joint Scientific Conference of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong, 12-14 June 2014, Hong Kong.. 2014. |
| LIU J., Li B., Yang J., Huen M.S.Y., Tsao G.S.W. and Cheung A., FBX031 negatively regulates p38 MAPK by promoting ubiquitination and degradation of MAP kinase kinase 6, 20th Hong Kong International Cancer Congress, November 14-15, 2013, Hong Kong. 2013, No. A16. |
| Liu J., HAN L., Li B., Yang J., Huen M.S.Y., Pan X., Tsao G.S.W. and Cheung A., F-box only protein 31 (FBX031) negatively regulates p38 mitogen-activated protein kinase (MAPK) signaling by mediating lysine 48-linked ubiquitination and degradation of mitogen-activated protein kinase kinase 6 (MKK6), Journal of Biological Chemistrry. 2014, 289: 21508-21518. |
| YANG J., Epstein-Barr virus (EBV) BZLFD1 portein interferes with cellular response to DNA damage. 2013, 179 pages. |
| Researcher : YANG X |
| List of Research Outputs |
| SANG Y., Yang X., Ellis-Behnke R.G., So K.F. and Cheung R.T.F., A self-assembling peptide nanofiber scaffold reduces acute brain injury and improves functional recovery in a hypertensive rat model of intracerebral hemorrhage plus clot aspiration, The Conjoint Congress of the 5th World ICH Conference 2013 & 20th Annual Scientific Meeting of Hong Kong Neurosurgical Society. 2013, 106. |
| SANG Y., Yang X., Su H., Leung G.K.K., Wu W. and Cheung R.T.F., Transplantation of NPCs into the hematoma cavity improves functional outcome in a rat model of intracerebral hemorrhage, The Conjoint Congress of the 5th World ICH Conference 2013 & 20th Annual Scientific Meeting of Hong Kong Neurosurgical Society. 2013, 69-70. |
| Sang Y., YANG X., Su H.X., Leung G.K.K., Wu W. and Cheung R.T.F., Local transplantation pf NPC in a rat model of intracerebral hemorrhage plus hematoma evacuation, Cell Symposia: Using Stem Cells to Model and Treat Human Disease, Los Angeles, U.S.A., 21-23 November 2013. |
| Sang Y., YANG X., Su H.X., Leung G.K.K., Wu W. and Cheung R.T.F., Transplantation of neural progenitor cells into the hematoma cavity improves functional outcome in a rat model of intracerebral hemorrhage, The 5th World Conference of Intracerebral Hemorrhage & 20th Annual Scientific Meeting of the Hong Kong Neurosurgical Society, Hong Kong, China, 2-4 November 2013. |
| Su H., Yuan Q., QIN D., Yang X., Wong W.M., So K.F. and Wu W., Lithium enhances axonal regeneration in peripheral nerve by inhibiting glycogen synthase kinase 3b activation, BioMed Research International. 2014, Articile ID 658753: 7 pages. |
| Su H., Yuan Q., QIN D., Yang X., Wong W.M., So K.F. and Wu W., Ventral root re-implantation is better than peripheral nerve transplantation for motoneuron survival and regeneration after spinal root avulsion injury, BMC Surgery. 2013, 13: 21. |
| Researcher : YOU R |
| List of Research Outputs |
| Chang R.C.C., Ho Y.S., WONG T.H.G., TSANG A.W.-.T., WUWONGSE S., POON C.H., YOU R., HUANG C., Ng T.W., CHENG S.Y., Hung C.H.L., LEUNG Y., Yang X., Law A.C.K., Chiu K., Lau W.M., Mak J.C.W., Wong G.T.C., Lee S.M.Y. and Hoi M.P.M., Investigating mechanisms of risk factors for Alzheimer’s disease to learn how to prevent disease progression., International Alzheimer’s Disease Conference 2014. 24. |
| YOU R., Hung C.H.L., CHENG S.Y., Ho Y.S. and Chang R.C.C., Neuroprotective effects of honokiol in 6-hydroxydopamine-induced neurotoxicity., The 9th International Symposium of Healthy Aging. 2014, 61. |
| Researcher : Yang J |
| Project Title: | Investigation of physiology and possible neuroprotective effect of the retinal microglia under normal and glaucoma conditions |
| Investigator(s): | Yang J, So KF, Chang RCC |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 11/2008 |
| List of Research Outputs |
| Chan L.K. and Yang J., Faculty development for teaching in the laboratory environment, Physiology Symposium 2014 and Joint Scientific Conference of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong, 12-14 June 2014, Hong Kong.. 2014. |
| LIU J., Li B., Yang J., Huen M.S.Y., Tsao G.S.W. and Cheung A., FBX031 negatively regulates p38 MAPK by promoting ubiquitination and degradation of MAP kinase kinase 6, 20th Hong Kong International Cancer Congress, November 14-15, 2013, Hong Kong. 2013, No. A16. |
| Liu J., HAN L., Li B., Yang J., Huen M.S.Y., Pan X., Tsao G.S.W. and Cheung A., F-box only protein 31 (FBX031) negatively regulates p38 mitogen-activated protein kinase (MAPK) signaling by mediating lysine 48-linked ubiquitination and degradation of mitogen-activated protein kinase kinase 6 (MKK6), Journal of Biological Chemistrry. 2014, 289: 21508-21518. |
| YANG J., Epstein-Barr virus (EBV) BZLFD1 portein interferes with cellular response to DNA damage. 2013, 179 pages. |
| Researcher : Yang J |
| List of Research Outputs |
| Chan L.K. and Yang J., Faculty development for teaching in the laboratory environment, Physiology Symposium 2014 and Joint Scientific Conference of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong, 12-14 June 2014, Hong Kong.. 2014. |
| LIU J., Li B., Yang J., Huen M.S.Y., Tsao G.S.W. and Cheung A., FBX031 negatively regulates p38 MAPK by promoting ubiquitination and degradation of MAP kinase kinase 6, 20th Hong Kong International Cancer Congress, November 14-15, 2013, Hong Kong. 2013, No. A16. |
| Liu J., HAN L., Li B., Yang J., Huen M.S.Y., Pan X., Tsao G.S.W. and Cheung A., F-box only protein 31 (FBX031) negatively regulates p38 mitogen-activated protein kinase (MAPK) signaling by mediating lysine 48-linked ubiquitination and degradation of mitogen-activated protein kinase kinase 6 (MKK6), Journal of Biological Chemistrry. 2014, 289: 21508-21518. |
| YANG J., Epstein-Barr virus (EBV) BZLFD1 portein interferes with cellular response to DNA damage. 2013, 179 pages. |
| Researcher : Yang X |
| List of Research Outputs |
| SANG Y., Yang X., Ellis-Behnke R.G., So K.F. and Cheung R.T.F., A self-assembling peptide nanofiber scaffold reduces acute brain injury and improves functional recovery in a hypertensive rat model of intracerebral hemorrhage plus clot aspiration, The Conjoint Congress of the 5th World ICH Conference 2013 & 20th Annual Scientific Meeting of Hong Kong Neurosurgical Society. 2013, 106. |
| SANG Y., Yang X., Su H., Leung G.K.K., Wu W. and Cheung R.T.F., Transplantation of NPCs into the hematoma cavity improves functional outcome in a rat model of intracerebral hemorrhage, The Conjoint Congress of the 5th World ICH Conference 2013 & 20th Annual Scientific Meeting of Hong Kong Neurosurgical Society. 2013, 69-70. |
| Sang Y., YANG X., Su H.X., Leung G.K.K., Wu W. and Cheung R.T.F., Local transplantation pf NPC in a rat model of intracerebral hemorrhage plus hematoma evacuation, Cell Symposia: Using Stem Cells to Model and Treat Human Disease, Los Angeles, U.S.A., 21-23 November 2013. |
| Sang Y., YANG X., Su H.X., Leung G.K.K., Wu W. and Cheung R.T.F., Transplantation of neural progenitor cells into the hematoma cavity improves functional outcome in a rat model of intracerebral hemorrhage, The 5th World Conference of Intracerebral Hemorrhage & 20th Annual Scientific Meeting of the Hong Kong Neurosurgical Society, Hong Kong, China, 2-4 November 2013. |
| Su H., Yuan Q., QIN D., Yang X., Wong W.M., So K.F. and Wu W., Lithium enhances axonal regeneration in peripheral nerve by inhibiting glycogen synthase kinase 3b activation, BioMed Research International. 2014, Articile ID 658753: 7 pages. |
| Su H., Yuan Q., QIN D., Yang X., Wong W.M., So K.F. and Wu W., Ventral root re-implantation is better than peripheral nerve transplantation for motoneuron survival and regeneration after spinal root avulsion injury, BMC Surgery. 2013, 13: 21. |
| Researcher : Yau SY |
| List of Research Outputs |
| Yau S.Y. and So K.F., Adult neurogenesis and dendritic remodeling in hippocampal plasticity; Which one is more important?, Cell Transplantation. 2014, 23: 471-479. |
| Yau S.Y., LI A., Zhang E., Christie B.R., Xu A., Lee T.M.C. and So K.F., Sustained Running in Rats Adminstered Corticosterone Prevents the Development of Depressive Behaviors and Enhances Hoppocampal Neurogenesis and Synaptic Plasticity Without Increasing Neurotrophic Factor Levels. Cell Transplantation, 2014, 23: 481-492. |
| Yau S.Y., Li A., Zhang E., Christie B.R., Xu A., Lee T.M.C. and So K.F., Sustained running in rats administered corticosterone prevents the development of depressive behaviors and enhances hippocampal neurogenesis and synaptic plasticity without increasing neurotrophic factor levels, Cell Transplantaton. 2014, 23: 481-492. |
| Researcher : Yeung PKK |
| Project Title: | The Effectiveness of Vasopressin V1 receptor antagonist , SR49059, and V2 Receptor Anatongist, OPC-31260, on Cerebral Edema Formation in Endothelin-1-Overexpressed Mice |
| Investigator(s): | Yeung PKK, Chung SK |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 09/2008 |
| List of Research Outputs |
| Cheng O.Y., Lam K.S.L., Chung S.K., Xu A., Yeung P.K.K., Kwan S.C., Ho W.L., Cheng K.Y., Guo Y. and Chan K.H., Cognitive impairment in adiponectin-knockout mice, 19th Medical Research Conference, Department of Medicine, The University of Hong Kong,. Hong Kong, Hong Kong Medicine Journal, 2014, 20 Number 1 (Suppl 1): 14. |
| Guo Y., Chung S.K., Siu D.C.W., Kwan S.C., Ho W.L., Yeung P.K.K., Teo K.C. and Chan K.H., Endothelin-1 overexpression exacerbate experimental allergic encephalomyelitis, Physiology Symposium 2014 & Joint Scientific Conference of The Hong Kong Society of Neurosciences & The Biophysical Society of Hong Kong. 2014. |
| Researcher : Yip HKF |
| Project Title: | In vivo gene transfer of the catalytic subunit of telomerase protects retinal ganglion cells against axotomy-induced cell death |
| Investigator(s): | Yip HKF, Tsao GSW, Chung SK |
| Department: | Anatomy |
| Source(s) of Funding: | Seed Funding Programme for Basic Research |
| Start Date: | 05/2005 |
| Project Title: | Telomerase immortalization of retinal ganglion cells derived from the embryonic mouse retinal progenitor cells |
| Investigator(s): | Yip HKF, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 01/2009 |
| Project Title: | Combined treatment of lithium and noggin inhibits astroglios after spinal cord injury by deactivation of GSK-3β/STAT3 are BMP/Smad pathways in the endogenous adult neural stem cells |
| Investigator(s): | Yip HKF, Shum DKY |
| Department: | Anatomy |
| Source(s) of Funding: | Spinal Cord Injury Research Grant |
| Start Date: | 05/2010 |
| Project Title: | Lithium has an anti-inflammatory role in recovery from spinal cord injury in mice |
| Investigator(s): | Yip HKF |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2013 |
| Completion Date: | 05/2014 |
| Project Title: | Inhibition of GSK3β promotes generation of functional oligodendrocytes from progenitor cells of adult injured spinal cord |
| Investigator(s): | Yip HKF |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 06/2014 |
| List of Research Outputs |
| DAI Y., PAN Y. and Yip H.K.F., Combined Lithium And Noggin Treatment Regulates The Differentiation Of Neural Progenitor Cells In The Adult Spinal Cord And Promotes Functional Recovery After Chronic Spinal Cord Injury, 18th Research Postgraduate Sympsoium. 2013. |
| DAI Y., PAN Y., Cheung M.P.L. and Yip H.K.F., Inhibition Of Stat/smad Co-transcription Factor P300 Regulates Differentiation Of Adult Spinal Cord Neural Progenitors And Ameliorates Functional Recovery In Chronic Spinal Cord, Ninth International Symposium On Healthy Aging. 2014. |
| PAN Y., DAI Y. and Yip H.K.F., The Role Of GSK3-Beta Pathway In Oligodendroglial Progenitor Cell (OPC) Differentiation And Remyelination After Spinal Cord Injury (SCI), 18th Research Postgraduate Symposium, Li Ka Shing Faculty Of Medicine, HKU. 2013. |
| PAN Y., DAI Y., Cheung M.P.L. and Yip H.K.F., The Role Of GSK3-beta Pathway In Oligodendroglial Progenitor Cell Differentiation And Remyelination After Spinal Cord Injury, Ninth International Symposium On Healthy Aging. 2014. |
| Researcher : Yip YL |
| Project Title: | Establishment and characterization of representative nasopharyngeal carcinoma cell lines |
| Investigator(s): | Yip YL, Tsao GSW |
| Department: | Anatomy |
| Source(s) of Funding: | Small Project Funding |
| Start Date: | 03/2014 |
| List of Research Outputs |
| Tsang C.M., Cheung Y.C., Lui W.Y.V., Yip Y.L., Zhang G., LIN W., Cheung K.C.P., Feng Y. and Tsao G.S.W., Berberine suppresses tumorigenicity and growth of nasopharyngeal carcinoma cells by inhibiting STAT3 activation induced by tumor associated fibroblasts, BMC Cancer. 2013, 13: 619. |
| Tsao G.S.W., Yip Y.L., Tsang C.M., Pang P.S., LAU M.Y., Zhang G. and Lo K.W., Etiological factors of nasopharyngeal carcinoma, Oral Oncology. 2014, 50: 330-8. |
| Yip Y.L., Pang P.S., Deng W., Tsang C.M., Zeng M., Hau P.M., Man C., Jin Y., Yuen A.P. and Tsao G.S.W., Efficient immortalization of primary nasopharyngeal epithelial cells for EBV infection study., PLoS One. 2013, 8: e78395. |
| Researcher : Youdim MBH |
| List of Research Outputs |
| GUO R., Lin B., PAN J., Liong E.C., Fung M.L., So K.F., Youdim M.B.H. and Tipoe G.L., M30 multi-functional drug reduces apoptosis, oxidative stress and inflammation in CCl4 -induced acute liver injury animal model, The Physiology Symposium 2014, P9, 6/2014, 2014. |
| GUO R., Lin B., PAN J., Liong E.C., Fung M.L., So K.F., Youdim M.B.H. and Tipoe G.L., M30 multi-functional drug reduces apoptosis, oxidative stress and inflammation in CCl4-induced acute liver injury animal model, The Ninth International Symposium on Healthy Aging – Aging with Confidence, P64, 3/2014. |
| Researcher : Yuan Q |
| List of Research Outputs |
| Su H., Yuan Q., QIN D., Yang X., Wong W.M., So K.F. and Wu W., Lithium enhances axonal regeneration in peripheral nerve by inhibiting glycogen synthase kinase 3b activation, BioMed Research International. 2014, Articile ID 658753: 7 pages. |
| Researcher : ZHANG Q |
| List of Research Outputs |
| WUWONGSE S., CHENG S.Y., WONG T.H.G., Hung C.H.L., ZHANG Q., HO Y.S., Law A.C.K. and Chang R.C.C., Effects of corticosterone and amyloid-beta on proteins essential for synaptic function: Implications for depression and Alzheimer's disease, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease. 2013. |
| Researcher : Zhang E |
| List of Research Outputs |
| Chang R.C.C., Wuwongse S., Wong S., Wong M.T.H., TSANG A.W.-.T., Zhang E., CHENG S.Y., Hung C.H.L., Lau W.M., Ho Y.S., So K.F. and Law A.C.K., Investigating biological mechanisms of corticosterone-induced neurodegeneration: Implication of how depression promotes cognitive impairment in Alzheimer's disease, Alzheimer's & Dementia: The Journal of the Alzheimer's Association. 2013, 9 Issue 4 Supplement: 561-562. |
| Yau S.Y., LI A., Zhang E., Christie B.R., Xu A., Lee T.M.C. and So K.F., Sustained Running in Rats Adminstered Corticosterone Prevents the Development of Depressive Behaviors and Enhances Hoppocampal Neurogenesis and Synaptic Plasticity Without Increasing Neurotrophic Factor Levels. Cell Transplantation, 2014, 23: 481-492. |
| Yau S.Y., Li A., Zhang E., Christie B.R., Xu A., Lee T.M.C. and So K.F., Sustained running in rats administered corticosterone prevents the development of depressive behaviors and enhances hippocampal neurogenesis and synaptic plasticity without increasing neurotrophic factor levels, Cell Transplantaton. 2014, 23: 481-492. |
| Researcher : Zhang G |
| List of Research Outputs |
| Tsang C.M., Cheung Y.C., Lui W.Y.V., Yip Y.L., Zhang G., LIN W., Cheung K.C.P., Feng Y. and Tsao G.S.W., Berberine suppresses tumorigenicity and growth of nasopharyngeal carcinoma cells by inhibiting STAT3 activation induced by tumor associated fibroblasts, BMC Cancer. 2013, 13: 619. |
| Tsao G.S.W., Yip Y.L., Tsang C.M., Pang P.S., LAU M.Y., Zhang G. and Lo K.W., Etiological factors of nasopharyngeal carcinoma, Oral Oncology. 2014, 50: 330-8. |